gebhart/patrepeval huggingface dataset:
Numerical Study of a Solar Chimney Power Plant (2014)

The aim of this study is to present a numerical analysis on the performance of a solar chimney power plant using steady state Navier-Stokes and energy equations in cylindrical coordinate system. The fluid flow inside the chimney is assumed to be turbulent and simulated with the k-ε turbulent model, using the FLUENT software package. Numerical simulations were performed using the Spanish prototype as reference. The computed results are in good agreement with experimental measurements of Manzanares power plant. Besides, a theoretical model was proposed taking into account the kinetic energy difference within the solar collector. The effects of the main geometrical parameters of the collector and the solar radiation intensity on the air mass flow rate and the temperature rise in the collector have been investigated. The fluid and ground temperature distributions were also presented and analyzed.
ChemInform Abstract: LABORATORY EXPLOSION (1979)

Abstract Diethylaminoschwefeltrifluorid (I) zersetzt sich bei Temperaturen oberhalb 95°C explosionsartig.
Tunable Lloyd-Mirror Interferometer for Large-Area Nanopatterning (2009)

This paper reports on a new Lloyd-mirror interference lithography system whose mirror angle is variable with respect to the substrate. We demonstrate that this tunable Lloyd-mirror interferometer significantly increases the nanopatterning area with greater controllability compared to a conventional fixed-angle system for pattern periodicity over 500 nm. The new configuration capable of the independent control of mirror angle will enhance the advantages of Lloyd-mirror interferometer for large-area nanopatterning with more flexibility.
Polypropylene based polymer blends: Fields of application and new trends (1984)

Abstract The new industrial strategy in the polymer field requires the transformation of plastic “commodities” into “specialties”. From this point of view, polypropylene (PP) plays an important role both for its intrinsic properties such as high melting temperature, low density, high chemical inertness and for its capability to be produced with different morphological and molecular structures, to be modified with the addition of other polymers or mineral fillers and to be grafted with functional groups. The present range of special and reinforced polypropylene grades includes: elastomer‐modified PP, elastomer‐modified filled PP, glass fiber‐reinforced PP, filled PP, esthetic filled PP, flame‐retardant PP, and thermoplastic elastomers. New trends for significantly improving this family of polymers involve impact resistance, processability, durability, dimensional stability, elasticity, and surface properties. A positive answer to this complex emerging demand will put, as indicated, in this work, “special and reinforced polypropylene grades” in a position to successfully compete with technopolymers in some important, rapidly growing application sectors.
Activation of K+channels: an essential pathway in programmed cell death (2004)

Cell apoptosis and proliferation are two counterparts in sharing the responsibility for maintaining normal tissue homeostasis. In recent years, the process of the programmed cell death has gained much interest because of its influence on malignant cell growth and other pathological states. Apoptosis is characterized by a distinct series of morphological and biochemical changes that result in cell shrinkage, DNA breakdown, and, ultimately, phagocytic death. Diverse external and internal stimuli trigger apoptosis, and enhanced K+ efflux has been shown to be an essential mediator of not only early apoptotic cell shrinkage, but also of downstream caspase activation and DNA fragmentation. The goal of this review is to discuss the role(s) played by K+ transport or flux across the plasma membrane in the regulation of the apoptotic volume decrease and apoptosis. Attention has also been paid to the role of inner mitochondrial membrane ion transport in the regulation of mitochondrial permeability and apoptosis. We provide specific examples of how deregulation of the apoptotic process contributes to pulmonary arterial medial hypertrophy, a major pathological feature in patients with pulmonary arterial hypertension. Finally, we discuss the targeting of K+ channels as a potential therapeutic tool in modulating apoptosis to maintain the balance between cell proliferation and cell death that is essential to the normal development and function of an organism.
Speaker Independent Phoneme Recognition Based on Fisher Weight Map (2008)

We have already proposed a new feature extraction method based on higher-order local auto-correlation and Fisher weight map (FWM) at Interspeech2006. This paper shows effectiveness of the proposed FWM in speaker dependent and speaker independent phoneme recognition. Widely used MFCC (Mel-frequency cepstrum coefficient) features lack temporal dynamics. To solve this problem, local auto-correlation features are computed and accumulated by weighting high scores on the discriminative areas. This score map is called Fisher weight map. From the speaker dependent phoneme recognition, the proposed FWM showed 79.5% recognition rate, by 5.0 points higher than the result by MFCC. Furhermore by combing FWM with MFCC and DeltaMFCC, the recognition rate improved to 88.3%. In the speaker independent phoneme recognition, it showed 84.2% recognition rate, by 11.0 points higher than the result by MFCC. By combining FWM with MFCC and DeltaMFCC, the reecognition rate improved to 89.0%.
In vivo response of microfabricated glucose sensors to glycemia changes in normal rats. (1989)

A planar glucose sensor based on an amperometric detection of H2O2 is presented. The transducer part which is a planar three-electrode cell consisting of two Pt-electrodes and one Ag/AgCl-thin film electrode is realized using microelectronic technology. The overall dimensions are 0.8 mm x 3 mm x 0.38 mm and the working electrode area is 0.1 mm2. GOD is immobilized using glutaraldehyde as a cross-linking agent and bovine serum albumin as a carrier protein. The resulting membrane has a typical thickness of 25 microns. Also, an outer polyurethane membrane is dip-coated all around the tip of the electrode. The influence of pO2 on the sensor response as well as the sensor temperature coefficient, sensitivity and linear range have been investigated. The sensor has been tested in vivo in a subcutaneous tissue of anaesthetised rats. During experiments, blood sampling allows to measure changes in venous plasma glucose using a Beckman analyzer. The sensor response following hyperglycaemic clamps as well as intravenous glucose loads is discussed.
Joint associations of physical activity and screen time with overweight among japanese adults (2011)

Both insufficient PA and prolonged ST contribute to overweight and obesity among Japanese adults. Public health initiatives addressing obesity in Japan need to consider both promoting PA and reducing ST, especially in men.
Dynamic Ordering of Firewall Rules Using a Novel Swapping Window-based Paradigm (2016)

Designing and implementing efficient firewall strategies in the age of the Internet of Things (IoT) is far from trivial. This is because, as time proceeds, an increasing number of devices will be connected, accessed and controlled on the Internet. Additionally, an ever-increasingly amount of sensitive information will be stored on various networks. A sound and efficient firewall strategy will attempt to secure this information, and to manage the large amount of inevitable network traffic that these devices create. The goal of this paper is to propose a framework for designing optimized firewalls for the IoT.
Digital competence across boundaries - beyond a common Nordic model of the digitalisation of K-12 schools? (2021)

This paper explores policy related to digital competence and the digitalisation of Nordic K-12 schools. Anchored in some key transnational policies on digital competence, it describes some current Nordic movements in the national policies of Denmark, Finland, Norway and Sweden. The concept of boundary objects is used as an analytical lens, for understanding digital competence as a plastic and temporal concept that can be used to discuss the multi-dimensional translation of this concept in these Nordic countries. The paper ends with a discussion of the potential to view digital competence as a unifying boundary object that, with its plasticity, temporality and n-dimensionality, can show signs of common Nordic efforts in the K-12 school policy.
Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. (1980)

3T3-L1 preadipocytes, cloned from 3T3 mouse embryo fibroblasts, differentiate in monolayer culture into cells with morphological and biochemical characteristics of adipocytes. Deposition of cytoplasmic triglyceride is associated with an increased lipogenic rate and a coordinate rise in the activities of many lipogenic enzymes (Mackall, J.C., Student, A.K., Polakis, S.E., and Lane, M.D. (1976) J. Biol. Chem. 251, 6462-6464). During differentiation induced by a 48-h treatment of postconfluent cells with methylisobutylxanthine, dexamethasone, and insulin, fatty acid synthetase activity increased to a level 19.5-fold higher than that of undifferentiated 3T3-L1 cells or nondifferentiating 3T3-C2 cells. The rate of [3H]leucine incorporation into immunoadsorbable fatty acid synthetase rose to a maximum and then declined to a new level 12.5-fold higher in differentiated than in undifferentiated 3T3-L1 cells. The kinetics of the changing [3H]leucine incorporation rate was reflected in the kinetics of the rise in fatty acid synthetase activity. The rate of degradation of fatty acid synthetase, determined by pulse-chase experiments, was unaffected by differentiation, the t1/2 remaining constant at 1.4 days. It is concluded that the higher level of fatty acid synthetase activity in differentiated 3T3-L1 cells can be attributed entirely to an increased rate of enzyme synthesis. The rate of total cellular protein synthesis also increases early early in differentiation, lending support to a model in which the synthesis of a large number of "differentiated proteins" is coordinately induced.
Abstract A276: Phase 1 multicenter, open label, dose-escalation study of LEE011, an oral inhibitor of cyclin-dependent kinase 4/6, in patients with advanced solid tumors or lymphomas. (2013)

Abstract Background: LEE011 is an oral small molecule inhibitor with highly specific nanomolar inhibitory activity against CDK4/cyclinD1 and CDK6/cylinD3 complexes. Preclinical studies with LEE011 have demonstrated robust anti-tumor activity in several tumor models with functional retinoblastoma protein (pRb). Methods: The primary objective this phase 1 dose escalation study was to determine the maximum tolerated dose (MTD) based on cycle 1 dose-limiting toxicities (DLTs) and establish the recommended dose for expansion (RDE) of LEE011 in patients (pts) with pRb-positive advanced solid tumors or lymphomas. Using a Bayesian logistic regression model with overdose control principle, escalating doses of LEE011 were administered daily for 21 days of 28-day cycles. Following MTD determination, a continuous dosing schedule was also evaluated. Evaluation of safety and pharmacokinetics (PK) from all pts contributed to defining the RDE. Results: As of June 28, 2013, a total of 70 pts were treated in the escalation phase at doses from 50-1200 mg. DLTs are described in the table. MTD was defined at 900 mg on a 21 of 28-day dosing schedule. Additional patients were treated at 750 mg and 600 mg on the current schedule and at 600 mg on a continuous schedule to define the RDE and sustain optimal long-term dosing. Following review of PK and safety data, including AEs observed beyond cycle 1, the planned RDE is 600 mg for 21 days of a 28-day treatment cycle. Common adverse events (AEs) were gastrointestinal (nausea 40%, diarrhea 30%) and hematologic (anemia 43%, neutropenia 40%); the majority of AEs were grades 1/2 and reversible. Asymptomatic QTc prolongation was observed at the higher doses. LEE011 is absorbed orally with Tmax ≈ 4 hours and effective t1/2 ≈24 hours. Dose-dependent increases in exposure were observed. Preliminary evidence of activity was observed including stable disease for ≥ 6 cycles in 10/70 pts (14%) and 1 confirmed partial response in a pt with ER-positive breast cancer. Preliminary tumor pharmacodynamic data shows evidence of modulation at doses of 600 mg and above. Conclusions: LEE011, a highly selective inhibitor of CDK4/6, exhibited an acceptable safety profile, dose dependent PK, and preliminary clinical activity. Enrollment will continue in the expansion phase. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A276. Citation Format: Jeffrey R. Infante, Geoffrey I. Shapiro, Petronella O. Witteveen, John F. Gerecitano, Vincent Ribrag, Rashmi Chugh, Abhijit Chakraborty, Alessandro Matano, Xumei Zhao, Sudha Parasuraman, Philippe A. Cassier. Phase 1 multicenter, open label, dose-escalation study of LEE011, an oral inhibitor of cyclin-dependent kinase 4/6, in patients with advanced solid tumors or lymphomas. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A276.
Control Design for an Emulator of Mechatronic Powertrain Dynamics: A Case Study (2020)

Abstract This paper discusses a detailed design procedure of a linear torque controller for an in-house developed lab-scale powertrain emulator. This set-up was developed for the validation of new developments in virtual torque sensing, and thus requires decent torque tracking performance in order to simulate real drivetrain dynamics sufficiently accurate. Standard proportional-integral (PI) controllers are not able to effectively compensate for potential flexible modes of the set-up, and an H∞ control approach is proposed. The different design steps then comprise experiment design, identification, feedback controller design using H∞ loop shaping, and inverse-based feedforward controller design. Experimental results demonstrate the obtained torque tracking performance.
Exposing unsaturated Cu 1 -O 2 sites in nanoscale Cu-MOF for efficient electrocatalytic hydrogen evolution (2021)

Conductive metal-organic framework (MOF) materials have been recently considered as effective electrocatalysts. However, they usually suffer from two major drawbacks, poor electrochemical stability and low electrocatalytic activity in bulk form. Here, we have developed a rational strategy to fabricate a promising electrocatalyst composed of a nanoscale conductive copper-based MOF (Cu-MOF) layer fully supported over synergetic iron hydr(oxy)oxide [Fe(OH) <i><sub>x</sub></i> ] nanoboxes. Owing to the highly exposed active centers, enhanced charge transfer, and robust hollow nanostructure, the obtained Fe(OH) <i><sub>x</sub></i> @Cu-MOF nanoboxes exhibit superior activity and stability for the electrocatalytic hydrogen evolution reaction (HER). Specifically, it needs an overpotential of 112 mV to reach a current density of 10 mA cm<sup>-2</sup> with a small Tafel slope of 76 mV dec<sup>-1</sup> X-ray absorption fine structure spectroscopy combined with density functional theory calculations unravels that the highly exposed coordinatively unsaturated Cu<sub>1</sub>-O<sub>2</sub> centers could effectively accelerate the formation of key *H intermediates toward fast HER kinetics.
XAFS Measurements of Rb-O Bonds in Ambient and Supercritical Water (1997)

XAFS measurements and analyses of Rb+ ions in 0.5 molal RbBr at ambient and several supercritical (P > Pc = 220 bar, T < Tc = 374°C) conditions are presented. The first coordination shell of Rb+ ion is seen to be dominated by oxygen from nearby water molecules. Upon going from ambient to supercritical conditions, the Rb-O coordination number decreases significantly, and the Rb-O distance decreases by ~ 0.10 Å relative to the ambient Rb-O distance (~ 2.93 Å). Although ion pairing has been predicted for supercritical conditions (due in part to a substantial decrease of the dielectric constant at the critical point), and has been observed with XAFS in other aqueous solutions, we see no direct evidence of pairing of Br- with Rb+ in our measurements.
Folate, Homocysteine and the Cardiac Neural Crest (2013)

Congenital heart defects (CHD) are the most common congenital defects worldwide, and perigestational folate supplementation (PFS) is the most effective large-scale intervention to date for reducing CHD. This review is based upon the following premises: that the majority of CHD result from disruption of development of the cardiac neural crest (CNC); and that the CNC is highly responsive to folate and homocysteine. The following roles of folate are discussed in relation to CNC development: one-carbon metabolism in support of mitosis and gene methylation; and gene regulation via direct activity of the folate receptor. The following roles of hyperhomocysteinemia are discussed in the same context: increased oxidative stress; disruption of gene methylation; homocysteinylation of key proteins; and NMDA receptor binding. It is proposed that well-focused advances in folate-CNC research could lead to development of strategies, in addition to PFS, to facilitate normal CNC and heart development, and thereby further reduce CHD.
Freely available artificial intelligence for pelvic lymph node metastases in PSMA PET-CT that performs on par with nuclear medicine physicians (2022)

This study shows that AI can obtain a sensitivity on par with that of physicians with a reasonable number of false positives. The difficulty in achieving high inter-observer sensitivity emphasizes the need for automated methods. On the road to qualifying AI tools for clinical use, independent validation is critical and allows performance to be assessed in studies from different hospitals. Therefore, we have made our AI tool freely available to other researchers.
The Studies of Thiosulfate and Lead-induced Stress Corrosion Cracking of Alloy 800 (2011)

Scratch test and scanning electrochemical microscopy (SECM) were applied to study the effects of thiosulfate on stress corrosion cracking (SCC) of Alloy 800 in simulated crevice solutions. The results showed that thiosulfate cathodically shifted the pitting potential of Alloy 800 significantly and the pitting morphology on the electrode surface was also different from that formed in the absence of thiosulfate. The synergistic effect between thiosulfate and stress was also observed, which was mainly promoting enhanced anodic dissolution at active sites. In the lead-induced stress corrosion crackings (PbSCC) work, the crack propagation rate (CPR) of Alloy 800 double cantilever specimen were estimated in neutral crevice chemistries solutions at 300 degree Celsius. The PbSCCof alloy 800 at high temperature were investigated by comparing the CPR rate of Pb-contaminated and Pb-free conditions. A repetitive behavior of crack advance was observed from the measurement. This observation is consistent with the film rupture model.
A simple fast acting gas selection valve (1984)

A gas selection valve suitable for use with highly adsorptive gases has been designed for studies of gas effects on semiconductor gas sensors. It can provide step changes in gas concentrations at very low levels (<1 PPM) and is suitable for use in automated experiments involving up to four different gases or gas mixtures.
OPTIMUM DESIGN OF A TUNED-INERTER-HYSTERETIC-DAMPER (TIHD) FOR BUILDING STRUCTURES SUBJECT TO EARTHQUAKE BASE EXCITATIONS (2020)

OPTIMUM DESIGN OF A TUNED-INERTER-HYSTERETIC-DAMPER (TIHD) FOR BUILDING STRUCTURES SUBJECT TO EARTHQUAKE BASE EXCITATIONS - XI International Conference on Structural Dynamics - 23-26 November 2020, Athens, Greece
Mortgage Terminations, Heterogeneity and the Exercise of Mortgage Options (2000)

As applied to the behavior of homeowners with mortgages, option theory predicts that mortgage prepayment or default will be exercised if the call or put option is ‘in the money’ by some specific amount. Our analysis: tests the extent to which the option approach can explain default and prepayment behavior; evaluates the practical importance of modeling both options simultaneously; and models the unobserved heterogeneity of borrowers in the home mortgage market. The paper presents a unified model of the competing risks of mortgage termination by prepayment and default, considering the two hazards as dependent competing risks that are estimated jointly. It also accounts for the unobserved heterogeneity among borrowers, and estimates the unobserved heterogeneity simultaneously with the parameters and baseline hazards associated with prepayment and default functions. Our results show that the option model, in its most straightforward version, does a good job of explaining default and prepayment, but it is not enough by itself. The simultaneity of the options is very important empirically in explaining behavior. The results also show that there exists significant heterogeneity among mortgage borrowers. Ignoring this heterogeneity results in serious errors in estimating the prepayment behavior of homeowners.
Longitudinal monitoring of cancer cell subpopulations in monolayers, 3D spheroids, and xenografts using the photoconvertible dye DiR (2019)

A central challenge in cancer biology is the identification, longitudinal tracking, and -omics analysis of specific cells in vivo. To this aim, photoconvertible fluorescent dyes are reporters that are characterized by a set of excitation and emission spectra that can be predictably altered, resulting in a distinct optical signature following irradiation with a specific light source. One such dye, DiR, is an infrared fluorescent membrane probe that can irreversibly undergo such a switch. Here, we demonstrate a method using DiR for the spatiotemporal labeling of specific cells in the context of cancer cell monolayer cultures, 3D tumor spheroids, and in vivo melanoma xenograft models to monitor the proliferation of cellular subpopulations of interest over time. Importantly, the photoconversion process is performed in situ, supporting the pursuit of novel avenues of research in molecular pathology.
The Preparation of Some α-Unsaturated Ethers from 2,2-Dimethoxyalkanes1 (1935)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Some α-Unsaturated Ethers from 2,2-Dimethoxyalkanes1D. B. Killian, G. F. Hennion, and J. A. NieuwlandCite this: J. Am. Chem. Soc. 1935, 57, 3, 544–545Publication Date (Print):March 1, 1935Publication History Published online1 May 2002Published inissue 1 March 1935https://pubs.acs.org/doi/10.1021/ja01306a047https://doi.org/10.1021/ja01306a047research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts