gebhart/patrepeval huggingface dataset:
LOS ACEITES ESENCIALES PODRÍAN REDUCIR EL RIESGO DE CETOSIS EN CABRAS LECHERAS CON GESTACIÓN MÚLTIPLE (2009)

Dairy goats are highly susceptible to gestational ketosis. Ketosis is the result of an unbalance between energy supply and requirements. The hypothesis was that by increasing intake and glucose precursors (propionate), the indicators of ketosis will be reduced. Twenty four pregnant Murciano-Granadina goats carrying twins were used to study the effects of feeding a mixture of capsicum (that has been shown to stimulate intake) and eugenol plus cinnemaldehyde (that have been shown to promote propionate production in the rumen) on DM intake, milk production and composition, and blood profile. Goats were controlled from 2 weeks prior to 6 weeks after kidding. During the experiment, goats received a TMR diet (DM of a 60:40 forage: concentrate). Treatments were a control (CTR; no additive) and a mixture of capsicum eugenol and cinnamaldehyde (CEC, Pancosma, Switzerland). Intake and milk production were recorded daily, milk composition determined weekly, and blood samples taken days -10, -7, -3, -2, -1, 0, 1, 2, 3, 5, 7 and 15 around kidding to measure insulin, glucose, non-esterified fatty acids (NEFA), triglycerides and betahydroxy-butyrate (BOHB). Results were analyzed using the PROC MIXED procedure of SAS, differences declared at P < 0.05, and tendencies discussed at P < 0.10. No effects were found on feed intake or milk production, However, milk fat (6.48 vs. 5.84 g/Kg) and milk protein (3.86 vs. 3.69 g/kg) were higher in CEC compared with CTR. Plasma insulin concentration tended (P = 0.05) to be higher (0.49 vs. 0.40 μg/l), AGNE tended (P = 0.09) to be lower (0.52 vs. 0.62 mmol/l) and BOHB was lower (0.44 vs. 0.53 mmol/l) in the CEC treatment compared with CTR, respectively. Results suggest that the effects of the combination of cinnamaldehyde, eugenol and capsicum on ruminal fermentation increased the supply of glucose and reduced body fat mobilization, reducing the risk of ketosis during the periparturient period.
Abbildungen (2023)

No AccessIngenieurmathematikMar 2023AbbildungenPaul Wolf, Sophie Kersting, Stefan Friedenberg, Fíona MahlbergPaul Wolf, Sophie Kersting, Stefan Friedenberg, Fíona Mahlberghttps://doi.org/10.3139/9783446477261.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2023Pages: 159-211Print ISBN: 978-3-446-47616-5eISBN: 978-3-446-47726-1 Copyright & Permissions© 2023 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Improved conversion efficiency of p-type BaSi2/n-type crystalline Si heterojunction solar cells by a low growth rate deposition of BaSi2 (2022)

The effect of low growth rate deposition (LGD) of BaSi2 on the film quality and performance of silicon heterojunction solar cells was investigated. The total thickness of the BaSi2 layer decreased with increasing LGD duration (tLGD). Analysis using Raman spectroscopy indicated that an amorphous Si (a-Si) phase existed on the surface of the BaSi2 layer. The a-Si on the surface was converted into BaSi2 by post-annealing owing to the diffusion of Ba and Si atoms. X-ray diffraction analysis revealed that LGD improved the rate of a-axis orientation and crystallinity. Post-annealing was also observed to have significantly improved these structural properties. Furthermore, the solar cell performance was observed to be strongly dependent on tLGD, and the highest conversion efficiency of 10.62% was achieved by the p-BaSi2/n-c-Si heterojunction solar cells at a tLGD of 6 min. The improved structure and solar cell properties are attributed to improved atom rearrangement during LGD.
Systems and methods for distributing power using photovoltaic resources and a shifting battery system (2023)

The present invention is an apparatus and method for delivering energy using a renewable resource. The method includes providing a photovoltaic energy source and applying energy storage to the photovoltaic energy source via a battery storage unit. The energy output from the photovoltaic energy source and the battery system is controlled using a battery control system. The battery control system predicts peak load, develops a schedule that includes when to begin discharging power and when to stop discharging power, shifts power to the battery storage unit when excess power is available, and prioritizes the functionality of the battery storage unit and the photovoltaic energy source.
Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH2-Terminal Kinase-Specific Kinase (1997)

At least three mitogen-activated protein kinase (MAPK) cascades were identified in mammals, each consisting of a well-defined three-kinase module composed of a MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). These cascades play key roles in relaying various physiological, environmental, or pathological signals from the environment to the transcriptional machinery in the nucleus. One of these MAPKs, c-Jun N-terminal kinase (JNK), stimulates the transcriptional activity of c-Jun in response to growth factors, proinflammatory cytokines, and certain environmental stresses, such as short wavelength UV light or osmotic shock. The JNKs are directly activated by the MAPKK JNKK1/SEK1/MKK4. However, inactivation of the gene encoding this MAPKK by homologous recombination suggested the existence of at least one more JNK-activating kinase. Recently, the JNK cascade was found to be structurally and functionally conserved in Drosophila, where DJNK is activated by the MAPKK DJNKK (hep). By a database search, we identified an expressed sequence tag (EST) encoding a portion of human MAPKK that is highly related to DJNKK (hep). We used this EST to isolate a full-length cDNA clone encoding a human JNKK2. We show that JNKK2 is a highly specific JNK kinase. Unlike JNKK1, it does not activate the related MAPK, p38. Although the regulation of JNKK1 activities and that of JNKK2 activities could be very similar, the two kinases may play somewhat different regulatory roles in a cell-type-dependent manner.
Zhibitai and low-dose atorvastatin reduce blood lipids and inflammation in patients with coronary artery disease (2017)

ZA10 significantly reduced triglycerides, TC, LDL-C, ApoB, CT-1, and hs-CRP levels in patients with CHD, similar to the effects of A40 and A20, but ZA10 lead to fewer adverse events.
Soul of the City: Public Space and Urban Planning in Hong Kong (2021)

This chapter posits that public space is the soul of a city, and it defines the essence of urbanity. Public space reflects the quality of life and the characteristics of its city and the people. It also provides the lens for analyzing the political economy of a high-density city like Hong Kong. This chapter illustrates how the planning, design and provision of urban open space are subject not only to the influences of changing political, social and economic forces but also to the development trajectory of the city that progresses from industrial capitalism to global capitalism. It will explore the emerging trends of public space provision and management in this city and will advocate the importance of urban planning in mitigating some undesirable consequences.
Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050 (2015)

New strategies targeting Plasmodium falciparum gametocytes, the sexual-stage parasites that are responsible for malaria transmission, are needed to eradicate this disease. Most commonly used antimalarials are ineffective against P. falciparum gametocytes, allowing patients to continue to be infectious for over a week after asexual parasite clearance. A recent screen for gametocytocidal compounds demonstrated that the carboxylic polyether ionophore maduramicin is active at low nanomolar concentrations against P. falciparum sexual stages. In this study, we showed that maduramicin has an EC50 (effective concentration that inhibits the signal by 50%) of 14.8 nM against late-stage gametocytes and significantly blocks in vivo transmission in a mouse model of malaria transmission. In contrast to other reported gametocytocidal agents, maduramicin acts rapidly in vitro, eliminating gametocytes and asexual schizonts in less than 12 h without affecting uninfected red blood cells (RBCs). Ring stage parasites are cleared by 24 h. Within an hour of drug treatment, 40% of the normally crescent-shaped gametocytes round up and become spherical. The number of round gametocytes increases to >60% by 2 h, even before a change in membrane potential as monitored by MitoProbe DiIC1 (5) is detectable. Maduramicin is not preferentially taken up by gametocyte-infected RBCs compared to uninfected RBCs, suggesting that gametocytes are more sensitive to alterations in cation concentration than RBCs. Moreover, the addition of 15.6 nM maduramicin enhanced the gametocytocidal activity of the pyrazoleamide PA21A050, which is a promising new antimalarial candidate associated with an increase in intracellular Na(+) concentration that is proposed to be due to inhibition of PfATP4, a putative Na(+) pump. These results underscore the importance of cation homeostasis in sexual as well as asexual intraerythrocytic-stage P. falciparum parasites and the potential of targeting this pathway for drug development.
Synthesis and Evaluation of PEG Derivatives for Crosslinking Cells (2007)

Abstract The objective of this study is synthesis, characterization, and evaluation of a novel crosslinker to form spheroids. Our approach was based on the crosslinking of cell membrane using a polymeric crosslinker via hydrophobic interaction. A crosslinker poly(ethylene glycol) derivative with oleyl groups as hydrophobic group at both ends was synthesized, and then characterized with gel permeation chromatography and Fourier‐transform infrared spectroscopy. Furthermore, cell culture experiments were performed to confirm spheroid formation. Spheroids were successfully obtained when the crosslinker was added to cell suspension. This polymeric crosslinker was useful in the formation of cell spheroid.
Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol‐dependent cytolysins (2021)

Certain species of pathogenic bacteria damage tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes of animal cells. However, reducing cholesterol protects cells against these cytolysins. As the first committed step of cholesterol biosynthesis is catalyzed by squalene synthase, we explored whether inhibiting this enzyme protected cells against cholesterol-dependent cytolysins. We first synthesized 22 different nitrogen-containing bisphosphonate molecules that were designed to inhibit squalene synthase. Squalene synthase inhibition was quantified using a cell-free enzyme assay, and validated by computer modeling of bisphosphonate molecules binding to squalene synthase. The bisphosphonates were then screened for their ability to protect HeLa cells against the damage caused by the cholesterol-dependent cytolysin, pyolysin. The most effective bisphosphonate reduced pyolysin-induced leakage of lactate dehydrogenase into cell supernatants by >80%, and reduced pyolysin-induced cytolysis from >75% to <25%. In addition, this bisphosphonate reduced pyolysin-induced leakage of potassium from cells, limited changes in the cytoskeleton, prevented mitogen-activated protein kinases cell stress responses, and reduced cellular cholesterol. The bisphosphonate also protected cells against another cholesterol-dependent cytolysin, streptolysin O, and protected lung epithelial cells and primary dermal fibroblasts against cytolysis. Our findings imply that treatment with bisphosphonates that inhibit squalene synthase might help protect tissues against pathogenic bacteria that secrete cholesterol-dependent cytolysins.
Rho GTPases and leucocyte-induced endothelial remodelling (2005)

Leucocytes in the bloodstream respond rapidly to inflammatory signals by crossing the blood vessel wall and entering the tissues. This process involves adhesion to, and subsequent transmigration across, the endothelium, mediated by a cascade of interactions between adhesion molecules and stimulation of intracellular signalling pathways in both leucocytes and endothelial cells. This leads to changes in endothelial cell morphology that assist leucocyte extravasation, including endothelial cell contraction, intercellular junction disruption, increased permeability, remodelling of the endothelial apical surface and alterations in vesicle trafficking. Rho GTPases play a central role in many of the endothelial responses to leucocyte interaction. In this review, we discuss recent findings on leucocyte-induced alterations to endothelial cells, and the roles of Rho GTPases in these responses.
The Role of “Eye Platelet Rich Plasma” (E-Prp) for Wound Healing in Ophthalmology (2012)

Blood derived products have demonstrated their capacity to enhance healing and stimulate the regeneration of different tissues and this enhancing effect is attributed to the growth factors and bioactive proteins that are synthesized and present in blood. Eye platelet rich plasma (E-PRP) provides higher concentration of essential growth factors and cell adhesion molecules by concentrating platelets in a small volume of plasma as compared with autologous serum, the latter being used widely in ophthalmology for epithelial wound healing of the cornea for the last two decades. These growth factors and cell adhesion molecules have a major role in wound healing and enhance the physiological process at the site of the injury/surgery via eye drops or clot. E-PRP has been used more recently, and has achieved successful outcomes in peer-review articles in the treatment of dormant ulcers (epithelial defects of the cornea that fail to heal), moderate to severe dry eye syndrome, ocular surface syndrome post Laser In Situ Keratomileusis (LASIK), and for surface reconstruction after corneal perforation associated with amniotic membrane transplantation. Preparation of E-PRP in the two available formulations, eyedrops and clot, is inexpensive and easy although it requires following strict sterility conditions using sterile and disposable materials and operating inside a laminar flow hood. No serious adverse effects have been described with the use of these products, and it is generally well tolerated. In summary, Platelet enriched plasma in the form obtained in ophthalmology, E-PRP, is a reliable and effective therapeutic tool to enhance epithelial wound healing in ocular surface disease.
The concept of the digital twin of the production system in the process of digital transformation of the production process model in power engineering (2021)

Based on the concept of system engineering (ISO-15288), an approach to formalization and integration of existing poorly structured models of planning and production, management is proposed. The necessary methodological and informational requirements are defined to ensure the definability, traceability and manageability of production processes of enterprises for decision-making during planning and management.
A robust clustering algorithm based on competitive agglomeration and soft rejection of outliers (1996)

We present a new clustering algorithm that addresses two major issues associated with conventional partitional clustering: the difficulty in determining the number of clusters, and the sensitivity to noise and outliers. The proposed algorithm determines the number of clusters by a process of competitive agglomeration. Noise immunity is achieved by integrating concepts from robust statistics into the algorithm. The proposed approach can incorporate different distance measures in the objective function to find an unknown number of clusters of various types including lines, planes and surfaces.
Efficacy of endoscopic diagnosis and treatment for postoperative biliary leak. (1998)

The patients with postoperative biliary leaks can be successfully diagnosed by ERCP and treated by temporary endoscopic methods. Among various endoscopic treatments, NBD alone appears to be preferable in treating patients with small bile leaks. However, cases with a concomitant bile duct stricture were intractable and required longer period of stenting.
Study of SAW properties of temperature-compensated orientations in berlinite (1982)

A study of the surface acoustic wave (SAW) properties in three singly and two doubly rotated temperature-compensated berlinite cuts has been performed. The measured SAW properties were the velocity, the electromagnetic to acoustic coupling (Δv/v) and the frequency/temperature characteristics (Δf/f). Comparisons are made between theory and experiment.
The Current Status of Devices for the Treatment of Resistant Hypertension (2019)

Arterial hypertension is associated with increased cardiovascular morbidity and mortality. Although blood pressure-lowering therapies significantly reduce the risk of major cardiovascular events, blood pressure control remains unsatisfactorily low. Several device-based antihypertensive therapies have been investigated in patients with treatment-resistant hypertension and in patients unable or unwilling to adhere to antihypertensive medication. As the field of device-based therapies is subject to constant change, this review aims at providing an up-to-date overview of different device-based approaches for the treatment of hypertension. These approaches target the sympathetic nervous system (renal denervation, baroreflex amplification therapy, baroreflex activation therapy, and carotid body ablation) or alter mechanical arterial properties by creating an iliac arteriovenous fistula. Notably, the use of all of these treatment options is not recommended for the routine treatment of hypertension by current guidelines but should be investigated in the context of controlled clinical studies.
Decreased Expression of the Chromatin Remodeler ATRX Associates with Melanoma Progression (2014)

spili. HRAS mutations have recently been demonstrated in a number of hamartomatous cutaneous neoplasms including epidermal nevi and nevus sebaceous (Groesser et al., 2012; Hafner et al., 2012; Levinsohn et al., 2012; Sun et al., 2013). When these alterations occur early in development or affect multiple cell lineages, they can result in developmental syndromes called ‘RASopathies,’ such as Schimmelpenning, epidermal nevus syndrome, and phacomatosis pigmentokeratotica (Hafner and Groesser, 2013). The HRAS point mutation (c.37G-4C, p.Gly13Arg), in particular, appears to be overrepresented among HRAS mutations in these cutaneous congenital conditions. This mutation allows constitutive activation of RAS pathway likely facilitating the development of secondary neoplasms through accrual of additional genetic alterations. Our finding adds sporadic nevus spilus to the spectrum of congenital cutaneous lesions that harbor activating mutations in HRAS. In nevus spilus, we speculate that the melanocytic neoplasms that arise from these tan patches likely acquire additional genetic alterations that enable progression. Indeed, we have recently demonstrated such a secondary change through amplification of HRAS in Spitz nevi arising out of a nevus spilus (Sarin et al., 2013). However, the secondary mutations that give rise to the diverse spectrum of melanocytic neoplasms have not yet been identified. The knowledge of the genetic basis of nevus spilus represents a further step towards understanding the genetic etiology underlying melanocytic neoplasms. In addition, these lesions represent a unique opportunity to study the genetic alterations that allow progression from a nevus spilus to a nevus or melanoma in the setting of constitutive RAS/MAPK activation.
Treatment of Varicose and Telangiectatic Leg Veins with Hypertonic Saline: A Comparative Study of Heparin and Saline (1990)

The clinical results of treating 800 patients with starburst varicosities using hypertonic saline with and without heparin are described. The extent and type of complications seen in this series of patients are indicated.
Characterization of mm-Wave Conformal Antenna Arrays for a $3\times 8$ MIMO Radar (2019)

In a number of applications millimeter-wave multiple-input multiple-output (MIMO) radars are widely employed. The use of conformal antenna arrays has been recently proposed to improve the radar sensor performance. This paper presents an optimization algorithm for finding the antenna placement in a non-planar arrangement. The experimental characterization of two prototypes based on radar measurements with an experimental 3×8 MIMO radar sensor confirms the results predicted by the numerical simulations. The direction of arrival estimation has been performed successfully, and the measured beampatterns are in very good agreement with the simulated ones.
Conservative Restoration of a Sensitive Cervical Root Lesion (1989)

Certain glass ionomer materials are now available for conservative esthetic restoration of cervical root lesions. Using a premeasured encapsulated glass ionomer system greatly improves and simplifies the restorative procedure. With no mechanical tooth preparation, exposed sensitive root structure can be reliably restored with a remarkably easy technique. A detailed method is described and representative glass ionomer cervical root restorations are shown.
Effect of Hydrocortisone on Acidotic Failure of the Isolated Heart (1957)

Acute myocardial failure observed when the denervated heart-lung preparation is rendered acidotic is mitigated if 5 to 10 mg. of hydrocortisone are administered to the preparation 12 to 15 min. before the onset of ventilation with high CO 2 .
Multi-Task Language Modeling for Improving Speech Recognition of Rare Words (2021)

End-to-end automatic speech recognition (ASR) systems are increasingly popular due to their relative architectural simplicity and competitive performance. However, even though the average accuracy of these systems may be high, the performance on rare content words often lags behind hybrid ASR systems. To address this problem, second-pass rescoring is often applied leveraging upon language modeling (LM). In this paper, we propose a second-pass system with multi-task learning, utilizing semantic targets (such as intent and slot prediction) to improve speech recognition performance. We show that our rescoring model trained with these additional tasks outperforms the baseline rescoring model, trained with only the LM task, by 1.4% on a general test and by 2.6% on a rare word test set in terms of word-error-rate relative (WERR). Our best ASR system with multi-task LM shows 4.6% WERR deduction compared with RNN Transducer only ASR baseline for rare words recognition.
Machine-learning-based patient specific prompt-gamma dose monitoring in protontherapy (2013)

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