gebhart/patrepeval huggingface dataset:
Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities for mucocutaneous bleeding disorders (2023)

Improving our understanding of the basic biology of MCB, large cohort longitudinal natural history studies, collaboration, and creative approaches to novel therapeutics will be important in maximizing the benefit of future research for the entire MCB community.
Studies on the Mechanism of Replication of Adenovirus DNA II. The Nature of Single-Stranded DNA in Replicative Intermediates (1973)

Replicative intermediates of adenovirus type 5 DNA contain large stretches of single-stranded DNA. We have shown that this single-stranded DNA is mainly of parental origin, whereas all new DNA synthesized during one round of replication has a double-stranded structure. Hybridization experiments of the single-stranded DNA with isolated complementary strands of adenovirus type 5 DNA showed that this DNA hybridized only with the viral L-strand (the strand with the lower equilibrium density in alkaline CsCl) indicating that it represents the viral H-strand. This observation implies that replication always starts from one and the same molecular end. Electron microscopy of partially denatured Y-shaped intermediates confirmed this and showed that replication started from the molecular right end (the end richest in A-T base pairs). In conclusion, we have shown that replication of adenovirus type 5 DNA starts at the molecular right end, displacing the parental H-strand.
AXIOM: A Hardware-Software Platform for Cyber Physical Systems (2016)

Cyber-Physical Systems (CPSs) are widely necessary for many applications that require interactions with the humans and the physical environment. A CPS integrates a set of hardware-software components to distribute, execute and manage its operations. The AXIOM project (Agile, eXtensible, fast I/O Module) aims at developing a hardware-software platform for CPS such that i) it can use an easy parallel programming model and ii) it can easily scale-up the performance by adding multiple boards (e.g., 1 to 10 boards can run in parallel). AXIOM supports task-based programming model based on OmpSs and leverage a high-speed, inexpensive communication interface called AXIOM-Link. Another key aspect is that the board provides programmable logic (FPGA) to accelerate portions of an application. We are using smart video surveillance, and smart home living applications to drive our design.
The Outside Vapor Deposition Method of Fabricating Optical Waveguide Fibers (1982)

The outside vapor deposition (OVD) process for fabricating high performance glass optical waveguide fibers is reviewed. Starting metal halide chemicals, porous soot preform fabrication, sintering steps, and fiber drawing are discussed. Preform target size and its effect in obtaining deposition rates to 4 g/min is presented. Data comparisons of OVD fiber performance with other vapor deposited techniques are presented for attenuation, hydroxyl content, and strength (0.7 GPa / M/sup 2/ for 49.5 km of fiber). Single-mode fiber results including excellent geometric concentricity are also discussed.
Longitudinal-shock-wave compression of Nd2Fe14B high-energy hard ferromagnet: The pressure-induced magnetic phase transition (2003)

A study of a magnetic phase state of Nd2Fe14B high-energy hard ferromagnets subjected to longitudinal-shock-wave compression (where the shock wave propagates along magnetization vector M) has been performed. The results of the investigation show that longitudinal-shock-wave compression of Nd2Fe14B at 28–38 GPa causes a magnetic phase transition terminated by practically complete demagnetization of Nd2Fe14B. Due to this phase transition all electromagnetic energy stored in Nd2Fe14B is released and can be transformed into pulsed power. Explosive-driven autonomous sources of primary power utilizing this effect are capable of producing high-current pulses [current amplitude of 1.0 kA, full width at half maximum (FWHM) of 165 μs] and high-voltage pulses (peak voltage of 13.4 kV, FWHM of 8.2 μs).
Structural and Photophysical Characterization of Ag Clusters in LTA Zeolites (2019)

Ag clusters (AgCLs) confined within Na-exchanged Linde type A zeolites are studied by X-ray absorption and steady-state and time-resolved photoluminescence spectroscopies in a coordinated effort to elucidate the photophysical properties and link them to the precise cluster structure. The hydrated sodalite cage contains mostly tetrahedral [Ag4(H2O)4] clusters located at the center of the sodalite cages, whereas octahedral Ag6 clusters coordinated with the zeolite framework oxygen (OF) [Ag6(OF)14] are formed upon dehydration. The time-dependent density functional theory and electron spin resonance reports suggest that both Ag4 and Ag6 clusters have formally a double positive charge of 2+. Time-resolved spectroscopy shows that at room temperature, the emission of the hydrated sample decays with 3.4 ns from a state with the same multiplicity as the ground state. Upon dehydration, the entire excited-state dynamics speeds up to 1.2 ps. The microsecond-scale lifetimes observed at 77 K suggest the occurrence of two main decay processes for the initially populated singlet state: intersystem crossing and charge transfer. We show that the intersystem crossing yields the formation of a long-lived (409 μs) triplet state 3P from the 1P state located at lower energy from which luminescence occurs. There is evidence that electron transfer is followed by electron–hole recombination or back electron transfer, yielding a relaxed singlet excited state. Upon removal of water ligands, the electrostatic field of the framework is enhanced, which leads to an increase in the rate constant of charge transfer due to stronger electronic coupling between Ag62+ and trap levels. The dependence of luminescence lifetime on the water content indicates a possible way to speed or delay the electron–hole recombination in a controlled way.
Efficient Calibration of Feedback DAC in Delta Sigma Modulators (2020)

Feedback digital to analog converter non-linearity is one of the factors that limit performance of delta sigma modulators. Various mismatch shaping and non-linearity calibration schemes exist, but they either require additional element shuffling hardware or reconfiguration of the sigma delta modulator for calibration. In this brief, an efficient in-situ calibration scheme is presented which neither requires any analog hardware nor requires reconfiguration for calibration. Simulation results show that calibrated coefficients can be used to correct for mismatch induced increase in noise floor and non-linearity to achieve nearly ideal performance.
Plasma Dynamics in Low-Pressure Capacitively Coupled Oxygen Plasma Using PIC–MCC/Fluid Hybrid Model (2011)

Low-pressure ( <; 20 mT) capacitively coupled plasmas are now widely used for plasma processing in the semiconductor industry. In particular, O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> plasmas are being used for etching, photoresist ashing, and chamber cleaning. At low pressure, the electron mean free path increases, making kinetic effects more important. To consider kinetic effects, a hybrid plasma simulation tool has been developed that couples the particle-in-cell/Monte Carlo collision model for charged species with a fluid model for neutral species. Oxygen plasma has been modeled using this hybrid model for a range of pressures. It is observed that the electrons primarily absorb power at the sheath edge during sheath expansion. These energetic beam electrons are responsible for plasma production and sustenance through collisions. The beam electrons are stronger at lower pressure and retain their beam characters for a longer distance. For a constant RF voltage, the electron density increases with pressure.
Fabrication of asymmetrically coated colloid particles by microcontact printing techniques (2003)

We developed a novel method for preparation of asymmetrically coated colloid particles by using a microcontact printing technique. Films of water-insoluble ionic surfactants deposited on PDMS stamps were printed onto latex particle monolayers of opposite surface charge in order to produce spherical latex particles of dipolar surface charge distribution. We studied the effects of salt on the aggregation of such dipolar particles in aqueous suspensions. Upon addition of salt, dipolar colloid particles were found to give “linear” aggregates. We then extended this microcontact printing technique to the directed assembly of colloidal particles. Microcontact printing of one colloidal monolayer over a latex particle monolayer of opposite charge was used to fabricate particles of complex internal structure. We demonstrated that if the two colloid monolayers consist of particles of comparable sizes, this method allows fabrication of particle doublets. When the particle monolayer was stamped with another colloid monolayer of much smaller particle size complex structures as half-coated “raspberry”-like particles were obtained. Possible applications of these asymmetrically coated colloids include photonic crystals with novel symmetries, colloidal substitutes for liquid crystals and water-based electrorheological fluids.
Study on traffic safety evaluation of urban bus stop (2015)

In urban bus stop and its neighboring area, traffic conflicts among buses, other vehicles and non-motor vehicles happen frequently, and cause traffic accidents to occur easily. In this paper, traffic safety situation in urban bus stop was taken as study object. Method of traffic safety comprehensive evaluation based on traffic conflict technology being applied, some issues on traffic safety evaluation of urban bus stop were explored. In the process of traffic safety evaluation, the first task was the analysis of traffic conflict in urban bus stop. Secondly, traffic conflict survey in urban bus stop had been done and the traffic conflict data gotten. Finally, summarized the effects of two aspects of conflict rate and average conflict severity, traffic safety comprehensive evaluation model of urban bus stop had been proposed, and the effectiveness and practicability of this method had been verified by case study. The study results suggest that method of traffic safety comprehensive evaluation based on traffic conflict technology is an effective tool on traffic safety evaluation of urban bus stop.
ChemInform Abstract: ENANTIOSELECTIVE SYNTHESIS OF E,E‐DIENE ALCOHOLS AND ETHERS (1985)

Abstract Aus dem Dienyl‐ aldehyd (I) erhält man nach Grignard das Addukt (II), dessen Ether (IE1) zu den Isomeren (IV) und (V) dekomplexiert welrden.
Defective INPP5E distribution in NPHP1‐related Senior–Loken syndrome (2020)

The decreased expression of INPP5E specifically in the primary cilium, coupled with disorganized cilia morphology, suggests a novel role of NPHP1 that it is involved in regulating ciliary phosphoinositide composition in the ciliary membrane of renal tubular cells.
Weekly Irinotecan in Patients with Metastatic Gastric Cancer Failing Cisplatin-based Chemotherapy (2004)

This weekly schedule of irinotecan was modestly active against cisplatin-refractory gastric cancer and relatively well-tolerated with appropriate dose modification.
Imaging the Effects of Capillary Heterogeneities on Local Saturation Development in Long Corefloods (1994)

Summary Experiments on the effects of capillary heterogeneities and permeability variations on local saturation distributions were conducted using a nuclear saturation imaging technique. Capillary heterogeneities were obtained in alternating sand layers with different permeabilities in the direction of displacement. The paper reports wetting-phase accumulation at the transition zones, step-like saturation profiles, various recovery efficiencies, and different local residual saturations.
ChemInform Abstract: Convergent Synthesis of Polyether Ionophore Antibiotics: Synthesis of the Spiroketal and Tricyclic Glycal Segments of Monensin. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A compressive sensing approach to moving target indication for urban sensing (2011)

In this paper, we apply compressive sensing to moving target indication for urban sensing and through-the-wall imaging applications using stepped-frequency radar. In particular, we consider sparsity-driven imaging combined with change detection. Stationary targets and clutter are removed via change detection, resulting in a sparse scene of few slow-moving targets inside enclosed structures and behind walls. Using compressive sensing, a sizable reduction in the number of samples is achieved without degradation in system performance. Laboratory experiments are conducted to validate the proposed approach.
An Analysis of Seven Different Methods to DiagnoseHelicobacter pyloriInfections (1998)

The non-invasive tests UBT and WB are reliable, both alone and in combination, and they are recommended for the pre-endoscopic diagnosis of H. pylori. WB is recommended as a confirmative test for antibody detection by EIA. When patients have an upper endoscopy, we recommend taking biopsy specimens for culture and histology because of the additional information obtained about susceptibility, virulence determinants, and morphology, including the degree of inflammation.
Results from the phase 1/2 study of patritumab deruxtecan, a HER3-directed antibody-drug conjugate (ADC), in patients with HER3-expressing metastatic breast cancer (MBC). (2022)

1002 Background: Patritumab deruxtecan (HER3-DXd) is a novel, investigational ADC composed of a human anti-HER3 monoclonal antibody covalently bound to a topoisomerase I inhibitor payload via a stable tetrapeptide-based cleavable linker. Here we report updated safety and efficacy data from this ongoing study (U31402-A-J101; NCT02980341; JapicCTI-163401) of HER3-DXd in pts with previously treated MBC. Methods: U31402-A-J101 is a phase 1/2, multicenter, open-label, first-in-human study of HER3-DXd in pts with HER3-expressing MBC (N = 182). The study enrolled pts in dose-escalation (3.2-8.0 mg/kg IV Q3W) and dose-finding portions across molecular subtypes (n = 66; including HER2+ MBC, n = 14) followed by dose expansion in the following subtypes: HER3 high (4.8 mg/kg [n = 33] or 6.4 mg/kg [n = 31]), HER3 low (6.4 mg/kg [n = 21]) HR+/HER2− MBC or HER3-high TNBC (6.4 mg/kg [n = 31]). HER3-high and -low were defined as ≥75% and 25% ‒ &lt; 75% membrane positivity. The primary objective was to assess safety and efficacy; secondary objectives included determining the relationship between efficacy and HER3 expression. Results: At data cutoff (16 Aug 2021), median study duration was 31.9 mo (range, 15-56). Median age was 57 y (range, 30-83); 132 (72.5%) and 50 (27.5%) pts had an ECOG PS of 0 or 1. Pts had a median of 5 (range, 1-13) prior lines of therapy for locally advanced/metastatic disease. Median treatment duration with HER3-DXd was 5.9 mo (range, 0.7-30.6). In a pooled evaluation of dose escalation/finding and expansion, efficacy is shown in pts with HR+/HER2− MBC, TNBC, and HER2+ MBC in the Table. Overall, 130 pts (71.4%) had grade ≥3 TEAEs; the most common (≥15%) were decreased neutrophil count (39.6%), decreased platelet count (30.8%), anemia (18.7%), and decreased white blood cell count (18.1%). 12 pts (6.6%) experienced treatment-related interstitial lung disease according to central adjudication, including 1 grade 5 event. Conclusions: A pooled analysis in this heavily pretreated population showed promising efficacy in pts with HR+/HER2− and HER2+ MBC as well as TNBC. The safety profile with longer follow-up is consistent with previous reports and showed adequate safety and tolerability. Studies are ongoing in MBC tumor types, with a focus on biomarkers associated with efficacy. Clinical trial information: NCT02980341. [Table: see text]
Supplementary Tables from Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma (2023)

&lt;p&gt;Supplementary Tables show: i) Supplementary Table 1. Genes subjected to targeted deep sequencing; ii) Supplementary Table 2. CHIP-associated mutations observed by NGS in the cohort of 39 cHL patients; iii)Supplementary Table 3. List of somatic mutations observed in the samples of Case-1 by targeted NGS.&lt;/p&gt;
Utilizing the index for mortality prediction after cardiac transplantation risk score to predict hospital resource consumption (2020)

This is the first study in adult cardiac transplantation to identify a positive correlation between hospital cost and recipient risk using the IMPACT risk score. Cost and resource consumption for the index admission after OHTx were significantly higher in the highest IMPACT risk Q compared with patients in the lowest Q.
Collision warning radar interference (2002)

Collision warning radar is a potentially significant application of radar technology to the automotive market. In early stages of collision warning radar deployment, the likelihood of radar malfunction due to interference will be low. However, it is anticipated that as the number of fielded radars increases, systems designed without consideration of the interference problem will exhibit poor or degraded performance. Radars can be designed to minimize their susceptibility to interference. This paper focuses on what happens when many or most vehicles are equipped with a collision warning radar, and determines the level of interference expected when most vehicles employ a collision warning radar.
Impact of surface modification of green algal biomass by phosphorylation on the removal of copper(II) ions from water (2017)

A series of batch lab-scale experiments were performed to investigate the performance of dead phosphorylated algal biomass of Spirogyra species for the bioadsorption of Cu$^{+2}$ ions from aqueous solutions. FT-IR and SEM analyses were performed to characterize the phosphorylated and raw algae. The SEM analysis indicated that the phosphorus content increases by about 5 times. The isotherm equilibrium data indicated that phosphorylation enhances the removal of Cu$^{+2}$ from water by about 20%. The experimental isotherms fit well to Langmuir models with $R^{2}$ values close to 0.99. Adsorption kinetic study was conducted to investigate the effect of initial Cu$^{+2}$ concentrations, pH, and adsorbent dose on the loading capacity of algal biomass. The optimum pH for the process was around 6 and the corresponding maximum loading capacity was 65 mg/g. The pseudo second-order kinetics successfully modeled the kinetic results with $R^{2}$ values closed to 0.99. The thermodynamic results indicated that the bioadsorption process is endothermic and spontaneous at initial Cu$^{+2}$ concentrations lower than 100 mg/L. The results were promising and encourage the design of a continuous process using algal biomass to remediate water polluted with heavy metals.
ChemInform Abstract: A Fluorogenic “Click” Reaction of Azidoanthracene Derivatives. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis (2020)

Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients.
Anisotropy sensitivity of an acoustic lens with slit aperture (1993)

A conventional spherical acoustic lens is modified by restricting its aperture in the form of a slit to provide directional sensitivity. The spacing between the two parallel absorbing sheets forming the slit is adjustable to obtain varying slit widths. The resulting lens can be used in conjunction with V(Z) method to obtain leaky wave velocities of the sample under investigation as a function of direction. The theoretical V(Z) analysis of the lens involves a two-dimensional integral rather than one-dimensional integral of the conventional lens. Single crystal anisotropic materials are chosen as test samples. Reflection coefficients for anisotropic single crystals of given surface cut and orientation are calculated. Numerically evaluated V(Z) curves are used to deduce the surface wave velocity of the object for the given orientation. This is compared with the surface wave velocity directly calculated from the elastic parameters of the object. Results show the compromise between signal-to-noise ratio and angular resolution as the slit width is varied. V(Z) measurement results of a slitted lens are presented to be compared with calculated curves. The new lens is used to measure the acoustic velocity on the (001) surface of GaAs along varying directions with differing slit widths
Urban Pigeons (Columba livia) as a Source of Broad-Spectrum β-Lactamase-Producing Escherichia coli in Lisbon, Portugal (2022)

Wild birds may be healthy carriers, and therefore, may be involved in the dissemination of clinically relevant antimicrobial-resistant bacteria, such as extended-spectrum β-lactamases (ESBL) and carbapenemase-producing <i>Enterobacteriaceae</i>. This study evaluated whether urban pigeons living in five spots in Lisbon, Portugal, may be colonized and, therefore, constitute potential spreaders of multidrug-resistant bacteria. A total of 100 pigeon fecal samples were collected in different urban areas for the detection of ESBL- or carbapenemase-producing <i>Enterobacteriaceae</i>. All β-lactamase-producing isolates were tested for antimicrobial susceptibility and their genetic backgrounds were characterized by multilocus sequence typing. Of the 100 fecal samples collected, nine ESBL-producing <i>Escherichia coli</i> (9%) were identified. Three isolates carried the <i>bla</i><sub>CTX-M-15</sub> gene, three isolates harbored the <i>bla</i><sub>CTX-M-27</sub> and three isolates carried the <i>bla</i><sub>SHV-12</sub> gene. Genotyping of the nine ESBL-producing <i>E. coli</i> strains revealed seven different sequence types (STs) including ST10, ST131, ST154, ST206, ST1488 (SLV ST10), ST2858 and ST3576, most of which have been already described in humans, animals or in the environment. Urban pigeons constitute a potential source of ESBL genes and may be a transmission vehicle of multidrug-resistant bacteria in the environment.
Hypervalent Iodine(III)-Mediated Cyclization of Unsaturated N-Alkoxyureas: Cationic Oxybromination vs. Radical Aminobromination and Aminooxyamination (2019)

&lt;div&gt;In this study we describe the reactivity of unsaturated N-alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert-butylcarbonyloxy)iodobenzene with tetrabutylammonium bromide or TEMPO triggers aminobromination or aminooxyamination reactions, respectively. Control experiments showed that while the first process is ionic, the other two follow a radical manifold.&lt;/div&gt;
ChemInform Abstract: Directing Convection to Pattern Thin Polymer Films (2013)

Abstract Review: 95 refs.