gebhart/patrepeval huggingface dataset:
Paired Hormone Response Elements Predict Caveolin-1 as a Glucocorticoid Target Gene (2010)

Glucocorticoids act in part via glucocorticoid receptor binding to hormone response elements (HREs), but their direct target genes in vivo are still largely unknown. We developed the criterion that genomic occurrence of paired HREs at an inter-HRE distance less than 200 bp predicts hormone responsiveness, based on synergy of multiple HREs, and HRE information from known target genes. This criterion predicts a substantial number of novel responsive genes, when applied to genomic regions 10 kb upstream of genes. Multiple-tissue in situ hybridization showed that mRNA expression of 6 out of 10 selected genes was induced in a tissue-specific manner in mice treated with a single dose of corticosterone, with the spleen being the most responsive organ. Caveolin-1 was strongly responsive in several organs, and the HRE pair in its upstream region showed increased occupancy by glucocorticoid receptor in response to corticosterone. Our approach allowed for discovery of novel tissue specific glucocorticoid target genes, which may exemplify responses underlying the permissive actions of glucocorticoids.
The influence of retinal image motion on the perceptual grouping of temporally asynchronous stimuli (2019)

Briefly presented stimuli can reveal the lower limit of retinal-based perceptual stabilization mechanisms. This is demonstrated in perceptual grouping of temporally asynchronous stimuli, in which alternate row or column elements of a regular grid are presented over two successive display frames with an imperceptible temporal offset. The grouping phenomenon results from a subtle shift between alternate grid elements due to incomplete compensation of small, fixational eye movements occurring between the two presentation frames. This suggests that larger retinal shifts should amplify the introduced shifts between alternate grid elements and improve grouping performance. However, large shifts are necessarily absent in small eye movements. Furthermore, shifts follow a random walk, making the relationship between shift magnitude and performance difficult to explore systematically. Here, we established a systematic relationship between retinal image motion and perceptual grouping by presenting alternate grid elements (untracked) during smooth pursuit of known velocities. Our results show grouping performance to improve in direct proportion to pursuit velocity. Any potential compensation by extraretinal signals (e.g., efference copy) does not seem to occur.
Hippocampal Magnetic Resonance Imaging Abnormalities in Transient Global Amnesia (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
An overview of routing optimization for internet traffic engineering (2008)

Traffic engineering is an important mechanism for Internet network providers seeking to optimize network performance and traffic delivery. Routing optimization plays a key role in traffic engineering, finding efficient routes so as to achieve the desired network performance. In this survey we review Internet traffic engineering from the perspective of routing optimization. A taxonomy of routing algorithms in the literature is provided, dating from the advent of the TE concept in the late 1990s. We classify the algorithms into multiple dimensions: unicast/multicast, intra-/inter- domain, IP-/MPLS-based and offline/online TE schemes. In addition, we investigate some important traffic engineering issues, including robustness, TE interactions, and interoperability with overlay selfish routing. In addition to a review of existing solutions, we also point out some challenges in TE operation and important issues that are worthy of investigation in future research activities.
Improved controlled atmosphere high temperature scanning probe microscope (2013)

To locally access electrochemical active surfaces and interfaces in operando at the sub-micron scale at high temperatures in a reactive gas atmosphere is of great importance to understand the basic mechanisms in new functional materials, for instance, for energy technologies, such as solid oxide fuel cells and electrolyzer cells. Here, we report on advanced improvements of our original controlled atmosphere high temperature scanning probe microscope, CAHT-SPM. The new microscope can employ a broad range of the scanning probe techniques including tapping mode, scanning tunneling microscopy, scanning tunneling spectroscopy, conductive atomic force microscopy, and Kelvin probe force microscopy. The temperature of the sample can be as high as 850 °C. Both reducing and oxidizing gases such as oxygen, hydrogen, and nitrogen can be added in the sample chamber and the oxygen partial pressure (pO2) is monitored by an oxygen sensor. We present here some examples of its capabilities demonstrated by high temperature topography with simultaneously ac electrical conductance measurements during atmosphere changes, electrochemical impedance spectroscopy at various temperatures, and measurements of the surface potential. The improved CAHT-SPM, therefore, holds a great potential for local sub-micron analysis of high-temperature and gas induced changes of a wide range of materials.
Automatic annotation placement for interactive maps (2013)

Situation maps play an important role in planning and decision making in emergency response centers. Important information such as operating units or hazards is usually shown on these maps. Arranging the huge amount of in-formation can be challenging for operators, as this information should always be visible while not occluding im-portant regions of the underlying geographic map. As large interactive whiteboards are increasingly replacing tradition-al analog maps, new ways to assist with arranging information can be provided. In this paper, we present a new approach for placing annotations automatically on top of a map. For finding the optimal placement, our metrics are based on geographic features, on the users' sketched input, and on the annotations geometry itself. Moreover, we also added additional features to minimize occlusions for multiple annotations. First results were highly promising and showed that our approach improves input performance while keeping an optimal view of the map.
Estimating Soil Moisture from SAR Interferometry with Closure Phases (2019)

Since soil moisture influences the differential interferometric synthetic aperture radar phase, it would be advantageous to be able to use InSAR to estimate the moisture. Unfortunately, it hasn't yet been demonstrated how to accomplish this in a precise and robust manner. Two major problems exist: firstly the relationship between moisture and phase variations is not yet well understood for a variety of ground covers. Secondly, various terms contribute to the interferometric phase and the soil moisture one is mostly one of the smallest, meaning that it is difficult to separate it from the other contributions and provide a reliable estimation. To address the second problem we use triplet of interferograms, canceling out all phase terms other than soil moisture. Closure phases, the triplet's product, depend on soil moisture variations with a non-linear ambiguous relationship. We show that its inversion is feasible once the ambiguity is solved. We use ALOS-2 and UAVSAR data to estimate soil moisture using a simple physical model.
Characterization of Brazilian floral honey produced in the states of Santa Catarina and São Paulo using quantitative nuclear magnetic resonance (qNMR) spectroscopy (2023)

This study applied qNMR spectroscopy and chemometrics to metabolically profile polyfloral honey samples collected in southeastern (São Paulo - SP) and southern (Santa Catarina - SC) Brazil, over the 2019-2020 and 2020-2021 harvest seasons. Both 1D and 2D NMR experiments were carried out to identify and quantify metabolites, followed by descriptive statistical analysis, heatmap, and principal component analysis (PCA), considering geographic and botanical origins. Twenty-one metabolites were detected, encompassing carbohydrates, amino acids, organic acids, ketones, alcohols, esters, and alkaloids. The heatmap and the PCA allowed for distinguishing the geographical and botanical origin. Regarding the botanical origin, three clusters were detected, i.e., Hovenia dulcis (SC), Citrus spp. (SP), and Eucalyptus spp. (SC and SP). The analytical approach proved to be effective for determining the geographic and botanical origins of Brazilian polyfloral honey, even though the country has a huge floral diversity and, accordingly, different types of honey.
ChemInform Abstract: Synthesis of 8‐Methoxy‐1‐methyl‐1H‐benzo[de][1,6]naphthyridin‐9‐ol (Isoaaptamine) and Analogues. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrodynamic radioactivity detector for microparticles (1989)

A new technique for the measurement of the radioactive decay of single microparticles has been demonstrated. Although the experiments were made with droplets of order 20 μm in diameter, microparticles in the range 0.1–100 μm can be accommodated. An electrodynamic balance and combination light-scattering photometer were used to measure the charge-loss rate and size of a charged microsphere suspended in a laser beam by superposed ac and dc electrical fields. The charged particle undergoes charge loss in the partially ionized gas atmosphere which results from radioactive decay of 14C-tagged compounds, and the rate of charge loss is proportional to the rate of decay here. The charge on a particle was determined by measuring the dc voltage necessary to stably suspend the particle against gravity while simultaneously determining the droplet size by light-scattering techniques. The parameters which affect the operation of the electrodynamic balance as a radioactivity detector are examined, and the limits of its sensitivity are explored. Radioactivity levels as low as 120 pCi have been measured, and it appears that by reducing the background contamination inside our balance activity levels on the order of 10 pCi can be detected. This new technique has application in the measurement of activity levels and source discrimination of natural and man-made aerosols and smokes and is also useful for studies involving specifically labeled radio-chemical probes.
Application of Tripodal Linker Units to Immobilized Rhodium Complex Catalysts for Asymmetric Hydrogenation (2011)

Abstract The tripodal linker unit with one bromopropyl group and three anchoring silicon atoms was used to immobilize a chiral phosphine–rhodium complex catalyst on an ordered mesoporous silica support. The rhodium and phosphorus leaching levels into the reaction solution after asymmetric hydrogenation were lower for this catalyst than for immobilized catalysts prepared using conventional triethoxysilane.
HOBAN project - Development of radiation-tolerant fiber-based temperature and strain monitoring sensors for nuclear industry (2017)

International audience
A New Twist to Myopathy of Critical Illness (1999)

Professor; Department of Anesthesiology; Massachusetts General Hospital; Harvard Medical School; Boston, Massachusetts 02114 (Martyn)Professor; Neurosciences Group; Institute of Molecular Medicine; John Radcliffe Hospital; University of Oxford; Oxford OX3 9DS, United Kingdom (Vincent)This Editorial View accompanies the following article: Tsukagoshi H, Morita T, Takahashi K, Kunimoto F, Goto F: Cecal ligation and puncture peritonitis model shows decreased nicotinic acetylcholine receptor numbers in rat muscle: Immunopathologic mechanisms? Anesthesiology 1999; 91:448–60.SEPSIS, with its associated complications, is a leading cause of death in intensive care units, with a mortality rate exceeding 40%. [1] An important untoward effect of such a critical illness is muscle wasting and muscle weakness, resulting in ventilator dependence with increasing morbidity and mortality rates. [2] The origin of these functional changes can be broadly classified as neural, neuromuscular (junctional), and/or muscular, [3,4] and these critically ill patients, particularly of the
State as a Service : Towards Stateful Cloud Services (2012)

Cloud ERP or Enterprise Resource Planning (ERP) as a Cloud Service delivers value by reducing initial and long term operating costs since infrastructure, platform and (certain) application management tasks are delegated to a specialist provider. Questions present at intersection of the ERP challenge landscape and the Cloud Computing opportunity horizon include characterization of Cloud friendly ERP modules and adaptation of stateful (on-premises ERP) components to a stateless platform. Contributions of this thesis work include the R.A.I.N. Cloud fitness criteria that encompasses Responsiveness, Availability, I/O and Native support aspects of Cloud Services. More importantly, the State abstraction, a reliable and elastic state management framework employing Autonomic Computing and Redo Recovery constructs is introduced. Construction of abstraction properties, namely, affinity aware state preservation and recovery consider Cloud strengths of scaling out and reliability as well as peculiarities of Cloud billing model. Proof-of-concept implementation of State as a Service has been comprehensively detailed and evaluated advocating infrastructure layer support of the kind and associated tooling.
Nucleation and Oriented Growth of Aromatic Crystals on Friction-Transferred Poly(tetrafluoroethylene) Layers (1997)

The oriented growth of p-nitroaniline and hydroquinone deposited from the vapor phase on monooriented thin films of poly(tetrafluoroethylene) (PTFE) prepared by friction transfer is investigated by grazing incidence X-ray diffraction and polarized FTIR spectroscopy. Due to the formation of two-dimensional hydrogen-bonded networks, both aromatic compounds crystallize with a layered structure. p-Nitroaniline is found to contact the (100)PTFE surface with its (101)PNA crystallographic plane which is parallel to the hydrogen-bonded sheet. A similar PTFE/hydrogen-bonded sheet interface was never observed for γ-hydroquinone crystals vacuum deposited under similar experimental conditions. In fact, hydroquinone orients on PTFE with a (110)HYD or (11̄0)HYD contact plane. Reconstruction of the PTFE substrate at the substrate/deposit interface is invoked as a tentative explanation of the difference in orientational behavior of these two organic compounds.
Bio‐Templated Chiral Zeolitic Imidazolate Framework for Enantioselective Chemoresistive Sensing (2023)

Abstract Chiral metal–organic frameworks (MOFs) have gained rising attention as ordered nanoporous materials for enantiomer separations, chiral catalysis, and sensing. Among those, chiral MOFs are generally obtained through complex synthetic routes by using a limited choice of reactive chiral organic precursors as the primary linkers or auxiliary ligands. Here, we report a template‐controlled synthesis of chiral MOFs from achiral precursors grown on chiral nematic cellulose‐derived nanostructured bio‐templates. We demonstrate that chiral MOFs, specifically, zeolitic imidazolate framework (ZIF), unc ‐[Zn(2‐MeIm) 2 , 2‐MeIm=2‐methylimidazole], can be grown from regular precursors within nanoporous organized chiral nematic nanocelluloses via directed assembly on twisted bundles of cellulose nanocrystals. The template‐grown chiral ZIF possesses tetragonal crystal structure with chiral space group of P 4 1 , which is different from traditional cubic crystal structure of I ‐43 m for freely grown conventional ZIF‐8. The uniaxially compressed dimensions of the unit cell of templated ZIF and crystalline dimensions are signatures of this structure. We observe that the templated chiral ZIF can facilitate the enantiotropic sensing. It shows enantioselective recognition and chiral sensing abilities with a low limit of detection of 39 μM and the corresponding limit of chiral detection of 300 μM for representative chiral amino acid, D‐ and L‐ alanine.
On dependence estimation using correlated failure time data from case-control family studies (1999)

Correlated failure time data arise routinely in case-control family studies. To measure the dependence between bivariate failure times, a cross ratio, i.e. conditional hazard ratio, function has been used. Many approaches, ranging from estimating equations to likelihood score equations, have been proposed for the estimation of parameters in the cross ratio function from prospective family data. However, the adaptation of these approaches to case-control family data appears too complicated and computationally intensive to be practical. In this paper, a connection is established between the cross-ratio function and the relative risk function in a stratified proportional hazards model, leading to the development of a set of partial-likelihood-based estimating equations. A simulation study is conducted to evaluate the performance of this estimation procedure, and two datasets are analysed to illustrate this method.
Elemental composition of the lunar surface: Analysis of gamma ray spectroscopy data from Lunar Prospector (2006)

Gamma ray spectroscopy data acquired by Lunar Prospector are used to determine global maps of the elemental composition of the lunar surface. Maps of the abundance of major oxides, MgO, Al 2 O 3 , SiO 2 , CaO, TiO 2 , and FeO, and trace incompatible elements, K and Th, are presented along with their geochemical interpretation. Linear spectral mixing is used to model the observed gamma ray spectrum for each map pixel. The spectral shape for each elemental constituent is determined by a Monte Carlo radiation transport calculation. Linearization of the mixing model is accomplished by scaling the spectral shapes with lunar surface parameters determined by neutron spectroscopy, including the number density of neutrons slowing down within the surface and the effective atomic mass of the surface materials. The association of the highlands with the feldspathic lunar meteorites is used to calibrate the mixing model and to determine backgrounds. A linear least squares approach is used to unmix measured spectra to determine the composition of each map pixel. The present analysis uses new gamma ray production cross sections for neutron interactions, resulting in improved accuracy compared to results previously submitted to the Planetary Data System. Systematic variations in lunar composition determined by the spectral unmixing analysis are compared with the lunar soil sample and meteorite collections. Significant results include improved accuracy for the abundance of Th and K in the highlands; identification of large regions, including western Procellarum, that are not well represented by the sample collection; and the association of relatively high concentrations of Mg with KREEP‐rich regions on the lunar nearside, which may have implications for the concept of an early magma ocean.
MultiMedia Digital Conferencing: A Web-enabled multimedia teleconferencing system (1998)

The convergence of the telecommunication and information technologies brings a real revolution to the communications world and hence in the way that people interact and communicate with each other. With the development of the World Wide Web technology for browsing and navigating through the Internet, complemented by the global telecommunication network, new, easy-to-use tools are being developed to simplify and enhance collaboration among people. In this paper, we describe the MultiMedia Digital Conferencing (MMDC) prototype system, which is a Web-enabled teleconferencing system. The MMDC server allows heterogeneous clients to use the Internet and the telecommunication network in order to establish and participate in data and/or audio conferences through the use of a variety of audio systems and computing platforms.
Epiplexus cells in the embryos of the turtle, Trionyx sinensis. (1985)

The epiplexus cells in the embryos of the turtle, Trionyx sinensis were examined in scanning and transmission electron microscopy. Although the cells showed diverse morphological forms, the majority of the cells however had a stellate cell body each with 3-5 radiating long processes with secondary processes terminating on the ventricular surface of the choroid epithelial cells. The cell body was relatively smooth. Occasional epiplexus cells displayed blebs on their cell bodies and processes. In the transmission electron microscope, the nucleus contained coarse chromatin clumps. The cytoplasm was endowed with large lysosomal bodies. Based on these observations, it is suggested the epiplexus cells in the turtle embryos are phagocytic even though most of them probably are at the resting stage.
How cells respond to environmental cues – insights from bio-functionalized substrates (2016)

Biomimetic materials have long been the (he)art of bioengineering. They usually aim at mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells. The past decade has witnessed a considerable amount of progress in soft lithography, bio-inspired micro-fabrication and biochemistry, allowing the design of sophisticated and physiologically relevant micro- and nano-environments. These systems now provide an exquisite toolbox with which we can control a large set of physicochemical environmental parameters that determine cell behavior. Bio-functionalized surfaces have evolved from simple protein-coated solid surfaces or cellular extracts into nano-textured 3D surfaces with controlled rheological and topographical properties. The mechanobiological molecular processes by which cells interact and sense their environment can now be unambiguously understood down to the single-molecule level. This Commentary highlights recent successful examples where bio-functionalized substrates have contributed in raising and answering new questions in the area of extracellular matrix sensing by cells, cell-cell adhesion and cell migration. The use, the availability, the impact and the challenges of such approaches in the field of biology are discussed.
A Novel and Practical One Step Synthesis of 5,6-Dihydro -3-Phenyl-4H-Pyrrolo (1,2-b) Pyrazole (Withasomnine) (1985)

Abstract Withasomnine (2), the only bicyclic pyrazole alkaloid found thus far in Nature, has been prepared, in one step, by cyclo-addition of Ph-C=C-H and the strained bicyclic meso-ionic system 1, derived from L-proline. The cyclo-addition also gives the novel, un-natural isomer 3.