gebhart/patrepeval huggingface dataset:
A Quantitative Measurement of Bacteremia and Its Relationship to Plaque Control (1976)

Despite the improvement in the patients' oral hygiene, there was no significant decrease in the frequency of bacteremia. There was no significant difference in bacteremia between brushing, flossing, or deplaquing either before or after initial periodontal preparation and plaque control in 21 healthy subjects. Utilizing more sophisticated bacteriologic techniques for the cultivation of obligate anaerobes, a relatively high frequency of anaerobic bacteremia was found.
Towards Trusted Social Networks with Blockchain Technology (2018)

Large-scale rumor spreading could pose severe social and economic damages. The emergence of online social networks along with the new media can even make rumor spreading more severe. Effective control of rumor spreading is of theoretical and practical significance. This paper takes the first step to understand how the blockchain technology can help limit the spread of rumors. Specifically, we develop a new paradigm for social networks embedded with the blockchain technology, which employs decentralized contracts to motivate trust networks as well as secure information exchange contract. We design a blockchain-based sequential algorithm which utilizes virtual information credits for each peer-to-peer information exchange. We validate the effectiveness of the blockchain-enabled social network on limiting the rumor spreading. Simulation results validate our algorithm design in avoiding rapid and intense rumor spreading, and motivate better mechanism design for trusted social networks.
Mammalian HEMK1 Methylates Glutamine Residue of the GGQ Motif of Mitochondrial Release Factors (2021)

<title>Abstract</title> Despite limited reports on glutamine methylation, methylated glutamine is found to be highly conserved in a "GGQ" motif in both prokaryotes and eukaryotes. In bacteria, glutamine methylation of peptide chain release factors 1/2 (RF1/2) by the enzyme PrmC is essential for translational termination and transcript recycling. Two PrmC homologs, HEMK1 and HEMK2, are found in mammals. In contrast to those of HEMK2, the biochemical properties and biological significance of HEMK1 remain largely unknown. In this study, we demonstrated that HEMK1 is an active methyltransferase for the glutamine residue of the GGQ motif of all four putative mitochondrial release factors (mtRFs)—MTRF1, MTRF1L, MRPL58, and MTRFR. In HEMK1-deficient HeLa cells, GGQ motif glutamine methylation was absent in all the mtRFs. We examined cell growth and mitochondrial properties, but disruption of the HEMK1 gene had no considerable impact on the overall cell growth, mtDNA copy number, and mitochondrial membrane potential. Furthermore, mitochondrial protein synthesis was not affected in HEMK1 KO cells. Our results suggest that HEMK1 mediates the GGQ methylation of all four mtRFs in human cells; however, this specific modification seems mostly dispensable in cell growth and mitochondrial protein homeostasis under standard culture conditions.
Pore-scale model for fluid injection andin situgelation in porous media (1998)

We examine immiscible fluid displacement in a porous material for the case where a polymerization reaction occurs at the interface between two fluid phases. A three-dimensional sphere-based network model is used to study the process. An in situ reaction may affect the pore morphology, interfacial forces, or viscous forces, thereby altering the pressure distribution and displacement pattern. The amount and manner in which the displacement pattern is affected depends on competing rates of reaction versus convection. The model shows that at high-capillary-number displacements, a narrow range of reaction rates affects the displacement process, below which no effect is seen and above which the flow stops. As the capillary number decreases, this range widens but at the expense of the overall hydraulic conductivity. This phenomenon is explained using microscopic displacement patterns. An operating window can be drawn showing the flow and reaction domain in which one would expect an interfacial reaction of this type to affect fluid displacement.
Reversible Ipecac Myopathy (1985)

The abuse of ipecac syrup for three years resulted in painless, nonfatigable, chiefly proximal weakness in a 27-year-old woman. Electromyography (EMG) and a muscle biopsy revealed features of a myopathy similar to those previously reported in experimental emetine myopathy. Clinical weakness and EMG abnormalities improved after discontinuation of ipecac administration. A direct toxic action of ipecac (acting through its active alkaloid, emetine hydrochloride) on muscle fibers seemed to be responsible for the weakness in this patient.
The Biology of Osteoarthritis (1989)

OSTEOARTHRITIS, "an almost inevitable consequence of aging,"1 is second only to cardiovascular diseases in producing severe chronic disability, and it affects nearly 10 percent of the population over the age of 60.2 This prevalence and its costs — billions of dollars in medications, surgery, and days lost from work3 — account for the growing interest in uncovering the basic mechanisms by which this disease affects human joints.4 5 6 7 8 9 Osteoarthritis can involve axial, or spinal, as well as peripheral joints — those that bear weight (such as the hips and knees) as well as those that do not (such as the distal . . .
Association of physical activity with utilization of long-term care in community-dwelling older adults in Germany: results from the population-based KORA-Age observational study (2022)

The GNPAR are rarely met by older adults. However, doing any type of PA is associated with non-utilization of LTC in community-dwelling older adults. Therefore, older adults should be encouraged to walk or exercise regularly. Furthermore, future PA programs should consider target-groups' particularities to reach individuals with the highest needs for support.
An Efficient Inter-FPGA Routing Exploration Environment for Multi-FPGA Systems (2018)

Field programmable gate arrays (FPGAs) have seen a huge evolution since their inception almost three decades ago. Multi-FPGA boards continuously receive an increasing attention by the research community as efficient solutions for complex system prototyping. This is due to reliable high-speed, low-cost, and real-life exploration environment they offer. Although multi-FPGA platforms offer better frequency compared to other prototyping alternatives, expanding logic resource to I/O ratio in FPGAs is causing an increase in time multiplexing ratio of inter-FPGA signals (logical signals) to inter-FPGA tracks (physical resources), which causes a decline in overall system frequency. This paper introduces a generic testing platform for multi-FPGA modeling. With this platform, users will be able to experience overall prototyping cycle of a digital system. The cycle will start from benchmark generation and will go all the way to interFPGA routing. Using generic tools of this platform, we explore the effect of three different inter-FPGA routing approaches on the frequency of final prototyped design. Each routing approach is applied on generic as well as custom multi-FPGA boards. Results obtained through experimentation show that, for generic FPGA board, routing approach better exploiting two- and multi-point tracks of target FPGA board gives better average frequency results as compared to other two routing approaches.
Patterns of cerebral white matter damage and cognitive impairment in adolescents born very preterm (2008)

There is increasing evidence about the presence of white matter damage in subjects with a history of premature birth, even in those classified as good outcome because of an apparently normal development. Although intellectual performance is within normal limits in premature children it is significantly decreased compared to paired controls. The purpose of this study was to investigate the relationship between a lower performance intelligence quotient and white matter damage in preterm adolescents. The sample comprised 44 adolescents (mean age+/-S.D.: 14.4+/-1.6 years) born before 32 weeks of gestational age and 43 term-born adolescents (14.5+/-2.1 years). Individual voxel-based morphometry analyses demonstrated that 35/44 (80%) preterm subjects had white matter abnormalities. The centrum semiovale and the posterior periventricular regions were the most frequently affected areas. Correlation analysis showed that in preterms the performance intelligence quotient correlated with the whole-brain white matter volume (r=0.32; P=0.036) but not with grey matter volume. Complementary analysis showed that low scores in the Digit Symbol subtest, a measure of processing speed, in the preterm group correlated with reductions in white matter concentration. These results suggest that white matter damage is highly common and that it persists until adolescence. Hence, diffuse white matter loss may be responsible for performance intelligence quotient and processing speed decrements in subjects with very preterm birth.
CD44-Hyaluronate Interaction Participates in the Adherence of T-lymphocytes to Gingival Fibroblasts (1996)

It has already been clarified that peripheral blood T-lymphocytes which had been activated with phorbol 12-myristate 13-acetate (PMA) acquired the ability to bind to human gingival fibroblasts (HGF) and that the adherence was mediated by VLA integrins. However, these studies also raised the possibility that molecules other than VLA integrins should be involved in the adherence between T-lymphocytes and HGF. In this study, the possible involvement of CD44, a hyaluronate receptor, in heterotypic cell-cell interactions was investigated. It was confirmed that PMA-activated T-lymphocytes strongly adhered to plate-coated hyaluronate and that the hyaluronate binding was clearly inhibited by the addition of OS/37, a newly established mAb specific for the hyaluronate-binding epitope on CD44. Interestingly, OS/37 also blocked the HGF binding of the activated T-lymphocytes when the adherence to HGF was assessed at 4 degrees C, at which temperature the adhesion of integrin molecules diminished, while that of CD44 functioned normally. Immunofluorescence staining revealed that hyaluronate was anchored along the cell surface of HGF. Furthermore, the binding of activated T-lymphocytes to HGF was significantly inhibited by the treatment of HGF with hyaluronidase. These results clearly demonstrated that CD44-hyaluronate interactions participated at least in part in the adhesiveness of T-lymphocytes to HGF.
Adaptive meshfree approximation for linear elliptic partial differential equations with PDE-greedy kernel methods (2022)

We consider meshless approximation for solutions of boundary value problems (BVPs) of elliptic Partial Differential Equations (PDEs) via symmetric kernel collocation. We discuss the importance of the choice of the collocation points, in particular by using greedy kernel methods. We introduce a scale of PDE-greedy selection criteria that generalizes existing techniques, such as the PDE-$P$-greedy and the PDE-$f$-greedy rules for collocation point selection. For these greedy selection criteria we provide bounds on the approximation error in terms of the number of greedily selected points and analyze the corresponding convergence rates. This is achieved by a novel analysis of Kolmogorov widths of special sets of BVP point-evaluation functionals. Especially, we prove that target-data dependent algorithms that make use of the right hand side functions of the BVP exhibit faster convergence rates than the target-data independent PDE-$P$-greedy. The convergence rate of the PDE-$f$-greedy possesses a dimension independent rate, which makes it amenable to mitigate the curse of dimensionality. The advantages of these greedy algorithms are highlighted by numerical examples.
Laser materials processing and analytics in battery manufacturing – new design concepts and materials (2018)

Lithium-ion batteries suffer so far from high production costs, restricted process reliability, small energy and power density, and short operational lifetime. In order to overcome these drawbacks, laser materials processing is introduced in battery manufacturing in combination with advanced design rules and new electrode materials. Laser patterning of metallic current collectors and active material of thick film electrodes by laser-induced periodical surface structures (LIPSS) and direct laser ablation, respectively, is a research approach for the realization of three-dimensional (3D) electrode architectures that includes the ability of process up-scale and transfer of the 3D battery concept to lithium-ion cells with high energy and power. 3D electrode configurations result in improved high current capability of the cells compared to cells with conventional 2D electrodes due to increased active surface area, reduced mechanical stress during electrochemical charge/discharge cycles, and overall decreased cell impedance. Furthermore, laser generated micro-capillary structures turn composite electrodes into superwicking leading to a rapid and homogenous wetting with liquid electrolyte. This has a strong impact on battery lifetime and product homogeneity. The material and design concept is pushed beyond state-of-the-art by introducing high film thicknesses, and high energy materials such as nickel-enriched NMC cathodes and silicon/carbon anodes. Post mortem analysis by laser-induced breakdown spectroscopy (LIBS) was discovered as a versatile tool for optimizing coating processes and 3D electrode design concept. Binder distribution and lithium mapping along the whole electrode can be visualized. Laser generated 3D architectures act as an attractor for lithium-ions and boost the battery performance at high charging/discharging rate. A variation in porosity in thick film composite electrodes was identified as one of the main driving factors for cell degradation proving that structuring of electrodes by laser ablation cannot be replaced by embossing or structured rolls during calendering process.
Bandwidth Choice for Average Derivative Estimation (1992)

The average derivative is the expected value of the derivative of a regression function. Kernel methods have been proposed as a means of estimating this quantity. The problem of bandwidth selection for these kernel estimators is addressed here. Asymptotic representations are found for the variance and squared bias. These are compared with each other to find an insightful representation for a bandwidth optimizing terms of lower order than n-1. It is interesting that, for dimensions greater than 1, negative kernels have to be used to prevent domination of bias terms in the asymptotic expression of the mean squared error. The extent to which the theoretical conclusions apply in practice is investigated in an economical example related to the so-called "law of demand."
The Synthesis Of Epr Differentiable Spinlabels And Their Coupling To Uridine (2007)

For EPR measurements of RNA, DNA, or proteins, the occurrence of the paramagnetic species is necessary. The aim of this work is to improve the synthesis of two different EPR spinlabels 2,2,6,6-tetra methyl-3,4-dehydro-piperidin-N-oxyl-4-acetylene (TEMPA) 6 and 15N-labeled TEMPA 6* and their coupling to uridine. The yield of the synthesis of TEMPA could be increased to 40% and the second nitroxide 2,2,6,6-tetramethyl-3,4-dehydro-piperidin-15N-oxyl-4-acetylene 6* could be synthesized with a yield of 11%.
The selfish brain: energy shift during hypoglycemia (2006)

Objectives: The capacity of the brain to store energy is rather limited, wherefore the energy content in form of adenosine triphosphate (ATP) is regulated in extremely narrow confines. Based on a new paradigm for the regulation of energy allocation within the organism ('selfish brain'), we hypothesized that during energy restriction, the brain prioritizes adjustment of its own ATP concentration at the expense of peripheral organs
BMP-2 Dose-Response and Release Studies in Functionally Graded HAp (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Effect of dipeptidyl peptidase‐4 inhibitors on complement activation (2020)

We demonstrated an inhibitory effect of DPP-4 inhibitors on the lectin pathway in vitro. The clinical relevance of this effect of DPP-4 inhibitors remains to be fully elucidated.
Observations and Opportunities for Deploying Virtual Reality for Passenger Boats (2018)

We identify difficulties and opportunities in using virtual reality on passenger boats. As part of a larger ecotourism study, we experimented with the use of virtual reality (VR) on a boat using a head mounted display. This paper gives an overview of the causes and current knowledge of motion sickness, and details our experience of using VR on a catamaran. While there may be some liMassachusetts Institute of Technologyations and challenges to overcome related to current hardware offerings, there are also opportunities in minimizing seasickness through visual distraction that are worth investigating further.
Sidewall Roughness in Si3N4 Waveguides Directly Measured by Atomic Force Microscopy (2017)

We have developed a robust method to measure side-wall-roughness of sub-micron feature waveguides using atomic-force-microscopy. We measure the side-wall-roughness of silicon-nitride waveguides patterned by DUV photolithography and compare results of two different etch chemistries.
Volatile Constituents of Valeriana hardwickii Wall. Root Oil from Arunachal Pradesh, Eastern Himalaya (2011)

The composition of the essential oil extracted from Valeriana hardwickii Wall. roots growing wild in Talle Valley of Arunachal Pradesh, Eastern Himalaya was analyzed by capillary GC and GC/MS. Thirty-one compounds representing 89.6% of the total oil were identified. The oil was found to be rich in sesquiterpenes from which oxygenated sesquiterpenes (25.7%). Methyl linoleate (21.1%) and Valeracetate (11.6%) were the major constituents present in the oil. Whereas, Bornyl acetate (11.2%) and α-Terpinyl acetate (4.7%) were the only oxygenated monoterpenes identified in the investigated sample. Essential oil and its constituents of V. hardwickii may be used as the substitute of highly traded Indian Valerian (V. jatamansi) and European V. officinalis.
Effect of Process Parameters on Microstructure of TiAl Alloy Produced by Electron Beam Selective Melting (2014)

Pre-alloyed Ti-47Al-2Cr-2Nb powder was utilized to fabricate samples via electron beam selective melting. The microstructures of as-built components were characterized by optical microscopy, scanning microscopy and X-ray diffraction, while an electronic dispersive spectrometer was employed to study the chemical compositions. It is worth noting that the atomic percentage of aluminium decreased along with the increase of energy input. There appeared to be an element loss of aluminium up to 15% at the highest energy input. The microstructures consisted of lamellar α2-Ti3Al)/γ-TiAl, basket-weave α2 (Ti3Al) and B2 phase. With varied melting beam currents, different phase transformations resulted from different thermal cycles and varied element losses of aluminium. γ-TiAl was the main phase of Sample-1 with the lowest energy input, while α2-Ti3Al was the main phase of Sample-4 with the highest energy input. The thickness of lamellar α2 decreased as the cooling rate increased due to the increasing energy input.
Call for Papers: Nanoscale Integrated Photonics for Optical Networks (2006)

Call for Papers: Nanoscale Integrated Photonics for Optical Networks Keren Bergman, Coordinating Associate Editor Madeleine Glick, Guest Feature Editor Submission Deadline: 1 August 2006 Recent dramatic advances in nanoscale materials and nanophotonic device fabrication have yielded unprecedented control over the optical properties of synthetic structures. These extraordinary innovations at the nanoscale offer the possibility of creating high-functionality photonic devices in ultradense integration platforms. We can now envision nanoscale integrated photonics modules that may be application-specific designed in a similar fashion to integrated electronics for applications ranging from ultra-long-haul telecommunications to on-chip networks and high-performance computing. The applications of these advances to the transformation of optical networking is the theme of this Journal of Optical Networking (JON) feature issue. Scope of Submission The Editors of JON are soliciting papers on Nanoscale Integrated Photonics for Optical Networks. The aim in this feature issue is to publish original research on topics including--but not limited to--the following nanoscale materials and device fabrication as related to Novel optical network architectures Photonic switching fabrics and network elements Advances enabling new network functionalities such as novel solutions for optical buffering, packet or label processing, and routing modules Miniature mux/demux technology Application-specific design Integration and high-volume manufacture of photonics devices/modules Network interface and control planes Manuscript Submission To submit to this special issue, follow the normal procedure for submission to JON and select ``Integration' in the features indicator of the online submission form. For all other questions relating to this feature issue, please send an e-mail to jon@osa.org, subject line ``Integration.' Additional information can be found on the JON website: http://www.osa-jon.org/journal/jon/author.cfm. Submission Deadline: 1 August 2006
High-G Ruggedization Methods for Gun Projectile Electronics (1999)

Design and test methods are presented for ruggedizing
electronic assemblies to survive artillery gun fire G-forces.
Typical peak set-back accelerations for a 155 mm
gun projectile are 15,500 G’s with a 9 msec pulse
duration. Highly accurate guidance of artillery shells is
now possible due to size and cost reductions in GPS
receiver navigation electronics. Processes have been
developed to attach components for high rate production
at low cost. This report documents both GPS receiver
board and demonstration test vehicles designs. Presented
are the test program results including the successful
designs for MCM’s and crystal oscillators. IEC is a
proven leader in high-G electronics ruggedization. The
demand for miniaturized gun-hardened electronics will
greatly increase in the future to power the military’s
autonomous munitions. Test component selection and
design of experiment (DOE) testing are critical for a
successful high-G ruggedization project.