gebhart/patrepeval huggingface dataset:
Extraction and purification of biologically active metabolites from the Rhodococcus sp. MTM3W5.2 (2018)

Due to an increasing prevalence of bacterial resistance to antibiotic drugs and the overuse of commercial antibiotics, the need to discover novel antibacterial compounds is becoming more urgent. There is one promising avenue of novel drug discovery which has begun to be explored; the analysis of secondary metabolites. Rhodococcus is a genus of gram-positive bacterium known for their ability to catabolize a wide range of compounds, and more notably for its ability to produce bioactive secondary metabolites. Rhodococcus belongs to the class actinobacteria. A species of Rhodococcus, MTM3W5.2, has been discovered in Morristown, Tennessee and was found to produce a metabolite with inhibitory activity against closely related species. The aim of this study is to elucidate the structure of the inhibitory metabolite by first isolating and purifying it, and then characterizing it using spectroscopic techniques. The compound was isolated from MTM3W5.2 RM broth cultures using n-butanol extraction, which yielded an active crude extract. The crude extract was then subjected to fractionation using a Sephedex LH-20 column with a 100% methanol solvent. The inhibitory activity of the fractions was tested through disk diffusion assay using Rhodococcus erythropolis as an indicator of inhibitory activity. Further preparation was completed using preparative reverse-phase high-performance liquid chromatography. Advanced purification was conducted using multiple rounds of analytical reverse-phase HPLC and activity was tested at each subsequent step using disk diffusion assay. Throughout the study, the HPLC fractions were characterized and the stability was monitored using UV-Visible spectroscopy. Two pure samples at 58.63 and 72.72 minutes from HPLC (High-performance liquid chromatography) collections were selected for further structural identification and are currently being studied using spectroscopic techniques, most notably 2D NMR spectroscopy (two-dimensional nuclear magnetic resonance).
An energy-efficient, adaptive voltage scaling output stage for neural stimulators based on SEPIC converter (2016)

This paper presents an energy-efficient output stage for neural simulators which generate needed bi-phasic pulses. Energy efficiency is improved by adopting a single-ended primary inductance converter (SEPIC) that has a wide range of output voltage varying with the stimulus current on tissue load for adaptive voltage scaling. Comparing with a typical current-controlled stimulator which has a fixed high voltage supply, this approach reduces power consumption on the current driver. On-chip compensation is achieved with a Type II compensator while the DC-DC converter is operating in the discontinuous conduction mode (DCM) for reducing power consumption. Voltage-mode control is adopted for its robustness and no need for slope compensation. Measured results indicate that the stimulus current could change from 0.6 mA to 11.8 mA with the step of 0.09 mA when the resistance of tissue is set as 1.5 kΩ and an output range of 0.9 V to 17.8 V with an input voltage of 3.7 V from a li-ion battery is achieved. The SEPIC converter achieves >60% power-conversion efficiency (PCE) when stimulus current was above 2.2 mA and this design can save power by up to 68% compared to the output stage of a typical current-controlled neural stimulator. The circuits have been implemented in a commercially-available 1 μm 40 V BCD process.
High-Performance Nanostructured Supercapacitors on a Sponge (2011)

A simple and scalable method has been developed to fabricate nanostructured MnO2-carbon nanotube (CNT)-sponge hybrid electrodes. A novel supercapacitor, henceforth referred to as "sponge supercapacitor", has been fabricated using these hybrid electrodes with remarkable performance. A specific capacitance of 1,230 F/g (based on the mass of MnO2) can be reached. Capacitors based on CNT-sponge substrates (without MnO2) can be operated even under a high scan rate of 200 V/s, and they exhibit outstanding cycle performance with only 2% degradation after 100,000 cycles under a scan rate of 10 V/s. The MnO2-CNT-sponge supercapacitors show only 4% of degradation after 10,000 cycles at a charge-discharge specific current of 5 A/g. The specific power and energy of the MnO2-CNT-sponge supercapacitors are high with values of 63 kW/kg and 31 Wh/kg, respectively. The attractive performances exhibited by these sponge supercapacitors make them potentially promising candidates for future energy storage systems.
The degradation of intravenously injected chondroitin 4-sulphate in the rat (1973)

The degradation of chondroitin 4-[(35)S]sulphate isolated from chick-embryo cartilage was studied in the rat by experiments on free-range animals, on wholly anaesthetized animals with ureter cannulae, by perfusion of isolated liver, by whole-body radioautography and by isolation of liver lysosomes. After injection into rats 68% of the radioactivity was recovered in the urine after 24h, approximately one-half of this being in the form of low-molecular-weight material, chiefly inorganic sulphate. Cannulation experiments demonstrated that the proportion of low-molecular-weight components excreted in the urine increased with time until, after 12h, virtually all was inorganic sulphate. Whole-body radioautography identified the liver as the major site of radioisotope accumulation after injection of labelled polysaccharide. Perfusion through isolated liver indicated that this organ has the ability to metabolize the polymer with the release of low-molecular-weight products, principally inorganic sulphate. Incubation of a lysosomal fraction prepared from rat liver after injection of chondroitin 4-[(35)S]sulphate gave rise to degradation products of low molecular weight, and experiments in vitro with rat liver lysosomes confirmed that these organelles are capable of the entire degradative process from chondroitin sulphate to free inorganic sulphate.
B-Handy: An Augmented Reality System for Biomechanical Measurement (2022)

The study of bio-mechanics allows us to infer measurements for every day objects without needing measurement tools. A limitation of this comes from the complex mental transformations of space involved. The efficiency of this task degrades the larger these measurements become. We present B-Handy, a system that offloads this mental workload by providing visual transformations of space in the form of tracking and duplicating the user&#x0027;s hand in AR. It is our hope that this system will simplify the complexity of these mental transformations and increase the efficiency of bio-mechanical measurements.
Atmospheric pressure chemical vapor deposition of silicon thin films using cyclohexasilane (2014)

We report the deposition of silicon thin films at high rates using atmospheric pressure chemical vapor deposition (AP-CVD) with cyclohexasilane (CHS), a liquid-hydrosilane. A precursor solution of CHS in cyclooctane was aerosolized and subsequently vaporized prior to contacting with the substrate. Using CHS, Si thin films were obtained at temperatures as low as 300°C. A deposition rate of ~50 nm/s was observed at 500°C; while good-quality Si films were realized at 400°C. Structural analysis of the films indicates a combination of amorphous and nano-crystalline Si phases, withe 2-3 orders of photoconductivity.
A mild and efficient route to Schiff base derivatives of amino acids (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA mild and efficient route to Schiff base derivatives of amino acidsMartin J. O'Donnell and Robin L. PoltCite this: J. Org. Chem. 1982, 47, 13, 2663–2666Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://doi.org/10.1021/jo00134a030RIGHTS & PERMISSIONSArticle Views6980Altmetric-Citations299LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (593 KB) Get e-Alertsclose Get e-Alerts
The relaxed power control algorithm (2017)

With the progress of wireless communication technology, networks become more and more interference limited. One core aspect for guaranteeing required signal qualities in interference limited networks is power control. A simple, yet powerful power control algorithm (PCA) is Yates' iterative standard PCA, which is well known and can be applied to various physical layer technologies. However, for some technologies, e.g., multi-antenna (MIMO) communication systems, its update rules cannot be explicitly calculated, thus rendering the power control problem complicated. For these cases we introduce relaxed PCAs, whose update steps are within certain bounds around that of the standard PCA. We prove that relaxed PCAs and standard PCAs converge to the same fixed points. We apply the introduced algorithm to MIMO wireless networks and develop two manageable power control update rules. We verify their convergence behavior with simulations.
Radioimmunoassay for Cortisol in Pig Saliva and Serum (1997)

An “in-house” radioimmunoassay (RIA) procedure utilizing commercial sources of antiserum and radiolabel was developed for the simultaneous measurement of cortisol in serum and saliva from swine. A commercial RIA kit (Incstar) for cortisol was used to validate the in-house procedure for serum measurements. The correlation coefficient (r) between the Incstar kit and the in-house method for serum cortisol was 0.94. The Incstar kit was modified to accommodate measurement of salivary cortisol concentrations and compared to the in-house procedure. The correlation between these procedures was r = 0.81 and best described by a logarithmic (Ln) curve. Salivary cortisol measures by the in-house RIA were significantly higher than those obtained from the modified Incstar kit (p < 0.01), a probable consequence of the different relative cross-reactions of the respective antisera to cortisone and a dilution effect on the kit standards. Keywords: Radioimmunoassay; salivary cortisol; pigs; stress
Cognitive tasks in information analysis: Use of event dwell time to characterize component activities (2004)

Technology-based enhancement of information analysis requires a detailed understanding of the cognitive tasks involved in the process. The information search and report production tasks of the information analysis process were investigated through evaluation of time-stamped workstation data gathered with custom software. Model tasks simulated the search and production activities, and a sample of actual analyst data were also evaluated. Task event durations were calculated on the basis of millisecond-level time stamps, and distributions were plotted for analysis. The data indicate that task event time shows a cyclic pattern of variation, with shorter event durations (< 2 sec) reflecting information search and filtering, and longer event durations (> 10 sec) reflecting information evaluation. Application of cognitive principles to the interpretation of task event time data provides a basis for developing “cognitive signatures” of complex activities, and can facilitate the development of technology aids for information intensive tasks.
Smart networks for control (1994)

Control networks move small packets of data to a large set of nodes, so as to integrate and automate everything from home appliances to entire factories. This is due to the use of embedded microprocessors. The author discusses the control net architecture, network topology and the fast response of the network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Correction to “Total Synthesis of (−)-Chromodorolide B By a Computationally-Guided Radical Addition/Cyclization/Fragmentation Cascade” (2018)

The structure of L-arabinose (33) in Scheme 3 was incorrect. A correct version of this scheme is shown here. (Figure Presented).
Association of Secretor Status and Recent Norovirus Infection With Gut Microbiome Diversity Metrics in a Veterans Affairs Population (2022)

Norovirus infection causing acute gastroenteritis could lead to adverse effects on the gut microbiome. We assessed the association of microbiome diversity with norovirus infection and secretor status in patients from Veterans Affairs medical centers. Alpha diversity metrics were lower among patients with acute gastroenteritis but were similar for other comparisons.
E-Gun Technology (1981)

Abstract : This program has two main objectives: the first is to develop broad area cathodes which can deliver current densities of 10-20 A/sq cm for several microseconds in duration and for pulse repetition rates of 25 Hz (near term) and up to 100 Hz (long term); the second objective is to develop techniques for foil cooling in the regime somewhat 100 W/sq cm. These techniques include foil materials, both singular and composite structures, active methods of heat removal and support structures which provide good heat conductivity, proper support for the thin foils and high e-beam transmission and efficiency. (JHD)
ChemInform Abstract: Synthetic and Solid‐Form Enablement of Inhalation Candidates (2012)

Abstract Review: 104 refs.
SoC design of Ogg Vorbis decoder using embedded processor (2004)

This paper presents an ARM-based SoC architecture for the Ogg Vorbis audio decoder. A trivial software-based implementation incurs high computational cost and requires high operation frequency. In order to achieve realtime processing and efficient bus interface design for our target system, the load of an embedded processor is reduced through the use of specific hardware for a functional block that has higher computational complexity than other blocks of Ogg Vorbis decoding process. Based on computational cost analysis of whole decoding process, IMDCT (Inverse Modified Discrete Cosine Transform) is detected as the most computation-intensive functional block. As a result of FPGA (Field Programmable Gate Array) implementation, a 48% improvement in execution cycle is achieved by the specific hardware with 3,749 slices.
Adaptive band-partitioning of rinterference cancellation in communications systems (1997)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
Measuring the Physical Properties of Cells (2017)

This chapter examines techniques that measure a wide range of different physical properties of single cells. It considers some future opportunities for microfluidic measurements of single-cell physical properties. The field of microfluidics plays an important role in measuring the physical properties of single cells. Microfluidic devices provide the cell-sized sensitivity, single-cell manipulation, and high throughput necessary for making these measurements. Cell size (mass and volume) and cell density are just three of the cellular physical properties that have been measured in microfluidic devices. The chapter explains how cell mass is measured and also examines a technique that measures the volume of a cell using measurements of cell mass. Unlike Coulter counter measurements of cell volume, a mass-based measurement of cell volume is not affected by the shape or orientation of the cell. The chapter also examines some of the microfluidic Coulter counters.
MEASURING AND PREDICTING EVAPOTRANSPIRATION IN A BANANA SCREENHOUSE (2006)

ISHS III International Symposium on Models for Plant Growth, Environmental Control and Farm Management in Protected Cultivation (HortiModel 2006) MEASURING AND PREDICTING EVAPOTRANSPIRATION IN A BANANA SCREENHOUSE
Bridging strategy between microscopic and macroscopic crack growth simulations to predict fatigue strength of steels (2022)

A strategy for bridging microscopic and macroscopic crack-growth simulations is proposed for efficiently and accurately predicting the fatigue strength of steels by integrating the multiscale model and the concept of the bridging method. Validation by comparing the experimental results of macro-crack specimens and the numerical results of the multiscale model shows a reduction of more than 90% in the numerical costs with the proposed strategy compared to the multiscale model. Only 4.2% and 2.7% errors in fatigue life for the two macro-crack specimens under the maximum loading cases are achieved, whereas no errors in fatigue limits are observed using the proposed strategy, compared to the multiscale model. The accuracy and efficiency of predicted results indicate that the proposed strategy can serve as a robust foundation for evaluating the fatigue failure behaviour of thick components/structures in engineering applications.
Rare cyano glucosides from Coldenia procumbens Linn (2013)

The objective of the work was to isolate active phytoconstituents present in the herb Coldenia procumbens. Phytochemical investigation of the aerial parts of the plant yielded rare Nitrile glucosides, Ehretioside A1 1 and Lithospermoside (Griflonin) 2. The structures of the compounds were established on the basis of various NMR and Mass spectral data. The cyano-containing compounds 1 and 2 were isolated for the first time from C. procumbens.
Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. (1994)

The synaptic vesicle membrane protein VAMP (vesicle-associated membrane protein or synaptobrevin) has been implicated in synaptic vesicle docking and fusion. Synaptophsin (p38), also a synaptic vesicle membrane protein, has four transmembrane domains and may function as a gap junction-like pore or channel. Here we report evidence for a direct interaction between VAMP and synaptophysin using chemical cross-linking followed by the identification of immunoreactive protein complexes. A prominent complex of 56 kDa was found to consist of VAMP and synaptophysin. Furthermore, we demonstrate that this VAMP-synaptophysin complex is enriched in the synaptic vesicle fraction of rat brain, is independent of detergent solubilization, and is present in PC12 cells subjected to in vivo cross-linking.
Passenger Lymphocyte Syndrome After Pediatric Liver Transplantation (2019)

We report a 14% prevalence of PLS following pediatric ABO-c LT. Recipient blood group A+ receiving a donor O+ graft is a risk factor for PLS. Recognition of PLS as a cause of early acute anemia in pediatric ABO-c LT enables timely transfusion with donor (rather than recipient) blood group red cells.
A collaborative, academic approach to optimizing the national clinical research infrastructure: The first year of the Trial Innovation Network (2018)

Inefficiencies in the national clinical research infrastructure have been apparent for decades. The National Center for Advancing Translational Science (NCATS) -sponsored CTSA program is able to address such inefficiencies. The Trial Innovation Network (TIN) is a collaborative initiative with the CTSA Program and other NIH Institutes and Centers (ICs) that addresses critical roadblocks to accelerate the translation of novel interventions to clinical practice. The TIN's mission is to execute high quality trials in a quick, cost-efficient manner. The TIN awardees are composed of: three Trial Innovation Centers (TICs), the Recruitment Innovation Center (RIC), and the individual CTSA institutions that have identified TIN Liaison units. The TIN has launched a national scale single (central) IRB system, master contracting agreements, quality-by-design approaches, novel recruitment support methods, and applies evidence-based strategies to recruitment and patient engagement. The TIN has received 113 submissions from 39 different CTSA institutions and 8 non-CTSA Institutions, with projects associated with 12 different NIH ICs across a wide range of clinical/disease areas. Already more than <b>150</b> unique health systems/organizations are involved as sites in TIN related multisite studies. The TIN will begin to capture data and metrics that quantify increased efficiency and quality improvement during operations.
The Function of myo‐Inositol in the Biosynthesis of Raffinose (1973)

1. An enzyme from Vicia faba seeds is described which transfers the galactosyl moiety of galactinol to sucrose giving rise to raffinose and myo ‐inositol. 2. The enzyme was purified about 400‐fold through 6 steps. A molecular weight of 80000 has been determined by gel‐filtration and of 100000 by glycerol density gradient centrifugation. 3. The enzyme galactinol:sucrose 6‐galactosyl transferase is different from α‐galactosidase; these two activities as well as the stachyose‐synthesizing enzyme separate during purification. 4. The transferase showed a high acceptor specificity. Out of 10 acceptors tested a transfer only to sucrose took place. This transfer was 5 times faster than the hydrolysis of galctinol. Galactinol, p ‐nitrophenyl‐α‐ d ‐galactopyranoside and raffinose, but not UDP‐galactose, could act as donors. 5. The enzyme catalyzes an exchange reaction between raffinose and [ 14 C]sucrose. This partial reaction is less sensitive towards heat inactivation and SH‐poisons than the total reaction. 6. The pH‐optimum of the reaction was found to be pH 7.0, the temperature optimum 42 °C. Heat inactivation could be prevented to some extent by galactinol and raffinose. In the presence of 0.4 mM sucrose the K m ‐value for galactinol was 7 mM and for raffinose 10 mM. For sucrose a K m ‐value of 1 mM in the synthesis reaction has been determined. 7. The transferase activity is high enough to explain the synthesis rate in vivo of all the raffinose‐type sugars present in the seeds. 8. The physiological meaning of the results as well as the metabolic function of myo ‐inositol is discussed.
Detection of Breast Malignancy: Diagnostic MR Protocol for Improved Specificity (2004)

The combined MR protocol of DCE MR imaging, 1H MR spectroscopy, and perfusion MR imaging has high sensitivity and specificity in the diagnosis of breast cancer.
Associative access to data in holographic memories with controlled transparencies (1978)

An experimental study was made of an associative holographic memory with a controlled phase transparency for the formation of an orthogonal set of key words. When a system of the Walsh functions was used as key words, the experimental signal/search-noise ratio amounted on the average to 150. The functional potentialities, structure, and ways of realization of such a memory were considered, as well as the organization of various algorithms for processing of the key-word coincidence signals.
Spatial variation decomposition via sparse regression (2012)

In this paper, we briefly discuss the recent development of a novel sparse regression technique that aims to accurately decompose process variation into two different components: (1) spatially correlated variation, and (2) uncorrelated random variation. Such variation decomposition is important to identify systematic variation patterns at wafer and/or chip level for process modeling, control and diagnosis. We demonstrate that the spatially correlated variation can be accurately represented by the linear combination of a small number of “templates”. Based upon this observation, an efficient algorithm is developed to accurately separate spatially correlated variation from uncorrelated random variation. Several examples based on silicon measurement data demonstrate that the aforementioned sparse regression technique can capture systematic variation patterns with high accuracy.