gebhart/patrepeval huggingface dataset:
Ti3+-defected and V-doped TiO2quantum dots loaded on MCM-41 (2013)

V-doped TiO2 quantum dots (QDs) possessing many Ti(3+) defects were fabricated by simple hydrolysis using MCM-41 as a support. The QDs show high charge-separation efficiency and high photocatalytic activity due to the quantum size effect and the newly formed defect- and dopant-mediated band levels.
Competing Coordination and Oxygen Atom Transfer in a Reaction Between Triarylphosphines and a Chromium Hydroperoxo Complex (2005)

Article Competing Coordination and Oxygen Atom Transfer in a Reaction Between Triarylphosphines and a Chromium Hydroperoxo Complex was published on October 1, 2005 in the journal BioInorganic Reaction Mechanisms (volume 5, issue 4).
Steric Acceleration of Activated Ene Reactions. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Survey of Permanent Magnet for a Laser-Assisted Heating Magnetization to Generate Designed Surface Magnetic Flux Density Distribution for Magnetic Mems Devices (2022)

To realize high-performance micro magnetic devices such as energy harvesters and micro actuators, a fine-pitch and multi-pole magnetization method for permanent magnets are required to reduce the self-demagnetizing field in the magnet and increase the surface magnetic flux density. We are developing a multi-pole micro magnetization method that combines a local coercivity reduction of the permanent magnet by laser-assisted heating with an external reverse magnetic field. However, the designed surface flux density has not been obtained. Using the proposed magnetization method, we have experimentally investigated the relationship between magnet material and magnetization results. Experimental results show that using highly heated resistant magnets produces the surface flux density of the permanent magnets closer to the design values.
RESPONSE OF CHILE PEPPER (Capsicum annuum L.) TO SALT STRESS AND ORGANIC AND INORGANIC NITROGEN SOURCES: II. NITROGEN AND WATER USE EFFICIENCIES, AND SALT TOLERANCE (2011)

The response to two nitrogen sources on water and nitrogen use efficiencies, and tolerance of salt-stressed chile pepper plants (Capsicum annuum L.) cv. Sandia was investigated in a greenhouse experiment. Low, moderate and high (1.5, 4.5, and 6.5 dS m-1) salinity levels, and two rates of organic-N fertilizer (120 and 200 kg ha-1) and 120 kg ha-1 of inorganic fertilizer as ammonium nitrate were arranged in randomized complete block designs replicated four times. The liquid organic-N source was an organic, extracted with water from grass clippings. Water use decreased about 19 and 30% in moderate and high salt-stressed plants. Water use efficiency decreased only in high salt-stressed plants. Nitrogen use efficiency decreased either by increased salinity or increased N rates. An apparent increase in salt tolerance was noted when plants were fertilized with organic-N source compared to that of inorganic-N source.
Preparation of Uridine Diphosphate- N -Acetylgalactosamine from Uridine Diphosphate- N -Acetylglucosamine by Using Microbial Enzymes (1981)

A method was developed for the large scale preparation of uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) from uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by means of microbial enzymes. With Bacillus subtilis cell-free extract as a source of UDP-GlcNAc 4-epimerase, about 35% of the UDP-GlcNAc added was converted to UDP-GalNAc. After the residual UDP-GlcNAc was degraded to uridine triphosphate and N-acetylglucosamine-1-phosphate with a protamine-treated extract of bakers' yeast as a source of UDP-GlcNAc pyrophosphorylase, UDP-GalNAc was separated by anion-exchange column chromatography. The nucleotide was recovered by adsorption on charcoal and elution with ammoniacal ethanol. The final yield was about 100 mumol.
Thermally induced optical bistability in ZnSe epilayers grown by molecular-beam epitaxy (1990)

For the first time, ZnSe epitaxial layers grown by molecular-beam epitaxy are shown to exhibit large contrast, low power, and extremely long-term stable thermally induced absorptive optical bistability. It is observed over a wide temperature range between 169 K and RT, with a strongly variable loop width and a switch-back adjustable to be less than 50% of the respective switch-down value. Critical slowing down as well as switch-down times are studied in dependence of the excess over the switch-down intensity values.
Lisp-based agent platform and applications for inter-domain network management (2007)

The Internet consists of several thousand interconnected autonomous systems (ASes). For enabling the autonomous network management that ensures stable access at the inter-AS level and flexible inter-domain routing control, it is important to know how the routing information originated from an AS spreads throughout the Internet and to control inter-AS routing information using feedback actions based on observed network status at multiple ASes. Because each AS is controlled by a single administrative authority based on that AS's own policy, a cooperative distributed problem solving is desirable. To cope with these requirements, we have proposed a multi-agent-based inter-AS diagnostic system called ENCORE and inter-AS routing adjustment system called AISLE / VR. They consist of a collection of intelligent agents that are located in multiple ASes and perform collective observation, analysis, and control. These systems are constructed on the agent platform that provides utility functions on distributed environments. For the purpose of flexibility for incremental design and modification through the development and application phases, we adopted Lisp as the base language and have constructed stable systems that can demonstrate the effectiveness of our basic design for autonomous inter-AS network management.
Characterization of high-temperature thermographic phosphors: spectral properties of LuPO_4:Dy(1%),Eu(2%) (1995)

The fluorescence properties of a thermographic phosphor in the form of single crystals of LuPO4: Dy(1%),Eu(2%) have been studied as a function of temperature by the use of a high-temperature oven integrated into a spectrophotometer. The results reveal differing rates of decrease in the fluorescence intensity with increasing temperature for various emission lines of dysprosium and europium, thus suggesting a new differential method of remote thermometry for high-temperature applications and for temperature measurements on moving components.
Assessment of Cognitive and Neurologic Recovery in Ischemic Stroke Drug Trials: Results from a Randomized, Double-blind, Placebo-controlled Study. (2016)

<b>Objective.</b> Ischemic stroke is a serious medical condition with limited therapeutic options. The evaluation of the therapeutic potential of novel pharmacological interventions is carried-out in Phase II trials. The study design, primarily intended to evaluate efficacy and safety, is a balance between utilizing as few patients as possible to minimize safety risk and enrolling sufficient patients to detect unambiguous efficacy signals. We sought to determine whether post-stroke recovery outcomes based on behavioral measures of cognitive and motor impairment yielded additional information beyond that of clinician-based methods. <b>Design.</b> This was a multicenter, multinational, randomized, parallel group, controlled versus placebo, efficacy, and safety study of PF-03049423 for treatment of acute ischemic stroke. <b>Settings and participants.</b> Our study subjects were acute ischemic stroke inpatients. <b>Measurements.</b> Outcome measures were derived from rating scales (Modified Rankin Scale, Barthel Index, and National Institutes of Health Stroke Scale) and behavioral tests (Box and Blocks Test, Hand Grip Strength Test, 10-Meter Walk Test, Repeatable Battery Assessment of Neuropsychological Status Naming and Coding Subtests, Line Cancellation Test, and Recognition Memory Test). Assessments were performed at Days 7, 14, 30, 60, and 90. <i>Post-hoc</i> analyses of correlations among the outcome measures at each measurement time point on a cohort of 137 subjects were conducted. <b>Results.</b> Results support the validity of measures from Box and Blocks Test, Hand Grip Strength Test, 10-Meter Walk Test, and Repeatable Battery Assessment of Neuropsychological Status Coding Subtests to monitor post-stroke recovery in clinical trial settings. Notably, the Recognition Memory Test did not show a correlation with the Modified Rankin Scale, and, in fact, did not show improvement over time. <b>Conclusion.</b> The behavioral measures of cognitive and motor functions included in this study may extend the evaluation of the therapeutic potential of new treatments for stroke recovery. The lack of correlation between Recognition Memory Test and the traditional efficacy endpoints, at least in part due to absence of any improvement in recognition memory, suggests that there may be cognitive elements not detected by the Modified Rankin Scale. This is clinically relevant and memory improvement has potential as an endpoint in future trials aiming to improve certain aspects of cognition.
Data from Neoadjuvant Intratumoral Immunotherapy with TLR9 Activation and Anti-OX40 Antibody Eradicates Metastatic Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;The combination of the synthetic TLR9 ligand CpG and agnostic OX40 antibody can trigger systemic antitumor immune responses upon co-injection into the tumor microenvironment, eradicating simultaneous untreated sites of metastatic disease. Here we explore the application of this &lt;i&gt;in situ&lt;/i&gt; immunotherapy to the neoadjuvant setting. Current neoadjuvant checkpoint blockade therapy is delivered systemically, resulting in off-target adverse effects. In contrast, intratumoral immunotherapy minimizes the potential for toxicities and allows for greater development of combination therapies. In two metastatic solid tumor models, neoadjuvant intratumoral immunotherapy generated a local T-cell antitumor response that then acted systemically to attack cancer throughout the body. In addition, the importance of timing between neoadjuvant immunotherapy and surgical resection was established, as well as the increased therapeutic power of adding systemic anti-PD1 antibody. The combination of local and systemic immunotherapy generated an additional survival benefit due to synergistic inhibitory effect on tumor-associated macrophages. These results provide a strong rationale for translating this neoadjuvant intratumoral immunotherapy to the clinical setting, especially in conjunction with established checkpoint inhibitors.&lt;/p&gt;Significance:&lt;p&gt;This work demonstrates the ability of neoadjuvant intratumoral immunotherapy to target local and distant metastatic disease and consequently improve survival.&lt;/p&gt;&lt;/div&gt;
Completely explosive pulsed power minisystem (2003)

It is demonstrated that it is feasible to produce pulsed power using an autonomous completely explosive system that harnesses two physical phenomena successively: the transverse shock wave demagnetization of Nd2Fe14B high-energy hard ferromagnets and magnetic cumulation.
REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding (2017)

REFOLDdb is a unique database for the life sciences research community, providing annotated information for designing new refolding protocols and customizing existing methodologies. We envisage that this resource will find wide utility across broad disciplines that rely on the production of pure, active, recombinant proteins. Furthermore, the database also provides a useful overview of the recent trends and statistics in refolding technology development.
Kinetics of the Low Salinity Waterflooding Effect Studied in a Model System (2013)

Abstract Low salinity waterflooding (LSF) provides an opportunity for improved oil recovery. However the complexity of the process makes both the fundamental understanding of the underlying mechanism(s) and the interpretation of laboratory experiments difficult. Therefore we use a model system for sandstone which consists of clay minerals deposited on a glass substrate and covered with crude oil droplets in order to study the kinetics of oil detachment when exposed to low salinity brine. The system is equilibrated first under high saline brine and then exposed to brines of varying (lower) salinity while the shape of the oil droplets is continuously monitored at high resolution allowing for a detailed analysis of the contact angle and the contact area as a function of time. We observe that the contact angle and contact area of oil with the substrate reach a stable equilibrium at high saline brine and show a clear response to the low salinity brine towards less oil wetting conditions and ultimately detachment from the clay (Na-montmorillonite) substrate. This behavior is characterized by the motion of the 3-phase (oil-water-solid) contact line which is initially pinned by clay particles at high salinity conditions and that pinning decreases upon exposure to low salinity brine leading to a decrease in contact area and contact angle which indicates wettability alteration towards a more water-wet state. When the contact angle reaches a critical value around 40-50°, oil drops start to detach from the clay. During detachment most of the oil is released but in some cases a small amount of oil residue is left behind on the clay substrate. Our results for different salinity levels indicate that the kinetics of this wettability change correlates with a simple buoyancy over adhesion force balance and has a time constant of hours to days; i.e., it takes longer than commonly assumed. The unexpectedly long time constant, i.e. longer than expected by diffusion alone, is compatible with an electrokinetic model. It is an important finding which provides new insights into the pore-scale mechanism of LSF and also has implications for the execution of low salinity coreflooding experiments, i.e. provides how long it takes to reach equilibrium and at which time scale a response to LSF can be expected.
SpoIIAB is an anti-sigma factor that binds to and inhibits transcription by regulatory protein sigma F from Bacillus subtilis. (1993)

The sigma F factor is a regulatory protein that is responsible for directing gene expression in the forespore compartment of developing cells of the spore-forming soil bacterium Bacillus subtilis. The sigma F factor is encoded by the promoter-distal member of sporulation operon spoIIA, which consists of cistrons called spoIIAA, spoIIAB, and spoIIAC. Genetic evidence indicates that the activity of sigma F is negatively regulated by the product (SpoIIAB) of the spoIIAB cistron. We now report that SpoIIAB is capable of binding to sigma F and inhibiting its capacity to direct transcription by core RNA polymerase from the promoter for a forespore-expressed gene. SpoIIAB is an anti-sigma factor that may be directly involved in the compartmentalization of sigma F-directed gene expression.
Bed temperature modeling and forecasting of Circulating Fluidized Bed boiler based on SMO algorithm (2010)

Considering the properties of Circulating Fluidized Bed boilers (CFB) such as distribution parameters, time variation, nonlinearity, multivariable coupling, etc, A new bed temperature modeling and forecasting method of CFB based on SMO algorithm is proposed. Moreover, as to the real bed temperature data of a 300 MW coal gangue power plant, the proposed method was used to get the dynamic model. Simulation results show that this algorithm has higher prediction accuracy and faster computational speed than the traditional BP neural network algorithm; it also has a significant practical and application value to the control of bed temperature of CFB.
Effect of Pentoses and Pentitols on Fermentation of Hay by Mixed Populations of Ruminal Microorganisms (1988)

Consecutive batch culture, a technique which involves sequential transfer of cultures to fresh medium at regular intervals, was used to establish mixed ruminal-microbial populations in an anaerobic medium containing highly digestible hay. Once volatile fatty acid production was stable, perturbations were imposed in consecutive cultures by the addition of one of each of the following pentoses or analogous pentitols: l-arabinose, d-lyxose, d-ribose, d-xylose, l-arabitol, d-arabitol (lyxitol), ribitol, and xylitol. With the exception of d-lyxose, the addition of pentoses caused marked increases in propionate and valerate production, and except for d-arabitol, pentitol addition caused increases in butyrate and valerate production. On transfer to and continued incubation in the control medium, volatile fatty acid production reverted to preperturbed levels. The presence of pentitols and pentoses significantly reduced the endpoint pH of cultures and the proportion of hay that was fermented. With all added substrates, the response to the perturbation was at its maximum within one incubation (i.e., within 48 h). Similarly, the variables being monitored all returned to control levels within one incubation. On the basis of these results, it is suggested that changes were related to the need to maintain a redox balance within anaerobic cultures rather than any significant changes in the microbial population that was present.
1P-072 Versatile techniques in making of a protein Hamming library for the fast systematic directed evolution(Protein:Engineering, The 47th Annual Meeting of the Biophysical Society of Japan) (2009)

Analyg]g of a Natively UnfoldLd PieteLn by Combining Molecular Modelmg and goTution X iay Scatte"ng
Reduced emotion processing efficiency in healthy males relative to females (2012)

This study examined sex differences in categorization of facial emotions and activation of brain regions supportive of those classifications. In Experiment 1, performance on the Facial Emotion Perception Test (FEPT) was examined among 75 healthy females and 63 healthy males. Females were more accurate in the categorization of fearful expressions relative to males. In Experiment 2, 3T functional magnetic resonance imaging data were acquired for a separate sample of 21 healthy females and 17 healthy males while performing the FEPT. Activation to neutral facial expressions was subtracted from activation to sad, angry, fearful and happy facial expressions. Although females and males demonstrated activation in some overlapping regions for all emotions, many regions were exclusive to females or males. For anger, sad and happy, males displayed a larger extent of activation than did females, and greater height of activation was detected in diffuse cortical and subcortical regions. For fear, males displayed greater activation than females only in right postcentral gyri. With one exception in females, performance was not associated with activation. Results suggest that females and males process emotions using different neural pathways, and these differences cannot be explained by performance variations.
Hypoxia modifies the feeding preferences of Drosophila. Consequences for diet dependent hypoxic survival (2010)

Chronically hypoxic flies modify their feeding behavior. They avoid dietary yeast which appears to be toxic. Hypoxic survival is dependent on a source of exogenous sucrose. Ultimately, dietary yeast reduces hypoxic survival by reducing the intake of sucrose. The results highlight the importance of behavioral mechanisms in the responses of Drosophila to chronic hypoxic conditions.
[The antisera avidity]. (1984)

In a LN-equivalence point titration system the modulation of immune complex formation of high avide antisera by specific and unspecific factors is measurable. Protamine-Cl is a potent enhancer of complex formation.
OPTICAL FREQUENCY TRANSLATION OF MODE-LOCKED LASER PULSES (1966)

Optical frequency translation of pulses from a mode-locked laser is described and demonstrated experimentally. The laser beam is passed through a crystal of LiNbO3 whose refractive index is made to change sinusoidally at the mode-locked laser round-trip frequency (56 Mc/sec). A Doppler shift of the laser light results. Shifts of ±2.4 Gc/sec have been observed. The scheme may be capable of producing shifts as large as ±1000 Gc/sec.
Multitasking by Multivalent Circular DNA Aptamers (2006)

Nucleic acid aptamers are finding increasing applications in biology, especially as therapeutic candidates and diagnostic components. An important characteristic in meeting the needs of these applications is improved stability in physiological fluids, which is most often accomplished with chemical modification or unnatural nucleotides. In an alternative approach we have specified the design of a multivalent circular DNA aptamer topology that encompasses a number of properties relevant to nucleic acid therapeutic candidates, especially the ability to multitask by combining different activities together within a modular structure. Improved stability in blood products, greater conformational stability, antidoting by complementary circular antiaptamers, heterovalency, transcription factor decoy activity and minimal unintended effects upon the cellular innate immune response are desirable properties that are described here. Multitasking by circular DNA aptamers could similarly find applications in diagnostics and biomaterials, where the combination of interchangeable modules might generate new functions, such as anticoagulation coupled with reversible cell capture as, described here. These results provide a platform for further exploration of multivalent circular aptamer properties, especially in novel combinations of nucleic acid therapeutic modes.
Natural variation in root exudation of GABA and DIMBOA impacts the maize root endosphere and rhizosphere microbiomes (2022)

Root exudates are important for shaping root-associated microbiomes. However, studies on a wider range of metabolites in exudates are required for a comprehensive understanding about their influence on microbial communities. We identified maize inbred lines that differ in exudate concentrations of 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and γ-aminobutyric acid (GABA) using a semi-hydroponic system. These lines were grown in the field to determine the changes in microbial diversity and gene expression due to varying concentrations of DIMBOA and GABA in exudates using 16S rRNA amplicon sequencing and metatranscriptomics. Results showed individual and interaction effects of DIMBOA and GABA on the rhizosphere and root endosphere β-diversity, most strongly at the V10 growth stage. The main bacterial families affected by both compounds were Ktedonobacteraceae and Xanthomonadaceae. Higher concentrations of DIMBOA in exudates affected the rhizosphere metatranscriptome, enriching for metabolic pathways associated with plant disease. This study validated the use of natural variation within plant species as a powerful approach for understanding the role of root exudates on microbiome selection. We also showed that a semi-hydroponic system can be used to identify maize genotypes that differ in GABA and DIMBOA exudate concentrations under field conditions. The impact of GABA exudation on root-associated microbiomes is shown for the first time.