gebhart/patrepeval huggingface dataset:
Split Federated Learning and Reinforcement based Codec Switching in Edge Platform (2023)

In recent times, Split Federated Learning (SFL) is being proposed in the domain of Artificial Intelligence (AI) & Machine Learning (ML), where AI/ML models are partitioned into two or more sub-networks among clients and servers (i.e., edge/cloud). However, in the SFL approach, it is not clear on what basis the AI/ML model is partitioned among the client and the edge. In a partial offload scenario, to mitigate this issue, we propose an Optimal Split Federated Learning (O-SFL) mechanism that finds an optimal split of a DNN model based on network bandwidth where no media data is transferred but only partial output of the model is shared among clients and the edge device. However, in full offload scenario, where media data is transferred from clients to edge, it is possible that the codec that is being currently used for encoding frames is not suitable due to the current network bandwidth fluctuations. To solve this issue, we propose a Reinforcement Learning based Codec Switching (RLCS) mechanism that provides a-priori detection of a suitable codec based on current networks bandwidth conditions. We perform simulations to compare the performance of the O-SFL which provides significant improvements over SFL (considering various split points) for total training time tested with Wi-Fi and LTE network (as 5G network is not available currently). We also show the performance of RLCS mechanism with respect to the traditional fixed video codec mechanism.
Simultaneous Analysis of Multiple Cytokines in the Vitreous of Patients with Sarcoid Uveitis (2012)

Patients with ocular sarcoidosis had elevated levels of proinflammatory cytokines in vitreous fluids. Different cytokines might contribute to different stages of macular edema.
Adrenergic regulation of intercellular communications between cultured striatal astrocytes from the mouse. (1991)

The permeability of gap junctions in cultured striatal astrocytes was investigated by the scrape-loading/dyetransfer technique. Prolonged application of norepinephrine (NE) (10 microM) reduced by half the extent of dye (Lucifer yellow) spread. This effect was linked to the activation of alpha 1-adrenergic receptors since it was mimicked by methoxamine and antagonized by prazosin. The adenosine agonist 2-chloroadenosine (10 microM), which potentiates the NE-evoked activation of phospholipase C (PLC) in striatal astrocytes, also potentiated the NE-evoked closure of gap junctions, the effect being as important as that observed with the uncoupling agent octanol. Measurements of inositol phospholipid turnover performed in identical experimental conditions revealed a close relationship between the extent of PLC activation and the magnitude of the uncoupling process. The effect of NE was mimicked by both phorbol ester and arachidonic acid, suggesting that biochemical events linked to PLC stimulation such as protein kinase C activation and/or eicosanoid production are likely involved in the NE-induced uncoupling. In addition, in the presence of a cAMP phosphodiesterase inhibitor, the stimulation of beta-adrenergic receptors by isoproterenol (10 microM) led to a large increase in cAMP accumulation correlated with an extension of dye diffusion. This observation suggests that junctional permeability could also be controlled by a cAMP-dependent mechanism. Altogether these results indicate that intercellular communication between cultured astrocytes can be regulated by different second messenger pathways as a result of the action of neurotransmitters on their receptors.
P.43: Model Development for Cell‐Gap Induced Mura to Improve Quality of Glass Substrates to Display Manufacturers (2013)

Abstract Implications of cell gap variations on LCD performance, particularly Mura, are discussed. A model combining light transmission through LCD and its perception is presented, including an application. Such a model can be used as a guide to define glass surface flatness performance needs to enable high quality displays.
Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells (2018)

A cute myeloid leukemia is a malignant disease of immature myeloid cells. Despite significant therapeutic effects of differentiation-inducing agents in some acute myeloid leukemia subtypes, the disease remains incurable in a large fraction of patients. Here we show that SK053, a thioredoxin inhibitor, induces differentiation and cell death of acute myeloid leukemia cells. Considering that thioredoxin knock-down with short hairpin RNA failed to exert antiproliferative effects in one of the acute myeloid leukemia cell lines, we used a biotin affinity probe-labeling approach to identify potential molecular targets for the effects of SK053. Mass spectrometry of proteins precipitated from acute myeloid leukemia cells incubated with biotinylated SK053 used as a bait revealed protein disulfide isomerase as a potential binding partner for the compound. Biochemical, enzymatic and functional assays using fluorescence lifetime imaging confirmed that SK053 binds to and inhibits the activity of protein disulfide isomerase. Protein disulfide isomerase knockdown with short hairpin RNA was associated with inhibition of cell growth, increased CCAAT enhancer-binding protein α levels, and induction of differentiation of HL-60 cells. Molecular dynamics simulation followed by the covalent docking indicated that SK053 binds to the fourth thioredoxin-like domain of protein disulfide isomerase. Differentiation of myeloid precursor cells requires the activity of CCAAT enhancer-binding protein α, the function of which is impaired in acute myeloid leukemia cells through various mechanisms, including translational block by protein disulfide isomerase. SK053 increased the levels of CCAAT enhancer-binding protein α and upregulated mRNA levels for differentiation-associated genes. Finally, SK053 decreased the survival of blasts and increased the percentage of cells expressing the maturation-associated CD11b marker in primary cells isolated from bone marrow or peripheral blood of patients with acute myeloid leukemia. Collectively, these results provide a proof-of-concept that protein disulfide isomerase inhibition has potential as a therapeutic strategy for the treatment of acute myeloid leukemia and for the development of small-molecule inhibitors of protein disulfide isomerase.
A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer (2021)

Palbociclib did not impact outcome in RB-intact mHSPC. Pretreatment CTC, TP53 and PIK3 pathway mutations, and 8q gain were associated with poor outcome.
Analysis and comparison of end effects in linear switched reluctance and hybrid motors (2017)

Abstract This paper presents and discusses the longitudinal and transversal end effects which affects the propulsive force of linear motors. Generally, the modeling of linear machine considers the forces distortion due to the specific geometry of linear actuators. The insertion of permanent magnets on the stator allows improving the propulsive force produced by switched reluctance linear motors. Also, the inserted permanent magnets in the hybrid structure allow reducing considerably the ends effects observed in linear motors. The analysis was conducted using 2D and 3D finite elements method. The permanent magnet reinforces the flux produced by the winding and reorients it which allows modifying the impact of end effects. Presented simulations and discussions show the importance of this study to characterize the end effects in two different linear motors.
A New Approach to the Study of Urinary Macromolecules as a Participant in Calcium Oxalate Crystallization (1988)

Despite intense investigation, the relationship of urinary proteins to urinary stone matrix formation remains poorly understood. In an attempt to gain more information regarding this interaction, the binding of urinary proteins to calcium oxalate crystals formed in urine in vitro was studied. 0.1 M calcium chloride and 0.1 M sodium oxalate were added to an aliquot of urine collected from five non-infected, non-stone forming males. The resulting calcium oxalate crystals were centrifuged and the pellet demineralized with 5% EDTA. Gel filtration chromatography was used to isolate the protein fraction from the urine samples before and after crystallization of calcium oxalate. The proteins recovered from the crystals and urine were separated by two-dimensional polyacrylamide gel electrophoresis. Many, but not all of the urinary proteins were bound by the crystals. Albumin, seen to the most abundant urinary protein, was absent or markedly diminished in all instances, and the second most abundant urinary protein, PC-30, became the predominant protein component of the crystals. An unidentified protein with approximate molecular weight of 22,000 daltons and isoelectric point of 6.4 was highly concentrated by the crystals even when undetected in the urine. The study suggests that the binding of urinary proteins to calcium oxalate crystals formed in urine in vitro is not a random event but rather a selective phenomenon.
Quantitation of mitral regurgitation by Doppler echocardiography. (1986)

The evaluation and care of patients with mitral regurgitation would be facilitated by an easy, reproducible and noninvasive method that could quantitate the hemodynamic burden. In this study, we describe a new Doppler echocardiographic method that measures the regurgitant fraction and we compare it with angiographic and scintigraphic methods. A total of 27 patients with mitral regurgitation were evaluated by echocardiography and either cardiac catheterization or scintigraphy. With two-dimensional echocardiography, diastolic and systolic volumes were measured to derive the left ventricular stroke volume (LVSV). The forward stroke volume (FSV) was obtained from the product of M mode-derived aortic valve area and ascending aortic flow velocity integral assessed by continuous-wave Doppler. Regurgitant fraction was calculated as follows: (LVSV - FSV)/LVSV. Comparisons showed that regurgitant fraction calculated by Doppler echocardiography correlated with regurgitant fraction determined by both cardiac catheterization (r = .82) and by scintigraphy (r = .89). There was, however, an important interobserver variability within each method: 10%, 13%, and 11% for Doppler echocardiography, angiography, and scintigraphy, respectively. In conclusion, Doppler echocardiography can be used to quantitate mitral regurgitation. Serial noninvasive determinations of regurgitant fraction may be useful in the evaluation of therapy and in the follow-up of patients with mitral insufficiency.
Zeroth-order shape optimization utilizing a learning classifier system (1996)

A methodology to perform generalized zeroth-order two- and three-dimensional shape optimization utilizing a learning classifier system is developed and applied. To this end, the applicability of machine learning to mechanical engineering is investigated. Specifically, the methodology has the objective of determining the optimal boundary to minimize mass while satisfying constraints on stress and geometry.
Even with the enormous advances in shape optimization no method has proven to be satisfactory across the broad spectrum of optimization problems facing the modern engineer. The methodology developed in this dissertation is based upon a classifier system (CS) and exploits the CS's adaptability and generality. It thereby overcomes many of the limitations of today's conventional shape optimization techniques. A CS learns rules, postulated as if-then statements, in order to improve its performance in an arbitrary environment, (which for this investigation consists of stress and mass information from components). From this input, and from a population of initially randomly generated rules, the classifier system is expected to learn to make the appropriate component shape modifications to reach a minimum mass design while satisfying all stress constraints. The CS learns by utilizing the design improvement success or failure feedback.
After a review of mechanical engineering shape optimization methods, an explanatory presentation of CSs and their underlying genetic algorithm (GA) describes how classifier systems learn from feedback and the GA. With this foundation set, the coupling of the shape optimization domain with the classifier system proceeds to form, the Shape oPtimization via Hypothesizing Inductive classifier system compleX (SPHINcsX). The complex learns shape optimization by its application to a suite of sizing optimization problems.
The most tangible artifact of this research is the successful development of the zeroth-order shape optimization complex. The complex proved adept at solving both two- and three-dimensional shape optimization problems. The research also provides a demonstrative example of the power and flexibility of machine learning in general and CSs in particular--how they may be leveraged as tools for mechanical engineering design, and insights into their proper application.
Intensity Noise Coupling in Soliton Fiber Oscillators (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Wan, T. Schibli, P. Li, C. Bevilaqua, A. Ruehl, and I. Hartl, "Intensity Noise Coupling in Soliton Fiber Oscillators," in Conference on Lasers and Electro-Optics, OSA Technical Digest (2016) (Optica Publishing Group, 2016), paper STh3O.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Nachweis der Liganden-induzierten Bewegung der beiden Domänen von Glucoamylase G1 ausAspergillus niger durch dynamische Lichtstreuung unter Verwendung heterobifunktioneller Substratanaloga (1999)

Heterobifunktionelle Liganden, die gleichzeitig an die Katalysedomäne und an die Stärkebindungsdomäne von Glucoamylase binden, induzieren eine Konformationsänderung des Proteins, wie mit dynamischer Lichtstreuung gezeigt wurde. Die Liganden bestehen aus Acarbose und β-Cyclodextrin, die über Oligoethylenglycol-Linker unterschiedlicher Länge miteinander verbunden sind (siehe schematische Darstellung).
A Collaborative Approach to Advance Student Research at the University of Southern California (2012)

The continued advancement of oral health and science relies upon the cultivation of a student's interest in research. The Student Research Group at the Ostrow School of Dentistry of the University of Southern California is working to increase student involvement in research and develop future academic leaders. This study aims to, through student surveys, quantitatively evaluate students' involvement in research, students' interest in participating in research and to identify specific barriers students feel challenge their ability to participate in research.
Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro (2019)

Ebola virus is the causative agent of Ebola virus disease, a severe, often fatal illness in humans. So far, there are no US Food and Drug Administration (FDA)-approved therapeutics directed against Ebola virus. Here, we selected the host factor Niemann-Pick C1 (NPC1), which has been shown to be essential for Ebola virus entry into host cytoplasm, as a therapeutic target for suppression by locked nucleic acid-modified antisense oligonucleotides. Screening of antisense oligonucleotides in human and murine cell lines led to identification of candidates with up to 94% knockdown efficiency and 50% inhibitory concentration (IC<sub>50</sub>) values in the submicromolar range. Selected candidate oligonucleotides led to efficient NPC1 protein knockdown in vitro without alteration of cell viability. Furthermore, they did not have immune stimulatory activity in cell-based assays. Treatment of Ebola-virus-infected HeLa cells with the most promising candidates resulted in significant (>99%) virus titer reduction, indicating that antisense oligonucleotides against NPC1 are a promising therapeutic approach for treatment of Ebola virus infection.
[Kennedy's disease: expansion of the CAG trinucleotide]. (2001)

Kennedy's disease is a rare X-linked spinal and bulbar muscular atrophy (SBMA). A degenerative process of the motor neurons is associated with an increase in the number of CAG repeats encoding a polyglutamine stretch within the androgen receptor. Despite a distinctive clinical phenotype, SBMA can be misdiagnosed, usually due to the lack of clear family history. Accurate diagnosis is important for genetic counseling and because alternative diagnosis of amyotrophic lateral sclerosis usually means much worse prognosis. We report 2 unrelated patients with Kennedy's disease in whom the clinical diagnosis was confirmed by showing the CAG repeat expansion.
Infrared focal-plane array crosstalk measurement (1992)

Crosstalk between two neighboring elements in a focal plane array (FPA) occurs when signal incident on one element in the array is seen on another. This undesired effect can occur due to both the electrical and optical properties of the FPA. An effort is underway at the U.S. Army's Night Vision and Electro-Optics Directorate to develop a capability to measure crosstalk on both mid-wave infrared and long-wave infrared FPAs. A single detector in an array is illuminated using a laser source coupled with a beam expander, collimating lens, and focusing lens. The relative response of that detector to that of its neighboring detectors is measured to calculate crosstalk. The various components of the test station, the methodology for implementing the crosstalk measurement, and a model of the laser spot size are discussed.
Synthesis and Characterization of Iodinated Tetrahydroquinolines Targeting the G Protein-Coupled Estrogen Receptor GPR30 (2009)

A series of iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines was synthesized as potential targeted imaging agents for the G protein-coupled estrogen receptor GPR30. The affinity and specificity of binding to GPR30 versus the classical estrogen receptors ER alpha/beta and functional responses associated with ligand-binding were determined. Selected iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines exhibited IC(50) values lower than 20 nM in competitive binding studies with GPR30-expressing human endometrial cancer cells. These compounds functioned as antagonists of GPR30 and blocked estrogen-induced PI3K activation and calcium mobilization. The tributylstannyl precursors of selected compounds were radiolabeled with (125)I using the iodogen method. In vivo biodistribution studies in female ovariectomized athymic (NCr) nu/nu mice bearing GPR30-expressing human endometrial tumors revealed GPR30-mediated uptake of the radiotracer ligands in tumor, adrenal, and reproductive organs. Biodistribution and quantitative SPECT/CT studies revealed structurally related differences in the pharmacokinetic profiles, target tissue uptake, and metabolism of the radiolabeled compounds as well as differences in susceptibility to deiodination. The high lipophilicity of the compounds adversely affects the in vivo biodistribution and clearance of these radioligands and suggests that further optimization of this parameter may lead to improved targeting characteristics.
Thin EFG Octagons: Annual Subcontract Report, 1 April 1992 - 31 March 1993 (1994)

Mobil Solar Energy Corporation currently practices a unique crystal growth technology for producing crystalline silicon sheet, which is then cut with lasers into wafers. The wafers are processed into solar cells and incorporated into modules for photovoltaic applications. The silicon sheet is produced using a method known as Edge-defined Film-fed growth (EFG), in the form of hollow eight-sided polygons (octagons) with 10 cm faces. These are grown to lengths of 5 meters and thickness of 300 microns, with continuous melt replenishment, in compact furnaces designed to operate at a high sheet area production area of 135 cm{sup 2}/min. The present Photovoltaic Manufacturing Technology (PVMaT) three-year program seeks to advance the manufacturing line capabilities of the Mobil Solar crystal growth and cutting technologies. If successful, these advancements will provide significant reductions in already low silicon raw material usage, improve process productivity, laser cutting throughput and yield, and so lower both individual wafer cost and the cost of module production. This report summarizes the significant technical improvements in EFG technology achieved in Phase 1 of this program. Technical results are reported for each of the three main program areas: (1) thin octagon growth (crystal growth) -- to reduce the thickness of the octagon to an interim goal of 250 microns during Phase 1, with an ultimate goal of achieving 200 micron thicknesses; (2) laser cutting -- to improve the laser cutting process, so as to produce wafers with decreased laser cutting damage at increased wafer throughput rates; and (3) process control and product specification -- to implement advanced strategies in crystal growth process control and productivity designed to increase wafer yields.
A New Formula-Based Measurement Guide for Optimal Positioning of Central Venous Catheters (2004)

Abstract Purpose: To validate the formula-based central venous catheter (CVC) length measurement “tailored” to individual's height and access site for predicting optimum SVC tip position. Method: A prospective study of 3 percutaneous insertion sites (PICC, SCC and JC). Formula-based “LUM'S CVC MEASUREMENT GUIDE” was used to determine the catheter length. Results: Overall, 97% (373) of the total 382 insertions were successfully placed with CVC tip in the distal SVC (SVC between carina and atrio-cava junction) location. Conclusion: The “tailored fit” formula to individual patient height is a reliable tool to predict CVC length. Appropriate catheter length can greatly reduce the guesswork and possibility of complications related to tip malposition.
An English-to-Arabic Prototype Machine Translator for Statistical Sentences (2012)

Authors of that paper proposed a prototype machine translator system to translate scientific English sentences into Ara- bic sentences. This system is based on natural language processing and machine learning. This proposed system is ap- plied in statistical field, which is very important on a mathematical sub field in Math department. The system is ana- lyzed, designed and developed. Author tested the proposed system on some statistical statements. It proves its validity as a prototype system.
Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderly: The AGES-Reykjavik study (2013)

Finger length patterns read from digital photographs in this large study confirm previous radiographic observations with significant associations between the type 3 pattern and total knee replacements but not total hip replacements in both genders in this elderly group.