gebhart/patrepeval huggingface dataset:
High-order harmonic spectroscopy in an ionized high-density target (2022)

We use high-order harmonic spectroscopy to study ionization dynamics in a macroscopic target with tunable density, spanning over six orders of magnitude. In an in situ pump-probe experiment, the target is prepared at different densities with varying degrees of laser-induced ionization. High-order harmonic radiation is generated in the pre-ionized target, and a steepening in the decrease of the harmonic yield is observed for increasing pre-ionization, allowing not only to identify the contributing quantum paths during high-order harmonic generation but also in determining the amount of ionization within the target. The measurements allow probing of ionization dynamics in laser-induced plasma with high spatio-temporal resolution and are specifically of interest for the optimization of the harmonic generation process in high-density targets with number densities of up to 10 22 cm −3 .
Design and Evaluation of the Optimal Cache Allocation for Content-Centric Networking (2015)

Content-centric networking (CCN) is a promising framework to rebuild the Internet's forwarding substrate around the concept of content. CCN advocates ubiquitous in-network caching to enhance content delivery, and thus each router has storage space to cache frequently requested content. In this work, we focus on the cache allocation problem, namely, how to distribute the cache capacity across routers under a constrained total storage budget for the network. We first formulate this problem as a content placement problem and obtain the optimal solution by a two-step method. We then propose a suboptimal heuristic method based on node centrality, which is more practical in dynamic networks with frequent content publishing. We investigate through simulations the factors that affect the optimal cache allocation, and perhaps more importantly we use a real-life Internet topology and video access logs from a large scale Internet video provider to evaluate the performance of various cache allocation methods. We observe that network topology and content popularity are two important factors that affect where exactly should cache capacity be placed. Further, the heuristic method comes with only a very limited performance penalty compared to the optimal allocation. Finally, using our findings, we provide recommendations for network operators on the best deployment of CCN caches capacity over routers.
Tunable barium strontium titanate thin film capacitors for RF and microwave applications (2002)

The measurement results for thin film barium strontium titanate (BST) based voltage tunable capacitors intended for RF applications are reported. At 9 V DC, BST capacitors fabricated using MOCVD (metalorganic chemical vapor deposition) method achieved 71% (3.4:1) tunability. The measured device quality factor (Q) for BST varactors is comparable with the device Q for commercially available varactor diodes of similar capacitance. The typical dielectric loss tangent was in the range 0.003-0.009 at VHF. Large signal measurement and modeling results for BST thin film capacitors are also presented.
ChemInform Abstract: Convenient Synthesis, Separation, and X‐Ray Crystal Structure Determinations of 1(e),3(e),5(e)‐Trimethylcycloborazane and 1(e),3(e),5(a)‐Trimethylcycloborazane. (1987)

Abstract The cycloborazane (II) is prepared as a mixture of the title isomers (IIA) and (IIB) on reaction of a commercial solution of the complex (I) with equimolar amounts of methylamine followed by reflux of a monoglyme solution of the amine‐borane complex thus obtained.
Ultrasonic Cardiac Output Monitoring and Microcirculation: Is It Worthwhile to Consider in Reconstructive Microsurgery? (2008)

We read with great interest the report by Dr. Setälä and coworkers focusing the metabolic response in microvascular flaps during partial pedicle obstruction and hypovolemic shock.[1] We believe that this article has touched an important issue of reconstructive microsurgery. That is, how does macrocirculation affect microcirculation in a reconstructive microsurgical environment?
Development of high-operating-temperature infrared detectors with gold-doped Hg0.70Cd0.30Te (2004)

Excellent high-operating-temperature infrared photodiodes in the medium-wavelength infrared spectral band with cutoff wavelengths ∼5 μm at 77 K were fabricated on Hg1−xCdxTe samples (x∼0.30) prepared by liquid-phase epitaxy in a tellurium-melt reactor. The samples were doped with indium to ∼1×1014 cm−3 and gold to ∼5×1015 cm−3. Thick planar diodes (∼80 μm thick) and thin cylindrical diodes (∼10 μm thick) of the n-on-p type were fabricated, and they gave comparable, excellent detector dark values within a factor of two. At 130 K, dark currents as low as 5×10−7 A/cm2 were obtained.
Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee (1990)

1. In the spinalized cat, nociceptive spinal neurons with knee input show enhanced responses to mechanical stimulation of that joint once an inflammation has developed in the knee. Enhanced responses may result from increased afferent inflow as well as from modifications of the nociceptive processing within the spinal cord. To examine the significance of these components, we tested in 30 chloralose-anesthetized, spinalized cats whether, during development of arthritis, changes of responsiveness in spinal neurons are restricted to stimulation of the inflamed joint or whether responsiveness in these neurons is altered in general. While continuously recording from a neuron, we injected kaolin and carrageenan into one knee and tested the responses to mechanical stimuli applied to the joint and to regions adjacent to and remote from the knee during the developing arthritis. In addition, in six cats we monitored the neurons' responses to electrical stimulation of the sural nerves and the rostral lumbar spinal cord. 2. Of 32 neurons in laminae VI, VII, and VIII of the lumbar spinal cord, 15 ascending and eight nonascending cells were driven by mechanical stimulation of one or both knee joint(s). Nine of these were nociceptive specific (NS), responding exclusively or predominantly to noxious compression of the knee and other deep tissue, and 12 were wide-dynamic-range (WDR) cells with graded responses to gentle and noxious stimuli applied to the knee joint(s), deep tissue, and skin. Two neurons with high ongoing discharges had some excitatory joint input but showed marked inhibition by most stimuli used (INH neurons). The majority of the neurons had receptive fields on both legs. Nine of the 32 neurons had no input from the knee(s). 3. All 23 neurons with joint input became sensitive or more responsive to movements and gentle compression of the inflamed knee once the inflammation had developed. In general, these neurons also showed enhanced responses to compression of the adjacent muscles in thigh and lower leg. In 20 neurons, response properties were even altered for stimuli applied to regions remote from the inflamed joint, including the contralateral leg in 18 cases. We found expansion of initially restricted receptive fields (mainly in NS cells), enhancement of preexisting responses, and/or lowering of threshold to mechanical stimuli applied to these regions; few neurons developed inhibitory reactions.(ABSTRACT TRUNCATED AT 400 WORDS)
Zeolite Membrane for Dehydration of Isopropylalcohol–Water Mixture by Vapor Permeation (2015)

Highly stable FAU-type zeolite membrane for the separation of isopropanol (IPA)-water mixture by pervaporation is described. FAU membrane showed high water permselectivity and permeance. Comparison of FAU membrane with a conventional LTA-type zeolite membrane revealed superior stability of FAU zeolite membrane in a mixture containing a large water content.
Weak Halogen Bonding in Solid Haloanilinium Halides Probed Directly via Chlorine-35, Bromine-81, and Iodine-127 NMR Spectroscopy (2012)

A series of monohaloanilinium halides exhibiting weak halogen bonding (XB) has been prepared and characterized by 35Cl, 81Br, and 127I solid-state nuclear magnetic resonance (SSNMR) spectroscopy in magnetic fields of up to 21.1 T. The quadrupolar and chemical shift (CS) tensor parameters for halide ions (Cl–, Br–, I–) which act as electron density donors in the halogen bonds of these compounds are measured to provide insight into the possible relationship between halogen bonding and NMR observables. The NMR data for certain series of related compounds are strongly indicative of when such compounds pack in the same space group, thus providing practical structural information. Careful interpretation of the NMR data in the context of novel and previously available X-ray crystallographic data, and new gauge-including projector-augmented-wave density functional theory (GIPAW DFT) calculations has revealed several notable trends. When a series of related compounds pack in the same space group, it has been possible to interpret trends in the NMR data in terms of the strength of the halogen bond. For example, in isostructural series, the halide quadrupolar coupling constant was found to increase as the halogen bond weakens. In the case of a series of haloanilinium bromides, the 81Br isotropic chemical shift and CS tensor span both decrease as the bromide–halogen XB is weakened. These trends were reproduced using both GIPAW DFT and cluster-model calculations of the bromide ion magnetic shielding tensor. Such trends are particularly exciting given the well-known role that NMR has played historically in the characterization of hydrogen bonding.
Investigation of glow discharge plasma for surface modification of polypropylene (2003)

Abstract Material surface properties of polymers, plastics, ceramics and textiles can be modified by atmospheric or low‐pressure glow discharge plasma. The aim of the present work is to study the surface modification of biaxially oriented polypropylene (BOPP) film in order to improve its hydrophilic and wetting properties. In this article we used low‐pressure, low‐temperature oxygen plasma for the surface treatment of BOPP. Scanning electron microscopy indicates that plasma treatment causes mainly physical changes by creating microcraters and roughness on the surface and increasing surface friction. Attenuated total reflectance infrared spectra show oxygen‐containing groups such as OH at 3513 cm −1 and CO at 1695 cm −1 . Microscopic investigations of water droplets on BOPP (treated, untreated) show that the interfacial adhesion of treated surfaces is increased. Copyright © 2003 John Wiley &amp; Sons, Ltd.
406 Clinical Validation of AI Scoring in Adult and Pediatric Clinical PSG Samples Compared to Prospective, Double-Blind Scoring Panel (2021)

Abstract Introduction Despite an appreciable rise in sleep wellness and sleep medicine A.I. research publications, public data corpuses, institutional support, and health A.I. research funding opportunities, the availability of controlled-retrospective, hybrid-retrospective-prospective, and prospective-RCT quality clinical validation study evidence is limited with respect to their potential clinical impact. Furthermore, only a few practical examples of A.I. technologies are validated, in use today clinically, and widely adopted, to assist in sleep diagnoses and treatment. In this study, we contribute to this growing body of clinical A.I. validation evidence and experimental design methodologies with an interoperable A.I. scoring engine in Adult and Pediatric populations. Methods Stratified random sampling with proportionate allocation was applied to a database of N&amp;gt;10,000 retrospective diagnostic clinical polysomnography (PSG), selected by evidence grading standards, with controls applied for OSA severity, diagnoses; sleep, psychiatric, neurologic, neurodevelopmental, cardiac, pulmonary, metabolic disorders, medications; benzodiazepines, antidepressants, stimulants, opiates, sleep aids, demographic groups of interest; sex, adult age, pediatric age, BMI, weight, height, and patient-reported sleepiness, to establish representative N=100 Adult and N=100 Pediatric samples. Double Blinded scoring was prospectively collected for each sample by 3 experienced RPSGT certified sleep technologists randomized from a pool of 9 scorers. Sensitivity (PA), Specificity (NA), Accuracy (OA), Kappa (K), and 95% Bootstrap CI’s are presented for sleep stages, OSA/CSA, hypopnea 3%/4%, arousals, limb movements, Cheyenne-Stokes respiration, periodic breathing, atrial fibrillation, and other events, and normative, mild, moderate, and severe OSA categories for global-AHI and REM-AHI. Results for Sleep Staging and OSA Severity Diagnostic Accuracy are summarized. Results A.I. scoring performance meet but in most cases exceeded initial clinical validation study (N=72 Adults, 2017) PA, NA, OA, K point-estimates and confidence-interval results for the 26 event types and 8 AHI-categories evaluated. The Adult sample showed 87%/94% Sensitivity/Specificity across all stages (Wake/N1/N2/N3/REM) and 94%/96% Sensitivity/Specificity for AHI&amp;gt;=15. The Pediatric sample showed 87%/93% Sensitivity/Specificity staging, 89%/98% Sensitivity/Specificity AHI&amp;gt;=15. Observed Accuracy was &amp;gt;90% for Adults and Pediatrics all 26 events and 7 AHI-categories analyzed, except REM-AHI&amp;gt;=5 (85%/82% Adults/Pediatrics). Conclusion We provide clinical validation evidence that demonstrates interoperable A.I. scoring performance in representative Adult and Pediatric patient clinical PSG samples when compared to prospective, double-blind scoring panel. Support (if any):
Ensuring deterministic concurrency through compilation (2010)

Multicore shared-memory architectures are becoming prevalent but bring many programming challenges. Among the biggest is non-determinism: the output of the program does not depend merely on the input, but also on scheduling choices taken by the operating system. In this paper, we discuss and propose additional tools that provide determinism guarantees-compilers that generate deterministic code, libraries that provide deterministic constructs, and analyzers that check for determinism. Additionally, we discuss techniques to check for problems like deadlock that can result from the use of these deterministic constructs.
Twin Boys with Major Histocompatibility Complex Class II Deficiency but Inducible Immune Responses (1995)

The major histocompatibility complex (MHC) class II molecules are composed of two polypeptide chains (α and β). In humans the three distinct isotypes are designated HLA-DR, DP, and DQ. The different isotypes serve similar functions, and their expression on cells is regulated in coordinated fashion.1 MHC class II molecules are expressed on the surface of certain cells of the immune system, such as monocytes and macrophages, B cells, and dendritic cells, where they play an important part in the immune response.2 MHC class II deficiency is an autosomal recessive disease characterized by cellular and humoral immunodeficiency.3 Family studies show that . . .
Electroweak tests using leptonic decays of the Z° (1991)

Abstract LEP results characterizing the reactions e+e- → Z° → e+e-, μ+μ-, τ+τ- are presented. Measurements of the partial widths for these reactions, and of their differential cross sections as a function of polar angle permit a determination of electroweak parameters. Comparisons between these measured electroweak parameters and the Standard Model predictions are a precise test of the Standard Model. Alternatively, it can be assumed that the Standard Model is correct, in which case the data can be used to infer a mass for the top quark.
Pseiki: a blackboard framework for expectation-driven image interpretation (1989)

A fundamental goal of computer vision research is the development of systems capable of carrying out scene interpretation using knowledge of the expected scene. Here, we describe PSEIKI, a framework for expectation-driven interpretation of image data. PSEIKI performs expectation-driven processing by matching elements, such as edges and regions, detected in an image with model-elements from a supplied expected scene. PSEIKI builds abstraction hierarchies in image data using cues taken from the supplied abstractions in the expected scene. Hypothesized abstractions in the image data are geometrically compared with the known abstractions in the expected scene; the metrics used for these comparisons translate into belief values. The Dempster-Shafer formalism is used to accumulate beliefs for the synthesized abstractions in the image data. For accumulating belief values, a computationally efficient variation of Dempster's rule of combination is developed to enable the system to deal with the overwhelming amount of information present in most images. This variation of Dempster's rule allows the reasoning process to be embedded into the abstraction hierarchy by allowing for the propagation of belief values between elements at different levels of abstraction. PSEIKI has been implemented as a 2-panel, 5-level blackboard in OPS83. The operation and implementation of the blackboard's knowledge sources are described in detail. Control aspects of the blackboard's scheduler and distributed monitor are also described. Finally, an experiment in which PSEIKI was used to aid in the navigation of an autonomous mobile robot will be described. PSEIKI was used to provide sensory feedback to update the estimates of the robot's position and orientation as it traveled in a known environment.
Modeling of PN interleaved phase shifters for high speed silicon modulators (2014)

In this work, the modeling of phase shifters based in PN interleaved junctions is analyzed. Three different models based on different approximations are presented in details. Comparisons with previous published experimental data are presented, as well as a comparison and a discussion on the different models.
Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies (2022)

Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by the "always-on" pharmacological activities of therapeutic agents and the lack of efficient sonosensitizers. Herein, the development of semiconducting polymers as efficient sonosensitizers and further development of sono-immunotherapeutic nanobodies (SPN<sub>Ab</sub> ) for activatable cancer sono-immunotherapy are reported. Conjugation of anti-CTLA-4 antibodies onto the polymer nanoparticles through a <sup>1</sup> O<sub>2</sub> -cleavable linker affords SPN<sub>Ab</sub> with relatively low CTLA-4 binding affinity. Upon sono-irradiation, SPN<sub>Ab</sub> generates <sup>1</sup> O<sub>2</sub> not only to elicit a sonodynamic effect to induce immunogenic cell death, but also to release anti-CTLA-4 antibodies and trigger in situ checkpoint blockade. Such a synergistic therapeutic action mediated by SPN<sub>Ab</sub> modulates the tumoricidal function of T-cell immunity by promoting the proliferation of cytotoxic T lymphocytes and depleting immunosuppressive regulatory T cells, resulting in effective tumor regression, metastasis inhibition, durable immunological memory, and prevention of relapse. Therefore, this study represents a proof-of-concept sonodynamic strategy using semiconducting polymers for precise spatiotemporal control over immunotherapy.
Simulation of compression molding of long‐glass‐fiber‐reinforced thermoplastic sheets (1992)

Abstract An isothermal two‐dimensional shear‐thinning model of the compression molding of long‐glass‐fiber–reinforced thermoplastic is presented. A transverse isotropic behavior is introduced by considering two different pairs of power‐law coefficients. First ( K 1 , m 1 ) is linked to the shear deformations through the thickness and to the compression deformation; second ( K 2 , m 2 ) is associated to the expansion motions in the plane. K 2 is significantly greater than K 1 because of the influence of the glass mat structure, which resists stretching in the plane of the part. These coefficients are determined by fitting the computed and experimental mold closing forces in a circular isothermal compression‐molding test. The average velocity through the thickness is obtained by a variational method. Incompressibility is ensured by penalization. A finite element method is used, with a convected mesh and remeshing technique. The agreement between this model and experimental results (shape of the sample, mold closing force, pressure) performed on a rectangular mold is good.
Infection by Trypanosoma cruzi (2001)

The infective trypomastigote stage of Trypanosoma cruzi expresses a set of surface glycoproteins that are known collectively as Tc85 and belong to the gp85/trans-sialidase supergene family. A member of this family, Tc85-11, with adhesive properties to laminin and cell surfaces was recently cloned. In this report, the Tc85-11 domain for cell binding and its corresponding receptor on epithelial cell LLC-MK(2) are described. Using synthetic peptides corresponding to the Tc85-11 carboxyl-terminal segment, we show that the mammalian cell-binding domain colocalizes to the most conserved motif of the trypanosome gp85/trans-sialidase supergene family (VTVXNVFLYNR). Even though Tc85-11 binds to laminin, the 19-residue cell-binding peptide (peptide J) does not contain the laminin-binding site, because it does not bind to laminin or inhibit cell binding to this glycoprotein. The host cell receptor for the peptide was characterized as cytokeratin 18. Addition of anti-cytokeratin antibodies to the culture medium significantly inhibited the infection of epithelial cells by T. cruzi. Tc85-11 is a multiadhesive glycoprotein, encoding at least two different binding sites, one for laminin and one for cytokeratin 18, that allow the parasite to overcome the barriers imposed by cell membranes, extracellular matrices, and basal laminae to reach the definitive host cell. This is the first description of a direct interaction between cytokeratin and a protozoan parasite.
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies (2017)

Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose. However, the need for more physiologically realistic in vitro models has recently fueled the emerging field of tissue-engineered 3D cultures, also referred to as organs-on-chips, or microphysiological systems (MPSs). We have developed a novel fluidic platform that interconnects multiple MPSs, allowing PK studies in multi-organ in vitro systems along with the collection of high-content quantitative data. This platform was employed here to integrate a gut and a liver MPS together in continuous communication, and investigate simultaneously different PK processes taking place after oral drug administration in humans (e.g., intestinal permeability, hepatic metabolism). Measurement of tissue-specific phenotypic metrics indicated that gut and liver MPSs can be fluidically coupled with circulating common medium without compromising their functionality. The PK of diclofenac and hydrocortisone was investigated under different experimental perturbations, and results illustrate the robustness of this integrated system for quantitative PK studies. Mechanistic model-based analysis of the obtained data allowed the derivation of the intrinsic parameters (e.g., permeability, metabolic clearance) associated with the PK processes taking place in each MPS. Although these processes were not substantially affected by the gut-liver interaction, our results indicate that inter-MPS communication can have a modulating effect (hepatic metabolism upregulation). We envision that our integrative approach, which combines multi-cellular tissue models, multi-MPS platforms, and quantitative mechanistic modeling, will have broad applicability in pre-clinical drug development.