gebhart/patrepeval huggingface dataset:
Data on the microstructure and deformation of Fe50Mn25Cr15Co10Nx (x=0∼1.6) supporting the modifications of partial-dislocation-induced defects (PDIDs) and strength/ductility enhancement in metastable high entropy alloys (2021)

The data presented in this article are related to a research paper on the modification of deformed nanostructure and mechanical performance of metastable high entropy alloys (HEAs) [1]. Fe<sub>50</sub>Mn<sub>25</sub>Cr<sub>15</sub>Co<sub>10</sub> alloys with and without nitrogen were synthesized in a vacuum induction furnace using pure metals of 99.99% purity and FeCrN<sub>2</sub> as nitrogen source. The nitrogen content was determined by Leco O/N-836 determinator for nitrogen-doped alloys. Transmission electron microscopy (TEM) were carried at 200 kV equipped with energy dispersive spectroscopy (EDS). Tensile testing was performed at room temperature. The strain rate jump tests were conducted by changing the strain rate between 10<sup>-3</sup> and 10<sup>-2</sup> s<sup>-1</sup> to measure the strain rate sensitivity. The nanostructural evolutions by deformation including extended stacking faults (ESFs), ε-martensite and twins were examined using EBSD and TEM for the annealed samples and those strained to different strain levels. The role of partial dislocations on the formation of various PDIDs were analysed and the energies stored as deformed nanostructure (ESDN) after the PDID band formation were used to predict the evolution of various nanostructure with strain. The data and approach would provide a useful insight into the nanostructural evolution in metastable high entropy alloys.
Viral and Host Responses After Stopping Long-term Nucleos(t)ide Analogue Therapy in HBeAg-Negative Chronic Hepatitis B (2016)

This prospective study investigated viral and host markers after stopping long-term therapy with nucleos(t)ide analogues in noncirrhotic patients with hepatitis B e antigen-negative chronic hepatitis B. After stopping therapy, 13 of 15 patients experienced a virological relapse. Rebound of hepatitis B virus DNA and hepatitis B core-related antigen was associated with induction of plasma tumor necrosis factor, interleukin (IL) 10 , IL-12p70, CXCL10 and subsequent decline in hepatitis B surface antigen (HBsAg), with 20% HBsAg loss after long-term follow-up. The peak levels of hepatitis B virus DNA and hepatitis B core-related antigen after cessation of therapy were positively correlated with the level of HBsAg decline at week 48. Thus, stopping or interrupting NA treatment should be further investigated as a strategy to accelerate HBsAg loss.
ChemInform Abstract: REACTION OF ENAMINES DERIVED FROM CYCLOHEXANONE WITH TETRACYANOETHYLENE (1978)

Abstract Die Cyclohexanonenamine (I) reagieren bei Raumtemp. mit Tetracyanethylen (II) zu den substituierten Tetrahydroindenen (III) (Bildungsmechanismus), deren Struktur durch 13 C‐NMR sowie durch Überführung in die Iminoether (IV) bzw. in das Indenon (V) oder das Tauto‐ mere (VI) bestätigt wird.
A Gas-loaded Free-electron Laser At 600 Å (2005)

The addition of a gas to an FEL wiggler changes the phase velocity of the electromagnetic wave, and so provides a fairly simple way of wavelength tuning. This effect has been demonstrated by reducing the wavelength of an infrared FEL by 0.73 /spl mu/m with the introduction of 200 Torr of hydrogen gas. In this paper, a helium-loaded FEL experiment, which is to operate at /spl lambda/ = 600 /spl Aring/ with /spl gamma/= 220, is proposed, and detailed design calculations are presented. Near the electronic resonance of helium, which occurs at /spl lambda/ = 584 ,k, the index of refraction becomes large, so it is possible to use low gas pressures. This is advantageous because at lower pressures there is less degradation of the beam quality due to multiple scattering. Using typical electron beam parameters, in 115 cm of wiggler length, the power in the wave is increased by a factor of /spl equiv/ 9 at /spl lambda/= 600 /spl Aring/.
Stereotactic radiosurgery for arteriovenous malformations of the basal ganglia and thalamus: an international multicenter study (2019)

SRS is the preferred intervention for the majority of BG and thalamic AVMs. Patients with morphologically compact AVMs that have not been previously embolized are more likely to have a favorable outcome, which may be related to the use of a higher margin dose.
Discovering Tolerance—A Computational Approach to Assess Abiotic Stress Tolerance in Tomato Under Greenhouse Conditions (2022)

Modern plant cultivars often possess superior growth characteristics, but within a limited range of environmental conditions. Due to climate change, crops will be exposed to distressing abiotic conditions more often in the future, out of which heat stress is used as example for this study. To support identification of tolerant germplasm and advance screening techniques by a novel multivariate evaluation method, a diversity panel of 14 tomato genotypes, comprising Mediterranean landraces of Solanum lycopersicum , the cultivar “Moneymaker” and Solanum pennellii LA0716, which served as internal references, was assessed toward their tolerance against long-term heat stress. After 5 weeks of growth, young tomato plants were exposed to either control (22/18°C) or heat stress (35/25°C) conditions for 2 weeks. Within this period, water consumption, leaf angles and leaf color were determined. Additionally, gas exchange and leaf temperature were investigated. Finally, biomass traits were recorded. The resulting multivariate dataset on phenotypic plasticity was evaluated to test the hypothesis, that more tolerant genotypes have less affected phenotypes upon stress adaptation. For this, a cluster-analysis-based approach was developed that involved a principal component analysis (PCA), dimension reduction and determination of Euclidean distances. These distances served as measure for the phenotypic plasticity upon heat stress. Statistical evaluation allowed the identification and classification of homogeneous groups consisting each of four putative more or less heat stress tolerant genotypes. The resulting classification of the internal references as “tolerant” highlights the applicability of our proposed tolerance assessment model. PCA factor analysis on principal components 1–3 which covered 76.7% of variance within the phenotypic data, suggested that some laborious measure such as the gas exchange might be replaced with the determination of leaf temperature in larger heat stress screenings. Hence, the overall advantage of the presented method is rooted in its suitability of both, planning and executing screenings for abiotic stress tolerance using multivariate phenotypic data to overcome the challenge of identifying abiotic stress tolerant plants from existing germplasms and promote sustainable agriculture for the future.
Abstract CT145: A phase I open-label study to evaluate the effect of olaratumab on the pharmacokinetics (PK) of doxorubicin (Dox) in patients with advanced soft tissue sarcoma (STS) (2016)

Abstract Olaratumab (Olara), a fully human monoclonal antibody that selectively binds human platelet-derived growth factor receptor alpha and blocks ligand binding, shows encouraging efficacy in combination with Dox in STS. Patients with metastatic or locally advanced STS not amenable to treatment with surgery or curative radiotherapy, aged ?18 years with an ECOG PS of 0-2 and documented LVE fraction ?50% were included. The primary objective was to assess the effect of Olara on the PK of Dox. Secondary objectives were to further characterize the PK and safety profiles of Olara alone and in combination with Dox. Drug-drug interaction (DDI) was assessed in 21-day cycles, where patients received each drug alone (Cycle 1) then in combination (Cycle 2). In Cycles 3-8, patients with clinical benefit could continue treatment with Olara+Dox. 15-mg/kg Olara was given IV over ∼60 min; 75-mg/m2 Dox was given IV over ∼15 min. Overall, 25 patients (10 male and 15 female, aged 27-83 years) received at least one dose of study drug; as planned, 15 patients were evaluable for PK and DDI assessment. The AUC and Cmax for Dox were similar with or without Olara; the 90% CIs for the ratios of geometric LS means for AUC were within the standard no-effect boundary (0.8, 1.25); the 90% CI for Cmax was only slightly out of the boundary but with a Cmax ratio close to unity (0.984). After the first infusion of Olara alone (Cycle 1, Day 10), a mean Olara Cmax of 293μg/mL was achieved at ∼2h post start of infusion, with a mean t1/2 of ∼157h. The mean Olara CL was 0.0259L/h. After the second infusion (Cycle 2, Day 1, Olara+Dox), Olara serum concentration had a median tmax of ∼2.8h post start of infusion, and the mean Cmax was higher (393μg/mL), due to the residual Olara serum concentrations from cycle 1. The mean t1/2 (∼131h) and CL (0.0218L/h) were, however, similar to those obtained after the first infusion. These Olara PK results are consistent with those previously reported. No deaths occurred. The most common treatment-emergent AE reported during the study were nausea (48%) and fatigue (44%). One Grade 4 IRR was observed; there was no evidence of QT prolongation. IV infusion of Olara did not have a clinically relevant effect on systemic exposure to Dox when both agents were given in combination. The PK of Olara alone and with Dox was consistent with previously reported data. Olara+Dox had an acceptable safety profile Citation Format: Victor Villalobos, Mark Agulnik, Seth M. Pollack, Daniel A. Rushing, Arun Singh, Brian A. Van Tine, Chukwuemeka Okereke, Wee Teck Ng, Damien M. Cronier. A phase I open-label study to evaluate the effect of olaratumab on the pharmacokinetics (PK) of doxorubicin (Dox) in patients with advanced soft tissue sarcoma (STS). [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr CT145.
One-Pot Hydrothermal Synthesis of Multifunctional ZnZrTUD-1 Catalysts for Highly Efficient Direct Synthesis of Butadiene from Ethanol (2021)

The direct conversion of ethanol to butadiene (ETB) is a promising approach for renewable butadiene production. However, simultaneous achievement of high butadiene selectivity and catalyst stability has always been a challenge. Here, the multifunctional ZnZrTUD-1 catalyst possesses both superior catalytic performance and stability in direct ETB conversion. To study the effect of the active centers of catalysts on the catalytic performance, the designed active centers of the catalysts were optimized and further characterized by multiple techniques. One-pot hydrothermal synthesis was utilized to improve the interaction among ZnO, ZrO2, and TUD-1 mesoporous silicate. The results demonstrated that the optimized ZnZrTUD-1 catalyst possessed an excellent ability of resistance to carbon deposition and exhibited a synergistic catalysis effect. When the reaction was conducted at 400 °C and a weight hourly space velocity of 0.38 h–1, the catalytic performance revealed that it generated an outstanding butadiene selectivity of 62.5% and an ethanol conversion of 84.6%, which still remained stable during 50 h on stream.
Cryptococcus rajasthanensis sp. nov., an anamorphic yeast species related to Cryptococcus laurentii, isolated from Rajasthan, India (2007)

Two novel anamorphic yeast strains (S-15LT and 3-C1) were isolated from the inflorescences of plants collected in two different towns in Rajasthan State, India. Sequencing of the D1/D2 domains of the large-subunit (LSU) rDNA and the internal transcribed spacer (ITS) regions suggested they are strains of the same species. Phenotypic characteristics such as the absence of fermentation, the absence of sexual structures and ballistoconidia, the assimilation of myo-inositol and d-glucuronate, and positive Diazonium blue B and urease reactions indicated that these strains belong to the genus Cryptococcus. The novel strains differed from Cryptococcus laurentii in six physiological tests and differed from other related species in more than six tests. A phylogenetic analysis of the sequences of the D1/D2 domains of the LSU rDNA and the ITS regions placed these strains in the Bulleromyces clade within the order Tremellales, with C. laurentii as their closest described relative. The novel strains showed 1.6 and 7.5 % divergence in the D1/D2 domain of the LSU rDNA and ITS regions, respectively, with respect to C. laurentii. The divergence from other species was more than 3 % for the D1/D2 domain and more than 9 % for the ITS region. On the basis of the phenotypic and molecular data, strains S-15LT and 3-C1 represent a novel species within the genus Cryptococcus, for which the name Cryptococcus rajasthanensis sp. nov. is proposed. The type strain is S-15LT (=MTCC 7075T=CBS 10406T).
Front Matter: Volume 6977 (2008)

This PDF file contains the front matter associated with SPIE Proceedings Volume 6977, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and the Conference Committee listing.
IBM Watson: How Cognitive Computing Can Be Applied to Big Data Challenges in Life Sciences Research (2016)

Life sciences researchers are under pressure to innovate faster than ever. Big data offer the promise of unlocking novel insights and accelerating breakthroughs. Ironically, although more data are available than ever, only a fraction is being integrated, understood, and analyzed. The challenge lies in harnessing volumes of data, integrating the data from hundreds of sources, and understanding their various formats. New technologies such as cognitive computing offer promise for addressing this challenge because cognitive solutions are specifically designed to integrate and analyze big datasets. Cognitive solutions can understand different types of data such as lab values in a structured database or the text of a scientific publication. Cognitive solutions are trained to understand technical, industry-specific content and use advanced reasoning, predictive modeling, and machine learning techniques to advance research faster. Watson, a cognitive computing technology, has been configured to support life sciences research. This version of Watson includes medical literature, patents, genomics, and chemical and pharmacological data that researchers would typically use in their work. Watson has also been developed with specific comprehension of scientific terminology so it can make novel connections in millions of pages of text. Watson has been applied to a few pilot studies in the areas of drug target identification and drug repurposing. The pilot results suggest that Watson can accelerate identification of novel drug candidates and novel drug targets by harnessing the potential of big data.
A high-performance embedded DSP core with novel SIMD features (2003)

A low-power, high-performance, compiler-friendly DSP core has been under development in the IBM Communications Research & Development Center, as part of its eLite DSP project. This DSP incorporates instruction-level parallelism through the packing of multiple instructions in 64-bit long-instruction words, while data-level parallelism is realized through the use of SIMD techniques, such that SIMD operations can be applied to both dynamically composed vectors and packed vectors. Dynamic composition of vectors is made possible through the use of a vector pointer mechanism, which permits the addressing in a very flexible way of groups of four 16-bit elements in a large, multiport, scalar register file. This paper provides an overview of the architecture of this DSP core, with a focus on its SIMD features. We describe these features in some detail and discuss how they are used, with a block FIR filter and a radix-4 FFT taken as examples.
GaN-Based High-Power-Density Electrolytic-Free Universal Input LED Driver (2018)

This paper presents a high-power-density high-power-factor GaN-based two-stage electrolytic-free offline LED driver. The LED driver achieves high power density through the use of a hybrid film-ceramic stacked switched capacitor (SSC) energy buffer, and a comprehensive optimization methodology that evaluates various converter topologies and designs and minimizes overall system volume while maintaining high efficiency. Based on this optimization approach, a totem-pole bridgeless boost power factor correction (PFC) converter is selected for the first stage, while a stacked-input isolated LLC dc-dc converter is selected for the second stage. The optimization procedure also minimizes the passive volume of the SSC energy buffer incorporating the volumetric energy density of commercially available capacitors. The optimized SSC energy buffer utilized in the proposed LED driver has 50% less passive volume than a capacitor-only solution. A 600-W prototype LED driver designed using the proposed approach for universal input voltage (90 - 305 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ) and 24-V output voltage is built and tested. The PFC stage achieves a peak efficiency of 98% while the LLC stage achieves a peak efficiency of 95%. The prototyped LED driver achieves a power density of 28 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Prognostic factors for the effect of a myofeedback-based teletreatment service (2010)

We investigated the potential prognostic factors for clinically relevant improvements in pain intensity and pain-related disability after myofeedback-based teletreatment. Sixty-five female computer users, 56 female patients with whiplash-associated disorders and 18 female patients with non-specific neck and shoulder pain participated in the study. They received myofeedback-based teletreatment or usual treatment. Questionnaires concerning prognostic factors, pain and disability were completed before the start of the intervention (baseline) and at follow-ups at the end of the intervention, and after 3 and 6 months. Logistic regression analyses were performed in order to investigate prognostic factors for clinically relevant improvement. In the intervention group, improvement in pain intensity was predicted by baseline pain intensity. Baseline pain intensity and disability, and fear-avoidance and endurance related pain coping responses were prognostic factors for outcome in pain-related disability in this group. There were few differences between the intervention groups; fear-avoidance coping responses influenced the outcome after teletreatment only. Myofeedback-based teletreatment appears to be an useful telemedicine intervention, especially for participants with moderate to high levels of pain and disability, high perceived help/hopelessness, and those who tend to deal with their pain by avoiding social and physical activities.
Probing thin-film morphology of conjugated polymers by Raman spectroscopy (2010)

We use Raman spectroscopy to investigate the thin-film morphology of conjugated polymers [poly(9,9-di-n-octylfluorene-alt-benzothiadiazole (F8BT)] in terms of the polymer chain conformation at interfaces with quartz, a crosslinked benzocyclobutene derivative, polyvinylphenol, and poly(3,4-ethylenedioxythiophene):poly(styrenesulphonate). The polymer chains near the substrate interface adopt a more planar conformation (lower torsion angle between fluorene and benzothiadiazole units) than chains in the bulk of the film for all substrates studied. On annealing, polymer chains both near the interface and in the bulk of the film adopt more planar conformations than in their pristine states but to a different degree. The influence of F8BT molecular weight on polymer chain conformation near the substrate interface is also examined. These results are confirmed by additional absorption and photoluminescence measurements.
Choice-based Pricing for User-Provided Connectivity? (2015)

User-provided connectivity (UPC) leverages the network connectivity of its users to build a service offering that goes beyond their individual connectivity option, i.e., allows them to roam. Because the service's overall value typically grows as a function of its coverage, it is important to devise pricing policies that make it attractive to all users, even those who derive little value from roaming. This paper builds on earlier work that explored the value of a UPC service, and proposes a new pricing policy, the Price choice policy, that seeks to realize an effective compromise between pricing complexity and the policy's ability to maximize system value and extract profit. The paper illustrates the benefits of the proposed policy by demonstrating why and how it outperforms several previously proposed policies.
Ferredoxin‐thioredoxin reductase: A chromophore‐free protein of chloroplasts (1979)

FEBS LettersVolume 107, Issue 1 p. 141-145 Full-length articleFree Access Ferredoxin-thioredoxin reductase: A chromophore-free protein of chloroplasts Angel De La Torre, Angel De La Torre Department of Cell Physiology, University of California, Berkeley, CA 94720, USASearch for more papers by this authorCatalina Lara, Catalina Lara Department of Cell Physiology, University of California, Berkeley, CA 94720, USASearch for more papers by this authorRicardo A. Wolosiuk, Ricardo A. Wolosiuk Department of Cell Physiology, University of California, Berkeley, CA 94720, USA Present address: Fundacion Campomar, Buenos Aires, Argentina Search for more papers by this authorBob B. Buchanan, Corresponding Author Bob B. Buchanan Department of Cell Physiology, University of California, Berkeley, CA 94720, USAAddress correspondence to: Professor Bob B. Buchanan, Department of Cell Physiology, 313 Hilgard Hall, University of California, Berkeley CA 94720, USASearch for more papers by this author Angel De La Torre, Angel De La Torre Department of Cell Physiology, University of California, Berkeley, CA 94720, USASearch for more papers by this authorCatalina Lara, Catalina Lara Department of Cell Physiology, University of California, Berkeley, CA 94720, USASearch for more papers by this authorRicardo A. Wolosiuk, Ricardo A. Wolosiuk Department of Cell Physiology, University of California, Berkeley, CA 94720, USA Present address: Fundacion Campomar, Buenos Aires, Argentina Search for more papers by this authorBob B. Buchanan, Corresponding Author Bob B. Buchanan Department of Cell Physiology, University of California, Berkeley, CA 94720, USAAddress correspondence to: Professor Bob B. Buchanan, Department of Cell Physiology, 313 Hilgard Hall, University of California, Berkeley CA 94720, USASearch for more papers by this author First published: November 01, 1979 https://doi.org/10.1016/0014-5793(79)80482-2Citations: 19 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume107, Issue1November 01, 1979Pages 141-145 ReferencesRelatedInformation
Association between polymorphisms in leptin, leptin receptor, and β-adrenergic receptor genes and bone mineral density in postmenopausal Korean women (2013)

These results suggest that the LEPR c.1968G>C polymorphism may be one of the genetic factors affecting femoral neck BMD in postmenopausal Korean women and that an analysis of the ADRB2 c.46A>G polymorphism may be useful in identifying women at risk for osteoporosis at the femoral neck.