gebhart/patrepeval huggingface dataset:
Common variable immunodeficiency in three horses with presumptive bacterial meningitis (2005)

Three adult horses were evaluated for signs of musculoskeletal pain, dullness, ataxia, and seizures. A diagnosis of bacterial meningitis was made on the basis of results of CSF analysis. Because primary bacterial meningitis is so rare in adult horses without any history of generalized sepsis or trauma, immune function testing was pursued. Flow cytometric phenotyping of peripheral blood lymphocytes was performed, and proliferation of peripheral blood lymphocytes in response to concanavalin A, phytohemagglutinin, pokeweed mitogen, and lipopolysaccharide was determined. Serum IgA, IgM, and IgG concentrations were measured by means of radial immunodiffusion, and serum concentrations of IgG isotypes were assessed with a capture antibody ELISA. Serum tetanus antibody concentrations were measured before and 1 month after tetanus toxoid administration. Phagocytosis and oxidative burst activity of isolated peripheral blood phagocytes were evaluated by means of simultaneous flow cytometric analysis. Persistent B-cell lymphopenia, hypogammaglobulinemia, and abnormal in vitro responses to mitogens were detected in all 3 horses, and a diagnosis of common variable immunodeficiency was made.
Negative permittivity and permeability of gold square nanospirals (2009)

The optical properties of square nanospirals made of gold have been investigated numerically in the hundred terahertz range as a function of the geometrical parameters of the nanospirals. It is shown that the permittivity values of the nanospirals originate from the longitudinal surface plasmon resonances of the arms composing the nanospirals. A magnetic resonance was also observed whose magnitude and position increased with the number of winding. Above three windings the gold nanospirals exhibited negative values of the real part of the permeability above 400 THz.
IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation (2010)

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the CNS. Recent advances in whole-genome screening tools have enabled discovery of several MS risk genes, the majority of which have known immune-related functions. However, disease heterogeneity and low tissue accessibility hinder functional studies of established MS risk genes. For this reason, the MS model experimental autoimmune encephalomyelitis (EAE) is often used to study neuroinflammatory disease mechanisms. In this study, we performed high-resolution linkage analysis in a rat advanced intercross line to identify an EAE-regulating quantitative trait locus, Eae29, on rat chromosome 1. Eae29 alleles from the resistant strain both conferred milder EAE and lower production of proinflammatory molecules in macrophages, as demonstrated by the congenic line, DA.PVG-Eae29 (Dc1P). The soluble IL-22R α2 gene (Il-22ra2) lies within the Eae29 locus, and its expression was reduced in Dc1P, both in activated macrophages and splenocytes from immunized rats. Moreover, a single nucleotide polymorphism located at the end of IL-22RA2 associated with MS risk in a combined Swedish and Norwegian cohort comprising 5019 subjects, displaying an odds ratio of 1.26 (p = 8.0 × 10(-4)). IL-22 and its receptors have been implicated in chronic inflammation, suggesting that IL-22RA2 regulates a central immune pathway. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of MS patients, we establish IL-22RA2 as an MS risk gene.
OPTIMIZED MULTI-ATLAS PROSTATE SEGMENTATION FROM 3D CT IMAGES (2019)

International audience
Mirror Mirror (2016)

Virtual fitting rooms equipped with magic mirrors let people evaluate fashion items without actually putting them on. The mirrors superimpose virtual clothes on the user's reflection. We contribute the Mirror Mirror system, which not only supports mixing and matching of existing fashion items, but also lets users design new items in front of the mirror and export designs to fabric printers. While much of the related work deals with interactive cloth simulation on live user data, we focus on collaborative design activities and explore various ways of designing on the body with a mirror.
Homocysteine and Cognitive Decline in Healthy Elderly (2001)

Serum homocysteine is increased, and correlates inversely with cognitive scores, in Alzheimer's disease (AD), vascular dementia and "age-associated memory impairment". Elevated levels might signal accelerated cognitive decline, although this remains to be established. We therefore repeated Mini-Mental State Examinations, together with additional ADAS-Cog assessments, in 32 healthy elderly individuals to determine whether prior homocysteine levels predicted cognitive changes over a 5-year period. Homocysteine predicted follow-up cognitive scores and rate of decline in cognitive performance independently of age, sex, education, renal function, vitamin B status, smoking and hypertension (p < 0.001). Homocysteine predicted word recall (p = 0.01), orientation (p = 0.02) and constructional praxis scores (p < 0.0001). One subject, with the second highest initial homocysteine, had developed probable AD at follow-up. Fasting total serum homocysteine appears to be an independent predictor of cognitive decline in healthy elderly and exerts a maximal effect on spatial copying skills.
Neural crest emigration from the neural tube depends on regulated cadherin expression (1998)

During the emergence of neural crest cells from the neural tube, the expression of cadherins dynamically changes. In the chicken embryo, the early neural tube expresses two cadherins, N-cadherin and cadherin-6B (cad6B), in the dorsal-most region where neural crest cells are generated. The expression of these two cadherins is, however, downregulated in the neural crest cells migrating from the neural tube; they instead begin expressing cadherin-7 (cad7). As an attempt to investigate the role of these changes in cadherin expression, we overexpressed various cadherin constructs, including N-cadherin, cad7, and a dominant negative N-cadherin (cN390 ), in neural crest-generating cells. This was achieved by injecting adenoviral expression vectors encoding these molecules into the lumen of the closing neural tube of chicken embryos at stage 14. In neural tubes injected with the viruses, efficient infection was observed at the neural crest-forming area, resulting in the ectopic cadherin expression also in migrating neural crest cells. Notably, the distribution of neural crest cells with the ectopic cadherins changed depending on which constructs were expressed. Many crest cells failed to escape from the neural tube when N-cadherin or cad7 was overexpressed. Moreover, none of the cells with these ectopic cadherins migrated along the dorsolateral (melanocyte) pathway. When these samples were stained for Mitf, an early melanocyte marker, positive cells were found accumulated within the neural tube, suggesting that the failure of their migration was not due to differentiation defects. In contrast to these phenomena, cells expressing non-functional cadherins exhibited a normal migration pattern. Thus, the overexpression of a neuroepithelial cadherin (N-cadherin) and a crest cadherin (cad7) resulted in the same blocking effect on neural crest segregation from neuroepithelial cells, especially for melanocyte precursors. These findings suggest that the regulation of cadherin expression or its activity at the neural crest-forming area plays a critical role in neural crest emigration from the neural tube.
Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa (2001)

We show for the first time that fasting plasma levels of the novel appetite-modulating hormone ghrelin are elevated in anorexia nervosa and return to normal levels after partial weight recovery. These observations suggest the possible existence of ghrelin resistance in cachectic states such as caused by eating disorders. Future studies are necessary to investigate putative mechanisms of ghrelin resistance such as a possible impairment of intracellular ghrelin receptor signaling in pathophysiological states presenting with cachexia.
Formal Verification of Consistency in Model-Driven Development of Distributed Communicating Systems and Communication Protocols (2006)

Currently UML2 is widely used for modelling software-intensive systems. Model driven development of complex software typically starts from abstract, high-level UML2 models which specify the system from several different viewpoints. Abstract models are further refined into more detailed design models in successive development stages. While specifying various aspects and abstraction levels of such systems, we create a set of different models, which should be inter- and intra-consistent. In this paper we propose an approach to ensuring consistency in Lyra – a rigorous, service-oriented and model-based method for developing industrial telecommunication systems and communication protocols. We derive informal requirements to ensuring intra- and inter-consistency and then formalize them in the B Method. The formalization in B allows us to structure complex informal requirements and formally ensure intra- and inter-consistency of models created at various stages of the Lyra development.
Combined Effect of Polytetrafluoroethylene and 5-Fluorouracil on Delayed Adjustable Strabismus Surgery (2000)

The combined use of PTFE, 5-FU and Viscoat is useful for delaying suture adjustment in rabbit eyes.
Existence and estimates of twin positive solution for two-point right focal boundary value problems (1997)

We consider the following boundary value problem where 1≤p≤n−1 is fixed. Criteria are developed for the existence of two positive solutions of the boundary value problem. For special cases we also establish upper and lower bounds for these positive solutions. Several examples are included to dwell upon the importance of the results obtained.
Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis (1997)

CTLs lyse Fas-expressing target cells by the concomitant action of a perforin- and a Fas-dependent mechanism. This study analyzed whether target cells pulsed with T cell antagonists and other altered peptide ligands (APLs) were susceptible selectively to only one of these two mechanisms. In vivo and in vitro activated T cells from transgenic mice expressing a TCR specific for lymphocytic choriomeningitis virus were used as effector cells. To distinguish between perforin- and Fas-dependent cytotoxicity, T cells from normal or perforin-deficient mice were used to lyse peptide-pulsed Fas-positive or Fas-negative target cells. In contrast to previous reports that have shown that APLs selectively induce the Fas-dependent pathway of cytotoxicity, our results demonstrate that target cells pulsed with T cell antagonists and other APLs are lysed predominantly by the perforin-dependent pathway. The contribution of Fas-mediated cytotoxicity was similar for the full agonist and the APLs. Thus, full agonists, partial agonists, and antagonists trigger similar and not distinct pathways of cytotoxicity.
Conversions of 2‐(2‐Oxocyclohexylcarbonyl)benzoic Acid Derivatives to Pyrazolo[5,1‐a]isoindole and Pyrimidine Rings. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Electroquasistatic quasi‐3D finite element simulation of a graded surge arrester (2019)

Abstract Surge arresters of station class are equipped with field grading elements that break the rotational symmetry of the arrester body. To avoid a computationally expensive full three‐dimensional (3D) simulation, a quasi‐3D simulation procedure is presented to study graded arresters. The method employs a hybrid discretization combining a two‐dimensional (2D) axisymmetric finite element (FE) method in axial and radial direction with a spectral element method in terms of trigonometric functions in azimuthal direction. Furthermore, the asymmetric boundary conditions associated with the support rods are taken into account by collocation in a saddle‐point system of equations. The method is validated and compared with a standard 3D FE simulation of a test problem. It is, subsequently, applied to study the electric field distribution of a graded station class surge arrester.
Hydroxy Polyketones. II. Dibenzoylcarbinol (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxy Polyketones. II. DibenzoylcarbinolA. H. Blatt and W. Lincoln HawkinsCite this: J. Am. Chem. Soc. 1936, 58, 1, 81–84Publication Date (Print):January 1, 1936Publication History Published online1 May 2002Published inissue 1 January 1936https://pubs.acs.org/doi/10.1021/ja01292a027https://doi.org/10.1021/ja01292a027research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct observation of the topological charge of a terahertz vortex beam generated by a Tsurupica spiral phase plate (2014)

A terahertz (THz) spiral phase plate with high transmission (&amp;gt;90% after Fresnel correction) and low dispersion has been developed based on the Tsurupica olefin polymer. Direct observations of the topological charge (both magnitude and sign) of a THz vortex beam are performed by using a THz camera with tilted lens focusing and radial defect introduction. The vortex outputs with a topological charge of ±1 (or ±2) are obtained at a frequency of 2 (or 4) THz.
SUMO Fusion Technology for Enhanced Protein Expression and Purification in Prokaryotes and Eukaryotes (2010)

The preparation of sufficient amounts of high-quality protein samples is the major bottleneck for structural proteomics. The use of recombinant proteins has increased significantly during the past decades. The most commonly used host, Escherichia coli, presents many challenges including protein misfolding, protein degradation, and low solubility. A novel SUMO fusion technology appears to enhance protein expression and solubility ( http://www.lifesensors.com ). Efficient removal of the SUMO tag by SUMO protease in vitro facilitates the generation of target protein with a native N-terminus. In addition to its physiological relevance in eukaryotes, SUMO can be used as a powerful biotechnology tool for enhanced functional protein expression in prokaryotes and eukaryotes.
Prognostic factors in gliomas. A multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic, and molecular markers (1994)

This investigation provides further evidence that flow cytometry, cytogenetic, and molecular genetic factors that may have prognostic value in patients with gliomas can be identified.
Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2 (2010)

GluR2 is a subunit of the AMPA receptor, and the adenosine for the Q/R site of its pre-mRNA is converted to inosine (A-to-I conversion) by the enzyme called adenosine deaminase acting on RNA 2 (ADAR2). Failure of A-to-I conversion at this site affects multiple AMPA receptor properties, including the Ca(2+) permeability of the receptor-coupled ion channel, thereby inducing fatal epilepsy in mice (Brusa et al., 1995; Feldmeyer et al., 1999). In addition, inefficient GluR2 Q/R site editing is a disease-specific molecular dysfunction found in the motor neurons of sporadic amyotrophic lateral sclerosis (ALS) patients (Kawahara et al., 2004). Here, we generated genetically modified mice (designated as AR2) in which the ADAR2 gene was conditionally targeted in motor neurons using the Cre/loxP system. These AR2 mice showed a decline in motor function commensurate with the slow death of ADAR2-deficient motor neurons in the spinal cord and cranial motor nerve nuclei. Notably, neurons in nuclei of oculomotor nerves, which often escape degeneration in ALS, were not decreased in number despite a significant decrease in GluR2 Q/R site editing. All cellular and phenotypic changes in AR2 mice were prevented when the mice carried endogenous GluR2 alleles engineered to express edited GluR2 without ADAR2 activity (Higuchi et al., 2000). Thus, loss of ADAR2 activity causes AMPA receptor-mediated death of motor neurons.
Synthetic substrates for human factor VIIa and factor VIIa-tissue factor (1993)

A series of 100 tripeptide fluorogenic substrates has been synthesized. These substrates contain Arg in the P1 position, various amino acids in the P2 and P3 positions, and different 6-amino-1-naphthalenesulfonamides (ANSN) as the detecting group (P'). The 38 compounds possessing the highest initial rates of factor VIIa hydrolysis were evaluated for substrate kinetic parameters in the presence and absence of tissue factor (TF) and by factor Xa. Most of these substrates had a higher kcat/KM (keff) value for the factor VIIa-TF complex than for factor Xa. Substitution of different amino acids in the P2 position showed that substrates with bulkier amino acids such as Leu, Pro, and Val have higher values for KM and kcat than those with smaller amino acids (Gly or Ser). The highest second-order rate constants were found for substrates with Val or Pro in the P2 position. A decrease or increase in volume of the P2 substituent (Gly, Ser, or Leu) resulted in a decrease in this constant. Substrates with the highest keff values have Phe in the P3 position. As the hydrophobicity and volume of the amino acid in the P3 position decreased, the keff was reduced. The efficiency of substrates for hydrolysis by factor VIIa was enhanced by an increase of hydrophobicity in the P' structure. TF enhanced the amidolytic activity of the "family" of 38 substrates with ANSN in the P' position on an average of 58-fold.
Sharp acoustic multipolar-resonances in highly monodisperse emulsions (2012)

We report the achievement of highly monodisperse emulsions exhibiting about ten acoustic Mie resonances. Thanks to robotics, the effective acoustic properties of such strongly scattering media can be precisely targeted by means of the production of calibrated (random) liquid-droplets. Ultrasonic experiments are compared, with an excellent quantitative agreement, to theoretical predictions derived within the framework of the independent scattering approximation. The dependence of the sound speed and of the acoustic attenuation on both the size and the volume fraction of droplets is quantitatively examined for dilute and more concentrated emulsions, and is presented in a dimensionless way.
Configurable CMOS H-tree logic module (2009)

Configurable logic blocks and programmable interconnections realize configurable computing. This paper proposes a configurable CMOS H-tree logic module. The module consists of a front-end, local programmable mesh and a CMOS H-tree circuit. The small, local mesh is used for 4-variable inverted input signals. The 18-transistor (9P9N) CMOS H-tree logic module could build two-input universal functions, and several frequently used three-input and four-input functions. Furthermore, the small configurable module via a feedback loop could construct a D-latch without any additional buffer. The proposed fine-grained logic module provides excellent design flexibility and functionality for configurable computing.
Observation of two-photon absorption at low power levels using tapered optical fibers and rubidium vapor (2010)

Nonlinear optical effects can be enhanced in tapered fibers with sub-wavelength diameters. Here we report on the observation of two-photon absorption using tapered fibers in rubidium vapor at power levels of less than 150 nW.
Character Recognition by Digital Computer using a Special Flying-Spot Scanner (1961)

A method has already been described for the recognition of spatial patterns by digital computer (Grimsdale et al., 1959). This paper describes how the process can be simplified and speeded up by the use of a flying-spot scanner with special coding facilities.
Towards Scalable and Ubiquitous Millimeter-Wave Wireless Networks (2018)

Millimeter-wave (mmWave) technology is emerging as the most promising solution to meet the multi-fold demand increase for mobile data. Very short wavelength, high directionality, together with sensitivity to rampant blockages and mobility, however, render state-of-the-art mmWave technologies unsuitable for ubiquitous wireless coverage. In this work, we design and implement UbiG - a mmWave wireless access network - that can deliver ubiquitous gigabits per second wireless access consistently to the commercial-off-the-shelf IEEE 802.11ad devices. UbiG has two key design components: (1) a fast probing based beam alignment algorithm that can identify the best beam consistently with guaranteed latency in a mmWave link, and the algorithm scales well even with a very large number of beams; and (2) an infrastructure-side predictive ranking based fast access point switching algorithm to ensure seamless gigabits per second connectivity under mobility and blockage in a dense mmWave deployment. Our IEEE 802.11ad testbed experiments show that UbiG performs close to an "Oracle" solution that instantaneously knows the best beam and access point for gigabits per second data transmission to users.