gebhart/patrepeval huggingface dataset:
In Vitro Stimulation of Peripheral Blood Lymphocytes with Allogeneic Lymphocytes (Mixed Lymphocyte Culture, MLC) or Phytomitogens in Patients with Hashimoto's Thyroiditis (1978)

To investigate the role of peripheral blood lymphocytes in thyroid auto-immunity, the in vitro responsiveness to allogeneic lymphocytes (MLC) or phytomitogens was examined in the lymphocytes from patients with Hashimoto's thyroiditis. The MLC responses of 16 patients were compared with those of age- and sex-matched normal controls. All possible combinations between lymphocytes from the patients and controls were mixed in both one-way and two-way MLC. From the results of one-way MLC, the stimulatory capacity and responding capacity of lymphocytes from the patients and controls were calculated respectively as follows: : formula: (see text) To the same allogeneic stimulation of Nm (mitomycin-treated stimulating lymphocytes from controls), lymphocytes from the patients (H) exhibited a lower response (P greater than 0.05) than did those from the controls (compare (1) with (3)). Phytomitogen-response was simultaneously studied for residual cells of MLC. Lymphocytes from the patients showed a significantly decreased (P less than 0.01) response to phytohemagglutinin-p and concanavalin A in comparison with the response of normal lymphocytes. From these results, it was suggested that cell-mediated immunity in vivo was impaired in Hishimoto's thyroiditis.
Copper catalyzed oxidative ortho-C–H benzoxylation of 2-phenylpyridines with benzyl alcohols and benzyl amines as benzoxylation sources (2014)

A simple and efficient protocol for the oxidative ortho benzoxylation of 2-phenylpyridines with benzyl alcohols and benzyl amines via C-H bond activation has been developed. The present protocol uses benzyl alcohol and benzyl amine as inexpensive and easily available starting materials to afford benzoxylation products in moderate to good yields in the presence of the Cu/TBHP catalytic system.
Early behavioral screening for antidepressants and anxiolytics (2006)

Abstract Early preclinical behavioral testing is an essential stage during the development of substances with potential antidepressant and/or anxiolytic activity. With the growing cost of drug development, optimal research strategies are needed to detect potential new treatments with high efficacy and minimal side effects and to confirm in vitro pharmacological studies. In the following article, we present simple rodent tests used for early behavioral testing for antidepressant‐like and anxiolytic‐like activity. Unpublished results from our laboratory are discussed with reference to published data to illustrate the predictive validity of several behavioral screening tests. Drug Dev. Res. 67:729–742, 2006. © 2006 Wiley‐Liss, Inc.
Thermal performance of multilayer insulations (1974)

Experimental and analytical studies were conducted in order to extend previous knowledge of the thermal performance and gas evacuation characteristics of three selected multilayer insulation (MLI) composites. Flat plate calorimeter heat flux measurements were obtained for 20- and 80- shield specimens using three representative layer densities over boundary temperatures ranging from 39 K (70 R) to 389 K (700 R). Laboratory gas evacuation tests were performed on representative specimens of each MLI composite after initially purging them with helium, nitrogen, or argon gases. In these tests, the specimens were maintained at temperatures between 128 K (230 R) and 300 K (540 R). Based on the results of the laboratory-scale tests, a composite MLI system consisting of 112 unperforated, double-aluminized Mylar reflective shields and 113 water preconditioned silk net spacer pairs was fabricated and installed on a 1.22-m-(4-ft-) diameter calorimeter tank.
Surgical and Transcatheter Mitral Valve Replacement in Mitral Annular Calcification: A Systematic Review (2021)

Mitral annular calcification with mitral valve disease is a challenging problem that could necessitate surgical mitral valve replacement (SMVR). Transcatheter mitral valve replacement (TMVR) is emerging as a feasible alternative in high-risk patients with appropriate anatomy. PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched from inception to December 25, 2019 for studies discussing SMVR or TMVR in patients with mitral annular calcification; 27 of 1539 articles were selected for final review. TMVR was used in 15 studies. Relevant data were available on 82 patients who underwent hybrid transatrial TMVR, and 354 patients who underwent transapical or transseptal TMVR. Outcomes on SMVR were generally reported as small case series (447 patients from 11 studies); however, 1 large study recently reported outcomes in 9551 patients. Patients who underwent TMVR had a shorter median follow-up of 9 to 12 months (range, in-hospital‒19 months) compared with patients with SMVR (54 months; range, in-hospital‒120 months). Overall, those undergoing TMVR were older and had higher Society of Thoracic Surgeons risk scores. SMVR showed a wide range of early (0%-27%; median 6.3%) and long-term mortality (0%-65%; median at 1 year, 15.8%; 5 years, 38.8%, 10 years, 62.4%). The median in-hospital, 30-day, and 1-year mortality rates were 16.7%, 22.7%, and 43%, respectively, for transseptal/transapical TMVR, and 9.5%, 20.0%, and 40%, respectively, for transatrial TMVR. Mitral annular calcification is a complex disease and TMVR, with a versatile option of transatrial approach in patients with challenging anatomy, offers a promising alternative to SMVR in high-risk patients. However, further studies are needed to improve technology, patient selection, operative expertise, and long-term outcomes.
Keeping an open heart in hell (2011)

Abuse is not just due to systems – it is a failure of individual conscience, says Stephen Wright
Java™ how to program, seventh edition (2006)

The Deitels' groundbreaking How to Program series offers unparalleled breadth and depth of object-oriented programming concepts and intermediate-level topics for further study. This survey of Java programming contains an extensive OOD/UML 2 case study on developing an automated teller machine. The Seventh Edition has been extensively fine-tuned and is completely up-to-date with Sun Microsystems, Inc.'s latest Java releasei¾Java Standard Edition (Java SE) 6.
ChemInform Abstract: An Improved Synthetic Protocol and Plausible Mechanism in Forming Acetylpyridines from 2,6‐Dicarbethoxypyridine. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Key distribution without individual trusted authentification servers (2002)

Some recent research on key distribution systems has focussed on analysing trust in authentication servers, and constructing key distribution protocols which operate using a number of authentication servers, which have the property that a minority of them may be untrustworthy. This paper proposes two key distribution protocols with multiple authentication servers using a cross checksum scheme. Both protocol are based on the use of symmetric encryption for verifying the origin and integrity of messages. In these protocols it is not necessary for clients to trust an individual authentication server. A minority of malicious and colluding servers cannot compromise security and can be detected. The first 'parallel' protocol can prevent a minority of servers disrupting the service. The second 'cascade' protocol has to work with other security mechanisms in order to prevent a server breaking the procedure by refusing to cooperate. As compared with other proposed protocols with similar properties these two protocols require less exchanged messages.
Neural Mechanisms Underlying Breathing Complexity (2013)

Breathing is maintained and controlled by a network of automatic neurons in the brainstem that generate respiratory rhythm and receive regulatory inputs. Breathing complexity therefore arises from respiratory central pattern generators modulated by peripheral and supra-spinal inputs. Very little is known on the brainstem neural substrates underlying breathing complexity in humans. We used both experimental and theoretical approaches to decipher these mechanisms in healthy humans and patients with chronic obstructive pulmonary disease (COPD). COPD is the most frequent chronic lung disease in the general population mainly due to tobacco smoke. In patients, airflow obstruction associated with hyperinflation and respiratory muscles weakness are key factors contributing to load-capacity imbalance and hence increased respiratory drive. Unexpectedly, we found that the patients breathed with a higher level of complexity during inspiration and expiration than controls. Using functional magnetic resonance imaging (fMRI), we scanned the brain of the participants to analyze the activity of two small regions involved in respiratory rhythmogenesis, the rostral ventro-lateral (VL) medulla (pre-Bötzinger complex) and the caudal VL pons (parafacial group). fMRI revealed in controls higher activity of the VL medulla suggesting active inspiration, while in patients higher activity of the VL pons suggesting active expiration. COPD patients reactivate the parafacial to sustain ventilation. These findings may be involved in the onset of respiratory failure when the neural network becomes overwhelmed by respiratory overload We show that central neural activity correlates with airflow complexity in healthy subjects and COPD patients, at rest and during inspiratory loading. We finally used a theoretical approach of respiratory rhythmogenesis that reproduces the kernel activity of neurons involved in the automatic breathing. The model reveals how a chaotic activity in neurons can contribute to chaos in airflow and reproduces key experimental fMRI findings.
Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1 Is a Molecular Determinant of the Cardiac Pacemaker Current I f (2001)

The pacemaker current I(f) of the sinoatrial node (SAN) is a major determinant of cardiac diastolic depolarization and plays a key role in controlling heart rate and its modulation by neurotransmitters. Substantial expression of two different mRNAs (HCN4, HCN1) of the family of pacemaker channels (HCN) is found in rabbit SAN, suggesting that the native channels may be formed by different isoforms. Here we report the cloning and heterologous expression of HCN1 from rabbit SAN and its specific localization in pacemaker myocytes. rbHCN1 is an 822-amino acid protein that, in human embryonic kidney 293 cells, displayed electrophysiological properties similar to those of I(f), suggesting that HCN1 can form a pacemaker channel. The presence of HCN1 in the SAN myocytes but not in nearby heart regions, and the electrophysiological properties of the channels formed by it, suggest that HCN1 plays a central and specific role in the formation of SAN pacemaker currents.
On the Variety of Invariant Subspaces of a Finite-Dimensional Linear Operator (1982)

If V is a finite-dimensional vector space over R or C and A E Hom( V), the set SA(k) of k-dimensional A-invariant subspaces is a compact subvariety of the Grassmann manifold Gk(V), but it need not be a Schubert variety.We study the topology of SA(k).We reduce to the case where A is nilpotent.In this case we prove that SA(k) is connected but need not be a manifold.However, the subset of SA(k) consisting of those subspaces with a fixed cyclic structure is a regular submanifold of Gk(V).
Intra-Aortic Balloon Pump on In-Hospital Outcomes of Cardiogenic Shock: Findings from a Nationwide Registry, China (2021)

In this nationwide registry of CS patients, IABP was not noted with improved survival but increased healthcare consumption. However, IABP appears protective in those with myocarditis or who failed to receive early PCI.
Liquid Transport due to Light Scattering (2007)

Using experiments and theory, we show that light scattering by inhomogeneities in the index of refraction of a fluid can drive a large-scale flow. The experiment uses a near-critical, phase-separated liquid, which experiences large fluctuations in its index of refraction. A laser beam traversing the liquid produces a interface deformation on the scale of the experimental setup and can cause a liquid jet to form. We demonstrate that the deformation is produced by a scattering-induced flow by obtaining good agreements between the measured deformations and those calculated assuming this mechanism.
Analytical and Clinical Sample Performance Characteristics of the Onclarity Assay for the Detection of Human Papillomavirus (2020)

The objective of this study was to determine the result reproducibility and performance of the BD Onclarity human papillomavirus (HPV) assay (Onclarity) on the BD Viper LT platform using both contrived and clinical specimens. Reproducibility was assessed in BD SurePath liquid-based cytology (LBC) medium (SurePath) using contrived panels (HPV genotype 16 [HPV16] positive, HPV18 positive, or HPV45 positive) or clinical specimens (HPV16, -18, -31, -33/58, -45, or -52 positive or HPV negative). In addition, specimens from 3,879 individuals from the Onclarity trial were aliquoted prior to or following cytology processing and tested for HPV. Finally, specimens were collected using either the Cervex-Brush or Cytobrush (or Cytobrush/spatula) for comparison of HPV results. Contrived specimens showed >95% concordance with the expected results, and pooled clinical specimens had standard deviations and coefficients of variation ranging from 0.87 to 1.86 and 2.9% to 5.6%, respectively. For precytology and postcytology aliquot analyses, specimens showed >98.0% overall agreement and mean differences in cycle threshold (<i>C<sub>T</sub></i> ) scores for HPV ranging from -0.07 to 0.31. Positivity rates were close between the Cervex-Brush and Cytobrush/spatula for all age groups tested. Onclarity results are reproducible and reliable, regardless of sample collection before or after cytology aliquoting. Onclarity performs well regardless of the method of specimen collection (Cervex-Brush or Cytobrush/spatula) for cervical cancer screening.
Examining Teacher Perspectives on Computational Thinking in K-12 Classrooms (2020)

This paper examines K-12 teacher perspectives on the promise and challenges of computer science (CS) and computational thinking (CT) education for all students across three states and three school districts-one rural, one suburban, and one urban. Through a series of teacher survey and focus groups, this exploratory research presents the perspectives of K-12 teachers across three distinct vantage points: First, to what degree do these teachers see a clear value as to why CS and CT matter to their students' learning? Second (if the pathway is deemed valuable) who, in their estimates, are the crucial players to help develop a coherent CS/ CT K-12 pathway and what is their capacity? Third, how can such a prospective pathway be practically implemented? These elements of why, who, and how are essential to wider questions around equity of student access to high quality computing, and with this paper, they come from the perspectives of teachers-a group too often left out of early discussions around K-12 curricular design. Discussion section points to how these preliminary surveys and focus groups with teachers offer an early predictor in terms of how each district develops its own K-12 computing pathway, with the expectation that such focus groups offer a powerful research/ evaluation protocol that can be repeated annually among districts to gauge to what extent teachers' hope (and concerns) about comprehensive K-12 computing pathways are warranted.
[Association of autoimmune chronic active hepatitis and acquired erythroblastopenia cured by cyclophosphamide]. (1986)

To the best of our knowledge this is the reported first case of the successive occurrence in the same patient of chronic active hepatitis and acquired pure red cell aplasia, both probably of autoimmune origin. The diagnosis of autoimmune hepatitis was based on the presence of characteristic lesions at the examination of the liver biopsy specimen, high titer of anti-smooth muscle antibodies in the serum, and remission obtained by steroid therapy. Erythroid aplasia, which appeared during the course of this treatment, was revealed by a regenerative anemia (4.4 g Hb/100 ml) and proved by bone marrow aspiration and biopsy. In vitro bone marrow culture was normal, suggesting the in vivo presence of an inhibitor of erythroblastic differentiation. Red cell aplasia was cured by cyclophosphamide (100 mg/day during 56 days). No recurrence was noted until the death of the patient, which occurred one year later, due to hepatic cholangiocarcinoma. Action of cyclophosphamide on the pure red cell aplasia suggested the immune origin of this disease. The liver and the bone marrow erythroid lineage have probably been the successive targets of immunologic dyscrasia.
Replacement of NCTC 4175, the Current Type Strain of Proteus vulgaris, with ATCC 29905: Request for an Opinion (1995)

The current type strain of Proteus vulgaris, NCTC 4175 (= ATCC 13315), differs substantially from typical strains of this species both biochemically and chemotaxonomically. DNA relatedness studies revealed that strains previously classified as P. vulgaris belong to six genomospecies. One of these genomospecies contains strains that are negative in indole, salicin, and esculin reactions (biogroup 1) and has been named Proteus penneri. A second genomospecies, which is most frequently isolated from human urine, contains typical P. vulgaris strains that are positive in indole, salicin, and esculin reactions (biogroup 2). The members of the remaining four genomospecies are indole positive and negative in salicin and esculin reactions (biogroup 3). Of 36 biogroup 3 strains studied, only strain NCTC 4175T (T = type strain) and one other strain, CDC 1732-80, belong to genomospecies 3. To retain NCTC 4175 as the type strain of P. vulgaris would restrict this species to these two strains, whose origins are unknown. This would mean that hundreds of strains for which the description of P. vulgaris was written and which have been representatives of this species for the past 50 years would have to be renamed as members of a new species. To prevent this confusion, we request that biogroup 2 reference strain ATCC 29905 (= CDC PR1) replace NCTC 4175 as the type strain of P. vulgaris.
DirtNet: Visual Dirt Detection for Autonomous Cleaning Robots (2020)

Visual dirt detection is becoming an important capability of modern professional cleaning robots both for optimizing their wet cleaning results and for facilitating demand-oriented daily vacuum cleaning. This paper presents a robust, fast, and reliable dirt and office item detection system for these tasks based on an adapted YOLOv3 framework. Its superiority over state-of-the-art dirt detection systems is demonstrated in several experiments. The paper furthermore features a dataset generator for creating any number of realistic training images from a small set of real scene, dirt, and object examples.
High-efficiency trichromatic LED backlight for mobile LCDs (2006)

Trichromatic LED backlights render higher color gamut and panel transmittance to the liquid crystal displays (LCDs) than yellow phosphor-converted white LED backlights can possibly do at their best. In realization, however, several technical challenges arise, such as color mixing, minimizing the total number of chips, and maintaining the color balance. We designed and demonstrated a backlight unit for 2.2 inch TFT LCD using two RGB 3-chip LEDs to assess the feasibility and the technical hurdles to overcome. The average brightness of the backlight is 2509cd/m<sup>2</sup> at the input power of 200mW. The power efficiency is lower than but comparable to commercially available white LED backlights. The color gamut of the LC panel is increased from 53% to 78% when its conventional white LED backlight is replaced by the trichromatic LED backlight. Panel transmittance is expected to be enhanced as well by about 8%. The ambient temperature change was found to be the most significant cause of the color shift of the trichromatic LED backlight. The forward bias voltage can be used in the feedback, since it changes linearly with temperature.
NSP4 Enterotoxin of Rotavirus Induces Paracellular Leakage in Polarized Epithelial Cells (2001)

The nonstructural NSP4 protein of rotavirus has been described as the first viral enterotoxin. In this study we have examined the effect of NSP4 on polarized epithelial cells (MDCK-1) grown on permeable filters. Apical but not basolateral administration of NSP4 was found to cause a reduction in the transepithelial electrical resistance, redistribution of filamentous actin, and an increase in paracellular passage of fluorescein isothiocyanate-dextran. Significant effects on transepithelial electrical resistance were noted after a 20- to 30-h incubation with 1 nmol of NSP4. Most surprisingly, the epithelium recovered its original integrity and electrical resistance upon removal of NSP4. Preincubation of nonconfluent MDCK-1 cells with NSP4 prevented not only development of a permeability barrier but also lateral targeting of the tight-junction-associated Zonula Occludens-1 (ZO-1) protein. Taken together, these data indicate new and specific effects of NSP4 on tight-junction biogenesis and show a novel effect of NSP4 on polarized epithelia.
Supplementary Data from Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms (2023)

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Proteomic profiling of animal models mimicking skeletal muscle disorders (2007)

Over the last few decades of biomedical research, animal models of neuromuscular diseases have been widely used for determining pathological mechanisms and for testing new therapeutic strategies. With the emergence of high-throughput proteomics technology, the identification of novel protein factors involved in disease processes has been decisively improved. This review outlines the usefulness of the proteomic profiling of animal disease models for the discovery of new reliable biomarkers, for the optimization of diagnostic procedures and the development of new treatment options for skeletal muscle disorders. Since inbred animal strains show genetically much less interindividual differences as compared to human patients, considerably lower experimental repeats are capable of producing meaningful proteomic data. Thus, animal model proteomics can be conveniently employed for both studying basic mechanisms of molecular pathogenesis and the effects of drugs, genetic modifications or cell-based therapies on disease progression. Based on the results from comparative animal proteomics, a more informed decision on the design of clinical proteomics studies could be reached. Since no one animal model represents a perfect pathobiochemical replica of all of the symptoms seen in complex human disorders, the proteomic screening of novel animal models can also be employed for swift and enhanced protein biochemical phenotyping.