gebhart/patrepeval huggingface dataset:
Temperature-Sensitivity Analysis of 1360-nm Dilute-Nitride Quantum-Well Lasers (2004)

The N-content of an InGaAsN quantum-well (QW) laser is found to dramatically affect the temperature sensitivity of the current injection efficiency (/spl eta//sub inj/) and material gain parameter (g/sub oJ/). The increased temperature sensitivity of /spl eta//sub inj/ and g/sub oJ/ of InGaAsN QW lasers with increasing N-content leads to a significant increase in their temperature sensitivity of threshold current and external differential quantum efficiency. Increasing the N-content of the InGaAsN QW potentially results in a reduction of the heavy hole confinement, which may account for the increased temperature sensitivity of the current injection efficiency.
Repeatability of sodium and chloride in exhaled breath condensates (2004)

Exhaled breath condensate (EBC) has been proposed as a noninvasive tool to study airway inflammation. The reproducibility of breath condensates was recently questioned. We therefore measured sodium and chloride concentrations in EBC and assessed the repeatability of these measurements in healthy adults and children with airway disease. We investigated technical repeatability and within-day repeatability in five healthy adults, and compared these results with those of 10 asthmatic children and 9 children with cystic fibrosis (CF). We also assessed within-period repeatability in the healthy controls. We report that the variability of measurements was similar for within sample, within day, and between visits, for both normals and children with asthma and CF, and that the major source of variability of sodium and chloride measurements is restricted by the reproducibility of the measurement assay method used. The wide use of EBC is more likely to depend on the development of highly sensitive and reproducible assays, rather than further refinements of the collection technique.
Feeding behavior in dopamine-deficient mice (1999)

Mice that cannot make dopamine (DA), a condition caused by the selective inactivation of tyrosine hydroxylase in dopaminergic neurons, are born normal but gradually become hypoactive and hypophagic, and die at 3 weeks of age. We characterized the feeding and locomotor responses of these DA-deficient (DA-/-) mice to 3, 4-dihyroxy-L-phenylalanine (L-DOPA) to investigate the relationship between brain DA levels and these complex behaviors. Daily administration of L-DOPA to DA-/- mice stimulated locomotor activity that lasted 6 to 9 hr; during that time the mice consumed most of their daily food and water. The minimal dose of L-DOPA that was sufficient to elicit normal feeding behavior in the DA-/- mice also restored their striatal DA to 9.1% of that in the wild-type (WT) mice at 3 hr; then DA content declined to <1% of WT levels by 24 hr. This dose of L-DOPA induced locomotor activity that exceeded that of treated WT mice by 5- to 7-fold, suggesting that DA-/- mice are supersensitive to DA. Unexpectedly, DA-/- mice manifested a second wave of activity 24 to 48 hr after L-DOPA treatment that was equivalent in magnitude to that of WT mice and independent of DA receptor activation. The DA-/- mice approached, sniffed, and chewed food during this second period of activity, but they ate <10% of that required for sustenance. Therefore, DA-/- mice can execute behaviors necessary to seek and ingest food, but they do not eat enough to survive.
Supplementary Data from Lynch Syndrome–Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry (2023)

Supplementary Data from Lynch Syndrome–Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry
The Aura Software Architecture: an Infrastructure for Ubiquitous Computing (2018)

Abstract: "Computing environments of the future should enable mobile users to take full advantage of the computing capabilities available at each location, while allowing them to focus on their real tasks, rather than being distracted by dealing with the configuration and reconfiguration of computer systems to support those tasks. The Aura infrastructure performs automatic configuration and reconfiguration of Ubicomp environments, according to the user's task and intent. This report describes the software architecture of the Aura infrastructure, and discusses the underlying rational. It describes the architecture from a layered perspective, detailing the partition of responsibility and shared assumptions, as well as from a component-connector perspective, detailing the protocols of interaction between the components (APIs and sequencing). The contents and format of the exchanged messages is extensively discussed, as well as the details pertaining [sic] service interconnection and decomposition. This report proposes a utility-based approach for modeling user preferences, and details how such models can be exploited for both coarse-grain automatic (re)configuration, and fine-grain adaptation to resource change."
Analysis of BFSK frequency-hopped spread-spectrum multiple-access over a Rayleigh fading channel (2002)

Frequency-hopped spread-spectrum multiple-access over a Rayleigh fading channel is considered when the modulation used is noncoherent BFSK. An expression for the probability of a code symbol error as a function of the number of users, the number of sub-bands and the signal-to-noise ratio is derived. This expression is easily evaluated numerically, and is used to find the code rate that maximizes the throughput for a predetermined error probability when binary BCH codes are employed. The cutoff rate for the random ensemble of codes is also studied, and the result is compared with the performance of specific codes. Further, the effect of background noise, often neglected in this type of problem, is studied and its impact on the performance of the system is found to be severe.
Growth tethering devices for idiopathic scoliosis (2015)

Adolescent idiopathic scoliosis is a 3D spine deformity that worsens during the whole growth. The treatments available are bracing during the whole growth to avoid progression of the deformity and surgical fusion of the spine at skeletal maturity for the most severe curves. Recent advances in flexible spinal implants have given rise to new expectations in the management of progressive scoliosis with growth modulation without fusion. For the first time, treatment allows us to expect a correction of progressive curves without fusion. This review discusses the recent developments in the field of spinal growth modulation techniques and discusses the pros and cons of the medical devices used in this indication.
Nutrient dynamics and gas production in aquatic ecosystems: The effects and utilization of mercury and nitrogen in sediment-water microcosms (1975)

Sixteen sediment-water microcosms designed to allow complete gas, liquid, and solid mass balances of gases, nutrients, and mercury were studies under dark conditions or varying light intensity for a period of 189 days. Results indicated that the microcosm technique is a very sensitive method of analyzing microbial dynamics in sediment water systems. Gas quantity and composition changes were easy to monitor and were especially sensitive to light and nutrient variations. Nitrogen fixation occurred in all lighted systems (blue-green algae nitrogen fixers, Anabaena, and others) and was adequate to insure that no nitrogen limitation occurred even though nitrogen limitation was imposed on the system. Sediments apparently did not act as a significant source of nitrogen. Iron and phosphorus were in excess and as such were closely linked as would be predicted on the basis of chemical equilibria. Non-equilibrium chemical behavior of such elements would apparently result only when appreciable amounts of the compound or element is utilized in growth.
Hysweet® Technology: A Major Progress in Sour Gas Processing (2012)

Abstract Removing mercaptans from sour natural gas is becoming an important issue with the global trend towards more stringent specifications for commercial gases. Amines have been extensively used on account of their ability to meet severe H2S and CO2 specifications and very high acid gas selectivity over hydrocarbons. Amines however present very limited mercaptans removal capabilities, an additional treatment step is generally required to achieve a stringent specification of total sulfur specification in the sales gas or upstream liquefaction plant. Total, taking advantage of its extensive know-how and experiences in acid gas removal, has developed the HySWEET® processes, for simultaneous absorption of acid gases and mercaptans. This technology relies on a new hybrid solvent formulation allowing limited coabsorption of hydrocarbons and improved energy efficiency. The HySWEET® process has been in operation since 2008, and the entire gas production of the Lacq plant, France is now treated with this new hybrid solvent. The industrial feedback has confirmed not only higher mercaptan removal, but also lower energy consumption when compared to the AdvAmine™ HiLoadDEA process which has allowed for Lacq gas treatment during most of the lifetime of the field. The development of the HySWEET®DEA process is now completed and ready for commercialization. An optimized design can now be proposed for any application case targeting total CO2 and H2S removal along with a stringent total sulfur specification. Thousands of laboratory measurements (i.e. thermodynamics, kinetics, physical properties) have been used to develop a rigorous simulation tool which relies on rate-based transfer models validated against extensive pilot and operational test-runs. The HySWEET®MDEA process is under development, for the selective elimination of sulfur compounds over CO2. Improved mercaptan removal and high energy efficiency have been demonstrated during pilot tests. These pilot test results will be later used to validate the prediction of the simulation tool currently under development. This paper provides a review of the HySWEET® technology: an update on the HySWEET®DEA process and the latest R&amp;D developments of HySWEET®MDEA.
Inactivation of the {beta}-subunit of lysosomal {beta}-hexosaminidase by targeted disruption of the HEXB gene in mice (1994)

{beta}-Hexosaminidase is a lysosomal enzyme that catalyzes the hydrolysis of ganglioside G{sub M2} and other substances. Two major catalytically active isozymes are expressed in human tissues: Hex A (a{beta}) and Hex B ({beta}{beta}). Sandhoff disease is a rare autosomal recessive disorder caused by mutations in the HEXB gene, inactivating both isoenzymes. We have characterized the structure of the mouse HEXB gene from the strain 129/Sv. It contains 14 exons in a span of 22 kb; a 1200 by 5{prime}-sequence showed promoter activity when expressed in monkey COS cells. A survey of mRNA levels in mouse tissues showed the highest levels in kidney and epididymis, with brain intermediate, and lung, testis and liver with the lowest levels. We used homologous recombination of a distrupted HEXB gene to inactivate the endogenous gene in pluripotent embryonic stem (ES) cells. The sequence replacement vector contained {approximately}11 kb of the mouse HEXB gene (exons 1-5) and was interrupted in the second exon with the neomycin-resistance (neo{sup r}) gene. The targeting vector was introduced into male CGR8 ES cells by electroporation followed by selection for G418-resistant colonies. Analysis of the genomic DNA of 100 independent colonies by Southern blot allowed us to identify six cell linesmore » with the expected band pattern generated by specific recombination at the targeted site. Cells of three of the cell lines were microinjected into C57BL/6J blastocysts in order to generate chimeric mice. Three chimeric males were obtained with ES cell contributions ranging from 80 to 95% as judged by the proportion of agouti coat color. These chimeras are currently being bred with C57BL/6J mice for the generation of HEXB heterozygous and homozygous mice.« less
Biodiesel production by hydroesterification of microalgal biomass using heterogeneous catalyst (2012)

This paper assesses the hydroesterification process for the production of Biodiesel from Monoraphidium contortum (MORF-1) microalgae biomass, as it is a sustainable alternative not only economically, but also environmentally and ecologically to replace petroleum diesel fuel. The Biodiesel studied in this work was obtained from fatty acid esterification, a product of microalgae and methanol biomass hydrolysis reaction. CBMM’s (HY-340) niobium oxide powder was used as catalyst. The reactions were carried out in a properly closed autoclave reactor (batch), where the reagents were mixed under constant stirring at 500 rpm for hydrolysis and esterification. The products generated were submitted to gas chromatography and oxidative stability analysis. The hydroesterification process showed itself to be a promising alternative to the conventional biodiesel production process (transesterification) as it favors the use of feedstocks with any acidity and moisture content and may be performed with acid catalyst, which favors high conversions in a small range of time (30 minutes).
A Highly Scalable Key-Value Storage System for Latency Sensitive Applications (2009)

This paper presents the design of a highly scalable key-value storage system for building latency sensitive applications. To be able to scale up to an extremely large system, the design adopts a decentralized and symmetrical architecture and uses consistent hashing for partitioning. Every node keeps a full membership of all the nodes in the system and can route a lookup in one hop. Server and network failures occur at any time and the storage system is dynamic for nodes join and leave the system continually. We design a hierarchical gossip based membership protocol to capture the accurate membership information of the system with acceptable memory and communication overhead. The system also replicates data items on multiple nodes to achieve high availability and high durability.
Near infrared spectrometric technique for testing fruit quality: optimisation of regression models using genetic algorithms (2017)

Near infrared (NIR) spectroscopy has gained extensive use in quality evaluation. It is arguably one of the most advanced spectroscopic tools in non-destructive quality testing of food stuff, from measurement to data analysis and interpretation. NIR spectral data are interpreted through means often involving multivariate statistical analysis, sometimes associated with optimisation techniques for model improvement. The objective of this research was to explore the extent to which genetic algorithms (GA) can be used to enhance model development, for predicting fruit quality. Apple fruits were used, and NIR spectra in the range from 12000 to 4000 cm<sup>-1</sup> were acquired on both bruised and healthy tissues, with different degrees of mechanical damage. GAs were used in combination with partial least squares regression methods to develop bruise severity prediction models, and compared to PLS models developed using the full NIR spectrum. A classification model was developed, which clearly separated bruised from unbruised apple tissue. GAs helped improve prediction models by over 10%, in comparison with full spectrum-based models, as evaluated in terms of error of prediction (Root Mean Square Error of Cross-validation). PLS models to predict internal quality, such as sugar content and acidity were developed and compared to the versions optimized by genetic algorithm. Overall, the results highlighted the potential use of GA method to improve speed and accuracy of fruit quality prediction.
Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3 (2008)

The regulation of cellular stress responses to electrophiles and oxidants is mediated by the transcription factor NF-E2-related factor 2 (Nrf2), which, in turn, is regulated by CUL-E3 (CUL3) ligase-mediated ubiquitylation. The Kelch-like ECH-associated protein 1 (Keap1) serves as an adapter between CUL3 and Nrf2. We used the model electrophile N-iodoacetyl- N-biotinylhexylenediamine (IAB) to define the relationship among the adduction of Keap1 cysteine residues, structure, and function. Exposure of Keap1 to IAB in vitro was accompanied by progressive loss of protein secondary structure, as monitored by CD spectroscopy and a loss of the ability to associate with recombinant CUL3. Dissociation of Keap1 from CUL3 in vitro was dependent upon C151 in Keap1. A quantitative mass spectrometry-based kinetic analysis of adduction in HEK293 cells expressing FLAG-Keap1 revealed that Cys151 was one of the most reactive residues in vivo and that it was required for IAB-mediated dissociation of the Keap1-CUL3 interaction. These results demonstrate that Cys151 adduction confers a critical alkylation sensor function upon Keap1, making Keap1 unique among BTB CUL3 adapter proteins.
Consensus inside (2014)

Scaling to a large number of cores with non-uniform communication latency and unpredictable response time may call for viewing a modern many-core architecture as a distributed system. In this view, the cores replicate shared data and ensure consistency among replicas through a message-passing based agreement protocol.
Potential survival gains in the treatment of myocardial infarction (2009)

Potential gains from improved clinical effectiveness in MI care are likely to compare favourably with benefits achieved though innovations, and should inform priorities in research and implementation strategies for improving MI outcomes.
Lattice Structure Optimization With Orientation-Dependent Material Properties (2021)

Abstract Advances in additive manufacturing (AM) techniques have enabled the production of parts with complex internal geometries. However, the layer-based nature of additive processes often results in mechanical properties that vary based on the orientation of the feature relative to the build plane. Lattice structures have been a popular design application for additive manufacturing due to their potential uses in lightweight structural applications. Many recent works have explored the modeling, design, and fabrication challenges that arise in the multiscale setting of lattice structures. However, there remains a significant challenge in bridging the simplified computational models used in the design process and the more complex properties actually realized in fabrication. This study develops a design approach that captures orientation-dependent material properties that have been observed in metal AM processes, while remaining suitable for use in an iterative design process. Exemplar problems are utilized to investigate the potential design changes and performance improvements that can be attained by taking the directional dependence of the manufacturing process into account in the design of lattice structures.
Complicaciones Obstétricas (2015)

Biología molecular de la asfixia fetal. Restricción del crecimiento intrauterino. Toma de decisiones en los casos de restricción de crecimiento intrauterino. Nuevas evidencias en el manejo de la placenta previa. Manejo expectante de los trastornos gestacionales hipertensivos leves. Preeclampsia severa y síndrome Hellp. Situación de la prematuridad en el Perú. Longitud del cérvix en la predicción del parto prematuro. Uso de sulfato de magnesio antenatal para prevenir la parálisis cerebral en prematuros. Uso de pesarios en el parto prematuro. Uso de misoprostol en la hemorragia post parto. Embarazo múltiple manejo anteparto. Embarazo múltiple: Manejo intraparto,¿parto vaginal o cesárea?.
Nondestructive Testing Resolution: Electromagnetic Waves versus Seismic Ones (2005)

The practical limits on resolution of images from seismic or radar (electromagnetic) data depend on the spectrum of the source pulse, the incompleteness of the recording ge ometry, and the fidelity with which one can model the reference medium. These factors together prevent one from recovering a point image from data produced by a point diffractor in a given body. A simple imaging f ormula quantifies the effect of the source pulse spectru m, showing that spatial wavelet extent in an imaged volume is related to the product of the local velocity and the period of the propagating pulse. A general scheme for estimating the effect on resolution of the recording geo metry is applied to various recording geometries in modeled concrete slabs for seismic and electromagnetic waves. The penetration of electromagnetic waves, generated fro m Radar instruments, into media like concrete, have similar kinematic properties to the seismic (ultrasoni c) ones, differ in their dynamic and response behavior. Using finite difference numerical modeling, as well as physi cal observations, we realized that features in media, such as voids, appear differently on GPR sections versus seismic ones. Part of the difference is attributed to the wa ve velocity difference for the two waveforms for air and water filled voids, resulting in difference in appearance and resolution. Despite the much higher frequencies associated with Radar el ectromagnetic waves, the higher frequencies are well compensated by the high velocity of such waves result ing in wavelengths similar to those experienced in seismic experiments. Nevertheless, due to the single mo de nature of electromagnetic waves, we obtain better scattering behavior (cleaner) using radar data than what can be obtained using seismic ones. The scattering re sponse of seismic waves includes the conversion of part of the energy to other modes (i.e. shear modes). These modes can potentially provide additional information, but requires care ful analysis.
Supplementary Figure 1 from Nanoparticles Engineered with Rituximab and Loaded with Nutlin-3 Show Promising Therapeutic Activity in B-Leukemic Xenografts (2023)

&lt;p&gt;PDF file - 307K, Supplementary Figure 1. Evidence of NP entry into cells.&lt;/p&gt;
Use Of The Nonsense-Syllable In Articulation Therapy (1957)

No AccessJournal of Speech and Hearing DisordersResearch Article1 Jun 1957Use Of The Nonsense-Syllable In Articulation Therapy George H. Shames George H. Shames Google Scholar More articles by this author https://doi.org/10.1044/jshd.2202.261 SectionsAboutPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Additional Resources FiguresReferencesRelatedDetailsCited by Language and Speech16:1 (44-56)1 Jan 1973Referential Effects on Articulatory LearningLaurence B. Leonard Richard Luchsinger and Gottfried E. Arnold (1970) Zentrale Entwicklungshemmungen der Sprache Handbuch der Stimm- und Sprachheilkunde10.1007/978-3-7091-7130-1_15 Journal of Communication Disorders1:3 (215-235)1 Apr 1968Relation between sound discrimination and sound learningHarris Winitz and Betty Bellerose Journal of Verbal Learning and Verbal Behavior4:2 (98-102)1 Apr 1965Phoneme-cluster learning as a function of instructional method and ageHarris Wintz and Betty Bellerose Volume 22Issue 2June 1957Pages: 261-263 Get Permissions Add to your Mendeley library History Published in issue: Jun 1, 1957PubMed ID: 13429669 Metrics Topicsasha-topicsasha-article-typesleader-topicsCopyright & PermissionsCopyright © 1957 American Speech-Language-Hearing AssociationPDF downloadLoading ...