gebhart/patrepeval huggingface dataset:
Varieties in finite transformation groups (1988)

The equivariant cohomology ring of a G-space X defines a homogeneous affine variety. Quillen [Q] and W. Y. Hsiang [Hs] have determined the relation between such varieties and the family of isotropy subgroups as well as their fixed point sets when dim X < oo. In modular representation theory, J. Carlson [Cj] introduced cohomological support varieties and rank varieties (the latter depending on the group algebra) and explored their relationship. We define rank and support varieties for G-spaces and G-chain complexes and apply them to cohomological problems in transformation groups. As a corollary, a useful criterion for ZG-projectivity of the reduced total homology of certain G-spaces is obtained, which improves the projectivity criteria of Rim [R], Chouinard [Ch], and Dade [D].
Effects of Interstitial Irradiation alone, or in Combination with Localized Hyperthermia on the Response of a Mouse Mammary Tumor (1978)

Assessment has been made on the effects of interstitial irradiation from 226Ra and localized hyperthermia, either alone or in combination, on the growth of a transplantable mammary sarcoma (EMT6) in the mouse. Tumor responses to the combined treatments indicated a maked interaction of these two agents. Localized hyperthermia (43°Celsius, 1 hr) combined with interstitial irradiation led to greater than a 60 percent reduction in tumor volume after 4 days of continuous treatment, compared to only a 20 percent reduction in tumor volume when either agent was given alone. These data suggest that such combined treatment may be of benefit in certain localized human cancers in which interstitial radiation treatment is in current use.
Fluorine Substitution Induced High Tc of Enantiomeric Perovskite Ferroelectrics: (R)- and (S)-3-(Fluoropyrrolidinium)MnCl3 (2019)

The past decade has witnessed much progress in designing molecular ferroelectrics, whose intrinsic mechanical flexibility, structural tunability, and easy processability are desirable for next-generation flexible and wearable electronic devices. However, an obstacle in expanding their promising applications in nonvolatile memory elements, capacitors, and sensors is effectively modulating the Curie temperature ( T<sub>c</sub>). Here, taking advantage of fluorine substitution on the reported molecular ferroelectric, (pyrrolidinium)MnCl<sub>3</sub>, we present enantiomeric perovskite ferroelectrics, namely, ( R) - and ( S) -3-(fluoropyrrolidinium)MnCl<sub>3</sub>. The close van der Waal's radii and the similar steric parameters between H and F atoms ensure the minimum disruption of the crystal structure, while their different electronegativity and polarizability can trigger significant changes in the physical and chemical properties. As expected, the T<sub>c</sub> gets successfully increased from 295 K in (pyrrolidinium)MnCl<sub>3</sub> to 333 K in these two homochiral compounds. Such a dramatic enhancement of 38 K signifies an important step toward designing high- T<sub>c</sub> molecular ferroelectrics. In the light of the conceptually new idea of fluorine substitution, one could look forward to a continuous succession of new molecular ferroelectric materials and technology developments.
Long‐term tracheal intubation practice in the United Kingdom (1983)

A questionnaire was circulated to members of the Intensive Care Society and hospitals with more than 120 acute beds in the United Kingdom. The object was to determine the usage of the various types of cuffs on tracheal tubes and the practice of long-term tracheal intubation in contrast to tracheostomy. One hundred and fifty two replies were received (a 55% response rate). The majority of units favoured the high volume cuff for long term ventilation (61% for tracheal tubes and 69.2% for tracheostomy tubes). The cuffs were mainly inflated to 'no-leak' ventilation and pressure was not measured. The majority of units changed from tracheal tubes to tracheostomy after about one week but, for children, a longer period of tracheal intubation is employed. The results are discussed.
Differential Repair of Radiation-Induced DNA Damage in Cells of Human Squamous Cell Carcinoma and the Effect of Caffeine and Cysteamine on Induction and Repair of DNA Double-Strand Breaks (1994)

The goal of these experiments was to investigate further the relationship between DNA double-strand breaks and cell killing in human tumor cells, first by comparing different cell lines, and second by radiomodification studies. Field-inversion gel electrophoresis was used to quantify double-strand breaks. Two subclones of the radioresistant human squamous cell carcinoma line SQ20B (SQD9 and SQG6) were compared. These subclones differed in DNA index by a factor of 1.7 but showed the same resistance to radiation as cells of the parental cell line. It was found that, although induction of DSBs was not significantly different in the two cell lines, the t1/2 of the fast component of repair was significantly shorter for SQD9 cells, leading to greater overall repair which was not reflected in increased survival. Caffeine and cysteamine were tested as modifiers of radiosensitivity, using the radioresistant SQ20B line and the radiosensitive SCC61 cell line. No effect of caffeine was seen when the drug was present only during irradiation. Postirradiation incubations with caffeine, however, resulted in a dose reduction factor greater than 2.0 in cell survival for both cell lines. In contrast, induction of DSBs was reduced by caffeine, and no effect on DSB repair was observed. Cysteamine led to a dose protection factor greater than 1.8 in cell survival in both cell lines. A reduction in induced DSBs was found at high doses corresponding approximately with the increase in cell survival. Over the same (low) dose range, however, the correlation between DSB induction and cell killing was poor. These data indicate that DSB induction does not correlate well with cell killing either for different cell lines, for radiochemical modification (cysteamine) or for some other types of modification (caffeine).
On Maxwell's displacement current for energy and sensors: the origin of nanogenerators (2017)

Self-powered system is a system that can sustainably operate without an external power supply for sensing, detection, data processing and data transmission. Nanogenerators were first developed for self-powered systems based on piezoelectric effect and triboelectrification effect for converting tiny mechanical energy into electricity, which have applications in internet of things, environmental/infrastructural monitoring, medical science and security. In this paper, we present the fundamental theory of the nanogenerators starting from the Maxwell equations. In the Maxwell's displacement current, the first term ε0∂E∂t gives the birth of electromagnetic wave, which is the foundation of wireless communication, radar and later the information technology. Our study indicates that the second term ∂P∂t in the Maxwell's displacement current is directly related to the output electric current of the nanogenerator, meaning that our nanogenerators are the applications of Maxwell's displacement current in energy and sensors. By contrast, electromagnetic generators are built based on Lorentz force driven flow of free electrons in a conductor. This study presents the similarity and differences between pieozoelectric nanogenerator and triboelectric nanogenerator, as well as the classical electromagnetic generator, so that the impact and uniqueness of the nanogenerators can be clearly understood. We also present the three major applications of nanogenerators as micro/nano-power source, self-powered sensors and blue energy.
Amycolatopsis methanolica sp. nov., a Facultatively Methylotrophic Actinomycete (1990)

The generic position of a gram-positive, facultatively methylotrophic actinomycete known as Nocardia sp. strain 239 was determined by comparing reverse transcriptase sequences of 16S rRNA. The assignment of the organism to the genus Amycolatopsis was strongly supported by chemotaxonomic and morphological data. A comparison with the type strains of validly described Amycolatopsis species showed that the organism formed the nucleus of a new species. The name proposed for this new species is Amycolatopsis methanolica. The organism has been deposited in the National Collection of Industrial Bacteria as NCIB 11946.
Fully Automated Electro Membrane Extraction Autosampler for LC–MS Systems Allowing Soft Extractions for High-Throughput Applications (2016)

The current work describes the implementation of electro membrane extraction (EME) into an autosampler for high-throughput analysis of samples by EME-LC-MS. The extraction probe was built into a luer lock adapter connected to a HTC PAL autosampler syringe. As the autosampler drew sample solution, analytes were extracted into the lumen of the extraction probe and transferred to a LC-MS system for further analysis. Various parameters affecting extraction efficacy were investigated including syringe fill strokes, syringe pull up volume, pull up delay and volume in the sample vial. The system was optimized for soft extraction of analytes and high sample throughput. Further, it was demonstrated that by flushing the EME-syringe with acidic wash buffer and reverting the applied electric potential, carry-over between samples can be reduced to below 1%. Performance of the system was characterized (RSD, <10%; R(2), 0.994) and finally, the EME-autosampler was used to analyze in vitro conversion of methadone into its main metabolite by rat liver microsomes and for demonstrating the potential of known CYP3A4 inhibitors to prevent metabolism of methadone. By making use of the high extraction speed of EME, a complete analytical workflow of purification, separation, and analysis of sample could be achieved within only 5.5 min. With the developed system large sequences of samples could be analyzed in a completely automated manner. This high degree of automation makes the developed EME-autosampler a powerful tool for a wide range of applications where high-throughput extractions are required before sample analysis.
Gram‐Positive Bacteria as Biocatalysts to Convert Biomass Derived Sugars into Biofuel and Chemicals (2008)

This chapter contains sections titled: Introduction Biomass hydrolysates Fermentation processes Ethanologens Lactate production by gram-positive microbes Conclusions References
Critical Comments on Magnetoencephalographic Studies of Epileptic Patients (1990)

Click to increase image sizeClick to decrease image sizeKey Words: magnetoencephalographyepilepsysource localization
Learning to Localize Sound Sources in Visual Scenes: Analysis and Applications (2019)

Visual events are usually accompanied by sounds in our daily lives. However, can the machines learn to correlate the visual scene and sound, as well as localize the sound source only by observing them like humans? To investigate its empirical learnability, in this work we first present a novel unsupervised algorithm to address the problem of localizing sound sources in visual scenes. In order to achieve this goal, a two-stream network structure which handles each modality with attention mechanism is developed for sound source localization. The network naturally reveals the localized response in the scene without human annotation. In addition, a new sound source dataset is developed for performance evaluation. Nevertheless, our empirical evaluation shows that the unsupervised method generates false conclusions in some cases. Thereby, we show that this false conclusion cannot be fixed without human prior knowledge due to the well-known correlation and causality mismatch misconception. To fix this issue, we extend our network to the supervised and semi-supervised network settings via a simple modification due to the general architecture of our two-stream network. We show that the false conclusions can be effectively corrected even with a small amount of supervision, i.e., semi-supervised setup. Furthermore, we present the versatility of the learned audio and visual embeddings on the cross-modal content alignment and we extend this proposed algorithm to a new application, sound saliency based automatic camera view panning in 360-degree° videos.
Principles of tranfusion medicine (1996)

The red cell special problems of red cell transfusion the platelet special problems of platelet transfusion the white cell the plasma special problems of plasma component theory the bone marrow apheresis transfusion in the surgical patient haemostasis and surgery transfusion - transmitted diseases transfusion reactions tissue and organ banking organization of blood services.
Revisiting Complex Moments for 2-D Shape Representation and Image Normalization (2011)

When comparing 2-D shapes, a key issue is their normalization. Translation and scale are easily taken care of by removing the mean and normalizing the energy. However, defining and computing the orientation of a 2-D shape is not so simple. In fact, although for elongated shapes the principal axis can be used to define one of two possible orientations, there is no such tool for general shapes. As we show in the paper, previous approaches fail to compute the orientation of even noiseless observations of simple shapes. We address this problem and show how to uniquely define the orientation of an arbitrary 2-D shape, in terms of what we call its Principal Moments. We start by showing that a small subset of these moments suffices to describe the underlying 2-D shape, i.e., that they form a compact representation, which is particularly relevant when dealing with large databases. Then, we propose a new method to efficiently compute the shape orientation: Principal Moment Analysis. Finally, we discuss how this method can further be applied to normalize gray-level images. Besides the theoretical proof of correctness, we describe experiments demonstrating robustness to noise and illustrating with real images.
Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study (2017)

Together these findings suggest that FMR1 CGG repeat length may have a role in determining X-chromosome inactivation which could represent a possible mechanism for previously observed association of low age adjusted ovarian reserve with FMR1 variations in repeat length. Further, larger, investigations will be required to test this hypothesis.
Semantic part segmentation using compositional model combining shape and appearance (2015)

In this paper, we study the problem of semantic part segmentation for animals. This is more challenging than standard object detection, object segmentation and pose estimation tasks because semantic parts of animals often have similar appearance and highly varying shapes. To tackle these challenges, we build a mixture of compositional models to represent the object boundary and the boundaries of semantic parts. And we incorporate edge, appearance, and semantic part cues into the compositional model. Given part-level segmentation annotation, we develop a novel algorithm to learn a mixture of compositional models under various poses and viewpoints for certain animal classes. Furthermore, a linear complexity algorithm is offered for efficient inference of the compositional model using dynamic programming. We evaluate our method for horse and cow using a newly annotated dataset on Pascal VOC 2010 which has pixelwise part labels. Experimental results demonstrate the effectiveness of our method.
High performance quantum cascade laser frequency combs at λ ∼ 6 μm based on plasmon-enhanced dispersion compensation (2020)

We demonstrate quantum cascade laser (QCL) optical frequency combs emitting at λ ∼ 6 μm. A 5.5 μm-wide, 4.5 mm-long laser exhibits comb operation from -20 °C up to 50 °C. A maximum output power of 300 mW is achieved at 50 °C showing a robustness of the system. The laser output spectrum is ∼80 cm<sup>-1</sup> wide at the maximum current, with a mode spacing of 0.334 cm<sup>-1</sup>, resulting in a total of 240 modes with an average power of 0.8 mW per mode. To achieve frequency comb operation, a plasmonic-waveguide approach is utilized. A thin, highly-doped indium phosphide (InP) layer is inserted in the top cladding design to compensate the positive dispersion of the system (material and waveguide). This approach can be further exploited to design QCL combs at even shorter wavelengths, down to 4 μm. Different ridge widths between 2.8 and 5.5 μm have been fabricated and characterized. All of the devices exhibit frequency comb operation. These observations demonstrate that the plasmonic-waveguide is a robust and reliable method for dispersion compensation of a semiconductor laser systems to achieve frequency comb operation.
On the stability of chord-based P2P systems (2005)

The current generation of P2P networks is intended to provide cost-effective alternatives to the traditional client-server architecture. The main goal is to store and retrieve data in a decentralized manner. The challenge in doing so consists in creating a stable overlay network that allows for fast and efficient searches. In this paper we consider the Chord P2P algorithm in this context and analyze its stability and efficiency with stochastic methods. We present realistic probabilities for a disconnection and investigate the corresponding scalability.
Cytokine-specific induction of the TGF-? inducible early gene (TIEG): Regulation by specific members of the TGF-? family (2000)

Select members of the TGF-beta family of cytokines play key regulatory roles in skeletal development, structure, and turnover. This laboratory has previously reported that TGF-beta treatment of immortalized normal human fetal osteoblast (hFOB) cells results in the rapid induction of the mRNA levels of a TGF-beta inducible early gene (TIEG) followed by changes in cell proliferation and bone matrix protein production. Previous studies have also shown that nonmembers of the TGF-beta superfamily showed little or no induction of TIEG mRNA. This article further addresses the cytokine specificity of this TIEG induction by examining whether activin and select bone morphogenetic proteins, (BMP-2, BMP-4, and BMP-6), which are representative of different subfamilies of this superfamily, also induce the expression of TIEG in hFOB cells. However, TGF-beta remained the most potent of these cytokines, inducing TIEG mRNA steady-state levels at 0.1 ng/ml, with a maximum induction of 24-fold at 2.0 ng/ml. The BMP-2 (16-fold), BMP-4 (4-fold), and activin (1-3-fold) also induced TIEG mRNA levels, but at reduced degrees compared to TGF-beta (24-fold), and only at much higher cytokine concentrations, e.g., 50-100 ng/ml, compared to 2 ng/ml for TGF-beta. BMP-6 showed no effect on TIEG mRNA levels. The TIEG protein levels generally correlated with the mRNA steady-state levels. As with TGF-beta, BMP-2 treatment of hFOB cells was shown by confocal microscopy to induce a rapid translocation of the TIEG protein to the nucleus. In summary, the relative potencies of these TGF-beta family members to induce TIEG expression generally follows the general osteoinductive capacity of these cytokines, with TGF-beta >>> BMP-2 > BMP-4 > activin >> BMP-6.
Light-emitting diodes and laser diodes based on a Ga1−xInxAs/GaAs1−ySby type II superlattice on InP substrate (1999)

We report on the fabrication and characterization of light-emitting diodes (LEDs) and laser diodes with a staggered type II Ga1−xInxAs/GaAs1−ySby superlattice (SL) as the active region. SLs were grown strain compensated on the InP substrate using metalorganic chemical vapor deposition. The LEDs show room-temperature electroluminescence up to 2.14 μm, the index-guided diode lasers displayed cw laser emission at 1.71 μm up to 300 K. The spontaneous emission spectrum was found to show a significant blueshift with increasing injection current density, resulting in shorter laser emission wavelengths for the diode laser than for the LED.
Bioinformatics Programming Using Python: Practical Programming for Biological Data (2009)

Powerful, flexible, and easy to use, Python is an ideal language for building software tools and applications for life science research and development. This unique book shows you how to program with Python, using code examples taken directly from bioinformatics. In a short time, you'll be using sophisticated techniques and Python modules that are particularly effective for bioinformatics programming. Bioinformatics Programming Using Python is perfect for anyone involved with bioinformatics -- researchers, support staff, students, and software developers interested in writing bioinformatics applications. You'll find it useful whether you already use Python, write code in another language, or have no programming experience at all. It's an excellent self-instruction tool, as well as a handy reference when facing the challenges of real-life programming tasks. Become familiar with Python's fundamentals, including ways to develop simple applications Learn how to use Python modules for pattern matching, structured text processing, online data retrieval, and database access Discover generalized patterns that cover a large proportion of how Python code is used in bioinformatics Learn how to apply the principles and techniques of object-oriented programming Benefit from the tips and traps section in each chapter
Boosting laser-ion acceleration with multi-picosecond pulses (2017)

Using one of the world most powerful laser facility, we demonstrate for the first time that high-contrast multi-picosecond pulses are advantageous for proton acceleration. By extending the pulse duration from 1.5 to 6 ps with fixed laser intensity of 10<sup>18</sup> W cm<sup>-2</sup>, the maximum proton energy is improved more than twice (from 13 to 33 MeV). At the same time, laser-energy conversion efficiency into the MeV protons is enhanced with an order of magnitude, achieving 5% for protons above 6 MeV with the 6 ps pulse duration. The proton energies observed are discussed using a plasma expansion model newly developed that takes the electron temperature evolution beyond the ponderomotive energy in the over picoseconds interaction into account. The present results are quite encouraging for realizing ion-driven fast ignition and novel ion beamlines.
Adjuvant Systemic Therapy for Older Adults with Early-Stage Breast Cancer (2009)

There is a relative paucity of evidence to guide the adjuvant therapy of breast cancer in older adults. Herein, we review data from relevant clinical trials and retrospective analyses that assess systemic therapies in older adults. Chemotherapy, endocrine therapy, HER2-directed agents and bisphosphonates in the adjuvant setting are discussed. Meta-analyses, such as the Oxford overview, suggest a decreasing benefit of chemotherapy with age. However, prospective trials do support a benefit from the addition of chemotherapy to endocrine therapy in older adults. In contrast to chemotherapy, the value of endocrine therapy appears to increase with age. In addition, available subset analyses suggest that the benefit from aromatase inhibitors relative to tamoxifen is independent of age. The use of HER2-directed therapy in older adults is challenged by the relatively low enrollment of this subset in prospective clinical trials. Nonetheless, the extent of enrollment may be proportional to the frequency of HER2 overexpression in this population. Finally, there are little data to support the use of adjuvant bisphosphonate therapy in older adults--ongoing prospective trials may address this issue. Each of the aforementioned therapeutic strategies will be augmented by efforts to personalize therapy for older adults. Clinical tools such as the geriatric assessment and biologic assays, such as the 21-gene recurrence score, may ultimately play a role in treatment algorithms for this unique demographic.