gebhart/patrepeval huggingface dataset:
The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and VoacangineM. F. Bartlett, D. F. Dickel, and W. I. TaylorCite this: J. Am. Chem. Soc. 1958, 80, 1, 126–136Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://doi.org/10.1021/ja01534a036RIGHTS & PERMISSIONSArticle Views1157Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Performance and limitations of chirped grating lenses of ti-indiffused liNbO3planar waveguides (1984)

Etched and deposited groove chirped grating lenses have been successfully designed, fabricated, and evaluated for the first time on Ti-indiffused LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> waveguides. The design procedure, the expected and measured performances, the materials and fabrication processes developed, and the performance limitations imposed by the waveguide parameters and by the fabrication procedures are presented.
Gradual Reduction of PV Generator Yield due to Pollution (1998)

Since spring 1994 the PV-laboratory of HTA Burgdorf has operated a new test center for PV-systems with a solar generator of 60 kWp on top of the new building of the department of electrical engineering. In course of time, a development of a permanent pollution strip was observed which caused a gradual reduction of energy yield of up to 10% until the end of 1997. The most important external source of unusual pollution at this location is a main railway line (Berne-Zurich) at a distance of only about 50m. Pollution by iron dust from railway lines seems to favor development of permanent pollution strips at the edges of framed modules. As soon as pioneer plants begin to grow, this effect is enhanced, as they retain all kinds of dust arriving on the modules. Under such conditions a periodical cleaning of a PV generator seems to be necessary. To cure this problem, artifical cleaning in June 1998 became necessary. Measurements of IV-curves before and after cleaning have proved that most of the power loss is reversible.
Controlled Photon Switch Assisted by Coupled Quantum Dots (2015)

Quantum switch is a primitive element in quantum network communication. In contrast to previous switch schemes on one degree of freedom (DOF) of quantum systems, we consider controlled switches of photon system with two DOFs. These controlled photon switches are constructed by exploring the optical selection rules derived from the quantum-dot spins in one-sided optical microcavities. Several double controlled-NOT gate on different joint systems are greatly simplified with an auxiliary DOF of the controlling photon. The photon switches show that two DOFs of photons can be independently transmitted in quantum networks. This result reduces the quantum resources for quantum network communication.
Homology Modeling of the Serotonin Transporter: Insights into the Primary Escitalopram‐binding Site (2007)

The serotonin transporter (SERT) is one of the neurotransmitter transporters that plays a critical role in the regulation of endogenous amine concentrations and therefore is an important target for therapeutic agents affecting the central nervous system. The recently published, high resolution X-ray structure of the closely related amino acid transporter, Aquifex aeolicus leucine transporter (LeuT), provides an opportunity to develop a three-dimensional model of the structure of SERT. We present herein a homology model of SERT using LeuT as the template and containing escitalopram as a bound ligand. Our model explains selectivities known from mutational studies and varying ligand data, which are discussed and illustrated in the paper.
A simple device for the preparation of end-surfaces of single optical fibres up to diameters of 0.7 mm (1984)

This is a description of a simple device for cutting optical fibres up to diameters of 0.7 mm, with the help of which end-surfaces of high optical quality can be achieved. The device can be mounted quickly and without effort on an optical bench.
Giant Cell Tumors of the Axial Skeleton (2012)

Background. We report on 19 cases of giant cell tumor of bone (GCT) affecting the spine or sacrum and evaluate the outcome of different treatment modalities. Methods. Nineteen patients with GCT of the spine (n = 6) or sacrum (n = 13) have been included in this study. The mean followup was 51.6 months. Ten sacral GCT were treated by intralesional procedures of which 4 also received embolization, and 3 with irradiation only. All spinal GCT were surgically treated. Results. Two (15.4%) patients with sacral and 4 (66.7%) with spinal tumors had a local recurrence, two of the letter developed pulmonary metastases. One local recurrence of the spine was successfully treated by serial arterial embolization, a procedure previously described only for sacral tumors. At last followup, 9 patients had no evidence of disease, 8 had stable disease, 1 had progressive disease, 1 died due to disease. Six patients had neurological deficits. Conclusions. GCT of the axial skeleton have a high local recurrence rate. Neurological deficits are common. En-bloc spondylectomy combined with embolization is the treatment of choice. In case of inoperability, serial arterial embolization seems to be an alternative not only for sacral but also for spinal tumors.
Abstract 1450: Anti-EGF antibodies generated by vaccination significantly improve the activity of kinase inhibitors in preclinical models (2019)

Abstract Background: We have previously described that EGF blocks the activity of EGFR tyrosine kinase inhibitors (EGFR-TKIs) in EGFR mutant NSCLC cells, an effect that is reversed by anti-EGF antibodies generated by vaccination (anti-EGF VacAbs) (1). In this study we aimed to determine the effect of EGF and anti-EGF Vac Abs in the activity of different kinase inhibitors in tumor cell lines with different genetic alterations. Methods: Anti-EGF VacAbs were obtained by immunizing rabbits with recombinant EGF. The cell lines used in this study were H2228 and H3122 (NSCLC, EML4-ALK positive), H23 (NSCLC, KRAS-G12C), DLD1 (colorectal carcinoma, KRAS-G13D), PC9 and PC9-GR4 (NSCLC, EGFR-mut). Tumor cell lines were treated with EGF, anti-EGF VacAbs and combinations with the kinase inhibitors alectinib, crizotinib, brigatinib (ALK inhibitors), trametinib (MEK inhibitor), dacomitinib and osimertinib (EGFR inhibitors). Cell viability was analyzed by MTT, changes of total and phosphorylated proteins were determined by Western blot and emergence of resistance by direct microscopic examination in low density cultures. Results: EGF significantly decreased the antitumor activity of alectinib, crizotinib and brigatinib in ALK translocated cells (H2228 and H3122), trametinib in KRAS mutant cells (H23 and DLD1) and osimertinib and dacomitinib in EGFR mutant cells (PC9). In combination with these TKIs, the anti-EGF VacAbs reversed the effects of EGF and significantly potentiated the antitumor activity of all the kinase inhibitors, blocking the activation of EGFR, Akt and Erk. Finally, the addition of the anti-EGF VacAbs to the culture medium delayed the appearance of resistant clones to kinase inhibitors. Conclusions: Anti-EGF VacAbs potentiate the antitumor effects of ALK, MEK and EGFR kinase inhibitors in tumor cell lines and delay the emergence of resistance in vitro. A clinical trial is currently testing anti-EGF vaccination in combination with afatinib in EGFR-mut advanced NSCLC patients.(1)Anti-Epidermal Growth Factor Vaccine Antibodies Enhance the Efficacy of Tyrosine Kinase Inhibitors and Delay the Emergence of Resistance in EGFR Mutant Lung Cancer Cells” Codony-Servat J, García-Roman S, Molina-Vila MÁ, et al. J Thorac Oncol. 2018. Citation Format: Jordi Codony-Servat, Silvia Garcia-Roman, Miguel Ángel Molina-Vila, Jordi Bertran-Alamillo, Ana Giménez-Capitán, Santiago Viteri, Andrés F. Cardona, Delvys Rodríguez, Manuel Cobo, Noemi Reguart, Niki Karachaliou, Erik d'Hondt, Rafael Rosell. Anti-EGF antibodies generated by vaccination significantly improve the activity of kinase inhibitors in preclinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1450.
A study of thin liquid sheet flows (1993)

This study was a theoretical and experimental investigation of thin liquid sheet flows in vacuum. A sheet flow created by a narrow slit of width, W, coalesces to a point at a distance, L, as a result of surface tension forces acting at the sheet edges. As the flow coalesces, the fluid accumulates in the sheet edges. The observed triangular shape of the sheet agrees with the calculated triangular result. Experimental results for L/W as a function of Weber number, We, agree with the calculated result, L/W = the sq. root of 8We. The edge cross sectional shape is found to oscillate from elliptic to 'cigar' like to 'peanut' like and then back to elliptic in the flow direction. A theoretical one-dimensional model was developed that yielded only elliptic solutions for the edge cross section. At the points where the elliptic shapes occur, there is agreement between theory and experiment.
Parallel EELS elemental mapping in scanning transmission electron microscopy: use of the difference methods (1991)

The feasibility to obtain semi-quantitative elemental maps with a STEM microscope from first or second difference recorded PEELS spectra is demonstrated. These methods called "FD or SD methods" have been already used for the local quantitative analysis of trace elements. It has been shown that it can be a powerful technique to overcome the problems related to the background subtraction and inhomogeneous responses of adjacent diodes in PEELS spectra and also to greatly improve the detectability of the elements. We extended this technique to create semi-quantitative multi-element maps on biological material. The experiments are done with a 300 kV STEM (C.M. 30 Philips) coupled with a GATAN PEELS and an EDAX computer. A software developed on a host computer allows the control of the STEM probe position and the acquisition of energy shifted EELS spectra for each pixel. By comparing elemental maps obtained, with the conventional method (power law background generation and subtraction above the edge), and with the difference methods we demonstrate both the validity and the advantages offered by FD and SD methods to create multi-elements semi-quantitative maps.
Polyethylene glycol and polyvinyl alcohol as corrosion inhibitors for aluminium in acidic medium (2007)

Abstract The corrosion inhibition of aluminum in H 2 SO 4 in the presence of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) as inhibitors at 30–60 °C was studied using gravimetric, gasometric, and thermometric techniques. The inhibition efficiency (%I) increased with increase in concentration of the inhibitors. Increase in temperature increased the corrosion rate in the absence and presence of inhibitors but decreased the inhibition efficiency. Both PEG and PVA were found to obey Temkin adsorption isotherm at all concentrations and temperatures studied. Phenomenon of physical adsorption is proposed from the activation parameters obtained. Thermodynamic parameters reveal that the adsorption process is spontaneous. PEG was found to be a better inhibitor than PVA. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
Local Burr distribution estimator for speckle statistics (2022)

Speckle statistics in ultrasound and optical coherence tomography have been studied using various distributions, including the Rayleigh, the K, and the more recently proposed Burr distribution. In this paper, we expand on the utility of the Burr distribution by first validating its theoretical framework with numerical simulations and then introducing a new local estimator to characterize sample tissues of liver, brain, and skin using optical coherence tomography. The spatially local estimates of the Burr distribution's power-law or exponent parameter enable a new type of parametric image. The simulation and experimental results confirm the potential for various applications of the Burr distribution in both basic science and clinical realms.
ChemInform Abstract: Evaluating the Potential of Vacuolar ATPase Inhibitors as Anticancer Agents and Multigram Synthesis of the Potent Salicylihalamide Analogue Saliphenylhalamide (V). (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kraftkonstanten tetraedrischer Oxoanionen des Mangans (MnO4-, MnO42-, MnO43-) und Rutheniums (RuO4, RuO4-, RuO42-) (1967)

Abstract Force constants of a modified valence force field (M.V.F.F.), a general valence force field (G.V.F.F.) and the Urey-Bradley force field (U.B.F.F.) are calculated for MnO4 -, MnO4 2-, MnO4 3-, RuO4, RuO4 -, and RuO4 2-. In the series of the manganates as well as the ruthenates the metal-oxygen stretching force constants show a nearly linear dependence on the formal oxydation number of the central metal atom. This is explained on the basis of molecular orbital theory. The L matrix method of Morino is used to calculate the mean square amplitudes of vibration for the same ions.
A Statistical Model of Shared Variability in the Songbird Auditory System (2017)

Abstract Vocal communication evokes robust responses in primary auditory cortex (A1) of songbirds, and single neurons from superficial and deep regions of A1 have been shown to respond selectively to songs over complex, synthetic sounds. However, little is known about how this song selectivity arises and manifests itself on the level of networks of neurons in songbird A1. Here, we examined the network-level coding of song and synthetic sounds in A1 by simultaneously recording the responses of multiple neurons in unanesthetized zebra finches. We developed a latent factor model of the joint simultaneous activity of these neural populations, and found that the shared variability in the activity has a surprisingly simple structure; it is dominated by an unobserved latent source with one degree-of-freedom. This simple model captures the structure of the correlated activity in these populations in both spontaneous and stimulus-driven conditions, and given both song and synthetic stimuli. The inferred latent variability is strongly suppressed under stimulation, consistent with similar observations in a range of mammalian cortical regions.
Molecular and Cellular Mechanisms of Water-Filtered IR (2022)

Abstract Water-filtered infrared A (wIRA) has been used to produce tissue hyperthermia to treat cancer, but also to treat a variety of other conditions, such as wound healing, pain, and inflammation. While the mechanism of anti-cancer hyperthermia is well-established, the mechanism of wIRA to promote healing and pain reduction is less clear. In this chapter, I will cover the use of photobiomodulation to treat several conditions characterized by mitochondrial dysfunction. Next the role of heat-sensitive transient receptor potential (TRP) ion channels is discussed, with regard to nitric oxide production and infrared neural stimulation. Then the use of infrared emitting bioceramic nanoparticles embedded in garments or patches, which are powered solely by body heat to promote healing and reduce pain and inflammation is discussed. The conclusion is that wIRA can activate heat-sensitive TRP channels, possibly mediated by energy absorption by nanostructured water clusters, leading to many of the observed therapeutic benefits.
Performance of an Automated Polysomnography Scoring System Versus Computer-Assisted Manual Scoring (2013)

The automatic system yielded results that were similar to those obtained by experienced technologists. Very good ICCs were obtained for many primary PSG outcome measures. This automated scoring software, particularly if supplemented with manual editing, may increase laboratory efficiency and standardize PSG scoring results within and across sleep centers.
Development and applications of new technology for two-dimensional space-time characterization and correlation analysis of ultraweak biophoton information. (1996)

We describe the spatial distribution and temporal correlation analysis of ultraweak biophoton emission based on photoelectron pulse time series and position measurement techniques. Experimental results on the spatio-temporal variation of biophoton emission from soybean seedlings after physical and chemical stimulation to the root tip are analyzed. Our results suggest the potential usefulness of this technique to quantify the transmission mechanisms of biological signals in the living system by measuring the biophoton emission.
Document image matching and annotation lifting (2002)

Two images of the same document could differ significantly due to faxing, scanner distortions, or degradation through multigeneration copying. Additionally, one of the images may have extensive annotations not present in the other. We give a method for registering two such images and separating out annotations. We further present an algorithm for detecting and repairing broken strokes in the annotations. Our methods have been tested on a wide variety of documents with reliable results; for the special case of form dropout our results are better than had been obtained previously with special-purpose algorithms.
Crystal structure and spin reorientation transition of Tb1−xYxFe11Mo compounds (2006)

The structural and magnetic properties of mixed compounds Tb1-xYxFe11Mo with x = 0-1.0 have been investigated by means of x-ray diffraction and magnetic measurements. The compounds crystallize in the tetragonal ThMn12-type structure with space group I4/mmm. The lattice parameters a, c and the unit-cell volume V vary slightly with the Y content, since the atomic radius of Y is close to that of Th. The Curie temperature of the compounds increases for x <= 0. 1, then decreases with the increase in the Y concentration. Spin reorientation phenomena in the Tb1-xYxFe11Mo compounds have been studied in detail. The room temperature easy-magnetization direction of Tb1-xYxFe11Mo compounds changes from planar to the c-axial with increasing Y concentration. Variation of the anisotropy constants of the Fe-sublattice K-1(Fe) (T) with temperature is determined experimentally. By minimizing the magnetocrystalline anisotropy energy, the derived spin reorientation temperature for the Tb1-xYxFe11Mo system shows reasonable agreement with the observations.
Distributed Cooperative Secondary Control of Microgrids Using Feedback Linearization (2013)

This paper proposes a secondary voltage control of microgrids based on the distributed cooperative control of multi-agent systems. The proposed secondary control is fully distributed; each distributed generator only requires its own information and the information of some neighbors. The distributed structure obviates the requirements for a central controller and complex communication network which, in turn, improves the system reliability. Input-output feedback linearization is used to convert the secondary voltage control to a linear second-order tracker synchronization problem. The control parameters can be tuned to obtain a desired response speed. The effectiveness of the proposed control methodology is verified by the simulation of a microgrid test system.
Vibration tests for bearing wear (2000)

This article discusses an example of an outer race-bearing defect on a 1,250 ton (4400 kW) air-conditioning chiller. The defect was detected using off-the-shelf portable vibration analysis hardware and software. The machine is a single-stage centrifugal compressor with a rolling element thrust bearing on the motor free end and a sleeve bearing on the motor drive end. This article discusses methods used to diagnose and trend the bearing defect using vibration spectra as an indicator of the bearing condition. The diagnostic methods covered are universally applicable to other types of machines (pumps, fans, gears) with rolling contact bearings.
Design of styryl dye single crystals in the presence of low-molecular aromatic compounds and peculiarities of [2+2]-photocycloaddition in these single crystals (2008)

A variety of crystal packing motifs for styryl dye Et-Py+-CH=CH-C6H4OMe ClO 4 − crystallized from solvent mixtures containing different low-molecular aromatic compounds was investigated by X-ray diffraction method. The presence of some of these aromatic compounds was found to affect the mode of the aggregation of the dye structural units in the course of crystal nucleation, regardless of whether these compounds are involved in the growing crystal. The aromatic molecules containing two proton-donating groups can be involved in the crystal packing of the dye as a solvate that forms weak hydrogen bonds with perchlorate anions or other solvate molecules. The aromatic molecules without functional groups (except for benzene) are not involved in the growing crystal as additional building blocks. The syn-head-to-tail stacking with contiguous and antiparallel arrangement of the ethylene bonds is the main packing motif of dye cations in crystals of unsolvated and solvated forms. This is favorable for accomplishing the [2+2]-photocycloaddition (PCA) reaction resulting in the centrosymmetric rctt-isomer of a cyclobutane derivative. In the solvated forms of the crystals, the solvate molecules and perchlorate anions form loose layers between the cation stacks. These layers are capable of leveling internal stresses caused by the PCA reaction, thus promoting this reaction as a single-crystal-to-single-crystal transformation. Other conditions for the PCA reaction to proceed without single crystal degradation are (1) retention of the initial crystal symmetry in the course of the PCA and (2) stack separation into dimeric pairs with d 1 < 4.2 Å < d 2, where d 1 and d 2 are the distances between the ethylene bonds within the dimeric pairs and between them, respectively. The regularities found for the crystal packing and the PCA reaction in styryl dye single crystals may be used to design information recording and storage cells.