gebhart/patrepeval huggingface dataset:
Bipolar Copolymers as Host for Electroluminescent Devices:  Effects of Molecular Structure on Film Morphology and Device Performance (2007)

Bipolar transport polymers have been developed as host materials for electroluminescent devices by incorporating both electron-transporting and hole-transporting functionalities into copolymers. Two different copolymers having the same molecular weight (Mn ∼ 30 kg/mol) and the same fraction of electron-transporting monomers (fOXA = 0.50) have been synthesized in the form of random and diblock copolymers, respectively. The effect of molecular structure and film morphology of these bipolar polymers on device performance has been studied. For the diblock copolymers, pronounced phase segregation forming different nanomorphologies has been observed by modern microscopic techniques, which is not observed for the random counterparts under the same thin film preparation conditions. The results of single-layer polymer light emitting diodes (PLEDs) show that the nanophase separation morphology of diblock copolymers has a significant effect on device performance: lowering charge transport and facilitating the hole−electron recombination leads to a much higher quantum efficiency. Applying this high triplet block copolymer as host, a high external quantum efficiency of 5.4% at the brightness of 900 cd/m2 was achieved for single-layer PLEDs with a green-emitting complex dopant.
EP018/#324 The efficacy and molecular mechanisms of MDR-reversal agents (stony brook taxanes) in resistant ovarian carcinoma models (2022)

<h3>Objectives</h3> Taxane resistance is a serious problem in the successful treatment of ovarian carcinoma. New generations of taxane analogs (Stony Brook taxanes; SB-Ts) seem to be effective against resistant solid tumors. Our aim was to estimate in vitro and in vivo efficacy of SB-Ts in comparison to paclitaxel and discover underlying changes of gene expression profile connected with the treatment of taxanes. <h3>Methods</h3> NCI/ADR-RES and SKOV-3/PCT-RES human ovarian cancer cell lines were used as multidrug-resistant model. The efficacy of taxanes was compared via assessment of IC<sub>50</sub> values. Flow cytometry was used for analysis of cell cycle changes. In vivo efficacy of taxanes was measured after intraperitoneal application of paclitaxel alone (10 mg/kg) or combined with SB-Ts (1–5 mg/kg) twice a week in resistant ovarian cell line-derived xenograft (CDX) models. Gene expression profiles were followed by quantitative real-time PCR in CDX tumors. <h3>Results</h3> In vitro experiments revealed the third generation SB-Ts – SB-T-121605 and SB-T-121606 as the most effective. In vivo, both SB-Ts effectively suppressed tumor growth at low doses (&lt;3 mg/kg) in combination with paclitaxel, limiting their adverse effects. Treatment of SB-Ts also led to significant deregulation of many genes involved in resistance. <h3>Conclusions</h3> SB-T-121605 and SB-T-121606 are promising candidates for further studies, aimed at development of novel therapeutics for therapy of resistant ovarian tumors. Supported by projects of the Czech Science Foundation no. 21–14082S, the Czech Ministry of Education, Youth and Sports: INTER-ACTION, project no. LTAUSA19032, and the National Institutes of Health (NIH), U.S.A. grant R01 CA103314.
The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial (2016)

The use of L-PRF as a socket filling material to achieve preservation of horizontal and vertical ridge dimension at three months after tooth extraction is beneficial.
Epinephrine-Induced Arrhythmias during Halothane Anesthesia with the Addition of Nitrous Oxide, Nitrogen, or Helium in Dogs (1982)

The arrhythmogenicity of epinephrine was examined in 34 male mongrel dogs awake and during 1.1 MAC steady state halothane-O2 anesthesia with the addition of 50% N2O, nitrogen, or helium. All anesthetized dogs required more epinephrine than did awake dogs to produce ventricular extrasystoles. Dogs given halothane-N2O were more sensitive to the epinephrine infusion than those given halothane-nitrogen or halothane-helium. The dogs given halothane-N2O also showed a small, but statistically significant difference from dogs given halothane-O2. These results suggest that the addition of N2O to halothane increases the cardiac arrhythmic potential of epinephrine in the dog.
Mode of Action of a Purified Antitumor Protein from the Proteinaceous Crystal of Bacillus thuringiensis subsp. thuringiensis on Yoshida Ascites Sarcoma Cells (1976)

A purified antitumor protein from the proteinaceous crystal of Bacillus thuringiensis subsp. thuringiensis inhibits the growth of Yoshida ascites sarcoma both in vivo and in vitro. Exogenous respiration of the tumor cells was unaffected by the protein at a concentration as high as 500 mug/ml. The antitumor protein inhibits the uptake and incorporation of labeled precursors into macromolecules. However, the ratio of incorporation over uptake is not affected by the protein. Further, the protein brings about the leakage of 260-nm-absorbing material, proteins, and (32)P-labeled cellular constituents from the Yoshida ascites sarcoma cells. The results show that the action of the antitumor protein appears to alter the cellular permeability of the tumor cells.
Bladder, bowel, and sexualdysfunction (2014)

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Security assertion exchange for the agent on the semantic web (2004)

The Semantic Web's success will depend on the implementation and use of Web Service becoming preeminent in E-commerce, which will likely be agent-based in the future. On the Semantic Web, the agent can use the large amount of information available over the web, but this capability of the agent will allow it more subtle attacks. As the agent plays more mission critical roles within Web Service, the agent and supporting technologies need to be secure and reliable. Additionally, the agent has charge of different and various roles on the heterogeneous platforms over the Semantic Web. As a result of this, its requirement and qualification for access to information are dynamically changed according to the case. In order to make the agent secure and to support its work, in this paper we will discuss the requirements for agent security on the Semantic Web and propose a method that the agent dynamically exchanges its authentication and authorization information using SAML. Finally, we will conclude our talks by summarizing our proposal and presenting further works.
Motion control of spherical robot based on conservation of angular momentum (2009)

Spherical robot is a special type of mobile robot which spherical structure offers special characteristic of motion, for example it has the capability to recover from collisions with static or mobile obstacles in the same area. In this paper the motion control of a kind of spherical robot based on conservation of angular momentum is discussed. Firstly, the dynamic model of a simplified version of this kind of spherical robot is built and analyzed with Lagrange equation, and its differential motion equation is obtained and the relation equation between the motion of the spherical robot and the motion of the rotor is deduced. Then, how to control the motion of internal rotor to realize expected motion of this kind of spherical robot is presented. Finally, with the parameters of a prototype of a spherical robot the motion control approach is verified by simulations with Matlab and ADAMS respectively.
Online multispectral fluorescence lifetime values estimation and overlay onto tissue white-light video frames (2016)

Fluorescence lifetime imaging has been shown to be a robust technique for biochemical and functional characterization of tissues and to present great potential for intraoperative tissue diagnosis and guidance of surgical procedures. We report a technique for real-time mapping of fluorescence parameters (i.e. lifetime values) onto the location from where the fluorescence measurements were taken. This is achieved by merging a 450 nm aiming beam generated by a diode laser with the excitation light in a single delivery/collection fiber and by continuously imaging the region of interest with a color CMOS camera. The interrogated locations are then extracted from the acquired frames via color-based segmentation of the aiming beam. Assuming a Gaussian profile of the imaged aiming beam, the segmentation results are fitted to ellipses that are dynamically scaled at the full width of three automatically estimated thresholds (50%, 75%, 90%) of the Gaussian distribution's maximum value. This enables the dynamic augmentation of the white-light video frames with the corresponding fluorescence decay parameters. A fluorescence phantom and fresh tissue samples were used to evaluate this method with motorized and hand-held scanning measurements. At 640x512 pixels resolution the area of interest augmented with fluorescence decay parameters can be imaged at an average 34 frames per second. The developed method has the potential to become a valuable tool for real-time display of optical spectroscopy data during continuous scanning applications that subsequently can be used for tissue characterization and diagnosis.
Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learning (2022)

Epidemiological studies show that COVID-19 variants-of-concern, like Delta and Omicron, pose different risks for severe disease, but they typically lack sequence-level information for the virus. Studies which do obtain viral genome sequences are generally limited in time, location, and population scope. Retrospective meta-analyses require time-consuming data extraction from heterogeneous formats and are limited to publicly available reports. Fortuitously, a subset of GISAID, the global SARS-CoV-2 sequence repository, includes “patient status” metadata that can indicate whether a sequence record is associated with mild or severe disease. While GISAID lacks data on comorbidities relevant to severity, such as obesity and chronic disease, it does include metadata for age and sex to use as additional attributes in modeling. With these caveats, previous efforts have demonstrated that genotype-patient status models can be fit to GISAID data, particularly when country-of-origin is used as an additional feature. But are these models robust and biologically meaningful? This paper shows that, in fact, temporal and geographic biases in sequences submitted to GISAID, as well as the evolving pandemic response, particularly reduction in severe disease due to vaccination, create complex issues for model development and interpretation. This paper poses a potential solution: efficient mixed effects machine learning using GPBoost, treating country as a random effect group. Training and validation using temporally split GISAID data and emerging Omicron variants demonstrates that GPBoost models are more predictive of the impact of spike protein mutations on patient outcomes than fixed effect XGBoost, LightGBM, random forests, and elastic net logistic regression models.
Design, Development, and Performance of a Turbine Research Facility to Study Rotor Stator Interaction Effects (1996)

Article Design, Development, and Performance of a Turbine Research Facility to Study Rotor Stator Interaction Effects was published on September 1, 1996 in the journal International Journal of Turbo & Jet-Engines (volume 13, issue 3).
10. The Renewal Theorem and Local Limit Theorem (1992)

1. INTRODUCTION
Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells (2008)

Dendritic cells in the kidney take up antigens, but little is known about their role in providing co-stimulatory signals for the activation of CD4(+) cells. This study examined the phenotype of dendritic cells in the renal interstitium and in the lymph node draining the kidney before and after intrarenal ovalbumin injection. After intrarenal injection of the antigen, expression of the co-stimulatory molecules CD86 and programmed cell death ligand 1 (PD-L1) increased on renal dendritic cells, whereas expression of only CD86 increased on dendritic cells of the draining lymph node. The activation and proliferation of antigen-specific CD4(+) cells in the lymph node were assessed by transfer of naïve, fluorescently labeled ovalbumin-specific T cell receptor transgenic cells to mice before antigen administration. Blocking both CD86 and CD80 profoundly inhibited CD4(+) cell proliferation, but CD86 was the dominant CD28 ligand in the early proliferative response of CD4(+) cells. Conversely, activation of PD-1, the receptor expressed on CD4(+) cells that binds PD-L1 and PD-L2, reduced the proliferation of CD4(+) cells in the draining lymph node. Comparing subcutaneous and intrarenal administration of antigen, it was found that CD4(+) cell activation was slower and the effects of combined CD80 and CD86 blockade were more profound when antigen was presented via the kidney compared with the skin. In summary, renal dendritic cells take up antigen and participate in the control of antigen-specific CD4(+) cell proliferation by upregulating co-stimulatory molecules such as CD86 that stimulate CD4(+) cell proliferation and by signaling through PD-1, which prevents an inappropriately exuberant immune response.
Preparation of ZSM‐5 Coated on Monolithic Interconnected Macroporous Al2O3 Using Cheap n‐Butylamine as Template (2015)

Abstract Using cheap n ‐butylamine as template, ZSM‐5 zeolites have been successfully synthesized and coated on monolithic interconnected macroporous Al 2 O 3 by the secondary growth method. The use of cheap n ‐butylamine could significantly reduce the synthesis cost. Hierarchical monolithic ZSM‐5 zeolites were prepared from synthetic mixtures with different H 2 O/Na 2 O or SiO 2 /Al 2 O 3 ratio. The synthesized samples were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR) and N 2 adsorption‐desorption. The results show that the hierarchical monolithic zeolites were obtained with cheap n ‐butylamine template as template. During the hydrothermal reaction process, the morphology of the micrometer‐sized support was well maintained. The irregular crystals were formed in a wide range of the H 2 O/Na 2 O or SiO 2 /Al 2 O 3 ratio of synthetic mixtures and coated on monolithic Al 2 O 3 . The relative crystallinity of the zeolites was highest at H 2 O/Na 2 O=250 or SiO 2 /Al 2 O 3 =160. This type of composites exhibited hierarchical porous structures and relatively high specific surface areas.
Rigorous losses evaluation in the numerical analysis of SIW structures (2015)

International audience
Molecular imaging of Escherichia coli F0F1‐ATPase in reconstituted membranes using atomic force microscopy (1996)

The structure of Escherichia coli F0F1-ATPase (ATP synthase), and its F0 sector reconstituted in lipid membranes was analyzed using atomic force microscopy (AFM) by tapping-mode operation. The majority of F0F1-ATPases were visualized as spheres with a calculated diameter of approximately 90 angstroms, and a height of approximately 100 angstroms from the membrane surface. F0 sectors were visualized as two different ring-like structures (one with a central mass and the other with a central hollow of greater than or equal to 18 angstroms depth) with a calculated outer diameter of approximately 130 angstroms. The two different images possibly represent the opposite orientations of the complex in the membranes. The ring-like projections of both images suggest inherently asymmetric assemblies of the subunits in the F0 sector. Considering the stoichiometry of F0 subunits, the area of the image observed is large enough to accommodate all three F0 subunits in an asymmetric manner.
Real-time detection of intrusive traffic in QoS network domains (2013)

A capable, scalable, and reliable model detects intrusive traffic by investigating the impact of user behavior on quality-of-service regulations in real time. The model also proposes reliable coordination for investigating user traffic, including traffic injected through several gateways. Traffic investigation is triggered only when the network is congested; at that moment, burst gateways generate an echo of explicit congestion notification to misbehaving users. The model investigates these users by measuring their bandwidth consumption ratios. User traffic that exceeds the service-level agreement bandwidth ratio is filtered as intrusive. Simulation results demonstrate that the proposed model efficiently monitors user behavior and detects intrusive traffic.
AUTOMATIC CORN PLANT POPULATION MEASUREMENT USING MACHINE VISION (2003)

A machine visionbased corn plant population sensing system was developed to measure early growth stage cornpopulation. Video was acquired from a vehiclemounted digital video camera at V3 to V4 stages under different daylightconditions. Algorithms were developed to sequence video frames and to segment, singulate, and count corn plants. Vegetationsegmentation was accomplished using a truncated ellipsoidal decision surface. Two features were extracted from each pixelrow of the segmented images: total number of plant pixels, and their median position. Adjacent rows of the same class weregrouped together and iteratively refined for final plant counting. Performance of this system was evaluated by comparingits estimation of plant counts with manual stand counts in 60 experimental units of 6.1 m sections of corn rows. The numberof corn plants in these experimental units ranged from 14 to 48, corresponding to a population of 30,000 to 103,000 plants/ha. In lowweed field conditions, the system plant count was well correlated to manual stand count (R2 = 0.90). Standarderror of population estimate was 1.8 plants over 33.2 mean manual plant count, or 5.4% coefficient of variation.
The road to OLFAR - a roadmap to interferometric long-wavelength radio astronomy using miniaturized distributed space systems (2013)

The Orbiting Low Frequency Antennas for Radio Astronomy (OLFAR) project aims to develop a space-based low frequency radio telescope that will explore the universe's so-called dark ages, map the interstellar medium, and discover planetary and solar bursts in other solar systems. The telescope, composed of a swarm of at least fifty satellites working as a single instrument, will be sent to a location far from Earth in order to avoid the high Radio Frequency Interference (RFI) found at frequencies below 30 MHz, originating from Earth. The OLFAR telescope is a novel and complex system, requiring not-yet proven technologies and systems, therefore, a number of key technologies are still to be developed and proven. Most of these can be tested on Earth, but four aspects in particular require in-space verification. Those are (1) the satellite's propulsion and attitude control systems, and (2) their interactions with the large science antennas, as well as the (3) payload system itself and finally (4) the in-space interferometry and 3D-imaging. Furthermore, the RFI environment in the intended target orbits is mostly unknown. Indeed, only three satellites missions have previously been launched into orbit shedding light on the RFI environment, but sufficiently detailed measurements allowing for the creation of a usable RFI model have never been performed. To carry out both the hardware qualification and RFI measurements, a few pathfinder missions are deemed in order. This paper describes these pathfinders in detail; outlining the scientific objective, the technologies being demonstrated as well as the missions' roadmap which revolves around a novel systems engineering approach. This approach resembles those used in certain fast-paced industries where development is heavily parallelised and products are launched as soon as opportunities arise. This will be combined with in-space upgrading of mission firmware to allow for high flexibility within the limited time and budget constraints of these pathfinders.
Investigation into the effect of culture conditions on embryo viability and invasive and non-invasive markers of embryo selection (2014)

The objectives of this study were to compare different culture conditions and methods used to assess preimplantation embryos. Both invasive and non-invasive markers including the blastocyst formation rate, DNA damage and aneuploidy were investigated. The first aim was to study the relationship between the metabolic profile and embryo development, morphology and aneuploidy in human embryos. The amino acid profile of 15 frozen-thawed human embryos was analysed by HPLC and the turnover of certain amino acid was significantly correlated to their developmental potential. However no relation was found between embryo morphology and its amino acid profile. The second aim was to compare murine in vitro cultured blastocysts to in vivo developed blastocysts for aneuploidy and DNA fragmentation. Two-cell stage embryos were cultured in vitro until the blastocyst stage. In vivo embryos were obtained on day 2 and day 5 following superovulation without further in vitro culture. DNA fragmentation and mosaicism increased with embryo development with higher rates for in vitro developed blastocysts compared to in vivo. The third aim was to evaluate the use of the morphokinetic parameters of EmbryoScope™ as predictors of embryo development, DNA fragmentation, aneuploidy and to assesses the effect of GM-CSF. Two-cell stage embryos were cultured until the blastocyst stage in the Embryoscope™ with and without GM-CSF. No progress in the growth rate of the GM-CSF cultured embryos was recorded. The detailed analysis of the lengths of early cleavages was informative in defining developmental potential but with no relationship with the rate of mosaicism and DNA fragmentation. The relationship between embryo viability, development, DNA fragmentation and chromosomal status is clearly complex as embryos with good morphology may reach the blastocyst stage but be chromosomally abnormal or with high DNA fragmentation. Embryo selection should be established on more than one criterion permitting the selection and transfer of one embryo with the highest implantation potential.
A ring-like accretion structure in M87 connecting its black hole and jet (2023)

The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation<sup>1,2</sup>. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole<sup>3</sup>. Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of [Formula: see text] Schwarzschild radii in diameter, approximately 50% larger than that seen at 1.3 mm. The outer edge at 3.5 mm is also larger than that at 1.3 mm. This larger and thicker ring indicates a substantial contribution from the accretion flow with absorption effects, in addition to the gravitationally lensed ring-like emission. The images show that the edge-brightened jet connects to the accretion flow of the black hole. Close to the black hole, the emission profile of the jet-launching region is wider than the expected profile of a black-hole-driven jet, suggesting the possible presence of a wind associated with the accretion flow.