gebhart/patrepeval huggingface dataset:
Differential regulation of iron homeostasis during human macrophage polarized activation (2009)

Iron metabolism in inflammation has been mostly characterized in macrophages exposed to pathogens or inflammatory conditions, mimicked by the combined action of LPS and IFN-gamma (M1 polarization). However, macrophages can undergo an alternative type of activation stimulated by Th2 cytokines, and acquire a role in cell growth and tissue repair control (M2 polarization). We characterized the expression of genes related to iron homeostasis in fully differentiated unpolarized (M0), M1 and M2 human macrophages. The molecular signature of the M1 macrophages showed changes in gene expression (ferroportin repression and H ferritin induction) that favour iron sequestration in the reticuloendothelial system, a hallmark of inflammatory disorders, whereas the M2 macrophages had an expression profile (ferroportin upregulation and the downregulation of H ferritin and heme oxygenase) that enhanced iron release. The conditioned media from M2 macrophages promoted cell proliferation more efficiently than those of M1 cells and the effect was blunted by iron chelation. The role of ferroportin-mediated iron release was demonstrated by the absence of differences from the media of macrophages of a patient with loss of function ferroportin mutation. The distinct regulation of iron homeostasis in M2 macrophages provides insights into their role under pathophysiological conditions.
Designing Vision Systems For Robotic Applications (1989)

Intelligent robotic systems utilize sensory information to perceive the nature of their work environment. Of the many sensor modalities, vision is recognized a one of the most important and cost-effective sensors utilized in practical systems. In this paper, we address the problem of designing vision systems to perform a variety of robotic inspection and manipulation tasks. We describe the nature and characteristics of the robotic task domain and discuss the computational hierarchy governing the process of scene interpretation. We also present a case study illustrating the design of a specific vision system developed for performing inspection and manipulation tasks associated with a control panel.
Nitrene. II. Conversion of 1-(2-nitrobenzyl)isoquinoline derivatives into benz[a]carbazoles through nitrene (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrene. II. Conversion of 1-(2-nitrobenzyl)isoquinoline derivatives into benz[a]carbazoles through nitreneTetsuji Kametani, T. Yamanaka, and Kunio OgasawaraCite this: J. Org. Chem. 1968, 33, 12, 4446–4447Publication Date (Print):December 1, 1968Publication History Published online1 May 2002Published inissue 1 December 1968https://pubs.acs.org/doi/10.1021/jo01276a030https://doi.org/10.1021/jo01276a030research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
4,5-Dihydrobenzo[a]pyrene-4,5-trans-(e,e)-diol (1995)

The title compound, C20H14O2, is a metabolite of the chemical carcinogen benzo[a]pyrene. The crystal structure consists of groups of molecules in each of which both hydroxy groups donate and accept hydrogen bonds. Stacking of dihydrobenzo[a]pyrene ring systems occurs along the crystallographic c axis.
Assessment of arterial compliance in hypertension (1993)

Traditionally, hypertension has been defined in terms of an elevated resistance to flow confined predominantly to the precapillary vasculature. More recently, changes in arterial compliance have been used to estimate vascular adaptations in the larger conduit arteries. This review outlines and updates the many varied techniques employed to estimate arterial compliance changes during hypertension. Most measures of compliance assess changes in small segments of the arterial vasculature. Because hypertension is a disease that influences structure and reactivity in all parts of the systemic circulation, it is desirable that clinical techniques for monitoring vascular adaptations with disease should address the generalized changes in the systemic vasculature.
Development and Calibration of Differential Mobility Analyzer for 20 to 80 nm Particles Under Low Pressure Conditions (2011)

The vienna-type differential mobility analyzer (DMA) was developed for the measurement of wide-range nm-sized particles under low-pressure conditions (2.9-8 kPa) with the faraday cup electrometer (FCE). The length, inner and outer diameter of DMA are calculated as a function of flow rate, applied voltage, pressure, and particle diameter to avoide breakdown in DMA. The algorithm for the diffusion transfer function of the DMA was successfully developed and verified by comparing the numerical and experimental results. The DMA was calibrated via the tandem DMA (TDMA) method which using two DMA in parallel. The inversion algorithm was applied to the size distribution obtained from the current of the FCE. The calibration experiment was performed with 1% NaCl particles under atmospheric and low-pressure conditions. The calibration result showed that the development of the DMA was successful as it was able to measure 20- to 80-nm paricles under low-pressure conditions with various flow rates (0.1-0.5 l/min).
Recruitment of heterochromatin protein 1 to DNA repair sites (2009)

Heterochromatin protein 1 (HP1) was originally identified as a constitutive component of heterochromatin. However it is recognized now that it plays an important role in a number of dynamic processes in the cell nucleus, including transcriptional repression and regulation of euchromatic genes. Recent reports demonstrate that HP1 may be involved in the DNA damage response. Two seemingly contradictory phenomena have been observed-HP1 detachment from chromatin and HP1 recruitment to damaged DNA foci. Based on quantitative FRAP and FLIP studies carefully designed to minimize phototoxicity, we demonstrate that HP1 is recruited to the damaged regions in hetero- as well as euchromatin within a few minutes after damage.
Use of a high-molecular-weight carboxymethylcellulose in a tissue protective solution for prevention of postoperative abdominal adhesions in ponies (2002)

Intra-abdominal use of 1% HMW CMC during surgery was effective for preventing postoperative adhesions in ponies. Use of HMW CMC did not have detrimental effects on wound healing, intra-abdominal defenses, or patient health. A 1% solution of HMW CMC may be used routinely during abdominal surgery of horses for prevention of postoperative adhesions.
Poly(hydroxyalkanoates): Production, Applications and End-of-Life Strategies–Life Cycle Assessment Nexus (2022)

The runaway production and consumption of oil-based plastics are key drivers of global warming and the increased carbon footprint. Besides, most of this plastic debris ends up in the oceans and constitutes about 80% of all marine debris. This pollution problem calls for a seismic shift to eco-friendly plastics and marine biodegradable ones. Unlike other biobased polymers, polyhydroxyalkanoates (PHAs) take pride in their degradation in soil and marine environments. This intriguing marine biodegradation property of PHAs sets it apart as the best choice to curb microplastics, particularly in marine ecosystems. PHAs have also grown in popularity due to other quintessential properties such as biocompatibility, structural variety, and similarity to conventional plastics in terms of physical properties. PHAs are being widely researched for various applications, including packaging, medical, energy, and agriculture. This perspective comprehensively focuses on the state-of-art production and applications of PHA plastics as well as the practical recycling strategies for postconsumer PHAs. The innovative “next generation industrial biotechnology” (NGIB) is well covered in this perspective. Moreover, the nexus between end-of-life strategies and life cycle assessment (LCA) of PHAs waste is elucidated to understand its impact on the environment thoroughly.
Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease (2019)

Increased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.
Perfusion magnetic resonance abnormalities in patients with sickle cell disease (2001)

Neurological complications are common in sickle cell disease (SCD). However, it is often difficult to relate the clinical presentation to conventional neuroimaging, because subclinical infarction is common and stroke has been described in the absence of large-vessel disease. We studied 48 patients with SCD aged 4–34 (median 13) years with T2-weighted, diffusion and perfusion magnetic resonance imaging (MRI) and with MR angiography. Forty-four underwent transcranial Doppler (TCD). Abnormalities on perfusion imaging were seen in 25 cases, 24 of whom had been symptomatic. The remaining patient had evidence of executive dysfunction and reduced perfusion in the frontal lobes. The perfusion abnormality was larger than the area of infarction in 9 patients and was seen in an arterial distribution with no infarction in a further 9. In 3 patients with transient ischemic attacks, perfusion abnormalities were demonstrated in the absence of any other neuroimaging abnormalities, and perfusion changes were seen in 3 others despite normal MR angiography and TCD. Perfusion abnormalities are associated with neurological symptoms in patients with SCD, whether or not MRI, MR angiography, and TCD are abnormal. It is likely that this technique will guide management in individual patients. Ann Neurol 2001;49:477–485
Experience of maintaining tooth brushing for children born with a cleft lip and/or palate (2017)

The paper suggests that parents of children with a CL/P need support to enact their intention to maintain regular tooth brushing and prioritise tooth brushing within the context of demanding and dynamic family life.
Pneumatic fracturing to remove VOCS (1991)

Abstract A new process for enhancing in‐situ remediation of low‐permeability soil and rock formations is presently under development at the Hazardous Substance Management Research Center (HSMRC). The patented process, known as „pneumatic fracturing,”︁ consists of injecting high‐pressure air or other gas into contaminated geologic formations at controlled flow rates and pressures. In fine‐grained soils such as clay, pneumatic fracturing creates conductive channels in the formation, thereby increasing the permeability and exposed surface area of the contaminated soil. The potential benefits of pneumatic fracturing are significant, since in‐situ remedial technologies are essentially limited by the pore gas exchange rate of the soil being treated. This article describes the results of a recent demonstration of pneumatic fracturing at an industrial site to enhance a volatile organic compound (VOC) extraction system. After establishing the baseline removal rate of soil gas effluent from the clay, soil surrounding the extraction system was fractured to enhance VOC with drawal. A substantial improvement in the VOC removal rate was observed, including: (1) flush effluent concentrations that increased up to 200 times; and (2) air flows in the formation that increased up to 1,000 times.
Fabrication of Pt/Sr 2 (Ta 1-x ,Nb x ) 2 O 7 /SiO 2 /Si field-effect transistor for one-transistor-type ferroelectric random access memory (2007)

Sr2(Ta1-x,Nbx)2O7 (STN; x=0.3) is one of the most practical candidates for one-transistor-type ferroelectric random access memory devices. One of the most typical structures for the devices is metal-ferroelectric-insulator-semiconductor (MFIS) structure. However, the fabrication of STN on an amorphous SiO2 (insulator) is difficult. In particular, in the case of STN, because its crystallization annealing temperature is 950°C, the metal elements of STN and Si react with each other during crystallization annealing. As a result, perovskite STN cannot be fabricated. We have already developed STN film formation technologies on SiO2 by ion-bombardment-assisted sputtering and introducing a thin STN seed layer treated by oxygen radicals using a microwave-excited plasma system. The IrO2/perovskite STN (140 nm)/STN seed layer (10 nm)/SiO2 (10 nm)/Si device shows square hysteresis curves and a memory window of 1.7 V under an 8 V writing operation. Furthermore, we have fabricated and operated the Pt/STN (140 nm)/STN seed layer (10 nm)/SiO2/Si field-effect transistor for the first time. The drain current (Id)-gate voltage (Vd) [Id-Vg] characteristics show counterclockwise hysteresis curves due to ferroelectric polarization switching.
Acyl-Coenzyme A—Cholesterol Acyltransferase Activity in Human Liver (1979)

1. In the presence of CoA and ATP, human liver microsomes catalyse the incorporation of [14C]oleate or [14C]cholesterol into cholesteryl oleate, thus demonstrating the presence of acyl-coenzyme A-cholesterol acyltransferase (cholesterol acyltransferase) in human liver. 2. The enzyme has properties similar to those of rat liver enzyme and with both the concentration of endogenous cholesterol in the microsomal fraction is adequate to support a constant initial rate of esterification. However, unlike the rat liver enzyme, the human cholesterol acyltransferase does not efficiently utilize added cholesterol as substrate. 3. The activity of cholesterol acyltransferase in human liver was 25% of that measured in rat liver under similar conditions of assay.
Large eddy simulation of the near wake of a rectangular wing (1998)

A model of the initial conditions in the near wake of a rectangular wing is devised to investigate mechanisms of turbulence production in the spiral wake around the core of a tip vortex. The model consists of a streamwise vortex sheet whose strength is found from Prandtl lifting line theory. Spanwise vorticity is represented by a Gaussian streamwise velocity profile that is superimposed on the field of the vortex sheet. The integrated spanwise vorticity of this profile is zero. The model is then used to initialize the flow field for temporal large-eddy simulation of the instabilities of the spanwise vorticity during roll up. The results show that the sinuous mode prevails in the spiral wake around the core. The strength and streamwise length scale of the instability vary along the wake because of the continuous variation in its thickness. The large scale structures produced by the instability of the spiral wake cause the formation of undulations on the core consistent with the hypothesis of Devenport et al. (1996).
Comparative performance of anaerobic filters at mesophilic and thermophilic temperatures (1993)

ABSTRACT: Anaerobic filters were operated at mesophilic and thermophilic temperatures with hydraulic retention times (HRTs) of 12, 24, and 48 hours over a COD loading range from 2.75 g/L/day to 49.5 g/L/day (172 to 3090 lb/1000 cu ft/day). The purpose of the research was to determine the effect of HRT and organic (COD) loading as independent variables. Results indicated that the mesophilic systems were more sensitive to HRT than were the thermophilic systems, with significant decreases in performance of the mesophilic systems with decreases in HRT. The thermophilic reactors showed virtually no reduction in performance with decreased HRT. The increase in organic load produced a reduction in removal efficiency at all HRTs for the mesophilic reactors. The effect of organic load was more significant at the lower HRTs for the mesophilic reactors. The thermophilic units, on the other hand, displayed a reduction in chemical oxygen demand (COD) only at the high loadings while at an HRT of 48 hours. The increase in loadings showed little effect at the lower HRTs (24 and 12 hours) when the systems were able to flush the inhibitory substances from the reactors. Overall, the thermophilic systems were able to treat the waste at more than twice the COD loading rate of the mesophilic systems.
Entanglement transfer from electron spins to photons (2004)

We show that electron recombination in spin light-emitting diodes provides an efficient method to transfer entanglement from electron spins onto pairs of polarization-entangled photons. Because of the interplay of quantum mechanical selection rules and interference, maximally entangled electron pairs are converted into maximally entangled photon pairs with unity fidelity for a continuous set of observation directions. We describe the dynamics of the conversion process using a master-equation approach and show that the implementation of our scheme is feasible with current experimental techniques.
Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis (2018)

The radiological severity of disease on chest x-ray prior to treatment in smear positive pulmonary TB patients is weakly associated with the bacterial burden. When compared against other variables at diagnosis, this effect is lost in those without cavitation. Radiological severity does reflect the overall disease severity in smear positive pulmonary TB, but we suggest that clinicians should be cautious in over-interpreting the significance of radiological disease extent at diagnosis.
Compatibilization Effect of Poly(ε-caprolactone)-b-poly(ethylene glycol) Block Copolymers and Phase Morphology Analysis in Immiscible Poly(lactide)/Poly(ε-caprolactone) Blends (2002)

The miscibility and phase behavior of two stereoisomer forms of poly(lactide) (PLA: poly (L-lactide) (PLLA) and poly(DL-lactide) (PDLLA)) blends with poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) and PCL-b-monomethoxy-PEG (PCL-b-MPEG) block copolymers have been investigated by differential scanning calorimetry (DSC). The DSC thermal behavior of both the blend systems revealed that PLA is miscible with the PEG segment phase of PCL-b-(M)PEG but is still immiscible with its PCL segment phase although PCL was block-copolymerized with PEG. On the basis of these results, PCL-b-PEG was added as a compatibilizer to PLA/PCL binary blends. The improvement in mechanical properties of PLA/PCL blends was achieved as anticipated upon the addition of PCL-b-PEG. In addition, atomic force microscopy (AFM) measurements have been performed in order to study the compositional synergism to be observed in mechanical tests. AFM observations of the morphological dependency on blend composition indicate that PLA/PCL blends are immiscible but compatible to some extent and that synergism of compatibilizing may be maximized in the compositional blend ratio before apparent phase separation and coarsening.
Crafting a 15  µm pixel pitch spatial light modulator using Ge2Sb2Te5 phase change material [Invited] (2019)

For this research, we have developed key technologies for a 1.5 µm pixel pitch spatial light modulator (SLM) using <i>G</i><i>e</i><sub>2</sub><i>S</i><i>b</i><sub>2</sub><i>T</i><i>e</i><sub>5</sub> (GST) phase change material. To uniformly modulate each pixel, we designed a lateral pixel structure in which a heating current flows through a bottom indium tin oxide layer. To check hologram reconstruction both after multilevel fabrication processes and before implementing full source and driver circuits, we fabricated an 8<i>K</i>×2<i>K</i> hologram on the topology by changing the GST film's phase using laser irradiation. To overcome the limitation of SLM size, we tested a physical tiling structure and found that flatness of tiled SLMs was the most important factor in the realization of holographic displays.
Experimental infection of mice with Listeria monocytogenes and L. innocua. (1981)

Swiss mice were infected with two Listeria strains: L. monocytogenes strain 10401, serovar 4b, and L. innocua strain 390, serovar 6a. Bacteria were inoculated by intravenous, subcutaneous or oral routes, and then enumerated in the spleen. The splenic infection was studied comparatively for these three inoculation routes with both strains. Strain 390 caused a splenic colonization only after intravenous inoculation. For the 10401 strain, the peak of infection appeared on the 3rd day after inoculation; the intravenous route was the most efficient to kill mice, the subcutaneous one the most efficient to obtain a reproductible sublethal infection; the oral route infected regularly only with doses higher than 10(7) bacteria. A splenomegaly appeared only in mice infected with strain 10401. Estimation of Listeria strain pathogenicity depended more on the measure of bacterial count in the spleen on the 3rd day of infection than on LD50. To be able to compare quantitatively the pathogenicity of L. monocytogenes and L. innocua, it seemed impossible to use only one dose of bacteria and to inoculate through one route.
Pharmacology of neuromuscular blocking agents and their reversal in trauma patients (2015)

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Experimental study of extruded powder metallurgy γ-TiAl based alloys (2019)

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A Thin-Film Gas Sensor Fabricated on a Diaphragm on a Silicon Substrate (1992)

A thin-film gas sensor was fabricated on an SiO2 diaphragm on an Si substrate. This sensor was composed of 2 parts; one was a gas-sensing part which had a semiconducting thin-film of an Fe2O3 based material, and the other was a heating part which had a metal thin-film with 3 layers of Cr/Pt+W/Cr. Both parts were fabricated on the same type of a diaphragm with thin-film and micromachining technologies, and were set face to face at a distance of 50μm.The heater was operated at 600°C by feeding 70mA of DC current. The voltage was 6.6V and the consumed power was 462mW. The gas sensing part was heated up to about 400°C. The conductance of the gas sensing part was about 0.05μS in a fresh air, whereas it was increased when H2 gas or i-C4H10 gas was introduced.The fabrication technologies of the sensor are compatible with those of ICs, and the sensor is apparently a small, light-weighted, and low power-consuming device. Moreover, it would be a promising device as an intelligent or smart sensor.