gebhart/patrepeval huggingface dataset:
Ethylene oligomerisation chromium catalysts with unsymmetrical PCNP ligands (2021)

Chromium(iii) complexes of chelating diphosphines, with PNP or PCNCP backbones, are excellent catalysts for ethylene tetra- and/or trimerisations. A missing link within this ligand series are unsymmetric chelating diphosphines based on a PCNP scaffold. New bidentate PCNP ligands of the type Ph<sub>2</sub>PCH<sub>2</sub>N(R)PPh<sub>2</sub> (R = 1-naphthyl or 5-quinoline groups, 2a-d) have been synthesised and shown to be extremely effective ligands for ethylene tri-/tetramerisations. Three representative tetracarbonyl Cr<sup>0</sup> complexes bearing a single PN(R)P (5), PCN(R)P (6), or PCN(R)CP (7) diphosphine (R = 1-naphthyl) have been prepared from Cr(CO)<sub>4</sub>(η<sup>4</sup>-nbd) (nbd = norbornadiene). Furthermore we report a single crystal X-ray diffraction study of these compounds and discuss their structural parameters.
Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models (2020)

Falcarindiol (FaDOH) is a cytotoxic and anti-inflammatory polyacetylenic oxylipin found in food plants of the carrot family (Apiaceae). FaDOH has been shown to activate PPARγ and to increase the expression of the cholesterol transporter ABCA1 in cells, both of which play an important role in lipid metabolism. Thus, a common mechanism of action of the anticancer and antidiabetic properties of FaDOH may be due to a possible effect on lipid metabolism. In this study, the effect of sub-toxic concentration (5 μM) of FaDOH inside human mesenchymal stem cells (hMSCs) was studied using white light microscopy and Raman imaging. Our results show that FaDOH increases lipid content in the hMSCs cells as well as the number of lipid droplets (LDs) and that this can be explained by increased expression of PPARγ2 as shown in human colon adenocarcinoma cells. Activation of PPARγ can lead to increased expression of ABCA1. We demonstrate that ABCA1 is upregulated in colorectal neoplastic rat tissue, which indicates a possible role of this transporter in the redistribution of lipids and increased formation of LDs in cancer cells that may lead to endoplasmic reticulum stress and cancer cell death.
Isolation and identification of galactinol from castor oilseed meal (1992)

Galactinol, 1‐ O ‐α‐D‐galactopyranosyl‐D‐ myo ‐inositol, is an essential intermediate in the biosynthesis of raffinose saccharides in plant tissues. The unavailability of a commercial source for this metabolite has hindered research on raffinose saccharide metabolism to date. The objective of this study was to develop a facile method for obtaining highly purified galactinol from a readily available source. Defatted castor oilseed meal was found to exhibit a simple soluble carbohydrate profile that included galactinol. Purification of galactinol from castor meal was achieved by enzymatic treatment and a series of liquid chromatography steps, including ion‐exchange and carbon adsorption. The isolation procedure was reliable with a yield of 278 mg of galactinol from 150 g of defatted meal. The purity of galactinol was estimated at 96.4% by high‐performance liquid chromatography. The identity of the purified galactinol was confirmed by enzymatic analysis, identical relative retention times on high‐performance liquid chromatography and gas chromatography, and comparison of its mass spectrum to that of authentic galactinol.
Fatal Cowpox Virus Infection in Cotton-Top Tamarins ( Saguinus oedipus ) in Germany (2014)

Cowpox virus (CPXV) was isolated from a fatal outbreak among cotton-top tamarins. Samples from healthy common marmosets in contact were also CPXV genome positive. The CPXV isolated from the cotton-top tamarins exhibited a unique hemagglutinin sequence. Pathogenicity investigations using a Wistar rat model characterized the isolate as low pathogenic.
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human (2020)

Receptor-mediated transcytosis (RMT) is a principal pathway for transport of macromolecules essential for brain function across the blood-brain barrier (BBB). Antibodies or peptide ligands which bind RMT receptors are often co-opted for brain delivery of biotherapeutics. Constitutively recycling transferrin receptor (TfR) is a prototype receptor utilized to shuttle therapeutic cargos across the BBB. Several other BBB-expressed receptors have been shown to mediate transcytosis of antibodies or protein ligands including insulin receptor (INSR) and insulin-like growth factor-1 receptor (IGF1R), lipid transporters LRP1, LDLR, LRP8 and TMEM30A, solute carrier family transporter SLC3A2/CD98hc and leptin receptor (LEPR). In this study, we analyzed expression patterns of genes encoding RMT receptors in isolated brain microvessels, brain parenchyma and peripheral organs of the mouse and the human using RNA-seq approach. IGF1R, INSR and LRP8 were highly enriched in mouse brain microvessels compared to peripheral tissues. In human brain microvessels only INSR was enriched compared to either the brain or the lung. The expression levels of SLC2A1, LRP1, IGF1R, LRP8 and TFRC were significantly higher in the mouse compared to human brain microvessels. The protein expression of these receptors analyzed by Western blot and immunofluorescent staining of the brain microvessels correlated with their transcript abundance. This study provides a molecular transcriptomics map of key RMT receptors in mouse and human brain microvessels and peripheral tissues, important to translational studies of biodistribution, efficacy and safety of antibodies developed against these receptors.
Design by Optimization (2001)

In many integrated circuit (IC) design situations, a designer must make complex trade-offs between conflicting behavioral requirements, dealing with functions that are often nonlinear. The number of parameters involved in the design process may be large, necessitating the use of algorithms that provide qualitatively good solutions in a computationally efficient manner. This chapter illustrates the theory and utilization of optimization algorithms in computer-aided design (CAD) of ICs. The form of a general nonlinear optimization problem is first presented, and some of the commonly used methods for optimization are overviewed. Case studies on the following specific design problems are examined: transistor sizing and analog design centering. Most problems in IC design involve the minimization or maximization of a cost function subject to certain constraints. The chapter also presents a few prominent techniques for constrained optimization: Lagrange multiplier methods, penalty function methods, and the method of feasible directions.
Thermal and Photo-initiated Crosslinking of Network Polymers and Their Ultimate Film Properties. (2019)

TILLY, JOSEPH.Thermal and Photo-initiated Crosslinking of Network Polymers and Their Ultimate Film Properties (Under the direction of
Thorium reactions in borosilicate-glass/water systems (2005)

Summary Studies were conducted on the dissolution of Th-doped borosilicate glass, a complex assemblage of 24 different elements in various proportions, in a wide range of pH values (0.5 to 12) and carbonate (as high as 6.2 m) and bicarbonate (as high as 1.0 m) concentrations, and as a function of time to determine whether the observed thorium concentrations exhibit an equilibrium phenomenon and to ascertain whether existing thermodynamic data can be used to interpret these results. Measurable Th concentrations were observed in either the very acidic (pH 0.5 to 4) solutions or alkaline solutions containing relatively high carbonate/bicarbonate concentrations. Steady state Th concentrations were reached over time from both the oversaturation and undersaturation directions, indicating that Th concentrations are controlled by an equilibrium solubility phenomenon. The XRD, EXAFS, and thermodynamic analyses of solubility data failed to definitively identify the nature of the solubility-controlling solid in this complex system; however, the data suggests that the solubility-controlling solid most likely involves the Th-silicate phase and that the observed Th concentrations are up to many orders of magnitude lower than in equilibrium with ThO 2 (am). The solubility study also showed that existing thermodynamic data for carbonato complexes of Th can be used to reliably predict Th concentrations in relatively dilute to concentrated carbonate/bicarbonate solutions.
THEORY OF STABILITY OF PERIODIC MULTILAYERED CONTINUA (1964)

The writer's theory of stability of multilayered continua is applied to the case of a periodic alternation of layers of two rubber-like materials of different rigidity in a state of homogeneous finite strain. An exact buckling condition is derived which is remarkably simple. It is solved numerically for the case of layers of equal thickness and the buckling load is plotted as a function of the wavelength for various ratios of the two rigidities. At small wavelength the buckling degenerates into interfacial instability. At large wavelength the instability coincides with internal buckling of an anisotropic continuum equivalent to the multilayered system. The case of layers of different thickness is discussed. By viscoelastic correspondence the results are immediately applicable to viscoelastic media. The general theory also provides a similar solution for layers of anisotropic materials.
In Vivo Pharmacologic Profile of ONO-1078: A Potent, Selective and Orally Active Peptide Leukotriene (LT) Antagonist (1992)

We investigated the in vivo antagonistic activity of ONO-1078 against peptide leukotrienes (LTs) in guinea pigs. ONO-1078, when administered p.o. (0.3–3 mg/kg), caused a dose-dependent reduction of LTC4-, LTD4- and LTE4-induced bronchoconstriction, LTD4-induced airway micro-vascular leakage and LTD4-induced increase in cutaneous vascular permeability. When administered intravenously, ONO-1078 (3–30 μg/kg) inhibited these responses approximately 200–600 fold more potently than FPL55712. When guinea pigs were treated with indomethacin to examine the antagonism of ONO-1078 on the direct action against peptide LTs, intravenous (3–30 μg/kg) and oral (0.3–3 mg/kg) administration of ONO-1078 also inhibited LTC4- and LTD4-induced bronchoconstriction, and its activity was approximately 300–500 fold more potent than that of FPL55712. ONO-1078 (10 mg/kg, i.v.) had no inhibitory effect on bronchoconstrictions induced by histamine, acetylcholine, serotonin, arachidonic acid, LTB4, prostaglandin (PG) F2α, PGD2, 9α,11β-PGF2, a stable thromboxane A2 mimetic agent and platelet activating factor. Furthermore, oral administration of ONO-1078 (1–10 mg/kg) inhibited slow-reacting substance of anaphylaxis mediated bronchoconstriction induced by antigen in a dose-dependent manner. These results indicate that ONO-1078 is an extremely potent, selective and orally active peptide LT antagonist and that oral administration of ONO-1078 antagonizes not only exogenously administered peptide LTs but also endogenous peptide LTs.
‘Inorganics-in-organics’ semiconductors for high energy radiation detection. (2018)

X-ray detectors are an invaluable tool for healthcare diagnostics, cancer therapy, homeland security and non-destructive evaluation among many fields. However, potential uses for X-rays are limited by system cost and/or detector dimensions. Current X-ray detector sensitivities are limited by the bulk X-ray attenuation of the materials and consequently necessitates thick crystals with dimensions of ~ 1 mm – 1 cm, resulting in rigid structure, high operational voltages and high cost. Semiconducting polymer X-ray detectors are an emerging low cost technology. Their solution processable nature enables the fabrication of such detectors on flexible substrates over large areas using printing and roll-to-roll coating techniques. However, the low atomic number (Z) of organic materials results in low X-ray attenuation and hence, low X-ray sensitivities. This thesis focuses on direct detection of X-rays using organic semiconducting systems incorporating high Z Bi2O3 nanoparticles (NPs). For the work discussed, a thick organic bulk heterojunction (~10 – 20 μm) consisting of the p-type poly(3-hexylthiophene-2,5-diyl) (P3HT) and the n type [6,6]-Phenyl C71 butyric acid methyl ester (PC70BM) are utilised. The effectiveness on the utilisation of a dual carrier system is demonstrated through the fabrication of detectors in a diode architecture by varying the NP loading from 0 – ~50% (by wt.). These hybrid detectors demonstrate sensitivities of 1712 μC mGy-1 cm-3 when irradiated under 50 kV tungsten X-ray source and ~30 and 58 μC mGy-1 cm-3 under 6 and 15 MV X-rays generated from a medical linear accelerator. A flexible detector was fabricated which demonstrated a high sensitivity approaching 300 μC mGy-1 cm-3, highlighting the promise of the technology for dosimetry and imaging in non-planar architectures. These performances are discussed based on the structural and electrical characteristics of the hybrid thick film diodes. Possible mechanisms for the high sensitivity observed are proposed where photoconducting gain, impact ionisation and Mie scattering are identified as central contributors towards the detector sensitivity. Routes to increasing the detector thickness to 100 μm – 1 mm thickness range is demonstrated using a pellet based on powder sintering technique. These P3HT:PC70BM:Bi2O3 detectors operate as photoconductors showing X-ray sensitivities in the region of ~ 160 C mGy-1 cm-3 and a preliminary X-ray imager based on the pellets are fabricated. Finally, potential routes for further improvement of the detector characteristics are discussed.
Resistivity While Drilling. Images from the string (1996)

Resistivity measurements made while drilling have evolved from the simple short normal devices of the early 1980s to sophisticated multitransmitter and multielectrode devices of the 1990s. In this article the latest logging while drilling resistivity tools with applications ranging from invasion profiling to image and dip analysis are discussed: the ARC5 Array Resistivity Compensated tool and RAB Resistivity-at-the-Bit tool. 23 figs., 22 refs.
A New Fractional-Order Chaotic System with Different Families of Hidden and Self-Excited Attractors (2018)

In this work, a new fractional-order chaotic system with a single parameter and four nonlinearities is introduced. One striking feature is that by varying the system parameter, the fractional-order system generates several complex dynamics: self-excited attractors, hidden attractors, and the coexistence of hidden attractors. In the family of self-excited chaotic attractors, the system has four spiral-saddle-type equilibrium points, or two nonhyperbolic equilibria. Besides, for a certain value of the parameter, a fractional-order no-equilibrium system is obtained. This no-equilibrium system presents a hidden chaotic attractor with a `hurricane'-like shape in the phase space. Multistability is also observed, since a hidden chaotic attractor coexists with a periodic one. The chaos generation in the new fractional-order system is demonstrated by the Lyapunov exponents method and equilibrium stability. Moreover, the complexity of the self-excited and hidden chaotic attractors is analyzed by computing their spectral entropy and Brownian-like motions. Finally, a pseudo-random number generator is designed using the hidden dynamics.
An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression. (2001)

Katja Issbrücker’s name was printed incorrectly. The correct spelling is shown above.
On implementing behavioral rewriting (2002)

Behavioral specification is an important algebraic method in software technology. A subtle aspect of behavioral specification is that operations may not be compatible with the behavioral (or observational) equivalence, meaning that the typical congruence inference rule may not be sound and, implicitly, that standard term rewriting cannot be used as is to execute behavioral specifications. Behavioral rewriting is an appropriate generalization of term rewriting which is already internally implemented in two behavioral specification and verification systems, CafeOBJ and BOBJ. In this paper we propose two alternative solutions to implement behavioral rewriting, on top of almost any standard term rewriting system, without modifying it internally.
Ultrasound-Derived Features of Muscle Architecture Provide Unique Temporal Characterization of Volitional Knee Motion (2021)

Sonomyography, or dynamic ultrasound imaging of skeletal muscle, has gained significant interest in rehabilitation medicine. Previously, correlations relating sonomyography features of muscle contraction, including muscle thickness, pennation angle, angle between aponeuroses and fascicle length, to muscle force production, strength and joint motion have been established. Additionally, relationships between grayscale image intensity, or echogenicity, with maximum voluntary isometric contraction of muscle have been noted. However, the time relationship between changes in various sonomyography features during volitional motion has yet to be explored, which would highlight if unique information pertaining to muscle contraction and motion can be obtained from this real-time imaging modality. These new insights could inform how we assess muscle function and/or how we use this modality for assistive device control. Thus, our objective was to characterize the time synchronization of changes in five features of rectus femoris contraction extracted from ultrasound images during seated knee extension and flexion. A cross-correlation analysis was performed on data recorded by a handheld ultrasound system as able-bodied subjects completed seated trials of volitional knee extension and flexion. Changes in muscle thickness, angle between aponeuroses, and mean image echogenicity, a change in brightness of the grayscale image, preceded changes in our estimates of pennation angle and fascicle length. The leading nature of these features suggest they could be objective features for early detection of impending joint motion. Finally, multiple sonomyographic features provided unique temporal information associated with this volitional task.Clinical Relevance-This work evaluates the time relationship between five commonly reported features of skeletal muscle architecture during volitional motion, which can be used for targeted clinical assessments and intent detection.
Two-dimensional model of the ignition phase of high-pressure glow discharges (1994)

A self-consistent two-dimensional (2D) model of large volume inhomogeneously preionized transient high-pressure glows as used in XeCl lasers is described. The basic concept is to use a curvilinear orthogonal coordinate system generated by conformal mapping of a cartesian system. The model uses the local field approximation and is based on a cartesian 2D model of J.-P. Boeuf and L. C. Pitchford [IEEE Trans. Plasma Sci. 19, 286 (1991)]. As only direct ionization is taken into account, applications are limited to the ignition phase. Application to a discharge between cylindrical rods predicts a high degree of E-field homogenization due to space charges and demonstrates the limits of parallel resistor models. Inside the cathode sheath an explosive formation of a very thin highly ionized layer is predicted. This sheath ignition is also seen in experiments.
Correction to High-Resolution Structural Characterization of Two Layered Aluminophosphates by Synchrotron Powder Diffraction and NMR Crystallographies (2016)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to High-Resolution Structural Characterization of Two Layered Aluminophosphates by Synchrotron Powder Diffraction and NMR CrystallographiesBoris Bouchevreau, Charlotte Martineau*, Caroline Mellot-Draznieks, Julien Dutour, Alain Tuel, Matthew R. Suchomel, Julien Trébosc, Olivier Lafon, Jean-Paul Amoureux, and Francis Taulelle*Cite this: Chem. Mater. 2016, 28, 14, 5172Publication Date (Web):July 1, 2016Publication History Published online1 July 2016Published inissue 26 July 2016https://pubs.acs.org/doi/10.1021/acs.chemmater.6b02372https://doi.org/10.1021/acs.chemmater.6b02372correctionACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views417Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (146 KB) Get e-Alertsclose Get e-Alerts
An analysis of radio fingerprints behavior in the context of RSS-based location fingerprinting systems (2011)

Location Fingerprinting is a localization technique which uses a radio database as the key element for the positioning process. Performance of location fingerprinting systems has been analyzed empirically in some previous works. However, there is a lack of theoretical models that analyze and predict the fingerprints behavior under different physical situations. In this work we present an analysis to evaluate the distinctiveness of fingerprints in a local neighborhood, in the context of cellular radio fingerprinting. The model is developed assuming the presence of correlated log-normal shadowing. Based on the presented analysis, we conclude some general guidelines for design and implementation of radio databases in fingerprinting systems.
Study on characteristics of nozzle flapper system considering flow force (2000)

A pneumatic nozzle flapper is an important displacement pressure converting element in pneumatic control systems. Recently, the drive current applied to a nozzle flapper tends to be smaller for saving the electric power and the drive force of the flapper is considered to be on the order of the flow force. As a result, the flow force influences the flapper displacement. So it is necessary to predict accurately the characteristics of the nozzle flapper. In this paper, the pneumatic nozzle flapper model including flow force of air jet through nozzle is proposed and the characteristics of the flow force are experimentally analyzed by the frequency response tests. There are 2 kind of the flow forces, that is, the flow force of static pressure and dynamic pressure, however the flow force of dynamic pressure is a negligible quantity, when the pneumatic nozzle flapper is designed.