gebhart/patrepeval huggingface dataset:
TESTICULAR LH BINDING IN THE HAMSTER: MODIFICATION BY PHOTOPERIOD AND PROLACTIN1 (1977)

Suppression of testicular weight and activity induced in the hamster by light deprivation can be partially reversed by treatment with prolactin (PRL). The present study investigates the possibility that the stimulatory effect of PRL in this preparation may be mediated through increased LH binding. Hamsters exposed to 5 h light per day for two months to induce gonadal atrophy were injected daily for 2 1/2 weeks with saline, 250 mug PRLP, 20 MUG LH+150 mug FSH, or PRL+LH+FSH. Short light control animals exhibited significantly less LH binding than controls on 14 h of light per day. Treatment with LH+FSH had no effect on LH binding while PRL alone or in combination with LH+FSH increased binding to levels greater than the long light controls. Peripheral testosterone concentrations reflected the level of LH binding. Scatchard analysis indicates that the decreased binding in the short-day animals is due to reduced LH receptor numbers and that PRL treatment elevates receptor levels thereby increasing LH binding. These results suggest that the mechanism by which PRL stimulates testicular function in hamsters with regressed gonads is through increased binding of endogenously produced LH.
Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care (2019)

Heart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current "one-size-fits-all" approach in the treatment of HF does not result in best outcome for all patients. These facts are an imminent threat to good quality management of patients with HF. An unorthodox approach from a new vision on care is required. We propose a novel predictive, preventive and personalised medicine approach where patients are truly leading their management, supported by an easily accessible online application that takes advantage of artificial intelligence. This strategy paper describes the needs in HF care, the needed paradigm shift and the elements that are required to achieve this shift. Through the inspiring collaboration of clinical and high-tech partners from North-West Europe combining state of the art HF care, artificial intelligence, serious gaming and patient coaching, a virtual doctor is being created. The results are expected to advance and personalise self-care, where standard care tasks are performed by the patients themselves, in principle without involvement of healthcare professionals, the latter being able to focus on complex conditions. This new vision on care will significantly reduce costs per patient while improving outcomes to enable long-term sustainability of top-level HF care.
Author response: Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle (2023)

Microtubule-dependent movement of the glucose transporter GLUT4 is important for insulin-stimulated muscle glucose uptake, involves the motor protein KIF5B, and is impaired in muscle from diet-induced obese mice.
Low-Complexity Widely-Linear Precoding for Downlink Large-Scale MU-MISO\n Systems (2015)

In this letter, we present a widely-linear minimum mean square error\n(WL-MMSE) precoding scheme employing real-valued transmit symbols for downlink\nlarge-scale multi-user multiple-input single-output (MU-MISO) systems. In\ncontrast to the existing WL-MMSE transceivers for single-user multiple-input\nmultiple-output (SU-MIMO) systems, which use both WL precoders and WL\ndetectors, the proposed scheme uses WL precoding only and simple conventional\ndetection at the user terminals (UTs). Moreover, to avoid the computational\ncomplexity associated with inversion of large matrices, we modify the WL-MMSE\nprecoder using polynomial expansion (PE). Our simulation results show that in\noverloaded systems, where the number of UTs is larger than the number of base\nstation antennas, the proposed PE WL-MMSE precoder with only a few terms in the\nmatrix polynomial achieves a substantially higher sum rate than systems\nemploying conventional MMSE precoding. Hence, more UTs sharing the same\ntime/frequency resources can be served in a cell. We validate our simulation\nresults with an analytical expression for the asymptotic sum rate which is\nobtained by using results from random matrix theory.\n
Symbol lock detection in the ARX 2 and Block 5 receivers (1991)

The performances of 5 symbol-lock detectors are compared. These detectors are the square-law detector with overlapping (SQOD) and nonoverlapping integrators, the absolute-value detectors with overlapping and nonoverlapping integrators, and the signal-power estimator detector (SPED). The analysis considers various scenarios in which the observation interval is much larger than or equal to the symbol-synchronizer loop bandwidth, and which were not considered in previous analyses. Also, the case of threshold setting in the absence of signal is considered. It is shown, that the SQOD outperforms all others when the threshold is set in the presence of a signal, independent of the relationship between loop bandwidth and observation period. On the other hand, the SPED outperforms all others when the threshold is set in the presence of noise only.
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 9. Enzymatic joining of chemically synthesized deoxyribopolynucleotide segments corresponding to nucleotide sequence 57-94. (1976)

The DNA duplexes representing nucleotide sequences 61-89 and 57-94 have been synthesized, isolated pure, and fully characterized. Synthesis of the duplex with the nucleotide sequence 61-89 involved the DNA ligase-catalyzed joining of chemically synthesized deoxyoligonucleotide segments 14 to 18 shown in Fig. 1A, while for the longer duplex (sequences 57-94) seven deoxyribooligonucleotides (segments 13 to 19, Fig. 1B) were used in one-step enzymatic joining. The joining of the short tetranucleotide (segment 16) to the segment 17 required the presence of the adjacent segment 14, even if the latter did not contain a 5'-phosphate group, to allow its joining to segment 16. However, in the synthesis of both of the DNA duplexes, the yields were comparatively low (30 to 40%) and could not be significantly increased although a variety of conditions was tried. The main cause in both cases evidently was the sluggish joining of segment 14 to 16 and of segment 16 to segment 17. Although the original plan for the total synthesis of this part of the gene for the tRNA precursor involved the DNA duplex consisting of segments 14 to 18, this duplex could not be quantitatively phosphorylated at the two 5'-OH ends for subsequent joining to the adjoining parts of the gene. The DNA duplex consisting of segments 13 to 19, which possesses both terminal 5'-OH groups at protruding single-stranded ends, was readily phosphorylated and used successfully in the total synthesis of the gene as described in an accompanying paper.
Reverse-link power control strategies for CDMA cellular network (2002)

Power control (PC) is an important issue in the DS-CDMA cellular mobile radio system. For the IS-95 standard, the reverse-link PC strategy is based on fixed-step power change and it needs only one command bit per update. We call this strategy DM-PC. From the point of view of digital communication, ADM will have better performance with the same number of control bits compared to DM. So it appears to be a good idea to improve the DM-PC and be compatible with the current system as IS-95. However, the pure ADM-PC is not better than DM-PC from our earlier simulation results. Hence, we propose another PC strategy called modified ADM-PC. The simulation results show that it has better performance than DM-PC.
Adenovirus-dependent release of choline from plasma membrane vesicles at an acidic pH is mediated by the penton base protein (1994)

It has been suggested that during receptor-mediated endocytosis of human adenovirus (Ad) type 2 into cells, Ad disrupts the membrane of endocytic vesicles to enter the cytosol. To understand the mechanism of Ad-mediated disruption of the endocytic vesicles, I exposed Ad to plasma membrane vesicles derived from KB cells. Ad caused release of choline from the plasma membrane vesicles preloaded with [3H]choline. The efflux of choline was dependent on (i) the concentration of Ad, with a half-maximal effect at 0.5 microgram/ml; (ii) the pH of the buffer, with the optimum pH of the reaction ranging from 5.5 to 6.0; (iii) the length of the incubation, with a half-maximal release at 2 min; and (iv) the temperature of the incubation, with the optimum temperature being 37 degrees C. The Ad-dependent release of choline was inhibited by anti-penton base, while antihexon did not block the effect. These results suggest roles for a low-pH environment and the penton base protein in the Ad-dependent efflux of choline from plasma membrane vesicles.
Rapid Analysis of the Quality of the Recording Coating on Ink Jet Printing in Preparation (2011)

Preparation of the recording coating on the ink jet printing (RC-IJP) is proposed. The microstructure of RC-IJP was analyzed by scanning electron microscopy and atomic force microscope. The surface infiltration process of RC-IJP was studied. Fourier transform near-infrared (FT-NIR) spectra showed the combination and overtone vibrations information of the hydrogen-containing groups in RC-IJP structure. NIR spectra combined with partial least-squares methods were proposed for the noncontact analysis of the surface infiltration time and weight per unit area in RC-IJP. Forty-five samples were selected for the calibration sets of the surface infiltration time and weight per unit area, respectively. Spectral pretreatment method was used to develop robust calibration models. After the spectral pretreatment was optimized, the determination coefficient (R(2)) of the surface infiltration time and weight per unit area were 0.90 and 0.97, respectively. The analytical results showed that NIR spectra had significant potential for the analysis of the surface infiltration time and weight per unit area of RC-IJP.
Salmonellae in Eggs (2019)

This chapter discusses Salmonella in eggs and explores a discussion of Salmonella enteritidis and the table egg, which have received so much publicity since 1988. It examines the Salmonella contamination of fertile hatching eggs and the impact of that on the contamination of raw poultry meat. Egg-associated outbreaks of salmonellosis, generally attributed to either bulk egg products or cracked shell eggs, occurred frequently before enactment of the 1970 Egg Products Inspection Act. A 1987 nosocomial outbreak at a New York hospital, traced to the use of raw eggs in the preparation of mayonnaise, was illustrative of the epidemiology of eggborne Salmonella enteritidis (SE) infections. Explaining the high rate of isolation of SE and the frequent association of some SE strains with eggs requires an understanding of the attributes that distinguish epidemiologically important strains from other SE strains and from other serotypes. Detectable antibodies to SE have been found in egg yolk by enzyme-linked immunosorbent assay and microantiglobulin methods.
Study of polycation effects on erythrocyte agglutination mediated by anti-glycophorins using microscopic image digital analysis (2006)

The aim of this work was to study synthetic polycation effects on erythrocyte agglutination mediated by anti-glycophorin using image digital analysis. Polycations are oligomers or polymers of natural or synthetic origin, which bear a great number of positive charges at pH 7.4. Several of these polycations are nowadays used in clinic for human and veterinary purposes. New applications of polycations to the development of new drug delivery systems are investigated, in order to promote the drug absorption through the gastro-intestinal and blood brain barriers. However, up to now, there are no clear relationships between macromolecular features of polycations (molecular weight, mean charge density, charge repartition, etc.) and their interactions with blood elements (which bear superficial negative charges). The interaction on the red blood cell membrane with synthetic polycations having well-controlled macromolecular features and functionalized with pendent polyethylene glycol segments was investigated. The alterations over stationary and dynamic viscoelastic properties of erythrocyte membranes were analyzed through laser diffractometry. Image digital analysis was used to study erythrocyte agglutination mediated by anti-glycophorin. Results show different reactivities of the polycations on the erythrocyte membrane. These findings could provide more information about the mechanisms of polycation interaction on erythrocyte membranes. We consider that this work could provide useful tools to understand and improve the haemocompatibility of polycations and enlarge their potential in clinic.
Data labelling in the wild: annotating free-living activities and Parkinson's disease symptoms (2021)

This paper looks to explore the challenges faced when producing a set of annotations from videos produced by a pilot study evaluating 24 participants (12 with Parkinson's disease, each accompanied by a healthy volunteer control participant) who are free-living in a house embedded with a platform of sensors. We discuss the outcome measures chosen to annotate from the videos and the controlled vocabularies formulated for this task, the tools and processes, how we intend to achieve standardisation and normalisation of the annotations, and how to improve quality and re-usability of the annotation dataset.
Provenance analysis: Towards quality provenance (2012)

Data provenance, a key piece of metadata that describes the lifecycle of a data product, is crucial in aiding scientists to better understand and facilitate reproducibility and reuse of scientific results. Provenance collection systems often capture provenance on the fly and the protocol between application and provenance tool may not be reliable. As a result, data provenance can become ambiguous or simply inaccurate. In this paper, we identify likely quality issues in data provenance. We also establish crucial quality dimensions that are especially critical for the evaluation of provenance quality. We analyze synthetic and real-world provenance based on these quality dimensions and summarize our contributions to provenance quality.
Fluridone and norflurazon, carotenoid‐biosynthesis inhibitors, promote seed conditioning and germination of the holoparasite Orobanche minor (2004)

Fluridone and norflurazon, two carotenoid-biosynthesis inhibitors, shortened the conditioning period required by seeds of Orobanche minor in order to respond to the germination stimulant strigol. Neither fluridone nor norflurazon alone induced seed germination of O. minor, they promoted strigol-induced germination. In addition, these compounds restored the conditioning and germination of seeds at a supraoptimal temperature (30 degrees C) as well as in the light. Gibberellic acid (GA(3)) showed similar promotive and protective effects on the conditioning and germination of O. minor seeds. Although fluridone and norflurazon are known to prevent abscisic acid (ABA)-biosynthesis, and stresses such as supraoptimal temperatures have been reported to induce ABA accumulation in plants, the amount of ABA in the seeds or that released from the seeds into the conditioning media was not affected by the fluridone treatment and by exposure to the supraoptimal temperature. These results indicate that the promotive and protective effects of fluridone and norflurazon on the conditioning and germination of O. minor seeds would be attributed to other perturbations rather than the inhibition of ABA-biosynthesis.
Is Modified K-line a Powerful Tool of Surgical Decision Making for Patients With Cervical Spondylotic Myelopathy? (2019)

Preoperative intervention using the mK-line is useful to predict residual cord compression and might homogenize postoperative clinical outcomes in both anterior surgery and PS.
NIMG-16. IMAGING PREFERENCES IN LOW-GRADE GLIOMAS - RESULTS OF A MULTINATIONAL SURVEY (2017)

Despite recent advances in surgery, chemo- and radiation therapy, diffuse low-grade glioma are still incurable. According to current guidelines, maximum safe resection, is the first line of treatment. Apart from surgery, all other treatment modalities are handled very differently among different teams. Additionally, imaging of low-grade gliomas is a field of great variety throughout different centers. We aimed to obtain data on imaging in LGG, in order to identify a “minimal core of imaging” that is performed in every participating center. We carried out a survey among centers in Europe, sent through channels of the European Association of Neurosurgical Societies (EANS), the German and Austrian National Society (DGNC and OEGNC) and the ELGGN representing a multidisciplinary society. The online survey consisted of 38 items in total and took place in March and April 2017, during that time, 140 complete surveys were received. Descriptive analysis of results was performed. Of all centers submitting the survey, 73% were academic. Nearly half (46%) of the centers maintain a dedicated LGG-program in their practice. The annual amount of LGG-cases treated differed between 10 and 200. The heterogeneity of imaging protocols showed that 50% of centers are willing to use any recently performed MRI, whereas only 31% scan their own MRI protocol in patients with LGG. The results showed that only 36% of centers involved performed PET scans in patients with suspected LGG and 80% of centers relied on MRI to assess treatment response and progression. Further data obtained on treatment response showed that 41% of centers performed a linear measurements, whereas only 33% perform volumetric analysis. We could depict a minimal core of imaging, consisting of several MRI sequences, that will serve as foundation for future trials of treatment response and surgical accuracy.
Surface Plasmon Fluorescence Immunoassay of Free Prostate-Specific Antigen in Human Plasma at the Femtomolar Level (2004)

This study describes the development of a surface plasmon fluorescence spectroscopy (SPFS)-based sandwich immunoassay, for the detection of free prostate-specific antigen (f-PSA). The commercial CM5 chip (Biacore) was integrated into the SPFS-based assay making use of its three-dimensionally extended dextran architecture, which offers a large protein retention capacity and alleviates the metal-induced fluorescence quenching. The performance of the f-PSA assay was investigated in buffer and in human plasma, respectively. In the human plasma, the limit of detection of f-PSA was estimated to be approximately 80 fM for 40 min of contact time, which adequately meets clinical requirements.
Media testing technology for magnetic defects detection and measurement (2009)

As areal density increases towards TB/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> domain, improved detection capability of media defects become more critical. We have developed a media tester with concurrent multi-functional testing. Testing results using specially fabricated sample for missing pulse and optical surface analyzer measurement were compared. The former was found superior in detection sensitivity and resolution, and shown to be useful also for indirect detection of media surface physical variations. However the missing pulse approach needs to be correlated with other concurrent tests such as Laser Doppler Vibrometry and Acoustic Emission, so that spurious results can be eliminated. Such concurrent testing on a single tester is important towards providing an ldquoaccurate picturerdquo of the tested media surface and condition.
Telomere Length and Telomerase Activity in Carcinogenesis of the Stomach (1997)

Telomerase activity is generally absent in primary cell cultures and normal tissues. Telomerase is known to be induced upon immortalization or malignant transformation of human cells. In the present study, we analyzed both telomere length and telomerase activity in biopsy samples from mucosa undergoing metaplasia, adenoma and cancer of the stomach. We attempted to estimate the correlation between telomerase activity and telomere length in these tissues. Telomerase activity was estimated using the telomeric repeat amplification protocol and telomere length by Southern blot analysis. Extracts were defined as telomerase-negative when the signals were less intense than those for 10(2) KATO-III cells (positive control). We detected telomerase activity in 15%, 45% and 89% of the examined cases of intestinal metaplasia, adenoma and gastric cancer respectively. However, telomere length in the gastric mucosa became reduced as the mucosa underwent metaplasia and developed into adenoma. Gastric cancers showed a broad range of telomere length among cases. However, gastric adenomas showed the shortest telomere length. These results suggest that telomerase is expressed during the early phase (intestinal metaplasia through adenoma) of gastric carcinogenesis, although the activity at that stage is not high enough to fully restore the reduced telomeric DNA.
ChemInform Abstract: A Chemoenzymatic Elaboration of a Quaternary Chiral Center: An Alternative Approach to the Side Chain of Furaquinocin D. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Employing electro-mechanical analogies for co-resonantly coupled cantilever sensors (2016)

Abstract. Understanding the behaviour of mechanical systems can be facilitated and improved by employing electro-mechanical analogies. These analogies enable the use of network analysis tools as well as purely analytical treatment of the mechanical system translated into an electric circuit. Recently, we developed a novel kind of sensor set-up based on two coupled cantilever beams with matched resonance frequencies (co-resonant coupling) and possible applications in magnetic force microscopy and cantilever magnetometry. In order to analyse the sensor's behaviour in detail, we describe it as an electric circuit model. Starting from a simplified coupled harmonic oscillator model with neglected damping, we gradually increase the complexity of the system by adding damping and interaction elements. For each stage, various features of the coupled system are discussed and compared to measured data obtained with a co-resonant sensor. Furthermore, we show that the circuit model can be used to derive sensor parameters which are essential for the evaluation of measured data. Finally, the much more complex circuit representation of a bending beam is discussed, revealing that the simplified circuit model of a coupled harmonic oscillator is a very good representation of the sensor system.