gebhart/patrepeval huggingface dataset:
Electrochemical Oxidation of Hexafluoropropylene Oxide Dimer Acid (GenX): Mechanistic Insights and Efficient Treatment Train with Nanofiltration (2019)

Hexafluoropropylene oxide dimer acid (HFPO-DA, trade name GenX) is a perfluoroalkyl ether carboxylic acid (PFECA) that has been detected in watersheds around the world. Similar to other per- and polyfluoroalkyl substances (PFASs), few processes are able to break HFPO-DA's persistent carbon-fluorine bonds. This study provides both experimental and computational lines of evidence for HFPO-DA mineralization during electrochemical oxidation at a boron-doped diamond anode with a low potential for the generation of stable organofluorine intermediates. Our density functional theory calculations consider the major operative mechanism, direct electron transfer, throughout the entire pathway. Initial oxidative attack does not break the ether bond, but leads to stepwise mineralization of the acidic side chain. Our mechanistic investigations reveal that hydroxyl radicals are unreactive toward HFPO-DA, while electrochemically activated sulfate facilitates its oxidation. Furthermore, we demonstrate that an NF90 membrane is capable of removing 99.5% of HFPO-DA from contaminated water. Electrochemical treatment of the nanofiltration rejectate is shown to reduce both energy and electrode costs by more than 1 order of magnitude compared to direct electrochemical treatment of the raw water. Overall, a nanofiltration-electrochemical oxidation treatment train is a sustainable destructive approach for the cost-effective elimination of HFPO-DA and other PFASs from contaminated water.
NEW INITIATIVES IN CAR PARK MANAGEMENT. PART 2: SECURITY (1998)

This article presents the results of interviews with British car park owners and operators to discover what new initiatives are being developed and introduced to the security and access control aspects of car park management. Car parks in Newcastle use the British Telecom (BT) optic cable network for audio and video signals to give customers the facility to make inquiries to the control room and see the person with whom they are speaking. Newcastle also has number plate scanning equipment. Access control provides improved security at facilities such as hospitals, where the coming and going of vehicles is irregular and liable to abuse. Closed circuit television (CCTV) plays an important part in car parks in Coventry city centre. A Stored Value card has been introduced at Leeds to improve security. Improved services sometimes bring more customers, but also increase the risks for car park operators and lead to higher insurance premiums. Advertising, cleaning services, and security are the obvious areas that operators are investigating, in an attempt to improve services and earn more income. Bold Lane MSCP in Derby is not only Britain's most secure car park, but could become the first to accept liability for the security of its visitors. Access is by bar-coded entry tickets, and every parking bay has a number.
Integral equation methods for electrostatics, acoustics and\n electromagnetics in smoothly varying, anisotropic media (2018)

We present a collection of well-conditioned integral equation methods for the\nsolution of electrostatic, acoustic or electromagnetic scattering problems\ninvolving anisotropic, inhomogeneous media. In the electromagnetic case, our\napproach involves a minor modification of a classical formulation. In the\nelectrostatic or acoustic setting, we introduce a new vector partial\ndifferential equation, from which the desired solution is easily obtained. It\nis the vector equation for which we derive a well-conditioned integral\nequation. In addition to providing a unified framework for these solvers, we\nillustrate their performance using iterative solution methods coupled with the\nFFT-based technique of [1] to discretize and apply the relevant integral\noperators.\n
Low Molecular Weight Polyethylenimine-graft-Tween 85 for Effective Gene Delivery: Synthesis and in Vitro Characteristics (2011)

The development of safe and efficient gene delivery systems is still a challenge for successful gene therapy. In this work, low molecular weight polyethylenimine (PEI 2K) was modified by Tween 85, which bears three oleate chains. Tween 85 modified PEI 2K (TP) could condense DNA efficiently, and TP/DNA complexes (TPCs) showed high resistance to salt-induced aggregation and enzymatic degradation. In addition, TP did not show the obvious cytotoxicity. The introduction of Tween 85 led to a significant increase in the cellular uptake of complexes with higher transfection efficiency, which was strongly inhibited by the addition of free Tween 85 in MCF-7/ADR cells, but not in MCF-7 cells. These results indicated that TP could be a potentially safe and effective copolymer for gene delivery, and TPCs could be taken up mainly by Tween 85-mediated endocytosis in MCF-7/ADR cells.
Abstract 371: Using Defibrillator Bioimpedance Waveforms to Measure Ventilation During Continuous Chest Compression CPR (2020)

Introduction: For patients with out of hospital cardiac arrest, prompt return of circulation and ventilation is vitally important for survival. Techniques and devices have been developed to ensure emergency responders are providing high quality chest compression, but there has been little progress in the area of ventilation. Until an advanced airway is placed, there has been no practical way to measure ventilation. The aim of this study is to develop a method to measure ventilation during continuous chest compressions cardiopulmonary resuscitation (CPR) that can be used to monitor and improve quality of ventilation during out of hospital CPR. Hypothesis: Defibrillator transthoracic bioimpedance can be used to identify ventilation waveforms prior to placement of an advanced airway during continuous chest compressions CPR. Methods: We examined 391 patients’ defibrillator files from four Resuscitation Outcomes Consortium sites for the presence of waveforms that met previously developed criteria and were manually annotated. Criteria for an acceptable ventilation waveform were: waveform amplitude ≥0.5 Ohm and waveform duration ≥1 sec. We recorded the number of ventilations, return of spontaneous circulation, initial heart rhythm, and ventilation rates. Following annotation, 333 of the 391 patients’ files had the necessary intubation time recorded and an automated program precisely measured the amplitude and duration of each ventilation. We determined mean (±SD) waveform amplitude and duration of inflation and deflation pre and post airway placement. Significance was determined using Wilcoxon ranked sum test. Results: Comparing the pre and post airway measurements did not result in any significant differences, except in duration of inflation, which was 1.06 ± 0.41 sec and 1.11 ± 0.52 sec, respectively, (p &lt;0.001). Ventilation waveforms had significantly lower amplitude and shorter duration during chest compressions than during pauses in compressions. Conclusion: Defibrillator transthoracic bioimpedance can be used to identify and monitor ventilations during continuous chest compressions CPR. Ventilation waveforms have lower amplitudes and shorter durations during chest compressions than during pauses in compressions.
Liquid‐phase sintering of highly Na + ion conducting Na 3 Zr 2 Si 2 PO 12 ceramics using Na 3 BO 3 additive (2017)

Abstract Na 3 Zr 2 Si 2 PO 12 ( NASICON ) is a promising material as a solid electrolyte for all‐solid‐state sodium batteries. Nevertheless, one challenge for the application of NASICON in batteries is their high sintering temperature above 1200°C, which can lead to volatilization of light elements and undesirable side reactions with electrode materials at such high temperatures. In this study, liquid‐phase sintering of NASICON with a Na 3 BO 3 ( NBO ) additive was performed for the first time to lower the NASICON sintering temperature. A dense NASICON ‐based ceramic was successfully obtained by sintering at 900°C with 4.8 wt% NBO . This liquid‐phase sintered NASICON ceramic exhibited high total conductivity of ~1 × 10 −3 S cm −1 at room temperature and low conduction activation energy of 28 kJ mol −1 . Since the room‐temperature conductivity is identical to that of conventional high‐temperature‐sintered NASICON , NBO was demonstrated as a good liquid‐phase sintering additive for NASICON solid electrolyte. In the NASICON with 4.8 wt% NBO ceramic, most of the NASICON grains directly bonded with each other and some submicron sodium borates segregated in particulate form without full penetration to NASICON grain boundaries. This characteristic composite microstructure contributed to the high conductivity of the liquid‐phase sintered NASICON .
An interacting multiple model approach to model-based prognostics (2004)

A system wide prognostic process is required to fulfill the needs of expensive and high availability industrial systems. The recent advances in model-based design technology have facilitated the integration of model-based diagnosis and prognosis of systems, leading to condition-based maintenance. In this paper an integrated prognostic process based on data collected from model-based simulations under nominal and degraded conditions is described. Interacting Multiple Model (IMM) is used to track the hidden damage. Remaining life prediction is performed by mixing mode-based life predictions via time-averaged mode probabilities. The prognostic process is demonstrated on a suspension system.
Special-Purpose Infrared Cells (1955)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. A. Friedel and M. G. Pelipetz, "Special-Purpose Infrared Cells," J. Opt. Soc. Am. 45, 892-892 (1955) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Quantification of antibiotic drug potency by a two-compartment radioassay of bacterial growth (1990)

The two-compartment radioassay for microbial kinetics based on continuous measurement of the 14CO2 released by bacterial metabolism of 14C-labeled substrate offers a valuable approach to testing the potency of antimicrobial drugs. By using a previously validated radioassay with gram-positive and gram-negative bacteria, a group of protein synthesis inhibitors was evaluated for their effect on microbial growth kinetics. All tested drugs induced changes in both the slopes and intercepts of the growth curves. An exponential growth model was applied to quantify the drug effect on the processes of bacterial 14CO2 liberation and cell generation. The response was measured in terms of a generation rate constant. A linear dependence of the generation rate constant on the dose of spectinomycin was observed with Escherichia coli. Sigmoidal-shaped curves were found in the assays of chloramphenicol and tetracycline. The implications of dose-response curves are discussed on the basis of the receptor site concept for drug action. The assay sensitivities for chloramphenicol and tetracycline were similar to those obtained by the cell counting method, but the sensitivity of the radioassay was at least 10 times greater for spectinomycin.
Abstract EP35: Longitudinal Lipidomic Profiling Of Left Ventricular Mass In American Indians: The Strong Heart Study (2022)

Background: Dyslipidemia is a major risk factor for CVD. Left ventricular mass (LVM) is an independent predictor of heart failure and other cardiovascular events. It is unclear whether and how altered plasma lipidome (all lipids in a plasma sample) affects LVM. The relationship between longitudinal change in plasma lipidome and change in LVM is also unstudied in any racial/ethnic group. Objective: To identify molecular lipid species associated with LVM, independent of traditional risk factors. Methods: Using an untargeted LC-MS, we repeatedly measured 1,542 lipids in 3,162 fasting plasma samples collected at two time points (2001-2003, 2006-2009, mean 5.5 years apart) from 1,581 American Indians in the Strong Heart Family Study. All participants were free of overt CVD at both time points. LVM was measured by M-mode echocardiography and LVM index (LVMI) was calculated as LVM/height 2.7 . Lipids associated with LVMI were identified by generalized estimating equation (GEE) models, adjusting for age, sex, center, BMI, smoking, blood pressure, renal function, LDL-c, and diabetes. We first conducted the analysis at each time point, separately, and then combined the results by meta-analysis. The longitudinal association between change in lipids and change in LVMI was examined by GEE, adjusting for the same covariates plus baseline lipids and LVMI. Multiple testing was controlled by false discovery rate at 0.05. Results: The mean age of participants was 39.8 years (62.5% women) at baseline and 45.1 years at follow-up. We identified 325 lipids (125 known), largely fatty acyls, sterol lipids, sphingolipids, glycerolipids, and glycerophospholipids, significantly associated with LVMI at both time points. Longitudinal changes in 17 lipids, including glycerolipids, glycerophospholipids, and sphingolipids, were either positively (ORs: 1.09 -1.95) or negatively (ORs: 0.50 - 0.69) associated with change in LVMI over 5 years of follow-up. Changes in lipids explain up to 1.58% of the variability in the change of LVMI during follow-up. Additional adjustments for use of anti-hypertensive and lipid-lowering drugs did not change the results. Conclusion: Altered fasting plasma lipidome and its longitudinal change over time were significantly associated with LVMI beyond clinical factors and baseline lipids. Our results shed light on the mechanisms through which dyslipidemia may affect LV remodeling, thereby contributing to heart failure or other cardiovascular events.
Cinnolines. VII. On the Reaction of 4-Cinnolinecarbonitrile with Ketone Carbanions (1974)

Reaction of 4-cinnolinecarbonitrile (I) with ketones was attempted in benzene, in the presence of sodium amide. In the case of a methyl ketones acetophenone (IIa) and acetone (IIc), the -CN group in 4-position of I was substituted to give 2-(4-cinnolinyl)-acetophenone (IIIa) and 1-(4-cinnolinyl)-2-propanone (IIIc), respectively. In the case of an ethyl ketone, propiophenone (IIb), the reaction product was not isolated, but 4-ethylcinnoline (IV) was obtained when reacted with diethyl ketone (IId). IV was considered to be formed secondarily from 2-(3-cinnolinyl)-3-pentanone (IIId). Reaction of I with methyl ethyl ketone (IIe) afforded two kinds of a product, 1-(4-cinnolinyl)-2-butanone (IIIe) and IV. In this case, also, 3-(4-cinnolinyl)-2-butanone (III'e), thought to be the precursor of IV, was not isolated.
Competitive strategies for faculty practice plans in the 1990s. (1994)

The upsurge in clinical revenue of faculty practice in academic centers over the last decade may be succumbing to RBRVS growth in managed care plans. Author Alan M. Zuckerman, FAAHC, investigates this possibility in his article.
MMP‐9 controls Schwann cell proliferation and phenotypic remodeling via IGF‐1 and ErbB receptor‐mediated activation of MEK/ERK pathway (2009)

Phenotypic remodeling of Schwann cells is required to ensure successful regeneration of damaged peripheral axons. After nerve damage, Schwann cells produce an over 100-fold increase in metalloproteinase-9 (MMP-9), and therapy with an MMP inhibitor increases the number of resident (but not infiltrating) cells in injured nerve. Here, we demonstrate that MMP-9 regulates proliferation and trophic signaling of Schwann cells. Using in vivo BrdU incorporation studies of axotomized sciatic nerves of MMP-9-/- mice, we found increased Schwann cell mitosis in regenerating (proximal) stump relative to wild-type mice. Treatment of cultured primary Schwann cells with recombinant MMP-9 suppressed their growth, mitogenic activity, and produced a dose-dependent, biphasic, and selective activation of ERK1/2, but not JNK and p38 MAPK. MMP-9 induced ERK1/2 signaling in both undifferentiated and differentiated (using dbcAMP) Schwann cells. Using inhibitors to MEK and trophic tyrosine kinase receptors, we established that MMP-9 regulates Ras/Raf/MEK-ERK pathways through IGF-1, ErbB, and PDGF receptors. We also report on the early changes of MMP-9 mRNA expression (within 24 h) after axotomy. These studies establish that MMP-9 controls critical trophic signal transduction pathways and phenotypic remodeling of Schwann cells.
V-band power amplifier MMICs exhibiting low power slump characteristics utilizing a production released 0.15-um GaAs PHEMT process (2009)

The design and performance of 0.15-um PHEMT V-band driver and power amplifier MMICs suitable for satellite communication systems is presented. The amplifiers utilize a proven commercially available production released process featuring demonstrated low power slump characteristics and reliability suitable for space applications. Experimental results for the driver amplifier MMIC demonstrate greater than 17 dB of small signal gain, 25 dBm saturated output power and 29% power added efficiency at 60 GHz. The power amplifier MMIC provides 17 dB of small signal gain, up to 27.5 dBm saturated output power and 26% power added efficiency. A 1200-hour test at 5 dB gain compression resulted in less than 0.5 dB of output power drift.
High‐Efficiency InP‐Based Photocathode for Hydrogen Production by Interface Energetics Design and Photon Management (2015)

The solar energy conversion efficiency of photoelectrochemical (PEC) devices is usually limited by poor interface energetics, limiting the onset potential, and light reflection losses. Here, a three‐pronged approach to obtain excellent performance of an InP‐based photoelectrode for water reduction is presented. First, a buried p–n + junction is fabricated, which shifts the valence band edge favorably with respect to the hydrogen redox potential. Photoelectron spectroscopy substantiates that the shift of the surface photovoltage is mainly determined by the buried junction. Second, a periodic array of InP nanopillars is created at the surface of the photoelectrode to substantially reduce the optical reflection losses. This device displays an unprecedented photocathodic power‐saved efficiency of 15.8% for single junction water reduction. Third, a thin TiO 2 protection layer significantly increases the stability of the InP‐based photoelectrode. Careful design of the interface energetics based on surface photovoltage spectroscopy allows obtaining a PEC cell with stable record performance in water reduction.
Ultrafiltration in an unstirred batch cell. Reply to comments (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleUltrafiltration in an unstirred batch cell. Reply to commentsDaniel R. Trettin and Mahendra R. DoshiCite this: Ind. Eng. Chem. Fundamen. 1982, 21, 2, 189Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://pubs.acs.org/doi/10.1021/i100006a018https://doi.org/10.1021/i100006a018research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Identification and characterization of a self-regulated repressor of translocation of the Tn3 element. (1979)

Gene fusions that bring expression of the lacZ gene under control of transcriptional and trnaslational signals within the transposable element Tn3 have been used to study regulation of Tn3-specified proteins. A gene encoding a 21,355-Mr peptide that represses translocation of Tn3 and acts at the level oquenced; amber, missense, and cis-dominant (operator-constitutive) point mutations in this gene have been isolated and characterized.
GRAPHITE: An Extensible Graph Traversal Framework for Relational Database Management Systems (2014)

Graph traversals are a basic but fundamental ingredient for a variety of graph algorithms and graph-oriented queries. To achieve the best possible query performance, they need to be implemented at the core of a database management system that aims at storing, manipulating, and querying graph data. Increasingly, modern business applications demand native graph query and processing capabilities for enterprise-critical operations on data stored in relational database management systems. In this paper we propose an extensible graph traversal framework (GRAPHITE) as a central graph processing component on a common storage engine inside a relational database management system. We study the influence of the graph topology on the execution time of graph traversals and derive two traversal algorithm implementations specialized for different graph topologies and traversal queries. We conduct extensive experiments on GRAPHITE for a large variety of real-world graph data sets and input configurations. Our experiments show that the proposed traversal algorithms differ by up to two orders of magnitude for different input configurations and therefore demonstrate the need for a versatile framework to efficiently process graph traversals on a wide range of different graph topologies and types of queries. Finally, we highlight that the query performance of our traversal implementations is competitive with those of two native graph database management systems.
Symbol synchronization using baud-rate sampling and data-sequence-dependent signal processing (1991)

An algorithm for symbol timing recovery using baud-rate sampling is presented. Using this algorithm, the decoded data sequence is scanned for particular data patterns that yield samples which need only to be added or subtracted to give an estimate of the required timing function. The statistics of occurrence of these data patterns are calculated for random binary data. The variance of the timing function estimates is calculated for pulses with raised-cosine spectra that have been degraded by quadratic delay distortion and is shown to be lower, in most cases, than for other synchronizers using baud-rate sampling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Th17 Cells in Cancer: The Ultimate Identity Crisis (2014)

T helper 17 (Th17) cells play a complex and controversial role in tumor immunity and have been found to exhibit a fluctuating identity within the context of cancer. The recent, expanding literature on these cells attests to their puzzling nature, either promoting or suppressing tumor growth depending on the malignancy and course of therapeutic intervention investigated. This review addresses several newly appreciated factors that may help delineate Th17 cells' immunological properties in the context of cancer. Several reports suggest that inflammatory signals induced in the tumor milieu regulate the functional fate and antitumor activity of Th17 cells. Recent findings also point to significant alterations in Th17 cells due to their interplay with regulatory T lymphocytes and cytotoxic CD8(+) T cells within the tumor microenvironment. Finally, an appreciation for the stem cell-like properties of Th17 cells that augment their persistence and activity emerges from recent reports. The impact of these factors on Th17 cells' antitumor efficacy and how these factors may be exploited to improve cancer therapies will be discussed.