gebhart/patrepeval huggingface dataset:
Enhancing Accuracy Performance of Bluetooth Positioning (2007)

Huge popularity of mobile devices and Internet open new application field of wireless positioning and navigation systems, and this integration also brings new research issues. Currently the positioning and navigation systems are mostly based on satellite positioning systems, such as GPS. One serious drawback of these satellite based positioning and navigation systems is that they can only operate in outdoor environment. There are several approaches for wireless positioning, e.g. cell ID, DOA (directions of arrivals) or signal strength measurements, but these approaches can not meet requirements of wireless positioning, including latency, availability and accuracy. In this paper, we propose a new approach for Bluetooth positioning, which is based on the time offset acquisition of signals propagating over radio channel, and the forward-backward ranging. Through simulations and experiments, it shows that the new Bluetooth ranging approach could give high ranging accuracy with modest modifications of current Bluetooth technology.
Probiotic characteristics and zearalenone-removal ability of a Bacillus licheniformis strain (2018)

Zearalenone (ZEN) is a mycotoxin produced by Fusarium species, which is one of the main animal feed contaminants causing reproductive disorders in livestock. The aim of this study was to evaluate the probiotic characteristics and ZEN removal ability of a Bacillus licheniformis strain CK1. The probiotic properties, including acidic tolerance, bile salt tolerance, adherence capability, and anti-pathogenic activities of CK1 were evaluated. CK1 survived after incubation at pH 2.0 or 3.0 for 3 h, grew well in LB broth containing 0.3% oxgall, possessed adherence capability to Caco-2 cells, and inhibited the growth of Escherichia coli O157:H7 and Listeria monocytogenes. The ZEN removal ability of CK1 was compared with a mineral mycotoxin-adsorbing agent, hydrated sodium calcium aluminosilicate (HSCAS), and a well-characterized biological mycotoxin-adsorbing agent, Lactobacillus rhamnosus GG (LGG). At 37°C in phosphate-buffered saline (PBS, pH 7.0) containing 5 μg mL-1 of ZEN, the ZEN removal percentage of CK1 was 73.0%, which was significantly higher than that of HSCAS and LGG (45.9% and 48.4%, respectively). In the pH range of 2.5-8.0, CK1 removed up to 65% of ZEN. At temperatures between 4 and 42°C, CK1 removed more than 75% of ZEN. In the adsorption stability analysis, the amounts of ZEN removed by CK1 was over 30% even after five consecutive rounds of washing procedures. These findings demonstrated that CK1 displayed probiotic characteristics and removed ZEN effectively. Therefore, CK1 has a great potential for the development of feed additive to remove ZEN.
Antibody response of Schistosoma mansoni-infected human subjects to the recombinant P28 glutathione-S-transferase and to synthetic peptides (1990)

The 28-kilodalton antigen of Schistosoma mansoni has been previously described as having importance as the basis for a potential vaccine. The P28 recombinant molecule and three peptides derived from its primary sequence, namely the 24-43, 115-131, and 140-153 peptides, have been tested to evaluate the humoral responses of Kenyan school children previously classified as susceptible or resistant to reinfection after chemotherapy. We report here that the P28 molecule and two of the peptides studied (peptides 115-131 and 140-153) can be used for detecting specific immunoglobulin G (IgG), IgE, and IgA antibodies. Moreover, the IgG4 response of the susceptible population was significantly greater than that of the resistant group, whereas no differences between the two populations were noticed in total IgG anti-P28 antibodies. This suggested that IgG4 could play a role in the lack of immunity of susceptible patients. A strong IgG3 response restricted to the 140-153 peptide was observed but did not discriminate between the resistant and susceptible populations. In contrast, a marked increase in the IgA response to the 140-153 peptide epitope(s) in sera of the resistant population was noticed. Taken together, these results suggest that the P28 antigen and two of the three peptides selected could give predictive information about the development of the disease or the efficiency of vaccination with P28 as the immunogen.
Wearable Pulse Wave Monitoring System Based on MEMS Sensors (2018)

Pulse wave monitoring is critical for the evaluation of human health. In this paper, a wearable multi-sensor pulse wave monitoring system is proposed and demonstrated. The monitoring system consists of a measuring unit and an analog circuit processing unit. The main part of the measuring unit is a flexible printed circuit board (PCB) with a thickness of 0.15 mm, which includes three micro-electromechanical system (MEMS) pressure sensors softly packaged by polydimethylsiloxane (PDMS), a blood oxygen detector and a MEMS three-axis accelerometer. The MEMS pressure sensors，the blood oxygen detector and the accelerometer are fixed on the expected locations of the flexible PCB. The analog circuit processing unit includes a power supply module, a filter and an amplifier. The pulse waves of two volunteers are detected by the monitoring system in this study. The output signals of the analog circuit processing module are processed and analyzed. In the preliminary test, the time delay of the three pressure pulse waves has been detected and the calculated pulse wave velocities (PWVs) are 12.50 and 11.36 m/s, respectively. The <i>K</i> value, related to the area of the pulse wave, can be obtained. Both the PWV and <i>K</i> value meet the health parameter standards.
Genipin Protects Engineered Cartilage Against IL-1alpha Induced Degradation (2008)

Tissue-engineering has great potential for treating cartilage pathologies such as osteoarthritis by replacing degraded tissue with newly developed engineered tissue. However proinflammatory cytokines such as interleukin-1α (IL-1α) are a confounding issue as they are often present in high concentrations as part of the chronic pathology or as a result of the surgical intervention itself(1). The catabolic effects of these mediators may be especially pronounced in engineered tissues whose cells are not yet fully embedded in the potentially chondroprotective enclosure of a cartilaginous extracellular matrix(2). One method to protecting initially fragile constructs from degradation may be through the use of non-toxic cross-linking agents. Genipin is a naturally occurring crosslinking agent that reacts with amino acids or amine groups and leads to the formation of stable crosslinked products that are identifiable by a dark blue pigment (Figure 1). Cartilage cross-linked with genipin has been shown to be more resistant to collagenase digestion(3) and to injection of chondroitinase-ABC(4). In this study, we examined whether engineered constructs pre-treated with genipin would better resist IL-1α induced catabolic degradation.
Can We Improve Cardiovascular Disease for Women Using Data Under Our Noses? (2020)

Cardiovascular disease (CVD) remains the leading cause of death among women, resulting in 418,665 deaths in 2016, and accounts for 1 in every 4 female deaths in the United States.(1) There are important sex and gender differences in CVD between women and men that contribute to diagnostic, prognostic and treatment uncertainty, resulting in suboptimal CVD care in women. Understanding and addressing these sex and gender differences is an opportunity to improve human health for both women and men. Notably, 86% of US women have at least one pregnancy, and prior work consistently identifies the 1 in 5 pregnancies with adverse pregnancy outcomes (APOs), such as gestational hypertensive disorders including pre-eclampsia, to elevate risk for future CVD in women.(2) In short, a risk predictor readily available in the vast majority of women – literally under our collective nose - might be harnessed for relevant sex-specific atherosclerotic CVD (ASCVD) risk information to address the preventive, diagnostic and treatment gaps that adversely impact women.
A Semicrystalline Poly(azobenzene) Exhibiting Room Temperature Light-Induced Melting, Crystallization, and Alignment (2022)

Photomechanical materials powered by light-induced changes in crystalline lattices offer promise for improved performance due to the high degree of coordination between the shape changes of individual molecules. While photoswitchable semicrystalline polymers present an attractive combination of molecular ordering and material processability, systems developed to date typically show high glass transition (Tg) and melting (Tm) temperatures, limiting their ability to undergo rapid and complete photoswitching under ambient conditions. Here, we prepare a semicrystalline poly(azobenzene) containing an ethylene glycol chain extender, denoted as P(EG-azo). Because of its backbone flexibility, P(EG-azo) shows values of Tg (−20 °C) and Tm (74 °C) that are substantially lower than the previously reported analogous polymer prepared with an alkyl chain extender. This decrease in Tg and Tm translates to rapid and thorough photomelting and photocrystallization at room temperature with high reversibility. Reversible photoactuation of P(EG-azo) fibers is demonstrated, with bending deformations corresponding to an estimated specific work of 0.6 kJ m–3, 30 times larger than for previous semicrystalline poly(azobenzene) photoactuators at room temperature. In addition, photoalignment of P(EG-azo) through selective melting and templated crystallization provides a convenient and energy-efficient route to rewritable orientation with an order parameter of up to S = 0.35.
Epistasis and the genetics of human diseases (2005)

Epistasis or modifier genes, that is, gene-gene interactions of non-allelic partners, play a major role in susceptibility to common human diseases. This old genetic concept has experienced a major renaissance recently. Interestingly, epistatic genes can make the disease less severe, or make it more severe. Hence, most diseases are of different intensities in different individuals and in different ethnicities. This phenomenon affects sickle-cell anemia carriers and other hemoglobinopathies, systemic lupus erythematosus, cystic fibrosis, complex autoimmune diseases, venous thromboembolism, and many others. It is likely, and fortunate, than 20 years form now, patients entering a medical facility will be subjected to a genomic scanning, including pathogenic genes as well as epistatic genes.
Pedestrian smartphone-based indoor navigation using ultra portable sensory equipment (2010)

Smartphones are largely benefiting from the ever increasing rate of integration of mobile IT components. Their increasing processing power and the fact that they are fitted with GNSS-receivers make them ideal for hand-held pedestrian navigation solutions. This document proposes a pedestrian indoor navigation system based on a custom inertial navigation system and the N900 smartphone made by Nokia. The system does not depend on a particular indoor navigation system, but attempts to support its inertial navigation system by selecting the optimal set of auxiliary information from available infrastructure such as WLAN and bluetooth. Analysis focuses on the development of the inertial navigation hardware, the definition of an optimal set of support information and the development of an efficient sensor fusion algorithm.
Towards machine learning prediction of deep brain stimulation (DBS) intra-operative efficacy maps (2019)

Deep brain stimulation (DBS) has the potential to improve the quality of life of people with a variety of neurological diseases. A key challenge in DBS is in the placement of a stimulation electrode in the anatomical location that maximizes efficacy and minimizes side effects. Pre-operative localization of the optimal stimulation zone can reduce surgical times and morbidity. Current methods of producing efficacy probability maps follow an anatomical guidance on magnetic resonance imaging (MRI) to identify the areas with the highest efficacy in a population. In this work, we propose to revisit this problem as a classification problem, where each voxel in the MRI is a sample informed by the surrounding anatomy. We use a patch-based convolutional neural network to classify a stimulation coordinate as having a positive reduction in symptoms during surgery. We use a cohort of 187 patients with a total of 2,869 stimulation coordinates, upon which 3D patches were extracted and associated with an efficacy score. We compare our results with a registration-based method of surgical planning. We show an improvement in the classification of intraoperative stimulation coordinates as a positive response in reduction of symptoms with AUC of 0.670 compared to a baseline registration-based approach, which achieves an AUC of 0.627 (p < 0.01). Although additional validation is needed, the proposed classification framework and deep learning method appear well-suited for improving pre-surgical planning and personalize treatment strategies.
Relating 18F-FDG image signal-to-noise ratio to time-of-flight noise-equivalent count rate in total-body PET using the uEXPLORER scanner (2022)

<i>Objective.</i>This work assessed the relationship between image signal-to-noise ratio (SNR) and total-body noise-equivalent count rate (NECR)-for both non-time-of-flight (TOF) NECR and TOF-NECR-in a long uniform water cylinder and 14 healthy human subjects using the uEXPLORER total-body PET/CT scanner.<i>Approach.</i>A TOF-NEC expression was modified for list-mode PET data, and both the non-TOF NECR and TOF-NECR were compared using datasets from a long uniform water cylinder and 14 human subjects scanned up to 12 h after radiotracer injection.<i>Main results.</i>The TOF-NECR for the uniform water cylinder was found to be linearly proportional to the TOF-reconstructed image SNR<sup>2</sup>in the range of radioactivity concentrations studied, but not for non-TOF NECR as indicated by the reduced<i>R</i><sup>2</sup>value. The results suggest that the use of TOF-NECR to estimate the count rate performance of TOF-enabled PET systems may be more appropriate for predicting the SNR of TOF-reconstructed images.<i>Significance.</i>Image quality in PET is commonly characterized by image SNR and, correspondingly, the NECR. While the use of NECR for predicting image quality in conventional PET systems is well-studied, the relationship between SNR and NECR has not been examined in detail in long axial field-of-view total-body PET systems, especially for human subjects. Furthermore, the current NEMA NU 2-2018 standard does not account for count rate performance gains due to TOF in the NECR evaluation. The relationship between image SNR and total-body NECR in long axial FOV PET was assessed for the first time using the uEXPLORER total-body PET/CT scanner.
Phase 1 study of PSCA-targeted chimeric antigen receptor (CAR) T cell therapy for metastatic castration-resistant prostate cancer (mCRPC). (2022)

91 Background: Chimeric antigen receptor (CAR)-engineered T cell therapies are being pursued for the treatment of mCRPC. Prostate Stem Cell Antigen (PSCA) is highly expressed on the surface membrane in mCRPC and with limited expression on normal tissues. We undertook a phase 1, first-in-human study of a PSCA-targeted 4-1BB-co-stimulated CAR T cell therapy in mCRPC. Methods: CAR T cells were manufactured at City of Hope’s cGMP facility. The trial followed the Target equivalence range design with an equivalence range of.20-.35 and too toxic level of 0.51 following participants in cohorts of 3. The plan was to begin at a dose of 100 million (M) without lymphodepletion (LD) chemotherapy consisting of fludarabine and cyclophosphamide, then add LD to 100M prior to dose escalation to maximum 600M. Patients (pts) were required to have disease progression after at least 1 androgen receptor targeted therapy but there was no limit on prior chemotherapy or other treatments. Primary objective is to define the dose limiting toxicity (DLT) and recommended phase 2 dose as well as to describe preliminary bioactivity and efficacy. Correlative studies include MRI for target bone lesion response, CAR T cell persistence, circulating tumor cells, and serum cytokines. Results: 12 pts have been treated to date, median age 68 (42-72). Three pts were treated at the 100M dose with no DLTs. In the 100M plus LD dose level there 2 pts experienced DLT of grade 3 cystitis non-infective and fatigue. The protocol was amended to reduce the LD dose to 300 mg/m2 cyclophosphamide D1-3 and intensify monitoring with early intervention for cystitis. No DLT occurred in 3 pts treated in the modified LD 100M cohort. Cytokine release syndrome (CRS), DLTs and best response by RECIST are presented by dose level in the table. PSA declines (one &gt;90%) were seen as well as radiographic improvement, though RECIST response was limited to stable disease (SD) by concurrent bone metastases. Correlative studies indicated bioactivity of PSCA-CAR T cells. Conclusions: PSCA-CAR T cell therapy is feasible in pts with mCRPC with DLT of cystitis, and shows preliminary anti-tumor effect at a dose of 100M plus LD. Dose escalation to 300M may proceed. Clinical trial information: NCT03873805. [Table: see text]
Characterization of two conformational epitopes of the Chlamydia trachomatis serovar L2 DnaK immunogen (1996)

Chlamydia trachomatis DnaK is an important immunogen in chlamydial infections. DnaK is composed of a conserved N-terminal ATP-binding domain and a variable C-terminal peptide-binding domain. To locate the immunogenic part of C. trachomatis Dnak, we generated monoclonal antibodies (MAbs) against this protein. By use of recombinant DNA techniques, we located the epitopes for two MAbs in the C-terminal variable part. Although the antibodies reacted in an immunoblot assay, it was not possible to map the epitopes completely by use of 16-mer synthetic peptides displaced by one amino acid corresponding to the C-terminal part of C. trachomatis DnaK. To determine the limits of the epitopes, C. trachomatis DnaK and glutatione S-transferase fusion proteins were constructed and affinity purified. The purified DnaK fusion proteins were used for a fluid-phase inhibition enzyme-linked immunosorbent assay with the two antibodies. The epitopes were found not to overlap. To obtain DnaK fragments recognized by the antibodies with the same affinity as native C. trachomatis DnaK, it was necessary to express, respectively, regions of 127 and 77 amino acids. The MAbs described in this study thus recognized conformational epitopes of C. trachomatis DnaK.
Number of implants placed for complete‐arch fixed prostheses: A systematic review and meta‐analysis (2018)

OBJECTIVES The main purpose of this systematic review was to evaluate outcomes related to the number of implants utilized to support complete-arch fixed prostheses, both for the maxilla and the mandible. MATERIALS AND METHODS This review followed the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A focused question using the PICO format was developed, questioning whether In patients with an implant supported fixed complete dental prosthesis, do implant and prosthetic survival outcomes differ between or compared to than supporting implants?. A comprehensive search of the literature was formulated and performed electronically and by hand search. Two independent reviewers selected the papers and tabulated results. Primary outcomes analyzed were implant and prosthesis survival. Implant distribution, loading, and type of retention were observed as secondary outcomes, as they relate to the number of implants. A meta-analysis was performed to compare results for studies by number of implants. RESULTS The search strategy identified 1,579 abstracts for initial review. Based on evaluation of the abstracts, 359 articles were identified for full-text evaluation. From these, 93 were selected and included in this review, being nine RCTs, 42 prospective and 42 retrospective. Of the 93 selected studies, 28 reported number of implants for the maxilla, 46 for the mandible, and 19 for both maxilla and mandible. The most reported number of implants for the fewer than group is 4 for the maxilla, and 3 and 4 for the mandible, whereas for the five or more implants group, the most reported number of implants was 6 for the maxilla and 5 for the mandible. No significant differences in the primary outcomes analyzed were identified when than implants per arch were compared with or implants per arch (p > 0.05), in a follow-up time ranging from 1 to 15 years (median of 8 years). CONCLUSIONS Evidence from this systematic review and meta-analysis suggests that the use of than implants per arch, when compared to or implants per arch, to support a fixed prosthesis of the completely edentulous maxilla or mandible, present similar survival rates, with no statistical significant difference at a p < 0.05 and a confidence interval of 95%.
Sodium scandium diphosphate, NaScP2O7, isotypic with α-NaTi(III)P2O7 (2009)

Crystals of the title compound, NaScP(2)O(7), were grown by a flux method. The crystal structure is isotypic with those of α-NaTiP(2)O(7), NaYbP(2)O(7) and NaLuP(2)O(7), and is closely related to that of NaYP(2)O(7). The structural set-up consists of a three-dimensional framework of P(2)O(7) units that are corner-shared by ScO(6) octa-hedra, forming tunnels running parallel to [010]. The Na atoms are situated in the tunnels and are surrounded by nine O atoms in a distorted environment.
MPEG-7 standardization activities (2002)

MPEG-7 is the most recent standardization activity of the Moving Picture Experts Group (MPEG). MPEG-7 is still in its early stages where its scope, requirements, and evaluation procedures are being defined. It is expected to become an international standard in year 2001. The purpose of this paper is to serve as an introduction to MPEG-7, its scope and requirements, as well as the current state of its development process. MPEG-7 presents challenges to a number of technical communities including the image processing community.