gebhart/patrepeval huggingface dataset:
Safety and clinical activity of combination treatment with regorafenib and milciclib in liver transplant patients with hepatocellular carcinoma recurrence. (2020)

e16634 Background: Recurrence of hepatocellular carcinoma after liver transplant (LT-HCC), affects ~40% of patients. As LT-HCC drastically limits therapeutic options, combination of drugs with different mechanism of actions might be an attractive approach. Primary objective of this MiHRCO (Milciclib and Half Regorafenib CO-administration) protocol (87/2019/COMP/MiHRCO) is to evaluate safety and clinical activity of combination of Regorafenib (a tyrosine kinase inhibitor with higher clinical activity in aggressive HCC) with Milciclib (a pan cyclin dependent kinase inhibitor with clinical activities in refractory solid malignancy patients and HCC) in LT-HCC patients. Methods: Seven patients with LT-HCC are enrolled to date. Regorafenib administered at half the prescribed dose (80mg/day) for 3 weeks followed by 1 week Off and milciclib at 100 mg daily for 4 day On/3 day Off. Patients were maintained on this combination regimen until disease progression and/or unacceptable side effects. Primary endpoint was safety and secondary endpoints included progression free survival, time to progression, and clinical benefit rate. Results: This single-arm, single-center operative protocol in LT-HCC patients with extra-hepatic metastasis, not eligible to first line therapy with sorafenib (Todesca P. et al. Hepatology; doi: 10.1002/hep.30588), is currently ongoing. The combination treatment is well-tolerated with manageable toxicities (mostly related with regorafenib), i.e. moderate diarrhea, slight increase of hypertension in previously hypertensive patients and moderate hand and foot syndrome. Patients continuing with therapy are currently in 2 to 10 months of treatment period. All patients are exhibiting stable disease with reduced clinical symptoms. The mean AFP (□-fetoprotein) level (1310±200 ng/ml) at enrollment was reduced by 20% with in the first month of therapy. Importantly, AFP levels in 2 patients, treated for longer period, were reduced by 50%. Conclusions: Regorafenib and milciclib combination was well-tolerated. Most patients showed disease stabilization along with reduction in AFP levels within the first month of therapy. The encouraging clinical activity in difficult-to-treat patients with LT-HCC warrants continuation of this protocol and further evaluation in a larger controlled study. Clinical trial information: 87/2019/COMP/MiHRCO .
Normal concentrations of essential and toxic elements in pregnant baboons and fetuses (Papio species) (2004)

Heavy metals are essential for the normal progression of maternal and fetal tissue growth and metabolism in pregnancy. Considerable data have been collected for concentrations of various elements in pregnant women, but no comprehensive evaluation of element concentrations in any non-human primate model has been performed. Baboons were studied at the second half of pregnancy. Forty essential and toxic element concentrations were analyzed by absorption spectrophotometry in paired maternal and fetal blood samples; hair and nail samples in pregnant baboons; in placenta, amniotic fluid; and fetal femur, lymph nodes, and liver. Concentrations demonstrated an excellent correlation with concentrations reported in late human pregnancy. Twenty-four elements were below detectable limits in various specimens. We conclude that the pregnant baboon offers unique opportunities to study both normal maternal, fetal, and placental physiology as well as the environmental toxicology of these elements. This information and the ability to use the pregnant baboon as a model is important because essential and toxic elements are key components of the diet as well as major products of manufacturing processes within our industrialized society.
Methodology for teaching synthetic aperture sonar theory and applications to undergraduate physics and oceanography majors (2015)

Undergraduate senior level physics majors taking Acoustics and oceanography majors taking Underwater Acoustics and Sonar learn about transmitting and receiving arrays (in one unit of their course) and do laboratory experiments to support and enhance the theoretical developments. However, there is a need to expose the students to a detailed unit on synthetic aperture sonar (SAS) while research at USNA is in progress and a teaching laboratory workstation is being developed. This paper communicates the teaching strategy on the topics describing: (a) how a strip-mapped SAS system works, (b) how matched-filtering relates to pulsed compression for a linearly modulated (LFM) pulsed chirp, (c) how synthetic aperture resolution is vastly improved over a conventional acoustic array, (d) how Fourier analysis is used in SAS, and (e) how a data set of N echoes can be used within a back-projection algorithm to obtain a two dimensional reflectivity image of an area (sea floor). Key points are (1) theory with visualizations to convey the teaching material to seniors in a two week period of time, (2) computer simulations, (3) classroom demonstrations in a water tank or in air, and (4) student involvement in a mini-research project using the computers and demonstration apparatus.
Immunization status of preschool children in a teaching practice. (1985)

Of preschool children registered at a university family medicine centre, 82% were found to be adequately immunized. A review of patient charts, however, showed that 31% contained immunization information that was difficult to interpret; extensive home follow-up was required to confirm immunization data. Special emphasis must be placed on producing accurate, easily retrievable chart information. Practices where nurses had a major role in infant care had better immunization records. Given that immunization is now a requirement for school admission in Ontario, the cost and feasibility of a recall system of child immunization should be explored.
Keramische Membranen und Hohlfasern (2006)

Keramische Membranen Einleitung Historie der keramischen Membranen Aufbau keramischer Membranen Poröse keramische Träger (Supporte) Rohrförmige poröse keramische Träger Platten- und scheibenförmige poröse keramische Träger Membranen Makro- und mesoporöse Membranen Mikroporöse Membranen Dichte Membranen Module Rohrmodule Plattenmodule Rotationsfilter Trends Kapillaren und Hohlfasern Kompositmembranen Mikrofabrikation Literatur Keramische Hohlfasern Einführung Markt Membrangeometrien Forschungs- und Entwicklungsaktivitäten Angrenzende Forschungs- und Entwicklungsaktivitäten Hohlfaserherstellung Lyocell-/Alceruverfahren Polysulfonverfahren Spinnprozess und Hohlfasergeometrie Formgebung Trocknen Sintern Charakterisierung Morphologie und Geometrie Biegebruchspannung Vibrationsbeständigkeit Berstdruck Wasserpermeation Beschichtung Modultechnik Schleuderpotten und Standpotten Literatur
Non-Deterministic Oracles for Unrestricted Non-Projective Transition-Based Dependency Parsing (2015)

We study non-deterministic oracles for training non-projective beam search parsers with swap transitions. We map out the spurious ambiguities of the transition system and present two non-deterministic oracles as well as a static oracle that minimizes the number of swaps. An evaluation on 10 treebanks reveals that the difference between static and non-deterministic oracles is generally insignificant for beam search parsers but that non-deterministic oracles can improve the accuracy of greedy parsers that use swap transitions.
Is visual recognition entirely impenetrable? (1999)

Early vision provides general information about the environment that can be used for motor control or navigation and more specialized information that can be used for object recognition. The general information is likely to be insensitive to cognitive factors, but this may not be entirely true for the information used in model-based recognition.
Synchronized Activation of Brain Waves by Singing Bowl Beating Sounds (2021)

Abstract This study aims to verify if the beating sound of a singing bowl synchronizes and activates brain waves. The singing bowl sound used in this experiment strongly beats at the frequency of 6.68 Hz, while it decays exponentially and lasts for about 50 sec. Brain waves were measured for 5 min at the F3 and F4 region of the 17 subjects who heard the beating singing bowl sounds. Experimental results showed that the increases (up to ~ 251 %) in the spectral magnitudes of the brain waves were dominant at the beat frequency, compared to those of any other clinical brain wave frequency bands. The observed synchronized activation of the brain wave at the beating sound frequency supports that the singing bowl sound may effectively facilitate meditation and relaxation, considering that the beat frequency belongs to theta waves which increases in the relaxed meditation state.
HSR in the Northeast: What Next? (2015)

This article continues a series on very high-speed rail (VHSR) and high-speed rail (HSR) across the United States. In this installment, the author considers matters of feasibility and complexity involved with implementing HSR on the Northeast Corridor (NEC) and describes the newly initiated New Jersey High Speed Rail Improvement Project (NJHSIP). The Concept of Operations (CONOPS), program requirements and program scope of the NJHSIP are detailed.
Neutrophils in Cystic Fibrosis Display a Distinct Gene Expression Pattern (2008)

We compared gene expression in blood neutrophils (polymorphonuclear leukocytes, or PMNs) collected from healthy subjects with those of cystic fibrosis (CF) patients devoid of bacterial colonization. Macroarray analysis of 1050 genes revealed upregulation of 62 genes and downregulation expression of 27 genes in CF blood PMNs. Among upregulated genes were those coding for vitronectin, some chemokines (particularly CCL17 and CCL18), some interleukin (IL) receptors (IL-3, IL-8, IL-10, IL-12), all three colony-stimulating factors (G-, M-, GM-CSF), numerous genes coding for molecules involved in signal transduction, and a few genes under the control of gamma-interferon. In contrast, none of the genes coding for adhesion molecules were modulated. The upregulation of six genes in CF PMNs (coding for thrombospondin-1, G-CSF, CXCL10, CCL17, IKKvarepsilon, IL-10Ra) was further confirmed by qPCR. In addition, the increased presence of G-CSF, CCL17, and CXCL10 was confirmed by ELISA in supernatants of neutrophils from CF patients. When comparison was performed between blood and airway PMNs of CF patients, there was a limited difference in terms of gene expression. Only the mRNA expression of amphiregulin and tumor necrosis factor (TNF) receptor p55 were significantly higher in airway PMNs. The presence of amphiregulin was confirmed by ELISA in the sputum of CF patients, suggesting for the first time a role of amphiregulin in cystic fibrosis. Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells.
Towards More Trustable Log Files for Digital Forensics by Means of &#147;Trusted Computing&#148; (2010)

Trustable log data is essential in digital forensic investigations in order to allow reliable reconstruction of events. Existing solutions do not provide adequate protection, exposing the log-producing application to software-based attacks. In this paper we provide a solution based on Trusted Computing using a Trusted Platform Module (TPM) and AMD’s Secure Virtual Machine technology (SVM). While current solutions only protect against manipulation of existing logs, we go one step further by establishing hardware-based trust in the log producing application. Our solution ensures confidentiality, integrity and non-repudiation during creation, storage and transmission of log data.
Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis (2017)

The success of marker-based approaches for dissecting haematopoiesis in mouse and human is reliant on the presence of well-defined cell surface markers specific for diverse progenitor populations. An inherent problem with this approach is that the presence of specific cell surface markers does not directly reflect the transcriptional state of a cell. Here, we used a marker-free approach to computationally reconstruct the blood lineage tree in zebrafish and order cells along their differentiation trajectory, based on their global transcriptional differences. Within the population of transcriptionally similar stem and progenitor cells, our analysis reveals considerable cell-to-cell differences in their probability to transition to another committed state. Once fate decision is executed, the suppression of transcription of ribosomal genes and upregulation of lineage-specific factors coordinately controls lineage differentiation. Evolutionary analysis further demonstrates that this haematopoietic programme is highly conserved between zebrafish and higher vertebrates.
Pragmatic design of nanoscaleimulti-gate CMOS (2005)

Three-dimensional numerical device simulations are done to gain physical insights on multi-gate FinFETs, which portend the infeasibility of nanoscale triple-gate CMOS, and process/physics-based device/circuit simulations are done to check the concept of pragmatic nanoscale double-gate CMOS design, showing encouraging performance projections near the end of the SIA 2003 ITRS (2003).
Low acuity paediatric emergency visits under single-payer universal health insurance in Taiwan, 2000–2015: a population-based repeated cross-sectional design (2021)

Despite a comprehensive coverage of emergency care and low cost-sharing obligations under a single-payer universal health insurance programme in Taiwan, no significant increase in PED utilisation for LA conditions was observed between 2000 and 2015. Taiwan's experience may serve as an important reference for countries considering healthcare system reforms.
Testing of small connective tissue specimens for the determination of the mechanical behaviour of atherosclerotic plaques (1993)

The tearing of the cap of atheromatous plaques is the commonest cause of thrombosis in human coronary arteries. It has been proposed that tearing arises because of structural weakening of the cap's connective tissue around the tear. To test this hypothesis we compared the mechanical properties of the intact edges of torn plaque caps and unbroken caps. Owing to limitations in plaque size, a purpose-built tensometer was developed to study stress-strain relationships of the small connective tissue specimens. The design of the tensometer is reported and was shown to detect accurately, minor differences in connective tissues and to generate complete stress-curves with computer-assisted image analysis.
<title>Modeling of newborn EEG data for seizure detection</title> (1995)

Seizures are often the first sign of neurological disease or dysfunction in the human newborn. Their clinical manifestation however, is often subtle, which tends to hinder their diagnosis. This represents an undesireable situation since the failure to quickly and accurately diagnose seizure can lead to long term brain injury or even death. In this paper, the problem of automatic seizure detection in the newborn based on the electroencephalogram (EEG) is considered. It is shown that good detection performance of electrographic seizure, which is the manifestation of seizure within the EEG, is possible using a new approach which is based on a model for the generation of the EEG. This model is derived from the histology and biophysics of a localized portion of the brain and is thus physically motivated. The model for EEG seizure is first presented along with an estimator for the model parameters. Then a seizure detection scheme based on the model parameter estimates is suggested. The method is then used to detect seizure in both simulated and real newborn EEG data. This approach gives superior performance over conventional classification approaches which rely on training data to produce observable test statistics. This is because, in general, trained classifiers are particularly susceptible to the extreme variability of the EEG over time as well as from patient to patient.
The Most Holy Body and Blood of Christ (2014)

Parish Priest: Rt Rev Mgr Peter O’Reilly, PP, VG 1 Darling Street Phone 02866322627 Curates: Rev David Donnelly, CC Rev Raymond Donnelly, CC Assistant Priest: Rev Joseph McVeigh, Lisbellaw 07511652146 Priest on Duty: Fr Raymond Donnelly 028 66322075 St Paul’s Missal Readings p287 Roman Missal Readings p816 First Reading: Deuteronomy 8:2-3.14-16 He fed you with manna which neither you nor your fathers had known. Second Reading: Corinthians 10:16-17 That there is only one loaf means that, though there are many of us, we form a single body. Gospel: John 6:51-58 My flesh is real food and my blood is real drink. MASSES FOR THE COMING WEEK Sat 21st June (Vigil 6.00pm)(Month’s Mind) Carmel Cox, Riverside Sun 22nd June(Lisbellaw) James O’Doherty, Belmore Street (Next Sunday:James & Susan Monaghan, Hillview Walk) (Second Reader: Aaron Magee Prayers of the Faithful: Kayla Swift) Mon 23rd June 12th Week in Ordinary Time 10.00am Frank Irvine, Corban Avenue 6.00pm Convent Private Intention Tue 24th June The Nativity of St John the Baptist 8.00am Convent Cooper family, Belfast 10.00am Gloria Spillane and Frank Irvine, Corban Avenue Wed 25th June 12th Week in Ordinary Time 8.00am Convent Daniel & Mary (Girlie) McCabe, and deceased members of McCabe family, Hillview Road 10.00am Francis Stewart, Old Rossorry Thu 26th June 12th Week in Ordinary Time 8.00am Convent James McKenna, Omagh 10.00am Vincent & Mary McDonagh, Derrygore Terrace Fri 27th June The Most Sacred Heart of Jesus 10.00am Davy (Sen) & Peggy Campbell and David Campbell (Jnr), Derrylester and Riverside 7.30pm (First Anniversary) Owen (Junior)McTeggart, Drumcor Hill; Murphy family, Queen Street and Creegan family, Forthill Road and Sheila McDonnell, Derrin Road Sat 28th June The Immaculate Heart of Mary 10.00am Rosaleen & Thomas Moohan, Drumcoo and Kilmacormick Avenue; Eileen Jones, College Gardens. Reflection The Kingdom of God is not rocket science. It is, in fact, simple enough for a child to grasp. Is that woman hungry? Feed her. Is that man isolated? Welcome him. Is that family in danger? Offer them protection. Are those elderly folk housebound? Visit them. If we don’t know what to do, it’s not that we haven’t been more carefully advised.
Quantum-Dot Single-Photon Sources for Entanglement Enhanced Interferometry (2017)

Multiphoton entangled states such as "N00N states" have attracted a lot of attention because of their possible application in high-precision, quantum enhanced phase determination. So far, N00N states have been generated in spontaneous parametric down-conversion processes and by mixing quantum and classical light on a beam splitter. Here, in contrast, we demonstrate superresolving phase measurements based on two-photon N00N states generated by quantum dot single-photon sources making use of the Hong-Ou-Mandel effect on a beam splitter. By means of pulsed resonance fluorescence of a charged exciton state, we achieve, in postselection, a quantum enhanced improvement of the precision in phase uncertainty, higher than prescribed by the standard quantum limit. An analytical description of the measurement scheme is provided, reflecting requirements, capability, and restraints of single-photon emitters in optical quantum metrology. Our results point toward the realization of a real-world quantum sensor in the near future.
Potential of shipborne GPS atmospheric delay data for prediction of Mediterranean intense weather events (2012)

Abstract High spatial and temporal variability of mesoscale moisture fields is still a challenge for quantitative precipitation forecast within numerical weather prediction (NWP) models especially over ocean regions where observations are lacking. This study presents the comparison between integrated water vapor over the Mediterranean Sea determined from shipborne GPS, the NWP ALADIN/Météo‐France model and MODIS retrieval during a 4‐month campaign (autumn 2008). While moisture prediction of the NWP remains accurate during most of the observation period, there are significant periods with offsets between GPS data and model predictions. We analyze such events and discuss the associated meteorological situation. Copyright © 2012 Royal Meteorological Society
Mediated Electrochemical Oxidation of Pollutants in Crude Oil Desalter Effluent (2017)

Wastewater samples from a crude oil desalting process were subjected to extensive physicochemical characterization and electrolysis to evaluate the two main reaction pathways, electrochemical incineration and mediated oxidation, that occur during an electrochemical oxidation process (EOP) with a boron-doped diamond (BDD) anode. The effects of the main operating variables (pH, current density, and ionic composition) on the oxidation of organic pollutants and the production of hydroxyl radicals (●OH) were evaluated via spectroelectrochemistry, quantification of the total organic carbon (TOC), and fluorescence spectroscopy. The predominance of each reaction pathway was evaluated using tert-butyl alcohol (50 mM) as a ●OH scavenger, the main oxidant species in electrochemical incineration. The results indicated that the action of ●OH was minimal compared to that of active chlorine species (ClO-, HClO, and Cl2), oxychlorine radicals (ClO●, ClO2●, Cl●, and HOCl●), and oxychlorine anion radicals (Cl2●-, and HOCl●-). Under the optimal operating conditions (pH 8.5, j = 100 mA cm-2file:///D:/SNT-Style/journal/xml/journal.html, and tr = 3 h), a 98.2% mineralization rate in terms of TOC was achieved. Mediated electrochemical oxidation was the predominant reaction pathway and was thus responsible for the high degradation efficiency obtained.
LASER ANGIOPLASTY SYSTEM USING CONTACT CERAMIC TIP (1989)

We have been developing laser angioplasty system using contact ceramic tip. In order to stabilize the required power for plaque ablation, ceramic coating tip was designed and developed by implanting metal at the point of the surface of ceramic tip, and the special endoscope with 7F size was designed and developed from the points of percutaneous approach and ceramic tip usage. The laser probe was designed to be separated at the part of laser fiber and able to be inserted from the top of the endoscope.The special endoscope and laser probe with ceramic coating tip were very useful for atheroma ablation inside the aorta of atherosclerotic rabbits under the visual field. The required power for plaque ablation with ceramic coating tip was 5-15W, and was able to be stabilized.
Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis (2012)

Patients with GD had a higher frequency of ASCA IgG than controls.
Obstacle detection by means of stereo feature matching (2014)

Automated obstacle detection is required in a number of applications. It is a challenging task because there is no prior knowledge about the appearance of ground, or the locations and appearance of obstacles in the scene. In this paper, an obstacle detection system based on matching the color edge features in stereo images is presented. The paper also presents an enhanced adaptive local-cross based stereo matching method used in the system. The system has been extensively evaluated. The result of evaluation allows the usage of system for automatic detection of moderately sized obstacles within a distance range of 2-15 meters with sufficient accuracy.