gebhart/patrepeval huggingface dataset:
Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II (2006)

The conserved oligomeric Golgi (COG) complex is a heterooctameric complex that regulates intraGolgi trafficking and the integrity of the Golgi compartment in eukaryotic cells. Here, we describe a patient with a mild form of congenital disorder of glycosylation type II (CDG-II) that is caused by a deficiency in the Cog1 subunit of the complex. This patient has a defect in both N- and O-glycosylation. Mass spectrometric analysis of the structures of the N-linked glycans released from glycoproteins from the patient's serum revealed a reduction in sialic acid and galactose residues. Peanut agglutinin (PNA) lectin staining revealed a decrease in sialic acids on core 1 mucin type O-glycans, indicating a combined defect in N- and O-glycosylation. Sequence analysis of the COG1 cDNA and gene identified a homozygous insertion of a single nucleotide (2659-2660insC), which is predicted to lead to a premature translation stop and truncation of the C terminus of the Cog1 protein by 80 amino acids. This mutation destabilizes several other COG subunits and alters their subcellular localization and hence the overall integrity of the COG complex. This results in reduced levels and/or altered Golgi localization of alpha-mannosidase II and beta-1,4 galactosyltransferase I, which links it to the glycosylation deficiency. Transfection of primary fibroblasts of this patient with the full length hemagglutinin-tagged Cog1 indeed restored beta-1,4 galactosyltransferase Golgi localization. We propose naming this disorder CDG-II/Cog1, or CDG-II caused by Cog1 deficiency.
An Intrusion-Tolerant and Self-Recoverable Network Service System Using A Security Enhanced Chip Multiprocessor (2005)

This paper proposes a novel system design using a chip multiprocessor (CMP) to provide intrusion tolerance and self-recovery for server applications. Our platform provides three major advantages over previously proposed approaches, 1) security insulation from remote exploits and attacks; 2) close coupling between processor cores in a CMP to ensure immediate logging, fine-grained inspection and fast recovery; 3) concurrent and fine-grained inspection, logging and recovery techniques that are off of the critical path. We have designed a multi-point defense and recovery system to defeat remote exploits. We used a checkpoint based approach to recover server applications under attack. It takes a snapshot of the application’s context and memory state before it handles the next request. If the request turns out to be malicious, the system can discard the malicious request and rollback the application’s state to a known good one through checkpointing. We have also designed an rapid recovery system for kernel space rootkit attacks. Our intrusion survivable and self-recovery design provides reliable production services that System Administrators are seeking.
Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153) (1996)

The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect the function of the endoplasmic reticulum (ER). Because of the pleiotropic effects of such agents on other cellular processes, the role of ER stress in inducing CHOP gene expression has remained unclear. We find that cells with conditional (temperature-sensitive) defects in protein glycosylation (CHO K12 and BHK tsBN7) induce CHOP when cultured at the nonpermissive temperature. In addition, cells that are defective in initiating the ER stress response, because of overexpression of an exogenous ER chaperone, BiP/GRP78, exhibit attenuated inducibility of CHOP. Surprisingly, attenuated induction of CHOP was also noted in BiP-overexpressing cells treated with methyl methanesulfonate, an agent thought to activate CHOP by causing DNA damage. The roles of DNA damage and growth arrest in the induction of CHOP were therefore reexamined. Induction of growth arrest by culture to confluence or treatment with the enzymatic inhibitor N-(phosphonacetyl)-L-aspartate did not induce CHOP. Furthermore, both a DNA-damage-causing nucleoside analog (5-hydroxymethyl-2'-deoxyuridine) and UV light alone did not induce CHOP. These results suggest that CHOP is more responsive to ER stress than to growth arrest or DNA damage and indicate a potential role for CHOP in linking stress in the ER to alterations in gene expression.
Art and technology in interface devices (2005)

This paper presents work carried out for a project to develop interface devices for haptics that includes finger/hand manipulation, locomotion. It is well known that sense of touch is inevitable for understanding the real world. The last decade has seen significant advance in development of haptic interface. However, methods for implementation of haptic devices are still in try-and-error. Compared to visual and auditory displays, haptic display has not been used in everyday life. In order to overcome this limitation, we have been exhibiting the interface devices as art work. This paper introduces issues and solutions in haptic device through 18-years history of our research activities.
ChemInform Abstract: THE STEVENS REARRANGEMENT OF N1‐SULFONIUM SALTS OF HYDANTOIN (1978)

Abstract Die Chlorhydantoine (I) reagieren mit den Sulfiden (II) zu den Sulfoniumchloriden (III), die zur Charakterisierung in die stabileren Hexachloroantimonate (IV) übergeführt werden.
Schaum's outline of theory and problems of state space and linear systems (1971)

Schaum's outline of theory and problems of state space and linear systems , Schaum's outline of theory and problems of state space and linear systems , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Outcome improvement of glaucoma filtration surgery through the effect of local rock‐inhibition on wound healing (2012)

Abstract Purpose The aim of this study was to investigate the efficacy of a local ROCK‐inhibitor; AMA0076 (Amakem NV) for improving surgical outcome, after glaucoma filtration surgery in a rabbit model. Methods The in vivo effects of local ROCK‐inhibition were investigated in a rabbit model of glaucoma filtration surgery (n=5 per histological analysis group). Topical treatment with AMA0076 (study eye) and vehicle (control eye) was administered every day 3x/day (9h/13h/17h) from day 1 after surgery. Treatment outcome was studied by clinical investigation (IOP; intraocular pressure, bleb area and bleb survival) as well as immunohistological analyses for inflammation (CD45), angiogenesis (CD31) and collagen deposition (Sirius Red) at day 3, 8 and 14 after surgery. Results Bleb survival showed no difference between treated and non‐treated eyes however, there a trend (p=0,09) can be distinguished. Topical treatment of AMA0076 reduced inflammation on day 3 (p=0.036) and day 8 (p=0.044) as well as angiogenesis on day 8 (p=0.04). There were no differences in collagen deposition. Conclusion Targeting ROCK with a local ROCK inhibitor, AMA0076, is efficacious in reducing inflammation and angiogenesis on several time points in a rabbit model of glaucoma surgery. These results render ROCK an interesting target to increase the success rate of filtration surgery and point to potential therapeutic benefits of the local ROCK inhibitor, AMA0076.
A low-power TCAM design using mask-aware match-line (MAML) technique (2011)

The ternary content addressable memory (TCAM) is widely used in the network router to speed up the forwarding table lookup, but it usually consumes a large amount of power. This paper introduces a low-power TCAM design, in which we propose the mask-aware match-line (MAML) technique to reduce the TCAM power dissipated in the match-line (ML) switching activity. Depending on the mask data, the MAML design can prevent the entire ML from being charged/discharged during the search operation, such that the average ML power consumption can be reduced effectively. For a 256´128-bit IPv6 TCAM array, based on TSMC 0.18mm technology the simulation results show that the refined MAML design with the granularity of 32 can achieve 58% ML energy reduction compared to the conventional TCAM design, and the search performance improvement is about 25%.
Short Packets Over Block-Memoryless Fading Channels: Pilot-Assisted or Noncoherent Transmission? (2018)

We present nonasymptotic upper and lower bounds on the maximum coding rate achievable when transmitting short packets over a Rician memoryless block-fading channel for a given requirement on the packet error probability. We focus on the practically relevant scenario in which there is no a priori channel state information available at the transmitter or at the receiver. An upper bound built upon the min-max converse is compared with two lower bounds: the first one relies on a noncoherent transmission strategy in which the fading channel is not estimated explicitly at the receiver and the second one employs pilot-assisted transmission (PAT) followed by maximum-likelihood channel estimation and scaled mismatched nearest-neighbor decoding at the receiver. Our bounds are tight enough to unveil the optimum number of diversity branches that a packet should span so that the energy per bit required to achieve a target packet error probability is minimized, for a given constraint on the code rate and the packet size. Furthermore, the bounds reveal that noncoherent transmission is more energy efficient than PAT, even when the number of pilot symbols and their power is optimized. For example, in Rayleigh fading, for the case when a coded packet of 168 symbols is transmitted using a channel code of rate 0.48-bits/channel use, over a block-fading channel with block size equal to eight symbols, PAT requires an additional 1.2 dB of energy per information bit to achieve a packet error probability of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> compared with a suitably designed noncoherent transmission scheme. Finally, we devise a PAT scheme based on punctured tail-biting quasi-cyclic codes and ordered-statistics decoding, whose performance is close (1-dB gap at 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> packet error probability) to the ones predicted by our PAT lower bound. This shows that the PAT lower bound provides useful guidelines on the design of actual PAT schemes.
Compressive sensing with frequency warped compensation for damage detection in composite plate (2013)

This work focuses on an ultrasonic guided wave structural health monitoring (SHM) system development for composite plate inspection. The development of an in situ health monitoring system that can inspect large areas and communicate remotely to the inspector is highly computational demanding due to both the huge number of piezoelectric sensors needed and the high sampling frequency. To address this problem, a general approach for low rate sampling is developed. Compressive Sensing (CS) has emerged as a potentially viable technique for the efficient acquisition that exploits the sparse representation of dispersive ultrasonic guided waves in the frequency warped basis. The framework is applied to lower the sampling frequency and to enhance defect localization performances of Lamb wave inspection systems. As a result, an automatic detection procedure to locate defect-induced reflections was demonstrated and successfully tested on simulated Lamb waves propagating in a carbon fiber plate using PZFlex software. The proposed method is suitable for defect detection and can be easily implemented for real application to structural health monitoring.
Engine Fault Analysis: Part II---Parameter Estimation Approach (1985)

The general fault analysis problem can be divided into two parts: fault detection and diagnosis (location). Fourier series, autocorrelation, and other techniques have been used for fault detection. However, these approaches cannot be utilized for locating the faults. In this paper a methodology is presented to locate faulty cylinder(s). The procedure involves the development of a mathematical model of the engine dynamics. This model takes into consideration the cylinder gas pressure, engine inertia, and load. The resultant torque is computed by using parameter estimation techniques. The parameter estimation technique employed can determine time-varying parameters without prior knowledge of the structure of the parameter. In the problem at hand, this is an important requirement. The resultant torque is the net of the cylinder gas torque and the frictional torque. The model and the estimation procedure have been verified by performing tests on a single-cylinder engine. A discriminant function has been defined to classify the performance of each cylinder. Our results indicate that the amplitude of the resultant torque can be used to identify the faulty cylinder(s). We have verified this approach by tests and studies on a six-cylinder engine. In our experiments we have studied cases involving one or two faulty cylinders.
Assignment of the human tyrosine hydroxylase gene to chromosome 11 (1984)

Using a panel of human-mouse somatic cell hydrids and a cDNA probe for human tyrosine hydroxylase, we have assigned the structural gene for tyrosine hydroxylase to chromosome 11 by Southern blotting techniques.
A VLSI Design for Implementation of TransformDomain Adaptive Filters (1996)

A VLSI implementation of a dedicated digital signal processor is presented. The processor is tailored for efficient implementation of transform domain adaptive filters. It incorporates a butterfly processor which performs butterfly operation to implement the required transformation. It is also able to perform complex addition, subtraction and multiplication. The butterfly processor makes use of a redundant binary tree multiplier with a recently proposed coding of signed‐digit numbers which reduces the number of levels in the tree by one. An on‐chip read only memory holds the transformation coefficients. The contents of the ROM determine the type of transform. The processor incorporates an ALU to perform integer arithmetic, address calculations and implementation of circular memory scheme. For fastest accessibility, the essential variables of the algorithm are implemented in a register fire.
Analysis of environmental regulations governing the disposal of geothermal wastes in California (1985)

Federal and California regulations governing the disposal of sludges and liquid wastes associated with the production of electricity from geothermal resources were evaluated. Current disposal practices, near/far term disposal requirements, and the potential for alternate disposal methods or beneficial uses for these materials were determined. 36 refs., 3 figs., 15 tabs. (ACR)
Fabrication of metal-oxide-free CH3NH3PbI3perovskite solar cells processed at low temperature (2015)

Efficient, metal-oxide-free perovskite solar cells were successfully developed by employing the N–I–P architecture based on the modified solvent engineering process, exhibiting a PCE of 15.3%.
Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion (2014)

T cell exhaustion is thought to be a natural mechanism for limiting immune pathology, although it may be desirable to circumvent this mechanism to help eliminate viral reservoirs or tumors. Although there are no definitive markers, a fingerprint for exhausted T cells has been described that includes the transmembrane proteins PD-1, LAG3, and Tim-3. However, apart from the recruitment of tyrosine phosphatases to PD-1, little is known about the biochemical mechanisms by which these proteins contribute to the development or maintenance of exhaustion. Tim-3 contains no known motifs for the recruitment of inhibitory phosphatases, but it may actually increase signaling downstream of TCR/CD3, at least under acute conditions. Other studies showed that T cell exhaustion results from chronic stimulation that extends the effector phase of T cell activation, at the expense of T cell memory. We suggest that Tim-3 may contribute to T cell exhaustion by enhancing TCR-signaling pathways.
Abolishing HIV-1 infectivity using a polypurine tract-specific G-quadruplex-forming oligonucleotide (2016)

Since ODN A efficiently inactivates HIV-1 and also displays high stability and resistance against semen, it combines unique and promising features for its further development as a vaginal microbicide against HIV.
Vadadustat for treatment of anemia in patients with dialysis-dependent chronic kidney disease receiving peritoneal dialysis (2023)

In the subgroup of patients receiving peritoneal dialysis in the phase 3 INNO2VATE trials, safety and efficacy of vadadustat were similar to darbepoetin alfa.
Improvement of efficiency and color purity utilizing two-step energy transfer for red organic light-emitting devices (2002)

We present organic red light-emitting devices with improved optical and electrical characteristics utilizing the two-step energy transfer. N,N′-diphenyl-N,N′-bis(1-naphthyl)-(1,1′-biphenyl)-4,4′-diamine and tris-(8-hydroxyquinoline) aluminum (Alq) are used as hole and electron-transporting layers, respectively. Quinacridone (QAD) and 4-(dicyanomethylene)-2-t- butyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB) are codoped into the Alq emitting layer. Compared with devices where the emitting layer is only composed of Alq and DCJTB, the emitting characteristics such as emission efficiency and purity of emission color are greatly improved, and the turn-on voltage is decreased as much as 4 V. We attribute these improvements to the assistant dopant (QAD), which leads to the more efficient energy transfer from Alq to DCJTB.
Carbon dioxide fluxes across the air-water interface and its impact on carbon availability in aquatic systems (1995)

Diffusion of CO2 across the air-water interface was analyzed with a model that simulates both transport and reaction of CO2 in a stagnant boundary layer. The atmospheric C influx was determined in relation to several environmental variables: pH, total dissolved inorganic C, temperature, and the thickness of the stagnant boundary layer in relation to ambient windspeed. We used the model to calculate the atmospheric CO2 influx into six experimental ditches for a period of 6 or 8 months, starting in early spring. Three of the six ditches were dominated by aquatic macrophytes and three by benthic algae. Each series received three levels of external N and P input. A comparison with net C assimilation during the same period, as estimated from continuous oxygen measurements, showed that, especially in the ditches dominated by submersed macrophytes, a sizable fraction of the C requirements during this period could have been obtained from atmospheric CO2. In the ditches dominated by benthic algae, this fraction was considerably less, but nonetheless substantial, and was related to the level of N and P loading. Increased primary production due to enhanced external N and P loading increased the atmospheric C input due to the resultant higher pH values. The trophic state with respect to N and P and the availability of C are therefore interrelated.
Metal Complexes with Macrocyclic Ligands Part XXX. Synthesis and structure of halocuprates of tetraprotonated 1,4,8,11‐tetraazacyclotetradecane and its Cu2+ complex (1989)

Abstract By mixing acidic solutions of 1,4,8,11‐tetraazacyclotetradecane (Cy) with CuX 2 (X = Cl − , Br − ), either the hexahalocuprates of the tetraprotonated form of the macrocycle ([CyH 4 ] [CuX 6 ]) or the tetrahalocuprates of its Cu 2+ complex ([CuCy] [CuX 4 ]) are obtained. The structures of the chloro derivatives are established by X‐ray diffraction analysis. In [CyH 4 ] [CuCl 6 ], the Cu 2+ is in a tetragonally distorted octahedral geometry with four short and two long CuCl bonds. The tetraprotonated macrocycle is centrosymmetric, and its conformation is exodentate, so that the four ammonium groups are as far as possible from each other to minimize the electrostatic repulsion. In [CuCy] [CuCl 4 ], the Cu 2+ ion complexed by the macrocycle is surrounded by four N‐atoms in a square‐planar arrangement. In addition, the axial positions are occupied by two Cl − ions of two CuCl units, which act as bridges. The macrocycle is in the trans ‐ III ‐configuration. The other Cu 2+ ion is coordinated by four Cl − ions in a distorted tetrahedral geometry. IR and VIS spectra of the chloro and bromo derivatives are used to discuss the structure of the bromo species.
Reactive melt blending of low-density polyethylene with poly (acrylic acid) (2011)

Reactive melt blending of low-density polyethylene LDPE with a low molecular weight poly (acrylic acid) PAA in the presence of benzoyl peroxide (BPO) free radical initiator was studied by means of a HAAKE torque rheometer and a capillary rheometer FTIR spectroscopy and was used to characterize the structure of LDPE/PAA blends. The rheological behavior of blends has been investigated at different temperatures (170, 190, 210 and 230 °C) and shear rates (5.43, 18.1, 54.3, 181 and 543 S−1). With a rise of temperature and increasing shear rates the shear stress of blends increases nonlinearly. The melt viscosity increases with the increase in the PAA proportion but decreases with the increasing shear rate and shear stress. The melts of all the blends are pseudoplastic in nature. The flow behavior index (n) of the blends decreases with the increase in the PAA proportion and with the increase in the temperature. The temperature sensitivity of the flow behavior of the blends is studied using Arrhenius plots. The system exhibits relatively low activation energy which means less sensitivity to temperature with an increase in the PAA ratio.
ChemInform Abstract: D2‐Symmetric Dirhodium Catalyst Derived from a 1,2,2‐Triarylcyclopropanecarboxylate Ligand: Design, Synthesis and Application. (2012)

Abstract The new rhodium catalyst (I) is prepared and highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and a combined C—H functionalization/Cope rearrangement are achieved using this catalyst.
Decision Trees for Uplift Modeling (2010)

Most classification approaches aim at achieving high prediction accuracy on a given dataset. However, in most practical cases, some action, such as mailing an offer or treating a patient, is to be taken on the classified objects and we should model not the class probabilities themselves, but instead, the change in class probabilities caused by the action. The action should then be performed on those objects for which it will be most profitable. This problem is known as uplift modeling, differential response analysis or true lift modeling, but has received very little attention in Machine Learning literature. In the paper we present a tree based classifier tailored specifically to this task. To this end, we design new splitting criteria and pruning methods. The experiments confirm the usefulness of the proposed approach and show significant improvement over previous uplift modeling techniques.
Structure from two orthographic views of rigid motion (1989)

We study the inference of rigid three-dimensional interpretations for the structure and motion of four or more moving points from but two orthographic views of the points. We develop an algorithm to determine whether image data are compatible with a rigid interpretation. As a corollary of this result we find that the measure of false targets (roughly, nonrigid objects that appear rigid) is zero. We find that if the two views have at least one rigid interpretation, then in fact there is a canonical one-parameter family of rigid interpretations; we show how to compute this family, and we describe precisely how the rigid interpretations vary within it. Since only two views are used, this analysis is relevant also to stereo vision.