gebhart/patrepeval huggingface dataset:
Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen (2002)

Delayed pulmonary toxicity syndrome after high-dose chemotherapy (HDC) and autologous hematopoietic support occurs in up to 64% of women with advanced-stage breast cancer. Using a similar, but nonmyeloablative, HDC treatment regimen in mice, we found both immediate and persistent lung injury, coincident with marked decreases in lung tissue glutathione reductase activity and accompanied by increases in lung oxidized glutathione, bronchoalveolar lavage (BAL) lipid peroxidation, and BAL total cell counts. Most interestingly, at 6 wk, BAL total cell counts had increased fourfold, with lymphocyte cell counts increasing >11-fold. A single supplemental dose of glutathione prevented early lung injury at 48 h but showed no lung-protective effects at 6 wk, whereas single doses of other thiol-sparing agents (Ethyol and glutathione monoethyl ester) showed no benefit. These data suggest that this HDC regimen results in acute and persistent lung toxicity, induced in part by oxidative stress, that culminates with an acute lung cellular inflammatory response. Continuous glutathione supplementation and/or attenuation of the delayed pulmonary inflammatory response may prove beneficial in preventing lung toxicity after the use of these chemotherapeutic agents.
Preparation and characterization of monoclonal antibodies to human adiponectin for its quantitative measurement in serum (2012)

Mouse Monoclonal antibodies against human adiponectin were produced by the routine method and the specificity of antibodies was verified. These monoclonal antibodies (MoAbs) interacted with the monomeric and trimeric forms of recombinant adiponectin according to the results of a Western blot analysis. Human blood serum was fractionated by gel filtration, and the protein of these fractions was stained using labeled MoAbs. It was established that a single high-molecular-weight form (HMW) of endogenous adiponectin was detected by this method. The use of competitive enzymelinked immunoassay on the basis of the obtained MoAbs allowed us to show that the sera of healthy male donors contains lower adiponectin concentrations than that of female donors (8.42 ± 1.59 μg/ml vs. 11.01 ± 2.58 μg/ml, p = 0.01). We also detected statistically significant lower adiponectin levels in the serum of patients with coronary artery disease for both men (6.01 ± 2.73 μg/ml vs. 8.42 ± 1.59 μg/ml, p = 0.015) and women (5.79 ± 2.98 μg/ml vs. 11.01 ± 2.58 μg/ml, p = 0.0003). Therefore, the developed methods for the analysis of the HMW form of adiponectin can be helpful in the diagnostics of the possible implications and assessment of unfavorable prognoses in patients with cardiovascular disorders.
Are stentless aortic heterografts suitable for right ventricular outflow tract reconstruction? An experimental study in juvenile sheep. (1999)

Allograft valved conduits are used routinely for reconstruction of the right ventricular outflow tract in children with congenital heart disease; however, allografts are scarce. The purpose of this study was to evaluate two stentless aortic valves that might be suitable alternatives for right ventricular outflow tract reconstruction. Twelve juvenile sheep underwent implantation of stentless aortic heterografts as an interposition in the pulmonary artery: six porcine aortic valves (Freestyle) and six fully pericardial valves (Pericarbon stentless). In each series, three valves were explanted after 3 months, the other three after 6 months. Valves were analyzed by gross inspection, radiography, and light microscopy. The porcine aortic stentless valve (Freestyle) showed extensive calcification of its aortic wall portion, with perfectly functioning, pliable cusps without calcification or fibrous overgrowth up to 6 months. The pericardial valves (Pericarbon stentless) showed extensive fibrous sheathing, causing progressive retraction of the leaflets and severe regurgitation. After 3 months, minimal calcification was seen in the pericardial wall. Calcification was more pronounced after 6 months, sometimes causing complete calcification of pericardial wall and leaflets, leading to a significant stenosis. We conclude that the pericardial stentless valve becomes rapidly dysfunctional after right-sided implantation as a result of fibrous sheathing and severe calcification. The porcine aortic stentless valve remains functional, but severe calcification of the aortic wall portion is problematic.
Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy (2019)

The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. The first known ingestion of foods often causes allergic reaction, suggesting that sensitization of offspring with food allergens may occur during pregnancy and/or through breastfeeding. This creates a milieu that shapes the neonatal immune responses to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances from human data in our understanding of how maternal factors, namely, food allergens, allergen-specific immunoglobulins, cytokines, genetics, and environmental factors transferred during pregnancy or breastfeeding influence offspring allergies and how such effects may be applicable to food allergy. Based on information obtained from mouse models of asthma and food allergy, the review also dissects the mechanisms by which maternal factors, including the impact of immune complexes, transforming growth factor-β, vitamin A, and regulatory T-cell responses, contribute to the induction of neonatal tolerance vs. development of allergic responses to maternally transferred allergens.
Abstract 10390: Simvastatin Increases Irisin Concentrations in Human Subjects in Vivo and Irisin Expression and Secretion in Human Skeletal Muscle Cells ex Vivo (2013)

Introduction: Irisin is a muscle-tissue-secreted peptide, a myokine, is induced by exercise and can convert white fat into brown fat. Little is known about the association of irisin with metabolic ...
Stent-Graft Arteriovenous Fistula: An Endovascular Technique in Hemodialysis Access (1998)

Purpose: To determine the feasibility and safety of a new endovascular technique for creating an arteriovenous (AV) fistula utilizing catheter-directed techniques and stents. Methods: Stent-graft AV fistulas were offered on an experimental basis to 8 patients who had a history of multiple failed access procedures or very small arm veins unsuitable for standard vascular access techniques. The device consisted of a balloon-expandable Palmaz stent attached to the designated venous end of a polytetrafluoroethylene graft. The balloon-mounted stent-graft was inserted into the brachial vein through an arteriotomy and advanced over a guidewire into the axillary vein. After the stent-graft was deployed, the arterial anastomosis was completed in standard surgical fashion using an end-to-side anastomosis of the graft to the brachial artery. Results: The stent-graft was inserted successfully in all patients, but there were two early failures. The first resulted from a steal phenomenon secondary to high flows through the stent-graft, necessitating ligation of the fistula. Another stent-graft was placed too peripherally in the upper arm, and the stainless steel stent was crushed by external compression. Three of the 6 remaining grafts were patent for over 1 year, and 2 grafts are still functioning at 22 and 13 months. Conclusions: Endoluminal stent-grafts can be successfully inserted into the axillary vein for creation of an AV fistula and remain patent for 2 years or more. This method may be most useful in patients with very small, unusable arm veins or multiple failed AV grafts.
Understanding the performance of concurrent error detecting superscalar microarchitectures (2006)

Superscalar out-of-order micro architectures can be modified to support redundant execution of a program as two concurrent threads for soft-error detection. However, the extra workload from redundant execution incurs a performance penalty due to increased contention for resources throughout the datapath. We present four key parameters that affect performance of these designs, namely 1) issue and functional unit bandwidth, 2) issue queue and reorder buffer capacity, 3) decode and retirement bandwidth, and 4) coupling between redundant threads' instantaneous resource requirements. We then survey existing work in concurrent error detecting superscalar micro architectures and evaluate these proposals with respect to the four factors.
SU-FF-T-342: Peripheral Brachytherapy, Dosimetry, and Image Guidance Using the AccuBoost System (2007)

Purpose: The Advance Radiation Therapy AccuBoost® system applies peripheral breast brachytherapy using combinations of stereotactic, parallel-opposed HDR beams under mammographic image guidance. Dosimetric characterization and commissioning for clinical use are presented. Materials and Methods: The AccuBoost system delivers a conformal boost with the breast compressed to 3–7 cm thickness between two mammography paddles using 5, 6, or 7 cm diameter applicators. This compressed breast geometry was simulated using experimental techniques and Monte Carlo methods. Measurements were performed in a 30×30 cm2 polystyrene phantom using a calibrated parallel-plate ionization chamber positioned at depths of 0–7 cm along the central axis, and with either radiochromic film (GafChromic EBT) or computed radiography phosphor plate (Kodak Hres) placed parallel and normal to the phantom:applicator plane. The MCNP5 radiation transport code was used to simulate the HDR source, AccuBoost applicator, and compressed breast, assuming cylindrical symmetry. Dose was calculated with 1 mm resolution versus depth and radius for all breast thickness and applicator diameter combinations. Dosimetric results were reduced to a spreadsheet-based lookup table for clinical implementation. Additional experiments were performed using a mammography system (GE Senographe 800T) and a CIRS breast phantom (model 051) containing radio-opaque markers for image evaluation and marker localization. Results: Ionization chamber measurements and MC-derived dose falloff agreed within 2%. Film measurements and MC-derived relative dose profiles agreed within 6%. Skin/target dose ratio, for a dual axis exposure, varied from 0.5–1.1 over the wide range of applicator sizes and breast separations. Marker localization within 1 mm was achievable. Conclusions: The AccuBoost system can apply a conformal boost dose to the breast in a stereotactic configuration. The clinical environment may be readily simulated and treatment plans may be verified as evidenced by good agreement amongst the three dose measurement techniques. Disclosure: Research sponsored by Advanced Radiation Therapy.
Ruggedness of High-Voltage IGBTs and Protection Solutions (2013)

IGBTs are today’s most important power-semiconductor switches in the field of medium and high power ranges. The good controllability of this device with a voltage source is advantageous. The following work investigates the IGBT at short-circuit and surge-current condition. A particular focus is put on the IGBT’s feedback on the gate-control circuit. Special modes during the short circuit are measured and explained. For example the self-turn-off mechanism during short circuit and the collector-emitter voltage-clamping capability during fast short-circuit turn-off. Measurements are done at high-voltage IGBT chips and press-pack devices. The complete IGBT output characteristic up to the breakdown point is measured. Additionally, the short circuit is investigated at the parallel and series connection of IGBTs. Supporting semiconductor simulations of a high-voltage IGBT model, that was specially constructed for this work, analyse the internal behaviour during the mentioned conditions. The impact of different IGBT designs on the short-circuit ruggedness and breakdown behaviour is shown. Solutions for protecting the device from destruction during overload condition are presented. Measurements and simulations explain the surge-current capability of an IGBT and demonstrate the benefit for the application.
High spatial resolution thermal conductivity of bulk ZnO (0001) (2002)

We measured high spatial/depth resolution 300 K thermal conductivity κ of the Zn and O surfaces of two bulk n-type ZnO (0001) samples, grown by a vapor-phase transport method, using scanning thermal microscopy (SThM). The thermal investigation was performed in both point-by-point (∼2 μm resolution) and area-scan modes. On the first sample κ=1.16±0.08 (Zn face)/1.10±0.09 (O face) W/cm K while for the second material κ=1.02±0.07 (Zn face)/0.98±0.08 (O face) W/cm K. These are the highest κ values reported on ZnO. A correlation between SThM area-scan readings and surface topography was established by simultaneously performing atomic force microscopy scans. The influence of surface roughness on the effective thermal conductivity (i.e., heat flow) is discussed.
Positron emission tomography in a patient with progressive multifocal leukoencephalopathy (1988)

A 56-year-old man with chronic lymphocytic leukemia, progressive multifocal leukoencephalopathy, and a dense left homonymous hemianopia had 18F-fluorodeoxyglucose positron emission tomography. Cortical glucose metabolism was decreased in the right cerebral hemisphere and the left cerebellar hemisphere. To our knowledge, this is the first demonstration of cerebral and cerebellar hypometabolism due solely to white matter disease.
Simplified procedure for purification of Bordetella bronchiseptica dermonecrotic toxin (1990)

Bordetella bronchiseptica dermonecrotic toxin was purified by a simplified method. The method consisted of SP Toyopearl 650M chromatography and high performance liquid chromatography on a TSK gel G3000SW column. 47.5% of the activity of the crude cell extract was recovered. The purified toxin behaved as a homogeneous protein in sodium dodecyl sulfate polyacrylamide gel electrophoresis, high performance liquid chromatography, and agar gel double diffusion tests.
ChemInform Abstract: EFFICIENT SYNTHESIS OF 3‐FORMYL‐1,2,4‐TRIAZOLE NUCLEOSIDE USING DIETHOXYACETONITRILE AS A SYNTHON (1981)

Abstract Das aus Diethoxyacetonitril (I) gebildete Imidat (II) reagiert mit Formylhydrazin (III) zu einem Triazolylacetal (IV), aus dem durch Hydrolyse der Triazolaldehyd (V) gebildet wird.
Active Force Feedback in Real-life Industrial Robots (2004)

Active force feedback in robots has been developed in the 1970s as an answer to the limitations of the passive solutions, like the RCC (Remote Center Compliance), offered as an add-on for peg-into-hole assembly operations. Generic solutions of force feedback and impedance control have been developed in laboratory environments, but their industrial use has been very limited ever since. This situation has recently changed and it becomes feasible now to provide off-the-shelf industrial robots with real-time force feedback capabilities. In the paper, two convincing case-studies of tasks with force control will be presented. One is the synchronisation of a brake press with a plate-handling robot for sheet metal bending applications. Synchronisation is assured in two ways: (i) through a geometric bending model, and (ii) through active force feedback. The second case study deals with forcecontrolled assembly of rotary compressors. Here passive RCC-like aids are compared with force-feedback solutions. In some critical cases, active force feedback is the only solution, while in other cases passive aids suffice.
Gravity-Enhanced Transfer between Fracture and Matrix in Solvent-Based Enhanced Oil Recovery (2012)

Solvent injection has been considered as an efficient method for enhancing oil recovery from fractured reservoirs. The success of this method therefore depends on the degree of enhancement of the mass exchange rate between the solvent residing in the fracture and the oil residing in the matrix. If the mass transfer would be solely based on diffusion, oil recovery would be unacceptably slow. A series of soak experiments have been conducted to investigate the mass transfer rate between the fracture and the matrix. In a soak experiment, a porous medium containing oil is immersed in an open space containing the solvent to simulate the matrix and the fracture, respectively. We use a CT scanner to visualize the process. The experimental data are compared with a simulation model that takes diffusive and gravitational forces into account. We find that the initial stage of all experiments can be described by a diffusion-based model with an enhanced “effective diffusion coefficient”. In the second stage enhancement of the transfer rate occurs due to the natural convection of solvent in the fracture. The experiments are quantitatively modeled by numerical simulations. We find that transfer rates depend on the properties of the rock permeability, the viscosity and the density of solvent and oil. The gravity enhanced transfer is quantified by comparison of experimental and simulated results.
Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era (2023)

How to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 mutations at activation-induced cytidine deaminase (AICDA) sites, we examined 11 AICDA mutational targets, including BCL2, BCL6, PAX5, PIM1, RHOH, SOCS, and MYC, in 199 newly diagnosed grade 1 and 2 FLs. BCL2 mutations with VAF ≥20% occurred in 52% of cases. Among 97 FL patients who did not initially receive rituximab-containing therapy, nonsynonymous BCL2 mutations at VAF ≥20% were associated with increased transformation risk (HR 3.01, 95% CI 1.04-8.78, p = 0.043) and a trend toward shorter event-free survival (EFS, median 20 months with mutations versus 54 months without, p = 0.052). Other sequenced genes were less frequently mutated and did not increase the prognostic value of the panel. Across the entire population, nonsynonymous BCL2 mutations at VAF ≥20% were associated with decreased EFS (HR 1.55, 95% CI 1.02-2.35, p = 0.043 after correction for FLIPI and treatment) and decreased overall survival after median 14-year follow-up (HR 1.82, 95% CI 1.05-3.17, p = 0.034). Thus, high VAF nonsynonymous BCL2 mutations remain prognostic even in the chemoimmunotherapy era.
Methionine: a green and efficient promoter for copper‐catalyzed Sonogashira cross‐coupling reactions (2015)

In the presence of amino acids as environmentally friendly ligands, CuI‐catalyzed Sonogashira cross‐coupling of various aryl halides with phenylacetylene was conducted to afford the corresponding internal alkynes. l ‐Methionine was found to be useful for this palladium‐free and amine‐free coupling reaction. It was also found that the solvent system plays an important role in this reaction, and significantly affects the product formation and reaction rate. Sonogashira coupling of aryl iodides and aryl bromides in dimethylsulfoxide or dimethylformamide gave the coupled products in good to excellent yields. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Incorporating Interpersonal Synchronization Features for Automatic Emotion Recognition from Visual and Audio Data during Communication (2021)

During social interaction, humans recognize others' emotions via individual features and interpersonal features. However, most previous automatic emotion recognition techniques only used individual features-they have not tested the importance of interpersonal features. In the present study, we asked whether interpersonal features, especially time-lagged synchronization features, are beneficial to the performance of automatic emotion recognition techniques. We explored this question in the main experiment (speaker-dependent emotion recognition) and supplementary experiment (speaker-independent emotion recognition) by building an individual framework and interpersonal framework in visual, audio, and cross-modality, respectively. Our main experiment results showed that the interpersonal framework outperformed the individual framework in every modality. Our supplementary experiment showed-even for unknown communication pairs-that the interpersonal framework led to a better performance. Therefore, we concluded that interpersonal features are useful to boost the performance of automatic emotion recognition tasks. We hope to raise attention to interpersonal features in this study.
Modeling of fully printed organic field effect transistors for circuit design and simulation (2016)

Organic field effect transistors (OFETs) have significantly improved during recent years. However, there is still a lack of complete compact models for these devices, due to different materials, device structures, and manufacturing processes. Previous studies on compact OFET modeling have only considered static I-V characteristics, which are subject to the bias-stress effect. In this study, for the first time, two different large-signal OFET models are optimized to small-signal experimental data, which are less sensitive to the bias-stress effect. Li's and Estrada's models are studied overall I-V regions, from sub-threshold to above-threshold, and from linear to saturation region with unified formulations. It is found that Estrada's model fits better to the trans-conductance, whereas the Li's model fits better to the intrinsic gain. Both models are implemented in ADS circuit simulator, using the Verilog-A programming language. The bootstrapped amplifier is simulated and is compared with measurement data.
Superconducting properties of Y–Ba–Cu–O Compounds (1987)

Superconducting properties of Y–Ba–Cu–O compounds have been studied by resistivity, current-voltage characteristics, ac susceptibility, x-ray diffraction, and reverse ac Josephson effect measurements. The results are described in terms of granular superconductivity with the Josephson coupling depending upon composition and annealing conditions. In several mixed phase compounds, the presence of Josephson coupled grains have been detected at 240 K by the reverse ac Josephson effect.
Migration and Instantaneous Phase Combination to Detect Hidden Culverts Characteristics in GPR Data (2010)

Ground Penetrating Radar (GPR) is a nondestructive testing method used to test the quality of roads, pavements, bridges and buildings. GPR uses high frequency electromagnetic waves at the Microwave or Radio Frequency range to investigate the subsurface. It is used to measure features such as pavement layer thickness, moisture content, horizontal cracks, and voids. The electromagnetic waves reflected from the interfaces in the subsurface are used to analyze the structure of the area under scan. This paper presents two processing methods in hide culverts detection in roads structure that complete each other successfully. At first, we applied Migration method to remove hyperbolas and then by instantaneous phase method, we determined the top depths of culverts on a GPR data that has been collected from a culvert with known characteristics. The results corresponded to visible parameters truly. Then these methods applied on a hide culvert data on a road in Fars providence, Iran. The results satisfied with existed documents of this culvert&apos;s construction. The results of the study will be presented in the paper.