gebhart/patrepeval huggingface dataset:
The General Kinetics of Co-Polymerization and an Extension of the Viscosity Method to Determine Velocity Constants (1949)

Completely general kinetic expressions have been developed for the co-polymerization of n monomers, assuming that the reactivities of the radicals depend only on their terminal groups. Allowance has been made for chain transfer and the fact that thermal and photo-chemical initiation may proceed via diradicals. The equations are of the same form as those developed previously for a simple polymerization. The latter appear as a special case in which n=1. It is pointed out that the method previously developed for determining the velocity constants in simple polymerizations can be used without modification in the study of co-polymerizations. In this way 12 of the 14 velocity constants in a binary co-polymerization can be determined absolutely, and a relation between the remaining two obtained.
Oxygen Diffusion through Natural Extracellular Matrices: Implications for Estimating “Critical Thickness” Values in Tendon Tissue Engineering (2008)

Oxygen is necessary for maintaining cell proliferation and viability and extracellular matrix (ECM) production in 3-dimensional tissue engineering. Typically, diffusion is the primary mode for oxygen transport in vitro; thus, ensuring an adequate oxygen supply is essential. In this study, we determined the oxygen diffusion coefficients of 3 natural ECMs that are being investigated as construct scaffolds for tendon tissue engineering: small-intestine submucosa (SIS), human dermis (Alloderm), and canine fascia lata. Diffusion coefficients were determined using a standard diffusion cell system. The ranges for each matrix type were: SIS: 7 x 10(-6) - 2 x 10(-5) cm2/s, Alloderm: 1.9 - 3.1 x 10(-5) cm2/s, and canine fascia lata: 1.6 - 4 x 10(-5) cm2/s. We used the experimental oxygen diffusivity data for these natural ECMs in a mathematical model of oxygen diffusion through a cell-seeded scaffold to estimate the critical size of cell-seeded scaffold that can be cultured in vitro.
Artificial-Intelligence-Enabled Air Interface for 6G: Solutions, Challenges, and Standardization Impacts (2020)

As 3GPP has completed Release 16 specifications and worldwide 5G commercialization is speeding up, global interest in 6G is starting to grow. An interesting and important question is: will the rapid progress in artificial intelligence (AI) eventually alleviate the tremendous efforts required for future standardization of 6G and beyond? In this article, the potential impacts of AI on the air interface design and standardization are investigated. The AI-enabled network architecture is first discussed. The higher layer, physical layer, and cross-layer design empowered by AI capability are further presented. Based on these designs, the future 6G and beyond are expected to enter into an AI era. For potential new use cases and more challenging requirements, the network is capable of automatic updating the air interface protocols, which may substantially reduce the standardization efforts and costs of wireless communication networks.
Improving Lemmatization of Non-Standard Languages with Joint Learning (2019)

Enrique Manjavacas, Ákos Kádár, Mike Kestemont. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Administration and monitoring of intravenous anesthetics (2010)

Anesthetic drug administration might be optimized by applying knowledge from clinical pharmacokinetics and dynamics.
Cell Cycle Dependence of Ionizing Radiation-Induced DNA Deletions and Antioxidant Radioprotection inSaccharomyces cerevisiae (2010)

The yeast DEL assay is an effective method for measuring intrachromosomal recombination events resulting in DNA deletions that when occurring in mammalian cells are often associated with genomic instability and carcinogenesis. Here we used the DEL assay to measure gamma-ray-induced DNA deletions throughout different phases of yeast culture growth. Whereas yeast survival differed by only up to twofold throughout the yeast growth phase, proliferating cells in lag and early exponential growth phases were tenfold more sensitive to ionizing radiation-induced DNA deletions than cells in stationary phase. Radiation-induced DNA deletion potential was found to correlate directly with the fraction of cells in S/G(2) phase. The ability of the antioxidants l-ascorbic acid and DMSO to protect against radiation-induced DNA deletions was also measured within the different phases of yeast culture growth. Yeast cells in lag and early exponential growth phases were uniquely protected by antioxidant treatment, whereas nondividing cells in stationary phase could not be protected against the induction of DNA deletions. These results are compared with those from mammalian cell studies, and the implications for radiation-induced carcinogenesis and radioprotection are discussed.
بررسی مقایسهای میزان پوشش ریشه با استفاده از روش فلپ هلالی جابهجا شونده تاجی با و بدون استفاده از محلول تتراسایکلین موضعی (2008)

Introduction : Treatment of gingival recession has been one of the most important aims of periodontalprocedures and therefore introduction of a predictable technique for covering the denuded roots hasbeen an ideal goal for many years.The purpose of this study was the evaluation of root coverage by ;Semilunar coronally repositionedflap; technique; and the role of topical application of tetracycline hydrochloride in improvement of theresults. Methods and Materials : 24 anterior and premolar teeth were selected from 9 patients and dividedrandomly in two ;test and control; groups. After completion of initial procedure and before operation,some quantitative (Vertical recession, depth of gingival sulcus and width of keratinized gingiva), andqualitative variables (Sensitivity of root surface to air flow and feeling of an unsatisfactory appearanceby the patient oneself) were measured.In test group, tetracycline 1% (pH = 2.3) was applied 3 minutes by burnishing method on the surfaceof root, before performance of surgery.The patients were visited at the days 7, 14, 30, and 90 after the operation, and healing of the area andhygiene status were evaluated. Results : Following statistical analysis, it was concluded that recession depth has been reducedsignificantly in both groups, 1 and 3 months after the operation.• The mean root coverage in test group was 2.29 mm (70.33% coverage), and 2.16 mm (67.33%coverage), 1 and 3 months after surgery, respectively.• Width of keratinized tissue was also increased significantly in both groups.• Among the quantitative variables, only probing depth did not alter during the period of research.• Qualitative variables were also improved significantly in both groups.• Apparently, the application of solution as a ;root conditioning agent; did not influence the results ofthis study. Conclusion : In summary, the operation technique may be an appropriate procedure for the coverageof the anterior teeth in maxilla, based on its unique advantages. Key words : Gingival recession, Root coverage, Semilunar coronally repositioned flap, Topical tetracycline,Root sensitivity, Keratinized gingiva.
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777 (2009)

GMX1778 was recently shown to function as a potent inhibitor of nicotinamide phosphoribosyl transferase. To translate the discovery of GMX1778 mechanism of action into optimal clinical use of its intravenously administered prodrug, GMX1777, the efficacy of GMX1777 was evaluated in xenograft models and the pharmacokinetic profile of GMX1778 and its effect on nicotinamide adenine dinucleotide cellular levels was measured by liquid chromatography/mass spectrometry. Consistent with the requirement for a prolonged exposure for cytotoxicity in vitro, a dose of 75 mg/kg of GMX1777 administered as two bolus intravenous injections in 1 day were not effective at reducing the growth of multiple myeloma (IM-9) tumors, whereas the same dose of GMX1777 administered over a 24 h intravenous infusion caused tumor regression in the IM-9 model, a small-cell lung cancer (SHP-77) model, and a colon carcinoma (HCT-116) model. A 72 h continuous intravenous infusion of GMX1777 was also effective in the IM-9 model, but was associated with a smaller therapeutic index. GMX1777 at a dose of 75 mg/kg administered over a 24 h intravenous infusion produced GMX1778 steady-state plasma levels of approximately 1 microg/ml and caused nicotinamide adenine dinucleotide levels to decrease significantly in tumors. Consistent with the GMX1778 mechanism of action, nicotinic acid protected mice treated with a lethal dose of GMX1777. These data support the design of an open-label, dose-escalation trial, in which patients with refractory solid tumors and lymphomas receive 24 h infusions of GMX1777 as a single agent in 3-week cycles. Furthermore, these results indicate that nicotinic acid is a potent antidote to treat GMX1777 overdose.
32.4: A Lightweight 3‐D HMD with Accommodative Compensation (1998)

Abstract This paper describes the development of the 3DDAC mk. 4 system, a brand new implementation in our research program. The 3DDAC is a fatigueless stereoscopic display system with a compensating function of accommodation for binocular disparity 3‐D image representation. The mk. 4 system is a lightweight HMD style.
Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells (2021)

Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules of cytotoxic cells, and have predominantly been studied for their pro-apoptotic role upon delivery in target cells. A growing body of evidence is emerging that granzymes also display extracellular functions, which largely remain unknown. In the present study, we show that extracellular granzyme K (GrK) inhibits angiogenesis and triggers endothelial cells to release soluble VEGFR1 (sVEGFR1), a decoy receptor that inhibits angiogenesis by sequestering VEGF-A. GrK does not cleave off membrane-bound VEGFR1 from the cell surface, does not release potential sVEGFR1 storage pools from endothelial cells, and does not trigger sVEGFR1 release <i>via</i> protease activating receptor-1 (PAR-1) activation. GrK induces <i>de novo</i> sVEGFR1 mRNA and protein expression and subsequent release of sVEGFR1 from endothelial cells. GrK protein is detectable in human colorectal tumor tissue and its levels positively correlate with sVEGFR1 protein levels and negatively correlate with T4 intratumoral angiogenesis and tumor size. In conclusion, extracellular GrK can inhibit angiogenesis <i>via</i> secretion of sVEGFR1 from endothelial cells, thereby sequestering VEGF-A and impairing VEGFR signaling. Our observation that GrK positively correlates with sVEGFR1 and negatively correlates with angiogenesis in colorectal cancer, suggest that the GrK-sVEGFR1-angiogenesis axis may be a valid target for development of novel anti-angiogenic therapies in cancer.
A Fully-Differential Delay-Line Based Control for Resonant Switched-Capacitor Converter (2022)

This paper presents a new control method to regulate the output current of a resonant switched-capacitor converter (ReSCC). Starting from a fixed switching frequency operation, the phase-shift required to regulate the average output current is modulated through a fully-differential control scheme composed by a fully-differential OTA, a differential compensation network and two identical voltage-controlled delay lines. The proposed method eliminates any restriction on the minimum achievable phase-shift, is suitable for integration in a scaled technology and for high-frequency operation. Moreover, it allows a seamless control between output current sourcing and sinking capabilities, extending the load current range, and improving the response to load transients. A circuit design has been performed on a 110-nm BCD technology, with 3.7 V to 1.8 V voltage conversion, 60 mA of output current and 10 MHz operation. Simulations demonstrate the effectiveness of the proposed method.
An Antifungal Polyacetylenic Compound from the Culture Filtrate of the Fungus Trametes pubescens (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Antifungal Polyacetylenic Compound from the Culture Filtrate of the Fungus Trametes pubescensErmias Dagne, Senait Asmellash, and Dawit AbateCite this: J. Nat. Prod. 1994, 57, 3, 390–392Publication Date (Print):March 1, 1994Publication History Published online1 July 2004Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/np50105a010https://doi.org/10.1021/np50105a010research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cosmology with the SPHEREX All-Sky Spectral Survey (2014)

SPHEREx (Spectro-Photometer for the History of the Universe, Epoch of Reionization, and Ices Explorer) ( http://spherex.caltech.edu ) is a proposed all-sky spectroscopic survey satellite designed to address all three science goals in NASA's Astrophysics Division: probe the origin and destiny of our Universe; explore whether planets around other stars could harbor life; and explore the origin and evolution of galaxies. SPHEREx will scan a series of Linear Variable Filters systematically across the entire sky. The SPHEREx data set will contain R=40 spectra fir 0.75$
ME-11 * REDUCTION OF NFkB IN THE IN THE TUMOR MICROENVIRONMENT ALTERS THE NEURAL EXTRACELLULAR MATRIX AND REDUCES GLIOBLASTOMA GROWTH AND DISPERSION (2014)

Identifying major support mechanisms in the neural microenvironment could have significant impact against growth and invasion of malignant gliomas. The NFkB pathway is a major signaling hub that drives tumor progression and at the same time regulates the inflammatory responses of normal tissues. Here we show that animals with a stunted NFkB response exhibit reduced reactivity against intracranial gliomas, which surprisingly reduces tumor growth and invasion. NFkB-deficient mice (RelA + /- TNFR1-/-) were injected intracranially with mouse GL261 glioblastoma cells to analyze tumor phenotype. Histological and MRI analyses showed significantly smaller tumors in RelA + /- mice compared to control littermates. Interestingly, immunohistochemical studies indicated that tumors in RelA + /- mice had vascularization and infiltration of microglia/macrophages comparable to controls, but significant reduction of M2 microglia/macrophage polarization and GFAP-positive astroglia. The lower reactivity of RelA + /- astroglia was also evident following intracranial implantation of highly invasive mouse glioblastoma cells (Mut4; GFAP-Cre:Nf1loxP/+ Trp53-/+ PTENloxP/+), suggesting that the astrocyte compartment played a major role in tumor growth or invasion. To test this hypothesis we prepared cultures of brain slices, where astrocytes and their secreted ECM are the major components challenging glioma cells. Interestingly, glioblastoma cells were significantly less invasive in brain slices from NFkB-deficient mice compared to wild-type tissue. Further analysis of RelA-/–astrocytes demonstrated reduced migration towards glioblastoma cells, increased expression of neural chondroitin sulfate proteoglycans and reduced expression of the metalloproteases that cleave these inhibitory ECM proteins, lending support to the reduced tumor progression observed in vivo. Taken together, these results strongly suggest that activation of NFkB in the neural microenvironment underlies the reactive glial response that promotes tumor growth and invasion. In particular, our results highlight astroglial NFkB signaling as a driver of glioma malignancy that should be considered for long-term targeted strategies.
Catalytic enantioselective aryl transfer: asymmetric addition of diphenylzinc to aldehydes (1999)

C. Bolm and K. Muñiz, Chem. Commun., 1999, 1295 DOI: 10.1039/A903884A
A retailers way into 3D (2013)

Technical leaders from IKEA Communications AB in Sweden will present the challenge for a retailer to take on photographic renderings of indoor homes for Catalog and Web. We will share the progress from the first stumbling steps of creating product images to large volumes of full room sets that is used alongside traditionally created studio photos for the catalog and on the web.
ChemInform Abstract: A High‐Pressure Single‐Crystal Synchrotron Diffraction Study of NH4RbTe4O9·2H2O: Stability of Three Different TeOx Coordination Polyhedra. (2012)

Abstract The crystal structure of the title compound is determined as a function of pressure up to 7.40 GPa based on synchrotron single crystal XRD data.
Variant- and strain-specific immunity in Saimiri infected with Plasmodium falciparum. (1998)

Variant- and strain-specific immunity to malaria in Saimiri monkeys infected with homologous O and R variants of the Palo Alto strain (FUPSP) of Plasmodium falciparum or by various heterologous divergent strains were studied. Following homologous reinfections, the primary immune response in monkeys was effective only against the same variant type but not against the other variant, which differed only by antigens exposed at the surface of the infected red blood cell. In contrast, after two successive inoculations with a single variant type, a variant transcending immunity developed to both O and R parasite populations. The immunity against FUPSP in monkeys repeatedly infected with various combinations of heterologous strains, including Sal I, Tanzania, Camp, FUPCP, FCH4, FVO, and FUPCDC parasites was less effective, resulting at best in protecting the monkey against fulminating infection. However, in several cases, previous or concomitant heterologous infections modified the course of virulent infection by FUPSP parasites, indicating a significant degree of cross-protection between the strains. Therefore, in this model, while variant- and strain-specific antigens are important components of acquired immunity to malaria, the monkey immune response to infection transcends phenotypic antigenic variation and strain diversity.
Comparison of the Efficacy of Local Therapies for Localized Prostate Cancer in the Prostate-Specific Antigen Era: A Large Single-Institution Experience With Radical Prostatectomy and External-Beam Radiotherapy (2002)

Eight-year biochemical failure rates were identical between RT and RP in any subgroup. Outcome is determined mainly by pretreatment PSA levels, bGS, clinical T stage, and, for RT patients, radiation dose.
Towards Multi-Perspective Intelligent Layout Design for Context-Driven Route Navigation (2008)

With the growing research interest in intelligent pervasive environments, there is a need to plan our layouts with sufficient criteria modelling so as to provide support for context-driven route navigation. However, current spatial layout modelling and simulation tools are largely inadequate for the task required since they are based on manual and heuristic techniques and do not provide a rich resource of context that will very well reflect user-perceived models of a layout. In this paper, we present an initial proof of concept prototype of a multi-perspective intelligent layout design and analysis framework to support context-driven navigation. We aim to show that some of the ideas to emerge from the field of intelligent systems, HCI, semantic technologies and advanced simulation could be combined with novel techniques in GIS-based information and image processing to analyse and visualise traffic networks and layouts from a range of design, travel and user-related perspectives.
Rotary Multilayer Split Morph–A Piezoelectric Microactuator for Dual-Stage Actuation Systems in High Track Density Hard Disk Drives (2001)

A novel annular rotary piezoelectric microactuator has been proposed for a dual-stage actuation system for future high track density hard disk drives. The microactuator is designed to be mounted on a flexure tongue and drives a slider directly to perform high-frequency track following. The configuration and operation of the microactuator are described. The controllable stroke and the resonance frequency of the slider/actuator assembly have been evaluated and optimized by finite-element analysis. The results reveal that the designed actuator/slider assembly should be a promising addition to the dual-stage actuation system.
Contour mapping of Europa using frequency diverse spatial heterodyne imaging (2006)

Three dimensional imaging of planetary and lunar surfaces has traditionally been the purview of Synthetic Aperture Radar payloads. We propose an active imaging technique that utilizes laser frequency diversity coupled with spatial heterodyne imaging. Spatial heterodyne imaging makes use of a local oscillator which encodes pupil plane object information on a carrier frequency. The object information is extracted via Fourier analysis. Snapshots of the encoded pupil plane information are acquired as the frequency of the illumination laser is varied in small steps (GHz). The resulting three-dimensional data cube is processed to provide angle-angle-range information. The range resolution can be adjusted from microns to meters simply by adjusting the range over which the illuminator laser frequency is varied. The proposed technique can provide fine resolution contour maps of planetary surfaces having widely varying characteristics of importance to science exploration, such as the search for astrobiological habitat niches near the surface of heavily irradiated Europa. This information can be used to better understand the geological processes that form the surface features, and help characterize candidate potential habitat sites on the surface of Europa and other planetary bodies of interest. In this paper we present simulations and experimental data that demonstrate the concept.
ChemInform Abstract: SYNTH. UND EIGENSCHAFTEN VON KOBALTKOMPLEXEN MIT ZWEIWERTIGEM PI‐GEBUNDENEM C2B8H10(4‐)‐LIGANDEN (1971)

Abstract Ausführliche Beschreibung der Darstellung der bereits früher synthetisierten und kristallographisch charakterisierten Komplexe: (III) und (IV).