gebhart/patrepeval huggingface dataset:
Heart rate variability in normal and pathological sleep (2013)

Sleep is a physiological process involving different biological systems, from molecular to organ level; its integrity is essential for maintaining health and homeostasis in human beings. Although in the past sleep has been considered a state of quiet, experimental and clinical evidences suggest a noteworthy activation of different biological systems during sleep. A key role is played by the autonomic nervous system (ANS), whose modulation regulates cardiovascular functions during sleep onset and different sleep stages. Therefore, an interest on the evaluation of autonomic cardiovascular control in health and disease is growing by means of linear and non-linear heart rate variability (HRV) analyses. The application of classical tools for ANS analysis, such as HRV during physiological sleep, showed that the rapid eye movement (REM) stage is characterized by a likely sympathetic predominance associated with a vagal withdrawal, while the opposite trend is observed during non-REM sleep. More recently, the use of non-linear tools, such as entropy-derived indices, have provided new insight on the cardiac autonomic regulation, revealing for instance changes in the cardiovascular complexity during REM sleep, supporting the hypothesis of a reduced capability of the cardiovascular system to deal with stress challenges. Interestingly, different HRV tools have been applied to characterize autonomic cardiac control in different pathological conditions, from neurological sleep disorders to sleep disordered breathing (SDB). In summary, linear and non-linear analysis of HRV are reliable approaches to assess changes of autonomic cardiac modulation during sleep both in health and diseases. The use of these tools could provide important information of clinical and prognostic relevance.
Towards an improved and personalized risk stratification of sudden cardiac death in dilated non-ischaemic cardiomyopathy: is the time for ejection fraction coming to an end? (2021)

This editorial refers to ‘Ring-like late gadolinium enhancement for predicting ventricular tachyarrhythmias in nonischemic dilated cardiomyopathy’, by W. Chen et al. pp. 1130--8. Dilated non-ischaemic cardiomyopathy (NIDCM) is one of the most common cardiomyopathies with an estimated prevalence in the range of 1–2 in 400 individuals.1 Ventricular arrhythmias (VA) manifesting as sudden cardiac death (SCD) are one of the main causes of death in this population. Still, the accuracy of arrhythmia risk stratification for primary prevention of SCD in NIDCM remains suboptimal. Left ventricular ejection fraction (LVEF) is currently the key variable for identifying patients at higher risk. According to current guidelines, NIDCM patients with LVEF <35% would be at high risk of SCD and would warrant an implantable cardioverter-defibrillator (ICD).2 Unfortunately, this LVEF-based approach offers a low-positive predictive value. In the recently published DANISH study (Danish Study to Assess the Efficacy of ICD in Patients With Non-Ischemic...
An SNMP Agent for a DTV Data Server (2001)

This paper presents a framework for remote control and monitoring of a DTV data server using the Simple Network Management Protocol (SNMP). This standards-based framework consists of a remote manager, agent(s) that access the properties of the data server, and a management protocol that specifies the format of transfer of information between agents and the manager. The information to be accessed by the agent is provided in the form of a Management Information Base (MIB). We describe the process of developing a MIB for a generic DTV data server. The SNMP framework clearly separates management of the data server from the function of data serving, and also facilitates a consistent user interface to monitor and control diverse sub-systems in a broadcast plant, possibly provided by different vendors.
Supplemental Figure 7 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

Supplemental Figure 7 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Beyond Single-shot Text Queries: Bridging the Gap(s) between Research Communities (MindTheGap'14) (2014)

This workshop brings together researchers from different streams and communities that deal with information access in the widest sense. The general goal is to foster collaboration between the different communities and to showcase research that sits at the border between different areas of research.
Gas ionization induced by a high speed plasma injection in space (1986)

Gas ionization induced by a fast plasma injection has been observed with the Space Experiments with Particle Accelerators (SEPAC) Experiment on Spacelab‐1. When an impulsive high‐density plasma was injected from the orbiter, waves near the lower‐hybrid frequency were enhanced, and the surrounding gas drifting with the orbiter was ionized for several tens of milliseconds after the plasma injection. The long‐duration gas ionization was observed only when the plasma flux incoming to the orbiter cargo bay and the orbital velocity perpendicular to the magnetic field were relatively large. This effect has been explained by the concept of critical velocity ionization (CVI) for the gas drifting with the orbiter, although the gas velocity perpendicular to the magnetic field was less than the Alfvén critical velocity.
Adiponectin und Leptin: postprandialer Verlauf und die Beziehungen zu den Parametern der Insulin-Glukose-Homöostase in verschiedenen Glukosetoleranzstadien (2003)

Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients with Hip Fracture
Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. (1995)

Eotaxin is a member of the C-C family of chemokines and is related during antigen challenge in a guinea pig model of allergic airway inflammation (asthma). Consistent with its putative role in eosinophilic inflammation, eotaxin induces the selective infiltration of eosinophils when injected into the lung and skin. Using a guinea pig lung cDNA library, we have cloned full-length eotaxin cDNA. The cDNA encodes a protein of 96 amino acids, including a putative 23-amino acid hydrophobic leader sequence, followed by 73 amino acids composing the mature active eotaxin protein. The protein-coding region of this cDNA is 73, 71, 50, and 48% identical in nucleic acid sequence to those of human macrophage chemoattractant protein (MCP) 3, MCP-1, macrophage inflammatory protein (MIP) 1 alpha, and RANTES, respectively. Analysis of genomic DNA suggested that there is a single eotaxin gene in guinea pig which is apparently conserved in mice. High constitutive levels of eotaxin mRNA expression were observed in the lung, while the intestines, stomach, spleen, liver, heart, thymus, testes, and kidney expressed lower levels. To determine if eotaxin mRNA levels are elevated during allergen-induced eosinophilic airway inflammation, ovalbumin (OVA)-sensitized guinea pigs were challenged with aerosolized antigen. Compared with the lungs from saline-challenged animals, eotaxin mRNA levels increased sixfold within 3 h and returned to baseline by 6 h. Thus, eotaxin mRNA levels are increased in response to allergen challenge during the late phase response. The identification of constitutive eotaxin mRNA expression in multiple tissues suggests that in addition to regulating airway eosinophilia, eotaxin is likely to be involved in eosinophil recruitment into other tissues as well as in baseline tissue homing.
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways (2012)

The ubiquitin E3 ligase SIAH2 is an important regulator of the hypoxic response as it leads to the ubiquitin/proteasomal degradation of prolyl hydroxylases such as PHD3, which in turn increases the stability of hypoxia-inducible factor (HIF)-1α. In the present study, we identify the serine/threonine kinase DYRK2 as SIAH2 interaction partner that phosphorylates SIAH2 at five residues (Ser16, Thr26, Ser28, Ser68, and Thr119). Phosphomimetic and phospho-mutant forms of SIAH2 exhibit different subcellular localizations and consequently change in PHD3 degrading activity. Accordingly, phosphorylated SIAH2 is more active than the wild-type E3 ligase and shows an increased ability to trigger the HIF-1α-mediated transcriptional response and angiogenesis. We also found that SIAH2 knockdown increases DYRK2 stability, whereas SIAH2 expression facilitates DYRK2 polyubiquitination and degradation. Hypoxic conditions cause a SIAH2-dependent DYRK2 polyubiquitination and degradation which ultimately also results in an impaired SIAH2 phosphorylation. Similarly, DYRK2-mediated phosphorylation of p53 at Ser46 is impaired under hypoxic conditions, suggesting a molecular mechanism underlying chemotherapy resistance in solid tumors.
ChemInform Abstract: Reaction Sintering of Polycarbosilane‐Impregnated Compact of Silicon Carbide Hollow Particles and the Resultant Thermoelectric Properties. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure S2 from Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells (2023)

&lt;p&gt;Supplementary Figure S2 depicts quantification of S phase duration using EdU labelling in ovarian cancer cell lines.&lt;/p&gt;
Engineering electronic structure to prolong relaxation times in molecular qubits by minimising orbital angular momentum (2019)

The proposal that paramagnetic transition metal complexes could be used as qubits for quantum information processing (QIP) requires that the molecules retain the spin information for a sufficient length of time to allow computation and error correction. Therefore, understanding how the electron spin-lattice relaxation time (T<sub>1</sub>) and phase memory time (T<sub>m</sub>) relate to structure is important. Previous studies have focused on the ligand shell surrounding the paramagnetic centre, seeking to increase rigidity or remove elements with nuclear spins or both. Here we have studied a family of early 3d or 4f metals in the +2 oxidation states where the ground state is effectively a <sup>2</sup>S state. This leads to a highly isotropic spin and hence makes the putative qubit insensitive to its environment. We have studied how this influences T<sub>1</sub> and T<sub>m</sub> and show unusually long relaxation times given that the ligand shell is rich in nuclear spins and non-rigid.
Sevelamer carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on hemodialysis (2008)

Sevelamer carbonate is an anion exchange pharmaceutical, developed to improve on the performance of the non-absorbable, non-calcium, and metal-free phosphate binder sevelamer hydrochloride. Sevelamer carbonate is expected not to worsen metabolic acidosis, as previously reported during long-term treatment with sevelamer hydrochloride in hemodialysis (HD) patients. Carbonate is the alternate counterion to chloride on the sevelamer polymeric backbone, but the active poly(allylamine) responsible for phosphate (PO₄) binding remains unaltered. Therefore, sevelamer carbonate is expected to reduce elevated serum phosphorus level, similarly to sevelamer hydrochloride. Sevelamers are prescribed in uremic HD patients to control hyperphosphatemia, but the carbonate has also been proposed for the treatment of chronic kidney disease (CKD) non-dialysis patients. Although hyperphosphatemia is regarded as a main contributor to increased mortality in the HD population because of cardiovascular calcification, metabolic acidosis has also been advocated as a major player in the increased mortality in this population, by engendering malnutrition, negative nitrogen balance, and inflammation. This paper reviews the evidence showing that sevelamer carbonate is as good as sevelamer hydrochloride in terms of hyperphosphatemia control in CKD, but with a better outcome in serum bicarbonate balance.
Changes In The Primary Fibrinolysis Inhibitor (α2-Antiplasmin) After Cardio-Pulmonary Bypass (1981)

The blood level of the primary fibrinolysis inhibitor (PFI) has been reported to be relatively unchanged in most clinical conditions. However, we have found a strong increase 2-7 days after trauma in the form of this inhibitor (PFIα) with high affinity to plasminogen whereas the form with no or weak affinity to plasminogen (PFIβ) is not increased. The increase of PFIα may be due to increased synthesis in the liver. The method used for the measurement of the two forms is a two-step affinity chromatography using lysine- and plasminogen-Sepharose, respectively. In the present investigation we have studied the serum level of the two forms before and after the cardio-puhnonary bypass in 14 patients operated upon for cardiac surgery. Four patients had a blood loss of more than 1000 ml during the first 16 hours after bypass (group 1)6 patients lost between 500-1000 ml (group II) and 4 patients lost less than 500 ml (group III). PFIα was significantly lower and PFIβ was significantly higher in group I than in groups II and III. One patient with the largest blood loss showed the strongest decrease (30 % of normal value) in PFIα in the whole material and the strongest increase in PFIβ (160 %). This patient also had the lowest level of plasminogen activators and plasminogen. The reason for the decreased level of PFIα in the patients with heavy bleeding may be a consumption and the increase in PFIβ suggests that this form may be a degradation product of PFIα.
Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations (2021)

Our study provides evidence that GMP represents a promising dietary nutraceutical in view of its beneficial regulation of systemic insulin resistance and hepatic insulin signaling pathway, likely via its powerful antioxidant and anti-inflammatory properties.
Testing predictions of small brood models using parasitoid wasps (2005)

Question: How is variation in offspring size (between broods) related to brood size? Hypotheses: Variance in offspring size (between broods) should decrease with increasing brood size as predicted by Charnov and colleagues' (Charnov and Downhower, 1995; Charnov et al., 1995) small brood invariant. The range in resources put towards reproduction (for mothers producing a certain brood size) should be invariant over brood size (Downhower and Charnov, 1998). We also test assumptions underlying these predictions. Data studied: We use previously collected data on six parasitoid wasp species. Conclusions: As predicted, variance in offspring size among broods decreased with increasing brood size. However, this decrease did not follow closely the quantitative predictions of Charnov and colleagues (Charnov and Downhower, 1995; Charnov et al., 1995). We found some support for the prediction that the range in resources invested in reproduction is invariant over brood size. The assumption that mean offspring size is constant over brood size was violated in three of six species. The assumpt [KEYWORDS: brood size ; litter size ; parasitoid wasps ; resource allocation ; trade-off OPTIMAL OFFSPRING SIZE ; CLUTCH-SIZE ; SEX-CHANGE ; BODY-SIZE ; HYMENOPTERA ; EVOLUTION ; FITNESS ; FIELD ; INVARIANTS ; EULOPHIDAE]
The requirement of light chain for the surface deposition of the heavy chain of immunoglobulin M. (1983)

The murine tumor line 70Z/3 resembles a pre-B lymphocyte in containing the heavy chain of IgM (mu) as a cytoplasmic protein in the apparent absence of light chain (L). However, these cells can be induced by lipopolysaccharide to differentiate into a B lymphocyte-like state, containing mu2L2 tetramers as membrane-bound molecules. This is a accompanied by an increase in mu synthesis, the acquisition of complex carbohydrate by mu, and the induction of L chain. We wished to determine which of these events is critical for membrane deposition of mu. We found that uninduced 70Z/3 cells, as well as lipopolysaccharide-uninducible variants, contained a low, constitutive level of membrane bound mu, all of which was found as mu2L2. Dextran sulfate, another inducing agent, apparently caused a redistribution of this pre-existing surface mu without altering the pattern of mu synthesis or processing. One lipopolysaccharide-uninducible variant showed a small subset of surface mu-positive cells, and the proportion of these cells increased with a prolonged induction period. The increase in mu synthesis was nearly normal, but mu did not acquire complex carbohydrate. However, the delayed appearance of surface mu-positive cells was paralleled by a delayed increase in L chain, which occurred only in those cells with mu on their membrane. We concluded that L chain signals the transport of mu to the cell surface.
Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: Effect of liver transplantation (2000)

Diabetes mellitus frequently complicates cirrhosis but the pathogenic mechanisms are unknown. To assess the contribution of reduced insulin action and secretion, 24 cirrhotic-diabetic patients waiting for liver transplant because of an unresectable hepatocarcinoma underwent an oral glucose tolerance test (OGTT) to assess the beta-cell function and an insulin clamp combined with [3-(3)H]glucose infusion to measure whole body glucose metabolism before and 2 years after the transplant. Seven cirrhotic nondiabetic patients, 11 patients with chronic uveitis on similar immunosuppressive therapy, and 7 healthy subjects served as control groups. Cirrhotic patients showed a profound insulin resistance, and diabetics in addition also showed increased endogenous glucose production (P <.05) and insulin deficiency during the OGTT (P <.05). Liver transplantation normalized endogenous glucose production and insulin sensitivity but failed to cure diabetes in 8 of the 24 patients because a markedly low insulin response during the OGTT. Age, body mass index, family history of diabetes, immunosuppressive drugs, and pathogenesis of cirrhosis did not predict in whom liver transplant was going to cure diabetes. On the contrary, a reduced secretory response characterized the patients in whom the transplant would not be curative. In summary, insulin resistance was a primary event complicating cirrhosis but additional beta-cell secretory defects were crucial for development of diabetes. Liver transplantation, lessening insulin resistance, cured hepatogenous diabetes in 67% of cirrhotic-diabetic patients; nevertheless 33% were still diabetics because the persistence of a reduced beta-cell function, which makes these patients eventually eligible for combined islet transplantation.
Targeted LC–MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA (2010)

Based on the template of a recently introduced derivatization reagent for aldehydes, 4-(2-(trimethylammonio)ethoxy)benzeneaminium dibromide (4-APC), a new derivatization agent was designed with additional features for the analysis and screening of biomarkers of lipid peroxidation. The new derivatization reagent, 4-(2-((4-bromophenethyl)dimethylammonio)ethoxy)benzenaminium dibromide (4-APEBA) contains a bromophenethyl group to incorporate an isotopic signature to the derivatives and to add additional fragmentation identifiers, collectively enhancing the abilities for detection and screening of unknown aldehydes. Derivatization can be achieved under mild conditions (pH 5.7, 10 degrees C). By changing the secondary reagent (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide instead of sodium cyanoborohydride), 4-APEBA is also applicable to the selective derivatization of carboxylic acids. Synthesis of the new label, exploration of the derivatization conditions, characterization of the fragmentation of the aldehyde and carboxylic acid derivatives in MS/MS, and preliminary applications of the labeling strategy for the analysis of aldehydes in urine and plasma are described.
A New Ignition Delay Formulation Applied to Predict Misfiring During Cold Starting of Diesel Engines (2000)

&lt;div class="htmlview paragraph"&gt;A new formulation is developed for the ignition delay (ID) in diesel engines to account for the effect of piston motion on the global autoignition reaction rates. A differentiation is made between the ID&lt;sub&gt;e&lt;/sub&gt; measured in engines and ID&lt;sub&gt;v&lt;/sub&gt;, measured in constant volume vessels. In addition, a method is presented to determine the coefficients of the ID&lt;sub&gt;e&lt;/sub&gt; correlation from actual engine experimental data. The new formulation for ID&lt;sub&gt;e&lt;/sub&gt; is applied to predict the misfiring cycles during the cold starting of diesel engines at different low ambient temperatures. The predictions are compared with experimental results obtained on a multi-cylinder heavy-duty diesel engine.&lt;/div&gt;
Deprotonation, insertion and isomerisation in the post-functionalisation of tris-pyridyl aluminates (2019)

Post-functionalisation of the aluminate anion [EtAl(6-R-2-py)3]- (6-R-2-py = 6-R-2-pyridyl, R = Me or Br) can be accomplished via nucleophilic addition of the pyridyl groups to the electrophilic C[double bond, length as m-dash]O group of aldehydes (RCH[double bond, length as m-dash]O) or by deprotonation of carboxylic acids (RCO2H). NMR spectroscopic and crystallographic studies show how 6-Me-2-py groups can detect chirality and reveal a new aspect of isomerism.
Detection of Insulin Production by Immunohistochemistry (2003)

Detection of insulin by immunocytochemistry is one of the most powerful and sensitive techniques available to monitor levels of expression in islets (), β-cells in culture (), tissue samples (), and cells transgenically expressing the insulin gene (). Like all immunocytochemistry techniques, much depends on the availability of a high-quality primary antibody. Species-specific insulin antibodies are now available from a number of commercial sources (including Santa Cruz), and these allow sensitive and specific detection of even very low levels of expression. Described below is the protocol for detection of insulin in β-cell lines in culture, using a FITC-coupled secondary antibody. A broad range of secondary antibodies are also available, including fluorescein isothiocyanate (FITC), tetramethylrhodamine isothiocyanate (TRITC), and biotin-labeling, among others. For cells in culture, two-well, four-well, or eight-well chamber slides are recommended (available from several commercial sources, including Nunc), as these allow rapid and simple processing of large numbers of replicate samples, with small volumes of antibody. However, the following protocol can also be applied to cells grown on coated cover slips. The methods described here are for analysis by fluorescence microscopy. For analysis of insulin expression in intact islets, confocal microscopy would be required ().
Hypochlorous Acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. (2014)

The stabilized HOCl solution had dose-dependent favorable effects on fibroblast and keratinocyte migration compared to povidone iodine and media alone. These features lead to a stabilized HOCl solution as an ideal wound care agent.