gebhart/patrepeval huggingface dataset:
Ectromelia-encoded protein B22 restricts CD4+ T cell activation. (2018)

Abstract Orthopoxviruses encode many immunomodulatory proteins that profoundly interfere with various aspects of the immune system. Ectromelia (ECTV) is the orthopoxvirus that naturally infects mice, affording the opportunity to study viral-host interactions that have co-evolved. Importantly, disease progression closely mimics that of monkeypox and smallpox in humans. CD4+ T cells are one immune cell type crucial for the control of ECTV and have important roles in both direct cytolytic killing of infected cells and helping B and CD8+ T cell activation. Here we show that ECTV infection of antigen presenting cells inhibits their ability to activate CD4+ T cells directly. However, the inhibitory mechanism is not straightforward as neither down-regulation of surface MHC-II nor soluble factors are responsible. A promising candidate protein for this inhibition is B22, which is located on the plasma membrane and has homologs in most virulent strains including smallpox and monkeypox, but not vaccine strains. Indeed, we have determined that B22 contributes substantially to ECTV virulence. Here we show that B22 is both necessary and sufficient to restrict CD4+ T cell activation, with experiments ongoing to elucidate the specific mechanism of inhibition.
Energy Dependence of Elliptic Flow over a Large Pseudorapidity Range inAu+AuCollisions at the BNL Relativistic Heavy Ion Collider (2005)

This Letter describes the measurement of the energy dependence of elliptic flow for charged particles in Au+Au collisions using the PHOBOS detector at the Relativistic Heavy Ion Collider. Data taken at collision energies of square root of s(NN)=19.6, 62.4, 130, and 200 GeV are shown over a wide range in pseudorapidity. These results, when plotted as a function of eta(')=|eta|-y(beam), scale with approximate linearity throughout eta('), implying no sharp changes in the dynamics of particle production as a function of pseudorapidity or increasing beam energy.
Fatty Acid Toxicity and Methyl Ketone Production in Aspergillus niger (1970)

Vegetative hyphae of Aspergillus niger rapidly converted caproic acid into 2-pentanone. More caproic acid was required for maximal ketone production at alkaline as compared to acidic pH values. Further increases in caproate concentrations at each pH value tested (4.5, 5.5, 6.5, 7.5, and 8.5) resulted in inhibition of ketone production and O(2) uptake. At alkaline pH values (8.5 and 7.5), oxygen uptake above the endogenous level and the production of 2-pentanone were parallel. This relationship did not hold at acidic pH values. At these pH values, ketone production continued (pH 6.5) or attained a maximum (pH 5.5 and 4.5) at caproate concentrations at which oxygen uptake was inhibited below endogenous levels. These data indicate that endogenous oxygen uptake was not inhibited by caproate at alkaline pH values at concentrations which did inhibit caproate oxidation and 2-pentanone production. Conversely, at acidic pH values, endogenous oxygen uptake was vigorously inhibited by caproate at concentrations at which exogenous fatty acid oxidation and 2-pentanone production were less affected. Simon-Beevers plots of these data showed that the undissociated acid was the permeant form of caproic acid. The fatty anion appeared to be the active or inhibitory form of caproate within the cell. Vegetative hyphae of A. niger were poorly buffered. Once the hyphae were washed and resuspended in phosphate buffer, they were well buffered towards inhibitory concentrations of caproic acid. These findings suggest that the primary mechanism(s) by which caproate inhibits oxygen uptake and ketone formation does not involve a change in the intracellular pH.
Measurements of voidage profiles in spouted beds (1994)

Abstract A fibre optic probe has been used to measure voidage profiles in the fountain, spout and annulus of spouted beds. The voidage in most of the annulus was found to be somewhat higher than the loose‐packed voidage and increased with increasing spouting gas flow rate, contrary to usual assumptions. There is a denser region in the annulus where the voidage was a little lower than the loose‐packed bed voidage. In the core of the fountain, the voidage decreased with height for low spouting gas flow rate, consistent with the model of Grace and Mathur (1978); however, at higher gas flow rate, it first increased with height and then decreased towards the fountain top. The radial profiles of local voidage were roughly parabolic in the lower portion of the spout and blunt in the upper portion.
Cloud computing with an emphasis on PaaS and Google app engine (2011)

The regeneration structure and biodiversity of trees and shrub species in under story of pure and mixed Oak plantations were investigated in Chamestan Forest and Rangeland Research Station of Iran. Planted species including Oak (as main species) and Hornbeam (as associated species). This species were planted in five proportions (100Q, 70Q:30C, 60Q:40C, 50Q:50C, 40Q:60Z) in Northern of Iran in 11 years ago. All of regenerating seedlings and saplings of woody plants were divided into two height classes of 15-200 cm and more than 200 cm. In biodiversity study dominance index of Berger-Parker, diversity index of Fisher alpha, richness index of Margalef and evenness index of Equitability J were used. The results showed that abundance and diversity of regenerated species in under story of all plantations of oak were more than unplanted control plots and also under 50Q:50C were more than pure stand of oak. The presence of primary forest species in under stories of mixed plantation showed the usage of these plantations in development of succession in natural
A Hexafluorophosphate‐Based Ionic Liquid as Multifunctional Interfacial Layer between High Voltage Positive Electrode and Solid‐State Electrolyte for Sodium Secondary Batteries (2023)

Abstract Sodium secondary batteries have gained accolades as future energy storage devices due to their low costs and environmental benignity, but are heavily impeded by the poor anodic stabilities of most electrolytes, including solid‐state electrolytes (SSE), that render them incompatible with high‐voltage positive materials. This study reports, for the first time, a new synthesis technique using a fluorohydrogenate ionic liquid (IL)precursor to prepare a [DEME][PF 6 ] ([DEME] + : N , N ‐diethyl‐ N ‐methyl‐ N ‐(2‐methoxyethyl) ammonium) with high yield and high purity. Herein, a Na[PF 6 ]‐[DEME][PF 6 ] IL is formulated and subjected to a series of electrochemical tests to validate its performance in battery applications. The present IL harbors a strong oxidative stability (up to 5.2 V on Pt and &gt;4.5 V on conductive carbon electrodes) that aids in the suppression of oxidative decompositions of one typical SSE, for example, beta alumina solid electrolyte (BASE), thereby extending their electrochemical window in hybrid SSE systems. A hybrid solid‐state Na secondary battery employing a high voltage positive electrode, Na 3 V 2 (PO 4 ) 2 F 3 , is assembled using the BASE/IL configuration, and features energy density and superior cycling performance. This work demonstrates that sandwiching an SSE between the oxidatively stable [PF 6 ] − IL can be an effective design for high voltage operation Na secondary batteries.
Vehicle Extraction Based On Focus Of Attention, Multi Feature Segmentation And Tracking (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
New Taxanes From Taxus brevifolia (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Taxanes From Taxus brevifoliaDavid G. I. Kingston, Douglas R. Hawkins, and Liza OvingtonCite this: J. Nat. Prod. 1982, 45, 4, 466–470Publication Date (Print):July 1, 1982Publication History Published online1 July 2004Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/np50022a019https://doi.org/10.1021/np50022a019research-articleACS PublicationsRequest reuse permissionsArticle Views351Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Empoderamiento de ciudadanos inmigrantes mediante el diseño participativo de plataformas sociales digitales. La apropiación del móvil en ciudadanos inmigrantes (2017)

El proyecto APPS4ME (www.apps4me.es), impulsado por diferentes investigadores de la Facultad de Educación de la Universidad de Barcelona, pretende aportar mayor conocimiento sobre los usos de las tecnologías de personas migradas en la ciudad de Barcelona, para contribuir al desarrollo de proyectos encaminados hacia una acción comunitaria que permita dar respuesta a la exclusión social y digital. En concreto, el propósito es trabajar con comunidades de personas inmigrantes en riesgo de exclusión social mediante la metodología del diseño participativo, la cual fomenta la democracia participativa y da voz a los participantes que están involucrados desde el inicio del desarrollo del proyecto.\nPartimos de la propuesta de que el uso de las redes sociales y las tecnologías digitales móviles tienen un gran potencial inclusivo en este ámbito. Hay una gran cantidad de recursos y actividades de aprendizaje asociados a contextos específicos locales que pueden ser beneficiosos. El proyecto se centra en la búsqueda del diseño y la implementación de ecosistemas que permiten el empoderamiento de la comunidad inmigrante a través de actividades geolocalizadas, dispositivos móviles y redes de aprendizaje social.
Measurement of Hypoxia Using the Comet Assay Correlates with Preirradiation MicroelectrodepO2Histography in R3327-AT Rodent Tumors (2000)

Polarographic determination of tumor oxygenation by Eppendorf histography is currently under investigation as a possible predictor of radiotherapy outcome. Alternatively, the alkaline comet assay has been proposed as a radiobiological approach for the detection of hypoxia in clinical tumor samples. Direct comparisons of these methods are scarce. One earlier study with different murine tumors could not establish a correlation, whereas a weak correlation was reported for a variety of human tumors. Considering the different end points and spatial resolution of the two methods, a direct comparison for a single tumor entity appeared desirable. Anaplastic R3327-AT Dunning prostate tumors were grown on Copenhagen rats to volumes of 1-6 cm(3). Eppendorf histography (100-200 readings in 5 parallel tracks) for 8 different tumors revealed various degrees of oxygenation, with median pO(2) values ranging from 1.1 to 23 mmHg. Within 5 min after an acute exposure to 8 Gy (60)Co gamma rays, tumors were excised from killed animals and rapidly cooled to limit repair, and a single cell suspension was prepared for use with the comet assay. The resulting comet moment distributions did not exhibit two subpopulations (one hypoxic and the other aerobic), and a hypoxic fraction could not be calculated. Instead, the average comet moment distribution was taken as a parameter of overall strand break induction. Corresponding experiments with tumor cells grown in vitro allowed us to derive the relationship between the oxygen enhancement ratio (OER) for the average comet moment and oxygen partial pressure (Howard-Flanders and Alper formula). The validity of this relationship was inferred for cells exposed in situ, and the convolution of a pO(2) distribution with the formula of Howard-Flanders and Alper yielded an array of expected OER values for each tumor. The average expected OER correlated well with the average comet moment (r = 0.89, P < 0.01), and the in situ comet moment distributions could be predicted from the Eppendorf data when 50% repair was taken into account, assuming a 5-min damage half-life. The findings confirm the potential of interstitial polarography to reflect radiobiologically relevant intracellular oxygenation, but also underscore the confounding influence of differences in repair that may occur when cells are prepared from irradiated tissues for use with the comet assay.
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer (2022)

Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Design and Delivery of a Filter for Removal of Siloxanes from the ISS Atmosphere (2016)

Dimethylsilanediol (DMSD) has been identified as a problematic chemical contaminant aboard ISS. This contaminant was initially identified in the ISS condensate and in the Water Processor Assembly (WPA) product water in 2010 when an increasing total organic carbon (TOC) trend was detected in the water produced by the WPA. DMSD is not a crew health hazard at the levels observed in the product water, but it may degrade the performance of the Oxygen Generation System (OGS) which uses product produced by the WPA for electrolysis. In addition, DMSD can prevent the effective operation of the WPA catalytic reactor, and necessitates early replacement of Multifiltration Beds in the WPA. An investigation into the source of DMSD has determined that polydimethylsiloxanes (PDMSs) are hydrolyzing in the Condensing Heat Exchanger (CHX) to form DMSD. PDMSs are prevalent aboard ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallics. TPDMSs are also implicated in CHX hydrophilic coating degradation, rendering it hydrophobic and adversely affecting its ability to effectively transmit water to the condensate bus. Eventually this loss in performance results in water droplets in the air flow out of the CHX core, which can lead to microbial growth in the air ducts and can impact the performance of downstream systems. Design concepts have now been developed for removing PDMS in the air stream before it can reach the CHX core, thus preventing degradation of the coating and decomposition of the PDMS to DMSD. This paper summarizes the current status of the effort to deliver filters to ISS for removing PDMSs from the atmosphere before they can adversely impact the performance of the CHX coating and the WPA.
Bradykinin Lowers the Threshold Temperature for Heat Activation of Vanilloid Receptor 1 (2002)

Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of protein kinase C (PKC). It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects. In this study, we examined how BK modulates the activity of VR1. We measured VR1 currents using the patch-clamp technique in human embryonic kidney-derived (HEK293) cells expressing VR1 and B2 BK receptor. We found that BK lowered the threshold temperature for activation of VR1 currents in HEK cells down to well below the physiological body temperature in a concentration-dependent manner through PKC activation. We also demonstrated that in capsaicin-sensitive dorsal root ganglion (DRG) neurons the activation threshold of heat-induced current, which is considered to be VR-1 mediated, was lowered by BK and that this effect was also mediated by PKC. These data further support the supposition that modulation of VR1 is a mechanism for the BK-induced excitation of nociceptors and their sensitization to heat.
X-Ray Scattering from Semiconductors and Other Materials (2012)

X-ray Scattering Semiconductor Analysis X-ray Instrumentation X-ray Theory Structural Properties of Materials.
Context Combined Cascaded Region Proposal Network with Dual Loss Function for Accurate Car Detection (2018)

Car detection in the wild suffers from the problem of high occlusion and complicated scene disturbance. In this paper, we propose a novel Context Combined Cascaded Region Proposal Network (C3RPN) with dual loss function which addresses these problems at three dimensions: (i) we propose a cascaded two-stage region proposal structure that removes the limitation of fixed anchor boxes, (ii) Smooth L1 loss and Intersection over Union (IoU) loss are adopted to optimize the two stages respectively for better convergence and finer proposal regression, (iii) we integrate the complementary information between the proposed area and its context to strengthen the ability of accurate localization. We conduct extensive experiments on KITTI benchmark to prove the effectiveness of C3RPN. Results show that the proposed C3RPN outperforms Faster-RCNN with a large margin of 10.91% relative mAP gain and is robust to occlusion and background variation.
Effect of organic acids on the growth of rice and wheat seedlings supplied with ammonium and nitrate. (1985)

Using Norin No.41 of rice or Tohoku No.104 of wheat, effect of pyruvate, succinate and glycolate on the growth of seedlings supplied with ammonium or nitrate were studied. The results are summarized as follows : 1. Rice (Table 2 and 3) The growth of top, seminal root and crown root was promoted by the three organic acids. Ammonium enhanced the growth of top, but inhibited the growth of seminal and crown roots. Nitrate accelerated the growth of top, seminal root and crown root. In the mixture of each one of organic acids and either ammonium or nitrate, the growth of top was not affected, however, seminal root was facilitated. The growth of crown root was especially enhanced in the mixture of organic acids and ammonium. 2. Wheat (Table 4 and 5) The promoting effects were found on the top and seminal root in pyruvate and succinate treatments but not in glycolate. The growth of top was enhanced by nitrate, but seminal root was not affected by ammonium or nitrate. The growth of top was also progressed in case of the mixture of either pyruvate or succinated and ammonium, and, on the other hand, that of seminal root was promoted in the mixture of both ammonium and nitrate with every organic acid, excepting in combination of nitrate with glycolate. From above results, it was found that influences on the growth in accordance with these organic acids were greater in rice than in wheat, and the effect of glycolate on the growth of rice differed from that of wheat.
Primary myelofibrosis evolving to an aplastic appearing marrow (2018)

Our case highlights a series of bone marrow biopsies from a patient with primary myelofibrosis. Over time, this patient developed an unusual fatty appearance to his marrow, confirmed on multiple biopsies. This finding was supported by a quantitative fat MRI sequence that also shows a fatty appearance to the marrow.
Localizzazione del difetto in un albero dalla misura degli spostamenti delle frequenze di vibrazione torsionale (2002)

In questo manoscritto è stata calcolata la Sensibilità Modale Locale alla Cricca per un albero in differenti condizioni al contorno soggetto a vibrazioni torsionali. Misurando la variazione del comportamento dinamico del corpo dovuta alle sue modifiche strutturali, questa funzione ha permesso di individuare e localizzare con buona precisione fratture anche di lieve profondità realizzate sull’albero
Electron Transfer and Conformational Change in Complexes of Trimethylamine Dehydrogenase and Electron Transferring Flavoprotein (2002)

The trimethylamine dehydrogenase-electron transferring flavoprotein (TMADH.ETF) electron transfer complex has been studied by fluorescence and absorption spectroscopies. These studies indicate that a series of conformational changes occur during the assembly of the TMADH.ETF electron transfer complex and that the kinetics of assembly observed with mutant TMADH (Y442F/L/G) or ETF (alpha R237A) complexes are much slower than are the corresponding rates of electron transfer in these complexes. This suggests that electron transfer does not occur in the thermodynamically most favorable state (which takes too long to form), but that one or more metastable states (which are formed more rapidly) are competent in transferring electrons from TMADH to ETF. Additionally, fluorescence spectroscopy studies of the TMADH.ETF complex indicate that ETF undergoes a stable conformational change (termed structural imprinting) when it interacts transiently with TMADH to form a second, distinct, structural form. The mutant complexes compromise imprinting of ETF, indicating a dependence on the native interactions present in the wild-type complex. The imprinted form of semiquinone ETF exhibits an enhanced rate of electron transfer to the artificial electron acceptor, ferricenium. Overall molecular conformations as probed by small-angle x-ray scattering studies are indistinguishable for imprinted and non-imprinted ETF, suggesting that changes in structure likely involve confined reorganizations within the vicinity of the FAD. Our results indicate a series of conformational events occur during the assembly of the TMADH.ETF electron transfer complex, and that the properties of electron transfer proteins can be affected lastingly by transient interaction with their physiological redox partners. This may have significant implications for our understanding of biological electron transfer reactions in vivo, because ETF encounters TMADH at all times in the cell. Our studies suggest that caution needs to be exercised in extrapolating the properties of in vitro interprotein electron transfer reactions to those occurring in vivo.
Axis transform to characterise a monopulse twist reflector antenna and radome in an anechoic chamber (2014)

This paper presents a novel axis transform for a 3 axis positioner system located in an anechoic chamber. It allows for the true measurement of a twist reflector antenna with a radome. This progresses the field of antenna measurement as, uniquely, this axis transform allows the measured aberration caused by the antenna radome to be included. Simulated and measured results are shown to validate the use of the proposed transform.
Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.