gebhart/patrepeval huggingface dataset:
The phonetic footprint of Parkinson's disease (2021)

Abstract As one of the most prevalent neurodegenerative disorders, Parkinson’s disease (PD) has a significant impact on the fine motor skills of patients. The complex interplay of different articulators during speech production and realization of required muscle tension become increasingly difficult, thus leading to a dysarthric speech. Characteristic patterns such as vowel instability, slurred pronunciation and slow speech can often be observed in the affected individuals and were analyzed in previous studies to determine the presence and progression of PD. In this work, we used a phonetic recognizer trained exclusively on healthy speech data to investigate how PD affected the phonetic footprint of patients. We rediscovered numerous patterns that had been described in previous contributions although our system had never seen any pathological speech previously. Furthermore, we could show that intermediate activations from the neural network could serve as feature vectors encoding information related to the disease state of individuals. We were also able to directly correlate the expert-rated intelligibility of a speaker with the mean confidence of phonetic predictions. Our results support the assumption that pathological data is not necessarily required to train systems that are capable of analyzing PD speech.
Why do they come? A review of individual student learning appointments (2009)

With the increasing diversity of the first year student cohort, tertiary institutions are under pressure to provide a range of programs that enhance transition into university study. At the University of Tasmania (UTAS) a suite of student learning support programs sit alongside other initiatives for commencing students. This paper describes the evaluation of an initiative where individual student appointments were offered to students who self-reported issues with their university studies. Whilst the student feedback is overwhelmingly positive, the authors question how this strategy can be extended to better serve the needs of at risk students.
The Effects of Herbicides Targeting Aromatic and Branched Chain Amino Acid Biosynthesis Support the Presence of Functional Pathways in Broomrape (2017)

It is not clear why herbicides targeting aromatic and branched-chain amino acid biosynthesis successfully control broomrapes-obligate parasitic plants that obtain all of their nutritional requirements, including amino acids, from the host. Our objective was to reveal the mode of action of imazapic and glyphosate in controlling the broomrape <i>Phelipanche aegyptiaca</i> and clarify if this obligatory parasite has its own machinery for the amino acids biosynthesis. <i>P. aegyptiaca</i> callus was studied to exclude the indirect influence of the herbicides on the parasite through the host plant. Using HRT - tomato plants resistant to imidazolinone herbicides, it was shown that imazapic is translocated from the foliage of treated plants to broomrape attachments on its roots and controls the parasite. Both herbicides inhibited <i>P. aegyptiaca</i> callus growth and altered the free amino acid content. Blasting of <i>Arabidopsis thaliana</i> 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) and acetolactate synthase (ALS) cDNA against the genomic DNA of <i>P. aegyptiaca</i> yielded a single copy of each homolog in the latter, with about 78 and 75% similarity, respectively, to <i>A. thaliana</i> counterparts at the protein level. We also show for the first time that both EPSPS and ALS are active in <i>P. aegyptiaca</i> callus and flowering shoots and are inhibited by glyphosate and imazapic, respectively. Thus leading to deficiency of those amino acids in the parasite tissues and ultimately, death of the parasite, indicating the ability of <i>P. aegyptiaca</i> to synthesize branched-chain and aromatic amino acids through the activity of ALS and EPSPS, respectively.
Development of metallic nanostructures for biosensing (2005)

Surface-Enhanced-Raman-Scattering (SERS) is potentially a very sensitive spectroscopic technique for the detection of biological agents (i.e., proteins, viruses or bacteria). However, since initial reports, its utility has not been realized. Its limited acceptance as a routine analysis technique for biological agents is largely due to the lack of reproducible SERS-active substrates. Most established SERS substrate fabrication schemes are based on self-assembly of the metallic (typically, Au, Ag, Pt, Pd or Cu) particles responsible for enhancement. Further, these protocols do not lend themselves to the stringent control over the enhancing feature shape, size, and placement on a nanometer scale. SERS can be made a more robust and attractive spectroscopic technique for biological agents by developing quantifiable, highly sensitive, and highly selective SERS-active substrates. Electron Beam Lithography (EBL), a semiconductor fabrication technique, can be utilized to address many of the obstacles which have limited the broad acceptance of SERS. Specifically, EBL can be employed to precisely control the shape, size and position (on a nanometer scale) of the SERS substrate enhancing features. Since Ashkin's seminal work in the early 1970s, the optical trapping phenomenon has been broadly accepted as a powerful tool to study micrometer-scale biological particles. Recently, research in our laboratory has demonstrated that it is possible to combine the Optical Trapping phenomenon and SERS to develop a high sensitivity spectroscopic technique for the detection of individual bacterial spores. Highly reproducible SERS-active substrates fabricated using EBL have been utilized with this novel spectroscopic technique to investigate the utility of SERS technique for the spectral discrimination of bacterial spores. The SERS substrate fabrication methodology, substrate reproducibility and SERS spectral reproducibility will be discussed.
Improved Laser Angular Brightness Through Diffraction Coupling (1964)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. T. LaTourette, S. F. Jacobs, and P. Rabinowitz, "Improved Laser Angular Brightness Through Diffraction Coupling," Appl. Opt. 3, 981_1-982 (1964) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder. (1985)

The efficacy of fluoxetine was evaluated in depressed patients in double-blind imipramine- and placebo-controlled clinical trials. Fluoxetine produced greater improvement than placebo on all major efficacy parameters and was comparable to imipramine with respect to the primary indicators of depression. Fluoxetine had significantly less associated anticholinergic effects, dizziness, drowsiness, somatosensory disturbance, and excessive sweating than imipramine. Although nausea occurred more frequently in fluoxetine patients, it was generally mild and well tolerated. A significantly smaller percentage of fluoxetine than imipramine patients terminated therapy because of adverse experiences.
Bad channel detection in EEG recordings (2022)

Abstract Electroencephalography (EEG) is widely used in clinical applications and basic research. Dry EEG opened the application area to new fields like self-application during gaming and neurofeedback. While recording, the signals are always affected by artefacts. Manual detection of bad channels is the gold standard in both gel-based and dry EEG but is timeconsuming. We propose a simple and robust method for automatic bad channel detection in EEG. Our method is based on the iterative calculation of standard deviations for each channel. Statistical measures of these standard deviations serve as indications for bad channel detection. We compare the new method to the results obtained from the manually identified bad channels for EEG recordings. We analysed EEG signals during resting state with eyes closed and datasets with head movement. The results showed an accuracy of 99.69 % for both gel-based and dry EEG for resting state EEG. The accuracy of our new method is 99.38 % for datasets with the head movement for both setups. There was no significant difference between the manual gold standard of bad channel identification and our iterative standard deviation method. Therefore, the proposed iterative standard deviation method can be used for bad channel detection in resting state and movement EEG recordings.
Actively Tuned Plasmons on Elastomerically Driven Au Nanoparticle Dimers (2010)

We demonstrate a novel way to actively tune surface plasmons by fabricating plasmonic nanostructures on stretchable elastomeric films. This allows reversible modification of the metal geometry on the nanometer scale. Using 100 nm scale Au nanoparticle dimers whose spacing is stretch-tuned reveals radically different spectral tuning than previously reported for sub-10-nm nanoparticles, but which can be explained by a revised interpretation of existing models. Tuning plasmons in this way offers a much more robust way than lithography to interrogate the physics of localized plasmons and has applications in optimized surface-enhanced luminescence and Raman scattering.
Prokaryotic Nucleotide Excision Repair (2013)

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into the structure and function of NER components. This ensemble of proteins orchestrates faithful removal of toxic DNA lesions through a multistep process. The damaged nucleotide is recognized by dynamic probing of the DNA structure that is then verified and marked for dual incisions followed by excision of the damage and surrounding nucleotides. The opposite DNA strand serves as a template for repair, which is completed after resynthesis and ligation.
Closed Humeral Fracture Complicated with Acute Hematogenous Osteomyelitis: A Case Report. (2018)

Although AHO complicating a closed fracture in immunocompetent adults is very rare, it should not be overlooked, and special attention should be sought in such cases. Meticulous debridement and rigid fixation are utmost for the eradication of infection and fracture union. Patients presenting with such infections should, therefore, be followed closely and treated promptly.
A New Preparation Method for Well-Controlled 3D Skeletal Epoxy Resin-Based Polymer Monoliths (2005)

ADVERTISEMENT RETURN TO ISSUECommunication to the...Communication to the EditorNEXTA New Preparation Method for Well-Controlled 3D Skeletal Epoxy Resin-Based Polymer MonolithsNorio Tsujioka, Natsuki Hira, Satoshi Aoki, Nobuo Tanaka, and Ken HosoyaView Author Information Department of Polymer Science & Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan, and Asahi Chemical Co., 515 Kojima-cyo, Moriyama, Shiga 524-0002, Japan Cite this: Macromolecules 2005, 38, 24, 9901–9903Publication Date (Web):October 27, 2005Publication History Received30 June 2005Revised12 October 2005Published online27 October 2005Published inissue 1 November 2005https://pubs.acs.org/doi/10.1021/ma051409hhttps://doi.org/10.1021/ma051409hrapid-communicationACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views1411Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalyst supports,Monomers,Polymerization,Polymers,Solvents Get e-Alerts
Synthesis and characterization of aluminum–polyaniline thin films and membranes (2005)

Abstract Polyaniline (PAni) films of different intrinsic oxidation states, including emeraldine salt, emeraldine base and leucoemeraldine base, were synthesized. Free‐standing membranes and thin film bilayers of aluminum–polyaniline were fabricated by magnetron sputter deposition of aluminum onto polyaniline films. Aluminum–polyaniline samples were analyzed by transmission electron microscopy (TEM) to investigate the microstructures of specimens, including cross‐sectional TEM micrographs of the metal‐polyaniline interfacial structure not previously reported in the literature. Auger electron spectroscopy (AES) and X‐ray photoelectron spectroscopy (XPS) were employed to study the chemical bonding and interaction between deposited aluminum and polyaniline at the interface. Results indicated that the intrinsic oxidation state of the polyaniline influenced the chemistry of the aluminum–polyaniline interface. Distinct interaction between aluminum and polyaniline in the emeraldine salt‐form was observed. However, there was no evidence of direct interactions of the aluminum with emeraldine base and leucoemeraldine base polyaniline. Copyright © 2005 John Wiley &amp; Sons, Ltd.
NB-IoT Micro-Operator for Smart Campus: Performance and Lessons Learned in 5GTN (2020)

In recent years, many new radio-based connectivity solutions for the Internet of Things (IoT) have been proposed. At the same time, development towards the 6G has brought on the stage the new business concepts. One of them is the concept of a micro-operator and implies the local entities to act as the telecom infrastructure owner and provider in their premises. In the current paper, we discuss the deployment and report the practical performance of a single-cell NB-IoT deployed as a part of the 5G Test Network (5GTN) and controlled by a smart-campus micro-operator. The practical measurements reported in the paper have been carried in the University of Oulu within a huge interconnected indoor environment with the total floor area of 188 600 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Our results demonstrate that the NB-IoT technology is a viable connectivity solution for various non-critical machine-based applications deployed indoors, highlight the practical performance of this technology, and reveal some practical specifics and challenges of acting as an IoT micro-operator.
Metal Exposure Among Abrasive Blasting Workers at Four U.S. Air Force Facilities (2000)

Button Aerosol Samplers were used to monitor the personal exposure of workers performing abrasive blasting operations at four U.S. Air Force facilities. Inhalable aerosols containing 25 metals, including cadmium, lead, and chromium, were investigated. The Button Aerosol Sampler was chosen because of its ability to successfully withstand mechanical stress, prevent very large particles from collection, and protect the filter from overloading and shredding by rebound particles. In addition, previous studies have shown that the sampling efficiency of this personal Aerosol Sampler exhibits low sensitivity to the ambient air conditions and that it adequately follows the inhalability convention. Inductively coupled plasma (ICP) was used to analyze the collected samples for all 25 metals. In addition, visual absorption spectrophotometry (VAS) was used to analyze for hexavalent chromium because of the presence of strontium chromate. The collected samples yielded 8-hr time-weighted average (TWA) concentrations that were up to 250, 6, and 5 times higher than the permissible exposure limits (PELs) for cadmium, lead, and hexavalent chromium, respectively. Also, the chromium levels measured by the ICP and VAS exceeded the strontium chromate threshold limit value (TLV) by up to 640 and 950 times, respectively. No correlation was found between the ICP and VAS hexavalent chromium concentrations. The likely reasons of this were the presence of Cr (II) and (III) that cannot be detected by the VAS, and the chemical interference from iron and some other metals in the samples. The Button Aerosol Sampler was shown to be useful for the monitoring of workers' exposure to heavy metals during abrasive blasting operations.
ESR and NMR studies of sodium and rubidium loaded in NaY zeolite cavities (1993)

3 pages
Obtención de circonas estabilizadas (Ca,Mg-PSZ) nanocristalinas a partir de mezclas de dolomita y circona monoclínica mediante molienda de alta energía (2003)

El objetivo del presente trabajo es la obtención de materiales cerámicos de circona estabilizada (Ca,Mg-PSZ) nanocristalina mediante molienda de alta energía, a partir de circona monoclínica comercial y una materia prima de alta pureza y bajo coste como es la dolomita (CaMg(CO3)2). La molienda de alta energía de mezclas, especialmente en la que al menos uno de los componentes contenga un grupo carbonato, hidroxilo o se lleve a cabo en presencia de agua, se ha convertido en un método alternativo para obtener materiales nanocristalinos. En este trabajo, mediante un molino de bolas de alta energía se han obtenido nanopartículas de circona monoclínica y dolomita con un tamaño medio de cristalito de 20 ± 5 nm. A partir de estas se han preparado materiales cerámicos densos (98 %ñ/ñt) de circona (Ca, Mg-PSZ) nanocristalina por sinterización a 1200º y 1300ºC durante 18 y 48 minutos
ChemInform Abstract: COBALT(I) PHTHALOCYANINE SALTS, STABLE ′SUPERNUCLEOPHILIC′ VITAMIN B12 MODEL SUBSTANCES IN NEUTRAL MEDIUM (1976)

Abstract Das Phthalocyaninatocobaltat(I), das nach einer bekannten Methode erhalten wurde, ist als Li‐Salz gegenüber Sauerstoff und Wasser sehr empfindlich, bildet aber bei deren Ausschluß mit Äthanol und Methanol stabile neutrale Lösungen, in denen es supernucleophile Eigenschaften hat.
A thermal model of the conical evaporator in Pluto/Express, multi-tube AMTEC cells (1999)

A detailed thermal model of the conical evaporator of Pluto/Express AMTEC cells is developed to evaluate the effect of evaporator cone angle (between 0° and 90°) on the cell performance and temperature margin. The model calculates the effect of the cone angle on the vapor exit temperature and mass flow rate as a function of the cell design, operating hot side and condenser temperatures, external load resistance, and the design and type of the structure materials of the evaporator standoff. This paper describes the evaporator thermal model, and the numerical approach and method of solution used. Results were not available at the time of publication, but will be presented at the conference.
Dynamic mechanical behavior of partially hydrolyzed ethylene‐vinyl acetate copolymers (1971)

Abstract A dynamic mechanical study has been made of two series of partially hydrolyzed ethylene‐vinyl acetate copolymers. Series A contains 75 mole % ethylene and series B contains 59 mole % ethylene. The frequencies employed were 3.5, 11, and 110 Hz, and the temperature range was from −180° to +120°C. Three relaxation regions are discernable in this range and these are labeled α, β, and γ in order of decreasing temperature. The α relaxation is associated with the glass transition of the copolymers. The β relaxation is absent in the unhydrolyzed copolymers and is dependent on hydroxyl content. It is assigned to local motions of hydrogen bonded groups. The γ relaxation is insensitive to hydroxyl content and is assigned to local motions of methylene sequences. The above assignments are supported by the effect of water added to the polymers. Added water decreases the temperatures of the α and β relaxations but does not affect the γ relaxation significantly. The magnitude of the β relaxation is considerably enhanced by water.
Cross-flow microfiltration for lab-on-chip defatting of human breast milk (2008)

Determining the lactose concentration in human breast milk (HBM) via standard assay techniques requires fat removal from the milk (defatting), followed by lactose detection in the remaining skim milk. This work focuses on methods of defatting which can be subsequently integrated in the same Lab-on-Chip (LOC) as the lactose measurement. One method under study for defatting HBM is the use of a cross-flow microfiltration structure. This kind of microfiltration prevents clogging and separates the large fat globules from the smaller nutrition constituents of milk, of which lactose is amongst the smallest. To test if large fat globules may clog the channel or not, the biocompatibility of PMMA and HBM was studied. The weight of absorbed fat on the surface of PMMA was found to be 3-orders of magnitude lower than that of the total fat in HBM. Photolithgraphy using SU-8 was applied for mold fabrication; however, hot-embossing using SU-8 mold has not been successful due to the high stress resulting in the demolding process. To improve mold strength, nickel molds were fabricated by electroplating using different current densities. As expected, the deposition rates were found to have a linear relationship with applied current density, while the smaller features have a higher deposition rate than larger features.
Immune tolerance induction for laronidase treatment in mucopolysaccharidosis I (2017)

NCT00741338.
Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein (2001)

It has been demonstrated that proinsulin C-peptide possesses several biological activities and that its specific binding sites are present on the surface of cell membranes. However, the molecular and cellular mechanisms of C-peptide actions are poorly known. In the present study we examined the possible involvement of the mitogen-activated protein kinase (MAPK) pathway in C-peptide effects. C-peptide induced the phosphorylation of MAPK [p44 extracellular signal-regulated kinase 1 (ERK1) and p42 ERK2] in Swiss 3T3 and 3T3-F442A fibroblasts but not in 3T3-L1 fibroblasts and some other cell lines such as L6E9 muscle cells. In Swiss 3T3 cells, C-peptide-induced phosphorylation of MAPK was dependent on time and concentration, being maximal at 1min and at 1nM C-peptide and was accompanied by an increase in MAPK activity and MAPK kinase (MEK) phosphorylation. The MAPK phosphorylation by C-peptide was abolished by treatment with pertussis toxin (PTX) and also with a MEK inhibitor, PD 98059. In addition, MAPK phosphorylation was attenuated by treatment with a phosphoinositide 3-kinase (PI-3K) inhibitor, wortmannin, and with a protein kinase C (PKC) inhibitor, GF109203X, and by down-regulation of PKC by prolonged treatment with PMA. Similar effects of the inhibitors and PTX were found on the MAPK phosphorylation induced by neuropeptide Y. These results suggest that C-peptide activates MAPK through a putative Gi/Go-linked receptor for C-peptide and through PI-3K-dependent and PKC-dependent pathways.