gebhart/patrepeval huggingface dataset:
Neutrophin signalling in first-episode psychosis: relationship with treatment response 1 year after the illness onset (2016)

Introduction Pro/antiinflammatory imbalance has been found in first-episode psychotic (FEP) patients, even 12 months later. Current research is every time more focused in the need to find biomarkers to understand the underlying pathophysiological mechanisms of this severe illness. Objectives To assess peripherical levels of neurotrophins and their receptors and their correlation with inflammation, clinical symptomatology and response to antipsychotic treatment, over the time. Methodology Ninety-four FEP patients and 80 matched healthy controls were included. Blood samples were taken at baseline to measure BDNF and NGF and their receptor levels (TrkB-full, TrkB-truncated and TrkA) and pro/antiinflammatory parameters (NFkB, COX-2, iNOS, PPARgamma, 15d-PG12). Patients were followed-up during 12 months. Results BDNF TrkB-full receptor and NFG TrkA receptor levels increased during the follow-up whereas BDNF TrkB-truncated form receptor decreased. After adjusting for confounding variables, baseline levels of proinflamatory variables were significantly related to TrkB-full/TrkB-truncated ratio (FL/T), suggesting that a higher proinflammatory status is related to a higher FL/T ratio expression. Furthermore, baseline FL/T ratio could have a predictor role of patient's functionality 1 year after the illness onset, depending on whether patient is treated or not with antipsychotic drugs. Conclusion Inflammatory processes, neurotrophic pathways and functional status of FEP patients seem to be related which is of great traslational relevance. Specific, the expression of the 2 isoforms of BDNF receptor should be taken into account before starting an antipsychotic drug treatment. Disclosure of interest The authors have not supplied their declaration of competing interest.
Lattice-relaxation effects at point imperfections in semiconductors (1975)

We discuss some of the fundamentally inherent limitations involved in calculations of lattice-relaxation effects at point imperfections. We show that differences of tetrahedral covalent radii between impurity and host atoms cannot reliably determine whether the nearest-neighbor atoms move inward or outward. A massive minimization-of-total-energy calculation may yield reliable information for deep levels but for shallow levels the problem is inherently intractable; even if one knew which way the neighboring atoms move, neither the sign nor the size of the change in binding energy could be determined reliably, either by a full calculation or, even more so, by qualitative arguments.
Revisiting the Placebo Effect (2019)

W Jean Dodds* Author Affiliations Hemopet, 938 Stanford Street, Santa Monica, California, USA Received: November 26, 2019 | Published: December 04, 2019 Corresponding author: W Jean Dodds, Hemopet, 938 Stanford Street, Santa Monica, California, USA DOI: 10.26717/BJSTR.2019.23.003915
Facile and scalable dry surface doping technique to enhance the electrochemical performance of LiNi0.64Mn0.2Co0.16O2 cathode materials (2020)

Nd-doped NMC shows significantly improved electrochemical performance.
Parameter monitoring and control in industrial sewing machines - an integrated approach (2008)

The industrial manufacturing of sewn products has always been one of the critical processes of the textile chain concerning quality assurance. Assuring the appropriate set-up and operation of all the machines, and thus the final seam quality, is a very complex task. Traditionally, this task is accomplished by empirical methods, with machine setting and quality control relying on the skills of operators and technicians. In this work, an approach to a more knowledge-based and integrated process planning and control is presented. A system was developed to measure and analyze the most important mechanical effects occurring during high-speed sewing. A general overview over this development is given in this paper.
Cytogenetic and molecular analyses of de novo translocation dic(9;13)(p11.2;p12) in an infertile male (2014)

We propose that the azoospermia observed in the patient with the dic(9;13)(p11.2;p12) translocation was most likely a consequence of a very high proportion (90%) of association between XY bivalents and quadrivalent formations in prophase I.
Abstract 4839: Mechanistic regulation of autophagy in the prostate cancer-bone marrow stromal microenvironment (2010)

Abstract Autophagy is the process of intracellular digestion to reallocate nutrients and clear cells of damaged proteins and organelles. Normally, autophagy maintains cellular homeostasis and enables cell survival in unfavorable growth conditions. Alternatively, sustained autophagy can result in autophagic death of genotoxic cells. Thus, autophagy serves as a rheostat between cell survival and cell death to maintain homeostasis in the whole organism. In the context of metastatic disease, invading cells hijack autophagic processes to survive in the host environment and/or induce host cell autophagic death to enable colonization. As the most fatal characteristic of cancer is metastasis, we sought to understand how autophagy is regulated in normal and tumor cells in the metastatic niche. Building on previous work which shows that cross-talk between metastatic prostate cancer (PCa) cells and bone marrow stromal cells alters gene expression, signaling cascades, and cell proliferation and differentiation in both cell types, we hypothesize that altered autophagy also contributes to tumorigenicity in the PCa-bone marrow stromal microenvironment. Thus we have set out to determine 1) if the PCa-bone marrow stromal microenvironment alters autophagy, 2) the mechanistic regulation of autophagy in microenvironment, and 3) if autophagy can be exploited to identify markers or inhibit metastatic PCa tumorigenicity in vivo. We are using cell and molecular biology techniques to investigate autophagic signaling in co-cultures, including acridine orange to stain for acidic vesicular organelles (AVOs) and western blot analysis of the autophagosome membrane protein, microtubule-associated protein 1 light chain 3 (LC3). Our preliminary results show that in the presence of PCa cell (C4-2B)-conditioned media, bone marrow stromal cells show a marked decrease in AVOs concomitant with a significant increase in the membrane-bound form of LC3, suggesting bone marrow stromal cells can mount an autophagic defense. While free LC3 is upregulated in PCa cells exposed to bone marrow stromal cell-conditioned media, we did not observe a change in AVO accumulation or an increase in membrane-bound LC3, potentially because these end stage bone-derived PCa cells cannot solicit an effective autophagic response. Based on these and previous data from our lab, we believe events occur in the bone marrow stromal microenvironment that elicit an early defense against prostate cancer cells but eventually enable surviving PCa and tumor stromal cells to adapt and form bony tumors. Our broad goal is that the elucidation of the mechanistic regulation of autophagy in the prostate cancer-bone marrow stromal microenvironment will aide in the rational design of therapies to target bone metastatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4839.
Grating couplers in polymer with a thin Si3N4 layer embedded (2012)

Polymer has been considered to be an ideal material option for integrated photonics devices. To measure these devices, normally the route of horizontal coupling is chosen to couple the light into or out of the polymer waveguide. Due to the relatively low refractive index, implementing the surface grating coupler in this material system remains to be a challenge. In this paper, we present a polymer based surface grating coupler. Rather than expensive CMOS fabrication, the device is fabricated through a simple and fast UV based soft imprint technique utilizing self-developed low loss polymer material. The coupling efficiency is enhanced by embedding a thin Si3N4 layer between the waveguide core and under cladding layer. Around -19.8dB insertion loss from single-mode fiber (SMF) to single-mode fiber is obtained for a straight waveguide with grating coupler at each end. If collected with multi-mode fiber (MMF), it can be reduced to around -17.3dB. The 3dB bandwidth is 32nm centered at 1550nm. The proposed surface grating coupler and its easy fabrication method would be attractive for practical applications.
Platelet aggregation in flowing blood at a site of injury to an endothelial cell monolayer: quantitation and real-time imaging with the TAB monoclonal antibody (1990)

Epifluorescence videomicroscopy permits real-time imaging of platelet adhesion/aggregation to a defined microinjury of a monolayer of endothelial cells exposed to flowing blood. The fluorescent label is the TAB murine monoclonal antibody directed against human platelet GP IIB, together with a fluorescein-conjugated goat F(ab')2 against murine immunoglobulin. The combination assures specificity for platelet membranes, yet leaves platelet function intact. TAB is first added to gently mixed, citrated human blood; the second antibody is added 1 hour after the first, mixing continuing for a second hour. Bovine aortic endothelial cell monolayers (ECMs), grown on rectangular cover glasses precoated with microfibrillar collagen, comprise one wall of a flow chamber mounted on a vertical microscope stage. A loop of 6–0 sterile suture is drawn across the ECM in order to create microinjuries of width 70 +/- 15 microns (mean +/- SD) oriented in a direction transverse to flow. Platelet adhesion/aggregation is virtually absent on intact and confluent regions of the monolayer. On micro-injury sites and at shear rates of 60 to 1,080 sec-1, however, computer-enhanced images obtained by means of videomicroscopy show arrival and adherence of single platelets resulting in the formation of platelet aggregates elongated in the flow direction. When the monolayers are pretreated with 1.0 mmol/L lysine acetylsalicylate, the mean aggregate thickness increases (2P less than .05) to 260 +/- 58% (mean +/- SE, N = 6) of control, aggregates are regularly shed downstream, and the surface area of the injury site covered by platelets is augmented (2P less than .05) from 14.8 +/- 3.9% to 49.2 +/- 4.7% (mean +/- SE, N = 6). Donor ingestion of aspirin, on the other hand, leads to an increase (2P less than .01) in percent surface coverage to 42.7 +/- 8.5 without a concomitant increase in mean aggregate thickness. In parallel with the above, outflow levels of serum thromboxane and prostacyclin are measured by radioimmunoassays (RIAs) for thromboxane B2 and 6-Keto-PGF1 alpha, respectively. Thromboxane B2 is increased (2P less than .01) by monolayer pretreatment with lysine acetylsalicylate from 5.08 +/- 1.47 to 9.35 +/- 2.42, but decreased (2P less than .05) after oral aspirin to 1.21 +/- 0.38 ng/mL (mean +/- SE, N = 6). Levels of 6-Keto-PGF1 alpha were reduced (2P less than .05) by monolayer pretreatment from 0.48 +/- 0.046 to 0.36 +/- 0.016 ng/mL. Platelet adhesion/aggregation at a site of injury to an endothelial cell monolayer, therefore, can be imaged in flowing blood in real time using a monoclonal antibody approach.(ABSTRACT TRUNCATED AT 400 WORDS)
Differences in symptom expression in older HIV-positive patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study experience. (2003)

Symptom recognition is critical for patient care but has been little studied in older HIV-infected individuals. The authors examined differences in symptom expression between younger (younger than age 50 years) and older (older than age 50 years) HIV-infected individuals. The authors analyzed data from two cross-sectional studies of HIV-infected individuals: 2864 individuals from the HIV Cost and Service Utilization Study (HCSUS) and 881 individuals from the Veterans Aging Cohort 3 Site Study (VACS 3). The authors compared the prevalence of eight symptoms common to both studies and 10 symptoms examined only in the VACS 3 population, stratified by age and race. Disease severity was assessed by CD4 count and 18 HIV-related diseases reported. Multivariate logistic regression models were used to account for demographics and severity differences. VACS 3 versus HCSUS participants were more likely nonwhite and older. In unadjusted comparisons, older nonwhites were less likely to report experiencing symptoms than younger whites. They reported the fewest total number of symptoms and the fewest individual symptoms common to both studies (headache, fever, nausea/vomiting, and diarrhea) or in the VACS 3 only (dizziness, sleeping difficulty, fatigue, rashes, bloating, and myalgias/arthalgias). Multivariate regression estimates suggest older age predicts a greater likelihood of reporting peripheral neuropathy, weight loss, or hair loss, but a lower likelihood of reporting headaches, depressed mood, white oral patches, or diarrhea. Nonwhites appeared less likely to report symptoms. Age is a determinant of reporting certain symptoms in HIV disease but may be masked or accentuated by other factors such as race.
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria (2011)

The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM. This review discusses the properties of the plant immune-modifier curcumin and its potential as an adjunctive therapy for the management of this complication.
Effect of Acetophenone on Dielectric Properties of Low-density Polyethylene (2022)

The development of Extra/Ultra high voltage (EHV/UHV) transmission requires high-performance insulating dielectrics. Dielectric properties of cross-linked polyethylene (XLPE) used in high-voltage insulated cables are key to ensuring the stability of EHV/UHV transmission line. Acetophenone is one of the main byproducts produced in XLPE after crosslinking with dicumyl peroxide (DCP). This paper intends to quantitatively investigate the effect of acetophenone on the dielectric properties of polyethylene. The low-density polyethylene (LDPE)/acetophenone composites with different contents of acetophenone are prepared by soaking pure LDPE samples in acetophenone for various times. Gas chromatography (GC) is employed to test the contents of acetophenone. The dielectric constant, dielectric loss and AC breakdown strength at the power frequency (50 Hz) of LDPE and LDPE/Acetophenone composites are tested. To explore the underlying mechanism, first principles method and molecular dynamics (MD) simulation are employed to calculate the dipole moment, electron level and electrostatic potential (ESP) distribution of materials in this paper. The experimental and calculation results show that the dielectric constant of the LDPE/Acetophenone composites increases with the increase of acetophenone content because of the newly established dipolar polarization, which originates from the introduction of polar acetophenone. While the AC breakdown strength of the composites decreases obviously as the acetophenone content increases, which is attributed to the low band gap and uneven ESP distribution in them. Our results demonstrate that the existence of acetophenone can lead to the severe degradation of dielectric properties. It provides insight into the quantitative effect of the acetophenone on dielectric properties of LDPE and provides guidance for improving the dielectric properties of XLPE.
Immersion Cooling of Electronics Utilizing Lotus-Type Porous Copper (2016)

This paper evaluates boiling heat transfer performance on a lotus-type porous copper plate attached onto a heated surface. The experiments are performed under atmospheric and saturated pool conditions. The lotus copper plates have uni-directional pore structure in a perpendicular direction for the heated surface and the average hydraulic diameter of the pore hole is 0.36 mm. The lotus copper plate of 1.0 mm or 2.0 mm in thickness is mechanically attached or soldered onto the heated surface in order to obtain the referential boiling heat transfer data of utilizing the lotus copper plate. The boiling curves suggest that the utilization of the lotus copper plate leads to boiling heat transfer enhancement especially in a low heat flux regime even when the lotus copper is mechanically attached to the heat transfer surface. However, the thickness of the lotus plate doesn’t affect the boiling heat transfer in the mechanically attached case, which indicates that there is a big contact thermal resistance between the heated surface and the lotus copper plate. In addition, it is confirmed that the critical heat flux in the mechanically attached case is almost the same as that in the smooth surface case. On the other hand, the critical heat flux increases up to 216 W/cm2 by soldering the lotus copper plate to the heated surface, which is almost double of that in the smooth surface case.
Transradial percutaneous coronary interventions: technique, materials & procedure in the light of anatomical and technical considerations. (2011)

Transradial access is associated with enhanced patients' comfort, significant lower complication rates in diagnostic coronary angiography and better immediate and long-term outcomes after transradial percutaneous coronary interventions. Access failure has been reported to occur in less than 3-7% of cases due to anatomical circumstances (e.g., anomalous radial branching patterns, tortuosity e.g. radial loops, and small radial artery diameters). Radial coronary angiography and angioplasty entail a secondary learning curve of at least 150 cases in order to become familiar and comfortable with this technique. In contrast to previous established techniques (e.g. Sones-arteriotomy), the patient should be positioned in a comfortable supine position with his right arm next to his hip and the interventionist next to the right side of the patient. 19 gauge needles and 0.018 inch wires enhance the chance of successful cannulation the radial artery. A spasmolytic cocktail (3 mg Dinitrate, 3 mg verapamil, at least 3.000 U Heparine) should always be given intraarterially. Longer sheaths (> 13 cm) are not necessary. Essential for easy passage of the vertebralian artery and the common brachio-cephalic trunc (as the most dangerous part of the procedure) in order to reach the ascending aorta, the patient should be asked for a deep inspiration and/or dorsoflexion of his head An Amplatz-II catheter can be used for LCA, RCA and in some cases for LV-angiogram. The sheath should always be removed immediately and hemostasis achieved by radial compression (e.g. clamp). There is a close relationship between access failure respective radial spasm or occlusions and anatomical circumstances (i.e., hypoplastic radial artery, radioulnar loop, or small radial diameters: radial diameter-to-catheter ration < 1.0; assessment by Duplex). Although the radial access can be used in the majority of patients, the use is limited in patients with very small radial diameters and/or with complex lesions (e.g kissing balloon, etc).
Optical Shop Testing (2006)

Fringe scanning techniques, now renamed heterodyning or phase shift interferometry, are covered in a completely rewritten chapter. New chapters have been added to cover wavefront fitting and evaluation as well as holographic and Moire methods. The chapter on parameter measurements has been completely rewritten and an appendix added suggesting appropriate tests for typical optical surfaces.
Transforming growth factor beta decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon gamma. (1990)

Culture of rat islets of Langerhans for 1 week at 37 degrees C with recombinant transforming growth factor beta prolonged the survival of islet xenografts transplanted into diabetic mouse recipients. Treatment of diabetic recipients with a neutralizing monoclonal antibody to murine interferon gamma did not affect the survival of islet xenografts cultured 7 days in control medium. However, treatment of donor islets with transforming growth factor beta in combination with treatment of diabetic recipients with interferon gamma antibody produced a 75% survival of the islet xenografts at 100 days. Fifty percent of the recipients who had accepted their graft for more than 100 days were immune unresponsive to a transplant of freshly isolated islets from the same donor strain.
[Structural studies of veneered palladium alloys with a focus on the ceramometal interface]. (1989)

Samples of palladium-silver and palladium-copper alloys with ceramic veneers were examined under incident light and scanning electron microscopes in terms of their metallographic properties. Both materials showed a fine grain structure. The palladium-silver alloy had inhomogeneous crystallites. The palladium-copper alloy showed several heterogeneous phases. Wavelength dispersive x-ray analysis was used to record concentration profiles and element distribution patterns. An accumulation of nonprecious components and oxygen was observed in the immediate ceramometal interface. Adjacent to this a largely homogeneous zone was visible which is probably due to the diffusion of nonprecious elements during the different stages of baking. The results lead to conclusions concerning the final finishing after application of the ceramic veneer.
Oxidation of Dimethyl Sulfoxide in Aqueous Solution Using Microbubbles (2009)

A large quantity of dimethyl sulfoxide (DMSO) wastewater is discharged from washing and rinsing processes in semiconductor manufacturing industry. Traditional biological treatment is known to be difficult for the treatment of DMSO-containing wastewater because of odor problems. Ozonation of DMSO combined with a biological process is suggested to be a cost-efficient treatment solution, whereas the application of ozone to wastewater treatment has been limited by its low utilization efficiency and high cost. In this study, we applied an ozone microbubble generator to increase ozone transfer efficiency in the aqueous solution. The oxidation of DMSO by ozone microbubbles was investigated in a bubble column reactor with an inner diameter of 20 cm. We studied the dependence of DMSO degradation on the gas and liquid flow rates. Experimental results indicate that the ozonation of DMSO is a first-order mass-transfer-controlled reaction and the reaction rate constant increases with increasing gas velocity. Ozone transfer ratio increases with decrease in gas flow rate.