gebhart/patrepeval huggingface dataset:
With a Grain of Salt: What Halite Has to Offer to Discussions on the Origin of Life (2006)

This experimental study investigated how the dynamics of the crystallization of the evaporite mineral halite could affect the accumulation and preservation of organic macromolecules present in the crystallizing solution. Halite was grown under controlled conditions in the presence of polymer nanoparticles that acted as an analog to protocellular material. Optical microscopy, atomic force microscopy, and laser scanning confocal fluorescence microscopy were used to trace the localization of the nanoparticles during and after growth of halite crystals. The present study revealed that the organic nanoparticles were not regularly incorporated within the halite, but were very concentrated on its surfaces. Their distribution was controlled dominantly by the morphologic surface features of the mineral rather than by specific molecular interactions with an atomic plane of the mineral. This means that the distribution of organic molecules was controlled by surfaces like those of halite's evaporitic growth forms. The experiments with halite also demonstrated that a mineral need not continuously incorporate organic molecules during its crystallization to preserve those molecules: After rejection by (non-incorporation into) the crystallizing halite, the organic nanoparticles increased in concentration in the evaporating brine. They ultimately either adsorbed in rectilinear patterns onto the hopper-enhanced surfaces and along discontinuities within the crystals, or they were encapsulated within fluid inclusions. Of additional importance in origin-of-life considerations is the fact that halite in the natural environment rapidly can change its role from that of a protective repository (in the absence of water) to that of a source of organic particles (as soon as water is present) when the mineral dissolves.
Per-Chunk Caching for Video Streaming from a Vehicular Cloud (2017)

Caching content at the edge of mobile networks is considered as a promising way to deal with the data tsunami. In addition to caching at fixed base stations or user devices, it has been recently proposed that an architecture with public or private transportation acting as mobile relays and caches might be a promising middle ground. In previous work, we have assumed users are streaming video files and have analyzed how many replicas of each video file to cache in such a vehicular fleet working towards minimizing the amount of bits per file downloaded from (expensive) infrastructure links. However, this work has been assuming that a vehicle will store the entire content, or none of it. In practice, later chunks have an inherent "delay tolerance" as there is more time to find them before they must be played out. What is more, numerous studies as well as everyday experience suggest that most files (e.g., YouTube) are not entirely watched. This makes the previous policies suboptimal, as fewer (or no) replicas could be allocated to late chunks of a file and more to the most popular chunks. In this work, we formulate an optimization problem to compute the optimal allocation per-chunk, to minimize the load on the cellular infrastructure, and we show that significant performance gains can be achieved compared to per-content allocation policies.
Asymmetric Fluorination of α‐Aryl Acetic Acid Derivatives with the Catalytic System NiCl2—Binap/R3SiOTf/2,6‐Lutidine. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal and molecular structures of complexes of two isomeric 18-membered tetraaza Macrocyclic ligands having the empirical formula [CuC20H40N4](ClO4)2. Effects of chelate ring size and double-bond placement on coordination geometry about copper(II) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structures of complexes of two isomeric 18-membered tetraaza Macrocyclic ligands having the empirical formula [CuC20H40N4](ClO4)2. Effects of chelate ring size and double-bond placement on coordination geometry about copper(II)James H. Timmons, Phil Rudolf, Arthur E. Martell, John W. L. Martin, and Abraham ClearfieldCite this: Inorg. Chem. 1980, 19, 8, 2331–2338Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ic50210a030https://doi.org/10.1021/ic50210a030research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Generalized dispersion properties of a four-layer thin-film waveguide (1987)

A general analytic expression is derived, which describes the dispersion properties of a four-layer thin-film optical waveguide. The formula describes the variation of the effective refractive index with respect to any physical parameter with which the refractive index of any layer or the thickness of the guiding layers may vary. Normalized parameters are used, and curves are presented which describe the contributions of the individual layers and waveguide geometry to the total dispersion. Uses of the formula are illustrated for the cases of temperature and wavelength dispersions. Results show that considerable control of the effective index of refraction is possible. Application to the control of chromatic dispersion in a thin-film Luneburg lens is also demonstrated.
CD8- and CD95/95L-Dependent Mechanisms of Resistance in Mice with Chronic Pulmonary Tuberculosis (2001)

The role of CD8 T lymphocytes in the immune response to Mycobacterium tuberculosis infection remains enigmatic, with persuasive reports of both cytolytic and noncytolytic (cytokine-mediated) responses to infection. To address the importance of the cytolytic mechanisms, mice with targeted disruptions for CD8 and perforin or with gene mutations in the CD95/ CD95L signaling pathway were exposed to pulmonary infection. All mice tested showed no differences in their ability to contain the growth of infection during the early phase of disease. As the chronic phase of the disease ensued, however, both CD8- and CD95/CD95L-deficient mice gradually lost their ability to limit bacterial growth. This was associated with a tendency toward pyogenic inflammation in the lung. This tendency was not seen in the perforin gene-disrupted mice. In CD8 gene-disrupted mice, the ability to generate interferon-gamma secreting T cells was unimpaired. Although these cells were capable of entering the lung they were unable to influence the increasing bacterial load in this organ.
Fluid Biomarkers of Pediatric Mild Traumatic Brain Injury: A Systematic Review (2020)

Public concern is growing about the short- and long-term effects of pediatric mild traumatic brain injury (mTBI). This concern is amplified because pediatric mTBI has the potential to go undiagnosed in acute care settings, placing children at increased risk for reinjury prior to complete recovery. The management of mTBI can be particularly challenging due to the lack of validated biomarkers that clinicians can use to objectively diagnose pediatric mTBI, predict risk for prolonged recovery, or demonstrate mTBI recovery. Fluid-based biomarkers have drawn increased attention as an objective measure to diagnose and manage pediatric mTBI, but investigations of promising biomarkers may pose unique challenges in pediatric populations. Our systematic review confirms the relative paucity of high-quality, clinically impactful diagnostic or prognostic fluid biomarker studies, on samples representing only a small fraction of pediatric mTBI. Ultimately, well-designed longitudinal studies across diverse points of care are needed to truly characterize the utility of fluid biomarkers of injury and recovery for the pediatric mTBI patient.
Observation of a Significant Excess ofπ0π0Events inBMeson Decays (2003)

We present a study of the decay B0-->pi(0)pi(0) based on a sample of 124 x 10(6) BB pairs recorded by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We observe 46+/-13+/-3 events, where the first error is statistical and the second is systematic, corresponding to a significance of 4.2 standard deviations including systematic uncertainties. We measure the branching fraction B(B0-->pi(0)pi(0))=(2.1+/-0.6+/-0.3)x10(-6), averaged over B0 and B(0) decays.
Effect of Zoe Temporary Restoration on Resin‐Dentin Bond Strength Using Different Adhesive Strategies (2007)

Although the prior use of eugenol-containing temporary restoration (IRM) affects the resin-dentin bond strength of the etch-and-rinse Single Bond, a more pronounced reduction on bond strength was observed for the two self-etch systems evaluated (iBond, Clearfil SE Bond). CLINICAL SIGNIFICANCE Eugenol-containing provisional restorations (IRM) should not be used prior to the placement of resin restorations bonded with the two-step etch-and-rinse Single Bond and the self-etch adhesives systems iBond and Clearfil SE Bond.
Design and Development of a Landfill Gas Combustion System for the Typhoon Gas Turbine (1996)

This paper presents design, initial combustion development testing and engine validation results of a combustion system which is capable of burning a medium CV landfill gas or conventional diesel oil in a 5MW gas turbine. Initial rig testing of the original combustion system burning a simulated medium CV gas revealed stability problems and inherently poor combustion efficiencies. A study of primary zone flow patterns and fuel placement led to the conclusion that the problems were due to axial injection of the gas. Subsequently a modified dual fuel injector was designed which relied on swirled instead of axial injection. The modified injector design also embodies a passive purge feature, which uses combustor wall pressure drop to feed air directly into the gas swirler passages. This prevents ingestion of harmful combustion products when running on diesel oil. Extensive rig testing demonstrated encouraging combustion efficiencies and emissions using 40% and 54% methane landfill gas compositions across a simulated engine load profile. Operation of the modified injector on diesel oil however, demonstrated a need for the incorporation of an anti-carbon feature. The effectiveness of this anti-carbon modification was verified as part of a ‘validation engine cycle’ simulating the actual engine operating procedure from light up to shutdown. Post test inspection revealed carbon deposition to be significantly reduced. Combustion efficiencies, emissions, traverse quality, metal temperatures, stability and noise were all found to be satisfactory.
AberrantKeap1methylation in breast cancer and association with clinicopathological features (2012)

Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein that mediates the ubiquitination/degradation of genes regulating cell survival and apoptosis under oxidative stress conditions. We determined methylation status of the KEAP1 promoter in 102 primary breast cancers, 14 pre-invasive lesions, 38 paired normal breast tissues and 6 normal breast from reductive mammoplasty by quantitative methylation specific PCR (QMSP). Aberrant promoter methylation was detected in 52 out of the 102 primary breast cancer cases (51%) and 10 out of 14 pre-invasive lesions (71%). No mutations of the KEAP1 gene were identified in the 20 breast cancer cases analyzed by fluorescence based direct sequencing. Methylation was more frequent in the subgroup of patients identified as ER positive-HER2 negative tumors (66.7%) as compared with triple-negative breast cancers (35%) (p = 0.05, Chi-square test). The impact of the interactions between Er, PgR, Her2 expression and KEAP1 methylation on mortality was investigated by RECPAM multivariable statistical analysis, identifying four prognostic classes at different mortality risks. Triple-negative breast cancer patients with KEAP1 methylation had higher mortality risk than patients without triple-negative breast cancer (HR = 14.73, 95%CI: 3.65-59.37). Both univariable and multivariable COX regressions analyses showed that KEAP1 methylation was associated with a better progression free survival in patients treated with epirubicin/cyclophosfamide and docetaxel as sequential chemotherapy (HR = 0.082; 95%CI: 0.007-0.934). These results indicate that aberrant promoter methylation of the KEAP1 gene is involved in breast cancerogenesis. In addition, identifying patients with KEAP1 epigenetic abnormalities may contribute to disease progression prediction in breast cancer patients.
Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma (2021)

To identify the gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) and laboratory findings that enable prediction of treatment response and disease-free survival (DFS) after the first session of drug eluting bead transarterial chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC). A total of 55 patients who underwent GA-enhanced MRI and DEB-TACE from January 2014 to December 2018 were included. All MRI features were reviewed by two radiologists. Treatment response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors. Univariate and multivariate logistic regression analyses were used to determine predictive factors of treatment response and DFS, respectively. A total of 27 patients (49.1%) achieved complete response (CR) after one session of treatment. There were no significant differences between the two groups in terms of clinical and laboratory characteristics. Heterogeneous signal intensity in the hepatobiliary phase (HBP) was the only independent predictor of non-CR (odds ratio, 4.807; p = 0.048). Recurrent HCC was detected in 19 patients (70.4%) after CR. In the multivariate analysis, elevated serum alpha-fetoprotein (AFP) level (≥ 30 ng/mL) was the only significant parameter associated with DFS (hazard ratio, 2.916; p = 0.040). This preliminary study demonstrated that heterogeneous signal intensity in the HBP and high serum AFP were useful predictive factors for poor treatment response and short DFS after DEB-TACE, respectively.
Abstract 4843: TP53-stabilization with APR-246 enhances antitumor effects of immune checkpoint blockade in preclinical models (2019)

An emerging body of literature suggests a role of TP53 pathway in antitumor immunity including antigen presentation and T cell proliferation. Stabilization of TP53 could therefore alter the immune tumor microenvironment, enabling the immune system to target tumor cells more effectively. APR-246 covalently modifies the core domain of cellular TP53 through the alkylation of thiol groups, leading to reactivation of endogenous TP53 activity. To further study the effect of APR-246 on antitumor immunity we used a B16 pre-clinical melanoma mouse model. In vitro treatment of B16 cells with APR-246 caused intracellular accumulation of TP53, leading to increased apoptosis. However, treatment of B16-melanoma bearing mice with APR-246 monotherapy did not result in a statistically significant change in tumor growth or survival. Analyses of the tumor immune microenvironment showed increased immune potentiating M1 polarized tumor-associated macrophages, and Granzyme B activity in CD8+ T cells, suggesting enhanced anti-tumor immunity. Concomitantly, there was increased PD-L1 expression in the macrophages, PD-1 expression on CD8+ T cells, and Foxp3+ Tregs in tumors from APR-246 treated animals. Therefore, we decided to combine anti-PD-1 antibody (RMP-1) to APR-246 treatment in tumor-bearing mice. The combination led to a significant delay in tumor growth (P < 0.001) and improved survival of B16-bearing mice compared to anti-PD1 or APR-246 monotherapies (P < 0.01). Improved responses were also seen in MC38 colorectal cancer-bearing mice (P < 0.01). The anti-tumor effects of APR-246 and anti-PD1 were T cell dependent and abrogated in hosts lacking T cells. Analyses of the tumor immune microenvironment showed that the combination decreases proliferation but increases cytolytic activity of CD8+ T cells compared to anti-PD1 alone. We next studied the effect of combining APR-246 with anti-PD1+ anti-CTLA-4 (9B9). Combination of APR-246 with dual immune checkpoint blockade using anti-PD1 and anti-CTLA-4 showed further tumor growth inhibition in B16-melanoma compared to monotherapies (P < 0.001). Our studies support a role for restoring TP53 in the tumor microenvironment and provide evidence that reactivation of TP53 by APR-246 can enhance anti-tumor immune responses and inhibit tumor growth in preclinical models.Citation Format: Arnab Ghosh, Judith Michel, Lauren Dong, Nathan Suek, Hong Zhong, Sadna Budhu, Olivier de Henau, Jedd Wolchok, Taha Merghoub. TP53-stabilization with APR-246 enhances antitumor effects of immune checkpoint blockade in preclinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4843.
Effect of Curing Temperature on Corrosion Resistance of Aluminum Sheet Coated with Epoxy Resin Using Electrodeposition Process (1994)

Effect of curing temperature on corrosion resistance of aluminum sheet coated with epoxy resin using electrodeposition process has been investigated. Corrosion test revealed that weight loss of aluminum sheet in 1wt% NaCl solution (pH3.0, 301K) decreased with an increase of curing temperature. It was found that water absorption of electrodeposition film was independent of an increase of curing temperature. Water permeability and adhesion between film and aluminum sheet, however, increased with an increase of curing temperature. (Water permeability)×(adhesion)-1 was correlated well with corrosion resistance. Corrosion behavior of aluminum sheet coated with epoxy resin is discussed in terms of physical properties of electrodeposition film against water and related with adhesion.
The joint relationship of conscientiousness and ability with performance: test of the interaction hypothesis (1999)

This study investigated whether conscientiousness and ability interact in the prediction of job performance. Although few studies have directly addressed this issue, there is limited evidence that ability moderates the relationship between conscientiousness and job performance. Specifically, it has been reported that the relationship of conscientiousness to performance is positive for high ability and near zero or negative for low ability. Results in the present study provided no support for the interaction of GMA and conscientiousness. Moderated hierarchical regression analyses for three independent samples of participants (146 managers in sample 1, 103 sales representatives in sample 2, and 121 managers in sample 3), showed that the interaction did not account for unique variance in the prediction of supervisory ratings of job performance beyond that accounted for by GMA and conscientiousness. These findings indicate that ability does not moderate the relationship of conscientiousness to job performance. Practical implications for employee selection practices, and theoretical implications for models of job performance, are discussed.
ChemInform Abstract: Mass Transport and Chemical Demixing of Y‐Ba‐Cu‐O Compounds During Sintering in Temperature Gradients. (1988)

Abstract A thin cyclindrical powder compact (3 mm diameter, 20 mm length) of YBa 2 Cu 3 O 6 +x (x not determined) is sintered in a static temp. gradient of 25 °C/mm (the hot end at 940 °C) in air for 12 h and subsequently analyzed by SEM and EDAX.
Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology (2017)

Particles of cowpea mosaic virus (CPMV) have enjoyed considerable success as nanoparticles. The development of a system for producing empty virus-like particles (eVLPs) of the virus, which are non-infectious and have the potential to be loaded with heterologous material, has increased the number of possible applications for CPMV-based particles. However, for this potential to be realised, it was essential to demonstrate that eVLPs were accurate surrogates for natural virus particles, and this information was provided by high-resolution cryo-EM studies of eVLPs. This demonstration has enabled the approaches developed for the production of modified particles developed with natural CPMV particles to be applied to eVLPs. Furthermore, a combination of cryo-EM and mutagenic studies allowed the development of particles which are permeable but which could still assemble efficiently. These particles were shown to be loadable with cobalt, indicating that they can, indeed, be used as nano-containers.
Editorial: Mechanisms of Lymphocyte Exclusion in the Tumor Microenvironment (2022)

Solid tumors which have an abundance of lymphocytes penetrating the tumor fields, so-called immune inflamed tumors, often have a prognostic benefit over non-immune inflamed tumors, which generally respond less to treatment. Non-inflamed tumors can be classified as immune deserts, with no lymphocytes present within the tumor microenvironment (TME), or immune excluded, where lymphocytes are unable to penetrate the tumor core from the stromal areas. This Research Topic includes 14 articles that explore the mechanisms that drive lymphocyte exclusion and provide insight how to attract the lymphocytes into the tumor nests.