gebhart/patrepeval huggingface dataset:
Design and prototyping a torus machine with a rotocast core. (2008)

A torus machine is considered to be an advantageous machine configuration that is impossible to produce using traditional laminated core technology. This paper presents a torus machine with the stator winding moulded into a composite core, using the RotoCast technology. The goal of the design and the prototyping is to study the advantages when dealing with a soft magnetic mouldable composite material (SM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> C) while looking for alternative and inexpensive production methods.
오바마 행정부의 과학기술정책 분석과 시사점: 조세금융지원제도 및 기술금융 관련 정책 (2008)

□ 주요내용
 
민주당의 경제정책 기조가 시장실패 영역에 대한 정부의 적극적인 개입에 두고 있어 감세보다는 증세 그리고 정부예산 확대를 통한 적극적 공공투자 확대(뉴딜정책 등)에 있기 때문에 과학기술정책분야에도 유사한 정책기조를 펼칠 것으로 예상된다. 
이에 오바마 정부는 부시의 공화당 정부보다 과학기술투자에 더욱 적극적으로 나설 것이나, 조세금융지원제도 측면에서는 한ㆍ미간의 협력에 크게 영향을 미치지는 않을 것으로 판단되며 이를 통해 정책적 시사점을 제시했다.
 
○ 선제적 공적자금 투입과 적절한 금융 재규제를 통한 안정적 자본시장 환경 창출
○ 벤처창업 등에 대한 자본이득세의 감면 및 면제
○ 신재생에너지, 보건의료 및 바이오, 인터넷 등에 대한 정부투자의 확대
Influence of Apolipoprotein E Polymorphism on Bezafibrate Treatment Response in Dyslipidemic Patient (1997)

To examine the significance of apolipoprotein E (apo E) polymorphism in the hypolipidemic effect of bezafibrate, we evaluated the influence of different apo E phenotypes on serum lipid response to bezafibrate treatment in 58 dyslipidemic patients with WHO phenotypes of IIb, IV, or isolated hypo HDL cholesterolemia. Patients were categorized into one of three groups according to apo E phenotypes of E2 (E2/3, n=5), E3 (E3/3, n=35), and E4 (E3/4 and E4/4, n=18). After 3 months daily administration of 400 mg bezafibrate, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels changed on average in the E3 group [-8.0%; p<0.05 and +1.1%; not significant (ns), respectively], the E2 group (-18.3%; p<0.005 and -26.9%; p<0.05, respectively) and the E4 group (+3.8%; ns and +10.1%; ns, respectively). The changes in TC and LDLC levels in the E4 group was significantly less effective compared with those in the E3 (p<0.05) and E2 groups (p<0.01). Bezafibrate induced a reduction in serum triglyceride (TG) levels in the E3 group (-50.1%; p<0.0001), the E2 group (-46.9%; p<0.05) and the E4 group (-44.8%; p<0.005). An increase in high-density lipoprotein cholesterol (HDLC) levels was also observed in the E3 group (+27.5%; p<0.0001), the E2 group (+35.0%; ns) and the E4 group (+38.8%; p<0.005). However, there was no significant difference in the changes of TG and HDLC levels between the groups. These results suggest an important role of apo E polymorphism in modulating serum lipid response to bezafibrate, and phenotyping of apo E helps predict the therapeutic effect of bezafibrate treatment.
Androgen Receptor (AR) NH2- and COOH-Terminal Interactions Result in the Differential Influences on the AR-Mediated Transactivation and Cell Growth (2004)

Early reports showed that androgen receptor (AR) NH2- and COOH-terminal (N-C) interaction was important for full AR function. However, the influence of these interactions on the AR in vivo effects remains unclear. Here we tested some AR-associated peptides and coregulators to determine their influences on AR N-C interaction, AR transactivation, and AR coregulator function. The results showed that AR coactivators such as ARA70N, gelsolin, ARA54, and SRC-1 can enhance AR transactivation but showed differential influences on the N-C interaction. In contrast, AR corepressors ARA67 and Rad9 can suppress AR transactivation, with ARA67 enhancing and Rad9 suppressing AR N-C interaction. Furthermore, liganded AR C terminus-associated peptides can block AR N-C interaction, but only selective peptides can block AR transactivation and coregulator function. We found all the tested peptides can suppress prostate cancer LNCaP cell growth at different levels in the presence of 5alpha-dihydrotestosterone, but only the tested FXXLF-containing peptides, not FXXMF-containing peptides, can suppress prostate cancer CWR22R cell growth. Together, these results suggest that the effects of AR N-C interactions may not always correlate with similar effects on AR-mediated transactivation and/or AR-mediated cell growth. Therefore, drugs designed by targeting AR N-C interaction as a therapeutic intervention for prostate cancer treatment may face unpredictable in vivo effects.
Wellbore Isolation Intervention Devices Utilizing a Metal-to-Metal Rather than an Elastomeric Sealing Methodology (2007)

Abstract Metal-to-metal sealing technology is a medium-to-high expansion, innovative type of seal that utilizes expanding metal to achieve a fully formed pressure barrier on a tubular wall. The presented material will highlight the evolution of common oil and gas industry wellbore isolation/intervention devices that take advantage of a sealing system with an expandable metal-to-metal approach rather than a more traditional/conventional elastomeric packing element style. The applications for the technology within our industry are wide ranging even reaching through areas such as completions, liner hangers, sand control, and flow control. Initially the development was centered around proving the technology from a predominantly live well intervention philosopy focusing on bridge plugs and straddles. The replacement of an elastomeric sealing element applies in many environments; however, the metal-to-metal seal is designed with an extraordinary seal performance envelope that cannot be achieved by conventional elastomeric seals and is perceived to be particularily desirable within the realms of hostile, high pressure, high temperature and geothermal markets. Many common failures in these type of environments leading to NPT issues will be shown to be mitigated with a technology step change in seal design. The results of the learning curve knowledge gained from both the design and implementation phase of the project will be compiled and introduced. Case histories to highlight the effectiveness and uniqueness of the technology will be disseminated in order to show the differentaiting technology between the use of a metal sealing methodology when compared with that of an elastomeric approach. Evaluation of the metal-to-metal sealing technology will offer a guide in order to help in the construction of a set of criteria to fully interpret the benefits and selection of a metal sealing technology over an elastomeric seal. The contributions to our industry will be shown through the features and benefits of the metal-to-metal sealing technology over an elastomeric sealing system.
Reduction in mdx mouse muscle degeneration by low-intensity endurance exercise: a proteomic analysis in quadriceps muscle of exercised compared with sedentary mdx mice (2015)

In our recent study was shown a significant recovery of damaged skeletal muscle of mice with X-linked muscular dystrophy (mdx) following low-intensity endurance exercise, probably by reducing the degeneration of dystrophic muscle. Consequently, in the present work, we aimed to identify proteins involved in the observed reduction in degenerating fibres. To this end, we used proteomic analysis to evaluate changes in the protein profile of quadriceps dystrophic muscles of exercised compared with sedentary mdx mice. Four protein spots were found to be significantly changed and were identified as three isoforms of carbonic anhydrase 3 (CA3) and superoxide dismutase [Cu-Zn] (SODC). Protein levels of CA3 isoforms were significantly up-regulated in quadriceps of sedentary mdx mice and were completely restored to wild-type (WT) mice values, both sedentary and exercised, in quadriceps of exercised mdx mice. Protein levels of SODC were down-regulated in quadriceps of sedentary mdx mice and were significantly restored to WT mice values, both sedentary and exercised, in quadriceps of exercised mdx mice. Western blot data were in agreement with those obtained using proteomic analysis and revealed the presence of one more CA3 isoform that was significantly changed. Based on data found in the present study, it seems that low-intensity endurance exercise may in part contribute to reduce cell degeneration process in mdx muscles, by counteracting oxidative stress.
Comparison of highly lipophilic crown ether carboxylic acids for transport of alkali metal cations from aqueous solutions into chloroform (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of highly lipophilic crown ether carboxylic acids for transport of alkali metal cations from aqueous solutions into chloroformW. A. Charewicz, Gwi Suk. Heo, and Richard A. BartschCite this: Anal. Chem. 1982, 54, 12, 2094–2097Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://doi.org/10.1021/ac00249a042RIGHTS & PERMISSIONSArticle Views94Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (546 KB) Get e-Alertsclose Get e-Alerts
No-fault assurance: linking fast process CAD and EDA (2002)

A prototype system is proposed for incorporating fast process models with EDA management of layout to identify and help arbitrate locations in a chip that are likely subject to less than ideal process effects. The approach uses pattern matching to find those locations in a layout that have the greatest impact from residual imperfections in manufacturing. For each process under study, the maximal lateral test pattern that maximizes the spillover from the surrounding pattern is first determined. The quantitative impact of the spillover for an actual layout is then assessed through comparing the degree of similarity of the actual pattern in a neighborhood about a critical point to the maximal lateral test pattern and scaling the impact accordingly. This fast-CAD pattern-matching approach is shown to be applicable for analysis of yield reduction due to combined effects of defects and alignment tolerances among mask levels as well as for identifying layout areas affected by reflective notching, CMP dishing and, with less accuracy, heating in laser assisted processing.
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase (2012)

The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac hyperactivation and overexpression are associated with aggressive cancers; thus, interference of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors (GEFs), is a viable strategy for inhibiting Rac activity. We synthesized EHop-016, a novel inhibitor of Rac activity, based on the structure of the established Rac/Rac GEF inhibitor NSC23766. Herein, we demonstrate that EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity. The IC(50) of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than for NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells that demonstrate high active levels of the Rac GEF Vav2, EHop-016 inhibits the association of Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac downstream effects of PAK1 (p21-activated kinase 1) activity and directed migration of metastatic cancer cells. Moreover, at effective concentrations (<5 μM), EHop-016 does not affect the viability of transformed mammary epithelial cells (MCF-10A) and reduces viability of MDA-MB-435 cells by only 20%. Therefore, EHop-016 holds promise as a targeted therapeutic agent for the treatment of metastatic cancers with high Rac activity.
Dramatically enhanced photocatalytic properties of Ag-modified graphene–ZnO quasi-shell–core heterojunction composite material (2013)

Preparation of semiconductor heterojunction composites with special nanostructure is an effective way to enhance the photoelectric conversion efficiency of photocatalysts. In this work, the graphene–ZnO composite with quasi-shell–core structure was successfully prepared using a one-step wet chemical method. Silver nanoparticles are loaded onto the graphene–ZnO quasi-shell–core composite by photo-assisted reduction. Ag modification significantly improved the photocatalytic rhodamine B degradation capability of the graphene–ZnO quasi-shell–core composite and all of the rhodamine B dye was degraded by it only after 10 min of white light illumination. The graphene–ZnO composite with quasi-shell–core structure could effectively improve the separation efficiency of the electrons and holes photoinduced by the ZnO. Ag modification could accelerate the reduction processes of the photogenerated electrons and avoid the accumulation of electrons on graphene, resulting in the promotion of the photocatalytic performance of this composite.
An asymmetrical half bridge flyback converter with zero-voltage and zero-current switebing (2005)

In this paper, the analysis and design of an asymmetrical half bridge flyback DC-DC converter is presented, which can minimize the switching power loss by realizing the zero-voltage switching (ZVS) during the transition between the two switches and the zero-current-switching (ZCS) on the output diode. As a result, high efficiency can be achieved. The principle of the converter operation is explained and analyzed. In order to ensure the realization of ZVS in operation, the required interlock delay time between the gate signals of the two switches, the transformer leakage inductance, and the ZVS range of the output current variation are properly calculated. Experimental results from a 8 V/8 A, 200 kHz circuit are also presented, which verify the theoretical analysis.
Non-Invasive Optical Methods for the Study of Cerebral Metabolism in the Human Newborn: A Technique for the Future? (1985)

Two of the major causes of death and disability in the preterm newborn of the developed nations are cerebral ischaemia and intraventricular haemorrhage. It is estimated that intraventricular haemorrhage develops in 40-50% of infants with a birthweight of 1500 g or less but precisely how many individuals are affected by haemorrhage, or how many cases of disability are antedated by cerebral ischaemia, is not known because of the lack of effective low-cost instruments for the continuous, or at least frequent, assessment of cerebral metabolic status in the high-risk individual. In the future, however, fibre-optic-based spectrophotometric techniques for the measurement of cerebral redox state may provide low-cost, portable instruments for the noninvasive assessment of cerebral metabolism during the intensive care of the neonate.
Absence of high red blood cell velocity in the sublingual microcirculation of patients with hyerdynamic septic shock (2015)

A quantitative assessment of the microcirculation in patients with septic shock previously found that microvascular flow and red blood cell (RBC) velocity were decreased1. This study, however, mainly included patients with normodynamic septic shock.
Relaxation of Exciton Confinement in CdSe Quantum Dots by Modification with a Conjugated Dithiocarbamate Ligand (2010)

Coordination of phenyldithiocarbamate (PTC) ligands to solution-phase colloidal CdSe quantum dots (QDs) decreases the optical band gap, E(g), of the QDs by up to 220 meV. These values of DeltaE(g) are the largest shifts achieved by chemical modification of the surfaces of solution-phase CdSe QDs and are-by more than an order of magnitude in energy-the largest bathochromic shifts achieved for QDs in either the solution or solid phases. Measured values of DeltaE(g) upon coordination to PTC correspond to an apparent increase in the excitonic radius of 0.26 +/- 0.03 nm; this excitonic delocalization is independent of the size of the QD for radii, R = 1.1-1.9 nm. Density functional theory calculations indicate that the highest occupied molecular orbital of PTC is near resonant with that of the QD, and that the two have correct symmetry to exchange electron density (PTC is a pi-donor, and the photoexcited QD is a pi-acceptor). We therefore propose that the relaxation of exciton confinement occurs through delocalization of the photoexcited hole of the QD into the ligand shell.
Terrestrial animal tracking as an eye on life and planet (2015)

Moving animals connect our world, spreading pollen, seeds, nutrients, and parasites as they go about the their daily lives. Recent integration of high-resolution Global Positioning System and other sensors into miniaturized tracking tags has dramatically improved our ability to describe animal movement. This has created opportunities and challenges that parallel big data transformations in other fields and has rapidly advanced animal ecology and physiology. New analytical approaches, combined with remotely sensed or modeled environmental information, have opened up a host of new questions on the causes of movement and its consequences for individuals, populations, and ecosystems. Simultaneous tracking of multiple animals is leading to new insights on species interactions and, scaled up, may enable distributed monitoring of both animals and our changing environment.
Direct hydrogenation of CO2 on deposited iron-containing catalysts under supercritical conditions (2018)

The hydrogenation of CO2 in the supercritical state on supported Fe/TiO2 catalysts (0.5–1% iron) at 350–550 °C affords carbon monoxide and methane, the conversion of CO2 approaching 24%. The work demonstrates the possibility of significant increase in the productivity of CO2 hydrogenation process and prolongation of the working time of the catalyst.
Suitability of CPC-18 and Carbonation of Specialty Cementitious Systems (2022)

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Biosensors Based on Electropolymerized Films (2010)

This chapter contains sections titled: Introduction Chronological Evolution of the Concept of Biosensors Based on Electropolymerized Films: Principal Stages Formation of Polymer Films by Direct Electropolymerization of the Biomolecule Adsorption on Electrogenerated Polymers Mechanical Entrapment within Electropolymerized Films Covalent Binding at the Surface of Electropolymerized Films Noncovalent Binding by Affinity Interactions with the Electropolymerized Films Outlook References
Qualitative Analysis of Integration Adapter Modeling (2015)

Integration Adapters are a fundamental part of an integration system, since they provide (business) applications access to its messaging channel. However, their modeling and configuration remain under-represented. In previous work, the integration control and data flow syntax and semantics have been expressed in the Business Process Model and Notation (BPMN) as a semantic model for message-based integration, while adapter and the related quality of service modeling were left for further studies. In this work we specify common adapter capabilities and derive general modeling patterns, for which we define a compliant representation in BPMN. The patterns extend previous work by the adapter flow, evaluated syntactically and semantically for common adapter characteristics.
Comparisons of Two Types of Particle Tracking Models Including the Effects of Vertical Velocity Shear (2020)

In this study, two types of particle tracking models were presented to investigate the applicability in the two-dimensional solute mixing simulations. The conventional particle tracking model, denoted as PTM, was developed based on Fick’s law, which adopted the dispersion coefficient to calculate the random displacements. The other model is the particle dispersion model (PDM), which computes the shear dispersion process by dividing into two computation procedures as the shear translation and the vertical mixing. The PTM and the PDM included the effects of vertical profiles of velocity in the computation of dispersion coefficients and the shear translation step, respectively. The main difference between the two models is whether the shear dispersion process is reproduced using Fick’s law or the direct computation method. These differences were clearly revealed by comparing with the analytic solution of the advection-dispersion equation. The concentration curve resulting from the PTM shows the Gaussian curves, which were well-fitted with the analytic solution in both initial and Taylor periods. Meanwhile, the PDM presented skewed curves in the initial period and gradually turned to the symmetric shape in the Taylor period. The inherent differences of the two particle tracking models were scrutinized against the two-dimensional tracer test results, which show the non-Fickian mixing properties. The comparisons of concentration–time curves reveal that the PDM reproduced a more accurate shape of the curves than the results by the PTM by demonstrating skewed concentration curves.
Ordered Arrays of Nanostructures and Applications in High‐Efficient Nano‐Generators (2007)

Abstract Large‐scale ordered nanostructure arrays on substrates, including nanowires, nanotubes, nanodots, and nano‐holes, can be fabricated using template fabrication processes. The controllable structural parameters and properties of the ordered nanostructure arrays make them quite suitable to be used in many device‐related application areas. It is shown that large‐scale nanowire arrays are good candidates for the realization of a nano‐generator based on the piezoelectric effect of ZnO nanowires. The mechanism of a proposed high‐efficient nano‐generator based on an assembled nanowire/nanohole embedded structure shows high application potentials for biological and nanometer‐sized devices.