gebhart/patrepeval huggingface dataset:
Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation, (2014)

This review article focuses on a critical survey of the main available information on the UVB and UVA oxidative reactions to cellular DNA as the result of direct interactions of UV photons, photosensitized pathways and biochemical responses including inflammation and bystander effects. UVA radiation appears to be much more efficient than UVB in inducing oxidatively generated damage to the bases and 2-deoxyribose moieties of DNA in isolated cells and skin. The UVA-induced generation of 8-oxo-7,8-dihydroguanine is mostly rationalized in terms of selective guanine oxidation by singlet oxygen generated through type II photosensitization mechanism. In addition, hydroxyl radical whose formation may be accounted for by metal-catalyzed Haber-Weiss reactions subsequent to the initial generation of superoxide anion radical contributes in a minor way to the DNA degradation. This leads to the formation of both oxidized purine and pyrimidine bases together with DNA single-strand breaks at the exclusion, however, of direct double-strand breaks. No evidence has been provided so far for the implication of delayed oxidative degradation pathways of cellular DNA. In that respect putative characteristic UVA-induced DNA damage could include single and more complex lesions arising from one-electron oxidation of the guanine base together with aldehyde adducts to amino-substituted nucleobases.
Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment (2008)

By being pH sensitive, Systane adapts its viscosity to the ocular surface pH, which tends to be higher in dry eye. It becomes more viscous when the eye is drier, thus, providing better ocular surface protection. In addition, its characteristics reduce ocular surface friction, which is another factor that exacerbates dry eye symptoms. Data published so far show that it is also well tolerated by the patient, thus, significantly reducing dry eye symptoms and improving the patient's quality of life. By implementing this novel approach, Systane has contributed significantly to dry eye treatment.
Distribution and Translocation of Selenium from Soil to Grain and Its Speciation in Paddy Rice (Oryza sativa L.) (2010)

Selenium, an essential micronutrient for humans, is insufficient in dietary intake for millions of people worldwide. Rice as the most popular staple food in the world is one of the dominant selenium (Se) sources for people. The distribution and translocation of Se from soil to grain were investigated in a Se-rich environment in this study. The Se levels in soils ranged widely from 0.5 to 47.7 mg kg(-1). Selenium concentration in rice bran was 1.94 times higher than that in corresponding polished rice. The total Se concentrations in the rice fractions were in the following order: straw>bran>whole grain>polished rice>husk. Significant linear relationships between different rice fractions were observed with each other, and Se in the soil has a linear relationship with different rice fractions as well. Se concentration in rice can easily be predicted by soil Se concentrations or any rice fractions and vice versa according to their linear relationships. In all rice samples for Se speciation, SeMet was the major Se species, followed by MeSeCys and SeCys. The average percentage for SeMet (82.9%) and MeSeCys (6.2%) was similar in the range of total Se from 2.2 to 8.4 mg kg(-1) tested. The percentage of SeCys decreased from 6.3 to 2.8%, although its concentration elevated with the increase in total Se in rice. This could be due to the fact that SeCys is the precursor for the formation of other organic Se compounds. The information obtained may have considerable significance for assessing translocation and accumulation of Se in plant.
809. Aromatic alkylation. Part V. Alkylation by aliphatic alcohols in aqueous perchloric acid (1962)

V. Gold and T. Riley, J. Chem. Soc., 1962, 4183 DOI: 10.1039/JR9620004183
Porous organic–inorganic hybrid xerogels for stearic acid shape-stabilized phase change materials (2017)

The high surface area, porosity and gel properties of MOG-100 (Cr) ensure the excellent thermal properties of SA@MOG-100 (Cr) composites.
Sporobacter (2015)

Abstract Spo.ro.bac'ter. Gr. n. spora a spore; N.L. n. bacter masc. equivalent of Gr. neut. dim. n. bakterion rod; N.L. masc. n. Sporobacter a spore‐forming rod. Slightly curved rods that are 0.2–0.4 × 1–2 µm and occur singly or in pairs. Motile by peritrichous flagella . Gram‐stain‐positive. Terminal spore swelling the sporange. Chemo‐organotrophic and obligately anaerobic member of the domain Bacteria . Yeast extract (0.01%) is required for growth. Produces methylated sulfides from methylated aromatic compounds (e.g., 3,4,5‐trimethoxycinnamate) if sulfide or cysteine is present in the medium with acetate being the only volatile fatty acid produced from this metabolism. External electron acceptors are not used. Mesophilic and neutrophilic . DNA G + C content ( mol %): 57 (HPLC). Type species : Sporobacter termitidis Grech‐Mora, Fardeau, Patel, Ollivier, Rimbault, Prensier, Garcia and Garnier‐Sillam 1996, 517 VP . Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the genus Sporobacter is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Bacillati / Bacillota / Clostridia / Eubacteriales / Oscillospiraceae / Sporobacter The genus Sporobacter can also be recovered in the Genome Taxonomy Database (GTDB) as g__Sporobacter (version v220) ** . GTDB classification: d__Bacteria / p__Bacillota_A / c__Clostridia / o__Oscillospirales / f__Oscillospiraceae / g__Sporobacter * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
CT volumetric data-based left ventricle motion estimation: an integrated approach (1995)

This paper describes a novel approach to left ventricle motion analysis via the integration of image segmentation with shape deformation analysis using computerized tomography (CT) volumetric image data. This approach is different from traditional image analysis scenario in which the image segmentation and shape analysis were considered separately. The advantage of integrating the image segmentation with the shape analysis lies in the fact that the shape characteristics of the object can be used as effective constraints in the process of segmentation while original image data can be made useful along with the segmentation results in the process of shape analysis. In the case of left ventricle motion estimation, such an integration can be applied to obtain the estimation results that are consistent with both given image data and a priori shape knowledge. The initial segmentation of the images is obtained through adaptive K-mean classification and the region-of-interest is then identified based on the initial segmentation. The shape analysis is accomplished through fitting the boundary points of the region-of-interest to the surface modeling primitives. These two processes are integrated through the feedforward and feedback channels so that the surface fitting is constrained by the confidence measures of the boundary points and segmentation refinement is guided by the result of surface modeling. Global motion parameters are obtained by comparing the parameters of the fitted surface model at consecutive time instances. The segmentation and shape analysis results obtained show that the integrated approach is capable of providing promising improvement over traditional approaches.
Peptide Receptor Radionuclide Therapy in a Case of Multiple Spinal Canal and Cranial Paragangliomas (2010)

Multiple spinal and subtentorial intradural paragangliomas were detected in a surgically-treated cauda equina tumor, though it was not clear whether the masses were genuine metastases or an unknown “metachronous paraganglial syndrome”. Either way, the therapeutic options were few. Histology, immunohistochemistry, genetics and advanced molecular imaging were performed to further analyze the lesions and find an effective therapy. Given the high density of somatostatin receptors in the tumors, the patient underwent peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]-Octreotate. Follow-up MRI and 68Ga-DOTANOC PET/CT demonstrated very promising outcomes in terms of volume reduction (mean 69.9%±13%) and maximum standardized uptake value reduction (mean 84.8%±13.3%).
Off-Resonance Low-Pressure Operation of Lorentz Force MEMS Magnetometers (2014)

This paper demonstrates bandwidth extension for Lorentz force microelectromechanical systems magnetometers operated at a frequency slightly lower than the mechanical resonance. This off-resonance mode of operation also minimizes the critical tradeoff between maximum sensing bandwidth and minimum measurable field, enabling low-pressure operation and the associated resolution improvement. The experimental verification is obtained using two identical devices packaged at two different pressures and tested with a suitable low-noise board-level electronics. The first device, packaged at 1 mbar, has a (mechanical) sensing bandwidth of ~50 Hz, and a resolution per unit bandwidth and driving current of 290 nT · mA/√Hz. With the second device, packaged at 0.25 mbar and operated off-resonance, roughly twice better resolution (160 nT · mA/√Hz) and four times larger bandwidth (>200 Hz) are obtained.
Microbiological alteration of the transport behaviour of redoxsensitive radionuclides in sediments (2021)

The influence of microbial activity on the migration behaviour of redoxsensitive radionu-clides Technetium (Tc) and Selenium (Se) in groundwater environments was investigated within an interdisciplinary research program. Soil material (contaminated with allochthonous microorganisms) and tertiary sediments (sterile sampling, indigenous bacteria population) were investigated using recirculation columns. The mobility of redoxsensitive radionuclides in soils and sediments are effected by several abiotic and biotic parameters. Besides the abiotic factors microorganisms interact with Tc and Se by adsorption, reduction/oxidation, incorporation and complexation processes. Sorption experiments with pure bacteria cultures were carried out to understand the immobilization mechanisms. The sorption experiments with the non sterile surface material showed a high immobilization of both radionuclides. The addition of a biocide to avoid further microbial activities was followed by a slow release of Tc and Se into the recirculating water. In the identical, but sterilized material no significant fixation occurred. An addition of a mixed bacteria culture (inoculum) resulted in strong decrease of the radionuclide concentration in the water. The redox potential has always been above +300 mV. The Tc sorption experiments with bacteria cultures without sediments a high immobilization was measured only after the addition of a reducing(SnCl2) agent. Without SnCl2 addition no immobilization occurred. These investigations indicate that the microbial influence on the immobilization is due to a metabolic decrease of the redox potential in micro pores of the sediment and a subsequent adsorption to cell structures Neglectiing the microbial activities and micro-environments in nature as well as under laboratory conditions, may lead to a wrong assessment of the migration behavior of hazardous elements.
Palladium‐Catalyzed Alkoxycarbonylation of Conjugated Dienes under Acid‐Free Conditions: Atom‐Economic Synthesis of β,γ‐Unsaturated Esters (2014)

Carbonylation reactions constitute important methodologies for the synthesis of all kinds of carboxylic acid derivatives. The development of novel and better catalysts for these transformations is of interest for both academic and industrial research. Here, a benign palladium-based catalyst system for the alkoxycarbonylation of conjugated dienes under acid-free conditions has been developed. This atom-efficient transformation provides straightforward access to a variety of β,γ-unsaturated esters in good to excellent yields and often with high selectivities. As an industrially relevant example the (formal) synthesis of dimethyl adipate and ε-caprolactam from 1,3-butadiene is demonstrated.
Integrated Selective Heart Disease Screening (2005)

Integrated selective heart disease screening is based on the concept of selective screening procedures, passing through one sieve to the next as a result of a high score in risk factor assessment. Coarse sieves at the start of the system are based on simple, low cost techniques (e.g. age), but are, nevertheless, most effective at screening out large numbers of people with extremely low probabilities of having the disease.
CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation (2002)

The mammalian centrosome consists of a pair of centrioles surrounded by pericentriolar material (PCM). The architecture and composition of the centrosome, especially the PCM, changes during the cell cycle. Recently, a subset of PCM proteins have been shown to be arranged in a tubular conformation with an open and a closed end within the centrosome. The presence of such a specific configuration can be used as a landmark for mapping proteins in both a spatial and a temporal fashion. Such mapping studies can provide information about centrosome organization, protein dynamics, protein-protein interactions as well as protein function. In this study, the centrosomal proteins CEP110 and ninein were mapped in relationship to the tubular configuration. Both proteins were found to exhibit a similar distribution pattern. In the mother centrosome, they were found at both ends of the centrosome tube, including the site of centrosome duplication. However, in the daughter centrosome they were present only at the closed end. At the closed end of the mother and daughter centrosome tube, both CEP110 and ninein co-localized with the centriolar protein CEP250/c-Nap1, which confirms ninein's centriole association and places CEP110 in association with this structure. Importantly, the appearance of CEP110 and ninein at the open end of the daughter centrosome occurred during the telophase-G1 transition of the next cell cycle, concomitant with the maturation of the daughter centrosome into a mother centrosome. Microinjection of antibodies against either CEP110 or ninein into metaphase HeLa cells disrupted the reformation of the tubular conformation of proteins within the centrosome following cell division and consequently led to dispersal of centrosomal material throughout the cytosol. Further, microinjection of antibodies to either CEP110 or ninein into metaphase PtK2 cells not only disrupted the tubular configuration within the centrosome but also affected the centrosome's ability to function as a microtubule organizing center (MTOC). This MTOC function was also disrupted when the antibodies were injected into postmitotic cells. Taken together, our results indicate that: (1) a population of CEP110 and ninein is located in a specific domain within the centrosome, which corresponds to the open end of the centrosome tube and is the site of protein addition associated with maturation of a daughter centrosome into a mother centrosome; and (2) the addition of CEP110 and ninein are essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC.
Mechanical Fragility Calibration of Red Blood Cells (2005)

Mechanical fragility of red blood cells (RBCs) is a critical variable for the hemolysis testing of many important clinical devices, such as pumps, valves, and cannulae, and gas exchange devices. Unfortunately, no standardized test for RBC mechanical fragility is currently well accepted. Although many test devices have been proposed for the study of mechanical fragility of RBCs, no one has ever shown that their results have any relevance to a blood pump. Therefore, the fundamental objective of this study was to determine if one or more test devices could be validated as calibrators to document the fragility of the test blood used for any particular test blood. We compared five mechanical fragility test systems to each other and to a Biopump, with respect to hemolysis. All five devices seem to measure the same parameter; the hemoresistometer most closely matched the pump test results, but the stainless steel bead test may be the most practical for routine calibration purposes.
Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes (2005)

Various incubation conditions of human hepatocytes were compared for their accuracy in predicting the in vivo hepatic clearance (CLH) of model compounds. The test compounds were the highly cleared, low protein bound naloxone (in vivo CLH = 25 ml min−1 kg−1; free fraction = 0.6), the medium clearance, highly protein bound midazolam (CLH = 12 ml min−1 kg−1; free fraction = 0.04) and the low clearance, highly protein bound bosentan (CLH = 3.9 ml min−1 kg−1; free fraction = 0.02). Each compound was tested in three ‘hepatocyte systems’, using resections from three donors, in the presence and absence of human serum. Those hepatocyte systems were: conventional primary cultures, freshly isolated suspensions and cryopreserved suspended hepatocytes. Except for a twofold overestimated CLH for bosentan from conventional primary cultures, and despite variable cryopreservation recoveries, similar predictions of CLH were recorded with all hepatocyte systems. Moreover, the CLH values obtained with cryopreserved suspended hepatocytes were similar to those obtained with freshly isolated suspensions. For midazolam and bosentan, the predicted in vivo CLH was markedly higher in the presence of serum, whereas serum had little influence on the scaled-up CLH of naloxone. In vivo, CLH was properly approached for naloxone and bosentan (particularly from experiments in the presence of serum), but it was strongly underestimated for midazolam (particularly in the absence of serum). Additional compounds need to be investigated to confirm the above findings as well as to assess why the clearances of some highly protein-bound compounds are still considerably underestimated.
The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2 Nanotube in Rats (2015)

With the development of nanotechnology, many researches have shown that nanometer‐scaled materials especially TiO 2 nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegration in vivo . The aim of this study was to evaluate the effect of implant surface‐treated with different size of TiO 2 nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface‐treated with different diameter of TiO 2 nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague‐Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO 2 nanotube size may influence new bone formation and osseointegration in rats.
A WBEM based disk array management provider (2005)

As an enterprise resources management standard, WBEM (Web based enterprise management) has been applied in many fields. In this paper, we introduce its application in storage management - SMI-S, which developed by SNIA and been wildly accepted by storage manufactures and end-users. We mainly focus on how to apply WBEM/SMI-S on developing a disk array provider. To make the legacy disk arrays management interface SMI-S compliant without significant reengineering, we design a proxy device interface to map our proprietary data model to SMI-S, and the provider supports the instance enumeration, association, method call, indication. The provider implements the required sub-profiles of the array' profile defined in the SMI-S 1.0.2. It has successfully passed SNIA-conformance test program (SNIA-CTP) test that indicates its conformance to SMI-S well.
Copper metallization of low-dielectric-constant a-SiCOF films for ULSI interconnects (2001)

The interactions between magnetron-sputtered Cu and plasma-enhanced chemical-vapour-deposited a-SiCOF film have been investigated via x-ray photoelectron spectroscopy (XPS), Auger electron spectroscopy (AES) and scanning electron microscopy (SEM). High-resolution C 1s, Cu 2p, O 1s, Si 2p and F 1s XPS spectra for the samples before and after annealing are collected. The results show that the C-Cu bond is not observed at the interface of Cu/a-SiCOF before or after the annealing. Moreover, the annealing causes the obvious shifts of Cu 2p3/2, C 1s, O 1s and Si 2p photoelectron peaks toward higher binding energy, and the underlying reasons are discussed in detail. The AES spectra of Cu L3M4,5M4,5 with the etching time reveal that some chemical reactions take place at the interface during the sputtering deposition of copper on the a-SiCOF film, and possible reaction mechanisms are also presented. The Cu 2p3/2 XPS spectra and the SEM graphs demonstrate that the annealing enhances the interdiffusion between Cu and a-SiCOF film.
Ketoconazole treatment in Cushing's syndrome: experience in 34 patients (1991)

These data confirm that ketoconazole is valuable in the management of hypercortisolism, provided that patients are closely watched to exclude those who may develop liver toxicity and to prevent the occurrence of adrenal insufficiency.
Enhanced bioactivity of MMP-truncated CXCL8 <i>in vitro</i> and <i>in vivo.</i> (2015)

&lt;p&gt;(A) Ca&lt;sup&gt;++&lt;/sup&gt; ion mobilization with 10 nM CXCL8 and (B) chemotaxis of CXCR2-transfected B300-19 cells stimulated with 10 nM full-length CXCL8 (1-77) and CXCL8 (6-77) synthetic analogue of MMP-8-cleaved CXCL8. (C) Time course of air pouch PMN influx in response to CXCL8 (1-77) and CXCL8 (6-77) in &lt;i&gt;Mmp8&lt;/i&gt;-/- mice (black) and wild type (white) mice as quantitated by myeloperoxidase assay.&lt;/p&gt;
Intra Mode Decision Based on Spatio-Temporal Cues in Pixel Domain Wyner-ZIV Video Coding (2006)

Distributed source coding principles have been recently applied to video coding in order to achieve a flexible distribution of the complexity burden between the encoder and the decoder. In this paper we elaborate on a pixel based Wyner-Ziv video codec that shifts all the complexity of the motion estimation phase to the decoder, thus achieving light encoding. We observe that the correlation noise statistics describing the relationship between the frame to be encoded and the side information available at the decoder is not spatially stationary. For this reason we introduce a mode decision scheme either at the encoder or at the decoder in such a way that when the estimated correlation is weak we opt for intra coding on a block-by-block basis. Both spatial and temporal criteria are used to determine whether a block is better intra coded or not