gebhart/patrepeval huggingface dataset:
Total recall (2004)

Total Recall is a system that records an individual perspective of the world using personal sensors such as a microphone in a pair of glasses or a camera in a necklace. There are many applications of Total Recall -- patients accurately recording what they've recently eaten, students replaying any part of a class, and so on--that can significantly improve people's quality of life. However, data recorded by such a system may be also used by the judicial system without the consent of the user or of those being recorded. Pervasive use of systems like Total Recall will likely change our social structure as memory becomes vastly more reliable and complete. It is natural then that privacy advocates might consider such technology dangerous because such data can be used in unanticipated ways by government agencies or third-party civil litigants. In this paper, we discuss privacy concerns in the context of systems like Total Recall and propose a solution that may alleviate some of these concerns. We discuss the ramifications of this solution and its possible implementations.
[From accreditation to certification. Quality management in a radiology department]. (1999)

The leaders of a radiology department started a quality process based on ISO 9001 certification and the total quality management program. The purpose of this work is to match the conformity of this quality system to ANAES recommendations. If the concordance is obvious, the advantages of using quality insurance to get an accreditation are important. In conclusion, a quality process is proposed, it includes a quality insurance manual of ISO 9001 norm, the total quality management in the first point of the norm and the ANAES recommendations spread over the 20 points of the norm.
Physical mechanisms in neuroelectromagnetic therapies (2002)

Physical parameters that are used to characterize different types of electromagnetic devices used in neurotherapy can include power, frequency, carrier frequency, current, magnetic field intensity, and whether an application is primarily electric or primarily magnetic. Currents can range from tens of microamperes to hundreds of milliamperes, magnetic fields from tens of microtesla to more than one tesla, and frequencies from a few Hz to more than 50 GHz. A division into three device categories is proposed, based on the current applied and the specificity of the therapeutic signal. Two research areas have great potential for new neuroelectromagnetic strategies. Studies of endogenous neural oscillatory states suggest using external fields to reinforce or inhibit such states. Also, various independent groups have reported that weak magnetic fields, in particular ion cyclotron resonance fields, are capable of sharply altering behavior in rats.
Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents (2006)

In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
Precise localization of a UAV using visual odometry (2015)

Within the AEROWORKS group at the UT we are researching aerial manipulation. The manipulators we develop have to be tested on a UAV. Indoors we can fly using the OptiTrack motion capturing system. This project focuses on creating a setup which enables us to experiment with aerial manipulation in an outdoor environment. Precise localization is necessary to perform the aerial manipulation tasks. GPS doesn't offer enough precision for these tasks. We aim at using stereo vision to observe the environment and localize the UAV since cameras provide a lot of information about the environment whilst being light-weight and compact. The VI-sensor used in this project combines a stereo camera with an IMU. Visual odometry is the process of obtaining motion from camera images. These measurements are fused with the IMU measurements to obtain a high-bandwidth pose of the VI-sensor. A working setup with a hexacopter carrying a VI-sensor has been created which can fly using the pose estimation obtained by visual odometry.
Using Aggregation to Improve the Scheduling of Flexible Energy Offers (2012)

Changing electricity markets call for new ways of handling supply and demand. The desired goal is to increase the utilization of renewable energy while ensuring reliable supply and minimizing the costs. We present an approach aiming at this goal that handles a large number of flexible energy offers from producers and consumers by aggregating them and scheduling these aggregates to minimize a cost function. We explore the influence of aggregation on the performance of scheduling, establishing that a trade-off between keeping the flexibilities of flexible offers and reducing their number is what yields the best results.
The Expression Pattern of a Cav3-Kv4 Complex Differentially Regulates Spike Output in Cerebellar Granule Cells (2014)

The cerebellum receives sensory information by mossy fiber input from a multitude of sources that require differential signal processing. A compartmentalization of function begins with the segregation of mossy fibers across 10 distinct lobules over the rostrocaudal axis, with tactile receptor afferents prevalent in anterior lobules and vestibular input in caudal lobules. However, it is unclear how these unique signals might be differentially processed at the circuit level across the cerebellum. As granule cells receive mossy fiber input, they represent a key stage at which postsynaptic mechanisms could influence signal processing. Granule cells express an A-type current mediated by Kv4 potassium channels that modify the latency and frequency of spike output. The current study examined the potential for a Cav3 calcium-Kv4 channel complex to regulate the response of granule cells to mossy fiber input in lobules 2 and 9 of the rat cerebellum. Similar A-type currents were recorded in both regions, but the Cav3 calcium current was expressed at a substantially higher density in lobule 9 cells, acting to increase A-type current availability through its influence on Kv4 voltage for inactivation. The difference in excitability imparted by Cav3-Kv4 interactions proves to allow lobule 2 granule cells to respond more effectively to tactile stimulus-like burst input and lobule 9 cells to slow shifts in input frequency characteristic of vestibular input. The expression pattern of Cav3 channels and its control of Kv4 availability thus provides a novel means of processing widely different forms of sensory input across cerebellar lobules.
Gibberellin Promotes Shoot Branching in the Perennial Woody PlantJatropha curcas (2015)

Strigolactone (SL), auxin and cytokinin (CK) interact to regulate shoot branching. CK has long been considered to be the only key phytohormone to promote lateral bud outgrowth. Here we report that gibberellin also acts as a positive regulator in the control of shoot branching in the woody plant Jatropha curcas. We show that gibberellin and CK synergistically promote lateral bud outgrowth, and that both hormones influence the expression of putative branching regulators, J. curcas BRANCHED1 and BRANCHED2, which are key transcription factors maintaining bud dormancy. Moreover, treatment with paclobutrazol, an inhibitor of de novo gibberellin biosynthesis, significantly reduced the promotion of bud outgrowth by CK, suggesting that gibberellin is required for CK-mediated axillary bud outgrowth. In addition, SL, a plant hormone involved in the repression of shoot branching, acted antagonistically to both gibberellin and CK in the control of lateral bud outgrowth. Consistent with this, the expression of JcMAX2, a J. curcas homolog of Arabidopsis MORE AXILLARY GROWTH 2 encoding an F-box protein in the SL signaling pathway, was repressed by gibberellin and CK treatment. We also provide physiological evidence that gibberellin also induces shoot branching in many other trees, such as papaya, indicating that a more complicated regulatory network occurs in the control of shoot branching in some perennial woody plants.
Enzymatic, Polymer-Supported Formation of an Analog of the Trypsin Inhibitor A90720A:  A Screening Strategy for Macrocyclic Peptidase Inhibitors (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnzymatic, Polymer-Supported Formation of an Analog of the Trypsin Inhibitor A90720A: A Screening Strategy for Macrocyclic Peptidase InhibitorsMatthew T. Burger and Paul A. BartlettView Author Information Department of Chemistry, University of California Berkeley, California 94720-1460 Cite this: J. Am. Chem. Soc. 1997, 119, 51, 12697–12698Publication Date (Web):December 24, 1997Publication History Received17 April 1997Published online24 December 1997Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/ja971216chttps://doi.org/10.1021/ja971216crapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views717Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cyclization,Inhibitors,Organic compounds,Peptides and proteins,Precursors Get e-Alerts
STING expression and response to treatment with STING ligands in premalignant and malignant disease (2017)

Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma. We demonstrate that STING ligands cause rapid regression of papilloma, associated with T cell infiltration, and are significantly more effective than Imiquimod, a current immunotherapy for papilloma. In humans, we show that STING is expressed in the basal layer of normal skin and lost during keratinocyte differentiation. We found STING was expressed in all HPV-associated cervical and anal dysplasia and was strongly expressed in the cancer cells of HPV+ HNSCC but not in HPV-unrelated HNSCC. We found no strong association between STING expression and progressive disease in non-HPV oral dysplasia and oral pre-malignancies that are not HPV-related. These data demonstrate that STING is expressed in basal cells of the skin and is retained in HPV+ pre-malignancies and advanced cancers, but not in HPV-unrelated HNSCC. However, using a murine HNSCC model that does not express STING, we demonstrate that STING ligands are an effective therapy regardless of expression of STING by the cancer cells.
SCHOTTEL PROPULSION UNITS FOR SHALLOW WATER TUG OPERATIONS (1985)

Shallow draught propulsion has always been a problem and this article gives a solution which combines the advantage of extreme manoeuvrability. Examples are given of vessels built with the system. .
Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target “calcitonin gene related peptide” receptor using in silico analysis (2019)

Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide receptor (CGRP) when associates with human receptor activity-modifying protein-1 (HRAMP1). CGRP is believed to be involved in triggering of migraine. Many strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target “CGRP receptor” as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the liver. The present study, evaluated the binding of 13 phyto-chemical compounds of “Abrus precatorius” identified through GCMS analysis against the protein CGRP using “Discovery Studio software”. The molecular docking study and ADME/T properties prediction were performed with the compounds using C-DOCKER module. The results showed that five lead compounds of A. precatorius may act as good inhibitors for migraine headache and the compounds can be re-designed and synthesized for better antimigraine activity. Keywords: Calcitonin gene-related peptide, Abrus precatorius Linn, Discovery studio, Migraine, C-DOCKER, ADME properties
Fluidized Bed Denitrification of Secondary Effluent during Wastewater Reclamation in Southern California (1996)

A pilot scale fluidized bed denitrification bioreactor was operated for a period of three years as one unit process in a series designed to repurify secondary effluent for subsequent indirect potable reuse. This paper presents data collected during the third year of operation.
Adaptive Optical System Atmospheric Turbulence Generator Test-bed (2007)

At the Naval Research Laboratory (NRL), we have developed a testbed for simulating atmospheric turbulence using Kolmogorov statistics for testing the correctibility of an Adaptive Optical System (AOS). In this testbed, a Liquid Crystal Spatial Light Modulator is being used to induce the atmospheric turbulence and a MEM deformable mirror is being used in the AOS to correct it. This atmospheric turbulence generator can be used to simulate the atmospheric effects on light viewed by an AOS for any telescope aperture with either very poor or very good seeing conditions. This dynamic and expandable system is being used to characterize performance and optimization parameters of our AOS at NRL. 1.
Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide (2005)

Inflammation is a prominent feature of several disorders characterized by primary demyelination, but it is not clear whether a relationship exists between inflammation and myelin damage. We have found that substantial demyelination results from the focal inflammatory lesion caused by the injection of lipopolysaccharide (LPS; 200 ng) directly into the rat dorsal funiculus. Within 24 h, such injections caused a focal inflammatory response consisting of a substantial number of polymorphonuclear cells and ED1-positive and inducible nitric oxide synthase (iNOS)-positive macrophages/microglia. The number of inflammatory cells was substantially reduced by day 7. OX-52-positive T-cells were less frequently observed but were present in the meninges at 8 h, reached a maximum in the dorsal funiculus at 7 days, and were rare at 14 days. The inflammation was followed by the appearance of a large lesion of primary demyelination that encompassed up to approximately 75% of the cross-sectional area of the dorsal funiculus. Treatment with dexamethasone significantly reduced the number of cells expressing iNOS, but did not prevent the demyelination. By 28 days the lesions were largely remyelinated, usually by Schwann cells. These changes were not observed in control, saline-injected animals. We conclude that the intraspinal injection of LPS results in inflammation and subsequently in prominent demyelination. The mechanisms underlying the demyelination are not clear, but it is notable that it typically begins with disruption of the adaxonal myelin. Indeed, there is an early loss of myelin-associated glycoprotein within the lesion, despite the persistence of proteolipid protein. This combination is a feature of the pattern III lesion recently described in multiple sclerosis (Lucchinetti et al., 2000), and we therefore suggest that LPS-induced demyelination may serve as the first experimental model available for the study of this type of multiple sclerosis lesion.
Content-based retrieval of video sequences under partial occlusion (2003)

In this paper, we present a spatio-temporal segmentation method for content-based video retrieval. Our method is effective in the presence of partial occlusion or when new areas become exposed. In addition, periodic spatial segmentation is not performed. Rather, it is invoked as needed depending on whether or not new regions have been detected. A discussion of how this method can be used for content-based retrieval is also provided. Finally, experimental results that demonstrate the performance of the proposed spatio-temporal segmentation method are presented.
Our Lady of Light Academy, Santa Fé (1938)

ANTA FE has long been the seat of civil, military and ecclesiastical government.. Church and state were planted there when America was El Nuevo Mundo
Strip wound prestressed die with high strength and high rigidity (2011)

Based on the high demand on strength and rigidity of dies used in precision cold forging and industrial diamond synthesizing with service condition of ultra-high pressure in material processing,completed analyses are carried out on the structure and existing problems of the traditional compound prestressed die.The properties and technical advantages of strip wound prestressed die are introduced.Basic principle and design method of strip wound prestressed die are presented.The special equipment to manufacture strip wound prestressed die are developed.Tension controlling principle and method are also presented.
On the Development of Quantitative Operator Situational Awareness Assessment Methods for Small-Scale Unmanned Aircraft Systems (2022)

Small-Scale Unmanned Autonomous Systems <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(sUASs)$</tex> have become an integral part of situation assessment and decision support tasks across a multitude of application domains. Evaluation methods that provide decisive comparisons between different sUAS platforms are critical for not only selecting suitable sUASs, but also for making sure that the chosen sUAS platform can satisfy the required minimum capabilities for a given application. Toward developing sUAS test methods, a new quantitative Operator Situation Awareness (OSA) assessment method is presented for evaluating and comparing sUAS platforms for their ability to provide adequate levels of Situation Awareness (SA) in subterranean (SubT) environments. The work presented here improves upon our previous work based on Attention Allocation Model <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(AAM)$</tex> and Man-Machine Integration Design and Analysis (MIDAS)-based SA model by (a) applying formulas to the Salience, Effort, Expectancy, and Value (SEEV) model for accurate quantification and (b) utilizing improved experiments with new operationally relevant scenarios designed to validate those formulas. In particular, our new OSA assessment method accounts for spatial perception differences across platforms by introducing a new component that we refer to as Virtual Proportion, which is obtained from Attention Allocation Proportion of other other Situation Elements by comparing the correct rate of Situation Awareness Global Assessment Technique (SAGAT). Our approach is illustrated via USA comparison of two (02) military-grade sUAS platforms. The paper concludes with a discussion on potential future expansions.
Open-Path Tunable Diode Laser Absorption Spectroscopy for Acquisition of Fugitive Emission Flux Data (2005)

Air pollutant emission from unconfined sources is an increasingly important environmental issue. The U.S. Environmental Protection Agency (EPA) has developed a ground-based optical remote-sensing method that enables direct measurement of fugitive emission flux from large area sources. Open-path Fourier transform infrared spectroscopy (OP-FTIR) has been the primary technique for acquisition of pollutant concentration data used in this emission measurement method. For a number of environmentally important compounds, such as ammonia and methane, open-path tunable diode laser absorption spectroscopy (OP-TDLAS) is shown to be a viable alternative to Fourier transform spectroscopy for pollutant concentration measurements. Near-IR diode laser spectroscopy systems offer significant operational and cost advantages over Fourier transform instruments enabling more efficient implementation of the measurement strategy. This article reviews the EPA's fugitive emission measurement method and describes its multipath tunable diode laser instrument. Validation testing of the system is discussed. OP-TDLAS versus OP-FTIR correlation testing results for ammonia (R2 = 0.980) and methane (R2 = 0.991) are reported. Two example applications of tunable diode laser-based fugitive emission measurements are presented.
Faculty Opinions recommendation of Inhibition of the TRPC5 ion channel protects the kidney filter. (2014)

An intact kidney filter is vital to retention of essential proteins in the blood and removal of waste from the body. Damage to the filtration barrier results in albumin loss in the urine, a hallmark of cardiovascular disease and kidney failure. Here we found that the ion channel TRPC5 mediates filtration barrier injury. Using Trpc5-KO mice, a small-molecule inhibitor of TRPC5, Ca2+ imaging in isolated kidney glomeruli, and live imagining of podocyte actin dynamics, we determined that loss of TRPC5 or its inhibition abrogates podocyte cytoskeletal remodeling. Inhibition or loss of TRPC5 prevented activation of the small GTP-binding protein Rac1 and stabilized synaptopodin. Importantly, genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria. These data reveal that the Ca2+-permeable channel TRPC5 is an important determinant of albuminuria and identify TRPC5 inhibition as a therapeutic strategy for the prevention or treatment of proteinuric kidney disease. PMID: 24231357 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: DK083511 NIDDK NIH HHS, United States Grant ID: R56 DK093746 NIDDK NIH HHS, United States Grant ID: P30 DK057521 NIDDK NIH HHS, United States Grant ID: K08 DK083511 NIDDK NIH HHS, United States Grant ID: P30DK057521 NIDDK NIH HHS, United States Grant ID: DK093783 NIDDK NIH HHS, United States Grant ID: R01 DK099465 NIMH NIH HHS, United States Grant ID: U54 MH084659 NIDDK NIH HHS, United States Grant ID: R01 DK095045 NIDDK NIH HHS, United States Grant ID: DK093746 NIDDK NIH HHS, United States Grant ID: K08 DK093783 More Less keyboard_arrow_down