gebhart/patrepeval huggingface dataset:
Key management and secure software updates in wireless process control environments (2008)

Process control systems using wireless sensor nodes are large and complex environments built to last for a long time. Cryptographic keys are typically preloaded in the wireless nodes prior to deployment and used for the rest of their lifetime. To reduce the risk of successful cryptanalysis, new keys must be established (rekeying). We have designed a rekeying scheme that provides both backward and forward secrecy.
Automated CFD Analysis Within the Preliminary Combustor Design System PRECODES Utilizing Improved Cooling Models (2007)

The design of state-of-the-art combustion chambers is based on a multitude of design rules. To use this knowledge more effectively and to accelerate the combustor design process an automated combustion chamber design tool is being developed within the European project INTELLECT D.M. (Integrated Lean Low Emission Combustor Design Methodology). Due to the automation of the design process the time required to set up a new preliminary combustion chamber design is reduced from weeks to hours. The development of the automated preliminary combustor design tool is described in [1]. The focus of this paper is on new developments of the design system PRECODES (preliminary combustor design system) including automated mesh generation and CFD simulation. Design rules and parameters are formalized and stored within an EXCEL database. The combustor layout process including the calculations of cooling air mass flows and the zonal layout is done automatically using this database. The layout process has to be iteratively adjusted in order to find an optimal design due to the nonlinear interdependence of some of the design variables. The EXCEL database provides information for two parametric CAD models. The first parametric model includes the flame tube, pre-diffuser, cowl, metering panel, heatshield and the casing. Therefore it is relatively complex and only used for weight approximation and visualization purposes. The second CAD model is a generic model of the flame tube providing the basis for the automatic CFD mesh generation and CFD simulations. The CAD geometry is transferred to the commercial grid generator ICEM-CFD via the ICEM internal direct CAD interface. Based on the CAD geometry a multiblock structured mesh is generated automatically. Due to the utilization of the same blocking master model for different flame tubes varying in combustor size and orientation, and size and position of the mixing holes the mesh topology differs only marginally between different designs. Thus the CFD simulations are well comparable. Different combustor configurations are generated based on input parameter changes, i.e. changing the pressure level, the zonal stoichiometry or the maximum allowable material temperatures. An overview of the present results and the potentials of applying the automated combustor design tool PRECODES is presented.
The prevalence of self-reported peptic ulcer in the United States. (1996)

The age-related rise and socioeconomic gradients of peptic ulcer represent the historic scars of previous infection rates with Helicobacter pylori. The racial variations reflect different ages at the time of first infection; younger and older age at the acquisition of H. pylori appear to be associated with gastric and duodenal ulcer, respectively.
A 65nm CMOS 2.4 GHz Phase Shifter based Direct Digital Synthesizer (2012)

This paper presents a 2.4 GHz Direct Digital Synthesizer (DDS) based on a 500 MHz Phase Shifter DDS and an Injection Locked Oscillator-(ILO) based frequency multiplier. The synthesizer output frequency is ranging from 2GHz to 2.5GHz. The frequency step is 300 Hz, and the measured SFDR is -65 dBc. Bluetooth modulation has been successfully demonstrated. Power consumption is 48 mW under a 1.2 V power supply.
A theory of sedimentation (1952)

The first page of this article is displayed as the abstract.
Polysiloxanes having aromatic heterocyclic units. I. Polydimethylsiloxane benzimidazole polymer (1969)

Abstract A polymer containing dimethylsiloxane units (35) and benzimidazole units (1) has been prepared by the condensation of 3,3′‐diaminobenzidine and an α,ω‐bis‐(γ‐carboxy‐ n ‐propyl) polydimethylsiloxane. The new polymer has some rubbery properties, but it decomposes catastrophically at 400°C.
β-carotene and vitamins C and E did not reduce the occurrence of colorectal adenomas (1994)

Source Citation Greenberg ER, Baron JA, Tosteson TD, et al. for the Polyp Prevention Study Group. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med. 1994 Jul 21;3...
HumanEscherichia coliO157:H7 Genetic Marker in Isolates of Bovine Origin (2004)

The antiterminator Q gene of bacteriophage 933W (Q933) was identified upstream of the stx2 gene in 90% of human disease-origin Escherichia coli O157:H7 isolates and in 44.5% of bovine isolates. Shiga toxin production was higher in Q933-positive isolates than Q933-negative isolates. This genetic marker may provide a useful molecular tool for epidemiologic studies.
Modification of Electrical and Mechanical Properties of Selective Laser‐Melted CuCr0.3 Alloy Using Carbon Nanoparticles (2019)

Herein, the influence of carbon nanoparticle addition on the selective laser melting (SLM) behavior and the resultant properties of gas‐atomized CuCr0.3 powder are investigated. The carbon addition neither affects the powder flowability, nor its packing density, but it significantly enhances the optical absorption for infrared radiation. Despite the improved optical absorption of the powder bed after carbon addition, a comparable SLM behavior is observed for both virgin and carbon‐mixed CuCr0.3 powders. Furthermore, the addition of carbon nanoparticles facilitates in situ deoxidation of copper and chromium oxides present in the CuCr0.3 powder. Accordingly, a larger fraction of chromium is obtained in its metallic form in the as‐built carbon‐mixed CuCr0.3 part. The presence of metallic chromium allows tailoring of the mechanical and electrical properties by postheat treatments (HTs). The best combination of mechanical (tensile strength of 298 ± 19 MPa, yield strength of 208 ± 18 MPa, ductility of 21 ± 4%) and electrical (87 ± 1% international annealed copper standards [% IACS]) properties is realized for the carbon‐mixed CuCr0.3 alloy after a direct age hardening HT. The improvement in mechanical properties is attributed to the precipitation of nanometer‐sized, coherent, and metallic chromium precipitates in the copper matrix.
Optimized geometry compression for real-time rendering (1997)

Most existing visualization applications use 3D geometry as their basic rendering primitive. As users demand more complex data sets, the memory requirements for retrieving and storing large 3D models are becoming excessive. In addition, the current 3D rendering hardware is facing a large memory bus bandwidth bottleneck at the processor to graphics pipeline interface. Rendering 1 million triangles with 24 bytes per triangle at 30 Hz requires as much as 720 MB/sec memory bus bandwidth. This transfer rate is well beyond the current low-cost graphics systems. A solution is to compress the static 3D geometry as an off-line pre-process. Then, only the compressed geometry needs to be stored in main memory and sent down to the graphics pipeline for real-time decompression and rendering. The author presents several new techniques for compression of 3D geometry that produce 2 to 3 times better compression ratios than existing methods. They first introduce several algorithms for the efficient encoding of the original geometry as generalized triangle meshes. This encoding allows most of the mesh vertices to be reused when forming new triangles. Their second contribution allows various parts of a geometric model to be compressed with different precision depending on the level of details present. Together, the meshifying algorithms and the variable compression method achieve compression ratios of 30 and 37 to one over ASCII encoded formats and 10 and 15 to one over binary encoded triangle strips. The experimental results show a dramatically lowered memory bandwidth required for real-time visualization of complex data sets.
Phase I/II study of everolimus (E) with irinotecan (Iri) and cetuximab (C) in 2nd line metastatic colorectal cancer (mCRC): Hoosier Cancer Research Network GI05-102. (2015)

3618 Background: Preclinically, mTOR and EGFR inhibitors are synergistic. We hypothesized that the mTOR inhibitor E would enhance clinical efficacy when added to C. The Phase I portion determined the safety, and maximum tolerated dose (MTD), and the Phase II evaluated the response and survival rates with this combination. Preliminary results of the Phase I study (ASCO 2011, Shahda et al) determined the MTD as E 5 mg po daily (qd) combined with Iri and C. Here we report overall safety and efficacy results of the Phase I/II study. Methods: Patients (pts) were treated with Iri 125 mg/m2 weekly (qw) x 2 every 3 wks, C 400 mg/m2 loading, then 250 mg/m2 qw, and escalating doses of E: 5 mg qod, 5 mg qd and 10 mg qd in 21-day cycles (Phase I), and 5 mg qd (Phase II). Eligibility allowed KRAS mutated (MUT) mCRC. During phase II, KRAS wild-type (WT) pts were randomized to Iri+C+E vs Iri+C, and all KRAS MUT pts received Iri+C+E. Archival tumors were analyzed for biomarkers of EGFR and mTOR pathways activation. The study was discontinued early due to funding termination by Novartis. Results: 43 pts were enrolled, median age 60 y (25-77), 24 male. 30 pts enrolled in phase I (KRAS WT n = 15, KRAS MUT n = 13, KRAS unknown n = 2), and 13 pts in phase II (KRAS WT: n = 5 Iri+C+E, n = 2 Iri+C; KRAS MUT n = 6 Iri+C+E). The most common gr 3/4 AEs were diarrhea (35%), neutropenia (23%), fatigue (21%), mucositis (21%), and rash (19%). Among KRAS WT pts (n = 22) there were 1 CR, 3 PR (RR 18%), 12 SD (54%), and among KRAS MUT pts (n = 19) there were 1 PR (5%) and 11SD (52%). Median progression-free survival (PFS) and overall survival (OS) rates were 6 and 16 mos, respectively for all KRAS WT pts treated with Iri+C+E (n = 20), and 8.3 and 21.6 mos, respectively for KRAS WT pts treated at MTD (n = 11). Median PFS and OS were 4.3 and 12.3 mos, respectively for KRAS MUT pts. Only 2 KRAS WT pts were randomized to Iri+C before study closure. PD markers will be presented. Conclusions: The combination of Iri+C+E has an expected toxicity profile, and was clinically active as second-line treatment for KRAS WT mCRC pts. Further studies should assess the CRC pts most likely to benefit from mTOR inhibitors in addition to EGFR blockade. (NCT00522665) Clinical trial information: NCT00522665.
miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14 (2016)

Matrix metalloproteinase 14 (MMP-14), a membrane-anchored MMP that promotes the tumorigenesis and aggressiveness, is highly expressed in gastric cancer. However, the transcriptional regulators of MMP-14 expression in gastric cancer still remain largely unknown. In this study, through mining computational algorithm programs and chromatin immunoprecipitation datasets, we identified adjacent binding sites of myeloid zinc finger 1 (MZF1) and miRNA-337-3p (miR-337-3p) within the MMP-14 promoter. We demonstrated that MZF1 directly bound to the MMP-14 promoter to facilitate its nascent transcription and expression in gastric cancer cell lines. In contrast, endogenous miR-337-3p suppressed the MMP-14 expression through recognizing its binding site within MMP-14 promoter. Mechanistically, miR-337-3p repressed the binding of MZF1 to MMP-14 promoter via recruiting Argonaute 2 and inducing repressive chromatin remodeling. Gain- and loss-of-function studies demonstrated that miR-337-3p suppressed the growth, invasion, metastasis, and angiogenesis of gastric cancer cells in vitro and in vivo through repressing MZF1-facilitated MMP-14 expression. In clinical specimens and cell lines of gastric cancer, MZF1 was highly expressed and positively correlated with MMP-14 expression. Meanwhile, miR-337-3p was under-expressed and inversely correlated with MMP-14 levels. miR-337-3p was an independent prognostic factor for favorable outcome of gastric cancer, and patients with high MZF1 or MMP-14 expression had lower survival probability. Taken together, these data indicate that miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer.
Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype. (1993)

The STE3 gene of Saccharomyces cerevisiae encodes a G protein-coupled receptor that is specific for the mating pheromone a-factor. The ste3L194Q mutation, which leads to the substitution of glutamine for leucine-194 within the third cytoplasmic loop of the receptor, resulted in a 20-fold increase in pheromone sensitivity and also caused partial constitutive activation of the response pathway. Moreover, other amino acid substitutions at the 194 position and several deletion mutations that collectively remove most of the third cytoplasmic loop resulted in hyperactive receptors. Therefore, we suggest that one role of the third cytoplasmic loop is to function as a negative regulatory domain involved in the maintenance of a nonsignaling state of the receptor. The constitutive activity and the pheromone hypersensitivity of ste3L194Q cells were recessive, suggesting that the wild-type receptor can antagonize the signal associated with the activated receptor. The ste3 delta 306 mutation, which results in truncation of most of the C-terminal domain of the receptor, led to a 20-fold increase in pheromone sensitivity, indicating that this domain also mediates negative regulation of the receptor. The ste3L194Q and ste3 delta 306 mutations appear to affect receptor activity independently, because the double mutant was associated with a 400-fold increase in pheromone sensitivity.
High-throughput Workflow for Glycan Profiling and Characterisation (2014)

Over the last 40 years, the understanding of glycosylation changes in health and disease has evolved significantly and glycans are now regarded as excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of clinical glycobiomarkers has been slow, mainly as a consequence of the lack of high-throughput glycoanalytical workflows that allow rapid glycoprofiling of large clinical sample sets. To generate high-quality quantitative glycomics data in a high-throughput fashion, we have developed a robotised platform for rapid N-glycan sample preparation and glycan characterisation. The sample preparation workflow features a fully automated, rapid glycoprotein affinity purification followed by sequential protein denaturation and enzymatic glycan release on a multiwell ultrafiltration device, thus greatly streamlining all required biochemical manipulations. After glycan purification on solidsupported hydrazide, glycans are fluorescently labelled to allow accurate quantification by ultra-high pressure liquid chromatography (ultra HPLC or UPLC). Subsequent peak assignment can be carried out utilising GlycoBase, a bespoke chromatographic data system developed to aid the analysis of glycans performed using different chromatographic techniques (UPLC, HPLC, Reverse Phase-UPLC, Capillary Electrophoresis).
Effective outer scale estimation for Euro50 site (2003)

Modeling the performance of future ground-based extremely large telescopes with the AO system requires an atmospheric model and a corrective algorithm. The atmospheric model employed here is the ORM 7 layer model with an outer scale distribution. Using an analytical algorithm for atmospheric correction the performance of the Euro50 telescope is analyzed. The influence of a distributed outer scale on the strokes of the adaptive mirrors is investigated. It is concluded that for modeling the AO system performance the account for variations of outer scale with altitude is of not great importance, and a simplified atmospheric model with the effective outer scale common for all layers may be used. The knowledge of effective outer scale is sufficient for setting requirements on the mirror strokes.
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes (2006)

The SWIRM domain is a module found in the Swi3 and Rsc8 subunits of SWI/SNF-family chromatin remodeling complexes, and the Ada2 and BHC110/LSD1 subunits of chromatin modification complexes. Here we report the high-resolution crystal structure of the SWIRM domain from Swi3 and characterize the in vitro and in vivo function of the SWIRM domains from Saccharomyces cerevisiae Swi3 and Rsc8. The Swi3 SWIRM forms a four-helix bundle containing a pseudo 2-fold axis and a helix-turn-helix motif commonly found in DNA-binding proteins. We show that the Swi3 SWIRM binds free DNA and mononucleosomes with high and comparable affinity and that a subset of Swi3 substitution mutants that display growth defects in vivo also show impaired DNA-binding activity in vitro, consistent with a nucleosome targeting function of this domain. Genetic and biochemical studies also reveal that the Rsc8 and Swi3 SWIRM domains are essential for the proper assembly and in vivo functions of their respective complexes. Together, these studies identify the SWIRM domain as an essential multifunctional module for the regulation of gene expression.
Development of 3D Parametric Models for Modular Bridge Substructures (2012)

Received August 3, 2012 / Accepted September 15, 2012ABSTRACT: Modular bridge construction enabling better productivity of design and construction by standardized members and robotic construction becomes an important issue in construction industry. Modular structures needs accurate information delivery between design, fabrication and construction processes. BIM (Building Information Modeling) based parametric modeling was propo sed for the modular bridge substructure. Considering ranges of parameters of the modular bridge, fixed value, variables and relations were defined and these parametric models were applied to design, analysis and fabrication. Experience from development of new structures can be embedded in the 3D models, and the models provide efficient and precise knowledge delivery. KEYWORDS: Modular bridge, Substructure, Parametric modeling, Information delivery요 약 : 부재를 표준화하여 설계 및 제작 생산성을 높이고 기계화 시공을 가능하게 하는 모듈러 교량이 건설 산업에서 중요하게 대두되고 있다. 반복성이 높고 설계, 제작 시공 과정에서의 정보의 원활한 전달이 필요하기 때문에 BIM(Building Information Modeling) 기술에 기반한 변수 모델링 정의를 제시하였다. 모듈러 교량이 갖는 변수 범위를 고려하여 고정변수, 변동변수, 연관변수로 구분하여 정의하고 이를 설계, 해석, 제작에 활용할 수 있도록 하였다. 구조시스템 개발과정의 지식을 정보화하여 3차원 모델의 정확성과 활용성을 높였다.키워드: 모듈러 교량, 하부구조, 변수모델링, 정보전달
PCOT: Cache Oblivious Tiling of Polyhedral Programs (2018)

This paper studies two variants of tiling: iteration space tiling (or loop blocking) and cache-oblivious methods that recursively split the iteration space with divide-and-conquer. The key question to answer is when we should be using one over the other. The answer to this question is complicated for modern architecture due to a number of reasons. In this paper, we present a detailed empirical study to answer this question for a range of kernels that fit the polyhedral model. Our study is based on a generalized cache oblivious code generator that support this class, which is a superset of those supported by existing tools. The conclusion is that cache oblivious code is most useful when the aim is to have reduced off-chip memory accesses, e.g., lower energy, albeit certain situations that diminish its effectiveness exist.
Subjugating Translational Inhibition in Response to Ribosomal Protein Insufficiency by a Herpesvirus Ribosome-Associated Protein (2020)

SUMMARY In addition to being required for protein synthesis, ribosomes and ribosomal proteins (RPs) also regulate mRNA translation in uninfected and virus-infected cells. By individually depleting 85 RPs using RNAi, we found overall protein synthesis in uninfected primary fibroblasts was more sensitive to RP-depletion than those infected with herpes simplex virus-1 (HSV-1). Although representative RP-depletion (uL3, uS4, uL5) inhibited protein synthesis in cells infected with other DNA viruses, HSV-1-infected cell protein synthesis unexpectedly endured and required a single virus-encoded gene product, VP22. During individual RP-insufficiency, VP22-expressing HSV-1 replicated better than a VP22-deficient variant. Furthermore, VP22 cosedimented with ribosomes and polyribosomes in infected cells. This identifies VP22 as a virus-encoded, polyribosome-associated protein that compensates for RP-insufficiency to support viral protein synthesis and replication. Moreover, it reveals an unanticipated class of virus-encoded, ribosome-associated effectors that reduce the dependence of protein synthesis upon RPs and broadly support translation during physiological stress such as infection.
'The most connected place on the planet' (2024)

This article explores episodes in Tasmania's communications history, the reasons it has been chosen to lead the deployment of the National Broadband Network and the crucial role of the Basslink cable, which began providing wholesale communications services to and from the island in July 2009. It then examines the most recent round of measures to improve communications in the State in the decade from 1996. These measures, funded from some of the proceeds of the privatisation of Telstra, favoured Tasmania because of the make-up of the Senate at the time. Despite this attention, continuing dissatisfaction with the state of telecommunications in Tasmania highlights the scale of the challenge for those now attempting again to conquer the remoteness that has been Tasmania's fate since European settlement.
Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation (2003)

Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating mothers and is associated with rapid bone loss. The mechanisms of bone loss during lactation are only partly understood. Several studies have suggested that parathyroid hormone-related protein (PTHrP) might be secreted into the circulation by the lactating mammary gland and regulate bone turnover during lactation. Because mammary development fails in the absence of PTHrP, conventional PTHrP knockout mice cannot be used to address this possibility. To examine this hypothesis, we therefore used mice carrying a beta-lactoglobulin promoter-driven Cre transgene, one null PTHrP allele, and one floxed PTHrP allele. Expression of Cre specifically in mammary epithelial cells during late pregnancy and lactation resulted in efficient deletion of the PTHrP gene; mammary gland PTHrP mRNA and milk PTHrP protein were almost completely absent. Removal of PTHrP from the lactating mammary glands resulted in reductions in levels of circulating PTHrP and 1,25-dihydroxy vitamin D and urinary cAMP. In addition, bone turnover was reduced and bone loss during lactation was attenuated. We conclude that during lactation mammary epithelial cells are a source of circulating PTHrP that promotes bone loss by increasing rates of bone resorption.