gebhart/patrepeval huggingface dataset:
Impact of Distributed Rate Limiting on Load Distribution in a Latency-sensitive Messaging Service (2021)

The cloud's flexibility and promise of seamless auto-scaling notwithstanding, its ability to meet service level objectives (SLOs) typically calls for some form of control in resource usage. This seemingly traditional problem gives rise to new challenges in a cloud setting, and in particular a subtle yet significant trade-off involving load-distribution decisions (the distribution of workload across available cloud resources to optimize performance), and rate limiting (the capping of individual workloads to prevent global over-commitment). This paper investigates that trade-off through the design and implementation of a real-time messaging system motivated by Internet-of-Things (IoT) applications, and demonstrates a solution capable of realizing an effective compromise. The paper's contributions are in both explicating the source of this trade-off, and in demonstrating a possible solution.
Tandem emulsification for high-throughput production of double emulsions (2017)

Core-shell double emulsions produced using microfluidic methods with controlled structural parameters exhibit great potential in a wide range of applications, but the low production rate of microfluidic methods hinders the exploitation of the capabilities of microfluidics to produce double emulsions with well-defined features. A major obstacle towards the scaled-up production of core-shell double emulsions is the difficulty of achieving robust spatially controlled wettability in integrated microfluidic devices. Here, we use tandem emulsification, a two-step process with microfluidic devices, to scale up the production. With this method, single emulsions are generated in a first device and are re-injected directly into a second device to form uniform double emulsions. We demonstrate the application of tandem emulsification for scalable core-shell emulsion production with both integrated flow focusing and millipede devices and obtain emulsions of which over 90% are single-core monodisperse double emulsion drops. With both mechanisms, the shell thickness can be controlled, so that shells as thin as 3 μm are obtained for emulsions 50 μm in radius.
A Framework for Incorporating a National Maritime Surveillance System into the European Common Information Sharing Environment (2021)

The Common Information Sharing Environment (CISE) is an ongoing cooperative development initiative that incrementally incorporates new participants and countries through integrations of facilities for European maritime surveillance. This paper outlines some key processes and technicalities required for becoming a part of the CISE, specifically for the case of a maritime surveillance department in Montenegro - Administration for Maritime Safety and Port Management (AMSPM). The content greatly derives from an ongoing European Union (EU) collaborative project - ANDROMEDA and shows the CISE components such as its data model, services and architecture compositions fitting with existing legacy systems for maritime surveillance. We also show some extracts from the Adriatic-Ionian trial, being conducted in the project, using the enhanced CISE features and involving partners from Italy, Greece and Montenegro. The examinations and general guidelines presented are particularly intended to give insights into operational capabilities for search and rescue missions, oil spills responses and general sea occurrences and conditions monitoring.
Predicting promoter activities of primary human DNA sequences (2011)

We developed a computer program that can predict the intrinsic promoter activities of primary human DNA sequences. We observed promoter activity using a quantitative luciferase assay and generated a prediction model using multiple linear regression. Our program achieved a prediction accuracy correlation coefficient of 0.87 between the predicted and observed promoter activities. We evaluated the prediction accuracy of the program using massive sequencing analysis of transcriptional start sites in vivo. We found that it is still difficult to predict transcript levels in a strictly quantitative manner in vivo; however, it was possible to select active promoters in a given cell from the other silent promoters. Using this program, we analyzed the transcriptional landscape of the entire human genome. We demonstrate that many human genomic regions have potential promoter activity, and the expression of some previously uncharacterized putatively non-protein-coding transcripts can be explained by our prediction model. Furthermore, we found that nucleosomes occasionally formed open chromatin structures with RNA polymerase II recruitment where the program predicted significant promoter activities, although no transcripts were observed.
Electrodeposition of Gallium on Liquid and Solid Gallium Electrodes in Alkaline Solutions (1962)

A galvanostatic short time transient method has been used to examine deposition and dissolution on gallium electrodes in alkaline solutions of gallic chloride. The cathodic metal deposition current was distinguished from the total current by current efficiency determinations in steady state.
ChemInform Abstract: Two Complementary Syntheses of Symmetrically‐Tetrasubstituted Cyclooctatetraenes. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic Scheduler Management Using Deep Learning (2020)

The ability to manage the distributed functionality of large multi-vendor networks will be an important step towards ultra-dense 5G networks. Managing distributed scheduling functionality is particularly important, due to its influence over inter-cell interference and the lack of standardization for schedulers. In this paper, we formulate a method of managing distributed scheduling methods across a small cluster of cells by dynamically selecting schedulers to be implemented at each cell. We use deep reinforcement learning methods to identify suitable joint scheduling policies, based on the current state of the network observed from data already available in the RAN. Additionally, we also explore three methods of training the deep reinforcement learning based dynamic scheduler selection system. We compare the performance of these training methods in a simulated environment against each other, as well as homogeneous scheduler deployment scenarios, where each cell in the network uses the same type of scheduler. We show that, by using deep reinforcement learning, the dynamic scheduler selection system is able to identify scheduler distributions that increase the number of users that achieve their quality of service requirements in up to 77% of the simulated scenarios when compared to homogeneous scheduler deployment scenarios.
Jasmonates Induce Both Defense Responses and Communication in Monocotyledonous and Dicotyledonous Plants (2014)

Jasmonic acid (JA) and its derivatives (jasmonates, JAs) are phytohormones with essential roles in plant defense against pathogenesis and herbivorous arthropods. Both the up- and down-regulation of defense responses are dependent on signaling pathways mediated by JAs as well as other stress hormones (e.g. salicylic acid), generally those involving the transcriptional and post-transcriptional regulation of transcription factors via protein modification and epigenetic regulation. In addition to the typical model plant Arabidopsis (a dicotyledon), advances in genetics research have made rice a model monocot in which innovative pest control traits can be introduced and whose JA signaling pathway can be studied. In this review, we introduce the dynamic functions of JAs in plant defense strategy using defensive substances (e.g. indole alkaloids and terpenoid phytoalexins) and airborne signals (e.g. green leaf volatiles and volatile terpenes) in response to biotrophic and necrotrophic pathogens as well as above-ground and below-ground herbivores. We then discuss the important issue of how the mutualism of herbivorous arthropods with viruses or bacteria can cause cross-talk between JA and other phytohormones to counter the defense systems.
A Critical Evaluation of the Performance of Optical Fiber Sensors for Monitoring Dynamic Strains (1996)

Abstract An experimental study is conducted to evaluate the applicability of optical fiber sensors in measuring strains under dynamic loading conditions. Both phase modulated and intensity modulated sensors are studied. The experiments are performed to characterize the high strain rate response of these sensors and test their ability to measure changes in dynamic strain resulting from one-dimensional stress wave propagation. The stress waves are generated using both compressive and tensile gas gun setups. Then, optical fiber sensors are employed to monitor the stress wave pulse as it propagates down the bar. The output from the optical fiber sensors is compared to strain gages mounted at the same location. The results demonstrate that only localized optical fiber sensors that are bonded over the entire sensing region can be used for monitoring dynamic strain fields.
ChemInform Abstract: IDENTIFICATION OF VOLATILE LACTONES BY NMR. I. SYNTHESIS OF Γ‐ AND Δ‐LACTONES AND ASSIGNMENTS IN THE CARBON‐13 NMR SPECTRA OF 4‐HYDROXYHEXANOIC AND 5‐HYDROXYHEPTANOIC ACID LACTONES (1976)

Abstract Ausgehend von den Dionen (I) werden durch Hydrolyse die Ketosäuren (II) erhalten, derenReduktion und Cyclisierung die Lactone (III) ergeben.
Noninvasive vascular ultrasound elastography of carotid arteries for stroke prevention (2008)

Carotid plaque rupture leading to stroke involves alteration of arterial wall mechanical properties. This paper addresses reproducibility and potential clinical impact of non-invasive vascular elastography. Fifteen symptomatic and 15 asymptomatic patients with greater than 50% stenoses of their internal carotids, and 15 control subjects were scanned independently by two radiologists. Radio-frequency cine-loops were acquired on left and right common and proximal internal carotids. For control subjects, homogeneous strains with successive compression and dilatation of the vascular wall from systole to diastole and few shear patterns were observed. The axial strain did not differ between recording sites, sides and radiologists (ANOVA, p &amp;gt; 0.19). For patients, heterogeneous axial strain patterns with both compression and dilatation of tissues within plaques were noted along with shear concentrations at interfaces of tissue structures. Despite similar blood pressures, larger mean instantaneous axial strains were measured in symptomatic (1.5 ± 0.6%) versus asymptomatic (1.2 ± 0.5%) patients in systole for common carotids (t-test, p &amp;lt; 0.02). To conclude, reproducible results were obtained for control subjects and in patients, larger axial strains in common carotids may be associated with plaque rupture. This new imaging method may become a unique approach to characterize vulnerable plaques for stroke prevention.
Band-pass plasmonic slot filter with band selection and spectrally splitting capabilities (2011)

An ultra-compact surface plasmon polaritons (SPPs) narrow band-pass filter based on a slot cavity is proposed and numerically investigated. Attributed to the coupled resonances in the cavity, the filter demonstrates pass-band selection capability. Also, by varying the positions of output waveguides, the filter shows the spectrally splitting function. Moreover, the combination of the adjustments to the length/width of the slot cavity and to the coupling distance provides more flexibility in design for the locations and widths of the pass-bands of the proposed filter.
A Semi-Markov Model for Control of Energy Storage in Utility Grids and Microgrids With PV Generation (2015)

Photovoltaic (PV) penetration levels in the power grid have significantly increased during the last years. However, issues such as cloud-induced intermittency in PV generation forces equipment on the electrical grid to cycle excessively, preventing PV generation from being considered as a reliable or dispatchable source of power, particularly by utilities. A semi-Markov process model is proposed to model PV power. Unlike existing models of PV power, the proposed model has a wide range of applicability across both small and large timescales. These applications include simulating PV power, short-term forecasting of PV power, design of rule-based controllers for energy storage units (ESU), and stochastic scheduling of ESU in conjunction with other resources. The model is applied to study two cases of coordinating ESU with PV generation. In the first case, the model serves to design a coordination scheme for a hybrid battery-ultracapacitor (UC) ESU where the UC serves to extend the lifetime of a lead-acid battery. In the second case, the model allows probabilistic scheduling in a standalone PV/diesel/battery-ESU microgrid. In both cases, the model improves performance in terms of either battery lifetime or fuel consumption.
Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA GUIDELINE PART I—Initial Work-up and Medical Management (2021)

The work up and medical management of BPH requires attention to individual patient characteristics, while also respecting common principles. Clinicians should adhere to recommendations and familiarize themselves with standards of BPH management.
Crisis económica y redacción de contratos (2010)

Hace unos meses, un periodico digital publico en su web un breve y certero articulo de Javier Benegas titulado ?por que no saldremos de la crisis?, en el cual apuntaba, entre otras, las siguientes respuestas: 
Porque este sistema politico impide que exista una economia abierta y competitiva. Y sin una economia abierta, competitiva y sin interferencias, la crisis sera endemica.
Porque los grandes negocios se hacen en los despachos, bajo las reglas de la libre competencia.
Porque aquellos que controlan los grandes negocios en connivencia con el poder politico condicionan luego la economia de escala, generando una situacion en la que las pequenas empresas han de aceptar unas reglas de funcionamiento y unas condiciones de pago extraordinariamente duras impuestas por quienes controlan el mercado.
Porque la realidad es que ante un gran negocio no son los bancos quienes financian a las grandes empresas la mayor parte del proyecto: son los pequenos empresarios y autonomos que trabajan en regimen de subcontrata los que financian a la gran empresa mediante un sistema de pagos abusivo e ilegal.
PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA (2023)

Abstract In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here we have identified a long noncoding RNA, PITAR (p53 Inactivating TRIM28 associated RNA), as an inhibitor of p53. PITAR is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We found that TRIM28 mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of PITAR. PITAR interaction with TRIM28 RNA stabilized TRIM28 mRNA, which resulted in increased TRIM28 protein levels, enhanced p53 ubiquitination, and attenuated DNA damage response. While PITAR silencing inhibited the growth of WT p53 containing GSCs in vitro and reduced glioma tumor growth in vivo, its overexpression enhanced the tumor growth and promoted resistance to Temozolomide. DNA damage also activated PITAR, in addition to p53, thus creating an incoherent feedforward loop. Thus, we establish an alternate way of p53 inactivation and propose PITAR, an oncogenic Cancer/testis lncRNA, as a potential therapeutic target.
Antigenic variation inGiardia lamblia (2009)

Giardia lamblia undergoes antigenic variation, both in vitro and within the intestines of infected individuals. Variant-specific surface proteins (VSPs) cover the entire surface of the trophozoites and are the main antigens recognized by the host. Only 1 of about 200 VSP genes encoded by the Giardia genome is expressed on the surface of individual Giardia cells at any time; however, VSP antigen switching occurs spontaneously. In the recent year, significant advances in the knowledge of the antigen switching process have been achieved, which strongly suggests that antigenic variation in Giardia is regulated at the post-transcriptional level by a mechanism similar to RNA interference (RNAi). Several enzymes of the RNAi pathway are directly involved in VSP mRNA silencing and/or translational repression. Although several questions remain regarding how individual VSP antigens are selected for expression on the parasite surface, it is clear that an epigenetic mechanism is involved. In this review, we summarize the characteristics of this fascinating mechanism, analyse conflicting information regarding the structure of VSPs as it relates to the host's immune response, and highlight the major issues that need to be resolved to fully understand antigenic variation in this important pathogen.
Embryonic Stem Cells Expressing Both Platelet Endothelial Cell Adhesion Molecule-1 and Stage-Specific Embryonic Antigen-1 Differentiate Predominantly into Epiblast Cells in a Chimeric Embryo1 (2004)

We examined the expression of cell-surface markers on subpopulations of mouse embryonic stem (ES) cells to identify those that were associated with cells that had the highest pluripotency. Flow cytometry analysis revealed a wide variation in the expression of platelet endothelial cell adhesion molecule 1 (PECAM-1) and stage-specific embryonic antigen (SSEA)-1 in ES cells. Almost all SSEA-1+ cells expressed a high level of PECAM- 1, and reversible repopulation was observed between PECAM- 1+SSEA-1+ and PECAM-1+SSEA-1- cells. The ES cells carrying the lacZ gene were sorted into three subpopulations: PECAM- 1-SSEA-1-, PECAM-1+SSEA-1-, and PECAM-1+SSEA-1+. Quantitative reverse transcription-polymerase chain reaction revealed a low level of Oct3/4 mRNA expression and an elevation in differentiation maker gene expression in PECAM-1- cells. To compare the pluripotency of these three subpopulations, a single cell from each was injected into eight-cell embryo and ES cells identified at later stages by X-gal staining. At the blastocyst stage, PECAM-1+ SSEA-1+/- cells were found to have differentiated into epiblast cells in high numbers. In contrast, PECAM- 1- cell derivatives localized in the primitive endoderm or trophectoderm. At 6.0-7.0 days post coitum, many PECAM-1+SSEA- 1+ cells were found in the epiblast, but few beta-gal+ cells were detected in any regions of embryos that were injected with cells from the other two populations. These results showed that the expression levels of PECAM-1 and SSEA-1 in ES cells correlated closely with their pluripotency and/or their ability to incorporate into the epiblast of chimeric embryos.
Delivery of vegetable oil suspensions in a shear thinning fluid for enhanced bioremediation (2015)

In situ anaerobic biological processes are widely applied for dechlorination of chlorinated solvents in groundwater. A wide range of organic substrates have been tested and applied to support the dechlorination processes. Vegetable oils are a promising type of substrate and have been shown to induce effective dechlorination, have limited geochemical impacts, and maintain good longevity. Because they are non-aqueous phase liquids, distribution of vegetable oils in the subsurface has typically been approached by creating emulsified oil solutions for injection into the aquifer. In this study, inexpensive waste vegetable oils were suspended in a shear-thinning xanthan gum solution as an alternative approach for delivery of vegetable oil to the subsurface. The stability, oil droplet size distribution, and rheological behavior of the oil suspensions that are created in the xanthan solutions were studied in batch experiments. The injectability of the suspensions and the oil distribution in a porous medium were evaluated in column tests. Numerical modeling of oil droplet transport and distribution in porous media was conducted to help interpret the column-test data. Batch studies showed that simple mixing of vegetable oil with xanthan solution produced stable suspensions of the oil as micron-size droplets. The mixture rheology retains shear-thinning properties that facilitate improved uniformity of substrate distribution in heterogeneous aquifers. Column tests demonstrated successful injection of the vegetable oil suspension into a porous medium. This study provides evidence that vegetable oil suspensions in xanthan gum solutions have favorable injection properties and are a potential substrate for in situ anaerobic bioremediation.
BETTER CONTROL OF BATCH REACTORS (2005)

RETURN TO ISSUEPREVNewsNEXTBETTER CONTROL OF BATCH REACTORSNew heat-transfer technology takes temperature control of batch reactors to unprecedented levelMICHAEL FREEMANTLEView Author Information C&EN, LONDONCite this: Chem. Eng. News 2005, 83, 47, 51–52Publication Date (Print):November 21, 2005Publication History Published online14 November 2010Published inissue 21 November 2005https://doi.org/10.1021/cen-v083n047.p051Copyright © 2005 American Chemical SocietyArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) SUBJECTS:Chemical engineering and industrial chemistry,Electrochemical engineering,Fluids,Pharmaceuticals,Pharmaceutics Get e-Alerts
Hormonal modulation of herpes simplex virus replication in a mouse neuroblastoma cell line (1994)

In this study, the effect of the synthetic glucocorticoid hormone dexamethasone (DXM) on HSV replication was studied in a DXM receptor-positive mouse neuroblastoma (NB) cell line. In cells treated with 10(-7) M DXM and then infected with HSV, there was a statistically significant 9-18-fold increase in the amount of virus produced in these cells compared to untreated controls. Adsorption kinetic studies with HSV were performed in DXM-treated NB cells and untreated controls. It was found that there was a significant increase in the adsorption rate of HSV in the DXM-treated cells as compared with the controls. During the course of these studies, a strain of NB cells was noted to have lost its ability to stimulate HSV replication following DXM treatment. Receptor binding assays were performed on cytosols prepared from NB cells that responded with an increase in HSV titers to DXM treatment and the new strain of NB cells that was DXM refractile. These latter cells were found to have lost their DXM receptors. These results indicate that the modulation of HSV replication of DXM treated cells was regulated by the presence of DXM receptors in these cells. Once lost, the cells do not respond to DXM treatment with increased HSV replication. These observations may lead to a clinical assay to determine patients with high glucocorticoid levels who may be at risk of recurrent herpes infections.