gebhart/patrepeval huggingface dataset:
Laser testing of an Iris AO dielectric-coated segmented MEMS DM (2011)

Iris AO has been developing dielectric-coated segmented MEMS deformable mirrors (DM) for use in laser applications that range from 355-1540 nm. In order to mitigate deformation from residual stress in the thick dielectric coatings, a stress-compensation layer has been added to the underside if the DM segments. This paper describes fabrication results of DMs with high reflectance dielectric coatings for 532 nm, 1064 nm, and 1540 nm. Additionally, a DM with a 532 nm coating has been tested with a 2 W, 532 nm CW laser. Laser testing shows the DM can handle 300 W/cm<sup>2</sup> with off-theshelf packaging. Projections show that with good heat sinking, the same DM can handle laser power densities of 2800 W/cm<sup>2</sup>. The coatings showed no signs of damage after exposure to a w<sub>0</sub>=25 &mu;m beam with a power density of 205 kW/cm<sup>2</sup> for 105 minutes at the center of a segment and at segment edges exposed to 180 kW/cm<sup>2</sup> for 45 minutes.
Neolignans and Other Metabolites from Ocotea cymosa from the Madagascar Rain Forest and Their Biological Activities (2015)

Ten new neolignans including the 6'-oxo-8.1'-lignans cymosalignans A (1a), B (2), and C (3), an 8.O.6'-neolignan (4a), ococymosin (5a), didymochlaenone C (6a), and the bicyclo[3.2.1]octanoids 7-10 were isolated along with the known compounds 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan, 3,4,5,3'-tetramethoxy-1'-allyl-8.O.4'-neolignan, didymochlaenone B, virologin B, ocobullenone, and the unusual 2'-oxo-8.1'-lignan sibyllenone from the stems or bark of the Madagascan plant Ocotea cymosa. The new 8.O.6'-neolignan 4a, dihydrobenzofuranoid 5a, and the bicyclo[3.2.1]octanoid 7a had in vitro activity against Aedes aegypti, while the new compounds 5a, 7a, 8, and 10a and the known virolongin B (4b) and ocobullenone (10b) had antiplasmodial activity. We report herein the structure elucidation of the new compounds on the basis of spectroscopic evidence, including 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometry, and the biological activities of the new and known compounds.
Role of a Membrane‐activated Structural Switch Mechanism in Chloroplast SRP Receptor Function (2009)

Prokaryotic and eukaryotic signal recognition particles (SRPs) differ in the ability of the SRP receptor to partition between an aqueous phase and target membranes during protein targeting. Though membrane binding has been shown to be functionally critical for E. coli SRP receptor function, the regulation of the SRP particle receptor partitioning and the conformation of its membrane‐bound state remain unclear. Our study objective was to identify the critical region responsible for membrane binding in the chloroplast SRP (cpSRP) receptor, cpFtsY. Using recombinant cpFtsY, we have identified a small N‐terminal region responsible for stabilizing a membrane interaction critical to the cpFtsY function in cpSRP‐dependent protein targeting. Functional studies of this region reveal that it is both necessary and sufficient for binding the target membrane. Furthermore, NMR and CD structural studies of this region and a similar region in the E. coli SRP receptor reveal a conformational change in secondary structure that takes place upon lipid binding and correlates with a stimulation of GTP hydrolysis by cpFtsY in the presence of liposomes. These studies suggest a conserved mechanism for both membrane binding and the intramolecular communication that regulates cpSRP receptor functions at the membrane. This research is supported by NIH Grant P20 RR15569 from the COBRE Program of the NCRR and DOE Grant DE‐FG02‐01ER15161.
Blueberries. By J. B. Retamales and J. F. Hancock. Wallingford, UK: CABI (2012), pp. 336, £45.00. ISBN 978-1-84593-826-0. (2012)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
A Teaching Assistant for the C Language (Short Paper) (2021)

We introduce a C tutor that can help instructors manage classes with many students learning to program in C. Nowadays, it is easy to evaluate code but it is hard to provide good feedback. We introduce a tool to help instructors provide students with feedback concerning their implementation and documentation for honing their programming skills. This tool is implemented in Python and is available at https://github.com/rcm/C_teaching_assistant.
The Sleep of Abstinent Pure Primary Alcoholic Patients: Natural Course and Relationship to Relapse (1998)

Sleep in male pure primary alcoholic inpatients was examined at a mean of 16 days (n = 29), 19 weeks (n = 29), 14 months (n = 9), and 27 months (n = 4) of abstinence. Results were as follows: (1) the sleep of abstinent alcoholic patients is short, fragmented, and shallow early in abstinence; (2) a patient's sleep improves slowly over at least the first year of abstinence; however, (3) some facets of a patient's sleep remain abnormal even after 27 months of abstinence; (4) insomnia and sleep fragmentation after approximately 5 months of abstinence may be related to relapse by 14 months. The mechanism underlying the relationship between sleep and withdrawal in alcoholic patients is not well understood, and the issue of treating sleep problems as an adjunct to prevention of relapse warrants further investigation.
A condensed modal functional for identifying equivalent constitutive properties of an assembled induction motor (2009)

International audience
Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease (2013)

In Alzheimer disease (AD), the microtubule-associated protein tau is highly phosphorylated and aggregates into characteristic neurofibrillary tangles. Prostate-derived sterile 20-like kinases (PSKs/TAOKs) 1 and 2, members of the sterile 20 family of kinases, have been shown to regulate microtubule stability and organization. Here we show that tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. Notably, phosphorylated residues include motifs located within the microtubule-binding repeat domain on tau (Ser-262, Ser-324, and Ser-356), sites that are known to regulate tau-microtubule interactions. PSK catalytic activity is enhanced in the entorhinal cortex and hippocampus, areas of the brain that are most susceptible to Alzheimer pathology, in comparison with the cerebellum, which is relatively spared. Activated PSK is associated with neurofibrillary tangles, dystrophic neurites surrounding neuritic plaques, neuropil threads, and granulovacuolar degeneration bodies in AD brain. By contrast, activated PSKs and phosphorylated tau are rarely detectible in immunostained control human brain. Our results demonstrate that tau is a substrate for PSK and suggest that this family of kinases could contribute to the development of AD pathology and dementia.
Polymeric microfluidic devices for the monitoring and separation of water-borne pathogens utilizing insulative dielectrophoresis (2005)

We have successfully demonstrated selective trapping, concentration, and release of various biological organisms and inert beads by insulator-based dielectrophoresis within a polymeric microfluidic device. The microfluidic channels and internal features, in this case arrays of insulating posts, were initially created through standard wet-etch techniques in glass. This glass chip was then transformed into a nickel stamp through the process of electroplating. The resultant nickel stamp was then used as the replication tool to produce the polymeric devices through injection molding. The polymeric devices were made of Zeonor 1060R, a polyolefin copolymer resin selected for its superior chemical resistance and optical properties. These devices were then optically aligned with another polymeric substrate that had been machined to form fluidic vias. These two polymeric substrates were then bonded together through thermal diffusion bonding. The sealed devices were utilized to selectively separate and concentrate a variety of biological pathogen simulants and organisms. These organisms include bacteria and spores that were selectively concentrated and released by simply applying D.C. voltages across the plastic replicates via platinum electrodes in inlet and outlet reservoirs. The dielectrophoretic response of the organisms is observed to be a function of the applied electric field and post size, geometry and spacing. Cells were selectively trapped against a background of labeled polystyrene beads and spores to demonstrate that samples of interest can be separated from a diverse background. We have implemented a methodology to determine the concentration factors obtained in these devices.
ChemInform Abstract: 3‐Heteroatom‐Substituted Alkanoic Acid Esters (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design of the Java HotSpot™ client compiler for Java 6 (2008)

Version 6 of Sun Microsystems' Java HotSpot™ VM ships with a redesigned version of the client just-in-time compiler that includes several research results of the last years. The client compiler is at the heart of the VM configuration used by default for interactive desktop applications. For such applications, low startup and pause times are more important than peak performance. This paper outlines the new architecture of the client compiler and shows how it interacts with the VM. It presents the intermediate representation that now uses static single-assignment (SSA) form and the linear scan algorithm for global register allocation. Efficient support for exception handling and deoptimization fulfills the demands that are imposed by the dynamic features of the Java programming language. The evaluation shows that the new client compiler generates better code in less time. The popular SPECjvm98 benchmark suite is executed 45% faster, while the compilation speed is also up to 40% better. This indicates that a carefully selected set of global optimizations can also be integrated in just-in-time compilers that focus on compilation speed and not on peak performance. In addition, the paper presents the impact of several optimizations on execution and compilation speed. As the source code is freely available, the Java HotSpot™ VM and the client compiler are the ideal basis for experiments with new feedback-directed optimizations in a production-level Java just-in-time compiler. The paper outlines research projects that add fast algorithms for escape analysis, automatic object inlining, and array bounds check elimination.
Characterization of acute stress reaction following an IED blast-related mild traumatic brain injury (2015)

A history of multiple mTBIs is associated with increased risk of ASR. Future research is warranted.
Immunoassay for intact amino-terminal propeptide of human type I procollagen (1996)

We have developed quantitative immunoassays for the intact, trimeric amino-terminal propeptide of human type I procollagen (PINP) and its Col1 domain. Intact PINP was isolated from the pleural fluids of cancer patients by a combination of ion-exchange, gel-filtration, and reversed-phase chromatographies. The amino-terminal Col1 domain of PINP was isolated after bacterial collagenase treatment of the heat-denatured trimeric propeptide. For the intact PINP assay we used a polyclonal antibody with only 1.2% cross-reaction with the monomeric Col1 domain. In human serum, this assay detects only one peak of PINP antigenicity that has the size of known intact PINP. Under similar conditions, an assay for the Coll domain of PINP recognized two circulating antigens. The biological relevance was further verified in wound fluid. Interassay and intraassay CVs were 3.1-9.3% for values within the reference intervals (mean +/- 2SD) for intact PINP in serum, which were 19-84 microg/L for women and 20-76 microg/L for men.
Microwave Active Filter using Finite Gain Amplifier (2002)

This paper deals with the design of microwave analog biquadratic filters using voltage amplifiers. A prototype bandpass filter is monolithically integrated. The chip size is only 1.3 mm2 on GaAs substrate. The filter specifications are: 2Ghz central frequency and a 3dB bandwidth of 40 MHz. A comparison with the SiGe bipolar technology is represented. The circuit represents a building block suitable for use in the cascade realization of higher order filters.
Noise-induced leakage and counting errors in the electron pump (2000)

Computer simulations reveal that the lowest rates of leakage and counting errors observed in the electron pump can be explained by photon-assisted tunneling driven by $1/f$ noise. The noise power at microwave frequencies required to account for the observed errors is consistent with extrapolation of the low-frequency noise spectrum commonly recorded in single-electron transistors. Pump simulations, based on the ground-capacitance model, include cotunneling as well as single-junction photon-assisted tunneling. Quantitative agreement between theory and experiment is obtained for leakage and counting errors in pumps with four, five, six, and seven junctions in the limit of low temperatures and low counting rates. The effect of self-heating is explored.
Non-Orthogonal Random Access for 5G Networks (2017)

The massive amounts of machine-type user equipments (UEs) will be supported in the future fifth generation (5G) networks. However, the potential large random access (RA) delay calls for a new RA scheme and for a detailed assessment of its performance. Motivated by the key idea of non-orthogonal multiple access, the non-orthogonal RA (NORA) scheme based on successive interference cancellation (SIC) is proposed in this paper to alleviate the access congestion problem. Specifically, NORA utilizes the difference of time of arrival to identify multiple UEs with the identical preamble, and enables power domain multiplexing of collided UEs in the following access process, while the base station performs SIC based on the channel conditions obtained through preamble detection. Our analysis shows that the performance of the NORA is superior to the conventional orthogonal RA (ORA) scheme in terms of the preamble collision probability, access success probability, and the throughput of RA. Simulation results verify our analysis and further show that our NORA scheme can improve the number of the supported UEs by more than 30%. Moreover, the number of preamble transmissions and the access delay for successfully accessed UEs are also reduced significantly by using the proposed RA scheme.
Development of the Optimum Operation Scheduling Model of Domestic Electric Appliances for the Supply-Demand Adjustment in a Power System (2010)

The high penetration of variable renewable generation such as Photovoltaic (PV) systems will cause the issue of supply-demand imbalance in a whole power system. The activation of the residential power usage, storage and generation by sophisticated scheduling and control using the Home Energy Management System (HEMS) will be needed to balance power supply and demand in the near future. In order to evaluate the applicability of the HEMS as a distributed controller for local and system-wide supply-demand balances, we developed an optimum operation scheduling model of domestic electric appliances using the mixed integer linear programming. Applying this model to several houses with dynamic electricity prices reflecting the power balance of the total power system, it was found that the adequate changes in electricity prices bring about the shift of residential power usages to control the amount of the reverse power flow due to excess PV generation.
Structure and extinction of counterflow diffusion flames above condensed fuels: Comparison between poly(methyl methacrylate) and its liquid monomer, both burning in nitrogen–air mixtures (1978)

Abstract Since poly(methyl methacrylate) is known to depolymerize largely to its monomer when heated, the chemical kinetics in the gaseous diffusion flame produced by this polymer in a fire may coincide with that of burning liquid methyl methacrylate. To test this hypothesis, flat diffusion flames were probed and extinguished adjacent to surfaces of each of these fuels. Profiles of temperature and of concentrations of stable chemical species are reported, as are gas velocities of approach flow required to produce extinction for various oxygen/nitrogen ratios of the stream. Results revealed structural differences attributable to differing thermal properties of the fuels. Many fuel species were observed in the gas phase, their profiles being partially rationalized on the basis of a suggested decomposition mechanism for gaseous methyl methacrylate. Overall kinetic parameters for gasphase combustion, obtained by use of extinction results in a previously developed theory, are nearly the same for the polymer and monomer but appear to differ by amounts exceeding experimental uncertainties. It is suggested that this may be traced to small differences in fuel species leaving the condensed phase which, for the polymer, is covered by a thin, two‐phase region.
Dependence of M1 RNA substrate specificity on magnesium ion concentration (1988)

We have constructed a plasmid expressing E. coli M1 RNA, the catalytic RNA subunit of ribonuclease P, under the control of a phage T7 promoter. The active M1 RNA species synthesized in vitro by T7 RNA polymerase from this vector was reacted with the tRNA(Gln) - tRNA(Leu) precursor RNA (Band K) encoded by phage T4. Only the tRNA(Leu) moiety of this dimeric precursor RNA contains the 3' terminal C-C-A sequence common to all tRNAs. We observed that protein-free M1 RNA was capable of processing the precursor RNA at the 5' ends of both tRNA tRNA sequences. The rate of cleavage of the tRNA(Gln) sequence was more strongly dependent on [Mg2+] than that of tRNA(Leu), increasing severalfold between 100 and 500 mM Mg2+, conditions under which the rate of cleavage at the tRNA(Leu) sequence was constant.
Boron functionalization of hydridotris(pyrazolyl)borate ligand on osmium complexes (2014)

Trabajo presentado a la XXXII Conference Expert Group Meeting on Organometallic Chemistry celebrada en Tarragona (España) del 17 al 19 de septiembre de 2014.
The pharmacokinetics of antibiotic diffusion in chronic bacterial prostatitis (1982)

Historically chronic bacterial prostatitis in the male human has been relatively resistant to antimicrobial chemotherapy. The pharmacokinetic theory of drug diffusion into the prostate is reviewed. A brief description of the various canine models utilized to quantitate antimicrobial drug diffusion is presented. Specific data concerning the diffusion of various antimicrobial agents are abstracted followed by a brief discussion of mechanistic explanations for the success or failure of drug therapy.
Transcatheter edge-to-edge mitral valve repair in heart failure (2017)

Heart failure and severe mitral regurgitation (MR) are mutually dependent. Secondary MR is a consequence of chronic heart failure in patients with severely depressed left ventricular ejection fraction (LV-EF) and LV dilatation. Severe MR in heart failure patients worsens prognosis and accelerates LV dilatation and decline in LV-EF. Interventional therapies have changed clinical practice for heart failure patients with secondary MR. In this review we summarize the available data of patients with chronic heart failure undergoing transcatheter edge-to-edge mitral valve repair (TMVR) with the MitraClip® system for severe secondary mitral regurgitation. TMVR could be a therapeutic option with a favorable long-term outcome even in patients with severely depressed LV-EF. Selection criteria predicting mortality in patients undergoing TMVR comprise clinical, laboratory and echocardiographic parameters and can help for clinical decision-making. Ongoing randomized trials will influence the use of interventional treatment of MR in these high-risk patients.
Modélisation et Analyse de Défauts Non-Francs dans les Lignes de Transmission en vue du Diagnostic (2015)

International audience
Thin films of binary amorphous Zn-Zr alloys developed by magnetron co-sputtering for the production of degradable coronary stents: A preliminary study (2018)

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Carbonate Sedimentation and Diagenesis in the Evolving Precambrian World (2000)

Carbonate Sedimentation and Diagenesis in the Evolving Precambrian World - Precambrian carbonates are usually regarded at the simple cousins of the sedimentary realm, composed of stromatolites and dolostones, texturally not challenging and commonly altered beyond recognition by the vagaries of time, diagenesis and metamorphism. However, these carbonates that formed deep in time are commonly exquisitely preserved and contain within them a record of the evolving young earth. SEPM Special Publication 67 explores these aspects. Resulting from a 1997 SEPM/CSPG symposium entitled? Precambrian Carbonates,? these 18 papers demonstrate the importance of understanding these rocks, since within them is contained a record of the early ocean, atmosphere, and biosphere.
Penetration of hypochlorites with lowered surface tension into dentine tubules. (2016)

The exposure time and temperature of sodium hypochlorite as well as the addition of surfactants may influence the penetration depth of irrigants into dentinal tubules.
Papillomaviruses in Human Pathology: Recent Progress in Epidermoid Precancers. (1991)

Journal Article Papillomaviruses in Human Pathology: Recent Progress in Epidermoid Precancers. Get access Monsonegro J., (ed). Papillomaviruses in Human Pathology: Recent Progress in Epidermoid Precancers.. New York: Raven Press, 1991. Price $87.00. Christopher P. Crum, MD Christopher P. Crum, MD Brigham and Women's Hospital and Harvard Medical School Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 96, Issue 3, 1 September 1991, Page 401, https://doi.org/10.1093/ajcp/96.3.401 Published: 01 September 1991
Tetraspine: Robust terrain handling on a tensegrity robot using central pattern generators (2013)

In order to produce a new mode of robust robotic locomotion and better understand how vertebrates coordinate motion with a compliant spine, we are developing a modular tensegrity robot inspired by the spine. The robot, called Tetraspine, is composed of rigid tetrahedron-shaped segments connected by six strings. Distributed impedance controllers coupled with central pattern generators (CPGs) generate tunable motion in the structure, making this the first mobile terrestrial tensegrity robot controlled by CPGs to the authors' knowledge. By eliminating rigid joints between segments and increasing compliance in the structure, Tetraspine is robust to perturbations; it traverses several types of irregular terrain successfully in simulation. Experiments in prototype hardware have proven the viability of the impedance controller and overall structure for locomotion.