gebhart/patrepeval huggingface dataset:
Physicians' reactions to learning style and personality type inventories (1998)

There are a multitude of learning style and personality type inventories available for use in the medical setting. We wanted to know how physicians and physician educators view learning style and personality type inventories, i.e. the relative value and usefulness of the inventories from the physician's perspective. Our continuing medical education (CME) intervention consisted of a three-hour workshop on the Kolb Learning Style Inventory (LSI), the Myers-Briggs Type Indicator (MBTI), and the Hemispheric Mode Indicator (HMI). We interviewed participants one month after the workshop regarding their reactions to the inventories, including what it was like for them to take the inventories, whether they felt inventory results are relevant to medical practice and teaching, and their actual and/or anticipated behavioral changes with respect to medical practice and teaching as a result of their participation in the workshop. Physicians found the inventories interesting and fun to take. They thought the styles and types of information were applicable in patient care and education, practice management and administration, and medical education. They generally agreed that one month was not enough time to fully reflect on and act upon the ideas and concepts presented in the workshop. Requests for further information and training on how to use inventory results suggest topics and formats for future CME programming.
Preparation and Chelating Properties of 4-Bromosalicylic Acid-Formaldehyde Polymers. Part II (1982)

Abstract 4-Bromosalicylic acid (BS) was condensed with various proportions of formaldehyde using different acid catalysts. The polymer samples have been characterized by IR spectral studies, by their number-average molecular weight (M n), and by TGA. Viscosity measurements of selected polymer samples in DMF showed that their solutions exhibited polyelectrolyte behavior. The intrinsic viscosity [η] of the polymer samples were measured in 80:20 (v/v) DMF/water containing 1% KBr, a medium in which the polymers exhibited normal behavior. Metal chelates of one polymer sample are characterized. Ion-exchanging properties of the same sample are studied by application of the batch equilibrium method
Mild and Efficient Flavin-Catalyzed H2O2 Oxidations (2001)

Based on a previously discovered method for amine oxidations using flavins as catalysts and hydrogen peroxide as oxidant, a comparative kinetic study using NMR spectroscopy was undertaken with a series of flavins for amine and thioether oxidations. Included in this series is the newly prepared 7,8-difluoro-1,3-dimethyl-5-ethyl-5,10-dihydroalloxazine. This study shows that flavins, which bear electron-donating groups on the aromatic ring and/or the N-10 position, are less active and are deactivated during the course of the reaction. Moreover, flavins that are alkylated at the N-1 position instead of the N-10 position and having either no substituents or electron-withdrawing groups on the aromatic ring, remain the most active and stable.
Precise control of epitaxy of graphene by microfabricating SiC substrate (2012)

Epitaxial graphene (EG) on SiC is promising owing to a capability to produce high-quality film on a wafer scale. One of the remaining issues is microscopic thickness variation of EG near surface steps, which induces variations in its electronic properties and device characteristics. We demonstrate here that the variations of layer thickness and electronic properties are minimized by using microfabricated SiC substrates which spatially confines the epitaxy. This technique will contribute to the realization of highly reliable graphene devices.
Amount and Type of Leukocytes in ‘Leukocyte-Free’ Red Cell andPlatelet Concentrates (1987)

The exact number ofleukocytes remaining in ‘leukocyte-free’ red cell and platelet concentrates cannot be measured by standard methods. We have therefore developed methods to harvest all the leukocytes from blood components. The leukocytes were then counted and identified using monoclonal antibodies. The leukocyte-free red cell concentrates were prepared by combining buffy coat removal and filtration through a Cellselect filter. The mean number ofleukocytes per unit was 1,0 x 10^5. Most of the leukocytes were granulocytes and T cells. Only a few B cells or monocytes could be detected. Leukocyte-free platelets were prepared by filtering 4 units of PC through a cotton-wool (Imugard) filter. The mean number of leukocytes per PC unit was 0.4 x 10^5 of which 85-95% were T cells.
Altered proteoglycan gene expression and the tumor stroma (1994)

Tumor stroma is a specialized form of tissue that is associated with epithelial neoplasms. Recent evidence indicates that significant changes in proteoglycan content occur in the tumor stroma and that these alterations could support tumor progression and invasion as well as tumor growth. Our main hypothesis is that the generation of tumor stroma is under direct control of the neoplastic cells and that, via a feedback loop, altered proteoglycan gene expression would influence the behavior of tumor cells. In this review, we will focus primarily on the work from our laboratory related to the altered expression of chondroitin sulfate proteoglycan and its role in tumor development and progression. The connective tissue stroma of human colon cancer is enriched in chondroitin sulfate and the stromal cell elements, primarily colon fibroblasts and smooth muscle cells, are responsible for this biosynthetic increase. These changes can be reproduced in vitro by using either tumor metabolites or co-cultures of human colon carcinoma cells and colon mesenchymal cells. The levels of decorin, a leucine-rich proteoglycan involved in the regulation of matrix assembly and cell proliferation, are markedly elevated in the stroma of colon carcinoma. These changes correlate with a marked increase in decorin mRNA levels and a concurrent hypomethylation of decorin gene, a DNA alteration associated with enhanced gene expression. Elucidation of decorin gene structure has revealed an unexpected degree of complexity in the 5' untranslated region of the gene with two leader exons that are alternatively spliced to the second coding exon. Furthermore, a transforming growth factor beta (TGF-beta)-negative element is present in the promotor region of decorin gene.(ABSTRACT TRUNCATED AT 250 WORDS)
Genotype of 88Toxoplasma gondiiIsolates Associated with Toxoplasmosis in Immunocompromised Patients and Correlation with Clinical Findings (2009)

We report the genotyping analysis of Toxoplasma gondii isolates in samples collected from 88 immunocompromised patients, along with clinical and epidemiological data. Most of these samples were collected in France during the current decade by the Toxoplasma Biological Resource Center. Lack of specific anti-Toxoplasma treatment, pulmonary toxoplasmosis, and involvement of multiple organs were the 3 main risk factors associated with death for this patient group. Genotyping results with 6 microsatellite markers showed that type II isolates were predominant among patients who acquired toxoplasmic infection in Europe. Non-type II isolates included 13 different genotypes and were mainly collected from patients who acquired toxoplasmosis outside Europe. Type III was the second most common genotype recovered from patients, whereas type I was rare in our population. Three nonarchetypal genotypes were repeatedly recovered from different patients who acquired the infection in sub-Saharan Africa (genotypes Africa 1 and Africa 2) and in the French West Indies (genotype Caribbean 1). The distribution of genotypes (type II vs. non-type II) was not significantly different when patients were stratified by underlying cause of immunosuppression, site of infection, or outcome. We conclude that in immunocompromised patients, host factors are much more involved than parasite factors in patients' resistance or susceptibility to toxoplasmosis.
Mining frequent item sets by opportunistic projection (2002)

In this paper, we present a novel algorithm Opportune Project for mining complete set of frequent item sets by projecting databases to grow a frequent item set tree. Our algorithm is fundamentally different from those proposed in the past in that it opportunistically chooses between two different structures, array-based or tree-based, to represent projected transaction subsets, and heuristically decides to build unfiltered pseudo projection or to make a filtered copy according to features of the subsets. More importantly, we propose novel methods to build tree-based pseudo projections and array-based unfiltered projections for projected transaction subsets, which makes our algorithm both CPU time efficient and memory saving. Basically, the algorithm grows the frequent item set tree by depth first search, whereas breadth first search is used to build the upper portion of the tree if necessary. We test our algorithm versus several other algorithms on real world datasets, such as BMS-POS, and on IBM artificial datasets. The empirical results show that our algorithm is not only the most efficient on both sparse and dense databases at all levels of support threshold, but also highly scalable to very large databases.
Effect of agitation of BACTEC 13A blood cultures on recovery of Mycobacterium avium complex (1991)

The effect of agitation of BACTEC 13A bottles (Becton Dickinson) on the recovery of Mycobacterium avium complex (MAC) from blood was compared with that of static incubation. A total of 265 blood specimens was inoculated in duplicate into BACTEC 13A bottles. One specimen was statically incubated at 35 degrees C, and the other was incubated with agitation on a Gyrotory shaker at 35 degrees C for the first 2 weeks and thereafter without shaking for up to 12 weeks. Of the 265 specimens, 77 (29.1%) were positive in either one or both of the paired bottles. The average detection times for the shaken and nonshaken bottles were 12.7 and 15.9 days, respectively. A total of 10.4% of the specimens in the shaken bottles became positive 1 week before those in the nonshaken bottles, and 16.9% of the shaken cultures were positive more than 2 weeks before their counterparts. A further 46.8% of the agitated specimens became positive while the corresponding nonagitated cultures remained negative. When both specimens became positive at the same time, 88% of the shaken cultures had higher growth indices than their nonshaken counterparts. A further 11 paired blood cultures were taken from patients known to be infected with MAC to assess the effect of agitation of bottles on the utility of making twice-weekly readings during the first 2 weeks of incubation. Ten of the 11 sets of specimens in the shaken bottles were positive 1 or more weeks before those in the corresponding nonshaken bottles. In the remaining set, both specimens became positive on the same day; however, the growth index of the agitated culture was higher.(ABSTRACT TRUNCATED AT 250 WORDS)
Disease-on-a-chip: mimicry of tumor growth in mammary ducts (2013)

We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces. Moreover, tumor nodules cocultured with the luminal epithelium in hemichannels display a different anticancer drug sensitivity compared to nodules cocultured with the luminal epithelium on a flat surface and to monocultures of tumor nodules. The mimicry of tumor development within the epithelial environment of mammary ducts provides a framework for the design and test of anticancer therapies.
Design Methodology for Wideband Bowtie Patch Antenna for 5G mmWave Applications (2023)

Millimeter wave (mmWave) frequencies has become a research area of interest in recent years because of providing broad available bandwidth and thus higher data rates. Wideband mmWave antenna is one of the important development areas in wireless communication systems. Bowtie patch is a low profile planar antenna with wideband characteristics. This contribution presents a classic design method for bowtie patch antenna in mmWave frequencies for the purpose of achieving maximum possible bandwidth and compactness, based on the combination of patch antenna and bowtie antenna theories. The proposed method is illustrated with the design of a dual polarized antenna element that can be a good candidate for mmWave wireless technologies such as 5G, radar and satellite communications. The design performance has been compared with the recent similar literary works and shows advantageous in terms of bandwidth and size.
Consequences of introducing a disulfide bond into an antibacterial and hemolytic peptide (1999)

The effect of introducing a disulfide bridge between the N- and C-terminal ends on the structure and biological activities of the 13-residue linear peptide PKLLKTFLSKWIG(SPFK), which has both antibacterial and hemolytic activity, have been investigated. The terminal amino acids P and G in SPFK were replaced by cysteines to form a disulfide bridge. The linear peptides C(Acm)KLLKTFLSKWIC(Acm) and C(Acm) KLLKTFLSKWIC(Acm)-amide, where Acm is acetamidomethyl group, showed antibacterial activity but did not possess hemolytic activity unlike SPFK. Introduction of an S-S bridge resulted in enhanced hemolytic activity compared with SPFK. The hemolytic activity was particularly pronounced in the cyclic peptide CKLLKTFLSKWIC-amide. Circular dichroism studies indicate that the cyclic peptides tend to adopt distorted helical structures. The cyclic peptides also have a greater affinity for lipid vesicles, which could be the reason for the effective perturbation of the erythrocyte membrane.
An alpha‐defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft‐versus‐host disease (2020)

We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri-engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II-IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28-1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.
The Effect of Raindrops on the Automotive On-Glass Antenna (2022)

In this paper, we evaluate the effect of raindrops on the on-glass antennas in order to make the design more efficient. Automotive glass has a three-layer structure with an interlayer film in between to prevent shattering. A dipole antenna was placed on the lower center surface of a 300 mm $\times300$ mm glass sheet, and the electromagnetic field analysis was conducted using a model in which raindrops adhered to the antenna. The results show that raindrops have little effect on the reflection coefficient of the antenna. However, if the raindrops flow in the same direction as the antenna and form streaks, the reflection coefficient worsens. Both raindrops and rain streaks were found to affect the radiation pattern.
Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions (2011)

UV irradiation of cellular DNA leads to the formation of a number of defined mutagenic DNA lesions. Here we report the discovery of new intrastrand C(4-8)G and G(8-4)C cross-link lesions in which the C(4) amino group of the cytosine base is covalently linked to the C(8) position of an adjacent dG base. The structure of the novel lesions was clarified by HPLC-MS/MS data for UV-irradiated DNA in combination with chemical synthesis and direct comparison of the synthetic material with irradiated DNA. We also report the ability to generate the lesions directly in DNA with the help of a photoactive precursor that was site-specifically incorporated into DNA. This should enable detailed chemical and biochemical investigations of these lesions.
Supplementary Figure 3 from The β<sub>2</sub>-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells (2023)

&lt;p&gt;Therapy resistance shADRB2 cell lines&lt;/p&gt;
Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers (2016)

Significant subsets of patients with oral cancer fail to respond to single-agent programmed death (PD) blockade. Syngeneic models of oral cancer were used to determine if blocking oncogenic signaling improved in vivo responses to PD-L1 monoclonal antibody (mAb). Anti-PD-L1 enhanced durable primary tumor control and survival when combined with mTOR (rapamycin), but not in combination with MEK inhibition (PD901) in immunogenic MOC1 tumors. Conversely, PD-L1 mAb did not enhance tumor control in poorly immunogenic MOC2 tumors. Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNγ production following ex vivo antigen stimulation. More CD8 T cells infiltrated and were activated after PD-L1 mAb treatment in mice with immunogenic MOC1 tumors, which were stable or increased by the addition of rapamycin, but suppressed when PD901 was added. Rapamycin increased IFNγ production capacity in peripheral and tumor-infiltrating CD8 T cells. In vivo antibody depletion revealed a CD8 T-cell-dependent, and not NK cell-dependent mechanism of tumor growth inhibition after treatment with rapamycin and PD-L1 mAb, ruling out significant effects from NK cell-mediated antibody-dependent cellular cytotoxicity. Rapamycin also enhanced IFNγ or PD-L1 mAb treatment-associated induction of MHC class I expression on MOC1 tumor cells, an effect abrogated by depleting infiltrating CD8 T cells from the tumor microenvironment. These data conflict with traditional views of rapamycin as a universal immunosuppressant, and when combined with evidence of enhanced antitumor activity with the combination of rapamycin and PD-L1 mAb, suggest that this treatment combination deserves careful evaluation in the clinical setting. Cancer Immunol Res; 4(7); 611-20. ©2016 AACR.
Digital Distance Functions on a Honeycomb Point Lattice (2010)

A family of path-based distance functions, weighted distances based on neigh-borhood sequences, are deﬁned on the point lattice in which each Voronoi region (voxel) is a hexagonal prism of arbitrar ...
Memory bus encoding for low power: a tutorial (2002)

This paper contains a tutorial on bus-encoding techniques that target low power dissipation. Three general classes of codes, i.e., algebraic, permutation-based, and probability-based, are reviewed. A new mathematical framework for unifying the power-aware algebraic coding techniques based on the notion of leader sets is also presented.
Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging (2017)

ABSTRACT Mosquito blood cells are ancestral immune cells that help control infection by vector-borne pathogens. Despite their importance, little is known about mosquito blood cell biology beyond the ambiguous morphological and functional criteria used for their classification. Here we combined the power of single-cell RNA-sequencing, imaging flow cytometry and single-molecule RNA hybridization to analyze blood cells of the malaria mosquito Anopheles gambiae . By demonstrating that blood cells express nearly half of the mosquito transcriptome, our dataset represents an unprecedented view into their transcriptional machinery. Analyses of differentially expressed genes identified transcriptional signatures of two distinct cell types that challenge the current morphology-based classification of these cells. We further demonstrated an active transfer of a cellular marker between blood cells that confounds their identity. We propose that cell-to-cell exchange is broadly relevant for cell type classification and may account for the remarkable cellular diversity observed in nature.
Underwater Explosive Welding, Discussion Based on Weldable Window (2006)

A new method of underwater explosive welding is introduced and its possibilities are suggested. In the underwater explosive welding, a high explosive with detonation velocity of 7km/s is placed at an initial inclined angle to decrease the horizontal collision point velocity, which is one of the important parameters to achieve welding. This method is effective to accelerate a thin metal plate rapidly. However, this arrangement makes a difference in the welding conditions with horizontal position when a constant thickness explosive is used, as the propagation distance of the underwater shock wave increases at the ends. Hence, a method of linearly increasing the thickness of explosive in proportion to the propagation distance is proposed. This investigation intends to clarify the welding conditions in using a constant thickness explosive and linearly increasing thickness explosive based on numerical analysis. Further, a method of designing the assembly is confirmed through numerical analysis and its validity with the experimental results is demonstrated based on the welding window.
Crossover from Spin Accumulation into Interface States to Spin Injection in the Germanium Conduction Band (2012)

Electrical spin injection into semiconductors paves the way for exploring new phenomena in the area of spin physics and new generations of spintronic devices. However the exact role of interface states in the spin injection mechanism from a magnetic tunnel junction into a semiconductor is still under debate. In this Letter, we demonstrate a clear transition from spin accumulation into interface states to spin injection in the conduction band of n-Ge. We observe spin signal amplification at low temperature due to spin accumulation into interface states followed by a clear transition towards spin injection in the conduction band from 200 K up to room temperature. In this regime, the spin signal is reduced to a value compatible with the spin diffusion model. More interestingly, the observation in this regime of inverse spin Hall effect in germanium generated by spin pumping and the modulation of the spin signal by a gate voltage clearly demonstrate spin accumulation in the germanium conduction band.
Effect of urokinase on fibrinolysis and fibrinogenolysis. (1982)

The thrombolytic (fibrinolytic) effect of the urinary plasminogen activator, urokinase (UK), was compared with its fibrinogenolytic effect, using an artificial circulating system, and in in vivo pulmonary embolus and femoral vein thrombosis models. The thrombus lysing efficiency (fibrinolysis/fibrinogenolysis) was, in all cases, below 1.00, indicating that fibrinogenolysis is a primary function of UK while fibrinolysis is a secondary one.