gebhart/patrepeval huggingface dataset:
Multiobjective Auction-Based Switching-Off Scheme in Heterogeneous Networks: To Bid or Not to Bid? (2016)

The emerging data traffic demand has caused a massive deployment of network infrastructure, including Base Stations (BSs) and Small Cells (SCs), leading to increased energy consumption and expenditures. However, the network underutilization during low traffic periods enables the Mobile Network Operators (MNOs) to save energy by having their traffic served by third party SCs, thus being able to switch off their BSs. In this paper, we propose a novel market approach to foster the opportunistic utilization of the unexploited SCs capacity, where the MNOs, instead of requesting the maximum capacity to meet their highest traffic expectations, offer a set of bids requesting different resources from the third party SCs at lower costs. Motivated by the conflicting financial interests of the MNOs and the third party, the restricted capacity of the SCs that is not adequate to carry the whole traffic in multi-operator scenarios, and the necessity for energy efficient solutions, we introduce a combinatorial auction framework, which includes i) a bidding strategy, ii) a resource allocation scheme, and iii) a pricing rule. We propose a multiobjective framework as an energy and cost efficient solution for the resource allocation problem, and we provide extensive analytical and experimental results to estimate the potential energy and cost savings that can be achieved. In addition, we investigate the conditions under which the MNOs and the third party companies should take part in the proposed auction.
Chemical-enzymatic synthesis of 3'-amino-2',3'-dideoxy-β-D-ribofuranosides of natural heterocyclic bases and their 5'-monophosphates (1993)

Abstract Treatment of O2, 3′-anhydro-5′-O-trityl derivatives of thymidine (1) and 2′-deoxyuridine (2) with lithium azide in dimethylformamide at 150 °C resulted in the formation of the corresponding isomeric 3′-azido-2′, 3′-dideoxy-5′-O-trityl-β-D-ribofuranosyl N1- (the major products) and N3-nucleosides (3/4 and 5/6). 3′-Amino-2′, 3′-dideoxy-β-D-ribofuranosides of thymidine [Thd(3′NH2)], uridine [dUrd(3′NH2)], and cytidine [dCyd(3′NH2)] were synthesized from the corresponding 3′-azido derivatives. The Thd(3′NH2) and dUrd(3′NH2) were used as donors of carbohydrate moiety in the reaction of enzymatic transglycosylation of adenine and guanine to afford dAdo(3′NH2) and dGuo(3′NH2). The substrate activity of dN(3′NH2) vs. nucleoside phosphotransferase of the whole cells of Erwinia herbicola was studied.
Phosphorus oxide gate dielectric for black phosphorus field effect transistors (2018)

The environmental stability of the layered semiconductor black phosphorus (bP) remains a challenge. Passivation of the bP surface with phosphorus oxide, POx, grown by a reactive ion etch with oxygen plasma is known to improve photoluminescence efficiency of exfoliated bP flakes. We apply phosphorus oxide passivation in the fabrication of bP field effect transistors using a gate stack consisting of a POx layer grown by reactive ion etching followed by atomic layer deposition of Al2O3. We observe room temperature top-gate mobilities of 115 cm2 V−1 s−1 in ambient conditions, which we attribute to the low defect density of the bP/POx interface.
Deriving optimal measurements from the no-signalling theorem (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. M. Barnett, E. Andersson, and S. Croke, "Deriving optimal measurements from the no-signalling theorem," in International Conference on Quantum Information, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper IThH1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
High-power 808 nm lasers with a super-large optical cavity (2005)

We present a detailed design and experimental study of diode laser structures emitting at 808 nm based on the combination of a GaAsP quantum well with well-established AlGaAs waveguide structures. By increasing the thickness of the confinement layers of the laser structure, its vertical far field divergence is reduced down to 15° with only a small increase of the threshold current and small loss of efficiency. 200 µm aperture 'broad area' devices achieve at a heat sink temperature of 25 °C a continuous wave (CW) output power of more than 15 W with a wall-plug efficiency of 50% with a vertical far field divergence of 18°. This output power illustrates the excellent high-power performance by using super-large optical-cavity structures with improved beam characteristics in comparison to the conventional broad waveguide lasers.
ChemInform Abstract: Structures of New and Known Cyanoglucosides from a North American Plant, Purshia tridentata DC. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Large-scale bulk motions complicate the Hubble diagram (2006)

We investigate the extent to which correlated distortions of the luminosity distance-redshift relation due to large-scale bulk flows limit the precision with which cosmological parameters can be measured. In particular, peculiar velocities of type 1a supernovae at low redshifts, $z&lt;0.2$, may prevent a sufficient calibration of the Hubble diagram necessary to measure the dark energy equation of state to better than 10%, and diminish the resolution of the equation of state time-derivative projected for planned surveys. We consider similar distortions of the angular-diameter distance, as well as the Hubble constant. We show that the measurement of correlations in the large-scale bulk flow at low redshifts using these distance indicators may be possible with a cumulative signal-to-noise ratio of order 7 in a survey of 300 type 1a supernovae spread over 20 000 square degrees.
Molecular Cloning and Characterization of a Plant Serine Acetyltransferase Playing a Regulatory Role in Cysteine Biosynthesis from Watermelon (1995)

Serine acetyltransferase (SATase; EC 2.3.1.30), which catalyzes the reaction connecting serine and cysteine/methionine metabolism, plays a regulatory role in cysteine biosynthesis in plants. We have isolated a cDNA clone encoding SATase by direct genetic complementation of a Cys- mutation in Escherichia coli using an expression library of Citrullus vulgaris (watermelon) cDNA. The cDNA encodes a polypeptide of 294 amino acids (31,536 Da) exhibiting 51% homology with that of E. coli SATase. DNA-blot analysis indicated the presence of a single copy of the SATase gene (sat) in watermelon. RNA hybridization analysis suggested the relatively ubiquitous and preferential expression in the hypocotyls of etiolated seedlings. Immunoblot analysis indicated the accumulation of SATase predominantly in etiolated plants. L-Cysteine, an end product of the cysteine biosynthetic pathway, inhibited the SATase in an allosteric manner, indicating the regulatory function of SATase in this metabolic pathway, whereas beta-(pyrazole-1-yl)-L-alanine, a secondary metabolite formed partly through the cysteine biosynthetic pathway, showed no inhibitory effect. A multi-enzyme complex was formed from recombinant proteins of SATase and cysteine synthase (O-acetylserine(thiol)-lyase) from watermelon, suggesting efficient metabolic channeling from serine to cysteine, preventing the diffusion of intermediary O-acetyl-L-serine.
Atopic Dermatitis and Respiratory Allergy: What is the Link (2015)

Understanding the aetiology and progression of atopic dermatitis and respiratory allergy may elucidate early preventative and management strategies aimed towards reducing the global burden of asthma and allergic disease. In this article, we review the current opinion concerning the link between atopic dermatitis and the subsequent progression of respiratory allergies during childhood and into early adolescence. Advances in machine learning and statistical methodology have facilitated the discovery of more refined definitions of phenotypes for identifying biomarkers. Understanding the role of atopic dermatitis in the development of respiratory allergy may ultimately allow us to determine more effective treatment strategies, thus reducing the patient and economic burden associated with these conditions.
Supplementary Figures 1 through 9 from Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Supplementary Figure 1. Effect of panel A drugs on TNBC cell growth in 96-well format. Supplementary Figure 2. Effect of panel B drugs alone and in combination with panel A drugs on TNBC cell growth. Supplementary Figure 3. Summary of growth inhibition by pairwise drug combinations. Supplementary Figure 4. Hierarchical clustering of cell lines based on response to drug treatments and based on expression of drug targets. Supplementary Figure 5. Principal component analysis to associate patterns of target expression with patterns of drug response. Supplementary Figure 6. Assessment of superadditivity of drug combinations. Supplementary Figure 7. A: Comparison of crizotinib versus XL-184 dose response curves when combined with ABT-263 in the six TNBC cell lines. Supplementary Figure 8. ABT-263 and crizotinib induce apoptosis in TNBC cells. Supplementary Figure 9. Expression of MET and AXL in a cohort of 59 TNBC samples from the TCGA breast cancer cohort relative to the median expression of each gene in all breast cancer samples in TCGA.&lt;/p&gt;
Portrait of locally driven quantum phase transition cascades in a molecular monolayer (2022)

Strongly interacting electrons in layered materials give rise to a plethora of emergent phenomena, such as unconventional superconductivity. heavy fermions, and spin textures with non-trivial topology. Similar effects can also be observed in bulk materials, but the advantage of two dimensional (2D) systems is the combination of local accessibility by microscopic techniques and tuneability. In stacks of 2D materials, for example, the twist angle can be employed to tune their properties. However, while material choice and twist angle are global parameters, the full complexity and potential of such correlated 2D electronic lattices will only reveal itself when tuning their parameters becomes possible on the level of individual lattice sites. Here, we discover a lattice of strongly correlated electrons in a perfectly ordered 2D supramolecular network by driving this system through a cascade of quantum phase transitions using a movable atomically sharp electrostatic gate. As the gate field is increased, the molecular building blocks change from a Kondo-screened to a paramagnetic phase one-by-one, enabling us to reconstruct their complex interactions in detail. We anticipate that the supramolecular nature of the system will in future allow to engineer quantum correlations in arbitrary patterned structures.
Cross-resistance to elvitegravir and dolutegravir in 502 patients failing on raltegravir: a French national study of raltegravir-experienced HIV-1-infected patients (2015)

This study shows that a high proportion of viruses remain susceptible to dolutegravir in the case of failure on a raltegravir-containing regimen.
Enhancing robustness of digital watermarking against geometric attack based on fractal transform (2002)

This paper presents a digital image watermarking algorithm based on a fractal transform. It embeds the watermark in the spatial domain. The advantage of this algorithm is that it can successfully resist certain geometric attacks such as rotation, translation, flip, stretch, and zoom as well as normal signal processing operations such as JPEG compression. During detection, it does not need the original image to recover the watermark.
Production of Ring-Shaped Particles by Normal and Metaplastic Tissue. I. Human Skin2 (1975)

Maintenance media incubated with biopsy specimens of human skin tissues contained minute (10-12 nm wide), ring-shaped particles (RSP) similar to those described previously in culture media of mammalian cell lines. In addition to the qualitative demonstration of the particles by electron microscopy, a quantitative method was applied to estimate in media the amount of DNA that could be attributed primarily to RSP content. The amounts of DNA, obtained with 146 test specimens, varied with the pathologic condition of the tissue in the following ascending order: normal skin, verruca vulgaris, seborrheic verruca, actinic keratosis, basal cell carcinoma, and squamous cell carcinoma.
Functionality investigation using a discrete event system approach (1994)

This paper presents a methodology for investigating the functionality of objects in manipulatory tasks. Functionality is defined as the applicability of an object for the fulfillment of a particular purpose. The description of an interaction for investigating the functionality of an object is described using a formalism based on Discrete Event System Theory and the Active Perception paradigm. The notion of an overseer for controlling, arbitrating and fusing assertions from multiple observers is presented. To describe the overall task observability we introduce the concept of piecewise observability. The functionality of a tool for piercing is presented and the feasibility of approach is demonstrated in a series of experiments using a roboti system and a compliant force sensor.
Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome (2018)

Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well established that host strain background is just as important for determining productivity. Here we report that in vivo combinatorial genomic rearrangement of Saccharomyces cerevisiae yeast with a synthetic chromosome V can rapidly generate new, improved host strains with genetic backgrounds favourable to diverse heterologous pathways, including those for violacein and penicillin biosynthesis and for xylose utilisation. We show how the modular rearrangement of synthetic chromosomes by SCRaMbLE can be easily determined using long-read nanopore sequencing and we explore experimental conditions that optimise diversification and screening. This synthetic genome approach to metabolic engineering provides productivity improvements in a fast, simple and accessible way, making it a valuable addition to existing strain improvement techniques.
Effects of intracervical injection of hyaluronidase in primigravidae during labour. (1994)

A study was conducted on 75 primigravidae in labour of which 50 were injected with intracervical injection of hyaluronidase and 25 were taken as control. Labour could be accelerated and shortened by an average of 1.95 hours (p < .01) after intracervical injection of hyaluronidase. Its effect was insignificant on the latent phase of labour while it significantly shortened the active phase of labour by 2.09 hours (p < .001). Its effect on maximum rate of cervical dilatation (0.85 cm/hour) was also found to be statistically significant ie, p < .001. Hyaluronidase had no effect on uterine contractions, duration of 2nd and 3rd stages of labour and on involution of the uterus. There was no incidence of cervical tear in any of the cases.
Simultaneous targeting of estrogen receptor and HER2 in breast cancer (2010)

Approximately 50% of HER2-positive breast cancers express estrogen receptor (ER) and these tumors are characterized by short-lived responses to hormonal agents. Preclinical models have shown that dual targeting of ER and HER2 could reverse and delay the development of drug resistance. Two studies (TAnDEM & EGF3008) have recently been published addressing the combined use of an aromatase inhibitor (AI) and an anti-HER2-targeted agent. Both studies showed that the combined approach is associated with improvement in response rate and progression-free survival compared with an AI alone with an acceptable toxicity profile. These results would indeed extend the treatment options for patients with ER/HER2-positive metastatic breast cancer. In this article, we discuss how the improved understanding of the complex cross-talk between ER and HER2 has resulted in better clinical outcomes. We analyze clinical evidence regarding the combined use of AIs and anti-HER2-targeted agents. We also touch on possible mechanisms of resistance and ways to improve research in this field.
LC PLL With 1.2-Octave Locking Range Based on Mutual-Inductance Switching in 45-nm SOI CMOS (2009)

A wideband <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> PLL in 45-nm SOI CMOS technology is presented that has a center frequency of 12.4 GHz and 1.2 octave locking range. The wideband operation is achieved by switching mutual inductances within the inductor coil of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> oscillator. To minimize resistive switching losses, the inductor coil consists of a non-switchable primary coil and two isolated secondary coils with series switches. When the switches are closed, the overall inductance reduces because of the switched mutual inductances. Three inductor bands, each consisting of 16 switched capacitor sub-bands, span a frequency range from 7.3 to 17.5 GHz. The in-band phase noise measured after a 1/4 divider is better than -107 dBc/Hz at 1 MHz offset frequency in the entire locking range. The PLL is fully differential and its core has a power consumption of 25 mW at the highest oscillation frequency.
Thermal management for high-power wavelength conversion (2013)

Thermal management is discussed in single-pass CW SHG in QPM Mg:SLT. Effective heat capacity in four-side heat removal module is quantitatively characterized by Phase-Matched Calorimetry and enhanced by 50% with narrowing device width.
Influence of bismuth incorporation on the valence and conduction band edges of GaAs1−xBix (2008)

We investigate the electronic properties of GaAs1−xBix by photoluminescence at variable temperature (T=10–430K) and high magnetic field (B=0–30T). In GaAs0.981Bi0.019, localized state contribution to PL is dominant up to 150K. At T=180K the diamagnetic shift of the free-exciton states reveals a sizable increase in the carrier effective mass with respect to GaAs. Such an increase cannot be accounted for by an enhanced localized character of the valence band states, solely. Instead, it suggests that also the Bloch states of the conduction band are heavily affected by the presence of bismuth atoms.
The HDAC1 Inhibitor CBUD-1001 Enhances TRAIL-induced Apoptosis in Colorectal Cancer Cells (2021)

A novel HDAC inhibitor CBUD-1001 sensitizes TRAIL-induced apoptosis via up-regulation of DR5, and that CBUD-1001 and TRAIL combination treatment offers an effective strategy to overcome TRAIL resistance in CRC cells.
P4‐381: DISCLOSURE OF AMYLOID STATUS FOR RISK OF ALZHEIMER'S DISEASE TO COGNITIVELY NORMAL PERSONS WITH SUBJECTIVE COGNITIVE DECLINE (2018)

Disclosing amyloid status to cognitively normal persons with subjective cognitive decline may cause a psychological harm, given that they are viewed as at risk for progression to Alzheimer's disease and prone to anxiety and depression. We previously reported that disclosure of amyloid imaging results to the population had a low risk of psychological difficulties at 6 weeks and 6 months after disclosure. The purpose of the present study was to examine the long-term effect of disclosure in a clinical research setting. Before participating, all participants were provided detailed information about the hypothetical effect of amyloid deposition on cognitive decline. We confirmed that they understood the implication of amyloid positivity and negativity. 42 out of 43 cognitively normal outpatients with subjective cognitive decline completed the amyloid positron emission tomography (PET) at Keio University Hospital. They were divided into amyloid-positive (n = 10) and negative (n = 32) groups. Baseline anxiety and depression levels of the two groups were obtained as measured by the State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory-II (BDI-II). The STAI, BDI-II, and Impact of Event Scale-Revised (IES-R) were conducted at 6 weeks, 6 months, and 1 year after disclosure. No participants withdrew from the study after PET imaging. The levels of anxiety and depression at baseline did not differ between amyloid positive and negative groups. There were no significant differences between groups in the STAI, BDI-II, or IES-R at any point. Means for the STAI, BDI-II, and IES-R in the both groups were well below the cut-off scores over time, and did not significantly change from the baseline. Participants who learned their amyloid positive results and were therefore at risk for developing Alzheimer's disease did not have greater anxiety, depression, or test-related distress than those who learned their amyloid negative results. Disclosing amyloid status to asymptomatic Japanese persons with subjective cognitive decline is unlikely to cause psychological distress in the long term.
ChemInform Abstract: A Remarkable Alkane Protonolysis Reaction: Observation of Stoichiometric Hydrogen Formation. (1990)

Abstract Since its discovery in 1967, the formation of carbocations by protonolysis according to R 3 C‐H + H + → R 3 C + + H 2 is well‐known but the mechanism has remained a subject of controversy because a nonstoichiometric amount of H 2 is usually produced.
ChemInform Abstract: Stress and Electrochromism Induced by Li Insertion in Crystalline and Amorphous V2O5 Thin Film Electrodes. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multimodal Explanations: Justifying Decisions and Pointing to the Evidence (2018)

Deep models that are both effective and explainable are desirable in many settings; prior explainable models have been unimodal, offering either image-based visualization of attention weights or text-based generation of post-hoc justifications. We propose a multimodal approach to explanation, and argue that the two modalities provide complementary explanatory strengths. We collect two new datasets to define and evaluate this task, and propose a novel model which can provide joint textual rationale generation and attention visualization. Our datasets define visual and textual justifications of a classification decision for activity recognition tasks (ACT-X) and for visual question answering tasks (VQA-X). We quantitatively show that training with the textual explanations not only yields better textual justification models, but also better localizes the evidence that supports the decision. We also qualitatively show cases where visual explanation is more insightful than textual explanation, and vice versa, supporting our thesis that multimodal explanation models offer significant benefits over unimodal approaches.
Heart Rate Variability Biofeedback, Self-Regulation, and Severe Brain Injury (2015)

This article describes a study using heart rate variability (HRV) biofeedback to treat emotional dysregulation in 13 individuals with severe chronic brain injury. Measures included HRV indices, tests of attention and problem solving, and informant reports of behavioral regulation. Results demonstrated that individuals with severe brain injury were able to learn HRV biofeedback and increase coherence between the parasympathetic and sympathetic nervous systems. Individuals who attained the greatest coherence were rated as being able to best regulate their emotions and behavior.