gebhart/patrepeval huggingface dataset:
Diversity of Eukaryotic Microorganisms in the Drainage Waters of a Coal Open-Cast Mine (2020)

The composition of the microbiome of acid drainage water of a quarry used for the mining of brown coal was studied. The water had a pH of 5.15 and contained 1.4 g/L of sulfate. Unlike acid mine drainage associated with mining of sulfide ores, the content of iron and heavy metals was low. Molecular analysis of the microbial community was performed by high-throughput sequencing of the 18S and 16S rRNA gene fragments. Most eukaryotic sequences belonged to the fungal phylum Basidiomycota; members of the Chytridiomycota were also found. Basidiomycetes of the family Sporidiobolaceae were the predominant group, as was previously reported for acid mine drainage waters. Among the minor groups, protozoa (Alveolata and Amoebozoa) and green algae (Chlamydomonas) were found. The dominant group of prokaryotes was the genus Acidiphilium (Alphaproteobacteria); betaproteobacteria of the genera Sulfuriferula and Thiomonas were also found.
Psychosocial Outcomes in Adult Survivors of Retinoblastoma (2015)

Most RB survivors do not have poorer psychosocial functioning compared with a noncancer sample. In addition, bilateral and unilateral RB survivors seem similar with respect to their psychological symptoms.
An Integrated Digital Well Logging System (1982)

ABSTRACT Basics of the SLAM Digital Combination Logging System are discussed including an overview which describes each of its major components; the computer-based surface data acquisition system, wellsite analysis software package, and the individual and combination measurement systems used with SLAM. Combination logging runs that are possible with the SLAM system are presented to illustrate their application in a number of different geologic and borehole conditions. The advantages to performing combination logging runs are also discussed. Log presentations available are illustrated to demonstrate methods for diplaying combination log data in usable formats. Diagnostic programs and troubleshooting aids arc reviewed to demonstrate their ability to help predict when equipment is becoming marginal, and to minimize lost time due to equipment failure. Standard methods for performing instrument calibrations are described, including techniques to perform master calibrations at the shop or wellsite, as well as before and after wellsite checks performed with instruments suspended over the borehole, or on the catwalk.
Supplemental Figure 4 from Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor–Positive Breast Cancer (2023)

&lt;p&gt;Supplemental Figure 4: Overview of SSNVs in 68 ctDNA WES samples&lt;/p&gt;
Post-transcriptional Regulation of α-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support (2013)

High ACT plasma levels in HF normalized during LVAD support, which coincides with decreased ACT mRNA in heart tissue, whereas miR-137 levels increased. MiR-137 directly targeted ACT, thereby indicating that ACT and miR-137 play a role in the pathophysiology of HF and reverse remodeling during mechanical support.
The creep strength of the Earth's mantle (1970)

In this paper we show that it is probable that at stresses greater than about 10 −2 bar creep in the earth's mantle is caused by dislocation motion rather than by the mass transport of atoms through diffusion from one grain boundary to another. The latter process leads to Nabarro‐Herring creep. Only at very low stresses (&lt;10 −2 bar) should Nabarro‐Herring creep be dominant. Dislocation creep equations (which are nonlinear in stress) are used to estimate the ‘effective viscosity,’ at a constant creep rate of 10 −16 sec −1 , of the moon, Mars, and the mantles of Venus and the earth. The effective viscosity of the mantles of Venus and the earth diminishes with increasing depth, goes through a minimum, and then increases continuously up to the mantle‐core boundary. The effective viscosity in the lower mantle is much smaller than estimates derived from the Nabarro‐Herring creep equation. The effective viscosity in the deep interior of the moon is approximately constant and does not increase appreciable with depth. The effective viscosity of Mars is intermediate in behavior between that of the earth and of the moon.
Investigation on the removal of the cavitation erosion risk in a control orifice inside a prototype diesel injector (2018)

A CFD investigation is in progress to study the cavitation characteristics and potential erosion risks of a control orifice in a prototype injector. An early design of the orifice resulted in cavitation erosion after endurance testing. A design modification eliminated the erosion and subsequent prototypes were free from damage. Initial results for the two designs using different simulation methods are discussed, along with the effects of different rates of evaporating and condensing mass transfer. Preliminary findings on possible erosion risk indicators comparing the eroding with the non-eroding design are presented.
Reconfigurable 16-channel WDM drop module using silicon MEMS optical switches (1999)

A reconfigurable 16-channel 100-GHz spacing wavelength-division-multiplexed drop module for use at 1550 nm was demonstrated using silicon microelectromechanical system (MEMS) optical switches and arrayed waveguide grating routers. Through-channel extinction was greater than 40 dB and average insertion loss was 21 dB, Both drop-and-retransmit of multiple channels (11-18 dB contrast, 14-19-dB insertion loss) and drop-and-detect of single channels (>20-dB adjacent channel rejection, 10-14-dB insertion loss) were implemented.
The Effect of Fexofenadine on Pruritus in a Mouse Model (HR-ADf) of Atopic Dermatitis (2006)

Fexofenadine, a histamine H1-receptor antagonist, is approved for the treatment of pruritus associated with atopic dermatitis. The effects of fexofenadine on scratching behaviour, and plasma levels of histamine and eotaxin were assessed in a new model of atopic dermatitis. Mice fed a diet low in Mg2+ and Zn2+ (special diet S) were compared with mice on a normal diet (N) or diet S plus fexofenadine HCl for weeks 0-10 (S + F(0-10)), 0-5 (S + F(0-5)) or 6 - 10 (S + F(6-10)) (seven mice per group). Compared with group N, group S mice showed significantly greater scratching frequency, and plasma histamine and eotaxin concentrations; these three variables were significantly lower in group S + F(0-10) than in group S. Scratching frequency increased when fexofenadine was discontinued. Fexofenadine significantly reduced mast cell and eosinophil numbers. Histamine may be important in the pathological changes seen in this model of atopic dermatitis, suggesting that it might aid future development of antihistamines for the treatment of atopic dermatitis.
Differences in peripheral aberrations in age-balanced hyperopes, emmetropes and myopes (2017)

&lt;b&gt;Purpose&lt;/b&gt; Aberrations in the peripheral visual field have been implicated in the development of myopia. Investigators have concentrated on myopes and emmetropes. As significantly higher levels of aberrations have been found on-axis in hyperopes than myopes, this study investigated the differences in peripheral aberrations in hyperopic, emmetropic and myopic groups. &lt;b&gt;Methods&lt;/b&gt; Cycloplegic peripheral aberration for 5 mm pupils was measured at 39 locations across 42° x 32° of right eye fields with a COAS-HD Hartmann-Shack aberrometer in 9 hyperopes (mean age 29 ± 5 years, spherical equivalent refraction M +1.47 ± 0.58 D), 20 emmetropes (28 ± 7 years, +0.06 ± 0.36 D) and 20 myopes (27 ± 6 years, ‒2.55 ± 1.82 D). Relative peripheral refraction error RPRE and 3rd–4th order Zernike coefficients were determined and compared between the groups using repeated measures ANOVAs. &lt;b&gt;Results&lt;/b&gt; Hyperopes and emmetropes had relative peripheral myopia across the visual field, with considerable nasal-temporal asymmetry for both groups and superior-inferior asymmetry for hyperopes. Myopes had minimal RPRE along the horizontal meridian, and less myopic RPRE along the vertical meridian than the other groups. There was little difference between groups in astigmatic components or higher-order Zernike coefficients, except for fourth-order spherical aberration C&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;0&lt;/sup&gt; which was more positive in hyperopes than in both emmetropes (mean difference ± 95% CI = +0.048 ± 0.046 µm, p 0.030) and myopes (+0.067 ± 0.042 µm, p 0.003). Coma changed rapidly across the visual field with similar rates for all the groups. The rates for C&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;1&lt;/sup&gt; along the horizontal meridian (mean rate ‒0.013 µm/degree), were significantly higher than for C&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;-1&lt;/sup&gt; along the vertical meridian (‒0.009 µm/degree). &lt;b&gt;Conclusions&lt;/b&gt; Hyperopes and emmetropes had greater relative peripheral myopia than the myopes. There were asymmetries in RPRE along the vertical meridian for hyperopes which was not present in the emmetropes, suggesting there may be asymmetries in peripheral eye length along the vertical meridian for the former. All higher-order aberrations were affected by field eccentricity, but refractive error affected only the spherical aberration coefficient which was more positive for hyperopes than for other groups. It is unlikely that high levels of aberration contribute to myopia development.
A Rho-related GTPase Is Involved in Ca2+-dependent Neurotransmitter Exocytosis (2000)

Rho, Rac, and Cdc42 monomeric GTPases are well known regulators of the actin cytoskeleton and phosphoinositide metabolism and have been implicated in hormone secretion in endocrine cells. Here, we examine their possible implication in Ca(2+)-dependent exocytosis of neurotransmitters. Using subcellular fractionation procedures, we found that RhoA, RhoB, Rac1, and Cdc42 are present in rat brain synaptosomes; however, only Rac1 was associated with highly purified synaptic vesicles. To determine the synaptic function of these GTPases, toxins that impair Rho-related proteins were microinjected into Aplysia neurons. We used lethal toxin from Clostridium sordellii, which inactivates Rac; toxin B from Clostridium difficile, which inactivates Rho, Rac, and Cdc42; and C3 exoenzyme from Clostridium botulinum and cytotoxic necrotizing factor 1 from Escherichia coli, which mainly affect Rho. Analysis of the toxin effects on evoked acetylcholine release revealed that a member of the Rho family, most likely Rac1, was implicated in the control of neurotransmitter release. Strikingly, blockage of acetylcholine release by lethal toxin and toxin B could be completely removed in <1 s by high frequency stimulation of nerve terminals. Further characterization of the inhibitory action produced by lethal toxin suggests that Rac1 protein regulates a late step in Ca(2+)-dependent neuroexocytosis.
Prevalence of fusB in Staphylococcus aureus clinical isolates (2013)

Fusidic acid (FA) resistance in Staphylococcus aureus markedly varied among different regions. Few data for FA resistance are available in China. In this study, FA susceptibility testing was performed, and the prevalence of fusB and fusC in 116 clinical isolates of S. aureus was investigated by PCR. Mutations in fusA were also determined by sequencing of PCR products. Molecular typing of fusB-positive strains was based on multilocus sequence typing (MLST), spa typing and pulsed-field gel electrophoresis (PFGE). A DNA fragment flanking fusB was sequenced. Transformation experiments were carried out in fusB-positive S. aureus. Of 116 S. aureus including 19 meticillin-resistant S. aureus (MRSA) and 97 meticillin-susceptible S. aureus (MSSA), four (3.5 %) were resistant to FA with MICs of 6-12 µg ml(-1), including one MRSA from blood and three MSSA from wound exudates. All four FA-resistant isolates were found to be fusB gene positive. Three FA-resistant MSSA strains had the same MLST profile of ST630 and spa type of t377, whilst the MRSA strain belonged to ST630-t4549. Only one PFGE pattern was recognized for these four strains. No fusC and fusA mutations were detected in any of the isolates. FA resistance in fusB-positive clinical isolates could be transferred to S. aureus RN4220. The fusB gene was located in a transposon-like element, which had 99 % identity with that found in pUB101. In conclusion, the FA resistance rate is low in S. aureus, and the fusB gene is responsible for the resistance.
LEVELS OF NOREPINEPHRINE AND DOPAMINE IN MOUSE BRAIN REGIONS FOLLOWING MICROWAVE INACTIVATION‐RAPID POST‐MORTEM DEGRADATION OF STRIATAL DOPAMINE IN DECAPITATED ANIMALS (1979)

Abstract —The effects of 2 methods of killing on norepinephrine and dopamine in mouse brain regions were examined. One method utilized decapitation, while the other method utilized heating with microwave irradiation concentrated on the head. The norepinephrine and dopamine contents of the cerebellum, medulla‐pons, midbrain, diencephalon, hippocampus, corpus striatum, and cerebral cortex were determined by methods using liquid chromatography with electrochemical detection. Dopamine content in striatum was also quantitated by the method of gas chromatography with mass fragmentography. A significantly lower value for decapitated animals, as compared to the microwave heated group, was found only for dopamine exclusively in the striatum. Activities of the enzymes tyrosine hydroxylase, DO PA decarboxylase, monoamine oxidase, and catechol‐ o ‐methyltransferase in the striatum were also examined. These enzymes were totally inactivated by the microwave heating, except catechol‐ o ‐methyltransferase which was decreased approx 80%. These results support either (1) the existence of a substantial pool of dopamine in the striatum with a very rapid turnover rate or (2) a decapitation‐related release and destruction of striatal dopamine. Measurements of 3‐methoxytyramine in the striatum exhibit post‐mortem increases corresponding to the decreases of dopamine. Use of the rapid tissue enzyme inactivation technique suggests that in vivo levels of this O ‐methylated dopamine metabolite are an order of magnitude lower than the results normally obtained after killing by decapitation.
Coordinated Regulation of Retinoic Acid Signaling Pathway by KDM5B and Polycomb Repressive Complex 2 (2014)

Polycomb repressive complex 2 (PRC2) is a critical epigenetic regulator in many biological processes, including maintenance of cell identity, stem cell self-renewal, differentiation, and deregulation of PRC2 is often observed in human cancers and diseases. Here we report that KDM5B (PLU-1/JARID1B), a histone lysine demethylase of Jumonji family, associates with PRC2 and colocalizes with PRC2 in nuclear bodies, and their physical association is dependent on direct interaction between KDM5B and the SUZ12 component of PRC2. Interestingly, co-occupancy of KDM5B and PRC2 was evidenced at the conserved cis-regulatory DNA element on retinoic acid (RA) responsive genes. Transcription readout and in vitro pull-down experiments suggest that KDM5B is an essential co-activator, but not a co-repressor, for the RA signaling, and the interface between KDM5B's JMJC domain and retinoic acid receptor α (RARα) is crucial for RA-mediated gene expression. Detailed chromatin immunoprecipitation assays addressed the seemingly paradox by revealing a biphasic effect of KDM5B on RA-induced gene activation through decoupled H3K4me3 demethylation and PRC2-antagonizing activities. These results demonstrate that KDM5B and PRC2 regulate RA signaling cascade in a cooperative and orchestrated fashion.
On design and implementation of a contract monitoring facility (2004)

In this paper we present several solutions to the problem of designing and implementing a contract monitoring facility as part of a larger cross-organisational contract management architecture. We first identify key technical requirements for such a facility and then present our contract language and architecture that address key aspects of the requirements. The language is based on a precise model for the expression of behaviour and policies in the extended enterprise and it can be used to build models for a particular enterprise contract environment. These models can be executed by a contract engine that is part of an overall contract architecture that supports the contract management life cycle at both the contract establishment and contract execution phases. Our solution makes extensive use of the existing open standards.
Yttrium 90 ibritumomab tiuxetan (Zevalin®): A new bullet in the fight against malignant lymphoma? (2007)

Targeted immunotherapy utilizing monoclonal antibodies has improved survival in both indolent and aggressive lymphoma significantly. Since malignant lymphomas are also responsive to radiation, the combination of targeted immunotherapy and radiation with radionuclide coupled to monoclonal antibodies is an attractive option to further improve treatment results. Zevalin is a commercially available variation of the murine anti-CD20 antibody ibritumomab coupled to Yttrium 90 via the tiuxetan chelator. The development of this novel drug as well as the results of the pivotal studies and clinical strategies to implement this treatment into the routine practice of lymphoma oncology are presented in this review.
Development and applicability analysis of intelligent solid state transformer (2011)

The development of intelligent power grid provides a broad market to power electronic equipment. Compared with conventional transformer, intelligent solid state transformer(ISST) is pursuing smart control feature by power electronic converters and comprehensive controlling technology, which aims at voltage regulation, power transmission, isolation, and power quality improvement, etc. This paper analyzed the development of ISST. It highlights the design and application problems of power electronic device, bi-directional DC/DC converter topology and high-frequency transformer. It gives the fundamental terms for further design of ISST. And the future development directions of ISST are also discussed.
Molecular architectures in thin plastic films by in‐situ photopolymerization of reactive liquid crystals (1995)

Abstract— The process of in‐situ photopolymerization of reactive mesogens leads to densely crosslinked liquid crystal (LC) networks. The molecular organization within the thin films can be accurately controlled by combining the various alignment techniques known for low molar mass LCs with the structuring techniques known for photopolymerization. The films thus produced exhibit optical properties useful for polarization control and/or colour control in the various types of LCDs.
The absolute configuration of P-1894B, a potent prolyl hydroxylase inhibitor. (1984)

The previous X-ray-crystallographic determination of the relative configuration of P-1894B, a potent prolyl hydroxylase inhibitor isolated from the culture broth of Streptomyces albogriseolus, was extended by means of chemical and spectral studies. The absolute configuration of P-1894B (1) was established from the absolute configuration of two constituent monosaccharides, L-aculose (3) and L-rhodinose (4), produced by chemical degradation of 1. The absolute configuration of the aglycone part (aquayamycin) was also established as 2. The stereostructure of the reduction product (11) obtained by the catalytic hydrogenation of 1 was also elucidated.
Interações em cadeias alimentares de três níveis que afetam o êxito em projetos de controle biológico (1992)

E desenvolvida a tese de que o conhecimento de padroes num sistema de tres niveis troficos entre plantas, insetos herbivoros e inimigos naturais, e um passo necessario para o desenvolvimento de uma teoria sobre sistemas naturais e controle biologico aplicado. Uma vez descobertos os padroes, torna-se possivel revelar os mecanismos subjacentes, o que contribuira para a sintese e a teoria geral. Os padroes mais fortes sao aqueles que surgem em consequencia da passagem da vegetacao por uma sequencia ecologica de paisagens, assim fornecendo base de sustentacao sobre a qual os insetos herbivoros e seus inimigos naturais devem operar. As plantas oferecem a alimentacao e o habitat para os insetos herbivoros. Consequentemente, a sua distribuicao e abundância impoem a distribuicao dos organismos sobre o sistema de sustentacao alimentar e capacidade de sustentacao para as populacoes herbivoras. Na medida em que diminui o vigor das plantas atraves de uma reducao sucessiva e a biomassa alimenticia aumenta, as populacoes herbivoras mudam de especialistas sobre plantas vigorosas com dinâmicas populacionais latentes, para populacoes nao-especializadas sobre plantas maduras, muitas das quais desenvolvem dinâmicas populacionais eruptivas. Uma conjugacao de varios fatores indica que os inimigos naturais sao relativamente ineficazes nas fases iniciais da sucessao das plantas e que o seu impacto aumenta na medida em que os habitats se tomam mais estaveis e extensivos, e os herbivoros se tornam mais generalizados no aproveitamento do hospedeiro. As inferencias para o controle biologico aplicado sao principalmente que os habitats transitorios, tais como sistemas agricolas, nao sao favoraveis para o controle biologico aplicado. O manejo sofisticado das populacoes de inimigos naturais sera essencial para que os exitos superem os fracassos nesses habitats.
Ant build maintenance with Formiga (2013)

Build refers to the changes made to the build system as a software project evolves over time and has been shown to impose a significant overhead on overall development costs, in part because changes to source code often require parallel changes in the build system. However, little tool support exists to assist developers with build maintenance, particularly for those changes that must accompany changes to the source code. Formiga is a build maintenance and dependency discovery tool for the Ant build system. Formiga's primary uses are to automate build changes as the source code is updated, to assist in build refactoring, to identify the build dependencies within a software project, and to clarify the dependency differences between different versions of build files. Formiga is implemented as an IDE plugin, which allows it to recognize when project resources are updated and automatically update the build system accordingly. This implementation also allows it to leverage existing metaphors used by developers to maintain source code, thus making it easier to use.
Compressive Sensing with structured random matrices (2010)

These notes give a mathematical introduction to compressive sensing focusing on recovery using `1-minimization and structured random matrices. An emphasis is put on techniques for proving probabilistic estimates for condition numbers of structured random matrices. Estimates of this type are key to providing conditions that ensure exact or approximate recovery of sparse vectors using `1-minimization.
o-Bisguanidinobenzene, a Powerful Hydrogen Acceptor:  Crystal Structures of Organic Complexes with Benzoic Acid, Phenol, and Benzyl Alcohol (2004)

An o-phenylenediamine-bisguanidine derivative, o-phenylenebis(N,N‘-dimethyl-N,N‘-ethylene)guanidine (BG), was designed as a powerful hydrogen acceptor. The complexation of BG with a variety of hydrogen donor aromatics carrying OH groups such as benzoic acid (BA), phenol (PH), and benzyl alcohol (BAL) led to the successful isolation of the expected 1 + 1 crystalline complexes, regardless of the acidity of the hydrogen donors. In the case of BA, additional 1 + 2 and 1 + 4 BG−BA crystalline complexes were formed under rigorous conditions of stoichiometry-controlled complexation. These crystals were fully characterized by X-ray crystallographic analysis, indicating that nonbonded interactions in addition to N−H hydrogen bonding play an important role during the crystallization process. Mutual interconversion among the BG−BA crystalline complexes was achieved by the addition of either component to the original complex. Thus, BG was found to act as a powerful hydrogen acceptor in hydrogen bond-based complexation with hydrogen donor aromatics.