gebhart/patrepeval huggingface dataset:
Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients (2016)

The activated partial thromboplastin time (APTT) assay is a basic hemostatic assay based on the time it takes for clots to form in plasma samples after the addition of calcium chloride. It is used to screen for various coagulation disorders. Several previous reports have suggested that magnesium (Mg) might contribute to coagulation reactions by binding to specific coagulation proteins. We investigated the effects of Mg on the APTT. In healthy controls, the APTT was significantly prolonged in proportion to the increase in the concentration of magnesium chloride in the range from 2.1 to 16.7 mmol/L. Among eight samples from patients with various disorders that exhibited prolonged APTT, two samples demonstrated shorter APTT when Mg was added, both of which were from patients that were positive for lupus anticoagulant. When we examined 206 clinical APTT samples, we found that Mg shortened the APTT of two samples. These two samples were also from lupus anticoagulant-positive patients (p-value: <0.003). Our findings regarding the unique effects of exogenous Mg on the APTT of lupus anticoagulant-positive patients might shed light on the role of Mg in APTT assays and lead to the development of a novel screening method for lupus anticoagulant.
<title>Overlay Performance Of The Perkin-Elmer Model 500</title> (1983)

We describe the procedures and results of overlay performance evaluation conducted on production Micralign Series Model 500s. Studies of machine-to-contact print and machine-to-machine overlay, stability, and automatic alignment are presented. Preliminary results on automatic alignment indicate that the 98% limit of total overlay error - alignment plus distortion - can be kept below 0.3 &mu;m.
On the melting point depression, coalescence, and chemical ordering of bimetallic nanoparticles: the miscible Ni–Pt system (2022)

Among the properties that distinguish nanoparticles (NPs) from their bulk counterparts is their lower melting points. It is also common knowledge that relatively low melting points enhance the coalescence of (usually) nascent nanoclusters toward larger NPs. Finally, it is well established that the chemical ordering of bi- (or multi-) metallic NPs can have a profound effect on their physical and chemical properties, dictating their potential applications. With these three considerations in mind, we investigated the coalescence mechanisms for Ni and Pt NPs of various configurations using classical molecular dynamics (MD) computer simulations. Benchmarking the coalescence process, we identified a steeper melting point depression for Pt than for Ni, which indicates a reversal in the order of melting for same-size NPs of the two elements. This reversal, also evident in the nano-phase diagram thermodynamically constructed using the regular solution model, may be useful for utilising NP coalescence as a means to design and engineer non-equilibrium NPs <i>via</i> gas-phase synthesis. Indeed, our MD simulations revealed different coalescence mechanisms at play depending on the conditions, leading to segregated chemical orderings such as quasi-Janus core-satellite, or core-(partial) shell NPs, despite the expected theoretical tendency for elemental mixing.
Insulin pens dribble from the tip of the needle after injection (2000)

Aim. To study different insulin pens regarding leakage from the tip of the needle after injection. Patients and method. Six pens were tested; Saline Pen 3.0 ml (Lilly), B-D Pen 3.0 ml, NovoLet 1.5 and 3.0 ml, NovoPen 1.5 and 3.0 ml. Twenty volunteers were injected with sterile saline and the needle was withdrawn after 1, 3, 5, or 7 s respectively. Any dribble was collected on a filter paper and weighed. The procedure was videotaped. Results. There was a minimum of dribbling from the 1.5 ml pens. Eight out of 20 NovoPen 3.0 ml and B-D Pen 3.0 ml, 16 out of 20 NovoLet 3.0 ml, and 19 out of 20 Saline Pen (Lilly) dribbled after a 7 s hold-in time. The 8 B-D Pen 3.0 ml had leaked 4.0 mg (2.4–18.8), the 8 NovoPen 3.0 ml 4.7 mg (3.8–6.7), the 16 NovoLet 3.0 ml 5.0 mg (3.1–16.6) and the 19 Saline Pen 3.0 ml had leaked 9.2 mg (4.9–19.1). Conclusion. There is a clinically significant leakage of fluid from the needle tip even after 7 s hold-in time. Patients should be taught to hold the needle in for at least 10 s to be assured they get the intended dose. Copyright © 2000 John Wiley & Sons, Ltd.
HPLC−Fluorescence Method for the Determination of Eprinomectin Marker Residue in Edible Bovine Tissue (1997)

A method was developed and validated to determine eprinomectin marker residue in bovine liver, kidney, muscle, and fat. The overall percent recovery (± CV) was 93 ± 12% (n = 66) for liver, 100 ± 13% (n = 34) for muscle, 87 ± 13% (n = 42) for kidney, and 95 ± 11% (n = 42) for fat. The limit of detection was 1 ng/g, the lower limit of quantitation was 2 ng/g, and the upper limit of quantitation was 5000 ng/g (μg/kg). Accuracy, precision, linearity, selectivity, and ruggedness were demonstrated. For the determination, tissue is mixed with sodium sulfate, homogenized, and extracted. The reconstituted extract is loaded onto an aminopropyl cartridge. After solvent exchange, a portion of the eluate is derivatized precolumn via automated addition of TFAA in acetonitrile and analyzed using fluorescence detection. The method is rapid, sensitive, and selective and provides for determination of eprinomectin marker residue in edible bovine tissue from the low parts per billion (ng/g) level to the parts per million level. The method has been successfully performed by several different analysts. Keywords: Avermectins; tissue residue; fluorescence; eprinomectin; HPLC; SPE
Laser interaction based on resonance saturation (LIBORS): an alternative to inverse bremsstrahlung for coupling laser energy into a plasma (1979)

Resonance saturation represents an efficient and rapid method of coupling laser energy into a gaseous medium. In the case of a plasma superelastic collision quenching of the laser maintained resonance state population effectively converts the laser beam energy into translational energy of the free electrons. Subsequently, ionization of the laser pumped species rapidly ensues as a result of both the elevated electron temperature and the effective reduction of the ionization energy for those atoms maintained in the resonance state by the laser radiation. This method of coupling laser energy into a plasma has several advantages over inverse bremsstrahlung and could therefore be applicable to several areas of current interest including plasma channel formation for transportation of electron and ion beams, x-ray laser development, laser fusion, negative ion beam production, and the conversion of laser energy to electricity.
An Experimental Study of Synthetic Fiber Reinforced Cementitious Composites (1987)

Peer Reviewed
Disseminated neuroblastoma in the nude rat: A xenograft model of human malignancy (1996)

BACKGROUND The overall survival of children with neuroblastoma remains less than 30% due to disease dissemination at the time of diagnosis. An animal model of neuroblastoma, with characteristics similar to those observed clinically in children, would be beneficial to investigations into the diverse biology of this tumor. The purpose of this study was (1) to develop a model of disseminated neuroblastoma in the nude rat by intracardiac injection of neuroblastoma cells derived from cell lines with different N-myc copy numbers; (2) to investigate the effect of age on tumor growth and dissemination; and (3) to assess progression of disease radiologically and correlate with autopsy findings. METHODS Nude rats (n = 38), 5–13 weeks of age, underwent intracardiac injection of the human neuroblastoma cell lines IMR-32 with amplified N-myc oncogene and SKNSH with 1 N-myc copy. The animals were observed for at least six weeks for the development of tumor. Twelve rodents injected with IMR-32 cells underwent imaging studies including magnetic resonance imaging (MRI), skeletal radiographs, and indium-111(IN-111)-diethylenetriamine penta-acetic acid-D-Phe1-octreotide scintigraphy. Autopsies with standardized microscopic examinations were performed on all animals. RESULTS Most of the nude rats (95%) developed neuroblastoma following intracardiac injection of neoplastic cells. Disseminated tumor was evident in 66% of animals. Anatomic sites of neuroblastoma growth were similar to those observed clinically in children, including adrenal glands, paraspinal ganglia, bone, bone marrow, and skin, but no tumor was identified in the liver. Disseminated disease occurred in more animals injected with IMR-32 (78% of animals) than with SKNSH cells (34% of animals) (P < 0.05). Tumor spread appeared to be age dependent; only rodents 5–8 weeks old at the time of injection developed disseminated disease when compared with animals 9 weeks of age or older (P < 0.0001). Radioreceptor scintigraphy demonstrated only pericardial tumor; MRI identified pericardial, adrenal gland, and subcutaneous neoplasms; only skeletal radiographs detected neuroblastoma in cortical bone. CONCLUSIONS (1) Following intracardiac injection of human neuroblastoma cell lines into nude rats, a xenograft model of disseminated disease develops that closely parallels the malignant process in children. (2) Tumor dissemination is associated with the cell line that demonstrates N-myc amplification and with young age of the recipient at the time of injection. (3) Tumor growth and dissemination may be assessed radiologically. (4) This model of human malignancy may offer an opportunity to investigate the pathophysiologic mechanisms underlying tumor development and dissemination in advanced stage neuroblastoma. Cancer 1996;77:409-19.
Fabrication and Microstructure of Silicon Nitride/Boron Nitride Nanocomposites (2002)

A chemical process for fabrication of Si 3 N 4 /BN nanocomposite was devised to improve the mechanical properties. Si 3 N 4 /BN nanocomposites containing 0 to 30 vol% hexagonal BN ( h ‐BN) were successfully fabricated by hot‐pressing α‐Si 3 N 4 powders, on which turbostratic BN ( t ‐BN) with a disordered layer structure was partly coated. The t ‐BN coating on α‐Si 3 N 4 particles was prepared by reducing and heating α‐Si 3 N 4 particles covered with a mixture of boric acid and urea. TEM observations of this nanocomposite revealed that the nanosized hexagonal BN ( h ‐BN) particles were homogeneously dispersed within Si 3 N 4 grains as well as at grain boundaries. As expected from the rules of composites, Young's modulus of both micro‐ and nanocomposites decreased with an increase in h ‐BN content, while the fracture strength of the nanocomposites prepared in this work was significantly improved, compared with the conventional microcomposites.
Free vibration analysis of a rotating double tapered beam with flexible root via differential quadrature method (2021)

Purpose This study aims to develop the governing differential equation and to analyze the free vibration of a rotating non-uniform beam having a flexible root and setting angle for variations in operating conditions and structural design parameters. Design/methodology/approach Hamiltonian principle is used to derive the flapwise bending motion of the structure, and the governing differential equations are solved numerically by using differential quadrature with satisfactory accuracy and computation time. Findings The results obtained by using the differential quadrature method (DQM) are compared to results of previous studies in the open literature to show the power of the used method. Important results affecting the dynamics characteristics of a rotating beam are tabulated and illustrated in concerned figures to show the effect of investigated design parameters and operating conditions. Originality/value The principal novelty of this paper arises from the application of the DQM to a rotating non-uniform beam with flexible root and deriving new governing differential equation including various parameters such as rotary inertia, setting angle, taper ratios, root flexibility, hub radius and rotational speed. Also, the application of the used numerical method is expressed clearly step by step with the algorithm scheme.
[Prevention of microaggregation in stored blood (author's transl)]. (1976)

Microembolism is still a feared complication during and after blood transfusions. Up to now they could only be diminished by special filter systems. In spite of much research it has not been possible as yet to fine adequate remedies for the preservation of blood cells and for the decrease of aggregation in stored blood. As foregoing studies have shown the inhibition of aggregation is combined with a considerable impairment or even loss of platelet function. In these clinical experiments, however, it has been shown, that aggregations in stored blood are significantly stunted by early addition of Aprotinin. It is clinically important, that no inhibition of platelet function occured.
Physical Properties of Whey Protein Stabilized Emulsions as Related to pH and NaCl (1997)

ABSTRACT Corn oil‐in‐water emulsions (20 wt%, d 32 ∼ 0.6 μm) stabilized by 2 wt% whey protein isolate were prepared with a range of pH (3–7) and salt concentrations (0–100 mM NaCl), and particle size, rheology and creaming were measured at 30°C. Appreciable droplet flocculation occurred near the isoelectric point of whey protein (pH 4–6), especially at higher NaCl concentrations. Droplet flocculation increased emulsion viscosity and decreased stability to creaming. Results are related to the influence of environmental conditions on electrostatic and other interactions between droplets.
27/#729 First clinical study reporting adoption of ERAS in CRS HIPEC as per published guidelines: time to adopt, evolve & improve (2022)

<h3>Objectives</h3> We report our experience of implementation of ERAS protocol in CRS and HIPEC for peritoneal carcinomatosis as per guidelines published in december 2020. <h3>Methods</h3> ERAS protocol for CRS± HIPEC was implemented in 80 patients from January 2021 to March 2022. We documented compliance rate and analysed the reason for non-compliance, effect of compliance on length of hospital stay, postoperative complications and readmission rate and compared the same with the 95 patients who had CRS HIPEC before adopting ERAS protocol from January 2019 to December 2020 <h3>Results</h3> Of 175 patients in the study, 95 were in pre eras group and 80 in ERAS group. Demography, pre-operative and operative parameters were comparable between the groups. The average compliance rate achieved for entire cohort was 78.5%. Lowest compliance rates were seen for post-operative elements especially, early feeding and early mobilization. After implementation of ERAS, median length of hospital stay reduced from 12 to 9 days, length of ICU stay reduced from 4 to 2 days and postoperative complications sepsis reduced from 14.7% to 7%, respiratory complications 15.7% to 7%, surgical complications 10.5% to 2.9%, resurgery from 6.3% to 1.4% and in hospital mortality reduced from 5.3% to 1.4%. The ERAS group didn’t receive any long acting opioids, less usage of intraoperative crystalloids(7 ml/kg/hr vs 13 ml/kg/hr, p = 0.0001),early extubation and less readmission rates. <h3>Conclusions</h3> The implementation of ERAS protocol is safe and feasible for CRS and HIPEC patients. Implementation of ERAS program has significantly reduced the length of hospital stay, length of ICU stay and postoperative morbidity.
Enhance horizontal well performance by optimising multistage hydraulic fracture and water flooding (2017)

In naturally fractured tight oil reservoirs, the combination of multistage fractured horizontal well and water flooding could enhance production rate and ultimate recovery. This paper introduces the combination of composite double porosity model and local refinement Technology to optimise the performance of multistage fractured horizontal well. In base of the non-uniform distributions of natural fractures, we adopt different shape factors of dual-porosity model to distinguish the stimulated area and unstimulated zone. By comparing with the performance of different SRV shapes, the optimal design of SRV is irregular shape with scattered distribution of fracture length at different locations of wellbore. The optimal size of SRV, cluster spacing, width of SRV are presented. In addition, in seven-spot injection/production well pattern, this paper presents the optimisation of multistage fractured horizontal well orientation with different SRV shapes (single-spindle and double-spindle), and well spacing. [Received: May 18, 2015; Accepted: March 1, 2016]
Current and novel therapeutic strategies in celiac disease (2016)

We conducted a search of PubMed and clinicaltrials.gov to extract articles on CD using keywords including 'celiac disease' and 'refractory celiac disease' (RCD) and focused on articles conducting pathophysiologic and therapeutic research in/ex-vivo models and human trials. We highlight novel therapeutics that manipulate these mechanisms including tight junction regulators, glutenases, gluten sequestrants and immunotherapy using vaccines, nanoparticles that may serve as adjuncts to a GFD or more ambitiously to allow for gluten consumption. We also highlight the role of anti-inflammatories, immunosuppressants and monoclonal antibodies in RCD. Expert commentary: Therapeutics including tight junction regulators, glutenases have the potential to be approved for non-responsive CD or as gluten adjuncts. We expect results of various phase 1/2 trials using AMG 714, BL 7010, IgY antibodies to be published. In the interim, off-label use of 5 amino-salicylates, budesonide, nucleoside analogues and newer biologics developed for other inflammatory diseases will be used in RCD.
CHARACTERISTICS OF CONTROLLED VS. RESISTANT ESSENTIAL HYPERTENSIVE PATIENTS AFTER A STANDARDIZED 4-WEEK THREE DRUG-REGIMEN (2011)

Bobrie, G.; Frank, M.; Azizi, M.; Peyrard, S.; Boutouyrie, P.; Chatellier, G.; Laurent, S.; Menard, J.; Plouin, P-F. Author Information
Supp Table 1 from Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression (2023)

&lt;p&gt;Target Genes with greater than 90% inhibition at 100nM&lt;/p&gt;
The chemistry of nitro-compounds. Part I. Acid-catalysed ring-opening reactions of substituted o-nitrophenylethylene oxides involving participation by the nitro-group (1971)

Ethereal hydrogen chloride converts trans-1-acetyl- and 1-benzoyl-2-(o-nitrophenyl)ethylene oxides (1c and a) in low yield into the corresponding 6-chloro-1,3-dihydroxyquinolin-4-ones (2a and c). In contrast, reaction of the cis-benzoyl epoxide (1b) or of the 1,1-diacylethylene oxides (1d and e) with ethereal hydrogen chloride affords high yields of the compounds (2a and c). In the presence of hydroquinone these reactions give the chlorine-free 1,3-dihydroxyquinolones (2b and d). The course and mechanism of the reactions are discussed.Manganese dioxide oxidation of the 1-hydroxyquinolones (2a—d) and of the reduction products (3a and b) affords the hitherto unknown quinoline-3,4-quinones (7a—d) and (8a and b).
Facile Preparation of a Thiol-Reactive 18F-Labeling Agent and Synthesis of 18F-DEG-VS-NT for PET Imaging of a Neurotensin Receptor–Positive Tumor (2014)

We have established a facile (18)F-labeling method for site-specific labeling of the Cys-NT. Using this method, we synthesized an NTR-targeted PET agent, which demonstrated high tumor-to-background contrast.
Effect of Ga Pre-Deposition Rate on GaAs Nanowires Grown by Self-Assisted VLS Method Using MBE on SiO<sub>2</sub>/Si(111) Substrates (2015)

We report on the study on effect of Ga pre-deposition rate on GaAs nanowires grown by self-assisted vapor-liquid-solid (VLS) method. Ga droplets were initially deposited on the surface of Si(111) substrates covered with thin layer of SiO 2 . The nanowires were grown by molecular beam epitaxy (MBE). Dependency of structural of nanowires on Ga pre-deposition rate is investigated by Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), and X-ray Diffraction Analysis (XRD). The experimental results show that the different in Ga pre-deposition rate significantly affect the surface morphology of samples. Growth rate and the density of nanowires strongly depends on the Ga pre-deposition rate.
Draft genome of the reindeer ( Rangifer tarandus ) (2017)

Our results provide the first high-quality reference genome for the reindeer and a valuable resource for studying the evolution, domestication, and other unusual characteristics of the reindeer.
Helping online customers decide through Web personalization (2002)

The Web-based personalization system proposed here uses both collaborative filtering and Web usage mining to give online shoppers the personalized recommendations they need to purchase products more intelligently.
Incidence of Anterior Cruciate Ligament Injury among Active Duty U.S. Military Servicemen and Servicewomen (2007)

Although some studies have reported an increased incidence of anterior cruciate ligament (ACL) injuries in women athletes, little is known about the gender differences in injury patterns in the U.S. military. Using the Defense Medical Epidemiology Database, a search was performed for International Classification of Diseases, 9th Revision (ICD-9) codes 717.83 (old disruption of ACL) and 844.2 (sprain, strain cruciate ligament of the knee) among all servicemen and servicewomen between 1997 and 2003. Multivariate Poisson regression analysis was used to estimate the rate of ACL injuries per 1000 person-years, controlling for age and race, for each ICD-9 code. We computed rate ratios and 95% confidence intervals (CIs) by using male as the reference category. The injury rates for code 717.83 were 3.09 cases per 1,000 person-years for men and 2.29 cases per 1000 person-years for women, controlling for age and race (relative risk, 0.74; 95% CI, 0.71-0.76). The injury rates for ICD-9 code 844.2 were 3.79 cases per 1000 person-years for men and 2.95 cases per 1,000 person-years for women, controlling for age and race (relative risk, 0.78; 95% CI, 0.76-0.80). There was not an observed increase in the incidence of ACL injuries among female soldiers in the U.S. military between 1997 and 2003.
α′-Hydroxyenones as Mechanistic Probes and Scope-Expanding Surrogates for α,β-Unsaturated Aldehydes in N-Heterocyclic Carbene-Catalyzed Reactions (2009)

N-heterocyclic carbene-catalyzed reactions of alpha,beta-unsaturated aldehydes and a variety of electrophiles allow the facile preparation of a diverse array of annulation products including trisubstituted cyclopentenes, gamma-lactams, and bicyclic beta-lactams. The substrate scope of these reactions, however, is limited by the difficulties of preparing the starting alpha,beta-unsaturated aldehydes. We now report that alpha'-hydroxyenones, which can be prepared in a single convenient step from aromatic and heteroaromatic aldehydes, can serve as efficient surrogates for enals in the annulation reactions. This protocol allows the facile preparation and use of substrates bearing nitrogen heterocycles. These reagents have also allowed us to demonstrate that, in contrast to other classes of aldehydes, the formation of the Breslow intermediate from enals and N-heterocyclic carbenes is irreversible under the reaction conditions.