gebhart/patrepeval huggingface dataset:
Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location. (1980)

The distribution of nerve growth factor (NGF) in rat pheochromocytoma cells (clone PC12) has been studied with two different techniques: immunofluorescence and autoradiography. It was found that NGF is progressively internalized in the cytoplasmic compartment and eventually accumulates in the form of discrete dots around the nucleus. A fraction of the internalized NGF appears within the nucleoplasm, often contiguous with the nucleolus. It is suggested that cytoplasmic and perinuclear NGF may be be in contact with a pool of tubulin or actin-like proteins in their soluble or organized form and play a key role in the process of arrest of division and neurite growth.
Differential Diagnosis of Solitary Breast Mass by MR Imaging, According to BI-RADS MRI and Lesion Size. (2015)

Poster: ECR 2015 / C-1794 / Differential Diagnosis of Solitary Breast Mass by MR Imaging, According to BI-RADS MRI and Lesion Size. by: Kawai, M. Kataoka, S. Kanao, M. Iima, N. Onishi, A. Ohashi, K. Togashi; Kyoto/JP
Direct biomechanical modeling of trabecular bone using a nonlinear manifold-based volumetric representation (2017)

Osteoporosis is associated with increased fracture risk. Recent advancement in the area of <i>in vivo</i> imaging allows segmentation of trabecular bone (TB) microstructures, which is a known key determinant of bone strength and fracture risk. An accurate biomechanical modelling of TB micro-architecture provides a comprehensive summary measure of bone strength and fracture risk. In this paper, a new direct TB biomechanical modelling method using nonlinear manifold-based volumetric reconstruction of trabecular network is presented. It is accomplished in two sequential modules. The first module reconstructs a nonlinear manifold-based volumetric representation of TB networks from three-dimensional digital images. Specifically, it starts with the fuzzy digital segmentation of a TB network, and computes its surface and curve skeletons. An individual trabecula is identified as a topological segment in the curve skeleton. Using geometric analysis, smoothing and optimization techniques, the algorithm generates smooth, curved, and continuous representations of individual trabeculae glued at their junctions. Also, the method generates a geometrically consistent TB volume at junctions. In the second module, a direct computational biomechanical stress-strain analysis is applied on the reconstructed TB volume to predict mechanical measures. The accuracy of the method was examined using micro-CT imaging of cadaveric distal tibia specimens (N = 12). A high linear correlation (r = 0.95) between TB volume computed using the new manifold-modelling algorithm and that directly derived from the voxel-based micro-CT images was observed. Young’s modulus (YM) was computed using direct mechanical analysis on the TB manifold-model over a cubical volume of interest (VOI), and its correlation with the YM, computed using micro-CT based conventional finite-element analysis over the same VOI, was examined. A moderate linear correlation (r = 0.77) was observed between the two YM measures. This preliminary results show the accuracy of the new nonlinear manifold modelling algorithm for TB, and demonstrate the feasibility of a new direct mechanical strain-strain analysis on a nonlinear manifold model of a highly complex biological structure.
Sedimentologie de la matiere organique dans les formations du Mesozoique de l'Atlantique Nord (1982)

Other| January 01, 1982 Sedimentologie de la matiere organique dans les formations du Mesozoique de l'Atlantique Nord J. P. Herbin; J. P. Herbin Author Inst. francais petrole, Rueil-Malmaison 92500, France Search for other works by this author on: GSW Google Scholar G. Deroo G. Deroo Author Search for other works by this author on: GSW Google Scholar Bulletin de la Société Géologique de France (1982) S7-XXIV (3): 497–510. https://doi.org/10.2113/gssgfbull.S7-XXIV.3.497 Article history first online: 03 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation J. P. Herbin, G. Deroo; Sedimentologie de la matiere organique dans les formations du Mesozoique de l'Atlantique Nord. Bulletin de la Société Géologique de France 1982;; S7-XXIV (3): 497–510. doi: https://doi.org/10.2113/gssgfbull.S7-XXIV.3.497 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyBulletin de la Société Géologique de France Search Advanced Search This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001‐2007) (2009)

Despite the widespread use of antifungal prophylaxis and the introduction of new antifungal agents, the incidence and associated mortality rates of candidemia remained stable in high-risk hematologic malignancy patients. However, its epidemiological characteristics have shifted, with C. parapsilosis and C. tropicalis becoming more common.
Mechanisms of Cytochrome P450‐Mediated Reactions (2012)

Abstract Cytochrome P450 (P450) oxidations are the most common reactions involved in the metabolism of drugs. P450 oxidations consist of two phases, oxygen activation and substrate oxidation. The latter phase has a general inherent chemistry. However, owing to rearrangements during and after oxidation, the reactions catalyze diverse processes including carbon hydroxylation, heteroatom oxygenation and dealkylation, epoxidation, and a variety of other transformations. The course of reactions is considered not to be due to inherent chemistry associated with individual P450s but due to the juxtaposition of substrates within active sites.
Seven big ideas in robotics, and how to teach them (2012)

Robotics is widely recognized as an interdisciplinary mixture of engineering and computer science, but the latter component is not well represented at many undergraduate institutions. The sophisticated technologies that underlie perception, planning, and control mechanisms in modern robots need to be made accessible to more computer science undergraduates. Following the curriculum design principles of Wiggins and McTighe (Understanding by Design, 2nd Ed.), I present seven big ideas in robotics that can fit together in a one semester undergraduate course. Each is introduced with an essential question, such as "How do robots see the world?" The answers expose students to deep concepts in computer science in a context where they can be immediately demonstrated. Hands-on labs using the Tekkotsu open source software framework and robots costing under $1,000 facilitate mastery of these important ideas. Courses based on parts of an early version of this curriculum are being offered at Carnegie Mellon and several other universities.
Membrane processes in myotonic dystrophy duringin vitroaging of erythrocytes (1982)

The present communication is devoted to investigating the possibility that in myotonic dystrophy (MyD) a decreased ATP utilization by the membrane may produce modifications in glycoprotein structure and/or in the supramolecular arrangement of some membrane proteins. The study was carried out a) by determining the membrane sialic acid content and the cellular ATP concentration in 10 cases of MyD, b) by evaluating the structural modifications of membrane glycoproteins occurring during in vitro incubation, c) by testing the presence on the membrane of high molecular weight aggregates of proteins, and d) by evaluating the distribution of hydrophobic and hydrophilic domains of the membrane by using 1-anilino-8-naphthalene sulfonate (1,8 ANS) as a fluorescent probe. Our evidence suggests that the ATP concentration and membrane sialic acid content are within normal values. Only in two cases did structural modifications of membrane glycoproteins occur while the supramolecular assembly of membrane proteins could be considered normal. The fluorescent probe behaviour after in vitro aging was indicative of a decreased polarity of its environment.
Sodium Borohydride Assisted Hydrogen Peroxide Bleaching Process for Mechanical Pulps (2004)

Sodium borohydride can assist in improving the performance of peroxide bleaching of mechanical pulps. In this paper, we report the PR process, in which a small amount of sodium borohydride, along with sodium silicate is added to the pulp for a pretreatment, followed by the addition of hydrogen peroxide. It has been demonstrated that the PR process gives significantly higher brightness than the conventional peroxide process under otherwise the same conditions. The PR process is of particular interest for mills to produce mechanical pulps of very high brightness.
Is accuracy of serum free light chain measurement achievable? (2015)

The serum free light chain (FLC) assay has proven to be an important complementary test in the management of patients with monoclonal gammopathies. The serum FLC assay has value for patients with plasma cell disorders in the context of screening and diagnosis, prognostic stratification, and quantitative monitoring. Nonetheless, serum FLC measurements have analytical limitations which give rise to differences in FLC reporting depending on which FLC assay and analytical platform is used. As the FLC measurements are incorporated in the International Myeloma Working Group guidelines for the evaluation and management of plasma cell dyscrasias, this may directly affect clinical decisions. As new certified methods for serum FLC assays emerge, the need to harmonise patient FLC results becomes increasingly important. In this opinion paper we provide an overview of the current lack of accuracy and harmonisation in serum FLC measurements. The clinical consequence of non-harmonized FLC measurements is that an individual patient may or may not meet certain diagnostic, prognostic, or response criteria, depending on which FLC assay and platform is used. We further discuss whether standardisation of serum FLC measurements is feasible and provide an overview of the steps needed to be taken towards harmonisation of FLC measurements.
Quantifying responsiveness of TCP aggregates by using direct sequence spread spectrum CDMA and its application in congestion control (2005)

In this paper, we introduce the notion of responsiveness for TCP aggregates and define it as the degree to which a TCP aggregate reduces its sending rate to the network as a response to packet drops. We define metrics that describe the responsiveness of TCP aggregates, and then we suggest two methods for determining the values of these quantities. The first method is based on a test in which we drop a few packets from the aggregate intentionally and measure the resulting rate decrease of that aggregate. This kind of test is not robust to multiple simultaneous tests performed at different routers. Extensions are done to make the test robust to multiple simultaneous tests by using ideas from the CDMA approach to multiple access channels in communication theory. Then we use these methods to perform congestion control. A distinguishing feature of our congestion control scheme is that it maintains a degree of fairness among different aggregates.
Ethylene-1-butene copolymers. 1. Comonomer sequence distribution (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEthylene-1-butene copolymers. 1. Comonomer sequence distributionEric T. Hsieh and J. C. RandallCite this: Macromolecules 1982, 15, 2, 353–360Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ma00230a030https://doi.org/10.1021/ma00230a030research-articleACS PublicationsRequest reuse permissionsArticle Views905Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A retrospective analysis of intramural NCI prostate cancer trials: Progress made and insights gleaned. (2010)

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One-step competitive immunochromatographic assay for semiquantitative determination of lipoprotein(a) in plasma (1993)

Numerous studies have associated high concentrations of lipoprotein(a) [Lp(a)] with atherosclerosis. We developed a rapid, one-step competitive immunochromatographic assay to measure Lp(a) in plasma. The assay is performed on a nitrocellulose membrane strip and the result is determined by a visual readout of rust-colored colloidal selenium. The assay is based on the principle that Lp(a) in the sample will compete with Lp(a)-coated colloidal selenium for binding to the anti-Lp(a) monoclonal antibody immobilized on the assay strip in the format of four ladder bars. The number of capture bars that appear as a result of the formation of colloidal selenium color is proportional to the concentration of the Lp(a) protein in the samples. The strip assay semiquantitatively measures Lp(a) concentrations ranging from 0 to 180 mg/L of Lp(a) protein in serum, plasma, or fingerstick whole-blood samples. This assay appears very useful for quick identification of individuals with above-normal concentrations of plasma Lp(a) protein (> 70 mg/L), and has potential for monitoring a patient's response to treatment with Lp(a)-lowering drugs.
The action of mould enzymes on sucrose (1953)

Reproducibility of the 8ubstrate. This has been investigated by carrying out, in triplicate, estimations of the activity of a duodenal juice using four different substrate preparations. The results given in Table Analysis shows that the variation between substrates is not significant (P >0-05).
Cooverexpression of alanine aminotransferase 1 in Chinese hamster ovary cells overexpressing taurine transporter further stimulates metabolism and enhances product yield (2013)

Innovation in monoclonal antibody (mAb) production continues to be driven by cell engineering strategies to increase yield and improve product quality. In a previous study, to investigate the effectiveness of transporter overexpression strategies, we prepared a taurine transporter-overexpressing host cell line (DXB11/TAUT) that produced a higher proportion of high-mAb-titer strains than did the parent host cell line. In the current study, we selected a single DXB11/TAUT/mAb1 strain that remained viable for longer (up to 1 month) under common fed-batch culture conditions, and the improvement in viability could be attributed to its improved metabolic properties. It was also more productive (up to >100 pg/cell/day) and yielded more mAb1 (up to 8.1 g/L/31 days) than the parent cell line, and the mAb1 it produced was of comparable quality. These results suggested that this host cell engineering strategy has unique potential for the improvement of mAb-producing Chinese hamster ovary (CHO) cells; for example, it may be appropriate for high cell density perfusion culture. TAUT-overexpressing cell lines rapidly accumulated the byproduct alanine, and our challenge in the present study was to apply a strategy for modulating cell metabolism to utilize this byproduct to achieve a high mAb yield in a shorter culture period. To accomplish this, we genetically modified the DXB11/TAUT/mAb1 strain to cooverexpress alanine aminotransferase 1 (ALT1). The resulting DXB11/TAUT/mAb1/ALT1 cooverexpressing strain gave a higher mAb yield in a shorter culture period (5.9 g/L/14 days). It is usually difficult to drive the overexpression of two functional genes while balancing competing goals. However, forced cooverexpression of TAUT and ALT1 in our DXB11/TAUT/mAb1/ALT1 strain resulted in a higher proliferation than the DXB11/TAUT/mAb1 strain, with an ideal balance between cell viability and productivity. Therefore, we have demonstrated a strategy capable of achieving an optimum balance among the goals of cell viability, productivity, and proliferative capacity.
Novel Non-nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 5. 4-Substituted and 2,4-Disubstituted Analogs of Nevirapine (1995)

Molecular modeling analysis of the recently published X-ray crystal structure of nevirapine bound to wild type human immunodeficiency virus type 1 reverse transcriptase (WT-RT) indicated the presence of a lipophilic cavity proximal to the 4-position of the inhibitor. A series of 4-substituted derivatives of nevirapine were thus synthesized to assess structure-activity relationships (SARs) and to see if increased binding to this region might translate into greater activity against mutant RTs. The results show that compounds with an appropriately spaced aryl ring appended to the 4-position of the dipyridodiazepinone ring system show good activity against WT-RT. Furthermore certain derivatives appear to inhibit the Y181C mutant RT. Attempts to combine these results with the recent discovery that 2-substituents enhance activity against the Y181C mutant led to a few compounds with moderate activity against both enzymes. The SAR of these two positions, however, could not be combined in a simple fashion.
HDAC1‐mSin3a‐NCOR1, Dnmt3b‐HDAC1‐Egr1 and Dnmt1‐PCNA‐UHRF1‐G9a regulate the NY‐ESO1 gene expression (2012)

The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies. Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated. In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes. Thus, our data illustrate the orchestration of a sequential epigenetic mechanism including the histone deacetylation and methylation, and the DNA methylation processes.
Integrated Remediation Of Brownfield Sites Using Batch And Continuous Thermal Desorption Combined With Physiochemical Processes (2002)

The use of an integrated approach to manage environmental cleanups, based on the use of thermal resorption and other processes, is ideally suited for the management of brownfield sites. Processing of sludge, sediment, and contaminated soil using continuous indirect thermal resorption based on a vertical retort achieves the desired cleanup levels for contaminants such as organic compounds, pesticides, and PCB. This process when connected to a high-temperature ceramic filtration unit and a full-condensing gas treatment train, in combination with destruction processes such as plasma destruction or recycling processes for organic compounds, offer a range of resources that, when used in an integrated way, can deliver the desired results whilst minimizing environmental and health risks and achieving a one stop solution. The effectiveness of this system is supported by data from industrial-scale applications of the processes in the treatment of PCB-contaminated soil and tetrachloroethylene-contaminated material.
Nanoscale Engineering of Polymorphism in Cu2Se-Based Composites (2020)

Crystal polymorphism selection during synthesis is extremely challenging. However, promoting the formation of a specific metastable polymorph enables modulation of the functional properties of phase-change materials through alteration of the relative abundance of various polymorphs. Here, we demonstrate the stabilization of the superionic β-Cu<sub>2</sub>Se phase under ambient conditions and the direct control over the relative ratio between the α-Cu<sub>2</sub>Se and β-Cu<sub>2</sub>Se polymorphs in (<i>x</i>)CuGaSe<sub>2</sub>/(1-<i>x</i>)Cu<sub>2</sub>Se composites using CuGaSe<sub>2</sub> nanoseeds. We found that the small lattice mismatch between β-Cu<sub>2</sub>Se (cubic) and the <i>ab</i> plane of tetragonal CuGaSe<sub>2</sub> nanoseeds promotes the formation of low-energy coherent CuGaSe<sub>2</sub>/β-Cu<sub>2</sub>Se interfaces, leading to preferential stabilization of β-Cu<sub>2</sub>Se. Astonishingly, the hierarchical microstructure of the resulting composites enables a remarkable decoupling of charge and heat transport, which is manifested by a breakdown of the Wiedemann-Franz law.
Flexible and cost-effective optical metro network with photonic-sub-lambda aggregation capability (2016)

This paper presents a cost-effective optical metro network called “Photonic Sub-Lambda transport network” suitable for low-loaded rural areas, and presents the results of network cost evaluation and experimental demonstration of photonic-sub-lambda aggregation.
Flexible Charge Balanced Stimulator With 5.6 fC Accuracy for 140 nC Injections (2012)

Electrical stimulations of neuronal structures must ensure net injected charges to be zero for biological safety and voltage compliance reasons. We present a novel architecture of general purpose biphasic constant current stimulator that exhibits less than 5.6 fC error while injecting 140 nC charges using 1.4 mA currents. The floating current sources and conveyor switch based system can operate in monopolar or bipolar modes. Anodic-first or cathodic-first pulses with optional inter-phase delays have been demonstrated with zero quiescent current requirements at the analog front-end. The architecture eliminates blocking capacitors, electrode shorting and complex feedbacks. Bench-top and in-vivo measurement results have been presented with emulated electrode impedances (resistor-capacitor network), Ag-AgCl electrodes in saline and in-vivo (acute) peripheral nerve stimulations in anesthetized rats.