gebhart/patrepeval huggingface dataset:
32 Bacterial Communities in the Uterus and Rumen of Beef Heifers Throughout Development with Protein Supplementation (2022)

Abstract Protein supplementation to replacement heifers is utilized to reach targeted body weights, which may affect the animal’s gut and reproductive microbiomes and potentially impact breeding outcomes. The objective of the study was to evaluate the effects of protein supplementation on the ruminal and uterine bacterial communities of developing heifers. Thirty-nine pre-pubertal commercial Angus heifers were blocked by body weight (BW) and randomly assigned to one of three supplementation groups: 10% crude protein (CP), 20% CP, or 40% CP. Supplements were provided four times weekly for 140d. Blood and BW were taken every 14d to monitor development. Every 56d, uterine flushes and rumen content were collected for bacterial identification. Uterine flushes were collected via 20 mL sterile saline flushed through a Foley catheter, and rumen content by esophageal tubing. Bacterial DNA was extracted and amplified targeting the V1-V3 region of the 16S rRNA gene. Microbiome analyses were performed in R 4.1 with dada2 and phyloseq packages. Statistical analyses were performed in R and SAS 9.4. The GLIMMIX procedure was used including fixed effects of protein, month, and pubertal status. Random effects included BW, interaction of BW and protein, and heifer within the interaction, with repeated measures of month. Alpha diversity differed by month in the rumen, and by month and pubertal status in the uterus (P &amp;lt; 0.05). Bray Curtis analyses indicated clustering by month and pubertal status (P &amp;lt; 0.001) in the uterus, and by month in the rumen (P &amp;lt; 0.001). Multiple uterine and ruminal bacteria abundances differed over time and by protein supplementation and pubertal status (P &amp;lt; 0.05). The impact of pubertal status and month of development may indicate maturation of the uterine bacterial communities through development. Protein supplementation affecting the uterine bacterial communities may provide opportunity to manipulate the uterine microbiome, potentially affecting future reproductive success.
Inhibition of murine hepatoma tumor growth by cryptotanshinone involves TLR7-dependent activation of macrophages and induction of adaptive antitumor immune defenses (2019)

Cryptotanshinone (CT), a purified compound initially isolated from the dried roots of Salvia militorrhiza. Bunge, exhibits cytotoxic antitumor effects on many tumors. We have shown that CT possesses the dual capacities to concomitantly inhibit the proliferation of lung cancer cells and promote the generation of antitumor immunity. In this study, we investigated whether CT could be used to treat hepatocellular carcinoma (HCC) using a mouse Hepa1-6 model. CT inhibited the proliferation of mouse hepatoma (Hepa1-6) cells in vitro by inducing Hepa1-6 cells apoptosis through the JAK2/STAT3 signaling pathway. In addition, CT activated macrophages and polarized mouse bone marrow-derived macrophages (BMM) toward an M1 phenotype in vitro, which depended on the TLR7/MyD88/NF-κB signaling pathway. Furthermore, CT significantly inhibited the growth of syngeneic Hepa1-6 hepatoma tumors, and, in combination with anti-PD-L1 cured Hepa1-6-bearing mice with the induction of long-term anti-Hepa1-6 specific immunity. Immunoprofiling of treated Hepa1-6-bearing mice revealed that CT-promoted activation of tumor-infiltrating macrophages and dendritic cells, induction of antitumor T cell response, and infiltration of effector/memory CD8 T cells in the tumor tissue. Importantly, the immunotherapeutic effects of CT and anti-PD-L1 depended on the presence of CD8 T cells. Thus, CT and anti-PD-L1 may provide an effective immunotherapeutic regimen for human HCC based on a combination of cytotoxic effects and induction of tumor-specific immunity.
Les Premiers Colons (1913)

Klein Henri. Les Premiers Colons. In: Les Feuillets d'El-Djezaïr, volume 6, 1913. Les rues de l'ancien et du nouvel Alger – L'esclavage européen. pp. 135-139.
Hyperadherence of anhhamutant ofEscherichia coliO157:H7 is correlated with enhanced expression of LEE-encoded adherence genes (2004)

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 virulence factors, specifically those conferring intimate adherence to and formation of attaching and effacing lesions (A/E) on host cells, are encoded by a horizontally acquired locus of enterocyte effacement (LEE). Expression of several LEE-encoded genes, which are organized into operons LEE1 through LEE5, is under the positive regulation of ler, the first gene in the LEE1 operon. We have recently demonstrated that EHEC O157:H7 lacking hha exhibited greater than a 10-fold increase in ler expression and that the repression of ler results from the binding of Hha to the ler promoter. In this report, we show that an hha mutant of EHEC O157:H7 exhibited increased adherence to Hep-2 cells, had increased transcriptional activities of LEE1, LEE2, LEE3, and LEE5 as determined by reverse transcriptase-polymerase chain reaction assays, and expressed LEE5::lac transcriptional fusion at levels that were several-fold higher than that expressed by the parental hha+ strain. These results demonstrate that hha is an important regulatory component of the cascade that governs the expression of LEE operons and the resulting ability of EHEC O157:H7 to intimately adhere to host cells.
On Analytical Modeling of the Air Gap Field Modulation in the Brushless Doubly Fed Reluctance Machine (2021)

The brushless doubly fed reluctance machine (BDFRM) is receiving an increased amount of attention from the research community thanks to its potential as an alternative drive for variable speed applications, both as motor and generator. Currently, the sizing of the BDFRM in the literature is based on the model of an ideal axially laminated rotor (ALR) and discrepancies are hidden in compensation factors which are in turn tuned with a finite element analysis (FEA). This paper proposes an analytical framework to accurately model the air gap field modulation, and by extension the torque density, of the BDFRM with ducted segmental rotor (DSR) and salient pole rotor (SPR). The results are verified with FEA and validated on a BDFRM prototype.
Screening air samples for polynuclear aromatic compounds: a field study (1983)

The use of simple and cost-effective luminescence techniques for screening air-particulate samples is described. Two analytical methods, synchronous luminescence and room-temperature phosphorescence, are employed to monitor the content of polynuclear aromatic species in air particulate extracts collected at a wood-burning community. The validity and efficacy of this cost-effective screening approach are demonstrated via comparison of the screening data with results obtained by detailed gas-chromatography/mass-spectrometry analysis.
The effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts (2007)

The effects of single-walled carbon nanotubes (SWNTs), double-walled carbon nanotubes (DWNTs) and multi-walled carbon nanotubes (MWNTs) on the proliferation, differentiation, adipocytic transdifferentiation and mineralization of primary osteoblasts were investigated. SWNTs, DWNTs and MWNTs with the same mean length of 5?15??m and various diameters were shown to reduce the viability of osteoblasts and inhibit the adipocytic trans-differentiation in a time-?and dose-dependent manner. The order of inhibition effect is SWNTs>DWNTs>MWNTs. Carbon nanotubes (CNTs) inhibited the formation of mineralized nodules greatly and dose-dependently during the final stage of osteoblast differentiation, revealing 50% decrease in the formation of mineralized nodules at the concentration of 50??g?ml?1. The expression of important proteins such as Runx-2 and Col-I in osteoblasts was also greatly inhibited upon interacting with CNTs. Transmission electron microscope (TEM) results revealed that the effects on cellular behavior may be exerted by the CNTs from inside and outside the cells.
Comparative study of the role of serum levels of p53 antigen and its tumor cell concentration in colon cancer detection. (1996)

The role of serum levels of p53 antigen in detection of colon cancer was studied in different groups of cancer and noncancer patients and was compared with the results of immunohistochemical analyses. The p53 antigen was isolated from the human serum as a cytoplasmic fraction using the recently described new type of columns for affinity chromatography, gel fiberglass columns (Zusman and Zusman, 1995). Its concentration was detected by high performance liquid chromatography. The serum level of the p53 antigen significantly increased in cancer patients (3.6 mg ml(-1)) as compared to its concentration in patients with benign tumors (1.7 mg ml(-1)) or in patients with noncancer disorders (0.49 mg ml(-1)), and this was found to be a result of higher concentration of p53 protein in tumor cells. Coefficient of correlation between cellular concentration of p53 protein and its serum level was 0.44 in noncancer lesions and 0.48 in cancer patients. Serum levels of p53 antigen was shown to be highly active either in patients with noncancer lesions or in patients with cancer (r = 0.46 and 0.51 respectively), whereas the cell determination of p53 protein was effective only among noncancer patients (r = 0.61) but not in cancer patients (r = 0.22). The findings suggests that serum determination of p53 antigen can perhaps reveal this oncoprotein already in the early stages of cancer or even predict the putative development of cancer. The possibility to use the serum-levels of p53 antigen in the follow up patients with chronic diseases and to detect transformation of these diseases into cancer, or monitoring former cancer patients in order to detect as early as possible the incidence of recurrent cancer is discussed.
Pyoluteorin, a synthesis (1970)

The synthesis of Pyoluteorin, an antibiotic from Pseudomonasaeruginosa is described. The method used produced in addition, an isomer 3,5-dichloro-2-(2′,6′-dihydroxybenzoyl)pyrrole, for which the name isopyoluteorin is proposed. The bromine analogue of pyoluteorin is also reported.
ACME: A New Mobile Content Delivery Architecture (2004)

This chapter develops a new architecture for content delivery in the mobile environment (ACME) that significantly accelerates content delivery over the radio link, which is usually the bottleneck of mobile user experience. A key concept used in ACME is user interest correlation, which identifies the similarity of interest in content between users. By exploiting user interest correlation, ACME pushes content to targeted mobile users with high accuracy to improve user experience. This system is suitable for mobile content delivery because of its high bandwidth- and terminal power-efficiency.
Diffusion of Ge in SiGe alloys (1974)

Germanium diffusion was measured in SiGe alloys of 100/0, 77.6/22.4, 69.2/30.8, 44.6/55.4, and 22.3/77.7 silicon to germanium atomic-percent ratios by the use of the radioisotope $^{71}\mathrm{Ge}$ and a thin-sectioning technique. As expected from the calculated, small, strain-energy contributions from the $^{71}\mathrm{Ge}$ impurities, the diffusion is similar to silicon self-diffusion for the silicon end member. Since the results fit an Arrhenius plot for the compositions and temperature ranges studied, activation energies and pre-exponentials were determined. These diffusion parameters indicate that the $^{71}\mathrm{Ge}$ diffusion is compatible with the monovacancy mechanism up to 70-at.% silicon in the SiGe alloys. For more silicon-rich material, the diffusion is quite analogous to the extended-defect mechanism previously suggested for high-temperature silicon self-diffusion.
Face Alignment Using Active Shape Model And Support Vector Machine (2012)

The Active Shape Model (ASM) is one of the most popular local texture models for face alignment. It applies in many fields such as locating facial features in the image, face synthesis, etc. However, the experimental results show that the accuracy of the classical ASM for some applications is not high. This paper suggests some improvements on the classical ASM to increase the performance of the model in the application: face alignment. Four of our major improvements include: i) building a model combining Sobel filter and the 2-D profile in searching face in image; ii) applying Canny algorithm for the enhancement edge on image; iii) Support Vector Machine (SVM) is used to classify landmarks on face, in order to determine exactly location of these landmarks support for ASM; iv)automatically adjust 2-D profile in the multi-level model based on the size of the input image. The experimental results on Caltech face database and Technical University of Denmark database (imm_face) show that our proposed improvement leads to far better performance.
Relation ship between fetal biophysical profile and fetal cord blood acid- base status obtained by cordocentesis (2002)

Objective : Fetal biophysical profile is widely used antenatal test for fetal wellbeing, but its biochemical background is not well known. The purpose of this study is to examine the relationship of fetal biophysical profile and cord blood acid base status including gas analysis using cord blood obtained by cordocentesis, by which the biochemical background of fetal biophysical profile can be understood. Study design : 121 pregnant women received cordocentesis for various indication, of whom the fetuses were evaluated with fetal biophysical profile just before the cordocentesis. Cord blood obtained by cordocentesis was analyzed for acid-base and gas status. The results of both tests were compared by appropriate statistical method. Results : Fetal biophysical profile showed definite correlation with the results of cord blood acid-base and gas analysis (p
ChemInform Abstract: Nitration of Aromatic Compounds (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimizing Pilot Planning and Training for Continental Airlines (2004)

The Crew ResourceSolver decision-support system employs advanced optimization modeling and solution techniques to solve complex, large-scale pilot staffing and training problems at Continental Airlines. The system determines optimal pilot transitions and efficiently allocates and schedules training resources. The results are improved staffing levels and substantial cost savings through reduced staffing, hiring, and training costs. Continental has estimated savings of over $10 million per year using the system.
Single-Cell Profiling in Multiple Myeloma: Insights, Problems, and Promises (2023)

In a short time, single-cell platforms have become the norm in many fields of research, including multiple myeloma (MM). In fact, the large amount of cellular heterogeneity in MM makes single-cell platforms particularly attractive because bulk assessments can miss valuable information about cellular subpopulations and cell-to-cell interactions. The decreasing cost and increasing accessibility of single-cell platform, combined with breakthroughs in obtaining multiomics data for the same cell and innovative computational programs for analyzing data, have allowed single-cell studies to make important insights into MM pathogenesis; yet, there is still much to be done. In this review, we will first focus on the types of single-cell profiling and the considerations for designing a single-cell profiling experiment. Then, we will discuss what have learned from single-cell profiling about myeloma clonal evolution, transcriptional reprogramming, and drug resistance, and about the MM microenvironment during precursor and advanced disease.
Cardiac Arrhythmias in Non-Intubated Children During Adenoidectomy. A Comparison Between Enflurane and Halothane Anaesthesia (1984)

SIGURDSSON, G. H.; CARLSSON, C.; LINDAHL, S.; WERNER, O.; Graves, Shirley A. M.D. Author Information
Advanced nickel-metal hydride cell development at Hughes: a joint work with US government (2002)

Hughes is currently engaged in the development of an advanced nickel-metal hydride (Ni/MHx) cell for spacecraft application with performance goals of 15 years of operation in a geosynchronous Earth orbit at 80% depth of discharge and over 30,000 cycles of life at 30% depth of discharge in a typical low Earth orbit. The authors have developed a basic fabrication technique for a lightweight and potentially long life nickel electrode which is useable in space Ni/MHx cells. They have developed several attractive hydride alloys which are useable in hydride electrodes and basic fabrication techniques for lightweight, inexpensive, and potentially long life hydride electrodes for a Ni/MHx cell. Utilizing Hughes extensive experiences in the development of advanced Ni/Cd and Ni/H/sub 2/ cells, they plan to develop a first generation space Ni/MHx cell design by 1995 and have the cell flight ready by 1997.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Using Evolutionary Algorithms for Signal Integrity Checks of High-Speed Data Buses (2007)

Today's high performance computer systems must have fast, reliable access to memory and I/O devices. Unfortunately, inter-symbol interference, transmission line effects and other noise sources can distort data transfers. Engineers must therefore determine if bus designs have signal integrity <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">.</i> e., the bus can transfer data with minimal amplitude or timing distortion. One method of determining signal quality on buses is to conduct a set of data transfers and measure various signal parameters at the receiver end. But the tests must be conducted with stressful test patterns that maximize inter-symbol interference to help identify any potential problems. In this paper we describe how an evolutionary algorithm was used to evolve such test patterns. All test results were obtained intrinsically
Medical Image Reconstruction Using Kernel Based Methods (2011)

The image reconstruction problem consists in finding an approximation of a function f starting from its Radon transform Rf. This problem arises in the ambit of medical imaging when one tries to reconstruct the internal structure of the body, starting from its X-ray tomography. The classical approach to this problem is based on the Back-Projection Formula. This formula gives an analytical inversion of the Radon transform, provided that all the values of Rf are known. In applications only a discrete set of values of Rf is given, thus, one can only obtain an approximation of f. Another class of methods, called ART, can be used to solve the reconstruction problem. Following the ideas contained in ART, we try to apply the Hermite-Birkhoff interpolation to the reconstruction problem. It turns out that, since the Radon transform of a kernel basis function can be infinity, a regularization technique is needed. The method we present here is then based on positive definite kernel functions and it is very flexible thanks to the possibility to choose different kernels and parameters. We study the behavior of the methods and compare them with classical algorithms.
High Mobility Field-Effect Thin Film Transistor Using Room-Temperature High-<formula formulatype="inline"><tex Notation="TeX">$\kappa$</tex> </formula> Gate Dielectrics (2014)

This paper reports an InGaZnO thin-film transistor (TFT) that involves using fully room-temperature gate dielectrics on a flexible substrate. The wide bandgap dielectrics of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{HfO}}_{2}$</tex> </formula> and <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{Y}}_{2}{\hbox{O}}_{3}$</tex> </formula> exhibited favorable adhesion properties on a flexible substrate compared with conventional low- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\kappa$</tex> </formula> <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{SiO}}_{2}$</tex> </formula> film. Based on the experimental results, the room-temperature <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{ IGZO/HfO}}_{2}$</tex></formula> TFTs demonstrated effective device integrity, and achieve a low drive voltage of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$&lt; {\hbox{2}}$</tex></formula> V, a low threshold voltage of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{0.46}} \pm {\hbox{006}}$</tex></formula> V, a low sub-threshold swing of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{110}} \pm {\hbox{6}}$</tex> </formula> mV/decade and an extremely high mobility of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">${\hbox{60.2}} \pm {\hbox{32}}$</tex></formula> cm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{2}/{\hbox{V}}\cdot{\hbox{s}}$</tex> </formula> . The excellent performance of this TFT indicated that it demonstrates considerable potential for active-matrix liquid crystal display applications requiring low power consumption and a high driving current.
Measurements of Microscopic Stresses in Si-Based Polycrystalline Ceramics (2005)

Many of the properties of Si-based ceramics, including their structural behavior, are strongly influenced by their micro/nanostructure and by the microscopic residual stress fields piled up during processing and/or usage. The electron beam, used as a sharp and reliable probe for high-resolution cathodoluminescence (CL) assessments, can routinely provide a suitable tool for assessing both the structural and the mechanical characteristics of Si-based ceramics on a sub-micrometer scale. Although the full development of stress-related CL techniques is still in embryo, we show here the possibility of assessing microscopic stress fields inside a field-emission gun scanning electron microscope (FEG-SEM). This new assessment takes advantage of the piezo-spectroscopic effect on selected bands of CL spectra and it is applied here to both β-silicon nitride (Si3N4) and β-silicon carbide (SiC) ceramics. CL spectra in both materials arise from their peculiar optically active defects. Experimental assessments of microstress fields may open a completely new perspective in the development of high-performance Si-based ceramics because one can directly visualize how residual stresses distribute within the material micro/nanostructure and miniaturized devices.
[Behavior of the erythrocyte glucose-6-phosphate dehydrogenase in patients with functional thyroid disorders and in hyperthyroxinemic rats]. (1979)

This paper deals with the activity of glucose-6-phosphate dehydrogenase in patients with hyper- and hypothyroidism as well as in hyperthyroxinaemic rats. The activity of glucose-6-phosphate dehydrogenase is enhanced in red blood cells of hyperthyreotic patients and hyperthyroxinaemic animals. The activity will be decreased to normal range in patients by administration of antithyreotic drugs, such as thiamazole. Patients with hypothyroidism exhibit decreased enzymatic activity. It is suggested that thyroid hormones stimulate the HMP-shunt in red blood cells as a defence mechanism against additional oxidative stress.