gebhart/patrepeval huggingface dataset:
Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021) (2021)

The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co-workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.
Towards a Framework for Semantic Exploration of Frequent Patterns (2015)

Mining frequent patterns is an essential task in discovering hidden correlations in datasets. Although frequent patterns unveil valuable information, there are some challenges which limits their usability. First, the number of possible patterns is often very large which hinders their effective exploration. Second, patterns with many items are hard to read and the analyst may be unable to understand their meaning. In ad-dition, the only available information about patterns is their support, a very coarse piece of information. In this paper, we are particularly interested in mining datasets that reflect usage patterns of users moving in space and time and for whom demographics attributes are available (age, occupa-tion, etc). Such characteristics are typical of data collected from smart phones, whose analysis has critical business ap-plications nowadays. We propose pattern exploration primi-tives, abstraction and refinement, that use hand-crafted tax-onomies on time, space and user demographics. We show on two real datasets, Nokia and MovieLens, how the use of such taxonomies reduces the size of the pattern space and how demographics enable their semantic exploration. This work opens new perspectives in the semantic exploration of frequent patterns that reflect the behavior of different user communities. 1.
The Surface Emitting Laser Turned of Light: Everybody Has It (2019)

The VCSEL(Vertical Cavity Surface Emitting Laser) is a new type of semiconductor laser and now generating new applications such as high-speed local area networks, computer mice, parallel optical interconnects, laser printers, face recognition systems, and various optical sensors.
Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes. (1980)

This paper describes the specificity of AKR anti-(a) [AKR anti-trinitrophenylated AKR (AKR-TNP)] [AKRa (AKRaAKR TNP)] antisera raised in syngeneic AKR mice against AKRaAKR-TNP cell populations enriched for H-2-restricted aTNP cytotoxic lymphocytes (CTL) by blast-cell isolation. The activity of the antisera resided in the Ig fraction. All antisera were shown to reproducibly react with AKRaAKR-TNP-CTL-containing cell populations in indirect immunofluorescence and all removed the major fraction of CTL in complement-dependent lysis causing a considerable depression of cell-mediated lympholysis. The antisera were nonreactive with alloreactive AKRaC57BL/6 CTL and other H-2-restricted AKR CTL against fluorescein-isothiocyanate-conjugated AKR-target cells. It could be excluded that the antisera contained contaminating antibodies against TNP, TNP-neoantigenic determinants (NAD), or processed CTL-receptor-bound TNP-NAD, thus demonstrating specificity for determinants on T cell receptors of AKRaAKR-TNP CTL. These receptors were produced by the CTL themselves. These observations are interpreted to suggest that AKRa (AKRaAKR-TNP) antisera contain anti-idiotypic antibodies directed against specificity-associated determinants (idiotypes) on T cell receptors of H-2-restricted AKRaAKR-TNP CTL. The antisera provide a new tool to study the genetic control of idiotype expression on H-2-restricted CTL, the biochemistry of T cell receptors, and the regulation of the generation of H-2 restricted CTL on the idiotype level.
Recent advances and trends in roll bonding process and bonding model: A review (2022)

This review presents a thorough survey of the roll bonding process with a focus on the bimetallic bars/tubes as well as the bonding models and criteria. The review aims to provide insight into cold, hot and cryogenic bonding mechanisms at the micro and atomic scale and act as a guide for researchers working on roll bonding, other joining processes and bonding simulation. Meanwhile, the shortcomings of roll bonding processes are presented from the aspect of formable shapes, while bonding models are shown from the aspect of calculation time, convergence, interface behavior of dissimilar materials as well as hot bonding status prediction. Two well-accepted numerical methodologies of bonding models, namely the contact algorithm and cohesive zone model (CZM) of bonding models and in simulations of the bonding process are highlighted. Particularly, recent advances and trends in the application of the combination of mechanical interlocking and metallurgical bonding, special energy fields, gradient structure, novel materials, green technology and soft computing method in the roll bonding process are also discussed. The challenges for advancing and prospects of the roll bonding process and bonding model are presented in an attempt to shed some light on the future research direction.
In-Band Network Telemetry in Industrial Wireless Sensor Networks (2019)

With the emergence of the Internet of Things (IoT) and Industry 4.0 concepts, industrial applications are going through a tremendous change that is imposing increasingly diverse and demanding network dynamics and requirements with a wider and more fine-grained scale. Therefore, there is a growing need for more flexible and reconfigurable industrial networking solutions complemented with powerful monitoring and management functionalities. In this sense, this paper presents a novel efficient network monitoring and telemetry solution for Industrial Wireless Sensor Networks mainly focusing on the 6TiSCH Network stack, a complete protocol stack for ultra-reliable ultra-low-power wireless mesh networks. The proposed monitoring solution creates a flexible and powerful in-band network telemetry design with minimized resource consumption and communication overhead while supporting a wide range of monitoring operations and strategies for dealing with various network scenarios and use cases. Besides, the technical capabilities and characteristics of the proposed solution are evaluated via a real-life implementation, practical and theoretical analysis. These experiments demonstrate that in-band telemetry can provide ultra-efficient network monitoring operations without any effect on the network behavior and performance, validating its suitability for Industrial Wireless Sensor Networks.
Supplementary Figure 1 from Identification of Polo-like Kinase 1 as a Potential Therapeutic Target in Anaplastic Thyroid Carcinoma (2023)

Supplementary Figure 1 from Identification of Polo-like Kinase 1 as a Potential Therapeutic Target in Anaplastic Thyroid Carcinoma
Ultrasound-Based Automated Carotid Lumen Diameter/Stenosis Measurement and its Validation System (2016)

Objective Degree of carotid stenosis is an important predictor to assess risk of stroke. Systolic velocity-based methods for lumen diameter and stenosis measurement are subjective. Image-based methods face a challenge because of low gradients in media and intima walls. Methods This article presents AtheroEdge™ 2.0, a two-stage process for automated carotid lumen diameter measurement that combats the above challenges. Stage one uses spectral analysis based on the hypothesis that far-wall adventitia is brightest. Stage two uses lumen pixel region identification based on the assumption that blood flow has constant density. Using global and local processing, lumen boundaries are detected. This clinical system outputs lumen diameter along with stenosis severity index (SSI). Results Our database consists of institutional review board–approved 202 patients (males/females: 155/47) left and right common carotid artery images (404 images, Toshiba scanner). Two trained neuro radiologists performed manual lumen border tracings using ImgTracer™ software. The coefficient of correlation between automated and two manual readings was 0.91 and 0.92. Dice similarity and Jaccard index were 95.82%, 95.72% and 92.10%, 91.92%, respectively. The mean diameter error between automated and two manual readings was 0.27 ± 0.26 and 0.26 ± 0.28 mm, respectively. Precision of merit was 98.05% and 99.03% with respect to two readings. SSI showed 97% accuracy. Conclusions The image-based automated carotid lumen diameter and stenosis measurement system is fast, accurate, and reliable.
<title>Finding the radiation spectrum of the waveguide gratings by physical optics and generalized transmission matrix approach</title> (1995)

Radiation form waveguide gratings are found via a bounded approach. The grating is enclosed by a metallic box to sample the continuous radiation spectrum. Then physical optics and generalized transmission matrix is used for analysis of grating.
Self-Assembly of Four-Layer Woodpile Structure from Zigzag ABC Copolymer/Aluminosilicate Concertinas (2008)

Scanning transmission electron tomography was used to determine the three-dimensional structure of a poly(ethylene-alt-propylene-block-ethylene oxide-block-n-hexyl methacrylate) (PEP-b-PEO-b-PHMA) triblock copolymer/aluminosilicate material with domain volume fractions of fPEP = 0.19, fPEO+aluminosilicate = 0.32, and fPHMA = 0.49. The PEO/aluminosilicate domains formed layers of zigzag-shaped strands (concertinas). Strands were arranged in a four-layer woodpile structure (Sozuer, H. S.; Dowling, J. P. J. Mod. Opt. 1994, 41, 231−239),1 in which strands in successive layers run in alternate directions (∼75°) and the third and fourth layers are offset. Modeling suggests the PEP and PHMA domains on the outside of each PEO/aluminosilicate strand may stabilize this unusual structure. This result suggests that synthetic macromolecules with multidomain architectures, such as ABC triblock copolymers, can direct the assembly of silica and other ceramic materials into complex new morphologies.
Autophagy in tumour suppression and promotion (2009)

Autophagy, a well-described cellular mechanism for lysosomal degradation of cytoplasmic content, has emerged as a tumour suppression pathway. Recent evidence indicates that the tumour suppressor function of autophagy is mediated by scavenging of damaged oxidative organelles, thereby preventing accumulation of toxic oxygen radicals that would cause genome instability. Paradoxically, however, in some cases autophagy can also promote the survival of cancer cells once tumours have developed. This is attributed to the ability of autophagy to promote cell survival under conditions of poor nutrient supply, as often faced by solid tumours and metastasising cancer cells. In addition, autophagy is frequently upregulated in tumours as a response to therapy and may protect tumours against therapy-induced apoptosis. In this review we discuss the mechanisms that link autophagy to tumour suppression and promotion and provide examples of the dual functions of autophagy in cancer.
Implementation of sequential circuit using feynman and fredkin reversible logic gates (2019)

Abstract At present, one of the most vital issue is reversible logic and this reversible logic has various applications in different areas such as low power CMOS, quantum computing, nanotechnology, cryptography, Digital Signal Processing(DSP), quantum dot cellular automata. A unique one-to-one mapping technique is used in reversible logic gates. To create a helpful capacity of gates, the reversible gates require some supported auxiliary data sources known as ancilla inputs. Likewise to keep up the reversibility of the circuits some extra unutilized yields are requiring that are referenced to as the trash yields. The quantity of garbage outputs, the quantity of ancilla sources of info and quantum cost assumes a noteworthy job in the reversible circuit’s assessment. Subsequently these parameters are most enormous for structuring reversible circuit’s effectively. In this paper implementing the sequential circuit using Feynman and Fredkin reversible logic gates. The proposed sequential circuit is simulated using Tanner Tool. The result shows that overhead delay and total delay are reduced by 33.69% and 20.42% respectively.
Towards an authentication middleware to support ubiquitous web access (2004)

This extended abstract reports our on-going work on the design and development of a flexible multifactor authentication middleware to support secure, finegrained and ubiquitous data access through Web services.
Transverse Elastic Buckling of Plane Pipe Gridworks (1974)

This note presents an approximate solution for predicting the buckling load factor for an orthogonal gridwork that is valid for arbitrary spacings and distribution of material and geometric properties. The Rayleigh-Ritz procedure is employed to reduce the problem to a solution of an eigenvalue problem. In addition, a procedure for combining computed Euler buckling load factors with semi-empirical buckling formulas for individual grid members is suggested.
Outpatient administration of naxitamab in combination with granulocyte‐macrophage colony‐stimulating factor in patients with refractory and/or relapsed high‐risk neuroblastoma: Management of adverse events (2022)

This article highlights the protocol-based recommendations for the management of acute AEs associated with outpatient naxitamab treatment in Trial 201. The authors recommend close monitoring and timely implementation of measures to ensure that patients can remain on treatment and obtain maximum clinical benefit from naxitamab therapy.
Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex (2003)

Radial glial cells and astrocytes function to support the construction and maintenance, respectively, of the cerebral cortex. However, the mechanisms that determine how radial glial cells are established, maintained, and transformed into astrocytes in the cerebral cortex are not well understood. Here, we show that neuregulin-1 (NRG-1) exerts a critical role in the establishment of radial glial cells. Radial glial cell generation is significantly impaired in NRG mutants, and this defect can be rescued by exogenous NRG-1. Down-regulation of expression and activity of erbB2, a member of the NRG-1 receptor complex, leads to the transformation of radial glial cells into astrocytes. Reintroduction of erbB2 transforms astrocytes into radial glia. The activated form of the Notch1 receptor, which promotes the radial glial phenotype, activates the erbB2 promoter in radial glial cells. These results suggest that developmental changes in NRG-1-erbB2 interactions modulate the establishment of radial glia and contribute to their appropriate transformation into astrocytes.
Abstract 17996: Treatment of Sleep-Disordered Breathing and Cardiac Remodeling in Heart Failure With Reduced Ejection Fraction: Insights From the CAT-HF Trial (2016)

Introduction: Sleep-disordered breathing (SDB) is a marker of poor prognosis in heart failure and may worsen cardiac dysfunction over time. Hypothesis: Adaptive servo-ventilation (ASV) treatment of...
Outcomes of Vascular Resection in Pancreaticoduodenectomy: Single-surgeon Experience (2013)

Extension of pancreatic adenocarcinoma into adjacent vasculature often necessitates resection of the portal vein (PV) and/or superior mesenteric vein (SMV) during pancreaticoduodenectomy (PD). The vein is reconstructed primarily by end-to-end anastomosis of vein remnants or venoplasty or by use of autologous or synthetic vein grafts. The objective of this study was to review outcomes in patients undergoing PD for pancreatic adenocarcinoma, specifically comparing the short- and long-term outcomes between the patients undergoing vascular resection and those undergoing standard PD. All patients undergoing PD for pancreatic adenocarcinoma by a single surgeon between 2007 and 2012 were reviewed. Of the 61 patients identified, 18 patients underwent vascular resection of the PV (four patients), SMV (10 patients), or both (four patients). The remaining 43 patients had standard PD. Demographic, perioperative, pathological, and long-term outcomes data were collected and both vascular and standard groups were compared. Both groups had similar demographics. The vascular group had significantly longer operative times (529 vs 406 minutes; P < 0.01) with a trend to greater estimated blood loss (0.64 vs 0.53 L; P = 0.06). Pathological analysis showed no difference between the two groups with regard to lymph node status/ratio and rate of R0 resection (94 vs 91%; P = 0.57); however, the size of the tumor was significantly greater in the vascular group (4.2 vs 3 cm; P < 0.01). Short-term outcomes were similar in the vascular group and standard group, respectively, with no difference in pancreatic fistula rate (6 vs 7%; P = 1.0), transfusion rate (44 vs 35%; P = 0.57), and median length of stay (8 vs 7 days; P = 0.10), and there was no 30-day mortality in either group. Based on Kaplan-Meier methods, the median recurrence-free survival was 18 versus 23 months (P = 0.37) in the vascular and standard groups, respectively, and the overall survival was almost identical in both groups, each with a median of 31 months (P = 0.91). In our experience, mesenteric and PV resection during PD was performed safely and without compromise of short- or longer-term outcomes. It can be performed safely and patients have no significant difference in perioperative outcomes or overall survival.
Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors. (1981)

Sepharose-bound anti-immunoglobulins, which are potent mitogens for normal adult B cells, are not mitogenic for tumor cells freshly isolated from mice carrying the B-cell leukemia BCL1. However, after 4 or more days of in vitro cultivation, BCL1 cells can be stimulated to divide by either anti-mu or anti-delta antibodies. These results suggest that in vitro cultivation of BCL1 cells results in their differentiation into more mature cells which can be triggered to proliferate by their interaction with anti-Ig antibodies. Addition of T-cell helper factors to anti-Ia treated BCL1 cells results in their differentiation into Ig-secreting cells. These results indicate that surface Ig molecules on BCL1 cells are capable of delivering an activation signal to the cells but that the cells require a second signal from T cells for induction of Ig secretion.
Use of a potent and selective highly constrained peptide agonist to design de novo an equally potent and selective non-peptide mimetic for the δ-Opioid receptor (2005)

A major but elusive goal of peptidomimetic research is the translation of 3D pharmacophore information of a potent bioactive peptide to a small non-peptide molecule with the same agonist biological activities. Successfully bridging the design gap from peptide to non-peptide mimetic requires, clarification of the geometrical relationships of key pharmacophores. First we undertook a detailed development of a 3D peptide pharmacophore based on design, synthesis and comprehensive evaluation of conformational and topographical space. We have used a potent and highly opioid receptor-selective analogue to successfully design, de novo, a high affinity, highly selective receptor ligand.
Creation of Stabilized Electrochromic Materials by Taking Advantage of Azulene Skeletons (2009)

Abstract The preparative scope of the new structural principle of utilization of azulene skeletons as redox‐active chromophores for the production of stabilized electrochromic materials is demonstrated in several examples. The structural principle takes advantage both of the cyanine‐type polymethine dyes and of the violene‐type redox systems. Appropriate combination of cyanine and/or violene substructures will produce at least one cyanine‐type structure in the reduced or oxidized form through an overall two‐electron transfer, although some will produce a cross‐conjugated cyanine‐type structure. Hünig's violene–cyanine hybrid structures, utilizing the bis(enediyne) system, afford electrochromic materials that exhibit strong absorptions in the near‐infrared region in the dianionic state. Cyanine–cyanine hybrid structures, consisting of pairs of cyanine units, show two‐step color changes based on single electron transfer in each step. Combinations of the cyanine and/or the violene substructures permit the design of novel stabilized electrochromic systems, including polyelectrochromic systems. The flexibility of the structural principle is demonstrated by the violene–violene hybrid, violene–cyanine–cyanine hybrid, violene‐cyanine‐violene hybrid, andviolene‐violene‐violene hybrid structures. New examples of the violene‐like redox system with inverse electron demand are provided by 6‐aminoazulene derivatives. The liquid‐crystalline properties of the redox‐active columnar mesogen are revealed by several azulene‐substituted electrochromic materials.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
The role of adipokines in the pathogenesis of gestational diabetes mellitus (2019)

Gestational diabetes mellitus (GDM) is a complex condition whose physiopathology to date has not been completely clarified. Two major metabolic disorders, insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. These elements are influenced by the amount of adipose tissue present before and/or during the pregnancy. Consequently, adipokines (adiponectin (APN), leptin (LPT), adipocyte fatty acid-binding protein, resistin, visfatin, omentin, vaspin, apelin, chemerin) secreted by adipose tissue, may contribute directly and/or indirectly, through the enhancement of chronic inflammation, aggravating insulin resistance and promoting GDM onset. This review aims to outline the potential physiopathological and prognostic role in GDM of adipokines, mainly APN and LPT.
NURBS interpolator with confined chord error and tangential and centripetal acceleration control (2010)

NURBS interpolation is highly requested in CNC systems because it allows high speed and high accuracy machining. In this work, an algorithm for NURBS interpolation capable of limiting chord error, centripetal acceleration and tangential acceleration is proposed. The algorithm is composed of two stages that may be executed simultaneously. In the first stage, the algorithm breaks down the curve into segments and, for each segment, calculates the feedrate limit that allows to respect both chord error tolerance and maximum centripetal acceleration limit. The second stage is a speed-controlled interpolator with a tangential acceleration limited feedrate profile generated using information provided by first stage. Software simulations are performed to verify the fulfillment of constraints and performance is compared to those of speed-controlled interpolator and variable feedrate interpolator.
Supplementary Figure 3 from A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2, as First-Line Monotherapy in Patients with Advanced Hepatocellular Cancer (2023)

&lt;p&gt;PDF file - 76K, Fold changes in biomarker levels relative to baseline following ramucirumab infusion across study cycles. Each line indicates values for a single patient.&lt;/p&gt;