gebhart/patrepeval huggingface dataset:
The mechanism of priming of pop-out: Stored short-term memory representation or perceptual level weight changes? (2010)

In pop-out search, repetition of an attention-driving feature facilitates search on the current trial. This priming of pop-out is known to be due to a decaying memory trace of the attention-focus features; however there is no explicit consensus of the locus of the memory trace that influences the current trial. We investigated two possible mechanisms of priming of pop-out: a trace of the previous feature stored in visual short-term memory (VSTM) and a trace along perceptual level features. Experiment 1 replicated the priming of pop-out effect with a task of discriminating the gap location of odd-colored Landolt C shaped objects. In Experiment 2, a VSTM load was added to the pop-out search; occupying VSTM did not interfere with the priming of pop-out effect. In Experiment 3, we intervened an irrelevant task (discriminating the orientation of a pointing object) between pop-out search trials. Results showed that even though the intervening task was not related to the current pop-out search task, the color of the object for intervening task influenced on the current pop-out search task. These results suggest that the priming of pop-out might not be due to a memory trace in VSTM, but rather might be due to the perceptual level feature weight changes for attended objects.
ChemInform Abstract: Synthesis of Methyl (E)‐4‐[2‐(2,3‐Dihydro‐3‐methyl‐3‐hydroxymethylbenzo [b]thien‐5‐yl)‐1‐propenyl]benzoate (IXa), Methyl (E)‐4‐[2‐(2,3‐Dihydro‐3‐methyl‐3‐hydroxymethyl‐5‐benzofuranyl) ‐1‐propenyl]benzoate (IXb), and Methyl (E)‐4‐[2‐(2,3‐Dihydro‐3,3‐dimethyl‐5‐benzofuranyl) ‐3‐hydroxy‐1‐propenyl]benzoate (XI) as Potential Metabolites of Selected Heteroarotinoids with Fused Five‐Membered Rings. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Extending High-Level Synthesis for Task-Parallel Programs (2021)

C/C++/OpenCL-based high-level synthesis (HLS) becomes more and more popular for field-programmable gate array (FPGA) accelerators in many application domains in recent years, thanks to its competitive quality of result (QoR) and short development cycle compared with the traditional register-transfer level (RTL) design approach. Yet, limited by the sequential C semantics, it remains challenging to adopt the same highly productive high-level programming approach in many other application domains, where coarse-grained tasks run in parallel and communicate with each other at a fine-grained level. While current HLS tools support task-parallel programs, the productivity is greatly limited in the code development, correctness verification, and QoR tuning cycles, due to the poor programmability, restricted software simulation, and slow code generation, respectively. Such limited productivity often defeats the purpose of HLS and hinder programmers from adopting HLS for task-parallel FPGA accelerators.
Phase I dose-escalation study of docetaxel/predisone and fractionated 177Lu-J591 for metastatic castrate-resistant prostate cancer (metCRPC). (2010)

TPS247 Background: Nearly all prostate cancers express prostate specific membrane antigen (PSMA), with limited expression in other organs, making it an ideal therapeutic target. Monoclonal antibody J591 binds the extracellular domain of cells expressing PSMA with optimal affinity and is effectively internalized, with excellent targeting of metastatic sites when radiolabeled (Liu Clin Cancer Res 1997 & 1998, Milowsky JCO 2004, Bander JCO 2005). 177Lu is a radionuclide with gamma and short-range beta emission. A phase II trial of single-dose 177Lu-J591 radioimmunotherapy (RIT) in pts with metCRPC demonstrated efficacy with acceptable toxicity and an apparent dose-response relationship (Tagawa et al, ASCO 2008). It appears that dose-fractionation of 177Lu-J591 allows higher cumulative doses with less myelosuppression (Tagawa et al, submitted ASCO 2010). Docetaxel, which is standard chemotherapy for metCRPC, is a known radiosensitizer. We hypothesize that this combination will have superior clinical efficacy compared to either agent alone. The objective is to determine toxicity profile and maximal tolerated dose (MTD) of 177Lu-J591 plus docetaxel prior to the initiation of a phase II clinical trial. Methods: This is a multi-institutional phase I trial for men with progressive metCRPC that are docetaxel naive or have demonstrated prior docetaxel sensitivity. Docetaxel 75 mg/m2 is given every 3 weeks with prednisone 10 mg daily. Cohorts of 3-6 men receive escalated doses of fractionated 177Lu-J591 (20 mCi/m2 × 2, escalated in 5 mCi/m2 increments, to maximum of 45 mCi/m2 × 2). The initial dose of 177Lu-J591 is administered 2-3 days prior to cycle 3 of docetaxel to take advantage of initial chemotherapy debulking and to optimize radiosensitization (DeNardo Cancer 1997). Cycle 4 of docetaxel is administered upon adequate hematologic recovery. The primary endpoints are determination of MTD and toxicity profile. Secondary endpoints include response rate and survival. Exploratory objectives include the analysis of PSMA expression in circulating tumor cells and PSMA-based nuclear scans as biomarkers of response and/or toxicity with anti-PSMA-based RIT. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration sanofi-aventis
1PT103 Mechanism of ATP binding and channel activation in P2X receptors(The 50th Annual Meeting of the Biophysical Society of Japan) (2012)

JapanGeneral IncorporatedAssociation approximately divided into 1 1 independent re]axational modes, about ha]f or five ofwhich wjth larger amplitudes contribute to 76% ofthe whole fluctuation.(3) Each of these major modes originates in correlated fluctuations of the hydration states of severa] specific PGs.Their relaxation times range widely from 1O ps to several tens of ns.lpTolo di!rem"veavmlcdi6tru-uyMmco*mmnf Hydration study of oligophosphates by dielectric relaxation spectroscopy
Natural Products for Material Protection: Inhibition of Mild Steel Corrosion by Date Palm Seed Extracts in Acidic Media (2013)

The corrosion inhibition effect of date palm (Phoenix dactylifera) seed extracts for mild steel in 1 M HCl and 0.5 M H2SO4 solutions was investigated by weight loss and electrochemical methods. The inhibition efficiency increased with an increase in the extract concentration and decreased with an increase in the temperature. Extract concentrations of 2.5 and 1.5 g L–1 gave maximum inhibition efficiencies in 1 M HCl and 0.5 M H2SO4, respectively. The immersion time was also found to influence the corrosion inhibition effect in both acidic media. Polarization curves indicate that the extract functions as a mixed inhibitor, affecting both the anodic and cathodic partial reactions of the corrosion process. Adsorption of the extract onto a mild steel surface followed the Langmuir adsorption isotherm. The mechanism of physical adsorption has been proposed based on the trend of the inhibition efficiency with temperature. The date palm seed extract is a better corrosion inhibitor for mild steel in HCl than in a H2SO4 solution.
Electric field profiles around an electrical probe immersed in a plasma (2007)

Laser-induced fluorescence-dip spectroscopy was used to measure the spatial distribution of electric fields around a biased cylindrical probe in an argon rf discharge. Two-dimensional maps of the field profiles were obtained around the probe as functions of argon pressure, discharge power, probe bias, and phase of the rf cycle. Analysis of the radial dependence of the electric fields indicated that the ion density decreased in the vicinity of the probe for all cases, contrary to the orbit motion limited regime typically employed for Langmuir probe analysis. We also observed perturbation of the plasma by the presence of the probe that extended many times the measurable length scale of the sheath (∼5Δxsheath) into the plasma around the probe. Electric field distributions were also measured as functions of distance from the plasma sheath boundary. Coupling between the bounding sheath fields of the plasma and those formed around the biased probe was observed, even at distances greater than length scales of either sheath.
Treatment of behavioural symptoms and dementia in Parkinson's disease (2005)

Behavioural symptoms such as anxiety, depression and psychosis are common in Parkinson's disease (PD), and dementia occurs in about 90% of the patients. These symptoms can be more disabling than the motor dysfunction and they negatively impact quality of life, increase caregiver distress and are more frequently associated with nursing home placement. Depression can be treated with counselling and pharmacotherapy. Tricyclic antidepressants or selective serotonin reuptake inhibitors are widely used, but there is still need for controlled clinical trials. Management of psychosis in PD is complex and includes elimination of identifiable risk factors, reduction of polypharmacy and administration of atypical neuroleptics, which can alleviate psychotic symptoms without worsening motor functions. Clozapine is the best documented atypical neuroleptic shown to be effective against psychosis in PD patients. Cholinesterase inhibitors may prove additional benefit in psychotic PD patients. Recent evidence from small double-blind and open-label trials suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD.
A CASE OF LAPAROSCOPIC CHOLECYSTECTOMY FOR A WOMAN IN THE 27TH WEEK OF GESTATION (1998)

An experience with a case of laparoscopic cholecystectomy, with the abdominal wall suspended under hypobaric pneumoperitoneum, in a 27-year-old woman is reported on. While observing the clinical course of cholelithiasis, the patient became having repeated right hypochondralgia on the eighth week of gestation, and an increase in hepatic enzyme was noted in the 22nd week of gestation. The patient was considered a possible candidate for operation because of repeated subsequent attacks of colic. Laparoscopic cholecystectomy was conducted in the 27th week of gestation. Using general anesthesia, surgery could be performed under a comparatively favorable field of vision by lifting the area directly above the navel and the right hypochondriac arch and with the additional use of hypobaric pneumoperitoneum at 4-8mmHg, as necessary. The postoperative course was uneventful, resulting in a safe delivery. We think that laparoscopic cholecystectomy is very beneficial procedure for pregnent women.
Spatiotemporal control of nanooptical excitations (2010)

The most general investigation and exploitation of light-induced processes require simultaneous control over spatial and temporal properties of the electromagnetic field on a femtosecond time and nanometer length scale. Based on the combination of polarization pulse shaping and time-resolved two-photon photoemission electron microscopy, we demonstrate such control over nanoscale spatial and ultrafast temporal degrees of freedom of an electromagnetic excitation in the vicinity of a nanostructure. The time-resolved cross-correlation measurement of the local photoemission yield reveals the switching of the nanolocalized optical near-field distribution with a lateral resolution well below the diffraction limit and a temporal resolution on the femtosecond time scale. In addition, successful adaptive spatiotemporal control demonstrates the flexibility of the method. This flexible simultaneous control of temporal and spatial properties of nanophotonic excitations opens new possibilities to tailor and optimize the light-matter interaction in spectroscopic methods as well as in nanophotonic applications.
Monomethylthio analogs of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane (1977)

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM).
Necroptosis in neurodegenerative diseases: a potential therapeutic target (2017)

Neurodegenerative diseases are a group of chronic progressive disorders characterized by neuronal loss. Necroptosis, a recently discovered form of programmed cell death, is a cell death mechanism that has necrosis-like morphological characteristics. Necroptosis activation relies on the receptor-interacting protein (RIP) homology interaction motif (RHIM). A variety of RHIM-containing proteins transduce necroptotic signals from the cell trigger to the cell death mediators RIP3 and mixed lineage kinase domain-like protein (MLKL). RIP1 plays a particularly important and complex role in necroptotic cell death regulation ranging from cell death activation to inhibition, and these functions are often cell type and context dependent. Increasing evidence suggests that necroptosis plays an important role in the pathogenesis of neurodegenerative diseases. Moreover, small molecules such as necrostatin-1 are thought inhibit necroptotic signaling pathway. Understanding the precise mechanisms underlying necroptosis and its interactions with other cell death pathways in neurodegenerative diseases could provide significant therapeutic insights. The present review is aimed at summarizing the molecular mechanisms of necroptosis and highlighting the emerging evidence on necroptosis as a major driver of neuron cell death in neurodegenerative diseases.
The Rise Of TikTok: A Case Study Of The New Social Media Giant (2022)

The COVID-19-induced lockdowns of 2020 caused millions of people to make greater use of social media platforms, including the TikTok mobile app. With over 800 million users globally and more than $1 billion in revenues in 2020, TikTok has emerged as a major player in the world of social media content. This case study explores how TikTok can improve its positioning as a mobile app for businesses and consumers. It also analyzes TikTok as a method of disruptive marketing. Additionally, this study evaluates how TikTok became a significant platform for social influencers. By serving its customers' needs for curated and concise video content, TikTok has created digital marketing opportunities, including branding, reach, sponsorships, and influencer capabilities. This study has significance for researchers and practitioners and broadens contemporary assumptions about strategic planning for social media platforms.
A simple design method of pole placement for linear time-varying multi-input systems (2009)

In this paper, a simple design method of pole placement for linear multi-input time-varying systems is proposed. The pole placement feedback gain matrix is calculated directly from the system parameters, by finding the new output signal such that the relative degree from the input to this output is equal to the system degree. In the design procedure, any change of variable to the standard form is not used, so, the design process is very simple.
Detection of polymeric IgA in sera from patients with IgA nephropathy determined by thin-layer gel filtration. (1984)

Polymeric IgA in sera was determined by thin-layer gel filtration in patients with IgA nephropathy, other glomerular diseases, IgA myeloma and healthy adults to determine whether serum IgA is composed of a monomeric and/or larger polymers in these patients. The levels of IgA in sera were also quantitated by laser nephelometer in these patients. Eleven patients with IgA nephropathy (Berger's disease), six patients with other glomerular diseases, three patients with IgA myeloma and four healthy adults were examined. It was shown that the polymerized IgA in sera from patients with IgA nephropathy was significantly higher than that in sera from patients with other glomerular diseases and healthy adults. Levels of IgA in sera from patients with IgA nephropathy are significantly higher than that in sera from patients with other glomerular diseases and healthy adults. These findings suggest that an increase in serum IgA from patients with IgA nephropathy may be mainly due to an increase in polymers rather than the monomer of IgA.
Water-Bloom Treatment by Underwater Pulsed Streamer-Like Discharges (2007)

Summary form only given. Cyanobacteria blooms (or water blooms) occurs on the surface of water bodies frequently and extensively due to eutrophia of the water. Those have caused more and more serious environmental problems world-wide. Here, we report the effects of pulsed streamer-like discharges on <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M. aeruginosa </i> cells, which are one genus of cyanobacteria and form water blooms easily. The point to cylinder electrode, having a stainless needle with 30 mum in tip diameter and a stainless cylinder with 30 cm in diameter, is used as a discharge reactor, where 2mus-160kV pulsed voltage is applied. A pulsed streamer-like discharges are obtained in the water filled with cyanobacteria cells. After applying single discharge, the colonies of the cells sink to the bottom of the discharge chamber. From the TEM observation of cells, it can be found that the discharge mainly collapses the intracellular structure - gas vesicles without the damage of the other part of structure. It is concluded that the gas vesicles of the cells collapse and cells sink to the bottom of the water bodies by applying pulsed streamer-like discharges to water bodies with cyanobacteria cells before the water bloom occurs. Therefore the cells multiplication and the water bloom formation can be prevented.
Physical immobilization characteristics of a hybridoma in a glass bead packed‐bed reactor (1989)

One of the important considerations in design of large scale cell culture systems is the fragility or shear-sensitivity of animal cells. The engineering approach to overcome this problem has been to entrap the cells in various physical structures, such as hollow fibers, microencapsulation, fluidized sponge beads, and others. Packed-bed configurations not only can retain cells in the inter-particle voids, but could potentially provide the needed shear protection to animal cells. Even though packed-bed systems have been successfully used for bacterial and yeast strains, only a few reports exist on its use for cultivating surface independent animal
Assessing Stagnation Conditions and Identifying Trends in Magnetized Liner Inertial Fusion (2019)

Magnetized Liner Inertial Fusion (MagLIF) is a magneto-inertial fusion concept, which is presently being studied on the Z Pulsed Power Facility. The concept utilizes an axial magnetic field and laser heating to produce fusion-relevant conditions at stagnation despite a peak magnetically driven implosion velocity of less than 100 km/s. Initial experiments demonstrated the viability of the concept but left open questions about the amount of laser energy coupled to the fuel and the role that mix played in the stagnation conditions. In this paper, simple methodologies for estimating the laser energy coupled to the fuel and determining the stagnation pressure and mix are presented. These tools enabled comparisons across many experiments to establish performance trends, as well as allow comparisons with 2-D magnetohydrodynamics simulations. The initial experiments were affected by low laser energy coupling (0.2-0.6 kJ), which resulted in reduced neutron yields (1-2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> ). In addition, all early experiments utilized mid-Z (aluminum) fuel-facing components. Mixing from these components had a significant impact on stagnation and increased with laser energy. Lower neutron yields (1-3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> ) were measured with higher laser coupling (0.8-1.2 kJ), which significantly deviated from the predicted scaling. When all fuel-facing components were made from a low-Z material (beryllium), neutron production increased (3.2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> ) and scaled as expected with laser energy; experimental yields were approximately 40% of simulated yields. In addition, roughly I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> yield scaling was observed in experiments, where the load current was varied from 16-18 MA. These results represent the first step in experimental demonstration of stagnation performance scaling with input parameters in MagLIF.
Molecular Markers for Tm-2 Alleles of Tomato Mosaic Virus Resistance in Tomato (2011)

Tomato mosaic virus (ToMV) is one of the most infectious virus diseases in tomato (Solanum lycopersicum L). The practical and effective method of controlling this disease is through genetic control by using major resistance genes. So far, three genes Tm-1, Tm-2 and Tm-22 conferring resistance to ToMV have been reported and utilized in tomato culti-var development. Marker assisted selection (MAS) has become very important and useful tool in selection of ToMV re-sistant tomato lines or hybrids. The objective of this research was to identify allele-specific PCR-based, cleaved ampli-fied polymorphic sequence (CAPS), and allele-derived single nucleotide polymorphism (SNP) markers for Tm-2 loci. Four allele-specific PCR-based markers were identified: one for Tm-2, one for Tm-22, and two for the susceptible allele tm-2. Three allele-derived CAPS markers were identified, which can identify and distinguish three alleles, tm-2, Tm-2 and Tm-22 in tomato germplasm. Three SNP markers were developed specific for Tm-2 locus. These markers will pro-vide breeders with a tool in selection of Tm-2 and Tm-22 resistance genes in tomato breeding program.
Topologically adaptable snakes (2002)

The paper presents a typologically adaptable snakes model for image segmentation and object representation. The model is embedded in the framework of domain subdivision using simplicial decomposition. This framework extends the geometric and topological adaptability of snakes while retaining all of the features of traditional snakes, such as user interaction, and overcoming many of the limitations of traditional snakes. By superposing a simplicial grid over the image domain and using this grid to iteratively reparameterize the deforming snakes model, the model is able to flow into complex shapes, even shapes with significant protrusions or branches, and to dynamically change topology as necessitated by the data. Snakes can be created and can split into multiple parts or seamlessly merge into other snakes. The model can also be easily converted to and from the traditional parametric snakes model representation. We apply a 2D model to various synthetic and real images in order to segment objects with complicated shapes and topologies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
2. Mécanismes de discrimination et processus de différenciation identitaire (1985)

Archined est l’archive ouverte institutionnelle et la base patrimoniale des publications, communications et autres travaux scientifiques produits par les chercheur.e.s, y compris les chercheur.e.s associé.e.s, et ingénieur.e.s de l’Ined.