gebhart/patrepeval huggingface dataset:
Leakage Assessment of Pressure-Exchange Wave Rotors (2008)

Control of leakage within waw rotors is recognized as a key requirement for efficient operation.Previous studies suggest that experimentally observed perfonnance degradation is substantially due to flow leakage.This work presents a leakage model for predicting leakage-attributed performance degradation of four-port pressureexchange '":ave roto.rsmore accurately than previous single-cavity leakage models.The methodology comprehensively considers the leakage paths of the entire device.It combines a wave-rotor quasi-one-dimensional computational fluid dynamics prediction code, experimentally validated for internal gas dynamics with the generalized How-circuit-modeling capability of a leakage-How network solver.The computational fluid dynamics program and the network solver step through a series of iterations by sharing common leakage information.~pplication to a well-instrumented wave-rotor rig is brieHy summarized, providing important guidance for the Irnpro~ement of le~kage and performance.The new approach is anticipated to be useful in enhancing the design, operation, and efficiency of a broad class of wave rotors by better understanding leakage and hence designing sealing features to control leakage Hows.
CONVERSION OF HIGH EXPLOSIVES (1997)

The disposal of high explosives was not a problem prior to German reunification. Large quantities (300,000 tons) of old and substandard munitions were acquired when the former German Democratic Republic (GDR) was reunited with the Federal Republic of Germany (FRG). This paper evaluates processes available for the conversion of high explosives, and concludes that an affordable and readily available method for the destruction of high explosives from old ordnance is controlled burning.
Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants (2010)

The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells initiates a complex series of biochemical events that result in the release of inflammatory mediators. The essential role of the protein tyrosine kinase Syk has been appreciated for some time, and newer results have defined the mechanism of its activation. The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways.
Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism (2007)

The alpha/beta interferon (IFN-alpha/beta) response is critical for host protection against disseminated replication of many viruses, primarily due to the transcriptional upregulation of genes encoding antiviral proteins. Previously, we determined that infection of mice with Sindbis virus (SB) could be converted from asymptomatic to rapidly fatal by elimination of this response (K. D. Ryman et al., J. Virol. 74:3366-3378, 2000). Probing of the specific antiviral proteins important for IFN-mediated control of virus replication indicated that the double-stranded RNA-dependent protein kinase, PKR, exerted some early antiviral effects prior to IFN-alpha/beta signaling; however, the ability of IFN-alpha/beta to inhibit SB and protect mice from clinical disease was essentially undiminished in the absence of PKR, RNase L, and Mx proteins (K. D. Ryman et al., Viral Immunol. 15:53-76, 2002). One characteristic of the PKR/RNase L/Mx-independent antiviral effect was a blockage of viral protein accumulation early after infection (K. D. Ryman et al., J. Virol. 79:1487-1499, 2005). We show here that IFN-alpha/beta priming induces a PKR-independent activity that inhibits m(7)G cap-dependent translation at a step after association of cap-binding factors and the small ribosome subunit but before formation of the 80S ribosome. Furthermore, the activity targets mRNAs that enter across the cytoplasmic membrane, but nucleus-transcribed RNAs are relatively unaffected. Therefore, this IFN-alpha/beta-induced antiviral activity represents a mechanism through which IFN-alpha/beta-exposed cells are defended against viruses that enter the cytoplasm, while preserving essential host activities, including the expression of antiviral and stress-responsive genes.
Cytokine system as potential target for antipsoriatic therapy (1994)

Cytokines are produced by a variety of cells and have numerous of overlapping activities. There is increasing evidence that cytokines play a crucial role in the pathogenesis of psoriasis and of other dermatologic diseases. This review summarizes current knowledge as to how the altered cytokine network is involved in the accumulation of inflammatory cells in lesional skin, and how the cytokines are involved in epidermal hyperproliferation. The actions of the most important therapeutic compounds, such as corticosteroids, dithranol, cyclosporine, retinoids, vitamin D3 analogues and ultraviolet radiation, on the cytokine system are also discussed. Consideration is given as to how the effects on the production of cytokines and/or cytokine receptors contribute to their therapeutic action.
SPECIES-SPECIFIC SEQUENCE VARIATION OF PORCINE ISLET AMYLOID POLYPEPTIDE REDUCES ITS AMYLOIDOGENICITY AND MAY CONTRIBUTE TO IMPROVED FUNCTION AND SURVIVAL OF PIG ISLET XENOGRAFTS (2008)

Introduction: Long-term success of human islet transplants has been limited. Beta cell mass and function in transplanted islets progressively decline over time, resembling the progressive loss of insulin secretion in type2 diabetes. Transplanted islets, like those in type 2 diabetes, are subject to apoptotic beta cell death and the formation of toxic aggregates of the betacell peptide islet amyloid polypeptide (IAPP). Interestingly, porcine islets consistently maintain long-term normoglycemia when transplanted into immune-deficient, diabetic mice. We hypothesized that transplanted pig islets may not be subject to amyloid formation and amyloid-induced cell death, and that this may contribute to the success of porcine islet grafts. Methods &amp; Results: Sequencing of porcine IAPP (pIAPP) from neonatal pig islet (NPI)-extracted RNA confirmed notabledifferences from human IAPP (hIAPP), including a proline substitution within the known amyloidogenic region and a glutamine-for-lysine at the N-terminalcleavage site of porcine proIAPP. Fibril formation was assessed by electron miscroscopy (EM) and Thioflavin T fluorescence. While synthetic hIAPP fibrillized within minutes, pIAPP required 6 weeks to form fibrils detectableby EM. Small peptide fragments of pIAPP failed to aggregate. By Thioflavin T fluorescence assay, hIAPP (40 µM) had an average lag time of 1 h and a 1,000-fold increase in fluorescence by 2 h while pIAPP showed little increase in fluorescence after 20 h. Small peptide fragments of pIAPP also failed to aggregate. hIAPP was significantly more toxic to INS-1 cells than pIAPP (20-200 µM), asassessed by TUNEL (16 h) and Alamar blue (24 h). We also failed to detect amyloid in any (0/9) NPI transplanted into streptozotocin diabetic murine recipients, while human islets had extensive amyloid deposition by 8 weeks post-transplant, associated with graft failure. Conclusion: Porcine IAPP, unlike human IAPP, is only weakly amyloidogenic and cytotoxic. We speculate that decreased fibrillogenicity of porcine compared to human IAPP may underlie the apparent enhanced survival andfunction of pig islet xenografts. KJP is supported by aChild &amp; Family – Rx &amp; D &amp; CIHR – UBC MD PhD Studentship and a MichaelSmith Foundation for Health Research Junior Trainee Award.
Secondary Breakdown Meter (1970)

The paper describes an instrument developed for the study of secondary breakdown (SB) characteristics of semiconductor devices. The characteristic parameters of SB phenomenon can be obtained with the help of this instrument along with a CRO. The Voltage and current levels associated with the SB phenomenon are obtained through the V-I characteristic of the device under breakdown and the delay characteristics are obtained from the voltage waveform. This instrument can be used to study the SB characteristics of diodes and transistors with reverse base drive.
A lognormal approximation for the gray level statistics in ultrasound images (2002)

The gray level statistics of an image are important for the design of image processing algorithms. In this paper, a lognormal distribution is proposed as a practical approximation for the gray level distribution of ultrasound images. This provides a relatively simple model for describing the image, and enables techniques originally developed for a Gaussian probability distribution to be used. We compute various moments of the gray level distribution and show that the model predicts power laws between specific combinations of moments. These predictions, as well as two additional expressions resulting from the model, are validated using ultrasound images of various ovarian masses.
Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance (2013)

We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemia. We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism in rats through a loss-of-function approach using a specific antisense oligonucleotide (ASO) to decrease expression predominantly in liver and adipose tissue. Pyruvate carboxylase ASO reduced plasma glucose concentrations and the rate of endogenous glucose production in vivo. Interestingly, pyruvate carboxylase ASO also reduced adiposity, plasma lipid concentrations, and hepatic steatosis in high fat-fed rats and improved hepatic insulin sensitivity. Pyruvate carboxylase ASO had similar effects in Zucker Diabetic Fatty rats. Pyruvate carboxylase ASO did not alter de novo fatty acid synthesis, lipolysis, or hepatocyte fatty acid oxidation. In contrast, the lipid phenotype was attributed to a decrease in hepatic and adipose glycerol synthesis, which is important for fatty acid esterification when dietary fat is in excess. Tissue-specific inhibition of pyruvate carboxylase is a potential therapeutic approach for nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes.
PHASE TRANSITION AND DIAMOND SYNTHESIS OF CARBON NANOTUBES UNDER HIGH PRESSURE AND HIGH TEMPERATURE (2000)

The phase transition of carbon nanotubes under high pressure and high temperature has been investigated by transmission electron microscope and scanning electron microscope.It is found that the nanotubes are unstable under high pressure and high temperature.When being annealed at the temperature range of 770℃ and 950℃ under 5.5GPa,the carbon nanotubes will transform into carbon onions.The diamond is synthesized under the conditions of 1000℃ and 5.0GPa.The mechanism of the phase transition of carbon nanotubes is well discussed.
Robustesse au Doppler du filtre de Wiener pour un radar OFDM (2022)

International audience
Wagner surface replacement arthroplasty of the hip. Analysis of fourteen failures in forty-one hips. (1981)

Wagner resurfacing arthroplasty of the hip was performed on forty-one hips in forty patients from 1977 to 1979. Results were analyzed with particular attention to prosthetic failures, which occurred in fourteen hips. Loosening of the femoral component occurred in five hips; loosening of both the femoral and the acetabular component, in two hips; loosening of the acetabular component, in two hips; loosening of the acetabular component, in two hips; avascular necrosis of the femoral head (with no concomitant femoral-component loosening), in two hips; and femoral neck fracture, in three hips. Time to failure averaged eighteen months (range, three months to two and one-half years). The over-all failure rate of 34 per cent is considered unacceptably high and therefore I do not recommend the Wagner arthroplasty for routine use. Factors tht may be responsible for the increased failure rate include a high susceptibility to avascular necrosis of the femoral head, the younger age of patients in whom this operation is performed, and the biomechanical design properties of the prosthesis.
Interleukin‐1α and Interleukin‐1 β in Preterm and Term Human Parturition (1992)

Interleukin-1 (IL-1) has been implicated in the mechanism of human parturition in the setting of infection. The purpose of this study was to determine the effect of labor (term and preterm) and microbial invasion of the amniotic cavity on amniotic fluid (AF) concentrations IL-1 alpha and IL-1 beta. AF was retrieved by transabdominal amniocentesis from the following groups of women: midtrimester genetic amniocentesis (16 to 18 wk) (N = 15), preterm labor with intact membranes (21 to 36 wk) with or without infection (N = 72), preterm premature rupture of membranes (PROM) (N = 88), and term not in labor or in active labor with or without infection (N = 58). AF was cultured for aerobic and anaerobic bacteria as well as Mycoplasmas. IL-1 was measured with a commercially available immunoassay validated for AF (sensitivity: IL-1 alpha, 157 pg/ml; IL-1 beta, 50 pg/ml). All women at midtrimester had undetectable AF IL-1 alpha and IL-1 beta. Among women in preterm labor with positive AF cultures, IL-1 alpha and IL-1 beta were detectable in the AF in 86.6% (13/15) and 100% (15/15), respectively. In contrast, all women with negative AF cultures without labor (N = 36) had undetectable AF IL-1 alpha concentrations and 52.7% (19/36) had undetectable AF IL-1 beta concentrations. Histopathological chorioamnionitis was present in 92.8% (13/14) of patients who had positive AF cultures and detectable IL-1 in the AF. IL-1 was significantly higher in patients with preterm PROM, labor, and positive AF cultures than in the other subgroups of patients with preterm PROM.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 19201: Clinical Impact of Cardiac Regenerative Therapy With Autologous Skeletal Stem Cell Sheet Implantation on Treating Severe Heart Failure (2015)

Background: Transplantation of autologous somatic tissue-derived cells into the heart has been shown to yield functional recovery of the failing heart via “paracrine effects” that enhance the native regenerative process. We have introduced skeletal stem cell (SSC) sheet methods for treating severe heart failure (HF), in which scaffold-free cell-sheets are attached on the epicardial surface to maximize the paracrine effects. We herein report feasibility, safety and efficacy of SSC sheet transplantation for treating advanced HF. Methods: This study enrolled 27 patients (mean age, 51±15 years, DCM in 15 patients and ICM in 12 patients) with chronic advanced HF despite optimum treatments. Scaffold-free cell-sheets containing SSC (average: 3.5±1.9х108 cells) was transplanted over the left ventricular (LV) free wall via the left thoracotomy. Average follow-up was 2.5 (0.6-5.1) years. Results: All patients discharged from the hospital without procedure-related complications. Re-In-hospital treatment for congestive HF was required in 8 patients, who we defined as non-responder (Group N: n=8), while the other patients who were free from in-hospital cardiac treatments were defined as responder (Group R: n=19). The Group R exhibited decreased NYHA functional class (2.8±0.6 to 1.6±1.1 p&lt;0.05) and increased 6-minute walk test (444±110 to 499±114m p&lt;0.05) at 6 months, while these values maintained until the latest follow-up. Echocardiographically, LV systolic and diastolic diameters significantly decreased and ejection fraction significantly increased. In addition, both LV end-systolic and diastolic wall stress, assessed by cardiac CT scanning, significantly decreased (systolic: 377±76 to 317±88, diastolic: 116±98 to 51±32 kdynes/cm2, p&lt;0.05 respectively) in the Group R. Multivariate analysis showed that preoperative duration of HF was a single independent risk factor for Group N with its hazard ratio 1.8 (p&lt;0.05). Three-year freedom from cardiac death was 92%, while that from recurrence of HF was 70%. Conclusions: SSC sheet transplantation was feasible and safe in advanced HF patients. Functional recovery, including reduced LV wall stress, was gained in the selected patients, who received this treatment in early stage of advanced HF.
Dissecting the functional role of different isoforms of the L-type Ca2+ channel (2004)

There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene so that the pharmacological sensitivity of the gene product is altered. An example of such an approach shows how the abolition of the sensitivity of an L-type Ca(2+) channel isoform to dihydropyridines allows the investigation of the physiological role of these channels in different tissues .
Polymer and Organic Nonvolatile Memory Devices (2010)

Organic molecules and semiconductors have been proposed as active part of a large variety of nonvolatile memory devices, including resistors, diodes and transistors. In this review, we focus on electrically reprogrammable nonvolatile memories. We classify several possible devices according to their operation principle and critically review the role of the π-conjugated materials in the device operation. We propose specifications for applications for organic nonvolatile memory and review the state of the art with respect to these target specifications. Conclusions are drawn regarding further work on materials and device architectures.
High performance polysilicon NEMS fabricated at low temperature with UV laser annealing (2016)

In this paper, we present for the first time poly-Silicon nanowire (poly-Si NW) based NEMS resonators fabricated at very low temperature (300°C max) and recrystallized with a 308nm excimer laser for low cost co-integrated mass sensors on CMOS. Poly-Si NEMS performances have been systematically compared to crystalline silicon (c-Si) NEMS and most important resonator's figure of merit have been extracted. Within an excellent fabrication yield, the stability measurements of poly-Si NEMS lead to a mass resolution detection in air down to 190 zg (×10-21g).
Quantum confinement effect for efficient hole injection in MONOS-type nonvolatile memory-the role of ultrathin i-Si/P<sup>+</sup> poly-Si stacked gate structure fabricated by laser spike annealing (2007)

A novel hole injection method is proposed for fast and damage-free erasing operation in MONOS-type nonvolatile memory. Ultrathin intrinsic Si (i-Si) layer at the interface between gate dielectrics and P+ poly-Si gate produces quantum confinement level of hole. This lowers effective band offset, thus, significantly increases hole tunneling probability from the gate electrode. By applying the novel gate structure to MONOS cells, we successfully demonstrate memory operation with 100 times faster erase speed and larger memory window than conventional gate.
A Family of Dual Resonant Switched-Capacitor Converter With Passive Regenerative Snubber (2019)

In this article, a step-down switched-capacitor converter (SCC) and a step-up SCC with an integrated passive regenerative snubber (PRS) are proposed based on the Cuk dual resonance core (DRC). The members of the DRC converter family overcome the barrier for SCCs to achieve continuous output voltage regulation. One remaining challenge is the turn-off spikes and oscillations during the switch turn-off transient that cause voltage stress and power loss to the transistor and diode. The proposed integrated PRS eliminates voltage spikes and oscillations across the transistor and diode during the turn-off process. Moreover, zero voltage switching (ZVS) turn-on for the clamped mosfet, zero current switching (ZCS) turn-on for the other mosfet and ZCS turn-off for all diodes are achieved. A comprehensive analysis of the operation principle, conversion ratio curves, component stress, and regenerative power of the proposed converters with regenerative snubbers is given. Furthermore, a performance comparison between the proposed snubber configuration and two conventional methods is given. A 50 V/99.25 V step-up converter prototype of 125 W has demonstrated a peak efficiency of 98.4%. The analysis is verified by both simulation and experiments.
Supplementary Table 2 from Differential Gene Expression Analysis Reveals Activation of Growth Promoting Signaling Pathways by Tenascin-C (2023)

Supplementary Table 2 from Differential Gene Expression Analysis Reveals Activation of Growth Promoting Signaling Pathways by Tenascin-C
Reversible Insertion von Platin in Münzmetall‐Halogen‐Bindungen (2012)

M & M: Durch die reversible Insertion eines Platinkomplexes in Münzmetall-Halogen-Bindungen wurde eine Reihe von allein aus Metallen bestehenden Lewis-Paaren erhalten, die also nicht durch zusätzliche Brücken stabilisiert sind. In den Lewis-Paaren koordiniert das Lewis-basische Platin(0)-Fragment an kationische Kupfer-, Silber- und Gold-Lewis-Säuren (siehe Schema; M=Cu, Ag, Au; Cy=Cyclohexyl). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The efficacy and safety of recombinant tissue plasminogen activator infusion in acute myocardial infarction. (1989)

rt-PA is safe and effective in the treatment of acute myocardial infarction in the early stage. Coronary arteriography can be safely delayed until three hours postinfusion, and the achieved reperfusion rate is up to 83%.
Effect of cepharanthin and hyperthermia on the intracellular accumulation of adriamycin in the NIH3T3 cell lines transfected with oncogenes accompanied with pSV2neo vector. (1996)

The influence of several oncogenes on drug resistance has recently been show by transfection studies. Therefore, we investigated the influence of transfection on adriamycin (ADR) in cell line transfected with several oncogenes accompanied with pSV2neo vector. There were differences in both the intracellular accumulation of ADR and its sensitivity among the transfectants used in this study. There was a good correlation with the intracellular accumulation of ADR and its sensitivity (r = 0.76, P = 0.002). Further, there were no differences in the ADR efflux among the ras-family transfectants. Therefore, the changes in ADR sensitivity may be due to changes in ADR influx. On the other hand, the ADR accumulation showed an increase of 1.14-1.29 fold by the treatment of 10 micrograms/ml CEP. Moreover, the ADR accumulation showed an increase of 1.29-3.11 fold by hyperthermia at 42 degrees C. There was no significant difference in the ADR accumulation at 42 degrees C among the transfectants, suggesting that the influence on the ADR accumulation may be counteracted by hypethermia at 42 degrees C.
The Asymptotic Behavior of Undiscounted Value Iteration in Markov Decision Problems (1977)

This paper considers undiscounted Markov Decision Problems. For the general multichain case, we obtain necessary and sufficient conditions which guarantee that the maximal total expected reward for a planning horizon of n epochs minus n times the long run average expected reward has a finite limit as n → ∞ for each initial state and each final reward vector. In addition, we obtain a characterization of the chain and periodicity structure of the set of one-step and J-step maximal gain policies. Finally, we discuss the asymptotic properties of the undiscounted value-iteration method.
Mental health, loneliness and life satisfaction in the dynamic context of COVID-19 pandemic policies and healthcare burden: A two-year cohort study in the Netherlands (2022)

This pre-print examines well-being, loneliness and life satisfaction over the course of the COVID-19 pandemic in the Netherlands