gebhart/patrepeval huggingface dataset:
Rifabutin‐based Helicobacter pylori eradication ‘rescue therapy’ (2001)

SIRS, We read with interest the work by Perri et al. on the efficacy of a rifabutin-based Helicobacter pylori eradication regimen in patients who remained positive after three or more courses of 7-day standard therapies.1 In order to verify rifabutin efficacy and tolerability, we carried out a 10-day trial with the following regimen: omeprazole (20 mg b.d.), amoxicillin (1 g b.d.), rifabutin (300 mg o.m.). All 10 patients (7 male, mean age 36 years) had multiple unsuccessful eradication attempts, and agreed to be submitted to the therapy. We obtained good eradication rates: 77% of patients (7/9) by per protocol analysis and 70% by intention-to-treat analysis (7/10). However, one patient withdrew after 6 days of therapy: he developed fever with a severe leukopenia and trombocytopenia that continued for several days after discontinuation of rifabutin. His absolute WBC count fell below 2000/mm3, and his platelet count fell below 100 000/mm3 at day 7. His bone marrow aspirate indicated that neutropenia was a result of myelotoxicity. His white blood cell count returned to normal at day 15 after discontinuation of therapy. Our results confirm the efficacy of rifabutin in eradicating H. pylori in patients ‘resistant’ to standard regimens, nevertheless physicians should be aware of the risk of major side-effects arising during a rifabutin-based regimen. The myelotoxicity of rifabutin has been described during longer exposure (> 10 days) and at a higher dosage (> 600 mg/day).2, 3 Important drug interactions with commonly-used antibiotics can also be speculated—for example, with clarithromycin in combination therapy, because rifabutin induces cytochrome P-450.4 Finally, since the Italian Ministry of Health and the FDA indications for the use of rifabutin are restricted to prevention or cure of Mycobacterium avium complex disease in HIV-infected patients, the use of this drug outside this indication is questionable.
Randomized, Double-Blind, Multicenter Study of the Endeavor Zotarolimus-Eluting Phosphorylcholine-Encapsulated Stent for Treatment of Native Coronary Artery Lesions (2006)

Compared with bare metal stents, the Endeavor stent is safe and reduces the rates of clinical and angiographic restenosis at 9, 12, and 24 months.
The Ultrastructure of the Heart in Systole and Diastole (1967)

The relations between ultrastructure and function have been examined in the canine left ventricle under known hemodynamic conditions. Left ventricles of normal dogs were fixed acutely by rapid perfusions of the coronary arteries in either diastole or systole, and also following acute ventricular distension, or potentiation of contraction. Sarcomere lengths at the midwall of the left ventricle averaged 2.07 µ at end diastole and 1.81 µ at end systole, changes that are adequate to explain the degree of normal ventricular emptying. Following marked ventricular emptying induced by postextrasystolic potentiation, sarcomeres shortened to an average of 1.60 µ; with acute ventricular distension resulting from over-transfusion, average sarcomere length in diastole increased to 2.25 µ. In each instance, sarcomere lengths correlated with the changes in sarcomere length predicted from changes in the dimensions of a thick-walled sphere. The importance of dispersion of sarcomere length within a given layer of the ventricular wall was noted and its potential significance discussed.
A thin-membrane surface-acoustic-wave vapor-sensing device (1982)

An integrated silicon-based vapor sensor is realized with a ZnO-on-Si surface-acoustic-wave (SAW) oscillator containing an absorptive polymer located on a thinned, membrane region of the device. If the membrane thickness is comparable with or smaller than a SAW wavelength, wave energy is present at both membrane surfaces. Thus the SAW transducers and associated amplifiers can be protected by an enclosure, leaving only the polymer exposed to the ambient atmosphere. Experiments on a 30 MHz, ZnO-on-silicon thin-membrane temperature-compensated SAW oscillator for vapor sensing are described. The use of the multi-channel device for solubility parameter sensing is discussed.
Thickness determination of semitransparent isolated solids using the flash method and an analytical model (2016)

As groundwork for thickness determination of polymeric surface protection systems for concrete, we present a method for measuring the thickness of isolated semitransparent solids using pulse thermography both in transmission and reflection geometry. Since standard models [1] do not capture semitransparency, an advanced analytical model by Salazar et al. Physical material parameters are deduced by fitting experimental data from samples of wellknown thickness. Using those, the thickness of samples of the material can be obtained by fitting, as demonstrated for different semitransparent polymer materials.
Analysis of Arabidopsis thioredoxin-h isotypes identifies discrete domains that confer specific structural and functional properties (2013)

Multiple isoforms of Arabidopsis thaliana h-type thioredoxins (AtTrx-hs) have distinct structural and functional specificities. AtTrx-h3 acts as both a disulfide reductase and as a molecular chaperone. We prepared five representative AtTrx-hs and compared their protein structures and disulfide reductase and molecular chaperone activities. AtTrx-h2 with an N-terminal extension exhibited distinct functional properties with respect to other AtTrx-hs. AtTrx-h2 formed low-molecular-mass structures and exhibited only disulfide reductase activity, whereas the other AtTrx-h isoforms formed high-molecular-mass complexes and displayed both disulfide reductase and molecular chaperone activities. The domains that determine the unique structural and functional properties of each AtTrx-hs protein were determined by constructing a domain-swap between the N- and C-terminal regions of AtTrx-h2 and AtTrx-h3 (designated AtTrx-h-2N3C and AtTrx-h-3N2C respectively), an N-terminal deletion mutant of AtTrx-h2 [AtTrx-h2-N(∆19)] and site-directed mutagenesis of AtTrx-h3. AtTrx-h2-N(∆19) and AtTrx-h-3N2C exhibited similar properties to those of AtTrx-h2, but AtTrx-h-2N3C behaved more like AtTrx-h3, suggesting that the structural and functional specificities of AtTrx-hs are determined by their C-terminal regions. Hydrophobicity profiling and molecular modelling revealed that Ala100 and Ala106 in AtTrx-h3 play critical roles in its structural and functional regulation. When these two residues in AtTrx-h3 were replaced with lysine, AtTrx-h3 functioned like AtTrx-h2. The chaperone function of AtTrx-hs conferred enhanced heat-shock-resistance on a thermosensitive trx1/2-null yeast mutant.
Imaging and fold comparison of mirror reverse time migration vs. interferometric imaging for VSP data (2022)

It is well known that VSP data migration using only primary reflections has limited illumination. Mirror migration and interferometric imaging utilize free-surface multiples to extend the subsurface illumination. We design a 2-D synthetic model to examine VSP imaging strategies that use P-wave primaries or multiples. First, we show a ray-tracing method to approximate the fold density of a given VSP survey acquisition for imaging using primaries or free- surface multiples. The fold-density profile shows that imaging using free-surface multiples exhibits a lower fold- density but better lateral and vertical illumination than imaging using primaries alone. Next, we compare reverse time migration (RTM), mirror RTM imaging using up- going, down-going, and both wavefields, and imaging using seismic interferometry. We also examine the sensitivity of the different methods to the migration velocity model. When the exact velocity model is used, mirror RTM with both up- and down-going wavefields produces the best image with greater illumination. On the other hand, the image obtained from seismic interferometry is less sensitive to velocity errors.
Abstract 2385: Epidemiology of Incident Heart Failure in a Contemporary Elderly Population: The Health, Aging, and Body Composition (Health ABC) Study (2008)

Despite the increasing elderly population and rising heart failure (HF) burden, epidemiology of incident HF in the elderly is not well described. We studied 2934 elderly participants without prevalent HF enrolled in the Health ABC study (aged 73.6 ± 2.9 years, 47.9% men, 58.6% white, 41.6% black) and assessed incidence rates, population attributable risk (PAR) for independent risk factors, and outcomes of incident HF. After 7.1 year median follow-up, 258 (8.8%) participants developed HF requiring hospitalization (annual rate: 13.6 per 1000 participants). Men and blacks were more likely to develop HF than women and whites: annual rate was 16.3/1000 in blacks vs. 11.9/1000 in whites [hazard ratio (HR) 1.41, 95% confidence interval (CI), 1.11–1.80, p = 0.006]; and 15.8/1000 in men vs. 11.7/1000 in women (HR 1.34, 95% CI, 1.05–1.71, p = 0.021). Coronary heart disease and uncontrolled blood pressure had the highest PAR ( &gt; 20% each) both in whites and blacks (Table 1 ); a substantial proportion of incident HF was attributable to metabolic and cardio-renal risk factors. The fraction of incident HF cases attributable to modifiable risk factors was higher in blacks vs. whites (68% vs. 49%). No significant sex-based differences were observed in risk factors and PAR. Participants who developed HF had a considerably higher annual mortality than HF-free participants (18.0% vs. 2.7%). Survival after HF did not differ between whites and blacks; however, rehospitalization rates were two-fold higher in blacks compared to whites (62.1 vs. 30.3 per 100 patient-years, p &lt; 0.001), due to a higher rate of HF related readmissions in blacks. Incident HF is common in the elderly and is associated with poor outcomes. A large proportion of incident HF risk was attributed to modifiable risk factors. Significant racial differences in PAR for risk factors and hospitalization rates after incident HF need to be accounted for future prevention and treatment efforts. Table 1. Adjusted rate ratios and population attributable risk for the modifiable risk factors of incident heart failure in the Health ABC study
Autoinducer 2 Is Required for Biofilm Growth ofAggregatibacter(Actinobacillus)actinomycetemcomitans (2007)

Autoinducer 2 (AI-2) is required for the growth of Aggregatibacter (Actinobacillus) actinomycetemcomitans in culture under conditions of iron limitation. However, in vivo this organism thrives in a complex multispecies biofilm that forms in the human oral cavity. In this report, we show that adherent growth of A. actinomycetemcomitans on a saliva-coated surface, but not planktonic growth under iron-replete conditions, is defective in a LuxS-deficient background. Biofilm growth of the luxS mutant exhibited lower total biomass and lower biofilm depth than those for the wild-type strain. Normal biofilm growth of the luxS mutant was restored genetically by introduction of a functional copy of luxS and biochemically by addition of partially purified AI-2. Furthermore, introduction of S-adenosylhomocysteine hydrolase, which restores the metabolism of S-adenosylmethionine in the absence of LuxS, into A. actinomycetemcomitans did not complement the luxS mutation unless AI-2 was added in trans. This suggests that AI-2 itself is required for biofilm growth by A. actinomycetemcomitans. A biofilm growth deficiency similar to that of the LuxS-deficient strain was also observed when a gene encoding the AI-2-interacting protein RbsB or LsrB was inactivated. Biofilm formation by A. actinomycetemcomitans was virtually eliminated upon inactivation of both rbsB and lsrB. In addition, biofilm growth by wild-type A. actinomycetemcomitans was reduced in the presence of ribose, which competes with AI-2 for binding to RbsB. These results suggest that RbsB and LsrB function as AI-2 receptors in A. actinomycetemcomitans and that the development of A. actinomycetemcomitans biofilms requires AI-2.
Extremely large magnetoresistance in high-mobility SrNbO3/SrTiO3 heterostructures (2021)

An extremely large linear magnetoresistance (LMR) is a ubiquitous phenomenon emerging from topological Dirac and Weyl semimetals. However, the connection between an LMR and a nontrivial topology is under extensive debate. In this paper, by precisely controlling the thickness of ${\mathrm{SrNbO}}_{3}$ thin films grown on ${\mathrm{SrTiO}}_{3}$ substrates, we observe an LMR over a large carrier density range with a magnetoresistance as high as $150\phantom{\rule{0.16em}{0ex}}000%$ at a carrier density $n\ensuremath{\sim}{10}^{21}\phantom{\rule{0.28em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}3}$, far away from the quantum-limit regime. The temperature-, magnetic-field-, and carrier-density-dependent LMR in ${\mathrm{SrNbO}}_{3}/{\mathrm{SrTiO}}_{3}$ heterostructures provides compelling evidence of a mobility-driven LMR in coherent electronic systems. Our results uncover the general principle of an LMR and shed light on proper categorization of transport properties in topological and correlated materials.
Abstract 14948: Polymer-Free Biolimus A9-Coated Stents in the Treatment of De-Novo Coronary Lesions With Short DAPT: 9 Month Angiographic and Clinical Follow-Up of the Prospective, Multicenter BioFreedom USA Clinical Trial (2016)

Background: Biofreedom is a polymer-free and carrier-free drug-coated stent (DCS) that transfers biolimus A9, a highly lipophilic sirolimus analogue, into the vessel wall over a period of 1 month. The purpose of this study was to evaluate the efficacy and safety of this DCS in patients who received short duration (3 months) of dual antiplatelet therapy. Methods: The BioFreedom USA trial was an open-label single-arm study of patients requiring stenting of de-novo lesions. Patients received 3 months of dual antiplatelet therapy (DAPT), and were followed by repeat angiogram and clinically at 9 months. The primary efficacy endpoint, late lumen loss at 9 months, was compared to a historical control of the first generation paclitaxel drug eluting stents. The primary safety endpoint was the composite of cardiac death, myocardial infarction, target lesion revascularization or stent thrombosis (MACE) Results: A total of 72 patients from 10 sites had the BioFreedom DCS implanted in 83 lesions. Baseline characteristics included: mean age, 63.5+9.0 years, female gender, 20.8%, diabetes, 31.9%, patients with unstable angina 38.3%. At 1 month the proportion of patients taking DAPT was 96.8% and was 18.2% by 4 months. At 9 months 6.5% of patients were on DAPT. The 9-months (lesion n=66) late lumen loss in-stent was 0.32±0.53 mm (p=0.19), and in-segment was 0.34±0.51 mm. Twenty-five lesions were available for paired IVUS analyses between post-procedure and 9 months with low in-stent neointimal volume obstruction, 5.39% ± 5.28%, and a neointimal hyperplasia of 7.43 ± 8.04 (mm 3 ). At 9 months, the composite safety endpoint was 9.9%, and the target lesion revascularization was 2.9%. There was no definite/probable stent thrombosis. Conclusions: The Biofreedom DCS’s angiographic and IVUS follow-up demonstrated similar effectiveness to drug eluting stents and was superior to bare metallic-stents. Short DAPT of 3 months was safe without occurrence of stent thrombosis. The Biofreedom DCS may offer reasonable effectiveness and safety for stable patients who necessitate a shorter duration of DAPT. ClinicalTrials.gov number, NCT02131142
Supplementary Data 2 from Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen (2023)

Supplementary Data 2 from Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen
Biomarkers in Osteoarthritis (2012)

The future of OA biomarkers is great. The number of studies currently underway has increased greatly, including longitudinal studies. More research on new biomarkers is underway, and we hope to increase awareness and use of biochemical biomarkers over the next few years. The goal is clear—to move the diagnosis of OA from a radiologic viewpoint back to a pre-radiologic viewpoint and on to the molecular events that initiate cartilage breakdown and joint failure.
Syntheses of methoxyestrogen glucuronide acetate-methyl esters. (1976)

In connection with the studies on the metabolism of female hormone the title compounds having the 16, 17-ketol and -glycol structures were prepared as new and potential metabolites. These compounds were satisfactorily obtained from catechol estrogen 2- and 3-methyl ethers by Koenigs-Knorr reaction with methyl acetobromoglucuronate employing cadmium carbonate as a catalyst.
Case 13-2004 (2004)

A female infant was born with a large, dark-red cutaneous lesion covering much of her trunk. A platelet transfusion was followed by dramatic enlargement of the lesion.
Author response for "Lower Cardiorenal Risk with Sodium-Glucose Cotransporter-2 Inhibitors versus Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Patients without Cardiovascular and Renal Diseases: A large multinational observational study" (2020)

Lower cardiorenal risk withsodium-glucosecotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes without cardiovascular and renal diseases: A large multinational observational study
Prevention and Management of Cold-Weather Injuries (2005)

Soldiers participating in military deployments often encounter cold Stress that requires management for successful mission accomplishment. Excessive cold stress degrades physical performance capabilities, significantly impacts morale, and eventually causes cold casualties. Cold stress environments include not only exposure to extremely low temperatures, but also cold-wet exposures in warmer ambient temperatures. The purpose of this bulletin is to provide guidance to military and civilian health care providers, allied medical personnel, and unit commanders and leaders to develop an evidence-based prevention program to protect military personnel from cold stress and associated adverse health effects. The TB MED will enable individuals to: 1) understand the physiologic responses and adaptations to cold, 2) implement procedures for managing cold stress, 3) understand the principles and proper use of cold weather clothing, 4) understand the diagnosis and treatment of nonfreezing and freezing cold injuries and other medical conditions associated with cold weather, 5) identify the risk factors for cold injuries and implement treatment, and 6) prevent cold injuries during deployment and training.
Hardness assurance testing of bipolar junction transistors at elevated irradiation temperatures (1997)

The effect of dose rate on radiation-induced current gain degradation was quantified for radiation-hardened poly-Si emitter n-p-n bipolar transistors over the range of 0.005 to 294 rad(Si)/s. Degradation increases sharply with decreasing dose rate and saturates near 0.005 rad(Si)/s. The amount of degradation enhancement at low dose rates decreases monotonically with total dose. In addition, the effect of ambient temperature on radiation-induced gain degradation at 294 rad(Si)/s was investigated over the range of 25 to 240/spl deg/C. Degradation is enhanced with increasing temperature while simultaneously being moderated by in situ annealing, such that, for a given total dose, an optimum irradiation temperature for maximum degradation results. The optimum irradiation temperature decreases logarithmically with total dose and, for a given dose, is smaller than optimum temperatures reported previously for p-n-p devices. High dose rate irradiation at elevated temperatures is less effective at simulating low dose rate degradation for the n-p-n transistor than for the p-n-p transistors. However, additional degradation of the n-p-n device at elevated temperatures is easily obtained using overtest. Differences in the radiation responses of the device types are attributed to the relative effects of oxide trapped charge on gain degradation. High dose rate irradiation near 125/spl deg/C is found to be suitable for the hardness assurance testing of these devices provided a design margin of at least two is employed.
Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH 2 -terminal Kinase (JNK/SAPK) (2021)

Paclitaxel (Taxol) is a novel anti-cancer drug that has shown efficacy toward several malignant tumors, particularly ovarian tumors. We reported previously that paclitaxel can induce interleukin (IL)-8 promoter activation in subgroups of ovarian cancer through the activation of both AP-1 and nuclear factor kappaB. Further analysis of paclitaxel analogs indicates that the degree of IL-8 induction by analysis correlates with the extent of cell death; however, IL-8 itself is not the cause of cell death. This suggests that pathways that lead to IL-8 and cell death may overlap, although IL-8 per se does not kill tumor cells. To decipher the upstream signals for paclitaxel-induced transcriptional activation and cell death, we studied the involvement of protein kinases that lead to the activation of AP-1, specifically the c-Jun NH2-terminal kinase (JNK1), p38, and the extracellular signal-regulated kinase 1 (ERK1). The role of IkappaB in paclitaxel-induced cell death was also analyzed. Paclitaxel activated JNK, and to a lesser degree p38, but not ERK1. Paclitaxel-induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha, but not by dominant-inhibitory forms of ERK1. Dominant-inhibitory mutants of JNK1 also greatly reduced paclitaxel-induced cell death, and the kinetics of JNK induction was closely followed by DNA fragmentation. These results indicate (i) that paclitaxel activates the JNK signaling pathway and (ii) that JNK activation is a common point of paclitaxel-induced gene induction and cell death.
Materials Considerations for Supercritical CO2 Turbine Cycles (2013)

Proposed open and closed Brayton-type cycle systems employing supercritical CO2 (sCO2) as the working fluid develop hot gas path environments that present challenging requirements of strength and environmental resistance for the materials of construction. The likely materials properties required by different cycle configurations are examined and compared with the capabilities of available materials. In some instances where peak operating conditions in the turbines in closed-cycle systems approach 500°–700°C at 200 bar, or 1150°C at 300 bar for open cycles, the range of available alloys with the requisite temperature-strength and capabilities is limited. The cycles are highly recuperated: hot, lower-pressure turbine exhaust is used to pre-heat high-pressure CO2 entering the external heater or combustor just upstream of the turbine. Obviously, there is a need to match alloy capabilities with the performance requirements of individual components. Where alloys are employed under conditions beyond current experience, or in unusual configurations (the unique properties of sCO2 may impact the design of some components), practical acceptance will depend on successful qualification testing involving close collaboration among equipment manufacturers, materials suppliers, and materials research and development groups. Examination of the range of scenarios published for sCO2 turbine systems suggests that approaches used in the U.S. Advanced, Ultra-Supercritical (A-USC) Steam Boiler program, and some of the data generated for fabrication, joining, mechanical properties, and performance in simulated service environments in that program, will be applicable to some of the components in these systems. An attempt to elaborate and prioritize the materials property and qualification activities required for the successful realization of these sCO2 cycles is presented as a guide to activities needed to facilitate materials selection.