gebhart/patrepeval huggingface dataset:
Bacterial infections in coagulating blood: calcium inhibits complement alternative pathway (2003)

Bacterial survival in coagulated blood can cause complications associated with endocarditis or biomaterial infections. We report that during recalcification of diluted (1:5) citrated human whole blood, the killing activity toward E. coli decreased 90-fold after the addition of thrombin (1 U/ml) and CaCl/sub 2/ (50 mM). The killing activity in diluted citrated whole blood or plasma was Mg/sup 2+/-dependent and Ca/sup 2+/-independent (as well as heat-inactivated in plasma), demonstrating complement alternative pathway mediation of E. Coli lysis. Addition of calcium from 0 to 10 mM CaCl/sub 2/ in the presence of heparin (5 U/ml), PPACK (250 /spl mu/M), or hirudin (33 U/ml) to diluted citrated whole blood or plasma caused a dose-dependent inhibition of bacterial killing. Excess addition of fibrin or fibrinogen had no effect on bacterial survival in whole blood or plasma, with or without coagulation. Physiological levels of Ca/sup 2+/ (1 mM) had a cytoprotective effect that attenuated alternative pathway killing of E. coli. This previously unrecognized calcium modulation of the alternative pathway killing must be considered in the study of bacterial survival in coagulating blood.
INACTIVATION OF A ROTAVIRUS BY DISINFECTANTS (1981)

Rotavirus SA 11, clarified and in human faeces, was exposed to eight commonly used hospital and laboratory disinfectants for periods between 15 seconds and two hours. Of the three hard disinfectants tested, 0.95 by volume (95% v/v) ethanol and 0.05 by volume (5% v/v) Biogram were more effective in inactivating SA 11 than 4% (w/v) or 10% (w/v) formaldehyde, with 0.95 by volume ethanol being the most effective of all of the disinfectants tested. None of the skin disinfectants tested, Betadine, Hexol, Hibiclens and Hibitane in alcohol, were very effective against the rotavirus in the presence of faeces, although Hexol and Hibitane in alcohol inactivated clarified SA 11 fairly quickly. Because of its rapidity of action against SA 11, even in the presence of faeces, and relatively non-deleterious effect on the skin, 0.95 by volume ethanol may be more useful as a handwash than these skin preparations. Undiluted Milton Antibacterial Solution gave very variable results, while the same solution diluted 1 in 80 had little effect on clarified SA 11.
Response of Dendroctonus brevicomis to different release rates of nonhost angiosperm volatiles and verbenone in trapping and tree protection studies (2008)

Abstract A blend of eight nonhost angiosperm volatiles (benzyl alcohol, benzaldehyde, guaiacol, nonanal, salicylaldehyde, ( E )‐2‐hexenal, ( E )‐2‐hexen‐1‐ol and ( Z )‐2‐hexen‐1‐ol) without [NAV] and with [NAVV] (–)‐verbenone (4,6,6‐trimethylbicyclo[3.1.1]hept‐3‐en‐2‐one) were tested at low (L), medium (M) and high (H) release rates for their ability to reduce attraction of western pine beetle, Dendroctonus brevicomis LeConte, to attractant‐baited ( exo ‐brevicomin [racemic, 3 mg/d], frontalin [racemic, 3 mg/d] and myrcene [18 mg/d]) multiple funnel traps. NAV‐L (40 mg/d) had no significant effect. Verbenone alone (50 mg/d) and NAV‐M (240 mg/d) both significantly reduced attraction, but no significant difference was observed between the two treatment means. NAV‐H (430 mg/d) significantly reduced catches by ∼60% and 78% compared to verbenone alone and the baited control, respectively. In a second experiment, combining (–)‐verbenone with NAV (NAVV) increased the effects observed in Experiment 1. NAVV‐M (240 mg/d) resulted in an ∼69% and 83% reduction in trap catch compared to verbenone alone and the baited control, respectively. Significantly fewer D . brevicomis were captured in NAVV‐H (430 mg/d) than any other treatment resulting in an ∼93% reduction in trap catch compared to the baited control. In a third experiment, NAVV was tested at three release rates for its ability to protect individual ponderosa pines, Pinus ponderosa Dougl. ex Laws., from attack by D . brevicomis . Cumulative release rates varied in direct proportion to tree diameter, but represented quarter, half and full NAVV rates. NAVV significantly reduced the density of D . brevicomis attacks, D . brevicomis successful attacks, and levels of tree mortality on attractant‐baited trees. Only three of 15 NAVV‐treated trees died from D . brevicomis attack while ∼93% mortality (14/15) was observed in the untreated, baited control. Quarter and half rates were ineffective for reducing tree mortality.
Development of novel carbon nanotube reinforced magnesium nanocomposites using the powder metallurgy technique (2005)

10.1088/0957-4484/17/1/002
Optimization of Resource Allocation and User Association for Energy Efficiency in Future Wireless Networks (2017)

The user requirements in the future wireless networks are heterogeneous. The resource allocation and user association are crucial factors to meet user requirements and save energy. In this paper, the optimization of resource allocation and user association problem in both low data and high data requirement scenario is studied. In the low data requirement scenario, a network energy consumption minimization problem which considering the signal-to-interference-plus-noise ratio coverage constraints and jointly determines the optimal density of micro base stations (mBSs) and the optimal association bias is formulated. The closed-form solution of the optimal mBSs density and association bias is derived, O(λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-(α/2)</sup> ) u respectively. Optimal association bias grows like O(λ ) as a function of user density λu (α is path loss factor) and the optimal density of mBSs is a linearly monotone increasing function of the user density. In the high data requirement scenario, a rate coverage maximization problem by adjusting the bandwidth allocation and user association are investigated. The relationship between bandwidth allocation and user association bias is obtained and a dynamic gradient iterative algorithm is used to solve the maximization problem. Simulation results verify the relevant derivations and demonstrate the user density and requirement have an important influence on the optimal resource allocation and optimal association bias.
Voltammetric Soft Modelling Approach for Systems with Both Electrochemically Labile and Inert Complexes: the Zn-Glycine Case (2001)

A multivariate curve resolution method using alternating least squares (MCR-ALS) has been applied to the study of the Zn-glycine system by polarographic techniques. The electroanalytical behavior of this system does not allow the direct application of hard modelling methods, and makes it an ideal model system to be studied by soft modelling methods. Although the condition of linearity of the current data with respect to the concentrations is not totally fulfilled, the obtained results suggest that the system is reasonably well explained considering the formation of three successive complexes, the two first ones being electrochemically labile and the third one being inert. A satisfactory resolution was achieved if during the ALS optimization the unimodality constraint was only applied to some signals (those corresponding to the free metal ion and to the first two complexes), based on the observed morphology of the experimental voltammograms. Stability constants of these complexes have been estimated from the concentration profiles obtained in the ALS optimization. They have been satisfactorily compared with stability constants from the literature, suggesting that soft modelling provides good estimations of the complexation parameters, and that it is a very useful tool for cases where hard modelling can not be applied.
WTC deafness Kyoto (dfk): a rat model for extensive investigations ofKcnq1functions (2005)

KCNQ1 forms K+ channels by assembly with regulatory subunit KCNE proteins and plays a key role in the K+ homeostasis in a variety of tissues. In the heart, KCNQ1 is coassembled with KCNE1 to produce a cardiac delayed rectifier K+ current. In the inner ear, the KCNQ1/KCNE1 complex maintains the high concentration of K+ in the endolymph. In the stomach, KCNQ1 is coassembled with KCNE2 to form the K+ exflux channel that is essential for gastric acid secretion. In the colon and small intestine, KCNQ1 is coassembled with KCNE3 to play an important role in transepithelial cAMP-stimulated Cl- secretion. For further understanding of Kcnq1 function in vivo, an animal model has been required. Here we reported the identification of a coisogenic Kcnq1 mutant rat, named deafness Kyoto (dfk), and the characterization of its phenotypes. WTC-dfk rats carried intragenic deletion at the Kcnq1 gene and showed impaired gain of weight, deafness, and imbalance resulting from the marked reduction of endolymph, prolonged QT interval in the electrocardiogram (ECG), and gastric achlorhydria associated with hypertrophic gastric mucosa. Surprisingly, WTC-dfk rats showed hypertension, which suggested that Kcnq1 might be involved in the regulation of blood pressure. These findings suggest that WTC-dfk rats could represent a powerful tool for studying the physiological functions of KCNQ1 and for the establishment of new therapeutic procedures for Kcnq1-related diseases.
A study of free radicals in irradiated/aged UHMWPE materials (2002)

UHMWPE bar stock, resin powder and fibers that were irradiated with an electron beam and then stored in air for three years were investigated for long-lived free radicals. Significant concentrations of free radicals were found in all UHMWPE materials. Peroxy radicals are predominant in the UHMWPE materials that are highly accessible to oxygen, while more primary radicals remain in the UHMWPE materials that are isolated from oxygen. Based on this study, it is expected that irradiation of UHMWPE in an inert environment would result in long-lived primary radicals, which could be a potential cause of long-term oxidation. Furthermore, a highly crystalline UHMWPE may be more susceptible to long-term oxidation as more free radicals can be trapped in crystalline regions.
Improving Representation of Snow on Sea Ice in Climate Models (2015)

Snow on Sea Ice Workshop; Barrow, Alaska, 29 April to 1 May 2015
ChemInform Abstract: First Inverse Electron‐Demand Diels—Alder Methodology of 3‐Chloroindoles and Methyl Coumalate to Carbazoles. (2014)

Abstract The first example of the use of substituted indoles as dienophiles in title reaction with 2‐pyrone under solely thermal conditions is presented.
The Role of Capecitabine in First-Line Treatment for Patients with Metastatic Breast Cancer (2006)

Capecitabine is an important drug in the therapeutic armamentarium for metastatic breast cancer. A comprehensive worldwide clinical trial program involving >10,000 patients with locally advanced and metastatic breast cancer has provided evidence for the current treatment strategies. On the basis of data demonstrating consistent activity across several trials in patients with heavily pretreated breast cancer, capecitabine was approved in the U.S. in 1998 for the treatment of patients with metastatic disease resistant to paclitaxel and anthracycline-containing therapy, with later European Union approval for single-agent capecitabine in the metastatic setting. Capecitabine plus docetaxel (XT) was approved by the U.S. Food and Drug Administration for the treatment of metastatic breast cancer in 2001 on the basis of the large phase III trial comparing XT with docetaxel alone, which showed a survival advantage for combination therapy compared with single-agent therapy. This was shortly followed by European approval for the combination in metastatic breast cancer. The clinical utility of capecitabine in the management of breast cancer is supported by its convenient oral dosing schedule and favorable safety profile, as well as its excellent clinical activity in primary and metastatic breast cancer. Recently, clinical trials have studied single-agent capecitabine as first-line treatment and evaluated other capecitabine-containing combinations with cytotoxic and novel targeted agents.
Transformation Products of Hazardous Cyanobacterial Metabolites in Water (2014)

Cyanobacteria are often grouped into primary and secondary metabolites, wherein the former are essential for growth, development and reproduction of the organism while the latter are indirectly involved in the organisms' survival but their absence does not result in immediate death of the organism. These secondary metabolites are the main focus of this chapter. Cyanobacteria secondary metabolites, whether constitutive or induced, play a key role in their interactions with the environment. Some of these metabolites include taste and odor compounds such as geosmin (GSM) and 2-methylisoborneol (MIB), anti-microbials, terpenoids, lactones, metal chelators, protease inhibitors, indole alkaloids and potent toxins, frequently called cyanobacterial toxins or cyanotoxins (produced by cyanobacteria commonly found in surface water supplies), known to affect a wide range of living organisms. The chapter reviews some of the hazardous secondary metabolites produced by cyanobacteria and their potential transformation products (TPs) formed during various transformation processes.
Magnetic images capable of multicolor developement (1982)

In this paper, some new ways to achieve single-pass color magnetic printing are explored both theoratically and experimentally. The basic requirement here is to put all the constraints on the print engine itself and none -- except the color -- on the toner particles. More precisely, the main features, common to all the described methods, are : (1) color-coded single latent magnetic image, (2) toners of same physical characteristics except color, (3) advantages of perpendicular recording on a drum-based magnetographic engine. The image parameters used for color coding are described. Single parameter coding is first analysed. Then redundant coding on two parameters with additional specific advantages is presented. The main justifications are based on previous work on magnetographic development, but early experimental results are also shown and discussed.
Abstract 064: 20-HETE Contributes to Vasoconstriction of Renal Microvessels and Sodium Retention in Cyp4a14-/- Mice, a Model of 20-HETE Dependent Hypertension (2015)

20-HETE (20-Hydroxyeicosatetraenoic acid), is a cytochrome P450 (CYP) 4A-derived arachidonic acid metabolite. 20-HETE has been linked to both pro-hypertensive (via increased vasoconstriction, vascular remodeling and vascular injury of renal microvessels) and anti-hypertensive (inhibiting ion transport in the distal nephron) functions. In this study we examined the effect of 20-SOLA (2,5,8,11,14,17-hexaoxanonadecan-19-yl-20-hydroxyeicosa-6(Z),15(Z)-dienoate), a water soluble antagonist of the actions of 20-HETE on renal hemodynamics and sodium (Na) excretion in Cyp4a14 knockout (CYP4a14-/-) male mice. The CYP4a14-/- male mice display hypertension accompanied by increased vascular 20-HETE levels. Administration of 20-SOLA (10mg/kg/day in drinking water) normalized blood pressure (BP) in male Cyp4a14-/- mice at day 10 of treatment (124±1 vs. 153±2 mmHg in untreated male Cyp4a14-/- mice; p&lt;0.05). The normalization of blood pressure was accompanied by transient increase in the urinary sodium excretion in the Cyp4a14-/- male mice (8.3±0.7 vs. 5.8±0.5 μmol/g body weight/day; p&lt;0.05). Importantly, 20-SOLA increased glomerular filtration rate (GFR) of Cyp4a14-/- mice (2.38±0.05 vs. 1.88±0.18 μL/min/mg kidney weight, p&lt;0.05) as opposed to no changes observed in the wild type (WT: (2.26±0.18 vs. 2.33±0.20μL/min/mg kidney weight). Evaluation of the renal blood flow (RBF) by laser Doppler flowmetry showed that treatment with 20-SOLA increased the RBF in Cyp4a14-/- mice by 12.3±4%, which remained unaltered in the WT. Additionally, the pressure-induced myogenic tone of isolated preglomerular microvessels was significantly elevated in Cyp4a14-/- mice; 20-SOLA treatment prevented the increase in myogenic responses. The natriuretic response to an isotonic saline loading challenge (10% of body weight, IP) was significantly attenuated in the Cyp4a14-/- mice as compared to the WT (35.5±2.8 vs. 57.4±8.3 percentage of Na load, p&lt;0.05); this was corrected by 20-SOLA (61.7±5.7 percentage of Na load, p&lt;0.05). These results confirm that 20-SOLA normalizes blood pressure of Cyp4a14-/- male mice and demonstrates that this is associated with increases in GFR, RBF and natriuresis.
Soil and Foliar Application of Magnesium Compounds for the Control of Magnesium Deficiency in ‘Shamouti’ Orange Trees (1984)

Abstract Band application of MgCl 2 ·6H 2 O under the tree canopy of ‘Shamouti’ orange [ Citrus sinensis (L.) Osbeck] trees significantly increased leaf Mg and Cl concentration. MgSO 4 and MgO were not effective. Fertigation with MgCl 2 ·6H 2 O was less efficient than band application and was not superior to foliar application of Mg(NO 3 ) 2 ·6H 2 O for increasing leaf Mg concentrations. In spite of high Cl concentration of the leaves, no visible toxicity symptoms were observed.
Evolution des effets non intentionnels de la lutte chimique contre le campagnol terrestre sur la faune sauvage et domestique (2014)

Times Cited: 0
INFLUENCE OF ISLET TRANSPORTATION ON PANCREATIC ISLET ALLOTRANSPLANTATION IN TYPE 1 DIABETIC PATIENTS WITHIN THE SWISS-FRENCH GRAGIL NETWORK (2004)

ITT does not seem to influence the efficiency of pancreatic islet allotransplantation in type 1 diabetic patients. These results emphasize the scope for multicenter networks such as the GRAGIL group.
Effect of warming on the carbon flux of the alpine wetland on the Qinghai–Tibet Plateau (2022)

Under the scenario of global warming, the response of greenhouse gas emissions from alpine wetlands remains unclear. In this study, fluxes of CO 2 and CH 4 were measured during daytime for the microtopographic features of hollows and hummocks in a wetland in the Tibetan Plateau under two elevated temperatures, increments of ∼1°C (T1 treatment) and ∼2°C (T2 treatment), during the growing season in 2019. The results showed that warming significantly increased the cumulative net ecosystem CO 2 exchanges (NEE) for both microtopographic features in the wetland compared to the control due to a combination of the increased gross primary production (GPP) with an increase in ecosystem respiration (ER). Similarly, warming also increased cumulative CH 4 emission significantly. The effect was stronger for T2 than that for T1 for all component fluxes (GPP, ER, NEE, and CH 4 ). Generally, NEE and CH 4 fluxes both rose at first and then decreased. NEE peaked at the end of July for both hollows and hummocks, while CH 4 emissions peaked in the middle of August. The cumulative CH 4 emissions from the hummocks were significantly higher than those of the hollows, and CH 4 emissions under illumination were significantly higher than those in darkness, which may be caused by the irradiation-sensitive vegetable internal convective gas transport system which diffuses CH 4 from the pedosphere. This study revealed that warming strengthened the function of the CO 2 sink but also increased CH 4 emissions from the alpine wetlands on the Qinghai–Tibet Plateau.
Preparation and Root Growth‐Inhibitory Activity of N‐Substituted 2‐(2‐Chloroacetamido)‐3‐(furan‐2‐yl)propanamides. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Inkjet-Printing-Derived Lead-Zirconate-Titanate-Based Thick Films for Printed Electronics (2020)

We have investigated the processing of lead-zirconate-titanate-based thick films by inkjet printing Pb (Zr0.53Ti0.47)0.98Nb0.02O3 with a 6 mol% excess of PbO nanosized powder dispersed in water. Different waveforms were employed to determine the optimum size and shape of the drops. A uniform, defect-free pattern with dimensions of 4 mm × 4 mm can be printed using 20 V and a drop spacing of 20 μm. The inkjet-printed films were heated to 400 °C to remove the organics and subsequently sintered at 750 and 850 °C. The correlations between the density, grain size and electromechanical properties of the thick films and bulk ceramics are qualitatively discussed. A thickness coupling factor of 46% was obtained for a 15-μm-thick film sintered at low temperature of 850 °C, which is comparable to the value of the bulk ceramic with an identical nominal chemical composition. Our results are important for the economic and environmental-benign printing of piezoelectric materials applicable in variety of electronic devices, such as sensors, actuators, transformers, piezoelectric energy harvesters and transducers.
Basic Study of Dielectric Properties of Cancer Cells by Dielectrophoretic Velocimetry (2021)

Cell separation technique is essential for the detection of circulating tumor cells in blood and for enrichment of stem cell in regenerative medicine. However, conventional methods require cell labeling such as antibodies, which may damage the cells during the operation. Therefore, dielectrophoresis (DEP), a "label-free" separation technique that eliminates the effects on cells, has been attracting attention. In this paper, we investigated the dielectric properties of Jurkat cells derived from human T-cell leukemia cells by dielectrophoretic velocimetry (DEPVM). An equivalent circuit model of the cell was constructed and the frequency characteristics of the voltage of each layer of the cell were calculated. As a result, it was shown that the live and dead cells showed opposite dielectrophoretic forces in the region below 10 kHz, indicating the possibility of separating them. The agreement between the theoretical calculations and the experimental results shows the validity of the equivalent circuit model.
Non-Oscillatory Pattern Learning for Non-Stationary Signals (2018)

This paper proposes a novel non-oscillatory pattern (NOP) learning scheme for several oscillatory data analysis problems including signal decomposition, super-resolution, and signal sub-sampling. To the best of our knowledge, the proposed NOP is the first algorithm for these problems with fully non-stationary oscillatory data with close and crossover frequencies, and general oscillatory patterns. NOP is capable of handling complicated situations while existing algorithms fail; even in simple cases, e.g., stationary cases with trigonometric patterns, numerical examples show that NOP admits competitive or better performance in terms of accuracy and robustness than several state-of-the-art algorithms.
Adaptive super-exponential algorithms for blind deconvolution of MIMO systems (2004)

Multichannel blind deconvolution of finite-impulse response (FIR) or infinite-impulse response (IIR) systems is investigated using the multichannel super-exponential method. First, some properties are shown for the rank of the correlation matrices relevant to the multichannel super-exponential method. Then, the matrix inversion lemma is extended to the degenerate rank case. Based on these results, two types of adaptive multichannel super-exponential algorithms are presented, that is, the one in covariance form and the other in QR-factorization form.