gebhart/patrepeval huggingface dataset:
Multicenter Evaluation of the VERSANT HCV RNA Qualitative Assay for Detection of Hepatitis C Virus RNA (2003)

We report the results of a multicenter evaluation of a new assay for the detection of hepatitis C virus (HCV) RNA in human serum or plasma based on transcription-mediated amplification (HCV TMA). Analysis of combined data obtained from 15 independent sites, including 4 sites in the United States and 11 in Europe, by using preproduction kits showed a limit of detection of 9.8 IU/ml and an overall mean specificity of 97.9%. In addition, assay runs and samples were valid consistently (97.8% of assay runs and 98.0% of specimen results). Of the 15 sites that participated in the multicenter evaluation, 2 subsequently carried out additional performance studies with production kits in support of the assay's registration in France. Comparison of the findings from these two sites during the multicenter evaluation and during the registration studies showed an overall improvement in assay performance. A statistically significant (P < 0.001) improvement was achieved for both specificity and specimen validity in the registration studies, which were 99.4 and 98.1%, respectively. Combined data from the two sites showed a lower limit of detection of approximately 2.4 IU/ml and an improved assay validity of 100%, although the sample size was too small to show statistical significance at the 0.05 level. In summary, the performance characteristics of HCV TMA indicate that this assay is a reliable tool for the detection of HCV RNA in serum or plasma. Improvement in assay performance has been demonstrated with refinement of assay reagents, instrumentation, and operator experience.
Office-Based Balloon Sinus Dilation (2015)

Following office-based BSD, significant improvements in quality of life observed at 24 weeks were maintained 1 year postsurgery. These extended results provide further evidence of office-based BSD as an effective, minimally invasive procedure for appropriately selected patients with CRS.
Parvovirus transmission by blood products – a cause for concern? (2012)

The introduction of dual viral inactivation of clotting factor concentrates has practically eliminated infections by viruses associated with significant pathogenicity over the last 20 years. Despite this, theoretical concerns about transmission of infection have remained, as it is known that currently available viral inactivation methods are unable to eliminate parvovirus B19 or prions from these products. Recently, concern has been raised following the identification of the new parvoviruses, human parvovirus 4 (PARV4) and new genotypes of parvovirus B19, in blood products. Parvoviruses do not cause chronic pathogenicity similar to human immunodeficiency virus or hepatitis C virus, but nevertheless may cause clinical manifestations, especially in immunosuppressed patients. Manufacturers should institute measures, such as minipool polymerase chain reaction testing, to ensure that their products contain no known viruses. So far, human bocavirus, another new genus of parvovirus, has not been detected in fractionated blood products, and unless their presence can be demonstrated, routine testing during manufacture is not essential. Continued surveillance of the patients and of the safety of blood products remains an important ongoing issue.
The Design, Modeling, and Evaluation of the Relax Architectural Framework (2010)

As transistor technology scales ever further, hardware reliability is becoming harder to manage. The effects of soft errors, variability, wear-out, and yield are intensifying to the point where it becomes difficult to harness the benefits of deeper scaling without mechanisms for hardware fault detection and correction. We observe that the combination of emerging applications and emerging many-core architectures makes software recovery a viable and interesting alternative to traditional, hardware-based fault recovery. Emerging applications tend to have few I/O and memory side-effects, which limits the amount of information that needs checkpointing, and they allow discarding individual sub-computations with typically minimal qualitative impact. Software recovery can harness these properties in ways that hardware recovery cannot. Additionally, emerging many-core architectures comprised of many simple, in-order cores pay heavily in terms of power and area for hardware checkpointing resources. Software recovery can be more efficient while it simultaneously simplifies hardware design complexity. &#13;\n&#13;\nIn this paper, we describe Relax, an architectural framework for software recovery of hardware faults. We describe Relax's language, compiler, ISA, and hardware support, develop analytical models to project performance, and evaluate an implementation of the framework on the compute kernels of seven emerging applications. Applying Relax to counter the effects of process variation, we find that Relax can enable a 20% energy efficiency improvement for more than 80% of an application's execution with only minimal source code changes.
A new class of integrated CMOS rectifiers with improved PVT-compensated efficiency (2012)

We review in this paper a new class of integrated CMOS rectifiers with improved PVT-compensated efficiency and propose also a new voltage quadrupler. By utilizing a threshold compensation technique, the presented circuits are able to achieve both high voltage conversion efficiency (VCE) and power conversion efficiency (PCE) with only standard threshold devices at low input amplitudes. Besides, the performance of the rectifiers is selfcompensated over process and temperature, which is achieved by precisely tracking the diode threshold drift with an auxiliary dummy. The rectifiers are implemented in AMS 0.35μm 4M/2P standard CMOS process and the simulated performance is shown at an input frequency of 13.56MHz. For the proposed voltage quadrupler, at 0.8V input amplitude and 2kΩ load resistor, output voltage of 1.52V can be achieved with VCE and PCE of 48% and 49%, respectively. As compared to previously published results, the improvement is up to 358% in VCE and 351% in PCE. Besides, the maximum deviation in its output voltage is as low as 162mV over 100°C temperature span, which outperforms the conventional structure by almost an order of magnitude.
Stereochemistry of cyclohexenone alkylations (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of cyclohexenone alkylationsKundanbhai M. Patel and William ReuschCite this: J. Org. Chem. 1975, 40, 10, 1504–1505Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/jo00898a030https://doi.org/10.1021/jo00898a030research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Frequently subnormal semen profiles of normal volunteers recruited over 17 years (1997)

In order to establish semen profiles for men in the general population, we analysed the semen parameters of 187 men attending the Institute of Reproductive Medicine between 1977 and 1993 as volunteers for clinical studies. If several ejaculates were obtained from the volunteer, only the first ejaculate was used for analysis. More than half of the ejaculates of these healthy men showed at least one abnormal parameter, so that only 46% of the volunteers could be classified as being 'normozoospermic' according to WHO guidelines. Aside from a decrease in the proportion of motile spermatozoa, no change in semen parameters could be detected with advancing age of the volunteers. No negative influence of the presence of a varicocele, the grade of varicocele on a history of maldescended testis on semen parameters was detected. The serum levels of FSH, LH and testosterone showed no significant age-related change over the period of investigation. Follow-up analysis of the fertility on the volunteers revealed a proportion of unwanted barrenness similar to or even lower than that in the general population. The analysis demonstrates that the limits of normality for semen parameters may require redefinition.
A concise specification language for trace monitoring (2015)

In this paper we propose a mechanism called specification for monitoring (SFM) to specify runtime monitoring of programs at a high level, and an abstract API showing how to implement the monitor. SFM enables users to separate the semantic issues related to monitoring and implementation details. This results in compact specifications as the implementation details are delegated to the implementation of the API. We present several specifications to demonstrate that SFM is capable of addressing problems related to runtime fault detection at different levels of abstraction.
Full-Scale Evaluation of Mercury Control by Injecting Activated Carbon Upstream of a Spray Dryer and Fabric Filter on PRB Coal (2004)

One of the most likely air pollution control configurations to be considered for new units burning subbituminous Powder River Basin (PRB) coal will be a spray dryer absorber (SDA) followed by a fabric filter (FF) because it offers cost advantages to meet stringent multi-pollutant control regulations. However, available data indicate that this configuration demonstrates particularly low, native mercury removal and the effectiveness of non-chemically treated activated carbon is limited. ADA-ES, Inc., with support from DOE NETL and industry partners, is conducting a mercury control demonstration using sorbent injection into the SDA-FF at Sunflower Electric’s 360-MW Holcomb Station. This paper will present results from testing including the effect on mercury emissions of 1) blending PRB coal with bituminous coal, 2) injecting alternative sorbents specifically designed to operate in a halogen-deficient flue gas, and 3) injecting chemical additives onto the coal. ADA-ES Pub. No. 04008
Thermal gelation properties of methyl and hydroxypropyl methylcellulose (1979)

Aqueous solutions of methyl and hydroxypropyl methylcellulose are known to gel upon heating. These gels are completely reversible in that they are formed upon heating yet will liquefy upon cooling. The precipitation temperature, gelation temperature, and gel strength of these methylcellulose solutions were determined as a function of molecular weight, degree of methyl and hydroxypropyl substitution, concentration, and presence of additives. The precipitation temperature of these polymer solutions decreases initially with increasing concentration until a critical concentration is reached above which the precipitation temperature is little affected by concentration changes. The incipient gelation temperature decreases linearly with concentration. The strength of these gels is time dependent, increases with increasing molecular weight, decreases with increasing hydroxypropyl substitution, and depends on the nature of additives. Hydrophobe–hydrophobe interaction or micellar interaction is postulated to be the cause of gelation. This thermal gelation property of the polymers is utilized in many end uses including food, pharmaceuticals, ceramics, tobacco, and other industrial applications.
miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells (2021)

Tumor endothelial cells (TECs) reportedly exhibit altered phenotypes. We have demonstrated that TECs acquire drug resistance with the upregulation of P-glycoprotein (P-gp, ABCB1), contrary to traditional assumptions. Furthermore, P-gp expression was higher in TECs of highly metastatic tumors than in those of low metastatic tumors. However, the detailed mechanism of differential P-gp expression in TECs remains unclear. miRNA was identified in highly metastatic tumor extracellular vesicles (EVs) and the roles of miRNA in endothelial cell resistance were analyzed in vitro and in vivo. In the present study, we found that treatment of highly metastatic tumor-conditioned medium induced resistance to 5-fluorouracil (5-FU) with interleukin-6 (IL-6) upregulation in endothelial cells (ECs). Among the soluble factors secreted from highly metastatic tumors, we focused on EVs and determined that miR-1246 was contained at a higher level in highly metastatic tumor EVs than in low metastatic tumor EVs. Furthermore, miR-1246 was transported via the EVs into ECs and induced IL-6 expression. Upregulated IL-6 induced resistance to 5-FU with STAT3 and Akt activation in ECs in an autocrine manner. These results suggested that highly metastatic tumors induce drug resistance in ECs by transporting miR-1246 through EVs.
Perioperative thrombocytopenia in cardiac surgical patients — incidence of heparin-induced thrombocytopenia, morbidities and mortality (2010)

Patients in whom a low platelet count prompted testing for HIT antibodies, had a high mortality (59%), independent of whether heparin-dependent antibodies were present, indicating that a persistently lowered platelet count is a bad prognostic sign after cardiac surgery. Interestingly, the HIPA-positive patients had more central venous and pulmonary embolisms. Patient age, female sex and perioperative sepsis were risk factors for perioperative mortality.
The Growth Behaviors of IMC Layers at Soldered and Diffusion Bonding Sn/Cu Interfaces and the Effects of High Magnetic Field (2008)

The growth behaviors of intermetallic compound (IMC) layers in soldered and diffusion bonding Sn/Cu joints and the effects of magnetic field have been investigated. The results indicate that, without high magnetic field, the growth behaviors of these two IMC layers are similar in the aging except the initial morphologies. However, the morphologies and crystal orientations of these two IMC layers have changed after being aged in high magnetic field.
Graphene Oxide‐Templated Polyaniline Microsheets toward Simultaneous Electrochemical Determination of AA/DA/UA (2011)

Abstract Graphene oxide‐templated polyaniline (GO‐PAN) microsheets were prepared via oxidation polymerization of aniline with graphene oxide (GO) as template. By applying this approach, irregularly shaped GO‐PAN microsheets were obtained which was revealed by scanning electron microscopy (SEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) measurements demonstrated that the resulted GO‐PAN was electroactive and could be further used as electrocatalyst in simultaneous determination of ascorbic acid (AA), dopamine (DA) and together with uric acid (UA).
A 2 GS/s 9-bit Time-Interleaved SAR ADC with Overlapping Conversion Steps (2022)

This paper presents a wideband 8-way time-interleaved (TI) 9-bit successive approximation register (SAR) analog-to-digital converter (ADC) with overlapping conversion steps that improve the speed of operation. The ADC generates its clocks using a synchronous counter based circuit which reduces the SAR delay. A common-mode reference based split capacitor array digital-to-analog converter (DAC) is implemented that achieves high speed and low power consumption. Simulation results are presented for the ADC designed in a 22 nm CMOS process. The TI ADC achieves at least 7.7 ENOB at 2 GS/s and consumes a total of 19.8 mW from 0.8 V supplies, resulting in 47.6 fF/conv-step. The single ADC achieves 8.34 ENOB at 250 MS/s, consuming 1.43 mW in total and 17.7 fF/conv-step.
Design and Implementation of an object-oriented Media Composition Framework (1994)

The goal of the presented project is a general compositonal environment for multimedia with interactive editing facilities. Multimedia presentations are regarded as hierarchical compositions of time objects that define serial or parallel synchronisation of the inserted media objects. Such media composition hierarchies support automatic temporal layout mechanisms and are integrated into an object-oriented application framework that provides direct manipulative interaction on temporal structures through user interface components. In this papaer reusable and extendable components for audio and music processing are presented. Keywords: multimedia composition, audio, 3D graphics, music, time synchronisation, animation, user interface interaction, object-oriented application framework, C++, MET++. 1. Introduction Today computer workstations are used to integrate different media such as text, graphics, audio, and video into one single system in which these media types are handled and manipula...
An Optimized Multi-sensor Fused Object Detection Method for Intelligent Vehicles (2020)

An accurate and efficient environment perception system is crucial for intelligent vehicles. This study proposes an optimized 2D object detection method utilizing multi-sensor fusion to improve the performance of the environment perception system. In the sensor fusion module, a depth completion network is used to predict dense depth map, so both dense and sparse RGB-D images can be obtained. Then, an efficient object detection baseline is optimized for intelligent vehicles. This method is verified by KITTI 2D object detection dataset. The experimental results show that the proposed method can be more accurate than many latest methods on KITTI leaderboard. Meanwhile, this method consumes less inference time and shows its high efficiency.
Fusion of face and speech data for person identity verification (1999)

Biometric person identity authentication is gaining more and more attention. The authentication task performed by an expert is a binary classification problem: reject or accept identity claim. Combining experts, each based on a different modality (speech, face, fingerprint, etc.), increases the performance and robustness of identity authentication systems. In this context, a key issue is the fusion of the different experts for taking a final decision (i.e., accept or reject identity claim). We propose to evaluate different binary classification schemes (support vector machine, multilayer perceptron, C4.5 decision tree, Fisher's linear discriminant, Bayesian classifier) to carry on the fusion. The experimental results show that support vector machines and Bayesian classifier achieve almost the same performances, and both outperform the other evaluated classifiers.
Annotating floor plans using deformable polygons (1993)

The ability to recognize regions in a bitmap image has applications in various areas, from document recognition of scanned building floor plans to processing of scanned forms. We consider the use of deformable polygons for delineating partially or fully bounded regions of a scanned bitmap that depicts a building floor plan. We discuss a semi-automated interactive system, in which a user positions a seed polygon in an area of interest in the image. The computer then expands and deforms the polygon in an attempt to minimize an energy function that is defined so that configurations with minimum energy tend to match the subjective boundaries of regions in the image. When the deformation process is completed, the user may edit the deformed polygon to make it conform more closely to the desired region. In contrast to area-filling techniques for delineating areal regions of images, our approach works robustly for partially bounded regions. Keywords: 2-D graphics, drawing software, region fin...
Poria Luteoalba and Some Related Species in North America (1966)

Poria luteoalaba (Karst.) Sacc, P. eupora Karst., and P. rixosa Karst. have been generally considered to be closely related because of similarity in basidiocarp morphology. One other closely related species, P. radula Pers. ex Fr., occurs in North America, but cultures of this species have not been obtained. Bondarzew and Singer (9) have placed P. eupora, P. rixosa, and P. radula in the genus Chaetoporus Karst. em. Bond., which is described as lacking clamp connections. In 1953, Bon? darzew (8) proposed a new genus, Chaetoporellus, which he described as similar to Chaetoporus but having clamp connections and in which he placed P. luteoalba. Christiansen (12) proposed the new combination Chaetoporus luteoalbus (Karst.) Christiansen. Domanski (16) includes these three species in the genus Chaetoporus but considers P. luteoalba to be a synonym of C. variecolor (Karst.) Parm. (basionym: Physisporus variecolor Karst., in Thuem., Mycotheca Univ., Cent. XIX, No. 1803. 1881). Our studies of these species show a very similar dimitic hyphal system in all three, with nodose-septate generative hyphae and aseptate skeletal hyphae readily discernible. Other characters shared by these three species are the thick-walled, often incrusted hymenial cystidia, and an associated white rot. Other species that have been placed in Chaetoporus [i.e., Poria ambigua Bres., P. corticola (Fr.) Cke., P. pearsonii Pilat, and P. subacida (Pk.) Sacc] do not show close relationship to the three species treated here, having in com? mon only the cystidia, but difrering markedly in spore and hyphal char? acters. Until a better understanding of the relationship of these species to other resupinate polypores is developed, we prefer to use the older generic name, Poria. The three species studied are apparently slash-rotting organisms, found only on dead timber. There are no records of any association with heart-rot in living trees. All three are cosmopolitan species in the North Temperate Zone and are widely distributed in North America. Poria luteoalba and P. rixosa are found on coniferous wood, and P. eupora, with rare exceptions, occurs on angiosperms. 827
Abstract A76: Curcumin inhibits head and neck squamous cell carcinoma (HNSCC) migration (2010)

Abstract Purpose: Curcumin has been shown to inhibit HNSCC cell proliferation through the AKT/MTOR pathway. We wanted to study the biological effects of curcumin-induced AKT/MTOR inhibition in HNSCC. Procedures: Soluble proteins (pS6, p4EBP1, FGF2 and MMP-9) extracted from cells treated with or without 20µM curcumin overnight were analyzed by western blot. Cell motility with and without 5, 10, and 20µM curcumin was determined by transwell migration assay and compared using one-way ANOVA in four HNSCC cell lines (FaDu, PCI15A, SCC40 and SCC066). Results: We used the highly invasive SCC cell line PCI15a to investigate the effects of curcumin on the AKT/MTOR pathway in vitro. Phosphorylated S6 (pS6) and p4EBP1 were inhibited in cells treated with 20µM curcumin for 24 hours. Curcumin inhibited the downstream effector FGF2 by 80% in SCC40 and completely abrogated the downstream effector MMP-9 in the PCI15a cell line. Compared to vehicle, curcumin significantly inhibited migration of the HNSCC cell lines in the transwell migration model. A significant dose-response was found among the four curcumin concentrations for all four cell lines compared to vehicle (p&amp;lt;0.001). Conclusions: Curcumin inhibits migration of HNSCC cell lines trough the AKT/MTOR pathway and its downstream targets. Cancer cell migration is a highly regulated process that permits dissemination from the primary tumor. Concentrations that inhibited cell proliferation through inhibition of AKT/MTOR and its downstream target MMP-9 were sufficient to inhibit the invasion of a variety of HNSCC cell lines in vitro. This sensitivity of HNSCC cells to retardation of cell migration by curcumin further highlights its chemopreventive properties. Citation Information: Cancer Prev Res 2010;3(1 Suppl):A76.