gebhart/patrepeval huggingface dataset:
Metabolomics reveals that aldose reductase activity due to AKR1B10 is upregulated in hepatitis C virus infection (2014)

To understand the changes in the metabolome of hepatitis C virus (HCV)-infected persons, we conducted a metabolomic investigation in both plasma and urine of 30 HCV-positive individuals using plasmas from 30 HCV-negative blood donors and urines from 30 healthy volunteers. Samples were analysed by gas chromatography-mass spectrometry and data subjected to multivariate analysis. The plasma metabolomic phenotype of HCV-positive persons was found to have elevated glucose, mannose and oleamide, together with depressed plasma lactate. The urinary metabolomic phenotype of HCV-positive persons comprised reduced excretion of fructose and galactose combined with elevated urinary excretion of 6-deoxygalactose (fucose) and the polyols sorbitol, galactitol and xylitol. HCV-infected persons had elevated galactitol/galactose and sorbitol/glucose urinary ratios, which were highly correlated. These observations pointed to enhanced aldose reductase activity, and this was confirmed by real-time quantitative polymerase chain reaction with AKR1B10 gene expression elevated sixfold in the liver. In contrast, AKR1B1 gene expression was reduced 40% in HCV-positive livers. Interestingly, persons who were formerly HCV infected retained the metabolomic phenotype of HCV infection without reverting to the HCV-negative metabolomic phenotype. This suggests that the effects of HCV on hepatic metabolism may be long lived. Hepatic AKR1B10 has been reported to be elevated in hepatocellular carcinoma and in several premalignant liver diseases. It would appear that HCV infection alone increases AKR1B10 expression, which manifests itself as enhanced urinary excretion of polyols with reduced urinary excretion of their corresponding hexoses. What role the polyols play in hepatic pathophysiology of HCV infection and its sequelae is currently unknown.
Prediction of Anticoagulation During Hemodialysis by Population Kinetics and an Artificial Neural Network (1998)

All systems currently used for routine hemodialysis require heparin administration to prevent blood clotting in the extracorporeal circuit. We tested the hypothesis that population-based statistical techniques can be used to predict heparin concentrations during routine hemodialysis. Two predictive models were developed, one based on nonlinear mixed effects modeling (NONMEM) and the other on a multilayer perceptron neural network. Serial clotting time data were obtained from forty-nine patients and used to develop the models. The models were used to predict the clotting times of 70 patients in a prospective test. We determined that the neural network provided greater precision, had fewer outliers in its predictions, and did not have the model misspecification in bolus administration that the NONMEM predictions demonstrated. A final NONMEM model was developed using all data from 119 patients to identify important covariates for predicting the heparin pharmacodynamic parameters, volume of distribution, and clearance. Both the volume of distribution and clearance increased following the initiation of dialysis and as the patient's baseline clotting time increased. The volume of distribution also increased as the patient's weight increased but was decreased by smoking and diabetes. Population-based statistical techniques may provide a useful alternative to existing methods for prescribing heparin.
Versatile compressive microscope for hyperspectral transmission and fluorescence lifetime imaging (2022)

Increasing demand for multimodal characterization and imaging of new materials entails the combination of various methods in a single microscopic setup. Hyperspectral imaging of transmission spectra or photoluminescence (PL) decay imaging count among the most used methods. Nevertheless, these methods require very different working conditions and instrumentation. Therefore, combining the methods into a single microscopic system is seldom implemented. Here we demonstrate a novel versatile microscope based on single-pixel imaging, where we use a simple optical configuration to measure the hyperspectral information, as well as fluorescence lifetime imaging (FLIM). The maps are inherently spatially matched and can be taken with spectral resolution limited by the resolution of the used spectrometer (3 nm) or temporal resolution set by PL decay measurement (120 ps). We verify the system's performance by its comparison to the standard FLIM and non-imaging transmission spectroscopy. Our approach enabled us to switch between a broad field-of-view and micrometer resolution without changing the optical configuration. At the same time, the used design opens the possibility to add a variety of other characterization methods. This article demonstrates a simple, affordable way of complex material studies with huge versatility for the imaging parameters.
A Fast Audio Clustering Using Vector Quantization and Second Order Statistics (2010)

This paper describes an effective unsupervised speaker indexing approach. We suggest a two stage algorithm to speed-up the state-of-the-art algorithm based on the Bayesian Information Criterion (BIC). In the first stage of the merging process a computationally cheap method based on the vector quantization (VQ) is used. Then in the second stage a more computational expensive technique based on the BIC is applied. In the speaker indexing task a turning parameter or a threshold is used. We suggest an on-line procedure to define the value of a turning parameter without using development data. The results are evaluated using 10 hours of audio data.
Next-generation sequencing library construction on a surface (2018)

We described the first study to construct libraries directly on a flowcell. We believe our technique could be incorporated into the existing Illumina sequencing pipeline to simplify the workflow, reduce costs, and improve data quality.
MEK inhibitors: a patent review 2008 – 2010 (2011)

The first MEK inhibitor was described in the literature in 1995, and several companies are still active in the research and development of MEK inhibitors for various disease states. The emerging role of MEK inhibitors in disease has prompted further investigations of this important target. The combination of MEK inhibitors with other agents/therapies in the treatment of diseases, particularly cancer, is a key development in the field.
Improved Spoken Document Retrieval With Dynamic Key Term Lexicon and Probabilistic Latent Semantic Analysis (PLSA) (2006)

Spoken document retrieval will be very important in the future network era. In this paper, we propose using a "dynamic key term lexicon" automatically extracted from the ever-changing document archives as an extra feature set in the retrieval task. This lexicon is much more compact but semantically rich, thus it can retrieve relevant documents more efficiently. The key terms include named entities and others selected by a new metric referred to as the term entropy here derived from probabilistic latent semantic analysis (PLSA). Various configurations of retrieval models were tested with a broadcast news archive in Mandarin Chinese and significant performance improvements were obtained, especially with the new version of PLSA models based on a key term lexicon rather than the full lexicon.
Figure S4 from Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer (2023)

&lt;p&gt;Supplementary Figure 4&lt;/p&gt;
METALLIC CONDUCTION OF DIAMOND LAYERS CONTAINING NANOSIZE Nd DISPERSIONS (1999)

Composite layers containing nanosized Nd grains dispersed in a diamond matrix have been produced by a new CVD-based technique. The electrical characterization performed in the range of 120-500 K shows a metal-like behaviour, with conductivity values reaching 2.8×106 Ohm-1 cm-1
Control of Molecular Orientation in Organic Semiconductor Films using Weak Hydrogen Bonds (2019)

Use of the intrinsic optoelectronic functions of organic semiconductor films has not yet reached its full potential, mainly because of the primitive methodology used to control the molecular aggregation state in amorphous films during vapor deposition. Here, a universal molecular engineering methodology is presented to control molecular orientation; this methodology strategically uses noncovalent, intermolecular weak hydrogen bonds in a series of oligopyridine derivatives. A key is to use two bipyridin-3-ylphenyl moieties, which form self-complementary intermolecular weak hydrogen bonds, and which do not induce unfavorable crystallization. Another key is to incorporate a planar anisotropic molecular shape by reducing the steric hindrance of the core structure for inducing π-π interactions. These synergetic effects enhance horizontal orientation in amorphous organic semiconductor films and significantly increasing electron mobility. Through this evaluation process, an oligopyridine derivative is selected as an electron-transporter, and successfully develops highly efficient and stable deep-red organic light-emitting devices as a proof-of-concept.
Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells (2021)

Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia. Although hypoxia-inducible factors (HIFs) are known as a main regulator, the mechanisms of EPO production have not been fully elucidated. In this study, we aimed to examine the roles of retinoic acid (RA) in EPO production using EPO-producing cells derived from human induced pluripotent stem cells (hiPSC-EPO cells) that we previously established. RA augmented EPO production by hiPSC-EPO cells under hypoxia or by treatment with prolyl hydroxylase domain-containing protein (PHD) inhibitors that upregulate HIF signals. Combination treatment with RA and a PHD inhibitor improved renal anemia in vitamin A-depleted CKD model mice. Our findings using hiPSC-EPO cells and CKD model mice may contribute to clarifying the EPO production mechanism and developing efficient therapies for renal anemia.
Refiners have several options for reducing gasoline benzene (1993)

Although the linkage between gasoline benzene content and evaporative, running, and tailpipe emission is not yet defined, the U.S. 1990 Clean Air Act Amendments mandate a benzene content of less than 1.0 vol% in reformulated gasolines. Likewise, the California Air Resources Board plans to restrict benzene to less than about 0.8 vol %. Mobil Research and Development Corp. and Badger Co. Inc. have developed several alternatives for reducing benzene levels in gasoline. Where benzene extraction is viable and maximum catalytic reformer hydrogen is needed, the companies' cumene and ethylbenzene processes are desirable. Mobil's benzene reduction process can be an alternative to benzene hydrosaturation. All of these processes utilize low-value offgas from the fluid catalytic cracking (FCC) unit.
Supplementary Figure Legends from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure Legends 1-4&lt;/p&gt;
Novel Water-Soluble Chitosan Derivatives/Quantum Dots Nanocomposite: Synthesis, Characterization and Photoluminescence Properties (2009)

Water-soluble biocompatible and monodisperse ZnS, CdS, CdSe quantum dots (QDs) were synthesized using natural chitosan derivatives as stabilizers. TEM, XRD, SAED and UV-vis confirmed the formation of nanoparticles with average size of 3-5 nm, and the resulted ZnS, CdS nanocrystals were shown to be of cubic and blended phase. It was found that the molecular structure of chitosan stabilizer had a large influence on the optical and crystalline properties of the QDs. Through refluxing, the surface defects of the nanoparticles were passivated and the photoluminescence were enhanced. The particle size and the photoluminescence intensity can be controlled through altering the concentration of precursor ions and stabilizer solution, the molar ratio of metal ions/[S2-] and refluxing time. The resulting biopolymer/QD composite can be potentially applied as biosensor or fluorescence tags in biological systems.
Multilocus Sequence Typing of Outbreak-Associated Listeria monocytogenes Isolates to Identify Epidemic Clones (2009)

STs associated with outbreaks (and representing previously designated ECs) appear to differ in their ecology. While association of ECI with multiple human listeriosis outbreaks appears to reflect strain abundance across environments, ECIa seems to represent an L. monocytogenes EC that appears to be overrepresented among outbreaks and sporadic cases and thus may have increased transmission potential.
QUANTIFICATION OF PREFORMED HLA ANTIBODIES BY FLOW CYTOMETRY IDENTIFIES PATIENTS AT RISK FOR STEROID RESISTANT AND STEROID SENSITIVE LIVER TRANSPLANT REJECTION. (2000)

Scornik, Juan C.; der Werf, Willem J. Van; Hemming, Alan W.; Reed, Alan I.; Pico, Consuelo Soldevilla; Howard, Richard J. Author Information
Psychiatrisches Handwerkszeug für den Hausarzt (1998)

Während des Studiums beziehungsweise im Rahmen des AiP ist es immer noch die Ausnahme, daß angehende Hausärzte sich als Wahlfach der Psychiatrie zuwenden. Dies führt dazu, daß man sich als Praktiker zwar noch oftmals an die "Ah"- und "Oh"-Erlebnisse erinnert, die die faszinierenden Schizophrenie-Patienten während der universitären Kurse hervorriefen, aber bislang sind nur sehr wenige Hausärzte in der Lage, eine halbwegs angemessene, sachliche Verhaltensbeschreibung im Sinne eines sogenannten psychopathologischen oder psychischen Befundes bei psychisch auffälligen Patienten abzugeben.
“What's in the Bowl, Bitch?” (1973)

(1973). “What's in the Bowl, Bitch?”. Transactional Analysis Journal: Vol. 3, No. 2, pp. 35-36.
THE EFFECTS OF PROSTAGLANDINS E2 AND F2α ADMINISTERED BY DIFFERENT ROUTES ON UTERINE ACTIVITY AND THE CARDIOVASCULAR SYSTEM IN PREGNANT AND NON‐PREGNANT WOMEN (1971)

Summary Prostaglandin E 2 and prostaglandin F 2α both stimulate the intact non‐pregnant and pregnant human uterus. Doses required to provide long lasting stimulation when given by intravenous, subcutaneous and intramuscular routes had no effect on the cardiovascular system. Both the non‐pregnant and the pregnant uterus during early pregnancy showed a similar sensitivity to prostaglandin E 2 and prostaglandin F 2α . The non‐pregnant uterus was not inhibited by prostaglandin E 2 at any dose level.
Fuzzy Regression Transfer Learning in Takagi–Sugeno Fuzzy Models (2016)

Data science is a research field concerned with processes and systems that extract knowledge from massive amounts of data. In some situations, however, data shortage renders existing data-driven methods difficult or even impossible to apply. Transfer learning has recently emerged as a way of exploiting previously acquired knowledge to solve new yet similar problems much more quickly and effectively. In contrast to classical data-driven machine learning methods, transfer learning methods exploit the knowledge accumulated from data in auxiliary domains to facilitate predictive modeling in the current domain. A significant number of transfer learning methods that address classification tasks have been proposed, but studies on transfer learning in the case of regression problems are still scarce. This study focuses on using transfer learning techniques to handle regression problems in a domain that has insufficient training data. We propose an original fuzzy regression transfer learning method, based on fuzzy rules, to address the problem of estimating the value of the target for regression. A Takagi-Sugeno fuzzy regression model is developed to transfer knowledge from a source domain to a target domain. Experimental results using synthetic data and real-world datasets demonstrate that the proposed fuzzy regression transfer learning method significantly improves the performance of existing models when tackling regression problems in the target domain.
Anterior Middle Chest Wall Reconstruction Using a Free Anterolateral Thigh Flap Resulted in Flail Chest: A Case Report (2019)

Supplemental Digital Content is available in the text.
Zero-field nuclear magnetic resonance in high field by modulated rf sequences (2007)

The authors propose a novel approach to design and evaluate sequences for zero-field NMR spectra in high field (ZFHF) by using amplitude and phase modulated rf sequences. ZFHF provide sharp peaks for the dipolar interaction between two nuclear spins even if the orientation of the molecules is distributed. The internuclear distance r can be directly obtained from the peak position which is proportional to r-3. Numerous ZFHF sequences are obtained. A sequence is selected from them by the systematic evaluation of the sequences. The new ZFHF sequence is less affected by chemical shift anisotropy (CSA) than the previous sequences; the sequence can be used for systems with large CSA such as a dipolar coupled 13C-pair system under realistically high field. 13C ZFHF spectra of 13C2 diammonium succinate and 13C2 diammonium oxalate were observed under the 9.4 T field.
Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection (2017)

Higher plasma sCD163 in life is associated with greater synaptodendritic damage and microglial activation in cortical and subcortical brain regions.
Headspace Solid Phase Microextraction and Gas Chromatography−Olfactometry Dilution Analysis of Young and Aged Chinese “Yanghe Daqu” Liquors (2005)

The aroma compounds of young and aged Chinese "Yanghe Daqu" liquor samples were extracted by solid phase microextraction (SPME) and analyzed by gas chromatography (GC)-olfactometry dilution analysis. The original liquor samples were diluted with deionized water to give a final alcohol content of 14% (v/v). The samples were stepwise diluted (1:1) with 14% (by volume) ethanol-water solution and then extracted by headspace SPME. The samples were preequilibrated at 50 degrees C for 15 min and extracted with stirring at the same temperature for 30 min prior to injection into GC. The aroma compounds were identified by both GC-MS and GC-olfactometry using DB-Wax and DB-5 columns. The results suggested that esters were the major contributors to Yanghe Daqu liquor aroma. Ethyl hexanoate, ethyl butanoate, and ethyl pentanoate had very high flavor dilution values in both young and aged liquors (FD > 8192). Methyl hexanoate, ethyl heptanoate, ethyl benzoate, and butyl hexanoate could also be very important because of their high flavor dilution values (FD > or = 256). Moreover, two acetals, 1,1-diethoxyethane and 1,1-diethoxy-3-methylbutane, also were shown high flavor dilution values in Yanghe Daqu liquors (FD > or = 256). Other aroma compounds having moderate flavor dilution values included acetaldehyde, 3-methylbutanol, and 2-pentanol (FD > or = 32). Comparing young and aged liquors, the aroma profiles were similar, but the aroma compounds in the aged sample had higher flavor dilution values than in the young ones.
Bilayer, nanoimprint lithography (2000)

Nanoimprint lithography has been shown to be a viable means of patterning polymer films in the sub-100 nm range. In this work, we demonstrate the use of a bilayer resist to facilitate the metal liftoff step in imprinter fabrication. The bilayer resist technology exhibits more uniform patterns and fewer missing features than similar metal nanoparticle arrays fabricated with single layer resist. The bilayer resist relies upon the differential solubility between poly(methyl methacrylate) and poly(methyl methacrylate methacrylic acid copolymer). Evidence is presented that shows the technique has a resolution of better than 10 nm.
Advanced Geotechnical Engineering (2013)

Soil-structure interaction is an area of major importance in geotechnical engineering and geomechanics Advanced Geotechnical Engineering: Soil-Structure Interaction using Computer and Material Models covers computer and analytical methods for a number of geotechnical problems. It introduces the main factors important to the application of computer
Non Trivial Computations in Anonymous Dynamic Networks (2016)

In this paper we consider a static set of anonymous processes, i.e., they do not have distinguished IDs, that communicate with neighbors using a local broadcast primitive. The communication graph changes at each computational round with the restriction of being always connected, i.e., the network topology guarantees 1-interval connectivity. In such setting non trivial computations, i.e., answering to a predicate like "there exists at least one process with initial input a?", are impossible. In a recent work, it has been conjectured that the impossibility holds even if a distinguished leader process is available within the computation. In this paper we prove that the conjecture is false. We show this result by implementing a deterministic leader-based terminating counting algorithm. In order to build our counting algorithm we first develop a counting technique that is time optimal on a family of dynamic graphs where each process has a fixed distance h from the leader and such distance does not change along rounds. Using this technique we build an algorithm that counts in anonymous 1-interval connected networks.
Comportement d’une réparation en escalier obtenue par Jet d’Eau Abrasif (2012)

Des éprouvettes carbone/époxy pour évaluer la qualité d’une réparation en escalier sont usinées, réparées puis testées mécaniquement. L’usinage préalable à la phase de réparation est effectué par Jet d’Eau abrasif, sous forme de marches régulières de ratio 1/30, et dont la profondeur correspond à l’épaisseur d’un pli. Le relâchement des contraintes résiduelles observé pendant la phase d’usinage est quantifié grâce à la technique de mesure de champs par stéréovision, et simulé par EF. La plaque usinée est ensuite reconstruite par remplacement des plis usinés, et cocuit en autoclave. Le schéma de stratification de la partie réparée est décalé d’un pli par rapport à la zone initiale, de manière à restituer le transfert de charges. Des éprouvettes sont découpées dans les plaques réparées, et sollicitées en traction. Les résultats montrent que les charges à rupture obtenues atteignent 70 % des charges à rupture d’éprouvettes «vierges». L’analyse des fragments des éprouvettes démontre que la rupture de la zone de collage dans les interfaces 0/0 est à l’origine de la rupture finale de toutes les éprouvettes. Le croisement essais/calcul conduit à l’évaluation d’un critère de rupture en contrainte de cisaillement admissible pour l’interface zone parent/patch.