gebhart/patrepeval huggingface dataset:
Blade health monitoring of gas turbine using online crack detection (2017)

Gas turbine engine blades are subjected to severe fatigue which is caused by complex in-service environment. In fact, blade crack is one of the costliest sources of damage in gas turbine. Detection of cracks of blades is important to ensure safe and reliable operation of gas turbine engine. A vibration-based damage-detection methodology is presented in this paper to monitor the health condition of gas turbine rotor blade. In order to simulation the real-time dynamic crack propagation of rotor blades, model analysis was performed using a finite element model to calculate the natural frequencies and mode shapes of gas turbine blade, the possible crack initiation location was determined, the natural frequencies and mode shapes changed as the crack growing, indicating the feasibility of the methodology to capture the dynamic health condition of blade on-line. Simulation results have indicated the capability of the methodology in evaluating the changes of blade vibration signals once damage is initiated of growing, and in consistently detecting cracks of damaged blade to monitor the health condition. Additionally, the results indicated that blade natural frequency decays slightly when crack propagating, providing the potential for reliable diagnosis of the gas turbine blades with crack fault, thus the implementation of blade health monitoring system will be the approach to achieve condition-based maintenance.
Spiegelsysteme streifenden Einfalls als abbildende Optiken für Röntgenstrahlen (1952)

Abstract Als Optiken zur Röntgenstrahlmikroskopie eignen sich Systeme von total‐reflektierenden Spiegeln, die bei Hebung der sphärischen Aberration für einen Achsenpunkt zugleich die Abbesche Sinusbedingung bis zu Aperturen 0,05 befriedigend erfüllen. Für die Lebenduntersuchung biologischer Objekte empfehlen sich Wellenlängen um 24 Å, die im Wasser wenig, aber in kohlenstoffhaltigen oder stickstoffhaltigen Stoffen stark absorbiert werden. Mit diesen weichen Strahlen ist eine Steigerung des Auflösungsvermögens gegenüber dem Lichtmikroskop um mindestens eine Größenordnung unter Verwendung der hier beschriebenen Optiken zu erwarten.
Determining the camera and light source location for a visual task (2003)

Techniques for calculating the three-dimensional region of acceptable locations for vision sensors and light sources are discussed. An integrated method to position both a camera and a light source based on the requirements of a given vision task is described. The method also selects the appropriate lens aperture. The proposed techniques require only a small amount of computation (approximately 1 minute of elapsed time on a time-shared VAX 8600). The proposed approach is illustrated with an example object and experimental results are described for that object.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing (2005)

Biofilms are at the root of many infections largely because they are much more antibiotic resistant than their planktonic counterparts. Antibiotics that target the biofilm phenotype are desperately needed, but there is still no standard method to assess biofilm drug susceptibility. Staphylococcus epidermidis ATCC 35984 biofilms treated with eight different approved antibiotics and five different experimental compounds were exposed to the oxidation reduction indicator Alamar blue for 60 min, and reduction relative to untreated controls was determined visually and spectrophotometrically. The minimum biofilm inhibitory concentration was defined as < or = 50% reduction and a purplish well 60 min after the addition of Alamar blue. All of the approved antibiotics had biofilm MICs (MBICs) of >512 microg/ml (most >4,096 microg/ml), and four of the experimental compounds had MBICs of < or = 128 microg/ml. The experimental aaptamine derivative hystatin 3 was used to correlate Alamar blue reduction with 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction and viable counts (CFU/ml) for S. epidermidis ATCC 35984, ATCC 12228, and two clinical isolates. For all four strains, Alamar blue results correlated well with XTT (r = 0.83 to 0.97) and with CFU/ml results (r = 0.85 to 0.94). Alamar blue's stability and lack of toxicity allowed CFU/ml to be determined from the same wells as Alamar blue absorbances. If the described method of microplate Alamar blue biofilm susceptibility testing, which is simple, reproducible, cost-effective, nontoxic, and amenable to high throughput, is applicable to other important biofilm forming species, it should greatly facilitate the discovery of biofilm specific agents.
Thalamus sends information about arousal but not valence to the amygdala (2022)

We conclude that the MGN-BLA projector population acts as both filter and transferer of information by relaying information about the salience of cues to the amygdala, but these signals are not valence-specified.
Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses (2011)

Highly cited biomarker studies often report larger effect estimates for postulated associations than are reported in subsequent meta-analyses evaluating the same associations.
Computer systems are dynamical systems (2009)

In this paper, we propose a nonlinear dynamics-based framework for modeling and analyzing computer systems. Working with this framework, we use a custom measurement infrastructure and delay-coordinate embedding to study the dynamics of these complex nonlinear systems. We find strong indications, from multiple corroborating methods, of low-dimensional dynamics in the performance of a simple program running on a popular Intel computer-including the first experimental evidence of chaotic dynamics in real computer hardware. We also find that the dynamics change completely when we run the same program on a different type of Intel computer, or when that program is changed slightly. This not only validates our framework; it also raises important issues about computer analysis and design. These engineered systems have grown so complex as to defy the analysis tools that are typically used by their designers: tools that assume linearity and stochasticity and essentially ignore dynamics. The ideas and methods developed by the nonlinear dynamics community, applied and interpreted in the context of the framework proposed here, are a much better way to study, understand, and design modern computer systems.
Generation of nanosecond and subnanosecond laser pulses by AlGaAs/GaAs laser-thyristor with narrow mesa stripe contact (2016)

Lasers-thyristors with a narrow (20 μm) mesa stripe contact have been studied. It was shown that the laser peak power reaches a value of 2.5 W in the long-pulse mode at a pulse width of 13 ns. It was demonstrated that generation of a controlled train of laser pulses with peak power of 1.6 W and width of 90 ps is possible in the short-pulse mode. The maximum value of the pulse repetition frequency was 470 kHz at the following working characteristics of the laser-thyristor: blocking voltage 5.8 V, control current pulse 25 mA. A number of specific features were observed in the short-pulse mode. It was found that the blocking voltage and amplitude of the control current pulse affect the lasing process. We observed that in short pulse mode the lasing spectra have a two-band structure and the lateral near field may degenerate into a single spot with size substantially smaller than the mesa stripe width. It was shown that the main reason for the observed specific features of lasing is the clearly pronounced effect of the spatial localization of the current.
Kinetics and identifiability of intramolecular two-state excited-state processes with added quencher: global compartmental analysis of the fluorescence decay surface (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and identifiability of intramolecular two-state excited-state processes with added quencher: global compartmental analysis of the fluorescence decay surfaceNoel Boens, Marcel Ameloot, Bart Hermans, Frans C. De Schryver, and Ronn AndriessenCite this: J. Phys. Chem. 1993, 97, 4, 799–808Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100106a003https://doi.org/10.1021/j100106a003research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Immunogenicity of a recombinant hemagglutinin neuraminidase-<i>Porcine rubulavirus</i> produced by <i>Escherichia coli</i> of <i>Porcine rubulavirus</i> gives protective immunity of litter after challenge (2022)

Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day-old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN-PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n=8), survived, respectively, showing milder PRV clinical signs. Our data indicate that rHN-PorPV candidate vaccine produced in Escherichia coli induces efficient humoral response in pregnant sows and that the maternally derived immunity provides high protection to suckling piglets against PRV lethal challenge.
Analysis of a new continuous-to-discrete-time operator for the approximation of fractional order systems (2016)

One of the methods for discrete-time approximation of fractional order systems consists in an indirect approach in which a continuous-time rational transfer function is firstly derived. Then, using different mapping techniques, the s plane transfer function is converted to the z plane. In this paper a new mapping technique is proposed. The tuning parameter of this continuous-to-discrete-time mapping operator balances the discrete-time approximation between the classical Euler and Tustin rules, ensuring an increased flexibility compared to these classical methods. An analysis of the effects of the changes in this parameter is given, along with some general guidelines for its proper selection. The authors show that for digital approximation of fractional order systems using the indirect approach, Tustin rule can lead to ringing and should be avoided. The inverse discrete-to-continuous time operator is also presented. Numerical examples are provided. The results show that high accuracy of approximation is obtained and that the proposed method can be considered as a suitable solution, compared to classical discretization methods (Tustin).
Correlation manipulating circuits for stochastic computing (2018)

Stochastic computing (SC) is an emerging computing technique that promises high density, low power, and error tolerant solutions. In SC, values are encoded as unary bitstreams and SC arithmetic circuits operate on one or more bitstreams. In many cases, the input bitstreams must be correlated or uncorrelated for SC arithmetic to produce accurate results. As a result, a key challenge for designing SC accelerators is manipulating the impact of correlation across SC operations. This paper presents and evaluates a set of novel correlation manipulating circuits to manage correlation in SC computation: a synchronizer, desynchronizer, and decorrelator. We then use these circuits to propose improved SC maximum, minimum, and saturating adder designs. Compared to existing correlation manipulation techniques, our circuits are more accurate and up to 3× more energy efficient. In the context of an image processing pipeline, these circuits can reduce the total energy consumption by up to 24%.
SenseCityVity: Mobile Crowdsourcing, Urban Awareness, and Collective Action in Mexico (2017)

This work describes SenseCityVity, an approach to engage and support youth in a city in Mexico as they investigate, document, and reflect upon urban problems through mobile crowdsourcing. SenseCityVity focused on the development of a mobile crowdsourcing platform; the deployment of the Urban Data Challenge, codesigned by the authors' research team and actors to collect geolocalized images, audio, and video; and the analysis, appropriation, and creative use of the collected data for community reflection and artistic creation. The approach integrates mobile technology and community practices involving a large population of young people for urban engagement. The collective action generated a new multimedia dataset that is rich in terms of content and is enabling a number of studies aimed at better understanding the urban landscape of cities in the Global South. This article is part of a special issue on smart cities.
Statistical Recoupling Prior to Significance Testing in Nuclear Magnetic Resonance Based Metabonomics (2009)

Significance testing is a crucial step in metabolic biomarker recovery from the metabolome-wide latent variables computed by multivariate statistical analysis. In this study we propose an algorithm based on the landscape of the covariance/correlation ratio of consecutive variables along the chemical shift axis to restore, prior to significance testing, the spectral dependency and recouple variables in clusters which correspond to physical, chemical, and biological entities: statistical recoupling of variables (SRV). Variables are associated into a series of clusters, which are then considered as individual objects for the control of the false discovery rate. Compared to classical procedures, it is found that SRV allows efficient recovery of statistically significant metabolic variables. The proposed SRV method when associated with the Benjamini-Yekutieli correction retains a low level of significant variables in the noise areas of the nuclear magnetic resonance (NMR) spectrum, close to that observed using the conservative Bonferroni correction (false positive rate), while also allowing successful identification of statistically significant metabolic NMR signals in cases where the classical procedures of Benjamini-Yekutieli and Benjamini-Hochberg (false discovery rate) fail. This procedure improves the interpretability of latent variables for metabolic biomarker recovery.
100 &#x00B5;A, 320 nT/vHz, 3-AXIS Lorentz force MEMS magnetometer (2015)

The work presents a module for earth magnetic field measurements based on four microelectromechanical devices: one out-of-plane and two in-plane differential Lorentz-force magnetometers, and a Tang resonator. The latter is used to provide the reference frequency in off-resonance operation, a way that enables the magnetometers to share the same Lorentz current, giving an intrinsic 3-fold consumption decrease. At the same time, using multiple-loop design, a 5-fold larger sensitivity and a 4-fold better resolution are obtained with respect to previous implementations that used the same process. The system operating bandwidth is electronically selectable up to 50 Hz.
ChemInform Abstract: SYNTHESIS OF 9‐N‐SUBSTITUTED AMINOMETHYLPHENANTHRENES (1977)

Abstract Die Aminomethylphenanthrene (III), deren biologische Aktivität untersucht werden soll, lassen sich durch Umsetzung der Chlormethylphenanthrene (I) mit äquimolaren Mengen der Amine (II) synthetisieren.
MicroRNAs, mRNAs, and Translation (2006)

MicroRNAs (miRNAs) comprise a large family of regulatory molecules that repress protein production from targeted mRNAs. Although it is now clear that miRNAs exert pervasive effects on gene expression in animal cells, the mechanism(s) by which they function remains poorly understood. We have analyzed the subcellular distribution of miRNAs in actively growing HeLa cells and find that the vast majority are associated with actively translating mRNAs in polysomes. We also find that a specific miRNA-regulated mRNA (KRAS) is polysome associated and that its translation is impaired, apparently at the level of elongation. These observations are discussed in light of our current understanding of mechanism of miRNA function.
Radioimmunoassay of tumor necrosis factor in serum. (1987)

We present a double-antibody radioimmunoassay for determination of the concentration of tumor necrosis factor (TNF) in serum. TNF in serum competes with a fixed amount of 125I-labeled TNF for the binding sites of specific rabbit antibodies. The bound TNF is precipitated with Sepharose-bound anti-rabbit IgG, then centrifuged, and the radioactivity of the pellets is counted. The detection limit of the assay is 7 ng/L (B0-3 SD). Bound radioactivity in the range of 10% to 90% of the B0 counts corresponds to TNF concentrations of 26 to 10,000 ng/L. Of 40 sera from healthy subjects, 21 (53%) contained TNF concentrations greater than 7 ng/L (range 8-40 ng/L). Some patients with parasitic or neoplastic disease and patients with septic shock had highly increased TNF values. Three of the 14 sera (21%) from patients with rheumatoid arthritis had TNF concentrations greater than 40 ng/L.
Diffusion‐Free Scaling in Rotating Spherical Rayleigh‐Bénard Convection (2021)

Direct numerical simulations are employed to reveal three distinctly different flow regions in rotating spherical Rayleigh-Bénard convection. In the high-latitude region <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>I</mml:mi></mml:math> vertical (parallel to the axis of rotation) convective columns are generated between the hot inner and the cold outer sphere. The mid-latitude region <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>I</mml:mi> <mml:mi>I</mml:mi></mml:math> is dominated by vertically aligned convective columns formed between the Northern and Southern hemispheres of the outer sphere. The diffusion-free scaling, which indicates bulk-dominated convection, originates from this mid-latitude region. In the equator region <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>I</mml:mi> <mml:mi>I</mml:mi> <mml:mi>I</mml:mi></mml:math> , the vortices are affected by the outer spherical boundary and are much shorter than in region <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>I</mml:mi> <mml:mi>I</mml:mi></mml:math> .
Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study (2014)

In this sub-group analysis of a large multicenter randomized trial, IIT did not appear to alter the day-90 neurological outcome or ICU morbidity in severe brain injured patients or ICU morbidity.
Slope seeking and application to compressor instability control (2004)

This work introduces slope seeking, a new idea for non-model based adaptive control. It involves driving the output of a plant to a value corresponding to a commanded slope of its reference-to-output map. To achieve this objective, we introduce a slope reference input into a sinusoidal perturbation-based extremum seeking scheme; derive a stability test for single parameter slope seeking, and then develop a systematic design algorithm based on standard linear SISO control methods to satisfy the stability test. We then extend the results to the multi variable case of gradient seeking. Finally, we illustrate near-optimal compressor operation under slope seeking feedback through a simulation study upon the well-known Moore-Greitzer model of compressor instability.
Molecular Architecture of the Mouse Nervous System (2018)

The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous system. We mapped cell types spatially and derived a hierarchical, data-driven taxonomy. Neurons were the most diverse and were grouped by developmental anatomical units and by the expression of neurotransmitters and neuropeptides. Neuronal diversity was driven by genes encoding cell identity, synaptic connectivity, neurotransmission, and membrane conductance. We discovered seven distinct, regionally restricted astrocyte types that obeyed developmental boundaries and correlated with the spatial distribution of key glutamate and glycine neurotransmitters. In contrast, oligodendrocytes showed a loss of regional identity followed by a secondary diversification. The resource presented here lays a solid foundation for understanding the molecular architecture of the mammalian nervous system and enables genetic manipulation of specific cell types.
mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control (2019)

U2 auxiliary factor 1 (U2AF1) functions in 3'-splice site selection during pre-mRNA processing. Alternative usage of duplicated tandem exons in U2AF1 produces two isoforms, U2AF1a and U2AF1b, but their functional differences are unappreciated due to their homology. Through integrative approaches of genome editing, customized-transcriptome profiling and crosslinking-mediated interactome analyses, we discovered that the expression of U2AF1 isoforms is controlled by mTOR and they exhibit a distinctive molecular profile for the splice site and protein interactomes. Mechanistic dissection of mutually exclusive alternative splicing events revealed that U2AF1 isoforms' inherent differential preferences of nucleotide sequences and their stoichiometry determine the 3'-splice site. Importantly, U2AF1a-driven transcriptomes feature alternative splicing events in the 5'-untranslated region (5'-UTR) that are favorable for translation. These findings unveil distinct roles of duplicated tandem exon-derived U2AF1 isoforms in the regulation of the transcriptome and suggest U2AF1a-driven 5'-UTR alternative splicing as a molecular mechanism of mTOR-regulated translational control.