gebhart/patrepeval huggingface dataset:
Broadband transition between waveguide and substrate integrated waveguide based on quasi-Yagi antenna (2012)

A novel broadband waveguide-to-substrate integrated waveguide transition is presented. The broadband transition is realised by using an antipodal quasi-Yagi antenna probe inserted into a rectangular metal waveguide. The transition is simulated and measured at 8–18GHz. The measured results show that good agreement with simulation and an insertion loss less than 2.7dB and a return loss better than 10dB are obtained at 9.5–17.5 GHz for a back-to-back structure.
ArtPlanner: Robust Legged Robot Navigation in the Field (2023)

Due to the highly complex environment present during the DARPA Subterranean Challenge, all six funded teams relied on legged robots as part of their robotic team. Their unique locomotion skills of being able to step over obstacles require special consideration for navigation planning. In this work, we present and examine ArtPlanner, the navigation planner used by team CERBERUS during the Finals. It is based on a sampling-based method that determines valid poses with a reachability abstraction and uses learned foothold scores to restrict areas considered safe for stepping. The resulting planning graph is assigned learned motion costs by a neural network trained in simulation to minimize traversal time and limit the risk of failure. Our method<sup>1</sup> achieves real-time performance with a bounded computation time. We present extensive experimental results gathered during the Finals event of the DARPA Subterranean Challenge, where this method contributed to team CERBERUS winning the competition. It powered navigation of four ANYmal quadrupeds for 90 minutes of autonomous operation without a single planning or locomotion failure.
Re: Is Primary Realignment Appropriate for the Initial Management of Straddle Injuries to the Bulbar Urethra? (2020)

No AccessJournal of UrologyUrological Survey1 Sep 2020Re: Is Primary Realignment Appropriate for the Initial Management of Straddle Injuries to the Bulbar Urethra? Sean P. ElliottMD Sean P. ElliottSean P. Elliott More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001172AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Is Primary Realignment Appropriate for the Initial Management of Straddle Injuries to the Bulbar Urethra?." The Journal of Urology, 204(3), p. 610 References 1. : Primary realignment vs suprapubic cystostomy for the management of pelvic fracture-associated urethral injuries: a systematic review and meta-analysis. Urology 2014; 83: 924. Google Scholar 2. : Updated outcomes of early endoscopic realignment for pelvic fracture urethral injuries at a level 1 trauma center. Urology 2018; 112: 191. Google Scholar 3. : Primary endoscopic realignment of urethral disruption injuries—a double-edged sword?J Urol 2015; 194: 1022. Link, Google Scholar © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 204Issue 3September 2020Page: 610-610 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sean P. Elliott More articles by this author Expand All Advertisement PDF downloadLoading ...
Therapeutic Expression of an Anti-Death Receptor 5 Single-Chain Fixed-Variable Region Prevents Tumor Growth in Mice (2006)

The clinical use of the single-chain fixed-variable (scFv) fragments of recombinant monoclonal antibodies as credible alternatives for classic therapeutic antibodies has two limitations: rapid blood clearance and inefficient local expression of functional molecules. In attempt to address these issues, we have developed a novel gene therapy protocol in which the anti-death receptor 5 (DR5) scFv fragments were either in vitro expressed in several tumor cell lines, or in vivo expressed in mice, using recombinant adeno-associated virus (rAAV)-mediated gene transfer. Viral transduction using the rAAV-S3C construct, which encodes a scFv molecule (S3C scFv) specific to DR5, led to stable expression in tumor cell lines and showed apoptosis-inducing activity in vitro, which could be inhibited by recombinant DR5 but not by DR4. A single i.m. injection of rAAV-S3C virus in nude mice resulted in stable expression of DR5-binding S3C scFv proteins in mouse sera for at least 240 days. Moreover, the expression of S3C scFv was associated with significant suppression of tumor growth and the increase of tumor cell apoptosis in previously established s.c. human lung LTEP-sml and liver Hep3B tumor xenografts.
40 Gb/s Silicon optical modulators (2011)

In this work we describe two 40Gb/s modulators that have been developed as part of the “UK Silicon Photonics project”, and the European “HELIOS” project. The modulators exploit the carrier depletion effect in MZI configurations.
Occurrence of the diffuse amyloid ?-protein (A?) deposits with numerous A?-containing glial cells in the cerebral cortex of patients with Alzheimer's disease (1999)

Diffuse amyloid beta-protein (Abeta) deposits with numerous glial cells containing C-terminal Abeta fragments occur in the cerebral cortex of patients with Alzheimer's disease. By using a panel of antibodies specific for various epitopes in the Abeta peptide, we have investigated the immunohistochemical nature of the diffuse Abeta deposits. The extracellular material contains Abeta with a C-terminus at residue valine40 (Abeta40) as well as residues alanine42/threonine43 (Abeta42). The N-termini include aspartate1, pyroglutamate3, and pyroglutamate11, with pyroglutamate3 being dominant. Microglia and astrocytes in and around these deposits contain intensely staining granules. Most of these granules are negative for antibodies to the N-terminally located sequences of Abeta. These include 6E10 (Abeta1-17), 6F/3D (Abeta8-17), and the N-terminal antibodies specific to aspartate1, pyroglutamate3, and pyroglutamate11. The C-termini of intraglial Abeta are comparable with those of the extracellular deposits. The microglia and astrocytes have quiescent morphology compared with those associated with senile plaques and other lesions such as ischemia. Complement activation in these deposits is not prominent and often below the sensitivity of immunohistochemical detection. Although factors which may cause this type of deposit remain unclear, lack of strong tissue responses suggests that these deposits are a very early stage of Abeta deposition. They were found only inconsistently and were absent in a number of cases examined in this study. Further analysis of these deposits might provide important clues regarding the accumulation and clearance of Abeta in Alzheimer's disease brain.
Daratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease (2023)

Primary effusion lymphoma (PEL), an aggressive non-Hodgkin lymphoma caused by Kaposi sarcoma-associated herpesvirus (KSHV), lacks standard therapy and has a median survival of 10-22 months with combination chemotherapy. PEL is a tumor of plasmablast-like B cells generally expressing CD38, the target of daratumumab (Dara). Initially, we assessed PEL cells from eight patients and established that each expressed high levels of CD38 by flow cytometry. PEL cell lines were also evaluated and most had high CD38 expression. We then assessed Dara's effects on complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) of PEL cell lines as well as its clinical benefits on two patients with PEL. Despite high CD38 expression, Dara did not induce CDC of PEL cell lines, due in part to high levels of the complement-inhibitory proteins, CD55 and CD59. However, Dara induced significant and dose-dependent increases in ADCC, particularly in those lines with high CD38 levels. Two FDA-approved drugs, all trans-retinoic acid (ATRA) and pomalidomide (Pom), significantly increased surface CD38 levels in low-CD38 expressing PEL cell lines, resulting in increased Dara-induced ADCC. Two patients with refractory PEL were treated with Dara alone or in combination with Pom. One patient with leptomeningeal PEL had a complete response to Dara and Pom combination treatment. Others had improvement in performance status and resolution of malignant ascites with Dara alone. Together, these data support the use of Dara monotherapy or in combination with ATRA or Pom as a potential therapeutic option for PEL.
Reevaluation of Growth Hormone Deficiency During and After Growth Hormone (GH) Treatment: Diagnostic Value of GH Tests and IGF-I and IGFBP-3 Measurements (2004)

Retesting of patients with growth hormone (GH) deficiency (GHD), especially those with idiopathic GHD, has yielded normalization of the results in several studies. The aim of this study was to reevaluate patients diagnosed as GHD at completion or reconfirm the diagnosis before completion of GH treatment by retesting with provocative tests, and to evaluate the value of IGF-I and IGFBP-3 levels in the diagnosis of GHD. Fifty (33 M, 17 F) patients with GHD (peak GH level <0.46 pmol/l (10 ng/ml]) in two pharmacological tests were retested and IGF-I and IGFBP-3 levels measured. The age of the patients at retest was 15.2+/-5.0 yr. Thirteen of 50 patients (26%) normalized their GH secretion. According to the initial diagnosis, 69% of those with partial GHD (peak GH level 0.32-0.46 pmol/l [7-10 ng/ml]), 43% with isolated GHD, 33% idiopathic and 11% of those with complete GHD (peak GH level <0.32 pmol/l [7 ng/ml]) normalized their GH level at retesting. None of the patients with multiple hormone deficiency and none with small pituitary on MRI normalized GH levels at retest. The sensitivities of IGF-I and of IGFBP-3 were 70% and 67%, respectively, and the specificities were 100%, when peak GH cutoff is taken as 0.46 pmol/l (10 ng/ml) for the diagnosis of GHD. The sensitivities of IGF-I and IGFBP-3 increased to 76.5% and 73.5% when the cutoff level for GHD is taken as 0.32 pmol/l (7 ng/ml). Those patients who normalized their GH levels at retest showed a satisfactory height velocity when GH therapy was discontinued. In conclusion, reevaluation of GH status may also be undertaken while patients are still on treatment as well as at completion of treatment, especially in patients with idiopathic, partial and isolated GHD, by retesting and by IGF-I and IGFBP-3 measurements. Lowering the cutoff level of GH peak at pharmacological tests to 0.32 pmol/l (7 ng/ml) will lower the number of false positive results in the diagnosis of GHD.
3. Immunology of leprosy (1993)

The host immune response to Mycobacterium leprae is critical for control of the infection but also responsible for the immunopathological damage to skin and nerves. The complex and varied immune responses to the organism are the basis for the clinical spectrum of disease ranging from tuberculoid to lepromatous leprosy. The cellular interactions underlying this spectrum are discussed and the antigenic components of the bacillus briefly reviewed. M. leprae has evolved a variety of mechanisms to avoid macrophage bactericidal mechanisms. These result in the persistence of bacilli and the release of cytokines leading to chronic granulomatous inflammation. The immune response to M. leprae is dynamic and spontaneous variations in cellular reactivity occur with time leading to type I and II leprosy reactions. The factors which preset the host immune response to a tuberculoid or lepromatous pattern and which precipitate reactional episodes remain to be elucidated.
Overload Control in Smart Transformer-Fed Grid (2017)

Renewable energy resources and new loads—such as electric vehicles—challenge grid management. Among several scenarios, the smart transformer represents a solution for simultaneously managing low- and medium-voltage grids, providing ancillary services to the distribution grid. However, unlike conventional transformers, the smart transformer has a very limited overload capability, because the junction temperature—which must always be below its maximum limit—is characterized by a short time constant. In this work, an overload control for smart transformer by means of voltage and frequency variations has been proposed and veriﬁed by means of simulations and experiments.
Epitaxial growth of YBa2Cu3O7−x thin films on (110) SrTiO3 single crystals by activated reactive evaporation (1988)

The orientation of YBa2Cu3O7−x thin films grown on (110) planes of SrTiO3 by activated reactive evaporation was investigated by means of reflection high-energy electron diffraction. The orientation of the films depended on the substrate temperature. The films with (110) planes parallel to the substrate surface grew in a narrow range of substrate temperatures around 530 °C, while the films with (103) planes parallel to the surface grew at temperatures above 600 °C. The change of the epitaxial orientation with the substrate temperature is discussed in terms of the temperature dependence of the lattice mismatch between YBa2Cu3O7−x and SrTiO3.
Accelerating run-time reconfiguration on FCCMs (2003)

The paper describes the implementation of the arithmetic operations of multiplication, division and square root on a Xilinx XC6200 FPGA. By using a design approach to enhance similarities across circuits, partial reconfiguration has been used to allow reductions in reconfiguration times of up to 75% on trials using the VCC HOTWorks board.
Home spirometry in patients with idiopathic pulmonary fibrosis: data from the INMARK trial (2021)

Home spirometry was a feasible and valid measure of lung function in patients with IPF and preserved FVC, but estimates of the rate of FVC decline obtained using home spirometry were poorly correlated with those based on clinic spirometry.
mGluRs induce a long‐term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors (2005)

Excitatory glutamatergic synapses on dopamine (DA) neurons of the ventral tegmental area (VTA) undergo long-lasting changes during conditioning of natural rewards and in response to drug exposure. It has been suggested that the ensuing context-dependent behavioural changes are associated with an increased efficacy of synaptic afferents determined by the balance of long-term potentiation (LTP) and long-term depression (LTD). However, the molecular nature of the forms of LTP/LTD involved remains elusive. Here, using acute rat brain slices, we describe a form of long-term depression (LTD) that was engaged by synaptic activity or exogenous agonists activating group I metabotropic glutamate receptors (mGluR) and was sensitive to mGluR1 antagonists. Prior to mGluR-LTD, AMPAR mediated excitatory postsynaptic currents (EPSCs) showed strong rectification at positive potentials and were sensitive to Joro spider toxin (JST), a selective blocker of GluR2-lacking AMPARs. After mGluR-LTD, AMPAR EPSCs had linear current-voltage relations and became insensitive to JST. We conclude that activation of mGluR1s triggers a redistribution exchanging native receptors for GluR2 containing AMPARs, ultimately causing LTD that may oppose pathological neuroadaptation.
Diagnostic efficacy of Ziehl-Neelsen method against fluorescent microscopy in detection of acid fast bacilli (2010)

Objective:To investigate the application of Ziehl-Neelsen(Z-N) and fluorescent microscopy in detection of acid fast bacilli(AFB).Methods:Duplicate smears were prepared from 260 sputum samples and stained with Z-N and fluorescent staining(FS) methods.The efficiency of both methods in primary diagnosis of tuberculosis were evaluated.Results:The smears were positive for AFB in 15(5.77%) samples by Z-N staining method and in 16(6.15%) samples by FS method.The sensitivity and specificity of Z-N staining method against FS method were 93.75% and 100%respectively.Conclusions:Though lesser cost-effective than Z-N,FS method is a more sensitive and better case finding tool in detection of AFB.
Sodium Ions at Defect Sites at SiO2/Si Interfaces as Determined by X-Ray Photoelectron Spectroscopy (1975)

X-ray photoelectron spectroscopy (XPS) is described in its application as a probe for studying defects such as sodium in SiO2 films. A general description is given of key experimental methods in XPS. New techniques are described for applying and monitoring a fixed bias at the surface of the oxide during the XPS measurement. These methods are shown capable of detecting extremely small Na and Cu concentrations in undoped samples (< 1011 cm-2). In deliberately Na-doped samples, five spectral peaks are distinctly observed and related to different defect states at the vacuum/SiO2 and SiO2/Si interfaces. By applying a bias-temperature stress during the XPS measurements, these peaks change in relative intensity and can be related to the motion of the Na+ ions between different states occurring at the two interfaces. An attempt is made to correlate the observations with previously reported models.
The sigma E subunit of Bacillus subtilis RNA polymerase is present in both forespore and mother cell compartments (1989)

Bacillus subtilis cells harvested 3.5 h after the onset of sporulation (t3.5) were fractionated into extracts enriched in either mother cell or forespore components and were analyzed immunologically for sigma E and its precursor protein, P31. We determined by Western blot (immunoblot) analysis that equivalent amounts of P31 and sigma E were present in both mother cell and forespore extracts. This result implies that, although sigma E is not synthesized until a stage in development when the cell is partitioned into progenitor forespore and mother cell compartments, it probably directs the transcription of genes that are expressed in both of these structures.
Operational Ranges for Suction Lysimeters (1985)

Abstract Four questions relative to suction lysimeter performance have been raised by operators of land treatment systems. These questions deal with plugging of the porous segments of the lysimeters, soil suction operational ranges, adsorption onto and screening by the materials comprising the various lysimeter parts, and loss of volatile organics under negative pressures. This article first describes the physical operation of a lysimeter, the characteristics of the lysimeters tested (high‐ and low‐flow lysimeters with porous ceramic cups and lysimeters with porous PTFE (polytetrafluo‐roethylene) cups, and procedures followed in preparing them for testing. The results of experiments dealing with the first two questions plugging and operational ranges are then discussed. It was found that the intake rate of suction lysimeters placed in the vadose zone, in most types of soils, will initially drop off rapidly, but will stabilize after about 15 liters of moisture have been drawn through the porous cups. Packing a crystalline silica flour slurry around the cups of PTFE lysimeters negates most of the plugging associated with finer particles in soils. The effective operating range of ceramic lysimeters is between 0 and 60 centibars of suction independent of the use of silica flour. The operating range of PTFE lysimeters without silica flour is extremely narrow, but with the use of silica flour is extended to about 7 centibars of suction. The testing program indicates that all lysimeters should be checked for leaks using pressure techniques before field installation and that lysimeters have “dead” spaces, or reservoirs of from 34 to 80 mL of moisture that cannot be extracted from the cups, which must be taken into account when determining moisture collection rates. Information gathered in the test program is planned for inclusion in an EPA guidance document entitled “Unsaturated Zone Monitoring at Hazardous Waste Land Treatment Units.”
Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial (2020)

Our aim was to assess the efficacy and safety of intravenous (i.v.) paracetamol vs. i.v. ibuprofen for the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. This is a multicenter randomized controlled study. Infants with a gestational age of 25<sup>+0</sup>-31<sup>+6</sup> weeks were randomized to receive i.v. paracetamol (15 mg/kg/6 h for 3 days) or i.v. ibuprofen (10-5-5 mg/kg/day). The primary outcome was the closure rate of hsPDA after the first treatment course with paracetamol or ibuprofen. Secondary outcomes included the constriction rate of hsPDA, the re-opening rate, and the need for surgical closure. Fifty-two and 49 infants received paracetamol or ibuprofen, respectively. Paracetamol was less effective in closing hsPDA than ibuprofen (52 vs. 78%; P = 0.026), but the constriction rate of the ductus was similar (81 vs. 90%; P = 0.202), as confirmed by logistic regression analysis. The re-opening rate, the need for surgical closure, and the occurrence of adverse effects were also similar.Conclusions: Intravenous paracetamol was less effective in closing hsPDA than ibuprofen, but due to a similar constriction effect, its use was associated with the same hsPDA outcome. These results can support the use of i.v. paracetamol as a first-choice drug for the treatment of hsPDA.Trial registration: Clinicaltrials.gov : NCT02422966, Date of registration: 04/09/2015; EudraCT no: 2013-003883-30. What is Known: • The successful closure of patent ductus arteriosus with oral paracetamol has been recently reported in several preterm infants, but only one randomized controlled study investigated the efficacy of intravenous paracetamol. What is New: • Intravenous paracetamol is less effective in closing hsPDA than ibuprofen, but have a similar constriction effect. • These results can support the use of i.v. paracetamol as a first-choice drug for the treatment of hsPDA.
Interstellar ices: a possible scenario for symmetry breaking of extraterrestrial chiral organic molecules of prebiotic interest (2018)

International audience
Characterization of the [18.28]0−–a3Δ1 (0,0) band of tantalum nitride, TaN (2017)

The [18.28]0<sup>-</sup>-a<sup>3</sup>Δ<sub>1</sub> (0,0) band near 647 nm of tantalum nitride, TaN, has been recorded and analyzed field-free and in the presence of static electric and magnetic fields. The fine and hyperfine parameters for the a<sup>3</sup>Δ<sub>1</sub> and [18.28]0<sup>-</sup> states are determined. The <sup>181</sup>Ta(I = 7/2) axial nuclear electric quadrupole coupling constant, eQq<sub>0</sub>, and the effective magnetic hyperfine coupling constant, h<sub>1</sub>, are used to garner insight into the nature of electronic states. The Stark tuning of the P(2) and Q(1) lines was analyzed to determine the molecular frame permanent electric dipole moment, μ→<sub>el</sub>, for the a<sup>3</sup>Δ<sub>1</sub> state of 4.49 ± 0.09 D. The Zeeman effect on the P(1) line was analyzed to determine an upper limit of the magnetic moment, μ→<sub>m</sub>, for the a<sup>3</sup>Δ<sub>1</sub> state. Scalar-relativistic coupled-cluster calculations for eQq<sub>0</sub> and μ→<sub>el</sub> of the a<sup>3</sup>Δ<sub>1</sub> state are also reported and compared with experimental results. The determined properties are compared with the predicted values and the implication of the proposed scheme for determination of the <sup>181</sup>Ta magnetic quadrupole moment is discussed.