gebhart/patrepeval huggingface dataset:
Topography of Geographic Atrophy in Age-Related Macular Degeneration (2012)

Distribution and progression of existing GA patches depended both on the eccentricity from the center and total GA size. Central macular areas appeared most susceptible for the occurrence and expansion of GA. Refined analysis of distribution and directional spread is important to understand the natural history of the disease. This information will likely be helpful to design interventional GA clinical trials and associated anatomical outcome measures. (ClinicalTrials. gov number, NCT00599846.).
Isolation of dermenkephalin from amphibian skin, a high‐affinity (δ‐selective opioid heptapeptide containing a D‐amino acid residue (1989)

The predicted amino acid sequence of the biosynthetic precursor of dermorphin, a highly potent and nearly specific mu-opioid peptide from amphibian skin, contains four repeats of the dermorphin progenitor sequence and one single copy of a different heptapeptide sequence. We have developed a specific enzyme immunoassay and used synthetic peptides to detect and purify the new predicted heptapeptide (2.4 micrograms/g dry skin) from the skin of the Phyllomedusa sauvagei frog from which dermorphin was originally isolated. The identity of the novel pro-dermorphin related peptide, Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2, was established by co-chromatography with synthetic peptides on reverse-phase HPLC, immunological analysis, gas-phase sequencing, mass spectrometry and by pharmacological assays. Opioid-binding assays in vitro demonstrated that both the natural and synthetic heptapeptides displayed exceptionally high selectivity and affinity towards the delta-opioid receptors. Because of its origin and its delta-opioid (enkephalin) activity and specificity, this novel D-amino acid containing peptide is named dermenkephalin.
Retortable Food Packages Containing Water-Sensitive Oxygen Barrier (1990)

Multilayer ethylene-vinyl alcohol (EvOH) retortable food packages are steam sterilized at temperatures of 220-270°F. Water permeates through the outer package layers and into the center EvOH layer. The wet EvOH offers a reduced resistance to oxygen permeation immediately following retort. As the EvOH dries to a steady-state moisture profile, the barrier properties substantially recover, but a significant amount of oxygen can pass through the package wall during the drying stage. The long-term oxygenbarrier performance of a retortable package is a very complex function of EvOH properties and history, layer thickness, EvOH layer placement, retort time, retort temperature, and storage conditions. This study was undertaken to develop a procedure for predicting and measuring barrier performance of multilayer retortable food packages. A model that includes major variables for calculating water and oxygen permeation through the life of a retortable package is presented. Oxygen ingression tests were done on food packages to test the model. The results showed that dissolved oxygen in the package wall can make a significant contribution to oxygen gain. Package tests also suggest that there is an irreversible loss of EvOH barrier effectiveness following retort. The exact mechanism of the barrier loss is unclear; water and oxygen permeation experiments were done on thin coextruded films and provide some insight into mechanisms of transport in multilayer structures.
Corrosion of Lithium‐Ion Battery Current Collectors (1999)

The primary current‐collector materials being used in lithium‐ion cells are susceptible to environmental degradation: aluminum to pitting corrosion and copper to environmentally assisted cracking. Localized corrosion occurred on bare aluminum electrodes during simulated ambient‐temperature cycling in an excess of electrolyte. The highly oxidizing potential associated with the positive‐electrode charge condition was the primary factor. The corrosion mechanism differed from the pitting typically observed in aqueous electrolytes because each site was filled with a mixed metal/metal‐oxide product, forming surface mounds or nodules. Electrochemical impedance spectroscopy was shown to be an effective analytical tool for characterizing the corrosion behavior of aluminum under these conditions. Based on X‐ray photoelectron spectroscopy analyses, little difference existed in the composition of the surface film on aluminum and copper after immersion or cycling in electrolytes made with two different solvent formulations. Although Li and P were the predominant adsorbed surface species, the corrosion resistance of aluminum may simply be due to its native oxide. Finally, copper was shown to be susceptible to environmental cracking at or near the lithium potential when specific metallurgical conditions existed (work hardening and large grain size). © 1999 The Electrochemical Society. All rights reserved.
On the Complexity of Khovratovich et.al's Preimage Attack on Edon-R. (2009)

Based on the analysis made by van Oorschot and Wiener for the complexity of parallel memoryless collision search [5], we show that the memoryless meet-in-the-middle attack which is one part of the whole preimage attack of Khovratovich et. al. [3] on EDON-R hash function has complexity bigger than 2 n. 1
Facile oxetane formation in a rigid bicyclo[2.2.2]octane system (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile oxetane formation in a rigid bicyclo[2.2.2]octane systemScott E. DenmarkCite this: J. Org. Chem. 1981, 46, 15, 3144–3147Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/jo00328a038https://doi.org/10.1021/jo00328a038research-articleACS PublicationsRequest reuse permissionsArticle Views534Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Book Review: Cellular Replacement Therapy for Parkinson’s Disease—Where We Are Today? (2002)

The concept of replacing lost dopamine neurons in Parkinson's disease using mesencephalic brain cells from fetal cadavers has been supported by over 20 years of research in animals and over a decade of clinical studies. The ambitious goal of these studies was no less than a molecular and cellular "cure" for Parkinson's disease, other neurodegenerative diseases, and spinal cord injury. Much research has been done in rodents, and a few studies have been done in nonhuman primate models. Early uncontrolled clinical reports were enthusiastic, but the outcome of the first randomized, double blind, controlled study challenged the idea that dopamine replacement cells can cure Parkinson's disease, although there were some significant positive findings. Were the earlier animal studies and clinical reports wrong? Should we give up on the goal? Some aspects of the trial design and implantation methods may have led to lack of effects and to some side effects such as dyskinesias. But a detailed review of clinical neural transplants published to date still suggests that neural transplantation variably reverses some aspects of Parkinson's disease, although differing methods make exact comparisons difficult. While the randomized clinical studies have been in progress, new methods have shown promise for increasing transplant survival and distribution, reconstructing the circuits to provide dopamine to the appropriate targets and with normal regulation. Selected promising new strategies are reviewed that block apoptosis induced by tissue dissection, promote vascularization of grafts, reduce oxidant stress, provide key growth factors, and counteract adverse effects of increased age. New sources of replacement cells and stem cells may provide additional advantages for the future. Full recovery from parkinsonism appears not only to be possible, but a reliable cell replacement treatment may finally be near.
Solid Inclusion Transfer at a Steel-Slag Interface with Focus on Tundish Conditions (2005)

The separation of non-metallic inclusions from the steel to the slag phase in the ladle during secondary steel making operations and in the tundish and mold during casting is very crucial to the production of clean steel. In this work a theoretical study of the separation of solid inclusions, alumina and others, at the steel-slag interface applied to the actual conditions in the tundish has been carried out. The theoretical model is based on the equation of motion with the following forces acting on an inclusion as it tries to cross the interface between the metal and the slag; buoyant, added mass, rebound and drag force. A sensitivity analysis study was carried out in order to clarify which of the parameters in the model that had the largest influence on the inclusion displacement. The results showed that the interfacial tensions (σMI, σIS, σMS) and the slag viscosity (μS) have the largest influence on the predicted displacement. It was also concluded that the overall wettability should be positive and that the slag viscosity should be as low as possible to obtain the most favorable conditions for inclusion transfer at the steel-slag interface.
Low-complexity equalizers and applications (2023)

Equalizers for audio signal processing play an important role in microphones, mixing systems, mastering processors, monitor loudspeakers, and consumer devices such as smart tablets, smart phones, wireless headphones, and hearing devices. We will introduce low-complexity filter designs for equalizers based on first- and second order recursive filters. Low-complexity filter design means having the lowest number of parameters and design equations for first- and second-order difference equation realizing prescribed filter transfer functions such as low-pass, high-pass, band-pass, and all-pass filters. Based on these basic filters, we derive all-pass realizations of these standard filters and then apply them to design parametric low- and high-frequency shelving filters and peak filters. These last two versions of weighting filters are based on three parameters, namely, the cut-off or center frequency, the bandwidth or Q factor, and the gain in dB for a low-, mid-, or high frequency band and are, therefore, named parametric equalizers. These parametric equalizers' PEQs occur in a channel-strip of a mixing console and are an integral part of the mixing process. We will describe several further applications of PEQs for amp and loudspeaker modeling, headphone equalization and head-related transfer function modeling, and audio coding. All applications allow a low-complexity filter design, parameter update, and efficient recursive filter implementations with much lower complexity compared to non-recursive filters.
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. (1995)

Human mononuclear phagocytes can modulate the turnover of extracellular matrix by producing metalloproteinases such as 92-kD gelatinase and interstitial collagenase as well as the tissue inhibitor of metalloproteinases (TIMP). We have previously reported that IL-4 and IFN gamma released by lymphocytes suppress metalloproteinase biosynthesis in macrophages without affecting TIMP production (Lacraz, S., L. Nicod, B. C. de Rochementeix, C. Baumberger, J. Dayer, and H. Welgus. 1992. J. Clin. Invest. 90:382-388.; Shapiro, S. D., E. J. Campbell, D. K. Kobayashi, and H. G. Welgus 1990. J. Clin. Invest. 86:1204-1210). Like IL-4, IL-10 is secreted by Th2 lymphocytes and is inhibitory to several macrophage functions. In the present study, IL-10 was tested and compared to IL-2, IL-4, IL-6, and IFN gamma for its capacity to modulate synthesis of 92-kD gelatinase, interstitial collagenase and TIMP in human macrophages and monocytes. We found that IL-10, just like IL-4, inhibited the production of 92-kD gelatinase and blocked LPS-, as well as killed Staphylococcus aureus-induced, interstitial collagenase production. The principal finding of this study, however, was that IL-10, in distinction to IL-4, produced a dose-dependent stimulation in the biosynthesis of TIMP-1. TIMP-2 production was not affected. IL-10 regulated the expression of 92-kD gelatinase and TIMP-1 at the pretranslational level. Furthermore, IL-10 regulation was cell type-specific, as it had no effect on the production of metalloproteinases or TIMP by human fibroblasts. In summary, IL-10 has a potent and unique effect upon tissue macrophages and blood monocytes by enhancing TIMP-1 production while decreasing metalloproteinase biosynthesis.
Effects of temperature variations in high-sensitivity Sagnac gyroscope (2021)

Abstract GINGERINO is one of the most sensitive Sagnac laser-gyroscopes based on an heterolithic mechanical structure. It is a prototype for GINGER, the laser gyroscopes array proposed to reconstruct the Earth rotation vector and in this way to measure General Relativity effects. Many factors affect the final sensitivity of laser gyroscopes, in particular, when they are used in long-term measurements, slow varying environmental parameters come into play. To understand the role of different terms allows to design more effective mechanical as well as optical layouts, while a proper model of the dynamics affecting long-term (low frequency) signals would increase the effectiveness of the data analysis for improving the overall sensitivity. In this contribution, we focus our concerns on the effects of room temperature and pressure aiming at further improving mechanical design and long-term stability of the apparatus. Our data are compatible with a local orientation changes of the Gran Sasso site below $$\mu $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>μ</mml:mi> </mml:math> rad as predicted by geodetic models. This value is consistent with the requirements for GINGER and the installation of an high-sensitivity Sagnac gyroscope oriented at the maximum signal, i.e. along the Earth rotation axes.
A Novel Solid-Phase Approach to 2,4-Diaminothiazoles (2000)

A novel solid-phase synthesis of a 2,4-diaminothiazole library starting from a polymer-bound thiouronium salt is described. The synthetic strategy involves formation of polymer-bound thioureido-thiourea intermediates [5] which by treatment with alpha-bromo-ketones [6] undergoes S-alkylation, followed by a base-catalyzed intramolecular-ring closure/cleavage to give 2,4-diaminothiazoles [8]. This strategy tolerates a wide range of functionality and protecting groups. The novel feature of our method is a polymer-supported auto-scavenging strategy (PSAS), which provides a clean, high-yielding, and traceless synthesis to 2,4-diaminothiazoles.
Application of Si-N Insulating Layer to CPP-GMR Device (2009)

Tb-Fe-Co, an RE-TM alloy, is a promising material for perpendicular magnetic CPP-GMR devices. Because the spontaneous magnetization of RE-TM alloy can be controlled by its composition, the magnetic field generated from the pinned layer can be reduced by using a Tb-Fe-Co alloy film for the pinned layer. However, Tb-Fe-Co oxidizes easily. In this study, we applied a Si-N insulating layer to a CPP-GMR device in place of a SiO2 protective layer and successfully improved the magnetic characteristics of the Tb-Fe-Co pinned layer.
Solid-hexatic-liquid phases in two-dimensional charge-density waves (1992)

The structural order of the two-dimensional (2D) charge-density-wave (CDW) phase in ${\mathrm{Nb}}_{\mathit{x}}$${\mathrm{Ta}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{S}}_{2}$ materials has been determined as a function of impurity concentration from the quantitative analysis of scanning tunneling microscopy images. We show that the CDW phase evolves through crystalline, hexatic glass, and liquidlike states as the impurity concentration in the lattice increases to x=0.10. These results address systematically the structural manifestations of quenched disorder in 2D systems.
Quantification of preferential orientation in conjugated polymers using X‐ray diffraction (2003)

Abstract The varying degree of preferential orientation observed in films of poly(alkylthiophene)s obtained by solution casting from different solvents has been studied quantitatively with X‐ray diffraction. The (uniaxial) orientational distribution function is obtained after some important instrumental corrections that are described in detail. Orientational distribution functions of an exponential type are found to give an adequate description with only a few fitted parameters, unlike Legendre series fits, which require longer series. An attempt has been made to relate the anisotropy to the chemical and physical properties of the solvents used. The anisotropy seems to be higher for samples cast from solvents with low boiling points and, correspondingly, high vapor pressures. Also, the average crystallite size is solvent‐dependent. The characteristic dimension of the crystallites in the a ‐axis direction appears to be longest for crystallites with the a axis parallel to the film normal. Along the b axis, that is, the π‐stacking direction, the crystallite dimension is shorter than along the a axis. Also, the amorphous regions of the films exhibit anisotropy. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 2375–2393, 2003
A note on minimizing time assurance tests for repairable systems (2021)

Abstract We consider assurance testing for repairable systems when supplementary information is available in addition to the data collected in the assurance test. The supplementary information is incorporated using a Bayesian inferential framework. Here we consider assurance testing for a homogeneous Poisson process. In this note we consider an alternative criterion that minimizes the test time while ensuring that the requirements on the producer's and consumer's risks are met. We illustrate the use of this alternative criterion with an example.
An Open‐Label Study of CP‐101,606 in Subjects with a Severe Traumatic Head Injury or Spontaneous Intracerebral Hemorrhage (1999)

CP-101,606 is a postsynaptic antagonist of N-methyl-D-aspartate (NMDA) receptors bearing the NR2B subunit. When administered intravenously (i.v.), it decreases the effects of traumatic brain injury (TBI) and focal ischemia in animal models. Therapeutic plasma concentrations (200 ng/ml) in animals, have been well tolerated in healthy human volunteers. The purpose of the present dose escalation study was to assess the safety, tolerability, and pharmacokinetics of CP-101,606 in subjects who had suffered either an acute severe TBI (Glasgow Coma Scale 3-8) or spontaneous intracerebral hemorrhage. Thirty patients, 20 with a TBI and 10 with a stroke, were enrolled in the trial and began receiving an i.v. infusion of CP-101,606 for 2 hours, 24 hours, or 72 hours within 12 hours of brain injury. For the first two hours, the drug was given a rate of 0.75 mg/kg/hr and then stopped (n = 17) or continued for 22 (n = 2) or 70 hours (n = 11) at 0.37 mg/kg/hr. Plasma and cerebrospinal fluid (CSF) were collected at serial times during and after treatment. There were no consistent changes in blood pressure or pulse nor any clinically significant hematological or electrocardiogram (ECG) abnormalities attributable to CP-101,606. No adverse events or behavioral changes were considered to be related to the drug. Plasma concentrations of CP-101,606 over 200 ng/ml were rapidly achieved in the blood and CSF within two hours and were sustained there as long as the drug was infused. CSF concentrations were slightly higher than that in plasma by the end of infusion suggesting good penetration of CP-101,606 into the CSF. Outcome in the severe TBI patients, as measured by the Glasgow Outcome Score at six months, suggested that a two-hour infusion yielded a range of scores similar to contemporary patients with a severe TBI treated at our hospital while the outcomes of the patients treated with either a 24- or 72-hour infusion were better on average. Thus, these results indicate that CP-101,606 infused for up to 72 hours is well tolerated, penetrates the CSF and brain, and may improve outcome in the brain-injured patient.
Illumination normalization with time-dependent intrinsic images for video surveillance (2004)

Variation in illumination conditions caused by weather, time of day, etc., makes the task difficult when building video surveillance systems of real world scenes. Especially, cast shadows produce troublesome effects, typically for object tracking from a fixed viewpoint, since it yields appearance variations of objects depending on whether they are inside or outside the shadow. In this paper, we handle such appearance variations by removing shadows in the image sequence. This can be considered as a preprocessing stage which leads to robust video surveillance. To achieve this, we propose a framework based on the idea of intrinsic images. Unlike previous methods of deriving intrinsic images, we derive time-varying reflectance images and corresponding illumination images from a sequence of images instead of assuming a single reflectance image. Using obtained illumination images, we normalize the input image sequence in terms of incident lighting distribution to eliminate shadowing effects. We also propose an illumination normalization scheme which can potentially run in real time, utilizing the illumination eigenspace, which captures the illumination variation due to weather, time of day, etc., and a shadow interpolation method based on shadow hulls. This paper describes the theory of the framework with simulation results and shows its effectiveness with object tracking results on real scene data sets.
Increased urinary nitrosamine excretion in patients with urinary diversions (1989)

Tumor development at the site of ureterointestinal anastomosis is a recognized complication in patients with continent urinary diversions. Aerobic cultures of rectal urine samples from 30 patients with urinary diversions (26 ureterosigmoidostomies, two colon conduits, one ileal conduit and a Gersuny bladder) showed a complex bacterial flora containing nitrate-reducing organisms (Escherichia coli, Proteus and Klebsiella spp.). In comparison to normal bladder urine samples from control volunteers (n = 20), rectal urine samples from ureterosigmoidostomy patients (n = 26) showed a significant decrease (P less than 0.0001) in urinary nitrate (0.93 +/- 0.39 versus 0.27 +/- 0.23 mmol/l), a significant increase (P less than 0.0001) in urinary nitrite (not detected versus 29.24 +/- 39.93 mumol/l) as well as a significant increase (P = 0.013) in urinary N-nitroso compound excretion (57.33 +/- 33.87 versus 93.96 +/- 65.76 nmol/l). Significant increases were also found for the urinary excretion of individual volatile and non-volatile N-nitroso compounds, clearly demonstrating a bacterially mediated in vivo formation of N-nitroso compounds in the 'colon' bladders of patients with urointestinal diversions that may be an important etiological risk factor for colon carcinogenesis in this patient group.