gebhart/patrepeval huggingface dataset:
Cross-Validation of Machine Learning Models for the Functional Outcome Prediction after Post-Stroke Robot-Assisted Rehabilitation (2022)

The state of the art is still lacking an extensive analysis of which clinical characteristics are leading to better outcomes after robot-assisted rehabilitation on post-stroke patients. Prognostic machine learning-based models could promote the identification of predictive factors and be exploited as Clinical Decision Support Systems (CDSS). For this reason, the aim of this work was to set the first steps toward the development of a CDSS, by the development of machine learning models for the functional outcome prediction of post-stroke patients after upper-limb robotic rehabilitation. Four different regression algorithms were trained and cross-validated using a nested 5×10-fold cross-validation. The performances of each model on the test set were provided through the Median Average Error (MAE) and interquartile range. Additionally, interpretability analyses were performed, to evaluate the contribution of the features to the prediction. The results on the two best performing models showed a MAE of 13.6 [13.4] and 13.3 [14.8] on the Modified Barthel Index score (MBI). The interpretability analyses highlighted the Fugl-Meyer Assessment, MBI, and age as the most relevant features for the prediction of the outcome. This work showed promising results in terms of outcome prognosis after robot-assisted treatment. Further research should be planned for the development, validation and translation into clinical practice of CDSS in rehabilitation. Clinical relevance- This work establishes the premises for the development of data-driven tools able to support the clinical decision for the selection and optimisation of the robotic rehabilitation treatment.
Blocking the Expression of CD33 Enhances Chemotaxis of Activated T Lymphocytes Generated from AML Patients. (2004)

Autologous T lymphocytes can be employed for immune therapy of patients with acute myeloid leukemia (AML). In an earlier study (Biol Blood Marrow Transplant2002; 8:557), we found that AML cells can be used as antigen presenting cells to activate and expand T cells in culture with IL-2 and monoclonal antibody (mAb) to CD3. In this study, we found that a substantial proportion of the expanded T cells expressed CD33 (34 ± 16%; range: 8 – 58%; N=11) and CD13 (26 ± 5%; range: 22 – 33%), but not CD14. It is unlikely that the myeloid markers were absorbed onto the activated T cells, since the same expression pattern was observed in cultures with purified T cells from normal donors. A literature review disclosed two reports that also observed co-expression of CD33 on activated T cells from both AML patients and normal controls (Schmidt-Wolf et al, Br J Haematol.1995; 90:512; Nakamura et al, letter in Blood, 1994; 83:1442). We measured the functional capacity of the activated T cells in a 4-hr Cr-51 release assay. Pre-incubation of the T cells with anti-CD33 mAb and/or anti-CD13 mAb did not change the cytotoxicity against AML cells. Also, killing of AML cells was not affected by the depletion of CD33+ or CD13+ activated T cells using magnetic beads. The activated T cells migrated in a chemotactic response to a peptide analog (CTCE-0214) of Stromal cell derived factor-1 (SDF-1) when measured in a trans-well assay. When activated T cells were pre-incubated with anti-CD33 mAb, enhanced chemotaxis was observed in response to CTCE-0214 (39.9 ± 0.5% vs 26.9 ± 0.3%, p &lt; 0.001). However, incubation with anti-CD13 mAb did not change the proportion of chemotactic cells. The results of this study confirmed that myeloid antigens can be induced on activated T cells from patients with AML and that there are differences in the mobility of CD33+ T cells in the presence of a chemotactic molecule. Further study of the biological significance of CD33 expression on activated T cells in AML and other diseases is warranted.
DFT Study of Anisole Derivatives on Pt(111): Toward lignin decomposition ? (2015)

International audience
Results on visual road recognition for road vehicle guidance (2002)

UBM has developed a vision-based control system which is capable of detecting obstacles, tracking the road, and automatically performing manoeuvres like lane keeping, lane changing, and collision avoidance. This system has been implemented in a van (VaMoRs). Since 1994, the system has been modified to be implemented in a passenger car (VaMP, a Mercedes S class vehicle). Bifocal vision provides a long look-ahead range for normal cruising-speed driving at 130 km/h. The cycle time of 40 ms is short enough for performing real-time reflex-like manoeuvres. For road recognition, the state of the vehicle and the state of the road are recognized by a recursive estimation procedure. Test rides have been performed on freeways, which demonstrated the high robustness of the system. A long distance test ride has been performed from Munich to Odense (Denmark) and back in November 1995, covering more than 1600 km of autonomous ride. Data of the estimation results (curvature on Autobahn and country road, lane width, yaw, angle, and lateral offset) are presented.
Towards achieving robust universal neural vocoding (2018)

This paper explores the potential universality of neural vocoders. We train a WaveRNN-based vocoder on 74 speakers coming from 17 languages. This vocoder is shown to be capable of generating speech of consistently good quality (98% relative mean MUSHRA when compared to natural speech) regardless of whether the input spectrogram comes from a speaker or style seen during training or from an out-of-domain scenario when the recording conditions are studio-quality. When the recordings show significant changes in quality, or when moving towards non-speech vocalizations or singing, the vocoder still significantly outperforms speaker-dependent vocoders, but operates at a lower average relative MUSHRA of 75%. These results are shown to be consistent across languages, regardless of them being seen during training (e.g. English or Japanese) or unseen (e.g. Wolof, Swahili, Ahmaric).
Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma. (1999)

IFN-gamma exerts multiple biological activities in the modulation of immune responses by the induction of transcription factors. One transcriptional factor of the IFN regulatory factor family found to be critical in regulating IL-12-dependent IFN-gamma production in vivo following infectious challenge has been designated IFN consensus sequence-binding protein (ICSBP). In this study, the role of ICSBP in regulating type 1 responses to T cell-specific stimulation in vitro was assessed. Total splenocytes from ICSBP-/- mice stimulated with soluble anti-CD3 were markedly impaired in the production of IFN-gamma compared with similarly stimulated cells from ICSBP+/+ mice. Consistent with the decrease in IFN-gamma production, splenocytes from ICSBP-/- mice stimulated with anti-CD3 in the presence or absence of IFN-gamma or a soluble CD40 ligand agonist failed to produce IL-12 p40 and IL-12 p70 protein; however, the deficient production of IFN-gamma from ICSBP-/- mice could be restored by the addition of anti-CD28 Ab in an IL-12-independent manner. In contrast to the previous data, production of IFN-gamma from naive CD4+/LECAM-1high cells of ICSBP-/- mice that had been primed in vitro with anti-CD3 was similar to or greater than that of ICSBP+/+ controls. In addition, the presence of IFN-gamma in priming cultures enhanced both priming for IFN-gamma and IL-12 responsiveness from ICSBP-/- CD4+ T cells. Overall, these results provide evidence that ICSBP is differentially required for the ability of IFN-gamma to regulate type 1 cytokine responses from APCs and CD4+ T cells.
Relationship between hepatitis B virus DNA in blood and serological markers of hepatitis B infection (1986)

The hepatitis B virus (HBV) DNA dot-hybridization assay has been introduced into clinical practice in Australia and its behaviour compared with that of the classic markers of HBV infection. A good correlation exists between the presence of HBV DNA and that of hepatitis B e antigen but the degree of dissociation between HBV DNA and the e:anti-e system was smaller than earlier studies would suggest. Patients who are seronegative for hepatitis B surface antigen (HBsAg), whether they possess anti-HBs, anti-HBc HBc (antibody to the core antigen), or neither antibody, gave uniformly negative results for the presence of HBV DNA. Theses results are different from those that were obtained from earlier studies of patients with chronic liver disease.
Extracellular Vesicles in Metabolic Syndrome (2017)

Metabolic syndrome defines a cluster of interrelated risk factors for cardiovascular disease and diabetes mellitus. These factors include metabolic abnormalities, such as hyperglycemia, elevated triglyceride levels, low high-density lipoprotein cholesterol levels, high blood pressure, and obesity, mainly central adiposity. In this context, extracellular vesicles (EVs) may represent novel effectors that might help to elucidate disease-specific pathways in metabolic disease. Indeed, EVs (a terminology that encompasses microparticles, exosomes, and apoptotic bodies) are emerging as a novel mean of cell-to-cell communication in physiology and pathology because they represent a new way to convey fundamental information between cells. These microstructures contain proteins, lipids, and genetic information able to modify the phenotype and function of the target cells. EVs carry specific markers of the cell of origin that make possible monitoring their fluctuations in the circulation as potential biomarkers inasmuch their circulating levels are increased in metabolic syndrome patients. Because of the mixed components of EVs, the content or the number of EVs derived from distinct cells of origin, the mode of cell stimulation, and the ensuing mechanisms for their production, it is difficult to attribute specific functions as drivers or biomarkers of diseases. This review reports recent data of EVs from different origins, including endothelial, smooth muscle cells, macrophages, hepatocytes, adipocytes, skeletal muscle, and finally, those from microbiota as bioeffectors of message, leading to metabolic syndrome. Depicting the complexity of the mechanisms involved in their functions reinforce the hypothesis that EVs are valid biomarkers, and they represent targets that can be harnessed for innovative therapeutic approaches.
Intracoronary Low-Dose β-Irradiation Inhibits Neointima Formation After Coronary Artery Balloon Injury in the Swine Restenosis Model (1995)

Administration of endovascular beta-radiation to the site of coronary arterial overstretch balloon injury in pigs with 90Sr/Y is technically feasible and safe. Radiation doses between 7 and 56 Gy showed evidence of inhibition of neointima formation. A dose-response relation was demonstrated, but no further inhibitory effect was seen beyond 28 Gy. These data suggest that intracoronary beta-irradiation is practical and feasible and may aid in preventing clinical restenosis.
A detailed analysis of anatomical plausibility of crossed and uncrossed streamline rendition of the dentato-rubro-thalamic tract (DRT(T)) in a commercial stereotactic planning system (2021)

Since a direct anatomical comparison is difficult in the individual subjects, we chose a comparison with two research tracking environments as the best possible "ground truth." FT2 is useful especially because of its manual editing possibilities of cutting erroneous fibers on the single subject level. An uncertainty of 2 mm as mean displacement of DRTu is expectable and should be respected when using this approach for surgical planning. Tractographic renditions of the DRTx on the single subject level seem to be still illusive.
Simulcast in narrowband PCS (2002)

The uniform distribution of signal energy achieved by simulcast improves wide area reception reliability, but it also introduces additional sources of destructive interference. Our laboratory and field experiments show that simulcast is analogous to multipath with transmitter frequency offsets being equivalent to Doppler shift, and differential propagation delay equal to multipath delay spread. Further, we compare simulcast to cellular architectures. Inherent spectrum inefficiency of the simulcast can be mitigated by reducing the simulcast areas and dynamic boundary variations. For short messages and low user activity, simulcast results in less protocol overhead and a simpler portable device with lower power consumption.
Erythrocytosis associated with a novel missense mutation in the HIF2A gene (2009)

The ERYTHROPOIETIN (EPO) gene is regulated by the transcription factor Hypoxia Inducible Factor-alpha (HIF-alpha). In this pathway, Prolyl Hydroxylase Domain protein 2 (PHD2) hydroxylates two prolyl residues in HIF-alpha, which in turn promotes HIF-alpha degradation by the von Hippel Lindau (VHL) protein. Evidence that HIF-2alpha is the important isoform for EPO regulation in humans comes from the recent observation that mutations in the HIF2A gene are associated with cases of erythrocytosis. We report here a new erythrocytosis-associated mutation, p.Asp539Glu, in the HIF2A gene. Similar to all reported cases, the affected residue is in close vicinity and C-terminal to the primary hydroxylation site in HIF-2alpha, Pro531. This mutation, however, is notable in producing a rather subtle amino acid substitution. Nonetheless, we find that this mutation compromises binding of HIF-2alpha to both PHD2 and VHL, and we propose that this mutation is the cause of erythrocytosis in this individual.
Studies on the Constituents of Vaccinium bracteatum THUNB. II. On the Constituents of the Flowers, particularly on the Structure of Vaccinoside, a New Iridoid Glycoside (1973)

Dried flowers of Vaccinium bracteatum THUNB. were extracted with benzene and methanol. From the benzene extract were isolated hydrocarbons, aldehydes, friedelin, alcohols, ursolic acid (containing a small quantity of oleanolic acid), and maslinic acid (containing a small quantity of 2α-hydroxyursolic acid). From the methanol extract were obtained ursolic acid, p-coumaric acid, β-sitosteryl β-D-glucoside, mixture of fructose and glucose, orientin, isoorientin, shikimic acid, monotropein, and a new iridoid glycoside named vaccinoside (I). The structure of I was elucidated as 10-(p-hydroxy-trans-cinnamoyl)monotropein through the scheme shown in Fig. 1.
Microbial Ecology of the Gut in Laboratory Stocks of the Migratory Grasshopper, Melanoplus sanguinipes (Fab.) (Orthoptera: Acrididae) (1988)

Mean pH values in pooled samples of foregut, midgut, and hindgut from adult Melanoplus sanguinipes, which had been raised in the laboratory on barley shoots and wheat bran, were 5.15, 6.39, and 5.98, respectively. Homogenates of midgut/hindgut sections and frass (feces) yielded colony counts of bacteria by the spread plate method of 5.7 to 5.9 and 5.3 to 5.5 log(10) colonies per mg, respectively; there were no significant differences (P > 0.05) between counts obtained on several media or on media incubated aerobically or anaerobically. There was no evidence of significant populations of protozoa, fungi, or obligately anaerobic bacteria associated with the gut. A total of 168 pure strains of bacteria isolated from the gut sections were characterized and assigned to 11 taxonomic groups, including Enterococcus spp., Serratia liquefaciens, Pseudomonas spp., and Enterobacter spp. Numbers of Enterococcus spp. in the gut were 2 to 3 orders of magnitude higher than those of the other genera. Strains representing only four of the groups were recovered from bran fed to the grasshoppers; the barley shoots, which were raised in sterile soil, appeared virtually sterile. Examination of the gut wall by scanning electron microscopy revealed the presence of epimural bacteria in the foregut and hindgut but not in the midgut. The distribution of epimural cocci and bacilli differed with the gut section examined. Numerous spherical to ovoid structures up to 10 mum in diameter, which were not identified, were associated with the microvillous surface of the midgut epithelium. Acetate was present in gut, hemolymph, and frass, and it was shown that representative isolates of Enterococcus spp. and Enterobacter agglomerans produced acetate when incubated in an aqueous suspension of bran. The egestion time of solid digesta, as measured with methylene blue-stained barley shoots, was 3.0 to 5.7 h. The results show that M. sanguinipes supported extensive indigenous populations of luminal and epimural bacteria in the gut which were composed predominantly of facultatively anaerobic species; the relatively short egestion time, indicating rapid passage of digesta through the gut, was consistent with the microscopic appearance of digesta residues in frass and could account, at least in part, for the absence of a significant population of obligately anaerobic bacteria from the gut.
Low Cycle Fatigue of Thin Metal Films on Vibrating Silicon MEMS Cantilevers: Finite Element Modelling Facilitating Experimental Design (2022)

Within our reliability assessments, we study low cycle fatigue of thin metal films that are essential for the electrical connection in semiconductor devices. The dedicated test vehicle is a silicon-based micro-cantilever with a thin metal meander on top. Using this test vehicle we are able to perform our experiments under isothermal conditions, and, thus, without the interaction of thermal and mechanical influences. The test vehicle was initially designed to induce periodical compressive and tensile strain by resonant shaking of the cantilever beam. Within this paper, we explore the mechanical impact of deflections on the stress state inside the thin Aluminium layers by Finite Element (FE) simulations. This study aids the fundamental understanding of the material behaviour. The results are an important input for the definition of a specification for an upcoming custom-made, low-cost, tabletop test stand. Results indicate that external forces in the mN-range to the cantilever tip result in sufficiently large deflections up to a few mm. We found a linear relation between the maximum cantilever deflection and the maximum meander deflection. The minimum cantilever deflection needed to address low cycle fatigue (plastic deformation) of the 1-µm-thick Aluminium layer lies at 0.6 mm. In this case, part of the Aluminium meander also stays within the elastic region. Deflections greater than 0.6 mm lead to plastic deformation of the full meander length on top of the cantilever. The peak strain is reached shortly after the transition point from body to cantilever and decreases steadily until the end of the metal line.
A Virtualization-Based SaaS Enabling Architecture for Cloud Computing (2010)

With the increasing prevalence of large scale cloud computing environment, researchers has draw more attention about how to provide software as a service through the internet. In this paper, a novel approach named vSaaS is proposed in iVIC platform, which is the virtual computing environment for HaaS and SaaS applications. The aim of this approach is to provide the software as a service from a cloud computing environment over the Internet; users are able to access different software transparently with no limitation on the client operation system or device capability. OS-level virtualization and remote display technologies are employed in the vSaaS system. Benefit from above technologies, massive exist legacy software could be easily adopted without any recompilation and redevelopment work. Software can be dynamic streaming deployed in the back-end resource pool in a dynamic streaming way. Finally, comprehensive experiments are conducted to demonstrate the feasibility and performance of the vSaaS implementation.
SASTRA LISAN MANTRA PENGOBATAN DI KENAGARIAN TALU KECAMATAN TALAMAU KABUPATEN PASAMAN BARAT (2013)

This research aims to describe the (1) the structure of the text spells treatment, (2) supporting aspects spells reading of treatment, (3) the treatment of inheritance spells. This research uses a qualitative approach with descriptive methods. Data were collected through observation, interviews, and recording. The results showed that the structure of the text spells treatment consists of: the opening section, part of the contents, and the end. Supporting aspects spells reading of treatment in Kenagarian Talu found: (1) time: free, wherever, (2) actors: shaman himself, (3) events: be seated, standing and kneeling, (4) where: in shaman home and patient home, (5) clothing: white clothes and free, (6) fixtures: medicine fit the type of illness, medicine is attached and drunk, (7) how to bring spell: slowly, cautiously, and whispered. Inheritance process of treatment spell is divided into two, (1) spells obtained from the parents, but some are obtained from family members, such as brothers, and (2) generally passed on to children.
In‐building power lines as high‐speed communication channels: channel characterization and a test channel ensemble (2003)

Abstract In‐building power lines have often been considered as attractive media for high‐speed data transmission, particularly for applications like home networking. In this paper, we develop models for power line channels based both on theoretical considerations and practical measurements. We consider power line channel frequency response and noise models in the 1–30 MHz band and propose a number of power line test channels in which to measure the performance of power line modems. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Unexpected second-order nonlinear optical effects in conjugated polymers (2011)

Conjugated polymers do not only attract great attention due to their suitability in organic transistors, light emitting diodes and solar cells, moreover, they posses unexpected record-high second-order nonlinear optical responses. Nonlinear optical polymers have been reported as attractive materials for space applications such as electro-optic modulation and optical power limiting. In this work, we report on a new approach for increased second-order nonlinear properties demonstrated in a series of poly(thiophene) derivatives and poly(phenanthrene)s.
Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA (2010)

Two independent cervimycin C (CmC)-resistant clones of Bacillus subtilis were identified, each carrying two mutations in the intergenic region preceding the ABC transporter gene bmrA. In the double mutant, real-time PCR revealed an increased amount of bmrA mRNA with increased stability. Accordingly, isolation of membrane proteins yielded a strong band at 64 kDa corresponding to BmrA. Analyses showed that one mutation optimized the -35 box sequence conferring resistance to 3 μM CmC, while the +6 mutation alone had no effect, but increased the potential of the strain harboring the -35 mutation to grow at 5 μM CmC. Transcriptional fusions revealed an elevated bmrA promoter activity for the double mutant. Electrophoretic mobility shift assays (EMSAs) confirmed a 30-fold higher binding affinity of RNA polymerase for this mutant compared with the wild type, and the effect was due to the -35 box alteration of the bmrA promoter. In vitro transcription experiments substantiated the results of the EMSA. EMSAs in the presence of heparin indicated that the mutations did not influence the formation and/or the stability of open complexes. Half-life measurements demonstrated that the +6 mutation stabilized bmrA mRNA ≈ 2-fold. Overall, we found that an ABC transporter confers antibiotic resistance by the cumulative effects of two mutations in the promoter region.