gebhart/patrepeval huggingface dataset:
Supplementary Tables 1-7 from Establishment and Characterization of an <i>In Vitro</i> Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity (2023)

&lt;p&gt;Supplementary Table S1. Information on clinical data of SOCs and sphere formation. Supplementary Table S2. Xenograft tumor formation assay of the ovarian spheroids (#4). Supplementary Table S3. Limited dilution assay on the FACS-sorted spheroid cells. Supplementary Table S4. Clinicopathological features of high-grade serous ovarian carcinoma patients. Supplementary Table S5. Statistical analyses of ALDH1A1 expression in advanced-stage high-grade serous ovarian carcinoma. Supplementary Table S6. Limited dilution assays for the sh-ALDH1A1-infected cells. Supplementary Table S7. Limited dilution assays for the sh-SOX2-infected cells.&lt;/p&gt;
Laser based multiple gas species sensor for harsh combustion process control applications (2004)

Results from a tunable diode laser system for simultaneously monitoring of O/sub 2/, CO, H/sub 2/O and gas temperature are presented for laboratory characterization studies and industrial testing on a steel reheat furnace and aluminum reverberatory furnace.
Politiques publiques et pratiques de traitement de la délinquance juvénile: une relation de conditionnement réciproque (2002)

Pas de résumé
ChemInform Abstract: Heck Reactions Using Segmented Flow Conditions. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data from Brief Report: Combination of Osimertinib and Dacomitinib to Mitigate Primary and Acquired Resistance in <i>EGFR</i>-Mutant Lung Adenocarcinomas (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Primary and acquired resistance to osimertinib remain significant challenges for patients with &lt;i&gt;EGFR&lt;/i&gt;-mutant lung cancers. Acquired &lt;i&gt;EGFR&lt;/i&gt; alterations such as &lt;i&gt;EGFR&lt;/i&gt; T790M or C797S mediate resistance to EGFR tyrosine kinase inhibitors (TKI) and combination therapy with dual EGFR TKIs may prevent or reverse on-target resistance.&lt;/p&gt;Patients and Methods:&lt;p&gt;We conducted two prospective, phase I/II trials assessing combination osimertinib and dacomitinib to address on-target resistance in the primary and acquired resistance settings. In the initial therapy study, patients received dacomitinib and osimertinib in combination as initial therapy. In the acquired resistance trial, dacomitinib with or without osimertinib was administered to patients with &lt;i&gt;EGFR-&lt;/i&gt;mutant lung cancers with disease progression on osimertinib alone and evidence of an acquired &lt;i&gt;EGFR&lt;/i&gt; second-site mutation.&lt;/p&gt;Results:&lt;p&gt;Cutaneous toxicities occurred in 93% (any grade) of patients and diarrhea in 72% (any grade) with the combination. As initial therapy, the overall response to the combination was 73% [95% confidence interval (CI), 50%–88%]. No acquired secondary alterations in &lt;i&gt;EGFR&lt;/i&gt; were observed in any patients at progression. In the acquired resistance setting, the overall response was 14% (95% CI, 1%–58%).&lt;/p&gt;Conclusions:&lt;p&gt;We observed no acquired secondary EGFR alterations with dual inhibition of EGFR as up-front treatment, but this regimen was associated with greater toxicity. The combination was not effective in reversing acquired resistance after development of a second-site acquired EGFR alteration. Our study highlights the need to develop better strategies to address on-target resistance in patients with &lt;i&gt;EGFR&lt;/i&gt;-mutant lung cancers.&lt;/p&gt;&lt;/div&gt;
Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals (2011)

Abstract Scandium isotopes ( 44 Sc, 47 Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by 45 Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA &lt; NOTA &lt; EDTA &lt; DTPA &lt; DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.
Evaluating Thermal Quenching Temperature in Eu3+-Substituted Oxide Phosphors via Machine Learning (2019)

One of society's grand challenges is to reduce energy usage in ways that are cost-effective, sustainable, and environmentally benign. Replacing incandescent and compact fluorescent light bulbs with energy-efficient, solid-state white lighting is one of the easiest and most promising solutions. Eu<sup>3+</sup>-substituted inorganic oxide phosphors are one class of materials that can serve as the red component in these new light bulbs, allowing the creation of warm white light. Unfortunately, the emission intensity in most of these materials cannot be reliably maintained at elevated temperatures. There is therefore a need to discover entirely novel phosphor materials that are thermally robust; however, this is generally a prolonged and expensive process requiring extensive synthetic effort. In this work, we develop a machine-learning regression algorithm based on 134 experimentally measured temperature-dependent Eu<sup>3+</sup> emission data points to rapidly estimate the thermal quenching temperature (<i>T</i><sub>50</sub>), which is defined as the temperature when the emission intensity is half of the initial value. The <i>T</i><sub>50</sub> was then predicted for more than 1000 potential oxide Eu<sup>3+</sup> phosphor hosts using this model. Five compounds with predicted thermal quenching temperatures >423 K were subsequently selected and synthesized for validation of this approach. The phosphors, Sr<sub>2</sub>ScO<sub>3</sub>F, Cs<sub>2</sub>MgSi<sub>5</sub>O<sub>12</sub>, Ba<sub>2</sub>P<sub>2</sub>O<sub>7</sub>, LiBaB<sub>9</sub>O<sub>15</sub>, and Y<sub>3</sub>Al<sub>5</sub>O<sub>12</sub>, all exhibit good thermal stability when substituted with Eu<sup>3+</sup>, suggesting the success of our methodology.
Evaluation of pituitary function in children using growth hormone secretagogues. (1996)

We have devised a diagnostic test to directly evaluate pituitary secretory potential, and also to identify the most appropriate therapy for slow growing children. The test compares responses to GH releasing hormone (GHRH) and GH releasing peptides or their non-peptidyl mimics (GHRP) administered sequentially and in combination. Since they are functional complements, robust GH secretion in response to GHRH or GHRP could be interpreted as representing adequate endogenous GHRP or GHRH, respectively. Alternatively, assuming that all pituitary cellular and molecular elements for GHRH- and GHRP-mediated GH secretion are functional, a poor response to either GH secretagogue administered individually could represent inadequacy of its endogenous complement. The integrity of functional pituitary elements could be differentiated from inadequate endogenous complement by administering both GH secretagogues simultaneously. Based upon this hypothesis, the proposed pituitary function diagnostic scheme could be used to test for endogenous GH secretagogue adequacy, as well as pituitary secretory capacity. The data resulting from application of these principles would allow appropriate selection of therapeutic entities, ranging from GHRH or GHRP administered separately or in combination, or alternatively, recombinant GH for those patients lacking a pituitary mechanism for GH production and/or secretion.
A local optimisation method for obtaining material model parameters (2000)

A local optimisation method for obtaining material parameters in finite element simulations has been developed. The method is based on the minimisation of an error function which reflects the accuracy of a numerical prediction with respect to the results of simple specimen tests. The experimental data were obtained from high strain rate tensile tests on the alloy 90 per cent titanium – 6 per cent aluminium – 4 per cent vanadium (Ti6Al4V) using the tensile split‐Hopkinson pressure bar. The behaviour of the tensile specimen was monitored during the test using high‐speed photography and transient recorders. Finite element simulations were performed using ABAQUS/Explicit employing the Zerilli‐Armstrong material model for bcc metals).
Arginine Activity in the Proton-Motive Photocycle of Bacteriorhodopsin:  Solid-State NMR Studies of the Wild-Type and D85N Proteins (1999)

15N solid-state NMR (SSNMR) spectra of guanidyl-15N-labeled bacteriorhodopsin (bR) show perturbation of an arginine residue upon deprotonation of the retinal Schiff base during the photocycle. At the epsilon position, an upfield shift of 4 ppm is observed while the eta nitrogens develop a pair of 'wing' peaks separated by 24 ppm. Proton-driven spin diffusion between the two 'wing' peaks indicates that they arise from a single Arg residue. An unusually asymmetric environment for this residue is indicated by comparison with guanidyl-15N chemical shifts in a series of arginine model compounds. The 'wing' peaks are tentatively assigned to Arg-82 on the basis of the SSNMR investigations of the alkaline and neutral dark-adapted forms of the D85N bacteriorhodopsin mutant. Another, less asymmetric pair of eta signals, that is not affected by Schiff base deprotonation or D85 mutation, is tentatively assigned to Arg-134. The results are discussed in relation to existing models of bR structure and function.
The paradigm of ASIA (autoimmune/inflammatory syndrome induced by adjuvants): a concept in evolution. (2014)

Glenny and colleagues [5] described the first adjuvant effect of an aluminum compound in 1926, hypothesizing a “depot” effect and the ability to control the release of the antigen [6]. Later on, these hypotheses were questioned [7]. Today we know that an immunologic adjuvant is able to increase innate and adaptive immune responses to the injected antigen by means of several mechanisms. Indeed, the identification of Toll-like receptors as pattern-recognition receptors – responsible for recognizing evolutionary conserved molecules (i.e., lipopolysaccharide, skeletal cell wall components) and critical for sensing infections – added further insight to our understanding of the mechanisms of innate immunity in recent decades and, subsequently, of adjuvant function mechanisms. Adjuvants may act not only via TLR1-dependent mechanisms – by up-regulation of cytokines and MCH class II co-stimulatory molecules, promotion of dendritic cell migration to the T cell area of lymph node – but also via TLR-independent mechanisms by activating another class of PRR2, the NOD-like receptors, ultimately responsible for the activation of a molecular platform called inflammasome, as shown in the case of aluminum [8]. Undoubtedly, vaccines represent one of the greatest advances of modern medicine; they are considered safe and effective by the medical community for both the general population and many categories of subjects at risk, such as the elderly and immunocompromised individuals. Adverse reactions and post-immunization phenomena following different
Isodimorphe Substitution im CaSO4CaHPO4H2O‐System (1980)

Abstract Das CaSO 4 CaHPO 4 H 2 O‐System, durch gleichzeitigen Fällung von Gips und Brushit aus Lösungen, die Ca 2+ , HPO 4 2− und SO 4 2− erhalten, wird erstmals vollständig untersucht. Auf Grund von quantitativen IR‐ und röntgenographischen Untersuchungen wird die Bildung einer Unterbrochenen Reihe von Mischkristallen im erforschten System festgestellt. Die Unterbrechung der Mischkristallreihe ist auf die verschiedenartige Punktgruppensysmmetrie der SO 4 ‐Tetraeder (Td) und der HPO 4 ‐Tetraeder (C 3v )zurückzuführen, was auch die Ursache für die unterschiedliche Symmetrie der Struktur von Gips I2/a und von Bruschit Ia ist. Die Unterbrechung der Mischkristallreihe erfolgte bei einem Gehalt von CaSO 4 · 2H 2 O in der festen Phase von 20 bis 30%, beziehungsweise 80 und 70% CaHPO 4 · 2H 2 O. Die Substitution der deformierten HPO 4 ‐Tetraeder durch die Kleineren und regelmäßigeren SO 4 ‐Tetraeder führt wahrscheinlich zu einer Instabilität der Brushitstruktur, weshalb auch das Kristallisationsfeld der Mischkristalle, auf Grund der Brushitkristallstruktur wesentlich enger ist als diese der Mischkristalle, die auf der Basis der Gipskristallstruktur gebildet werden.
Quadrature Spatial Modulation for 5G Outdoor Millimeter–Wave Communications: Capacity Analysis (2017)

Capacity analysis for millimeter-wave (mmWave) quadrature spatial modulation (QSM) multiple-input multiple-output (MIMO) system is presented in this paper. QSM is a new MIMO technique proposed to enhance the performance of conventional spatial modulation (SM) while retaining almost all its inherent advantages. Furthermore, mmWave utilizes a wide-bandwidth spectrum and is a very promising candidate for future wireless systems. Detailed and novel analysis of the mutual information and the achievable capacity for mmWave-QSM system using a 3-D statistical channel model for outdoor mmWave communications are presented in this paper. Monte Carlo simulation results are provided to corroborate derived formulas. Obtained results reveal that the 3-D mmWave channel model can be closely approximated by a log-normal fading channel. The conditions under which capacity can be achieved are derived and discussed. It is shown that the capacity of QSM system can be achieved, by carefully designing the constellation symbols for each specific channel model.
CosTaL: an accurate and scalable graph-based clustering algorithm for high-dimensional single-cell data analysis (2023)

With the aim of analyzing large-sized multidimensional single-cell datasets, we are describing a method for Cosine-based Tanimoto similarity-refined graph for community detection using Leiden's algorithm (CosTaL). As a graph-based clustering method, CosTaL transforms the cells with high-dimensional features into a weighted k-nearest-neighbor (kNN) graph. The cells are represented by the vertices of the graph, while an edge between two vertices in the graph represents the close relatedness between the two cells. Specifically, CosTaL builds an exact kNN graph using cosine similarity and uses the Tanimoto coefficient as the refining strategy to re-weight the edges in order to improve the effectiveness of clustering. We demonstrate that CosTaL generally achieves equivalent or higher effectiveness scores on seven benchmark cytometry datasets and six single-cell RNA-sequencing datasets using six different evaluation metrics, compared with other state-of-the-art graph-based clustering methods, including PhenoGraph, Scanpy and PARC. As indicated by the combined evaluation metrics, Costal has high efficiency with small datasets and acceptable scalability for large datasets, which is beneficial for large-scale analysis.
Dementia Praecox or the Group of Schizophrenias (1951)

"Our literature is replete with complaints about the chaotic state of the systematics of psychoses and every psychiatrist knows that it is impossible to come to any common understanding on the basis of the old diagnostic labels.... Thus, not even the masters of science can make themselves understood on the basis of the old concepts and with many patients the number of diagnoses made equals the number of institutions they have been too.... Errors are the greatest obstacles to the progress of science; to correct such errors is of more practical value than to achieve new knowledge. We have here eliminated chaos of terms behind which useful concepts of disease were mistakenly sought; we have eliminated a veritable forest of boundary posts, not one of which indicated any natural line of demarcation.... By the term „dementia praecox“ or „schizophrenia“ we designate a group of psychoses whose course is at times chronic, at times marked by intermittent attacks, and which can stop or retrograde at any stage, but does not permit a full restitutio ad integrum. The disease is characterized by a specific type of alteration of thinking, feeling, and relation to the external world which appears nowhere else in this particular fashion." Eugen Bleuler. Dementia Praecox or the Group of Schizophrenias. Translated by Joseph Zinkin. International Universities Press, New York, 1950.
Pavement Design and Materials (2012)

The book offers coverage of the characterization of traffic input; the characterization of pavement bases/subgrades and aggregates; asphalt binder and asphalt concrete characterization; portland cement and concrete characterization; analysis of flexible and rigid pavements; pavement evaluation; environmental effects on pavements; pavement rehabilitation; economic analysis of alternative pavement design. The coverage is accompanied by suggestions for software for implementing various analytical techniques described in the chapters (Eksp ke: I) ( Rak 3 )
Towards Resource-aware Business Process development in the Cloud (2015)

In recent years, cloud environments have emerged as a new paradigm for the execution and the deployment of cost-reduced and optimized business processes. Nevertheless, due to the lack of explicit and formal description of the resource perspective in existing business processes, cloud resources cannot be efficiently and optimally managed. With the aim of formalizing the consumed cloud resources using a shared knowledge base, we propose in this paper a semantic framework for resource-aware business process development in the cloud. Basically, our proposed semantic framework allows for (1) resource description in a formal and unique way, (2) resource allocation management and (3) resource constraints verification. In order to show its feasibility, our approach has been implemented as an extension of Signavio process editor and tested using a real use case study from an industrial partner.
Dislocation Structures Formed inside Dislocation Channels of Rapid-Cooled and Tensile-Deformed Aluminum Single Crystals (2021)

Dislocation structures inside the cleared dislocation channels in rapid-cooled and tensile-deformed aluminum single crystals were investigated by using transmission electron microscope (TEM). The present study especially focused on the dislocation structures at their early formation stage. In their very beginning stage, arrays of prismatic dislocation loops of the primary slip system were essentially formed elongating along [1 2 1] direction and each prismatic loop stacked to [1 0 1]. With the progress of plastic deformation, the number of the prismatic loops composing the array increased and produced tangled structures with dislocations of the primary coplanar slip system. The tangled structures may act as strong obstacles against the following primary dislocations and become a triggering factor for the creation of the cell structure.
Synthesis of Hesperidin Glycosides by Cyclodextrin Glucanotransferase and Stabilization of the Natural Pigments. (1995)

An improved method for the synthesis of hesperidin glycosides was developed using both β-cyclodextrin (β-CD) and α-rhamnosidase treatments. The reaction, which contained 0.5% (8.2mM) hesperidin as an acceptor, 5% soluble starch as a donor and 2 units/ml of cyclodextrin glucanotransferase (CGTase) from an alkalophilic Bacillus species was incubated at 40°C and pH 10 for 16h, was used as the standard reaction. During the transglycosylation reaction, both β-CD and an alkaline pH were very effective for solubilizing hesperidin, and the amount of hesperidin glycosides formed by CGTase with 5% β-CD as a donor at pH 10 was about 50 times greater than the amount formed with soluble starch at pH 5. During the purification steps, α-rhamnosidase hydrolyzed the unreacted hesperidin into lower molecular weight and more hydrophobic compounds (hesperetin-7-glucoside), but it did not hydrolyze the hesperidin glycosides. Therefore, hesperidin glycosides were easily separated from the unreacted hesperidin using Sephadex LH-20. Various kinds of natural pigments were stabilized against ultraviolet radiation using the prepared hesperidin glycosides.
Robust Crop and Weed Segmentation under Uncontrolled Outdoor Illumination (2011)

An image processing algorithm for detecting individual weeds was developed and evaluated. Weed detection processes included were normalized excessive green conversion, statistical threshold value estimation, adaptive image segmentation, median filter, morphological feature calculation and Artificial Neural Network (ANN). The developed algorithm was validated for its ability to identify and detect weeds and crop plants under uncontrolled outdoor illuminations. A machine vision implementing field robot captured field images under outdoor illuminations and the image processing algorithm automatically processed them without manual adjustment. The errors of the algorithm, when processing 666 field images, ranged from 2.1 to 2.9%. The ANN correctly detected 72.6% of crop plants from the identified plants, and considered the rest as weeds. However, the ANN identification rates for crop plants were improved up to 95.1% by addressing the error sources in the algorithm. The developed weed detection and image processing algorithm provides a novel method to identify plants against soil background under the uncontrolled outdoor illuminations, and to differentiate weeds from crop plants. Thus, the proposed new machine vision and processing algorithm may be useful for outdoor applications including plant specific direct applications (PSDA).
The Cutoff Wavelengths of Composite Waveguides (Correspondence) (1961)

When electromagnetic waves propagate in waveguides of nonsimple cross section, no exact solution can be obtained by the conventional method of solving the wave equation by separation of variables. In such cases approximations are available such as perturbation methods, variational methods, etc.
Efeito do silício nas concentrações de lignina e de açúcares em bainhas de folhas de arroz infectadas por Rhizoctonia solani (2013)

A queima das bainhas, causada pelo fungo Rhizoctonia solani Kühn, é uma das mais importantes doenças que afetam a produção de arroz no mundo. Este trabalho teve como objetivo verificar o efeito do silício (Si) nas concentrações de lignina solúvel e insolúvel e de açúcares totais em bainhas de folhas de arroz infectadas por R. solani. Plantas de arroz dos cultivares BR-Irga-409 e Labelle foram cultivadas em solução nutritiva sem (0 mM) ou com (2 mM) Si. A concentração de Si nas bainhas das folhas das plantas dos cultivares BR-Irga-409 e Labelle supridas com Si aumentou em 77% e 84%, respectivamente, em relação às plantas não supridas com Si. O comprimento relativo da lesão de queima das bainhas foi significativamente menor nas bainhas das plantas supridas com Si em relação às bainhas das plantas não supridas com esse elemento. Não houve efeito do Si e nem da inoculação com R. solani nas concentrações de mananas, galactanas, arabinanas, xilanas, glucanas e de açúcares totais nas bainhas das plantas dos dois cultivares. Para as plantas dos dois cultivares supridas com Si, a concentração de açúcares totais foi menor quando comparada com a dos dois cultivares na ausência de Si. Não houve variação na concentração de lignina insolúvel, solúvel e total entre os cultivares. As concentrações de lignina insolúvel e total foram maiores nas plantas supridas com Si, independentemente da inoculação com R. solani. Em conclusão, plantas de arroz supridas com Si foram mais resistentes à queima das bainhas devido a uma maior lignificação dos tecidos das bainhas e menor concentração de açúcares totais.