gebhart/patrepeval huggingface dataset:
Abstract 965: Establishment of a Sunitinib resistant cell line from ccRCC by long term drug application. (2013)

Abstract Introduction: Sunitinib (SUN) acts as a multitargeted tyrosine kinase inhibitor (TKI) in the treatment of advanced renal cell carcinoma. It addresses predominantly the neo-angiogenic pathway by inhibition of proliferation and induction of apoptosis. But in clinical practice patients fail therapy. To elucidate the mechanism behind the failure of SUN we started to investigate the efficacy of SUN in long term cell culture studies using permanent cell lines representing ccRCC. Material and Methods: CAKI-1/2, A-498 and 786-O cell lines, normal fibroblasts and HUVEC were subjected to different concentrations of SUN for up to 5 days. Efficacy of SUN was monitored by quantification of viability (WST-1), apoptosis (CDD+), necrosis (LDH+) and proliferation (BrdU). Under long term SUN-treatment growth behavior was assessed by cell counting spanning a cultivation period of several weeks. miRNA profiling was performed by microarray analysis at different point within this schedule. Results: ccRCC cell lines offer a decrease in viability down to 40-60% at 2-5μM/L SUN dependent on cell-type and cell concentration as a result of f proliferation-inhibition. Endothelial cells and fibroblasts react more sensitive showing a growth inhibition between 80-90% compared to untreated controls. Long term application of SUN to these ccRCC-cells results in SUN-insensitive cell clones offering no inhibition of proliferation at 2-5μM/l drug. Specific miRNA expression changes were identified in insensitive cells. Conclusion: Drug resistance by a long term SUN treatment provides cell lines to study the molecular mechanisms underlying this phenomenon. We have shown that resistance is associated with miRNA alterations. 3D-combination of these cell lines together with endothelial cells and fibroblasts offer a powerful tissue-like model to develop new therapeutic schedules to overcome the failure of actual treatment. Citation Format: Gerhard Unteregger, Simone Krein, Anne Weiland, Michael Stoeckle, Kerstin Junker. Establishment of a Sunitinib resistant cell line from ccRCC by long term drug application. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 965. doi:10.1158/1538-7445.AM2013-965
Spectral feature-based nonlinear residual echo suppression (2013)

We propose a method for nonlinear residual echo suppression that consists of extracting spectral features from the far-end signal, and using an artificial neural network to model the residual echo magnitude spectrum from these features. We compare the modeling accuracy achieved by realizations with different features and network topologies, evaluating the mean squared error of the estimated residual echo magnitude spectrum. We also present a low complexity real-time implementation combining an offline-trained network with online adaptation, and investigate its performance in terms of echo suppression and speech distortion for real mobile phone recordings.
nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. (1990)

The nit-2 major nitrogen regulatory gene of Neurospora crassa turns on the expression of various unlinked structural genes that specify nitrogen-catabolic enzymes under nitrogen-limitation conditions. The nit-2 gene encodes a protein of 1036 amino acid residues with a single zinc finger and a downstream basic region that may make up a DNA-binding domain. The zinc-finger domain of the NIT2 protein was synthesized in two ways to examine its DNA-binding activity with gel-band-mobility shift and DNA-footprint experiments. The NIT2 protein binds to specific DNA recognition elements that are located upstream of nitrogen-regulated structural genes. Each recognition element contains at least two copies of a core sequence whose consensus is TATCTA.
Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of some Novel 2-Methylthio-3-Substituted Quinazolin-4-(3H)-ones (2004)

A variety of novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines, the starting material dithiocarbamate was synthesized from methylanthranilate. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, the compounds A1, A2, A3 and A4 shown more potent analgesic activity, and the compound A4 shown more potent anti-inflammatory activity than the reference diclofenac sodium.
Chiral recognition mass spectrometry: remarkable effects observed from the relative ion abundances of ternary diastereomeric complexes using electrospray ionization (2005)

The relative abundances of ternary diastereomeric complexes (composed each from a cinchonane-type chiral selector, a model chiral acid, and an alkali cation) are shown to change remarkably and fortuitously with variation in concentration and type of alkali metal using electrospray ionization-mass spectrometry and competitive binding analysis.
Nouvelles règles pour la chasse en forêt domaniale (2017)

National audience
DNA encoding for plant digalactosyldiacylglycerol galactosyltransferase and methods of use (2023)

The cDNA encoding digalactosyldiacylglycerol galactosyltransferase (DGD1) is provided. The deduced amino acid sequence is also provided. Methods of making and using DGD1 to screen for new herbicides and alter a plant's leaf lipid composition are also provided, as well as expression vectors, transgenic plants or other organisms transfected with said vectors.
Impact of Sequence Specificity of Spherical Nucleic Acids on Macrophage Activation in Vitro and in Vivo (2019)

The effects of spherical nucleic acid (SNA) gold nanoparticle conjugates on the activation of macrophages in vitro and release of cytokines in vivo were explored. Herein, we show that G-quadruplexes, the formation of which is enhanced on gold nanoparticle surfaces, elicit an increase in cytokine release from mouse and human macrophages and induce the upregulation of activation receptors as well as NO<sub>2</sub> production in vitro. Moreover, these G-rich SNAs can induce cytokine release when injected intravenously, though there were no severe, long-term effects observed. These results further reinforce the notion that nucleic acid sequence and structure play an important role in how SNAs interact in biological milieu and highlight a key design parameter.
Record-Low (0.1460 dB/km) Attenuation Ultra-Large Aeff Optical Fiber for Submarine Applications (2015)

Record-low attenuation of 0.1460 dB/km is measured on a silica-core fiber with 148 μm2 effective area. Other span loss characteristics are also discussed and quantified, such as ultra-low attenuation after cabling and splice loss reduction.
Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients. (1997)

It is feasible to administer repetitive cycles of one-quarter dose CTCb intensification with PBPC and G-CSF. Additional studies are required to determine whether multiple cycles of CTCb intensification might offer a therapeutic advantage over a single high-dose cycle.
On a Systematic Approach to some Properties of Special Functions (1986)

Journal Article On a Systematic Approach to some Properties of Special Functions Get access L. M. B. C. CAMPOS L. M. B. C. CAMPOS Instituto Superior Técnico1096 Lisboa Codex, Portugal Search for other works by this author on: Oxford Academic Google Scholar IMA Journal of Applied Mathematics, Volume 36, Issue 2, 1986, Pages 191–206, https://doi.org/10.1093/imamat/36.2.191 Published: 01 May 1986 Article history Received: 28 April 1985 Revision received: 18 November 1985 Published: 01 May 1986
Batching CSIDH Group Actions using AVX-512 (2021)

Commutative Supersingular Isogeny Diffie-Hellman (or CSIDH for short) is a recently-proposed post-quantum key establishment scheme that belongs to the family of isogeny-based cryptosystems. The CSIDH protocol is based on the action of an ideal class group on a set of supersingular elliptic curves and comes with some very attractive features, e.g. the ability to serve as a “drop-in” replacement for the standard elliptic curve Diffie-Hellman protocol. Unfortunately, the execution time of CSIDH is prohibitively high for many real-world applications, mainly due to the enormous computational cost of the underlying group action. Consequently, there is a strong demand for optimizations that increase the efficiency of the class group action evaluation, which is not only important for CSIDH, but also for related cryptosystems like the signature schemes CSI-FiSh and SeaSign. In this paper, we explore how the AVX-512 vector extensions (incl. AVX-512F and AVX-512IFMA) can be utilized to optimize constant-time evaluation of the CSIDH-512 class group action with the goal of, respectively, maximizing throughput and minimizing latency. We introduce different approaches for batching group actions and computing them in SIMD fashion on modern Intel processors. In particular, we present a hybrid batching technique that, when combined with optimized (8 × 1)-way prime-field arithmetic, increases the throughput by a factor of 3.64 compared to a state-of-the-art (non-vectorized) x64 implementation. On the other hand, vectorization in a 2-way fashion aimed to reduce latency makes our AVX-512 implementation of the group action evaluation about 1.54 times faster than the state-of-the-art. To the best of our knowledge, this paper is the first to demonstrate the high potential of using vector instructions to increase the throughput (resp. decrease the latency) of constant-time CSIDH.
Reflections of Cultural Values: A Content Analysis of Chinese Magazine Advertisements From 1982 and 1992 (1994)

This article, through content analysing a total of 572 Chinese magazine advertisements from 1982 and 1992, identifies ‘modernity’, ‘technology’ and ‘quality’ as three predominant cultural values manifest in Chinese advertising over the past ten years. Although advertisements for imported products were found to be the pace-setter for these three dominant values, their ‘leadership’ is being challenged by advertisements for joint venture products.This study also gauges the value changes in Chinese advertising. Results indicate that while the values less frequently used in 1992 advertisements are utilitarian in nature and centring around product quality, the values increasing in their occurrences are more symbolic and suggestive of human emotions. The group of symbolic values consists of those from eastern as well as western culture.
Photocatalytic Hydrogen Production from H2S using Nanostructured CNT blended CdZnS/Fe2O3Thin Film on Glass Substrate (2020)

Abstract A co-precipitation method was employed to prepare the CNT blended CdZnS/Fe 2 O 3 photocatalyst. Using the powder photocatalyst, the thin film of CNT blended CdZnS/Fe 2 O 3 photocatalyst over a glass substrate was prepared using the drop-casting method. The obtained thin film was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray analysis (EDAX), photoluminescence (PL), and hydrogen production activity studies in order to obtain information on their structural, morphology, chemical composition, optical and hydrogen production efficiency. The hydrogen production activity of catalyst or effective conversion of H 2 S into hydrogen (H 2 ) and sulfur (S) using thin-film photocatalyst was evaluated using a simulated sulfide solution. The results showed that 1 mg of CNT blended CdZnS/Fe 2 O 3 catalyst coated as thin film over glass substrate (4.69 cm 2 ) showed the highest hydrogen production value of 3180 μmol h −1 g −1 ; compared to that of 1 mg CNT blended CdZnS/Fe 2 O 3 powder of 2510 μmol h −1 g −1 . From the above results, it is concluded that the thin film form of photocatlyst produced more hydrogen than the powder form. This is attributed to the effective charge separation and increased specific surface area in thin film photocatalyst.
Gamma-ray imaging with germanium detectors (1993)

Externally segmented germanium detectors promise a breakthrough in gamma-ray imaging capabilities while retaining the superb energy resolution of germanium spectrometers. By combining existing position-sensitive detectors with an appropriate code aperture, two-dimensional imaging with 0.2-deg angular resolution becomes practical for a typical balloon experiment. Much finer resolutions are possible with larger separations between detectors and the coded aperture as would be applicable for space-based or lunar-based observatories. Two coaxial germanium detectors divided into five external segments have been fabricated and have undergone extensive performance evaluation and imaging testing in our laboratory. These tests together with detailed Monte Carlo modeling calculations have demonstrated the great promise of this sensor technology for future gamma-ray missions.
A Markovian analysis of hurricane transitions (2008)

The present study considers the random phenomenon that is hurricane tracking in terms of hurricane intensity as measured by hurricane category defined by the newly proposed scale outlined by Wooten and Tsokos, (2007); in conjunction with conditional and unconditional Markov chains. The bi-conditional Markov chains are defined by a previous pressure index and the hurricane stage; that is, before or after the storm reaches its peak intensity or wind speed.
Structural Dynamics of Troponin I during Ca2+-Activation of Cardiac Thin Filaments: A Multi-Site Förster Resonance Energy Transfer Study (2012)

A multi-site, steady-state Förster resonance energy transfer (FRET) approach was used to quantify Ca(2+)-induced changes in proximity between donor loci on human cardiac troponin I (cTnI), and acceptor loci on human cardiac tropomyosin (cTm) and F-actin within functional thin filaments. A fluorescent donor probe was introduced to unique and key cysteine residues on the C- and N-termini of cTnI. A FRET acceptor probe was introduced to one of three sites located on the inner or outer domain of F-actin, namely Cys-374 and the phalloidin-binding site on F-actin, and Cys-190 of cTm. Unlike earlier FRET analyses of protein dynamics within the thin filament, this study considered the effects of non-random distribution of dipoles for the donor and acceptor probes. The major conclusion drawn from this study is that Ca(2+) and myosin S1-binding to the thin filament results in movement of the C-terminal domain of cTnI from the outer domain of F-actin towards the inner domain, which is associated with the myosin-binding. A hinge-linkage model is used to best-describe the finding of a Ca(2+)-induced movement of the C-terminus of cTnI with a stationary N-terminus. This dynamic model of the activation of the thin filament is discussed in the context of other structural and biochemical studies on normal and mutant cTnI found in hypertrophic cardiomyopathies.
Lack of effect of chemokine receptor CCR2b gene polymorphism (64I) on HIV‐1 plasma RNA viral load and immune activation among HIV‐1 seropositive female workers in Abidjan, Côte d'Ivoire (2001)

The prevalence of the CCR2b-V64I mutation among human immunodeficiency virus (HIV)-seropositive and -seronegative female workers and the potential effect of heterozygosity of this mutation on HIV-1 plasma RNA viral load and markers of immune activation were assessed. CCR2b-V64I was detected by polymerase chain reaction, followed by restriction enzymes analysis; plasma viral load was measured by the Amplicor HIV-1 monitor assay and CD4(+) T-cell counts and markers of immune activation by standard three-color FACscan flow cytometry. Of the 260 female workers, 56 (21.5%) were heterozygous for CCR2b-V64I, and 8 (3%) were homozygous. Of the 99 HIV-seronegative female workers, 19 (19.2%) were heterozygous for the CCR2b-V64I mutation compared with 37 (23%) of the 161 HIV-seropositive FSW (P = 0.47). In a univariate analysis of viral load among HIV-seropositive FSW, no difference was noted between those heterozygous for or without the mutation; both groups had plasma viral loads of 5.0 log(10) copies/ml. After controlling for the effects of CD4(+) T-cell counts in a multivariate analysis, no significant difference was observed between the groups in viral load or in markers of immune activation. The data suggest that the presence of the CCR2b mutation has no effect on HIV-1 plasma viral load and markers of immune activation in our study population. The finding that the frequency of this mutation is similar in HIV-seropositive and -seronegative female workers suggests that its presence is not associated with increased risk of HIV infection.
Corrigendum: Association of CTLA-4 Gene Variants with Response to Therapy and Long-term Survival in Metastatic Melanoma Patients Treated with Ipilimumab: An Italian Melanoma Intergroup Study (2018)

Corrigendum on: 9Istituto Dermopatico dell’Immacolata IDI-IRCCS, Sant’Andrea Hospital, Sapienza University of Rome, Rome, ItalyClearly state the mistake being fixedIn the original article affiliation number 9 is wrong and should be corrected as follows:9Istituto Dermopatico dell’Immacolata IDI-IRCCS, Rome, ItalyThis error does not change the scientific conclusions of the article in any way.
Oxidative Synthesis of Amides and Pyrroles via Dehydrogenative Alcohol Oxidation by Ruthenium Diphosphine Diamine Complexes (2011)

A series of ruthenium complexes can perform the acceptorless dehydrogenation of diols as well as the reaction of amines and alcohols to form ester, lactam, and amide products. The ligand criteria necessary for high catalytic activity are identified to guide future catalyst development for amide formation from amines and alcohols. These complexes can be employed in a dehydrogenative Paal–Knorr pyrrole synthesis to give 2,5-dimethyl-N-alkylpyrroles.
Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis (2023)

Neurological deficits from a stroke can result in long-term motor disabilities, including those that affect walking gait. However, extensive rehabilitation following stroke is typically time limited. Establishing predictive biomarkers to identify patients who may meaningfully benefit from additional physical therapy and demonstrate improvement is important to improve the patients' quality of life. Detection of neuroplastic remodeling of the affected region and changes in the activity patterns excited while performing suitable motor tasks could have valuable implications for chronic stroke recovery. This protocol describes the use of a digitally controlled, magnetic resonance-compatible foot-induced robotic device (MR_COFID) to present a personalized foot-motor task involving trajectory following to stroke-affected subjects with gait impairment during functional magnetic resonance imaging (fMRI). In the task, foot flexion is performed against bi-directional resistive forces, which are tuned to the subject's strength in both the dorsiflexion and plantar flexion directions, while following a visual metronome. fMRI non-invasively uses endogenous deoxyhemoglobin as a contrast agent to detect blood oxygenation level-dependent (BOLD) changes between the active and resting periods during testing. Repeated periodic testing can detect therapy-related changes in excitation patterns during task performance. The use of this technique provides data to identify and measure biomarkers that may indicate the likelihood of an individual benefitting from rehabilitation beyond that which is currently provided to stroke patients.
Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids (2011)

Free carboxylic acids are converted into amides in moderate to high yields in the presence of a stoichiometric amount of trimethylaluminium and amines at 90 ˚C after 1 hour.
Fluorescent hexaaryl- and hexa-heteroaryl[3]radialenes: Synthesis, structures, and properties (2012)

The syntheses of three new [3]radialenes - hexakis(3,5-dimethylpyrazolyl)-, hexakis(3-cyanophenyl)-, and hexakis(3,4-dicyanophenyl)[3]radialene (1-3) - are reported. Compound 3 is obtained in five steps with an excellent yield of 76% in the key step. Compared to that, the respective steps of the syntheses of 1 and 2 result in lower yields. All compounds adopt a double bladed propeller conformation in solution. Compound 3 is considerably more electron deficient than previously reported hexaaryl[3]radialenes, with reduction potentials of -0.06 and -0.45 V in CH(2)Cl(2). The compounds mostly display red fluorescence with large Stokes shifts.
4-Mercaptoimidazoles derived from the naturally occurring antioxidant ovothiols 1. Antioxidant properties (2000)

4-Mercaptoimidazoles derived from the naturally occurring family of antioxidants, the ovothiols, were assayed for their antioxidant properties. These compounds are powerful HOCl scavengers, more potent than the aliphatic thiol N-acetylcysteine. They react slowly with hydrogen peroxide with second order rate constants of 0.13-0.89 M(-1)s(-1). Scavenging of hydroxyl radical occurs at a diffusion-controlled rate (k=2.0-5.0 x 10(10)M(-1)s(-1)) for the most active compounds, which are also able to inhibit copper-induced LDL peroxidation. The combination of radical scavenging and copper chelating properties may explain the inhibitory effects on LDL peroxidation. Two molecules of mercaptoimidazole can chelate a copper ion and form a square planar complex detected by EPR. Compounds bearing an electron-withdrawing group on position 2 of the imidazole ring are the most potent antioxidant molecules in this series.
Application of adaptive fuzzy controllers for the automation of medical devices (2012)

This paper describes an adaptive fuzzy control algorithm that may be used for the automation of medical devices. The automation system consists of a set of controllers containing the expertise of the physician and a main fuzzy controller that creates new rules based on this knowledge plus additional information about the patient. An adaptive mechanism evaluates the performance of the controller by using reference models and modifies its rules when needed. As a test case the automation of an extra-corporeal support system is presented, where a centrifugal pump speed is adjusted based on desired pressures and flow values.