gebhart/patrepeval huggingface dataset:
Bolus injection of human UII in conscious rats evokes a biphasic haemodynamic response (2004)

A biphasic cardiovascular response to bolus i.v. injection of human urotensin II (hUII, 3 nmol kg(-1)) in conscious, male, Sprague-Dawley (SD) rats was identified and underlying mechanisms were explored. Initially (0-5 min) there was tachycardia, hypotension and mesenteric and hindquarters vasodilatation; later (30-120 min), tachycardia, hindquarters vasodilatation and a modest rise in blood pressure occurred. Pretreatment with indomethacin or N(G) nitro-l-arginine methylester (l-NAME) reduced the mesenteric vasodilator response to hUII, and abolished the late tachycardia and hindquarters vasodilatation. Indomethacin also abolished the hypotension and early hindquarters vasodilatation, and substantially reduced the initial tachycardia. Indomethacin and l-NAME together prevented all haemodynamic responses to hUII. Inhibition of inducible NOS had no effect on responses to hUII, whereas inhibition of neuronal NOS reduced the delayed tachycardic response to hUII but did not significantly affect the vasodilatation. Only the initial tachycardic response to hUII was antagonised by propranolol. In spontaneously hypertensive rats (SHR), the initial haemodynamic responses to hUII were qualitatively similar to those in SD rats, although there was also a modest renal vasodilatation. The secondary response comprised a smaller tachycardia and a small rise in blood pressure, with no significant hindquarters vasodilatation. Haemodynamic responses to hUII were not enhanced by endothelin and angiotensin receptor antagonism in either SD rats or in SHRs. One interpretation of these results is that the primary response to bolus injection of hUII is prostanoid- or prostanoid- and NO-mediated (mesenteric vasodilatation) and that this triggers secondary events, which are dependent on eNOS (hindquarters vasodilatation) and neuronal NOS (tachycardia).
Femtosecond laser processing induced low loss waveguides in multicomponent glasses (2017)

We have investigated that femtosecond laser induced optical waveguides in AF32 and in Borofloat-33 glasses. Type-I positive and type-II negative refractive index change mechanisms were established in AF32 and in Borofloat-33 glass waveguides, respectively. Lowest propagation loss of 1.1 ± 0.31 dB/cm could be attained in AF32 glass, which has a typically higher index change than in Borofloat-33 glass. Resultant losses are directly correlated with densification and non-bridging oxygen hole centers, which can be authenticated by Raman and photoluminescence studies.
Natural history of nonhuman primates after conjunctival exposure to Ebola virus (2023)

Transmission of Ebola virus (EBOV) primarily occurs via contact exposure of mucosal surfaces with infected body fluids. Historically, nonhuman primate (NHP) challenge studies have employed intramuscular (i.m.) or small particle aerosol exposure, which are largely lethal routes of infection, but mimic worst-case scenarios such as a needlestick or intentional release, respectively. When exposed by more likely routes of natural infection, limited NHP studies have shown delayed onset of disease and reduced mortality. Here, we performed a series of systematic natural history studies in cynomolgus macaques with a range of conjunctival exposure doses. Challenge with 10,000 plaque forming units (PFU) of EBOV was uniformly lethal, whereas 5/6 subjects survived lower dose challenges (100 or 500 PFU). Conjunctival challenge resulted in a protracted time-to death compared to i.m. Asymptomatic infection was observed in survivors with limited detection of EBOV replication. Inconsistent seropositivity in survivors may suggest physical or natural immunological barriers are sufficient to prevent widespread viral dissemination.
A superfamily of S locus-related sequences in Arabidopsis: diverse structures and expression patterns. (1994)

Six sequences that are closely related to the S gene family of the largely self-incompatible Brassica species have been identified in self-fertilizing Arabidopsis. The sequences define four genomic regions that map to chromosomes 1 and 3. Of the four functional genes identified, only the previously reported Arabidopsis AtS1 gene was expressed specifically in papillar cells and may function in pollination. The remaining three genes, including two novel genes designated ARK2 and ARK3, encode putative receptor-like serine/threonine protein kinases that are expressed predominantly in vegetative tissues. ARK2 promoter activity was detected exclusively in above-ground tissues, specifically in cotyledons, leaves, and sepals, in correlation with the maturation of these structures. ARK3 promoter activity was detected in roots as well as above-ground tissues but was limited to small groups of cells in the root-hypocotyl transition zone and at the base of lateral roots, axillary buds, and pedicels. The nonoverlapping patterns of expression of the ARK genes and the divergence of their sequences, particularly in their predicted extracellular domains, suggest that these genes perform nonredundant functions in specific aspects of development or growth of the plant body.
Oxidation Kinetics of Some Nickel‐Based Superalloy Foils and Electronic Resistance of the Oxide Scale Formed in Air Part I (1999)

Haynes 230, Inconel 625, Inconel 718, and Hastelloy X foil specimens were oxidized in air for several thousand hours in the temperature range of 800‐1100°C. The oxidation kinetics of alloys studied obeyed the parabolic rate law. Haynes 230 exhibited the slowest oxidation kinetics of the alloys studied. X‐ray diffraction, scanning electron microscopy, and electron probe microanalysis (EPMA) were the principal characterization tools employed. Chromium oxide, , was the predominant oxide phase in the oxide scale of all alloys studied. Manganese chromite was also detected in the oxide scales of Haynes 230, Hastelloy X, and Inconel 625. EPMA showed that the concentration of Mn in the oxide scale was much higher than in the alloy, indicating selective oxidation of Mn. The electronic resistance of the oxide scale was measured in air at temperatures up to 800°C on samples oxidized in air for up to several thousand hours. The oxide scale on Haynes 230 exhibited the lowest area‐specific resistance, consistent with its slower oxidation kinetics. © 1999 The Electrochemical Society. All rights reserved.
Second-order motion conveys depth-order information (2004)

Psychophysical and neurophysiological studies have revealed that the visual system is sensitive to both "first-order" motion, in which moving features are defined by luminance cues, and "second-order" motion, in which motion is defined by nonluminance cues, such as contrast or flicker. Here we show psychophysically that common types of second-order stimuli provide potent cues to depth order. Although motion defined exclusively by nonluminance cues may be relatively rare in natural scenes, the depth-order cues offered by second-order stimuli arise ubiquitously as a result of occlusion of one moving object by another. Our results thus shed new light on the ecological importance of second-order motion. Furthermore, our results imply that visual cortical areas that have been shown to be responsive to second-order motion may be extracting information not just about object motion as has been assumed, but also about the relative depth of objects.
The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. (1996)

Brain MR imaging showed infarction/ischemia in the absence of a recognized cerebrovascular accident in 13% of patients. The prevalence of these lesions did not increase significantly between the ages of 6 and 14 years, suggesting that lesions are present by age 6. However, the increase in the average number of lesions per patient with age may indicate progressive brain injury.
Digital Microfluidics With Pressure-Based Actuation (2013)

One of the key issues in biosensors is the time it takes for biomolecules in a solution to reach and bind to the sensor surface (particularly in low-concentration analytes). We present a novel flow scheme without microfluidic channels for label-free biosensors to decrease the delivery time of biomolecules. Through designing the biosensor in such a way that it becomes a membrane with holes, we can apply a droplet on it and push or pull it through the membrane by means of a pressure difference. Contrary to traditional microfluidics for, e.g., flow cells where the analyte flows over the sensor, the flow is now directed through the sensor. We have implemented this scheme in silicon-on-insulator biosensors and have demonstrated in a first proof-of-principle experiment, an improvement in delivery time of at least a factor of three.
Ipsilateral shoulder pain after thoracotomy surgery (2007)

These findings suggest that, irrespective of the effects of the two drug classes at a synaptic level, the dynamics of transient neuronal assemblies are modified selectively by anaesthetics and not analgesics.
Necrotic Oophoritis in Gilts Associated with Experimental Inoculation of a Viral Gene-deletion Mutant Pseudorabies Vaccine (1997)

Previous work on the reproductive effects of various herpesviruses has demonstrated adverse effects on reproductive function in several host species. Although herpesviral vaccines are used in several species to ameliorate the clinical effects of infection, pathogenicity for reproductive tissue, associated with diminished reproductive efficiency, has been reported to be retained in a live-attenuated vaccine strain of the herpesvirus, bovine herpesvirus-1. The objective of this study was to determine if a gene-deletion mutant, thymidine kinase negative, pseudorabies virus retained acute pathogenicity for the reproductive tract of swine following intravenous inoculation during estrus. Estrous cycles of nulliparous gilts were synchronized by administration of a gonadotropin and daily exposure to a boar. During estrus, six gilts were inoculated intravenously with twice the recommended intramuscular dose of a commercially available viral gene-deletion mutant pseudorabies vaccine. Six control gilts in estrus were sham inoculated intravenously with vaccine diluent during estrus. All animals were euthanatized 10 days postinoculation, and the ovaries and uterus were collected for histopathology following gross examination. All reproductive tracts were grossly normal. Histologically, four of six treated gilts had a mild to moderate, multifocal, necrotizing oophoritis, with the lesions limited to corpora lutea and the adjacent stroma. Ovaries of control gilts exhibited to necrotizing lesions. Both control and pseudorabies vaccine-inoculated gilts had occasional minimal focal mononuclear infiltrates in the ovaries. These data show that live attenuated viral gene-deletion mutant pseudorabies vaccine administered to swine during estrus can result in acute pathogenicity in ovarian corpora lutea. No endocrinologic data is available in these pigs, so the impact on pregnancy maintenance is unknown.
Effect of Dietary Chitin on Cholesterol Absorption and Metabolism in Rats. (1992)

The effect of chitin at the level of 5% in the diet on cholesterol absorption and metabolism was studied in Wistar rats fed on diet containing beef tallow (7%) and cholesterol (1%). When compared with pair-fed controls, rats fed on diet containing chitin had: (1) similar weight gain and feed efficiency, (2) lower apparent protein digestibility, (3) equivalent liver steatosis, (4) reduced levels of liver triglycerides and cholesterol, (5) similar levels of serum and fecal cholesterol, (6) higher excretion of triglycerides in feces.
Concurrent radiation therapy and chemotherapy in the treatment of primary squamous cell carcinoma of the vulva (1995)

Concurrent radiation therapy and chemotherapy with local excision performed as needed, appears to be a reasonable alternative to radical vulvectomy in patients with primary squamous cell carcinoma of the vulva. Radical surgery remains a viable option for patients in whom primary therapy has failed.
Roles of DNA adenine methylation in host–pathogen interactions: mismatch repair, transcriptional regulation, and more (2009)

The DNA adenine methyltransferase (Dam methylase) of Gammaproteobacteria and the cell cycle-regulated methyltransferase (CcrM) methylase of Alphaproteobacteria catalyze an identical reaction (methylation of adenosine moieties using S-adenosyl-methionine as a methyl donor) at similar DNA targets (GATC and GANTC, respectively). Dam and CcrM are of independent evolutionary origin. Each may have evolved from an ancestral restriction-modification system that lost its restriction component, leaving an 'orphan' methylase devoted solely to epigenetic genome modification. The formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature. As a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Well-known examples include binding of the replication initiation complex to the methylated oriC, recognition of hemimethylated GATCs in newly replicated DNA by the MutHLS mismatch repair complex, and discrimination of methylation states in promoters and regulatory DNA motifs by RNA polymerase and transcription factors. In recent years, Dam and CcrM have been shown to play roles in host-pathogen interactions. These roles are diverse and have only partially been understood. Especially intriguing is the evidence that Dam methylation regulates virulence genes in Escherichia coli, Salmonella, and Yersinia at the posttranscriptional level.
Circadian Disorders (2011)

Circadian rhythms are near-24 h cycles that exist in all living organisms. Examples in humans include the core body temperature rhythm, hormonal secretion rhythms, and the sleep/wake cycle. Lung function and heart rate also demonstrate circadian rhythmicity in that they cycle daily even in the absence of external influence [1, 2]. The master clock which regulates and coordinates the body’s many rhythms is the suprachiasmatic nucleus (SCN) of the anterior hypothalamus [3]. The molecular machinery in the SCN neurons that generates and perpetuates the circadian rhythm consists of clock gene products which autoregulate their own expression through a complex system of transcriptional, translational, and post-translational processes [4].
Comparative performance of anaerobic filters at mesophilic and thermophilic temperatures (1992)

Anaerobic filters were operated at mesophilic and thermophilic temperatures with hydraulic retention times (HRTs) of 12, 24, and 48 hours over a COD loading range from 2.75 g/L/day to 49.5 g/L/day (172 to 3 090 lb/1 000 cu ft/day). The purpose of the research was to determine the effect of HRT and organic (COD) loading as independent variables. Results indicated that the mesophilic systems were more sensitive to HRT than were the thermophilic systems, with significant decreases in performance of the mesophilic systems with decreases in HRT. The thermophilic reactors showed virtually no reduction in performance with decreased HRT. The increase in organic load produced a reduction in removal efficiency at all HRTs for the mesophilic reactors
Dynamic behaviour of the H-mode in ASDEX upgrade (1994)

The dynamic behaviour of the L-H transition in ASDEX Upgrade is described. We focus on two dynamic phenomena: Dithering Cycles and ELMs. The Dithering Cycles are characterized experimentally; then, a theoretical model is presented which explains the cycle as a limit cycle oscillation at the transition. With regard to ELMs, the modulation of heat and particle fluxes into the divertor due to ELMs is studied, quantitative results from thermography of the target plates are given.
Prostatic Diseases and Male Voiding Dysfunction Prostatic-specific Antigen Velocity After Holmium Laser Enucleation of the Prostate: Possible Predictor for the Assessment of Treatment Effect Durability for Benign Prostatic Hyperplasia and Detection of Malignancy (2009)

In the benign group, the mean PSA dropped from 5.44 to 0.91 ng/mL (P 0.001). The prostate cancer patients who were newly discovered in the follow-up period had significantly higher baseline PSA (P .032) and significantly lower PSA reduction than that of the benign group (75.39% vs 47.49%, P .001). PSAV was calculated by 3 different methods and produced identical results; however, linear regression method produced significantly lower estimates at 7 years. In the malignant group, the mean PSAV at 1 and 3 years was higher than that of the benign group (1.28 vs 0.13 and 2.4 vs 0.09, P 0.022, 0.001, respectively). CONCLUSIONS HoLEP results in a significant reduction in PSA that remained at lower levels during follow-up, suggesting that the glandular size reduction after HoLEP is durable. Monitoring of PSAV is important in long-term follow-up of patients for prostatic carcinoma detection after prostatic surgery. UROLOGY 74: 1105‐1110, 2009. © 2009 Elsevier Inc.
A Reconfigurable Carrier Leakage Canceler for UHF RFID Reader Front-Ends (2010)

This paper presents a new reconfigurable carrier leakage canceler for UHF RFID readers, using a directional coupler and an impedance tuning circuit to improve the sensitivity of the receiver. The impedance tuning circuit, which consists of electrically tunable passive components, can be adaptively tuned to have an optimum reflection coefficient for carrier leakage cancellation. In order to secure the good carrier leakage cancellation performance over the wide operating frequency band, PIN and varactor diodes are used as a variable resistor and a capacitor, respectively, for the impedance tuning circuit. The implemented reconfigurable carrier leakage canceler exhibits more than 65 dB of carrier leakage cancellation over a wide frequency band of 100 MHz, from 860 to 960 MHz when the control voltages of the PIN and varactor diodes are adjusted. As a result, a 15 dB improvement of receiver sensitivity, and 30% improvement of the recognition range have been achieved, respectively, using commercial RFID tags.
The Conformation of Thermoresponsive Polymer Brushes Probed by Optical Reflectivity (2016)

We describe a microscope-based optical setup that allows us to perform space- and time-resolved measurements of the spectral reflectance of transparent substrates coated with ultrathin films. This technique is applied to investigate the behavior in water of thermosensitive polymer brushes made of poly(N-isopropylacrylamide) grafted on glass. We show that spectral reflectance measurements yield quantitative information about the conformation and axial structure of the brushes as a function of temperature. We study how parameters such as grafting density and chain length affect the hydration state of a brush, and provide one of the few experimental evidences for the occurrence of vertical phase separation in the vicinity of the lower critical solution temperature of the polymer. The origin of the hysteretic behavior of poly(N-isopropylacrylamide) brushes upon cycling the temperature is also clarified. We thus demonstrate that our optical technique allows for in-depth characterization of stimuli-responsive polymer layers, which is crucial for the rational design of smart polymer coatings in actuation, gating, or sensing applications.
Formulation and characterization of the microencapsulated entomopathogenic fungus Metarhizium anisopliae MA126 (2008)

Bioinsecticides are expected to be used for controlling major species of aphids. The present study explored a liquid phase coating technique for the formulation of microencapsulated conidia of the entomopathogenic fungus Metarhizium anisopliae MA126. Various parameters for microencapsulation were investigated. The biopolymers sodium alginate, hydroxypropyl methyl cellulose (HPMC) and chitosan were tested as coating materials. Calcium chloride was used as the cross-linking agent for converting soluble sodium alginate into an insoluble form. To improve the efficiency of microencapsulation, the additives of HPMC, dextrin, chitosan or HPMC/chitosan in various ratios (1 : 1, 1 : 3 and 3 : 1) were used as the coating materials. The particle size of a bare microcapsule was less than 30 microm. Larger size microcapsules were produced using vortex method by comparison with that using homogenization method. The latter method, however, was easy to scale up. The effect of coating materials on the morphology and encapsulation efficiency of the microcapsules was also studied. The best encapsulation efficiency (78%) was using HPMC as the additive of the coating material. The next was dextrin (70%). By measuring the germination rate, the results showed that the activity was approximately 80% of the initial after 6 months of storage at 4 degrees C, while that of the bare conidia was less than 50% stored in identical conditions.
Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization (2000)

The subcellular localization of the transcription factor NFATc is tightly regulated by the calcium-regulated phosphatase calcineurin, which acts to directly dephosphorylate NFATc, causing its rapid translocation from the cytoplasm to the nucleus. The calcineurin-mediated nuclear localization of NFATc is opposed by poorly defined protein kinases that act either to directly antagonize nuclear import or, alternatively, to promote nuclear export. Here, we provide evidence that the cellular protein kinases JNK, ERK, p38, and CK2 (formerly casein kinase II) are involved in the regulation of NFATc subcellular localization. We show that JNK, ERK, and p38 physically associate with the NFATc N-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating NFATc subcellular localization, namely Ser(172) and the conserved NFATc Ser-Pro repeats. Moreover, we found that overexpression of JNK, ERK, or p38 is able to block ionomycin-induced NFATc nuclear translocation, whereas treatment of cells with both PD98059 and SB202190, which inhibit MAPK/SAPK signaling pathways, is sufficient to trigger NFATc nuclear localization. Finally, we show that CK2 also binds the N terminus of NFATc and phosphorylates functionally important amino acid residues, including a conserved amino acid motif located downstream of each of the NFATc Ser-Pro repeats that appears to be important for regulating NFATc nuclear export. Collectively, these studies identify functionally important amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization.
Supplementary Figure 5 from Imaging of Human Lymph Nodes Using Optical Coherence Tomography: Potential for Staging Cancer (2023)

Supplementary Figure 5 from Imaging of Human Lymph Nodes Using Optical Coherence Tomography: Potential for Staging Cancer
64Cu-Labeled Triphenylphosphonium and Triphenylarsonium Cations as Highly Tumor-Selective Imaging Agents (2007)

This report presents synthesis and evaluation of the 64Cu-labeled triphenylphosphonium (TPP) cations as new radiotracers for imaging tumors by positron emission tomography. Biodistribution properties of 64Cu-L1, 64Cu-L2, 64Cu-L3, and 99mTc-Sestamibi were evaluated in athymic nude mice bearing U87MG human glioma xenografts. The most striking difference is that 64Cu-L1, 64Cu-L2, and 64Cu-L3 have much lower heart uptake (<0.6% ID/g) than 99mTc-Sestamibi ( approximately 18% ID/g) at >30 min p.i. Their tumor/heart ratios increase steadily from approximately 1 at 5 min p.i. to approximately 5 at 120 min p.i. The tumor/heart ratio of 64Cu-L3 is approximately 40 times better than that of 99mTc-Sestamibi at 120 min postinjection. Results from in vitro assays show that 64Cu-L1 is able to localize in tumor mitochondria. The tumor is clearly visualized in the tumor-bearing mice administered with 64Cu-L1 as 30 min postinjection. The 64Cu-labeled TPP/TPA cations are very selective radiotracers that are able to provide the information of mitochondrial bioenergetic function in tumors by monitoring mitochondrial potential in a noninvasive fashion.