gebhart/patrepeval huggingface dataset:
John Nathan: Mishima: a biography. xx, 300 pp. London: Hamish Hamilton, 1975. £4.50. (1976)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Action Image Representation: Learning Scalable Deep Grasping Policies\n with Zero Real World Data (2020)

This paper introduces Action Image, a new grasp proposal representation that\nallows learning an end-to-end deep-grasping policy. Our model achieves $84\\%$\ngrasp success on $172$ real world objects while being trained only in\nsimulation on $48$ objects with just naive domain randomization. Similar to\ncomputer vision problems, such as object detection, Action Image builds on the\nidea that object features are invariant to translation in image space.\nTherefore, grasp quality is invariant when evaluating the object-gripper\nrelationship; a successful grasp for an object depends on its local context,\nbut is independent of the surrounding environment. Action Image represents a\ngrasp proposal as an image and uses a deep convolutional network to infer grasp\nquality. We show that by using an Action Image representation, trained networks\nare able to extract local, salient features of grasping tasks that generalize\nacross different objects and environments. We show that this representation\nworks on a variety of inputs, including color images (RGB), depth images (D),\nand combined color-depth (RGB-D). Our experimental results demonstrate that\nnetworks utilizing an Action Image representation exhibit strong domain\ntransfer between training on simulated data and inference on real-world sensor\nstreams. Finally, our experiments show that a network trained with Action Image\nimproves grasp success ($84\\%$ vs. $53\\%$) over a baseline model with the same\nstructure, but using actions encoded as vectors.\n
Carcinoid Tumors (2008)

Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the enterochromaffin cells disseminated throughout the gastrointestinal and bronchopulmonary systems. Though they have been traditionally classified based on embryologic site of origin, morphologic pattern, and silver affinity, newer classification systems have been developed to emphasize the considerable clinical and histopathologic variability of carcinoid tumors found within each embryologic site of origin. These neoplasms pose a diagnostic challenge because they are often innocuous at the time of presentation, emphasizing the need for a multidisciplinary diagnostic approach using biochemical analysis, standard cross-sectional imaging, and newer advances in nuclear medicine. Similarly, treatment of both primary and disseminated carcinoid disease reflects the need for a multidisciplinary approach, with surgery remaining the only curative modality. The prognosis for patients with these tumors is generally favorable; however, it can be quite variable and is related to the location of the primary tumor, extent of metastatic disease at initial presentation, and time of diagnosis.
Whole-bowel irrigation versus activated charcoal in sorbitol for the ingestion of modified-release pharmaceuticals (1989)

Overdose with modified-release pharmaceuticals is an increasing phenomenon. This study examines whole-bowel irrigation as a potential decontamination strategy after overdose with enteric-coated acetylsalicylic acid and compares it with administration of activated charcoal in sorbitol, which is currently the recommended intervention. A three-phase randomized crossover protocol was used in 10 adult volunteers. Each volunteer ingested nine 325 mg doses of enteric-coated acetylsalicylic acid on three occasions, with at least 1 week between each administration period. Serum samples were analyzed for salicylic acid concentration by HPLC. Both interventions decreased peak salicylic acid concentration, time-to-zero salicylic acid concentration, and AUC when compared with control (p less than 0.01). Whole-bowel irrigation was superior to activated charcoal in sorbitol by all three criteria (p less than 0.05). Adverse effects were qualitatively and quantitatively greater during activated charcoal in sorbitol, and the volunteers preferred whole-bowel irrigation over charcoal in sorbitol. Our data suggest that whole-bowel irrigation should be considered for overdose of other modified-release pharmaceuticals.
Blind One-Bit Compressive Sampling (2013)

The problem of 1-bit compressive sampling is addressed in this paper. We introduce an optimization model for reconstruction of sparse signals from 1-bit measurements. The model targets a solution that has the least l0-norm among all signals satisfying consistency constraints stemming from the 1-bit measurements. An algorithm for solving the model is developed. Convergence analysis of the algorithm is presented. Our approach is to obtain a sequence of optimization problems by successively approximating the l0-norm and to solve resulting problems by exploiting the proximity operator. We examine the performance of our proposed algorithm and compare it with the binary iterative hard thresholding (BIHT) [10] a state-of-the-art algorithm for 1-bit compressive sampling reconstruction. Unlike the BIHT, our model and algorithm does not require a prior knowledge on the sparsity of the signal. This makes our proposed work a promising practical approach for signal acquisition.
Picornavirus Inhibitors: Trifluoromethyl Substitution Provides a Global Protective Effect against Hepatic Metabolism (1995)

Several modifications of the oxazoline ring of WIN 54954, a broad spectrum antipicornavirus compound, have been prepared in order to address the acid lability and metabolic instability of this compound. We have previously shown that the oxadiazole analogue 3 displayed comparable activity against a variety of rhinoviruses and appeared to be stable to acid. A monkey liver microsomal assay was developed to examine the metabolic stability in vitro of both compounds, and it was determined that WIN 54954 displayed 18 metabolic products while 3 was converted to 8 products. Two major products of 3 were determined by LC-MS/MS to be monohydroxylated at each of the terminal methyl groups. Replacement of the methyl on the isoxazole ring with a trifluoromethyl group, while preventing hydroxylation at this position, did not reduce the sensitivity of the molecule to microsomal metabolism at other sites. However, the (trifluoromethyl)oxadiazole 9 not only prevented hydroxylation at this position but also provided protection at the isoxazole end of the molecule, resulting in only two minor products to the extent of 4%. The major product was identified as the monohydroxylated compound 23. The global metabolic protective effect of trifluoromethyl group on the oxadiazole ring was further demonstrated by examining a variety of analogues including heterocyclic replacements of the isoxazole ring. In each case, the trifluoromethyl analogue displayed a protective effect when compared to the corresponding methyl analogue.
Optical Analysis Software As An Application For Three-Dimensional Display (1984)

Presented is a discussion of the potential value of three-dimensional displays augmenting optical design software. Specifically, we discuss physical optics modeling methods and a configuration-based approach, which allows users to view the optical system in a three-dimensional projection. This approach utilizes elementary ray-trace capabilities used in providing geometric beam data to the physical optics part of the code. A global three-dimensional coordinate system provides a framework in which to locate components, and compute beam intercepts with the components in the optical systems.
Remixed Reality (2018)

We present Remixed Reality, a novel form of mixed reality. In contrast to classical mixed reality approaches where users see a direct view or video feed of their environment, with Remixed Reality they see a live 3D reconstruction, gathered from multiple external depth cameras. This approach enables changing the environment as easily as geometry can be changed in virtual reality, while allowing users to view and interact with the actual physical world as they would in augmented reality. We characterize a taxonomy of manipulations that are possible with Remixed Reality: spatial changes such as erasing objects; appearance changes such as changing textures; temporal changes such as pausing time; and viewpoint changes that allow users to see the world from different points without changing their physical location. We contribute a method that uses an underlying voxel grid holding information like visibility and transformations, which is applied to live geometry in real time.
Diagnostic fault detection for internal combustion engines via norm based map projections (2004)

One proven technique for monitoring health of a sealed internal combustion engine is to analyze combustion pressure cycle curves of the individual cylinders. Most techniques that are available are either overly simplistic or rely on artificial intelligence based methodologies such as neural networks. While neural network based methods can be useful, there is normally no quantitatively hard way to determine how accurately a trained neural network represents the desired goal. For this reason, neural networks have little real acceptance by industrial communities that deal with critical applications. This paper describes a technique developed for detecting combustion pressure cycle related faults in diesel engines. This method has been developed at the Pennsylvania State Universities, Applied Research Laboratories, Complex Systems Monitoring and Automation Department and applied to a fully instrumented diesel engine test bed. The new methodology utilizes pressure curve information derived from reliable and relatively inexpensive optical fiber based pressure sensors. The technique outlined in this paper uses a combination of norm based and statistical methods to develop a fault analysis map for particular internal combustion engines. A fully instrumented diesel engine test bed allows for generation of training data sets consistent with actual engine operation. Results from this technique applied to test bed data not used during development of the map show results closely match seeded fault conditions.
FPGA sensor fusion system design for IMU arrays (2018)

Different navigation systems have different requirements for attitude estimation, positioning, and control. To achieve high-accuracy at low-cost, several low-cost MEMS Inertial Measurement Units (IMU's) may be used instead of one high-performance but high-cost and power hungry mechanical IMU. The low-cost MEMS sensors require sensor fusion to aggregate several streams of low-quality sensor data into one high-quality data stream. Signal processing algorithms, such as the Kalman Filter (KF), are used to estimate and combine the output states of IMU arrays using matrix-based iterative techniques. Large IMU arrays are beneficial for estimating more than one type of physical quantities and reducing noise variance, but the underlying matrix dimensions of each KF variable increase drastically with array size. The brute force, iterative updating of these matrices using FPGAs or ASICs is not feasible due to the limitations on digital hardware resources. This paper addresses the scalability problem of IMU array sensor fusion using a specialized vector processor designed specifically to achieve real-time, high-throughput, IMU sensor array fusion based on the KF paradigm. The vector processor has been implemented in Artix-7 FPGA and shown to outperform a scalar processor by 100% in latency for a 100-component vector with the throughput being linear in the number of IMU sensors up to the limits of the FPGA resources. The tradeoffs between vector size, memory requirements, and sampling rates are also fully quantified.
Indispensable malaria genes (2018)

A critical assessment of new opportunities for drug discovery to treat malaria
Path based buffer insertion (2005)

Along with the progress of VLSI technology, buffer insertion plays an increasingly critical role on affecting circuit design and performance. Traditional buffer insertion algorithms are mostly net based and therefore often result in sub-optimal delay or unnecessary buffer expense due to the lack of global view. In this paper, we propose a novel path based buffer insertion scheme which can overcome the weakness of the net based approaches. We also discuss some potential difficulties of the path based buffer insertion approach and propose solutions to them. A fast estimation on buffered delay is employed to improve the solution quality. Gate sizing is also considered at the same time. Experimental results show that our method can efficiently reduce buffer/gate cost significantly (by 71% on average) when compared to traditional net based approaches. To the best of our knowledge, this is the first work on path based buffer insertion and simultaneous gate sizing.
Effectiveness of a blind spot visualization system with a video camera for safe lane changes (2012)

This paper proposes a new driver assistance system, named Blind Spot Visualization System, for supporting safe lane changes. This system provides the driver with the video image of the blind spots that cannot be seen easily even with the use of the side-view mirrors. An experiment with a driving simulator was conducted to compare the proposed system with a conventional system that gives a visual signal at the corresponding side view mirror when a vehicle is detected in the blind spot. The results showed that both systems were effective in improving safety and reducing driver's burden of head and eye movements for surveillance. With the proposed system, the drivers were successful in operating their car in a more stable manner. The drivers' mental workload, measured with NASA-TLX, was lower with the proposed system than with the conventional system.
Tarnishing and Restoration of Mo/Si Multilayer X-ray Mirrors (1993)

Multilayer x-ray mirrors of molybdenum and silicon operating at normal incidence at wavelengths just longward of the Si L II,III absorption edges, are a key component in the development of soft x-ray projection lithography. In this application high reflectivity is essential. Because the achievement and maintenance of high reflectivity surfaces is vital to the success of soft x-ray projection lithography, it is important to know if Mo/Si multilayers show "aging" effects, e.g. decreasing reflectivity with time. Since, in a series of measurements of such mirrors at x-ray wavelengths, we had found evidence of such decay, a series of systematic experiments was carried out.
Insect Neuropeptides (1991)

This report focuses on the identification and sequence relations of the insect neuropeptides that can trigger color changes in crustaceans, with emphasis on the newly identified family of pigment-dispersing peptides. The latter show no relation to the insect melanization and reddish coloration hormone (MRCH) and are distinct from the adipokinetic hormone (AKH) family peptides, related to the crustacean red pigment concentrating hormone (RPCH). The pigment-dispersing factors (PDFs), identified from the insects Romalea microptera and Acheta domesticus, as well as the pigment-dispersing hormones (PDHs) of Crustacea, are octadecapeptides sharing several features. The function of PDFs in insects is unknown, although immunocytochemical localization points to a neuromodulatory role. In orthopterans PDH-immunoreactive neurons are located in the optic lobes, with fiber projections into the brain as well as arborizations in the optic lobes. Enzyme-linked immunosorbant assays (ELISA) confirm the optic lobes as a rich source of immunoreactive PDF in Romalea.
Imaging the Spatio-Temporal Dynamics of Supragranular Activity in the Rat Somatosensory Cortex in Response to Stimulation of the Paws (2012)

We employed voltage-sensitive dye (VSD) imaging to investigate the spatio-temporal dynamics of the responses of the supragranular somatosensory cortex to stimulation of the four paws in urethane-anesthetized rats. We obtained the following main results. (1) Stimulation of the contralateral forepaw evoked VSD responses with greater amplitude and smaller latency than stimulation of the contralateral hindpaw, and ipsilateral VSD responses had a lower amplitude and greater latency than contralateral responses. (2) While the contralateral stimulation initially activated only one focus, the ipsilateral stimulation initially activated two foci: one focus was typically medial to the focus activated by contralateral stimulation and was stereotaxically localized in the motor cortex; the other focus was typically posterior to the focus activated by contralateral stimulation and was stereotaxically localized in the somatosensory cortex. (3) Forepaw and hindpaw somatosensory stimuli activated large areas of the sensorimotor cortex, well beyond the forepaw and hindpaw somatosensory areas of classical somatotopic maps, and forepaw stimuli activated larger cortical areas with greater activation velocity than hindpaw stimuli. (4) Stimulation of the forepaw and hindpaw evoked different cortical activation dynamics: forepaw responses displayed a clear medial directionality, whereas hindpaw responses were much more uniform in all directions. In conclusion, this work offers a complete spatio-temporal map of the supragranular VSD cortical activation in response to stimulation of the paws, showing important somatotopic differences between contralateral and ipsilateral maps as well as differences in the spatio-temporal activation dynamics in response to forepaw and hindpaw stimuli.
Microwave‐stimulated diffusion for fast processing of tissue: reduced dehydrating, clearing, and impregnating times (1986)

In this paper we describe a method of preparing tissue blocks for paraffin sections within 30 min. The method is based on microwave-stimulated diffusion reducing the dehydrating, clearing, and impregnating times by a factor of 48. The developed technique was inspired by the experimentally observed sizable temperature-dependence of viscosity and other transport properties of liquids. It is clear that, by considering the theoretical aspects of diffusion and by analysis of the influence of the used chemicals in different tissue depths, histotechnical results can be optimized. The histotechnical microwave results are light-microscopically excellent and indistinguishable from those of the well-performed 'classical' method. The nuclear size of several cell types hardly differs in both methods. The new method is valuable in particular for individual cases in which a fast diagnosis is asked for, and in which a frozen-section diagnosis is thought to be too unreliable. In addition, this method can be used in small research laboratories processing small quantities of histological material. The only equipment needed to prepare tissue blocks of optimal quality is the microwave oven.
Elevated Plasma Proinsulin/Insulin Ratio is a Marker of Reduced Insulin Secretory Capacity in Healthy Young Men (1999)

These results indicate that elevated PI/IRI ratio may serve as a marker of reduced insulin secretory function in non-diabetic subjects.
Disilylated Compounds as Precursors of Heterocycles: A New and Easy Oxadiazole Synthesis (1989)

Abstract Silyl diacylhydtazines have been synthesized. When they are treated with 3 slight amount of a uariety of catalyst (nucleophiles, F, true or Lewis acids, Pd, Pt.), 1,3,4-oxadiazoles are obtained. This cyclization can be performed in one step by using hexamethyldisilazane or dimethyldichlorosilane as the silylation agent.
Advances in Solvent‐Resistant Nanofiltration Membranes (2003)

Nanofiltration (NF) and reverse osmosis (RO) are well-established membrane technologies for applications involving aqueous streams. The principles of NF transport (diffusion, convection, and Donnan exclusion) are effectively used to develop novel membrane materials and applications in aqueous medium. Use of NF in a non-aqueous medium holds strong potential for the food, refining, and pharmaceutical industries because of the low energy costs involved with such membrane processes. Further understanding and development of solvent-resistant NF membranes provides opportunities for various hybrid processing ranging from reactor-membrane to distillation-membrane combinations. This paper provides a comprehensive overview of literature results and our own work in the area of non-aqueous systems. For solvent-based systems, potential membrane swelling and solvent-solute coupling needs to be considered for membrane design and transport theories. A simplified transport theory for pure solvents has been developed using solvent (molar volume, viscosity) and membrane properties (membrane surface energy). This model and has been verified with literature data for both hydrophilic and hydrophobic membranes. Membrane characterization and preconditioning aspects need to be given serious consideration for evaluating membrane performance. In addition to permeability and separation results, some novel applications of NF in non-aqueous solvents are included in this paper.
Modulation, Characterization, and Engineering of Advanced Materials for Electrochemical Energy Storage Applications: MoO3/V2O5 Bilayer Model System (2019)

Core–shell, multilayered and coated materials have great importance to electrochemical energy storage systems, sensors, actuators, photonics, and photoactive applications. A deeper understanding of the effect of combining different materials in complex structures on their physical and electrochemical properties is vital for better engineering of such compounds and wise modulation of their physical characteristics. Herein we proposed a model system of thin film MoO3/V2O5 bilayer systems. The crystallinity, texture, and morphology of each layer in the bilayer structures were determined by X-ray diffraction (XRD), Raman spectroscopy, high resolution scanning electron microscopy (HR-SEM), and atomic force microscopy (AFM). The electrochemical properties were studied via slow scan rate cyclic voltammetry (SSCV) in lithium ions containing solution. The study clearly shows that the physical and electrochemical properties of each layer in a bilayer configuration are not similar to the properties of the single material. Therefore, at least for bilayer materials, the whole structure properties are more complex than simply combining the properties of the individual materials.
Suicidal inactivation of cytochrome P-450 by cyclopropylamines. Evidence for cation-radical intermediates (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuicidal inactivation of cytochrome P-450 by cyclopropylamines. Evidence for cation-radical intermediatesRobert P. Hanzlik and Robert H. TullmanCite this: J. Am. Chem. Soc. 1982, 104, 7, 2048–2050Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ja00371a055https://doi.org/10.1021/ja00371a055research-articleACS PublicationsRequest reuse permissionsArticle Views229Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts