gebhart/patrepeval huggingface dataset:
Route panoramas for city navigation (2003)

This paper presents a new medium called route panorama (RP) for visualizing a large-scale environment such as a town or a city. An RP is captured by a slit camera mounted on a vehicle. It is a continuous, compact and complete visual representation of scenes along a route. It can be transmitted on the Internet in real time as a streaming media and displayed in various styles for virtual city traversing. The application of RPs includes virtual tour, navigation, heritage archiving, urban planning, city indexing, etc.
Derivatives of 2-azabicyclo[2.2.2]octane. III. Substituted phenylsulfonylureido derivatives (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of 2-azabicyclo[2.2.2]octane. III. Substituted phenylsulfonylureido derivativesFrank J. Villani, Elizabeth A. Wefer, Thomas A. Mann, and Claire A. EllisCite this: J. Med. Chem. 1969, 12, 5, 933–934Publication Date (Print):September 1, 1969Publication History Published online1 May 2002Published inissue 1 September 1969https://pubs.acs.org/doi/10.1021/jm00305a060https://doi.org/10.1021/jm00305a060research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT (2012)

The eukaryotic chaperonin, TRiC/CCT (TRiC, TCP-1 ring complex; CCT, chaperonin containing TCP-1), uses a built-in lid to mediate protein folding in an enclosed central cavity. Recent structural data suggest an effective size limit for the TRiC folding chamber of ∼70 kDa, but numerous chaperonin substrates are substantially larger. Using artificial fusion constructs with actin, an obligate chaperonin substrate, we show that TRiC can mediate folding of large proteins by segmental or domain-wise encapsulation. Single or multiple protein domains up to ∼70 kDa are stably enclosed by stabilizing the ATP-hydrolysis transition state of TRiC. Additional domains, connected by flexible linkers that pass through the central opening of the folding chamber, are excluded and remain accessible to externally added protease. Experiments with the physiological TRiC substrate hSnu114, a 109-kDa multidomain protein, suggest that TRiC has the ability to recognize domain boundaries in partially folded intermediates. In the case of hSnu114, this allows the selective encapsulation of the C-terminal ∼45-kDa domain and segments thereof, presumably reflecting a stepwise folding mechanism. The capacity of the eukaryotic chaperonin to overcome the size limitation of the folding chamber may have facilitated the explosive expansion of the multidomain proteome in eukaryotes.
Isolation of a Campylobacter lanienae-like Bacterium from Laboratory Chinchillas (Chinchilla laniger) (2014)

Routine necropsies of 27 asymptomatic juvenile chinchillas revealed a high prevalence of gastric ulcers with microscopic lymphoplasmacytic gastroenteritis and typhlocolitis. Polymerase chain reaction (PCR) analysis using Campylobacter genus-specific partial 16S rRNA primers revealed the presence of Campylobacter spp. DNA in the faeces of 12 of 27 animals (44.4%). Species-specific partial 16S rRNA PCR and sequencing confirmed that these animals were colonized with Campylobacter lanienae, a gram-negative, microaerophilic bacterium that was first identified on routine faecal screening of slaughterhouse employees and subsequently isolated from faeces of livestock. Campylobacter lanienae was isolated from the faeces of six PCR-positive animals and identified with species-specific PCR and full 16S rRNA sequencing. Phylogenetic analysis showed that these isolates clustered with C. lanienae strain NCTC 13004. PCR analysis of DNA extracted from gastrointestinal tissues revealed the presence of C. lanienae DNA in the caecum and colon of these chinchillas. Gastrointestinal lesions were scored and compared between C. lanienae-positive and C. lanienae-negative animals. There was no correlation between colonization status and lesion severity in the stomach, liver, duodenum, or colon. Possible routes of C. lanienae infection in chinchillas could include waterborne transmission and faecal–oral transmission from wild mice and rats or livestock. Based on these findings, the authors conclude that C. lanienae colonizes the lower bowel of chinchillas in the absence of clinical disease. This is the first report of C. lanienae in any rodent species. Campylobacter lanienae isolates from different mammalian species demonstrate heterogeneity by 16S rRNA sequence comparison. Analysis using rpoB suggests that isolates and clones currently identified as C. lanienae may represent multiple species or subspecies.
Green recyclable SO3H-carbon catalyst for the selective synthesis of isomannide-based fatty acid monoesters as non-ionic bio-surfactants (2015)

Solvent free one-pot synthesis of isomannide-based fatty acid monoesters as non-ionic bio-surfactants employing a green recyclable SO<sub>3</sub>H-carbon catalyst was demonstrated.
P96-T Characterization the Sequence and Post-Translational Modification of Large Peptides by Tandem ETD MS/MS (2007)

Protein/peptide analysis is commonly based on use of a tandem mass spectrometer combining electrospray ionization and collision-induced dissociation (CID). The major disadvantage of collisional ion activation is the internal heating of the parent ion, which predominantly yields cleavages of the weakest bonds, resulting in less informative fragment spectra; this often limits peptide sequence determination. To better elucidate the peptide structure, more selective fragmentation techniques are of huge interest. Electron transfer dissociation (ETD) in a non-linear Paul trap has been introduced as a new fragmentation technique, which avoids internal parent ion heating. Induced by the electron transfer, the intermediate peptide radical cations fragment randomly at each amino acid position of the peptide backbone, which is particularly suitable for the sequence characterization of larger peptides and for post-translational modification (PTM) identification. We investigated the electron transfer dissociation of large peptides using the Bruker HCTultra PTM Discovery System. Multiply charged positive peptide target ions are generated via conventional electrospray or via off-line nanospray. Electron transfer dissociation of larger peptides is done in a non-linear three-dimensional Paul trap, where consecutive trapping of peptide cations as well as reagent anion accumulation is enabled under full automatic software control. Common resonance precursor activation via CID MS/ MS almost always results in poor sequence information if the peptide molecular weight exceeds 3000 Da. ETD MS/MS of the same precursor ion provides much better sequence information. Based on the enhanced resolution of the utilized instrument, since even quadruply charged fragment ions are identified, the entire amino acid sequence is read out of the ETD MS/MS spectrum. Even when larger PTM peptides were investigated under ETD conditions, labile bounded PTMs remain attached to the peptide backbone, and are localized without ambiguity. ETD MS/MS data of larger phosphorylated as well as glycosylated peptides will be presented.
Optical biopsy of breast tissue using differential path-length spectroscopy (2005)

Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the beta-carotene concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue.
Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product (1991)

Abstract We investigated the expression, degree of phosphorylation, and activation of the proto-oncogene c-kit product before and after stimulation with the c-kit ligand in a human factor-dependent myeloid leukemia cell line, MO7E. The culture supernatant of the BALB/3T3 fibroblast cell line, which contains the ligand for the murine c-kit product, was found to stimulate proliferation of the MO7E cell line in a dose-dependent manner. The proliferation was significantly inhibited by a tyrosine kinase inhibitor, genistein. An immunoblot technique with a monoclonal antibody specific for phosphotyrosine, showed that there was rapid, dose-dependent tyrosine-phosphorylation of the c-kit product in response to murine c-kit ligand. Furthermore, the murine c-kit ligand increased autokinase activity of the c-kit product in vitro. Similar results were obtained with human stem cell factor (SCF), a recombinant human ligand for the c-kit product. These results suggest that the phosphorylation and activation of the c-kit product are involved in proliferative signals of some human leukemia cells, as well as of normal hematopoietic cells.
Development and Environmental Applications of a Nitrate Microsensor Based on Doped Polypyrrole Films - eScholarship (2003)

Many studies over the last two decades have employed the pyrrole polymerization processes, including several utilizing polypyrrole (PPY) doping with various ions and the application of these doped polypyrrole films as ion selective electrodes (ISE). This work extends these studies in two directions: 1) miniaturization of an ise for nitrate anions, based on nitrate-doped PPY films on a substrate of 7 um carbon fibers, and 2) application of these PPY(no3-) electrodes to nitrate transport experiments in an intermediate scale physical aquifer model, which is a prototype of environmental (in situ) measurements of nitrate in soils. Successful completion of this project will lead to the deployment of distributed nitrate sensor networks in complex environments, including soils, ground and surface waters.
Sexual behavior of HIV-positive adults not accessing HIV treatment in Mombasa, Kenya: Defining (2012)

Abstract Background HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not receiving ART often fall outside the ambit of prevention programs. There is little information on their sexual risk behaviors. This study in Mombasa Kenya therefore explored sexual behaviors of PLHIV not receiving any HIV treatment. Results Using modified targeted snowball sampling, 698 PLHIV were recruited through community health workers and HIV-positive peer counsellors. Of the 59.2% sexually-active PLHIV, 24.5% reported multiple sexual partners. Of all sexual partners, 10.2% were HIV negative, while 74.5% were of unknown HIV status. Overall, unprotected sex occurred in 52% of sexual partnerships; notably with 32% of HIV-negative partners and 54% of partners of unknown HIV status in the last 6 months. Multivariate analysis, controlling for intra-client clustering, showed non-disclosure of HIV
Synthesis and bioactivity of nobilamide B (2014)

An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. <i>Z</i>-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.
Low-mass ions produced from peptides by high-energy collision-induced dissociation in tandem mass spectrometry (1993)

High-energy collision-induced dissociation (CID) mass spectrometry provides a rapid and sensitive means for determining the primary sequence of peptides. The low-mass region (below mass 300) of a large number of tandem CID spectra of peptides has been analyzed. This mass region contains several types of informative fragment ions, including dipeptide ions, immonium ions, and other related ions. Useful low-mass ions are also present in negative-ion CID spectra. Immonium ions (general structure [H2N=CH-R](+), where R is the amino acid side chain) and related ions characteristic of specific amino acid residues give information as to the presence or absence of these residues in the peptide being analyzed. Tables of observed immonium and reiated ions for the 20 standard amino acids and for a number of modified amino acids are presented. A database consisting of 228 high-energy CID spectra of peptides has been established, and the frequency of occurrence of various ions indicative of specific ammo acid residues has been determined. Two model computer-aided schemes for analysis of the ammo-acid content of unknown peptides have been developed and tested against the database.
Role of 5HT1A Receptors in the Neuroprotective and Behavioral Effects of Cannabidiol in Hypoxic–Ischemic Newborn Piglets (2022)

<b>Background:</b> Hypoxic-ischemic (HI) insults have important deleterious consequences in newborns, including short-term morbidity with neuromotor and cognitive disturbances. Cannabidiol (CBD) has demonstrated robust neuroprotective effects and shows anxiolytic/antidepressant effects as well. These effects are thought to be related to serotonin 5-HT<sub>1A</sub> receptor (5HT<sub>1A</sub>R) activation. We hereby aimed to study the role of 5HT<sub>1A</sub>R in the neuroprotective and behavioral effects of CBD in HI newborn piglets. <b>Methods:</b> 1-day-old piglets submitted to 30 min of hypoxia (FiO2 10%) and bilateral carotid occlusion were then treated daily with vehicle, CBD 1 mg/kg, or CBD with the 5HT<sub>1A</sub>R antagonist WAY 100635 1 mg/kg 72 h post-HI piglets were studied using amplitude-integrated EEG to detect seizures and a neurobehavioral test to detect neuromotor impairments. In addition, behavioral performance including social interaction, playful activity, hyperlocomotion, and motionless periods was assessed. Then, brain damage was assessed using histology (Nissl and TUNEL staining) and biochemistry (proton magnetic resonance spectroscopy studies. <b>Results:</b> HI led to brain damage as assessed by histologic and biochemistry studies, associated with neuromotor impairment and increased seizures. These effects were not observed in HI piglets treated with CBD. These beneficial effects of CBD were not reversed by the 5HT<sub>1A</sub>R antagonist, which is in contrast with previous studies demonstrating that 5HT<sub>1A</sub>R antagonists eliminated CBD neuroprotection as assessed 6 h after HI in piglets. HI led to mood disturbances, with decreased social interaction and playfulness and increased hyperlocomotion. Mood disturbances were not observed in piglets treated with CBD, but in this case, coadministration of the 5HT<sub>1A</sub>R antagonist eliminates the beneficial effects of CBD. <b>Conclusion:</b> CBD prevented HI-induced mood disturbances in newborn piglets by acting on 5HT<sub>1A</sub>R. However, 5HT<sub>1A</sub>R activation seems to be necessary for CBD neuroprotection only in the first hours after HI.
Magnetic properties ofPr0.63Sr0.37MnO3andNd0.7Sr0.3MnO3single crystals (1999)

We investigated dc and ac susceptibilities of ${\mathrm{Pr}}_{0.63}{\mathrm{Sr}}_{0.37}{\mathrm{MnO}}_{3}$ and ${\mathrm{Nd}}_{0.7}{\mathrm{Sr}}_{0.3}{\mathrm{MnO}}_{3}$ single crystals. Surprisingly, real components of the ac susceptibility of both samples are frequency dependent below ${T}_{C},$ indicating competition between ferromagnetic and antiferromagnetic interactions even in the ferromagnetic phase. We also found evidence of rare-earth moment ordering at low temperatures. Our ac susceptibility data suggest strongly that ferromagnetic phases of the two samples are of different nature. By comparing the resistivity data with the susceptibility results near ${T}_{C},$ we propose that the order parameter of magnetic origin should be coupled to the other degrees of freedom in the case of ${\mathrm{Nd}}_{0.7}{\mathrm{Sr}}_{0.3}{\mathrm{MnO}}_{3}.$
Public Employees Confront The Perils of Privatization (1999)

When free‐market zealots succeed in turning over government services to profit‐making corporations, workers and citizens often suffer.
Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Characteristics in a Rapidly Progressing Form of Geographic Atrophy (2011)

Patients with the rapidly progressing diffuse-trickling GA phenotype exhibited a characteristic marked separation within the RPE/BM complex on SD-OCT-imaging. The presumed histopathologic correlates are basal laminar deposits. Such deposits may promote RPE cell death and, thus, contribute to rapid GA progression. The persistence of these deposits within the atrophic lesion may account for the distinct grayish FAF appearance, which differs from the markedly reduced signal in other forms of GA. Identification of such alterations based on FAF and SD-OCT imaging may be helpful in future interventional trials directed toward slowing GA progression. (ClinicalTrials.gov number, NCT00393692.).
Collaborative Fashion Recommendation (2015)

With the rapid expansion of online shopping for fashion products, effective fashion recommendation has become an increasingly important problem. In this work, we study the problem of personalized outfit recommendation, i.e. automatically suggesting outfits to users that fit their personal fashion preferences. Unlike existing recommendation systems that usually recommend individual items, we suggest sets of items, which interact with each other, to users. We propose a functional tensor factorization method to model the interactions between user and fashion items. To effectively utilize the multi-modal features of the fashion items, we use a gradient boosting based method to learn nonlinear functions to map the feature vectors from the feature space into some low dimensional latent space. The effectiveness of the proposed algorithm is validated through extensive experiments on real world user data from a popular fashion-focused social network.
In Vitro Characterization of Two Different Ultrasmall Iron Oxide Particles for Magnetic Resonance Cell Tracking (2002)

Citrate-coated USPIO particles VSOP-C125 appear to have more favorable properties for magnetic labeling of macrophages than the carboxydextran-coated USPIO preparation DDM 43/34/103.
Preparation of [carboxy‐13C]4‐nitrophenylacetic acid (2005)

Abstract Reaction of sodium [ 13 C]cyanide with excess benzyl chloride gave ∼75% utilization of the isotope. Subsequent nitration, isomer separation and hydrolysis of the nitrile gave the required carboxy‐labelled 4‐nitrophenylacetic acid. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Estetrol review: profile and potential clinical applications (2008)

In this review paper, the existing information on the human fetal steroid estetrol (E4) has been summarized. In the past, E4 was considered as a weak estrogen and interest disappeared. However, recent new research has demonstrated that E4 is a potent, orally bioavailable, natural human fetal selective estrogen receptor modulator, since it acts in the rat as an estrogen on all tissues investigated except breast tumor tissue, where it has estrogen antagonistic properties in the presence of estradiol. Based on its safety data, its pharmacokinetic properties, its pharmacological profile and the results of first human studies, E4 may be suitable as a potential drug for human use in applications such as hormone replacement therapy (vaginal atrophy, hot flushes), contraception and osteoporosis. Additional areas worth exploring are the treatment of breast and prostate cancer, hypoactive sexual desire disorder and topical use (wrinkles) in women, auto-immune diseases, migraine, cardiovascular applications and the treatment of selected obstetric disorders.
Power Line Communication in dc-dc Converters using Switching Frequency Modulation (2006)

This paper investigates power line communication in digitally-controlled dc-dc converters. Communication between different dc-dc converters is obtained detecting the switching signal on the common bus voltage and using switching frequency modulation. Each converter operates at three different switching frequencies, the first associated to bit 1 transmission, the second to bit 0 transmission and the third associated to no transmission state. Simulation and experimental results on a 3.3 V-10 A dc-dc buck converter, where the communication architecture has been implemented in FPGA, confirm the proposed analysis and the performance achievable by the proposed power line communication techniques. For nominal switching frequency of 200 kHz, the maximum achievable baud rate in our experimental prototype is 8 kbit/s.
Perception and Neuroscience (1989)

Perception is often analysed as a process in which causal events from the environment act on a subject to produce states in the mind or brain. The role of the subject is an increasing feature of neuroscientific and cognitive literature. This feature is linked to the need for an account of the normative aspects of perceptual competence. A holographic model is offered in which objects are presented to the subject classified according to rules governing concepts and encoded in brain function in that form. This implies that the analysis of perception must consider not only the fact that there is an interaction between the perceiving subject and the perceived object but also that the interaction is shaped by a system of concepts which the subject uses in thought and action.
Mesomorphic polyacrylates containing isomeric methyl‐substituted azobenzene mesogens (1991)

Abstract The synthesis and characterization are reported of two new series of structurally isomeric polyacrylates containing the azobenzene moiety spaced away from the backbone by a hexamethylene spacer and substituted in 4‐position with linear alkoxy groups (C 1 C 6 , C 10 ) and with a lateral methyl group in 2′‐ or 3′‐position. Thermal optical and X‐ray analyses of the prepared polymer samples, with molecular weight ranging from 50 × 10 3 to 35 × 10 4 Dalton ( M̄ w /M̄ n = 2−3), provide evidences for the establishment of liquid crystalline behavior in the melt in a fairly broad range of temperature. In any case, quenching from the mesophase allows for the lock‐in of the liquid crystalline structure in the glassy state. The presence of the lateral methyl‐substitutents causes a drop as high as 50–100 K. in the stability of the mesophase with respect to the corresponding samples of the methyl‐unsubstituted series. A parallel depletion of the smectogenic character is also observed. Typical even‐odd effects on the isotropization temperature and relevant thermodynamic parameters have been detected along with the formation of interdigitated smectic structures.