gebhart/patrepeval huggingface dataset:
Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein (1995)

The E5 polypeptide of bovine papillomavirus type 1 is a small membrane-bound protein which induces the transformation of immortalized fibroblasts, apparently via the formation of a ternary complex with the platelet-derived growth factor receptor (PDGFR) and the 16-kDa V-ATPase protein. This interaction seems to be mediated, at least in part, by their respective transmembrane domains. E5 also cooperates with transfected beta PDGFR to induce interleukin-3 (IL-3)-independent growth of a mouse myeloid precursor cell line (32D) which normally lacks expression of most known tyrosine kinase growth factor receptors. Cell proliferation induced by beta PDGFR and E5 is also highly specific, since the highly conserved alpha PDGFR and other related receptors did not physically or functionally interact with E5 in these cells. In the current study, analysis of chimeric alpha and beta PDGFRs confirmed that a short region encompassing the beta PDGFR transmembrane domain was sufficient for complex formation with E5, receptor autophosphorylation, and sustained proliferation of 32D cells in the absence of IL-3. Furthermore, a deletion mutant lacking the entire extracellular domain efficiently bound E5 and induced IL-3-independent growth. These data provide direct evidence that the interaction between E5 and the beta PDGFR involves amino acids 531 to 556 of the receptor transmembrane region and that this specific interaction is critical for activation of the PDGFR signaling complex.
Biocontrol of sclerotinia stem rot ( Sclerotinia sclerotiorum ) of soybean using novel Bacillus subtilis strain SB24 under control conditions (2009)

Sclerotinia stem rot (SSR), caused by Sclerotinia sclerotiorum , is a major disease of soybean in Canada. Laboratory and greenhouse experiments were conducted to evaluate potential effectiveness of cell suspensions, cell‐free culture filtrates and broth cultures of Bacillus subtilis strain SB24 for suppression of SSR. The SB24 cell suspensions and cell‐free culture filtrates significantly reduced mycelial growth of S. sclerotiorum by 50 to 75% and suppressed sclerotial formation by &gt; 90%. The severity on soybean was negatively correlated ( r &lt; −0·84, P &lt; 0·01) to the concentrations of cell suspension, cell‐free culture filtrate and broth culture applied. The cell suspension and broth culture preparations significantly ( P &lt; 0·01) reduced SSR severity by 45 to 90% at concentrations ranging from 5 × 10 6 to 10 9 CFU mL −1 . The most effective concentration was 5 × 10 8 CFU mL −1 for all three preparations, reducing the severity by 60 to 90%. The B. subtilis SB24 was most effective in reducing disease severity when applied ≤ 24 h before plant inoculation with S. sclerotiorum and a significant effectiveness was observed up to 15 days after plant inoculation. The population density of B. subtilis on soybean leaves decreased by 1·5 to 2·5 log units over 15 days under field conditions, and by 0·8 log units over 5 weeks under control conditions. The decrease in population density was significantly correlated with rainfall in the field ( r &lt; −0·93, P &lt; 0·01), suggesting that the biocontrol bacteria may be washed away by rain.
Independent Wheel Effects in Real Time Estimation of Tire-Road Friction Coefficient from Steering Torque (2016)

Improvement of control technologies and increased public acceptance of active systems on vehicles has led to greater implementation of safety critical assistance systems in production vehicles. However, the estimate of tire friction coefficient utilized within these systems is often obtained using only data from inertial sensors in which the tire friction is weakly represented. In contrast, skilled human drivers utilize steering torque to obtain a sense of the surface friction. In theory, this approach can also be utilized with electric power steering or steer-by-wire technologies, but there are significant challenges in obtaining and interpreting data from the steering system including the signal characteristics of steering torque measurements and the well-known problem of practical measurement of tire slip angles. More importantly, a problem often lost in modeling assumptions is in left/right asymmetry of the steering torques. The work presented in this paper illustrates the weak signal-to-noise ratio for steering torque in carefully controlled experiments and demonstrates that the lumped-axle assumption may lead to poor estimates of the front axle peak force value when attempting to predict it at slip angles less than those required for full saturation of both wheels.
Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma (1996)

Oral polyprenoic acid prevents second primary hepatomas after surgical resection of the original tumor or the percutaneous injection of ethanol.
C/EBPalpha and C/EBPbeta are early markers of liver development (2006)

Pancreatic cells can be converted to hepatocytes by overexpression of C/EBPbeta (Shen, C-N, Slack, J.M.W. and Tosh, D., 2000. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology 2: 879-887). This suggested that expression of one or more C/EBP factors may distinguish liver and pancreas in early development. We have now studied the early expression of C/EBPalpha and C/EBPbeta in the mouse embryo and show that both are expressed exclusively in the early liver bud and not in the pancreatic buds. Their expression is identical to that of hepatocyte nuclear factor 4 (HNF4), another key hepatic transcription factor and alpha-fetoprotein (AFP), a differentiation product characteristic of immature hepatocytes. Both are complementary to the early expression of Pdx1, a key pancreatic transcription factor. These results are consistent with the idea that C/EBP factors are master regulators for liver development.
Patient reported sexual concerns in routine cancer care. (2021)

12128 Background: Sexual health is an important component of overall well-being and can be adversely impacted by chemotherapy, surgery, radiation, in addition to the psychological effects of cancer treatments. Sexual health is challenging to discuss and may be overlooked or avoided during cancer care. Methods: Patients presenting for consultation in an outpatient multisite cancer center completed electronic distress screening (EDS) between January 2017 and December 2020. The EDS contains 42 questions; demographic information, cancer symptoms and side effects, and psychosocial factors. The EDS is completed by patients before a clinical encounter for early symptom identification and intervention. We conducted a retrospective data analysis of sexual health concerns (&gt;5; scale 0-10) and evaluated patient characteristics and clinically relevant distress (&gt;4; NCCN Distress Tool), depression risk (&gt;3; PhQ2), and anxiety risk (&gt;3; GAD2). Our primary aim was to identify the prevalence of sexual health concerns. The secondary aim was to examine the relationship between sexual health and emotional well-being. Results: 57,375 EDS screens were completed. 13,950 patients (24%) reported sexual concerns or lack of interest in sex (&gt;5) within the last 2 weeks. The frequency of these concerns at specific clinics ranged from 12% to 48%, with the highest rates at Palliative care (39%) and Psycho-Oncology (48%) clinics. Genitourinary (30%), Gynecologic (27%) and Gastroenterology (26%) reported the highest frequency of sexual concerns from cancer site specific clinics. Males reported a higher rate of sexual problems compared to females (30% vs 21%, p &lt; 0.001), but a lower rate of relationship concern distress (12% vs 13%, p &lt; 0.05). Patients with a risk for depression (n = 9,126) or anxiety (n = 10,809) had higher rates of self-reported sexual concerns than those with a negative screen (44% vs 21% depression, p &lt; 0.001; 40% vs 21% anxiety, p &lt; 0.001). Conclusions: Sexual health is a concern for approximately one-quarter of patients presenting for cancer care. Sexual health concerns were prevalent across cancer sites. Patients with positive screens for anxiety and/or depression have nearly double the rates of reported sexual health concerns. Sexual health is a current unmet need that impacts cancer patients and warrants attention.
Beyond Inferring Class Representatives: User-Level Privacy Leakage From Federated Learning (2018)

Federated learning, i.e., a mobile edge computing framework for deep learning, is a recent advance in privacy-preserving machine learning, where the model is trained in a decentralized manner by the clients, i.e., data curators, preventing the server from directly accessing those private data from the clients. This learning mechanism significantly challenges the attack from the server side. Although the state-of-the-art attacking techniques that incorporated the advance of Generative adversarial networks (GANs) could construct class representatives of the global data distribution among all clients, it is still challenging to distinguishably attack a specific client (i.e., user-level privacy leakage), which is a stronger privacy threat to precisely recover the private data from a specific client. This paper gives the first attempt to explore user-level privacy leakage against the federated learning by the attack from a malicious server. We propose a framework incorporating GAN with a multi-task discriminator, which simultaneously discriminates category, reality, and client identity of input samples. The novel discrimination on client identity enables the generator to recover user specified private data. Unlike existing works that tend to interfere the training process of the federated learning, the proposed method works "invisibly" on the server side. The experimental results demonstrate the effectiveness of the proposed attacking approach and the superior to the state-of-the-art.
Durable long-term survival of adult patients with relapsed B-ALL after CD19 CAR (19-28z) T-cell therapy. (2017)

7008 Background: CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated high initial responses in patients with relapsed B-ALL. However, clinical characteristics associated with the durability of response remain undefined. Herein, we report the results from analysis of our phase I clinical trial of 19-28z CAR T cells in adult patients with relapsed B-ALL (NCT01044069) with a focus to identify those patients who optimally benefit from 19-28z CAR T cell therapy with durable long-term survival and reduced toxicities. Methods: Adults with relapsed B-ALL were infused with autologous T cells expressing the 19-28z CAR following conditioning chemotherapy. Disease burden was assessed by bone marrow biopsy immediately prior to T cell infusion; patients with &lt; 5% blasts were classified as minimal residual disease (MRD) cohort vs. patients ≥5% blasts as morphologic disease cohort. Response assessment occurred at 4 weeks. Median follow-up duration was 18 months (range, 0.2-57.3). Results: 51 adults received 19-28z CAR T cells; 20 in the MRD and 31 in the morphologic cohort. Complete remission (CR) rates were comparable (95% and 77%, respectively). However, median event-free and overall survivals widely diverged among the 42 patients who achieved MRD-negative CR: not reached (NR) (95% confidence interval [CI]: 4.2-NR) vs. 6.3 months (95% CI, 4.8-9.0) (p = 0.0005), and NR (95% CI, 15.3-NR) vs. 17 months (95% CI, 8.5 – 36.2) (p = 0.0189), in the MRD and morphologic cohorts, respectively. Subsequent allogeneic HSCT in either cohort did not improve survival (p = 0.8). MRD cohort patients developed substantially less severe cytokine release syndrome (CRS) and neurotoxicity, both correlating with peak CAR T cell expansion (p = 0.0326 and p = 0.0001, respectively). Conclusions: Despite comparable initial CR rates regardless of pre-treatment disease burden, durability of 19-28z CAR T cell mediated remissions and survival in adult patients with relapsed B-ALL positively correlated to a low disease burden and do not appear to be enhanced by allogeneic transplant. Our findings strongly support the early incorporation of CD19 CAR therapy before morphologic relapse in B-ALL. Clinical trial information: NCT01044069.
Comparison off genetic distance and order off DNA markers in five populations of rice (1996)

A group of about 300 evenly distributed DNA markers from a high density RFLP linkage map of rice constructed using an F2 population derived from a japonica variety, Nipponbare, and an indica variety, Kasalath, were used to evaluate gene order and genetic distance in four other rice mapping populations. The purpose of this study was to determine the degree to which information gained from the high density linkage map could be applied to other mapping populations, particularly with regard to its utility in bridging quantitative traits and molecular and physical mapping information. The mapping populations consisted of two F2 populations derived from Dao Ren Qiao/Fl-1084 and Kinandangputi/Fl-1007, recombinant inbred lines from Asominori/IR24, and a backcross population from Sasanishiki/Habataki//Sasanishiki. All DNA markers commonly mapped in the four populations showed the same linkage groups as in the Nipponbare/Kasalath linkage map with conserved linkage order. The genetic distance between markers among the different populations did not vary to a significant level in any of the 12 chromosomes. The differences in some markers could be attributed to the size of the population used in the construction of the linkage maps. Furthermore, the conservation of linkage order found in the distal region of chromosomes 11 and 12 was also confirmed in the RFLP maps based on the four populations of rice. These suggest that any major genetic information from the Nipponbare/Kasalath map can be expected to be approximately the same in other crosses or populations. This high density RFLP linkage map, which is being utilized in constructing a physical map of rice, can be very useful in interpreting genome structure with great accuracy in other populations. Key words : linkage map, japonica, indica, gene order, genetic distance.
Effect of androstenedione administration on the maternal hypothalamo-pituitary-adreno-placental axis in the pregnant rhesus monkey. (1996)

To assess the interaction among androgens, placenta, and the hypothalamo-pituitary-adrenal axis we studied effects of androstenedione administered intravascularly to the pregnant monkey on maternal plasma CRH, ACTH, dehydroepiandrosterone sulfate (DHEAS), cortisol, and estradiol concentrations. Ten monkeys (128 +/- 3 days gestation; mean +/- SEM) were instrumented under general halothane anesthesia with maternal femoral artery and venous catheters and uterine electromyogram electrodes. At 137-144 days gestation, baseline maternal femoral artery samples for CRH, ACTH, DHEAS, cortisol, and estradiol measurements were taken at 1.5-h intervals for 7 h starting 2 h before darkness. On the following day, a continuous iv androstenedione infusion (0.3 mg/kg.min at 0.25 ml/h) in 10% intralipid was started at 0930 h in four monkeys; the other six animals received vehicle alone at the same rate starting at the same time. Maternal blood sampling was repeated 1 and 3 days after androstenedione or vehicle administration. Maternal plasma CRH, ACTH, DHEAS, cortisol, and estradiol levels were unaffected by intralipid. In contrast, androstenedione infusion produced a sustained increase in maternal plasma estradiol and a sustained fall in maternal plasma ACTH, but did not affect maternal plasma CRH, DHEAS, or cortisol concentrations. These results provide evidence for negative feedback regulation by androgens at the hypothalamo-pituitary-adrenal axis in the pregnant monkey. Lack of inhibition of maternal plasma CRH after androstenedione administration supports differential regulation of hypothalamic and placental CRH by androgens.
Fast Minimax Path-Based Joint Depth Interpolation (2014)

We propose a fast minimax path-based depth interpolation method. The algorithm computes for each target pixel varying contributions from reliable depth seeds, and weighted averaging is used to interpolate missing depths. Compared with state-of-the-art joint geodesic upsampling method which selects the K nearest seeds to interpolate missing depths with O(Kn) complexity, our method does not need to limit the number of seeds to K and reduces the computational complexity to O(n). In addition, the minimax path chooses a path with the smallest maximum immediate pairwise pixel difference on it, so it tends to preserve sharp depth discontinuities better. In contrast to the results of previous depth upsampling algorithms, our approach can provide accurate depths with fewer artifacts.
Out of the shadows - making mental health a global development priority : editorial (2016)

On the 13th and 14th April 2016, stakeholders from the world's community of mental health care advocates met for a two-day conference co-hosted by the World Bank and the World Health Organisation in Washington DC. The aim of the Out of the Shadows: Making Mental Health a Global Development Priority conference was to engage civil society; the business community; financiers; government, NGO and health organizations, and technology innovators to take ownership of the urgent need for investment in mental health services, and the expected returns in terms of health, social and economic benefits.
Studies of gold cluster compounds using high-resolution 31P solid-state nuclear magnetic resonance spectroscopy (1985)

High-resolution 31P n.m.r. spectra of a series of crystalline gold phosphine cluster compounds have been obtained using magic angle sample spinning. The spectra are interpreted on the basis of the known crystal structures, and are compared with corresponding spectra of the compounds in solution. With one exception, the clusters appear to be stereochemically rigid in the crystals at room temperature, although most are fluxional in solution, some even at low temperatures. In many cases separate resonances can be resolved in the solid-state spectra from the distinct phosphine environments of the cluster framework. A combination of solid-state and solution n.m.r. spectroscopy is likely to be extremely valuable in the characterisation of both the structure and dynamics of phosphine-containing cluster compounds.
Late gadolinium enhancement location and transcatheter ablation efficacy in a large cohort of patients affected by myocarditis with arrhythmic manifestation (2020)

Abstract Introduction Myocarditis is a complex inflammatory disease, usually secondary to viral infections or immune system dysregulation, with extremely heterogeneous clinical manifestations. Among them, potentially life-threatening ventricular arrhythmias (VA) may present at any stage of the disease as an expression of myocardial electrical instability. Purpose Our aim was to evaluate the efficacy of radiofrequency catheter ablation (RFCA) of VA in our large cohort of myocarditis, trying to understand the predictors of RFCA success. Methods and results 144 patients (61 men; age 43 [29–54] years) with history of myocarditis with arrhythmic presentation (118 biopsy-proven, 82%) composed our population. At presentation, 26% of patients suffered of ventricular tachycardia (VT) while in 17% cardiac arrest occurred: overall 49 patients (35%) were implanted with an ICD. The median left ventricular ejection fraction (LVEF) was 58% (48–61%). An intensive non-invasive and invasive work-up was performed: 104 patients underwent cardiac magnetic resonance (CMR) that showed late gadolinium enhancement (LGE) in 67 of them (63%). In 37 patients LGE was found in the anteroseptal portion of the left ventricle: this pattern showed association with major arrhythmic relapse (VT and ventricular fibrillation) during follow up (Fig. 1; OR 4.0, CI 95% 1.14–14.1, p=0.03). 95 patients underwent endocardial RFCA, using contact electroanatomic mapping. Interestingly, in patients with anteroseptal LGE RCFA didn't affect significantly the arrhythmic relapse (OR 5, CI 95% 0.9–33, p=0.06). Otherwise RFCA prevent arrhythmic relapse in patients that showed LGE in ventricular portion other than the anteroseptal one (OR 0.027, IC 95% 0.002–0.40, p&amp;lt;0.01). During a median follow-up of 735 days (418–2168) 6 deaths occurred: logistic regression on all-cause death showed LVEF and VT at presentation as the only independent predictors for mortality (p=0.01). Conclusions In myocarditis patients with VA, LGE pattern predicts arrhythmic relapse during follow-up. RFCA success rate is strictly linked to scar location, being significantly higher in patients with non-anteroseptal LGE. Figure 1 Funding Acknowledgement Type of funding source: None
Effect of histone-H2A (H-H2A), platelet activating factor (PAF) and pregnancy specific protein B (PSPB) on secretion of prostaglandins E and F2 alpha (PGE; PGF2 alpha) by bovine endometrium and H-H2A on basal secretion of luteinizing hormone (LH) by bovine pituitary cells in vitro. (1996)

Effects of H-H2A, PSPB or PAF on day 16 bovine endometrial secretion of PGE and PGF2 alpha and H-H2A on basal secretion of LH by bovine pituitary cells in vitro were examined in two experiments. PAF (P < or = 0.08) and H-H2a + PAF (P < or = 0.10) treatment for two hours in an in vitro perfusion system tended to increase secretion of PGF2 alpha expressed as a proportion of the prechallenge concentrations of PGF2 alpha by day 16 bovine caruncular endometrium, which occurred during the two-hour period after treatment removal. PGF2 alpha was increased (P < or = 0.02) in the two hour period after the treatment was removed in both control and H-H2A-treated endometrium. H-H2A (P < or = 0.07) and PSPB (P < or = 0.08) tended to increase PGE, while H-H2A + PSPB (P < or = 0.05) and H-H2A + PAF (P < or = 0.03) increased secretion of PGE expressed as a proportion of the prechallenge concentrations of PGE by day 16 bovine caruncular endometrium during the challenge and postchallenge treatment periods, but did not differ (P < or = 0.05) between the two-hour challenge period and the two-hour postchallenge period after removal of the treatment. In experiment two, H-H2A decreased (P < or = 0.05) basal secretion of LH by bovine pituitary cells in vitro. These data suggest that H-H2A and PSPB preferentially stimulate secretion of PGE by bovine endometrial tissue and may play a role in maternal recognition of pregnancy, while PAF increased PGF2 alpha secretion. In addition, H-H2A may play a role in regulating secretion of LH by the pituitary. Key words: Pregnancy Specific Protein B, Histone-H2A, Prostaglandin E and F2 alpha, Platelet Activating Factor, Endometrium, Cow.
From Giant Vesicles to Filaments and Wires: Templates for Conducting Polymers (2004)

Conducting polypyrrole‐coated structures with lengths of several hundreds of micrometers and diameters varying from several micrometers to less then 150 nm have been formed using biomembrane templates (see Figure). The nanotubes can be attached between Au electrode surfaces, and are stable for at least a month. Possible applications exist in the fabrication of electronic devices, inter‐element wiring, and biosensors.