gebhart/patrepeval huggingface dataset:
Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling (2017)

Erythro-myeloid progenitors (EMPs) were recently described to arise from the yolk sac endothelium, just prior to vascular remodeling, and are the source of adult/post-natal tissue resident macrophages. Questions remain, however, concerning whether EMPs differentiate directly from the endothelium or merely pass through. We provide the first evidence in vivo that EMPs can emerge directly from endothelial cells (ECs) and demonstrate a role for these cells in vascular development. We find that EMPs express most EC markers but late EMPs and EMP-derived cells do not take up acetylated low-density lipoprotein (AcLDL), as ECs do. When the endothelium is labelled with AcLDL before EMPs differentiate, EMPs and EMP-derived cells arise that are AcLDL<sup>+</sup>. If AcLDL is injected after the onset of EMP differentiation, however, the majority of EMP-derived cells are not double labelled. We find that cell division precedes entry of EMPs into circulation, and that blood flow facilitates the transition of EMPs from the endothelium into circulation in a nitric oxide-dependent manner. In gain-of-function studies, we inject the CSF1-Fc ligand in embryos and found that this increases the number of CSF1R<sup>+</sup> cells, which localize to the venous plexus and significantly disrupt venous remodeling. This is the first study to definitively establish that EMPs arise from the endothelium in vivo and show a role for early myeloid cells in vascular development.
Routing-based source-location privacy protection in wireless sensor networks (2009)

Wireless sensor networks (WSN) have the potential to be widely used in many areas for unattended event monitoring. Mainly due to lack of a protected physical boundary, wireless communications are vulnerable to unauthorized interception and detection. Privacy is becoming one of the major issues that jeopardize the successful deployment of wireless sensor networks. While confidentiality of the message can be ensured through content encryption, it is much more difficult to adequately address the source-location privacy. For WSN, source-location privacy service is further complicated by the fact that the sensor nodes consist of low-cost and low-power radio devices. Therefore, computationally intensive cryptographic algorithms (such as public-key cryptosystems) and large scale broadcasting-based protocols are not suitable for WSN. In this paper, we propose a scheme to provide both content confidentiality and source-location privacy through routing to randomly selected intermediate nodes. While being able to provide source-location privacy for WSN, our simulation results also demonstrate that the proposed scheme is efficient and can be used for practical applications.
Faculty Opinions recommendation of A Chronobiological Evaluation of the Acute Effects of Daylight Saving Time on Traffic Accident Risk. (2020)

There is evidence that the spring Daylight Saving Time (DST) transition acutely increases motor vehicle accident (MVA) risk ("DST effect"), which has been partly attributed to sleep deprivation and circadian misalignment [1-6]. Because spring DST also shifts clock time 1 h later, mornings are darker and evenings brighter, changing illumination conditions for peak traffic density. This daytime-dependent illumination change ("time of day effect") is hypothesized to result in DST-associated afternoon and evening accident risk reductions [2, 5, 7]. Furthermore, sunrise and local photoperiod timing depend on position in time zone. The sun rises at an earlier clock time in the eastern regions of a given time zone than in the western regions, which is thought to induce higher levels of circadian misalignment in the west than in the east ("time zone effect") [8, 9]. This study evaluated the acute consequences of the DST transition on MVAs in a chronobiological context, quantifying DST, time of day, and time zone effects. We used large US registry data, including 732,835 fatal MVAs recorded across all states (1996-2017), and observed that spring DST significantly increased fatal MVA risk by 6%, which was more pronounced in the morning and in locations further west within a time zone. DST-associated MVA risk increased even in the afternoon hours, despite longer daylight hours. The MVA risk increase waned in the week subsequent to DST, and there were no effects of the fall-back transition to Standard Time (ST) on MVA risk, further supporting the hypothesis that DST-transition-associated, preventable circadian misalignment and sleep deprivation might underlie MVA risk increases.Copyright © 2019 Elsevier Ltd. All rights reserved. PMID: 32008905
Involvement of electrophysiological localization of the subthalamic nucleus in deep brain stimulation for Parkinson's disease. (2008)

We studied the involvement of the electrophysiological localization of the subthalamic nucleus (NST) using a multi-unit recording technique by means of semi-microelectrode in a set of thirty Parkinson's patients who benefited from a bilateral stimulation of the NST and who were operated on under local or general anesthesia. The multi-unit recording technique by means of semi-microelectrodes appeared efficient, capable of improving the localization of the NST and leading to improvement in clinical results. We believe that the use of our technique will allow for time savings while providing good results, and that the choice of the angle of the trajectory will allow for improved localization of the NST and thus improved clinical results.
EndoSd: An IgG Glycan Hydrolyzing Enzyme in Streptococcus Dysgalactiae Subspecies Dysgalactiae (2016)

Our findings indicate that IgG glycan hydrolyzing activity is present in SDSD, and that the activity can be attributed to the here identified enzyme EndoSd.
Analysis of software as a service (SaaS) for software service provision alternative: a case study of e-office on demand service of PT. Telkom Indonesia (2012)

This research aims to explore how service providers can transform their focus from product-based into service-based by examining the e-office on demand offered by PT. Telkom Indonesia. We conduct a structured interview to evaluate the benefits, risks, challenges, sources of value creation in SaaS adoption and to study how the providers implement SaaS solution within their on-premise application. Our study shows that service providers have successfully managed the risks of SaaS and reaped SaaS benefits compared to project-based application. However, they consider customisation and integration are those issues that are still needed to be resolved.
Clinically atypical seminomas with yolk sac tumor features. (2013)

Results from this exploratory study suggest that certain CASs that express GST (pi) are more similar to YST than they are to classical seminomas, and that GST (pi) expression may be able to be used as a prognosticator of disease-specific survival. Such CASs thus may have a unique biologic origin that differs from that of classical seminomas. Additional studies are needed to determine the natural history and therapeutic implications of these CASs.
Genetic association of HLA-A*2601 with ocular Behçet's disease in Japanese patients. (2011)

Our results indicate that HLA-A*2601 is possibly associated with ocular BD, independent of HLAB* 5101, indicating that HLA-A*2601 is an additional susceptibility allele candidate of ocular BD in Japan. HLAA* 2601 would also be a possible marker for poor visual prognosis.
Mass, quark-number, and sqrt sNN dependence of the second and fourth flow harmonics in ultra-relativistic nucleus-nucleus collisions (2008)

We present STAR measurements of the azimuthal anisotropy parameter $v_2$ for pions, kaons, protons, $\\Lambda$, $\\bar{\\Lambda}$, $\\Xi+\\bar{\\Xi}$, and $\\Omega + \\bar{\\Omega}$, along with $v_4$ for pions, kaons, protons, and $\\Lambda + \\bar{\\Lambda}$ at mid-rapidity for Au+Au collisions at $\\sqrt{s_{_{NN}}}=62.4$ and 200 GeV. The $v_2(p_T)$ values for all hadron species at 62.4 GeV are similar to those observed in 130 and 200 GeV collisions. For observed kinematic ranges, $v_2$ values at 62.4, 130, and 200 GeV are as little as 10%--15% larger than those in Pb+Pb collisions at $\\sqrt{s_{_{NN}}}=17.3$ GeV. At intermediate transverse momentum ($p_T$ from 1.5--5 GeV/c), the 62.4 GeV $v_2(p_T)$ and $v_4(p_T)$ values are consistent with the quark-number scaling first observed at 200 GeV. A four-particle cumulant analysis is used to assess the non-flow contributions to pions and protons and some indications are found for a smaller non-flow contribution to protons than pions. Baryon $v_2$ is larger than anti-baryon $v_2$ at 62.4 and 200 GeV perhaps indicating either that the initial spatial net-baryon distribution is anisotropic, that the mechanism leading to transport of baryon number from beam- to mid-rapidity enhances $v_2$, or that anti-baryon and baryon annihilation is larger in the in-plane direction.
Manipulating Solid Forms of Contact Insecticides for Infectious Disease Prevention (2019)

Malaria control is under threat by the development of vector resistance to pyrethroids in long-lasting insecticidal nets, which has prompted calls for a return to the notorious crystalline contact insecticide DDT. A faster acting difluoro congener, DFDT, was developed in Germany during World War II, but in 1945 Allied inspectors dismissed its superior performance and reduced toxicity to mammals. It vanished from public health considerations. Herein, we report the discovery of amorphous and crystalline forms of DFDT and a mono-fluorinated chiral congener, MFDT. These solid forms were evaluated against <i>Drosophila</i> as well as <i>Anopheles</i> and <i>Aedes</i> mosquitoes, the former identified as disease vectors for malaria and the latter for Zika, yellow fever, dengue, and chikungunya. Contact insecticides are transmitted to the insect when its feet contact the solid surface of the insecticide, resulting in absorption of the active agent. Crystalline DFDT and MFDT were much faster killers than DDT, and their amorphous forms were even faster. The speed of action (a.k.a. knockdown time), which is critical to mitigating vector resistance, depends inversely on the thermodynamic stability of the solid form. Furthermore, one enantiomer of the chiral MFDT exhibits faster knockdown speeds than the other, demonstrating chiral discrimination during the uptake of the insecticide or when binding at the sodium channel, the presumed destination of the neurotoxin. These observations demonstrate an unambiguous link between thermodynamic stability and knockdown time for important disease vectors, suggesting that manipulation of the solid-state chemistry of contact insecticides, demonstrated here for DFDT and MFDT, is a viable strategy for mitigating insect-borne diseases, with an accompanying benefit of reducing environmental impact.
The ANGEL WSN Architecture (2007)

In this paper we present an overview of the sensor network architecture as developed in the ANGEL project. We first specify the particular requirements found in healthcare and assisted-living applications, then introduce the general reference architecture and finally discuss some security-related aspects.
Respiratory and cardiovascular responses to increased and decreased carotid sinus pressure in sleeping dogs (1995)

The purpose of this study was to determine the effects of changing blood pressure in the carotid sinus (Pcs) on ventilatory output during wakefulness and non-rapid-eye-movement sleep in unanesthetized dogs. Eight dogs were chronically instrumented so that ventilation, heart rate, and blood pressure could be measured while pressure in the isolated carotid sinus was rapidly changed by means of an extracorporeal perfusion circuit. Raising Pcs 35-75 mmHg consistently reduced ventilation 15-40% in a dose-response fashion, with little or no further diminution in minute ventilation as Pcs was further increased > 75 mmHg above control level. This decrease in minute ventilation was immediate, due primarily to a decrease in tidal volume, and was sustained over the 20-s period of elevated Pcs. Increases in Pcs also caused immediate sustained reductions in systemic blood pressure and heart rate, both of which also fell in a dose-dependent fashion. The ventilatory and systemic cardiovascular responses to increased Pcs were the same during wakefulness and non-rapid-eye-movement sleep. Decreasing Pcs 40-80 mmHg caused a sudden carotid chemoreceptor-mediated hyperpnea that was eliminated by hyperoxia. We conclude that increasing Pcs causes a reflex inhibition of ventilation and that this reflex may play a role in sleep-disordered breathing.
Object-oriented approach to PLC software design for a manufacture machinery using IEC 61131-3 norm languages (2002)

Presents an application of object-oriented methodology to the development of programmable logic controller (PLC) programs. The PLC is widely used as a computer controller of manufacturing machinery, principally because of its robustness and programming simplicity. The IEC 61131-3 norm has been introduced aiming to provide standard languages and structure to the development environments of PLC programs, that up to now have been strictly bound to proprietary languages. Following the IEC 61131-3 prescription, is it also possible to develop well structured, object-oriented control software, which was hardly possible with the former vendor-specific low-level languages. The paper describes an application of the IEC 61131-3 standard to the development of the control software of a medium complexity manufacturing machinery. The software development methodology is reported and comparison regarding development time, software re-usability and application structuring, is then discussed.
Synthesis and characterization of ethoxy‐terminated ladder‐like polymethylsilsesquioxane oligomer (2003)

Abstract A fully ethoxy‐terminated ladder‐like polymethylsilsesquioxane oligomer (EtO‐Me‐T) has been synthesized and characterized for the first time using an effective transient catalyst (tetramethylammonium hydroxide, TMAH) via the dehydration alcoholysis reaction of hydroxy‐terminated ladder‐like polymethylsilsesquioxane (HO‐Me‐T) prepared by a modified stepwise coupling polymerization approach. Compared with the common acidic or basic catalysts, use of the transient catalyst TMAH can not only make the HO‐Me‐T molecules fully ethoxy‐terminated but also enables the catalyst to be readily and thoroughly removed after completion of the alcoholysis reaction. It is noteworthy that the common acidic or basic catalysts widely used in the dehydration alcoholysis reaction are clearly unsuitable for the preparation of EtO‐Me‐T oligomer because the latter would be hydrolyzed unavoidably back to the parent HO‐Me‐T during the washing process. In addition, preliminary exploration indicates that, when compared with the tetraethyl orthosilicate (Si(OEt) 4 ) generally used as a crosslinking agent for the room‐temperature vulcanization of silicone rubber (RTV‐SR), the oligomer EtO‐Me‐T is a promising replacement which can greatly improve the mechanical properties of RTV‐SR Copyright © 2003 Society of Chemical Industry
Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP (2003)

Chronic immune thrombocytopenic purpura (ITP) is manifested by autoantibody-induced platelet destruction. Platelet turnover studies suggest that autoantibody may also affect platelet production. To evaluate this, we studied the effect of plasma from adult patients with chronic ITP on in vitro megakaryocyte production. CD34(+) cells, obtained from healthy donors, were cultured in medium containing PEG-rHuMGDF and 10% plasma from either ITP patients or healthy subjects. Cultures containing plasma from 12 of 18 ITP patients showed a significant decrease (26%-95%) in megakaryocyte production when compared with control cultures. Positive ITP plasmas not only reduced the total number of megakaryocytes produced during the culture period but also inhibited megakaryocyte maturation, resulting in fewer 4N, 8N, and 16N cells. The role of antibody in this suppression is supported by 2 factors: (1) immunoglobulin G (IgG) from ITP patients inhibited megakaryocyte production when compared with control IgG; and (2) adsorption of autoantibody, using immobilized antigen, resulted in significantly less inhibition of megakaryocyte production when compared with unadsorbed plasma. These results show that plasma autoantibody from some adult patients with ITP inhibits in vitro megakaryocyte production, suggesting that a similar effect may occur in vivo.
Comprehensive optical diagnostics of complex flow fields (1997)

This paper describes a series of promising optical diagnostic techniques to provide a comprehensive acquisition of the optical information from various flow fields under investigation. A simultaneous application of the two or even several diagnostic techniques which combines a CFD code calculations yield more accurate measurements of the density and/or the density gradient distributions in complex flow fields. Traditionally qualitative data of the density gradient in a high speed compressible flow have been obtained by schlierengraphy. A white light source and a laser two optical arms schlieren optical schemes were constructed on the base of a conventional schlieren system. The optical image of a model was focused on a photo film and projected on a screen. A CCD- camera was used to catch the focused image in real time, to display it on a control monitor and to record it on a video tape recorder. An acoustically stable holographic variable shear interferometer, which has been easily constructed on the base of the conventional schlieren system allowed to record a signal hologram during the wind tunnel run by using a continuous wave laser light source. Signal and comparison holograms have then been post-processed by the dual hologram technique to display shearing interferograms. A holographic Moire deflectometry method is presented. The holographic recording provides a 'freezing' of the distorted signal wave on a hologram to analyze it a posteriori by the Moire technique. A novel holographic Moire interferometer is described and its application to testing a small size axisymmetric supersonic air jet is shown. An interference method with enhanced sensitivity and compensating for optical aberrations, which is based on rerecording holograms is briefly described. It would provide a reliable acquisition of the phase information from wide range of weak phase objects including high speed low density flow fields. The method has been demonstrated by mapping the density field of the supersonic air jet as a representative weak phase object. The numerical analysis of a 2-D flow field was also carried out by means of computational fluid dynamics (CFD) methods.
Timely Confirmation of Gastroesophageal Reflux Disease Via pH Monitoring: Budget Impact on Managed Care Organizations (2007)

Purpose: The ACG guidelines recommend the use of pH monitoring to confirm the diagnosis of acid reflux in patients with a normal endoscopy. This analysis evaluated the financial impact of pH monitoring with the wireless pH capsule on a managed care organization (MCO) in the United States. Methods: A decision model was constructed to project total 1-year costs to manage GERD symptoms with and without the adoption of wireless pH capsules in a hypothetical MCO with 10,000 eligible adult enrollees. Costs of GERD diagnosis, treatments, and symptom management for those in whom a GERD diagnosis was ruled out by pH monitoring were assessed. The incremental per-member-per-month (PMPM) and per-treated-member-per-month (PTMPM) costs were the primary outcomes. Data sources included literature, expert input, and standardized fee schedules. Results: An increase of 10 percentage points in the use of pH monitoring with wireless pH capsules yielded incremental PMPM and PTMPM costs of $0.029 and $0.481, respectively. The costs of PPI therapy to the plan dropped to $236,363 from $238,086, while increases were observed in pH monitoring (from $16,739 to $21,973) and non-GERD therapy costs (from $1,392 to $1,740). The results were sensitive to the percentage of patients requiring repeat endoscopy before wireless pH monitoring and the cost of PPIs. Conclusion: Timely and increased use of pH monitoring as recommended in the ACG guidelines improves clinical practice and patient care. It leads to more accurate diagnosis and less unnecessary use of PPIs with only a modest budgetary impact on health plans.
Flow Profiling via Distributed Temperature Sensor (DTS) System - Expectation and Reality (2004)

Abstract Permanent downhole monitoring can provide valuable information for production decisions in real time without the need to perform an intervention to collect data. One of the commercial permanent monitoring technologies is fiber-optic distributed temperature sensor (DTS) which can record the wellbore temperature profile in real time with decent accuracy and resolution. A key potential application for DTS data is to profile injection or production for wells, which is the primary motivation and focus for this project. In the present paper a thermal model recently developed for single phase and multiphase fluid flow along a vertical, deviated or horizontal well will first be briefly described. The model can be applied for both wellbore temperature prediction (&amp;lt;i&amp;gt;forward modeling&amp;lt;/i&amp;gt;) and flow profiling using a measured temperature profile (&amp;lt;i&amp;gt;inverse problem&amp;lt;/i&amp;gt;). The model has successfully been applied for investigating key thermal characteristics of single phase and multiphase fluid flow along a wellbore. In particular, the dependence of wellbore temperature upon phases, flow profile, fluid type, fluid properties, well deviation, and Joule-Thomson effect, will be demonstrated in the paper. The model has further been adapted for directly predicting production and injection profiles (i.e., flow profiling) based on given wellbore temperature profile. The potential impact of noise in the DTS measurement on flow profiling has been explored. It is found that the wellbore temperature does not change significantly along horizontal or near horizontal sections due to the small variation in geothermal temperature, therefore, just based on DTS data, the amount and the location of each fluid entry would be difficult to be identified. The current study shows that a maximum wellbore deviation of 75 degrees should be honored to appropriately estimate flow profile directly through DTS data. The study has also led to an observation that under certain circumstances like multiphase flow, a production profile may be determined via DTS temperature measurement with extra data or information provided. The types of the extra measurements and the appropriate approaches will be recommended.
Optical frequency scanning of a stabilised and linewidth-reduced multielectrode DFB laser using current feedback (1987)

Optical frequency scanning of a stabilised and linewidth-reduced multielectrode DFB laser has been demonstrated using a current feedback technique. The scanning range of the linewidth-reduced multielectrode DFB laser was 4Å (50 GHz) and 9Å (120 GHz) when the linewidth was reduced to 1/50 and 1/20, respectively, of that of a free-running state laser.