gebhart/patrepeval huggingface dataset:
ChemInform Abstract: A Divergent Synthesis of D‐ and L‐Carbocyclic 4′‐Fluoro‐2′,3′‐dideoxynucleosides as Potential Antiviral Agents. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Probing the Molecular Environment of Membrane Proteins In Vivo (1999)

The split-Ubiquitin (split-Ub) technique was used to map the molecular environment of a membrane protein in vivo. Cub, the C-terminal half of Ub, was attached to Sec63p, and Nub, the N-terminal half of Ub, was attached to a selection of differently localized proteins of the yeast Saccharomyces cerevisiae. The efficiency of the Nub and Cub reassembly to the quasi-native Ub reflects the proximity between Sec63-Cub and the Nub-labeled proteins. By using a modified Ura3p as the reporter that is released from Cub, the local concentration between Sec63-Cub-RUra3p and the different Nub-constructs could be translated into the growth rate of yeast cells on media lacking uracil. We show that Sec63p interacts with Sec62p and Sec61p in vivo. Ssh1p is more distant to Sec63p than its close sequence homologue Sec61p. Employing Nub- and Cub-labeled versions of Ste14p, an enzyme of the protein isoprenylation pathway, we conclude that Ste14p is a membrane protein of the ER. Using Sec63p as a reference, a gradient of local concentrations of different t- and v-SNARES could be visualized in the living cell. The RUra3p reporter should further allow the selection of new binding partners of Sec63p and the selection of molecules or cellular conditions that interfere with the binding between Sec63p and one of its known partners.
IBIHOP: Proper Privacy Preserving Mutual RFID Authentication (2013)

One of the concerns that comes with the use of RFID tags is that these respond to any query. This can be overcome by having mutual authentication between reader and tag. However, the ordering between the two authentication steps is crucial. In this paper, we formalise mutual RFID authentication: capturing the necessary coupling between tag authentication and reader authentication as well as the ordering between these authentication steps. We show that the reader needs to authenticate first to the yet unknown tag to 1) preserve the tag's privacy, 2) make it more resistant to side-channel analysis and 3) ensure that the end-user can observe the protocol's output. We propose a generic construction to transform existing private RFID authentication protocols into proper private RFID mutual authentication protocols. Finally, we design a very efficient wide-strong private RFID mutual authentication protocol that requires the tag to compute only three scalar-elliptic curve point multiplications. We also show how this new protocol can be implemented efficiently in hardware.
64-Channel WDM Transmitter based on Optical Fourier Transformation using a Portable Time Lens Assembly (2022)

We demonstrate 64-WDM-channel generation with 25-GHz spacing from a single SFP+ transceiver using a portable time lens optical processor. After transmission in a 50-km unamplified link, -39.1 dBm average received power sensitivity at BER=10 -3 is measured.
ChemInform Abstract: Tin(II) Chloride Dihydrate: A Mild and Efficient Reagent for Cleaving Acetals. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wave breaking signatures in noctilucent clouds (1993)

Results of a recent modeling study of gravity wave breaking in three dimensions by Andreassen et al. and Fritts et al. showed wave saturation to occur via a three‐dimensional instability oriented normal to the direction of wave propagation. The instability was found to occur at horizontal scales comparable to the depth of unstable regions within the wave field and to lead to substantial vertical displacements and tilting of isentropic surfaces. Because of strong similarities between the wave and instability structures in the simulation and the structure observed in noctilucent cloud layers near the summer mesopause, we have used these model results to compute the advective effects on cloud visibility and structure for a range of viewing angles and cloud layer widths. Our results show the gravity wave breaking signature to provide a plausible explanation of the observed structures and suggest that noctilucent cloud structures may be used in turn to infer qualitative properties of gravity wave scales, energy and momentum transports, and turbulence scales near the summer mesopause.
TGFβ Receptor I Conditional Knockout Mice Develop Spontaneous Squamous Cell Carcinoma (2007)

We generated a mouse model with a conditional deletion of TGF-beta signaling in the neurons by crossing TGF-beta receptor I (TbetaRI) floxed mice with neurofilament-H (NF-H) Cre mice. 35% of F1 conditional knockout (COKO) mice developed spontaneous squamous cell carcinomas (SCCs) in periorbital and/or perianal regions. Transplantation of these tumors into athymic nude mice resulted in 62% tumorigenicity. To determine whether evasion of the immune response plays any role in this tumorigenesis, we analyzed the expression levels of receptors for interleukin-13 (mIL-13R), a key negative regulator of tumor immunosurveillance, and found that 33% of COKO tumors expressed the IL-13R alpha2 chain. Primary cultures of the SCCs expressing IL-13R alpha2 were sensitive to the cytotoxic effect of IL-13R-directed cytotoxin treatment. This is the first demonstration that loss of TbetaRI can lead to spontaneous tumor formation. These mice can serve as a unique mouse model of SCC to evaluate the tumorigenicity and effect of anti-cancer therapeutics.
User Scored Evaluation of Non-Unique Explanations for Relational Graph Convolutional Network Link Prediction on Knowledge Graphs (2021)

Relational Graph Convolutional Networks (RGCNs) are commonly used on Knowledge Graphs (KGs) to perform black box link prediction. Several algorithms, or explanation methods, have been proposed to explain their predictions. Evaluating performance of explanation methods for link prediction is difficult without ground truth explanations. Furthermore, there can be multiple explanations for a given prediction in a KG. No dataset exists where observations have multiple ground truth explanations to compare against. Additionally, no standard scoring metrics exist to compare predicted explanations against multiple ground truth explanations. In this paper, we introduce a method, including a dataset (FrenchRoyalty-200k), to benchmark explanation methods on the task of link prediction on KGs, when there are multiple explanations to consider. We conduct a user experiment, where users score each possible ground truth explanation based on their understanding of the explanation. We propose the use of several scoring metrics, using relevance weights derived from user scores for each predicted explanation. Lastly, we benchmark this dataset on state-of-the-art explanation methods for link prediction using the proposed scoring metrics.
Security and Usability [Guest Editor's Introduction] (2007)

The five articles in this special issue address the need for usable security of our personal computers and how we can achieve that.
Synthesis of Potential Anticancer Agents. XX. 2-Fluoropurines2 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Potential Anticancer Agents. XX. 2-Fluoropurines2John A. Montgomery and Kathleen HewsonCite this: J. Am. Chem. Soc. 1960, 82, 2, 463–468Publication Date (Print):January 1, 1960Publication History Published online1 May 2002Published inissue 1 January 1960https://pubs.acs.org/doi/10.1021/ja01487a055https://doi.org/10.1021/ja01487a055research-articleACS PublicationsRequest reuse permissionsArticle Views446Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Need of Multidisciplinary Approaches and Engineering Tools for the Development and Implementation of the Smart City Paradigm (2018)

This paper is motivated by the concept that the successful, effective, and sustainable implementation of the smart city paradigm requires a close cooperation among researchers with different, complementary interests and, in most cases, a multidisciplinary approach. It first briefly discusses how such a multidisciplinary methodology, transversal to various disciplines such as architecture, computer science, civil engineering, electrical, electronic and telecommunication engineering, social science and behavioral science, etc., can be successfully employed for the development of suitable modeling tools and real solutions of such sociotechnical systems. Then, the paper presents some pilot projects accomplished by the authors within the framework of some major European Union (EU) and national research programs, also involving the Bologna municipality and some of the key players of the smart city industry. Each project, characterized by different and complementary approaches/modeling tools, is illustrated along with the relevant contextualization and the advancements with respect to the state of the art.
Synthesis, Thermodynamics, and Dynamics of Poly(4-tert-butylstyrene-b-methyl methacrylate) (2012)

A series of symmetric poly(4-tert-butylstyrene-block-methyl methacrylate) (PtBS-b-PMMA) diblock copolymers with varying molar masses and narrow molar mass distributions were prepared using sequential anionic polymerization. Order-to-disorder transition (ODT) temperatures were determined as a function of the overall degree of polymerization, N, using a combination of low-frequency dynamic mechanical spectroscopy (DMS) and variable temperature small-angle X-ray scattering (SAXS), leading to a mean-field expression for the segment–segment interaction parameter, χ = (41.2 ± 0.9)/T – (0.044 ± 0.002). This material is characterized by a larger value of χ, and much greater temperature sensitivity, than polystyrene-b-PMMA, providing access to tunable lamellar periods (pitch) down to 14 nm at technologically relevant temperatures. Nucleation and growth of lamellae, following cooling from the disordered state, was characterized by SAXS well above the glass transition temperature (Tg ≈ 130 °C) and extrapolated to lower processing temperatures based on polymer chain relaxation times extracted from time–temperature superposed DMS data. These results qualify PtBS-b-PMMA as an attractive candidate for development as a new lithographic material.
Successive integer-forcing and its sum-rate optimality (2013)

Integer-forcing receivers generalize traditional linear receivers for the multiple-input multiple-output channel by decoding integer-linear combinations of the transmitted streams, rather then the streams themselves. Previous works have shown that the additional degree of freedom in choosing the integer coefficients enables this receiver to approach the performance of maximum-likelihood decoding in various scenarios. Nonetheless, even for the optimal choice of integer coefficients, the additive noise at the equalizer's output is still correlated. In this work we study a variant of integer-forcing, termed successive integer-forcing, that exploits these noise correlations to improve performance. This scheme is the integer-forcing counterpart of successive interference cancellation for traditional linear receivers. Similarly to the latter, we show that successive integer-forcing is capacity achieving when it is possible to optimize the rate allocation to the different streams. In comparison to standard successive interference cancellation receivers, the successive integer-forcing receiver offers more possibilities for capacity achieving rate tuples, and in particular, ones that are more balanced.
Facteurs de variation de la composition en acides gras du lait de vache : peut-on les changer à la demande ? (2006)

National audience
MEMS tunable silicon Fabry-Perot cavity (2007)

In this paper we present an innovative tunable Fabry-Perot cavity micromachined in silicon. A short summary of the theoretical background of these filters is presented, followed by technical requirements for the design of the dielectric mirror composing the Fabry-Perot cavity and the cavity itself. Simulations and experimental data are demonstrated to be in good agreement. An in plane design is used to allow easy fiber alignment. The Fabry-Perot is tuned by an electrostatic comb drive actuator supported by a set of four springs to achieve a uniform modulation of the air gap of the filter. Only 15.4 V are required to tune the Fabry-Perot over 73nm bandwidth (covering more than the whole C-band) with a FWHM varying from 6 to 10nm. Transmission losses are -11dB.
5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA (2016)

In human and mouse stem cells and brain, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) can occur outside of CG dinucleotides. Using protein binding microarrays (PBMs) containing 60-mer DNA probes, we evaluated the effect of 5mC and 5hmC on one DNA strand on the double-stranded DNA binding of the mouse B-ZIP transcription factors (TFs) CREB1, ATF1, and JUND. 5mC inhibited binding of CREB1 to the canonical CRE half-site |GTCA but enhanced binding to the C/EBP half-site |GCAA. 5hmC inhibited binding of CREB1 to all 8-mers except TGAT|GCAA, where binding is enhanced. We observed similar DNA binding patterns with ATF1, a closely related B-ZIP domain. In contrast, both 5mC and 5hmC inhibited binding of JUND. These results identify new DNA sequences that are well-bound by CREB1 and ATF1 only when they contain 5mC or 5hmC. Analysis of two X-ray structures examines the consequences of 5mC and 5hmC on DNA binding by CREB and FOS|JUN.
Ionically conducting supports for oxidation catalysis (2015)

SSCI-VIDE+CARE+PVE
The role of the research simulator in the systems development of rotorcraft (1981)

Over the last 20 years, flight simulators have become widely accepted as training tools. Moreover, research simulators have been used extensively by the fixed-wind industry in the design, testing, and certification of new aircraft. The rotorcraft industry, however, has been slow to use man-in-the-loop simulation to solve its design problems, primarily because of the difficulty of modeling complex rotorcraft for realtime simulation and because of the need for a wide-angle visual system for low-level flight. A joint U.S. Army and NASA program has been initiated to provide this simulation capability for exploitation by both government and industry. This paper, a status report of that program, discusses the potential application of the research simulator to future rotorcraft systems design, development, product improvement evaluations, and safety analysis. (Author)
EVALUATION OF DRIVER INTERFACE FOR ADAPTIVE CRUISE CONTROL SYSTEM (1996)

This paper describes an on-going effort to study a driver interface for an Adaptive Cruise Control (ACC) system. The candidate interface consisted of visual display and auditory tones, and operating controls. The ACC used was based on a laser system and controlled the gap from a lead vehicle using throttle and down shift. A pilot study of a number of display candidates was performed to help develop guidelines for designing the visual interface. Evaluation of the current interface was conducted on a moving base driving simulator. A small scale field evaluation was done to validate those results. Thirty six subjects participated in the driving simulator evaluation, which was conducted in three parts. Three different locations were used to mount the visual LCD. This paper also describes some lessons learned and issues that perhaps require more testing. Results show a preference towards the location nearest the driver's normal line of sight.
Structures Related to Morphine. XIX.1 Benzomorphans from 3,4-Diethylpyridine (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures Related to Morphine. XIX.1 Benzomorphans from 3,4-DiethylpyridineJ. HARRISON AGER and EVERETTE L. MAYCite this: J. Org. Chem. 1962, 27, 1, 245–247Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/jo01048a059https://doi.org/10.1021/jo01048a059research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet. (1994)

To test the hypothesis that hepatic cholesteryl ester is involved in the regulation of apolipoprotein (apo) B secretion into plasma, apoB kinetic studies were performed in six control miniature pigs and in six pigs after a 21-day administration of the acyl coenzyme A:cholesterol acyltransferase (ACAT) inhibitor DuP 128 (2.2 mg.kg-1.d-1 i.v.). Pigs were fed low-fat, cholesterol-free diets. Total plasma cholesterol, triglyceride, very-low-density lipoprotein (VLDL) triglyceride, and low-density lipoprotein (LDL) cholesterol decreased 18%, 29%, 40%, and 26% respectively (P < .03). 131I-VLDL and 125I-LDL were injected simultaneously into each animal, and apoB kinetics were analyzed by using multi-compartmental analysis (SAAM30). VLDL apoB pool size decreased significantly by 60% (0.32 versus 0.84 mg/kg), which was due to a 65% reduction in the VLDL apoB production or secretion rate (1.03 versus 2.94 mg.kg-1.h-1). The fractional catabolic rate was unchanged. LDL apoB pool size decreased nonsignificantly by 18% (5.61 versus 6.90 mg/kg) due entirely to a 24% decrease in production rate (0.26 versus 0.34 mg.kg-1.h-1). At necropsy, hepatic microsomal ACAT activity decreased by 68% (0.28 versus 0.88 nmol.min-1.mg-1; P < .0002). Although an increase in hepatic free cholesterol leading to a decreased LDL receptor expression might be expected, this did not occur. The concentration of hepatic cholesterol and the LDL apoB fractional catabolic rate were unaffected by DuP 128. In addition, the concentration of hepatic triglyceride and the activity of diacylglycerol acyltransferase were not altered by DuP 128, indicating a lack of effect of DuP 128 on hepatic triglyceride metabolism. We conclude that inhibition of hepatic cholesteryl ester synthesis in vivo decreases apoB secretion into plasma.
On the Graph Fourier Transform for Directed Graphs (2017)

The analysis of signals defined over a graph is relevant in many applications, such as social and economic networks, big data or biological networks, and so on. A key tool for analyzing these signals is the so-called graph Fourier transform (GFT). Alternative definitions of GFT have been suggested in the literature, based on the eigen-decomposition of either the graph Laplacian or adjacency matrix. In this paper, we address the general case of directed graphs and we propose an alternative approach that builds the graph Fourier basis as the set of orthonormal vectors that minimize a continuous extension of the graph cut size, known as the Lovász extension. To cope with the nonconvexity of the problem, we propose two alternative iterative optimization methods, properly devised for handling orthogonality constraints. Finally, we extend the method to minimize a continuous relaxation of the balanced cut size. The formulated problem is again nonconvex, and we propose an efficient solution method based on an explicit-implicit gradient algorithm.
Data from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies (2023)

&lt;div&gt;Abstract&lt;p&gt;The bromodomain and extraterminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Pharmacological targeting of BRD4 bromodomains by small molecule inhibitors has proven to be an effective means to disrupt aberrant transcriptional programs critical for tumor growth and/or survival. Herein, we report AZD5153, a potent, selective, and orally available BET/BRD4 bromodomain inhibitor possessing a bivalent binding mode. Unlike previously described monovalent inhibitors, AZD5153 ligates two bromodomains in BRD4 simultaneously. The enhanced avidity afforded through bivalent binding translates into increased cellular and antitumor activity in preclinical hematologic tumor models. &lt;i&gt;In vivo&lt;/i&gt; administration of AZD5153 led to tumor stasis or regression in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B-cell lymphoma. The relationship between AZD5153 exposure and efficacy suggests that prolonged BRD4 target coverage is a primary efficacy driver. AZD5153 treatment markedly affects transcriptional programs of MYC, E2F, and mTOR. Of note, mTOR pathway modulation is associated with cell line sensitivity to AZD5153. Transcriptional modulation of MYC and HEXIM1 was confirmed in AZD5153-treated human whole blood, thus supporting their use as clinical pharmacodynamic biomarkers. This study establishes AZD5153 as a highly potent, orally available BET/BRD4 inhibitor and provides a rationale for clinical development in hematologic malignancies. &lt;i&gt;Mol Cancer Ther; 15(11); 2563–74. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;