gebhart/patrepeval huggingface dataset:
Study on the basic characteristics of a noncontact air conveyor for large glass sheets (2017)

Recently, the development of displays requires large, thin glass substrates, and air film conveyors equipped with porous pads have been developed to transport the substrates in a noncontact state. In this study, a contactless air film system with aligned porous pads is proposed. Experiments and analysis of its basic characteristics are conducted. First, it is confirmed that the flow rate characteristics of the porous pads can be represented by a modified Forchheimer equation with the determined permeability and inertial coefficient. Then, a theoretical model based on the Reynolds equation is established to analyze the film pressure distribution. The results indicate a parabola-like shape distributed along the radial direction in the porous area and an approximately linear curve in the periphery area. Furthermore, the experimental results indicate that the bearing force and static stiffness increase if the clearance decreased with a given flow rate. Finally, a numerical calculation performed by solving the coupling equation of elasticity and the modified Reynolds equation shows an approximate quadratic shape in the deformation, and the experimental results supported this to a certain extent.
Vulvar Paget's disease. Is immunocytochemistry helpful in assessing the surgical margins? (1990)

From January 1977 to December 1988, 19 patients with biopsy-proven Paget's disease of the vulva underwent simple or radical vulvectomy at the University of Miami/Jackson Memorial Medical Center. All vulvectomy specimens were evaluated immunocytochemically for the expression of carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and low-molecular-weight keratins 8 and 18 (LMK), both in areas containing neoplastic cells and in histologically negative surgical margins. Neoplastic Paget's cells stained positively for CEA in all cases; they were positive for EMA and LMK in 18 and 17 cases, respectively. In all eight cases with underlying in situ or invasive carcinomas, CEA, EMA and LMK were localized in the underlying tumors as well. None of the histologically proven negative margins reacted for CEA, EMA or LMK on immunocytochemistry. CEA appears to be a valuable immunocytochemical marker for extramammary Paget's disease; EMA and LMK are also expressed by the majority of such cases. None of these markers, however, is of added value in identifying Paget's cells in surgical margins if those margins appear negative on routine hematoxylin-and-eosin staining.
Electrical properties of polyacetylene doped with dihydrogen hexachloroiridate (1982)

M. Rubner, J. Georger and E. Sichel, J. Chem. Soc., Chem. Commun., 1982, 507 DOI: 10.1039/C39820000507
Evaluation of five methods to identify composite restorations in human teeth on a forensic purpose—an ex vivo comparative study (2022)

The use of tooth-colored composite resin materials in dentistry is increasing. As composite restorations appear similar to the natural tooth structure, their detection is becoming more challenging. The aim of this study was to compare five diagnostic methods for detection of dental restorations and to create reliable postmortem dental records for forensic purposes. A conventional examination method without a direct light source (CONV), with a dental loupe light (DL), Galilean loupes with a direct light source (GDL), a fluorescence-inducing device (FIT), and intraoral radiographs (RX) were compared. Dentists specializing in conservative dentistry or oral surgery and dentistry students participated. Regarding sensitivity, specificity, positive predictive value, and negative predictive value, FIT and RX showed significantly higher results than CONV, DL, and GDL. RX and FIT showed comparable results in identifying composite restorations but depending on their location. The combination of both methods may lead to even better results. In conclusion fluorescence-inducing devices show good results in identifying composite restorations and therefore should be considered as a standard tool in forensic examinations. Another advantage is their small size, low cost, and mobility. Good illumination and magnification devices are recommended to enhance performance during conventional examinations. Involving dentists specialized in conservative dentistry could contribute to dental identification.
Managing Procurement Spend Using Advanced Compliance Analytics (2011)

Often the processes for purchasing commodities and services within a business enterprise are centralized into a procurement organization. These purchases are often sourced from one or more suppliers, or vendors, based on contract terms and conditions (such as price, payment terms etc.), availability, and quality or legacy habit of purchasing service with known vendors. We have found that many organizations lack appropriate processes and disciplines to drive demand to preferred suppliers. Thus these enterprises are unable to leverage the value of the pre-negotiated contracts due to lack of process education, approval process steps or appropriate purchasing tools that could result in significant amounts of spending that would be considered not compliant (not being sourced through preferred suppliers). Depending upon the size of the organization, such transactions range from several million dollars to billions of dollars. Manually sifting or employing typical query tools to review large amounts of spend transaction data with multiple attributes to identify the level of non compliant spend and identify areas to take action is a daunting task. In this paper, we discuss a software solution for spend compliance analytics that includes measurements of cost savings due to increased compliance and identification of areas where spend tends to be non compliant. We have developed a web enabled advanced analytical solution called Compliance Analytics Tool (CAT) that embeds a two phase methodology for compliance management. In the first phase, we use advanced data mining techniques to segment a large amount of historical spend transactions to quickly identify promising areas of improvement, exploiting a multitude of purchasing attributes such as business unit, procurement category, suppliers, etc. The second phase employs portfolio optimization techniques to further focus on specific segments that provide maximum benefit based on desired compliance targets or available budget. We also discuss the solution architecture that integrates business analytics along with business intelligence tools, dashboards, and data warehousing.
Detect Kicks Prompted by Losses and Direct Measurement Well Control Method through Networked Drillstring with Along String Pressure Evaluation (2013)

Abstract Traditional well control methods rely on surface measurements to identify a kick or wellbore influx. While most well control events occur during underbalanced conditions, an influx may be prompted by major vugular losses, typically caused by a carbonate vug. During such incidents, overbalanced drilling conditions plunge and the bottomhole pressure equalizes to pore pressure in the vug. An influx at surface is never experienced, as the annulus fluid level drops. Even filling the annulus does not prevent the BHP decrease and the resulting wellbore pressure is then approximately equal to the vug pore pressure minus the hydrostatic head. Since the drilling fluid gradient exceeds the formation pressure gradient, an underbalance is created along the exposed carbonate wellbore section. Hydrocarbons may enter, flowing down towards the vug along with the displacing fluid, until the wellbore pressure is equal to the formation pressure. This paper describes efficient detection of well control events, both in underbalanced and overbalanced conditions, which is especially relevant for deepwater operations as the reaction time is significantly less than with surface BOPs. A methodology is offered to detect the annulus fluid level in conditions of unknown hydrostatic column height and fluid density through the use of discrete annular pressure acquisition along a networked drillstring. The downhole real time pressure evaluation also provides for monitoring of the gas migration to manage annular filling while losses continue to be experienced. Further, the ‘direct measurement method’ is offered for well control based on constant bottomhole pressure through downhole pressure measurements independently from surface measurements.
A new method to measure intraosseous pressures. (1986)

A new technique for measuring intraosseous pressures involves inserting a miniature transducer directly into the intraosseous space. A high-performance, high-fidelity pressure transducer is easy to assemble and insert. The transducer permits dynamic studies of intraosseous pressure during gait, and constitutes a promising tool for detecting changes in intraosseous pressure in osteoarthritis and osteonecrosis.
Lowered Electroencephalographic Spectral Edge Frequency Predicts the Presence of Cerebral White Matter Injury in Premature Infants (2003)

These data suggest that SEF-based measures are useful for defining the presence and severity of white matter injury at the bedside.
Defining Bioinformatics and Structural Bioinformatics (2003)

This chapter contains sections titled: What is Bioinformatics? Technical Challenges Within Structural Bioinformatics Integrating Structural Data with Other Data Sources References
Parallel tabu search in a heterogeneous environment (2004)

We discuss a parallel tabu search algorithm with implementation in a heterogeneous environment. Two parallelization strategies are integrated: functional decomposition and multi-search threads. In addition, domain decomposition strategy is implemented probabilistically. The performance of each strategy is observed and analyzed in terms of speeding up the search and finding better quality solutions. Experiments were conducted for the VLSI cell placement. The objective was to achieve the best possible solution in terms of interconnection length, timing performance, circuit speed, and area. The multiobjective nature of this problem is addressed using a fuzzy goal-based cost computation.
Printing in Three Dimensions with Graphene (2015)

Responsive graphene oxide sheets form non-covalent networks with optimum rheological properties for 3D printing. These networks have shear thinning behavior and sufficiently high elastic shear modulus (G') to build self-supporting 3D structures by direct write assembly. Drying and thermal reduction leads to ultra-light graphene-only structures with restored conductivity and elastomeric behavior.
Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: A case report (2015)

There are few effective treatments for recurrent glioblastoma multiforme (GBM). We present a patient with recurrent GBM who achieved a prolonged response to treatment with afatinib, an irreversible ErbB family blocker, plus temozolomide. A 58-year-old female patient was diagnosed with multifocal primary GBM. After surgical resection, first-line therapy comprised radiotherapy and temozolomide. Following disease progression after 3 temozolomide cycles, the patient entered a phase I/II clinical trial of afatinib (20-40 mg daily for 28 days) plus temozolomide (50 mg/m2 every 21/28 days). Next-generation sequencing analysis of the brain tumor specimen was performed. At the last assessment, 63 treatment cycles had been completed and the patient had survived for ~5 years since recurrence. Significant disease regression was observed after 5 cycles and was maintained during long-term follow-up. Adverse events were consistent with the known tolerability profile of afatinib and were managed by treatment interruption/dose reduction. The patient had several epidermal growth factor receptor (EGFR) aberrations, including gene amplification and EGFRvIII positivity. Three somatic mutations were identified, including an unprecedented extracellular-domain substitution (D247Y). The patient has survived ~6-fold longer than normally expected in patients with recurrent GBM. The complex EGFR genotype may underlie sustained response to afatinib plus temozolomide.
Biological therapies in the spondyloarthritides--the current state (2004)

Therapeutic options for patients suffering from the more severe spondyloarthritides (SpA) have been rather limited in the last decades. Evidence is now accumulating that anti-tumour necrosis factor (TNF) therapy is highly effective in SpA, especially in ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Based on the data recently published concerning more than 1000 patients with AS and PsA, this treatment seems to be even more effective than in rheumatoid arthritis (RA). The anti-TNFalpha agents currently available, infliximab (Remicade), etanercept (Enbrel) and adalimumab (Humira), are approved for the treatment of RA in the USA and Europe. The situation for SpA is different from RA because there is an unmet medical need, especially in AS, since no therapies with disease-modifying anti-rheumatic drugs (DMARDs) are available for severely affected patients, especially those with spinal disease. Thus, TNF blockers may even be considered a first-line treatment in a patient with active AS and PsA whose condition is not sufficiently controlled with non-steroidal anti-inflammatory drugs (NSAIDs) in the case of axial disease, and sulphasalazine or methotrexate in the case of peripheral arthritis. For infliximab, a dose of 5 mg/kg is required, and intervals of between 6 and 12 weeks are necessary to constantly suppress disease activity-also a major aim for long-term treatment. The standard dosage of etanercept is 2 x 25 mg subcutaneously per week. There are almost no studies yet on adalimumab (standard dose in RA, 20-40 mg subcutaneously every 1-2 weeks) in SpA. Infliximab and etanercept are now both approved for AS in Europe. The efficacy of etanercept was first demonstrated in PsA, and it is now approved for this indication in the USA and Europe. There is preliminary evidence that both agents also work in other SpA, such as undifferentiated SpA (uSpA). Studies should be performed to document the long-term efficacy of this treatment. There is hope that ankylosis may be preventable, but it remains to be shown whether patients benefit from long-term anti-TNF therapy and whether radiological progression and ankylosis can be stopped. Severe adverse events have remained rare. Complicated infections including tuberculosis have been reported. These can largely be prevented by appropriate screening. As it stands now, the benefits of anti-TNF therapy in AS seem to outweigh these shortcomings.
A LMI approach for designing robust FDI filters with guaranteed fault sensitivity performance (2003)

The problem of designing fault detection and isolation (FDI) filters is considered. The approach provides new techniques for designing filters that maximize fault sensitivity (effects of faults on the residual signal), while guaranteeing robustness to noise, disturbances and modeling errors. The design of the FDI filters is formulated in terms of linear matrix inequalities (LMIs) and involves the generalized structured singular value /spl mu//sub g/.
A host dicer is required for defective viral RNA production and recombinant virus vector RNA instability for a positive sense RNA virus (2008)

Defective interfering (DI) RNAs, helper virus-dependent deletion mutant RNAs derived from the parental viral genomic RNA during replication, have been described for most RNA virus taxonomic groups. We now report that DI RNA production in the chestnut blight fungus, Cryphonectria parasitica, persistently infected by virulence-attenuating positive sense RNA hypoviruses, depends on one of two host dicer genes, dcl-2. We further report that nonviral sequences that are rapidly deleted from recombinant hypovirus RNA virus vectors in wild-type and dicer gene dcl-1 deletion mutant strains are stably maintained and expressed in the Deltadcl-2 mutant strain. These results establish a requirement for dcl-2, the C. parasitica dicer gene responsible for antiviral defense and generation of virus-derived small interfering RNAs, in DI RNA production and recombinant virus vector RNA instability.
Ammonium Salts of Lithocholic Acid: Structures and Kinetics (2012)

Lithocholic acid (LCA) forms salts with n-propylamine (PPA) and sec-butylamine (sec-BUAM). The structure of (LCA–)(PPA+)·EtOH has been elucidated. LCA completely resolves sec-butylamine and the structure of (LCA–)((R)-BUAM+) has a similar packing arrangement. The kinetics of enclathration of LCA with PPA and the kinetics of decomposition of both compounds have been measured.
Texture modeling and validation using recorded high resolution sea clutter data (2002)

We consider modeling and estimating the texture in high-resolution non-Gaussian sea clutter. The cyclostationarity of sea clutter is investigated and validated by processing measured high-resolution data. The clutter is modeled as a compound Gaussian process and the texture as the superposition of real cosines with unknown frequencies, amplitudes, and phases. We propose a method for estimating the model parameters and retrieving the texture component from the intensity data in the presence of multiplicative noise (the speckle) with unknown power spectral density. The method exploits the clutter cyclostationarity and is based on a relaxation optimization approach. The ability of the proposed method to retrieve texture information is investigated by processing simulated and measured sea clutter data.
Secretion of a variant of human single-chain urokinase-type plasminogen activator without an N-glycosylation site in the methylotrophic yeast, Pichia pastoris and characterization of the secreted product (1996)

Human single-chain urokinase-type plasminogen activator without an N-glycosylation site (scu-PA-Q302) was produced in the methylotrophic yeast, Pichia pastoris using the shortened prepeptide sequence of a fungal aspartic proteinase, Mucor pusillus rennin (MPR). The level of urokinase-type plasminogen activator (u-PA) immunoreactive material in YPM medium was 0.47 mg/l; however, most of the secreted product had been processed to smaller polypeptides. The N-terminal amino acid sequence of major species was identical to that of the low molecular weight two-chain u-PA. Some approaches to minimizing the proteolysis of scu-PA-Q302 were attempted. Addition of Triton X-100, L-arginine and ammonium phosphate to the YPM medium minimized the proteolysis of scu-PA-Q302 and increased the yield of immunoreactive material to approximately 5 mg/l. Use of proteinase A- or proteinase B-deficient strains of yeast did not reduce the degradation. Co-expression of scu-PA-Q302 and urinary trypsin inhibitor resulted in partial reduction of the major species of proteolysis. Scu-PA-Q302 was purified from the culture supernatant of the improved medium by two successive chromatographies on Phenyl-Sepharose and S-Sepharose. The purified protein had a molecular weight of 47 kDa. It did not contain detectable N-linked oligosaccharides, but contained O-linked oligosaccharides attached to the light chain. N-terminal amino acid sequencing of the purified preparation showed that the shortened prepeptide sequence of MPR was correctly processed by the Pichia yeast. Scu-PA-Q302 closely resembles natural scu-PA with respect to its enzymatic activity against the chromogenic substrate S-2444 and its in vitro fibrinolytic properties.
Factors contributing to the incompatibility between simplified-step adhesives and chemically-cured or dual-cured composites. Part III. Effect of acidic resin monomers. (2003)

When the influence of adhesive permeability was excluded with the use of neat, water-free resins, deactivation of the tertiary amine utilized in the chemically-cured resin by even very low concentrations of acidic resin monomers accounts for the reported incompatibility between simplified-step dentin adhesives and chemically-cured composites. The polymerization of light-cured resin is only affected by much higher concentrations of acidic resin monomers.
When and how to evaluate mildly elevated liver enzymes in apparently healthy patients (2010)

Because 1% to 9% of people without symptoms have elevated liver enzymes, extensive evaluation of all abnormal test results would expose many patients to undue risks and expenses. On the other hand, failure to evaluate minor liver enzyme elevations could mean missing the early diagnosis of potentially treatable disorders. This review discusses likely causes of elevated aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase levels and provides algorithms for evaluating high liver enzyme values in apparently healthy patients in the primary care setting.
Multiplexing electron beam patterns using single-crystal thin films (1979)

Describes a beam-multiplexing method which alters the distribution of the electron beam for microwriting using a single-crystal film. Several patterns are addressed simultaneously using diffracted beams. The technique can be incorporated either into a scanning system to increase further the speed of writing or into projection systems to simplify the complex nature of thin-foil masks. A number of fundamental experiments have been performed using both transmission and scanning electron microscopes to demonstrate the versatility and limitations of the technique.
Properties of soluble glycoprotein VI, a potential platelet activation biomarker (2014)

Glycoprotein VI (GPVI) plays a critical role in the platelet response to collagen. Clinical studies suggest that the plasma level of soluble GPVI (sGPVI) is a highly specific and useful platelet activation marker. However, many properties of sGPVI have not been fully characterized, such as its sensitivity in detecting platelet activation and its elimination rate from the blood. In this study we established a sandwich enzyme-linked immunosorbent assay for human sGPVI, which cross-reacts to cynomolgus monkey sGPVI, and evaluated the time course of sGPVI production in a cynomolgus monkey model of lipopolysaccharide (LPS)-induced thrombocytopenia. The sGPVI levels in this model were dramatically elevated and returned to baseline by 24 hours after LPS injection, the change was more pronounced than the existing platelet activation biomarker, soluble P-selectin (sP-selectin) levels. The elimination half-life of recombinant human sGPVI was about 2.5 hours following intravenous administration to monkeys. These results suggest that plasma sGPVI closely reflects platelet activation in the bloodstream and has a short half-life. sGPVI would be a useful biomarker for disorders marked by platelet activation and for monitoring anti-platelet therapy.
ULTRASONOGRAPHIC CHANGES TO THE BICEPS TENDON RELATED TO EXERCISE (2005)

AAP Annual Meeting Abstracts: Abstracts of the Scientific Papers and Posters Presented at the Annual Meeting of the Association of Academic Physiatrists: Tucson, Arizona February 22–26, 2005: The Electrode Store Paper Presentations: Resident Award
Remote State Preparation in a Reconfigurable Quantum Local Area Network (2021)

We demonstrate remote state preparation between three spatially distributed nodes over campus fiber. Utilizing entanglement resources established through flex-grid bandwidth techniques, we nonlocally prepare desired polarization qubit states on demand, showcasing the feasibility of this quantum protocol in a deployed network.
Wideband dual‐mode planar endfire antenna with circular polarisation (2016)

A novel wideband dual‐mode planar endfire antenna with circular polarisation is presented. The antenna consists of a semicircular disk radiator and a concentrically, stub‐loaded annular sector dipole. A pair of stubs is symmetrically loaded along the annular sector dipole so that the second odd‐order dipole mode is excited and moved downwards to the fundamental mode. Thus, a wideband, planar endfire circularly polarised antenna with dual‐resonant characteristic is achieved. It is shown that the prototype has an impedance bandwidth of more than 24.8%, and a 3 dB axial ratio bandwidth of 18.8%.