gebhart/patrepeval huggingface dataset:
Selenium requirement of growing male turkeys (2008)

1. The aim of the experiment was to estimate the selenium requirement of growing male turkeys using the selenium concentrations in different organs and blood plasma and by fitting a continuous broken line to the activity of glutathione peroxidase in liver and plasma. 2. Newly hatched male BUT BIG 6 turkeys were fed either on the selenium deficient basal soybean-maize diets (selenium <0.010 mg/kg diet) adapted to the NRC (1994) and GfE (2004) recommendations for growing turkeys from 0 to 2 weeks (prestarter diet) and 3 to 5 weeks (starter diet) or the basal diets supplemented with 0.10, 0.15, 0.20, 0.25, 0.30, 0.35 or 0.40 mg selenium/kg diet as sodium selenate. Vitamin E was supplemented adequately in all diets. 3. After 5 weeks the weight in all groups (mean 2568 g) exceeded the expectations for the genotype investigated. Feed consumption and weight gain were however significantly reduced in the group receiving the selenium-deficient diet. 4. After 2 and 5 weeks selenium concentration and activity of glutathione peroxidase in the plasma and the organs examined were greatly influenced by selenium supplementation. 5. Under the conditions investigated, 0.30 mg Se/kg diet was necessary for fast-growing male turkeys to ensure maximum selenium accumulation in the organs examined and maximum glutathione peroxidase activity in plasma and liver.
ChemInform Abstract: Synthesis and Hybridization Studies of a 5‐Aminopentanoic Acid Nucleobase (APN) Dimer. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parallel, open-channel lateral flow (immuno) assay substrate based on capillary-channeled polymer films (2015)

Presented here is a novel implementation of polypropylene capillary-channeled polymer (C-CP) films, functionalized for bioaffinity separations and implemented as a platform for lateral flow (immuno) assays. The parallel ∼80 μm × 80 μm channels pass test solutions down the 30 mm film length via spontaneous wicking action, setting up the possibility for immobilizing different capture agents in the respective channels. The base-film modification process is divided into two steps: ultraviolet light treatment to improve hydrophillicity of the polypropylene substrate and the physical adsorption of a functionalized lipid tethered ligand (LTL) as a selective capture agent. The entire modification procedure is performed under ambient conditions in an aqueous solution without extreme pH conditions. In this demonstration, physical adsorption of a biotinylated-LTL onto the UV-treated PP surface selectively captures Texas Red-labeled streptavidin (SAv-TR) in the presence of enhanced green fluorescence protein (EGFP), which passes without retention in less than 5 s. In addition to the fluorescence imaging of the protein solutes, matrix assisted laser desorption/ionization-mass spectrometry (MALDI-MS) was used to confirm the formation of the LTL-SAv conjugates on the channel surface as well as to demonstrate an alternative means of probing the capture step. The present effort sets the groundwork for further development of C-CP films as a parallel, multi-analyte LFA platform; a format that to-date has not been described.
Cold Spray and Coating Research at TSRL SNL. (2015)

Abstract not provided.
Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber’s Hereditary Optic Neuropathy (2012)

Leber's hereditary optic neuropathy (LHON) is an inherited disease caused by mutations in complex I of the mitochondrial respiratory chain. The disease is characterized by loss of central vision due to retinal ganglion cell (RGC) dysfunction and optic nerve atrophy. Despite progress towards a better understanding of the disease, no therapeutic treatment is currently approved for this devastating disease. Idebenone, a short-chain benzoquinone, has shown promising evidence of efficacy in protecting vision loss and in accelerating recovery of visual acuity in patients with LHON. It was therefore of interest to study suitable LHON models in vitro and in vivo to identify anatomical correlates for this protective activity. At nanomolar concentrations, idebenone protected the rodent RGC cell line RGC-5 against complex I dysfunction in vitro. Consistent with the reported dosing and observed effects in LHON patients, we describe that in mice, idebenone penetrated into the eye at concentrations equivalent to those which protected RGC-5 cells from complex I dysfunction in vitro. Consequently, we next investigated the protective effect of idebenone in a mouse model of LHON, whereby mitochondrial complex I dysfunction was caused by exposure to rotenone. In this model, idebenone protected against the loss of retinal ganglion cells, reduction in retinal thickness and gliosis. Furthermore, consistent with this protection of retinal integrity, idebenone restored the functional loss of vision in this disease model. These results support the pharmacological activity of idebenone and indicate that idebenone holds potential as an effective treatment for vision loss in LHON patients.
Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice (2012)

Exogenous administration of recombinant human thioredoxin-1 significantly improved the survival rate and attenuated lung histological changes in the murine model of influenza pneumonia. The protective mechanism of thioredoxin-1 might be explained by its potent antioxidative and anti-inflammatory actions. Consequently, recombinant human thioredoxin-1 might be a possible pharmacological strategy for severe influenza virus infection in humans.
Creativity education by using micromachines and MEMS : The world's first micromachine Lab. for children at newly built national museum of emerging science and innovation (2002)

我々は, 青少年の創造性教育を目的に, 日本科学未来館に世界初の「マイクロマシンを自作できる工房」を創設した。この工房では, 本研究室で製作したマイクロ光造形装置を用いて3次元的なマイクロマシンを作製できる開館以来, スペースシャトルやワイングラスなど好みのデザインを短時間で製作している。今後, 青少年が自由に設計・造形するサマーキャンプや, マイクロアートコンテスト等を企画している。最先端のマイクロマシンを武器に, 物作りへの導入と, マイクロ領域の特異な物理現象を体感させる新しい創造性教育に挑戦中である。
Power-aware network swapping for wireless palmtop PCs (2004)

Virtual memory is considered to be an unlimited resource in desktop or notebook computers with high storage memory capabilities. However, in wireless mobile devices like palmtops and personal digital assistants (PDA), storage memory is limited or absent due to weight, size and power constraints. As a consequence, swapping over remote memory devices can be considered as a viable alternative. Nevertheless, power hungry wireless network interface cards (WNIC) may limit the battery lifetime and application performance if not efficiently exploited. In this work we explore performance and energy of network swapping in comparison with swapping on local micro-drives and flash memories. Our study points out that remote swapping over power-manageable WNICs can be more efficient than local swapping and that both energy and performance can be optimized through power-aware reshaping of data requests. Experimental results show that our optimization technique can save up to 60% of communication energy while improving performance.
XXXIV.—2 : 5-Iminodihydro-1 : 2 : 3-triazole. Part I. Constitution of Dimroth's 5-anilinotriazole (1923)

P. K. Dutt, J. Chem. Soc., Trans., 1923, 123, 265 DOI: 10.1039/CT9232300265
Hydrophobin Fusions for High-Level Transient Protein Expression and Purification inNicotiana benthamiana (2009)

Insufficient accumulation levels of recombinant proteins in plants and the lack of efficient purification methods for recovering these valuable proteins have hindered the development of plant biotechnology applications. Hydrophobins are small and surface-active proteins derived from filamentous fungi that can be easily purified by a surfactant-based aqueous two-phase system. In this study, the hydrophobin HFBI sequence from Trichoderma reesei was fused to green fluorescent protein (GFP) and transiently expressed in Nicotiana benthamiana plants by Agrobacterium tumefaciens infiltration. The HFBI fusion significantly enhanced the accumulation of GFP, with the concentration of the fusion protein reaching 51% of total soluble protein, while also delaying necrosis of the infiltrated leaves. Furthermore, the endoplasmic reticulum-targeted GFP-HFBI fusion induced the formation of large novel protein bodies. A simple and scalable surfactant-based aqueous two-phase system was optimized to recover the HFBI fusion proteins from leaf extracts. The single-step phase separation was able to selectively recover up to 91% of the GFP-HFBI up to concentrations of 10 mg mL(-1). HFBI fusions increased the expression levels of plant-made recombinant proteins while also providing a simple means for their subsequent purification. This hydrophobin fusion technology, when combined with the speed and posttranslational modification capabilities of plants, enhances the value of transient plant-based expression systems.
Aquifer parameter identification with kriging and optimum parameterization (1983)

A new parameter identification method is developed for a two‐dimensional, unsteady state groundwater flow model. The method is a direct approach, as it requires no iterative searching of parameters. The unknown functional coefficients (parameters) are optimally determined by a generalized matrix inversion scheme. Kriging, an unbiased minimum variance estimator, is used as a presampling filter to reconstruct the head distribution for the entire flow domain. The ill‐posedness of the inverse problem as characterized by instability and nonuniqueness is controlled by reparameterization utilizing the technique of finite elements. A set of statistics are developed to quantify explicitly the tradeoff between the system modeling error and the error associated with the parameter uncertainty. These two types of errors are shown to be a function of the parameter dimension. Residual mean square and trace of the covariance matrix of the estimated parameters serve as good indicators for the determination of the optimum parameter dimension. A set of numerical experiments are conducted to illustrate the methodology.
Influence of Clastic Dikes on Vertical Migration of Contaminants in the Vadose Zone at Hanford (2003)

This research project addressed the effect of clastic dikes on contaminant transport in the vadose zone. Clastic dikes are vertically oriented subsurface heterogeneities that are common at the Hanford Site, including in the subsurface sediments below the tank farms in the 200 West Area. Previous studies have suggested that clastic dikes may provide a fast path for transport of leaking fluid from the tanks through the vadose zone because they cut through the horizontally layered sediments at the site. The research tested the hypothesis that clastic dikes at the Hanford Site provide preferential pathways that enhance the vertical movement of moisture and contaminants through the vadose zone. Current flow and transport models of the vadose zone at the 200 Areas are based on relatively simple hydrogeologic models that assume horizontally layered sediments with no preferential vertical flow paths. To address those scientific needs, our research included field and modeling studies of the large-scale spatial distribution of clastic dikes, the hydrologic properties within dikes, and the potential effect of clastic dikes on fluid flow through the vadose zone. The data and models of the clastic dike networks produced for this project should be directly applicable to fate and transport studies conducted at the Hanford tank farms.
Brain Activity Associated with Emoticons: An fMRI Study-Effects of Facial Expressions in Personal Communications over Computer Network- (2007)

In this paper, we describe that brain activities associated with emoticons by using fMRI. In communication over a computer network, we use abstract faces such as computer graphics (CG) avatars and emoticons. These faces convey users' emotions and enrich their communications. However, the manner in which these faces influence the mental process is as yet unknown. The human brain may perceive the abstract face in an entirely different manner, depending on its level of reality. We conducted an experiment using fMRI in order to investigate the effects of emoticons. The results show that right inferior frontal gyrus, which associated with nonverbal communication, is activated by emoticons. Since the emoticons were created to reflect the real human facial expressions as accurately as possible, we believed that they would activate the right fusiform gyrus. However, this region was not found to be activated during the experiment. This finding is useful in understanding how abstract faces affect our behaviors and decision-making in communication over a computer network.
8S Globulin of Mungbean [Vigna radiata (L.) Wilczek]:  Cloning and Characterization of Its cDNA Isoforms, Expression in Escherichia coli, Purification, and Crystallization of the Major Recombinant 8S Isoform (2004)

Three isoforms of the cDNA of the major 8S globulin of mungbean, 8Salpha, 8Salpha', and 8Sbeta, were isolated, cloned, and characterized. The cDNA sequences of 8Salpha, 8Salpha', and 8Sbeta had open reading frames of 1362, 1359 or 1362, and 1359 bp, respectively, which code for 454, 453 or 454, and 453 amino acids corresponding to molecular weights of 51 973, 51 627 or 51 758, and 51 779, respectively. Homology in terms of cDNA and amino acid sequences was 91-92% between 8Salpha and 8Salpha', 87% between 8Salpha and 8Sbeta, and 86-88% between 8Salpha' and 8Sbeta. The signal peptide was found to be 1-25, 1-24 or 25, and 1-23 for 8Salpha, 8Salpha', and 8Sbeta, respectively, using the signalP website (Nielsen, H.; Engelbrecht, J.; Brunak, S.; von Heijne, G. Protein Eng. 1997, 10, 1-6). The propeptide was determined to be IVHREN. A single site for glycosylation (N-X-S/T) was observed about 90 amino acids from the C terminus. Homology between mungbean 8S isoforms and other 7-8S proteins ranged from 45 to 68% within members of the legume family and 29 to 34% for crops of different species. The major isoform 8Salpha was expressed in Escherichia coli and purified by successive ammonium sulfate fractionation, hydrophobic interaction, and Mono Q column chromatography. The recombinant 8Salpha, but not the native form, was successfully crystallized producing rhombohedral crystals.
Iterative techniques to integrate different optical functions in a diffractive phase element (1991)

Diffractive optics allows the incorporation of several optical functions, e.g., wave shaping and focusing, in one element. A method suitable to calculate a diffractive phase element with this feature is described. Coding and quantization effects are analyzed. As an example an array generator with integrated focal power is designed.
Werkstoffdatenblätter (2019)

No AccessZeitstandverhalten von metallischen WerkstoffenMar 2019WerkstoffdatenblätterUlrich BrillUlrich Brillhttps://doi.org/10.3139/9783446459854.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2019Pages: 23-24Print ISBN: 978-3-446-45531-3eISBN: 978-3-446-45985-4 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems (2010)

We have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have been shown in plant and invertebrate systems to play a key role in host responses to viral infection. Although homologs of the key RNAi effector pathways are present in mammalian cells, and can launch an RNAi-mediated degradation of experimentally targeted mRNAs, any role for such responses in mammalian host-virus interactions remains to be characterized. Six different viruses were examined in 41 experimentally susceptible and resistant host systems. We identified virus-derived small RNAs (vsRNAs) from all six viruses, with total abundance varying from "vanishingly rare" (less than 0.1% of cellular small RNA) to highly abundant (comparable to abundant micro-RNAs "miRNAs"). In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host miRNA profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We also found evidence for populations of vsRNAs that exist as duplexed siRNAs with zero to three nucleotide 3' overhangs. Using populations of cells carrying a Hepatitis C replicon, we observed strand-selective loading of siRNAs onto Argonaute complexes. These experiments define vsRNAs as one possible component of the interplay between animal viruses and their hosts.
Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. (2004)

A new HPLC-method for the separation of medium polar and nonpolar compounds in preparations of Valeriana officinalis was established for stability control. Powdered valerian root and a commercial ethanolic valerian extract were investigated for apparent differences in stability behaviour. Storage conditions were chosen according to the ICH-guidelines. Changes in composition of valerenic acids and lignans were observed depending on storage conditions and packaging materials. Hydroxyvalerenic acid, pinoresinol and hydroxypinoresinol were identified as degradation products in Valerian root, especially during accelerated testing. Ethanolic extracts appeared not to be as sensitive for chemical degradation under climatic influences compared to the crude plant material, and showed no increase in the amounts of lignan-aglyka. In comparison, extracts showed high sensitivity on changes of physical properties like loss on drying and viscosity.
Containment and Support: Core and Complexity in Spatial Language Learning (2016)

Containment and support have traditionally been assumed to represent universal conceptual foundations for spatial terms. This assumption can be challenged, however: English in and on are applied across a surprisingly broad range of exemplars, and comparable terms in other languages show significant variation in their application. We propose that the broad domains of both containment and support have internal structure that reflects different subtypes, that this structure is reflected in basic spatial term usage across languages, and that it constrains children's spatial term learning. Using a newly developed battery, we asked how adults and 4-year-old children speaking English or Greek distribute basic spatial terms across subtypes of containment and support. We found that containment showed similar distributions of basic terms across subtypes among all groups while support showed such similarity only among adults, with striking differences between children learning English versus Greek. We conclude that the two domains differ considerably in the learning problems they present, and that learning in and on is remarkably complex. Together, our results point to the need for a more nuanced view of spatial term learning.
Caries formation around restorative composite and glass ionomer cement (2014)

Made available in DSpace on 2016-01-28T16:55:17Z (GMT). No. of bitstreams: 0\n Previous issue date: 2014. Added 1 bitstream(s) on 2016-01-28T17:02:06Z : No. of bitstreams: 1\nISSN1677-6704-2014-35-02-46-50.pdf: 621693 bytes, checksum: 200f3fa7bbad3ab8a9ac87c5930f9540 (MD5)
Rubidium Ultra-Stable Oscillators at Titan: The Huygens Doppler Wind Experiment (1997)

The Doppler Wind Experiment (DWE) is one of six investigations to be performed during the Titan atmospheric descent of the ESA Huygens Probe. The primary scientific objective is to measure the direction and strength of Titan's zonal winds with an accuracy better than 1 m/s. The Probe's wind-induced horizontal motion will be derived from the residual Doppler shift of its S-band radio link to the Cassini Orbiter, corrected for all known orbit and propagation effects, from the beginning of the mission (altitude: approx. 160 km) down to impact on the surface. The DWE Instrumentation consists of Rb-based Ultra-Stable Oscillators used to: (1) generate the transmitted signal from the Probe and (2) extract the frequency of the received signal on the Orbiter. The capabilities of these USOs under the rugged experimental conditions on Titan and some results from the DWE pre-launch test program are described.
Experimental study of microemulsion characterization and optimization in enhanced oil recovery : a design approach for reservoirs with high salinity and hardness (2017)

The objective of this research was to develop a systematic laboratory approach, and design a high performance chemical flood for a problematic reservoir with formation brine having high salinity and hardness. Aqueous and microemulsion phase behavior tests have previously been shown to be a rapid, inexpensive and highly effective means to select the best chemicals and minimize the need for relatively expensive core flood tests. Phase behavior tests were therefore done with various combinations of surfactants, co-solvents and alkali for several crude oils and reservoir conditions, including the problematic reservoir of interest for design. Extensive phase behavior testing identified performance trends of chemicals at different concentrations, which could be interpolated for optimization. The trends were ultimately used to develop an approach to design potential chemical flood formulations for the problematic reservoir of interest. Using this approach, several formulations were designed showing good performance in phase behavior testing. One of the formulations was then validated in a core flood experiment to give nearly 100% oil recovery with very low surfactant adsorption. The chemical flood design used a salinity gradient that was robust enough with withstand the sharp salinity contrast of the formation brine and surfactant slug at the displacement front. Salinity analysis of core flood effluent showed how Type III microemulsion conditions were targeted to most effectively mobilize residual oil.
Scenario-based Evaluation of Prediction Models for Automated Vehicles (2022)

To operate safely, an automated vehicle (AV) must anticipate how the environment around it will evolve. For that purpose, it is important to know which prediction models are most appropriate for every situation. Currently, assessment of prediction models is often performed over a set of trajectories without distinction of the type of movement they capture, resulting in the inability to determine the suitability of each model for different situations. In this work we illustrate how standardized evaluation methods result in wrong conclusions regarding a model's predictive capabilities, preventing a clear assessment of prediction models and potentially leading to dangerous on-road situations. We argue that following evaluation practices in safety assessment for AVs, assessment of prediction models should be performed in a scenario-based fashion. To encourage scenario-based assessment of prediction models and illustrate the dangers of improper assessment, we categorize trajectories of the Waymo Open Motion dataset according to the type of movement they capture. Next, three different models are thoroughly evaluated for different trajectory types and prediction horizons. Results show that common evaluation methods are insufficient and the assessment should be performed depending on the application in which the model will operate.