gebhart/patrepeval huggingface dataset:
Role for MKL1 in megakaryocytic maturation (2009)

Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during murine megakaryocytic differentiation and that enforced overexpression of MKL1 enhances megakaryocytic differentiation. When the human erythroleukemia (HEL) cell line is induced to differentiate with 12-O-tetradecanoylphorbol 13-acetate, overexpression of MKL1 results in an increased number of megakaryocytes with a concurrent increase in ploidy. MKL1 overexpression also promotes megakaryocytic differentiation of primary human CD34(+) cells cultured in the presence of thrombopoietin. The effect of MKL1 is abrogated when SRF is knocked down, suggesting that MKL1 acts through SRF. Consistent with these findings in human cells, knockout of Mkl1 in mice leads to reduced platelet counts in peripheral blood, and reduced ploidy in bone marrow megakaryocytes. In conclusion, MKL1 promotes physiologic maturation of human and murine megakaryocytes.
Measurements of the operating characteristics of a large-area avalanche photodiode (1992)

We have measured the dark current (<i>I<sub>d</sub></i>) and noise equivalent power (NEP) of four large-area (~0.8 cm<sup>2</sup>) avalanche photodiodes (APD) to determine their sensitivity limit for detecting weak optical communication signals. We found that from room temperature down to about -10°C the <i>I<sub>d</sub></i> decreased by one-half for every 8-deg drop in temperature and the NEP decreased by one-half for every 16-deg drop in temperature. Below this temperature, the NEP leveled off at somewhat less than 5 pW in a 100-kHz bandwidth. We describe the measurement technique, present an analysis of the data, and discuss the statistical properties of these APDs according to the model developed by McIntyre et al.
Recovery of Phosphorus and other Nutrients during Pyrolysis of Chicken Manure (2018)

Feedstock recycling of secondary raw materials is the backbone of the Circular Economy (CE). The efficient recovery of resources, energy, along with achieving minimal environmental impact is mandatory for the successful realization of CE. Chicken manure is an interesting waste stream due to its content of nutrients, in particular of phosphorus, which makes it a suitable feedstock for fertilizer applications. However, the contamination caused by antibiotics, organic pollutants, and sanitary aspects demand the manures treatment before further recycling. Thermochemical treatment based on intermediate pyrolysis targets decentral application to produce carbonized solids for fertilizer application. This work evaluated pyrolysis char from the pyrolysis of chicken manure in comparison to the original feedstock using state-of-the-art thermal treatment, i.e., combustion in grate furnaces. The samples were evaluated in terms of chemical and mineralogical composition by applying several analytical techniques. Bio-availability of the main nutrients (NPK) was assessed by adopting standard methods. Additionally, the effect on toxicity was discussed by means of heavy metals analysis, as well as of pot tests. Results showed, that pyrolysis had a far more positive effect on nutrient availability compared to combustion, and it provided a suitable method for the thermal treatment of contaminated feedstocks.
Flame Attachment and Flame Spread (2018)

This chapter argues that formulations based on coupling functions are particularly useful for reacting boundary layers. It addresses a general theoretical framework, within which a wide variety of reacting boundary-layer problems. The chapter illustrates the application of the theory, the burning of a flat plate of fuel in an oxidizing stream and explores the mechanisms of flame stabilization and processes of flame spread and shows that the onset of combustion can cause the boundary-layer approximation to fail. Combustion processes in which flames interact with solid or liquid surfaces are relatively complicated, yet are of importance under many conditions of interest. The distance along the plate from the point at which heating is initiated to the point at which heat begins to flow back into the plate is a measure of the length of a hot plate required to stabilize a flame. A number of different specific criteria for flame attachment in the mixing zone may be identified.
Experimental investigations on the grouping behaviour in a mono-disperse droplet stream (2021)

Clustering of droplets in a spray, referred to as 'droplet grouping', is an important phenomenon which affects droplet vaporization and combustion processes. The factors which govern droplet grouping mechanics are not yet fully understood. In this experimental study we consider a single stream of monodisperse droplets to investigate droplet grouping. A circular cylindrical jet of isopropanol is injected into ambient air through a circular hole under a controlled upstream pressure. The jet is broken into droplets by excitation using a piezo element. A double frequency excitation generates a stream of droplet groups each consisting of two droplets. The droplets are injected into a quiescent ambient air at velocities much greater than their terminal velocity of free fall. From high-resolution images of the droplet stream, the evolution of the intra-and inter-group distances is measured. It is observed that, for the experimental conditions explored here, the droplets within a group approach each other, collide, coalesce, and exhibit droplet shape oscillations. The characteristics of the droplet grouping process are reported.
Mycobacterium tuberculosis Up-Regulates Matrix Metalloproteinase-1 Secretion from Human Airway Epithelial Cells via a p38 MAPK Switch (2005)

Pulmonary cavitation is vital to the persistence and spread of Mycobacterium tuberculosis (MTb), but mechanisms underlying this lung destruction are poorly understood. Fibrillar type I collagen provides the lung's tensile strength, and only matrix metalloproteinases (MMPs) can degrade it at neutral pH. We investigated MTb-infected lung tissue and found that airway epithelial cells adjacent to tuberculosis (Tb) granulomas expressed a high level of MMP-1 (interstitial collagenase). Conditioned media from MTb-infected monocytes (CoMTb) up-regulated epithelial cell MMP-1 promoter activity, gene expression, and secretion, whereas direct MTb infection did not. CoMTb concurrently suppressed tissue inhibitor of metalloprotease-1 (TIMP-1) secretion, further promoting matrix degradation, and in Tb patients very low TIMP-1 expression was detected. MMP-1 up-regulation required synergy between TNF-alpha and G protein-coupled receptor signaling pathways. CoMTb stimulated p38 MAPK phosphorylation, and this is the point of TNF-alpha synergy with G protein-coupled receptor activation. Furthermore, p38 phosphorylation was the switch up-regulating MMP-1 activity and decreasing TIMP-1 secretion. Activated p38 localized to MMP-1-secreting airway epithelial cells in Tb patients. These data reveal a monocyte-epithelial cell network whereby MTb may drive tissue destruction, and they demonstrate that p38 phosphorylation is a key regulatory point in the generation of a matrix-degrading phenotype.
Energy-aware routing in sensor networks: A large systems approach (2006)

http://citi.insa-lyon.fr/wons2006/index.html
A practitioner's guide to cancer-related alopecia. (1998)

Alopecia due to the side effects of the treatment of cancer is one of the most common and emotionally troublesome effects of cancer therapy. Preventive measures, primarily scalp hypothermia, can be effective in some cases, but the worry of subsequent scalp metastasis remains. Investigative studies in animals are hindered by a poor animal alopecia model. Several promising agents require translation into clinical practice. Until then, disguising the alopecia with wigs, hats, or turbans remains the mainstay of treatment.
Region-based Partial-Duplicate Image Retrieval (2012)

The spring up of large numbers of partial-duplicate images on the internet brings a new challenge to the image retrieval systems. Rather than taking the image as a whole, researchers bundle the local visual words by MSER detector into groups and add simple relative ordering geometric constraint to the bundles. Experiments show that bundled features become much more discriminative than single feature. However, in order to achieve more discriminative power, the bundle should be carefully extracted with elaborate contour, which can separate different objects and exclude irrelative visual words. In this paper, we propose a novel partial-duplicate image retrieval scheme based on regions extract by saliency analysis. In addition, to increase the discriminative power and robustness for coping with various transformations such as flip and rotation, the visual words detected in the region are further restrained by an affine invariant constraint. The affine invariant constraint employs the area ratio invariance property of affine transformation to build the affine invariant matrix for bundled visual words. Experimental results on the internet partial-duplicate image database verify the effectiveness of our approach.
Reconstitution de dose par calcul Monte Carlo en cas d’accident radiologique : application à l’accident du Chili de décembre 2005 (2007)

À la suite d’un accident radiologique dû à une source de gammagraphie survenu au Chili en décembre 2005 et impliquant une victime, l’IRSN a été sollicité pour réaliser la reconstitution dosimétrique par calcul Monte Carlo. Des outils, développés au laboratoire, associant des fantômes anthropomorphes mathématiques et voxélisés au code de calcul Monte Carlo mcnpx ont été mis en œuvre afin de déterminer la distribution de dose au niveau de la fesse gauche de la victime et la dose aux organes critiques. La cartographie dosimétrique réalisée au niveau de la fesse gauche montre que la dose à la surface est importante (1900 Gy) et chute rapidement pour atteindre 20 Gy à 5 cm de profondeur. Les calculs réalisés avec un fantôme mathématique indiquent que les doses moyennes aux organes critiques sont faibles et permettent d’identifier de possibles sites de prélèvement de moelle osseuse. S’appuyant sur la cartographie dosimétrique, une exérèse de 5 cm de profondeur et de 10 cm de diamètre a été pratiquée au niveau de la fesse gauche de la victime.
Nanostructural Analyses of Intra- and Intergranular Precipitates in High-temperature Heat-treated Nitrogen-added Austenitic Stainless Steel (2018)

More than one thousand intragranular and intergranular precipitates of nitrogen-added austenitic stainless steel, SUSXM15J1, were characterized by FIB-SEM serial-sectioning tomography, by conventional transmission electron microscopy (TEM) and by scanning transmission electron microscopy (STEM). All of intragranular precipitates were found nitrided to form dichromium nitride, Cr 2 N, two types of intergranular precipitates were found Cr 2 N and Cr 3 Ni 2 Si(N), and some of them were grown and jointed due to the additional heat treatment during the tensile test at 1 173 K, which probably contributed to its high-temperature strength.
Changing the Cell Source in Cell Therapy? (2004)

One dream of scientists is to be able to rebuild, in vitro, “spare parts” to replace injured or diseased tissues — a notion that was once relegated to the realm of science fiction. The concept that stem cells that are ostensibly site-specific can give rise to (and maintain) mature tissues has made adult stem cells the focus of intense research designed to explore their promise for the treatment of a variety of human diseases.Adult stem cells are defined as clonogenic, self-renewing progenitor cells that can generate one or more specialized types of cells. However, major obstacles in this field . . .
86 Skeletal response to whole body vibration and dietary calcium and phosphorus in growing pigs (2019)

Abstract Whole body vibration (WBV) is reported to elicit increased bone mass and strength. This experiment was designed to determine the effects of whole body vibration (WBV) and dietary calcium (Ca) and phosphorus (P) on bone microarchitecture and turnover. A total of 26 growing pigs were utilized in a 60-d experiment. Pigs were randomly assigned within group to a 2 × 2 factorial with Ca and P concentration (low and adequate) and WBV. Low Ca, P diets were 0.9 g/kg less than recommended levels of Ca and available P. Pigs receiving WBV were vibrated 30 min/d, 3 d/wk at a magnitude of 1-2mm and frequency of 50 Hz. On d 0, 30, and 60, digital radiographs were taken to determine bone mineral content by radiographic bone aluminum equivalency (RBAE) and blood was collected for bone formation biomarker (osteocalcin, OC) and bone resorption biomarker (carboxy-terminal collagen crosslinks, CTX-I). At d 60, pigs were harvested and the left third metacarpal bone was excised for analysis by micro computed tomography (microCT) to measure trabecular microarchitecture and cortical bone geometry. Maximum RBAE values for the medial or lateral cortices were not affected (P &gt; 0.05) by WBV. Pigs fed adequate Ca and P tended (P = 0.10) to have increased RBAE max values for the medial and lateral cortices. Vibrated pigs had decreased CTX-1 concentrations (P = 0.044). Pigs fed decreased Ca and P had increased (P &lt; 0.05) concentrations of OC. Vibrated pigs had lower trabecular number (P = 0.002) and increased trabecular separation (P = 0.003), whereas cortical bone parameters were not changed by WBV or diet (P &gt; 0.05). Whole body vibration in this study did not elicit an osteogenic response; however, early indications of bone turnover were observed.
^(82)Sr/^(82)Rb 발생기의 제조 및 정상인 심근의 양전자 단층촬영상 (1994)

A Sr/Rb generator was prepared by loading Sr to preconditioned tin dioxide column. The generator was eluted by normal saline with flow rate up to 8ml/min, and the eluted radioactivity was monitored by dose calibrator. Radioactivity began to come out at 5ml and reached to peak around 9ml. The total eluted radioactivity increased linearly with flow rate, and the maximum obtained radioactivity was 35mCi at 8ml/min. The Rb preparation was proven to be free from both strontium radioactivity and pyrogen. The Rb was injected to normal female valunteer and positron emission tomographic image of heart was obtained successfully.
No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise (2001)

To investigate the influence of heat stress on the regulation of skeletal muscle carbohydrate metabolism, six active, but not specifically trained, men performed 5 min of cycling at a power output eliciting 70% maximal O2 uptake in either 20 degrees C (Con) or 40 degrees C (Heat) after 20 min of passive exposure to either environmental condition. Although muscle temperature (T(mu)) was similar at rest when comparing trials, 20 min of passive exposure and 5 min of exercise increased (P < 0.05) T(mu) in Heat compared with Con (37.5 +/- 0.1 vs. 36.9 +/- 0.1 degrees C at 5 min for Heat and Con, respectively). Rectal temperature and plasma epinephrine were not different at rest, preexercise, or 5 min of exercise between trials. Although intramuscular glycogen phosphorylase and pyruvate dehydrogenase activity increased (P < 0.05) at the onset of exercise, there were no differences in the activities of these regulatory enzymes when comparing Heat with Con. Accordingly, glycogen use in the first 5 min of exercise was not different when comparing Heat with Con. Similarly, no differences in intramuscular concentrations of glucose 6-phosphate, lactate, pyruvate, acetyl-CoA, creatine, phosphocreatine, or ATP were observed at any time point when comparing Heat with Con. These results demonstrate that, whereas mild heat stress results in a small difference in contracting T(mu), it does not alter the activities of the key regulatory enzymes for carbohydrate metabolism or glycogen use at the onset of exercise, when plasma epinephrine levels are unaltered.
Air temperature and mean radiant temperature data, collected and simulated across a radiantly-heated high-bay laboratory (2020)

To better understand the extent of how the air temperature and mean radiant temperature may vary both spatially and temporally in a radiantly heated space, we conducted a seven-day experiment in the architectural laboratory at School of Architecture, Princeton University. The primary intent of this paper was to decouple the measurement of the air temperature and mean radiant temperature. We collected a large dataset that shows temporal and spatial variations. To do so, we used non-contact infrared thermometer to measure the surface temperatures of the surrounding surfaces inside the laboratory. The geometry of the laboratory is simplified into a box, the corresponding view factor from every point within the box can be calculated towards each internal surface. These view factors are then combined with the measured surface temperatures to produce mean radiant temperatures. This spatial mean radiant temperature distribution was then compared with the air temperature distribution measured by the air temperature sensors suspended from the ceiling of the laboratory. We believe making these data available will help future researchers working on similar problems to develop protocols than the state-of-the-art measurement techniques observed among different thermal comfort or radiant heat transfer research.
Belastung von Betroffenen mit MRKH-Syndrom: Effekt einer Intervention zur Unterstützung bei Neovagina-Anlage (2022)

The diagnosis of Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), a rare variant of female sexual development, is usually made during puberty. The uncertainty in self-image and the impos-sibility of becoming pregnant often lead to considerable stress. Although psychosomatic support is consistently recommended in the literature, there have been only a few studies on the psychological aspects of MRKHS. The aim of the present study is to investigate the quality of life or distress of women with MRKHS undergoing neovaginal surgery and, on the other hand, to evaluate effects of the intervention for support during treatment. Methods In an explorative quasi-experimental pre-post study at a national centre for neovaginal surgery, all patients were offered a psychosomatic intervention (intervention group IG, n=23) and their sexual function (FSFI), psychological distress (PHQ-D) and health-related quality of life (SF-12) were assessed before surgery (t0) and six months after (t1). These were compared with data from a sample collected before and after the intervention period (comparison group VG, n=30). Results While the physical quality of life (SF-12) of both groups was unremarkable at both time points, there was a significant impairment in the psychological quality of life. Both groups (IG, VG) improved from t0 to t1 in their sexual function (FSFI) and showed lower depression scores (PHQ-D). The specific intervention developed was well accepted by those affected and rated as helpful. However, this subjectively perceived effectiveness of the intervention was not reflected by improvement on the quality of life scale (SF-12) and depression scale (PHQ-D). Conclusion Those affected show a clear, clinically relevant distress (SF-12), but this is not reflected in the form of psychological comorbidity (PHQ-D). This apparent discrepancy points to psychologically stable women with acute distress due to the diagnosis of variant sex de-evolution. For them, a low-threshold support service with a supportive character seems to be necessary and helpful during the surgical treatment. The reconstructive therapy for the creation of a neovagina seems to have a positive influence on the psychological quality of life. The fact that pregnancy is still not possible due to the missing uterus could be a reason for not reaching the quality of life of the average population.
Realization of Remote Distributed Control System Based on MO-DEM (2007)

MODEM and DF1 communication protocal were used to realize interlinkage of DH-485 local area network, which constituted the remote distributed control system to control 11 kilometer long multi-belt conveyor, and the structure and control scheme were provided.
Resource Scheduling in Wireless Networks Using Directional Antennas (2010)

Due to a continued increase in the speed and capacities of computing devices, combined with our society's growing need for mobile communication capabilities, multihop wireless networks (MWNs), such as wireless mesh networks (WMNs), have gained a lot of interest from the research community. Quality of service (QoS) provisioning in these networks is an essential component that is needed to support multimedia and real-time applications. On the other hand, directional antenna technology provides the capability for considerable increases in spatial reuse, which is essential in the wireless medium. In this paper, a bandwidth reservation protocol for QoS routing in TDMA-based MWNs using directional antennas is presented. The routing algorithm allows a source node to reserve a path to a particular destination with the needed bandwidth, which is represented by the number of slots in the data phase of the TDMA frame. Further optimizations to improve the efficiency and resource utilization of the network are also provided.
Normal human polyspecific immunoglobulin G (intravenous immunoglobulin) modulates endothelial cell function in vitro (1995)

We have analysed the in-vitro effect of pooled normal polyspecific immunoglobulin G (IVIg) and F(ab')2 fragments of IVIg on the secretion of prostacyclin (PGI2), thromboxane A2 (TxA2), and endothelin from cultured human umbilical vein endothelial cells. The stable metabolites, 6-keto-PGF1 alpha and TxB2, as well as endothelin, were measured by radioimmunoassay after extraction from the culture supernatants. IVIg inhibited TxB2 and endothelin secretion in a dose-dependent manner, but not that of 6-keto-PGF1 alpha. Therefore the ratio of 6-keto-PGF1 alpha/TxB2 increased (+600%). The effect of F(ab')2 fragments prepared from IVIg was similar to that observed with IVIg, indicating that the effect of IVIg was mediated by the variable region of immunoglobulin. The results suggest that part of the effects of IVIg in inflammatory vasculitis may be due to a modification of the PGI2/TxA2 ratio and inhibition of endothelin secretion, and that natural IgG antibodies may participate in the homeostatic process of endothelium under physiological conditions.