gebhart/patrepeval huggingface dataset:
Usability Analysis of Messages from a Security System (1989)

Most software systems issue messages to reflect their progress in processing users' requests and to report error conditions. By instrumenting systems to collect these messages for later processing, a rich source of information about system and user behavior can be tapped. The work described herein is a study of system and user behavior related to messages, in an actual use setting. Our objective is assessing and improving the interaction with VMSECURE, a user directory management and security package for IBM's VM operating system. (VM is IBM's interactive system for mainframe computers. VMSECURE manages user resources and controls data access.) Pareto's principle applies to VMSECURE messages and error messages. A few different messages make up most of the traffic. Password prompting provides efficient, effective protection against unauthorized use of VMSECURE. Users of VMSECURE, when they receive an error messages, often re-enter the same, unsuccessful command again. Users of VMSECURE do not improve their error rates with experience, possibly due to the low level of daily use they make of the product.
Dionysus reborn: play and the aesthetic dimension in modern philosophical and scientific discourse (1990)

Mihai Spariosu here explores the significance of the closely linked concepts of play and aestheticism in philosophical and scientific discourse since the end of the eighteenth century. Spariosu points out that since its birth in archaic and classical Hellenic thought the concept of play has always been subject to the influences of various rational and prerational sets of values. Spariosu maintains that there have been not one but two major modern concepts of aestheticism: artistic aestheticism, related to a prerational mentality and introduced in modern thought by Schopenhauer and Nietzsche; and philosophicalscientific aestheticism, initiated by Kant and Schiller and shaped by rationalism. According to Spariosu, the first has often arisen in response to the attempts of philosophy and science to impose their standards on art, and the second has often been called on to deal with the epistemological crises that periodically shake these disciplines. Spariosu also looks closely at some of the play concepts that surface in modern science in connection with the Darwinian theory of evolution and the play of scientific discourse itself, as exemplified by the new physics and the contemporary philosophy of science. A penetrating and cogently argued book, Dionysus Reborn will be welcomed by readers interested in Continental philosophy, scientific discourse, and the aesthetics of play, including literary theorists, comparatists, philosophers, intellectual historians, and social scientists.
Software configuration management in an object oriented database (1995)

The task of configuration management for software development environments is not well supported by conventional files, directories, and ad hoc persistence mechanisms. Typed, immutable objects combined with ubiquitous versioning provide a much more sound basis. A prototype configuration management system currently under development relies upon persistent objects provided by a commercial object-oriented database system. Mechanisms and policies developed for this prototype simplify programming with persistent objects; results include simplicity of both design and implementation, as well as flexibility, and extensibility. Initial measurements suggest that performance is acceptable. 1 Introduction A practical software system consists of hundreds or thousands of separate but related components. A software development environment (SDE) must help manage this collection by providing configuration management services. Closely related is version management, often associated with tracking the ev...
Selective antegrade cerebral perfusion reduces brain injury following deep hypothermic circulatory arrest in the piglets' model by decreasing the levels of protein SUMO2/3-ylation. (2014)

Selective antegrade cerebral perfusion (SACP), which was adopted by many surgical groups for complex neonatal cardiac surgery, especially aortic arch repair, is a proven adjunct for neuroprotection during deep hypothermic circulatory arrest (DHCA). Several recent studies suggest that SUMO2/3 modification of proteins is markedly activated during deep hypothermia and believed to be an endogenous neuroprotective stress response. Here, we report that SACP reduces the increasing degree of SUMO2/3 conjugation following DHCA. Piglets were subjected to 1 h SACP and/or 1 h DHCA. DHCA was sufficient to markedly increase in protein SUMOylation by SUMO2/3 both in the hippocampus and cerebral cortex. SACP, especially at flow rate of 50 ml/kg/min, reduces the increasing degree of SUMO2/3 conjugation and also reduces levels of pro-apoptotic factors, Bax and Caspase 3, and increases levels of antiapoptotic factors, Bcl-2, following DHCA both in the hippocampus and cerebral cortex. This suggests that SACP at flow rate of 50 ml/kg/min is more appropriate for neuroprotection during DHCA in the pig model and level of protein SUMO2/3-ylation maybe an indicator of the degree of brain injury.
Thermal Management of GaN-on-Si High Electron Mobility Transistor by Copper Filled Micro-Trench Structure (2019)

Self-heating effect is a major limitation in achieving the full performance potential of high power GaN power devices. In this work, we reported a micro-trench structure fabricated on the silicon substrate of an AlGaN/GaN high electron mobility transistor (HEMT) via deep reactive ion etching, which was subsequently filled with high thermal conductive material, copper using the electroplating process. From the current-voltage characteristics, the saturation drain current was improved by approximately 17% with the copper filled micro-trench structure due to efficient heat dissipation. The I<sub>DS</sub> difference between the pulse and DC bias measurement was about 21% at high bias V<sub>DS</sub> due to the self-heating effect. In contrast, the difference was reduced to approximately 8% for the devices with the implementation of the proposed structure. Using Micro-Raman thermometry, we showed that temperature near the drain edge of the channel can be lowered by approximately ~22 °C in a HEMT operating at ~10.6 Wmm<sup>-1</sup> after the implementation of the trench structure. An effective method for the improvement of thermal management to enhance the performance of GaN-on-Silicon HEMTs was demonstrated.
[Non-extractible residues of aryl-14C-albendazole in sheep]. (1983)

The location of the intractable residues of 14C-ring labelled-albendazole has been investigated in the sheep. Numerous biochemical compounds have been isolated: pulmonary CO2, blood dextrose, glycogen, triglycerides, cholesterol, hemoglobin, plasmatic, cytosolic and microsomal proteins, nucleic acids . . . No incorporation into intermediary metabolisms has been put into evidence. On the contrary, a significant covalently bound radioactivity has been observed on hepatic and plasmatic proteins. No covalent binding to hepatic DNA seems to be produced.
Non-Contact Impedance Imager with Phase Differentiator (2006)

This paper proposes a new non-contact impedance imager based on phase differential technique enabling an enhanced detection of the existence of a tumor in tissues. The developed sensor is composed of an air supply system and two optical fiber based distance sensors next to the air nozzle. For a periodic air pressure, two distance sensors provide us with sinusoidal outputs with individual phases. The phase difference varies according to the change of impedance parameters of tissues between two points. A big advantage of the sensor is that the sensor can work irrespective of the color of tissues. Toward the implementation into human lung, the impedance parameters are measured for lung in vitro by using the developed sensor
Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration (1995)

Numerous studies, both in vitro and in vivo, have demonstrated the insulin-mimetic properties of vanadium. Chronic oral administration of inorganic and organic compounds of both vanadium(IV) and vanadium(V) reduced plasma glucose levels and restored plasma lipid levels in streptozotocin-diabetic rats. We investigated the acute effects of both vanadyl sulfate and bis(maltolato)oxovanadium(IV) (BMOV), an organic vanadium compound, on plasma glucose levels by several routes of administration. Previous studies have shown that chronic administration of vanadyl sulfate has resulted in a sustained euglycemia following withdrawal of the drug. This effect was not observed following the chronic administration of BMOV; therefore, we investigated the effect of increasing the concentration of BMOV on the production of a sustained euglycemic response. An acute plasma glucose lowering effect was obtained with both vanadyl sulfate and BMOV when administered as a single dose by either oral gavage or intraperitoneal injection. In those animals that responded to vanadium treatment, plasma glucose levels were within the normal range within 2 to 6 h when given by i.p. injection or within 4 to 8 h when given by oral gavage. BMOV-treated rats that responded to treatment maintained the euglycemic effect for extended periods, ranging from 1 to 14 weeks following administration. However, vanadyl sulfate treated rats reverted to hyperglycemia within 12 to 24 h, depending on the route of administration. Intravenous administration of BMOV was effective in lowering plasma glucose levels only when administered by continuous infusion. An oral dose-response curve showed that BMOV was 2 to 3 times as potent as vanadyl sulfate. This difference in potency was observed with both oral and intraperitoneal administration, which suggests that the increase in potency with BMOV cannot be totally attributed to increased gastrointestinal absorption. Organic chelation of vanadium may facilitate uptake into vanadium-sensitive tissues. Chronic oral administration of higher concentrations of BMOV did not result in a sustained reduction in plasma glucose following withdrawal of the drug. All diabetic rats eventually responded to increased concentrations of BMOV with a restoration of plasma glucose levels to normal values; however, reversion to the hyperglycemic state occurred within 2 days of withdrawal of treatment. Chronic oral administration of BMOV did not produce a sustained euglycemic effect following withdrawal, but acute administration of the compound by either oral gavage or intraperitoneal injection did produce a long-term reduction in plasma glucose levels. Rats treated chronically with vanadyl sulfate remained euglycemic even after the drug was withdrawn. However, acute treatment produced only a transient euglycemia.
Multiple Probe Nearfield Scanning for EMC-Investigations (1997)

Antennas such as log-periodic arrays are often used to quantify the emission of electromagnetic radiation from a test object. The calibration of such relatively large antennas is a challenging task with conventional farfield measuring sites, while nearfield scanning offer an advantageous alternative. From basic electromagnetic theory it is well-known that correct farfield data from a nearfield to farfield transformation can only be obtained if the nearfield is measured on a closed surface around the antenna under test. The consequence of sequentially scanning on a closed envelope is that measurement time becomes considerable, which cannot be accepted if these involve test persons. To overcome these drawbacks, a new multiple probe scanning technique is proposed.
Geminivirus Vectors for Transient Gene Silencing in Plants (2004)

Both RNA and DNA viruses have been engineered to serve as vectors for transient silencing in intact plants. Host gene sequences carried by the virus are seen by the plant as "foreign," and homologous gene-silencing machinery acts on both the viral vector RNA and the endogenous host gene mRNA. DNA viruses, such as geminiviruses, are advantageous for silencing because only their mRNAs are silenced and their DNA genomes continue to replicate and move. The conserved genome organization of geminiviruses and the fact that they can be cloned into Escherichia coli plasmids, propagated, and then inoculated into plants for infection simplifies the procedure for silencing specific chromosomal genes in intact plants. This chapter describes the development of a silencing vector from cabbage leaf curl virus for use in Arabidopsis and procedures for silencing two genes simultaneously.
Agave: A benchmark suite for exploring the complexities of the Android software stack (2016)

Traditional suites used for benchmarking high-performance computing platforms or for architectural design space exploration use much simpler virtual memory layouts and multitasking/ multithreading schemes, which means that they cannot be used to study the complex interactions among the layers of the Android software stack. To demonstrate this, we present memory reference and concurrency data showing how Android applications differ from traditional C benchmarks. We propose the Agave suite of open-source applications as the basis for a standard, multipurpose Android benchmark suite. We make all sources and tools available in hopes that the community will adopt and build on this initial version of Agave.
MR Elastography Sequence Comparison: Standard PC MRE vs. Balanced Alternating Steady-State Elastography (2006)

S. Maderwald, F. Stock, O. Kraff, A. de Greiff, O. Bieri, K. Scheffler, M. E. Ladd Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, MR Physics, Demartment of Medical Radiology, University of Basel, Basel, Switzerland Introduction MR elastography (MRE) has been shown to be capable of non-invasively measuring tissue elasticity even in deep-lying regions. The feasibility of performing these measurements in skeletal muscle has already been established (1). The present study makes a phantom and an in vivo comparison between a standard MRE phase-contrast (PC) sequence and a balanced SSFP based sequence called Balanced Alternating Steady-State Elastography (BASEL) (2). A cylindrical agarose phantom (1%; 18cm height and 12 cm diameter) with a stiffer cylindrical inclusion (2%, diameter 2cm) and the biceps brachii in a group of 8 healthy volunteers in the age range of 27-38 years were examined. Methods All measurements were performed on a 1.5 Tesla scanner (Sonata, Siemens Medical Solutions, Erlangen, Germany) equipped with a gradient system capable of 40 mT/m maximum amplitude and a slew rate of 200 mT/m/ms. The mechanical waves were induced into the region of interest with a piezoelectric oscillator (3). To visualize the mechanical waves in the phantom and the biceps tissue, a gradient echo PC MRE sequence and a BASEL sequence synchronized to the oscillation were used. The shear modulus was determined from the wavelength inside the tissue using eight equidistant phase offsets and motion encoding in the spatial direction parallel to the mechanical excitation. The oscillator was coupled to the region of interest via a Plexiglas rod. Properties of the mechanical wave were: a frequency of 200 or 147 Hz and an amplitude of 200 μm or 600 μm in the left to right direction for phantom and in vivo measurements, respectively. Transverse slices through the phantom and coronal slices along the muscle were acquired for both sequence types. Parameters: TR= 60 / 7.5 ms (84 / 10.48 ms), TE = 18.6 / 3.75 ms (24.9 / 5.24 ms), FOV 200 mm (100 mm), BW 260 / 888 Hz/pixel, 1 slice, matrix 256 x 256, slice thickness 5 mm resulting in a TA of 123 / 31 s (172 / 43 s) for all eight phase offsets for PC / BASEL in the phantom (in vivo). Special parameters of the PC sequence: 3 trapezoidal motion sensitizing gradients with 10 mT/m (20 mT/m) amplitude; the motion sensitivity of BASEL is derived from the inherent readout gradient. For comparison, the phase images were compared regarding equivalency (wave peak and trough appearance). Additionally, the LFE technique (4) was used to determine shear wave speed and to estimate the shear modulus of the phantom/muscle. The shear modulus for each sequence was taken as the average reconstructed elasticity in identical ROIs placed in 1) the background of the phantom, 2) the inclusion of the phantom, and 3) the muscle belly.
Group velocity control by cascaded χ(2) interactions (2005)

We experimentally demonstrate that the group velocity of ultrashort pulses can be controlled through χ(2)-cascaded interactions. This is achieved by propagating 35fs pulses around 1400nm in a 25-mm-long periodically poled stoichiometric lithium tantalate crystal.
Differences in Catalytic Sites for CO Oxidation and Propylene Epoxidation on Au Nanoparticles (2011)

Sintering and increased Au loading of Au/TS-1 causes the rate of CO oxidation per mole of Au to increase, whereas that for epoxidation of propylene in O2 and H2 decreases. This opposite trend in rate behavior shows that the catalytic sites for the two reactions must be different.
Extended microtunnels in GaN prepared by wet chemical etch (2006)

It is demonstrated in GaN that microtunnels extended beyond hundreds of microns can be easily achieved using wet chemical etch. To obtain this result, specially designed structures of GaN layers are first grown on sapphire substrates with metal-organic chemical vapor deposition and subsequently with hydride vapor phase epitaxy techniques. The prepared samples are then chemically etched in molten KOH. With the designed structure of GaN layers, extended microtunnels with triangular cross sections are formed. The crystallographic planes of the triangular bevels belong to the {112¯2} family. The etch rate of the tunnel can be as high as 10μm∕min at proper etching conditions.
Wide bandwidth thin film BAW filters (2005)

Wide bandwidth filters are of interest in current and emerging wireless and system applications for use in IF circuits or as front end filters. Filters for the new GPS M code and for wireless LAN are required to have bandwidths approaching 4% of center frequency. The paper describes design and fabrication methods for obtaining wide bandwidth filters for GPS and wireless LAN applications using coupled resonator filters. Experimental results are presented.
SDrA's Take on Specialisation (2010)

The recognition of sports medicine as a medical specialty is examined from the perspective of Sports Doctors Australia (SDrA). The author commends the Australian Government's decision to recognise the significant role of sports medicine in health promotion, the prevention of illness and management of activity related injuries and illnesses.
Global Epigenetic Analysis Reveals H3K27 Methylation as a Mediator of Double Strand Break Repair (2021)

Abstract The majority of cancer patients is treated with ionizing radiation (IR), a relatively safe and effective treatment considered to target tumors by inducing DNA double strand breaks (DSBs). Despite clinical interest in increasing the efficacy of IR by preventing successful DSB repair, few effective radio-adjuvant therapies exist. Extensive literature suggests that chromatin modifiers play a role in the DSB repair and thus may represent a novel class of radiosensitizers. Indeed, chromatin has both local and global impacts on DSB formation, recognition of breaks, checkpoint signaling, recruitment of repair factors, and timely DSB resolution, suggesting that epigenetic deregulation in cancer may impact the efficacy of radiotherapy. Here, using tandem mass spectrometry proteomics to analyze global patterns of histone modification in MCF7 breast cancer cells following IR exposure, we find significant and long-lasting changes to the epigenome. Our results confirm that H3K27 trimethylation (H3K27me3), best known for mediating gene repression and regulating cell fate, increases after IR. H3K27me3 changes rapidly, accumulating at sites of DNA damage. Inhibitors of the Polycomb related complex subunit and H3K27 methyltransferase EZH2 confirm that H3K27me3 is necessary for DNA damage recognition and cell survival after IR. These studies provide an argument for evaluating EZH2 as a radiosensitization target and H3K27me3 as a marker for radiation response in cancer. Proteomic data are available via ProteomeXchange with identifier PXD019388.
Multi-locus and long amplicon sequencing approach to study microbial diversity at species level using the MinION™ portable nanopore sequencer (2017)

The miniaturized and portable DNA sequencer MinION™ has demonstrated great potential in different analyses such as genome-wide sequencing, pathogen outbreak detection and surveillance, human genome variability, and microbial diversity. In this study, we tested the ability of the MinION™ platform to perform long amplicon sequencing in order to design new approaches to study microbial diversity using a multi-locus approach. After compiling a robust database by parsing and extracting the rrn bacterial region from more than 67000 complete or draft bacterial genomes, we demonstrated that the data obtained during sequencing of the long amplicon in the MinION™ device using R9 and R9.4 chemistries were sufficient to study 2 mock microbial communities in a multiplex manner and to almost completely reconstruct the microbial diversity contained in the HM782D and D6305 mock communities. Although nanopore-based sequencing produces reads with lower per-base accuracy compared with other platforms, we presented a novel approach consisting of multi-locus and long amplicon sequencing using the MinION™ MkIb DNA sequencer and R9 and R9.4 chemistries that help to overcome the main disadvantage of this portable sequencing platform. Furthermore, the nanopore sequencing library, constructed with the last releases of pore chemistry (R9.4) and sequencing kit (SQK-LSK108), permitted the retrieval of the higher level of 1D read accuracy sufficient to characterize the microbial species present in each mock community analysed. Improvements in nanopore chemistry, such as minimizing base-calling errors and new library protocols able to produce rapid 1D libraries, will provide more reliable information in the near future. Such data will be useful for more comprehensive and faster specific detection of microbial species and strains in complex ecosystems.
Decoupling the Characteristics of Magnetic Nanoparticles for Ultrahigh Sensitivity (2022)

Immunoassays exploiting magnetization dynamics of magnetic nanoparticles are highly promising for mix-and-measure, quantitative, and point-of-care diagnostics. However, how single-core magnetic nanoparticles can be employed to reduce particle concentration and concomitantly maximize assay sensitivity is not fully understood. Here, we design monodisperse Néel and Brownian relaxing magnetic nanocubes (MNCs) of different sizes and compositions. We provide insights into how to decouple physical properties of these MNCs to achieve ultrahigh sensitivity. We find that tricomponent-based Zn<sub>0.06</sub>Co<sub>0.80</sub>Fe<sub>2.14</sub>O<sub>4</sub> particles, with out-of-phase to initial magnetic susceptibility χ″/χ<sub>0</sub> ratio of 0.47 out of 0.50 for magnetically blocked ideal particles, show the ultrahigh magnetic sensitivity by providing a rich magnetic particle spectroscopy (MPS) harmonics spectrum despite bearing lower saturation magnetization than dicomponent Zn<sub>0.1</sub>Fe<sub>2.9</sub>O<sub>4</sub> having high saturation magnetization. The Zn<sub>0.06</sub>Co<sub>0.80</sub>Fe<sub>2.14</sub>O<sub>4</sub> MNCs, coated with catechol-based poly(ethylene glycol) ligands, measured by our benchtop MPS show 3 orders of magnitude better particle LOD than that of commercial nanoparticles of comparable size.