gebhart/patrepeval huggingface dataset:
Yes-associated Protein and p53-binding Protein-2 Interact through Their WW and SH3 Domains (2001)

To understand the role of the Yes-associated protein (YAP), binding partners of its WW1 domain were isolated by a yeast two-hybrid screen. One of the interacting proteins was identified as p53-binding protein-2 (p53BP-2). YAP and p53BP-2 interacted in vitro and in vivo using their WW1 and SH3 domains, respectively. The YAP WW1 domain bound to the YPPPPY motif of p53BP-2, whereas the p53BP-2 SH3 domain interacted with the VPMRLR sequence of YAP, which is different from other known SH3 domain-binding motifs. By mutagenesis, we showed that this unusual SH3 domain interaction was due to the presence of three consecutive tryptophans located within the betaC strand of the SH3 domain. A point mutation within this triplet, W976R, restored the binding selectivity to the general consensus sequence for SH3 domains, the PXXP motif. A constitutively active form of c-Yes was observed to decrease the binding affinity between YAP and p53BP-2 using chloramphenicol acetyltransferase/enzyme-linked immunosorbent assay, whereas the overexpression of c-Yes did not modify this interaction. Since overexpression of an activated form of c-Yes resulted in tyrosine phosphorylation of p53BP-2, we propose that the p53BP-2 phosphorylation, possibly in the WW1 domain-binding motif, might negatively regulate the YAP.p53BP-2 complex.
Development of Laser Water Level Measuring System without Cooperative Target (2012)

A new water level measuring system, using laser rangefinder sensor with phase method as laser water level sensor without cooperative target is presented. The laboratory and field experiments have been done to confirm the application field and measuring accuracy of system. The results show that the measuring accuracy could reach to ±1.5 mm in calm water in case that water turbidity value is greater than 300 NTU. Furthermore, the measuring accuracy can reach to ±3mm for the measuring period taking 5 minute in case of the water surface sloshing. The maximum measuring distance of system could reach to 12m.
Coating generation: Vaporization of particles in plasma spraying and splat formation (1996)

Abstract
ChemInform Abstract: Advances in the Development of Methods for the Synthesis of Second‐Generation HMG‐CoA Reductase Inhibitors [Fluvastatin Sodium (Lescol), Rosuvastatin Calcium (Crestor), Pitavastatin Calcium (Livalo)] (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Prevalence of Hyperoxaluria in Idiopathic Calcium Oxalate Kidney Stone Disease (1983)

Urinary excretion of oxalate, calcium and urate has been investigated in 88 patients affected by idiopathic calcium oxalate stone disease and in 20 normal subjects. Of these ions, only oxalate was found significantly higher in stone formers. Defining hyperoxaluria as urinary oxalate excretion greater than 2 SD above normal, 50% of stone-forming people were found to be hyperoxaluric. When stone formers were classified in normo- and hyperoxaluric, the prevalence of hypercalciuria, hyperuricuria, family history of stone disease and recurrencies in stone formation was the same in both groups. It is concluded that hyperoxaluria is a frequent finding in idiopathic calcium oxalate renal stone disease.
P015 : Changes in serum IgE level according to age in patients with atopic dermatitis in Korea (2018)

Background: Atopic dermatitis is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology. The clinical feature of atopic dermatitis varies depending on the age of the patient. Serum IgE level is useful biomarker to appreciate the sensitization profile of patient with allergic diseases.
Objectives: We investigated to identify the changes in serum IgE level according to age in patients with atopic dermatitis in Korea.
Methods: We included 779 patients who were diagnosed with atopic dermatitis according to the criteria of Hanifin & Rajka and tested serum IgE level registered Department of Dermatology, Nowon Eulji Medical Center between January 2013 and May 2018. We defined serum IgE level under 200 kU/L indicate intrinsic atopic dermatitis and 200kU/L or/and above indicate extrinsic atopic dermatitis.
Results: The patients with intrinsic atopic dermatitis were more common until early childhood (2-6 years). From childhood, percentage of extrinsic atopic dermatitis began to increase to 51.3%. In adolescent, patients with extrinsic atopic dermatitis were twice as many as those with intrinsic atopic dermatitis and 1.22 times more in young adult. From adult, the proportion of patient with intrinsic atopic dermatitis increased again.
Conclusion: We suggest that there might be some associations between changes of clinical feature of atopic dermatitis and changes of serum IgE level according to age.
Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum (2016)

Cytoglobosins H (<b>1</b>) and I (<b>2</b>), together with seven known cytochalasan alkaloids (<b>3</b>-<b>9</b>), were isolated from the deep-sea-derived fungus <i>Chaetomium globosum</i>. The structures of new compounds <b>1</b> and <b>2</b> were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound <b>6</b> showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC<sub>50</sub> values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound <b>6</b> inhibited the growth of LNCaP cells by inducing apoptosis.
Discrete plane‐wave decomposition by least‐mean‐error squares method (1991)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1991Discrete plane‐wave decomposition by least‐mean‐error squares methodAuthors: Orhan YilmazM. Turhan TanerOrhan YilmazSeismic Research Corp. and Univ. of Houston Seismic Acoustic Labs and M. Turhan TanerSeismic Research Corp. and Rice Univ.https://doi.org/10.1190/1.1889013 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1889013FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1991ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1991 Pages: 1646 publication data© 1991 Copyright © 1991 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Orhan Yilmaz and M. Turhan Taner, (1991), "Discrete plane‐wave decomposition by least‐mean‐error squares method," SEG Technical Program Expanded Abstracts : 1484-1487. https://doi.org/10.1190/1.1889013 Plain-Language Summary PDF DownloadLoading ...
SOME SOURCES OR PARALLELS TO POEMS BY TED HUGHES (1968)

SOME SOURCES OR PARALLELS TO POEMS BY TED HUGHES Get access C. J. RAWSON C. J. RAWSON University of Warwick Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 15, Issue 2, February 1968, Pages 62–63, https://doi.org/10.1093/nq/15-2-62 Published: 01 February 1968
Prognostics and Health Management Software for Gas Turbine Engine Bearings (2007)

Based on the results of a successful Phase I and II SBIR program performed by Impact Technologies, a suite of Prognostics and Health Management (PHM) algorithms have been developed for detecting incipient faults in the critical bearings associated with aircraft gas turbine engines. The component-level prognostic approach is presented that utilizes available sensor information from vibration transducers, along with material-level component fatigue models to calculate remaining useful life for the engine’s critical components. Specifically, correlation between the sensed data and fatigue-based damage accumulation models were developed to provide remaining useful life assessments for life limited components. The combination of health monitoring data and model-based techniques provides a unique and knowledge rich capability that can be utilized throughout the bearings’s entire life, using model-based estimates when no diagnostic indicators are present and using the monitored vibration features at later stages when incipient failure indications are detectable, thus reducing the uncertainty in model-based predictions. A description and specific implementation of this prognosis approach with application to high speed bearings is illustrated herein, using gas turbine engine and bearing test rig data as validation for the methods.
Gravitational Test beyond the First Post-Newtonian Order with the Shadow of the M87 Black Hole (2020)

The 2017 Event Horizon Telescope (EHT) observations of the central source in M87 have led to the first measurement of the size of a black-hole shadow. This observation offers a new and clean gravitational test of the black-hole metric in the strong-field regime. We show analytically that spacetimes that deviate from the Kerr metric but satisfy weak-field tests can lead to large deviations in the predicted black-hole shadows that are inconsistent with even the current EHT measurements. We use numerical calculations of regular, parametric, non-Kerr metrics to identify the common characteristic among these different parametrizations that control the predicted shadow size. We show that the shadow-size measurements place significant constraints on deviation parameters that control the second post-Newtonian and higher orders of each metric and are, therefore, inaccessible to weak-field tests. The new constraints are complementary to those imposed by observations of gravitational waves from stellar-mass sources.
Camera localization and building reconstruction from single monocular images (2008)

This paper presents a new method for reconstructing rectilinear buildings from single images under the assumption of flat terrain. An intuition of the method is that, given an image composed of rectilinear buildings, the 3D buildings can be geometrically reconstructed by using the image only. The recovery algorithm is formulated in terms of two objective functions which are based on the equivalence between the vector normal to the interpretation plane in the image space and the vector normal to the rotated interpretation plane in the object space. These objective functions are minimized with respect to the camera pose, the building dimensions, locations and orientations to obtain estimates for the structure of the scene. The method potentially provides a solution for large-scale urban modelling using aerial images, and can be easily extended to deal with piecewise planar objects in a more general situation.
Locating Facial Features with Active Shape Models (2007)

This dissertation focuses on the problem of locating features in frontal views of upright human faces. The dissertation starts with the Active Shape Model of Cootes et al. [20] and extends it with the following techniques: (1) selectively using twoinstead of one-dimensional landmark profiles (2) stacking two Active Shape Models in series (3) extending the set of landmarks (4) trimming covariance matrices by setting most entries to zero (5) using other modifications such as adding noise to the training set. The resulting feature locater is shown to compare favorably with previously published methods. Declaration I, Stephen Milborrow, declare that this dissertation is my own work except where otherwise stated. It is being submitted for the degree of Master of Science in Engineering at the University of Cape Town and it has not been submitted before for any degree or examination at any other university. Signature of Author August 2007 Petaluma CA To my parents, Geoff and Libby.
Stabilizing GANs with Octave Convolutions. (2019)

In this preliminary report, we present a simple but very effective technique to stabilize the training of CNN based GANs. Motivated by recently published methods using frequency decomposition of convolutions (e.g. Octave Convolutions), we propose a novel convolution scheme to stabilize the training and reduce the likelihood of a mode collapse. The basic idea of our approach is to split convolutional filters into additive high and low frequency parts, while shifting weight updates from low to high during the training. Intuitively, this method forces GANs to learn low frequency coarse image structures before descending into fine (high frequency) details. Our approach is orthogonal and complementary to existing stabilization methods and can simply plugged into any CNN based GAN architecture. First experiments on the CelebA dataset show the effectiveness of the proposed method.
Ba 3 ZnTa 2−x Nb x O 9 and Ba 3 MgTa 2−x Nb x O 9 (0≤x ≤1): synthesis, structure and dielectric properties (2002)

Oxides belonging to the families Ba 3 ZnTa 2−x Nb x O 9 and Ba 3 MgTa 2−x Nb x O 9 were synthesized by the solid state reaction route. Sintering temperatures of 1300°C led to oxides with disordered (cubic) perovskite structure. However, on sintering at 1425°C hexagonally ordered structures were obtained for Ba 3 MgTa 2−x Nb x O 9 over the entire range (0≤x≤1) of composition, while for Ba 3 ZnTa 2−x Nb x O 9 the ordered structure exists in a limited range (0≤x≤0.5). The dielectric constant is close to 30 for the Ba 3 ZnTa 2−x Nb x O 9 family of oxides while the analogues have lower dielectric constant of ~18 in the range 50 Hz to 500 kHz. At microwave frequencies (5-7 GHz) dielectric constant increases with increase in niobium concentration (22-26) for Ba 3 ZnTa 2−x Nb x O 9 ; for Ba 3 MgTa 2−x Nb x O 9 it varies between 12 and 14. The Zn compounds have much higher quality factors and lower temperature coefficient of resonant frequency compared to the Mg analogues.
Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor (2013)

Understanding the molecular basis of drug action can facilitate development of more potent and selective drugs. Here, we explore the molecular basis for action of a unique small molecule ligand that is a type 1 cholecystokinin (CCK) receptor agonist and type 2 CCK receptor antagonist, GI181771X. We characterize its binding utilizing structurally related radioiodinated ligands selective for CCK receptor subtypes that utilize the same allosteric ligand-binding pocket, using wild-type receptors and chimeric constructs exchanging the distinct residues lining this pocket. Intracellular calcium assays were performed to determine biological activity. Molecular models for docking small molecule agonists to the type 1 CCK receptor were developed using a ligand-guided refinement approach. The optimal model was distinct from the previous antagonist model for the same receptor and was mechanistically consistent with the current mutagenesis data. This study revealed a key role for Leu(7.39) that was predicted to interact with the isopropyl group in the N1 position of the benzodiazepine that acts as a "trigger" for biological activity. The molecular model was predictive of binding of other small molecule agonists, effectively distinguishing these from 1065 approved drug decoys with an area under curve value of 99%. The model also selectively enriched for agonist compounds, with 130 agonists identified by ROC analysis when seeded in 2175 non-agonist ligands of the type 1 CCK receptor (area under curve 78%). Benzodiazepine agonists in this series docked in consistent pose within this pocket, with a key role played by Leu(7.39), whereas the role of this residue was less clear for chemically distinct agonists.
Specific dynamic and noninvasive labeling of pancreatic β cells in reporter mice (2005)

Noninvasive detection of differentiated cells is increasingly demanded for accurate and reliable assessments of both in vitro and in vivo experimental systems. Here we present an efficient, innovative approach for imaging the beta cells of the pancreatic islets of Langerhans. The main physiologic function of beta cells is glucose-stimulated insulin secretion. This function is facilitated through the synthesis and storage of insulin in secretory vesicles of beta cells, which then release their contents when beta cells are exposed to hyperglycemic conditions. To visualize beta cells in vivo in the mouse, we used targeted mutagenesis techniques to construct a modified insulin II (InsII) gene allele, InsII(EGFP), that expresses a proinsulin-EGFP (enhanced green fluorescent protein) fusion peptide. The EGFP portion of this fusion is entirely within the C-peptide portion of the proinsulin peptide. This fusion protein is processed in beta cells to insulin and EGFP-tagged C peptide, which are stored together in cytoplasmic secretory vesicles. The large amount of vesicular EGFP-tagged C peptide is evident as a characteristic robust and specific fluorescence pattern in the beta cells of InsII(EGFP) mice. This innovative method of visualizing beta cells will be a useful tool in the study of both beta cell physiology and the development of the endocrine cells of the pancreas.
Author response: Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1 (2013)

Obesity is a complex metabolic disorder that is caused by increased food intake and decreased expenditure of energy. Obesity also increases the risk of developing type 2 diabetes, heart disease, stroke, arthritis, and certain cancers. There is considerable evidence to suggest that adipose tissue becomes less sensitive to catecholamines such as adrenaline in states of obesity, and that this reduced sensitivity in turn reduces energy expenditure. However, the details of this process are not fully understood. It is well established that obesity generates a state of chronic, low-grade inflammation in liver and adipose tissue, accompanied by the secretion of signaling proteins that prevent fat cells from responding to insulin, which leads to type 2 diabetes. Activation of the NFκB pathway is thought to have a central role in causing this inflammation. Now Mowers et al. have investigated whether inflammation caused by activation of the NFκB pathway also has a role in producing catecholamine resistance in fat cells. Obesity-dependent activation of the NFκB pathway increases the levels of a pair of enzymes, IKKε and TBK1. Mowers et al. found that elevated levels of these two enzymes reduced the ability of certain receptors (called β-adrenergic receptors) in the fat cells of obese mice to respond to catecholamines. High levels of the two enzymes also resulted in lower levels of a second messenger molecule called cAMP, which increases energy expenditure by elevating fat burning. However, treating the fat cells with drugs that interfere with the two enzymes restored sensitivity to catecholamine, allowing the fat cells to burn energy. Mowers et al. also treated obese mice with amlexanox, a drug that inhibits these enzymes, and found that this treatment made the mice sensitive to a synthetic catecholamine that triggered the release of energy from fat. Mowers et al. suggest, therefore, that IKKε and TBK1 respond to inflammation in the body by reducing catecholamine signaling, thus preventing energy expenditure. Drugs targeting these enzymes may be useful for treating conditions like obesity or type 2 diabetes.
Beneficial effect of very thin active layer on the performance of microcrystalline silicon TFT (2012)

International audience
Une chanson de… (2012)

Y a-t-il quelque différence entre, disons, « une chanson de Félix Leclerc » et « une chanson de Renée Claude » ? Je ne parle pas, ici, de qualité (ou de popularité), mais de syntaxe ! À première vue, aucune différence. C’est la même structure : une chanson de X, de Y. Encore faut-il savoir qui est Leclerc et qui est Claude. Quand on le sait, on sait, entre autres choses, que le premier est auteur-compositeur-interprète (et reçoit des droits en tant qu’auteur et en tant que compositeur), que l...
Introduction of Neodymium Ion(III) into Monomer and Polymer through Complexation with Phosphoric Acid Ester Used as a Ligand. (1997)

ネオジムイオン (III) の有機雰囲気中への可溶化のための配位子としてリン酸メタクリロイルオキシエチル (PMOE) を用いることによって, 高濃度のNd3+イオンをメチルメタクリレート (MMA), ポリ (メチルメタクリレート) (PMMA) 中に可溶化できた. PMOEはリン酸基とメタクリロイル基を有しているが, これらによる多座配位によって, コンパクトで低分子量の錯体が形成され, 可溶化できたと考えられる. 得られたPMMAは透明度が高く, またNd3+イオンの吸収特性を示した.
An object position and orientation IC with embedded imager (1991)

A CMOS VLSI chip that determines the position and orientation of an object against a dark background is described. The chip operates in a continuous-time analog fashion, with a response time as short as 200 mu s and power consumption under 50 mW. A self-contained phototransistor array acquires the image directly, and the output is a set of eight currents from which the position and orientation can be found. The output can be sampled at up to 5000 frames/s, and there is a greatly reduced analog-digital (A-D) conversion requirement (per frame) for real-time interfacing with a digital system. Orientation is determined to within +or-2 degrees or better for moderately sized and sufficiently elongated objects. Chip dimensions are 7900 mu m*9200 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multiresolution, error-convergence halftone algorithm (1991)

A new halftone algorithm is described. The algorithm is designed for implementation on a parallel architecture in order to provide fast, progressive coding of moderate-resolution images. The design is based on a multiresolution, hierarchical, pyramidal structure. At each pyramid level, the binarized image is compared with the original, gray-tone image over a successively larger window of pixels for calculation of a weighted averaged error. Within each level, selected binarized pixels are tested for possible changes in the binary assignment. The binary assignment is changed if the change results in a lower average error over the entire window. Varying the selection of test pixels can cause the same process to provide clustered-dot patterns and dithering. A comparison of performance with the best implementation of the error-propagation algorithm is presented visually. Quality is compared also in terms of isotropy of the texture and the appropriate blue-noise characteristics in areas of uniform gray tone. The benefits of this algorithm are realized with moderate-resolution display of the order of 512 dots X 512 dots. The processing can be carried out on smaller blocks since the results can be combined without any visible seams or edge effects.
Stimulating effect of C-reactive protein on phagocytosis of various species of pathogenic bacteria. (1971)

In an investigation of the relationship between the presence of C-reactive protein (CRP) and the promoting effect of the phagocytosis of leucocytes in an in vitro phagocytosis system containing living pathogenic bacteria, it was found that CRP stimulated phagocytosis of Diplococcus pneumoniae, Staph. aureus, E. coli and Klebsiella aerogenes. It appears that CRP is related to non-specific immunity.