gebhart/patrepeval huggingface dataset:
Regioselective Complexation of Unprotected Carbohydrates by Platinum(II): Synthesis, Structure, Complexation Equilibria, and Hydrogen-Bonding in Carbonate-Derived Bis(phosphine)platinum(II) Diolate and Alditolate Complexes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective Complexation of Unprotected Carbohydrates by Platinum(II): Synthesis, Structure, Complexation Equilibria, and Hydrogen-Bonding in Carbonate-Derived Bis(phosphine)platinum(II) Diolate and Alditolate ComplexesMark A. Andrews, Eric J. Voss, George L. Gould, Wim T. Klooster, and Thomas F. KoetzleCite this: J. Am. Chem. Soc. 1994, 116, 13, 5730–5740Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00092a025https://doi.org/10.1021/ja00092a025research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Optical coatings for document security (1996)

Optical coatings that shift color with viewing angle have been adapted into optically variable foils, pigments, and inks to prevent color copying by color copiers, printers, cameras, or lithographic reproduction. Metal-dielectric multilayer thin-film structures have large color shifts with angle, high chroma, a large color gamut, and light fastness that make them uniquely suited for security inks. World currencies are now protected by these structures.
Genetic Analysis of Dengue Virus in Severe and Non-Severe Cases in Dhaka, Bangladesh, in 2018–2022 (2023)

Dengue virus (DENV) infections have unpredictable clinical outcomes, ranging from asymptomatic or minor febrile illness to severe and fatal disease. The severity of dengue infection is at least partly related to the replacement of circulating DENV serotypes and/or genotypes. To describe clinical profiles of patients and the viral sequence diversity corresponding to non-severe and severe cases, we collected patient samples from 2018 to 2022 at Evercare Hospital Dhaka, Bangladesh. Serotyping of 495 cases and sequencing of 179 cases showed that the dominant serotype of DENV shifted from DENV2 in 2017 and 2018 to DENV3 in 2019. DENV3 persisted as the only representative serotype until 2022. Co-circulation of clades B and C of the DENV2 cosmopolitan genotype in 2017 was replaced by circulation of clade C alone in 2018 with all clones disappearing thereafter. DENV3 genotype I was first detected in 2017 and was the only genotype in circulation until 2022. We observed a high incidence of severe cases in 2019 when the DENV3 genotype I became the only virus in circulation. Phylogenetic analysis revealed clusters of severe cases in several different subclades of DENV3 genotype I. Thus, these serotype and genotype changes in DENV may explain the large dengue outbreaks and increased severity of the disease in 2019.
Magnetic particle– based sandwich immunoassay on interdigitated electrodes. Application for CARCINOEMBRYONIC ANTIGEN determinaton (2015)

International audience
Human natural killer cell development (2006)

Our understanding of human natural killer (NK) cell development lags far behind that of human B- or T-cell development. Much of our recent knowledge of this incomplete picture comes from experimental animal models that have aided in identifying fundamental in vivo processes, including those controlling NK cell homeostasis, self-tolerance, and the generation of a diverse NK cell repertoire. However, it has been difficult to fully understand the mechanistic details of NK cell development in humans, primarily because the in vivo cellular intermediates and microenvironments of this developmental pathway have remained elusive. Although there is general consensus that NK cell development occurs primarily within the bone marrow (BM), recent data implicate secondary lymphoid tissues as principal sites of NK cell development in humans. The strongest evidence stems from the observation that the newly described stages of human NK cell development are naturally and selectively enriched within lymph nodes and tonsils compared with blood and BM. In the current review, we provide an overview of these recent findings and discuss these in the context of existing tenets in the field of lymphocyte development.
Regulation of Plant Primary Metabolism – How Results From Novel Technologies Are Extending Our Understanding From Classical Targeted Approaches (2022)

The post-genomic era is characterized by a range of high throughput profiling methods capable of broadly characterizing gene expression levels, protein, and metabolite abundances. Application of these methods, enzyme profiling, and more recently, protein-metabolite interactions and flux analysis have alongside modeling approaches allowed us to refine our understanding of the regulation of metabolism even in the case of the canonical pathways of primary plant metabolism. Here we review recent insights obtained by using such methods in the context of our previous knowledge. In doing so, we hope to highlight the effectiveness of these methods and postulate that their application to less well-studied metabolic pathways will likely allow the elucidation of the hitherto unknown mechanism of metabolic regulation.
Wideband Antenna Arrays with Reconfigurable Beamforming and Beamshaping (2007)

The paper gives an overview of research results from FOI on dual polarized phased array antennas and integrated beamforming components for wideband and wide-angle beamforming. The electromagnetic design and experimental evaluation of two antenna arrays in the 2-6 and 6-18 GHz bands, with 2 x 7 x 8 elements each, is described. The electromagnetic performance has been simulated using commercial and in-house developed codes. Experimental evaluation show that the arrays have reflection levels below -10 dB and good radiation properties in a frequency range of up to 1:3 and scan angles of up to 60deg. A concept with wideband reconfigurable beamforming with frequency tapered aperture areas is also presented. Two objectives are to enable adaptation of beamwidths to different requirements, and to enable a frequency independent beamwidth over a wide frequency range. Components for wideband beamforming with MMIC true-time delays and reconfigurable active power distribution working in the 2-18 GHz range are also presented.
Contraceptive Failure, Method-Related Discontinuation and Resumption of Use: Results from the 1995 National Survey of Family Growth (1999)

The risks of pregnancy during typical use of reversible methods of contraception are considerably higher than risks of failure during clinical trials, reflecting imperfect use of these methods rather than lack of inherent efficacy. High rates of method-related discontinuation probably reflect dissatisfaction with available methods.
Effect of recipient-derived cells on the progression of familial amyloidotic polyneuropathy after liver transplantation: a retrospective study (2010)

Although the FAP patient had recipient-derived cells in the transplanted liver, the recipient-derived cells did not contribute to the production of ATTR in our specific case. The effect of recipient-derived cells on the post-transplant progression of FAP symptoms may be negligible.
Optimal Constellations for the Pragmatic Receiver in the DVB-S2 Standard (2013)

In this paper we use a variation of simulated annealing algorithm for optimizing two-dimensional constellations with up to 32 signals. We focus on optimizing the \emph{pragmatic} average mutual information, which is shown to be the relevant measure for pragmatic schemes usually adopted in the receiver. The method allows the joint optimization of constellation and binary labeling. We investigate the performance of the optimized constellation over both AWGN channel and nonlinear satellite channel. The optimized constellations perform considerably better than the conventional Amplitude Phase Shift Keying (APSK) modulations over the AWGN, used in the current digital video broadcasting standard (DVB-S2). As for the nonlinear channel, we consider the so called Soft Limiter model for the high power amplifier. We provide simulation results in realistic scenarios using the DVB-S2 standard LDPC to show the gains obtained by the proposed constellations.
Jigsaw: scalable software-defined caches (2013)

A single-ISA heterogeneous chip multiprocessor (HCMP) is an attractive substrate to improve single-thread performance and energy efficiency in the dark silicon era. We consider HCMPs comprised of non-monotonic core types where each core type is performance-optimized to different instruction-level behavior and hence cannot be ranked - different program phases achieve their highest performance on different cores. Although non-monotonic heterogeneous designs offer higher performance potential than either monotonic heterogeneous designs or homogeneous designs, steering applications to the best-performing core is challenging due to performance ambiguity of core types.
Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target (2021)

Enveloped viruses belong to a large class of pathogens responsible for multiple serious diseases. Their spread into new territories has been the cause of major epidemics throughout human history, including the Spanish flu in 1918 and the latest COVID-19 pandemic. Thanks to their outer membrane, consisting essentially of host lipids, enveloped viruses are more resistant to enzymes and are also less susceptible to host immune defenses than their naked counterparts. Therefore, the development of effective approaches to combat enveloped virus infections represents a major challenge for antiviral therapy in the current century. This review focuses on the characteristics of enveloped viruses, their importance in the entry phase, drugs targeting envelope membrane- mediated entry, and those specifically designed to target the envelope. The broad- -spectrum antiviral activity of these compounds can be attributed to their ability to affect the envelope, an essential structural feature common to several viruses. This makes this class of compounds agents of great interest when no specific drugs or vaccines are available to block viral infections.
Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle (2021)

Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT<sub>1</sub> receptor, which couples to both G<sub>q</sub> and G<sub>i</sub> proteins, and the MT<sub>2</sub> receptor, which couples to G<sub>i</sub>. We investigated whether melatonin receptors are expressed on airway smooth muscle; whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca<sup>2+</sup>]<sub>i</sub>), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation. We detected the mRNA and protein expression of the melatonin MT<sub>2</sub> but not the MT<sub>1</sub> receptor in native human and guinea pig airway smooth muscle and cultured human airway smooth muscle (HASM) cells by RT-PCR, immunoblotting, and immunohistochemistry. Activation of melatonin MT<sub>2</sub> receptors with either pharmacological concentrations of melatonin (10-100 µM) or the nonselective MT<sub>1</sub>/MT<sub>2</sub> agonist ramelteon (10 µM) significantly inhibited forskolin-stimulated cAMP accumulation in HASM cells, which was reversed by the Gα<sub>i</sub> protein inhibitor pertussis toxin or knockdown of the MT<sub>2</sub> receptor by its specific siRNA. Although melatonin by itself did not induce an initial [Ca<sup>2+</sup>]<sub>i</sub> increase and airway contraction, melatonin significantly potentiated acetylcholine-stimulated [Ca<sup>2+</sup>]<sub>i</sub> increases, stress fiber formation through the MT<sub>2</sub> receptor in HASM cells, and attenuated the relaxant effect of isoproterenol in guinea pig trachea. These findings suggest that the melatonin MT<sub>2</sub> receptor is expressed in ASM, and modulates airway smooth muscle tone via reduced cAMP production and increased [Ca<sup>2+</sup>]<sub>i</sub>.
Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas (2020)

Despite significant improvements in surgical and medical management, high grade serous ovarian cancer (HGSOC) still represents the deadliest gynecologic malignancy and the fifth most frequent cause of cancer-related mortality in women in the USA. Since DNA repair alterations are regarded as the "the Achille's heel" of HGSOC, both DNA homologous recombination and DNA mismatch repair deficiencies have been explored and targeted in epithelial ovarian cancers in the latest years. In this review, we aim at focusing on the therapeutic issues deriving from a faulty DNA repair machinery in epithelial ovarian cancers, starting from existing and well-established treatments and investigating new therapeutic approaches which could possibly improve ovarian cancer patients' survival outcomes in the near future. In particular, we concentrate on the role of both Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPis) and immune checkpoint inhibitors in HGSOC, highlighting their activity in relation to BRCA1/2 mutational status and homologous recombination deficiency (HRD). We investigate the biological rationale supporting their use in the clinical setting, pointing at tracking their route from the laboratory bench to the patient's bedside. Finally, we deal with the onset of mechanisms of primary and acquired resistance to PARPis, reporting the pioneering strategies aimed at converting homologous-recombination (HR) proficient tumors into homologous recombination (HR)-deficient HGSOC.
OC 8546 SAFETY AND IMMUNOGENICITY OF THE MALARIA VACCINE CANDIDATE BK-SE36 IN YOUNG CHILDREN LIVING IN BURKINA FASO (2019)

Background The malaria blood stage vaccine candidate SE-36 is based on the serine repeat antigen of Plasmodium falciparum . Epidemiological studies have shown that antibodies against SE36 correlate with lower parasitaemia in Solomon Island residents. In a phase I b trial conducted in Uganda, the BK-SE36 vaccine, SE36 formulated with aluminium hydroxide gel, was found safe and immunogenic. Interestingly, highest levels of IgG anti-SE36 protein associated with protection against severe malaria were found in the youngest Ugandan trial participants. Objectives To assess the safety and immunogenicity of the BK-SE36 vaccine in a randomised controlled double-blind age de-escalating phase Ib clinical trial in younger (≤5 years) malaria-exposed children living in Burkina Faso. Methods Healthy participants (108) were included in two age cohorts, one consisting of 54 children aged 25–60 months and the other of 54 children aged 12–24 months. Trial participants received 3 intramuscular or subcutaneous injections of the BK-SE36 vaccine at Day 0, Week 4 and 26. Participants allocated to the control group received the control Synflorix vaccine via intramuscular route at Day 0 and Week 26 and saline at Week 4. The participants were followed for one year. Immune responses were evaluated by ELISA, ELISpot and parasite carriage by microscopy and PCR. Results Preliminary data from an interim analysis (data collected one month after the last immunisation) indicated that the vaccine was safe, well-tolerated and induced an IgG anti-SE36 response in these younger populations. The trial’s latest safety, immunogenicity and preliminary efficacy results will be presented.
Abstract 4729: Targeting c-MYCdegradation as a novel therapeutic strategy for osteosarcoma: Studies in canine and human osteosarcoma cells (2019)

Abstract Osteosarcoma (OS) is the most common bone tumor in both humans and dogs, and has a nearly ten-fold higher incidence in dogs than humans. For the past twenty years, despite advances in treatment of other cancers, the overall survival rates for OS have stagnated. Thus, there is a great need for novel therapeutic strategies. In osteosarcoma, MYC activation is critical for both initiation and maintenance of tumorigenesis and tissue invasion. While targeting c-MYC is a rational strategy to treat OS, c-MYC has evaded therapeutic manipulation to date. In this study, we evaluated using a novel proteasome modulator, TCH-165, which induces c-MYC degradation, and compared it with convention treatments in in vitro studies. We demonstrated dose dependent decrease of c-MYC protein expression with TCH-165 treatment. Utilizing seven canine OS cell lines and three human OS cell line, we determined that the IC50 values for TCH-165 range from 2.2 to 11.6 μM in canine OS, 3.1 to 4.5 μM in human OS cell lines, while IC50 of several primary canine ranged from 22.3 μM to &amp;gt;200μM, suggesting a wide margin of safety. In cell cycle studies, we showed that TCH-165 resulted in G1 arrest after 12 hours of incubation. In addition, we examined the potential of combing TCH-165 with convention therapeutic agents. We selected carboplatin, one of the standard anti-tumor drugs for OS. Combination index calculations using TCH-165 and carboplatin in the canine D17 cell line support synergistic effects of this combination. The data point to potential novel avenues for treatment of OS which can be further examined in proof of concept studies in dogs with OS, serving as a relevant translational model, and accelerate drug development for human OS patients. Citation Format: Ya-Ting Yang, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe. Targeting c-MYCdegradation as a novel therapeutic strategy for osteosarcoma: Studies in canine and human osteosarcoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4729.
Centrifugation and Fast Firing of a Commercial BaTiO<inf>3</inf>Powder (1986)

Commercial BaTiO3.powder of approximately lpm average particle size was subjected to three independent treatments to reduce fired grain size: fast firing, centrifugal classification, and doping. The 1370°C conventional firing produced 90+w grains in both undoped samples. In the doped sample conventional firing produced 7.0pm grains. Fast firing (1450°C) produced 20pm (undoped, not centrifuged), 13um (undoped, centrifuged), and 3pm (doped, not centrifuged) grain sizes at approximately 98% theoretical density. Measurements of grain size and porosity of samples removed at intervals during firing confirm these trends. Therefore it is found that all three variables reduce grain growth. centrifugation was reduced by the small number of particles in the 0.6-0.7 m range which would tend to grow at the expense of the rest of the particles. A narrower centrifuged cut would lead to less chance of grain growth but a submicron fired grain size in an undoped powder appears unlikely without at least small dopant additions. The effect of
Adaptation of Precision Matrix Models on Large Vocabulary Continuous Speech Recognition (2006)

Recently, structured precision matrix models were found to outperform the conventional diagonal covariance matrix models. Minimum phone error discriminative training of these models gave very good unadapted performance on large vocabulary continuous speech recognition systems. To obtain state-of-the-art performance, it is important to apply adaptation techniques efficiently to these models. In this paper, simple row-by-row iterative formulae are described for both MLLR mean and constrained MLLR transform estimations of these models. These update formulae are derived within the standard expectation maximisation framework and are guaranteed to increase the likelihood of the adaptation data. Efficient approximate schemes for these adaptation methods are also investigated to further reduce the computation. Experimental results are presented based on the MPE trained subspace for precision and mean models, evaluated on both broadcast news and conversational telephone speech English tasks.
Dihydrostilbenes of Cannabis. Synthesis of canniprene (1982)

Canniprene (10) is synthesised via reaction of a phenolate-anion ylide with a benzyl-protected aldehyde. Benzoylation, followed by hydrogenation and hydrogenolysis of the resulting stilbene, leads to a half-benzoylated bibenzyl which is converted into its O-dimethylprop-2-ynyl derivative. Semi-hydrogenation, Claisen rearrangement, and debenzoylation gives canniprene. In a second synthesis the prenylated (3-methylbut-2-enylated) and benzyl-protected ring-B section is made first and converted by Wittig reaction into a dibenzyl-protected stilbene. The stilbene is reduced and the benzyl groups removed in one step, without affecting the prenyl group, by sodium in butanol: magnesium in methanol is capable of stilbene reduction without debenzylation. This practical synthesis proceeds in 19% overall yield from the dimethylprop-2-ynyl ether of isovanillin (14) and is applicable to isotope-labelling. The use of p-bromophenacyl (PBP) ether and methoxyethoxymethyl (MEM) ether protection as the basis for canniprene synthesis is also considered.Other bibenzyls relevant to the natural products of Cannabis are made and the methylated chroman (37) derived from canniprene is also synthesised.
My winding trail while fulfilling my love for science and family (2018)

My winding path toward a career in science was awkward, like an adolescent finding an identity. It did not follow a classic course; it had many interruptions, complications, and challenges. It also involved a bit of luck and extremely supportive colleagues, mentors, and family, including my husband, children, and in-laws. I was inspired to tell my story here because I met a young woman interviewing in 2018 for graduate school who is growing up with the same complicated family expectations, social challenges, love for science, and desire to be a scientist as I had four decades ago. Her future is uncertain, because her chosen academic path is not encouraged by those around her. We, as a society, must find ways to encourage, promote, enable, and give strength to those who want to follow their dreams, despite facing many challenges in their lives. Here are some things I learned on my career path that I hope might be helpful for others.