gebhart/patrepeval huggingface dataset:
High-pressure synthesis of ferromagnetic Mn3Ge with the Cu3Au-type structure (2002)

A new intermetallic compound, Mn3Ge, has been synthesized by direct reaction of elemental components at 6.2 GPa and 1000°C for 30 min using a belt-type high-pressure apparatus. The compound crystallizes into a cubic structure with the space group Pm3m, namely the L12-type (Cu3Au-type) structure. The structure was refined by Rietveld analysis of the powder x-ray diffraction data and the lattice constant was determined as a = 0.380 19(3) nm. The compound shows metallic conductivity and ferromagnetism with a Curie temperature of 400 K.
2-HEMA-free Dentin Bonding System to Prevent Contraction Gap. (1998)

The effects of 2-hydroxyethyl methacrylate (2-HEMA) both in the primer and in the commercial dentin bonding agent on the efficacy of the dentin bonding system was evaluated by measuring the polymerization contraction gap width of a commercial resin composite restored in a cylindrical dentin cavity prepared in an extracted human molar. Contraction gap formation was prevented in the group of the EDTA-conditioning followed by glyceryl mono-methacrylate, ethylene glycol and 1,6-hexanediol priming regardless of the 2-HEMA content in the dentin bonding agent containing 10-methacryloxydecyl dihydrogen phosphate. However, gap formation could not be prevented completely by the 2-HEMA priming. Therefore, it was possible to conclude that 2-HEMA was neither essential in the primer nor in the dentin bonding agent because of its low bonding efficacy and the resulting side effects on skin tissue as a delayed allergic reaction.
A HIGH YIELD, SELECTIVE SYNTHESIS OF 1,3,5-TRIMETHOXYBENZENE (2003)

(2003). A HIGH YIELD, SELECTIVE SYNTHESIS OF 1,3,5-TRIMETHOXYBENZENE. Organic Preparations and Procedures International: Vol. 35, No. 2, pp. 225-227.
Genetic interactions and dosage effects of Polycomb group genes in mice (1998)

In Drosophila and mouse, Polycomb group genes are involved in the maintenance of homeotic gene expression patterns throughout development. Here we report the skeletal phenotypes of compound mutants for two Polycomb group genes bmi1 and M33. We show that mice deficient for both bmi1 and M33 present stronger homeotic transformations of the axial skeleton as compared to each single Polycomb group mutant, indicating strong dosage interactions between those two genes. These skeletal transformations are accompanied with an enhanced shift of the anterior limit of expression of several Hox genes in the somitic mesoderm. Our results demonstrate that in mice the Polycomb group genes act in synergy to control the nested expression pattern of some Hox genes in somitic mesodermal tissues during development.
Performance Benefits of Using Inerter in Semiactive Suspensions (2014)

This brief investigates the performance benefits of using inerter in semiactive suspensions. A novel structure for semiactive suspensions with inerter, which consists of a passive part and a semiactive part, is proposed. Six semiactive suspension struts, each of which employs an inerter in the passive part and a semiactive damper in the semiactive part, are introduced. Two suboptimal control laws named clipped optimal control and steepest gradient control laws are derived to control the damping coefficient in the semiactive part. Extensive simulations with respect to different choices of weighting factors and suspension static stiffnesses are conducted based on both a quarter car model and a full car model. The results show that, compared with the conventional semiactive suspension strut, the overall suspension performance can be significantly improved using inerters, including ride comfort, suspension deflection, and road holding. Comparative studies between these two suboptimal control laws and between these semiactive struts are also carried out to facilitate future practical application of the proposed semiactive suspensions with inerter.
Common detectors for shaped offset QPSK (SOQPSK) and Feher-patented QPSK (FQPSK) (2005)

Symbol-by-symbol detection of SOQPSK and FQPSK using detectors designed for offset QPSK represents a simple common detector architecture for these two interoperable waveforms. Unfortunately, this detection method results in a 2 dB loss in bit error rate performance. This paper describes detection methods for recovering this loss without the need for knowing which modulation is used by the transmitter. An equivalent cross-correlated trellis-coded quadrature modulation (XTCQM) representation for SOQPSK is developed which forms the basis of a common TCM detector. An equivalent CPM representation for FQPSK is developed which forms the basis for a common CPM detector. The common XTCQM detector performs slightly better than the common CPM detector, but achieves this gain at the expense of higher complexity
LibGuides: Reference: Reference Service (2012)

Find everything you need to know about Reference, popular resources, tools and tips! Reference Basics, Ethics, and Service Guidelines
Alterations in plasma endocannabinoids (eCB) in 4-week abstinent alcoholics: A biological marker for hedonic tone? (2007)

The relationship between 30 days moderate amount of beer, wine and spirit administration and oxidative stress, biochemical and nutritional status parameters were studied in healthy male humans.Forty subjects with a mean alcohol consumption of 30 10 g per day were randomly divided into 3 experimental and 1 control group, 10 subjects each.After 2 weeks of total abstinence from alcohol, 40 g of ethanol per day were administered at the 2 main meals for 30 days.The amount of alcohol was administered by beer (group A), wine (group B) and spirit (group C); controls (group D) maintained abstinence from alcohol during the experimental period.Lipoperoxidation marker [malondyaldeide (MDA)], plasma antioxidant status [adenosine triphosphate (ATP), reduced glutathione (GSH), alpha-tocopherol (E-vitamin)], and the main blood parameters including total cholesterol, triglicerydes, HDL-cholesterol and liver parameters were performed at the start (T0) and at the end (T1) of the study.Body composition was assessed in all subjects by both anthropometry and bioimpedance (BIA) at T0 and T1.Controls did not present any signifi cant change in the assessed parameters at T1.At T1 a signifi cant increase in MDA in group A (+9.5%; p < 0.05), B (+19.0%; p < 0.05) and C (+7.3%; p < 0.05), a signifi cant decrease of GSH in group A ( -4.2%; p < 0.05), B ( -5.1%; p < 0.05) and C ( -9.0%; p < 0.05), of E vitamin in group A ( -14.5%; p < 0.05), B ( -32.4%; p < 0.05) and C ( -17.6%; p < 0.05) and of ATP in group C ( -12.0%; p < 0.05) were observed.Nutritional status did not present any signifi cant change in all the subjects evaluated, although fat mass resulted increased in groups A and B and decreased in group C at T1.In conclusions ethanol consumption leads to a decrease in plasmatic parameters of antioxidant status and an increase in lipoperoxidation.However some of these changes appear to be attenuated when ethanol is assumed in beer or wine.The micronutrients contained in these last beverages can account for the observed differences.
Taming Data Quality in AI-Enabled Industrial Internet of Things (2022)

We address the problem of taming data quality in artificial intelligence (AI)-enabled Industrial Internet of Things systems by devising machine learning pipelines as part of a decentralized edge-to-cloud architecture. We present the design and deployment of our approach from an AI engineering perspective using two industrial case studies.
Concurrent Segmentation and Localization for Tracking of Surgical Instruments (2017)

Real-time instrument tracking is a crucial requirement for various computer-assisted interventions. In order to overcome problems such as specular reflections and motion blur, we propose a novel method that takes advantage of the interdependency between localization and segmentation of the surgical tool. In particular, we reformulate the 2D instrument pose estimation as heatmap regression and thereby enable a concurrent, robust and near real-time regression of both tasks via deep learning. As demonstrated by our experimental results, this modeling leads to a significantly improved performance than directly regressing the tool position and allows our method to outperform the state of the art on a Retinal Microsurgery benchmark and the MICCAI EndoVis Challenge 2015.
Abstract 022: Higher Baseline Progenitor Cell Counts in Familial Hypercholesterolemic Patients Compared to Healthy Controls (2013)

Background: Endothelial injury from exposure to cardiovascular risk factors leads to atherosclerosis, however, an endogenous response to vascular injury characterized by circulating progenitor cells (CPCs) contributes to endothelial repair and regeneration. Although CPCs are known to be inversely related to cardiovascular risk, it is uncertain whether these risk factors are also a stimulus for CPC mobilization. We measured the number of CPCs in patients with familial hypercholesterolemia (FH) and compared them to patients with hyperlipidemia and healthy controls, with the hypothesis that CPC levels would be modulated by FH. Methods: Eight patients with FH on statin therapy (mean age, 48 ± 17 years) were compared with 16 age- and gender-matched hyperlipidemic patients on statin therapy, and 16 healthy volunteers. CPCs were analyzed using flow cytometry (BD FACS Canto II) for mononuclear cell (CD45dim) surface expression of CD34 and a combination of VEGF2R, CD133, and CXCR4 epitopes. Results are expressed as means ± SD or as proportions, and analysis of variance was used to detect differences between the three groups. Results: FH patients had higher circulating numbers of CD34+/CD133+ cells compared to hyperlipidemic (1.49 ± 1.01 vs. 0.88 ± 0.52 cells/µL, p = 0.04, respectively) and healthy counterparts (0.97 ± 0.61 cells/µL, p = 0.08). Similarly, FH subjects also had higher circulating levels of CD34+/CD133+/CXCR4+ cells compared to both the hyperlipidemic (0.68 ± 0.36 vs. 0.30 ± 0.22 cells/µL, p = 0.002, respectively) and healthy group (0.32 ± 0.25 cells/µL, p = 0.003). Conclusions: CPC counts, particularly of early CPCs characterized by CD133, and also those expressing the homing receptor, CXCR4, are higher in FH patients compared to age- and gender-matched healthy controls and patients with hyperlipidemia, independent of statins. This suggests an activation of reparative and regenerative reserve in FH subjects. The increased level of CPCs in FH subjects compared to hyperlipidemic patients may be a collective result of a higher level of lipid burden, lower therapeutic response to anti-hyperlipidemic pharmacotherapy, and chronic immune-activation due to ongoing subclinical endothelial injury in FH patients.
Glia inhibition suppresses chemotherapy-induced neuropathic pain in the rat (2014)

Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for advanced colorectal cancer. The dose-limiting toxicity of this compound is the development of a peripheral neuropathy. Recently, we described a characteristic glia activation profile in the presence of oxaliplatin-dependent neuropathic pain in the rat. In the present study, aimed to evaluate the glia role in neuropathy induced by oxaliplatin, we continuosly infused in the rat, by intrathecal route, minocycline, a tetracycline derivative that specifically inhibits microglia, or fluorocitrate, an astrocyte metabolic inhibitor of the citric acid cycle. Both compounds were able to significantly reduce oxaliplatin-dependent pain, when evaluated as an increase on suprathreshold stimulation (hyperalgesia-related measure) or as a decrease in pain threshold (allodynia-related measure) [1]. In the dorsal horn of the lumbar spinal cord minocycline was able to reduce in a time-dependent manner the Iba1 positive cell increase evoked by the anticancer treatment. Similarly fluorocitrate-treated animals showed a decreased in GFAP-positive cell with respect to the oxaliplatin-treated group. Minocycline and fluorocitrate did not show cross-action on astrocyte and microglia, respectively. The morphometric determinations performed on the DRG neurons evidenced that oxaliplatin decreased the soma area of the medium (600-1200 μm2) and large neurons (&gt;1200 μm2) as well as the incidence of eccentric nucleoli and of multinucleolated neurons were significatively increased in oxaliplatin treated rats. Neither minocycline nor fluorocitrate were able to prevent nervous tissue alteration. In summary, these data highlight the central role of glia cell in oxaliplatin-dependent neuropathic pain. On the contrary, glia inhibition does not induce neurorestorative processes suggesting the need of glia signalling modulation to obtain at the same time pain relief and neuroprotection.
Room Temperature Reduction of CO2 to Methanol by Al-Based Frustrated Lewis Pairs and Ammonia Borane (2010)

AlX(3) (X = Cl or Br) and PMes(3) (Mes = 2,4,6-C(6)H(2)Me(3)) react to form weak Lewis adducts but also react with CO(2) to give Mes(3)P(CO(2))(AlX(3))(2) (X = Cl; Br). These species react rapidly with excess ammonia borane at room temperature to give CH(3)OH upon quenching with water.
Mango: A Parser Generator for Self (2008)

: Mango is a parser generator that is included in Release 3.0 of the Self system. Mango goes beyond LEX/YACC in several respects. First, Mango grammars are structured, thus easier to read and map onto parse trees. Second, Mango parsers automatically build parse trees rather than merely provide hooks for calling low-level reduce actions during parsing. Third, Mango automatically maintains invariance of the structure of parse trees, even while grammars are transformed to enable LR parsing. Fourth, Mango and the parsers it generates are completely integrated in the Self object world. In particular, a parser is an object. Unlike YACC, several independent parsers can co-exist in a single program. We show how to generate a Mango parser and how to use it by means of an example: a simple expression language. Furthermore, we show how to add semantic properties to the parse trees that the Mango parser produces. Mango is a realistic tool. A parser for full ANSI C was built with Mango. email addr...
High-energy ultra-short pulses from pure-quartic solitons (2017)

Conventional optical solitons are remarkably stable pulses that arise from the balance of the nonlinearity and the anomalous quadratic dispersion in the medium in which they propagate, such as optical fibres [1] or silicon chips [2], Due to their self-reinforced stability, they are ideal candidates to generate transform-limited pulses from simple laser architectures [3], However, generating ultrashort high-energy pulses from soliton lasers is difficult, due to the spectral sideband generation of periodically perturbed solitons [4], which limits the shortest width, and the soliton energy scaling, which limits the energy at a given width. Consequently, laser architectures had to become more complex, with additional recompressing stages [5], Here, by means of experimental measurements, nonlinear Schrödinger equation (NLSE) simulations, and analytical developments, we show that the recently discovered pure-quartic solitons (PQS) [6] have the potential to outperform conventional solitons in yielding high-energy ultrashort pulses and bring soliton lasers back to the forefront of ultrafast laser research.
Overexpression of caspase recruitment domain (CARD) membrane‐associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B‐cell lymphoma (2005)

The overexpression of CARMA1 and CARD9 presumably is associated with the development or progression of gastric B-cell lymphoma, especially among patients who have disease in which the pathogenesis is not related to H. pylori.
Development of a capillary flow-cell for the infrared spectroscopy in gas phase using a hollow core fiber, and its application to the qualitative analysis of hydrochloric acid (2014)

A hollow core fiber was utilized as a capillary flow-cell for the infrared spectroscopy in gas phase that has the 1 m optical length and requires the sample volume of 2 ml. The system was applied to the qualitative analysis of hydrochloric acid. As a result, the specific spectrum of hydrochloric gas was successfully obtained at 10 times higher absorbance compared with an ordinary gas cell with 10 cm optical length. The capillary flow cell system developed in the present study can be a powerful tool in forensic chemistry for the analysis of hydrochloric acid and other volatile toxic substances.
Outcome of children born out of pregnancies complicated by unexplained polyhydramnios (2007)

Our aim was to assess the long-term outcomes of infants born out of a pregnancy complicated by unexplained polyhydramnios. We retrospectively analysed a cohort of 173 singleton pregnancies with polyhydramnios. There were 24 singletons with unexplained polyhydramnios, defined as polyhydramnios where prenatal testing was negative. Infants were examined by a paediatrician at a median age of 12 months (range 12-64 months). Of the 24 infants, 19 (79%) had a normal outcome. West syndrome, polyuria and pulmonary stenosis were diagnosed in three children during follow up, while there were two perinatal deaths. Paediatric follow up of children born out of pregnancies complicated by unexplained polyhydramnios should be carried out systematically.
Googling Yourself (2015)

Googling yourself should be done in moderation. Not everyone can self-Google, at least, not to any satisfying conclusion. For the best self-Google, having a distinctive name helps—something not too common but not too bizarre. This chapter shows how self-Googling could present some interesting results when people have the same name as you do. The advent of the Internet and Google has made the world a lot smaller, like a mote of dust on the tip of a pin in some alternate universe. In seconds, self-Googling can get you thinking about the person who has the same name as you do.
α-Galactosyl (Galα1-3Galβ1-4GlcNAc-R) epitopes on human cells: synthesis of the epitope on human red cells by recombinant primate α1,3galactosyltransferase expressed in E.coli (1995)

Developing methods for in vitro synthesis of the carbohydrate structure Galalpha1-3Galbeta1-4GlcNAc-R (termed the alpha-galactosyl epitope) on human tumour cells may be of potential clinical significance in cancer immunotherapy. Tumour vaccines with this epitope would be opsonized in vivo by the natural anti-Gal antibody, which is present in large amounts in humans, and which interacts specifically with alpha-galactosyl epitopes. Binding of anti-Gal to alpha-galactosyl epitopes on tumour cell membranes is likely to increase uptake of the cell membranes by antigen-presenting cells, such as macrophages, via the adhesion of the Fc portion of anti-Gal to Fc receptors on these cells. This, in turn, may increase processing and presentation of tumour-associated antigens by antigen-presenting cells, and induce an effective immune response against tumour cells with these antigens. The present study describes a method for the synthesis of alpha-galactosyl epitopes on human cells (red cells used as a model) by recombinant alpha1,3galactosyltransferase (rec. alpha1,3GT) expressed in bacteria. Escherichia coli was transformed with cDNA of the luminal portion of New World monkey rec. alpha1,3GT linked to six histidines (His)6 at the N-terminus. The enzyme produced by the bacteria was isolated from bacterial lysates on a nickel-Sepharose column and eluted with imidazole. This recombinant enzyme displayed acceptor specificity similar to that of rec. alpha1,3GT produced in COS cells. Red cells were pre-treated with sialidase for exposure of N-acetyllactosamine acceptors, then subjected to rec. alpha1,3GT activity. This enzyme synthesized at least 4 x 10(4) alpha-galactosyl epitopes/red cell. These epitopes were found to be accessible for binding of anti-Gal, as well as Bandeiraea simplicifolia IB4 lectin. It is argued that the method presented can be used for the synthesis of alpha-galactosyl epitopes on membranes of autologous tumour vaccines in humans.
Generation and Transplantation of Dopaminergic Neurons Derived from Embryonic Stem Cells (2007)

Human embryonic stem cells (hESCs) can be propagated as undifferentiated cells over multiple passages and thus offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Because of the important roles of dopaminergic (DA) neurons in modulating motor control, and in particular that the selective degeneration of DA neurons in midbrain cause the neurodegenerative disorder Parkinson's disease (PD), there has been significant interest in using hESC-derived DA neurons as a source of cells for drug screening, discovery and transplant purposes. Different strategies have evolved to generate appropriately mature DA neurons that have been purified and/or enriched by one of several selection techniques. In this manuscript we discuss recent results, review the remarkable progress that has been made in the field, and compare these results with those obtained from mouse ESCs (mESCs).
Analysis of explosives via microchip electrophoresis and conventional capillary electrophoresis: A review (2005)

The upsurge in terrorist activity has generated tremendous demand for innovative tools capable of detecting major industrial, military, and home-made (improvised) explosives. Fast, sensitive, and reliable detection of explosives in the field is a very important issue in nowadays. CE, especially in its miniaturized format (lab-on-a-chip), offers great possibilities to create portable, field deployable, rapidly responding, and potentially disposable devices, allowing security forces to make the important decisions regarding the safety of civilians. This article overviews the microchip and conventional capillary electrophoretic techniques for analysis of a wide variety of explosive compounds and mixtures.
Halomethyl-cobalt(bis-acetylacetonate) for the controlled synthesis of functional polymers (2015)

Novel organocobalt complexes featuring weak C-CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of α-halide functionalized and telechelic polymers in organic media or in water. Substitution of halide by azide allows derivatization of polymers using the CuAAC click reaction.
Evolution of a Biosynthetic Temporary Skin Substitute: A Preliminary Study. (2015)

PermeaDerm with variable porosity possesses all attributes and properties known to be important for a successful temporary skin substitute and enables the clinician to control porosity from essentially zero to what the wound requires. The ability of the clinician to minimize wound desiccation without fluid accumulation is related to the reduction of punctate scarring.
Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs (2017)

H<sub>2</sub>S is a gaseous molecule able to trigger a plethora of central physiological and pharmacological effects as antioxidant, pro- and anti-inflammatory, pro- and anti-nociceptive, neuromodulator, and cytoprotective. The polypharmacology of H<sub>2</sub>S depends on the wide variety of targets implicated, but, despite the efforts, the mechanisms of action that should clarify its activity are still not completely unrevealed. Nevertheless, many attempts to exploit the multifaceted profile of this molecule have already been accomplished and many chemical entities containing an H<sub>2</sub>S-releasing pharmacophore have been synthetized. Here we discuss recent investigations on multitarget molecules able to release H<sub>2</sub>S, with a particular focus on the combinations of "native drug" with moieties structurally able to release H<sub>2</sub>S and their applications as therapeutic tools in bone disease, gastrointestinal system and neurodegenerative disorders.
Theory of highly-strained InAs quantum well lasers grown on InP for optical communications at 2 µm (2022)

We present a theoretical analysis of highly-strained InAs quantum well lasers grown on InP for use in next-generation hollow-core fibre optical communications close to 2 µ m, and validate our calculations against recent experimental data.