gebhart/patrepeval huggingface dataset:
Demonstration-Efficient Guided Policy Search via Imitation of Robust Tube MPC (2021)

We propose a demonstration-efficient strategy to compress a computationally expensive Model Predictive Controller (MPC) into a more computationally efficient representation based on a deep neural network and Imitation Learning (IL). By generating a Robust Tube variant (RTMPC) of the MPC and leveraging properties from the tube, we introduce a data augmentation method that enables high demonstration-efficiency, being capable to compensate the distribution shifts typically encountered in IL. Our approach opens the possibility of zero-shot transfer from a single demonstration collected in a nominal domain, such as a simulation or a robot in a lab/controlled environment, to a domain with bounded model errors/perturbations. Numerical and experimental evaluations performed on a trajectory tracking MPC for a quadrotor show that our method outperforms strategies commonly employed in IL, such as DAgger and Domain Randomization, in terms of demonstration-efficiency and robustness to perturbations unseen during training.
Coherent phase control of the photodissociation of HOD (1993)

A goal of chemical reaction dynamics is to control the course of reactions. We are examining the photodissocation of HOD, which is attractive for coherent control studies. A fixed frequency laser at 600 nm and its third harmonic at 200 nm is used to simultaneously and coherently photodissociate the rovibrationally excited parent molecules. Preliminary experiments focussed on confirming individual steps of the complex experiment; results are given of three-photon dissociation of H{sub 2}O, which gives confidence for the HOD three-photon dissociation.
Prophylactic Dose of Dalteparin in Pregnant Women With History of Venous Thromboembolisms and/or Thrombophilia: Real-World Data (2022)

Women with a history of venous thromboembolisms (VTEs) and/or thrombophilia are at increased risk of VTE during pregnancy. We analysed our cohort of such women who were treated with a prophylactic doses of dalteparin. 152 pregnant women with 179 pregnancies were classified into 3 groups: (1) previous VTE without thrombophilia (122 pregnancies); (2) previous VTE with thrombophilia (26 pregnancies) and (3) thrombophilia only (31 pregnancies). They were treated with prophylactic dalteparin in the prepartum and postpartum periods or only in the postpartum period. Occurrences of symptomatic VTE and bleeding episodes were followed, as well as dalteparin discontinuation and anti-Xa activity. Symptomatic deep vein thrombosis occurred in 4 women (2.2%) with 2 episodes in group 1 (in the postpartum period) and 2 episodes in group 2 (one in the prepartum and another in the postpartum period). Seven episodes (3.9%) of minor bleeding occurred. Dalteparin was not stopped in any women. Anti-Xa levels were within the prophylactic range. Our real-world data show a low incidence of thrombosis and minor bleeding in pregnant women treated with prophylactic dalteparin. The incidence of recurrent VTE was lower than that reported in women with similar risk, but without prophylactic anticoagulation.
A three-dimensional (3D) printed paediatric trachea for airway management training (2020)

There is a deficit of commercially available paediatric airway models for anaesthesia airway management training, particularly for infant front-of-neck access and customised airway planning. Acknowledging this, we created a three-dimensional printed prototype for an affordable, high-fidelity training device, incorporating realistic tactile feedback, reproducibility and potential for modification for specific patient pathologies. Our model, created on a Stratasys Polyjet J750™ (Rehovot, Israel) printer, is a novel and useful educational tool in paediatric airway management, and we are pleased to share access to this resource with readers. Our work adds credence to three-dimensional printing as an accessible, reproducible and pluripotent technology in clinical anaesthesia.
Alternative edge illumination set-up for single-shot X-ray phase contrast imaging (2018)

Edge illumination (EI) is a promising X-ray phase contrast imaging (XPCI) technique and is expected to translate XPCI into practical applications with laboratory X-ray sources. However, traditional double-mask EI setup requires two acquisitions for extracting phase and absorption information. Although the latest single-mask EI setup allows phase retrieval with single-shot, it requires a nearly ideal detector point spread function (PSF). In this paper, an alternative EI setup is proposed, which remains double-mask but requires only a single-shot. It can implement single-shot XPCI and relax the detector requirements. Numerical calculations are carried out to compare the characteristics of the double- and single-mask EI setup and the proposed setup. The performance of this setup with different illumination conditions is evaluated theoretically. The results suggest that the proposed setup is less affected by the detector PSF compared to the single-mask EI setup and therefore has higher contrast and contrast-to-noise ratio. Phase retrieval can be implemented by this setup with a single-shot, which helps to simplify the operations and eliminate the potential errors in the double-mask EI setup. A narrow illumination width contributes to the contrast but adversely affects the radiation utilization efficiency, and some appropriate trade-offs should be selected according to the practical applications and experimental conditions. On the basis of this setup, the extraction of the quantitative phase and absorption information was also conducted by numerical calculation.
Data from Murine Microenvironment Metaprofiles Associate with Human Cancer Etiology and Intrinsic Subtypes (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Ionizing radiation is a well-established carcinogen in rodent models and a risk factor associated with human cancer. We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated &lt;i&gt;Trp53&lt;/i&gt;-null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naïve hosts. We asked whether expression metaprofiles could discern radiation-preceded human cancer or be informative in sporadic breast cancers.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Affymetrix microarray gene expression data from 56 Trp53-null mammary tumors were used to define gene profiles and a centroid that discriminates tumors arising in irradiated hosts. These were applied to publicly available human cancer datasets.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Host irradiation induces a metaprofile consisting of gene modules representing stem cells, cell motility, macrophages, and autophagy. Human orthologs of the host irradiation metaprofile discriminated between radiation-preceded and sporadic human thyroid cancers. An irradiated host centroid was strongly associated with estrogen receptor–negative breast cancer. When applied to sporadic human breast cancers, the irradiated host metaprofile strongly associated with basal-like and claudin-low breast cancer intrinsic subtypes. Comparing host irradiation in the context of TGF-β levels showed that inflammation was robustly associated with claudin-low tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Detection of radiation-preceded human cancer by the irradiated host metaprofile raises possibilities of assessing human cancer etiology. Moreover, the association of the irradiated host metaprofiles with estrogen receptor–negative status and claudin-low subtype suggests that host processes similar to those induced by radiation underlie sporadic cancers. &lt;i&gt;Clin Cancer Res; 19(6); 1353–62. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection (2018)

Studies of the role of <i>Schistosoma</i> co-infections on plasma HIV-1 RNA (HIV-1 viral load) have yielded incongruent results. The role of duration of HIV-1 infection on the link between <i>Schistosoma</i> and HIV-1 viral load has not been previously investigated. We aimed to assess the impact of HIV-1/<i>Schistosoma</i> co-infections on viral load in Antiretroviral Treatment (ART)-naïve HIV-1 infected people taking into account the duration of HIV-1 infection. We describe 79 HIV-infected outpatients greater than 18 years of age who had never used ART in Mwanza, Tanzania. Schistosomiasis testing was done by urine and stool microscopy and by serum <i>Schistosoma</i> circulating anodic antigen (CAA) testing. <i>Schistosoma</i> positivity was defined as having either test positive. We conducted univariable and multivariable linear regressions to assess the relationship between <i>Schistosoma</i> infection and the log<sub>10</sub> of viral load. Duration of HIV infection was calculated using the first measured CD4<sup>+</sup> T-cell (CD4) count as a function of normal CD4 count decay per calendar year in drug naïve individuals. An active <i>Schistosoma</i> infection was demonstrated in 46.8% of the patients. The median log<sub>10</sub> viral load was 4.5[3.4-4.9] log<sub>10</sub> copies/mL in <i>Schistosoma</i> uninfected patients and 4.3[3.7-4.6] log<sub>10</sub> copies/mL in <i>Schistosoma</i> infected patients. <i>Schistosoma</i> co-infection was negatively associated with the log<sub>10</sub> of viral load after adjustment for <i>Schistosoma</i> intensity as measured by CAA, CD4 counts at time of testing, and duration of HIV-1 infection (β = -0.7[-1.3;-0.1], <i>p</i> = 0.022). <i>Schistosoma</i> co-infection was not associated with viral load in univariable analysis. There was also no interaction between <i>Schistosoma</i> positivity and duration of HIV-1 infection. Our study is the first, to our knowledge, to report adjustment for duration of HIV-1 infection when analyzing the relationship between HIV-1 viral load and <i>Schistosoma</i> spp. We found that time infected with HIV-1 has a major effect on the relationship between HIV-1 viral load and <i>Schistosoma</i> infection and may be a critical explanatory factor in the disparate findings of studies on HIV-1 viral load and schistosomiasis. The log<sub>10</sub> viral load difference found indicates that <i>Schistosoma</i> co-infection does not make HIV progression worse, and could possibly lead to slower HIV disease progression.
Effects of grip force on skin conductance measured from a handheld device (2014)

Skin conductance (SC) reflects stimulus significance and can be measured by integrating electrodes directly onto a smartphone housing such that they are naturally contacted when gripped. However, grip artifacts naturally arise during operation since grip forces can vary. We explored the effects of grip force on SC to determine feasibility and to draw guidelines on artifact mitigation. For this purpose, a prototype was built with integrated SC electrodes with colocated force sensors, and data was collected from 24 participants gripping the prototype across different grip force conditions. Our analysis showed that static forces greater than 2.0 N were associated with significant SC distortion, and artifacts induced from dynamic grip forces were buffered if the SC level was at least 1.1 microsiemens. Our findings are relevant for future applications of SC sensing on smartphones, which may enable interesting and highly contextual user experiences.
Reversible Trapping of Functional Molecules at Interfaces Using Diazonium Salts Chemistry (2016)

Developing thin polymeric films for trapping, releasing, delivering, and sensing molecules is important for many applications in chemistry, biotechnology, and environment. Hence, a facile and scalable technique for loading specific molecules on surfaces would rapidly translate into applications. This work presents a novel method for the trapping of functional molecules at interfaces by exploiting diazonium salt chemistry. We demonstrate the efficiency of this approach by trapping two different molecules, 4-nitrobenzophenone and paracetamol, within polycarboxyphenyl layers grafted on gold and glassy carbon (GC) and by releasing them in acidic medium. The former molecule was chosen as a proof of concept for its electrochemical and spectroscopic properties, and the latter one was selected as an example of a pharmaceutical molecule. Advantages of the present approach rely on the simplicity, rapidity, and efficiency of the procedure for the reversible, on demand, trapping and release of functional molecules.
Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. (2002)

The ability to manipulate mouse pre-implantation embryos in vitro has become a valuable tool in many scientific disciplines. However, fewer embryos maintain viability following in vitro manipulation compared with embryos in vivo. It has been suggested that use of dynamic medium environments may improve viability by simulating in utero environment. The objective of the study reported here was to compare a microdrop in vitro culture system with a microdevice in vitro culture system containing a static and two dynamic medium environments (0.1 and 0.5 microl/h) for culturing of mouse pre-implantation embryos. Results indicated that the static medium environment, in silicon-glass microdevices, was not significantly different from the microdrop control environment in proportion of embryos developing from the two-cell to the blastocyst stage. However, the static microdevice environment produced significantly (P < 0.05) more morulas than did that of the control group. Both of these treatment groups, under the presented conditions, consistently had significantly higher proportions of blastocysts (P < 0.05) and morulas (P < 0.05) and lower proportions of abnormal (P < 0.05) and eight-cell embryos (P < 0.05), compared with those of the high flow rate dynamic environment microdevice treatment groups. Studies exploring slower or pulsatile rates of medium delivery in a dynamic medium environment are indicated.
Shared Governance, Health and Housing Working Hand in Glove: The South Australian Experience (2011)

The Street to Home initiative (STH) is an effort of joint collaboration between the federal government as well as several health, housing and support services in Australia. Some of the challenges involved in a dual governance structure where each requires its own decision making and accountability structures as well as key performance indicators and reporting requirement s are highlighted.
Effect of Statins on Venous Thromboembolic Events: A Meta-analysis of Published and Unpublished Evidence from Randomised Controlled Trials (2012)

The findings from this meta-analysis do not support the previous suggestion of a large protective effect of statins (or higher dose statins) on venous thromboembolic events. However, a more moderate reduction in risk up to about one-fifth cannot be ruled out.
Homology of human pancreatic stone protein with animal lectins (1988)

Correspondence| July 01 1988 Homology of human pancreatic stone protein with animal lectins L Patthy L Patthy Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1988 London: The Biochemical Society1988 Biochem J (1988) 253 (1): 309–311. https://doi.org/10.1042/bj2530309b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation L Patthy; Homology of human pancreatic stone protein with animal lectins. Biochem J 1 July 1988; 253 (1): 309–311. doi: https://doi.org/10.1042/bj2530309b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1988 London: The Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
A normative study of suggestibility in a mental patient population (1964)

Abstract The postural sway technique was used to make suggestibility measurements on a total of 490 Ss of which 279 were hospitalized psychiatric patients. The remaining Ss were “normal” college students. The “normal” Ss were significantly more suggestible than the psychiatric group. Within the psychiatric group, the psychotics, nonpsychotics, and organics differed significantly, with the nonpsychotics being least suggestible, the psychotics most suggestible, and the organics intermediate. The hospital group was further reduced into diagnostic subcategories and postural sway parameters were shown. The sample distributions were essentially normal although the sample drawn from a psychiatric population showed positive skewness.
A FORMAL GEOMETRICAL MODELLING OF WAVE ACTIONS FOR STRUCTURAL RELIABILITY (1995)

The actual challenge for the requalification of existing offshore structures through a rational process of reassessment leads to state the importance of Response Surface Methodology. At different steps along the quantitative analysis, quite a lot of approximations are performed as a surrogate for the original model in subsequent uncertainty and sensitivity studies. The authors propose a geometrical description of the n{sup th} order Stokes model in the form of a random linear combination of deterministic vectors. These vectors are obtained by rotation transformations of the wave directional vector. This allows to discuss the complexity level to be introduced in stochastic modeling of the wave actions, within its relevance for the probabilistic mechanics analysis of offshore structures. In situ measurements are used to perform ranges and distributions of basic variables. A striking feature is that the environmental actions are site specific.
Atypical glandular cells of undetermined significance and adenocarcinoma in situ: summoning colposcopic expertise? (1996)

In comparison with cervical squamous neoplasia, glandular cell neoplasia is uncommon. The evaluation of a patient with atypical glandular cells of undetermined significance is challenging because subtle colposcopic signs are frequently inaccessible to view and cytologic interpretations are extremely challenging for many cytopathologists.
Breakdown in millimeter-wave power InP HEMTs: a comparison with PHEMTs (2002)

In spite of their superior transport characteristics, InP HEMTs deliver lower output power than GaAs PHEMTs in the millimeter-wave regime. However, the superior power-added efficiency of InP HEMTs when compared with PHEMTs, makes this technology attractive for many applications. The reason for the lower power output of InP HEMTs is their relatively small off- and on-state breakdown voltage (BV). The authors review the state of knowledge regarding the physics of BV in InP HEMTs placing it in contrast with PHEMTs. They also discuss strategies for improving BV and the power output of InP HEMTs.
INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug (2013)

The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
Conditioned odor aversion induces social anxiety towards females in wild‐type and TrpC2 knockout male mice (2016)

Female-emitted pheromonal inputs possess an intrinsic rewarding value for conspecific males, promoting approach and investigation of the potential mating partner. In mice these inputs are detected mainly by the vomeronasal organ (VNO) and the main olfactory epithelium (MOE). We investigated the role of VNO-mediated inputs in experience-dependent plasticity of reproductive responses. We applied a sex-specific conditioned odor aversion (COA) paradigm on adult, wild-type (WT) male mice and on male mice impaired in VNO-mediated signal transduction (TrpC2<sup>-/-</sup> ). We found that WT males, which underwent COA to female-soiled bedding, lost their innate preference to female odors and presented lower motivation to approach a sexually receptive female. COA also abolished the testosterone surge normally seen following exposure to female odors. Moreover, the conditioned males displayed impairments in copulatory behaviors, which lasted for several weeks. Surprisingly, these males also exhibited phobic behaviors towards receptive females, including freezing and fleeing responses. In contrast, WT males which underwent COA specifically to male pheromones showed no change in olfactory preference and only a marginally significant elevation in intermale aggression. Finally, we show that TrpC2<sup>-/-</sup> males were able to acquire aversion to female-soiled bedding and presented similar behavioral alterations following COA in their responses to female cues. Our results demonstrate that the intrinsic rewarding value of female pheromones can be overridden through associative olfactory learning, which occurs independently of VNO inputs, probably through MOE signaling.
Subureteral Collagen Injection for the Endoscopic Treatment of Vesicoureteral Reflux in Children. Followup Study of 97 Treated Ureters and Histological Analysis of Collagen Implants (1992)

Endoscopic subureteral injection has become an established alternative means for treating vesicoureteral reflux in select children. However, which injection material to use remains a controversy. Polytetrafluoroethylene (Teflon) has been injected in more than a thousand patients with few complications, although experimental and clinical studies have demonstrated migration of the injected particles into distant organs, such as the lungs and the brain, as well as local and metastatic granuloma formation. Therefore, we introduced, following experimental studies in the mini-pig model, glutaraldehyde cross-linked, highly purified bovine collagen for injection. Between June 1988 and October 1991, 97 refluxing ureters in 66 children were treated by endoscopic subureteral collagen injection. In 58.8% of the ureters reflux was cured after 1 and in 77.3% after 2 injections. Considering improvement to grades I and II reflux without further treatment as success, the success rate increased to 68.0% after 1 and to 89.7% after 2 injections. Mean followup was 18.5 months (range 3 to 39 months). After 2 failed injections the patients either returned to antibiotic long-term prophylaxis or the reflux was operatively corrected. The operative procedure was never compromised by the preceding injection. A direct correlation between deficient length of the submucosal tunnel of the intravesical ureter and the iatrogenic malposition of the collagen deposits, and the failures could be demonstrated. Granuloma formation at the site of injection was not found. The results of the histological investigation of the collagen deposits removed at open ureteral reimplantation for failures are reported. It could be demonstrated that endogenous fibroblasts invade the bovine collagen implant and that these cells show active production of new human collagen, types I and III, replacing the implant.