gebhart/patrepeval huggingface dataset:
Morphology Control of Phase-Separation Texture by Elongation of Two-Liquids Immiscible Melt in Fe3O4-SiO2 System. (2000)

The existence of a liquid-liquid miscibility gap in Fe3O4-SiO2 system has been reported. In this study, phaseseparated glasses of 5Fe3O4⋅95SiO2 (mol%) were prepared by melting sintered rods of the same composition at 1800°C (in immiscible region) using an infrared imaging furnace and, subsequently, quenching with elongation of the melts at a constant rate. The glass quenched without elongation exhibited a binodal type phase separation texture consisting of discrete spherical Fe3O4-rich particles. On the contrary, in the sample quenched with elongation, Fe3O4-rich particles were stretched and oriented along the direction of elongation. The length of the stretched particles was proportional to the elongation distance and was not independent of the elongation rate within short elongation distance. However, the stretching of the particles was less pronounced for the long elongation ranges. This suggests that the spherical particles grown by phase separation in the binodal region, were stretched by viscous flow in the early stage of elongation and the stretching in the latter stage was reduced by restoration due to viscoelastic behavior and/or to a steep increase of viscosity. The deformation and orientation of phase separation texture could be achieved in this process, though this deformation proceeded under non-equilibrium conditions. Therefore, the operated elongation process of two-liquid immiscible melts may enable one to fabricate high-functional composite materials owing to morphology control of phase separation texture.
Liganded Thyroid Hormone Receptor-α Enhances Proliferation of Pancreatic β-Cells (2010)

Failure of the functional pancreatic beta-cell mass to expand in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing beta-cells is important for beta-cell proliferation in adult animals. In rat pancreatic beta-cell lines (RIN5F), treatment with 100 nM thyroid hormone (triiodothyronine, T(3)) enhances cell proliferation. This result suggests that T(3) is required for beta-cell proliferation or replication. To identify the role of thyroid hormone receptor alpha (TR(alpha)) in the processes of beta-cell growth and cell cycle regulation, we constructed a recombinant adenovirus vector, AdTR(alpha). Infection with AdTR(alpha) to RIN5F cells increased the expression of cyclin D1 mRNA and protein. Overexpression of the cyclin D1 protein in AdTR(alpha)-infected cells led to activation of the cyclin D1/cyclin-dependent kinase/retinoblastoma protein/E2F pathway, along with cell cycle progression and cell proliferation following treatment with 100 nM T(3). Conversely, lowering cellular cyclin D1 by small interfering RNA knockdown in AdTR(alpha)-infected cells led to down-regulation of the cyclin D1/CDK/Rb/E2F pathway and inhibited cell proliferation. Furthermore, in immunodeficient mice with streptozotocin-induced diabetes, intrapancreatic injection of AdTR(alpha) led to the restoration of islet function and to an increase in the beta-cell mass. These results support the hypothesis that liganded TR(alpha) plays a critical role in beta-cell replication and in expansion of the beta-cell mass during postnatal development. Thus, liganded TR(alpha) may be a target for therapeutic strategies that can induce the expansion and regeneration of beta-cells.
Binding of blood proteins to carbon nanotubes reduces cytotoxicity (2011)

With the potential wide uses of nanoparticles such as carbon nanotubes in biomedical applications, and the growing concerns of nanotoxicity of these engineered nanoparticles, the importance of nanoparticle-protein interactions cannot be stressed enough. In this study, we use both experimental and theoretical approaches, including atomic force microscope images, fluorescence spectroscopy, CD, SDS-PAGE, and molecular dynamics simulations, to investigate the interactions of single-wall carbon nanotubes (SWCNTs) with human serum proteins, and find a competitive binding of these proteins with different adsorption capacity and packing modes. The π-π stacking interactions between SWCNTs and aromatic residues (Trp, Phe, Tyr) are found to play a critical role in determining their adsorption capacity. Additional cellular cytotoxicity assays, with human acute monocytic leukemia cell line and human umbilical vein endothelial cells, reveal that the competitive bindings of blood proteins on the SWCNT surface can greatly alter their cellular interaction pathways and result in much reduced cytotoxicity for these protein-coated SWCNTs, according to their respective adsorption capacity. These findings have shed light toward the design of safe carbon nanotube nanomaterials by comprehensive preconsideration of their interactions with human serum proteins.
Serotoninergic stimulation of aldosterone secretion in the rat in vivo: role of the renin-angiotensin system (1991)

Serotoninergic control of aldosterone secretion in vivo was investigated in conscious rats with indwelling arterial cannulae. Serial blood samples were taken from the animals before and after i.p. administration of 1 ml (4 g/l) 5-hydroxytryptophan (5-HTP), the precursor of serotonin, or saline and they were analysed for 5-HTP, serotonin, 5-hydroxyindoleacetic acid, plasma renin activity (PRA), corticosterone, aldosterone, sodium and potassium concentrations. The role of the renin-angiotensin system was investigated in animals pretreated for 1 week with the angiotensin-converting enzyme inhibitor captopril (25 mg/day). 5-HTP caused a significant increase in all parameters within 45 min except for sodium and potassium. Saline administration showed no significant effect. Captopril pretreatment did not impair the increase in any parameter by 5-HTP, with the exception of the aldosterone response which was significantly attenuated, though not completely. The results show that administration of 5-HTP, which increases serum serotonin levels, stimulates PRA, aldosterone and corticosterone secretion. Captopril pretreatment inhibits the aldosterone response, suggesting that the aldosterone stimulatory properties of 5-HTP require the presence of angiotensin II, although it is unclear whether it acts in a mediatory or permissive capacity. The failure of captopril to inhibit the aldosterone response completely suggests the involvement of other mechanisms such as the hypothalamo-pituitary adrenal axis or a direct action of serotonin on the adrenal.
Figure S2 from A Somatostatin Receptor Subtype-3 (SST<sub>3</sub>) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors (2023)

&lt;p&gt;mRNA and protein expression pattern of key somatostatin receptors in non- functioning pituitary tumors (NFPTs) and normal pituitaries (NPs).&lt;/p&gt;
The potential for artificial intelligence in healthcare (2019)

The complexity and rise of data in healthcare means that artificial intelligence (AI) will increasingly be applied within the field. Several types of AI are already being employed by payers and providers of care, and life sciences companies. The key categories of applications involve diagnosis and treatment recommendations, patient engagement and adherence, and administrative activities. Although there are many instances in which AI can perform healthcare tasks as well or better than humans, implementation factors will prevent large-scale automation of healthcare professional jobs for a considerable period. Ethical issues in the application of AI to healthcare are also discussed.
A New Elastic Potential Function for Rubbery Materials (1973)

A new four-parameter elastic potential function is proposed which represents data on the elastic deformation of rubbery materials with the same parameters in various deformation fields up to break.
Fullerene recognition with molecular tweezers made up of efficient buckybowls: a dispersion-corrected DFT study (2015)

In 2007, Sygula and co-workers introduced a novel type of molecular tweezers with buckybowl pincers that have attracted the substantial interest of researchers due to their ideal architecture for recognizing fullerenes by concave-convex π∙∙∙π interactions (A. Sygula et al., J. Am. Chem. Soc., 2007, 129, 3842). Although in recent years some modifications have been performed on these original molecular tweezers to improve their ability for catching fullerenes, very few improvements were achieved to date. For that reason, in the present work a series of molecular tweezers have been devised and their supramolecular complexes with C60 studied at the B97-D2/TZVP//SCC-DFTB-D and B97-D2/TZVP levels. Three different strategies have been tested: (1) changing the corannulene pincers to other buckybowls, (2) replacing the tetrabenzocyclooctatetraene tether by a buckybowl, and (3) adding methyl groups on the molecular tweezers. According to the results, all the three approaches are effective, in such a way that a combination of the three strategies results in buckycatchers with complexation energies (with C60) up to 2.6 times larger than that of the original buckycatcher, reaching almost -100 kcal mol(-1). The B97-D2/TZVP//SCC-DFTB-D approach can be a rapid screening tool for testing new molecular tweezers. However, since this approach does not reproduce correctly the deformation energy and this energy represents an important contribution to the total complexation energy of complexes, subsequent higher-level re-optimization is compulsory to achieve reliable results (the full B97-D2/TZVP level is used herein). This re-optimization could be superfluous when quite rigid buckycatchers are studied.
Reconciling disparate information in continuity of care documents: Piloting a system to consolidate structured clinical documents (2017)

Abstract Background Due to the nature of information generation in health care, clinical documents contain duplicate and sometimes conflicting information. Recent implementation of Health Information Exchange (HIE) mechanisms in which clinical summary documents are exchanged among disparate health care organizations can proliferate duplicate and conflicting information. Materials and methods To reduce information overload, a system to automatically consolidate information across multiple clinical summary documents was developed for an HIE network. The system receives any number of Continuity of Care Documents (CCDs) and outputs a single, consolidated record. To test the system, a randomly sampled corpus of 522 CCDs representing 50 unique patients was extracted from a large HIE network. The automated methods were compared to manual consolidation of information for three key sections of the CCD: problems, allergies, and medications. Results Manual consolidation of 11,631 entries was completed in approximately 150 h. The same data were automatically consolidated in 3.3 min. The system successfully consolidated 99.1% of problems, 87.0% of allergies, and 91.7% of medications. Almost all of the inaccuracies were caused by issues involving the use of standardized terminologies within the documents to represent individual information entries. Conclusion This study represents a novel, tested tool for de-duplication and consolidation of CDA documents, which is a major step toward improving information access and the interoperability among information systems. While more work is necessary, automated systems like the one evaluated in this study will be necessary to meet the informatics needs of providers and health systems in the future.
The BH3-only protein Puma plays an essential role in cytokine deprivation–induced apoptosis of mast cells (2007)

Mast cells play critical roles in the regulation of inflammation. One characteristic feature of mast cells is their relatively long lifespan in vivo. Members of the Bcl-2 protein family are regulators of cell survival and apoptosis, where the BH3-only proteins are critical proapoptotic proteins. In this study we investigated the role of the BH3-only proteins Noxa, Bad, Bim, Bmf, Bid, and Puma in apoptosis of mucosal-like mast cells (MLMCs) and connective tissue-like mast cells (CTLMCs). We demonstrate that Puma is critical for the induction of mast-cell death following cytokine deprivation and treatment with the DNA-damaging agent etoposide in MLMCs and CTLMCs. Using p53-/- mast cells, we found that cytokine deprivation-induced apoptosis, in contrast to that elicited by etoposide, is p53-independent. Interestingly, mast cells deficient in FOXO3a, previously proposed as a transcription factor for Puma induction in response to growth factor deprivation, were markedly resistant to cytokine withdrawal compared with wild-type cells. Moreover, overexpression of phosphorylation-deficient, constitutively active FOXO3a caused an up-regulation of Puma. In conclusion, our data demonstrate a pivotal role for Puma in the regulation of cytokine deprivation-induced mast-cell apoptosis and suggest a plausible role for Puma in the regulation of mast cell numbers in vivo.
G. Baccrabère, Le sanctuaire rural antique d'Ancely, commune de Toulouse, (Supplément au Bulletin de Littérature Ecclésiastique), Institut Catholique de Toulouse, Chronique n° 1, Toulouse, 1988 (1989)

Matter Michel. G. Baccrabère, Le sanctuaire rural antique d'Ancely, commune de Toulouse, (Supplément au Bulletin de Littérature Ecclésiastique), Institut Catholique de Toulouse, Chronique n° 1, Toulouse, 1988. In: Revue d'histoire et de philosophie religieuses, 69e année n°3, Juillet-septembre 1989. pp. 337-339.
SlideSpace (2016)

The Slide and Canvas metaphors are two ways of helping people create visual aids for oral presentations. Although such physical metaphors help both authors and audiences make sense of material, they also constrain authoring in ways that can negatively impact presentation delivery. In this article, we derive heuristics for the design of presentation media that are independent of any underlying physical metaphors. We use these heuristics to craft a new kind of presentation medium called SlideSpace—one that combines hierarchical outlines, content collections, and design rules to automate the real-time, outline-driven synthesis of hybrid Slide-Canvas visuals. Through a qualitative study of SlideSpace use, we validate our heuristics and demonstrate that such a hybrid presentation medium can combine the advantages of existing systems while mitigating their drawbacks. Overall, we show how a heuristic design approach helped us challenge entrenched physical metaphors to create a fundamentally digital presentation medium with the potential to transform the activities of authoring, delivering, and viewing presentations.
Nonlinear performance of a PI controlled missile: an explanation (2002)

Considers the practical interest of an approach to nonlinear system analysis. Based on the incremental norm, this approach proposes performance and robustness analysis criteria. Using computationally efficient tests involving linear matrix inequality optimization, these criteria enable us to guarantee the performance and the robustness of a realistic PI controlled nonlinear missile.
F105 Investigation of porous flow field for Polymer Electrolyte Fuel Cell (2008)

High power density enhances polymer electrolyte fuel cell with widely varied applications. Our investigation focused on the refinement of the reactant gas flow field at the bipolar plate in order to increase the fuel cell performance. Applying a porous material to the reactant gas flow field is one possible method. Expected advantages of a porous flow field are an increase in reactant gas diffusivity and electron conductivity allover the electrode. An investigation was carried out to evaluate the feasibility of a porous flow field. The Lattice Boltzman simulation indicated that surface wettability and pore structure control have prospect of gas and water flow field separation. The experiment of porous flow field showed same level performance of channel type.
Angiogenesis and Cancer (2007)

Angiogenesis, the creation of neovasculatures from pre-existing ones, is required for various physiological processes. However, pathological angiogenesis is a hallmark of malignant tumors, metastasis and various ischemic as well as inflammatory disorders. Angiogenesis is regulated by the balance between proangiogenic factors and antiangiogenic factors, and concentrated effort in this area of research has led to the discovery of a growing number of angiogenesis-associated factors and the complex interactions among these factors. Understanding of the regulatory mechanisms of these factors in mediating the angiogenic process involved in tumor growth prompted the application of antiangiogenic factors on experimental tumor models with successful outcomes. Based on these experimental results, some antiangiogenic agents have been tested in clinical trials. In this review, the process and regulators of angiogenesis, the involvement of angiogenesis in cancer development and the application of antiangiogenic therapies on established tumors would be discussed. Among various antiangiogenic reagents, special emphasis will be given to antiangiogenic reagents derived from vascular basement membranes, a crucial regulator of angiogenesis, rather than a structural tissue component.
A proposed method for creating VCR functions using MPEG streams (2002)

The development of video-on-demand (VOD) systems for movie delivery requires that the user be able to perform VCR functions over a broadband network system. These functions include Play, Pause, Fast Forward, and Fast Rewind. No standard method exists between content developers, server manufacturers and client applications to provide these functions. This paper proposes a standard method for implementing these functions using MPEG streams and discusses some of the important tradeoffs. The encoding and distribution of content has become one of the most important issues facing video information providers. Today, in the case of movies, every service provider must encode the material for the specific equipment being deployed in the network. Therefore, the ease of use and speed of the algorithms employed to encode the material are extremely important. In the future, the creator of the content may encode the material once and distribute it to the service providers in compressed form, but this is not the case today due to the lack of standards.
Fate of Thymol and Its Monoglucosides in the Gastrointestinal Tract of Piglets (2020)

The monoterpene thymol has been proposed as a valuable alternative to in-feed antibiotics in animal production. However, the effectiveness of the antimicrobial is comprised by its fast absorption in the upper gastrointestinal tract. In this work, two glucoconjugates, thymol α-d-glucopyranoside (TαG) and thymol β-d-glucopyranoside (TβG), were compared with free thymol for their potential to deliver higher concentrations of the active compound to the distal small intestine of supplemented piglets. Additionally, an analytical method was developed and validated for the simultaneous quantification of thymol and its glucoconjugates in different matrices. In stomach contents of pigs fed with 3333 μmol kg<sup>-1</sup> thymol, TαG, or TβG, total thymol concentrations amounted to 3048, 2357, and 1820 μmol kg<sup>-1</sup> dry matter, respectively. In glucoconjugate-fed pigs, over 30% of this concentration was present in the unconjugated form, suggesting partial hydrolysis in the stomach. No quantifiable levels of thymol or glucoconjugates were detected in the small intestine or cecum for any treatment, indicating that conjugation with one glucose unit did not sufficiently protect thymol from early absorption.
A generalized sector bound approach to feedback stabilization of nonlinear control systems (2012)

This paper proposes and develops a generalized sector bound approach to feedback stabilization of nonlinear control systems described by state-space models. This approach is inherited from the methodology of the sector bounded or passive nonlinearities, and influenced by the concept of absolute stability. It aims not only to regionally stabilize the nonlinear dynamics asymptotically but also to maximize the estimated region of quadratic attraction and to ensure nominal performance at each equilibrium. Similar to gain scheduling control, a path of equilibria is programmed based on the assumption of centered-ϵ-cover which leads to a sequence of linear controllers that regionally stabilize the desired equilibrium asymptotically. Simulation results are worked out to illustrate our proposed design method.
Nicotinic Acetylcholine Receptors in Human Brain by the Constant Infusion Paradigm: Feasibility and Reproducibility (2005)

123I-5-IA-85380 (123I-5-IA; [123I]-5-iodo-3-[2(S)-azetidinylmethoxy]pyridine) is a promising SPECT radiotracer for imaging 2-containing nicotinic acetylcholine receptors (2-nAChRs) in brain. 2-nAChRs are the initial site of action of nicotine and are implicated in various neuropsychiatric disorders. The feasibility and reproducibility of the bolus-plus-constant-infusion paradigm for equilibrium modeling of 123I-5-IA using SPECT in healthy nonsmokers was studied. Methods: Ten healthy nonsmokers (mean age SD, 43.7 9.9 y) underwent two 123I-5-IA SPECT scans within 4 wk. 123 I-5-IA was administered as a bolus (125.8 14.6 MBq) plus constant infusion (18.1 1.5 MBq/h). SPECT acquisitions (30 min) and venous blood sampling were performed every 60 min throughout the infusion (10 –14 h). The test–retest variability and reliability of plasma activity (kBq/mL), the regional brain activity reflected by units of kBq/mL and %ID/mL (injected dose/mL brain tissue), and the equilibrium outcome measures VT (ratio of total uptake to total plasma parent concentration) and VT (ratio of total uptake to free plasma parent concentration) were evaluated in 4 brain areas, including thalamus, striatum, cortex, and cerebellum. Results: Linear regression analysis revealed that time–activity curves for both plasma and brain 123 I-5-IA activity stabilized by 5 h, with an average change of [2.5%/h between 6 an d8ho finfusion, permitting equilibrium modeling. The plasma free fraction (f1), total parent, and clearance demonstrated good test–retest variability (mean, 10.9%–12.5%), whereas the variability of free parent was greater (mean, 24.3%). Regional brain activity (kBq/ mL) demonstrated good test–retest variability (11.1%–16.4%) that improved when corrected for infusion rate (mean, 8.2%– 9.9%) or for injected dose (mean, 9.5%–13.3%). VT demonstrated better test–retest variability (mean, 7.0%– 8.9%) than VT (mean, 12.9%–14.6%). Reliability assessed by the intraclass correlation coefficient (ICC) was superior for kBq/mL (ICC 0.83– 0.90) and %ID/mL (ICC 0.93– 0.96) compared with VT (ICC 0.30 – 0.64) and VT (ICC 0.28 – 0.60). The lower reliability of VT was attributed to the poor reliability of the free fraction (ICC 0.35) and free parent (ICC 0.68). Conclusion: These results support the feasibility and reproducibility of equilibrium imaging with 123 I-5-IA for measurement of 2-nAChRs in
Translation of specific vaccinia virus RNAs purified as RNA-DNA hybrids on potassium iodide gradients (1979)

A procedure has been developed for purifying specific mRNAs by hybridization to fragments of DNA and isolation of the hybrids by potassium iodide equilibrium buoyant density centrifugation. The hybrids obtained are essentially free of unhybridized RNA as well as double-stranded RNA. Moreover, the RNA in the hybrids is undamaged and can be translated in vitro. Application of this procedure to mapping vaccinia virus genes is described. A total of 34 polypeptides have been assigned to three regions of the viral genome.
Experimental analysis of a matrix converter prototype based on new IGBT modules. (2005)

This paper describes the design and the solutions adopted for a matrix converter prototype of 10 kW based on new power modules manufactured by International Rectifier Corporation Italy. Experimental results are presented along with the comparison among different design possibilities.