gebhart/patrepeval huggingface dataset:
Ultrabrief Pulse Right Unilateral ECT: A New Standard of Care? (2009)

While ECT remains a remarkably safe and effective treatment for severe depression, its broad application has been hampered by concerns—both perceived and real—about its cognitive effects.5 Worries about memory loss make some patients reluctant to undergo this therapy and some practitioners reluctant to refer patients for it. Within the field of ECT itself, there has been tension for some years between the wish to maximize (the already excellent) antidepressant and antipsychotic efficacy of ECT and the competing wish to minimize any effects on memory.
Ambiguity in the m-bonacci numeration system (2007)

We study the properties of the function R (m) (n) defined as the number of representations of an integer n as a sum of distinct m-Bonacci numbers F (m) k, given by F i (m) =2 i-1, for i∈ { 1, 2, …, m}, F k+m (m) =F k+m-1 (m) +F k+m-2 (m) + ⋯ + F k (m), for k ≥ 1. We give a matrix formula for calculating R (m) (n) from the greedy expansion of n. We determine the maximum of R (m) (n) for n with greedy expansion of fixed length k, i.e. for F (m) k ≤ n&lt;F (m) k+1. Unlike the Fibonacci case m=2, the values of the maxima are not related to the sequence (F (m) k) k ≥ 1. We describe the palindromic structure of the sequence (R (m) (n)) n ∈ ℕ, which is richer than in the case of Fibonacci numeration system.
IMMU-20. HYDROGEL-CXCL9 VACCINE RESULTS IN MRNA DELIVERY TO DENDRITIC CELLS AND POTENT ANTI-TUMOR RESPONSES IN GBM (2021)

Abstract INTRODUCTION Our group and others have shown mRNA-vaccines have significant anti-tumor efficacy in the treatment of brain tumors and are currently being tested in first-in-human trials. To further enhance mRNA delivery, a hydrogel platform was developed with the addition of CXCL9 to promote immune cell trafficking. METHODS We generated the vaccine by utilizing a hydrogel platform. CXCL9 and Nano-mRNA were loaded into the hydrogel. In vitro recruitment of DCs and NK was evaluated by fluorescence microscopy. In vivo recruitment of immune cells was analyzed by flowcytometry after collecting the fat pad, spleen, and tumor samples from KR158b-luc and Gl261-gp100 tumor-bearing animals 3, 5 and 10 days after vaccine delivery. The efficacy of the vaccine was evaluated by measuring overall survival, and tumor growth was measured by IVIS live-imaging. RESULTS Dendritic cells(DCs) and natural killer(NK) cells were able to efficiently migrate within the hydrogel-CXCL9 platform and uptake and express mRNA in vivo. In vitro, the hydrogel-CXCL9 was combined with nanoparticles loaded with total tumor RNA, and the vaccine was delivered to KR-158-luc and GL261-gp100 tumor-bearing animals via mammary fat pad SQ injection. Flow cytometry of the fat pad and draining lymph nodes demonstrated showed significant recruitment of endogenous DCs including inflammatory-DC(P= 0.0035), conventional-DC1(P= 0.0076), pDC(P=0.0028), NK(p= 0.0025 compared to the control group. In two different tumor models, a single dose of the vaccine resulted in significant survival benefits compared to control animals (n=10,P&amp;lt; 0.0001). SQ injection was superior to intracranial injection of the vaccine. Vaccinated animals showed an increased number of antigen-specific CD8 T cells in spleen(P= 0.0001) and tumor-microenvironment(P= 0.0070). CONCLUSION The hydrogel-CXCL9 platform results in efficient delivery of mRNA loaded nanoparticles to endogenous DCs and also causes an upregulation of NK cells with resultant improved survival in murine GBM models including the highly resistant KR158 model with a single dose. Further studies are ongoing.
Degradation and lifetime estimation of n-MOS SLS ELA polycrystalline TFTs during hot carrier stressing: effect of channel width in the regionVth⩽VGS,stress⩽VDS,stress/2 (2009)

The voltage bias stress induced degradation of sequential lateral solidification (SLS) polysilicon thin film transistors (TFTs) is studied. The aim of this work is the investigation of the types of damage arising from the electrical stressing in the gate voltage range around Vth VGS,stress VDS,stress/2 and for different drain-bias voltages. It is shown that the drain on-current variation (%) with stressing time for a defined gate voltage obeys a power‐time-dependent law of the form At n . The parameters A and n of this law were determined in order to gain insight on degradation mechanisms in different stress regimes and to estimate the time to failure of our devices. Devices with different channel widths were compared, and their lifetime to failure was extracted. It was found that the magnitude of stress was lower for devices with narrower channel widths. By monitoring the threshold voltage variation and the percentage change of transconductance maximum in the linear regime of operation, it was verified that the threshold voltage degradation was mainly due to the contribution of Gm,max to Vth rather than severe carrier trapping.
Complexation of Bioreducible Cationic Polymers with Gold Nanoparticles for Improving Stability in Serum and Application on Nonviral Gene Delivery (2015)

Widespread applications of conventional polymeric gene carriers are greatly hampered by their inefficient transfection performance under serum-containing environment. Aiming to overcome this limitation, we propose a bioreducible polyethylenimine-gold nanocomplex system (SSPEI-Au NC), which can be prepared by a simple layer-by-layer (LBL) assembly procedure. SSPEI-Au NC contains sequentially deposited layers of bioreducible polyethylenimine (SSPEI) and poly(γ-glutamic acid) (γ-PGA) for efficient binding and delivery of plasmid DNA (pDNA). SSPEI-Au NC was characterized for various physicochemical properties, including: UV-vis spectra, TEM imaging, hydrodynamic size, and pDNA binding ability. The SSPEI-Au NC were efficiently uptaken by mammalian cells as observed using dark-field microscopy. Comparing to nondegradable PEI25k, the bioreducible SSPEI-Au NC exhibited superior transfection capability under serum-containing condition while causing lower cytotoxicity on mammalian cell lines. The effect of serum on SSPEI-Au NC dispersity was studied using UV-vis spectrometry and the results suggest that serum-assisted colloidal stability of SSPEI-Au NC contributed to its serum-resistant transfection.
Layered water in crystal interfaces as source for bone viscoelasticity: arguments from a multiscale approach (2012)

Extracellular bone material can be characterised as a nanocomposite where, in a liquid environment, nanometre-sized hydroxyapatite crystals precipitate within as well as between long fibre-like collagen fibrils (with diameters in the 100 nm range), as evidenced from neutron diffraction and transmission electron microscopy. Accordingly, these crystals are referred to as 'interfibrillar mineral' and 'extrafibrillar mineral', respectively. From a topological viewpoint, it is probable that the mineralisations start on the surfaces of the collagen fibrils ('mineral-encrusted fibrils'), from where the crystals grow both into the fibril and into the extrafibrillar space. Since the mineral concentration depends on the pore spaces within the fibrils and between the fibrils (there is more space between them), the majority of the crystals (but clearly not all of them) typically lie in the extrafibrillar space. There, larger crystal agglomerations or clusters, spanning tens to hundreds of nanometers, develop in the course of mineralisation, and the micromechanics community has identified the pivotal role, which this extrafibrillar mineral plays for tissue elasticity. In such extrafibrillar crystal agglomerates, single crystals are stuck together, their surfaces being covered with very thin water layers. Recently, the latter have caught our interest regarding strength properties (Fritsch et al. 2009 J Theor Biol. 260(2): 230-252) - we have identified these water layers as weak interfaces in the extrafibrillar mineral of bone. Rate-independent gliding effects of crystals along the aforementioned interfaces, once an elastic threshold is surpassed, can be related to overall elastoplastic material behaviour of the hierarchical material 'bone'. Extending this idea, the present paper is devoted to viscous gliding along these interfaces, expressing itself, at the macroscale, in the well-known experimentally evidenced phenomenon of bone viscoelasticity. In this context, a multiscale homogenisation scheme is extended to viscoelasticity, mineral-cluster-specific creep parameters are identified from three-point bending tests on hydrated bone samples, and the model is validated by statistically and physically independent experiments on partially dried samples. We expect this model to be relevant when it comes to prediction of time-dependent phenomena, e.g. in the context of bone remodelling.
Supplementary Materials and Methods, Figure Legends 1-5 from Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy (2023)

Supplementary Materials and Methods, Figure Legends 1-5 from Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy
A Novel Vector for Positive Selection of Inserts Harboring an Open Reading Frame by Translational Coupling (2007)

We have developed a novel vector pTCS, as a tool for efficient selection of open reading frame (ORF)-containing inserts. In pTCS clones containing an insert with an ORF a downstream marker gene (immE3, conferring resistance to colicin) is activated via translational coupling with the insert, and transformed cells can then be selected by exposure to colicin E3. Our method differs from previous methods in that the marker gene is activated without protein fusion, and that selection occurs irrespective of the reading frame of the insert.
Phase behavior of coal fluids: Data for correlation development (1990)

The effective design and operation of processes for conversion of coal to fluid fuels requires accurate knowledge of the phase behavior of the fluid mixtures encountered in the conversion process. The overall objective of the author's work is to develop accurate predictive methods for representation of vapor-liquid equilibria in systems encountered in coal conversion processes. The objectives of the present project include: (1) measurements of binary vapor-liquid phase behavior data for selected solute gases (e.g. CO{sub 2} and C{sub 2}H{sub 6}) in a series of heavy hydrocarbon solvents to permit evaluation of interaction parameters in models for phase behavior, (2) measurements on ternary systems in which high-melting-point solvents are dissolved in more volatile aromatics to provide mixed solvents, (3) evaluation of existing equations-of-state and other models for representation of phase behavior in systems of the type studied experimentally; development of new correlation frameworks as needed, and (4) generalization of the interaction parameters for the solutes studied to a wide spectrum of heavy solvents; presentations of final results in formats useful in the design/optimization of coal liquefaction processes. This quarter, our framework for correlating saturation properties using a scaled-variable-reduced-coordinate'' approach was further developed to provide for generalized vapor pressure predictions. 59 refs., 6 figs., 8 tabs.
étude d'éléments de base et de concepts pour un numériseur à très large bande passante et à haute résolution (2007)

La numérisation de plus en plus rapide de signaux à très large bande-passante permet aujourd'hui d'envisager de nombreuses applications pour les systèmes de télécommunication, les mesures expérimentales ou les systèmes radar. Les signaux issus des capteurs peuvent être analysés directement, en évitant la conversion en fréquences intermédiaires. Dans ce travail, nous nous intéressons plus particulièrement au système d'échantillonnage pour des applications radar, qui nécessitent une amélioration significative de la résolution des systèmes existants. L'objectif que nous visons inclus les spécifications suivantes : une fréquence d'échantillonnage de 40 GEch/s, une bande-passante supérieure à 15 GHz et une résolution de 10 bits effectifs à 8 GHz. Partant des excellents résultats obtenus sur les architectures mono-coup à entrelacement temporel, nous avons choisi d'adapter leur principe à un fonctionnement répétitif. Nous avons aussi choisi de baser cette étude sur la technologie TBH sur InP car elle présente les meilleures potentialités pour notre application. Deux éléments de base de ces systèmes ont fait l'objet d'une optimisation particulière pour améliorer la résolution du système : l'inverseur pour minimiser le jitter et l'échantillonneur-bloqueur, principalement pour améliorer la linéarité. Partant de ces résultats, trois architectures innovantes ont été proposées. Pour chacune nous avons conçu un système dont nous avons simulé les performances
Feature subset selection for Arabic document categorization using BPSO-KNN (2011)

Document categorization is an important topic that is central to many applications that demand reasoning about and organisation of text documents, web pages, and so forth. Document classification is commonly achieved by choosing appropriate features (terms) and building a term-frequency inerse-document frequency (TFIDF) feature vector. In this process, feature selection is a key factor in the accuracy and effectiveness of resulting classifications. For a given task, the right choice of features means accurate classification with suitable levels of computational efficiency. Meanwhile, most document classification work is based on English language documents. In this paper we make three main contributions: (i) we demonstrate successful document classification in the context of Arabic documents (although previous work has demonstrated text classification in Arabic, the datasets used, and the experimental setup, have not been revealed); (ii) we offer our datasets to enable other researchers to compare directly with our results; (iii) we demonstrate a combination of Binary PSO and K nearest neighbour that performs well in selecting good sets of features for this task.
Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase) (1998)

The stratum corneum of the skin serves as an effective barrier for maintenance of the internal milieu against the external environment. At the cell periphery of the stratum corneum is the cell envelope, a highly insoluble membranous structure composed of precursor proteins cross-linked by epsilon-(gamma-glutamyl)lysine bonds. Transglutaminase 1 (TGase 1; keratinocyte TGase), a membrane-bound isozyme of the TGase family, has been proposed to catalyze this process of assembly. Deficient cross-linking of the cell envelope in some patients with the autosomal recessive skin disorder lamellar ichthyosis (LI) and several mutations of the TGase 1 gene that have been identified in families with LI suggest the importance of this gene in production of the cell envelope. In this study, we generated mice lacking the TGase 1 gene, and we report that they have erythrodermic skin with abnormal keratinization. In their stratum corneum, degradation of nuclei and keratohyalin F-granules was incomplete and cell envelope assembly was defective. The skin barrier function of TGase 1-null mice was markedly impaired, and these mice died within 4-5 h after birth. These results clearly demonstrate that the TGase 1 gene is essential to the development and maturation of the stratum corneum and to adaptation to the environment after birth. Thus, these TGase 1 knockout mice may be a useful model for severe cases of LI.
Adapting a Capillary Rheometer for Research on Polymer Melt Interfaces (2018)

Interfaces between immiscible polymers are widely known to be the origin of premature failure in multilayers and blends. Developing a small-scale, continuous method to fabricate interfaces from polymer melts with short contact times to simulate industrial coextrusion is critical for assessing new materials, polymeric systems, and processing conditions. Here we develop a miniature coextrusion die that can be fitted to a twin bore capillary rheometer for precise temperature and contact time control from 4.4 to 440 s. The design of the feedblock, stacker, manifold, and land zones was optimized via flow simulation software to allow bilayer coextrusion with minimal (<10%) edge distortions. Bilayer films of isotactic polypropylene (iPP) and polyethylene (PE) were produced using 90% less material than a lab-scale continuous multilayer coextrusion device, and the interfacial adhesion was in excellent agreement with iPP/PE bilayers produced using a continuous coextrusion technique for a range of PE molecular architectures. Finally, poly(ethylene terephthalate) (PET) and maleic anhydride grafted PE were coextruded. With a melt interfacial contact time of 22 s, interfacial adhesion between functionalized PE (both 0.8 and 1.5 wt %) and PET increased at least 30-fold over nonfunctionalized PE and PET. Using a moderate anhydride grafting density (0.8 wt %), interfacial adhesion also increased by a factor of 10 when interfacial contact time was increased from 4.4 to 22 s. The die designed here represents a convenient and accessible method to screen interfacial adhesion using less than 50 g of material, ideal for assessing new polymers synthesized at small scale.
On the Small-Sample Properties of the Olkin-Sobel-Tong Estimator of the Probability of Correct Selection (1983)

Abstract In the problem of selecting the best of k populations, Olkin, Sobel, and Tong (1976) have introduced the important idea of a posteriori analysis of the data (as opposed to the usual formulation), in which design of the experiment is the major consideration. They considered the large-sample properties of an estimator that has been discussed further by Gibbons, Olkin, and Sobel (1977), Gupta and Panchapakesan (1979), and Tong (1980). In this article we study the small-sample performance of the Olkin, Sobel, and Tong estimator, analytically for k = 2 populations and via Monte Carlo simulation for k ≥ 2 populations in the normal means, common, known variance case. This small-sample performance is found to have some serious shortcomings.
ClearSee: a rapid optical clearing reagent for whole-plant fluorescence imaging (2015)

Imaging techniques for visualizing and analyzing precise morphology and gene expression patterns are essential for understanding biological processes during development in all organisms. With the aid of chemical screening, we developed a clearing method using chemical solutions, termed ClearSee, for deep imaging of morphology and gene expression in plant tissues. ClearSee rapidly diminishes chlorophyll autofluorescence while maintaining fluorescent protein stability. By adjusting the refractive index mismatch, whole-organ and whole-plant imaging can be performed by both confocal and two-photon excitation microscopy in ClearSee-treated samples. Moreover, ClearSee is applicable to multicolor imaging of fluorescent proteins to allow structural analysis of multiple gene expression. Given that ClearSee is compatible with staining by chemical dyes, the technique is useful for deep imaging in conjunction with genetic markers and for plant species not amenable to transgenic approaches. This method is useful for whole imaging for intact morphology and will help to accelerate the discovery of new phenomena in plant biological research.
Azacitidine Is Effective in Patients with Low / Intermediate-1 Risk Myelodysplastic Syndrome Managed in Community Based Practice: Preliminary Data From the Spanish Compassionate Use Registry. (2009)

Abstract Abstract 3801 Poster Board III-737 Background Myelodysplastic syndrome (MDS) is comprised of a group of heterogeneous hematological disorders. Although the decision regarding treatment of a patient with MDS is based on performance status, age, patient preference and concomitant illnesses, NCCN-recommended treatment approaches vary according to IPSS risk score. Azacitidine (AZA) is a hypomethylating agent recently approved in Europe for the treatment of MDS. AZA was available in Spain under compassionate use before its regulatory approval and marketing authorization from the Spanish Medicines Agency in May 2009. Material and Methods We present the preliminary analysis of the clinical data from a longitudinal, multicenter Spanish patient registry. Data on the disease course and management of patients with MDS treated with AZA under compassionate use conditions were retrospectively collected from community-based hematology clinics. As of August 1, 2009, data from 90 patients MDS diagnosed according to WHO criteria had been collected with low / intermediate-1 International Prognostic Scoring System (IPSS) risk score. Results At baseline, the median age was 70 years, the male/female ratio was 69/31, and the majority of patients had primary MDS (80 patients; 90%) and an ECOG performance status of 0-1 (62 patients; 69%). The most frequent initial dose of AZA administered was 75 mg/m2 (77 patients, 86%). Almost all patients followed one of the following three schedules: days 1-7 (31%), days 1-5 and 8-9 (29%) or days 1-5 (37%) in a 28-day cycle. AZA was administered mostly subcutaneously (71 patients, 79%). The mean number of cycles administered was 7 (range 2-25). The overall treatment response was 61% (International Working Group 2006 criteria): 21% complete response, 11% complete bone marrow response, 3% partial response, 27% hematological response. In addition, 12% had stable disease. AZA was generally well tolerated. Grade 3/4 adverse events documented in these patients, regardless of their relationship to the active treatment, were neutropenia (48%), thrombocytopenia (36%), anemia (26%), febrile neutropenia (12%), rash (3%), injection site reaction (2%), asthenia (1%), septic shock (1%), constitutional symptoms (1%), and hypotension (1%). Conclusion These preliminary results demonstrate that, in a community-based setting, patients with low / intermediate-1 IPSS risk MDS respond to treatment with AZA, with an acceptable safety profile. More data derived from this registry and from the clinical trials are awaited. Disclosures: No relevant conflicts of interest to declare.
"Static" modes in the full-wave analysis of printed antennas (2002)

A novel approach is applied to the EFIE-MoM analysis of printed antennas, based on the eigenfunctions of suitably extracted singular, frequency-independent parts of the integral operator. These terms, called "static modes", are entire-domain basis functions that extend and generalise the TM and TE modes of a magnetic-wall cavity to arbitrary geometries. General criteria allow to select those modes that efficiently represent the solution, including also "attachment" modes that represent the feed structure discontinuities.