gebhart/patrepeval huggingface dataset:
Functionalized Hydrophilic Superparamagnetic Iron Oxide Nanoparticles for Magnetic Fluid Hyperthermia Application in Liver Cancer Treatment (2018)

In this work, we report the synthesis of hydrophilic and surface-functionalized superparamagnetic iron oxide nanoparticles (SPIOs) to utilize them as nanomedicines for treating liver cancer via magnetic fluid hyperthermia (MFH)-based thermotherapy. For this purpose, initially, we have synthesized the SPIOs through co-precipitation/thermolysis methods, followed by in situ surface functionalization with short-chained molecules, such as 1,4-diaminobenzene (14DAB), 4-aminobenzoic acid (4ABA) and 3,4-diaminobenzoic acid (34DABA) and their combination with terephthalic acid (TA)/2-aminoterephthalic acid (ATA)/trimesic acid (TMA)/pyromellitic acid (PMA) molecules. The as-prepared SPIOs are investigated for their structure, morphology, water dispersibility, and magnetic properties. The heating efficacies of the SPIOs are studied in calorimetric MFH (C-MFH) with respect to their concentrations, surface coatings, dispersion medium, and applied alternating magnetic fields (AMFs). Although all of the as-prepared SPIOs have exhibited superparamagnetic behavior, only 14DAB-, 4ABA-, 34DABA-, and 4ABA-TA-coated SPIOs have shown higher magnetization values (<i>M</i><sub>s</sub> = 55-71 emu g<sup>-1</sup>) and good water dispersibility. In C-MFH studies, 34DABA-coated SPIO-based aqueous ferrofluid (AFF) has revealed faster thermal response to the applied AMF and reached therapeutic temperature even at the lowest concentration (0.5 mg mL<sup>-1</sup>) compared with 14DAB-, 4ABA-, and 4ABA-TA-coated SPIO-based AFFs. Moreover, 34DABA-coated SPIO-based AFF has exhibited high heating efficacies (i.e., specific absorption rate/intrinsic loss power values of 432.1 W g<sub>Fe</sub><sup>-1</sup>/5.2 nHm<sup>2</sup> kg<sup>-1</sup> at 0.5 mg mL<sup>-1</sup>), which could be mainly due to (i) enhanced π-π conjugation paths of surface-attached 34DABA coating molecules because of intrafunctional group attractions and (ii) improved anisotropy from the formation of clusters/linear chains of the SPIOs in ferrofluid suspensions, owing to interfunctional group attractions/interparticle interactions. Moreover, the 34DABA-coated SPIOs have demonstrated (i) very good cytocompatibility for 24/48 h incubation periods and (ii) higher killing efficiency of 61-88% (via MFH) in HepG2 liver cancer cells as compared to their treatment with only AMF/water-bath-based thermotherapy. In summary, the 34DABA-coated SPIOs are very promising heat-inducing agents for MFH-based thermotherapy and thus could be used as effective nanomedicines for cancer treatments.
A Comparison of Strategies for Retinopathy of Prematurity Detection (2015)

Although digital imaging decreased the number of ROP examinations per infant, there was an increase in the total number of interventions (ie, ROP examinations and imaging sessions). Providing an ROP examination at the time of NICU discharge can significantly reduce the number of infants who require follow-up.
Modified theory of three-channel Kerr-type nonlinear directional coupler (1992)

We point out inconsistencies in previous analyses of multiple-channel nonlinear directional couplers based on Kerr-type media and present a modified set of coupled-mode equations for a three-channel nonlinear coupler that indicate a mode of power switching between channels with increased input power that is both qualitatively and quantitatively different from that predicted previously.
The MEMS FTIR spectrometer: An optical IC to analyze everywhere (2016)

Summary form only given, as follows. The complete presentation was not made available for publication as part of the conference proceedings. Optical spectrometers are key instruments in all the material labs for the analysis and identifications of different material compositions. They are also necessary for many other applications like: channel monitoring in optical telecommunications, gas sensing, pharmaceutical analysis …etc. The wide spread of the spectrometer use in different applications is based on the fact that each material has its own signature in the spectral domain and this signature or figure print is based on its composition. Transforming this bench top instrument into a tiny sensor with small size, weight, and low cost can open the door for enormous applications in the market especially in food industry, health care monitoring, soil analysis, oil and gas industry and so on. There exists different techniques for building a miniaturized optical spectrometers and each technique has its own merits and limitations. The MEMS technology is one of the most promising techniques as it enables the integration of different functions on a single chip using the IC technology. In the last decade, many successful trials have been demonstrated in the literature on both the lab and the industrial levels. The real challenge is to achieve the small integrated scalable spectrometer without scarifying the high performance required in the different applications. This talk will address the current status as well as the potential of the newly developed monolithic integrated optical spectrometer on a Si substrate. The talk will be focusing on the development using the Deep Reactive Ion Etching DRIE technology to creat an integrated optical spectrometer with high performance. The different structures and technical challenges faced in this direction will be analyzed to assess the potentials and limitations facing this dream of a monolithic optical IC spectrometer from both the industrial and academic points of view.
Unlocking Ordered Parallelism with the Swarm Architecture (2016)

The authors present Swarm, a parallel architecture that exploits ordered parallelism, which is abundant but hard to mine with current software and hardware techniques. Swarm programs consist of short tasks, as small as tens of instructions each, with programmer-specified order constraints. Swarm executes tasks speculatively and out of order and efficiently speculates thousands of tasks ahead of the earliest active task to uncover enough parallelism. Several techniques allow Swarm to scale to large core counts and speculation windows. The authors evaluate Swarm on graph analytics, simulation, and database benchmarks. At 64 cores, Swarm outperforms sequential implementations of these algorithms by 43 to 117 times and state-of-the-art software-only parallel algorithms by 3 to 18 times. Besides achieving near-linear scalability, Swarm programs are almost as simple as their sequential counterparts, because they do not use explicit synchronization.
Autoradiographic localization and biochemical characteristics of M1 and M2 muscarinic binding sites in the striatum of the cat, monkey, and human (1988)

The autoradiographic distribution of M1 and M2 muscarinic cholinergic binding sites was studied in the striatum of the cat, monkey, and human, and concurrent binding assays were carried out on striatal tissue sections from the cat. M1 sites were directly labeled with 3H-pirenzepine; M2 sites were labeled as a consequence of binding competition between pirenzepine and 3H-N-methylscopolamine. Serial section analysis with autoradiograms and stained tissue sections allowed for comparisons among M1 and M2 binding distributions and AChE staining patterns. The 2 subtypes of binding sites demonstrated distinct striatal distributions. M2 sites were virtually homogeneous except in the ventral striatum, where zones of sparse and especially dense binding were observed. Striatal M1 sites were generally more abundant than M2 sites and showed similar heterogeneity in the ventral striatum. Dorsally, however, patches of dense M1 binding were found, and proved to correspond with AChE-poor striosomes, hallmarks of striatal compartmentalization. The finding of differing distributions for the 2 subtypes of muscarinic cholinergic binding sites suggests a mechanism for the intrinsic spatial segregation of striatal cholinergic function. Further, the striosomal patterning of M1 binding indicates that certain aspects of cholinergic function in the striatum may be constrained and thus regulated by the compartmental ordering characteristic of this region of the basal ganglia.
A dynamic programming approach for constrained multi-stage problems via multi-parametric programming (2007)

This paper presents a new algorithm for multi-stage decision problems with hard constraints. The algorithm is based upon the concepts of dynamic programming and multi-parametric programming. The multi-stage problem is considered within a framework of dynamic programming where each echelon of problem is formulated and solved as a multi-parametric program. The state-space of a given stage constitutes the parametric space whereas the state-space of the next stage represents the space of control or optimisation variables. The solution of the resulting multi-parametric program is given by the control or the optimization variables as a set of explicit functions of the parameters. The dynamic recursive nature of the multi-stage problem is preserved and a set of sequential and simpler multi-parametric programs which are constrained by a reduced number of inequalities is obtained. This results in a reduction in the complexity of the overall problem. The underlying theory is described in detail and numerical examples are presented to illustrate the potential of this new approach.
VisualWordGrid: Information Extraction From Scanned Documents Using A\n Multimodal Approach (2020)

We introduce a novel approach for scanned document representation to perform\nfield extraction. It allows the simultaneous encoding of the textual, visual\nand layout information in a 3-axis tensor used as an input to a segmentation\nmodel. We improve the recent Chargrid and Wordgrid \\cite{chargrid} models in\nseveral ways, first by taking into account the visual modality, then by\nboosting its robustness in regards to small datasets while keeping the\ninference time low. Our approach is tested on public and private document-image\ndatasets, showing higher performances compared to the recent state-of-the-art\nmethods.\n
Supplementary Figure S2 from Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs (2023)

&lt;p&gt;S2. In vitro killing of IFNγ treated B16-ova cells by activated OT-I T cells is inhibited by PD-L1.&lt;/p&gt;
vChain: Enabling Verifiable Boolean Range Queries over Blockchain Databases (2018)

Blockchains have recently been under the spotlight due to the boom of cryptocurrencies and decentralized applications. There is an increasing demand for querying the data stored in a blockchain database. To ensure query integrity, the user can maintain the entire blockchain database and query the data locally. However, this approach is not economic, if not infeasible, because of the blockchain's huge data size and considerable maintenance costs. In this paper, we take the first step toward investigating the problem of verifiable query processing over blockchain databases. We propose a novel framework, called vChain, that alleviates the storage and computing costs of the user and employs verifiable queries to guarantee the results' integrity. To support verifiable Boolean range queries, we propose an accumulator-based authenticated data structure that enables dynamic aggregation over arbitrary query attributes. Two new indexes are further developed to aggregate intra-block and inter-block data records for efficient query verification. We also propose an inverted prefix tree structure to accelerate the processing of a large number of subscription queries simultaneously. Security analysis and empirical study validate the robustness and practicality of the proposed techniques.
Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils (2013)

Methicillin-resistant Staphylococcus aureus (MRSA) strains of the pulsed-field type USA300 are primarily responsible for the current community-associated epidemic of MRSA infections in the United States. The success of USA300 is partly attributed to the ability of the pathogen to avoid destruction by human neutrophils (polymorphonuclear leukocytes [PMNs]), which are crucial to the host immune response to S. aureus infection. In this work, we investigated the contribution of bicomponent pore-forming toxins to the ability of USA300 to withstand attack from primary human PMNs. We demonstrate that in vitro growth conditions influence the expression, production, and availability of leukotoxins by USA300, which in turn impact the cytotoxic potential of this clone toward PMNs. Interestingly, we also found that upon exposure to PMNs, USA300 preferentially activates the promoter of the lukAB operon, which encodes the recently identified leukocidin AB (LukAB). LukAB elaborated by extracellular S. aureus forms pores in the plasma membrane of PMNs, leading to PMN lysis, highlighting a contribution of LukAB to USA300 virulence. We now show that LukAB also facilitates the escape of bacteria engulfed within PMNs, in turn enabling the replication and outgrowth of S. aureus. Together, these results suggest that upon encountering PMNs S. aureus induces the production of LukAB, which serves as an extra- and intracellular weapon to protect the bacterium from destruction by human PMNs.
Compounds Derived from Garlic as Bud Induction Agents in Organic Farming of Table Grape (2008)

Viticulture is one of the most important economic activities in the Northwest of Mexico. A major obstacle for the economic production is the insufficient period of chilling temperatures. This problem leads to poor budbreak, which in turn results in reduced yields. This problem is aggravated when plants are cultivated using the organic farming system, mostly because there are not organically approved restbreaking agents. In this work different products derived from garlic (Allium sativum L.) were obtained and evaluated as stimulate budbreak agent of table grape (Vitis vinifera L.) cvs. Flame Seedless and Perlette. The isolated compounds were chemically identified and include allicin, diallyl disulfide, diallyl trisulfide, 3-vynil-[4H]-1.2-ditiin and 2-vynil-[3H]-1.3-ditiin, S-methyl cysteine sulphoxide, dimethyl disulfide, dimethyl trisulfide and dimethyl thiosulfonate. Cuttings with six buds were used to evaluate the compounds. After compounds were applied, the cuttings were transferred to a growing chamber at 24 C. All evaluated compounds promoted budbreak in the cuttings of Flame Seedless and Perlette. The volatile compounds from S-methyl cysteine sulfoxide promoted 100% of budbreak of both cultivars. The compounds from garlic that stimulated budbreak in grapevines in this work include sulphur in their molecule; therefore we propose that sulphur could play a key role in breaking bud dormancy of grape cultivars evaluated in this study.
Overview of Single-Stage Isolated AC-DC Topologies for Interfacing DC and AC Grids (2022)

The large-scale deployments of dc appliances and renewable generation have increased industry and research interest in dc electrical distribution systems for homes, offices, and other small buildings. In these systems, it is necessary to provide an isolated active front-end (AFE) interface between an ac grid and a residential dc microgrid/nanogrid. These power devices are often referred to as isolated active front-end (i-AFE) or grid interface converters. Single-stage isolated ac-dc converters can be a promising solution for the concept of the i-AFE converters. Single-stage topologies have no intermediate dc bus and potentially lead to reduced system weight, volume, and cost, compared to traditional two-stage solutions (ac-dc/dc-dc). Despite the potential advantages, single-stage isolated ac-dc converters are still an emerging topic in power electronics, which has not yet gained wide industrial adoption. This paper provides an overview of single-stage isolated ac-dc topologies, for dc microgrids application.
Reconstitution of Arabidopsis casein kinase II from recombinant subunits and phosphorylation of transcription factor GBF1. (1995)

In contrast to the well-defined tetrameric structure of animal and yeast casein kinase II (CKII), plant CKII is found in two forms: a monomeric form and an oligomeric form whose subunit composition is not well defined. The Arabidopsis homologs of the catalytic subunit alpha (CKA1) and the regulatory subunit beta (CKB1) of CKII were expressed in Escherichia coli to examine their ability to form complexes, the effect of CKB1 on the catalytic activity, and the relationship of the recombinant enzymes to those isolated from plant material. Both subunits were found mainly in the inclusion body fraction in the bacterial expression strains, and they were solubilized and renatured with the recovery of catalytic (CKA1) and stimulatory (CKB1) activities. The combination of purified CKA1 and CKB1 proteins resulted in up to 100-fold stimulation of casein kinase activity compared with the CKA1 activity alone, showing that CKB1 has biochemical properties similar to those of the beta subunit from animals. CKA1 and CKB1 spontaneously assembled into a tetrameric complex, CKA1(2)CKB12, which had properties very similar to those of the oligomeric CKII form isolated from broccoli. However, the properties of the catalytic subunit CKA1 alone differed from those of the broccoli monomeric form of CKII-like activity. Phosphorylation of transcription factor GBF1 with the reconstituted CKA1(2)CKB1(2) enzyme resulted in stimulation of its DNA binding activity and retardation of the protein-DNA complex; these results are identical to those obtained previously with isolated nuclear CKII from broccoli.
Elimination of ALDH+ breast tumor initiating cells by docosahexanoic acid and/or gamma tocotrienol through SHP-1 inhibition of Stat3 signaling (2015)

Study investigated the ability of docosahexaenoic acid (DHA) alone and in combination with gamma-tocotrienol (γT3) to eliminate aldehyde dehydrogenase positive (ALDH+) cells and to inhibit mammosphere formation, biomarker and functional assay for tumor initiating cells (TICs), respectively, in human triple negative breast cancer cells (TNBCs), and investigated possible mechanisms of action. DHA upregulated Src homology region 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) protein levels and suppressed levels of phosphorylated signal transducer and activator of transcription-3 (pStat3) and its downstream mediators c-Myc, and cyclin D1. siRNA to SHP-1 enhanced the percentage of ALDH+ cells and Stat-3 signaling, as well as inhibited, in part, the ability of DHA to reduce the percentage of ALDH+ cells and Stat-3 signaling. γT3 alone and in combination with DHA reduced ALDH+ TNBCs, up-regulated SHP-1 protein levels, and suppressed Stat-3 signaling. Taken together, data demonstrate the anti-TIC potential of achievable concentrations of DHA alone as well as in combination with γT3.
The Skin: Goal of the EU Polybioskin Project. (2017)

Cosmetic, personal care, sanitary and advanced medications have an increasing global market of about 50 billion dollars.All these products are in continuous contact with the skin and therefore, have to be produced with a high grade of safeness. Moreover they have to be possibly biodegradable and really effective.The EU PolyBioSkin research project aims to produce them by the use of biopolymers obtained from waste materials in order to reduce the petrol-based polymers also.This paper will report some data recovered by the first PolyBioSkin consortium kick off meeting organized by the SME project coordinator IRIS last July in Spain.
Phyllamyricins A-C, Three Novel Lignans from Phyllanthus myrtifolius (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhyllamyricins A-C, Three Novel Lignans from Phyllanthus myrtifoliusMei-Tsu Lin, Shoei-Sheng Lee, and Karin C. S. Chen LiuCite this: J. Nat. Prod. 1995, 58, 2, 244–249Publication Date (Print):February 1, 1995Publication History Published online1 July 2004Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/np50116a013https://doi.org/10.1021/np50116a013research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Surrogate parameter identification for coupled lithium-ion cell models (2015)

Purpose The need to optimize and simulate lithium-ion cells is of high importance to their durability. It is possible to use semi-empirical models based on equivalent circuits to model the dynamic behavior. Still, parameter identification is a time consuming task if many equivalent circuits are coupled into a finite element-based simulation. The paper aims to discuss these issues.
Development and validation of a short-term breast health measure as a supplement to screening mammography (2022)

The work presented here builds on previous studies focused on biomarker identification in tear samples. Here we show successful early classification of samples using two proteins and minimal clinical covariates.
Dynamic Simulation of an Electrostatically Actuated Impact Microactuator (2004)

We study the dynamics of an electrostatically driven impact microactuator reported by Mita and associates. The microactuator is modeled as a two-degree-of-freedom rigid multibody system. The impact phenomenon is described by a simple impact law based on Newton’s coefficient of restitution. The system dynamics is intensively studied. We investigate the influence of various parameters including excitation frequency and voltage.
Residual Stress Characteristics of Ceramic Coatings and Their Cracking Behavior (1989)

The residual stress of metal-to-ceramic laminates (stabilized ZrO2/Nb and Al2O3/Nb) produced by solid state bonding was studied using finite element method (FEM) analysis. The results indicated that the dimensionless residual stress at the ceramic coatings decreased with increasing coating thickness ratio, (hc/hs), and elastic modulus ratio, (1-μs)Ec/[(1-μc)Es]. Further, using the results of residual stress analysis and the bending strength of sintered stabilized ZrO2 and Al2O3 the critical temperature for coating to prevent cracking was estimated. The analytical results were in good agreement with the cracking behavior of HIP treated ceramic coatings, but in the case of Al2O3 coated specimens, the dependence of cracking on HIP temperature was not in agreement with the analytical results, because of the phase transformation of the Al2O3 coating.