gebhart/patrepeval huggingface dataset:
Using Plasmonic Copper Sulfide Nanocrystals as Smart Light-Driven Sterilants (2015)

As an efficient route to control pet overpopulation and develop neutered experimental animals, male sterilization via surgical techniques, chemical injections, and antifertility vaccines has brought particular attention recently. However, these traditional ways usually induce long-term adverse reactions, immune suppression, and serious infection and pain. To overcome the above limitations, we developed a platform in the present study by using plasmonic copper sulfide nanocrystals (Cu2-xS NCs) as intelligent light-driven sterilants with ideal outcomes. Upon NIR laser irradiation, these well-prepared Cu2-xS NCs can possess NIR-induced hyperthermia and generate high levels of reactive oxygen species (ROS). Due to the cooperation of photothermal and photodynamic effects, these nanocrystals exhibited NIR-mediated toxicity toward Sertoli cells both in vitro and in vivo in a mild manner. We attribute the potential mechanism of cellular injury to the apoptosis-related death and denaturation of protein in the testicles. Furthermore, the possible metabolism route and long-term toxicity of these nanocrystals after testicular injection indicate their high biocompatibility. Taking together, our study on the NIR-induced toxicity of Cu2-xS NCs provides keen insights for the usage of plasmonic nanomaterials in biomedicine.
Epidural anaesthesia for day care surgery. (1989)

The records of 682 patients who received epidural anaesthesia for day care surgery were reviewed. The advantages and disadvantages of this form of anaesthesia is discussed. No major complications were recorded.
Microporous hollow fibres for carbon dioxide absorption: mass transfer model fitting and the supplying of carbon dioxide to microalgal cultures (1998)

A method of supplying CO2 to photosynthetic algal cultures was developed based on mass transfer measurements of CO2 through microporous hydrophobic hollow fibres for various gas and liquid flow rates. A mathematical model was derived to describe the mass transfer. The designed hollow fibre module led to overall mass transfer coefficient values ranging from 1·26 × 10−3 to 2·64 × 10−3 cm s−1. Higher efficiencies of the CO2 transmission were obtained at high liquid flow rates and low gas flow rates. The use of microporous hydrophobic hollow fibres enabled an enhancement of the carbon dioxide transfer per area of membrane surface by a factor of 10, in comparison to operation with silicone tubing. The hollow fibre module was operated in an external bypass to a 1 dm3 microalgae culture vessel. In this system the algal growth pattern was similar to that obtained with a control culture where CO2 was bubbled. However, the dissolved oxygen concentration was always lower in the vessel in which CO2 was supplied by the module. © 1998 SCI.
Rhodium and Iridium Amido Complexes Supported by Silyl Pincer Ligation: Ammonia N−H Bond Activation by a [PSiP]Ir Complex (2009)

Ir silyl pincer complexes insert into the N-H bonds of anilines and ammonia under mild conditions to form isolable [Cy-PSiP]Ir(H)(NHR) complexes that are resistant to N-H bond reductive elimination at room temperature, even in the presence of arenes, alkenes, and phosphines.
Enterprise information portals (2000)

Information is now coming centre stage in companies anxious to maintain their competitive advantage in the dot.com economy as electronic business‐to‐business exchanges rapidly emerge. The technical issues of being able to search across a wide range of different database and document types are now being solved through enterprise information portal applications (EIP), often referred to as corporate portals. These provide users with access to internal and external information resources through a customisable Web browser interface. This paper outlines the generic features of EIP applications, and categorises the different approaches being taken by EIP vendors, many of whom are adapting software developed for document management and information retrieval purposes. Emerging roles for information professionals in the deployment of EIP applications are discussed.
Brain-reactive β-amyloid antibodies in primary cns angiitis with cerebral amyloid angiopathy (2011)

Primary CNS angiitis (PCNSA) is a focal or multifocal vasculitis with predilection for small arteries that is restricted to the brain or spinal cord.1,–,3 Both diffuse lymphocytic and granulomatous inflammatory patterns are noted, which may or may not go along with focal necrosis.2,4,5 About 30% of patients with PCNSA exhibit prominent histopathologic signs of cerebral amyloid angiopathy (CAA).2,4 Compared with other patients, patients with β-amyloid (Aβ)-related angiitis (ABRA) are older and have a more acute disease onset with a high prevalence of gadolinium-enhanced MRI lesions,4 suggesting that CAA predisposes to an exacerbated inflammatory response. Whether ABRA shares the same pathomechanisms as other forms of PCNSA or belong to a different disease entity was unknown.

### Case report.

A 67-year-old man presented with psychomotor slowing, memory problems, aphasia, right-sided limb …
Utilisation d'un asservissement de fréquence pour la détermination précise des paramètres décalage et d'élargissement de la raie J: 2 → 3 d'OCS en fonction de la pression (1987)

An original microwave-frequency monitoring to be used in microwave spectrometry, in the Ka band, has been achieved. By means of this device, the monitoring of a source frequency at three particular points in a resonance line; i.e., center frequency and both symmetrical bending points, may be allowed without any static error.This experimental device enabled us to study the half-width parameters Δν L /p and shift parameter δν 0 /p of line J = 2 → 3 of OCS versus pressure. As regards Δν L /p, our values of the half-width parameter, Δν L /p = 6.25 ± 0.15 KHz∙m Torr −1 , have been checked by the conventional direct method (1 Torr = 133.3 Pa). Although more accurate, they agree with the other published values. However, δν 0 /p = 0.66 ± 0.05 KHz∙m Torr −1 is in disagreement with the two values published to date (these values being contradictory).An accurate study about the eventual causes of error ensures the reliability of this value.
Tic40 is important for reinsertion of proteins from the chloroplast stroma into the inner membrane (2008)

Chloroplast inner-membrane proteins Tic40 and Tic110 are first imported from the cytosol into the chloroplast stroma, and subsequently reinserted from the stroma into the inner membrane. However, the mechanism of reinsertion remains unclear. Here we show that Tic40 itself is involved in this reinsertion process. When precursors of either Tic40 or a Tic110 C-terminal truncate, tpTic110-Tic110N, were imported into chloroplasts isolated from a tic40-null mutant, soluble Tic40 and Tic110N intermediates accumulated in the stroma of tic40-mutant chloroplasts, due to a slower rate of reinsertion. We further show that a larger quantity of soluble Tic21 intermediates also accumulated in the stroma of tic40-mutant chloroplasts. In contrast, inner-membrane insertion of the triose-phosphate/phosphate translocator was not affected by the tic40 mutation. Our data suggest that multiple pathways exist for the insertion of chloroplast inner-membrane proteins.
Fast analysis of triterpenoids in Ganoderma lucidum spores by ultra‐performance liquid chromatography coupled with triple quadrupole mass spectrometry (2013)

A rapid and reliable method was established for simultaneous determination of main triterpenoids in Ganoderma lucidum spores using ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-TQ-MS). The established method was validated in terms of linearity, sensitivity, precision, accuracy and stability, and was successfully applied to determine the contents of 10 main triterpenoids in different batches of G. lucidum spores. The analysis results showed that moderate levels of triterpenoids were found in G. lucidum spores. In addition, a MS full scan with a daughter ion scan experiment was performed to identify the potential derivatives of triterpenoids present in G. lucidum spores. As a result, a total of 22 triterpenoids from different G. lucidum spores were unequivocally or tentatively identified via comparisons with authentic standards and literatures. This method provides both qualitative and quantitative results without the need for repetitive UPLC-MS analyses, thereby increasing efficiency and productivity, making it suitable for high-throughput applications.
Differential diagnosis of vacuolar myopathies in the NGS era (2020)

Altered autophagy accompanied by abnormal autophagic (rimmed) vacuoles detectable by light and electron microscopy is a common denominator of many familial and sporadic non-inflammatory muscle diseases. Even in the era of next generation sequencing (NGS), late-onset vacuolar myopathies remain a diagnostic challenge. We identified 32 adult vacuolar myopathy patients from 30 unrelated families, studied their clinical, histopathological and ultrastructural characteristics and performed genetic testing in index patients and relatives using Sanger sequencing and NGS including whole exome sequencing (WES). We established a molecular genetic diagnosis in 17 patients. Pathogenic mutations were found in genes typically linked to vacuolar myopathy (GNE, LDB3/ZASP, MYOT, DES and GAA), but also in genes not regularly associated with severely altered autophagy (FKRP, DYSF, CAV3, COL6A2, GYG1 and TRIM32) and in the digenic facioscapulohumeral muscular dystrophy 2. Characteristic histopathological features including distinct patterns of myofibrillar disarray and evidence of exocytosis proved to be helpful to distinguish causes of vacuolar myopathies. Biopsy validated the pathogenicity of the novel mutations p.(Phe55*) and p.(Arg216*) in GYG1 and of the p.(Leu156Pro) TRIM32 mutation combined with compound heterozygous deletion of exon 2 of TRIM32 and expanded the phenotype of Ala93Thr-caveolinopathy and of limb-girdle muscular dystrophy 2i caused by FKRP mutation. In 15 patients no causal variants were detected by Sanger sequencing and NGS panel analysis. In 12 of these cases, WES was performed, but did not yield any definite mutation or likely candidate gene. In one of these patients with a family history of muscle weakness, the vacuolar myopathy was eventually linked to chloroquine therapy. Our study illustrates the wide phenotypic and genotypic heterogeneity of vacuolar myopathies and validates the role of histopathology in assessing the pathogenicity of novel mutations detected by NGS. In a sizable portion of vacuolar myopathy cases, it remains to be shown whether the cause is hereditary or degenerative.
Targeting Seniors Through the Language of Tourism (2001)

Abstract This study focuses on senior tourism in the UK, a country that, unlike most of its European partners, has little or no social tourism providing alternative holiday settings abroad for those experiencing deprivation in the home environment. With all British overseas tourism for the elderly concentrated in the private sector, and with profit being shown a greater consideration than social well being, it thus becomes crucial to investigate just how this type of tourism is promoted. To this end, a comparative content analysis is undertaken of the recent brochures of six of the principal operators: Saga's European and the Mediterranean, Thomson's Young at Heart, Cosmos's Golden Times, JMC's Golden Circle, Airtours? Golden Years and First Choice's Leisurely Days. By highlighting their textual and pictorial imagery, it is possible to discern the main messages that are being transmitted. More specifically, attention is directed toward a number of research issues: sole targeting versus principal targeting of the over 50s, the vocabulary of motive that is employed, the portrayal of destinations and their peoples, the social control exercised over the elderly in holiday resorts and types of activity on offer. Finally, a brief examination is undertaken of the under-representation of certain groups (disabled, gays and minorities) in order to appreciate exactly who is being addressed and in what manner.
Use of Electrocardiogram to Position Right Atrial Catheters During Surgery (1997)

The ECG method is a satisfactory alternative to that of fluoroscopy for placement of long-term central venous catheters into the right atrium.
Genetic Algorithm Based on Software Diagnosis Testing (2011)

Based on genetic algorithm, the problem of software diagnosis testing is considered in this paper to reproduce the failure for the kind of systems with multi-input/output variables. Firstly, the problem prototype is abstracted, and then solutions to the prototype problems are introduced. From the aspects of coding scheme, population initialization, genetic operation, selection of fitness function, and convergence criterion, etc., how genetic algorithm can be applied in such prototype problem as software fault reproduction is thoroughly described. The experimental result shows that the injected software failure can be reproduced rapidly in the given program.
Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring (2020)

Respiratory syncytial virus (RSV) infection poses a significant risk for infants. Since the direct vaccination of infants is problematic, maternal vaccination may provide a safer, more effective approach to their protection. In the cotton rat (CR) model, we have compared the immunization of pregnant CR dams with virus-like particles assembled with the prototype mutation stabilized pre-fusion F protein, DS-Cav1, as well two alternative mutation stabilized pre-fusion proteins (UC-2 F, UC-3 F) and showed that the alternative pre-fusion F VLPs protected the offspring of immunized dams significantly better than DS-Cav1 F VLPs (Blanco, et al. J. Virol. 93: e00914). Here, we have addressed the reasons for this increased protection by characterizing the specificities of antibodies in the sera of both immunized dams and their offspring. The approach was to measure the levels of total anti-pre-F IgG serum antibodies that would block the binding of representative pre-fusion specific monoclonal antibodies to soluble pre-fusion F protein targets. Strikingly, we found that the sera in most offspring of DS-Cav1 F VLP-immunized dams had no mAb D25-blocking antibodies, although their dams had robust levels. In contrast, all offspring of UC-3 F VLP-immunized dams had robust levels of these D25-blocking antibodies. Both sets of pup sera had significant levels of mAb AM14-blocking antibodies, indicating that all pups received maternal antibodies. A lack of mAb D25-blocking antibodies in the offspring of DS-Cav1 F VLP-immunized dams may account for the lower protection of their pups from challenge compared to the offspring of UC-3 F VLP-immunized dams.
Composition and Analysis of Domestic Patented Sleeve Grouting Material (2021)

In recent years, with the urgent need of the country to vigorously promote the transformation and upgrading of the construction industry and the modernization of the construction industry, it has been proposed to vigorously develop prefabricated buildings and increase the proportion of prefabricated buildings in new buildings. The prefabricated concrete building is a concrete structure with prefabricated components in the factory and processing and connection on the construction site. Because of its fast construction speed and good overall benefits, it is widely promoted. For prefabricated buildings, the key technology is the connection of structural nodes, and most of the component connections use concrete sleeve connections. The quality of the sleeve grouting material is very important. The basic formula of the grouting material leads to different and different mechanical properties. Conditions apply. This article starts with different sleeve grouting patents, summarizes different functions and characteristics, and provides a reference for the next development of sleeve grouting.
Chromsäure-Flußsäure als spezifisches System zur Ätzgrubenentwicklung auf Silizium (1961)

Article Chromsäure-Flußsäure als spezifisches System zur Ätzgrubenentwicklung auf Silizium was published on August 1, 1961 in the journal International Journal of Materials Research (volume 52, issue 8).
Charge transport study of semiconducting polymers and their bulk heterojunction blends by capacitance measurements (2013)

Abstract We use frequency dependent capacitance measurements to probe carrier mobilities and transport parameters of six representative semiconducting polymers and some of their bulk heterojunction (BHJ) blends. With a suitable choice of a hole injection layer, well‐defined signals for hole transport characterization can be obtained for the pristine polymers [ J. Appl. Phys . 99, 013706 (2006)]. However, ill‐defined signals with negative capacitances, arising from undesirable electron leakages, are obtained for the BHJ blends. The problem of electron leakage can be circumvented by inserting an electron blocking and trapping layer under the cathode. As a result, hole transport properties of BHJ blends can be obtained. For the BHJ of poly(3‐hexylthiophene) blended with [6,6]‐phenyl‐C61‐butyric acid methyl ester (P3HT:PC 61 BM), the hole mobilities seem to be insensitive to the composition of the BHJ, indicating the P3HT component in the BHJ is well connected. On the other hand, for poly[ N ‐9“‐hepta‐decanyl‐2,7‐carbazole‐alt‐5,5‐(4′,7′‐di‐2‐thienyl‐2′,1′,3′‐benzothiadia zole)] doped with [6,6]‐phenyl‐C71‐butyric acid methyl ester (PCDTBT:PC 71 BM), a clear reduction of the hole mobility is observed as the polymer composition is reduced. Temperature dependent experiments were performed. The data are analyzed by the Gaussian Disorder Model. We found that the energetic disorder is independent of the composition of the BHJ. Organic photovoltaic performances of BHJ blends are also measured in this contribution. The correlation between device performance and energetic disorder of the BHJ will be discussed. © 2013 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013
Intracellular Salmonella enterica infection is controlled in mononuclear phagocytes that attract CXCR3+ Th1 cells in vivo and persists in those that do not (2018)

Abstract Salmonella enterica (Se) is a prototypical bacterial pathogen that persists in myeloid cells in secondary lymphoid organs and is controlled by interferon-g-producing CD4+ Th1 cells. How Th1 cells limit the infection without eliminating it is not understood. Using a PhoNdTomato S. enterica strain, we found Se bacteria inside tissue macrophages and recruited monocytes, some of which expressed inducible nitric oxide synthase (iNOS) or CXCL9 and CXCL10 ligands for CXCR3 expressed by Se-specific Th1 cells. The iNOS+ cells were clustered in red pulp regions devoid of T cells and surrounded by CXCL9/CXCL10+ cells and interspersed Th1 cells. Ablation of CD4+ T cells or blockade of CXCR3 lead to preferential loss of bacterial control in the CXCL9/CXCL10+ areas. These results suggest that Se bacteria are controlled inside myeloid cells in regions that attract CXCR3+ Th1 cells and harbored inside myeloid cells in areas that do not.
Production and characterization of antisera to synthetic thyrotropin-releasing hormone (TRH). (1982)

To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA). Six California white rabbits were each injected with 330 micrograms protein/ml of emulsified immunogen by the multisite intradermal immunization technique. Seven repeated injections were given at 30-day intervals using half of the original quantity of antigen. Antibodies binding 125I-TRH appeared in the serum of four of the six rabbits three months after the first injection. Five months later the sera of two rabbits bound 50% of the labeled TRH at 1:6000 final dilution. Using this antiserum a radioimmunoassay for TRH was developed in which as little as 10 pg/300 microliter unlabeled TRH can be detected. The linear range of detectable TRH was 10 to 10000 pg. No cross-reaction with various hypothalamic and pituitary hormones, neurotransmitters, neuropeptides, and BSA were detected in this immunoassay. Extracts from rat and frog hypothalami produced 125I-TRH-binding inhibition curves parallel to synthetic TRH. Samples from elutes of rat medio-basal hypothalami superfused in vitro were examined by using this antiserum. Serial dilution of superfusate showed a similar inhibitions curve. Stimulatory effect of K+ depolarization on TRH release from superfused hypothalami was inhibited in Ca2+-free ethylenediaminetetraacetic acid medium. Ouchterlony double diffusion test of the TRH antisera revealed that low levels of antibodies against albumin but not immunoglobulin G or ovalbumin were also produced. However, the immunoprecipitates could only be detected with undiluted serum. In conclusion, this antiserum generated one of the most sensitive TRH radioimmunoassay currently available in the literature. The anti-TRH serum produced by this method can be used to examine both content of TRH from several tissues as well as release from hypothalamic tissue in vitro and might be useful to trace brain TRH pathways by immunocytochemistry.
Action of diazomethane on methyl (Z(or E))-2-(acylamino)cinnamates. A new route to methyl (Z)-2-(acylamino)-3-methylcinnamates (1985)

Diazomethane reacts with methyl (Z(or £))-2-acetamido(or benzamido)cinnamates (1, 2) to afford regio- and&#13;\nstereospecifically (Z(or E))-4-phenyl-3-acetamido(or benzamido)-3-carbomethoxy-A1-pyrazolines (3, 4). 3Z and&#13;\n4Z undergo pyrolysis to afford stereoselectively methyl (Z)-2-acetamido(or benzamido)-3-methylcinnamates (5Z&#13;\nand 6Z). 4E undergoes pyrolysis to afford stereoselectively methyl (E)-2-phenyl-l-benzamidocyclopropane-lcarboxylate (7E).
Converting Insertion Gain to and from Headphone Coupler Responses (1997)

The equations and data presented can be used to translate insertion gain responses into responses suitable for use with equipment using headphones and, by inference, insert phones.
Manganorganische Verbindungen, V. Mitt.: Carbonsäuren des Methylcyclopentadienyl- und Cyclopentadienyl- [mangan-tricarbonyls] (1960)

Carbonsäuren des Methylcyclopentadienyl-mangan-tricarbonyls und Homologer sind durch Oxydation der entsprechenden Acetylverbindungen gut zugänglich. Einige Derivate werden beschrieben.
Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1 (2015)

Higher numbers of manic episodes in bipolar patients has, in cross-sectional studies, been associated with less grey matter volume in prefrontal brain areas. Longitudinal studies are needed to determine if manic episodes set off progressive cortical changes, or if the association is better explained by premorbid brain conditions that increase risk for mania. We followed patients with bipolar disorder type 1 for 6 years. Structural brain magnetic resonance imaging scans were performed at baseline and follow-up. We compared patients who had at least one manic episode between baseline and follow-up (Mania group, n = 13) with those who had no manic episodes (No-Mania group, n = 18). We used measures of cortical volume, thickness, and area to assess grey matter changes between baseline and follow-up. We found significantly decreased frontal cortical volume (dorsolateral prefrontal and inferior frontal cortex) in the Mania group, but no volume changes in the No-Mania group. Our results indicate that volume decrease in frontal brain regions can be attributed to the incidence of manic episodes.
Model-based fault diagnosis in technical processes (2000)

In this paper the state-of-the-art developments model-based fault diagnosis in technical processes are reviewed. Attention is focused upon both the analytical approaches that make use of the quantitative models and the knowledge-based approaches using qualitative models. Basic concepts and the advantages as well as disadvantages of different model-based fault diagnosis schemes are outlined.