gebhart/patrepeval huggingface dataset:
Mammalian inositol monophosphatase: the identification of residues important for the binding of Mg2+ and Li+ ions using fluorescence spectroscopy and site-directed mutagenesis (1993)

The fluorescence properties of residue Trp-219 in inositol monophosphatase are sensitive to the ionization of neighbouring groups. The pH-dependent changes in the fluorescence emission intensity and wavelength of maximum emission appear to arise as the result of two separate ionizations in the proximity of Trp-219, namely due to the ionization of His-217 and Cys-218. By studying the curve of fluorescence intensity against pH, given by the mutants Cys-218-->Ala or His-217-->Gln, the pK of His-217 was determined to be 7.54 and the pK of Cys-218 was estimated to be about 8.2. These mutants have altered kinetic parameters for catalytic Mg2+ ions and inhibitory Mg2+ and Li+ ions. The Cys-218-->Ala mutant enzyme is not subject to inhibition by concentrations of Mg2+ ions up to 400 mM and has a specific activity of 156% of the maximum obtainable activity of the native enzyme. The His-217-->Gln mutant enzyme shows reduced sensitivity to inhibition by Mg2+ and Li+ ions, and has a specific activity of 110% of that obtainable for the native enzyme.
Design solutions for securing SRAM cell against power analysis (2012)

Side channel attacks exploit physical imperfections of hardware to circumvent security features achieved by mathematically secure protocols and algorithms. This is achieved by monitoring physical quantities, usually power consumption or electromagnetic radiation, which contain information about the secret data. As a countermeasure, several circuit styles have been proposed for designing side-channel resistant logic gates and flip-flops. However, little effort has been made to develop secure memory arrays. An SRAM cell with 8 transistors has been proposed in order to obtain power analysis resistance by using a dual-rail precharge principle, the same technique used in various secure logic styles. In this paper we look into the practical aspects of this cell such as noise margins, layout strategy and read current. In addition, we propose alternative solutions for power-analysis resistant SRAM. We compare these solutions in terms of data stability, delay and side-channel resistance.
Tuftsin-Modified Alginate Nanoparticles as a Noncondensing Macrophage-Targeted DNA Delivery System (2012)

The main objective of this study was to evaluate macrophage-targeted alginate nanoparticles as a noncondensing gene delivery system for potential anti-inflammatory therapy. An external gelation method was employed to form plasmid DNA-encapsulated alginate nanoparticles. The nanoparticle surface was modified with a peptide sequence containing tuftsin (TKPR), and transfection efficiency was determined in J774A.1 macrophages. The effect of transfected mIL-10 in blocking expression of tumor necrosis factor-alpha (TNF-α) was evaluated in lipopolysaccharide (LPS)-stimulated cells. Scrambled peptide- and tuftsin-modified cross-linked alginate nanoparticles efficiently encapsulated plasmid DNA and protected against DNase I degradation. The transgene expression efficiencies, measured using GFP and mIL-10 expressing plasmid DNA, were highest with tuftsin-modified nanoparticles. Levels of TNF-α were significantly lower (p < 0.0001) in LPS-stimulated cells that were transfected with mIL-10 using alginate nanoparticles. The results of the study show that noncondensing alginate nanoparticles can efficiently deliver plasmid DNA, leading to sustained in vitro gene expression in macrophages.
Microwave-Induced Retinal Destruction With Sparing of Sclera and Choriocapillaris (1993)

We studied the effect of short-term hyperthermia on sclera, choroid, and retina by delivering microwave radiation (2.45 GHz) for 1 minute to 12 eyes of Dutch belted pigmented rabbits. Four eyes each were treated with 43 degrees C, 45 degrees C, and 47 degrees C and followed for 4 weeks. The 43 degrees C group showed minimal disruption of retinal pigment epithelium and outer retina, with pigment migration; the 45 degrees C and 47 degrees C groups showed complete retinal and RPE damage, pigment migration, and glial proliferation. At the same time, the sclera and choroid in all of the eyes remained essentially unchanged. We conclude that microwave-induced hyperthermia can create retinal scarring without significant damage to sclera and choriocapillaris. The next experimental step will be to refine the microwave delivery system to ensure predictable and reproducible lesions.
A simple pixel structure to compensate non-uniform threshold voltage and mobility of Poly-Si TFTs for large-size AMOLED displays (2013)

A simple pixel structure for large-size and high-resolution active matrix organic light-emitting diode (AMOLED) displays using poly-crystalline silicon (Poly-Si) thin film transistor (TFT) backplane is proposed. The proposed pixel structure can compensate threshold voltage and mobility variations of TFTs. The simulated emission current error range of the proposed pixel structure is from -2.57 LSB to 2.25 LSB when threshold voltage and mobility variations of driving TFT are ±0.5 V and ±10%, respectively. It is expected that the proposed pixel structure will be an effective solution for threshold voltage and mobility variations problem of poly-si TFTs in AMOLED displays.
Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer (2011)

De novo formation of tertiary lymphoid structures (TLS) has been described in lung cancers. Intratumoral TLS seem to be functional and are associated with a long-term survival for lung cancer patients, suggesting that they represent an activation site for tumor-specific T cells. Here, we characterized T-cell recruitment to TLS in human lung cancer to identify the adhesion molecules and chemoattractants orchestrating this migration. We found that most TLS T cells were CD62L+ and mainly of CD4+ memory phenotype, but naive T cells were highly enriched in these structures as compared with the rest of the tumor. A specific gene expression signature associated with T cell presence was identified in TLS, which included chemokines (CCL19, CCL21, CXCL13, CCL17, CCL22, and IL16), adhesion molecules (ICAM-2, ICAM-3, VCAM-1, and MAdCAM-1) and integrins (alphaL, alpha4, and alphaD). The presence of the corresponding receptors on TLS T cells was confirmed. Intratumoral PNAd+ high endothelial venules also were exclusively associated with TLS and colocalized with CD62L+ lymphocytes. Together, these data bring new insights into the T-cell recruitment to intratumoral TLS and suggest that blood T cell enter into TLS via high endothelial venules, which represent a new gateway for T cells to the tumor. Findings identify the molecules that mediate migration of tumor-specific T cells into TLS where T cell priming occurs, suggesting new strategies to enhance the efficacy of cancer immunotherapies.
Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins (2014)

The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) referred to collectively as TDP-43 proteinopathies. To further elucidate mechanisms of pathological TDP-43 processing and identify TDP-43 epitopes that could be useful as potential biomarkers of TDP-43 proteinopathies, we developed a panel of novel monoclonal antibodies (MAbs) directed at regions extending across the length of TDP-43. Here, we confirm previous observations that there is no or minimal accumulation of TDP-43 N-terminal domains in neocortical inclusions in human TDP-43 proteinopathy tissues and we identify a subset of these MAbs that are specific for human versus mouse TDP-43. Notably, one of these MAbs recognized an epitope that preferentially detected pathological TDP-43 inclusions with negligible reactivity for normal nuclear TDP-43 resembling anti-phospho-TDP-43 specific antibodies that only bind pathological TDP-43. Hence, we infer that this new MAb recognizes a phosphorylation independent but disease-specific pathologic conformation in abnormal TDP-43. These data suggest that the novel MAbs reported here will be useful for patient-oriented research as well as for studies of animal and cell-based models of TDP-43 proteinopathies including ALS and FTLD-TDP.
WESTERN STATES TRANSPARENT BORDERS PROJECT: DESCRIPTION OF CURRENT STATE PRACTICES - MONTANA (1993)

As part of a national effort to achieve a more efficient transportation system, the 'transparent borders' concept is aimed at developing technologies and systems that provide a less expensive and more efficient operating environment for commercial vehicle operations (CVO), and ultimately, one which will allow unimpeded passages of trucks across state boundaries. The report results from the first phase of the Transportation Borders Project, a seven-state study to identify the institutional barriers to implementation of various Intelligent Vehicle Highway Systems (IVHS) technologies for CVO. It describes the current practices within state and federal agencies and organizations that affect CVO in Oregon. Particular emphasis is placed on the primary CVO functions in Oregon, including driver and vehicle licensing, operating authority, permitting, tax collection, weight and size regulation, and safety regulation.
High Quality 4H-SiC Epitaxial Layer by Tuning CVD Process (2019)

In this work many steps concerning the epitaxial layer growth on 4H-SiC are studied, evaluated and optimized to obtain high quality 4H-SiC epitaxy. The processes evaluated have been studied on a Hot Wall CVD reactor. The first step related to the substrate surface etching has been tuned by choosing the H2 flow, temperature and process time at which most of defects (mainly stacking faults) are not propagated. Then, the buffer layer step has been optimized by increasing the thickness at which an effective reduction of defect density and an improved electrical performance of power devices have been detected. Also, during the buffer layer growth a strong dependence between basal plane dislocations propagation and the growth rate has been observed. A crucial step carefully studied has been the drift layer growth. It was optimized by increasing the growth rate (13&lt;GR&lt;15µm/h) that results in a lower defectiveness, good thickness and doping uniformity. Final stage concerning the cooling of the process has been strongly revisited. A significant decreasing of the morphological defects (carrots, pits) and stacking faults has been observed by slowing the cool down process (~ 25 °C/min).
Influence of inter-electrode distance on subthalamic nucleus local field potential recordings in Parkinson’s disease (2021)

Differences between LFP12 and LFP03 may offer an opportunity for optimizing adaptive deep brain stimulation (aDBS) protocols for PD. LFP12 can be used to detect β-HFO coupling and β power (i.e. bradykinesia), while LFP03 are optimal for low frequency oscillations (dyskinesias).
History of heart failure and chronic kidney disease and risk of all-cause death after COVID-19 during the first three waves of the pandemic in comparison with influenza outbreaks in Sweden: a registry-based, retrospective, case–control study (2023)

Outcome after COVID-19 is worse if CRD is present. In women at ages <70 years, the presence of CRD attenuates the protective effect of female sex. COVID-19 was associated with higher mortality risk than influenza during the first two pandemic waves.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of (E)‐2‐Methyl‐1‐ alkenyltrimethylstannanes from 1‐Alkynes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multifocus watermarking approach based on discrete cosine transform (2016)

Image fusion process consolidates data and information from various images of same sight into a solitary image. Each of the source images might speak to a fractional perspective of the scene, and contains both "pertinent" and "immaterial" information. In this study, a new image fusion method is proposed utilizing the Discrete Cosine Transform (DCT) to join the source image into a solitary minimized image containing more exact depiction of the sight than any of the individual source images. In addition, the fused image comes out with most ideal quality image without bending appearance or loss of data. DCT algorithm is considered efficient in image fusion. The proposed scheme is performed in five steps: (1) RGB colour image (input image) is split into three channels R, G, and B for source images. (2) DCT algorithm is applied to each channel (R, G, and B). (3) The variance values are computed for the corresponding 8 × 8 blocks of each channel. (4) Each block of R of source images is compared with each other based on the variance value and then the block with maximum variance value is selected to be the block in the new image. This process is repeated for all channels of source images. (5) Inverse discrete cosine transform is applied on each fused channel to convert coefficient values to pixel values, and then combined all the channels to generate the fused image. The proposed technique can potentially solve the problem of unwanted side effects such as blurring or blocking artifacts by reducing the quality of the subsequent image in image fusion process. The proposed approach is evaluated using three measurement units: the average of Q(abf), standard deviation, and peak Signal Noise Rate. The experimental results of this proposed technique have shown good results as compared with older techniques.
Knowledge-aided Signal Detection Algorithm in Non-Gaussian Clutter (2012)

The conventional detection algorithms have poor signal detection performance in non-Gaussian clutter,and the signal detection in non-Gaussian clutter is an important issue in radar signal processing field.In this paper,we consider a signal detection method in non-Gaussian clutter using some prior knowledge about clutter.The statistical characteristics of clutter can be modeled as compound Gaussian process,which is the product of speckle components,which can be modeled as complex Gaussian process,and texture components.Based on the Bayesian methods,using the inverse gamma distribution as the prior distribution of texture components,a knowledge-aided signal detection algorithm is proposed.The computer simulations results show that,the knowledge-aided signal detection algorithm outperform the conventional detection algorithms. Furthermore,in this paper,we use IPIX radar sea clutter data from McMaster University as the object of study,and the prior information of non-Gaussian clutter is obtained using maximum likelihood estimation of clutter data.The detection performance of the algorithm is analyzed,and the results show that,the detection performance of this algorithm is outperform the other conventional signal detection methods,and can achieve a better detection performance in sea clutter data with different resolution.
Pesticides directly accelerate the rate of α‐synuclein fibril formation: a possible factor in Parkinson's disease (2001)

Parkinson's disease involves intracellular deposits of alpha-synuclein in the form of Lewy bodies and Lewy neurites. The etiology of the disease is unknown, however, several epidemiological studies have implicated environmental factors, especially pesticides. Here we show that several pesticides, including rotenone, dieldrin and paraquat, induce a conformational change in alpha-synuclein and significantly accelerate the rate of formation of alpha-synuclein fibrils in vitro. We propose that the relatively hydrophobic pesticides preferentially bind to a partially folded intermediate conformation of alpha-synuclein, accounting for the observed conformational changes, and leading to association and subsequent fibrillation. These observations suggest one possible underlying molecular basis for Parkinson's disease.
Antispasmodic Saponins from Bulbs of Red Onion, Allium cepa L. Var. Tropea (2005)

A phytochemical analysis of the polar extract from the red bulbs of Allium cepa L. var. Tropea, typical of Calabria, a southern region of Italy, was performed extensively for the first time, leading to the isolation of four new furostanol saponins, named tropeoside A1/A2 (1a/1b) and tropeoside B1/B2 (3a/3b), along with the respective 22-O-methyl derivatives (2a/2b and 4a/4b), almost certainly extraction artifacts. High concentrations of ascalonicoside A1/A2 (5a/5b) and ascalonicoside B (6), previously isolated from Allium ascalonicum Hort., were also found. This is the first report of furostanol saponins in this A. cepa variety. The chemical structures of the new compounds were established through a combination of extensive nuclear magnetic resonance, mass spectrometry and chemical analyses. High concentrations of quercetin, quercetin 4(I)-glucoside, taxifolin, taxifolin 7-glucoside, and phenylalanine were also isolated. The new saponins were found to possess antispasmodic activity in the guinea pig isolated ileum; such an effect might contribute to explaining the traditional use of onion in the treatment of disturbances of the gastrointestinal tract.
Simplified Aerodynamic and Structural Modeling for Oblique All-Wing Aircraft. Phase 2: Structures (1994)

Any aircraft preliminary design study requires a structural model of the proposed configuration. The model must be capable of estimating the structural weight of a given configuration, and of predicting the deflections which will result from foreseen flight and ground loads. The present work develops such a model for the proposed Oblique All Wing airplane. The model is based on preliminary structural work done by Jack Williams and Peter Rudolph at Mdng, and is encoded in a FORTRAN program. As a stand-alone application, the program can calculate the weight CG location, and several types of structural deflections; used in conjunction with an aerodynamics model, the program can be used for mission analysis or sizing studies.
Bioremediation Potential of Terrestrial Fuel Spills (1990)

A bioremediation treatment that consisted of liming, fertilization, and tilling was evaluated on the laboratory scale for its effectiveness in cleaning up a sand, a loam, and a clay loam contaminated at 50 to 135 mg g of soil by gasoline, jet fuel, heating oil, diesel oil, or bunker C. Experimental variables included incubation temperatures of 17, 27, and 37 degrees C; no treatment; bioremediation treatment; and poisoned evaporation controls. Hydrocarbon residues were determined by quantitative gas chromatography or, in the case of bunker C, by residual weight determination. Four-point depletion curves were obtained for the described experimental variables. In all cases, the disappearance of hydrocarbons was maximal at 27 degrees C and in response to bioremediation treatment. Poisoned evaporation controls underestimated the true biodegradation contribution, but nevertheless, they showed that biodegradation makes only a modest contribution to gasoline disappearance from soil. Bunker C was found to be structurally recalcitrant, with close to 80% persisting after 1 year of incubation. The three medium distillates, jet fuel, heating oil, and diesel oil, increased in persistence in the listed order but responded well to bioremediation treatment under all test conditions. With bioremediation treatment, it should be possible to reduce hydrocarbons to insignificant levels in contaminated soils within one growing season.
Low Band Gap Polymers Based on Benzo[1,2-b:4,5-b′]dithiophene: Rational Design of Polymers Leads to High Photovoltaic Performance (2010)

This study centers upon the summarized four design criteria for conjugated polymer photovoltaic materials: high oxidation potential, low band gap, a planar symmetrical structure, and high molecular weight. Two polymer materials were synthesized to fulfill these design criteria, both based upon copolymers of benzo[1,2-b:4,5-b′]dithiophene (BnDT) and 4,7-di(2-thienyl)-2,1,3-benzothiadiazole (DTBT). Additional hexyl chains were added to one polymer on the 4 position of the DTBT unit, which increased the molecular weight of the polymer without detracting from its electrochemical or optical properties. Both polymers perform exceptionally well in preliminary bulk heterojunction solar cells, reaching power conversion efficiencies greater than 4%.
Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study (2009)

ClinicalTrials.gov NCT00194519.
A POD MODEL FOR ACOUSTIC EMISSION—DISCUSSION AND STATUS (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. A. Pollock; A POD MODEL FOR ACOUSTIC EMISSION—DISCUSSION AND STATUS. AIP Conference Proceedings 22 February 2010; 1211 (1): 1927–1933. https://doi.org/10.1063/1.3362339 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Ambulance smartphone tool for field triage of ruptured aortic aneurysms (FILTR): study protocol for a prospective observational validation of diagnostic accuracy (2016)

CPMS 16459; pre-results.
Functionalized hydrocarbons with condensed ring skeletons. IX. A trioxotricyclo[8.4.0.02,7]tetradecane (1990)

Le methyl 1,2-trans-1,10-cis-2,7-cis-7-methyl-6,8,14-trioxotricyclo [8.4.0.0 2,7 ] tetradecane-1-carboxylate, C 17 H 22 O 3 − cristallise dans P2 1 /c avec a=10,3072, b=14,9042, c=10,5568 A, β=109,552 o , Z=4; affinement jusqu'a R=0,037. La structure consiste en trois cycles A, B et C a six chainons condenses angulaire. La jonction AB est cis, l'ester C1 et le proton C2 (numerotation IUPAC) sont anti, tandis que la jonction des cycles BC est cis (la structure est raccourcie a CAC). Les cycles A, B et C adoptent chacun une conformation chaise
The reaction between ethyl chloroformate and 2‐picoline: A Correction of the literature. (1978)

SCOPUS: ar.j
Elucidating the Nanoscale Structure of Dinosaur Bone (2013)

Bone is an important material in many scientific disciplines because of its unique structure-property relationships, which are intrinsically dependent on its nanoscale components, bioapatite and collagen. As a living tissue, bone has evolved over hundreds of millions of years, and most vertebrates are now extinct. However, the vast majority of the relevant literature has engaged only modern bone tissues, neglecting the deep time perspective. Why?