gebhart/patrepeval huggingface dataset:
A rapid and precise method for the determination of vitamin D3 in rat skin by high-performance liquid chromatography. (1979)

In order to develop the investigations into photobiogenesis of vitamin D3, a rapid and precise method for the determination of the vitamin in rat skin was established by using high-performance liquid chromatography (HPLC). The proposed method included saponification of small pieces of rat skin, extraction of the unsaponifiable matter and application to HPLC using "Zorbax SIL" (straight-phase) as an adsorbent and 0.5% isopropanol in n-hexane as a mobile phase. The applicable lower limit of the method was 2ng of vitamin D3/cm2 of subcutaneous tissue-removed skin and it was possible to assay a concentration higher than 2 ng/cm2. The proposed method was applied to determine the content of vitamin D3 in rat skin obtained from in vivo and in vitro irradiation experiments. In the in vitro experiment, the yield of vitamin D3 increased in proportion to the irradiation time. On the other hand, the yield in the in vivo experiment showed a proportional increase similar to the in vitro experiment until 60 min irradiation, while a nearly constant value was obtained by irradiation for longer than 60 min. When the rat skin obtained from the in vitro experiment was irradiated with monochromatic UV rays in the range s60-350 nm, the most effective wavelength for the formation of vitamin D3 was confirmed to be 303 nm, which differs from the result obtained from the experiment in a test tube (295 nm). Moreover, the yield of vitamin D3 by irradiation with UV rays below 288 nm was extremely low, which again differed from the results of a test tube experiment. These differences were thought to be due to the filter effect of the malpighian layer in the epidermis of rat skin.
Suppression of Ovulation in the Rat by an Orally Active Antagonist of Luteinizing Hormone-Releasing Hormone (1982)

A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.
Tear film stability and tear surface tension (1989)

Surface tension has been measured by the method of Ferguson and Kennedy on small (0.3-0.4 microliter) samples of tears from 65 normal and 35 dry eyes. Non-invasive break-up time (NIBUT) was also measured on the same patients as an indication of tear film stability. The mean (+/- SD) surface tension value was 43.6 +/- 2.7 mN/m for normals, and 49.6 +/- 2.2 mN/m for dry eyes. All NIBUT values for dry eyes were below 20 sec (8.9 +/- 5.1 sec, mean +/- SD, n = 35) while 53% of normal values were 30 sec or over. A negative correlation was found between surface tension and NIBUT for both dry eyes and normals. Comparison of surface tension results for tears and a variety of standard solutions indicated that mucus makes the greatest contribution, even at low concentrations, but the effect of proteins can be large, especially in inflammatory states where serum proteins leak from conjunctival vessels. The measurement of surface tension is simple and direct, and in conjunction with the NIBUT value can help in classification of tear quality in questionably dry eye cases.
Pathophysiology & genetics of obstructive sleep apnoea. (2010)

Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.
Polarimetric characterization of debris and faults in the highway environment at millimeter-wave frequencies (2000)

In this paper, measurements and models for the polarimetric backscatter response of various paint targets on roads and road surface faults are presented. Of particular interest are debris and faults that could lead to fatal accidents and damage of property. A desired safety feature for automotive radar sensors is the capability of detecting such debris and faults. The detectability of a point target is evaluated by comparing its RCS value with the RCS threshold value defined by the backscatter response of the road surface. Extensive backscatter measurements at W-band were conducted to obtain the backscatter response of typical debris and faults on asphalt surfaces at near grazing incidence angles (76/spl deg/-86/spl deg/). On the other hand, theoretical models, based on diffraction from impedance wedges and scattering from impedance cylinders, respectively, as well as physical optics approximation, were developed to predict the backscatter response of road surface faults and targets with planar facets on road surfaces. Experimental results indicate that detectability in all cases is a function of target size, its azimuthal angle with respect to radar boresight, and the polarization state of the system. The measured backscatter response is used to verify the validity of the theoretical models. Angular polarimetric backscatter measurements of targets defining roadside boundaries such as a concrete curb, a guardrail, and a pebble surface are also presented. The results of these measurements could be used to alert fatigued drivers should their vehicles be heading sideward.
Examining the Effects and Feasibility of a Teacher-Implemented Tier 1 and Tier 2 Intervention in Word Reading, Fluency, and Comprehension (2017)

This study investigates the effects and feasibility of an intervention for first-grade students at risk for reading difficulties or disabilities (RD). The intervention was provided by general education classroom teachers and consisted of 15 min whole-class comprehension lessons (Tier 1) and 30 min Tier 2 intervention sessions in word reading, comprehension, and text reading. First-grade teachers (n = 21), with 4–5 students at risk for reading difficulties and potential reading disability were randomly assigned to treatment or typical practice comparison conditions. Significant group differences were detected on all measures of word reading, decoding, and fluency. Effect sizes were educationally important for all measures of word reading, decoding, and reading comprehension; however, effects on standardized measures were smaller than those in prior studies with similar students in which intervention was typically provided outside the regular classroom. An exploratory analysis indicated that students at different parts of the pretest and posttest distributions responded more and less positively to the intervention, providing insights that may help guide future revisions. The study provides preliminary evidence of the intervention's promise for positively impacting student outcomes.
Activated Platelet-Rich Plasma Improves Fat Graft Survival in Nude Mice: A Pilot Study (2011)

PRP treatment improved the survival and quality of fat grafts. Safer methods of PRP activation and preparation should be further investigated for potential application in humans.
Mixed Lateralization of Phonological Assembly in Developmental Dyslexia (2002)

Developmental phonological dyslexia has been characterized as a deficit in phonological assembly. At a neural level, it is possible that this deficit is represented by weak connectivity between anterior and posterior language systems in the left hemisphere. This study used 3-Tesla functional magnetic resonance imaging to investigate phonological assembly in a developmental phonological dyslexic. The phonological dyslexic showed increased activation in the left hemisphere of the inferior frontal gyrus (BA 44/6) and increased activation in the right hemisphere of the parietal cortex (BA 7), occipital cortex (BA 18), and in the cerebellum, as phonological demands were systematically increased. Converging evidence suggests that the core dysfunction in phonological dyslexia resides in and around the angular gyrus of the left hemisphere. This study supports the compensatory role of posterior regions in the right hemisphere together with the left inferior frontal gyrus.
Target identification for repurposed drugs active against SARS-CoV-2 via high-throughput inverse docking (2021)

Screening already approved drugs for activity against a novel pathogen can be an important part of global rapid-response strategies in pandemics. Such high-throughput repurposing screens have already identified several existing drugs with potential to combat SARS-CoV-2. However, moving these hits forward for possible development into drugs specifically against this pathogen requires unambiguous identification of their corresponding targets, something the high-throughput screens are not typically designed to reveal. We present here a new computational inverse-docking protocol that uses all-atom protein structures and a combination of docking methods to rank-order targets for each of several existing drugs for which a plurality of recent high-throughput screens detected anti-SARS-CoV-2 activity. We demonstrate validation of this method with known drug-target pairs. We subjected 152 distinct drugs potentially suitable for repurposing to the inverse docking procedure. Detailed structural analysis revealed important insights and could potentially lead to more rational design of new drugs against these targets.
Design a Dual Polarizations MIMO Antenna Based on Decoupling Elements for 5G Smart-Phones (2023)

This paper suggests a compact linear and circular polarization MIMO antenna for sub-6 GHz 5G smartphones. The proposed design can be divided into three parts: Firstly, a linear polarized dipole antenna is presented with dimensions of 1×33.7×32.5mm3 and exhibits an impedance bandwidth (IBW) of 3.24GHz ranging from 3.3GHz to 6.6GHz at S11˂-10dB. The second part includes a circular polarization CPW-Fed antenna with dimensions of 1×23.2×30mm3. The IBW of the CPW antenna is more than 4GHz, starting from 3.9GHz to more than 8GHz at an S11˂-10dB. The 3-dB axial ratio for the CP CPW antenna ranges from 4GHz to 7.38GHz. Finally, a combination of LP and CP antennas is presented to form a dual polarization MIMO system. A MIMO system consists of 5 elements; 4 elements are LP and 1 element is a CP antenna. The size of the MIMO system is 1×82.5×150mm3 printed on an FR-4 substrate. Two impedance bandwidths are found due to the use of two antenna types. The first one (S11, S22, S44, S55) equals 3.44GHz while the second (S33) equals 4.33GHz. HFSS is used for designing and simulating the proposed structures, while CST is used for verifying the results.
Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor (1995)

The wild type insulin-like growth factor I (IGF-I) receptor has both mitogenic and transforming activities. We have examined the effect of point mutations at tyrosine residues 1250 and 1251 on these two properties of the receptor. For this purpose, we stably transfected plasmids expressing mutant and wild type receptors into R- cells, which are 3T3-like cells, derived from mouse embryos with a targeted disruption of the IGF-I receptor genes, and therefore devoid of endogenous IGF-I receptors. A tyrosine to phenylalanine mutation of either the 1250 or 1251 residue, or both, has no effect on the ability of the receptor to transmit a mitogenic signal. However, the tyrosine 1251 mutant receptor and the double mutant have lost the ability to transform R- cells (colony formation in soft agar), even when the receptors are expressed at very high levels, while the Y1250F mutant is fully transforming. These experiments show that the 1251 tyrosine residue is required for the transforming activity of the IGF-I receptor.
Atmospheric wind and temperature profiles inversion using infrasound: An ensemble model context (2020)

This paper presents an inversion methodology where acoustic observations of infrasound waves are used to update an atmospheric model. This paper sought a flexible parameterization that permits to incorporate physical and numerical constraints without the need to reformulate the inversion. On the other hand, the optimization conveys an explicit search over the solution space, making the solver computationally expensive. Nevertheless, through a parallel implementation and the use of tight constraints, this study demonstrates that the methodology is computationally tractable. Constraints to the solution space are derived from the spread (variance) of ERA5 ensemble reanalysis members, which summarize the best current knowledge of the atmosphere from assimilated measurements and physical models. Similarly, the initial model temperature and winds for the inversion are chosen to be the average of these parameters in the ensemble members. The performance of the inversion is demonstrated with the application to infrasound observations from an explosion generated by the destruction of ammunition at Hukkakero, Finland. The acoustic signals are recorded at an array station located at 178 km range, which is within the classical shadow zone distance. The observed returns are assumed to come from stratospheric reflections. Thus, the reflection altitude is also an inverted parameter.
Maize floral regulator protein INDETERMINATE1 is localized to developing leaves and is not altered by light or the sink/source transition (2006)

The INDETERMINATE1 gene, ID1, encodes a putative transcription factor that plays an important role in regulating the transition to flowering in maize. Mutant id1 plants have a prolonged vegetative growth phase and fail to make normal flowers. The ID1 gene, which encodes a nuclear-localized zinc finger protein, is expressed exclusively in immature leaves, suggesting that ID1 regulates a leaf-derived floral inductive signal. It is shown by western analysis with anti-ID1-specific antibody that ID1 co-localizes with ID1 mRNA in developing, immature leaves and, similarly, is absent in mature, photosynthetically active leaf blades, as well as the shoot apical meristem. Immunolocalization with anti-ID1 antibody shows that ID1 protein is detected in the nuclei of all cell types in immature leaves. Examination of plants grown in different day/night cycles revealed that ID1 gene expression and protein levels are largely unaffected by variations in light and dark, and that mRNA and protein levels do not follow a circadian pattern. The absence of ID1 expression in greening leaf tips coincides with the sink-to-source transition of developing leaves. It was found that ID1 levels are down-regulated in mature albino leaves similarly as in normal green leaves, suggesting that ID1 activity is controlled developmentally and is not affected by the sink/source status of the leaf or the inability of a mature leaf to engage in photosynthesis. The finding that ID1 expression is developmentally regulated and is unperturbed by external stimuli such as photoperiod supports the supposition that ID1 acts through the autonomous floral inductive pathway in maize.
Monolithically Integrated BiVO4/Si Tandem Devices Enabling Unbiased Photoelectrochemical Water Splitting (2023)

Abstract A photoelectrochemical (PEC) water splitting device based on a dual‐junction monolithic tandem cell that utilizes NiOOH/FeOOH/BiVO 4 /SnO 2 /Ta:SnO 2 (TTO)/tunnel oxide passivated contact (TOPCon) Si is reported. The PEC device achieves a maximum photocurrent density of 1.4 mA cm −2 (equal to a solar‐to‐hydrogen conversion efficiency of 1.72%) in 1.0 m potassium borate solution (pH 9) when illuminated with air mass 1.5 G simulated solar irradiation, which is the highest value among dual‐junction monolithic photoelectrochemical cells except for III–V materials. The TOPCon Si not only works as an appropriate bottom photoelectrode for subsequent high‐temperature BiVO 4 processing but also offers a high photovoltage of 590 mV. Transparent and conductive TTO grown by pulsed laser deposition serves as a recombination layer to achieve effective integration. In addition, the TTO provides chemical and physical protection, allowing the surface of the TOPCon Si to exhibit 24 h of tandem cell stability under weak base electrolyte conditions. The SnO 2 hole‐blocking layer inserted between TTO and BiVO 4 enhances the charge separation of BiVO 4 , allowing the device to achieve high efficiency. Artificial leaf‐type monolithic tandem cells consisting of NiFe/BiVO 4 /SnO 2 /TTO/TOPCon Si/Ag/Ti/Pt with a solar‐to‐hydrogen efficiency of 0.44% are also demonstrated.
Investigation of Dynamic and Control of Robots’ Cooperation in Assembling Process (2014)

Assembling and fitting parts together can be considered as one of the most practical but also challenging process in robotics. Various applications are conceivable such as spatial ones where accessibility is reduced or in construction fields where huge forces have to be dealt with in a meticulous manner. In this paper, the cooperation of two robots during the complete assembling process of two structural parts from the approaching phase to the fitting stage is investigated. In the approaching phase for taking the parts closer, the two large construction parts may collide due to the inertia of motion, causing considerable impact forces even with the slightest relative velocity. This issue presents important control challenges as the effects of this local impact may be transferred throughout the system’s frame, affecting all other elements and inducing instability. Finally after connection of these two parts is established, the whole frame is transported to any desired location by cooperative operation of the two robots. Each step requires a particular controller to deal with different system’s dynamics that occur during the whole process.
Proceedings of the Workshop on Negation and Speculation in Natural Language Processing (2010)

These proceedings contain the papers and invited talks presented at the Workshop on Negation and Speculation in Natural Language Processing (NeSp-NLP 2010) that was held on the 10th of July, 2010 in Uppsala, Sweden. The program consisted of five invited talks, seven presentations of long papers and two of short papers.

When we thought of organising this workshop, we aimed at bringing together researchers working on negation and speculation from any area related to computational language learning and processing. Specific goals were to describe the lexical aspects of negation and speculation, to define how the semantics of these phenomena can be modelled for computational purposes, to explore techniques aimed at learning the factuality of an statement, and to analyse how the treatment of these phenomena affects the efficiency of Natural Language Processing (NLP) applications.

Negation and speculation are two linguistic phenomena involved in deep understanding of text. They are resources used to express the factuality of statements, which indicates to which extent a statement is or is not a fact. Negation turns an affirmative statement into negative (it rains/it does not rain). Speculation is used to express levels of certainty (it might rain/apparently, it will rain/ it is likely to rain/it is not clear whether it will rain/we suspect that it will rain). We knew that negation and speculation (or modality) have been extensively studied from a theoretical perspective. Furthermore, we also believed that there was enough interest on these topics among the NLP community and that there was enough research going on, so as to organise a topical workshop, the first of its kind as far as we know.
Universal and ultrafast quantum computation based on free-electron-polariton blockade (2023)

Cavity quantum electrodynamics (QED), wherein a quantum emitter is coupled to electromagnetic cavity modes, is a powerful platform for implementing quantum sensors, memories, and networks. However, due to the fundamental tradeoff between gate fidelity and execution time, as well as limited scalability, the use of cavity-QED for quantum computation was overtaken by other architectures. Here, we introduce a new element into cavity-QED - a free charged particle, acting as a flying qubit. Using free electrons as a specific example, we demonstrate that our approach enables ultrafast, deterministic and universal discrete-variable quantum computation in a cavity-QED-based architecture, with potentially improved scalability. Our proposal hinges on a novel excitation blockade mechanism in a resonant interaction between a free-electron and a cavity polariton. This nonlinear interaction is faster by several orders of magnitude with respect to current photon-based cavity-QED gates, enjoys wide tunability and can demonstrate fidelities close to unity. Furthermore, our scheme is ubiquitous to any cavity nonlinearity, either due to light-matter coupling as in the Jaynes-Cummings model or due to photon-photon interactions as in a Kerr-type many-body system. In addition to promising advancements in cavity-QED quantum computation, our approach paves the way towards ultrafast and deterministic generation of highly-entangled photonic graph states and is applicable to other quantum technologies involving cavity-QED.
Exploring the Origin of Blue and Ultraviolet Fluorescence in Graphene Oxide (2013)

We studied the fluorescence (FL) properties of highly exfoliated graphene oxide (GO) in aqueous solution using continuous-wave and time-resolved FL spectroscopy. The FL spectra of highly exfoliated GO showed two distinct peaks at ∼440 (blue) and ∼300 nm [ultraviolet (UV)]. The FL of GO in the UV region at ∼300 nm was observed for the first time. The average FL lifetimes of the emission peaks at ∼440 and ∼300 nm are 8-13 and 6-8 ns, respectively. The experimentally observed peak wavelengths of pH-dependent FL, FL excitation spectra, and the FL lifetimes are nearly coincident with those of aromatic compounds bound with oxygen functional groups, which suggests that the FL comes from sp(2) fragments consisting of small numbers of aromatic rings with oxygen functional groups acting as FL centers in the GO.
Template Free Architecture of Hierarchical Nanostructured ZnIn2S4 Rose-Like Flowers for Solar Hydrogen Production (2017)

We have demonstrated the controlled synthesis of hierarchical nanostructured ZnIn₂S₄ using a facile template free hydrothermal/solvothermal method. The effect of solvents on the morphology and microstructure of ZnIn₂S₄ has been studied by using water, methanol and ethylene glycol as a solvents. The hierarchical nanostructure, i.e., rose-like morphology composed of very thin (5–6 nm) nanoplates of length ˜1 μm which was obtained in aqueous mediated ZnIn₂S₄. The porous structure (distorted flowers) and agglomerated nanoparticles were obtained using methanol-and ethylene glycol-mediated ZnIn₂S₄. Considering the band gap in the visible region, ZnIn₂S₄ is used as a solar light driven photocatalyst. An ecofriendly photocatalytic process for the conversion of poisonous H₂S into H₂ which is a green unconventional energy source has been demonstrated. The nanostructured ZnIn₂S₄ is employed as a photocatalyst for hydrogen production from H₂S via a solar light-driven eco-friendly approach. The stable photocatalytic activity of hydrogen evolution, i.e., 3964 μmol ⁻¹ was obtained using 0.5 gm of such hierarchical nanostructured ZnIn₂S₄ under visible light irradiation. The unique hierarchical nanostructured ZnIn₂S₄ ternary semiconductor having hexagonal layer is expected to have potential applications in solar cells, LEDs, charge storage, electrochemical recording, thermoelectricity, other prospective electronic and optical devices.