gebhart/patrepeval huggingface dataset:
TOBF1 modulates mouse embryonic stem cell fate through co-transcriptional regulation of alternative splicing (2023)

Abstract Embryonic stem (ES) cells retain the ability to undergo lineage-specific differentiation that can eventually give rise to different cell types that constitute an organism. Although stem cell specific biological networks of transcription factors and epigenetic modifiers are well established, how the ES cell specific transcriptional and alternative splicing (AS) machinery regulate their expression has not been sufficiently explored. In this study, we show that the lncRNA associated protein TOBF1 regulates the co-transcriptional alternative splicing of transcripts necessary for maintaining stem cell identity in mouse ES cells. Overlaying information derived from TOBF1 chromatin occupancy, the distribution of its pluripotency-associated OCT-SOX binding motifs, and transcripts undergoing differential expression and alternative splicing upon its disruption unmasked local nuclear territories where these distinct events converge, ultimately leading to the maintenance of mouse ES cell identity.
Synthesis, characterization and corrosion inhibition efficiency of 2-(6-methylpyridin-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline on mild steel in sulphuric acid (2010)

Phenanthroline derivative, 2-(6-methylpyridin-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline (MIP) was synthesized and characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, and single crystal X-ray diffraction study. MIP was evaluated as corrosion inhibitor for mild steel in 0.5 M H2SO4 solution using gravimetric and UV–Visible spectrophotometric methods at 303–333 K. Results obtained show that MIP acts as inhibitor for mild steel in H2SO4 solution. The inhibition efficiency was found to increase with increase in MIP concentration but decreased with temperature. Activation parameters and Gibbs free energy for the adsorption process using statistical physics were calculated and discussed. The UV–Visible absorption spectra of the solution containing the inhibitor after the immersion of mild steel specimen indicate the formation of a MIP-Fe complex.
Lack of Association of Small-Colony-Variant Staphylococcus aureus Strains with Long-Term Use of Azithromycin in Patients with Cystic Fibrosis (2011)

There are increasing reports of small-colony-variant (SCV) strains of Staphylococcus aureus in patients with cystic fibrosis (CF) ([4][1]). In CF, azithromycin has been associated with the emergence of hypermutable strains ([2][2]), which also have increased antimicrobial resistance ([1][3]). SCV
Bounded output feedback control of the Kuramoto-Sivashinsky equation with input constraints (2001)

This work focuses on the stabilization of the equation of Kuramoto et al. (1975, 1976) and Sivashinsky (1977) [KSE] with periodic boundary conditions at the zero solution in the presence of input constraints. Bounded nonlinear stabilizing controllers are synthesized on the basis of finite-dimensional Galerkin approximations of the KSE which capture the dominant dynamics of the equation for a given value of the instability parameter. The controller design accounts explicitly for the presence of input constraints and an explicit characterization of the limitations imposed by the input constraints on the allowable control actuator locations is provided. The theoretical results are successfully illustrated through computer simulations of the closed-loop system using a high-order discretization of the KSE.
CloudLens, un langage de script pour l'analyse de données semi-structurées (2017)

International audience
Information fusion for wireless sensor networks (2007)

Wireless sensor networks produce a large amount of data that needs to be processed, delivered, and assessed according to the application objectives. The way these data are manipulated by the sensor nodes is a fundamental issue. Information fusion arises as a response to process data gathered by sensor nodes and benefits from their processing capability. By exploiting the synergy among the available data, information fusion techniques can reduce the amount of data traffic, filter noisy measurements, and make predictions and inferences about a monitored entity. In this work, we survey the current state-of-the-art of information fusion by presenting the known methods, algorithms, architectures, and models of information fusion, and discuss their applicability in the context of wireless sensor networks.
Bio-mimic energy storage system with solar light conversion to hydrogen by combination of photovoltaic devices and electrochemical cells inspired by the antenna-associated photosystem II (2020)

Global warming caused by anthropogenic activity is one of the serious problems today. In order to suppress the global warming, the shift from fossil fuel-based energy source to the nature-oriented sustainable energy is encouraged. In this concept paper, possible biomimetic engineering approach inspired by the efficient and sustainable natural energy utilization in living plants is demonstrated. The focal features in plants include (1) the light-harvesting and energy condensing apparatus, (2) water splitting O<sub>2</sub> evolving apparatus, (3) storage of energy-related chemicals, and (4) reversal conversion of storage into the "energy in use" by meeting the demands. Demonstration of solar-driven chemical energy conversion was performed using a system consisted of (i) photovoltaic power-generating device, (ii) an electrochemical unit converting electric power into chemical energy, (iii) storage of H<sub>2</sub>, and (iv) polymer electrolyte cells converting H<sub>2</sub> back to electricity by meeting the demands on site. The present concept paper presenting a technical perspective based on the plant-inspired knowledge (conceptual similarity between natural photosynthesis and solar-to-H<sub>2</sub> conversion) is a fruit of interdisciplinary collaboration between the team of chemical energy conversion renown for the world highest record of solar-to-hydrogen conversion efficiency (24.4%, as of 2015) and a group of plant biologists.
Design enhancement of a solid ankle-foot orthosis: real-time contact pressures evaluation. (2000)

The purpose of our study was to evaluate all contact pressures between the molded ankle-foot orthosis (MAFO) and the subject during activities of daily living. The MAFOs studied are used clinically to reduce plantar contact pressures associated with foot ulcers in adult neuropathic diabetic subjects, alleviating abnormal pressures by redistributing them to low-pressure plantar regions. While effective, MAFOs are often not used by the subject due to weight and comfort issues. An understanding of the contact pressures between the subject and the orthosis is a first step in improving basic MAFO design. Four nonimpaired, young adult males were tested in this study. A right-side MAFO was custom-molded and fitted for each subject by the same orthotist. Real-time pressures were obtained for the entire contact area using the F-Scan pressure measurement system. The data obtained demonstrated high contact pressures along the metatarsals of the foot, around the heel and ankle, and adjacent to the strap attachment sites. No contact pressures were noted along the posterior calf region during any of the activities performed. These data suggest the calf region would be a suitable site for material removal for weight reduction and increased comfort, especially in warm weather. In addition, these data may be useful to orthotists in improving the basic design and to researchers as a starting point for performing complex finite element analysis on the MAFO.
Adaptive importance sampling for multi-ray gathering (2011)

We present an adaptive noise reduction technique for integrating incident radiance at a fixed position. We use a Russian-roulette-based importance sampler to reshape the directional probability density of future rays in a batch, based on an affinity map that incorporates ratings of evaluated rays, provided by the rendering engine. Our method is unbiased, has low overhead, requires no precomputation, and works in concert with other importance sampling schemes.
Developing Integrated Envelope and Lighting Systems for Commercial Buildings (1994)

Integrated envelope and lighting systems achieve significant energy, peak demand, and cost savings over typical component-by-component design practice by leveraging the interactive energy balance between electric lighting energy use and cooling due to lighting and solar radiation.We discuss how these savings can be achieved using conventional glazing and lighting components by taking an integrated systems design approach.We describe integrated dynamic envelope and lighting systems, currently under development, that actively achieve this energy balance through the use of intelligent control systems.We show how prototypical daylighting systems can be used to increase the efficacy and distribution of daylight throughout the space for the same or less glazing area as a typical window, while achieving greater energy savings with increased visual comfort.Energy performance simulations and field tests conducted to date illustrate significant energy savings, peak demand reductions, and potential practical implementation of these proposed systems.
LogLens: A Real-Time Log Analysis System (2018)

Administrators of most user-facing systems depend on periodic log data to get an idea of the health and status of production applications. Logs report information, which is crucial to diagnose the root cause of complex problems. In this paper, we present a real-time log analysis system called LogLens that automates the process of anomaly detection from logs with no (or minimal) target system knowledge and user specification. In LogLens, we employ unsupervised machine learning based techniques to discover patterns in application logs, and then leverage these patterns along with the real-time log parsing for designing advanced log analytics applications. Compared to the existing systems which are primarily limited to log indexing and search capabilities, LogLens presents an extensible system for supporting both stateless and stateful log analysis applications. Currently, LogLens is running at the core of a commercial log analysis solution handling millions of logs generated from the large-scale industrial environments and reported up to 12096x man-hours reduction in troubleshooting operational problems compared to the manual approach.
Comparison of AlN Encapsulants for Bulk GaN Multicycle Rapid Thermal Annealing (2015)

Sputtered AlN capping layers deposited at different temperatures were compared for their efficacy in protecting bulk GaN substrates during high temperature annealing. AlN sputtered at a substrate temperature of 400°C on the epi-ready surface of bulk GaN cracked due to the strain associated with the lattice mismatch between AlN and GaN. AlN caps sputtered on the rougher optically-polished surface did not crack due to strain relief that results from polishing damage. During heating pulses with a maximum temperature of 1400°C, the exposed GaN in the cracked regions was damaged due to GaN decomposition. In contrast, AlN capping layers deposited at room temperature did not exhibit cracking since this condition energetically prevents the AlN from orienting to the GaN surface and forming cracks. Even after 20 rapid heating cycles with a maximum temperature of 1400°C, the GaN surface remains very smooth (0.70 nm RMS) over a 350 μm × 260 μm area. The ability to anneal bulk GaN at high temperatures without surface degradation using the AlN cap developed herein is a critical processing step that will enable planar processing for future vertical III-nitride devices.
Magma fuel cell. [For energy extraction from magma or for electrochemical protection of heat exchangers in magma] (1975)

A high temperature, solid-electrolyte fuel cell is described which uses molten rock having oxidizable constituents as a fuel. The principles of this magma fuel cell have been successfully demonstrated and power densities of 88 W/m/sup 2/ have been achieved. If power densities can be substantially increased, the magma fuel cell may find numerous applications in magma tap projects to increase the efficiency of energy extraction from magma sources or may provide the energy necessary for the electrochemical protection of the heat exchanger materials placed in the corrosive magma environment.
The Taming of Redox‐Labile Phosphidotitanocene Cations (2018)

Tame d<sup>0</sup> phosphidotitanocene cations stabilized with a pendant tertiary phosphane arm are reported. These compounds were obtained by one-electron oxidation of d<sup>1</sup> precursors with [Cp<sub>2</sub> Fe][BPh<sub>4</sub> ]. The electronic structure of these compounds was studied experimentally (EPR, UV/Vis, and NMR spectroscopy, X-ray diffraction analysis) and through DFT calculations. The theoretical analysis of the bonding situation by using the electron localization function (ELF) shows the presence of π-interactions between the phosphido ligand and Ti in the d<sup>0</sup> complexes, whereas dπ-pπ repulsion prevents such interactions in the d<sup>1</sup> complexes. In addition, CH-π interactions were observed in several complexes, both in solution and in the solid state, between the phosphido ligand and the phosphane arm. The d<sup>0</sup> complexes were found to be light sensitive, and decompose through Ti-P bond homolysis to give Ti<sup>III</sup> species. A naked d<sup>0</sup> phosphidotitanocene cation has been trapped by reaction with diphenylacetylene, yielding a Ti/P frustrated Lewis pair (FLP), which was found to be less reactive than a previously reported Zr analog.
A Clinical Perspective of Anti-Fibrotic Therapies for Cardiovascular Disease (2017)

Cardiac fibrosis are central to various cardiovascular diseases. Research on the mechanisms and therapeutic targets for cardiac fibrosis has advanced greatly in recent years. However, while many anti-fibrotic treatments have been studied in animal models and seem promising, translation of experimental findings into human patients has been rather limited. Thus, several potential new treatments which have shown to reduce cardiac fibrosis in animal models have either not been tested in humans or proved to be disappointing in clinical trials. A majority of clinical studies are of small size or have not been maintained for long enough periods. In addition, although some conventional therapies, such as renin-angiotensin-aldosterone system (RAAS) inhibitors, have been shown to reduce cardiac fibrosis in humans, cardiac fibrosis persists in patients with heart failure even when treated with these conventional therapies, indicating a need to develop novel and effective anti-fibrotic therapies in cardiovascular disease. In this review article, we summarize anti-fibrotic therapies for cardiovascular disease in humans, discuss the limitations of currently used therapies, along with possible reasons for the failure of so many anti-fibrotic drugs at the clinical level. We will then explore the future directions of anti-fibrotic therapies on cardiovascular disease, and this will include emerging anti-fibrotics that show promise, such as relaxin. A better understanding of the differences between animal models and human pathology, and improved insight into carefully designed trials on appropriate end-points and appropriate dosing need to be considered to identify more effective anti-fibrotics for treating cardiovascular fibrosis in human patients.
Authentic Versus Counterfeit Image Classification after Re-Sampling and Compression (2010)

Image-based applications such as inspection, quality assurance, print quality assessment, and authentication are often bandwidth limited, and benefit from image down-sampling or compression. Often the down-sampling or compression strategy is selected without considering the impact on the functional goal of the imaging task. In this paper, we use a specific "functional" imaging application&#x2013;the distinction between images of authentic products and counterfeit products&#x2013;to assess the impact of down-sampling and compression on the classification accuracy of the counterfeit detection imaging software. Our samples are originally scanned at high resolution (600 dots/in, or dpi) and then down-sampled to as little as 10 ppi (continuous tone pixels/in). JPEG compression to 2% and 1% of the original image size were performed separately or in combination with the various down-sampling factors. A simple Gaussian classifier was used throughout. We found that improved classification accuracy was obtained even for samples compressed or down-sampled by more than 99%. The implications of these findings for improved inspection results, authentication accuracy and counterfeit detection are then discussed.
[Multiple myeloma with massive ascites fluid--immunophenotypic analysis of myeloma cell and its IL-6-dependent growth]. (1994)

A 75-year-old female was diagnosed as having multiple myeloma (IgG.lambda type. Stage IIA) with plasmacytoma of the head and back in October, 1989. She obtained partial remission by MCNU and MP therapy, but relapsed with massive ascites in January, 1991. VAD therapy was not effective and she died of multiple organ failure on February 23. Her ascites contained a large number of myeloma cells, and the phenotypic analysis and the response to interleukin-6 (IL-6) of these myeloma cells were examined. The myeloma cells were positive for CD33, CD45, CD45RA, CD63, CD71, plasma cell associated antigens such as CD38, PCA-1, BL3, and various kinds of adhesion molecules: CD11a/CD18 (LFA-1), CD29 (VLA-beta 1), CD44 (H-CAM), CD49d (VLA-4), CD54 (ICAM-1), CD56 (N-CAM), CD58 (LFA-3). IL-6 level in the ascites was increased at 91.0pg/ml. The myeloma cells showed an IL-6 dependent growth, which was inhibited by anti-IL-6 antibody (Ab) and anti-IL-6 receptor Ab in vitro. Myeloma cells appearing in ascites have rarely been reported. Our case suggested that IL-6 was a potent growth factor of myeloma cells through an autocrine mechanism in the ascites, and resulted in an aggressive myeloma.
Improved Mechanical Properties by Nanoreinforced Ceramic Composite HVOF Coatings (2006)

Special nanoreinforced ceramic composite coatings were produced. Dense nanostructured alumina and chromia coatings alloyed with various nanofraction elements such as Ni, NiO, ZrO2 and SiC were manufactured by HV2000 HVOF spraying. As a result coatings with nearly 100% improvements relative fracture toughness, were produced.
Emission Reduction Device for SULEV Vehicle Applications (2004)

<div class="htmlview paragraph">This paper describes a cold start emission reduction system developed for a 3.0L V6 test vehicle in order to meet SULEV emission regulations. The emphasis of this research is how the system can be used to meet SULEV emission standards without the need for a heavily loaded catalyst. A fuel-vaporizing device has been developed that generates vaporized fuel to be consumed during engine start up. The device allows for lean A/F ratio control during engine start and idle and is called a Combustion Stabilizing Device (CSD). A vehicle with a CSD mounted to the engine was tested in an emission lab. The test vehicle resulted in approximately 50% HC emission reduction in the first 20s of engine startup and had a catalyst warm-up time to T<sub>50</sub> (50% converter efficiency) of less than 20s.</div>
Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon (2006)

The anesthetic properties of xenon have been known for more than 50 yr, and the safety and efficacy of xenon inhalational anesthesia has been demonstrated in several recent clinical studies. In addition, xenon demonstrates many favorable pharmacodynamic and pharmacokinetic properties, which could be used in certain niche clinical settings such as cardiopulmonary bypass. This inert gas is capable of interacting with a variety of molecular targets, and some of them are also modulated in anesthesia-relevant brain regions. Besides these anesthetic and analgesic effects, xenon has been shown to exert substantial organoprotective properties, especially in the brain and the heart. Several experimental studies have demonstrated a reduction in cerebral and myocardial infarction after xenon application. Whether this translates to a clinical benefit must be determined because preservation of myocardial and cerebral function may outweigh the significant cost of xenon administration. Clinical trials to assess the impact of xenon in settings with a high probability of injury such as cardiopulmonary bypass and neonatal asphyxia should be designed and underpinned with investigation of the molecular targets that transduce these effects.
Measuring two dimensional strain state of AlN quantum dots in GaN nanowires by nanobeam electron diffraction (2011)

Nanobeam electron diffraction (NBED or NBD) is a transmission electron microscope (TEM) based technique able to measure strain with nanometre spatial resolution. This technique is especially well designed for nanostructures as reference diffraction pattern can be acquired anywhere on the sample. NBED is here applied on AlN/GaN superlattices grown on SiC and results compared to finite element simulations in order to assess the accuracy of the method. Strain profiles were then acquired with success on GaN nanowires presenting 3 nm GaN inclusions separated by 3 nm thick AlN.
KLINISCHE ERFAHRUNGEN ZUR BESTIMMUNG VON BLUTLAKTAT NACH DEM ENZYMATISCHELEKTROCHEMISCHEN PRINZIP (LACTATE ANALYZER 640) (1977)

Article KLINISCHE ERFAHRUNGEN ZUR BESTIMMUNG VON BLUTLAKTAT NACH DEM ENZYMATISCHELEKTROCHEMISCHEN PRINZIP (LACTATE ANALYZER 640) was published on January 1, 1977 in the journal Biomedical Engineering / Biomedizinische Technik (volume 22, issue s1).
Revised model of thermally stimulated current in MOS capacitors (1997)

It is shown analytically and experimentally that, when significant densities of positive and/or negative charge are trapped in the bulk of the oxide, standard thermally stimulated current (TSC) measurements at negative gate bias may not provide accurate estimates of MOS oxide-trap charge densities. Combining TSC measurements at negative bias with capacitance-voltage (C-V) measurements allows useful, self-consistent estimates of trapped electron densities in the oxide to be obtained. However, unless one can determine whether most of the trapped electrons lie in the bulk of the oxide or in border traps, unambiguous estimates of trapped positive charge densities cannot be obtained with negative or positive bias TSC, with or without C-V measurements. Implications are discussed for charge trapping in radiation-hardened thermal oxides, SIMOX buried oxides, and bipolar base oxides.
Supplementary Figure 5 from Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts (2023)

Supplementary Figure 5 from Tumor-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
EFFECT OF IN-VEHICLE DRIVER INFORMATION SYSTEMS ON DRIVING PERFORMANCE: SIMULATION STUDIES (1994)

Driving simulation studies have been conducted to evaluate driver distraction for a range of in-vehicle route guidance devices. While the initial simulations showed generally improved driving performance with virtually all electronic devices in comparison to a paper map, the second set of simulation studies elicited even more lucid findings. Voice guidance and a revised heads-up display (compared to the first experiment) yielded shortest reaction times, lowest subjective workload and strongest user preferences. The electronic map also performed well but a heads-down guidance screen, identical to the heads-up display, performed worse among electronic devices. (A) For the covering abstract see IRRD 868006.