gebhart/patrepeval huggingface dataset:
A Phase I, Multi-Dose, Dose Escalation Study of SGN-40 (anti-huCD40 mAb) in Patients with Refractory or Recurrent Multiple Myeloma. (2004)

Abstract CD40 is a type I transmembrane protein that upon binding to CD40 ligand regulates important biologic effects in the immune system. CD40 is also highly expressed on hematologic tumors, which has raised interest in the potential for its use as a tumor target for antibody-based cancer therapy. SGN-40 is a humanized monoclonal antibody that selectively binds to human CD40 and induces apoptosis and growth inhibition of a wide variety of B-cell derived cancer cell lines in vitro. Our preclinical work has confirmed the in vitro cytotoxicity of SGN-40 against human multiple myeloma (MM) cells via several mechanisms. These include induction of cytotoxic ligands of TNF superfamily; suppression of IL-6-induced proliferative and anti-apoptotic effects, as well as antibody-dependent cell-mediated cytotoxicity (Tai, et al, Cancer Research64, 2846–2852, April 15, 2004). Since ≥ 90% of MM cells express CD40, targeting CD40 using SGN-40 presents a potential novel treatment strategy. Based on these preclinical data, a phase I study is being conducted to define the toxicity profile, characterize the pharmacokinetics (PK), and evaluate antitumor effects of SGN-40 in patients with refractory or recurrent MM. Four weekly doses ranging from 0.5 to 16 mg/kg are planned to be administered to groups of at least three patients per cohort. Patients will be followed for up to 6 weeks post their last dose. Currently, a total of seven patients have been treated with SGN-40 at dose levels of 0.5 and 1.0 mg/kg. No grade 3 or 4 non-hematologic dose limiting toxicities have been observed. One patient experienced a transient Grade 3 decrease in hemoglobin. Decrease in CD19 positive B-cells were noted for patients treated at both dose levels. Changes in serum and urine M protein levels were measured to estimate potential anti-tumor effects of SGN-40. Of the seven patients evaluated, one patient at 0.5 mg/kg dose had stable disease, based on serum M protein, over the 10 week study period. Clinical evaluation with dose escalation of this agent continues and updated safety, PK and antitumor data will be presented.
Intracellular pH and free calcium variations in skeletal muscle cells under chemical hypoxia (1995)

International audience
Intramedullary Fixation of Tibial Shaft Fractures Using an Expandable Nail: Early Results of 54 Acute Tibial Shaft Fractures (2006)

The expandable nail offers the theoretical advantages of improved load sharing and rotational control without the need for interlocking screws. This study demonstrates satisfactory healing and alignment for the treatment of tibial shaft fractures using this device. However, caution must be exercised when using this nail in cases of significant comminution and in cases where the fracture pattern involves the more proximal or distal aspect of the tibial shaft.
Three-Dimensional Analysis of Molecular Signals with Episcopic Imaging Techniques (2008)

This chapter describes two episcopic imaging methods, episcopic fluorescence image capturing (EFIC) and high-resolution episcopic microscopy (HREM). These allow analysis of molecular signals in a wide variety of biological samples such as tissues or embryos, in their precise anatomical and histological context. Both methods are designed to work with histologically prepared and whole-mount stained material, and both provide high-resolution data sets that lend themselves to 3D visualization and modeling. Specimens are embedded in wax (EFIC) or resin (HREM) and sectioned on a microtome. During the sectioning process, a series of digital images of each freshly cut block surface is captured, using a microscope and CCD camera aligned with the position at which the microtome block holder comes to rest after each cutting cycle. The resulting stacks of serial images retain virtually exact alignment and are readily converted to volume data sets. The two methods differ in how tissue architecture is visualized and hence how specific molecular signals are detected. EFIC uses endogenous, broad-range, tissue autofluorescence to reveal specimen structure. Addition of dyes to the wax embedding medium suppresses detection of any signal except that originating from the block surface. EFIC can be used to detect specific signals (such as LacZ) by virtue of their ability to suppress such fluorescence. In contrast, the plastic embedding medium used in HREM is strongly fluorescent, and tissue architecture is detected at the surface because of the ability of cellular and subcellular structures to suppress this signal. Specific signals generated as a result of chromogenic reactions can be visualized using band-pass filters that suppress the appearance of morphological data. In both methods, the digital volume data show high contrast; for HREM, such data achieve true cellular resolution. Their intrinsic alignment greatly facilitates their use for 3D analysis of transgene activity that can be visualized in the context of complex cellular and tissue morphology. Both methods are relatively simple and can be set up using common laboratory apparatuses. Together, they provide powerful tools for analyzing gene function in embryogenesis or tissue remodeling and for investigating developmental malformations.
Reflectarray Antenna at Terahertz Using Graphene (2013)

The use of graphene for fixed-beam reflectarray antennas at Terahertz (THz) is proposed. Graphene's unique electronic band structure leads to a complex surface conductivity at THz frequencies, which allows the propagation of very slow plasmonic modes. This leads to a drastic reduction of the electrical size of the array unit cell and thereby good array performance. The proposed reflectarray has been designed at 1.3 THz and comprises more than 25000 elements of size about λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /16. The array reflective unit cell is analyzed using a full vectorial approach, taking into account the variation of the angle of incidence and assuming local periodicity. Good performance is obtained in terms of bandwidth, cross-polar, and grating lobes suppression, proving the feasibility of graphene-based reflectarrays and other similar spatially fed structures at Terahertz frequencies. This result is also a first important step toward reconfigurable THz reflectarrays using graphene electric field effect.
A tool for fast indexing and querying of graphs (2011)

We present a tool called GiS for indexing and querying a large database of labeled, undirected graphs. Such graphs can model chemical compounds, represent contact maps constructed from 3D structure of proteins, and so forth. GiS supports exact subgraph matching and approximate graph matching queries. It adopts a suite of new techniques and algorithms for (a) fast construction of disk-based indexes with small index sizes, and (b) efficient query processing with high precision of matching. During the demo, the user can index real graph datasets using a recommendation facility in GiS, pose exact subgraph matching and approximate graph matching queries, and view matching graphs using the Jmol browser.
Theory of high-resolution mass spectrometry achieved via resonance ejection in the quadrupole ion trap (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheory of high-resolution mass spectrometry achieved via resonance ejection in the quadrupole ion trapDouglas E. Goeringer, William B. Whitten, J. Michael. Ramsey, Scott A. McLuckey, and Gary L. GlishCite this: Anal. Chem. 1992, 64, 13, 1434–1439Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ac00037a023https://doi.org/10.1021/ac00037a023research-articleACS PublicationsRequest reuse permissionsArticle Views905Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Loading Effects on the Attenuation of the Transferred Transients Through Cable Winding Transformer (Dryformer). (2003)

Abstract – Recently, dry power transformer (Dryformer) that performs one step transformation from transmission to distribution voltage levels, has been introduced [1]. The Dryformer (dry power transformer) combines the features of power transformer with that of station distribution transformer, by utilising XLPE insulated round conductor cable for winding construction. The parameters of the cable winding can be determined in the same way as for single core transmission cable, however, the influence of mutual inductance in the windings makes the transient propagation slower in the windings, than in corresponding transmission cable of the same size and length. Therefore it is important to have a better understanding of Dryformer behaviour with respect to transient surge voltage transfer under various loading conditions. The model for the Dryformer is derived earlier [2] based on
Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer (2018)

Article published in Acta Pharmaceutica Sinica B available open access at https://doi.org/10.1016/j.apsb.2018.12.007
<title>Closely supervised control of a target-steered UAV</title> (1999)

Orientation of a camera onboard an uninhabited aerial vehicle (UAV) that is used for reconnaissance is performed manually by an operator using a two degree-of-freedom joystick that commands camera azimuth and elevation. The flight path of the UAV is accomplished autonomously by an autopilot that transforms camera orientation into guidance commands that cause the UAV to fly to a destination, loiter or track a target as instructed by the operator. This control mode permits single-person operation of the UAV mission. In a manual mode, the aircraft circles the target at a fixed standoff distance from the UAV that is determined by instantaneous camera orientation and if available, ranging information to the target. The operator must continually track the target in this mode. In a shared control mode, the target location in an earth-fixed frame is determined from the camera orientation at a single point in time, in conjunction with the concurrent UAV position, the latter assumed to be available from GPS or an onboard inertial guidance system. This leaves the operator free to pan for other targets or perform other tasks. He can update target location or switch between the manual and shared modes at any time. This method also provides the added benefit that if the feed from the remote operator is lost, the aircraft will continue on its current heading or loiter smaller to current UAV operation. This teleoperation concept is being validated in Wright State University's CAVE automated virtual environment located at Wright Patterson Air Force Base.
Two Useful Directing Modes in Singlet Oxygen Reactivity: Electrostatic Effects in the Ene Reaction with Allylic Alcoholates and a Chemoselectivity Change with α‐Alkoxy Michael Esters (2018)

Abstract The front cover artwork is provided by Axel Griesbeck and Diana But at the University of Cologne (Germany). The image shows a cartoon of the hydrogen‐transfer process initiating the singlet oxygen ene reaction with several strong regio‐ and stereodirecting effects following the rule of thumb: If you give singlet oxygen your little finger it will soon have your whole hand (as adapted from a quote by Sigmund Freud). Read the full text of the Article at 10.1002/cptc.201800133 .
EFFECT OF IRON ON FLUORESCENCE IN GLASS* (1946)

ABSTRACT The mechanism of fluorescence as it occurs in a uranium glass when irradiated with ultraviolet light is discussed with special reference to factors affecting both the intensity and spectral distribution of the fluorescence. The destructive effect of iron on the fluorescence of the glass is discussed and is illustrated by spectral absorption curves and by recorded fluorescence spectra. Conclusions based on these data indicate that iron not only absorbs a large portion of the exciting radiation, thereby decreasing the fluorescence emission, but also re‐emits this absorbed radiation in the infrared, thus bringing about the infrared quenching of the fluorescence. Iron also causes an electrical disturbance around the fluorescing centers and is apparently capable of preventing the absorption of exciting radiation by these centers, further decreasing the intensity of fluorescence. A slight shift of the fluorescence spectrum toward shorter wave lengths is brought about by the presence of iron and is evidence of a weakening of the binding forces within the glass.
Progress Report of the Advanced Television Systems Committee (2017)

The Advanced Television Systems Committee (ATSC) is an international, nonprofit organization developing voluntary standards for digital television (DTV). The ATSC member organizations represent the broadcast, broadcast equipment, motion picture, consumer electronics, computer, cable, satellite, and semiconductor industries. ATSC is focused on the development of standards for terrestrial broadcast and hybrid broadcast/broadband television. This work includes both near-term, backward-compatible projects and long-term, nonbackward-compatible projects. SMPTE is a founding member of ATSC, which this year observes its 33th year of operation.
Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential (2016)

Lophatheri Herba (LH), dried leaf of Lophatherum gracile Brongn, has long been used to reduce thirst and treat fever and inflammation in Chinese medicine. Recent studies have shown that LH has anti-viral, anti-bacterial, anti-cancer, anti-oxidant, diuretic, and hyperglycemic properties. However, the effects of an ethanol extract of L. herba (ELH), at non-cytotoxic doses, on the metastatic and angiogenic abilities of malignant tumor cells have not been reported. We found that ELH significantly suppressed p38, JNK, and NF-κB activation and proteolytic activities under phorbol 12-myristate 13-acetate (PMA) stimulation, thus leading to a decrease in metastatic potential, including migration and invasion. In addition, ELH suppressed tumor-induced angiogenesis, including migration and tube formation in human umbilical vein endothelial cells (HUVECs) and microvessel sprouting from aortic rings via decreasing the pro-angiogenic factors in tumors. Interestingly, in ovo xenografts ELH-treated HT1080 cells did not increase in volume and eventually disappeared, owing to a lack of angiogenesis. Daily oral administration of ELH at 50 and 100 mg/kg markedly inhibited metastatic colonization of B16F10 cells in the lungs of C57BL/6J mice and caused no apparent side effects. These data collectively indicate that ELH is safe and may be useful for managing metastasis and growth of malignant cancers.
Bisulfite-free analysis of 5MeC-binding proteins and locus-specific methylation density using a microparticle-based flow cytometry assay (2010)

DNA methylation analysis is emerging as a new technique with potential capabilities for early cancer detection. However, current state-of-the-art techniques are not easily translatable into routine clinical methods. Herein we describe a bead-based flow cytometry assay which combines DNA hybridization to microparticles with 5MeC-specific proteins/antibodies. These assays can be used to study the binding properties of current and emerging 5MeC-binding proteins and may also have potential in the measurement of 5MeC density in clinical samples for cancer detection.
Chalktalk : A Visualization and Communication Language -- As a Tool in the Domain of Computer Science Education (2018)

In the context of a classroom lesson, concepts must be visualized and organized in many ways depending on the needs of the teacher and students. Traditional presentation media such as the blackboard or electronic whiteboard allow for static hand-drawn images, and slideshow software may be used to generate linear sequences of text and pre-animated images. However, none of these media support the creation of dynamic visualizations that can be manipulated, combined, or re-animated in real-time, and so demonstrating new concepts or adapting to changes in the requirements of a presentation is a challenge. Thus, we propose Chalktalk as a solution. Chalktalk is an open-source presentation and visualization tool in which the user's drawings are recognized as animated and interactive "sketches," which the user controls via mouse gestures. Sketches help users demonstrate and experiment with complex ideas (e.g. computer graphics, procedural animation, logic) during a live presentation without needing to create and structure all content ahead of time. Because sketches can interoperate and be programmed to represent underlying data in multiple ways, Chalktalk presents the opportunity to visualize key concepts in computer science: especially data structures, whose data and form change over time due to the variety of interactions within a computer system. To show Chalktalk's capabilities, we have prototyped sketch implementations for binary search tree (BST) and stack (LIFO) data structures, which take advantage of sketches' ability to interact and change at run-time. We discuss these prototypes and conclude with considerations for future research using the Chalktalk platform.
Future Trends (2022)

No AccessRecycling of PlasticsOct 2022Future TrendsHolger Ruckdäschel and Tobias StandauHolger RuckdäschelSearch for more papers by this author and Tobias StandauSearch for more papers by this authorhttps://doi.org/10.3139/9781569908570.018SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 785-802Print ISBN: 978-1-56990-856-3eISBN: 978-1-56990-857-0 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A Simple Synthesis of β-Alkyl-Substituted β-Amino Acids (1998)

Abstract By the condensation of branched-chain aliphatic or alicyclic aldehydes with malonic acid in the presence of ammonium acetate, β-alkyl-substituted β-amino acids were prepared.
Characterization of an Integrable Single-Crystalline 3-D Tactile Sensor (2006)

Porous-Si-micromachining technique was used for the formation of single-crystalline force-sensor elements, capable of resolving the three vector components of the loading force. Similar structures presented so far are created from deposited polycrystalline Si resistors embedded in multilayered <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$hboxSiO_2/hboxSi_3hboxN_4$</tex> membranes, using surface micromachining technique for a cavity formation. In this paper, the authors implanted four piezoresistors in an n-type-perforated membrane, having their reference pairs on the substrate in order to form four half bridges for the transduction of the mechanical stress. They successfully combined the HF-based porous-Si process with conventional doping and Al metallization, thereby offering the possibility of integration with readout and amplifying electronics. The <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$300 times 300 muhboxm^2$</tex> membrane size allows for the formation of large tactile arrays using single-crystalline-sensing elements of superior mechanical properties. They used the finite-element method for modeling the stress distribution in the sensor, and verified the results with real measurements. Finally, they covered the sensors with different elastic silicon–rubber layers, and measured the sensor's altered properties. They used continuum mechanics to describe the behavior of the rubber layer.
Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin- induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation (1992)

Abstract We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Because we also showed that TNF-alpha and IL-1 beta can act synergistically to cause monocytoid differentiation of HL-60 cells, we hypothesized that acivicin-induced TNF-alpha and IL-1 beta, in an autocrine manner, caused the differentiation. The purpose of the present study was to determine the causal roles of TNF-alpha and IL-1 beta in the acivicin-induced differentiation of HL-60 cells by the use of dexamethasone (DEX) and pentoxifylline (PTX), two drugs that effectively inhibit expression of TNF-alpha and IL-1 beta. Acivicin caused a monocytoid differentiation of the cells as manifest by diminished cell growth, morphologic maturation of the cells, increased ability to generate hydrogen peroxide in response to acute treatment with phorbol myristate acetate, and increased expression of nonspecific esterase and the surface antigens CD14 and CD11b. Acivicin treatment also caused the cells to have diminished steady-state expression of messenger RNA (mRNA) for c-myc and c-myb, and increased expression of mRNA for TNF-alpha and IL-1 beta. DEX and PTX did not alter cell growth, and did not block the acivicin-induced block in growth. PTX caused a slight increase in nonspecific esterase expression, but DEX had no effect on this, and neither drug diminished the acivicin-induced increase in nonspecific esterase. Although neither drug alone lessened the acivicin enhancement of hydrogen peroxide production, DEX and PTX together reduced this. DEX did not modify the acivicin-induced morphologic maturation of the cells, but PTX alone or PTX with DEX potentiated the acivicin-induced increase in mature cells. Basal CD14 and CD11b expression were slightly reduced by DEX and PTX, but neither drug modified the acivicin-induced increases. DEX and PTX reduced the acivicin-induced increases in TNF-alpha and IL-1 beta mRNA expression, but they had little or no effect on the acivicin-induced decreases in expression of mRNA for c-myc and c-myb. Thus, DEX and PTX effectively block the acivicin-induced expression of TNF-alpha and IL-1 beta, but they have little influence on the acivicin-induced differentiation process.(ABSTRACT TRUNCATED AT 250 WORDS)