gebhart/patrepeval huggingface dataset:
In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters (2013)

Fluorescence imaging in vivo allows non-invasive tumor diagnostic thus permitting a direct monitoring of cancer therapies progresses. It is established herein that fluorescent gold nanoclusters are spontaneously biosynthesized by cancerous cell (i.e., HepG2, human hepatocarcinoma cell line; K562, leukemia cell line) incubated with micromolar chloroauric acid solutions, a biocompatible molecular Au(III) species. Gold nanoparticles form by Au(III) reduction inside cells cytoplasms and ultimately concentrate around their nucleoli, thus affording precise cell imaging. Importantly, this does not occur in non-cancerous cells, as evidenced with human embryo liver cells (L02) used as controls. This dichotomy is exploited for a new strategy for in vivo self-bio-imaging of tumors. Subcutaneous injections of millimolar chloroauric acid solution near xenograft tumors of the nude mouse model of hepatocellular carcinoma or chronic myeloid leukemia led to efficient biosynthesis of fluorescent gold nanoclusters without significant dissemination to the surrounding normal tissues, hence allowing specific fluorescent self-bio-marking of the tumors.
The Metabolome-Wide Association Study: A New Look at Human Disease Risk Factors (2008)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Metabolome-Wide Association Study: A New Look at Human Disease Risk FactorsJeremy K. Nicholson, Elaine Holmes, and Paul ElliottView Author Information Department of Biomolecular Medicine, Imperial College London Department of Epidemiology and Public Health, Imperial College LondonCite this: J. Proteome Res. 2008, 7, 9, 3637–3638Publication Date (Web):August 16, 2008Publication History Published online16 August 2008Published inissue 5 September 2008https://pubs.acs.org/doi/10.1021/pr8005099https://doi.org/10.1021/pr8005099editorialACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2935Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (112 KB) Get e-AlertscloseSUBJECTS:Anatomy,Bacteria,Biomarkers,Genetics,Genomics Get e-Alerts
Twitter-Based Recommender System to Address Cold-Start: A Genetic Algorithm Based Trust Modelling and Probabilistic Sentiment Analysis (2015)

This paper investigates the design and evaluation of a personalized Recommender System (RS) using implicit social trust from Online Social Networks (OSNs), particularly to solve new users' recommendation problems. The proposed system builds implicit trust based on the interrelation between an active user and his/her friends in the popular social microblogger Twitter, by considering aspects such as retweet actions and followers/followings lists. The measured trust values are used to vote for friends' opinions held in the posted tweets about a certain product such as movies. The higher trust parameters to a friend the more his/her opinions anticipate in recommendations encounter. Firstly, Friends' opinions are obtained by a probabilistic sentiment analysis technique to extract the opinions in form of multi-point scale of ratings from short tweets. Secondly, trust relation aspects are extracted from user's friends accounts. Further, a genetic algorithm is used to optimize social trust parameters. Thirdly, this paper considers the Support Vector Regression algorithm (SVR) to predict ratings for the active user. Our experimental results show that the proposed approach outperforms several related works in terms of accuracy using real world data from Twitter. These results can have a promising effect when solving new users, so called cold-start problem, to the systems by integrating users' OSNs.
ChemInform Abstract: Stereoselective Synthesis of Conjugated Bisallenols as Precursors of Novel Bis(2,5‐dihydrofuran) Derivatives. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Seamless Fusion of Secure Software and Trusted USB Token for Protecting Enterprise &#x0026; Government Data (2011)

Smart cards have been used in a wide variety of vertical markets delivering security services related to physical access control, user authentication and high value data transactions. However, their adoption in plug-n-play removable data storage markets is generally hindered by their dependence on external smart card reader hardware, their proprietary communication protocol that requires installation of card specific middle-ware, and their limited storage capacity. This is particularly true when using smart cards to store encrypted bulk data that meets the stringent security requirements of government agencies and enterprise IT departments. This paper outlines some of these requirements and presents a unique hardware and software architecture to address them. It combines the copious storage capacity of USB mass storage tokens with the proven security features of smart cards without requiring any smart card specific infrastructure. The resulting USB composite token can be used as a secure flexible platform to build advanced data protection applications.
CT Demonstration of the 1996 AJCC-UICC Regional Lymph Node Classification for Lung Cancer Staging (1999)

The new international lymph node classification adopted by the American Joint Committee on Cancer (AJCC) and the Union Internationale Contre le Cancer (UICC) is described and illustrated with computed tomography (CT). Anatomic landmarks for 14 hilar, intrapulmonary, and mediastinal lymph node stations are designated. Main differences between the new international classification and the American Thoracic Society (ATS) one are emphasized. In particular, mediastinal pleural reflection is now used to differentiate N2 from N1 nodes. The ATS 10L (left peribronchial nodes) and 10R (right tracheobronchial nodes) stations are now replaced by the AJCC-UICC station 10 (hilar nodes) and the AJCC-UICC station 4 (lower paratracheal, including azygos, nodes), respectively. This very important difference from the ATS classification helps classify the 4 lower paratracheal nodes as N2 nodes, even though the pleural reflection is not seen with CT. The 5 AJCC-UICC nodes are renamed subaortic nodes instead of aortopulmonary ATS nodes. Paraortic nodes, which previously were classified as 5 ATS nodes, are now included with the 6 AJCC-UICC nodes (now renamed paraaortic nodes instead of anterior mediastinal ATS nodes). This change helps accurate labeling because the border between 5 and 6 ATS nodes was not always clear on CT scans. Radiologists should be familiar with this new classification to be able to more accurately compare the lung cancer staging done in different institutions around the world.
Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease (2010)

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in most western countries. Current NAFLD diagnosis methods (e.g., liver biopsy analysis or imaging techniques) are poorly suited as tests for such a prevalent condition, from both a clinical and financial point of view. The present work aims to demonstrate the potential utility of serum metabolic profiling in defining phenotypic biomarkers that could be useful in NAFLD management. A parallel animal model/human NAFLD exploratory metabolomics approach was employed, using ultra performance liquid chromatography-mass spectrometry (UPLC-MS) to analyze 42 serum samples collected from nondiabetic, morbidly obese, biopsy-proven NAFLD patients, and 17 animals belonging to the glycine N-methyltransferase knockout (GNMT-KO) NAFLD mouse model. Multivariate statistical analysis of the data revealed a series of common biomarkers that were significantly altered in the NAFLD (GNMT-KO) subjects in comparison to their normal liver counterparts (WT). Many of the compounds observed could be associated with biochemical perturbations associated with liver dysfunction (e.g., reduced Creatine) and inflammation (e.g., eicosanoid signaling). This differential metabolic phenotyping approach may have a future role as a supplement for clinical decision making in NAFLD and in the adaption to more individualized treatment protocols.
ROCK as a Therapeutic Target of Diabetic Retinopathy (2010)

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.
Pharmacological Rescue of Mutant p53 Conformation and Function (1999)

Compounds that stabilize the DNA binding domain of p53 in the active conformation were identified. These small synthetic molecules not only promoted the stability of wild-type p53 but also allowed mutant p53 to maintain an active conformation. A prototype compound caused the accumulation of conformationally active p53 in cells with mutant p53, enabling it to activate transcription and to slow tumor growth in mice. With further work aimed at improving potency, this class of compounds may be developed into anticancer drugs of broad utility.
A distributed control architecture of high-speed networks (1995)

A control architecture for a high-speed packet-switched network is described. The architecture was designed and implemented as part of the PARIS (subsequently plaNET and BBNS) networking project at IBM. This high bandwidth network for integrated communication (data, voice, video) is currently operational as a laboratory prototype. It will also be deployed within the AURORA Testbed that is part of the NSF/DARPA gigabit networking program. The high bandwidth dictates the need for specialized hardware to support faster packet handling for both point-to-point and multicast connections. A faster and more efficient network control is also required in order to support the increased number of connections and their changing requirements with time. The new network control architecture presented exploits specialized hardware, thereby enabling tasks to be performed faster and with less computation overhead. In particular, since control information can be distributed quickly using hardware packet handling mechanisms, decisions can be made based upon more complete and accurate information. In some respects, this has the effect of having the benefits of centralized control (e.g., easier bandwidth resource allocation to connections), while retaining the fault tolerance and scalability of a distributed architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
On Tolerating the Unreasonable (2001)

Philosophy, Tufts University, USA
Sense, Reference and Hybridity: Reflections on Kripke's Recent Reading of Frege (2010)

In his paper on ‘Frege's Theory of Sense and Reference’ Saul Kripke remarks: “Like the present account, Kunne stresses that for Frege times, persons, etc. can be part of the expression of the thought. However, his reading is certainly not mine in significant respects . . .”. On both counts, he is right. As regards the differences between our readings, in some respects I shall confess to having made a mistake, in several others I shall remain stubbornly unmoved. Thus I shall insist on the need for distinguishing Fregean sense from linguistic (lexico-grammatical) meaning, I shall resist Kripke's function-theoretic account of ‘hybrid’ thought-expressions, and I shall deplore his transformation of Gottlob Frege into Gottrand Fressell. As regards this transformation, I shall argue that some of the main points Kripke wants to drive home do not depend on it.
Stability of Anthocyanin from Mulberry Extracts in Alginate Microspheres at High Temperature (2012)

The aim of this study was to investigate stabilities of anthocyanins from mulberry fruits extracts in alginate microspheres. The total anthocyanins contents measured from water extracts of mulberry fruits (Chiangmai/Jul cultivars) were at 10.46±0.51 mg/g DW and 15.31±0.86 mg/g DW (Chiangmai/Korat cultivars). At high temperature the extracts lost their anthocyanin contents to 52%wt (at 100°C for 5 hour) and 73%wt (at 121°C for 20 min). Alginate microspheres were prepared using external gelation methods. Sodium alginate solution (2.5%w/v) was sprayed into CaCl 2 solution (0.1M) through a nozzle at N 2 flow rates of 20 L/min. The average bead sizes were at 342.03±3.21µm. Anthocyanins loading on alginate microspheres were at 2.283±0.15 mg/g dry weight. At 80(10h), 100(5h) and 121°C(20min), Anthocyanins retention were at 91%wt, 82%wt and 89%wt, respectively. Adsorption of anthocyanins from mulberry fruit extracts on alginate microspheres resulted in a greater stability at high temperature than that of the free anthocyanins.
Antibacterial Composite Film-Based Triboelectric Nanogenerator for Harvesting Walking Energy (2017)

As a green and eco-friendly technology, triboelectric nanogenerator (TENG) can harvest energy from human motion to generate electricity, so TENGs have been widely applied in wearable electronic devices to replace traditional batteries. However, the surface of these TENGs is easily contaminated and breeds bacteria, which is a threat to human health. Here, we report an antibacterial composite film-based triboelectric nanogenerator (ACF-TENG) that uses Ag-exchanged zeolite (Ag-zeolite) and polypropylene (PP) composite film as the triboelectric layer. Adding a small amount of Ag-zeolite with excellent antibacterial properties can increase the dielectric permittivity and improve the surface charge density of composite films, which enhances the output performance of the ACF-TENG. The open-circuit voltage (V<sub>OC</sub>), short-circuit current (I<sub>SC</sub>), and transferred charge (Q<sub>Tr</sub>) of the ACF-TENG are about 193.3, 225.4, and 233.3% of those of a pure PP film-based TENG, respectively. Because of the silver in the Ag-zeolite, the ACF-TENG can effectively kill Escherichia coli and fungi. When used in insoles, the ACF-TENG can resist the athlete's foot fungus effectively and work as a power source to light up light-emitting diodes and charge capacitors. The ACF-TENG has wide application prospects in self-powered medical and healthcare electronics.
Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors (2006)

The synthesis of a novel series of quinazolines substituted at C4 by five-membered ring aminoheterocycles is reported. Their in vitro structure-activity relationships versus Aurora A and B serine-threonine kinases is discussed. Our results demonstrate that quinazolines with a substituted aminothiazole at C4 possess potent Aurora A and B inhibitory activity and excellent selectivity against a panel of various serine-threonine and tyrosine kinases, as exemplified by compound 46. We found also that the position and nature of the substituent on the thiazole play key roles in cellular potency. Compounds with an acetanilide substituent at C5' have the greatest cellular activity. The importance of the C5' position for substitution has been rationalized by ab initio molecular orbital calculations. Results show that the planar conformation with the sulfur of the thiazole next to the quinazoline N-3 is strongly favored over the other possible planar conformation. Compound 46 is a potent suppressor of the expression of phospho-histone H3 in tumor cells in vitro as well as in vivo, where 46, administered as its phosphate prodrug 54, suppresses the expression of phospho-histone H3 in subcutaneously implanted tumors in nude mice.
Attempted assembly of discrete coordination complexes into 1-D chains using halogen bonding or halogen⋯halogen interactions (2007)

Attempts at creating infinite 1-D architectures using M(II)-acac complexes as building blocks and halogen bonding or halogen⋯halogen contacts failed to produce the desired motifs, and serve to illustrate how intermolecular interactions can be ranked in terms of their structural influence and supramolecular effectiveness.
Mixed-mode correlator for micropower acoustic transient classification (1999)

A mixed-mode very large scale integration (VLSI) processor for acoustic transient classification performs a running correlation between a time-frequency decomposed analog input signal and a corresponding template. Differential encoding of the inputs allows simplification of the multiply-and-accumulate operations, operating on binary templates and positive-valued inputs, implemented in current mode with eight MOS transistors per cell including SRAM template storage. The use of a bucket-brigade device (BED) instead of a charge-coupled device (CCD) for shift-and-accumulate operations allows long integration times necessary for acoustic transients spanning several hundred milliseconds. Correlated double sampling at the output compensates for dark current losses in the BED and other common-mode effects. The 64/spl times/16 time-frequency correlator measures 700 /spl mu/m/spl times/1170 /spl mu/m in a 1.2-/spl mu/m CMOS process and dissipates an average of 30 /spl mu/W in continuous operation.
SYNTHESIS AND CRYSTAL STRUCTURE OF MERCURY COMPLEX OF SACCHARIN WITH PYRIDINE (Hg(sac)2(py)2) (2007)

The structure of the mercury saccharinate complex with pyridine has been studied by IR and single crystal X-ray diffraction methods. The compound was crystallized in the monoclinic space group P21/n with unit cell dimensions of a = 9.8114(2), b = 21.2444(3), c = 12.0557(5), β = 97.8431(8) o , Z = 4, and the crystal structure was solved to an R value of 0.0425 for 5700 observations. The Hg atom has slightly distorted tetrahedral configuration with four nitrogen (N) atoms from two pyridine and two saccharinate anions in the complex.
The Physiologic Profile Of Ultra-endurance Competitors In Comparison To Healthy Controls (2011)

Despite an increase in the prevalence of sedentary behaviour and obesity amongst the general population, participation rates in ultra-endurance events (e.g., 100 mile endurance runs) have increased markedly in recent years. There is a widely held belief that ultra-endurance events are no longer completed by just elite endurance athletes and that a greater proportion of the average population is attempting these feats of endurance. PURPOSE: To determine if the physiological profiles of competitors in an ultra-endurance trail running race differ from their inactive counterparts. METHODS: We collected anthropometric and cardiovascular measures on participants (n=32, 19M,13F) competing in an ultra-endurance mountain trail running race (either 100 km or 100 mile). Control participants were matched based on ethnicity, age, and sex. RESULTS: A significant difference was found for weight and waist girth with controls being larger (10 cm) and heavier (∼9.5 kg) than runners. Participants in the longer, but not shorter, race distance had a lower BMI compared to norms (p = 0.04). Race participants had significantly higher systolic and diastolic blood pressures (p < 0.01), similar resting heart rate and no difference in arterial compliance. Preliminary data suggests that VO2max values may be somewhat elevated considering age and gender comparisons. CONCLUSION: Participants in the ultra-endurance race revealed alterations in anthropometry expected to occur from exercise training and proper diet. However, expected alterations in cardiovascular measures were not apparent. Further research is required to understand the implications of these findings.
Successive Detection of Zinc Ion and Citrate Using a Schiff Base Chemosensor for Enhanced Prostate Cancer Diagnosis in Biosystems (2021)

Sensitive and quantitative detection of prostate cancer (PC) requires a chemosensor with an applicable sensing strategy. A star-shaped Schiff base triaminoguanidine-integrated thiophene fluorophore TAT was rationally designed with nitrogen and sulfur atoms to coordinate with Zn<sup>2+</sup> as the initial step and to chelate with citrate as the following step. Formation of the complex TAT-Zn<sup>2+</sup> induced an intramolecular charge transfer and caused a red-shifted, Zn<sup>2+</sup> concentration-dependent fluorescence at 507 nm. Chelation of TAT-Zn<sup>2+</sup> with citrate led to an emission band at 692 nm upon an aggregation-induced emission mechanism. The distinctive fluorescence emissions of Zn<sup>2+</sup> and citrate biomarkers were demonstrated first in on-site paper-based test strips showing gradually enhanced colors at yellow and red channels and second in both <i>in vitro</i> and <i>in vivo</i> by using PC3 cells and BALB/c nude mouse animal models, respectively. The <i>in vitro</i> test confirmed the mitochondria organelle-targeting property of TAT, and the <i>in vivo</i> performance manifested the successful application of the probe in recognizing the prostate cancer. This is the first applicable chemosensor that could be in continuous recognition of dual PC biomarkers Zn<sup>2+</sup> and citrate in cancer diagnosis with a mitochondria organelle-targeting ability.