gebhart/patrepeval huggingface dataset:
INTRODUCTION AND DISCRETE-TIME MODELS (1997)

AbstractThe following sections are included:General and Historic Remarks : A Short SurveyMean-Variance Analysis in a One-Period Model: the Markowitz-ApproachMore on One-Period and Discrete-Time Approaches to Portfolio SelectionCriticisms and Limitations of Discrete-Time Models
Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data (2018)

Predictors of remission differed between MTX-naïve and prior MTX-exposed patients at entry. Latent class mixed models supported differential non-biological therapy response, with three distinct trajectories observed in both MTX-naïve and MTX-exposed patients. Findings should be useful when designing future RA trials and interpreting results of biomarker studies.
Colorado Potato Beetle and Potato Leafhopper Control with Foliar Sprays And Soil Applied Systematics, 1981 (1982)

Abstract Cut Norchip potatoes (size B) with 20 cm spacing on 1.5 m centers were machine-planted May 18. Treatment plots were single 7.6 m long rows replicated 5 times in a randomized complete block. Between each treatment row was a border row which received granular Temik (3.0 lbs ai/acre) in-furrow at planting. The border rows helped prevent movement of beetles between treatments. A 4.6 m alley separated the replicates. The soil type was silt loam with O.M. 2,3% and pH 6.5. The herbicides Eptam 7EC (4.0 lb ai/acre) and Sencor 50WP (1 lb ai/acre) were applied pre-emergence and post-emergence, respectively.
Embedded power electronics on the way to be launched (2015)

Embedded components technology has launched its implementation in volume products demanding for highest miniaturization level. Smart phones have been the enablers for this new technology using the capabilities of embedded components. All along the European project EmPower has been the enabler for the development of a new embedding technology for high power components like MOSFET, IGBT and power diodes and starting point for the industrialization for new power packages and power modules in AT&S. Technological challenges like the embedding of large dies require for new embedding concepts which consequently reduces thermal resistance and package inductance. CTE mismatch between large dies and the PCB construction required basic studies with new materials to enable the embedded power electronics in the kW range. All embedded semiconductors require copper terminations in order to be compatible for connecting with galvanic micro-vias. The back end processes at the semiconductor side are not prepared for this challenge, especially not for components with vertical current flow. This barrier was identified at the setup of EmPower and a double sided wafer plating equipment for galvanic deposition of copper is developed in the frame of the project.
Efficacy of minor analgesics in primary dysmenorrhoea: a systematic review (1998)

Naproxen, ibuprofen, mefenamic acid and aspirin are all effective in primary dysmenorrhoea. Ibuprofen appears to have the most favourable risk-benefit ratio. Acetaminophen appears to be less effective than nonsteroidal anti-inflammatory drugs, but there was only one trial meeting our inclusion criteria and further studies are required.
Pose estimation for category specific multiview object localization (2009)

We propose an approach to overcome the two main challenges of 3D multiview object detection and localization: The variation of object features due to changes in the viewpoint and the variation in the size and aspect ratio of the object. Our approach proceeds in three steps. Given an initial bounding box of fixed size, we first refine its aspect ratio and size. We can then predict the viewing angle, under the hypothesis that the bounding box actually contains an object instance. Finally, a classifier tuned to this particular viewpoint checks the existence of an instance. As a result, we can find the object instances and estimate their poses, without having to search over all window sizes and potential orientations. We train and evaluate our method on a new object database specifically tailored for this task, containing real-world objects imaged over a wide range of smoothly varying viewpoints and significant lighting changes. We show that the successive estimations of the bounding box and the viewpoint lead to better localization results.
Efficiently Combining Contour and Texture Cues for Object Recognition (2008)

This paper proposes an efficient fusion of contour and texture cues for image categorization and object detection. Our work confirms and strengthens recent results that combining complementary feature types improves performance. We obtain a similar improvement in accuracy and additionally an improvement in efficiency. We use a boosting algorithm to learn models that use contour and texture features. Our main contributions are (i) the use of dense generic texture features to complement contour fragments, and (ii) a simple feature selection mechanism that includes the computational costs of features in order to learn a run-time efficient model. Our evaluation on 17 challenging and varied object classes confirms that the synergy of the two feature types performs significantly better than either alone, and that computational efficiency is substantially improved using our feature selection mechanism. An investigation of the boosted features shows a fascinating emergent property: the absence of certain textures often contributes towards object detection. Comparison with recent work shows that performance is state of the art.
Ultrasound in Acute Stroke: Diagnosis, Reversed Robin Hood Syndrome and Sonothrombolysis (2011)

This chapter contains sections titled: Introduction Diagnosis of lesions amenable to intervention Reversed Robin Hood syndrome Other pathogenic mechanisms Monitoring thrombolytic therapy with ultrasound Ultrasound-enhanced thrombolysis Gaseous microspheres and sonolysis References
CANONICAL STRUCTURE OF LINEAR DYNAMICAL SYSTEMS (1962)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
The Synthesis and Alkaline Decomposition of γ-Aminopropylsulfuric Acid (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Alkaline Decomposition of γ-Aminopropylsulfuric AcidHarold W. Heine, Richard W. Greiner, Marjorie A. Boote, and Betsy A. BrownCite this: J. Am. Chem. Soc. 1953, 75, 10, 2505–2506Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01106a508https://doi.org/10.1021/ja01106a508research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis (2016)

Pulmonary fibrosis is a progressive and often fatal condition that is believed to be partially orchestrated by macrophages. Mechanisms that control migration of these cells into and within the lung remain undefined. We evaluated the contributions of the semaphorin receptor, plexin C1 (PLXNC1), and the exocytic calcium sensor, synaptotagmin 7 (Syt7), in these processes. We evaluated the role of PLXNC1 in macrophage migration by using Boyden chambers and scratch tests, characterized its contribution to experimentally induced lung fibrosis in mice, and defined the mechanism for our observations. Our findings reveal that relative to control participants, patients with idiopathic pulmonary fibrosis demonstrate excessive monocyte migration and underexpression of PLXNC1 in the lungs and circulation, a finding that is recapitulated in the setting of scleroderma-related interstitial lung disease. Relative to wild type, PLXNC1<sup>-/-</sup> mouse macrophages are excessively migratory, and PLXNC1<sup>-/-</sup> mice show exacerbated collagen accumulation in response to either inhaled bleomycin or inducible lung targeted TGF-β1 overexpression. These findings are ameliorated by replacement of PLXNC1 on bone marrow-derived cells or by genetic deletion of Syt7. These data demonstrate the previously unrecognized observation that PLXNC1 deficiency permits Syt7-mediated macrophage migration and enhances mammalian lung fibrosis.-Peng, X., Moore, M., Mathur, A., Zhou, Y., Sun, H., Gan, Y., Herazo-Maya, J. D., Kaminski, N., Hu, X., Pan, H., Ryu, C., Osafo-Addo, A., Homer, R. J., Feghali-Bostwick, C., Fares, W. H., Gulati, M., Hu, B., Lee, C.-G., Elias, J. A., Herzog, E. L. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.
A gate driver with output voltage equal to triple input voltage (2012)

This paper presents a gate driver, which has the output voltage with triple input voltage under only one positive-voltage source fed. Such a gate driver can reduce the number of voltage sources, and hence the size of the overall system is compact. From the point of view of power loss, this gate driver can reduce the transient period of the gate of the n-channel MOSFET power switch and hence decreases the switching loss, whereas such a gate driver can reduce the turn-on resistance of the n-channel MOSFET power switch and hence decreases the conduction loss. The detailed operating principles are illustrated and some simulated and experimental results are provided to verify the effectiveness of the proposed topology.
Ansätze zur Volumenbestimmung von Meningeomen in der PET/CT Bildgebung mit dem neuartigen Tracer F-18-SiTATE (2023)

Ziel/Aim F-18-SiTATE ist ein neuartiges F-18-markiertes, an Somatostatinrezeptoren bindendes Peptid. Dieses etablierte sich bisher in der Bildgebung von NET. Da oftmals ein alleiniges MRT die ossäre Infiltration eines Meningeoms nicht beurteilen kann, kann das F-18-SiTATE PET/CT (bisher: Ga-68 markierte Somatostatin Analoga) aufgrund der Bindungseigenschaften hierfür genutzt werden. Ziel war die Etablierung einer standardisierte Methode zur Volumenbestimmung von Meningeomen, die bis dato nicht existiert, jedoch für die Planung von OP und Radiatio von großer Relevanz ist.
Editorial: Frontiers in Chemistry-Rising Stars: Asia (2021)

EDITORIAL article Front. Chem., 24 November 2021 | https://doi.org/10.3389/fchem.2021.811459
Gelatin nanoparticles as gene carriers for transgenic chicken applications (2012)

To develop a safe and effective nonviral gene delivery system for transgenic chicken manipulation, we developed gelatin nanocarriers using a reporter plasmid (pEGFP-C1; enhanced green fluorescence protein, EGFP) that expressed EGFP. pEGFP-C1-containing gelatin nanoparticles (GP/pEGFP) were prepared using a water-ethanol solvent displacement method and characterized by size, surface charge, DNA loading, and DNA protection ability. For gene delivery, pEGFP-C1 was stably and efficiently encapsulated in GPs that were approximately 300 nm in diameter with a slight negative surface charge, which was prepared from gelatin solution at pH 8.0. Approximately, 85% of the plasmid DNA was encapsulated in the GPs. Electrophoresis results showed that the GPs provided protection against DNase I digestion. We used the GP/pEGFP as a vector to transfect cells and chicken embryos. The vector was nontoxic to cells, and GFP expression was effectively expressed 24 h after HeLa cell transfection. Direct injection was adapted for vector transport to the chicken embryo; injection in the area opaca (Ao) of the egg resulted in the highest hatching rate without affecting embryo development. GFP gene expression in embryo sections was observed 4 days after injection. The results of this study demonstrate that GPs are a suitable nonviral vector for delivering exogenous genes for transgenic chicken manipulation.
Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial (2008)

ACTRN12607000545460.
Communication Dynamics in Endogenous Social Networks (2010)

Erdos-Renyi graphs.
Overexpression of OsGF14f Enhances Quantitative Leaf Blast and Bacterial Blight Resistance in Rice (2022)

Although it is known that rice 14-3-3 family genes are involved in various defense responses, the functions of <i>OsGF14f</i> in response to diseases have not been reported. Here, we showed that the transcription of <i>OsGF14f</i> was significantly induced by leaf blast infection, and the overexpression of <i>Os</i><i>GF14f</i> quantitatively enhanced resistance to leaf blast and bacterial blight in rice. Further analysis showed that the expression levels of salicylic acid (SA) pathway-associated genes (<i>PAL1</i>, <i>NH1</i>, <i>PR1a</i> and <i>PR10</i>) in the <i>OsGF14f</i>-overexpressing plants, were higher than those in wild-type plants after inoculation with the blast isolate (<i>Magnaporthe oryzae</i> Barr). In addition, the expression level of <i>OsGF14f</i> was significantly induced after SA treatment, and higher endogenous SA levels were observed in the <i>Os</i><i>GF14f</i>-overexpressing plants compared with that in wild-type plants, especially after blast challenge. Taken together, these results suggest that <i>Os</i><i>GF14f</i> positively regulates leaf blast and bacterial blight resistance in rice via the SA-dependent signaling pathway.
An Outbreak ofMycobacterium chelonaeInfection Following Liposuction (2002)

Among 82 patients who underwent liposuction performed by a single practitioner in a 6-month period, 34 (41%) developed cutaneous abscesses. An organism identified as Mycobacterium chelonae by polymerase chain reaction restriction-enzyme analysis was recovered from cultures of samples from 12 of those patients. DNA large restriction-fragment pattern analysis by pulsed-field gel electrophoresis demonstrated that a strain of M. chelonae recovered from biofilm in the piped-water system in one of the physician's offices differed by only 2 restriction fragments from the 12 patient isolates, which differed from each other by 0 or 1 restriction fragment. A detailed retrospective cohort study that included interviews with former employees and statistical analysis of risk factors indicated that inadequate sterilization and rinsing of surgical equipment with tap water were likely sources of mycobacterial contamination. This is the first reported outbreak of nosocomial infection due to M. chelonae in which a source has been identified and the first to occur in association with liposuction in patients in the United States.
Electric power distribution handbook (2004)

Of the ...big three... components of the electricity infrastructure, distribution typically gets the least attention, and no thorough, up-to-date treatment of the subject has been published in years. Filling that void, the Electric Power Distribution Handbook provides comprehensive information on the electrical aspects of power distribution systems. It is an unparalleled source for the background information, hard-to-find tables, graphs, methods, and statistics that power engineers need, and includes tips and solutions for problem solving and improving performance. In short, this handbook gives readers the tools they need to understand the science and practices of distribution systems.
Effect of culture conditions on astaxanthin formation in red yeast Xanthophyllomyces dendrorhous mutant JH1 (2006)

The formation of astaxanthin by Xanthophyllomyces dendrorhous mutant JH 1 depends on the culture conditions. Therefore, the effects of inoculation rate (1-5%, v/v) and medium compositions (various carbon and nitrogen sources) on cell growth and astaxanthin formation in X. dendrorhous mutant JH1 were investigated. Inoculation at 3% (v/v) was optimal for cell growth and astaxanthin formation. The most effective carbon source for cell growth and astaxanthin formation was glucose, and the best nitrogen source was yeast extract. The 3% (w/v) glucose and 0.2% (w/v) yeast extract showed the best effect on cell growth and astaxanthin formation, compared with others tested. The 3% glucose, 0.2% yeast extract, 0.15% KH 2 PO 4 , 0.05% MgSO 4 , 0.01% MnSO 4 , and 0.01% CaCl 2 were selected for cell growth and astaxanthin formation. Under the conditions selected, the maximum concentrations of cell and astaxanthin obtained after 168 h of cultivation were 5.43 g/l and 28.20 mg/l, respectively.
Predicting disease risks from highly imbalanced data using random forest (2011)

In combining repeated random sub-sampling with RF, we were able to overcome the class imbalance problem and achieve promising results. Using the national HCUP data set, we predicted eight disease categories with an average AUC of 88.79%.
Bioinformatic and mechanistic analysis of the palmerolide PKS-NRPS biosynthetic pathway from the microbiome of an Antarctic ascidian (2021)

Abstract Complex interactions exist between microbiomes and their hosts. Increasingly, defensive metabolites that have been attributed to host biosynthetic capability are now being recognized as products of host-associated microbes. These unique metabolites often have bioactivity targets in human disease and can be purposed as pharmaceuticals. Polyketides are a complex family of natural products that often serve as defensive metabolites for competitive or pro-survival purposes for the producing organism, while demonstrating bioactivity in human diseases as cholesterol lowering agents, anti-infectives, and anti-tumor agents. Marine invertebrates and microbes are a rich source of polyketides. Palmerolide A, a polyketide isolated from the Antarctic ascidian Synoicum adareanum , is a vacuolar-ATPase inhibitor with potent bioactivity against melanoma cell lines. The biosynthetic gene clusters (BGCs) responsible for production of secondary metabolites are encoded in the genomes of the producers as discrete genomic elements. A candidate palmerolide BGC was identified from a S. adareanum microbiome-metagenome based on a high degree of congruence with a chemical structure-based retrobiosynthetic prediction. Protein family homology analysis, conserved domain searches, active site and motif identification were used to identify and propose the function of the ∼75 kb trans -acyltransferase (AT) polyketide synthase-non-ribosomal synthase (PKS-NRPS) domains responsible for the stepwise synthesis of palmerolide A. Though PKS systems often act in a predictable co-linear sequence, this BGC includes multiple trans -acting enzymatic domains, a non-canonical condensation termination domain, a bacterial luciferase-like monooxygenase (LLM), and is found in multiple copies within the metagenome-assembled genome (MAG). Detailed inspection of the five highly similar pal BGC copies suggests the potential for biosynthesis of other members of the palmerolide chemical family. This is the first delineation of a biosynthetic gene cluster from an Antarctic microbial species, recently proposed as Candidatus Synoicohabitans palmerolidicus. These findings have relevance for fundamental knowledge of PKS combinatorial biosynthesis and could enhance drug development efforts of palmerolide A through heterologous gene expression.
The protomap is propagated to cortical plate neurons through an Eomes -dependent intermediate map (2013)

The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a "protomap" in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here we show that the VZ, subventricular zone (SVZ), and CP contain distinct molecular maps of regional identity, reflecting different gene expression gradients in radial glia progenitors, intermediate progenitors, and projection neurons, respectively. The "intermediate map" in the SVZ is modulated by Eomes (also known as Tbr2), a T-box TF. Eomes inactivation caused rostrocaudal shifts in SVZ and CP gene expression, with loss of corticospinal axons and gain of corticotectal projections. These findings suggest that cortical areas and connections are shaped by sequential maps of regional identity, propagated by the Pax6 → Eomes → Tbr1 TF cascade. In humans, PAX6, EOMES, and TBR1 have been linked to intellectual disability and autism.
Behavior of Riders of Electric Bicycles at Onset of Green and Yellow at Signalized Intersections in China (2012)

In most Chinese cities, electric bicycles and electrically assisted bicycles (e-bikes) have drastically increased in recent years and currently constitute the largest proportion of the nonmotorized traffic at signalized intersections. Proper treatment of e-bikes has become a vitally important issue in improving the operational efficiency and safety performance of signalized intersections. However, fundamental knowledge of the unique operating characteristics and behavior of riders of e-bikes under various conditions is insufficient. This study statistically analyzed critical behavioral parameters of e-bike riders and empirically modeled their start-up behavior at the green onset following a 3-s red-and-yellow signal and their stop–pass decision behavior at the yellow onset following a 3-s flashing green. Distribution types and parameters of desired speed, start-up time, acceleration rate, perception–reaction time, and deceleration rate were investigated with the use of highly accurate trajectory data. A temporal–spatial model was developed to interpret the start-up curve, and three binary logistic regression models were built to predict the stop–pass decisions for different rider groups. It was found that the start-up curve of e-bikes could be well described by a quadratic function and that the red-and-yellow signal significantly induced a hurried start. The potential time to the stop line at the decision point was found to be the dominant independent factor explaining the stop–pass decision of e-bike riders; the flashing green signal seemed to enlarge the option zone, bring the indecision zone earlier, and result in more aggressive passing behavior.