MP72-04 MICROALBUMINURIA AS A PREDICTOR OF DELAYED RENAL FUNCTION AFTER DONOR NEPHRECTOMY (2014)

You have accessJournal of UrologyTransplantation & Vascular Surgery II1 Apr 2014MP72-04 MICROALBUMINURIA AS A PREDICTOR OF DELAYED RENAL FUNCTION AFTER DONOR NEPHRECTOMY Young Eun Yoon, Kwang Suk Lee, Kyung Hwa Choi, Kwang Hyun Kim, Kang Su Cho, Joong Shik Lee, Won Sik Ham, Koon Ho Rha, Young Deuk Choi, Seung Choul Yang, and Woong Kyu Han Young Eun YoonYoung Eun Yoon More articles by this author , Kwang Suk LeeKwang Suk Lee More articles by this author , Kyung Hwa ChoiKyung Hwa Choi More articles by this author , Kwang Hyun KimKwang Hyun Kim More articles by this author , Kang Su ChoKang Su Cho More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Won Sik HamWon Sik Ham More articles by this author , Koon Ho RhaKoon Ho Rha More articles by this author , Young Deuk ChoiYoung Deuk Choi More articles by this author , Seung Choul YangSeung Choul Yang More articles by this author , and Woong Kyu HanWoong Kyu Han More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2243AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Kidney donation results in small increase in urinary protein because of compensatory hyperfiltration of contralateral remnant kidney. This study was conducted to determine the clinical implication of the urinary microalbumin/creatinine ratio (UACR) and the relationship between UACR and renal function after living donor nephrectomy. METHODS Between October 2009 and January 2013, 349 patients in our hospital underwent live donor nephrectomy. Among them, we excluded 160 patients who did not want to participate in this prospective study and did not visit our clinic 6 months postoperatively. Serum creatinine and cystatin C were measured prospectively to estimate the renal function. We divided normal (n=124) versus chronic kidney disease subjects (MDRD eGFR < 60mL/min/1.73m2 at 6 months postoperatively, n=65) to compare UACR at preoperation, immediate postoperation, 1st, 3rd, and 6th postoperative month. RESULTS During follow up period, the normal group constantly showed higher MDRD and cystatin C eGFR than CKD group. When we compared UACR between two groups, there were no differences preoperatively and immediate postoperatively (4.18 vs 5.02, 20.81 vs 20.06 mg/mmol, respectively). However, UACR at 1 month after nephrectomy was higher in CKD group (8.57 vs 15.21 mg/mmol, p=0.008). Although UACR of CKD group showed higher tendency at postoperative months 3 and 6, there were no statistical significance. As a continuous variable, UACR at postoperative 1 month was associated with new onset of CKD (odds ratio: 1.07 for each 0.1mg/mmol increase; p=0.003). When we generate an ROC curve for CKD prediction with MDRD eGFR, cystatin C eGFR and UACR at postoperative 1 month, the predictive probability was very powerful (AUC = 0.875, P<0.001). CONCLUSIONS The higher UACR in the CKD group at 1 month after surgery indicates their recovery of renal function is still ongoing while that of the normal group has already finished. And we should observe donors who showed higher UACR at postoperative 1 month closely. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e824 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Young Eun Yoon More articles by this author Kwang Suk Lee More articles by this author Kyung Hwa Choi More articles by this author Kwang Hyun Kim More articles by this author Kang Su Cho More articles by this author Joong Shik Lee More articles by this author Won Sik Ham More articles by this author Koon Ho Rha More articles by this author Young Deuk Choi More articles by this author Seung Choul Yang More articles by this author Woong Kyu Han More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...