gebhart/patrepeval huggingface dataset:
Molecular Description of the Formation and Structure of Plasticized Globular Protein Films (2005)

To optimize the properties of plasticized globular proteins films, a clear comprehension of the structure and molecular events occurring during film formation is required. In this work, the structural organization of beta-lactoglobulin (beta-lg) films plasticized with diethyelene glycol are investigated for the first time during the entire film formation process by attenuated total reflectance and transmission infrared spectroscopy. The films are made by a common two-step procedure consisting of a first heat treatment (80 degrees C/30 min) followed by the casting of the film-forming solution for dehydration. Heating at 80 degrees C leads to the self-aggregation of the proteins with a conversion of regular secondary structures into antiparallel beta-sheets. The kinetics of the conformational conversion shows that approximately 10% of the amino acids are involved in beta-sheets after the first step. Dehydration induces a further aggregation, with approximately 46% of the amino acids involved in beta-sheets in the final film. Water evaporation results in the association of the aggregates formed during the heating step. The presence of the plasticizer during water removal is essential as it allows specific conformational rearrangements into extended beta-sheets and ordering of the polypeptide chains. This work underlines that the assembly of building blocks is common in beta-lg networks and it emphasizes the widespread occurrence of beta-structures in synthetic and natural protein networks.
A intense-focused ultrasound tightening for the treatment of infraorbital laxity (2012)

IFUS can be used as a non-invasive, skin-tightening procedure for infraorbital laxity. No serious, permanent, or delayed side effects were noted up to 6 months post treatment. Thus, this procedure can be effective and safe in the treatment of decreased laxity of the lower eyelids.
Identification of a Domain in Human Immunodeficiency Virus Type 1 Rev That Is Required for Functional Activity and Modulates Association with Subnuclear Compartments Containing Splicing Factor SC35 (2000)

The activity of human immunodeficiency virus Rev as a regulator of viral mRNA expression is tightly linked to its ability to shuttle between the nucleus and cytoplasm; these properties are conferred by a leucine-rich nuclear export signal (NES) and by an arginine-rich nuclear localization signal/RNA binding domain (NLS/RBD) required for binding to the Rev-responsive element (RRE) located on viral unspliced and singly spliced mRNAs. Structure predictions and biophysical measurements indicate that Rev consists of an unstructured region followed by a helix-loop-helix motif containing the NLS/RBD and sequences directing multimerization and by a carboxy-terminal tail containing the NES. We present evidence that the loop portion of the helix-loop-helix region is an essential functional determinant that is required for binding to the RRE and for correct intracellular routing. Data obtained using a protein kinase CK2 phosphorylation assay indicated that the loop region is essential for juxtaposition of helices 1 and 2 and phosphorylation by protein kinase CK2. Deletion of the loop resulted in partial accumulation of Rev in SC35-positive nuclear bodies that resembled nuclear bodies that form in response to inhibition of transcription. Accumulation of the DeltaLoop mutant in nuclear bodies depended on the presence of an intact NES, suggesting that both the loop and the NES play a role in controlling intranuclear compartmentalization of Rev and its association with splicing factors.
Thymosin beta 4 (T beta 4) in activated platelets. (1993)

When resting human blood platelets are stimulated with thrombin, 50 to 60% of the G-actin polymerizes to F-actin within 60 seconds. The increase in F-actin is correlated with a corresponding decrease in the complex of G-actin with T beta 4. Within 5 seconds after stimulation, nucleation sites for pyrene actin polymerization increase 1.5 times in Triton-lysed supernatants. Cytochalasin D, known to inhibit the increase in F-actin after thrombin, also inhibits the fall in T beta 4-actin complex and the increase in nucleation sites. Phosphorylation of T beta 4 could not be detected in either control or activated cells. Increased T beta 4 corresponding to that lost from the T beta 4-actin complex is present in lysates from activated platelets and retains the ability to complex with actin. The data, taken together with previous estimates for the dissociation constant of the T beta 4-actin complex, show that actin polymerization following platelet activation could be controlled primarily by the increased availability of free barbed ends of actin filaments which have a higher affinity for G-actin than does T beta 4 and suggest that the increased free T beta 4 may serve to limit the degree of polymerization.
Genomics of the group of organisms (2005)

Members of the Bacillus cereus group of organisms include Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis. Collectively, these organisms represent microbes of high economic, medical and biodefense importance. Given this significance, this group contains the highest number of closely related fully sequenced genomes, giving the unique opportunity for thorough comparative genomic analyses. Much of the disease and host specificity of members of this group can be attributed to their plasmids, which vary in size and number. Chromosomes exhibit a high level of synteny and protein similarity, with limited differences in gene content, questioning the speciation of the group members. Genomic data have spurred functional studies that combined microarrays and proteomics. Recent advances are reviewed in this article and highlight the advantages of genomic approaches to the study of this important group of bacteria.
Extension of the Clinicoradiologic Spectrum of Newly Described End-Truncating LAMB1 Variations (2023)

The association of an extensive leukoencephalopathy with an episodic memory dysfunction of the hippocampal type is strongly suggestive of a <i>LAMB1</i> end-truncating variation in adults older than 50 years. Early cognitive complaints and imaging abnormalities might exist decades before. Additional transient manifestations can be observed, and this association should lead to <i>LAMB1</i> screening to avoid unnecessary invasive investigations.
EXTRAÇÃO DE CONTORNO DE TELHADOS DE EDIFICAÇÕES UTILIZANDO DADOS LASER E IMAGENS AÉREAS (2014)

RESUMO -As tecnologias atuais para obteno de dados geogrficos esto cada vez mais precisas e possibilitam a captura de informaes de uma grande rea territorial em pouco tempo como, por exemplo, a varredura a laser. Outra tecnologia que j utilizada h algum tempo a imagem digital de alta resoluo. Nesse contexto, a extrao de feies a partir desses dados tem recebido, nos ltimos anos, considervel ateno. Com a combinao de tipos diferentes de dados, possvel melhorar os resultados obtidos a partir da extrao de objetos em cenas complexas e, por esse motivo, este trabalho desenvolveu uma ferramenta a fim de automatizar a extrao do contorno dos telhados.
Compression volume during mechanical ventilation (1985)

Four ventilators (Puritan-Bennett MA-1 and MA-2, Emerson, and Bear I) and four commercially available disposable and nondisposable tubing circuits (Bennett nondisposable, Becton-Dickinson, Inspiron, and Life-line) were tested on a lung analog for differences in inspiratory-circuit compression volume. The compression ratio (Rc), equal to the gas volume compressed per cm H2O peak airway pressure, was calculated for each combination of ventilator and circuit at each of four compliance settings (0.15, 0.10, 0.05, 0.01 L/cm H2O) on the analog. Rc values ranged from 0.3 to 4.5 ml/cm H2O at the highest and lowest compliance settings, respectively, accounting for a reduction in delivered tidal volume of up to 20%. The Emerson ventilator with all tubing systems and the Bennett nondisposable circuit with each ventilator demonstrated slightly smaller compression volumes. Application of an inspiratory pause on the Bear I ventilator did not affect its compression characteristics. The clinical importance of compression volume and data from other ventilation systems are reviewed.
Simultaneous Multiline Emission Absorption Measurements in Optically Thick Turbulent Flames (1991)

Abstract Simultaneous transient emission/absorption measurements at five wavelengths in strongly radiating, optically thick, turbulent diffusion flames burning acetylene in air were completed. The data were processed to obtain CO2, mole fractions, temperatures and soot volume fractions spatially resolved to the estimated local integral length scale of mixture fraction fluctuations. Temperatures and soot volume fractions based on emission intensities showed strong negative correlation due to radiative cooling effects. Probability density functions of soot volume fractions conditioned on CO2, mole fractions showed similarities with position. However, probable effects of negligible diffusivity of soot particles were observed. Probability density functions of soot volume fractions conditioned on both CO2, concentrations and temperature illustrate the important role of radiative heal transfer in determining the flame structure. A multivariate stochastic analysis resulted in good predictions of radiation intensities.
Metal Nanoparticle Metamaterials For Engineering Dielectric Constants And Their Applications To Near Resonant Surface Plasmon Waveguides (2007)

We analyze metal nanoparticle metamaterials, allowing engineered negative or positive permittivity. Dissipative losses of bulk materials and near-resonant waveguides are treated and figures of merit formulated, quantifying necessary improvements in optical losses for various applications.
Plasma levels of oxytocin increase in response to suckling and feeding in dogs and sows (1985)

The objective of the present study was to investigate whether oxytocin is released in response to feeding in analogy to the response induced by suckling. Therefore, repeated plasma samples were drawn from dogs and pigs during feeding and suckling and oxytocin levels were determined by radioimmunoassay. As expected suckling gave rise to immediate and short-lasting increases of oxytocin levels in both species. More surprisingly, feeding in female and male dogs as well as in lactating sows was accompanied by a similar-sized rise of oxytocin levels. The oxytocin peak sometimes occurred before the actual period of suckling or feeding, suggesting that the output of oxytocin had been conditioned to visual, olfactory or auditory stimuli associated with both types of situations. It is well known that oxytocin is released in lactating animals in response to touching of the teats. It is possible that also the presence of food in the gastro-intestinal tract activates neurogenic mechanisms which stimulates the release of oxytocin. Since oxytocin causes a release of insulin and VIP (vasoactive intestinal polypeptide), peptides which appear in the circulation following both suckling and feeding, it is suggested that oxytocin may be involved in the control of the suckling- and feeding-related output of these peptides.
STUDIES ON THE STABILITIES AND ALLIED PROPERTIES OF ORGANIC COOLANTS (1965)

The suitability of either pure orthoterphenyl, metaterphenyl, paraterphenyl or mixtures of these as reactor coolants in a power reactor has been under investigation for some time. The thermal and radiation stabilities of Santowax-R and Santowax–OM1 to gamma-rays and reactor radiations have already been examined. The thermal stabilities of pure o-terphenyl and m-terphenyl as well as the results of some of the experiments carried out to study the influence of added substances to Santowax-OM1 on its stability to reactor radiations are presented in this report. Since Santowax-R and Santowax-OM1 have high melting points, they have to be kept heated in order to store them as liquids. To avoid this, experiments were carried out to find a coolant mixture which would be a liquid at room temperature. The results of these efforts are also reported here. The solubilities of hydrogen, nitrogen and methane in Santowax-OM1 at several temperatures up to 350 deg C have been determined. A method for the determination of viscosity of Santowax up to 200 deg C has been standardised. Several polyphenyls required for the identification of the high boiling fractions obtained during the radiolysis of terphenyls have been synthesised. (auth)
Immersion-cooled heat sinks for electronics: insight from high-speed photography (2001)

The development of effective heat sinks for the primary heat-dissipating component of a typical portable electronics device is an ongoing challenge. Thermal management using air-cooling is limited by the inherently limited thermal properties of the coolant. Other alternatives, including liquid immersion cooling, phase-change materials, and heat pipes, may merit consideration if the basic mechanisms can be reliably predicted. This study sheds light on the nucleation characteristics of an etched cavity-enhanced surface for use in an immersion-cooled heat sink. The target application is a high-density multichip module with several heat dissipating sources. High-speed photography was used to record parameters such as bubble interactions, bubble size, departure frequency and active site density while varying the cavity spacing and heat flux. The cavities, which have a characteristic dimension of approximately 40 /spl mu/m, are arranged in a square cluster 12.7 mm on each side. It was determined that the contribution of latent heat as a heat dissipation mechanism is only minor (less than 16%). In addition, it is proposed that the latent heat dissipation percentage may be used as a thermal performance indicator. Interactions between neighboring heat sources were also studied. These interactions decreased the bubble departure frequency and thereby affected the latent heat contribution.
Functionalization of the meso‐Phenyl Ring of Rhodamine Dyes Through SNAr with Sulfur Nucleophiles: Synthesis, Biophysical Characterizations, and Comprehensive NMR Analysis (Eur. J. Org. Chem. 2/2015) (2015)

The cover picture shows the interplay of diffusing light at dusk over the see. In contrast, the doughnut-shaped laser light used for stimulated emission depletion (STED) fluorescence nanoscopy is well spatially localized; it may be represented as a doughnut with a zero intensity point in the very center. The fluorescence of the molecules exposed to STED light (“covered” by the doughnut) is efficiently inhibited, and the area in which the molecules can fluoresce may be “squeezed” to a spot with dimensions that are no longer limited by diffraction. The structures, synthesis and properties of the rather photostable fluorophores are discussed in the article by G. Yu. Mitronova, V. N. Belov, M. John, S. W. Hell et al. on 337 ff. An additional functional group in the meso-phenyl ring attached to the xanthene fluorophore is a key feature of all rhodamine dyes discussed in this report. NMR studies and calculations established the positions of the substituents in the polysubstituted phenyl ring. The authors are grateful to Mr. H. Sebesse (MPI BPC) for his help in creating the cover picture.
Digital PWM control: application in voltage regulation modules (2003)

Conventionally, controllers for DC/DC converters have relied on analog circuit techniques for implementation. While analog based systems have proven successful, several reasons make digital control attractive. Digital control allows for the implementation of more functional control schemes. Digital circuits are potentially less susceptible to noise and parameter variations. With the explosion of cheap computing power, and availability of advanced integrated circuit design and synthesis tools, a digital controller design can be ported to new integrated circuit technology generations with little additional effort. Current trends in microprocessor designs lead toward decreasing supply voltages and increasing current demands. Future microprocessors are projected to require between 30-60 Amps of static current and impose di/dt requirements on the power supply in the order of 5 A/ns. In this paper, we focus on the design of a digital controller for an interleaved DC/DC buck converter to supply power for microprocessor loads. Digital logic makes the generation of identical, but delayed, gate drive signals for the various phases of the interleaved converter simple.
HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models (2008)

A better understanding of the propensity of individual HIV protease inhibitors to produce insulin resistance will allow the tailoring of individual treatment plans based upon overall risk for diabetes. The elucidation of the molecular mechanisms for alterations in glucose homeostasis will facilitate the development of newer generations of HIV protease inhibitors that maintain their clinical efficacy without contributing to the development of diabetes mellitus and other proatherogenic effects.
Acute Cardiac Tolerance of Current Contrast Media and the New Taxane Protaxel Using Iopromide as Carrier During Porcine Coronary Angiography and Stenting (2002)

The novel iso-osmolar nonionic CM iosmin is well tolerated in porcine coronary angiography and subsequent stenting. The cardiac tolerance of iopromide has not been adversely affected by addition of the cytostatic protaxel.
Surgical treatment of atypical aortic coarctation associated with occlusion of all arch vessels in Takayasu's disease (2002)

We report a patient with Takayasu's disease surgically treated who had presented severe manifestation due to aortic coarctation associated with occlusion of all arch branches. This patient had suffered cardiac failure and recurrent fainting attacks before surgery. The operative procedures included ascending to infra-renal aortic bypass grafting combined with reconstruction of the right axillary artery. Cardio-pulmonary bypass (CPB) was used to facilitate the proximal aortic anastomosis. Regional oxygen saturation in the bilateral frontal lobes was measured intraoperatively using near-infrared spectroscopy to detect cerebral ischemia. Regional oxygen saturation was managed above the critical level throughout the CPB. No new cerebral complications occurred in the perioperative period.
System Complexity and System Failures (2008)

Summary form only given. System complexity is a challenge both with regard to defining and agreeing on basic concepts of system dependability, and to actually achieving such dependability in practice from large computer-based systems. In this talk the author discusses such issues, and give a brief description of some recent work on a new approach to formally modelling and analysing the activity of complex (un)dependable systems. The author ends by discussing some likely dependability and security consequences of the overall complexity and chosen architecture of the huge National Programme for IT (NPflT) that is currently being undertaken by the National Health System in England, and which is claimed to be the world's largest civil IT project.
Submilliamp threshold 1.3 µm strained MQWlasers with novel p -substrateburied-heterostructure grown by MOVPE using TBA and TBP (1995)

An extremely low 0.4 mA threshold current has been achieved for novel current-blocking 1.3 µm strained MQW laser diodes. These devices are grown by MOVPE using tertiarybutylarsine (TBA) and tertiarybutylphosphine (TBP) precursors. The lowest threshold currents of 0.4 and 3.0 mA were obtained at 20 and 85°C, respectively, for a 150 µm-long 95%/98%-coated device.
Silicide und Germanide der Alkalimetalle (1948)

Abstract Durch direkte Synthese werden die Silicide NaSi, KSi, RbSi und CsSi, sowie die Germanide NaGe, KGe, RbGe und CsGe erhalten. Bei der thermischen Zersetzung im Hochvakuum entstehen Si‐ bzw. Ge‐reiche Verbindungen, vermutlich der Zusammensetzung KSi 8 , RbSi 8 , CsSi 8 sowie KGe 4 , RbGe 4 und CsGe 4 . Die Einordnung der erhaltenen Verbindungen wird besprochen.
The development of stranger fear in infancy and toddlerhood: normative development, individual differences, antecedents, and outcomes (2013)

Despite implications that stranger fear is an important aspect of developing behavioral inhibition, a known risk factor for anxiety, normative and atypical developmental trajectories of stranger fear across infancy and toddlerhood remain understudied. We used a large, longitudinal data set (N = 1285) including multi-trait, multi-method assessments of temperament to examine the normative course of development for stranger fear and to explore the possibility that individual differences exist in trajectories of stranger fear development between 6 and 36 months of age. A latent class growth analysis suggested four different trajectories of stranger fear during this period. Stable, high levels of stranger fear over time were associated with poorer RSA suppression at 6 months of age. Rates of concordance in trajectory-based class membership for identical (monozygotic) and fraternal (dizygotic) twins, along with associations between atypical stranger fear development and greater anxiety-related maternal characteristics, suggested that individual differences in developmental trajectories of stranger fear may be heritable. Importantly, trajectories of stranger fear during infancy and toddlerhood were linked to individual differences in behavioral inhibition, with chronically high levels of stranger fear and sharp increases in stranger fear over time related to greater levels of inhibition than other developmental trajectories.
Alternating Current Impedance Characterization of the Structure of Alkylsiloxane Self-Assembled Monolayers on Silicon (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlternating Current Impedance Characterization of the Structure of Alkylsiloxane Self-Assembled Monolayers on SiliconZ. H. Jin, D. V. Vezenov, Y. W. Lee, J. E. Zull, C. N. Sukenik, and R. F. SavinellCite this: Langmuir 1994, 10, 8, 2662–2671Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/la00020a027https://doi.org/10.1021/la00020a027research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts