gebhart/patrepeval huggingface dataset:
NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A (2008)

Exofacial phosphatidylserine (PS) is an important ligand mediating apoptotic cell clearance by phagocytes. Oxidation of PS fatty acyl groups (oxPS) during apoptosis reportedly mediates recognition through scavenger receptors. Given the oxidative capacity of the neutrophil NADPH oxidase, we sought to identify oxPS signaling species in stimulated neutrophils. Using mass spectrometry analysis, only trace amounts of previously characterized oxPS species were found. Conversely, 18:1 and 18:0 lysophosphatidylserine (lyso-PS), known bioactive signaling phospholipids, were identified as abundant modified PS species following activation of the neutrophil oxidase. NADPH oxidase inhibitors blocked the production of lyso-PS in vitro, and accordingly, its generation in vivo by activated, murine neutrophils during zymosan-induced peritonitis was absent in mice lacking a functional NADPH oxidase (gp91phox-/-). Treatment of macrophages with lyso-PS enhanced the uptake of apoptotic cells in vitro, an effect that was dependent on signaling via the macrophage G2A receptor. Similarly, endogenously produced lyso-PS also enhanced the G2A-mediated uptake of activated PS-exposing (but non-apoptotic) neutrophils, raising the possibility of non-apoptotic mechanisms for removal of inflammatory cells during resolution. Finally, antibody blockade of G2A signaling in vivo prolonged zymosan-induced neutrophilia in wild-type mice, whereas having no effect in gp91phox-/- mice where lyso-PS are not generated. Taken together, we show that lyso-PS are modified PS species generated following activation of the NADPH oxidase and lyso-PS signaling through the macrophage G2A functions to enhance existing receptor/ligand systems for optimal resolution of neutrophilic inflammation.
Knitted Strain Sensors: Impact of Design Parameters on Sensing Properties (2014)

This paper presents a study of the sensing properties exhibited by textile-based knitted strain sensors. Knitted sensors were manufactured using flat-bed knitting technology, and electro-mechanical tests were subsequently performed on the specimens using a tensile testing machine to apply strain whilst the sensor was incorporated into a Wheatstone bridge arrangement to allow electrical monitoring. The sensing fabrics were manufactured from silver-plated nylon and elastomeric yarns. The component yarns offered similar diameters, bending characteristics and surface friction, but their production parameters differed in respect of the required yarn input tension, the number of conductive courses in the sensing structure and the elastomeric yarn extension characteristics. Experimental results showed that these manufacturing controls significantly affected the sensing properties of the knitted structures such that the gauge factor values, the working range and the linearity of the sensors varied according to the knitted structure. These results confirm that production parameters play a fundamental role in determining the physical behavior and the sensing properties of knitted sensors. It is thus possible to manipulate the sensing properties of knitted sensors and the sensor response may be engineered by varying the production parameters applied to specific designs.
A Study on the Harmonic Contributions of Residential Loads (2011)

This paper presents a measurement technique to determine the harmonic sources and impedances of residential houses at the utility metering point. The results are then applied to quantify harmonic and current contributions of the residential premises. Four residential houses are investigated by using the proposed method. The characteristics of the load-side harmonic impedances and sources are studied, and their harmonic contributions are determined. The results show that voltage distortion is affected mainly by background harmonic sources that exist within the supply system. The current harmonics are affected by the residential loads and the supply system.
gold_20nm_low-concentration water (2017)

single particle tracking of a 20nm gold nanoparticle represented by a single caustic dispersed in water
Quantized embeddings of scale-invariant image features for mobile augmented reality (2012)

Randomized embeddings of scale-invariant image features are proposed for retrieval of object-specific meta data in an augmented reality application. The method extracts scale invariant features from a query image, computes a small number of quantized random projections of these features, and sends them to a database server. The server performs a nearest neighbor search in the space of the random projections and returns meta-data corresponding to the query image. Prior work has shown that binary embeddings of image features enable efficient image retrieval. This paper generalizes the prior art by characterizing the tradeoff between the number of random projections and the number of bits used to represent each projection. The theoretical results suggest a bit allocation scheme under a total bit rate constraint: It is often advisable to spend bits on a small number of finely quantized random measurements rather than on a large number of coarsely quantized random measurements. This theoretical result is corroborated via experimental study of the above tradeoff using the ZuBuD database. The proposed scheme achieves a retrieval accuracy up to 94% while requiring the mobile device to transmit only 2.5 kB to the database server, a significant improvement over 1-bit quantization schemes reported in prior art.
Utility Maximization of Layered Video Multicasting for Wireless Systems with Adaptive Modulation and Coding (2006)

Layered video multicasting can be used to accommodate the heterogeneity of users and their receive channels in wired and wireless system. In a wireless system using adaptive modulation and coding (AMC), total utility of all users can be increased by transmitting the video layers over different AMC modes and allocating proper bandwidth to these video layers. In this paper, it is shown that when the utility function is convex, the utility maximization problem can be formulated into a convex optimization problem. Then several important practical issues like limitation of layer numbers and operational layer rates are considered. With these limitations and no convex constraint on utility function, a genetic algorithm (GA) is proposed to maximize the total utility by layer rate allocation and selecting AMC modes to transmit the video layers. A 7-cell cdma2000 HDR system is used in the simulation to show the performance of the proposed methods.
Essential Oil and Citral Production in Field-Grown Lemongrass in Response to Gamma-Irradiated Chitosan (2017)

A field trial was conducted to study the effect of foliar application (0, 40, 60, 80, and 100 mg.L–1) of irradiated chitosan (ICH) on the growth characteristics, biochemical parameters, and yield and quality attributes of lemongrass (Cymbopogon flexuosus). The lemongrass essential oil (EO) was extracted using Clevenger-type apparatus and analyzed using gas chromatography (GC). ICH at 80 mg.L–1 increased the carbonic anhydrase activity (21.5%), nitrate reductase activity (17.4%), and chlorophyll fluorescence (14.6%); it also increased the content and yield of EO by 36.7% and 98.0%, respectively, and the citral content by 13.5%.
TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice (2004)

IL-1 receptor antagonist–deficient (IL-1Ra–/–) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient IL-1Ra–/– mice did not develop arthritis, and transfer of IL-1Ra–/– T cells induced arthritis in nu/nu mice. Development of arthritis was also markedly suppressed by TNF-α deficiency. We found that TNF-α induced OX40 expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis. These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-α plays an important role in activating T cells through induction of OX40.
Functional differences in human neutrophils isolated pre‐ and post‐prandially (1991)

Activated polymorphonuclear leukocytes have been associated with neoplasia, atherogenesis and reperfusion injury. Since some of these conditions are also correlated with dietary fat, we examined the functional characteristics of leukocytes isolated from subjects before and after consumption of a lipid-rich meal. There was up to 2-fold greater superoxide generation in response to agonists in leukocytes obtained post-prandially; the maximum increase was observed about 4 h after eating and followed the peak (2-4 h) in serum triglycerides. Neutrophils isolated post-prandially also exhibited impaired chemotaxis and defective bacterial killing, but normal phagocytosis. These findings provide a new variable that should be considered in studies of leukocytes.
Use of the Selective Serotonin 3 Receptor Antagonist Ondansetron in the Treatment of Neuroleptic-Induced Tardive Dyskinesia (2000)

Ondansetron may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia.
Supp Table test from Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer (2023)

&lt;p&gt;this is a test&lt;/p&gt;
Comparative Pharmacokinetics and Glucodynamics of Two Human Insulin Mixtures 70/30 and 50/50 insulin mixtures (1994)

Higher insulin concentrations and a greater initial response were present with the 50/50 mixture, but the two mixtures had equivalent bioavailability and cumulative effects. These results support use of the 50/50 mixture in situations where greater initial glucose control is required.
An Overview of Molecular Computing Approaches (Part I) (2004)

Abstract This article reviews recent developments in the area of molecular-scale computing. It describes the construction and operating characteristics of molecular wires, rectifiers, switches, and transistors. It also discusses the concept of molecular gain. Molecular computing architectures based on crosspoint arrays, randomized nanocells, and cellular automata will be discussed in Part II of this article in the November 2004 issue of EDFA.
Unusually short phantom bonds containing Si and P atoms. A theoretical study of 2,4,5-trioxa-1,3-disilabicyclo[1.1.1]pentane and its phosphorus dication analogue (1988)

By means of ab initio calculations, unusually short interatomic distances are predicted between the nonbonded atoms in the title compounds and interpreted in terms of small extent of back electron-donation from the linked oxygens and the accompanying orbital contraction around the nonbonded atoms.
Proinsulin-Specific Autoantibodies Are Relatively Infrequent in Young Offspring With Pre–Type 1 Diabetes (2001)

Insulin is a &amp;beta;-cell&amp;ndash;specific and pivotal autoantigen in type 1 diabetes (1) and is produced after proteolysis of its prohormone proinsulin, which is a potential target of autoimmunity. T-cell studies in the nonobese diabetic (NOD) mouse (2,3) and in prediabetic relatives of patients with type 1 diabetes (4,5) indicate the existence of proinsulin-specific immunodominant epitopes localized in the region between the C-peptide and the A-chain, whereas immune intervention with proinsulin in the NOD mouse can prevent diabetes onset. These studies have led to the proposal of proinsulin as a primary target of autoimmunity associated with type 1 diabetes. At the humoral level, proinsulin-specific autoantibodies have also been reported in humans (6,7). Our own data show, however, that proinsulin autoantibody (PAA) and insulin autoantibody (IAA) levels correlate well in newly diagnosed patients, but IAAs are more sensitive and specific for type 1 diabetes (7). Furthermore, IAA or PAA could be completely displaced with either insulin or &amp;hellip;
Core Genome Responses Involved in Acclimation to High Temperature (2007)

Plants can acclimate rapidly to environmental conditions, including high temperatures. To identify molecular events important for acquired thermotolerance, we compared viability and transcript profiles of Arabidopsis thaliana treated to severe heat stress (45 degrees C) without acclimation or following two different acclimation treatments. Notably, a gradual increase to 45 degrees C (22 degrees C to 45 degrees C over 6 h) led to higher survival and to more and higher-fold transcript changes than a step-wise acclimation (90 min at 38 degrees C plus 120 min at 22 degrees C before 45 degrees C). There were significant differences in the total spectrum of transcript changes in the two treatments, but core components of heat acclimation were apparent in the overlap between treatments, emphasizing the importance of performing transcriptome analysis in the context of physiological response. In addition to documenting increases in transcripts of specific genes involved in processes predicted to be required for thermotolerance (i.e. protection of proteins and of translation, limiting oxidative stress), we also found decreases in transcripts (i.e. for programmed cell death, basic metabolism, and biotic stress responses), which are likely equally important for acclimation. Similar protective effects may also be achieved differently, such as prevention of proline accumulation, which is toxic at elevated temperatures and which was reduced by both acclimation treatments but was associated with transcript changes predicted to either reduce proline synthesis or increase degradation in the two acclimation treatments. Finally, phenotypic analysis of T-DNA insertion mutants of genes identified in this analysis defined eight new genes involved in heat acclimation, including cytosolic ascorbate peroxidase and the transcription factors HsfA7a (heat shock transcription factor A7a) and NF-X1.
Photochemical internalization for the treatment of malignant gliomas (2007)

Photochemical internalization (PCI) is a technique to improve the utilization of macromolecules (e.g. chemotherapeutic agents) in cancer therapy in a site-specific manner. The concept is based on the use of specially designed photosensitizers which localize preferentially in the membranes of endocytic vesicles. Upon exposure to light the photosensitizers induce the formation of reactive oxygen species such as singlet molecular oxygen. The photooxidation of the endocytic membranes leads to the release of the contents of the vesicles into the cytosol. In this way, macromolecules encapsulated by the vesicles will reach the cytosol and exert their biological activity instead of being degraded by lysosomal hydrolases. The utility of PCI for the treatment of malignant gliomas was investigated in vitro using an F98 rat glioma cell line. The cytotoxicity of 5-aminolevulinic acid (ALA) based PCI of bleomycin was compared to: (1) ALA-PDT, and (2) bleomycin. In all cases, monolayers were incubated in ALA, bleomycin, or ALA + bleomycin for 4 hours and were subsequently exposed to 635 nm light. Toxicity was evaluated using colony formation assays. F98 rat glioma cells in monolayer were found to be susceptible to the effects of both ALA-PDT and bleomycin. ALA-PDT was found to be particularly effective when light was delivered at a low irradiance of 5 mW cm<sup>-2</sup>. In this case, a radiant exposure of 20 J cm<sup>-2</sup> resulted in only 4% survival. Bleomycin was found to be toxic at relatively low concentrations, incubation of F98 cells in 10 &mgr;g ml<sup>-1</sup> for 4 hours resulted in 1% survival. The PCI effect was found to be negligible for the parameters investigated in the F98 cell line suggesting that: (1) the incubation time was sub-optimal and/or (2) ALA was inappropriate for this application.
Laser action in para-quaterphenyl vapor pumped by XeCI* laser radiation (1980)

A new approach is proposed to the search for active media involving a theoretical study of the spectral, luminescence, and lasing properties of organic molecules. Laser action was obtained in gas-phase paraquaterphenyl (λ1=361.5 nm) with a low threshold pumping level (1.1 MW/cm2). The lasing capacity of some substituted forms of para-quaterphenyl is predicted.
Precipitation Bchavior of σ Phase in Micro-Duplex Stainless Steel (1978)

Precipitation of σ phase was investigated about two type micro-duplex stainless steels; DSD1H, WS312.Special attention should be paid to change of microstructure during aging.The results obtained are as follows.(1) Precipitation of σ phase is very rapid in micro-duplex stainless steel, especially in WS312.(2) Hardness increases while impact value decreases as σ phase precipitates in micro-duplex stainless steel.(3) Precipitation of σ phase in grain-boundary-reaction (GBR) type in micro-duplex stainless steel. Ferrite phase changes to σ phase and austenite phase to aging.(4) It was observed that ferrite-austenite interface moved prior to σ phase precipitation in DSD1H.No movement of interface was observed in WS312.
Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis (2022)

Tissue (re)vascularization strategies face various challenges, as therapeutic cells do not survive long enough <i>in situ</i>, while the administration of pro-angiogenic factors is hampered by fast clearance and insufficient ability to emulate complex spatiotemporal signaling. Here, we propose to address these limitations by engineering a functional biomaterial capable of capturing and concentrating the pro-angiogenic activities of mesenchymal stem cells (MSCs). In particular, dextran sulfate, a high molecular weight sulfated glucose polymer, supplemented to MSC cultures, interacts with MSC-derived extracellular matrix (ECM) components and facilitates their co-assembly and accumulation in the pericellular space. Upon decellularization, the resulting dextran sulfate-ECM hybrid material can be processed into MIcroparticles of SOlidified Secretome (MIPSOS). The insoluble format of MIPSOS protects protein components from degradation, while facilitating their sustained release. Proteomic analysis demonstrates that MIPSOS are highly enriched in pro-angiogenic factors, resulting in an enhanced pro-angiogenic bioactivity when compared to naïve MSC-derived ECM (cECM). Consequently, intravital microscopy of full-thickness skin wounds treated with MIPSOS demonstrates accelerated revascularization and healing, far superior to the therapeutic potential of cECM. Hence, the microparticle-based solidified stem cell secretome provides a promising platform to address major limitations of current therapeutic angiogenesis approaches.
Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA (2009)

SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.
Supramolecular photosensitive and electroactive materials (2001)

Phthalocyanines: Synthesis, Supramolecular Organization, and Physical Properties Sandwich-Type Phthalocyaninato and Porphyrinato Metal Complexes Electronic Properties of Molecular Organic Semiconductor Thin Films Polydiacetylenes Structural and Optical Properties of Conjugated Molecules in Perhydrotriphenylene (PHTP) and in Other Channel-Forming Inclusion Compounds Charge Transfer Properties of Photosynthetic and Respiratory Proteins Optical and Electronic Properties of Carbon Nitride Polyimides for Microelectronics and Tribology Applications Anomalous Charge Transport and Polarization in Semiconductors Oxides and Porous Film Electrodes Electroactive and Photoactive Dendrimers Electrical Properties of Organic Monolayer Films
AGE-RELATED EYE DISEASES (2008)

Judith S. Young, MLS, is Librarian at Dixon School of Nursing, Abington Memorial Hospital, Willow Grove, PA. Address for correspondence: Dixon School of Nursing, 2500 Maryland Road, Willow Grove, PA 19090 ([email protected]).
Incoherent 2D optical code division multiple access (2004)

Focuses on incoherent 2D optical code division multiple access.
Resolved frequency comb spectroscopy with a 10 GHz Ti:sapphire femtosecond laser (2008)

A 10 GHz passively modelocked Ti:sapphire laser is demonstrated. The associated frequency comb is resolved, and spectroscopy of Rubidium enables the identification of single modes. The spectrum is broadened in microstructured fibers to 250nm.
Diagnostic value of MCM2 immunocytochemical staining in cervical lesions and its relationship with HPV infection. (2015)

Cervical cancer remains the fourth most common cause of cancer-related deaths in women worldwide, and human papillomavirus infection represents the most important risk factor for the development of cervical cancer. Minichromosome maintenance protein-2 has been previously identified by DNA microarray and transcriptional profiling as genes that is overexpressed in cervical carcinomas. 183 cases were enrolled and tested with thin prep liquid-based cytology test. The expressions of human papillomavirus were detected and minichromosome maintenance protein-2 immuncytochemical test was performed on liquid-based pap smears from the samples. Those results were compared with the cervical histopathology results. The positive expression rates of minichromosome maintenance protein-2 and high-risk type human papillomavirus increased with the severity of cervical lesions. The expression level of MCM2 was positively correlated with high-risk types of human papillomavirus. In cervical carcinoma and precancerous lesions, minichromosome maintenance protein-2 was overexpressed and positively correlated with the high risk types of human papillomavirus. As minichromosome maintenance protein-2 immuncytochemical detection was better than genotyping of human papillomavirus, minichromosome maintenance protein-2 may serve as a useful marker in the screening of cervical carcinoma and precancerous lesions and improve the diagnosis of atypical squamous cell of undetermined significance. The joint application can improve the sensitivity and specificity of diagnosis.
Hemibiotrophic infection of Pisum sativum by Colletotrichum truncatum (1993)

The infection of pea ( Pisum sativum ) by Colletotrichum truncatum was studied by light and electron microscopy. These investigations were facilitated by use of an Argenteum pea mutant, which has a readily detachable epidermis. Infection pegs emerging from appressoria penetrated epidermal cells directly. Large intracellular primary hyphae formed a dense stromatic mycelium confined within a single epidermal cell. Primary mycelia gave rise to thinner secondary hyphae which radiated into surrounding cells and caused extensive wall dissolution. Melanized sclerotia developed in the centre of chlorotic water‐soaked lesions. Acervuli were not observed. Epidermal cells survived initial penetration by primary hyphae, as shown by their ability to plasmolyse and accumulate Neutral red, but all infected cells were dead when the secondary hyphae had formed. Six cultivars of pea were susceptible, but seven other legumes were resistant. A single isoform of polygalacturonase with a pI of 8·3 and apparent M r of 40000 was purified from culture filtrates and the TV‐terminal amino acid sequence determined. The relevance of the results to the taxonomy of C. truncatum and the relationships between infection process and host range are discussed.