gebhart/patrepeval huggingface dataset:
A switched–capacitor variable gain amplifier for CCD image sensor interface system (2002)

A new topology for a switched-capacitor variable gain amplifier (SC-VGA) is proposed and implemented in an analog-digital interface system for CCD image sensor. The SC-VGA exploits a positive feedback which leads to simpler circuit implementation, lower power consumption and reduced kT/C noise, compared to the conventional one. The gain, controlled by &amp;amp;bit digital signal, varies from 0 dB to 24 dB with O. 094-dB step. The measured gain of the SC-VGA shows monotonicity over the whole range of the gain (DNL &amp;lt; 1). Fabricated in 0.25-um CMOS process with MIM capacitors, the VGA occupies 0.25 mm 2 and dissipates 5 mW at 8 MHz with a supply voltage of 2.8 V.
[Effects of synergism during combined antioxidant action of phosphatidylcholine with natural and synthetic quinones]. (1994)

The combined action of ovarian phosphatidylcholine and phylloquinone (vitamin K1), menadione, artificial analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl-1,4-naphthoquinone (AK-40, AK-49) recommended as promising membrane protectors was studied. Synergic effects were detected in the antioxidant action of the quinones studied and phosphatidylcholine; AK-40 was the most effective in the presence of phosphatidylcholine. The synergic effect correlated with the concentrations of the antioxidants. Alterations in the synergism, which depended on phosphatidylcholine concentrations, were similar for all the inhibitors studied: the effect was proportionally increased with the elevation of phosphatidylcholine concentrations in the mixture up to 2.5 x 10(-3) M and then the synergic effect was unaltered during the further increase in phosphatidylcholine content.
High resolution navigated three‐dimensional T1‐weighted hepatobiliary MRI using gadoxetic acid optimized for 1.5 tesla (2012)

High-resolution navigated 3D-SPGR hepatobiliary imaging using gadoxetic acid and optimized scan parameters is technically feasible and can be clinically useful, even in patients with decreased hepatobiliary function.
The identification and satisfaction of consumer analysis‐driven information needs of marketers on the WWW (1998)

Investigates the information needs of marketers on the WWW for consumer analysis purposes, and examines how these can be met. Begins by briefly highlighting the attractiveness of the Web as a medium for communication. Next, summarizes the bases for consumer analysis and segmentation in the context of the traditional marketing communication media. Based on this framework, examines consumer analysis needs in the context of the WWW medium and proposes analysis variables relevant to this medium. Finally, discusses how the information needs for consumer analysis may be met from the different information sources available to a marketer, including the Web logfiles which are generated as a result of tracking the interactions of visitors accessing information from a company’s Web site.
Connective Tissue Growth Factor and Insulin-Like Growth Factor 2 Show Upregulation in Early Growth Plate Radiorecovery Response following Irradiation (2007)

IGF2 is upregulated in the PZ and CTGF is upregulated in both the PZ and HZ 1 week after irradiation, prior to the histomorphometric appearance of growth plate recovery in this immature animal radiation model, supporting their role in stimulating early return of the growth plate. By 2 weeks after irradiation, a number of growth factors and cytokines, including CTGF and Pthr1 in both zones, CXCL12 and its receptor in the PZ, and IL17b and bone morphogenetic protein 2 in the HZ, show upregulation, suggesting a possible later role in radiorecovery. The effects of irradiation on Pthr1, CTGF, IGF2 and CXCL12 in PZ and Pthr1, CTGF, IL17b and IGF1R in the HZ determined by microarray and real-time RT-PCR was highly correlated (r = 0.797, p < 0.05 in the PZ and r = 0.875, p < 0.01 in the HZ, respectively).
Bond Energy Relations in Alkali Phosphate Glasses (1982)

著者らは前報で既に報告したRPO3ガラスの溶解熱及び生成熱より全結合エネルギーを計算し, E(P=O)/E(P-O)=1.75及び2の場合につきP-O, P-OR, 及びP-O-結合へ割り振った. E(P=O)/E(P-O)=1.75の場合E(P-O) は90.3kcal/molであった. E(OR) の値は非架橋酸素-アルカリイオン間はクーロン力が支配的であり, しかもその値は, 構造的には異なっているがアルカリイオン対網目形成イオンの比の等しいR2Si2O5ガラスの値にほぼ等しい. また1.75<E (P=O)/E(P-O)<2, E(P-O)<E(P-O-) 及びE(Si-O)<E(Si-O-) なる結合エネルギーの関係をP-O及びSi-O間の3d-2pπ相互作用の立場から検討した.
Expression of heat shock protein 47 is increased in remnant kidney and correlates with disease progression (1998)

Glomerulosclerosis is characterized by accumulation of the mesangial extracellular matrix, including type I and V collagen. The processing for the collagens in the glomeruli may play a critical role for development of glomerulosclerosis. We examined the expression of heat shock protein 47 (HSP47), a collagen-binding molecular chaperone in the progressive glomerulosclerosis model. Subtotally nephrectomized rats, unlike sham-operated rats, developed focal and segmental glomerulosclerosis. Immunological staining demonstrated an increased expression of HSP47 which paralleled the expression of type I and IV collagen in the glomeruli of the nephrectomized rats as the glomerulosclerosis developed. The mRNA levels encoding type I and type IV collagen and HSP47 were increased 3.4 fold, 3.6 fold and 2.8 fold, respectively, at week 7 after nephrectomy. By in situ hybridization, the expression of HSP47 mRNA was determined to be localized to the glomeruli with segmental sclerosis. These results suggest that HSP47 may play a central role in the process of extracellular matrix accumulation during the development of glomerulosclerosis.
Nonlinear adaptive observer control for a riser slugging system in unstable wells (2008)

This paper presents a nonlinear observer-based control scheme to stabilize the downhole pressure and eliminate riser slugging. A simple empirical model is developed that describes the qualitative behavior of the downhole pressure in case of severe riser slugging. A new nonlinear adaptive observer is developed for state estimations with the new parameter adaptation law. The controller is designed by an integrator backstepping approach to stabilize the downhole pressure and achieve asymptotic tracking. The stabilization in the unstable region is demonstrated by the proposed control. For the design and implementation of the controller, no knowledge is assumed on the system parameters. It is shown that the proposed controller not only can guarantee asymptotic stability, but also transient performance.
The use of laser-based diagnostics for the rapid identification of blood borne viruses in human plasma samples (2021)

There is an ongoing need to rapidly detect viral infections and to screen for multiple viral infections. A laser-based approach can achieve sensitive, multiplex detection with minimal sample preparation and provide results within minutes. These properties along with the flexibility to add new agent detection by adjusting the detection programming make it a promising tool for clinical diagnosis. The potential for a laser-based approach has been previously demonstrated using pathogens spiked into human blood to clinically relevant levels. This study demonstrates this same ability to detect infections in clinical and laboratory spiked plasma samples. The ability to differentiate between plasma samples from infected and uninfected donors and determine the virus type using a laser-based diagnostic has not been previously demonstrated. Furthermore, this study is the first demonstration of the capability to differentiate viral infections in clinical plasma samples whereas previously published work used laboratory samples spiked with a virus or dealt with the detection of cancer in clinical plasma samples.
Biosynthesis of Xylobiose: A Strategic Way to Enrich the Value of Oil Palm Empty Fruit Bunch Fiber (2012)

Xylooligosaccharides are functional foods mainly produced during the hydrolysis of xylan by physical, chemical, or enzymatic methods. In this study, production of xylobiose was investigated using oil palm empty fruit bunch fiber (OPEFB) as a source material, by chemical and enzymatic methods. Xylanase-specific xylan hydrolysis followed by xylobiose production was observed. Among different xylanases, xylanase from FXY-1 released maximum xylobiose from pretreated OPEFB fiber, and this fungal strain was identified as Aspergillus terreus and subsequently deposited under the accession Number MTCC- 8661. The imperative role of lignin on xylooligosaccharides enzymatic synthesis was exemplified with the notice of xylobiose production only with delignified material. A maximum 262 mg of xylobiose was produced from 1.0 g of pretreated OPEFB fiber using FXY-1 xylanase (6,200 U/ml) at pH 6.0 and 45° C. At optimized environment, the yield of xylobiose was improved to 78.67 g/100 g (based on xylan in the pretreated OPEFB fiber).
Levels of Personality (2012)

A completely revised and updated edition of a much-acclaimed textbook providing a critical introduction to human personality for psychology students. Levels of Personality carefully avoids the traditional 'catalogue of theories' approach. Instead it relates theories to each other within a conceptual framework of different levels of behaviour, moving inwards and downwards from 'surface level' explanations. Analytic case studies then apply these levels of understanding to areas of special interest such as aggression and sexuality. The author adopts a deep analytical and critical approach and questions whether personality theory and research have really addressed important questions, or produced useful answers. This new edition incorporates two new chapters on personality disorders and on personality in the workplace, as well as improved pedagogical features including statistics boxes, assessment boxes, relevant websites and key references for each chapter.
OR27-03 Duration of Testosterone-Induced Acyclicity Influences Corpora Lutea Formation and Stromal Changes in a Transgender Mouse Model (2020)

Abstract The impact and reversibility of long-term gender-affirming testosterone (T) therapy on the reproductive axis of transgender men has not been well-established. Little is known about outcomes for transgender men interested in pausing T therapy to harvest oocytes or get pregnant. We previously established a translational mouse model to investigate T-induced acyclicity and ovarian perturbations. We hypothesized that the duration of T-induced acyclicity would impact the reversibility of cyclic and ovarian changes. To test this hypothesis, T-treated mice were assigned to two groups: (SHORT) 6 weeks of T therapy with immediate reversibility (1.5 mg T propionate pellet implant/removal, n = 5) and (LONG) 6 weeks of T therapy with a prolonged T washout phase (subcutaneous oil injections of T enanthate at 0.9 mg once weekly, n = 5). Control groups (placebo pellets n = 5, sesame oil vehicle injections n = 5) were run in parallel. Estrous cycles were monitored using daily vaginal cytology. Following cessation of T therapy, mice were sacrificed in diestrus after resumption of cyclicity for 4 cycles and ovarian histology examined. Data were analyzed in GraphPad Prism using Welch’s t-test or Mann-Whitney where appropriate. T therapy led to persistent diestrus within a week after T administration for all T-treated mice and none of the controls. The total duration of acyclicity was 6±1 weeks for the SHORT group, which was significantly shorter than the 11±2 weeks for the LONG group (mean ± s.d., p = 0.0079). With resumption of cyclicity, both the SHORT and LONG groups had a significantly lower percentage of days in estrus and higher percentage of days in metestrus as compared to their parallel age-matched controls. Ovarian histology for the SHORT group all showed regular corpora lutea and minimal stromal changes, however, 3/5 mice in the LONG group lacked corpora lutea and 4/5 revealed marked stromal cell hypertrophy. Similar stromal cell changes were not seen in control mice. In conclusion, the length of time of T-induced acyclicity appears to impact the development of stromal cell hypertrophy and formation of corpora lutea even after resumption of cyclicity with similar alterations to the estrous cycles. These findings may have clinical relevance for transgender men interested in fertility, based on duration of gender-affirming T therapy. Future work will aim to separate out the respective contributions of T exposure and acyclicity to the stromal phenotype.
Investigating the Feasibility of Stem Cell Enrichment Mediated by Immobilized Selectins (2007)

Hematopoietic stem cell therapy is used to treat both malignant and non-malignant diseases, and enrichment of the hematopoietic stem and progenitor cells (HSPCs) has the potential to reduce the likelihood of graft vs host disease or relapse, potentially fatal complications associated with the therapy. Current commercial HSPC isolation technologies rely solely on the CD34 surface marker, and while they have proven to be invaluable, they can be time-consuming with variable recoveries reported. We propose that selectin-mediated enrichment could prove to be a quick and effective method for recovering HSPCs from adult bone marrow (ABM) on the basis of differences in rolling velocities and independently of CD34 expression. Purified CD34+ ABM cells and the unselected CD34- ABM cells were perfused over immobilized P-, E-, and L-selectin-IgG at physiologic wall shear stresses, and rolling velocities and cell retention data were collected. CD34+ ABM cells generally exhibited lower rolling velocities and higher retention than the unselected CD34- ABM cells on all three selectins. For initial CD34+ ABM cell concentrations ranging from 1% to 5%, we predict an increase in purity ranging from 5.2% to 36.1%, depending on the selectin used. Additionally, selectin-mediated cell enrichment is not limited to subsets of cells with inherent differences in rolling velocities. CD34+ KG1a cells and CD34- HL60 cells exhibited nearly identical rolling velocities on immobilized P-selectin-IgG over the entire range of shear stresses studied. However, when anti-CD34 antibody was co-immobilized with the P-selectin-IgG, the rolling velocity of the CD34+ KG1a cells was significantly reduced, making selectin-mediated cell enrichment a feasible option. Optimal cell enrichment in immobilized selectin surfaces can be achieved within 10 min, much faster than most current commercially available systems.
Real‐Time Decision‐Support System for Freeway Management and Control (1994)

Traffic incidents are believed to cause about 60% of the congestion delay in the United States. Accordingly, a number of U.S. cities maintain Traffic Operations Centers (TOCs) for incident detection and response. However, TOC operators are currently loaded with many low‐level tasks in incident management. This process could potentially be automated by an intelligent system. This paper presents such a system called freeway real‐time expert‐system demonstration (FRED). FRED is designed to provide decision support for TOC operators in a simulated intelligent vehicle‐highway system operating environment. Based on traffic information from detectors on freeways and from an incident report database, FRED is able to detect and verify multiple incidents that occur on a freeway network, and give advice to TOC operators regarding incident response strategies. FRED is designed in such a way that new developments in the area of incident management can be easily incorporated into the existing structure.
Ferroelectric properties of wet-chemical patterned PbZr0.52Ti0.48O3 films (2005)

Pb Zr 0.52 Ti 0.48 O 3 (PZT) films of thickness ∼1μm prepared by a sol-gel process were wet-chemically patterned using an economical and effective etch process. The etch recipe provided excellent etch control, minimized undercut, preserved the photoresist mask, and effectively removed the residues on the etched surfaces. A high etch rate (200nm∕min), high selectivity with respect to photoresist, and limited undercutting (1.5:1, lateral: thickness) were obtained. The patterned PZT films exhibited good ferroelectric properties in terms of larger saturation polarization, Pmax of ∼53μC∕cm2 at an applied field of 1MV∕cm, higher remnant polarization Pr of ∼30μC∕cm2 for a coercive field of ∼150kV∕cm, fatigue-free characteristics up to ⩾1010 switching cycles, and a low leakage current density of 10−6A∕cm2 at 200×105kV∕cm.
Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content (2003)

Our objective was to determine how 8% weight loss influences subcutaneous, intra-abdominal, and liver fat (LFAT), as well as features of insulin resistance, in obese women with high versus low LFAT. A total of 23 women with previous gestational diabetes were divided into groups of high (9.4 +/- 1.4%) and low (3.3 +/- 0.4%) LFAT based on their median LFAT (5%) measured with proton spectroscopy. Both groups were similar with respect to age, BMI, and intra-abdominal and subcutaneous fat. Before weight loss, women with high LFAT had higher fasting serum insulin and triglyceride concentrations than women with low LFAT. At baseline, LFAT correlated with the percent of fat (r = 0.44, P < 0.05) and saturated fat (r = 0.45, P < 0.05) of total caloric intake but not intra-abdominal or subcutaneous fat or fasting serum free fatty acids. Weight loss was similar between the groups (high LFAT -7.4 +/- 0.2 vs. low LFAT -7.7 +/- 0.3 kg). LFAT decreased from 9.4 +/- 1.4 to 4.8 +/- 0.7% (P < 0.001) in women with high LFAT and from 3.3 +/- 0.4 to 2.0 +/- 0.2% (P < 0.001) in women with low LFAT. The absolute decrease in LFAT was significantly higher in women with high than low LFAT (-4.6 +/- 1.0 vs. -1.3 +/- 0.3%, P < 0.005). The decrease in LFAT was closely correlated with baseline LFAT (r = -0.85, P < 0.001) but not with changes in the volumes of intra-abdominal or subcutaneous fat depots, which decreased similarly in both groups. LFAT appears to be related to the amount of fat in the diet rather than the size of endogenous fat depots in obese women. Women with initially high LFAT lost more LFAT by similar weight loss than those with low LFAT, although both groups lost similar amounts of subcutaneous and intra-abdominal fat. These data suggest that LFAT is regulated by factors other than intra-abdominal and subcutaneous fat. Therefore, LFAT does not appear to simply reflect the size of endogenous fat stores.
A dynamically adaptable bus architecture for trading-off among performance, consumption and dependability in Cyber-Physical Systems (2014)

Cyber-Physical Systems need to handle increasingly complex tasks, which additionally, may have variable operating conditions over time. Therefore, dynamic resource management to adapt the system to different needs is required. In this paper, a new bus-based architecture, called ARTICo <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , which by means of Dynamic Partial Reconfiguration, allows the replication of hardware tasks to support module redundancy, multi-thread operation or dual-rail solutions for enhanced side-channel attack protection is presented. A configuration-aware data transaction unit permits data dispatching to more than one module in parallel, or provide coalesced data dispatching among different units to maximize the advantages of burst transactions. The selection of a given configuration is application independent but context-aware, which may be achieved by the combination of a multi-thread model similar to the CUDA kernel model specification, combined with a dynamic thread/task/kernel scheduler. A multi-kernel application for face recognition is used as an application example to show one scenario of the ARTICo <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> architecture.
PV electrification in India and China: the NREL's experience in international cooperation (1998)

The US Department of Energy (DOE) through its National Renewable Energy Laboratory (NREL) has initiated rural development projects in India and China to demonstrate the viability of photovoltaics in meeting the needs of the rural masses for cost-effective and reliable electricity. This paper contains details of the major projects in the two countries, along with descriptions of the implemented photovoltaic systems and lessons learned to date. The successful outcome of these projects will allow duplication of the experiences in other developing areas of the world. © 1998 John Wiley & Sons, Ltd.
The PolariX-TDS Project: Bead-Pull Measurements and High-Power Test on the Prototype (2019)

A collaboration between DESY, PSI and CERN has been established to develop and build an advanced modular X- band transverse deflection structure (TDS) system with the new feature of providing variable polarization of the deflecting force. The prototype of the novel X-band TDS, the Polarizable X-band (PolariX) TDS, was fabricated at PSI following the high-precision tuning-free production process developed for the C-band Linac of the SwissFEL project. Bead-pull RF measurements were also performed at PSI to verify, in particular, that the polarization of the dipole fields does not have any rotation along the structure. The high-power test was performed at CERN and now the TDS is at DESY and has been installed in FLASHForward, where the first streaking experience with beam will be accomplished. We summarize in this paper the status of the project, the results of the bead-pull measurements and the high power test.
CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia (2016)

The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1 fusion gene. A frequent concomitant event is the loss of the residual ETV6 allele suggesting a critical role for the ETV6 transcriptional repressor in the etiology of this cancer. However, the precise mechanism through which loss of functional ETV6 contributes to disease pathogenesis is still unclear. To investigate the impact of ETV6 loss on the transcriptional network and to identify new transcriptional targets of ETV6, we used whole transcriptome analysis of both pre-B leukemic cell lines and patients combined with chromatin immunoprecipitation. Using this integrative approach, we identified 4 novel direct ETV6 target genes: CLIC5, BIRC7, ANGPTL2 and WBP1L To further evaluate the role of chloride intracellular channel protein CLIC5 in leukemogenesis, we generated cell lines overexpressing CLIC5 and demonstrated an increased resistance to hydrogen peroxide-induced apoptosis. We further described the implications of CLIC5's ion channel activity in lysosomal-mediated cell death, possibly by modulating the function of the transferrin receptor with which it colocalizes intracellularly. For the first time, we showed that loss of ETV6 leads to significant overexpression of CLIC5, which in turn leads to decreased lysosome-mediated apoptosis. Our data suggest that heightened CLIC5 activity could promote a permissive environment for oxidative stress-induced DNA damage accumulation, and thereby contribute to leukemogenesis.