gebhart/patrepeval huggingface dataset:
The upstream stimulatory factor binds to and activates the promoter of the rat class I alcohol dehydrogenase gene (1991)

The gene encoding rat class I alcohol dehydrogenase (ADH) is expressed primarily in the liver. Recent studies in our laboratories indicate that multiple cellular factors present in the rat liver interact with various regions of the promoter of this gene. One of the regions contains the sequence 5'-CACATG-3' that has an "E box" homology to which a number of transcription factors containing the basic helix-loop-helix motif bind. We now demonstrate that the human transcription factor, upstream stimulatory factor (USF), a basic helix-loop-helix-containing protein, binds to and activates the promoter of the rat class I ADH gene. Electrophoretic mobility shift assays of labeled oligonucleotide containing the 5'-CACATG-3' sequence within the ADH promoter revealed the formation of multiple DNA-protein complexes when nuclear extracts obtained from adult rat liver were used. The binding of proteins to the DNA could be competed away with an oligonucleotide specifying a sequence within the adenovirus major late promoter (MLP) that had previously been shown to bind USF. Similar complexes were observed when electrophoretic mobility shift assays of labeled MLP oligonucleotide were performed with rat liver nuclear extracts. Conversely, nuclear extracts isolated from HeLa cells, cells known to have abundant USF, contain factors that interact with the sequence present in the ADH promoter. This interaction could be competed efficiently by the MLP oligonucleotide. USF synthesized in an in vitro transcription and translation system also binds to the ADH promoter as well as to the MLP. In addition, antiserum directed against USF recognizes factors present in the rat liver nuclear extracts that interact with the ADH promoter. Furthermore, transcription directed from both the ADH and the adenovirus major late promoters was inhibited by an oligonucleotide representing the USF-binding site within the ADH promoter in a cell-free in vitro transcription system. Lastly, an ADH promoter-reporter gene construct was transactivated by an eukaryotic expression vector containing USF in HepG2 cells co-transfected with the two constructs. These experiments demonstrate that USF is present in the rat liver and that it binds to and activates the promoter of the rat class I ADH gene in a sequence-specific manner.
A Role for CD4 in Peripheral T Cell Differentiation (1997)

Naive CD4+ T helper cells (Th) differentiate into one of two well-defined cell types during immune responses. Mature Th1 and Th2 cells regulate the type of response as a consequence of the unique cytokines that they secrete. CD4 serves a prominent role in potentiating antigen recognition by helper T cells. We have examined the role of CD4 in peripheral T cell differentiation by studying helper T cells from mice with a congenital defect in CD4 expression. After protein immunization or infection with Leishmania major, CD4-deficient mice were incapable of mounting antigen-specific Th2 responses, but retained their Th1 potency. CD4-deficient, T cell receptor transgenic T cells were also incapable of Th2 differentiation after in vitro activation. Expression of a wild-type CD4 transgene corrected the Th2 defect of CD4-deficient mice in all immune responses tested. To investigate the role of the cytoplasmic domain, mice reconstituted with a truncated CD4 molecule were also studied. Expression of the tailless CD4 transgene could not rescue the Th2 defect of CD4-deficient mice immunized with protein or CD4-deficient transgenic T cells activated in vitro, raising the possibility that the cytoplasmic domain of CD4 may influence Th2 generation. Expression of the tailless transgene was, however, capable of restoring Th2 development in CD4-deficient mice infected with L. major or CD4-deficient transgenic T cells activated in the presence of recombinant IL-4, demonstrating that the cytoplasmic domain is not absolutely required for Th2 development. Together, these results demonstrate a previously undescribed role of the CD4 molecule. The requirement for CD4 in Th2 maturation reflects the importance of molecules other than cytokines in the control of helper T cell differentiation.
Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection (2009)

The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inflammatory response to infection is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with influenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inflammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease.
Roll Stability Regimes at Low Reynolds Numbers (2015)

A model is developed to predict roll stall in which the wing is represented by a single horseshoe vortex; the pressure distribution on the surface of the wing is calculated and is shown to be responsible for the generation of roll moment during sideslip perturbations. An expression for the roll stability derivative is derived analytically and is found to be Cl,β = − ( α ) / (2AR sinα) for an equilibrium sideslip angle of β = 0◦. Results are favorably compared with previously published experimental data for rectangular flat plate wings at a Reynolds number of 7.5×10. A nondimensional parameter referred to as the damp time is derived to identify aspect ratios for which the damping derivative, Cl,p, is relevant. A simplified 3×3 linear system for the lateral dynamics of LAR wings is presented which only requires the Cl,β and Cl,p derivatives, and is evaluated for a range of aspect ratios. Fundamentally different stability regimes are discussed. For aspect ratios below 3.3, roll damping is not significant and an unstable Dutch roll-type mode is dominant. As the aspect ratio is increased above 4.6, the roll subsidence mode remains dominant and the Dutch roll mode becomes stable as the wing behaves in a more conventional manner. The disparity in lateral stability regimes between high and low aspect ratios suggests a potential cause for Micro Aerial Vehicle instabilities.
Frequency Reconfigurable Implant Antenna for MICS and ISM Band Applications (2018)

Frequency reconfigurable compact antenna is presented in this paper for biomedical implant applications. Switching between two frequency bands of Medical Implant Communications Services (402-405 MHz) and Industrial Scientific and Medical (902-928 MHz) bands are realized by using PIN diodes. The overall size of the antenna element is compact with dimensions of 15 × 12 × 0.635 mm. Two radiating element configuration of spiral and monopole are embedded in the top layer of substrate Rogers RT6010 for the radiations in the MICS and ISM frequency bands. The proposed antenna is analyzed and optimized in CST for various dimensions of spiral segments, monopole and coplanar waveguide ground plane. The frequency response for the two states of the proposed antenna along with radiation plots are presented for verification of the concept.
Anisotropy of magnetoelastic properties in epitaxial Co2FexMn1−xSi Heusler alloy thin films (2022)

A strain modulated ferromagnetic resonance technique was applied to determine two cubic magnetoelastic constants of the epitaxially grown 30-nm-thick ${\mathrm{Co}}_{2}{\mathrm{Fe}}_{x}{\mathrm{Mn}}_{1\ensuremath{-}x}\mathrm{Si}$ magnetic layers with different Fe and Mn contents, which were deposited on a MgO substrate with a 20-nm-thick Cr buffer layer---MgO (001) $\ensuremath{\parallel}$ Cr(001) $\ensuremath{\parallel} {\mathrm{Co}}_{2}{\mathrm{Fe}}_{x}{\mathrm{Mn}}_{1\ensuremath{-}x}\mathrm{Si}$ (001). It was found that, for the samples with the Fe content $x=0.4$ or higher, the magnitudes of the two cubic magnetoelastic constants are clearly different, showing that the magnetoelastic properties of these samples are different than in the case of isotropic samples for which these two constants are expected to be equal. The magnitude of the cubic magnetocrystalline anisotropy constant reveals an evident maximum at the composition of $x=0.4$, which corresponds to the minimum of the minor spin density of states, and thus the correlation between the cubic magnetocrystalline anisotropy and the electronic band structure. For all the investigated samples, a large perpendicular component of the magnetocrystalline anisotropy was observed as well as inhomogeneous broadening of the ferromagnetic resonance linewidth.
Flavor Descriptive Terms for Sesame Seed Oil and Principal Components Analysis of Sensory Data. (1997)

市販品,及び試作品の中からフレーバー特性の異なる29種類のごま油の官能評価を行い,得られた結果を主成分分析により解析し,各々のごま油のフレーバーを客観的に特徴付けた.(1) ごま油のフレーバーを特徴付ける用語として抽象的用語37語,具体的用語26語,計63語が挙げられた.(2) ごま油フレーバーの評価用語として適正であるかどうかみる為にアンケート調査を行い,さらには専門パネルによる実試料の評価に基づいた評価用語のスクリーニングと新たな評価用語の追加を行った結果,香ばしい,劣化した,強い,苦い,軽い,複雑な,後に残る,まろやかな,渋い,ナッツ様の10語をごま油フレーバーの評価用語として選択した.(3) 29種類のサンプルについて,専門パネルにて評価用語10語について6段階で官能評価を行った.得られた評価データを主成分分析で解析したところ,29種類のごま油はそのフレーバー特性に基づいて9つのグループに分けることができた.(4) 熱風焙煎試作品は苦い,渋い,後に残るという共通の特徴を有しており,焙煎強度が高いほど,その傾向が強かった.遠赤外線焙煎試作品は,軽い,まろやかな,ナッツ様,複雑な,香ばしい特徴を有しており,焙煎強度が高いほど,複雑な,香ばしい風味が増し,低いほど軽い,まろやかな風味が増した.
C1q induces chemotaxis and K+ conductance activation coupled to increased cytosolic Ca2+ in mouse fibroblasts. (1988)

Cultured mouse fibroblasts (L cells) respond to whole C with a slow hyperpolarization. Among the C components tested, C1q was found to be most effective. In contrast, the cell did not respond to C1, in which the collagen-like region of the C1q molecule is masked. The C1q-induced hyperpolarizing response was inhibited by collagen or C1q-specific antisera. Human diploid skin fibroblasts (Flow 1,000 cells) also exhibited similar membrane potential changes in response to whole C or C1q. After repeated applications of C1q, the cell membrane became unresponsive (desensitized). The treatment of L cells with pronase E inhibited the C1q-induced response, whereas the response to ATP, which is known to interact to its own receptor, was still preserved. The reversal potential of C responses was close to the K+ equilibrium potential. The hyperpolarizing response was inhibited by a blocker of Ca2+-activated K+ channels in fibroblasts (quinine), by deprivation of extracellular Ca2+ or by a Ca2+ channel blocker (nifedipine). By means of Ca2+-selective microelectrodes, the cytosolic free Ca2+ concentration was found to increase from 126 to 206 nM upon stimulation of L cells with C1q. Using an agarose-well method, L cells were observed to migrate predominantly toward C1q or whole C. It is concluded that the fibroblasts have the C1q receptor sensitive to pronase E and that activation of C1q receptors gives rise to Ca2+ influx, triggering an increase in the cytosolic free Ca2+ ions, which in turn induces a hyperpolarizing response as a result of the stimulation of Ca2+-activated K+ channels and initiates chemotaxis to C1q.
Measurement Based Investigation of Cooperative Relaying (2006)

In this paper we present measurements that involve two access points (APs) and two user terminals, each of which is equipped with 4 antennas, in an indoor office environment. The data allow for the simultaneous characterization of the multiple input-multiple output (MIMO) links from the APs to the user terminals and between the user terminals, and are, to the best of our knowledge, the first of their kind. We show that the links between user terminals are impaired by body shadowing, and have therefore much lower gains than the direct links to the APs. Moreover we investigate the statistics of the links, and their correlation. Based on these measurements, we investigate the performance of cooperative relaying in terms of rate improvement (for this analysis the data from only one AP are used). We show that a significant rate improvement can be achieved if the relaying node is free to set the power level at which it transmits, and if it is free to select which of its antennas is used to perform the relaying.
Simple, Efficient Chemoenzymatic Synthesis of (S)-5-(tert-Butyldimethylsilyloxy)-2-cyclohexenone and Enantiomeric Ketone Intermediates of 19-Nor-1α,25-dihydroxyvitamin D3 (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSimple, Efficient Chemoenzymatic Synthesis of (S)-5-(tert-Butyldimethylsilyloxy)-2-cyclohexenone and Enantiomeric Ketone Intermediates of 19-Nor-1α,25-dihydroxyvitamin D3Uttam R. Kalkote, Sandeep R. Ghorpade, Subhash P. Chavan, and T. RavindranathanView Author Information Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India − 411 008 [email protected]Cite this: J. Org. Chem. 2001, 66, 24, 8277–8281Publication Date (Web):November 6, 2001Publication History Received24 September 2001Published online6 November 2001Published inissue 1 November 2001https://pubs.acs.org/doi/10.1021/jo016141ghttps://doi.org/10.1021/jo016141gbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views910Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Ethers,Hydrolysis,Ketones,Optimization,Organic compounds Get e-Alerts
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins (2008)

Multiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited clinical success. As various antiapoptotic mechanisms render GBM cells resistant to chemo- and radiotherapy, we hypothesized that these antiapoptotic mechanisms also confer resistance to RTK inhibition. We found that in vitro inhibition of PDGFR in human GBM cells initiated the intrinsic pathway of apoptosis, as evidenced by mitochondrial outer membrane permeabilization, but downstream caspase activation was blocked by inhibitor of apoptosis proteins (IAPs). Consistent with this, inhibition of PDGFR combined with small molecule inactivation of IAPs induced apoptosis in human GBM cells in vitro and had synergistic antitumor effects in orthotopic mouse models of GBM and in primary human GBM neurospheres. These results demonstrate that concomitant inhibition of IAPs can overcome resistance to RTK inhibitors in human malignant GBM cells, and suggest that blockade of IAPs has the potential to improve treatment outcomes in patients with GBM.
Real time harmonic elimination using a modified carrier (2012)

The paper proposes a harmonic elimination technique that is based on comparison modulation with a modified carrier. Typically, selective harmonic elimination method calculates the switching angles offline using iterative computations and programmed into a digital processor. Here we are advancing a modulation-based harmonic elimination technique to remove the unwanted harmonics. It is a novel PWM method where a reference sinusoid with the desired signal frequency is compared against a modified carrier signal with the same time period as the reference. Simulation and laboratory studies are included.
Inhibition of CD23‐dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules (2010)

Vaccination with both recombinant Bet v 1 derivatives induces Bet v 1-specific IgG antibodies, which are able to inhibit the co-operative binding of allergen-IgE complexes to CD23, and may thereby reduce allergen-specific T cell responses.
Schlußbetrachtung (1997)

In der vorliegenden Arbeit wird zum ersten Mal eine Modellgruppe für die Bewertung industrieller Forschung und Entwicklung von Kapitalgesellschaften entwickelt, die simultan auf vier wesentliche Problemaspekte eingeht:
Crystallization theory (2010)

A basic understanding of crystallization theory exists through the phase‐diagram description. More detailed theories are available but no one theory can currently predict crystallization behaviour. In this chapter we discuss the basic theory and present a typical phase diagram.
Static Sample Magnetometer: A New Characterization Method for Low Permeability Materials and Ferrofluids (2014)

In this paper, an original magnetometer dedicated to static sample characterization is proposed. It is especially designed for ferrofluids whose behaviors are sensitive to the magnetic field and for which the classic methods using a mobile sample are no more suitable. The magnetometer can also be used to test any feebly permeability material. The paper outlines the characterization device and its use in four sections. The first describes the principle of the measurement and the physical and mathematical approach for the reconstruction of the J(H) curve. The second develops the magnetometer design, practical realization, and calibration. In the third section, a numerical validation of the magnetometer and J(H) construction is performed owing to finite element simulation of the magnetometer. Finally, an experimental validation is investigated on a solid specimen made of a weak permeability iron composite. The results are compared with those achieved with an extraction magnetometer and show a good agreement as the differences observed reach a few percent.
ChemInform Abstract: Enantioselective Syntheses with Titanium‐Carbohydrate Complexes. Part 6. A Facile Synthesis of Optically Pure (‐)‐(S)‐Ipsenol (IV) Using a Chiral Titanium Complex. (1990)

Abstract A stereocontrolled synthetic route to optically pure (‐)‐(S)‐ipsenol (IV), the pheromone of Pityokteines curvidens and other bark‐beetle species is described.
[The prognosis of ovarian cancer depends on the CA125 value at the end of induction therapy]. (1991)

The prognosis of ovarian cancer depends on the CA125 value at the end of induction therapy. The relationship between the prognosis and the CA125 value at the end of induction therapy was analysed in 16 ovarian cancers. In the group with a CA125 value less than 35 units/ml after the induction therapy (initial surgery + 3 courses of chemotherapy) all patients have survived for 18-45 months since the initial treatment to the present, whereas in the group with a CA125 value above 35 units/ml all patients died within 16 months after the initial treatment. Comparison of the survival rates in these two groups showed a significant difference. These results suggest that the most important factor that affects prognosis in patients with ovarian cancer is the normalization of the CA125 value after the induction therapy.
Rapid Auditory Processing in Normal and Disordered Language Development (1976)

Four-and-one-half- to eight-and-one-half-year-old children with normal language development, normal adults, and dysphasic children were tested for their ability to perceive binary sequences of nonverbal auditory stimuli. Performance was studied in relation to the rate of presentation of stimulus sequence, as measured by the time interval between stimulus elements. Of the normal children studied, only the eight-and-one-half-year-old group responded as well as the adult group to auditory patterns composed of complex tones presented in rapid succession (8-305 msec intervals). Normal children six-and-one-half years and older were able to respond to these same auditory patterns when they were presented more slowly (947-4026 msec intervals). The overall pattern of performance of the dysphasic children was not similar to that of any age group of children with normal language development. The dysphasics' performance was significantly poorer than that of even the four-and-one-half-year-old normal group on rapidly presented auditory sequences, but not significantly different from normal children their own age or adults on the same patterns which were presented more slowly. The interrelation of normal development of rapid auditory processing and normal language development is discussed.
Synthetic methods. 19. Lewis acid catalyzed conversion of alkenes and alcohols to azides (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic methods. 19. Lewis acid catalyzed conversion of alkenes and alcohols to azidesAlfred Hassner, Richard Fibiger, and Donald AndisikCite this: J. Org. Chem. 1984, 49, 22, 4237–4244Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://doi.org/10.1021/jo00196a025RIGHTS & PERMISSIONSArticle Views1867Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (889 KB) Get e-Alerts Get e-Alerts