gebhart/patrepeval huggingface dataset:
The wear of oriented UHMWPE under isotropically rough and scratched counterface test conditions. (2001)

Unidirectional wear tests of UHMWPE against smooth counterfaces show that molecular chains at the surface of virgin material become oriented parallel to the sliding direction giving low wear rate. It is postulated that under more abrasive conditions and predominantly unidirectional motion as in knee prostheses, it may proof beneficial to provide molecular orientation of the bulk material. Therefore strips of UHMWPE were oriented by die drawing at elevated temperature and the resulting anisotropic material subjected to tensile tests, small punch tests and also unidirectional wear tests both parallel and perpendicular to the draw direction. The tensile tests showed that, in the parallel direction, the oriented UHMWPE became stiffer and less ductile compared to the virgin UHMWPE. In the perpendicular direction, there were reductions in yield stress, 5% proof stress and energy to failure compared to the virgin material. The small punch test showed that the oriented UHMWPE exhibited apparent hardening when tested in both parallel and perpendicular directions but the mechanical behaviour in the perpendicular direction was comparable to the virgin UHMWPE. The wear tests demonstrated that the oriented UHMWPE did not show any significant improvement of wear resistance for sliding against either isotropically rough or scratched counterfaces. There was no clear dependency between the mechanical properties and wear factors of the oriented UHMWPE.
A Must for Plant Tissue Culture Plant Tissue Culture: Methods and Applications in Agriculture Treavor A. Thorpe (1982)

Journal Article A Must for Plant Tissue Culture Get access Plant Tissue Culture: Methods and Applications in Agriculture, edited by Thorpe Treavor A.. Academic Press, New York, 1981, 379 p., illus., $23.50 (81-1850). David F. Karnosky David F. Karnosky New York Botanical Garden, Cary Arboretum, Millbrook, NY 12545 Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 32, Issue 2, February 1982, Page 144, https://doi.org/10.2307/1308575 Published: 01 February 1982
A frequency-domain decision feedback equalizer for multipath echo cancellation (2002)

A block decision feedback equalizer (DFE) implemented in the frequency domain is derived. The new algorithm is directly applicable to multipath echo cancellation in digital transmission systems. The new equalizer consists of two distinct parts, namely a filtering part of low complexity implementable on a single VLSI chip, and an efficient filter updating part which can be implemented in today's technology DSPs. In both parts, block formulations in the frequency domain are developed, with different block sizes for each case. The resulting equalizer enjoys the computational advantages of frequency domain implementations (studied extensively for linear equalization schemes) offering at the same time the well-known superior performance of DFE.
Supplementary Table 3.4 from Alterations in Gemin5 Expression Contribute to Alternative mRNA Splicing Patterns and Tumor Cell Motility (2023)

Supplementary Table 3.4 from Alterations in Gemin5 Expression Contribute to Alternative mRNA Splicing Patterns and Tumor Cell Motility
From ferrocene to fluorine-containing penta-substituted derivatives and all points in-between; or, how to increase the available chemical space (2019)

In spite of the growing interest in fluorine-containing compounds, and the improvements in materials, optical and biological properties that can arise from substitution of a phenyl ring by ferrocene within a molecular scaffold, synthetic strategies that allow the efficient preparation of fluoroferrocene derivatives are scarce. Following conversion of ferrocene to fluoroferrocene, we have developed routes to fluorine-containing di-, tri-, tetra- and penta-substituted ferrocene derivatives to extend the available chemical space. Our approach is based on the identification of suitable reagents and conditions to achieve fluorine-directed deprotometalation, and exploitation of the halogen 'dance' rearrangement in the ferrocene series.
Investigation of Input Nonlinearity in Sequential Load Modulated Balanced Amplifiers (2022)

This paper investigates the impact of input nonlinearity in the sequential load modulated balanced amplifier (SLMBA) configuration. Theoretical analysis identifies that the utilization of Class-F- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> control amplifier (CA) can provide high and flat efficiency performance in low-power region and stable balanced amplifier (BA) load modulation in high-power region under second harmonic source <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(Z_{2S})$</tex> variation. The immunity to input nonlinearity of Class-F- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> operation provides CA flexible <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$Z_{2S}$</tex> design space in broadband SLMBA realization. Based on the load-pull experimental results, the optimum design space of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\angle\Gamma_{2S}$</tex> over (-90°, 90°) is chosen as the safe design region for Class-B/J BA and Class-F <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> CA. Following the investigation results, an identical input matching network (IMN) with tuned <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$Z_{2S}$</tex> terminations was designed for both CA and BA cells for an SLMBA operating from 1.8 to 2.6 GHz leaveraging high efficiency back-off performance from a Class-F- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> CA. Measured results showed high drain efficiency (DE) of 53.2% to 64.7% at 8-dB back-off and 62.7% to 67.4% at peak power as well.
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity (2006)

The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is found with high frequency in many human cancer cells, pharmacological inhibition of CDKs with small molecules has the potential to provide an effective strategy for the treatment of cancer. The 2,4-diamino-5-ketopyrimidines 6 reported here represent a novel class of potent and ATP-competitive inhibitors that selectively target the cyclin-dependent kinase family. This diaminopyrimidine core with a substituted 4-piperidine moiety on the C2-amino position and 2-methoxybenzoyl at the C5 position has been identified as the critical structure responsible for the CDK inhibitory activity. Further optimization has led to a good number of analogues that show potent inhibitory activities against CDK1, CDK2, and CDK4 but are inactive against a large panel of serine/threonine and tyrosine kinases (K(i) > 10 microM). As one of these representative analogues, compound 39 (R547) has the best CDK inhibitory activities (K(i) = 0.001, 0.003, and 0.001 microM for CDK1, CDK2, and CDK4, respectively) and excellent in vitro cellular potency, inhibiting the growth of various human tumor cell lines including an HCT116 cell line (IC(50) = 0.08 microM). An X-ray crystal structure of 39 bound to CDK2 has been determined in this study, revealing a binding mode that is consistent with our SAR. Compound 39 demonstrates significant in vivo efficacy in the HCT116 human colorectal tumor xenograft model in nude mice with up to 95% tumor growth inhibition. On the basis of its superior overall profile, 39 was chosen for further evaluation and has progressed into Phase I clinical trial for the treatment of cancer.
Temperature‐Dependent Properties of ( Bi 1/2 Na 1/2 ) TiO 3 –( Bi 1/2 K 1/2 ) TiO 3 – SrTiO 3 Lead‐Free Piezoceramics (2012)

Ferroelectric and piezoelectric properties of SrTiO 3 –modified (0, 3, and 5 mol%) 0.8 Bi 1/2 Na 1/2 TiO 3 –0.2 Bi 1/2 K 1/2 TiO 3 lead‐free piezoceramics were investigated as a model system in an attempt to lay a guideline for developing lead‐free piezoelectric materials with large strains. Two guidelines, one for the choice of base composition and the other for the choice of chemical modifiers, were assumed from our current understanding of the mechanism involved. Dielectric permittivity of both poled and unpoled samples was measured and compared, leading to a conclusion that the frequency‐independent anomaly ( T F‐R ) is the temperature at which induced‐ferroelectric order converts back to relaxor state. The correlation between T F‐R and depolarization temperature ( T d ) was shown by the comparison with T d determined by thermally stimulated depolarization current measurements, whereas the ferroelectric‐relaxor transition temperature T F‐R was determined using poled samples. A large unipolar strain of 0.36% ( S max / E max = 600 pm/V) at a driving field of 6 kV/mm was obtained at room temperature for a SrTiO 3 content of 5 mol%. Temperature‐dependent measurements of both polarization and strain from room temperature to 200°C revealed that the origin of the large strain is due to a reversible field‐induced ergodic relaxor‐to‐ferroelectric phase transformation.
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases (2020)

RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world's largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org.
Correction to: Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness (2022)

This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.
Sliding Mode Observer Design for a Parabolic PDE in the Presence of Unknown Inputs (2018)

Abstract This paper considers observer design for systems modeled by linear partial differential equations (PDEs) of parabolic type, which may be subject to unknown inputs. The system is assumed to have only one spatial dimension, over which it is discretised to obtain what is referred to as the lattice system, which is a set of linear time invariant (LTI) ordinary differential equations (ODEs) having a canonical Toeplitz‐like structure with a specific sparsity pattern. This lattice structure is shown to be particularly appropriate for step‐by‐step sliding mode observer design that can reconstruct the state estimates at the points of discretisation and estimate the unknown input. Simulation results for both stable and unstable PDEs show that accurate state estimates can be provided at the points of discretisation. An approach to reconstruct the unknown input is demonstrated.
Modulated photocurrent experiments-comparison of different data treatments (2014)

Modulated Photocurrent experiments provide a powerful tool to characterize localized defect states within the band gap of semiconductors. However, in recent years, different data analysis methods have been established. The method proposed by Herberholz et al. identify defect positions and attempt-to-escape frequencies considering the phase shift between excitation flux and measured photo current only. In contrast, Brüggemann et al. propose to use phase shift and amplitude of the modulated photo current to resolve an energy dependent density of trap states. This work compares both analysing procedures. We demonstrate that for simple and dominant defects, such as acceptor or donor like monovalent traps, both methods give equivalent results. However, the Herberholz method fails for more complex defect arrangements as exemplified on hydrogenated amorphous silicon or polycrystalline CuInSe2.
Changes in biosynthesis of exopolysaccharide in Lactococcus lactis subspecies cremoris treated by moderate pulsed electric field treatment (2017)

Metabolome analysis and physicochemical analyses were executed with cell extracts of a Lactococcus lactis subspecies cremoris strain treated by moderate pulsed electric field (PEF) to elucidate the mechanism of enhanced production of exopolysaccharide (EPS) by the treatment. Metabolome analysis by capillary electrophoresis time of flight mass spectrometry annotated 224 metabolites from the cytoplasmic extract of the strain, which, however, showed no significant changes in metabolites related to the EPS production. Electron microscopic observation and chemical analysis of undecaprenoids as carrier of EPS biosynthetic intermediates suggested that PEF treatment dissociated immature EPSs from the intermediates due to the focal electro-condensation of hydrogen ions at the cell surface. Thus, liberated undecaprenyl phosphates were recycled efficiently, which resulted in mass increase of EPS with smaller molecular weight. The study suggested the feasibility of moderate PEF treatment as a food processing technique and revealed the mechanism of enhanced production of EPS by the treatment.
ChemInform Abstract: 1,5‐DIMETHYLBICYCLO(3.3.0)OCTANE‐2,6‐DIONE AND 1,5‐DIMETHYLBICYCLO(3.3.0)OCTA‐3,7‐DIENE‐2,6‐DIONE. BASIC SYNTHONS FOR SUBSTITUTED SEMIBULLVALENES (1984)

Abstract Grundbausteine substituierter Semibullvalene.
Recording brain responses to TMS of primary motor cortex by EEG – utility of an optimized sham procedure (2021)

The results validate the effectiveness of our optimized sham approach. Despite the presence of typical responses attributable to sensory input, the procedure provided evidence for direct cortical activation by subthreshold TMS of M1. The findings are relevant for future TMS-EEG experiments that aim at measuring regional brain target engagement controlled by an optimized sham procedure.
Three-dimensional motion measurements using feature tracking (2008)

Feature tracking was developed to efficiently compute motion measurements from volumetric ultrasound images. Prior studies have demonstrated the motion magnitude accuracy and computation speed of feature tracking. However, the previous feature tracking implementations were limited by performance of their calculations in rectilinear coordinates. Also, the previous feature tracking approaches did not fully explore the three dimensional (3- D) nature of volumetric image analysis or utilize the 3-D directional information from the tracking calculations. This study presents an improved feature tracking method which achieves further computation speed gains by performing all calculations in the native spherical coordinates of the 3-D ultrasound image. The novel method utilizes a statistical analysis of tracked directions of motion to achieve better rejection of false tracking matches. Results from in vitro tracking of a speckle target show that the new feature tracking method is significantly faster than correlation search and can accurately determine target motion magnitude and 3-D direction.
Wave equation migration with the phase-shift method (1978)

Abstract Accurate methods for the solution of the migration of zero-offset seismic records have been developed. The numerical operations are defined in the frequency domain. The source and recorder positions are lowered by means of a phase shift, or a rotation of the phase angle of the Fourier coefficients. For applications with laterally invariant velocities, the equations governing the migration process are solved very accurately by the phase-shift method. The partial differential equations considered include the 15 degree equation, as well as higher order approximations to the exact migration process. The most accurate migration is accomplished by using the asymptotic equation, whose dispersion relation is the same as that of the full wave equation for downward propagating waves. These equations, however, do not account for the reflection and transmission effects, multiples, or evanescent waves. For comparable accuracy, the present approach to migration is expected to be computationally more efficient than finite-difference methods in general.
Polaronic structure of excess electrons and holes for a series of bulk iron oxides (2020)

With the use of a gap-optimized hybrid functional and large supercells, it is found that while the electron hole polaron generally localises onto a single iron site, the electron polaron localises across two iron sites of the same spin layer.
RehabVisual: Development of an Application to Stimulate Visuomotor Skills (2018)

The stimulation of visuomotor skills has a relevant role in the rehabilitation of children with neurological dysfunctions / pathologies.However, the methods of evaluation and intervention for children under the age of 18 months are few systematic and not directed to the problem of each one.For this reason it was important to develop a system that will fill this gap.Therefore, the main purpose of this paper is to present the development process of a tool called RehabVisual -evaluation and stimulation of visuomotor competences.RehabVisual has the objective to promote the evaluation and the stimulations of visuomotor skills in children between the ages of 0 and 18 months.The platform has two sessions: database that records all the clinical information of the child and protocol with stimuli according to the development of the child.This plataform it was realized with physicians and occupations therapists from the Service of Physical Medicine and Rehabilitation (PMR) of the Hospital D. Estefânica of the Hospital Center of Lisbon Central and it was approved by the Portuguese Ethics Committees of this Hospital.The RehabVisual can be used by physicians, occupational therapists, and caregivers and is characterized for being a tool user-friendly, versatile and adaptable to the needs of each child.
mRNA Abundance and Half-Life Measurements (2003)

The expression of many genes is regulated at multiple levels. For most genes, the predominant control is at transcription, and this is usually inferred from changes in mRNA levels that respond to specific stimuli. However, changes in mRNA stability may contribute to observed variation in mRNA abundance, and many such changes in mRNA stability probably remain undetected. The relative contributions of posttranscriptional regulatory circuits can only be detected by careful RNA analysis.
Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral ceil attachment protein σ1 (1984)

The complete sequence of the reovirus (serotype 3) S1 gene was obtained by using cloned cDNA derived from the RNA segment. This gene is 1416 nucleotides in length and contains two open reading frames. The first reading frame has a coding capacity of 455 amino acids, sufficient to account for the known S1 product, protein sigma 1 (42,000 MW). It possesses a signal peptide as well as three possible glycosylation sites. No homology could be detected when this gene sequence and the deduced amino acid sequence were compared to published sequences of the corresponding gene of a human rotavirus. The second reading frame (not in phase with the first) starts at the second ATG recently shown to be a functional initiation site. It has a coding capacity of 120 amino acids. Its outstanding feature is the highly basic amino-terminal region, a characteristic apparently shared by a number of DNA binding proteins. It is speculated that this protein, hitherto undetected, may play a role in mediating viral and/or host nucleic acid transcription.
Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: an experimental study in the rabbit (2014)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Data from Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;We studied the impact of mTOR signaling inhibition with rapamycin in head and neck squamous cell carcinoma (HNSCC) in the neoadjuvant setting. The goals were to evaluate the mTOR pathway as a therapeutic target for patients with advanced HNSCC, and the clinical safety, antitumor, and molecular activity of rapamycin administration on HNSCC.&lt;/p&gt;Patients and Methods:&lt;p&gt;Patients with untreated stage II–IVA HNSCC received rapamycin for 21 days (day 1, 15 mg; days 2–12, 5 mg) prior to definitive treatment with surgery or chemoradiation. Treatment responses were assessed clinically and radiographically with CT and FDG-PET. Pre- and posttreatment biopsies and blood were obtained for toxicity, immune monitoring, and IHC assessment of mTOR signaling, as well as exome sequencing.&lt;/p&gt;Results:&lt;p&gt;Sixteen patients (eight oral cavity, eight oropharyngeal) completed rapamycin and definitive treatment. Half of patients were p16 positive. One patient had a pathologic complete response and four (25%) patients met RECIST criteria for response (1 CR, 3 PR, 12 SD). Treatment was well tolerated with no grade 4 or unexpected toxicities. No significant immune suppression was observed. Downstream mTOR signaling was downregulated in tumor tissues as measured by phosphorylation of S6 (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), AKT (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), and 4EBP (&lt;i&gt;P&lt;/i&gt; = 0.0361), with a significant compensatory increase in phosphorylated ERK in most patients (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Ki67 was reduced in tumor biopsies in all patients (&lt;i&gt;P&lt;/i&gt; = 0.013).&lt;/p&gt;Conclusions:&lt;p&gt;Rapamycin treatment was well tolerated, reduced mTOR signaling and tumor growth, and resulted in significant clinical responses despite the brief treatment duration, thus supporting the potential role of mTOR inhibitors in treatment regimens for HNSCC.&lt;/p&gt;&lt;/div&gt;