MP05-06 MIX METHODS APPROACH TO EXPLORE PATIENTS’ PERSPECTIVES ON THE ACCEPTABILITY OF A URINARY BIOMARKER TEST IN REPLACEMENT OF CYSTOSCOPY FOR BLADDER CANCER SURVEILLANCE (2019)

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP05)1 Apr 2019MP05-06 MIX METHODS APPROACH TO EXPLORE PATIENTS’ PERSPECTIVES ON THE ACCEPTABILITY OF A URINARY BIOMARKER TEST IN REPLACEMENT OF CYSTOSCOPY FOR BLADDER CANCER SURVEILLANCE Wei Shen Tan*, Chin Hai Teo, Delcos Chan, Malgorzata Heinrich, Kuala Lumpur Malaysia, Andrew Feber, Rachael Sarpong, Jennifer Allan, Norman Williams, Chris Brew-Graves, Chirk Jenn Ng, and John Kelly Wei Shen Tan*Wei Shen Tan* More articles by this author , Chin Hai TeoChin Hai Teo More articles by this author , Delcos ChanDelcos Chan More articles by this author , Malgorzata HeinrichMalgorzata Heinrich More articles by this author , Kuala Lumpur MalaysiaKuala Lumpur Malaysia More articles by this author , Andrew FeberAndrew Feber More articles by this author , Rachael SarpongRachael Sarpong More articles by this author , Jennifer AllanJennifer Allan More articles by this author , Norman WilliamsNorman Williams More articles by this author , Chris Brew-GravesChris Brew-Graves More articles by this author , Chirk Jenn NgChirk Jenn Ng More articles by this author , and John KellyJohn Kelly More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000554977.31192.31AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Urine biomarker is an area of much research as an alternative to surveillance cystoscopy. We determine the minimal accepted sensitivity (MAS) of a urine biomarker that patients are willing to accept to replace cystoscopy and to assess their views and reasons. METHODS: Patients were part of a prospective multi-center observational study recruiting patients with bladder cancer for a urine biomarker study (DETECT II; ClinicalTrials.gov: NCT02781428). A mix methods approach comprising of 1) Questionnaire to assess patients' experience with cystoscopy and patients' preference for cystoscopy vs urinary biomarker and 2). Semi-structured interviews to understand patient views, choice and reasons for their preference. RESULTS: A total of 213 patients completed the patient questionnaire. A urine biomarker with MAS of 90% would be accepted by 75.8% of patients. This is despite a high self-reported prevalence of hematuria (51.0%), dysuria/ lower urinary tract symptoms (69.1%) and urinary tract infection requiring antibiotics (25.8%). There was no association between MAS with patient demographics, adverse events experienced, cancer characteristics and distance of patients′ home to hospital. Of the 213 patients who completed the questionnaire, 20 patients were interviewed. Qualitative analysis suggest that patients acknowledge that cystoscopy is invasive, embarrassing and associated with adverse events but are willing to tolerate the procedure due to a high sensitivity. Patients have confidence in cystoscopy and appreciate the visual diagnosis of cancer. Both low and high-risk patients would consider a biomarker with a reported sensitivity similar to cystoscopy. CONCLUSIONS: Patients value the high sensitivity cystoscopy accords despite the reported discomfort and adverse events experienced following cystoscopy. The sensitivity of a urinary biomarker must be close to cystoscopy before patients' acceptance. Source of Funding: The Urology Foundation, The Mason Medical Research Trust, Medical Research Council (MRC) London, United Kingdom; London, United Kingdom; Kuala Lumpur, Malaysia; London, United Kingdom© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e41-e41 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Wei Shen Tan* More articles by this author Chin Hai Teo More articles by this author Delcos Chan More articles by this author Malgorzata Heinrich More articles by this author Kuala Lumpur Malaysia More articles by this author Andrew Feber More articles by this author Rachael Sarpong More articles by this author Jennifer Allan More articles by this author Norman Williams More articles by this author Chris Brew-Graves More articles by this author Chirk Jenn Ng More articles by this author John Kelly More articles by this author Expand All Advertisement PDF downloadLoading ...