gebhart/patrepeval huggingface dataset:
Small-Animal 18F-FDG PET for Research on Octopus vulgaris: Applications and Future Directions in Invertebrate Neuroscience and Tissue Regeneration (2018)

This study aimed to develop a method of administering <sup>18</sup>F-FDG to the common octopus in order to perform a PET biodistribution assay characterizing glucose metabolism in organs and regenerating tissues. <b>Methods:</b> Seven animals (two of which had a regenerating arm) were anesthetized with 3.7% MgCl<sub>2</sub> in artificial seawater and then injected with 18-30 MBq of isosmotic <sup>18</sup>F-FDG through either the left branchial heart or the anterior vena cava. After an uptake time of about 50 min, the animals were sacrificed and placed on the bed of a small-animal PET scanner, and 10-min static acquisitions were obtained at 3-4 bed positions to visualize the entire body. To confirm image interpretation, internal organs of interest were collected and counted with a γ-counter. <b>Results:</b> Administration through the anterior vena cava resulted in a good full-body distribution of <sup>18</sup>F-FDG as seen on the PET images. Uptake was high in the mantle mass and relatively lower in the arms. In particular, the brain, optic lobes, and arms were clearly identified and were measured for their uptake (SUV<sub>max</sub>: 6.57 ± 1.86, 7.59 ± 1.66, and 1.12 ± 0.06, respectively). Interestingly, <sup>18</sup>F-FDG uptake was up to 3-fold higher in the highly proliferating areas of regenerating arms. <b>Conclusion:</b> This study represents a stepping-stone to the use of noninvasive functional techniques for addressing questions about invertebrate neuroscience and regenerative medicine.
Air-stable, surface-oxide free Cu nanoparticles for highly conductive Cu ink and their application to printed graphene transistors (2013)

Air-stable, surface-oxide free Cu nanoparticles are, for the first time, synthesized by surrounding completely the Cu surface with oleic acid incorporated as a capping molecule. XPS analysis, in conjunction with TEM analysis, revealed that the oleic acid is chemisorbed to the Cu surface via a chemical interaction wherein a monodentate bond is included, without leaving behind free (non-interacting) oleic acid, thereby providing complete surface protection against oxidation. By eliminating the surface oxide layer that critically degrades the electrical properties, the surface-oxide free Cu nanoparticle ink facilitates the realization of a solution-processed Cu electrode layer with resistivity as low as 4 μΩ cm, comparable to the resistivity of noble metal-based, solution-processed counterparts. In addition, high resolution Cu electrode patterns with 5 μm line-width are directly printed using an electrohydrodynamic inkjet technique, and graphene transistors with the printed Cu electrodes demonstrate potential applications in printed electronics.
ChemInform Abstract: Bakers′ Yeast Mediated Preparation of Esters of (R)‐ and (S)‐Ethyl 2‐ Formyl‐3‐hydroxy‐2‐methylpropionate. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Integrating e-Payment Services with RIA Applications (2010)

Given the expansion of RIA technologies, it is highly important to deliver a set of best practices for developers in order to integrate e-business applications with e-payment systems. In this article we present a solution for the integration of PayPal Express with a RIA application developed on Flex. We focus both on security and functionality issues.
Modeling of a Hybrid Energy System Integrated With an Intermittent Power Grid in Developing Countries (2014)

Electricity in most developing countries is inefficient, erratic and unreliable. Recent research work on grid-connected hybrid system in developing countries have not considered frequent electricity outage hours per month experienced by consumers. Effort is made to address this critical factor and HOMER software was used to model an intermittent power grid integrated with a hybrid energy system. This shortcoming is addressed by assuming generator component in HOMER to run as grid. This is made possible after some modification to fuel content, minimum load capacity ratio and scheduling capacity of the generator. A city in Nigeria was used to demonstrate this approach, but it can be replicated for any location in developing countries where there is frequent electricity outage. Outcome of the model shows that integrating an intermittent power grid with a hybrid energy system offers a competitive cost of energy, reduction in noise pollution and improved use of renewable energy for electricity generation in developing countries.
The biomechanical congruent system of occlusion. (1989)

The comparative analysis of the morphological shape of the occlusal surfaces in the stomatognathic system is only correct if those curves are compared which belong to one and the same movement of the mandibula. Starting with this requirement the method of analysis of the sagittal-vertical-cuts is explained. The thus obtained protrusive occlusal contours prove to have identical shapes. They can mathematically be described by just one constant. The geometry of the protrusive, occlusal surfaces can therefore be understood as congruent system of always identical sagittal curvatures.
Theoretical Study of the Triplet N4 Potential Energy Surface (2000)

The N4 molecule in its triplet state has been studied using the DFT-B3LYP, CASSCF, and CCSD(T) computational methods. The previously reported Cs (3A' ') minimum was not found to be stable using these methods. A D2d (3A1) minimum was found to be the lowest energy triplet with a closed structure. This minimum is 20.2 kcal/mol higher in energy than Td (1A1) N4 at the CCSD(T)/cc-pVTZ//CCSD(T)/DZP level of theory. The barrier to dissociation has been estimated to ca. 7.5 kcal/mol from CAS(8,8)+MR-ACPF and CAS(8,8)+MR-AQCC calculations. CASSCF(12,12) calculations indicate that the open-chain N4 of C2h (3Bu) symmetry is not stable. The open-chain Cs(3A' ') structure has been found to be a true minimum at all investigated levels of theory. It is 13.4 kcal/mol lower in energy than Td (1A1) N4 at the CCSD(T)/cc-pVTZ//CCSD(T)/DZP level.
FGF21 Promotes Endothelial Cell Angiogenesis through a Dynamin-2 and Rab5 Dependent Pathway (2014)

Binding of angiogenic molecules with cognate receptor tyrosine kinases (RTK) is required for angiogenesis however the precise link between RTK binding, endocytosis, and signaling requires further investigation. Here, we use FGFR1 as a model to test the effects of the large GTPase and endocytosis regulatory molecule dynamin-2 on angiogenic signaling in context of distinct FGF ligands. In vitro, overexpression of dominant negative dynamin-2 (DynK44A) attenuates FGFR1 activation of Erk and tubulogenesis by FGF2. Furthermore, we identify FGF21, a non-classical, FGF ligand implicated in diverse human pathologies as an angiogenic molecule acting through FGFR1 and b-Klotho coreceptor. Disruption of FGFR1 activation of ERK by FGF21 is achieved by perturbation of the function of both dynamin-2 and Rab5 GTPase. In vivo, mice harboring endothelial selective overexpression of DynK44A, show impaired angiogenesis in response to FGF21. In conclusion, dynamin dependent endocytosis of FGFR1 is required for in vitro and in vivo angiogenesis in response to FGF2 and the non-classical FGF ligand, FGF21. These studies extend our understanding of the relationships between RTK binding, internalization, endosomal targeting, and angiogenic signaling.
Geoacoustic inversion of modal dispersion on the New England Mud Patch. I: Experimental quantification of information content in higher-order modes (2021)

This paper presents the results from a geoacoustic inversion study performed using a combustive sound source signal recorded on a vertical line array during the 2017 Seabed Characterization Experiment (SBCEX17). A single receiver modal estimation method (source deconvolution and warping) is recursively applied along the array channels to estimate modal time-frequency dispersion, resulting in modal dispersion data for 18 modes between modes 1 and 21. These data are then used as an input for trans-dimensional Bayesian geoacoustic inversion. The paper compares inversion results obtained with subsets of modes (1 to 7 and 1 to 15) to those obtained with the whole set (modes 1 to 21) to explore the data information content associated with high-order modes. The study shows that high-order modes enable the resolution of fine details in the seabed sound-speed profile, such as a small sound speed increase over the first 8 m of the seabed (i.e., within the upper portion of the so-called “mud layer,” an important feature of the experiment area). [Work supported by the Office of Naval Research.]
P3‐540: IMPLICATIONS OF SLEEP DISPARITIES FOR COGNITIVE TEST PERFORMANCE AMONG AFRICAN AMERICAN AND WHITE OLDER ADULTS: PRELIMINARY EVIDENCE FROM TWO WISCONSIN COHORTS (2019)

Growing evidence suggests that sleep disturbance associates with Alzheimer's disease pathology and that sleep may play a role in later-life cognitive health. New research demonstrates widening racial disparities in sleep: African Americans of all ages report getting less nightly sleep than their white counterparts. In older adults, sleep likely links to cognition through multiple pathways shaped by socioenvironmental and physiological contexts. We examined relationships of sleep quantity and quality with cognitive test performance in middle-aged and older, cognitively normal African Americans and non-Hispanic whites. Participants (N=1,579; 7.9% African American) self-reported on sleep and completed comprehensive neuropsychological testing. Key predictors included nightly sleep duration and a duration quadratic to assess non-linearity, perceived adequacy of sleep, and daytime somnolence. Cognitive outcomes included measures of executive function (Trails A and B times, log-transformed) and episodic memory (Rey Auditory Verbal Learning Test, Trials 1–5 & Delayed, summed and log-transformed). We stratified by race before using mixed-effects regression to assess predictor-outcome relationships while controlling for demographics and waist-hip ratio. Daytime somnolence did not differ by race, but African Americans (n=125) reported poorer sleep adequacy and shorter sleep duration per night than non-Hispanic whites (n=1,454; Table 1). Somnolence and sleep adequacy predicted cognitive performance only among whites (Tables 2 and 3), and cognitive associations with sleep duration also varied by race. In African Americans, shorter sleep duration appeared associated with poorer performance on all tests, though precision was limited due to sample size. Directionality was reversed within the white sample: longer sleep predicted poorer executive function. Non-linearity of relationships can be seen in Figure 1.
Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration (2023)

ETS2 repressor factor (<i>ERF</i>) insufficiency causes craniosynostosis (CRS4) in humans and mice. ERF is an ETS domain transcriptional repressor regulated by Erk1/2 phosphorylation via nucleo-cytoplasmic shuttling. Here, we analyze the onset and development of the craniosynostosis phenotype in an Erf-insufficient mouse model and evaluate the potential of the residual Erf activity augmented by pharmacological compounds to ameliorate the disease. Erf insufficiency appears to cause an initially compromised frontal bone formation and subsequent multisuture synostosis, reflecting distinct roles of Erf on the cells that give rise to skull and facial bones. We treated animals with Mek1/2 and nuclear export inhibitors, U0126 and KPT-330, respectively, to increase Erf activity by two independent pathways. We implemented both a low dosage locally over the calvaria and a systemic drug administration scheme to evaluate the possible indirect effects from other systems and minimize toxicity. The treatment of mice with either the inhibitors or the administration scheme alleviated the synostosis phenotype with minimal adverse effects. Our data suggest that the ERF level is an important regulator of cranial bone development and that pharmacological modulation of its activity may represent a valid intervention approach both in CRS4 and in other syndromic forms of craniosynostosis mediated by the FGFR-RAS-ERK-ERF pathway.
A Heterogeneous Fleet of Vehicles for Automated Humanitarian Missions (2014)

An automated emergency response system and an experimental framework for its design and validation are presented here. The system consists of a high-level mission optimization and a fleet of heterogeneous autonomous vehicles. The fleet includes ground vehicles for setting up local stations, fixed-wing aircraft for assessing infrastructure damage and performing surveillance, and rotorcraft for delivering emergency supplies. Internet technology provides a unifying environment for the vehicles, optimization module, operators, and emergency responders with support for computational integration in cyberspace.
A New Putative Caulimoviridae Genus Discovered through Air Metagenomics (2018)

Members of the Caulimoviridae family are important plant pathogens. These circular double-stranded DNA viruses may integrate into the host genome, although this integration is not required for the viral replication cycle. Here, we describe three complete genomes belonging to a new putative Caulimoviridae genus discovered through air metagenomics.
Ordered Transmission for Efficient Wireless Autonomy (2018)

Collaborative autonomous systems may rely on wireless communications in dynamic settings. Fundamental to these systems is collaborative decision making, gathering evidence and efficiently producing a joint decision. In many applications fast decision cycles are required and the speed of decision limits the overall system performance. In this paper we develop and analyze a binary hypothesis testing approach using ordered transmission with K \leq N, where N is the number of sensors and K is the number of transmissions to a fusion center. By ordering the local likelihoods the most informative local statistics are transmitted first. Our analysis, using properties of order statistics, characterizes the test and reveals tradeoffs between K and N. This provides a flexible scheme for quick collaborative decision making, with as few as K=1 transmissions, and enables nontraditional tradeoffs by increasing N while keeping K small. The results can be applied to a variety of distributed decision applications.
Cytokinins regulate vascular morphogenesis in the Arabidopsis thaliana root (2005)

38/2004 Martin Bonke The Roles of WOL and APL in Phloem Development in Arabidopsis thaliana Roots 1/2005 Timo Takala Nisin Immunity and Food-Grade Transformation in Lactic Acid Bacteria 2/2005 Anna von Bonsdorff-Nikander Studies on a Cholesterol-Lowering Microcrystalline Phytosterol Suspension in Oil 3/2005 Nina Katajavuori Vangittu tieto vapaaksi— Asiantuntijuus ja sen kehittyminen farmasiassa 4/2005 Ras Trokovic Fibroblast Growth Factor Receptor 1 Signaling in the Early Development of the MidbrainHindbrain and Pharyngeal Region 5/2005 Nina Trokovic Fibroblast Growth Factor 1 in Craniofacial and Midbrain-Hindbrain Development 6/2005 Sanna Edelman Mucosa-Adherent Lactobacilli: Commensal and Pathogenic Characteristics 7/2005 Leena Karhinen Glycosylation and Sorting Of Secretory Proteins in the Endoplasmic Reticulum of the Yeast Saccharomyces cerevisiae 8/2005 Saurabh Sen Functional Studies on alpha2-Adrenergic Receptor Subtypes 9/2005 Tiina E. Raevaara Functional Significance of Minor MLH1 Germline Alterations Found in Colon Cancer Patients 10/2005 Katja Pihlainen Liquid Chromatography and Atmospheric Pressure Ionisation Mass Spectrometry in Analysing Drug Seizures 11/2005 Pietri Puustinen Posttranslational Modifications of Potato Virus A Movement Related Proteins CP and VPg 12/2005 Irmgard Suominen Paenibacillus and Bacillus Related to Paper and Spruce Tree 13/2005 Heidi Hyytiainen Regulatory Networks Controlling Virulence in the Plant Pathogen Erwinia Carotovora Ssp. Carotovora 14/2005 Sanna Janhunen Different Responses of the Nigrostriatal and Mesolimbic Dopaminergic Pathways to Nicotinic Receptor Agonists 15/2005 Denis Kainov Packaging Motors of Cystoviruses 16/2005 Ivan Pavlov Heparin-Binding Growth-Associated Molecule (HB-GAM) in Activity-Dependent Neuronal Plasticity in Hippocampus 17/2005 Laura Seppa Regulation of Heat Shock Response in Yeast and Mammalian Cells 18/2005 Veli-Pekka Jaakola Functional and Structural Studies on Heptahelical Membrane Proteins 19/2005 Anssi Rantakari Characterisation of the Type Three Secretion System in Erwinia carotovora 20/2005 Sari Airaksinen Role of Excipients in Moisture Sorption and Physical Stability of Solid Pharmaceutical Formulations 21/2005 Tiina Hilden Affinity and Avidity of the LFA-1 Integrin is Regulated by Phosphorylation
Hidden variety of biotin–streptavidin/avidin local interactions revealed by site-selective dynamic force spectroscopy (2010)

By site-selective dynamic force spectroscopy realized with the combination of cross-linkers and anatomic force microscope with a force feedback system, we have revealed, for the first time, that the slight difference between the local structures of amino acid residues at the middle sites, SER45 and THR35 for streptavidin and avidin, respectively, strongly affects the microscopic reaction processes, i.e., the variation governs the type of bond as well as the fine structure of the potential landscape. For streptavidin, a bridged or direct hydrogen bond is induced depending on the molecular structure in the buffer solution. For avidin, in contrast, only a direct hydrogen bond is observed for all the buffer solutions used in the experiment. Since final functions in a system are realized through the assembly of local effects, the obtained results indicate the importance of analyzing the reaction processes with respect to the local structures of molecules, for further development of nanoscale functional devices.
Re: Impact of Urology Resident Involvement on Intraoperative, Long-Term Oncologic and Functional Outcomes of Robotic Assisted Laparoscopic Radical Prostatectomy (2020)

No AccessJournal of UrologyUrological Survey1 Jun 2020Re: Impact of Urology Resident Involvement on Intraoperative, Long-Term Oncologic and Functional Outcomes of Robotic Assisted Laparoscopic Radical Prostatectomy Jeffrey A. CadedduMD Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000990AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Impact of Urology Resident Involvement on Intraoperative, Long-Term Oncologic and Functional Outcomes of Robotic Assisted Laparoscopic Radical Prostatectomy." The Journal of Urology, 203(6), p. 1043 © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue 6June 2020Page: 1043-1043 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffrey A. Cadeddu More articles by this author Expand All Advertisement PDF downloadLoading ...
Post-reconstruction filtering of SPECT images by variable conductance diffusion (2003)

The authors investigate the 3-D post-reconstruction filtering of single-photon emission computed tomographic (SPECT) images with variable conductance diffusion (VCD) filters. The idea behind VCD is to smooth the noisy image without blurring the edges. In order to get a better estimate of the conductance function used in VCD, the gradient estimated from the Gaussian blurred image, instead of the image itself, is used. The authors also propose a new method of spatially varying the parameter k of the conductance function which permits smoothing within the region but not across the edges. Although the new method does not outperform the traditional one, further refinement may prove it to be useful. Experiments show that the VCD filters remove considerable noise from the noisy images and maintain the edge information at the same time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Validation of Skeletal Muscle cis-Regulatory Module Predictions Reveals Nucleotide Composition Bias in Functional Enhancers (2011)

We performed a genome-wide scan for muscle-specific cis-regulatory modules (CRMs) using three computational prediction programs. Based on the predictions, 339 candidate CRMs were tested in cell culture with NIH3T3 fibroblasts and C2C12 myoblasts for capacity to direct selective reporter gene expression to differentiated C2C12 myotubes. A subset of 19 CRMs validated as functional in the assay. The rate of predictive success reveals striking limitations of computational regulatory sequence analysis methods for CRM discovery. Motif-based methods performed no better than predictions based only on sequence conservation. Analysis of the properties of the functional sequences relative to inactive sequences identifies nucleotide sequence composition can be an important characteristic to incorporate in future methods for improved predictive specificity. Muscle-related TFBSs predicted within the functional sequences display greater sequence conservation than non-TFBS flanking regions. Comparison with recent MyoD and histone modification ChIP-Seq data supports the validity of the functional regions.
Development of Work Traceability System Using RFID Technology in Plant Construction Management (2008)

In this study, we evaluate the applicability of RFID tags and developed material management system and the work traceability system in plant construction. The examination results indicate that RFID tags and GPS systems were usable enough. About the work traceability, we solved administrative problems of the digital photographs and suggested a method to prove an original or an imitation of the digital photography. And, it was able to reduce time to search for construction materials by the developed systems and time to make a report using digital photographs.