gebhart/patrepeval huggingface dataset:
SÍNTESIS Y CARACTERIZACIÓN DE NUEVOS CURCUMINOIDES HALOGENADOS (2013)

In this work a novel procedure of synthesis of compounds analogues to curcumin with halogens atoms in its structure is described, which can increase its solubility and biological activity. Four halogenated curcuminoids were obtained with great pharmacological interest, none of them reported in literature before. Synthesis was carried out by means of the aldol condensation assisted by microwaves of halogenated aromatic aldehydes and acetylacetona, using morpholine as basic catalyst, in absence of solvent, and the reaction just needed 1 min. The products were purified by treatment of the reaction mixture with methanol under ultrasound irradiation, followed by chromatographic column. All obtained compounds were characterized by infrared spectroscopy, nuclear magnetic resonance, quantitative elementary analysis and high resolution mass spectrometry. The RMN-1H data demonstrate in all structures of synthesized curcuminoids the enol form is the most favored.
Artificial intelligence-assisted quantification of COVID-19 pneumonia burden from computed tomography improves prediction of adverse outcomes over visual scoring systems (2023)

Quantitative pneumonia burden assessed using AI demonstrated higher performance for predicting clinical deterioration compared to current semi-quantitative scoring systems. Such an AI system has the potential to be applied for image-based triage of COVID-19 patients in clinical practice.
Inhibition of Interferon-γ Antiviral and Antiproliferative Activities by ras Oncogene Expression (1989)

In this study, we evaluated the effect of ras oncogene activation on cell response to interferons (IFNs). For this purpose, we treated NIH 3T3 murine fibroblasts transformed by transfection with K-, Ha-, or N-ras oncogenes, either mutated or amplified, for 24 hours with IFN-gamma or IFN-alpha. We evaluated cell response by measuring virus replication, [3H]thymidine incorporation, 2',5'-oligoadenylate synthetase activation, and class I antigen induction. Transformed cells were much less responsive to IFN-gamma antiviral and antiproliferative activities than normal NIH 3T3 cells. Similarly, the induction of 2',5'-oligoadenylate synthetase following IFN-gamma treatment was completely depressed in transformed cells. Only class I antigens, measured at the cell surface and mRNA levels, appeared partially inducible by IFN-gamma in ras-transformed cells. When the same cell lines were treated with IFN-alpha, we observed full response. Because both normal and ras-transformed NIH 3T3 cells were able to bind [125I]IFN-gamma with comparable Kd values (8.3 X 10(-11) M vs. 3 X 10(-11) M, respectively), these findings suggest that ras oncogenes may differentially impair IFN-gamma activities by affecting activation of IFN-inducible genes downstream from the receptor binding event.
Novel Synthesis of cis‐3,5‐Disubstituted Morpholine Derivatives. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Modeling Human Vestibular Responses during Eccentric Rotation and Off Vertical Axis Rotation (1995)

A mathematical model has been developed to help explain human multi-sensory interactions. The most important constituent of the model is the hypothesis that the nervous system incorporates knowledge of sensory dynamics into an "internal model" of these dynamics. This internal model allows the nervous system to integrate the sensory information from many different sensors into a coherent estimate of self-motion. The essence of the model is unchanged from a previously published model of monkey eye movement responses; only a few variables have been adjusted to yield the prediction of human responses. During eccentric rotation, the model predicts that the axis of eye rotation shifts slightly toward alignment with gravito-inertial force. The model also predicts that the time course of the perception of tilt following the acceleration phase of eccentric rotation is much slower than that during deceleration. During off vertical axis rotation (OVAR) the model predicts a small horizontal bias along with small horizontal, vertical, and torsional oscillations. Following OVAR stimulation, when stopped right- or left-side down, a small vertical component is predicted that decays with the horizontal post-rotatory response. All of the predictions are consistent with measurements of human responses.
Supplementary Tables S1-S6 from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia (2023)

&lt;p&gt;Supplementary Tables S1-S6 describing patient characteristics, gene lists, LSC signatures, and reagents.&lt;/p&gt;
A comparison study on thermal characterization of high power leds with different ceramic attach adhesives for automotive lighting applications (2014)

In general, the increased electrical current used to drive head lamp LEDs has focused more attention on the thermal paths in the packages. Consequently, the increase in the heat flux can cause thermal runaway and catastrophic failures, limiting the full exploitation of the LED chip technology. The present study aims to develop highly thermal conductive composite materials, based on aluminium nitride (AlN) epoxy composites, as ceramic attach thermal adhesive layer for high power LEDs. Two different polymer matrices were employed to compound the AlN filled epoxy composites; bisphenol-A diglycidyl ether (D1) epoxy resin and a cycloaliphatic compound (Cl). Comparing D1 and C1 with the control glue system, it was found that control glue performed the best. D1 performed the worst with highest thermal resistance in the application. The material properties of the glues and the thermal transient measurement of head lamp LEDs are discussed extensively in this paper.
School Strategies to Deal with Gangs (2002)

Analysis of the reasons why young people join or form criminal gangs indicates that gang membership is intimately related to peer interaction. Peer groups come in a wide range of shapes and sizes, and school is an important site for the incubation and sustainment of diverse peer networks. School experiences have long been associated with risk and protective factors pertaining to juvenile crime and gang-related behaviour. Factors such as low school commitment and low academic achievement are directly linked to potential deviancy, whether this be self-destructive behaviour (as with drug abuse) or antisocial group activity (such as gangs). On the other hand, factors such as encouragement of student participation in school decision-making can help foster pro-social interactions and relationships. This paper provides a brief overview of various anti-gang approaches and strategies used within a schooling context.
Persistence of influenza A/New Jersey/76 (Hsw1N1) antibody one year after vaccination. (1978)

Serum HI and neuraminidase-inhibiting (NI) antibody measurements were made at 3, 32 and 50 weeks after inactivated influenza Hsw1N1 vaccination of 438 adults in 1976. Although the highest postvaccination geometric mean HI titers were observed in persons greater than or equal to 52 years of age, the rate of antibody decline was similar in adults of all ages. In 14 children who had a seroconversion following two doses of whole virus or split virus vaccine, the geometric mean HI antibody titer was lower after the second vaccine dose than the peak titer observed in adults, and the decrease in titer was also more rapid by 4 to 7 months. One year after influenza Hsw1N1 vaccination of adults, the prevalence of homologous HI antibody greater than or equal to 40 was 71% to 97%, whereas only two of the 14 children maintained similar titers at 5 to 7 months. Neuraminidase-inhibiting antibody titer formation occurred more frequently in those without prevaccination NI antibody, but the rate of decline was also greatest in this initially seronegative group. The rate of antibody decline at one year in the population with preexisting antibody was similar to that observed for HI antibody decline in a primed population. Heterologous influenza A/Victoria/3/75 (H3N2) HI antibody formation occurred in 22% of adults aged 25 to 51 after Hsw1N1 vaccination and in 12% of those over the age of 51, but the rate of heterologous antibody decline was more rapid than that observed for homologous antibody.
Terahertz Kerr effect in gallium phosphide crystal (2014)

We report on the observation of the Kerr effect induced by an intense terahertz pulse in a &#x2329;100&#x232A; gallium phosphide crystal. The temporal and angular behaviors of the phase retardation have been measured and agree well with theoretical predictions. From these measurements, we extracted the two nonzero tensor elements of the third-order response function of the crystal in the terahertz range.
Depression, inflammation, and pain in patients with rheumatoid arthritis (2009)

Depression severity and inflammation were associated with each other and appeared to have independent effects on perceived pain. Therefore, a clinical approach that takes into account both the body and the mind could have benefits and could enable optimal pain control.
Jet impingement onto a cavity (2002)

Jet impingement onto surface finds wide application in industry. In laser processing an assisting gas jet is introduced either to shield the surface from oxidation reactions or initiating exothermic reaction to increase energy in the region irradiated by a laser beam. When an impinging gas jet is used for a shielding purpose, the gas jet enhances the convective cooling of the cavity surface. The convective cooling of the laser formed cavity surface can be simulated through jet impingement onto a cavity with elevated wall temperatures. In the present study, gas impingement onto a slot is considered. The wall temperature of the cavity is kept at elevated temperature similar to the melting temperature of the substrate material. A control volume approach is used to simulate the flow and temperature fields. The Reynolds Stress Turbulence model (RSTM) is employed to account for the turbulence. To examine the effect of cavity depth on the heat transfer characteristics, the depth is varied while keeping the cavity width constant. It is found that impinging jet penetrates into a cavity, which in turn, results in a stagnation region extending into the cavity. An impinging gas jet has considerable effect on the Nusselt number along the side walls of the cavity while the Nusselt number monotonically changes with varying cavity depth.
Construction of Noninterpenetrating and Interpenetrating (4-Fold and 8-Fold) 3-D Cd(II) Networks with Tris(1,2,4-triazol-4-yl)phenyl)amine Modulated by Aromatic Dicarboxylate Coligands (2016)

Three Cd(II)-based coordination polymers 1–3 with unique structures and topologies have been successfully constructed under solvothermal conditions by use of a newly designed N-containing rigid triangular ligand tris(4-(4H-1,2,4-triazol-4-yl)phenyl)amine (TTPA-4), wherein the structural interpenetration can be modulated by aromatic dicarboxylate coligands including thiophene-2,5-dicarboxylic acid (TDA) and terephthalic acid (TPA). Without using coligands, a noninterpenetrating porous 3-D network of 1 with nia topology was obtained. With the aid of the V-shaped TDA coligand, a 4-fold interpenetrating 3-D network of 2 resulted that is built from (2,3,7)-connecting (42.6)(44.6.88.104.124)(4)2 net. In the presence of the linear TPA auxiliary ligand, an 8-fold interpenetrating 3-D network of 3 was produced that is assembled by 3-connecting uninodal srs net. Particularly, compound 1 displays interesting dual function as the result of its unique structural attributes, which not only shows superb sensitivity for nitroaromatics (NACs) with phenolic group but also impressive removal capabilities of toxic Cr2O72– oxoanion pollutant from aqueous solution.
A cyclostationary feature detector (2002)

Cyclostationary models for communications signals have been shown in recent years to offer many advantages over stationary models. Stationary models are adequate in many situations, but they cause important features of the signal to be overlooked. One such important feature is the correlation between spectral components that many signals exhibit. Cyclostationary models allow this spectral correlation to be exploited. This paper presents a signal detector that exploits spectral correlation to determine the presence or absence of a cyclostationary signal in noise. The detector's probability of false alarm is analytically derived. Computer simulations verify that the analytical derivation is correct. The detector's receiver operating characteristic curves are determined from the simulation data and the analytical expression for the probability of false alarm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Autonomous Farming: Modeling and Control of Agricultural Machinery in a Unified Framework (2008)

Currently, there are significant challenges faced by the farming industry, not least of which are a reduction in the available labour workforce, and a more 'corporate' style of farming. Such factors demand an increase in farming efficiency and productivity. This paper looks forward to the not too distant future, where the realisation of autonomous farming will aid in the farming communities surviving as well as competing in the global market. In this work, the autonomous farm is seen as a complex system-of-systems, where there is necessarily a seamless integration of requirements, bringing together the areas of robotics for autonomous farming, and precision agriculture (PA), which deals with issues of agronomy. In essence, agricultural robotics uses on-farm sensing and control to actuate autonomous farm machinery with the aim of satisfying agronomy-based objectives. We initially describe a system-of-systems architecture, or unified framework, where a vital building block is the existence of two data sets used as links, or communication, between the various sub-systems. These data sets include a precision farming data set (PFDS) formed off-line before crop cultivation, containing spatially precise navigation data for any and all autonomous machinery, and a precision agriculture data set (PADS), which is a continually evolving entity consisting more of agronomy data in relation to the crop. Secondly, research undertaken in autonomous farm machinery is highlighted, where we present a foundation for the autonomous and robust control of articulated farm vehicles for real-time trajectory tracking in the presence of uncertain conditions. Preliminary results are shown, highlighting the autonomous control of vehicles for the operations of crop seeding and non-herbicidal weeding.
Effects of thromboxane synthase inhibition on in vivo release of inflammatory mediators in chronic ulcerative colitis. (1995)

These results suggest that ridogrel is an oral active selective inhibitor of thromboxane synthetase, which modifies the pattern of colonic eicosanoid generation in patients with chronic ulcerative colitis. Oral ridogrel may be a useful treatment for patients with non-severe ulcerative colitis, although specific indications require further studies.
LAYOUT OF A NEW EXPERIMENTAL STORAGE RING NESR AT GSI (2002)

A new experimental storage ring (NESR) is part of the new beam facility proposed recently for GSI. The NESR will serve experiments with rare isotopes as well as atomic physics experiments. Additionally the NESR shall be capable to accumulate 7×10 10 antiprotons per hour by applying stochastic cooling. The lattice has to provide maximum space for the different experimental installations and has also to fulfill the requirements of the stochastic cooling system. This contribution presents the conceptual design as well as lattice studies relevant for the different tasks of the ring and first beam dynamic calculations.
Wear Minimization for Cuckoo Hashing: How Not to Throw a Lot of Eggs\n into One Basket (2014)

We study wear-leveling techniques for cuckoo hashing, showing that it is\npossible to achieve a memory wear bound of $\\log\\log n+O(1)$ after the\ninsertion of $n$ items into a table of size $Cn$ for a suitable constant $C$\nusing cuckoo hashing. Moreover, we study our cuckoo hashing method empirically,\nshowing that it significantly improves on the memory wear performance for\nclassic cuckoo hashing and linear probing in practice.\n
Glutamate receptor‐mediated ischemic injury of premyelinated central axons (2009)

NMDA receptor-mediated injury to oligodendrocyte processes navigating along small premyelinated axons precedes damage to the underlying axon, a phenomena that is lost following radial expansion and subsequent oligodendrocyte ensheathment.
Agents for the masses (1999)

Is it possible to make development of sophisticated agents simple enough to be practical? This article discusses the authors' theoretical and tool-creation efforts to answer that question in the affirmative. Building sophisticated agent-based systems of the future will require research advances on at least three fronts: we must continue work on agent theory so that many currently unanswered questions about the scope and limitations of alternative approaches to agent design can be addressed; we must make agent frameworks and infrastructure powerful, interoperable, and secure enough to support robust large-scale coordinated problem-solving activity; and we must develop new sorts of tools to help non-specialists unlock the power of agent technology.
Avalanche photodiodes and quenching circuits for single-photon detection (1996)

Avalanche photodiodes, which operate above the breakdown voltage in Geiger mode connected with avalanche-quenching circuits, can be used to detect single photons and are therefore called singlephoton avalanche diodes SPAD's. Circuit configurations suitable for this operation mode are critically analyzed and their relative merits in photon counting and timing applications are assessed. Simple passive-quenching circuits (PQC's), which are useful for SPAD device testing and selection, have fairly limited application. Suitably designed active-quenching circuits (AQC's) make it possible to exploit the best performance of SPAD's. Thick silicon SPAD's that operate at high voltages (250-450 V) have photon detection efficiency higher than 50% from 540- to 850-nm wavelength and still ~3% at 1064 nm. Thin silicon SPAD's that operate at low voltages (10-50 V) have 45% efficiency at 500 nm, declining to 10% at 830 nm and to as little as 0.1% at 1064 nm. The time resolution achieved in photon timing is 20 ps FWHM with thin SPAD's; it ranges from 350 to 150 ps FWHM with thick SPAD's. The achieved minimum counting dead time and maximum counting rate are 40 ns and 10 Mcps with thick silicon SPAD's, 10 ns and 40 Mcps with thin SPAD's. Germanium and III-V compound semiconductor SPAD's extend the range of photon-counting techniques in the near-infrared region to at least 1600-nm wavelength.
ChemInform Abstract: Influence of Oxygen Partial Pressure and Oxygen Content on the Wettability in the Copper—Oxygen—Alumina System. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pushing the lithography limit: applying inverse lithography technology (ILT) at the 65nm generation (2006)

This paper presents the results of applying ILT to SMIC's first 65nm tape out. ILT mathematically determines the mask features that produce the desired on-wafer results for best pattern fidelity, largest process window or an desired combination of both. SMIC applied this technology to its first 65nm tape-out to study its performance and benefits for deep sub-wavelength lithography. SMIC selected 3 SRAM designs as the first set of test cases, because SRAM bit-cells contain features which are lithographically challenging. Firstly, three experiments were performed to optimize the illumination and mask design of a pair of layers by optimizing exposure energy, enabling SRAF, and enforcing mask constraints. Secondly, mask manufacturability (including fracturing and writing time) and wafer print performance of ILT was studied. Thirdly, mask patterns generated by both conventional Optical Proximity Correction (OPC) and ILT, both using only their optical models, were placed on the mask side-by-side. The results demonstrated that ILT achieved better CD accuracy and produced significantly larger process window than conventional OPC.
Knockout ofArfrp1leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells (2006)

ADP-ribosylation factor related protein 1 (ARFRP1) is a member of the ARF-family of GTPases which operate as molecular switches in the regulation of intracellular protein traffic. Deletion of the mouse Arfrp1 gene leads to embryonic lethality during early gastrulation, suggesting that ARFRP1 is required for cell adhesion-related processes. Here we show that ARFRP1 specifically controls targeting of ARL1 and its effector Golgin-245 to the trans-Golgi. GTP-bound ARFRP1 (ARFRP1-Q79L mutant) is associated with Golgi membranes and co-localized with the GTPase ARL1. In contrast, the guanine nucleotide exchange defective ARFRP1 mutant (ARFRP1-T31N) clusters within the cytosol. ARFRP1-T31N or depletion of endogenous ARFRP1 by RNA interference disrupts the Golgi association of ARL1 and of the GRIP-domain protein Golgin-245 and alters the distribution of a trans-Golgi network marker, syntaxin 6. In contrast, the targeting of two other Golgi-associated proteins, GM130 and giantin, was unaffected. Furthermore, in Arfrp1-/ - embryos ARL1 dislocated from Golgi membranes whereas it was associated with intracellular membranes in wild-type embryos. These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention. (1990)

Recombinant human immunodeficiency virus type 1 reverse transcriptase has been used to investigate the process of dimer formation and the properties of the different mono- and dimeric forms of the enzyme. The studies show that reverse transcriptase activity is exclusively confined to the dimeric forms. As we also demonstrate, the association rate constant between the monomers is relatively low so that the dimer-monomer equilibrium is very slowly established. This offers a new and potentially interesting target for antiviral chemotherapy with presumably higher specificity than the currently used nucleoside analogs (Yarchoan, R., Mitsuya, H., Myers, C.E., and Broder, S. (1989) N. Eng. J. Med. 321, 726-738), which in their active triphosphorylated form are also inhibitors of cellular polymerases.
Constituents of Rosaceous Plants. I. Structures of New Triterpenoids from Cowania mexicana. (2021)

In our search for possible anti-tumor-promoters, we carried out an investigation of the leaves and branches of Cowania mexicana D. DON (Rosaceae). Two new cucurbitane type triterpenes, 15-oxo-cucurbitacin F (3) and 15-oxo-23, 24-dihydrocucurbitacin F (4), were isolated together with cucurbitacin F (1) and 23, 24-dihydrocucurbitacin F (2). These triterpenes were inhibitors of Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate, a well-known tumor-promoter. The structures of 3 and 4 were determined from 2D-NMR spectral data and difference NOE experiments.