gebhart/patrepeval huggingface dataset:
Synthetic Tumor-Associated Glycopeptide Antigens (1990)

Glycopeptides with TN antigen (GalNAc)Ser/Thr and T-antigen structures (beta Gall-3GalNAc)Ser/Thr, described as tumor-associated antigens, were synthesized and coupled to bovine serum albumin. Alternatively, synthetic methods for the construction of beta-anomeric analogues of the TN and T-antigen glycopeptides were developed, aiming at antigenic structures having a varied stereochemistry of the linkage between the carbohydrate and the peptide moiety. As a further type of potential tumor-associated antigen, fucosyl-chitobiose asparagine glycopeptides were synthesized, deprotected, and coupled to bovine serum albumin. The chemical methods developed now make the complex sensitive glycoprotein partial structures accessible in analytically pure form and in preparative amounts.
Genome sequences of two Phytophthora species responsible for Sudden Oak Death and Soybean Root Rot provide novel insights into their evolutionary origins and mechanisms of pathogenesis (2005)

The approximately 60 species of Phytophthora are all destructive pathogens, causing rots of roots, stems, leaves and fruits of a wide range of agriculturally and ornamentally important plants (1). Some species, such as P. cinnamomi, P. parasitica and P. cactorum, each attack hundreds of different plant host species, whereas others are more restricted. Some of the crops where Phytophthora infections cause the greatest financial losses include potato, soybean, tomato, alfalfa, tobacco, peppers, cucurbits, pineapple, strawberry, raspberry and a wide range of perennial tree crops, especially citrus, avocado, almonds, walnuts, apples and cocoa, and they also heavily affect the ornamental, nursery and forestry industries. The economic damage overall to crops in the United States by Phytophthora species is estimated in the tens of billions of dollars, including the costs of control measures, and worldwide it is many times this amount (1). In the northern midwest of the U.S., P. sojae causes $200 million in annual losses to soybean alone, and worldwide causes around $1-2 billion in losses per year. P. infestans infections resulted in the Irish potato famine last century and continues to be a difficult and worsening problem for potato and tomato growers worldwide, with worldwide costs estimated at $5 billion per year.
Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases (2018)

Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized to membranes with a restricted pattern of expression in adult tissues. However, its expression is common in destabilized cells, as it is overexpressed both in inflammatory diseases and in cancer. MAP17 is overexpressed in most, if not all, carcinomas and in many tumors of mesenchymal origin, and correlates with higher grade and poorly differentiated tumors. This overexpression drives deep changes in cell homeostasis including increased oxidative stress, deregulation of signaling pathways and increased growth rates. Importantly, MAP17 is associated in tumors with inflammatory cells infiltration, not only in cancer but in various inflammatory diseases such as Barret’s esophagus, lupus, Crohn’s, psoriasis and COPD. Furthermore, MAP17 also modifies the expression of genes connected to inflammation, showing a clear induction of the inflammatory profile. Since MAP17 appears highly correlated with the infiltration of inflammatory cells in cancer, is MAP17 overexpression an important cellular event connecting tumorigenesis and inflammation?
Bragg–Fresnel multilayer gratings: electromagnetic theory (1994)

We develop an electromagnetic analysis and its numerical implementation for gratings of arbitrary shape etched into a plane multilayer. The multilayer consists of a stack of identical bilayers, each bilayer including two materials (dielectrics and/or metals) with different thicknesses. The analysis is based on the differential theory of gratings, which is generalized to the case of many superimposed gratings by computation of the T matrix of each elementary grating linking the field above the modulated region to the field below it. The product of all the T matrices gives the T matrix of the stack, from which the outgoing wave condition permits derivation of the grating efficiencies. The method, developed for TE polarization, can be used throughout the entire spectrum, but it is particularly useful in the soft-x-ray region. Examples of performances of multilayer gratings in this spectral domain are computed.
Investigation of Torque–Speed Characteristics and Cogging Torque of Fractional-Slot IPM Brushless AC Machines Having Alternate Slot Openings (2012)

This paper presents a comparative study of torque-speed characteristics and cogging torque of the fractional-slot interior permanent magnet brushless ac machines having different slot openings, viz. open slot, closed slot, and hybrid slot (sandwiched open and closed slots), and unskewed and step skewed rotors. The influence of such alternate slot openings on the magnetic cross-coupling and cogging torque is particularly emphasized. Furthermore, the repercussion of the manufacturing limitations and tolerances on the cogging torque of machines having these alternate slot openings is also investigated. The magnetic cross-coupling level and the sensitivity of cogging torque to manufacturing limitations and tolerances strongly depend on the slot opening materials. The finite-element analyses are experimentally validated.
Biofilms in the Food and Beverage Industries (2009)

Part 1 Biofilms in the food and beverage industries: Biofilms in the food and beverage industries: an introduction Molecular mechanisms involved in biofilm formation by food-associated bacteria Methods for imaging and quantifying the structure of biofilms in food processing and other environments Monitoring of biofilms in the food and beverage industries A centralized database for use in studying bacterial biofilms and quorum sensing in food processing and other environments: MicroBQs. Part 2 Microorganisms and their metabolites in biofilms: Biofilm formation by food spoilage microorganisms in food processing environments Biofilm formation by Listeria monocytogenes and transfer to foods Biofilm formation by Salmonella in food processing environments Biofilm formation by Gram-positive bacteria including Staphylococcus aureus, Mycobacterium avium and Enterococcus spp in food processing environments Biofilm formation by spore-forming bacteria in food processing environments. Part 3 Biofilm prevention, inactivation and removal and beneficial biofilms: Food contact surfaces, surface soiling and biofilm formation Cleaning and sanitation in food processing environments for the prevention of biofilm formation and biofilm removal Novel methods for biofilm control and removal from food processing equipment. Part 4 Biofilms in particular food industry sectors: Biofilms in red meat processing Biofilms in dairy processing Biofilms and brewing Biofilms in poultry processing Beneficial biofilms: wastewater and other industrial applications Biofilms in fish processing Biofilms in fresh fruit and vegetables. Part 5 Appendix: Sampling and quantification of biofilms in food processing and other environments.
Group key management for wireless networks (2008)

With the advancement of wireless networks in recent years, group communication via wireless networks is becoming an increasingly popular research area due to the growth of group oriented applications such as video conferencing, pay-per-view media distribution, real-time information services and collaborative work in wireless networks. Besides civilian applications mentioned above, group-oriented applications and protocols are also used widely in military operations. However, group communication via wireless networks takes place over radio waves, the common mode of communication in wireless networks, causes major security concern as radio transmission can be easily eavesdropped. Solutions such as IPSec that provides end-to-end secure communications between two communicating parties and user nodes would require many different secret keys to communicate with every other node in the network. A better solution is to use a shared secret group key for secure group communications in a wireless network. To achieve this, the nodes in the wireless network will first run a group key management (GKM) protocol to establish a common group key. This key will then be used as a secret key for symmetric-key cryptography to encrypt messages that they wish to broadcast to the wireless network. In this way, entities outside the wireless network will not be able to decode these messages.
Critical experiments, measurements and analyses to establish a crack arrest methodology for nuclear pressure vessel steels. Fourth quarterly progress report, Task 62 (1975)

A series of calculations are reported which explore the significance of a K/sub D/ that decreases with increasing crack velocity. The effect on K/sub a/, the crack propagation behavior, and the model instabilities which develop are described in detail. A series of experiments on contoured specimens are described and compared with MRL data. Several difficulties were encountered in these tests, among them being relatively short crack extensions to the first halt coupled with difficulties in making accurate crack velocity measurements near the onset of propagation. It is also found that the machine interaction may cause additional propagation. The model accurately describes the initial portion of the event but repropagations which occur due to energy input from the test machine are difficult to characterize. Additional K/sub D/ data for A533B have been collected and the complete set of data available to date is reported. At low temperature (NDT-66C) K/sub D/ is relatively independent of crack velocity with a possible increase starting at about 900 ms/sup -1/. At NDT K/sub D/ decreases modestly with increasing crack velocity. At a slightly higher temperature (NDT + 36C) K/sub D/ again appears to decrease with velocity. The relevance of K/sub D/ to K/sub d/, themore » dynamically-loaded, crack-initiation toughness, is discussed.« less
Transient impact response of plates containing flaws (1987)

The finite element method was used to study the transient response to point impact of thick circular plates containing disk-shaped flaws. The response was studied in both the time and the frequency domains, and compared to the response obtained from a solid plate. The effects on the response caused by changing the diameter and depth of a flaw, the duration of the impact, and the position where the response is calculated were determined. From the results of these parameter studies, conclusions were drawn which can be used in planning and interpreting impact-echo laboratory and field test results.
Nonlinear vibration energy harvesting device integrating mechanical stoppers used as synchronous mechanical switches (2014)

Nonlinear energy extraction techniques for piezoelectric vibration energy harvesting usually require synchronized electronic switches in their electronic interface circuits. But the difficulty to self-power their complex switching control strategies limits their performances, especially in the presence of wideband ambient excitations. This technical note presents a nonlinear energy extraction interface achieved by synchronous mechanical switches. The complex switching control strategy is dodged by taking advantage of mechanical stoppers and the moving part of the piezoelectric oscillator, which is driven by the vibration itself. As a result, the added mechanical stoppers and the self-synchronized nonlinear energy extraction circuit also make the energy harvesting device system be particularly suited to wideband ambient vibrations.
Principal Component Analysis in Multiple Description Coding of Spectral Images (2008)

Communications in general require protection due to error-prone channels. In geoscience and remote sensing, especially coded or compressed data, and results from classifications are vulnerable to transmissions errors. Multiple descriptions of data are one way for protection of communications over unreliable channels. This study concentrates on multiple description of spectral images as a way for providing scalable coding. The principal component analysis outputs the common content, the redundant part, for the two descriptions and then the integer wavelet transform selects different contents for those descriptions. In the experiments, the goal was to find good parameterization in the transmitter for generating the two descriptions which will allow perfect reconstruction if both of them are available at the receiver. The reconstruction quality for various number of principal components is demonstrated. Integer wavelet filter 5/3 showed the best performance among the implemented filters.
Magnetic Resonance Imaging in Patients with Recently Implanted Pacemakers (2013)

With a strong clinical indication and with careful monitoring, MRI imaging is feasible in patients with recently implanted pacemakers, although experience is limited.
FORMULATION, OPTIMIZATION AND EVALUATION OF STOMACH SPECIFIC IN-SITU GEL OF HYDROCHLOROTHIAZIDE (2013)

The objectives of this research work were preparation, optimization and evaluation of in situ gelling system of Hydrochlorothiazide based on pectin that retains in the stomach by adherence to gastric wall providing an increased gastric residence time resulting in prolonged drug delivery in gastrointestinal tract. Pectin was used as a polymer and CaCO3 as a cross-linking agent. The in situ formulation exhibited the expectations, viscosity, drug content and sustained drug release. This study reports that oral administration of aqueous solutions containing pectin results in formation of in situ gel and such formulations are homogenous liquids when administered orally and become gel at the contact site. The results of a 3 2 full factorial design revealed that the concentrations of pectin and CaCO3 significantly affected the dependent variables of viscosity, drug content (%) and Q18. These in situ gels are, thus, suitable for oral sustained release of Hydrochlorothiazide.
Accelerating Development of EV Batteries Through Computer-Aided Engineering (2012)

The Department of Energy's Vehicle Technology Program has launched the Computer-Aided Engineering for Automotive Batteries (CAEBAT) project to work with national labs, industry and software venders to develop sophisticated software. As coordinator, NREL has teamed with a number of companies to help improve and accelerate battery design and production. This presentation provides an overview of CAEBAT, including its predictive computer simulation of Li-ion batteries known as the Multi-Scale Multi-Dimensional (MSMD) model framework. MSMD's modular, flexible architecture connects the physics of battery charge/discharge processes, thermal control, safety and reliability in a computationally efficient manner. This allows independent development of submodels at the cell and pack levels.
A new electrochemical platform based on P450 2C8 for drug discovery (2010)

Cytochrome P450 2C8 is responsible for 10% of drug metabolism in human liver.Among its substrates are the anticancer drug paclitaxel and the antimalarial amodiaquine.In order to meet the need of a reliable and fast drug screening assay for P450, this project aims at the construction of a P450 2C8 electrode.
ChemInform Abstract: Dimetalated Tertiary Succinamides. Alkylation and Annelation Reactions. Dimetalated Tertiary Succinamides. Synthesis of Several Classes of Lignans Including the Mammalian Urinary Lignans Enterolactone and Enterodiol. (1983)

Abstract Die dimetallierten tertiären Succinamide (II) werden stufenweise mit verschiedenen oder auch gleichen elektrophilen Reagenzien zu den disubstituierten 2,3‐Addukten (III) umgesetzt.
Antinociceptive Constituents of Auricularia polytricha (2002)

As part of our project aimed to determine naturally occurring substances with antinociceptive properties, we have previously demonstrated that some triterpenoids present in Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ganodermataceae), such as ganoderic acids A, B, G, and H, and compound C6 are the main active principles of this mushroom [1]. In this study, we have investigated the antinociceptive activity of the fruiting body of Auricularia polytricha (Mont.) Sacc. (Auriculariaceae).
Functional assessment and phenotypic heterogeneity ofSFTPA1andSFTPA2mutations in interstitial lung diseases and lung cancer (2020)

This study, which expands the molecular and clinical spectrum of SP-A disorders, shows that pathogenic <i>SFTPA1</i> or <i>SFTPA2</i> mutations share similar consequences for SP-A secretion in cell models and in lung tissue immunostaining, whereas they are associated with a highly variable phenotypic expression of disease, ranging from severe forms requiring lung transplantation to incomplete penetrance.
Pore size analysis of >250 000 hypothetical zeolites (2011)

Computational methods have been used in the past to generate large libraries of hypothetical zeolite structures, but to date analysis of these structures has typically been limited to relatively simple physical properties such as density. We use efficient methods to analyze the adsorption and diffusion properties of simple adsorbate molecules in a library of >250,000 hypothetical silica zeolites that was generated previously by Deem and co-workers (J. Phys. Chem. C, 2009, 113, 21353). The properties of this library of materials are compared to the complete set of ∼190 zeolites that have been identified experimentally. Our calculations provide information on the largest cavities available in each material for adsorption, and the size of the largest molecules that can diffuse through each material. For a subset of ∼8000 materials, we computed the Henry's constant and diffusion activation energy for adsorbed CH(4) and H(2). We show that these calculations provide a useful screening tool for considering large collections of nanocrystalline materials and choosing materials with particular promise for more detailed modeling.
Beta-lactam antibiotics functionalized with gem-bisphosphonates. (1999)

Acylation of amoxycillin and cephalexin with acids III, V and VII, and with isocyanate VIII furnished the corresponding beta-lactam antibiotics (X and XIII-XV, respectively). The antibacterial activity of these new antibiotic analogues against Helicobacter pylori was found to be identical with those of amoxycillin, Augmentin, erythromycin and ciprofloxacin.
Toward a severity index for ROP: An unsupervised approach (2016)

Retinopathy of prematurity (ROP) is a disease affecting low birth-weight infants and is the major cause of childhood blindness. Although accurate diagnosis is important, there is a high variability among expert decisions mostly due to subjective thresholds. Existing work focused on automated diagnosis of ROP. In this study, we construct a continuous severity index as an alternative to discrete classification. We follow an unsupervised approach by performing nonlinear dimensionality reduction. Instead of extracting several statistics of image features, each image is represented by the probability distribution of its features. The distance between distributions are then used in manifold learning methods as the distance between samples. The experiments are carried out on a dataset of 104 wide-angle retinal images. The results are promising and they reflect the challenges of the discrete classification.
Predicting Like A Pilot: Dataset and Method to Predict Socially-Aware Aircraft Trajectories in Non-Towered Terminal Airspace (2021)

Pilots operating aircraft in un-towered airspace rely on their situational awareness and prior knowledge to predict the future trajectories of other agents. These predictions are conditioned on the past trajectories of other agents, agent-agent social interactions and environmental context such as airport location and weather. This paper provides a dataset, $\textit{TrajAir}$, that captures this behaviour in a non-towered terminal airspace around a regional airport. We also present a baseline socially-aware trajectory prediction algorithm, $\textit{TrajAirNet}$, that uses the dataset to predict the trajectories of all agents. The dataset is collected for 111 days over 8 months and contains ADS-B transponder data along with the corresponding METAR weather data. The data is processed to be used as a benchmark with other publicly available social navigation datasets. To the best of authors' knowledge, this is the first 3D social aerial navigation dataset thus introducing social navigation for autonomous aviation. $\textit{TrajAirNet}$ combines state-of-the-art modules in social navigation to provide predictions in a static environment with a dynamic context. Both the $\textit{TrajAir}$ dataset and $\textit{TrajAirNet}$ prediction algorithm are open-source. The dataset, codebase, and video are available at https://theairlab.org/trajair/, https://github.com/castacks/trajairnet, and https://youtu.be/elAQXrxB2gw respectively.
Effective Management System for Solar PV Using Real-Time Data with Hybrid Energy Storage System (2020)

This paper proposes an effective management system for stand-alone solar photovoltaic (PV) using real-time data with Hybrid Energy Storage System (HESS). The abrupt movement of fleeting clouds often gives rise to PV power output fluctuations which in turn affect the power quality and system stability due to scattered solar radiation reception. These variations can limit through a ramp-limit controller and employing a DC link controller to maintain the stable DC link voltage. The battery is used in the system for continuous power application and the sudden variations in charging and discharging of battery power can create stress on the battery. These sudden changes in a battery will be removed by the super-capacitor (SC) unit and achieves a fast DC link voltage regulation. Hence, the high energy and power density devices such as battery and SC units will deliver more stable power into the system. The control scheme is tested in Matlab/Simulink and validated by Real-Time Hardware-in-Loop (HIL) simulator using periodic one-minute data for one year from the solar PV power plant from real-time.