gebhart/patrepeval huggingface dataset:
Peptide sequence determination of peptidosteroids on a single bead by electrospray ionization-mass spectroscopy (2002)

An electrospray ionization mass spectroscopy (ESI-MSn) method has been developed to simultaneously determine the sequence of two strands of tripeptides attached to a steroid-like scaffold. The peptidosteroid compounds were synthesized by solid-phase chemistry on TentaGel beads. The sequence of both peptide strands of a compound originating from a single bead could be determined. High-performance liquid chromatography hyphenated to MSn was also applied to a mixture of two isomeric peptidosteroids for sequence determination of their peptide chains.
Die Ehe des Propheten Hosea; Eine auslegungsgeschichtliche Untersuchung (1978)

Book Review| March 01 1978 Die Ehe des Propheten Hosea; Eine auslegungsgeschichtliche Untersuchung Die Ehe des Propheten Hosea; Eine auslegungsgeschichtliche Untersuchung, Stephan Bitter. Martin J. Buss Martin J. Buss Search for other works by this author on: This Site Google Journal of Biblical Literature (1978) 97 (1): 132–133. https://doi.org/10.2307/3265858 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Martin J. Buss; Die Ehe des Propheten Hosea; Eine auslegungsgeschichtliche Untersuchung. Journal of Biblical Literature 1 March 1978; 97 (1): 132–133. doi: https://doi.org/10.2307/3265858 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Copyright 1978 Society of Biblical Literature1978 Article PDF first page preview Close Modal You do not currently have access to this content.
A carrier frequency offset correction scheme for MC-CDMA (2002)

A novel algorithm for carrier frequency offset correction in MC-CDMA is investigated. The algorithm uses coherently detected data symbols to provide phase offset information, which is used to modify the carrier frequency and successively reduce the offset with every data symbol. Comparison between this frequency correction algorithm, a closely related phase compensation algorithm and a two-symbol maximum likelihood estimation algorithm is provided.
Tissue engineering: strategies, stem cells and scaffolds (2008)

Tissue engineering scaffolds are designed to influence the physical, chemical and biological environment surrounding a cell population. In this review we focus on our own work and introduce a range of strategies and materials used for tissue engineering, including the sources of cells suitable for tissue engineering: embryonic stem cells, bone marrow-derived mesenchymal stem cells and cord-derived mesenchymal stem cells. Furthermore, we emphasize the developments in custom scaffold design and manufacture, highlighting laser sintering, supercritical carbon dioxide processing, growth factor incorporation and zoning, plasma modification of scaffold surfaces, and novel multi-use temperature-sensitive injectable materials.
N2gas is an effective fertilizer for bioethanol production byZymomonas mobilis (2015)

A nascent cellulosic ethanol industry is struggling to become cost-competitive against corn ethanol and gasoline. Millions of dollars are spent on nitrogen supplements to make up for the low nitrogen content of the cellulosic feedstock. Here we show for the first time to our knowledge that the ethanol-producing bacterium, Zymomonas mobilis, can use N2 gas in lieu of traditional nitrogen supplements. Despite being an electron-intensive process, N2 fixation by Z. mobilis did not divert electrons away from ethanol production, as the ethanol yield was greater than 97% of the theoretical maximum. In a defined medium, Z. mobilis produced ethanol 50% faster per cell and generated half the unwanted biomass when supplied N2 instead of ammonium. In a cellulosic feedstock-derived medium, Z. mobilis achieved a similar cell density and a slightly higher ethanol yield when supplied N2 instead of the industrial nitrogen supplement, corn steep liquor. We estimate that N2-utilizing Z. mobilis could save a cellulosic ethanol production facility more than $1 million/y.
Venetoclax after idelalisib: relevant progress for CLL (2018)

Coutre et al conducted a multicenter phase 2 study on the use of venetoclax for patients with chronic lymphocytic leukemia (CLL) progressing during or after treatment with idelalisib or ibrutinib. In this issue of Blood, they report the results in 36 patients who received idelalisib as their last therapy.1 Treatment with venetoclax resulted in a high objective response rate (67%) and an estimated progression-free survival of 79% at 12 months, while reporting only moderate toxicity.
Regulatory effect of MiR103 on proliferation, EMT and invasion of oral squamous carcinoma cell through SALL4. (2019)

The article "Regulatory effect of MiR103 on proliferation, EMT and invasion of oral squamous carcinoma cell through SALL4, by X. Liu, Y. Cao, Y. Zhang, H. Zhou, H. Li, published in Eur Rev Med Pharmacol Sci 2019; 23 (22): 9931-9938-DOI: 10.26355/eurrev_201911_19559-PMID: 31799662" has been withdrawn from the authors due to the fact that "some work cannot be repeated in the present paper". The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19559.
Time-interleaved oversampling A/D converters: theory and practice (1997)

In this paper, the design procedure and practical issues regarding the realization of time-interleaved oversampling converters are presented. Using the concept of block digital filtering, it is shown that arbitrary /spl Delta//spl Sigma/ topologies can be converted into corresponding time-interleaved structures. Practical issues such as finite opamp gain, mismatching, and DC offsets are addressed, analyzed, and practical solutions to overcome some of these problems are discussed. To verify the theoretical results, a discrete-component prototype of a second-order time-interleaved /spl Delta//spl Sigma/ analog/digital (A/D) converter has been implemented and the design details as well as experimental results are presented.
Hybrid Silicon Photonics for Optical Interconnects (2010)

In this paper, we review the hybrid silicon photonic integration platform and its use for optical links. In this platform, a III/V layer is bonded to a fully processed silicon-on-insulator wafer. By changing the bandgap of the III/V quantum wells (QW), low-threshold-current lasers, high-speed modulators, and photodetectors can be fabricated operating at wavelengths of 1.55 μm. With a QW intermixing technology, these components can be integrated with each other and a complete high-speed optical interconnect can be realized on-chip. The hybrid silicon bonding and process technology are fully compatible with CMOS-processed wafers because high-temperature steps and contamination are avoided. Full wafer bonding is possible, allowing for low-cost and large-volume device fabrication.
Boosted ECOC ensembles for face recognition (2003)

The error correcting output coding (ECOC) approach to classifier design decomposes a multi-class problem into a set of complementary two-class problems. In this paper ECOC is combined with boosting using decision tree base classifiers to solve two problems in face recognition. Boosted ECOC ensembles using decision stumps and C4.5 classifiers are compared for face identification and verification.
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel (2016)

With the emergence of highly pathogenic avian influenza (HPAI) H7N9 and H5N1 strains, there is a pressing need to develop direct-acting antivirals (DAAs) to combat such deadly viruses. The M2-S31N proton channel of the influenza A virus (A/M2) is one of the validated and most conserved proteins encoded by the current circulating influenza A viruses; thus, it represents a high-profile drug target for therapeutic intervention. We recently discovered a series of S31N inhibitors with the general structure of adamantyl-1-NH2(+)CH2-aryl, but they generally had poor physical properties and some showed toxicity in vitro. In this study, we sought to optimize both the adamantyl as well as the aryl/heteroaryl group. Several compounds from this study exhibited submicromolar EC50 values against S31N-containing A/WSN/33 influenza viruses in antiviral plaque reduction assays with a selectivity index greater than 100, indicating that these compounds are promising candidates for in-depth preclinical pharmacology.
Utilizing Parasitic Capacitance of Single‐Droplet Electricity Generator For Specific Bacterial Detection (2023)

Abstract Single‐droplet electricity generator (SDEG) has superior potential over other solid–liquid triboelectric nanogenerators (TENGs) for energy harvesting. However, its shunting effect of parasitic capacitance is adverse and unavoidable, resulting in the reduction of the SDEG voltage. In addition, TENG‐based bacterial biosensors are still facing issues of incompetence in resolution, precision, and specificity. Therefore, a novel SDEG‐based bacterial biosensor is developed by making use of parasitic capacitance. By taking the advantages of aptamer and parasitic capacitance, the Pseudomonas aeruginosa ( P. aeruginosa ) can be specifically and precisely detected via signal change from a single droplet without energy accumulation. This study proves that the SDEG‐based bacterial biosensor exhibits an excellent performance for P . aeruginosa detection in low limit of detection (4.5×10 3 CFU mL −1 ) with high selectivity. Meanwhile, the established mathematical model yields consistent results to the experimental ones, which serves as a solid basis for quantifying bacterial concentration. This work contributes to TENG‐based bacterial biosensor, and opens up a new way for the diversified application of SDEG.
A Photonic Switching Demonstration Display (1987)

As fiber optic communication proliferates, it becomes important to explore the possibilities of photonic switching. As a near-term photonic switching technology, titanium-diffused lithium niobate ( Ti : LiNbO 3 ) needs to be evaluated by its use in experimental systems. In this display, a Ti : LiNbO 3 array switches video from cameras to monitors.
Alcohol and premature death rates of the population of Tomsk Region (2010)

The role of the alcoholic factor in structure of death rate of the population of Tomsk area is studied. At pathology-anatomic research alcohol in blood was found out in 38,9% of cases. This parameter remains rather stable during of some years while death rate from a poisoning with ethyl spirit last three years has decreased almost on third. The given parameter speaks about essential underestimation of the alcoholic factor in structure of death rate. At carrying out of examinations and researches of corpses of nonviolent death ethyl spirit has been found out in 18,4%. These data draw attention to alchohol-dependent diseases of internal bodies. Other picture comes to light at the analysis of the alcoholic factor in structure of violent death rate. For 2007 at carrying out of examinations and researches of corpses of a violent death ethyl spirit has been found out in 63,2% of cases. The greatest contribution of the alcoholic factor is revealed at such reasons of death, as a poisoning with carbonic oxide (69,7%), action of low temperatures (67,4%), road and transport incidents (48,5%).
THE INTRAPERITONEAL ADMINISTRATION OF NEO-ARSPHENAMIN (1924)

The intraperitoneal administration of fluids, such as physiologic sodium chlorid solution,1glucose,2and sodium bicarbonate,3in the treatment of the diarrheas and the acidoses of infancy, is already established as the method of choice in certain selected instances in which the usual procedures of intravenous, intramuscular and subcutaneous injections are not practical, for well known reasons. Transfusion4by the intraperitoneal route has recently been revived, and is now used in the treatment of certain conditions in infancy. That the peritoneum serves as an absorbing membrane can no longer be questioned. However, in intra-peritoneal therapy, it is essential to determine the reaction on the part of the peritoneum to the solution administered, as this reaction varies under certain definite conditions and may result in temporary or permanent injury of the mesothelial cells. Should permanent injury of the mesothelial cells occur, as is evidenced by failure of the
The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease (2023)

Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be fully harnessed to generate ATP or to become the building block of new biomolecules. Given the requirement for mitochondrial import, it is not surprising that the mitochondrial pyruvate carrier (MPC) has emerged as a target for therapeutic intervention in a variety of diseases characterized by altered mitochondrial and intermediary metabolism. In this review, we focus on the role of the MPC and related metabolic pathways in the liver in regulating hepatic and systemic energy metabolism and summarize the current state of targeting this pathway to treat diseases of the liver. Available evidence suggests that inhibiting the MPC in hepatocytes and other cells of the liver produces a variety of beneficial effects for treating type 2 diabetes and nonalcoholic steatohepatitis. We also highlight areas where our understanding is incomplete regarding the pleiotropic effects of MPC inhibition.
<title>Incremental motion encoder: a sensor for the integrated condition monitoring of rolling element bearings in machine tools</title> (1995)

Modern industry increasingly demands that machine tools operate continuously as elements within computer integrated manufacturing cells. Accurate monitoring of machine condition is the key to predicting failures that would result in quality defects or costly unplanned production stoppages. This paper presents research into the use of a novel rotary motion sensor for the condition monitoring of rolling element bearings. This sensor, the incremental motion encoder (IME), is based upon a patented development of the optical encoder commonly used in machine tools for sensing angular position and rotational speed. The IME combines these measurements with that of shaft center position in two dimensions. This motion of the shaft center is directly related to the condition of the bearings supporting the shaft. To illustrate the IME principle experimental results showing the ability of the sensor to distinguish between bearing defects and external sources of vibration are presented. Measurement of shaft loading with the sensor is also described. Currently machine tool condition is most often measured by external sensors, such as accelerometers or acoustic emission transducers, which are not parts of the machine itself. The IME is ideally suited to being designed into a machine tool so as to integrate a condition monitoring facility into the computer control of the machine. The paper concludes by describing the current technology which allows sensors based on the IME principle to be integrated directly into rolling element bearings for this purpose.
Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study (2017)

Avelumab showed an acceptable safety profile and clinical activity in a subset of patients with MBC. PD-L1 expression in tumor-associated immune cells may be associated with a higher probability of clinical response to avelumab in MBC.
Predicting Passive Permeability of Drug-like Molecules from Chemical Structure: Where Are We? (2016)

Intestinal absorption in human is routinely predicted in drug discovery using in vitro assays such as permeability in the Madin-Darby canine kidney cell line. In silico models trained on these data are used in drug discovery efforts to prioritize novel chemical targets for synthesis; however, their proprietary nature and the limited validation available, which is usually restricted to predicting in vitro permeability, are barriers to widespread adoption. Because of the categorical nature of the in vitro permeability assay, intrinsic assay variability, and the challenges often encountered when translating in vitro data to an in vivo drug property, validation based solely on in vitro data might not be a good characterization of the usefulness of the in silico tool. In this work, we analyze the performance of three different in silico models in predicting the in vitro and in vivo permeability of 300 marketed drugs and 86 discovery compounds. The models differ in their approach (mechanistic vs quantitative structure-activity relationship) and the degree of complexity; one of them is a linear equation based on seven simple physicochemical descriptors and is presented for the first time in this work. Results show that in silico models can be successfully used to complement the discovery toolbox for characterizing in vivo intestinal permeability, defined using fraction of dose absorbed in human (Fa) and human jejunal permeability (P<sub>eff</sub>). While the in vitro permeability models outperformed the in silico approach at predicting each of the in vivo end points explored, the gap in predictivity between the in vitro and the in vivo data was generally comparable to the gap between in silico and in vitro data. The in vitro and in silico approaches shared many of the same outliers, which can often be explained by the route of drug absorption (paracellular vs transcellular, active vs passive). Data suggest that the discovery process can greatly benefit from an early adoption of in silico models for predicting permeability as well as from a careful analysis of the in silico to in vivo disconnects.
Effect of oil on an electrowetting lenticular lens and related optical characteristics (2017)

While there are many ways to realize autostereoscopic 2D/3D switchable displays, the electrowetting lenticular lens is superior due to the high optical efficiency and short response time. In this paper, we propose a more stable electrowetting lenticular lens by controlling the quantity of oil. With a large amount of oil, the oil layer was broken and the lenticular lens was damaged at relatively low voltage. Therefore, controlling the amount of oil is crucial to obtain the required dioptric power with stability. We proposed a new structure to evenly adjust the volume of oil and the dioptric power was measured by varying the volume of oil. Furthermore, the optical characteristics were finally analyzed in the electrowetting lenticular lens array with a proper amount of oil.
Parasites and Phytoplankton, with Special Emphasis on Dinoflagellate Infections1 (2004)

Planktonic members of most algal groups are known to harbor intracellular symbionts, including viruses, bacteria, fungi, and protozoa. Among the dinoflagellates, viral and bacterial associations were recognized a quarter century ago, yet their impact on host populations remains largely unresolved. By contrast, fungal and protozoan infections of dinoflagellates are well documented and generally viewed as playing major roles in host population dynamics. Our understanding of fungal parasites is largely based on studies for freshwater diatoms and dinoflagellates, although fungal infections are known for some marine phytoplankton. In freshwater systems, fungal chytrids have been linked to mass mortalities of host organisms, suppression or retardation of phytoplankton blooms, and selective effects on species composition leading to successional changes in plankton communities. Parasitic dinoflagellates of the genus Amoebophrya and the newly described Perkinsozoa, Parvilucifera infectans, are widely distributed in coastal waters of the world where they commonly infect photosynthetic and heterotrophic dinoflagellates. Recent work indicates that these parasites can have significant impacts on host physiology, behavior, and bloom dynamics. Thus, parasitism needs to be carefully considered in developing concepts about plankton dynamics and the flow of material in marine food webs.
Discovery of putative salivary biomarkers for Sjögren’s syndrome using high resolution mass spectrometry and bioinformatics (2012)

The purpose of the current study was to determine if saliva contains biomarkers that can be used as diagnostic tools for Sjögren's syndrome (SjS). Twenty seven SjS patients and 27 age-matched healthy controls were recruited for these studies. Unstimulated glandular saliva was collected from the Wharton's duct using a suction device. Two µl of salvia were processed for mass spectrometry analyses on a prOTOF 2000 matrix-assisted laser desorption/ionization orthogonal time of flight (MALDI O-TOF) mass spectrometer. Raw data were analyzed using bioinformatic tools to identify biomarkers. MALDI O-TOF MS analyses of saliva samples were highly reproducible and the mass spectra generated were very rich in peptides and peptide fragments in the 750-7,500 Da range. Data analysis using bioinformatic tools resulted in several classification models being built and several biomarkers identified. One model based on 7 putative biomarkers yielded a sensitivity of 97.5%, specificity of 97.8% and an accuracy of 97.6%. One biomarker was present only in SjS samples and was identified as a proteolytic peptide originating from human basic salivary proline-rich protein 3 precursor. We conclude that salivary biomarkers detected by high-resolution mass spectrometry coupled with powerful bioinformatic tools offer the potential to serve as diagnostic/prognostic tools for SjS.
Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter? (2015)

In this large-scale evaluation of adults who received intermediate/high-risk regimens for solid tumors or NHL in US clinical practice, FN incidence was found to be significantly higher among those who received pegfilgrastim prophylaxis on the same day as chemotherapy completion versus days 2-4 from chemotherapy completion, underscoring the importance of adhering to the indicated administration schedule.
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor. (1996)

Diphosphoinositol pentakisphosphate (PP-IP5) and bis(diphospho)inositol tetrakisphosphate (bis-PP-IP4) are recently identified inositol phosphates that possess pyrophosphate bonds. We have purified an inositol hexakisphosphate (IP6) kinase from rat brain supernatants. The pure protein, a monomer of 54 kDa, displays high affinity (Km = 0.7 microM) and selectivity for inositol hexakisphosphate as substrate. It can be dissociated from bis(diphospho)inositol tetrakisphosphate synthetic activity. The purified enzyme transfers a phosphate from PP-IP5 to ADP to form ATP. This ATP synthase activity indicates the high phosphate group transfer potential of PP-IP5 and may represent a physiological role for PP-IP5.
Optical switching experiment in phase-shifted fiber Bragg gratings (2003)

We report results of an all-optical switching experiment in a phase-shifted fiber Bragg grating. A low power, CW probe beam is switched off (on) by an intense pump beam. We experimentally demonstrated the cross phase based, all-optical switching in a phase-shifted grating. The strong enhancement of the nonlinear effect due to the group velocity reduction and the switching polarization dependence was observed and theoretically confirmed.