gebhart/patrepeval huggingface dataset:
Strategies for combating bacterial biofilm infections (2014)

Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents.
Cell-permeable Tat-NBD peptide attenuates rat pancreatitis and acinus cell inflammation response (2009)

Our result supports that active NF-kappaB participates in the pathogenesis of STC-induced acute pancreatitis in rats. Tat-NBD (WT) peptide has anti-inflammatory effects in this model and inhibits the inflammation of acinus simulated by LPS.
Locating a Silane Coupling Agent in Silica-Filled Rubber Composites by EFTEM (2007)

A silane coupling agent (SA) was added to silica/rubber composites at different mixing temperatures and the formation of a coupling layer at the silica/rubber interface was investigated by energy-filtering transmission electron microscopy. Bis(triethoxysilypropyl)tetrasulfane (TESPT), which was used as the SA, reacted with the silanol groups on the silica surface and with styrene-butadiene rubber to form an interfacial coupling layer. The silicon and sulfur elemental distributions were analyzed by electron energy loss spectroscopy (EELS) and elemental mapping. The amount of TESPT trapped in the rubber matrix could be qualitatively estimated by EELS, and the in situ formed coupling layer could be characterized by elemental mapping. The result indicated that the formation of the coupling layer was affected by the mixing temperature. The technique described here will contribute to the study of interface-property relationships and the evaluation of the role of SAs in polymeric composites.
A comprehensive guide to MEGA-PRESS for GABA measurement (2023)

The aim of this guideline is to provide a series of evidence-based recommendations that allow those new to using MEGA-PRESS to produce high-quality data for the measurement of GABA levels using edited magnetic resonance spectroscopy with the MEGA-PRESS sequence at 3T. GABA is the main inhibitory neurotransmitter of the central nervous system and has been increasingly studied due to its relevance in many clinical disorders of the central nervous system. MEGA-PRESS is the most widely used method for quantification of GABA at 3T, but is technically challenging and operates at a low signal-to-noise ratio. Therefore, the acquisition of high-quality MRS data relies on avoiding numerous pitfalls and observing important caveats. The guideline was developed by a working party that consisted of experts in MRS and experts in guideline development and implementation, together with key stakeholders. Strictly following a translational framework, we first identified evidence using a systematically conducted scoping literature review, then synthesized and graded the quality of evidence that formed recommendations. These recommendations were then sent to a panel of 21 world leaders in MRS for feedback and approval using a modified-Delphi process across two rounds. The final guideline consists of 23 recommendations across six domains essential for GABA MRS acquisition (Parameters, Practicalities, Data acquisition, Confounders, Quality/reporting, Post-processing). Overall, 78% of recommendations were formed from high-quality evidence, and 91% received agreement from over 80% of the expert panel. These 23 expert-reviewed recommendations and accompanying extended documentation form a readily useable guideline to allow those new to using MEGA-PRESS to design appropriate MEGA-PRESS study protocols and generate high-quality data.
Oncolytic Efficacy of Recombinant Vesicular Stomatitis Virus and Myxoma Virus in Experimental Models of Rhabdoid Tumors (2008)

These results suggest that VSV(DeltaM51) and MV could be novel effective therapies against human rhabdoid tumor.
Enhancing the performance of photovoltaic panels by water cooling (2013)

The objective of the research is to minimize the amount of water and electrical energy needed for cooling of the solar panels, especially in hot arid regions, e.g., desert areas in Egypt. A cooling system has been developed based on water spraying of PV panels. A mathematical model has been used to determine when to start cooling of the PV panels as the temperature of the panels reaches the maximum allowable temperature (MAT). A cooling model has been developed to determine how long it takes to cool down the PV panels to its normal operating temperature, i.e., 35 °C, based on the proposed cooling system. Both models, the heating rate model and the cooling rate model, are validated experimentally. Based on the heating and cooling rate models, it is found that the PV panels yield the highest output energy if cooling of the panels starts when the temperature of the PV panels reaches a maximum allowable temperature (MAT) of 45 °C. The MAT is a compromise temperature between the output energy from the PV panels and the energy needed for cooling.
Change in Surface Properties of Fabrics During Wear (1989)

We describe a new method of monitoring the surface properties of textile fabrics during abrasion and give results of tests performed on 20 different samples. Further, we correlate the abrasion resistance with the surface properties, areal density, and thickness of the fabrics.
Orientation-patterned templates GaAs/Ge/GaAs for nonlinear optical devices. I. Molecular beam epitaxy (2017)

GaAs/Ge/GaAs heterostructures in which the GaAs layer lattice on Ge is rotated at a right angle to the substrate plane are grown by molecular-beam epitaxy (MBE). Such heterostructures are grown in different epitaxial setups for GaAs and for Ge with wafer transfer through air tor the first time. It is proposed to use surfactants (Bi, Sb) to control GaAs layer nucleation on Ge.
The Meat Freshness Monitoring System Using the Smart RFID Tag (2014)

This paper proposes a monitoring system for meat freshness and use-by date, based on the smart RFID (radio frequency identification) tag. Freshness can be checked by various factors, such as the presence of microorganisms, bacteria, and gases. This paper focuses on detecting the temperature, humidity, and the gases released by meat. We analyzed the factors affecting the freshness of meat and decided to use a gas sensor as the main detection method. We use temperature sensor and humidity sensor as auxiliary sensors to get the food poisoning index. The proposed system consists of an RFID tag, temperature sensor, humidity sensor, gas sensor, reader, and server. By comparing the temperature, humidity, and gas concentration of the meat storage environment, we can get the relationship between meat freshness and the sensor signal. This monitoring system can show the meat freshness at four distinct grades: High, Medium, Low, and Spoilage. In order to confirm the usefulness of the proposed system, we performed experiments on pork. With the smart RFID tag, we successfully estimated the freshness of the meat.
Invasive lobular carcinoma of the breast: incidence and variants (1979)

The criteria for the separation of invasive lobular and ductal carcinomas are analysed. Lobular tumours account for 14% of invasive cancers in our material. The widely differing figures given in the literature are mainly attributable to intrinsic difficulties of classification. In addition to the classical dissociated-cell patterns with single filing, a tragetoid appearance and related features, variants with trabecular, loose alveolar and tubular features are recognized; a 'solid' variant requires further investigation. The variants either represent better differentiated forms, or in some cases, an 'earlier' phase in the production of the more traditional Indian file formations and dartboard patterns. Focal signet-ring cell differentiation is another newly-recognized feature. The theoretical and practical implications of these variants are considered. The division into invasive lobular and ductal carcinomas is not as easy as most of the literature implies. Five per cent of cases could not be so classified and, in some of these unclassified cases, both ductal and lobular differentiation may be present. In the diagnosis of problem cases, no single parameter proved reliable but a combination of several parameters enables one to make an objective diagnosis in about 95% of cases.
Anti-Edema Action of Formoterol in Rat Trachea Does Not Depend on Capsaicin-Sensitive Sensory Nerves (1994)

The beta 2-adrenergic agonist formoterol has been shown to inhibit plasma extravasation in the respiratory mucosa associated with neurogenic inflammation as well as that caused by histamine or bradykinin. It is unknown whether these effects of formoterol are mediated through an action of sensory nerves or through a direct effect on the leaky blood vessels. In the present study we sought to determine whether capsaicin-sensitive sensory nerves are essential for the anti-edema effect of formoterol in the rat trachea. Substance P (5 micrograms/kg), PAF (hexadecyl-PAF, 5 micrograms/kg), or bradykinin (10 mg/kg) was injected intravenously to increase vascular permeability. The amount of plasma extravasation was measured with two tracers, Evans blue dye and Monastral blue pigment. The effectiveness of formoterol's anti-edema action was assessed in two groups of rats. One was pretreated with capsaicin to eliminate tachykinin-containing sensory nerves and another, the control group, was not pretreated. We found that in control rats formoterol inhibited to a similar extent the extravasation of Evans blue and Monastral blue caused by all three mediators. The highest intravenous dose of formoterol (10 micrograms/kg) reduced substance P-induced extravasation of Monastral blue by 59%, reduced PAF-induced extravasation by 74%, and reduced bradykinin-induced extravasation by 58%. Pretreatment of rats with a dose of capsaicin that eliminated at least 94% of the substance P-immunoreactive nerve fibers did not significantly reduce the effectiveness of formoterol against any of the mediators.(ABSTRACT TRUNCATED AT 250 WORDS)
Application of Convolutional Neural Networks to Language Identification in Noisy Conditions (2014)

This paper proposes two novel frontends for robust language identification (LID) using a convolutional neural network (CNN) trained for automatic speech recognition (ASR). In the CNN/i-vector frontend, the CNN is used to obtain the posterior probabilities for i-vector training and extraction instead of a universal background model (UBM). The CNN/posterior frontend is somewhat similar to a phonetic system in that the occupation counts of (tied) triphone states (senones) given by the CNN are used for classification. They are compressed to a low dimensional vector using probabilistic principal component analysis (PPCA). Evaluated on heavily degraded speech data, the proposed front ends provide significant improvements of up to 50% on average equal error rate compared to a UBM/i-vector baseline. Moreover, the proposed frontends are complementary and give significant gains of up to 20% relative to the best single system when combined.
Recombinant P-selectin glycoprotein ligand–1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect (2003)

Selectin-dependent leukocyte rolling is one of the earliest steps of an acute inflammatory response and, as such, contributes to many inflammatory diseases. Although inhibiting leukocyte rolling with selectin antagonists is a strategy that promises far-reaching clinical benefit, the perceived value of this strategy has been limited by studies using inactive, weak, or poorly characterized antagonists. Recombinant P-selectin glycoprotein ligand-1-immunoglobulin (rPSGL-Ig) is a recombinant form of the best-characterized selectin ligand (PSGL-1) fused to IgG, and is one of the best prospects in the search for effective selectin antagonists. We have used intravital microscopy to investigate the ability of rPSGL-Ig to influence leukocyte rolling in living blood vessels and find that it can reduce rolling dependent on each of the selectins in vivo. Interestingly, doses of rPSGL-Ig required to reverse pre-existing leukocyte rolling are 30-fold higher than those required to limit inflammation, suggesting additional properties of this molecule. In support of this, we find that rPSGL-Ig can bind the murine chemokine KC and inhibit neutrophil migration toward this chemoattractant in vitro.
Fiber Distributed Brillouin Sensing with Optical Correlation Domain Techniques (2014)

By applying correlation domain techniques to Brillouin scattering in optical fibers, distributed sensing for strain and/or temperature has been realized with mm-order resolution, kHz-order sampling-rate, and random accessibility. Strain/temperature discriminative measurement has also been demonstrated.
Analysis of ultra capacitors as UPS energy storage devices (2010)

This paper is a guide to solving some introductory problems encountered when considering ultra capacitors as an energy storage solution for power electronics. The methods used here can be used by the engineer to find solutions for many other applications that can not be found with conventional calculus.
Multi-modality in one-class classification (2010)

We propose a method for improving classification performance in a one-class setting by combining classifiers of different modalities. We apply the method to the problem of distinguishing responsive documents in a corpus of e-mails, like Enron Corpus. We extract the social network of actors which is implicit in a large body of electronic communication and turn it into valuable features for classifying the exchanged documents. Working in a one-class setting we folow a semi-supervised approach based on the Mapping Convergence framework. We propose an alternative interpretation, that allows for broader applicability when positive and negative items are not naturally separable. We propose an extension to the one-class evaluation framework in truly one-case cases when only some positive training examples are available. We extent the one-class setting to the co-training principle that enables us to take advantage of multiple views on the data. We report evaluation results of this extension on three different corpora including Enron Corpus.
Cytokine profile during the clinical course of toxic shock syndrome (2009)

Toxic shock syndrome (TSS) is an acute febrile disease with multiple organ involvement caused by massive and rapid release of cytokines induced by staphylococcal exotoxins. However, the precise cytokine profile is still undefined in clinical cases. We measured serum cytokine concentrations in a patient who developed TSS after a caesarean section. Measurements were taken on admission and several times during the course of the disease. Methicillin-resistant Staphylococcus aureus producing TSS toxin-1 and staphylococcal enterotoxin C was detected in the lochia and venous blood. Serum interleukin (IL)-6 level was markedly increased on admission, and IL-10, tumour necrosis factor-alpha, and interferon-gamma levels were also raised. These cytokine levels rapidly returned to normal levels. In contrast, IL-1beta and IL-2 were below the analytical sensitivity threshold throughout the course. Our data and other previous case reports indicate that a marked increase in IL-6 concentration could be a clinical marker of TSS onset.
Improved utilisation of renewable resources: New important derivatives of glycerol (2007)

Although glycerol has been a well-known renewable chemical for centuries, its commercial relevance has increased considerably in the last few years because of its rising inevitable formation as a by-product of biodiesel production. The present review gives a broad overview on the chemistry of glycerol starting from the classic esters and oligomers to new products like glycerol carbonate, telomers, branched alkyl ethers, propanediols and epoxides. In particular, the novel possibilities to control the numerous addition, reduction and oxidation reactions via heterogeneous, homogeneous and biocatalysis will be presented. A benchmark will be given to determine the products which will have the best chances of entering the market and which processes are currently most developed.
Performance Characterisation and Simulation of Intel's Integrated GPU Architecture (2018)

Integrated GPUs (iGPUs) are ubiquitous in today's client devices such as laptops and desktops. Examples include Intel's HD or Iris Graphics and AMD's APUs. An iGPU resides on the same chip as the CPU, which is in contrast to a conventional discrete GPU that would typically be connected over the PCI-E bus. Much like discrete GPUs, iGPUs are also capable of general purpose computation in addition to traditional graphics roles. Further, iGPUs have some interesting differences compared to traditional GPUs such as a cache-coherent memory hierarchy and a shared last level cache with the CPU. Despite their wide spread use, they are not studied very extensively. To the best of our knowledge, this paper introduces the first open source trace generation and microarchitectural simulation framework for Intel's integrated GPUs. We characterise the performance of Intel's Skylake and Kabylake GPUs through detailed microbenchmarks, and use the performance evaluations to guide our models and validate the simulator.
Pickering Emulsions Stabilized by Monodisperse Latex Particles:  Effects of Particle Size (2001)

The preparation, type, and stability of emulsions of oil and water stabilized solely by spherical, monodisperse polystyrene latex particles of different size is described. Two types of behavior occur depending on whether particles remain intact (in the case of cyclohexane) or dissolve to give free polymer chains (in the case of toluene). Emulsions formed with cyclohexane and either “hydrophilic” aldehyde/sulfate particles or “hydrophobic” sulfate particles are water-in-oil (w/o) over a wide range of salt concentrations and water volume fractions. Average emulsion drop diameters initially increase from 35 to 75 μm with increasing particle diameter and then remain constant. Although such emulsions sediment, there is no sign of coalescence for over 6 months. We show evidence of the transition from nonflocculated to flocculated emulsions upon increasing the water volume fraction, as predicted theoretically for charged drops in oil. By use of toluene and “hydrophilic” particles however, emulsions can be inverted from oil-in-water (o/w) to w/o with increasing salt concentration. The concentration of salt required to screen the repulsions between negatively charged adsorbed polymers increases with initial particle size as the average molecular weight also increases. Water-in-oil emulsions, of around 1 μm diameter, are stable to coalescence for long periods.
Charte canadienne et droits linguistiques (2017)

Quels sont les impacts réels de la Charte canadienne en matière de droits linguistiques ? Son adoption a-t-elle réellement participé au recul du fait français au Québec et amoindri la portée de la loi 101 ? C’est ce que croient de très nombreux Québécois et, depuis les années 1970, cette croyance s’est érigée en doxa chez les natio­nalistes indépendantistes ; chez les nationalistes fédéralistes du Québec, elle fait figure de tabou… Mais qu’en est-il vraiment ? En analysant minutieusement lois, règlements, décisions de la Cour suprême et autres déclarations de politiciens, Frédéric Bérard déconstruit patiemment le mythe créé et entretenu par la doctrine québécoise du nationalisme « méthodologique » en matière de droits linguistiques. Il révèle non seulement que les seuls « gagnants » des débats juridiques relatifs à ces droits, depuis 1982, sont les francophones hors Québec, mais il met aussi en lumière les limites du droit à protéger ou à promouvoir une culture, quelle qu’elle soit. Sans sombrer dans l’angélisme, l’auteur met cet épineux débat en contexte : il livre un historique pré-charte et s’attarde sur le traitement controversé qu’ont fait subir les différents gouvernements du Québec aux minorités fran­cophones du pays.
Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. (1991)

The protooncogene ras acts as a component of signal-transduction networks in many kinds of cells. The ras gene product (p21) is a GTP-binding protein, and the activity of the protein is regulated by bound GDP/GTP. Recent studies have shown that a certain class of growth factors stimulates the formation of active p21-GTP complexes in fibroblasts and that oncogene products with enhanced tyrosine kinase activities have a similar effect on ras p21. We have measured the ratio of active GTP-bound p21 to total p21 in several lymphoid and myeloid cell lines in order to understand the role of ras in the proliferation of these cells. Interleukin 2 (IL-2), IL-3, and granulocyte/macrophage colony-stimulating factor (GM-CSF) enhance the formation of the active p21.GTP, whereas IL-4 has no effect on p21-bound GDP/GTP. These results strongly suggest that ras p21 acts as a transducer of signals from IL-2, IL-3, and GM-CSF, but not from IL-4.
12CO(J = 1 0) On-the-fly Mapping Survey of the Virgo Cluster Spirals. II. Molecular Gas Properties in Different Density Environments (2017)

Abstract This study investigated the properties of the molecular gas content and star formation activity of 17 Virgo spirals, 21 Ursa Major (UMa) spirals, 13 Pisces spiral galaxies, and a comparison sample of 11 field spiral galaxies with a spatially resolved gas and stellar distribution. The H i -deficient galaxies with a def H i &gt; 0.4 have a similar range of CO luminosity normalized by the K -band luminosity ( L CO / L K ) like the field spirals, although their CO content can be smaller by up to a factor of 2. The CO, H i , and stellar disk diameters are closely related to each other for both cluster and field galaxies, and the relative diameters of the CO and H i disks grow monotonically and smoothly as the H i -to-stellar disk diameter ratio decreases. Cluster galaxies have a molecular gas consumption time up to 10 times shorter than that of the field comparison sample, suggesting a significant change in the molecular gas content and star formation activity among all the cluster galaxies, even when they do not show any sign of H i stripping. The strongly H i -stripped Virgo cluster galaxies show only a modestly reduced total gas consumption time, indicating that the star formation activity and gas consumption are a highly local (rather than global) phenomenon. Our finding is that the depletion of cold gas by ram-pressure stripping and/or starvation caused by preprocessing in each cluster environment makes galaxies evolve passively.