gebhart/patrepeval huggingface dataset:
Effect of Epinephrine, Norepinephrine and(or) GnRH on Serum LH in Prepuberal Beef Heifers (1983)

Forty prepuberal Simmental X Brahman-Hereford heifers were utilized to determine the effects of epinephrine (E), norepinephrine (NE), gonadotropin releasing hormone (GnRH) or combinations of GnRH + E and GnRH + NE on serum luteinizing hormone (LH) concentrations. Animals were assigned randomly to one of five treatments with four replicates/treatment. Treatments consisted of I) 100 micrograms GnRH at time 0 (n = 8); II) 50 mg NE at time -15 and 0 (n = 8); III) 50 mg E at time -15 and 0 (n = 8); IV) 100 micrograms GnRH at time 0, plus 50 mg NE at time -15 and 0 (n = 8) and V) 100 micrograms GnRH at time 0, plus 50 mg E at time -15 and 0 (n = 8). All treatment compounds were administered im in 2 ml physiological saline and blood samples were collected via tail vessel puncture at -30, -15, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 and 360 min from GnRH injection. Treatment with NE or E alone had no effect (P greater than .10) on serum LH during the sampling period. The initial LH release to GnRH was altered (P less than .05) by concomitant treatment with NE (treatment IV) or E (treatment V). Magnitude of the LH release was reduced (P less than .01) by treatment V. Area under the LH surge was reduced (P less than .05) by treatment IV (NE) and V (E).
FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children (2016)

Regulatory T cells (Tregs) are functionally suppressive CD4 T cells, critical for establishing peripheral tolerance and controlling inflammatory responses. Previous reports of Tregs during chronic HIV disease have conflicting results with higher or lower levels compared with controls. Identifying true Tregs with suppressive activity proves challenging during HIV infection, as traditional Treg markers, CD25 and FOXP3, may transiently upregulate expression as a result of immune activation (IA). Helios is an Ikaros family transcription factor that marks natural Tregs with suppressive activity and does not upregulate expression after activation. Coexpression of FOXP3 and Helios has been suggested as a highly specific marker of "bona fide" Tregs. We evaluated Treg subsets by FOXP3 coexpressed with either CD25 or Helios and their association with HIV disease progression in perinatally infected HIV-positive children. Identifying Tregs by FOXP3 coexpression with Helios rather than CD25 revealed markedly higher Treg frequencies, particularly in HIV+ children. Regardless of antiretroviral therapy, HIV-infected children had a selective expansion of memory FOXP3+Helios+ Tregs. The rise in memory Tregs correlated with declining HIV clinical status, indicated by falling CD4 percentages and CD4:CD8 ratios and increasing HIV plasma viremia and IA. In addition, untreated HIV+ children exhibited an imbalance between the levels of Tregs and activated T cells. Finally, memory Tregs expressed IA markers CD38 and Ki67 and exhaustion marker, PD-1, that tightly correlated with a similar phenotype in memory CD4 T cells. Overall, HIV-infected children had significant disruptions of memory Tregs that associated with advancing HIV disease.
Emergent properties of composite semiflexible biopolymer networks (2014)

The semiflexible polymers filamentous actin (F-actin) and intermediate filaments (IF) both form complex networks within the cell, and together are key determinants of cellular stiffness. While the mechanics of F-actin networks together with stiff microtubules have been characterized, the interplay between F-actin and IF networks is largely unknown, necessitating the study of composite networks using mixtures of semiflexible biopolymers. We employ bulk rheology in a simplified in vitro system to uncover the fundamental mechanical interactions between networks of the 2 semiflexible polymers, F-actin and vimentin IF. Surprisingly, co-polymerization of actin and vimentin can produce composite networks either stronger or weaker than pure F-actin networks. We show that this effect occurs through steric constraints imposed by IF on F-actin during network formation and filament crosslinking, highlighting novel emergent behavior in composite semiflexible networks.
An engineered promoter driving expression of a microbial avirulence gene confers recognition of TAL effectors and reduces growth of diverse Xanthomonas strains in citrus (2016)

Xanthomonas citri ssp. citri (X. citri), causal agent of citrus canker, uses transcription activator-like effectors (TALEs) as major pathogenicity factors. TALEs, which are delivered into plant cells through the type III secretion system (T3SS), interact with effector binding elements (EBEs) in host genomes to activate the expression of downstream susceptibility genes to promote disease. Predictably, TALEs bind EBEs in host promoters via known combinations of TALE amino acids to DNA bases, known as the TALE code. We introduced 14 EBEs, matching distinct X. citri TALEs, into the promoter of the pepper Bs3 gene (ProBs3<sub>1EBE</sub> ), and fused this engineered promoter with multiple EBEs (ProBs3<sub>14EBE</sub> ) to either the β-glucuronidase (GUS) reporter gene or the coding sequence (cds) of the pepper gene, Bs3. TALE-induced expression of the Bs3 cds in citrus leaves resulted in no visible hypersensitive response (HR). Therefore, we utilized a different approach in which ProBs3<sub>1EBE</sub> and ProBs3<sub>14EBE</sub> were fused to the Xanthomonas gene, avrGf1, which encodes a bacterial effector that elicits an HR in grapefruit and sweet orange. We demonstrated, in transient assays, that activation of ProBs3<sub>14EBE</sub> by X. citri TALEs is T3SS dependent, and that the expression of AvrGf1 triggers HR and correlates with reduced bacterial growth. We further demonstrated that all tested virulent X. citri strains from diverse geographical locations activate ProBs3<sub>14EBE</sub> . TALEs are essential for the virulence of X. citri strains and, because the engineered promoter traps are activated by multiple TALEs, this concept has the potential to confer broad-spectrum, durable resistance to citrus canker in stably transformed plants.
Examining CO 2 as an Additive for Solid Electrolyte Interphase Formation on Silicon Anodes (2021)

We demonstrate that the addition of CO 2 to a standard 1.0 M LiPF 6 3:7 wt% ethylene carbonate:ethyl methyl carbonate electrolyte results in the formation of a thinner insoluble solid electrolyte interphase (SEI) that is dominated by the presence of LiF. In contrast, cells without CO 2 result in a thicker insoluble SEI layer containing more organic constituents. The CO 2 is incorporated in the dimethyl carbonate soluble part of the SEI composed primarily of polymeric poly(ethylene oxide) (PEO) on the surface of a thin inorganic layer. This combination of properties from CO 2 addition provides an improved cycling performance through the reduction of irreversible side reactions, leading to higher coulombic efficiency. The results indicate that CO 2 incorporates into the SEI and plays a role similar to additives like fluorinated ethylene carbonate and vinylene carbonate with respect to polymeric components.
Impaired Hypoxic Coronary Vasodilation and ATP-Sensitive Potassium Channel Function (2003)

Hypoxic coronary vasodilation contributes to themaintenance of oxygen supply to the working heartduring increased metabolic demand. Mechanisms of hypoxic coronary dilation have been studied extensively and differ considerably depending upon the species and experi-mental model. In isolated coronary vessels, several mecha-nisms have been implicated either alone or in combination, including release of vasodilatory factors (ie, nitric oxide, prostaglandins, and adenosine), activation of ATP-sensitive potassium (KATP) channels and Ca2-activated K channels, and inhibition of voltage-gated Ca2 channels.1–5 To date, however, relatively few studies have been conducted in human blood vessels. Furthermore, whereas most prior stud-ies have examined hypoxic dilation in conduit coronary arteries, coronary microvessels (150 m in diameter) are considered to be the principal regulators of coronary blood flow in response to metabolic stress.6 Thus, despite extensive
A tool for learning logic circuits (2001)

We propose a tool with which everybody can learn logic circuits. After opening the program window, subwindows for (1) random NAND circuit, (2) arbitrary NAND circuit and (3) logic circuit learning program are displayed for selection. Once for instance the item (2) is chosen, a truth table will be prompted for input. Then either the true value (1) or the false value (0) will be clicked by a mouse, for circuit's input condition. Next, using MA method, a preliminary circuit composed of NAND gates only is generated. The circuit can be altered later. Also by choosing the item (3), one can easily understand the relationship between the input and output logics in the various basic logic states.
Supplementary Information and Data from The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas (2023)

&lt;p&gt;The supplementary information file contains details about primers used for this work, supplementary Figures S1-S8, supplementary Table S1, and results from cell line authentication and from mycoplasma testing.&lt;/p&gt;
Metal-Oxide-Hydrogel Field-Effect Sensor (2018)

Hydrogels have an open cavity and porous micro-structures enabling various gases and liquids to diffuse rapidly through them and simultaneously changing their resistance, refractive index, density, color and other properties. Hence, they are ideal as programmable sensing materials. They can be, relatively easily programmed by diffusing acids, bases or ionic/non-ionic liquids or by adding nano-particles, which in addition to acting as electric or magnetic field focusing or modifying materials, add their own chemical/gas response characteristics to the hydrogel matrix element. Here we report applications of a MOSFET-like device with active channels formed by hydrogels with embedded gold nano-particles (AuNP) in gas and liquid sensing. The device consists of an open-face field effect transistor structure that can be used with different channel materials deposited directly on the device forming its active channel. The resulting metal-oxide hydrogel field-effect transistor (MOHFET) was then used to detect ethyl alcohol both in liquids and in gas phase. The sensor response was measured for ethyl alcohol gas after preconditioning the hydrogel channel in PBS (sensitivity: 2.6 μA/ml) and deionized (DI) water media (sensitivity: 7.4 μA/ml). The sensor sensitivity to ethyl alcohol in solution was 8.2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> A/ml.
Progress Toward Transition Edge Sensor Arrays With On-Chip Thermal Stabilization (2023)

Electrothermal feedback in a transition edge sensor (TES) suppresses thermal fluctuations in the TES and well-thermally coupled regions in proximity. We have designed a heavily metallized, leg-isolated membrane with a TES which serves as a thermal isolation stage that can be lithographically integrated with other devices, for example, a suitably designed TES detector. Through modeling, fabrication, and test of prototype devices, we plan to examine the utility of stabilizing this guard stage to limit low frequency variability in the sensor response. In one implementation, a leg-isolated TES bolometer of higher superconducting transition temperature (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T<sub>c</sub></i>) is encircled by a second membrane region which is metallized and thermally stabilized by a second, lower-<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T<sub>c</sub></i> TES. We present fabrication results on the dual-<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T<sub>c</sub></i> device and explore varied heat capacity of the thermal stability stage in the single-pixel design. We then evaluate the use of this stage for multiple pixel arrangements and investigate the criteria for stabilizing such a device.
The MOS controlled super junction transistor (SJBT): a new, highly efficient, high power semiconductor device for medium to high voltage applications (2003)

The paper presents a new MOS controlled silicon power device with columnar super junction structures. The super junction bipolar transistor (SJBT) is an extension of the super junction MOSFET principle: due to it's p-emitter at the anode the device is bipolar in nature albeit with substantially different characteristics as compared to an IGBT. It's electrical performance rivals advanced trench IGBTs.
Broadband Eight-Way Substrate Integrated Waveguide Radial Power Divider/Combiner With High-Isolation (2020)

A broadband eight-way substrate integrated waveguide (SIW) radial power divider/combiner with high-isolation is presented. The step probes are utilized to achieve broadband impedance matching and improve the return loss. What's more, the star structure based on microstrip circuit is employed to improve the isolation performance. A two-layer SIW radial power divider/combiner is designed, fabricated and measured. Good agreement between simulated and measured results is achieved for the proposed power divider/combiner. The measured results show that both bandwidths of the input and output port are 25% and 20% when their return loss are lower than -15 dB. The measured output isolation is greater than 17.5 dB from 5.75 GHz to 7.85 GHz and greater than 20 dB from 6.8 GHz to 7.9 GHz. The presented eight-way SIW power divider/combiner has the advantage of wider bandwidth, lower return loss and insertion loss, and higher isolation between the outputs.
Development of active gratings for the spectral selection of ultrafast pulses (2013)

We present the design, realization and characterization of active deformable gratings for extreme-ultraviolet monochromators for ultrashort pulses. The core device consists of a bimorph deformable mirror on the top of which a diffraction grating with laminar profile is realized by UV lithography. The curvature radius of the grating substrate can be varied changing the voltage applied to an underlying piezo-actuator. The advantage of this technology is to provide gratings with high optical quality, robust, compatible with any coating deposition and realized with only vacuumcompatible materials. We present the characterization of a time-delay compensated monochromator realized with these devices, showing that the active grating can optimize the beam focusing through its rotation and deformation. Two equal active gratings have been mounted in a compensated configuration to realize a grazing-incidence double-grating monochromator for the spectral selection of ultrashort pulses and the simultaneous compensation of the pulse front-tilt given by the diffraction. The wavelength scanning is performed by the first grating through rotation. The radiation is focused on the intermediate plane, where a slit carries out the spectral selection. Finally, the second grating compensates for the pulse front-tilt given by the first one. The spectral focusing of both gratings is maintained at the different wavelengths through the variation of the radii of curvature. The instrument has been tested with a Ti:Sa laser operated at 800 nm. We have been able to demonstrate that the double-grating configuration with active gratings compensates for the pulse front-tilt, that is reduced from 1 ps at the intermediate plane to 100 fs at the output. The final value is limited by the group delay dispersion of the monochromator within the 10-nm bandwidth of the laser. A configuration for the selection on XUV ultrashort pulses has been theoretically studied and the expected performances presented. Active gratings may be considered as a cheaper and more flexible alternative to standard gratings for the realization of extremeultraviolet monochromators for ultrafast pulses, such as free-electron lasers and high-order laser harmonics.
Implementation of a High Resolution Bloodflow Imaging System Using Large Time Bandwidth Product Pseudo-Noise Sequences (1978)

Our previous work on high resolution blood flow measurement was related to the statistical model of flowing blood and to optimum techniques for detecting bloodflow signals. We additionally reported on basic limitations which affect the overall system design. These constraints interrelate Doppler and range resolution, blood velocity and its profile, system bandwidth, signal duration, transducer beamwidth and other system parameters. of a practical bloodflow imaging system using binary phase coded PN sequences as the transmitted waveform. The particular hardware implementation reported here will allow a real time display of typical velocity profiles normally encountered. In this paper we integrate these results in the design
Supplementary Figure 4 from Oncogenic MUC1-C Promotes Tamoxifen Resistance in Human Breast Cancer (2023)

&lt;p&gt;PDF file - 338K, 293T cells were left untreated or treated with G0-203 each day for 4 days. The results (mean plus-minus SD of three replicates) are expressed as the percentage of cell death as determined by trypan blue staining on day 4.&lt;/p&gt;
Introduction to Embedded Systems (2009)

actors Abstract signals Reorganiz e We seek an s  S N that satisfies F(s) = s. Such an s is called a fixed point. We would like the fixed point to exist and be unique. And we would like a constructive procedure to find it. It is the behavior of the system.
THE EFFECT OF ETHEPHON, NAA, BA AND THEIR COMBINATIONS ON THINNING INTENSITY OF 'SUMMERRED' APPLES (2003)

The chemical thinning of 'Summerred'/M.9 was investigated on three years old apple trees.The application of ethephon 200 ppm was done at the start of flowering time, 6-benzyladenine (BA) 100 ppm and 1naphthaleneacetic acid (NAA) 10 ppm was applied at 10 mm fruitlet diameter and the combination spraying of these thinners was done as a multiple (ethephon + BA, ethephon + NAA) or tank mix (BA + NAA) application.The alone application of ethephon or NAA reduced the final fruit number but did not enhance the mean fruit weight, similar as the consecutive (multiple) application of ethephon and NAA.On the contrary, when BA was applied (alone or in combination with ethephon) a nice fruit growth happened after the thinning of fruitlets.The tank mix spraying of BA + NAA reduced the fruit number adequately and the fruit growth was enhanced.The strongest thinning (overthinning) occurred when ethephon spraying was followed by the mixture of BA and NAA three weeks later.Significantly better return bloom was observed in the case of BA and NAA alone application, ethephon + BA, BA + NAA and ethephon + BA + NAA treatments.
Local displacement measurements within adhesives using particle tracking andIn Situcomputed tomography (2015)

Strain measurements are essential for understanding the mechanical behavior of bonded joints under different load conditions and for validating numeric simulations. Strain gauges and extensometers are typically used to determine local strains in a specific direction. The introduction of digital image correlation (DIC) allows for the full-field measurement of surface strains both in two dimension and in three dimension. However, these methods observe the strain of the adhesives’ surface which may vary in comparison to the volumetric strains.In this article, a new technique for measuring the internal displacement field in adhesives is proposed. The method is based on in situ x-ray computed tomography (CT) and particle tracking. Basic approach of the measurement is to identify and track characteristic markers within adhesives during loading. The displacement due to the load can be calculated by the different positions of the characteristic markers between two image sets. Initial results for a single lap joint with a thick bond line indicate that a sufficient resolution of the measurement can be reached and motivate further research to develop this novel measurement technique for adhesives.
Mastering Lotus Notes (1994)

Ｎｏｔｅｓを使う Ｎｏｔｅｓの基本を理解する Ｎｏｔｅｓの環境下で作業する Ｎｏｔｅｓデータベースにアクセスする データベースの中身を見る 文書を作成する 文字列の検索と置換をする ビューや文書を印刷する データの読み込み・書き出しを行う データの貼り付けや添付をする Ｎｏｔｅｓメールで通信する ダイヤルアップＮｏｔｅｓを使用する 保守・カスタマイズを行う
Emergence of New Delhi Metallo-β-Lactamase, Austria (2010)

Emergence of New Delhi
Optimal management of idiopathic macular holes (2016)

This review evaluates the current surgical options for the management of idiopathic macular holes (IMHs), including vitrectomy, ocriplasmin (OCP), and expansile gas use, and discusses key background information to inform the choice of treatment. An evidence-based approach to selecting the best treatment option for the individual patient based on IMH characteristics and patient-specific factors is suggested. For holes without vitreomacular attachment (VMA), vitrectomy is the only option with three key surgical variables: whether to peel the inner limiting membrane (ILM), the type of tamponade agent to be used, and the requirement for postoperative face-down posturing. There is a general consensus that ILM peeling improves primary anatomical hole closure rate; however, in small holes (<250 µm), it is uncertain whether peeling is always required. It has been increasingly recognized that long-acting gas and face-down positioning are not always necessary in patients with small- and medium-sized holes, but large (>400 µm) and chronic holes (>1-year history) are usually treated with long-acting gas and posturing. Several studies on posturing and gas choice were carried out in combination with ILM peeling, which may also influence the gas and posturing requirement. Combined phacovitrectomy appears to offer more rapid visual recovery without affecting the long-term outcomes of vitrectomy for IMH. OCP is licensed for use in patients with small- or medium-sized holes and VMA. A greater success rate in using OCP has been reported in smaller holes, but further predictive factors for its success are needed to refine its use. It is important to counsel patients realistically regarding the rates of success with intravitreal OCP and its potential complications. Expansile gas can be considered as a further option in small holes with VMA; however, larger studies are required to provide guidance on its use.
Apports du réhaussement à l'étude du rôle de l'enveloppe temporelle dans l'identification de la parole : application à la compensation des troubles d'intelligibilité d'origine neurosensorielle (2002)

Le but de cette recherche consiste à étudier le rôle de l'enveloppe temporelle (les fluctuations lentes d'amplitude, &lt;500 Hz) dans la perception de la parole. Cinq études psychoacoustiques examinent les effets d'un rehaussement (ou expansion) d'enveloppe temporelle sur l'identification de la parole chez les sujets normo-entendants et malentendants. Les capacités d'identification sont mesurées dans le silence et en présence d'un bruit stationnaire ou fluctuant, à l'aide de stimuli de type CV, VCV ou de phrases. Dans les deux premières études, les stimuli de parole sont dégradés spectralement alors que dans les trois études suivantes, les stimuli sont préservés dans le domaine spectral. Deux algorithmes d'expansion sont utilisés afin d'augmenter le contraste de l'inveloppe des stimuli....