gebhart/patrepeval huggingface dataset:
Porous Silicon and Alumina as Chemically Reactive Templates for the Synthesis of Tubes and Wires of SnSe, Sn, and SnO2. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Physical and thermodynamic properties of pure chemicals: data compilation (1990)

Description of tables of property constants description of tables of equation coefficients synonyms list key for equation forms general references list of compound names.
Neutrinos from Stored Muons nuSTORM: Expression of Interest (2013)

The nuSTORM facility has been designed to deliver beams of electron and muon neutrinos from the decay of a stored muon beam with a central momentum of 3.8 GeV/c and a momentum spread of 10%. The facility is unique in that it will: serve the future long- and short-baseline neutrino-oscillation programmes by providing definitive measurements of electron-neutrino- and muon-neutrino-nucleus cross sections with percent-level precision; allow searches for sterile neutrinos of exquisite sensitivity to be carried out; and constitute the essential first step in the incremental development of muon accelerators as a powerful new technique for particle physics. Of the world's proton-accelerator laboratories, only CERN and FNAL have the infrastructure required to mount nuSTORM. Since no siting decision has yet been taken, the purpose of this Expression of Interest (EoI) is to request the resources required to: investigate in detail how nuSTORM could be implemented at CERN; and develop options for decisive European contributions to the nuSTORM facility and experimental programme wherever the facility is sited. The EoI defines a two-year programme culminating in the delivery of a Technical Design Report.
Fatigue strength of socket welded pipe joint (1995)

Fully reversed four point bending fatigue tests were carried out on small diameter socket welded joints made of carbon steels. Experimental parameters were pipe diameter, thicknesses of pipe and socket wall, throat depth and shape of fillet welds, slip-on and diametral gaps in the socket welding, lack of penetration at the root of fillet welds, and peening of fillet welds. In most cases a fatigue crack started from the root of the fillet, but in the case of higher stress amplitude, it tended to start from the toe of fillet. The standard socket welded joint for a pipe with a 50 mm nominal diameter showed a relatively low fatigue strength of 46 MPa in stress amplitude at the 10{sup 7} cycles failure life. This value corresponds to about 1/5 of that for the smoothed base metal specimens in axial fatigue. The fatigue strength decreased with increasing pipe diameter, and increased with increasing thickness of the pipe and socket wall. The effects of throat depth and shape of fillet welds on fatigue strength were not significant. Contrary to expectation, the fatigue strength of a socket welded joint without slip-on gap is Higher than that of the joint with a normal gap.more » A lack of penetration at the root deleteriously reduced fatigue strength, showing 14 MPa in stress amplitude at the 10{sup 7} cycles failure life for the 50 mm diameter socket joint.« less
Optimization of Experimental Parameters to the Formation of Bi2212 Phase via Sol-Gel Method (2011)

Bi-2212 superconducting phase was synthesized via sol-gel method, and the experimental parameters such as the concentration of precursor solution and heat treatment temperature were adjusted to find the optimal conditions. Metal nitrates were adopted as the starting materials and ethylenediaminetetracetic acid (EDTA) as chelating agent. Precursor solutions and gel with different concentration were obtained through the addition of different content of distilled water as solvent followed by heating at certain temperature to form grey powders. Afterwards, the powders were sintered at different temperature for 10 hours, respectively. X-ray diffraction (XRD) was adopted to investigate the phase purity and crystallinity of the sample derived. Results reveal that the optimized precursor solution concentration is 27% and the optimized sintering temperature is 850°C.
Internal 32P-labeling of L-deoxyoligonucleotides (2003)

A general two step procedure for the internal labeling of L-deoxyoligonucleotides, Spiegelmers, has been developed. Through radioactive labeling oligonucleotides can easily be detected and monitored in biological samples. T4 polynucleotide kinase is shown to efficiently phosphorylate strands of L-nucleic acids which allows the labeling with phosphorous isotopes such as (32)P. In order to protect the terminal phosphate label against unspecific phosphatases, one of two fragments of a Spiegelmer is enzymatically phosphorylated with [gamma-(32)P]ATP. In a second step we used a template- directed chemical ligation reaction in order to attach the labeled oligonucleotide to the other fragment to yield the full-length Spiegelmer with an internal [(32)P]phosphodiester bond. It has been shown that the functionality of a chemically ligated Spiegelmer is still retained.
Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption (2016)

Two-photon excited fluorescence (TPEF) imaging of the cellular cofactors nicotinamide adenine dinucleotide and oxidized flavin adenine dinucleotide is widely used to measure cellular metabolism, both in normal and pathological cells and tissues. When dual-wavelength excitation is used, ratiometric TPEF imaging of the intrinsic cofactor fluorescence provides a metabolic index of cells—the “optical redox ratio” (ORR). With increased interest in understanding and controlling cellular metabolism in cancer, there is a need to evaluate the performance of ORR in malignant cells. We compare TPEF metabolic imaging with seahorse flux analysis of cellular oxygen consumption in two different breast cancer cell lines (MCF-7 and MDA-MB-231). We monitor metabolic index in living cells under both normal culture conditions and, for MCF-7, in response to cell respiration inhibitors and uncouplers. We observe a significant correlation between the TPEF-derived ORR and the flux analyzer measurements (R=0.7901, p<0.001). Our results confirm that the ORR is a valid dynamic index of cell metabolism under a range of oxygen consumption conditions relevant for cancer imaging.
Updated Results of a Phase I Trial of Motexafin Lutetium-Mediated Interstitial Photodynamic Therapy in Patients with Locally Recurrent Prostate Cancer (2006)

Locally recurrent prostate cancer after treatment with radiation therapy is a clinical problem with few acceptable treatments. One potential treatment, photodynamic therapy (PDT), is a modality that uses laser light, drug photosensitizer, and oxygen to kill tumor cells through direct cellular cytotoxicity and/or through destruction of tumor vasculature. A Phase I trial of interstitial PDT with the photosensitizer Motexafin lutetium was initiated in men with locally recurrent prostate cancer. In this ongoing trial, the primary objective is to determine the maximally tolerated dose of Motexafin lutetium-mediated PDT. Other objectives include evaluation of Motexafin lutetium uptake from prostate tissue using a spectrofluorometric assay and evaluation of optical properties in the human prostate. Fifteen men with biopsy-proven locally recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled and 14 have been treated. Treatment plans were developed using transrectal ultrasound images. The PDT dose was escalated by increasing the Motexafin lutetium dose, increasing the 732 ran light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 24, 6, or 3 hr prior to 732 ran light delivery. The light dose, measured in real time with in situ spherical detectors was 25-100 J/cm2. Light was delivered via optical fibers inserted through a transperineal brachytherapy template in the operating room. Optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Fourteen patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I genitourinary symptoms that are PDT related have been observed. One patient had Grade II urinary urgency that was urinary catheter related. No rectal or other gastrointestinal PDT-related tox-icities have been observed to date. Measurements of Motexafin lutetium demonstrated the presence of photosensitizer in prostate tissue from all patients. Optical property measurements demonstrated substantial heterogeneity in the optical properties of the human prostate gland which supports the use of individualized treatment planning for prostate PDT.
An adaptive cooperation algorithm based on trade off between useful signal and interference alignment (2012)

In this paper, we design a cooperation algorithm for the constant MIMO interference channel that adapts the pre-coding and decorrelation matrices depending on system SNR. The algorithm sacrifices perfect interference alignment in some SNR regions when it becomes more beneficial to ameliorate the useful signal part instead of reaching perfect interference alignment. The proposed algorithm outperforms the minimum leakage interference alignment algorithm in terms of system sum-capacity at low and medium system SNR region. The convergence speed and fairness of the proposed algorithm are also studied.
Genetic Disorders of Surfactant Proteins (2007)

Inherited disorders of pulmonary surfactant-associated proteins are rare but provide important insights into unique mechanisms of surfactant dysfunction. Recessive loss-of-function mutations in the surfactant protein-B and the ATP-binding cassette family member A3 (ABCA3) genes present as lethal surfactant deficiency in the newborn, whereas other recessive mutations in ABCA3 and dominant mutations in the surfactant protein-C gene result in interstitial lung disease in older infants and children. The molecular basis and the genetic and tissue-based approaches to the evaluation of children suspected of having one of these disorders are discussed.
Comparison of Performance between R290 and R417A in Heat Pump Air Conditioning Water Heater Combination (2011)

The natural refrigerant R29O and mixed refrigerant R417A is currently approved ideal substitutes of R22, The performance of R290 and R410A in the same heat pump air conditioning water heater combination was studied experimentally, heating capacity, cooling capacity, power input, COP ,discharge pressure, suction pressure,discharge temperature were measured, the performance of heat pump air conditioning water heater combination at standard air condition and varied inlet-water temperature was analyzed .The results show that the most appropriate charge mass of R290 is only 52% of R417A in the same systems ,so using r290 more environmentally friendly.The coefficient of performance (COP) is higher than R417A in the same capacity, so using r290 have lower energy consumption, more energy-saving. Compressor discharge pressure and temperatures of R290 is lower than R417A in the same inlet-water temperature, so using r290 favors the system security operation. But the performance of R290 influenced by the inlet water temperature more obvious than R417A, it's not very suitable for the occasion of high inlet-water temperature.
CD8+T Cell Depletion Amplifies Hepatitis C Virus Replication in Peripheral Blood Mononuclear Cells (2005)

We investigated the ability of CD8+ T cells to inhibit hepatitis C virus (HCV) replication in peripheral blood mononuclear cells (PBMCs). PBMCs isolated from 11 of 20 HCV-infected subjects had no detectable HCV RNA. Removal of CD8+ T cells from these PBMCs resulted in detection of HCV RNA, and depletion of CD8+ T cells from PBMCs that had detectable HCV RNA amplified HCV replication. Reconstitution of CD8- PBMCs with autologous CD8+ T cells led to inhibition of HCV replication. Interferon-gamma produced by CD8+ T cells was partially responsible for CD8+ T cell-mediated noncytotoxic anti-HCV activity in PBMCs. This noncytotoxic anti-HCV activity was confirmed in HCV replicon cells. Supernatants from CD8+ T cell cultures inhibited HCV RNA expression in the replicon cells. These findings may have important implications for the immunopathogenesis of HCV in both immune and hepatic cells and are relevant to the development of host innate immunity-based anti-HCV interventions.
G-CSF activates STAT pathways in Kasumi-1 myeloid leukemic cells with the t(8; 21) translocation: basis for potential therapeutic efficacy. (1997)

In an attempt to find new agents that promote differentiation and have therapeutic potential in acute myeloid leukemias, we have studied the effect of recombinant human granulocyte colony stimulating factor (rhG-CSF) on the Kasumi-1 AML2 t(8; 21) cell line. Upon incubation with rhG-CSF (0.2-2000 ng/ml), Kasumi-1 cells showed a peak of cell growth, with a subsequent decrease of cell survival after 4 days of culture. At that time, more than 80% of the cell population expressed myeloid differentiation antigens (CD11b, CD13, CD15 and CDw85), and increased G-CSF receptors. Gel shift assays were performed with nuclear extracts of Kasumi-1 cells after 1, 5, 10, 15, 30 and 60 min incubations with G-CSF and oligonucleotides containing the high-affinity SIF-binding site. At least three specific complexes were obtained, and shown by supershift assays to be STAT3/STAT3, STAT1/STAT3 and STAT1/STAT1 dimers. These results suggest that in G-CSF-sensitive Kasumi-1 cells, normal JAK-STAT pathways are activated, providing a further molecular basis for the effect of G-CSF in these cells.
Identification of the Region Required for Monomerization of the Rolling Circle Plasmid pKYM (1998)

Plasmid pKYM, isolated from the gram-negative bacterium Shigella sonnei, is a small multicopy plasmid which replicates by a rolling circle mechanism. The formation of multimers has been observed in a derivative of pKYM which lost a part of the origin region, and the loss of the monomerization mechanism would have led to these multimers. By analyzing the constructs of several mutants, we discovered that a DNA region required for monomerization was present upstream of the RepK binding site in the replication origin. As either of the T-rich sequence or the inverted repeat sequences which were seen in that region have been lost in the multimer-forming plasmids, these sequences may be necessary for monomerization.
Line drawings via abstracted shading (2007)

We describe a GPU-based algorithm for rendering a 3D model as a line drawing, based on the insight that a line drawing can be understood as an abstraction of a shaded image. We thus render lines along tone boundaries or thin dark areas in the shaded image. We extend this notion to the dual: we render highlight lines along thin bright areas and tone boundaries. We combine the lines with toon shading to capture broad regions of tone.
Scanning electron microscopic study of modern silicone intraocular lenses (1992)

Silicone, as manufactured today, appears to be a biocompatible material. The safety and efficacy of silicone lenses are primarily related to the intraocular lens (IOL) design. We compared the edge finish of two three-piece polypropylene loop foldable silicone IOL designs (Allergan Medical Optics) and three one-piece designs (Staar Surgical Co., CooperVision-Cilco). Except for an early Staar one-piece design, all lenses including the more recent Staar lenses had acceptably smooth edges with minimal molding flash.
Differential survival of solitary and aggregated bacterial cells promotes aggregate formation on leaf surfaces (2003)

The survival of individual Pseudomonas syringae cells was determined on bean leaf surfaces maintained under humid conditions or periodically exposed to desiccation stress. Cells of P. syringae strain B728a harboring a GFP marker gene were visualized by epifluorescence microscopy, either directly in situ or after recovery from leaves, and dead cells were identified as those that were stained with propidium iodide in such populations. Under moist, conducive conditions on plants, the proportion of total live cells was always high, irrespective of their aggregated state. In contrast, the proportion of the total cells that remained alive on leaves that were periodically exposed to desiccation stress decreased through time and was only approximately 15% after 5 days. However, the fraction of cells in large aggregates that were alive on such plants in both condition was much higher than more solitary cells. Immediately after inoculation, cells were randomly distributed over the leaf surface and no aggregates were observed. However, a very aggregated pattern of colonization was apparent within 7 days, and >90% of the living cells were located in aggregates of 100 cells or more. Our results strongly suggest that, although conducive conditions favor aggregate formation, such cells are much more capable of tolerating environmental stresses, and the preferential survival of cells in aggregates promotes a highly clustered spatial distribution of bacteria on leaf surfaces.
Closed Contour Specular Reflection Segmentation in Laparoscopic Images (2013)

Segmentation of specular reflections is an essential step in endoscopic image analysis; it affects all further processing steps including segmentation, classification, and registration tasks. The dichromatic reflectance model, which is often used for specular reflection modeling, is made for dielectric materials and not for human tissue. Hence, most recent segmentation approaches rely on thresholding techniques. In this work, we first demonstrate the limited accuracy that can be achieved by thresholding techniques and propose a hybrid method which is based on closed contours and thresholding. The method has been evaluated on 269 specular reflections in 49 images which were taken from 27 real laparoscopic interventions. Our method improves the average sensitivity by 16% compared to the state-of-the-art thresholding methods.
Data-driven route guidance under the framework of model predictive control (2010)

Real-time traffic assignment for route guidance is put under the framework of model predictive control, which optimizes the routes based on the real-time feedback and prediction information of road network. In this framework, particle filter is utilized to estimate the statistic distribution of traffic flow of links without detection sensors based on the position and speed information of navigated vehicles on those links and the prior information of traffic flow of links with detection sensors. The chance constrains and Bayes-based route prediction are incorporated into the optimization model so that the stochastic characteristics of traffic needs, propagation and driver's decision-making behavior can be compensated in the route optimization. To check the chance constraints, the min-max characteristic points are used to fit the curve of stochastic traffic propagation process with stochastic needs to avoid the exponential increase of combination calculation. The genetic algorithm is utilized for the optimization with feasible-direction-search crossover and mutation to improve the evolution efficiency, combined with the traffic simulation in the mean sense with the compensation of stochastic parts of traffic flow data to evaluate the performance of real-time traffic assignment. The simulation results demonstrate the effectiveness of traffic navigation predictive control.
Efficient RF-PA Two-Chip Supply Modulator Architecture for 4G LTE and 5G NR Dual-Connectivity RF Front End (2022)

This article presents a two-chip supply modulation architecture for efficient RF power amplification using a fully switched-mode supply modulator (SM) and a linear-assisted hybrid SM to support simultaneous transmission on long-term evolution (LTE) and 5G bands. The designed fully switched-mode SM consists of a fast switching buck converter and a slow switching buck converter, and it achieves 88.2% peak efficiency and a low receiver (RX) band noise of −140 dBm/Hz at the SM output. The fully switched-mode SM tracks the envelope of LTE 5-/10-/20-MHz signals with the average switching frequencies of 50/70/120 MHz, respectively. The ET-PA measured using the fully switched-mode SM and LTE band-3 power amplifier module integrated duplexer (PAMiD) saves the dc power consumption of 320 mW at a 23-dBm output power compared to an average power tracking (APT)-PA. The designed 5G new radio (NR) SM consisting of a class-AB linear amplifier (LA) and an interleaved three-level buck–boost converter provides a 160-MHz 3-dB bandwidth to track the envelope of a 100-MHz NR signal. The measured peak SM efficiency is 84.1% at a 3.53-W output power. The measured ET-PA with 5G NR SM and 5G n77 PAMiD achieves an ACLR of −36.9 dBc at a 27.45-dBm output power with a 6-dB peak-to-average-power ratio DFT-spread-OFDM NR 100-MHz quadrature phase shift keying (QPSK) signal. It saves the dc power consumption of 950 mW at a 27-dBm output power compared to APT-PA. An optimal RF power amplifier (RF-PA) supply deployment using the two SMs efficiently supports multiple RF-PA loads while satisfying the dual-transmission requirements of E-UTRAN new radio dual-connectivity (EN-DC) and 5G 100-MHz ET operation. The fully switched-mode SM is implemented in a 130-nm CMOS process, and the die size is 4.0 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The 5G NR SM is implemented in a 90-nm CMOS process, and the die size is 6.75 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .