gebhart/patrepeval huggingface dataset:
Imagination in Autism: A Chance to Improve Early Language Therapy (2021)

Children with autism often have difficulties in imaginative play, Theory of Mind, and playing out different scenarios in their minds. Research shows that the root of these problems may be the voluntary imagination network that involves the lateral prefrontal cortex and its long frontoposterior connections to the temporal-parietal-occipital area. Previously disconnected visuospatial issues (<i>stimulus overselectivity</i> and <i>tunnel vision</i>) and language issues (lack of comprehension of spatial prepositions and complex recursive sentences) may be explained by the same voluntary imagination deficit. This review highlights the new insights into the mechanism of voluntary imagination, its difference from involuntary imagination, and its unusually strong critical period. Clearer developmental terminology and a better understanding of voluntary imagination have the potential to facilitate communication between therapists and parents, and improve therapy outcomes in children.
Broken Legs Are to Be Walked on (1977)

nursing program and an adjunct faculty member at Johnston-Willis Hospital, Richmond, Va. She and Dr. Deyerle coauthored Your Total Hip Replacement, a pamphlet published by the Orthopaedic Equipment Company of America. New developments in the field of orthopedics are often the reinforcement of past knowledge or the restoration of a forgotten technique(1). This is certainly true of ambulation and weight bearing as a treatment for fractures of the femur.
A Semantic DOM Approach for Webpage Information Extraction (2009)

With the development of electronic technology and e-commerce, technology for Web pages has attracted a lot of research efforts which becomes one of the hottest topics recently. This paper has proposed a semantic DOM (SDOM) approach for information extraction of e-commerce Web pages. With the combination of content and structure information, the precision and recall can achieve a good result which is shown in our experiments on listpage and tablepage data sets.
Reproductive Behavior and Social Organization of the Pomacanthid Fish Genicanthus lamarck at Mactan Island, Philippines (1984)

RANDALL, J. E. 1967. Food habits of reef fishes of the West Indies. Stud. Trop. Ocean. 5:665-847. RESHETNIKOV, Y. S., R. CLARO AND A. SILVA. 1972. The pattern of feeding and the rate of digestion in some tropical predatory fish. J. Ichthyol. 12:818824. ROBERTSON, D. R., AND S. G. HOFFMAN. 1977. The roles of female mate choice and predation in the mating systems of some tropical labroid fishes. Z. Tierpsychol. 45:298-320. SALE, P. F. 1980. The ecology of fishes on coral reefs. Oceanogr. Mar. Biol. Ann. Rev. 18:367-421. STARCK, W. A., AND W. P. DAVIS. 1966. Night habits of fishes of Alligator Reef, Florida. Ichthyologica 38:313-356. SVENSON, W. A., AND L. L. SMITH. 1973. Gastric digestion, food consumption, feeding periodicity and food conversion efficiency in the walleye (Stizostedion vitreum vitreum).J. Fish. Res. Bd. Can. 30:13271336. TALBOT, F. H., B. C. RUSSELL AND G. R. V. ANDERSON. 1978. Coral reef fish communities: unstable, high-diversity systems? Ecol. Monogr. 48:425-440. TESCH, F. W. 1971. Age and growth, p. 98-130. In: Methods for assessment of fish production in fresh waters. W. E. Ricker (ed.). Blackwell Scientific Publ. Oxford.
Wideband and deep penetration of photon-number fluctuations into quantum regime in series-connected light-emitting diodes (2002)

Summary form only given. We present our experimental results on wideband (-60 MHz) noise suppression of output photon fluxes below the standard quantum limit (SQL) level from series-connected LEDs at room temperature. Particularly, the degree of the noise suppression in series-connected LEDs is demonstrated to be substantially larger than that in a single LED driven through an equivalent series resistor. Series-connected AlGaAs LEDs (HE8812SG) were driven directly by a constant voltage source.
Optimal Design of Vibration Absorber Systems Supported by Elastic Base (1991)

Abstract This paper presents the effect of foundation flexibility on the optimum design of vibration absorbers. Flexibility of the base is incorporated into the absorber system equations of motion through an equivalent damping ratio and stiffness value in the direction of motion at the connection point. The optimum values of the uncoupled natural frequency and damping ratio of the absorber are determined over a range of excitation frequencies and the primary system damping ratio. The design parameters are computed and compared for the rigid, static, and dynamic models of the base as well as different levels of base flexibility.
Factors encouraging laparotomy in acalculous pholecystitis (1985)

Because it is difficult to diagnose, acalculous cholecystitis in critically ill patients is treated frequently in an advanced stage. Three of 1600 cardiac surgery ICU admission cases and five of 500 general surgical ICU admission cases were analyzed retrospectively to determine which variables expedited diagnosis and might have encouraged earlier surgery. Vague right upper quadrant physical findings and nonspecific changes in liver function chemistries led frequently to radiologic evaluations. Noninvasive diagnostic procedures such as ultrasound and hepatobiliary scans were helpful but frequently inconclusive. Of the eight patients, the five survivors were diagnosed while still in the hyperdynamic hemodynamic state of early sepsis. Cholecystostomy performed early under local anesthesia was the safest procedure in this group of critically ill patients. After other sources of sepsis such as suppurative phlebitis, yeast septicemia, catheter sepsis, and other extra-abdominal sources such as soft-tissue, urinary, and pulmonary infections have been ruled out, hemodynamic data obtained from pulmonary artery catheters inserted during the early phase of sepsis increase diagnostic accuracy and should expedite surgical exploration.
The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens (2016)

Spironucleus vortens is a protozoan parasite associated with significant mortalities in the freshwater angelfish, Pterophyllum scalare. Control of this parasite is especially problematic due to restrictions on the use of the drug of choice, metronidazole (MTZ), on fish farms. Use of garlic (Allium sativum) is undergoing a renaissance following experimental validations of its antimicrobial efficiency. Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), is a stable transformation product of allicin, the primary biologically active component of garlic. In the current study, an ajoene oil crude extract had a minimum inhibitory concentration (MIC) of 40μg/ml against S. vortens. GC-MS and NMR spectroscopy revealed this ajoene extract contained a mixture of the (E) and (Z)-ajoene isomers along with diallyl disulphide (DADS) and diallyl trisulphide (DATS). The only component of the ajoene crude oil found to substantially inhibit S. vortens growth by optical density monitoring (Bioscreen C Reader) was (Z)-ajoene (MIC 16μg/ml). Ajoene oil acted in synergy with MTZ in vitro, reducing the individual MIC of this drug (4μg/ml) by 16-fold, and that of ajoene oil by 200-fold with a fractional inhibitory concentration (FIC) index of 0.263. This synergistic interaction was confirmed in vivo. S. vortens-infected Pterophyllum scalare angelfish dosed orally with 0.5% (v/w) MTZ combined with 0.05% (v/w) ajoene displayed a significant reduction in faecal trophozoite count, whilst those fed on 0.5% MTZ flakes (half the recommended oral dose) alone did not. This study demonstrates for the first time the synergistic interaction between the synthetic drug MTZ and natural ajoene oil both in vitro and in vivo. Future work should evaluate the potential synergy of ajoene and MTZ against MTZ-resistant bacteria and protists.
Combination of white minerals with natura tannins: chrome-free tannage for garment leathers (2004)

Leucine-rich repeat proteins expressed in the developing vertebrate nervous system comprise a complex, multifamily group, and little is known of their developmental function in vivo. We have identified a novel member of this group in Xenopus laevis, XlNLRR-6, and through sequence and phylogenetic analysis, have placed it within a defined family of vertebrate neuronal leucine-rich repeat proteins (NLRR). XlNLRR-6 is expressed in the developing nervous system and tissues of the eye beginning at the neural plate stage, and expression continues throughout embryonic and larval development. Using antisense morpholino oligonucleotide (MO) -mediated knockdown of XlNLRR-6, we demonstrate that this protein is critical for development of the lens, retina, and cornea. Reciprocal transplantation of presumptive lens ectoderm between MO-treated and untreated embryos demonstrate that XlNLRR-6 plays autonomous roles in the development of both the lens and retina. These findings represent the first in vivo functional analysis of an NLRR family protein and establish a role for this protein during late differentiation of tissues in the developing eye.
Synthesis of a Dipeptidyl Peptidase 4 Inhibitor (2009)

The target molecule is in development for the treatment of type 2 diabetes because it inhibits dipeptidyl peptidase 4 (DPP-4) leading to a reduction in elevated blood glucose levels. The key step in the synthesis is an asymmetric ­nucleophilic addition of Grignard reagent E to the N-tert-butanesulfinimine D.
MASCOT - Structures design and qualification of an "organic" mobile pander platform for low gravity bodies (2014)

The DLR Mobile Asteroid Surface Scout (MASCOT) is an approx. 10kg shoebox-sized lander platform developed in cooperation with CNES and JAXA for the Hayabusa 2 Asteroid Mission heading to the C-class asteroid 1999 JU3. MASCOT carries four scientific instruments as well as a mobility mechanism for up righting and relocation on the asteroid during autonomous operation. The MASCOT system is subdivided in two main structural composite parts, the Landing Module (LM), housing all experiments and sub-systems, and the Mechanical and Electrical Support Structure (MESS). It provides the LM’s interface to Hayabusa 2 until separation. This paper provides an insight into the structural design concept, development and corresponding mechanical flight qualification for both parts.
Supplementary Figure from CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease (2023)

Supplementary Figure from CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease
Safety and efficacy from the phase 1 SURPASS trial of ADP-A2M4CD8, a next-generation T-cell receptor T-cell therapy, in patients with advanced esophageal, esophagogastric junction, or gastric cancer. (2023)

349 Background: ADP-A2M4CD8 is a specific peptide enhanced affinity receptor mixed CD4+ and CD8+ T-cell therapy targeting the cancer testis antigen MAGE-A4 and modified with addition of a CD8α co-receptor designed to provide additional functionality to CD4+ T-cells. ADP-A2M4CD8 has demonstrated a favorable benefit to risk profile in the Phase 1 SURPASS trial (NCT04044859) in HLA A*02–eligible patients (pts) with unresectable or metastatic tumors positive for MAGE-A4 (Hong DS, et al. E-poster 540P: ESMO 2021; Virtual). Here we report updated clinical outcomes in pts with esophageal, esophagogastric junction (EGJ), or gastric cancer. Methods: SURPASS is a first-in-human trial consisting of a modified 3+3 dose-escalation design and an expansion cohort. Autologous T-cells are obtained by leukapheresis, transduced with a self-inactivating lentiviral vector expressing the MAGE-A4-specific T-cell receptor and the CD8α co-receptor, and infused back to the pts as ADP-A2M4CD8 following lymphodepleting chemotherapy. Primary and secondary objectives are safety and anti-tumor activity, respectively. Results: As September 6, 2022, 13 pts (11 male, 2 female) with esophageal (3), EGJ (8), and gastric cancer (2) received ADP-A2M4CD8 (range: 1.02–9.9x10 9 transduced T-cells). All pts had adenocarcinoma, median age was 55 years (range: 31–71), median MAGE-A4 expression H-score was 245 (range: 160–300), and pts received median of 2 lines of prior therapy (range 1–5). Adverse events (AEs) were consistent with those typically associated with lymphodepleting chemotherapy, cellular therapy, and/or disease. One pt had a Grade 5 (fatal) AE of pancytopenia. Overall response rate per RECIST v1.1 by investigator review was 15% (2 partial response [PR]). Disease control rate was 77% (2 PR+8 stable disease). This trial is ongoing, and additional data will be presented. Conclusions: Results indicate an acceptable benefit to risk profile and encouraging anti-tumor activity of ADP-A2M4CD8. An additional treatment cohort has been included in the updated SURPASS trial protocol to evaluate ADP-A2M4CD8 combined with nivolumab. A Phase 2, open-label trial in advanced esophageal and EGJ cancers has been initiated (SURPASS-2; NCT04752358). Clinical trial information: NCT04044859 .
Design and optimization of dual rotor motor for electric vehicle application (2014)

Selection of a particular motor type for electric vehicle application is a very challenging task. Dual rotor motor (DRM) drive train due to its high torque density and compact size in comparison to drive trains with multiple motors has emerged as a potential alternative to conventional motor types such as permanent magnet motor and induction motors. Due to the presence of three magnetically coupled motor parts, design and optimization of DRM geometry becomes a complex job. In this paper different configurations of a particular type of DRM have been analyzed using finite element analysis (FEA). The FEA results obtained provides a clear understanding of the interaction of three fields as well as insight to the motor design aspects.
Delayed toxicities with anti-PD-1 and anti-PDL-1 immune checkpoint inhibitors (ICIs). (2018)

e15074 Background: ICI use is associated with immune-related adverse events (irAEs). Most irAEs occur early (within 3 months), but data regarding late toxicities is not well reported. Methods: Patients (pts) treated with ICIs (nivolumab [PD-1], pembrolizumab [PD-1], or atezolizumab [PDL-1]) were identified from pharmacy records across MedStar Health Network hospitals. The CTCAE 4.03 grading system was used to define irAEs. Pts who received distinct ICIs at separate time points were considered as separate events. We defined delayed toxicities as irAEs that developed 1 year after the first dose of ICI either on or off treatment (pts who did not receive subsequent therapies). Pts in whom irAEs developed during or after subsequent therapies were excluded from analysis. Results: We identified 325 pts who received 328 ICI therapies. 26% (n = 59) of pts developed any grade (grd) irAEs, with 8% (n = 26) of pts developing grd ≥3 irAEs. Of irAEs, 55% (n = 73) occurred within 3 months, 35% (n = 47) in between 3 to 12 months and 10% (n = 13) after 12 months. Of delayed irAEs, 46% (n = 6) of pts were on ICIs and 54% (n = 7) were off ICIs at the time of irAE onset. In the off treatment delayed irAE cohort, 70% of pts developed grd ≥2 irAEs, including colitis (grd 3, n = 1), joint pain (grd 3, n = 1), neurological toxicity (grd 2, n = 1), mucositis (grd 3, n = 1), and hypothyroidism (grd 2, n = 1). Of this cohort, five pts required systemic steroids. irAEs resolved within two weeks except one case in which colitis took 6 months to resolve. 12% (n = 40) of pts continued ICIs beyond 1 year, in which 15% (n = 6) developed delayed irAEs. These delayed irAEs were joint pain (grd 1, n = 1), pruritis (grd 1, n = 1), rash (grd 2, n = 1), hypothyroidism (grd 1, n = 1), hyponatremia (grd 1, n = 1) and colitis (grd 3, n = 1). Colitis required systemic steroid use and took 6 weeks to resolve, after which ICI was discontinued. In the pt with grd 2 rash, treatment with ICIs was continued. Conclusions: Findings from our retrospective study suggest that 15% of pts who continue ICIs beyond 1 year are at risk of developing delayed irAEs, which may require chronic immunosuppressive therapy. Delayed irAEs should be considered in discussions about treatment cessation in pts with major responses to ICIs.
Simultaneous Real-Time Measurements of Mastication, Swallowing, Nasal Airflow, and Aroma Release (2003)

Mastication, swallowing, breath flow, and aroma release were measured simultaneously in vivo using electromyography, electroglottography, a turbine air flow meter, and the MS-Nose, respectively. Signals were synchronized either electronically or by aligning the nasal airflow data with the breath by breath release of acetone. Chewing affected nasal airflow, with the flow fluctuations following the mastication pattern. Data analysis suggested that air was pumped out of the mouth into the throat with each chew, and the mean volume was 26 mL. Aroma release was associated with the pulses of air pumped from the mouth with each chew. During swallowing, there was no nasal airflow, but after swallowing, aroma release was evident. The volume of the retronasal route was estimated at 48 mL when swallowing and 72 mL when samples were chewed. The combination of techniques shows the effects of physiological processes on aroma release.
The greater effectiveness of Glomus mosseae and Glomus intraradices in improving productivity, oil content and tolerance of salt‐stressed menthol mint (Mentha arvensis) (2012)

Better performance in terms of herb yield, and oil content and yield was observed in Gi- and Gm-inoculated M. arvensis plants, suggesting the capability of Gi and Gm in protecting plants from the detrimental effects of salt stress; beneficial effects of arbuscular mycorrhizal fungi, however, may vary with host and environment.
Exudative Age-related Macular Degeneration (2002)

In Japan, exudative age-related macular degeneration is defined as a condition in which lesions originating from choroidal neovascularization (CNV) develop in the macular area in association with aging. The symptoms include central scotoma, metamorphopsia, and irreversible and advanced visual impairment. Serous or hemorrhagic retinal pigment epithelial detachment or retinal detachment, subretinal hemorrhage, subretinal connective tissue formation, and scar lesions are noted in the macular area. Fluorescein and indocyanine green can be used as fluorescent dyes for fluorescein angiography, and photocoagulation is per formed when choroidal neovascularization outside the fovea is visible on angiograms obtained with either dye. When the CNV involves the fovea, photocoagulation of the entire subfoveal CNV, photocoagulation of the feeder vessel of the neovascular- ization, interferon therapy, low-dose radiotherapy, submacular surgery, transloca- tion of the macula, transpapillary thermotherapy, and photodynamic therapy are attempted. Vitreous surgery is performed to remove vitreous hemorrhages originat- ing from the CNV, and procedures for transferring or eliminating subretinal hemato- mas are performed to treat large subretinal hemorrhages involving the fovea.
Learning State Representations for Query Optimization with Deep Reinforcement Learning (2018)

We explore the idea of using deep reinforcement learning for query optimization. The approach is to build queries incrementally by encoding properties of subqueries using a learned representation.
Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex. (1996)

We used the human atrial natriuretic peptide (hANP) gene as a model to investigate the causal relationship between immediate early gene expression and the subsequent activation of the embryonic gene repertoire in cardiac hypertrophy. Using transient transfection analysis, we found that overexpression of individual Jun family members, alone or in combination, displayed unique activity that varied as a function of the promoter and the nature of the transfected myocyte populations under examination. In neonatal cardiac ventriculocytes, both c-jun and to a lesser extent, JunB stimulated hANP promoter activity (approximately 7- and 3- fold, respectively). When cotransfected together, a synergistic activation was observed (approximately 16-fold activation), a finding that stands in contrast to the behavior of JunB (i.e. neutral or inhibitory) with other 12-O- tetradeconoylphorbol 13-acetate response element-dependent promoters. In atriocytes, on the other hand, JunB did not itself activate the hANP promoter, and it antagonized c-jun- mediated transcription. JunD, a third member of this gene family, was devoid of activity in these transfected cultures. These findings suggest that the hANP gene promoter exhibits a broad range of responses to the individual products of the jun gene family. The response in any single situation is a function of the relative concentrations and subunit composition of the prevailing activator protein-1 complexes.
Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics (2011)

In this prospective study, we used a sensitive multimodality platform to identify and characterize an essentially uniform but opposite pattern of disruption in sphingomyelin and ceramide mass levels in AD plasma. Given the role of brain sphingolipids in neuronal function, our findings provide new insights into the AD sphingolipidome and the potential use of metabolomic signatures as peripheral biomarkers.
Targeting Ku protein for sensitizing of breast cancer cells to DNA-damage (2004)

Targeting molecular components that are critically involved in the maintenance of genome stability is a promising approach for overcoming intrinsic tumor cell resistance to DNA-damaging treatments. In mammalian cells, the Ku-dependent non-homologous end-joining repair pathway is the predominant process for the repair of double-strand breaks (DSBs) in DNA. Previously, RNA aptamers were selected to efficiently block DNA-binding activity of the Ku protein in vitro. In the present study, we have tested the efficacy of RNA aptamers against the Ku protein as molecular sensitizer of MCF-7 breast carcinoma cells to DNA-damage. Toward this end, we established MCF-7 cell sublines stably expressing SC4 aptamer RNAs under the control of the human 7SL small nuclear RNA gene promoter. Vector-transfected (MCF/7SL) cells and cells stably expressing SC4 aptamers (MCF/SC4) were exposed to the anticancer drug etoposide and cellular responses to DNA-damage were evaluated. We found that the presence of RNA aptamers against Ku protein enhanced etoposide-induced growth inhibition of MCF-7 breast cancer. The SC4 aptamer-mediated sensitization of MCF-7 cells to the anticancer drug is attributable to an increased susceptibility of these cells to apoptosis. The observed effects cannot be accounted for by the differential expression levels of Ku protein in control and SC4 aptamer-expressing cells, but are rather due to augmented DNA binding-capacity of Ku protein, as demonstrated in in vitro studies. Thus, RNA aptamers against Ku protein show potential to sensitize MCF-7 breast carcinoma cells to DNA-damaging agents.