gebhart/patrepeval huggingface dataset:
Preparation and characterization of tungsten phenoxo W(OR)4Cl2 complexes (R = pentafluorophenyl, 2,6-dichlorophenyl) and some of their reduction products, including an x-ray study of W(O-2,6-C6H3Cl2)4Cl(Et2O) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of tungsten phenoxo W(OR)4Cl2 complexes (R = pentafluorophenyl, 2,6-dichlorophenyl) and some of their reduction products, including an x-ray study of W(O-2,6-C6H3Cl2)4Cl(Et2O)Richard M. Kolodziej, Richard R. Schrock, and John C. DewanCite this: Inorg. Chem. 1989, 28, 7, 1243–1248Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ic00306a010https://doi.org/10.1021/ic00306a010research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The submucosal fibrosis: what does it mean for colorectal endoscopic submucosal dissection? (2016)

Severe fibrosis is an important factor related to incomplete resection during colorectal ESD. In cases of severe fibrosis, the rate of complete resection was low even when ESD was performed by an experienced operator. Evaluation of submucosal fibrosis may be helpful to predict the submucosal invasion of tumors and technical difficulties in ESD.
The Role of Communicative Feedback in Successful Water Conservation Programs (2011)

The Sacramento County Water Agency has made available 2 water conservation programs to its customers. The Data Logger Program attaches the Meter Master Model 100 EL data logger to the customer's water meter for 1 week and provides a detailed report of water usage from each fixture. The Water Wise House Call Program provides findings and recommendations to participants after an hour-long house call by a trained water efficiency professional. This article reports on the effectiveness of these programs for a sample of 100 participating households. The results indicate that although both programs are effective, the Data Logger Program results in greater water conservation. The role of more informative communicative feedback to customers as an explanation for this finding is discussed. The findings emphasize the importance of providing information that target behavioral changes and the provision of timely feedback of the effect of the behavioral changes to the success of water conservation efforts.
Hydrophilic Antireflection and Antidust Silica Coatings (2021)

We report on the optical and morphological properties of silica thin layers deposited by reactive RF magnetron sputtering of a SiO<sub>2</sub> target under different oxygen to total flow ratios [<i>r</i>(O<sub>2</sub>) = O<sub>2</sub>/Ar, ranging from 0 to 25%]. The refractive index (<i>n</i>), extinction coefficient, total transmission, and total reflectance were systematically investigated, while field-emission scanning electron microscopy, atomic force microscopy, and three-dimensional (3D) average roughness data construction measurements were carried out to probe the surface morphology. Contact angle measurements were performed to assess the hydrophilicity of our coatings as a function of the oxygen content. We performed a thorough numerical analysis using 1D-solar cell capacitance simulator (SCAPS-1D) based on the measured experimental optical properties to simulate the photovoltaic (PV) device performance, where a clear improvement in the photoconversion efficiency from 25 to 26.5% was clearly observed with respect to <i>r</i>(O<sub>2</sub>). Finally, a computational analysis using OptiLayer confirmed a minimum total reflectance of less than 0.4% by coupling a silica layer with <i>n</i> = 1.415 with another high-refractive-index (i.e., >2) oxide layer. These promising results pave the way for optimization of silica thin films as efficient antireflection and self-cleaning coatings to display better PV performance in a variety of locations including a desert environment.
Cell Signaling Studied at the Single‐Cell Level (2010)

This chapter contains sections titled: Introduction Analytes Examined and Reporters Used Cell Preparation and Reporter Loading Cell Lysis and Sampling Techniques Electrophoresis Separation Conditions Detection Automation and Throughput References
Optimising acquisition parameters for myocardial T2 mapping using T2-prep at 3T (2013)

Background T2 mapping using T2-prepared SSFP at 1.5T has been shown to be sensitive to oedema in acute myocardial infarction[1]. At 3T, other studies have addressed the problem of the T2 prep module’s sensitivity to the increased B1 inhomogeneity[2]. However, a second problem is that the lengthened T1 at 3T can reduce the contrast between normal and oedematous myocardium, as well as introducing heart rate variability in measured T2. We set out to develop a protocol which maximised the difference between measured T2 in normal and oedematous tissue, while minimising the heart-rate dependence of the measured T2.
A high-voltage monolithic isolator for a communication network interface (2002)

We have developed a multichannel monolithic isolator that can provide 2.3 kV ac isolation and 100-MHz signal transmission. The isolator uses high-voltage, on-chip isolator technology including trench isolation with buried oxide on the silicon-on-oxide (SOI) substrate and 0.4 /spl mu/m CMOS driver and receiver circuits. This technology lets us produce a four-channel monolithic isolator with an area of 1.5 mm/sup 2/ and a consumption current of 0.5 mA per channel at a frequency of 50 MHz. These operating values suggest that the monolithic isolator can miniaturize the communication interface and reduce power consumption since discrete devices, such as transformers and opto-couplers, are unnecessary. We have also developed a one-chip modem interface LSI that includes the multichannel isolator and an analog front-end circuit.
Sea-Salt Size Distributions from Breaking Waves: Implications for Marine Aerosol Production and Optical Extinction Measurements during SEAS* (2003)

The authors' participation in the Shoreline Environment Aerosol Study (SEAS) involved measurements focused on the coastal aerosol size distribution and related optical measurements, including aerosol light scattering, visibility, and remote sensing of aerosol using lidar backscatter. Aerosol production from shoreline breaking waves and the more distant reef (1 km) was characterized for dry sizes between 0.01 and 10 m for both their contribution to the marine aerosol population and their influence on near-surface lidar extinction. Thermal volatility was used to extract the refractory sea-salt particles from the other constituents volatile at 360C. At 7 m ASL and 20 m inland from the water's edge the production of sea-salt nuclei number was often in the range of 50-100 cm 3 above the open-ocean value of 250 cm 3 . This number peak was near 0.03-m dry diameter, while light scattering was dominated by a few particles larger than 1 m. This indicates that production of sea salt from breaking waves contributes not only to aerosol mass and optical effects but also to nuclei mode particle number in remote regions. Separate studies of optical closure quantified links between the size distribution and optical scattering measurements, visibility, and extinction values for both nearshore breaking waves and openocean conditions. These data confirmed that extinction derived from coastal lidar measurements at 0.530 m was accurate to better than the 25% uncertainty claimed for the lidar inversion.
Decision support for information systems selection (2005)

The main objective of this paper is to explore the applicability of a new procedure to the decision process of information systems selection, the major aspect of which is tackling the uncertainty and imprecision of data, while using the risk as a trade-off measure to prioritize alternative systems. The new procedure consists in a modification of the analytic hierarchy process, where the imprecise decision-maker's judgments are represented as fuzzy numbers. A non-linear optimization method is applied, which derives crisp weights from inconsistent and consistent fuzzy comparison matrices. The weights of the risk factors are then used in an aggregation procedure for selecting the best alternative system.
Multiple cost optimization for task assignment in heterogeneous computing systems using learning automata (2003)

A framework for task assignment in heterogeneous computing systems is presented in this work. The framework is based on a learning automata model. The proposed model can be used for dynamic task assignment and scheduling and can adapt itself to changes in the hardware or network environment. The important feature of the scheme is that it can work on multiple cost criteria, optimizing each criterion individually. The cost criterion could be a general metric like minimizing the total execution time, or an application specific metric defined by the user. The application task is modeled as a task flow graph (TFG), and the network of machines as a processor graph (PG). The automata model is constructed by associating every task in the TFG with a variable structure learning automaton. The actions of each automaton correspond to the nodes in the PG. The reinforcement scheme of the automaton considered is a linear scheme. Different heuristic techniques that guide the automata model to the optimal solution are presented. These heuristics are evaluated with respect to different cost metrics.
Extra-telomeric function of telomerase in rheumatoid arthritis (101.2) (2011)

Abstract Telomerase, an enzyme that adds DNA onto telomeric ends is upregulated in T lymphocytes upon antigen recognition. How telomerase affects T-cell function is unknown. In patients with the autoimmune syndrome rheumatoid arthritis (RA) induction of T-cell telomerase is impaired and associated with premature immunosenescence. To suppress telomerase activity healthy naïve CD4 T cells were stimulated through the T-cell receptor and transfected with control or hTERT-specific siRNA. Telomerase inhibition significantly increased p53 mRNA (p=0.05) and p53 protein (p=0.002). Pro-apoptotic BH3-only proteins were selectively upregulated; PUMA was increased (p=0.04), Noxa and Bim remained unaffected. hTERT silencing doubled frequencies of apoptotic cells. In RA T cells hTERT expression was spontaneously reduced (p&amp;lt;0.0001); immunostaining localized most of the protein to the cytoplasm (p=0.002). Upon TCR ligation RA T cells had higher levels of p53, phosp53 and PUMA. p53 or PUMA knockdown effectively rescued RA T cells from apoptosis. hTERT over-expression suppressed p53 and PUMA and normalized cellular yield. p53 and PUMA silencing did not correct hTERT expression, placing telomerase upstream of the p53-pathway. In conclusion, T-cell telomerase has extra-telomeric functions and regulates life-death decisions after antigenic stimulation. In patients with rheumatoid arthritis, the survival-protective function of telomerase is defective, causing T cell loss and proliferative stress.
Probabilistic Structural Analysis of Adaptive/Smart/Intelligent Space Structures (1992)

A three-bay, space, cantilever truss is probabilistically evaluated for adap tive/smart/intelligent behavior. For each behavior the scatter (ranges) in buckling loads, vibration frequencies and member axial forces are probabilistically determined. Sensitivi ties associated with uncertainties in the structural, material and load variables that describe the truss are determined for different probabilities. The relative magnitude of these sensitivities is used to identify significant truss variables that control/classify its be havior to respond as an adaptive/smart/intelligent structure. Results show that the prob abilistic buckling loads and vibration frequencies increase for each truss classification, with a substantial increase for intelligent trusses. Similarly, the probabilistic member axial forces reduce for adaptive and intelligent trusses and increase for smart trusses.
Safety profile of a polyherbal formulation (Gynocare capsules) in female rats by subchronic oral toxicity study (2012)

Gynocare capsules, is a polyherbal formulation, are used as uterine tonic and for treating gynaecological ailments like infertility, leucorrhea, and menstrual disorders. The formulation contains ingredients of herbal origin, such as, extracts of Ashoka, Vasaka, Durva, Chandan, Musk, and so on. It was evaluated for its safety at the therapeutic dose level by a repeated dose oral toxicity study in albino Wistar rats. The herbal formulation was administered orally at a therapeutic dose of 100 mg/kg/day, for 90 days. All animals were monitored daily for their health status and signs of abnormalities. The body weight, water consumption, and food intake were measured once weekly. At the end of the experimental period, various hematological and biochemical parameters were estimated and histopathologies of selected organs were conducted. The study resulted from the long-term oral administration of Gynocare capsules (100 mg/kg), did not cause any relevant signs of toxicity nor significant changes in the physical, hematological and biochemical parameters. However, statistically significant differences were seen in the relative organ weights of adrenal gland, ovary, and serum creatinine levels. The reduction in ovary weight revealed the possibility of the drug targeting the ovary. Moreover, no pathological features were identified in the treated group as monitored by the histopathological analysis of the internal organs. The study established that Gynocare capsules at the dose given (100 mg/kg) did not induce any remarkable or significant toxic effects, indicating that it was safe in rats following oral administration for 90 consecutive days.
Phenolic Compounds from Globularia cordifolia (2004)

From the methanolic extract of the underground parts of Globularia cordifolia, a new neolignan diglycoside, dehydrodiconiferyl alcohol 9-O-b -D-glucopyranosyl-(1 \\to 2)-b -D-glucopyranoside (1) was isolated along with a known neolignan glycoside, dehydrodiconiferyl alcohol 9-O-b -D-glucopyranoside (2). In addition, 2 flavone glycosides, chrysoeriol 7-O-b -D-allopyranosyl-(1 \\to 2)-b -D-glucopyranoside (3), stachyspinoside (4) and 5 phenylethanoid glycosides, verbascoside (5), isoverbascoside (6), leucosceptoside A (7), martynoside (8) and rossicaside A (9) were obtained and characterized. The structures of the isolates were established by 1D and 2D NMR spectroscopy in combination with IR, UV and MS analysis.
Pulse dynamics in SESAM-free electrically pumped VECSEL (2020)

Self-starting pulsed operation in an electrically pumped (EP) vertical-external-cavity surface-emitting-laser (VECSEL) without intracavity saturable absorber is demonstrated. A linear hemispherical cavity design, consisting of the EP-VECSEL chip and a 10% output-coupler, is used to obtain picosecond output pulses with energies of 2.8 pJ and pulse widths of 130 ps at a repetition rate of 1.97 GHz. A complete experimental analysis of the generated output pulse train and of the transition from continuous-wave to pulsed operation is presented. Numerical simulations based on a delay-differential-equation (DDE) model of mode-locked semiconductor lasers are used to reproduce the pulse dynamics and identify different laser operation regimes. From this, the measured single pulse operation is attributed to FM-type mode-locking. The pulse formation is explained by strong amplitude-phase coupling and spectral filtering inside the EP-VECSEL.
J01 The EHDN advanced therapies working group (ATWG) (2022)

<h3>Background</h3> The ATWG aims to address barriers to the translation of advanced therapies (ATs) for HD, including gene- and cell-based therapies. Most advanced therapies currently require direct delivery of the therapeutic medicine to the brain and are associated with multiple challenges along the translational pipeline, many of which are common across therapeutic approaches. <h3>Aim</h3> To identify operational challenges to the clinical translation of ATs and suggest strategies for moving forwards. <h3>Methods</h3> The ATWG/SC4HD gather preclinical and clinical expertise and provide a combined platform for exchanging and discussing results, bottlenecks and processes to generate a robust clinical development plan applicable to a range of experimental therapeutic approaches. The initial focus of these consortia has been cell therapies. <h3>Results</h3> Over a series of meetings ATWG/SC4HD produced a consensus white paper that identifies the challenges of cell therapy for HD with an emphasis on defining criteria for transitioning to clinical studies (Rosser et al Brain 2022, 145(5):1584-1597). As a next step, two task forces have been set up to identify and optimize salient issues in surgical delivery and clinical trial design. <h3>Conclusions</h3> We have identified challenges associated with the clinical translation of ATs for HD, with a focus on cell therapies, and have set up task forces to gather the necessary expertise to address these challenges whether among the members of ATWG/SC4HD or from other academic programs and industry. This effort is intended to provide guidance to the field, while identifying the most promising avenues to develop ATs for the treatment of HD.
GeoBioMed perspectives on kidney stone recurrence from the reactive surface area of SWL-derived particles (2022)

Shock wave lithotripsy (SWL) is an effective and commonly applied clinical treatment for human kidney stones. Yet the success of SWL is counterbalanced by the risk of retained fragments causing recurrent stone formation, which may require retreatment. This study has applied GeoBioMed experimental and analytical approaches to determine the size frequency distribution, fracture patterns, and reactive surface area of SWL-derived particles within the context of their original crystal growth structure (crystalline architecture) as revealed by confocal autofluorescence (CAF) and super-resolution autofluorescence (SRAF) microscopy. Multiple calcium oxalate (CaOx) stones were removed from a Mayo Clinic patient using standard percutaneous nephrolithotomy (PCNL) and shock pulse lithotripsy (SPL). This produced approximately 4-12 mm-diameter PCNL-derived fragments that were experimentally treated ex vivo with SWL to form hundreds of smaller particles. Fractures propagated through the crystalline architecture of PCNL-derived fragments in a variety of geometric orientations to form rectangular, pointed, concentrically spalled, and irregular SWL-derived particles. Size frequency distributions ranged from fine silt (4-8 μm) to very fine pebbles (2-4 mm), according to the Wentworth grain size scale, with a mean size of fine sand (125-250 μm). Importantly, these SWL-derived particles are smaller than the 3-4 mm-diameter detection limit of clinical computed tomography (CT) techniques and can be retained on internal kidney membrane surfaces. This creates clinically undetectable crystallization seed points with extremely high reactive surface areas, which dramatically enhance the multiple events of crystallization and dissolution (diagenetic phase transitions) that may lead to the high rates of CaOx kidney stone recurrence after SWL treatment.
Liver Disease and the PI ElembergM Phenotype of Alpha1-Antitrypsin (1985)

The purpose of this article is to document clinical and pathologic observations concerning liver disease associated with the PI ElembergM phenotype of alpha1-antitrypsin. Deposits of alpha1-antitrypsin that were periodic acid-Schiff positive and stained with an antiserum to alpha1-antitrypsin were found in the liver of a markedly jaundiced, terminally ill patient with Stage IV primary biliary cirrhosis. A biopsy performed three years earlier failed to reveal alpha1-antitrypsin deposits. The phenotype PI ElembergM was verified by both acid starch gel electrophoresis and isoelectric focusing in agarose. The deposits of alpha1-atitrypsin in the liver appear to be a consequence of the patient’s disease and age and not due to an association with the PI*Elemberg allele. Accumulation of alpha1-antitrypsin in the liver of this patient may be due to an accelerated synthesis of this protease inhibitor exceeding the liver’s capacity for glycosylation or other steps in its secretion.
Isotopic Equivalence from Bezier Curve Subdivision (2012)

We prove that the control polygon of a Bezier curve B becomes homeomorphic and ambient isotopic to B via subdivision, and we provide closed-form formulas to compute the number of iterations to ensure these topological characteristics. We first show that the exterior angles of control polygons converge exponentially to zero under subdivision.
Clathrin Hub Expression Dissociates the Actin-Binding Protein Hip1R from Coated Pits and Disrupts Their Alignment with the Actin Cytoskeleton (2001)

The actin cytoskeleton has been implicated in the maintenance of discrete sites for clathrin-coated pit formation during receptor-mediated endocytosis in mammalian cells, and its function is intimately linked to the endocytic pathway in yeast. Here we demonstrate that staining for mammalian endocytic clathrin-coated pits using a monoclonal antibody against the AP2 adaptor complex revealed a linear pattern that correlates with the organization of the actin cytoskeleton. This vesicle organization was disrupted by treatment of cells with cytochalasin D, which disassembles actin, or with 2,3-butanedione monoxime, which prevents myosin association with actin. The linear AP2 staining pattern was also disrupted in HeLa cells that were induced to express the Hub fragment of the clathrin heavy chain, which acts as a dominant-negative inhibitor of receptor-mediated endocytosis by direct interference with clathrin function. Additionally, Hub expression caused the actin-binding protein Hip1R to dissociate from coated pits. These findings indicate that proper function of clathrin is required for coated pit alignment with the actin cytoskeleton and suggest that the clathrin-Hip1R interaction is involved in the cytoskeletal organization of coated pits.
The epitope landscape of CRC liver metastases analyzed by whole-exome sequencing and in silico epitope prediction (2014)

Many cancers appear to have an increased somatic mutation rate. Intriguingly, increased numbers of tumor-infiltrating T cells are often found in cancers with defective DNA repair, which especially accumulate high numbers of somatic mutations. These observations indicate that an accumulation of mutations could generate a number of neo-antigens that could be recognized by the immune system. Many studies have focused on identifying such neo-antigens recognized by tumor-infiltrating lymphocytes (TILs), and a number of point mutations in a wide variety of genes have already been shown to be recognized by CD4+ and CD8+ TILs. It has been further shown that TILs play an important role for tumor progression. In primary colorectal cancer (CRC) for example, high densities of TILs have been repeatedly associated with an improved survival rate.