gebhart/patrepeval huggingface dataset:
The role of neural networks in the study of the posterior parietal cortex (2002)

The use of a neural network model of a cerebral cortical area as an aid to understanding this area's function is reviewed. The basic model is a feedforward multilayer network that learns to transform the coordinates of a visual stimulus from a retinocentric to a craniocentric reference frame using backpropagation. An extension of the model to one that transforms retinal coordinates into body-centered ones predicts response properties that are confirmed by neurophysiological experiments. The simulation of electrical stimulation of the model predicts a pattern of effects similar to the one obtained by stimulation of a specific region of the parietal cortex. The study of the response properties of the model's units provides a simple explanation of how the parietal cortex might compute coordinate transformations and of why certain manipulations such as stimulation should produce the effects observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Indirect Detection of Glycosidases Using Amperometry (2016)

Glycosidases are essential enzymes that cleave glycoside bonds. The presence of glycosidases have been widely used to detect pathogens, label cells/tissues, and report specific diseases. We have developed a rapid electrochemical assay to detect glycosidases. Exposure of electrochemically inactive substrates to glycosidases releases glucose, which can be measured easily using an electrochemical cell. Five different glycosidases were detected rapidly within 1 h using disposable electrodes. This assay could readily be incorporated into repurposed glucose meters to rapidly detect glycosidases, which in turn could be useful to report the presence of a pathogen or illness.
Reduced Brainstem Inhibition during Anticipated Pelvic Visceral Pain Correlates with Enhanced Brain Response to the Visceral Stimulus in Women with Irritable Bowel Syndrome (2008)

Cognitive factors such as fear of pain and symptom-related anxiety play an important role in chronic pain states. The current study sought to characterize abnormalities in preparatory brain response before aversive pelvic visceral distention in irritable bowel syndrome (IBS) patients and their possible relationship to the consequences of distention. The brain functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) response to anticipated and delivered mild and moderate rectal distention was recorded from 14 female IBS patients and 12 healthy controls. During cued anticipation of distention, activity decreased in the insula, supragenual anterior cingulate cortex (sACC), amygdala, and dorsal brainstem (DBS) of controls. IBS patients showed less anticipatory inactivation. Group differences were significant in the right posterior insula and bilateral DBS. Self-rated measures of negative affect during scanning were higher in patients than controls (p < 0.001), and the anticipatory BOLD decreases in DBS were inversely correlated with these ratings. During subsequent distention, both groups showed activity increases in insula, dorsal ACC, and DBS and decreases in the infragenual ACC. The increases were more extensive in patients, producing significant group differences in dorsal ACC and DBS. The amplitude of the anticipatory decrease in the pontine portion of DBS was associated with greater activation during distention in right orbitofrontal cortex and bilateral sACC. Both regions have been associated previously with corticolimbic inhibition and cognitive coping. Deficits in preparatory inhibition of DBS, including the locus ceruleus complex and parabrachial nuclei, may interfere with descending corticolimbic inhibition and contribute to enhanced brain responsiveness and perceptual sensitivity to visceral stimuli in IBS.
EUV telecentricity and shadowing errors impact on process margins (2015)

Monte Carlo simulations are used in the semiconductor industry to evaluate variability limits in design rule generation, commonly for interaction between different layers. The variability of the geometry analyzed is determined mainly by the lithography, process and OPC used. Monte Carlo methods for design rule evaluation can provide the requisite level of accuracy, and are suitable for two or more layer interactions because the variations on one can be assumed to be independent of variations on the other(s). The variability parameters and budget utilized in optical Monte Carlo simulations is well-established. With the upcoming implementation of EUV lithography the variability budget will be impacted. EUV has an off-axis illumination angle that complicates the lithography process by causing telecentricity and shadowing errors. Telecentricity errors manifest as a printed feature being shifted relative to the design. The amount the feature is shifted is a function of the pattern density and design. Shadowing is caused by the 3D nature of the mask combined with EUV reflective mask technology. A shadow occurs at feature edges, where the source does not fully illuminate. Telecentricity and shadowing errors, although small at the 10 nm node, will increase in relative size compared to the features printed beyond the 7 nm node. Telecentricity and shadowing errors are complex in nature and can’t be compensated for with a flat bias. These errors unique to EUV are incorporated into Monte Carlo simulations and evaluated against the standard cell design layers. The effect of these variability parameters is evaluated on critical 7 nm node layout clips.
Palm Oil by Dry Fractionation: Impact of Tri-saturated Triacylglycerol Content on the Process Efficiency (2021)

editorial reviewed
ChemInform Abstract: RAPID OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS BY THE “FILTRATION” METHOD (1985)

Abstract Die Kondensation der beiden Nucleotide (I) und (II) bzw. (V) und (VI) zu (VII) wird in Lösung vorgenommen.
High frequency longitudinal-transverse complex vibration systems for ultrasonic wire bonding (2002)

High frequency longitudinal to transverse complex vibration systems of 160 kHz to 1 MHz for ultrasonic wire ball bonding for IC or LSI are studied. Vibration systems of these high frequency and complex vibration welding equipments consist of transverse free-free complex vibration rod 7.0 mm in diameter, two longitudinal vibration systems for driving the transverse vibration rod and a ceramic capillary 1.5875 mm in diameter. Vibration distribution of capillary at high frequency up to 1 MHz is measured at the first time and the conventional capillary is revealed applicable at such high frequencies.
Securing a Remote Terminal Application with a Mobile Trusted Device (2005)

Many real-world applications use credentials such as passwords as means of user authentication. When accessed from untrusted public terminals, such applications are vulnerable to credential sniffing attacks, as shown by recent highly publicized compromises. In this paper, we describe a secure remote terminal application that allows users possessing a trusted device to delegate their credentials for performing a task to a public terminal without being in danger of disclosing any long-term secrets. Instead, the user gives the terminal the capability of performing a task temporarily (as long as the user is in its proximity). Our model is intuitive in the sense that the user exposes to the untrusted terminal only what he sees on the display, and nothing else. We present the design and implementation of such a system. The overhead - in terms of additional network traffic - created by introducing a trusted third party is a moderate 12%.
Phase I clinical and pharmacokinetic evaluation of high-dose mitoxantrone in combination with cytarabine in patients with acute leukemia. (1993)

The recommended phase II dose of mitoxantrone is 80 mg/m2 administered over 15 minutes as a single intravenous infusion in combination with cytarabine 3 g/m2/d for 5 days. At this dose, high concentrations of mitoxantrone are achievable in vivo to levels that have been shown to be extremely cytotoxic in vitro.
On flexible topology formation in publish-subscribe networks (2012)

In this work we analyze topology discovery and the procedure for joining the network in the information-centric context. We develop and evaluate such a network attachment procedure in an information-centric network utilizing the publish-subscribe paradigm for the data exchange. In our work the publish-subscribe concept is not only used as a communication means, but we aim at fully exploiting its characteristics for native merging of fine-grained network operations such as topology management and network connectivity establishment. Such an integration adds not only to the simplicity of the network and efficiency of the network information gathering, but includes the means for handling mobility issues. We examine the performance characteristics of the proposed solution particularly focusing on complexity and introduced message overhead. The evaluation results obtained from the testbed experiments show the outstanding performance in terms of delay, while the signaling overhead remains at a very low level.
Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(iii)-binding metabolites directly from bacterial culture supernatants (2008)

Nickel(II)-based immobilized metal affinity chromatography (IMAC) has been used to capture from standard samples the hydroxamate-containing siderophores, acetohydroxamic acid (ahaH), suberodihydroxamic acid (shaH(2)) or desferrioxamine B (DFOB) in recoveries ranging between 35-90%. The capacity of a 1 mL Ni(II)-charged IMAC column towards DFOB capture at the pH optima of 8.9 is approximately 3000 nmol. This method has been used for the direct capture of DFOB (approximately 65% recovery) from the untreated supernatant of iron-deprived cultures of Streptomyces pilosus, the soil bacterium from which DFOB was first discovered. In addition to selecting for DFOB and a related siderophore, two other Fe(III)-responsive species have been identified from RP-HPLC analysis of the IMAC-processed eluant from the S. pilosus supernatant. Since the characterisation of siderophores from natural systems is hampered by the low yields obtained from traditional purification methods, this IMAC-based affinity method offers significant potential for improving yields of this key class of bioligands and other small molecule metabolites with affinities to IMAC-compatible metal ions.
[Effect of GABA-positive substances on the primary and mirror epileptogenic foci in the hippocampus of rats]. (1986)

The effects of beta-alanine, phenibut and muscimol on the activity of the "mirror" (MEF) and primary (PEF) epileptogenic foci were studied in rats on the model of penicillin-induced epilepsy using the direct administration of the drugs into the foci (muscimol only into MEF). All the drugs suppressed the development of electrographic correlates of seizures both in PEF and MEF. The varied characters of the drugs' effects on interseizure epileptiform bursts depending on administration into PEF (provocation) or MEF (no effect) were revealed. Possible dose-dependent mechanisms of the drugs' actions on GABA-A and GABA-B receptors involved in inhibitory control of the activity of epileptogenic foci in the rat hippocamp are discussed.
A cloud service discovery approach based on FCA (2012)

Cloud computing has attracted great interest from both academic and industrial communities. More and more cloud services have been developed in the cloud computing environments. But it is a challenging task to discovery the suitable service from large number of services efficiently. We present in this paper a new service discovery approach based on FCA. First, filter irrelevant services by availability parameter and semantic distance similarity, then handle the nonfunctional QoS attributes with FCA, classify services by their QoS levels and select suitable service for user. We use OWLS-TC to validate our service discovery approach and the results show that our approach not only provide suitable service for user, but also very efficient.
Noncentral Force Model for Hexagonal Close‐Packed Crystal Lattices (1967)

Abstract A Born‐von Karman model of the hexagonal close‐packed lattice was considered using a combination of central and angular forces between various sets of neighbors. The interactions between nearest neighbors in the plane were regarded as central forces while the interactions between nearest neighbors out of the plane and next nearest neighbors out of the plane were considered to be noncentral, i.e. both central and angular. Three materials with different axial ( c / a ) ratios were considered: beryllium (1.568), magnesium (1.624), and zinc (1.855). The equations of motions were evolved and the force constants were related to the elastic constants of the material. The eigenvalues of the secular equation were solved for one hundred twenty one (121) points in that portion of the Brillouin zone irreducible under symmetry operations. The frequency spectrum for each material was obtained from these eigenvalues. The temperature dependence of the specific heat of each material was calculated using the appropriate frequency distribution function. The Debye characteristic temperature and the Einstein characteristic temperature were also obtained as a function of temperature.
Células de carga inteligentes (1994)

Este artigo descreve a implementaçãoo de uma arquitectura de procesamento de sinal das células de carga, muito simples, bastante eficaz e de baixo custo, desenvolvida em torno de um microcontrolador RISC e tirando partido da característica ratiomérica da saída das células de carga. Para amplificaçãoo e filtragem dos sinais aplicaram-se as técnicas de condensadores comutados. A necessidade de estabilidde térmica dos circuitos e componentes é minimizada devido ao uso da mesma cadeia de amplificação para o sinal e referência em conjunto com o software de calibração. A conversão analógico-digital é feita através do método de rampa simples, sendo controlado pelo microcontrolador que realiza todo o processamento digital necessário, bem como a comunicação série com o exterior. Também é descrito um exemplo de software de calibração duma plataforma de pesagem com várias células de craga "inteligentes".
The Design and Implementation of a High-Performance Active Network Node (1998)

A capsule-oriented active network transports capsules containing code to be executed on the network nodes that they pass through. This approach makes networks more extensible by allowing new networking protocols to be deployed and used without any changes to the underlying network infrastructure. This thesis project describes the design, implementation, and evaluation of a high-performance practical active network node that can serve as a testbed for research into active network performance and resource management issues. Nodes provide resources to executing capsules containing Intel ix86 object code. Although the current implementation does not yet provide safety or interoperability, the results of experiments performed on the system implemented for this thesis indicate that an active network architecture may be able to provide significant flexibility while only incurring a small performance overhead relative to traditional networks.
Design and performance of micro-rectenna arrays for thermal energy harvesting (2015)

We report on the design and performance of a micro-rectenna device for harvesting wasted thermal energy. As an individual rectenna exhibits low efficiency and output power, we designed and studied a focal plane array (FPA) on a single semiconductor chip. Our FPA could be used for more general energy-harvesting applications as well as for THz imaging.
Reviewer #2 (Public Review): Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia (2023)

Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. This augmented adverse remodelling after I/R and led to an increased infarct size and deterioration of cardiac function. In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction.
Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease (2004)

Donepezil has a beneficial effect on memory and may improve other cognitive deficits in patients with PD and cognitive impairment. However, variable tolerability in our sample underscores the need for careful monitoring when prescribing donepezil to patients with PD, especially with dosage increases.
Effect of interactions between spray jets on liquid distribution in a fluidized bed (2016)

Abstract In Fluid Cokers™, banks of spray nozzles are used to inject oil into a bed of hot coke particles. The purpose of this study is to determine whether interactions between spray jets could enhance liquid distribution on hot coke particles, which is crucial to improve the operability and performance of Fluid Cokers. A low temperature experimental model of Fluid Coking was used to measure the liquid distribution. Preliminary screening of nozzle positions employed conductance measurements. A binder solution was utilized to further investigate the most interesting nozzle interactions, by simulating at low temperature the formation of agglomerates during high temperature coking. Adding different dyes to the binder solutions injected by the different nozzles helped determine how nozzles interacted. With two synchronized nozzles of the same size, the liquid distribution is greatly improved when the spray jets slightly merge due to the expansion time being significantly reduced. The merged spray jets result in an unstable single jet, which allows for bubbles to be released faster from the spray jet. Because the volume of the released bubble is about the same for individual and merged jets, the jets do not contract as much upon bubble release: this enhances the jets' ability to capture gas bubbles from the bed, accelerating their expansion. Fewer agglomerates are also produced due to the improved liquid distribution.
An Object-Oriented Testing Framework Specified in Z Notation (1999)

ABSTRACT

Many researches to testing object-oriented programs (OOPs) have been proposed for the past decade. However, most of these researches have centered only around the class-level testing instead of the whole profiles of OOP development. This paper presents a framework to test OOPs from em formal specification to em test data generation. The formal specification of object-oriented program is specified in Z notation which is a mathematically rigorous specification language. A state transition diagram (STD) derived from Z specification provides a complementary representation of the dynamic behavior of a given OOP. In addition, the STD can be used to generate a test data which consists of anticipated operation sequences of OOPs. Moreover, a testing algorithm modeled by em finite state machine is proposed to run against test data. Two important testing criteria, consistency and completeness (C & C), are used to evaluate testing result. The final test result shows that the testing framework is executable and pragmatic.
Determination of the heat resistance of spores using a solid heating block system (1985)

A simple and accurate technique for the determination of the heat resistance of spores is described. The technique combines a modified capillary tube method with a solid heating block. The come-up time of spore suspensions was found to be short and simple and accurate technique is suggested for the correction of the come-up times. Experimental results are presented for the destruction of spores of Bacillus stearothermophilus at 120 degrees which indicates the accuracy and reproducibility of the new method.
Extending the Service Life of Electric Distribution and Transmission Wooden Poles Using a Wet Layup FRP Composite Strengthening System (2010)

This paper investigates the feasibility of using an in situ wet layup fiber-reinforced polymer (FRP) repairing system to extend the service life of electric distribution and transmission wooden poles. The effectiveness of the FRP strengthening method was evaluated through field tests performed on Class-4 deteriorated wooden poles and a step-by-step rapid installation procedure was developed. Results indicated that the application of the in situ wet layup FRP system increased the load capacity of the poles where more than 85% of their original capacity was restored. In addition, the repaired poles exceeded the minimum lateral load required by the NESC and ANSI 05.1 codes indicating that it would be more cost-effective repairing the poles than replacing them. Moreover, in addition to the cost savings, the FRP system extended the service life of the deteriorated poles up to 30 years.
Promoting pepper (Capsicum annuum) photosynthesis via chloroplast ultrastructure and enzyme activities by optimising the ammonium to nitrate ratio (2020)

Optimal plant growth in many species is achieved when the two major forms of N are supplied at a particular ratio. In this pot experiment, the effects of five different ammonium:nitrate ratios (ANRs) (0:100, 12.5:87.5, 25:75, 37.5:62.5, and 50:50) on photosynthesis efficiency in chilli pepper (Capsicum annuum L.) plants were evaluated. The results showed that an ANR of 25:75 increased the contents of chl a, leaf area and dry matter, whereas chl b content was not affected by the ANRs. Regarding chlorophyll fluorescence, an ANR of 25:75 also enhanced the actual photochemical efficiency, photochemical quenching and maximum photosynthetic rate. However, the 0:100 and 50:50 ANRs resulted in higher values for nonphotochemical quenching. An inhibition of maximal photochemical efficiency was found when 50% NH4+ was supplied at the later stage of plant growth. The addition of 25% or 37.5% NH4+ was beneficial for gas exchange parameters and the 25% NH4+ optimised the thylakoid of chloroplasts. Compared with nitrate alone, 12.5–50% NH4+ upregulated glutamate dehydrogenase (GDH), the large subunit and the small subunit of Rubisco. It can be concluded that the 25:75 ANR accelerated N assimilation through active GDH, which provides a material basis for chloroplast and Rubisco formation, resulting in the increased photosynthetic rate and enhanced growth in chilli pepper.
Measurement Precision in a Series of Visual Fields Acquired by the Standard and Fast Versions of the Swedish Interactive Thresholding Algorithm (2014)

Although SITA Standard is a more precise testing algorithm than SITA Fast at lower VF sensitivities, it is unlikely to make a sizeable difference to improving the time to detect VF progression.