gebhart/patrepeval huggingface dataset:
Gaullistes dans l’Ouest atlantique (2013)

Les terres de la façade atlantique, des franges méridionales de la frontière pyrénéenne aux bordures maritimes de la Manche, sont au début de la Cinquième République marquées à droite. Le gaullisme trouvera dans ces six régions du grand Ouest atlantique (Aquitaine, Poitou-Charentes, Pays de la Loire, Bretagne, Basse-Normandie et Haute-Normandie) un ancrage électoral majoritaire pendant les premières législatures (1958-1981). En outre, ces régions accueillent de grandes figures du mouvement gaulliste : Olivier Guichard, Jacques Chaban-Delmas, Jean Foyer, Yvon Bourges, Robert Boulin, Vincent Ansquer, Robert Buron, etc., autant de personnalités, souvent ministres, grands élus locaux, qui ont pu, durant les vingt premières années du régime, jouer un rôle central dans la vie politique tant locale que nationale. Cet ouvrage cherche à mieux cerner, par une analyse d’histoire électorale, la profondeur de cet ancrage politique. Les auteurs se sont interrogés sur l’implantation et la durabilité du gaullisme dans ces régions plutôt attachées en 1958 aux cultures politiques de droite, à une époque où leur hégémonie dans le pays est peu contestée par une gauche affaiblie et qui ne se recomposera qu’au cœur des années 1970. Les conclusions montrent que le gaullisme y pénètre de façon inégale et ne peut empêcher le basculement à gauche de la Bretagne, ou de certains départements, notamment dans les deux régions les plus méridionales. Son implantation y est donc partielle, parfois de circonstances. La France de l’Ouest en 1981 n’est plus une terre de droite, elle y conserve des bastions, mais elle connaît un rééquilibrage politique durable, que les auteurs cherchent ici à comprendre et à expliquer.
Wild plant pathosystems (2013)

The conference, held in the historical city of Olomouc (
Numerical simulation of semiconductor devices: energy-transport and quantum hydrodynamic modeling (2002)

In this paper, the authors discuss two modern semiconductor models: the energy-transport and the quantum hydrodynamic equations. The energy-transport models consist of the conservation laws for mass and energy for the electrons, coupled self-consistently to the Poisson equation. The quantum hydrodynamic equations consist of the conservation laws for mass, momentum and energy, including the Poisson equation.
Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome (2020)

Dubowitz syndrome (DubS) is considered a recognizable syndrome characterized by a distinctive facial appearance and deficits in growth and development. There have been over 200 individuals reported with Dubowitz or a "Dubowitz-like" condition, although no single gene has been implicated as responsible for its cause. We have performed exome (ES) or genome sequencing (GS) for 31 individuals clinically diagnosed with DubS. After genome-wide sequencing, rare variant filtering and computational and Mendelian genomic analyses, a presumptive molecular diagnosis was made in 13/27 (48%) families. The molecular diagnoses included biallelic variants in SKIV2L, SLC35C1, BRCA1, NSUN2; de novo variants in ARID1B, ARID1A, CREBBP, POGZ, TAF1, HDAC8, and copy-number variation at1p36.11(ARID1A), 8q22.2(VPS13B), Xp22, and Xq13(HDAC8). Variants of unknown significance in known disease genes, and also in genes of uncertain significance, were observed in 7/27 (26%) additional families. Only one gene, HDAC8, could explain the phenotype in more than one family (N = 2). All but two of the genomic diagnoses were for genes discovered, or for conditions recognized, since the introduction of next-generation sequencing. Overall, the DubS-like clinical phenotype is associated with extensive locus heterogeneity and the molecular diagnoses made are for emerging clinical conditions sharing characteristic features that overlap the DubS phenotype.
<title>Residual stress contribution to fracture of ferroelectric ceramics</title> (1996)

Experiments based on the Vicker's indentation technique are applied to a ferroelectric and a relaxor composition of lead lanthanum zirconate titanate. When polarized, the ferroelectric composition displays anisotropic crack growth. The anisotropy in crack growth is affected by electric field. Increasing the electric field increases the crack growth perpendicular to the field direction. The relaxor composition displays nearly isotropic crack growth even under electric field. Application of electric field slightly hinders crack growth perpendicular to the field. As the field level is increased, this effect diminishes. The effect appears to be related to intergranular residual stress.
Ultra wideband Bistatic Forward Scattering Inverse Synthetic Aperture Radar imaging (2011)

In this work Bistatic Inverse Forward Scattering Inverse Synthetic Aperture Radar (BFISAR) concept is addressed. Geometric description of BFISAR topology with stationary transmitter and receiver, and moving target is given. Kinematic vector equations are derived. Mathematical model of BFISAR signal with linear frequency modulation (LFM) is described. It is proved that BFISAR signal formation and image reconstruction can be interpreted as direct and inverse projective operation respectively. Through Taylor expansion of the projective operator basic image reconstruction procedures, including phase correction, Fourier transform range compression and Fourier transform azimuth compression are defined. Numerical experiment to verify mathematical models derived is carried out.
Planar Manipulation of an Object by Unmanned Aerial Vehicles Using Sliding Modes (2020)

Enabling a team of unmanned aerial vehicles (UAVs) to cooperate and perform tasks collaboratively is a challenging problem. In this paper, sliding-mode-based collaborative maneuvering strategies are developed for a pair of UAVs moving on a two-dimensional plane and carrying a rigid payload. Such strategies are apt for applications such as payload delivery, where the 2-UAV system has to interact with either a stationary or a maneuvering platform. The strategies are designed using the concept of nonsingular terminal sliding mode and a kinematics-based formulation of interaction between the 2-UAV system and a point on the platform. The strategies enable the 2-UAV system to track the maneuvering platform and deliver the payload to the platform from any angle, within a finite-time interval. In addition, the maneuvering strategies also include a controller so that the payload can be oriented to a desired angle. These strategies are then generalized, using the concept of collision cones, to scenarios where the payload is to be delivered to within a region on the platform, rather than to a point.
Spin-valve sensors with domain control hard magnet layers (1995)

We have fabricated unshielded narrow-track NiFe/Cu/NiFe/FeMn spin-valve sensors with a height of 2 /spl mu/m and a track-width of less than 2 /spl mu/m using CoCrPt hard magnets (4/spl pi/Mr=5500 G, Hc=1000 Oe) as a domain control layer. Barkhausen noise was completely suppressed by a longitudinal biasing field from the CoCrPt layers. The bias state was improved by applying a strong ferromagnetic exchange coupling field of 30 Oe between the free and pinned NiFe layers through a 14 /spl Aring/-thick Cu interlayer. We have also fabricated shielded CoCrPt magnet-biased spin-valve read heads with a track-width of 1.7 /spl mu/m. The heads had no Barkhausen noise and very low crosstalk noise.
ChemInform Abstract: Acid‐Base Properties and Catalytic Activity of Metal‐Organic Frameworks: A View from Spectroscopic and Semiempirical Methods (2016)

Abstract Review: 313 refs.
Proprioception more impaired distally than proximally in subjects with hemispheric dysfunction (2000)

Holmes noted that with hemispheric injuries proprioceptive disturbances were more marked in the distal than proximal limb segments and proposed that this difference was related to the size of cortical sensory representations. An alternative hypothesis is that sensation from distal segments projects to the contralateral hemisphere and sensation from proximal segments projects to both hemispheres. Selective hemispheric anesthesia was used to test these alternative hypotheses and revealed a decrement in distal but not proximal proprioception with hemispheric anesthesia, thereby supporting the bilateral projection hypothesis.
Association Plots: Visualizing associations in high-dimensional correspondence analysis biplots (2020)

S ummary In molecular biology, just as in many other fields of science, data often come in the form of matrices or contingency tables with many measurements (rows) for a set of variables (columns). While projection methods like Principal Component Analysis or Correspondence Analysis can be applied for obtaining an overview of such data, in cases where the matrix is very large the associated loss of information upon projection into two or three dimensions may be dramatic. However, when the set of variables can be grouped into clusters, this opens up a new angle on the data. We focus on the question which measurements are associated to a cluster and distinguish it from other clusters. Correspondence Analysis employs a geometry geared towards answering this question. We exploit this feature in order to introduce Association Plots for visualizing cluster-specific measurements in complex data. Association Plots are two-dimensional, independent of the size of data matrix or cluster, and depict the measurements associated to a cluster of variables. We demonstrate our method first on a small data set and then on a genomic example comprising more than 10,000 conditions. We will show that Association Plots can clearly highlight those measurements which characterize a cluster of variables.
Hodgkin's lymphoma in the elderly: a different disease in patients over 60. (2007)

With improved prognosis for patients with Hodgkin's lymphoma (HL), interest has increasingly focused on high-risk groups such as elderly patients. Advanced age at presentation is still one of the strongest negative risk factors. Many different factors influence the prognosis in elderly patients. These include biologic differences such as more aggressive histology, different distribution of disease, more frequent diagnosis of advanced stage, and shorter history of disease. In addition, however, aging itself and associated factors such as comorbidity, reduced tolerability of conventional therapy, more severe toxicity and treatment-related deaths, failure to maintain dose intensity, shorter survival after relapse, and death due to other causes contribute to the poorer outcome in elderly patients. Besides the evaluation of specific causes and risk factors, this review highlights recent and ongoing studies for elderly patients with HL as well as international approaches and recommendations for this age group.
[Isolation and properties of the acid carboxypeptidase of Aspergillus oryzae]. (1976)

Caboxypeptidase with pH optimum 4--5 for peptide substrates is isolated from "oryzine", the enzyme mixture produced by Aspergillus oryzae, by means of successive salt fractionation, Sephadex G-75 gel filtration, chromatography on amberlite IRC-50, hydroxylapatite, DEAE-cellulose and polyacrylamide gel electrophoresis. Its molecular weight, as determined by means of polyacrylamide gel electrophoresis in the presence of sodium dolecylsulphate, was found to be 37 000. The enzyme has a broad substrate specificity and does not possess dipeptidase and esterase activities. Acid carboxypeptidase from Asp. oryzae is not a metalloenzyme, it is inactivated by specific inhibitors of serine proteases and by compounds blocking SH-groups. The enzyme is suggested to contain functionally important serine and cysteine residues and to be acid carboxipeptidase.
High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture (2021)

Human pluripotent stem cells harbor an unlimited capacity to generate therapeutically relevant cells for applications in regenerative medicine. However, to utilize these cells in the clinic, scalable culture systems that activate defined receptors and signaling pathways to sustain stem cell self-renewal are required; and synthetic materials offer considerable promise to meet these needs. <i>De novo</i> development of materials that target novel pathways has been stymied by a limited understanding of critical receptor interactions maintaining pluripotency. Here, we identify peptide agonists for the human pluripotent stem cell (hPSC) laminin receptor and pluripotency regulator, α<sub>6</sub>-integrin, through unbiased, library-based panning strategies. Biophysical characterization of adhesion suggests that identified peptides bind hPSCs through α<sub>6</sub>-integrin with sub-μM dissociation constants similar to laminin. By harnessing a high-throughput microculture platform, we developed predictive guidelines for presenting these integrin-targeting peptides alongside canonical binding motifs at optimal stoichiometries to generate nascent culture surfaces. Finally, when presented as self-assembled monolayers, predicted peptide combinations supported hPSC expansion, highlighting how unbiased screens can accelerate the discovery of targeted biomaterials.
First Results after Introduction of the Four-Armed da Vinci Surgical System in Fully Robotic Laparoscopic Cholecystectomy (2005)

Fully robotic laparoscopic cholecystectomy is safe and feasible but seems more expensive and time consuming at this moment.
Super-resolution imaging using saturated absorption combined with spatial frequency modulated Imaging (Conference Presentation) (2020)

In recent years, we demonstrated a new approach to super-resolution microscopy based on driving a nonlinear interaction with a Spatial Frequency Modulated Imaging (SPIFI). SPIFI is a line imaging technique that linearly sweeps all the frequencies supported by the band-pass of the objective lens. Here we introduce a new method of unrestricted super-resolution imaging based on driving saturated absorption in the specimen excitation. The saturated absorption drives harmonic distortions of the spatial frequencies used to illuminate the sample. These harmonics manifest themselves as temporal harmonic frequencies allowing for easy detection and separation of the super-resolution information in the far field.
Failure-free genetic algorithm optimization of a system controller using SAFE/LEARNING controllers in tandem (2003)

The paper presents a method for failure-free genetic algorithm optimization of a system controller. Genetic algorithms present a powerful tool that facilitates producing near-optimal system controllers. Applied to such methods of computational intelligence as neural networks or fuzzy logic, these methods are capable of combining the non-linear mapping capabilities of the latter with learning the system's behavior directly, that is, without a prior model. At the same time, genetic algorithms routinely produce solutions that lead to the failure of the controlled system. Such solutions are generally unacceptable for applications where safe operation must be guaranteed. We present here a method of design, which allows failure-free application of genetic algorithms through utilization of SAFE and LEARNING controllers in tandem, where the SAFE controller recovers the system from dangerous states while the LEARNING controller learns its behavior. The method has been validated by applying it to an inherently unstable system, an inverted pendulum.
CREATIVE INTELLIGENCE (A Psychological and Sociological Perspective) (2016)

Intelligence has been defined in many ways but most often it was consociated with a cognitive capability of a special kind. Intelligence cooperates with the abilities of various spheres of the human psychic. Therefore, the term “intelligence” is broad in its range, and on that account different types of intelligence are being distinguished: cognitive (abstract), verbal, social, emotional, cultural, and creative. The name of intelligentsia is also used to denote a social class which members support themselves by engaging in mental labour. Nowadays, the name “intelligentsia” is used to denote people working on positions requiring higher education. We use the word to describe people who occupy themselves with creative mental labour.
Effectiveness of reactive sputter-deposited Ta–N films as diffusion barriers for Ag metallization (2004)

Tantalum nitride films on silicon were prepared by reactive sputtering of Ta under nitrogen partial flow rates varying from 15% to 40% N2. Rutherford backscattering spectroscopy (RBS) and x-ray diffraction (XRD) analysis revealed that the composition and phases of the Ta–N films were influenced by the N2 flow rate. Increasing the nitrogen partial flow rate from 25% to 40% N2, results in the films changing from metal-rich to stoichiometric Ta–nitride. High N2 flow rates (30%–40% N2) resulted in a disordered tantalum–nitride. The tantalum nitride films were evaluated as potential diffusion barriers for Ag metallization. Sheet resistance measurements, XRD and RBS analysis confirmed that Ta–N films, used as diffusion barriers in the Ag∕Ta–N∕Si system, were thermally stable up to 650°C when annealed for 30min in vacuum. The thermal stability was independent of N2 flow rate within this temperature range. However, at 700°C, the barrier failed as a result of Ta–silicide formation by reaction with the underlying Si substrate, and dewetting of Ag on Ta–N occurred.
Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. (1993)

Two major physiological roles for the pineal hormone melatonin (MEL) have been identified in vertebrates: the hormone influences circadian rhythmicity and regulates seasonal responses to changes in day length. These effects of MEL are thought to be due to interaction with specific, high affinity MEL receptors in the suprachiasmatic nucleus (SCN) and hypophysial pars tuberalis (PT), respectively. Using the ligand 2-[125I]iodo-MEL ([125I]MEL), we examined putative MEL receptors in these regions in human and monkey tissue specimens by in vitro autoradiography. Specific, high affinity [125I]MEL-binding sites (Kd, 53.3 +/- 13.0 pM) were consistently observed in the human SCN. In contrast, specific [125I]MEL binding was detectable in the PT of only one of the eight human specimens examined. Specific [125I]MEL binding was also detected in the pars distalis of several subjects, but with an inconsistent distribution. In rhesus monkey tissue, MEL receptors were readily detected in the SCN and, as in all other seasonally breeding species examined to date, in the PT. The relative absence of MEL receptors from the human PT suggests that neuroendocrine responses to MEL in humans may occur by fundamentally different mechanisms than those that underlie the photoperiodic regulation of reproduction in seasonally breeding species.
Learning from Post-Editing: Online Model Adaptation for Statistical Machine Translation (2014)

Using machine translation output as a starting point for human translation has become an increasingly common application of MT.We propose and evaluate three computationally efficient online methods for updating statistical MT systems in a scenario where post-edited MT output is constantly being returned to the system: (1) adding new rules to the translation model from the post-edited content, (2) updating a Bayesian language model of the target language that is used by the MT system, and (3) updating the MT system's discriminative parameters with a MIRA step.Individually, these techniques can substantially improve MT quality, even over strong baselines.Moreover, we see super-additive improvements when all three techniques are used in tandem.
Identification of the DC-SIGN-Interactive Domains on the Envelope Glycoprotein of HIV-1 CRF07_BC (2010)

DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain on the gp120 of CRF07_BC. Pseudotyped viruses containing single (N233Q, N275Q, N330Q, N351Q, N355Q, N381Q, and N387Q), double (N233Q + N275Q, N233Q + N351Q, N275Q + N351Q), or triple (N233Q + N275Q + N351Q) N-glycan mutant gp120 were generated. Capture assays showed that the DC-SIGN-binding capacity of pseudoviruses with N275Q or N351Q decreased significantly. Rabbit antisera against synthetic peptides covering the N275 (R72 antiserum) or N351 (R77 antiserum) region blocked the interaction between wild-type gp120 and DC-SIGN in the capture assay. Furthermore, pseudotype viruses containing gp120 from five different CRF07_BC isolates were generated and R72 and R77 antisera blocked their interactions with DC-SIGN (80% for R72 and 40% for R77, respectively) in the capture assays. In conclusion, the N275 and N351 glycan sites on the CRF07_BC gp120 play an important role in mediating the interaction between gp120 and DC-SIGN. This information is valuable for developing both therapeutic and preventive agents for HIV-1 infection.
Therapeutic Inhibition Of Retinoblastoma By Nanoceria (2012)

Purpose:Retinoblastoma is a cancer of the developing retina that initiates during fetal development. In a separate unpublished study, we have found that retinoblastomas are under oxidative stress accompanied by the production of reactive oxygen species (ROS) (M.A.D., unpublished). Spontaneous production of ROS by malignant cells can associate with upregulation of vascular endothelial growth factor (VEGF) and initiation of angiogenesis, which sustains tumor growth. Nanoceria are antioxidant cerium oxide nanoparticles unique in their ability to regeneratively and catalytically scavenge ROS. When engineered into nanoparticles 3-5nm in size, nanoceria are characterized by an enhanced surface area to volume ratio and an increased ability to participate in redox reactions mimicking the activity of the endogenous cellular defense mechanisms of superoxide dismutase and catalase. Our lab has previously shown that nanoceria are capable of decreasing ROS and inhibiting neovascularization in an animal model of heritable retinal degeneration. We hypothesize that in vivo treatment with nanoceria during tumorigenesis will result in downregulation of VEGF, inhibition of angiogenesis, and decreased tumor growth in a mouse model of heritable retinoblastoma. Methods:SJRBL-8 cells mouse retinoblastoma cells were incubated with increasing concentrations of nanoceria (1nM-1mM) for 24, 48, and 72 hours to determine whether or not nanoceria affect proliferation of retinoblastoma cells. We also performed intravitreal injections of nanoceria (172 ng/eye) in P53TKO mice (Chx10-cre; Rb ; p53 ; P107) following tumor onset. Live animal imaging, histology, and molecular analysis including PCR array were used to assess changes in tumor growth and cytokine signaling. Results:Our data suggest that nanoceria are effective inhibitory agents in a mouse model of retinoblastoma, resulting in decreased tumor growth in vivo as well as decreased cell proliferation in vitro. Conclusions:Based on these data we propose that nanoceria represent a novel anti-cancer therapeutic approach which may be effective as a monotherapy or an as an adjunct to standard chemotherapeutic modalities.
Suppl Figure S4 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S4: Neocuproine is a copper-dependent ROS inducer&lt;/p&gt;