gebhart/patrepeval huggingface dataset:
Preoperative Risk-Stratification of High-Risk Prostate Cancer: A Multicenter Analysis (2020)

<b>Background:</b> Cancer-specific survival (CSS) within high-risk non-metastatic prostate cancer varies dramatically. It is likely that within this heterogenous population there are subgroup(s) at extraordinary risk, burdened with an exaptational poor prognosis. Establishing the characteristics of these group(s) would have significant clinical implications since high quality preoperative risk stratification remains the cornerstone of therapeutic decision making to date. <b>Objective:</b> To stratify high-risk prostate cancer based on preoperative characteristics and evaluate cancer specific survival after radical prostatectomy. <b>Method:</b> The EMPaCT multi-center database offers an international population of non-metastatic high-risk prostate cancer. Preoperative characteristics such as age, biopsy Gleason score, PSA and clinical stage were subcategorized. A multivariate analysis was performed using predictors showing significant survival heterogeneity after stratification, as observed by a univariate analysis. Based upon the hazard ratios of this multivariate analysis, a proportional score system was created. The most ideal group distribution was evaluated trough different score cut-off's. The predictive value was tested by the herald C index. <b>Results:</b> An overall 5-years CSS of 94% was noted within the entire high-risk cohort (<i>n</i> = 4,879). Except for age, all preoperative risk factors showed a significantly differing CSS. Multivariate analysis indicated, T4 stage as being the strongest predictor of CSS (HR: 3.31), followed by ISUP grade 5 group (HR 3,05). A score system was created by doubling the hazard ratios of this multivariate analysis and rounding off to the nearest complete number. Multivariate analysis suggested 0, 4, 8, and 12 pts as being the most optimal group distribution (<i>p</i>-value: 0.0015). Five-years CSS of these groups were 97, 93, 87, and 70%, respectively. The calculated Herald C-index of the model was 0.77. <b>Conclusion:</b> An easy-to-use pre-operative model for risk stratification of newly diagnosed high-risk prostate cancer is presented. The heterogeneous CSS of high-risk non-metastatic prostate cancer after radical prostatectomy is illustrated. The model is clinically accessible through an online calculator, presenting cancer specific survival based on individualized patient characteristics.
A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions (1998)

The Ets-1 transcription factor plays a critical role in cell growth and development, but the means by which it activates transcription are still unclear (J. C. Bories, D. M. Willerford, D. Grevin, L. Davidson, A. Camus, P. Martin, D. Stehelin, F. W. Alt, and J. C. Borles, Nature 377:635-638, 1995; N. Muthusamy, K. Barton, and J. M. Leiden, Nature 377:639-642, 1995). Here we show that Ets-1 binds the transcriptional coactivators CREB binding protein (CBP) and the related p300 protein (together referred to as CBP/p300) and that this interaction is required for specific Ets-1 transactivation functions. The Ets-1- and c-Myb-dependent aminopeptidase N (CD13/APN) promoter and an Ets-1-dependent artificial promoter were repressed by adenovirus E1A, a CBP/p300-specific inhibitor. Furthermore, Ets-1 activity was potentiated by CBP and p300 overexpression. The transactivation function of Ets-1 correlated with its ability to bind an N-terminal cysteine- and histidine-rich region spanning CBP residues 313 to 452. Ets-1 also bound a second cysteine- and histidine-rich region of CBP, between residues 1449 and 1892. Both Ets-1 and CBP/p300 formed a stable immunoprecipitable nuclear complex, independent of DNA binding. This Ets-1-CBP/p300 immunocomplex possessed histone acetyltransferase activity, consistent with previous findings that CBP/p300 is associated with such enzyme activity. Our results indicate that CBP/p300 may mediate antagonistic and synergistic interactions between Ets-1 and other transcription factors that use CBP/p300 as a coactivator, including c-Myb and AP-1.
Closo and hyper-closo ten-vertex ruthenacarboranes containing chelating alkenylphosphine ligands (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCloso and hyper-closo ten-vertex ruthenacarboranes containing chelating alkenylphosphine ligandsC. W. Jung, R. T. Baker, C. B. Knobler, and M. F. HawthorneCite this: J. Am. Chem. Soc. 1980, 102, 18, 5782–5790Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://doi.org/10.1021/ja00538a014RIGHTS & PERMISSIONSArticle Views102Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization (2008)

Oligodeoxyfluorosides (ODFs) are a novel system of stacked, electronically interacting fluorophores built on the DNA scaffold. Here we describe early studies of these ODFs as potential universal FRET donors and as reporters of DNA hybridization.
A Comparison of Health Behavior between Rural and Urban in Soonchun City (1999)

The objective of the study was to examine and compare health behavior between rural area and urban area in Soonchun city. Data were collected through personal interviews from 25, April to 30, May in 1998. Questions were asked to the rural area residents(n=399) and urban area residents(n=149) about their health behaviors, including such as self-recognition of health status, health related behaviors(smoking, drinking, eating habit, and exercising), status of disease and prevention, and utilization of hospital. As we examine the demographic characteristics, rural area residents were more aged(p
Observations of layers in ozone vertical profiles from SAGE II (v 6.0) measurements (2002)

Layered structures in the vertical profiles of ozone mixing ratio as retrieved by the Stratospheric Aerosol and Gas Experiment (SAGE II) version 6.0 have been studied in the altitude range 10–28 km in the middle and high latitudes (30–75 N and S). 12 years of data (1985–1990, 1994–1999) have been used to build a climatology of layers with thickness of a few kilometers. The occurrence peaks near 12–13 km, then decreases sharply up to about 20 km before increasing again in the 20–28 km range. The seasonal variation indicates that layering activity maximizes during winter‐spring in both hemispheres. This is similar to earlier results on thinner structures or laminae. A significant number of layers were observed in summer at altitudes &gt;20 km in both hemispheres primarily at high latitudes (&gt;60 N and S).
Confocal enhanced optical coherence tomography for nondestructive evaluation of paints and coatings (1999)

We investigate confocal enhanced optical coherence tomography as a nondestructive evaluation tool for imaging with improved image contrast and depth resolution through a highly scattering paint layer. The depth responses provided by confocal microscopy, optical coherence tomography, and confocal enhanced optical coherence tomography for imaging through paint are investigated. We demonstrate that a new combination of confocal microscopy and optical coherence tomography provides significantly improved resolution and contrast for coherence gated imaging of substrate structures under the paint.
RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes (2019)

Adipose tissue is the key organ coordinating whole-body energy homeostasis. Although it has been reported that ring finger protein 20 (RNF20) regulates lipid metabolism in the liver and kidney, the roles of RNF20 in adipose tissue have not been explored. Here, we demonstrate that RNF20 promotes adipogenesis by potentiating the transcriptional activity of peroxisome proliferator-activated receptor-γ (PPARγ). Under normal chow diet feeding, <i>Rnf20</i> defective (<i>Rnf20</i> <sup><i>+/-</i></sup> ) mice exhibited reduced fat mass with smaller adipocytes compared with wild-type littermates. In addition, high-fat diet-fed <i>Rnf20</i> <sup><i>+/-</i></sup> mice alleviated systemic insulin resistance accompanied by a reduced expansion of fat tissue. Quantitative proteomic analyses revealed significantly decreased levels of PPARγ target proteins in adipose tissue of <i>Rnf20</i> <sup><i>+/-</i></sup> mice. Mechanistically, RNF20 promoted proteasomal degradation of nuclear corepressor 1 (NCoR1), which led to stimulation of the transcriptional activity of PPARγ. Collectively, these data suggest that RNF20-NCoR1 is a novel axis in adipocyte biology through fine-tuning the transcriptional activity of PPARγ.
Units and symbols (2002)

This chapter contains sections titled: The SI units, Physical Constants, Properties of Si, List of Symbols, Prefixes, The ∇ (nabla) symbol, Basic relations for the mathematical operators
Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice (2004)

Deletion of megakaryocytic-specific regulatory sequences of GATA-1 (Gata1(tm2Sho) or GATA-1(low) mutation) results in severe thrombocytopenia, because of defective thrombocytopoiesis, and myelofibrosis. As documented here, the GATA-1(low) mutation blocks megakaryocytic maturation between stage I and II, resulting in accumulation of defective megakaryocytes (MKs) in the tissues of GATA-1(low) mice. The block in maturation includes failure to properly organize alpha granules because von Willebrand factor is barely detectable in mutant MKs, and P-selectin, although normally expressed, is found frequently associated with the demarcation membrane system (DMS) instead of within granules. Conversely, both von Willebrand factor and P-selectin are barely detectable in GATA-1(low) platelets. Mutant MKs are surrounded by numerous myeloperoxidase-positive neutrophils, some of which appear in the process to establish contact with MKs by fusing their membrane with those of the DMS. As a result, 16% (in spleen) to 34% (in marrow) of GATA-1(low) MKs contain 1 to 3 neutrophils embedded in a vacuolated cytoplasm. The neutrophil-embedded GATA-1(low) MKs have morphologic features (high electron density and negativity to TUNEL staining) compatible with those of cells dying from para-apoptosis. We suggest that such an increased and pathologic neutrophil emperipolesis may represent one of the mechanisms leading to myelofibrosis by releasing fibrogenic MK cytokines and neutrophil proteases in the microenvironment.
Photoproduction ofϕ0Mesons from Hydrogen and Carbon by Linearly Polarized Photons (1971)

Results are presented on the forward photoproduction of ${\ensuremath{\phi}}^{0}$ mesons from hydrogen and carbon by linearly polarized photons from coherent bremsstrahlung produced by 10-GeV electrons on a diamond crystal. The polarization asymmetry has been measured at an average energy $〈{E}_{\ensuremath{\phi}}〉=5.7$ GeV. The asymmetry from carbon is consistent with a diffractive production process. The asymmetry from hydrogen seems to be inconsistent with a purely diffractive production process even after consideration of inelastic contributions to the forward ${\ensuremath{\phi}}^{0}$ production.
GWAS in a Box: Statistical and Visual Analytics of Structured Associations via GenAMap (2014)

With the continuous improvement in genotyping and molecular phenotyping technology and the decreasing typing cost, it is expected that in a few years, more and more clinical studies of complex diseases will recruit thousands of individuals for pan-omic genetic association analyses. Hence, there is a great need for algorithms and software tools that could scale up to the whole omic level, integrate different omic data, leverage rich structure information, and be easily accessible to non-technical users. We present GenAMap, an interactive analytics software platform that 1) automates the execution of principled machine learning methods that detect genome- and phenome-wide associations among genotypes, gene expression data, and clinical or other macroscopic traits, and 2) provides new visualization tools specifically designed to aid in the exploration of association mapping results. Algorithmically, GenAMap is based on a new paradigm for GWAS and PheWAS analysis, termed structured association mapping, which leverages various structures in the omic data. We demonstrate the function of GenAMap via a case study of the Brem and Kruglyak yeast dataset, and then apply it on a comprehensive eQTL analysis of the NIH heterogeneous stock mice dataset and report some interesting findings. GenAMap is available from http://sailing.cs.cmu.edu/genamap.
Enzymatic interesterification of tallow‐sunflower oil mixtures (1993)

In an effort to improve the physical and/or thermal characteristics of solid fats, the enzymatic interesterification of tallow and butterfat with high‐oleic sunflower oil and soybean oil was investigated. The two simultaneously occurring reactions, interesterification and hydrolysis, were followed by high‐performance liquid chromatography of altered glycerides and by gas‐liquid chromatography of liberated free fatty acids. The enzymes used in these studies were immobilized lipases that included either a 1,3‐acyl‐selective lipase or a cis ‐9‐C 18 ‐selective lipase. The degree of hydrolysis of the fat/oil mixtures was dependent upon the initial water content of the reaction medium. The extent of the interesterification reaction was dependent on the amount of enzyme employed but not on the reaction temperature over the range of 50–70°C. Changes in melting characteristics of the interesterified glyceride mixtures were followed by differential scanning calorimetry of the residual mixed glycerides after removal of free fatty acids. Interesterification of the glyceride mixes with the two types of enzymes allowed for either a decrease or increase in the solid fat content of the initial glyceride mix.
Investigating an API for resilient exascale computing. (2013)

Increased HPC capability comes with increased complexity, part counts, and fault occurrences. In- creasing the resilience of systems and applications to faults is a critical requirement facing the viability of exascale systems, as the overhead of traditional checkpoint/restart is projected to outweigh its bene ts due to fault rates outpacing I/O bandwidths. As faults occur and propagate throughout hardware and software layers, pervasive noti cation and handling mechanisms are necessary. This report describes an initial investigation of fault types and programming interfaces to mitigate them. Proof-of-concept APIs are presented for the frequent and important cases of memory errors and node failures, and a strategy proposed for lesystem failures. These involve changes to the operating system, runtime, I/O library, and application layers. While a single API for fault handling among hardware and OS and application system-wide remains elusive, the e ort increased our understanding of both the mountainous challenges and the promising trailheads. 3
Convenient preparation of optically active 2-halooctanes and related compounds (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient preparation of optically active 2-halooctanes and related compoundsJoseph San Filippo Jr. and Louis J. RomanoCite this: J. Org. Chem. 1975, 40, 10, 1514–1515Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/jo00898a036https://doi.org/10.1021/jo00898a036research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radical Copolymerization of α,β-Difluoroacrylic Acid with Vinylidene Fluoride. (2010)

The synthesis of α,β-difluoroacrylic acid (FHC═CF−CO2H, DiFAA) and its radical copolymerization with vinylidene fluoride (CH2═CF2, VDF) are presented. First, DiFAA was synthesized in three steps from the radical addition of methanol onto 1,2-dichloro-1,2-difluoroethylene leading to HCFClCFClCH2OH in 78% yield. Then, oxidation of the hydroxymethyl end-group followed by zinc-mediated dehalogenation of 2,3-dichloro-2,3-difluoropropanoic acid led to (Z) isomer of DiFAA in 29% overall yield. The homopolymerization of DiFAA was successfully achieved by radical polymerization initiated by tert-butylperoxypivalate (TBPPi) at 74 °C in 32% yield. Its radical copolymerization with VDF was carried out for the first time and at various compositions leading to functional poly(VDF). The resulting poly(VDF-co-DiFAA) copolymers, characterized by 1H and 19F NMR spectroscopies, exhibited a statistic microstructure. The kinetics of this radical copolymerization led to the assessment of the reactivity ratios (rDiFAA = 0.86 and rVDF = 0.34 at 74 °C), and showed that DiFAA was more reactive than VDF in copolymerization. Thermal properties of these poly(DiFAA-co-VDF) copolymers were also investigated. Differential scanning calorimetry analyses showed a decrease of the glass transition temperature (Tg) with increasing VDF content. Calculations using the Fox’s equation led to the determination of the Tg for poly(DiFAA) homopolymer (Tg = 145 °C) in good agreement with the literature. Thermogravimetric analyses displayed increased thermostability of the resulting copolymers with increasing VDF content.
Self-supported branched poly(ethyleneimine) materials for CO2 adsorption from simulated flue gas (2019)

A family of self-supported, cross-linked PEI materials is demonstrated as promising CO<sub>2</sub> adsorbents, displaying (i) good CO<sub>2</sub> capacity (ii) rapid uptake kinetics, and (iii) good stability relative to conventional supported amine adsorbents.
Rb and N- ras Function Together To Control Differentiation in the Mouse (2003)

The product of the retinoblastoma tumor suppressor gene (Rb) can control cell proliferation and promote dif-ferentiation. Murine embryos nullizygous for Rb die midgestation with defects in cell cycle regulation, control of apoptosis, and terminal differentiation of several tissues, including skeletal muscle, nervous system, and lens. Previous cell culture-based experiments have suggested that the retinoblastoma protein (pRb) and Ras operate in a common pathway to control cellular differentiation. Here we have tested the hypothesis that the proto-oncogene N-ras participates in Rb-dependent regulation of differentiation by generating and characterizing murine embryos deficient in both N-ras and Rb. We show that deletion of N-ras rescues a unique subset of the developmental defects associated with nullizygosity of Rb, resulting in a significant extension of life span. Rb(−/−); N-ras(−/−) skeletal muscle has normal fiber density, myotube length and thickness, in contrast to Rb-deficient embryos. Additionally, Rb(−/−); N-ras(−/−) muscle shows a restoration in the expression of the late muscle-specific gene MCK, and this correlates with a significant potentiation of MyoD transcriptional activity in Rb(−/−); N-ras(−/−), compared to Rb(−/−) myoblasts in culture. The improved differentiation of skeletal muscle in Rb(−/−); N-ras(−/−) embryos occurs despite evidence of deregulated proliferation and apoptosis, as seen in Rb-deficient animals. Our findings suggest that the control of differentiation and proliferation by Rb are genetically separable.
Gel Polymer Electrolytes Based on Cross-Linked Poly(ethylene glycol) Diacrylate for Calcium-Ion Conduction (2021)

Calcium batteries are promising alternatives to lithium batteries owing to their high energy density, comparable reduction potential, and mineral abundance. However, to meet practical demands in high-performance applications, suitable electrolytes must be developed. Here, we report the synthesis and characterization of polymer gel electrolytes for calcium-ion conduction prepared by the photo-cross-linking of poly(ethylene glycol) diacrylate (PEGDA) in the presence of solutions of calcium salts in a mixture of ethylene carbonate (EC) and propylene carbonate (PC) solvents. The results show room-temperature conductivity between 10<sup>-5</sup> and 10<sup>-4</sup> S/cm, electrochemical stability windows of ∼3.8 V, full dissociation of the salt, and minimal coordination with the PEGDA backbone. Cycling in symmetric Ca metal cells proceeds but with increasing overpotentials, which can be attributed to interfacial impedance between the electrolyte and calcium surface, which inhibits charge transfer. Calcium may still be plated and stripped yielding high-purity deposits and no indication of significant electrolyte breakdown, indicating that high overpotentials are associated with an electrically insulating, yet ion-permeable solid electrolyte interface (SEI). This work provides a contribution to the study and understanding of polymer gel materials toward their improvement and application as electrolytes for calcium batteries.