gebhart/patrepeval huggingface dataset:
Global performance enhancements via pedestal optimisation on ASDEX Upgrade (2016)

Results of experimental scans of heating power, plasma shape, and nitrogen content are presented, with a focus on global performance and pedestal alteration. In detailed scans at low triangularity, it is shown that the increase in stored energy due to nitrogen seeding stems from the pedestal. It is also shown that the confinement increase is driven through the temperature pedestal at the three heating power levels studied. In a triangularity scan, an orthogonal effect of shaping and seeding is observed, where increased plasma triangularity increases the pedestal density, while impurity seeding (carbon and nitrogen) increases the pedestal temperature in addition to this effect. Modelling of these effects was also undertaken, with interpretive and predictive models being employed. The interpretive analysis shows a general agreement of the experimental pedestals in separate power, shaping, and seeding scans with peeling-ballooning theory. Predictive analysis was used to isolate the individual effects, showing that the trends of additional heating power and increased triangularity can be recoverd. However, a simple change of the effective charge in the plasma cannot explain the observed levels of confinement improvement in the present models.
Copper‐Catalyzed Reaction of Trifluoromethylketones with Aldehydes via a Copper Difluoroenolate (2015)

A copper-catalyzed reaction of easily accessible α,α,α-trifluoromethylketones with various aldehydes affords difluoro-methylene compounds in the presence of diboron and NaOtBu. The key process of the reaction is the formation of a copper difluoroenolate by 1,2-addition of a borylcopper intermediate to α,α,α-trifluoromethylketones and subsequent β-fluoride elimination. Mechanistic studies including the isolation and characterization of a possible anionic copper alkoxide intermediate are also described.
[Effect of long-term physical training on hemostasis in patients with coronary heart disease and non-insulin dependent diabetes]. (2004)

In patients with combination of coronary heart disease and NIDDM long-term physical training was associated with decreased thrombogenicity of blood.
Multimedia System for Emergency Services over TETRA-DVBT Networks (2008)

This paper describes the main challenges of implementing a multimedia on demand system (TetraMoD) for emergency scenarios. The objective of this system is to offer a complete solution for providing multimedia services (video on demand and reliability file transfer) to a rescue team in an emergency situation. This multimedia system will improve the traditional emergency communications. We propose to integrate the use of different networks, TETRA and DVBT, characterized by a wide geographical coverage and broadband broadcast, respectively. This system consists of the following elements: a TetraMoD gateway - the unit deployed on as interface between TETRA and DVBT networks- and a middleware TetraMoD client -the software for the client terminal. A real scenario and example of communication using standard protocols (SDP, RTP/RTCP, RTSP, FLUTE) are showed.
FREE AMINO ACID LEVELS IN THE CEREBROSPINAL FLUID OF NORMAL HUMANS AND THEIR VARIATION IN CASES OF EPILEPSY AND SPIELMEYER‐VOGT‐BATTEN DISEASE (1974)

Abstract— The concentrations of free amino acids in the plasma and cerebrospinal fluid from control subjects and from patients suffering from epilepsy and Spielmeyer‐Vogt‐Batten disease were determined using an automatic amino acid analyser. It was found that the plasma/cerebrospinal fluid ratio of amino acid concentrations showed the variation in the amounts of free amino acids in epilepsy more clearly than the cerebrospinal fluid levels alone.
3,4,5-Trimethoxybenzohydrazidium chloride (2008)

The title compound, C(10)H(15)N(2)O(4) (+)·Cl(-), was obtained as an unexpected by-product during the synthesis of 1-[2-(substituted ar-yl)]-3-methyl-pyrazol-5-ones. The hydrazide group is essentially planar, with an r.s.m. deviation of 0.020 (2) Å, and is oriented at a dihedral angle of 30.52 (3)° with respect to the benzene ring. In the crystal structure, the cations and anions are linked through N-H⋯O and N-H⋯Cl hydrogen bonds, forming a mol-ecular tape running along the b axis.
Integrin receptor specificity for human red cell ICAM‐4 ligand (2004)

The red cell intercellular adhesion molecule‐4 (ICAM‐4) binds to different members of the integrin receptor families. To better define the ICAM‐4 integrin receptor specificity, cell transfectants individually expressing various integrins were used to demonstrate that α L β 2 , α M β 2 , and α IIb β 3 (activated) bind specifically and dose dependently to the recombinant ICAM‐4‐Fc protein. We also show that cell surface ICAM‐4 interacts with the cell surface α V β 3 integrin. In addition, using a α 4 β 1 cell transfectant and β 2 integrin‐deficient LAD cells, we show here that ICAM‐4 failed to interact with α 4 β 1 even after α 4 β 1 activation by phorbol ester or with the monoclonal antibody TS2/16 (+ Mn 2+ ). ICAM‐4 amino acids that are critical for α IIb β 3 and α V β 3 interaction were identified by domain deletion analysis, site‐directed mutagenesis and synthetic peptide inhibition. Our results provide evidence that the β 3 integrin binding sites encompass the first and second Ig‐like domains of ICAM‐4. However, while the α IIb β 3 contact site comprises the ABED face of domain D1 with an extension in the C′‐E loop of domain D2, the α V β 3 contact site comprises residues on both faces of D1 and in the C′‐E loop of D2. These data, together with our previous results, demonstrate that different integrins bind to different but partly overlapping sites on ICAM‐4, and that ICAM‐4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells.
Characterization of Hard Diamond-Like Carbon Films Formed by Ar Gas Cluster Ion Beam-Assisted Fullerene Deposition (2002)

The coordination of carbon atoms in diamond-like carbon (DLC) thin films formed by Ar gas cluster ion beam (GCIB) assisted deposition using fullerene as the carbon source was investigated by measuring near-edge X-ray absorption fine structure (NEXAFS) spectra of the carbon K-edge over the excitation energy range 275–320 eV, using synchrotron radiation. With attention to the peak corresponding to the transition of the excitation electron from a carbon 1s orbital to a π* orbital, relative sp2 contents of various DLC films were estimated. The sp2 contents of the DLC films formed by the GCIB-assisted deposition were observed to be lower than those of the DLC films formed by other methods. The hardness value measured with a nano-indentation technique was found to be strongly related to the sp2 content of the DLC film.
Distributed Quality of Service Based Provisioning Framework for Survivable Optical Networks (2011)

This chapter provides new distributed frameworks to support Quality of Service (QoS) differentiation. These frameworks provide differentiated protection services to meet customers’ availability requirements effectively. We describe the availability-analysis for connections with different protection schemes. Through this analysis, we show how connection availability is affected by resource sharing. Based on the availability analysis, the proposed framework provisions each connection in which an appropriate level of protection is provided according to its predefined availability requirement. We consider the networks without wavelength conversion capability as well as dynamic traffic environment. In these distributed frameworks we propose several distributed schemes to provision and manage connections cost-effectively while satisfying the existing and new connections availability requirements.
Production Strategies for Pentamer-Positive Subviral Dense Bodies as a Safe Human Cytomegalovirus Vaccine (2019)

Infections with the human cytomegalovirus (HCMV) are associated with severe clinical manifestations in children following prenatal transmission and after viral reactivation in immunosuppressed individuals. The development of an HCMV vaccine has long been requested but there is still no licensed product available. Subviral dense bodies (DB) are immunogenic in pre-clinical models and are thus a promising HCMV vaccine candidate. Recently, we established a virus based on the laboratory strain Towne that synthesizes large numbers of DB containing the pentameric protein complex gH/gL/UL128-131 (Towne-UL130repΔGFP). The work presented here focuses on providing strategies for the production of a safe vaccine based on that strain. A GMP-compliant protocol for DB production was established. Furthermore, the DB producer strain Towne-UL130rep was attenuated by deleting the UL25 open reading frame. Additional genetic modifications aim to abrogate its capacity to replicate in vivo by conditionally expressing pUL51 using the Shield-1/FKBP destabilization system. We further show that the terminase inhibitor letermovir can be used to reduce infectious virus contamination of a DB vaccine by more than two orders of magnitude. Taken together, strategies are provided here that allow for the production of a safe and immunogenic DB vaccine for clinical testing.
Phosphorylation of Y14 Modulates Its Interaction with Proteins Involved in mRNA Metabolism and Influences Its Methylation (2005)

The multicomponent exon junction complex (EJC) is deposited on the spliced mRNA during pre-mRNA splicing and is implicated in several post-splicing events, including mRNA export, nonsense-mediated mRNA decay (NMD), and translation control. This report is the first to identify potential post-translational modifications of the EJC core component Y14. We demonstrate that Y14 is phosphorylated at its repeated arginine/serine (RS) dipeptides, likely by SR protein-specific kinases. Phosphorylation of Y14 abolished its interaction with EJC components as well as factors that function downstream of the EJC. A non-phosphorylatable Y14 mutant was equivalent to the wild-type protein with respect to its association with spliced mRNA and its ability in NMD activation, but the mutant sequestered EJC and NMD factors on ribosome-containing mRNA ribonucleoproteins (mRNPs). We therefore hypothesize that phosphorylation of Y14 occurs upon completion of mRNA surveillance, leading to dissociation of Y14 from ribosome-containing mRNPs. Moreover, we found that Y14 is possibly methylated at multiple arginine residues in the carboxyl-terminal domain and that methylation of Y14 was antagonized by phosphorylation of RS dipeptides. This study reveals antagonistic post-translational modifications of Y14 that may be involved in the remodeling of Y14-containing mRNPs.
Evaluation of an outside-the-Cold-Chain Vaccine Delivery Strategy in Remote Regions of Western China (2009)

Very often in this high-tech age of data transmission and elaborate analytical and clinical tools we can sometimes lose sight of the fact that there are some very basic elements of public health that still need improvement.A wonderful example is the cold-chain vaccine delivery strategy assessment carried out by Ren et al.Maintaining a "cold chain" for vaccines is a significant challenge to any immunization program-especially one in a developing county-and other articles have shown similar challenges and results. 1,2 Nowhere is this more of a challenge than in the remote areas of western China.The authors point out that in many places in remote China, the residents often live great distances from any health-care center or facility.A logical and practical approach to maintaining the "cold chain" is to operate the immunization program in the cold months of winter; however, this approach does not control for the extreme cold temperatures, which also pose a challenge to health-care workers.This article provides practical insight into the challenges facing the health-care workers.It demonstrates that training, even in the most basic areas, is necessary to improve vaccine handling, and that the extreme cold, which at first glance appears should provide less of a problem, still shows a decrease in the efficacy of the vaccines exposed to lower temperatures.Practical and inexpensive methods and containers need to be developed to maintain a constant and desirable temperature.As developing countries wrestle with improving their vaccination rates, they also need to be aware of the challenges associated with ineffective vaccines that are no longer potent.
What’s New in Capillary Rheometry? (1998)

Traditionally, the linear flow behavior of polymer melts at low shear rates has been characterized with rotational rheometers, while the non-linear shear thinning region at high shear rates is measured with capillary rheometers.
Microfabrication of microsystem-enabled photovoltaic (MEPV) cells (2011)

Microsystem-Enabled Photovoltaic (MEPV) cells allow solar PV systems to take advantage of scaling benefits that occur as solar cells are reduced in size. We have developed MEPV cells that are 5 to 20 microns thick and down to 250 microns across. We have developed and demonstrated crystalline silicon (c-Si) cells with solar conversion efficiencies of 14.9%, and gallium arsenide (GaAs) cells with a conversion efficiency of 11.36%. In pursuing this work, we have identified over twenty scaling benefits that reduce PV system cost, improve performance, or allow new functionality. To create these cells, we have combined microfabrication techniques from various microsystem technologies. We have focused our development efforts on creating a process flow that uses standard equipment and standard wafer thicknesses, allows all high-temperature processing to be performed prior to release, and allows the remaining post-release wafer to be reprocessed and reused. The c-Si cell junctions are created using a backside point-contact PV cell process. The GaAs cells have an epitaxially grown junction. Despite the horizontal junction, these cells also are backside contacted. We provide recent developments and details for all steps of the process including junction creation, surface passivation, metallization, and release.
Work in Progress: Micro-skills and Mini-habits in Engineering Student Teams: Facilitating a Confluence of Perspectives and Talent (2018)

She teaches classes on strategic relationships for industrial distribution and distribution logistics
Effect of aggregation behavior and phenolic hydroxyl group content on the performance of lignosulfonate doped PEDOT as a hole extraction layer in polymer solar cells (2015)

Aggregation behaviour and –OH content of lignosulfonate play a key role for the promising performance when PEDOT:LS acts as the HEL in PSCs.
Hyaluronidase allergy after peribulbar anesthesia with orbital inflammation (2004)

A 70-year-old woman previously exposed to hyaluronidase during ophthalmic surgery had excision of hypertrophic bulbar conjunctival tissue in the right eye. Hyaluronidase was added to the peribulbar anesthetic agent. Five days postoperatively, the patient presented with proptosis in the right eye, extraocular muscle restriction, and decreased visual acuity. She was apyrexial with a normal white cell count; computed tomography of the orbits showed a diffuse increase in soft tissue density. Clinical features were unchanged after 24 hours of intravenous antibiotics, but subsequent administration of high-dose oral steroids led to clinical improvement.
Bounded Quantifier Instantiation for Checking Inductive Invariants (2019)

We consider the problem of checking whether a proposed invariant $\varphi$ expressed in first-order logic with quantifier alternation is inductive, i.e. preserved by a piece of code. While the problem is undecidable, modern SMT solvers can sometimes solve it automatically. However, they employ powerful quantifier instantiation methods that may diverge, especially when $\varphi$ is not preserved. A notable difficulty arises due to counterexamples of infinite size. This paper studies Bounded-Horizon instantiation, a natural method for guaranteeing the termination of SMT solvers. The method bounds the depth of terms used in the quantifier instantiation process. We show that this method is surprisingly powerful for checking quantified invariants in uninterpreted domains. Furthermore, by producing partial models it can help the user diagnose the case when $\varphi$ is not inductive, especially when the underlying reason is the existence of infinite counterexamples. Our main technical result is that Bounded-Horizon is at least as powerful as instrumentation, which is a manual method to guarantee convergence of the solver by modifying the program so that it admits a purely universal invariant. We show that with a bound of 1 we can simulate a natural class of instrumentations, without the need to modify the code and in a fully automatic way. We also report on a prototype implementation on top of Z3, which we used to verify several examples by Bounded-Horizon of bound 1.
Low-power digital filtering using approximate processing (1996)

We present an algorithmic approach to the design of low-power frequency-selective digital filters based on the concepts of adaptive filtering and approximate processing. The proposed approach uses a feedback mechanism in conjunction with well-known implementation structures for finite impulse response (FIR) and infinite impulse response (IIR) digital filters. Our algorithm is designed to reduce the total switched capacitance by dynamically varying the filter order based on signal statistics. A factor of 10 reduction in power consumption over fixed-order filters is demonstrated for the filtering of speech signals.
Preparation of Pyrrolidine‐Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α‐Substituted Malonates to Aromatic Nitroalkenes. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Optimal unified IIR architectures for time-recursive discrete sinusoidal transforms (1993)

An optimal unified architecture that can efficiently compute the discrete cosine, sine, Hartley, Fourier, lapped orthogonal, and complex lapped transforms for a continuous input data stream is proposed. This structure uses only half as many multipliers as the previous best known scheme. The proposed architecture is regular, modular, and locally connected. In the realisation of the discrete cosine transform, only 2N-2 multipliers are needed. A theoretical justification is provided showing that any discrete transform whose basic functions satisfy the fundamental recurrence formula has a second-order autoregressive structure in its filter realization. It is also demonstrated that dual generation transform pairs share the same autoregressive structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
NEUROLOGICAL FEATURES IN CHILDREN AND DIPHENYLARSINIC ACID PROBABLY DERIVED FROM CHEMICAL WARFARE AGENTS (2006)

Objectives: Diphenylarsinic acid (DPAA), an artificial organoarsinic compounds, is a material of diphenylcyanoarsine or diphenylchloroarsine, to use as emetic type chemical warfare agents. We found DPAA intoxication by oral ingestion of ground water in Kamisu, Japan. We reported that the characteristics of this intoxication for adults were homogeneous including cerebellar-brainstem symptoms such as ataxic gait and scanning speech, myoclonus, tremor, and sleep disorder, and cerebral symptoms such as visual impairment and memory impairment (Ishii K, et al., 2004). Here we report clinical features of children with oral ingestion of well water contained with DPAA.
On the Erd\H{o}s Covering Problem: the density of the uncovered set (2018)

Since their introduction by Erd\\H{o}s in 1950, covering systems (that is,\nfinite collections of arithmetic progressions that cover the integers) have\nbeen extensively studied, and numerous questions and conjectures have been\nposed regarding the existence of covering systems with various properties. In\nparticular, Erd\\H{o}s asked if the moduli can be distinct and all arbitrarily\nlarge, Erd\\H{o}s and Selfridge asked if the moduli can be distinct and all odd,\nand Schinzel conjectured that in any covering system there exists a pair of\nmoduli, one of which divides the other.\n Another beautiful conjecture, proposed by Erd\\H{o}s and Graham in 1980,\nstates that if the moduli are distinct elements of the interval $[n,Cn]$, and\n$n$ is sufficiently large, then the density of integers uncovered by the union\nis bounded below by a constant (depending only on $C$). This conjecture was\nconfirmed (in a strong form) by Filaseta, Ford, Konyagin, Pomerance and Yu in\n2007, who moreover asked whether the same conclusion holds if the moduli are\ndistinct and sufficiently large, and $\\sum_{i=1}^k \\frac{1}{d_i} &lt; C$. Although\nthis condition turns out not to be sufficiently strong to imply the desired\nconclusion, as the main result of this paper we will give an essentially best\npossible condition which is sufficient.\n Our method has a number of further applications. Most importantly, we prove\nthe conjecture of Schinzel stated above, which was made in 1967. We moreover\ngive an alternative (somewhat simpler) proof of a breakthrough result of Hough,\nwho resolved Erd\\H{o}s' minimum modulus problem, with an improved bound on the\nsmallest difference. Finally, we make further progress on the problem of\nErd\\H{o}s and Selfridge.\n
MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK- and B-cell counts (2013)

To the editor:

Several inherited bone marrow failure syndromes (IBMFSs) have been characterized, such as Fanconi anemia; however, about 1 in 4 IBMFS patients remain unclassified.[1][1],[2][2] Next-generation sequencing can be a powerful tool to identify novel genetic etiologies in patients with
Synthesis of Homoallyl Ethers via Allylation of Acetals and Aldehydes in Ionic Liquids (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Energy-constrained optimal quantization for wireless sensor networks.~~ (2005)

As low power, low cost and longevity of transceivers are major requirements in wireless sensor networks, optimizing their design under energy constraints is of paramount importance. To this end, we develop quantizers under strict energy constraints to effect optimal reconstruction at the fusion center. Propagation, modulation, as well as transmitter and receiver structures are jointly accounted for using a binary symmetric channel model. We first optimize quantization for reconstructing a single sensor's measurement. Optimal number of quantization levels and optimal energy allocation across bits are derived. We then consider multiple sensors collaborating to estimate a deterministic parameter in noise. Similarly, optimum energy allocation and optimum number of quantization bits are derived analytically and tested with simulated examples.
Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41 (2019)

Results suggest that T20 has a double-target mechanism, by which its N-terminal and C-terminal portions bind to N-terminal heptad repeat and FPPR, respectively. T20-SF designed based on this new mechanism exhibits significantly improved anti-HIV-1 activity because it targets the triple sites in gp41, including N-terminal heptad repeat, FPPR, and fusion peptide. Thus, this study provides clues for designing novel HIV fusion inhibitors with improved antiviral activity.