gebhart/patrepeval huggingface dataset:
The role of periplasmic antioxidant enzymes (superoxide dismutase and thiol peroxidase) of the Shiga toxin‐producing Escherichia coli O157:H7 in the formation of biofilms (2006)

This study examined the role of the periplasmic oxidative defense proteins, copper, zinc superoxide dismutase (SodC), and thiol peroxidase (Tpx), from the Shiga toxin-producing Escherichia coli O157:H7 (STEC) in the formation of biofilms. Proteomic analyses have shown significantly higher expression levels of both periplasmic antioxidant systems (SodC and Tpx) in STEC cells grown under biofilm conditions than under planktonic conditions. An analysis of their growth phase-dependent gene expression indicated that a high level of the sodC expression occurred during the stationary phase and that the expression of the tpx gene was strongly induced only during the exponential growth phase. Exogenous hydrogen peroxide reduced the aerobic growth of the STEC sodC and tpx mutants by more than that of their parental strain. The two mutants also displayed significant reductions in their attachment to both biotic (HT-29 epithelial cell) and abiotic surfaces (polystyrene and polyvinyl chloride microplates) during static aerobic growth. However, the growth rates of both wild-type and mutants were similar under aerobic growth conditions. The formation of an STEC biofilm was only observed with the wild-type STEC cells in glass capillary tubes under continuous flow-culture conditions compared with the STEC sodC and tpx mutants. To the best of our knowledge, this is the first mutational study to show the contribution of sodC and tpx gene products to the formation of an E. coli O157:H7 biofilm. These results also suggest that these biofilms are physiologically heterogeneous and that oxidative stress defenses in both the exponential and stationary growth stages play important roles in the formation of STEC biofilms.
Silencing Toll-like Receptor-9 inPseudomonas aeruginosaKeratitis (2005)

Signaling through TLR9 appears important in P. aeruginosa keratitis, and silencing TLR9 signaling reduces inflammation but likely contributes to decreased bacterial killing in the cornea.
JavaScript Template Attacks: Automatically Inferring Host Information for Targeted Exploits (2019)

Today, more and more web browsers and extensions provide anonymity features to hide user details. Primarily used to evade tracking by websites and advertisements, these features are also used by criminals to prevent identification. Thus, not only tracking companies but also law-enforcement agencies have an interest in finding flaws which break these anonymity features. For instance, for targeted exploitation using zero days, it is essential to have as much information about the target as possible. A failed exploitation attempt, e.g., due to a wrongly guessed operating system, can burn the zero-day, effectively costing the attacker money. Also for side-channel attacks, it is of the utmost importance to know certain aspects of the victim's hardware configuration, e.g., the instruction-set architecture. Moreover, knowledge about specific environmental properties, such as the operating system, allows crafting more plausible dialogues for phishing attacks.
Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives (1992)

A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives was synthesized and demonstrated to be orally active antiallergic agents. These compounds are structurally related to 1 (KW-4994), which we had reported previously to be a new antiallergic agent. Most compounds synthesized exhibited potent inhibitory effects on 48-h homologous passive cutaneous anaphylaxis (PCA) in rats and on IgG1-mediated bronchoconstriction in guinea pigs. Additionally, compounds possessing a terminal carboxyl group at the 2-position of the dibenz[b,e]oxepin ring system exhibited inhibitory effects on specific [3H]pyrilamine binding to guinea pig cerebellum histamine H1 receptors, whereas these demonstrated negligible effects on specific [3H]QNB binding to rat striatum muscarinic acetylcholine M1 receptors. Structure-activity relationship studies revealed that the following key elements were required for enhanced antiallergic activities: (1) a 3-(dimethylamino)propylidene group as the side chain at the 11-position, (2) a terminal carboxyl moiety at the 2-position, and (3) a dibenzoxepin ring system. Among the compounds synthesized, (Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz [b,e]oxepin-2-acetic acid hydrochloride (16) was selected for further evaluation. It had an ED50 value of 0.049 mg/kg po in the PCA test in rats and an ID50 value of 0.030 mg/kg po in inhibiting anaphylactic bronchoconstriction in guinea pigs. Furthermore, it had a Ki value of 16 +/- 0.35 nM for the histamine H1 receptor, while it exhibited negligible CNS side effects up to a dose of 600 mg/kg po. Compound 16 is now under clinical evaluation as KW-4679.
Methods for Determination of Condensed and Hydrolyzable Tannins (1997)

Tannins are natural products which are characterized by their phenolic nature and their ability to precipitate protein. Their diverse biological effects, and their common occurrence in plants used to make foods, beverages, herbal medicines, and animal feeds, have created widespread interest in methods for the analysis of tannins. However, their chemical complexity and diversity impose constraints upon the application of many of the analytical methods that have been developed. After briefly reviewing the chemistry of tannins, we describe some of the methods available for analysis of tannins, and outline the limitations of those methods. The discussion of each method emphasizes the utility of the method for analysis of mixtures of tannin, like those found in many foods. A procedure for preparative scale purification of a standard gallotannin, pentagalloyl glucose, is included. A new method for simultaneous determination of condensed and hydrolyzable tannins is summarized.
Navstar Global Positioning System (2015)

Global positioning system (GPS) was the first operational global satnav system, and is designed and operated to provide service to civilian and to military users. GPS uses advisory messages, called Notice Advisories to Navstar Users (NANUs), to inform users of a change in the GPS constellation. This chapter provides a brief history of GPS and summarizes current plans in the first section, followed by an overview of GPS. Then, it provides detailed characteristics of GPS signals. The development of GPS in the 1970s built upon previously developed and explored technical concepts such as radio navigation from terrestrial transmitters, developments of space-based navigation systems using fundamentally different approaches from GPS, maturation of space-qualified atomic clocks, and application of concepts from digital communications. GPS originally transmitted three signals on two carrier frequencies. Satellites launched since 2005 have gradually added signals and then another carrier frequency.
Key technologies for intelligent and safer cars - From motion estimation to predictive collision avoidance (2010)

One of the research areas that has received more and more interest during the last years is the development of driver assistant systems and semi-autonomous cars. However, densely populated environments like city centers are still a challenge for the operation of such systems. In this paper, we present approaches to two of the major tasks for autonomous driving in urban environments: self-localization and egomotion estimation and detection of dynamic objects such as cars and pedestrians. For each of these tasks we present a summary of the techniques we employ and results on real data. All modules have been implemented and tested on our autonomous car platform SmartTer.
Extraction of Bio‐oils from Microalgae (2009)

A wide variety of terrestrial biomass feed stocks have been identified as suitable candidates for fractionation and conversion into biofuels. In particular, microalgae have been promoted as a future source of transportation fuels primarily because of their stated potential to produce up to 10 times more oil per acre than traditional biofuel crops. Their ability to grow relatively fast, be harvested on a daily basis, and grown in earthen ponds or closed photobioreactors that occupy marginal or poor crop lands using salt or brackish water, are often referenced. When these attractive traits are coupled with the potential to concomitantly harvest valuable co‐products such as biopolymers, proteins, and animal feeds, one can see why microalgae are often touted as biotechnology's “green gold”. The development of large‐scale microalgae farms, however, has been slowed by limitations in downstream processing technology. For example, traditional methods to dewater, extract, and recover bio‐oil from oil‐seeds possess little utility for microalgae. The extreme requirement of dewatering poses tremendous hurdles for any technology processing biofuels from microalgae. To further complicate matters, identifying the most appropriate paths for appropriate extraction technology depends heavily on the microalgal species and its cultivation status, both of which are highly characterized for higher plants as compared to microalgae. In this review we discuss existing extraction methodologies as they have and can be applied to microalgae. Commentary is provided on their potential as a unit operation that exists within the framework of an industrial‐scale microalgal cultivation process that extends from the production of biomass in photobioreactors to the fractionation of the recovered bio‐oil.
Artifacts resembling budding bacteria produced in placer-gold amalgams by nitric acid leaching (1994)

Research Article| December 01, 1994 Artifacts resembling budding bacteria produced in placer-gold amalgams by nitric acid leaching John R. Watterson John R. Watterson 1U.S. Geological Survey, Denver, Colorado 80225 Search for other works by this author on: GSW Google Scholar Author and Article Information John R. Watterson 1U.S. Geological Survey, Denver, Colorado 80225 Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1994) 22 (12): 1144–1146. https://doi.org/10.1130/0091-7613(1994)022<1144:ARBBPI>2.3.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation John R. Watterson; Artifacts resembling budding bacteria produced in placer-gold amalgams by nitric acid leaching. Geology 1994;; 22 (12): 1144–1146. doi: https://doi.org/10.1130/0091-7613(1994)022<1144:ARBBPI>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Microscopic filiform morphologies in gold which are indistinguishable from forms originally interpreted as bacterial in origin were produced in the laboratory by treating amalgams made from natural and artificial gold with hot nitric acid. Textures ranging from cobblestone to deeply crenulated to nodular filiform were produced in the laboratory from all tested natural and artificial gold amalgams; analogous textures widespread in Alaskan placer gold may have a similar inorganic origin. These results indicate that morphology alone cannot be considered adequate evidence of microbial involvement in gold formation. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Condition Assessment of Hydrogenerator Stator Bar Insulation Using Partial Discharge Measurements (2018)

This paper presents results from laboratory measurements of partial discharge (PD) activity in 50 cm long samples cut from the mainwall section of old hydrogenerator stator bars. All stator bars were manufactured in 1976 and samples were taken after 35 years in service from both the low and high voltage sections of the generator, as well as non-energized back-up bars. The PD activity, using a phase resolved (PRPDA) measuring system, was investigated at different test voltages up to 9.6 kV (1.5 U <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ), frequencies and temperatures in the range 20-155 °C and 0.1-50 Hz, respectively. The service-aged and the unaged reference samples showed a clear difference in voltage frequency dependence. It was, however, not possible to distinguish between service-aged bars from high and low electric stress. The observed frequency and temperature dependences are discussed with respect to theoretical assumptions regarding possible void degradation and surface conductivity.
Parametric method for determination of motion characteristics of underwater vehicles, applicable in preliminary designing (2009)

Parametric method for determination of motion characteristics of underwater vehicles, applicable in preliminary designingThis paper describes a method for preliminary designing the autonomous underwater vehicles (AUV), especially useful in the case when requirements concerning kinematic and dynamic parameters of vehicle motion are given in design assumptions. Concept of the method is based on dynamic equations which describe vehicle planar motion in vertical and horizontal directions, resulting from action of screw propellers or water ballast, respectively. The motion equations were determined by applying simplifications concerning both geometrical description of vehicle's form and flow phenomena. Their solutions were obtained in the form of closed analytical expressions which are both of cognitive and practical merits as they can serve to assess influence of vehicle's design parameters on its motion characteristics and simultaneously are convenient to formulate design optimization problems. Application of the method was illustrated by the attached examples dealing with determination of kinematic and dynamic characteristics of motion of the vehicle "Scylla" of set geometrical configuration and propulsion parameters.
Client delegated control within an ASP infrastructure (2001)

Network programmability is a means by which some of the network operator's control is ceded to the network user. While the research community recognizes that networks need to be more programmable to accelerate the speed with which innovation can be introduced, operators have been understandably loath to ‘open up’ their networks until there is some compelling reason to do so. We present a problem: the dynamic creation and modification of Service Level Agreements (SLA) in an Application Service Providers (ASP) infrastructure, which we argue can only be addressed by allowing clients some degree of programmability over that infrastructure. The entity that clients instrument is termed an Instant Corporation or ICorp and encapsulates server, network and proxying devices. We consider the issues involved in a ASP infrastructure which supports such client delegated control through a description of a working implementation called the ICorpMaker.
Influence of Microalloyed SAE 1141 Steel on the Machinability of Drive Shaft Yokes (1989)

&lt;div class="htmlview paragraph"&gt;Microalloyed, resulfurized steel bars were air cooled after forging to compare their machining performance to conventional resulfurized steel forgings. The six-station machining operation is the rate-limiting stage in manufacturing the forgings into drive shaft yokes. Since drilling has the greatest effect on the throughput, drilling thrust force, drilling torque and drilling tool wear was quantified for each type of drive shaft yoke.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Lower thrust forces were obtained while drilling the air cooled, microalloyed forgings. Wear on the drill inserts was so rapid that a steady torque force could not be measured when drilling the heat treated yokes.&lt;/div&gt;
Ullmann‐Reaktionen an ortho‐(Acylamino)halogenaromaten (1977)

Abstract ortho ‐(Acylamino)halogenaromaten 1 und 3 können ohne Aktivierung durch Elektronenakzeptor‐Substituenten mit metallischem Kupfer unter milden Bedingungen in guten Ausbeuten zu symmetrischen Biarylverbindungen 2 und 4 kondensiert werden. Grundsätzlich ist auch die Synthese unsymmetrischer Biarylverbindungen möglich. Vermutlich greift die Acylaminogruppe direkt unter Bildung einer intermediären organischen Kupferverbindung in den Reaktionsablauf ein.
Enhancement of energy density in novel Ba0.67Sr0.33TiO3 nanorod array nanocomposites (2020)

The majority of the previously reported nanocomposites obtainable with higher energy density (>15 J cm−3) relies strongly on much higher breakdown strength (>4000 kV cm−1). The operation of capacitors in such higher applied electric field brings challenges because of the substantially increased the failure probability. In this study we explored the dispersibility and the orientation of fillers in nanocomposites as they play vital roles in the energy density. Based on the infinite element modulation results, an original design of 1–3 type composite structure was employed in the current study. This design adopts the one-dimensional (110)-oriented monodispersed barium strontium titanate Ba0.67Sr0.33TiO3 (BST) nanorod array as fillers embedded in the three-dimensional poly (−vinylidene fluoride) (PVDF) polymer matrix. With these originally designed BST/PVDF nanocomposites, we have demonstrated a significant enhancement of energy density at a lower applied electric field. For example, an energy density of 13.10 J cm−3 at electric field of 3400 kV cm−1 can be obtained, an enhancement of 3 times larger than that of bare PVDF. Moreover, the discharge efficiency is maintained at 69% at 3400 kV cm−1. The high performance of this originally designed nanacomposite demonstrated its potential application in the next generation energy storage devices.
TH-A-WAB-01: Biomarker Sensing (2013)

Purpose: To measure local biomarker concentrations longitudinally over time. Biomarker concentrations can be used to diagnose disease but the most promising application is in monitoring therapy. For example, the VEGF level provides a very direct evaluation of anti-angiogenic therapies or heat shock proteins provide a direct evaluation of thermal therapies. In this effort, the potential of the proposed technology was evaluated for sensitivity and specificity. The potential sensitivity was also estimated. Methods: Magnetic nanoparticles (NPs) can be detected remotely by measuring their magnetization induced by an alternating magnetic field. Magnetic spectroscopy of Brownian motion (MSB) characterizes the rotational Brownian motion from the shape of the magnetization. Rotational Brownian motion characterizes the local microenvironment surrounding the NPs: temperature, viscosity and chemical binding. We are reporting on a novel application of MSB that will allow the local concentration of biomarkers or drugs to be measured in vivo longitudinally over time. Magnetic NPs in ∼200 micron porous walled containers can be deposited in the vascular bed or into the extracellular space via injection in a lesions' blood supply or directly into the lesion. The NPs are decorated so that the target molecule (either biomarker or drug) binds the NPs together into an aggregate. The aggregate has a much longer relaxation time than the free NPs so the MSB signal changes dramatically. The MSB signal can be used to estimate the quantitative concentration of the biomarker. Results: The method has been explored in vitro for the following analytes (minimum sensitivities): 24 mer DNA (100 pM sensitivity); 20 mer DNA (2 nM); thrombin (4 nM); streptavidin (150 pM); VEGF (4 nM). Conclusion: These proof of concept experiments demonstrate that MSB methods are capable of measuring hormone concentrations of biomarkers and would require only reasonable increases in sensitivity to measure cytokine concentrations. NIH-NCI 1U54CA151662-01; Hopeman Fund Grant: Norris Cotton Cancer Center
Efficient disk encryption and verification through trusted nonce (2008)

Approach that integrates encryption and verification is proposed to protect hard disk data. For each data sector, MAC is calculated and the (data sector, MAC) pair is encrypted through the encryption key deduced from the secret root key and a unique nonce. By assuring the nonce to be trusted or untampered through hash tree, data can then be properly decrypted and authenticated. To achieve satisfiable performance, it applies stream cipher to offload the encryption cost, and adopts special structure hash tree with hot-access-windows to fulfill nonce checking efficiently. Ultimately, it can provide data protection with characteristics like solid resistance against any attacks, online working mode, low-level protecting, and high performance. Related model, approaches and system realization are elaborated, as well as testing results. Theoretical analysis and experimental simulations show that it is a practical and available way to build secure disk.
Three new adenosine triphosphate analogs. Synthesis and effects on isolated gut (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree new adenosine triphosphate analogs. Synthesis and effects on isolated gutGeoffrey R. Gough, M. Helen Maguire, and David G. SatchellCite this: J. Med. Chem. 1973, 16, 10, 1188–1190Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/jm00268a028https://doi.org/10.1021/jm00268a028research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Type of LDLR Mutation and the Pharmacogenetics of Familial Hypercholesterolemia Treatment (2015)

Familial hypercholesterolemia (FH) is an autosomal dominant disease mainly caused by mutations in the low-density lipoprotein receptor (LDLR) gene. FH patients present a wide variability regarding response to drugs and they are usually undertreated. Here, we review studies that evaluated the association between the type of LDLR mutation and the response to lipid-lowering therapy. The main findings were that patients with a null LDLR mutation had: higher baseline LDL-C, higher LDL-C after drug therapy, lower proportion of patients within the LDL-C target value and higher frequencies of CVD. Thus, we conclude that FH patients harboring a null mutation have a trend to an increased risk, even if diagnosis is early established and lipid-lowering treatment instituted. It is suggested that these individuals may benefit from the use of newly approved lipid-lowering agents.
Dual Enantioselective Control by Heterocycles of (S)‐Indoline Derivatives (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.