gebhart/patrepeval huggingface dataset:
Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (*#x2212;)-Indolactam V (1985)

Journal Article Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (*#x2212;)-Indolactam V Get access Kazuhiro Irie, Kazuhiro Irie Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobuyuki Hagiwara, Nobuyuki Hagiwara Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Koichi Koshimizu, Koichi Koshimizu Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan To whom inquiries should be addressed Search for other works by this author on: Oxford Academic Google Scholar Harukuni Tokuda, Harukuni Tokuda Department of Microbiology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Yohei Ito, Yohei Ito Department of Microbiology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Hayashi, Hideo Hayashi College of Agriculture, University of Osaka Prefecture, Sakai 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Sawao Murao Sawao Murao College of Agriculture, University of Osaka Prefecture, Sakai 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 49, Issue 5, 1 May 1985, Pages 1441–1446, https://doi.org/10.1080/00021369.1985.10866890 Published: 01 May 1985 Article history Received: 16 November 1984 Published: 01 May 1985
Kinetic and Equilibrium Analysis of Estradiol in Uterus: A Model of Binding-Site Distribution in Uterine Cells (1972)

Kinetic and equilibrium binding studies indicate that the process by which the complex of estradiol-binding protein is transferred to the cell nuclei is very rapid and is readily reversible in intact cells; that is, the cytosol and nuclear binding sites are in a rapidly reversible equilibrium. Binding of the hormone appears to shift this equilibrium such that a large percent of the filled binding sites become associated with the nuclear fraction. A model is presented to show that the quantity of filled nuclear binding sites present at any estradiol concentration can be determined strictly by the initial binding between the hormone and the cytosol binding sites.
Two C18 hydroxy-cyclohexenone fatty acids from mammalian epidermis: Potential relation to 12R-lipoxygenase and covalent binding of ceramides (2023)

A key requirement in forming the water permeability barrier in the mammalian epidermis is the oxidation of linoleate esterified in a skin-specific acylceramide by the sequential actions of 12R-lipoxygenase, epidermal lipoxygenase-3, and the epoxyalcohol dehydrogenase SDR9C7 (short-chain dehydrogenase-reductase family 7 member 9). By mechanisms that remain unclear, this oxidation pathway promotes the covalent binding of ceramides to protein, forming a critical structure of the epidermal barrier, the corneocyte lipid envelope. Here, we detected, in porcine, mouse, and human epidermis, two novel fatty acid derivatives formed by KOH treatment from precursors covalently bound to protein: a "polar" lipid chromatographing on normal-phase HPLC just before omega-hydroxy ceramide and a "less polar" lipid nearer the solvent front. Approximately 100 μg of the novel lipids were isolated from porcine epidermis, and the structures were established by UV-spectroscopy, LC-MS, GC-MS, and NMR. Each is a C18 fatty acid and hydroxy-cyclohexenone with the ring on carbons C<sub>9</sub>-C<sub>14</sub> in the polar lipid and C<sub>8</sub>-C<sub>13</sub> in the less polar lipid. Overnight culture of [<sup>14</sup>C]linoleic acid with whole mouse skin ex vivo led to recovery of the <sup>14</sup>C-labeled hydroxy-cyclohexenones. We deduce they are formed from covalently bound precursors during the KOH treatment used to release esterified lipids. KOH-induced intramolecular aldol reactions from a common precursor can account for their formation. Discovery of these hydroxy-cyclohexenones presents an opportunity for a reverse pathway analysis, namely to work back from these structures to identify their covalently bound precursors and relationship to the linoleate oxidation pathway.
P‐176: Innovative Trilayer Organic Light Emitting Transistor (OLET) Structure for Blue Emission (2016)

We report on a three‐layer organic light‐emitting transistor (3L‐OLET) comprising a novel set of semiconductors as transport layers, 2,7‐Dioctyl[1]benzothieno[3,2‐b][1]benzothiophene (C8‐BTBT) and 2,5‐bis[4‐(heptadecafluorooctyl)phenyl]thieno[3,2‐b]thiophene (N‐F2‐6). These materials, combined with an emissive layer of a 4,4'‐Bis(N‐carbazolyl)‐1,1'‐biphenyl (CBP) derivative, 4,4'‐bis(3,6‐dineopentyl‐9H‐carbazole‐9‐yl)‐1,'‐biphenyl (NP4‐CBP) and a new dye (BLUE1), have been used to obtain blue electroluminescent device.
Strategies for Screening for Colorectal Carcinoma (1989)

Four tests commonly used in screening strategies to detect colorectal cancer were examined from a cost-effectiveness perspective. Thirteen combinations of the tests were evaluated. Evaluating a positive fecal occult blood test with a double-contrast barium enema study, followed, if necessary, by colonoscopy, is the most cost-effective strategy for individuals at average risk. An alternative screening strategy for higher-risk individuals or for populations in which the frequency of adenomatous polyps is higher is to follow a positive fecal occult blood test directly with colonoscopy. Sensitivity analysis demonstrated that the superior cost-effectiveness of these two strategies compared with the other 11 modeled strategies is almost independent for reasonable alterations in test cost and for the sensitivities and specificities of the procedures. The major contributing factor to the diagnostic cost is the frequency of adenomatous polyps. The major contributing factor to the marginal cost per year of extended life is the frequency of cancer.
Fluorescent Imaging for In Situ Measurement of Drug Target Engagement and Cell Signaling Pathways (2020)

Successful targeted cancer treatment continues to elude modern medicine and its many therapeutic strategies. Herein, we propose a fluorescent imaging technique to measure drug localization and subsequent cell signaling perturbations on a single cell basis
ScopeSense: An 8.5-month sport, nutrition, and lifestyle lifelogging dataset (2023)

Nowadays, most people have a smartphone that can tracktheir everyday activities. Furthermore, a significant number of people wear advanced smartwatches to track several vital biomarkers in addition to activity data. However, it is still unclear how these data can actually be used to improve certain aspects of people’s lives. One of the key challenges is that the collected data is often massive and unstructured.Therefore, a link to other important information (e.g., when, what, and how much food was consumed) is required. It is widely believed that such detailed and structured longitudinal data about a person is essential to model and provide personalized and precise guidance. Despite the strong belief of researchers about the power of such a data-driven approach, respective datasets have been difficult to collect. In this study, we present a unique dataset from two individuals performing a structured data collection over eight and a half months. In addition to the sensor data, we collected their nutrition, training, and well-being data.The availability of nutrition data with many other important objectives and subjective longitudinal data streams may facilitate research related to food for a healthy lifestyle. Thus, we present a sport, nutrition, and lifestyle logging dataset called ScopeSense from two individuals and discuss its potential use. The dataset is fully open for researchers, and we consider this study as a potential starting point for developing methods to collect and create knowledge for a larger cohort of people.
[PPARs and heart diseases]. (2005)

After it has been reported that activation of PPARalpha or PPARgamma suppresses production of proinflammatory cytokines, medical interest in PPARs have grown and a huge research effort has been concentrated. Synthetic antidiabetic thiazolidinediones (TZDs) and natural prostaglandin D2 (PGD2) metabolite, 15d-PGJ2, are well known as ligands for PPARgamma. Hyperlipidemic drugs (fibrates) are synthetic PPARalpha ligands. Recent studies suggest that ligands of PPAR not only regulate glucose and lipid metabolism but also have pleiotropic effects on many tissues and cell types. Ligands of PPARs may become therapeutic agents useful in the prevention of cardiovascular diseases beyond their effects on glucose and lipid metabolism. This review will focus on the latest developments in the PPARs field and the roles of PPAR-dependent pathway in cardiovascular diseases.
Practical diets for captive monotremes and marsupials. (1981)

The aim with feeding all captive wild animals is to group them according to dietary habits, then as far as possible to substitute their natural diet with compounded diets already commercially available. To provide a diverse range of captive animals each with its natural diet . is economically not feasible. Some feed companies' in the U.S. specialise in the formulation and production of zoo diets. Some of these diets are. . very specialised, such as Hallwood's Flamingo Diet (Hume 1977). This compounded diet contains both natural and synthetic sources of pigmentation (shrimp meal and Flaminol respectively) to generate and maintain vivid feather colouration. In Australia the number of zoos, both public and private, is so small that no feed company can market a complete range of specialised zoo diets. This means that authorities housing monotremes and marsupials in 'general have to try to use feeds formulated for domestic species. Often a combination .of a domestic formulation and natural food items is the .best compromise. In this paper the wide range of dietary habits of Australian marsupials and monotremes is considered in relation to current feeding practices in some zoos. .
The Raytheon-SORDS trimodal imager (2009)

The Raytheon Trimodal Imager (TMI) uses coded aperture and Compton imaging technologies as well as the nonimaging shadow technology to locate an SNM or radiological threat in the presence of background. The coded aperture imaging is useful for locating and identifying radiological threats as these threats generally emit lower energy gammas whereas the Compton imaging is useful for SNM threats as in addition to low energy gammas which can be shielded, SNM threats emit higher energy gammas as well. The shadow imaging technology utilizes the structure of the instrument and its vehicle as shadow masks for the individual detectors which shadow changes as the vehicle moves through the environment. Before a radioactive source comes into the fields of view of the imagers it will appear as a shadow cast on the individual detectors themselves. This gives the operator advanced notice that the instrument is approaching something that is radiological and on which side of the vehicle it is located. The two nuclear images will be fused into a combined nuclear image along with isotope ID. This combined image will be further fused with a real-time image of the locale where the vehicle is passing. A satellite image of the locale will also be made available. This instrument is being developed for the Standoff Radiation Detection System (SORDS) program being conducted by Domestic Nuclear Detection Office (DNDO) of the Department of Homeland Security (DHS).
Effect of L-10B-p-boronophenylalanine-fructose and the boron neutron capture reaction on mouse brain dopaminergic neurons. (1995)

Radiation damage to the dopamine tracts caused by enriched L-10B-p-boronophenylalanine (L-10BPA)-fructose and the boron neutron capture reaction was investigated using the mouse model. Following various treatments with L-10BPA and neutron irradiation of the head, the brain was perfusion fixed and removed; 50-microns frozen sections were cut. Dopaminergic neurons were visualized using immunohistochemistry for tyrosine hydroxylase. The administration of L-10BPA had no permanent effect on dopaminergic tracts. Neutron capture therapy with L-10BPA caused a reduction in tyrosine hydroxylase immunohistochemical activity within 4 h of irradiation, but by 48 h, this reduction reversed. No damage was observed at 120 h postirradiation.
Mechanical characterization of iPP injection molded samples on multiple length scale (2019)

The mechanical characterization at different length scales, from macro to nanometer scale, represents a very intriguing possibility to analyze the effect of developed morphologies on the properties of a molded polymer material. In this work, isotactic polypropylene molded samples, obtained with different processing conditions, have been mechanically characterized on different lengths scales. Dynamic Mechanical Analysis (DMA), micro Indentation and HarmoniX Atomic Force Microscopy (AFM) tests have been carried out to characterize injection molding iPP samples from millimeter to nanometer scale. Optical microscopy and AFM analyses show a complex morphology composed ? by a thin layer of globular elements at the sample surface, spherulites in the sample core and fibrils in the intermediate zone. The well organized and oriented structures, i.e. the fibrils, are characterized by higher values of mechanical modulus, whereas the globules, less organized structures, show very small elastic modulus values, close to the characteristic values observed in quiescent amorphous phase. Intermediate values of elastic modulus are observed in the sample core, where well developed spherulitic structures are characterized by both higher crystallinity and lower level of orientation. The elastic modulus obtained by HarmoniX AFM technique are in good agreement with the values obtained by Indentation tests in the same sample positions, confirming the complementarity of these techniques for a complete multi-scale sample characterization. The cross section modulus distributions nicely compare with DMA results.
Identification of a retrovirus in human breast cancer (2005)

548 Background: Breast cancer (BC) in mice is caused by mouse mammary tumor virus (MMTV). We have reported that 38% of BC in American women contain envelope gene sequences, 95% to 99% homologous to the env gene of MMTV implying the presence of a human mammary tumor virus (HMTV) (Cancer Res 55, 5173; 1995). Env positivity is high in regions with high incidence of BC (Western Europe, North Africa, the Americas, Australia) and low in low regions (Asia, Asia Minor) (Clin Cancer Res 10, 5647; 2004). Methods: Polymerase chain reaction (PCR), reverse transcriptase PCR (RT-PCR), and nucleotide sequencing were performed by standard Methods: Env positive breast cancer cells were co-cultured for five days through a micropore barrier with normal breast or peripheral blood mononuclear cells (PBMC). Results: A complete 9.9 kb proviral structure has been identified, 95% homologous to MMTV. Unique differences from MMTV are systematically found in the long terminal repeat (LTR) gene of the HMTV. Normal tissues of the same patient do not contain sequences, thereby excluding endogenous sequences and genetic inheritance as mechanisms of transmission. In six of twelve experiments viral sequences were transferred to allogeneic breast cells and in four of six to allogeneic PBMC as detected by specific monoclonal antibody staining and by PCR. Conclusions: HMTV is an infectious agent, horizontally acquired, that can be transmitted from BC cells in vitro. These data establish that a substantial proportion of human BC is associated with a viral agent, HMTV, closely similar to MMTV, which is known to cause mammary tumors in mice. The correlation of HMTV with human BC incidence is consistent with considerations of causality. No significant financial relationships to disclose.
U.S. Military Casualty Statistics: Operation New Dawn, Operation Iraqi Freedom, and Operation Enduring Freedom (2013)

This report presents statistics regarding U.S. military casualties in the active Operation Enduring Freedom (OEF, Afghanistan), as well as operations that have ended: Operation New Dawn (OND, Iraq) and Operation Iraqi Freedom (OIF, Iraq). This report includes statistics on post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), amputations, evacuations, and the demographics of casualties.
Modification of lignans by Trametes hirsuta laccase (2009)

Oxidative polymerization of two isolated lignans, secoisolariciresinol, and secoisolariciresinol diglucoside, as well as the lignan macromolecule, by a high redox potential Trametes hirsuta laccase was studied with different analytical methods. The reactivity of laccase with the different compounds was studied by an oxygen consumption measurement. The polymerization of laccase-treated lignans was evidenced by size exclusion chromatography, reversed phase - high performance liquid chromatography, and matrix-assisted laser desorption/ionisation - time of flight mass spectrometry. The data showed that the selected substrates could be oxidised by laccase. Secoisolariciresinol and secoisolariciresinol diglucoside were polymerized by laccase to a similar extent. The lignan macromolecule reacted to a lesser extent. Polymerization of the macromolecule proceeded mainly via its secoisolariciresinol diglucoside moieties. Furthermore, it was shown that ferulic acid can be linked to polymerized secoisolariciresinol via decarboxylation by laccase. This investigation showed that lignans can be enzymatically modified by Trametes hirsuta laccase.
Active learning for online bayesian matrix factorization (2012)

The problem of large-scale online matrix completion is addressed via a Bayesian approach. The proposed method learns a factor analysis (FA) model for large matrices, based on a small number of observed matrix elements, and leverages the statistical model to actively select which new matrix entries/observations would be most informative if they could be acquired, to improve the model; the model inference and active learning are performed in an online setting. In the context of online learning, a greedy, fast and provably near-optimal algorithm is employed to sequentially maximize the mutual information between past and future observations, taking advantage of submodularity properties. Additionally, a simpler procedure, which directly uses the posterior parameters learned by the Bayesian approach, is shown to achieve slightly lower estimation quality, with far less computational effort. Inference is performed using a computationally efficient online variational Bayes (VB) procedure. Competitive results are obtained in a very large collaborative filtering problem, namely the Yahoo! Music ratings dataset.
A Generic Modeling Approach for Automotive Power Net Consumers (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The integration of safety-critical and major power-consuming electrical systems presents a challenge for the development of future automotive electrical networks. Both reliability and performance must be enhanced in order to guarantee the power supply to essential electrical consumers at a sufficient degree of power quality. Often, in order to cope with these requirements, merely an upgrade of the existing wiring harness design is used, resulting in additional complexity, weight, and cost [&lt;span class="xref"&gt;3&lt;/span&gt;].&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;A characterization of the wiring harness and its electrical consumers facilitates a systematic optimization approach aimed at designing new automotive power networks [&lt;span class="xref"&gt;1&lt;/span&gt;, &lt;span class="xref"&gt;5&lt;/span&gt;]. Measurement and analysis methods to characterise the thermal behaviour of the wiring harness have been presented and discussed in a previous paper [&lt;span class="xref"&gt;4&lt;/span&gt;]&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper presents and compares two methods aimed at modeling the electrical behavior of consumers at various voltages and temperatures. The first, conventional method relies on physics-based, analytical models. The second method is based on a generic representation of non-linear dynamic behavior using a common model frame for various electrical consumers. A dedicated parameterization strategy for the data-driven models is developed. The two modeling approaches are compared in terms of representation, flexibility and generalization capabilities. The models obtained are integrated into a modular and scalable HiL test platform used to characterize and test automotive electrical power nets in an early phase of the development process.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The methodology and tools used, as well as the results obtained, are presented and discussed in this paper.&lt;/div&gt;&lt;/div&gt;
Optimization via Gene Expression Algorithms (2005)

The extreme diversity of life forms on our planet is a testament to the many ways in which millions of different species have adapted to the huge number of biological niches that are available ranging, as they do, over extremes in temperature and pressure in air, land, and water. Viewed in an abstracted formulation, we may consider evolutionary adaptation of species within a biological niche to be a robust search and optimization mechanism (Fogel, 1994), the phenotype changing over time so that the species survives in its competitive environment. Under the Darwinian view, evolutionary processes are involved with reproduction, mutation, competition, and selection. The bioinspired strategies of genetic algorithms and evolutionary optimization, in general, strive to capture these biologically robust search mechanisms by formulating mathematical models that search function domains using algorithmic procedures that mimic some of the evolutionary processes of the cell, for example, mutation, and crossover. Before discussing these procedures, let us go over a superficial but quick review of the main biological events in the cell.
Is Image Memorability Prediction Solved? (2019)

This paper deals with the prediction of the memorability of a given image. We start by proposing an algorithm that reaches human-level performance on the LaMem dataset - the only large scale benchmark for memorability prediction. The suggested algorithm is based on three observations we make regarding convolutional neural networks (CNNs) that affect memorability prediction. Having reached human-level performance we were humbled, and asked ourselves whether indeed we have resolved memorability prediction - and answered this question in the negative. We studied a few factors and made some recommendations that should be taken into account when designing the next benchmark.
A MIMO system with backward compatibility for OFDM based WLANs (2003)

Orthogonal frequency-division multiplexing (OFDM) has been selected as the basis for the new IEEE 802.11a standard for high-speed wireless local area networks (WLANs). We consider doubling the data rate of the IEEE 802.11a system by using a multi-input multi-output (MIMO) system with two transmit and two receive antennas. We propose a preamble design for this MIMO system that is backward compatible with its single-input single-output (SISO) counterpart as specified by the IEEE 802.11a standard. Based on this preamble design, we devise a sequential method for the estimation of the carrier frequency offset (CFO), symbol timing, and channel response. We also provide a simple soft-detector to obtain the soft-information for the Viterbi decoder. Both the sequential parameter estimation method and the soft-detector are ideally suited for real-time implementations. The effectiveness of our methods is demonstrated via numerical examples.