gebhart/patrepeval huggingface dataset:
Differences in Laboratory Findings for Cerebrospinal Fluid Specimens Obtained from Patients with Meningitis or Encephalitis Due to Herpes Simplex Virus (HSV) Documented by Detection of HSV DNA (2002)

Laboratory findings for cerebrospinal fluid (CSF) specimens were correlated with clinical presentations and histories in 55 cases of encephalitis or meningitis due to herpes simplex virus (HSV), as determined by polymerase chain reaction (PCR)-based detection of HSV DNA. Sixteen patients (29%) had HSV encephalitis (HSVE), 3 had mild or "atypical" meningoencephalitis, 34 (64%) had HSV meningitis (HSVM), and 1 had disseminated neonatal HSV infection. CSF findings included elevated leukocyte counts and/or elevated CSF protein levels in all HIV DNA-positive specimens. CSF leukocyte and protein abnormalities were more pronounced in cases of HSVM than they are in cases of HSVE. Patients with HSVE who had only mild CSF abnormalities also had minimal numbers of erythrocytes in the CSF. Patients with HSVM were younger than were patients with HSVE and were predominantly female. Eleven patients with HSVM reported having prior episodes, and 5 reported a history of recurrent headaches. These findings suggest that milder forms of HSV infection of the central nervous system may be identified by PCR for HSV. Prescreening of CSF specimens for the presence of leukocytes or elevated protein level may improve test utilization.
Dislocations in GaAs17−xPx (1969)

Dislocations, their origins, and their effects on photoluminescence efficiency have been studied in GaAs1−xPx single crystals grown by vapor phase epitaxy. Dislocations were observed using etch pit, optical-transmission microscopy, and x-ray topography techniques. Two types of dislocations are grown into GaAs1−xPx epitaxial crystals. Near the GaAs (substrate)-GaAs1−xPx interface a high density (&amp;gt;108 cm−2) of pure edge dislocations with axes and Burgers vectors lying in the growth plane was observed. These originate from the lattice parameter mismatch between substrate and epitaxial layer. In the bulk GaAs1−xPx, a high density (∼106 cm−2) of dislocations was observed with 〈211〉 and 〈100〉 directions and Burgers vectors parallel to those of the mismatch dislocations. These dislocations originate from the mismatch dislocations at the substrate-epitaxial layer interface. The effect of dislocations on photoluminescence efficiency was studied by a novel technique. The photoluminescence was excited by focusing a He–Ne laser onto a 20-micron spot on the polished sample surface. The photoluminescence was observed through a microscope at ×400 magnification. It was found that the dislocations grown into the GaAs1−xPx are not intrinsically deleterious to the photoluminescence efficiency; however, in impure material, impurities segregate at dislocations causing a lowering of the luminescence efficiency in a region within one micron of the dislocation core.
Prävention von Infektionen und Thrombosen nach Splenektomie oder bei Funktionsverlust der Milz (2009)

Overwhelming Post-Splenectomy Infection (OPSI or PSS), most frequently caused by encapsulated Gram-positive pathogens, is a complication after splenectomy. Reasons for splenectomy include trauma, or malignant and non-malignant hematologic diseases. OPSI-inducing bacteria are mainly Streptococcus pneumoniae and less frequently Haemophilus influenzae, Neisseria meningitides and Gram-negative bacilli. There exist very efficient--albeit often neglected--strategies, how to prevent infections in patients after splenectomy. These include vaccination, prophylactic antibiotics (always for 3 years during childhood and adolescence) and prompt antibiotic treatment, if an infection is suspected. Patients need to know the nature and likelihood of PSS and they should seek immediate medical attention if they become ill or febrile. Each patient should carry at all times a letter or card documenting the splenectomy. With these measures and precautions, the PSS-risk can be significantly reduced or at best be completely avoided.
Novel N/sub 2/O-oxynitridation technology for forming highly reliable EEPROM tunnel oxide films (1991)

Ultrathin ( approximately=6 nm) oxynitrided SiO/sub 2/ (SiO/sub x/N/sub y/) films have been formed on Si
Computational Identification of Novel Family Members of MicroRNA Genes in &lt;italic&gt;Arabidopsis thaliana&lt;/italic&gt; and &lt;italic&gt;Oryza sativa&lt;/italic&gt; (2005)

MicroRNAs (miRNAs) are a class of endogenous small RNAs that play important regulatory roles in both animals and plants. miRNA genes have been intensively studied in animals, but not in plants. In this study, we adopted a homology search approach to identify homologs of previously validated plant miRNAs in Arabidopsis thaliana and Oryza sativa. We identified 20 potential miRNA genes in Arabidopsis and 40 in O. sativa, providing a relatively complete enumeration of family members for these miRNAs in plants. In addition, a greater number of Arabidopsis miRNAs (MIR168, MIR159 and MIR172) were found to be conserved in rice. With the novel homologs, most of the miRNAs have closely related fellow miRNAs and the number of paralogs varies in the different miRNA families. Moreover, a probable functional segment highly conserved on the elongated stem of pre-miRNA fold-backs of MIR319 and MIR159 family was identified. These results support a model of variegated miRNA regulation in plants, in which miRNAs with different functional elements on their pre-miRNA fold-backs can differ in their function or regulation, and closely related miRNAs can be diverse in their specificity or competence to downregulate target genes. It appears that the sophisticated regulation of miRNAs can achieve complex biological effects through qualitative and quantitative modulation of gene expression profiles in plants.
The fragmentation of the ions of nonan‐4‐one: A study by triple quadrupole mass spectrometry (1981)

Abstract The fragmentation pathways for the ions generated by electron impact from nonan‐4‐one have been studied using low energy collision induced dissociation in a triple quadrupole mass spectrometer. Over 400 fragmentation pathways have been identified. These results are compared with data from earlier ion kinetic energy spectrometry studies of nonan‐4‐one which employed metastable decompositions.
TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model (2019)

Genetic mutations in TBC1D24 have been associated with multiple phenotypes, with epilepsy being the main clinical manifestation. The TBC1D24 protein consists of the unique association of a Tre2/Bub2/Cdc16 (TBC) domain and a TBC/lysin motif domain/catalytic (TLDc) domain. More than 50 missense and loss-of-function mutations have been described and are spread over the entire protein. Through whole genome/exome sequencing we identified compound heterozygous mutations, R360H and G501R, within the TLDc domain, in an index family with a Rolandic epilepsy exercise-induced dystonia phenotype (http://omim.org/entry/608105). A 20-year long clinical follow-up revealed that epilepsy was self-limited in all three affected patients, but exercise-induced dystonia persisted into adulthood in two. Furthermore, we identified three additional sporadic paediatric patients with a remarkably similar phenotype, two of whom had compound heterozygous mutations consisting of an in-frame deletion I81_K84 and an A500V mutation, and the third carried T182M and G511R missense mutations, overall revealing that all six patients harbour a missense mutation in the subdomain of TLDc between residues 500 and 511. We solved the crystal structure of the conserved Drosophila TLDc domain. This allowed us to predict destabilizing effects of the G501R and G511R mutations and, to a lesser degree, of R360H and potentially A500V. Next, we characterized the functional consequences of a strong and a weak TLDc mutation (TBC1D24G501R and TBC1D24R360H) using Drosophila, where TBC1D24/Skywalker regulates synaptic vesicle trafficking. In a Drosophila model neuronally expressing human TBC1D24, we demonstrated that the TBC1D24G501R TLDc mutation causes activity-induced locomotion and synaptic vesicle trafficking defects, while TBC1D24R360H is benign. The neuronal phenotypes of the TBC1D24G501R mutation are consistent with exacerbated oxidative stress sensitivity, which is rescued by treating TBC1D24G501R mutant animals with antioxidants N-acetylcysteine amide or α-tocopherol as indicated by restored synaptic vesicle trafficking levels and sustained behavioural activity. Our data thus show that mutations in the TLDc domain of TBC1D24 cause Rolandic-type focal motor epilepsy and exercise-induced dystonia. The humanized TBC1D24G501R fly model exhibits sustained activity and vesicle transport defects. We propose that the TBC1D24/Sky TLDc domain is a reactive oxygen species sensor mediating synaptic vesicle trafficking rates that, when dysfunctional, causes a movement disorder in patients and flies. The TLDc and TBC domain mutations' response to antioxidant treatment we observed in the animal model suggests a potential for combining antioxidant-based therapeutic approaches to TBC1D24-associated disorders with previously described lipid-altering strategies for TBC domain mutations.
The positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the Bos taurus genome (2019)

&lt;p&gt;In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in a parent-of-origin specific manner.&amp;nbsp; This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs).&amp;nbsp; In the mouse and the human genomes, the known ICRs/gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes.&amp;nbsp; It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the DNMT3A and DNMT3L complex for processive methylation of the ICRs in one of the parental alleles.&amp;nbsp; Furthermore, while ZFP57 selectively binds a CpG-methylated hexameric DNA sequence, MLL1 and MLL2 associate with a set of nonmethylation CpG-rich motifs known as the MLL1 morphemes.&amp;nbsp; Both MLL1 and MLL2 regulate transcription by modifying lysine 4 in histone H3 producing H3K4me3 marks in chromatin. &amp;nbsp;&amp;nbsp;&lt;/p&gt; &lt;p&gt;This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the cow genome.&amp;nbsp; The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track.&amp;nbsp; To obtain and save a copy of the bed file, click on download at the top right corner of the page.&amp;nbsp; Alternatively, click &lt;a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=cow&amp;amp;db=bosTau8&amp;amp;position=chr29:50,145,001-50,152,000&amp;amp;hgt.customText=https://purr.purdue.edu/publications/3359/serve?v=1" target="_blank"&gt;&lt;em&gt;here&lt;/em&gt;&lt;/a&gt; to examine directly the listed positions at the UCSC genome browser.&amp;nbsp;&lt;/p&gt; &lt;p&gt;If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu.&lt;/p&gt;
VIPhyb, an Antagonist of Vasoactive Intestinal Peptide Receptor, Enhances Cellular Antiviral Immunity in Murine Cytomegalovirus Infected Mice (2013)

Vasoactive intestinal peptide (VIP) is a neuropeptide hormone that suppresses Th1-mediated cellular immunity. We previously reported that VIP-knockout (VIP-KO) mice have enhanced cellular immune responses and increased survival following murine cytomegalovirus (mCMV) infection in C57BL/6 mice. In this study, we tested whether treatment with a VIP receptor antagonistic peptide protects C57BL/6 and BALB/c mice from mCMV-infection. One week of daily subcutaneous injections of VIPhyb was non-toxic and did not alter frequencies of immune cell subsets in non-infected mice. VIPhyb administration to mCMV-infected C57BL/6 and BALB/c mice markedly enhanced survival, viral clearance, and reduced liver and lung pathology compared with saline-treated controls. The numbers of effector/memory CD8+ T-cells and mature NK cells were increased in VIPhyb-treated mice compared with PBS-treated groups. Pharmacological blockade of VIP-receptor binding or genetic blockade of VIP-signaling prevented the up-regulation of PD-L1 and PD-1 expression on DC and activated CD8+ T-cells, respectively, in mCMV-infected mice, and enhanced CD80, CD86, and MHC-II expression on conventional and plasmacytoid DC. VIPhyb-treatment increased type-I IFN synthesis, numbers of IFN-γ- and TNF-α-expressing NK cells and T-cells, and the numbers of mCMV-M45 epitope-peptide-MHC-I tetramer CD8+ T-cells following mCMV infection. VIP-treatment lowered the percentage of Treg cells in spleens compared with PBS-treated WT mice following mCMV infection, while significantly decreasing levels of serum VEGF induced by mCMV-infection. The mice in all treated groups exhibited similar levels of anti-mCMV antibody titers. Short-term administration of a VIP-receptor antagonist represents a novel approach to enhance innate and adaptive cellular immunity in a murine model of CMV infection.
Langmuir-Blodgett Films of Triazolehemiporphyrazines: Evidence for Molecular Organization (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLangmuir-Blodgett Films of Triazolehemiporphyrazines: Evidence for Molecular OrganizationS. Pfeiffer, C. Mingotaud, C. Garrigou-Lagrange, P. Delhaes, A. Sastre, and T. TorresCite this: Langmuir 1995, 11, 7, 2705–2712Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/la00007a060https://doi.org/10.1021/la00007a060research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cooperative transmission in poisson distributed wireless sensor networks: protocol and outage probability (2006)

We study cooperative wireless communications in the physical layer of a Poisson distributed wireless sensor network, where the spatial diversity of multiple relay nodes is utilized to improve the link performance. The tradeoff among network power consumption, spectral efficiency, outage probability, and sensor node density is discussed under the proposed cooperative transmission protocol for sensor networks (CTP-SN). CTP-SN is considered as a typical implementation of the two-phase cooperative transmission paradigm in wireless sensor networks. We derive an asymptotic upper bound for the capacity outage probability of CTP-SN. The bound is shown to be decreasing exponentially, when the sensor node density increases. Via the bound, we demonstrate that the cooperative protocol performs asymptotically much better than the non-cooperative direct transmission
High dose ion implantation in yttria-stabilized zirconia (1986)

Abstract High dose 56Fe implantations (15–110 keV) in oxygen ion conducting solid solutions of 0.86 Zr02-0.14 YO1.5 [ZY14] are used to introduce electronic conductivity. The Fe distribution in the target as a function of the various implantation parameters (dose, acceleration voltage) has been studied. Different profile shapes can be obtained. A combination of a high surface concentration and a rather flat profile in a surface layer is possible. Strong deviations from the normally expected Gaussian distribution are found after high dose implantation due to sputtering effects. However, if the sputter yield is experimentally determined, good prediction of the implanted dopant distribution is still possible. The peak concentration of high dose distributions is situated at or close to the surface. This surface peak concentration is obtained at a steady-state situation of concurrent sputtering and implantation of Fe. A maximum surface concentration with respect to Zr(Fe/Zr = 1.0) is achieved with the highest implantation energy used (110 keV) because the sputter yield is relatively low as compared with lower energies. After prolonged heat treatment in air (800°C, 24–60 hours) of the samples implanted with a high dose Fe, Fe203-rich surface layers are formed. Rutherford Backscattering Spectrometry (RBS) is used for the profile analyses in combination with Auger Electron Spectroscopy (AES).
Radar/ESM tracking of constant velocity target: comparison of batch (MLE) and EKF performance (2000)

In this paper we compare performance of batch (Maximum Likelihood Estimate MLE) and iterative (Extended Kalman Filter) techniques in the case of joint Radar/ESM tracking. Two issues are addressed. Tracking accuracy of both methods are evaluated by simulations and compared to the Cramer-Rao Lower Bound (CRLB). The radar scheduling is optimized in order to increase tracking accuracy.
Confidence measures in multiple pronunciations modeling for speaker verification (2004)

The paper investigates the use of multiple pronunciations modeling for user-customized password speaker verification (UCP-SV). The main characteristic of UCP-SV is that the system does not have any a priori knowledge about the password used by the speaker. Our aim is to exploit the information about how the speaker pronounces a password in the decision process. This information is extracted automatically using a speaker-independent speech recognizer. We investigate and compare several techniques. Some of them are based on the combination of confidence scores estimated by different models. In this context, we propose a new confidence measure that uses acoustic information extracted during speaker enrollment and based on a log likelihood ratio measure. These techniques show significant improvement (15.7% relative improvement in terms of equal error rate) compared to a UCP-SV baseline system where the speaker is modeled by only one model (corresponding to one utterance).
556. Comparative In Vitro Transduction Efficiency of AAV Vector Serotypes 1-9 in Different Cellular Models (2016)

Recombinant viral vectors can be useful tools for expressing transgenes in neuronal cells to study disease mechanisms and to test for therapeutic effect. Recombinant adeno-associated virus (AAV), generated from a nonpathogenic parvovirus, has become the most widely used vector in gene therapy applications in human. However, lack of suitable animal models that accurately reflect the human disease phenotype often stalls the development of treatment strategies. To overcome this problem, research is focused on generating induced pluripotent stem cells (iPSCs) from affected human subjects as in vitro models to explore the potential of gene augmentation therapy. An advantage of iPSCs is that these cells can be differentiated along a retinal cell lineage. In this study, we differentiated iPSCs into Neural Progenitor Cells (NPC) and compared the in vitro transduction efficiency of AAV serotypes 1-9. Differentiated NPCs were characterized by immunocytochemistry with the expression of NPCs specific markers (Sox2, Nestin, Pax6). Experiments were carried out using different AAVs serotypes containing the same transgene cassette: an enhanced green-fluorescent protein (eGFP) reporter gene driven by the cytomegalovirus immediate-early (CMV) promoter. At 24 to 48 hours post transduction, positive GFP expressing cells are examined by laser scanning in Typhoon. Relative GFP expression was evaluated by using the software ImageJ. In addition to the laser scanning method, flow cytometry was used to evaluate GFP expression in the cell population. Live cell imaging and flow cytometry evaluation revealed that AAV2 is the most efficient vector for in vitro transduction in NPC followed by AAV1, AAV3 and AAV6 while AAV4, AAV5, AAV7, AAV8 and AAV9 showed no transduction or extremely low transduction efficiency.
Biased Reduced Sampling: Detectability of an Attribute and Estimation of Prevalence (2005)

Abstract In surveilling a population, detection of systems with an attribute of interest and estimation of the prevalence of the attribute in the population are two main goals. Due to cost constraints, only a subset of all components of sampled systems may be fully tested. Biasing the sampling to increase the probability of choosing a component with an attribute of interest ameliorates the impact of reduced sampling. In this paper, we consider the impact of biased reduced sampling on detection and propose an approach for estimating the prevalence of the attribute in the population which properly accounts for the biasing. The proposed method is illustrated with a simulated example. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Behaviour of biomass particles in a large scale (2–4MWth) bubbling bed reactor (2015)

Biomass is regarded as an interesting fuel for energy-related processes owing to its renewable nature. However, the high volatile content of biomass adds a number of difficulties to the fuel conversion and process operation. In the context of fluidized bed reactors, several authors have observed that devolatilizing fuel particles tend to float on the surface of a gas-fluidized bed of finer solids. This behaviour, known as segregation, leads to undesired effects such as poor contact between volatiles and bed material. Previous investigations on segregation of gas-emitting particles in fluidized beds are conducted in small units and they are often operated at rather low gas velocities, typically between the minimum fluidization velocity (umf) and 2umf. Therefore, it is not known to what extent such results are of relevance for industrial scale units and for higher fluidization velocities that are commonly used in large bubbling beds. In this paper the behaviour of biomass particles in a large scale bubbling bed reactor is investigated. Tests were conducted at a wide range of fluidization velocities with three different bed materials of varying particle size and density. The fuel was wood pellets and the fluidization medium was steam, which makes the findings relevant for indirect gasification, chemical looping combustion (CLC) and bubbling bed combustion applications. The experiments were recorded by means of a digital video camera and the digital images were subsequently analysed qualitatively. The results show high level of segregation at fluidization velocity up to 3.5 umf. Beyond this point fuel mixing was significantly enhanced by increasing fluidization velocities. At the highest fluidization velocity tested (i.e. >8 umf), a maximum degree of mixing was achieved.
Impact of screening and follow‐up colonoscopy adenoma sensitivity on colorectal cancer screening outcomes in the CRC‐AIM microsimulation model (2020)

Assuming identical adenoma sensitivities for screening and follow-up/surveillance colonoscopies underestimate the potential benefits of stool-based screening strategies.