gebhart/patrepeval huggingface dataset:
Vibrio cholerae VibF Is Required for Vibriobactin Synthesis and Is a Member of the Family of Nonribosomal Peptide Synthetases (2000)

A 7.5-kbp fragment of chromosomal DNA downstream of the Vibrio cholerae vibriobactin outer membrane receptor, viuA, and the vibriobactin utilization gene, viuB, was recovered from a Sau3A lambda library of O395 chromosomal DNA. By analogy with the genetic organization of the Escherichia coli enterobactin gene cluster, in which the enterobactin biosynthetic and transport genes lie adjacent to the enterobactin outer membrane receptor, fepA, and the utilization gene, fes, the cloned DNA was examined for the ability to restore siderophore synthesis to E. coli ent mutants. Cross-feeding studies demonstrated that an E. coli entF mutant complemented with the cloned DNA regained the ability to synthesize enterobactin and to grow in low-iron medium. Sequence analysis of the cloned chromosomal DNA revealed an open reading frame downstream of viuB which encoded a deduced protein of greater than 2,158 amino acids, homologous to Yersinia sp. HMWP2, Vibrio anguillarum AngR, and E. coli EntF. A mutant with an in-frame deletion of this gene, named vibF, was created with classical V. cholerae strain O395 by in vivo marker exchange. In cross-feeding studies, this mutant was unable to synthesize ferric vibriobactin but was able to utilize exogenous siderophore. Complementation of the mutant with a cloned vibF fragment restored vibriobactin synthesis to normal. The expression of the vibF promoter was found to be negatively regulated by iron at the transcriptional level, under the control of the V. cholerae fur gene. Expression of vibF was not autoregulatory and neither affected nor was affected by the expression of irgA or viuA. The promoter of vibF was located by primer extension and was found to contain a dyad symmetric nucleotide sequence highly homologous to the E. coli Fur binding consensus sequence. A footprint of purified V. cholerae Fur on the vibF promoter, overlapping the Fur binding consensus sequence, was observed using DNase I footprinting. The protein product of vibF is homologous to the multifunctional nonribosomal protein synthetases and is necessary for the biosynthesis of vibriobactin.
Petrochemical Economics: Technology Selection in a Carbon Constrained World (2010)

This compendium gives an overview of the technologies and economics in the production of olefins in the petrochemical industries. It highlights the options and costs for producing olefins using different technologies and different feedstocks at a time when the cost of carbon dioxide emissions are set to be included in the production cost. Industry professionals, engineers, research scientists and financiers will find this title a valuable resource
A methodology for the design and implementation of virtual interfaces (1985)

Article A methodology for the design and implementation of virtual interfaces Share on Authors: Verlynda Dobbs Department of Computer Science, Wright State University, Dayton, Ohio Department of Computer Science, Wright State University, Dayton, OhioView Profile , Sandra A. Mamrak Department of Computer and Information Science, The Ohio State University, Columbus, Ohio Department of Computer and Information Science, The Ohio State University, Columbus, OhioView Profile Authors Info & Claims ACM '85: Proceedings of the 1985 ACM annual conference on The range of computing : mid-80's perspective: mid-80's perspectiveOctober 1985 Pages 158–173https://doi.org/10.1145/320435.320485Published:01 October 1985 1citation246DownloadsMetricsTotal Citations1Total Downloads246Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Comparison of the Kaufman Brief Intelligence Test and the Wechsler Intelligence Scale for Children—third edition in economically disadvantaged African American youth (1999)

The Kaufman Brief Intelligence Test (K-BIT; Kaufman & Kaufman, 1990) and the Wechsler Intelligence Scale for Children-Third Edition (WISC-III; Wechsler, 1991) are compared in 35 economically disadvantaged African American youth presenting for treatment in a community mental health setting. Significant correlations were found between K-BIT Composite and WISC-III Full Scale IQ scores. Results revealed significant differences between K-BIT and WISC-III scores; K-BIT Composite and Matrices mean scores were found to be 6 and 11 points higher than respective WISC-III Full Scale IQ and Performance IQ mean scores. No significant differences were obtained between K-BIT Vocabulary and WISC-III Verbal IQ scores. Our findings support the authors' recommendations for use of the Matrices subtest alone with African American youth from economically disadvantaged backgrounds (Kaufman & Kaufman, 1990).
An in vitro study of the effects of formulation variables and product structure on percutaneous absorption of lactic acid (1998)

The efficacy of lactic acid-containing products is linked to their ability to deliver it to specific skin strata. The penetration of L+ lactic acid to different skin layers of porcine skin from various emulsions was measured in vitro using flow-through diffusion cells. The effects of pH, propylene glycol, product structure, and mode of application on percutaneous absorption of lactic acid were investigated. The absorption of lactic acid from oil-in-water (o/w) emulsions was measured at pH 3.8 and 7.0. The effect of propylene glycol (5%) as a penetration enhancer for lactic acid was also investigated from an o/w emulsion. The emulsion was applied either as a finite-dose 2-pl topical film or as a 75-pl occluded patch on a 0.64-cm 2 skin disc. A key finding was that the effects of changes in product compositions such as vehicle pH and propylene glycol on percutaneous absorption of lactic acid depended on the application mode. Increasing the aqueous phase acidity in an oil-in-water emulsion enhanced lactic acid delivery in the finite dose but not in the infinite-dose application. Finite-dose films were significantly more efficient than infinite dose for lactic acid delivery to tissue compartments. The penetration enhancer propylene glycol was more efficacious at the infinite-dose application. However, it also significantly enhanced lactic acid delivery to viable epidermis in the finite-dose application. Finally, the effect of emulsion phase structure on lactic acid uptake was investigated by comparing delivery from oil-in-water (o/w), water-in-oil (w/o), and water-in-oil-inwater (w/o/w) multiple emulsions with identical compositions. The total tissue delivery of lactic acid from the three emulsions was in the order of o/w > w/o/w > w/o.
U-Helix: On-chip short conical antenna (2013)

The aggressive scaling of the CMOS technology and the convergence of CMOS and MEMS technologies along the “More Than Moore” axis of the International Technology Roadmap for Semiconductors, paves the way to the realization of millimeter-waves front-end circuits with integrated three-dimensional antennas. In this work we present a short conical helical antenna built applying MEMS micro-fabrication techniques whose dimensions can scale down to 100 μm (for operation in the THz region) and that can be integrated on silicon chips for communication and imaging purpose. Antenna design rules and methodology, electromagnetic characteristics and actual measurement are presented.
Teleport London International: the new alternative (1995)

The liberalisation of telecommunications policies in the United Kingdom has opened new commercial opportunities for independent satellite teleport operators. These new teleports have evolved to provide private earth station facilities for broadcasters and information service providers by means of permanent and occasional television broadcast and data services. The paper describes the way a UK based international broadcaster has grasped the opportunities provided by this deregulated environment by setting up a dedicated subsidiary company, Teleport London International (TLI). The subsidiary has made rapid progress during its first year of commercial operation and it has developed international partnerships to provide new distribution opportunities for news and broadcasting organisations. TLI is one of Europe's first major private international teleports. It offers a full range of analogue and digital satellite services in all radio and television standards for both full time and occasional traffic together with data services. It operates as a service provider in one of the most advanced, deregulated and competitive communications markets in the world.
A nomogram predicting disease‐free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (2011)

This nomogram can easily calculate the median and yearly disease-free survival rates from only 6 preoperative variables. This is a very useful tool to determine the likelihood of early recurrence and the necessity for perioperative chemotherapy in patients with colorectal liver metastases after hepatic resection.
Using code collection to support large applications on mobile devices (2004)

The progress of mobile device technology unfolds a new spectrum of applications that challenges conventional infrastructure models. Most of these devices are perceived by their users as appliances rather than computers and accordingly the application management should be done transparently by the underlying system unlike classic applications managed explicitly by the user. Memory management on such devices should consider new types of mobile applications involving mobility such as mobile agents, active networks and context aware applications. This paper describes a new management technique, called code and proposes a specific collection algorithm, the Adaptive Code Collection Algorithm (ACCAL). Code collection is a mechanism for transparently loading and discarding application components on mobile devices at runtime that is designed to permit very low memory usage and at the same time good performance by focusing memory usage on the hotspots of the application. To achieve these goals, ACCAL uses properties specific to executable and enhances conventional data management methods such as garbage collection and caching. The results show that fine-grained collection allows large applications to execute by using significantly less memory while inducing small execution time overhead.
Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation (1999)

Abstract IFN-γ antagonizes many physiological responses mediated by IL-4, including the inhibition of IL-4-induced IgE production. This event is largely mediated at the level of transcription. We observed that the IL-4 response element of the germline epsilon promoter is sufficient to confer IFN-γ-mediated repression onto a reporter construct. The inhibitory effects were observed in both lymphoid and nonlymphoid cell lines. Stat1, which is activated by IFN-γ, cannot recognize the Stat6-specific IL-4 response element in the ε promoter. Hence, competitive DNA binding does not seem to be the underlying mechanism for the inhibitory effect. This is supported by the observation that inhibition is not seen at early time points, but requires prolonged IFN-γ treatment. IFN-γ stimulation results in a loss of IL-4-induced Stat6 tyrosine phosphorylation, nuclear translocation, and DNA binding. Using the fibrosarcoma cell line U3A, which lacks Stat1, we demonstrated that the transcription activation function of Stat1 is required for the IFN-γ-mediated repression. Repression was restored by overexpression of Stat1α, but not Stat1β, in U3A cells. Treatment with IFN-γ, but not IL-4, specifically up-regulates the expression of SOCS-1 (silencer of cytokine signaling), a recently characterized inhibitor of cytokine signaling pathways, such as IL-6 and IFN-γ. Overexpression of SOCS-1 effectively blocks IL-4-induced Stat6 phosphorylation and transcription. This suggests that IFN-γ-mediated repression of IL-4-induced transcription is at least in part mediated by SOCS-1.
New Salts of the Waterstable P2Se64− Anion (2010)

The structures of two new salts of the P(2)Se(6)(4-) anion, [(py(2)Li)](4)[P(2)Se(6)].2py and [pyH](4)[P(2)Se(6)].H(2)O, prepared using a new synthetic route in solution starting from easily available educts, are presented. The salts are characterized also in solution by means of multinuclear ((31)P, (77)Se, (7)Li) NMR spectroscopy. The (31)P and (77)Se NMR spectrum of the waterstable P(2)Se(6)(4-) anion are discussed in detail for the first time. The chemical shift of the P(2)Se(6)(4-) anion in the Li(+) salts depends strongly on the solvent used. Remarkably, the newly synthesized salts are stable in water.
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality (2020)

Using a viral-induced hypomorph of GBF1, Navare et al., demonstrate that the principle of synthetic lethality is a mechanism to selectively kill virus-infected cells.
COMPUTING TRAIN SCHEDULES TO SAVE ENERGY: THE MARECO PROGRAM (1981)

After reviewing the present methods, the authors describe the principles, the computer-based information and two examples of application of the MARECO algorithm, minimizing energy at the wheel rim for a given running time; this is achieved by means of a judicious compromise between a reduction in maximum running speeds and the use of coasting.
Increased Proteolysis and Leucine Aminopeptidase Activity in Faeces of Patients with Crohn’s Disease (1988)

Proteolytic and leucine aminopeptidase activity levels in faeces from patients with Crohn's disease and healthy subjects were compared and were found to be 2.5 and 6 times higher, respectively, in patients with Crohn's disease. Patients who had undergone partial bowel resection even showed a 12- and 40-fold increase of enzyme activities. A part of the elevated levels of faecal proteases probably results from ileal malabsorption. This was supported by studies in germ-free and conventional rats showing that the ileum is the major site of absorption of digestive proteolytic enzymes and leucine aminopeptidase. The other part of the increased protease activity was attributed to the abnormal anaerobic faecal flora of patients with Crohn's disease. Interactions between flora and enzymes were studied in rats. The resident flora of the caecum was found to stimulate absorption, or to inactivate the major part of the remaining enzymes. The elevated levels of faecal proteases in Crohn's disease may play a role in the damage of the intestinal mucosa.
Evaluation of Extended Electro Motive Force Observer Dynamic Performances Using Complex Vectors (2019)

Extended Electro Motive Force Observers in the estimated synchronous reference frame allow to estimate rotor position at medium and high speeds for Interior Permanent Magnet Synchronous Machines. This paper focuses on the analysis of the dynamic performances of these observers. Use of complex vector modeling allows to demonstrate that these performances are speed dependent. In order to overcome this problem, a Complex Vector Observer is proposed. It is proven that this structure achieves good robustness against load torque and speed variations over different operating conditions. An improved phase detector is also presented, to solve the common speed reversal problems of the back-EMF based methods.
Saint Louis en prière (2002)

Attribué à Joseph PiazzaGignac – Église Saint-MartinH 179 - L 133 Cette œuvre, qui relève de l’imagerie pieuse, reprend les trois aspects de la représentation traditionnelle de saint Louis : le roi, le saint et le croisé. Louis est revêtu du manteau fleurdelisé, vêtement officiel du sacre des rois de France. La richesse de ce vêtement, de velours bleu brodé d’or et doublé d’hermine, confirme toute la noblesse et le prestige du personnage. Mais celui-ci, prosterné devant un autel, tête nue et ...
Evaluation of electrical insulation exposed to amorphous metal transformer core annealing temperature (1985)

An evaluation of potential coil insulation materials for an oil-filled amorphous metal cored distribution transformer is presented. The design concept assumed requires the transformer core and windings be subjected to the amorphous metal core annealing temperature-time cycle during manufacture.
Directing Gold Nanoparticles into Free‐Standing Honeycomb‐Like Ordered Mesoporous Superstructures (2019)

2D mesoporous materials fabricated via the assembly of nanoparticles (NPs) not only possess the unique properties of nanoscale building blocks but also manifest additional collective properties due to the interactions between NPs. In this work, reported is a facile and designable way to prepare free-standing 2D mesoporous gold (Au) superstructures with a honeycomb-like configuration. During the fabrication process, Au NPs with an average diameter of 5.0 nm are assembled into a superlattice film on a diethylene glycol substrate. Then, a subsequent thermal treatment at 180 °C induces NP attachment, forming the honeycomb-like ordered mesoporous Au superstructures. Each individual NP connects with three neighboring NPs in the adjacent layer to form a tetrahedron-based framework. Mesopores confined in the superstructure have a uniform size of 3.5 nm and are arranged in an ordered hexagonal array. The metallic bonding between Au NPs increases the structural stability of architected superstructures, allowing them to be easily transferred to various substrates. In addition, electron energy-loss spectroscopy experiments and 3D finite-difference time-domain simulations reveal that electric field enhancement occurs at the confined mesopores when the superstructures are excited by light, showing their potential in nano-plasmonic applications.
Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine (2014)

Hydroxychloroquine (HCQ) has been shown to demonstrate anti-inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time the fabrication and in vitro evaluation of two types of intravaginal ring (IVR) devices (a surfaced-modified matrix IVR and a reservoir segmental IVR) for achieving sustained delivery (>14 days) of HCQ as a strategy for preventing male-to-female transmission of HIV. Both IVRs were fabricated by hot-melt injection molding. Surface-modified matrix IVRs with polyvinylpyrrolidone or poly(vinyl alcohol) coatings exhibited significantly reduced burst release on the first day (6.45% and 15.72% reduction, respectively). Reservoir IVR segments designed to release lower amounts of HCQ displayed near-zero-order release kinetics with an average release rate of 28.38 μg/mL per day for IVRs loaded with aqueous HCQ and 32.23 μg/mL per day for IVRs loaded with HCQ mixed with a rate-controlling excipient. Stability studies demonstrated that HCQ was stable in coated or noncoated IVRs for 30 days. The IVR segments had no significant effect on cell viability, pro-inflammatory cytokine production, or colony formation of vaginal and ectocervical epithelial cells. Both IVR systems may be suitable for the prevention of HIV transmission and other sexually transmitted infections.
Hemorrhage Control Research on Today's Battlefield: Lessons Applied (2007)

McManus, John G. MD, MCR; Eastridge, Brian J. MD; Wade, Charles E. PhD; Holcomb, John B. MD Author Information
Telomere and telomerase in stem cells (2007)

Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. In embryonic stem cells, telomerase is activated and maintains telomere length and cellular immortality; however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells.
Zur Synthese von 22,26‐Epiminocholestanolen (1978)

Synthesis of 22,26‐Epiminocholestanols The synthesis of the 22,26‐epiminocholestanol derivative solacongestidine ( 3 ) from solasodine is improved using diisobutylaluminium hydride for the removal of the N ‐acetyl group of 1 to give 2 .
'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans (2005)

The cardinal effects of cytotoxic drugs found in this study were tapering of the proximal hair shaft and premature entry of the follicle into telogen, conflicting with the conventional view that affected hair follicles continue in anagen. There was a resulting effluvium of a mixture of tapering telogen hairs and fractured hairs. As entry into telogen is an integral part of the process, cytotoxic hair loss may be regarded as a variant of the conventional 'telogen effluvium' and we propose the term 'atrophic telogen effluvium'. There was no obvious protective effect on the hair loss of prior treatment with topical calcipotriol.
Hirudotherapy in Wound Healing (2020)

Leeches are hermaphrodite, bloodsucking parasitic worms usually found in places with fresh water. Leech therapy existed 3000 years, and it is being used at a different scope. Several species of leeches have been used in medicine, and the most common species used is <i>Hirudo medicinalis</i>. Leeches suck the excess blood, reduce the swelling in the tissues, and promote healing by allowing fresh oxygenated blood to reach the area until normal circulation can be restored. Pain relief from leech therapy is rapid, effective, and long-lasting in many conditions. The aim of this study was to evaluate the efficacy and duration of healing utilizing sterile medicinal leeches, <i>Hirudinaria manillensis</i>, in the management of pain and wound healing. Leech was taken out from its sterile tube by using a pair of non-tooth sterile plastic forceps and gloved hands. Each leech was left in place for as long as it was feeding. Leeches were removed only after they became detached from the patient. The specimen jars containing the used leeches were sealed in either a biohazard bag or in a small yellow clinical waste bin liner securely fastened with a cable tie. The leech was killed by using 70% alcohol prior to disposal into a yellow hazard bin, which undergoes incineration. All 3 patients had improvements in their condition, especially in terms of reduction in the pain and improvement in their sense of balance. All the wounds healed well. Therefore, leech therapy is effective in reducing pain and increasing perfusion to allow the wounds to heal quickly. However, a more robust trial is needed to show significance as the sample size is small.
ChemInform Abstract: UMSETZUNG VON ALPHA,BETA‐DIBROMKETONEN MIT THIOHARNSTOFF UND SUBSTITUIERTEN THIOHARNSTOFFEN (1970)

Abstract Die Dibromketone (II), die durch Addition von Brom an die ungesättigten Ketone (I) dargestellt werden, kondensieren mit Thioharnstoff oder substituierten Thioharnstoffen (III) zu Thiazolen (IV).