gebhart/patrepeval huggingface dataset:
A UV-exposure system using DMD (2000)

The digital micromirror device (DMD) is a new display device fabricated by the micromachining technique and used in projectors. In this paper, the DMD serves as an ultraviolet exposure system and is tested in applications for projection exposure systems and rapid prototyping. © 2000 Scripta Technica, Electron Comm Jpn Pt 2, 83(7): 56–58, 2000
The Effect of Vanadium on Physicochemical and Electrochemical Performances of LiFePO[sub 4] Cathode for Lithium Battery (2010)

The phase compositions of the -based cathode materials upon varying the adding amount of vanadium from 0 to 0. 13 are systemically investigated. A corresponding concentration–composition phase diagram is presented, and the -dependent variations in the physiochemical and electrochemical performances are systemically analyzed. In the whole concentration range, the chemical valence of remains invariant whereas the valence of vanadium evolves from to . With the increase of adding amount of vanadium, the electrical conductivity of samples varies nonlinearly as an "N" shape while the lithium ion diffusion coefficient first increases and then decreases. The doping of vanadium is beneficial to refine the particle size and increase the electrical conductivity. Upon doping, the reversibility of the electrochemical reaction and the rate capability are monotonically enhanced. The conductive modifies the interface property of nanoparticles, and the sample achieves the high power density without sacrificing the energy density due to pesudocapacitive behavior. The formation of is more beneficial to improve the rate capacity of the -based cathode, although it undermines the lithium-ion transport of the main phase. By optimizing the content of , excellent rate capacity and high specific capacity can be achieved.
Unoccupied-state electronic structure in (NiyPt1−y)75P25andNi100−xPxmetallic glasses (1985)

The ${L}_{\mathrm{I}\mathrm{I}\mathrm{I},\mathrm{I}\mathrm{I}}$-edge x-ray absorption near-edge structure (XANES) of Pt and the K-edge XANES of Ni have been measured for the amorphous (${\mathrm{Ni}}_{\mathrm{y}}$${\mathrm{Pt}}_{1\mathrm{\ensuremath{-}}\mathrm{y}}$${)}_{75}$${\mathrm{P}}_{25}$ system. The Ni-K-edge XANES in roller-quenched amorphous ${\mathrm{Ni}}_{100\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{P}}_{\mathrm{x}}$, and Ni-${L}_{\mathrm{III}}$-edge XANES in electrodeposited amorphous ${\mathrm{Ni}}_{100\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{P}}_{\mathrm{x}}$ have also been obtained. Results on (${\mathrm{Ni}}_{\mathrm{y}}$${\mathrm{Pt}}_{1\mathrm{\ensuremath{-}}\mathrm{y}}$${)}_{75}$${\mathrm{P}}_{25}$ agree qualitatively with expectations based on recent relativistic Korringa-Kohn-Rostoker coherent-potential-approximation (KKR-CPA) calculations for ${\mathrm{Ni}}_{\mathrm{x}}$${\mathrm{Pt}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$ solid solutions. Similar agreement is found between our experimental results on ${\mathrm{Ni}}_{100\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{P}}_{\mathrm{x}}$ and recent KKR-CPA calculations for this system. No evidence is found for Pt or Ni d-hole filling in any of these metallic glasses. Finally, our results on electrodeposited ${\mathrm{Ni}}_{100\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{P}}_{\mathrm{x}}$ are similar to previous measurements on chemically deposited ${\mathrm{Ni}}_{80}$${\mathrm{P}}_{20}$ carried out by others.
Nucleosides. XXXIII. N4-Acylated 5-Fluorocytosines and a Direct Synthesis of 5-Fluoro-2'-deoxycytidine1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleosides. XXXIII. N4-Acylated 5-Fluorocytosines and a Direct Synthesis of 5-Fluoro-2'-deoxycytidine1R. Duschinsky, T. Gabriel, M. Hoffer, J. Berger, E. Titsworth, E. Grunberg, J. H. Burchenal, and J. J. FoxCite this: J. Med. Chem. 1966, 9, 4, 566–572Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://doi.org/10.1021/jm00322a028Request reuse permissionsArticle Views196Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (878 KB) Get e-Alertsclose Get e-Alerts
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain (2004)

A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and dehydroepiandrosterone (DHEA-S) in rat brain. Using a solid-phase extraction recycling protocol, the results show that little or no PREG-S and DHEA-S (<1 pmol/g) is present in rat and mouse brain. These data are in agreement with studies in which steroid sulfates were analyzed without deconjugation. We suggest that the discrepancies between analyses with and without deconjugation are caused by internal contamination of brain extract fractions, supposed to contain steroid sulfates, by lipoidal forms of PREG and DHEA (L-PREG and L-DHEA, respectively). These derivatives can be acylated very efficiently with heptafluorobutyric anhydride and triethylamine, and their levels in rodent brain (approximately 1 nmol/g) are much higher than those of their unconjugated counterparts. They are distinct from fatty acid esters, and preliminary data do not favor structures such as sulfolipids or sterol peroxides. Noncovalent interactions between steroids and proteolipidic elements, such as lipoproteins, could account for some experimental data. Given their abundance in rodent brain, the structural characterization and biological functions of L-PREG and L-DHEA in the central nervous system merit considerable attention.
Video-based hypermedia for education-on-demand (1998)

Networked Hyper QuickTime (NHQT) is a prototype education-on-demand system for annotated video over the Internet. NHQT uses World Wide Web, Gopher and QuickTime technologies to deliver video streams with embedded uniform resource locators that point to ancillary documents or video streams. NHQT's video-based user interface supports VCR-style playback control, random positioning, content-based searching and automatic resolution of hypermedia links for Internet access.
Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5) (2014)

Soluble Amyloid-β oligomers (Aβo) can trigger Alzheimer disease (AD) pathophysiology by binding to cell surface cellular prion protein (PrP(C)). PrP(C) interacts physically with metabotropic glutamate receptor 5 (mGluR5), and this interaction controls the transmission of neurotoxic signals to intracellular substrates. Because the interruption of the signal transduction from PrP(C) to mGluR5 has therapeutic potential for AD, we developed assays to explore the effect of endogenous ligands, agonists/antagonists, and antibodies on the interaction between PrP(C) and mGluR5 in cell lines and mouse brain. We show that the PrP(C) segment of amino acids 91-153 mediates the interaction with mGluR5. Agonists of mGluR5 increase the mGluR5-PrP(C) interaction, whereas mGluR5 antagonists suppress protein association. Synthetic Aβo promotes the protein interaction in mouse brain and transfected HEK-293 cell membrane preparations. The interaction of PrP(C) and mGluR5 is enhanced dramatically in the brains of familial AD transgenic model mice. In brain homogenates with Aβo, the interaction of PrP(C) and mGluR5 is reversed by mGluR5-directed antagonists or antibodies directed against the PrP(C) segment of amino acids 91-153. Silent allosteric modulators of mGluR5 do not alter Glu or basal mGluR5 activity, but they disrupt the Aβo-induced interaction of mGluR5 with PrP(C). The assays described here have the potential to identify and develop new compounds that inhibit the interaction of PrP(C) and mGluR5, which plays a pivotal role in the pathogenesis of Alzheimer disease by transmitting the signal from extracellular Aβo into the cytosol.
A cross-modal adaptation approach for brain decoding (2017)

Brain decoding has become a hot topic in many recent brain studies. In a typical neuroimaging experiment, participants are presented with different categories of stimuli while their concurrent brain activity is recorded. Then a classifier is trained on the features extracted from the recorded brain data to discriminate different target stimuli classes. It is a common practice to hypothesize that the stimulus-related information exists in the brain data if the decoder can accurately predict the target stimulus category. However, most of the neuroimaging studies suffer from few and noisy samples. These constraints affects the performance of such decoding systems. In order to cope with this limitation, a dictionary learning approach is used in this paper to transfer knowledge from the multimedia domain to the brain domain. We show that such cross-modal domain adaptation yields better performance of the learning algorithm in the brain domain. This is the first study in the direction of cross-modal adaptation by joint dictionary learning on multimedia and brain modality.
Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis (2014)

Time-course transcriptional profiling of P. chrysogenum revealed differentially expressed genes during co-cultivation with B. subtilis. Penicillin production was not induced under these conditions. However, induction of a newly characterized P. chrysogenum gene encoding α-1,3 endoglucanase may enhance the efficacy of fungal antibiotics by degrading bacterial exopolysaccharides.
Electrophoretic profile of pineal gland homogenate during follicular and luteal phases of oestrous cycle in goats (2007)

Electrophoretic profile ofprotein/peptides present in the pineal gland, obtained from female goats during follicular and luteal phase ofoestrous cycle, was studied. Extracts prepared from the pineal gland during these phases ofoestrous cycle were ?,10kDa and electrophoresed under denaturing discontinuous conditions with constant voltage. Follicular and luteal phase fractions showed presence of33 and 24 protein bands respectively. The protein bands having molecular weights .. 11,13.5,14,33,46,54,94 and 100 kDa were absent in pineal fractions obtained during luteal phase. The present study indicated considerable variation in pineal protein/peptide electrophoretic profile with respect to stage of oestrous cycle.
A New Synthesis of Rizatriptan Based on Radical Cyclization (2008)

A new methodology useful for preparation of indole derivatives bearing a 2-(dialkylamino)-ethyl substituent at the 3-position has been developed. Application of this methodology to the synthesis of N , N -dimethyl-2-{5-[(1 H -1,2,4-triazol-1-yl)methyl]-1 H -indol-3-yl}ethan-1-amine (rizatriptan; 3 ) is described. The key reaction step is based on the radical cyclization of N -[4-(dimethylamino)but-2-yn-1-yl]- N -{2-iodo-4-[(1 H -1,2,4-triazol-1-yl)methyl]phenyl}-acetamide ( 21 ), easily available by the Mannich reaction, and subsequent isomerization of the primarily formed methylidene derivative 22 .
Light Beams With a Twist Could Give a Turbo Boost to Fiber-Optic Cables (2013)

Giving photons a twist may sharply boost the amount of data that can be sent through optical fibers.
SIGN: War-Driving Free Indoor Navigation Using Coded Visual Tags (2018)

Recent advance in Internet-of-Things (IoT) brings consumer- level smart mobile robot to our life. Indoor navigation is one of the most critical challenges for mobile robots. Existing approaches using wireless signal fingerprinting (e.g., WiFi fingerprint), computer vision techniques, require extensive war-driving of the indoor environment to collect sufficient environmental data. In this paper, we present SIGN, a lightweight, visual-tag based, indoor navigation approach that is free of indoor war-driving. The approach deploys a set of coded visual tags in the environment, and allows the robot to autonomously decide the moving direction by recognizing nearby tags and leveraging the geometry information. The proposed approach is robust to the change of the environment such as unexpected obstacles. Experiments in two indoor spaces under various scenarios show that SIGN helps the mobile robot using the off-the- shelf camera to self-navigate in indoor environment with the deployment of coded visual tags.
Carbene durch thermische Cycloeliminierung (1971)

Abstract Das zunehmende Interesse an Carbenen verlangt Methoden, mit denen man diese Zwischenstufen in unimolekularen Zerfallsprozessen – gegebenenfalls in der Gasphase – ohne störende Nebenprodukte erzeugen kann. Dazu haben sich neben dem Zerfall von Diazoverbindungen thermische Cycloeliminierungen aus Carbo‐ und Heterocyclen ungerader Gliederzahl bewährt. In diesem Fortschrittsbericht werden Probleme, strukturelle Voraussetzungen und Anwendungsbreite derartiger Cycloeliminierungsreaktionen diskutiert. Am Beispiel der anderweitig nur sehr schlecht zugänglichen Dialkoxycarbene lassen sich die Vorteile der Carbenerzeugung durch thermische Cycloeliminierung aufzeigen.
Energy consumption characterization in precision hard machining using CBN cutting tools (2015)

In this paper, the contribution of tool wear to the energy balance was determined for precision hard turning using chamfered CBN cutting tools. The tool nose wear VBC and the corresponding changes of component forces F c, F f and F p resulting from tool wear evolution were continuously measured during wear tests. Based on the cutting mechanics, specific cutting and ploughing energies were calculated for a number of tool wear states. In particular, changes of energy balance due to tool wear under variable feed rate, depth of cut and tool nose radius were discussed. A distinction between material removal conditions resulting from precision cutting and grinding at a very low uncut chip thickness is considered.
Cover Picture: Total Synthesis and Biological Evaluation of (+)‐Gambieric Acid A and Its Analogues (Chem. Eur. J. 17/2013) (2013)

The first total synthesis of (+)-gambieric acid A, a potent antifungal marine polycyclic ether, has been accomplished by H. Fuwa, M. Sasaki et al. in their Full Paper on page 5276 ff. in a convergent manner by relying on Suzuki–Miyaura reaction for the assembly of the A/BCD- and F′GHIJ-ring fragments and a ring-closing metathesis for formation of the nonacyclic backbone. The total synthesis unambiguously establishes the structure of this extraordinary complex molecule, thus demonstrating the important role of organic synthesis in the structural elucidation of natural products.
Light-output enhancement in a nitride-based light-emitting diode with 22° undercut sidewalls (2004)

We successfully fabricated nitride-based light-emitting diodes (LEDs) with ∼22° undercut sidewalls. The ∼22° etching undercut sidewalls were achieved by controllable inductively coupled plasma reactive ion etching. With a 20-mA current injection, the output powers of the LED with ∼22° undercut sidewalls and standard LED were 5.1 and 3 mW, respectively - a factor of 1.7 times enhancement. It was found that such undercut sidewalls could enhance the probability of escaping the photons outside from the LED in the near horizontal and in-plane directions. This simple and controllable method is beneficial to fabricate brighter LEDs.
Modeling Lumen Output (2007)

This chapter contains sections titled: Simplified Model Light Collection and Étendue Integrators and Lumen Throughput Microdisplay and Light-valve Properties Full Colorimetric Model of the Projector Problems with Lumen Throughput Calculations Lumen Output Variation in Production References
Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha (1998)

The 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) family of proteins regulates the levels of the active 17 beta-hydroxy forms of sex steroids. The expression of 17 beta-HSD type IV is induced by peroxisome proliferator chemicals (PPC) in rat liver. In order to characterize more generally the impact of PPC on 17 beta-HSD expression, we determined (1) if expression of other members of the 17 beta-HSD family was coordinately induced by PPC exposure, (2) the tissues in which 17 beta-HSD was induced by PPC, and (3) whether the induction of 17 beta-HSD by PPC was dependent on the peroxisome proliferator-activated receptor alpha (PPAR alpha), the central mediator of PPC effects in the mouse liver. The mRNA levels of 17 beta-HSD I, II, and III were not altered in the liver, kidney, and testis or uterus of rats treated with PPC. The mRNA or 80 kDa a full-length protein levels of 17 beta-HSD IV were strongly induced in liver and kidney, but not induced in adrenals, brown fat, heart, testis, and uterus of rats treated with diverse PPC. In liver and kidneys from treated rats, additional proteins of 66 kDa, 56 kDa, and 32 kDa were also induced which reacted with the anti-17 beta-HSD IV antibodies and were most likely proteolytic fragments of 17 bega-HSD IV. Treatment of mice which lack a functional form of PPAR alpha with PPC, demonstrated that PPC-inducibility of 17 beta-HSD IV mRNA or the 80 kDa protein was dependent on PPAR alpha expression in liver and kidney. Our results demonstrate that 17 beta-HSD IV is induced by PPC through a PPAR alpha-dependent mechanism and support the hypothesis that exposure to PPC leads to alterations in sex steroid metabolism.
Evaluation of convolutional neural networks for visual recognition (1998)

Convolutional neural networks provide an efficient method to constrain the complexity of feedforward neural networks by weight sharing and restriction to local connections. This network topology has been applied in particular to image classification when sophisticated preprocessing is to be avoided and raw images are to be classified directly. In this paper two variations of convolutional networks--neocognitron and a modification of neocognitron--are compared with classifiers based on fully connected feedforward layers (i.e., multilayer perceptron, nearest neighbor classifier, auto-encoding network) with respect to their visual recognition performance. Beside the original neocognitron a modification of the neocognitron is proposed which combines neurons from perceptron with the localized network structure of neocognitron. Instead of training convolutional networks by time-consuming error backpropagation, in this work a modular procedure is applied whereby layers are trained sequentially from the input to the output layer in order to recognize features of increasing complexity. For a quantitative experimental comparison with standard classifiers two very different recognition tasks have been chosen: handwritten digit recognition and face recognition. In the first example on handwritten digit recognition the generalization of convolutional networks is compared to fully connected networks. In several experiments the influence of variations of position, size, and orientation of digits is determined and the relation between training sample size and validation error is observed. In the second example recognition of human faces is investigated under constrained and variable conditions with respect to face orientation and illumination and the limitations of convolutional networks are discussed.
Effects of cold working and heat treatment on microstructure and wear behaviour of Cu–Be alloy C17200 (2015)

The effects of cold work process between aging and solution heat treatment on the microstructure, hardness and the tribologic behaviour of a copper–beryllium (Cu–Be) alloy C17200 were investigated. The wear behaviour of the alloys was studied using ‘pin on disc’ method under dry conditions. The results show that the formation of fine grained structure and γ phase particles enhances the mechanical properties of the alloy; nonetheless, they do not reduce the wear rate. This is attributed to the capability of the softer specimens to maintain oxygen rich compounds during the dry sliding test.
GSK2878175, a pan‐genotypic non‐nucleoside NS5B polymerase inhibitor, in healthy and treatment‐naïve chronic hepatitis C subjects (2017)

GSK2878175 is a potent, pan-genotypic, non-nucleoside, nonstructural protein 5B palm polymerase inhibitor being developed for the treatment of chronic hepatitis C (CHC). A first-in-human, randomized, placebo-controlled, dose escalation study, evaluated the safety and pharmacokinetics of GSK2878175 administered as single and repeat oral doses (once daily for 14 days) to healthy volunteers. A separate proof-of-concept, placebo-controlled, repeat dose (once daily for 2 days) study evaluated the safety, pharmacokinetics and antiviral activity of GSK2878175 monotherapy in treatment-naïve, noncirrhotic, subjects with hepatitis C virus (HCV) genotype 1 [1a and 1b], 2, or 3. No deaths or SAEs were reported in either study, and treatment was well-tolerated. Across all the HCV genotypes, GSK2878175 monotherapy at doses of 10, 30 or 60 mg once daily for 2 days produced a statistically significant multilog reduction (P<.001) in plasma HCV RNA log<sub>10</sub> IU/mL from Baseline to 24, 48 and 72 hours after the first dose of GSK2878175 compared to placebo. The reduction in HCV RNA was sustained for a prolonged period across all of the active treatment groups, consistent with the long apparent half-life of GSK2878175 that was observed (mean t<sub>1/2</sub> range: 60-63 hours in the CHC subjects). In summary, GSK2878175, when administered to healthy subjects and subjects with CHC, did not reveal any safety concerns that would limit or preclude further clinical development. GSK2878175 monotherapy across a wide dose range produced substantial reduction in HCV RNA, irrespective of HCV genotype. The results from these studies support further evaluation of GSK2878175-based regimens.