gebhart/patrepeval huggingface dataset:
The Americans with Disabilities Act: promise or problem? (1997)

Now that some states have restricted workers' compensation claims related to stress, the author predicts that the Americans with Disabilities Act, with its many ambiguous definitions, will become a favored target of litigation brought by employees seeking redress for work-related grievances. The ADA is reviewed in terms of the potential problems that employees increasingly are facing in regard to mental disabilities.
Multiply resistant mutants of Enterobacter cloacae selected by beta-lactam antibiotics (1986)

Mutants of Enterobacter cloacae, selected in vitro with ceftriaxone, ceftazidime, carumonam, or aztreonam, fell into several distinct classes. Three mutants highly resistant to nearly all beta-lactam antibiotics were stably derepressed for beta-lactamase production. Although no other changes could be detected, virulence in a mouse septicemia model was decreased in two of these mutants. One mutant, 908-Ssi, showed selectively decreased susceptibility to ampicillin and cefotetan. A change in beta-lactamase expression was thought to be responsible for this. Alterations in the production of two outer membrane proteins with molecular sizes of 36.5 and 39 kilodaltons were responsible for multiple antibiotic resistance in two mutants, both of which acquired a low level of resistance to beta-lactam antibiotics. Whereas one of the mutants, AMA-R, simultaneously acquired resistance to chloramphenicol and trimethoprim, the other, AZT-R, became hypersusceptible to these and other hydrophobic agents. Both strains had drastically reduced virulence in mice.
Attempted copolymerization of 1.3‐dioxolane with tetrahydrofuran by triethyl oxonium tetrafluoroborate (1970)

Abstract Copolymerization of 1,3‐dioxolane (DOL) with tetrahydrofuran (THF) was attempted with triethyl oxonium tetrafluoroborate (Et 3 OBF 4 ) as initiator. The gas chromatographic determination of the unreacted monomers during the reaction indicated that preferential polymerization of THF occurred in the initial stage of the reaction, and that once DOL began to polymerize after an induction period, the polymerization of THF declined gradually and ceased. However, it was resumed, although very slowly, after the polymerization of DOL reached the equilibrium conversion. Two‐step polymerizations of THF and DOL by utilizing the living nature of the polymerization by Et 3 OBF 4 yielded a mixture of the homopolymers. The mechanism of this unusual polymerization is discussed. The addition of THF to the cationic chain ends with DOL as the terminal unit does not occur but proton transfer takes place.
Structural and Selective Gas Adsorption Studies of Polyoxometalate and Tris(ethylenediamine) Cobalt(III) Based Ionic Crystals (2010)

Seven new ionic solids built on polyoxometalate anions and [Co(en)3]3+ cations, namely, [Co(en)3Mo8O26(H3O)(Cl)](DMF)4(H2O) (Co-Mo8-DMF), [α-PW12O40][Co(en)3]·6DMF (Co-W12P-DMF), [α-PW12O40][Co(en)3]·6DEF (Co-W12P-DEF), [α-PMo12O40][Co(en)3]·5.5DMF (Co-Mo12P-DMF), [α-PMo12O40][Co(en)3]·6DEF (Co-Mo12P-DEF), [α-SiW12O40][Co(en)3]3/2[Cl]1/2·6DMF·3H2O (Co-W12Si-DMF), and [α-SiW12O40][Co(en)3]·6DEF (Co-W12Si-DEF), have been synthesized from nonaqueous (DMF/DEF) media and characterized by single-crystal X-ray diffraction. We attempt to understand if [Co(en)3]3+ cations used in these reaction systems play a crucial role in controlling the assembly of these crystals. These ionic solids, after removal of the DMF or DEF molecules, are found to exhibit size selective H2 adsorption properties over N2. The amount of hydrogen adsorption was influenced by POM anion types and their orientations. CoMo12P-DEF has the highest (0.9 wt %) H2 uptake, and CoW12P-DEF has the lowest (0.4 wt %) uptake among the series when the adsorbate pressure approached 1 atm.
An Analytical Model for Tailor Welded Blank Forming (2003)

Tailor Welded Blanks (TWBs) offer several notable benefits including decreased part weight, reduced manufacturing costs, increased environmental friendliness, and improved dimensional consistency. In order to take advantage of these benefits, however, designers need to overcome the reduced formability of TWBs and be able to accurately predict unique characteristics related to TWB forming early in the design process. In this paper, an analytical model to predict the weld line movement and forming height for a uniform binder force, TWB forming application is presented. Comparison to numerical simulation results demonstrates the accuracy of this methodology. The analytical model provides designers a valuable tool to determine the location of steps on the die surface to accommodate the weld line movement and the potential forming height for a TWB forming with a uniform binder force. The methodology presented here has the potential to be extended to analyze a non-uniform binder force forming of TWBs.
Biological Functions of IgA (2007)

Immunoglobulin A (IgA) is the most enigmatic of immunoglobulins. It is by far the most abundant of human Igs, being present in the blood plasma at concentrations approximating 2–3mg/mL, as well as the dominant isotype in most secretions where its output amounts to some 5–8g/day in adults. Furthermore, its evolutionary origins appear to precede the synapsid– diapsid divergence in tetrapod phylogeny (>300 million years ago) because it is present in both mammals and birds and therefore possibly also in reptiles (reviewed in Peppard et al., 2005); an IgA-like molecule has now been identified in a lizard (Deza et al., 2007).
Supplementary Table 1 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia (2023)

&lt;p&gt;PDF file - 22K, Results of correlation analysis between miRNA expression and copy number.&lt;/p&gt;
Synthesis and Conformational Analysis of Novel N(OCH3)‐linked Disaccharide Analogues (2004)

N(OMe)-linked disaccharide analogues, isosteric to the corresponding natural disaccharides, have been synthesized by chemoselective assembly of unprotected natural monosaccharides with methyl 6-deoxy-6-methoxyamino-alpha-D-glucopyranoside in an aqueous environment. The coupling reactions were found to be chemo- and stereoselective affording beta-(1-->6) disaccharide mimics when using Glc and GlcNAc; in the case of Gal, the beta-anomer was prevalent (beta:alpha=7:1). An iterative method for the synthesis of linear N(OMe) oligosaccharide analogues was demonstrated, based on the use of an unprotected monosaccharide building block in which an oxime functionality at C-6 is converted during the synthesis into the corresponding methoxyamino group. The conformational analysis of these compounds was carried out by using NMR spectroscopy, ab initio, molecular mechanics, and molecular dynamics methods. Optimized geometries and energies of fourteen conformers for each compound have been calculated at the B3LYP/6-31G* level. Predicted conformational equilibria were compared with the results based on NMR experiments and good agreement was found. It appears that N(OMe)-linked disaccharide analogues exhibit a slightly different conformational behavior to their parent natural disaccharides.
Modified glycosylation of cellobiohydrolase I from a high cellulase‐producing mutant strain of Trichoderma reesei (1998)

Cellobiohydrolase I is an industrially important exocellulase secreted in high yields by the filamentous fungus Trichoderma reesei. The nature and effect of glycosylation of CBHI and other cellulolytic enzymes is largely unknown, although many other structural and mechanistic aspects of cellulolytic enzymes are well characterised. Using a combination of liquid chromatography, electrospray mass spectrometry, solid-phase Edman degradation, and monosaccharide analysis we have identified every site of glycosylation of CBHI from a high cellulase-producing mutant strain of T. reesei, ALKO2877, and characterised each site in terms of its modifying carbohydrate and site-specific heterogeneity. The catalytic core domain comprises three N-linked glycans which each consist of a single N-acetylglucosamine residue. Within the glycopeptide linker domain, all eight threonines are variably glycosylated with between at least one, and up to three, mannose residues per site. All serines in this domain are at least partially glycosylated with a single mannose residue. This linker region has also been shown to be sulfated by a combination of ion chromatography and collision-induced dissociation electrospray mass spectrometry. The sulfate is probably mannose-linked. The biological significance of N-linked single N-acetylglucosamine in the catalytic core, and mannose sulfation in the linker region, is not known.
A Novel Design for Memristor-Based Multiplexer Via NOT-Material Implication (2017)

This paper proposes a novel memristor-based multiplexer implemented by using NOT-material implication. The proposed design can be extended to arbitrary N-bit inputs and the enable-port can be added to improve its structure. Furthermore, this structure can be applied in the cascade circuit and crossbar array. A novel peripheral read circuit is introduced to overcome the problem that it is difficult to read out the operation results stored in crossbar array with large scales. The feasibility and correctness of our design is verified by the HSPICE simulation results with voltage threshold adaptive memristor model.
On Smart Gaze Based Annotation of Histopathology Images for Training of Deep Convolutional Neural Networks (2022)

Unavailability of large training datasets is a bottleneck that needs to be overcome to realize the true potential of deep learning in histopathology applications. Although slide digitization via whole slide imaging scanners has increased the speed of data acquisition, labeling of virtual slides requires a substantial time investment from pathologists. Eye gaze annotations have the potential to speed up the slide labeling process. This work explores the viability and timing comparisons of eye gaze labeling compared to conventional manual labeling for training object detectors. Challenges associated with gaze based labeling and methods to refine the coarse data annotations for subsequent object detection are also discussed. Results demonstrate that gaze tracking based labeling can save valuable pathologist time and delivers good performance when employed for training a deep object detector. Using the task of localization of Keratin Pearls in cases of oral squamous cell carcinoma as a test case, we compare the performance gap between deep object detectors trained using hand-labelled and gaze-labelled data. On average, compared to 'Bounding-box' based hand-labeling, gaze-labeling required 57.6% less time per label and compared to 'Freehand' labeling, gaze-labeling required on average 85% less time per label.
Higher-Order Coreference Resolution with Coarse-to-Fine Inference (2018)

Kenton Lee, Luheng He, Luke Zettlemoyer. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 2 (Short Papers). 2018.
ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure (1993)

To determine the relationship between reactive cardiac hypertrophy and the expression of angiotensin II (ANG II) receptors in surviving myocytes after infarction, large infarcts were produced in rats that were killed 2-3 days later. Measurements of global ventricular dynamics indicated that left ventricular failure and right ventricular dysfunction occurred in experimental animals. These alterations in ventricular pump function were associated with increases in ventricular weight-to-body weight ratio, indicative of developing cardiac hypertrophy. Such a response was coupled with a 6.6-fold increase in ANG II receptor mRNA in myocytes from the left ventricle. A 2.3-fold increase in the expression of ANG II receptor in myocytes from the right ventricle was also found. Radioligand binding assay documented a 44% increase in the density of ANG II receptors on left ventricular myocytes of infarcted hearts. To establish whether the induction of genes commonly associated with myocyte hypertrophy was present, the message for c-myc and c-jun was biventricularly assessed. Myocardial infarction was accompanied by overexpressions of c-myc and c-jun that were more prominent in left than in right ventricular myocytes. In conclusion, the enhanced expression of ANG II receptor and its receptor protein and c-myc and c-jun in myocytes may participate in the reactive growth processes of these cells after infarction.
OKBC: a programmatic foundation for knowledge base interoperability (1998)

The technology for building large knowledge bases (KBs) is yet to witness a breakthrough so that a KB can be constructed by the assembly of prefabricated knowledge components. Knowledge components include both pieces of domain knowledge (for example, theories of economics or fault diagnosis) and KB tools (for example, editors and theorem provers). Most of the current KB development tools can only manipulate knowledge residing in the knowledge representation system (KRS) for which the tools were originally developed. Open Knowledge Base Connectivity (OKBC) is an application programming interface for accessing KRSs, and was developed to enable the construction of reusable KB tools. OKBC improves upon its predecessor, the Generic Frame Protocol (GFP), in several significant ways. OKBC can be used with a much larger range of systems because its knowledge model supports an assertional view of a KRS. OKBC provides an explicit treatment of entities that are not frames, and it has a much better way of controlling inference and specifying default values. OKBC can be used on practically any platform because it supports network transparency and has implementations for multiple programming languages. In this paper, we discuss technical design issues faced in the development of OKBC, highlight how OKBC improves upon GFP, and report on practical experiences in using it.
Design for Manufacturability in Via Programmable Gate Arrays (2003)

In the fast-paced semiconductor industry, time to market means everything. Accommodating the shortened design cycles, however, is hampered by the ever-increasing design complexity. In addition, the continual drive to achieve higher performance (speed, area, power) has fueled the introduction of new manufacturing processes. Existing integrated circuit design methodologies, such as standard-cells designs are failing to cope with these conflicting requirements at a cost that is supported by ASIC product volumes. This report introduces a new regular logic fabric, Via Programmable Gate Arrays (VPGAs). By employing a regular structure, the design cycles can be greatly reduced. Moreover, as the technology dimensions continue scaling downward, the product yield at the ramp-up becomes a function of systematic faults. In order to meet the market demands, the new designs will have to focus on the Manufacturability in addition to the performance specifications. This report presents an overview and design corrections for the common failure mechanisms in modem Cu Integrated Circuit processes. Furthermore, an implementation of the CLB with a manufacturability focus is described.
Abstract 1657: Discovery of a first-in-class multifunctional TYMS non-classical antifolate inhibitors with potent in vivo activity that prolongs survival (2023)

Abstract Thymidylate synthase (TYMS/TS) is overexpressed in many cancer types and is commonly associated with advanced disease. TYMS catalyzes the de novo synthesis reaction of deoxythymidine monophosphate (dTMP), one of the building blocks of DNA. Although TYMS inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for drug resistance limiting overall benefit. Here we report a small molecule TYMS inhibitor and its two analogues that exhibit i) enhanced anti-tumor activity as compared to current fluoropyrimidines and antifolates without inducing TYMS overexpression, ii) are structurally distinct from classical antifolates, iii) extend survival in both pancreatic xenograft tumor models and hTS/Ink4a/Arf null genetically engineered mouse tumor model, iv) and are well tolerated with equal efficacy using either intraperitoneal or oral administration. Mechanistically, we confirm the compound and its analogues are a multifunctional non-classical antifolate, and we identify structural features allowing direct TYMS inhibition while also maintaining the ability to inhibit dihydrofolate reductase (DHFR). Collectively, this work identifies new non-classical antifolate inhibitors that optimize inhibition of thymidylate biosynthesis with a favorable safety profile highlighting potential for enhanced cancer therapy. Citation Format: Peter Elias Dib, Maria Guijarro, Patrick Kellish, Nick Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Derek Leas, Nick Borrero, Carlos Modenutti, Richard Bennett, Jonathan Licht, Robert McKenna, Adrian Roitberg, Frederic Kaye, Maria Zajac-Kaye. Discovery of a first-in-class multifunctional TYMS non-classical antifolate inhibitors with potent in vivo activity that prolongs survival [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1657.
Optical-Coherence-Tomographie in der Arteria carotis. Erste Evaluation und Vergleich mit IVUS im Schweinemodell (2005)

Ziele: Die Optical Coherence Tomographie (OCT) zeigte in Untersuchungen der Ophtalmologie und Dermatologie ein hohes Auflösungsvermögen, welches in einigen Bereichen sogar die der etablierten Untersuchungsmethoden IVUS und CT übertraf. In vorherigen Arbeiten wurde beschrieben, dass die OCT es erlaubt, die murale und die luminale Morphologie wie die Lumendimenssionen, Plaques, Thromben und Stentgeometrien zu unterscheiden Methode: Wir verglichen OCT und IVUS in der Arteria Carotis (AC) von Schweinen (n=5) 6 Monate nach Stentimplantation um die Restenoserate der Gefäße zu untersuchen. Die Gefäße wurden in vivo und in vitro untersucht. Ergebnis: Für die OCT mussten die Arterien mit einem Ballon geblockt und das Blut mit NaCl-Lösung ersetzt werden, wobei trotz völliger Occlussion ein Blutinflow die Qualität der OCT-Bildgebung limitierte. Die in vitro mit Formalin fixierten Gefäße zeigten in der OCT eine bessere Auflösung gegenüber dem IVUS. Die Arterienwand, der eingebrachte Stent und die Neointima konnten mit der OCT besser identifiziert werden als mit IVUS. Probleme ergaben sich wenn der Untersuchungskatheter nicht in der Mitte des Gefäßes lag, hierbei konnte nicht das ganze Gefäß mit abgebildet werden, und es resultierten Artefakte. Bei ausgeprägter Neointima wurde das OCT Signal schwächer und der Kontrast weniger. Vergleicht man den Grad der Restenose von OCT und IVUS ergaben sich keine signifikanten Unterschiede. Schlussfolgerung: Die OCT zeigte eine gute Bildqualität mit einem höheren Kontrast als der IVUS, mit momentan noch technische Limitation für den Einsatz in der AC, die durch Softwaremodifikationen beseitigt werden können. In zukünftigen Studien werden wir die Ergebnisse aus der OCT und dem IVUS mit histologischen Untersuchungen vergleichen.
Virtual Reality Technology (2003)

December 01 2003 Virtual Reality Technology Grigore Burdea, Grigore Burdea Wiley-Interscience Search for other works by this author on: This Site Google Scholar Philippe Coiffet Philippe Coiffet Wiley-Interscience Search for other works by this author on: This Site Google Scholar Author and Article Information Grigore Burdea Wiley-Interscience Philippe Coiffet Wiley-Interscience © 2004 Massachusetts Institute of Technology2004 Presence: Teleoperators and Virtual Environments (2003) 12 (6): 663–664. https://doi.org/10.1162/105474603322955950 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Grigore Burdea, Philippe Coiffet; Virtual Reality Technology. Presence: Teleoperators and Virtual Environments 2003; 12 (6): 663–664. doi: https://doi.org/10.1162/105474603322955950 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPRESENCE: Virtual and Augmented Reality Search Advanced Search This content is only available as a PDF. © 2004 Massachusetts Institute of Technology2004 Article PDF first page preview Close Modal You do not currently have access to this content.
The "Choose Your Own Beverage" Table (2018)

Swing Compass is a configurable recommendation system that turns tablet computers into a compass-like device whose interface shows recommended items at different directions. Turning the compass 90 degrees results in different sets of options. Based on the concept of embodied metaphor and choice architecture theory, the design aims to prompt people to reflect on their choices. The first instance of Swing Compass comes with a designed wooden case, turning one single tablet computer into a personal handheld compass. The second instance includes a designed round table, repurposing five tablet computers for a tabletop compass to be placed in public space. This paper describes and proposes a prototype demonstration of the Swing Compass table situated next to a café. The featured items include different kinds of drinks and containers, with connection to their destinations in the environment. The goal is to elicit reflection on the environmental impacts of choices of beverage.
The two stages hierarchical unsupervised learning system for complex dynamic scene recognition (2013)

The two stage hierarchical unsupervised learning system has been proposed for modeling complex dynamic surveillance and cyberspace systems. Using a modification of the expectation maximization learning approach, we introduced a three layer approach to learning concepts from input data: features, objects, and situations. Using the Bernoulli model, this approach models each situation as a collection of objects, and each object as a collection of features. Further complexity is added with the addition of clutter features and clutter objects. During the learning process, at the lowest level, only binary feature information (presence or absence) is provided. The system attempts to simultaneously determine the probabilities of the situation and presence of corresponding objects from the detected features. The proposed approach demonstrated robust performance after a short training period. This paper discusses this hierarchical learning system in a broader context of different feedback mechanisms between layers and highlights challenges on the road to practical applications.
Colloquium – The United States Armyʼs Emerging Physical Fitness Doctrine (2006)

not provided.
Mild cognitive impairment as a risk factor for Parkinson's disease dementia (2017)

This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence. © 2017 International Parkinson and Movement Disorder Society.