gebhart/patrepeval huggingface dataset:
Zero-Point Vibrational Effects on Proton Shieldings:  Functional-Group Contributions from ab Initio Calculations (2001)

We investigate the effects of zero-point vibrational motion on the nuclear magnetic shielding constants of a large number of organic molecules. The vibrational corrections include anharmonic contributions from the potential energy surface and harmonic contributions from the curvature of the property surface. Particular attention is paid to vibrational corrections to hydrogen shielding constants where we show that vibrational corrections may be substantial, ranging from about +0.50 to -0.70 ppm, and thus demonstrating that ignoring these effects may give errors in the chemical shifts by more than 1 ppm in certain extreme cases. These effects can therefore not be neglected when comparing calculated results with experiment, not even for the chemical shifts. However, we also demonstrate that the vibrational corrections to the hydrogen shieldings are to a large extent transferable from one molecule to another. We have tabulated functional vibrational corrections to the hydrogen shieldings, based on results for more than 35 molecules. Unfortunately, no similar transferability has been observed for the vibrational corrections to shielding constants of other nuclei such as carbon, nitrogen, or oxygen.
Plant cell walls and the control of growth (1997)

Conference Article| February 01 1997 Plant cell walls and the control of growth S. McQueen-Mason S. McQueen-Mason 1The Plant Laboratory, Department of Biology, University of York, York YOI 5DD, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: July 23 1996 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1997 Biochemical Society1997 Biochem Soc Trans (1997) 25 (1): 204–214. https://doi.org/10.1042/bst0250204 Article history Received: July 23 1996 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation S. McQueen-Mason; Plant cell walls and the control of growth. Biochem Soc Trans 1 February 1997; 25 (1): 204–214. doi: https://doi.org/10.1042/bst0250204 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: XET, xyloglucan endotransglycosylase This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Alert Verification Determining the Success of Intrusion Attempts (2004)

Recently, intrusion detection systems (IDSs) have been increasingly brought to task for failing to meet the expectations that researchers and vendors were raising. Promises that IDSs would be capable of reliably identifying malicious activity never turned into reality. While virus scanners and firewalls have visible benefits and remain virtually unnoticed during normal operation, intrusion detection systems are known for producing a large number of alerts that are either not related to malicious activity (false positives) or not representative of a successful attack (non-relevant positives). Although tuning and proper configuration may eliminate the most obvious spurious alerts, the problem of the vast imbalance between actual and false or non-relevant alerts remains.
A stacked SONOS technology, up to 4 levels and 6nm crystalline nanowires, with gate-all-around or independent gates (Φ-Flash), suitable for full 3D integration. (2009)

National audience
ChemInform Abstract: Syntheses and Identification of the Most Abundant Urinary Type VI Isoprostanes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluating phloem sap δ13C as a short-term indicator of drought stress in banana (2023)

ISHS XXXI International Horticultural Congress (IHC2022): XII International Symposium on Banana: Celebrating Banana Organic Production Evaluating phloem sap δ13C as a short-term indicator of drought stress in banana
Validity of the single-particle description and charge noise resilience for multielectron quantum dots (2015)

We construct an optimal set of single-particle states for few-electron quantum dots (QDs) using the method of natural orbitals (NOs). The NOs include also the effects of the Coulomb repulsion between electrons. We find that they agree well with the noniteracting orbitals for GaAs QDs of realistic parameters, while the Coulomb interactions only rescale the radius of the NOs compared to the noninteracting case. We use NOs to show that four-electron QDs are less susceptible to charge noise than their two-electron counterparts.
Thermal Characteristics of Soluble Starch Synthase From Wheat Endosperm (1995)

The aim of the work reported in this paper was to characterise the thermal responses of soluble starch synthase (SSS) extracted from the endosperm of the developing wheat grain. Using partially purified preparations of SSS, the reaction obeyed Michaelis-Menten kinetics with both substrates amylopectin and ADPglucose. Both the Vmax and the Km varied with temperature. Values for Vmax were higher at 45ºC compared with 25ºC. However, the Km values for both substrates were also higher at 45ºC than at 25ºC indicating that the affinity of the enzyme for its substrates was reduced at the higher temperature. Over the temperature range 15-45ºC, the Km for arnylopectin was minimal at 20ºC, and rose exponentially between 25 and 45ºC. Kinetic analyses indicated that the reaction was sequential and that the substrates could bind to the enzyme in either order. At 25ºC the binding of one substrate to the enzyme increased the affinity of the complex for the second substrate but at 45ºC these effects were abolished. These thermal characteristics of SSS could explain certain important features of the temperature responses of starch deposition in the wheat grain in vivo.
Mechanism of Phosphoglycolate Phosphatase (1978)

Enzymatic hydrolysis of phosphoglycolate proceeds through O-P bond cleavage as determined by reaction in H218O and analysis of the trimethylsilyl derivatives of the reaction products by mass spectrometry. No phosphate, hydroxyl, or carboxyl exchange occurred. End product inhibition was consistent with an ordered release of products, first the alcoholic product, glycolate, then phosphate. Analysis of the data indicated that the phosphate.enzyme complex dissociated very rapidly, and this was confirmed by use of alternative phosphomonoester substrates. Maximum velocity with these alternate substrates was found to be proportional to the pKa of of the corresponding alcoholic product, indicating the rate-limiting step in the reaction was protonation of the bridge oxygen. The use of substrate analogs further suggested that enzymatic specificity residues in exacting steric requirements for binding, and that large alkyl groups were excluded on this basis. Phosphoglycolate phosphatase catalyzed transphorylation to a wide range of acceptors and was inhibited at the active site by diisopropyl-fluorophosphate. The data suggest that the reaction sequence proceeds via a phosphoenzyme intermediate. N-Ethylmaleimide slowly inactivated the enzyme, the rate being greatly increased by P-glycolate, but not by magnesium or phosphate ions. The data suggest a conformational change is necessary to induce the transition state complex and phosphoenzyme formation. This may account for the phosphate acceptor specificity and is consistent with the failure to observe an enzyme-mediated H2O-phosphate oxygen exchange.
An end-to-end approach for optimal mode selection in Internet video communication: theory and application (2000)

Rate-distortion (R-D) optimized mode selection is a fundamental problem for video communication over packet-switched networks. The classical R-D optimized mode selection only considers quantization distortion at the source. Such an approach is unable to achieve global optimality under the error-prone environment since it does not consider the packetization behavior at the source, the transport path characteristics, and receiver behavior. This paper presents an end-to-end approach to generalize the classical theory of R-D optimized mode selection for point-to-point video communication. We introduce a notion of global distortion by taking into consideration both the path characteristics (i.e., packet loss) and the receiver behavior (i.e., the error concealment scheme), in addition to the source behavior (i.e., quantization distortion and packetization). We derive, for the first time, a set of accurate global distortion metrics for any packetization scheme. Equipped with the global distortion metrics, we design an R-D optimized mode selection algorithm to provide the best tradeoff between compression efficiency and error resilience. The theory developed in this paper is general and is applicable to many video coding standards, including H.261/263 and MPEG-1/2/4. As an application, we integrate our theory with point-to-point MPEG-4 video conferencing over the Internet, where a feedback mechanism is employed to convey the path characteristics (estimated at the receiver) and receiver behavior (error concealment scheme) to the source. Simulation results are discussed.
Syntheses of Peptides Related to the N-Terminal Structure of Corticotropin. IV. The Synthesis of the Amino Acid Sequences, Lys-Pro-Val-Gly and Lys-Pro-Val-Gly-Lys (1964)

Abstract The amino acid sequence Lys-Pro-Val-Gly-Lys, which corresponds to positions 11 to 15 of the corticotropin molecule, has been synthesized in the form of a crystalline derivative, Nα-carbobenzoxy-Nε-t-butyloxycarbonyl-l- lysyi-l-prolyl-l-valyl-glycyl-Nε-t-butyloxycarbonyl-l-lysine methyl ester, from which the crystalline hydrazide has then been obtained. The syn-thesis of the Lys-Pro-Val-Gly sequence corresponding to positions 11 to 14 of corticotropin has also been described.
Current ratio log amplifier using light emitting diodes (1982)

Abstract Use of a diode or transistor as the log element in log amplifiers is well established. As log amplifiers moat often use a silicon log element, their output can never exceed 0.0 V. Such a low output necessitates fine adjustment of the offset voltage of the operational amplifiers. Furthermore the lower current limit of logarithmic current-to-voltage converters is governed by the leakage current of the log element which for present day commercial log amplifiers is limited to about 10-9 A. This limit can be reduced to some extent by the use of low leakage diodes or FETs. The low leakage properties of large bond gap diodes particularly GaAaP diodes, commercially available as LEDs has recently been pointed out. The authors present a design of current ratio log amplifier based on these diodes which has a dynamic range at least three orders magnitude better than log amplifiers currently available The design is simple and uses commercially available components.
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases (2012)

Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS). However, the molecular mechanisms underlying the correlation between altered cholesterol metabolism and the neurological deficits are, for the most part, not clear. NPC disease and SLOS are caused by mutations in genes involved in the biosynthesis or intracellular trafficking of cholesterol, respectively. However, the types of neurological impairments, and the areas of the brain that are most affected, differ between these diseases. Some, but not all, studies indicate that high levels of plasma cholesterol correlate with increased risk of developing AD. Moreover, inheritance of the E4 isoform of apolipoprotein E (APOE), a cholesterol-carrying protein, markedly increases the risk of developing AD. Whether or not treatment of AD with statins is beneficial remains controversial, and any benefit of statin treatment might be due to anti-inflammatory properties of the drug. Cholesterol balance is also altered in HD and PD, although no causal link between dysregulated cholesterol homeostasis and neurodegeneration has been established. Some important considerations for treatment of neurodegenerative diseases are the impermeability of the blood-brain barrier to many therapeutic agents and difficulties in reversing brain damage that has already occurred. This article focuses on how cholesterol balance in the brain is altered in several neurodegenerative diseases, and discusses some commonalities and differences among the diseases.
Predictors of Histological Disease Progression in Untreated, Localized Prostate Cancer (2007)

Repeat biopsy should be an integral part of active surveillance for untreated localized prostate cancer. Immediate repeat biopsy should be considered in patients who elect active surveillance but who have prostate specific antigen density greater than 0.2 ng/ml/ml. These findings must be validated in a cohort of patients with extended biopsies at diagnosis and followup.
Microsoft Visual C++ .NET (2002)

Note: Trad. de Microsoft Visual C++.net par Fabrice Lemaique.- Avec index Reference Record created on 2004-09-07, modified on 2016-08-08
Compressive sensing underwater laser serial imaging system (2013)

Compressive sensing (CS) theory has drawn great interest in recent years and has led to new image-acquisition techniques in many different fields. This research investigates a CS-based active underwater laser serial imaging system, which employs a spatial light modulator (SLM) at the source. A multiscale polarity-flipping measurement matrix and a model-assisted image reconstruction concept are proposed to address limitations imposed by a scattering medium. These concepts are also applicable to CS-based imaging in atmospheric environments characterized by fog, rain, or clouds. Simulation results comparing the performance of the proposed technique with that of traditional laser line scan (LLS) sensors and other structured illumination-based imager are analyzed. Experimental results from over-the-air and underwater tests are also presented. The potential for extending the proposed frame-based imaging technique to the traditional line-by-line scanning mode is discussed.
Capacity and Coverage Analysis of a 3GPP-LTE Multihop Deployment Scenario (2008)

Broadband wireless access will be deployed in a cellular way with 3GPP-LTE [1]. For the first rollout the main demand is a huge area coverage. With only few available base station sites that are connected to an access fiber, multihop (relaying) techniques can be used well to fill the coverage gaps. Later with increasing offered traffic, the demand shifts to higher capacity over the area. Even for this purpose relays are beneficial. There is an area around relays where they provide better overall capacity to the user terminal, taking into account all resources used for the first and second hop (the relaying overhead). Relaying or Multihop operation therefore massively improves the coverage as well as the capacity goals at low cost, without the need of a cable or fiber access. This paper analyzes a realistic urban scenario on the island of Jersey. We study the coverage and capacity over the area in three cases. One base station (BS) only, one BS with four relay nodes (RNs), and the latter plus another ring of nine RNs. The BS has fiber access for rates beyond 100 Mbit/s, while the first hop of Relays (HI) is fed over the air from BS using shared resources in the same LTE band. The second hop H2 is fed by the relays of group HI. In this paper we provide the results from numeric analysis based on models we explain here. It is shown that huge gains in coverage and capacity are obtained by relaying.
Nonspectroscopic approach to the determination of the chemical potential and band-gap renormalization in quantum wells (1992)

An experimental approach to the determination of the band-gap renormalization caused by many-body effects in quantum wells (QW's) at room temperature is presented. The chemical potential and the corresponding plasma density are derived from independent measurements of the junction voltage and the differential carrier lifetime in GaAs/${\mathrm{Al}}_{\mathit{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$As single-quantum-well (laser) diodes as a function of the carrier-injection rate. Within a plasma-density range from 3\ifmmode\times\else\texttimes\fi{}${10}^{11}$ to 7\ifmmode\times\else\texttimes\fi{}${10}^{12}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$, the renormalization of the chemical potential is determined from the difference between the measured chemical potential and the calculated noninteracting chemical potential that would be observed in the absence of a band-gap shrinkage. If the occupation of higher subbands is negligible, this difference equals the renormalization of the fundamental band gap. Corresponding requirements to the design of QW structures are discussed. The experimentally determined renormalization of the chemical potential is compared to results of a detailed theoretical calculation of band-gap renormalization, taking into account the self-energy shifts of all subbands of the complex QW device.
Data from IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Although successes in cancer immunotherapy have generated considerable excitement, this form of treatment has been largely ineffective in patients with pancreatic ductal adenocarcinoma (PDA). Mechanisms that contribute to the poor antitumor immune response in PDA are not well understood. Here, we demonstrated that cytokine IL35 is a major immunosuppressive driver in PDA and potentiates tumor growth via the suppression of endogenous antitumor T-cell responses. The growth of pancreatic tumors in mice deficient for IL35 was significantly reduced. An analysis of tumor-infiltrating immune cells revealed a role for IL35 in the expansion of regulatory T cells and the suppression of CD4&lt;sup&gt;+&lt;/sup&gt; effector T cells. We also detected a robust increase in both the infiltration and activation of cytotoxic CD8&lt;sup&gt;+&lt;/sup&gt; T cells, suggesting that targeting IL35 may be an effective strategy to convert PDA from an immunologically “cold” to “hot” tumor. Although PDA is typically resistant to anti–PD-1 immunotherapy, we demonstrated robust synergistic reduction in tumor growth when IL35 deficiency was combined with anti–PD-1 treatment. These findings provide new insight into the function of IL35 in the pathogenesis of pancreatic cancer and underscore the potential significance of IL35 as a therapeutic target for use in combination immunotherapy approaches in this deadly malignancy. &lt;i&gt;Cancer Immunol Res; 6(9); 1014–24. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Predicting Parkinson disease related genes based on PyFeat and gradient boosted decision tree (2022)

Identifying genes related to Parkinson's disease (PD) is an active research topic in biomedical analysis, which plays a critical role in diagnosis and treatment. Recently, many studies have proposed different techniques for predicting disease-related genes. However, a few of these techniques are designed or developed for PD gene prediction. Most of these PD techniques are developed to identify only protein genes and discard long noncoding (lncRNA) genes, which play an essential role in biological processes and the transformation and development of diseases. This paper proposes a novel prediction system to identify protein and lncRNA genes related to PD that can aid in an early diagnosis. First, we preprocessed the genes into DNA FASTA sequences from the University of California Santa Cruz (UCSC) genome browser and removed the redundancies. Second, we extracted some significant features of DNA FASTA sequences using the PyFeat method with the AdaBoost as feature selection. These selected features achieved promising results compared with extracted features from some state-of-the-art feature extraction techniques. Finally, the features were fed to the gradient-boosted decision tree (GBDT) to diagnose different tested cases. Seven performance metrics were used to evaluate the performance of the proposed system. The proposed system achieved an average accuracy of 78.6%, the area under the curve equals 84.5%, the area under precision-recall (AUPR) equals 85.3%, F1-score equals 78.3%, Matthews correlation coefficient (MCC) equals 0.575, sensitivity (SEN) equals 77.1%, and specificity (SPC) equals 80.2%. The experiments demonstrate promising results compared with other systems. The predicted top-rank protein and lncRNA genes are verified based on a literature review.
Nucleotide sequencing and DNA polymorphism studies of beta-lactoglobulin gene in native Saudi goat breeds in relation to milk yield (2015)

β-Lactoglobulin (β-LG) is the dominant non-casein whey protein found in milk of bovine and of most ruminants. The amino acid sequence of β-LG along with its 3-dimensional structure illustrates linkage with the lipocalin superfamily. Preliminary studies in goats indicated that milk yield can be influenced by polymorphism in genes coding for whey proteins. The aim of this study is to identify and evaluate the incidence of functional polymorphisms in the exonic and intronic portions of β-LG gene in native Saudi goat breeds (Ardi, Habsi and Harri). Blood samples were collected from 300 animals (100 for each breed) and genomic DNA was extracted using QIAamp DNA extraction kit. A fragment of the β-LG gene from exon 7 to 3' flanking region was amplified with pairs of specific primers. Subsequent digestion with Sac II restriction endonuclease revealed two alleles (A and B) and three different banding patterns or genotypes, i.e. AA, AB, and BB. The statistical analysis showed that β-LG AA genotype had higher milk yield than β-LG AB and β-LG BB genotypes. Nucleotide sequencing of the selected β-LG fragments was done and submitted to GenBank NCBI (Accession Nos. KJ544248, KJ588275, KJ588276, KJ783455, KJ783456, KJ874959, and KP269078). Two already established SNPs in exon 7 (+4601 and +4603) and one fresh SNP in the 3' UTR region were detected in the β-LG fragments with designated AA genotype. The exonic SNPs, i.e. +4601 (G/A) and +4603 (G/C), were found within the Sac II restriction site and accountable for generating the AA genotypic patterns. Hence, the allele characterized by the substitution G>A has been sub-designated as AAA, while the one characterized by the substitution G>C as AAC. The polymorphisms in exon 7 did not produce any amino acid substitution.
A Proposal for a Missouri River Corridor Trust (2002)

Encouraging citizen cooperation while minimizing cost and governmental regulation.Resource protection is greatly enhanced when local citizens also share the goals, participate in achieving