gebhart/patrepeval huggingface dataset:
Adaptive Gate Bias for Power Amplifier Temperature Compensation (2011)

Mixed-mode device and circuit simulation is used to examine device self-heating during power amplifier (PA) transient response. Lattice temperature increases with time and eventually saturates beyond the thermal time constant. Temperature variation on the effect of PA performances has been modeled and analyzed. Different gate biasing schemes that reduce the temperature drift of PA output power and power-added efficiency are evaluated. A simple adaptive gate bias technique effectively provides temperature compensation of PA performances over a wide range of temperatures.
Preface (2018)

We are pleased to present the technical papers for IEEE VR 2018: the 25th IEEE Conference on Virtual Reality and 3D User Interfaces, held March 18-22, 2018 in Reutlingen, Germany. IEEE VR 2018 features two categories of submissions: (i) VR Journal Papers, and (ii) VR Conference Papers. Both categories have their own program committees, submission processes, and review processes. This year, 178 submissions were submitted to the Journal track from which 29 were accepted as articles to IEEE TVCG (16.3%). All of these will be presented at the IEEE VR 2018 conference, along with 6 additional papers in the VR area that were published in IEEE TVCG during the past year. Furthermore, 6 submission (3.4%) were recommended for a regular issue of TVCG with major revisions with reviewer continuity. Each of the papers in this special issue went through a rigorous two-round review process. All accepted journal papers are published in a special issue of IEEE Transactions on Visualization and Computer Graphics (TVCG). The Proceedings of the IEEE Conference on Virtual Reality and 3D User Interfaces contains all of the accepted conference papers and the poster abstracts.
Spray computers: frontiers of self-organization: frontiers of self-organization for pervasive computing (2004)

It is not hard to envision a future in which a network of microcomputers will be literally sold as spray cans, to be sprayed in an environment or on specific artifacts to enrich them with functionalities that, as of today, may appear futuristic and visionary: invisible clothes, intelligent interactive environments, self-assembly materials and self-repairing artifacts. However, the vision of spray computers may also act as a powerful metaphor for a range of other scenarios that are already under formation. These include distributed applications in embedded, possibly mobile, ad hoc networks, as well as distributed service- and data-oriented activities on the Internet. In fact, besides the different physical scale of the components involved and of their interactions (from microcomputers interacting within networks extending across a few meters, to Internet hosts interacting at a world-wide scale), all of these types of networks raise the same challenges for application development and deployment.
Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases (2011)

It can be concluded that percentage of stem cell-like prostate cancer cells has a prognostic impact especially on the risk of metastatic bone progression.
Surgical performance when inserting non-locking screws: a systematic review (2020)

Billions of screws are inserted by surgeons each year, making them the most commonly inserted implant. When using non-locking screws, insertion technique is decided by the surgeon, including how much to tighten each screw. The aims of this study were to assess, through a systematic review, the screw tightness and rate of material stripping produced by surgeons and the effect of different variables related to screw insertion.Twelve studies were included, with 260 surgeons inserting a total of 2793 screws; an average of 11 screws each, although only 1510 screws have been inserted by 145 surgeons where tightness was measured - average tightness was 78±10% for cortical (<i>n</i> = 1079) and 80±6% for cancellous screw insertions (<i>n</i> = 431).An average of 26% of all inserted screws irreparably damaged and stripped screw holes, reducing the construct pullout strength. Furthermore, awareness of bone stripping is very poor, meaning that screws must be considerably overtightened before a surgeon will typically detect it.Variation between individual surgeons' ability to optimally insert screws was seen, with some surgeons stripping more than 90% of samples and others hardly any. Contradictory findings were seen for the relationship between the tightness achieved and bone density.The optimum tightness for screws remains unknown, thus subjectively chosen screw tightness, which varies greatly, remains without an established target to generate the best possible construct for any given situation. Work is needed to establish these targets, and to develop methods to accurately and repeatably achieve them. Cite this article: <i>EFORT Open Rev</i> 2020;5:26-36. DOI: 10.1302/2058-5241.5.180066.
A RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, CONTROLLED DOSE COMPARISON OF THALIDOMIDE FOR TREATMENT OF ERYTHEMA NODOSUM LEPROSUM (2005)

In a randomized, double-blind, double-dummy controlled study, 22 men with erythema nodosum leprosum (ENL) received six capsules containing either 100 mg (group A, n = 12) or 300 mg (group B, n = 10) of thalidomide daily for one week. A six-week, four capsules per day taper followed, in which group A received 50 mg/day of thalidomide in weeks 2 and 3, then dummy capsules in weeks 4 through 7, while group B had gradual decrements every two weeks. Both regimens caused comparable improvement in 19 patients at day 7 (group A [12 of 12] versus group B [7 of 10]; P = 0.08), but slower tapering in group B showed less re-emergence of ENL through week 7 (P = 0.02, versus group A). Most patients developed new lesions soon after stopping treatment. Slower tapering from a higher initial thalidomide dose may improve clinical ENL responses, but high recurrence rates after discontinuation indicates further assessment is needed to identify better tapering regimens.
Visibility preprocessing for interactive walkthroughs (1991)

The number of polygons comprising interesting architectural models is many more than can be rendered at interactive frame rates. However, due to occlusion by opaque surfaces (e.g., walls), only a small fraction of a typical model is visible from most viewpoints.We describe a method of visibility preprocessing that is efficient and effective for axis-aligned or axial architectural models. A model is subdivided into rectangular cells whose boundaries coincide with major opaque surfaces. Non-opaque portals are identified on cell boundaries, and used to form an adjacency graph connecting the cells of the subdivision. Next, the cell-to-cell visibility is computed for each cell of the subdivision, by linking pairs of cells between which unobstructed sightlines exist.During an interactive walkthrough phase, an observer with a known position and view cone moves through the model. At each frame, the cell containing the observer is identified, and the contents of potentially visible cells are retrieved from storage. The set of potentially visible cells is further reduced by culling it against the observer's view cone, producing the eye-to-cell visibility. The contents of the remaining visible cells are then sent to a graphics pipeline for hidden-surface removal and rendering.Tests on moderately complex 2-D and 3-D axial models reveal substantially reduced rendering loads.
Secure Triplet Loss for End-to-End Deep Biometrics (2020)

Although deep learning is being widely adopted for every topic in pattern recognition, its use for secure and cancelable biometrics is currently reserved for feature extraction and biometric data preprocessing, limiting achievable performance. In this paper, we propose a novel formulation of the triplet loss methodology, designated as secure triplet loss, that enables biometric template cancelability with end-to-end convolutional neural networks, using easily changeable keys. Trained and evaluated for electrocardiogram-based biometrics, the network revealed easy to optimize using the modified triplet loss and achieved superior performance when compared with the state- of-the-art (10.63% equal error rate with data from 918 subjects of the UofTDB database). Additionally, it ensured biometric template security and effective template cancelability. Although further efforts are needed to avoid template linkability, the proposed secure triplet loss shows promise in template cancelability and non-invertibility for biometric recognition while taking advantage of the full power of convolutional neural networks.
An Adaptive Utilization Accelerator for Virtualized Environments (2014)

One of the key enablers of a cloud provider competitiveness is ability to over-commit shared infrastructure at ratios that are higher than those of other competitors, without compromising non-functional requirements, such as performance. A widely recognized impediment to achieving this goal is so called "Virtual Machines sprawl", a phenomenon referring to the situation when customers order Virtual Machines (VM) on the cloud, use them extensively and then leave them inactive for prolonged periods of time. Since a typical cloud provisioning system treats new VM provision requests according to the nominal virtual hardware specification, an often occurring situation is that the nominal resources of a cloud/pool become exhausted fast while the physical hosts utilization remains low.We present a novel cloud resources scheduler called Pulsar that extends OpenStack Nova Filter Scheduler. The key design principle of Pulsar is adaptivity. It recognises that effective safely attainable over-commit ratio varies with time due to workloads' variability and dynamically adapts the effective over-commit ratio to these changes. We evaluate Pulsar via extensive simulations and demonstrate its performance on the actual OpenStack based testbed running popular workloads.
An Error Protection Technique for the Wireless Transmission of Digital Cinema Streams (2005)

This paper presents a forward error correction technique that can be applied to protect digital cinema streams during their transmission over wireless channels with both sparse and packet error statistics, such as those provided by satellite broadcasting and wireless MAN standards as WiMAX. To this aim, we adopt the tools of the JPEG2000 wireless (JPWL) standard, by introducing a method for unequal error protection (UEP) and a virtual interleaving technique of the stream. In this way, not only the probability of frame loss is minimized, but also the average quality of the received video stream is maximized. In particular, we show that a proper combination of Reed-Solomon coding and virtual interleaving on the image data, can greatly improve the average PSNR of the reconstructed frames, in case of transmission on both the AWGN channel and the packet-loss channel. Moreover, the protected stream is still compliant with the Digital Cinema guidelines, thus providing a complete backward compatibility.
Quantification of Plasmodium falciparum Histidine-Rich Protein-2 in Cerebrospinal Spinal Fluid from Cerebral Malaria Patients (2014)

A cerebrospinal fluid (CSF) biomarker for cerebral malaria (CM) has not been validated. We examined the detection, semiquantification, and clinical use of the Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) as a parasite antigen biomarker for CM. The PfHRP-2 was detected in archival CSF samples from CM patients from Tanzania both by a newly developed sensitive and specific immuno-polymerase chain reaction (72 of 73) and by rapid diagnostic tests (62 of 73). The geometric mean PfHRP-2 CSF concentration was 8.76 ng/mL with no differences in those who survived (9.2 ng/mL), those who died (11.1 ng/mL), and those with neurologic sequelae (10.8 ng/mL). All aparasitemic endemic and nonendemic control samples had undetectable CSF PfHRP-2. In a separate group of 11 matched plasma and CSF cerebral malaria patient samples, the ratio of plasma to CSF PfHRP-2 was 175. The CSF PfHRP-2 reflects elevated plasma PfHRP-2 rather than elevated CM-specific CSF ratios, falling short of a validated biomarker.
p53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin (2015)

BACKGROUND: The role of p53 in the pathogenesis of skin diseases such as plaque-type psoriasis has long been questioned but never resolved. OBJECTIVES: In this study we set out to determine the contribution of p53 activity to defective interfollicular epidermal skin differentiation in a murine hyperproliferative skin model. METHODS: We used the tamoxifen-inducible K14MycER mouse model which exhibits abnormal epidermal differentiation in response to high MYC activity, crossed with p53 knock-out mice. Results- We show that genetic deletion of p53 leads to improvements in granular layer formation. Furthermore, we show that p53 activity regulates down-stream expression of Keratin 6a, Pparb/d and Pparg and is regulated upstream by retinoic acid signalling-dependent mechanisms. CONCLUSION: We conclude aberrant non-apoptotic p53 activity contributes, in-part, to abnormal differentiation and granular layer defects. This article is protected by copyright. All rights reserved.
Laser Inter-Satellite Link Setup Delay: Quantification, Impact, and Tolerable Value (2023)

Dynamic laser inter-satellite links (LISLs) provide the flexibility of connecting a pair of satellites as required (dynamically) while static LISLs need to be active continuously between the energy-constrained satellites. However, due to the LISL establishment time (termed herein as LISL setup delay) being in the order of seconds, realizing dynamic LISLs is currently unfeasible. Towards the realization of dynamic LISLs, we first study the quantification of LISL setup delay; then we calculate the end-to-end latency of a free-space optical satellite network (FSOSN) with the LISL setup delay; subsequently, we analyze the impact of LISL setup delay on the end-to-end latency of the FSOSN. We also provide design guidelines for the laser communication terminal manufacturers in the form of maximum tolerable value of LISL setup delay for which the FSOSN based on Starlink’s Phase I satellite constellation will be meaningful to use for low-latency long-distance inter-continental data communications.
Androgen Receptor Survival Signaling Is Blocked by Anti-β2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells (2010)

A new cis-acting element, sterol regulatory element-binding protein-1 (SREBP-1) binding site, within the 5'-flanking human androgen receptor (AR) promoter region and its binding transcription factor, SREBP-1, was identified to regulate AR transcription in AR-positive human prostate cancer cells. We further characterized the molecular mechanism by which a novel anti-beta2-microglobulin monoclonal antibody (beta2M mAb), shown to induce massive cell death in a number of human and mouse cancer cell lines, interrupted multiple cell signaling pathways in human prostate cancer cells. beta2M mAb decreased AR expression through inactivation of MAPK and SREBP-1. By inactivation of MAPK, beta2M mAb decreased prostate cancer cell proliferation and survival. By inhibition of SREBP-1, beta2M mAb reduced fatty acid and lipid levels, an integral component of cell membrane, cell signaling mediators, and energy metabolism. These results provide for the first time a molecular link between the beta2M intracellular signaling axis mediated by MAPK and SREBP-1 and involving lipid signaling, which collectively regulates AR expression and function. Antagonizing beta2M by beta2M mAb may be an effective therapeutic approach simultaneously targeting multiple downstream signaling pathways converging with MAPK, SREBP-1, and AR, important for controlling prostate cancer cell growth, survival, and progression.
Letters to the Editor (1951)

Letters to the Editor J. B. Atkins, J. B. Atkins Search for other works by this author on: Oxford Academic PubMed Google Scholar E. H. Capel, E. H. Capel Search for other works by this author on: Oxford Academic PubMed Google Scholar P. B. Cunningham, P. B. Cunningham Search for other works by this author on: Oxford Academic PubMed Google Scholar J. F. Erskine, J. F. Erskine Search for other works by this author on: Oxford Academic PubMed Google Scholar H. J. Friend, H. J. Friend Search for other works by this author on: Oxford Academic PubMed Google Scholar R. F. L. Logan, R. F. L. Logan Search for other works by this author on: Oxford Academic PubMed Google Scholar N. MacDonald, N. MacDonald Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Makin, R. Makin Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. Owston, A. J. Owston Search for other works by this author on: Oxford Academic PubMed Google Scholar F. A. Shackleton F. A. Shackleton Search for other works by this author on: Oxford Academic PubMed Google Scholar Occupational Medicine, Volume 1, Issue 3, October 1951, Pages 159–160, https://doi.org/10.1093/occmed/1.3.159 Published: 01 October 1951
Catalytic Study of Methanol-to-Olefins Conversion in Four Small-Pore Silicoaluminophosphate Molecular Sieves:  Influence of the Structural Type, Nickel Incorporation, Nickel Location, and Nickel Concentration (2000)

The selectivity of four small-pore silicoaluminophosphate molecular sieves, including SAPO-34 (CHA), SAPO-35 (LEV), SAPO-17 (ERI), and SAPO-18 (AEI), toward light olefins in general and ethylene in particular has been investigated for the methanol-to-olefins reaction using gas chromatography. This study was prompted by earlier electron spin resonance and electron spin−echo modulation results on nickel-modified SAPO materials in which Ni(I) was incorporated into both framework and ion-exchanged sites. These seemingly similar materials behaved significantly differently with respect to reducing agents and adsorbates. Attention was focused on whether the catalyst performance is influenced by the structural type, the presence of a transition metal ion (Ni) either in the framework or at ion-exchanged positions, or the amount of incorporated transition metal ion. Our results show that these factors indeed play an important role in the catalytic behavior. Among the protonated H−SAPO-n materials, the highest combined distribution of ethylene, propylene, and butenes (C2−C4 olefins) was obtained with H−SAPO-34, and the lowest with H−SAPO-35, which also had the shortest lifetime for catalytic activity. H−SAPO-18 turned out to be the best catalyst in terms of lifetime for catalytic activity. Incorporation of Ni(II) into the framework increased the lifetime, the overall distribution of C2−C4 olefins (in the case of NiAPSO-34), and the selectivity of the catalysts toward ethylene (in the cases of NiAPSO-34 and NiAPSO-18), whereas incorporation of Ni(II) by means of solid-state ion exchange (NiH−SAPO-n) increased only the selectivity toward ethylene. Also, the increase in ethylene selectivity was more prominent in synthesized than in ion-exchanged samples. Among the Ni-loaded samples, NiAPSO-34 was found to be the best catalyst in terms of both ethylene selectivity and lifetime, whereas NiH−SAPO-18 exhibited the worst ethylene yield and NiH−SAPO-35 the shortest lifetime. Finally, the effect of the amount of Ni was investigated in NiAPSO-34. It appears that the selectivity toward ethylene does not increase linearly with NiAPSO samples prepared with an increasing amount of Ni in the reaction gel. In fact, there seems to be an optimum Ni concentration for which ethylene selectivity reaches a maximum and above which ethylene selectivity decreases. This optimum concentration is the same as was found in earlier studies to yield the strongest Ni(I) signal, as observed by ESR.
Layer-by-Layer Self-Assembly of Glucose Oxidase with a Poly(allylamine)ferrocene Redox Mediator (1997)

We report the redox mediation of glucose oxidase (GOx) in a self-assembled structure of cationic poly(allylamine) modified by ferrocene (PAA-Fc) and anionic GOx deposited electrostatically layer-by-layer on negatively charged alkanethiol-modified Au surfaces. Successive PAA-Fc and GOx layers were deposited by alternate immersion of the thiol-modified Au in the respective polyelectrolyte and enzyme solutions. The uptake of thiol, redox polymer, and GOx on the surface was monitored by quartz crystal microbalance. Cyclic voltammetry shows nearly ideal surface waves of ferrocene in the polymer with charge independent of sweep rate; the redox surface concentration was obtained from integration of the ferrocene/ferricinium voltammetric peaks. The redox charge increases in step with the number of PAA-Fc layers deposited. Enzyme catalysis for the oxidation of β-d-glucose was achieved with a multilayer PAA-Fc/GOx assembly, with each GOx layer contributing equally to the catalytic response. Only a small fraction of the active assembled GOx molecules are “electrically wired” by the ferrocene polymer although all of the enzyme could be oxidized by soluble ferrocenesulfonate when added to solution.
Kinetische15N-CPMAS-NMR-Untersuchungen einer Doppelprotonenwanderung in einem kristallinen Malonaldehyddiimin-Derivat (1987)

Festkörpereffekte verursachen einen Energieunterschied von etwa 4 kJ mol−1 zwischen den Tautomeren 1 und 2. Dies ließ sich aus dynamischen 15N-NMR-Spektren ableiten, die unter den Bedingungen der Kreuzpolarisation und der Probenrotation um den magischen Winkel aufgenommen wurden.
Statistical bilinearization in stochastic nonlinear dynamics (2002)

A response approximation method for stochastically excited, nonlinear, dynamic systems is presented. Herein, the output of the nonlinear system is approximated by a finite-order Volterra series. The original, nonlinear system is replaced by a bilinear system in order to determine the kernels of this Volterra series. The parameters of the bilinear system are determined by minimizing the difference between the original system and the bilinear system in a statistical sense. Application to a piece-wise linear system illustrates the effectiveness of this approach in approximating truly nonlinear, stochastic response phenomena in both the statistical moments and the power spectral density of the response of this system in case of a white noise excitation.
Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state (2022)

The mechanosensitive ion channel of large conductance MscL gates in response to membrane tension changes. Lipid removal from transmembrane pockets leads to a concerted structural and functional MscL response, but it remains unknown whether there is a correlation between the tension-mediated state and the state derived by pocket delipidation in the absence of tension. Here, we combined pulsed electron paramagnetic resonance spectroscopy and hydrogen-deuterium exchange mass spectrometry, coupled with molecular dynamics simulations under membrane tension, to investigate the structural changes associated with the distinctively derived states. Whether it is tension- or modification-mediated pocket delipidation, we find that MscL samples a similar expanded subconducting state. This is the final step of the delipidation pathway, but only an intermediate stop on the tension-mediated path, with additional tension triggering further channel opening. Our findings hint at synergistic modes of regulation by lipid molecules in membrane tension-activated mechanosensitive channels.