gebhart/patrepeval huggingface dataset:
Der Einfluß der Doppelbindung in organischen Lösungsmitteln auf das Wachstum von Bakterien (1969)

Abstract Es wurden drei ungesättigte und die ihnen entsprechenden gesättigten Lösungsmittel auf ihre antibakterielle Wirkung gegenüber S. aureus, E. coli, Kl. pneumoniae und Ps. aeruginosa untersucht. Die Einführung der Doppelbindung führt zu einer Steigerung der antibakteriellen Wirkung, so daß ungesättigte Lösungsmittel für den Einsatz als Lösungsvermittler bei Resistenzbestimmungen von Bakterien gegenüber in Wasser schwer löslichen Chemotherapeutika nicht in Frage kommen Frl. R. Niederschuh sei an dieser Stelle für exakte und zuverlässige Assistenz herzlichst gedankt.
Antimicrobial Resistance (1997)

Antimicrobial resistance has become an issue of global proportion, and this dilemma has greatly affected the intensive care unit (ICU) setting. Increased antimicrobial use and other selective pressures have created an environment in the ICU that is a testing ground for survival of microorganisms. By various mechanisms, gram-positive cocci and gram-negative bacilli are becoming more resistant to our current armamentarium of antimicrobials. Strategies to improve the current situation of reduced microbial susceptibility include the following: continued and specific surveillance in ICUs, antimicrobial protocols, continued isolation precautions and appropriate handwashing, increased education at all levels, increased use of immunotherapies, better use of our current antimicrobial agents, and increased research in finding new and innovative antimicrobial agents while curtailing the marketing ploys that promote excessive and inappropriate use of these valuable medications.
Comparison of different strategies for controlling HIV/AIDS spreading in MSM (2018)

As proposed in the UNAIDSs 2014 report, to end global AIDS epidemic by 2030, 90% of people living with HIV need to be diagnosed, 90% of the diagnosed need to receive antiretroviral therapy (ART), and 90% of those on treatment need to achieve viral suppression (90-90-90 strategy). The strategies focus on the reservoir. It controls HIV spreading by reducing infectiousness of HIV infected individuals via diagnosis and treatment. In this manuscript, we compared the effects of HIV/AIDS interventions that focus on different individuals in MSM population through a dynamics model. Our results showed that, the success or not of the "90-90-90" strategies depends on a very important factor: the infectious strength among individuals taking ART. Without highly effective HIV treatment, the "90-90-90" strategies are likely to fail. Therefore, we call for the combination of both primary prevention among the susceptible with the 90-90-90 strategy among the infected to curb the HIV epidemic in Chinese MSM.
The Composition of Cigarette Smoke. V. Solanesenes (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Composition of Cigarette Smoke. V. SolanesenesALAN RODGMAN, LAWRENCE C. COOK, and SAM S. MIMSCite this: J. Org. Chem. 1961, 26, 2, 497–501Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/jo01061a051https://doi.org/10.1021/jo01061a051research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactive Body-Driven Graphics for Augmented Video Performance (2019)

We present a system that augments live presentation videos with interactive graphics to create a powerful and expressive storytelling environment. Using our system, the presenter interacts with the graphical elements in real-time with gestures and postures, thus leveraging our innate, everyday skills to enhance our communication capabilities with the audience. However, crafting such an interactive and expressive performance typically requires programming, or highly-specialized tools tailored for experts. Our core contribution is a flexible, direct manipulation UI which enables amateurs and experts to craft such presentations beforehand by mapping a variety of body movements to a wide range of graphical manipulations. By simplifying the mapping between gestures, postures, and their corresponding output effects, our UI enables users to craft customized, rich interactions with the graphical elements. Our user study demonstrates the potential usage and unique affordance of this mixed-reality medium for storytelling and presentation across a range of application domains.
Critical microjets in collapsing cavities (1995)

Inward microjets are commonly observed in collapsing cavities, but here we show that jets with exceptionally high velocities and accelerations occur in certain critical flows dividing jet formation from bubble pinch-off. An example of the phenomenon occurs in the family of flows which evolve from a certain class of initial conditions: the initial flow field is that due to a moving point sink within the cavity. A numerical study of the critical flow shows that in the neighbourhood of microjet formation the flow is self-similar. The local accelerations, velocities and distances scale as t β-2 , t β-1 and t β respectively, where β = 0.575. The velocity potential is approximately a spherical harmonic of degree ¼.
A Systematic Review and Meta-Analysis of Variant Histology in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy (2020)

Variant histology in patients with urothelial carcinoma of the bladder is associated with increased risks of disease recurrence as well as cancer specific and overall mortality. Variant histology was independently associated with overall survival in the "micropapillary," "plasmacytoid" and "small cell" subgroups. Variant histology should be integrated into prognostic tools to guide risk stratification, treatment planning and patient counseling. However, caution should be exercised in interpreting the conclusions drawn from this study given the limitations, which include the heterogeneity of the population of interest and the retrospective nature of the primary data evaluated.
Early detection of amyloid load using 18F-florbetaben PET (2021)

Data used in this manuscript belong to clinical trials registered in ClinicalTrials.gov ( NCT00928304 , NCT00750282 , NCT01138111 , NCT02854033 ) and EudraCT (2014-000798-38).
Assessment of Vasculature Using Combined MRI and MR Angiography (2004)

Combined cine gradient-recalled echo MRI and MR angiography is a reliable method for imaging pulmonary vascular supply in patients with these disorders. Additional prospective studies comparing MRI and conventional angiography may determine whether routine preoperative conventional angiography is required.
PARAMETRIC STUDY OF MACHINE FOUNDATION SUPPORTING RECIPROCATING MACHINE USING ELASTIC HALF SPACE MODEL BY FEM AND CLASSICAL METHOD (2021)

Machine foundation is a requisite part of any industry; costs less as compared to the cost of machine and losses caused due to its failure can cause a big loss to any industry. A machine foundation needs to be designed carefully as static as well as dynamic loads are acting on it due to working of machine. The machine weighs several tons and is required to design the foundations having dimensions of several meters but amplitudes restricted to only a few microns. In addition, natural frequency of the machine foundation is depends on the soil lying below the foundation. This necessitated a deeper scientific investigation of dynamic loading and analysis. Elastic Half Space Method (Recommended by ACI 351.3R-04 “Foundation for Dynamic Equipment”) proposed by Whitman and Richart gives thus necessary importance to damping and embedment depth effect. Finite Element (FE) is the most commonly accepted analysis tool for solution of engineering problems. Effective Pre &amp; Post-processing capabilities make modeling and interpretation of results simple. It is relatively easy to incorporate changes if any and re-do the analysis without much loss of time. STAAD Pro V8i is chosen for this Literature for analysis of Machine Foundation by Finite Element Method. In this literature three different machines of 150 rpm, 250 rpm, and 450 rpm are taken into account and six different soil types: Medium Clay, Stiff Clay, Hard Clay, Loose Sand, Medium Sand and Dense Sand are considered. Foundation sizes are optimized according to soil cases and each case is analyzed using classical method and FEM for 0.8, 1 and 1.2 times the soil parameters to cover the confidence range. Codal Criteria are taken as per IS:2974-1982.
Antibody-mediated protection against symptomatic COVID-19 can be achieved at low serum neutralizing titers (2023)

Multiple studies of vaccinated and convalescent cohorts have demonstrated that serum neutralizing antibody (nAb) titers correlate with protection against coronavirus disease 2019 (COVID-19). However, the induction of multiple layers of immunity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure has complicated the establishment of nAbs as a mechanistic correlate of protection (CoP) and hindered the definition of a protective nAb threshold. Here, we show that a half-life-extended monoclonal antibody (adintrevimab) provides about 50% protection against symptomatic COVID-19 in SARS-CoV-2-naïve adults at serum nAb titers on the order of 1:30. Vaccine modeling results support a similar 50% protective nAb threshold, suggesting that low titers of serum nAbs protect in both passive antibody prophylaxis and vaccination settings. Extrapolation of adintrevimab pharmacokinetic data suggests that protection against susceptible variants could be maintained for about 3 years. The results provide a benchmark for the selection of next-generation vaccine candidates and support the use of broad, long-acting monoclonal antibodies as alternatives or supplements to vaccination in high-risk populations.
On the Summarization of Dynamically Introduced Information: Online Discussions and Blogs. (2006)

{liangz, hovy} @ isi.edu In this paper we describe computational approaches to summarizing dynamically introduced information: online discussions and blogs, and their evaluations. Research in the past has been mainly focused on text-based summarization where the input data is predominantly newswire data. When branching into these newly emerged data types, we face number of difficulties that are discussed here.
Use of X-Ray Fluorescence Microscopy for Studies on Research Models of Hepatocellular Carcinoma (2021)

<b>Introduction:</b> TheraSphere<sup>®</sup> microspheres containing yttrium <sup>90</sup>Y are among many radioembolization agents used clinically to reduce liver tumor burden, and their effects on cancer volume reduction are well-established. At the same time, concerns about off target tissue injury often limit their use. Deeper investigation into tissue distribution and long-term impact of these microspheres could inform us about additional ways to use them in practice. <b>Methods:</b> Healthy rat liver and rabbit liver tumor samples from animals treated with TheraSpheres were sectioned and their elemental maps were generated by X-ray fluorescence microscopy (XFM) at the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory (ANL). <b>Results:</b> Elemental imaging allowed us to identify the presence and distribution of TheraSpheres in animal tissues without the need for additional sample manipulation or staining. Ionizing radiation produced by <sup>90</sup>Y radioactive contaminants present in these microspheres makes processing TheraSphere treated samples complex. Accumulation of microspheres in macrophages was observed. <b>Conclusions:</b> This is the first study that used XFM to evaluate the location of microspheres and radionuclides in animal liver and tumor samples introduced through radioembolization. XFM has shown promise in expanding our understanding of radioembolization and could be used for investigation of human patient samples in the future.
TAIWAN'S INTEGRATING SURVEILLANCE, EPIDEMIOLOGICAL DISCOVERIES, AND PUBLIC HEALTH POLICIES CAN GUIDE GLOBAL PREVENTION AND CONTROL OF DENGUE (2023)

Intro: Severe outbreaks in Taiwan during 1987-2015 had always started from failure in detecting early dengue cases. However, the extreme low numbers of indigenous dengue cases in southern Taiwan during 2016-2022 have been succeeded with early efforts through integrated surveillance systems, including, free charge NS1 screening of virological surveillance for patients with dengue-like illness, fever surveillance at the airport and entomological surveillance looking for mosquito breeding sites. Recently, we used machine learning models to assist in finding lab.-confirmed dengue cases and predicting severe dengue cases in the elderly. Methods: We investigated factors that were associated with severe dengue outbreaks in southern Taiwan and used geographical information system (GIS) to plot spatial distribution of laboratory-confirmed dengue cases. Findings: Six epidemiological findings can direct prevention and control policies. (1) The onset of epidemics begins with imported dengue cases and appropriate weather conditions (high temperature, low humidity) enlightening to educate the symptoms/signs of dengue for travelers is important. (2) DENV-2, had resulted in most severe epidemics. (3) Once DENV- 2/DENV-3 circulates too long or severe cases occur, fatal dengue cases will increase alongside the prolongation of epidemic wave. (4) In areas with high population densities, either longer epidemic wave or higher transmission intensity can result in greater percentage of severe dengue cases. However, in areas with low population densities, both conditions can lead to greater percentage of severe dengue cases Therefore., interrupting DENV transmission efficiently can reduce severe/fatal cases. (5) Severe dengue cases frequently occur in tempo-spatial dengue clusters implying the importance to find out the sources of infection. The overlapping areas between high mosquito indices and dengue clusters facilitate transmission persistence. (6) Source reduction is more effective than insecticide-spraying. Conclusion: integrated surveillance systems, immediate interrupting transmission, and identifying mosquito breeding sites all together can reduce epidemic severity and thus promoting global health.
PDGFRα Expression During Mouse Embryogenesis: Immunolocalization Analyzed by Whole-mount Immunohistostaining Using the Monoclonal Anti-mouse PDGFRα Antibody APA5 (1997)

We investigated the cells that express platelet-derived growth factor receptor alpha (PDGFR alpha) during mouse embryogenesis. PDGFR alpha expression has been identified by in situ hybridization or immunohistochemistry using polyclonal antibodies on tissue sectins. Because no immunostaining study using whole-mount specimens has been published to date, we established a new monoclonal antibody (MAb), APA5, for this purpose. Our results differed in that APA5 stained only the paraxial mesoderm, whereas other investigators concluded that most if not all mesodermal cells expressed PDGFR alpha. Moreover, we did not find PDGFR alpha expression in embryonic erythrocytes, which have been previously suggested to express PDGFR alpha. On the basis of our present results, we wish to revise the proposed PDGFR alpha expression as follows. At the pregastrulation stage, PDGFR alpha is expressed only in primitive endoderm, particularly that in the ectoplacental cone. On gastrulation, it is expressed at high levels in the paraxial mesoderm. This expression continues after its differentiation into the somite. Along with the differentiation and migration of the sclerotome, PDGFR alpha + cells begin to become distributed throughout the embryonal mesenchyme. During organogenesis, particularly intense staining is detected in regions of epithelial and mesenchymal interaction, such as the tooth bud and bronchi. In addition to mesodermal derivatives, the developing lens, apical ectodermal ridge, glial precursor, cardiac valves, and choroid plexus express PDGFR alpha. Our results with whole-mount immunostaining show that PDGFR alpha is abundantly expressed and may play important roles during embryogenesis.
Silk fibroin-based Nanotherapeutics: Application in the Treatment of Colonic Diseases (2019)

The incidence of colonic diseases (e.g., inflammatory bowel diseases and colon cancer) is rapidly rising. Nanotherapeutic has been considered as a promising strategy in the treatment of colonic diseases. Silk fibroin (SF) has been widely used as a drug-carrier matrix. Interestingly, SF-based nanoparticles (SFNPs) have intrinsic anti-inflammatory activity, wound healing capacity and lysosomal environment-responsive drug-release property. With further investigations, the sequences of SF molecules could be precisely modified through chemical reactions or transgenic techniques to greatly improve the properties of SFNPs. Here, we review recent advances in the application of SFNPs toward the treatment of colonic diseases. We also discuss future developments that might improve the anti-inflammatory and anti-colon cancer activities of SF-based nanotherapeutics.
Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells. (1989)

The purpose of this study was to compare the toxicity, immunomodulatory changes, and antitumor efficacy of interleukin 2 (IL-2) and lymphokine activated killer (LAK) cell therapy with two durations of IL-2 infusion. Patients with progressive melanoma, non-Hodgkin's lymphoma, renal carcinoma, or colon carcinoma received IL-2 at 3 X 10(6) units/m2/day on days 1-5 and 13-17, either by bolus injection every 8 h (q8h) or by continuous i.v. (CIV) administration. Peripheral blood mononuclear cells were harvested by leukapheresis on days 8, 9, and 10, were incubated in vitro for 5 days for generation of LAK cells, and were infused on days 13, 14, and 15. The first 11 patients were treated with IL-2 q8h, and the subsequent 13 patients were treated by CIV infusion. Toxicity consisted primarily of fever, chills, emesis, diarrhea, weight gain, and edema but did not require intensive care unit support and did not differ significantly between treatment groups. IL-2-induced lymphocytosis on day 8 was higher with CIV than with q8h administration with a mean lymphocyte count/microliter of 5610 +/- 700 (SE) versus 3300 +/- 500. Immunomodulatory changes observed on days 8 and 20 were also greater with CIV IL-2 and included an increase in peripheral blood mononuclear cell IL-2 receptor expression as well as a marked rise in the number of Leu-11+ and Leu-19+ peripheral blood mononuclear cells. The total leukapheresis yield per patient and total number of LAK cells infused per patient were higher with CIV than q8h administration, with 49.8 +/- 4.9 X 10(9) versus 39.4 +/- 5.4 X 10(9) and 42.6 +/- 5.0 X 10(9) versus 34.0 +/- 5.4 X 10(9), respectively. The cells infused displayed phenotypic evidence of activation and exhibited marked lytic reactivity to Daudi, Raji, and HT-144 targets. One complete and one minimal response were observed in 2 of 8 patients with metastatic renal cell carcinoma who received CIV IL-2 and LAK cells. The results show that IL-2 is more biologically active by CIV than q8h administration, as demonstrated by greater rebound lymphocytosis, LAK cell yield, and in vivo immunostimulation.
Tau Imaging in the 4-Repeat-Tauopathies Progressive Supranuclear Palsy and Corticobasal Syndrome (2020)

In line with known neuropathological changes, the spatial pattern and magnitude of C-PBB3 tau binding differ between CBS, PSP, and AD, which may be of diagnostic utility. Thus, C-PBB3 offers a promising lead structure for development of ligands for tau imaging, including 4R-tauopathies.
Variable presence of KITD816V in clonal haematological non‐mast cell lineage diseases associated with systemic mastocytosis (SM–AHNMD) (2009)

In a substantial number of patients with systemic mastocytosis (SM), an associated clonal haematological non-mast cell lineage disease (AHNMD) is detectable. Although most of these patients display KIT mutations, especially KIT(D816V), little is known about their exact frequency and their distribution in AHNMD subtypes. We examined 48 patients with SM-AHNMD for the presence of mutant KIT in the SM and AHNMD components of the disease. Mast cells and AHNMD cells were obtained from immunostained bone marrow sections by laser microdissection and examined by melting point analysis of nested-PCR products. KIT(D816V) was found in AHNMD cells in the vast majority of patients with SM-chronic myelomonocytic leukaemia (CMML, 89%). Unexpectedly, KIT(D816V) was far less frequently detectable in AHNMD cells in patients with SM-myeloproliferative neoplasm (MPN, 20%) and SM-acute myeloid leukaemia (AML, 30%). None of the patients with lymphoproliferative AHNMDs displayed KIT codon 816 mutations in AHNMD cells (0/8). In FIP1L1/PDGFRA-positive chronic eosinophilic leukaemia (CEL), neither the SM nor the CEL component of the disease exhibited the KIT mutation. Our findings demonstrate that KIT codon 816 mutations are variably present in AHNMD cells in patients with SM-AHNMD, depending on the subtype of AHNMD. The high frequency of KIT(D816V) in neoplastic mast cells and leukaemic myelomonocytic cells in SM-CMML may point to a common precursor in these patients, and may have implications for the biology of the disease and the development of KIT-targeting therapies.
A Simulation Tool for Analysis of Oscillator Ensembles Defined by Kuramoto Model (2020)

The paper proposes a tool for the numerical simulation of the behavior of coupled oscillators based on Kuramoto model. The approach is based on constructing electrical circuit model for which Kirchhoff equations coincide with Kuramoto equations of the oscillator ensemble. A procedure to generate Spice netlist for the circuit has been developed. The procedure is based on the initial description of the Kuramoto model in the form of Matlab data structures.
Characterization of prothymocytes with cloning capacity in human bone marrow (1988)

The identity of human bone marrow (BM)-derived T cell precursors with colony forming capacity has led to controversy because of contamination with mature clonogenic T cells. We achieved 2 Log elimination of mature T cells from BM using a cocktail of monoclonal antibodies: CD2, CD3, CD4, CD6, and CD8 followed by two successive baby rabbit C' treatment. T cell depleted BM can generate colonies of CD2+, CD3+, Ti+, mostly CD4+, in the presence of PHA, rIL2, and a prothymocyte differentiating activity derived from phytohemagglutinin (PHA) induced mononuclear cells. These precursors could be enriched three- to sixfold by percoll gradient centrifugation and then significantly bypass the number of contaminant mature T cells as shown by limiting dilution analysis. Colony generation by marrow precursors was inhibited by the addition of autologous T cells. This inhibition was mostly caused by the T8+ subset. CFU-TL growth was dramatically inhibited by eliminating CD7+ cells suggesting their positivity for this surface marker. These precursors needed major histocompatibility complex (MHC) II-positive cells for optimal growth but lack DR themselves.