gebhart/patrepeval huggingface dataset:
Metal bis{(trifluoromethyl)sulfonyl}amide complexes: highly efficient Friedel–Crafts acylation catalysts (2004)

A range of metal bis[(trifluoromethyl)sulfonyl]amide complexes, including many unreported ones, have been synthesised, most of which have been found to be excellent Friedel-Crafts acylation catalysts in the absence of solvent; these reactions have also been carried out in ionic liquids, which allow the catalysts to be recycled and reused.
Four-pole galvanic vestibular stimulation causes body sway about three axes (2015)

Abstract Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional studies used a two-pole GVS, in which electrodes are placed behind each ear, or a three-pole GVS, in which an additional electrode is placed on the forehead. These stimulation methods can be used to induce virtual head roll and pitch motions when a subject is looking upright. Here, we proved our hypothesis that there are current paths between the forehead and mastoids in the head and show that our invented GVS system using four electrodes succeeded in inducing directional virtual head motion around three perpendicular axes containing yaw rotation by applying different current patterns. Our novel method produced subjective virtual head yaw motions and evoked yaw rotational body sway in participants. These results support the existence of three isolated current paths located between the mastoids and between the left and right mastoids and the forehead. Our findings show that by using these current paths, the generation of an additional virtual head yaw motion is possible.
RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer (2010)

Esophageal cancer is one of the most frequently occurring cancers in the world. Targeting therapy strategy of cancer with specific inhibitors is developing and has showed promising antitumor efficacy. It is known that mTOR is an important controller of cell growth. RAD001 (everolimus) is a specific inhibitor of mTOR that can block the mTOR signaling pathway. The purposes of this study was to explore the inhibitory effects of RAD001 on mTOR signaling and the mechanism of cell growth suppression by RAD001. We examined both the expression of mTOR, p70S6K and S6 in SEG-1 esophageal cancer cells and KOB-13 normal esophageal epithelial cells and the efficacy of RAD001 against SEG-1 esophageal cancer cells. mTOR, p70S6K and S6 were overexpressed in SEG-1 esophageal cancer cells compared with KOB-13 normal esophageal epithelial cells. SEG-1 esophageal cancer cells were sensitive to RAD001. The survival rate of the cells treated with RAD001 over 0.33 microM was significantly different compared with that of control (P<0.01). RAD001 inhibited the phosphorylation of mTOR (Ser2448) and S6 (Ser240/244) in different grades and the expressions of mTOR, p70S6K and S6. As a result, RAD001 induced a dose-dependent decrease in cell proliferation, G1/S arrest and damage of cell shape. Taken together, these data showed that RAD001 can inhibit mTOR signaling and proliferation in SEG-1 esophageal cancer cells in vitro. It offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer.
Pupil and Lip Detection using Shape and Weighted Vector based on Shape (2002)

In this paper, we propose an efficient method for recognizing pupils and lip in a human face. Pupils are detected by a cost function, which uses features based on the eye's shape and a relation between pupil and eyebrow. The inner boundary of lip is detected by weighted vectors based on lip's shape and on the difference of gray level between lip and face skin. These vectors extract four feature points of lip : the top of the upper lip, the bottom of the lower lip, and the two corners. The experiments have been performed for many images and show very encouraging result.
A novel splice variant ofHER2 with increased transformation activity (1998)

The HER2 proto-oncogene (also known as neu or c-erbB-2) belongs to the epidermal growth factor receptor family. HER2 is frequently amplified in human carcinomas. Gene amplification or overexpression of HER2 has been correlated with poor prognosis in several human cancers. Point mutation in the rat HER2 homolog, neu, is involved in the formation of rat neuroblastomas. However, no similar mutation in HER2 has been found in human cancers. Here we report the identification of a novel alternative splicing form of HER2 (deltaHER2) in human cell lines. An exon 16 amino acids long in the extracellular domain was deleted in deltaHER2. Deletion mutations in the corresponding region were shown previously to be involved in the formation of mammary carcinomas in transgenic mice. In the focus-formation assay, deltaHER2 showed much stronger transformation activity than did wild-type HER2. This result suggests that the deleted 16-amino acid exon may play a regulatory role in HER2 transformation activity.
Synthesis, Structures And Properties Of Cyclopenteno Annelated Bis-Fused TTF Donors And Their Molecular Complexes (1997)

Abstract A series of cyclopenteno annelated bis-fused TTF derivatives (CP-TTP 1a-d) have been synthesized. The present donors have produced many molecular complexes showing high conductivity. In particular, several cation radical salts based on the bis(methylthio)- (CPTM-TTP 1c) and ethylenedithio (CPET-TTP, 1d) derivatives are metallic down to liquid helium temperature, though resistivity of CPTM-TTP salts increases a little at low temperature. Among metallic salts, (CPTM-TTP)4X (X = PF6 −, AsF6 − and SbF6 −) are isostructural and have two-dimensional “β-type” arrangement of donor molecules. The band calculations of these salts indicate they have eclipsed Fermi surfaces characteristic of two-dimensional metals.
NMR instabilities and spectral clustering in laser-polarized liquid xenon (2001)

To study how highly magnetized liquids behave in NMR experiments, we have performed low-field NMR on laser-polarized liquid ${}^{129}\mathrm{Xe},$ with nuclear polarization of up to 6%. Contrary to conventional NMR results, we find that instabilities develop after a large pulse, leading to an unexpectedly abrupt decay of the signal. In contrast, the NMR spectrum after a small pulse collapses to a series of unusually sharp lines (spectral clustering), whose widths correspond to precession lifetimes longer than a half minute. We discuss the key role of long-range dipolar coupling in such spin dynamics.
Genetic algorithms for MRI magnet design (2002)

Continuing advances in the field of parallel computing have allowed nonlinear optimization techniques to be applied to many problems previously considered too computationally demanding. We describe a general magnet design software package, CamGASP, which uses genetic algorithms (GAs) for the design of large whole-body MRI systems. The method of GAS allows a population of many designs to evolve with a bias toward the fittest designs continuing to later generations. Central to all nonlinear optimization techniques is the cost function, which decreases for designs that match the required specifications and are hence deemed to be "fitter". Multiple evaluations of the cost function are necessary to complete a single generation and this task can readily be shared across a network of processors, working in parallel. Thus GAs are especially suited to running on parallel computer systems. We present results of the performance of the GA software and also discuss methods for rapid calculation of magnetic fields from circular coils. We also present specific superconducting MRI magnet designs including a split coil optimized for simultaneous PET and MRI.
The CD8+ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-Term Immunity (2006)

We have previously reported that the CD8+ T cell response elicited by recombinant adenovirus vaccination displayed a delayed contraction in the spleen. In our current study, we demonstrate that this unusual kinetic is a general phenomenon observed in multiple tissues. Phenotypic analysis of transgene-specific CD8+ T cells present 30 days postimmunization with recombinant adenovirus revealed a population with evidence of partial exhaustion, suggesting that the cells had been chronically exposed to Ag. Although Ag expression could no longer be detected 3 wk after immunization, examination of Ag presentation within the draining lymph nodes demonstrated that APCs were loaded with Ag peptide for at least 40 days postimmunization, suggesting that Ag remains available to the system for a prolonged period, although the exact source of this Ag remains to be determined. At 60 days postimmunization, the CD8+ T cell population continued to exhibit a phenotype consistent with partially exhausted effector memory cells. Nonetheless, these CD8+ T cells conferred sterilizing immunity against virus challenge 7-12 wk postimmunization, suggesting that robust protective immunity can be provided by CD8+ T cells with an exhausted phenotype. These data demonstrate that prolonged exposure to Ag may not necessarily impair protective immunity and prompt a re-evaluation of the impact of persistent exposure to Ag on T cell function.
A packaged MOS power device with an integral protection chip (2003)

A packaged MOS power device having a protective integrated circuit mounted on the gate lead of the package is described. The protective circuit prevents gate overvoltage and provides for rapid gate discharge during commutation, overtemperature, or overvoltage in the on-state.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Exciton mediated ultrafast feature of hybrid 2D perovskite THz metadevice (2019)

We show exciton mediated ultrafast feature in 2D perovskite arises due to quantum confinement of free carriers. Integrating it with metamaterials exhibit 93 % modulation of terahertz field at ultrafast time scales (~ 20 ps).
Activation and Inhibition of Photoreceptor Guanylyl Cyclase by Guanylyl Cyclase Activating Protein 1 (GCAP-1) (2007)

Guanylyl cyclase activating protein 1 (GCAP-1), a Ca(2+)/Mg(2+) sensor protein that accelerates retinal guanylyl cyclase (RetGC) in the light and decelerates it in the dark, is inactive in cation-free form. Binding of Mg(2+) in EF-hands 2 and 3 was essential for RetGC activation in the conditions mimicking light adaptation. Mg(2+) binding in EF-hand 2 affected the conformation of a neighboring non-metal binding domain, EF-hand-1, and increased GCAP-1 affinity for RetGC nearly 40-fold compared with the metal-free EF-hand 2. Mg(2+) binding in EF-hand 3 increased GCAP-1 affinity for RetGC 5-fold and its maximal RetGC stimulation 2-fold. Mg(2+) binding in EF-hand 4 affected neither GCAP-1 affinity for RetGC, nor RetGC activation. Inactivation of Ca(2+) binding in EF-hand 4 was sufficient to render GCAP-1 a constitutive activator of RetGC, whereas the EF-hand 3 role in Ca(2+)-dependent deceleration of RetGC was likely to be through the neighboring EF-hand 4. Inactivation of Ca(2+) binding in EF-hand 2 affected cooperativity of RetGC inhibition by Ca(2+), but did not prevent the inhibition. We conclude that 1) Mg(2+) binding in EF-hands 2 and 3, but not EF-hand 4, is essential for the ability of GCAP-1 to activate RetGC in the light; 2) Mg(2+) or Ca(2+) binding in EF-hand 3 and especially in EF-hand 2 is required for high-affinity interaction with the cyclase and affects the conformation of the neighboring EF-hand 1, a domain required for targeting RetGC; and 3) RetGC inhibition is likely to be primarily caused by Ca(2+) binding in EF-hand 4.
Dietary supplementation with either saturated or unsaturated fatty acids does not affect the mechanoenergetics of the isolated rat heart (2014)

Abstract It is generally recognized that increased consumption of polyunsaturated fatty acids, fish oil (FO) in particular, is beneficial to cardiac and cardiovascular health, whereas equivalent consumption of saturated fats is deleterious. In this study, we explore this divergence, adopting a limited purview: The effect of dietary fatty acids on the mechanoenergetics of the isolated heart per se. Mechanical indices of interest include left-ventricular (LV) developed pressure, stroke work, cardiac output, coronary perfusion, and LV power. The principal energetic index is whole-heart oxygen consumption, which we subdivide into its active and basal moieties. The primary mechanoenergetic index of interest is cardiac efficiency, the ratio of work performance to metabolic energy expenditure. Wistar rats were divided into three Diet groups and fed, ad libitum, reference (REF), fish oil-supplemented (FO), or saturated fatty acid-supplemented (SFA) food for 6 weeks. At the end of the dietary period, hearts were excised, mounted in a working-heart rig, and their mechanoenergetic performance quantified over a range of preloads and afterloads. Analyses of Variance revealed no difference in any of the individual mechanoenergetic indices among the three Diet groups. In particular, we found no effect of prior dietary supplementation with either saturated or unsaturated fatty acids on the global efficiency of the heart.
Induction of Fibrinogen Expression in the Lung Epithelium duringPneumocystis cariniiPneumonia (1998)

Pneumocystis carinii is an important pulmonary pathogen responsible for morbidity and mortality in patients with AIDS. The acute-phase response (APR), the primary mechanism used by the body to restore homeostasis following infection, is characterized by increased levels of circulating fibrinogen (FBG). Although the liver is the primary site of increased FBG synthesis during the APR, we unexpectedly discovered that FBG is synthesized and secreted by lung alveolar epithelial cells in vitro during an inflammatory stimulus. Therefore, we sought to determine whether lung epithelial cells produce FBG in vivo using animal models of P. carinii pneumonia (PCP). Inflammation was noted by an influx of macrophages to P. carinii-infected alveoli. Northern hybridization revealed that gamma-FBG mRNA increased two- to fivefold in P. carinii-infected lung tissue, while RNA in situ hybridization demonstrated increased levels of gamma-FBG mRNA in the lung epithelium. Immunoelectron microscopy detected lung epithelial cell-specific production of FBG, suggesting induction of a localized inflammatory response resembling the APR. A systemic APR was confirmed by a two- to fivefold upregulation of the levels of hepatic gamma-FBG mRNA in animals with PCP, resulting in a corresponding increase in levels of FBG in plasma. Furthermore, immunoelectron microscopy revealed the presence of FBG at the junction of cell membranes of trophic forms of P. carinii organisms aggregated along the alveolar epithelium. These results implicate FBG in the pathogenesis of PCP in a manner similar to that of the adhesive glycoproteins fibronectin and vitronectin, which are known to participate in intra-alveolar aggregation of organisms and adherence of P. carinii to the lung epithelium.
The therapeutic potential of resveratrol: a review of clinical trials (2017)

Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms. While there is a wealth of in vitro and in vivo evidence that resveratrol could be a promising therapeutic agent, clinical trials must confirm its potential. In this work, we reviewed the current clinical data available regarding the pharmacological action of resveratrol. Most of the clinical trials of resveratrol have focused on cancer, neurological disorders, cardiovascular diseases, diabetes, non-alcoholic fatty liver disease (NAFLD), and obesity. We found that for neurological disorders, cardiovascular diseases, and diabetes, the current clinical trials show that resveratrol was well tolerated and beneficially influenced disease biomarkers. However resveratrol had ambiguous and sometimes even detrimental effects in certain types of cancers and in NAFLD. In most of the clinical trials, the major obstacle presented was resveratrol's poor bioavailability. Thus, this work provides useful considerations for the planning and design of future pre-clinical and clinical research on resveratrol.
Meshes and cubes : distributed scatternet formations for bluetooth personal area networks (2004)

The members of the Committee appointed to examine the thesis of ANIRUDDHA SHRIRAM DAPTARDAR find it satisfactory and recommend that it be accepted. ii Chair ACKNOWLEDGEMENT First and foremost, I would like to thank that eternal power which exists in this world, we call GOD, which has helped me in a number of ways. I have faced many challenges during this eventful journey and I am grateful to GOD for helping me come out of all those safe and sound. This thesis is dedicated to my family, Aai (Dr. Mrs. Vaidehi Daptardar), Baba (Mr. Shriram Daptardar) and my sweet younger sister, chingi (Ms. Sayali Daptardar). Without their love, support and motivation, I would not have reached this stage and this work would have been far from complete. Aai and Baba have always been more than a friend to me and have provided me with their valuable suggestions and shared their experience from time to time. They have shown me a path to walk on with their own footprints. They have given me the inspiration needed to face all the twists and turns of life with courage. The home-made food has always kept me healthy and
Formalizing governance in virtual districts (2003)

This paper presents a model that helps to specify patterns of control and coordination among different actors within a cooperative workflow. The paper explains how the model can be applied according to a methodological approach structured in three steps from requirements analysis to detailed design. A set of patterns is provided at each step to support specification activities. Patterns are designed by analyzing and modeling different mechanisms of governance among organizations.
Focused Lasing Through Dynamic Scattering Media (2013)

The ability to control light through dynamically varying heterogeneous media could be important for applications ranging from free-space communication to laser therapy. The underlying challenge is to control an optical wavefront with a large number of degrees-of-freedom (DOF) faster than the medium dynamics.
Reducing the impact of preterm birth: Preterm birth commissioning in the United Kingdom (2019)

Reducing preterm birth is a priority for Maternity and Children's services. In the recent UK Department of Health publication 'Safer Maternity Care' the Secretary of State for Health aimed to achieve the national maternity safety ambition by pledging to reduce the rate of preterm birth from 8% to 6%. It was proposed that specialist preterm birth services should be established in the UK in order to achieve this aim. In response the Preterm Clinical Network has written Commissioning Guidance aimed to establish best practice pathways and agreed models of care to reduce variation nationally. They have been developed by clinical experts in the field, from within the UK, to provide recommendations for commissioning groups and to recommend pathways to organisations with the aim of reducing the incidence of preterm birth. Three key areas of care provision are focused on: prediction, prevention and preparation of women at high risk of PTB. This Expert Opinion, will summarise the Commissioning Guidance.
Determination of surface recombination velocities of organic monolayers on silicon through Kelvin probe (2013)

We report the determination of the surface recombination velocity of electron-hole pairs for silicon samples passivated with organic monolayers using the Kelvin probe. The recombination velocity was determined from the surface photovoltage and incident photon flux. By scanning of the Kelvin probe tip over the sample, the change in surface recombination velocity can be measured allowing recombination lifetime mapping. Organic monolayers with different chain lengths and exhibiting various recombination lifetimes were synthesized through a two-step chlorination-alkylation technique. The estimated recombination lifetimes were compared against those obtained from an industrial standard technique and were found to be in good agreement.
Extending the security assertion markup language to support delegation for Web services and grid services (2005)

Users of Web and grid services often must temporarily delegate some or all of their rights to a software entity to perform actions on their behalf. The problem with the typical grid services approach (X. 509 proxy certificates) is that commercial Web services tooling fails to recognize these certificates or process them properly. The security assertion markup language (SAML) is a standardized XML-based framework for exchanging authentication, authorization and attribute information. SAML has broadening commercial support but lacks delegation capabilities. To address this shortcoming, we exploit SAML's inherent extensibility to create a delegation framework for Web and grid services that supports both direct and indirect delegation. We develop a set of verification rules for delegation tokens that rely on WS-Security X.509 signatures, but do not force any trust relationship between the delegatee and the target service. We have implemented the framework on two common Web service hosting environments: Java/Tomcat and .NET. By leveraging existing Web services standards, we make it easier for Grid practitioners to build and consume Web and grid services without resorting to grid-specific protocols.
Structure and bonding in M-X-M systems (M=Li, Na and K; X=O, S): Effects of charge-transfer (2008)

Structure and bonding for a series of oxo-bridged and sulphur bridged alkali-metal centers (M-X-M: Li, Na and K; X=O, S) are studied for various M-X-M angles. The structures for these charge-transfer systems are compared with H-X-H. These charge- tra
Supplementary Fig S5 from TAS-121, A Selective Mutant EGFR Inhibitor, Shows Activity Against Tumors Expressing Various <i>EGFR</i> Mutations Including T790M and Uncommon Mutations G719X (2023)

&lt;p&gt;Supplementary Fig. S5 shows anti-tumor effect of TAS-121 in HCC827 xenograft mouse models.&lt;/p&gt;
Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes (2016)

Borrowing hydrogen (or hydrogen autotransfer) reactions represent straightforward and sustainable C-N bond-forming processes. In general, precious metal-based catalysts are employed for this effective transformation. In recent years, the use of earth abundant and cheap non-noble metal catalysts for this process attracted considerable attention in the scientific community. Here we show that the selective N-alkylation of amines with alcohols can be catalysed by defined PNP manganese pincer complexes. A variety of substituted anilines are monoalkylated with different (hetero)aromatic and aliphatic alcohols even in the presence of other sensitive reducible functional groups. As a special highlight, we report the chemoselective monomethylation of primary amines using methanol under mild conditions.