gebhart/patrepeval huggingface dataset:
Spiroconjugation (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpiroconjugationHoward E. Simmons and Tadamichi. FukunagaCite this: J. Am. Chem. Soc. 1967, 89, 20, 5208–5215Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://doi.org/10.1021/ja00996a022Request reuse permissionsArticle Views1551Altmetric-Citations266LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (922 KB) Get e-Alertsclose Get e-Alerts
Detection and quantification of intraperitoneal fluid using electrical impedance tomography (2001)

A prototype electrical impedance tomography system was evaluated prior to its use for the detection of intraperitoneal bleeding, with the assistance of patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The system was sensitive enough to detect small amounts of dialysis fluid appearing in subtractive images over short time periods. Uniform sensitivity to blood appearing anywhere within the abdominal cavity was produced using a post-reconstructive filter that corrected for changes in apparent resistivity of anomalies with their radial position. The image parameter used as an indication of fluid quantity, the resistivity index, varied approximately linearly with the quantity of fluid added. A test of the system's response to the introduction of conductive fluid out of the electrode plane (when a blood-equivalent fluid was added to the stomach) found that the sensitivity of the system was about half that observed in the electrode plane. Breathing artifacts were found to upset quantitative monitoring of intraperitoneal bleeding, but only on time scales short compared with the fluid administration rate. Longer term breathing changes, such as those due to variations in the functional residual capacity of the lungs, should ultimately limit the sensitivity over long time periods.
Improvement of multisensor fusion in speed limit determination by quantifying navigation reliability (2010)

Speed limit determination is a complex task that may be solved by fusing data from GIS (Geographical Information System) and camera sensor. Among the existing data fusion models the Dempster-Shafer Belief Theory is found to be the most appropriate in this application. A confidence measure weights each source output, namely speed limit present on road sign and driving situation. Using the discounting scheme of Dempster-Shafer, we propose a new way of computing the navigation confidence measure by taking into account the reliability of the GIS. Preliminary tests showed that our method achieves promising results and solves conflicts between vision- and navigation-based system.
CONFORMATIONAL AND STRUCTURAL STUDIES OF 2-FLUORO-2-OXO-1,3,2-DIOXAPHOSPHORINANES (1981)

Abstract Reaction of 2-chloro-2-oxo-4,6-dimethyl-1,3,2-dioxaphosphorinane with KF and a catalytic amount of 18-crown-6-ether gives a mixture of two isomers (5a and 5b) which are anancomeric at phosphorus. While the stable isomer could be obtained pure, attempts to isolate the unstable isomer resulted in mixtures. Nmr (31P, 13C and 19F) and dipole moment measurements on the stable isomer and the isomer mixture are consistent with the presence of an axial fluorine in the stable isomer. This is strongly supported by the observation that the 5,5-dimethyl analogue of 5, contains an axial fluorene as determined by x-ray diffraction techniques. The earlier conclusion (Ref. 3) that 1JPFax > 1JPFeq in the isomeric 4-methyl analogues of 5a and 5b is supported by our investigations and a rationale for this unusual coupling relationship is put forth.
Hybridization Properties of 4′-Branched Oligonucleotides (2003)

Click to increase image sizeClick to decrease image sizeKey Words: 4′-Branched oligonucleotidesHybridizationTriplexesSugar conformationNuclease stability Acknowledgments Support by grants # A4055101 (Acad. Sci., Czech Republic) and #203/01/1166 (GA, Czech Republic) under research project Z4055905 is gratefully acknowledged.
The uses of psychotropics in symptom management in advanced cancer (1998)

Approximately 50% of patients diagnosed with cancer die because of progressive disease. Psychotropic drugs are frequently used for the management of physical and psychosocial symptoms in these patients. Thalidomide, cannabinoids and melatonin are emerging agents for the management of cachexia. Psychostimulants have a defined role in the management of opioid-induced sedation. Haloperidol, tricyclic anti-depressants and newer anti-depressants also have an established role in the management of neuropsychiatric symptoms such as delirium or depression. Cancer patients present unique challenges for successful psychotropic therapy including older age, malnutrition, autonomic failure, borderline cognition, opioid and psychotropic therapy. A practical clinical approach which defines a specific target symptom, an outcome latency period, expected side effects, and reviews possible drug interactions, and frequent monitoring is outlined. Continued research is needed to further define the role of psychotropics in the management of the different physical and psychosocial symptoms in advanced cancer patients.
A variably imprinted epiallele impacts seed development (2018)

The contribution of epigenetic variation to phenotypic variation is unclear. Imprinted genes, because of their strong association with epigenetic modifications, represent an opportunity for the discovery of such phenomena. In mammals and flowering plants, a subset of genes are expressed from only one parental allele in a process called gene imprinting. Imprinting is associated with differential DNA methylation and chromatin modifications between parental alleles. In flowering plants imprinting occurs in a seed tissue - endosperm. Proper endosperm development is essential for the production of viable seeds. We previously showed that in Arabidopsis thaliana intraspecific imprinting variation is correlated with naturally occurring DNA methylation polymorphisms. Here, we investigated the mechanisms and function of allele-specific imprinting of the class IV homeodomain leucine zipper (HD-ZIP) transcription factor HDG3. In imprinted strains, HDG3 is expressed primarily from the methylated paternally inherited allele. We manipulated the methylation state of endogenous HDG3 in a non-imprinted strain and demonstrated that methylation of a proximal transposable element is sufficient to promote HDG3 expression and imprinting. Gain of HDG3 imprinting was associated with earlier endosperm cellularization and changes in seed weight. These results indicate that epigenetic variation alone is sufficient to explain imprinting variation and demonstrate that epialleles can underlie variation in seed development phenotypes.
Biomimetic Silica Encapsulation of Nanoparticles and Enzymes (2008)

In nature, several organisms elegantly deposit silica into shell and spicule structures. These include the unicellular algae family of diatoms (1, 2) as well as the marine sponges (3, 4). The basis for silica deposition in these organisms has been elucidated over the last several years. Families of proteins, termed silaffins in diatoms and silicateins in marine sponges, have been isolated from the silacious components of the respective organisms (1, 3). These protein families do not resemble each other in terms of sequence or isoelectric point, but the purified forms of each precipitate silica from silicic acid precursors (1, 4). The in vitro protein-mediated silica condensation reactions were the proof-of-concept that these organisms use proteins to deposit and/or template their intricate silica structures. Interestingly, these silica precipitating templates become entrapped with the silica matrix. The composite protein-silica structure found in nature was the impetus for encapsulating enzymes in silica using peptides and proteins as the silica template. This chapter will focus on the encapsulation of nanoparticles and enzymes using peptide-templated silica.
Supplementary Table S3 from Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models (2023)

Supplementary Table S3 from Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models
Clinical and radiographic comparison of mini–open transforaminal lumbar interbody fusion with open transforaminal lumbar interbody fusion in 42 patients with long-term follow-up (2008)

Mini-open TLIF is a viable alternative to traditional open TLIF with significantly reduced estimated blood loss and LOS. However, the authors found a higher incidence of hardware-associated complications with the mini-open TLIF.
Digital Image Processing to Remove Blur from Linear Tomography of the Lung (1991)

We have studied digital image processing methods to reduce blur in linear tomography of the lung performed with the Fuji computed radiography (FCR) system. One-dimensional unsharp (blur) mask filtering in the direction of tomographic movement was found to be effective in reducing blur. The appearance of the processed tomograms varied depending largely on the properties of the unsharp mask filters applied. With regard to the spatial frequency response of the filter, a high mid-frequency response and a low low-frequency response of the tomographic image data was most effective in obtaining high image quality tomograms. When the standard 2-dimensional unsharp mask technique of the FCR system was additionally applied to the one-dimensional unsharp mask processed tomogram, the clarity of the tomogram was further enhanced. These observations may also be helpful when considering image processing to obtain diagnostically informative digital radiography.
Automatic classification of tennis video for high-level content-based retrieval (2002)

We present our techniques and results on automatic analysis of tennis video to facilitate content-based retrieval. Our approach is based on the generation of an image model for the tennis court-lines. We derive this model by using the knowledge about dimensions and connectivity (form) of a tennis court and typical camera geometry used when capturing a tennis video. We use this model to develop: a court line detection algorithm; and a robust player tracking algorithm to track the tennis players over the image sequence. We also present a color-based algorithm to select tennis court clips from an input raw footage of tennis video. Automatically extracted tennis court lines and the players' location information are analyzed in a high-level reasoning module and related to useful high-level tennis play events. Results on real tennis video data are presented demonstrating the validity and performance of the approach.
Short-term comprehensive cardiac rehabilitation after AMI is associated with reduced 1-year mortality: results from the OMEGA study (2013)

Attendance to early, comprehensive short-term cardiac rehabilitation programmes on top of current guideline-adjusted treatment of acute myocardial infarction is associated with a significantly improved 1-year prognosis.
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform (2013)

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
Similarity-based disease risk assessment for personal genomes: proof of concept. (2011)

The increasing availability of personal genome data has led to escalating needs by consumers to understand the implications of their gene sequences. At present, poorly integrated genetic knowledge has not met these needs. This proof-of-concept study proposes a similarity-based approach to assess the disease risk predisposition for personal genomes. We hypothesize that the semantic similarity between a personal genome and a disease can indicate the disease risks in the person. We developed a knowledge network that integrates existing knowledge of genes, diseases, and symptoms from six sources using the Semantic Web standard, Resource Description Framework (RDF). We then used latent relationships between genes and diseases derived from our knowledge network to measure the semantic similarity between a personal genome and a genetic disease. For demonstration, we showed the feasibility of assessing the disease risks in one personal genome and discussed related methodology issues.
Duplexer design and implementation for self-interference cancellation in full-duplex communications (2016)

The full-duplex (FD) based devices are capable of concurrently transmitting and receiving signals with a single frequency band. However, a severe self-interference (SI) due to the large difference between the power of the devices' own transmission and that of the signal of interest may be imposed on the FD based devices, thus significantly eroding the received signal-to-interference-plus-noise ratio (SINR). To implement the FD devices, the SI power must be sufficiently suppressed to provide a high-enough received SINR for satisfying the decoding requirement. In this paper, the design and implementation of the duplexer for facilitating SI cancellation in FD based devices are investigated, with a new type of duplexer (i.e. an improved directional coupler) designed and verified. It is shown that the SI suppression capability may be up to 36 dB by using the proposed design, which is much higher than that attainable in the commonly designed ferrite circulator.
Lymphoscintigraphy in high-risk melanoma of the trunk: predicting draining node groups, defining lymphatic channels and locating the sentinel node. (1993)

Lymphoscintigraphy was performed in 209 patients with high-risk melanoma of the trunk referred to the Sydney Melanoma Unit and considered for lymph node dissection. Lymphoscintigraphy accurately defined the draining lymph node groups and was 94% sensitive in detecting draining sites that contained metastases. When combined with the clinical finding of palpable lymph nodes, the sensitivity rose to 98%. Most patients showed lymph drainage to one or two node groups and only 22 patients showed drainage to 3 or more node groups. The major lymph channels could also be marked on the skin prior to incontinuity dissection. Most patients had multiple draining lymph channels and these often diverged significantly from each other in the path to the draining node group. The number and location of interval nodes could be determined and marked on the skin. These and the major lymph channels could thus be excised at the time of surgery. Unusual drainage patterns were sometimes seen; for example, three patients displayed a new lymph pathway with direct drainage from the back anteriorly to the para-aortic nodes. The location of the sentinel nodes in each draining lymph-node group could also be marked on the skin prior to surgery, enabling quick and accurate identification of this node, using the blue-dye technique if biopsy were to be performed. These findings lead us to recommend lymphoscintigraphy prior to wide local excision in patients with truncal melanoma who are candidates for surgery. Lymphoscintigraphy results will help plan surgery and lead to minimum surgical intervention, consistent with effective surgical management.
FINAL ANALYSIS (2007)

First paragraph: Platinum (as well as many other metals) may&#13;\nbe prepared in finely divided forms that are&#13;\nporous at all levels of magnification. Cracks and&#13;\ncrevices in the sponge-like opaque matrix then&#13;\nallow visible light (of wavelength around 0.5 μm)&#13;\nto enter, whereupon it undergoes multiple reflections&#13;\nand is unlikely to be reflected back out. This&#13;\neffectively produces a high value for optical&#13;\nabsorption, resulting in a velvety black appearance&#13;\nto the eye, even though the platinum is in&#13;\nthe metallic state. Other porous structures (such&#13;\nas snow and plaster) consist of inherently transparent&#13;\nor translucent crystals, so light can be&#13;\nrefracted as well as reflected out and they appear&#13;\nmatt white.
Determining electron temperature and density in a hydrogen microwaveplasma (1993)

A three-temperature thermo-chemical model is developed for analyzing the chemical composition and energy states of a hydrogen microwave plasma used for studying diamond deposition. The chemical and energy exchange rate coefficients are determined from cross section data, assuming Maxwellian velocity distributions for electrons. The model is reduced to a zero-dimensional problem to solve for the electron temperature and ion mole fraction, using measured vibrational and rotational temperatures. The calculations indicate that the electron temperature may be determined to within a few percent error even though the uncertainty in dissociation fraction is many times larger.
Exposure to an extremely low-frequency electromagnetic field only slightly modifies the proteome of Chromobacterium violaceum ATCC 12472 (2015)

Several studies of the physiological responses of different organisms exposed to extremely low-frequency electromagnetic fields (ELF-EMF) have been described. In this work, we report the minimal effects of in situ exposure to ELF-EMF on the global protein expression of Chromobacterium violaceum using a gel-based proteomic approach. The protein expression profile was only slightly altered, with five differentially expressed proteins detected in the exposed cultures; two of these proteins (DNA-binding stress protein, Dps, and alcohol dehydrogenase) were identified by MS/MS. The enhanced expression of Dps possibly helped to prevent physical damage to DNA. Although small, the changes in protein expression observed here were probably beneficial in helping the bacteria to adapt to the stress generated by the electromagnetic field.
Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives. (1983)

Effects produced by intratumor or systemic application of FK-156 and its synthetic derivatives on the syngeneic P388-DBA/2 mouse system were investigated. Among 21 compounds tested, FK-156, FK-565, FR-46758, FR-48217, FR-46091 and FR-47920 substantially suppressed tumor growth when directly injected into a tumor mass and further experiments showed that FK-156, FK-565 and FR-46758 were effective even when administered subcutaneously into site remote from tumor. The mechanisms of growth inhibition are strongly suggested to be host mediated, because these three compounds have remarkably low cytotoxicity against P388 cells in vitro. A single dose of FK-565, however, markedly decreased body weight in healthy DBA/2 mice, whereas FK-156 and FR-46758 did not. These results indicate the superiority of FK-156 and FR-46758 as immunotherapeutic agents over FK-565 with respect to their safety for treatment of cancer. Although significant life-span prolongation could not be seen in the two-injection regimen of six compounds in either system, systemic multiple injections of FK-156 and FR-46758 provided a statistically significant increase in the median survival time of P388 tumor bearing mice.
Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination (2006)

LAPTM5 is a lysosomal transmembrane protein expressed in immune cells. We show that LAPTM5 binds the ubiquitin-ligase Nedd4 and GGA3 to promote LAPTM5 sorting from the Golgi to the lysosome, an event that is independent of LAPTM5 ubiquitination. LAPTM5 contains three PY motifs (L/PPxY), which bind Nedd4-WW domains, and a ubiquitin-interacting motif (UIM) motif. The Nedd4–LAPTM5 complex recruits ubiquitinated GGA3, which binds the LAPTM5-UIM; this interaction does not require the GGA3-GAT domain. LAPTM5 mutated in its Nedd4-binding sites (PY motifs) or its UIM is retained in the Golgi, as is LAPTM5 expressed in cells in which Nedd4 or GGA3 is knocked-down with RNAi. However, ubiquitination-impaired LAPTM5 can still traffic to the lysosome, suggesting that Nedd4 binding to LAPTM5, not LAPTM5 ubiquitination, is required for targeting. Interestingly, Nedd4 is also able to ubiquitinate GGA3. These results demonstrate a novel mechanism by which the ubiquitin-ligase Nedd4, via interactions with GGA3 and cargo (LAPTM5), regulates cargo trafficking to the lysosome without requiring cargo ubiquitination.
Construction of phagemid display libraries with PCR-amplified immunoglobulin sequences. (1994)

H H Hogrefe and B Shopes Stratagene Cloning Systems, La Jolla, California 92037, USA.
High Performance Parallel Decimal Multipliers Using Hybrid BCD Codes (2017)

A parallel decimal multiplier with improved performance is proposed in this paper by exploiting the properties of three different binary coded decimal (BCD) codes, namely the redundant BCD excess-3 code (XS-3), the overloaded decimal digit set (ODDS) code and the BCD-4221/5211 code. The signed-digit radix-10 recoding is used to recode the BCD multiplier to the digit set [-5, 5] from [0, 9]. The redundant BCD XS-3 code is adopted to generate the multiplicand multiples in a carry-free manner. The XS-3 coded partial products (PPs) are converted to ODDS PPs to fit binary partial product reduction (PPR). In this paper, a regular decimal PPR tree using ODDS and BCD-4221/5211 codes is proposed; it consists of a binary PPR tree block, a non-fixed size BCD-4221 counter block and a BCD-4221/5211 PPR tree block. The decimal carry-save algorithm based on BCD-4221/5211 is used in the PPR tree to obtain high performance multipliers. Moreover, an improved PPG circuit and an improved parallel prefix/carry-select decimal adder are proposed to further improve the performance of the proposed multipliers. Analysis and comparison using the 45 nm technology show that the proposed decimal multipliers are faster and require less hardware area than previous designs found in the technical literature.
COMPARISON OF NITROGEN DISTRIBUTION IN SLURRY-BED HYDROCRACKING AND THERMAL CONVERSION OF RESIDUES (2003)

The atmospheric residue from Kalamayi Refinery was hydrocracked in a 500 ml batch autocalve in the presence of adispersed catalyst. The reaction was conducted at temperatures of 430 ℃, 435 ℃, or 440 ℃,residence time of 1 h, catalyst content of 800μg/g(based on metal in feed), and initial hydrogen pressure of 7.0 MPa in a slurry-bed. It was also thermally cracked in the same batch autoclave, with the same reaction temperature and time as those of the slurry-bed. The reaction pro- ducts were separated into four fractions of IBP～180 ℃,180～360 ℃,360～500 ℃ and 500 ℃. The basic nitrogen in each fraction was determined by nonaqueous titration. The total nitrogen was determined by chemical illumination method. Compared with the nitrogen distribution of thermal conversion products, both the basic and the total nitrogen in products from the slurry-bed hydrogenation increased with the increase of the reaction temperature. The presence of dispersed catalyst, coexisting with hydrogen in the slurry-bed hydrogenation reaction system, promoted the conversion of nitrogen compounds in the feed obviously.