gebhart/patrepeval huggingface dataset:
Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation, and a Hyperexcited State (2021)

The unique physicochemical properties of carbon nanomaterials and their ever-growing utilization generate a serious concern for occupational risk. Pulmonary exposure to these nanoparticles induces local and systemic inflammation, cardiovascular dysfunction, and even cognitive deficits. Although multiple routes of extrapulmonary toxicity have been proposed, the mechanism for and manner of neurologic effects remain minimally understood. Here, we examine the cerebral spinal fluid (CSF)-derived peptidomic fraction as a reflection of neuropathological alterations induced by pulmonary carbon nanomaterial exposure. Male C57BL/6 mice were exposed to 10 or 40 µg of multiwalled carbon nanotubes (MWCNT) by oropharyngeal aspiration. Serum and CSFs were collected 4 h post exposure. An enriched peptide fraction of both biofluids was analyzed using ion mobility-enabled data-independent mass spectrometry for label-free quantification. MWCNT exposure induced a prominent peptidomic response in the blood and CSF; however, correlation between fluids was limited. Instead, we determined that a MWCNT-induced peptidomic shift occurred specific to the CSF with 292 significant responses found that were not in serum. Identified MWCNT-responsive peptides depicted a mechanism involving aberrant fibrinolysis (fibrinopeptide A), blood-brain barrier permeation (homeobox protein A4), neuroinflammation (transmembrane protein 131L) with reactivity by astrocytes and microglia, and a pro-degradative (signal transducing adapter molecule, phosphoglycerate kinase), antiplastic (AF4/FMR2 family member 1, vacuolar protein sorting-associated protein 18) state with the excitation-inhibition balance shifted to a hyperexcited (microtubule-associated protein 1B) phenotype. Overall, the significant pathologic changes observed were consistent with early neurodegenerative disease and were diagnostically reflected in the CSF peptidome.
Review: Über das Schickliche. Studien zur Geschichte der Architekturtheorie 1 by Alste Horn-Oncken (1969)

Book Review| May 01 1969 Review: Über das Schickliche. Studien zur Geschichte der Architekturtheorie 1 by Alste Horn-Oncken Über das Schickliche. Studien zur Geschichte der Architekturtheorie 1Alste Horn-Oncken Wolfgang Herrmann Wolfgang Herrmann Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1969) 28 (2): 143–145. https://doi.org/10.2307/988514 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Wolfgang Herrmann; Review: Über das Schickliche. Studien zur Geschichte der Architekturtheorie 1 by Alste Horn-Oncken. Journal of the Society of Architectural Historians 1 May 1969; 28 (2): 143–145. doi: https://doi.org/10.2307/988514 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Copyright 1969 The Society of Architectural Historians Article PDF first page preview Close Modal You do not currently have access to this content.
“Strategic sequences” in adipose-derived stem cell nerve regeneration (2013)

hADSCs may play a key role in nerve regeneration by acting primarily as support for local neurotrophic mediation and modulation of nerve growth rather than that of a primary neuronal differentiation agent.
Fate of secretory proteins trapped in oocytes of Xenopus laevis by disruption of the cytoskeleton or by imbalanced subunit synthesis. (1981)

The effects of imbalanced subunit synthesis, temperature, colchicine, and cytochalasin on the secretion from Xenopus laevis oocytes of a variety of avian and mammalian proteins were investigated; these proteins were encoded by microinjected messenger RNA. Cytochalasin and colchicine together severely reduced secretion in a temperature-independent manner, the exact reduction varying among the different proteins. In contrast cytochalasin alone had no effect, whereas colchicine alone caused a smaller, temperature-dependent reduction. The synthesis and subcellular compartmentation of these proteins were unaffected by the drug treatments; however, the proteins did not accumulate in the drug-treated oocytes but were degraded. The rate of degradation of each protein was similar to its rate of exocytosis from untreated oocytes. A similar result was obtained without recourse to drugs by studying the fate of immunoglobulin light chains trapped in oocytes by a deficiency in heavy chain synthesis. These results are discussed in terms of the disruptive effects, as revealed by electron microscopy, of the drug treatments on the cytoskeleton of the oocyte.
Human-Assisted-Manufacturing Model Library (2012)

Abstract : Manufacturing process models are developed for a data-driven, reconfiguarable manufacturing facility. A human assembly process model is developed to characterize assembly processes. Machine and tool resources are characterized for manufacturing processes to provide a broad characterization of manufacturing process coverage in a hypothetical final assembly factory for infantry fighting vehicles. A sample population of manufacturing process parameters and resources is collected and incorporated into a manufacturing capability and process model library. Requirements for a virtual manufacturing environment are developed, and an initial, prototype version is implemented to facilitate process model validation, configuration, and experimentation.
Applicability of acoustic noise correlation for structural health monitoring in nondiffuse field conditions (2009)

Ambient noise correlation offers an elegant way of passively caracterize a medium. The principle is that in diffuse field condition, Green’s function between two sensors can be retrieved from the cross-correlated received signals. Here, the technique is applied in conditions where convergence toward Green’s function is not ensured. Since the obtained information is sensible to the medium state, it is still exploitable for damage detection provided a baseline version is available for comparison. This requires the identification of the acoustic source characteristics at the instant of measurement, which could be achieved using the signal measured at a “reference” sensor.
348 A Prospective Evaluation of Spray Keratinocytes to Treat Large TBSA Injuries (2018)

Over the last two decades, a decrease in mortality rates of burn patients can be attributed to continued advancements in burn resuscitation, intensive care, trauma care and nutritional support and early excision and coverage of the burn wound. However, patients with burns >50% TBSA continue to pose specific challenges to the burn surgeon with regards to autologus coverage due to their lack of donor sites. In September of 2016, we changed our practice with large TBSA burns by incorporating the use of spray keratinocytes (SK) over widely meshed autografts in conjunction with CEA to accelerate wound coverage. This study describes our experience using spray keratinocytes in this patient population. This is an on-going IRB approved prospective uncontrolled observational study evaluating clinical outcomes following the use of SK as an adjunct for closure in the treatment of life-threatening burn wounds, in patients who lack adequate available skin to harvest for conventional grafting. Following surgical excision and wound bed preparation through application of homograft, SK was used in combination with widely meshed STSGs, with a minimum ratio of 3:1, as well as for the treatment of donor sites. Data concerning clinical outcomes was collected through to the time of healing of all SK treated sites with 1 year follow-up. All adverse events associated with the use of SK were documented. Seven patients ranging from 3.9 to 61.8 years of age were treated with SK, with five subjects being less than 14 years old. Total body surface areas ranged from 43% to 95% with a mean of 60%. Collectively, 33 treatment sites and 15 donor sites were treated with SK, with a mean area of 2425.0 cm2 and 325.0 cm2, respectively. As part of the complete treatment regimen for these severely injured patients, four of seven also received CEA. Healing data at 4 weeks post-SK treatment was available for 31 of the 33 treatment sites and indicates that 93.5% of the wounds treated had ≥95% re-epithelialization. Two sites required additional treatment and the only adverse events reported were related to graft loss. Evaluation of donor site healing indicated that by week 1, 86.7% achieved ≥95% re-epithelialization, with two sites having 80% re-epithelialization. By 2 weeks post-treatment, both of these donor sites achieved closure. The use of SK has been successfully used as an adjunct to achieve earlier definitive wound closure for patients with extensive burn injuries allowing for a potentially decrease length of stay, decrease incidence of complication related to prolonged open wounds, and an earlier return to a homeostatic state. SK should be considered for use as part of a surgeon’s treatment algorithm for large TBSA injuries as it allows for greater wound coverage with less donor site.
Underwater high bit-rate optical free-space communication system (2012)

We present the design, realization and test of a high bit-rate optical communication system dedicated to underwater operations at the bottom of the sea transmitting data between sensor hubs and remote operated vehicles.
Effects of Ethanol Post-Fixation on the Histological, Histochemical, and Immunohistochemical Analysis of Murine Bone Specimens (2004)

Proper histological and histomorphometric assessment of bones requires acute visualization of cellular detail. Because fat is soluble in ethanol, adding an ethanol post-fixation step can help remove excess fat in tissue specimens, thus enhancing cellular visualization. However, the effects of adding this additional ethanol post-fixation step on bone-specific histochemical and immunohistochemical protocols have not yet been elucidated. Here, we describe the differences between using or not using an additional ethanol post-fixation step on six types of histochemical and immunohistochemical protocols. We assessed the effects in undecalcified tibiae sections routinely stained with hematoxylin and eosin, toluidine blue, and Von Kossa and found that addition of ethanol post-fixation enhanced specimen visualization for each of these stains. We examined the of ethanol post-fixation on enzymatic staining and found that alkaline phosphatase activity was equally preserved, whereas acid phosphatase activity was visualized more readily in specimens that underwent this treatment. Finally, the ethanol post-fixation improved antigen preservation in osteocalcin immunohistochemical labeling. (The J Histotechnol 27: 15, 2004)Submitted: July 8, 2003; Accepted: October 31, 2003
Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes (2000)

Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters in the brain. The colocalization of their respective biosynthetic enzymes, neuronal NO synthase (nNOS) and heme oxygenase-2 (HO2), in enteric neurons and altered intestinal function in mice with genomic deletion of the enzymes ( nNOS Δ/Δ and HO2 Δ/Δ ) suggest neurotransmitter roles for NO and CO in the enteric nervous system. We now establish that NO and CO are both neurotransmitters that interact as cotransmitters. Small intestinal smooth muscle cells from nNOS Δ/Δ and HO2 Δ/Δ mice are depolarized, with apparent additive effects in the double knockouts ( HO2 Δ/Δ / nNOS Δ/Δ ). Muscle relaxation and inhibitory neurotransmission are reduced in the mutant mice. In HO2 Δ/Δ preparations, responses to electrical field stimulation are nearly abolished despite persistent nNOS expression, whereas exogenous CO restores normal responses, indicating that the NO system does not function in the absence of CO generation.
Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy (2022)

With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized.
Geometric Transformation Techniques for Digital Images: A Survey (1988)

This survey presents a wide collection of algorithms for the geometric transformation of digital images. Efficient image transformation algorithms are critically important to the remote sensing, medical imaging, computer vision, and computer graphics communities. We review the growth of this field and compare all the described algorithms. Since this subject is interdisciplinary, emphasis is placed on the unification of the terminology, motivation, and contributions of each technique to yield a single coherent framework. This paper attempts to serve a dual role as a survey and a tutorial. It is comprehensive in scope and detailed in style. The primary focus centers on the three components that comprise all geometric transformations: spatial transformations, resampling, and antialiasing. In addition, considerable attention is directed to the dramatic progress made in the development of separable algorithms. The text is supplemented with numerous examples and an extensive bibliography.
Mesoscale model performance with assimilation of wind profiler data: Sensitivity to assimilation parameters and network configuration (2007)

The performance of the nudging scheme in the MM5 numerical model is evaluated for a 4‐day simulation of an ozone episode during the TexAQS‐2000 field study. Quality‐controlled horizontal wind data from five boundary layer profilers spaced 30–50 km apart are used as input data for the nudging as well as for quantification of model errors. Observations from selected profilers are withheld to provide independent data to evaluate the performance of the model. A series of experiments are conducted to estimate the overall model performance as well as the dependence of the model performance on nudging parameters and on profiler network configuration. Within the profiler network, nudging generally reduces 4‐day average biases in the wind components to less than 0.3 m s −1 and yields rms errors averaging 1.75 m s −1 to 2.08 m s −1 , with the best model performance at about 500–1500 m above ground level. Rms errors without data assimilation are about twice as large. Model errors, with and without assimilation, are generally largest at night. Wind fields that are more accurate in a statistical sense can be obtained by simpler analysis schemes, but the consistent dynamical evolution of all meteorological variables, such as the pattern of temperatures associated with corrected sea breeze location and intensity, are lost. Tests with a reduced profiler network showed that a single profiler in an appropriate upstream location can produce model performance equivalent to that from a four‐profiler network surrounding the validation station.
Full-field optical coherence tomography with thermal light (2002)

A simple optical coherence tomography system has been developed based on a white-light Linnik interferometric microscope with its reference mirror mounted on a piezoelectric translator. The geometrical extension of the optics allows efficient illumination of this device with a low-power (3-W) light bulb, yielding full-field interferometric images at 50 Hz with a fast CCD camera. Owing to the very broad spectral width of the light source and of the camera response, we achieved axial resolutions equal to 1.1 microm in free space and 0.7 microm through a standard microscope cover plate. Tomographic images of an epithelial cell smear and of an hematological sample are shown.
Regenerative medicine: When are the therapies going to arrive? (2015)

The field of regenerative medicine is moving very quickly across a broad range of indications using a wide variety of cell types and drugs. The areas attracting most interest are cell therapies, tissue engineering and endogenous stem cell mobilisation. Perhaps the most interest presently is in the discovery of drugs and monoclonal antibodies for destroying cancer stem cells, gene editing of adult stem cells for genetic disease and the rapid escalation of companies involved in chimeric antigen receptor technology (CAR-T) being used to genetically arm Killer T cells (CD8+) to rapidly destroy blood and solid tumours.
Current Applications of Digital Subtraction Angiography in Clinical Neuroradiology (1982)

Digital subtraction angiography (DSA) has replaced standard angiography in the preoperative evaluation of patients with pituitary adenomas and is superior to standard angiography in the evaluation of the dural sinuses. Postoperative assessment of intracranial aneurysms, arteriovenous malformations and grafts has also been accomplished by DSA. In addition, the DSA technique may be utilized in conjunction with intraarterial injections of contrast material to reduce film cost and increase patient comfort.
Assembly product (viral contigs and MAGs) (2023)

Assembly product (viral contigs and MAGs) includes the dereplicated viral contigs and the finalized MAGs
Influence of vitamins A, C, and E and β-carotene on aflatoxin B1 binding to DNA in woodchuck hepatocytes (1994)

These results demonstrate that micronutrients play a complex role in the process of chemical carcinogenesis. Although protective effects were seen with several antioxidant vitamins, increased DNA adduct formation was observed with beta-carotene and vitamin E. This antioxidant activity may be unrelated to the inhibition of DNA adduct formation. Additional studies are needed to understand the mechanism of enhanced adduct formation.
Studies on the constituents of asclepiadaceae plants. XLVI. Aglycones from Stephanotis japonica Makino. (1979)

In addition to stephanthraniline A and stephanthraniline C, whose structures have been reported previously, five new pregnane derivatives, stephanthraniline B (12β-O, N-methyl-anthraniloyl-20-O-acetyldihydrosarcostin), SG-A (12β-O-(2-methylbutyryl)-20-O-acetylsarcostin), SG-B (20-O-(2-methylbutyryl) sarcostin), SG-C (20-O-tigloylsarcostin), and dihydrogagaminin (12β-O-cinnamoyl-20-O-nicotinoyl-dihydrosarcostin) were isolated from the aerial parts of Stephanotis japonica MAKINO (Asclepiadaceae) and their structures were determined. Penupogenin, kidjoranin, and gagaminin were also isolated and identified.
Visualizing flow over curvilinear grid surfaces using line integral convolution (1994)

Line Integral Convolution (LIC), introduced by Cabral and Leedom in Siggraph '93, is a powerful technique for imaging and animating vector fields. We extend the LIC paradigm in three ways:1. The existing technique is limited to vector fields over a regular Cartesian grid. We extend it to vector fields over parametric surfaces, specifically those found in curvilinear grids, used in computational fluid dynamics simulations.2. Periodic motion filters can be used to animate the flow visualization. When the flow lies on a parametric surface, however, the motion appears misleading. We explain why this problem arises and show how to adjust the LIC algorithm to handle it.3. We introduce a technique to visualize vector magnitude as well as vector direction. Cabral and Leedom have suggested a method for variable-speed animation, which is based on varying the frequency of the filter function. We develop a different technique based on kernel phase shifts which we have found to show substantially better results.Our implementation of these algorithms utilizes texture-mapping hardware to run in real time, which allows them to be included in interactive applications.
Self-guiding and red shifts of intense pulses propagating in clustered gases (2004)

Summary form only given. Intense laser interaction with clusters, Van der Waals-bonded aggregates of up to /spl sim/10/sup 7/ atoms, is of great interest owing to applications which include the generation of X-rays, energetic ions and electrons, and nuclear particles. In recent work, the time-resolved explosion of intense-laser-heated clusters has been observed, and this explosion scenario leads to intense laser self-focusing in a clustered gas. Here, we report measurements of the frequency shifts of intense laser pulses propagating in clustered gases. This measurement is consistent with our previous observations and model. We use a pump-probe setup for the frequency shift measurement. For a series of time-delayed 2/spl omega/ probe (sub-80 fs, 399 nm) spectra modulated by an intense pump (1.5 mJ, 80 fs, 798 nm) pulse co-propagating in a gas of argon clusters, we find that the probe increasingly red-shifts during the phase where the pump self-focuses. At later times, the shift goes blue and then relaxes back to zero. The red-shifts at early delays indicate the positive transients of the refractive index of pump-heated clusters, in agreement with our recent observation of self-focusing. This red-shift strongly contrasts with the blue-shift commonly observed in the ionization of non-clustered gases. At later times, however, the probe frequency shift becomes blue and then relaxes to zero owing to the dominant response of the underdense portion of the cluster plasmas at later times, with that response becoming progressively weaker.