gebhart/patrepeval huggingface dataset:
LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells (2019)

Glioblastoma (GBM) is the most frequent malignant brain tumor. It represents the most aggressive astrocytoma with an overall survival of 14 months. Despite improvements in surgery techniques, radio‑ and chemotherapy, most patients present treatment resistance, recurrence and disease progression. Therefore, development of effective alternative therapies is essential to overcome treatment failure. The purpose of the study was to evaluate the antitumoral activity of the synthetic compound LQB‑118, in vitro. Monolayer and three‑dimensional (3D) cell culture systems of human‑derived GBM cell lines were used to evaluate the effect of LQB‑118 on cell viability, cell death and migration. LQB‑118 reduced cell viability as determined by MTT and trypan blue exclusion assays and promoted apoptosis in monolayer cell lines with an intrinsic temozolomide (TMZ)‑resistance profile. In 3D culture models, LQB‑118 reduced cell viability as evaluated by APH assay and inhibited cell migration while the TMZ resistance profile was maintained. Moreover, LQB‑118 reduced p38 and AKT expression and phosphorylation, whereas it reduced only the phosphorylated ERK1/2 form. LQB‑118 reduced p38 and NRF2 expression, an axis that is associated with TMZ resistance, revealing a mechanism to overcome resistance. LQB‑118 also demonstrated an additional effect when combined with ionizing radiation and cisplatin. In conclusion, the present data demonstrated that LQB‑118 maintained its effectiveness in a 3D cell conformation, which shares more similarities with the tumor mass. LQB‑118 is a promising agent for GBM treatment as monotherapy and associated with radiotherapy or cisplatin. Its effect is associated with inhibition of GBM‑related survival signaling pathways.
Design of a New Cascade Reaction for the Construction of Complex Acyclic Architecture:  The Tandem Acyl-Claisen Rearrangement (2001)

Tandem or domino reactions have long been established as powerful chemical tools for the rapid formation of complex cyclic and polycyclic architecture. Surprisingly, however, relatively few tandem strategies have been directed toward the production of acyclic structural motifs despite significant advances in the area of acyclic stereocontrol. In our recent study, we reported the development of the acyl-Claisen rearrangement, a catalytic [3,3]-bond reorganization that allows the stereoselective synthesis of α,β-disubstituted-γ,δ-unsaturated carbonyls. In this communication, we outline the development of the tandem acyl-Claisen reaction, a highly stereoselective three-component coupling that enables the rapid construction of complex acyclic systems in the context of 2,3,6-trisubstituted-1,7-dioxoheptane architecture (eq 1). This versatile cascade sequence is conducted by using simple allyl diamines and acid chlorides, chemicals that are widely available in a diverse range of structural formats. As such, we expect this tandem reaction to be of broad utility to a number of chemical fields that employ molecule construction including natural product and parallel medicinal agent synthesis.
An Eight-Channel Phased Array RF Coil for Spine MR Imaging at 7 T (2009)

These early results indicate that a multichannel transmit/receive phased array RF coil can be used for in vivo spine imaging at 7 T, thereby rendering high-resolution spine imaging a promising new application in 7 T clinical research.
Structure and electrical properties of (0.965 − x)(K0.48Na0.52)NbO3–xBiGaO3–0.035(Bi0.5Na0.5)ZrO3 piezoelectric ceramics (2016)

(0.965 − <italic>x</italic>)(K<sub>0.48</sub>Na<sub>0.52</sub>)NbO<sub>3</sub>–<italic>x</italic>BiGaO<sub>3</sub>–0.035(Bi<sub>0.5</sub>Na<sub>0.5</sub>)ZrO<sub>3</sub> [(0.965 − <italic>x</italic>)KNN–<italic>x</italic>BG–BNZ] lead-free piezoelectric ceramics were prepared using normal sintering for improving the piezoelectric properties and temperature stability of KNN-based ceramics.
Received power and ambient electric field from broadband emissions in reverberant spaces (2015)

The electromagnetic environment created in a reverberant space by broadband RF emissions is investigated. A white Gaussian noise source is used to emulate the wide power spectral density bandwidth, low temporal coherence time (rapid signal fluctuations), and large peak-to-average power ratio characteristics of emissions from modern digitally modulated spread-spectrum wireless networks. The interaction between the wide power spectral density of the noise signal and the highly frequency-selective channel of the reverberant space leads to average received power and average ambient electric field that exhibit very small spatial variation in the volume. This spatial uniformity in average field results from integration of the received signal power spectral density across the wide frequency bandwidth. The peak-to-average power ratio (PAPR) is derived from the time-dependent power waveform statistics of the received signal. A maximum electric field is computed from the peak received power.
Torque analysis of permanent magnet coupling using 2D and 3D finite elements methods (1989)

The design and analysis of a radial-type permanent-magnet coupling in aerospace drives using the 2D and 3D finite-element (FE) methods is discussed. The analytical results are obtained using Maxwell stress and virtual-work methods. Correlation of the analytical and test results show that the accuracy of 2D FE analysis deteriorates when significant end leakage is present due to a large airgap or small length-to-diameter ratio. The 3D FE analysis takes the end effects into account and eliminates that error.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Simultaneous Occurrence of Sarcoidosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis in a Patient with Lung Cancer (2019)

A 71-year-old woman with abnormal pulmonary shadows and multiple enlarged thoracic lymph nodes was diagnosed with stage IIB lung adenocarcinoma, pulmonary sarcoidosis, and sarcoidosis-associated lymphadenopathy after biopsies from multiple organ sites. She also had rapidly progressive renal dysfunction, microhematuria, and high myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) concentrations. A renal biopsy revealed granulomatous tubulointerstitial nephritis and necrotizing glomerulonephritis with crescent formation. She was diagnosed with nephritis caused by both sarcoidosis and ANCA-associated vasculitis. Oral prednisolone was administered to treat her nephritis, resulting in improvement in both her renal dysfunction and her sarcoidosis-associated lymphadenopathy.
A simple atomic force microscopy method for the visualization of polar and non-polar parts in thin organic films (2006)

Here we present a scanning probe microscopy method that allows for the identification of regions of different polarity (i.e. hydrophilicity) in thin organic films. This technique is based on the analysis of the difference between phase images generated at different applied bias voltages in tapping-mode atomic force microscopy. We show that, without any chemical modification of the microscope tip, it is possible to investigate surface properties of complex macromolecular layers, yielding new insight into the functional properties of the photosynthetic electron transport macromolecular complex,Photosystem I.
Geometric symmetry breaking and nonlinearity can increase thermoelectric power (2023)

Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. By increasing the FF one can potentially increase maximum power by up to four times, but this is only possible in the nonlinear regime of transport and has previously rarely been considered. Here we show, based on fundamental symmetry considerations, that the leading order non-linear terms that can increase the FF require devices with broken spatial symmetry. To experimentally demonstrate such a system, we study nonlinear, thermoelectric transport across an asymmetric energy barrier epitaxially defined in a single semiconductor nanowire. We find in both experiment and theory that we can increase the FF above the linear-response limit of 0.25, accompanied by a drastic increase in short circuit current, open-circuit voltage and maximum power. Our results show that geometric symmetry breaking combined with the design of nonlinear behaviour represent a design strategy for increasing the performance of thermal-to-electric energy converters such as in hot-carrier photovoltaics, thermophotovoltaics or in anisotropic thermoelectric materials.
ChemInform Abstract: Novel Antioxidants: Unexpected Rearrangements in the Radical Cyclization Approach to 2,3‐Dihydrobenzo[b]thiophene‐5‐ol Derivatives. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activation and potentiation of the NO/cGMP pathway by NG‐hydroxyl‐L‐arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing (2003)

1 When nitric oxide synthase (NOS) produces NO from N(G)-hydroxy-L-arginine (OH-arginine) instead of L-arginine, the total requirement of molecular oxygen and NADPH to form NO is reduced. The aim of this work was to evaluate the effects of OH-arginine on the contractility of rabbit corpus cavernosum (RCC) and to compare the capacities of L-arginine and OH-arginine to enhance NO-mediated responses under normoxic and hypoxic conditions and in ageing, as models of defective NO production. 2 OH-arginine, but not L-arginine, was able to relax phenylephrine-contracted rabbit trabecular smooth muscle. OH-arginine-induced relaxation was inhibited by the NOS-inhibitor, L-NNA (300 microM), and by the guanylyl cyclase inhibitor, ODQ (20 microM), while it was not affected by the cytochrome P450 oxygenase inhibitor, miconazole (0.1 mM). Administration of OH-arginine, but not L-arginine, produced a significant increment of cGMP accumulation in RCC tissue. 3 Relaxation elicited by OH-arginine (300 microM) was still observed at low oxygen tension. The increase of cGMP levels induced by ACh (30 microM) in RCC was significantly enhanced by addition of OH-arginine (300 microM) in normoxic conditions, as well as under hypoxia, while L-arginine did not alter the effects of ACh on cGMP accumulation. 4 Endothelium-dependent and nitrergic nerve-mediated relaxations were both significantly reduced in RCC from aged animals (>20-months-old) when compared with young adult rabbits (5-months-old). Treatment with OH-arginine (300 microM) significantly potentiated endothelium-dependent and neurogenic relaxation in corpus cavernosum from aged rabbits, while L-arginine (300 microM) did not have significant effects. 5 Results show that OH-arginine promotes NO-mediated relaxation of RCC and potentiates the NO-mediated responses induced by stimulation of endogenous NO generation in hypoxic and aged tissues. We propose that the use of OH-arginine could be of interest in the treatment of erectile dysfunction, at least in those secondary to defective NO production.
A small protein from the bop–brp intergenic region of Halobacterium salinarum contains a zinc finger motif and regulates bop and crtB1 transcription (2008)

Bacteriorhodopsin, the photosynthetic protein of Halobacterium salinarum, is optimally expressed under anaerobic growth conditions. We identified Brz (OE3104F, bacteriorhodopsin-regulating zinc finger protein), a new regulator of the bop gene. It is a small protein with a zinc finger motif, encoded directly upstream of the bop gene in the same orientation. Deletion of the brz gene caused a large decrease of bop mRNA levels as shown by Northern blot and microarray analysis. A similar effect was obtained by site-directed mutagenesis of Cys and His residues in the zinc finger motif, indicating the importance of this motif for the function of the protein. In silico analysis of the genomes from H. salinarum and other archaea revealed a large family of similar small zinc finger motif proteins, some of which may also be involved in transcription regulation of their adjacent genes.
Aluminum in Wine - Its Measurement and Identification of Major Sources (1992)

Aluminum levels in wine were found generally to fall below the normal working range of flame atomic absorption spectrometry and above the linear working range for graphite furnace atomic absorption spectrometry. Graphite furnace atomic absorption spectrometry was selected as the preferred method. The analytical procedure requires the dilution of the sample to reduce the aluminum concentration to within the linear working range, and this was shown to have the advantage of overcoming matrix effects on the analysis. From a survey of 267 wines, it was shown that white wines and sparkling wines have a slightly higher mean aluminum concentration than red wines or fortified wines. From a study of juices and wines at various stages of winemaking, it was observed that the addition of bentonite was a major source of aluminum contamination, with increases of 100% common after bentonite treatment. Other sources of aluminum which were identified were contact with the metal, pad filtration, and red tannin.
Effect of correlating adjacent neurons for identifying communications: Feasibility experiment in a cultured neuronal network (2017)

Neuronal networks have fluctuating characteristics, unlike the stable characteristics seen in computers. The underlying mechanisms that drive reliable communication among neuronal networks and their ability to perform intelligible tasks remain unknown. Recently, in an attempt to resolve this issue, we showed that stimulated neurons communicate <i>via</i> spikes that propagate temporally, in the form of spike trains. We named this phenomenon "<i>spike wave propagation</i>". In these previous studies, using neural networks cultured from rat hippocampal neurons, we found that multiple neurons, <i>e.g.</i>, 3 neurons, correlate to identify various spike wave propagations in a cultured neuronal network. Specifically, the number of <i>classifiable neurons</i> in the neuronal network increased through correlation of spike trains between current and adjacent neurons. Although we previously obtained similar findings through stimulation, here we report these observations on a physiological level. Considering that individual spike wave propagation corresponds to individual communication, a correlation between some adjacent neurons to improve the quality of communication classification in a neuronal network, similar to a diversity antenna, which is used to improve the quality of communication in artificial data communication systems, is suggested.
High‐resolution, spin‐echo BOLD, and CBF fMRI at 4 and 7 T (2002)

With growing interest in noninvasive mapping of columnar organization and other small functional structures in the brain, achieving high spatial resolution and specificity in fMRI is of critical importance. We implemented a simple method for BOLD and perfusion fMRI with high spatial resolution and specificity. Increased spatial resolution was achieved by selectively exciting a slab of interest along the phase-encoding direction for EPI, resulting in a reduced FOV and number of phase-encoding steps. Improved spatial specificity was achieved by using SE EPI acquisition at high fields, where it is predominantly sensitive to signal changes in the microvasculature. Robust SE BOLD and perfusion fMRI were obtained with a nominal in-plane resolution up to 0.5 x 0.5 mm(2) at 7 and 4 Tesla, and were highly reproducible under repeated measures. This methodology enables high-resolution and high-specificity studies of functional topography in the millimeter to submillimeter spatial scales of the human brain.
Acute and Long-Term Behavioural Effects of MDMA in Adolescent Rats (2011)

Acute MDMA, even at low doses, increases social interaction in adult rats [1] while on the long-term its consumption produces a decrease in social interaction, an increase in anxiety and impaired object recognition memory [2, 3]. This study investigated whether MDMA has the same effects in adolescent rats. Additionally, we investigated whether the preference of adolescent rats for MDMA was mediated by social context.
Process Development and Good Manufacturing Practice Production of a Tyrosinase Inhibitor via Titanium-Mediated Coupling between Unprotected Resorcinols and Ketones (2017)

A concise and economically attractive process for the synthesis of a novel tyrosinase inhibitor has been developed and implemented on a multikilogram scale under GMP. A major achievement to the success of the process is the development of a direct coupling between free resorcinol and ketone. First developed under basic conditions, this coupling has been turned to a novel titanium(IV) mediated process allowing good selectivity, easy isolation, and high atom efficiency. Other key steps feature an alkene reduction by palladium catalyzed transfer hydrogenation and a urea formation using N,N′-disuccinimidyl carbonate as the carbonyl source. This route allowed us to produce kilogram batches of the candidate to support preclinical and clinical studies.
A Novel Transducer for Monitoring Surge Currents in AC Mains: Expectations and Reality | NIST (2000)

The proliferation of surge-protective devices and switch-mode power supplies has radically changed the surge environment in the low-voltage AC mains. Monitoring surge voltages has lost significance and can be misleading. Instead, surge currents should be monitored. The paper describes the performance of a silicon-based surge-protective device acting as a magnet for impinging surges in the presence of multiple metaloxide varistors. This magnet is the first step toward the development of a transducer producing a voltage signal reflecting the surge current that can be delivered by the power system. That signal can then be applied to the voltage input of existing power quality monitors.
Hydrodynamics of fluidization: superconducteur generated vs. experimental bubbles (1985)

Comparaison des resultats obtenus par le modele bidimensionnel propose par ITT et une etude experimentale menee avec des billes de verre de 50 μm et 800 μm
Optimization Of The Sample Technique For NIR FT Raman Spectroscopy (1989)

Raman spectroscopy is a powerful complement to infrared spectroscopy due to experimental as well as theoretical aspects: However, &apos;classical&apos; Raman spectroscopy is not commonly used. This is mainly due to the fact that the fluorescence of minute amounts of impurities, excited by the radiation in the UV or visible range can mask the Raman spectra completely. NIR FT Raman spectrometers&apos; have several advantages. As exciting light usually the radiation of the Nd-doped YAG laser at a wavelength of 1064 nm is used. Problems with fluorescing samples are largely reduced. There is the &apos;throughput advantage&apos; of the Michelson interferometer and its high wavenumber accuracy. However, the intensity of the Raman radiation is inversely proportional to the fourth power of its absolute frequency. Laser light fluxes larger by the &nu;4-factor of about 30 are necessary to achieve the same radiance of the Raman lines in the NIR compared to the visible region. This enhances the danger of pyrolysis of the sample. In order to reduce this danger the whole instrument should have the largest possible optical conductance. Interferometers are therefore appropriate when they are properly matched to a sample arrangement with maximal efficiency.
DESIGN AND IMPLEMENTATION OF A WIRELESS NETWORK SYSTEM IN A SMART CAMPUS (2007)

Article talks about the design and implementation of wireless network in Engineering Campus of UniversitySains Malaysia. The goals of this research is designing a network which able to bring mobility to all network usersin this campus. In this research, there is a mathematical model which can be used to predict the coverage of theaccess point. Coverage testing had been carried out at library. Based on the original placement of the access pointwhich done by the PPKT, the Universiti Sains Malaysia’s (USM) computer center. Since the result is not so satisfying,a new design based on the characteristic of the access point and the building structure was done.Keywords: wireless network, smart campus, library
Optimizing tertiary storage organization and access for spatio-temporal datasets (1995)

We address in this paper data management techniques for efficiently retrieving requested subsets of large datasets stored on mass storage devices. This problem represents a major bottleneck that can negate the benefits of fast networks, because the time to access a subset from a large dataset stored on a mass storage system is much greater that the time to transmit that subset over a network. This paper focuses on very large spatial and temporal datasets generated by simulation programs in the area of climate modeling, but the techniques developed can be applied to other applications that deal with large multidimensional datasets. The main requirement we have addressed is the efficient access of subsets of information contained within much larger datasets, for the purpose of analysis and. interactive visualization. We have developed data partitioning techniques that partition datasets into ``clusters`` based on analysis of data access patterns and storage device characteristics. The goal is to minimize the number of clusters read from mass storage systems when subsets are requested. We emphasize in this paper proposed enhancements to current storage server protocols to permit control over physical placement of data on storage devices. We also discuss in some detail the aspects of the interface between the application programs and the mass storage system, as well as a workbench to help scientists to design the best reorganization of a dataset for anticipated access patterns.
Highly Mobile Solvent Holes in Viscous Squalane Solutions As Detected by Quantum Beats and MARY Spectroscopy Techniques (1999)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionHighly Mobile Solvent Holes in Viscous Squalane Solutions As Detected by Quantum Beats and MARY Spectroscopy TechniquesOleg M. Usov, Dmitrii V. Stass, Boris M. Tadjikov, and Yuri N. MolinCite this: J. Phys. Chem. A 1999, 103, 11, 1690Publication Date (Web):March 3, 1999Publication History Published online3 March 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/jp984509ghttps://doi.org/10.1021/jp984509gcorrectionACS PublicationsCopyright © 1999 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views200Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 KB) Get e-Alertsclose Get e-Alerts