gebhart/patrepeval huggingface dataset:
GPS-Net: Graph Property Sensing Network for Scene Graph Generation (2020)

Scene graph generation (SGG) aims to detect objects in an image along with their pairwise relationships. There are three key properties of scene graph that have been underexplored in recent works: namely, the edge direction information, the difference in priority between nodes, and the long-tailed distribution of relationships. Accordingly, in this paper, we propose a Graph Property Sensing Network (GPS-Net) that fully explores these three properties for SGG. First, we propose a novel message passing module that augments the node feature with node-specific contextual information and encodes the edge direction information via a tri-linear model. Second, we introduce a node priority sensitive loss to reflect the difference in priority between nodes during training. This is achieved by designing a mapping function that adjusts the focusing parameter in the focal loss. Third, since the frequency of relationships is affected by the long-tailed distribution problem, we mitigate this issue by first softening the distribution and then enabling it to be adjusted for each subject-object pair according to their visual appearance. Systematic experiments demonstrate the effectiveness of the proposed techniques. Moreover, GPS-Net achieves state-of-the-art performance on three popular databases: VG, OI, and VRD by significant gains under various settings and metrics. The code and models are available at \url{https://github.com/taksau/GPS-Net}.
Nanoporous tin(IV) sulfides: Mode of formation (1994)

Nanoporous R‐SnS‐ n materials e.g. (Et 4 N) 2 Sn 3 S 7 , have been sythesized and characterized. The crystal structures of two molecular tin(IV) sulfide species that are thought to be important in the formation of these materials are reported. Both contain the dimer (Sn 2 S 6 ) 4⊖ , which can be combined (see Fingure) to form the Sn 4 S 4 broken‐cube clusters that constitute the open framework of R‐SnS‐1. magnified image
Holographic interference filters for infrared communications (2003)

We demonstrate that high-quality interference filters for the wavelength range 1300-1600 nm can be holographically fabricated in DuPont HRF-800X001 photopolymer material by use of visible laser illumination. We also summarize a chain-matrix technique, which we call thin-film decomposition, that is useful for modeling multilayer films with an arbitrary index profile n(z). We use the thin-film-decomposition technique to create design curves that allow one to choose the proper exposure angle and film thickness with which to fabricate a holographic interference filter with a desired transmission efficiency and bandwidth at a particular wavelength. These curves are of general utility and are not confined to any particular holographic recording medium. Excellent agreement between theory and experiment is found.
Heck and Other C—C Coupling Reactions (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of Novel Organotin-Phosphorous Compounds II (2010)

New organotin substituted alpha-anilinomethylphosphonates were prepared and were characterized by FT-IR, 1H- and 13C-NMR spectroscopy and elemental microanalysis.
Data Tainting and Obfuscation: Improving Plausibility of Incorrect Taint (2015)

International audience
A Labor Measurement Structure for Retail Operations (2006)

To compete effectively with the competition, retail companies like Karls need to adopt work measurement techniques to understand and plan for the correct amount of payroll. Proper allocation of payroll equates to a better sales margin and healthy bottom line. In order to improve the current work measurement process implemented at Karls, the following describes an industry and academic process to improve the quality and efficiency of their Engineered Labor Standards. Included is a summation of what other companies are doing with ELS, what tools and techniques are available to develop them, and an evaluation of each as they can be used at Karls. The result is a time study structure that gives statistical quality analysis, improved data collection methods, and formalized reports. The structure also includes new tools and software to use, which will speed up the rate at which standards are developed as well as make them more accurate. These tools include personal digital assistants and the time study software, Workstudy+. The structure also describes how to use the StandardsPro software to create standards for hypothetical jobs as well as a database of job elements to reference for re-evaluations of old processes. The final product is a new work measurement program with improved accuracy and data collection efficiency versus Karls current program. This program will allow engineers to produce more accurate standards quickly. The improved measurements will also allow managers to make better decisions. The program also supports process improvements, company benchmarking and an ability to create detailed cost benefit analysis. This program will be the base for the future of the store operations engineering department.
Phase I combination study of trabectedin (T) and capecitabine (C) in patients with advanced malignancies (2006)

2079 Background: T binds to the minor groove of DNA, synergizes with functional nuclease excision repair and targets inducible transcription. T is active in several tumor types and exhibits preclinical synergy with C. The primary objective of this study is to determine the maximum tolerated dose (MTD) of T in combination with C. Secondary objectives include safety and pharmacokinetic (PK) analyses. Methods: Pts with advanced cancer, performance status 0–1 and adequate organ function are eligible. Pts received T starting at 0.4 mg/m 2 over 3 hours on day 1 followed by C on days 2 through 15. The initial dose of C was 2000 mg/m 2 /day and was reduced to 1600 mg/m 2 /day due to GI dose-limiting toxicity. Dose escalation of T continued. Cycles are repeated every 3 weeks, with PK sampling included. Standard “3+3” dose escalation design, definitions of dose limiting toxicity (DLT), and dose modification for toxicity are implemented. Results: To date, 30 patients have received 112 cycles (range 1–12, median 4) of treatment at 7 dose levels. Two of 3 pts at dose level 4 (C 2000 mg/m 2 /d and T 0.9 mg/m 2 ) and 2/6 pts at dose level 3 (C 2000 mg/m 2 /d and T 0.75 mg/ m 2 ) developed gastrointestinal DLT (emesis, diarrhea, pancreatitis). C was subsequently reduced to 1600 mg/m 2 /d and a new T dose escalation was initiated at 0.6 mg/m 2 . Treatment has been well tolerated with C 1600 mg/m 2 /d and T up to the current dose of 0.9 mg/m 2 (dose level 4a), with 1of 6 subjects experiencing grade 1 alkaline phosphatase. The most frequently reported related grade 3–4 adverse events (AEs) are diarrhea (23%), neutropenia (20%), nausea (16.6%), hand-foot syndrome (16.6%) and vomiting (13%). Anti-tumor activity to date includes a confirmed partial response lasting 8 months (m) in a patient with cholangiocarcinoma, and prolonged stable disease in 2 patients with breast cancer (6 and 7m), ovarian cancer (11m) and chondrosarcoma (9m). Conclusions: The combination of C 1600mg/m 2 /d and T up to 0.9mg/m 2 is tolerable and has promising activity in several tumor types. Dose escalation of T continues at 1.1 mg/m 2 . Biologic and pharmacokinetic analyses will be presented. [Table: see text]
Molecular Cloning of the cDNA of Heat Shock Protein 88 Gene from the Entomopathogenic Fungus, Paecilomyces tenuipes Jocheon-1 (2014)

The full-length heat shock protein 88 (HSP88) complementary DNA (cDNA) of Paecilomyces tenuipes Jocheon-1 was obtained by screening the Paecilomyces tenuipes (P. tenuipes) Jocheon-1 Uni-Zap cDNA library and performing 5' RACE polymerase chain reaction (PCR). The P. tenuipes Jocheon-1 HSP88 cDNA contained an open reading frame (ORF) of 2,139-basepair encoding 713 amino acid residues. The deduced amino acid sequence of the P. tenuipe s Jocheon-1 HSP88 cDNA showed 77% identity to Nectria haematococca HSP88 and 45-76% identity to other fungal homologous HSP88s. Phylogenetic analysis and BLAST program analysis confirmed that the deduced amino acid sequences of the P. tenuipes Jocheon-1 HSP88 gene belonged to the ascomycetes group within the fungal clade. The P. tenuipes Jocheon-1 HSP88 also contained the conserved ATPase domain at the N-terminal region. The cDNA encoding P. tenuipes Jocheon-1 HSP88 was expressed as an 88 kilodalton (kDa) polypeptide in baculovirus-infected insect Sf9 cells. Under higher temperature conditions for the growth of the entomopathogenic fungus, mRNA expression of P. tenuipes Jocheon-1 HSP88 was quantified by real time PCR (qPCR). The results showed that heat shock stress induced a higher level of mRNA expression compared to normal growth conditions.
Colloidal stability of nanoparticles derived from simulated cloud-processed mineral dusts (2013)

Laboratory simulation of cloud processing of three model dust types with distinct Fe-content (Moroccan dust, Libyan dust and Etna ash) and reference goethite and ferrihydrite were conducted in order to gain a better understanding of natural nanomaterial inputs and their environmental fate and bioavailability. The resulting nanoparticles (NPs) were characterised for Fe dissolution kinetics, aggregation/size distribution, micromorphology and colloidal stability of particle suspensions using a multi-method approach. We demonstrated that the: (i) acid-leachable Fe concentration was highest in volcanic ash (1 m Mg(-1) dust) and was followed by Libyan and Moroccan dust with an order of magnitude lower levels; (ii) acid leached Fe concentration in the<20 nm fraction was similar in samples processed in the dark with those under artificial sunlight, but average hydrodynamic diameter of NPs after cloud-processing (pH~6) was larger in the former; iii) NPs formed at pH~6 were smaller and less poly-disperse than those at low pH, whilst unaltered zeta potentials indicated colloidal instability; iv) relative Fe percentage in the finer particles derived from cloud processing does not reflect Fe content of unprocessed dusts (e.g. volcanic ash>Libyan dust). The common occurrence of Fe-rich "natural nanoparticles" in atmospheric dust derived materials may indicate their more ubiquitous presence in the marine environment than previously thought.
s-Indacene Revisited: Modular Synthesis and Modulation of Structures and Molecular Orbitals of Hexaaryl Derivatives (2023)

Though <i>s</i>-indacene is an intriguing antiaromatic hydrocarbon of 12 π-electrons, it has been underrepresented due to the lack of efficient and versatile methods to prepare stable derivatives. Herein we report a concise and modular synthetic method for hexaaryl-<i>s</i>-indacene derivatives bearing electron-donating/-accepting groups at specific positions to furnish <i>C</i><sub>2<i>h</i></sub>-, <i>D</i><sub>2<i>h</i></sub>-, and <i>C</i><sub>2<i>v</i></sub>-symmetric substitution patterns. We also report the effects of substituents on their molecular structures, frontier molecular orbital (MO) levels, and magnetically induced ring current tropicities. Both theoretical calculations and X-ray structure analyses indicate that the derivatives of the <i>C</i><sub>2<i>h</i></sub>-substitution pattern adopt different <i>C</i><sub>2<i>h</i></sub> structures with significant bond length alternation depending on the electronic property of the substituents. Due to the nonuniform distribution of the frontier MOs, their energy levels are selectively modulated by the electron-donating substituents. This leads to the inversion of the HOMO and HOMO-1 sequences with respect to those of the intrinsic <i>s</i>-indacene as theoretically predicted and experimentally proven by the absorption spectra at visible and near-infrared regions. The NICS values and the <sup>1</sup>H NMR chemical shifts of the <i>s</i>-indacene derivatives indicate their weak antiaromaticity. The different tropicities are explained by the modulation of the HOMO and HOMO-1 levels. In addition, for the hexaxylyl derivative, weak fluorescence from the S<sub>2</sub> excited state was detected due to the large energy gap between the S<sub>1</sub> and S<sub>2</sub> states. Notably, an organic field-effect transistor (OFET) fabricated using the hexaxylyl derivative exhibited moderate hole carrier mobility, a result which opens the door for optoelectronic applications of <i>s</i>-indacene derivatives.
ChemInform Abstract: Unsaturated Epoxy‐C‐Glycosides. A New Class of Antitumor Compounds with DNA Cleavage Properties. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of the Substitution of Ni by N and Mn in Lean Duplex Stainless Steels on Stress Corrosion Cracking Assisted by H2S (2017)

Abstract The importance of passive film stability and mechanical properties of the UNS(1) S32304, S32202 and S32101 Lean Duplex Stainless Steel grades on Stress Corrosion Cracking (SCC) is discussed in this paper. Measurement of uniform corrosion resistance in the presence of H2S, through polarization curves, and slip steps height and spacing, through Atomic Force Microscopy technique (AFM) have been performed. Results show that, as opposed to N, Mn decreases the passive film stability and slip steps height and spacing at the surface of the austenitic phase. Therefore, on the basis of slow strain rate tensile tests where the grade S32202 show a greater SCC resistance than the grades S32304 and S32101, it can be concluded that the electrochemical passive film stability makes the larger contribution to SCC phenomenon and so the negative impact of Mn.
Role of cytokines in inflammatory bowel disease (2008)

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), represents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. Mucosal macrophages play an important role in the mucosal immune system, and an increase in the number of newly recruited monocytes and activated macrophages has been noted in the inflamed gut of patients with IBD. Activated macrophages are thought to be major contributors to the production of inflammatory cytokines in the gut, and imbalance of cytokines is contributing to the pathogenesis of IBD. The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Cytokines play a key role in IBD that determine T cell differentiation of Th1, Th2, T regulatory and newly described Th17 cells. Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cytokine therapies have been developed and tested for the treatment of IBD patients.
A Ku-band 6-bit digital phase shifter MMIC for phased array antenna systems (2015)

This paper presents a 6-bit digital phase shifter designed at Ku-band for electronic beam steering of satellite based phased array antenna systems. The phase shifter is implemented using space qualified 0.25-μm pHEMT GaAs MMIC process. Each individual bit of the phase shifter is designed using optimum topology to achieve minimal insertion loss, accurate phase shifting and low amplitude variations. The measured performance of all 64 states of the phase shifter demonstrates an insertion loss of 6.1±0.6 dB with RMS phase error < 1.3°, RMS amplitude error < 0.35 dB and return losses better than 15 dB over 12–13 GHz frequency range. The circuit consumes negligible power (<0.5mW) and has dimensions of 6.1×1.5 mm2 to fit in a multi-function single chip beam forming MMIC. The low insertion loss and high accuracy of the phase shifter are key features of the MMIC, making it suitable for high precision beam forming applications.
Angiotensin dependence of endothelium-mediated renal hemodynamics. (1992)

Endothelium-derived relaxing factor has been shown to regulate renal blood flow, and inhibition of its synthesis increases blood pressure and renal vascular resistance and decreases renal blood flow. Using the substrate antagonist NW-nitro-L-arginine methyl ester (L-NAME), we tested whether renal vasoconstriction induced by endothelium-derived relaxing factor synthesis inhibition could be mediated in part by angiotensin II. In 14 control rats, 10 mg/kg body wt L-NAME increased blood pressure from 106 +/- 6 to 126 +/- 6 mm Hg (p < 0.001), increased renal vascular resistance by 74% (from 19.3 +/- 2.6 to 33.6 +/- 2.9 resistance units), and decreased renal blood flow by 34% (from 5.9 +/- 0.5 to 3.9 +/- 0.3 ml.min-1.g kidney wt-1, p < 0.005). When six rats were treated with 10 mg/kg body wt of the angiotensin receptor antagonist DuP 753, L-NAME increased blood pressure from 84 +/- 4 to 106 +/- 4 mm Hg (p < 0.001); however, renal vascular resistance increased by only 27% (from 13 +/- 2 to 17 +/- 3 resistance units, p < 0.01; p < 0.05 different from control value) and renal blood flow was unchanged. Likewise, after pretreatment of six rats with 32 micrograms/100 g body wt of the angiotensin converting enzyme inhibitor enalaprilat, L-NAME increased blood pressure from 88 +/- 5 to 124 +/- 6 mm Hg (p < 0.001) and renal vascular resistance by 54% (from 12 +/- 1 to 18 +/- 3 resistance units, p < 0.01; p < 0.05 different from control value) but renal blood flow was unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
Design of large embedded CMOS PLAs for built-in self-test (1988)

A novel scheme to design built-in self-test programmable logic arrays (PLAs) implemented with CMOS technology is described, which is attractive for large arrays. These PLAs can perform function-independent self-test at normal operating speed, can detect CMOS switch-level faults, and have a lower area overhead than any other BIST scheme. A sequential parity checking technique is used to test for the AND and OR arrays of the PLA. This technique does not require any XOR cascade to evaluate parity data as in the parallel checking technique used by other schemes, thus achieving an order of magnitude reduction in total testing time. The method accounts for switch-level stuck-open and stuck-on faults in addition to conventional stuck-at, crosspoint, and bridging faults. A novel circuit design technique was used to implement the test pattern generator for product lines. It makes use of a Johnson counter and a two-level decoding network to obtain a very low area overhead and to match the pitch between the PLA and the test circuitry.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A combined approach for high-performance Li–O2 batteries: A binder-free carbon electrode and atomic layer deposition of RuO2 as an inhibitor–promoter (2017)

A rechargeable lithium–oxygen (Li–O2) battery is considered as a promising technology for electrochemical energy storage systems because its theoretical energy density is much higher than those of state-of-the-art Li-ion batteries. The cathode (positive electrode) for Li–O2 batteries is made of carbon and polymeric binders; however, these constituents undergo parasitic decomposition reactions during battery operation, which in turn causes considerable performance degradation. Therefore, the rational design of the cathode is necessary for building robust and high-performance Li–O2 batteries. Here, a binder-free carbon nanotube (CNT) electrode surface-modified by atomic layer deposition (ALD) of dual acting RuO2 as an inhibitor–promoter is proposed for rechargeable Li–O2 batteries. RuO2 nanoparticles formed directly on the binder-free CNT electrode by ALD play a dual role to inhibit carbon decomposition and to promote Li2O2 decomposition. The binder-free RuO2/CNT cathode with the unique architecture shows outstanding electrochemical performance as characterized by small voltage gaps (∼0.9 V) as well as excellent cyclability without any signs of capacity decay over 80 cycles.
Kinetic Separation of Amperometric Responses of Composite Redox-Active Monolayers Assembled onto Au Electrodes:  Implications to the Monolayers' Structure and Composition (1997)

Chronoamperometry provides a sensitive method to elucidate the composition and properties of complex redox-active monolayers assembled onto Au electrodes. Chronoamperometry is applied to characterize a redox-active monolayer composed of a bisdiaminobenzoquinone dyad. The different distances of the quinone units in respect to the electrode yield different electron-transfer rate constants, k1 = 25.3 s-1 and k2 = 1.05 s-1, and the surface coverage of the two quinone units is estimated to be ΓQ1 = 6.5 × 10-11 mol cm-2 and ΓQ2 = 6.5 × 10-11 mol cm-2. The surface densities of the quinone units coincide nicely with those obtained by voltammetric analysis of the monolayer during the steps of its assembly. Similarly, a binary monolayer consisting of bipyridinium and anthraquinone redox-active units was characterized by chronoamperometry. The electron-transfer rate constant to the bipyridinium and anthraquinone components corresponds to k1 = 503 s-1 and k2 = 62 s-1, respectively, and the surface coverage of the redox-active groups is ΓV2+ = 1.44 × 10-10 mol cm-2 and ΓQ = 0.46 × 10-10 mol cm-2. Kinetic separation of the amperometric response of a redox-active monolayer formed by the coupling of N,N‘-bis(7-carboxyheptyl)-4,4‘-bipyridinium, V2+−(CO2H)2, to a cystamine-modified monolayer on an Au electrode, reveals the formation of two redox-active groups within the monolayer assembly: one redox-active form consists of a single-point attachment of V2+−(CO2H)2 to the electrode, whereas the second form includes the bifunctional, two-point linkage of V2+-(CO2H)2 to the monolayer. The surface coverage of the two redox-active forms corresponds to Γ1 = 1.11 × 10-10 and Γ2 = 1.13 × 10-10 mol cm-2, respectively. The electron-transfer rate constants to the single-point-associated bipyridinium sites and to the two-point linkage bipyridinium units are k1 = 508 s-1 and k2 = 896 s-1, respectively. Chronoamperometric analysis of microperoxidase-11 assembled as a monolayer on an Au electrode reveals that the heme-substituted oligopeptide binds to the surface by two different modes. These include the covalent linkage of carboxylic functions associated with the porphyrin ligand or the peptide backbone to the primary cystamine monolayer assembled onto the Au electrode.
Development of Mucoadhesive Drug Delivery System Using Phenylboronic Acid Functionalized Poly(D,L‐lactide)‐b‐Dextran Nanoparticles (2012)

Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that NPs encapsulated up to 13.7 wt% CycA and exhibited sustained release for up to 5 d in vitro at a clinically relevant dose. We fine-tuned the PBA density on the NP surface to maximize the mucin-NP interaction without compromising the particle stability in vitro. This block copolymer conjugate may be useful to improve the bioavailability of topical formulations.
La modélisation d'antennes imprimées : quelques problématiques choisies (2008)

National audience
ChemInform Abstract: Synthesis of (.+‐.)‐Tylophorine by the Intramolecular Cycloaddition of an Azide with an ω‐Chloroalkene. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.