gebhart/patrepeval huggingface dataset:
The Cost-Effectiveness of Initial Treatment of Multiple Myeloma in the U.S. With Bortezomib Plus Melphalan and Prednisone Versus Thalidomide Plus Melphalan and Prednisone or Lenalidomide Plus Melphalan and Prednisone With Continuous Lenalidomide Maintenance Treatment (2013)

The outlook for transplant-ineligible multiple myeloma patients has improved enormously over recent years with the incorporation of new agents into standard regimens. Novel regimens combine melphalan and prednisone (MP) with bortezomib (VMP), with thalidomide (MPT), and with lenalidomide with (MPR-R) and without (MPR) lenalidomide maintenance. The efficacy, safety, and cost-effectiveness of these regimens have not yet been compared; therefore, we conducted a pharmacoeconomic analysis using data from randomized controlled trials versus MP. Using a Markov model developed from a U.S. payer's perspective, we compared VMP with MPT and MPR-R over a lifetime horizon. MPT and MPR-R were chosen because, like VMP, they are superior to MP in response and outcomes. Data from the Velcade as Initial Standard Therapy in Multiple Myeloma (VISTA; VMP), Intergroupe Francophone du Myelome (IFM) 99-06 (MPT), and MM-015 (MPR-R) trials were used. The IFM 99-06 study was selected because of the superior activity in this study compared with other MPT studies. Using patient-level (VMP) and published (MPT, MPR-R) data, we estimated the health-state transition and adverse event probabilities for each regimen, related costs, and state-specific utility estimates. Costs (in 2010 U.S. dollars) and health outcomes were discounted at 3%. Discounted lifetime direct medical costs were lowest with VMP at $119,102. MPT cost $142,452 whereas MPR-R cost $248,358. Incremental cost-effectiveness ratio calculations projected that VMP would confer cost savings and better health outcomes relative to MPT and MPR-R. We conclude that VMP is highly likely to be cost-effective compared with MP, MPT, and MPR-R.
Silicon Photonic Modulator Based on a MOS-Capacitor and a CMOS Driver (2014)

We describe a silicon photonic optical modulator based on a MOS-capacitor and a low power 1V CMOS inverter-based driver IC. In an MZI configuration, this efficient modulator and driver IC combination can produce a 9dB extinction ratio at 28 Gbps, at a wavelength of 1310nm.
[Analysis of lipoprotein metabolism in alcoholics]. (2008)

High density lipoprotein (HDL) is increased by exercise and drinking and is well known as a negative risk factor of coronary heart disease. We analyzed serum lipids of alcoholics from the view points of biochemical examination, remnant like particle (RLP) and particle size of lipoprotein for the purpose of estimated effect of serum lipids, especially HDL quality in alcoholics. Serum levels of total cholesterol, free glycerol, RLP-C and RLP-TG were significantly decreased after hospitalization. The condition of RLP-C/RLP-TG on admission revealed cholesterol-rich composition. In case of HDL-C, the longer period from last drinking to hospitalization affected its decrease. From analytical study of particle size of lipoprotein, quantities of HDL-C in very large size and large size were significantly decreased after hospitalization which means that HDL composition at hospitalization is cholesterol-rich. So, it is speculated that increased serum level of HDL in alcoholics may be caused by expanded cholesterol ester and its quality may be different from that of healthy people. In this meaning, the study of arteriosclerosis in alcoholics will be necessary in relation to high level of serum HDL-C.
IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS‐treated dendritic cells (2007)

We have previously shown that human monocyte-derived dendritic cells (DC) express indoleamine 2,3-dioxygenase (IDO), as well as several other enzymes of the kynurenine pathway at the mRNA level upon maturation. The tolerogenic mechanisms of this pathway remain unclear. Here we show that LPS-treated DC metabolize tryptophan as far as quinolinate. We found that IDO contributes to LPS and TNF-alpha + poly(I:C)-induced DC maturation since IDO inhibition using two different inhibitors impairs DC maturation. IDO knock-down using short-hairpin RNA also led to diminished LPS-induced maturation. In line with these results, the tryptophan-derived catabolites 3-hydroxyanthranilic acid and 3-hydroxykynurenine increased maturation of LPS-treated DC. Concerning the molecular mechanisms of this effect, IDO acts as an intermediate pathway in LPS-induced production of reactive oxygen species and NF-kappaB activation, two processes that lead to DC maturation. Finally, we show that mature DC expand CD4(+)CD25(high) regulatory T cells in an IDO-dependent manner. In conclusion, we show that IDO constitutes an intermediate pathway in DC maturation leading to expansion of CD4(+)CD25(high) regulatory T cells.
Phosphoproteins and Biomineralization (1999)

Phosphoproteins play multiple roles in regulating biomineralization. This paper reviews the data implicating bone and dentin phosphorylated proteins in this process, and provides data suggesting which protein domains may be important in the interaction with apatite mineral crystals.
Short-term forecasting of inertial response from a wind power plant (2016)

The total inertia stored in all rotating masses (synchronous generators, induction motors, etc.) connected to a power system grid is an essential force that keeps the system stable after disturbances. Power systems have been experiencing reduced inertia during the past few decades [1]. This trend will continue as the level of renewable generation (e.g., wind and solar) increases. Wind power plants (WPPs) and other renewable power plants with power electronic interfaces are capable of delivering frequency response (both droop and/or inertial response) by a control action; thus, the reduction in available online inertia can be compensated by designing the plant control to include frequency response. The source of energy to be delivered as inertial response is determined by the type of generation (wind, photovoltaic, concentrating solar power, etc.) and the control strategy chosen. The importance of providing ancillary services to ensure frequency control within a power system is evidenced from many recent publications with different perspectives (manufacturer, system operator, regulator, etc.) [2]-[6]. This paper is intended to provide operators with a method for the real-time assessment of the available inertia of a WPP. This is critical to managing power system stability and the reserve margin. In many states, modern WPPs are required to provide ancillary services (e.g., frequency regulation via governor response and inertial response) to the grid. This paper describes the method of estimating the available inertia and the profile of the forecasted response from a WPP.
Investigation of the Nanomechanical and Tribological Properties of Tooth-Fillings Materials (2007)

This study utilizes novel characterization techniques nanoindentation and nanoscratch for testing both the human enamel and dentine together with two biocompatible dental filling materials; epoxy nanocomposite and silver amalgam. Nanoindentation tests were performed to obtain accurate hardness and reduced modulus values for the enamel, dentin and two different fillers. We utilized Nano-scratch tests to obtain critical load in scratch test and resistance to sliding wear. Testing showed the silver amalgam filling has a higher modulus of elasticity, hardness and wear resistance compared to the nanocomposite. The novel mechanical characterization techniques utilized might assist in better understanding the mechanical behavior of the dental fillers and thus facilitate the design of robust fillers with excellent mechanical properties.
Leading the way in telehealth. (2012)

In a major win for nursing and midwifery, a formidable group joined forces in a submission to the Australian Government for funding to offer telehealth training and support for nurses and midwives. Led by the Australian Practice Nurses Association (APNA), the consortia consists of the ANF, CRANAplus, the Australian College of Nurse Practitioners and the Australian College of Midwives. In May the group was advised of their successful tender for the Telehealth Nursing and Midwifery: Support and Education Project.
Dynamic Optimum Dead Time in Piezoelectric Transformer-Based Switch-Mode Power Supplies (2016)

Soft switching is required to attain high efficiency in high-frequency power converters. Piezoelectric-transformer-based converters can benefit from soft switching in terms of significantly diminished switching losses and stresses. Adequate dead time is needed in order to deliver sufficient energy to charge and discharge the input capacitance of piezoelectric transformers in order to achieve zero-voltage switching. This paper proposes a method for detecting the optimum dead time in piezoelectric transformer-based switch-mode power supplies. The provision of sufficient dead time in every cycle of the switching period results in the quick start-up of resonant current inside the transformer. The new method is implemented by dynamically detecting the optimum dead time for each resonant cycle and results in reduced energy loss and, consequently, increased efficiency in the converter during initialization time and steady-state operation. The theory of optimum dead time operation is also discussed in this paper. Experimental results and simulation are provided to show the implementation of the concept.
Phosphorylation of Ser 1928 mediates the enhanced activity of the L-type Ca 2+ channel Ca v 1.2 by the β 2 -adrenergic receptor in neurons (2017)

The L-type Ca<sup>2+</sup> channel Ca<sub>v</sub>1.2 controls multiple functions throughout the body including heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses triggered by a signaling pathway involving β-adrenergic receptors (βARs), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA). PKA readily phosphorylates Ser<sup>1928</sup> in Ca<sub>v</sub>1.2 in vitro and in vivo, including in rodents and humans. However, S1928A knock-in (KI) mice have normal PKA-mediated L-type channel regulation in the heart, indicating that Ser<sup>1928</sup> is not required for regulation of cardiac Ca<sub>v</sub>1.2 by PKA in this tissue. We report that augmentation of L-type currents by PKA in neurons was absent in S1928A KI mice. Furthermore, S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Ca<sub>v</sub>1.2 and enhancement of its activity by the β<sub>2</sub>-adrenergic receptor (β<sub>2</sub>AR)-cAMP-PKA cascade. Thus, there is an unexpected dichotomy in the control of Ca<sub>v</sub>1.2 by PKA in cardiomyocytes and hippocampal neurons.
Microbubble contrast for radiological imaging: 1. Principles. (2006)

Microbubble contrast for ultrasound imaging in radiology has finally come of age, adding entirely new capabilities to real time imaging. Following a bolus injection into a peripheral vein of as little as 0.1mL of an aqueous suspension, contrast specific imaging modes show parenchymal and lesional perfusion in real time in the major organs of the abdomen and pelvis as well as breast, thyroid and prostate. These new imaging modes exploit the unique interaction between ultrasound and microbubbles, which gives rise to nonlinear echoes that are readily distinguishable from those of tissue. Furthermore, microbubbles can be deliberately disrupted by the ultrasound imaging field. The rate at which fresh bubbles then replenish the scanplane can be metered in subsequent images, offering a means to quantify both flowrate and relative vascular volume of the microvasculature in both organs and solid lesions.
Opposing Theories and the Buckling Strength of Unequal-Leg Angle Columns (2011)

A structural engineer wishing to determine the buckling load of unequal-leg angle columns receives conflicting information from published literature because researchers offer two radically different models for their analyses of thin-walled open-profile bars. One model considers the bar to be a continuum whereas the American Institute of Steel Construction adopts a noncontinuum multifilament model. Furthermore, the continuum model defines the normal planes of the deflected bar with the line of centroids whereas the multifilament model uses the shear center line. A test program based on 5×3×1/4 in. (127×76×6 mm) steel angles is proposed to resolve the issue by determining which model produces computed buckling loads that better correlate with collapse loads obtained from tests. The possibility that neither method produces a buckling load that correlates with collapse loads is not ruled out.
Fiber-Optic Chemical Sensors and Biosensors (2013–2015) (2015)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFiber-Optic Chemical Sensors and Biosensors (2013–2015)Xu-dong Wang*† and Otto S. Wolfbeis*‡View Author Information† Department of Chemistry, Fudan University, 200433 Shanghai, P. R. China‡ Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, D-93040 Regensburg, Germany*E-mail: [email protected]. Tel: +86 21 6564 2790.*E-mail: [email protected]. Fax: +49 941 943 4064. Tel: +49 941 943 4065.Cite this: Anal. Chem. 2016, 88, 1, 203–227Publication Date (Web):November 17, 2015Publication History Published online3 December 2015Published inissue 5 January 2016https://pubs.acs.org/doi/10.1021/acs.analchem.5b04298https://doi.org/10.1021/acs.analchem.5b04298review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views8395Altmetric-Citations352LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Coating materials,Fibers,Layers,Quantum mechanics,Sensors Get e-Alerts
Active damping of LCL-filter resonance based on virtual resistor for PWM rectifiers &#x2014; stability analysis with different filter parameters (2008)

This publication presents the investigation of active damping of resonance oscillations with virtual resistor for grid-connected PWM rectifiers with LCL-filter for different filter parameters. Using the voltage-oriented PI current control with converter current feedback, additional active damping of the filter resonance is necessary for stable operation. In the literature different methods are proposed that differ in number of sensors and complexity of control algorithms. If higher damping of the switching ripple current is required LCL-filters with lower resonance frequencies can be used. Resulting low ratios between resonance frequency and control frequency challenge the control with respect to damping of resonance. Moreover, some active damping methods are not suitable for these filter settings. Here the active damping concept based on virtual resistor is analyzed concerning stability for two significant filter configurations. It turns out that it is applicable for configurations with higher resonance frequency, whereas systems lower resonance frequencies can poorly be damped. Additionally the method exhibits the advantage of simple implementation but the disadvantage of additional current sensors. Theoretical analyses and of the selected method with time-discrete implementation are shown in this paper. Theory is verified by experimental results.
Multi-Scale Volume Model Building (2005)

P297 Multi-scale volume model building Introduction 1 E. MONSEN T. RANDEN L. SONNNELAND Schlumberger Stavanger Research P. O. Box 8013 N-4068 Stavanger Norway Taking on increasingly complex reservoirs and geometries that cannot practically be represented by bounding surfaces such as top and base horizons (e.g. carbonates channels salt...) necessitates a new generation of volume interpretation tools. The truly threedimensional nature of seismic data makes working in terms of volumes instead of primitive surfaces more attractive and convenient. Volume interpretation also provides better handling of geometries induced by volume properties that are not directly represented in a surface framework. An important
Oracle Certified Professional Application Developer Exam Guide (1999)

From the Publisher:
Certify your skills and demonstrate your expertise by earning your OCP credential - with help from this Oracle-authorized exam guide. The book provides full coverage of the Developer Track Release 2 exams as well as the Release 1 upgrade exams. Fully endorsed by Oracle Corporation and developed in conjunction with Oracle's OCP program, this book and CD-ROM package is a powerful preparation tool containing more than 400 practice exam questions.
EFFECT OF TREADMILL RUNNING ON CARDIAC AND SKELETAL MUSCLE METABOLISM AND RIGHT VENTRICLE INFLAMMATION IN RATS WITH PULMONARY ARTERIAL HYPERTENSION (2012)

MUSCLE METABOLISM AND RIGHT VENTRICLE INFLAMMATION IN RATS WITH PULMONARY ARTERIAL HYPERTENSION Tsungai J Chingombe1,2, Tim Lahm, Jag Reddy, Amanda Fisher, Irina Petrache, (Mary Beth Brown) Pulmonary and Critical Care, Department of Medicine, Indiana University School of Medicine, and Department of Physical Therapy, Indiana University School of Health and Rehabilitation Sciences, Indianapolis, Indiana
Measurements of Proton Energy Spectra Generated by Ultra Intense Laser Solid Interactions (2017)

In this study, we have presented proton energy spectra produced by such high irradiance ($\\mathrm{10^{20} \\ W/cm^{2}}$) lasers interacting with a pre formed plasma in front of the target and with solid targets without a pre formed plasma. The effects of the target thickness and the generated plasma on the maximum energy and proton numbers are assessed. It is observed that experimentally measured maximum proton energy and number of protons have a dependence on target thickness and preformed plasma scale length produced by prepulse laser with the irradiance of $\\sim 10^{12}$ W/$\\mathrm{cm^{2}}$. 2D EPOCH PIC code simulation results of the energy spectra of protons are in a good agreement with measured experimental results.
Enzymatic Synthesis of Estolides from Castor Oil (2020)

Estolides are fatty acid polyesters with applications in both industry and consumer products. Recently, reports have emerged detailing lipase-catalyzed synthesis of estolides from free hydroxy fatty acids. In this paper, we describe a simple alternative enzymatic process, in which castor oil is directly converted to an estolide mixture by Candida antarctica lipase A (CALA) catalyzed transesterification. The reaction mixture is analyzed by NMR to determine the estolide number (EN) and MALDI MS to identify individual components, in addition to titration to determine the acid value (AV). Estolide trimers and tetramers (EN 2–3) were formed over 24 h in a system with 2:1 (v/v) castor oil–water. Further, utilizing different lipase specificities, addition of Thermomyces lanuginosus lipase (TLL), allowed the CALA product mixture to be cleaned up by hydrolyzing attached glycerol. In addition, a three-enzyme process is suggested, in which a simple alcohol is added and Candida antarctica lipase B (CALB) is used to esterify carboxylic acids to lower AV.
Characterizing the operation of a large hydraulic excavator (2003)

This thesis studies the operation of a large hydraulic excavator (an O&K RH200) from data obtained by monitoring the machine during a regular operation period. The objective of the work is to build an understanding of how machine usage affects performance, extending across both productivity and maintenance issues. The results suggest that operator digging style is a significant factor in determining machine performance. Two dominant digging styles are identified, characterized by the trajectory of the bucket teeth. In the first style, the operator commands the bucket along the pit-floor, teeth pointing downward, the full face of the bucket exposed to the dig material. The net effect is a 'scooping' action on the material, forcing it into the bucket. This approach was found to result in higher bucket fills at the expense of higher machine duty. In the alternative style, the bucket enters higher in the muck-pile. After
 initial penetration, the bucket is rolled as it is lifted, so that rilling of the dig material assists the fill. This approach was found to yield lower fills but cause less damage. Four operators worked on the machine during the monitoring period. Their philosophy towards machine use was found to be linked to a digging technique. One operator set out to achieve high per-pass productivity and did so at the cost of high per-cycle damage. He used the first style almost exclusively. Two operators were sympathetic to the trade-off between performance and duty. They used the second style. They had lower per-pass productivity, but compensated for this by lower per-cycle damage. The fourth operator was a trainee. His inexperience manifested itself in low productivity, high variability, and high rates of machine damage. He favored the second style. These findings shed fight on machine operation and contribute towards the development of a
 performance and duty monitor for large hydraulic excavators.
Arbitrated quantum signature scheme based on reusable key (2014)

An arbitrated quantum signature scheme without using entangled states is proposed.In the scheme,by employing a classical hash function and random numbers,the secret keys of signer and receiver can be reused.It is shown that the proposed scheme is secure against several well-known attacks.Specifically,it can stand against the receiver’s disavowal attack.Moreover,compared with previous relevant arbitrated quantum signature schemes,the scheme proposed has the advantage of less transmission complexity.