gebhart/patrepeval huggingface dataset:
Highly efficient white-light-emitting diodes fabricated with short-wavelength yellow oxynitride phosphors (2006)

We have already reported orangish yellow Ca–α-SiAlON:Eu2+ phosphors, and applied them to fabricate warm white light-emitting diodes (LEDs). In this letter, we report on greenish yellow Li–α-SiAlON:Eu2+ phosphors, and use them to create daylight when coupled to an InGaN blue LED chip (460nm). The newly discovered Li–α-SiAlON:Eu2+ phosphors emit at shorter wavelengths of 573–577nm under the 460nm excitation, and exhibit a smaller Stokes shift than Ca–α-SiAlON:Eu2+ does. By using this short-wavelength yellow oxynitride phosphor, bright daylight emissions from white LEDs can be generated. Thus, highly efficient white LEDs with tunable white light can be fabricated with α-SiAlON:Eu2+ phosphors, enabling them for a wider range of applications.
MAGNETIC RESONANCE IMAGING SUSCEPTIBILITY ARTIFACTS DUE TO METALLIC FOREIGN BODIES (2011)

Susceptibility artifacts due to metallic foreign bodies may interfere with interpretation of magnetic resonance (MR) imaging studies. Additionally, migration of metallic objects may pose a risk to patients undergoing MR imaging. Our purpose was to investigate prevalence, underlying cause, and diagnostic implications of susceptibility artifacts in small animal MR imaging and report associated adverse effects. MR imaging studies performed in dogs and cats between April 2008 and March 2010 were evaluated retrospectively for the presence of susceptibility artifacts associated with metallic foreign bodies. Studies were performed using a 1.0 T scanner. Severity of artifacts was graded as 0 (no interference with area of interest), 1 (extension of artifact to area of interest without impairment of diagnostic quality), 2 (impairment of diagnostic quality but diagnosis still possible), or 3 (severe involvement of area of interest resulting in nondiagnostic study). Medical records were evaluated retrospectively to identify adverse effects. Susceptibility artifacts were present in 99/754 (13.1%) of MR imaging studies and were most common in examinations of the brachial plexus, thorax, and cervical spine. Artifacts were caused by identification microchips, ballistic fragments, skin staples/suture material, hemoclips, an ameroid constrictor, and surgical hardware. Three studies were nondiagnostic due to the susceptibility artifact. Adverse effects were not documented.
Initiate test loop irradiations of ALSEP process solvent (2014)

This report describes the initial results of the study of the impacts of gamma radiolysis upon the efficacy of the ALSEP process and is written in completion of milestone M3FT-14IN030202. Initial irradiations, up to 100 kGy absorbed dose, of the extraction section of the ALSEP process have been completed. The organic solvent used for these experiments contained 0.05 M TODGA and 0.75 M HEH[EHP] dissolved in n-dodecane. The ALSEP solvent was irradiated while in contact with 3 M nitric acid and the solutions were sparged with compressed air in order to maintain aerated conditions. The irradiated phases were used for the determination of americium and europium distribution ratios as a function of absorbed dose for the extraction and stripping conditions. Analysis of the irradiated phases in order to determine solvent composition as a function of absorbed dose is ongoing. Unfortunately, the failure of analytical equipment necessary for the analysis of the irradiated samples has made the consistent interpretation of the analytical results difficult. Continuing work will include study of the impacts of gamma radiolysis upon the extraction of actinides and lanthanides by the ALSEP solvent and the stripping of the extracted metals from the loaded solvent. The irradiated aqueous and organic phases will be analyzed in order to determine the variation in concentration of solvent components with absorbed gamma dose. Where possible, radiolysis degradation product will be identified.
An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery (2022)

Drug development is a complex process that requires multidisciplinary teamwork to overcome the uncertainty associated to the process. From this point, problem-based learning (PBL) methodologies are helpful to train future professionals dedicated to drug development in multidisciplinary environments. One of the strategies developed to design novel business models is Business Model Canvas (BMC), a strategy that has been widely employed in business schools, but not in scientific education. Thus, we wanted to verify if a BMC-like template was suitable for a PBL experience in the field of drug development using a blended-learning approach. The students of a research master subject were asked to create a joint project plan for the development of a novel drug for an unmet clinical need by making use of a BMC-like template as support for discussions on the project strategy, while combining online and face-to-face sessions. The methodology helped the students to learn about drug development, even in a blended-learning format. Most students considered that this methodology enhanced their participation in the working group and helped them to focus their arguments, proving that the employment of BMC-like templates is helpful to overcome the disadvantages of PBL experiences.
Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates (2023)

<b>AL-471</b>, the leading exponent of a class of potent HIV and enterovirus A71 (EV-A71) entry inhibitors discovered in our research group, contains four l-tryptophan (Trp) units bearing an aromatic isophthalic acid directly attached to the C2 position of each indole ring. Starting from <b>AL-471</b>, we (i) replaced l-Trp with d-Trp, (ii) inserted a flexible linker between C2 and the isophthalic acid, and (iii) substituted a nonaromatic carboxylic acid for the terminal isophthalic acid. Truncated analogues lacking the Trp motif were also synthesized. Our findings indicate that the antiviral activity seems to be largely independent of the stereochemistry (l- or d-) of the Trp fragment and also that both the Trp unit and the distal isophthalic moiety are essential for antiviral activity. The most potent derivative, <b>23</b> (<b>AL-534</b>), with the C2 shortest alkyl urea linkage (three methylenes), showed subnanomolar potency against different EV-71 clinical isolates. This finding was only observed before with the early dendrimer prototype <b>AL-385</b> (12 l-Trp units) but remained unprecedented for the reduced-size prototype <b>AL-471</b>. Molecular modeling showed the feasibility of high-affinity binding of the novel l-Trp-decorated branches of <b>23</b> (<b>AL-534</b>) to an alternative site on the VP1 protein that harbors significant sequence variation among EV-71 strains.
Development of high temperature strain gages (1973)

High temperature electric resistance wire strain gages were developed and evaluated for use at temperatures exceeding 922 K (1200 F). A special high temperature strain gage alloy (Fe-25Cr-7.5A1), designated BCL-3, was used to fabricate the gages. Pertinent gage characteristics were determined at temperatures up to 1255 K (1800 F). The results of the evaluation were reported in graphical and tabular form. It was concluded that the gages will perform satisfactorily at temperatures to at least 1089 K (1500 F) for at least one hour.
A missense mutation in the C. elegans src-2 tyrosine-protein kinase reduces brood size and enhances embryonic morphogenesis defects in src-1(RNAi) conditions (2023)

Goldenhar Syndrome is a rare congenital disorder characterized by hemifacial microsomia. Although select mutations have been mapped for this disorder, the genetic etiologies in the majority of cases remain unknown. A recent clinical report of a Goldenhar Syndrome patient identified a homozygous missense mutation in <i>FRK</i> , a gene associated with various types of cancer. In this work, we precisely modeled the disease-associated missense mutation in the <i>C. elegans</i> FRK ortholog <i>src-2 ,</i> using CRISPR/Cas9 gene editing, and investigated the physiological role of this mutation and the <i>src-2</i> gene. In addition, we generated a conserved variant in <i>src-1</i> ( <i>FYN</i> ortholog) to assess the functional redundancy of the conserved variant. The putative pathogenic variants <i>src-1 (Val190Ile)</i> or <i>src-2 (Val170Ile)</i> caused only subtle phenotypes, suggesting that these mutations alone are not sufficient to explain the facial deformities observed in the Goldenhar Syndrome patient. However, the <i>src-2 (Val170Ile)</i> mutant exhibited reduced brood size and moderately enhanced embryonic developmental phenotypes, including epidermal and neuronal patterning defects, in the <i>src-1 (RNAi)</i> condition, indicating that the <i>src-2 (Val170Ile)</i> locus could play a supportive role during developmental processes. Overall, however, these studies showed that <i>src-1 /FYN</i> is essential for regulating embryogenesis and morphogenesis, while <i>src-2 /FRK</i> is largely dispensable for normal embryonic development, suggesting <i>FYN</i> , not <i>FRK</i> , is the dominant non-receptor protein kinase during embryonic development in <i>C. elegans</i> .
Worst-Case Optimal Radix Triejoin (2019)

Relatively recently, the field of join processing has been swayed by the discovery of a new class of multi-way join algorithms. The new algorithms join multiple relations simultaneously rather than perform a series of pairwise joins. The new join algorithms satisfy stronger worst-case runtime complexity guarantees than any of the existing approaches based on pairwise joins -- they are worst-case optimal in data complexity. These research efforts have resulted in a flurry of papers documenting theoretical and some practical contributions. However, there is still the quest of making the new worst-case optimal join algorithms truly practical in terms of (1) ease of implementation and (2) secondary index efficiency in terms of number of indexes created to answer a query. In this paper, we present a simple worst-case optimal multi-way join algorithm called the radix triejoin. Radix triejoin uses a binary encoding for reducing the domain of a database. Our main technical contribution is that domain reduction allows a bit-interleaving of attribute values that gives rise to a query-independent relation representation, permitting the computation of multiple queries over the same relations worst-case optimally without having to construct additional secondary indexes. We also generalise the core algorithm to conjunctive queries with inequality constraints and provide a new proof technique for the worst-case optimal join result.
Réactivité de l’acide déhydroacétique hydrogené en c5-c6 : obtention des pyrano-1,5-benzodiazépines différemment substituées et de la structure enaminone (2012)

Quelques dérivés originaux de structure 1,5-benzodiazépine 4 ont été obtenus par réaction de l’acide déhydroacétique (DHA) hydrogéné en C 5 -C 6 avec des orthophénylènediamines et des aldéhydes aromatiques. L’interprétation des résultats obtenus est enrichie par une étude de l’influence des effets électroniques de la réaction d’hydrogénation du DHA en C 5 -C 6 . En conséquence, cela nous conduit à l’obtention d’une structure énaminone originale 5 susceptible de fournir d’innombrables structures hétérocycliques à différents chaînons.
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study (1997)

The authors tested the hypothesis that proton magnetic resonance spectroscopic ( 1 H-MRS) imaging can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of low- to high-grade malignant transformation or posttherapeutic recurrence. Twenty-seven patients with cerebral gliomas verified on histological examination were studied repeatedly with 1 H-MRS imaging over a period of 3.5 years. At the time of each 1 H-MRS imaging study, clinical examination, MR imaging, positron emission tomography with 18 F-fluorodeoxyglucose, and biopsy findings (when available) were used to categorize each patient as having either stable or progressive disease. Measures of the percentage changes in the choline (Cho) 1 H-MRS imaging signal intensity between studies, which were obtained without knowledge of the clinical categorization, allowed the investigators to segregate the groups with a high degree of statistical significance. All progressive cases showed a Cho signal increase between studies of more than 45%, whereas all stable cases showed an elevation of less than 35%, no change, or even a decreased signal. The authors conclude that increased Cho levels coincide with malignant degeneration of cerebral gliomas and therefore may possibly be used as a supportive indicator of progression of these neoplasms.
Effects of Round Window Dexamethasone on Residual Hearing in a Guinea Pig Model of Cochlear Implantation (2007)

Short-term preoperative delivery of dexamethasone through the round window can protect residual hearing during cochlear implantation, especially during technically difficult surgery.
Reaction between Phenols and Isoprene under Zeolite Catalysis. Highly Selective Synthesis of Chromans and o-Isopentenylphenols (1998)

heterogeneous catalysis - zeolite HSZ-360 - isoprene - chromans - ortho-isopentenylphenols
Comparison of anterolateral and posterior approaches in the management of thoracolumbar burst fractures (2006)

Rigid guidelines for the selection of anterior or posterior approaches are lacking. Evaluation of the authors' results and those of others shows that angular deformity is more successfully corrected and maintained when the anterior approach is used.
The Effects of Speckle on Resolution of High Contrast and Continuous Tone Objects. (1976)

The effect of speckle in the imaging of diffusely illuminated gratings and continuous tone objects was studied. It was found that when imaging diffuse gratings the aperture of a coherently illuminated system must be 2.6 times as large as that of an incoherent system to obtain comparable resolution. This factor must be increased to five when imaging objects with a continuous spatial frequency distribution and range of contrast and to a factor of seven if the coherent image is subsequently low-pass filtered. A coherent system can achieve resolution which is comparable to an incoherent system of equal aperture if the coherent image is smoothed so that the mean to standard deviation ratio is ten or more. (Author)
Involvement of inflammatory cells in the dorsal root ganglion in oxaliplatin-induced neuropathic pain (2022)

Oxaliplatin is a platinum-based chemotherapeutic agent treating colorectal and gastric cancer. The most common dose-limiting adverse event of oxaliplatin treatment is chronic neuropathic pain, while the detailed mechanisms remain unknown. The present study investigated the molecular mechanisms of microglial regulation of the oxaliplatin-induced neuropathic pain. Intrathecal (I.t.) treatment with inducible nitric oxide synthetase (iNOS) inhibitor 1400W attenuated the oxaliplatin-induced cold and mechanical hypersensitivity. In addition, pharmacological and chemogenetical inhibition of macrophage/microglia also attenuated the oxaliplatin-induced cold and mechanical hyperalgesia. I.t. treatment with STAT3 inhibitor stattic attenuated the oxaliplatin-indued cold and mechanical hypersensitivity. Oxaliplatin induced the increased phosphorylation of neural STAT3 in the dorsal root ganglion (DRG), which was attenuated by i.t. pretreatment with 1400W. Since STAT3 phosphorylation was regulated by PTEN, effects of oxaliplatin on the PTEN activity in the DRG were examined. PTEN expression was decreased by oxaliplatin treatment. Our present study suggested that oxaliplatin induces neural STAT3 activation through the iNOS induction by macrophage/microglial activation in the DRG, which resulted in the oxaliplatin-induced neuropathic pain.
SlickFlow: Resilient source routing in Data Center Networks unlocked by OpenFlow (2013)

Recent proposals on Data Center Networks (DCN) are based on centralized control and a logical network fabric following a well-controlled baseline topology. The architectural split of control and data planes and the new control plane abstractions have been touted as Software-Defined Networking (SDN), where the OpenFlow protocol is one common choice for the standardized programmatic interface to data plane devices. In this context, source routing has been proposed as a way to provide scalability, forwarding flexibility and simplicity in the data plane. One major caveat of source routing is network failure events, which require informing the source node and can take at least on the order of one RTT to the controller. This paper presents SlickFlow, a resilient source routing approach implemented with OpenFlow that allows fast failure recovery by combining source routing with alternative path information carried in the packet header. A primary and alternative paths are compactly encoded as a sequence of segments written in packet header fields. Under the presence of failures along a primary path, packets can be rerouted to alternative paths by the switches themselves without involving the controller. We evaluate SlickFlow on a prototype implementation based on Open vSwitch and demonstrate its effectiveness in a Mininet emulated scenario for fat-tree, BCube, and DCell topologies.
Founding and Growing Adobe Systems, Inc. (2019)

Founded in 1982, Adobe Systems heralded several of the technological innovations necessary to precipitate the emergence of desktop publishing as well as many features of modern office computing, digital media, and graphic arts. In this paper, Adobe founders Charles Geschke and John Warnock cover their professional history, the conception of Adobe Systems, and its growth. They also explain the technology behind the advances in computer printing, electronic file transfer, and digital art and photography. Adobe, its products, and its engineers played a key role in these developments, which enabled desktop publishing and the publishing revolution.
Th17 Cytokines and the Gut Mucosal Barrier (2010)

Local immune responses serve to contain infections by pathogens to the gut while preventing pathogen dissemination to systemic sites. Several subsets of T cells in the gut (T-helper 17 cells, gammadelta T cells, natural killer (NK), and NK-T cells) contribute to the mucosal response to pathogens by secreting a subset of cytokines including interleukin (IL)-17A, IL-17F, IL-22, and IL-26. These cytokines induce the secretion of chemokines and antimicrobial proteins, thereby orchestrating the mucosal barrier against gastrointestinal pathogens. While the mucosal barrier prevents bacterial dissemination from the gut, it also promotes colonization by pathogens that are resistant to some of the inducible antimicrobial responses. In this review, we describe the contribution of Th17 cytokines to the gut mucosal barrier during bacterial infections.
Total Syntheses of the Tylophora Alkaloids Cryptopleurine, (−)‐Antofine, (−)‐Tylophorine, and (−)‐Ficuseptine C (2006)

A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer cell lines. The advantages of the chosen route are illustrated by the total syntheses of the phenanthroquinolizidine cryptopleurine (1) and the phenanthroindolizidines (-)-antofine (2), (-)-tylophorine (3), and their only recently isolated congener (-)-ficuseptine C (4). The key steps consist in a Suzuki cross-coupling between a (commercial) boronic acid and a simple aryl-1,2-dihalide followed by elaboration of the resulting products into the corresponding 2-alkynyl-biphenyl derivatives 27, 33, 41 and 46. The latter undergo PtCl2-catalyzed cycloisomerizations with formation of the functionalized phenanthrenes 28, 34, 42 and 47, which were transformed into the targeted alkaloids by a deprotection/Pictet-Spengler annulation tandem. Due to the flexibility and robust character of this approach, it might enable a systematic exploration of the pharmacological profile of this promising class of bioactive natural products.
Scaling directions for 2D and 3D NAND cells (2012)

This paper describes NAND cell scaling directions for 20nm and beyond. Many of the 2D NAND cell scaling challenges can be resolved by a planar floating gate (FG) cell. Scaling directions and key technology requirements for 3D NAND are also discussed.
Gas formation in the pleural space of a child with an anaerobic streptococcal pneumonia and empyema. (1982)

Anaerobic pleuropulmonary infections are common in adults1 but are unusual in children.2 Since the advent of antimicrobial chemotherapy, intrathoracic gas formation associated with these infections in children has not, to our knowledge, been reported.3 The purpose of this report is to describe a severe anaerobic streptococcal pneumonia and empyema with gas formation in a 9-year-old child and to review the diagnostic considerations stimulated by the presence of intrathoracic air-fluid levels. CASE REPORT A 9-year old white girl was transferred to the Primary Children9s Medical Center, University of Utah for treatment of an apparent lung abscess. Thirteen days prior to transfer this previously healthy girl had been admitted to another hospital with a one-day history of lower midabdominal pain.
Learning search tasks in queries and web pages via graph regularization (2011)

As the Internet grows explosively, search engines play a more and more important role for users in effectively accessing online information. Recently, it has been recognized that a query is often triggered by a search task that the user wants to accomplish. Similarly, many web pages are specifically designed to help accomplish a certain task. Therefore, learning hidden tasks behind queries and web pages can help search engines return the most useful web pages to users by task matching. For instance, the search task that triggers query "thinkpad T410 broken" is to maintain a computer, and it is desirable for a search engine to return the Lenovo troubleshooting page on the top of the list. However, existing search engine technologies mainly focus on topic detection or relevance ranking, which are not able to predict the task that triggers a query and the task a web page can accomplish.
Bromobis(dimethyldithiocarbamato)(4-methoxyphenyl)tellurium(IV) Dichloromethane Hemisolvate, p-MeOC6H4Te(Me2NCS2)2Br.0.5CH2Cl2 (1996)

The structure of the title TeIV complex, C13H19BrN2OS4Te.045(CH2Cl2), is pentagonal bipyramidal with four S atoms [Te—S 2.623 (1)–2.717 (1) Å] and the Br atom [Te—Br 2.890 (1) Å] in equatorial positions. The p-methoxyphenyl group is axial [Te—C 2.145 (3) Å] and the second axial position seems to be occupied by a dithiocarbamate group of a neighbouring molecule acting as a π-ligand [Te⋯C 3.751 (3) Å, C—Te⋯C 170.2 (1)°], so that molecules are joined into centrosymmetric associations by this secondary coordination.
Synthesis and crystal structure of the titanium tetrachloride-ethyl propionate adduct (1991)

Article Synthesis and crystal structure of the titanium tetrachloride-ethyl propionate adduct was published on August 1, 1991 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 194, issue 1-4).