gebhart/patrepeval huggingface dataset:
Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor (1982)

A growth hormone releasing factor of a human pancreatic islet tumor (hpGRF) of an acromegalic patient was purified and subjected to Edman degradation in a spinning cup sequencer. Approximately 0.7-1.2 nmol of peptide was applied to the cup without any pretreatment, after coupling to 3-sulfophenyl isothiocyanate or after cleavage with cyanogen bromide, staphylococcal protease, or trypsin. On the basis of the analytical data, the N-terminal sequence of 39 residues is established to be H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn- Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys- Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser- Asn-Gln-Glu-Arg-Gly-. It is proposed that alanine is residue 40 and represents (as free acid) the C terminus of hpGRF. Synthetic hpGRF(1-40)-OH is highly potent in stimulating GH secretion from the rat anterior pituitary in vitro and in vivo. The C-terminal sequence of hpGRF does not appear to contribute significantly to the biologic intrinsic activity and potency of hpGRF, as demonstrated by the fact that the natural product and the synthetic peptides hpGRF(1-40)-OH, hpGRF(1-40)-NH2, and hpGRF(1-29)-NH2 show equivalent in vitro activities. On the basis of sequence homologies, hpGRF is closely related to members of the glucagon secretin family, especially to the porcine gut peptide PHI.
Serologic Detection of Human Papillomavirus-Related Anogenital Disease: New Opportunities and Challenges (1995)

Journal Article Serologic Detection of Human Papillomavirus-Related Anogenital Disease: New Opportunities and Challenges Get access Joel M. Palefsky Joel M. Palefsky Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 6, 15 March 1995, Pages 401–402, https://doi.org/10.1093/jnci/87.6.401 Published: 15 March 1995 Article history Received: 08 February 1995 Accepted: 09 February 1995 Published: 15 March 1995
Using category-based collaborative filtering in the Active WebMuseum (2002)

Collaborative filtering is an important technology for creating user-adapting Web sites. In general the efforts of improving filtering algorithms and using the predictions for the presentation of filtered objects are decoupled. Therefore, common measures (or metrics) for evaluating collaborative filtering (recommender) systems focus mainly on the prediction algorithm. It is hard to relate the classic measurements to actual user satisfaction because of the way the user interacts with the recommendations, determined by their representation, influences the benefits for the user. We propose an abstract access paradigm, which can be applied to the design of filtering systems, and at the same time formalizes the access to filtering results via multi-corridors (based on content-based categories). This leads to new measures which better relate to the user satisfaction. We use these measures to evaluate the use of various kinds of multi-corridors for our prototype user-adapting Web site, the Active WebMuseum.
Measurement of the Ratio of Branching FractionsB(B¯0→D*+τ−ν¯τ)/B(B¯0→D*+μ−ν¯μ) (2015)

The branching fraction ratio R(D^{*})≡B(B[over ¯]^{0}→D^{*+}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]^{0}→D^{*+}μ^{-}ν[over ¯]_{μ}) is measured using a sample of proton-proton collision data corresponding to 3.0 fb^{-1} of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode τ^{-}→μ^{-}ν[over ¯]_{μ}ν_{τ}. The semitauonic decay is sensitive to contributions from non-standard-model particles that preferentially couple to the third generation of fermions, in particular, Higgs-like charged scalars. A multidimensional fit to kinematic distributions of the candidate B[over ¯]^{0} decays gives R(D^{*})=0.336±0.027(stat)±0.030(syst). This result, which is the first measurement of this quantity at a hadron collider, is 2.1 standard deviations larger than the value expected from lepton universality in the standard model.
Innate immune recognition and control of adaptive immune responses (1998)

The immune system of higher vertebrates consists of two components: innate and adaptive. The innate immune system relies on a set of germ-line encoded receptors that recognize conserved molecular patterns found only in microorganisms. The adaptive immune system uses somatically generated antigen receptors which are clonally distributed on the two types of lymphocytes: T cells and B cells. These antigen receptors are generated by random processes and, as a consequence, the general design of the adaptive immune system is based on clonal selection of lymphocytes expressing receptors with particular specificities. Here we discuss the essential role of the innate immune system in the clonal selection of lymphocytes and activation of the adaptive immune responses.
ChemInform Abstract: Hippuristerone A, a Novel Polyoxygenated Steroid from the Gorgonian Isis hippuris. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Current, charge, and capacitance during scanning probe oxidation of silicon. II. Electrostatic and meniscus forces acting on cantilever bending (2004)

A comprehensive analysis of the electrical current passing through the tip-substrate junction during oxidation of silicon by scanning probe microscopy (SPM) is presented. This analysis identifies the electronic and ionic contributions to the total current, especially at the initial stages of the reaction, determines the effective contact area of the tip-substrate junction, and unifies the roles of space charge and meniscus formation. In this work, we concentrate on noncontact SPM oxidation. We analyze simultaneous force-distance and current-distance curves to demonstrate that total current flow during noncontact oxidation is significantly less for noncontact mode than for contact oxidation, although the resulting oxide volume is nearly identical. Ionization of water layers and mobile charge reorganization prior to and following meniscus formation is also shown to alter the tip-substrate capacitance and, therefore, the bending of the SPM cantilever.
A Study to Evaluate the Safety, Tolerability, and Efficacy of Brodalumab in Subjects with Rheumatoid Arthritis and an Inadequate Response to Methotrexate (2015)

Our study failed to find evidence of meaningful clinical efficacy with brodalumab treatment in subjects with RA who had an inadequate response to MTX. These preliminary results do not support further evaluation of brodalumab as a treatment for RA. Clinicaltrials.gov number: NCT00950989.
An approach towards the development of refreshable Braille Computer Display Unit (2019)

Modern time is the age of digitalization. People are accessing information with the advancement of digital technology. Blinds have very limited accessible resources to access this digitalized information. In this article, a novel proposal about working and development of an electronic refreshable braille display unit to build a getaway to the digital world for the blind people. An economic adoption of a tactile display having an array of six small independent vibrator motors are arranged in an array of a 3×2 matrix. The system would be enabled to initially capture information from computer screen then with suitable image processing, characters recognition and stimulation of target motor/s would enable enhanced readability of the texts.
Implications of a 2005 Measles Outbreak in Indiana for Sustained Elimination of Measles in the United States (2006)

This outbreak was caused by the importation of measles into a population of children whose parents had refused to have them vaccinated because of safety concerns about the vaccine. High vaccination levels in the surrounding community and low rates of vaccine failure averted an epidemic. Maintenance of high rates of vaccination coverage, including improved strategies of communication with persons who refuse vaccination, is necessary to prevent future outbreaks and sustain the elimination of measles in the United States.
Will we ever use stem cells for the treatment of SUI?: ICI‐RS 2011 (2012)

Larger and longer-term clinical trials are needed. Nonetheless, efficacious SC-based therapy for the treatment of SUI is practical, achievable and should be available as a treatment modality in the near future.
Suppression of SERK gene expression affects fungus tolerance and somatic embryogenesis in transgenic lettuce (2008)

The Somatic embryogenesis receptor-like kinase (SERK) gene plays an important role in plant somatic and zygotic embryogenesis induction. The gene encodes an LRR-containing receptor-like kinase protein. Studies have been carried out focusing on different aspects of its function, but definitive conclusions on its role are far from being reached. SERK expression is generally detected in cells in which somatic or zygotic embryogenesis has been triggered. Transgenic lettuce lines were produced to silence the endogenous SERK gene using antisense RNA. The average number of seeds per flower in the R(1) and R(2) generations was similar for both transgenic and non-transgenic lines. However, a reduction in the number of viable grained seeds was observed in four studied transgenic lines. Endogenous SERK expression analysis revealed the absence of detectable LsSERK gene transcripts in three transgenic lines, which presented a reduction in their ability to form in vitro somatic embryonic structures. In addition, transgenic lines showed enhanced susceptibility to the pathogenic fungus Sclerotinia sclerotiorum, when compared to control plants. The results support the idea that SERK genes might not only be involved in plant growth and development, but probably also in a general mechanism of biotic and abiotic stress perception.
Active sampling for graph-aware classification (2017)

The present work deals with data-adaptive active sampling of graph nodes representing training data for binary classification. The graph may be given or constructed using similarity measures among nodal features. Leveraging the graph for classification builds on the premise that labels over neighboring nodes are correlated according to a categorical Markov random field (MRF). This model is further relaxed to a Gaussian (G)MRF with labels taking continuous values, an approximation that not only mitigates the combinatorial complexity of the categorical model, but also offers optimal unbiased soft predictors of the unlabeled nodes. The proposed sampling strategy is based on querying the node whose label disclosure is expected to inflict the largest expected mean-square deviation on the GMRF, a strategy which subsumes the existing variance-minimization-based sampling method. A simple yet effective heuristic is also introduced for increasing the exploration capabilities, and reducing bias of the resultant estimator, by taking into account the confidence on the model label predictions. The novel sampling strategy is based on quantities that are readily available without the need for model retraining, rendering it scalable to large graphs. Numerical tests using synthetic and real data demonstrate that the proposed methods achieve accuracy that is comparable or superior to the state-of-the-art even at reduced runtime.
Photochemistry of the H2O/CO System Revisited: The HXeOH···CO Complex in a Xenon Matrix (2017)

We report on the complex of a noble-gas hydride HXeOH with carbon monoxide. This species is prepared via the annealing-induced H + Xe + OH···CO reaction in a xenon matrix, the OH···CO complexes being produced by VUV photolysis of the H<sub>2</sub>O···CO complexes. The H-Xe stretching mode of the HXeOH···CO complex absorbs at 1590.3 cm<sup>-1</sup> and it is blue-shifted by 12.7 cm<sup>-1</sup> from the H-Xe stretching band of HXeOH monomer. The observed blue shift indicates the stabilization of the H-Xe bond upon complexation, which is characteristic of complexes of noble-gas hydrides. The HXeOH···CO species is the first complex of a noble-gas hydride with carbon monoxide and the second observed complex of HXeOH. On the basis of the MP2/aug-cc-pVTZ-PP calculations, the experimental complex is assigned to the structure, where the carbon atom of CO interacts with the oxygen atom of HXeOH.
Genetic Typing and HIV-1 Diagnosis by Using 96 Capillary Array Electrophoresis and Ultraviolet Absorption Detection (2000)

Current high-throughput approaches to the analysis of PCR products are based primarily on electrophoretic separation and laser-excited fluorescence detection. We show that capillary array electrophoresis can be applied to HIV-1 diagnosis and D1S80 VNTR genetic typing based simply on UV absorption detection. The additive contribution of each base pair to the total absorption signal provides adequate detection sensitivity for analyzing most PCR products. Not only is the use of specialized and potentially toxic fluorescent labels eliminated, but also the complexity and cost of the instrumentation are greatly reduced.
Wireless chip to chip interconnections for murtichip modules using leaky wave antennas (1993)

A novel interchip communication technique for very high speed multichip modules is presented. The feasibility of using a dielectric guide leaky wave antenna integrated on a chip for transmission and reception is discussed. J-band measurements and predictions based on a model developed using the transmission line matrix (TLM) method are compared
Pthreads for Dynamic and Irregular Parallelism (1998)

High performance applications on shared memory machines have typically been written in a coarse grained style, with one heavyweight thread per processor. In comparison, programming with a large number of lightweight, parallel threads has several advantages, including simpler coding for programs with irregular and dynamic parallelism, and better adaptability to a changing number of processors. The programmer can express a new thread to execute each individual parallel task; the implementation dynamically creates and schedules these threads onto the processors, and effectively balances the load. However, unless the threads scheduler is designed carefully, the parallel program may suffer poor space and time performance. In this paper, we study the performance of a native, lightweight POSIX threads (Pthreads) library on a shared memory machine running Solaris; to our knowledge, the Solaris library is one of the most efficient user-level implementations of the Pthreads standard available today. To evaluate this Pthreads implementation, we use a set of parallel programs that dynamically create a large number of threads. The programs include dense and sparse matrix multiplies, two N-body codes, a data classifier, a volume rendering benchmark, and a high performance FFT package. We find the existing threads scheduler to be unsuitable for executing such programs. We show how simple modifications to the Pthreads scheduler can result in significantly improved space and time performance for the programs; the modified scheduler results in as much as 44% less running time and 63% less memory requirement compared to the original Pthreads implementation. Our results indicate that, provided we use a good scheduler, the rich functionality and standard API of Pthreads can be combined with the advantages of dynamic, lightweight threads to result in high performance.
[Is cholecystectomy by celiovideoscopy dangerous in the initial period? Prospective study of 100 initial cases]. (1992)

The aim of this study was to prospectively study the complication rate of our 100 initial laparoscopic cholecystectomies. The ultimate goal was to obtain a morbidity rate comparable to open cholecystectomy. No major complications were noticed. The conversion rate to open cholecystectomy was 8%, slightly higher in comparison with the literature. Absence of major complications could be explained by: a) indications limited to symptomatic non complicated cholelithiasis; b) assistance at the beginning of our experience of gynecologists used to laparoscopic techniques; c) conversion to open cholecystectomy in case of technical difficulties. Application of these principles allows the digestive surgeon to start laparoscopic cholecystectomy without submitting the patient to additional risks.
Induction of AhR-Mediated Gene Transcription by Coffee (2014)

By using culture medium-free experimental settings, we have shown that coffee is a strong AhR activator. Our observation may help elucidate as-yet-unrecognized effects of coffee on human health.
Cluster-based Simulated Annealing for Mapping Cores onto 2D Mesh Networks on Chip (2008)

In network-on-chip (NoC) application design, core-to-node mapping is an important but intractable optimization problem. In the paper, we use simulated annealing to tackle the mapping problem in 2D mesh NoCs. In particular, we combine a clustering technique with the simulated annealing to speed up the convergence to near-optimal solutions. The clustering exploits the connectivity and distance relation in the network architecture as well as the locality and bandwidth requirements in the core communication graph. The annealing is cluster-aware and may be dynamically constrained within clusters. Our experiments suggest that simulated annealing can be effectively used to solve the mapping problem with a scalable size, and the combined strategy improves over the simulated annealing in execution time by up to 30% without compromising the quality of solutions.
Prevalencia y carga parasitaria mensual de nematodos gastrointestinales y Fasciola hepatica en bovinos lecheros de dos distritos del Valle del Mantaro, Junín, Perú (2020)

El objetivo del presente estudio fue determinar la prevalencia y carga parasitaria mensual de nematodos gastrointestinales y Fasciola hepatica en bovinos lecheros de los distritos Nueve de Julio y Matahuasi de el Valle del Mantaro (Junín, Perú), así como los factores epidemiológicos asociados a estas parasitosis. Se recolectaron muestras mensuales de heces de 11 establos lecheros de cada distrito durante un año. Las muestras fueron analizadas con la técnica de Dennis modificado para la detección y conteo de huevos de F. hepatica y la técnica McMaster modificada para los huevos de nematodos. Se utilizó la prueba de regresión logística mixta para evaluar las variables distrito, época del año, sistema de alimentación, edad, temperatura, precipitación y humedad como posibles factores de riesgo. La prevalencia promedio mensual en Matahuasi y Nueve de Julio para nematodos gastrointestinales fue de 24.5 y 30.3%, con cargas mensuales de 118.3 y 87.4 hpg, y para F. hepatica de 69.8 y 46.6%, con cargas mensuales de 7.5 y 3 hpg, respectivamente. Los resultados indican que la nematodiasis gastrointestinal y fasciolosis hepática son endémicos en la zona. La presencia de nematodos está significativamente asociado al incremento de temperatura y la edad, siendo las terneras la población más susceptible, mientras que la fasciolasis está relacionada con el incremento de temperatura y precipitación, y la época del año, siendo significativamente mayor en época seca. Así mismo, se encontró una relación significativa entre la presencia de F. hepatica y el distrito de procedencia, siendo el riesgo de infección significativamente mayor en Matahuasi.
An Ad-hoc Distributed Reasoning Scheme for Content Centric Networking (2012)

Intelligently discovering knowledge and principles hidden in massive amounts of distributed and dynamic sources is a challenging issue, since the connectivity of sources and mobility of contents are frequent changing. For achieving intelligently discovering knowledge and principles in network environments, it requires a strong adaptive mechanism of distributed reasoning to discover the indirect and dynamic semantics in content-centric networking. In this paper, we propose a novel ad-hoc scheme for distributed reasoning by extending the name-based routing mechanism in content centric networking. The ad-hoc scheme of distributed reasoning is a native process of the content-centric networking. First, a two-stage reasoning mechanism is presented for reasoning query forwarding and knowledge reasoning. And then for guiding original or evolved queries to all right sources and supporting the knowledge integration in the way back, a recursive reasoning procedure and various reasoning rules are introduced.
Famous Operations (1984)

Professor Harold Ellis (Westminster Medical School, London) has provided an informative and delightful description of 16 famous operations. He chose five because they were major breakthroughs in surgical service, four because they were innovations in technique, and seven because although they were standard operations, they were performed on famous persons. Written with the low-key incisive wit characteristic of this warm humanist, each is a short essay that not only describes the operative procedure, but provides a glimpse of the state of the art and history of the times. Each chapter is short enough to be consumed as a morsel of informative bedside reading. There is nothing stuffy, dry, or pedantic in these pithy essays—neither is their author, whose wry comments enlighten almost every page.
Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation (2020)

Our results suggest that Fc-dependent antibody function and quality, exemplified by NK cell activation and glycosylation, contribute to protection against severe RSV disease and warrant further studies to evaluate the potential of using these properties to evaluate and improve the efficacy of novel vaccines.
Local Disorder Facilitates Chain Stretching in Crowded Polymer Brushes (2020)

Intermolecular crowding of densely tethered polymers promotes chain extension and anisotropy that induces many unique properties. In this study, we used conformation-sensitive infrared spectroscopy to determine that chain extension in a polymer brush is associated with local conformation rearrangements, i.e., contraction of side groups and increased proportion of <i>gauche</i> twists in the backbone, which served to increase molecular disorder at or below the segmental scale. This conformational transition points to a particular molecular mechanism for chain extension in densely tethered polymers, wherein increased local disorder facilitates global chain ordering (i.e., chain extension) and therefore supplements our current understanding of chain orientation at a molecular level.
Backside-illuminated photoelectrochemical etching for the fabrication of deeply undercut GaN structures (2000)

A photoelectrochemical (PEC) wet-etching technique (backside-illuminated PEC) is described that utilizes the dopant or band-gap selectivity of PEC etching to fabricate deeply undercut structures. Lateral etch rates exceeding 5 μm/min have been observed, producing cantilevers in excess of 100μm in length. Dramatically different etch morphologies were noted between the frontside- and backside-illuminated etching, though dopant-dependent etch selectivities were maintained.