gebhart/patrepeval huggingface dataset:
Abstract 2457: Nestin regulates pancreatic cancer stem cell functions (2011)

Abstract Background: Nestin, a class VI intermediate filament protein, was originally described as a neuronal stem cell/progenitor cell marker. Nestin expression has also been shown to be up-regulated in progenitor cells in muscle, testis, teeth and pancreas. In the pancreas, lineage-tracing experiments have indicated that exocrine cells are derived from Nestin-expressing progenitor cells. Moreover, activation of K-ras in the nestin cell lineage is sufficient for the initiation of premalignant pancreatic intraepithelial neoplasia lesions in mice. To examine cancer stem cell (CSC) functions, floating cultures in plates with a low-attachment surface have been widely employed. CSCs are reported to be able to grow in floating spheres in serum-free culture medium supplemented with epidermal growth factor (EGF) and/or fibroblast growth factor-2 (FGF-2), whereas non-CSCs, more differentiated non-CSCs cannot form spheres. In this study, we examined nestin expression in spheres and clarified whether nestin regulates sphere forming activity. Methods: Human pancreatic ductal adenocarcinoma (PDAC) cell lines, PANC-1, KLM-1, MIAPaCa-2 and PK-45H were used to perform sphere-forming assay in ultra-low attachment plates supplemented with EGF and FGF-2. Expression of CSC markers including CD133, CD44, CD24, epithelial specific antigen (ESA), and nestin in spheres were determined by real time RT-PCR and immunocytochemistry. Sphere-forming cells were dispersed with trypsin, and then cell growth and migration were assessed. Next, short hairpin RNA (shRNA) targeting nestin was stably transfected into PANC-1 and PK-45H, human PDAC cells, which express high levels of nestin, in order to assess the effects of decreased nestin expression on sphere-forming ability. Conversely, KLM-1 cells which express low level of nestin were stably transfected with a nestin expression vector and their sphere forming ability was then determined. Results: All the PDAC cell lines formed spheres, and all CSC markers examined were expressed in the spheres. The sphere cells showed low cell growth rates and increased cell migration as compared to non-sphere cells. Expression levels of nestin in the spheres of PDAC cells were higher than those of non-sphere cells. Nestin shRNA transfected PANC-1 and PK-45H cells showed a marked decrease in sphere number and diameter. By contrast, nestin-gene-transfected KLM-1 cells exhibited increased sphere formation. Conclusion: Nestin is a pancreatic CSC marker that promotes the sphere-forming ability of CSCs. Therefore, nestin may represent a novel therapeutic target for CSCs in PDAC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2457. doi:10.1158/1538-7445.AM2011-2457
Urban Scaling of Football Followership on Twitter (2018)

Social sciences have an important challenge today to take advantage of new research opportunities provided by large amounts of data generated by online social networks. Because of its marketing value, sports clubs are also motivated in creating and maintaining a stable audience in social media. In this paper, we analyze followers of prominent footballs clubs on Twitter by obtaining their home locations. We then measure how city size is connected to the number of followers using the theory of urban scaling. The results show that the scaling exponents of club followers depend on the income of a country. These findings could be used to understand the structure and potential growth areas of global football audiences.
ISOLATION OF ASP TOXIN-PRODUCING NITZSCHIA FROM THAILAND (2008)

Nitzschia navis-varingica is recognized as the major ASP toxin producer other than Pseudo-nitzschia species. Surveys on the distribution and the toxin production of this diatom has been conducted in a few countries in eastern Asia and expanded to Thailand. Eighteen isolates from Thailand showed the positive result for the ASP toxin production is DA and IB, although the ratio of IB was much lower than those of the isolates from southern countries including Okinawa, Japan, the Philippines and Vietnam.
Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal (2009)

Our present findings support the view that nuclear import of IN occurs via the importin alpha pathway and is promoted by a specific NLS domain. This import could be blocked by NLS-IN peptide, resulting in inhibition of viral infection, confirming the view that nuclear import of the viral pre-integration complex is mediated by viral IN.
Probabilistic assessment of Net Transfer Capacity considering forecast uncertainties (2016)

In transmission system planning, researchers propose methods to assess the effect of uncertainties of power system operating condition due to forecasting errors of intermittent generation and loads. In particular probabilistic power flow methods are used to calculate the probability distributions of the voltages and the branch currents, starting from the distributions of power injections/absorptions. These uncertainties play a key role in the operational planning of power systems, as certain configurations of load and intermittent generation can cause security problems. This paper aims to propose a probabilistic methodology to assess Net Transfer Capacity (NTC) among network areas, which quantifies forecast error uncertainties by applying the Point Estimate Method (PEM) combined with Third Order Polynomial Normal (TPN) Transformation. This approach is compared with a conventional NTC assessment technique and has been tested on an IEEE test system.
Corrosion Protection of Copper by a Self‐Assembled Monolayer of Alkanethiol (1997)

A self‐assembled monolayer of 1‐dodecanethiol (DT) was formed on a copper surface pretreated using different methods. The corrosion protection abilities of the monolayer were evaluated in an air‐saturated 0.51 M NaCl solution using various techniques including electrochemical impedance spectroscopy, polarization, coulometry, weight loss, and x‐ray photoelectron spectroscopy. It was found that the corrosion resistance of the monolayer was improved markedly by using a nitric acid etching method. A minimum concentration of M DT was needed to form a protective monolayer. The DT‐monolayer retarded the reduction of dissolved oxygen and inhibited the growth of copper oxide in the NaCl solution. In comparison with other inhibitors, such as benzotriazole (BTA) and mercapto‐benzothiazole (MBT), the DT‐monolayer showed much better corrosion resistance in aqueous solution.
Synthesis and characterizations of quaternary Cu2FeSnS4 nanocrystals (2012)

Quaternary tetragonal Cu(2)FeSnS(4) nanocrystals have been synthesized by a simple hot-injection method. Detailed characterizations have been made. A suitable optical band gap of 1.28 ± 0.02 eV and a notable and stable photoelectrochemical response indicate their potential for application in solar cells.
PRODUCTION OF FUMONISINS AND FUSARINS BY FUSARIUM MONILIFORME FROM (1993)

A liquid culture method for the screening of Fusarium moniliforme for the production of fusarins and fumonisins was used to test strains from Southeast Asia. An analytical method for fumonisins from liquid media was developed after evaluation of five solid phase extraction minicolumns under various conditions. Strains isolated mainly from maize from Indonesia, the Philippines and Thailand produced fusarins A, C and F as well as fumonisins B, and B2. Among the strains, the ratio of fusarins to fumonisins production varied considerably indicating a genetic difference between strains. This is the first report of fumonisins B! and B2 from F. moniliforme from all three countries. Fusarins are reported for the first time from strains from Indonesia and the Philippines.
ChemInform Abstract: Synthesis of Endo or Exo Norbornenic Lactones via Highly Diastereoselective Lactonization of Bicyclic Vinyl Sulfoxides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The role of cross-sectional dispersion in active portfolio management (2017)

We derive and interpret the main results of Modern Portfolio Theory and the Theory of Active Portfolio Management from the perspective that, for active investors, the cross-sectional dispersion of returns is more relevant as a measure of risk than time series volatility. We show that all key measures of portfolio risk - total, systematic and idiosyncratic - are positively related to return dispersion, with dispersion primarily affecting idiosyncratic risk. Moreover, active portfolio returns are a function of managers’ skill and cross-sectional dispersion, with realized dispersion acting as a leverage factor for realized skill. Regardless of their level of skill, however, active managers will tend to reduce their active weights as the cross-sectional dispersion of returns increases. While higher levels of dispersion represent opportunities to earn higher active returns, managers’ information ratios are expected to remain unchanged, as realized tracking error is expected to vary proportionately with dispersion and managers’ active returns. Absolute return investors are therefore more likely to benefit from tactically adjusting the activeness of their strategies with the level of return dispersion.
TECHNICAL COMPARISON OF NINE TREATMENT ALTERNATIVES TO ACHIEVE 0.1 MG/L EFFLUENT PHOSPHORUS (2005)

TECHNICAL COMPARISON OF NINE TREATMENT ALTERNATIVES TO ACHIEVE 0.1 MG/L EFFLUENT PHOSPHORUSThe ability to achieve an effluent having a phosphorus concentration below 0.1 mg/L is becoming increasingly important. Nine alternative technologies that can be considered for these reclamation and reuse applications are developed. A survey of full-scale plants utilizing the developed alternatives is conducted and presented. Both membrane and non-membrane alternatives are compared. The paper...Author(s)A. KleinT. ConstantineG. CrawfordG. DaiggerR. BrauerSourceProceedings of the Water Environment FederationSubjectSession 66: Water Reclamation & Reuse: Technology Evaluation and Irrigation/Groundwater ProtectionDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2005ISSN1938-6478SICI1938-6478(20050101)2005:10L.5508;1-DOI10.2175/193864705783856893Volume / Issue2005 / 10Content sourceWEFTECFirst / last page(s)5508 - 5516Copyright2005Word count99
As diferentes narrativas alimentares do agronegócio (2021)

Frente à ampliação global de problemas de saúde pública relacionados à alimentação, a literatura tem dispensado maior atenção ao estudo das múltiplas determinações que podem influenciar a transição a sistemas agroalimentares sustentáveis e saudáveis. Procurando contribuir com o debate, este artigo analisa as narrativas de diferentes agentes relacionados ao campo do agronegócio sobre duas agendas: a da segurança alimentar e nutricional (SAN) e a da alimentação adequada e saudável. O objetivo é examinar os modos como tais narrativas têm sido mobilizadas e modificadas, tanto para responder a críticas, quanto para legitimar posicionamentos sobre políticas públicas e propostas legislativas. O período abordado corresponde ao intervalo entre os anos 1990 e a década de 2020, e os materiais empíricos utilizados incluem documentos corporativos e estatais, manifestações públicas de agentes privados e políticos, e relatórios de organizações internacionais. Tais materiais são abordados com foco no agenciamento de categorias, nas variações discursivas provocadas pelas críticas e na heterogeneidade de representações do campo. Os resultados mostram que, ao perderem legitimidade quanto à agenda da SAN no país, representações dominantes das cadeias de commodities passam a privilegiar discursos sobre suas contribuições nas exportações desses produtos, ao passo que uma nova controvérsia ganha impulso, aquela que relaciona a alimentação à saúde.
ChemInform Abstract: CYCLOADDITIONEN VON HALOGENSULFONYLISOCYANATEN AN ACETYLENE (1970)

Abstract 2‐Butin (I) reagiert mit Fluorsulfonylisocyanat (II) zu 83% des Uracildisulfofluorids (III), das durch Wasser zu (IV) und weiter zu (V) hydrolysiert wird.
Genome‐wide association studies of the self‐rating of effects of ethanol (SRE) (2019)

The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h<sup>2</sup> : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (r<sub>g</sub> : 0.35-0.76). Genome-wide significant associations were observed (SRE-T: chromosomes 6, rs140154945, COGA-EA P = 3.30E-08 and 11, rs10647170, COGA-AA+EA P = 3.53E-09; SRE-5: chromosome13, rs4770359, COGA-AA P = 2.92E-08). Chromosome 11 was replicated in an EA dataset from the National Institute on Alcohol Abuse and Alcoholism intramural program. In silico functional analyses and RNA expression analyses suggest that the chromosome 6 locus is an eQTL for KIF25. Polygenic risk scores derived using the COGA SRE-T and SRE-5 GWAS predicted 0.47% to 2.48% of variances in AD and DSM-IV AD criterion count in independent datasets. This study highlights the genetic contribution of alcohol response phenotypes to the etiology of alcohol use disorders.
Full wavefield migration, using internal multiples for undershooting (2013)

Full wavefield migration (FWM) is an inversion-based imaging algorithm that utilizes the complete reflection measurements: primaries as well as all multiples, both surface and internal. Using multiples in the imaging can extend the illumination of the subsurface. In this paper we concentrate the study on the internal scattering that can be helpful in imaging structures from below that are otherwise difficult to image by primaries, i.e. an undershooting setting. This can be fruitful in the case of the obstacles, like oil-production facilities, or in the case of poor illumination, like sub-salt imaging or near-surface complexities. We demonstrate such approach on two synthetic examples.
Elemental speciation by liquid chromatography–inductively coupled plasma mass spectrometry with direct injection nebulization (1992)

A new version of the direct injection nebulizer (DIN) is used to interface liquid chromatographic (LC) separations with element-selective detection using inductively coupled plasma mass spectrometry (ICP-MS). The DIN injects all of the sample into the ICP and has a dead volume of less than 1 microliter. Charged species of arsenic and tin are separated as ion pairs on a micro-scale (1 mm i.d.), packed, reversed-phase column. Detection limits are 0.2-0.6 pg for arsenic and 8-10 pg for tin. For methanol + water eluents, the signal is highest at 25% methanol and stays within 25% of this maximum as the methanol fraction is varied from 20 to 80%. Compared with LC-ICP-MS with conventional nebulizers, the absolute detection limits and chromatographic resolution are substantially superior, and the dependence of analyte signal on solvent composition is somewhat less severe with the DIN.
Design of distributed sparse arrays for Lamb wave SHM based upon estimated scattering matrices (2014)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Xin Chen, Jennifer E. Michaels, Thomas E. Michaels; Design of distributed sparse arrays for Lamb wave SHM based upon estimated scattering matrices. AIP Conf. Proc. 18 February 2014; 1581 (1): 248–255. https://doi.org/10.1063/1.4864827 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth (2013)

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy.
The Hilbert Transform (2007)

In this presentation, the basic theoretical background of the Hilbert Transform is introduced. Using this transform, normal real-valued time domain functions are made complex. This yields two useful properties the Envelope and the Instantaneous Frequency. Examples of the practical use of these functions are demonstrated, with emphasis on acoustical applications.
Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and PPh3-Modified RuRh/γ-Al2O3 (2012)

以金鸡纳碱衍生物作为手性修饰剂, 研究了三苯基膦稳定的1.0% Ru+0.2% Rh/γ-Al2O3 催化剂催化芳香酮多相不对称加氢, 考察了修饰剂种类及浓度、碱添加剂种类及浓度、溶剂、氢气压力等因素对不对称加氢反应的影响. 结果表明, 金鸡纳碱衍生物对1.0% Ru+0.2% Rh/γ-Al2O3-tpp 催化剂具有较好的修饰作用, 在优化反应条件下苯乙酮加氢反应的对映选择性高达84%.
Holographic Recording with Limited Laser Light (1971)

Various holographic recording media were compared for conditions of low signal energy densities. The peak value of diffraction efficiency divided by signal-beam exposure (Q) and of normalized contrast ratio divided by signal-beam exposure (A) for Kodak 649 F and for Agfa 8E70, 10E70, and 14C70 were determined. The quantities were optimized with respect to bleaching, hypersensitization, development, and reference beam exposure. Above some value of the reference-to-signal beam ratio these quantities were constant, while their dependence, if any, on the offset angle and signal beamwidth was not determined. The film response was considered in terms of the model T(a) = [b/(b + E(d))] (e) from which Q and A were calculated.
Writing and detecting bits at 100 Gbit/in/sup 2/ in longitudinal magnetic recording media (2000)

We have written bits in longitudinal media at extremely high areal densities, >100, using a focused ion beam (FIB) trimmed write head mounted on a static write/read tester. Bits were written at a track pitch of /spl sim/100 nm and with a 62.5 transition spacing with the same trimmed write head. The bits were characterized with the head read sensor and also with magnetic force microscopy (MFM). The MFM images were analyzed with respect to transition position jitter, signal-to-noise, and track width.
Enantioselective Hydrogenation of α-Aryloxy and α-Alkoxy α,β-Unsaturated Carboxylic Acids Catalyzed by Chiral Spiro Iridium/Phosphino-Oxazoline Complexes (2010)

The iridium-catalyzed highly enantioselective hydrogenation of alpha-aryloxy and alpha-alkoxy-substituted alpha,beta-unsaturated carboxylic acids was developed. By using chiral spiro phosphino-oxazoline ligands, the hydrogenation proceeded smoothly to produce various alpha-aryloxy- and alpha-alkoxy-substituted carboxylic acids with extremely high enantioselectivities (ee up to 99.8%) and reactivities (TON up to 10,000) under mild conditions. The hydrogenation of alpha-benzyloxy-substituted alpha,beta-unsaturated acids provided an efficient alternative for the synthesis of chiral alpha-hydroxy acids after an easy deprotection. A mechanism involving a catalytic cycle between Ir(I) and Ir(III) was proposed on the basis of the coordination model of the unsaturated acids with the iridium metal center. The rationality of the catalytic cycle, with an olefin dihydride complex as the key intermediate, was supported by the deuterium-labeling studies. The X-ray diffraction analysis of the single crystal of catalyst revealed that the rigid and sterically hindered chiral environment created by the spiro phosphino-oxazoline ligands is the essential factor that permits the catalyst to obtain excellent chiral discrimination. A chiral induction model was suggested on the basis of the catalyst structure and the product configuration.
Evaluation of comb-type copolymers with different cationic groups as artificial nucleic acid chaperones (2004)

We have demonstrated that cationic comb-type copolymers (CCCs) accelerate DNA hybridization and increase stability of DNA duplexes and triplexes. The CCCs were considered to act as nucleic acid chaperones that catalyze structural transitions of nucleic acid hybrids. In this study, CCCs with primary amino or guanidino groups were prepared to evaluate the effects of different cationic moieties upon the nucleic acid chaperoning activity. CCCs having guanidino groups have higher accelerating effect on DNA strand exchange reactions (SFRs) than that having primary amino groups. It was suggested that some modes of interactions, such as hydrogen bonding, other than ionic interactions between the copolymers and DNAs may be involved upon the strand exchange activation.
High power excimer laser micromachining (2006)

Today's excimer lasers are well-established UV laser sources for a wide variety of micromachining applications. The excimer's high pulse energy and average power at short UV wavelengths make them ideal for ablation of various materials, e. g., polyimide, PMMA, copper, and diamond. Excimer micromachining technology, driven by the ever-shrinking feature sizes of micro-mechanical and micro-electronic devices, is used for making semiconductor packaging microvias, ink jet nozzle arrays, and medical devices. High-power excimer laser systems are capable of processing large areas with resolution down to several microns without using wet chemical processes. For instance, drilling precise tapered holes and reel-to-reel manufacturing of disposable sensors have proven to be very cost-effective manufacturing techniques for volume production. Specifically, the new industrial excimer laser-the LAMBDA SX 315C-easily meets the high demands of cost-effective production. The stabilized output power of 315 watts at 300 Hz (308 nm) and its outstanding long-term stability make this laser ideal for high-duty-cycle, high-throughput micromachining. In this paper, high-power excimer laser technology, products, applications, and beam delivery systems will be discussed.