gebhart/patrepeval huggingface dataset:
.delta.-Patchoulene, an acid-catalyzed transformation product of patchouli alcohol (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.delta.-Patchoulene, an acid-catalyzed transformation product of patchouli alcoholBraja D. Mookherjee, Robert W. Trenkle, and Walter O. LedigCite this: J. Agric. Food Chem. 1974, 22, 5, 771–773Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/jf60195a023https://doi.org/10.1021/jf60195a023research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Revisiting the role of testosterone: Are we missing something? (2017)

Testosterone is a pleiotropic hormone that plays an important role in the human body. Classically, testosterone was thought to be predominantly involved in androgenesis and physiology in boys and men. Through its conversion to estrogen, testosterone affects bone health, including bone density. Recently, there has been a renewed interest in the systemic role of testosterone in pain, well-being, and cardiovascular function in women and men alike. In this review, we discuss the historic significance of testosterone, its traditionally known physiology, and its molecular and cellular effects. We also discuss evidence for testosterone’s lesser known effects, including its role in women’s health. We suggest a need to revisit the clinical role of testosterone given its potential for applications to treat mood, cognitive health, and other illnesses, and its anabolic role in bone and muscle; we also suggest consideration of the current debate on risks of its use.
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis (2020)

Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes1. The nucleotides ATP and UTP represent one class of find-me signals2, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells. Pharmacological inhibition and siRNA-mediated knockdown of PANX1 led to decreased nucleotide release and monocyte recruitment by apoptotic cells. Conversely, PANX1 over-expression enhanced nucleotide release from apoptotic cells and phagocyte recruitment. Patch-clamp recordings showed that PANX1 was basally inactive, and that induction of PANX1 currents occurred only during apoptosis. Mechanistically, PANX1 itself was a target of effector caspases (caspases 3 and 7), and a specific caspase-cleavage site within PANX1 was essential for PANX1 function during apoptosis. Expression of truncated PANX1 (at the putative caspase cleavage site) resulted in a constitutively open channel. PANX1 was also important for the ‘selective’ plasma membrane permeability of early apoptotic cells to specific dyes3. Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases.
Design considerations for a dynamic metamaterial aperture for computational imaging at microwave frequencies (2016)

We investigate the imaging capabilities of a one-dimensional, dynamic, metamaterial aperture that operates at the lower part of K-band microwave frequencies (17.5–21.1 GHz). The dynamic aperture consists of a microstrip transmission line with an array of radiating, complementary, subwavelength metamaterial irises patterned into the upper conductor. Diodes integrated into the metamaterial resonators provide voltage-controlled switching of the resonant metamaterial elements between radiating and nonradiating states. Applying a series of on/off patterns to the metamaterial resonators produces a series of distinct radiation patterns that sequentially illuminate a scene. The backscattered signal contains encoded scene information over a set of measurements that can be postprocessed to reconstruct an image. We present a series of design considerations for the dynamic aperture, as well as a series of experimental studies performed using a dynamic aperture prototype. High-fidelity, real-time, diffraction-limited imaging using the prototype is demonstrated. The dynamic aperture suggests a path to fast and reliable imaging with low-cost and versatile hardware, for a variety of applications including security screening, biomedical diagnostics, and through-wall imaging.
Imaging of tissue disorder by the entropy of susceptibilities determined with second harmonic generation Stokes-Mueller polarimetric microscopy (2017)

Nonlinear optical polarimetry techniques, such as the second-harmonic generation (SHG) microscopy, reveal ultrastructural organization of materials including extracellular matrix of biological tissue. The nonlinear Stokes-Mueller polarimetry can measure the heterogeneity of media by determining entropy of susceptibilities.
Plasticisation effects of high-pressure carbon dioxide on polymers (2008)

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.
Synthetic Reactions by Complex Catalysts. XIV. Reaction of Isocyanide with Amine Catalyzed by Group IB and IIB Metal Compounds (1969)

Abstract Group IB and IIB metal compounds catalyze the reaction of isocyanides (1) with amines (2) producing formamidines (3). In the reaction of cyclohexyl isocyanide with piperidine, the accelerating effect of catalyst was in the order AgCl&amp;gt;CuCl&amp;gt;&amp;gt;ZnCl2, Cd(OAc)2, HAuCl4·4H2O. The AgCl catalyzed reaction proceeded almost quantitatively in 2.5 hr at 17°C. The reaction of aliphatic isocyanide with aromatic amine, e.g., N-methylaniline, required higher reaction temperatures (160°C) even in the presence of catalyst, in which the order of catalytic activity was HAuCl4·4H2O&amp;gt;ZnCl2&amp;gt;AgCl&amp;gt;&amp;gt;CuCl. A ternary complex of (CuCl)2 (cyclohexyl isocyanide)2 (piperidine) was isolated, which was unstable and decomposed gradually at room temperature to give N-cyclohexyl-N,N′-pentamethylene formamidine. A mechanism through a mixed ligand complex has been proposed, in which both isocyanide and amine are coordinated with the same metal ion and the reaction takes place in the sphere of complex ligand.
Effect of shockwave-induced density jump on laser plasma interactions in low-pressure ambient air (2006)

The dynamics of laser-produced plasma (LPP) and its shockwave-induced density jump (SIDJ) were investigated in low-pressure ambient air during the laser pulse using an optical interferometer. A tiny SIDJ could be observed clearly in ambient air with pressure as low as 3 Torr even during the rising edge of a 7 ns laser pulse. It was shown that the density jump and ionization could seed laser-induced ambient air breakdown at a relatively low pressure, which could significantly reduce laser energy deposited in the LPP. The ionization of the density jump was confirmed by dynamic emission imaging.
Transmission-Based Dielectric Probes for Surgical Applications (2019)

We have developed a new type of transmission-based dielectric probe that is idea for certain surgical applications - most notably spinal fusion surgery. It utilizes small-diameter open-ended coaxial cables, but exploits the fact that for the vertebrae surgery, the surgeon has access to both sides of the bone. While the space separation needs to be small (&amp;lt;2 cm), it is sufficiently large to get a signal across. The mathematics is dramatically simplified since it operates in the far field for which a number of simplifications can be employed. The penetration depth is effectively the full span between the two probes which is dramatically larger than that for open-ended coaxial reflection-based probes. Because it operates in the transmission mode, the effects from cable bending and such are minimal and subsequently lends itself to hand held operation which will be critical for a surgical setting.
IR Detectors using Pb (Mg<sub>1/3</sub>Nb<sub>2/3</sub>) O<sub>3</sub> and Pb (Sc<sub>1/2</sub>Ta<sub>1/2</sub>) O<sub>3</sub> Ceramics under DC Bias (1993)

Recently, one of thermal-type IR detectors, a pyroelectric sensor has a great interest in applications to commercial uses because of their working temperatures without cooling, a constant detectivity with independent of wavelength and a cheaper price. The conventional pyroelectric materials are usually normal ferroelectrics with a first or a second phase transition. The working temperatures prefer to enough below the Curie temperature, Tc, for the stable responsivity to temperature. Electric field induced-type pyroelectric sensors have also been proposed. Relaxor ferroelectrics such as Pb(Mg1/3Nb2/3)O3 (PMN) and Pb(Sc1/2Ta1/2)O3 (PST) which have a glassy Curie temperature near room temperature are used as this type sensors.This paper describes the sensor properties of electric field induced-type pyroelectric sensors prepared by using PMN and PST ceramics compared with the conventional type sensors. Material evaluations of PMN and PST ceramics were made to dielectric and pyroelectric properties. PMN shows the excellent induced pryoelectric properties for the sensors over wide range of temperature. On the other hand, PST seems to be inadequate for an IR detector because of a very narrow temperature range to high response. Prepared sensors with PMN and PST ceramics show enhanced pyroelectric activities under DC bias field. Measured sensor voltage-responsivities agree with those of calculated values for the PMN case. The electric field induced-type infrared sensor with the thick or thin film materials seems to be fine as linear array IR detectors for thermal imaging by means of application of higher electric field.
Supplementary Figure 2 from A <i>KRAS</i>-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk (2023)

Supplementary Figure 2 from A &lt;i&gt;KRAS&lt;/i&gt;-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk
Shortest Feasible Paths with Charging Stops for Battery Electric Vehicles (2019)

We study the problem of minimizing overall trip time for battery electric vehicles in road networks. As battery capacity is limited, stops at charging stations may be inevitable. Careful route planning is crucial because charging stations are scarce and recharging is time-consuming. We extend the constrained shortest-path problem for electric vehicles with realistic models of charging stops, including varying charging power and battery-swapping stations. Although the resulting problem is theoretically hard, we propose a combination of algorithmic techniques to achieve good performance in practice. Extensive experimental evaluation shows that our approach (CHArge) enables computation of optimal solutions on realistic inputs even of continental scale. Finally, we investigate heuristic variants of CHArge that derive high-quality routes in well below a second on sensible instances.
ChemInform Abstract: REACTION OF O,O‐DIMETHYLPHENACYL HALIDES WITH FORMAMIDE. FORMATION OF 4(5)‐(O,O‐DIMETHYLBENZOYL)IMIDAZOLE (1978)

Abstract Die α‐Halogen‐acetophenone (Ia), (Ib) reagieren mit Formamid bei verschiedenen Temperaturen überwiegend zu den Benzoyl‐imidazolen (IIa) und (IIb), während das Acetophenon (Ic) das Phenylimid‐ 90 azol (VIIIc) liefert.
Influence of Surface Finish of Cu Electrode on Shear Strength and Microstructure of Solder Joint with Sn-3Ag-0.5Cu (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Parametric Studies of Geometric Design Factors on Static and Dynamic Loading of an Origami Flasher (2017)

The “flasher” pattern (an origami base that folds into a 3D structure that can be radially deployed into a 2D surface) has been recognized for its potential application in the deployment of large structures from relatively small volumes. Such structures can be internally deployed by smart materials or stored strain energy, or externally deployed by actuators or inertial forces. Various flasher folding patterns can be created by varying three basic geometric parameters: (1) the number of sides of the center polygon, (2) the number of rings comprising the array, and (3) the number of radially-distributed elements of each ring. In this paper, these three parameters are studied for their effect on dynamic performance, using multi-body dynamic (MBD) simulation software. As a basis for comparison, all the designs are held to the same surface area in the deployed flat state. Each MBD model is created automatically by a series of previously reported scripts that transform a crease pattern into a fully defined engineering model. The primary focus is to investigate the variation of (a) the deployment time, (b) reaction torque at the center of the flasher, (c) force and torque distribution in the entire structure, (d) bending angle of the panels, and (e) rigid foldability. An experimental test-bed is also described, with provision of preliminary physical validation results. The overall effort provides insight to force distribution within the structure, which can guide the placement of integrated smart material actuators. The results also help in flasher design parameter decisions by giving insight into their effect on future applications such as star occulter designs, solar arrays, solar reflectors, sunshields, smallsat antennas, and solar sails.
The Ontolingua Server : a Tool for Collaborative Ontology Construction (1996)

Reusable ontologies are becoming increasingly important for tasks such as information integration, knowledge-level interoperation, and knowledge-base development. We have developed a set of tools and services to support the process of achieving consensus on common shared ontologies by geographically distributed groups. These tools make use of the world-wide web to enable wide access and provide users with the ability to publish, browse, create, and edit ontologies stored on an ontology server. Users can quickly assemble a new ontology from a library of modules. We discuss how our system was constructed, how it exploits existing protocols and browsing tools, and our experience supporting hundreds of users. We describe applications using our tools to achieve consensus on ontologies and to integrate information. The Ontolingua Server may be accessed through the URL http://ontolingua.stanford.edu:5915/ 1. INTRODUCTION 1.1 The Need for Ontologies In order for an agent to make statements ...
Identification and characterization of adult mouse meniscus stem/progenitor cells (2016)

Meniscal damage is a common problem that accelerates the onset of knee osteoarthritis. Stem cell-based tissue engineering treatment approaches have shown promise in preserving meniscal tissue and restoring meniscal function. The purpose of our study was to identify meniscus-derived stem/progenitor cells (MSPCs) from mouse, a model system that allows for in vivo analysis of the mechanisms underlying meniscal injury and healing. MSPCs were isolated from murine menisci grown in explant culture and characterized for stem cell properties. Flow cytometry was used to detect the presence of surface antigens related to stem cells, and qRT-PCR was used to examine the gene expression profile of MSPCs. Major proteins associated with MSPCs were localized in the adult mouse knee using immunohistochemistry. Our data show that MSPCs have universal stem cell-like properties including clonogenicity and multi-potentiality. MSPCs expressed the mesenchymal stem cell markers CD44, Sca-1, CD90, and CD73 and when cultured had elevated levels of biglycan and collagen type I, important extracellular matrix components of adult meniscus. MSPC also expressed significant levels of Lox and Igf-1, genes associated with the embryonic meniscus. Localization studies showed staining for these same proteins in the superficial and outer zones of the adult mouse meniscus, regions thought to harbor endogenous repair cells. MSPCs represent a novel resident stem cell population in the murine meniscus. Analysis of MSPCs in mice will allow for a greater understanding of the cell biology of the meniscus, essential information for enhancing therapeutic strategies for treating knee joint injury and disease.
High range resolution medical acoustic vascular imaging with frequency domain interferometry (2010)

For high range resolution acoustic vascular imaging we apply frequency domain interferometry and Capon method to a few frames of in-phase and quadrature (IQ) data acquired by a commercial ultrasonographic device. To suit the adaptive beamforming algorithm to medical acoustic imaging we employ three techniques; frequency averaging, whitening, and pseudo-double RF data conversion. The proposed method detected two couples of boundaries 0.26 and 0.19 mm apart using a single frame and two frames of IQ data, respectively, where each couple of boundaries is indistinguishable from a single boundary utilizing B-mode images. Further this algorithm could depict a swine femoral artery with higher range resolution than conventional B-mode imaging. These results indicate the potential of the proposed method for the range resolution improvement in ultrasonography, originating the progress in detection of vessel stenosis.
Container-Based Orchestration in Cloud: State of the Art and Challenges (2015)

How to effectively manage increasingly complex enterprise computing environments is one of the hardest challenges that most organizations have to face in the era of cloud computing, big data and IoT. Advanced automation and orchestration systems are the most valuable solutions helping IT staff to handle large-scale cloud data centers. Containers are the new revolution in the cloud computing world, they are more lightweight than VMs, and can radically decrease both the start up time of instances and the processing and storage overhead with respect to traditional VMs. The aim of this paper is to provide a comprehensive description of cloud orchestration approaches with containers, analyzing current research efforts, existing solutions and presenting issues and challenges facing this topic.
Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand. (2001)

Adenoviral chimeric tumor suppressor 1 (CTS1) gene transfer was evaluated as a novel approach of somatic gene therapy for malignant glioma. CTS1 is an artificial p53-based gene designed to resist various pathways of p53 inactivation. Here, we report that an adenovirus encoding CTS1 (Ad-CTS1) induces growth arrest and loss of viability in all glioma cell lines examined, in the absence of specific cell cycle changes. In contrast, an adenovirus encoding wild-type p53 (Ad-p53) does not consistently induce apoptosis in the same cell lines. Electron microscopic analysis of Ad-CTS1-infected glioma cells reveals complex cytoplasmic pathology and delayed apoptotic changes. Ad-CTS1 induces prominent activation of various p53 target genes, including p21 and MDM-2, but has no relevant effects on BCL-2 family protein expression. Although Ad-CTS1 strongly enhances CD95 expression at the cell surface, endogenous CD95/CD95 ligand interactions do not mediate CTS1-induced cell death. This is because Ad-CTS1 promotes neither caspase activation nor mitochondrial cytochrome c release and because the caspase inhibitors, z-val-Ala-DL-Asp-fluoromethylketone (zVAD)-fmk or z-Ile-Glu-Thr-Asp- fluoromethylketone (z-IETD)-fmk, do not block CTS1-induced cell death. Ad-CTS1 synergizes with radiotherapy and CD95 ligand in killing glioma cells. In summary, Ad-CTS1 induces an unusual type of cell death that appears to be independent of BCL-2 family proteins, cytochrome c release, and caspases. CTS1 gene transfer is a promising strategy of somatic gene therapy for malignant glioma.
Optimization strategy for liquid chromatography–electrospray ionization mass spectrometry methods (2000)

A strategy for the optimization of liquid chromatography (LC)–electrospray ionization mass spectrometry methods is proposed. The optimization aims at good chromatographic quality and a high signal-to-noise ratio for the analyte. The three-step strategy comprises screening experiments, LC studies and infusion experiments, using empirical modelling to evaluate the experimental data. The optimization route was examined for three different cases: (a) estriol in a mixture of estrogens, (b) ibuprofen and related metabolites in urine and (c) morphine in the presence of codeine.
Feature Extraction Based on K-Nearest Neighbor Decision Boundary (2007)

A modified K-nearest neighbor based decision boundary analysis(KNN-DBA)method is proposed for improving the classification performance.The decision boundary is determined by K-nearest neighbor classifier which is simple and fast.The extracted feature dimensionality is not limited by class number.Experimental results on the USPS handwritten digit dataset using nearest neighbor and support vector classifiers show that the DBA method outperforms principal component analysis(PCA).
Neutron imaging of inertial confinement fusion targets at Nova (1988)

Images of the neutron-emitting region of high-yield inertial confinement fusion targets have been obtained with a penumbral coded-aperture imaging system. The major components of the imaging system are the penumbral aperture, neutron detector, alignment hardware, and image reconstruction software. We describe these components and present an example of the neutron imaging results.
The Role of Surface Area and Compacity of Nanoparticles on the Rheology of Cement Paste 25.3 (2017)

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