gebhart/patrepeval huggingface dataset:
Pharmacological Properties of a New Anti-Inflammatory Compound, α-(3,5-Di-Tert-Butyl-4-Hydroxybenzylidene)-γ-Butyrolactone (KME-4), and Its Inhibitory Effects on Prostaglandin Synthetase and 5-Lipoxygenase (1984)

The pharmacological effects of a new anti-inflammatory compound, alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its inhibitory effects on arachidonate prostaglandin synthetase and 5-lipoxygenase activities were examined. KME-4 showed anti-inflammatory activity. It was less active than indomethacin, but more active than naproxen and ibuprofen in carrageenin-induced paw edema in rats; and it was less active than indomethacin, equipotent as naproxen, but more active than ibuprofen in granuloma formation in rats. The ulcerogenic activity of KME-4 was weaker than indomethacin and naproxen, but stronger than ibuprofen in starved rats. The ratio of UD50 stomach to ED30 carrageenin edema or to ED25 granuloma for KME-4 showed higher values than those of the reference drugs. KME-4 showed antipyretic activity in yeast-induced fever in rats. It also inhibited platelet aggregation induced by arachidonic acid and protected rabbits from arachidonic acid-induced death. Furthermore, KME-4 was found to be equipotent in inhibiting both prostaglandin synthetase and 5-lipoxygenase activities of rat basophilic leukemia cells, unlike indomethacin, naproxen and ibuprofen. It also inhibited the prostaglandin synthetase activity of bovine seminal vesicle. The present findings indicate that KME-4 may be a new type of anti-inflammatory drug with dual prostaglandin synthetase and 5-lipoxygenase inhibition.
A Case Study in Automated Molecular Microscopy (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006
CaTGrasp: Learning Category-Level Task-Relevant Grasping in Clutter from Simulation (2021)

Task-relevant grasping is critical for industrial assembly, where downstream manipulation tasks constrain the set of valid grasps. Learning how to perform this task, however, is challenging, since task-relevant grasp labels are hard to define and annotate. There is also yet no consensus on proper representations for modeling or off-the-shelf tools for performing task-relevant grasps. This work proposes a framework to learn task-relevant grasping for industrial objects without the need of time-consuming real-world data collection or manual annotation. To achieve this, the entire framework is trained solely in simulation, including supervised training with synthetic label generation and self-supervised, hand-object interaction. In the context of this framework, this paper proposes a novel, object-centric canonical representation at the category level, which allows establishing dense correspondence across object instances and transferring task-relevant grasps to novel instances. Extensive experiments on task-relevant grasping of densely-cluttered industrial objects are conducted in both simulation and real-world setups, demonstrating the effectiveness of the proposed framework. Code and data are available at https://sites.google.com/view/catgrasp.
Whole Grain Gluten-free Egg-free Pastas (2013)

The USDA food guidelines recommend that at least half of all grains consumed should be whole grains. The U.S. FDA allows health claim labels for foods containing 51% whole grains by weight when the whole grains contain ≥11% dietary fiber. This article describes the development of innovative gluten-free, egg-free (no chemicals added) whole grain pastas made using a kitchen countertop appliance. Whole grain pastas (fusilli) were prepared using corn, millet, brown rice, and sorghum flours. Dough formulations contained 90% whole grain, 6% black gram flour, and 4% guar gum. Sensory panels of in-house volunteers (N = 123) judged the color/appearance of whole grain corn fusilli pasta as significantly (P ≤ 0.05) better than those of the other whole gain pastas tested (corn > brown rice = sorghum > millet). Acceptance rates for these novel health-promoting whole grain pastas were 83% for corn, 79% for sorghum, 77% for rice, and 50% for millet. Gluten-free, egg-free whole grain pastas could aid in increasing whole ...
Controlling In-Plane Isotropic and Anisotropic Orientation of Organic Semiconductor Molecules on Ionic Fluoride Dielectrics (2017)

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In vitro preliminary study of antiprotozoal effect of four medicinal plants from Benin (2013)

A total of fourteen extracts with different polarity obtained from four species Crataeva religiosa, Baillonella toxisperma, Boswellia dalzielii and Khaya senegalensis, traditionally used in Benin to treat malaria were tested for their in vitro antiprotozoal activity towardsPlasmodium falciparum, Trypanosoma rhodesiense, Trypanosoma cruzi and Leishmania donovani. Selected plants were extracting with cyclohexane, methylene chloride, ethyl acetate, ether diethyl, methanol and ethanol. Tested extracts showed moderate to good antiparasitic effects at two different concentrations (9.6 and 1.6 µg/ml). Many extracts showed appreciable growth inhibition at 9.5 µg/ml. Ethanol extract of B. dalzielii was the most active against T. rhodesiense and L. donovani with growth inhibition percentage of 100 and 95.6%, respectively. Seven out of fourteen extracts also showed interesting growth inhibition percentage from 99 to 87%, on P. falciparum at 9.6 µg/ml. The most interesting activity against L. donovani was observed with the cyclohexane extract of C. religiosa with growth inhibition value of 55% at 1.6 µg/ml.

	 

	Key words: Traditional medicine, antimalarial, leishmanicidal, trypanocidal, Benin.
Challenging the Limitations of Atrial Fibrillation Detection in the Presence of Other Cardiac Arrythmias (2020)

Atrial fibrillation (AF) affects millions of people worldwide and needs to be diagnosed in its early stage to provide proper treatment. However, the numerous wearable devices available today are not yet able to discriminate AF episodes from other cardiac arrhythmias and merely detect normal vs abnormal rhythms.In this study we investigated the performance of a traditional classifier - designed to distinguish AF and sinus rhythm (SR) using inter-beat intervals (IBI) - when confronted with other - non-AF - arrhythmias. This classifier was challenged with data of 37 patients wearing an optical heart rate monitor device during catheter ablation procedures. We first analyzed the classification performance of pure AF vs SR and then gradually introduced non-AF arrhythmias in the time windows used for classification.We obtained a high classification performance (accuracy, sensitivity and specificity of 0.979, 1.000 and 0.966) for purely AF and SR. In contrast, when increasing the maximal possible number of non-AF arrhythmias to 50%, the performance decreased to an accuracy, sensitivity and specificity of 0.886, 0.998 and 0.853. While sinus tachycardia led to false positives the classification was not impaired by the presence of extrasystoles, bigeminy, bradycardia, frequent ectopic beats or atrial flutter.Our study quantifies to what extent a traditional IBI-based classifier is not sufficient to distinguish AF from other arrhythmias. Future work should concentrate on acquiring datasets with a high diversity of arrhythmias and employing new classification features.
Mechanisms of Antibiotic Action and Resistance (2001)

This month’s Trends in Microbiology includes a free poster entitled ‘Mechanisms of Antibiotic Action and Resistance’by Christopher T. Walsh, John W. Trauger, Patrice Courvalin and Julian E. Davies, which outlines the targets of avariety of antibiotics and three basic mechanisms of antibiotic resistance. The following references provide anintroduction to the recent literature on antibiotic resistance:Arthur, M. and Courvalin, P. (1993) Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob.Agents Chemother . 37, 1563–1571Chu, D.T. et al. (1996) New directions in antibacterial research. J. Med. Chem . 39, 3853–3874Davies, J. (1994) Inactivation of antibiotics and the dissemination of resistance genes. Science264, 375–381Gold, H.M. and Moellering, R.C. (1996) Antimicrobial-drug resistance. New Engl. J. Med . 333, 1445–1453Levy, S.B. (1998) The challenge of antibiotic resistance. Sci. Am . 275, 46–53Scholar, E.M. and Pratt, W.B. (2000) The Antimicrobial Drugs (2nd edn), Oxford University PressQuintiliani, R. Jr, et al. (1998) Mechanisms of resistance to antimicrobial agents. In Manual of Clinical Microbiology(7th edn) (Murray, P.R. et al., eds), pp. 1505–1525, ASM PressWalsh, C. (2000) Molecular mechanisms that confer antibacterial drug resistance. Nature406, 775–781Wright, G.E. (1999) Aminoglycoside-modifying enzymes. Curr. Opin. Microbiol . 2, 499–503
Ex vivo generation of umbilical cord blood T regulatory cells expressing the homing markers CD62L and cutaneous lymphocyte antigen (2018)

Regulatory T cells (Tregs) are an important component of the immune system involved in regulation of immune cell proliferation and inflammatory responses and preventing autoimmune diseases. The use of Tregs in cellular therapy has recently been explored in clinical trials specifically evaluating the role of <i>ex vivo</i> expanded Tregs in the prevention of graft-versus-host disease during stem cell transplantation. The possibility of Treg use in the clinic requires clinical grade expansion of Tregs for development of cell therapy protocols and proper homing of Tregs to the intended target. Here we demonstrate a novel medium composition to expand CB Tregs, specifically upregulation the homing and activation markers CD62L and cutaneous lymphocyte antigen (CLA). CLA expression was uniquely acquired during activation of Tregs with subsequent loss or lack of expression with media change. This finding highlights the importance of proper growth conditions unique to Tregs that can alter expression of proteins and establishes a baseline for expanding marker specific Tregs that home and target unique tissues.
Supplementary Figure 3 from Deletion of the Endothelial Bmx Tyrosine Kinase Decreases Tumor Angiogenesis and Growth (2023)

&lt;p&gt;PDF file - 196K, Normal postnatal development of retinal vasculature in Bmx deficient mice&lt;/p&gt;
Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening (2020)

: Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel (PZQ), making the discovery of new compounds extremely urgent. In this work, we integrated QSAR-based virtual screening (VS) of Schistosoma mansoni thioredoxin glutathione reductase (SmTGR) inhibitors and high content screening (HCS) aiming to discover new antischistosomal agents. Initially, binary QSAR models for inhibition of SmTGR were developed and validated using the Organization for Economic Co-operation and Development (OECD) guidance. Using these models, we prioritized 29 compounds for further testing in two HCS platforms based on image analysis of assay plates. Among them, 2-[2-(3-methyl-4-nitro-5-isoxazolyl)vinyl]pyridine and 2-(benzylsulfonyl)-1,3-benzothiazole, two compounds representing new chemical scaffolds have activity against schistosomula and adult worms at low micromolar concentrations and therefore represent promising antischistosomal hits for further hit-to-lead optimization.
Activation of Murine RNase L by Isopolar 2‘-Phosphonate Analogues of 2‘,5‘ Oligoadenylates (2006)

To determine the influence of methylene group insertion in the internucleotide linkage on the binding process of 2',5'-oligoadenylates to RNase L, a series of 2'-phosphonate-modified trimers and tetramers were synthesized from appropriate monomeric units and evaluated for their ability to bind to murine RNase L. Tetramers pAAXA modified by ribo-, arabino-, or xylo-2'-phosphonate unit X in the third position were capable of binding to RNase L in nanomolar concentrations. The replacement of the first residue (pXAAA), or both the first and the third residues (pXAXA), was also tolerated by the enzyme. In contrast, in all cases, the replacement of the second residue (pAXAA) resulted in the significant decrease of binding ability. Additionally, no more than two phosphonate modifications in the tetramer were allowed to retain the binding affinity to the enzyme. Although all three tetramers pAAXA were found to be potent enzyme binders, only tetramers modified by ribo- and xylo-2'-phosphonate unit X activated the RNase L-catalyzed cleavage of the RNA substrate. Surprisingly, tetramer pAAXA, modified by arabino-2'-phosphonate unit X, did not activate the enzyme and can be considered a potent antagonist. In comparison with their natural counterpart, the phosphonate analogues of the pA4 exhibit superior resistance toward nucleases present in the murine spleen homogenate.
Ultrasonic trapping of beads in a straight channel (2009)

The trapping of particles or cells using ultrasonic radiation forces is relevant to a range of biological, chemical and medical analyses, for example, those involving cell washing, cell separation or testing of reagents. This work studies the trapping forces within a flow-through chamber designed to detect counterions based on the aggregation position of ion-exchange resin beads. Certain counterions alter the water content of the beads and therefore their acoustic properties; this alters their response to the acoustic field allowing the counterions to be detected by measuring bead position or trapping force. This paper investigates the acoustic radiation force distribution of the device and shows experimentally and computationally that flow rate and resulting fluid drag opposing the longitudinal acoustic radiation forces influence the location of trapped beads. The relationship between location and force is influenced by the uniformity of the axial field and axial displacement of the bead. It is proposed that by characterizing this relationship, the trap location of a resin bead against a constant flow can be used to measure changes in trapping forces and therefore acoustic contrast factor, and as an indicator of certain counterions.
Fibers for Continuum Generation and Frequency Metrology (2006)

Highly-nonlinear, germano-silicate fibers can be integrated with femtosecond fiber lasers and generate octave-spanning supercontinuum at 1.5 mum. Post-processing the fibers with ultra-violet radiation allows for tailoring of the continuum properties for frequency metrology applications
It takes a community--- (2022)

A discussion with Reynold Xin, Wes McKinney, Alan Gates, and Chris McCubbin.
Development of a short-range 355-nm Rayleigh-Mie lidar using a Michelson interferometer for wind speed measurements (2007)

We report the development of a 355-nm lidar system for short-range wind speed measurements, using a fringe-imaging Michelson interferometer as a spectral analyzer. The instrument principle is to deduce the wind speed from the phase variations of the two-wave interference pattern provided by the interferometer. A laboratory demonstrator has been realized, which was designed in an original way to minimize the sensitivity to phase fluctuations caused by thermo-mechanical disturbances and laser drifts. An accurate signal processing has been developed, providing with estimates of five fringe parameters: intensity, contrast, periodicity, angular orientation, and phase. It is implemented in two steps: the first step uses a Fourier transform analysis and the second step a maximum-likelihood estimator. To validate the instrument principle, measurement method and signal processing alltogether, a calibrated speed measurement experiment has been performed on hard target, for which the results are shown.
Additional file 4: of Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition (2016)

is a figure showing that a combination of BYL719/AEW541 triggers apoptosis in BYL719-resistant cell lines. A Anti-cleaved PARP (T47D) or anti-PARP (MCF7) immunoblots of lysates from parental and resistant cells treated for 24 hours as indicated. BYL719 (IC90), AEW541 (1 μM). B Parental and resistant cells were treated with BYL719 (2 μM for T47D and 5 μM for MCF7), AEW541 (1 μM), or the combination BYL719/AEW541 for 72 hours. Percentage of apoptotic (Annexin V-positive and PI-negative) and necrotic cells (Annexin V and PI-positive) are indicated. (PDF 158 kb)
233 COMPARISON OF CLINICAL CHEMISTRY VALUES OF BLOOD SAMPLES OBTAINED FROM RETROBULBAR PLEXUS AND TONGUE VEIN IN RATS (1997)

Jakubowski, J.; Mahl, A.; Lützelschwab, J.; Aebischer, V.; Singer, T.; Cordier, A. Author Information
MultiMATLAB: MATLAB on Multiple Processors (1996)

: MATLAB ® , a commercial product of The MathWorks, Inc., has become one of the principal languages of desktop scientific computing. A system is described that enables one to run MATLAB conveniently on multiple processors. Using short, MATLAB-style commands like Eval, Send, Recv, Bcast, Min, and Sum, the user operating within one MATLAB session can start MATLAB processes on other machines and then pass commands and data between between these various processes in a fashion that maintains MATLAB&amp;apos;s traditional user-friendliness. Multi-processor graphics is also supported. The system currently runs under MPICH on an IBM SP2 or a network of Unix workstations, and extensions are planned to networks of PCs. MultiMATLAB is potentially useful for education in parallel programming, for prototyping parallel algorithms, and for fast and convenient execution of easily parallelizable numerical computations on multiple processors. Keywords: MATLAB, MultiMATLAB, SP2, message passing, MPI, MPICH ...
Dynamic structure in software architectures (1996)

Much of the recent work on Architecture Description Languages (ADL) has concentrated on specifying organisations of components and connectors which are static. When the ADL specification is used to drive system construction, then the structure of the resulting system in terms of its component instances and their interconnection is fixed. This paper examines ADL features which permit the description of dynamic software architectures in which the organisation of components and connectors may change during system execution.The paper outlines examples of language features which support dynamic structure. These examples are taken from Darwin, a language used to describe distributed system structure. An operational semantics for these features is presented in the &pi;-calculus, together with a discussion of their advantages and limitations. The paper discusses some general approaches to dynamic architecture description suggested by these examples.
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases (2009)

Proteins associated with various human diseases are enriched in intrinsic disorder. These disease-associated IDPs and IDRs are real, abundant, diversified, vital, and dynamic. These proteins and regions comprise the disease-related unfoldome, which covers a significant part of the human proteome. Profound association between intrinsic disorder and various human diseases is determined by a set of unique structural and functional characteristics of IDPs and IDRs. Unfoldomics of human diseases utilizes unrivaled bioinformatics and experimental techniques, paves the road for better understanding of human diseases, their pathogenesis and molecular mechanisms, and helps develop new strategies for the analysis of disease-related proteins.
Use of immune modulation by human adipose-derived mesenchymal stem cells to treat experimental arthritis in mice. (2017)

Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammatory cell infiltration and joint erosion. Human adipose-derived mesenchymal stem cells (hASCs) have shown the capacity of suppressing effector T cell activation and inflammatory cytokine expression. We investigated whether hASCs play a therapeutic role in collagen-induced arthritis (CIA) by administering a single dose of hASCs in mice with established CIA. <i>In vivo</i>, a beneficial effect was observed following hASC infusion as shown by a marked decrease in the severity of arthritis. Human ASCs were detectable in the joints, and reduced levels of pro-inflammatory cytokines and increased levels of anti-inflammatory cytokines were observed in the sera of the hASC-treated mice. Furthermore, hASC treatment induced the expansion of regulatory T cells (Tregs) both in the peripheral blood and in the spleen tissues. <i>In vitro</i>, hASCs downregulated the production of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in mouse macrophages stimulated with lipopolysaccharide and inhibited the proliferation of human primary T cells in response to mitogens. Thus hASCs represent a novel and effective therapeutic strategy for RA.
Hypervalent Iodine-Induced Multi-Component Reactions: Novel Thiocyano- and Isothiocyano-phenylselenenylating Reaction of Alkenes (2000)

A simple and efficient thiocyano- or isothiocyano-phenylselenenylation of alkenes has been developed. The reactions occur when alkenes are treated with [bis(acetoxy)iodo]benzene, trimethylsilyl isothiocyanate or potassium thiocyanate and diphenyl diselenide. Mono- and disubstituted alkenes led to the formation of 1,2-phenylseleno-thiocyanates, whereas both more-substituted alkenes and styrenes gave exclusively 1,2-phenylseleno-isothiocyanates. The overall transformation represents the addition of PhSeSCN to the olefinic double bonds, in situ generated by the above reagents combination.
Corrosion of laser joined silicon carbide in gasification environment (2015)

The production of synthesis gas from renewable fuels is an emerging technology. The aggressive process environment in fuel production systems poses a major challenge, potentially causing corrosion within currently used metallic heat exchangers. To improve the reliability and stability of silicon carbide heat pipes, which belong to an innovative heat exchanger design, the corrosion of involved materials due to contact with steam, ash and alkaline (earth) metals needs to be investigated. Exposures of laser joined SSiC connections with wood ash caused the formation of gas inclusions and an infiltration of the joint with alkaline (earth) metals that lead to crack formations, as revealed by energy dispersive X-ray spectroscopy analysis. It was shown that the use of silicon carbide heat pipes joined with solder materials of both the Mg–Al–Si and the Y–Al–Si systems is possible. A further result was that the gasification temperature has to be limited to < 850°C.
Modifizierung von polymeroberflächen zur erhöhung der zelladhäusion (1989)

Abstract After implantation a stable bond between the implant and the surrounding tissue is required. Therefore a high cell adhesion of the polymer surface of the implant must be achieved. Depending on the treatment time of a polydimethylsiloxane foil with oxygen plasma, the cell adhesion can be improved. FT‐IR spectroscopy and ESCA analysis were used to characterize the surface modification. The cell spreading and cell adhesion increase with increasing hydrophilic character of the polymer surface after plasma treatment. A pronounced correlation was found between the efficiency of DNA and protein content, characterizing cell growth, and the spreading of the cells. Polydimethylsiloxane, Glow‐Discharge, Surface Modification, Cell Adhesion, Cell Proliferation.