gebhart/patrepeval huggingface dataset:
Private Retrieval of POI Details in Top-K Queries (2016)

Location privacy preservation algorithms in the context of location-based services have evolved in the recent years. However, a majority of the proposals assume that points of interests (POI) are ranked only by distance, and demand extensive architectural changes. As a result, a significant gap remains between academic proposals and the industry standard of implementing location based services. Recent advances in mobile device capabilities, more specifically in their computational power and energy efficiency, have opened the possibility of engaging the client hardware more actively in the execution of a privacy algorithm, thereby relaxing strong dependencies on trusted third parties or the service provider. With this motivation, we propose a novel privacy algorithm that determines the most prominent result set through operations restricted to the client device, thereby limiting the communication of precise location information to the service provider. The service provider only acts as a data source, and is required to perform operations that are within existing industry norms. By measuring the privacy offered by the algorithm under a formal threat model, we demonstrate its robustness and practicability, and supplement our conclusions with empirical evidence.
Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics (2022)

The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patients die shortly after diagnosis, and only 6% of patients survive more than 5 years. Moreover, the current average survival of malignant brain tumors is only about 15 months, and the recurrence rate within 2 years is almost 100%. Brain diseases are complicated to treat. The reason for this is that drugs are challenging to deliver to the brain because there is a blood-brain barrier (BBB) protection mechanism in the brain, which only allows water, oxygen, and blood sugar to enter the brain through blood vessels. Other chemicals cannot enter the brain due to their large size or are considered harmful substances. As a result, the efficacy of drugs for treating brain diseases is only about 30%, which cannot satisfy treatment expectations. Therefore, researchers have designed many types of nanoparticles and nanocomposites to fight against the most common malignant tumors in the brain, and they have been successful in animal experiments. This review will discuss the application of various nanocomposites in diagnosing and treating GBM. The topics include (1) the efficient and long-term tracking of brain images (magnetic resonance imaging, MRI, and near-infrared light (NIR)); (2) breaking through BBB for drug delivery; and (3) natural and chemical drugs equipped with nanomaterials. These multifunctional nanoparticles can overcome current difficulties and achieve progressive GBM treatment and diagnosis results.
Mobile agent middleware for mobile computing (2001)

Mobile computing requires an advanced infrastructure that integrates suitable support protocols, mechanisms, and tools. This mobility middleware should dynamically reallocate and trace mobile users and terminals and permit communication and coordination of mobile entities. In addition, open and untrusted environments must overcome system heterogeneity and grant the appropriate security level. Solutions to these issues require compliance with standards to interoperate with different systems and legacy components and a reliable security infrastructure based on standard cryptographic mechanisms and tools. Many proposals suggest using mobile agent technology middleware to address these issues. A mobile agent moves entities in execution together with code and achieved state, making it possible to upgrade distributed computing environments without suspending service. We propose three mobile computing services: user virtual environment (UVE), mobile virtual terminal (MVT), and virtual resource management (VRM). UVE provides users with a uniform view of their working environments independent of current locations and specific terminals. MVT extends traditional terminal mobility by preserving the terminal execution state for restoration at new locations, including active processes and subscribed services. VRM permits mobile users and terminals to maintain access to resources and services by automatically requalifying the bindings and moving specific resources or services to permit load balancing and replication.
Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin (2009)

We examined the effect of prolyl-hydroxyproline (Pro-Hyp), which occurs in human peripheral blood after ingestion of collagen peptide, on the migration and growth of mouse skin fibroblasts. Mouse skin discs were cultured on a 24-well plastic plate in a fetal bovine serum (FBS)-free medium. Addition of Pro-Hyp (200 nmol/mL) significantly increased the number of fibroblasts migrating from the skin to the plate after incubation for 72 h. This effect of Pro-Hyp was abolished by the addition of mitomycin C. The fibroblasts that had migrated from the mouse skin were collected and cultured on collagen gel. The growth of fibroblasts on the collagen gel was suppressed even in the presence of FBS, while rapid fibroblast growth was observed on the plastic plate. Addition of Pro-Hyp (0-1000 nmol/mL) to the medium containing 10% FBS enhanced the growth of fibroblasts on the collagen gel in a dose-dependent manner. These results suggest that Pro-Hyp might stimulate the growth of fibroblasts in the skin and consequently increase the number of fibroblasts migrating from the skin.
Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control (2023)

Host-derived cellular pathways can provide an unfavorable environment for virus replication. These pathways have been a subject of interest for herpesviruses, including the betaherpesvirus human cytomegalovirus (HCMV). Here, we demonstrate that a compound, ARP101, induces the noncanonical sequestosome 1 (SQSTM1)/p62-Keap1-Nrf2 pathway for HCMV suppression. ARP101 increased the levels of both LC3 II and SQSTM1/p62 and induced phosphorylation of p62 at the C-terminal domain, resulting in its increased affinity for Keap1. ARP101 treatment resulted in Nrf2 stabilization and translocation into the nucleus, binding to specific promoter sites and transcription of antioxidant enzymes under the antioxidant response element (ARE), and HCMV suppression. Knockdown of Nrf2 recovered HCMV replication following ARP101 treatment, indicating the role of the Keap1-Nrf2 axis in HCMV inhibition by ARP101. SQSTM1/p62 phosphorylation was not modulated by the mTOR kinase or casein kinase 1 or 2, indicating ARP101 engages other kinases. Together, the data uncover a novel antiviral strategy for SQSTM1/p62 through the noncanonical Keap1-Nrf2 axis. This pathway could be further exploited, including the identification of the responsible kinases, to define the biological events during HCMV replication. <b>IMPORTANCE</b> Antiviral treatment for human cytomegalovirus (HCMV) is limited and suffers from the selection of drug-resistant viruses. Several cellular pathways have been shown to modulate HCMV replication. The autophagy receptor sequestosome 1 (SQSTM1)/p62 has been reported to interact with several HCMV proteins, particularly with components of HCMV capsid, suggesting it plays a role in viral replication. Here, we report on a new and unexpected role for SQSTM1/p62, in HCMV suppression. Using a small-molecule probe, ARP101, we show SQSTM1/p62 phosphorylation at its C terminus domain initiates the noncanonical Keap1-Nrf2 axis, leading to transcription of genes under the antioxidant response element, resulting in HCMV inhibition <i>in vitro.</i> Our study highlights the dynamic nature of SQSTM1/p62 during HCMV infection and how its phosphorylation activates a new pathway that can be exploited for antiviral intervention.
Interactions of macrobicyclic polyethers with ions and ion pairs of picrate salts (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteractions of macrobicyclic polyethers with ions and ion pairs of picrate saltsM. Bourgoin, K. H. Wong, J. Y. Hui, and J. SmidCite this: J. Am. Chem. Soc. 1975, 97, 12, 3462–3467Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ja00845a031https://doi.org/10.1021/ja00845a031research-articleACS PublicationsRequest reuse permissionsArticle Views426Altmetric-Citations224LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Colossal above-room-temperature metal–insulator switching of a Wadsley-type tunnel bronze (2011)

We show evidence of the manifestation of enormous metal-insulator switching ranging up to almost six orders of magnitude in individual nanowires of β'-Cu(x)V(2)O(5). The magnitude and temperature of the phase transition is in strong contrast to data reported over several decades for other Wadsley-type mixed valence tunnel bronze structures.
Register file optimisation (2017)

The increasing demand for low-power solutions and small area usage makes it\nnecessary to explore power efficient solutions for critical parts of a system as the\ndata storage in the register file. The register file is an array of registers capable\nof storing data. This thesis explores two different approaches to optimise the\nregister file.\nThe first approach exploits the regular structure of a register file. By making\na generator that makes relative placement directives, it is possible to place the\ncells of the register file in a regular structure. This is done using a placement\ntool that uses these directives to place the register file cells, instead of letting the\ntool do the placement optimisation.\nThe second approach looks at the architecture of the memory cells of the\nregister file. The selection logic is one-hot encoded and two latch based designs\nare implemented to reduce both power consumption and area usage. Both latch\nbased designs utilises the fact that a flip-flop can be modelled as a pair of a\nmaster latch and a slave latch. By sharing either the slave latches or the master\nlatches, the number of latches needed for the register file is reduced. A Shared\nMaster-latch design and a Shared Slave-latch design are implemented. All the\ndesigns are validated after implementation using existing testbenches designed\nfor the system that the register file is a part of. The designs are synthesized\nand the power consumption are estimated in order to evaluate the optimisation\ncompared to the original, flip-flop based register file.\nThe one-hot encoding of the selection signal proved to reduce the activity of\nthe register file with 38.67 percent, thus reducing the dynamic power consumption\nwith 38.41 percent. The latch based designs further improved the power\nconsumption in the register file, with the Shared Master-latch design most ef-\nficient with an improvement of 53.42 percent on the original design and 24.36\npercent on the one-hot encoded design. The Shared Slave-latch design deemed\nan improvement of 46.75 percent on the original design and 13.55 percent on the\none-hot encoded design.\nIn terms of area usage showed the results that the Shared Slave-latch design\nwas most efficient. Mostly because latches are smaller than flip-flops and that\nthe Shared Master-latch design added extra latches to delay some of the logic. In\nthe end did the Shared Slave-latch design uses 13.93 percent less area than the\noriginal design, and the Shared Master-latch design uses 9.97 percent less. On\nthe other hand, did the area usage increase by 6.66 percent in the design with\nthe one-hot encoded selection logic.
Nitric oxide mediated metallothionein induction by lipopolysaccharide. (1995)

The roles of calcium and/or of the other cellular transduction pathways, and of nitric oxide (NO) on the induction of metallothionein (MT) mRNA by lipopolysaccharide (LPS) has been studied in rat primary cell culture, using inhibitors of protein kinase pathways (H-7, W-7 and TMB-8) and NO production inhibitors (L-NAME, PTIO). LPS exposure led to a rapid increase of MT-mRNA and a peak level revealed 2.5-fold induction as compared to control for 6h incubation at a dose of 3.0 mg/L. A dose of 5.0 and 10.0 mg/L of LPS also provided the same level of MT-mRNA induction. The inhibition of MT induction by LPS was observed with L-NAME, PTIO, but not H-7, W-7. These findings indicate that the alteration of cellular calcium concentration and distribution does not relate to the induction of MT-mRNA by LPS in hepatocytes and that protein kinase C and calmodulin dependent protein kinase pathways have not contributed to MT-mRNA induction by LPS. Finally, the present results show that NO plays an important role in MT induction by LPS.
Enzyme immunoassay of the glycoprotein tropic hormones--choriogonadotropin, lutropin, thyrotropin--with solid-phase monoclonal antibody for the alpha-subunit and enzyme-coupled monoclonal antibody specific for the beta-subunit. (1982)

Monoclonal antibody technology has made it possible to produce homogeneous populations of antibodies to discrete determinants on an antigen surface. We have produced monoclonal antibodies to the alpha-subunit and beta-subunits of the glycoprotein hormones choriogonadotropin, thyrotropin, and lutropin, and developed two-site simultaneous enzyme-linked immunospecific assays for these hormones. The anti-alpha-subunit monoclonal antibody was used as the solid-phase (coated tube) capture antibody for all three hormones; the anti-beta-subunit monoclonal antibodies were coupled to horseradish peroxidase (EC 1.11.1.7). Cross reactions between the closely related choriogonadotropin and lutropin were apparently greater in this method than in RIA, with use of the same antibodies. Ka of the antibodies did not appear to be as critical to sensitivity of the sandwich assay as it was for RIA. The lower limit of detection was 0.2 microgram/L after a 2-h incubation with serum sample at room temperature and a 30-min incubation with enzyme substrate at room temperature after washing away excess enzyme conjugate. Within-assay precision (CV) was very good, less than 6%.
PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses (2023)

A genetic variant in the gene <i>PTPN22</i> (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive T cells to generate <i>PTPN22</i> risk edited (620W), non-risk edited (620R), or knockout T cells from the same donor. <i>PTPN22</i> risk edited cells exhibited increased activation marker expression following non-specific TCR engagement, findings that mimicked <i>PTPN22</i> KO cells. Next, using lentiviral delivery of T1D patient-derived TCRs against the pancreatic autoantigen, islet-specific glucose-6 phosphatase catalytic subunit-related protein (IGRP), we demonstrate that loss of PTPN22 function led to enhanced signaling in T cells expressing a lower avidity self-reactive TCR, but not a high-avidity TCR. In this setting, loss of PTPN22 mediated enhanced proliferation and Th1 skewing. Importantly, expression of the risk variant in association with a lower avidity TCR also increased proliferation relative to <i>PTPN22</i> non-risk T cells. Together, these findings suggest that, in primary human T cells, <i>PTPN22</i> rs2476601 contributes to autoimmunity risk by permitting increased TCR signaling and activation in mildly self-reactive T cells, thereby potentially expanding the self-reactive T cell pool and skewing this population toward an inflammatory phenotype.
Incorporation of 2-methyl-3-hydroxybutyric acid into polyhydroxyalkanoic acids by axenic cultures in defined media (1996)

Alcaligenes eutrophus and Burkholderia cepacia synthesized and accumulated a terpolyester consisting of 3-hydroxybutyric acid, 3-hydroxyvaleric acid, and 2-methyl-3-hydroxybutyric acid (2Me3HB) if the cells were cultivated in a mineral salts medium containing tiglic acid as the sole carbon source or in combination with gluconic acid. The presence of 1–2 mol% of 2Me3HB in the polyester was confirmed by comparison with chemically synthesized methyl ester of 2Me3HB and by nuclear magnetic resonance spectrometry as well as by gas chromatography/mass spectrometry. This is the first report of the incorporation of 2Me3HB by axenic cultures cultivated under defined conditions.
Datasets associated with 'Sucrose diffusion in aqueous solution'. (2016)

The diffusion of sugar in aqueous solution is important both in nature and in technological applications, yet measurements of diffusion coefficients at low water content are scarce. In our paper, “Sucrose diffusion in aqueous sucrose”, we report directly measured sucrose diffusion coefficients in aqueous solution. Using a Raman isotope tracer method, we monitor the diffusion of non-deuterated and deuterated sucrose across a boundary between the two aqueous solutions. As well as providing information of importance to the fundamental understanding of diffusion in binary solutions, these data have technological, pharmaceutical and medical implications, for example in cryopreservation. In the atmosphere, slow organic diffusion may have important implications for aerosol growth, chemistry and evaporation. This dataset contains all raw Raman spectra from which the diffusion coefficients presented in “Sucrose diffusion in aqueous sucrose” are calculated, as well as temperature and humidity data from the hygrometer measuring the conditions under which each experiment was performed.
Angiopoietin-1-expressing adipose stem cells genetically modified with baculovirus nanocomplex: investigation in rat heart with acute infarction (2012)

Abstract: The objective of this study was to develop angiopoietin-1 (Ang1)-expressing genetically modified human adipose tissue derived stem cells (hASCs) for myocardial therapy. For this, an efficient gene delivery system using recombinant baculovirus complexed with cell penetrating transactivating transcriptional activator TAT peptide/deoxyribonucleic acid nanoparticles (Bac-NP), through ionic interactions, was used. It was hypothesized that the hybrid Bac-NP Ang1 system can efficiently transduce hASCs and induces favorable therapeutic effects when transplanted in vivo. To evaluate this hypothesis, a rat model with acute myocardial infarction and intramyocardially transplanted Ang1-expressing hASCs (hASC-Ang1), genetically modified by Bac-NP Ang1 , was used. Ang1 is a crucial pro-angiogenic factor for vascular maturation and neovasculogenesis. The released hAng1 from hASC-Ang1 demonstrated profound mitotic and anti-apoptotic activities on endothelial cells and cardiomyocytes. The transplanted hASC-Ang1 group showed higher cell retention compared to hASC and control groups. A significant increase in capillary density and reduction in infarct sizes were noted in the infarcted hearts with hASC-Ang1 treatment compared to infarcted hearts treated with hASC or the untreated group. Furthermore, the hASC-Ang1 group showed significantly higher cardiac performance in echocardiography (ejection fraction 46.28% ± 6.3%, P < 0.001 versus control, n = 8) than the hASC group (36.35% ± 5.7%, P < 0.01, n = 8), 28 days post-infarction. The study identified Bac-NP complex as an advanced gene delivery vehicle for stem cells and demonstrated its potential to treat ischemic heart disease with high therapeutic index for combined stem cell-gene therapy strategy. Keywords: combined stem cell-gene therapy, baculovirus, nanoparticle, myocardial therapy, angiogenesis, tissue engineering
Acute coronary artery occlusion during and after percutaneous transluminal coronary angioplasty. Frequency, prediction, clinical course, management, and follow-up. (1991)

Acute coronary artery occlusion during PTCA is often unpredictable, but its frequency is higher in patients with unstable angina, multivessel disease, and complex lesions. Despite immediate redilatation, use of intracoronary streptokinase, and emergency bypass surgery, PTCA is associated with a high mortality and morbidity.
Is Hemodiafiltration the Current Golden State? (2015)

This issue is a dedicated supplement published in addition to the regular issues of 'Blood Purification' focussing on one specific topic. 'Blood Purification' is a well-respected, international peer-reviewed journal in nephrology. Supplement issues are included in the subscription.
Tilted birefringent Fabry-Perot etalon for tuning dye lasers (1976)

A tilted birefringent Fabry-Perot etalon, which is set at an angle to the axis of the dye laser cavity and rotated about the normal of end-faces of the etalon, allows the dye laser emission to be tuned with very high finesse as obtained by two cascaded conventional Fabry-Perot etalons.
Life-Threatening Human Metapneumovirus Pneumonia Requiring Extracorporeal Membrane Oxygenation in a Preterm Infant (2004)

We present the first report in the literature of a child with human metapneumovirus pneumonia who required extracorporeal membrane oxygenation for survival. This was a 3-month-old premature boy from British Columbia, Canada, who developed severe respiratory failure, experienced failure of high-frequency oscillatory mechanical ventilation, and required extracorporeal membrane oxygenation support for 10 days. This case illustrates the importance of including this newly discovered pathogen among the causes of childhood pneumonia.
Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs (2013)

Crossover studies are frequently used in clinical research as they allow within-subject comparisons instead of the between-subject evaluation of parallel group designs. Estimation of interesting parameters from such designs is, however, not trivial. We provide three methods for estimating treatment effects and associated standard errors from an AB/BA crossover trial. Assuming at least asymptotic normality, we can obtain the confidence intervals for single parameters as well as for differences or ratios of treatment effects. The latter is particularly useful in a pharmacokinetic context to establish bioequivalence using area under the concentration versus time curves (AUCs). In this work, we will illustrate how Fieller-type confidence intervals can be constructed for the ratio of AUCs estimated using a noncompartmental approach in a sparse sampling setting from a two-treatment, two-period, two-sequence crossover trial. In particular, we will discuss a flexible batch design, which includes traditional serial sampling and complete data designs as special cases. Via simulation, we show that the proposed intervals have nominal coverage and keep the type I error even for small sample sizes. Moreover, we illustrate the methodology in a real data example.