gebhart/patrepeval huggingface dataset:
P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm (1995)

P13suc1 sepharose-conjugated beads were used to extract the kinases that phosphorylate neurofilaments in the squid giant axon. Using Western blots and in vitro kinase assays, we demonstrated the presence of an active cdc2-like kinase and its putative regulators such as cyclin E, p13, and p67 in axoplasm and a P13-axoplasm complex (P13-Ax). Protein kinase A (PKA) and casein kinase (CK) I and II were also found in the P13-Ax. Western blot analysis of the P13-Ax also demonstrated several axonal cytoskeletal components; e.g., neurofilaments (NFs; NF 60, 70, and 220), tubulin, actin, and microtubule-associated proteins. NF 220 and tubulin were phosphorylated by the kinases in the P13-Ax. To determine whether NFs bound directly to the P13 beads, or bound indirectly by association with cdc2 kinase, a washed, axon-derived neurofilament preparation that contained NFs, PKA, CKl, and tubulin, but no cdc2-like kinase, yielded no bound proteins after incubation with P13suc1. The wash supernatant from the neurofilament preparation, however, containing the cdc2-like kinase, did yield cytoskeletal components that bound to P13suc1. Moreover, a bacterial-expressed cdk5 associated with P13 beads was able to complex with selected cytoskeletal components in the washed neurofilament preparation. These data indicate that direct binding of P13 beads with a cdc2-like kinase could extract active multimeric complexes composed of axonal cytoskeletal proteins and kinases. Application of P13 chromatography may be useful in characterizing the network of functional interactions among cytoskeletal elements and protein kinases in neurons.
ChemInform Abstract: Potential Antisecretory Antidiarrheals. Part 2. α2‐Adrenergic 2‐((Aryloxy)alkyl)imidazolines. (1990)

Abstract The bromo ester (I) is coupled with the phenols (II) to produce the corresponding α‐phenoxy esters (III) which are transformed into the imidazolines (V) mentioned in the title by cyclocondensation with the diamines (IV).
Somatic Symptoms as Predictors of Time to Onset of Response to Fluoxetine in Major Depressive Disorder (2004)

Somatic symptoms of depression were found to be associated with a delayed onset of antidepressant response to fluoxetine in MDD.
Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains (2015)

The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three primary domains: a charged N terminus that binds heparan sulfate proteoglycans, a central NANP repeat domain, and a C terminus containing a thrombospondin-like type I repeat (TSR) domain. Only the last two domains are incorporated in RTS,S, the leading malaria vaccine in phase 3 trials that, to date, protects about 50% of vaccinated children against clinical disease. A seroepidemiological study indicated that the N-terminal domain might improve the efficacy of a new CSP vaccine. Using a panel of CSP-specific monoclonal antibodies, well-characterized recombinant CSPs, label-free quantitative proteomics, and in vitro inhibition of sporozoite invasion, we show that native CSP is N-terminally processed in the mosquito host and undergoes a reversible conformational change to mask some epitopes in the N- and C-terminal domains until the sporozoite interacts with the liver hepatocyte. Our findings show the importance of understanding processing and the biophysical change in conformation, possibly due to a mechanical or molecular signal, and may aid in the development of a new CSP vaccine.
Zu Aristophanes, Frösche 165f (1997)

Bevor Dionysos und sein Sklave Xanthias die abwechslungsreiche und gefahrvolle Reise in die Unterwelt auf sich nehmen, suchen sie Herakles auf, der von Dionysos über 140 Verse hinweg nach möglichen Reiserouten und nützlichen Hinweisen befragt wird1. Dieses Gespräch knüpft offensichtlich an die Tradition der Befragung von Sehern und Weisen durch einzelne oder mehrere Heroen an: so verfahren die Argonauten bei Phineus, Menelaos bei Proteus oder Odysseus bei dem schon verstorbenen Teiresias in der Nekyia2.
Extracting library-based object-oriented applications (2000)

In an increasingly popular model of software distribution, software is developed in one computing environment and deployed in other environments by transfer over the internet. Extraction tools perform a static whole-program analysis to determine unused functionality in applications in order to reduce the time required to download applications. We have identified a number of scenarios where extraction tools require information beyond what can be inferred through static analysis: software distributions other than complete applications, the use of reflection, and situations where an application uses separately developed class libraries. This paper explores these issues, and introduces a modular specification language for expressing the information required for extraction. We implemented this language in the context of Jax , an industrial-strength application extractor for Java, and present a small case study in which different extraction scenarios are applied to a commercially available library-based application.
Fuel-Ash Corrosion and Its Effect on Boiler Design (1965)

Problems inherent in boiler design owing to the phenomenon of high-temperature oil and coal-ash corrosion are reviewed. Experience and research are discussed, together with the design philosophies and procedures used by the authors’ company in the design of boiler units to alleviate, or minimize, the possibility of high-temperature corrosion. Practical corrective measures to protect boiler units encountering corrosion are noted, and laboratory and field investigations now underway to learn more about the fundamental mechanism of corrosion are described briefly.
Regulation of RhoA-dependent ROCKII activation by Shp2 (2008)

Contractile forces mediated by RhoA and Rho kinase (ROCK) are required for a variety of cellular processes, including cell adhesion. In this study, we show that RhoA-dependent ROCKII activation is negatively regulated by phosphorylation at a conserved tyrosine residue (Y722) in the coiled-coil domain of ROCKII. Tyrosine phosphorylation of ROCKII is increased with cell adhesion, and loss of Y722 phosphorylation delays adhesion and spreading on fibronectin, suggesting that this modification is critical for restricting ROCKII-mediated contractility during these processes. Further, we provide evidence that Shp2 mediates dephosphorylation of ROCKII and, therefore, regulates RhoA-induced cell rounding, indicating that Shp2 couples with RhoA signaling to control ROCKII activation during deadhesion. Thus, reversible tyrosine phosphorylation confers an additional layer of control to fine-tune RhoA-dependent activation of ROCKII.
Reduced ABCA1-Mediated Cholesterol Efflux and Accelerated Atherosclerosis in Apolipoprotein E–Deficient Mice Lacking Macrophage-Derived ACAT1 (2005)

Deficiency of macrophage ACAT1 accelerates atherosclerosis in hypercholesterolemic apoE-/- mice but has no effect when the hypercholesterolemia is corrected by macrophage apoE expression. However, ACAT1 deletion impairs ABCA1-mediated cholesterol efflux in macrophages regardless of apoE expression. Changes in membrane stability, susceptibility to apoptosis, and inflammatory response may also be important in this process.
El tratamiento televisivo en programas musicales especializados de la música popular y las mujeres. Panorama de las cadenas generalistas de TDT España (2010)

El presente trabajo pretende ofrecer un estado de la cuestion de la posibilidades del videoclip como herramienta del feminismo y la superacion del genero han sido objeto de estudio investigacion sobre la representacion de las mujeres en programas televisivos de contenido exclusivamente musical, a traves de la revision bibliografica de estudios que se han acercado a esta problematica, desde distintos ambitos cientificos
 desde los anos 1980 en adelante. El estudio de las mujer es en la television musical se ha abordado mayoritariamente con atencion al formato del videoclip, que ha fascinado a teoricos de diversas disciplinas desde su aparicion en la decada de los 1980. Debido a esta circunstancia, el presente estudio se ocupa mayormente 
de revisar trabajos sobre las mujeres en los videoclips y, de modo residual, estudios sobre otros tipos de programacion musical que incluyen la perspectiva de genero.Los estudios sobre las mujeres en los videoclips han partido de los metodos y hallazgos anteriormente empleados para evaluar la representacion de las mujeres en los medios, especialmente en television. Por tanto, pueden trazarse lineas de continuidad que relacionan 
la representacion televisiva musical de las mujeres con el tratamiento que de ellas se viene 
haciendo en la programacion de este medio tomada en conjunto. De acuerdo con la mayoria de los trabajos revisados, cabe afirmar que en los videoclips las mujeres conocen una representacion minoritaria con respecto a los hombres; su aparicion y caracterizacion suelen incurrir en topicos y tener una elevada carga sexual; las mujeres suelen estar asociadas a roles secundarios, actitudes pasivas y dependientes de aquellas de los hombres. La violencia presente en los videoclips suele incluir el retrato de las mujeres como victimas
, explicita o implicitamente. El tratamiento visual del cuerpo de las mujeres en los videoclips suele ser fragmentario y distorsionante (tanto en el color como en el tamano y formas). Aunque de modo minoritario, las posibilidades del videoclip como herramienta del feminismo y la superacion del genero han sido objeto de estudio
PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus (2019)

Systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) of the skin are autoimmune diseases characterized by inappropriate immune responses against self-proteins; the key elements that determine disease pathogenesis and progression are largely unknown. Here, we show that mice lacking immune inhibitory receptor VISTA or programmed death-1 homolog (PD-1H KO) on a BALB/c background spontaneously develop cutaneous and systemic autoimmune diseases resembling human lupus. Cutaneous lupus lesions of PD-1H KO mice have clustering of plasmacytoid dendritic cells (pDCs) similar to human DLE. Using mass cytometry, we identified proinflammatory neutrophils as critical early immune infiltrating cells within cutaneous lupus lesions of PD-1H KO mice. We also found that PD-1H is highly expressed on immune cells in human SLE, DLE lesions, and cutaneous lesions of MRL/<i>lpr</i> mice. A PD-1H agonistic monoclonal antibody in MRL/<i>lpr</i> mice reduces cutaneous disease, autoantibodies, inflammatory cytokines, chemokines, and immune cell expansion. Furthermore, PD-1H on both T cells and myeloid cells including neutrophils and pDCs could transmit inhibitory signals, resulting in reduced activation and function, establishing PD-1H as an inhibitory receptor on T cells and myeloid cells. On the basis of these findings, we propose that PD-1H is a critical element in the pathogenesis and progression of lupus, and PD-1H activation could be effective for treatment of systemic and cutaneous lupus.
Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to HSV1 primary infection (2022)

Herpes simplex virus 1 (HSV-1) is a frequently unrecognized, yet deadly cause of acute liver failure (ALF). We, therefore, analysed three cases of fatal HSV-1-induced ALF. All patients shared clinical (extremely elevated transaminases, LDH and AST/LDH ratio < 1) and virological characteristics (ratio of viral load in plasma versus throat swabs: 60-700-fold, lack of anti-HSV-1-IgG antibodies or low IgG-avidity during primary infection), which may help to identify patients at risk. Additionally, in vitro chemosusceptibility assays revealed high efficacy of the helicase-primase inhibitors (HPI), pritelivir and drug-candidate IM-250 compared to acyclovir (ACV) using HSV-1-isolates from two patients; hence, ACV/HPI-combinations might offer new therapeutic options for HSV-induced ALF.
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells (2011)

Recent evidence has unveiled the critical role of tumor cells with stem cell activities in tumorigenicity and drug resistance, but how tumor microenvironments regulate cancer stem/initiating cells (CSCs) remains unknown. We clarified the role of tumor-associated macrophages (TAMs) and their downstream factor milk-fat globule-epidermal growth factor-VIII (MFG-E8) in the regulation of CSC activities. Bone marrow chimeric systems and adoptive cell transfers elucidated the importance of MFG-E8 from TAMs in conferring to CSCs with the ability to promote tumorigenicity and anticancer drug resistance. MFG-E8 mainly activates signal transducer and activator of transcription-3 (Stat3) and Sonic Hedgehog pathways in CSCs and further amplifies their anticancer drug resistance in cooperation with IL-6. Thus, the pharmacological targeting of key factors derived from tumor-associated inflammation provides a unique strategy to eradicate therapy-resistant tumors by manipulating CSC activities.
Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence (2006)

We report that nanoscale carbon particles (carbon dots) upon simple surface passivation are strongly photoluminescent in both solution and the solid state. The luminescence emission of the carbon dots is stable against photobleaching, and there is no blinking effect. These strongly emissive carbon dots may find applications similar to or beyond those of their widely pursued silicon counterparts.
Candidate Gene Discovery for Dog Cryptorchidism (2008)

Cryptorchidism is one of the most common developmental defects in purebred dogs. Single gene markers (called SNPs) are being used to investigate the associations in Siberian huskies between candidate genes (INSL3, LGR8, ESR1, HOXA10, MIS, CGRP and other positional candidates) and cryptorchidism. Findings of causative mutations in candidate genes will be useful in dog breeding programs to reduce the incidence of cryptorchidism.
[Reduced concentration of beta-endorphin in cerebrospinal fluid and reduced pain tolerance in patients with functional dyspepsia]. (1995)

It was investigated whether central pain mechanisms including the endogenous antinociceptive system were involved in functional dyspepsia defined as: abdominal pain without abnormal findings. Pain sensitivity was measured by an ischaemic pain test comparing 21 functional dyspepsia patients with two control groups: 1) 24 patients with organic abdominal pain, and 2) 13 healthy pain-free controls. The endogenous opioids beta-endorphin, met-enkephalin immunoreactivity, and dynorphin immunoreactivity were measured in cerebrospinal fluid (CSF) from nine patients with functional dyspepsia and pain-free controls undergoing minor surgery while under spinal analgesia. There was no significant difference between the groups in pain sensitivity, but subdivision of the functional dyspepsia group showed that individuals with pain and no symptoms of irritable bowel syndrome (IBS) were significantly more sensitive to ischaemic pain than functional dyspepsia patients with IBS. The CSF beta-endorphfin concentration was significantly decreased in the functional dyspepsia group as compared with the controls. There were no significant group differences regarding met-enkephalin immunoreactivity and dynorphin immunoreactivity. Because of post-lumbar-puncture headache, this part of the investigation was suspended after nine patients. Functional dyspepsia is probably a pain syndrome with decreased central antinociceptive activity.
An overview of directional transforms in image coding (2010)

Transform-based image coding has been the mainstream for many years, as witnessed in from the early effort in JPEG to the recent advances in HD Photo. Traditionally, a 2-D transform used in image coding is always implemented separately along the vertical and horizontal directions, respectively. However, it is usually true that many image blocks contain oriented structures (e.g., edges) and/or textures that do not follow either the vertical or horizontal direction. The traditional 2-D transform thus may not be the most appropriate one to these image blocks. This well-known fact has recently triggered several attempts towards the development of directional transforms so as to better preserve the directional information in an image block. Some of these directional transforms have been applied in image coding, demonstrating a significant coding gain. This paper presents an overview of these directional transforms as well as a discussion of some existing problems and their potential solutions.
Feasibility study of a touch-enabled active sensing approach to inspecting subsea bolted connections using piezoceramic transducers (2020)

Abstract Pipelines that stretch on for miles and miles are linked together through a multitude of bolted connections. However, each bolted connection represents a point of vulnerability that can suffer from leakage. In subsea environments, leakage can spread farther and cause even more disastrous to both economy and environment. A number of structural health monitoring methods have been proposed and explored. However, most monitoring methods require permanent installation of sensors on the structures to be monitored, which can be difficult for subsea locations. In this paper, a piezoceramic transducer enabled touch-based active sensing approach is proposed to inspect subsea bolted connections without the requirement of permanent installation of sensors on the structures. The proposed approach also aims for an easy integration with a subsea robotic system, such as a remotely operated vehicle (ROV) for bolted connection inspection. To study the feasibility of the proposed approach, a spring-loaded C-clamp shaped device that mimics two robotic fingers equipped with a pair of piezoceramic transducers is designed and fabricated. Two piezoceramic transducers are mounted on the inner surfaces of the two robotic fingers. In addition, a pair of permanent magnets are employed to ensure a temporary while constant coupling between the transducers and the both surfaces of the bolt connection, upon touching. In this way, one piezoceramic transducer generates stress waves that propagate across the connection interface, and the other PZT transducer detects the propagating stress wave. By analyzing the received stress wave signals via spectrograms and wavelet packet transformation, the status of the connection can be derived. Experimental investigations are performed on a bolted connection with different applied torques in air and in salt water (3.5% salinity), and results demonstrate effectiveness of the proposed touch-enabled active sensing for inspection of submerged bolted connection.
Retention of hydrogen in graphite (1987)

The retention of hydrogen in POCO AXF-5Q graphite has been measured at room temperature as a function of fluence and flux for H+2 ions at energies from 250 to 500 eV provided by a glow discharge. More than 2×1018 H/cm2 has been retained, and no indication of saturation has been observed to a fluence of 5×1019 H/cm2. In this experiment retention was found to increase linearly with fluence for constant flux. A flux dependence was observed; i.e., the retention rate was observed to decrease monotonically as the flux increased. A changeover experiment, deuterium to hydrogen, was conducted; the results show that significant changeover occurs (i.e., about 30% changeover for a fluence of 5×1017 D/cm2).
Joint Hand Detection and Rotation Estimation by Using CNN (2016)

Hand detection is essential for many hand related tasks, e.g. parsing hand pose, understanding gesture, which are extremely useful for robotics and human-computer interaction. However, hand detection in uncontrolled environments is challenging due to the flexibility of wrist joint and cluttered background. We propose a deep learning based approach which detects hands and calibrates in-plane rotation under supervision at the same time. To guarantee the recall, we propose a context aware proposal generation algorithm which significantly outperforms the selective search. We then design a convolutional neural network(CNN) which handles object rotation explicitly to jointly solve the object detection and rotation estimation tasks. Experiments show that our method achieves better results than state-of-the-art detection models on widely-used benchmarks such as Oxford and Egohands database. We further show that rotation estimation and classification can mutually benefit each other.
Supplementary Table S1 from Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor (2023)

&lt;p&gt;Agents, targets and target categories&lt;/p&gt;
ChemInform Abstract: UBICHINONE UND VERWANDTE SUBSTANZEN 23. MITT. SYNTH. VON CHINONEN MIT NEUEN KONDENSATIONSMITTELN (1973)

Abstract Mit Hilfe von N‐Sulfinylaminen (I) bzw. (II) können Hydrochinone (III) bzw. (X) mit isoprenoiden Alkoholen (IV), (VI) bzw. (VIII) kondensiert werden: Aus (III) und Phytol (IVa) bzw. Geraniol (IVb) werden nach Oxidation der gebildeten Hydrochinone die Chinone (Va) bzw. (Vb) erhalten; aus (III) und Nerol (VI) wird dagegen ein 2 : 3‐Gemisch des analogen Produktes (VII) mit seinem trans‐Isomeren (Vb) gebildet, und Nerolidol (VIII) gibt unter Umlagerung das Farnesylderivat (IX).
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1 (2014)

Broadly HIV-1-neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnAb development might be limited by immune tolerance controls. It has been postulated that HIV-1-infected individuals with autoimmune disease and defective immune tolerance mechanisms may produce BnAbs more readily than those without autoimmune diseases. In this study, we identified an HIV-1-infected individual with SLE who exhibited controlled viral load (<5,000 copies/ml) in the absence of controlling HLA phenotypes and developed plasma HIV-1 neutralization breadth. We collected memory B cells from this individual and isolated a BnAb, CH98, that targets the CD4 binding site (CD4bs) of HIV-1 envelope glycoprotein 120 (gp120). CH98 bound to human antigens including dsDNA, which is specifically associated with SLE. Anti-dsDNA reactivity was also present in the patient's plasma. CH98 had a mutation frequency of 25% and 15% nt somatic mutations in the heavy and light chain variable domains, respectively, a long HCDR3, and a deletion in the light chain CDR1. The occurrence of anti-dsDNA reactivity by a HIV-1 CD4bs BnAb in an individual with SLE raises the possibility that some BnAbs and SLE-associated autoantibodies arise from similar pools of B cells.