gebhart/patrepeval huggingface dataset:
BMS-181184, a new pradimicin derivative screening, taxonomy, directed biosynthesis, isolation and characterization. (1993)

BMS-181184 is a new semisynthetic pradimicin derivative with a broad-spectrum antifungal activity. In a search for actinomycetes producing BMS-181184, 4 strains of Actinomadura sp. isolated from soil samples were found to produce the antibiotic under conditions of directed biosynthesis. Among them, Actinomadura sp. AB1236 proved most useful in the production of BMS-181184 when fermented in a medium containing D-serine and D-cycloserine. A minor product isolated from the broth of strain AB1236 was identified as the dexylosyl analog of BMS-181184, which was also obtained by acid hydrolysis of BMS-181184.
Einkommensentwicklung und Konsumverhalten älterer Menschen in Deutschland (2011)

Die Seniorenwirtschaft gehört weltweit zu den Branchen mit den größten Zuwachsraten. Auch in Deutschland wird der demographische Wandel immer mehr als Herausforderung für Politik, Wirtschaft und Wissenschaft verstanden.
Effective Passivation of the Low Resistivity Silicon Surface by a Rapid Thermal Oxide/PECVD Silicon Nitride Stack and Its Application to Passivated Rear and Bifacial Si Solar Cells (2008)

Presented at the 2nd World Conference on Photovoltaic Solar Energy Conversion; Vienna, Austria; July 6-10, 1998.
Cardiovascular disease: risk factors, secular trends, and therapeutic guidelines. (1998)

A brief review of cardiovascular disease incidence and risk factors for coronary heart disease and cardiac failure is presented. Secular trends in cardiovascular disease risk factors, morbidity, and mortality are a major focus. Declines in cardiovascular disease mortality over the past 30 yr, a more modest decline in coronary heart disease, and an increase in cardiac failure are demonstrated. Emphasis is placed on evidence from large-scale, prospective, observational and interventional studies, and the pertinent U.S. guidelines and recommendations for care are provided. Consideration is given to the major risk factors, including lipids, blood pressure, smoking, and diabetes mellitus. Additional information is also given concerning the role of vitamins, homocysteine metabolism, and left ventricular hypertrophy. Although this review focuses on commonly accepted risk factors in the general population, where appropriate, specific information that is relevant to patients with chronic renal disease is provided.
Syndecan-3 as a Novel Biomarker in Alzheimer’s Disease (2022)

Early diagnosis of Alzheimer's disease (AD) is of paramount importance in preserving the patient's mental and physical health in a fairly manageable condition for a longer period. Reliable AD detection requires novel biomarkers indicating central nervous system (CNS) degeneration in the periphery. Members of the syndecan family of transmembrane proteoglycans are emerging new targets in inflammatory and neurodegenerative disorders. Reviewing the growing scientific evidence on the involvement of syndecans in the pathomechanism of AD, we analyzed the expression of the neuronal syndecan, syndecan-3 (SDC3), in experimental models of neurodegeneration. Initial in vitro studies showed that prolonged treatment of tumor necrosis factor-alpha (TNF-α) increases SDC3 expression in model neuronal and brain microvascular endothelial cell lines. In vivo studies revealed elevated concentrations of TNF-α in the blood and brain of APPSWE-Tau transgenic mice, along with increased SDC3 concentration in the brain and the liver. Primary brain endothelial cells and peripheral blood monocytes isolated from APPSWE-Tau mice exhibited increased SDC3 expression than wild-type controls. SDC3 expression of blood-derived monocytes showed a positive correlation with amyloid plaque load in the brain, demonstrating that SDC3 on monocytes is a good indicator of amyloid pathology in the brain. Given the well-established role of blood tests, the SDC3 expression of monocytes could serve as a novel biomarker for early AD detection.
Continuous‐variable quantum information processing (2009)

Abstract Observables of quantum systems can possess either a discrete or a continuous spectrum. For example, upon measurements of the photon number of a light state, discrete outcomes will result whereas measurements of the light's quadrature amplitudes result in continuous outcomes. If one uses the continuous degree of freedom of a quantum system for encoding, processing or detecting information, one enters the field of continuous‐variable (CV) quantum information processing. In this paper we review the basic principles of CV quantum information processing with main focus on recent developments in the field. We will be addressing the three main stages of a quantum information system; the preparation stage where quantum information is encoded into CVs of coherent states and single‐photon states, the processing stage where CV information is manipulated to carry out a specified protocol and a detection stage where CV information is measured using homodyne detection or photon counting.
Vancomycin: Aerosolization (2004)

Off-Label Drug Uses This Hospital Pharmacy feature is extracted from Off-Label DrugFacts, a quarterly publication available from Facts and Comparisons. Off-Label DrugFacts is a practitioner-oriented resource for information about specific FDA-unapproved drug uses. This new guide to the literature will enable the health care professional/clinician to quickly identify published studies on off-label uses and to determine if a specific use is rational in a patient care scenario. The most relevant data are provided in tabular form so that the reader can easily identify the scope of information available. A summary of the data—including background, study design, patient population, dosage information, therapy duration, results, safety, and therapeutic considerations—precedes each table of published studies. References direct the reader to the full literature for more comprehensive information prior to patient care decisions. Direct questions or comments on “Off-Label Drug Uses” to hospitalpharmacy@drugfacts.com .
The origin and evolution of lignin biosynthesis (2010)

Lignin, a phenolic polymer derived mainly from hydroxycinnamyl alcohols, is ubiquitously present in tracheophytes. The development of lignin biosynthesis has been considered to be one of the key factors that allowed land plants to flourish in terrestrial ecosystems. Lignin provides structural rigidity for tracheophytes to stand upright, and strengthens the cell wall of their water-conducting tracheary elements to withstand the negative pressure generated during transpiration. In this review, we discuss a number of aspects regarding the origin and evolution of lignin biosynthesis during land plant evolution, including the establishment of its monomer biosynthetic scaffold, potential precursors to the lignin polymer, as well as the emergence of the polymerization machinery and regulatory system. The accumulated knowledge on the topic, as summarized here, provides us with an evolutionary view on how this complex metabolic system emerged and developed.
Immunization of Adults (1993)

In the United States, the immunization of adults does not receive the same priority as the immunization of children, although deaths from vaccine-preventable diseases occur predominantly in adults. About 50,000 to 70,000 adults die each year from pneumococcal infection, influenza, or hepatitis B (Table 1),1 as compared with about 1000 children who die from diseases targeted by childhood immunizations. Reasons for the poor record of immunization of adults include lingering doubts on the part of both the public and health care providers about the efficacy and safety of vaccines; uncertainty about specific recommendations; concern about liability; inadequate reimbursement; and poorly . . .
Services for Battered Women (1984)

Counseling, case management and advocacy services for battered women seeking legal aid broaden their resources and options for dealing with abuse. Findings from a demonstration project specify the range of needs and services mobilized to effectively aid these women with the major life adjustments they and their children face.
Supp Figure 3 continued from Involvement of Epigenetics and EMT-Related miRNA in Arsenic-Induced Neoplastic Transformation and Their Potential Clinical Use (2023)

&lt;p&gt;Supp Figure 3 continued&lt;/p&gt;
The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity (1997)

The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level.
High doses of intravenous Ig inhibit in vitro uptake of C4 fragments onto sensitized erythrocytes (1991)

We have recently reported that intravenous Ig (IVIg) inhibits uptake of activated C3 fragments onto antibody-sensitized red blood cells (RBCs). To elucidate the mechanism by which IVIg exerts its effect on the complement system, we examined the possible interference with the C4 step of the classical complement cascade. We examined the capacity of autologous serum containing high concentrations of human IVIg to deposit C4 fragments onto model targets (guinea pig and/or human erythrocytes sensitized with rabbit anti-guinea pig/human erythrocytes IgG antibody). C4 binding was quantified with radiolabeled anti-C4. Guinea pig serum with added IVIg suppressed C4 uptake onto IgG-sensitized guinea pig erythrocytes at all time points (0, 5, 15, and 30 minutes). Using sera of guinea pigs treated with increasing doses of IVIg, this effect was shown to be dose-responsive. Serum from a patient treated with IVIg showed reduced C4 uptake onto sensitized homologous RBCs. In comparison with the serum from the same patient before IVIg therapy was administered, levels were decreased almost to background. C4 functional titers in those two samples were not different. C3 uptake was studied in parallel with C4 to compare the degree of inhibition using sera with increasing doses of IVIg in both the human and guinea pig system. C3 and C4 inhibition curves completely overlapped. Our findings suggest that IVIg is an effective inhibitor of deposition of early complement activation products (C4b, C3b) onto target surfaces and may indicate interference of IVIg with multiple sites of complement activation.
Comment on 'Is there a glassy phase transition in two dimensions?' (1990)

For original paper see Baran et al. ibid., vol.22, p.L855 (1989). Use of the random sequential adsorption (RSA) model to investigate the existence of metastable and glassy phases is discussed. It is argued that, in its simple version, the RSA model is not appropriate for studying such phases. Improved versions are suggested.
Leukotriene B/sub 4/ (LTB/sub 4/) induces formation of inositol-phosphates (IP's) in rat peritoneal polymorphonuclear leukocytes (PMN's) (1986)

LTB/sub 4/ induced rapid breakdown of prelabeled inositol-phospholipids (PI) in rat PMN. Formation of (/sup 3/H)-inositol-trisphosphate ((/sup 3/H)-IP/sub 3/) was rapid, with a peak of 250-300% of the control level, after 5-15 sec of stimulation with LTB/sub 4/. Accumulation of (/sup 3/H)-inositol-bisphosphate ((/sup 3/H)-IP/sub 2/) was rapid, peaking after 30 sec of stimulation. (/sup 3/H)-inositol-monophosphate ((/sup 3/H)-IP/sub 1/) accumulated gradually in the presence of LiCl. The kinetics of (/sup 3/H)-IP/sub 3/, (/sup 3/H)-IP/sub 2/ and (/sup 3/H)-IP/sub 1/ accumulation suggested that LTB/sub 4/ may interact with receptors in PMNs, activate phospholipase C which, in turn, induces hydrolysis of PI. The agonist activities of several LTB/sub 4/ analogs were employed to investigate the structure activity relationship of LTB/sub 4/ receptor mediated activation of PI hydrolysis. Increases in (/sup 3/H)-IP/sub 3/ formation were dependent upon the concentration of LTB/sub 4/ and the agonist analogs. The rank order potency of these analogs were equivalent to that of the pharmacological activity of LTB/sub 4/ agonists in the chemotaxis assay. Furthermore, the Islet activation protein (IAP) inhibited LTB/sub 4/ induced (/sup 3/H)-IP/sub 3/ formation. The tumor promoting phorbomyristate ester also inhibited LTB/sub 4/ induced (/sup 3/H)-IP/sub 3/ formation. These results suggest LTB/sub 4/ may interactmore » with receptors in rat PMNs, activate G/sub i/ protein regulated phospholipase C and induce (/sup 3/H)-IP/sub 3/ formation.« less
Adaptive rake combining in the soft handover region (2008)

We propose and analyze new finger assignment schemes which are applicable for RAKE reception in the soft handover region. These schemes rely on variants of the conventional generalized selection combining (GSC) and the minimum selection GSC schemes in order to choose an acceptable base station and its corresponding paths. Relying on some recently derived results on order statistics, we investigate the average error rate performance as well as the average number of estimated and combined paths of the proposed schemes over independent and identically distributed Rayleigh fading channels. The mathematical formalism is illustrated with few selected numerical results that show the tradeoff between performance and processing power consumption.
A modular instrument for exploring the mechanics of cardiac myocytes (2007)

The cardiac ventricular myocyte is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. Millions of primary myocytes, which remain viable for 4-6 h, can be readily isolated from animal models. However, currently available instrumentation allows the mechanical properties of only a few physically loaded myocytes to be explored within 4-6 h. Here we describe a modular and inexpensive prototype instrument that could form the basis of an array of devices for probing the mechanical properties of single mammalian myocytes in parallel. This device would greatly increase the throughput of scientific experimentation and could be applied as a high-content screening instrument in the pharmaceutical industry. The instrument module consists of two independently controlled Lorentz force actuators-force transducers in the form of 0.025 x 1 x 5 mm stainless steel cantilevers with 0.5 m/N compliance and 360-Hz resonant frequency. Optical position sensors focused on each cantilever provide position and force resolution of <1 nm/ radicalHz and <2 nN/ radicalHz, respectively. The motor structure can produce peak displacements and forces of +/-200 mum and +/-400 microN, respectively. Custom Visual Basic.Net software provides data acquisition, signal processing, and digital control of cantilever position. The functionality of the instrument was demonstrated by implementation of novel methodologies for loading and attaching healthy mammalian ventricular myocytes to the force sensor and actuator and use of stochastic system identification techniques to measure their passive dynamic stiffness at various sarcomere lengths.
Melanoma cancer stem cells (2009)

Cutaneous melanoma is among the most aggressive types of human cancer, and if untreated, virtually every melanoma has the potential to metastasize. While patients with locoregional disease and low tumor thickness can be cured in 90% of cases by surgery, the majority of patients with advanced disease die because of the inefficiency of current therapy regimens.
Exploring strongly correlated quantum many‐body systems with ultracold atoms in optical lattices (2010)

Abstract Ultracold quantum gases in optical lattices can be used as novel model system for the exploration of strongly correlated many‐body phases of bosonic or fermionic particles. Here we report on the realization of metallic, Mott‐insulating and band insulating phases in ultracold spin mixtures of fermionic 40 K atoms. The experimental results are compared to ab initio dynamical mean field theory (DMFT) calculations.
Modified taxols. 5. Reaction of taxol with electrophilic reagents and preparation of a rearranged taxol derivative with tubulin assembly activity (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModified taxols. 5. Reaction of taxol with electrophilic reagents and preparation of a rearranged taxol derivative with tubulin assembly activityGamini Samaranayake, Neal F. Magri, Chote Jitrangsri, and David G. I. KingstonCite this: J. Org. Chem. 1991, 56, 17, 5114–5119Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://doi.org/10.1021/jo00017a024RIGHTS & PERMISSIONSArticle Views631Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (764 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
It Makes Sense: A Wide-Coverage Word Sense Disambiguation System for Free Text (2010)

ACL 2010 - 48th Annual Meeting of the Association for Computational Linguistics, Proceedings of the Conference
Therapeutic and Chemopreventive Actions of a Novel Polyamine Analog Against Breast Cancer (2000)

Abstract : The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence work has focused on development of inhibitors of this metabolic pathway, particularly diethylnorspermine (DENSpm). In the first year a phase II trial of DENSpm for women with advanced breast cancer has enrolled nine women. Response analysis is in progress and no excessive toxicity has been observed. Collection of DENSpm- and control-treated breast cancer tissues derived from discarded mastectomy tissues has begun and 23 pairs that are potentially suitable for analysis have been stored; collection continues. Proposed testing of DENSpm in animal models has been delayed because of our move to a new building with new animal facilities in the middle of the first year and a current concern about whether the cell line proposed is contaminated in some way. It is expected that they will begin shortly. Proposed chemoprevention studies are expected to begin in the second year as initially stated.
Interference Characterization in Wireless Networks: A Determinantal Learning Approach (2019)

Owing to its tractability, stochastic geometry (SG) has recently gained immense popularity for the modeling and analysis of wireless networks. However, given their simplicity, the state-of-the-art SG-based models are not well-equipped to capture complex interactions that exist in actual wireless networks. On the other hand, this problem of modeling interactions in actual data patterns has been explored in machine learning (ML) community from different perspectives. In particular, the idea of determinantal point process (DPP) from SG is used extensively in ML to solve a general class of subset selection problems with diversity. Since subset selection also arises naturally in wireless networks, the DPP learning (DPPL) framework can be leveraged to develop a new class of learning-enabled analytical models using SG. In this paper, we explore this idea through a case study. In particular, we use the DPPL framework for characterizing the interference distribution in a wireless local area network (WLAN) with carrier sense multiple access (CSMA) where a subset of the transmitters (Tx-s) are active in a given time instant. In particular, we model the locations of the active Tx-s as a DPP and learn its distribution from a sequence of network realizations. Numerical results demonstrate that our analytical characterization of interference based on DPP learning (DPPL) is remarkably accurate.
Smart Setup and Accelerometer Mounting Check for Vibration Measurements (2016)

This paper describes some of the challenges experienced by many experimentalists and presents new ways of overcoming these. The Smart Setup can dramatically reduce the time required for the test setup and the presented Accelerometer Mounting Check procedure can check the transducer’s health and the integrity of the whole measurement channel. The goal is to get the data right first time and in the shortest possible time.
Immunological characterization of a 17-kDa antigen fromCryptosporidium parvumrecognized early by mucosal IgA antibodies (1992)

Cryptosporidium parvum antigens were characterized by immunoblot analysis of sera and intestinal secretions of BALB/c mice orally infected with 10(5) oocysts. A major band at 17 kDa under non-reduced conditions and at 18 kDa under reduced conditions was recognized by anti-C. parvum IgA and IgG in serum and intestinal secretions from day 15 post-infection. This recognition persisted throughout the experiment (day 30). Mouse-serum antibodies raised against the 17-kDa purified antigen (P17) showed no cross-reactivity with other C. parvum antigens. Immunofluorescence study revealed that this antigen is located on the sporozoite. It is suggested that this antigen could be a good candidate for studies of mucosal immune response to C. parvum and for vaccination.