gebhart/patrepeval huggingface dataset:
Radiometric compensation algorithm for color reproduction of projection display on patterned surface (2010)

A novel radiometric compensation algorithm is proposed to correct the color distortions of the projection display on patterned surface. Two choices of the objective image are investigated in this algorithm. A linear compression followed by a sigmoid-function transformation based on the statistical parameters of the compensating radiance map is performed to reduce the clippings of the compensating color and expected to properly reproduce the dynamic range and the visibility of the image content. Three types of projection displays are produced for each test image. The parameter analysis indicates that the compensated displays could well conceal the surface pattern and tend to exhibit higher lightness or lightness contrast in the camera. The comparison results in a psychophysical experiment demonstrate that all the compensated displays outperform the uncompensated ones. The original input images seem more appropriate to be selected as the objective images, and the predicted objectives on the white screen are just proper for the bright and low-contrast input images displayed on the faint surface.
Florida Rainfall Data Sources and Types (2017)

This new 5-page document introduces the sources, providers, and types of rainfall data available to Florida researchers and residents to promote understanding of the rainfall data and their application in studies and daily life. Written by Meijing Zhang, Young Gu Her, Kati Migliaccio, and Clyde Fraisse, and published by the UF Department of Agricultural and Biological Engineering, January 2017. AE517/AE517: Florida Rainfall Data Sources and Types (ufl.edu)
Data from Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human <i>PD-1xLAG-3</i>–Knockin Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;In the tumor microenvironment, multiple inhibitory checkpoint receptors can suppress T-cell function, thereby enabling tumor immune evasion. Blockade of one of these checkpoint receptors, PD-1, with therapeutic antibodies has produced positive clinical responses in various cancers; however, the efficacy of this approach can be further improved. Simultaneously targeting multiple inhibitory checkpoint receptors has emerged as a promising therapeutic strategy. Here, we report the development and characterization of REGN3767, a fully human IgG4 antibody targeting LAG-3, another inhibitory receptor on T cells. REGN3767 binds human and monkey LAG-3 with high affinity and specificity and blocks the interaction of LAG-3 with its ligand, MHC class II. In an engineered T-cell/antigen-presenting cell bioassay, REGN3767 alone, or in combination with cemiplimab (REGN2810, human anti-PD-1 antibody), blocked inhibitory signaling to T cells mediated by hLAG-3/MHCII in the presence of PD-1/PD-L1. To test the &lt;i&gt;in vivo&lt;/i&gt; activity of REGN3767 alone or in combination with cemiplimab, we generated human &lt;i&gt;PD-1xLAG-3&lt;/i&gt; knockin mice, in which the extracellular domains of mouse &lt;i&gt;Pdcd1&lt;/i&gt; and &lt;i&gt;Lag3&lt;/i&gt; were replaced with their human counterparts. In these humanized mice, treatment with cemiplimab and REGN3767 showed increased efficacy in a mouse tumor model and enhanced the secretion of proinflammatory cytokines by tumor-specific T cells. The favorable pharmacokinetics and toxicology of REGN3767 in nonhuman primates, together with enhancement of antitumor efficacy of anti-PD-1 antibody in preclinical tumor models, support its clinical development.&lt;/p&gt;&lt;/div&gt;
High-density interconnect board design for wafer-level packaging (2011)

The main advantage of wafer-level packaging is a smaller, thinner and lighter package with minimised electrical length and lower inductance. Presented is a printed circuit board electrical design to assemble a wafer-level package of a wireless radio core. The link impact and challenges are addressed in both time domain and frequency domain. The high-density interconnect substrate is analysed using a design of experiment technique to test the significance of structured variation. Its signal integrity and power delivery performance are compared with a similar design, but much thicker using a flip-chip package mounted on top of the conventional board. The thin board for wafer-level packaging provides better power delivery and signal performance than the traditional assembly.
A Close-up View of the VraSR Two-component System (2008)

Staphylococcus aureus remains a clinical scourge. Recent studies have revealed that S. aureus is capable of mounting a response to antibiotics that target cell wall peptidoglycan biosynthesis, such as beta-lactams and vancomycin. A phosphotransfer-mediated signaling pathway composed of a histidine protein kinase, VraS, and a response regulator protein, VraR, has been linked to the coordination of this response. Herein, we report for the first time on the signal transduction mechanism of the VraSR system. We found that VraS is capable of undergoing autophosphorylation in vitro and its phosphoryl group is rapidly transferred to VraR. In addition, phosphorylated VraR undergoes rapid dephosphorylation by VraS. Evidence is presented that VraR has adopted a novel strategy in regulating the output response of the VraSR-mediated signaling pathway. The VraR effector domain inhibits formation of inactive VraR dimers and, in doing so, it holds the regulatory domain into an intermediate active state. We show that only phosphorylation induces formation of the biological active VraR-dimer species. Furthermore, we propose that damage inflicted to cell wall peptidoglycan could be the main source of the stimuli that VraR responds to due to the tight control that VraS has on the phosphorylation state of VraR. Our findings provide for the first time insights into the molecular basis for the proposed role of VraSR as a "sentinel" system capable of rapidly sensing cell wall peptidoglycan damage and coordinating a response that enhances the resistance phenotype in S. aureus.
Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2 (1990)

Neuroblastoma cells maintained in serum-free medium exhibit a significant induction of MAP-1a and Tau proteins, but not MAP-2; the time course of these inductions is highly correlated with an increase in microtubule mass which parallels neurite growth. Bovine brain gangliosides (BBG) enhance the neurite outgrowth response of these cells. We report here that one effect of gangliosides is the selective and dramatic induction of MAP-2 expression. Our results also indicate a strong parallelism between this induction and the increase in microtubule mass which accompanies the appearance of more numerous, longer, and highly branched neurites. These observations suggest that MAP-2 induction in neuroblastoma cells may lead to a further differentiation of neurites equivalent to that observed in mature brain neurons. Finally, our results indicate that gangliosides per se are not neuritogenic factors but rather substances capable of enhancing cell-derived influences which affect the neurite outgrowth response of neuroblastoma cells and the type of MAP that they express.
Cha-Cha: a system for organizing intranet search results (1999)

... recently received much academic and commercial attention, surprisingly little research has been done with the internal workings of an organization. A standard search engine retrieves web pages that fall within a widely diverse range of information contexts, but presents these results uniformly, in a ranked list. As an alternative, the Cha-Cha system organizes web search results in such a way as to reect the underlying structure of the intranet. In our approach, an &amp;quot;outline&amp;quot; or &amp;quot;table of contents&amp;quot; is created by rst recording the shortest paths in hyperlinks from root pages to every page within the web intranet. After the user issues a query, these shortest paths are dynamically combined to form a hierarchical outline of the context in which the search results occur. The system is designed to be helpful for users with a wide range of computer skills. Preliminary user study and survey results suggest that some users nd the resulting structure more helpful than the standard retrieval results display for intranet search.
ChemInform Abstract: Cs5(Na(W4N10)): The First Framework Nitridotungstate(VI). (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates. (1984)

Lysyl oxidase initiates the covalent cross-linking of elastin and collagen by oxidizing lysine residues in these proteins to alpha-aminoadipic-delta-semialdehyde. Sequences surrounding susceptible lysines in elastin are considerably different from those in collagen and yet the same enzyme can oxidize both substrates. Possible bases of the specificity have been explored assaying for H2O2 release accompanying the oxidation of synthetic peptide and protein substrates. Rates of oxidation of random co-polymers were maximal with (Ala,Lys)n and decreased in the order (Val,Lys)n greater than (Leu,Lys)n greater than (Lys)n greater than (Phe,Lys)n greater than (Tyr,Lys)n. The ordered polymer (Ala-Lys-Glu)n was oxidized at only 3% of the rate of (Ala,Lys)n, implying inhibition by peptidyl glutamate. Consistent with this conclusion, kinetic analyses using ordered oligopeptides revealed that, relative to Ala-Ala-Lys-Ala-Ala, Km is increased 9.3-fold for lysine in Ala-Ala-Lys-Glu-Ala-Ala, 2.5-fold in Ala-Ala-Lys-Arg-Ala-Ala, and 1.8-fold in Ala-Ala-Glu-Lys-Ala-Ala. Tyrosine C-terminal to lysine in such peptides also increases Km 5-fold. In addition, lysyl oxidase oxidized lysine in various proteins with basic isoelectric points and was much less or not active against various acidic proteins. Lysyl oxidase was inactive against native bovine serum albumin but effectively oxidized albumin if albumin carboxyl functions were first amidated by chemical modification. These results suggest that peptides bind to lysyl oxidase in a preferred directional sense and indicate-that net anionic character as well as the specific position of anionic residues in substrates can selectively effect substrate potential. Implications of these results for the oxidation of elastin and collagen are discussed.
What Does It Take To Make a Stable POSS®/Polymer Composite? (2010)

Polycarbonate (PC) and phenoxy resin have similar structures derived from bisphenol-A. Phenoxy resin possesses pendant hydroxyl groups along its backbone; instead of the carbonate carbonyls groups found in polycarbonate. This difference in structure significantly influences thermo-mechanical properties when these materials are blended with TPOSS, phenyl trisilanol polyhedral oligomeric silsesquioxanes. Composites of TPOSS with PC and with phenoxy resin were produced and characterized. The TPOSS was highly soluble in polycarbonate, interacted with phenyl groups in the polymer at a hierarchical level such that ring flipping motions were retarded, but individual bonds within the phenyl rings were not affected. The net result of this level of interaction was that TPOSS served as an antiplasticizer for polycarbonate. The TPOSS was also reasonably compatible with phenoxy resin, but exhibited considerable interactions with the polymer on a molecular level. The hydroxyl group on the phenoxy polymer was observed to hydrogen bond to the POSS silanol groups, and the phenyl groups in the polymer π-stacked with POSS-bound phenyls. With this two-fold binding between polymer and filler, a level of thermo/mechanical reinforcement was achieved; the suggested two-point binding can be thought of as a reversible, “supramolecular” grafting.
Tumor cell distribution following laparoscopic colectomy in a porcine model (1996)

These results demonstrate application of the porcine model to test current surgical practices and measures that might be used perioperatively to reduce the numbers of intraperitoneal tumor cells or their distribution to specific sites during laparoscopic or open surgery.
Opening Pandora's box through ATFuzzer (2019)

This paper focuses on checking the correctness and robustness of the AT command interface exposed by the cellular baseband processor through Bluetooth and USB. A device's application processor uses this interface for issuing high-level commands (or, AT commands) to the baseband processor for performing cellular network operations (e.g., placing a phone call). Vulnerabilities in this interface can be leveraged by malicious Bluetooth peripherals to launch pernicious attacks including DoS and privacy attacks. To identify such vulnerabilities, we propose ATFuzzer that uses a grammar-guided evolutionary fuzzing approach which mutates production rules of the AT command grammar instead of concrete AT commands. Empirical evaluation with ATFuzzer on 10 Android smartphones from 6 vendors revealed 4 invalid AT command grammars over Bluetooth and 13 over USB with implications ranging from DoS, downgrade of cellular protocol version (e.g., from 4G to 3G/2G) to severe privacy leaks. The vulnerabilities along with the invalid AT command grammars were responsibly disclosed to affected vendors and two of the reported vulnerabilities have been already assigned CVEs (CVE-2019-16400 and CVE-2019-16401).
Electrospun Hollow Glassy Carbon-Reduced Graphene Oxide Nanofibers with Encapsulated ZnO Nanoparticles : A Free-Standing Anode for Li-Ion Batteries (2015)

Although zinc oxide (ZnO) has a high theoretical capacity for lithium storage, its poor cyclability due to the huge volume changes during charge–discharge cycles result in particle pulverization and detachment from the current collector. In this work, a novel anode architecture for Li-ion batteries is fabricated by encapsulating ZnO nanoparticles in the hollow core of glassy carbon–reduced graphene oxide (C–rGO) electrospun composite nanofibers. A one-step, co-axial electrospinning method is used to synthesize a mat of core–shell structured composite nanofibers composed of rGO embedded in poly(acrylonitrile) (shell) and a ZnO nanoparticle precursor with a carrier polymer (core). Subsequent calcination and carbonization produce a mechanically stable anode material, which is used directly as a free-standing anode without any binder and current collector. The ZnO–C–rGO nanofiber composite was characterized by SEM, TEM, RAMAN and XRD techniques. The electrochemical performance of the composite was studied by galvanostatic charge–discharge measurements at different current densities, slow scan cyclic voltammetry (CV) and impedance measurements. Incorporation of an rGO network in the glassy nanofiber shell enhances both the capacity and electrical conductivity of the mat electrode resulting in faster electron kinetics, and thus, an improved rate capability. The interior void spaces combined with the mechanical strength and flexibility of the C–rGO shell act as a structural buffer effectively relieving the volumetric stresses generated during charge–discharge cycles. The synergistic effect of the metal oxide, rGO and the core–shell design results in a high capacity of 815mAh/g at a current density of 50mA/g with a capacity retention of almost 80% after 100 cycles, thus demonstrating significant potential as an anode substitute for next generation Li-ion batteries.
Data from Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Hallmarks of germline &lt;i&gt;BRCA1/2&lt;/i&gt;-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic &lt;i&gt;BRCA1/2&lt;/i&gt; mutations and mutations in other homologous recombination DNA repair genes is uncertain.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Using targeted capture and massively parallel genomic sequencing, we assessed 390 ovarian carcinomas for germline and somatic loss-of-function mutations in 30 genes, including &lt;i&gt;BRCA1&lt;/i&gt;, &lt;i&gt;BRCA2&lt;/i&gt;, and 11 other genes in the homologous recombination pathway.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: &lt;i&gt;BRCA1&lt;/i&gt;, &lt;i&gt;BRCA2&lt;/i&gt;, &lt;i&gt;ATM&lt;/i&gt;, &lt;i&gt;BARD1&lt;/i&gt;, &lt;i&gt;BRIP1&lt;/i&gt;, &lt;i&gt;CHEK1&lt;/i&gt;, &lt;i&gt;CHEK2&lt;/i&gt;, &lt;i&gt;FAM175A&lt;/i&gt;, &lt;i&gt;MRE11A&lt;/i&gt;, &lt;i&gt;NBN, PALB2&lt;/i&gt;, &lt;i&gt;RAD51C&lt;/i&gt;, and &lt;i&gt;RAD51D&lt;/i&gt;. Nonserous ovarian carcinomas had similar rates of homologous recombination mutations to serous carcinomas (28% vs. 31%, &lt;i&gt;P&lt;/i&gt; = 0.6), including clear cell, endometrioid, and carcinosarcoma. The presence of germline and somatic homologous recombination mutations was highly predictive of primary platinum sensitivity (&lt;i&gt;P&lt;/i&gt; = 0.0002) and improved overall survival (&lt;i&gt;P&lt;/i&gt; = 0.0006), with a median overall survival of 66 months in germline homologous recombination mutation carriers, 59 months in cases with a somatic homologous recombination mutation, and 41 months for cases without a homologous recombination mutation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Germline or somatic mutations in homologous recombination genes are present in almost one third of ovarian carcinomas, including both serous and nonserous histologies. Somatic &lt;i&gt;BRCA1/2&lt;/i&gt; mutations and mutations in other homologous recombination genes have a similar positive impact on overall survival and platinum responsiveness as germline &lt;i&gt;BRCA1/2&lt;/i&gt; mutations. The similar rate of homologous recombination mutations in nonserous carcinomas supports their inclusion in PARP inhibitor clinical trials. &lt;i&gt;Clin Cancer Res; 20(3); 764–75. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Analysis of Glycans on Serum Proteins Using Antibody Microarrays (2009)

Antibody arrays can be employed for the profiling glycan structures on proteins. Antibody arrays capture multiple, specific proteins directly from biological samples (such as serum), and lectin and glycan-binding antibodies probe the levels of specific glycans on the captured proteins. We use a practical method of partitioning microscope slides to enable the convenient processing of many detection reagents or samples. A critical first step in the procedure is the chemical derivatization of the glycans on the spotted capture antibodies, which prevents lectin binding to those glycans. We describe those methods along with the methods for preparing and treating serum samples, running the experiments, and designing and interpreting the experiments.
Makef15: An ADCIRC Model Fort.15 Input File Creation GUI for Parameter Specification and Periodic Boundary Forcing (2007)

Abstract : The User's Manual for the Makef15 Graphical User Interface (GUI) software, makefort15gui.pl, contains descriptions of the software, including its functionality and usage. The Makef15 GUI is a window-based, platform-independent Perl script that can both create or modify the ADvanced CIRCulation (ADCIRC) Model Parameter and Periodic Boundary Forcing File (fort.15). The software was developed for ADCIRC versions 45.11.
Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex (2016)

RNA virus infections are detected by the RIG-I family of receptors, which signal through the adaptor molecule mitochondrial antiviral signaling (MAVS). MAVS then recruits the adaptor's tumor necrosis factor receptor-associated factor (TRAF) 3 and TRAF6, which in turn activate IRF3 and NF-κB, respectively, to induce interferons (IFNs) and inflammatory responses. Here we show that the biotin-containing enzyme methylcrotonoyl-CoA carboxylase 1 (MCCC1) enhances virus-induced, MAVS-mediated IFN and inflammatory cytokine expression through the NF-κB signaling pathway. MCCC1 knockdown strongly inhibits induction of IFNs and inflammatory cytokines. Furthermore, MCCC1 shows extensive antiviral activity toward RNA viruses, including influenza A virus, human enterovirus 71, and vesicular stomatitis virus. Here, we have elucidated the mechanism underlying MCCC1-mediated inhibition of viral replication. MCCC1 interacts with MAVS and components of the MAVS signalosome and contributes to enhanced production of type I IFNs and pro-inflammatory cytokines by promoting phosphorylation of the IκB kinase (IKK) complex and NF-κB inhibitor-α (IκBα), as well as NF-κB nuclear translocation. This process leads to activation of IFNs and cytokine expression and subsequent activation of IFN-stimulated genes, including double-stranded RNA-dependent protein kinase PKR and myxovirus resistance protein 1. These findings demonstrate that MCCC1 plays an essential role in virus-triggered, MAVS-mediated activation of NF-κB signaling.
Organizational Learning Culture, Social Exchange Relations and Multifoci Citizenship Behaviors: A Literature Survey Approach (2013)

2 Abstract: The present study is an attempt to seek the relationship among organizational learning culture, social exchange and extra role behaviors (i.e. organizational citizenship behaviors). The construct organizational learning culture has not been explored extensively by the studies especially in the context of social exchange relations. But still good amount of literature have been discussed to see the true picture. Literature has confirmed that there are three types of exchange relations i.e. organization-employee, employee-employee and supervisors-employee. Organizational learning culture influences on organization- employee and employee- employee exchange relations. Which further promote learning culture in organizations.