gebhart/patrepeval huggingface dataset:
Steroidal Sapogenins. XLII. Partial Synthesis of 11-Ketodiosgenin2 (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Sapogenins. XLII. Partial Synthesis of 11-Ketodiosgenin2Edward S. Rothman and Monroe E. WallCite this: J. Am. Chem. Soc. 1957, 79, 12, 3228–3231Publication Date (Print):June 1, 1957Publication History Published online1 May 2002Published inissue 1 June 1957https://pubs.acs.org/doi/10.1021/ja01569a062https://doi.org/10.1021/ja01569a062research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Application of adaptive digital down-conversion to underwater acoustic communication with nonuniform Doppler shift (2020)

Abstract In underwater acoustic communication, nonuniform Doppler shift can severely degrade demodulation performance. Nonuniform Doppler shift causes nonuniform phase shifts and variation of received time. In recent studies, a new type of processing was proposed to suppress the effects of the nonuniform time variation. In this paper, we show mathematically how the nonuniform time variation affects communication in conventional demodulation, and describe how the proposed processing works against the time variation. Additionally, we use a simulation to investigate how the proposed processing improves demodulation performance. The simulation is carried out under numerous motional conditions at various symbol rates. The results clearly show the improvement by the proposed processing and clarify the conditions under which the new processing improves performance.
Molecular Cloning and Characterization of Chick SPACRCAN (2006)

MY-174, a monoclonal antibody that reacts with specific sialylated O-linked glycoconjugates of chick SPACR (sialoprotein associated with cones and rods), also recognizes another molecule of 300 kDa. Here, we verified that this 300-kDa molecule is chick SPACRCAN (sialoproteoglycan associated with cones and rods), another member of a novel interphotoreceptor matrix molecule family. Screening for chick SPACRCAN was carried out by plaque hybridization using a probe for chick SPACR. Specific polyclonal antibodies raised against chick SPACRCAN were used for the following experiments. To determine whether the 300-kDa molecule detected by MY-174 was identical to 300-kDa chick SPACRCAN, the migrations of these bands were examined after various glycosidase digestions. Furthermore, the expression levels were measured during retinal development and compared with those of chick SPACR. The results demonstrated that the 300-kDa molecule recognized by MY-174 was chick SPACRCAN, and we further identified it as a proteoglycan with chondroitin sulfate chains. SPACRCAN had heavily sialylated N- and O-linked glycoconjugates, and its MY-174 antigenicity was abolished by O-glycanase treatment after neuraminidase treatment, as observed for chick SPACR. During retinal development, the mRNA and core protein expression levels, MY-174 antigenicity, and hyaluronan binding ability of SPACRCAN peaked around embryonic day 17 and then gradually decreased, whereas the corresponding expression levels of SPACR simply increased, but not its hyaluronan binding ability. The MY-174 reactivity of SPACRCAN in the adult retina was decreased compared with that in the newborn retina, whereas that of SPACR was increased. The decreased hyaluronan binding of SPACR was induced by an inhibitory effect of the excess of sialic acids in the adult stage. Thus, with similar core protein structures and specific sialylated glycoconjugates but distinct chondroitin sulfate chains, SPACRCAN and SPACR may have separate roles in the retina due to their differing expression profiles during development.
The ARIES-III D-/sup 3/He tokamak reactor: design-point determination and parametric studies (2002)

The ARIES-III design uses a D-/sup 3/He fuel cycle and requires advances in technology and physics for economical attractiveness. The optimal design was characterized through systems analysis for eventual conceptual engineering design. Results from the systems analysis are summarized, and a comparison with the high-field, D-T-fueled ARIES-I is included. Both first- and second-stability-region (SSR) options were considered for ARIES-III. SSR design, based on limited experimental results, outperformed the first-stability-region design by a wide margin. Even with full cost credits for safety (level of safety assurance, LSA=1 represents a 25-30% cost credit relative to LSA=4), the SSR ARIES-III is only marginally competitive with median-experience fission power plants and is far from competitive with best-experience fission power plants. The application of the SSR physics to the D-T fuel cycle, however, is expected to produce an ARIES design that is competitive with fissile and fossil power plants.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis (2019)

In conclusion, our findings provide evidence for gray matter network reorganization subsequent to clinical disease manifestation in patients with early RRMS. An adaptive cortical response with increased local network characteristics favoring network segregation could play a primordial role for maintaining brain function in response to neuroinflammation.
A focus+context technique based on hyperbolic geometry for visualizing large hierarchies (1995)

Article Free Access Share on A focus+context technique based on hyperbolic geometry for visualizing large hierarchies Authors: John Lamping Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Ramana Rao Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Peter Pirolli Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile Authors Info & Claims CHI '95: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsMay 1995 Pages 401–408https://doi.org/10.1145/223904.223956Published:01 May 1995Publication History 495citation4,002DownloadsMetricsTotal Citations495Total Downloads4,002Last 12 Months192Last 6 weeks30 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Lipid profiles of conidia of Aspergillus niger and a fatty acid auxotroph (1987)

Conidial lipids of the wild-type (V35) Aspergillus niger and its unsaturated fatty acid auxotroph (UFA2) were compared. The wild type contained lower levels (7.6%) of phospholipids and higher levels (28.4%) of glycolipids than the mutant (16.5 and 22.2%, respectively). Oleic (33.4%), linoleic (22.5%), palmitic (12.8%), stearic (7.4%), and linolenic (6.2%) were the main fatty acids of the wild type (V35). The mutant grew only in the presence of unsaturated fatty acid having at least one delta 9cis double bond, and its conidial fatty acid profile was influenced by the exogenous acid. Analyses of the fatty acids of UFA2 grown in the presence of different fatty acid supplements support the original view that the mutant is defective in delta 9-desaturase activity.
A Disaster Invariant Feature for localization (2010)

In this paper we present a Disaster Invariant Feature (DIF), which is used for localization of Unmanned Aerial Vehicles (UAV). There exist numerous researches that address the problem of localization of UAVs using aerial images. However, after a disaster such as a tornado or an earthquake many features in aerial images like monuments and unique buildings may change, and the image-based localization would become hard or even impossible. Consequently it is important to find features that remain unchanged or with fairly small changes, and can be detected both before and after a disaster. We have used a recent method for street detection from aerial images and shown that road networks and segments are disaster invariant and could be utilized for localization and mapping. The algorithm has been implemented and tested on satellite images from Google, with nearly equivalent resolution to aerial images. The successful result of detecting this DIF on Port-au-Prince, in Haiti, images before and after the recent earthquake is presented.
Fast Return Path Planning for Agricultural Autonomous Terrestrial Robot in a Known Field (2019)

The agricultural sector is becoming more critical than ever in view of the expected overpopulation of the Earth. The introduction of robotic solutions in this field is an increasingly researched topic to make the most of the Earth's resources, thus going to avoid the problems of wear and tear of the human body due to the harsh agricultural work, and open the possibility of a constant careful processing 24 hours a day. This project is realized for a terrestrial autonomous robot aimed to navigate in an orchard collecting fallen peaches below the trees. When it receives the signal indicating the low battery, it has to return to the docking station where it will replace its battery and then return to the last work point and resume its routine. Considering a preset path in orchards with tree rows with variable length by which the robot goes iteratively using the algorithm D*. In case of low battery, the D* algorithm is still used to determine the fastest return path to the docking station as well as to come back from the docking station to the last work point. MATLAB simulations were performed to analyze the flexibility and adaptability of the developed algorithm. The simulation results show an enormous potential for adaptability, particularly in view of the irregularity of orchard field, since it is not flat and undergoes modifications over time from fallen branch as well as from other obstacles and constraints. The D* algorithm determines the best route in spite of the irregularity of the terrain. Moreover, in this work, it will be shown a possible solution to improve the initial points tracking and reduce time between movements.
Enhanced Carrier to Noise Ratio by Brillouin Amplification for Optical Communications (2019)

The limits of narrowband Brillouin gain for improving the carrier to noise ratio (CNR) of spectral lines is evaluated for 64-QAM communications. Calculations of the change in CNR for practical gain, noise, and bandwidth parameters indicate the maximum obtainable CNR enhancement factor and output CNR as being ≈25 dB and ≈40~43 dB/0.1 nm, respectively, limited by the narrowness of the Brillouin gain bandwidth and Brillouin amplifier noise, respectively. These limits determined from the relative power suppression of out of band noise contained within a 10 GHz channel bandwidth are relevant to spectral line amplification either before data modulation at the transmitter, or for a local oscillator (LO) at the receiver for coherent detection. A calibration measurement of the bit error rate (BER) of a 48 Gb/s 64-QAM signal versus CNR of a LO loaded with ASE noise is used to extrapolate the BER from the calculated CNR for Brillouin gain. The results predict the BER being minimally degraded for an input CNR of ≈>20 dB/0.1 nm and falling below the hard decision FEC limit for an input CNR as low as ≈0 dB/0.1 nm. The estimates are found consistent with 64QAM signal experiments of pilot tone carrier recovery by Brillouin gain for both single channel and WDM cases. The insight aids the design and estimation of achievable performance improvement for applying Brillouin amplifiers to coherent communications.
Surfactant-stabilized Emulsion Increases Gentamicin Elution From Bone Cement (2011)

Liquid antimicrobials are released from emulsified antimicrobial-loaded bone cement, but increased strength is needed before this method can be used for implant fixation.
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 (2020)

Abstract Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19) from mild to severe stages including fatality, with pro-inflammatory macrophages as one of the main mediators of lung hyper-inflammation. Therefore, there is an urgent need to better understand the interactions among SARS-CoV-2 permissive cells, macrophage, and the SARS-CoV-2 virus, thereby offering important insights into new therapeutic strategies. Here, we used directed differentiation of human pluripotent stem cells (hPSCs) to establish a lung and macrophage co-culture system and model the host-pathogen interaction and immune response caused by SARS-CoV-2 infection. Among the hPSC-derived lung cells, alveolar type II and ciliated cells are the major cell populations expressing the viral receptor ACE2 and co-effector TMPRSS2, and both were highly permissive to viral infection. We found that alternatively polarized macrophages (M2) and classically polarized macrophages (M1) had similar inhibitory effects on SARS-CoV-2 infection. However, only M1 macrophages significantly up-regulated inflammatory factors including IL-6 and IL-18, inhibiting growth and enhancing apoptosis of lung cells. Inhibiting viral entry into target cells using an ACE2 blocking antibody enhanced the activity of M2 macrophages, resulting in nearly complete clearance of virus and protection of lung cells. These results suggest a potential therapeutic strategy, in that by blocking viral entrance to target cells while boosting anti-inflammatory action of macrophages at an early stage of infection, M2 macrophages can eliminate SARS-CoV-2, while sparing lung cells and suppressing the dysfunctional hyper-inflammatory response mediated by M1 macrophages.
Identification of novel HCV subgenome replicating persistently in chronic active hepatitis C patients (2005)

In an effort to clarify the life cycle of HCV, the HCV genome in liver biopsies taken from chronic active hepatitis C patients undergoing interferon treatment was investigated. Molecular cloning by long distance reverse-transcription polymerase chain reaction (RT-PCR) revealed that the HCV genome in two patients with high viral loads in the liver had in-frame deletions of approximately 2 kb between E1 and NS2, which encode the E1-NS2 fusion protein and six other HCV proteins: core, NS3, NS4A, NS4B, NS5A, and NS5B. Among the remaining 21 chronic active hepatitis C patients, these types of deletion were found in another two patients and in two hepatocellular carcinoma patients. Out-of-frame deletions in the structural region were isolated from the other five patients, but the dominant RT-PCR products were non-truncated genomes. Retrospective analysis of a series of serum samples taken from a patient carrying the subgenome with the in-frame deletion revealed that both the subgenome and the full genome persisted through the 2-year period of investigation, with the subgenome being predominant during this period. Sequence analysis of the isolated cDNA suggested that both the subgenome and the full genome evolved independently. Western blotting analysis of HCV proteins from the HCV subgenome indicated that they were processed in the same way as those from the full genome. HCV subgenomes thus appear to be involved in the HCV life cycle.
Scalable directoryless shared memory coherence using execution migration (2010)

We introduce the concept of deadlock-free migration-based coherent shared memory to the NUCA family of architectures. Migration-based architectures move threads among cores to guarantee sequential semantics in large multicores. Using a execution migration (EM) architecture, we achieve performance comparable to directory-based architectures without using directories: avoiding automatic data replication significantly reduces cache miss rates, while a fast network-level thread migration scheme takes advantage of shared data locality to reduce remote cache accesses that limit traditional NUCA performance. EM area and energy consumption are very competitive, and, on the average, it outperforms a directory-based MOESI baseline by 6.8% and a traditional S-NUCA design by 9.2%. We argue that with EM scaling performance has much lower cost and design complexity than in directory-based coherence and traditional NUCA architectures: by merely scaling network bandwidth from 128 to 256 (512) bit flits, the performance of our architecture improves by an additional 8% (12%), while the baselines show negligible improvement.
Performance Evaluation of Neuro-ITI Canceller Using a Modified Writing Process for TDMR (2013)

The previously-proposed model of the writing process in TDMR is modified based on the Stoner-Wohlfarth reversal mechanism. The BER performance for a neuro-ITI canceller is obtained via computer simulation using the R/W channel model based on the writing process, and it is compared to those for well-known TDMR equalization techniques.
Extracellular HSP90α-LRP1 Signaling Promote Pancreatic Cancer Metastasis and Chemoresistance Via Regulating Epithelial-To-Mesenchymal Transition (2021)

Abstract Extracellular heat shock protein 90α (HSP90α) has been reported to promote cancer cell invasion and migration. However, whether pancreatic cancer (PC) cells expressed membrane-bound or secreted HSP90α and its underlying mechanism for PC progression were still unclear. Our study pointed out that highly invasive Capan2 cells has a higher level of secreted HSP90α, rather than membrane HSP90α, compared with those of less invasive PL45 cells. The conditioned medium of Capan2 cells or recombinant HSP90α protein was able to stimulate the migration and invasion of PL45 or capan2 cells, which could be prevented by a neutralizing anti-HSP90α antibody. Furthermore, secreted HSP90α promoted elements of epithelial-mesenchymal transition (EMT) in PL45 cells, including increases in vimentin and snail expressions, decreases in E-cadherin expression and changes in cell shape towards a mesenchymal phenotype, but these phenomena were reversed by anti-HSP90α antibody in Capan2 cells. In addition, high levels of low-density lipoprotein receptor-related protein 1 (LRP1) mRNA were associated with worsened patient survival in pancreatic adenocarcinoma. LRP1 as a receptor of eHSP90α for its stimulatory role of PC cells EMT and metastasis by activating AKT signaling. Down-regulation of LRP1 could promote chemosensitivity to gemcitabine and doxorubicin, but not to topotecan and paclitaxel in Capan2 cells. Therefore, our study reveals a critical role of secreted HSP90α on EMT events and suggests blocking secreted HSP90α underlies an aspect of metastasis and chemoresistance.
Remarks on rings of quotients (1996)

The first part of the present work introduces a new notion of ring of quotients by any filter of one sided ideals. The construction is a generalization of the one by Gabriel which works for idempotent filters. The second part is devoted to an extension of crossed action of Hopf algebras to such a ring of quotients. The last part comprises an application of this machinery to the question about crossed products being semiprime Goldie.
2.12 Asymmetric Catalysis of Radical Reactions (2021)

Abstract Synthetic methodologies based on radical chemistry are efficient and powerful tools for the construction of carbon–carbon and carbon–heteroatom bonds. This chapter highlights the significance of asymmetric catalysis in free-radical reactions. Several asymmetric catalytic principles, ranging from early chiral Lewis acid and organocatalytic activation to recent photoredox and transition-metal-based asymmetric catalytic systems, are discussed.
Uncertainty in time--frequency representations on finite Abelian groups and applications (2006)

Classical and recent results on uncertainty principles for functions on finite Abelian groups relate the cardinality of the support of a function to the cardinality of the support of its Fourier transforms. We use these results and their proofs to obtain similar results relating the support sizes of functions and their short--time Fourier transforms. Further, we discuss applications of our results. For example, we use our results to construct a class of equal norm tight Gabor frames that are maximally robust to erasures and we discuss consequences of our findings to the theory of recovering and storing signals which have sparse time--frequency representations.
The use of date waste for lactic acid production by a fed-batch culture using <italic>Lactobacillus casei</italic> subsp. <italic>rhamnosus</italic> (2015)

The production of lactic acid from date juice by Lactobacillus caseisubsp. rhamnosus in batch and fed-batch cultures has been investigated. The fed-batch culture system gave better results for lactic acid production and volumetric productivity. The aim of this work is to determine the effects of the feeding rate and the concentration of the feeding medium containing date juice glucose on the cell growth, the consumption of glucose and the lactic acid production by Lactobacillus casei subsp. rhamnosus in fed-batch cultures. For this study, two concentrations of the feeding medium (62 and 100 g/L of date juice glucose) were tested at different feeding rates (18, 22, 33, 75 and 150 mL/h). The highest volumetric productivity (1.3 g/L.h) and lactic acid yield (1.7 g/g) were obtained at a feeding rate of 33 mL/h and a date juice glucose concentration of 62 g/L in the feeding medium. As a result, most of the date juice glucose was completely utilised (residual glucose 1 g/L), and a maximum lactic acid production level (89.2 g/L) was obtained.
Correspondence - Author Reply (2006)

I appreciate the experimental and clinical work carried out by the above workers.In their study, they concluded that antiulcer effect of the extract is due to its antisecretory effect.In their paper [1] they also mentioned that nimbidine isolated from seed kernels of Azadirachta indica is causing reversal of antiulcerogenic effect at higher doses as nimbidine itself is not pure substance but a mixture of different compounds.In our review, we cited the recent references pointing to the antisecreotory activity of Azadirachta indica in addition to mucosal protective effect.