gebhart/patrepeval huggingface dataset:
Acidity, Electric Conductivity, Dissolved Oxygen Total Dissolved Solid and Salinity Profiles of Marine Water in Gaza: Influence of Wastewater Discharge (2021)

Effects of wastewater discharge on the coastal area in Gaza strip Palestine are not fully investigated. This study investigated the effect wastewater discharge of the physical and chemical properties of marine water in the coastal area over a period of 2 year. Sea water and sediment samples were collected from about 20 different sites. The water and the sediments were collected wastewater/sea water mixing zone at depth 0, 2.5 and 5 m water column depth at a direct wastewater discharging pipe line from different location and similarly from other locations. Water temperature T, electric conductivity (EC), dissolved oxygen (DO), pH, total dissolved solid (TDS) and salinity were determined for water samples using field equipment such as pH-meter, DO meter, TDS-/ and EC-meter. On the other hand, NO3-, SO42-, PO43- were determined in the laboratory using chemical methods, details are described in materials and method section. Results showed average and standard deviation of T, EC, DO, pH, TDS and salinity were 22.02°C ± 4.1°C, EC: 58.41 ± 4.8 ms/cm; DO: 6.96 ± 1.8 mg/L; pH: 7.69 ± 0.37; TDS: 30.51 ± 3.29 and salinity 4.39 ± 0.12 (%); whereas, average and standard deviation of NO3-: were 299.8 ± 204.1 mg/L; SO42-, 5736.9 ± 817.1; and PO43-: 164.35 ± 120.7 mg/L. The measured values indicate significant differences due to high value of standard deviation of some measured parameters. This indicates the influence of wastewater discharge in sea water as shown inside the manuscript in the appropriate section. The study recommends efficient treatment of wastewater and reuses it for agricultural purposes instead of discharging it in sea.
Training Restricted Boltzmann Machines via the Thouless-Anderson-Palmer Free Energy (2015)

Restricted Boltzmann machines are undirected neural networks which have been shown to be effective in many applications, including serving as initializations for training deep multi-layer neural networks. One of the main reasons for their success is the existence of efficient and practical stochastic algorithms, such as contrastive divergence, for unsupervised training. We propose an alternative deterministic iterative procedure based on an improved mean field method from statistical physics known as the Thouless-Anderson-Palmer approach. We demonstrate that our algorithm provides performance equal to, and sometimes superior to, persistent contrastive divergence, while also providing a clear and easy to evaluate objective function. We believe that this strategy can be easily generalized to other models as well as to more accurate higher-order approximations, paving the way for systematic improvements in training Boltzmann machines with hidden units.
Supplementary Table 1 from <i>Seizure 6-Like</i> (<i>SEZ6L</i>) Gene and Risk for Lung Cancer (2023)

Supplementary Table 1 from &lt;i&gt;Seizure 6-Like&lt;/i&gt; (&lt;i&gt;SEZ6L&lt;/i&gt;) Gene and Risk for Lung Cancer
Early scintographic diagnosis of bone stress and fractures in athletic adolescents. (1982)

A study of radionuclide bone scintigraphy in adolescents was conducted to evaluate the pattern of stress-related abnormalities and their correlation with both symptoms and roentgenography. In 26 episodes of stress-related abnormal scintigraphy, 12 (46%) had a multifocal pattern of abnormalities. Forty foci were identified by scintigraphy, with 11 (28%) exhibiting abnormal roentgenograms. These multiple abnormalities were frequently unsuspected clinically, and studies limited to symptomatic areas would have failed to detect them. It is recommended that patients with stress-related symptoms be screened utilizing radionuclide bone scintigraphy to facilitate the early detection of abnormalities in bone prior to the development of cortical disruption, thereby preventing increased morbidity and possible disabling sequelae.
Alleviation of Chronic Cancer Pain by Adrenal Medullary Transplants in the Spinal Subarachnoid Space (1992)

This article has no abstract.
<title>Clock synchronization in software MPEG-2 decoder</title> (1997)

A novel design to the problem of clock synchronization in software MPEG-2 decoders is presented. A software MPEG decoder is attractive in terms of cost and performance. However a software decoder is prone to timing uncertainty and delay jitters. By a clever use of adaptive filtering and sub sampling of time stamps, a frequency locked loop can be designed to deliver almost instantaneous capture of the unknown encoder clock frequency and with high tolerance to delay jitter. The exact analysis of the system is complex. By invoking suitable approximations, a complete design methodology is derived. Computer simulations verify the design approach illustrated.
TRIGGERED STAR FORMATION AND THE CREATION OF THE SUPERGIANT H I SHELL IN IC 2574 (2009)

Based on deep imaging from the Advanced Camera for Surveys aboard the Hubble Space Telescope (HST), we present new evidence that stellar feedback created a ~1 kpc supergiant H I shell (SGS) and triggered star formation (SF) around its rim in the M81 Group dwarf irregular galaxy IC 2574. Using photometry of the resolved stars from the HST images, we measure the star formation history of a region including the SGS, focusing on the past 500 Myr, and employ the unique properties of blue helium-burning stars to create a movie of SF in the SGS. We find two significant episodes of SF inside the SGS from 200-300 Myr and ~25 Myr ago. Comparing the timing of the SF events to the dynamic age of the SGS and the energetics from the H I and SF, we find compelling evidence that stellar feedback is responsible for creating the SGS and triggering secondary SF around its rim.
Cellular Immunotherapy for High Grade Gliomas: Mathematical Analysis Deriving Efficacious Infusion Rates Based on Patient Requirements (2010)

To date, no effective cure has been found for high grade malignant glioma (HGG), current median survival for HGG patients under treatment ranging from 18 months (grade IV) to 5 years (grade III). Recently, T cell therapy for HGG has been suggested as a promising avenue for treating such resistant tumors, but clinical outcome has not been conclusive. For studying this new therapy option, a mathematical model for tumor–T cell interactions was developed, where tumor immune response was modeled by six coupled ordinary differential equations describing tumor cells, T cells, and their respective secreted cytokines and immune mediating receptors. Here we mathematically analyze the model in an untreated case and under T cell immunotherapy. For both settings we classify steady states, determine stability properties, and explore the global behavior of the model. Analysis suggests that in untreated patients, the system always converges to a steady state of a large tumor mass. An increase in the patient's pro-inflammatory activity only marginally reduces tumor load at steady state. This result suggests that the patient's own immune system is never sufficient for eliminating HGG. In contrast, infusion of T cells above a certain level, $S_{\min}$, renders a curative tumor-free steady state locally asymptotically stable. When the infusion rate is increased above a higher threshold, $S_{\max}$, this steady state becomes globally stable, providing a cure from any initial state of the system. These thresholds, as well as the infusion time required for tumor elimination for different doses, are computed explicitly, and can be personalized using patient-specific parameters. Our results suggest that reduction of tumor load and even tumor elimination can be achieved, either by significantly encouraging the endogenous immune response or by T cell infusion. This work provides an insight and practical guidelines for improving the efficacy of brain cancer immunotherapy by T cell infusion, which should be further studied clinically.
Structural and electrochemical characterization of BaCe0.7Zr0.2Y0.05Zn0.05O3as an electrolyte for SOFC-H (2016)

As a potential electrolyte for proton-conducting solid oxide fuel cells (SOFC-Hs) and to get better protonic conductivity and stability, zinc doped BCZY material has been found to be promising. In this study, we report a new composition of proton conductors BaCe0.7Zr0.2Y0.05Zn0.05O3 (BCZYZn5) which was investigated using XRD, SEM and conductivity measurements. Rietveld refinement of the XRD data revel a cubic perovskite structure with Pm-3m space group. BaCe0.7Zr0.2Y0.05Zn0.05O3 shows cell parameter a = 4.3452(9) Å. Scanning electron microscopy images shows that the grain sizes are large and compact which gives the sample high density and good protonic conductivity. The total conductivity in wet atmosphere is significantly higher than that of dry condition and the conductivity was found to be 0.276 × 10-3 Scm-1 and 0.204 × 10-3 Scm-1 at 600°C in wet and dry Ar, respectively. This study indicated that perovskite electrolyte BCZYZn5 is a promising material for the next generation intermediate temperature solid oxide fuel cells (IT-SOFCs).
Abnormal Awake Respiratory Patterns Are Common in Chronic Heart Failure and May Prevent Evaluation of Autonomic Tone by Measures of Heart Rate Variability (1997)

Breathing disorders are surprisingly common in awake patients with poor left ventricular function and produce large VLF oscillations in heart rate variability. If measures of heart rate variability are used for prognostic purposes during both short-term and long-term recordings, the confounding effects of variable respiratory patterns should be excluded. Respiratory rehabilitation might help control potentially hazardous surges in sympathetic tone.
Chronic lymphocytic leukemia: planning for an aging population (2010)

Chronic lymphocytic leukemia (CLL) remains incurable, but over the past decade there have been major advances in the understanding of the pathophysiology of CLL and in the treatment of this disease. This has led to greatly increased response rates and durations of response, as well as improved survival. CLL is a disease of the elderly and not all patients are eligible for the aggressive upfront chemoimmunotherapy regimens that are resulting in improved response rates and survival, so what is the optimal treatment approach for more frail elderly patients? It is highly likely that our treatment approaches will continue to evolve as the results of ongoing clinical trials are released. The age range of patients involved in clinical trials is not representative of this disease, and more research is required in patients who are representative of the majority of CLL patients seen in practice before we will see outcome improvements in these more elderly and often more frail patient populations.
Self-Regenerating Fiber-Optic Sensors (1995)

Monitoring the level of environmental contaminants demands continuous and accurate data sometimes on several analytes simultaneously. Conventionally, contaminant levels are determined using techniques such as gas chromatography, mass-spectroscopy, high performance liquid chromatography or a combination thereof. A more recent development in environmental sensing is the use of immunoanalysis. Despite recent developments, these techniques are discontinuous and labor intensive. In this paper we discuss the use of fiber-optics in combination with immunoanalysis using two alternative methods to provide continuous sensing: first, based on a combination of antibodies with high binding constants and passive delivery of reagents and second, based on fast off-rate antibodies. These techniques allow for continuous analysis of environmental contaminants. We further introduce the concept of using imaging fiber bundles to provide spatial resolution of multiple reagents. These fibers can be used in combination with degradable polymers for continuous delivery of reagents or as substrates for the preparation of immunosensor arrays with multiple cross reactive antibodies.
Gut Microbiome as Target for Innovative Strategies Against Food Allergy (2019)

The dramatic increase in food allergy prevalence and severity globally requires effective strategies. Food allergy derives from a defect in immune tolerance mechanisms. Immune tolerance is modulated by gut microbiota function and structure, and microbiome alterations (dysbiosis) have a pivotal role in the development of food allergy. Environmental factors, including a low-fiber/high-fat diet, cesarean delivery, antiseptic agents, lack of breastfeeding, and drugs can induce gut microbiome dysbiosis, and have been associated with food allergy. New experimental tools and technologies have provided information regarding the role of metabolites generated from dietary nutrients and selected probiotic strains that could act on immune tolerance mechanisms. The mechanisms are multiple and still not completely defined. Increasing evidence has provided useful information on optimal bacterial species/strains, dosage, and timing for intervention. The increased knowledge of the crucial role played by nutrients and gut microbiota-derived metabolites is opening the way to a post-biotic approach in the stimulation of immune tolerance through epigenetic regulation. This review focused on the potential role of gut microbiome as the target for innovative strategies against food allergy.
3-(2-hydroxyphenyl)catechol as substrate for proximal meta ring cleavage in dibenzofuran degradation by Brevibacterium sp. strain DPO 1361 (1991)

Brevibacterium sp. strain DPO 1361 oxygenates dibenzofuran in the unusual angular position. The 3-(2-hydroxyphenyl)catechol thus generated is subject to meta ring cleavage in the proximal position, yielding 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-2,4-hexadienoic acid, which is hydrolyzed to 2-oxo-4-pentenoate and salicylate by 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid hydrolase. The proximal mode of ring cleavage is definitely established by isolation and unequivocal structural characterization of a cyclization product of 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-2,4-hexadienoic acid, i.e., 3-(chroman-4-on-2-yl)pyruvate.
Measurement by antilocalization of interactions between InAs surface electrons and magnetic surface species (2012)

We show that antilocalization measurements can be used to experimentally study the interactions between InAs surface electrons and local moments of the rare earth ions Sm3+, Gd3+, and Ho3+ on the surface. Magnetic spin-flip scattering and spin-orbit scattering of the accumulation layer electrons are affected by the proximity of the rare earth ions. The spin-flip rate carries information about magnetic interactions. Within the temperature range studied, Sm3+ and Gd3+ yield temperature-independent electron spin-flip rates in proportion to their magnetic moments. In proximity to Ho3+ the InAs electrons however show a spin-flip rate increasing with temperature. We interpret the spin-flip rate due to Ho3+ as resulting from transitions between closely spaced energy levels of the ion on the surface. The experiments also show that the strength of spin-orbit interaction can be modified by the surface species.
Ultrasonic Properties of a Nematic Sidechain Polysiloxane in the 100 MHz—1 GHz Range (1993)

Abstract Liquid crystalline polymers exhibit a number of properties, e.g. the viscoelastic behaviour in the ultrasonic range, which are neither observed in low molecular weight liquid crystals nor in isotropic polymers. Acoustic waves in the 100 MHz‐1 GHz range have been generated in a nematic liquid single crystal sidechain polysiloxane elastomer through impulsive stimulated thermal scattering and their propagation characteristics have been studied. The experiments reveal a dispersion step for the speed of sound and a strong anisotropy for the acoustic attenuation constant in the investigated frequency range consistent with a recently proposed hydrodynamic model of a coupling of the elasticity to the nematic order parameter in this class of substances.
Fluid and electrolyte resuscitation of the thermally injured patient (1983)

Abstract Fluid and electrolyte management of thermal injury continues to undergo evolution. The goal of resuscitation is optimal maintenance of vital organ function, and during the first 24 hours after injury, resuscitation is best accomplished with isotonic balanced salt solution. Colloid‐containing solutions do not offer any advantage and may be deleterious. In the second 24 hours, fluid replacement should account for free water losses, maintaining serum sodium at 140 mEq/L. The use of colloid‐containing solution may be of benefit during this time period after capillary integrity is reestablished. Several formulae are available for initial guides, although clinical evaluation of adequate intravascular expansion is necessary. This is best accomplished using urine output as an indication of renal perfusion. Special attention is necessary in the resuscitation of children, the elderly, patients with inhalation or electrical injuries, and patients having a delay in initial resuscitation.
Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome (2023)

Substance use disorders are associated with disruptions in sleep and circadian rhythms that persist during abstinence and may contribute to relapse risk. Repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (NAc), a brain region central to reward and motivation. Previous studies have identified rhythm alterations in the transcriptome of the NAc and other brain regions following the administration of psychostimulants or opioids. However, little is known about the impact of substance use on the diurnal rhythms of the proteome in the NAc. We used liquid chromatography coupled to tandem mass spectrometry-based quantitative proteomics, along with a data-independent acquisition analysis pipeline, to investigate the effects of cocaine or morphine administration on diurnal rhythms of proteome in the mouse NAc. Overall, our data reveal cocaine and morphine differentially alter diurnal rhythms of the proteome in the NAc, with largely independent differentially expressed proteins dependent on time-of-day. Pathways enriched from cocaine altered protein rhythms were primarily associated with glucocorticoid signaling and metabolism, whereas morphine was associated with neuroinflammation. Collectively, these findings are the first to characterize the diurnal regulation of the NAc proteome and demonstrate a novel relationship between the phase-dependent regulation of protein expression and the differential effects of cocaine and morphine on the NAc proteome. The proteomics data in this study are available via ProteomeXchange with identifier PXD042043.
Molecular Cloning of Mouse Peptidylarginine Deiminase, and Its Possible Isozyme cDNAs (1991)

Journal Article Molecular Cloning of Mouse Peptidylarginine Deiminase, and Its Possible Isozyme cDNAs Get access Mamoru Tsuchida, Mamoru Tsuchida Laboratory of Biochemistry, Faculty of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300–03, Japan Search for other works by this author on: Oxford Academic Google Scholar Naoko Minami, Naoko Minami Laboratory of Biochemistry, Faculty of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300–03, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroaki Tsujimoto, Hiroaki Tsujimoto Laboratory of Biochemistry, Faculty of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300–03, Japan Search for other works by this author on: Oxford Academic Google Scholar Chikafusa Fukazawa, Chikafusa Fukazawa Genetic Engineering Laboratory, Division of Applied Microbiology, National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Hidenari Takahara, Hidenari Takahara Laboratory of Biochemistry, Faculty of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300–03, Japan Search for other works by this author on: Oxford Academic Google Scholar Kiyoshi Sugawara Kiyoshi Sugawara Laboratory of Biochemistry, Faculty of Agriculture, Ibaraki University, Ami-machi, Inashiki-gun, Ibaraki 300–03, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 55, Issue 1, 1 January 1991, Pages 295–297, https://doi.org/10.1080/00021369.1991.10870549 Published: 01 January 1991 Article history Received: 12 October 1990 Published: 01 January 1991
Understanding Tunneling Experiments on Metallic Nanoparticles: Single-Particle versus Many-Body Phenomena (2002)

We present tight-binding calculations of the electronic states of nanoscopic aluminum particles coated with aluminum oxide. We find that the single-electron energy levels in the neighborhood of the Fermi energy of the particle exhibit clustering, even in the presence of strong disorder at the interface. Our results indicate that the bunching of levels observed experimentally in such particles is influenced strongly by the microscopic details of the structure of the individual sample as well as by many-electron effects.
Basophil priming by neurotrophic factors. Activation through the trk receptor (1996)

There is increasing evidence that nerve growth factor (NGF) acts on cells of the immune system, apart from its neurotrophic effects. In human basophils, NGF potentiates mediator release and primes the cells to produce leukotriene C4 in response to C5a. It is, however, unknown whether other homologous neurotrophins also act outside the nervous system, and whether activation of basophils by NGF requires interaction with trk tyrosine kinase receptors, the low affinity NGF receptor (LNGFR), or both. A triple mutant NGF designed to interrupt binding to the LNGFR was found to activate basophils with equal efficacy as wild-type NGF, demonstrating that the LNGFR is not necessary. Despite a 10 times lower potency of mutant NGF, no LNGFR expression was detected by FACS analysis. Brain-derived neurotrophic factor, which interacts with trkB, was inactive at concentrations up to 1000 ng/ml (> 30,000-fold lower potency than NGF), while neurotrophin-3, which is thought to interact with trkC, trkB, and more weakly with trk, induced a threshold effect at 300 ng/ml (approximately 10,000-fold lower potency), demonstrating that 1) the LNGFR cannot deliver a direct signal; and 2) basophils do not express functional trkB and trkC receptors. In agreement with the functional data, basophils (in contrast to other granulocyte types) expressed mRNA for trk, but not trkB or trkC, and no or minimal mRNA for LNGFR. These data demonstrate that human blood basophils express functional trk receptors that do not require the participation of LNGFR, and that, among the neurotrophin family, NGF is unique in priming basophils.