gebhart/patrepeval huggingface dataset:
RNA-BASED DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM TUBERCULOSIS (2018)

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Neovascularization Is Attenuated With Aldosterone Synthase Inhibition in Rats With Retinopathy (2012)

Neovascularization is a hallmark feature of retinopathy of prematurity and diabetic retinopathy. Type 1 angiotensin receptor blockade reduces neovascularization in experimental retinopathy of prematurity, known as oxygen-induced retinopathy (OIR). We investigated in OIR whether inhibiting aldosterone with the aldosterone synthase inhibitor FAD286 reduced neovascularization as effectively as angiotensin receptor blockade (valsartan). OIR was induced in neonatal Sprague-Dawley rats, and they were treated with FAD286 (30 mg/kg per day), valsartan (10 mg/kg per day), or FAD286+valsartan. The cellular sources of aldosterone synthase, the mineralocorticoid receptor, and 11β-hydroxysteroid dehydrogenase 2 were evaluated in retinal cells involved in neovascularization (primary endothelial cells, pericytes, microglia, ganglion cells, and glia). In OIR, FAD286 reduced neovascularization and neovascular tufts by 89% and 67%, respectively, and normalized the increase in vascular endothelial growth factor mRNA (1.74-fold) and protein (4.74-fold) and was as effective as valsartan and FAD286+valsartan. In retina, aldosterone synthase mRNA was reduced with FAD286 but not valsartan. Aldosterone synthase was detected in microglia, ganglion cells, and glia, whereas mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase 2 were present in all of the cell types studied. Given the location of aldosterone synthase in microglia and their contribution to retinal inflammation and neovascularization in OIR, the effects of FAD286 on microglial density were studied. The increase in microglial density (ionized calcium binding adaptor protein 1 immunolabeling) in OIR was reduced with all of the treatments. In OIR, FAD286 reduced the increase in mRNA for tumor necrosis factor-α, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and monocyte chemoattractant molecule 1. These findings indicate that aldosterone inhibition may be a potential treatment for retinal neovascularization.
Low temperature FDSOI devices, a key enabling technology for 3D sequential integration (2013)

Processing a high performance transistor at temperature lower than 650°C is the main challenge of 3D sequential integration. This paper shows how FDSOI architecture enables to overcome the issues observed in bulk devices, i.e: higher junction leakage and deactivation and allow performance matching of low temperature devices with their high temperature counterparts.
Parameterized block-based non-gaussian statistical gate timing analysis (2006)

As technology scales down, timing verification of digital integrated circuits becomes an increasingly challenging task due to the gate and wire variability. Therefore, statistical timing analysis (denoted by σTA) is becoming unavoidable. This paper introduces a new framework for performing statistical gate timing analysis for non-Gaussian sources of variation in block-based σTA. First, an approach is described to approximate a variational RC-π load by using a canonical first-order model. Next, an accurate variation-aware gate timing analysis based on statistical input transition, statistical gate timing library, and statistical RC-π load is presented. Finally, to achieve the aforementioned objective, a statistical effective capacitance calculation method is presented. Experimental results show an average error of 6% for gate delay and output transition time with respect to the Monte Carlo simulation with 104 samples while the runtime is nearly two orders of magnitude shorter.
Practical Experiments on Fabricated TAS-MRAM Dies to Evaluate the Stochastic Behavior of Voltage-Controlled TRNGs (2019)

Noises exist in digital circuits can be leveraged as the source of entropy to design true random numbers generators (TRNGs), which is an important primitive component in cryptography and hardware-based security applications. In this paper, we present practical experiments and results of a TRNG implemented on magnetic random-access memory (MRAM) dies, fabricated by the thermally-assisted-switching MRAM (TAS-MRAM) technology. We, first, explain how one can find out a heating voltage value using that writing operations in the TAS-MRAM dies have a stochastic behavior. Then, we propose an improvement based on a feedback loop from being generated random bits. It helps to adjust the founded heating voltage value for writing operation with the aim of reaching the maximum entropy. Finally, we report the results of some post-processing methods, which are usually required in TRNGs to successfully pass the statistical test of NIST SP-800. The results show that one can generate random numbers with a high quality of randomness using the proposed TRNGs besides simple post-processing methods.
Optical I/O Technology for Tera-Scale Computing (2010)

This paper describes both a near term and a long term optical interconnect solution, the first based on a packaging architecture and the second based on a monolithic photonic CMOS architecture. The packaging-based optical I/O architecture implemented with 90 nm CMOS transceiver circuits, 1 × 12 VCSEL/detector arrays and polymer waveguides achieves 10 Gb/s/channel at 11 pJ/b. A simple TX pre-emphasis technique enables a potential 18 Gb/s at 9.6 pJ/b link efficiency. Analysis predicts this architecture to reach less than 1 pJ/b at the 16 nm CMOS technology node. A photonic CMOS process enables higher bandwidth and lower energy-per-bit for chip-to-chip optical I/O through integration of electro-optical polymer based modulators, silicon nitride waveguides and polycrystalline germanium (Ge) detectors into a CMOS logic process. Experimental results for the photonic CMOS ring resonator modulators and Ge detectors demonstrate performance above 20 Gb/s and analysis predicts that photonic CMOS will eventually enable energy efficiency better than 0.3 pJ/b with 16 nm CMOS. Optical interconnect technologies such as these using multi-lane communication or wavelength division multiplexing have the potential to achieve TB/s interconnect and enable platforms suitable for the tera-scale computing era.
Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons (2021)

The mounting evidence for the involvement of astrocytes in neuronal circuits function and behavior stands in stark contrast to the lack of detailed anatomical description of these cells and the neurons in their domains. To fill this void, we imaged >30,000 astrocytes in hippocampi made transparent by CLARITY, and determined the elaborate structure, distribution, and neuronal content of astrocytic domains. First, we characterized the spatial distribution of >19,000 astrocytes across CA1 lamina, and analyzed the morphology of thousands of reconstructed domains. We then determined the excitatory somatic content of CA1 astrocytes, and measured the distance between inhibitory neuronal somata to the nearest astrocyte soma. We find that on average, there are almost 14 pyramidal neurons per domain in the CA1, increasing toward the pyramidal layer midline, compared to only five excitatory neurons per domain in the amygdala. Finally, we discovered that somatostatin neurons are found in close proximity to astrocytes, compared to parvalbumin and VIP inhibitory neurons. This work provides a comprehensive large-scale quantitative foundation for studying neuron-astrocyte interactions.
QoS aware routing for end-to-end reliability of delay sensitive events in wireless sensor networks (2009)

Most of the applications developed for wireless sensor networks demand the QoS aware routing protocol in order to deliver the high critical data more reliably with minimum number of message exchanges. This will lead to achieve significant energy conservation and low delivery latency under congested network conditions. In this paper, a novel Energy Reservation based QoS (ERes-QoS) aware routing protocol has been proposed. The ERes-QoS ensures end-to-end performance guarantee for high critical data on hop-by-hop basis in two domains: timeliness and reliability. An angle based router set is constructed at each node, to achieve on-time reachability of the data. For QoS provisioning in a reliability domain, we use local decision approach at each intermediate node, which exploits Multipaths, Energy Reservation and hop-by-hop unicasting with acknowledgement, without end-to-end path discovery and maintenance. The Proposed protocol provides a differentiated routing service by assigning priorities to data packets according to their criticality. This is done by reserving the required energy to relay the traffic at the routers along the dynamically explored path, and by employing packet classifier and multi-level queue priority scheduling modules at each intermediate node. As a result, the ERes-QoS achieves high data delivery ratio that meets both timeliness and reliability requirement. Simulation results demonstrate that, the ERes-QoS routing protocol provides significant improvements in data delivery latency, path establishment latency and data delivery ratio.
Spatial temporal adaptive direct mode coding on bidirectional motion compensation prediction (2004)

Abstract Although bidirectional motion compensation reduces the coding distortion of a predictive image and improves prediction efficiency, the information indicating the spatial and temporal position of the predictive image is overhead and consumes more bits. Consequently, the coding efficiency is not always improved. The direct mode is widely used to improve coding efficiency with small overhead since it calculates the motion vectors of bidirectional prediction using the time continuity of motion. Such an improvement in prediction efficiency, however, is not achieved when the time continuity of motion does not exist. Therefore, the efficiency is highly dependent on the contents of a sequence. In this paper, we propose a spatial temporal adaptive direct mode, which is efficient even when there is no time continuity of motion. In this method, the time continuity of motion is predicted from the coding states of spatially or temporally adjacent blocks, and either a temporal direct mode or a spatial prediction mode is chosen as the coding mode. The spatial prediction mode calculates the motion vectors and the prediction direction from the motion vectors of the spatially adjacent blocks. This paper discusses the problem of the conventional direct mode, and proposes its solution. The results of computer simulations prove that this solution method can select the appropriate coding mode adaptively for the contents of a sequence, thus achieving high coding efficiency. © 2004 Wiley Periodicals, Inc. Syst Comp Jpn, 35(14): 1–9, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/scj.20126
Type II Strain Layer Superlattices (SLS's) grown on GaAs Substrates (2007)

We report on type-II SLS's photodiodes grown on GaAs. The GaSb buffer was grown using a novel interfacial- misfit-approach, which relieves the strain though 90 misfit dislocations. The dark-current, quantum-efficiency and detectivity were measured.
Use of subgenomic poliovirus DNA hybridization probes to detect the major subgroups of enteroviruses (1984)

Three nucleic acid hybridization probes were derived from DNA clones of the poliovirus type 1 genome. Used in dot hybridization experiments, the probes successfully detected members of each of the major enteroviral subgroups. The hybridization patterns obtained with the three probes suggested that a highly conserved nucleotide sequence existed among the enteroviruses tested, mapping between bases 220 and 1809 in the poliovirus genome. Two new antiviral agents capable of inhibiting enterovirus replication in tissue culture were used to demonstrate the specificity of the probes for viral RNA.
Tumor Scintigraphy in Primary Lung Cancer using 67Ga-citrate (1977)

原発性肺癌247例の67Gaシンチグラム上, 陽性描画に影響を及ぼす因子とその限界について考察すると共に, 67Ga腫瘍集積機序についても検討した. 67Ga-citrateは腫瘍径4cm以上のものには高率に集積するが, 肺癌腫瘤の小さいものは集積が悪く, 早期診断や肺門リンパ節転移の検索には必ずしも有効ではなかった. ただ, 肺癌の進展状態の把握, 病態を知る上で有用であり, 放射線治療の効果の推定に役立つと考えられる結果を得た.
Iron Removal from Milk and Other Nutrient Media with a Chelating Resin (1995)

A water-insoluble iron(III)-chelating resin was used to study iron removal from milk and other nutrient media. Seventy to 85% of the iron could be removed from wine and beer with the resin, which was a crosslinked copolymer of 1-(beta-acrylamidoethyl)-3-hydroxy-2-methyl-4(1H)- pyridinone and N,N-dimethylacrylamide. Iron removal from milk was dependent on the pH of milk and on the concentration of soluble chelators added. Under the same conditions as used for the removal of iron from wine and beer, only 11 to 19% of the iron could be removed from milk. However, in combination with water-soluble chelators, the resin removed 60 to 75% of the iron from the milk. Preliminary results showed that the growth of spores of Clostridium tyrobutyricum in the treated milk was reduced. Moreover, addition of the resin and sodium bicarbonate to the milk completely inhibited the growth of the spores.
Bioproduction of 2-Phenylethanol in a Biphasic Ionic Liquid Aqueous System (2010)

2-Phenylethanol (PEA) is a commercial flavor and fragrance compound, with a rose-like odor, used in the cosmetics and food industries. Saccharomyces cerevisiae strains produce PEA in a growth-associated manner but are prone to product inhibition, resulting in low production yields. The aim of this study was to use immiscible ionic liquids (ILs) in a biphasic system to enhance the PEA concentration by means of in situ product removal (ISPR). Nine ILs were tested for their influence on growing yeast cells, and five of them were found to be biocompatible. A correlation between the IL structure and the effect on yeast growth was investigated. [Tf(2)N] anions were found to be the most biocompatible in comparison to [PF(6)] and [BF(4)], and the pyridinium and ammonium cations were slightly preferable than the imidazolium cation. Furthermore, the longer the alkyl side chain on the imidazolium ring, the less it is biocompatible, with major significance above six carbons. The five biocompatible ILs were tested for PEA recovery capability by determining their distribution coefficients (K(D)), with the highest value of 17.6 obtained for BMIM[Tf(2)N]. Finally, ILs were tested for their efficiency as ISPR solvents under stress conditions of a high product concentration. A 3-5-fold increase in the total PEA concentration produced by the cells was obtained with MPPyr[Tf(2)N], OMA[Tf(2)N], and BMIM[Tf(2)N], demonstrating the potential of ILs for enhancing productivity in bioprocesses using growing cells.
Implicit Apodization of Interferograms in Fourier Transform Spectroscopy (1983)

The removal of secondary and tertiary interferograms from the main interferogram in Fourier transform spectroscopy can lead to an implicit apodization of the specimen interferogram. This effect can result in the generation of unwanted artifacts in the specimen's transmittance or absorption spectrum. One approach for avoiding this problem is to use an apodization function on the background and reference interferograms which matches the function used on the specimen interferogram.
High Efficiency Energy Conversion Systems for Liquid Nitrogen Automobiles (1998)

&lt;div class="htmlview paragraph"&gt;This investigation of the use of cryogens as energy storage media for zero emission vehicles has found that using liquid nitrogen to liquefy the working fluids of one or more closed Rankine power cycles can be an effective means for increasing motive power. System configurations are presented which can realize over 50% of the availability of liquid nitrogen without relying on isothermal expanders. A zero emission vehicle utilizing such a propulsion system would have an energy storage reservoir that can be refilled in a matter of minutes and a range comparable to that of a conventional automobile.&lt;/div&gt;
Assessment of 65nm subthreshold logic for smart RFID applications (2009)

Nowadays, new ultra-low-power electronic applications require small digital circuits with an increasing number of functionalities and an always decreasing power budget, but compensated by a weak constraint on performances. RFID is such an example of application. In this context, this paper explores the efficiency of 65nm subthreshold logic in an AES coprocessor for smart RFID. The power consumption of such a circuit synthesized with a commercial 65nm library at nominal 1.2V Vdd is 1.14μW at 100kHz. As the huge timing slack suggests, the supply voltage can be lowered to reduce the power. A recharacterized library down to 0.4V enables the synthesis of the circuit, still working at 100 kHz (worst-case process and temperature) with a power consumption of 57.5nW. Furthermore, the usefulness of the recharacterized library for logic synthesis in the subthreshold regime is demonstrated.
Analysis and Purification of Synthetic Nucleic Acids Using HPLC (2000)

HPLC is a powerful and popular method for analyzing and purifying biomolecules. Reversed-phase HPLC allows a high-capacity method for purification, and uses volatile buffer systems that simplify product recovery. Anion-exchange HPLC provides better resolution and a more predictable elution pattern. This unit presents protocols that are optimized for HPLC of oligonucleotides. Because of the resolution limits of both reversed-phase and anion-exchange HPLC, it can be used for oligonucleotides of up to approximately 50 nt in length.
Computerized detection of nosocomial infections in newborns. (1994)

Hospital-acquired infections are responsible for an increase in patient mortality and costs. Their detection is essential to permit better infection control. We developed an expert system specifically to detect infections in pediatric patients. The expert system is implemented at LDS Hospital that has a level three newborn intensive care unit and well baby units. We describe how the knowledge base of the expert system was developed, implemented, and validated in a retrospective study. The results of the system were compared to manual reviewer results. The expert system had a sensitivity of 84.5% and specificity of 92.8% in detecting hospital-acquired infections when compared to a physician reviewer. The Cohen's kappa between the expert system and the physician reviewer was 0.62 (p < .001).
High power-durable RF-band SAW filters using single-crystalAl/Ti electrodes grown on 64°Y-X LiNbO 3 substrates (1998)

To improve the power-durability of RF-band SAW filters, single-crystal Al/Ti electrode films were successfully grown on 64°Y-X LiNbO3 substrates by the electron-beam vapour deposition technique. The time to failure of the single-crystal Al/Ti electrodes became approximately 680 times longer than that of Al-Cu alloy electrodes.
Platinum(II) trichlorostannate complexes with nitrogen ligands. Platinum-195, tin-119, phosphorus-31, and nitrogen-15 NMR studies and the x-ray crystallographic structure of (p-chloroaniline)(triethylphosphine)chloro(trichlorostannato)platinum(II) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlatinum(II) trichlorostannate complexes with nitrogen ligands. Platinum-195, tin-119, phosphorus-31, and nitrogen-15 NMR studies and the x-ray crystallographic structure of (p-chloroaniline)(triethylphosphine)chloro(trichlorostannato)platinum(II)A. Albinati, H. Moriyama, H. Rueegger, P. S. Pregosin, and A. TogniCite this: Inorg. Chem. 1985, 24, 25, 4430–4433Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/ic00219a049https://doi.org/10.1021/ic00219a049research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hydrogen recovery from industrial waste gas streams for fuel cell application (2020)

The need to promote the circular economy by upcycling the resources leads to a great relevance of hydrogen-containing waste gas streams recovery. Thus, the overall objective of this thesis is the contribution to the recovery of hydrogen from industrial waste gas mixtures by investigating two different separation technologies: polymeric membranes and pressure swing adsorption (PSA) processes, in order to obtain high-purity hydrogen. To achieve such general goal, the research has been centered in providing methodological issues to surplus hydrogen recovery; evaluating the performance of commercial hydrogen-selective polymeric membranes using multicomponent gas mixtures; and producing fuel cell grade hydrogen from an industrial waste gas stream via PSA process.
[The effectiveness of oral cyproterone acetate in combination with ethinylestradiol in acne tarda of the facial type]. (1999)

EE/CPA is an effective treatment for acne of all grades and all types of lesion. The preparation is well tolerated and would appear to be an appropriate treatment for women with these symptoms of androgenization.
Reactivation of latent herpes simplex virus from explanted dorsal root ganglia (1994)

Reactivation was induced by explantation of dorsal root ganglia (DRG) from mice that were latently infected with herpes simplex virus type 1. Reactivation was first detected, using combined in situ hybridization and immunocytochemistry, at 2 or 3 days post-explantation (p.e.). Evidence of reactivation was found primarily in neurons that did not also contain latency-associated transcripts (LATs). Occasionally, mRNA of immediate early gene 2 (IE2) or IE4/5, in the absence of other viral mRNAs or antigen, was found in LAT+ neurons. Thus, if reactivation was occurring in LAT+ neurons, the LATs must have been lost as an early consequence; however we could detect neither a decrease in the percentages of LAT+ neurons nor a reduction in the intensity of the LAT signal during the period of reactivation. However, the number of foci of reactivation was generally less than 2·9% of the estimated number of LAT+ cells in the DRG; this may account for our failure to see such changes. A redistribution of the LATs into the cytoplasm was found in some cells but this could reflect the poor survival and consequent death of the explanted neurons. We conclude that the majority of LAT+ neurons did not reactivate on explantation and that if reactivation occurred only in LAT+ neurons, the LATs must have been removed from the nucleus as an early consequence of reactivation. Alternatively, there may be a population of latently infected cells that do not express LATs.