gebhart/patrepeval huggingface dataset:
Structural, Spectroscopic, and Magnetochemical Characterization of the Trinuclear Vanadium(III) Carboxylates [V3O(O2CR)6L3](ClO4) (R = Various Groups; L = Pyridine, 4-Picoline, 3,5-Lutidine) (1996)

Synthetic procedures are described that allow access to the [V(3)O(O(2)CR)(6)L(3)](ClO(4)) (R = various groups; L = pyridine (py), 4-picoline (pic) or 3,5-lutidine (lut)) family of complexes. Treatment of VCl(3)(THF)(3) with NaO(2)CR (R = Me, Et) in RCO(2)H/py, pic/MeCN, or CH(2)Cl(2) solution followed by addition of NBu(n)(4)ClO(4) leads to isolation of [V(3)O(O(2)CR)(6)L(3)](ClO(4)) salts in 47-95% yields. A similar procedure for R = C(6)H(5), C(6)H(4)-p-OMe, C(6)H(3)-m-Me(2), and C(6)H(4)-p-Cl but omitting addition of NaO(2)CR provides the corresponding benzoate or substituted-benzoate derivatives in 24-56% yields. The X-ray structure of [V(3)O(O(2)CEt)(6)(pic)(3)](ClO(4)) (4) shows the anion to consist of a [V(3)O](7+) triangular fragment with a &mgr;(3)-O(2)(-) ion in the V(3) plane; each triangular edge is bridged by two EtCO(2)(-) groups in their familiar syn,syn modes, and there is a terminal pic group on each V(III) completing distorted octahedral geometries at the metal atoms. The cation has imposed C(2) symmetry (isosceles V(3) triangle), the C(2) axis passing through one V atom and the central &mgr;(3)-O atom, but has D(3)(h)() virtual symmetry (equilateral V(3) triangle). Complex 4 crystallizes in monoclinic space group C2/c with the following unit cell dimensions at -171 degrees C: a = 13.935(2) Å, b = 18.323(2) Å, c = 17.470(2) Å, beta = 95.55(1) degrees, V = 4439.7 Å(3), Z = 4. The structure was solved using 2657 unique reflections with F > 3sigma(F) and refined on F to conventional R (R(w)) values of 0.058 (0.066). Variable-temperature, solid-state magnetic susceptibility measurements were made on complex 1 in the 5.01-280 K region in a 1 kG magnetic field. The effective magnetic moment (&mgr;(eff)) per V(3) unit decreases gradually from 4.64 &mgr;(B) at 280 K to 1.76 &mgr;(B) at 5.01 K. The data were fit to the theoretical expression for an isosceles V(III)(3) complex, and the fitting parameters were J = -18.0(7) cm(-)(1), J' = -10.4(4) cm(-)(1), and g = 1.985, with TIP held constant at 600 x 10(-)(6) cm(3) mol(-)(1); J' refers to the unique exchange interaction within the isosceles triangle. The ground state of complex 1 thus has S = 0.
Changes in patient health questionnaire (PHQ-9) scores in adults with medical authorization for cannabis (2020)

Although the majority showed no clinically important changes in PHQ-9 scores, a number of patients showed improvement or deteriorations in PHQ-9 scores. Future studies should focus on the parallel use of screening questionnaires to control for PHQ-9 sensitivity and to explore potential factors that may have attributed to the improvement in scores pre- and post- 3-6 month time period.
Pineapple Fiber Hybrids Prepared by the Fusion of radiation-induced Graft Polymerization and Kabachnik-Fields three-component Reaction (RIGP-KF3CR) (2022)

The fusion of multicomponent reactions and polymer chemistry allows the synthesis of polymeric materials that contain special classes of molecules that are otherwise difficult to produce. In this study, a locally available nonwoven fabric composed of pineapple fibers and polylactic acid (piñatex) was modified by radiation-induced graft polymerization (RIGP) of vanillin methacrylate, a lignin-derived monomer. RIGP yielded organic hybrids made from a natural, renewable, and biodegradable substrate, and surface aldehyde groups from vanillin. The grafted fabric was prepared by gamma pre-irradiation at 50 kGy, exhibiting an increasing degree of grafting with increasing reaction time and monomer concentration. Post-polymerization modification carried out using Kabachnik-Fields three-component reaction (KF3CR) enabled the immobilization of amine and phosphite moieties on the fabric. FTIR, SEM-EDS and XPS analysis of 8 amine and phosphite combinations showed the presence of the corresponding elements and functional groups, indicating successful surface functionalization through RIGP-KF3CR. All modified natural fibers-based fabrics displayed enhanced thermal stability without obvious radiation degradation effects. Synthesized natural fibers contain α-aminophosphonate pendants which may be useful in the selective adsorption and recovery of industry valuable metals.
Experiments on Steel MRF Building with Supplemental Tendon System (2000)

An experimental and analytical study is presented that investigates the effectiveness of a supplemental damping system consisting of elastomeric spring dampers (ESD) and fuse-bars to mitigate the seismic response of steel structures. Steel structures generally possess significant flexibility and relatively low inherent viscous damping. Under strong earthquake ground shaking, large interstory drifts can be expected which in turn cause distress to both structural and nonstructural elements. In this study, a load-balancing tendon fuse+damper (TFD) system has been adopted, where sacrificial yielding fuse-bars are used parallel to ESD devices to initially help stiffen the structure. A total of seven different configurations were tested with various bracing as well as supplemental damping systems. It was both experimentally observed and analytically shown that the proposed supplemental tendon system significantly attenuates the overall seismic response of the structure. An improved velocity-dependent computational model for the ESD devices is presented and verified. Hence, benefits of using a load balancing–draped tendon profile are analytically investigated.
Crack blunting and the strength of soft elastic solids (2003)

When a material is so soft that the cohesive strength (or adhesive strength, in the case of interfacial fracture) exceeds the elastic modulus of the material, we show that a crack will blunt instead of propagating. Large–deformation finite–element model (FEM) simulations of crack initiation, in which the debonding processes are quantified using a cohesive zone model, are used to support this hypothesis. An approximate analytic solution, which agrees well with the FEM simulation, gives additional insight into the blunting process. The consequence of this result on the strength of soft, rubbery materials is the main topic of this paper. We propose two mechanisms by which crack growth can occur in such blunted regions. We have also performed experiments on two different elastomers to demonstrate elastic blunting. In one system, we present some details on a void growth mechanism for ultimate failure, post–blunting. Finally, we demonstrate how crack blunting can shed light on some long–standing problems in the area of adhesion and fracture of elastomers.
Effects of Intrathecal mu, delta, and kappa Agonists on Thermally Evoked Cardiovascular and Nociceptive Reflexes in Halothane-Anesthetized Rats (1995)

Despite significant opioid binding in the intermediolateral cell column, the effects of intrathecal injections of mu, delta, and kappa opioid agonists on the cardiovascular response to noxious stimulation have not been examined systematically.The pharmacology of intrathecally administered opioid agonists {mu, morphine, [D-Ala (2),N-MePhe4,Gly5-ol]enkephalin (DAGO); delta, metkephamid, [D-Ala2-D-Leu5]enkephalin (DADL), [D-Pen2,D-Pen5]enkephalin (DPDPE); kappa, U50488H and PD117,302} or agonist-antagonist (nalbuphine) on somatomotor (tail-flick) and cardiovascular changes (blood pressure and heart rate) evoked by immersing the tail in 53 degrees C water were examined in rats anesthetized with halothane (0.75%) and in which intrathecal catheters had been chronically implanted. Intrathecal administration of mu and delta, but not kappa agonists or agonist-antagonist produced a dose-dependent block of tail-flick and evoked cardiovascular responses with the order of activity being as follows: DAGO > metkephamid DADL > morphine > DPDPE ≫ nalbuphine = PD117,302 = U50488H = 0. These effects were reversed readily by the opioid antagonist naloxone. In addition, intrathecal administration of mu and delta but not kappa or agonist-antagonist had little effect on resting heart rate and blood pressure. These data indicate that the agonist occupancy of spinal mu and delta, but not kappa agonists can profoundly modulate the autonomic and somatomotor response evoked by high threshold thermal stimuli. (Anesth Analg 1995;80:437-43)
With or without You: Co-Chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein Triage (2021)

Heat shock proteins (HSPs) are a family of molecular chaperones that regulate essential protein refolding and triage decisions to maintain protein homeostasis. Numerous co-chaperone proteins directly interact and modify the function of HSPs, and these interactions impact the outcome of protein triage, impacting everything from structural proteins to cell signaling mediators. The chaperone/co-chaperone machinery protects against various stressors to ensure cellular function in the face of stress. However, coding mutations, expression changes, and post-translational modifications of the chaperone/co-chaperone machinery can alter the cellular stress response. Importantly, these dysfunctions appear to contribute to numerous human diseases. Therapeutic targeting of chaperones is an attractive but challenging approach due to the vast functions of HSPs, likely contributing to the off-target effects of these therapies. Current efforts focus on targeting co-chaperones to develop precise treatments for numerous diseases caused by defects in protein quality control. This review focuses on the recent developments regarding selected HSP70/HSP90 co-chaperones, with a concentration on cardioprotection, neuroprotection, cancer, and autoimmune diseases. We also discuss therapeutic approaches that highlight both the utility and challenges of targeting co-chaperones.
Methods to Characterize the Dispersability of Carbon Nanotubes and Their Length Distribution (2012)

Abstract Es werden zwei Eigenschaften von Carbon Nanotube (CNT)‐Materialien näher untersucht. Zum einen wird eine Methode zur Charakterisierung der Dispergierbarkeit von CNT‐Materialien in wässrigen Tensid‐Lösungen vorgestellt, aus der auch Schlussfolgerungen zur Dispergierbarkeit in anderen Medien, wie Polymerschmelzen, gezogen werden können. Zum anderen wird gezeigt, wie die Länge von CNTs vor und nach der Verarbeitung, z. B. nach Schmelzemischen mit Thermoplasten, quantifiziert werden kann. Beide Methoden werden mit Beispielen unterlegt und die praktische Relevanz aufgezeigt.
Advanced model order reduction and artificial intelligence techniques empowering advanced structural mechanics simulations: application to crash test analyses (2019)

This paper proposes a general framework for expressing parametrically quantities of interest related to the solution of complex structural mechanics models, in particular the ones involved in crash analyses where strongly coupled nonlinear and dynamic behaviors coexist with space-time localized mechanisms. Advanced nonlinear regressions able to proceed in the low-data limit, enabling to accommodate heterogeneous parameters, will be proposed and their performances evaluated in the case of crash simulations. As soon as these parametric expressions will be determined, they can be used for generating large amounts of realizations of the quantity of interest for different choices of the parameters, for supporting data-analytics. On the other hand, such parametric representations allow the use advanced optimization techniques, evaluate sensitivities and propagate uncertainty all them under the stringent real-time constraint.
The use of sewage sludge as manure for plant crops: a study of <i>Spinacia oleracea</i> accumulation of heavy metals and heavy metal bio-available fractions fertilised by sewage sludge (2019)

Spinach vegetables (Spinacia oleracea) were planted and dry sludge was applied as manure. At maturity, samples of the leaves were taken. The soil, sludge and leaf samples were analysed for total heavy metal content (Cr, Cu, Fe, Mn, Zn, Cd, Co, Ni, Pb and Al) using ICP/OES. Leaf samples were also analysed for the different forms or species of heavy metals. Cu was found to have the lowest concentration (0.0009 mg kg−1) while Fe registered the highest concentration (378.9 mg kg−1). The speciated heavy metals were found to have their highest concentration at 136.8 mg kg−1 for the exchangeable fraction (F1) of Fe metal and the lowest concentration of 0.0005 mg kg−1 for the residual fraction (F5) of Pb metal. The Study revealed that there is a possibility of an uptake of heavy metals by the vegetable leaves from the sludge through the soil.
ChemInform Abstract: PIPERIDONES AS POTENTIAL ANTICANCER AGENTS (1975)

Abstract Aus p‐Phenylazosalicylaldehyd (I), den Ketonen (II) und Ammoniumacetat entstehen die 4‐Piperidone (III).
Inducible Nitric Oxide Synthase-Mediated Alteration of Mitochondrial OPA1 Expression in Ocular Hypertensive Rats (2011)

Although NOS-2/NO induction may contribute to hypertensive retinal cell death, an increase in mitochondrial OPA1 may provide an important cellular defense mechanism against pressure-mediated retinal damage. These findings suggest that mitochondrial preservation after inhibition of NOS-2 may be useful for protecting RGCs against glaucomatous damage.
A single-chip controller for digital answering machines (1993)

A single-chip controller for digital answering machines is introduced. Only two other devices, an audio quality DRAM (ARAM) and a codec, are needed to implement all the digital parts of such an answering machine. The device performs voice compression and decompression algorithms, dual-tone multifrequency (DTMF) detection, voice synthesis, and control functions of digital answering machines.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Global detection approach for clustered microcalcifications in mammograms using a deep learning network (2017)

In computerized detection of clustered microcalcifications (MCs) from mammograms, the traditional approach is to apply a pattern detector to locate the presence of individual MCs, which are subsequently grouped into clusters. Such an approach is often susceptible to the occurrence of false positives (FPs) caused by local image patterns that resemble MCs. We investigate the feasibility of a direct detection approach to determining whether an image region contains clustered MCs or not. Toward this goal, we develop a deep convolutional neural network (CNN) as the classifier model to which the input consists of a large image window ([Formula: see text] in size). The multiple layers in the CNN classifier are trained to automatically extract image features relevant to MCs at different spatial scales. In the experiments, we demonstrated this approach on a dataset consisting of both screen-film mammograms and full-field digital mammograms. We evaluated the detection performance both on classifying image regions of clustered MCs using a receiver operating characteristic (ROC) analysis and on detecting clustered MCs from full mammograms by a free-response receiver operating characteristic analysis. For comparison, we also considered a recently developed MC detector with FP suppression. In classifying image regions of clustered MCs, the CNN classifier achieved 0.971 in the area under the ROC curve, compared to 0.944 for the MC detector. In detecting clustered MCs from full mammograms, at 90% sensitivity, the CNN classifier obtained an FP rate of 0.69 clusters/image, compared to 1.17 clusters/image by the MC detector. These results indicate that using global image features can be more effective in discriminating clustered MCs from FPs caused by various sources, such as linear structures, thereby providing a more accurate detection of clustered MCs on mammograms.
Genetic Analysis and Mapping of Dominant Minute Grain Gene Mi3（t） in Rice (2005)

Grain size, determined chiefly by grain Iength, is one of the main factors affecting the grain yield in rice production. To study the trait of rice grain size, F1 and F2 populations were developed from crosses Shuhui 881/Y34 and Shuhui 527/Y34, and genetic analysis for minute grain was performed. The F1 populations showed minute grains, and grain size segregations in the two F2 populations were both in accordance with the ratio of 3:1, indicating that minute grain in Y34 was controlled by a completely dominant gene. By using the F2 population from Shuhui 881/Y34, this dominant gene, tentatively designated as Mi3(t), was mapped based on SSR markers in the interval between RM282 (genetic distance of 5.1 cM) and RM6283 (genetic distance of 0.9 cM) on the short arm of chromosome 3.
A phase II open labeled, randomized study of poly-ICLC matured dendritic cells for NY-ESO-1 and Mean-A peptide vaccination compared to Montanide, in melanoma patients in complete clinical remission. (2019)

9538 Background: Dendritic cells (DC) play a critical role in tumor immune-surveillance. Combination therapies by utilizing check point inhibitors may revert tumor-induced-T cell exhaustion; however, DCs are necessary to prime/activate T cells to target tumor cells. Montanide is a mineral oil-based adjuvant that enhances the immune response to vaccination. In this study, we compared the immunogenicity of Montanide and poly-ICLC-matured DCs. Methods: This is a Phase II open label, randomized two arm study to compare Poly-ICLC matured DC with systemic administration of Poly-ICLC on days 1 and 2 (ARM A) to Montanide ISA-51 and Poly-ICLC as adjuvants for NY-ESO-1 and Melan-A/MART-1 peptide vaccination with systemic administration of Poly-ICLC on day 2 (ARM B) in study subjects with melanoma in complete clinical remission but at high risk of disease recurrence (NCT02334735). Evaluation of primary tumor expression of NY-ESO-1 and Melan-A tumor was determined by immunohistochemistry (IHC). Humoral responses were assessed by Seromics (ELISA) and T-cell responses were performed ex-vivo by interferon (IFN)-g enzyme-linked immunospot assay (ELISPOT) and after expansion by intracellular cytokine staining (ICS). Results: Twenty-nine patients have been enrolled in this study. IHC studies demonstrated tumor expression of NY-ESO-1 and Melan-A in 78% and 81% of the patients, respectively. 100% of patients within arm B became seropositive for NY-ESO-1 peptide by cycle 2 day 8 (C2D8). 80% of patients within arm A also seroconverted to this antigen but titers were significantly lower. Melan-A-specific antibody responses were also found in arm B patients, but to a lesser degree. However, arm A patients failed to develop seroreactivity to Melan-A. Cellular responses are under analysis. Preliminary data show that subjects in both arms develop T cell responses to both antigens. Conclusions: This vaccine trial reached the primary endpoint of safety and tolerability. Patients vaccinated with either DC or Montanide had demonstrable antibody titers to immunizing antigens, although the latter reproducibly induced higher titers. Evaluation of cellular responses is ongoing. Clinical trial information: NCT02334735.
Molecular cloning and characterization of hemicholinium-3-sensitive choline transporters (2001)

Conference Abstract| October 01 2001 Molecular cloning and characterization of hemicholinium-3-sensitive choline transporters S. Apparsundaram; S. Apparsundaram 1Dept. of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536-0098, USA Search for other works by this author on: This Site PubMed Google Scholar S.M. Ferguson; S.M. Ferguson 2Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, TN 3232-3420, USA Search for other works by this author on: This Site PubMed Google Scholar R.D. Blakely R.D. Blakely 2Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, TN 3232-3420, USA Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 2001 Biochemical Society2001 Biochem Soc Trans (2001) 29 (5): A95. https://doi.org/10.1042/bst029a095a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation S. Apparsundaram, S.M. Ferguson, R.D. Blakely; Molecular cloning and characterization of hemicholinium-3-sensitive choline transporters. Biochem Soc Trans 1 October 2001; 29 (5): A95. doi: https://doi.org/10.1042/bst029a095a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2001 Biochemical Society2001 Article PDF first page preview Close Modal You do not currently have access to this content.
Reality Bites: Employment Policy in a Measurement Vacuum (2002)

The recovery from the recession of the 1990s has been accompanied by continual restructuring of the South Australian economy. Consequently, the South Australian labour market has deteriorated structurally, making it particularly vulnerable to externals shocks. The official unemployment rate in South Australia has ratcheted upwards over the past two business cycles to a cyclical low of 6.6 per cent, compared to 5.8 per cent nationally. Not surprisingly, the South Australian Government has targeted employment growth as a policy priority. However, evidence suggests that the extent of hidden unemployment in South Australia has been substantially underestimated and so the nature of the public policy response to the unemployment problem in South Australia may need to be revised. The aim of this paper is to develop a more appropriate measure of hidden unemployment and then calculate the real unemployment rate in order to provide a more appropriate basis for employment policy.
A Concise Enantio- and Stereocontrolled Synthesis of (+)-Ramulosin from (R)-O-Benzylglyidol (1989)

Ramulosin, a metabolite of Pestolatia ramulose, has been synthesized in enantio- and stereocontrolled fashion starting from (R)-O-benzylglycidol
Synthesis and characterisation of Ca1-xCexZrTi2-2xCr2xO7: Analogue zirconolite wasteform for the immobilisation of stockpiled UK plutonium (2020)

A series of Ca1-xCexZrTi2-2xCr2xO7 zirconolite ceramics (0 ≤ x ≤ 0.35) were reactively sintered in air at 1350 °C for 20 h. Single phase zirconolite-2M was formed for x ≤ 0.15, with Cr2O3 and an undesirable Ce-bearing perovskite phase present above x = 0.20. Electron diffraction analysis confirmed that the zirconolite-2M polytype was maintained over the solid solution. X-ray absorption near edge structure (XANES) data determined that between 10–20% Ce was speciated as Ce3+, and Cr was present uniformly as Cr3+ with near edge features consistent with occupation of octahedral sites within the zirconolite-2M structure. A sample corresponding to x = 0.20 was processed by reactive spark plasma sintering (RSPS), with a rapid processing time of less than 1 h. XANES data confirmed complete reduction to Ce3+ during RSPS, promoting the formation of a Ce-bearing perovskite, comprising 19.3 ± 0.4 wt. % of the phase assemblage.