gebhart/patrepeval huggingface dataset:
Overexpression of Parathyroid Hormone-Related Protein Inhibits Pancreatic β-Cell Death In Vivo and In Vitro (2002)

Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a concomitant increase in beta-cell proliferation rate or enlargement of individual beta-cell size. Thus, the mechanism for increased beta-cell mass is unknown. In this study, we demonstrated that beta-cells of transgenic mice are resistant to the cytotoxic effects of streptozotocin (STZ) in vivo, as documented by a sixfold reduction in the rate of STZ-induced beta-cell death in RIP-PTHrP mice relative to their normal siblings. The reduced cell death in transgenic mice is due neither to their increased islet mass nor to a decrease in their sensing of STZ, but rather results from PTHrP-induced resistance to beta-cell death. This is also demonstrated in vitro by markedly reduced cell death rates observed in beta-cells of transgenic mice compared with normal mice when cultured in the absence of serum and glucose or in the presence of STZ. Finally, we demonstrated that NH(2)-terminal PTHrP inhibits beta-cell death. These findings support the concept that PTHrP overexpression increases islet mass in transgenic mice through inhibition of beta-cell death.
Focal Atrial Tachycardia Originating from the Right Atrial Appendage: First Successful Cryoballoon Isolation (2008)

Focal atrial tachycardias (AT) can arise from the right atrial appendage (RAA). However, conventional catheter mapping and radiofrequency (RF) ablation inside the RAA is associated with the risk of cardiac perforation. The cryoballoon catheter represents a novel ablation device that was originally developed to facilitate pulmonary vein isolation. This report describes the first successful RAA isolation using a cryoballoon in a patient with an incessant focal RAA AT despite previous irrigated tip endo- and epicardial ablation attempts. Further, cryoballoon ablation targets beyond pulmonary veins may evolve.
This is it ! : Indicating and looking in collaborative work at distance (2010)

Little is known of the interplay between deixis and eye movements in remote collaboration. This paper presents quantitative results from an experiment where participant pairs had to collaborate at a distance using chat tools that differed in the way messages could be enriched with spatial information from the map in the shared workspace. We studied how the availability of what we defined as an Explicit Referencing mechanism (ER) affected the coordination of the eye movements of the participants. The manipulation of the availability of ER did not produce any significant difference on the gaze coupling. However, we found a primary relation between the pairs recurrence of eye movements and their task performance. Implications for design are discussed.
The problem with checklists (2015)

‘The Problem with…’ series covers controversial topics related to efforts to improve healthcare quality, including widely recommended but deceptively difficult strategies for improvement and pervasive problems that seem to resist solution.

Since the seminal studies by Gawande and colleagues1 and Pronovost et al ,2 checklists have become the go-to solution for a vast range of patient safety and quality issues in healthcare. Some see them as a quick and obvious solution to a relatively straightforward problem. For others, they illustrate a failure to understand and address the complex challenges in patient safety and quality improvement. Indeed, successes3 and failures4–6 illustrate an underlying difficulty with understanding precisely why checklists work in some cases but not in others. A recent viewpoint summarises the varying applications of checklists in aviation and healthcare, reflecting upon the dangers of making assumptions about their ‘ubiquitous utility’.7 This provided a timely “The Problem with…”8 opportunity, in which we consider the narratives that often surround the complex challenges faced in designing and implementing a successful checklist, and the science used to explore it.

The apparent simplicity of a checklist is understandingly tempting, with some narratives suggesting that their adoption can be used to effectively address what would appear to be intractable, complex and potentially painful systems issues. However, this simple narrative does not always reflect an understanding of the problems needing to be solved, how best to solve them or indeed the intricacies surrounding the implementation, use and impact of such a simple looking tool. More likely, what we face in introducing a checklist is a rather more complex story of gains and losses, procedural interactions and sociocultural balances (see table 1). This ‘simple’ versus ‘complex’ narrative can also be seen in the frequent aviation analogies, which imply that checklists prevented accidents …
Expression of a Patatin-Like Protein in the Anthers of Potato and Sweet Pepper Flowers (1989)

Patatin, the major glycoprotein in potato tubers, is encoded by a multigene family. RNA and protein analyses reveal that a homologous mRNA and an immunologically cross-reacting protein can be found in potato flowers, which is similar to patatin in that it displays a lipid acyl hydrolase activity. The patatin-like protein found in flowers has a higher molecular weight than the authentic tuber patatin. Deglycosylation experiments show that this is not due to differences in the glycosylation pattern. Immunocytochemical analysis shows the patatin-like protein to be present only in the epidermal cell layer of the anther, the exothecium, and in petals of potato flowers. Furthermore, the fact that a patatin-like protein can be detected in a similar tissue in sweet pepper, another solanaceous plant, could give a clue concerning the evolutionary origin of patatin.
Fabrication of Organic Light Emitting Diodes by Flash Vaporization (2010)

Organic Light Emitting Diodes (OLED) have high efficiency, low power consumption and wide color gamut which makes them an excellent choice for solid state lights (SSL) and displays.OLED displays are the first choice in high end portable electronic display and OLED SSL are making inroads into commercial lighting.High production cost due to manufacturing limitations of a crucible based system is one of the main reasons why OLEDs are not mainstream technology.The objective of this thesis is to demonstrate OLEDs fabricated by Kodak Vapor Injection Source (KVIS).KVIS is an on demand flash vaporization system, where the rate of deposition is governed by the amount of material fed rather than the crucible temperature.Conventionally, OLED fabrication is done by vacuum thermal evaporation, where organic
Studies on organophosphorus compounds: XVIII. Synthesis and reactions of α-sulfonylphosphonates (1987)

A new facile synthetic method for the preparation of α-sulfonylphosphonates based on the phosphorylation of carbanion derived from sulfones bearing an active methylene group was described. Condensation of the resulting sulfonyl phosphorus ylides with aldehyde or ketone in situ gives α,β-unsaturated sulfones with satisfactory yields.
Research on modeling and simulation of hybrid electric vehicle energy control system (2005)

In this paper pre-transmission coupled parallel hybrid electric vehicle (PHEV) dynamic system energy control structural model is built according to the development requirement of hybrid electric light off-road vehicles and the vehicle's dynamic system form, based on the model a whole vehicle driving dynamics model is built in order to research the dynamic performance and fuel economy. The engine test bench testing data are fitted using of extreme value theory and surface fitting method, and the engine universal characteristic curves and OOL mathematic model are built. Besides, driving induction motor mathematic model and driving battery SOC mathematic model are built. Then vehicle dynamics is simulated according to the least fuel consumption and battery charging and discharging balance energy distributing rule. The simulation result indicated the least engine fuel consumption as well as battery balance. The accuracy of models is proved by the vehicle's road tests according to proposed control method.
Virtual reality for rehabilitation in Parkinson's disease (2013)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effectiveness of virtual reality (VR) exercise interventions for rehabilitation in patients with Parkinson's disease (PD). VR exercise interventions will be compared with usual care, a placebo control intervention, or any other exercise intervention without VR. Our primary objective is to determine the effect of VR exercise interventions on gait and balance in patients with PD. Our secondary objectives are to determine the effects of VR exercise interventions on (1) global motor function, (2) cognitive function, (3) activities of daily living, (4) quality of life, (5) number and types of adverse events, and (6) therapy adherence in patients with PD.
ChemInform Abstract: A Facile One‐Pot Preparation of Organoselanyltrifluoroborates from Dihalobenzenes and Their Cross‐Coupling Reaction. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fuel-Dithering Optimization of Efficiency of TWC on Natural Gas IC Engine (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Steady-state, transient and dithering characteristics of emission conversion efficiencies of three-way catalysts on natural gas IC engine were investigated experimentally on a single-cylinder CFR engine test bench. Steady-state runs were conducted as references for specific engine emission levels and corresponding catalyst capacities. The steady-state data showed that conversion of HC will be the major problem since conversion of HC was effective only for a very narrow range of exhaust mixture. Unsteady exploration runs with both lean-to-rich and rich-to-lean transitions were conducted. These results were interpreted with a time scale analysis, according to which a qualitative oxygen storage model was proposed featuring the difference between oxygen absorption and desorption rates on the palladium catalysts. Additionally this oxygen storage model also revealed information about parameter selection for dithering to achieve optimal emission operation where all three, HC (mostly CH&lt;sub&gt;4&lt;/sub&gt;), CO and NOx are simultaneously reduced.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Dithering with different midpoint Lambda values, frequencies and amplitudes were further investigated. The results showed that the optimal dithering Lambda midpoint resided in slightly rich engine charge. An optimal intermediate frequency was found corresponding to the characteristic time of the emission-favorable Lambda zone as suggested by the oxygen storage model. An intermediate optimal amplitude was also found due to that extra HC and CO emission coming from the richer side lowered down the overall conversion efficiencies when dithering with higher amplitudes. The difference between emission data after the first catalyst and after both indicated that more catalyst capacities are critical for HC conversion.&lt;/div&gt;&lt;/div&gt;
The right to read (1997)

article Free AccessThe right to read Author: Richard Stallman View Profile Authors Info & Claims Communications of the ACMVolume 40Issue 2Feb. 1997 pp 85–87https://doi.org/10.1145/253671.253726Published:01 February 1997Publication History 11citation820DownloadsMetricsTotal Citations11Total Downloads820Last 12 Months55Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Upregulation of LPS‐induced chemokine KC expression by 15‐deoxy‐Δ12,14‐prostaglandin J2 in mouse peritoneal macrophages (2005)

15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) was initially identified as a high affinity natural ligand for the peroxisome proliferator-activated receptor (PPAR)-gamma. Recent studies have shown that it has a potent anti-inflammatory effect by attenuating the expression of proinflammatory mediators in activated macrophages, mainly through the inhibition of nuclear factor (NF)-kappaB-dependent transcription of inflammatory genes. In this study, we investigated the synergistic effect of 15d-PGJ(2) on the expression of LPS-induced chemokine KC mRNA in mouse peritoneal macrophages. The time course of KC mRNA expression in cells stimulated with 15d-PGJ(2) plus LPS simultaneously (15d-PGJ(2)/LPS) showed similar patterns to the cells treated with LPS alone, and 15d-PGJ(2) had no effect on the stability of LPS-induced KC mRNA expression. Although NF-kappaB activity in cells treated with LPS was augmented by 15d-PGJ(2), pyrrolidone dithiocarbamate (PDTC) did not block the synergistic effect of 15d-PGJ(2) on LPS-induced KC mRNA expression. However, the synergistic effect of 15d-PGJ(2) was markedly inhibited when the macrophages were treated with a inhibitor of the mitogen-activated protein kinase (MAPK) signalling pathway, 2'-amino-3'-methoxyflavine (PD98059). Therefore, the mechanism of synergistic action of 15d-PGJ(2) on the expression of LPS-induced KC mRNA in mouse peritoneal macrophages is possibly related to the MAPK signalling pathway, not to NF-kappaB activation. These data may contribute to unravelling some of the different mechanisms contrary to the anti-inflammatory effect of 15d-PGJ(2).
Malignant Phyllodes Tumor (2001)

The study aims to evaluate the survival and prognosis of patients with malignant phyllodes tumor. Between 1982 and 1998, 37 women with malignant phyllodes tumor were treated at the Regional Cancer Center, Trivandrum. Twelve patients were recurrent. Survival was estimated using the Kaplan-Meier method. Patient, disease, and treatment factors were compared using log-rank test. The Cox-proportional hazard model was employed to identify the prognostic factors. Thirty-six patients had surgery. Twenty-five patients received postoperative radiotherapy, and 2 received chemotherapy in addition. The median follow-up was 43 months (range 1-170 months). Eight patients failed locally, and 7 of these were successfully salvaged by surgery. The 5-year overall survival was 74.2% (95% CI, 0.44 to 0.89), whereas 5-year disease-free survival was 59.6% (95% CI, 0.39 to 0.7). The margin of surgical excision was found to be the only independent prognostic factor (p=0.003). However, patients with tumor size more than 5 cm (hazard ratio 2.9) were found to have increased hazard, whereas those receiving adjuvant radiotherapy (hazard ratio 0.6), married women (hazard ratio 0.4), and those women over the age of 35 years (hazard ratio 0.7) showed a decreased hazards. Cystosarcoma phyllodes is a rare malignancy of the female breast. Surgery with adequate margins is the primary treatment. Adjuvant radiotherapy appears to improve the disease-free survival.
Studies on the solid circulation rate and gas bypassing in spouted fluid‐bed with a draft tube (1983)

Abstract Experiments were performed in a 28.6 cm diameter transparent semicircular vessel with a 9.6 cm diameter draft tube using polyethylene beads (ρ s = 0.91 g/cm 3 ) and hollow epoxy spheres (ρ s = 0.21 g/cm 3 ) as the bed material to study the effect of operating conditions, the distributor plate design, and the draft tube inlet configurations on the solid circulation rate and the gas distribution between the downcomer and the draft tube. Solid circulation rate was found to be strongly affected by the design configuration at the bottom of the draft tube and the downcomer, which provided different gas bypassing characteristics and resulted in different amount of aeration in the downcomer region.
Interactions of retinol with binding proteins: Studies with retinol-binding protein and with transthyretin (1992)

The interactions within the molecular complex in which retinol circulates in blood were studied. To monitor binding between retinol-binding protein (RBP) and transthyretin (TTR), TTR was labeled with a long-lived fluorescence probe (pyrene). Changes in the rotational volume of TTR following its association with RBP were monitored by fluorescence anisotropy of the probe. Titration of TTR with holo-RBP revealed the presence of 1.5 binding sites characterized by a dissociation constant Kd = 0.07 microM. At 0.15 M NaCl, binding of RBP to TTR showed an absolute requirement for the native ligand, retinol. At higher ionic strength (0.5 M NaCl), RBP complexed with retinal also bound to TTR with high affinity (Kd = 0.134 microM). RBP containing retinoic acid did not bind to TTR even at the high salt concentration. The data suggest that the TTR binding site on RBP is in close proximity to the retinoid binding site and that the head group of retinoic acid, when bound to RBP, presents steric hindrance for the interactions with TTR. The implications of the data for selectivity in retinoid transport in the circulation are discussed. The kinetics of the steps leading to complete dissociation of the retinol-RBP-TTR complex was also studied. The first step of this process was dissociation of retinol, which had a rate constant of 0.06/min. Following loss of retinol, the two proteins dissociate. The rate of dissociation is slow (k = 0.055/h), however, indicating that the complex apo-RBP-TTR will be an important factor in regulating serum levels of retinol.
Analysis ofp−nLuminescence in Zn-Doped GaP (1961)

$p\ensuremath{-}n$ luminescence and photoluminescence of Zn-doped GaP are investigated. Spectral distributions and the light output as a function of temperature and excitation density are recorded. The light output of the $p\ensuremath{-}n$ luminescence shows a strongly superlinear dependence on excitation density. With rising temperature, the superlinear range shifts to higher excitation densities. Using a three-level model the recombination kinetics are analyzed with the aid of the Klasens code-number method. The analysis given allows an interpretation of the superlinearity and gives a quantitative explanation of the observed shift of the superlinear range with temperature.
Structurally Defined Ring‐Opening and Insertion of Pinacolborane into Aluminium‐Nitrogen Bonds of Sterically Demanding Dialkylaluminium Amides (2020)

Abstract Dialkylaluminium amides i Bu 2 Al(TMP) and i Bu 2 Al(HMDS) can perform catalytic hydroboration of ketones with pinacolborane to form the expected boronic esters. However, repeating the same reactions stoichiometrically without a ketone leads unexpectedly to ring‐opening of pinacolborane and insertion of its open chain into the Al−N(amido) bond. To date there has been limited knowledge on decomposition pathways of HBpin despite its prominent role in hydroboration chemistry. X‐ray crystallography shows these mixed Al−B products [ i Bu 2 Al{OC(Me) 2 C(Me) 2 O}B(H)(NR 2 )] 2 (NR 2 =TMP or HMDS) form dimers with an (AlO) 2 core and terminal B−N bonds. Since the bond retention (B−H) and bond breaking (B−O) in these transformations seemed surprising, DFT calculations run using M11/6‐31G(d,p) gave an energy profile consistent with a σ‐bond metathesis mechanism where London dispersion interactions between i Bu and (amide) Me groups play an important stabilising role in the final outcome.
High first torque harmonic due to insufficient function of dead time compensation in PWM inverters (2007)

A new source for the DC current offset in the PWM inverter-fed loads is found. A significant irregularity in dead time voltage compensation due to a very small offset in phase current measurement is the cause for it. In the phase currents and voltages, high DC offsets appear at low current magnitudes, which lead to a first torque harmonic in the drive. Recommendations how to avoid this effect are given in the paper.
Labeling of Mesenchymal Stem Cells with Bioconjugated Quantum Dots (2010)

Quantum dots (QDs) are semiconductor nanocrystals, and recently they have been shown as effective probes for cell labeling. Due to their unique spectral, physical, and chemical properties, QDs can concurrently tag multiple intercellular and intracellular components of live cells for time ranging from seconds to months. Different color QDs can label different cell components that can be visualized with fluorescent microscopy or in vivo. Here, we provide a detailed protocol for labeling postnatal and differentiated stem/progenitor cells with bioconjugated quantum dots. For example, peptide CGGGRGD is immobilized on CdSe-ZnS QDs with free carboxyl groups. These bioconjugates label selected integrins on cell membrane of human mesenchymal stem cells (hMSCs). QD concentration and incubation time to effectively label hMSCs is optimized. We discovered that bioconjugated QDs effectively label hMSCs not only during population doubling, but also during multi-lineage differentiation into osteoblasts, chondrocytes, and adipocytes. Undifferentiated and differentiated stem cells labeled with bioconjugated QDs can be readily imaged by fluorescent microscopy. Thus, quantum dots represent an effective cell labeling probe and an alternative to organic dyes and fluorescent proteins for cell labeling and cell tracking.
Solvatochromic Dyes as Solvent Polarity Indicators (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvatochromic Dyes as Solvent Polarity IndicatorsChristian ReichardtCite this: Chem. Rev. 1994, 94, 8, 2319–2358Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/cr00032a005https://doi.org/10.1021/cr00032a005research-articleACS PublicationsRequest reuse permissionsArticle Views28620Altmetric-Citations4564LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Palladium-Catalyzed Alkenylation and Alkynylation of ortho-C(sp2)–H Bonds of Benzylamine Picolinamides (2012)

An efficient functionalization of ortho-C(sp(2))-H bonds of picolinamide (PA)-protected benzylamine substrates with a range of vinyl iodides as well as acetylenic bromide is reported. ortho-Phenyl benzoic acid (oPBA) acts as an effective promoter in this reaction system. This method provides a practical strategy to access highly functionalized benzylamine compounds for organic synthesis.