gebhart/patrepeval huggingface dataset:
AMORPHOUS CELLULOSE - STRUCTURE AND CHARACTERIZATION (2011)

Amorphous cellulose was obtained from different types of celluloses (microcrystalline cellulose, dissolving pulp and cotton cellulose), by regeneration with ethanol from their solutions in an SO2-diethylaminedimethylsulfoxide (SO2-DEA-DMSO) solvent system. Different techniques, X-ray diffraction (XRD), FTIR spectroscopy and differential scanning calorimetry (DSC) were used to estimate the crystallinity degree. The values obtained for amorphous celluloses were compared with those of the initial samples and correlated with their supramolecular structures. Viscosity measurements have shown that little or no depolymerization occurs during dissolution.
Exercise hemodynamics in patients with COPD (2020)

<b>Background and Aims:</b> Pulmonary vascular disease is frequent in chronic obstructive pulmonary disease (COPD) and even patients with normal or mildly elevated mean pulmonary arterial pressure (mPAP) at rest may have abnormal exercise hemodynamics. Hence, we aimed to investigate pulmonary hemodynamics during exercise and its association with exercise capacity. <b>Patients and Methods:</b> Patients with COPD (mPAP&lt;25mmHg) and age and sex matched controls (at risk for pulmonary hypertension, but without relevant cardiopulmonary comorbidities and normal exercise capacity) underwent right heart catheterization at rest and during symptom limited ergometer exercise. Differences between the groups were analyzed with Kruskal-Wallis and Spearman9s rank correlation coefficient. <b>Results:</b> We enrolled n=26 patients (66±11yr, FEV1:56±25%) and compared them to n=26 controls. At rest, COPD patients had slightly higher mPAP (19(15-24) vs. 17(14-19) mmHg, p=0.022) and pulmonary vascular resistance (PVR) (2.6(1.4-3.0) vs. 1.7(1.1-2.2) WU, p=0.025). COPD patients reached lower maximum work load (50(50-100) vs. 100(75-125)W, p=0.002) and reduced peak oxygen uptake (VO2) (64(48-80) vs. 96(88-102) %predicted, p&lt;0.001) during exercise and revealed higher mPAP/cardiac output (CO) slope (6.7(3.5-7.7) vs. 3.3(2.1-4.4) mmHg/L/min, p=0.015), RAP/CO slope (1.9(0.6-3.0) vs. 1.1(0.5-1.9) mmHg/L/min, p=0.045) and (mPAP-PAWP)/CO slope (3.3(1.2-4.3) vs. 1.3(0.9-2.9) mmHg/L/min, p=0.031). In addition, peakVO2 was inversely correlated with mPAP (r=-0.513, p=0.004) and PVR (r=-0.547, p=0.003) at peak exercise. <b>Conclusion:</b> Pulmonary hemodynamics during exercise show characteristic changes in COPD and may contribute to exercise limitation. Validation of these data in larger cohorts is warranted.
Path-protecting p -cycles and the protected working capacity envelope concept: addressing the needs of dynamic transparent optical networks (2005)

Two important aspects of optical networking are to ensure transmission integrity when connecting optically transparent channels in real time for protection, and the handling of dynamic demand, especially when survivability considerations are added. The prevalent approach for providing protected dynamic lightpath services is signaling intensive, database dependent, and requires on-the-fly cross-connection of standby lightwave channels to form protection paths. With two inter-related new concepts, we address concerns about on-the-fly concatenation of transparent optical channels to form protection paths and improve the scalability, and reduce database dependence and signalling intensity associated with current methods. An extension of the <i>p</i>-cycles concept to end-to-end path protection, in conjunction with the concept of a protected working capacity envelope for dynamic provisioning (which has no per-connection signaling for backup path establishment) yields a highly efficient network architecture in which protection paths are fully pre-cross-connected prior to failure and only the two lightpath end-nodes need to detect path failure and switch the lightpath (or its traffic) into a corresponding pre-planned path-protecting <i>p</i>-cycle.
Learning Depth from Single Monocular Images (2005)

We consider the task of depth estimation from a single monocular image. We take a supervised learning approach to this problem, in which we begin by collecting a training set of monocular images (of unstructured outdoor environments which include forests, trees, buildings, etc.) and their corresponding ground-truth depthmaps. Then, we apply supervised learning to predict the depthmap as a function of the image. Depth estimation is a challenging problem, since local features alone are insufficient to estimate depth at a point, and one needs to consider the global context of the image. Our model uses a discriminatively-trained Markov Random Field (MRF) that incorporates multiscale local- and global-image features, and models both depths at individual points as well as the relation between depths at different points. We show that, even on unstructured scenes, our algorithm is frequently able to recover fairly accurate depthmaps. 1
INOSITOL‐1,4,5‐TRISPHOSPHATE [INS(1,4,5)P3] AND INS(1,4,5)P3 RECEPTOR CONCENTRATIONS IN HEART TISSUES (1994)

1. The isolation and culture of neonatal cardiomyocytes causes changes in the metabolism of inositol(1,4,5) trisphosphate (Ins(1,4,5)P3) from primarily dephosphorylation in the intact tissue to a combination of phosphorylation and dephosphorylation in the cultured cells (Woodcock et al. 1992). 2. The content of Ins(1,4,5)P3 was found to be higher in intact heart tissue than in the isolated neonatal cells (10.9 +/- 1.3 and 0.5 +/- 0.1 pmol/mg tissue, mean +/- s.e.m., n = 4, P < 0.002, respectively). 3. Despite this difference, Ins(1,4,5)P3 receptors in intact tissue and in isolated cells were not different in terms of affinity (8.0 +/- 1.7 and 10.9 +/- 1.6 nmol/L, n = 3, respectively) or concentration (143.3 +/- 20.5 and 91.2 +/- 16.0 fmol/mg protein, n = 3, respectively). 4. Thus, while there appears to be a relationship between the tissue content of Ins(1,4,5)P3 and its metabolism, no relationship to the properties of Ins(1,4,5)P3 receptors could be demonstrated.
QINGDAI (QD) FOR PATIENTS WITH ACTIVE ULCERATIVE COLITIS: A RETROSPECTIVE ISRAELI NATIONAL EXPERIENCE (2023)

Abstract BACKGROUND QingDai (QD, Indigo) was shown to be effective for ulcerative colitis (UC) in randomized controlled trials and retrospective reports from Japan. However, experience with QD for UC in the West is extremely limited. We aimed to describe the effectiveness and safety of QD in a national cohort of patients with UC followed at tertiary referral centers in Israel. METHODS A retrospective study. We included adult patients who received QD for active UC (simple colitis clinical activity index (SCCAI)≥3) between 2018 -2022 at five academic centers. A majority of patients received QD in a combination with curcumin (CurQD). The primary outcome was clinical response at the end of induction (defined as the last follow-up visit between weeks 8 to 16 from the start of the treatment). Clinical response was defined as an improvement of SCCAI≥ 3 points; clinical remission as SCCAI≤2. C-reactive protein (CRP), fecal calprotectin (FC) levels and endoscopic Mayo score before and after treatment were compared when available. Starting corticosteroid or biologic treatment, hospitalization due to disease exacerbation, colectomy, discontinuation of treatment due to an adverse event or missing follow-up data were considered treatment failures RESULTS A total of 82 patients were included [median age-32, interquartile ratio (IQR)-23-41), 47 (57.3%) female; disease extent- 16 (20.5%)-proctitis, 28 (35.9%)- left-sided, 34 (43.6%) – pancolitis]. At treatment onset, 27 (41.5%) were treated with corticosteroids and 28 (34.1%) with a biologic or small molecule, 10 (12.9%) failed ≥ 3 biologics or small molecules. Median SCCAI was 6 (5-9), CRP- 5 (2-17) mg/L, fecal calprotectin levels – 698 (320 -1190) mg/g and endoscopic Mayo score- 2. QD was initiated in combination with curcumin (CurQD) in 77 (95.1%) of the patients. The last induction follow-up occurred after a median of 8 (8-12) weeks. At the end of induction, 64 (78%) responded to treatment, including 52 (63.4%) that achieved clinical remission (figure 1). At the end of induction, median SCCAI was 2 (1-3) (p&amp;lt;0.001), CRP- 2 (1-5) mg/L (p=0.003, 22 patients with paired measurements), FC levels -75 (12-139, 35 patients) mg/g (p&amp;lt;0.001, Figure 2) and median endoscopic Mayo score -1 (0-2) (p=0.03, 12 patients). Two (2.3%) patients experienced headaches and 5 (6.1%) mild liver function elevations that resolved spontaneously or following QD discontinuation (2 patients). CONCLUSIONS In this multicenter retrospective cohort study, QD treatment (predominantly as combination CurQD) was effective for induction of clinical response and remission in active UC patients, including biologic-experienced patients. All adverse events were mild and resolved either spontaneously or after QD discontinuation. Our results suggest QD as a potential effective and safe agent for induction of response and remission in patients with active UC.
Using all signed-digit representations to design single integer multipliers using subexpression elimination (2004)

A new algorithm is introduced for design of integer multipliers using subexpression elimination. Hartley's algorithm for subexpression elimination is applied to all possible signed-digit representations of the integer. Results are within 1% of the slow optimal exhaustive searches for 19-bit integers.
Toward an understanding of the impact of software personal assistants on human organizations (2006)

Intelligent software personal assistants for human organizations are an active research area within the multiagent community. However, while many capabilities for these software personal assistants are imagined or already developed, there has been no quantification of how an organization's performance is improved by software personal assistants. Moreover, while intuitively organizations will adapt to take advantage of the new technology, there has been no work looking at how organizations should or will change in response to the new technology. This paper presents a first step toward addressing this oversight. Specifically, a computational model of the working of an organization and how software personal assistants will affect that organization is developed that allows effects of software personal assistants to be modeled. By varying the potential capabilities of the software personal assistants and the structure of the organization, we can explore the impact of the technology. Our results show that managing task contingencies can greatly improve organizational performance by as much as 45%.
A power-efficient migration mechanism for D-NUCA caches (2009)

D-NUCA L2 caches are able to tolerate the increasing wire delay effects due to technology scaling thanks to their banked organization, broadcast line search and data promotion/demotion mechanism. Data promotion mechanism aims at moving frequently accessed data near the core, but causes additional accesses on cache banks, hence increasing dynamic energy consumption. We shown how, in some cases, this migration mechanism is not successful in reducing data access latency and can be selectively and dynamically inhibited, thus reducing dynamic energy consumption without affecting performances.
Amphotericin B O-methyl oxime Synthesis and biological properties. (1990)

Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity.
Throttle and preempt: a new flow control for real-time communications in wormhole networks (2002)

We study wormhole routed networks and their suitability for real-time traffic in a priority-driven paradigm. A traditional blocking flow control in wormhole routing may lead to a priority inversion in the sense that high priority packets are blocked by low priority packets for unlimited time. This uncontrolled priority inversion causes the frequent deadline missing. This paper therefore proposes a new flow control called throttle and preempt flow control, where high priority packets can preempt network resources held by low priority packets, if necessary. As a result, this flow control does not cause priority inversion. Our simulations show that the throttle and preempt flow control dramatically reduces deadline miss ratio without extra virtual channels. It is also observed that the throttle and preempt flow control offers shorter delay for non-real-time traffic than existing real-time flow control does.
A “Greenhouse Gas” Experiment for the Undergraduate Laboratory (2014)

This experiment and analysis offer an effective experience in greenhouse gas reduction. Ammoniated water is flowed counter-current to a simulated flue gas of air and CO2 in a packed column. The gaseous CO2 concentrations are measured with an on-line, non- dispersive, infrared analyzer. Column operating parameters include total gas flux, dissolved NH3 concentration, liquid flux, and inlet CO2 partial pressure. The CO2 capture efficiency is correlated using a kinetic model with a dimensionless Stanton number and a mass transfer coefficient.
Revisiting the guidelines for ending isolation for COVID-19 patients (2021)

Since the start of the COVID-19 pandemic, two mainstream guidelines for defining when to end the isolation of SARS-CoV-2-infected individuals have been in use: the one-size-fits-all approach (i.e. patients are isolated for a fixed number of days) and the personalized approach (i.e. based on repeated testing of isolated patients). We use a mathematical framework to model within-host viral dynamics and test different criteria for ending isolation. By considering a fixed time of 10 days since symptom onset as the criterion for ending isolation, we estimated that the risk of releasing an individual who is still infectious is low (0-6.6%). However, this policy entails lengthy unnecessary isolations (4.8-8.3 days). In contrast, by using a personalized strategy, similar low risks can be reached with shorter prolonged isolations. The obtained findings provide a scientific rationale for policies on ending the isolation of SARS-CoV-2-infected individuals.
Role of sulA and sulB in filamentation by lon mutants of Escherichia coli K-12 (1981)

Cells containing the pleiotropic Escherichia coli mutation lon filament extensively and die after exposure to ultraviolet light. Outside suppressors of the ultraviolet sensitivity, called sul, have previously been described at two loci; these mutations reverse the ultraviolet sensitivity of lon strains but do not affect the mucoidal or degradation defect of these strains. An isogenic set of strains carrying combinations of lon, sulA, and sulI was constructed, and their behavior during normal growth and after ultraviolet treatment was studied. sulA mutations had no detectable phenotype in lon+ cells; the lon sulA strains filamented transiently after ultraviolet irradiation, as did lon+ sul+ cells. We found that the sulB mutation, which alters cell morphology and slows recovery from transient filamentation after ultraviolet treatment, was epistatic to both lon and sulA. Whereas sulA mutations were recessive to the wild-type allele, sulB was partially dominant. The simplest model to account for our observations is that sulA and lon participate in a pathway of filamentation independent of that which produces transient filamentation in wild-type strains; sulB product may be the target of sulA action and may play a role in normal cell division.
Erratum: ’’Effect of diffraction on stress pulse propagation’’ [ J. Acoust. Soc. Am. 64, 1692−1699 (1978)] (1979)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. R. Layton, E. F. Carome, H. D. Dardy, J. A. Bucaro; Erratum: ''Effect of diffraction on stress pulse propagation'' [ J. Acoust. Soc. Am. 64, 1692−1699 (1978)]. J. Acoust. Soc. Am. 1 May 1979; 65 (5): 1342. https://doi.org/10.1121/1.382935 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Detection of differentially expressed genes involved in osteoarthritis pathology (2018)

TWIST1, POU2F1, SMARCA4, and CREBBP may play an important role in OA pathology.
Pneumococcal Pericarditis (1986)

Although counterimmunoelectrophoresis (CIE) analysis of cerebrospinal fluid has proved useful in the diagnosis of meningitis, there has been little experience with its use in analyzing pericardial fluid. We describe two patients with pneumococcal pneumonia whose hospital course was complicated by purulent pericarditis. In one patient, results of a computed tomographic scan were important in suggesting the diagnosis. Results of a Gram's stain and culture of pericardial fluid failed to yield any organisms, presumably because both patients had received nine days of beta-lactam antibiotic therapy. However, the results from CIE analysis of pericardial fluid in both cases were positive for Streptococcus pneumoniae. In one patient, for whom capsular typing of the organism was performed, the pneumococcus type isolated from pericardial fluid matched the type isolated previously from a blood sample. The results of CIE can allow focused antibiotic therapy by establishing the correct diagnosis.
The case for establishing a board of review for resolving environmental issues: The science court in Canada (2015)

Technology and scientific advancements are accelerating changes in society at a pace that is challenging the abilities of government regulatory agencies and legal courts to understand the benefits and costs of these changes to humans, wildlife, and their environments. The social, economic, and political facets of concern, such as the potential effects of chemicals, complicate the preparation of regulatory standards and practices intended to safeguard the public. Court judges and attorneys and, in some cases, lay juries are tasked with interpreting the data and implications underlying these new advancements, often without the technical background necessary to understand complex subjects and subsequently make informed decisions. Here, we describe the scientific-quasi-judicial process adopted in Canada under the Canadian Environmental Protection Act, 1999, which could serve as a model for resolving conflicts between regulatory agencies and the regulated community. An example and process and lessons learned from the first Board of Review, which was for decamethylcyclopentasiloxane (D5; CAS# 541-02-06), are provided. Notable among these lessons are: 1) the need to apply state-of-the-science insights into the regulatory process, 2) to encourage agencies to continuously review and update their assessment processes, criteria, and models, and 3) provide these processes in guidance documents that are transparent and available to all stakeholders and generally foster closer cooperation between regulators, the academic community, industry, and nongovernment organizations (NGOs). Integr Environ Assess Manag 2016;12:572-579. © 2015 SETAC.
Pyrimidinylhydrazones, a new class of fungicides. (1986)

(la) of 2-pyrimidinylhydrazones surfaced in our random fungicidal screening program. Chemical manipulation of the pointer we stumbled upon has led to a new class of potential fungicides with high efficacy and without structural relations to marketed antifungals.
Deficiency in Inducible Nitric Oxide Synthase Protects Mice from Ozone-Induced Lung Inflammation and Tissue Injury (2002)

Inhalation of ozone causes Type I epithelial cell necrosis and Type II cell hyperplasia and proliferation. This is associated with an accumulation of activated macrophages in the lower lung, which we have demonstrated contribute to tissue injury. Nitric oxide (NO) is a highly reactive cytotoxic macrophage-derived mediator that has been implicated in lung damage. In the present studies we used knockout mice with a targeted disruption of the gene for inducible nitric oxide synthase (NOSII) to analyze the role of NO in ozone-induced lung inflammation and tissue injury. Treatment of wild-type control mice with ozone (0.8 ppm) for 3 h resulted in a time-dependent increase in protein and cells in bronchoalveolar lavage fluid, which reached a maximum 24-48 h after exposure. Alveolar macrophages isolated from animals treated with ozone were found to produce increased amounts of NO, as well as peroxynitrite. This was correlated with induction of NOSII protein and nitrotyrosine staining of lung macrophages in tissue sections and in culture. Production of superoxide anion and prostaglandin (PG)E2 by alveolar macrophages was also increased after ozone inhalation. In contrast, alveolar macrophages from NOSII knockout mice did not produce reactive nitrogen intermediates even after ozone inhalation. Moreover, production of PGE2 was at control levels. NOSII knockout mice were also protected from ozone-induced inflammation and tissue injury, as measured by bronchoalveolar lavage protein and cell number. There was also no evidence of peroxynitrite-mediated lung damage in these animals. Taken together, these data demonstrate that NO, produced via NOSII, and potentially, its reactive oxidative product peroxynitrite, play a critical role in ozone-induced release of inflammatory mediators and in tissue injury.
Synthesis of Racemic cis- and trans-3-Phenylazetidine-2-Carboxylic Acids as Conformationally Restricted Analogs of Phenylalanine (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Racemic cis- and trans-3-Phenylazetidine-2-Carboxylic Acids as Conformationally Restricted Analogs of PhenylalanineDavid J. Blythin, Michael J. Green, Mary Jane R. Lauzon, and Ho-Jane ShueCite this: J. Org. Chem. 1994, 59, 20, 6098–6100Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jo00099a050https://doi.org/10.1021/jo00099a050research-articleACS PublicationsRequest reuse permissionsArticle Views324Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts