gebhart/patrepeval huggingface dataset:
Ion detection by Fourier transform ion cyclotron resonance: the effect of initial radial velocity on the coherent ion packet (1989)

Ion detection by Fourier transform ion cyclotron resonance (FT-ICR) is accomplished by observing a coherent ion packet produced from an initially random ensemble of ions. The coherent packet is formed by excitation with a resonant oscillating electric field. Ions that are out of phase with the applied radio frequency (rf) electric field experience a continuous misalignment of the electric field vector. The misalignment creates a net force of the electric field perpendicular to ion motion. The perpendicular component of the rf electric field creates a frequency shift resulting in phase synchronization of the ion ensemble. The phase coherence of the ion packet affects both the sensitivity and the resolution of FT-ICR.
Beampattern optimization by minimization of quartic polynomial (2009)

Beampattern synthesis is a common problem in array signal processing. Recently, methods for beampattern optimization using multiple simultaneously transmitted waveforms have been published in the context of MIMO radar. In this paper, we formulate the beampattern optimization problem as minimization of a multivariate quartic polynomial. The advantage of this approach is that iterative line searches are not needed and that the low-rank case can be solved directly without finding the minima of the full-rank system. The method does not guarantee convergence to the global minimum, but numerical examples provided demonstrate that results comparable to the other approaches are achieved.
Stabilité et dynamique d'un oscillateur endommageable (2004)

ABSTRACT This paper deals with stability of a simple damage oscillator, loaded by a constant traction force. Understanding such an elementary model concerns the seismic behavior of concrete structures. The associated dynamic system is a complex hysteretic system: very few results are available in the literature. Using appropriate internal variables, the dynamic system can be written as a singular autonomous system. Liapounov stability of the numerous solutions is then studied. The differences with the “equivalent” non-linear elastic system are highlighted. The unloading part of the anelastic system has a stabilizing effect.
High-pressure wound irrigation (1985)

The Journal of Wound, Ostomy and Continence Nursing (JWOCN) is the premier publication for wound, ostomy and continence practice and research. The Journal’s mission is to publish current best evidence and original research to guide the delivery of expert health care. The WOCN Society is a professional nursing society which supports its members by promoting educational, clinical and research opportunities to advance the practice and guide the delivery of expert health care to individuals with wounds, ostomies and continence care needs.
Abstract 2620: Progressive expression of n-cadherin and epidermal growth factor receptor in colorectal adenocarcinoma. (2013)

Abstract Purpose: N-cadherin (NCAD) and epidermal growth factor receptor (EGFR) have been found to be inducers of epithelial-to-mesenchymal transition that are known to play a role in invasion and metastasis of cancer. Over expression of NCAD and EGFR are associated with increased tumor invasiveness. However, their progressive expression in colorectal cancer (CRC) has not been studied. Therefore, in the present study, we investigated expression status of NCAD and EGFR in paired lesions of CRC. Experimental Design: We examined the expression of NCAD and EGFR in paired lesions of human CRC (hCRC) and human mice CRC (hmCRC) xenograft by immunofluorescence (IF). Images were acquired using the Olympus FluoView FV1000 (OFVFV1000) Confocal Microscope. The average FITC fluorescence intensity (aFFI) was measured by OFVFV1000 software. Western blot analysis was performed to validate results obtained from IF method. Results: Differential expression pattern of NCAD was observed in paired normal, primary and metastatic lesions of hCRC and hmCRC xenograft tissues. For NCAD, it was mainly localized in cytoplasm (diffused), nucleus (moderate levels), and membrane or cell junctions of CRC. For EGFR, normal colon tissue or primary CRC showing membranous EGFR-low positive staining. In contrast corresponding liver metastasis showing membranous EGFR-high positive staining. The NCAD and EGFR expressions were correlated with metastasis phenotype of hCRC. The expressions of NCAD ((aFFI; 812 vs. 261) and EGFR (aFFI 421 vs.131) were each found to be 3 times higher in liver metastasis of hCRC as compared to primary tumor. It has been observed that the expression of NCAD was substantially increased in metastatic lesion of hmCRC xenograft as compared to primary lesion of hmCRC xenograft. Conclusion: This study revealed that upregulation of NCAD and EGFR expressions is a mechanism by which CRC lesions acquire a more aggressive phenotype and, thereby, progress to a more advanced stage of CRC. Furthermore, our findings are likely to have implications in the design of clinical trials targeting the NCAD and EGFR proteins in CRC. Citation Format: Venkat R. Katkoori, Upender Manne, Marc D. Basson, Harvey L. Bumpers. Progressive expression of n-cadherin and epidermal growth factor receptor in colorectal adenocarcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2620. doi:10.1158/1538-7445.AM2013-2620
Numerical Analysis of Spectral Methods (1977)

This monograph gives a mathematical analysis of spectral methods for mixed initial-boundary value problems. Spectral methods have become increasingly popular in recent years, especially since the development of fast transform methods, with applications in numerical weather prediction, numerical simulations of turbulent flows, and other problems where high accuracy is desired for complicated solutions. The development of a mathematical theory is given that explains why spectral methods work and how well they work.
Supplementary Figure 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner (2023)

&lt;p&gt;PDF file - 75K, H2073 (containing a p53 C242W mutation) was treated for 48 hours with 10 mM JP1201, 1 mM cisplatin, or JP1201 with cisplatin, protein was then harvested, and 70 mg was run onto a 12% SDS-PAGE gel, transferred to nitrocellulose membrane for western blotting. There is no accumulation of p53 after treatment with cisplatin, or JP1201 with cisplatin indicating that p53 in these cells is not activated by DNA damage induced by cisplatin. Additionally, there is no induction of PUMA which is customary when p53 is signaling for apoptosis.&lt;/p&gt;
Hybrid Magnetic–Inductive Angular Sensor with 360° Range and Stray-Field Immunity (2022)

Magnetic and inductive sensors are the dominant technologies in angular position sensing for automotive applications. This paper introduces a new angular sensor: a hybrid concept combining the magnetic Hall and inductive principles. A magnetic Hall transducer provides an accurate angle from 0° to 180°, whereas an inductive transducer provides a coarse angle from 0° to 360°. For this novel concept, a hybrid target with a magnetic and inductive signature is also needed. Using the two principles at the same time enables superior performances, in terms of range, compactness and robustness, that are not possible when used separately. We realized and characterized a prototype. The prototype achieves a 360° range, has a high accuracy and is robust against mechanical misalignments, stray fields and stray metals. The measurement results demonstrate that the two sensing principles are completely independent, thereby opening the doors for hybrid optimum magnetic-inductive designs beyond the usual trade-offs (range vs. resolution, size vs. robustness to misalignment).
The Zoo as Ecotourism Attraction – Visitor Reactions, Perceptions and Management Implications: The Case of Hamilton Zoo, New Zealand (2004)

This paper reports results from a survey of 359 visitors to Hamilton Zoo, New Zealand. The questionnaire comprised items relating to motives for visiting the zoo, and evaluations of attributes, thereby permitting an importance-evaluation approach. The construction of the questionnaire was prompted by zoo management wishing to learn more about what motivated visits, and whether there were perceived deficiencies in visitors' experiences of the zoo. Like other studies (e.g. Turley, 2001) it was concluded that zoos represent an opportunity for family-based trips. However, while some opportunities exist for learning, on the whole visitors were not generally interested in acquiring detailed information about wildlife. Indeed, more importance was attached to the viewing of animals than to the recognition that possibly animals might require 'private places'. These findings prompt a discussion about the extent to which zoos might be able to replace or supplement trips to natural habitats as a means of viewing animals, and concludes that for this to happen significant changes in zoo layout would be required. Additionally, possible implications for zoo management are discussed.
Technologist-Based Implementation of Total Metabolic Tumor Volume into Clinical Practice (2022)

Metabolic tumor volume (MTV) is defined as the total metabolically active tumor volume seen on <sup>18</sup>F-FDG PET/CT examinations. Calculating MTV is often time-consuming, requiring a high degree of manual input. In this study, the MTV calculations of a board-certified nuclear radiologist were compared with those of 2 nuclear medicine technologists. As part of the technologists' educational program, after their classroom time they were trained by the radiologist for 30 min. The technologists calculated MTV within 7.5% of the radiologist's calculations in a set of patients who had diffuse large B-cell lymphoma and were undergoing initial staging <sup>18</sup>F-FDG PET/CT. These findings suggest that nuclear medicine technologists may help accelerate implementation of MTV into clinical practice with favorable accuracy, possibly as an initial step followed by validation by the interpreting physician. The aim of this study was to explore whether efficiency is improved by integrating nuclear medicine technologists into a semiautomated workflow to calculate total MTV.
The tactical Tomahawk conundrum: designing decision support systems for revolutionary domains (2004)

Designing decision support systems for revolutionary domains is problematic because approaches such as cognitive task and work analyses are difficult to implement due to the lack of established domains or users. An example of such a conundrum is the development of in-flight retargeting capabilities for the US Navy's Tomahawk missile. The current version is a "fire-and-forget" missile. However, a new upgrade will allow redirection of missiles in-flight. This new capability means that not only will battlefield commanders have more flexibility, but also that an entire system of human control will be needed where none previously existed. For decision support systems in revolutionary domains like that of the new Tomahawk, the lack of an existing domain makes it difficult to design an effective decision support system. Using the Tomahawk as a case study, this paper demonstrates how the cognitive work analysis can be modified for application to intentional revolutionary domains.
Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide (2001)

Differential fluorescence induction (DFI) in Streptococcus pneumoniae was used as a method for the discovery of genes activated in specific growth environments. Competence stimulatory peptide (CSP) was used as the model inducing system to identify differentially expressed genes. To identify CSP-induced promoters, a plasmid library was constructed by inserting random pieces of S. pneumoniae chromosomal DNA upstream of the promoterless gfpmut2 gene in an Escherichia coli/S. pneumoniae shuttle vector. S. pneumoniae carrying the library were induced with CSP and enriched for green fluorescent protein (GFP)-expressing bacteria using fluorescence-activated cell sorting. A total of 886 fluorescent clones was screened, and 12 differentially activated promoter elements were identified. Sequence analysis of these clones revealed that three were associated with novel competence loci, one of which we show is essential for DNA uptake, and six are known CSP-inducible promoters. We also explored whether competence proteins have a role in virulence and found that mutations in three CSP-inducible genes resulted in attenuated virulence phenotypes in either of two murine infection models. These results demonstrate the utility of DFI as a method for identifying differentially expressed genes in S. pneumoniae and the potential utility of applying DFI to other Gram-positive bacteria.
Emulsifying and Emulsion-Stabilizing Properties of Gluten Hydrolysates (2014)

Gluten is produced as a coproduct of the wheat starch isolation process. In this study, gluten was hydrolyzed to degrees of hydrolysis (DH) of 3-6-10 and 1-2-3 with alcalase and trypsin, respectively. These peptidases have a clearly distinct substrate specificity. Corn oil-in-water emulsions (10 wt % oil) were prepared by high-pressure homogenization at pH 7.5. Gluten peptides with DH 3 proved to be the most effective in producing peptides displaying emulsifying properties. Higher levels of alcalase hydrolysates (2.0 wt %) than of trypsin hydrolysates (1.0 wt %) were required to produce stable emulsions with small droplet sizes, which is attributed to differences in the nature of the peptides formed. The emulsions had small mean droplet diameters (d32 < 1000 nm). Emulsions produced with trypsin hydrolysates (stable after 9 days at 55 °C) displayed better thermal stability compared to those produced with alcalase hydrolysates (destabilized after 2 days at 37 °C). The hydrolysate-containing emulsions, however, were quickly destabilized by salt addition (≤100 mM NaCl) and when the pH approached the isoelectric point of the coated droplets (pH ~5.5). Microscopic analysis revealed the formation of air-in-oil-in-water emulsions at lower hydrolysate concentrations, whereas at higher concentrations (≥3.0 wt %) extensive flocculation occurred. Both phenomena contributed to creaming of the emulsions. These results may be useful for the utilization of gluten hydrolysates in food and beverage products.
Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis (2018)

Traditional lipids did not capture risk of lipid-rich plaque as assessed by NCB, whereas assaying oxidation-modification of lipids revealed significant association with oxidized LDL and oxHDL. The PON-1 activity was increased in psoriasis suggesting possible compensatory antioxidative effect. Psoriasis treatment was associated with a reduction in oxHDL. These findings support performance of larger studies to understand oxidation-modified lipids in inflammatory states.
Application of Stereolithography for Scaffold Fabrication for Tissue Engineered Heart Valves (2002)

A crucial factor in tissue engineering of heart valves is the functional and physiologic scaffold design. In our current experiment, we describe a new fabrication technique for heart valve scaffolds, derived from x-ray computed tomography data linked to the rapid prototyping technique of stereolithography. To recreate the complex anatomic structure of a human pulmonary and aortic homograft, we have used stereolithographic models derived from x-ray computed tomography and specific software (CP, Aachen, Germany). These stereolithographic models were used to generate biocompatible and biodegradable heart valve scaffolds by a thermal processing technique. The scaffold forming polymer was a thermoplastic elastomer, a poly-4-hydroxybutyrate (P4HB) and a polyhydroxyoctanoate (PHOH) (Tepha, Inc., Cambridge, MA). We fabricated one human aortic root scaffold and one pulmonary heart valve scaffold. Analysis of the heart valve included functional testing in a pulsatile bioreactor under subphysiological and supraphysiological flow and pressure conditions. Using stereolithography, we were able to fabricate plastic models with accurate anatomy of a human valvular homograft. Moreover, we fabricated heart valve scaffolds with a physiologic valve design, which included the sinus of Valsalva, and that resembled our reconstructed aortic root and pulmonary valve. One advantage of P4HB and PHOH was the ability to mold a complete trileaflet heart valve scaffold from a stereolithographic model without the need for suturing. The heart valves were tested in a pulsatile bioreactor, and it was noted that the leaflets opened and closed synchronously under subphysiological and supraphysiological flow conditions. Our preliminary results suggest that the reproduction of complex anatomic structures by rapid prototyping techniques may be useful to fabricate custom made polymeric scaffolds for the tissue engineering of heart valves.
Comparisons between silk fibroin nonwoven electrospun fabrics using aqueous and formic acid solutions (2017)

The objective of this study is to compare the spinnability, morphology, structure, mechanical properties, and cell compatibility of the silk fibroin nanofiber nonwoven electrospun fabrics using aqueous (AQ) solution and formic acid (FA) solution. The lower limit concentration was 5 wt% and 3 wt% of AQ solution and FA solution for electrospinning, respectively. The fiber diameter of electrospun fabric using FA solution was larger than that using aqueous solution at the same concentration. The secondary structure contents of silk fabrics were same between AQ and FA solutions. FA was remained in silk nanofibers, and the remained FA could be neutralized. Young’s modulus and cell adhesion on electrospun fabric using FA was lower than that using AQ solution. On the contrary, lower cell proliferation rate on electrospun fabric using FA was kept even after neutralization.
Collagen‐inducing biologization of prosthetic material for hernia repair: Polypropylene meshes coated with polyP/collagen (2017)

Prostethic mesh material such as nonabsorbable polypropylene used in open and laparoscopic hernia repair are characterized by controllable mechanical properties but may elicit undesirable physiological reactions due to the nonphysiological inert polymer material. We succeeded in developing a biocompatible coating for these meshes, based on a physiological inorganic polymer, polyphosphate (polyP) that is morphogenetically active and used as a metabolic energy source, and a collagen matrix. The polyP/collagen hydrogel material was prepared by a freeze-extraction method, with amorphous Ca-polyP microparticles. Electron microscopy (SEM and REM) studies revealed that the polyP/collagen coats are built up of ≈50 nm-sized microparticles deposited onto the collagen matrix which forms a continuous layer around the polypropylene fibers that also spans the mesh pores. This bioresorbable inorganic/organic hybrid coat was found to be degraded during three days of incubation in medium/serum. The biomechanical properties of the coated meshes are comparable to those of the unmodified polypropylene meshes, with a higher toughness in longitudinal orientation and a more pronounced extensibility in the transverse orientation. The polyP/collagen coating improved cell attachment to the polypropylene meshes and strongly increase the growth of fibroblasts (MC3T3-E1 cells). Furthermore, those mats upregulate the expression of the gene encoding the stromal cell-derived factor-1α (SDF-1), a mesenchymal stem cells attracting chemokine in the fibroblasts. We conclude that coating of inert polymer meshes with a biocompatible, collagen-inducing polyP/collagen inorganic/organic hybrid layer may improve tissue integration of the meshes and the outcome of surgical hernia repair and may redudce the foreign body reaction in contaminated field. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2109-2121, 2018.
Preparation and characterization of tapioca starch‐poly(lactic acid)‐Cloisite NA+ nanocomposite foams (2008)

Abstract Tapioca starch, poly(lactic acid), and Cloisite NA + nanocomposite foams, with four clay contents (1, 3, 5, 7, wt %), were prepared by melt‐intercalation method. Selected structural, thermal, physical, and mechanical properties were characterized using X‐ray diffraction (XRD), scanning electron microscopy, differential scanning calorimetry, and an Instron universal testing machine, respectively. XRD results indicated that the 1 wt % nanocomposite foam did not show the characteristic basal reflection of the nanoclay. The 3, 5, and 7 wt % nanocomposite foams produced a mixture of intercalated and tactoid structures. The d 001 ‐spacing of 3, 5, 7 wt % nanocomposite foams produced increases of 11.40, 11.15, and 10.67 Å, respectively, compared to that of the pristine clay. The morphological study showed that the nanocomposite foams exhibited a noticeably reduced cell size, more compact cells, and increased cell density. Increasing clay content caused a decrease in melting temperature ( T m ). Bulk spring index and bulk compressibility were influenced ( P &lt; 0.05) significantly with the addition of different amounts of clay. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Supplementary Materials and Methods from MiR-1 Downregulation Cooperates with MACC1 in Promoting <i>MET</i> Overexpression in Human Colon Cancer (2023)

&lt;p&gt;PDF file - 78K&lt;/p&gt;
Rocket-measured effective recombination coefficients in the disturbedDregion (1975)

The effective recombination coefficient ψ(z) is determined at 2020 UT on November 2(day) and at 0605 UT on November 3 (night) during the November 1969 solar particle event (SPE). Electron and proton spectrum and electron density measurements were all made aboard the same rockets launched at these times from Fort Churchill. These measurements provide the basis for an accurate ψ(z) profile determination up to 90 km for these two specific times. The results are compared directly with those of other workers, and the experimentally observed variation of ψ(z) with ionization rate at night is compared with theoretical predictions.
<p>Daily Consumption of the Collagen Supplement Pure Gold Collagen® Reduces Visible Signs of Aging [Corrigendum]</p> (2020)

[This corrects the article DOI: 10.2147/CIA.S65939.].
Soft-switching study of high-frequency isolated dual-active-bridge resonant DC-DC converter considering harmonic components (2014)

High-frequency isolated dual-active-bridge (DAB) dc-dc converter has two operation modes: synchronous mode and phase shifting mode. In synchronous mode, the output voltage changes in the same extent with the input voltage. In phase shifting mode, the output voltage can remain stable when both the input voltage and the load change. In this paper, the soft switching ranges of the dc-dc converter are analyzed considering the harmonic components. It is more accurate than method which considers the fundamental components only.
Hand controllers for teleoperation. A state-of-the-art technology survey and evaluation (1985)

Hand controller technology for teleoperation is surveyed in three major catagories: (1) hand grip design, (2) control input devices, and (3) control strategies. In the first category, 14 hand grip designs are reviewed and evaluated in light of human factor considerations. In the second, 12 hand controller input devices are evaluated in terms of task performance, configuration and force feedback, controller/slave correspondence, operating volume, operator workload, human limitations, cross coupling, singularities, anthropomorphic characteristics, physical complexity, control/display interference, accuracy, technological base, cost, and reliability. In the third catagory, control strategies, commonly called control modes, are surveyed and evaluated. The report contains a bibliography with 189 select references on hand controller technology.