gebhart/patrepeval huggingface dataset:
Spherical acoustic resonators in the undergraduate laboratory (1989)

A spherical acoustic resonator is reported that measures the speed of sound in gases with very high accuracy using comparatively simple instrumentation. The resonator can be used to illustrate, in a quantitative fashion, the temperature and pressure dependence of the speed of sound, the effects of thermal conductivity, and the splitting of nearly degenerate modes.
Atypical Disease after Bordetella pertussis Respiratory Infection of Mice with Targeted Disruptions of Interferon-γ Receptor or Immunoglobulin μ Chain Genes (1997)

Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that B. pertussis respiratory infection of mice with targeted disruptions of the genes for the IFN-gamma receptor resulted in an atypical disseminated disease which was lethal in a proportion of animals, and was characterized by pyogranulomatous inflammation and postnecrotic scarring in the livers, mesenteric lymph nodes and kidneys. Viable virulent bacteria were detected in the blood and livers of diseased animals. An examination of the course of infection in the lung of IFN-gamma receptor-deficient, IL-4-deficient and wild-type mice demonstrated that lack of functional IFN-gamma or IL-4, cytokines that are considered to play major roles in regulating the development of Th1 and Th2 cells, respectively, did not affect the kinetics of bacterial elimination from the lung. In contrast, B cell-deficient mice developed a persistent infection and failed to clear the bacteria after aerosol inoculation. These findings demonstrate an absolute requirement for B cells or their products in the resolution of a primary infection with B. pertussis, but also define a critical role for IFN-gamma in containing bacteria to the mucosal site of infection.
Hypertrophic Cardiomyopathy and Dysregulation of Cardiac Energetics in A Mouse Model of Biliary Fibrosis (2010)

Three weeks of DDC feeding-induced biliary fibrosis leads to multiple functional, metabolic, electrophysiological, and hypertrophic adaptations in the mouse heart, recapitulating some of the features of human cirrhotic cardiomyopathy.
Conjugated Estrogen/Bazedoxifene Tablets for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated with Menopause (2014)

Conjugated estrogen/bazedoxifene (CE/BZA) therapy represents a new, progestin-free treatment in the management of postmenopausal health. CE/BZA pairs CE with the selective estrogen receptor modulator, BZA. The rationale for the development of CE/BZA was that BZA, acting primarily as a selective estrogen receptor degrader in uterine and breast tissue, would sufficiently inhibit the proliferative effects of CE on the endometrium. The absence of a progestin would reduce the incidence of uterine bleeding, breast pain and increased breast density associated with progestin-containing hormone therapy. CE/BZA has been evaluated in five multicenter, randomized, double-blind, placebo-controlled, and active-controlled Phase III trials known as the SMART trials. CE/BZA has been shown to maintain the established benefits of estrogen therapy for treatment of vasomotor symptoms and prevention of a loss in bone mineral density (bone mass), while minimizing certain estrogenic effects, particularly in the uterine endometrium and breast.
CC.—A synthesis of pyrylium salts of anthocyanidin type. Part XV. The synthesis of cyanidin chloride by means of O-benzoylphloroglucinaldehyde (1928)

A. Robertson and R. Robinson, J. Chem. Soc., 1928, 1526 DOI: 10.1039/JR9280001526
Improvement of Submerged Doppler-Type Directional Wave Meter and Its Application to Field Observations (1997)

This paper presents an improved submerged Doppler-type directional wave meter which has the capability of measuring water surface elevations and multiple current velocity components. These components are determined from Doppler frequency shifts of ultrasonic waves in water. The improved system has proven to be capable of successfully obtaining tide, current and directional wave data. In addition, this directional wave meter has accurately estimated directional wave spectra in severe sea conditions with the use of some techniques introduced in this paper.
Combined adaptive modulation and transmitter diversity using long range prediction for flat fading mobile radio channels (2002)

Development of novel signal processing and communication techniques for 3G wireless systems is motivated by high data rate service requirements. These techniques include adaptive modulation and transmitter antenna diversity. In rapidly time variant channels, these methods need the knowledge of future fading conditions. Thus, they require accurate long range fading prediction. We investigate three combined adaptive modulation and transmitter diversity schemes in conjunction with our previously proposed long range channel prediction (LRP) algorithm. It is demonstrated that the novel combined schemes can achieve higher data rates than the conventional adaptive modulation methods when aided by the LRP.
Long Term Association of the Cytokine Receptor gp130 and the Janus Kinase Jak1 Revealed by FRAP Analysis (2003)

Signal transduction through cytokine receptors is mediated mainly by non-covalently associated Jak tyrosine kinases. By confocal microscopy, the cytokine receptor gp130 and Jak1, fused with either yellow (YFP) or cyan (CFP) fluorescent protein, were found to be colocalized predominantly at intracellular vesicular structures and at the plasma membrane. Quantitative fluorescence recovery after photobleaching (FRAP) analysis at the plasma membrane revealed equal mobilities for gp130-YFP and Jak1-YFP. Thus, Jak1-YFP diffuses like a transmembrane protein indicating that membrane-bound Jak1 does not exchange rapidly with cytosolic Jaks. Applying a novel dual-color FRAP approach we found that immobilization of gp130-CFP by a pair of monoclonal antibodies led to a corresponding immobilization of co-transfected Jak1-YFP. We conclude from these findings that Jak1, once bound to a gp130 molecule, does not exchange between different receptors at the plasma membrane neither via the cytoplasmic compartment nor via a membrane-associated state.
Efficient Modal Decomposition and Reconstruction of Riser Response due to VIV (2011)

Vortex-Induced-Vibrations (VIV) due to ocean currents can consume a sizable portion of the allotted fatigue life of marine risers. Vibration monitoring and concurrent estimation of fatigue damage due to VIV can significantly enhance the safe and reliable operation of risers. To this end, riser response can be characterized by using sensors (e.g. accelerometers and/or angular rate sensors) to measure the motion of the riser at a few locations. Fatigue damage can be predicted along the entire length of riser from measured data using the method of modal decomposition and reconstruction. In this method the structural response of interest, such as stress and fatigue damage, is expressed by modal superposition, where the modal weights are estimated using measured data and analytical modeshapes. However the accuracy of this method declines as the sensor density (number of sensors per unit riser length) decreases, especially when the riser vibrates in high-order modes and exhibits traveling wave behavior. In this paper, an efficient frequency-domain methodology allowing for accurate reconstruction of the riser response along the entire riser using a limited number of sensors is proposed. We first identify the excited VIV modes (natural frequency and modeshape) using principal vectors of the cross spectral density. Modal decomposition and reconstruction is performed separately for each VIV band surrounding each excited mode. This allows us to use several (as many as the number of sensors) participating modes in each band, and thus improve the accuracy. Since the stress distribution is sensitive to the chosen set of participating modes, we optimize over several candidate sets, selecting the set of modes that result in the lowest prediction error. In order to improve the reconstruction of complex modes, particularly traveling waves, the modeshapes can be augmented with additional basis vectors. The additional basis vectors are obtained by shifting the phase of the normal modes by 90 degrees at every wave number using the Hilbert transform. Though developed in the context of VIV, the method can be used to estimate fatigue damage due to vibrations regardless of the excitation mechanism. The methodology is demonstrated using the NDP (Norwegian Deepwater Program) test data on a 38 meter long slender riser, using data from eight accelerometers. Results show that the proposed algorithm can reconstruct stresses and fatigue damage accurately along the length of the riser in the presence of traveling wave behavior using relatively few sensors.
Homogeneous Catalysis in Supercritical Fluids (1995)

Supercritical fluids (SCFs), compounds heated and pressurized beyond the critical point, have many unusual properties. Homogeneous molecular catalysts, which have far greater control over selectivity than heterogeneous solid catalysts, are now being tested in SCFs, and early results show that high rates, improved selectivity, and elimination of masstransfer problems can be achieved. As industry moves away from toxic or environmentally damaging solvents, supercritical carbon dioxide may be an ideal replacement medium for nonpolar or weakly polar chemical processes. More than simply substitutes for nonpolar solvents, SCFs can radically change the observed chemistry. Supercritical carbon dioxide is also an excellent medium for its own fixation, as demonstrated by studies of its hydrogenation.
Stent-assisted coil embolization of ruptured wide-necked aneurysms in the acute period: incidence of and risk factors for periprocedural complications (2014)

The periprocedural complication rate during SAC was 19.4% among 72 patients. Because of the high complication rate, microsurgical clipping or endovascular treatment with another technique (multiple-microcatheter or balloon-assisted technique) may be a more appropriate option for first-line treatment than SAC, especially in patients requiring EVD.
Effect of Voltage Range and BiPO 4 Coating on the Electrochemical Properties of LiNi 0.8 Co 0.15 Al 0.05 O 2 (2018)

Abstract BiPO 4 ‐coated LiNi 0.8 Co 0.15 Al 0.05 O 2 (NCA) cathode material is prepared by a precipitation method. Scanning electron microscope and X‐ray diffraction results demonstrate that the morphology and structure of NCA are not affected by BiPO 4 layer. Transmission electron microscopy analysis indicates that the thickness of the layer is about 10 nm. Electrochemical properties of NCA and BiPO 4 ‐coated NCA are investigated in different voltage ranges. The results show that the wider the charge and discharge cut‐off voltage is, the larger the specific capacity is, with the initial discharge capacity of 325.0 mAh g −1 within the voltage of 1.5‐4.8 V. The most significant discovery is the charge platform at 2.3‐2.5 V and the discharge platform at around 1.7 V, which accounts for the high capacity properties of NCA. Furthermore, the existence of BiPO 4 coating helps to enhance the cycle performance of NCA.
Supplementary Figure Legends from Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
Supplementary Table 1 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression (2023)

&lt;p&gt;PDF file - 111K, Targeting sequences of siRNA and shRNA&lt;/p&gt;
Charting the human respiratory tract with airborne nanoparticles: evaluation of the Airspace Dimension Assessment technique (2018)

Airspace Dimension Assessment (AiDA) is a technique to assess lung morphology by measuring lung deposition of inhaled nanoparticles. Nanoparticles deposit in the lungs predominately by diffusion, and average diffusion distances, corresponding to effective airspace radii (<i>r</i><sub>AiDA</sub>), can be inferred from measurements of particle recovery after varied breath holds. Also, particle recovery after a 0-s breath hold (<i>R</i><sub>0</sub>) may hold information about the small conducting airways. This study investigates <i>r</i><sub>AiDA</sub> at different volumetric sample depths in the lungs of healthy subjects. Measurements were performed with 50-nm polystyrene nanospheres on 19 healthy subjects aged 17-67 yr. Volumetric sample depths ranged from 200 to 5,000 ml and breath-hold times from 5 to 20 s. At the examined volumetric sample depths, <i>r</i><sub>AiDA</sub> values ranged from ~200-600 μm, which correspond to dimensions of the bronchiolar and the gas-exchanging regions of the lungs. <i>R</i><sub>0</sub> decreased with volumetric sample depth and showed more intersubject variation than <i>r</i><sub>AiDA</sub>. Correlations were found between the AiDA parameters, anthropometry, and lung function tests, but not between <i>r</i><sub>AiDA</sub> and <i>R</i><sub>0</sub>. For repeated measurements on 3 subjects over an 18-mo period, <i>r</i><sub>AiDA</sub> varied on average within ± 7 μm (± 2.4%). The results indicate that AiDA has potential as an efficient new in vivo technique to assess individual lung properties. The information obtained by such measurements may be of value for lung diagnostics, especially for the distal lungs, which are challenging to examine directly by other means.<b>NEW & NOTEWORTHY</b> This is the first study to measure effective airspace radii (<i>r</i><sub>AiDA</sub>) at volumetric sample depths 200-5,000 ml in healthy subjects by Airspace Dimension Assessment (AiDA). Observed <i>r</i><sub>AiDA</sub> were 200-600 μm, which corresponds to airspaces for the bronchiolar and the gas-exchanging regions around airway generation 14-17. <i>r</i><sub>AiDA</sub> correlated with lung function tests and anthropometry. Measurements of <i>r</i><sub>AiDA</sub> on 3 subjects over 11-18 mo were within ± 7 μm.
Carbon tetrabromide carbon doping of molecular beam epitaxial (GaAs) films (1994)

GaAs films were doped with carbon up to a hole concentration of 1.3×1020 cm−3 using CBr4 vapor. The material quality of the heavily doped films was found to be better than that obtained using evaporated carbon. Improvements at the highest doping levels include better surface morphology, higher hole mobilities, significantly stronger photoluminescence, and near unity substitutional incorporation. Doping pulses created using CBr4 exhibited abrupt transitions. From the results it is suggested that the material quality of the films doped with evaporated carbon are degraded at high doping levels due to surface combination of reactive carbon species.
Inhibition of Phosphatidylethanolamine Biosynthesis in Baby Hamster Kidney-21 Cells Infected with Semliki Forest Virus (1975)

Semliki Forest virus inhibits phosphatidylethanolamine biosynthesis in baby hamster kidney-21 cells 6 h after infection. Viral infection reduced the incorporation of [1,2-14C]-ethanolamine into intact cells by approximately 50%. A similar reduction in the activity of the ethanolaminephosphotransferase (EC 2.7.8.1) was also observed. The apparent Km for CDPethanolamine was 60 muM for the microsomal enzymes from infected or mock-infected cells. In addition, exogenous diglyceride only stimulated by 1.5-fold the ethanolaminephosphotransferase from virus- or mock-infected cells, whereas the same diglyceride preparations stimulated the cholinephosphotransferase (EC 2.7.8.2) from baby hamster kidney cells by sixfold. Generation of endogenous diglyceride by pretreatment of the microsomes with phospholipase C (EC 3.1.4.3) stimulated the activity of the cholinephosphotransferase but not the ethanolaminephosphotranferase. Semliki Forest virus does not inhibit all microsomal enzymes, since the activities of NADH- K3Fe(CN)6 reductase and NADH dehydrogenase (EC 1.6.99.3) were not affected. The ethanolaminephosphotransferase from virus- and mock-infected cells showed similar profiles of activity as a function of temperature; this result and other studies suggest that that membranous environment of the ethanolaminephosphotransferase was not significantly modified by the virus.
Systematic HDL Design of a S-? Fractional-N Phase-Locked Loop for Wireless Applications (2008)

This paper presents a systematic HDL design of a Sigma-Delta fractional-N phase-locked loop based on behavioral modeling. The proposed design consists in describing the mixed behavior of this PLL architecture starting from the specifications of each building block. The HDL models of critical PLL blocks have been described in VHDL-AMS to predict the different specifications of the PLL. The effect of different noise sources has been efficiently introduced to study the PLL system performances. The obtained results are compared with transistor-level simulations to validate the effectiveness of the proposed models.
Flow cytometry, a new approach to detect anti-live trypomastigote antibodies and monitor the efficacy of specific treatment in human Chagas' disease (1995)

Sera from patients chronically infected with Trypanosoma cruzi display antibodies that bind to epitopes of living trypomastigotes, known as lytic antibodies (LA), and are detected by a complement-mediated lysis test. Conventional serology antibodies (CSA) are also present in sera from patients with chronic infections but, in contrast to LA, are unable to recognize viable trypomastigotes. The presence of LA has been used as an important element in the criterion of cure in human Chagas' disease. Using flow cytometry technology, we introduced a new and sensitive immunomethod for the detection of anti-live trypomastigote membrane-bound antibodies. On the basis of serological tests (LA and CSA detection) and parasitological assays such as hemoculture (HE), patients were classified into the following groups: chronically infected untreated patients (NT) and treated not-cured patients (TNC), with positive HE and both LA and CSA in their sera; "dissociated" HE-negative patients (DIS), in whom LA was not detected whereas CSA were present; a group of cured HE-negative patients (CUR), who were both LA and CSA negative; and, as control, a group of non-chagasic individuals (NC). Sera from these patients were assayed by incubation with live bloodstream trypomastigotes, which were subsequently exposed to fluorescein isothiocyanate-conjugated anti-human immunoglobulin G. The parasites were then fixed, run in the cytometer, and identified on basis of their size and granularity gain adjustments. On the basis of experience with the complement-mediated lysis test, a level of 20% of parasites being fluorescein isothiocyanate fluorescence positive was used as a cutoff between effective and ineffective treatments. With this criterion, our results indicated that sera from NT and TNC patients were antibody positive whereas all sera from DIS, CUR, and NC patients did not contain membrane-bound antibodies. This new approach is a tool to easily identify anti-live T. cruzi membrane-bound antibodies that can be used to monitor the efficacy of Chagas' disease treatment.
Net Clinical Benefit of Adding Clopidogrel to Aspirin Therapy in Patients With Atrial Fibrillation for Whom Vitamin K Antagonists Are Unsuitable (2011)

Bristol-Myers Squibb and sanofi-aventis.
PALANTIR demo: leveraging SecaaS model for managing threats in industrial environments (2022)

PALANTIR, an EU-funded Innovation Action project, delivers tailored and pervasive resource protection through the Security-as-a-Service paradigm. This demo presents the architecture and validates the prototype against three threat scenarios with botnet, data breach and tampering attacks.
Deblending Seismic Data by Directionality Penalties (2016)

Summary In conventional seismic surveys, there is a waiting time between sequentially fired shots. This time is determined such that the deepest reflection of interest is recorded before the following source is fired. In a survey with simultaneous or blended sources, the waiting time between the firing of shots is not dependent on the deepest reflection of interest, it is usually much shorter and/or can have random time delays. Thus, the wavefields due to independent sources are overlapped in the records. The blended data exhibit strong discontinuities in the source direction, in contrast to the coherency expected from seismic measurements. A strategy for deblending could then be to suppress these discontinuities. In this paper, we propose to do this by designing an energy functional that uses a combination of individual functionals that penalize deviations from local plane waves in the reconstructed (deblended) data, as well as a least squares term that penalizes discrepancies between the deblended and the measured data. In this way, we derive a set of coupled nonlinear partial differential equations that we use for the deblending procedure.
Applying New Biotechnologies to the Study of Occupational Cancer ? A Workshop Summary (2020)

As high-throughput technologies in genomics, transcriptomics, and proteomics evolve, questions arise about their use in the assessment of occupational cancers. To address these questions, the National Institute for Occupational Safety and Health, the National Cancer Institute, the National Institute of Environmental Health Sciences, and the American Chemistry Council sponsored a workshop 8-9 May 2002 in Washington, DC. The workshop brought together 80 international specialists whose objective was to identify the means for best exploiting new technologies to enhance methods for laboratory investigation, epidemiologic evaluation, risk assessment, and prevention of occupational cancer. The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk.
Supplementary File(s): Cadence Modulation in Walking and Running: Pacing Steps or Strides? (2020)

Supplementary File(s): Cadence Modulation in Walking and Running: Pacing Steps or Strides?
Organics on oxidic metal surfaces: a first-principles DFT study of PMDA and ODA fragments on the pristine and mildly oxidized surfaces of Cu(111) (2016)

Metal-organic hybrid materials are ubiquitous and a fundamental understanding of the hybrid-interface is key for the development of these hybrid material systems. In this work, using first-principles density-functional theory (including van der Waals (vdW) corrections), we study the fundamental physico-chemical properties of the molecular fragments of pyromellitic dianhydride oxydianiline (PMDA-ODA) on pristine Cu(111), as well as oxidic p4:O/Cu(111) in order to investigate the effect of mild oxidation of the metal substrate on PMDA-ODA adsorption. Firstly, we report the most favorable adsorption geometries amongst the various surface models and correlate the adsorption behavior with the electronic structure of the molecular fragments and the substrate layer. PMDA adsorbs weakly on both the clean and mildly oxidized copper surface via vdW forces while ODA adsorbs much stronger with a significant charge transfer between the substrates. Here, the oxidic layer is found to reduce the adsorption strength of both fragments and in particular, the ODA molecule interacts with the substrate via additional hydrogen bonding. Finally, our simulated scanning tunneling microscopy (STM) images suggest possible orientations of PMDA and ODA on clean and oxidic Cu surfaces to guide future experiments.