gebhart/patrepeval huggingface dataset:
INBREEDING AND PREREPRODUCTIVE MORTALITY IN THE OLD ORDER AMISH. I. GENEALOGIC EPIDEMIOLOGY OF INBREEDING (1987)

Epidemiologic patterns of inbreeding in the Old Order Amish were investigated using a unique genealogic registry of Lancaster County, Pennsylvania, Amish that contains information on 8,163 marriages, dating back to the time of the pioneer migrants in the 1700s and spanning more than 10 generations. The kinship coefficient for each marriage was computed using the path method of tracing common ancestors in the multigenerational pedigrees. Because of extensive genealogic connections, mean kinship coefficients and the proportion of related marriages have increased significantly over time, from 0.004 and 37%, respectively, for marriages before 1850 to 0.012 and 98%, respectively, for marriages after 1950. Demographic factors related to higher kinship levels include young age at marriage, large sibship size for both husband and wife, husband being a farmer, and marriages occurring in the marriage season (November or December). The rise in inbreeding levels in the Amish over time can be uniquely contrasted with the decline in inbreeding in most areas of the world. Furthermore, because some of the demographic factors related to high inbreeding levels may be associated with levels of mortality, such factors have to be taken into account when studying the effects of inbreeding on mortality in the Amish. This study uses an epidemiologic approach to the evaluation of inbreeding patterns in a population over time.
Does Eosinophilic Inflammation Affect the Outcome of Endoscopic Sinus Surgery in Chronic Rhinosinusitis in Koreans? (2013)

The results suggest that eosinophilic inflammation in CRS may not be related to the surgical outcome in Koreans.
PhD in Electrical and Information Engineering in Europe: Towards a harmonization including LifeLong Learning (2012)

In the frame of the thematic networks devoted to the development of LifeLong Learning (LLL) in Europe, the ELLEIEC project, more especially focused on the Electrical and Information Engineering, the situation of PhD students in Europe was analyzed with the goal to highlight the differences that remain in Europe about the delivery of diploma and the adequacy of the academic institution regulations to the prior learning validation at this level. A questionnaire submitted to all the members of this network allowed an overview on 23 European countries was obtained. This paper tries to highlight the several aspects of the status and proposes recommendations in order to make easier the mobility and exchange in Europe at PhD level as well the recognition of prior studies to make suitable the LLL. On the base of the analysis, some recommendations within the global approach of Higher Education in Europe are emitted.
Correction to Carbon Dioxide Separation from Nitrogen/Hydrogen Mixtures over Activated Carbon Beads: Adsorption Isotherms and Breakthrough Studies (2015)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Carbon Dioxide Separation from Nitrogen/Hydrogen Mixtures over Activated Carbon Beads: Adsorption Isotherms and Breakthrough StudiesSimon J. Caldwell, Bushra Al-Duri, Nannan Sun, Cheng-gong Sun, Hao Liu, Colin E. Snape, Kaixi Li, and Joseph Wood*Cite this: Energy Fuels 2015, 29, 7, 4666Publication Date (Web):June 25, 2015Publication History Published online25 June 2015Published inissue 16 July 2015https://pubs.acs.org/doi/10.1021/acs.energyfuels.5b01372https://doi.org/10.1021/acs.energyfuels.5b01372correctionACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views504Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (106 KB) Get e-Alertsclose Get e-Alerts
Designer TGFβ Superfamily Ligands with Diversified Functionality (2011)

Transforming Growth Factor -beta (TGFb) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins (BMPs), are excellent targets for protein-based therapeutics because of their pervasiveness in numerous developmental and cellular processes. We developed a strategy termed RASCH (Random Assembly of Segmental Chimera and Heteromer), to engineer chemically-refoldable TGFb superfamily ligands with unique signaling properties. One of these engineered ligands, AB208, created from Activin-bA and BMP-2 sequences, exhibits the refolding characteristics of BMP-2 while possessing Activin-like signaling attributes. Further, we find several additional ligands, AB204, AB211, and AB215, which initiate the intracellular Smad1-mediated signaling pathways more strongly than BMP-2 but show no sensitivity to the natural BMP antagonist Noggin unlike natural BMP-2. In another design, incorporation of a short N-terminal segment from BMP-2 was sufficient to enable chemical refolding of BMP-9, without which was never produced nor refolded. Our studies show that the RASCH strategy enables us to expand the functional repertoire of TGFb superfamily ligands through development of novel chimeric TGFb ligands with diverse biological and clinical values.
A STUDY ON THE BOOLEAN ALGBRAS IN THE FRAENKEL-MOSTOWSKI TOPOS (2000)

The purpose of the paper is to show that in the Fraenkel-Mostowski topos, the category of the Boolean algebras has enough injectives.
Commentary: Vitamin D and colorectal cancer—twenty-five years later (2005)

Gorham ED, Garland FC, Garland CF. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 1990;19:820–24. 4 Garland F, Garland C, Gorham E, Young J Jr. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 1990;19:614–22. 5 Lefkowitz ES, Garland CF. Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol 1994;23: 1133–36. 6 Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1985;1:307–09. 7 Garland C, Comstock G, Garland F, Helsing K, Shaw E, Gorham E. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 1989;2:1176–78. 8 Garland C, Garland F, Gorham E. Rising trends in melanoma: a hypothesis concerning sunscreen effectiveness. Ann Epidemiol 1993; 3:103–10. 9 Garland C, Garland F, Gorham E. Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol 2003;13:395–404. 10 Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002;94:1867–75. 11 Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003;88:296–307. 12 Feskanich D, Ma J, Fuchs CS et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 2004;13:1502–08. 13 Bareis P, Bises G, Bischof MG, Cross HS, Peterlik M. 25-hydroxyvitamin D metabolism in human colon cancer cells during tumor progression. Biochem Biophys Res Commun 2001;285:1012–17. 14 Giovannucci E. The Goodman Lecture: The role of vitamin D in cancer incidence and mortality. In Annual Meeting of the American Association for Cancer Research, 2005. Anaheim CA: American Association for Cancer Research, 2005.
Benzophenone and Fimetarone Derivatives from the Coprophilous Fungus Delitschia confertaspora (2017)

Studies of the genome-sequenced, flutimide-producing coprophilous fungus Delitschia confertaspora (ATCC 74209), originally obtained from a sample of rock hyrax (Procavia capensis) dung collected in Namibia, led to the discovery of three new highly aromatic natural products named delicoferones A-B (1-2) and fimetarone B (3). The new benzophenone derivatives 1 and 2 have a somewhat unusual skeleton that incorporates three aromatic rings linked via two ketone carbonyl groups, while 3 contains a spiro[chroman-3,7'-isochromene]-4,6'(8'H) skeleton reported only once previously. The structures of these compounds were assigned mainly by analysis of 2D NMR and HRESITOFMS data.
Intracorporeal Anastomosis in Laparoscopic Gastric Cancer Surgery (2012)

Laparoscopic gastrectomy has become widely used as a minimally invasive technique for the treatment of gastric cancer. When it was first introduced, most surgeons preferred a laparoscopic-assisted approach with a minilaparotomy rather than a totally laparoscopic procedure because of the technical challenges of achieving an intracorporeal anastomosis. Recently, with improved skills and instruments, several surgeons have reported the safety and feasibility of a totally laparoscopic gastrectomy with intracorporeal anastomosis. This review describes the recent technical advances in intracorporeal anastomoses using circular and linear staplers that allow for totally laparoscopic distal, total, and proximal gastrectomies. Data that demonstrate advantages in early surgical outcomes of a total laparoscopic method compared to laparoscopic-assisted operations are also discussed.
The Simon Nitinol Filter: Evaluation by MR and Ultrasound (1992)

In this prospective blinded study of inferior vena caval (IVC) patency, 18 patients underwent 25 duplex ultrasound (US) and magnetic resonance (MR) angiography examinations over an eight-month period following Simon nitinol filter placement. Clinical examination for lower extremity venous stasis and plain abdominal radiography were also performed. Twenty-three of 24 MR examinations and 11 of 24 US examinations were judged technically adequate by the blinded observers. One technically adequate US exam was false positive for intraluminal caval thrombus. Thirteen technically inadequate US examinations missed 3 complete caval occlusions and 2 partial occlusions. MR identified all patients with complete or partial caval occlusion. The authors conclude that duplex US reliably confirms IVC patency only when strict criteria for technical adequacy and interpretation are met (good visualization of filter and IVC above and below filter). MR, although expensive, more reliably identifies nonoccluding intraluminal thrombus and caval occlusion. It should be the noninvasive study of choice in symptomatic patients with venous stasis and patients with recurrent pulmonary emboli.
The Never-Ending Quest: Search Engine Relevance. (2000)

Dans le domaine de la recherche d'information, comment s'entendre sur la notion de pertinence ? Les variations dans la formulation meme de la requete induisent des resultats differents. Face a la masse enorme et a la diversite des types d'informations disponibles sur le Web, les moteurs de recherche ont developpe des techniques pour ameliorer le niveau d'interet des resultats de recherche. L'article examine les obstacles a la pertinence et les tentatives des moteurs de recherche pour les contourner. Mais trouver les reponses les plus pointues risque de demeurer un art difficile pour quelque temps encore...
20 year-follow up of mitral stenosis patients after percutaneous valve commissurotomy: moderate disease of other valves as predictor for re-intervention (2022)

Abstract Background Percutaneous valve commissurotomy (PMC) is a viable alternative to mitral valve (MV) surgery in the treatment of patients with clinically significant mitral stenosis (MS). About 40% of patients treated with PMC will require at least one reintervention (either PMC or MVS) along time. Purpose To evaluate the long-term results of PMC in patients with rheumatic MS. Methods We retrospectively analysed all consecutive patients between 1991 and 2008 with clinically significant rheumatic MS undergoing PMC. Clinical and echocardiographic data were collected at baseline and during early and long-term follow-up. MACE was a composite of adverse events defined as all-cause mortality, MV re-intervention or cardiovascular hospitalization. Results A total of 124 patients were enrolled: 108 (87%) were female, with a mean age at the time of PMC of 46±11 years. At baseline, 34% patients were in NYHA class ≥ III and 81% had a Wilkins score ≤8; all patients had preserved biventricular systolic function and 83% presented pulmonary hypertension. Regarding associated valve disease, 46 patients had mild tricuspid regurgitation (TR), 19 mild aortic regurgitation (AR), 14 moderate IT and 5 moderated AR. Most of the procedures were successful (91%) and without complications (94%), with median improvement in MV area of 0.9 cm2 (IQR 0.5) and median reductions in mean transmitral gradient (MTG) of 6 mmHg (IQR 6) and in pulmonary artery systolic pressure (PASP) of 8 mmHg (IQR 10) early after PMC. During the mean follow-up of 20±6 years, 52 (42%) of patients had MV re-intervention (86% surgery and 14% re-PMC), 37 (30%) were hospitalized and 30 (24%) died. Concerning time-to-event analysis, approximately 80% of patients kept MACE-free after 10 years; after 30 years, more than 20% continued MACE-uneventful, approximately 50% were alive and about 45% were free from re-intervention. Considering patients submitted to surgical re-intervention, 9 underwent MV valvuloplasty and the others MV replacement with mechanical (32) or biological prothesis (11). At the same procedure, 23 patients were submitted to tricuspid annuloplasty, 9 to other valve replacement and one to coronary artery bypass graft. Using Cox regression, we found that the presence of moderate disease of other valves at PMC time was associated with a 2.3-fold greater rate of re-intervention compared to patients with none or mid disease of other valves (HRcrude 2.3; 95% IC 1.221–4.331, p=0.017). After adjusting for the success of the PMC and for mitral regurgitation after PMC, the observed effect remained significant (HRadjusted = 2.7; 95% CI 1.417–5.233, p=0.003). Conclusion PMC was safe and effective in clinically significant rheumatic MS. Most of the patients were free from adverse events after 10 years and half were alive after 30 years. Still, about 40% required re-intervention, with moderate disease of other valves as its independent predictor. Funding Acknowledgement Type of funding sources: None.
Measurement of radiation absorbed dose in endovascular Ho-166 brachytherapy using a balloon angio-catheter (2000)

The purpose of this study was to estimate the absorbed dose distribution of Ho-166 endovascular beta irradiation using an angio-catheter. The liquid form of Ho-166 was produced at the Korea Atomic Energy Research Institute (KAERI) by an (n,gamma) reaction. Ho-166 has a half-life of 26.8 h and emits a high-energy beta particle with a maximum energy of 1.85 MeV. GafChromic film was used for the estimation of the absorbed dose of beta particles. A Co-60 teletherapy source and a 6 MV photon beam from a linear accelerator were used to generate dose-optical density calibration curves. The exposed films were read using a videodensitometer. With a modified micrometer, the film was positioned accurately on the surface of the balloon in water. The balloon was filled with Ho-166 solution to a pressure of 4 atm. Several film exposures were made with varying irradiation times and activities. The radiation absorbed dose rates were 1.02, 0.51 and 0.35 Gy x min(-1) x GBq(-1) x ml(-1) at the balloon surface, 0.5 and 1 mm from the balloon surface, respectively. The absorbed dose distribution revealed that Ho-166 is a good source for endovascular irradiation as the beta range is very short, avoiding unnecessary irradiation of normal tissue. A clinically applicable irradiation and duration of exposure were achievable utilizing our system.
Bulk processing of HgBaCuO high T/sub c/ superconductors by a two-zone technique (1995)

Hg1201 superconductors have been synthesized from Ba-Cu-O precursors in a two zone assembly. Critical temperatures of 92 K as prepared and 95 K after oxygen annealing resulted. The Hg1201 phase forms at mercury pressures above 6 bar (800/spl deg/C) and at temperatures between 750/spl deg/C and 850/spl deg/C. The effect of dopants on melting and annealing temperatures of the precursor materials has also been studied. After Li doping of up to 20%, melting peaks shift to lower temperatures and broaden significantly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Awake craniotomy for glioblastoma in a 9‐year‐old child (2004)

We report the pre-operative preparation and anaesthetic management for resection of an intracerebral tumour during awake craniotomy in a 9-year-old boy. We believe this is the youngest patient reported to have undergone this procedure. The challenges of sedation and psychological care throughout the procedure are discussed. We conclude that the procedure can be performed safely and that it seems unacceptable to uphold an age restriction. We believe that it is the individual level of development of the child that determines suitability for this type of surgery.
Complexation of Whey Proteins with Carrageenan (2004)

The formation of electrostatic complexes of whey protein (WP) and a nongelling carrageenan (CG) was investigated as a function of pH, ionic strength, temperature, and protein-to-polysaccharide (Pr:Ps) ratio. On lowering the pH, the formation of soluble WP/CG complexes was initiated at pH(c) and insoluble complexes at pH(phi), below which precipitation occurred. The values of the transition pH varied as a function of the ionic strength. It was shown that at [NaCl] = 45 mM, the value of pH(phi) was the highest, showing that the presence of monovalent ions was favorable to the formation of complexes by screening the residual negative charges of the CG. When CaCl(2) was added to the mixtures, complexes of WP/CG were formed up to pH 8 via calcium bridging. The electrostatic nature of the primary interaction was confirmed from the slight effect of temperature on the pH(phi). Increasing the Pr:Ps ratio led to an increase of the pH(phi) until a ratio of 30:1 (w/w), at which saturation of the CG chain seemed to be reached. The behavior of WP/CG complexes was investigated at a low Pr:Ps ratio, when the biopolymers were mixed directly at low pH. It resulted in an increase of the pH of the mixture, as compared to the initial pH of the separate WP and CG solutions. The pH increase was accompanied by a decrease in conductivity. The trapping of protons inside the complex probably resulted from a residual negative charge on the CG. If NaCl was present in the mixture, the complex took up the Na(+) ions instead of the H(+) ions.
An Always-On 3.8 <inline-formula> <tex-math notation="LaTeX">$\mu$ </tex-math> </inline-formula>J/86% CIFAR-10 Mixed-Signal Binary CNN Processor With All Memory on Chip in 28-nm CMOS (2018)

The trend of pushing inference from cloud to edge due to concerns of latency, bandwidth, and privacy has created demand for energy-efficient neural network hardware. This paper presents a mixed-signal binary convolutional neural network (CNN) processor for always-on inference applications that achieves 3.8 μJ/classification at 86% accuracy on the CIFAR-10 image classification data set. The goal of this paper is to establish the minimum-energy point for the representative CIFAR-10 inference task, using the available design tradeoffs. The BinaryNet algorithm for training neural networks with weights and activations constrained to +1 and -1 drastically simplifies multiplications to XNOR and allows integrating all memory on-chip. A weight-stationary, data-parallel architecture with input reuse amortizes memory access across many computations, leaving wide vector summation as the remaining energy bottleneck. This design features an energy-efficient switched-capacitor (SC) neuron that addresses this challenge, employing a 1024-bit thermometer-coded capacitive digital-to-analog converter (CDAC) section for summing pointwise products of CNN filter weights and activations and a 9-bit binary-weighted section for adding the filter bias. The design occupies 6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in 28-nm CMOS, contains 328 kB of on-chip SRAM, operates at 237 frames/s (FPS), and consumes 0.9 mW from 0.6 V/0.8 V supplies. The corresponding energy per classification (3.8 μJ) amounts to a 40× improvement over the previous low-energy benchmark on CIFAR-10, achieved in part by sacrificing some programmability. The SC neuron array is 12.9× more energy efficient than a synthesized digital implementation, which amounts to a 4× advantage in system-level energy per classification.
Modeling for High-Speed Interconnects in Mobile Device Hinge Structures (2006)

Data interconnects have become important functionality determining technology in mobile devices recently. Analysis and modeling of interconnects are integral part of electro-mechanical design of devices that have integrated high pixel count display and mega-pixel camera modules. Several high-speed serial data interfacing solutions have been introduced for data connectivity during last years. Different device form factors create the need for transferring data over hinge using flexible interconnections. The length of the interconnection is highly dependent on the complexity of the hinge structure. The longer interconnect is, the more critical is the electrical performance at high frequencies. Mechanical durability has a major role in the selection of transfer media. Typically flexible printed circuit (FPC) or micro-coaxial (MCX) cables are used. Major design considerations for FPC selection are shielding effectiveness, and selection between different layer structures, from one to three conductor layers. Different shielding materials have been developed to replace the limited bending durability of copper