gebhart/patrepeval huggingface dataset:
Secreted Factors from Human Vestibular Schwannomas Can Cause (2015)

Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle. Ninety-five percent of people with VS present with sensorineural hearing loss (SNHL); the mechanism of this SNHL is currently unknown. To establish the first model to study the role of VS-secreted factors in causing SNHL, murine cochlear explant cultures were treated with human tumour secretions from thirteen different unilateral, sporadic VSs of subjects demonstrating varied degrees of ipsilateral SNHL. The extent of cochlear explant damage due to secretion application roughly correlated with the subjects’ degree of SNHL. Secretions from tumours associated with most substantial SNHL resulted in most significant hair cell loss and neuronal fibre disorganization. Secretions from VSs associated with good hearing or from healthy human nerves led to either no effect or solely fibre disorganization. Our results are the first to demonstrate that secreted factors from VSs can lead to cochlear damage. Further, we identified tumour necrosis factor alpha (TNF α) as an ototoxic molecule and fibroblast growth factor 2 (FGF2) as an otoprotective molecule in VS secretions. Antibody-mediated TNFα neutralization in VS secretions partially prevented hair cell loss due to the secretions. Taken together, we have identified a new mechanism responsible for SNHL due to VSs. Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle and the fourth most common intracranial neoplasms. Although VSs arise from the vestibular nerves, 95% of patients with VS present with sensorineural hearing loss (SNHL). The underlying pathophysiological mechanisms of this SNHL are cur rently unknown 1 .
Ultra-Performance Liquid Chromatography for the Simultaneous Quantification of Rutin and Chlorogenic Acid in Leaves ofRibesL. Species by Conventional and Chemometric Calibration Approaches (2015)

A new ultra-performance liquid chromatography (UPLC) using conventional and chemometric calibrations was improved for the simultaneous estimation of chlorogenic acid (CA) and rutin (RUT) in leaves of Ribes L. species (R. rubrum, R. biebersteinii, R. nigrum, R. uva-crispa, R. alpinum, R. orientale, R. multiflorum and R. anatolica). The UPLC separation for CA and RUT in samples were performed on a Waters UPLC BEH phenyl column (100 mm × 1.0 mm i.d., 1.7 μm) and mobile phase consisting of acetonitrile and 0.1 M formic acid buffer, pH = 3.77 (15:85, v/v) containing 1.0 mL triethylamine in 1,000 mL mobile phase. Multi-wavelength UPLC chromatograms of CA and RUT in calibration and plant samples were obtained by the photodiode array (PDA) detection at the wavelength set from 290 to 360 nm with the interval of Δλ = 10 nm. Conventional UPLC-single and chemometric calibrations were subjected to the analysis of the related compounds. By using UPLC data, conventional and chemometric calibrations in the linear concentration range between 2.5 and 40.0 μg/mL for all compounds were applied for the simultaneous quantitative analysis of CA and RUT in plant samples of seven different Ribes species.
Design of Modular Converters; Survey and Introduction to Generic Approaches (2009)

This paper presents a new approach based on converter networks using elementary cells (ec). It deals with the beginning of research and development carried out on the design of the "ec", the random command and the magnetic coupling among the elementary cells. This paper introduces at first the recent works carried out on interleaved "ec" and power electronics converters (cvs) into networks: from basic interleaving approaches, trying to minimize filter sizes up to highly coupled solutions trying to optimize sizes but also current and voltage levels. In the next sections of the paper, the modular approach will be presented. The paper presents a study showing how a random mode control is used to simplify the implementation of a generic "ec" into any network. Evaluating the output voltage filtering criteria, we compare classical synchronous interleaved and random mode controls. Then, the paper focuses on the design and the characterization of the elementary cell and especially on its active part. The last part of the paper focuses on magnetic coupling for converter coupling and filtering. Experimental results underline the importance of coupling among elementary cells and inside the corresponding "cvs" and an analytical study of magnetic coupling is presented. An 2n-windings transformer formed of n identical three-winding transformers is used to connect the "ec" among them. The aims of these studies are to improve electrical management of modular "cvs" network without any constraints on the modularity and the genericity of the approach.
The Immunogenicity of a Conformationally Restricted Peptide Mimetic of Meningococcal Lipooligosaccharide (2005)

Life-threatening meningitis and septicaemia caused by Neisseria meningitidis are a public health priority, and their prevention by vaccination is a major objective. Meningococcal capsular polysaccharide-based vaccines are effective against the major invasive serogroups, except for serogroup B, the capsule of which mimics human polysaccharides and is poorly immunogenic. An alternative vaccine candidate that has the potential to offer cross-protection against antigenically diverse meningococci is the lipooligosaccharide (LOS). The structurally constrained peptide mimetic, C22, of a bactericidal antibody epitope within LOS was previously shown to elicit cross-reactive antibodies to meningococcal LOS when complexed to NeutrAvidintrade mark as a carrier protein. The immunogenicity of this antigen in H-2(d) (BALB/c) and H-2(k) (C3H/HeN) haplotype mice was further investigated. Anti-LOS immunoglobulin G (IgG) antibody titres increased with the vaccine dose and correlated with the anti-C22 peptide antibody titres in both haplotypes. Antigen-stimulated Th1/Th2 cytokine secretion by splenocytes and antibody isotypes indicated a Th2-type immune response with IgG1 antibodies and a low titre of IgG2b. There was no serum bactericidal activity observed against the meningococcus.
Quenching of intrinsic fluorescence of yeast cytochrome c peroxidase by covalently- and noncovalently-bound quenchers (1993)

The intrinsic steady-state fluorescence of the heme enzyme cytochrome c peroxidase (CCP) has been characterized as a probe of its structure in solution. The fluorescence is dominated by tryptophan emission, which has a quantum yield of 7% relative to the tryptophan standard N-acetyltryptophanamide, and an emission maximum at 324 nm indicative of a relatively hydrophobic environment for the fluorescent residues. These fluorescence properties are consistent with the known structure of CCP; six of the seven tryptophan residues are well within quenching distance for efficient Förster energy transfer to the heme, so that the intrinsic fluorescence arises largely from Trp101 which is approximately 26 A from the heme and partially buried. Quenching studies using Cs+, I-, and acrylamide are also consistent with this picture, since the charged species are poor quenchers, but acrylamide, which can penetrate the protein matrix, is a more effective quencher. The intrinsic fluorescence of two CCP derivatives with the quencher pentaammineruthenium(III) covalently attached to His6 and His60 has also been characterized. The His60 derivative, shown by X-ray analysis to be essentially structurally identical to native CCP, is 17% less fluorescent than native CCP, consistent with the quenching expected from distance calculations and the assignment of Trp101 as the major fluorescent center. The observed quenching of 38% in the second derivative is close to that predicted for ruthenation of His6 assuming that Trp101 is the major fluorophore. The fluorescence of compound I of CCP is also reported. This species, which has a ferryl (FeIV = O) heme and a protein radical purportedly on Trp191, exhibits 9% higher fluorescence than native CCP.(ABSTRACT TRUNCATED AT 250 WORDS)
Amelioration of the abnormal phenotype of a new L1 syndrome mouse mutation with L1 mimetics (2021)

L1 syndrome is a rare developmental disorder characterized by hydrocephalus of varying severity, intellectual deficits, spasticity of the legs, and adducted thumbs. Therapy is limited to symptomatic relief. Numerous gene mutations in the L1 cell adhesion molecule (L1CAM, hereafter abbreviated L1) were identified in L1 syndrome patients, and those affecting the extracellular domain of this transmembrane type 1 glycoprotein show the most severe phenotypes. Previously analyzed rodent models of the L1 syndrome focused on L1-deficient animals or mouse mutants with abrogated cell surface expression of L1, making it difficult to test L1 function-triggering mimetic compounds with potential therapeutic value. To overcome this impasse, we generated a novel L1 syndrome mouse with a mutation of aspartic acid at position 201 in the extracellular part of L1 (p.D201N, hereafter termed L1-201) that displays a cell surface-exposed L1 accessible to the L1 mimetics. Behavioral assessment revealed an increased neurological deficit score and increased locomotor activity in male L1-201 mice carrying the mutation on the X-chromosome. Histological analyses of L1-201 mice showed features of the L1 syndrome, including enlarged ventricles and reduced size of the corpus callosum. Expression levels of L1-201 protein as well as extent of cell surface biotinylation and immunofluorescence labelling of cultured cerebellar neurons were normal. Importantly, treatment of these cultures with the L1 mimetic compounds duloxetine, crotamiton, and trimebutine rescued impaired cell migration and survival as well as neuritogenesis. Altogether, the novel L1 syndrome mouse model provides a first experimental proof-of-principle for the potential therapeutic value of L1 mimetic compounds.
Thermophysical Properties of Lithium Bromide + 1, 2-Propanediol Aqueous Solutions— Solubility, Density and Viscosity (2012)

The solubilities, densities and viscosities of lithium bromide (LiBr) + 1, 2-propanediol (HO-CH2-CHOH-CH3) aqueous solution (mass ratio of LiBr/HO-CH2-CHOH-CH3 = 3.5, 4.5 and 5.5) were measured in the mass fraction range from 0.30 to 0.75. Solubility measurements were performed by the visual method in the temperature range of (271.15 to 345.15) K. The density measurements were made using an automated vibrating tube density meter, and the viscosity measurements were carried out with an automated falling-ball viscometer in the temperature range of (293.15 to 363.15) K. The density and viscosity data were correlated with appropriate regression equations as a function of the mass fraction and temperature. The maximum average absolute deviations (AAD) between experimental and correlated data were 0.08% and 1.51% for densities and viscosities, respectively.
The Synthesis of p-Toluenesulfonyl-L-isoleucyl-L-glutaminyl- L-asparagine and Related Peptides1 (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of p-Toluenesulfonyl-L-isoleucyl-L-glutaminyl- L-asparagine and Related Peptides1Panayotis G. Katsoyannis and Vincent du VigneaudCite this: J. Am. Chem. Soc. 1954, 76, 12, 3113–3115Publication Date (Print):June 1, 1954Publication History Published online1 May 2002Published inissue 1 June 1954https://pubs.acs.org/doi/10.1021/ja01641a003https://doi.org/10.1021/ja01641a003research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Colorectal Surgery: Short-Term Prophylaxis with Clindamycin Plus Aztreonam or Gentamicin (1991)

A randomized study was conducted to compare the effectiveness of aztreonam plus clindamycin with that of gentamicin plus clindamycin for prophylaxis of infection following colorectal surgery. A total of 138 patients undergoing elective colorectal surgery were randomized to treatment with clindamycin (600 mg) plus either aztreonam (1 g) or gentamicin (80 mg) 30 minutes before and 8 and 16 hours after surgery. The study included 122 patients (88.4%) with colorectal carcinoma. Samples from the abdominal cavity and from the subcutaneous tissues were taken for bacteriologic study. All samples from the abdominal cavity yielded microorganisms; both aerobic and anaerobic bacteria were isolated. Wound infections occurred in eight patients (12.1%) in the aztreonam group and in 12 patients (16.7%) in the gentamicin group. Escherichia coli, Bacteroides species, enterococci, and staphylococci were isolated most frequently from wounds and were often isolated from bacteriologic samples from the abdominal cavity of the same patients. The incidence of septic complications reflected the extent of nutritional and immunologic impairment. No significant differences were found between groups in the rate of urinary tract or lower respiratory tract infections. Aztreonam/clindamycin appears to be a valid alternative to gentamicin/clindamycin for the prophylaxis of infections following colorectal surgery.
Catalytic Enantioselective Reductive Cyclization of Acetylenic Aldehydes via Hydrogenation (2007)

The reductive cyclization of acetylenic aldehydes is accomplished via rhodium-catalyzed asymmetric hydrogenation. This process provides access to a wide variety of cyclic allylic alcohols in good yields and with high levels of asymmetric induction.
Book Review: An Ever More Complex Union: the Regional Variable as a Missing Link in the EU Constitution?, edited by Roberto Toniatti, Francesco Palermo, Marco Dani. (Baden-Baden: Nomos, 2004) (2006)

View Book Review: <i>An Ever More Complex Union: the Regional Variable as a Missing Link in the EU Constitution?</i>, edited by Roberto Toniatti, Francesco Palermo, Marco Dani. (Baden-Baden: Nomos, 2004) by Andrew Evans - Common Market Law Review
Polar Step-Driven Metal Nucleation and Growth: The Ag/ZnO(1010) Case (2020)

The morphology, epitaxy, band alignment, and optical response of silver nanoparticles on ZnO(101̅0) have been analyzed by microscopy, electron diffraction, photoemission and differential reflectivity. At 700 K, clusters tend to nucleate and grow exclusively along [010]-oriented polar steps and corners and not on flat terraces or nonpolar [001] steps. This preference leads to a specific epitaxy Ag[11̅0](111) ∥ ZnO[010](101̅0) with a large lattice mismatch along the dense row of the metal. The experiments have been rationalized through ab initio simulations. A much lower adsorption energy is obtained for the O-terminated steps with a charge transfer from silver to oxygen that corroborates the variation of ionization energy observed in photoemission and the presence of cationic silver. This anisotropy of growth reverberates in the plasmonic response of the metallic particles. The growth and epitaxy of metals on polar (0001) and nonpolar (101̅0) orientations of ZnO are discussed in terms of surface/step polarity compensation in the light of the present findings.
Computational modelling study of yttria-stabilized zirconia (2010)

Interatomic potential and quantum mechanical simulation techniques have been applied to both the bulk and surfaces of yttrium-stabilized cubic zirconia (YSZ) with special reference to its role in partial oxidation reaction at high temperature. The stabilities of pure ZrO2 phases and surfaces have been examined. The bulk structures of low pressure phases are reproduced with the observed order of stability: monoclinic &gt; tetragonal &gt; cubic zirconia. The relative stability of plane cubic ZrO2 surfaces is predicted to be (111)c &gt; (110)c &gt; (100)c &gt; (310)c. In addition, the stability of topological surfaces is found to be reduced with the coordination number of Zr ions at the topological sites in the order: plane &gt; step &gt; kink &gt; corner.&#13;\nThe dispersion of defects in YSZ systems has been studied, considering both the dopant content and surface segregation. In the bulk, the yttrium dopants tend to form a pair with two yttrium atoms close to each other and preferentially occupying the 1st or 2nd nearest neighbour (NN) sites to the compensating oxygen vacancy. At the surface, yttrium segregates to the top layers (up to 4-5 Å) of the dominant (111) surface of YSZ. The composition of the outermost surface of YSZ is predicted to be independent of Y bulk concentration and reach a maximum Y/Zr ratio of 1:1.&#13;\nIn relation to catalytic oxidation, the interaction between oxygen molecules and the (111) surfaces of pure c-ZrO2 and YSZ have been investigated using quantum-mechanical DFT-GGA methods. The adsorption states of oxygen and the pathways for dissociation have been indentified on the plane and stepped (111) surfaces. In general, the creation of oxygen vacancies by yttrium doping provides an active site for oxygen adsorption. In addition, the low-coordinated Zr cations on the YSZ surfaces can attract strongly reduced oxygen species and the most stable adsorption state of oxygen is adopted to achieve a higher bond saturation of the neighbouring Zr site.
Multi-use solar energy intensifier-thermal energy storage system performance (1981)

The 37.9 m/sup 2/, SEI-TES system provided the energy equivalents of 0.92 and 1.0 kWh/D* m/sup 2/ during field tests for in-storage, grain drying and ventilation air pre-heating, respectively. Preliminary tests indicate that the SEI-TES system can also be used for water heating.
The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding (2002)

The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced PAK activation. We have also demonstrated that expression of active Rac enhances the ability of plexin-B1 to interact with Sema4D. Active Rac stimulates the localization of plexin-B1 to the cell surface. The enhancement in Sema4D binding depends on the ability of Rac to bind plexin-B1. These observations support a model where signaling between Rac and plexin-B1 is bidirectional; Rac modulates plexin-B1 activity and plexin-B1 modulates Rac function.
Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS (2005)

Oxidized carbon nanotubes are tested as a matrix for analysis of small molecules by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Compared with nonoxidized carbon nanotubes, oxidized carbon nanotubes facilitate sample preparation because of their higher solubility in water. The matrix layer of oxidized carbon nanotubes is much more homogeneous and compact than that of nonoxidized carbon nanotubes. The efficiency of desorption/ionization for analytes and the reproducibility of peak intensities within and between sample spots are greatly enhanced on the surface of oxidized carbon nanotubes. The advantage of the oxidized carbon nanotubes in comparison with alpha-cyano-4-hydroxycinnamic acid (CCA) and carbon nanotubes is demonstrated by MALDI-TOF-MS analysis of an amino acid mixture. The matrix is successfully used for analysis of synthetic hydroxypropyl beta-cyclodextrin, suggesting a great potential for monitoring reactions and for product quality control. Reliable quantitative analysis of jatrorrhizine and palmatine with a wide linear range (1-100 ng/mL) and good reproducibility of relative peak areas (RSD less than 10%) is achieved using this matrix. Concentrations of jatrorrhizine (8.65 mg/mL) and palmatine (10.4 mg/mL) in an extract of Coptis chinensis Franch are determined simultaneously using the matrix and a standard addition method.
Primeiro relato de superbrotamento da mandioca em Santa Catarina, Brasil (2015)

Resumo: Plantas de mandioca doentes, com sintomas de amarelecimento, redução de tamanho e superbrotamento foram verificadas no litoral sul catarinense. O objetivo deste trabalho foi identificar o agente causal da doença. Quatro amostras de plantas doentes foram analisadas por nested PCR em laboratório, confirmando a presença de um fitoplasma. A incidência da doença foi constatada de forma localizada em uma lavoura comercial e recomendou-se a eliminação das plantas doentes como método de controle. Este trabalho é o primeiro relato do superbrotamento da mandioca no estado de Santa Catarina.
Methane Emissions Abatement by Multi-Ion-Exchanged Zeolite A Prepared from Both Commercial-Grade Zeolite and Coal Fly Ash (2008)

The performance of multimetal-(Cu, Cr, Zn, Ni, and Co)-ion-exchanged zeolite A prepared from both a commercial-grade sample and one produced from coal fly ash in methane emissions abatement was evaluated in this study. The ion-exchange process was used to load the metal ions in zeolite A samples. The methane conversion efficiency by the samples was studied under various parameters including the amount of metal loading (7.3-19.4 wt%), reaction temperature (25-500 degrees C), space velocity (8400-41 900 h(-1)), and methane concentration (0.5-3.2 vol %). At 500 degrees C, the original commercial-grade zeolite A catalyzed 3% of the methane only, whereas the addition of different percentages of metals in the sample enhanced the methane conversion efficiency by 40-85%. Greater methane conversion was observed by increasing the percentage of metals added to the zeolite even though the BET surface area of the zeolite consequently decreased. Higher percentage methane conversion over the multi-ion-exchanged samples was observed at lower space velocities indicating the importance of the mass diffusion of reactants and products in the zeolite. Compared to the multi-ion-exchanged zeolite A prepared from the commercial-grade zeolite, the one produced from coal fly ash demonstrated similar performances in methane emissions abatement, showing the potential use of this low cost recycled material in gaseous pollutant treatment.
Un chanoine angevin constructeur, Pierre Bonhomme le Jeune († 1446) (2004)

Hélène Millet et al.