gebhart/patrepeval huggingface dataset:
ON SOME POSSIBILITIES OF PROTECTING CELLS FROM DAMAGING EFFECTS OF ULTRAVIOLET IRRADIATION (1964)

Abstract. The possibility of increasing the cell resistance to short‐wave u. v. rays has been investigated with some chemicals. Ciliated epithelium cells of gills of pearly mussel Unio crassus Phillipsson have been shown to become more resistant after treatment with 0 . 25–0.50 per cent solutions of calcium chloride during 24 hr or by 0.001– 0.001 per cent solutions of 2‐benzyl‐benzimidazole during 3–7 days or by 0.0001 per cent solution of 5–6‐di‐methyl‐benzimidazole during 7 days. When irradiated with u. v. light (λ=2537 Å) these cells survive for a longer time than irradiated control cells.
An algorithm for planning jointing of lines in an optical distribution network (2000)

A method of determining the most effective way to joint lines in an optical distribution network is needed, because of the high cost of jointing optical-fiber lines compared to lines in a metallic network and because of the limitation on the number of joints. In this paper, I model the joint form planning problem as an optimization problem, and propose an algorithm that can solve it effectively. This algorithm can determine the optimum joint form even for a large-scale network. © 2000 Scripta Technica, Electron Comm Jpn Pt 1, 84(2): 39–50, 2001
Fabrication of ridge waveguides in LiNbO 3 thin film crystal by proton-exchange accelerated etching (2009)

A simple fabrication method of adhered LiNbO3 ridge waveguides by accelerated etching of the proton-exchanged region is proposed and demonstrated. The waveguides were fabricated and tested at 1.55 µm wavelength. Strongly confined guided modes were obtained. The waveguides are suitable for efficient nonlinear-optic wavelength conversion devices.
Realtime multiprocessor for mobile ad hoc networks (2008)

Abstract. This paper introduces a real-time Multiprocessor System-On-Chip (MPSoC) for low power wireless applications. The multiprocessor is based on eight 32bit RISC processors that are connected via an Network-On-Chip (NoC). The NoC follows a novel approach with guaranteed bandwidth to the application that meets hard realtime requirements. At a clock frequency of 100 MHz the total power consumption of the MPSoC that has been fabricated in 180 nm UMC standard cell technology is 772 mW.
The new anti-epileptic drugs: A clinical profile. (1999)

Full text is available as a scanned copy of the original print version.
Detecting Rheumatic Arthritis by Artificial Intelligent Multi-Parameter Classifications of Optical Tomographic Images (2008)

We demonstrate that sensitivity and specificity in detecting rheumatoid arthritis from optical tomographic images can be greatly increased when an artificial intelligent multi-parameter classifications method, called Self-Organizing Mapping (SOM), is used.
Coupled in vivo activity of creatine phosphokinase and the membrane-bound (Na+,K+)-ATPase in the resting and stimulated electric organ of the electric fish Narcine brasiliensis (1991)

Physiological control of the plasma membrane sodium pump, (Na+,K+)-ATPase, is essential for proper function of eukaryotic cells. In the electric organ of the elasmobranch Narcine brasiliensis, the normal demands placed upon the pump during the process of generation of electrical currents call for large and rapid changes in activity of this enzyme, making this a good model for the study of its cellular regulation. 31P NMR spectroscopic techniques were used to study metabolic regulation of membrane pump function in resting and stimulated electric organ and in skeletal muscle of the live, intact N. brasiliensis. Because the ATP synthetic abilities of the electric organ by glycolysis or oxidative phosphorylation are extremely limited, depletion of phosphocreatinine (PCr) could be used to determine the activity of the (Na+,K+)-ATPase after the electric organ was stimulated to discharge, and to measure the net flux from PCr to ATP through the creatine phosphokinase (CPK) reaction in the electric organ. Saturation transfer, an NMR technique which measures exchange rates, was applied to determine the unidirectional flux in the forward direction through the same reaction in the electric organ and in skeletal muscle as a control. The pseudo first-order rate constant kf for the CPK reaction at 24 degrees C in resting electric organ was 0.000 +/- 0.002 s-1 (n = 10) and in skeletal muscle was 0.08 +/- 0.03 s-1 (n = 3). The results demonstrate that in resting electric organ, which is well supplied with CPK, there was no measurable flux through this reaction, although CPK when extracted is highly active. Measured and calculated levels of all substrates for the creatine kinase reaction in the electric organ are similar to those in unstimulated skeletal muscle, where the creatine phosphokinase reaction rates are high in vivo. In contrast to the resting electric organ, during stimulation of the electric organ the measured net rate constant was greater than 0.08 s-1. In addition, as shown by lack of PCr depletion, there was virtually no net turnover of ATP in the resting organ compared to the stimulated organ. The marked difference in the (Na+,K+)-ATPase activity in the resting and activated electric organ confirmed earlier results (Blum, H., Nioka, S., and Johnson, R. G., Jr. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 1247-1251). Together, these results suggest that there is a novel method of coordinate regulation of cellular enzymes of great sensitivity and rapidity.
Self-Assembly of Peptide Nanotubes in an Organic Solvent (2008)

The self-assembly of a modified fragment of the amyloid beta peptide, based on sequence Abeta(16-20), KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into peptide nanotubes is observed, as confirmed by electron microscopy and small-angle X-ray scattering. The secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving beta-sheet self-assembly. The beta-sheets wrap helically to form the nanotubes, the nanotube wall comprising four wrapped beta-sheets. At higher concentration, the peptide nanotubes form a nematic phase that exhibits spontaneous flow alignment as observed by small-angle neutron scattering.
Neuronale Netze zur multiparametrischen Diagnostik experimenteller Maus-Colitiden (2017)

MRT ermöglicht bei chronisch-entzündlichen Darmerkrankungen die nichtinvasive Erfassung pathologischer Veränderungen der betroffenen Darmabschnitte. Neben morphologischen Veränderungen können im MRT auch Relaxationszeiten und Diffusionskapazität der Darmwand zur Colitisdiagnostik verwendet werden. Ziel der Studie war die multiparametrische Bildgebung experimenteller Colitiden im Mausmodell unter Zuhilfenahme Neuronaler Netze (NN), um Sensitivitäten und Spezifitäten in der Colitisdiagnostik zu optimieren.
LOCALIZATION METHOD FOR LOW POWER CONSUMPTION SYSTEMS (2011)

Locating nodes is a fundamental problem in wireless networks with hundreds of devices deployed in a wide&#13;\narea. This is especially relevant for mobile nodes. Wireless sensor nodes are usually powered by small&#13;\nbatteries, solar panels or piezoelectric generators, so that, and consequently, power consumption is the main&#13;\nconstraint to deal with. But classic localization techniques do not consider the problem of energy consumption&#13;\nas a key point. This paper presents a novel low power and range-free localization technique based on&#13;\ndistributed fuzzy logic and cooperative processing among a set of fixed nodes and its neighbours. This feature&#13;\npermits better accuracy with less power consumption than most relevant localization techniques
Amyotrophic Lateral Sclerosis with IgM Antibody against Gangliosides GM2 and GD2 (2003)

We report a case of amyotrophic lateral sclerosis (ALS) with IgM antibody against gangliosides GM2 and GD2. A 57-year-old woman presented with slowly progressive muscular weakness of the upper extremities and dysarthria. She fulfilled the clinical and electrophysiological criteria of ALS, and died from sudden suffocation about 3 years after the onset of illness. The patient's serum IgM antibody was shown to recognize the structure shared by GM2 and GD2. Since anti-GM2 antibodies have been implicated in motor neuropathy or motor neuron syndrome, this rare case might contribute to the understanding of the immunological aspects of ALS.
Development of distributed generation infrastructure for microgrid connectivity to operational power systems (2010)

Distributed Generation (DG) from alternate sources and smart grid technologies represent good solutions for the increase in energy demands. Employment of these DG assets requires solutions for the new technical challenges that are accompanied by the integration and interconnection into operational power systems. A DG infrastructure comprised of alternate energy sources in addition to conventional sources, is developed as a test bed. The test bed is operated by synchronizing, wind, photovoltaic, fuel cell, micro generator and energy storage assets, in addition to standard AC generators. Connectivity of these DG assets is tested for viability and for their operational characteristics. The control and communication layers for dynamic operations are developed to improve the connectivity of alternates to the power system. A real time application for the operation of alternate sources in microgrids is developed. Multi agent approach is utilized to improve stability and sequences of actions for black start are implemented. Experiments for control and stability issues related to dynamic operation under load conditions have been conducted and verified.
Co-designed accelerator for homomorphic encryption applications (2018)

Fully Homomorphic Encryption (FHE) is considered as a key cryptographic tool in building a secure cloud computing environment since it allows computing arbitrary functions directly on encrypted data. However, existing FHE implementations remain impractical due to very high time and resource costs. These costs are essentially due to the computationally intensive modular polynomial multiplication. In this paper, we present a software/hardware co-designed modular polynomial multiplier in order to accelerate homomorphic schemes. The hardware part is implemented through a High-Level Synthesis (HLS) flow. Experimental results show competitive latencies when compared with handmade designs, while maintaining large advantages on resources. Moreover, we show that our high-level description can be easily configured with different parameters and very large sizes in negligible time, generating new designs for numerous applications.
Development of Novel Delta Opioid Receptor Inverse Agonists and Their Antitussive Effects (2018)

We synthesized a delta opioid receptor (DOR) antagonist naltrindole (NTI) derivative SYK-165 with a 2,2,2-trifluoroethyl substitute on the 17-nitrogen and reported it showed DOR partial inverse agonist activity in [35S] GTPγS binding assays (Bioorg. Med. Chem. Lett., 2015, 25, 2927-2930.). For the purpose of investigating the further structure-activity relationship, we designed and synthesized NTI derivatives with various electron-withdrawing groups at the 17-position to find a DOR full inverse agonist SYK-623, possessing a 17-cyclopropanecarbonyl group. SYK-623 was over 100-fold more potent than ICI-174,864, a standard DOR inverse agonist. We applied such modification to other DOR antagonists, 7-benzylidenenaltrexone (BNTX) and naltriben (NTB), which have respective chemotypes different from that of NTI. As a result, 17-cyclopropanecarbonyl derivatives SYK-723 (BNTX type) and SYK-724 (NTB type) were also potent DOR full inverse agonists. SYK-623, SYK-723, and SYK-724 are very interesting compounds because these compounds elicited potent DOR full inverse agonist activities in spite of the fact that they have no basic nitrogen, which is known to be indispensable functionality for the interaction with the opioid receptors.
Vitamin D analogs and coactivators. (2006)

The secosteroid hormone 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has potent antiproliferative and prodifferentiating actions on a wide variety of normal as well as malignant cell types. Strong calcemic effects obstruct the actual application of 1,25-(OH)2D3 for the treatment of hyperproliferative disorders such as cancer. To overcome this problem, structural analogs of 1,25-(OH)2D3 have been designed with a clear dissociation between antiproliferative and calcemic effects. This review focuses on the molecular mode of action of different 1,25-(OH)2D3 analogs and, in particular, on the recruitment of cofactor molecules to the vitamin D receptor by these analogs.
Auditory Impairments in HIV-Infected Children (2016)

As expected, children with HIV+ were more likely to have a history of ear drainage, and to have abnormal tympanograms. Similar to the adult findings, the HIV+ group did not show significantly reduced audiometric thresholds, but did have significantly lower DPOAE magnitudes. These data suggest that (1) HIV+ children often have middle ear damage which complicates understanding the direct effects of HIV on the hearing system, and (2) even when corrected for confounders DPOAEs were lower in the HIV+ group. Previous studies suggest ototoxicity from antiretroviral drugs is an unlikely cause of the reduced DPOAE magnitudes. Other possibilities include effects on efferent pathways connecting to outer hair cells or a direct effect of HIV on the cochlea.
Structure of a NADH-Insensitive Hexameric Citrate Synthase that Resists Acid Inactivation (2006)

Acetobacter aceti converts ethanol to acetic acid, and strains highly resistant to both are used to make vinegar. A. aceti survives acetic acid exposure by tolerating cytoplasmic acidification, which implies an unusual adaptation of cytoplasmic components to acidic conditions. A. aceti citrate synthase (AaCS), a hexameric type II citrate synthase, is required for acetic acid resistance and, therefore, would be expected to function at low pH. Recombinant AaCS has intrinsic acid stability that may be a consequence of strong selective pressure to function at low pH, and unexpectedly high thermal stability for a protein that has evolved to function at approximately 30 degrees C. The crystal structure of AaCS, complexed with oxaloacetate (OAA) and the inhibitor carboxymethyldethia-coenzyme A (CMX), was determined to 1.85 A resolution using protein purified by a tandem affinity purification procedure. This is the first crystal structure of a "closed" type II CS, and its active site residues interact with OAA and CMX in the same manner observed in the corresponding type I chicken CS.OAA.CMX complex. While AaCS is not regulated by NADH, it retains many of the residues used by Escherichia coli CS (EcCS) for NADH binding. The surface of AaCS is abundantly decorated with basic side chains and has many fewer uncompensated acidic charges than EcCS; this constellation of charged residues is stable in varied pH environments and may be advantageous in the A. aceti cytoplasm.
SEMINAIRE INTERNATIONAL COMBUSTIBLES DE REMPLACEMENT, LIEGE, 25-27 MAI 1981. PROCEEDINGS (1981)

SOUS LE TITRE GENERAL SEMINAIRE INTERNATIONAL COMBUSTIBLES DE REMPLACEMENT, LES CONFERENCES SUIVANTES SONT REPRISES : L'EUROPE ET LA TRANSFORMATION DES COMBUSTIBLES SOLIDES (DE GREEF,A); LE COMMERCE INTERNATIONAL DU CHARBON (JANS,P); ESQUISSE D'UNE NOUVELLE METHODE DE PRODUCTION DE GAZ DE SYNTHESE PAR GAZEIFICATION SOUTERRAINE DU CHARBON (LEDENT,P); STATUS OF GASIFICATION WITH SPECIAL RESPECT TO THE DEVELOPMENT IN GERMANY (VAN HEEK,K-H); LA GAZEIFICATION DU CHARBON. ASPECTS ECONOMIQUES DES DIVERS PROCEDES (RIBESSE,J). ASPECTS OF DEVELOPMENT OF DIRECT LIQUEFACTION PROCESSES IN THE UNITED STATES (RUETHER,JA); SUPERCRITICAL EXTRACTION OF (WILLIAMS,DF); LIQUEFACTION OF IN THE FEDERAL REPUBLIC OF GERMANY (FRIEDRICH,F AND STROBEL,B); LA DEVOLATILISATION DU CHARBON (CYPRES,R); TRAITEMENT DES SABLES ASPHALTIQUES (MARECHAL,J); LES COMBUSTIBLES DERIVES DE DECHETS (HEINE,CH); COMBUSTIBLES DE REMPLACEMENT : POSSIBILITES AU DEPART DES BIOMASSES VEGETALES (GABELLIERI,R); LA FERMENTATION METHANIQUE DES DECHETS AGRICOLES (AUBART,CH); ECONOMIC ANALYSIS OF LIQUID REFINING (SIKONIA,JG, BENNETT,JR AND GEMBICKI,VA); TECHNICAL CONCEPTION OF SYNTHESIS GAS PLANTS BASED ON PARTIAL OXYDATION OF LIQUID AND SOLID HYDROCARBON FEEDSTOCKS (LEMBECK,H AND JUNGFER,H); INTEGRATION OF GAS-PURIFICATION AND SEPARATION PLANTS IN THE SASOL II OIL FROM COAL COMPLEX (SCHOLZ,W); LA METHANISATION DES GAZ DE TRANSFORMATION DU CHARBON (GERMAIN,A, PIRARD,JP ET CHEPPE,JP); METHANOL : RAW MATERIALS FOR GASEOUS FUELS (NEUKERMANN,H); CONVERSION OF METHANOL AND SYNTHESIS GAS TO HYDROCARBONS OVER ZSM-5 (BRENNAN,JA, GARWOOD,WE, YURCHAK, S. AND LEE,W); METHANOL AND SYNTHETIC FUELS FOR INTERNAL COMBUSTION ENGINES (ANDREW,S); LA SYNTHESE FISCHER-TROPSCH. HISTOIRE, SITUATION ACTUELLE, DEVELOPPEMENTS (HAMMER,H); LE TRANSPORT D'OXYGENE PAR CANALISATIONS (TRONCHON,C); ASPECTS TECHNICO-ECONOMIQUES DU TRANSPORT, DE LA DISTRIBUTION ET DE L'UTILISATION DES COMBUSTIBLES GAZEUX SYNTHETIQUES (RIBESSE,J); UTILISATION DES CARBUROLS DANS LES MOTEURS (GUIBET,JC ET GATEAU,P); GAZ DE BOUES POUR MOTEURS DUAL-FUEL (JAMOULLE,A); LE GAZ DE GAZOGENE : COMBUSTIBLE DE SUBSTITUTION POUR MOTEURS A COMBUSTION INTERNE (MARTIN,J); LE METHANOL : COMBUSTIBLE DE SUBSTITUTION POUR MOTEURS A COMBUSTION INTERNE (MARTIN,J ET PIRSON,J); VALORISATION OF VERY LOW CALORIFIC VALUE MATERIALS SUCH AS DUMP SHALES BY COMBUSTION IN FLUIDIZED BED AND STEAM PRODUCTION (DENOISEUX,R); TRAITEMENT DES DECHETS MENAGERS DE LA REGION LIEGEOISE (ROCMANS,C); PROBLEMES SANITAIRES DE LA TRANSFORMATION DES COMBUSTIBLES DE SYNTHESE (RONDIA,D ET GOL-WINCKEL,R). (VOIR EGALEMENT FICHES DIRR 117872 A 117876).
The Benefits of Resistance Training in Obese Adolescents: A Systematic Review and Meta-analysis (2022)

RT seems to be effective when the objective is to improve muscle strength, cardiorespiratory fitness and can be an efficient strategy to reduce obesity in adolescents by reducing body fat, waist circumference and body mass index. PROSPERO Registration number: CRD42022333411.
Estimation and visualization of neuronal functional connectivity in motor tasks (2009)

In brain-machine interface (BMI) modeling, the firing patterns of hundreds of neurons are used to reconstruct a variety of kinematic variables. The large number of neurons produces an explosion in the number of free parameters, which affects model generalization. This paper proposes a model-free measure of pairwise neural dependence to rank the importance of neurons in neural to motor mapping. Compared to a model-dependent approach such as sensitivity analysis, sixty percent of the neurons with the strongest dependence coincide with the top 10 most sensitive neurons trained through the model. Using this data-driven approach that operates on the input data alone, it is possible to perform neuron selection in a more efficient way that is not subject to assumptions about decoding models. To further understand the functional dependencies that influence neural to motor mapping, we use an open source available graph visualization toolkit called Prefuse to visualize the neural dependency graph and quantify the functional connectivity in motor cortex. This tool when adapted to the analysis of neuronal recordings has the potential to easily display the relationships in data of large dimension.
Brian Street and the LETTER Project (2022)

One of the many activities Brian was fond of quoting was the LETTER Project. He referred to it several times in his publications and it was this which caused him to write his book (with Alan Rogers) Adult Literacy and Development: stories from the field (2012). I am therefore glad of an opportunity to record something of this programme for him in this Special Memorial Issue.
In vivo Pharmacological Disease Models for Psoriasis and Atopic Dermatitis in Drug Discovery* (2006)

In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predictive in vivo models in order to introduce the right drug candidates into the clinical phases of development. Recent advances in dermatological in vivo pharmacological disease models for psoriasis and atopic dermatitis are reviewed together with a discussion of the rationale for their application in drug discovery.
Stability of Supported Amine Adsorbents to SO2 and NOx in Postcombustion CO2 Capture. 1. Single-Component Adsorption (2013)

Flue gases from coal-fired power plants typically contain not only CO2 but other acid-gas impurities such as SOx and NOx that can dramatically influence the CO2 capture efficiency. Whereas postcombustion CO2 capture by aminosilica materials has been extensively studied over the past few years because of their high equilibrium CO2 capacities, the performance of these materials under realistic conditions (in the presence of SOx, NOx, and O2) remains relatively unexplored. In this study, the degree of irreversible binding of SO2, NO, and NO2 to four supported amine adsorbents is evaluated to assess the SO2, NO, and NO2 adsorption capacities of aminosilica sorbents and their effects on the CO2 adsorption capacities. Adsorbents constructed using poly(ethyleneimine) and three different silane coupling agents (based on propyltrimethoxysilane linkers) with primary, secondary, and tertiary amines are evaluated. Under the experimental conditions used in this investigation, it is found that primary amines with high amine loadings displayed more affinity toward NO than their secondary and tertiary amine counterparts. However, overall, NO adsorption on the aminosilica adsorbents is low, and therefore, the CO2 capacities of the adsorbent materials exposed to NO remained almost unchanged after the exposure. In contrast, all materials showed a very high nitrogen dioxide adsorption capacity upon exposure to NO2. As a result, all adsorbents treated with NO2 exhibited a dramatic reduction in CO2 capacity, which corresponds to the deactivation of amine groups due to the irreversible binding of NO2. In addition, our results indicate that SO2 adsorbed significantly on supported amine adsorbents, resulting in a dramatic loss in CO2 capacity during CO2 capture from flue gas. With similar amine loadings, although secondary amines exhibited higher affinity to SO2, their CO2 capacity loss after exposure to SO2 is lower than that of primary amines, indicating that these materials are more stable in the presence of SO2, which implies that more SO2 desorbs from secondary amines during the desorption step. These results suggest that for silica-supported amine materials to be useful in practical CO2 capture applications, it is necessary to significantly reduce the SO2 and NO2 concentrations of the flue gas prior to the CO2 capture process. On the other hand, the capture efficiency of these materials does not change significantly in the presence of NO. This suggests that such materials might be promising for postcombustion CO2 capture from flue gas streams derived from natural gas combustion, as these streams typically contain reduced SO2 concentrations but can still have significant NOx concentrations.
Pharyngeal carriage of group B streptococci: detection by three methods (1977)

The prevalence of pharyngeal carriage of group B streptococci was evaluated in patients with and without the complaint of a sore throat by three methods (blood agar plates, Columbia CNA agar plates, and a selective enrichment broth containing gentamicin and nalidixic acid). The overall carriage rate of group B streptococci was 12%, and there was no significant difference between the two groups of patients. The selective broth medium was more sensitive than the two solid agar plate methods in detecting carriage, and 37% of all group B streptococci were recovered solely from the broth. Use of the broth alone would have permitted a 94% detection of the group B streptococcal carriers.