gebhart/patrepeval huggingface dataset:
High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles (1996)

Previous studies have demonstrated that a high level of shear stress can produce platelet aggregation without the addition of any agonist. We investigated whether high shear stress could cause both platelet aggregation and shedding of microparticles from the platelet plasma membrane. A coneplate viscometer was used to apply shear stress and microparticle formation was measured by flow cytometry. It was found that microparticle formation increased as the duration of shear stress increased. Both microparticles and the remnant platelets showed the exposure of procoagulant activity on their surfaces. Investigation of the mechanisms involved in shear-dependent microparticle generation showed that binding of von Willebrand factor (vWF) to platelet glycoprotein lb, influx of extracellular calcium, and activation of platelet calpain were required to generate microparticles under high shear stress conditions. Activation of protein kinase C (PKC) promoted shear-dependent microparticle formation. Epinephrine did not influence microparticle formation, although it enhanced platelet aggregation by high shear stress. These findings suggest the possibility that local generation of microparticles in atherosclerotic arteries, the site that pathologically high shear stress could occur, may contribute to arterial thrombosis by providing and expanding a catalytic surface for the coagulation cascade.
Crystal structure of (E)-1-(1-bromo-2-naphthyl)-2-(3,5-dimethoxyphenyl)ethene (1993)

Abstract The title compound was prepared by Wittig-reaction of 1-bromo-2-formylnaphthalene and (3,5-dimethoxyphenyl)-methylene phosphorane. It crystallizes from dichloromethane/petroleum ether monoclinically in the space group P 2 1 / n with a = 1493.4(6), b = 842.3(2), c = 1485.0(6) pm and β = 117.95(3)°.
GigaPan Conversations: Diversity and Inclusion in the Community (2018)

GigaPan Conversations is jointly organized by the UNESCO International Bureau of Education (IBE) and Carnegie Mellon University (CMU) in collaboration with the UNESCO Associated Schools Project Network (ASPnet). The objective of this project is to promote empathy and understanding between cultures. Through inquiry-based and participatory practices in the curriculum, this project aims to promote dialogue and exchanges between school-age students on selected topics such as inclusion, Learning to Live Together, equity, cross-cultural inclusion and environment. This is with a view to foster a more in-depth approach to cultural and social issues, as well as enhanced inter-cultural understanding across different geographical regions and cultures. A major focus of the project is to use GigaPan technology and integrate it within a curricular framework to establish a robust Information and Communication Technology (ICT) in Education project capable of delivering tangible improvements in both classroom experience and learning results. This report details the motivation behind this work and initial experiences based on the first pilots conducted between Soweto township (South Africa) and Pittsburgh, Pennsylvania.
Immortalized sebocytes can spontaneously differentiate into a sebaceous‐like phenotype when cultured as a 3D epithelium (2012)

Sebocytes originate from the same lineage as keratinocytes, and both cell types may have similarities in terms of growth and differentiation. We were interested in studying the behaviour of human sebocytes when cultured in conditions validated for epidermal reconstruction. For this purpose, we established a HPV16-E6/7-immortalized human sebocyte cell line (SEBO662) growing in keratinocyte defined media. Postconfluent SEBO662 cells in monolayers express the early sebocyte marker, cytokeratin 7 (K7), do not express Epithelia Membrane Antigen (EMA) and do not exhibit strong lipogenic activity. However, when placed at the air-liquid interface, SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium. This work highlights the value of simple 3D models for exhibiting spontaneous differentiation and polarization.
Deexcitation of dipole emitters in finite ordered charge-sheet structures (2014)

Layered structures consisting of finite numbers of charge sheets separating dielectric layers are considered as physically realizable media for the control of dipole deexcitation due to spontaneous emission. The dispersion relation and the corresponding field distributions of a general structure are determined using transfer-matrix techniques. An excited dipole emitter localized in the vicinity of the truncation layer is coupled to the fields supported by such a structure, and its deexcitation rate is evaluated for a number of scenarios in which the structure is characterized by different numbers of charge sheets for varying excitation frequency and varying emitter position. The analysis highlights significant enhancements of the deexcitation rate which can be readily controlled through the adjustable parameters of the structure.
Metal‐Free Indeno[2,1‐b]thiophene‐Based Sensitizers for Dye‐Sensitized Solar Cells (2016)

Abstract A series of indeno[2,1‐ b ]thiophene‐containing organic dyes ( IDT1 – IDT5 ) have been synthesized, and their UV/Vis spectra extend beyond 700 nm. These dyes were employed as sensitizers for dye‐sensitized solar cells (DSSCs). Among them, dyes IDT3 – IDT5 with a thiophene unit conjugated with an anchor have better light harvesting ability and higher J SC values. Dye aggregation contributes substantially to the photocurrent in the near infrared region. The dye IDT5 , with chenodeoxycholic acid (CDCA) as the co‐adsorbent, has the highest power conversion efficiency (5.06 %) under AM 1.5G simulated sunlight irradiation, which is 68 % of the standard device based on N719 dye.
Adaptive terahertz absorber based on tunable graphene multilayer (2017)

A new adaptive terahertz absorbing screen providing a reflection coefficient lower than -10 dB in the frequency range 0.6-2.2 THz and with total thickness around 70 μm is proposed. The designed Salisbury screen, backed by a perfect electric conducting plate, consists of a first graphene layer as lossy sheet and two spacers made of polyethylene terephthalate (PET), separated by a tunable graphene/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laminate (GL). An electrostatic field up to 0.06 V/nm is applied across the GL in order to tune the electrical conductivity of the graphene layers, with the aim of minimizing the screen total reflection coefficient. A design procedure based on the transmission line method is proposed and a parameter sensitivity analysis of the reflection coefficient is carried out. The influence of the carrier charge mobility and of the number of graphene sheets composing the GL is investigated, considering different values of the electrostatic field in the frequency range 0.1-5 THz.
Turicella Otitidis as an Unusual Agent Causing a Posterior Auricular Abscess (2001)

A posterior auricular abscess in a 3-year-old girl was confirmed to have been caused by an unusual organism, Turicella otitidis.
Don't You Worry about That (2004)

A former premier of Queensland was in the habit of seeking to reassure Queenslanders, whenever he thought that reassurance was needed, with the words: 'Don't you worry about that'. Mr Bjelke-Petersen's mantle has now fallen on unlikely shoulders: those of Quadrant's tireless commentator- in-residence on bioethical and related social questions, Russell Blackford. Whatever novelty is proposed, Mr Blackford's response is always the same: there is nothing to worry about - and if anyone thinks there is, there must be something wrong with him.
A Study on the Characteristics of Excellent Lecturers in Medical School (2013)

We conclude that there are differences in the characteristics and competencies of excellent lecturers, as perceived by medical students and others. To increase the quality of teaching, it might be necessary to offer the opportunity to observe excellent lecturers, develop faculty development programs, and create educational culture.
Laser action in selected compounds containing C, N, and H or D (1967)

Laser action was found in electrical discharge containing carbon, nitrogen, and hydrogen or deuterium in their elemental forms. The wavelengths of oscillation observed were the same as those associated in the literature as resulting from transitions within rotation and vibrational states of the CN radical. Different wavelengths were observed when deuterium gas was substituted for hydrogen. No laser action was observed if neither hydrogen nor deuterium was present in the discharge, confirming that the active species is not the CN radical. Several organic compounds and combinations of organic and inorganic compounds were also tried. New lines were observed at 193.8, 198.8, 281, and 291 microns.
Templated Nanopores for Robust Functional Surface Porosity in Poly(methyl methacrylate) (2012)

A novel "sink and etch" technique is used to generate stable surface nanoporosity in poly(methyl methacrylate). Layer-by-layer assembly is first used to conformally coat PMMA substrates with a uniform layer of silica nanoparticles. Thermal annealing is then applied to cause sinking and engulfment of the silica nanoparticles into the thermoplastic PMMA surface. By selectively etching away the layer of embedded silica nanoparticles, a conformal porous layer of inversely templated structure can be obtained in the PMMA surface. Characterization with atomic force microscopy shows that a variety of nanoporous surface morphologies can be achieved simply by controlling the duration and temperature of thermal annealing. The nanoporous surfaces consisting of either as assembled silica nanoparticles or templated inverse porosity in PMMA were compared in terms of their antireflective (AR) properties. Measuring AR properties provided a quantitative means to compare the stability of these porous AR surfaces before and after several cleaning cycles. Our results show that while both types of surface porosity can provide excellent AR properties (optimized for 300-400 nm), the porous layer generated by the "sink and etch" technique showed superior mechanical stability.
IC‐O1‐05: Structural differences in cognitively normal elderly individuals with abnormal amyloid biomarkers: Detection using volumetric MRI in ADNI and AIBL (2012)

The ability to identify individuals in the pre-symptomatic stages of Alzheimer's disease is desirable for early diagnosis, intervention and counselling, as well as drug discovery. Pathological changes in the brain precede cognitive symptoms by several years, and disease-specific biomarkers could potentially detect pre-clinical disease. So far, most efforts at early detection have focused on individuals already suffering from mild cognitive impairment, or have required serial imaging over 12 months. Here, we use volumetric MRI to identify early signs of neurodegeneration in baseline images of cognitively normal elderly individuals with evidence of cortical β-amyloid deposition. Imaging and biological data are from 109 controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and 117 controls from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL). Baseline MRIs from both groups were automatically segmented into 83 anatomical regions. Regional volumes were normalised by intracranial volume. Participants were assigned to risk groups based on CSF Aβ1-42 in ADNI (high-risk ≤ 192pg/ml), and neocortical-to-cerebellar ratios of amyloid deposition on [11C]PiB-PET imaging in AIBL (high-risk >1.5). Normalised regional MR volumes were compared between the high- and low-risk sub-sets. Among ADNI participants, 39% were classified as high-risk. Fourteen of 83 regions across the brain were significantly smaller in the high-risk group (P <0.05). This study shows volumetric differences—at baseline—in cognitively normal individuals differing in amyloid-based risk status for the development of Alzheimer's disease. The consistency of regional differences observed in two independent groups suggests that volumetric MRI can reveal structural brain changes that precede the onset of clinical symptoms. It may therefore be useful in identifying early signs of neurodegeneration in healthy elderly individuals, potentially providing a useful early screening tool, or outcome measure for clinical trials. Regional t-values on maximum probability brain atlas significant regions (P <0.05, uncorrected) outlined
Enhancing covalent mechanochemistry in bulk polymers using electrospun ABA triblock copolymers (2014)

The mechanochemical activation of covalent bonds in bulk polymers is often characterized by low conversions. Here we report that the activation of gem-dibromocyclopropane (gDBC) mechanophores embedded in a poly(1,4-butadiene) (PB) is enhanced when a central gDBC-PB block is flanked by two polystyrene (PS) end blocks in an ABA-type triblock architecture. Electrospinning the PS-(gDBC)PB-PS leads to even greater activation in aligned fiber mats under tension.
Evaluation of FRP gluing on concrete structures by active infrared thermography (2010)

The strengthening or retrofitting of reinforced concrete structures by externally bonded Fiber Reinforced Polymer systems is now a commonly accepted and widespread technique.Durability of such repairing technique leans by part on the good quality of the gluing of FRP on site.Among the Non-Destructive Evaluation (NDE) techniques under investigation for bonding quality assessment, active infrared thermography is of particular interest given its relatively easiness of deployment and rapidity to inspect large surfaces for which only one side is accessible.In this paper, numerical simulation and experiments were performed and pulse heating and square heating excitations were investigated.A first set of tests with the pulsed phase thermography algorithm were carried out for defect depth retrieval.
Identification of diverse BoLA DQA3 genes consistent with non‐allelic sequences (1998)

Genetic diversity within the DQA genes of the major histocompatibility complex (Mhc) of cattle is characterised by multiple polymorphic loci that can vary in number between haplotypes. Previous analysis of the second exon sequences derived from genomic BoLA DQA3 genes identified two distinct families, DQA3*01 and DQA3*02. In this report, we describe the nucleotide and predicted amino acid sequences of the entire coding region of three transcribed BoLA DQA3 genes representing each of these families. These data provide additional evidence that the BoLA DQA3 locus is distinct from BoLA DQA1 and BoLA DQA2. In addition, the amino acid sequence of DQA3 genes from the two families is shown to differ by 35 out of the 254 amino acids. Putative locus-specific amino acid sequence motifs within the transmembrane and intracytoplasmic domains of DQA genes are shown to differ between the DQA3*01 and DQA3*02 genes. Phylogenetic analysis reveals a genetic distance that is considerably larger than that seen between orthologous Mhc allelic families. These data are consistent with either an extremely divergent family of DQA3 genes or an allele at an additional BoLA DQA4 locus.
A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases (2018)

Despite the success of current biological therapeutics for rheumatoid arthritis, these therapies, targeting individual cytokines or pathways, produce beneficial responses in only about half of patients. Therefore, better therapeutics are needed. IL-6 and IL-17A are proinflammatory cytokines in many autoimmune and inflammatory diseases, and several therapeutics have been developed to specifically inhibit them. However, targeting both of these cytokines with a bispecific therapeutic agent could account for their nonoverlapping proinflammatory functions and for the fact that IL-6 and IL-17A act in a positive feedback loop. Here, we present the development of MT-6194, a bispecific antibody targeting both IL-6R and IL-17A that was developed with the FynomAb technology. We also present data from mouse inflammatory disease experiments, indicating that simultaneous inhibition of both IL-6 and IL-17A yields enhanced efficacy compared with inhibition of each cytokine alone.
An Informal Management Model for Diffserv Routers (2002)

This document proposes an informal management model of Differentiated Services (Diffserv) routers for use in their management and configuration. This model defines functional datapath elements (e.g., classifiers, meters, actions, marking, absolute dropping, counting, multiplexing), algorithmic droppers, queues and schedulers. It describes possible configuration parameters for these elements and how they might be interconnected to realize the range of traffic conditioning and per-hop behavior (PHB) functionalities described in the Diffserv Architecture.
Down's syndrome: A modern otorhinolaryngological perspective (1981)

Abstract The incidence of Down's syndrome is estimated at 1.5 per 1000 births, or 7,000 newborns annually in this country. Mounting financial considerations in the delivery of medical care, as well as humanitarian considerations, fostered this in‐depth prospective, multidisciplinary study. One hundred and seven patients comprised the initial group, and 83 met the criteria established for documentation of otorhinolaryngological parameters. All patients were home based and given scheduled, routine pediatric care. Otolaryngology care, when indicated, was by consultation. The uniqueness of this study exists in the fact that children were followed from the first year of life, in what must be considered an enhanced environmental setting for Down's syndrome patients. Otologic, rhinologic and laryngologic parameters were explored in‐depth with the following resultant data. Patients with stenotic ear canals had a markedly increased incidence of associated middle ear effusion. In addition, patients with an increased frequency of upper respiratory tract infections in association with stenotic canals had an even greater incidence of effusion. When stenotic canals were present, the diagnosis of fluid proved difficult for the primary care physician. The total incidence of conductive middle ear pathology was shown to be significantly lower than in most reported studies. Equally important was the fact that at the time of data computation, none of the children had active, chronic middle ear pathology and cholesteatoma had not been identified. Adenoidectomy was shown clinically to have little apparent effect on the course of otologic pathology, nasal respiration or rhinorrhea in Down's syndrome. Previously unreported surgical correlates of the nasopharyngeal anatomy were related to upper respiratory obstructive symptoms manifest by many of these children. Apparent, spontaneous resolution of the latter, in most instances with age, correlated well with anticipated changes in the growth of the involved structures. Low dose antibiotic therapy was shown to be of benefit in controlling early rhinorrhea. Isolated congenital abnormalities of the lower respiratory tract were discussed with the findings that symptoms related to the respiratory tract must not be assumed to be inherent to the syndrome until other potential etiologies have been thoroughly considered. Factors relating to intelligence in Down's syndrome were explored with the conclusion that a direct and favorable comparison could be made in this study between improved hearing and improved intellect.
Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors (2006)

By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp.
The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer (2011)

Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles of immunoproteasome subunits have not been recognized so far. We analyzed the genetic polymorphism of the immunoproteasome subunits LMP2 and LMP7 and of the transporters associated with antigen processing (TAP1 and TAP2) in two independently collected panels of colorectal carcinoma patients (N(1) = 112, N(2) = 62; controls, N = 165). High risk of colon cancer was associated with the LMP7-K/Q genotype (OR = 8.10, P = 1.10 × 10(-11)) and low risk with the LMP7-Q/Q genotype (OR = 0.10, P = 5.97 × 10(-13)). The basis for these distinct associations of LMP7 genotypes was functionally assessed by IFN-γ stimulation of colon carcinoma cell lines (N = 10), followed by analyses of mRNA expression of HLA class I, TAP1, TAP2, and LMP7, with real-time PCR. Whereas induction of HLA-B, TAP1, and TAP2 was comparable in all cell lines, transcript amounts of LMP7-Q increased 10-fold, but of LMP7-K only 3.8-fold. This correlated with a reduced transcript stability of LMP7-K (t(1/2) ≈ 7 minutes) compared with LMP7-Q (t(1/2) ≈ 33 minutes). In addition, LMP7-Q/Q colon carcinoma cells increased (the peptide based) HLA class I surface expression significantly after IFN-γ stimulation, whereas LMP7-Q/K and LMP7-K/K carcinoma cells showed minimal (<20%) changes. These results suggest that the presence of LMP7-K can reduce the formation of immunoproteasomes and thus peptide processing, followed by reduced peptide-HLA presentation, a crucial factor in the immune response against cancer.
HP1γ function is required for male germ cell survival and spermatogenesis (2010)

The Cbx3 gene product (the HP1gamma protein) has a non-redundant function during spermatogenesis that cannot be compensated for by the other two HP1 isotypes. The Cbx3hypo/hypo spermatogenesis defect is similar to that found in Miwi2 and Dnmt3L mutants. The Cbx3 gene-targeted mice generated in this study provide an appropriate model for the study of HP1gamma in transposon silencing and parental imprinting.
i-SRAM: Interleaved Wordlines for Vector Boolean Operations Using SRAMs (2020)

The generic approach toward SRAM based in-memory computations has been to activate multiple memory rows simultaneously and read out a logic function of the constituent rows. In general, these schemes introduce errors in computations due to their analog nature, limiting their usage to error-resilient applications such as machine learning. In contrast, in-memory bulk bit-wise Boolean computations are suitable not only for error-resilient applications, but also those that require accurate computations like encryption. Prior works have indeed accomplished such bit-wise computations, however, they require modifications to the normal SRAM read operations leading to degraded read-stability or lower sense-margin. In this paper, we propose interleaving the word-lines (i-SRAM) as the basic approach for embedding bit-wise computations in SRAM arrays. Further, our i-SRAM read operation is identical to the normal memory read operation without loss of read-robustness or sense-margin. Even at deeply scaled nodes, as long as normal SRAM read stability is ascertained, the presented proposal works equally well. As opposed to prior works, this is a key benefactor in allowing the proposal to be seamlessly integrated in state-of-the-art SRAM compilers. We propose different configurations of i-SRAM for 6T and 8T-bit-cells, with minimal area overhead. We further demonstrate upto $\sim 2 \times $ improvement in energy and $\sim 8 \times $ improvement in throughput for a binary neural network (BNN) and $\sim 3.5 \times $ improvement in energy and $\sim 3 \times $ improvement in throughput for AES encryption using the proposed i-SRAM in a modified von-Neuamnn machine.