gebhart/patrepeval huggingface dataset:
Abstract 4444: The role of small GTPase Rab7 in the secretion of extracellular microvesicles by head and neck squamous cells carcinoma (2014)

Abstract Head and neck squamous cell carcinoma (HNSCC) is an epithelial malignant tumor that shows its highest incidence in the upper aerodigestive tract and is considered one of the six most common malignancies worldwide. Among the processes involved in the poor prognosis of HNSCC, local invasion and subsequent metastasis are the most important events. Recent evidences have shown that metastasis can be the result of extracellular microvesicles (MVEs) being released from the tumor cells to the blood or lymphatic system. The molecular mechanisms involved in MVEs biogenesis and secretion are, however, poorly understood. Herein, we have performed a screen targeting for the components of MVEs biogenesis in three HNSCC cell lines (SCC-9, Cal27 and FaDu) through western blotting. MVEs were quantified using Nanoparticle Tracking Analysis (NTA - NanoSight®) and the lysosomal compartment was followed in the cell lines through immunofluorescence. Comparing the three cell lines, FaDu cells presented higher expression of proteins responsible for MVEs formation (p&amp;lt;0.05), such as Flotilin-1, Tsg101, VPS36 and also Rab7, a small GTPase that directs vesicles to lysosomes. However, FaDu cells secreted less MVEs than SCC-9 and Cal27. Immunofluorescence experiments showed the presence of numerous perinuclear clusters positive to LAMP-1 (lysosome marker) in FaDu cells, while SCC-9 and Cal27 showed LAMP1-positive organelles dispersed throughout their cytoplasms. Taken together, the results highlight a role for Rab7 protein in the negative regulation of MVEs secretion by HNSCC cell lines, which may provide important information related to tumor progression, treatment response, and especially the development of metastasis. Supported by São Paulo Research Foundation (FAPESP) Citation Format: Fernanda S. Giudice, Bruna R. Rodrigues, Marcos V. S. Dias, Antuani R. Baptistella, Tonielli Cristina S. Lacerda, Luiz P. Kowalski, Vilma R. Martins. The role of small GTPase Rab7 in the secretion of extracellular microvesicles by head and neck squamous cells carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4444. doi:10.1158/1538-7445.AM2014-4444
A new modulation strategy for a buck-boost input AC/DC converter (2001)

This paper presents a novel modulation strategy for a power factor corrected (PFC), isolated AC/DC converter derived from the integration of a nonisolated, two switch buck-boost AC/DC converter with an isolated dual active bridge DC/DC converter (2SBBDAB). This strategy, termed discontinuous leading/trailing edge (DLTE) modulation, serves to maximize the duty cycle of the input switch while keeping the current in the buck-boost inductor discontinuous. Hence, the crest factors of the currents in the switching devices are minimized, the input switch is turned on at zero current and the zero-voltage switching ranges of the bridge switches are unaffected by the integration. A conventional isolated, PFC AC/DC converter typically consists of a boost converter cascaded with a forward converter. The ratings required of the power switching devices of the 2SBBDAB employing the DLTE modulation strategy are similar to those required of the conventional design for wide line voltage operation. However, the 2SBBDAB converter has higher line voltage surge immunity than that of the conventional design and, unlike the conventional design, it has inherent inrush current limiting. The DLTE modulation strategy may be applied to the family of converters composed of the two switch buck-boost integrated with half and full-bridge forward converters.
SOLID-STATE SERVICES (2007)

RETURN TO ISSUEPREVNewsNEXTSOLID-STATE SERVICESSpecialized companies help drug developers find CRYSTALLINE FORMS with the right propertiesANN M. THAYERView Author Information C&EN HOUSTONCite this: Chem. Eng. News 2007, 85, 25, 31–34Publication Date (Print):June 18, 2007Publication History Published online29 October 2010Published inissue 18 June 2007https://pubs.acs.org/doi/10.1021/cen-v085n025.p031https://doi.org/10.1021/cen-v085n025.p031newsACS PublicationsCopyright © 2007 American Chemical SocietyArticle Views19Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Pharmaceuticals Get e-Alerts
A hybrid ARQ scheme with adaptive forward error correction for satellite communications (1991)

A hybrid automatic-repeat-request system combined with adaptive forward error correction (ARQ/AFEC) which adaptively alters the error-correcting capability according to channel state using a nonsystematic Reed-Solomon code is presented. lt is shown that the system can alter the error-correcting capability by varying the number of information symbols fed to the decoder only, and not change the hardware of the encoder. Performance evaluations indicate that the ARQ/AFEC system has much higher frame efficiency than ARQ without AFEC for low-bit error rate and has high frame efficiency in a wide range of bit error rates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparisons of diazotrophic communities in native and agricultural desert ecosystems reveal plants as important drivers in diversity (2015)

Diazotrophs provide the only biological source of fixed atmospheric nitrogen in the biosphere. Although they are the key player for plant-available nitrogen, less is known about their diversity and potential importance in arid ecosystems. We investigated the nitrogenase gene diversity in native and agricultural desert soil as well as within root-associated microbiota of medicinal plants grown in Egypt through the combination of nifH-specific qPCR, fingerprints, amplicon pyrosequencing and fluorescence in situ hybridization-confocal laser scanning microscopy. Although the diazotrophic microbiota were characterized by generally high abundances and diversity, statistically significant differences were found between both soils, the different microhabitats, and between the investigated plants (Matricaria chamomilla L., Calendula officinalis L. and Solanum distichum Schumach. and Thonn.). We observed a considerable community shift from desert to agriculturally used soil that demonstrated a higher abundance and diversity in the agro-ecosystem. The endorhiza was characterized by lower abundances and only a subset of species when compared to the rhizosphere. While the microbiomes of the Asteraceae were similar and dominated by potential root-nodulating rhizobia acquired primarily from soil, the perennial S. distichum generally formed associations with free-living nitrogen fixers. These results underline the importance of diazotrophs in desert ecosystems and additionally identify plants as important drivers in functional gene pool diversity.
[Local therapy with capsaicin or ASS in chronic pain]. (1997)

Capsaicin is a white crystalline parent compound of a group of vanillyl fatty acid amines. Because of its highly specific action in neurons it has become an important tool in neuroscience. Because of its effects, it is obvious to try for the therapy of circumscribed neuropathic pain. Capsaicin acts by depleting stores of substance P and other neurotransmitters, resulting in a blockade of a specific group of sensory afferents. The corresponding clinical findings are initial burning and a desensitization of specific C fiber nociceptors after repeated application. The pain relieving potency was observed in various clinical investigations and even in a few controlled, double-blind studies about neuropathic pain syndromes and (osteo)arthritis. In contrast to these findings, a recent study found no significant benefit of capsaicin, probably because this study was the first to use an active placebo. Therefore, and because clinical efficacy and advantages over other therapies have not been demonstrated up to now, capsaicin cannot be classified as standard therapy. It may be a therapeutic option as an alternative or as an adjuvant treatment. Pain reduction was also observed after topical application of ASA/ether mixture in the one and only controlled double-blind study on this issue. Therefore, topical ASA therapy for (post)herpetic neuralgia is mainly based on a few enthusiastic case reports rather than on well founded investigations. Furthermore, the discrimination of local from systemic effects, the toxicological profile of longterm topical treatment, and the mechanism of action has not been evaluated. In conclusion, topical ASA cannot be recommended for routine clinical use at present.
An Overview on Implicit Green Business Process Patterns (2013)

The environmental impact of doing business becomes an increasingly relevant aspect for organizations, not only because of legal requirements but also because more customers care about environmental influences. Most organizations, however, do not have comprehensive knowledge on how to restructure their business processes accordingly. In previous work we proposed green business process patterns that address the environmental impact explicitly as one possible solution. Beyond those patterns, we now provide environmentally relevant patterns derived from existing patterns of different domains. In this work, we present a set of such patterns related to automated business processes. The identified patterns support stakeholders when analyzing their business processes with respect to the environmental impact and, therefore, supporting green business process reengineering. Report 2013/05 Institute of Architecture of Application Systems (IAAS) Page 3 of 35
Cambricon: An Instruction Set Architecture for Neural Networks (2016)

Neural Networks (NN) are a family of models for a broad range of emerging machine learning and pattern recondition applications. NN techniques are conventionally executed on general-purpose processors (such as CPU and GPGPU), which are usually not energy-efficient since they invest excessive hardware resources to flexibly support various workloads. Consequently, application-specific hardware accelerators for neural networks have been proposed recently to improve the energy-efficiency. However, such accelerators were designed for a small set of NN techniques sharing similar computational patterns, and they adopt complex and informative instructions (control signals) directly corresponding to high-level functional blocks of an NN (such as layers), or even an NN as a whole. Although straightforward and easy-to-implement for a limited set of similar NN techniques, the lack of agility in the instruction set prevents such accelerator designs from supporting a variety of different NN techniques with sufficient flexibility and efficiency. In this paper, we propose a novel domain-specific Instruction Set Architecture (ISA) for NN accelerators, called Cambricon, which is a load-store architecture that integrates scalar, vector, matrix, logical, data transfer, and control instructions, based on a comprehensive analysis of existing NN techniques. Our evaluation over a total of ten representative yet distinct NN techniques have demonstrated that Cambricon exhibits strong descriptive capacity over a broad range of NN techniques, and provides higher code density than general-purpose ISAs such as ×86, MIPS, and GPGPU. Compared to the latest state-of-the-art NN accelerator design DaDianNao [5] (which can only accommodate 3 types of NN techniques), our Cambricon-based accelerator prototype implemented in TSMC 65nm technology incurs only negligible latency/power/area overheads, with a versatile coverage of 10 different NN benchmarks.
[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. (1999)

We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders. The efficacy and side effects of melatonin at bedtime were evaluated in 50 children and young adults with sleep disorders (3-28 years old, 41 males and 9 females, autism [AU] in 27 patients, mentally retardation [MR] in 20 patients, and severe motor and intellectual disability [SMID] in 3 patients). The sleep disorders consisted of various types of insomnia in 44 patients and of circadian rhythm sleep disorders in 6 patients. Thirty nine of the insomnia patients and 3 of the circadian rhythm sleep disorder patients experienced improvement in response to melatonin. In some cases, the efficacies were diminished after the daily medication of melatonin. With the emotional/behavior disturbances, excitabilities were often improved in cases whose sleep disorders were also improved. There was almost no change in contrariness, stereotyped behavior and in school/workshop refusal. Melatonin at bedtime was efficacious in 42 of the 50 patients with sleep disorders. In 17 patients, there were side effects (residual drowsiness on the next morning, awakening in the middle of sleep, excitement after awakening and before going to sleep, etc.). But these side effects were not serious. The effects of melatonin were influenced by the type of sleep disturbances, the factors of the environment and the mental conditions. Taking side effects into account, we judged melatonin to be useful in 34 patients.
Return to Play After Shoulder Instability Surgery in National Collegiate Athletic Association Division I Intercollegiate Football Athletes (2017)

The majority of surgical interventions were isolated arthroscopic stabilization procedures, with no statistically significant difference in RTP rates when concomitant arthroscopic procedures or open stabilization procedures were performed. Athletes who returned to play often played in a higher percentage of games after surgery than before the injury, and many played at the same or a higher level after surgery.
Outcomes associated with acute kidney disease: a systematic review and meta-analysis (2022)

This study was supported by Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) [grant number, MOST 107-2314-B-002-026-MY3, 108-2314-B-002-058, 110-2314-B-002-241, 110-2314-B-002-239], National Science and Technology Council (NSTC) [grant number, NSTC 109-2314-B-002-174-MY3, 110-2314-B-002-124-MY3, 111-2314-B-002-046, 111-2314-B-002-058], National Health Research Institutes [PH-102-SP-09], National Taiwan University Hospital [109-S4634, PC-1246, PC-1309, VN109-09, UN109-041, UN110-030, 111-FTN0011] Grant MOHW110-TDU-B-212-124005, Mrs. Hsiu-Chin Lee Kidney Research Fund and Chi-mei medical center CMFHR11136. JAN is supported, in part, by grants from the National Institute of Health, NIDDK (R01 DK128208 and P30 DK079337) and NHLBI (R01 HL148448-01).
p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells (2012)

Overall, these data identify a new p130Cas/Cyclooxygenase-2 axis as a crucial element in the control of breast tumor plasticity, opening new therapeutic strategies leading to inhibition of these pathways in aggressive breast carcinoma.
ChemInform Abstract: Structural Effects on (1,5)Sigmatropic Hydrogen Shifts of Vinylallenes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The uses and misuses of orchids in medicine (2005)

We are now aware that medicines need to be tested before being consumed by human beings. Today, this takes the form of experimentation to assess toxicity, and subsequent randomized control trials to assess both efficacy and adverse effects. However, orchid products, the tubers, leaves or flowers, were introduced into medicine with no such testing, and ultimately their use has declined, not through being proven ineffective, but more through lack of evidence and changes in fashion.

This article examines the medicinal uses of orchid plants in the Orient, Europe, the Americas, Australia and Africa, and concludes by examining their usage today.

There is no doubt that the Chinese were the first to cultivate and describe orchids, and they were almost certainly the first to describe orchids for medicinal use. Reinikka reports1 a Chinese legend that Shen-nung described Bletilla striata and a Dendrobium species in his Materia Medica of the 28th century BC. The earliest Middle East report of plant remedies is in a 4000-year-old Sumerian clay tablet,2 but I do not know if this included any orchids. Shen-nung's herbal ‘cures’ were probably published many times, but were certainly published in 1600 in the Pun-tsae , a pharmacopoeia.2–4 Confucius (551–479 BC) called the orchid ( lan in Chinese) the ‘King of Fragrant Plants’, and Chinese writings indicated that they stood for many things: ‘retirement, friendship, perfection, numerous progeny, all things feminine, noble and elegant’1—and some of these themes were echoed in Europe.

The Chinese were also the first to write books devoted to orchids. In 1233, Chao Shih-K![Graphic][1] ng wrote Chin Chan Lan P'u , and described 20 species and how to grow them.3 In 1247, Wang Kuei-hsueh wrote his Treatise on Chinese orchids , and described 37 species. The first Western volumes dedicated to orchids did …

 [1]: /embed/inline-graphic-1.gif
Defining an Error Typology: the Case of CELTraC (2016)

Tato bakalařska prace ma za cil definovat kategorie chybove typologie korpusu studentských překladů CELTraC, který se v soucasne době použiva na Katedře anglistiky a amerikanistiky. Jelikož jeden z hlavnich důvodů kompilace tohoto korpusu byla analýza chyb při překladu, absence chybových definic zbytecně ztěžuje praci se shromažděnými daty. V teoreticke casti jsou porovnany různe systemy anotaci chyb, zatimco prakticka cast obsahuje samotne definice každe kategorie v typologii korpusu CELTraC.
Pilot feedback for an automated planning aid system in the cockpit (2009)

It is the primary responsibility of the airline pilot to safely complete a flight plan and safely land the airplane. This task can become very difficult in the face of an onboard emergency. One of the challenging tasks faced by the pilots in case of an emergency is the determination of an appropriate landing site as well as the development of a safe trajectory to reach that site. An Automated Planning Aid (APA) can assist the pilot with the tasks of selecting a landing site and developing a suitable trajectory to land. In order to evaluate such an APA, a survey of airline pilots was conducted during the late summer of 2008. The participants were presented with several questions related to the task of planning a path during a performance altering emergency, a non-performance altering emergency and an unforeseen emergency. Participants were also presented with questions about how they would prefer to interact with an APA in the cockpit and the circumstances under which such a device might be most useful. The results of the survey showed that time was the most important criterion to consider, however the methods pilots use to complete the landing site selection and trajectory development tasks vary with the type of emergency and the pilot's familiarity with the circumstances. The results of the survey are used to understand the mental processes currently used by the pilots to complete the path planning task as well as to provide insights to how an APA could be most useful during an onboard emergency.
AVID: A Global Alignment Program (2002)

In this paper we describe a new global alignment method called AVID. The method is designed to be fast, memory efficient, and practical for sequence alignments of large genomic regions up to megabases long. We present numerous applications of the method, ranging from the comparison of assemblies to alignment of large syntenic genomic regions and whole genome human/mouse alignments. We have also performed a quantitative comparison of AVID with other popular alignment tools. To this end, we have established a format for the representation of alignments and methods for their comparison. These formats and methods should be useful for future studies. The tools we have developed for the alignment comparisons, as well as the AVID program, are publicly available. See Web Site References section for AVID Web address and Web addresses for other programs discussed in this paper.
Synthesis of Titanium-Containing Mesoporous Silicas as Catalysts for Cyclohexene Epoxidation (2009)

Ti-containing mesoporous materials have been prepared by hydrothermal synthesis at 100 °C with two different Si/Ti ratios (20 and 60) in the synthesis mixture. A detailed study about the effect of synthesis time on the physicochemical properties of the materials has been carried out. The samples were characterized by XRD, DRUVvis, N2 adsorption, and pyridine adsorption analyzed by FT-IR. The samples synthesized using the lower Si/Ti ratio presented the higher titanium incorporation and the higher acid character. The synthesis time appears as an important parameter that affects the textural, structural, chemical, and acid properties of the final solids. For the lower Si/Ti ratio, a longer synthesis time is needed to obtain a more ordered structure. However, in both cases, short synthesis times do not allow a proper incorporation of titanium into the silica framework, which is reached with synthesis times of about 3 days. The results of catalytic activity indicate that the solids studied here present an interesting potential as catalysts in the selective oxidation of cyclohexene using H2O2.
Relief Phase Contrast:A New Technique for Phase-Contrast Light Microscopy (2007)

Relief phase contrast is a new modification of conventional phase contrast which leads to visible improvements of image quality in light microscopy. In particular, the following parameters can be improved: contrast, focal depth, sharpness, three dimensionality, planeness, and halo artifacts. These effects can be achieved when the ring-shaped masks in the condenser are replaced by crescent- or punctate-shaped masks. Several solutions are described which are suitable to create this modification. The achievable improvements of image quality are relevant for all quality levels of objectives. The new technique can be used for phase contrast objectives from different manufacturers, so that the usual limitations of compatibility are eliminated.