gebhart/patrepeval huggingface dataset:
The Effects of ZinMet Brand Liquid Zinc Methionine on Feedlot Performance and Carcass Merit in Crossbred Yearling Steers,, (2008)

The use of liquid zinc methionine for yearling steers was evaluated. In Exp. 1, a control (CON) treatment provided 15, 40, and 100 mg/kg (DM basis) of Cu, Mn, and Zn from inorganic sources, and an organic trace mineral (ORG) treatment provided 10, 20, and 40 mg/kg (DM basis) of Cu, Mn, and Zn from Cu betaine, Mn methionine, and Zn methionine, respectively. Finished BW, ADG, DMI, and feed efficiency were similar (P > 0.30) for CON and ORG treatments. In Exp. 2, a CON treatment provided 100 mg/kg DM supplemental Zn from Zn sulfate and an ORG treatment provided 40 mg/kg DM supplemental Zn from Zn methionine and 60 mg/kg DM supplemental Zn from Zn sulfate. Body weight was increased (P < 0.09) at d 35 for steers fed ORG as compared with steers fed CON. Finished BW, ADG, DMI, and feed efficiency from d 1 through harvest were similar (P > 0.58) for CON and ORG treatments. Average daily gain from d 1 through 34 was improved (P < 0.05) for the ORG treatment as compared with the CON treatment (1.70 vs. 1.55 kg/d per head, respectively). Carcass weight, dressing percentage, YG, QG, and liver abscess rate were similar for CON and ORG treatments for both experiments. These data indicate that overall feedlot performance and carcass merit were similar for yearling steers fed CON and ORG trace mineral sources.
En Block Resection of a Large Hepatocellular Carcinoma Involving the Caudal Vena Cava in a Dog (2010)

A 13-year-old neutered female Shih Tzu was referred for investigation of a cranial abdominal mass. Investigations including conventional radiography, abdominal ultrasonography and computed tomography confirmed the mass in the caudate lobe of the liver. As a collateral vein originating from the caudal vena cava (CVC) communicated with the azygos vein, the CVC was ligated and transected cranial to the right renal vein and cranial to the mass under temporary occlusion of the thoracic descending aorta and posthepatic CVC. The mass combined with the CVC was excised. The mass was confirmed as hepatocellular carcinoma (HCC). This report describes the first case with successful en bloc resection of a large HCC involving the CVC in a dog.
Superoxide Production by Neutrophils in a Model of Adult Respiratory Distress Syndrome (1988)

Neutrophils (polymorphonuclear leukocytes [PMNs]) are thought to contribute to the pathophysiology of adult respiratory distress syndrome (ARDS) by the release of toxic oxygen metabolites. This study investigated superoxide production by circulating and bronchoalveolar lavage (BAL) PMNs in a rat model of ARDS induced by chronic Escherichia coli (lipopolysaccharide) endotoxemia. Superoxide production was stimulated by fmet-leu-phe, opsonized zymosan, and phorbol myristate acetate. Circulating and BAL PMNs from lipopolysaccharide-infused rats compared with PMNs from control rats are primed for nonselective increased superoxide production. The BAL PMNs are not only partially primed to release superoxide on adherence, they concomitantly have a depressed superoxide response to a phagocytic (opsonized zymosan) stimulus. These PMN responses may partially explain both the pulmonary injury and the increased susceptibility to pulmonary infection seen in patients with ARDS.
Mutations that alter the helix‐turn‐helix region of the spollAC protein: a Bacillus subtilis sporulation‐specific sigma factor (1989)

It has previously been shown that spollAC561, a mutation that diminishes the incidence of sporulation by more than six orders of magnitude, alters the residue at position 13 of the helix-turn-helix region of the sporulation-specific sigma factor encoded by spollAC from valine to methionine (Yudkin, 1987b). We have now found that four spontaneous revertants, which sporulate at an incidence of 30-60%, all contain transitions within the codon that was altered by spo-561. The mutant methionine is replaced by isoleucine in two revertants, and by threonine in the other two.
The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis (2022)

In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.
Plasma spark discharge reactor and durable electrode (2023)

A plasma spark discharge reactor for treating water. The plasma spark discharge reactor comprises a HV electrode with a head and ground electrode that surrounds at least a portion of the HV electrode. A passage for gas may pass through the reactor to a location proximate to the head to provide controlled formation of gas bubbles in order to facilitate the plasma spark discharge in a liquid environment.
Why biodiversity is important to oceanography: potential roles of genetic, species, and trophic diversity in pelagic ecosystem processes (2006)

The functioning of the global ecosystem is mediated in large part by pelagic marine organisms through their influence on biomass production, elemental cycling, and atmospheric composition. Growing theoretical and empirical evidence suggests that the stability and functioning of this complex system may depend, not only on aggregate biomass and production of pelagic producers and consumers, but also on the composition and richness of taxa within those compartments. Yet rigorous experimental tests of relationships between diversity and these aspects of pelagic ecosystem functioning are virtually unknown. Here, we argue for more attention to such research, and we marshal preliminary evidence that several mechanisms underlying diversity effects on ecosystem processes in marine benthic and terrestrial systems also may operate in pelagic systems. We review selected examples of how genetic, species, and functional group diversity may affect ocean ecosystem processes. We consider 3 types of examples that detail how (1) producer richness or composition can directly affect ecosystem processes, (2) consumer diversity can directly and indirectly affect these same processes, and (3) diversity at and below the species level can reduce variation of communities through time and enhance their resistance to perturbations. We suggest several promising avenues for assessing the role of biodiversity in pelagic ecosystems. Understanding and predicting responses of the global ocean ecosystem to accelerating climate and environmental change will be enhanced by more explicit and systematic attention to the functional diversity of microbial and macroscopic marine life.
Effect of vaccination with recombinant canine distemper virus vaccine immediately before exposure under shelter-like conditions. (2006)

Vaccination with modified-live virus (MLV) canine distemper virus (CDV) vaccine has historically been recommended for animals in high-risk environments because of the rapid onset of immunity following vaccination. Recombinant CDV (rCDV) vaccine was deemed a suitable alternative to MLV-CDV vaccination in pet dogs, but insufficient data precluded its use where CDV was a serious threat to puppies, such as in shelters, kennels, and pet stores. In this study, dogs experimentally challenged hours after a single dose of rCDV or MLV vaccine became sick but recovered, whereas unvaccinated dogs became sick and died. Dogs vaccinated with a single dose of rCDV or MLV vaccine 1 week before being experimentally challenged remained healthy and showed no clinical signs. Dogs given one dose of rCDV vaccine hours before being placed in a CDV-contaminated environment did not become sick. These findings support the hypothesis that rCDV vaccine has a similar time-to-immunity as MLV-CDV vaccines and can likewise protect dogs in high-risk environments after one dose.
Measurement Parameters Optimized for Sequential Multilateration in Calibrating a Machine Tool with a DOE Method (2016)

Improving volumetric error compensation is one of the machine tool user’s key objectives. Smart compensation is bound to calibration accuracy. Calibration quality depends largely on its setup factors. An evaluation criterion is thus required to test the quality of the compensation deduced from these setup factors. The residual error map, which characterizes post-compensation machine errors, is therefore chosen and then needs to be evaluated. In this study, the translation axes of a machine tool were calibrated with a multilateration tracking laser interferometer. In order to optimize such measurements, the residual error map was then characterized by two appliances: a laser interferometer and the tracking laser already employed for the calibration, using for that purpose the sequential multilateration technique. This research work thus aimed to obtain a smart setup of parameters of machine tool calibration analyzing these two residual error maps through the Design Of Experiment (DOE) method. To achieve this goal, the first step was to define the setup parameters for calibrating a compact machine tool with a multilateration tracking laser. The second step was to define both of the measurement processes that are employed to estimate the residual error map. The third step was to obtain the optimized setup parameters using the DOE method.
L'assurance vie - aspects réglementaires (2012)

L’assurance vie est un des placements preferes des Francais. Cet ouvrage analyse l’assurance vie sur les plans reglementaire et technique tant du point de vue du contrat (familier au juriste) que de l’entreprise (familier a l’actuaire). Il comporte deux parties :
	– l’assurance vie « classique », avec une presentation technique qui vise a eclairer – pour des non techniciens – le Code des assurances : contrats « en cas de vie », contrats « en cas de deces », et combinaison des deux pour arriver aux contrats d’assurance vie modernes, voire de troisieme generation comme les variables annuities ;
	– les regimes speciaux, notamment les regimes 441 et PERP.

	Si les juristes savent comment rediger une clause beneficiaire, ils ne savent pas comment fonctionne reellement un contrat d’assurance vie. Reciproquement, les techniciens connaissent mal le cadre juridique dans lequel ils evoluent. Le livre se positionne entre l’ouvrage purement juridique et l’ouvrage technique : il doit permettre a des juristes de comprendre certains enjeux techniques et a des techniciens de mieux comprendre l’environnement juridique.

	Il repond ainsi aux besoins des professionnels – banquiers, assureurs, mutuelles, institutions de prevoyance, actuaires, experts financiers,
	consultants, juristes d’entreprise – comme des etudiants en assurance ou en droit bancaire.
Abstract 9845: Novel Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis (2021)

Background: The efficacy and safety of novel oral anticoagulants (NOACs) compared to the current guideline-recommended vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients undergoing transcatheter aortic valve replacement (TAVR) has not been well established. We pooled evidence from all available studies to assess the risks and benefits of this drug class. Methods: We queried electronic databases (MEDLINE, Scopus, and Cochrane central) up until 15 th May 2021 for studies comparing NOACs to VKAs in AF patients undergoing TAVR. Results from studies were presented as risk ratios (RR) with 95% confidence intervals (CI) and pooled using a random-effects model. Subgroup analysis by study design and meta-regression analysis were performed to explore heterogeneity. Results: A total of 12 studies (4 RCTs and 8 retrospective observational) containing 13,815 patients (mean age 81.1 years; 50.1% men) were identified and included in the analysis. Pooled analysis revealed no significant difference between NOACs and VKAs in terms of stroke or systemic embolism (RR 0.83; p=0.34), major bleeding (RR 0.84; p=0.30), intracranial hemorrhage (RR 0.72; p=0.60), all-cause mortality (RR 0.71; p=0.15), and myocardial infarction (RR 1.34; p=0.32) at a mean length of follow-up of 15.1 months. RCTs and observational studies did not significantly differ across outcomes on subgroup analysis. Meta-regression analysis found heterogeneity in all-cause mortality to be significantly explained by percentage of males (coefficient: 0.049, p=0.007), mean age (coefficient: 0.221, p&lt;0.001), and CHA2DS2-VASc score (coefficient: -1.657, p&lt;0.001). Conclusions: This meta-analysis suggests that outcomes with NOACs do not significantly differ compared to VKAs following TAVR in patients with AF. Future RCTs may help provide a clearer answer.
<title>Microendoscopy of the nasal cavity and the paranasal sinuses via their natural orifices</title> (1992)

Microendoscopy of the nasal cavities and the para-nasal sinuses is a new and atraumatical method to investigate these anatomical regions which were previously inaccessible for direct visual inspection due to their special topography. By means of superfine flexible and partly actively tip controllable fiberscopes the procedure only requires local anesthesia. Microendoscopes with outside diameters of 290 to 1600 micrometers are inserted through the natural orifices or ducts of the para-nasal sinuses partly guided by actively steerable microcatheters of 5 to 9 F. The eyepiece of the scope is connected with a chip-camera simultaneously carrying the endoscopic images onto a monitor system. This new procedure contributes to a better presurgical planning and risk assessment of endonasal sinus surgery and to the avoiding of repeated x-ray imaging during the therapeutic follow up of acute and chronic para-nasal infections. Furthermore, in combination with fiber delivered laser systems, it forms the basis and technical precondition for `minimal invasive laser-assisted microsurgery' of these anatomic regions.
Loadable kernel modules: the new frontier for indident response (2001)

What would you do if traditional incident response tools completely failed during an investigation? That is exactly what I experienced when up against a loaded evil kernel module. Loadable kernel modules are changing the techniques used to perform an incident response because the level of compromise is raised from user space to kernel space. Once the compromise breaches the kernel space, the effects trickle down to any user-space executable resident on the trojaned system. This effect allows an intruder to change the behavior for any command executed on the system without changing the program binaries themselves. With this in mind, any trusted toolkit you transfer to the victim machine will also be automatically compromised. Therefore, I will explain how one malicious kernel module works and describe a couple of tools I developed to cope with the problem.
In vitro ribosome synthesis and evolution through ribosome display (2020)

Directed evolution of the ribosome for expanded substrate incorporation and novel functions is challenging because the requirement of cell viability limits the mutations that can be made. Here we address this challenge by combining cell-free synthesis and assembly of translationally competent ribosomes with ribosome display to develop a fully in vitro methodology for ribosome synthesis and evolution (called RISE). We validate the RISE method by selecting active genotypes from a ~1.7 × 10<sup>7</sup> member library of ribosomal RNA (rRNA) variants, as well as identifying mutant ribosomes resistant to the antibiotic clindamycin from a library of ~4 × 10<sup>3</sup> rRNA variants. We further demonstrate the prevalence of positive epistasis in resistant genotypes, highlighting the importance of such interactions in selecting for new function. We anticipate that RISE will facilitate understanding of molecular translation and enable selection of ribosomes with altered properties.
Study of the DecayBs0→Ds(*)Ds(*) (2007)

We report a study of the decay Bs(0)-->Ds(*)Ds(*) using a data sample corresponding to 1.3 fb(-1) of integrated luminosity collected by the D0 experiment in 2002-2006 during run II of the Fermilab Tevatron collider. One Ds(*) meson was partially reconstructed in the decay Ds-->phi mu nu, and the other Ds(*) meson was identified using the decay Ds-->phi pi where no attempt was made to distinguish Ds and Ds(*) states. For the branching fraction Br(Bs(0)-->Ds(*)Ds(*)) we obtain a 90% C.L. range [0.002,0.080] and central value 0.039(-0.017)(+0.019)(stat)(-0.015)(+0.016)(syst). This was subsequently used to make the most precise estimate of the width difference DeltaGamma(s)CP in the Bs(0)-Bs(0) system: DeltaGamma(s)CP/Gamma(s)=0.079(-0.035)(+0.038)(stat)(-0.030)(+0.031)(syst).
Microbeam Radiotherapy—A Novel Therapeutic Approach to Overcome Radioresistance and Enhance Anti-Tumour Response in Melanoma (2021)

Melanoma is the deadliest type of skin cancer, due to its invasiveness and limited treatment efficacy. The main therapy for primary melanoma and solitary organ metastases is wide excision. Adjuvant therapy, such as chemotherapy and targeted therapies are mainly used for disseminated disease. Radiotherapy (RT) is a powerful treatment option used in more than 50% of cancer patients, however, conventional RT alone is unable to eradicate melanoma. Its general radioresistance is attributed to overexpression of repair genes in combination with cascades of biochemical repair mechanisms. A novel sophisticated technique based on synchrotron-generated, spatially fractionated RT, called Microbeam Radiation Therapy (MRT), has been shown to overcome these treatment limitations by allowing increased dose delivery. With MRT, a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose microbeams that are tens of micrometres wide and spaced a few hundred micrometres apart. Different preclinical models demonstrated that MRT has the potential to completely ablate tumours, or significantly improve tumour control while dramatically reducing normal tissue toxicity. Here, we discuss the role of conventional RT-induced immunity and the potential for MRT to enhance local and systemic anti-tumour immune responses. Comparative gene expression analysis from preclinical tumour models indicated a specific gene signature for an 'MRT-induced immune effect'. This focused review highlights the potential of MRT to overcome the inherent radioresistance of melanoma which could be further enhanced for future clinical use with combined treatment strategies, in particular, immunotherapy.
Magnetic Nanoparticles and Magnetic Field Exposure Enhances Chondrogenesis of Human Adipose Derived Mesenchymal Stem Cells But Not of Wharton Jelly Mesenchymal Stem Cells (2021)

<b>Purpose:</b> Iron oxide based magnetic nanoparticles (MNP) are versatile tools in biology and medicine. Adipose derived mesenchymal stem cells (ADSC) and Wharton Jelly mesenchymal stem cells (WJMSC) are currently tested in different strategies for regenerative regenerative medicine (RM) purposes. Their superiority compared to other mesenchymal stem cell consists in larger availability, and superior proliferative and differentiation potential. Magnetic field (MF) exposure of MNP-loaded ADSC has been proposed as a method to deliver mechanical stimulation for increasing conversion to musculoskeletal lineages. In this study, we investigated comparatively chondrogenic conversion of ADSC-MNP and WJMSC with or without MF exposure in order to identify the most appropriate cell source and differentiation protocol for future cartilage engineering strategies. <b>Methods:</b> Human primary ADSC and WJMSC from various donors were loaded with proprietary uncoated MNP. The <i>in vitro</i> effect on proliferation and cellular senescence (beta galactosidase assay) in long term culture was assessed. <i>In vitro</i> chondrogenic differentiation in pellet culture system, with or without MF exposure, was assessed using pellet histology (Safranin O staining) as well as quantitative evaluation of glycosaminoglycan (GAG) deposition per cell. <b>Results:</b> ADSC-MNP complexes displayed superior proliferative capability and decreased senescence after long term (28 days) culture <i>in vitro</i> compared to non-loaded ADSC and to WJMSC-MNP. Significant increase in chondrogenesis conversion in terms of GAG/cell ratio could be observed in ADSC-MNP. MF exposure increased glycosaminoglycan deposition in MNP-loaded ADSC, but not in WJMSC. <b>Conclusion:</b> ADSC-MNP display decreased cellular senescence and superior chondrogenic capability <i>in vitro</i> compared to non-loaded cells as well as to WJMSC-MNP. MF exposure further increases ADSC-MNP chondrogenesis in ADSC, but not in WJMSC. Loading ADSC with MNP can derive a successful procedure for obtaining improved chondrogenesis in ADSC. Further <i>in vivo</i> studies are needed to confirm the utility of ADSC-MNP complexes for cartilage engineering.
High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells (2015)

Hematopoietic stem cells can self-renew and differentiate into all blood cell types. The transcription factor GATA-2 is expressed in both hematopoietic stem and progenitor cells and is essential for cell proliferation, survival, and differentiation. Recently, evidence from studies of aplastic anemia, MonoMAC syndrome, and lung cancer has demonstrated a mechanistic link between GATA-2 and human pathophysiology. GATA-2-dependent disease processes have been extensively analyzed; however, the transcriptional mechanisms upstream of GATA-2 remain less understood. Here, we conducted high-throughput small-interfering-RNA (siRNA) library screening and showed that YN-1, a human erythroleukemia cell line, expressed high levels of GATA-2 following the activation of the hematopoietic-specific 1S promoter. As transient luciferase reporter assay in YN-1 cells revealed the highest promoter activity in the 1S promoter fused with GATA-2 intronic enhancer (+9.9 kb/1S); therefore, we established a cell line capable of stably expressing +9.9 kb/1S-Luciferase. Subsequently, we screened 995 transcription factor genes and revealed that CITED2 acts as a GATA-2 activator in human hematopoietic cells. These results provide novel insights into and further identify the regulatory mechanism of GATA-2.
Hemodynamic Effects of Fenofibrate and Coenzyme Q10 in Type 2 Diabetic Subjects With Left Ventricular Diastolic Dysfunction (2008)

In type 2 diabetic subjects with LVDD, neither fenofibrate nor CoQ, alone or in combination, improved diastolic function significantly. However, fenofibrate and CoQ independently and interactively lowered 24-h blood pressure, and fenofibrate alone reduced 24-h HR.