gebhart/patrepeval huggingface dataset:
Research and design of an efficient collaborative filtering predication algorithm (2004)

Currently collaborative filtering has been widespread used to solve the problem of information overload. However there still remain two major limitations, data sparsity and scalability. We explore a new collaborative filtering algorithm to solve the problem of data scalability and improve the predication accuracy. It uses a binary tree to store partitioned items. In the process of tree formation, a K-means clustering is used to partition data and create the neighbor of similar items, and then predication based on a smaller item database is performed. Since the preliminary clustering greatly reduces the search space, the search for similar neighbor items will be faster than for the entire database. In addition, the cluster that contains similar items is cohesive, thus it can produce a higher overall accuracy. The experimental results argue that our algorithm obviously outperforms current CF algorithms and it is feasible and efficient.
On the Behavior of the Pd/D System: Evidence for Tritium Production (1998)

Evidence for tritium production in the Pd/D system under cathodic polarization is presented. A comparison of the observed distribution and that calculated, based on the conservation of mass, leads to the conclusion that tritium is produced sporadically at an estimated rate of ~103 to 104 atom/s. The results of several runs are interpreted by employing the concept of an electrode/electrolyte interphase and the accepted kinetics of hydrogen evolution. Burstlike events followed by longer periods of inactivity yield poor reproducibility when distributions are averaged over the total time of electrolysis.
Inheritance of Resistance to Bacterial Blight in Rice Cultivar Cas 209 (1983)

The mode of inheritance of resistance in rice cultivar Cas 209 to bacterial strain PX086, a representative of race II of Xanthomonas campestris pv. oryzae in the Philippines, was studied. The analysis of F 1 , F 2 , and backcross populations from the crosses of Cas 209 with susceptible cultivars revealed than Cas 209 resistance was controlled by a single dominant gene. Tests for linkage relationships indicated that this newly identified dominant gene was linked with Xa-4) with a recombination value of 27.4%, but was independent of Xa-5. This new gene for bacterial blight resistance was designated Xa-10.
Decoding the role of fatty acids and their metabolites in lung fibrosis (2023)

Idiopathic pulmonary fibrosis (IPF) is a progressive and life‑threatening interstitial lung disease of familial or sporadic onset. The incidence and prevalence of IPF range from 0.09 to 1.3 and from 0.33 to 4.51 per 10 000 people, respectively. IPF has a poor prognosis, and death usually occurs within 2 to 5 years following the diagnosis due to secondary respiratory failure. Currently, there are 2 drugs available to treat IPF, pirfenidone and nintedanib. Both only slow the disease progression and, in addition, have unfavorable safety profiles. IPF bears the histology of usual interstitial pneumonia, which is characterized by bronchiolization of distal airspaces, honeycombing, fibroblastic foci, and abnormal epithelial hyperplasia. In the last years, alterations in metabolic pathways, in particular those associated with fatty acid (FA) metabolism have been linked with the pathogenesis of lung fibrosis. Changes in FA profiles have been reported in lung tissue, plasma, and bronchoalveolar lavage fluid of IPF patients, and have been found to correlate with the disease progression and outcome. In addition, they have been associated with the development of a profibrotic phenotype of epithelial cells, macrophages, and fibroblasts / myofibroblasts contributing to their (trans)differentiation and production of the disease‑relevant mediators. Furthermore, strategies focusing on the correction of FA profiles in experimental models of lung fibrosis brought advances in understanding tissue scarring processes and contributed to the transition of new molecules into clinical development. This review highlights the role of FAs and their metabolites in IPF and provides evidence for therapeutic potential of lipidome manipulations in the treatment of this disease.
Dynamic Resource Scheduling in Mobile Edge Cloud with Cloud Radio Access Network (2018)

Nowadays, by integrating the cloud radio access network (C-RAN) with the mobile edge cloud computing (MEC) technology, mobile service provider (MSP) can efficiently handle the increasing mobile traffic and enhance the capabilities of mobile devices. But the power consumption has become skyrocketing for MSP and it gravely affects the profit of MSP. Previous work often studied the power consumption in C-RAN and MEC separately while less work had considered the integration of C-RAN with MEC. In this paper, we present an unifying framework for the power-performance tradeoff of MSP by jointly scheduling network resources in C-RAN and computation resources in MEC to maximize the profit of MSP. To achieve this objective, we formulate the resource scheduling issue as a stochastic problem and design a new optimization framework by using an extended Lyapunov technique. Specially, because the standard Lyapunov technique critically assumes that job requests have fixed lengths and can be finished within each decision making interval, it is not suitable for the dynamic situation where the mobile job requests have variable lengths. To solve this problem, we extend the standard Lyapunov technique and design the VariedLen algorithm to make online decisions in consecutive time for job requests with variable lengths. Our proposed algorithm can reach time average profit that is close to the optimum with a diminishing gap (1/V) for the MSP while still maintaining strong system stability and low congestion. With extensive simulations based on a real world trace, we demonstrate the efficacy and optimality of our proposed algorithm.
Functional Peptide Monolayers at Interfaces (2015)

Abstract Amphiphilic peptides can be designed to form ordered supramolecular structures at hydrophilic‐hydrophobic interfaces. These systems rely on the ability of peptides to fold into certain secondary structures at interfaces. This review focuses on the design of amphiphilic β‐sheet peptide assemblies in monolayers at interfaces, and their relevance to inducing mineralization and interactions with specific ions. In addition, the review discusses recent studies demonstrating the applicability of designed amphiphilic β‐sheet peptides to detection of specific small molecules and to elucidating intermolecular interactions relevant to drug delivery and enzyme catalysis systems.
The Inflammatory Reaction During Venous Hypertension in the Rat (2000)

These results suggested that microvascular occlusion in venules with elevation of the micropressure followed by reperfusion is a highly cytotoxic process in the rat mesentery which can be attenuated by MPFF pretreatment.
Nickel contacts for low cost solar cells (1980)

It is noted that nickel metallization of silicon solar cells offers a relatively inexpensive method of making electrical contact with the surface of the cell. More expensive methods, involving precious metals and costly processes, are widely used; these have been developed for space applications, where considerations of reliability predominate over those of cost. Since recent interest in terrestrial applications of solar cells has led to an increased concern over cost, nickel has assumed a position as a major candidate for solar cell metallization. It is shown that sintering can improve the integrity of the nickel-silicon bond. Evidence that the nickel-silicon contact can survive moderate environmental stress is presented.
Level crossing rates and MIMO capacity fades: impacts of spatial/temporal channel correlation (2004)

It is well known that MIMO systems offer the promise of achieving very high spectrum efficiencies (many tens of bits/Hz) in a mobile environment. The gains in MIMO capacity are sensitive to the presence of spatial and temporal correlation introduced by the radio environment. In this paper we examine how MIMO capacity is influenced by a number of factors, e.g.: a) temporal correlation, b) various combinations of low/high spatial correlations at either end, c) combined spatial and temporal correlations, In all cases we compare the channel capacity that would be achievable under independent fading. We investigate the behaviour of "capacity fades", examine how often the capacity experiences the fades, develop a method to determine level crossing rates and average data durations and relate these to antenna numbers.
Large-Dose Oral Dextromethorphan as an Adjunct to Patient-Controlled Analgesia with Morphine after Knee Surgery (2001)

Dextromethorphan is a weak N-methyl-d-aspartate (NMDA) receptor antagonist that inhibits spinal cord sensitization in animal models of pain and also inhibits the development of cutaneous secondary hyperalgesia after tissue trauma. Perhaps coadministration of an NMDA antagonist with an opioid would lead to better pain relief, particularly with movement and an opioid-sparing effect. This has been shown for ketamine, but previous studies with dextromethorphan that have used small doses have shown only a modest reduction in morphine requirements with no or minimal changes in the postoperative pain experience. We sought to determine whether a large dose of this drug, just below the maximum tolerated dose, could potentiate morphine analgesia while simultaneously causing a significant improvement in the management of the postoperative pain experience. Sixty-six patients undergoing knee surgery were enrolled in the study. The study design was a prospective, randomized double-blinded comparison with placebo of 200 mg of dextromethorphan given eight hourly. Postoperative pain experiences were assessed by postoperative morphine usage. Visual analog and verbal rating scales were used to assess pain with movement as well as side effects. Dextromethorphan treatment led to a significant but modest reduction in morphine requirements (29.3% P < 0.05) but no reduction in postoperative pain levels. We conclude that increasing orally administered dextromethorphan to near maximum tolerated doses does not provide greater morphine sparing than 20-40 mg given 6-8 hourly as in previous studies. Furthermore we conclude that dextromethorphan does not improve pain scores in a manner expected of a drug with NMDA antagonist properties.
Building mixture trees from binary sequence data (2006)

We develop a new method for building a hierarchical tree from binary sequence data. It is based on an ancestral mixture model. The sieve parameter in the model plays the role of time in the evolutionary tree of the sequences. By varying the sieve parameter, one can create a hierarchical tree that estimates the population structure at each fixed backward point in time. Application to the clustering of the mitochondrial DNA sequences of Griffiths & Tavare (1994) shows that the approach performs well. Theoretical and computational properties of the ancestral mixture model are further developed. Copyright 2006, Oxford University Press.
Breath‐hold Three‐dimensional Lung Perfusion Imaging and Pulmonary Angiography after Contrast Administration1 (2001)

Summary We introduce a new combined approach using contrast‐enhanced magnetic resonance imaging (MRI) that may lead to a better sensitivity and specificity in staging pulmonary embolism (PE). A short protocol involving the application of two breath‐hold three‐dimensional (3D) pulse sequences and contrast agent injection is proposed and assessed on 35 patients following a consensus for anticoagulant therapy treatment under the suspected presence of PE. The protocol considers first the application of a 3D lung perfusion scan (MRPP) with high temporal and moderate spatial resolution to obtain volumetric parenchymal perfusion/ enhancemerit patterns to help localise segmental and sub‐segmental perfusion defects. Secondly, a high resolution 3D pulmonary MRA scan (MRPA) is performed to visualise the entire thoracic vasculature and to permit the inspection of each vessel separately. Multiplanar reformation of the MRPP data made it possible to evaluate the extent of any perfusion defect in all planes. Although a wide range of diffuse perfusion defects on MRPP were observed, PE could be ruled out after a careful inspection of the MRPA data. Perfusion abnormalities with a clear wedge appearance predicted the appearance of PE on MRPA subsequently confirmed with conventional pulmonary arteriography. We feel that this combined protocol provides a better insight to the localisation of PE than the MRPA alone and may play an important role in the assessment of patients with respiratory complications.
Fluid Structure Interaction for Bird Impact Problem: Experimental and Numerical Investigation (2012)

International audience
VIV Responses of Riser With Buoyancy Elements: Forced Motion Test and Numerical Prediction (2017)

Steel Lazy Wave Riser (SLWR) is an attractive deep water riser concept. When subjected to vortex induced vibrations (VIV), the vortex shedding process of the buoyancy element and the bare riser section will be different due to the difference in diameter. VIV responses can be strongly influenced by the dimension of the buoyancy element and its arrangement. Empirical VIV prediction programs, such as VIVANA, SHEAR7 and VIVA, are widely used by the industry for design against VIV loads. However, there is lack of hydrodynamic data to be used in these programs when buoyancy elements are present. Experiment to obtain hydrodynamic data for riser with staggered buoyancy elements was carried out in the towing tank in SINTEF Ocean. A rigid cylinder section with three staggered buoyancy elements was subjected to harmonic forced cross-flow (CF) motions. Hydrodynamic forces on one of the buoyancy elements were directly measured in addition to the measured forces at both ends of the test section. Two buoyancy element configurations were tested and the corresponding hydrodynamic data are compared with that of a bare cylinder. The obtained hydrodynamic data was also used in VIV prediction software and good prediction against existing flexible cylinder staggered buoyancy element VIV test data was achieved. A roadmap to achieve an optimal SLWR design by combining different experimental and numerical methods is suggested.
TK-C30 fuel transfer complex for spent fuel assemblies (1987)

The Freiberg Fuel Institute has developed a fuel transfer complex of the TK-C30 type designed for transfer and/or shipping of WWER-440 spent fuel assemblies. The transfer complex is described together with its specifications and essential features.
Studies on Complete Treatment of Pulp Waste Liquor and Utilization of By-products (1968)

On the assumption that complete utilization of pulp waste liquor is the best method for its disposal, a number of methods known thus far were reviewed.The first problem under study was evaporation and combustion of the pulp waster liquor and recovery of cooking chemicals. In search for a new method as simple as possible to recover chemicals of the lowest quality available for reuse for the cooking of pulp, several discoveries were made.1. The KP black liquor was first baked and then burned in the oxidizing atmosphere. The resultanta shes (I) contained 80.7% of Na2CO3 and 17.1% of Na2SO4, but neither Na2S2O3 nor Na2S. The ashes (II) obtained in a similar manner from the NSSC black liquor contained 59.6% of Na2CO3 and 32.3% of Na2SO4.2. The NSSC cooking liquor and Na base acid sulfite pulp cooking liquor were prepared by sulfitation of (I).3. Carbonization of an aqueous solution of (II) in an ammoniacal medium converted both Na2SO4 and Na2CO3 to NaHCO3 and the latter was recovered from the mother liquor containing (NH4)2SO4.4. The NSSC black liquor was subjected to evaporation and combustion to yield an aerosol containing Na. Air oxidation of this aerosol together with SO2 gave anhydrous sodium sulfate powders (95-98% Na2SO4).The above mentioned findings will, when commercialized, not only make an important contribution to the pulp industry but also exercise a great influence upon other industries. For example, an alkali which is used for decomposing the pulp waste liquor for further utilization will be recovered really.Morover, fixation of sulfur which is present in petroleumderived fuel as Na2SO4 or (NH4)2SO4 will become possible, and a solution to the problems of waste gas containing SO2 is expected to be worked out.
Study of Zn‐Cu Ferrite Nanoparticles for LPG Sensing (2013)

Nanostructured zinc-copper mixed ferrite was synthesized using sol-gel method. XRD patterns of different compositions of zinc-copper ferrite, Zn(1-x)Cu(x)Fe2O4 (x = 0.0, 0.25, 0.50, 0.75), revealed single phase inverse spinel ferrite in all the samples synthesized. With increasing copper concentration, the crystallite size was found to be increased from 28 nm to 47 nm. The surface morphology of all the samples studied by the Scanning Electron Microscopy there exhibits porous structure of particles throughout the samples. The pellets of the samples are prepared for LPG sensing characteristics. The sensing is carried out at different operating temperatures (200, 225, and 250°C) with the variation of LPG concentrations (0.2, 0.4, and 0.6 vol%). The maximum sensitivity of 55.33% is observed at 250°C operating for the 0.6 vol% LPG.
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C (2021)

Subcortical white matter (WM) stroke accounts for 25% of all strokes and is the second leading cause of dementia. Despite such clinical importance, we still do not have an effective treatment for ischemic WM stroke, and the mechanisms of WM postischemic neuroprotection remain elusive. 3K3A-activated protein C (APC) is a signaling-selective analogue of endogenous blood protease APC that is currently in development as a neuroprotectant for ischemic stroke patients. Here, we show that 3K3A-APC protects WM tracts and oligodendrocytes from ischemic injury in the corpus callosum in middle-aged mice by activating protease-activated receptor 1 (PAR1) and PAR3. We show that PAR1 and PAR3 were also required for 3K3A-APC's suppression of post-WM stroke microglia and astrocyte responses and overall improvement in neuropathologic and functional outcomes. Our data provide new insights into the neuroprotective APC pathway in the WM and illustrate 3K3A-APC's potential for treating WM stroke in humans, possibly including multiple WM strokes that result in vascular dementia.
Ultra-low-loss optical fiber enabling purely passive 10 Gb/s PON systems with 100 km length (2009)

We demonstrate time division multiplexing (TDM) and wavelength division multiplexing/TDM (WDM/TDM) long reach 10 Gb/s passive optical network (PON) architectures of 100 km reach with no infield amplification or dispersion compensation. The purely passive nature of the 100 km systems is enabled by the use of ultra-low-loss optical fiber with average attenuation of 0.17 dB/km and downstream transmission with a 10 Gb/s signal modulated with the duobinary format. The high tolerance of duobinary to dispersion, stimulated Brillouin scattering (SBS), and self-phase modulation (SPM) are all key factors to achieving good system performance at this distance, as is the significantly reduced loss from the ultra-low-loss fiber. We show that this combination of fiber and downstream signal format allow split ratios up to 1:128 for both system architectures. The achievable split ratio is reduced for standard single-mode fiber and/or use of an NRZ modulated downstream signal. Standard strength forward error correction (FEC) is used for the WDM/TDM system but is not required for the TDM system.
Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 (2005)

During angiogenic remodeling, Ang-1, the ligand of Tie2 tyrosine kinase, is involved in vessel sprouting and stabilization through unclear effects on nascent capillaries and mural cells. In our study, we hypothesized that the Ang-1/Tie2 system could cross-talk with integrins, and be influenced by the dynamic interactions between extracellular matrix and endothelial cells (ECs). Here, we show that alpha5beta1 specifically sensitizes and modulates Tie2 receptor activation and signaling, allowing EC survival at low concentrations of Ang-1 and inducing persistent EC motility. Tie2 and alpha5beta1 interact constitutively; alpha5beta1 binding to fibronectin increases this association, whereas Ang-1 stimulation recruits p85 and FAK to this complex. Furthermore, we demonstrate that Ang-1 is able to mediate selectively alpha5beta1 outside-in FAK phosphorylation. Thus, Ang-1 triggers signaling pathways through Tie2 and alpha5beta1 receptors that could cross-talk when Tie2/alpha5beta1 interaction occurs in ECs plated on fibronectin. By using blocking antibodies, we consistently found that alpha5beta1, but not alphavbeta3 activation, is essential to Ang-1-dependent angiogenesis in vivo.
Development of a diagnostic PCR assay that targets a heat-shock protein gene (groES) for detection of Pseudomonas spp. in cystic fibrosis patients (2003)

Laboratory detection of Pseudomonas spp., in particular Pseudomonas aeruginosa, remains an important assay in the management of patients with cystic fibrosis (CF). As the groES and groEL genes of P. aeruginosa have now been cloned and their nucleotide sequences determined, the aim of this study was to develop a novel PCR assay for the detection of Pseudomonas spp. from patients with CF by employing conserved primer regions of the groE heat-shock protein domain gene. A PCR assay was designed that targeted a 536 bp region of the groE gene to detect Pseudomonas spp. PCR amplification of genomic DNA from extracted organisms generated an amplicon of the expected size (approx. 536 bp) for all P. aeruginosa (n = 60), Pseudomonas putida, Pseudomonas fluorescens and Pseudomonas stutzeri isolates examined, but did not produce a positive amplicon for several other genera and species that are commonly isolated from the sputum of CF patients. RFLP analysis of the amplicons of all P. aeruginosa isolates demonstrated a single RFLP type that consisted of three bands at approximately 80, 190 and 250 bp; direct sequencing of the amplicons demonstrated the presence of a single sequence type, indicating the highly conserved nature of this region. In addition, the assay successfully produced a positive signal from primary non-selective plates of three known P. aeruginosa culture-positive CF patients, but was unable to generate a signal in a further six CF patients who had no history of infection with P. aeruginosa or other Pseudomonas spp. This assay is recommended to detect the presence of Pseudomonas spp., including P. aeruginosa, from primary culture plates that originate from laboratory analysis of CF patients' sputum, particularly at review, in those patients with no previous history of Pseudomonas infection or those who appear to be transiently colonized by this organism. Employment of such molecular methodologies, in conjunction with routine clinical sputum cultures, may provide improved information on the microbial status of CF patients, which will aid clinicians in both optimum patient management in terms of antibiotic regimes and CF centre infection-control practices.