gebhart/patrepeval huggingface dataset:
O-115 Developing a computerised search to help UK general practices identify more patients for advance care planning: A feasibility study (2015)

<h3>Background</h3> Many patients with advanced conditions are not identified for advance care planning because they are not seen as having “palliative” care needs. In some countries General Practice information technology systems can improve care by identifying patients with deteriorating health so that they can be considered for an ACP and their care reviewed more systematically and effectively. <h3>Aim</h3> The aim was to develop and test a computerised search of primary care records in routine clinical practice as a tool to improve patient identification for a palliative care approach. <h3>Methods</h3> An iterative process of search design and testing followed by implementation and extended testing of the search output in clinical practice. A three-phase feasibility study: developing a computerised search, determining its ability to identify patients with deteriorating health from any advanced condition, and assessing how primary care clinicians use the results to improve patient care. The setting was twelve primary care teams in two Health Boards in Scotland. <h3>Results</h3> The search identified 0.6% to 1.6% of patients in each practice who were not already on the practice palliative care register. Primary care clinicians judged that 30%–60% of these patients were at risk of dying or deterioration over the next 6–12 months. <h3>Discussion</h3> The most common action taken by GPs was to start an electronic “anticipatory care plan”, a specific Scottish form of advance care planning. <h3>Conclusion</h3> It is possible to significantly improve the identification of patients for ACP and palliative care needs assessment using a computerised search. Time-efficient systems were important as was a generic tool for anticipatory care planning not linked to ‘palliative’ care.
Régression gaussienne à poids logistiques et maximum de vraisemblance pénalisé (2013)

International audience
Stress distribution in bone arising from loading on endosteal dental implants (1973)

Abstract Results of a preliminary study of stress in bone around dental implants are presented. Stress is calculated using the method of finite elements. Two blade type and one pin type implant are subjected to horizontal and to vertical forces of 19 lb. Differences in blade implant design do not alter the stress distribution significantly. The pin implant shows that most of the load is carried near the entrance into the bone, with a rapid fall in stress.
Slow scanning electromagnetic scanner for laser display (2008)

A small sized, low power consuming, shock proven optical scanner with a capacitive comb-type rotational sensor for the application of mobile projection display is designed, fabricated, and characterized. To get a 2-D video image, the present device horizontally scans a vertical line image made through a line-type diffractive spatial optical modulator. To minimize, device size as well as power consumption, the mirror surface is placed on the opposite side of the coil actuator. To prevent thermal deformation of the mirror, the mirror is partially connected to the center point of the coil actuator. To be shock proof, mechanical stoppers are constructed in the device. The scanner is fabricated from two silicon wafers and one glass wafer using bulk micromachining technology. The packaged scanner consists of the scanner chip, a pair of magnets, yoke rim, and base plate. The fabricated package size is 9.2×10×3 mm (0.28 cc) and the mirror size is 3×1.5 mm. The scanner chip receives no damage under the shock test with an impact of 2000 G in 1 ms. In the case of a full optical scan angle of 30 deg at 120-Hz driving frequency, linearity, repeatability, and power consumption are measured at 98%, 0.013 deg, and 60 mW, respectively, which are suitable for mobile display applications.
AGING BEHAVIOR OF ALUMINIUM TREATED BY ATMOSPHERIC PRESSUREPLASMAS (2011)

The aim of current work is to present the results about aging
behavior obtained by atmospheric pressure plasma treated
aluminium surface. Diffuse Coplanar Surface Barrier Discharge
plasma source is used as an atmospheric pressure plasma for
surface treatment. The influence of different aging media (like
ambient air, nitrogen, argon, oxygen, vacuum storage) on the
aging effect will be presented and discussed.
Information systems for the management of clinical, administrative and government data of clinical imaging laboratories (2008)

From its first implementation, the integrated clinical and healthcare information system, developed at the CNR Clinical Physiology Institute, undergoes to updated and upgraded procedures and protocols, by solving problems of: harmonization of instrumentation of different brands; management of multimedial data provided by different medical imaging labs; satisfaction of both clinical and research needs as well as legal and economical requirements; user-friendship of the provided tools. Peculiar attention has been paid to the management of the laboratories devoted to biomedical imaging: medical and healthcare operators have coworked with engineers, to get a system able to guarantee coordinated activity, higher efficiency, simplified procedures, major concentration onto the medical decision-making issues, by supporting conventional techniques as well as new hybrid imaging technologies.
Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering. (1985)

von Willebrand factor (vWF) was analyzed by electron microscopic and quasi-elastic light scattering techniques in order to evaluate the size and shape of this heterogeneous polymeric plasma glycoprotein. Electron micrographs demonstrated that native vWF molecules are flexible, linear polymers, ranging in contour length from 100 to 1300 nm. In their typical configuration, the polymers were coiled upon themselves with maximal diameters ranging from 60 to 200 nm. Individual repeating protomeric subunits were discernible in occasionally noted, uncoiled polymers and measured 100 nm X 1.5-2.0 nm. Quasi-elastic light scattering analysis confirmed that measurements of the size and shape of purified vWF molecules in solution were similar to those obtained with electron microscopic techniques. In addition, the mean Stokes radius and mean radius of gyration assessed by quasielastic light scattering were directly related over a wide range of values, as were the diameter and contour length measured from electron micrographs, suggesting that the overall shape of polymers does not change with increasing size. This study supports the concept that native vWF molecules are flexible, linear polymers. In addition, this study clearly shows that the polymer configuration assessed from electron micrographs is a valid representation of the configuration of the polymer in solution. The data presented also provide the first evidence for a well-defined, repeating protomeric subunit.
Neighbor Approximations for Distributed Optimal Control of Nonlinear Networked Systems (2020)

This paper concerns the distributed solution of optimal control problems for the class of nonlinear neighbor-affine systems, for which the dynamics can be written as sum of terms that depend only on the states and controls of two neighboring agents. The proposed distributed optimization algorithm is based on the introduction of local copies of states and controls that are coupled via additional consistency constraints. Formulating the augmented Lagrangian function for the consistency constraints then allows to solve the problem in a distributed manner using the alternating direction method of multipliers (ADMM). This paper proposes to approximate parts of the neighbors optimization problem using local copies of states and controls. While this increases the complexity of the local problems, an extensive numerical evaluation for several benchmark examples shows that the convergence behaviour of the ADMM algorithm is improved significantly and thus the total computation time and the communication effort are decreased.
Hypercholesterolemia Suppresses Inwardly Rectifying K + Channels in Aortic Endothelium In Vitro and In Vivo (2006)

Inwardly rectifying K+ (Kir) channels are responsible for maintaining endothelial membrane potential and play a key role in endothelium-dependent vasorelaxation. In this study, we show that endothelial Kir channels are suppressed by hypercholesterolemic levels of lipoproteins in vitro and by serum hypercholesterolemia in vivo. Specifically, exposing human aortic endothelial cells to acetylated low-density lipoprotein or very low density lipoprotein resulted in a time- and concentration-dependent decrease in Kir current that correlated with the degree of cholesterol loading. The suppression was fully reversible by cholesterol depletion. Furthermore, a decrease in Kir current resulted in depolarization of endothelial membrane potential. Most important, the flow sensitivity of Kir currents was also impaired by cholesterol loading. Specifically, flow-induced increase in Kir current was suppressed by 70%, and flow-induced hyperpolarization was almost completely abrogated. Furthermore, we show that hypercholesterolemia in vivo also strongly suppresses endothelial Kir currents and causes a shift in endothelial membrane potential, as determined by comparing the currents in aortic endothelial cells freshly isolated from healthy or hypercholesterolemic pigs. Therefore, we suggest that suppression of Kir current is one of the important factors in hypercholesterolemia-induced endothelial dysfunction.
ChemInform Abstract: The Surface Science of Heterogeneous Catalysis (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance analysis and dexterity monitoring of hexapod-based simulator (2018)

Washout filter is in demand to generate the vehicle acceleration and angular velocities with high loyalty to make the best realistic motion. The limitation of the simulator's moving platform is an integral part of every motion simulator. Adaptive and model predictive control washout filters contribute with this limitation online. It is necessary to have a real vision to the workspace limitation which is needed for unpredicted next step of the simulator. In this paper dexterity analysis is addressed as a novel method to monitor the performance accuracy of the simulator. The dexterity of both the classical and optimal washout filters are compared. Finally, it is shown that the dexterity analysis in optimal washout filter is necessary to avoid the workspace limitations.
ChemInform Abstract: Electroorganic Chemistry. Part 148. Cathodic Coupling of Aliphatic Esters. Useful Reaction for the Synthesis of 1,2‐Diketone and Acyloin. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Extrinsic coagulation pathway activation and metalloproteinase-2/TIMPs system are related to oxidative stress and atherosclerosis in hemodialysis patients (2004)

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), together with extrinsic coagulation pathway activation and increased oxidative stress (SOX) have all been implicated as important factors in atherosclerosis and vascular remodelling. The aim of the present study was to investigate whether the MMPs/TIMPs system is associated with activation of the extrinsic coagulation pathway in conditions of increased SOX in hemodialysis (HD) patients. In HD patients, with and without cardiovascular disease (CVD), and in controls, we compared pre-dialysis levels of MMP-2, MMP-9,TIMP-1,TIMP-2; the markers of extrinsic coagulation pathway-tissue factor (TF) and its inhibitor (TFPI), prothrombin fragment F1+2 (F1+2); a marker of SOX-Cu/Zn superoxide dismutase (Cu/Zn SOD) and a surrogate of atherosclerotic disease-intima media thickness (IMT). Hemodialysis patients, particularly those with CVD, showed a significant increase in values of MMP-2/TIMPs, markers of the extrinsic coagulation pathway, Cu/Zn SOD and IMT as compared to controls. The markers of coagulation activation positively correlated with the MMP-2/TIMPs system, whereas they did not correlate with MMP-9. In addition, both MMP-2/TIMPs as well as extrinsic coagulation parameters were related to the prevalence of increased SOX, IMT and CVD. Multiple stepwise regression analysis showed that low TIMP-2 followed by increased Cu/Zn SOD and MMP-2 levels independently and significantly predicted elevated IMT on maintenance HD patients. In conclusion, our data suggest that the MMP-2/TIMPs system and an activated extrinsic coagulation pathway could cooperate in conditions of elevated SOX and could influence arterial remodeling resulting in the presence of CVD in haemodialysis patients.
Perioperative Management of Severe Anorexia Nervosa (2014)

Hirose, K.*‡; Hirose, M.§; Tanaka, K.†; Kawahito, S.†; Tamaki, T.*; Oshita, S.† Author Information
Cooperative Q-learning for multiple secondary users in dynamic spectrum access (2011)

In this paper, we present and evaluate learning schemes that allow multiple secondary users to locate and use spectrum opportunities effectively, thus improving efficiency of dynamic spectrum access (DSA) systems. Using simulations, we show that the proposed schemes achieve good performances in terms of throughput and fairness, and does so by interacting with and learning from the environment only, without requiring prediction models of the environment's dynamics and behaviors.
Characterization of Equine Adipose Tissue‐Derived Stromal Cells: Adipogenic and Osteogenic Capacity and Comparison with Bone Marrow‐Derived Mesenchymal Stromal Cells (2007)

Adipose tissue is a potential source of adult stem cells for tissue engineering applications in equine veterinary medicine.
Encyclopedic tumor analysis for guiding treatment of advanced, broadly refractory cancers: results from the RESILIENT trial (2019)

RESILIENT (CTRI/2018/02/011808) was a single arm, open label, phase II/III study to test if label agnostic therapy regimens guided by Encyclopedic Tumor Analysis (ETA) can offer meaningful clinical benefit for patients with relapsed refractory metastatic (r/r-m) malignancies. Patients with advanced refractory solid organ malignancies where disease had progressed following ≥2 lines of systemic treatments were enrolled in the trial. Patients received personalized treatment recommendations based on integrational comprehensive analysis of freshly biopsied tumor tissue and blood. The primary end points were Objective Response Rate (ORR), Progression Free Survival (PFS) and Quality of Life (QoL). Objective Response (Complete Response + Partial Response) was observed in 54 of 126 patients evaluable per protocol (ORR = 42.9%; 95% CI: 34.3%-51.4%, <i>p</i> < 0.0001). At study completion, Disease Control (Complete Response + Partial Response + Stable Disease) was observed in 114 out of 126 patients evaluable per protocol (CBR = 90.5%; 95% CI: 83.9% - 95.0%, <i>p</i> < 0.00001) and Disease Progression in 12 patients. Median duration of follow-up was 138 days (range 31 to 379). Median PFS at study termination was 134 days (range 31 to 379). PFS rate at 90 days and 180 days were 93.9% and 82.5% respectively. The study demonstrated that tumors have latent vulnerabilities that can be identified via integrational multi-analyte investigations such as ETA. This approach identified viable treatment options that could yield meaningful clinical benefit in this cohort of patients with advanced refractory cancers.
RNA polymerase molecules initiating transcription at tandem promoters can collide and cause premature transcription termination (1987)

Using purified E. coli RNA polymerase we have studied the transcription in vitro of a series of DNA fragments carrying two tandemly arranged promoters, where the corresponding transcription start points were separated by 263, 138, 83 and 78 base pairs. In the case where the transcription start points are 83 base pairs apart, there is an interaction between RNA polymerase molecules transcribing from the two promoters. This interaction results in premature termination of the upstream transcript at a precise site. We propose that this is the result of RNA polymerase transcribing from the upstream promoter bumping into polymerase at the downstream promoter. The interaction between the two polymerase molecules is crucially dependent on the distance between the two promoters.
Sup Tables from Lymph Node Metastases in Colon Cancer Are Polyclonal (2023)

&lt;p&gt;1. SNP array metrics 2. Mutation counts&lt;/p&gt;
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF RACECADOTRIL BY SOLID DISPERSION METHODS (2012)

The aim of present work was to enhance the solubility and dissolution rate of poorly water soluble drug, racecodotril by solid dispersion methods. In the present work, solid dispersion of racecadotril were prepared with a carriers like poly vinyl pyrrolidone K30 (PVP K30), polyethylene glycol 6000 (PEG6000) and poloxamer 188 by using kneading, melting, solvent evaporation, freeze drying and physical mixing methods in the 1 : 1, 1 : 2, 1 : 3, 1 : 4 ratios of drug and carrier, respectively. The formulations were further characterized for drug content, solubility, drug release studies. The interaction between drug and carrier was evaluated by using Fourier transform-infra red (FTIR) and Differential scanning calorimetry (DSC) studies. Powder X-ray diffraction (PXRD) studies were also carried out to find out the crystallinity of solid dispersion. All the prepared solid dispersions were found to be fine free flowing powders and drug content was uniform in all formulations. Solubility studies were performed using the distilled water and buffer pH 1.2. It was observed that the solid dispersions have highest solubility compared to pure drug and physical mixture in both medium. The dissolution tests were performed using the USP dissolution apparatus type-I (Basket) in acid buffer solution pH 1.2 for 1 hour. The dissolution rates of racecadotril solid dispersions were much higher than the corresponding physical mixture and pure drug. The results of FTIR revealed that there was no existence chemical interaction between the drug and carriers. The PXRD studies showed that the drug was in amorphous state completely entrapped by the carriers.
Ruthenium-Catalyzed Allylic Alkylations of Chelated Enolates Using Vinyl Dioxolanon-2-ones (2014)

4-Vinyl-substituted 1,3-dioxolan-2-ones are found to be good substrates for Ru-catalyzed allylic alkylations of chelated amino acid ester enolates. cis-1,3-Dioxolan-2-ones are more reactive than the corresponding trans-isomers. The attack occurs preferentially with regioretention at the position of the leaving group with perfect chirality transfer. Therefore, this protocol is a good complement to the Pd-catalyzed processes, which give only linear products with this type of substrate.
Integrated multi-operand optical neurons for scalable and hardware-efficient deep learning (2023)

The optical neural network (ONN) is a promising hardware platform for next-generation neuromorphic computing due to its high parallelism, low latency, and low energy consumption. However, previous integrated photonic tensor cores (PTCs) consume numerous single-operand optical modulators for signal and weight encoding, leading to large area costs and high propagation loss to implement large tensor operations. This work proposes a scalable and efficient optical dot-product engine based on customized multi-operand photonic devices, namely multi-operand optical neurons (MOON). We experimentally demonstrate the utility of a MOON using a multi-operand-Mach-Zehnder-interferometer (MOMZI) in image recognition tasks. Specifically, our MOMZI-based ONN achieves a measured accuracy of 85.89% in the street view house number (SVHN) recognition dataset with 4-bit voltage control precision. Furthermore, our performance analysis reveals that a 128x128 MOMZI-based PTCs outperform their counterparts based on single-operand MZIs by one to two order-of-magnitudes in propagation loss, optical delay, and total device footprint, with comparable matrix expressivity.
IMFOMED: a new component in the CADANS computer network (2002)

The aim of this project was the design and development of a nationwide facility to handle and manipulate cardiac images in combination with other relevant patient data for the medical research environment. The infrastructure used is based on CADANS, a nationwide low-speed TCP/IP network operating between the 8 university hospitals in the Netherlands. The DICOM protocol has been chosen to standardize the communication between different locations. Investigations were carried out to evaluate the effects of lossy data-compression techniques on transmission speed and image quality. A prototype viewing station, based on a graphical user interface, was developed featuring several tools to handle and manipulate the images on screen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Polyvinyl alcohol templates for low cost, high resolution, complex printing (2004)

Templates for imprint lithography and MxL (molecular transfer lithography) are generated by adhesion of a spin-cast film of polyvinyl alcohol (PVA) to a carrier comprised of materials selected for conformability or distortion reduction. Template formation using both polymeric carrier materials and rigid materials, including quartz and glass carrier materials, is demonstrated. The absence of a carrier material altogether to form a suspended thin film is shown to be feasible. The rigid template material is formed by bonding the PVA patterned film to a rigid carrier while still connected to the master pattern, and it is demonstrated that separation occurs at the PVA-silicon master pattern interface. Form factors for the templates include a 25mm×25mm patterned film attached to a 65mm×65mm glass substrate, a full 100 mm pattern bonded to a quartz substrate, and a 100 mm mask of Mylar™ bonded with a patterned PVA film for MxL applications. These carrier materials are developed in a form factor compatible with commercial nanoimprint lithography tools, and for standard contact aligners adapted to perform MxL processing.
Toward a Breast Cancer Vaccine:Work in Progress (2003)

In the current issue of ONCOLOGY, Drs. Emens and Jaffee have provided an excellent overview of the basic mechanisms involved in the tumor-specific immune response, as well as a comprehensive update of research on immune-based therapies for breast cancer.
LibGuides: THE 352 - The American Religious Experience: APA & MLA Style / Writing Center Information (2014)

This eGuide provides Library Information Resources to support research for THE 352 - The American Religious Experience.