gebhart/patrepeval huggingface dataset:
Analytical method for calculation of deviations from intended dosages during multi-infusion (2017)

Our method provides insight and predictability in a large range of possible situations involving many variables and dependencies, which is potentially very useful for e.g. the development of a fast, bed-side tool ("calculator") that provides the clinician with a precise prediction of dosing errors and delay times interactively for many scenario's. The interactive nature of such a device has now been made feasible by the fact that, using our method, explicit expressions are available for these situations, as opposed to conventional time-consuming numerical simulations.
Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation (2001)

The present study investigated whether high oestradiol concentrations after ovarian stimulation in infertile women affect endometrial development around the time of implantation. The glandular and stromal components of the endometrium were assessed by morphometric criteria. Endometrial biopsies were taken on day 7 (+/-1) after the ovulating dose of human chorionic gonadotrophin in stimulation cycles and on day 7 after the LH surge in natural cycles. Women (n = 38) undergoing assisted reproduction treatment were evaluated: 12 women in natural cycles, 11 women in stimulation cycles with oestradiol <20,000 pmol/l and failed fertilization after oocyte collection (moderate responders) and 15 women with an oestradiol concentration of > or =20,000 pmol/l in stimulation cycles (high responders). High responders showed delayed glandular maturation and advanced stromal morphology, whereas moderate responders demonstrated synchronous development of glandular and stromal features. In natural cycles, the glands were in phase. The effect of excessively high oestradiol concentrations could be explained by quantitative evaluation of the endometrial biopsies as gland--stromal dyssynchrony, which indicates a deficient secretory transformation of the endometrium that represents a suboptimal endometrial environment for implantation. This substantiates our previous clinical observation of significantly lower pregnancy rates in IVF cycles of women with high oestradiol concentrations (> or =20,000 pmol/l).
Comparison of the Smith-Waterman and Needleman-Wunsch algorithms for online similarity analysis of industrial alarm floods (2020)

Alarm floods are considered to be the major obstacles that prevent the smooth process operations of large-scale industrial facilities. During an alarm flood situation, industrial operators often get confused by too many alarms and thus have difficulties in observing and handling critical alarms. In recent years, sequence alignment based similarity analysis has emerged as an effective way to handle alarm floods. Alarm floods caused by the same fault are very likely to consist of the same group of alarms in a certain sequential order. Conducting realtime sequence alignment of industrial alarm floods can help operators to quickly recall the root cause and make prompt corrective actions. This paper proposes the online similarity analysis of alarm floods based on the Smith-Waterman and Needleman-Wunsch algorithms, and compares their differences and application conditions. Case studies are provided to illustrate the proposed online similarity analysis methods and the differences of the two sequence alignment algorithms.
A Photinus pyralis and Luciola italica Chimeric Firefly Luciferase Produces Enhanced Bioluminescence (2014)

We report the enhanced bioluminescence properties of a chimeric enzyme (PpyLit) that contains the N-domain of recombinant Photinus pyralis luciferase joined to the C-domain of recombinant Luciola italica luciferase. Compared to the P. pyralis enzyme, the novel PpyLit chimera exhibited 1.8-fold enhanced flash-height specific activity, 2.0-fold enhanced integration-based specific activity, 2.9-fold enhanced catalytic efficiency (kcat/Km), and a 1.4-fold greater bioluminescence quantum yield. The results of this study provide an underlying basis of this unusual example of a chimeric enzyme with enhanced catalytic properties that are not simply the sum of the contributions of the two luciferases.
Finger printing on the web (2017)

Nowadays, companies such as Google [1] and Facebook [2] are present on most websites either through advertising services or through social plugins. They follow users around the web collecting information to create unique user profiles. This serious threat to privacy is a major cause for concern, as this reveals that there are no restrictions on the type of information that can be collected, the duration it can be stored, the people who can access it and the purpose of use or misuse. In order to determine if there indeed is any statistically significant evidence that fingerprinting occurs on certain web services, we integrated 2 software namely, FPBlock [6], a prototype browser extension that blocks web-based device fingerprinting, and AdFisher [10], an automated tool that sending out thousands of automated Web browser instances, in such a manner so that the data collected by FP-Block could be fed to AdFisher for analysis.
Phase change measurement of ultrasonic shear waves on reflection from a curing epoxy system (2005)

Simple modelling shows that an ultrasonic shear wave with a frequency in the megahertz range, travelling in an elastic medium, that is subsequently reflected at normal incidence from an interface with a viscous medium will undergo a phase change equivalent to a temporal shift of the order of nanoseconds for realistic material properties. This suggests a new technique to observe and characterize curing epoxy adhesives in a reflection geometry that is preferable in many industrial situations. It has been shown by previous workers that in the case of reflection from a classic viscous liquid only the phase or the amplitude need to be measured in order to return the viscosity of the liquid. This paper explores the more general case for a viscoelastic substance where both amplitude and phase must be measured in order to return the viscosity and elastic modulus of the material under investigation. Non-contact electromagnetic acoustic transducers, generating wideband shear wave pulses in the 0.5–8 MHz frequency range, are used to perform ultrasonic measurements of a shear wave reflected from the interface of an aluminium-curing epoxy resin sample. The viscosity and the shear elastic modulus of the epoxy resin sample are calculated over the cure cycle. As expected the accuracy is limited by significant measurement errors in the reflected amplitude.
IL-6 family cytokines, STAT3 activators, exhibit differential effects in a ligand-specific manner in podocytes (2022)

[Background]
Trypan blue capsule staining to visualizethe capsulorhexis in cataract surgery (1999)

A capsulorhexis may be difficult to perform in the absence of a red fundus reflex. Using 0.1 mL of trypan blue 0.1% to stain the anterior capsule in 30 patients with a mature cataract enabled us to visualize the capsulorhexis during phacoemulsification. No adverse reactions were observed up to 12 months after surgery. Trypan blue staining of the anterior capsule appears to be a safe technique to facilitate the performance of a capsulorhexis in the absence of a red fundus reflex.
Intra-observer and inter-observer variability of clinical annotations of monitoring data (2007)

In order to evaluate new methods for alarm generation from monitoring data, a gold standard of alarm evaluation is needed. Nearly all clinical studies into monitoring alarms used clinician judgement and annotation as the reference standard. We investigated the intra-observer and inter-observer variability between two intensivists in the classification of monitoring time series.
An investigation into the electrochemical oxidation of some aromatic amines in the room-temperature molten salt system aluminum chloride-butylpyridinium chloride (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn investigation into the electrochemical oxidation of some aromatic amines in the room-temperature molten salt system aluminum chloride-butylpyridinium chlorideJ. Robinson and R. A. OsteryoungCite this: J. Am. Chem. Soc. 1980, 102, 13, 4415–4420Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/ja00533a021https://doi.org/10.1021/ja00533a021research-articleACS PublicationsRequest reuse permissionsArticle Views800Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T Cell Receptor Profiling in Type 1 Diabetes (2017)

Advances in acquisition of pancreata and islets from T1D organ donors have facilitated studies of T cells isolated from the target tissues. Immunosequencing of TCR α/β-chain complementarity determining regions, along with transcriptional profiling, offers the potential to transform biomarker discovery. Herein, we review recent studies characterizing the autoreactive TCR signature in T1D, emerging technologies, and the challenges and opportunities associated with tracking TCR molecular profiles during the natural history of T1D.
Picoanalysis: Picoanalysis of Drugs in Biofluids with Quantitative Label‐Free Surface‐Enhanced Raman Spectroscopy (Small 47/2018) (2018)

In article number 1802392, Lev T. Perelman and co-workers report a quantitative label-free surface-enhanced Raman spectroscopy (SERS) method for identifying and quantifying drugs at ultralow concentrations. Self-assembled gold nanoclusters entrap drug molecules and laser light excites the surface plasmon resonance, yielding a large SERS signal from the molecule trapped near the hot spot, allowing measurements of drugs in urine samples at clinically relevant concentrations.
Enabling Unit Testing of Already-Integrated AI Software Systems: The Case of Apollo for Autonomous Driving (2021)

The advanced AI-based software used for autonomous driving comprises multiple highly-coupled modules that are data and control dependent. Deploying those already-integrated software frameworks makes unit testing, a fundamental step in the validation process of critical software, very challenging in safety-critical systems. To tackle this issue, in this paper, we show the steps we followed to develop standalone versions of the modules in an industry-level autonomous driving framework (Apollo) by applying several modifications to its architectural design. We show how the standalone modules have the same functional behavior as their integrated counterpart modules. We exemplify the benefits of standalone modules by performing incremental analysis of the software timing requirements of each module running on a heterogeneous System on Chip (SoC). This is a mandatory step to consolidate and integrate software modules guaranteeing timing constraints (e.g. related to freedom from interference) while maximizing SoC utilization.
Optimal stimulation for CD70 induction on human monocyte‐derived dendritic cells and the importance of CD70 in naive CD4+ T‐cell differentiation (2010)

Studies in mice have shown that CD70 on dendritic cells (DCs) is sufficient to convert T-cell tolerance into immunity and hence induce anti-tumour immune responses. Therefore, it is important to investigate (i) optimal stimuli to induce CD70 on human monocyte-derived DCs (MoDCs), which are widely used for tumour immunotherapy, and (ii) the role of CD70 in functional differentiation of naive CD4(+) and CD8(+) T cells stimulated with MoDCs. We show that interferon-alpha (IFN-alpha) is a key cytokine to differentiate monocytes into DCs with the capacity to express CD70 upon maturation. CD70 expression on IFN-alpha-induced MoDCs was elicited by different categories of maturation-inducing factors (Toll-like receptor ligands, CD40 ligand and pro-inflammatory mediators), among which prostaglandin E(2) was most effective. Naive T cells stimulated with MoDCs also expressed CD70. Stimulation with MoDCs promoted naive CD4(+) T cells to acquire the ability to produce T helper type 1 and 2 cytokines in a CD70-dependent manner. In contrast, the CD70-CD27 interaction diminished the production of an immunoregulatory cytokine IL-10. The CD27 signal did not play a dominant role in the induction of effector molecules in naive CD8(+) T cells during the stimulation with MoDCs. This study adds a novel function to the versatile cytokines, type I IFNs, that is, the induction of CD70 on MoDCs. CD70 promotes naive CD4(+) T cells to acquire immunostimulatory activity through the DC-T-cell and T-cell-T-cell interactions during the stimulation with MoDCs. Hence, the CD70-CD27 interaction may play an important role in inducing effective immune responses in DC-based immunotherapy.
Stabilita charakteristiky odstředivého čerpadla (2011)

Předložená diplomová práce obsahuje teoretický rozbor charakteristik odstředíveho čerpadla, podmínky stability Y(Q) charakteristiky, výpočet charakteristiky ßč(ns), úpravy vedúce k stabilizaci spirálního telesa a oběžného kola, návrh spirály, obežného kola a následný výpočet v programe Fluent.
Treatment of Chronic Granulocytic Leukemia with Chemoradiotherapy and Transplantation of Marrow from Identical Twins (1982)

Twelve patients in the chronic phase of Ph1 (Philadelphia)-positive chronic granulocytic leukemia (CGL) received chemoradiotherapy and marrow from their normal, identical twins. All had a complete remission, with disappearance of all Ph1-positive cells. One patient died of pneumonitis while in remission. Three had a cytogenetic relapse 22 to 30 months after grafting; only one of these three entered blast crisis and died. Eight remain in complete remission 21 to 65 months (median, 30) after transplantation. Thus, the Ph1-positive clone can be ablated and blast crisis delayed or prevented. Of 10 patients with CGL who received transplants during the terminal phase, eight died soon after, one is in complete remission 11 months after receiving a second graft, and one remains in complete remission 71 months after transplantation. This experience suggests to us that every patient with CGL and an identical twin should receive a marrow graft, preferably in the chronic phase. On the basis of our results, trials of allogeneic-marrow transplantation for CGL seem justified.
Go local: The key to controlling the COVID-19 pandemic in the post lockdown era (2020)

The UK government announced its first wave of lockdown easing on 10 May 2020, two months after the non-pharmaceutical measures to reduce the spread of COVID-19 were first introduced on 23 March 2020. Analysis of reported case rate data from Public Health England and aggregated and anonymised crowd level mobility data shows variability across local authorities in the UK. A locality-based approach to lockdown easing is needed, enabling local public health and associated health and social care services to rapidly respond to emerging hotspots of infection. National level data will hide an increasing heterogeneity of COVID-19 infections and mobility, and new ways of real-time data presentation to the public are required. Data sources (including mobile) allow for faster visualisation than more traditional data sources, and are part of a wider trend towards near real-time analysis of outbreaks needed for timely, targeted local public health interventions. Real time data visualisation may give early warnings of unusual levels of activity which warrant further investigation by local public health authorities.
COMPUTER-AIDED PROTEIN DIRECTED EVOLUTION: A REVIEW OF WEB SERVERS, DATABASES AND OTHER COMPUTATIONAL TOOLS FOR PROTEIN ENGINEERING (2012)

The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We will restrict ourselves to overview the availability, usability and limitations of web servers, databases and other computational tools proposed in the last five years. The goal of this review is to provide concise information about currently available computational resources to assist the design of directed evolution based protein engineering experiment.
Tribochemical reactions on FeS2 thin films (2019)

Resumen del trabajo presentado a Ibertriva (X Iberian Conference on Tribology / XI Iberian Vacuum Conference), celebrada en Sevilla (España) del 26 al 28 de junio de 2019.
Elastic modules of soils treated with lignosulfonate (2012)

This paper presents the variation of modulus, in terms of E/qu, with strain for clay soils stabilised by a non-traditional admixture, lignosulfonate. The E/qu has been computed from the stress-strain curves obtained from unconfined compressive strength tests. Lignosulfonate (LS) treated soil shows an increase in the value of E/qu with the addition of LS, especially for soil containing the reactive clay mineral, montmorillonite. The observed variation of E/qu with strain was compared with cement treated soils, and it was found that soils treated with more than 1.0% cement exhibited a decreasing E/qu. Moreover, micro-chemical changes in the soils due to the addition of admixture (e.g. LS &amp; Cement) were captured using electrical conductivity tests. Electrical Conductivity (EC) is found to be increased with LS and decreased over time. This may be due to the formation of clay mineral-lignosulfonate amorphous compounds, which are stable when comes in contact with water. However, cement treated soils showed an increase in EC with curing time, unlike LS that confirmed the existence of unstable compounds (i.e. dissolvable CSH and CASH) resulting in a decrease of E/qu.
A New Neural Architecture for Detecting Urban Changes in Quickbird Imagery (2007)

High-resolution imagery presents a new challenge over other satellite systems in that a relatively large amount of data must be analyzed and corrected for registration and classification errors to identify the land cover changes related to urban development. To obtain the accuracies required by typical applications for wide areas, very extensive manual work is commonly required. In response, we have developed a new method for urban change detection that greatly reduces the human effort needed to analyze the high-resolution imagery. The technique consists in considering a neural network architecture able in parallel to exploit either multitemporal or multispectral satellite information. We found that this new technique is very accurate relative to the results yielded by an image processing approach based on careful visual inspection.
A comparison of stacking with meta decision trees to bagging, boosting, and stacking with other methods (2002)

Meta decision trees (MDTs) are a method for combining multiple classifiers. We present an integration of the algorithm MLC4.5 for learning MDTs in the Weka data mining suite. We compare classifier ensembles combined with MDTs to bagged and boosted decision trees, and to classifier ensembles combined with other methods: voting and stacking with three different meta-level classifiers (ordinary decision trees, naive Bayes, and multi-response linear regression, MLR).
Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions (2011)

The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA lesions is poorly understood. To address this issue, we have studied NER in human HeLa cell extracts of two topologically distinct lesions, one derived from benzo[a]pyrene (10R-(+)-cis-anti-B[a]P-N(2)-dG), and one from the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (C8-dG-PhIP), embedded in either full or 'deletion' duplexes (the partner nucleotide opposite the lesion is missing). All lesions adopt base-displaced intercalated conformations. Both full duplexes are thermodynamically destabilized and are excellent substrates of NER. However, the identical 10R-(+)-cis-anti-B[a]P-N(2)-dG adduct in the deletion duplex dramatically enhances the thermal stability of this duplex, and is completely resistant to NER. Molecular dynamics simulations show that B[a]P lesion-induced distortion/destabilization is compensated by stabilizing aromatic ring system-base stacking interactions. In the C8-dG-PhIP-deletion duplex, the smaller size of the aromatic ring system and the mobile phenyl ring are less stabilizing and yield moderate NER efficiency. Thus, a partner nucleotide opposite the lesion is not an absolute requirement for the successful initiation of NER. Our observations are consistent with the hypothesis that carcinogen-base stacking interactions, which contribute to the local DNA stability, can prevent the successful insertion of an XPC β-hairpin into the duplex and the normal recruitment of other downstream NER factors.
Highly Luminescent CuInS2/ZnS Core/Shell Nanocrystals: Cadmium-Free Quantum Dots for In Vivo Imaging (2009)

Strongly luminescent CuInS2/ZnS core/shell nanocrystals were synthesized from copper iodide, indium acetate, zinc stearate, and dodecanethiol as starting compounds in octadecene solvent. The as-prepared core/shell nanocrystals exhibit a low size distribution (<10%), and present photoluminescence in the range of 550−815 nm with a maximum fluorescence quantum yield (QY) of 60%. Time-resolved fluorescence spectroscopy revealed that the lifetimes of the different spectral components are on the order of hundreds of nanoseconds, indicating that donor−acceptor pair recombinations are at the origin of the observed emission bands. The CuInS2/ZnS nanocrystals were subsequently transferred to the aqueous phase via surface ligand exchange with dihydrolipoic acid and used as fluorescent labels for in vivo imaging. After tail vein injection into nude mice, the biodistribution of the quantum dots was monitored during 24 h using fluorescence reflectance imaging.
ChemInform Abstract: A Low Band Gap Iron Sulfide Hybrid Semiconductor with Unique 2D [Fe16S20]8‐ Layer and Reduced Thermal Conductivity. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Experimental Approach for Engine Mapping (2009)

Both collecting data and constructing of a diesel engine’s specific fuel consumption model by two-stage modeling approach is investigated in this study. The cam angle is swept from minimum to maximum for different engine speed and torque values and, the specific fuel consumption at these points are measured at an engine test bench in a workshop. The different specific fuel consumption models are created by using the collected data and, the best model among these models is chosen by the help of statistical parameters.