gebhart/patrepeval huggingface dataset:
MS‐KIF18A, a kinesin, is associated with estrogen receptor (2006)

The study of MS-KIF18A kinesin protein is focused on its cellular distribution and association with a cargo protein. Indirect immunofluorescence (IF) analyzed the intracellular distribution of endogenous MS-KIF18A and the transfected enhanced green fluorescence protein (eGFP)-MS-KIF18A in osteogenic cells. In both cases, the proteins were localized at the plasma membrane, cytosol, and nucleus. Bioinformatics analysis suggested interactions between MS-KIF18A and estrogen receptor (ERalpha) which were further elucidated by immunoprecipitation (IP). We identified interaction between endogenous MS-KIF18A with 66 and 46 kDa isoforms of ERalpha in MBA-15 cells. Moreover, MS-KIF18A and 66 kDa ERalpha complex has been demonstrated between ectopically expressed proteins in COS-7 cells. We have shown that anti-MS-KIF18A antibody immunoprecipitated the ERalpha and pERK in cells challenged with 17beta-estrogen (17beta-E2). The hormone activation induced mitogen-activated protein kinases (MAPK) pathway and increased p-ERK. The activation was interfered when cells were pre-treated with either ICI-182,780 or MAPK inhibitor PD98059 prior the challenge with 17beta-E2 that resulted in a decrease in association between MS-KIF18A and p-ERK1/2. The obtained results suggest a role for the proteins in a non-genomic response of MBA-15 cells challenged with 17beta-E2. This study presents a novel interaction between MS-KIF18A and ER that may have important physiological and pharmacological implications for estrogen action in various cells.
Controlled Electrical Conductivity in SnO2 Thin Films by Oxygen or Hydrocarbon Assisted Atomic Layer Epitaxy (1999)

The conventional atomic layer epitaxy process for pure thin films uses and as precursors and as the carrier gas. By applying gas‐phase additives (n‐hexane, ozone) or using oxygen as a carrier gas, a reduced electrical conductivity of the solid was obtained. This phenomenon is associated with the modifications in the grain structure and/or in the point defect concentration. To verify this, structural studies by X‐ray diffraction, atomic force microscopy, Auger electron spectroscopy, and secondary ion mass spectroscopy were performed. The results suggest that the variations in electrical resistivity (0.1–89 Ω cm) are predominantly due to variations in the electronic carrier concentration, i.e., oxygen vacancy and/or chlorine‐impurity concentrations, which were induced by gas‐phase additives. The most promising additive was hexane, as it resulted in films of the lowest conductivity as well as the highest crystallinity and stoichiometry. The strength of this effect was, however, dependent on the position of hexane pulse in the pulsing sequence. © 1999 The Electrochemical Society. All rights reserved.
Epidemiologic and Economic Burden Attributable to First Spinal Fusion Surgery (2017)

4.
Atomic Spectroscopy: A Review (2010)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTAtomic Spectroscopy: A ReviewNicolas H. Bings*†, Annemie Bogaerts‡, and José A. C. Broekaert§View Author Information Inorganic and Analytical Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk-Antwerp, Belgium, and Inorganic and Applied Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany* To whom correspondence should be addressed. E-mail: [email protected]†Johannes Gutenberg-University Mainz.‡University of Antwerp.§University of Hamburg.Cite this: Anal. Chem. 2010, 82, 12, 4653–4681Publication Date (Web):May 13, 2010Publication History Published online13 May 2010Published inissue 15 June 2010https://pubs.acs.org/doi/10.1021/ac1010469https://doi.org/10.1021/ac1010469review-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views7700Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ablation,Elements,Ions,Isotopes,Plasma Get e-Alerts
Refractoriness of Prostatism to Hydroxyprogesterone Capponate (delalutin) Therapy (1968)

No AccessJournal of Urology1 Jul 1968Refractoriness of Prostatism to Hydroxyprogesterone Capponate (delalutin) Therapy Sidney R. Weinberg Sidney R. WeinbergSidney R. Weinberg More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62474-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Refractoriness of Prostatism to Hydroxyprogesterone Capponate (delalutin) Therapy." The Journal of Urology, 100(1), pp. 57–58 © 1968 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByWolf H (2018) The Significance of Histological Changes in Serial Prostatic Biopsy SpecimensJournal of Urology, VOL. 113, NO. 1, (75-81), Online publication date: 1-Jan-1975. Volume 100Issue 1July 1968Page: 57-58 Advertisement Copyright & Permissions© 1968 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Sidney R. Weinberg More articles by this author Expand All Advertisement Loading ...
Program optimization for instruction caches (1989)

This paper presents an optimization algorithm for reducing instruction cache misses. The algorithm uses profile information to reposition programs in memory so that a direct-mapped cache behaves much like an optimal cache with full associativity and full knowledge of the future. For best results, the cache should have a mechanism for excluding certain instructions designated by the compiler. This paper first presents a reduced form of the algorithm. This form is shown to produce an optimal miss rate for programs without conditionals and with a tree call graph, assuming basic blocks can be reordered at will. If conditionals are allowed, but there are no loops within conditionals, the algorithm does as well as an optimal cache for the worst case execution of the program consistent with the profile information. Next, the algorithm is extended with heuristics for general programs. The effectiveness of these heuristics are demonstrated with empirical results for a set of 10 programs for various cache sizes. The improvement depends on cache size. For a 512 word cache, miss rates for a direct-mapped instruction cache are halved. For an 8K word cache, miss rates fall by over 75%. Over a wide range of cache sizes the algorithm is as effective as increasing the cache size by a factor of 3 times. For 512 words, the algorithm generates only 32% more misses than an optimal cache. Optimized programs on a direct-mapped cache have lower miss rates than unoptimized programs on set-associative caches of the same size.
ChemInform Abstract: Synthesis and Characterization of a New Spinel, Li1.02Al0.25Mn1.75O3.97 S0.03, Operating at Potentials Between 4.3 and 2.4 V. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
X-Ray Diffraction data from RSV-Neutralizing Human Antibody AM14, source of 4ZYK structure (2015)

Native dataset
alignancy in pediatric transplant recipients (2006)

Malignancy is a well defined complication of chronic immunosuppression. Post transplant malignancies appear to be related to cumulative doses of immunosuppression, and in pediatric patients, acute infection of previously naive patients. The most commonly encountered malignancy in this age population is Post Transplant Lymphoproliferative Disorder (PTLD). PTLD is not a single entity but rather represents a continuum of disease. Treatment of PTLD should be initiated with immunosuppression reduction. Standard dose chemotherapy leads to significant morbidity. With the introduction of anti-CD20 antibody treatment with rituximab, chemotherapy has become second line therapy. The occurrence of solid malignancy appears to be associated with chronic immunosuppression. These cancers include those of skin, gynecologic organs, and the rectum, all of which appear to have the strongest association with viral mediators. Several strategies have been postulated to minimize the occurrence of malignancy. These include ganciclovir prophylaxis for the prevention of PTLD and the use of mychophenolic acid and TOR inhibitor maintenance to diminish the incidence of PTLD and solid malignancies. This leaves transplant physicians with several new and novel immunosuppressive agents with uncertain oncologic potentials that will need to be examined over the next decade. © 2006 Elsevier Inc. All rights reserved. INDEX WORDS Pediatric solid organ transplantation; Chronic immunosuppression; Malignancy in transplant recipients; Lymphoproliferative disorder; Epstein–Barr virus; Viral inducement
Identification and characterization of a human corticosteroid binding globulin variant with a reduced affinity for cortisol (1985)

A corticosteroid binding globulin variant (CBGv) has been identified in a serum sample taken from an apparently healthy woman during late pregnancy. Identification was based on the observation that it exhibited approximately half the cortisol binding capacity expected when compared to its concentration measured by radioimmunoassay (RIA). Affinity purification of CBGv excluded the possibility that this anomaly was caused by assay interference, and demonstrated that immunoreactive CBGv was capable of binding cortisol. The CBGv had a molecular weight (63 800) similar to normal CBG, and no evidence of molecular aggregation was found by gel filtration. Although the electrophoretic mobility, isoelectric profile and immunochemical identity of CBGv appeared to be similar to normal CBG, it focussed as two distinct bands (pI 5.48 and pI 5.53) after desialylation with neuraminidase, unlike normal CBG which focuses only at pI 5.48. Investigation of the steroid binding characteristics of CBGv revealed a reduced association-rate constant (Ka = 1.05 X 10(9) l/mol) and dissociation half-time (12.5 min) when compared with normal CBG (Ka = 1.39 X 10(9) l/mol and 25 min at 0 degree C) but an apparently normal steroid binding specificity. Although the physiological significance of this variant is not known, the cortisol concentration in the variant serum was within the normal range of women during late pregnancy. No other CBG variants were identified among other normal controls (n = 66) or nine patients with Cushing's syndrome. It is suggested that comparisons between cortisol binding capacity and RIA will reveal other variants of CBG, and lead to greater understanding of their physiological significance.
Large eddy simulation for jet noise: the importance of getting the boundary layer right (2015)

Large eddy simulations of an isothermal Mach 0.9 jet issued from a convergent-straight nozzle are performed at Reynolds number 1 × 10 6 .The flow configuration and operating conditions match the companion experiment conducted at the PPRIME Institute, Poitiers.To replicate the effects of the boundary layer trip present in the experiment and to ensure a turbulent jet, localized adaptive mesh refinement, synthetic turbulence, and wall modeling are used inside the nozzle.This leads to fully turbulent nozzle-exit boundary layers and results in significant improvements for the flow field and sound predictions, compared to those obtained from the typical approach based on laminar flow assumption in the nozzle.The far-field noise spectra now match the experimental measurements to within 0.5 dB for relevant angles and frequencies.As a next step toward better understanding of turbulent jet noise, the large database collected during the simulation is currently being used for reduced order modeling and wavepacket analysis.
Detection and prevention of firewall-rule conflicts on software-defined networking (2015)

Software-Defined Networking (SDN) is a different approach to manage a network by software. It could use well-defined software expressions and predicates to regulate network behavior. Current SDN controllers, such as Floodlight, offer a framework to develop, test and run applications that control the network operation, including the firewall function. However, they are not able to validate firewall policies, detect conflicts; neither avoids contradictory configurations on network devices. Some compilers only detect conflicts by a subset of the language; hence, it cannot detect conflicts related to contradicting rules with security controls. This paper presents our framework based on Alloy called FireWell. FireWell is able to model firewall policies as formal predicates to validate, detect and prevent conflicts in firewall policies. In addition we present the implementation of FireWell and test it using the Floodlight controller and firewall application.
Error Probability Bounds for Balanced Binary Relay Trees (2012)

We study the detection error probability associated with a balanced binary relay tree, where the leaves of the tree correspond to <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> identical and independent sensors. The root of the tree represents a fusion center that makes the overall detection decision. Each of the other nodes in the tree is a relay node that combines two binary messages to form a single output binary message. Only the leaves are sensors. In this way, the information from the sensors is aggregated into the fusion center via the relay nodes. In this context, we describe the evolution of the Type I and Type II error probabilities of the binary data as it propagates from the leaves toward the root. Tight upper and lower bounds for the total error probability at the fusion center as functions of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> are derived. These characterize how fast the total error probability converges to 0 with respect to <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> , even if the individual sensors have error probabilities that converge to 1/2.
Cerebral Water Content in Silicone Oil-Induced Hydrocephalic Rabbits (1987)

Specific gravity determinations were made on fresh and desiccated samples of hydrocephalic rabbit brains. There was a density gradient in the normal cortical gray matter. Hydrocephalus was accompanied by significantly increased specific gravity of cortical gray matter at 3 days and 1 and 4 weeks. In the latter two periods, there were also significant increases in the specific gravity of white matter in the corpus callosum. These changes represent water loss throughout the whole cerebrum except at the ventricular surface. The specific gravity of solid tissue brain components changed insignificantly. We conclude that short-term brain volume changes in experimental hydrocephalus were due mainly to loss of tissue water.
Combined stochastic and set-membership information filtering in multisensor systems (2012)

In state estimation theory, stochastic and set-membership approaches are generally considered separately from each other. Both concepts have distinct advantages and disadvantages making each one inherently better suited to model different sources of estimation uncertainty. In order to better utilize the potentials of both concepts, the core element of this paper is a Kalman filtering scheme that allows for a simultaneous treatment of stochastic and set-membership uncertainties. An uncertain quantity is herein modeled by a set of Gaussian densities. Since many modern applications operate in networked systems that may consist of a multitude of local processing units and sensor nodes, estimates have to be computed in a distributed manner and measurements may arrive at high frequency. An algebraic reformulation of the Kalman filter, the information filter, significantly eases the implementation of such distributed fusion architectures. This paper explicates how stochastic and set-membership uncertainties can simultaneously be treated within this information form and compared to the Kalman filter, it becomes apparent that the quality of some required approximations is enhanced.
Synthesis of dissipative nonlinear controllers for series resonant DC/DC converters (1999)

This paper describes analytical advances and practical experiences in a nonlinear controller design methodology for series resonant DC/DC converters. The control goal is to maintain the output voltage (which is the only measured variable) in the presence of large-load perturbations by varying the switching frequency. The proposed methodology utilizes large-scale, nonlinear switched, and generalized averaged models, and the resulting closed-loop system is exponentially convergent under typical operating conditions. The designer has a direct handle over the convergence rate, and the nonlinear controller requires only the usual output voltage measurements, while the load variations are estimated. The control structure allows for variations in both resistive and current loads. The dissipativity-based nonlinear controller is implemented in affordable analog circuitry and evaluated experimentally.
Update to “Homologous Recombination Repair Defect May Predict Treatment Response to Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors” (2022)

This letter to the editor reports subsequent rechallenge with peptide receptor radionuclide therapy (PRRT) in a patient with pancreatic neuroendocrine tumor bearing BRCA1 mutation previously treated with PRRT.
Dispersion-Uncompensated Transmission of NRZ and PAM-4 Single-Sideband Signals using D-EML (2018)

International audience
Surface charge of gold nanoparticles mediates mechanism of toxicity (2011)

Recently gold nanoparticles (Au NPs) have shown promising biological and military applications due to their unique electronic and optical properties. However, little is known about their biocompatibility in the event that they come into contact with a biological system. In the present study, we have investigated whether modulating the surface charge of 1.5 nm Au NPs induced changes in cellular morphology, mitochondrial function, mitochondrial membrane potential (MMP), intracellular calcium levels, DNA damage-related gene expression, and of p53 and caspase-3 expression levels after exposure in a human keratinocyte cell line (HaCaT). The evaluation of three different Au NPs (positively charged, neutral, and negatively charged) showed that cell morphology was disrupted by all three NPs and that they demonstrated a dose-dependent toxicity; the charged Au NPs displayed toxicity as low as 10 µg ml(-1) and the neutral at 25 µg ml(-1). Furthermore, there was significant mitochondrial stress (decreases in MMP and intracellular Ca2+ levels) following exposure to the charged Au NPs, but not the neutral Au NPs. In addition to the differences observed in the MMP and Ca2+ levels, up or down regulation of DNA damage related gene expression suggested a differential cell death mechanism based on whether or not the Au NPs were charged or neutral. Additionally, increased nuclear localization of p53 and caspase-3 expression was observed in cells exposed to the charged Au NPs, while the neutral Au NPs caused an increase in both nuclear and cytoplasmic p53 expression. In conclusion, these results indicate that surface charge is a major determinant of how Au NPs impact cellular processes, with the charged NPs inducing cell death through apoptosis and neutral NPs leading to necrosis.
Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas (2015)

To elucidate mechanisms underlying epidemiological findings of decreased risk of glioma development in patients with allergies and asthma, gliomas were induced in mice deficient for histidine decarboxylase (HDC), the enzyme responsible for histamine production. These mice exhibited shortened survival and enhanced tumor growth compared to wild-type (WT) mice. Previous studies have shown a pivotal role of HDC in maturation of bone marrow (BM)-derived myeloid cells. In our glioma models, brain-infiltrating leukocytes (BIL) demonstrated an increased frequency of CD11b<sup>+</sup>Gr1<sup>+</sup> immature myeloid cells (IMC; both CD11b<sup>+</sup>Ly6G<sup>+</sup> and CD11b<sup>+</sup>Ly6C<sup>+</sup> subpopulations) as well as diminished CD8<sup>+</sup> T cell infiltration and their effector functions in HDC<sup>-/-</sup> mice compared with WT mice. Furthermore, HDC<sup>-/-</sup> IMC demonstrated a more profound immune suppression of CD8<sup>+</sup> T cell proliferation and functions associated with increased prostaglandin E2 (PGE2) expression levels. Celecoxib, a cyclooxygenase-2 inhibitor, which is vital for PGE2 production, abrogated suppressive capabilities of HDC<sup>-/-</sup> IMC. In addition, glioma-bearing HDC-eGFP mice, in which HDC promoter drives green fluorescence protein (GFP) expression, exhibited decreased HDC promoter activities in CD11b<sup>+</sup>Gr1<sup>+</sup> cells in the BM, spleen, and intracranial tumor site compared with non-tumor bearing HDC-eGFP mice. Additionally, <i>in vitro</i> culture with glioma supernatants decreased GFP expression in CD11b<sup>+</sup>Gr1<sup>+</sup>, CD11b<sup>+</sup>Ly6G<sup>+</sup>, and CD11b<sup>+</sup>Ly6C<sup>+</sup> IMC. HDC expression levels inversely correlated with suppressive functions of CD11b<sup>+</sup>Gr1<sup>+</sup> IMC, as GFP<sup>-</sup>CD11b<sup>+</sup>Gr1<sup>+</sup> more profoundly inhibited CD8<sup>+</sup> T cell proliferation compared with CD11b<sup>+</sup>Gr1<sup>+</sup>GFP<sup>+</sup> cells. Taken together, these data show a significant role of HDC in the glioma microenvironment via maturation of myeloid cells and resulting activation of CD8<sup>+</sup> T cells.