gebhart/patrepeval huggingface dataset:
Obstructive nephropathy as a result of retroperitoneal fibrosis: a review of its pathogenesis and associations. (1997)

Retroperitoneal fibrosis is a rare disease, typically with an insidious clinical course. It is thought that this disease process is perhaps an exaggerated reaction to an inciting inflammatory event. In this study, a case of retroperitoneal fibrosis is reported, in which the patient presented with typical symptoms of retroperitoneal fibrosis, along with some atypical vasculitic symptomatology. Retroperitoneal fibrosis is a disease process with an unknown etiology, which has been observed to be associated with a number of different possible inciting factors. Two factors that have been documented in the literature as being associated with retroperitoneal fibrosis include the use of beta-blocking agents, and connective tissue disease processes such as systemic lupus erythematosus. The patient discussed was using beta-blocker medication and also had signs and symptoms suggestive of a lupus syndrome. There are no reported cases of the combined association of beta-blocker usage, lupus, and retroperitoneal fibrosis.
Radiative Annealing of Perovskite Thin Films with Alkyl Halides (2018)

The performance of the perovskite material in solar cells has garnered a fair amount of interest because it is solution processable and thus a prime target for roll-to-roll coating. The precursor materials are typically prepared in solutions and deposited using common evaporative techniques, some that can be adapted to roll-to-roll manufacturing. The deposited films then must be annealed, a process that is typically accomplished in an oven. The economics of manufacturing improve with increased web speed, which traditional deposition and ovens can handle. However, with a long anneal time the length of the ovens becomes prohibitive, thus processes that can reduce the annealing time are desired. Radiative annealing techniques are often used in the manufacture of solar cells and involve the absorption of intense light energies to induce a thermal response. Our group has been involved in the use of intense pulses of light that can effectively anneal a thin film in under a second. In this work, we report on solution engineering that enables both the deposition of the perovskite in ambient environments using roll-to-roll applicable technologies. The annealing of these thin films is accomplished using 1-5 millisecond flashes of light. The inks formulation includes an alkyl halide that interacts with the light and improving the overall morphology of the perovskite films. Scanning electron microscopy and X-ray diffraction analysis shows that the films achieve consistent morphology and crystallinity and perform well in solar cell devices. Results of several chemistries and processes will be presented.
Compression of seismic signals via recurrent neural networks: Lossy and lossless algorithms (2019)

In recent years, deep Recurrent Neural Networks (RNNs) have been successfully applied to the prediction and processing of time series data. Since there exists significant temporal correlation among samples of seismic traces, RNNs are also potentially suitable for the compression of seismic signsals. In this article, we propose two algorithms for lossy and lossless compression of seismic signals via deep RNNs. In both lossy and lossless cases, we show that the proposed compression algorithms outperform the current state of the art in two widely used seismic signal datasets. In particular, we show that seismic signals, depending on dataset, only need close to 16 bits per sample for lossless representation, rather than 32 bits per sample. Presentation Date: Tuesday, September 17, 2019 Session Start Time: 1:50 PM Presentation Start Time: 2:40 PM Location: Poster Station 9 Presentation Type: Poster
Un métier en mutation : le professorat des lycées (2013)

Entre 1840 et 1880, le professorat des lycées est soumis à deux dynamiques opposées. L’une pousse à la diversification des enseignements et à la spécialisation des enseignants. L’autre tend au contraire à revenir, sinon à l’unité de l’enseignement et au régime du maître unique qui ont longtemps caractérisé le modèle des humanités classiques, du moins à une bipolarisation des études et du professorat entre lettres et sciences, assortie d’une certaine polyvalence des professeurs à l’intérieur d...
Distributed Source Localization in Acoustic Sensor Networks Using the Coherent-to-Diffuse Power Ratio (2019)

In this paper, acoustic source localization in an acoustic sensor network (ASN) based on estimates of the coherent-to-diffuse power ratio (CDR) is investigated. It is shown that the CDR reflects the distance between an acoustic source and an observing microphone pair in real-world acoustic enclosures. As this relation is dependent on various physical parameters of the given acoustic environment which are unknown in practice, we estimate it by Gaussian process regression. Subsequently, the obtained distance estimates are used by an ASN with known relative node positions for estimating the position of the acoustic source. The algorithm is designed in a completely distributed fashion, i.e., no fusion center is needed. The computational complexity of the proposed algorithm is low and the amount of data to be shared between the sensor nodes is small and can be adjusted to the constraints imposed on the network by using a sparse Gaussian process regression method. A simulation study confirms, employing also real measurement data in a low-reverberant room, the efficacy of the proposed algorithm for a multitude of scenarios.
Automatic Deep Learning Semantic Segmentation of Ultrasound Thyroid Cineclips Using Recurrent Fully Convolutional Networks (2020)

Medical segmentation is an important but challenging task with applications in standardized report generation, remote medicine and reducing medical exam costs by assisting experts. In this paper, we exploit time sequence information using a novel spatio-temporal recurrent deep learning network to automatically segment the thyroid gland in ultrasound cineclips. We train a DeepLabv3+ based convolutional LSTM model in four stages to perform semantic segmentation by exploiting spatial context from ultrasound cineclips. The backbone DeepLabv3+ model is replicated six times and the output layers are replaced with convolutional LSTM layers in an atrous spatial pyramid pooling configuration. Our proposed model achieves mean intersection over union scores of 0.427 for cysts, 0.533 for nodules and 0.739 for thyroid. We demonstrate the potential application of convolutional LSTM models for thyroid ultrasound segmentation.
Haploid differentiation in maize kernels based on fluorescence imaging (2016)

Abstract A new fluorescence‐based method for inbred haploid differentiation in maize kernels was developed by utilizing the R1‐nj colour marker in combination with fluorescence microspectroscopy and imaging. Seven inbred lines with varying R1‐nj expression were used in this study. The fluorescence response of the diploid kernels at the embryonic dye spot was shown to simultaneously exhibit lower intensity and occur at a higher wavelength than the fluorescence of the dye‐lacking haploid embryos. Intensity and area thresholds were applied to fluorescence images to sort the haploids from mixed sample populations, and sorting efficiencies of greater than 80% were achieved in all seven inbred lines (with values greater than 90% for five lines). The potential for high‐throughput sorting when fluorescence imaging is combined with existing technologies for seed handling as well as high sorting efficiency may make fluorescence a viable and promising alternative to current sorting methods for some inbred lines.
Fundamental questions in optimizing ion-exchange chromatography of proteins using computer-aided process design (2000)

The major objectives for preparative protein chromatography are maximal loading and increased flow rate while maintaining defined resolution. Conventionally a series of chromatographic experiments are performed and the optimal conditions are selected according to the separation criteria. Computer-aided process design uses the same strategy, except a group of related experiments are generated by computer simulation. The access to concrete separation parameters for valid simulation necessitates chromatographic experiments. Optimal conditions are determined in the same manner as conducted in the conventional strategy. Beside other parameters, the distribution coefficient (K) determines the performance of a chromatographic purification under overloading conditions. In ion-exchange chromatography the distribution coefficient is strongly influenced by the protein concentration (C) and the salt concentration (I). A strategy to derive the distribution coefficient from chromatographic experiments, such as isocratic runs (pulse response), linear gradients, and frontal analysis, is described and compared to previously published strategies. In ion-exchange chromatography, the number of plates and transfer units change with the salt concentration. The distribution coefficient for salt also changes under various conditions including salt and protein concentration. The number of plates and transfer units also vary with the flow rate. Furthermore criteria such as the multicomponent situation require a more complex mathematical treatment. Several solutions have been validated to circumvent those obstacles.
Establishment and Characterization of Transplantable, Luminescence Labeled Rat Renal Cell Carcinoma Cell Lines (2010)

The new in vivo rat renal cell carcinoma model with luciferase labeled tumor cells allowed us to monitor tumor growth noninvasively and semiquantitatively by bioluminescence imaging. This model system coupled with in vitro screening permits precise evaluation of tumor behavior in intact animals and determination of the therapeutic efficacy of anticancer agents for renal cell carcinoma.
Effects of substrate misorientation and growth rate on ordering in GaInP (1994)

Epitaxial layers of GaxIn1−xP with x≊0.52 have been grown by organometallic vapor-phase epitaxy on GaAs substrates misoriented from the (001) plane in the [1̄10] direction by angles ϑm, of 0°, 3°, 6°, and 9°. For each substrate orientation growth rates rg of 1, 2, and 4 μm/h have been used. The ordering was characterized using transmission electron diffraction (TED), dark-field imaging, and photoluminescence. The (110) cross-sectional images show domains of the Cu-Pt structure separated by antiphase boundaries (APBs). The domain size and shape and the degree of order are found to be strongly affected by both the substrate misorientation and the growth rate. For example, lateral domain dimensions range from 50 Å for layers grown with rg=4 μm/h and ϑm=0° to 2500 Å for rg=1 μm/h and ϑm=9°. The APBs generally propagate from the substrate/epilayer interface to the top surface at an angle to the (001) plane that increases dramatically as the angle of misorientation increases. The angle is nearly independent of growth rate. From the superspot intensities in the TED patterns, the degree of order appears to be a maximum for ϑm≊5°. Judging from the reduction in photoluminescence peak energy caused by ordering, the maximum degree of order appears to occur at ϑm≊4°.
Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor‐mediated synaptic responses (2009)

Although an increasing number of studies have demonstrated the plasticity of NMDA receptor-mediated synaptic transmission, little is known about the molecular mechanisms that underlie this neurologically important process. In a study of NMDAR-mediated synaptic responses in hippocampal Schaffer-CA1 synapses whose AMPA receptor (AMPAR) activity is totally blocked, we uncovered differences between the trafficking mechanisms that underlie the long-term potentiation (LTP) and long-term depression (LTD) that can be induced in these cells under these conditions. The LTP-producing protocol failed to induce a change in the amplitude of NMDAR-mediated postsynaptic currents (NMDAR EPSCs) in the first 5-10 min, but induced gradual enhancement of NMDAR EPSCs thereafter that soon reached a stable magnitude. This "slow" LTP of NMDAR EPSCs (LTP(NMDA)) was blocked by inhibiting exocytosis or actin polymerization in postsynaptic cells. By contrast, LTD of NMDAR EPSCs (LTD(NMDA)) was immediately inducible, and, although it was blocked by the actin stabilizer, it was unaffected by exocytosis or endocytosis inhibitors. Furthermore, concomitant changes in the decay time of NMDAR EPSCs suggested that differential switches in NR2 subunit composition accompanied LTP(NMDA) and LTD(NMDA), and these changes were blocked by the calcium buffer BAPTA or an mGluR antagonist. Our results suggest that LTP(NMDA) and LTD(NMDA) utilize different NMDAR trafficking pathways and express different ratios of NMDAR subunits on the postsynaptic surface.
Device Pairing at the Touch of an Electrode (2018)

Device pairing is the problem of having two devices securely establish a key that can be used to secure subsequent communication. The problem arises every time two devices that do not already share a secret need to bootstrap a secure communication channel. Many solutions exist, all suited to different situations, and all with their own strengths and weaknesses.
Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges (2018)

Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD. Because these coenzymes differ in stability, bioavailability and costs, the enzyme preference for a specific coenzyme is an important issue for practical applications. Different approaches for the manipulation of coenzyme specificity have been reported, with different degrees of success. Here we present various attempts for the switching of nicotinamide coenzyme preference in oxidoreductases by protein engineering. This review covers 103 enzyme engineering studies from 82 articles and evaluates the accomplishments in terms of coenzyme specificity and catalytic efficiency compared to wild type enzymes of different classes. We analyzed different protein engineering strategies and related them with the degree of success in inverting the cofactor specificity. In general, catalytic activity is compromised when coenzyme specificity is reversed, however when switching from NAD to NADP, better results are obtained. In most of the cases, rational strategies were used, predominantly with loop exchange generating the best results. In general, the tendency of removing acidic residues and incorporating basic residues is the strategy of choice when trying to change specificity from NAD to NADP, and <i>vice versa</i>. Computational strategies and algorithms are also covered as helpful tools to guide protein engineering strategies. This mini review aims to give a general introduction to the topic, giving an overview of tools and information to work in protein engineering for the reversal of coenzyme specificity.
Analysis of Corner Kick Success in Elite Football (2015)

This study analyzes corner kicks in elite football to determine their efficacy, identify shared characteristics and associated variables, and propose a model for predicting successful outcomes. In total, 1139 kicks taken in 124 matches in the 2010 FIFA World Cup (64 matches), UEFA Euro 2012 (31 matches), and the UEFA Champions League 2010-2011 (29 matches) were studied by univariate, bivariate, and multivariate analysis. Just 2.2% of the corners ended in goal, but this goal was responsible for the team winning or drawing the match on 76% of occasions. In general, kicks are delivered through the air to the near post, with 1 or 2 intervening attackers; the attack is organized statically and the defense is a combination of zone and man-to-man. The following variables were significantly associated with corner kicks resulting in a goal: time (p=0.04), number of intervening attackers (p=0.001), and offensive organization (p=0.02). The likelihood of a shot on goal or shot could be increased with the intervention of 3 or 4 attackers, a dynamic attack, and indirect delivery of the ball to the far post. This information could be of great interest for football professionals interested in improving corner kick performance.
Dynamic properties near the nematic-smectic-A transition by ultrasonic absorption (1978)

Measurements of ultrasonic attenuation at frequencies from 0.6 to 25 MHz in magnetically aligned CBOOA are reported. On the nematic side of the A-N transition the ultrasonic absorption presents a peak in the MHz range which is more and more apparent as the frequency is decreased. This attenuation peak has been explained as being due to two contributions. One is the critical viscosity, the other reflects the behaviour of the critical heat capacity. This latter is the dominant contribution. In the smectic-A phase there is evidence of an additional relaxation mechanism which can be attributed to a Landau-Khalatnikov process. The relaxation frequency of the smectic order parameter is deduced from these measurements.
Robust, Reliable and Repairable Inkjet Print Head with Dynamic Drop Modulation Feedback for Printable Display Applications (2007)

With the advent of Liquid Crystal Display (LCD) and Flexible Display (FD) applications, a number of research and development companies have been pursuing mask-free digital inkjet printing processes to keep manufacture simple, low cost and environmentally friendly for instant, color filter pixelization, color filter black matrix application, polyimide coating, ball spacer, liquid crystal dispensing and light guide micro-lens deposition of back light unit and so forth. As a result, the key challenge is to not only control the drop placement accuracy but also provide sufficient drop volume uniformity control and real-time waveform modulation to meet the critical requirements. This paper focuses on the recent developments of a robust, reliable and repairable print head along with Addressable Waveform Trimming Circuit (AWTC) to enable drop placement accuracy and drop volume uniformity over 256 nozzles and 4-inch print width. Also reported is both the print head and the drive feedback system for the case of pixel-by-pixel dispense of red, green and blue Cholesteric Liquid Crystal (ChLC) which has been widely applied to bi-stable reflective display applications.
Ionic Liquids for Utilization of Waste Heat from Distributed Power Generation Systems (2009)

The objective of this research project was the development of ionic liquids to capture and utilize waste heat from distributed power generation systems. Ionic Liquids (ILs) are organic salts that are liquid at room temperature and they have the potential to make fundamental and far-reaching changes in the way we use energy. In particular, the focus of this project was fundamental research on the potential use of IL/CO2 mixtures in absorption-refrigeration systems. Such systems can provide cooling by utilizing waste heat from various sources, including distributed power generation. The basic objectives of the research were to design and synthesize ILs appropriate for the task, to measure and model thermophysical properties and phase behavior of ILs and IL/CO2 mixtures, and to model the performance of IL/CO2 absorption-refrigeration systems.
Preparation of Porous Pentacoordinate Organosilicon Frameworks Using Organoalkoxysilanes and Tris-catechol Linkers (2020)

Nanoporous materials with anionic pentacoordinate organosilicon frameworks were prepared using organoalkoxysilanes, tris-catechol linkers (2,3,6,7,10,11-hexahydroxytriphenylene, HHTP), and primary ...
Establishment of human malignant mesothelioma cell lines (1989)

Seventeen human malignant mesothelioma cell lines were isolated from 61 samples (46 effusions, 9 biopsies and 6 tumors obtained at autopsy) collected from patients with a confirmed malignant mesothelioma. The method used is given in detail. Cytogenetic analysis of growing cultures is the best indicator to determine whether the observed proliferation concerns malignant or normal mesothelial cells. The addition of epidermal growth factor (EGF) and hydrocortisone (HC), or EGF alone, to the culture medium increases the chances of successful isolation of a malignant mesothelioma cell line.
Vitamin B6 metabolism in Morris hepatomas. (1981)

The enzymes involved in the metabolism of vitamin B6 were measured in Morris hepatomas and livers of female Buffalo rats fed pyridoxine-sufficient and deficient diets. Pyridoxal phosphate levels in plasmas hepatomas, and livers were also determined. Nontumor-bearing animals were maintained as controls. Regardless of the B6 nutritional status, the concentration of pyridoxal phosphate was lower in the hepatomas than in the livers of the host animals. The apoenzyme levels of ornithine decarboxylase, a pyridoxal phosphate-dependent enzyme, were higher in the hepatomas from animals fed the B6-deficient diet. Liver pyridoxine kinase activity was higher in B6-sufficient animals. In contrast, tumor pyridoxine kinase activity was influenced by B6 intake and was significantly lower than that in host liver. Liver pyridoxine phosphate oxidase activity was not significantly affected by B6 intake or by the presence of tumor. In contrast, hepatomas had little or no pyridoxine phosphate oxidase activity. Pyridoxine phosphate phosphatase activity was elevated in tumors relative to livers. These data indicate that the metabolism of vitamin B6 is markedly different in the hepatomas than in host or control livers and suggest that the tumor is apparently incapable of the complete synthesis of co-enzymatically active pyridoxal phosphate from inactive precursor forms such as pyridoxine.