gebhart/patrepeval huggingface dataset:
ATF7 mediates TNF-α–induced telomere shortening (2018)

Telomeres maintain the integrity of chromosome ends and telomere length is an important marker of aging. The epidemiological studies suggested that many types of stress including psychosocial stress decrease telomere length. However, it remains unknown how various stresses induce telomere shortening. Here, we report that the stress-responsive transcription factor ATF7 mediates TNF-α-induced telomere shortening. ATF7 and telomerase, an enzyme that elongates telomeres, are localized on telomeres via interactions with the Ku complex. In response to TNF-α, which is induced by various stresses including psychological stress, ATF7 was phosphorylated by p38, leading to the release of ATF7 and telomerase from telomeres. Thus, a decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice. These findings give credence to the idea that various types of stress might shorten telomere.
Experiments with the role of parents in primary education in the Netherlands (1999)

Background The research concerns the participation of parents (or other care-takers of children) in activities at primary schools in the Netherlands. In most cases, parent participation refers to the situation in which parents actively participate, or w ill participate, in their children's education. Some thirty years ago, parent participation was started on the basis of the idea that goo d contacts between the school and the parents would be in the interest of the child. It would benefit the pupils if also parents would be welcome at school. Besides ‘participating’, parents also wanted to have a say in w hat their children learn and how education is given shape (Smit & Van Esch, 1993).
Synthesis of dihydrofuro[2,3‐b]pyridines by the reaction of 2‐amino‐4,5‐dihydro‐3‐furancarbonitriles with α,β‐unsaturated carbonyl compounds (2002)

Abstract The reactions of 2‐amino‐4,5‐dihydro‐3‐furancarbonitriles 1a‐d with α,β‐unsaturated carbonyl compounds in the presence of sodium ethoxide (0.1 equivalent) gave the corresponding Michael adducts 2a‐d , 3a‐d and 4a‐d. Compounds 2a‐d and 3a‐c reacted with sodium alkoxide (1 equivalent) to yield the corresponding 7a‐alkoxyhexahydrofuro[2,3‐ b ]pyridines 5a‐d, 6a‐d, 7a‐c and 8a‐c . Treatment of 5a‐d, 6a‐d, 7a‐c and 8a‐c with potassium tert ‐butoxide produced the corresponding dihydrofuro[2,3‐ b ]pyridines 9a‐d and 10a‐c . The reaction of 4a‐c with sodium ethoxide (1 equivalent) afforded the corresponding dihydro‐furo[2,3‐ b ]pyridines 11a‐c .
RIGID RISERS FOR TANKER FPSOS (1995)

Recent development work on the subject of dynamic rigid (steel pipe) risers demonstrates that their scope of application extends beyond that of TLPs in mild environments. Steel catenary configurations can be used on tanker FPSO vessels even in harsh environments typical of the Atlantic Frontier. The potential cost savings over use of flexible risers is large. The technology is suited to a wide range of diameters and with correct material selection, can be used for aggressive and high pressure service conditions.
Identification of topography of surfaces created by turning biomaterials with optical profilometry (2020)

This study deals with the identification of the topography of the surface that is created by machining composite materials with natural fibres (biomaterials, wood-plastic composites – a material with plastic matrix and natural reinforcement). The final surface was evaluated based on tool geometry (turning technology), and the influence of the tool on selected evaluating parameters of the obtained surface was evaluated using a non-contact method, applying an optical profilometer (MicroProf FRT). After machining the surface, characteristic relief (a trace on the surface of the material) was visible depending on the machining factors combination (machine, tool, workpiece, and fixture). The initial material also played a prominent role in the surface monitoring, in relationship to the composition of the material and the interaction between the matrix and reinforcement, i.e., detection of defects in the area of the interaction between the initial components.
Supplementary Figure S3 from Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers (2023)

&lt;p&gt;Supplementary Figure S3 - PDF file 1337K, LNCaP cell cycle distribution by PI and BrdU analyses plus or minus ARN-509&lt;/p&gt;
Tuning\nOxygen Vacancy Diffusion through Strain in\nSrTiO<sub>3</sub> Thin Films (2018)

Understanding diffusion\nof oxygen vacancies in oxides under different\nexternal stimuli is crucial for the design of ion-based electronic\ndevices, improvement of catalytic performance, and so forth. In this\nmanuscript, using an external electric field produced by an atomic\nforce microscopy tip, we obtain the room-temperature diffusion coefficient\nof oxygen-vacancies in thin films of SrTiO&lt;sub&gt;3&lt;/sub&gt; under compressive/tensile\nepitaxial strain. Tensile strain produces a substantial increase of\nthe diffusion coefficient, facilitating the mobility of vacancies\nthrough the film. Additionally, the effect of tip bias, pulse time,\nand temperature on the local concentration of vacancies is investigated.\nThese are important parameters of control in the production and stabilization\nof nonvolatile states in ion-based devices. Our findings show the\nkey role played by strain for the control of oxygen vacancy migration\nin thin-film oxides.
A novel converter for noncontact charging with electromagnetic coupling (2005)

A DC-to-DC converter suitable for noncontact charging for the rechargeable cell using the electromagnetic coupling is presented. The circuit is of self-oscillated class C DC-to-DC converter. In this method, a class C converter is used for reducing the switching loss and the core loss of the transformer. The oscillating condition as a class C converter is automatically adjusted by a simple bias circuit which is made of a diode and a resistor. The zero voltage switching is realized by a resonance of the parasitic parameters of the transformer. Through electromagnetic coupling using this class C converter, we have obtained a noncontact type battery charger of 90% efficiency, under the input and output voltages and output power are 140 V, 12 V and 5 W respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
HEAT SHOCK PROTEINS (1995)

Research Institute, Hospital de la Candelaria, Tenerife, Spain; and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rash (2012)

Varicella-zoster virus (VZV) causes varicella (chickenpox), becomes latent in ganglia along the entire neuraxis, and may reactivate to cause herpes zoster (shingles). VZV may infect ganglia via retrograde axonal transport from infected skin or through hematogenous spread. Simian varicella virus (SVV) infection of rhesus macaques provides a useful model system to study the pathogenesis of human VZV infection. To dissect the virus and host immune factors during acute SVV infection, we analyzed four SVV-seronegative Chinese rhesus macaques infected intratracheally with cell-associated 5 × 10³ plaque-forming units (pfu) of SVV-expressing green fluorescent protein (n = 2) or 5 × 10⁴ pfu of wild-type SVV (n = 2). All monkeys developed viremia and SVV-specific adaptive B- and T-cell immune responses, but none developed skin rash. At necropsy 21 days postinfection, SVV DNA was found in ganglia along the entire neuraxis and in viscera, and SVV RNA was found in ganglia, but not in viscera. The amount of SVV inoculum was associated with the extent of viremia and the immune response to virus. Our findings demonstrate that acute SVV infection of Chinese rhesus macaques leads to ganglionic infection by the hematogenous route and the induction of a virus-specific adaptive memory response in the absence of skin rash.
Causality properties of the energy-momentum tensor of the living cells by the low temperatures. (2009)

TSVETKOV, Tsv. D., G. PETROV and P. TSVETKOVA, 2009. Causality properties of the energy-momentum tensor of the living cells by the low temperatures. Bulg. J. Agric. Sci., 15: 487-493 From the theory and experiment to day it’s known the vacuum is a ground state of the quantum field. It is not just “nothing” but has a rich structure, which determines its possible seeing or virtual excitations, the particle spectrum. At the molecular level with thermodynamic behaviour is considered by any electromagnetic quantum field that the additional boundaries as by the Casimir effect changes the energy of the vacuum and then it depends from the distance between the boundaries, the two parallel, perfectly conducting square plates (side L, distance d, L>d), moved inertial to each other, so that the so-called Casimir force can be calculated theoretically. The Casimir force for electromagnetic field has been measured with great accuracy, proving at its best the reality and non-triviality of the quantum vacuum. By the calculation of the Casimir effect it has been obtained by the help of the quantum field methods the vacuum by weak gravitation and electric force as a ground state of the quantum fields fulfilled the void space between the boundaries e.g. the empty space between the molecules in the living cells. From the recent consideration of the temporal organization of the leaving cells to discussing the quantization on the foliation in a causality form of generalized quantum field theory we show how the discussion in (Tsvetkov et al., 2005) of a time arrow version of free generalized scalar field theory can be augmented in such way as to include the energy momentum tensor of the quantizing non local generalized quantum field depended of the time-like vector kxμ that determines a Lorentzian foliation of Minkowski space-time in the non local sense. So the classical thermodynamically model of the living cells can be obtained as a relativistic thermodynamically model by the help of the energy momentum tensor of the relativistic biophysical system called living cell. By the heat transmissions it is possible to obtain a heat 4-impulse k μ where the 0-component k 0 is obtained by heat difference δQ = Φdt and k i = Π i dt (i= 1,2,3) where Φ and Π i are the energy and the impulse transmits of the convection way to the local event points for unit time in the Minkowski space-time.
Assessment of the Impeller/Volute Relationship of Centrifugal Fans From an Aerodynamic and Aeroacoustic Perspective (2022)

Abstract Heavy-duty centrifugal fans require high reliability and first-class performance. Besides, extreme conditions and harsh environments are often encountered, such as in the papermaking process, in steel or cement plants or the chemical and petrochemical industry. Therefore, the design of high performance heavy-duty industrial fans requires robust yet efficient solutions. Previous work indicates a high aerodynamic and aeroacoustic sensitivity concerning the specific position of the volute cut-off (tongue). This effect will be further investigated, not by directly changing the orientation of the cutoff, but by varying the position of the impeller relative to a fixed volute casing. The initial evaluation is done through a numerical study of three influencing parameters, which allows the aerodynamic dependencies to be modelled using low-layer artificial networks. Subsequently, extensive experimental studies were carried out to validate the aerodynamic dependencies and also to incorporate information on the aeroacoustic performance. The obtained results show that the operating point represents the key factor in determining the optimal positioning, with qualitatively comparable dependencies found for both tested fans. From an aeroacoustic point of view, the determined optimal configuration does not necessarily coincide with the observed aerodynamic desires, so careful analysis and a reasonable compromise are required, motivating for a multi-objective optimisation process.
Development and optimization by experimental design of solid phase microextraction gas chromatography triple quadrupole mass spectrometry methods in aqueous matrices (2012)

Dottorato di Ricerca in Organic Materials of Pharmacological Interest, Ciclo XXV, a.a. 2011-2012
Deposition of silicon oxide films from TEOS by low frequency plasma chemical vapor deposition (1993)

Recently, TEOS has been studied as a silicon source of silicon oxide films deposited by plasma chemical vapor deposition (CVD) because the deposited films show good step coverage compared with films deposited from SiH4. In this work, the authors deposited silicon oxide films using TEOS as a silicon source by using a low frequency (50 Hz) plasma CVD. It has been demonstrated in previous articles that low frequency (50 Hz) plasma CVD can deposit high quality silicon nitride films and amorphous carbon films without substrate heating. It is found in the present work that the substrate heating at deposition is required to obtain acceptable electrical properties when silicon oxide films are deposited from a TEOS and oxygen mixture, even by low frequency (50 Hz) plasma CVD. The films deposited at 200 °C from the plasma of a 3% TEOS mixture were found to be high quality insulating films; the resistivity was 1016 Ω cm and the breakdown strength 7×106 V/cm. Moreover, Auger electron spectrum analysis revealed that carbon atoms were not detected from the films in spite of the presence of carbon atoms in the TEOS molecule. With optical emission spectrum analysis of the TEOS and oxygen mixture plasma, strong emissions from the CO and CO2 molecules were observed. It may be concluded that in the plasma carbon atoms react with oxygen atoms to yield the CO and CO2 molecules which are stable enough to remain in the gas and thus not be taken into the films.
Effect of Holding Time on Populations of Microparticles in Spheroidal Graphite Irons (2022)

Abstract Non-metallic microparticles in spheroidal graphite irons are a product of the inoculation and the Mg-treatment of the liquid melt. Besides the influence on the mechanical properties of these iron–carbon–silicon alloys, they are also responsible for the nucleation and the morphology of the graphite phase. The present investigation is undertaken to study holding time effects of a (Ba, Ca, Al)–ferrosilicon (called Ba-inoculant) and (Ca, Al)–ferrosilicon (called Ca-inoculant) inoculants on the overall distribution of microparticles. Using the 2D to 3D conversions method, which is typically used for graphite nodules, the non-metallic microparticles’ statistical parameters, such as size distributions and number densities, are quantified. The total number of particles is similar after Mg-treatment and inoculation for Ca-inoculant but not for Ba-inoculated samples, which lose approximately 25 pct of microparticles after 1 minute of holding time. Iron treated with the Ca-inoculant loses about 37 pct of its nodules after 5 minutes, while the Ba-inoculated melts maintain their performance even after 10 minutes. Based on extrapolating the trend of the undercooling, Ba-inoculated samples would reach the uninoculated undercooling values in 48 minutes, while Ca-inoculated samples in only 11 minutes. By evaluating the size distributions of the non-metallic microparticles, the Ostwald ripening hypothesis or particle aggregation can be verified. The results suggest that sulfides are more critical for graphite nucleation since they can be correlated with the graphite number densities. However, due to the small difference in the microparticle population of the uninoculated sample with Ca-inoculated samples, other aspects of the fading mechanism need to be considered, such as transient metastable states, since the central hypothesis of loss of inclusions cannot alone explain the decrease in the nucleation frequency of graphite.
[Detection of Campylobacter species by using polymerase chain reaction and nonradioactive DNA probes. II. PCR direct sequencing of the Campylobacter DNA]. (1992)

We have developed a sensitive DNA hybridization assay for the detection and identification of Campylobacter species which are recognized as important pathogens of acute diarrheal disease in humans. This technique utilizes DNA probes complementary to nucleotide sequences present in 16S ribosomal RNA (rRNA) of C. jejuni, C. coli, C. laridis, C. fetus, C. fetus subsp. fetus, C. fetus subsp. venerealis and C. hyointestinalis, and polymerase chain reaction. The partial sequence of DNAs encoding the Campylobacter rRNA was first analyzed by direct solid phase sequencing in order to select suitable DNA probes. Amplified target DNA of 240 base pairs could be resolved on ethidium bromide-stained gels, and hybridized with DNA probes conjugated to alkaline phosphatase. In identification experiments, one of the 10 probes tested here gave a positive hybridization reaction with C. jejuni, C. coli and C. hyointestinalis but not with other Campylobacter species. The other was specifically reactive with C. fetus, C. fetus subsp. fetus and C. fetus subsp. venerealis. When applied to stool specimens, a good correlation was found between the results obtained by the present assay and by biochemical tests. These findings suggest that the nonradioactive probe assay can be used as the practical criterion for differentiating Campylobacter species.
Barium Holmium Zirconate, A New Perovskite Oxide: II, Synthesis as Nanoparticles through a Modified Combustion Process (2002)

Nanoparticles of barium holmium zirconate, a new complex perovskite ceramic oxide, has been synthesized using a modified self‐propagating combustion process. The solid combustion products obtained were characterized by X‐ray diffraction (XRD), electron diffraction, differential thermal analysis, thermogravimetric analysis, infrared spectroscopy, particle size analysis, surface area determination, and high‐resolution transmission electron microscopy. The XRD and electron diffraction studies have shown that the as‐prepared powder is phase pure Ba 2 HoZrO 5.5 and has a complex cubic perovskite (A 2 BB′O 6 ) structure with a lattice constant a = 8.428 Å. The transmission electron microscopic investigation has shown that the particle size of the as‐prepared powder was in the range 4–16 nm with a mean grain size of 8.2 nm. The nanoparticles of Ba 2 HoZrO 5.5 obtained by the present method could be sintered to 98% theoretical density at 1500°C.
Nanoparticles as a vaccine adjuvant of anti-idiotypic antibody against schistosomiasis. (2004)

Nanoparticle CA could act as a vaccine adjuvant of anti-idiotypic antibody NP30 against schistosomiasis. The mechanism could be that CA-NP30 enhances humoral and cellular immune responses in mice.
Contributions of Direct and Indirect Alloresponses to Chronic Rejection of Kidney Allografts in Nonhuman Primates (2011)

The relative contribution of direct and indirect allorecognition pathways to chronic rejection of allogeneic organ transplants in primates remains unclear. In this study, we evaluated T and B cell alloresponses in cynomolgus monkeys that had received combined kidney/bone marrow allografts and myeloablative immunosuppressive treatments. We measured donor-specific direct and indirect T cell responses and alloantibody production in monkeys (n = 5) that did not reject their transplant acutely but developed chronic humoral rejection (CHR) and in tolerant recipients (n = 4) that never displayed signs of CHR. All CHR recipients exhibited high levels of anti-donor Abs and mounted potent direct T cell alloresponses in vitro. Such direct alloreactivity could be detected for more than 1 y after transplantation. In contrast, only two of five monkeys with CHR had a detectable indirect alloresponse. No indirect alloresponse by T cells and no alloantibody responses were found in any of the tolerant monkeys. Only one of four tolerant monkeys displayed a direct T cell alloresponse. These observations indicate that direct T cell alloresponses can be sustained for prolonged periods posttransplantation and result in alloantibody production and chronic rejection of kidney transplants, even in the absence of detectable indirect alloreactivity.
η-Cyclopentadienyl molybdenum imido compounds; halo, alkene, alkyne, allyl and tertiary phosphine derivatives (1992)

The new imido compounds [M(η-C5H4R)Cl2(NR′)]*(M = Mo, R = H, R′= But, Prn or Ph; M = Mo, R = Me, R′= But or Ph; M = W, R = H, R′= But), [Mo (η-C5H4R)Cl(L)(NR′)](R = H, R′= But, L =η-C2H4, or η-C2Me2; R = Me, R′= But, L = C2H4*; R = H, R′= Ph, L =η-C2Me2), [{Mo(η-C5H4R)(η-C2H4)(NBut)}2Hg]*(R = H, Me), [Mo (NBut)Cl2(PMe3)3], [Mo(η-C5H5)Cl3(NBut)] and the π-allyl complex [Mo(η-C5H4Me)(η-C3H5)(NBut)] are synthesised; *indicates that the crystal structure has been determined.
Comparison of Turn-Off Strategies for SiC Thyristors (2015)

Three different turn-off strategies are presented for 6.5 kV class SiC Thyristors. A cathode current of 62 A (284 A/cm 2 ) is successfully turned off by applying a reverse bias of ≈ 30 V to the cathode of a SiC Thyristor. The minimum turn-off time (t q ) for the Thyristor using this forced commutation technique is investigated as a function of cathode current density, reverse gate current and the dV/dt of the re-applied forward (blocking) bias. The Anode Switched Thyristor (AST) turn-off mode is demonstrated at a maximum cathode voltage of 3600 V and 14.5 A (199 A/cm 2 ) of cathode current. A cathode current of 5.5 A (75 A/cm 2 ) is successfully turned off by the gate turn off (GTO) or hard turn-off mode at different temperatures up to 200°C. The high-level lifetime (t HL ) in the thick p-layer is extracted from the hard turn-off waveforms.
O BARROCO DE VELÁZQUEZ (2014)

This article aims to do iconographic analysis of Apollo in the Forge of Vulcan painting by Diego Velazquez. Artist of the brightest of his time, Velazquez constructs a visual narrative from classical texts known to him on his journey to Rome in 1629. That canvas is significant for understanding the space of Painter's time, i.e., the modern era, when virtuoso was sponsored by Spanish State, through the figure of monarch Philip IV, Philip II' grandson. Although the scene is inspired by Greek mythology texts, there are references of his time painted in the image. We intend, as primary goal, divulge Velazquez's pictures beyond the most known. Methodology relies mainly on readings from art experts such as E. H. Gombrich and Jonathan Brown. We follow iconographic analysis model founded by art researcher Erwin Panofsky.
Massively parallel VLSI-implementation of a dedicated neural network for anomaly detection in automated visual quality control (2002)

In this work we will present the VLSI-implementation of a dedicated neural network architecture which we have developed in prior work for anomaly detection in automated visual industrial quality control. The network, denoted as NOVAS performs a filtering of inspection images and highlights defects or anomalies in an isomorphic image representation, allowing the detection and localisation of faults on objects. Training of NOVAS is achieved by simply presenting a set of tolerable objects to the network in a single sweep. NOVAS works with single and with multichannel image representations. The processing principle of NOVAS is closely related to nearest neighbor and hypersphere classifier approaches. We have designed an ASIC for the efficient implementation of the nearest neighbor search. Based on that ASIC we will present an architecture of a modular massively parallel computer suited to meet the real-time constraints of manufacturing processes. Further we will report on the status of a prototype system which is close to completion.