gebhart/patrepeval huggingface dataset:
La communication sous forme d’un jeu de plateau pour partager des données et des ressentis d’experts à propos d’un nouveau traitement contre le cancer (2019)

La conception de cartes à des fins de communication ou, de manière plus générale, la visualisation de données est un champ de recherches relativement ancien qui a subi de profonds changements au cours de ces dernières années. Si de nombreuses recherches y sont consacrées, très peu d’entre elles s’intéressent à une autre tendance forte du moment : l’emploi ou le détournement du jeu à des fins de communication. Ce papier traite de cette question en abordant le cas d’un support informationnel rappelant un jeu de stratégie sur plateau développé dans un but d’information à propos d’un nouveau procédé de lutte contre le cancer : la thérapie photodynamique.
Performance of 1-kHz KrF excimer laser for DUV lithography (1997)

In response to the requirement for higher wafer throughput and increased dosage accuracy in DUV lithography steppers and scanners, Cymer has developed a 1 kHz KrF laser optimized for this application. We shall describe its performance and design features.
Pyrazolidine derivatives: a comparative study of their effects on platelet aggregation. (1979)

Quantitative studies were carried out of the in vitro and ex vivo effects of phenylbutazone and 3-oxoalkyl substituted diphenyldioxopyrazolidines (kebuzone, tribuzone, benzopyrazone) on platelet aggregation. The specified pyrazolidine derivatives exhibited in vitro inhibitory effects on secondary platelet aggregation (induced by adrenaline and collagen), commensurable with the effects of sulfinpyrazone. The ex vivo efficacy was markedly influenced by the height of the drug level in blood and by differences in the elimination kinetics of the pyrazolidine derivatives in human organism. Inhibitory activities against primary aggregation (induced by ADP and thrombin) were found in vitro mainly in the phenyloxoalkyl derivative of diphenyldioxopyrazolidine (benzopyrazone) and its analogues. By substitution on the phenyl attached to its alkyl side chain (for example, by a halogen in the meta position), compounds were obtained which also possessed higher activities inhibiting secondary platelet aggregation.
Real‐world effectiveness for 12 weeks of ledipasvir–sofosbuvir for genotype 1 hepatitis C: the Trio Health study (2016)

Early data regarding the "real-world" experience with novel therapies for hepatitis C (HCV) are encouraging. Data are still limited, however, regarding real-world rates of sustained virologic response (SVR) for ledipasvir-sofosbuvir (LDV-SOF), particularly for patients with prior treatment failure. We performed a retrospective cohort study of 1597 patients with chronic genotype 1 HCV who were treated using 12 weeks of the following regimens LDV-SOF±ribavirin (RBV) (n=1521 without RBV, n=76 with RBV). The primary outcome was SVR-determined at 12 weeks in an intention-to-treat design. Prescription according to Food and Drug Administration (FDA) approved labelling (adding RBV for patients with cirrhosis and treatment failure) was assessed in multivariate models. The study population was aged 60 years on average (range 19-89), 60% male, 50% Caucasian, 43% cared for at an academic centre and 30% cirrhotic. Overall, LDV-SOF resulted in a 94% SVR rate. Only 44 (2.9%) patients relapsed. LDV-SOF+RBV yielded SVR in 97% with 0 viral relapses. While cirrhosis and thrombocytopenia were associated with lower odds of SVR, in a multivariable regression model, only treatment at an academic centre and prescriptions contrary to FDA labelling were significantly associated with lower SVR-odds ratios, 0.56 95% CI (0.35-0.87) and 0.29 95% CI(0.12-0.68), respectively. The real-world experience with LDV-SOF mirrors the SVR rates observed in clinical trials. Efforts to promote prescription within FDA recommendations are warranted.
Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres. Navarro-Mendoza et al (2019)

Supplementary material of the study "Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres" by Navarro-Mendoza et al. Centromeres are rapidly evolving across eukaryotes, despite performing a conserved function to ensure high fidelity chromosome segregation. CENP-A chromatin is a hallmark of a functional centromere in most organisms. Due to its critical role in kinetochore architecture, the loss of CENP-A is tolerated in only a few organisms, many of which possess holocentric chromosomes. Here, we characterize the consequence of the loss of CENP-A in the fungal kingdom. Mucor circinelloides, an opportunistic human pathogen, lacks CENP-A along with the evolutionarily conserved CENP-C, but assembles a monocentric chromosome with a localized kinetochore complex throughout the cell cycle. Mis12 and Dsn1, two conserved kinetochore proteins were found to colocalize to nine large scaffolds binding a short region comprised of an ~200-bp AT-rich sequence followed by a centromere-specific conserved motif that echoes the structure of budding yeast point centromeres. Resembling fungal regional centromeres, these core centromere regions are embedded in large genomic expanses devoid of genes yet marked by Grem-LINE1s, a novel retrotransposable element silenced by the Dicer-dependent RNAi pathway. Our results suggest that these hybrid features of point and regional centromeres arose from the absence of CENP-A, thus defining novel mosaic centromeres in this early-diverging fungus.
Solubilities of heavy hydrocarbons in compressed methane and nitrogen (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubilities of heavy hydrocarbons in compressed methane and nitrogenSaul G. D'Avila, Bal K. Kaul, and John M. PrausnitzCite this: J. Chem. Eng. Data 1976, 21, 4, 488–491Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/je60071a017https://doi.org/10.1021/je60071a017research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intrusion detection for wireless power networks, near-field communication, and side-channel attacks (2013)

Near-field approximations to Maxwell's equations reveal an interesting property of inductively-coupled links that are so frequently used in wireless power transfer: observation disturbs the system. We propose theoretical strategies and include preliminary practical implementations that demonstrate how this property can be used to detect presence of an adversary/intruder/eavesdropper, and thereby secure (a) wireless power transfer from power-stealing; (b) near-field information transfer; and (c) circuits from hardware probing attacks. These strategies rely on detecting the distortions in the electro-magnetic field induced by the presence of an extraneous element. We implement two of such circuits and compare them on their stability to detect such eavesdroppers.
An ultra-high-resolution offset-locked carbon dioxide laser spectrometer (1988)

An ultra-high-resolution frequency-offset-locked carbon dioxide waveguide laser spectrometer has been constructed. Three different sample cell configurations have been evaluated, namely: plane-plane etalon, mirror-based two-pass cell and a retro-reflector-based two-pass cell. In the last case peak-to-peak linewidths of 12 kHz have been obtained for the first derivative signal in sulphur hexafluoride at 10.6 mu m.
Molecular basis for dramatic changes in cannabinoid CB1 G protein‐coupled receptor activation upon single and double point mutations (2012)

There is considerable interest in determining the activation mechanism of G protein-coupled receptors (GPCRs), one of the most important types of proteins for intercellular signaling. Recently, it was demonstrated for the cannabinoid CB1 GPCR, that a single mutation T210A could make CB1 completely inactive whereas T210I makes it essentially constitutively active. To obtain an understanding of this dramatic dependence of activity on mutation, we used first-principles-based methods to predict the ensemble of low-energy seven-helix conformations for the wild-type (WT) and mutants (T210A and T210I). We find that the transmembrane (TM) helix packings depend markedly on these mutations, leading for T210A to both TM3+TM6 and TM2+TM6 salt-bridge couplings in the cytoplasmic face that explains the inactivity of this mutant. In contrast T210I has no such couplings across the receptor explaining the ease in activating this mutant. WT has just the TM3+TM6 coupling, known to be broken upon GPCR activation. To test this hypothesis on activity, we predicted double mutants that would convert the inactive mutant to normal activity and then confirmed this experimentally. This CB1 activation mechanism, or one similar to it, is expected to play a role in other constitutively active GPCRs as well.
Characterization of Hydrothermally Prepared Titanate Nanotube Powders by Ambient and In Situ Raman Spectroscopy (2009)

This letter reports on the successful synthesis of hydrogen titanate nanotubes (H−Ti-NT) and TiO2 (anatase) nanotubes and their thermal solid-state transformational chemistry and clarifies some of the confusion surrounding their literature Raman vibrational assignments. Hydrothermally prepared titanate nanotube powders with negligible (<0.1 wt % Na, H−Ti-NT) and high (∼7.0 wt % Na, Na/H−Ti-NT) Na content, that underwent freeze-drying and thermal treatments, were prepared and characterized with ambient and in situ Raman spectroscopy. The H−Ti-NT phase gives rise to Raman bands at ∼195, 285, 458, ∼700, 830, and 926 cm−1. The Raman bands above 650 cm−1 were found to be sensitive to the presence of moisture, which indicates that they are related to surface vibrational modes. The titanate nanotube Raman band at ∼926 cm−1 was shown not be related to a Na−O−Ti vibration, which was previously assigned in the literature, since its intensity does not vary with Na content, which varied by a factor of >70. The nanotubular H−Ti-NT phase was found to be thermally stabilized, <700 °C, by Na that had been entrapped during synthesis. The Na-free H−Ti-NT phase, however, transformed to TiO2 (anatase) nanotubes upon heating above 200 °C and was stable up to 700 °C.
Electrostatically balanced comb drive for controlled levitation (1990)

An experimental study of the levitation force, normal to the substrate, associated with interdigital capacitor electrostatic comb lateral actuators is reported. For compliant suspensions, normal displacements of over 2 mu m for a comb bias of 30 V were observed. This phenomenon is due to electrostatic repulsion by image charges mirrored in the ground plane beneath the suspended structure. By electrically isolating alternating drive-comb fingers and applying voltages of equal magnitude and opposite sign, levitation can be reduced by an order of magnitude while reducing the lateral drive force by less than a factor of two.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Combinatorial Control Required for the Specificity of Yeast MAPK Signaling (1997)

In yeast, an overlapping set of mitogen-activated protein kinase (MAPK) signaling components controls mating, haploid invasion, and pseudohyphal development. Paradoxically, a single downstream transcription factor, Ste12, is necessary for the execution of these distinct programs. Developmental specificity was found to require a transcription factor of the TEA/ATTS family, Tec1, which cooperates with Ste12 during filamentous and invasive growth. Purified derivatives of Ste12 and Tec1 bind cooperatively to enhancer elements called filamentation and invasion response elements (FREs), which program transcription that is specifically responsive to the MAPK signaling components required for filamentous growth. An FRE in the TEC1 promoter functions in a positive feedback loop required for pseudohyphal development.
Selective Catalytic Hydrodimerization of 1,3-Butadiene by Palladium Compounds Dissolved in Ionic Liquids (1998)

Palladium(II) compounds dissolved in 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMI·BF4) ionic liquid are shown to be able to catalyze the hydrodimerization of 1,3-butadiene. In most of the cases, only the 1,3-butadiene dimer 1,3,6-octatriene and the telomer octa-2,7-dien-1-ol have been obtained. The products' selectivity and catalytic activity depend on the reaction conditions. 1,3-Butadiene conversion up to 28%, a turnover frequency (TOF) of 118 h-1, and a selectivity of 94% on telomer were achieved with (BMI)2PdCl4 dissolved in BMI·BF4. The 1,3-butadiene conversion and TOF were significantly increased to 49% and 204 h-1, respectively, by a 5-atm pressure of carbon dioxide. The reactions were performed under homogeneous conditions at 70 °C. However, at temperatures below 5 °C, a two-phase system is formed and the products are easily removed from the reaction mixture by simple decanting. The recovered ionic catalyst solution can be reused several times without any significant changes in the catalytic performance. The structure of the new catalyst precursor (BMI)2PdCl4 has been determined by X-ray diffraction analysis.
Aromatization of 1‐Benzyltetrahydroisoquinolines: Racemization of (−)‐(S)‐(N‐nor)‐Reticuline (1981)

Abstract Aromatization in the series of optically active 1‐benzyltetrahydroisoquinolines has been accomplished with (—)‐( S )−( N ‐nor)‐reticuline ( 1b ) and analogs. Direct catalytic or chemical reduction of the isoquinoline 4 obtained could not be achieved in a practical way but 4 was converted into 1 in three steps ( 4 → 8 → 9 → 1 ), in 55% overall yield. Partial O ‐methylation of the isoquinoline 4 gave the isoquinoline alkaloid palaudine ( 5 ), before papaverine ( 6 ) was formed.
Small population effects and hybridization (2008)

This paper examines the confluence of two lines of research that seek to improve the performance of evolutionary computation systems through management of information flow. The first is hybridization; the second is using small population effects. Hybridization consists of restarting evolutionary algorithms with copies of best-of-population individuals drawn from many populations. Small population effects occur when an evolutionary algorithmpsilas performance, either speed or probability of premature convergence, is improved by use of a very small population. This paper presents a structure for evolutionary computation called a blender which performs hybridization of many small populations. The blender algorithm is tested on the PORS and Tartarus tasks. Substantial and significant effects result from varying the size of the small populations used and from varying the frequency with which hybridization is performed. The major effect results from changing the frequency of hybridization; the impact of population size is more modest. The parameter settings which yield best performance of the blender algorithm are remarkably consistent across all seven sets of experiments performed. Blender performance is found to be superior to other algorithms for six cases of the PORS problem. For Tartarus, blender performs well, but not as well as the previous hybridization experiments that motivated its development.
Almanya’da Kütüphanecilik Eğitimi (2004)

Son yıllarda yaşanan teknolojik gelişmeler, kütüphanecilik mesleğinin değişime uğramasına yol açmıştır. Gerek bilgi uzmanlarının mesleklerini algılama biçimi, gerekse meslek mensuplarında bulunması gerekli olan nitelik ve yetenekler değiş­miş ve çeşitlenmiştir. Bunun doğal bir sonucu olarak, kütüphanecilik eğitimi de değişime uğramıştır ve uğramaktadır. Bu makalede Almanya’daki kütüphaneci­lik eğitimi konusunda yaşanan değişimler, gelişmeler ve yeni eğilimler üzerinde durulmaktadır.
Consumer Demand, Grades, Brands, and Margin Relationships - eScholarship (1980)

CUDARE Division of Agricultural Sciences UNIVERSITY OF CALIFORNIA LUniversity of Califomia, Berkeley. Dept. of agricultural and resource economic~ Working Paper Working Paper No. 123 CONSUMER DEt\1Al\ffi, GRADES, BRANDS, A~TI ~~GIN RELATIONSHIPS Peter Berck and Gordon C. Rausser »:AMN:M ~ P()tfN't)f<;1:1C~cN .~~~~~~n~'ru;,xr t. .::c-' r!CON()M.t<;$ U~~~;WI1 California Agricultural Experiment Station Giannini Foundation of Agricultural Economics July 1980
Data from A Systematic Comparison of <sup>18</sup>F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; An early readout of tumor response to therapy through measurement of drug or radiation-induced cell death may provide important prognostic indications and improved patient management. It has been shown that the uptake of &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT can be used to detect early response to therapy in tumors by positron emission tomography (PET) via a mechanism of caspase-3–triggered nanoaggregation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Here, we compared the preclinical utility of &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT for the detection of drug-induced cell death to clinically evaluated radiotracers, &lt;sup&gt;18&lt;/sup&gt;F-FDG, &lt;sup&gt;99m&lt;/sup&gt;Tc-Annexin V, and &lt;sup&gt;18&lt;/sup&gt;F-ML-10 in tumor cells in culture, and in tumor-bearing mice &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In drug-treated lymphoma cells, &lt;sup&gt;18&lt;/sup&gt;F-FDG, &lt;sup&gt;99m&lt;/sup&gt;Tc-Annexin V, and &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT cell-associated radioactivity correlated well to levels of cell death (&lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; &gt; 0.8; &lt;i&gt;P&lt;/i&gt; &lt; 0.001), with no correlation measured for &lt;sup&gt;18&lt;/sup&gt;F-ML-10 (&lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.05; &lt;i&gt;P&lt;/i&gt; &gt; 0.05). A similar pattern of response was observed in two human NSCLC cell lines following carboplatin treatment. EL-4 tumor uptake of &lt;sup&gt;99m&lt;/sup&gt;Tc-Annexin V and &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT were increased 1.4- and 2.1-fold, respectively, in drug-treated versus naïve control animals (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), although &lt;sup&gt;99m&lt;/sup&gt;Tc-Annexin V binding did not correlate to &lt;i&gt;ex vivo&lt;/i&gt; TUNEL staining of tissue sections. A differential response was not observed with either &lt;sup&gt;18&lt;/sup&gt;F-FDG or &lt;sup&gt;18&lt;/sup&gt;F-ML-10.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; We have demonstrated here that &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT can sensitively detect drug-induced cell death in murine lymphoma and human NSCLC. Despite favorable image contrast obtained with &lt;sup&gt;18&lt;/sup&gt;F-C-SNAT, the development of next-generation derivatives, using the same novel and promising uptake mechanism, but displaying improved biodistribution profiles, are warranted for maximum clinical utility. &lt;i&gt;Clin Cancer Res; 21(17); 3896–905. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
SELECTIVE T-CELL-RECEPTOR GENE USAGE IN ALLORECOGNITION AND GRAFT-VERSUS-HOST DISEASE (1993)

Immune recognition of foreign HLA molecules is initiated by T cell recognition mediated by alloreactive T cell receptor (TCR) molecules. We analyzed the diversity of TCR expression in the clinical setting of allorecognition in a patient with acute graft-versus-host disease following bone marrow transplantation. Nearly 200 TCR transcripts from peripheral blood lymphocytes were cloned and sequenced at two time points during GVHD. HLA genes in the transplant donor and the recipient were mismatched for a very specific HLA-DR subtype: HLA-DRB1 genes in the donor (DR4/Dw4) and the recipient (DR4/Dw14) encode HLA molecules that differ at only two amino acids, providing a very restricted target for allorecognition. We also studied TCR genes from five T cell clones derived in vitro from mixed lymphocyte cultures between Dw4-positive responder and Dw14-positive stimulator cells. Comparisons of the derived TCR sequences implicate nonrandom patterns of TCR selection both in vivo and in vitro.
Liquid-Fed Electromagnetic Accelerator for Nanosatellite Applications (2020)

This paper summarizes the design and preliminary characterization of a liquid-fed pulsed-plasma accelerator (LF-PPT) with a novel low-energy flashover igniter. A dielectric fluid was utilized as a propellant – pentaphenyl trimethyl trisiloxane (C33H34O2Si3). A 3μF / 2kV capacitor bank, offering shot energies of < 6 J, supported current pulse durations of ~ 16μs with observed peaks of 7.42 kA. Time of flight measurements were conducted using a biased double probe assembly, suggesting an exhaust velocity of ~32 km/s. Intensified charge coupled device (ICCD) photography was concurrently leveraged to visualize plasma dynamics and mechanisms of the acceleration event.
Biodisponibilité comparée de trois sources de calcium : carbonate et sulfate de calcium et calcium de lait (1999)

Poster *INRA, Laboratoire de Nutrition et Sécurité Alimentaire, Jouy en Josas (FRA) Diffusion du document : INRA, Laboratoire de Nutrition et Sécurité Alimentaire, Jouy en Josas (FRA)
Guidelines for Guardrail Implementation (2009)

This report provides guidance on selecting the appropriate barrier performance level for the installation of longitudinal barriers. The report presents performance-level selection guidelines to help designers determine the most appropriate guardrail test level for any route. Further, site-specific guidelines not only identify what guardrail test level should be incorporated but also can be used to determine when guardrail use is not cost beneficial. Supplemental procedures for identifying appropriate guardrail test levels have also been developed. These procedures expand the applicability of the guardrail selection guidelines to many unusual hazards that cannot be included in development of general procedures. The report will be of particular interest to designers with responsibility for designing roadside safety features.
PHYSIOLOGICAL RESPONSES OF ADOLESCENT COMPETITIVE SWIMMERS TO MAXIMAL EXERCISE (1986)

Dept. of Exercise Science, Alma College, Alma, MI, 48801 and Dept. of Physiology, SUNY - Buffalo, Buffalo, NY 14214.
Hynic-modified somatostatin analogs labelled with technetium-99m (2000)

s: Abstracts of an International Conference on Peptide Radiopharmaceuticals in Diagnosis and Therapy Rome, Italy, 25-28 May 2000: Poster Presentations
Tailoring the dispersion behavior of silicon nanophotonic slot waveguides (2010)

We investigate the chromatic dispersion properties of silicon channel slot waveguides in a broad spectral region centered at ~1.5 μm. The variation of the dispersion profile as a function of the slot fill factor, i.e., the ratio between the slot and waveguide widths, is analyzed. Symmetric as well as asymmetric geometries are considered. In general, two different dispersion regimes are identified. Furthermore, our analysis shows that the zero and/or the peak dispersion wavelengths can be tailored by a careful control of the geometrical waveguide parameters including the cross-sectional area, the slot fill factor, and the slot asymmetry degree.