gebhart/patrepeval huggingface dataset:
Design for Optimal Parameter of Potential Method to a Mobile Robot in the Collision Avoidance Problems (2012)

In this paper, we consider taking tau-margin, which specifies time remaining before collision without information of speed and distance proposed in ecological psychology, into design of mobile robot. We try to reduce state-space and give the robot robustness for change in speed by using tau-margin. We carried out various simulations to evaluate the performance of hypnosis’s mobile robot. As a result, we confirmed the robot could achieve obstacle avoidance task regardless of changing in speed of robot. At the next stage, we are planning to test the usefulness of tau-margin to the implemented robot.Copyright © 2012 by ASME
Glia limitans superficialis oxidation and breakdown promote cortical cell death after repetitive head injury (2021)

Repetitive mild traumatic brain injuries (mTBI) disrupt CNS barriers, the erosion of which has been linked to long-term neurodegenerative and psychiatric conditions. Although much attention has been devoted to CNS vasculature following mTBI, little is known about the glia limitans superficialis - a barrier of surface-associated astrocytes that helps protect the CNS parenchyma and maintain homeostasis. Here, we identify the glia limitans superficialis as a crucial barrier surface whose breakdown after acute repeat mTBI facilitates increased cell death and recruitment of peripheral myelomonocytic cells. Using intravital microscopy, we show that brain-resident microglia fortify this structure after a single mTBI, yet they fail to do so following secondary injury, which triggers massive recruitment of myelomonocytic cells from the periphery that contribute to further destruction of the glia limitans superficialis but not cortical cell death. We demonstrate, instead, that reactive oxygen species (ROS) generated in response to repetitive head injury are largely responsible for enhanced cortical cell death, and therapeutic administration of the antioxidant glutathione markedly reduces this cell death, preserves the glia limitans, and prevents myelomonocytic cells from entering the brain parenchyma. Collectively, our findings underscore the importance of preserving the glia limitans superficialis after brain injury and offer a therapeutic means to protect this structure and the underlying cortex.
The aqueous humor drainage mechanism in the cynomolgus monkey (Macaca irus) with evidence for unconventional routes. (1965)

centration after 1 minute, while throughout the experiments the diodone concentration in the effluent remained lower than expected from, a bulk flow through well-defined channels. The low concentration was due to a rapid diffusion of diodone into the tissues of the limbus region. The labeled albumin entered the uvea and the sclera in such amounts as to indicate that about 20 per cent of the labeled fluid had passed out by way of unconventional uveoscleral routes. The results suggest that more than 90 per cent of the conventional drainage was carried by pores xoith an apparent diameter of more than 0.16 n. t has been demonstrated in many ways that in the primate eye aqueous humor flows from the anterior chamber into Schlemm's canal. It is quite clear that the aqueous first passes into the spaces of the trabecular meshwork but how it then passes through the inner wall of Schlemm's canal is a matter of question. Much physiologic evidence 1 4 suggests that the flow occurs
More than meets the eye (2003)

The last of our articles exploring how picture books can be used within the prime and specific areas of learning. This month, we take a look at Literacy, Physical development and Expressive arts and design.
Application and Practice of Microservice Architecture in Multidimensional Electronic Channel Construction (2019)

State Grid information construction has gained a great achievements in the wave of mobile Internet development and impact of the "Internet plus" action plan. At the same time, there are some problems in the informationizing of multi-dimensional marketing e-service channels, such as the overlapping of channels, the insufficient integration of channels and lack of data sharing in various channels. The complex business operation of the channels in the traditional single-architecture mode. After the development of the microservices architecture in the current industry research shows that microservices-based architecture model system can be very well to solve the problems encountered in the construction of information technology. The final multidimensional electronic channel system construction using Docker container technology as a microservices architecture technology solutions, which greatly improved the system capacity and operation and maintenance the efficiency of system, and also provided a strong technical support for the construction of national network information.
Characteristics and Outcome of Patients with Acute Myeloid Leukemia (AML) Refractory to One Cycle of High Dose Cytarabine-Based Induction Chemotherapy. (2009)

Abstract Abstract 1038 Poster Board I-60 Background: Outcome of patients (pts) with AML refractory to initial induction is assumed to be poor but the available data is limited. Furthermore, pts refractory to standard dose cytarabine-based regimens may be salvaged with high dose ara-C (HiDaC, defined as daily ara-C dose ≥ 1 g/m2). Information on the outcome of pts refractory to initial HiDaC - based induction is more limited. Aim To better characterize predictors of poor response to HiDaC-based induction and to evaluate the outcome of pts refractory to such induction regimens. Methods: We identified pts treated with induction regimens containing HiDaC at the University of Texas – M D Anderson Cancer Center who did not achieve a compete remission (CR) after one cycle of induction. We examined their pre-treatment characteristics and compared them with similar pts achieving a CR. We also examined their response to salvage chemotherapy and outcome. Results: Among 1179 pts treated with HiDaC-based induction therapy from 1995 to 2009, 285 were primary refractory to one course of induction. Their median age was 59 (range, 18 - 85). Median pretreatment WBC was 9.0 × 109/L (range, 0.3 – 394 × 109/L). Cytogenetics included-5/-7/complex 101 (35%), diploid 85 (30%), other intermediate 98 (34%), favorable 1 (&lt;1%). 165 (58%) pts had antecedent hematological disorder. Induction regimens used included HiDaC with anthracyclines (n=181, 64%), HiDaC with non-anthracycline chemotherapy (fludarabine, clofarabine, topotecan, and troxacitabine) (n=104, 36%) Pts with primary refractory disease were older (Median age 59 vs. 56; p=000004), more likely to have chromosome 5/7 or complex cytogenetic abnormalities (P=0.0001), more likely to have AHD (p=0.0001), and had a higher presentation WBC (P=0.036), but not a higher incidence of FLT3 mutations (p=0.85) than those achieving CR. Primary refractory disease was not more likely with non-anthracycline containing regimens than those with anthracyclines (p=0.58). Salvage chemotherapy included combination chemotherapy in 111 (39%)(non-ara-C regimen in 40, containing ara-C in 71), single agent chemotherapy in 64 (22%), allogeneic stem cell transplant in 22 (8%) and none in 88 (31%). Forty-three (15%) pts responded to salvage including 35 CR and 8 CRp. 114 (58%) pts were resistant and 35 (18%) died; 5 (3%) were lost to follow-up. With a median follow-up of 115 weeks (range 8 – 347 weeks) in pts responding to salvage, 21 pts (7%) were alive and in CR, for at least 6 months including 14 who underwent an allogeneic stem cell transplant (median overall survival for these 21 pts, 30 months; range, 13 to 87 months). Conclusions: Outcome of pts with disease refractory to HiDaC-based induction is poor. Alternative strategies are needed in these pts who are likely to be resistant to standard chemotherapy. Disclosures: No relevant conflicts of interest to declare.
Using bilingual knowledge and ensemble techniques for unsupervised Chinese sentiment analysis (2008)

It is a challenging task to identify sentiment polarity of Chinese reviews because the resources for Chinese sentiment analysis are limited. Instead of leveraging only monolingual Chinese knowledge, this study proposes a novel approach to leverage reliable English resources to improve Chinese sentiment analysis. Rather than simply projecting English resources onto Chinese resources, our approach first translates Chinese reviews into English reviews by machine translation services, and then identifies the sentiment polarity of English reviews by directly leveraging English resources. Furthermore, our approach performs sentiment analysis for both Chinese reviews and English reviews, and then uses ensemble methods to combine the individual analysis results. Experimental results on a dataset of 886 Chinese product reviews demonstrate the effectiveness of the proposed approach. The individual analysis of the translated English reviews outperforms the individual analysis of the original Chinese reviews, and the combination of the individual analysis results further improves the performance.
IP routing table compression using ESPRESSO-MV (2004)

In an attempt to slow the exhaustion of Internet protocol (IP) address space, class-less inter-domain routing (CIDR.) was adopted. However, the decision to utilize CIDR also increases the size of the routing table, since it allows an arbitrary partitioning of the routing space. In this paper, we propose a scheme to reduce the size of routing table in the CIDR context. Our approach utilizes a well-known and highly efficient technique to perform multi-valued logic minimization. This technique, implemented using ESPRESSO-MV, is extensively used in multi-valued VLSI logic function optimization. Our approach for IP routing table compression leverages the full flexibility and power of ESPRESSO-MV. By considering the IP routing table as an incompletely specified multi-valued function, we demonstrate that our technique can achieve average 77% reduction in the size of IP routing tables. Our algorithm requires exactly one espresso run, as opposed to O(MN) runs for an existing algorithm, where M is the number of unique masks and N is the number of interfaces in the routing table.
Adding a novel material to the 2D toolbox (2016)

Die Sammlung der zwei-dimensionalen (2D) Materialien ist begrenzt, da sehr wenige Verbindungen stabil bleiben, sobald sie nur aus Oberflächen bestehen. Aufgrund ihrer außergewöhnlichen Eigenschaften sind 2D Materialien jedoch nach wie vor überaus begehrt. Vor kurzem wurden atomar definierte, chemisch gesättigte SiO2 Bilagen auf verschiedenen Metalloberflächen präpariert. Eine solche ultradünne Silika-Lage wäre eine vielversprechende Ergänzung zur Familie der 2D Materialien, wenn sie unter Strukturerhalt vom Wachstumssubstrat isoliert werden kann. In dieser Arbeit untersuchen wir die Eigenschaften einer Silika-Bilage im Zusammenhang mit Anwendungen von 2D Materialien. Die Bilage besitzt kristalline und amorphe Regionen, die beide atomar glatt sind. Die kristalline Region besitzt ein hexagonales Gitter mit gleichmäßiger Porengröße, während die amorphe Region einer komplexeren Beschreibung bedarf. In einer Studie von Baublöcken zeigen wir, dass mittelreichweitige Struktureinheiten in Korrelation mit einem Parameter für die Bindungswinkelfrustration auftreten. Das Netzwerk verschiedener Nanoporen stellt eine größenselektive Membran dar, wie wir in einer Adsorptionsstudie zeigen. Pd- und Au-Atome durchdringen den Silikafilm abhängig von der Größe der zur Verfügung stehenden Nanoporen. Der ultradünne Film hält der Einwirkung verschiedener Lösungsmittel stand und die Beständigkeit der Struktur in Wasser wird analysiert. Diese Studien deuten die außergewöhnliche Stabilität dieser Struktur an. Wir entwickeln eine polymerbasierte mechanische Exfoliation, um den Film von seinem Wachstumssubstrat zu entfernen, und zeigen, dass der Film als intakte Einheit vom Substrat abgelöst wird. Wir präsentieren anschließend den Transfer des Silikafilms auf ein TEM-Gitter, wo er schraubenartig gewundene Formen annimmt. Weiterhin wurde der Film auf ein Pt(111)-Substrat transferiert. In diesem Fall wird unter Erhalt der Struktur ein Transfer in der Größenordnung von Millimetern erreicht.
Optical Coherence Tomography Scan Circle Location and Mean Retinal Nerve Fiber Layer Measurement Variability (2008)

The location of the OCT scan circle affects RNFL thickness measurements. Accurate registration of OCT scans is essential for measurement reproducibility and longitudinal examination (ClinicalTrials.gov number, NCT00286637).
The Mitochondrial Epigenome: a Role in Alzheimer’s Disease? (2014)

Considerable evidence suggests that mitochondrial dysfunction occurs early in Alzheimer's disease, both in affected brain regions and in leukocytes, potentially precipitating neurodegeneration through increased oxidative stress. Epigenetic processes are emerging as a dynamic mechanism through which environmental signals may contribute to cellular changes, leading to neuropathology and disease. Until recently, little attention was given to the mitochondrial epigenome itself, as preliminary studies indicated an absence of DNA modifications. However, recent research has demonstrated that epigenetic changes to the mitochondrial genome do occur, potentially playing an important role in several disorders characterized by mitochondrial dysfunction. This review explores the potential role of mitochondrial epigenetic dysfunction in Alzheimer's disease etiology and discusses some technical issues pertinent to the study of these processes.
An Intrusion Detection Model Based on Non-Negative Matrix Factorization (2011)

In this paper ,we discus a wide class of loss functions for non-negative matrix factorization (NMF) and derive flexible and improved NMF algorithms based alpha-divergences for error measures, which generalize or combine several different criteria in order to extract intrusion signal.
[Experimental bases for photodynamic laser therapy in chronic polyarthritis]. (1996)

The principle of photodynamic laser therapy (PDT) for chronic polyarthritis consists in specifically concentrating a drug (photosensitizer) in the synovium. Subsequent activation of the photosensitizer by means of laser leads to a cytotoxic effect. The practicability of PDT was first shown in cell cultures of human synovial fibroblasts. For further tests an animal model consisting of IgG-induced arthritis in rabbits was used. In this model, concentration of the photosensitizer in the synovial lining cells, in the media of arteries and in the lymphoid infiltrate was seen. After laser irradiation there was total selective demarcation of the synovium. In contrast, bradytrophic tissues such as cartilage, meniscus and ligament structures were changed neither macroscopically nor microscopically. In the animal model PDT combines high selectivity with minimal invasiveness and can be used in small joints. PDT thus offers ideal preconditions for future minimal invasive treatment of chronic inflammatory joint diseases.
Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks (2018)

In this study, we proposed a high-throughput separation strategy of the binary colloid mixture by dielectrophoresis (DEP) induced around large-scale bipolar electrode arrays embedded in microfabricated fluidic networks via a thorough numerical investigation. The usage of a floating electrode (FE) eliminates the need of external Ohmic connection to individual array units, therefore potentially steering the faddish design of new microdevice structures. Diffuse charge dynamics within the induced double layer at opposite ends of every FE permit a sinusoidal electric field to penetrate throughout the whole device, as long as the imposed field frequency is beyond the reciprocal resistor-capacitor time constant at the electrode/electrolyte interface. In this special device configuration, FEs interconnect multiple microchannels arranged in parallel. Pockets embedded on the sidewalls of fluidic channels help create strong field gradients at the tip of FEs and sharp pocket/channel junctions, improving the trapping performance of incoming bioparticles subjected to positive-DEP (pDEP) force, while latex beads experiencing negative-DEP (nDEP) stress are electrically squeezed to the midchannel and finally exit as a series of co-flowing thin streams with unequal translatory velocity. Taking the synergy of DEP force, induced-charge electro-osmosis, alternating-current electrothermal streaming, pressure-driven flow, and buoyancy effect into consideration, a numerical model is established to account for motion trajectories of micro-entities in full-scale three-dimensional space using the Lagrange particle track algorithm, as well as testing the feasibility of the device design in separation of the binary mixture containing yeast cells and polystyrene beads. Applying suitable voltage parameters of frequency O(1) MHz and electric field strength O(10) V/mm, highly efficient DEP separation is theoretically achievable under inlet flow velocity on the order of O(1) mm/s, where most of incoming yeasts are captured by pDEP within these five parallel branching channels, while polystyrene spheres are repelled by nDEP away from the FE array to form slim beams co-flowing into the outlet according to the calculation results. The microfluidic separation device exploiting the FE array offers great potential to build up scalable electrokinetic platforms for high-throughput on-chip sample treatment.
Automated Reflectance Measurement System Designed and Fabricated to Determine the Limits of Atomic Oxygen Treatment of Art Through Contrast Optimization (2000)

Atomic oxygen generated in ground-based research facilities has been used to not only test erosion of candidate spacecraft materials but as a noncontact technique for removing organic deposits from the surfaces of artwork. NASA has patented the use of atomic oxygen to remove carbon-based soot contamination from fire-damaged artwork. The process of cleaning soot-damaged paintings with atomic oxygen requires exposures for variable lengths of time, dependent on the condition of a painting. Care must be exercised while cleaning to prevent the removal of pigment. The cleaning process must be stopped as soon as visual inspection or surface reflectance measurements indicate that cleaning is complete. Both techniques rely on optical comparisons of known bright locations against known dark locations on the artwork being cleaned. Difficulties arise with these techniques when either a known bright or dark location cannot be determined readily. Furthermore, dark locations will lighten with excessive exposure to atomic oxygen. Therefore, an automated test instrument to quantitatively characterize cleaning progression was designed and developed at the NASA Glenn Research Center at Lewis Field to determine when atomic oxygen cleaning is complete.
Calcium alginate cross-linked polymeric microbeads for oral sustained drug delivery in arthritis. (2010)

After the successful optimization and development of a drug entity, design of dosage form then plays an important role. Hence, research continuously keeps on searching for ways to deliver drugs over an extended period of time. With aceclofenac, a novel NSAID used in the treatment of rheumatoid arthritis, frequency of administration may cause certain GI-adverse effects. The objective of the present research work was to develop a microparticulate oral sustained release dosage form, to reduce dosing frequency, to eliminate the dose related adverse effects and to ultimately improve compliance in the pharmacotherapy of arthritis. The microbeads were prepared by an ionotropic external gelation technique, by using sodium alginate as the hydrophilic carrier and calcium chloride as the cross-linking agent. The shape and surface characteristics were determined by scanning electron microscopy (SEM). Particle size distribution was determined by an optical microscope. The physical state of the drug in the formulation was determined by differential scanning calorimetry (DSC). While increasing the concentration of sodium alginate dispersion increased flow properties, mean particle size, swelling ratio and drug entrapment efficiency. The mean particle sizes of drug-loaded microbeads were found to be in the range 596.45 ± 1.04 to 880.10 ± 0.13 μm. The drug entrapment efficiency was obtained in the range of 63.24-98.90% (w/v). The release of drug from the microbeads at pH 1.2 is negligible. Under neutral conditions, the beads will swell and the drug release depends on swelling and the erosion process resulting in an optimum level of drug released in a sustained manner which exhibits zero-order kinetics.
Solar variability indications from Nimbus 7 satellite data (1981)

Patients evaluated by paramedics but not transported to the hospital account for 50% to 90% of emergency medical services lawsuits. We reviewed 2,698 consecutive paramedic run reports to examine documentation in these cases. Documentation criteria for prehospital patient release were history, physical examination, vital signs, mental status, lack of significant mental impairment, and for patients refusing care, that risks of refusing were understood. Criteria for appropriate release were met in 65.2% of cases. Criteria omitted in inappropriate releases were risks of refusing care in 481 (51.3% of inappropriate releases), vitals in 320 (34.1%), mental status in 188 (20.0%), lack of impairment in 120 (12.8%), and history or physical in 19 (2.0%) cases. Age from 0 to 14 and 65 or more years and prehospital assessment of hyperventilation, psychiatric emergency, choking, infection, and patient deceased were significantly associated with appropriate release. Age from 35 to 54 years and prehospital diagnosis of no injury, head injury, seizure, minor trauma, and ethanol use were significantly associated with inappropriate releases. There was no association of appropriate release or inappropriate release with patient sex, contact with medical control, length of encounter, or time of day. Only one patient complication was believed due to inappropriate triage; this could be improved by implementation of standardized criteria.
p53 IS AN INDEPENDENT PREDICTOR OF TUMOR RECURRENCE AND PROGRESSION AFTER NEPHRECTOMY IN PATIENTS WITH LOCALIZED RENAL CELL CARCINOMA (2005)

p53 is a significant molecular predictor of tumor recurrence, as identified in patients undergoing treatment for localized RCC.
Channel estimation for mobile OFDM systems (1999)

In this paper we investigate pilot-based channel estimation schemes for mobile OFDM systems. Time variance of the mobile channel leads to a loss of subcarrier orthogonality, resulting in intercarrier interference (ICI). Channel estimation schemes based on pilot tones, which are also subject to ICI, will therefore suffer a performance degradation. In this article we analyse linear minimum mean squared error (LMMSE) estimators to reduce the noise due to ICI and propose two channel estimation schemes which perform interpolation of the noise-reduced pilot tones in the time-direction prior to frequency interpolation. Performance evaluations are based on the European digital television system DVB-T. Receiver complexity is examined for the advanced time-interpolation schemes and compared to state of the art receivers for stationary reception.