gebhart/patrepeval huggingface dataset:
CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface (2015)

Members of the transforming growth factor β (TGFβ) family initiate cellular responses by binding to TGFβ receptor type II (TβRII) and type I (TβRI) serine/threonine kinases, whereby Smad2 and Smad3 are phosphorylated and activated, promoting their association with Smad4. We report here that TβRI interacts with the SH3 domains of the adaptor protein CIN85 in response to TGFβ stimulation in a TRAF6-dependent manner. Small interfering RNA-mediated knockdown of CIN85 resulted in accumulation of TβRI in intracellular compartments and diminished TGFβ-stimulated Smad2 phosphorylation. Overexpression of CIN85 instead increased the amount of TβRI at the cell surface. This effect was inhibited by a dominant-negative mutant of Rab11, suggesting that CIN85 promoted recycling of TGFβ receptors. CIN85 enhanced TGFβ-stimulated Smad2 phosphorylation, transcriptional responses, and cell migration. CIN85 expression correlated with the degree of malignancy of prostate cancers. Collectively, our results reveal that CIN85 promotes recycling of TGFβ receptors and thereby positively regulates TGFβ signaling.
Abstract LB-205: Myeloid cells are required to establish an immune-suppressive regulatory network in pancreatic cancer by activating the PD-1/PD-L1 checkpoint (2015)

Abstract Background: Pancreatic cancer is characterized by the accumulation of a fibro-inflammatory stroma. Myeloid cells are a predominant population within the stroma. Different myeloid cell subsets have been correlated with tumor promotion and unmasking of anti-tumor immunity. Objective: The goal of this study was to determine the effect of myeloid cell depletion on the onset and progression of pancreatic cancer, and to understand the relationship between myeloid cells and T cell infiltration and activity within the pancreatic cancer microenvironment. Methods: Primary mouse pancreatic cancer cells were transplanted in CD11b-DTR mice. CD11b+ cells (most myeloid cell populations) were depleted by Diphtheria Toxin treatment; either at the time of tumor implantation or after tumors had formed. Results Depletion of myeloid cells delayed tumor initiation. In pre-established tumors, myeloid cell depletion resulted in arrest of growth or tumor regression. We observed that tumor regression was dependent myeloid cell-mediated blockade of CD8+ T cell anti-tumor activity. We investigated the mechanism of this inhibition. We found that myeloid cells regulate expression of the immune checkpoint ligand Programmed death-ligand 1 (PD-L1) in the tumor cells in an EGFR/MAPK dependent manner. Conclusions: Our results show that myeloid cells regulate a complex network of signals that ensure immune suppression within the pancreatic cancer microenvironment. Moreover, we show that depletion of the myeloid cell population is sufficient to restore anti-tumor immunity mediated by CD8+ T cells, a finding with implications for the design of immune therapies for pancreatic cancer. Citation Format: YAQING ZHANG, ESHA MATHEW, FLOR MENDEZ, KEVIN FLANNAGAN, DIANE SIMEONE, MARINA PASCA DI MAGLIANO. Myeloid cells are required to establish an immune-suppressive regulatory network in pancreatic cancer by activating the PD-1/PD-L1 checkpoint. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-205. doi:10.1158/1538-7445.AM2015-LB-205
Mechanical and histomorphometric evaluations of rough titanium implants treated with hydrofluoric acid/nitric acid solution in rabbit tibia. (2011)

The treatment with HF/HNO3 solution promotes bone formation and osseointegration after 4 and 8 weeks of bone healing in the rabbit tibia model.
Sedimentology and fluvial styles of the uppermost Cretaceous continental deposits of the Austral-Magallanes Basin, Patagonia, Argentina (2018)

The sedimentary infill of the Austral-Magallanes Basin since the onset of its foreland stage in the Lago Argentino region is dominated by deep-marine and coastal deposits. However, during the Late Cretaceous the basin accumulated a thick and poorly known continental sedimentary succession, which has received different lithostratigraphic names. The aim of this work is to characterize the here defined Uppermost Cretaceous Continental Deposits (UCCD) from a detailed facies and architectural analysis, as well as the resulting stacking pattern. Seven Facies Associations (FAs) were discriminated in order to define the sedimentary paleoenvironments: FA1, gravelly sheet bodies; FA2, tabular bodies of conglomerates with mud rip-up clasts; FA3, complex tabular sandy bodies; FA4, simple tabular sandy bodies; FA5, tabular bodies of structureless sandstones; FA6, heterolithic deposits; and FA7, fine-grained deposits. Three different fluvial styles were recognized: meandering systems dominated by avulsion and meander abandonment processes (fluvial style a), braided systems (fluvial style b), and meandering systems dominated by overbank flood processes (fluvial style c). The stacking pattern of the FAs allowed to divide the UCCD into two major depositional stages related to the accommodation space vs sediment supply (A/S) ratio. Stage I is characterized by the alternation of fluvial styles a and b, while the Stage II is represented by the alternation of fluvial styles c and b, and the Stage III is characterized entirely by fluvial style c deposits. Although the UCCD are considered as a whole within a framework of low A/S ratio, several high frequency variations were recognized. The Stage I records seven high frequency intervals of which four are characterized by high A/S ratio interrupted by three events of low A/S. While the stage II is represented by six high frequency periods of low A/S ratio and other five high frequency events of high A/S ratio. The Stage II is considered as deposited in a relative higher A/S context in comparison with the Stage I, based on the behavior of the moderate to high sinuosity meander fluvial systems. Finally, the Stage III is represented entirely by a high frequency low A/S ratio event.
Enzyme Properties of a Laccase Obtained from the Transcriptome of the Marine-Derived Fungus Stemphylium lucomagnoense (2020)

Only a few studies have examined how marine-derived fungi and their enzymes adapt to salinity and plant biomass degradation. This work concerns the production and characterisation of an oxidative enzyme identified from the transcriptome of marine-derived fungus <i>Stemphylium lucomagnoense</i>. The laccase-encoding gene <i>Sl</i>Lac2 from <i>S. lucomagnoense</i> was cloned for heterologous expression in <i>Aspergillus niger</i> D15#26 for protein production in the extracellular medium of around 30 mg L<sup>-1</sup>. The extracellular recombinant enzyme <i>Sl</i>Lac2 was successfully produced and purified in three steps protocol: ultrafiltration, anion-exchange chromatography, and size exclusion chromatography, with a final recovery yield of 24%. <i>Sl</i>Lac2 was characterised by physicochemical properties, kinetic parameters, and ability to oxidise diverse phenolic substrates. We also studied its activity in the presence and absence of sea salt. The molecular mass of <i>Sl</i>Lac2 was about 75 kDa, consistent with that of most ascomycete fungal laccases. With syringaldazine as substrate, <i>Sl</i>Lac2 showed an optimal activity at pH 6 and retained nearly 100% of its activity when incubated at 50°C for 180 min. <i>Sl</i>Lac2 exhibited more than 50% of its activity with 5% wt/vol of sea salt.
Isolation and Synthesis of New Antioxidants from Sunflower Seeds (1997)

Abstract By the guide of inhibition assay towards photooxidation of β-carotene, two active arylindane type phenolic compounds were isolated from sunflower seeds. The structures were determined by extensive spectroscopic analyses, and finally were confirmed by comparison of their spectral data with those of authentic samples prepared by dimerization of methyl 3,4-dihydroxycinnamate with trifluoroacetic acid.
Quantification of high and low sEMG spectral components during sustained isometric contraction (2022)

Superficial Electromyography (sEMG) spectrum contains aggregated information from several underlying physiological processes. Due to technological limitations, the isolation of these processes is challenging, and therefore, the interpretation of changes in muscle activity frequency is still controversial. Recent studies showed that the spectrum of sEMG signals recorded from isotonic and short-term isometric contractions can be decomposed into independent components whose spectral features recall those of motor unit action potentials. In this paper sEMG spectral decomposition is tested during muscle fatigue induced by long-term isometric contraction where sEMG spectral changes have been widely studied. The main goals of this work are to validate spectral component extraction during long-term isometric muscle activation and the quantification of energy exchange between the low- and high-frequency bands of sEMG signals during muscle fatigue.
Surface-bound metal hydrocarbyls. Organometallic connections between heterogeneous and homogeneous catalysis (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-bound metal hydrocarbyls. Organometallic connections between heterogeneous and homogeneous catalysisTobin J. MarksCite this: Acc. Chem. Res. 1992, 25, 2, 57–65Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://doi.org/10.1021/ar00014a001RIGHTS & PERMISSIONSArticle Views1281Altmetric-Citations433LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Tracking and learning graphs and pose on image sequences of faces (2002)

We demonstrate a system capable of tracking in real world image sequences, landmarks such as eyes, mouth, or chin on a face. In the standard version, knowledge previously collected about faces is used for finding the landmarks in the first frame. In a second version, the system is able to track the face without any prior knowledge about faces and is thus applicable to other object classes. By using Gabor filters as visual features, and by both avoiding limiting assumptions and many parameters our tracking tool is simple and easy to use. As a first application the tracking results are used to estimate the pose of a face.
DEC-NoC: An Approximate Framework Based on Dynamic Error Control with Applications to Energy-Efficient NoCs (2018)

Network-on-Chips (NoCs) have emerged as the standard on-chip communication fabrics for multi/many core systems and system on chips. However, as the number of cores on chip increases, so does power consumption. Recent studies have shown that NoC power consumption can reach up to 40% of the overall chip power [1]-[3]. Considerable research efforts have been deployed to significantly reduce NoC power consumption. In this paper, we build on approximate computing techniques and propose an approximate communication methodology called DEC-NoC for reducing NoC power consumption. The proposed DEC-NoC leverages applications' error tolerance and dynamically reduces the amount of error checking and correction in packet transmission, which results in a significant reduction in the number of retransmitted packets. The reduction in packet retransmission results in reduced power consumption. Our cycle accurate simulation using PARSEC benchmark suites shows that DEC-NoC achieves up to 56% latency reduction and up to 58% dynamic power reduction compared to NoC architectures with conventional error control techniques.
Introduction to “The Woodward‐Hoffmann Rules. From May 5, 1964, to November 30, 1964”** (2023)

An introduction is provided to Publication 11 in the series of articles by the author on the history of the Woodward-Hoffmann (W-H) rules. Now permanently open access (CC-BY) at http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01792, Paper 11 was published in 2015 in The Journal of Organic Chemistry to celebrate the 50th anniversary of the W-H rules. This paper summarizes the content of Publications 1-10 in the series and provides an idea of the major components of Publication 11.
Pine processionary caterpillar as a new cause of immunologic contact urticaria (2000)

Nowadays, caterpillars are included among the agents that elicit contact urticaria by a non-immunologic mechanism. Our objective was to find the rôle that an IgE-mediated mechanism could have among patients with suspected contact urticaria from pine processionary caterpillars. 16 patients with suspected contact urticaria from this caterpillar were studied by prick testing and specific IgE detection by immunoblotting. 87% of the patients had a positive prick test and immunoblotting for caterpillar extract. In these allergic patients, the symptoms associated with urticaria were: angioedema (79%), conjunctivitis (36%) and severe anaphylaxis (14%). The most frequent localizations of the wheals were the neck (100%) and forearms (93%). Angioedema was more frequent on the eyelids (79%). The IgE-immunoblot detected in the caterpillar extract several reactive bands, with apparent MWs from to 45 to 4kDa. A total of 5 major allergens were identified, but a band around 14kDa proved to be the dominant allergen. Sensitization to Thaumetopoea pityocampa was found to be the most important mechanism of airborne contact urticaria from this caterpillar. Low-MW proteins are the main IgE binding components of crude caterpillar extract.
Device-to-Device Load Balancing for Cellular Networks (2015)

Small-cell architecture is widely adopted by cellular network operators to increase network capacity. By reducing the size of cells, operators can pack more (low-power) base stations in an area to better serve the growing demands, without causing extra interference. However, this approach suffers from low spectrum temporal efficiency. When a cell becomes smaller and covers fewer users, its total traffic fluctuates significantly due to insufficient traffic aggregation and exhibiting a large "peak to-mean" ratio. As operators customarily provision spectrum for peak traffic, large traffic temporal fluctuation inevitably leads to low spectrum temporal efficiency. In this work, we first carryout a case-study based on real-world 3G data traffic traces and confirm that 90% of the cells in a metropolitan district are less than 40% utilized. Our study also reveals that peak traffic of adjacent cells are highly asynchronous. Motivated by these observations, we advocate device-to-device (D2D) load-balancing as a useful mechanism to address the fundamental drawback of small-cell architecture. The idea is to shift traffic from a congested cell to its adjacent under-utilized cells by leveraging inter-cell D2D communication, so that the traffic can be served without using extra spectrum, effectively improving the spectrum temporal efficiency. We provide theoretical modeling and analysis to characterize the benefit of D2D load balancing, in terms of sum peak traffic reduction of individual cells. We also derive the corresponding cost, in terms of incurred D2D traffic overhead. We carry out empirical evaluations based on real-world 3G data traces to gauge the benefit and cost of D2D load balancing under practical settings. The results show that D2D load balancing can reduce the sum peak traffic of individual cells by 35% as compared to the standard scenario without D2D load balancing, at the expense of 45% D2D traffic overhead.
Merits of Using Color and Shape Differentiation to Improve the Speed and Accuracy of Drug Strength Identification on Over-the-Counter Medicines by Laypeople (2010)

Using color to differentiate drug strength information improves drug strength identification performance. Color differentiation of drug strength information may be a useful way of reducing medication errors and improving patient safety.
Convenient synthesis of the Chevrel phases metal molybdenum sulfide, MxMo6S8 (M = copper, lead, lanthanum or gadolinium) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient synthesis of the Chevrel phases metal molybdenum sulfide, MxMo6S8 (M = copper, lead, lanthanum or gadolinium)K. S. Nanjundaswamy, N. Y. Vasanthacharya, J. Gopalakrishnan, and C. N. R. RaoCite this: Inorg. Chem. 1987, 26, 25, 4286–4288Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ic00272a028https://doi.org/10.1021/ic00272a028research-articleACS PublicationsRequest reuse permissionsArticle Views766Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Noninflammatory Expression of E-Selectin Is Regulated by Cell Growth (1999)

E-selectin, an endothelial-specific adhesion molecule best known for its role in leukocyte adhesion, is not detected in quiescent endothelial cells, but is induced by inflammatory stimuli. However, E-selectin is also expressed in proliferating endothelial cells under noninflammatory conditions in vivo and in vitro, suggesting that E-selectin is also regulated by growth signals. To investigate E-selectin expression in lipopolysaccharide-stimulated versus nonstimulated proliferating cells, we analyzed the distribution of E-selectin–positive human microvascular endothelial cells in G0/G1, S, and G2/M phases of the cell cycle under both conditions. Lipopolysaccharide treatment resulted in uniformly increased E-selectin expression in cells in G0/G1, S, and G2/M. In contrast, levels of E-selectin in nonstimulated proliferating cells showed a linear correlation with the percentage of cells in G2/M. E-selectin in proliferating endothelial cells was not reduced by addition of soluble tumor necrosis factor-–receptor or soluble interleukin-1–receptor indicating that its expression was not due to endogenous production of either cytokine. In addition, E-selectin was increased in cells stimulated with basic fibroblast growth factor, a well-known mitogen for endothelial cells. E-selectin in proliferating endothelial cells is functional, as shown by E-selectin–dependent adhesion of the promyelocytic leukemia cell line HL-60 to subconfluent human microvascular endothelial cells. In summary, these studies indicate that E-selectin can be regulated by a non-inflammatory pathway that is related to the proliferative state of the endothelium.
Uremic Encephalopathy: MR Imaging Findings and Clinical Correlation (2016)

The lentiform fork sign is reliable in the early diagnosis of uremic encephalopathy, regardless of the presence of metabolic acidosis. Cytotoxic edema and/or vasogenic edema on DWI/ADC maps may be associated with uremic encephalopathy.
An Electro-Optically Tunable Bragg Reflector Based on Liquid Crystals (2011)

In this paper we report the analysis of a distributed feedback guided-wave reflector in liquid crystals and we describe the main properties of the device. The device is based on a comb-shaped interdigitated electrodes and a liquid crystal slab. The device shows a wide tuning range exceeding 100 nm covering C and L bands for wavelength division multiplexing.
A Quantitative and Qualitative Review of Neurocognitive Performance in Pediatric Bipolar Disorder (2020)

Bipolar disorder (BD) is an increasingly prevalent diagnosis in youth. As a result, there has been a corresponding increase in interest about neuropsychological and cognitive profiles in children and adolescents diagnosed with BD. Meta-analysis of the existing literature comparing individuals with BD to healthy controls indicated that the largest differences are observed for measures of verbal memory (d = 0.77). Moderate differences were found in the areas of attention (d = 0.62), executive functioning (d = 0.62), working memory (d = 0.60), visual memory (d = 0.51), visual perceptual skills (d = 0.48), and verbal fluency (d = 0.45). Small differences were found for measures of reading (d = 0.40), motor speed (d = 0.33), and full-scale intelligence quotient (IQ) (d = 0.32). Often, few studies have provided relevant information for a particular neurocognitive domain. Despite this, several domains displayed heterogeneity of effect sizes across studies. Methodological factors explained the variance in effect sizes to different extents depending upon the cognitive domain. The changing influence of method artifacts is likely due to variable coverage of cognitive domains across studies and the use of different measures across studies. Findings are consistent with previous meta-analyses of the adult BD neurocognitive literature, suggesting that many of the deficits observed in adults are present earlier in the course of the illness. Study reporting guidelines are offered that may help clarify the impact of illness definitions, mood state, medication status, and other methodological variables on neurocognition in pediatric BD.
[Hepatic puncture biopsy by the transjugular route]. (1976)

The authors report their experience of transjugular liver biopsy, a method which consists in taking a liver specimen with a needle placed in a hepatic vein. This method was used in 13 patients in whom conventional liver needle biopsy was contraindicated because of massive ascites or bleeding tendency. In 10 of these patients, a liver specimen was obtained; in patients with cirrhosis or chronic active hepatitis, the liver specimens were more or less divided into small fragments, which prevented correct assessment of liver architecture in three of them. The examination was well tolerated. The authors conclude that transjugular liver biopsy is not technically difficult in centers where hepatic vein catheterization is available and that this method is indicated in patients in whom conventional liver needle biopsy is contraindicated.