gebhart/patrepeval huggingface dataset:
Thyroglobulin Messenger RNA: Translation of a 33‐S mRNA into a Peptide Immunologically Related to Thyroglobulin (1975)

Poly(UC)--Sepharose chromatography of the RNA extracted from a thyroid fraction sedimenting between 800 X g and 27000 X g allows the purification of two RNA fractions amounting each to 1% of the applied material. The first one is loosely bound to the column from which it is eluted at 25 degrees C. It is mainly composed of 16-S and 12-S RNA comprising no poly(A) sequences. This could correspond to mitochondrial rRNA. The second one, which is eluted at 50 degrees C, is poly(A)-rich and represents 33-S and 17--18-S RNA species. The 33-S RNA resists heating at 80 degrees C, suggesting that it is composed of one polynucleotide chain. When injected into Xenopus oocytes, the 33-S RNA specifically promotes the synthesis of a peptide with an apparent molecular weight of 185000 and an apparent sedimentation coefficient of 10-S. This peptide is immunologically related to thyroglobulin and could represent its main precursor. Under the conditions tested it does not polymerize spontaneously into 19-S thyroglobulin, suggesting that assembly of the molecule could require specific, post-translational alterations of the precursor and/or the presence of additional lighter subunits.
A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system (2008)

Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis-regulatory modules in a genome. The primary limitation for this type of analysis is the paucity of specificity data that is available for the majority of TFs. We describe an omega-based bacterial one-hybrid system that provides a rapid method for characterizing DNA-binding specificities on a genome-wide scale. Using this system, 35 members of the Drosophila melanogaster segmentation network have been characterized, including representative members of all of the major classes of DNA-binding domains. A suite of web-based tools was created that uses this binding site dataset and phylogenetic comparisons to identify cis-regulatory modules throughout the fly genome. These tools allow specificities for any combination of factors to be used to perform rapid local or genome-wide searches for cis-regulatory modules. The utility of these factor specificities and tools is demonstrated on the well-characterized segmentation network. By incorporating specificity data on an additional 66 factors that we have characterized, our tools utilize approximately 14% of the predicted factors within the fly genome and provide an important new community resource for the identification of cis-regulatory modules.
Oxygen-Copper (II) Interplay in the Repair of Semi-Oxidized Urate by Quercetin Bound to Human Serum Albumin (2004)

The 1:1 complex of copper (II) and human serum albumin (HSA) slowly reacts with radiolytically generated *O2- radical-anion at a rate constant of 6.1 x 10(6) M(-1) s(-1). Absorbance and fluorescence spectroscopies demonstrate that addition of an equimolar portion of quercetin (QH2) to the solution of the copper (II)-HSA complex induces a relocalization of the copper resulting in a ternary copper (II)-QH2-HSA complex. This form of quercetin slowly oxidizes in air-saturated solutions. A 10-fold excess urate, a plasma antioxidant, cannot displace copper (II) bound to HSA. In N2O-saturated solutions the ternary complex form of QH2 can repair the urate radical with a rate constant of 2.7 x 10(6) M(-1) s(-1) by an electron transfer reaction similar to that observed in the absence of copper (II). In O2-saturated solutions and in the absence of copper, HSA-bound QH2 fails to repair the urate radical because of the fast competitive reaction of *O2- with urate radicals. However, addition of equimolar copper (II) restores the electron transfer from QH2 to the urate radical. These contrasting results are tentatively explained either by an enhanced reactivity of copper (II) with *O2- in the ternary complex or by direct production of quercetin radicals via a copper-catalyzed reduction of the *O2- radicals by QH2.
Dietary Intervention with Cooking Instructions and Self-monitoring of the Diet in Free-Living Hypertensive Men (2012)

The control of blood pressure (BP) is important in the prevention of cardiovascular diseases. This study was conducted to evaluate the effect of a dietary educational program for free-living, high-normal, and stage 1 or 2 hypertensive men. The participants were volunteers aged 40-75 years who agreed to the intervention. They were divided into two groups: 39 men for the intervention group and 32 men for the control group. BP, urinary sodium and potassium excretion, dietary and lifestyle data, and nonfasting venous blood sample were collected at baseline and after the intervention period. The intervention was designed to decrease sodium level with an emphasis on a decrease in the consumption of salted foods and to increase potassium level with an emphasis on an increase in the consumption of fruit and vegetables through cooking instructions and self-monitoring of the diet. At the baseline, there were no significant differences observed between the groups, except the diastolic BP. In the intervention group, a greater decrease in the urinary sodium-to-potassium excretion ratio was observed, compared with the control group (net difference 0.6, P = .029). The systolic and diastolic BP (mm Hg) decreased in the intervention group (149.0-143.0, P = .073; 93.0-87.0, P = .002), but no changes were observed in the control group (145.0-143.0, P = .231; 84.9-85.3, P = .381). In the intervention group, the urinary sodium-to-potassium excretion ratio was significantly improved by focusing on cooking instructions and self-monitoring of the diet.
Quantitative Inspection of Remanence of Broken Wire Rope Based on Compressed Sensing (2016)

Most traditional strong magnetic inspection equipment has disadvantages such as big excitation devices, high weight, low detection precision, and inconvenient operation. This paper presents the design of a giant magneto-resistance (GMR) sensor array collection system. The remanence signal is collected to acquire two-dimensional magnetic flux leakage (MFL) data on the surface of wire ropes. Through the use of compressed sensing wavelet filtering (CSWF), the image expression of wire ropes MFL on the surface was obtained. Then this was taken as the input of the designed back propagation (BP) neural network to extract three kinds of MFL image geometry features and seven invariant moments of defect images. Good results were obtained. The experimental results show that nondestructive inspection through the use of remanence has higher accuracy and reliability compared with traditional inspection devices, along with smaller volume, lighter weight and higher precision.
Vanadium Compounds (1998)

This chapter summarizes the aqueous chemistry of vanadium in oxidation states III, IV and V and briefly describes chemistry in nonaqueous solutions. Although this chapter focuses on vanadium chemistry, it serves as an introduction for this Symposium Proceedings. An emphasis has been placed on the description of bioinorganic aspects of vanadium chemistry including speciation in aqueous solutions, hydrolytic and redox reactions with small biogenic molecules, and interactions with amino acids, peptides and proteins. In addition, compounds are described of particular interest for modeling various aspects of enzyme activities exhibited by haloperoxidases, nitrogenases, and phosphatases. Finally, compounds exhibiting insulin-mimetic properties are described and some of their chemistry is summarized. Given the recent increased interest in vanadium chemistry, it is impossible to describe all aspects of current and exciting areas that are under exploration. Thus for some areas of vanadium chemistry, referral to the appropriate literature is made. Furthermore, references also will be made to the biochemical, and pharmacological aspects of vanadium science described elsewhere in these Symposium Proceedings.
Tin Halide Perovskite Polycrystalline Films Formed with Nonhazardous 2-Propanol Solvent (2021)

The use of safe and environmentally friendly materials is an important issue for industrial mass production processes. In this study, we demonstrate the deposition of tin halide perovskite films using environmentally benign 2-propanol as a solvent. Sequential deposition of 2-propanol solutions containing SnBr2 and CH3NH3I led to the formation of CH3NH3SnBr3−xIx, which exhibited good crystallinity and visible-light absorption. The use of safe and environmentally friendly materials is an important issue for industrial mass production processes. In this study, we demonstrate the deposition of tin halide perovskite films using environmentally benign 2-propanol as a solvent. Sequential deposition of 2-propanol solutions containing SnBr2 and CH3NH3I led to the formation of CH3NH3SnBr3−xIx, which exhibited good crystallinity and visible-light absorption.
Protective efficacy and safety of per anum vaccination with inactivated E.coli preparations in one-day-old chicks. (1990)

鶏の敗血症大腸菌症より分離した大腸菌(O2型)を用いて4種類の不活化抗原液(BF:約109CFU/ml含む培養菌液,BFS:BF液を超音波処理した菌液,CF:BF液を遠心によって,約1010CFU/mlに濃縮した菌液,CFS:CF液を超音波処理した菌液)を調整した。これら抗原液を1日齢ヒナにクロアカ接種法(pa法)で免疫,その後20日目にホモ株の致死量を静脈内攻撃し,攻撃後7日後の生存率で評価した。抗原液の内,超音波処理を施したBFSとCFS液で攻撃による生存率が統計的に有意であったが,含有菌量が約10倍量多いCFS液の方が強かった(P<0.01)。一方,超音波処理を施していないBF液とCF液では,生存率の改善傾向は見られたが,その効果は有意ではなかった。超音波処理は,15分間(5分間を3回)で最も強い免疫効果が得られた。その効果はKetodeox-yoctonate (KDO)値や抗体結合性などに相関性が認められ,in vitroでの重要な指標となった。CFS液をpa,筋肉内あるいは皮下接種法で接種した時の免疫性と安全性を調査したところ,免疫効果はpa法(P<0.01)と筋肉内接種法(P<0.05)で認められた。安全性は筋肉内や皮下接種法では接種後の体重増加が有意(P<0.01)に低下したが,pa法ではこのような現象は観察されなかった。CFS液のpa法による免疫効果は接種7日目以降27日間にわたると推察されたが,O抗原型が異なるO78型の攻撃に対して,効果を認めなかった。
Modular field robot deployment for inspection of dilapidated buildings (2019)

Abstract Robotic inspection often relies on building custom platforms for each new deployment; this is a luxury that urban search and rescue (USAR) robots do not have when time is of critical importance. A significant factor for robots deployed in disaster areas is the varying size of voids and access ways in their path. These situations require platforms that can quickly reconfigure on location. With these challenges in mind, we present the NeWheel system: An in‐field reconfigurable robotic platform that allows mobility changes before, and during, deployment. The NeWheel platform also has the advantage of being small enough to be person‐deployable and to travel as checked luggage on a commercial flight. This field report presents the results and learnings from three field trips on Peel Island located off the coast of Brisbane, Australia. These field trips featured the deployment of the NeWheel system in multiple configurations to inspect and map inside historic dilapidated buildings. It demonstrates the potential of the NeWheel in buildings cluttered with debris and with unstable flooring whether they are historically important or in USAR contexts.
A photochemical study of s-triazolo[4,3-b] pyridazine and 3-diazo-4-oxo-3,4-dihydroquinoline (1977)

When subjected to ultraviolet radiation in the presence of an alkene, s-triazolo[4,3-b]pyridazine (STP) undergoes an unusual 3 + 2 photocycloaddition wherein the alkene adds to the 1 and 8 positions of STP with concommitant N4-N5 bond cleavage yielding 5,6-disubstituted-6,7-dihydro-7-methylene (and 7-cyanomethyl)-5H-pyrrolo[1,2-b]-s-triazoles. Amides and esters of indole-3-carboxylic acid have been synthesized by a novel reaction employing the ultraviolet irradiation of 3-diazo-4-oxo-3,4-dihydroquinoline (QDA) in the presence of amines or alcohols respectively. QDA, when irradiated, is postulated to undergo an internal Wolff Rearrangement to Indole-3-ketene which can add any amine or alcohol to form the corresponding amide or ester in modest to good yield.
Mechanisms of Tubulointerstitial Injury in the Kidney: Final Common Pathways to End-stage Renal Failure (2004)

There are many different glomerular disorders, including glomerulonephritis, diabetic nephropathy, and hypertensive nephrosclerosis. However, once glomerular damage reaches a certain threshold, the progression of renal disease is consistent and irreversible. Recent studies emphasized the crucial role of tubulointerstitial injury as a mediator of progression of kidney disease. One common mechanism that leads to renal failure via tubulointerstitial injury is massive proteinuria. Accumulating evidence suggests critical effects of filtered macromolecules on tubular cells, including lysosomal rupture, energy depletion, and tubular injury directly induced by specific components such as complement components. Another common mechanism is chronic hypoxia in the tubulointerstitium. Tubulointerstitial damage results in the loss of peritubular capillaries, impairing blood flow delivery. Interstitial fibrosis also impairs oxygen diffusion and supply to tubular cells. This induces chronic hypoxia in this compartment, rendering a vicious cycle. Development of novel therapeutic approaches against these final common pathways will enable us to target any types of renal disease.
4,4′,5,5′-Tetraamino-3,3′-azo-bis-1,2,4-triazole and the electrosynthesis of high-performing insensitive energetic materials (2020)

Electrochemical azo coupling of guanazine yields novel thermally insensitive high-explosive. DFT and EXPLO6.05 calculations reveal energetic properties that rival RDX making this a potentially cheap, and green alternative to traditional energetics.
A prioritized potential framework for combined computing technologies: IoT, Machine Learning, and blockchain (2022)

In today&apos;s scenario, every organization is dependent on the use of computers for automating business and work. The data generated by the organization is huge and has great significance in analyzing the processes. It can be rightfully called as the lifeblood of any organization. The world of computing requires three technologies: Internet of Things (IoT), machine learning (ML), and blockchain. The confluence of these technologies is inevitable in the coming future due to the benefits which are involved in future applications. There is barely any activity today which is cannot apply the use of these three technologies e.g., healthcare, automation, education, etc. IoT can be defined as interconnection of various autonomous devices which are capable of communicating with each other. IoT requires an intermittent Internet connection and address for every device. The user of these devices can remotely monitor and manage by retrieving the information on a handheld device similar to the cellphone. This way, the devices are connected 24/7 and continuously generating data. Challenges of IoT involve the following: security, connectivity problems, and huge data. The devices can be made capable of taking intelligent decisions by incorporating Artificial Intelligence (AI) and ML technology. ML is a sub-branch of AI. It has got huge potential to detect the patterns and anomalies in the data which is generated by the wireless sensor nodes in IoT. The advanced decision-making process of ML has already influenced our daily routines, for example: banking, healthcare, gaming, transportation, and space exploration. Challenges faced by ML are the following: security, centralized architecture, and resource limitations. To cover the security aspect of these two technologies, blockchain technology is the perfect answer. It is a decentralized peer-to-peer network which stores the records and transactions in blocks which cannot be altered. This technology secures the communication by eliminating the need for any trusted third party. The blocks are stored in such a manner which makes it impossible to hack or tamper the data by taking control of device or capturing the records. This chapter will present a comprehensive and quantitative analysis of the existing research and how these technologies can be a transformative impact for access to information by the users. The convergence of blockchain, ML, and IoT will provide scalable, secure high-level intellectual functioning that will be the new paradigm of digital information. This book chapter presents futuristic potential of convergence of three technologies and elaborate discussion of the past researches.
Ion energy distributions in a pulsed plasma doping system (2005)

Discharge parameters in a pulsed dc plasma doping system have been studied using measurements of time-resolved ion energy distributions, relative ion density, plasma potential, and electron temperature in BF3 and Ar plasmas during active discharge and afterglow periods. Negative plasma potentials are observed when using a hollow cathode to create a plasma while implanting at ultralow energies (&amp;lt;500eV). The kinetics of ion generation and decay in BF3 during the pulse on and off periods have been discussed.
Refinement Types for Secure Implementations (2008)

We present the design and implementation of a typechecker for verifying security properties of the source code of cryptographic protocols and access control mechanisms. The underlying type theory is a λ-calculus equipped with refinement types for expressing pre- and post-conditions within first-order logic. We derive formal cryptographic primitives and represent active adversaries within the type theory. Well-typed programs enjoy assertion-based security properties, with respect to a realistic threat model including key compromise. The implementation amounts to an enhanced typechecker for the general purpose functional language F#; typechecking generates verification conditions that are passed to an SMT solver. We describe a series of checked examples. This is the first tool to verify authentication properties of cryptographic protocols by typechecking their source code.
Permanent Magnet Synchronous Machine Sizing: Effect on the Energy Efficiency of an Electro-Hydraulic Forklift (2011)

The energy efficiency of an electro-hydraulic forklift is significantly improved by using a permanent-magnet-synchronous-motor-servo-drive-based direct pump control to control the position of the fork without control valves. This paper provides a short evaluation of the hydraulic system and a more detailed analysis of the losses of the electric machine drive system. A theoretical approach is taken and the results are verified by practical measurements. Finally, possible improvements of the energy efficiency in the suggested system are discussed.
Lysine 63 Polyubiquitination in Immunotherapy and in Cancer-promoting Inflammation (2009)

Covalent and reversible post-translational modifications of proteins are a common theme in signaling. Ubiquitin conjugation was originally described to target proteins to proteasomal degradation by ubiquitin polymerization involving lysine (K) 48 residues. Differently linked polymers of polyubiquitin have been found that modify proteins without targeting to proteasomal degradation. Instead this pathway creates docking sites for signaling scaffolds that are key to control the nuclear factor-kappaB (NF-kappaB) pathway. Indeed TRAF-2, TRAF-6, and TRAF-3 are E3 ubiquitin ligases that form K63-linked ubiquitin polymers. Therefore signaling via TNF family receptors, IL1R, IL-18R, T-cell receptor (TCR), and Toll-like receptors (TLR) use this type of post-translational modification. Specific enzymes exist (DUBs) that deactivate this system, degrading K63 polyubiquitin chains. Interestingly, mice deficient in these deubiquitinases develop autoimmunity and inflammation. In carcinogenesis, the K63 polyubiquitin pathway is possibly critical for inflammation-driven tumor promotion. The pathway is also critically involved in costimulation of tumor immunity/immunotherapy as well as in the biology of malignant cells themselves. The elements of this new signaling paradigm offer the opportunity for therapeutic exploitation and drug discovery.
Novel antibacterial proteins from entomocidal crystals of Bacillus thuringiensis ssp. israelensis (2005)

Proteins with molecular masses of 36 and 34 kDa (Bti36 and Bti34) were isolated from entomocidal crystals formed by Bacillus thuringiensis ssp. israelensis cells. The samples of Bti36 contained the admixture of a protein with a molecular mass of 33 kDa (Bti33), apparently a product of proteolysis of Bti36. These 3 proteins are significantly different in N-terminal sequences from known delta-endotoxins of B. thuringiensis and show antibacterial activity toward Micrococcus luteus. The combination of Bti36 and Bti33 also suppresses the growth of some other microorganisms including Streptomyces chrysomallus. The effects of the mixture of Bti36 and Bti33 on the M. luteus cell surface and on the surface of S. chrysomallus cells and exospores are similar, but they are different from the effect of endotoxin Cry11A on micrococcal cells.
Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old man with antiphospholipid syndrome (2015)

Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old man with antiphospholipid syndrome -
Surface, bulk, and interface electronic properties of nonpolar InN (2010)

The electronic properties of a-plane and m-plane InN have been investigated by x-ray photoemission spectroscopy, infrared reflectivity, and surface space-charge calculations. Electron accumulation has been observed at the surface of nonpolar InN and the surface Fermi level has been found to be lower than previously observed on InN samples. A high electron density in the InN close to the interface with GaN was found in each nonpolar InN sample.
Beam intensity profile modulation for even surface treatment: Finite element modelling and optical design (2008)

Common laser surface treatment problems arise when using a Gaussian or Top-Hat beam intensity profile to attempt to create an even surface temperature distribution profile (or heat affected zone) in a given material. Annular ring shaped beams have gone some way to achieving a more even temperature distribution and have improved process design in fields such as laser surface hardening and laser welding. The temperature distribution profiles created using various annular ring beam profiles are examined. The effect of varying the Péclet number on the resultant temperature distribution profile is modeled using a finite element modeling package. An investigation of the relationship between process tolerance levels and the optimum Péclet number for even treatment of surfaces is included for a number of different annular beam intensity profiles. Modulation of an annular beam intensity profile is examined in an attempt to achieve an even temperature distribution profile with well defined edges even at high Péclet numbers. Modulation of intensity profile is achieved through an optical design which includes only conventional compound optics.