gebhart/patrepeval huggingface dataset:
Headache associated with moyamoya disease: a case story and literature review (2009)

Headache associated with moyamoya disease (HAMD) is common in moyamoya disease. However, the characteristics and classification of HAMD are largely unknown. We present a case of a 39-year-old woman with HAMD. To characterize and classify the features of this syndrome, the patient was asked to complete a 4-month diagnostic headache diary. There was a total of 15 ictal days. All episodes were without aura. The headache was more commonly pressing (10/15), mild to moderate in severity (14/15), unchanged by physical activity (11/15), and associated with photophobia (10/15). The International Headache Society Classification was utilized to determine that eight episodes met criteria for probable migraine without aura, while seven episodes met criteria for probable frequent episodic tension-type headache. We identified four other case reports of HAMD with partial descriptions of the characteristics. When combined with our patient, the median age was 34 years old (range 6–49, SD 16). Four were female, while the patient with cluster headache was male. The median time from headache onset to diagnosis with moyamoya disease was 9.5 months (range 0–192, SD 88.0). Headaches were described as migraine with aura in two of five cases, hemiplegic migraine in one of five, and cluster headache in one of five. The highest intensity was described as severe in three of three cases, in which headache intensity was reported. Meanwhile, nausea, vomiting, and photophobia were present in two of three cases, where these features were reported, while nausea without vomiting was seen in one of three cases. In all five cases, patients had other neurological symptoms, such as paresis, seizures, visual disturbances, dysarthria, allodynia, ptosis, and unilateral restless leg syndrome. In conclusion, HAMD can present as migraine without aura. It can be the first presenting symptom of moyamoya disease. The headache features are not diagnostic; hence, early neurovascular imaging should be considered in patients with new onset, refractory migraine-like headache, especially in the setting of other neurological symptoms to exclude underlying moyamoya disease. Further reports using headache diaries are needed to better characterize HAMD as well as to determine whether headache with tension-type features is also part of this condition.
Hammer and rifle: the militarization of the Soviet Union, 1926-1933 (2001)

From 1926 to 1933, a vast transformation swept through the Soviet Union, a massive militarization of society that was as powerful and far-reaching as the Revolution itself. This work chronicles this transformation and shows why it is so central to our understanding of Stalin's emergence and consolidation of power. While collectivization dramatically altered rural Russia and Stalin ruthlessly secured his control over the state apparatus, a military-industrial revolution remade the USSR into an immensely powerful war machine. As Stone reveals, the militarization of the Soviet economy - marked by a rapidly expanding defence industry, increasing centralized control and growing military influence over economic policies - was an essential element in Stalin's strong-armed revolution from above. Spurred by the Bolshevik's unrelenting suspicions of other nations, the Soviet state embraced rearmament and military preparedness as its guarantee for national survival. Soviet military thinkers, Stone shows, pushed for a ruthlessly centralized economy - one requiring total integration of state and society - as the necessary means for achieving victory in future wars. The result was an ever upwardly spiralling defence budget and increasing military domination of civilian society. Stone demonstrates how this domination emerged, evolved and entrenched itself. But he also suggests that this military-industrial revolution, theoretically designed to protect the Soviet Union's national security, instead nearly destroyed it at the beginning of World War II. The rigid and inflexible economy that resulted ultimately undermined the Soviet state itself, destroying from within much of what it had tried to defend. Based on the use of new archival sources, Stone's study also provides a cautionary tale about civil-military relations in an increasingly dangerous world.
Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive ??? compulsive disorder: an open trial (1999)

Inositol, an isomer of glucose and precursor in the phosphatidylinositol cycle, may be effective in a number of psychiatric disorders, including obsessive-compulsive disorder (OCD). There is little data, however, on inositol as an augmenting agent of serotonin reuptake inhibitors (SRIs) in treatment-refractory patients. Ten OCD patients who had failed to respond to current and previous trials of serotonin reuptake inhibitors participated in open-label trial of inositol (18 gm/day) [corrected] augmentation for 6 weeks. Symptoms were rated at 2-weekly intervals using the Yale-Brown Obsessive-Compulsive Scale, the Montgomery-Asberg Depression Rating Scale, and the Clinical Global Impressions (CGI) Scale. The majority of patients (n = 7) did not respond to treatment with inositol augmentation on the CGI improvement item. However, a small number of patients (n = 3) did report a clinically significant response on the CGI improvement item. OCD patients who fail to respond to a number of trials of SRIs may be a particularly treatment-refractory group of subjects. Unfortunately, inositol augmentation of a SRI did not lead to significant improvement in the majority of such cases. Nevertheless, further research on the mechanism of inositol efficacy in some patients with anxiety and mood disorders is warranted.
Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101, 606-27 alone and in combination with rt-PA in a thromboembolic stroke model in rats (2003)

The data in this study suggested that postischemia treatment with CP-101,606-27 is neuroprotective in the current stroke model; however, the authors also note that although rt-PA may offer modest protection when used alone, combination with CP-101,606-27 did not appear to enhance its effects.
The Effect of Ultrapolish on a Transonic Axial Rotor (2005)

Back-to-back testing has been done using NASA fan rotor 67 in the Glenn Research Center W8 Axial Compressor Test Facility. The rotor was baseline tested with a normal industrial RMS surface finish of 0.5–0.6 μm (20–24 microinches) at 60, 80 and 100% of design speed. At design speed the tip relative Mach number was 1.38. The blades were then removed from the facility and ultrapolished to a surface finish of 0.125 μm (5 microinch) or less and retested. At 100% speed near the design point, the ultrapolished blades showed approximately 0.3–0.5% increase in adiabatic efficiency. The difference was greater near maximum flow. Due to increased relative measurement error at 60 and 80% speed, the performance difference between the normal and ultrapolished blades was indeterminate at these speeds.
Vanadium, niobium and tantalum (2008)

This report summarizes the literature from 2007 pertaining to the chemistry of the group 5 elements. Novel coordination and organometallic compounds are included, along with selected applications in the areas of catalysis and bioinorganic/medicinal chemistry.
State Estimation for Wastewater Treatment Processes (2006)

This chapter contains sections titled: Introduction Preliminaries Observers for Linear Systems Observers for Mass-balance-based Systems Interval Observers Conclusions References
A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model (2020)

The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda<sup>®</sup>) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG<sub>4</sub>/κ isotype designed to directly block the interaction between PD-1 and its ligands, PD-L1 and PD-L2. The current work was focused on developing a mouse T-Dependent Antibody Response (TDAR) model using a murinized rat anti-mouse PD-1 antibody (muDX400; a rodent surrogate for pembrolizumab) to evaluate the potential impact of treatment with a PD-1 inhibitor on immune responses to an antigen challenge (e.g. HBsAg in Hepatitis B vaccine). Despite the lower binding affinity and T<sub>1/2</sub> compared to pembrolizumab, ligand blocking data indicated muDX400 had appropriate pharmacological activity and demonstrated efficacy in mouse tumor models, thus was suitable for pharmacodynamic and vaccination studies in mice. In a vaccination study in which mice were concomitantly administered muDX400 and the Hepatitis B vaccine, muDX400 was well-tolerated and did not result in any immune-mediated adverse effects. The treatment with muDX400 was associated with a shift in the ratio between naive and memory cells in both CD4<sup>+</sup> and CD8<sup>+</sup> T-lymphocytes in the spleen but did not affect anti-HBsAg antibody response profile. The mouse TDAR model using the Hepatitis B vaccine and the surrogate anti-PD1 monoclonal antibody was a useful tool in the evaluation of the potential immune-mediated effects of pembrolizumab following vaccination and appears to be a suitable alternative for the nonhuman primate TDAR models utilized for other checkpoint inhibitors.
Comparative performance evaluation of GM-PHD filter in clutter (2009)

Random Finite Sets (RFS) offer a diligent formalism for tracking an unknown number of targets with multiple sensors. The Probability Hypothesis Density (PHD) filter, and its Gaussian Mixture (GM) and Sequential Monte Carlo (SMC) implementations, provide tractable Bayesian Filtering methods that propagate the first order moment of the RFS probability density. A feature of the PHD filters is that they do not require association to complete their correction step. This, we believe, should constitute a significant advantage, especially in scenarios of high false alarm rates and track intersections, which can easily compromise most observer-predictor methods that must perform association to carry out their correction step. To test this hypothesis, we compare the performance of the GM-PHD to the traditional Kalman (KF) and SMC filters for visual tracking of multiple targets in moderate to heavy false alarm rate scenarios. Our tracking and association performance results seem to support this hypothesis.
Conformationally defined adrenergic agents. 15. Conformationally restricted and conformationally defined tyramine analogs as inhibitors of phenylethanolamine N-methyltransferase (1989)

In a search for a selective inhibitor for the epinephrine synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28), phenolic 2-aminotetralins (12-15 as conformationally restricted analogues of tyramine) and phenolic benzobicyclo[3.2.1]octylamines (22-24 as conformationally defined analogues of tyramine) were used to gain information about the binding interactions of the catecholic hydroxyl groups in the natural substrate norepinephrine at the active site of PNMT. In addition, these analogues provided information about the effects of conformational flexibility on active-site interaction of the aminoethyl side chain in phenolic phenylethylamines that may aid in learning the manner in which norepinephrine binds at the active site of PNMT. Analogues 22-24 were synthesized by a nine-step sequence, in which a Friedel-Crafts type intramolecular cyclization was the key step in the construction of the benzobicyclo[3.2.1]octane skeleton. p-Tyramine (10, Ki = 294 microM) was more potent than phenylethylamine (1, Ki = 854 microM) but m-tyramine (9, Ki = 1250 microM) was less potent than phenylethylamine as an inhibitor of PNMT. Similarly, in the conformationally restricted and conformationally defined tyramine analogues (12-15 and 22-24, respectively), the analogues with the p-tyramine moiety (14, Ki = 4.7 microM; 23, Ki = 111 microM) bind to PNMT better than do the corresponding unsubstituted compounds (16, Ki = 6.8 microM; 25, Ki = 206 microM) while the analogues with the m-tyramine moiety (13, 15, 22, and 24) have a lower binding affinity than do 16 and 25. The greatly enhanced activity of the phenolic 2-aminotetralins (12-15) compared with m- and p-tyramine (9 and 10, respectively) is likely due to the restriction of the side-chain conformation. The conformationally defined analogues 22-24 were less active than the conformationally restricted ones, 12-15, although the low-energy half-chair conformation of 2-aminotetralin is defined in 22-24. The reduced activity of 22-24 compared with the activity of 12-15 is probably due to the steric hindrance from the extra bridging atoms in binding to PNMT. The interaction of the p-hydroxyl group of the tyramine moiety may involve hydrogen bonding since the corresponding methyl ethers show a greatly reduced affinity for the active site of PNMT (Ki = 34 and 389 microM for methoxy analogues 28 and 35, compared to Ki = 4.7 and 111 microM for the corresponding phenolic analogues 14 and 23).
Small Molecule Modulators of Transcription (2006)

Signal transduction cascades ultimately trigger transcriptional programs that are executed by transcription factors interacting with coactivator or corepressor proteins in large multi-protein complexes. Despite the difficulties associated with discovering and verifying potent antagonists (or agonists) of protein-protein interaction events, several small molecules have been identified within the last few years that modulate transcription by directly interacting with transcriptional proteins. Some of these small molecules display surprising selectivity and some even show efficacy in vivo. This review summarizes the current status in this developing field to illustrate the emerging opportunities in the chemical biology of transcription.
View synthesis prediction using adaptive depth quantization for 3D video coding (2013)

Advanced multiview video systems are able to generate intermediate viewpoints of a 3D scene. In addition to the texture content, corresponding depth is associated with each viewpoint. To improve the coding efficiency of such content, view synthesis prediction can be used to further reduce inter-view redundancy in addition to traditional disparity compensated prediction. However, the predictor generated from the view synthesis process is affected by several factors, including signal properties of the texture, the accuracy of the depth and complexity of the scene, as well as coding errors in both the texture and depth. This paper presents an analysis of view synthesis prediction performance considering these factors. Based on this analysis, an adaptive depth quantization scheme is proposed to improve the depth coding, leading to better view synthesis prediction and overall coding efficiency gains. The proposed scheme is able to achieve an average bit rate savings of 0.9% on the coded and synthesized video with a maximum gain of up to 11.7% on the dependent views in the context of an HEVC-based codec.
Nucleotide sequence of the 5.8S ribosomal RNA gene ofLentinulaedodes (1992)

Journal Article Nucleotide sequence of the 5.8S ribosomal RNA gene of Lentinula edodes Get access H.S. Kwan, H.S. Kwan Search for other works by this author on: Oxford Academic PubMed Google Scholar K.M. Pang, K.M. Pang Search for other works by this author on: Oxford Academic PubMed Google Scholar S.W. Chiu, S.W. Chiu Search for other works by this author on: Oxford Academic PubMed Google Scholar S.C. Cheng S.C. Cheng 1Department of Applied Biology and Chemical TechnologyHong Kong Polytechnic, Kowloon, Hong Kong Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 3, 11 February 1992, Page 610, https://doi.org/10.1093/nar/20.3.610 Published: 11 February 1992 Article history Received: 20 December 1991 Published: 11 February 1992
Stereoselective Total Synthesis of (−)-Depudecin (2015)

The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing two epoxides conjugated through a trans-disubstituted olefin, its total synthesis was efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts, allowing for the construction of the oxirane rings in an efficient and stereoselective fashion.
IR-SPECTRUM STUDIES OF EFFECTS OF NITRIC ACID TREATMENT ON CARBOXYL GROUPS ON MULTI-WALL CARBON NANOTUBES (1999)

Multi-wall carbon nanotubes were treated in boiling nitric acid and the effect of treatment time on carboxyl groups on the surface of multi-wall carbon nanotubes was studied by IR-spectrum.The results indicate that boiling nitric acid can create carboxyl groups on the surface of carbon nanotubes,and the amount of carboxyl groups increases with treatment time .The suitable treatment time should be less than 2 h.
Characteristics of bacterial cellulose membranes produced by Gluconacetobacter hansenii PJK in fed-batch cultivation (2008)

Bacterial cellulose (BC) has recently gained much attention in the research realm for its potential applications in various fields, especially; their biomedical and cosmoceutical features are of considerable interest. These applications require BC in the film form, which can be produced only under static cultivation. The amount of BC produced in static conditions is lower compared to agitated/shaking culture conditions. In the present study, BC membranes were produced by G. hansenii PJK under static culture conditions in jar fermenters using chemically-defined medium in fed-batch cultivation. Fed-batch enhanced the BC production compared to the batch cultivation. The produced BC membranes were characterized using various techniques including field-emission scanning electron microscopy (FE-SEM), X-ray diffractometry (XRD), gel permeation chromatography (GPC), CP/MAS (13C-NMR), and Fourier Transform InfraredSpectroscopy (FTIR). The physico-mechanical characteristics of BC membranes wereinvestigated by measuring its water holding capacity, water release rate and mechanicalstrength (stress-strain and elasticity). These results of production and characterization ofBC membranes obtained in fed-batch cultivation will be presented in comparison to batchcultivation.
Mitigating wakeup effect and improving endurance of ferroelectric HfO2-ZrO2 thin films by careful La-doping (2019)

The crystalline structure and electrical response of La-doped HfO2-ZrO2 thin films of which processing temperature did not exceed 400 °C were examined, where the La-doping concentration was varied from zero to ≈2 mol. %. The film structure and associated properties were found to vary sensitively with the minute variation in the La-concentration, where the ferroelectric response at low La-concentration (&amp;lt;≈1 mol. %) gradually became antiferroelectric-like for La-concentration &amp;gt;≈1 mol. %, which was accompanied by a significant increase in dielectric permittivity. La-doping was found to be very effective in inhibiting the monoclinic phase formation and in decreasing the leakage current. Notably, the high coercive field, which was one of the most significant problems in this material system, could be decreased by ∼35% at the most promising La-concentration of 0.7 mol. %. As a result, a highly promising field cycling endurance up to 1011 cycles could be secured while maintaining a high remnant polarization value (≥25 μC/cm2). This is one of the best results in this field of the authors' knowledge.
A power quality prediction system (2000)

This paper describes two hardware prototypes and estimation schemes for determining the parameters of a simple, physically based, point-of-use electric utility model using transient measurements. Parameters of the utility model are estimated using data collected by the prototypes. Frequency-dependent effects observed in previous work in this area are modeled. Performance of the techniques given is demonstrated by comparison of measured and predicted line voltage distortion during current transients created by several loads.
Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels (2015)

α-Cell dysfunction contributes to hyperglycemia in type 2 diabetes and is characterized by inappropriately increased basal and postprandial glucagon levels (1). The regulation of glucagon secretion remains poorly understood. Glucagon-like peptide 1 (GLP-1), a gut-derived hormone with glucose-dependent insulinotropic effects, has been shown, albeit mostly in short-term studies, to reduce fasting and postprandial glucagon levels. Thus, the glucagonostatic effect of GLP-1 receptor agonists has been considered as one of the key mechanisms by which they improve glycemia (2). However, in a recent 48-week study with the GLP-1 receptor agonist liraglutide, a paradoxical postprandial increase in glucagon levels was observed (3). This study challenged our understanding of the effects of GLP-1 receptor agonists on glucagon.

We assessed the effects of 3-year treatment with the GLP-1 receptor agonist exenatide (EXE) versus insulin glargine (GLAR) on fasting and postprandial glucagon levels. Details of the study design were reported previously (4). In short, 36 …
Object-oriented software testing-some research and development (2002)

It is widely accepted that the OO paradigm will significantly increase software reusability, extendibility, interoperability, and reliability. This is also true for high assurance systems engineering, provided that the systems are tested adequately. Software testing is an important software quality assurance activity to ensure that the benefits of OO programming will be realized. OO software testing has to deal with new problems introduced by the powerful new features of OO languages. The objective of the article is to review some of the existing research in OO software testing, in particular, the research at the University of Texas at Arlington.
[Effects of human recombinant basic Fibroblast Growth factor on endothelial wound healing in organ culture of human cornea]. (1996)

The effects of human recombinant bFGF has been evaluated on 9 paired human donor corneas (age 75 +/- 8 years), preserved in organ culture medium.The endothelium of corneas were mechanically wounded (area of 7.53 +/- 2.05 mm2) and placed in culture medium during 14 days. For each pair, one cornea was tested with bFGF (50 ng/ml), delivered in two times (day 0, day 7), according to the stockage of the bFGF on the basal membranes (low affinity receptor), while the ipsilateral cornea served as control. Endothelium was assessed by trypan staining at day 0, day 7, and day 14. At this term of fourteenth day, alizarine red and trypan blue staining permitted morphometric data.The bFGF factor increases significantly cell density in the wound area (p < 0.05), and in the transitional area (p < 0.01), compared to the control group. In the transitional area, cells depletion was only 15% (392 +/- 55 cells/mm2) in the treated group compared to the 28% (716 +/- 0.1 cells/mm2) in the untreated group. In the wound area, the mean cell area was averaged 2581 microns2 in the control group and 2161 microns2 in the bFGF treated group (p < 0.05); in the transitional area the mean cell size was 549 microns2, and 479 microns2 in the control and the bFGF treated group (p < 0.05) respectively. The bFGF group do not affect the shape factor.This assay demonstrates that human bFGF greatly facilitates wound closure in endothelium of human cornea. The cellular migration from the transitional zone seems the dominant healing mechanism.