gebhart/patrepeval huggingface dataset:
Transurethral Microwave Hyperthermia for Benign Prostatic Hyperplasia: The Leuven Clinical Experience (1993)

Local microwave hyperthermia, delivered transurethrally or transrectally, is a new treatment modality for benign prostatic hyperplasia. We started transurethral application, delivering 915-MHz microwaves at the prostatic urethra using a helical microwave antenna incorporated in a Foley catheter. This hyperthermia was given without a urethral surface cooling system. Thermophysical testing of the applicator proved therapeutic efficacy in vitro and in vivo. Pathologic studies demonstrated hyperthermia-induced lesions in the periurethral prostatic tissues and permitted us to hypothesize a working mechanism of transurethral hyperthermia. Clinical Phase I and II studies showed clinical efficacy in patients with urinary retention or prostatism secondary to benign hyperplasia, especially in bilobar or trilobar prostatic configurations. While awaiting results of further pathologic and thermophysical experimental work and ongoing Phase II and III studies, we consider transurethral hyperthermia an investigational but promising conservative treatment modality for benign prostatic hyperplasia.
Supplementary Table S2 from A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy (2023)

&lt;p&gt;Table S2: Protein phosphorylation events distinct in αEPHA2-Cond and cIgG-Tr cells.&lt;/p&gt;
Pulmonary embolus in pregnant patients: survey of ventilation-perfusion imaging policies and practices. (1998)

Most respondents perform V-P imaging in pregnant patients suspected of having pulmonary embolus, with considerable variability in their policies and practices.
Security for Network Attached Storage Devices (CMU-CS-97-185) (2018)

This paper presents a novel cryptographic capability system addressing the security and performance needs of network attached storage systems in which file management functions occur at a different location than the file storage device. In our NASD system file managers issue capabilities to client machines, which can then directly access files stored on the network attached storage device without intervention by a file server. These capabilities may be reused by the client, so that interaction with the file manager is kept to a minimum. Our system emphasizes performance and scalability while separating the roles of decision maker (issuing capabilities) and verifier (validating a capability). We have demonstrated our system with adaptations of both the NFS and AFS distributed file systems using a prototype NASD implementation.
Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4 (2019)

Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a heterodimer (UN), and functions as a cofactor for the Cdc48 ATPase. Here, we report the crystal structures of yeast Npl4 in complex with Lys48-linked diubiquitin and with the Npl4-binding motif of Ufd1. The distal and proximal ubiquitin moieties of Lys48-linked diubiquitin primarily interact with the C-terminal helix and N-terminal loop of the Npl4 C-terminal domain (CTD), respectively. Mutational analysis suggests that the CTD contributes to linkage selectivity and initial binding of ubiquitin chains. Ufd1 occupies a hydrophobic groove of the Mpr1/Pad1 N-terminal (MPN) domain of Npl4, which corresponds to the catalytic groove of the MPN domain of JAB1/MPN/Mov34 metalloenzyme (JAMM)-family deubiquitylating enzyme. This study provides important structural insights into the polyubiquitin chain recognition by the Cdc48-UN complex and its assembly.
Ka-band fundamental-mode peniotron with high device efficiency (2003)

Summary form only given. The peniotron interaction has been proven capable of yielding extremely high electronic conversion efficiency. Efficiency has been demonstrated as high as 75% (Ishihara et al, 1999) and greater than 80% has been predicted. This inherently high efficiency is due to the nature of the interaction. In the peniotron, the electrons move forward in phase by 360/spl deg/ with each cyclotron orbit. Therefore, the electrons see the transverse component of the resonant wave as a "DC" electric field, experience E/spl times/B drift, and lose their transverse energy to the wave. This interaction is optimal for an axis encircling electron beam and for a well designed device (with a high quality beam), the transfer of transverse energy can approach 100% for all electrons in the beam. While high conversion efficiency has been demonstrated, practical application of the peniotron requires that high power be efficiently extracted from the device while immunity from competing gyrotron modes is maintained. The objective of the UCD harmonic peniotron is to achieve high overall device efficiency while insuring stability through the use of a fundamental mode interaction with the second cyclotron harmonic of an axis-encircling beam generated by a Northrop Grumman Cusp gun.
Estimation of the Yield Coefficient of Pseudomonas sp. Strain DP-4 with a Low Substrate (2,4-Dichlorophenol [DCP]) Concentration in a Mineral Medium from Which Uncharacterized Organic Compounds Were Eliminated by a Non-DCP-Degrading Organism (2000)

The yield coefficient (YC) of Pseudomonas sp. strain DP-4, a 2, 4-dichlorophenol (DCP)-degrading organism, was estimated from the number of CFU produced at the expense of 1 unit amount of DCP at low concentrations. At a low concentration of DCP, the YC can be overestimated in pure culture, because DP-4 assimilated not only DCP but also uncharacterized organic compounds contaminating a mineral salt medium. The concentration of these uncharacterized organic compounds was nutritionally equivalent to 0.7 microg of DCP-C ml(-1). A mixed culture with non-DCP-degrading organisms resulted in elimination of ca. 99.9% of the uncharacterized organic compounds, and then DP-4 assimilated only DCP as a substrate. In a mixed culture, DP-4 degraded an initial concentration of 0.1 to 10 microg of C ml of DCP(-1) and the number of CFU of DP-4 increased. In the mixed culture, DCP at an initial concentration of 0.07 microg of C ml(-1) was degraded. However, the number of CFU of DP-4 did not increase. DCP at an extremely low initial concentration of 0.01 microg of C ml(-1) was not degraded in mixed culture even by a high density, 10(5) CFU ml(-1), of DP-4. When glucose was added to this mixed culture to a final concentration of 1 microg of C ml(-1), the initial concentration of 0.01 microg of C ml of DCP(-1) was degraded. These results suggested that DP-4 required cosubstrates to degrade DCP at an extremely low initial concentration of 0.01 microg of C ml(-1). The YCs of DP-4 at the expense of DCP alone decreased discontinuously with the decrease of the initial concentration of DCP, i.e., 1.5, 0.19, or 0 CFU per pg of DCP-C when 0.7 to 10, 0.1 to 0.5, or 0.07 microg of C ml of DCP(-1) was degraded, respectively. In this study, we developed a new method to eliminate uncharacterized organic compounds, and we estimated the YC of DP-4 at the expense of DCP as a sole source of carbon.
Action-Potential-Independent GABAergic Tone Mediated by Nicotinic Stimulation of Immature Striatal Miniature Synaptic Transmission (2007)

Stimulation of presynaptic nicotinic acetylcholine receptors (nAChRs) increases the frequency of miniature excitatory synaptic activity (mEPSCs) to a point where they can promote cell firing in hippocampal CA3 neurons. We have evaluated whether nicotine regulation of miniature synaptic activity can be extended to inhibitory transmission onto striatal medium spiny projection neurons (MSNs) in acute brain slices. Bath application of micromolar nicotine typically induced 12-fold increases in the frequency of miniature inhibitory synaptic currents (mIPSCs). Little effect was observed on the amplitude of mIPSCs or mEPSCs under these conditions. Nicotine stimulation of mIPSCs was dependent on entry of extracellular calcium because removal of calcium from perfusate was able to block its action. To assess the potential physiological significance of the nicotine-stimulated increase in mIPSC frequency, we also examined the nicotine effect on evoked IPSCs (eIPSCs). eIPSCs were markedly attenuated by nicotine. This effect could be attributed to two potential mechanisms: transmitter depletion due to extremely high mIPSC rates and/or a reduction in presynaptic excitability associated with nicotinic depolarization. Treatment with low concentrations of K(+) was able to in part mimic nicotine's stimulatory effect on mIPSCs and inhibitory effect on eIPSCs. Current-clamp recordings confirmed a direct depolarizing action of nicotine that could dampen eIPSC activity leading to a switch to striatal inhibitory synaptic transmission mediated by tonic mIPSCs.
Effect of Oxygen Supply onl-Lysine,l-Threonine andl-Isoleucine Fermentations (1979)

Journal Article Effect of Oxygen Supply on l-Lysine, l-Threonine and l-Isoleucine Fermentations Get access Kunihiko Akashi, Kunihiko Akashi Central Research Laboratories of Ajinomoto Co., Ltd., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshiro Shibai, Hiroshiro Shibai Central Research Laboratories of Ajinomoto Co., Ltd., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshio Hirose Yoshio Hirose Central Research Laboratories of Ajinomoto Co., Ltd., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 43, Issue 10, 1 October 1979, Pages 2087–2092, https://doi.org/10.1080/00021369.1979.10863778 Published: 01 October 1979 Article history Received: 21 February 1979 Published: 01 October 1979
Equilibrium between Cerium and Sulphur in Liquid Iron (1975)

Cerium-sulfur equilibrium was studiel by melting Fe-S, Fe-C-S, or Fe-Mn-S alloys in high frequency furnace with subsequent addition of cerium under deoxidized argon. The possible reaction between Ce and crucible material was prevented by lining and sintering of CeS powder (3 mm thickness) on alumina crucible in which the melts were contained. Care was also taken to keep total oxygen in the melt to be less than 10 ppm by adding 0.1% aluminum prior to the addition of Ce.The results obtained are:1) Precipitates identified as CeS by EPMA indicate that the equilibrium is expressed by CeS (S) =Ce+S.2) Equilibrium constant, K=acϑ·aS (a: Henrian activity), and interaction coefficients involved are determined to belog K=-20600/T+6.39e (Ce) S=-13.6 (1823°K), -9.1 (1873°K), -7.5 (1923°K)for T=1823-1923°K and [%Ce] +4.37 [%S] ≤0.16, ande (C) Ce=-0.077, e (Mn) Ce=0.13at 1873°K.3) Standard free energy of solution, ΔG0, for Ce (1) =Ce is derived asΔGO=-4900-16.0TDisagreement among the data previously reported for the solubility product, K′ = [%Ce] [%S], is interpretable by taking the given dependence of K′ on [%Ce] and [%S] into account.
Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages (2002)

Lipid-loaded macrophage "foam cells" accumulate in the subendothelial space during the development of fatty streaks and atherosclerotic lesions. To better understand the consequences of such lipid loading, murine peritoneal macrophages were isolated and incubated with ligands for two nuclear receptors, liver X receptor (LXR) and retinoic acid receptor (RXR). Analysis of the expressed mRNAs using microarray technology led to the identification of four highly induced genes that encode apolipoproteins E, C-I, C-IV, and C-II. Northern blot analysis confirmed that the mRNA levels of these four genes were induced 2-14-fold in response to natural or synthetic ligands for LXR and/or RXR. The induction of all four mRNAs was greatly attenuated in peritoneal macrophages derived from LXRalpha/beta null mice. The two LXR response elements located within the multienhancers ME.1 and ME.2 were shown to be essential for the induction of apoC-II promoter-reporter genes by ligands for LXR and/or RXR. Finally, immunohistochemical studies demonstrate that apoC-II protein co-localizes with macrophages within murine arterial lesions. Taken together, these studies demonstrate that activated LXR induces the expression of the apoE/C-I/C-IV/C-II gene cluster in both human and murine macrophages. These results suggest an alternative mechanism by which lipids are removed from macrophage foam cells.
Supplementary Figures 1-4 from <sup>18</sup>F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers (2023)

Supplementary Figures 1-4 from &lt;sup&gt;18&lt;/sup&gt;F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
Analysis of a two-fluid EHD power generator including effects of compressibility (1980)

A detailed analysis and method of calculation is presented for determining the complete thermodynamic cycle of either a one-fluid or a two-fluid electrohydrodynamic (EHD) power generator. The analysis takes fully into account the compressibility of the media. Parameters are included which express the thermodynamic losses in the various components of the overall system. The severe restriction on output created by the electrical breakdown limit of the medium is clearly shown. The method for computing the net-electrical work output per unit mass of primary fluid and the net overall thermal efficiency of the system is carefully developed. The calculation procedure is illustrated by a completely worked out numerical example. The techniques presented here may be used to determine the performance possibilities and limitations of various one-fluid and two-fluid EHD power generators. (Author)
PURIFICATION AND PARTIAL CHARACTERIZATION OF FILAMENTOUS HAEMAGGLUTININ FROM BORDETELLAPERTUSSIS USING MONOCLONAL ANTIBODIES (2009)

Two monoclonal antibodies against filamentous haemagglutinin (F-HA) from Bordetella have been produced. In immunoblotting of a SDS-polyacrylamide gel electrophoresis (SDS-PAGE) of high ionic strength extracts of Bordetella pertussis, the two monoclonal antibodies both stained several high molecular weight bands. The two monoclonal antibodies were used for immuno-affinity column one-step purification of F-HA from high-ionic-strength extracts of Bordetella pertussis. In gradient SDS-PAGE, the eluted F-HA is present as a major double band with a molecular weight of approximately 240,000 daltons and several minor bands with molecular weights down to 90,000 daltons. The monoclonal antibodies were used in a monoclonal antibody catching enzyme linked immunosorbent assay (ELISA) for sensitive and specific detection of F-HA. This ELISA system proved valuable in optimizing the elution conditions for the monoclonal affinity columns.
Benzimidazole Derivatives: Selective Fluorescent Chemosensors for the Picogram Detection of Picric Acid (2014)

1,3,5-Tri(1H-benzo[d]imidazol-2-yl)benzene derivatives, as a new kind of fluorescent chemosensor for the detection of nitroaromatic explosives, are designed and synthesized by simple N-hydrocarbylation. Among 16 obtained compounds, compound 4g has the best capability for detection of picric acid (PA), having good selectivity and high sensitivity. The detection of PA with 4g solution-coated paper strips at the picogram level is developed. A simple, portable, and low-cost method is provided for detecting PA in solution and contact mode.
Strength Envelopes of Florida Carbonate Rocks near Ground Surface (2019)

Florida carbonate rocks are typically weak, with a median unconfined compressive strength value of approximately 3 MPa. Due to the infeasibility of attaching strain gauges to their vuggy and shelly surfaces, an innovative volume change device was added to a Hoek cell triaxial system, enabling the measurement of volumetric responses during triaxial tests. In this study, 223 triaxial tests on five different Florida rock formations were performed, with confining pressures ranging from 0.35 to 20.7 MPa. The tests indicate that (1) only a small percentage of Florida carbonate rocks exhibit brittle rupture; and (2) most Florida carbonate rocks exhibit ductile stress-strain behavior, even at the lowest confining pressure. A ductile response is typically associated with contractive volumetric behavior due to the rock’s porous structure. The study established a ductile threshold σd/σ3 ratio, which was found to not be a constant, but to vary with confining pressure. It was confirmed through the triaxial test results that (1) the Hoek-Brown criterion works well for the dense specimens, which are not commonly encountered in Florida; and (2) for the typical porous Florida rocks, the stress-strain response is ductile and the strength envelopes in Lambe’s p-q diagram have a linear increasing (constant slope) zone followed by a decreasing slope zone, which is a function of the Florida formations as well as the specimens’ bulk dry unit weights.
Time Division Multiplex Systems (1941)

THE idea of transmitting and receiving independent signals over a common line by means of synchronized switches at the terminals is quite old and has been used in multiplex telegraphy for many years. In general if N signal channels are to be provided over one line, the switching cycle includes N equal time intervals, one of which is allotted to each channel. Each channel is connected to the line throughout a part of its particular time interval and is disconnected throughout the remainder of the cycle. Absence of interference between the channels depends upon the fact that the channels are connected to the line throughout mutually exclusive time intervals. It is thus possible to avoid the use of channel band filters such as are necessary in carrier systems employing frequency as the basis of separation.
Practical utility of thermodilution versus doppler ultrasound to measure hemodialysis blood access flow. (2013)

TD represents a good indirect method of Qa measurement. In the subgroup of patients with radiocephalic AVFs, Qa measurements in the radial and ulnar artery are more accurate. Therefore, in this situation the TD method obtained an excellent correlation in comparison to brachial artery.
Describing patients' normal tissue reactions: Concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity (1998)

Clinical radiotherapeutic doses are limited by the tolerance of normal tissues. Patients given a standard treatment exhibit a range of normal tissue reactions, and a better understanding of this individual variation might allow for individualisation of radiotherapeutic prescriptions, with consequent improvement in the therapeutic ratio. At present, there is no simple way to describe normal tissue reactions, which hampers communication between clinic and laboratory and between groups from different centres. There is also no method for comparing the severity of reactions in different normal tissues. This arises largely because there is no definition of a "normal" reaction, an "extreme" reaction or the particular term "over-reactor" (OR). This report proposes definitions for these terms, as well as a simple terminology for describing normal tissue reactions in patients having radiotherapy. The "normal" range represents the individual variation in normal tissue reactions amongst large numbers of patients treated in the same way which is within clinically acceptable limits. The term "OR" is applied to an individual whose reaction is more severe than the normal range but also implies that this forced a major change in the radiotherapeutic prescription or that the reactions were very severe or fatal. A "severe OR" would develop serious problems with a typical radical dose, while an "extreme OR" would have such difficulties at a much lower dose. To describe the normal range, a numerical scale is suggested, from 1 to 5, resistant to sensitive. The term "highly radiosensitive" (HR) is suggested for category 5. An "informal" relative scale, as suggested here, is quick and simple. It should allow comparison between different hospitals, compensate for differences in radiotherapeutic dose and technique and allow comparison of reactions between different anatomical sites. It should be adequate for discriminating patients at the extremes of the normal range from those at the centre. It is hoped that the definitions and terminology proposed here will aid communication in the field of predictive testing of normal tissue radiosensitivity.
Fftnet: A Real-Time Speaker-Dependent Neural Vocoder (2018)

We introduce FFTNet, a deep learning approach synthesizing audio waveforms. Our approach builds on the recent WaveNet project, which showed that it was possible to synthesize a natural sounding audio waveform directly from a deep convolutional neural network. FFTNet offers two improvements over WaveNet. First it is substantially faster, allowing for real-time synthesis of audio waveforms. Second, when used as a vocoder, the resulting speech sounds more natural, as measured via a “mean opinion score” test.
Beamspace Root-MUSIC for minimum redundancy linear arrays (1993)

Beamspace Root-MUSIC, a computationally efficient beamspace implementation of Root-MUSIC developed recently for use in conjunction with a uniformly spaced linear array (ULA), is discussed. Computationally efficient methods for using beamspace Root-MUSIC in conjunction with a minimum redundancy linear array (MRLA) for both the narrowband and wideband cases are developed. The MRLA is attractive in that it offers enhanced detection performance and enhanced resolution capability relative to a ULA having the same number of elements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Angiotensin‐converting enzyme inhibitors in the therapy of renal diseases (2004)

Renal diseases, especially chronic renal failure (CRF), are common in canine and feline medicine. The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in these conditions in the development of renal lesions and the progression of kidney dysfunction. Angiotensin-converting enzyme inhibitors (ACEI) are currently considered as the most efficient agents in therapeutic strategies. The benefit of an ACEI treatment can be explained by at least three mechanisms: ACEI limit systemic and glomerular capillary hypertension, have an antiproteinuric effect, and retard the development of glomerulosclerosis and tubulointerstitial lesions. These effects have been studied in dogs and cats, and there is now some evidence to support the recommendation of ACEI therapy in dogs and cats with CRF. Nevertheless the prescription of ACEI in such patients should take into account the potential influence of renal impairment on ACEI disposition, and adverse effects on the renal function itself (especially hypotension and acute reductions in glomerular filtration rate). The risk of drug interaction with diuretics, nonsteroidal anti-inflammatory drugs and anesthetics, should not be overestimated. Furthermore, hypotension may occur in patients on a low sodium diet.
1H and 13C NMR spectral assignments of an amino acid-coumarin hybrid (2013)

Synthesis and detailed spectral analysis of a new 4-substituted coumarin-amino acid derivate are presented in this paper. A new glycine derivate of (3-nitro-2-oxo-2H-chromen-4-yl)amino]acetate was prepared by condensation of 4-chloro-3-nitrocoumarin and ethyl glycinate hydrochloride. The complete assignment of 1H and 13C NMR chemical shifts of the synthesized compound was carried out by the aid of a combination of 1D (1H and 13C NMR) and 2D (1H-1H-COSY, NOESY, HSQC and HMBC) NMR experiments.