gebhart/patrepeval huggingface dataset:
P3‐009: Butyrylcholinesterase, Aβ and thioflavin‐S plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer's disease (2011)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes cognitive and behavioral impairment. It is characterized by the accumulation of amyloid plaques and neurofibrillary tangles. Histochemical analyses of AD brain tissue have shown BuChE to be present in ß-amyloid (Aß) plaques and neurofibrillary tangles (NFTs). In addition, it has been found that when BuChE is associated with plaques that they are in a more malignant, ß-pleated, thioflavin-S positive form. It is not clear whether the BuChE associated with Aß plaques is causative of AD, interferes with disease progression or is an epiphenomenon. An animal model that develops similar BuChE-associated Aß plaques, could help elucidate the role of BuChE in this pathology. The B6.Cg-Tg (APPSWE/PSEN1dE9) 85Dbo/j transgenic mouse was used to determine if BuChE associates with Aß plaques in a mouse model of AD. Four mice, aged 15.5 months, were used in this study. Brain tissue was stained using Aß immunohistochemistry, thioflavin-S and BuChE histochemistry. Plaque loads were quantified using NIH ImageJ software and recorded as a percentage of the total area. We found that this animal model develops Aß and thioflavin-S plaques with BuChE activity (Figure 1). The pathology seen, in terms of morphology, distribution and abundance of Aß, thioflavin-S and BuChE plaques, closely resembled many aspects seen in AD. There was a high correlation in the distribution and abundance of Aß, thioflavin-S and BuChE plaques. Furthermore, based on the percent of area covered by pathology, BuChE staining was less than Aß staining but more than thioflavin-S staining. Ab, thioflavin-S and BuChE plaques were found in cortical and hippocampal areas as well as in olfactory structures, amygdala and the cerebellum. There were few scattered plaques in the thalamus, striatum and certain fibre tracts as well. β-amyloid immunohistochemistry, thioflavin-S staining and butyrylcholinesterase histochemistry in a 15.5 month old B6. Cg-Tg (APPSWE/PSEN1dE9) 85Dbo/j mouse. scale bar = 1mm. Based on the work with this APP/PS1 Cg-Tg mouse model, BuChE association with Aß plaques may represent an intermediate stage in the development of malignant, ß-pleated, thioflavin-S positive plaques. Further study with this animal model may help elucidate the role of BuChE in AD pathology.
Phosphorylation and redistribution of the phosphatidylinositol-transfer protein in phorbol 12-myristate 13-acetate- and bombesin-stimulated Swiss mouse 3T3 fibroblasts (1993)

By immunofluorescence microscopy it was shown that the phosphatidylinositol-transfer protein (PI-TP) becomes associated with the Golgi membranes when confluent (quiescent) Swiss mouse 3T3 fibroblast cells are stimulated with phorbol 12-myristate 13-acetate (PMA) and bombesin. Dibutyryl cyclic AMP or dexamethasone had no effect on the intracellular redistribution of PI-TP. In exponentially growing cells and in serum-starved (semi-quiescent) cells, PI-TP is already associated with Golgi structures. Stimulation of semi-quiescent cells by PMA resulted in a rapid redistribution of PI-TP. A similar yet slower response was observed after stimulation with bombesin. Stimulation of semi-quiescent 3T3 cells by PMA significantly increased the phosphorylation of PI-TP, as shown by immunoprecipitation of PI-TP from pre-labelled cells. No significant increase in phosphorylation of PI-TP was observed after stimulation of these cells by bombesin. Purified PI-TP was shown to be a substrate for protein kinase C in vitro. The possibility that the phosphorylation of PI-TP after activation of protein kinase C is involved in the observed redistribution of PI-TP is discussed.
PLT 27 Gas Turbine Engine Exhaust Emission and Noise Measurements (1974)

Abstract : PLT 27 gas turbine engine exhaust gas and noise were measured and analyzed. The results of the exhaust gas emission analysis show that the exhaust gases have a low content of unburned combustion products, i.e., hydrocarbons and carbon monoxide, down to idle power due to the high combustion efficiency of this engine. The combustion efficiency is 99.5 percent at idle and 99.9 percent above 10 percent of maximum-rated power. The smoke numbers of the PLT 27 engine are extremely low. No visible smoke was produced at any power setting with any of the injector systems tested. The PLT 27 engine meets the exhaust gas emission standards set by the EPA for 1979 for fixed-wing aircraft.
ChemInform Abstract: Aerobic Oxidation of Sulfides to Sulfoxides Catalyzed by Gold/Manganese Oxides (2014)

Abstract Review: 40 refs.
Synthesis of Ru(.eta.5-C5Me5)(.eta.4-C5H4O)Br: Formation of an Unprecedented Bis(water) Adduct Exhibiting a Two-Dimensional Hydrogen-Bonded Water Network (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Ru(.eta.5-C5Me5)(.eta.4-C5H4O)Br: Formation of an Unprecedented Bis(water) Adduct Exhibiting a Two-Dimensional Hydrogen-Bonded Water NetworkKarl Kirchner, Kurt Mereiter, Klaus Mauthner, and Roland SchmidCite this: Organometallics 1994, 13, 9, 3405–3407Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/om00021a011https://doi.org/10.1021/om00021a011research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation (2013)

Alloreactivity of donor lymphocytes leads to graft-versus-host disease (GVHD) contributing to significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Within the past decade, significant progress has been made in elucidating the mechanisms underlying the immunologic dysregulation characteristic of GVHD. The recent discoveries of different cell subpopulations with immune regulatory function has led to a number of studies aimed at understanding their role in allogeneic HCT and possible application for the prevention and treatment of GVHD and a host of other immune-mediated diseases. Preclinical animal modeling has helped define the potential roles of distinct populations of regulatory cells that have progressed to clinical translation with promising early results.
Marvin Scott Warned Me That Goffman Did Not Like People Writing About Him, That We Should Only Write About Dead People (2007)

Dr. Andreas Fontana, Professor of Sociology at the University of Nevada Las Vegas, wrote this memoir at the invitation of Dmitri Shalin and gave his approval for posting the present version in the Erving Goffman Archives.
Lesion protection during fixed‐wire balloon angioplasty: Use of the “buddy wire” technique and access catheters (1992)

Fixed-wire (FW) coronary angioplasty procedures have gained widespread acceptance in some institutions as a primary choice for all angioplasty procedures. These single-lumen, low-profile devices provide distinct advantages as compared to over-the-wire systems in certain circumstances. However, they have not allowed for lesion protection or guidewire access if the situation arises. Two techniques are available to provide lesion protection during FW coronary angioplasty. They are the buddy wire technique and the use of subselective intracoronary access catheters. Access catheters can be used as primary, pre-loaded devices or as secondary devices to be used over an extended FW balloon catheter. These techniques can widen the applications of FW balloon angioplasty.
Applying Filtering Techniques to Improve GPS Positioning Accuracy (2001)

A Kalman filter was developed to improve the DGPS position estimates in non-stationary applications. Applying Kalman filtering to the raw DGPS measurement data couldeffectively remove the DGPS position noise and reduce the standard deviation of the positioningerror. In our parallel tracking study, the maximum cross-tracking error (XTE) was reduced from9.83 m to 2.76 m by the Kalman filtering. The Kalman filter also reduced the standard deviationof the XTE from 0.33 m to 0.30 m. The performance of the Kalman filter was compared to thatof a mean filter. It was found that the Kalman filter had much smaller positioning error than themean filter in the direction of travel. In our study, the average positioning errors in the directionof travel were 1.35 m for the mean filter, and 0.20 m for the Kalman filter. The GPS bias errorwas found to be the major source of the cross-tracking error. Further study is needed toestimate and reduce the GPS bias error for parallel tracking applications.
Membrane-permeabilizing activities of Bacillus thuringiensis coleopteran-active toxin CryIIIB2 and CryIIIB2 domain I peptide (1994)

Bacillus thuringiensis toxin CryIIIB2 exhibits activity against two agriculturally important pests, the Colorado potato beetle, Leptinotarsa decemlineata, and the Southern corn rootworm, Diabrotica undecimpunctata. CryIIIB2 shows significant structural similarity to Colorado potato beetle-active toxin CryIIIA, whose crystal structure has been determined elsewhere [J. Li, J. Carrol, and D. J. Ellar, Nature (London) 353:815-821, 1991]. A clone limited to the putative 7-alpha-helical bundle domain I peptide of CryIIIB2 was constructed by PCR. The truncated protein was expressed at high levels in Escherichia coli. Domain I peptide was isolated and compared with native CryIIIB2 toxin in promoting ion efflux from synthetic phospholipid vesicles and formation of ion channels in black lipid membranes. The results showed that CryIIIB2 domain I peptide is sufficient for ion channel formation and promotes ion efflux. Both native CryIIIB2 toxin and domain I peptide were inefficient channel-forming proteins that produced noisy ion channels of various conductance states. In ion efflux assays, native toxin promoted greater ion efflux from synthetic vesicles than did the truncated peptide.
Mouvement d'une bulle dans un liquide. Applications de l'effet fusée (fonctionnement des pompes érosion de cavitation, modèles réduits, ébullition usinage par électroérosion et par ultrasons, etc.) (1969)

Une bulle de gaz ou de vapeur de volume variable et en mouvement de translation dans un liquide est soumise à des accélérations importantes. Celles-ci entraînent des variations considérables de densité d'énergie cinétique de translation. Ce phénomène que nous appelons « l'effet fusée » trouve des applications dans les domaines les plus divers. Nous l'avons considéré successivement dans l'écoulement d'une émulsion à l'intérieur d'une pompe centrifuge, dans l'érosion de cavitation, dans quelques problèmes d'hydraulique, dans l'ébullition, dans l'usinage par ultrasons ou par électroérosion, dans la formation des aérosols et dans quelques autres cas possibles.
Emergency Destruction of Information Storing Media (1987)

Abstract : This IDA Report was prepared for the Commander, Space and Naval Warfare Systems Command and the National Computer Security Center. It provides a basis for analyzing the appropriateness of various destruction technologies in the emergency destruction of information storing media. The support task was structured as a multi-year effort, with interim reports and updates, ultimately leading to a research plan for developing specific destruction techniques, equipment, and procedures. The prior interim reports are incorporated into this final iteration. The Report comprises three volumes: Emergency Destruction of Information Storing Media; Appendix I, Analysis Matrix; and Appendix II, Destruct Technology Compendium.
Measurement of electrons from semileptonic heavy-flavor hadron decays inppcollisions ats=7  TeV (2012)

The differential production cross section of electrons from semileptonic heavy-flavor hadron decays has been measured at midrapidity ($|y|&lt;0.5$) in proton-proton collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ with ALICE at the LHC. Electrons were measured in the transverse momentum range $0.5&lt;{p}_{\mathrm{t}}&lt;8\text{ }\text{ }\mathrm{GeV}/c$. Predictions from a fixed-order perturbative QCD calculation with next-to-leading-log resummation agree with the data within the theoretical and experimental uncertainties.
Enhancement of light extraction of GaN-based light-emitting diodes with a microstructure array (2004)

An optical model for simulating light extraction efficiency of a GaN-based LED chip is presented. We propose the introduction of a periodic sharpening structure on the interface between the sapphire and the n-GaN of a GaN-based LED to obtain as high as 78% light extraction efficiency.
Dielectrophoresis-Raman spectroscopy system for analysing suspended WO 3 nanoparticles (2011)

Dielectrophoresis (DEP) utilizing a curved microelectrode pattern was developed and integrated with a Raman spectroscopy system. The electrodes were patterned on a Raman transparent quartz substrate, and integrated with a microfluidic channel in poly-dimethylsiloxane (PDMS). This integrated system can be efficiently used for the determination of suspended particles type and the direct mapping of their spatial concentrations. It will be demonstrated that the integration of Raman mapping with dielectrophoretically controlled WO<sub>3</sub> particles can be used for studying suspended particles <i>in situ</i>.
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine. (1992)

As aminoguanidine (AG) is known to prevent non-enzymatic glycosylation in various tissues, we have histologically and biochemically evaluated AG effects on the skin in control, SZ-diabetic and AG-treated (25 mg/kgbw/day, 10w) diabetic rats. HbA1c and plasma glucose levels in diabetic and AG-treated diabetic rats were maintained about two times higher than those in control rats during the 10 weeks of the experiment. Histological findings revealed that the dermis in diabetic rats was thin and edematous, associated with swelling and degeneration of collagen fibers. Necrobiotic changes were seen in the lower dermis. These changes were greatly improved in AG-treated diabetic rats. Skin glucose contents in diabetic and AG-treated diabetic rats were about 10 times higher than those in the controls, whereas there was no difference in the sorbitol contents between three groups. Dry weight of the skin and collagen content was well correlated (r = 0.9044) and collagen represented 78.0 +/- 2.3% of the dry weight. By SDS-PAGE analysis of cyanogen bromide digests it was shown that high molecular weight peptides were increased in diabetic rats, but were decreased in AG-treated diabetic rats. The mean of glycosaminoglycan (GAG) contents of diabetic skin was 54% of that in the controls (1.58 +/- 0.09 vs. 2.94 +/- 0.39 micrograms/mg dry weight, P < 0.0025), which increased significantly in AG-treated diabetic rats (1.75 +/- 0.07 microgram/mg dry weight, P < 0.01 vs. diabetic).(ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of a novel fibre fractionation hydrocyclone (2006)

The morpho-functional organization correlated to photosensitivity in Cnidaria is that of ocelli and extraocular photoreception. Several examples of the second type of organization are reported. The photosensitivity of the cnidarian Hydra is of the extraocular (neural or dermal) type. The effects of photic stimulation (applied according to various experimental protocols: steady condition; step stimulus; single, twin, or repetitive pulses; different polarities and chromaticities of steady, step and pulse stimulation and different phases of pulse application) on the modulation of various bioelectric events linked to the periodic behaviour of the animal are reviewed. The mechanisms correlated with the photobehaviour of Hydra, as well as the problems still open on the molecular mechanisms of phototransduction, are discussed.
Specifying telephone systems in LOTOS (1993)

A method for detecting feature interactions in the design of telephone systems using LOTOS (language of temporal ordering specifications) is described. The specification discussed includes call forwarding on a busy line, setting a three-way call, and call waiting. The ways in which a specification of a telephone system involving such features can be constructed in LOTOS and the ways in which LOTOS tools can be used to detect unwanted interactions of the features are illustrated using simple examples. The techniques used are step-by-step execution, symbolic execution, and compositional execution with test processes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin (2011)

This kind of novel engineered nanosize PEGylated EPO has remarkable advantages over rhEPO.
A paper-based microfluidic platform with shape-memory-polymer-actuated fluid valves for automated multi-step immunoassays (2019)

Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic devices. In this work, we present an integrated paper-based microfluidic platform with shape-memory polymer (SMP)-actuated fluid valves capable of automated colorimetric enzyme-linked immunosorbent assays (ELISAs). A single-layer microfluidic paper-based analytical device (μPAD) was designed to store all the reagents on the chip, and sequentially transfer reagents to a paper test zone following a specific ELISA protocol through automatic fluidic flow control by the multiple SMP-actuated valves. The actuation of a paper valve was based on the thermally responsive, duel-state shape transformation of a SMP sheet attached to the root of a paper cantilever beam for driving a hydrophilic paper bridge to connect and disconnect two paper channels. A portable colorimetric reader was developed to control the on-chip valve operations, quantify the colorimetric signal output, display the assay result, and wirelessly transmit the data to a smart phone for the application of telemedicine. Reliable operations of the paper valve and the entire μPAD were demonstrated with success rates of 97% and 93%, respectively. A detection mechanism for valve malfunction was designed and confirmed effective to identify any mal-operation of individual valves, thus rendering our platform reliable in real assays. For device calibration, we conducted direct ELISAs of rabbit IgG in phosphate-buffered saline (PBS), and achieved a low limit of detection (LOD) of 27 pM (comparable to that of standard and paper-based ELISAs). In order to demonstrate the clinical application of our multi-step immunoassay platform, we also conducted sandwich ELISAs to quantify the protein level of an inflammatory cytokine, namely tumor necrosis factor (TNF)-α, in surgically injured laryngeal tissues of rats. The protein levels of TNF-α were shown similar between the conventional and μPAD ELISAs.
X-ray digital intra-oral tomosynthesis for quasi-three-dimensional imaging: system, reconstruction algorithm, and experiments (2013)

At present, there are mainly three x-ray imaging modalities for dental clinical diagnosis: radiography, panorama and computed tomography (CT). We develop a new x-ray digital intra-oral tomosynthesis (IDT) system for quasi-three-dimensional dental imaging which can be seen as an intermediate modality between traditional radiography and CT. In addition to normal x-ray tube and digital sensor used in intra-oral radiography, IDT has a specially designed mechanical device to complete the tomosynthesis data acquisition. During the scanning, the measurement geometry is such that the sensor is stationary inside the patient’s mouth and the x-ray tube moves along an arc trajectory with respect to the intra-oral sensor. Therefore, the projection geometry can be obtained without any other reference objects, which makes it be easily accepted in clinical applications. We also present a compressed sensing-based iterative reconstruction algorithm for this kind of intra-oral tomosynthesis. Finally, simulation and experiment were both carried out to evaluate this intra-oral imaging modality and algorithm. The results show that IDT has its potentiality to become a new tool for dental clinical diagnosis.
The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo (2017)

The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activities including anticancer effects. However, the anti-colorectal cancer effects and the potential molecular mechanisms of the ethanol extracts of sporoderm-broken spores of G. lucidum (BSGLEE), which mainly contains triterpenoids, have not been reported. The aim of the present study was to investigate the anticancer effects and molecular mechanisms exerted by BSGLEE on colorectal cancer in vitro and in vivo. MTT assay revealed that BSGLEE at 1.6 to 10 mg/ml significantly inhibited HCT116 cell proliferation in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that BSGLEE induces apoptosis and cell cycle arrest at G0/G1 phase, which are associated with deregulation of the expression of key genes and proteins (p21, p16, cyclin D1, Bcl-2, bax, NAG-1, PARP and caspase-3) that regulate apoptosis and cell cycle cascades. Moreover, BSGLEE significantly inhibited HCT116 cell migration via downregulating MMP-1, MMP-2 and upregulating E-cadherin expression at mRNA levels. Oral gavage of 75 and 150 mg/kg BSGLEE significantly inhibited HCT116 xenograft tumor growth in nude mice, which was accompanied by suppressed Ki-67 staining as determined by immunochemistry. Collectively, we found that BSGLEE effectively inhibits colorectal cancer carcinogenesis through induction of apoptosis, inhibition of migration and promotion of cell cycle arrest. Our results suggest that triterpenoids of sporoderm-broken spores of G. lucidum ethanol extracts may serve as a promising anticancer agent for colorectal cancer chemoprevention and therapy.