gebhart/patrepeval huggingface dataset:
Irreversible Enzyme Inhibitors. CVI.1 Proteolytic Enzymes. I. Bulk Tolerances in Trypsin-Inhibitor Complexes2 (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible Enzyme Inhibitors. CVI.1 Proteolytic Enzymes. I. Bulk Tolerances in Trypsin-Inhibitor Complexes2B. R. Baker and Edward H. EricksonCite this: J. Med. Chem. 1967, 10, 6, 1123–1128Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jm00318a030https://doi.org/10.1021/jm00318a030research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lower health-related quality of life predicts all-cause hospitalization among HIV-infected individuals (2018)

After controlling for factors associated with hospitalization among those with HIV, both PCSS and MCSS were predictive of all-cause hospitalization in the NHS cohort. HRQOL assessment using the SF-36 may be useful in stratifying hospitalization risk among HIV-infected populations.
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer (1999)

EEA1, an early-endosomal protein originally identified as an autoantigen, is essential for endocytic membrane fusion. It interacts with early endosomes via binding to the membrane lipid phosphatidylinositol 3-phosphate (PtdIns3P) and the active form of the small GTPase Rab5. Most of the EEA1 sequence contains heptad repeats characteristic of proteins involved in coiled-coil protein–protein interactions. Here we have investigated the ability of EEA1 to self-interact. Crosslinking of cytosolic and recombinant EEA1 resulted in the disappearance of the 180-kDa monomer in SDS/PAGE and the strong appearance of a ∼ 350-kDa crosslinked product. Glycerol gradient centrifugation experiments indicated that native EEA1 had the same hydrodynamic properties as the ∼ 350-kDa crosslinked complex. Two-hybrid analysis indicated that N- and C-terminal fragments of EEA1 can interact with themselves, but not with each other, suggesting that EEA1 forms parallel coiled-coil dimers. The ability of the C-terminus of EEA1 to dimerize correlates with its ability to bind to Rab5 and early endosomes, whereas its binding to PtdIns3P is independent of dimerization. These data enable us to propose a model for the quaternary structure of EEA1.
Crozier Formation in Byssochlamys nivea (1982)

Crozier formation in Byssochlamys nivea was studied by means of scanning electron microscopy (SEM) and light microscopic techniques. The continuous recording of crozier formation by time lapse cinematography combined with karyological analyses revealed an important deviation from the classical scheme of crozier formation. In B. nivea the divisions of the two nuclei during crozier formation are not simultaneous (“conjugate”). First, the nucleus in the crook region divides followed by septum formation, and then the nucleus in the basal region undergoes nuclear division followed by septum formation. The three-dimensional arrangement of crozier chains was analyzed by SEM. Subsequent croziers are turned against each other at an angle of 120°. There are two modes of crozier chain branching: formation of one crozier, each, from the penultimate cell and from the fused terminal cell, and simultaneous formation of the two croziers from the penultimate cell.
Realización de arquitecturas de código intermedio mediante un proceso de transcodificación concurrente con la ejecución (1987)

Está generalmente admitida la necesidad de soportar arquitecturalmente a los lenguajes de alto nivel. Con algunas excepciones, hasta hace poco se ha puesto un énfasis especial en el soporte en tiempo de ejecución, mientras que la traducción ha quedado relegada a un segundo plano. Reconociendo explícitamente la importancia de que las arquitecturas de computadores ofrezcan una elevada eficiencia en la ejecución de programas escritos en alto nivel, parece también necesario incorporar facilidades que permitan reducir el espacio existente entre los lenguajes de programación y de máquina, conocido como intervalo o gap semántico. Desde hace bastantes años se vienen realizando muchos esfuerzos para disminuir el gap semántico, con frecuencia mediante propuestas que conducen a un considerable aumento de la complejidad de los procesadores [Patterson, 80], [Bernhard, 81], [Gupta, 83], [Meneses, 87], Actualmente se reconoce que su existencia es consecuencia de la arquitectura von Neumann con la que se realizan la mayor parte de los computadores tradicionales y cuya renovación aparece cada dia más necesaria [Treleaven, 82]. Desafortunadamente, existen diversos problemas para la introducción de conceptos arquitecturales radicalmente diferentes de los convencionales. Por un lado está la eficiencia y flexibilidad con la que la arquitectura von Neumann trata y se adapta a los problemas, progresivamente mayor conforme asimila nuevos avances de la tecnología VLSI. Por otra parte, esta arquitectura se ha venido asentando a lo largo de casi cinco décadas de realización de computadores electrónicos, existiendo profundos conocimientos y experiencia sobre la misma, asi como unas cuantiosas inversiones imposibles de ignorar. De este modo resulta que notables aportaciones en este campo quedan relegadas a experimentos más o menos académicos que encuentran difícil su aceptación general por un gran número de usuarios [Yau, 77], [Treleaven, 84], [Azaria, 87]. En cambio, parece mucho más viable una transición progresiva hacia nuevas arquitecturas, aceptando como punto de partida, la amplia experiencia existente respecto a la von Neumann. Al menos esta via debe ser investigada en tanto que existan alternativas que permitan una reducción del gap semántico, una mayor flexibilidad, mejore la eficiencia y otras características positivas, manteniendo al mismo tiempo y dentro de lo posible, la experiencia, realizaciones e incluso buena parte de las inversiones existentes con la arquitectura clásica a nivel de hardware y de software. En esta linea, el trabajo que se expone en esta memoria se enmarca entre los intentos de renovación arquitectural de los sistemas informáticos, aceptando como base la arquitectura von Neumann con la que se realizan la inmensa mayoría de los procesadores actuales.
ChemInform Abstract: Mild Electrophilic Trifluoromethylthiolation of Ketones with Trifluoromethanesulfanamide. (2015)

Abstract The trifluoromethylthiolation of ketones (I), (IV), and (VI) proceeds readily in the presence of acetyl chloride to afford mono‐trifluoromethylthiolated products (III), (V), and (VII).
Examining Cuphea as a Potential Host for Western Corn Rootworm (Coleoptera: Chrysomelidae): Larval Development (2008)

In previous crop rotation research, adult emergence traps placed in plots planted to Cuphea PSR-23 (a selected cross of Cuphea viscosissma Jacq. and Cuphea lanceolata Ait.) caught high numbers of adult western corn rootworms, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), suggesting that larvae may have completed development on this broadleaf plant. Because of this observation, a series of greenhouse and field experiments were conducted to test the hypothesis that Cuphea could serve as a host for larval development. Greenhouse-grown plants infested with neonates of a colonized nondiapausing strain of the beetle showed no survival of larvae on Cuphea, although larvae did survive on the positive control (corn, Zea mays L.) and negative control [sorghum, Sorghum bicolor (L.) Moench] plants. Soil samples collected 20 June, 7 July, and 29 July 2005 from field plots planted to Cuphea did not contain rootworm larvae compared with means of 1.28, 0.22, and 0.00 rootworms kg−1 soil, respectively, for samples collected from plots planted to corn. Emergence traps captured a peak of eight beetles trap−1 day−1 from corn plots on 8 July compared with a peak of 0.5 beetle trap−1 day−1 on 4 August from Cuphea plots. Even though a few adult beetles were again captured in the emergence traps placed in the Cuphea plots, it is not thought to be the result of successful larval development on Cuphea roots. All the direct evidence reported here supports the conventional belief that rootworm larvae do not survive on broadleaf plants, including Cuphea.
Calcium phosphate biomaterials for the local delivery of bisphosphonate: Influence of chemical association on the in vitro activity (2007)

1076-3279
IL-12Rβ2 Is Essential for the Development of Experimental Cerebral Malaria (2012)

Abstract A Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The role of pro-Th1 IL-12 in malaria is complex and controversial. In this study, we addressed the role of IL-12Rβ2 in ECM development. C57BL/6 mice deficient for IL-12Rβ2, IL-12p40, or IL-12p35 were analyzed for ECM development after blood-stage PbA infection in terms of ischemia and blood flow by noninvasive magnetic resonance imaging and angiography, T cell recruitment, and gene expression. Without IL-12Rβ2, no neurologic sign of ECM developed upon PbA infection. Although wild-type mice developed distinct brain microvascular pathology, ECM-resistant, IL-12Rβ2–deficient mice showed unaltered cerebral microcirculation and the absence of ischemia after PbA infection. In contrast, mice deficient for IL-12p40 or IL-12p35 were sensitive to ECM development. The resistance of IL-12Rβ2–deficient mice to ECM correlated with reduced recruitment of activated T cells and impaired overexpression of lymphotoxin-α, TNF-α, and IFN-γ in the brain after PbA infection. Therefore, IL-12Rβ2 signaling is essential for ECM development but independent from IL-12p40 and IL-12p35. We document a novel link between IL-12Rβ2 and lymphotoxin-α, TNF-α, and IFN-γ expression, key cytokines for ECM pathogenesis.
Optical molecular imaging of lymph nodes using a targeted vascular contrast agent (2005)

We develop a highly specific antibody-dye conjugate for optical imaging of peripheral lymph nodes. The contrast agent consists of the monoclonal antibody recognizing endothelial ligands for the lymphocyte homing receptor L-selectin, MECA-79, and a near-infrared (near-IR) fluorescent indotricarbocyanine dye. The targeting and biodistribution behavior of MECA-79 is studied after radio-iodination and intravenous injection into mice demonstrating specific uptake in lymph nodes and accumulation in high endothelial venules (HEV). After conjugation of MECA-79 with indotricarbocyanine dye, the fluorescence imaging properties of the MECA-79 dye conjugate are examined by intravenous injection in nude mice and laser-induced fluorescence whole-body imaging in vivo. The MECA-79 antibody-dye conjugate accumulates in peripheral lymph nodes, whereas an isotype antibody-dye conjugate does not. Specific lymph node near-IR fluorescent signals become detectable within minutes after injection, and stable imaging persists for more than 24 h. The results demonstrate that vascular targeting of endothelial expression of glyocproteins is feasible to visualize the accumulation of near-IR fluorescent MECA-79 in lymph nodes, making this technology potentially useful to characterize processes of inflammation.
EDGE data receiver design (2003)

Data receiver design is one of the most challenging tasks in EDGE terminal implementation. We outline critical design considerations for data receiver and describe their impact on the receiver performance. Sensitivity of the design to specific receiver parameters is illustrated, showing that overall solution requires complex balance between channel estimation, synchronization, equalization and soft bit information for channel decoding.
Palladium-Catalyzed Oxalyl Amide Directed Silylation and Germanylation of Amine Derivatives (2015)

Palladium-catalyzed direct ortho-silylation of oxalyl amide-protected phenylmethanamine and phenethylamine with commercially available disilanes is reported. Germanylation products were also produced under the same reaction conditions. This protocol tolerated oxalyl amide-protected aliphatic amines, which gave γ-C-H silylation products.
Pharmacokinetics of ciclopirox prodrug, a novel agent for the treatment of bladder cancer, in animals and humans. (2019)

e14705 Background: Ciclopirox Prodrug (CPX-POM) is a novel anticancer agent currently being evaluated in patients with advanced solid tumors participating in a First-in-Human, Phase 1 safety, dose tolerance, pharmacokinetics (PK) and pharmacodynamics trial at four US sites. In vitro and in vivo preclinical proof of principle was established in high grade human urothelial cancer cell lines as well as a mouse model of bladder cancer.Methods: A series of in vivo PK studies were conducted in mice, rats and dogs to characterize the absolute bioavailability of CPX following intravenous (IV), subcutaneous (SC) and oral administration of CPX-POM. The single dose and steady-state plasma and urine pharmacokinetics of CPX-POM are also currently being characterized in patients participating in the ongoing Phase 1 trial. Plasma and urine concentrations of the prodrug and metabolites were determined by LC-MS/MS validated in each specie and matrix. Non-parametric pharmacokinetic parameters were generated from resultant plasma and urine drug and metabolite concentration-time data. Results: CPX-POM is rapidly and completely metabolized to CPX in blood via circulating phosphatases in animals and humans. CPX is completely bioavailable following IV CPX-POM administration in mice, rats and dogs. CPX and its major inactive glucuronide metabolite (CPX-G) are extensively eliminated in urine in all animal species. SC administration of CPX-POM demonstrated excellent bioavailability in rats and dogs. Following IV administration of 30-900 mg/m 2 CPX-POM to patients, the apparent elimination half-life of CPX ranged from 2 to 8 hours, CPX systemic exposure was dose-proportional and time-independent in cancer patients, and a major portion of the dose was eliminated as CPX-G. Conclusions: IV CPX-POM achieves plasma and urine CPX exposures that exceed in vitro IC50 values several-fold at well tolerated doses in animals and humans. CPX pharmacokinetics observed in animals were predictive of human systemic clearance based on allometric scaling. Clinical trial information: NCT03348514.
Religion and Evolution Reconciled (2003)

The harmony of science and religion is a central teaching of the Bahá’í Faith that has important implications for the development of society and the emergence of a global civilization. Science and religion, “the two most potent forces in human life,” have often been at odds, most notably over evolution and the origins of man. ‘Abdu’l-Bahá has commented at length on evolution and man’s origins, providing the most extensive exploration of the harmony of science and religion in the Bahá’í canon. We systematically survey ‘Abdu’l-Bahá’s teachings on evolution and show that He reconciles two viewpoints—evolution and divine creation—that other thinkers have deemed irremediably in conflict.
Autonomous Perforating System for Multizone Completions (2011)

Abstract Autonomous downhole tools offer a range of advantages over conventional tools controlled manually via umbilicals. For instance, perforating guns or bridge plugs could be dropped or pumped downhole without the use of wireline (slick or electric line), coiled tubing or tractors. Because umbilical intervention is no longer required, the tools may automatically perform an action (e.g., perforate a desired interval) with substantial cost reduction and enhanced safety. The elimination of wireline lubricators, lifting equipment, wires, additional personnel and vehicles minimizes the potential for accidents in this already confined space. This is particularly important during hydraulic fracturing operations where this method may enable faster pumping rates and increased fracture volumes during daylight hours. Use of this technology will also reduce air emissions from support equipment that would no longer be required. This paper describes an autonomous perforating tool currently being developed by ExxonMobil Upstream Research Company. This patent pending technology is based on using a self-destructing disposable perforating tool which is run without a wireline. To accomplish this objective, the custom designed tool has three frangible components: 1) a logging device; 2) an on-board navigation system; and 3) friable perforating guns. The on-board navigation system reads the log signals and performs real-time processing of the depth data. Upon matching of the desired depth, the system issues a firing command to the friable perforating gun assembly. The latter simultaneously initiates the self-destruction of the tool. Thus, the tool is completely destroyed after perforating and the remaining debris fall to the bottom of the hole, where they could be left, flowed back to surface or removed during cleanup prior to tubing installation. The volume of debris is small and does not require drilling additional rat hole. The delivery of the tool is achieved by either gravity free-falling in low-angle wells or by pumping it downhole during hydraulic fracturing or any other pumping operation in high-angle or horizontal wells. An important part of the overall design is the safety system built into the tool to make the system as safe as, or safer than currently used perforating practices.
How to cope with anomalies in parallel approximate branch-and-bound algorithms (1984)

Abstract: A genera! technique for solving a wide variety of search problems is the branch-and-bound (B&amp;amp;B) algorithm. We have adapted and extended B&amp;amp;B algorithms for parallel processing. Anomalies owing to parallelism may occur.-In this paper sufficient conditions to guarantee that parallelism will not degrade the performance are presented. Necessary condi-tions for allowi &amp;amp; parallelism to have a speedup greater than the number of processors are also shown. Anomalies are found to occur infrequently when optima! solutions are sought; how-ever, they are frequent in- approximate B&amp;amp;B algorithms. Theoretical analysis and simulations show that a best-first search is robust for parallel processing. 1.
Workload based optimization of probe-based storage (2002)

The performance gap between microprocessors and secondary storage is still a limitation in today's systems. Academia and industry are developing new technologies to overcome this gap, such as improved read-write head technology and higher storage densities. One promising new technology is probe-based storage[1]. Characteristics of probe-based storage include small size, high density, high parallelism, low power consumption, and rectilinear motion. We have created a probe-based storage simulation model, configurable to different design points, and identify its sensitivity to various parameters.
Conceptual design of a helicon ion source for high-current dc accelerators (1998)

Characteristics of helicon plasmas are examined as a candidate for accelerator ion sources. Helicon plasmas have much higher density with very high power efficiency in a relatively lower magnetic field than electron cyclotron resonance plasmas do. High electron density and high electron temperature are beneficial to extract high ion current density. Low magnetic field favors for low-emittance accelerators. Taking advantage of placing antenna outside of the plasma chamber, source contamination can be kept low enough to maintain a stable operation for longer periods. Based on these characteristics, new designs of high current ion sources using helicon waves are proposed for accelerator applications for the first time.
Microbial Community Succession is Associated With Corn Straw Degradation in Microbial Consortium M44 During Subculture (2021)

Abstract To systematically analyze the succession of functional microbiota that plays an important role during culture of microbial consortia M44 and its relationship with straw degradation characteristics, we determined the straw degradation ratio and activities of cellulose, hemicellulose, lignin enzyme, and VFA content of M44 in different culture periods. We also used 16S rRNA gene sequencing to analyze the change in microbial community structure in M44 and explore the differences in microbial composition in the original sample. The results showed that at 15 ℃ for 21 days, the straw degradation rate, endoglucanase activity, and filter paper enzyme activity of M44 generally decreased with increasing culture age, reaching their highest values at F1. The activities of xylanase, laccase, and lignin peroxidase, as well as VFA content, were the highest at F5, showing a single-peak curve change with first an increase and then decrease. At the phylum level, Proteobacteria, Bacteroidetes, and Firmicutes were dominant in the original samples and in different culture stages. At the genus level, Devosia and Bacillus were dominant in the original sample. During subculture, the dominant bacteria in the first generation (F1) were Pseudomonas , Flavobacterium , Brevundimonas , Achromobacter , Chryseobacterium , and Devosia . The dominant genera in the last generation (F11) were Trichococcus , Acinetobacter , Dyssgonomonas , and Rhizobium . In conclusion, we identified changes in microbial community structure occurring in M44 during subculture, as well as similarities and differences in microbial communities from the original sample.
NASA Glenn’s Contributions to Aircraft Engine Noise Research (2022)

This presentation reviews engine noise research conducted at the NASA Glenn Research Center over the past 70 years. This report includes a historical perspective of the Center and the facilities used to conduct the research. Major noise research programs are highlighted to show their impact on industry and on the development of aircraft noise reduction technology. Noise reduction trends are discussed, and future aircraft concepts are presented. Since the 1960s, research results show that the average perceived noise level has been reduced by about 20 decibels (dB). Studies also show that, depending on the size of the airport, the aircraft fleet mix, and the actual growth in air travel, another 15 to 17 dB reduction will be required to achieve NASAs long-term goal of providing technologies to limit objectionable noise to the boundaries of an average airport.
Transverse modes of gain-guided coupled-stripe lasers: External cavity control of the emitter spacing (1985)

By means of an external grating cavity, the dispersion relation of the transverse modes of gain-guided coupled-stripe laser diodes is determined. The parabolic relation obtained indicates (despite the stripes) a relatively flat gain profile similar to a broad area laser. Accordingly, higher order transverse modes are possible and are demonstrated with near and far fields exhibiting one and two emitters per stripe.