gebhart/patrepeval huggingface dataset:
Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice. (1985)

The morphogenesis of pulmonary edema and bronchiolar injury induced by the toxic furan, 4-ipomeanol, was studied by combined light and transmission electron microscopy. Weanling male CD-1 mice received 47 mg 4-ipomeanol/kg body weight by intraperitoneal injection and were studied at intervals from 2 to 360 hours after treatment. Interstitial edema associated with damaged endothelial cells was observed as early as 2 hours after treatment. The most severe endothelial damage was observed from 12 to 24 hours after treatment and occurred in association with alveolar edema. Capillary endothelial cell damage was characterized by marked dilation of endoplasmic reticulum and perinuclear envelopes, marked swelling of mitochondria, separation of cytoplasmic processes from other endothelial cells and their basal laminae, and occasional disruptions in the plasmalemma. Endothelial cell lesions in small caliber veins were similar but less pronounced as compared with the alterations observed in capillary endothelium. Minimal changes were present in alveolar epithelial cells. Damage to nonciliated bronchiolar epithelial cells was first observed at 4 hours after injection. The most severe changes in nonciliated cells occurred from 36 to 48 hours after treatment and included swelling of endoplasmic reticulum, necrosis, and sloughing. There was also necrosis and sloughing of ciliated bronchiolar epithelial cells. Endothelial and bronchiolar epithelial repair and resolution of the alveolar edema were complete by 240 hours after treatment. It is concluded that the endothelium lining capillaries and small veins, in addition to the nonciliated bronchiolar epithelial cell, are early targets in the development of 4-ipomeanol toxicity in the mouse and that the endothelial cell injury plays a major role in the development of pulmonary edema in this species. The results further suggest the possibility that pulmonary endothelial cells have the capability of metabolizing xenobiotic compounds such as 4-ipomeanol to form ultimate toxins.
Studies on Syntheses and Derivatives of Boron Hydride Systems (1988)

Abstract : Studies of reaction pathways in the conversion of B5H9 to (B9H14) resulted in maximizing the yield of (B9H14) and close to quantitative synthesis of B11H14. The (B9H13) dianion derived from (B9H14) has been synthesized and characterized. The heteraboranes (B11H11AlCH3)2, B11H11PCH3, and B10H12PCH3 derived form (B11H14) have been synthesized and characterized. Alkali metal reductions of B5H9 and THFBH3 result in the dianions (B5H9)2 and (BH3)2. A cage expansion reaction has produced a 10 vertex arachino-C2B8 carborane. The lanthanides Yb, Eu, Sm reduce B10H14 to form lanthanide boranes precursors of lanthanide borides. Reduction of the boron nitride precursor Cl3B3N3H3 has been investigated. Pentaborane, borane anions, aluminaborane, phosphaborane, boron nitride precursor, lanthanide borane.
Swift after Horace (2019)

Despite his career-long interest in Horace, Swift did not write formal “imitations” in the extensive manner in which Dryden or Pope did. This might in part explain the relative neglect of his Horatian poems in Swift studies and in surveys of literary translation of the period. In many of these poems, such as “The First Ode of the Second Book Paraphrased,” “Part of the Seventh Epistle of the First Book of Horace Imitated,” “Horace, Lib 2, Sat 6. Part of it Imitated,” “To the Earl of Oxford … out of Horace,” and “Toland’s Invitation to Dismal … Imitated from Horace,” Swift deals with parts, not wholes. In “Horace, Book I, Ode XIV,” by contrast, he engrafts onto the original striking new material, including a primer for his implied readership. While earlier critics have examined Swift’s Horatian poems in terms of the theory and practice of literary translation, this essay shifts the focus onto the translator rather than the translation, the persona rather than the paraphrased. Thus, it works towards a larger study of Swift’s appropriative poetics beyond formal imitation.
Social-K: Real-time K-anonymity guarantees for social network applications (2010)

Traditional approaches to K-anonymity provide privacy guarantees over publicly released data sets with specified quasi-identifiers. However, the most common public releases of personal data are now done through social networks and their APIs, which do not fit the previous research-centric data set release model, nor do they allow for clear assumptions about quasi-identifiers. This paper proposes a new definition of K-anonymity that suggests a practical way in which social networks could provide privacy guarantees to users of their API. To support as wide a range of applications as possible, the proposed privacy guarantee assumes all social-networking data may be a quasi-identifier and does not assume that data may be generalized and still be useful. Using the Facebook social networking API, we implement an application to demonstrate that providing such guarantees in real-time is feasible for real social networking data.
Vitamin D metabolites in renal insufficiency and other vitamin D disorders of children. (1983)

Serum vitamin D metabolites were measured in relation to factors responsible for the synthesis of 1,25(OH)2D in children with renal disease and other disorders of vitamin D metabolism. Severe renal failure (CCr less than 15 ml/min/1.73 m2) was associated with a reduction in 1,25(OH)2D to 25% of mean normal levels, a very high PTH/1,25(OH)2D ratio of 75 (normal = 0.74), and a 60% reduction of serum 24,25(OH)2D. At CCr values between 15 and 50 ml/min 1.73 m2, 1,25(OH)2D was 50% of normal, despite a PTH/1,25(OH)2D ratio of 7 and a normal 24,25(OH)2D value. Above clearance values of 75 ml/min/1.73 m2, 1,25(OH)2D and the ratio were normal. Oral 1,25(OH)2D therapy in severe chronic renal insufficiency caused a fall in this ratio from 75 to 8. High PTH/1,25(OH)2D ratios were found in hypophosphatemic rickets and vitamin D-deficiency rickets, indicating reduced synthesis of 1,25(OH)2D relative to PTH. Low ratios were found in hypoparathyroidism and sarcoidosis, possibly indicating independence of PTH stimulation in 1,25(OH)2D production. The ratios of calcium/1,25(OH)2D and phosphate/1,25(OH)2D also provided useful information in each of these conditions, indicating that the use of such series of ratios in selected patients may promote a better understanding of pathogenic mechanisms and of the response to therapy.
Effect of octreotide on growth hormone, IGF-I, IGFBP-3, glucagon, cortisol and epinephrine response to insulin-induced hypoglycaemia in insulin-dependent diabetic patients. (1997)

The purpose of the study was to investigate the effects of octreotide on the response of counterregulatory hormones to insulin-induced hypoglycaemia in 9 Type 1 diabetic patients without autonomic neuropathy. During an euglycaemic clamp, saline or octreotide (50 mcg) was randomly injected subcutaneously. Patients were then clamped to hypoglycaemic levels (2.5 mmol/l), and hormonal response was evaluated after 30 min of hypoglycaemia. Although octreotide suppressed both GH (0.5 +/- 0.01 vs 9.5 +/- 0.9 ng/ml, p < 0.001) and glucagon (110 +/- 9 vs 165 +/- 10 pg/ml, p < 0.05) responses, it did not affect cortisol, epinephrine, IGF-1 and IGFBP-3 levels. The time required for recovery from hypoglycaemia was longer after octreotide (19.1 +/- 1.2 min vs 14.3 +/- 0.9 min, p < 0.05), and a greater amount of infused glucose was needed to reach normoglycaemia (g 24.6 +/- 1.2 vs 17.7 +/- 1.3, p < 0.05). These findings suggest that administration of octreotide to insulin-treated Type 1 diabetic patients may impair anti-hypoglycaemic counterregulatory mechanisms through suppression of glucagon and GH responses.
The first report on mushroom green mould disease in Croatia. (2012)

Green mould disease, caused by Trichoderma species, is a severe problem for mushroom growers worldwide, including Croatia. Trichoderma strains were isolated from green mould-affected Agaricus bisporus (button or common mushroom) compost and Pleurotus ostreatus (oyster mushroom) substrate samples collected from Croatian mushroom farms. The causal agents of green mould disease in the oyster mushroom were T. pleurotum and T. pleuroticola, similar to other countries. At the same time, the pathogen of A. bisporus was exclusively the species T. harzianum, which is different from earlier findings and indicates that the range of mushroom pathogens is widening. The temperature profiles of the isolates and their hosts overlapped, thus no range was found that would allow optimal growth of the mushrooms without mould contamination. Ferulic acid and certain phenolic compounds, such as thymol showed remarkable fungistatic effect on the Trichoderma isolates, but inhibited the host mushrooms as well. However, commercial fungicides prochloraz and carbendazim were effective agents for pest management. This is the first report on green mould disease of cultivated mushrooms in Croatia.
Parkinson, John S. • 1907–1987 (1988)

First Page
Pantherinine, a Cytotoxic Aromatic Alkaloid, and 7-Deazainosine from the Ascidian Aplidium pantherinum (1993)

A new cytotoxic aromatic alkaloid, pantherinine [1], and a mixture of nucleosides including 7-deazainosine [3], have been isolated from the ascidian Aplidium pantherinum collected at Stenhouse Bay, South Australia. The structures were determined primarily from 1H- and 13C-nmr data, especially one-bond and multiple-bond proton-carbon correlations. Although 7-deazainosine [3] has been known as a synthetic compound for several decades, this appears to be the first report of its isolation as a natural product.
VP38.03: Fetal lung assessment using T2*‐MR in intrauterine growth restriction (2020)

Novel non-invasive T2*-magnetic resonance (MR) sequences have been used to assess placental health by detecting the differences in signal given by oxygenated and deoxygenated regions within the same tissue. We aimed to explore the feasibility of T2*-MR to study the fetal lung in a subset of cases with intrauterine growth restriction (IUGR). Prospective cohort of singleton pregnancies including IUGR (defined by birthweight below 10th centile together with abnormal feto-placental Doppler) and normally grown fetuses paired by gestational age at T2*-MR acquisition (25-37 weeks of gestation). Acquisitions were made in basal conditions and during maternal hyperoxygenation. Regions of interest (ROI) of the lung were drawn manually and analysed to obtain T2* values. Out of a total of 47 acquisitions, fetal lung T2* could be analysed in 23 IUGR and 10 normally grown fetuses (70% of the overall acquisitions). Mean gestational age at acquisition was 32 weeks (29-35 weeks) both in cases and controls. A non-significant tendency to lower T2* values in the lung (basal and after maternal hyperoxygenation) could be observed in IUGR when compared with normally grown fetuses (figure 1). These results suggest that there may exist a hypoxic environment in the lung of IUGR fetuses. T2*-MR seems to be a promising tool for the assessment of the lung in this population offering complementary information about its development. Supporting information can be found in the online version of this abstract Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Polycarbonate Glazing - Accelerated Wiper Testing, Surface Characterization and Comparison with On-Road Fleet Data (2012)

Exatec® PC glazing technology team, has developed advanced weathering and abrasion resistant coatings technology that can be applied to protect polycarbonate. It is of particular interest to quantify and understand the factors that determine the surface abrasion performance of coated PC in rear window and backlight applications that have a wiper system. In the present study we describe Exatec's lab scale wiper testing equipment and test protocols. We also describe adaptation of optical imaging system to measure contrast and nano-profiling using nano-indenter, as post wiper surface characterization methods. These methods are more sensitive to fine scratches on glazing surface than standard haze measurement and mechanical profilometry. Three coating systems were investigated; Siloxane wetcoat (A), Siloxane wetcoat (B), and Siloxane wetcoat (B) plus plasma coat (Exatec® E900 coating). The performance comparisons were made using all these surface characterization methods. In one study, both wetcoat A and plasma coat show similar wiper abrasion performance with water only and performance is similar to glass after 500K cycle of wiper abrasion testing. Wetcoat systems alone may be enough to withstand environmental conditions where windows do not require a wiper. Exatec® plasma coatings, in another study using a slurry solution instead of water alone, shows superior performance compared to wetcoat and performance is comparable to glass. Hence the Exatec® E900 plasma coated glazing system can be a more suitable candidate for rear windows with wiper attached to it. Test results obtained with lab scale wiper tester have been correlated with on-road fleet vehicle data to help develop appropriate specifications of accelerated wiper abrasion testing for PC glazing.
Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity (2015)

Alginates are classed as a dietary fibre and have been shown to inhibit digestive enzymes <i>in vitro</i>, and therefore could be used as an obesity treatment. The current study aims to assess whether alginate in a bread vehicle maintains its inhibition properties despite cooking and digestion, and may therefore be used as a potential treatment for obesity. After 180 min in a model gut that replicates digestion in the mouth, stomach and small intestines alginate bread (AB), control bread (CB), CB with Manucol<sup>®</sup> DM alginate, free DM alginate and model gut solution were collected. DM, LFR 5/60 and SF200 were heated at 37 °C and 200 °C, with DM also heated at 50, 100 and 150 °C. Samples from the model gut and heated alginate were assessed for molecular size and inhibition properties using viscosity, gel filtration and a lipase turbidity assay. AB does not significantly increase viscosity in the model gut. Viscosity of alginate reduces beyond 100 °C, although alginate retains its inhibition properties up to 150 °C. Cooking into the bread does not reduce the molecular size of the alginate or affect its inhibition properties. These data demonstrate the robustness of alginates lipase inhibition despite the cooking process and digestion. Therefore adding alginate to a bread vehicle may have the potential in the treatment for obesity.
Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries (2012)

Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field.
Control of Sweetpotato Whitefly, Tomato Pinworm, and American Serpentine Leafminer on Staked Tomato, Fall 1991 (1993)

Abstract Twelve, 3 ft by 240 ft beds on 6 ft centers were planted with ‘Sunny’ tomatoes spaced 20 inches apart on 22 Oct. Standard cultural practices were followed for staked, seep-irrigated tomatoes in southwest Florida. Dipel 2 X was applied as needed for control of armyworms. Experimental design was randomized complete block with 4 replications. Each block consisted of 3 rows with each replicate plot comprised of 3 rows 23 ft in length. There were 10 treatments plus an unsprayed control. Five weekly applications were made, beginning on 5 Dec. A single boom plot sprayer equipped with drops fitted with Albuz ATR lilac ceramic tips was operated at 400 psi. Each drop had 3 nozzles, for a total of 6 per row. Average delivery per nozzle was 0.194 gal/min; total delivery rate was 54 gal/acre. SPWF and LM immatures, LM stings, and completed mines were monitored weekly with a random sampling of 3 terminal leaflets from three 6th Leaves (from the top) per plot, 1 per row. Leaf area was determined with a leaf area meter to obtain values for SPWF per cm2. Adult SPWF were counted from one, 3-inch sq yellow card trap exposed for 24 hr (one card per row). Fruit was harvested twice, weighted and counted by USDA size categories, culled and checked for TPW damage.
Effect of anthropometric adjustments on BMD and BMC Z-scores in a population of prader-willi syndrome pediatric patients (2014)

Two adjustment models were applied to a dataset of bone-mineral density (BMD) and bone-mineral content (BMC) from dual-energy x-ray absorptiometry (DXA) measurements of pediatric patients with Prader-Willi Syndrome (PWS). One model used weight, height and % body fat (WHF) in the calculation of Z-scores in addition to race, sex and age already included in the standard model. As percent body fat is not always available, a second model with only weight and height was also examined (WH).
Influenza – our constant companion (2011)

On 11 June 2009, Dr Margaret Chan, the Director-General of the World Health Organization, announced to the world that following the emergence of a novel influenza A virus in late April 2009 and its extensive spread that, “I have therefore decided to raise the level of influenza pandemic alert from phase 5 to phase 6. The world is now at the start of the 2009 influenza pandemic.” Dr Chan also commented, “No previous pandemic has been detected so early or watched so closely, in real-time, right at the very beginning. The world can now reap the benefits of investments, over the last five years, in pandemic preparedness.” Also observed was that, “Globally, we have good reason to believe that this pandemic, at least in its early days, will be of moderate severity”.
Characterization of apolipoprotein A-I as a potential biomarker for cholangiocarcinoma (2009)

Serum samples from 60 cholangiocarcinoma (CC), 60 benign diseases of hepatobiliary and 53 normal individuals were analysed by SELDI-TOF-MS (Surface Enhanced Laser Desorption/Ionization Time of Flight Mass Spectrometry). It was found that a 28 k m/z peak was significantly decreased in CC and retained discriminatory value between CC and normal group, also between CC and benign groups. Then 1-D, 2-D gel electrophoresis and tandem mass spectroscopy were employed to isolate and identify the protein that correlates with observed SELDI-TOF-MS (m/z) value. The results demonstrated that 28 k m/z peak was apolipoprotein A-I (ApoA-I) and its identity was further validated by immunodepletion and Western blotting analysis. Subsequently, it was inspiring found that the decreased level of ApoA-I analysed by enzyme linked immunosorbent assay was consistent with SELDI-TOF-MS analysis. Therefore, it suggested that ApoA-I could be a potential useful biomarker for CC.
METABOLISM OF ACETIC ACID IN KIDNEY AND LIVER SLICES OF THE HYPOTHYROID RATS (1955)

HYPOTHYROIDISM causes depression of various enzymatic process and O2 consumption of the tissues (Boreld and Holmgreen, 1948; Tipton and Nixon, 1946). It also induces hypercholesterolemia, rise in liver cholesterol (Handler, 1948) and caracass cholesterol (Kennely and Maynard, 1952). A rise of volatile fatty acids (which include 90% acetic acid), acetone bodies and cholesterol with a depression of succinic and lactic dehydrogenase activity have been observed by the authors (1954) in the tissues of hypothyroid rats even when the effects of unequal food intake was neutralised. Acetate and acetoacetate are the basic materials for cholesterol synthesis (Brady and Gurin, 1951) and they are oxidized through the tricarboxylic acid cycle (Krebs, 1943; Krebs and Jhonson, 1937). Besides liver, kidney oxidises acetates very rapidly, forms acetoacetate (Medes et al., 1945a, 1945b) and also sjmthesises cholesterol (Srere, 1950). So all these facts make the metabolism of acetic acid a logical choice for study in liver and kidney of hypothyroidism induced rats to throw further light into the mechanism of cholesterol synthesis from its precursors.
On-line Market Research (2001)

This article focuses upon innovation and issues in on-line market research. On-line research, on-line consumer behavior, and e-commerce are new areas of academic study in marketing. Most of the early work in these areas was done by practitioners, as illustrated by research reports and case studies presented at professional conferences. The present article reviews technologies and methods of on-line research and points to various methodological and ethical issues. On-line research is evaluated from two perspectives: orthodox thinking about the validity of research, and out-of-the-box thinking about how on-line research can increase the impact of market research and develop the core competitive capabilities of firms. Further academic research and learning from the data of on-line research and electronic commerce are encouraged.
Irradiation behavior of the CNEA's experimental uranium silicide dispersion fuel plates (1988)

Since 1978 the CNEA ECBE project has been involved in the development of dispersion fuel plates with four types of fuel materials -- UAl{sub x}, U{sub 3}O{sub 8}, U{sub 3}Si, and U{sub 3}Si{sub 2} -- to be used in low enriched (LEU < 20% {sup 235}U) fuel elements for research reactors. Miniplates with these fuel materials were manufactured at CNEA and were irradiated in the ORR in three series of irradiations as part of the RERTR miniplate irradiation program. The first irradiation contained U{sub 3}O{sub 8} and UAl{sub x} fuel, the second U{sub 3}O{sub 8}, UAl{sub x} and U{sub 3}Si, while the third irradiation test consisted of six U{sub 3}Si{sub 2} miniplates and one U{sub 3}Si miniplate. This third test is the subject of this paper. The present results compare favorably with other irradiations performed in the RERTR program{sup 1,2} showing in particular the excellent behavior of the U{sub 3}Si{sub 2}. The overall data accumulated support the qualification of the CNEA fabrication techniques. 5 refs., 13 figs., 3 tabs.
Mapping and scheduling of dataflow graphs &#x2014; A systematic map (2014)

Dataflow is a natural way of modelling streaming applications, such as multimedia, networking and other signal processing applications. In order to cope with the computational and parallelism demands of such streaming applications, multiprocessor systems are replacing uniprocessor systems. Mapping and scheduling these applications on multiprocessor systems are crucial elements for efficient implementation in terms of latency, throughput, power and energy consumption etc. Performance of streaming applications running on multiprocessor systems may widely vary with mapping and scheduling strategy. This paper performs a systematic literature review of available research carried out in the area of mapping and scheduling of dataflow graphs.