gebhart/patrepeval huggingface dataset:
Efficacy and Resistance of ALK Inhibitors in Two Inflammatory Myofibroblastic Tumor Patients with ALK Fusions Assessed by Whole Exome and RNA Sequencing (2020)

Chenlu Zhang,1 Zhiming Wang,1 Rongyuan Zhuang,1 Xi Guo,1 Yi Feng,1 Feng Shen,1 Wenshuai Liu,2 Yong Zhang,3 Hanxing Tong,3 Wending Sun,4 Jun Liu,4 Guan Wang,4 Chun Dai,4 Weiqi Lu,3 Yuhong Zhou1 1Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, People&amp;amp;rsquo;s Republic of China; 2Department of General Surgery, Shanghai Public Health Clinical Center, Shanghai, People&amp;amp;rsquo;s Republic of China; 3Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People&amp;amp;rsquo;s Republic of China; 4GenomiCare Biotechnology Co. Ltd, Shanghai, People&amp;amp;rsquo;s Republic of ChinaCorrespondence: Weiqi LuDepartment of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, People&amp;amp;rsquo;s Republic of ChinaEmail lu.weiqi@zs-hospital.sh.cnYuhong ZhouDepartment of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, People&amp;amp;rsquo;s Republic of ChinaEmail zhou.yuhong@zs-hospital.sh.cnAbstract: We report two inflammatory myofibroblastic tumor (IMT) patients with ALK fusions (RRBP-ALK and TNS1-ALK, respectively). They both received tumor resection surgery and treatment with ALK inhibitors crizotinib followed by alectinib, and upon receiving each of the drugs, showed a brief response, then experienced recurrence or progression of the disease. During the treatment, whole exome sequencing (WES) and RNA sequencing (RNA-Seq) were applied to monitor potential drug-induced gene mutation and expression changes. A novel, secondary mutation in ALK exon 23 (L1196Q) was identified in patient 1 after alectinib resistance developed. Guided by this result, a newer ALK inhibitor, ceritinib was prescribed. The patient was able to achieve a partial response (PR) and is in good condition as of the manuscript date. On the contrary, there was no secondary mutation identified in ALK in patient 2 after drug resistance. While the expression of PTCH1, a negative regulator of the sonic hedgehog (SHH) signaling pathway, was significantly reduced at the time after the treatment with crizotinib before that of alectinib. The expression of PTCH1 was also reduced after the treatment with alectinib. It was reported that ALK can exert its biological functions partially by activating SHH signaling pathway. The down-regulation of PTCH1 suggests the compensatory activation of SHH pathway may cause resistance to ALK inhibitors in IMT. Going forward, monitoring gene mutation and expression changes through DNA and RNA sequencing will be able to offer opportunities to investigate potential mechanisms of drug resistance and will help to achieve precise prescription for better treatment outcomes.Keywords: inflammatory myofibroblastic tumor, crizotinib resistance, alectinib resistance, ALK L1196Q, sonic hedgehog pathway
An Intelligent, Free-Flying Robot (1988)

The ground-based demonstration of EVA Retriever, a voice-supervised, intelligent, free-flying robot, is designed to evaluate the capability to retrieve objects (astronauts, equipment, and tools) which have accidentally separated from the Space Station. The major objective of the EVA Retriever Project is to design, develop, and evaluate an integrated robotic hardware and on-board software system which autonomously: (1)performs system activation and check-out, (2)searches for and acquires the target, (3)plans and executes a rendezvous while continuously tracking the target, (4)avoids stationary and moving obstacles, (5)reaches for and grapples the target, (6)returns to transfer the object, and (7)returns to base.
Slow Diffusion of Macromolecular Assemblies Measured by a New Pulsed Field Gradient NMR Method [J. Am. Chem. Soc. 2003, 125, 2541−2545]. (2004)

On page 2543, the bipolar scheme uses two gradient pulses for encoding, and two other gradient pulses for decoding. Thus, Equation 1 should be S/S0 = exp{-D4k2(D + 6t)}, rather than S/S0 = exp{-Dk2(D + 6t)}, as published. The incorrect expression would lead to an overestimation of the diffusion coeff. D by a factor of 4. This correction does not affect the results shown in Figure 3 or the diffusion coeffs. quoted in the paper. [on SciFinder (R)]
Supplementary Data from SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma (2023)

Supplementary Data from SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
Vision-based tracking method to multiple interacting targets (2010)

In this paper, we introduce a method of moving insects tracking. Our method is robust image processing to change of illumination under orientation code matching. Further, based on extended Kalman filter, it can track moving insects which are doing the random motion. Through experiments, this paper shows the effectiveness of proposed method.
Geometric phase analysis of high-resolution electron microscopy images of antiphase domains: Example Cu3Au (1997)

Abstract A new method for analysing antiphase domains using high-resolution electron micrographs is described. A high-resolution electron microscope image taken at a zone axis is treated as the sum of many sets of interference fringes. The analysis extracts the information concerning the variations in the image periodicities as a function of position. In particular, the amplitude and phase variations of these fringes are analysed separately. The amplitude images reveal the antiphase boundaries in a similar way to a conventional dark-field experiment whilst the phase produces images of the translation domains and defines the associated translation vectors. The phase variations can also be related to the strain field associated with the corresponding lattice planes. Experimental images of antiphase boundaries in Cu3Au taken at [001] are used to demonstrate the technique. Antiphase boundaries perpendicular and parallel to the electron beam are characterized. The phase images are used to characterize disordered regions where the domains were too small to be analysed by a dark-field method. A quantitative criterion is proposed for distinguishing between a structural model based on homogeneous short-range order and a model based on microdomains. For the experimental case studied, it is shown that the image contrast cannot be explained purely in terms of homogeneous short-range order and that a microdomain-type model is more appropriate.
Computational performance of level set methods for etching, deposition, and lithography development (2005)

The application of level set techniques to problems of two and three dimensional surface evolution in etching, deposition, and lithography development have been described. The techniques are robust, accurate, unbreakable, and extremely fast, and can be applied to highly complex two and three dimensional surface topography evolutions, including sensitive flux/visibility integration laws, simultaneous etching and deposition, effects of non-convex sputter laws demonstrating faceting, as well as ion-sputtered re-deposition and re-emission with low sticking coefficients, and surface diffusion. In this paper, we will focus on efficient algorithms for some of the most complex problems, and discuss the computational requirements and performance of these techniques.
Ultrasensitive Prostate Specific Antigen after Prostatectomy Reliably Identifies Patients Requiring Postoperative Radiotherapy (2014)

Ultrasensitive prostate specific antigen 0.03 ng/ml or greater is an independent factor that identifies biochemical relapse more accurately than any traditional risk factors and confers a significant lead time advantage. This factor enables critical decisions on the timing of and indication for postoperative radiotherapy in patients at high risk after radical prostatectomy.
An iterative greedy algorithm for scheduled traffic grooming in wdm optical networks (2007)

Routing and wavelength allocation (RWA) in translucent WDM optical networks aims at optimizing network's resources utilization. Traffic grooming, traffic rerouting, wavelength conversion and regenerator placement are some of the key operations enabling such an optimization. Two types of traffic grooming are considered in WDM networks, either optical or electrical. In this paper, we propose an innovative greedy iterative algorithm enabling to aggregate in the electrical domain scheduled traffic demands in order to favors a better bandwidth utilization of the optical channels to be set-up in the network. For a same set of traffic scenarios, we compare the cost of the resources required in the network, either by means of our algorithm or by means of two other greedy iterative algorithms recently proposed in the literature. The optical fiber infrastructure being installed, we consider the network cost as proportional to the global number of required optical ports and electrical ports at the various switching nodes.
Updated results: A phase I/IIa randomized trial of radium-223 + docetaxel versus docetaxel in patients with castration-resistant prostate cancer and bone metastases. (2016)

5075 Background: Radium-223 (Ra-223), an α emitter, and docetaxel (D), a chemotherapy, prolong overall survival (OS) in metastatic castration-resistant prostate cancer (CRPC) patients (pts). This study examined safety and efficacy of Ra-223 + D v D alone. Preliminary phase IIa prostate-specific antigen (PSA) and alkaline phosphatase (ALP) data were previously reported (Morris et al. ASCO 2015). All pts have been randomized and have completed treatment. Methods: D-eligible pts with progressing CRPC and ≥ 2 bone metastases were randomized 2:1 to Ra-223 (50 kBq/kg q 6 wk × 5) + D (60 mg/m2 q 3 wk × 10) v D (75 mg/m2 q 3 wk × 10; step-down option to 60 mg/m2). Primary end point was safety; exploratory efficacy end points were PSA and ALP changes, progression-free survival (PFS), and OS. Results: 53 pts (36 Ra-223 + D; 17 D) were randomized; 33 Ra-223 + D and 13 D pts were treated. For pts in the Ra-223 + D arm, 25 (76%) had all 6 Ra-223 injections, and 20 (61%) had all 10 D cycles. For the D-alone pts, 5 (38%) received all 10 cycles (3 received 75 mg/m2, and 2 stepped down to 60 mg/m2). Pts in Ra-223 + D arm had a lower percentage of grade 3/4 treatment-emergent adverse events during treatment (Ra-223 + D, 49%; D, 62%); no Ra-223 + D and 2 (15%) D pts had febrile neutropenia; no pts had clinically significant thrombocytopenia in either arm. Ra-223 + D had longer time to all measures of progression and longer PFS (Table). Waterfall plots of PSA and ALP will be presented. Two Ra-223 + D pts and one D pt died of disease progression during 9-mo follow-up. Conclusions: Ra-223 + D was well tolerated. Ra-223 + D treated pts had longer times to progression and fewer adverse events v pts in D arm. Further studies of Ra-223 + D are planned. Clinical trial information: NCT01106352. Median, mo (95% CI); number of pts with events Ra-223 + D N = 32 D N = 13 Time to PSA progression* 6.6 (5.8, 9.1); 24 4.8 (2.8, 5.6); 12 Time to radiographic or clinical progression† 12.0 (8.2, 12.2); 18 9.3 (3.2, 12.2); 9 Time to PFS 6.2 (2.8, 8.8); 28 4.8 (2.8, 5.6); 12 *Per PCWG2 †Per RECIST and PCWG2
PKI Authentication System Combining with Fingerprint (2005)

Fingerprint is added into user's private key as a security parameter, and user's secret key is separated into two parts: DSS key and fingerprint by secret splitting mechanism, which makes secret key combine with user's information and further increases the security of secret key. In this authentication system, the diplex authentication technologies, fingerprint and smart card, are adopted, and user’s fingerprint need not be transmitted in the authentication process, which protects user's privacy.
Hydrogenation of Lignin in Aqueous Solutions (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of Lignin in Aqueous SolutionsElwin E. Harris, Jerome Saeman, and E. C. SherrardCite this: Ind. Eng. Chem. 1940, 32, 3, 440–441Publication Date (Print):March 1, 1940Publication History Published online1 May 2002Published inissue 1 March 1940https://pubs.acs.org/doi/10.1021/ie50363a039https://doi.org/10.1021/ie50363a039research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Complement activation, endothelial dysfunction, insulin resistance and chronic heart failure (2010)

Independent associations between sMAC, sEsel and IR were found in the CHF patients and we hypothesize that IR leading to endothelial activation results in activation of the complement system and thus damaging of the heart tissue.
Tactical Driving using Visual Routines (1998)

To meet the demands of driving in complex environments, the perception subsystem of an intelligent vehicle must be able to extract the information needed for behaviors from the input video stream. An attractive way of achieving this is to have a library of basic image processing sub-functions (visual routines), which can be composed to subserve more elaborate goal-directed programs. The crucial compositional capability allows the visual routines to span the huge space of different task goals. The visual routines presented here are developed in a unique platform. The view from a car driving in a simulated world is fed into a Datacube pipeline video processor. The integration of photo-realistic simulation and real-time image processing represents a proof of concept for a new system design which allows testing computer vision algorithms under controllable conditions, thus leading to rapid prototyping. In addition to the simulations, the routines are also tested on similar images generated...
Cluster-size dependence of proton kinetic energy from hydrogen-cluster explosion driven by laser pulse (2007)

A simplified Coulomb explosion model is presented for the analysis of the explosion dynamics of hydrogen clusters driven by an ultrashort intense laser pulse. The scaling of the proton kinetic energy with cluster size has been studied in detail based on this model. It is found that the maximum kinetic energy the protons acquire in the laser-cluster interaction rises to a peak and then decreases slightly as the cluster size increases, which can be explained very well by investigating the temporal evolution of outer ionization rate of different-size clusters. It is also indicated that there exists an optimum cluster size to maximize the proton energy for given laser parameters. Moreover, taking the cluster-size distribution as a log-normal function distribution into account, the maximum proton energy increases sharply with the cluster size and then levels off before beginning to fall slowly. The inclusion of a cluster-size distribution into the simulations considerably improves the fit with experimental data. These discussions are useful for the optimum-match determination of laser-cluster parameters to obtain the maximum proton energy in experiments.
Target y tendencias de consumo en la contemporaneidad. Perspectivas teóricas para entender nuevos sentidos (2012)

[Resumen] Actualmente sabemos que los sujetos viven constantes cambios en sus situaciones de consumo, que se contraponen al sentido de target, que es inmóvil. Lo efímero, lo provisional y la rapidez del consumo instauran nuevas modalidades de contacto entre las marcas y sus públicos. Esas nuevas perspectivas demandan rupturas con la tradición conservadora del marketing y la postulación de nuevos paradigmas teóricos, que faciliten una metodología que permita la comprensión de las semiosis que se formulan a partir de esas nuevas manifestaciones de los consumidores, mediadas por la comunicación de las marcas y que generan variadas prácticas e innovadoras situaciones de consumo. De momento, las nuevas contribuciones de la reflexión sociológica y de la antropología de consumo, en colaboración con los estudios semióticos, demuestran un potencial innovador para la construcción de una formulación teórico-metodológica que trate de comprender el tipo de vínculos de sentido entre el contexto cultural de la vida cotidiana y los signos de consumo.
Characteristics improvement of top‐gate self‐aligned amorphous indium gallium zinc oxide thin‐film transistors using a dual‐gate control (2017)

Abstract In this work, we have reported dual‐gate amorphous indium gallium zinc oxide thin‐film transistors (a‐IGZO TFTs), where a top‐gate self‐aligned TFTs has a secondary bottom gate and the TFT integration comprises only five mask steps. The electrical characteristics of a‐IGZO TFTs under different gate control are compared. With the enhanced control of the channel with two gates connected together, parameters such as on current (I ON ), sub‐threshold slope (SS −1 ), output resistance, and bias‐stress instabilities are improved in comparison with single‐gate control self‐aligned a‐IGZO TFTs. We have also investigated the applicability of the dual‐gate a‐IGZO TFTs in logic circuitry such as 19‐stage ring oscillators.
Automatic centerline extraction of coronary arteries in coronary computed tomographic angiography (2011)

Coronary computed tomographic angiography (CCTA) is a non-invasive imaging modality for the visualization of the heart and coronary arteries. To fully exploit the potential of the CCTA datasets and apply it in clinical practice, an automated coronary artery extraction approach is needed. The purpose of this paper is to present and validate a fully automatic centerline extraction algorithm for coronary arteries in CCTA images. The algorithm is based on an improved version of Frangi's vesselness filter which removes unwanted step-edge responses at the boundaries of the cardiac chambers. Building upon this new vesselness filter, the coronary artery extraction pipeline extracts the centerlines of main branches as well as side-branches automatically. This algorithm was first evaluated with a standardized evaluation framework named Rotterdam Coronary Artery Algorithm Evaluation Framework used in the MICCAI Coronary Artery Tracking challenge 2008 (CAT08). It includes 128 reference centerlines which were manually delineated. The average overlap and accuracy measures of our method were 93.7% and 0.30 mm, respectively, which ranked at the 1st and 3rd place compared to five other automatic methods presented in the CAT08. Secondly, in 50 clinical datasets, a total of 100 reference centerlines were generated from lumen contours in the transversal planes which were manually corrected by an expert from the cardiology department. In this evaluation, the average overlap and accuracy were 96.1% and 0.33 mm, respectively. The entire processing time for one dataset is less than 2 min on a standard desktop computer. In conclusion, our newly developed automatic approach can extract coronary arteries in CCTA images with excellent performances in extraction ability and accuracy.
Antimicrobial Lipids of the Skin and Oral Mucosa (2011)

This chapter contains sections titled: Skin Surface Lipids Oral Mucosal Surface Lipids Historical Perspectives on Antimicrobial Lipids Lauric Acid and Sapienic Acid Long-Chain Bases Conclusions References
Development of a Selective Laser Reaction Sintering Workstation (2018)

The purpose of this paper is to describe the design and operation&#13;\nof a Selective Laser Reaction Sintering workstation developed at The&#13;\nUniversity of Texas. The workstation allows the study of solid freeform&#13;\nfabrication of reaction sintered materials on a research scale. The&#13;\nmechanical and control systems of the workstation are detailed, and&#13;\nSelective Laser Reaction Sintering as a technique is discussed including&#13;\nexample material systems that are currently under study.
Smart Electronic Systems (2018)

Unique in focusing on both organic and inorganic materials from a system point of view, this text offers a complete overview of printed electronics integrated with classical silicon electronics. Fo ...
Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration (1999)

Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.
Role of Novel Multidrug Efflux Pump Involved in Drug Resistance in Klebsiella pneumoniae (2014)

The MFS efflux pump KpnGH involves in crucial physiological functions besides being an intrinsic resistance determinant in K. pneumoniae.
Partitioning the variance between space and time (2010)

Here we decompose the space‐time variance of near‐surface air temperature using monthly observations for the global land surface (excluding Antarctica) from 1901–2000. To do that, we developed a new method for partitioning the total space‐time variance, here called the grand variance, into separate spatial and temporal components. The temporal component is, in turn, further partitioned into the variance relating to different time periods and we use monthly data to decompose intra‐ and inter‐annual components of the variance. The results show that the spatial and temporal components of the variance of near‐surface air temperature have both, on average, decreased over time primarily because of reductions in the equator‐to‐pole (northern) temperature gradient, and because in cold regions, winter is generally warming faster than summer. We also found that in most regions, the inter‐annual variance in near‐surface air temperature has increased.
High-speed fluorescence image–enabled cell sorting (2022)

Fast and selective isolation of single cells with unique spatial and morphological traits remains a technical challenge. Here, we address this by establishing high-speed image-enabled cell sorting (ICS), which records multicolor fluorescence images and sorts cells based on measurements from image data at speeds up to 15,000 events per second. We show that ICS quantifies cell morphology and localization of labeled proteins and increases the resolution of cell cycle analyses by separating mitotic stages. We combine ICS with CRISPR-pooled screens to identify regulators of the nuclear factor κB (NF-κB) pathway, enabling the completion of genome-wide image-based screens in about 9 hours of run time. By assessing complex cellular phenotypes, ICS substantially expands the phenotypic space accessible to cell-sorting applications and pooled genetic screening.