gebhart/patrepeval huggingface dataset:
Specific and Sensitive Diagnosis of Babesia microti Active Infection Using Monoclonal Antibodies to the Immunodominant Antigen BmGPI12 (2022)

The apicomplexan pathogen Babesia microti is responsible for most cases of human babesiosis worldwide. The disease, which presents as a malaria-like illness, is potentially fatal in immunocompromised or elderly patients, making the need for its accurate and early diagnosis an urgent public health concern. B. microti is transmitted primarily by <i>Ixodes</i> ticks but can also be transmitted via blood transfusion. The parasite completes its asexual reproduction in the host red blood cell, where each invading merozoite develops and multiplies to produce four daughter parasites. While various techniques, such as microscopy, PCR, and indirect fluorescence, have been used over the years for babesiosis diagnosis, detection of the secreted B. microti immunodominant antigen BmGPI12 using specific polyclonal antibodies was found to be the most effective method for the diagnosis of active infection and for evaluation of clearance following drug treatment. Here, we report the development of a panel of 16 monoclonal antibodies against BmGPI12. These antibodies detected secreted BmGPI12 in the plasma of infected humans. Antigen capture assays identified a combination of two monoclonal antibodies, 4C8 and 1E11, as a basis for a monoclonal antibody-based BmGPI12 capture assay (mGPAC) to detect active B. microti infection. Using a collection of 105 previously characterized human plasma samples, the mGPAC assay showed 97.1% correlation with RNA-based PCR (transcription-mediated amplification [TMA]) for positive and negative samples. The mGPAC assay also detected BmGPI12 in the plasma of six babesiosis patients at the time of diagnosis but not in three matched posttreatment samples. The mGPAC assay could thus be used alone or in combination with other assays for accurate detection of active B. microti infection.
Temperature-Dependent Terahertz Time-Domain Spectroscopy of Mg-doped Stoichiometric Lithium Niobate (2020)

The absorption coefficient and refractive index spectra of 0.7 mol% Mg-doped stoichiometric lithium niobate were determined in the terahertz frequencies. The phase-matching parameters extracted from time-domain measurements were given in a wide temperature range.
OBTENÇÃO DA FORMA 3D DE OBJECTOS ATRAVÉS DE MÉTODOS VOLUMÉTRICOS (2009)

Neste trabalho pretendeu-se realizar a reconstrucao e caracterizacao tridimensional (3D) de objectos a partir de imagens bidimensionais (2D). Para tal, utilizaram-se metodos volumetricos, que se caracterizam por representar o modelo final por um conjunto finito de primitivas geometricas 3D, usualmente designadas por voxels. Assim, utilizando uma sequencia de imagens adquiridas em torno do objecto a reconstruir, calibrou-se a câmara usada, determinaram-se as poses associadas a cada imagem e construiram-se os modelos 3D do objecto em questao usando metodos volumetricos. O objectivo final foi analisar a exactidao dos modelos obtidos ao variar alguns dos parâmetros dos metodos volumetricos considerados, tais como o tipo de projeccao dos voxels considerada e o modo de classificacao dos voxels.
Application of DFTB in molecular electronics (2006)

... in molecular electronics. Jeffrey R Reimers, Gemma C. Solomon, Zheng-Li Cai, Noel S. Hush, ... Theoretical Physics Department, University of Bremen, Germany ... &ndash; A free PowerPoint PPT presentation (displayed as an HTML5 slide show) on PowerShow.com - id: 104ba1-ZDc1Z
On-Board Silicon Photonics-Based Transceivers With 1-Tb/s Capacity (2016)

Providing host Application-specific integrated circuit (ASIC) (e.g., microprocessors, switches, or field-programmable gate array (FPGAs)) with terabit per second optical transmission capabilities has emerged as a new requirement in exascale cloud data centers and high-performance computing. The combination of silicon photonics (Si-Phot) and 3-D interconnecting technologies stands as a unique solution for fulfilling this need while addressing the key factors of success that are more Gb/s/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , less pJ/bit, and less $/Gb/s. This paper is intended to present and evaluate several Si-Phot-based solutions for providing the host ASIC with 1-Tb/s optical transceivers. Two packaging architectures are proposed, making use of 3-D interconnecting building blocks, and motivated by the need for implementing a few hundreds of high-speed electrical interconnections. Models are given for each of the 3-D building blocks, and simulation of the overall electrical signal integrity is made for the two proposed transceiver architectures. In addition, using the capability of CMOS fabrication lines for producing low-cost transceiver chips (Si-Phot integrated circuits with their electronic ICs) and 3-D chip assemblies, it is also necessary to develop high-throughput/low-cost techniques for coupling the light from the chip to the fiber. One such technique will be presented.
New anastomotic gun for biofragmentable anastomotic ring in low anterior resection (1995)

Therefore, we believe biofragmentable ring rectal anastomosis is a safe and reliable alternative to other anastomotic methods in rectal surgery.
Lexical Priming: A New Theory of Words and Language (2005)

List of tables, diagrams and figures Acknowledgements Important Foreword 1. Collocation and Lexical Priming 2. Lexical Priming and Meaning 3. Lexical Priming and Grammar 4. Lexical Priming and Lexical Relation 5. Lexical Priming and Polysemy 6. Lexical Priming and Text: Two Claims 7. Lexical Priming and Text: A Third Claim 8. Lexical Priming and Grammatical Creativity 9. Lexical Priming and Other Kinds of Creativity 10. Some Theoretical and Practical Issues Bibliography.
Foreword (1995)

NAVIGATION is a quarterly journal published by the Institute of Navigation. The journal publishes original, peer-reviewed articles on all aspects of positioning, navigation, and timing. The journal also publishes selected technical notes and survey articles, as well as papers of exceptional quality drawn from the Institute’s conference proceedings.
The Role of Imaging and Navigation for Natural Orifice Translumenal Endoscopic Surgery (2009)

The safe realization and standardization of NOTES represents a real challenge that necessitates close and effective interdisciplinary collaboration of surgeon, technicians, informatics, and endoscopic and applied industries. Image-guided soft-tissue navigation may be very helpful to minimize the hazards of the technically challenging procedure.
Determination of Protein Synthesis In‐Vivo with 15 N‐Glycine Labeling and MALDI‐TOF Spectrum Analysis (2010)

Previously, the group has demonstrated the feasibility of determining in‐vivo protein synthesis by utilizing deuterated water labeling [1] and in‐vitro protein synthesis with 15 N‐glycine labeling [2]. The study is designed to give preliminary proof of concept that the 15 N‐glycine labeling can also be applied for in‐vivo protein synthesis determination. Two mice were fed 20 g of 15 N glycine/kg of chow for 7 days. The mice serum albumin was SDS‐PAGE purified, followed by in‐gel tryptic digestion, before MALDI‐TOF profiling. Mass spectra data for two specific peptide sequences with mass to charge (m/z) of 1479 and 1609 were analyzed for 15 N enrichment and fraction of new synthesis. For m/z =1479, average enrichment of 15N in the peptide was found to be 6.06% for mouse 1 and 6.10% for mouse 2, with fraction of new synthesis found to be 97.52% and 96.54% respectively. The 15 N enrichment for m/z =1609 was found to be 5.25% for mouse 1 and 6.31% for mouse 2, with fraction of new synthesis of 90.24% and 88.28% respectively. The mass spectral peaks of the heavier protein can be resolved from the natural protein by a mathematical algorithm. The capability of resolving overlapping spectra makes it possible to label proteins with lower enrichment of stable isotopes.
A Computational Study of the Raman Spectra of Large Polycyclic Aromatic Hydrocarbons:  Toward Molecularly Defined Subunits of Graphite (2002)

We present a quantum chemical investigation of the vibrational frequencies and Raman intensities of large polycyclic aromatic hydrocarbons (PAHs) as models for nanosized graphitic domains in carbon materials. The gradient corrected BLYP functional, in the framework of density functional theory, was employed to compute equilibrium structures, vibrational force fields, and Raman intensities. Molecules of different size (from 24 to 138 carbon atoms) and symmetry (D6h, D3h, D2h) were investigated. It is shown that the simulated Raman spectra compare well with the available experimental spectra. The analysis of Raman activities in terms of local contributions from internal coordinates shows that the PAHs can be grouped in essentially two classes related more strictly to their “benzenoid” character than to the shape of their periphery. The analysis of local contributions to polarizability derivatives combined with the shape of the molecular motion of the Raman active vibrations in the 1300 cm-1 region of PAHs supports the mechanism recently proposed by us to explain the appearance of the D band in disordered graphitic materials.
3-D Conformal Metasurfaces (2013)

This letter presents a method for mapping and fabricating metasurfaces on arbitrary 3-D surfaces. Metasurfaces are used for holographic leaky-wave antennas, reflectarray antennas, coatings for soft horn antennas, artificial magnetic conductors, high-impedance surfaces, frequency selective surfaces, electromagnetic band-gap structures, and surface-wave waveguides. They are typically fabricated as 2-D planar structures by printing a grid of metallic patches on a dielectric substrate, but for some applications, it is desirable to create a metasurface conformal to a 3-D surface. The methods presented here can be used with direct-write printing or with standard printed circuit board (PCB) techniques. The PCB method involves mapping the metasurface to a set of 2-D bands that are laminated to a 3-D substrate. As an example, a 3-D conformal, ellipsoidal, holographic, leaky-wave antenna was designed, fabricated, and measured.
OXIDATION OF PYRUVATE AND GLUCOSE BY OOCYTES OF THE MOUSE AND RHESUS MONKEY (1971)

Summary. Carbon dioxide formed by the mouse oocyte from glucose was 0·145 pmol/hr/oocyte, which is the same as the value previously found for unfertilized mouse ova. Carbon dioxide formed by the Rhesus monkey oocyte from pyruvate and glucose was 12·77 and 0·73 pmol/hr/oocyte, respectively. Pyruvate is probably a major energy source for all early mammalian embryos.
A Data Mining Approach for Cardiovascular Disease Diagnosis Using Heart Rate Variability and Images of Carotid Arteries (2016)

In this paper, we proposed not only an extraction methodology of multiple feature vectors from ultrasound images for carotid arteries (CAs) and heart rate variability (HRV) of electrocardiogram signal, but also a suitable and reliable prediction model useful in the diagnosis of cardiovascular disease (CVD). For inventing the multiple feature vectors, we extract a candidate feature vector through image processing and measurement of the thickness of carotid intima-media (IMT). As a complementary way, the linear and/or nonlinear feature vectors are also extracted from HRV, a main index for cardiac disorder. The significance of the multiple feature vectors is tested with several machine learning methods, namely Neural Networks, Support Vector Machine (SVM), Classification based on Multiple Association Rule (CMAR), Decision tree induction and Bayesian classifier. As a result, multiple feature vectors extracted from both CAs and HRV (CA+HRV) showed higher accuracy than the separative feature vectors of CAs and HRV. Furthermore, the SVM and CMAR showed about 89.51% and 89.46%, respectively, in terms of diagnosing accuracy rate after evaluating the diagnosis or prediction methods using the finally chosen multiple feature vectors. Therefore, the multiple feature vectors devised in this paper can be effective diagnostic indicators of CVD. In addition, the feature vector analysis and prediction techniques are expected to be helpful tools in the decisions of cardiologists.
Running the gauntlet: from peptide generation to antigen presentation by MHC class I (2011)

Major histocompatibility complex (MHC) class I molecules provide the molecular basis for the comprehensive surveillance of an organism by the cytotoxic arm of the adaptive immune system. To exert this function correctly, class I molecules must be loaded with peptide ligands of appropriate length, sequence and affinity that provide a rapidly updated and sufficiently comprehensive picture of the state of the cell. This is accomplished by a sophisticated cellular machinery using a blend of cellular house-keeping proteins and dedicated transporters, chaperones and peptidases. The last 10 years have seen substantial progress in our comprehension of this machinery. It seems now clear that a large proportion of MHC class I ligands are derived from short-lived products of the ribosomal apparatus, many of which correspond to defective proteins. Despite much effort to identify alternative proteolytic pathways, cytosolic production of epitopes still appears to depend almost entirely on the proteasome, while cytosolic aminopeptidases act mainly to limit antigen presentation. In contrast, clear evidence for a critical role of trimming peptidases residing in the endoplasmic reticulum has emerged. These enzymes play a role in responses against pathogens and are associated with autoimmune diseases, most notably ankylosing spondylitis. Much has also been learned about the intricate chaperone interactions in peptide-loading complexes, especially with respect to the structural role of tapasin-ERp57 conjugates and to the editing function of tapasin. In contrast, cross-presentation of exogenous antigens by MHC class I molecules still remains somewhat poorly understood and is likely to attract much research effort for years to come.
A [8,8'-μ-I-3-Co(1,2-C2B9H10)2] metallacarborane complex with a iodonium bridge. Evidence for a bromonium analogue (1984)

The [8,8'-μ-I-3-Co(1,2-C 2 B 9 H 10 ) 2 ] complex with a iodonium bridge between both dicarbollide ligands was prepared and its constitution was established by NMR methods. It behaves as a Lewis acid opening its bridge by the action of Lewis bases to form {8-I-8'-L-3-Co(1,2-C 2 B 9 H 10 ) 2 ] species. The less stable bromonium analogue was not isolated but its existence was confirmed by the reaction with Lewis bases affording the [8-Br-8'-L-3-Co(1,2-C 2 B 9 H 10 ) 2 ]derivatives.
High-resolution, High-speed, Three-dimensional Video Imaging with Digital Fringe Projection Techniques (2013)

Digital fringe projection (DFP) techniques provide dense 3D measurements of dynamically changing surfaces. Like the human eyes and brain, DFP uses triangulation between matching points in two views of the same scene at different angles to compute depth. However, unlike a stereo-based method, DFP uses a digital video projector to replace one of the cameras(1). The projector rapidly projects a known sinusoidal pattern onto the subject, and the surface of the subject distorts these patterns in the camera's field of view. Three distorted patterns (fringe images) from the camera can be used to compute the depth using triangulation. Unlike other 3D measurement methods, DFP techniques lead to systems that tend to be faster, lower in equipment cost, more flexible, and easier to develop. DFP systems can also achieve the same measurement resolution as the camera. For this reason, DFP and other digital structured light techniques have recently been the focus of intense research (as summarized in(1-5)). Taking advantage of DFP, the graphics processing unit, and optimized algorithms, we have developed a system capable of 30 Hz 3D video data acquisition, reconstruction, and display for over 300,000 measurement points per frame(6,7). Binary defocusing DFP methods can achieve even greater speeds(8). Diverse applications can benefit from DFP techniques. Our collaborators have used our systems for facial function analysis(9), facial animation(10), cardiac mechanics studies(11), and fluid surface measurements, but many other potential applications exist. This video will teach the fundamentals of DFP techniques and illustrate the design and operation of a binary defocusing DFP system.
Stabilizer‐Guided Inhibition of Protein–Protein Interactions (2015)

The discovery of novel protein-protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated by either inhibitor or stabilizer compounds, which target different though proximal regions of the protein interface. In principle, protein-stabilizer complexes can guide the design of PPI inhibitors (and vice versa). In the present work, we combine X-ray crystallographic data from both stabilizer and inhibitor co-crystal complexes of the adapter protein 14-3-3 to characterize, down to the atomic scale, inhibitors of the 14-3-3/Tau PPI, a potential drug target to treat Alzheimer's disease. The most potent compound notably inhibited the binding of phosphorylated full-length Tau to 14-3-3 according to NMR spectroscopy studies. Our work sets a precedent for the rational design of PPI inhibitors guided by PPI stabilizer-protein complexes while potentially enabling access to new synthetically tractable stabilizers of 14-3-3 and other PPIs.
ATMOSPHERIC OZONE AT WASHINGTON, D. C. (1950)

Total atmospheric ozone measurements at Washington, D. C., for the period February 18, 1948, through March 9, 1950, are tabulated and described. The usual annual variation is found. The average amount of ozone observed for the 2 years is somewhat low for 39° N. latitude. Ozone departures from normal in relation to surface low and high pressure systems are analyzed. The distribution around Lows agrees quite well with most other analyses. Around Highs the distribution is poorly defined, and is considerably different from results at other geographical areas. Correlations of ozone with temperatures at the 500-mb. and 100-mb. levels are examined. The correlation coefficients vary regularly from month to month, and there is a suggestion that their highest absolute values occur in some spring and winter months, and that the lowest absolute values occur in summer and early autumn. Two possible explanations of this variation are discussed, namely, (1) the annual cycle of the variability of ozone and of temperature, and (2) the annual change of the winds above 18 km.
Synergy of multi-modelling for process control (2018)

In this paper a multi-modelling experiment is presented through which we have studied the possibilities of manufacturing process control supported by different digital simulation models. The main pillar of the study is a real, operating, research and demonstration cyber-physical production system which is detailed in the study. Our digital twin of the system in question includes two different virtual models; an agent-based model endowed with the ability of error handling, and a discrete-event simulation-based model for forecasting and supporting the error handling routine with evaluating bids. The experiment includes typical manufacturing processes with machine failures, which should be detected and recognized to invoke both simulations for re-forecast and error management.
Skilled Care Requirements for Elderly Patients After Coronary Artery Bypass Grafting (2005)

Older patients are more likely to be admitted to a SNF, be readmitted to an acute-care hospital, and have longer institutional stays after CABG. When balancing the risks and benefits of CABG, physicians, patients, families, and policy-makers need to carefully consider the likelihood of follow-up institutional care in elderly patients.
Design Of A Silicon Microphone With Differential Read-out Of A Sealed Double Parallel-plate Capacitor (2005)

SUMMARY A new design of a sealed capacitive microphone with differential capacitive read-out and high sensitivity is presented. The design allows for higher electrical bias fields and thereby higher sensitivities compared to ordinary capacitive microphones. The bias field can be further increased if force balancing is used which is very simple to implement with this design. To avoid too high bias voltages the air gap is reduced. The design is based on analytical modelling and finite element calculations.
Supporting the process of personal change in diabetes self-management during group education: lessons learned from audio recorded sessions (2016)

Objective: The objective of this paper is to describe the education process during a pilot group education program for people with type 2 diabetes in Belgium. The specific aims were to explore the personal change processes during the group sessions and to identify supporting and hindering elements in/for these processes. Methods: We used a qualitative research approach from a constructivist perspective to study the education process during the group sessions. Two theoretical frames (trans-theoretical model and Strengths-Weaknesses-Opportunities-Threats (SWOT)-matrix) were used to document changes in (motivation towards) self-management and to explore how the program influenced this change process. Results: Supporting elements for personal change were identified and comprise: an empowerment attitude and tailored approach focusing on expectations and needs, the goal-setting process (mainly objectivizing current behaviour), peer support and using social support networks and community activities. Hindering elements include: providing extensive and detailed information not related to individual goals, the optional nature of the program in relation to active participation, too much focus on the expert role of the coaches and contextual barriers like an unsupportive environment/GP and co morbidity. Conclusions: Based on the audio-recordings of the group sessions, we can conclude that many people did change their self management behaviour (or started reflecting on it) while following the program. We were able to document concrete changes people made but we could only identify a few links between specific program components and specific changes processes ( e.g. pedometer, nutritional information). However, the SWOT analysis provided interesting knowledge that can inform future programs and support educators during group sessions. First, a flexible approach may be preferable to stage-specific approaches. In addition, the analysis drew attention to the fact that not everybody needs to change behaviour. What a program should aim for, is that everyone starts reflecting and subsequently takes an informed decision to change or not. Finally, diabetes educators should find a balance between their three different roles (expert, coach, and moderator) and should be provided with professional support.
A Comparison of the Value of Clarase, Penicillinase, and Cysteine Hydrochloride in Revealing the Presence of Contaminating Organisms in Preparations of Penicillin (1945)

Summary Under the experimental conditions used clarase appeared to be more satisfactory for use in the routine testing of sterility of solutions of penicillin than penicillinase or cysteine hydrochloride. Purified penicillinase was only slightly less effective than clarase and, because of the ease of sterilization, it might prove to be the better agent if obtainable in large amounts. While cysteine is capable, under certain conditions, of destroying quickly large amounts of penicillin inconstant results may be obtained because of its instability. Another disadvantage in the use of cysteine is its bacteriostatic action against certain organisms in a concentration necessary for inactivation of penicillin.