gebhart/patrepeval huggingface dataset:
Electrochemically assisted fast atom bombardment mass spectrometry (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemically assisted fast atom bombardment mass spectrometryJohn E. Bartmess and Lawrence R. PhillipsCite this: Anal. Chem. 1987, 59, 15, 2012–2014Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ac00142a026https://doi.org/10.1021/ac00142a026research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Circulating levels of the cytokines IL10, IFNγ and resistin in an obese mouse model of developmental programming (2013)

An infant's early developmental environment plays a pivotal role in the programming of its physiological phenotype. The identification of the factors in the maternal environment that mediate the effects of maternal obesity and diet is essential to the development of clinical intervention strategies. Maternal hyperglycaemia, hyperinsulinaemia, hypertriglyceridaemia, hyperleptinaemia and altered inflammatory cytokines concentrations are potentially important predictive factors of her future offspring's susceptibility to metabolic disease. Using a diet-induced obese mouse model, we have investigated which of these maternal factors could induce adverse metabolic programming in the offspring. Female C57Bl/6 mice were fed either laboratory chow (10% fat) or high fat diet (42% fat) for 10 weeks before mating and throughout gestation. At day 18 of pregnancy, maternal body weight, body composition and glucose tolerance were measured, as well as plasma insulin, adiponectin, RBP4, leptin, resistin and the inflammatory cytokines (IL6, IL10, IL12, IL1β, IFNγ, KC, TNF-α). At day 18 of pregnancy, high fat-fed dams were significantly heavier than the chow dams and had increased fat mass. High fat-fed dams had higher 5 h fasting blood glucose than chow dams and elevated plasma insulin. Although the obese dams had both reduced plasma adiponectin and resistin levels compared with lean dams, their plasma IL6, IL10 and IFNγ levels were all increased. High fat feeding in pregnancy leads to altered plasma concentrations of both adipokines and adipocytokines in the dam that may directly pass to the fetus and affect their development.
Cryptosporidiose humaine et espèces en cause en Haïti (2006)

Contamination by water-born infectious diseases is closely linked to urban slums conditions such as overcrowding and high level of faecal pollution by animal and human excreta. In this environment, cryptosporidiosis is a major cause of acute diarrhoea in children and chronic persistent diarrhoea in AIDS patients, resulting in increased morbidity and mortality in both populations. The aims of this study conducted in Port-au-Prince, Haiti were to: (i) determine the frequency of Cryptosporidium infection in two populations of patients with diarrhoea, children and AIDS patients, and the existence of Cryptosporidium carriage in healthy adults living in close contact with them; (ii) identify by molecular genotyping the Cryptosporidium species involved; and (iii) evaluate the viability of Cryptosporidium oocysts isolated from human stools. From January 2000 to January 2001, 158 of 1529 diarrhoea stool samples collected from 93 patients with diarrhoea, 57 adults followed at Centres GHESKIO and 36 children admitted at the University Hospital in Port-au-Prince contained Cryptosporidium oocysts (10.3%). The majority of adult patients (98%) were HIV-infected whereas the majority of children (81%) tested negative for HIV. Cryptosporidium was documented in only 1/102 healthy persons living in contact with Cryptosporidium infected patients and infection was with the same genotype as that of the contact patient. Among the 69 Cryptosporidium isolates studied for genotyping, three species were identified: C. hominis (59%), C. parvum (38%) and C. felis (3%). The two C. felis cases are the first reported from AIDS patients in the Caribbean. Most of the children regardless of their HIV status were infected with C. hominis (72%), whereas AIDS patients were more likely to be infected by either human or animal genotypes. These data confirm that immunocompromised individuals are susceptible to a wide range of Cryptosporidium spp. Viability of Cryptosporidium oocysts were determined in an experimental mouse model for 17/18 specimen studied including in 12/13 C. hominis, 4/4 C. parvum and 1/1 C. felis. Infectivity in newborn mice was found to be dose-dependent and more effective with C. parvum than the other two genotypes. Cryptosporidiosis remains a frequent hazard for both AIDS patients and young children in Haiti because of poor hygiene, particularly contaminated water and overcrowded conditions associated with urban slums.
Can Increased Locomotor Task Difficulty Differentiate Knee Muscle Forces After Anterior Cruciate Ligament Reconstruction? (2022)

Changes in knee mechanics following anterior cruciate ligament (ACL) reconstruction are known to be magnified during more difficult locomotor tasks, such as when descending stairs. However, it is unclear if increased task difficulty could distinguish differences in forces generated by the muscles surrounding the knee. This study examined how knee muscle forces differ between individuals with ACL reconstruction with different graft types (hamstring tendon and patellar tendon autograft) and "healthy" controls when performing tasks with increasing difficulty. Dynamic simulations were used to identify knee muscle forces in 15 participants when walking overground and descending stairs. The analysis was restricted to the stance phase (foot contact through toe-off), yielding 162 separate simulations of locomotion in increasing difficulty: overground walking, step-to-floor stair descent, and step-to-step stair descent. Results indicated that knee muscle forces were significantly reduced after ACL reconstruction, and stair descent tasks better discriminated changes in the quadriceps and gastrocnemii muscle forces in the reconstructed knees. Changes in quadriceps forces after a patellar tendon graft and changes in gastrocnemii forces after a hamstring tendon graft were only revealed during stair descent. These results emphasize the importance of incorporating sufficiently difficult tasks to detect residual deficits in muscle forces after ACL reconstruction.
Neural network-based indoor tag-less localization using capacitive sensors (2019)

Many applications aim to make smarter the indoor environments where most people spend much of their time (home, office, transportation, public spaces), but they need long-term low-cost human sensing and monitoring capabilities. Small capacitive sensors match well most requirements, like privacy, power, cost, and unobtrusiveness, and, importantly, they do not rely on wearables or specific human interactions. However, long-range capacitive sensors often need advanced data processing to increase their performance. Our ongoing research experimental results show that four 16 cm X 16 cm capacitive sensors deployed in a 3 m X 3 m room can taglessly track the movement of a person with a root mean square error as low as 26 cm. Our system uses a median and low-pass filter for sensor signal conditioning before an autoregressive neural network that we trained to infer the location of the person in the room.
Finite-Element Codes to Model Electrical Heating and Non-Linear Thermal Transport in Biological Media (1997)

Abstract ETherm is a versatile finite-element software system to model heating in biological media for electrosurgery and other medical applications. The electrical field component calculates penetration of RF radiation into conductive dielectrics. The thermal solver finds time-dependent or steady-state solutions using stable diffusion methods with automatic time step adjustment. An important feature is the capacity to treat non-linear diffusion with temperature-dependent thermal properties such as blood perfusion to represent physical changes of tissues. The program also evaluates Arrhenius damage integrals by maintaining temperature integrals over tissue elements.
Sutureless, rapid deployment valves and stented bioprosthesis in aortic valve replacement: recommendations of an International Expert Consensus Panel (2015)

The international experts recommend various benefits of sutureless and rapid deployment technology, which may represent a helpful tool in aortic valve replacement for patients requiring a biological valve. However, further evidence will be needed to reaffirm the benefit of sutureless and rapid deployment valves.
Tailoring sphere density for high pressure physical property measurements on liquids (2001)

We present a new method of tailoring the density of a sphere for use as a probe in high pressure-temperature physical property experiments on liquids. The method consists of a composite sphere made of an inner, high density, metallic, spherical core and an exterior, low density, refractory, spherical shell or mantle. Micromechanical techniques are used to fabricate the composite sphere. We describe a relatively simple mechanical device that can grind hemispherical recesses as small as 200 μm in diameter in sapphire and as small as 500 μm in diameter in ruby hemispheres. Examples of composite spheres made with a Pt or WC core and Al2O3 shell used in metallic liquids pressurized to 16 GPa and 1900 K are shown.
Electrical Detection of Spin Accumulation at a Ferromagnet-Semiconductor Interface (2006)

We show that the accumulation of spin-polarized electrons at a forward-biased Schottky tunnel barrier between Fe and n-GaAs can be detected electrically. The spin accumulation leads to an additional voltage drop across the barrier that is suppressed by a small transverse magnetic field, which depolarizes the spins in the semiconductor. The dependence of the electrical accumulation signal on magnetic field, bias current, and temperature is in good agreement with the predictions of a drift-diffusion model for spin-polarized transport.
Multi-Channel Chatbot and Robotic Process Automation (2022)

RPA (Robotic Process Automation) is a software-based solution that automates rule-based business processes such as repetitive actions, structured data, and predictable outcomes. The purpose of this paper is to demonstrate how a multi-channel chatbot can be created and implemented, as well as how Robotic Process Automation (RPA) may be connected with the chatbot to automate a business process, therefore easing the repetitious labor of a business's workers. The goal is to let consumers to explore and purchase products through chatbot, and then send an email with an invoice to the sales department and the customer. The whole process outlined above should be automated, with no human agents interacting until specifically requested. To be completed, the process must operate consistently across all channels, and all components must communicate and exchange information.
PERFORMANCE OF LOW COST RADIOS IN THEIMPLEMENTATION OF LONG DISTANCE WIRELESS LINKS (2008)

Low cost digital radios are emerging as an efficient resource for the realization of long distance (multikilometric) point-to-point telecommunication infrastructures in underdeveloped and Third World Countries. To analyze the performance of these architectures, we realized several LOS wireless links ranging from 50 to 300 kilometers. The links were based on the use of commercial IEEE802.11a/h radios. For the purpose of the research, an open source control software implementing significant modifications to the MAC layer of the standard was implemented. Experimental results show excellent performance and stability, even when the link ranges more than 100 km
Nitrofurantoin and Peripheral Neuropathy (1985)

Letters and Corrections1 January 1985Nitrofurantoin and Peripheral NeuropathyART JACKNOWITZ, Pharm. D.ART JACKNOWITZ, Pharm. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-138_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The review by Snavely and Hodges (1) provides a clear discussion of the neurotoxic potential of commonly prescribed antimicrobial agents. However, in the section describing agents capable of causing peripheral nerve toxicity, nitrofurantoin was omitted. Indeed, a major problem associated with nitrofurantoin has been the occasional development of polyneuropathy (2).Nitrofurantoin polyneuropathy may develop in patients with normal renal function, if prolonged courses of nitrofurantoin are used. In addition, changes in nerve conduction have been found without clinical features of neuropathy after a 2-week course of nitrofurantoin, 400 mg/d, in healthy volunteers. This complication has also been...References1. SNAVELYHODGES SG. The neurotoxicity of antibacterial agents. Ann Intern Med. 1984;101:92-104. LinkGoogle Scholar2. JACKNOWITZLEFROCKPRINCE AJR. Nitrofurantoin polyneuropathy: report of two cases. Am J Hosp Pharm. 1977;34:759-62. MedlineGoogle Scholar1. SNAVELYHODGES SG. The neurotoxicity of antibacterial agents. Ann Intern Med. 1984;101:92-104. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Virginia University Morgantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1985Volume 102, Issue 1Page: 138-139KeywordsAntimicrobialsNervesNeuropathyPeripheral neuropathyToxicity Issue Published: 1 January 1985 PDF DownloadLoading ...
Epidemiological and Immunological Features of Obesity and SARS-CoV-2 (2021)

Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.
Terahertz imaging applied to the examination of artistic objects (2014)

Terahertz (THz) radiation can be employed onsite for the analysis of museum artifacts related to art conservation science. This review presents two complementary portable THz imaging devices which have been employed at the Tokyo National Museum (Japan) and at the Museum of Aquitaine (France). A Japanese panel screen, African fetish figures, and a nearly 3500-year-old sealed Egyptian jar were imaged with THz waves, revealing their internal structures.
Description of Vapor-Liquid Equilibria for CO2 in Electrolyte Solutions Using the Mean Spherical Approximation (2003)

The mean spherical approxn. is used to describe the vapor pressure over aq. solns. contg. an electrolyte and carbon dioxide. Three electrolytes have been studied: NaOH, NaCl, and acetic acid. A good representation was obtained with a reduced no. of parameters as compared to previous models. These parameters account for the concn. and temp. dependence of the solute sizes and the relative permittivity of soln. The numerical values of these phys. interpretable parameters are in a reasonable range.
Expression of different glucansucrases in potato tubers: implications for starch biosynthesis (2005)

This thesis describes the production of dextran (polymers with -(1→6)-linked glucosyl residues), mutan (polymers with -(1→3)-linked glucosyl residues) and alternan (polymers with alternating -(1→3)/ -(1→6)-linked glucosyl residues) in potato tubers. Modifications of the physicochemical properties of potato starch were&nbsp; investigated as well as the possibilities to introduce novel linkage types in starch. The most pronounced alterations at the tuber and starch levels were obtained in the mutan-accumulating potato plants. The tuber phenotype exhibited brownish regions, granule morphology was dramatically affected and the expression level of the sucrose-regulated AGPase and GBSSI genes was down-regulated. Furthermore, the starches showed more pronounced retrogradation after gelatinization, and had a 1.7-fold higher viscosity after cooling than untransformed starches. In general, introduction of novel linkage types in starch was not evidenced. More research is needed to investigate the possibilities of engineering a second generation of glucansucrases with improved capacities to introduce novel linkage types in starch.
<title>Recursively weighting pixel domain intra prediction on H.264</title> (2003)

Intra coding for lossy block base transform video coding and still picture coding has been studied. In H.264, pixel domain prediction is applied, where all pixel values in a block are predicted from decoded images in surrounding blocks. There are some advantages in pixel domain prediction comparing with DCT domain prediction. One thing is that in pixel domain prediction, residual data at block boundaries becomes smaller. On the other hand, in pixel base prediction scheme for lossless coding, each pixel value is predicted from surrounding pixels generally. In Multiplicative Autoregressive Models (MAR) or JPEG-LS, each pixel is predicted from some neighboring pixels. This pixel base prediction scheme is more effective to reduce prediction error than block base prediction. In this paper, the new intra prediction method, Recursively Weighting pixel domain Intra Prediction (RWIP) method for block base transform coding is proposed. The RWIP applies similar approach to pixel base prediction scheme in order to reduce prediction error more than the conventional block base prediction scheme, especially for blur or complicated directional edge images. This paper also demonstrates the efficiency of the RWIP over the normal intra prediction of H.264.
Electrically pumped InP-based microdisk lasers integrated with a nanophotonic silicon-on-insulator waveguide circuit (2007)

A compact, electrically driven light source integrated on silicon is a key component for large-scale integration of electronic and photonic integrated circuits. Here we demonstrate electrically injected continuous-wave lasing in InP-based microdisk lasers coupled to a sub-micron silicon wire waveguide, fabricated through heterogeneous integration of InP on silicon-on-insulator (SOI). The InP-based microdisk has a diameter of 7.5 mum and a thickness of 1 mum. A tunnel junction was incorporated to efficiently contact the p-side of the pn-junction. The laser emits at 1.6 mum, with a threshold current as low as 0.5 mA under continuous-wave operation at room temperature, and a threshold voltage of 1.65 V. The SOI-coupled laser slope efficiency was estimated to be 30 muW/mA, with a maximum unidirectional output power of 10 muW.
ChemInform Abstract: STUDIES ON ORGANIC FLUORINE COMPOUNDS. XX. SYNTHESIS AND REACTIONS OF A SUBSTITUTED DEWAR PYRIDINE (1977)

Abstract Die Photolyse der Pyridins (I) liefert das stabile Dewar‐Pyridin (II), das thermolytisch wieder in (I) übergeht.
Evaluation of Computed Tomographic Methods to Measure Vertebral Rotation in Adolescent Idiopathic Scoliosis (1998)

The purpose of this study was to compare three computed tomography (CT) measurement methods that have been described by Aaro-Dahlborn, Ho, and Krismer et al. The methods were based on clinical, intraobserver, and interobserver analysis. Twenty-five patients with adolescent idiopathic scoliosis were studied for clinical reliability of these methods. There was a significant correlation between Aaro-Dahlborn and Ho's methods (p < 0.02), and there was no correlation between Krismer's method and the other two (p > 0.05). Intraobserver analysis was performed by one observer at 20 different times, and interobserver analysis was performed by 20 orthopedic surgeons on the same CT scan. Intraobserver and interobserver analysis has shown that the method described by Ho is the most reliable one. Consequently, Ho's method is the most reliable and clinically the most useful method for measuring the vertebral rotation in adolescent idiopathic scoliosis.
An invariance principle for differential-algebraic equations with jumps (2014)

In this paper, we consider dynamical systems with multiple modes of operation and state jumps. Within each mode, the dynamics are given by linear differential-algebraic equations (DAEs). State jumps can occur when in a fixed mode as well as when transitioning between modes. We refer to this class of hybrid systems as hybrid DAEs. Motivated by the lack of results to study invariance properties of nonsmooth DAE systems, we characterize the properties of the omega limit set of solutions to these systems and propose an invariance principle. To this end, we employ results allowing for decomposition of DAEs (and switched DAEs) into the so-called quasi-Weierstrass form and for the study of invariance of hybrid inclusions. The results are illustrated in examples.
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells (2014)

Pyruvate dehydrogenase kinase (PDK) is a pivotal enzyme in cellular energy metabolism that has previously been implicated in cancer through both RNAi based studies and clinical correlations with poor prognosis in several cancer types. Here, we report the discovery of a novel and selective ATP competitive pan-isoform inhibitor of PDK, VER-246608. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. However, these effects were only observed under D-glucose-depleted conditions and required almost complete ablation of PDC E1α subunit phosphorylation. VER-246608 was weakly anti-proliferative to cancer cells in standard culture media; however, depletion of either serum or combined D-glucose/L-glutamine resulted in enhanced cellular potency. Furthermore, this condition-selective cytostatic effect correlated with reduced intracellular pyruvate levels and an attenuated compensatory response involving deamination of L-alanine. In addition, VER-246608 was found to potentiate the activity of doxorubicin. In contrast, the lipoamide site inhibitor, Nov3r, demonstrated sub-maximal inhibition of PDK activity and no evidence of cellular activity. These studies suggest that PDK inhibition may be effective under the nutrient-depleted conditions found in the tumour microenvironment and that combination treatments should be explored to reveal the full potential of this therapeutic strategy.