gebhart/patrepeval huggingface dataset:
Bicycling-induced ulnar tunnel syndrome. (2003)

Symptoms of ulnar tunnel syndrome are commonly experienced by avid bicyclists. Previous orthopedic and hand surgery publications have rarely included bicycling as a causative factor for this condition. We present the case of a 41-year-old man who developed bilateral ulnar tunnel syndrome during a week-long mountain bicycling tour. His symptoms gradually improved with nonoperative treatment measures, including rest, splinting, and nonsteroidal anti-inflammatory medication.
Lamivudine treatment in a patient with hepatitis B virus reactivation after allogenic peripheral bone marrow transplantation (2005)

We report the case of a 52-year-old woman with hepatitis B virus (HBV) reactivation during treatment for chronic graft vs. host disease (GVHD) after peripheral bone marrow transplantation (PBSCT) to treat chronic myelocytic leukemia. She was given cyclosporine and prednisolone orally to treat chronic GVHD after PBSCT. Liver dysfunction first developed 25 months after transplantation with the appearance of hepatitis B s antigen (HBsAg), hepatitis B e antigen (HBeAg), and elevation of HBV-DNA up to 4.5 log copies/ml. Retrospective examination of her serum before PBSCT proved negative for HBsAg and HBeAg, and positive for anti-HBsAg, anti-HBeAg, anti-hepatitis B core antigen, and HBV-DNA (2.7 log copies/ml), showing that she was in a state of occult HBV infection. Nucleotide sequences of the HBV genome obtained from her serum showed no core promoter mutations at nt 1762 and 1764 and no pre-core mutation at nt 1896. Polymerase chain reaction-restriction fragment length polymorphism showed that she was infected with HBV genotype B. The administration of lamivudine, a nucleoside analog, improved her liver function and reduced HBV-DNA replication. We conclude that antiviral agents, such as lamivudine, are effective for treating hepatitis B reactivation during immunosuppressive treatment, such as for GVHD. The administration of a nucleoside analog before transplantation should also be considered in the light of HBV genotypes and mutations, even if HBsAg was negative and the viral load was low before transplantation.
Digital control of active magnetic bearings (1990)

Theoretical relationships are developed to relate the characteristics of a controller transfer function to the stiffness and damping properties of an active magnetic bearing for machine rotors. Both proportional and derivative feedback are shown to be necessary for closed-loop system stability, and, for the ideal case, bearing stiffness and damping properties are shown to be simple linear functions of the proportional and derivative feedback gain constants, respectively. The flexibility of a digitally controlled magnetic bearing is demonstrated by the implementation of algorithms which include second-derivative and integral feedback. Second-derivative feedback is shown to be effective at extending the usable bandwidth of the digital controller, and integral feedback rejects rotor position error in the presence of static loads. The relationship between controller sampling rate and bearing performance is investigated, and it is shown that increased sampling rate and increased amounts of second-derivative feedback have similar effects on the bearing properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 19328: Delayed Ticagrelor Pharmacodynamic Effect in ACS in the Absence of Morphine Therapy and Hemodynamic Compromise (2016)

Introduction: The largest body of pharmacodynamic (PD) data on the antiplatelet effect of ticagrelor has been derived from the blood of patients with stable coronary artery disease and the PD effec...
Synthesis of a Phthaloylglycine-Derived Strigol Analogue and Its Germination Stimulatory Activity toward Seeds of the Parasitic Weeds Striga hermonthica and Orobanche crenata (1997)

The newly designed strigol analogue Nijmegen 1 (rac 7) was prepared in high overall yield starting from N-phthaloylglycine. This relatively simple analogue exhibits high bioactivity in the stimulation of germination of seeds of the parasitic weeds Striga hermonthica and Orobanche crenata. Nijmegen 1 was resolved in its enantiomers 7 and ent 7 by using the homochiral latent D-rings ent 11 and ent 12. The enantiomers 7 and ent 7 show significant differences in germination activity. Keywords: Striga; Orobanche; germination; strigol analogue
Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA (2020)

IARC; MH CZ - DRO; MH SK; exchange program between IARC and Sao Paulo medical Sciences; French Cancer League.
A novel feedback reduction technique for cellular downlink with CDF-based scheduling (2013)

Cumulative distribution function (CDF)-based scheduling is known as an efficient scheduling method that can assign different time fractions for user access or, equivalently, satisfy different channel access ratio requirements of users in cellular downlink while exploiting multi-user diversity. In this paper, we propose CDF-FR, a feedback reduction technique for CDF-based scheduling that reduces feedback overhead from users in a cell. Although several threshold based feedback reduction schemes have been proposed for various scheduling algorithms, none of them considers users' different channel access ratio requirements for which CDF-based scheduling is designed. In the proposed technique, a single threshold is used for all users who have different channel access ratio requirements. We show that this simple setting is sufficient for CDF-FR to satisfy users' diverse channel access ratio requirements. It is proved that the average feedback overhead of CDF-FR is upper-bounded by - lnp for an arbitrary number of users in a cell, where p represents the probability that no user satisfies the threshold condition. Furthermore, the normalized throughput loss due to feedback reduction is upper-bounded by p in fading channels with arbitrary statistics.
CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy (2010)

We have studied the photodynamic properties of novel CdTe quantum dots-methylene blue hybrid photosensitizer. Absorption spectroscopy, photoluminescence spectroscopy, and fluorescence lifetime imaging of this system reveal efficient charge transfer between nanocrystals and the methylene blue dye. Near-infrared photoluminescence measurements provide evidence for an increased efficiency of singlet oxygen production by the methylene blue dye. In vitro studies on the growth of HepG2 and HeLa cancerous cells were also performed, they point toward an improvement in the cell kill efficiency for the methylene blue-semiconductor nanocrystals hybrid system.
<title>128X1 GaAs/AlGaAs multiple quantum well infrared detector array</title> (1998)

A long-wavelength 128 by 1 GaAs/AlGaAs multiple quantum wells (MQWs) infrared detector (IRD) array is presented. A good photo-current responsibility R<SUB>p</SUB> equals 2.02 X 10<SUP>6</SUP>V/W is obtained with the cut-off wavelength being (lambda) <SUB>c</SUB> equals 8.6 micrometer and as a result, we obtain a good remanent heat image of a room-temperature subject.
Deep hypertext with embedded revision control implemented in regular expressions (2010)

While text versioning was definitely a part of the original hypertext concept [21, 36, 44], it is rarely considered in this context today. Still, we know that revision control underlies the most exciting social co-authoring projects of the today's Internet, namely the Wikipedia and the Linux kernel. With an intention to adapt the advanced revision control technologies and practices to the conditions of the Web, the paper reconsiders some obsolete assumptions and develops a new versioned text format perfectly processable with standard regular expressions (PCRE [6]). The resulting deep hypertext model allows instant access to past/concurrent versions, authorship, changes; enables deep links to reference changing parts of a changing text. Effectively, it allows distributed and real-time revision control on the Web, implementing the vision of co-evolution and mutation exchange among multiple competing versions of the same text.
Regulation of eukaryotic protein synthesis: Selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1 (1999)

To better understand regulation of eukaryotic protein synthesis, we studied cellular and viral mRNA translation in influenza virus-infected cells. Influenza virus infection results in a dramatic shut-off of cellular protein synthesis that is concomitant with selective viral mRNA translation. Earlier work showed that these events are mediated by viral and/or cellular factors binding to the 5' untranslated region (5' UTR) of viral mRNAs. To identify trans-acting cellular proteins responsible for selective viral protein synthesis, we employed the yeast three-hybrid system. Using the 5' UTR of the influenza virus nucleocapsid protein (NP) mRNA as bait, we identified the cellular RNA-recognition motif containing RNA-binding protein G-rich sequence factor 1 (GRSF-1) as a positive-acting translational regulatory factor. The in vivo yeast assay revealed GRSF-1 specifically bound to the NP 5' UTR but not select NP 5' UTR mutants or cellular RNA 5' UTRs. These data were confirmed by gel shift assays using recombinant GRSF-1. Importantly, recombinant GRSF-1 specifically stimulated translation of a NP 5' UTR-driven template in cell-free translation systems. Furthermore, translation efficiency of NP 5' UTR-driven templates was reduced markedly in GRSF-1-depleted HeLa cell extracts, but restored in GRSF-1-reconstituted extracts. GRSF-1 also stimulated translation of an NP 5' UTR-driven template in HeLa cell extracts that were depleted of essential factors by addition of RNA oligonucleotides representing the viral 5' UTR RNA. Taken together, these data document the functional demonstration of a cellular protein binding to influenza virus RNAs and, importantly, suggest that influenza virus may recruit GRSF-1 to the 5' UTR to ensure preferential translation of viral mRNAs in infected cells.
Are myotonia and epilepsy linked by a chloride channel? (2013)

Chen et al.1 report 2 novel findings: a truncation mutation in the CLCN1 gene, encoding the chloride channel protein ClC-1, in a patient with myotonic dystrophy and generalized epilepsy; and an excess of variation in CLCN1 in patients with epilepsy compared to controls. They also demonstrate expression of C1C-1 mRNA and protein in human brain autopsy specimens and mouse brain. Mutations in the CLCN1 gene have been long recognized as the cause of dominant (Thomsen-type) and recessive (Becker-type) myotonia but an association with epilepsy has not been reported. Until now it was believed that ClC-1 protein and channels were not expressed in the brain; therefore, the mutation would have no effect on the CNS. The patient reported in this study had generalized epilepsy and generalized seizures, which involve thalamocortical circuits. Interestingly, the authors found that ClC-1 mRNA was moderately expressed in the mouse thalamus and cortex. The clinical phenotype, combined with the animal data, strongly suggests a role for ClC-1 in the brain.
Unsupervised Cross-Modal Synthesis of Subject-Specific Scans (2015)

Recently, cross-modal synthesis of subject-specific scans has been receiving significant attention from the medical imaging community. Though various synthesis approaches have been introduced in the recent past, most of them are either tailored to a specific application or proposed for the supervised setting, i.e., they assume the availability of training data from the same set of subjects in both source and target modalities. But, collecting multiple scans from each subject is undesirable. Hence, to address this issue, we propose a general unsupervised cross-modal medical image synthesis approach that works without paired training data. Given a source modality image of a subject, we first generate multiple target modality candidate values for each voxel independently using cross-modal nearest neighbor search. Then, we select the best candidate values jointly for all the voxels by simultaneously maximizing a global mutual information cost function and a local spatial consistency cost function. Finally, we use coupled sparse representation for further refinement of synthesized images. Our experiments on generating T1-MRI brain scans from T2-MRI and vice versa demonstrate that the synthesis capability of the proposed unsupervised approach is comparable to various state-of-the-art supervised approaches in the literature.
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma (2015)

Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop drug combinations that target these resistance mechanisms. In a combinatorial drug screen on a panel of 12 treatment-naïve BRAFV600E mutant melanoma cell lines of varying levels of resistance to mitogen-activated protein kinase (MAPK) pathway inhibition, we identified the combination of PLX4720, a targeted inhibitor of mutated BRaf, and lapatinib, an inhibitor of the ErbB family of receptor tyrosine kinases, as synergistically cytotoxic in the subset of cell lines that displayed the most resistance to PLX4720. To identify potential mechanisms of resistance to PLX4720 treatment and synergy with lapatinib treatment, we performed a multi-platform functional genomics analysis to profile the genome as well as the transcriptional and proteomic responses of these cell lines to treatment with PLX4720. We found modest levels of resistance correlated with the zygosity of the BRAF V600E allele and receptor tyrosine kinase (RTK) mutational status. Layered over base-line resistance was substantial upregulation of many ErbB pathway genes in response to BRaf inhibition, thus generating the vulnerability to combination with lapatinib. The transcriptional responses of ErbB pathway genes are associated with a number of transcription factors, including ETS2 and its associated cofactors that represent a convergent regulatory mechanism conferring synergistic drug susceptibility in the context of diverse mutational landscapes.
Coupling between Ion Drift and Kinetics of Electronic Current Transients in MAPbBr3 Single Crystals (2022)

The optoelectronic properties of halide perovskite materials have fostered their utilization in many applications. Unravelling their working mechanisms remains challenging because of their mixed ionic-electronic conductive nature. By registering, with high reproducibility, the long-time current transients of a set of single-crystal methylammonium lead tribromide samples, the ion migration process was proved. Sample biasing experiments (ionic drift), with characteristic times exhibiting voltage dependence as ∝ <i>V</i> <sup>-3/2</sup>, is interpreted with an ionic migration model obeying a ballistic-like voltage-dependent mobility (BVM) regime of space-charge-limited current. Ionic kinetics effectively modify the long-time electronic current, while the steady-state electronic currents' behavior is nearly ohmic. Using the ionic dynamic doping model (IDD) for the recovering current at zero bias (ion diffusion), the ionic mobility is estimated to be ∼10<sup>-6</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>. Our findings suggest that ionic currents are negligible in comparison to the electronic currents; however, they influence them via changes in the charge density profile.
A comparative study of laryngeal view and pressor response by using three different blades- Macintosh, miller and Mccoy laryngoscopes (2019)

Maintenance of airway during anaesthesia is very important to anaesthesiologist. A prospective, randomized study was conducted in 90 patients (ASA-I & II) posted for various surgeries under general anaesthesia with endotracheal intubation to evaluate differences in glottic view, attempts and duration of laryngoscopy and intubation attempts along with hemodynamic variability associated with the three blades- Macintosh, McCoy and Miller laryngoscope blade. Patients were randomly allocated in three groups. In first group laryngoscopy was done with Macintosh blade, in second group with Miller blade, in third group with McCoy blade. In this study it was found that McCoy laryngoscope is distinctly superior to the Macintosh and Miller with less hemodynamic changes and better glottic visualization. Degree of difficulty in intubation was more with Miller blade in comparison to Macintosh and McCoy blade which is statistically significant (p value < 0> Keywords: Cormack lehane grade, Macintosh blade, McCoy blade, Miller blade, Degree of difficulty in intubation.
Verdrängende Arbeitsspeicher-Belegungsstrategie zur Durchsatzsteigerung von Rechenanlagen/ Throughput enhancement by adapted scheduling of working storage (1975)

Article Verdrängende Arbeitsspeicher-Belegungsstrategie zur Durchsatzsteigerung von Rechenanlagen/ Throughput enhancement by adapted scheduling of working storage was published on December 1, 1975 in the journal it - Information Technology (volume 17, issue 1-6).
Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology–Classified Systemic Lupus Erythematosus (2019)

Complement activation occurs in some patients with probable SLE and can be detected with higher frequency by evaluating CB-CAPs and MAP than by assessing traditional serum complement protein levels. A MAP score above 0.8 predicts transition to classifiable SLE according to ACR criteria.
Accelerated Progression of Kaolin-Induced Hydrocephalus in Aquaporin-4-Deficient Mice (2006)

Hydrocephalus is caused by an imbalance in cerebrospinal fluid (CSF) production and absorption, resulting in excess ventricular fluid accumulation and neurologic impairment. Current therapy for hydrocephalus involves surgical diversion of excess ventricular fluid. The water-transporting protein aquaporin-4 (AQP4) is expressed at the brain-CSF and blood-brain barriers. Here, we provide evidence for AQP4-facilitated CSF absorption in hydrocephalus by a transparenchymal pathway into the cerebral vasculature. A mouse model of obstructive hydrocephalus was created by injecting kaolin (2.5 mg/mouse) into the cisterna magna. Intracranial pressure (ICP) was approximately 5 mm Hg and ventricular size <0.3 mm(3) in control mice. Lateral ventricle volume increased to 3.7+/-0.5 and 5.1+/-0.5 mm(3) in AQP4 null mice at 3 and 5 days after injection, respectively, significantly greater than 2.6+/-0.3 and 3.5+/-0.5 mm(3) in wildtype mice (P<0.005). The corresponding ICP was 22+/-2 mm Hg at 3 days in AQP4 null mice, significantly greater than 14+/-1 mm Hg in wildtype mice (P<0.005). Brain parenchymal water content increased by 2% to 3% by 3 days, corresponding to approximately 50 muL of fluid, indicating backflow of CSF from the ventricle into the parenchymal extracellular space. A multi-compartment model of hydrocephalus based on experimental data from wildtype mice accurately reproduced the greater severity of hydrocephalus in AQP4 null mice, and predicted a much reduced severity if AQP4 expression/function were increased. Our results indicate a significant role for AQP4-mediated transparenchymal CSF absorption in hydrocephalus and provide a rational basis for evaluation of AQP4 induction as a nonsurgical therapy for hydrocephalus.
Undercooling measurement and nucleation study of silicon droplet solidification (2014)

The most efficient method to investigate nucleation phenomena is to measure the undercooling temperature at the beginning of the solidification process since it gives information about whether or not a certain substrate favors the heterogeneous nucleation. In this work a suitable experimental setup has been designed and developed for the study of nucleation phenomena, where a silicon droplet is directly placed and melted on a substrate. The melting‐solidification process was filmed and the undercooling temperature was simultaneously measured by monochromatic and bichromatic pyrometers. For all the studied substrates the melting process started from the bottom of the sample where there was a contact with the substrate. In the case of zyarock and fused silica substrates, on which we focalize in the present paper, the temperature profile of the silicon sample presented a temperature plateau during melting and a typical cooling curve showing undercooling, recalescence and a plateau denoting that solidification occurred under isothermal conditions. It was also found that the nature of the substrates influences the measured undercooling values and the shape of the solidified silicon droplets.
Repolarization Aiternans: Techniques, Mechanisms, and Cardiac Vulnerability (1997)

Sudden cardiac death continues to be the leading cause of mortality in developed countries. Electrical alternans of the ST segment and the T wave on the surface ECG as a noninvasive marker of patients at risk is a phenomenon that was initially observed early in this century and was seen then to be associated with cardiac rhythm disturbances. Substantial evidence indicates that T wave alternans (TWA) is related to myocardial ischemic as a harbinger of malignant ventricular arrhythmias because it reflects dispersion and heterogeneity of repolarization. Recent data have demonstrated a significant correlation between TWA and vulnerability to ventricular arrhythmias in individuals with or without organic heart disease, it also predicts the results of electrophysiological testing and arrhythmia-free survival in patients with a variety of cardiac diseases. This article reviews the historical background of TWA and discusses the early experimental and recent clinical evidence implying an integral link between TWA and ischemia-induced cardiac vulnerability.
A feedback-type adaptive array antenna for two-frequency duplex communications (2003)

A feedback type adaptive array antenna (AAA) system with wide element spacing is analyzed on the downlink channel of a frequency-division duplexed (FDD) cellular system. The AAA is installed on a base station so the downlink channel transfer functions are estimated and fed back on the uplink channel. The widely spaced AAA shows interference suppression as well as diversity effect against multipath fading. We also propose a scheme to apply our AAA system to the handoff mechanism. Moreover, we adopt an extrapolation technique for channel estimation. Computer simulation results showed that the AAA placed only at the base station can cope with cochannel interference and fading for the downlink when the fading speed is slow.
Destruction of monocrystalline silicon with nanosecond pulsed fiber laser accompanied by the oxidation of ablation microparticles (2013)

In this work, we report an observation of process of local destruction monocrystalline silicon with a scanning beam irradiation of pulse ytterbium fiber laser with a wavelength &lambda;= 1062 nm, accompanied by the oxidation of ablation microparticles. It is shown that depending on the power density of irradiation was observed a large scatter size of the microparticles. From a certain average power density is observed beginning oxidation particulate emitted from the surface of the irradiated area. By varying the parameters of the laser beam such as scanning speed, pulse repetition rate, overlap of laser spot, radiation dose can be achieved almost complete oxidation of all formed during the ablation of microparticles.