gebhart/patrepeval huggingface dataset:
Effect Of Altered Oligosaccharide Structure On The Cell Surface Number, Distribution And Turnover Of The High Molecular Weight Acidic Glycoproteins Of CHO Cells (1984)

The influence of altered carbohydrate structure on the surface number, distribution and turnover of plasma membrane glycoproteins has been studied in Chinese hamster ovary (CHO) cells by comparing three lines that are resistant to the cytotoxic effects of wheat germ agglutinin (WGA) with parental CHO cells. The glycoproteins investigated were members of a group of high molecular weight acidic glycoproteins (HMWAG). On parental cells these represent the major surface components that become labelled by lactoperoxidase-catalysed iodination. They are the only plasma membrane glycoproteins that bind WGA. The mutant lines also possess iodinatable surface polypeptides of high molecular weight, but these were less acidic and electrophoretically less diffuse than those from parental cells. These polypeptides in general did not bind [125I]WGA when two-dimensional polyacrylamide gels were overlaid with iodinated lectin. Mutant cells treated with fluorescein-conjugated WGA showed low surface fluorescence. However, the nuclear envelope and a small region in the perinuclear zone fluoresced strongly. Together, these results confirm that the surface glycoproteins of mutant cells had altered carbohydrate structure. Mouse antiserum prepared against the HMWAG, however, bound equally effectively to the mutant lines as to the parental lines. Indirect immunofluorescence experiments showed that the HMWAG had a fairly uniform distribution over the surface, and that internalization induced by second antibody occurred at a similar rate and in a similar manner in all lines, including the mutants. Electron microscopic observations using immunoperoxidase procedures confirmed the similarities in glycoprotein distribution on mutant and parental cells. Two mouse monoclonal antibodies raised against the HMWAG also revealed no difference in the number or topography of surface glycoproteins. Finally, the half-lives of several HMWAG in a parental and a mutant line (15B) maintained on low-serum medium were compared by means of a 125I/131I double-label technique. Half-lives of HMWAG from the former averaged 12 h and from the latter 11 h. It is concluded that the lack of complex termini on oligosaccharides of this particular group of CHO plasma membrane glycoproteins has no effect on their number, distribution or turnover.
Ip cisplatin in patients with malignant ascites: pharmacokinetic evaluation and comparison with the iv route. (1983)

Ip chemotherapy may be useful in managing patients with malignant ascites. This approach should result in a high concentration of drug at the site of disease, while the plasma concentration and therefore systemic toxicity remain low. Six patients with malignant ascites were treated with cisplatin at a dose of 60 mg/m2. Three patients received the drug iv; one of these patients and three other patients were treated with ip cisplatin. Platinum concentrations in plasma, ascites, protein-free ultrafiltrates of plasma and ascites, and urine were assayed by flameless atomic absorption spectrophotometry. The area under the concentration x time curve for ultrafilterable platinum in ascites was 30 times greater after ip administration of cisplatin than after iv cisplatin. Ip cisplatin can be administered safely to patients with malignant ascites and may be useful in patients with minimal residual intraperitoneal disease, particularly ovarian carcinoma.
Learning bicycle stunts (2014)

We present a general approach for simulating and controlling a human character that is riding a bicycle. The two main components of our system are offline learning and online simulation. We simulate the bicycle and the rider as an articulated rigid body system. The rider is controlled by a policy that is optimized through offline learning. We apply policy search to learn the optimal policies, which are parameterized with splines or neural networks for different bicycle maneuvers. We use Neuroevolution of Augmenting Topology (NEAT) to optimize both the parametrization and the parameters of our policies. The learned controllers are robust enough to withstand large perturbations and allow interactive user control. The rider not only learns to steer and to balance in normal riding situations, but also learns to perform a wide variety of stunts, including wheelie, endo, bunny hop, front wheel pivot and back hop.
Glycine Adjuvant Therapy to Conventional Neuroleptic Treatment in Schizophrenia (1989)

In an open-label study, glycine was administered orally (10.8 g/day in three divided doses) to six chronically psychotic patients, as an adjunct to conventional neuroleptic therapy, for periods extending from 4 days to 8 weeks. Glycine was administered in an effort to facilitate endogenous glutamatergic transmission at the level of the N-methyl-D-aspartate (NMDA) receptor complex, since a glutamatergic deficiency in the pathophysiology of schizophrenia has been postulated. Therapeutic efficacy was assessed with standardized psychiatric rating scales. Beneficial effects on behavioral symptomatology were observed in two patients, whereas two others worsened. In one of the two responders, clinical deterioration occurred after glycine withdrawal consistent with a positive adjuvant effect in this patient. However, glycine rechallenge in this patient was not associated with the clinical improvement seen during the initial glycine period. Clinical worsening was not observed after glycine discontinuation in the second responder. Glycine administration reduced neuroleptic-induced muscle stiffness and extrapyramidal dysfunction in three of the six patients. All patients tolerated the clinical trial. The limited penetrability of glycine across the blood-brain barrier is a major limitation of this approach to facilitating glutamatergic transmission at the level of the NMDA receptor complex.
Status of Equation of State Project at the NETL (2014)

Abstract We describe a collaborative effort to accelerate the development of Equation of State (EoS) models to predict density and viscosity of crude oils at temperatures up to 533 K and pressures up to 276 MPa. These conditions are consistent with reservoirs encountered in ultra-deep formations such as in the Gulf of Mexico. The collaboration is organized by the U.S. Department of Energy-National Energy Technology Laboratory and two universities (University of Pittsburgh and Virginia Commonwealth University). This is being done by conducting well-defined validation experiments and by developing cubic and SAFT-based mathematical expressions for density and viscosity. The net result of this effort will be a suite of validated equations of state for crude oil at high temperature and high pressure conditions, and the widespread usage of these equations in reservoir simulators. Such reservoir models are critical not only to assess the magnitude of oil spills associated with failures in the wells or of production equipment but also to develop the appropriate response strategies should such accidents occur.
Exuberant Verbosity (1913)

<h3>To the Editor:</h3> —Has the editorial writer (The Journal, Oct. 18, 1913, p. 1464) overlooked the historical fact that the exuberant verbosity of legal forms was not an intoxication, but a species of graft? Old English law-clerks were paid so much a word or a line for engrossing legal documents, and in consequence the more words used, the greater the pay. Every synonym, nearly or distantly connected, was drawn in and duly inscribed. A sentence lingers in my memory, taken from an old English common-law form of indictment for maintaining a nuisance in which it is alleged that "divers odors, savors, smells, scents and stenches did issue, proceed and flow therefrom." As the principles of<i>lex scripta</i>are said to be immutable, so also appears to be its language; for the same quaint, archaic phraseology, scarcely altered except in spelling, is used in legal forms to-day as in the days
Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review) (2014)

Under conditions of acute stress, rapid adaptation is crucial for maximizing biological survival. The responses to environmental stress are often complex, involving numerous genes and integrating events at the cellular and organismal levels. The heat shock proteins (HSPs) are a family of highly conserved proteins that play critical roles in maintaining cell homeostasis and protecting cells under chronic and acute stress conditions. The genes for these stress-responding proteins are widely distributed in organisms, tissues and cells. HSPs participate in a variety of physiological processes and are associated with various types of disease. In this review, we focused on family with sequence similarity 107 (FAM107), a novel unique protein family that exhibits functional similarity with HSPs during the cellular stress response. This review aimed to summarize the biological properties of FAM107 in cancer and the nervous system.
Intelligent handling of communication media (2002)

Personal communication support enhances control over reachability in telecommunication. Conversion and screening technologies of communication media, combined with QoS evaluation, allow to focus on the semantics of the information instead of the carriage. The paper considers how a CORBA-based implementation allows scaling from Java clients to IN service nodes and TINA integration.
Antimicrobial proteins and polypeptides in pulmonary innate defence (2006)

Inspired air contains a myriad of potential pathogens, pollutants and inflammatory stimuli. In the normal lung, these pathogens are rarely problematic. This is because the epithelial lining fluid in the lung is rich in many innate immunity proteins and peptides that provide a powerful anti-microbial screen. These defensive proteins have anti-bacterial, anti- viral and in some cases, even anti-fungal properties. Their antimicrobial effects are as diverse as inhibition of biofilm formation and prevention of viral replication. The innate immunity proteins and peptides also play key immunomodulatory roles. They are involved in many key processes such as opsonisation facilitating phagocytosis of bacteria and viruses by macrophages and monocytes. They act as important mediators in inflammatory pathways and are capable of binding bacterial endotoxins and CPG motifs. They can also influence expression of adhesion molecules as well as acting as powerful anti-oxidants and anti-proteases. Exciting new antimicrobial and immunomodulatory functions are being elucidated for existing proteins that were previously thought to be of lesser importance. The potential therapeutic applications of these proteins and peptides in combating infection and preventing inflammation are the subject of ongoing research that holds much promise for the future.
Intracranial Metastasis From Synovial Sarcoma (2008)

Synovial sarcomas comprise between 5% to 10% of all soft tissue sarcomas in adults. It has a predilection for young adults and is one of the more frequently misdiagnosed soft tissue sarcomas. It is not unusual for synovial sarcoma to present initially after a traumatic event. It most commonly occurs in close proximity to a large joint. The most common site for metastasis is the lung, followed by lymph node involvement. Synovial sarcoma rarely metastasizes to the skeleton and when it occurs, it most commonly involves the long bones. Cranial metastasis is rare and has only been described in 2 previously reported cases. Reports of other sarcomas having intracranial metastasis include rhabdomyosarcoma, angiosarcoma, fibrosarcoma, liposarcoma, Ewing's sarcoma, and clear cell sarcoma from the kidney. The synchronous or metachronous development of >or=2 primary soft tissue sarcomas has been reported. These are primary soft tissue sarcomas occurring at multiple soft tissue sites without pulmonary or lymphatic involvement. It is often difficult to distinguish between the synchronous or metachronous appearance of a second primary and soft tissue sarcoma metastasis. This article presents a case of a 17-year-old adolescent boy who presented with simultaneous enlarging masses involving the skull and thigh. Open biopsies confirmed synovial sarcoma in both regions. Staging studies, including computed tomography (CT) of his chest, abdomen/pelvis and bone scan were otherwise negative for metastasis.
Enhancement of cisplatin sensitivity of quiescent cells in solid tumors by combined treatment with tirapazamine and low-temperature hyperthermia. (1999)

We examined the enhanced chemosensitivity of quiescent (Q) cells in solid tumors to cis-diamminedichloroplatinum (II) (cisplatin) by combined treatment with tirapazamine (TPZ) and mild heating. C3H/He and Balb/c mice bearing SCC VII and EMT6/KU tumors, respectively, received continuous administration of 5-bromo-2'-deoxyuridine (BrdU) for 5 days using implanted mini-osmotic pumps to label all proliferating (P) cells. TPZ was administered intraperitoneally 2 h before cisplatin injection and/or tumors were locally heated at 40 degrees C for 60 min immediately after cisplatin injection. Sixty minutes after cisplatin injection, the tumors were excised, minced and trypsinized. The tumor cell suspensions were incubated with cytochalasin-B (a cytokinesis blocker), and the micronucleus (MN) frequency in cells without BrdU labeling (= Q cells) was determined using immunofluorescence staining for BrdU. The MN frequency in total (P+Q) tumor cells was determined from the tumors that were not pretreated with BrdU. The sensitivity to cisplatin was evaluated in terms of the frequency of induced micronuclei in binuclear tumor cells (MN frequency). Other groups of tumor-bearing C3H/He and Balb/c mice not given BrdU were injected with 195mPt-radiolabeled cisplatin. In both tumor systems, the MN frequency in Q cells was lower than that in the total cells. TPZ and mild heat treatment elevated the MN frequency in total and Q cells in both tumor systems, and to a higher extent in Q cells. The combination of TPZ and mild heat treatment increased the MN frequency more markedly than treatment with either TPZ or mild heating alone. In total tumor cells, TPZ and mild heat treatment increased the MN frequency in EMT6/KU tumor cells more markedly than in SCC VII tumor cells. 195mPt-labeled cisplatin uptake into total tumor cells was increased by mild heat treatment but not by TPZ. The cisplatin-sensitivity of Q cells was lower than that of total cells in both tumor systems. TPZ was thought to sensitize Q cells by killing the hypoxic cells without influencing tumor blood flow, and mild hyperthermia appeared to sensitize Q cells by distributing more cisplatin with an increase in blood flow in solid tumors.
Generalizing Image Captions for Image-Text Parallel Corpus (2013)

The ever growing amount of web images and their associated texts offers new opportunities for integrative models bridging natural language processing and computer vision. However, the potential benefits of such data are yet to be fully realized due to the complexity and noise in the alignment between image content and text. We address this challenge with contributions in two folds: first, we introduce the new task of image caption generalization, formulated as visually-guided sentence compression, and present an efficient algorithm based on dynamic beam search with dependency-based constraints. Second, we release a new large-scale corpus with 1 million image-caption pairs achieving tighter content alignment between images and text. Evaluation results show the intrinsic quality of the generalized captions and the extrinsic utility of the new imagetext parallel corpus with respect to a concrete application of image caption transfer. 1
Novel Carbon-Cage-Based Ultralow-$k$ Materials: Modeling and First Experiments (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A new class of materials is presented that is supposed to be a potential candidate for isolating ultra low-k thin films between metal on-chip interconnects in future CMOS technology nodes. The ideal structure of the novel carbon-cage-based materials is described by a model that assumes an ordered network (mosaic structure) with fullerenes (C60) as the nodes and linker molecules along the edges of the mosaic cells. The interior of the network represents a nanopore of a 1-nm scale. According to the molecular design-based model, structures with simple cubic and diamond-like topology of the network are considered promising candidates. A dielectric constant (k value) of 1.7 and an elastic bulk modulus of about 20 GPa are predicted of ideal combinations of network topology and linker molecules. First experimental results, based on electron energy loss spectroscopy, X-ray absorption spectroscopy, nanoindentation, and atomic force microscopy are presented. A more controlled film fabrication process is needed to get more homogeneous thin films with characteristic material parameters as predicted by the model. </para>
Automatic Critical Mechanic Discovery in Video Games. (2019)

We present a new method of automatic critical mechanic discovery for video games using a combination of game description parsing and playtrace information. This method is applied to several games within the General Video Game Artificial Intelligence (GVG-AI) framework. In a user study, human-identified mechanics are compared against system-identified critical mechanics to verify alignment between humans and the system. The results of the study demonstrate that the new method is able to match humans with higher consistency than baseline. Our system is further validated by comparing MCTS agents augmented with critical mechanics and vanilla MCTS agents on 4 games from GVG-AI. Our new playtrace method shows a significant performance improvement over the baseline for all 4 tested games. The proposed method also shows either matched or improved performance over the old method, demonstrating that playtrace information is responsible for more complete critical mechanic discovery.
Jitterbug spin channel mixing in heterogeneous giant magnetoresistive material (1996)

A mechanism is described which considers the effect of small magnetic particles on the spin diffusion length in a granular giant magnetoresistive material. Spin depolarization occurs by precession of the spin orientation of the carrier due to the s–d exchange interaction within a magnetic particle. Numerical simulation of this jitterbug effect is found to generate a temperature and field dependence of the distance a carrier may travel within the sample without losing its spin memory.
Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: regional experience and high incidence of carnitine deficiency (2013)

Our data show a direct association between homozygosity for c.985A>G and lower carnitine values at diagnosis, and a higher dose of carnitine supplementation for maintenance within the normal range. This study contributes to a better understanding of the relationship between genotype and phenotype in newborn patients with MCADD detected through screening which could be useful in improving follow-up strategies and clinical outcome.
Correlation between self-reported cocaine use and urine toxicology in an inner-city prenatal population. (1997)

To determine the prevalence of recent cocaine use and the accuracy of self-reported use, the results of a urine assay for the major cocaine metabolite benzoylecgonine were compared with self-reported cocaine use in an inner-city prenatal population offered routine voluntary urine toxicology screening at the time of registration for prenatal care. During a 1-year period, 6866 women registered for prenatal care and 5200 (76%) consented to urine assays for cocaine metabolites. Of the women consenting to urine assays, 253 (5%) had positive assays for benzoylecgonine. Women with positive assays were significantly more likely than those with negative assays to be older (mean [SD] 27 [5] versus 23 [6] years), black, single, and unemployed. In addition, women with positive assays were significantly more likely to be multiparous, report > two sexual partners in the previous year, and acknowledge a history of a sexually transmitted disease (STD). Forty-seven percent of women with positive assays acknowledged cocaine use in the 6 months prior to sampling. Women with positive assays who denied cocaine use were significantly more likely than those who admitted use to be younger (mean [SD] 26 [5] versus 28 [4] years), to report > or = two sexual partners in the past year, and acknowledge a history of an STD. This analysis revealed a poor correlation between self-reported cocaine use and the results of urine assays for cocaine metabolites among women seeking prenatal care in an inner-city institution.
Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions (1985)

The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.
Incorporating Industry Based Research Into An Undergraduate Course (2020)

There are many benefits associated with including industry-based research into an undergraduate engineering curriculum, but often academic and industry participants have different perspectives on project deliverables. This paper features a case study where senior-level students collect and analyze data in a retail environment, develop conclusions and recommendations for the organization, and present their findings to corporate executives. The paper discusses what techniques worked well for all involved parties, as well as. what changes should be made to make the learning experience more productive.
Identification of Hydroperoxy Species as Reaction Intermediates in the Electrochemical Evolution of Oxygen on Gold (2010)

Gotcha! Using electrochemical surface-enhanced Raman spectroscopy, surface-bound hydroxyperoxy (AuOOH) is pinpointed in situ as a reaction intermediate of oxygen evolution on gold catalyst (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.