gebhart/patrepeval huggingface dataset:
[Dirt tattooing following an explosion in a chemistry class]. (1984)

Traumatic tattooing following an explosion can generally be removed by rubbing with a hard-bristle handbrush within 48 h after the accident occurs. This measure failed, however, in the case of a pupil with extensively dispersed granular material in the face. The patient had mixed approximately 5 g of potassium permanganate and red phosphorus together during a chemistry lesson (!), thereby causing an explosion. A conservative treatment of applying compresses moistened with a sodium bicarbonate solution led to healing without scars.
Use of β,γ‐Unsaturated α‐Ketocarbonyls for a Totally Regioselective Oxidative Multicomponent Synthesis of Polyfunctionalized Pyridines (2009)

International audience
Value of renography following radical pelvic cancer surgery (1972)

Abstract Several cases are presented to illustrate how the radioisotope renogram has become an important adjunct in the postoperative evaluation of cancer patients requiring ileal conduit urinary diversion. The use of the renogram in the immediate postoperative period is best exemplified by its ability to aid in differentiating between the causes of oliguria. The sensitivity of the renogram in detecting urinary tract obstruction makes it particularly valuable in the long term management of these patients, whose urinary tract is in constant jeopardy, since it is safer and more convenient than commonly employed radiographic procedures.
Compiling Python to a hybrid execution environment (2010)

A new compilation framework enables the execution of numerical-intensive applications, written in Python, on a hybrid execution environment formed by a CPU and a GPU. This compiler automatically computes the set of memory locations that need to be transferred to the GPU, and produces the correct mapping between the CPU and the GPU address spaces. Thus, the programming model implements a virtual shared address space. This framework is implemented as a combination of unPython, an ahead-of-time compiler from Python/NumPy to the C programming language, and jit4GPU, a just-in-time compiler from C to the AMD CAL interface. Experimental evaluation demonstrates that for some benchmarks the generated GPU code is 50 times faster than generated OpenMP code. The GPU performance also compares favorably with optimized CPU BLAS code for single-precision computations in most cases.
The Genitalia and Wing Venation of the Cucujidæ and Related Families* (1930)

The family Cucujidæ has attracted considerable interest because of the remarkable structural differences found in some of the genera. This diversity of structure indicates that the family is a very old one which has lost many of the intermediate forms. Sharp and Muir ('12) found that the male genitalia of the Cucujidæ are also very variable and for this reason they give the family a central position in the series Cucujoidea. A number of families are then derived from the Cucujidæ, including the Coccinellidæ and Endomychidæ. In some cases the connecting links between the families are rather obscure. A study of the morphology of the Coccinellidæ begun at North Carolina State College convinced me that a further study of the genitalia of the Cucujidæ and the related families would probably clarify the relationship of these families.
Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well‐Tolerated (2016)

The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.
Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion (2016)

Polymerization of the cytosolic protein actin is critical to cell movement and host cell invasion by the malaria parasite, Plasmodium falciparum. Any disruption to actin polymerization dynamics will render the parasite incapable of invading a host cell and thereby unable to cause infection. Here, we explore the potential of using truncated latrunculins as potential chemotherapeutics for the treatment of malaria. Exploration of the binding interactions of the natural actin inhibitor latrunculins with actin revealed how a truncated core of the inhibitor could retain its key interaction features with actin. This truncated core was synthesized and subjected to preliminary structure-activity relationship studies to generate a focused set of analogues. Biochemical analyses of these analogues demonstrate their 6-fold increased activity compared with that of latrunculin B against P. falciparum and a 16-fold improved selectivity ex vivo. These data establish the latrunculin core as a potential focus for future structure-based drug design of chemotherapeutics against malaria.
The Politics of Innovation (1998)

This essay provides a historical perspective on the process of innovation in American communications. It is drawn from a larger, ongoing study of communications policy in the post-office department, Western Union, and the Bell System in the formative era that stretched from the adoption of the Constitution to World War I. This period holds special interest for students of innovation, since it witnessed the establishment of a modern postal system as well as the commercialization of the electric telegraph and telephone—three of the most notable improvements in communications technology during the past two hundred years.
Evaluation of the antibacterial activity and toxicity of Terminalia ferdinandia fruit extracts (2011)

Introduction: Terminalia ferdinandiana is an endemic Australian native plant with a history of use as a food and as a medicinal agent by indigenous Australians. Yet the medicinal bioactivities of this plant are poorly studied. In the current study, solvent extracts from T. ferdinandiana fruit pulp were tested for antimicrobial activity and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 13 of the 14 bacteria tested (92.9%). The deionised water extract inhibited the growth of 11 of the 14 bacteria tested (78.6%). The ethyl acetate, chloroform and hexane extracts inhibited 21.4%, 28.6% and 14.3% respectively. T. ferdinandiana methanolic extracts were approximately equally effective against Grampositive (100%) and Gram-negative bacteria (90%). All other extracts were more effective at inhibiting the growth of Gram-positive bacteria. The water, ethyl acetate, chloroform and hexane extracts inhibited the growth of 100, 50, 50 and 50% Gram-positive bacteria respectively. In contrast, they inhibited the growth of 70, 10, 20 and 0% Gram-negative respectively. All T. ferdinandiana extracts were either non-toxic (ethyl acetate, chloroform, hexane) with no significant increase in mortality induction, or of low toxicity (LC50 &gt;1000 姯ml) (methanol, deionised water) in the Artemia fransiscana bioassay. Conclusions: The low toxicity of the T. ferdinandiana extracts and their inhibitory bioactivity against bacteria validate Australian Aboriginal usage of T. ferdinandiana and indicates its medicinal potential as well as its potential as a source of natural ascorbic acid.
Estimating Time from Atomic Clocks (1983)

A Kalman recursive algorithm for estimating time from an ensemble of atomic clocks has been developed. The algorithm allows for the addition or deletion of clocks at any time, and provides automatic error detection and correction. The observations consist of time differences between clocks and may be taken at unequally spaced time points. Maximum likelihood estimates of the unknown parameters are obtained with confidence intervals, as well as hypothesis tests to determine whether the estimated parameters are significantly different from zero. The program is operational on the National Bureau of Standards' Time and Frequency Division's PDP 11/70.
Abstract B26: Design and synthesis of furoquinoline derivatives as potential drug candidates for the treatment of lung cancers. (2014)

Abstract Quinoline moiety is present in many classes of biologically active compounds. Recently, we have synthesized certain quinolone, 2-phenylquinoline, 2-furanylquinoline, and 4-anilinofuro[2,3-b]quinoline derivatives for biological evaluations. Among them, 1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone (CIL-102) was the most potent with a mean GI50 value of 0.025 μM against the growth of nine types of cancer cells and therefore, was further evaluated on its effects of cell cycle distribution. Results indicated CIL-102 induces cell cycle arrest in G2/M followed by apoptosis. CIL-102 bounds to tubulin at a single site with a dissociation constant of 0.4 μM. An analysis of the modified Dixon plot suggested that CIL-102 competitively inhibited the binding of podophyllotoxin, a colchicine-binding site agent, to tubulin. However, some drawbacks such as lack of selective cytotoxicity, poor oral bioavailability, and poor water solubility exhibited by CIL-102 prompted us to search for newer derivatives. Through extensive structural optimization, the new lead compound named as CYW-1865 which possesses aminoalkoxyimino side chain, exhibited selective anticancer activity, higher oral bioavailability, and higher water solubility than that of CIL-102. Xenographic studies indicated the tumor size with CYW-1865 treated nude mice was significantly lower than control. Further evaluation in an orthotopic lung cancer model indicated that CYW-1865 can be absorbed readily through oral administration, distributed to lung tissue, and exhibited significant efficacy in inhibiting the growth of lung cancers. Strategies for design and synthesis of CYW-1865 and its further structural optimization will be presented. Citation Format: Cherng-Chyi Tzeng, Chih-Hua Tseng, Yeh-Long Chen. Design and synthesis of furoquinoline derivatives as potential drug candidates for the treatment of lung cancers. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr B26.
Contact-Activated Factors: Contaminants of Immunoglobulin Preparations with Vasoactive and Coagulant Properties (1979)

Immune globulins (IG) may cause adverse vasoactive reactions. Twenty-four IG solutions (16.5% protein) made by 5 manufacturers were analyzed for components of the contact-activation system, which could mediate such reactions. Kallikrein (K) was measured with S-2302 as the substrate and prekallikrein activator (PKA), by its activation of prekallikrein to K with [3H]TAME, BAEE, or S-2302 as the substrate. Capillary permeability (CP) was determined by intradermal injection of IG into guinea pigs pretreated with Evans Blue dye. The K activity in the 24 lots ranged from &lt;0.01 to 0.67 TAME U/ml. PKA activity varied from 5 to 5000% that of a reference preparation (Plasma Protein Fraction) that had caused PKA-associated hypotension in recipients. Lots exhibiting medium to high K and/or PKA activity caused increased CP. All lots tested shortened the non-activated partial thromboplastin time (PTT) of normal plasma. Two lots that corrected the activated PIT of XI-deficient plasma and reacted with anti-XI antibody by immunodiffusion were gel chromatographed. Coagulant activity was co-eluted with IgG (i.e., M r ~ that of XIa); only those fractions containing K or PKA caused increased CP. Thus, XIa is responsible for coagulant activity in some IG preparations, whereas PKA and K may be present in sufficient quantities to cause vasoactive reactions.
Self‐Assembled, Millimeter‐Sized TIPS‐Pentacene Spherulites Grown on Partially Crosslinked Polymer Gate Dielectric (2015)

Here, a highly crystalline and self‐assembled 6,13‐bis(triisopropylsilylethynyl) pentacene (TIPS‐Pentacene) thin films formed by simple spin‐coating for the fabrication of high‐performance solution‐processed organic field‐effect transistors (OFETs) are reported. Rather than using semiconducting organic small‐molecule–insulating polymer blends for an active layer of an organic transistor, TIPS‐Pentacene organic semiconductor is separately self‐assembled on partially crosslinked poly‐4‐vinylphenol:poly(melamine‐ co ‐formaldehyde) (PVP:PMF) gate dielectric, which results in a vertically segregated semiconductor‐dielectric film with millimeter‐sized spherulite‐crystalline morphology of TIPS‐Pentacene. The structural and electrical properties of TIPS‐Pentacene/PVP:PMF films have been studied using a combination of polarized optical microscopy, atomic force microscopy, 2D‐grazing incidence wide‐angle X‐ray scattering, and secondary ion mass spectrometry. It is finally demonstrated a high‐performance OFETs with a maximum hole mobility of 3.40 cm 2 V −1 s −1 which is, to the best of our knowledge, one of the highest mobility values for TIPS‐Pentacene OFETs fabricated using a conventional solution process. It is expected that this new deposition method would be applicable to other small molecular semiconductor–curable polymer gate dielectric systems for high‐performance organic electronic applications.
The Austrian System of Social Housing Finance (2005)

&quot;In the international discussion on housing finance plenty of contributions are given on the system of mortgage backed securities (MBS), as practiced in USA, about the contract saving scheme (&quot;&quot;Bausparkassen&quot;&quot;), as a basic housing financing model in Central Europe, little about alternative models as the Canadian mortgage insurance scheme or the Danish Mortgage Bank. But rarely any discussion is taking place on the widely unique Austrian model of housing finance, despite the fairly persuasive results, as shown below. In the paper in hand the author tries to give a brief overlook to the Austrian system of social housing finance in all its aspects. Therefore it is necessary to touch as different fields as law, finance and political economy. The complexity of the model, as a result of an ongoing process of improvement, is one of the reasons of its success. But of course it is as well a reason of the difficulty to bring the model to international discussion. &quot;
Contrast Thresholds of the Human Eye (1946)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Richard Blackwell, "Contrast Thresholds of the Human Eye," J. Opt. Soc. Am. 36, 624-643 (1946) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Assessing Technological Competencies (2006)

AbstractThe following sections are included:General IntroductionTechnical IntroductionCompany identification and reassignmentsTechnology categorisationsIdentifying important patentsResearch BackgroundScience citation analysisBasics of patent citation analysisEconomic and policy analysisIndicator DefinitionsNumber of patentsCompany name unificationCompany restatementReassignmentsRestatement limitationChoice of companiesPatent growth percentage and percentage of company patents according to areaCites per patentCurrent impact index (CII)Technology strength (TS)Technology cycle timeScience linkageScience strengthConclusions
CHARACTERIZATION AND CRYOPRESERVATION OF SEMEN FROM ENDANGERED MARKHOR GOATS (CAPRA FALCONERI HEPTNERI) WITH EVALUATION OF REPRODUCTIVE SEASONALITY (2013)

The aims of this study were to determine the reproductive seasonality of four captive markhor goats (Capra falconeri heptneri), to characterize semen collected by electroejaculation, and to compare extenders and processing techniques for semen cryopreservation. Over the course of 1 yr, mean monthly scrotal circumference, serum testosterone, and fecal testosterone were measured and found to be inversely associated with day length. Maximum scrotal circumference (25.2 +/- 0.9 cm), serum testosterone (521.0 +/- 103.4 ng/dl), and fecal testosterone (382.5 +/- 90.3 ng/g) occurred in November, when day length was short (9.7 +/- 0.1 hr). Once a month for 3 mo (December, January, and February), bucks were anesthetized for electroejaculation and semen evaluation. Semen samples were divided into six aliquots for extension and cryopreservation in soy-based Bioxcell or Tris-based extender with 5 or 15% egg yolk, with and without centrifugation. Samples were then thawed for repeat evaluation 1-3 mo later. Postthaw evaluation revealed no significant differences between centrifuged and noncentrifuged samples. Sperm in Tris 5% and 15% egg yolk displayed higher total motility at 0, 3, and 6 hr postthaw and higher progressive motility postthaw compared with sperm in Bioxcell (P < 0.05). Sperm in Bioxcell displayed higher viability than sperm in both Tris-egg yolk extenders (P < 0.01), more intact acrosomes than sperm in Tris-15% egg yolk (P < 0.05), and a tendency for more intact acrosomes than sperm in Tris-5% egg yolk (P < 0.10). Sperm in Tris-5% egg yolk tended to have a higher percentage of morphologically normal sperm compared with Bioxcell (P < 0.10). This study provides evidence that markhor goats exhibit seasonality in scrotal circumference and testosterone levels and that centrifugation may be eliminated from the processing of markhor semen.
Effects of Mercuric Chloride on Growth and Morphology of Selected Strains of Mercury-Resistant Bacteria (1975)

A survey of the comparative cytological effects of growth in the presence of mercury by a group of mercury-resistant bacterial cultures and a characterization of the process of bacterial adaptation to Hg2+ ion was accomplished. Mercury resistance was found to be dependent upon the ability to volatilize mercury from the medium and upon the amount of mercury accumulated by the cells. The results indicate that most cultures which adapt to growth in the presence of HgCl2 exhibit extensive morphological abnormalities. Significant effects are delay in the onset of growth and cell division and numerous structural irregularities associated with cell wall and cytoplasmic membrane synthesis and function. A detailed analysis of the adaptation process and the resulting effects on morphology was performed on an Enterobacter sp. During the period preceding active multiplication, a selection for mercury-resistant mutants occurred. It was also demonstrated that growth commenced only at a specific threshold concentration of HG2+.
A Simple and Robust Vector-Based shRNA Expression System Used for RNA Interference (2013)

This novel design describes an inexpensive and effective way to clone and express single or multiple shRNAs from the same vector with the capacity for potent and effective silencing of target genes.
Sequential Pattern Mining Algorithm Based on Map Reduce (2012)

Traditional data mining algorithm has computing power shortage in dealing with mass data set.Aiming at the problem,a distributed sequential pattern mining algorithm based on Map Reduce programming model named MR PrefixSpan is proposed.Mining tasks are decomposed to many,the Map function is used to mine each Prefix projected sequential pattern,and the projected databases are constructed parallelly.It simplifies the search space and acquires a higher mining efficiency.Then the intermediate values are passed to a Reduce function which merges together all these values to produce a possibly smaller set of values.Experimental results on Hadoop cluster show that MR PrefixSpan can reduce the time of scanning data base,has higher parallel speed up ratio and better expansibility.
Coumarins from Cnidium monnieri and their Antiosteoporotic Activity (2007)

Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i. e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson. Among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoclasts derived from rat marrow cells.
CARACTERIZACIÓN CLÍNICO-PATOLÓGICA DEL SÍNDROME DE POLIPOSIS SERRADA (2013)

Introducción: el síndrome de poliposis serrada (SPS) se asocia a una probabilidad aumentada de desarrollar càncer colorrectal (CCR). Sus características clínico-patológicas y el riesgo de CCR en los individuos y sus familiares no están bien establecidas. Objetivo: describir las características clínico-patológicas del SPS en una serie amplia de pacientes. Material y Método: anàlisis retrospectivo de una cohorte de 67 pacientes con SPS evaluados en el Hospital Clínic de Barcelona entre los años 2005 y 2013. Resultados: la edad media al diagnóstico fue de 55 años y 41(61,2%) eran varones. El 67% (n = 45) eran fumadores. Veintisiete pacientes (40,3%) fueron derivados desde el programa de cribado poblacional de CCR. Se detectaron 1781 pólipos serrados (PS) y 298 adenomas en 268 colonoscopias y 23 piezas quirúrgicas (tiempo medio de seguimiento: 18 meses). El 76% tenía algún adenoma. Los PS se clasificaron en: 1048 pólipos hiperplásicos (PH), 724 adenomas serrados sésiles (ASS) y 9 adenomas serrados tradicionales. Un 4% de PS tenía displasia asociada. En 29 (43%) pacientes se utilizó cromoendoscopia, cuyo uso se asoció a una mayor detección de PS proximales y planos que la luz blanca (19,3 vs. 11,6; p = 0,05 y 11,2 vs. 3,5; p = 0.02, respectivamente). Trece individuos (19,4%) desarrollaron14 CCR (5 antes del diagnóstico de SPS, 5 simultáneamente y 3 durante el seguimiento). El desarrollo de CCR se asoció al número de ASS proximales (14 vs. 9,7; p = 0.03) y el sexo femenino (69,2% vs. 31,5%; p = 0,02). Diecisiete (25,4%) individuos requirieron cirugía por falta de control endoscópico. Conclusiones: El SPS confiere un alto riesgo de desarrollar CCR y adenomas. Los programas de cribado poblacional de CCR son clave para identificar pacientes con SPS. En nuestra población el sexo femenino y el número de ASS proximales se asociaron a mayor riesgo de CCR. La cromoendoscopia mejora la detección de PS planos y proximales.
Coupled-Wave Model for Square-Lattice 2D Photonic Crystal Distributed-Feedback Laser with TE-like Mode (2006)

We propose a coupled-wave model for square-lattice 2D photonic crystal distributed-feedback laser with transverse electric mode. It is shown that 2D optical coupling occurs among four lightwaves propagating in Γ-X direction through the higher-order waves propagating in Γ-M direction.
Microstrip and Printed Antenna Design (2019)

This thoroughly updated third edition of this popular book covers all types of printed microstrip antenna design, from rectangular to circular, broadband and dual band, and millimeter wave microstrip antenna to microstrip arrays. The book features new analysis of rectangular and circular microstrip antenna efficiency, and surface wave phenomena. Rectangular microstrip antenna cross polarization analysis and mitigation is expanded upon. Microstrip antenna array geometry options have been added to the text. The design of Vivaldi antennas has been revised and updated based on recent analysis. A chapter has been added which addresses design considerations for millimeter wave microstrip antennas and arrays. Sections addressing the design of shorted annular, patch-ring, corporate fed OMA, stripline series slot, inverted F, RFID Loop Coupler, CPW monopole, and characteristic mode antennas have been added. The appendices have been enlarged, and address PIM, efficiency computation, twin strip and parallel plate transmission line, the history of the decibel, return loss and reflection loss, new impedance matching methods, as well as a new appendix on baluns for printed antennas. Written with commercial applications in mind and aimed at practicing engineers, this book covers printed antennas and their design from the perspective of a seasoned consulting engineer who has worked many years in the field and has implemented all design concepts and technologies featured in the book and is essential reading for antenna designers and engineers.