gebhart/patrepeval huggingface dataset:
Semliki forest virus entry and the endocytic pathway (1984)

Conference Article| December 01 1984 Semliki forest virus entry and the endocytic pathway MARK MARSH; MARK MARSH 1Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar MARGARET C. KIELIAN; MARGARET C. KIELIAN 2Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar ARI HELENIUS ARI HELENIUS 3Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (6): 981–983. https://doi.org/10.1042/bst0120981 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation MARK MARSH, MARGARET C. KIELIAN, ARI HELENIUS; Semliki forest virus entry and the endocytic pathway. Biochem Soc Trans 1 December 1984; 12 (6): 981–983. doi: https://doi.org/10.1042/bst0120981 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: SFV, Semliki Forest virus, BHK, baby hamster kidney, RNase, ribonuclease, HRP, horseradish peroxidase This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Reductive Cyclization of 2‐Nitro‐ and β‐Nitrostyrenes, 2‐Nitrobiphenyls, and 1‐Nitro‐1,3‐Dienes to Indoles, Carbazoles, and Pyrroles (2022)

This chapter presents a comprehensive review of reductive cyclizations of 2‐nitro‐ and β‐nitrostyrenes, 2‐nitrobiphenyls, and 1‐nitro‐1,3‐dienes to furnish indoles, carbazoles, and pyrroles, respectively, as well as heteroatom analogs thereof. Two variations of the reductive cyclization are discussed: the Cadogan–Sundberg reaction, which is mediated by ternary phosphorus compounds, and the Watanabe–Cenini–Söderberg reaction, which employs a palladium catalyst in the presence of carbon monoxide. A few closely related reductive cyclizations are also presented, as are comparisons with other cyclizations that form the nitrogen–carbon bond of indoles and derivatives.
In-vitro fertilization and embryo transfer in women aged 40 years and over (1996)

The decline of fertility with age and its possible causes are discussed; in particular the effect of ageing of oocytes and the uterus, and the effect of the ageing processes on the results of in-vitro fertilization (IVF) and embryo transfer in women aged > or =40 years. The role of prestimulation testing in older women is considered together with the importance of screening and counselling these patients about the likelihood of achieving a live birth. The potential problems that they may face should they become pregnant are reviewed, together with the role of oocyte donation as an alternative treatment for patients with reduced ovarian reserve. Possible ways of improving the chances of achieving a live birth in older women using their own oocytes are reviewed, including the use of more effective stimulation protocols, assisted embryo hatching and co-culture and high order embryo transfer. The outcome of pregnancies in older women and some of the ethical problems relating to their treatment are also discussed.
Development and application of a new semiconductive glaze insulator (1975)

A new semiconductive glaze insulator with superior glaze and greatly improved contamination performance has been developed for use in vertical and V-string positions. This insulator makes it possible to convert many existing lines to operation at higher voltages and to design new lines with greatly reduced tower head dimensions.
Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function (2010)

Hematopoietic stem (HSC) and progenitor (HPC) cell fate is governed by intrinsic and extrinsic parameters. We examined the impact of hematopoietic niche elements on HSC and HPC function by analyzing the combined effect of osteoblasts (OBs) and stromal cells (SCs) on Lineage(-)Sca-1(+)CD117(+) (LSK) cells. CFU expansion and marrow repopulating potential of cultured Lineage(-)Sca-1(+)CD117(+) cells were significantly higher in OB compared with SC cultures, thus corroborating the importance of OBs in the competence of the hematopoietic niche. OB-mediated enhancement of HSC and HPC function was reduced in cocultures of OBs and SCs, suggesting that SCs suppressed the OB-mediated hematopoiesis-enhancing activity. Although the suppressive effect of SC was mediated by adipocytes, probably through up-regulation of neuropilin-1, the OB-mediated enhanced hematopoiesis function was elaborated through Notch signaling. Expression of Notch 2, Jagged 1 and 2, Delta 1 and 4, Hes 1 and 5, and Deltex was increased in OB cultures and suppressed in SC and OB/SC cultures. Phenotypic fractionation of OBs did not segregate the hematopoiesis-enhancing activity but demonstrated that this function is common to OBs from different anatomic sites. These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs.
Introduction (2014)

A couple of years ago we were teaching cross-cultural management to MBA students at an international business school when a student came up to us and said, 'It's been an interesting class, but you have to hurry up in making money, because you will be out of a job soon.' When we asked him why, he said that the cultures of the world are becoming more and more alike. Wherever he travelled he would find the same type of hotels and the same type of food; the people he met were all connected to the internet and all looked forward to the launch of the next version of the iPhone.KeywordsPerformance GoalDiversity ManagementIntercultural CommunicationHuman Resource DepartmentIntercultural CompetenceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Nonlinear optics in fibers for fiber measurements and special device functions (1986)

Nonlinear optical effects in fibers are significant in three respects. They present undesirable transmission limitations for long-distance optical fiber communication systems due to the intensity-dependent loss and pulse waveform distortions. On the useful side, they provide efficient frequency conversion means for generating frequency-shifted optical sources for a variety of spectroscopic applications including optical fiber measurements and optical device characterization. In addition, nonlinear optical effects also can provide useful special optical device functions such as optical amplification, optical gating, optical pulseshaping, and waveform equalization. This paper gives a brief review of the latter two aspects of nonlinear optics in fibers.
Effects of the individual isomers cis‐9,trans‐11 vs. trans‐10,cis‐12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL‐phenotype B (2005)

Immune-modulating effects of CLA have been reported in animals, but results are inconsistent. In humans, CLA has shown no effects or only minor effects on immune function. The objective of this study was to evaluate the immune-modulating effects of 3 g cis-9,trans-11 (c9,t11) vs. trans-10,cis-12 (t10,c12) CLA isomers in a population with a high risk of coronary heart disease characterized by moderate overweight (body-mass index, 25-32.5 kg/m2) in combination with LDL-phenotype B (> or = 35% small LDL cholesterol, density > or = 1.040 g/mL). After a run-in period of 1 wk, 42 men and women were randomly allocated to the c9,t11 CLA group, the t10,c12 CLA group, or the placebo group. Effects of 13 wk of consumption of 3 g of CLA isomers on cytokine production by ex vivo lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMC) and whole blood, and on plasma C-reactive protein (CRP) concentrations were evaluated. To generate hypotheses for future studies, protein expression patterns of 42 cytokines, chemokines, and growth factors were evaluated with an antibody array in pooled, nonstimulated, fasting plasma samples. LPS induced interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha production by PBMC, and whole blood as well as plasma CRP concentrations were not significantly changed by the c9,t11 and the t10,c12 CLA isomers. The cytokine expression profile in nonstimulated plasma suggested that both CLA isomers induced a specific inflammatory signature, in which the c9,t11 CLA group showed more activity in terms of numbers of proteins regulated. We conclude that daily consumption of 3 g of c9,t11 or t10,c12 CLA isomer did not affect LPS-stimulated cytokine production by PBMC or whole blood and plasma CRP levels. Inflammatory signatures in fasting, nonstimulated plasma as determined by an antibody array may indicate enhanced immune function by both CLA isomers.
Clinical safety and effectiveness of the Genoss drug-eluting stent in real-world clinical practice (2023)

In this real-world registry, the Genoss DES™ demonstrated excellent safety and effectiveness at 12 months among all-comer patients undergoing percutaneous coronary intervention. These findings suggest that the Genoss DES™ may be a viable treatment option for patients with coronary artery disease.
Fever of unknown origin (2003)

Fever of unknown origin (FUO) remains a challenging clinical problem despite recent advances in diagnostic tools and techniques. Because primary care physicians are often the first ones to encounter a case of FUO, it is important that they be familiar with the best strategy and steps for confronting this problem initially. Here, Drs Amin and Kauffman review the major causes of FUO in adults and describe an in-depth approach to laboratory and radiologic tests that help establish a diagnosis.
Mobile Twin Recognition (2020)

This study focused on one of the most advanced problems in facial recognition - twin differentiation. In recent years, an increasing number of mobile phones have been hacked using the face of the phone owner's sibling/twin, and there are hundreds of videos about this available on the internet. Our main goal is to improve mobile security and protect user data from outside interventions, and therefore we propose a technique which helps to recognize twins to the same extent as humans are able to do so. The main idea involves combining a modern convolutional neural network (CNN) approach with classical handcrafted features, which describe particular characteristics of the human face, such as an asymmetry. Our method was optimized for low performance mobile platforms and it can be simply used by any system with limited resources.
Alicyclic Studies. XIII.1 Preparation and Reactions of 1,1'-Dicycloalkenyls* (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlicyclic Studies. XIII.1 Preparation and Reactions of 1,1'-Dicycloalkenyls*DAHLIA SHIMONA GREIDINGER and DAVID GINSBURGCite this: J. Org. Chem. 1957, 22, 11, 1406–1410Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/jo01362a026https://doi.org/10.1021/jo01362a026research-articleACS PublicationsRequest reuse permissionsArticle Views258Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Realising Variability in Dynamic Software Product Line Solutions (2018)

Modern systems need to be able to self-adapt to changes in user needs, and changes affecting the system itself or its environment. Dynamic software product line (DSPL) is an engineering approach for developing self-adaptive systems based on commonalities and variabilities for a family of similar systems. Currently, many DSPL approaches fail to meet all adaptability requirements, and in many cases, they are developed in a such unstructured manner that the controller is not explicitly represented, for example. We specify a two-dimension taxonomy to address basic technical issues for realising variability in DSPLs. The self-adaptation dimension classifies the different design choices for the adaptability requirements. The DSPL variability dimension classifies different design choices for implementing variability schemes and for creating different kinds of feature models. Our study was substantiated by surveying several DSPL approaches, and evaluating and comparing their different design strategies. We also summarise practical issues and difficulties, identify major trends in actual DSPL proposals, and suggest directions for future.
Количественный анализ уровней риска на основе универсальной бинарной модели предпочтения лицом, принимающим решение (ЛПР) (2009)

Исследуются возможности количественного анализа уровня рисков на основе универсальной шкалы комплексного оценивания, вследствие чего выдвигается конструктивный подход к построению иерархических моделей многофакторных рисков с целью расширения функциональных возможностей.
A Coriolis mass flow sensor structure in silicon (2002)

The first mass flow sensor in silicon based on the Coriolis force principle is presented. The basic sensor structure consists of a double-loop tube structure in silicon which can also be used for measurement of fluid density. The tube structure is excited electrostatically in a bending or torsion vibration mode. A liquid mass flow induces a Coriolis force which results in a tube twisting angular motion. The Coriolis angular motion is linearly proportional to the mass-flow and is detected optically. The measurement results show good, true mass flow direction sensitivity with high linearity in the investigated flow range below 0.5 g/s.
Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art (2021)

The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches.
The Effects of Electron Beam Exposure Time on Transmission Electron Microscopy Imaging of Negatively Stained Biological Samples (2015)

Negative staining electron microscopy facilitates the visualization of small bio-materials such as proteins; thus, many electron microscopists have used this conventional method to visualize the morphologies and structures of biological materials. To achieve sufficient contrast of the materials, a number of imaging parameters must be considered. Here, we examined the effects of one of the fundamental imaging parameters, electron beam exposure time, on electron densities generated using transmission electron microscopy. A single site of a negatively stained biological sample was illuminated with the electron beam for different times (1, 2, or 4 seconds) and sets of micrographs were collected. Computational image processing demonstrated that longer exposure times provide better electron densities at the molecular level. This report describes technical procedures for testing parameters that allow enhanced evaluations of the densities of electron microscopy images.
Control of the Synthesis of Phosphoenolpyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase in Escherichia coli* (1970)

The level of phosphoenolpyruvate (PEP) carboxylase (EC 4. 1. 1. 31) in Escherichia coli W was remarkably affected by the carbon source in the growth medium. The enzyme level was found to decrease in the following order: glucose>glycerol>malate>lactatc>acetate>aspartate. Several lines of evidence support that PEP carboxylase is nutritionally induced by glucose bur not repressed by any compound related to the tricarboxylic acid cycle. The level of PEP carboxykinase [EG 4. 1. 1. 49] in-the cells grown on malate-, aspartate-, or enriched media was 4- to 7-fold higher than that on glucose media. The synthesis of PEP carboxykinase was presumed to be nutritionally repressed by glucose. In view of the antagonistic behaviors of these two enzymes in the cells grown on various carbon sources, the syntheses of both enzymes seem to be inversely regulated each other. The regulatory mechanism concerned in the syntheses of these two physiologically antagonistic enzymes was supposed to play an important role in the metabolic shift from glycolysis to gluconeogenesis, or vice versa.
NLIZE: A Perturbation-Driven Visual Interrogation Tool for Analyzing and Interpreting Natural Language Inference Models (2018)

With the recent advances in deep learning, neural network models have obtained state-of-the-art performances for many linguistic tasks in natural language processing. However, this rapid progress also brings enormous challenges. The opaque nature of a neural network model leads to hard-to-debug-systems and difficult-to-interpret mechanisms. Here, we introduce a visualization system that, through a tight yet flexible integration between visualization elements and the underlying model, allows a user to interrogate the model by perturbing the input, internal state, and prediction while observing changes in other parts of the pipeline. We use the natural language inference problem as an example to illustrate how a perturbation-driven paradigm can help domain experts assess the potential limitation of a model, probe its inner states, and interpret and form hypotheses about fundamental model mechanisms such as attention.
Subunit dissociation in the allosteric regulation of glycerol kinase from Escherichia coli. 1. Kinetic evidence (1978)

The dependence of the molecular weight of glycerol kinase on enzyme concentration and on binding of fructose 1,6-bisphosphate has been examined by velocity sedimentation, gel filtration, and polyacrylamide gel electrophoresis. The sedimentation coefficient and Stokes radius decrease as a consequence of dilution in a manner consistent with dissociation into half-molecules, with limiting values suggesting molecular weights of about 218,000 and 136,000 for the associated and dissociated species, respectively. Fructose 1,6-bisphosphate (5 mM) prevents the decrease in sedimentation coefficient brought about by dilution, suggesting a decrease in the apparent subunit dissociation constant of at least four orders of magnitude. Electrophoretic mobility in polyacrylamide gels increases as a consequence of dilution in the absence, but not in the presence, of fructose 1,6-bisphosphate. Ferguson plots indicate that glycerol kinase has the same molecular weight in the presence of fructose 1,6-bisphosphate as the covalently cross-linked tetramer and is substantially smaller in the absence of fructose 1,6-bisphosphate. These results are consistent with the model of glycerol kinase proposed in the preceding paper of this issue [de Riel, J.K., and Paulus, H. (1978), Biochemistry 17] relating subunit dissociation and ligand binding.
Building integration of an amorphous silicon photovoltaic facade (2002)

A large photovoltaic facade was retrofitted to an industrial building complex of the Joint Research Centre. Amorphous silicon technology was chosen to cover the maximum possible area at a minimum of costs. The a-Si substrates are laminated within a double-glass facade element. Total area of the facade is 770 m/sup 2/, probably the largest PV facade in operation. Total power output fed into the grid is approximately 25 kWp after stabilisation. Emphasis was put on the architectural design and the visualisation of the function of the system to a wider public by an interactive user-display.
A101 Multiple Electrostatic Suspension Systems : 4th report: Experimental study on dynamic characteristics of a double suspension system (2011)

Multiple electrostatic suspension suspends multiple floator with a single power amplifier. The controllability of the parallel-connected double suspension system was previously analyzed, and the conditions to be controllable were shown. To test the analytical results, 1-DOF suspension systems were fabricated, and they composed a parallel-connected double electrostatic suspension system. The feasibility of double electrostatic suspension was demonstrated experimentally. This paper showed a basic model of proposed system, the controllability, and the realization of double electrostatic suspension with the fabricated suspension system. Dynamic characteristics of double electrostatic suspension was researched based on frequency responses.
Please Turn Your Cameras On: Remote Onboarding of Software Developers\n during a Pandemic (2020)

The COVID-19 pandemic has impacted the way that software development teams\nonboard new hires. Previously, most software developers worked in physical\noffices and new hires onboarded to their teams in the physical office,\nfollowing a standard onboarding process. However, when companies transitioned\nemployees to work from home due to the pandemic, there was little to no time to\ndevelop new onboarding procedures. In this paper, we present a survey of 267\nnew hires at Microsoft that onboarded to software development teams during the\npandemic. We explored their remote onboarding process, including the challenges\nthat the new hires encountered and their social connectedness with their teams.\nWe found that most developers onboarded remotely and never had an opportunity\nto meet their teammates in person. This leads to one of the biggest challenges\nfaced by these new hires, building a strong social connection with their team.\nWe use these results to provide recommendations for onboarding remote hires.\n