gebhart/patrepeval huggingface dataset:
A study on building of a common gateway for secure exchange and transmission of electronic business message (2007)

Purpose To present a research model attempting to build an innovative common gateway complaint with Rosettanet Standards for the secure message exchange between electronic businesses under this age of internet economy. The use of Rosettanet Standards is to achieve the effectiveness and efficiency of message exchange and consequently gain mutual benefits by means of agile response for cross‐organizational co‐operation. Design/methodology/approach The common service gateway is modeled by taking the advantages of transmission comply with the standard model specified by RosettaNet among business trading partners involved in supply chain system. A prototyping system compliant with the model presented is built and installed as a gateway interface of digital firms and seamlessly integrate to the firm's backend information system to conduct the message exchange with its business trading partners. The prototype is also implemented to prove the feasibility and effectiveness of this proposal of innovative model. Findings Through the practical experiment, the service model provided can really assist the firms using this service gateway to conduct its peer trading partners with having same gateway installed may streamline their flow of business data and create a higher value of supply chain between them in terms of communication and operation costs. Research limitations/implications More experiments and trials of the prototyping system need to be conducted in different test cases in order to make a concrete conclusion of this paper. Practical implications The adoption of international standard model is easier to implement a supply chain system and the business value is also can be achieved if the electronic data exchange is carried over the internet. Originality/value The system model presented in this paper can be a valuable reference for further similar development to build an electronic business to achieve the low cost, high efficiency, high security message exchange for digital firms at this internet era.
The Relaxant Effect of Propofol on Guinea Pig Tracheal Muscle Is Independent of Airway Epithelial Function and beta-Adrenoceptor Activity (1999)

Airway epithelium and vascular endothelium modulate the tension of the underlying smooth muscle by releasing relaxing factors such as prostanoids and nitric oxide (NO).We investigated whether the relaxant effect of propofol on airway smooth muscle is dependent on airway epithelial function. Tracheal spirals of female guinea pigs were mounted in water-jacketed organ baths filled with Krebs-bicarbonate buffer aerated with 95% O2 and 5% CO2 at 37[degree sign]C. Changes in isometric tension of the specimens were measured with a force-displacement transducer and recorded with a polygraph. Propofol (10-4 to 10-3 M) inhibited carbachol (CCh)-, histamine (HA)-, or endothelin-1-induced contractions of the muscles in a dose-dependent manner. Neither mechanical removal of the epithelial layer, chemical inhibition of epithelial synthesis of prostanoids, nor NO affected the relaxant effect of propofol on CCh- or HA-induced tracheal contraction. Furthermore, the blockade of beta-adrenoceptors did not change the relaxant effect of propofol. These results indicate that the relaxant effect of propofol on the airway smooth muscle is independent of the epithelial function or beta-adrenoceptor activity. Propofol is an excellent anesthetic for patients with hyperreactive airways in which the epithelial layer is damaged. Implications: Airway epithelium, as well as vascular endothelium, plays an important role in modulating the baseline tone and reactivity of underlying smooth muscle. We investigated, in vitro, whether the relaxant effect of propofol on airway smooth muscle is dependent on airway epithelial function. We suggest that propofol relaxes airway smooth muscle independently of the epithelial function. (Anesth Analg 1999;89:191-6)
Advantageous environment of micro-patterned, high-density complementary metal–oxide–semiconductor electrode array for spiral ganglion neurons cultured in vitro (2018)

This study investigated micro-patterned, high-density complementary metal-oxide-semiconductor (CMOS) electrode array to be used as biologically permissive environment for organization, guidance and electrical stimulation of spiral ganglion neurons (SGN). SGNs extracted and isolated from cochleae of P5-P7 rat pups and adult guinea pigs were cultured 1, 4 and 7 days in vitro on glass coverslips (control) and CMOS electrode array. The cultures were analyzed visually and immunohistochemically for SGN presence, outgrowth, neurite alignment, neurite length, neurite asymmetry as well as the contact of a neuronal soma and neurites with the micro-electrodes. Our findings indicate that topographical environment of CMOS chip with micro-patterned pillars enhanced growth, survival, morphology, neural orientation and alignment of SGNs in vitro compared to control. Smaller spacing (0.8-1.6 µm) between protruding pillars on CMOS led SGNs to develop structured and guided neurites oriented along three topographical axes separated by 60°. We found morphological basis for positioning of the micro-electrodes on the chip that was appropriate for direct contact of SGNs with them. This configuration allowed CMOS electrode array to electrically stimulate the SGN whose responses were observed with live Fluo 4 calcium imaging.
Flow Boiling Critical Heat Flux in Reduced Gravity (2004)

This study provides systematic method for reducing power consumption in reduced gravity systems by adopting minimum velocity required to provide adequate CHF and preclude detrimental effects of reduced gravity . This study proves it is possible to use existing 1 ge flow boiling and CHF correlations and models to design reduced gravity systems provided minimum velocity criteria are met
Synthesis, Photophysics, and Reverse Saturable Absorption of trans-Bis-cyclometalated Iridium(III) Complexes (C^N^C)Ir(R-tpy)+ (tpy = 2,2′:6′,2″-Terpyridine) with Broadband Excited-State Absorption (2020)

Extending the bandwidth of triplet excited-state absorption in transition-metal complexes is appealing for developing broadband reverse saturable absorbers. Targeting this goal, five bis-terdentate iridium(III) complexes (<b>Ir1</b>-<b>Ir5</b>) bearing <i>trans</i>-bis-cyclometalating (C^N^C) and 4'-R-2,2':6',2″-terpyridine (4'-R-tpy) ligands were synthesized. The effects of the structural variation in cyclometalating ligands and substituents at the tpy ligand on the photophysics of these complexes have been systematically explored using spectroscopic methods (i.e., UV-vis absorption, emission, and transient absorption spectroscopy) and time-dependent density functional theory (TDDFT) calculations. All complexes exhibited intensely structured <sup>1</sup>π,π* absorption bands at <400 nm and broad charge transfer (<sup>1</sup>CT)/<sup>1</sup>π,π* transitions at 400-600 nm. Ligand structural variations exerted a very small effect on the energies of the <sup>1</sup>CT/<sup>1</sup>π,π* transitions; however, they had a significant effect on the molar extinction coefficients of these absorption bands. All complexes emitted featureless deep red phosphorescence in solutions at room temperature and gave broad-band and strong triplet excited-state absorption ranging from the visible to the near-infrared (NIR) spectral regions, with both originating from the <sup>3</sup>π,π*/<sup>3</sup>CT states. Although alteration of the ligand structures influenced the emission energies slightly, these changes significantly affected the emission lifetimes and quantum yields, transient absorption spectral features, and the triplet excited-state quantum yields of the complexes. Except for <b>Ir3</b>, the other four complexes all manifested reverse saturable absorption (RSA) upon nanosecond laser pulse excitation at 532 nm, with the decreasing trend of RSA following <b>Ir2</b> ≈ <b>Ir4</b> > <b>Ir1</b> > <b>Ir5</b> > <b>Ir3</b>. The RSA trend corresponded well with the strength of the excited-state and ground-state absorption differences (ΔOD) at 532 nm for these complexes.
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase (2000)

The BCR/ABL oncogene results from a balanced translocation between chromosomes 9 and 22 and is found in patients with chronic myeloid leukemia (CML) and in some patients with acute B-lymphoid leukemia. The Bcr/Abl fusion protein is a constitutively active tyrosine kinase that stimulates several intracellular signaling pathways, including activation of Ras through direct binding of the SH2-containing adapter protein Grb2 to Bcr tyrosine 177. A tyrosine-to-phenylalanine mutation (Y177F) at this site blocks the co-association of Bcr/Abl and Grb2 in vivo and impairs focus formation by Bcr/Abl in fibroblasts. However, the Bcr/Abl Y177F mutant can transform hematopoietic cell lines and primary bone marrow cells in vitro, so the importance of the Bcr/Abl-Grb2 interaction to myeloid and lymphoid leukemogenesis in vivo is unclear. We have recently demonstrated the efficient induction of CML-like myeloproliferative disease by BCR/ABL in a murine bone marrow transduction/transplantation model system. The Y177F mutation greatly attenuates the myeloproliferative disease induced by BCR/ABL, with mice developing B- and T-lymphoid leukemias of longer latency. In addition, the v-abl oncogene of Abelson murine leukemia virus, whose protein product lacks interaction with Grb2, is completely defective for the induction of CML-like disease. These results suggest that direct binding of Grb2 is required for the efficient induction of CML-like myeloproliferative disease by oncogenic Abl proteins. (Blood. 2000;96:664-670)
Cultural, Economic and Societal Impacts on Users’ Behaviour and Mobile Broadband Adoption Trends (2017)

The diverse range of Internet enabled devices both mobile and fixed has not only impacted the global economy but the very fabric of human communications and lifestyles. The ease of access and lowered cost has enabled hitherto diametrically opposed people to interact and influence each other globally. The consequence of which is the dire need to address the way culture affects interaction with information systems across the world. The many facets of which encompasses human behaviour, socio-economic and cultural factors including lifestyles and the way of interaction with the information system. The study group involved participants from Bangladesh and the United Kingdom to ascertain the users’ behavioural patterns and mobile broadband technology diffusion trends.
Optical Power Propagation In Chalcogenide Glass Fibers At 10.6 µm (1988)

This paper describes the preparation and characterization of chalcogenide fibers for applications such as imaging and remote optical powering. The fibers were drawn from rod preforms and clad with a UV-cured urethane acrylate coating. The polymer clad fibers were 250 gm in diameter. Extended lengths up to 0.5 km of fiber were achieved that exhibited excellent strength and flexibility.
Release and Diffusion Rate of Helium in Neutron-Irradiated SiC (2004)

Helium release measurements and diffusion coefficient calculations of helium in a neutron-irradiated α-SiC have been carried out in the temperature range of 750 1,260°C. The powder was obtained from SiC ceramics containing B4C, of which 10B concentration was 4.2×1016atom/mg. Neutron irradiation was conducted up to a fluence of 2.8×1024n/m2 (E>0.1 MeV) ~300°C. The diffusion coefficients were calculated for the temperature region of 750-1,060°C with time range of 0-10 min. The diffusion coefficient of helium for SiC containing B4C was D (cm2/s)=1.38×1010exp[—0.91±0.07 (eV/atom)/kT]. Dissociative and interstitial diffusion mechanisms were supposed. Diffusion coefficients were reduced above ~1,160°C probably due to accelerated migration of vacancies.
Qualitative amniotic fluid volume versus amniocentesis in predicting infection in preterm premature rupture of the membranes. (1986)

Qualitative amniotic fluid volume assessment and amniocentesis were performed on admission in 54 patients who presented with premature rupture of the membranes and no clinical signs of infection or labor. Comparison of these two methods in predicting infection outcome--as reflected by the development of clinical amnionitis and/or neonatal sepsis--suggests them to have the same efficacy in predicting infection outcome in patients with premature rupture of the membranes. Qualitative amniotic fluid volume was found to have sensitivity 50%, specificity 92.8%, positive predictive value 66.6%, and negative predictive value 86.6%; amniocentesis was found to have sensitivity 58.3%, specificity 88%, positive predictive value 58.3%, and negative predictive value 88%. The use of ultrasonically estimated amniotic fluid volume could replace or be used in addition to amniocentesis in identifying patients with ruptured membranes at particular risk for developing infection.
Second International Diagnostic Accuracy Study for the Serological Detection of West Nile Virus Infection (2013)

Background: In recent decades, sporadic cases and outbreaks in humans of West Nile virus (WNV) infection have increased. Serological diagnosis of WNV infection can be performed by enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA) neutralization test (NT) and by hemagglutination-inhibition assay. The aim of this study is to collect updated information regarding the performance accuracy of WNV serological diagnostics.
A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo (2015)

Alzheimer's disease (AD) and familial Danish dementia (FDD) are degenerative neurological diseases characterized by amyloid pathology. Normal human sera contain IgG antibodies that specifically bind diverse preamyloid and amyloid proteins and have shown therapeutic potential in vitro and in vivo. We cloned one of these antibodies, 3H3, from memory B cells of a healthy individual using a hybridoma method. 3H3 is an affinity-matured IgG that binds a pan-amyloid epitope, recognizing both Aβ and λ Ig light chain (LC) amyloids, which are associated with AD and primary amyloidosis, respectively. The pan-amyloid-binding properties of 3H3 were demonstrated using ELISA, immunohistochemical studies, and competition binding assays. Functional studies showed that 3H3 inhibits both Aβ and LC amyloid formation in vitro and abrogates disruption of hippocampal synaptic plasticity by AD-patient-derived soluble Aβ in vivo. A 3H3 single-chain variable fragment (scFv) retained the binding specificity of the 3H3 IgG and, when expressed in the brains of transgenic mice using an adeno-associated virus (AAV) vector, decreased parenchymal Aβ amyloid deposition in TgCRND8 mice and ADan (Danish Amyloid) cerebral amyloid angiopathy in the mouse model of FDD. These data indicate that naturally occurring human IgGs can recognize a conformational, amyloid-specific epitope and have potent anti-amyloid activities, providing a rationale to test their potential as antibody therapeutics for diverse neurological and other amyloid diseases.
Efficient Interactive Annotation of Segmentation Datasets with\n Polygon-RNN++ (2018)

Manually labeling datasets with object masks is extremely time consuming. In\nthis work, we follow the idea of Polygon-RNN to produce polygonal annotations\nof objects interactively using humans-in-the-loop. We introduce several\nimportant improvements to the model: 1) we design a new CNN encoder\narchitecture, 2) show how to effectively train the model with Reinforcement\nLearning, and 3) significantly increase the output resolution using a Graph\nNeural Network, allowing the model to accurately annotate high-resolution\nobjects in images. Extensive evaluation on the Cityscapes dataset shows that\nour model, which we refer to as Polygon-RNN++, significantly outperforms the\noriginal model in both automatic (10% absolute and 16% relative improvement in\nmean IoU) and interactive modes (requiring 50% fewer clicks by annotators). We\nfurther analyze the cross-domain scenario in which our model is trained on one\ndataset, and used out of the box on datasets from varying domains. The results\nshow that Polygon-RNN++ exhibits powerful generalization capabilities,\nachieving significant improvements over existing pixel-wise methods. Using\nsimple online fine-tuning we further achieve a high reduction in annotation\ntime for new datasets, moving a step closer towards an interactive annotation\ntool to be used in practice.\n
QoS Prediction for High Speed Packet Access Networks (2008)

By employing Bayesian neural network, a new QoS prediction algorithm for high speed packet access network has been developed. Network performances are evaluated based on a well developed call admission control scheme, namely the tri-threshold bandwidth reservation scheme. The algorithm helps to improve the resource management, thus saving the cost and bandwidth.
Dynamic Bandwidth Allocation Algorithm for Orthogonal Frequency Division Multiplexing Access-passive Optical Network (2011)

An architecture of next generation access network namely orthogonal frequency division multiplexing passive optical network was presented,which has high spectrum efficiency,fine bandwidth granularity and low cost.A novel efficient dynamic bandwidth allocation algorithm based on orthogonal frequency division multiplexing passive optical network namely fixed cyclic polling in pipeline dynamic bandwidth allocation algorithm was investigated.To meet the quality of service requirements under multi-services access scenario,two level bandwidth allocation mechanisms,bandwidth pre-request for expedited forward service and the smallest bandwidth request allocated the first principle for assured forwarding and the best effort services were applied in this algorithm.A simulation was conducted to study the performance of fixed cyclic polling in pipeline dynamic bandwidth allocation algorithm in orthogonal frequency division multiplexing passive optical network.The results show that the proposed algorithm supports expedited forwarding services with low packet average delay and low jitter,balances priority and fairness between assured forwarding services and best effort services,and achieves bandwidth allocation fairness among different optical network units in the same priority.Compared with the traditional dynamic bandwidth allocation algorithms,fixed cyclic polling in pipeline algorithm meets the quality of service requirements excellently,and adapts orthogonal frequency division multiplexing passive optical network better with higher bandwidth efficiency and lower algorithm complexity.
SAMU: Design and implementation of selectivity-aware MU-MIMO for wideband WiFi (2015)

In anticipation of the increasing demand of wireless traffic, WiFi standardization efforts have recently focused on two key technologies for capacity improvement: multi-user MIMO and wider bandwidth. However, users experience heterogeneous channel orthogonality characteristics across sub-carriers in the same channel bandwidth, which prevents ideal multi-user gain. Moreover, frequency selectivity increases as bandwidth scales and correspondingly severely deteriorates multi-user MIMO performance. In this work, we consider the frequency selectivity of current and emerging WiFi channel bandwidths to optimize multi-user MIMO by dividing the occupied channel bandwidth into equally-sized sub-channels according to the level of frequency selectivity. In our selectivity-aware multi-user MIMO design, SAMU, each sub-channel is allocated according to the largest bandwidth that can be considered frequency-flat, and an optimal subset of users is chosen to serve in each sub-channel according to spatial orthogonality, achieving a significant performance improvement for all users in the network. Additionally, we propose a selectivity-aware very high throughput (SA-VHT) mode, which is based on and an extension to the existing IEEE 802.11ac standard. Over emulated and real indoor channels, even with minimal mobility, SAMU achieves as much as 80 percent throughput improvement compared to existing multi-user MIMO schemes, which could serve as a lower bound as bandwidth scales.
Mechanistic study of decomposition of Nitro Methane encapsulated in CNT Nanocontainer via Reactive Molecular Dynamics (2016)

Nitro Methane (NM) is the simplest type of nitro compound in high explosive energetic material (HE), which finds explosion-related applications. Decomposition mechanism of the confined NM inside the isolated capped carbon nanotube (CNT) container was studied through reactive molecular dynamics simulation. Initial densities of NM and thermal shock conditions were expected to give a major impact on the decomposition pathway of NM&amp;amp;#8211;CNT container. The five systems at different densities (i.e. 1.137, 1.2, 1.3, 1.5, and 1.7 g/cc) with four initial shock temperatures (i.e. 2500, 3000, 3500, and 4000 K) were considered in this study. Each system was run with NVE MD simulations after introducing fast heat-up procedure with NVT MD simulation. Cascading release of the potential energy from decomposed NM resulted in the elevation of the reaction temperature, which stimulated the accelerated decomposition reaction, while reaction mechanism was traced by generated intermediates and products. Finally, the NM-CNT container was burst at the final stage of the reaction. The explosive decomposition of confined NM, which has never been reported, was first introduced in this study.
Lipids from Oxidized Low-Density Lipoprotein Modulate Human Trophoblast Invasion: Involvement of Nuclear Liver X Receptors (2004)

Human embryonic implantation involves major invasion of the uterine wall and remodeling of the uterine arteries by extravillous cytotrophoblast cells (EVCT). Abnormalities in these early steps of placental development lead to poor placentation and fetal growth defects and are frequently associated with preeclampsia, a major complication of human pregnancy. We recently showed that oxidized low-density lipoproteins (oxLDLs) are present in situ in EVCT and inhibit cell invasion in a concentration-dependent manner. The aim of the present study was to better understand the mechanisms by which oxLDL modulate trophoblast invasion. We therefore investigated the presence of oxLDL receptors in our cell culture model of human invasive primary EVCT. We found using immunocytochemistry and immunoblotting that the lectin-like oxLDL receptor-1 was the scavenger receptor mainly expressed in EVCT and was probably involved in oxLDL uptake. We next examined the effect of low-density lipoprotein oxidative state on trophoblast invasion in vitro using EVCT cultured on Matrigel-coated Transwell. We demonstrated that only oxLDL containing a high proportion of oxysterols and phosphatidylcholine hydroperoxide derivatives that provide ligands for liver X receptor (LXR) and peroxisomal proliferator-activated receptor gamma (PPARgamma), respectively, reduced trophoblast invasion. We next investigated the presence and the role of these nuclear receptors and found that in addition to PPARgamma, human invasive trophoblasts express LXRbeta, and activation of these nuclear receptors by specific synthetic or natural ligands inhibited trophoblast invasion. Finally, using a PPARgamma antagonist, we suggest that LXRbeta, rather than PPARgamma, is involved in oxLDL-mediated inhibition of human trophoblast invasion in vitro.