gebhart/patrepeval huggingface dataset:
Nanotechnology in therapeutics : current technology and applications (2007)

Section A: Intelligent Therapeutics and Responsive Delivery Systems for Improved Absorption and Delivery A1. Concepts of Medical Chronobiology, Chronopharmacology and Chronotherapeutics as the Basis for Applications of Drug Delivery Technology A2. Feedback Control in Drug Delivery A3. Advances in Drug Delivery Technologies for Nanoparticulates A4. Synthetic Ligand-Receptor Interactions In Delivery Systems A5. Nanoscale Analysis of Mucus-Carrier Interactions for Improved Drug Absorption A6. Polymeric Gene Delivery Vectors Section B: Therapeutic Micro- and Nanodevices B1. Biohybrid Materials for Therapeutic Devices Section C: Nanostructured Therapeutic Materials C1. Biomimetic Systems: A Synergy of Scientific and Engineering Approaches C2. Hydrogel Nanocomposites For Intelligent Therapeutics C3. Nanotechnology for Treating Bone Disorders C4. Nanotechnology And Cancer Therapy C5. Nanostructured Scaffolds for Tissue Engineering Section D: Nanoparticulate Systems in Intelligent Therapy D1. Star Polymers and Dendrimers in Nanotechnology and Drug Delivery D2. Ionic Nanoparticulate Systems for Drug Delivery D3. Nanospheres of Intelligent Networks for Biomedical and Drug Delivery Applications D4. Shell Crosslinked Nanoparticles: A Progress Report of Their Design for Drug Delivery D5. Nanoparticulate Structures in Diabetes Treatment
Randomized double‐blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites (2006)

Sublingual immunotherapy was clinically effective and safe in mite-induced mild disease.
Hierarchical hybrid neuromorphic control for robotic motions-sensing, recognition, planning, adaptation, and learning (2002)

The authors present a scheme for intelligent control of robotic manipulators. This control system is analogous to the human cerebral control system. It is a hybrid system of neuromorphic control and symbolic control that includes a neural network for servo control and knowledge-based approximation. The neural network at the servo control level is used for numerical manipulation, while the knowledge-based component is used for the symbolic manipulation. In neuromorphic control, the neural network compensates for the nonlinearity of the system and the uncertainty in the environment. The knowledge base component makes the control strategy in a symbolical manner for the servo level. Simulation and experimental results are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data (2008)

ReplicationDomain is a novel and powerful tool to facilitate the comparative visualization of replication timing in various cell types as well as other genome-wide chromatin features and is considerably faster and more convenient than existing browsers when viewing multi-megabase segments of chromosomes. Furthermore, the data upload function with the option of private viewing or sharing of data sets between registered users should be a valuable resource for the scientific community.
Effect of Boron and Oxygen on the Structure and Properties of Protective Decorative Cr–Al–Ti–N Coatings Deposited by Closed Field Unbalanced Magnetron Sputtering (CFUBMS) (2019)

Boron and oxygen-doped Cr–Al–Ti–N coatings were deposited by closed field unbalanced magnetron sputtering (CFUBMS) of TiB target manufactured by self-propagating high-temperature synthesis, and Ti, Cr, and Al targets. To evaluate the influence of doping elements, as-deposited coatings were studied by glow discharge optical emission spectroscopy (GDOES), SEM, XRD, and optical profilometry. Mechanical properties were measured by nanoindentation and tribological, abrasive and electrochemical testing. The introduction of boron suppresses columnar growth and leads to structural refinement and a decrease of coating’s surface roughness. The addition of 2.3 at.% boron results in the highest mechanical properties: hardness H = 15 GPa, stable friction coefficient f = 0.65, and specific wear Vw = 7.5 × 10−6 mm3N−1m−1. To make the coating more visually appealing, oxygen was introduced in the chamber near the end of the deposition cycle. Upper Cr–Al–Ti–B–O–N layers were studied in terms of their composition and coloration, and the developed two-layer decorative coatings were deposited on cast metallic art pieces.
Characterizing In Vivo Pharmacodynamics of Carbapenems against Acinetobacter baumannii in a Murine Thigh Infection Model To Support Breakpoint Determinations (2013)

Pharmacodynamic profiling data of carbapenems for Acinetobacter spp. are sparse. This study aimed to determine the pharmacodynamic targets of carbapenems for Acinetobacter baumannii based on a range of percentages of the dosing interval in which free drug concentrations remained above the MIC (fT>MIC) in the neutropenic murine thigh infection model. fT>MIC values of 23.7%, 32.8%, and 47.5% resulted in stasis, 1-log reductions, and 2-log reductions in bacterial density after 24 h, respectively. The pharmacodynamic targets of carbapenems for A. baumannii demonstrated in vivo are similar to those of other Gram-negative bacteria.
A Probabilistic Time Reversal Theorem (Poster) (2018)

Combining independent observations is commonly performed by using a least squares technique, as it is thought that this is necessary to achieve an optimal solution. The purpose of this article is to show that this is not always the case. The particular example combines observations that are exponentially distributed. One application of this technique is to determine the time of a singular event which initiated a set of decay processes having known half-lives. The time of the singular event decays backwards in time with an exponential distribution. We find that the accuracy of this method is significantly better than the accuracy of a least squares technique. The improved accuracy can be important for applications that require combining many noisy observations, such as situation awareness.
Quantitative fluorescence flow cytometry: A comparison of the three techniques for direct and indirect immunofluorescence (1998)

Three types of microbead calibrators available for quantitative fluorescence flow cytometry have been studied in parallel using a variety of monoclonal antibodies (MoAbs). The QIFI kit is designed for indirect immunofluorescence (IF), and both the Quantum Simply Cellular (QSC) assay and the Quanti-BRITE assay are designed for direct IF. Because of the different nature of the respective ligands, epitopes on cells versus F'ab-portions on QSC beads, large differences in titration curves for a large number of CD MoAbs were noted between QSC beads and cells. Use of the QSC assay and fluorescein isothiocyanate (FITC) and phycoerythrin (PE) conjugates of the same CD reagent revealed substantially different numbers of cellular binding sites. Numbers of cellular binding sites as determined by direct IF using the Quanti-BRITE assay and by indirect IF using the QIFI kit were similar. We also found that erythrocyte (RBC)-lysing reagents cause varying and sometimes substantial reduction in the fluorescence intensity (FI) of cells stained directly with CD34 MoAb conjugates, but the RBC-lysing reagents had no effect on the FI of cells stained indirectly with the same CD34 MoAbs. This report defines a number of variables critical for standardized quantitative flow cytometry. We conclude that the choice of calibrators, fluorochrome conjugates, staining methods, and modes of sample processing can effect the determination of cellular binding sites to MoAbs. Direct immunofluorescence using the Quanti-BRITE assay and indirect IF using the QIFI kit appear to yield comparable results for the standardized determination of numbers of cellular binding sites to MoAbs.
Why new test conditions for laser guard (2011)

A variety of exposure limit tests with different materials and lasers led to non reproducible results, which can lead to false interpretation concerning the exposure limit and overestimated lifetime predictions of laser guards. This lecture describes some of the most important factors of false interpretations
Optimal strategies for targeted influence in signed networks (2014)

Online social communities often exhibit complex relationship structures, ranging from close friends to political rivals. As a result, persons are influenced by their friends and foes differently. Network applications can benefit from accompanying these structural differences in propagation schemes. In this paper, we study the optimal influence propagation policies for networks with positive and negative relationship types. We tackle the problem of minimizing the end-to-end propagation cost of influencing a target person in favor of an idea by utilizing the relationship types in the underlying social graph. The propagation cost is incurred by social and physical network dynamics such as frequency of interaction, the strength of friendship and foe ties, propagation delay or the impact factor of the propagating idea. We extend this problem by incorporating the impact of message deterioration and ignorance. We demonstrate our results in both a controlled environment and the Epinions dataset. Our results show that judicious propagation schemes lead to a significant reduction in the average cost and complexity of influence propagation compared to naïve myopic algorithms.
Selective-Area Atomic Layer Deposition Using Poly(methyl methacrylate) Films as Mask Layers (2008)

Selective-area atomic layer deposition (ALD) was achieved using poly(methyl methacrylate) (PMMA) films as growth inhibiting mask layers. The PMMA films were prepared from PMMA−toluene solution by spin-coating and patterned by UV lithography through a mechanical mask. The patterned PMMA films were tested in several ALD processes, both noble metals and oxides. The tested noble metal processes were iridium, platinum, and ruthenium, and the oxide processes were Al2O3 and TiO2. Al2O3 was deposited using AlCl3 and H2O and trimethylaluminum (TMA) and H2O. TiO2 was deposited using Ti(OMe)4 and H2O. The growth temperatures were 250−350 °C.
Effect of Thickness of Structural Ultra Thick Steel Plates on their Weldability (1959)

Tensile and impact specimens to two kinds of project steels were tested to determine the effect of rolled plate thickness on the mechanical properties and notch toughness. These steel plates, containing the thickness, 12, 20, 25, 35, 50, 65 and 80 mm, were rolled from two different charges. One of them has the chemical compositions of the mild steel, C class of ABS (tested in both as rolled and normalized conditions) and the auther has those of high tensile steel (fabricated after quenching and tempering process).To estimate the effect of plate thickness on mechanical properties, the full thickness tension specimen of JIS classification and micro tension specimen were used, and also, to evaluate the notch toughness affected by thickness the standard and full thickness V notched Charpy specimens and Van der Veen specimens of full thickness were used.As a result, the conclustions were summarized as follows;(1) It was recognized that there was, at least, one "transition thickness" for the notch toughness of steel rolled out in the range of thickness from 12 mm to 80 mm. The "transition thickness" depended upon the kind of steel.(2) In the case of mild steel, any significant effect of thickness was not obtained on the mechanical properties. On the contrary, the roll finish thickness has influence on the notch toughness. In the range of thickness exceeding 50 mm, the toughness was remarkably lowered, in consequence, in order to apply this range of steel plate to actual steel constructions, further devices would be needed in heat treatment and determing of steel compositions. However, the notch toughness of mild steel plate, 50 mm thick, corresponded to that of plate, . 35 mm thick, when the plate was normalized after rolling.(3) In the quenched and tempered steel (high tensile steel) whose thickness exceeds 25 mm, the steel quality and heat tratment process should be determined very cautiously to improve their emechanical properties and notch toughness. The notch toughness of this quenched and temperfd high tensile steel, in spite of the decrease of the tohghess as the increase of thickness, whose thickness exceeds 35 mm, corresponded to that of the normalized mild steel.
Membrane Reactor for Methanol Synthesis Using Si-Rich LTA Zeolite Membrane (2021)

We successfully demonstrated the effect of a membrane reactor for methanol synthesis to improve one-pass CO<sub>2</sub> conversion. An Si-rich LTA membrane for dehydration from a methanol synthesis reaction field was synthesized by the seed-assisted hydrothermal synthesis method. The H<sub>2</sub>O permselective performance of the membrane showed 1.5 × 10<sup>-6</sup> mol m<sup>-2</sup> s<sup>-1</sup> Pa<sup>-1</sup> as H<sub>2</sub>O permeance and around 2000 as selectivity of H<sub>2</sub>O/MeOH at 473 K. From the results of membrane reactor tests, the CO<sub>2</sub> conversion of the membrane reactor was higher than that of the conventional packed-bed reactor under the all of experimental conditions. Especially, at 4 MPa of reaction pressure, the conversion using the membrane reactor was around 60%. In the case of using a packed-bed reactor, the conversion was 20% under the same conditions. In addition, the calculated and experimental conversion were in good agreement in both the case of the membrane reactor and packed-bed reactor.
Fabrication and Properties of Copper/Carbon Composites for Thermal Management Applications (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Combination Treatment of Renal Cell Carcinoma with Belinostat and 5-Fluorouracil: A Role for Oxidative Stress Induced DNA Damage and HSP90 Regulated Thymidine Synthase (2014)

In combination with 5-fluorouracil the targeted inhibitor of histone deacetylase synergistically inhibited renal cancer cell growth by the blockade of thymidylate synthase induction and the induction of reactive oxygen species mediated DNA damage in vitro and in vivo. Our results suggest that combined treatment with belinostat and 5-fluorouracil may represent a promising new approach to renal cancer.
Inverse Problems for Discrete Heat Equations and Random Walks for a Class of Graphs (2023)

.We study the inverse problem of determining a finite weighted graph \((X,E)\) from the source-to-solution map on a vertex subset \(B\subset X\) for heat equations on graphs, where the time variable can be either discrete or continuous. We prove that this problem is equivalent to the discrete version of the inverse interior spectral problem, provided that there does not exist a nonzero eigenfunction of the weighted graph Laplacian vanishing identically on \(B\) . In particular, we consider inverse problems for discrete-time random walks on finite graphs. We show that under a novel geometric condition (called the Two-Points Condition), the graph structure and the transition matrix of the random walk can be uniquely recovered from the distributions of the first passing times on \(B\) , or from the observation on \(B\) of one realization of the random walk.Keywordsinverse problem for random walkinverse spectral problemheat equationunique continuationMSC codes05C5005C8105C22
Determination and validation of water droplet size distributions probed by cavity enhanced Raman scattering (2003)

Cavity enhanced Raman scattering (CERS) fingerprints are obtained on a single particle basis, providing a spectroscopic signature of the water droplet sizes generated by a vibrating orifice aerosol generator (VOAG). By sampling the aerosol train generated by the VOAG over a period of seconds, the size distribution of water droplets can be accumulated. The objective of this paper is to validate the size distribution measurements made and to quantify the accuracy of the sizes measured, along with providing an examination of the dependence of the CERS fingerprint on illumination geometry and laser pulse energy. The size distribution measurements are verified by elastic light scattering data, confirming both the sizes measured by CERS and the evolving droplet sizes produced by the VOAG during an operating time of 5 min. The experimental limitations imposed on the accuracy of the sizes measured by CERS are discussed and estimated. The estimated uncertainty in the droplet radius increases from 4 nm for a 10 μm radius droplet to 22 nm for a 50 μm radius droplet.
Attribution Issues in Cyberspace (2013)

This article discusses one of the problems with the current condition of the international attribution regime.The rise of non-state actors in international and internal conflicts has created many problems for the international community.This is especially true in the case of cyber attacks.The tests for attributing the actions of a non-state actor to a state were devised before the age of the Internet and before cyber attacks accompanied armed attacks.The entities that conceived the attribution tests were unable to factor cyber attacks into their considerations because, in large part, the ability to conduct a cyber attack had yet to be developed.Cyber attacks can have a devastating impact on a state's economy and infrastructure.Because new technological developments allow non-state actors to launch cyber attacks, especially those implemented in conjunction with armed attacks, as was the case in Georgia in 2008, the international community should reassess where it stands on the issue of attribution.This article uses the Georgia-Russia conflict as a window into the problems of attribution.It examines the attribution tests set forth in the International Court of Justice's Nicaragua decision, the International Criminal Tribunal for the Former Yugoslavia's Tadi! decision, and Article 8 of the Draft Articles on Responsibility for Internationally Wrongful Acts.This article calls on the relevant parties to set a lower standard for attribution,
Liquid chromatography with pulsed electrochemical detection at gold and platinum electrodes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid Chromatography with Pulsed Electrochemical Detection at Gold and Platinum ElectrodesDennis C. Johnson and William R. LaCourseCite this: Anal. Chem. 1990, 62, 10, 589A–597APublication Date (Print):May 15, 1990Publication History Published online30 May 2012Published inissue 15 May 1990https://pubs.acs.org/doi/10.1021/ac00209a715https://doi.org/10.1021/ac00209a715research-articleACS PublicationsRequest reuse permissionsArticle Views845Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Shepherding the crowd (2011)

Micro-task platforms provide a marketplace for hiring people to do short-term work for small payments. Requesters often struggle to obtain high-quality results, especially on content-creation tasks, because work cannot be easily verified and workers can move to other tasks without consequence. Such platforms provide little opportunity for workers to reflect and improve their task performance. Timely and task-specific feedback can help crowd workers learn, persist, and produce better results. We analyze the design space for crowd feedback and introduce Shepherd, a prototype system for visualizing crowd work, providing feedback, and promoting workers into shepherding roles. This paper describes our current progress and our plans for system development and evaluation.
Audiologic limitations of Vibrant Soundbridge device: Is the contralateral hearing aid fitting indispensable? (2016)

4 Laryngoscope, 126:2116-2123, 2016.
Two MicroRNA Panels to Discriminate Three Subtypes of Lung Carcinoma in Bronchial Brushing Specimens (2012)

We found two microRNA panels that accurately discriminated between the three subtypes of lung carcinoma in bronchial brushing specimens. The identified microRNA panels may have considerable clinical value in differential diagnosis and optimizing treatment strategies based on lung cancer subtypes.
Cover story: The colourful character of APY (2012)

The end of an adventure SAPOL Det-Brevet Matthew Buck talks to Kristi High about the landscape, lifestyle and colourful characters of APY Lands after spending 18 months working in one of the most remote parts of our vast country.
A Computational Predictive Approach for Controlling the Morphology of Functional Molecular Aggregates on Substrates (2019)

Abstract Full control of the growth dynamics and morphology of nanoscale molecular aggregates on substrates is a crucial factor for the development of novel materials and devices for technological applications. A novel computational approach based on molecular dynamics, which is able to predict the structure of nanoscale aggregates of organic small molecules on substrates as a function of growth and processing conditions, is presented. In the simulation protocol proposed, molecules are progressively added to the substrate, one by one, reproducing vacuum thermal deposition processes. The simulation parameters affect the structure of the configuration, and formation of molecular aggregates is spontaneously observed upon reaching a critical molecular density at the interface. Suitable simulation parameters allow to access different molecular aggregation morphologies on substrates, including crystalline phases, matching the structural variability observed in real fabrication conditions. This approach is benchmarked by simulating the morphology of aggregates of N , N ′‐ditridecylperylene‐3,4,9,10‐tetracarboxylic diimide (PTCDI‐C13), a prototypical n‐type semiconductor for organic electronics, on graphene, in different growth conditions. Simulations predict structural features of aggregates of PTCDI‐C13 on graphene that are in excellent agreement with experiments and, at the same time, provide a rationale and quantitative relationship between molecular structure and observed aggregation morphologies.