gebhart/patrepeval huggingface dataset:
Complete Genome Sequences of Three Shiga Toxin-Producing Escherichia coli O111:H8 Strains Exhibiting an Aggregation Phenotype (2019)

Non-O157 Shiga toxin-producing Escherichia coli (STEC) strains are a common source of foodborne illness. STEC O111 is among the most prevalent non-O157 STEC serogroups. Few completed genomes of STEC O111 strains have been reported to date. We report here the complete genomic sequences of three O111:H8 strains that display a distinct aggregation phenotype.
Designing and implementing a biobanking IT framework for multiple research scenarios (2012)

This paper presents a biobanking IT framework, comprising a set of integrated biobanking information technology components. It provides adaptable and scalable IT support for varying biobanking scenarios, workflows and projects, while avoiding redundancy in data and technology. Feasibility of this approach is illustrated by implementations for four different biobanking projects at Erlangen University Hospital and with cooperating partners in Münster and Lübeck.
Fine structure in thePb208photoneutron cross section between 9.9 and 11.2 MeV (1982)

The partial differential photoneutron cross sections for $^{208}\mathrm{Pb}$ were measured in the energy region from 9.9 to 11.2 MeV with an energy resolution of about 100 keV. Neutrons leaving $^{207}\mathrm{Pb}$ in its ground state and first two excited states were resolved, and angular distributions were determined from measurements at seven angles from 45\ifmmode^\circ\else\textdegree\fi{} to 135\ifmmode^\circ\else\textdegree\fi{}. These data provide more information about the fine structure observed in earlier, poorer resolution measurements of the total photoneutron cross section and strongly support the interpretation of this structure as being due to electric dipole excitations. The measured partial cross sections provide a sensitive test for models attempting to describe the photon interaction cross section and the coupling of the excited states to the continuum. Calculations using a statistical model with transmission coefficients obtained from a conventional optical model are unable to explain even the average behavior of the branching ratios with energy. The measured angular distributions show clear evidence for interference of either $E2$ or $M1$ processes with the predominant $E1$ interaction. The interference terms have a magnitude approximately equal to that predicted by a simple direct-semidirect calculation including the electric dipole and isoscalar electric quadrupole giant resonance. However, this agreement is puzzling because the average of interferences between the many compound nuclear levels in this region of excitation would be expected to reduce anisotropies about 90\ifmmode^\circ\else\textdegree\fi{} toward zero.NUCLEAR REACTIONS $^{208}\mathrm{Pb}$($\ensuremath{\gamma}$,$n$), $E=9.9\ensuremath{-}11.2$ MeV; tagged photon resolution 120 keV; measured $\ensuremath{\sigma}({E}_{n},\ensuremath{\theta})$, $\ensuremath{\theta}=45\ifmmode^\circ\else\textdegree\fi{}\ensuremath{-}135\ifmmode^\circ\else\textdegree\fi{}$; observed interference of either $E2$ or $M1$ with $E1$.
Measurement of reactance of synchronous machines at standstill (2003)

When feasible, testing high power synchronous machines in a classical steady state regime requires a great deal of electrical power. This paper presents a method and its implementation for testing electrical machines in transient regimes, aiming at the reduction of the required power and minimization of the testing time. The direct-axis and quadrature-axis reactances are indirectly found by processing the acquired digitized samples of the step response of the stator current of a locked-rotor synchronous machine. Experimental results that have been obtained in a series of formal tests, illustrates the large applicability of this method.
Spray production by air bubbles bursting on a water surface (1999)

The size and two components of the ejection velocity of the jet droplets generated by bursting bubbles on a water surface have been measured by a phase Doppler particle analyzer. The experiments are for bubbles of diameters in the range 200–1000 μm, which produced drops in the range of 10–150 μm. A careful analysis of raw data allowed the top and second jet drop velocities at the ejection position to be derived. These data agree well with previous measurements and show very good consistency for data taken at distances of 3, 18.5, and 30 mm from the water surface. The analysis of data for the horizontal component of the ejection velocity shows that the mean value of the ejection angle (inclination with respect to the vertical) for droplets in the most populated size band (50–60 μm) is ∼8°–9° and increases with droplet size.
Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector (2010)

The development of transgenic technologies in monkeys is important for creating valuable animal models of human physiology so that the etiology of diseases can be studied and potential therapies for their amelioration may be developed. However, the efficiency of producing transgenic primate animals is presently very low, and there are few reports of success. We have developed an improved methodology for the production of transgenic rhesus monkeys, making use of a simian immunodeficiency virus (SIV)-based vector that encodes EGFP and a protocol for infection of early-cleavage-stage embryos. We show that infection does not alter embryo development. Moreover, the timing of infection, either before or during embryonic genome activation, has no observable effect on the level and stability of transgene expression. Of 70 embryos injected with concentrated virus at the one- to two-cell stage or the four- to eight-cell stage and showing fluorescence, 30 were transferred to surrogate mothers. One transgenic fetus was obtained from a fraternal triple pregnancy. Four infant monkeys were produced from four singleton pregnancies, of which two expressed EGFP throughout the whole body. These results demonstrate the usefulness of SIV-based lentiviral vectors for the generation of transgenic monkeys and improve the efficiency of transgenic technology in nonhuman primates.
All-digital differential VCO-based A/D conversion (2010)

Voltage-controlled oscillator-based analog-to-digital converters utilizes the superior time resolution and digital processing power of time-domain signal processing. With its inherent first-order noise shaping property, very high accuracy can be obtained while reducing both area and power consumption. An all-digital VCO-based ADC scheme is presented which combines a differential configuration with digital calibration to obtain very high linearity. A coarse-fine quantization approach is used to reduce the circuit complexity compared to the traditional multi-bit quantization The phase resolution is increased using passive interpolation coupled VCOs. These techniques are illustrated with a 65 nm CMOS implementation of a 30 MHz BW 10-bit ADC, occupying only 0.023 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
A resource-driven DVFS scheme for smart handheld devices (2013)

Reducing the energy consumption of the emerging genre of smart handheld devices while simultaneously maintaining mobile applications and services is a major challenge. This work is inspired by an observation on the resource usage patterns of mobile applications. In contrast to existing DVFS scheduling algorithms and history-based prediction techniques, we propose a resource-driven DVFS scheme in which resource state machines are designed to model the resource usage patterns in an online fashion to guide DVFS. We have implemented the proposed scheme on Android smartphones and conducted experiments based on real-world applications. The results are very encouraging and demonstrate the efficacy of the proposed scheme.
Phosphoproteomics Identified an NS5A Phosphorylation Site Involved in Hepatitis C Virus Replication (2015)

The non-structural protein 5A (NS5A) is a hepatitis C virus (HCV) protein indispensable for the viral life cycle. Many prior papers have pinpointed several serine residues in the low complexity sequence I region of NS5A responsible for NS5A phosphorylation; however, the functions of specific phosphorylation sites remained obscure. Using phosphoproteomics, we identified three phosphorylation sites (serines 222, 235, and 238) in the NS5A low complexity sequence I region. Reporter virus and replicon assays using phosphorylation-ablated alanine mutants of these sites showed that Ser-235 dominated over Ser-222 and Ser-238 in HCV replication. Immunoblotting using an Ser-235 phosphorylation-specific antibody showed a time-dependent increase in Ser-235 phosphorylation that correlated with the viral replication activity. Ser-235 phosphorylated NS5A co-localized with double-stranded RNA, consistent with its role in HCV replication. Mechanistically, Ser-235 phosphorylation probably promotes the replication complex formation via increasing NS5A interaction with the human homologue of the 33-kDa vesicle-associated membrane protein-associated protein. Casein kinase Iα (CKIα) directly phosphorylated Ser-235 in vitro. Inhibition of CKIα reduced Ser-235 phosphorylation and the HCV RNA levels in the infected cells. We concluded that NS5A Ser-235 phosphorylated by CKIα probably promotes HCV replication via increasing NS5A interaction with the 33-kDa vesicle-associated membrane protein-associated protein.
Tungsten metallization onto InP prepared by rapid thermal low-pressure chemical vapor deposition of WF6 and H2 (1992)

Tungsten (W) films were deposited onto InP in a cold wall, rapid thermal low-pressure chemical vapor deposition (RT-LPCVD) reactor, using a tungsten hexafluoride (WF6) gas reduced by hydrogen (H2). W films of thickness 50–450 nm were deposited in the temperature range of 350–550 °C, pressure range of 0.5–4.5 Torr, and deposition rates up to 4 nm/s with an apparent activation energy of about 1.12 eV. The film stress varied depending on the deposition pressure, from low compressive (deposition at 0.5 Torr) to moderate tensile (deposition at about 4.5 Torr). Post-deposition sintering of the W films at temperatures up to 600 °C led to reduction of the resistivity with a minimum value of about 55 μΩ cm as a result of heating at 500 °C.
Interference-driven resource management for GPU-based heterogeneous clusters (2012)

GPU-based clusters are increasingly being deployed in HPC environments to accelerate a variety of scientific applications. Despite their growing popularity, the GPU devices themselves are under-utilized even for many computationally-intensive jobs. This stems from the fact that the typical GPU usage model is one in which a host processor periodically offloads computationally intensive portions of an application to the coprocessor. Since some portions of code cannot be offloaded to the GPU (for example, code performing network communication in MPI applications), this usage model results in periods of time when the GPU is idle. GPUs could be time-shared across jobs to "fill" these idle periods, but unlike CPU resources such as the cache, the effects of sharing the GPU are not well understood. Specifically, two jobs that time-share a single GPU will experience resource contention and interfere with each other. The resulting slow-down could lead to missed job deadlines. Current cluster managers do not support GPU-sharing, but instead dedicate GPUs to a job for the job's lifetime.
Inhibition of the Lytic Effect of Guinea Pig Complement by Rabbit Complement (1969)

Summary A sensitized target cell, either a rat peritoneal mast cell or a sheep erythrocyte, when exposed to normal rabbit complement or heat-inactivated rabbit complement, becomes resistant to lysis by guinea pig complement. The inhibition of lysis observed by pretreatment of sensitized sheep erythrocytes with rabbit complement is due to a functional incompatibility between the EAC1ra4ra intermediate that is generated, and C2gp either functionally pure or in guinea pig complement. The second inhibitory mechanism, produced by heat-inactivated rabbit complement, is due to the action of an altered form of C1ra which retains its binding capacity for the sensitized site but is lytically unreactive.
Low probability of detection underwater acoustic communications for mobile platforms (2008)

Mobile underwater platforms, such as autonomous underwater vehicles (AUVs), use underwater acoustic communications to form a network for command and control. Direct sequence spread spectrum signaling can be used for multi-access communications. It also provides high processing gain for communications using a low source level. Probability of detection by an intruder is minimized due to the decreased signal-to-noise ratio outside the operation area. A simple receiver algorithm is presented for DSSS communications between mobile platforms in the presence of multipaths. This paper analyzes the required source level for a given operating area and the corresponding counter detection range by a intruder.
Use of RAFT macro-surfmers for the synthesis of transparent aqueous colloids with tunable interactions (2017)

We propose a new method to produce fluorinated nanoparticles (NPs) based on ab initio reversible addition-fragmentation chain transfer (RAFT) emulsion polymerization without the use of toxic surfactants. NP size, surface charge, and chemistry can be controlled via the adoption of different macromolecular transfer agents produced via RAFT polymerization of amphiphilic monomers. Thanks to this versatility, interparticle interactions can be easily tuned by changing solvent composition and temperature. In addition, the refractive index and density of the solvent can simultaneously match those of the NPs by adding sodium polytungstate, an organic salt widely used for density gradient centrifugation. These colloids may be used as model systems for the study of self-assembly and aggregation in aqueous media when optical methods are required.
Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model (2004)

These results demonstrate that treatment with taurine reduces iron-mediated myocardial oxidative stress, preserves cardiovascular function, and improves survival in iron-overloaded mice. The role of taurine in protecting reduced glutathione levels provides an important mechanism by which oxidative stress-induced myocardial damage can be curtailed. Taurine, as a dietary supplement, represents a potential new therapeutic agent to reduce the cardiovascular burden from iron-overload conditions.
Comparison of IVIg and PLEX in patients with myasthenia gravis (2011)

This study provides Class I evidence that IVIg and PLEX have comparable efficacy and are equally tolerated in adult patients with moderate to severe MG within 2 weeks of treatment.
Short Term Load Forecasting of Offshore Oil Field Microgrids Based on DA-SVM (2019)

Prediction accuracy is a basic indicator for short-term load forecasting, which is particularly crucial for the microgrid of offshore oilfield groups. A method of support vector machine based on the dragonfly algorithm (DA-SVM) is proposed to predict the short-term load of the microgrid in an offshore oil field. This method combines the penalty factor and kernel function of support vector machine as the solution position of dragonfly. The prediction accuracy of the algorithm is employed as the current fitness value of dragonfly. The optimal location of the dragonfly is the optimal parameters of the support vector machine. The DA-SVM algorithm was used to predict the short-term load of an offshore oil field microgrid in the Bohai sea, China, and is compared with the prediction of PSO-SVM, GA-SVM and BPNN models. The results show that the DA-SVM algorithm has more straightforward steps, better global search ability, higher prediction accuracy and better computing speed.
Discovering trends in software engineering with google trend (2007)

Trends are a valuable tool to shape one's research, decide on acquisitions, inform about technologies or standards used in the development process. Google Trends is a new service by Google for researching the amount of searches and news articles collected by their search engines, which can be used to discover trends in software engineering. In May 2006 Google Trends was opened to the public to support researching trends based on searches to Google Search and news articles collected in Google News. This short paper shows how information from Google Trend can be used to analyze media attention, search interests, and cause-effect relations of one topic or between multiple topics such as technologies, tools, or methodologies.
Pes cavovarus. Review of a surgical approach using selective soft-tissue procedures. (1980)

This study reviews the surgical treatment of twenty-seven patients (thirty-nine feet) with cavovarus foot deformity. The patients' ages ranged from six months to fifteen years. Only those patients who had at least a two-year follow-up were selected for statistical analysis. This group comprised twenty patients (twenty-seven feet). A standardized treatment program was used, based on the flexibility of the deformity. A radical plantar or plantar medial release was employed as indicated, in combination with tendon transfers or osteotomy of the fore part of the foot, or both. All patients were available for follow-up examination and special roentgenograms of the hind part of the foot. Follow-up appraisal of the patients with more than two years' follow-up revealed more than 85 per cent acceptable results with no major complications.
Reduced models and design principles for half-harmonic generation in synchronously pumped optical parametric oscillators (2016)

We develop reduced models that describe half-harmonic generation in a synchronously pumped optical parametric oscillator above threshold, where nonlinearity, dispersion, and group-velocity mismatch are all relevant. These models are based on (1) an eigenmode expansion for low pump powers, (2) a simultonlike sech-pulse ansatz for intermediate powers, and (3) dispersionless box-shaped pulses for high powers. Analytic formulas for pulse compression, degenerate vs nondegenerate operation, and stability are derived and compared to numerical and experimental results.
Integrating NAND flash devices onto servers (2009)

Flash is a widely used storage device in portable mobile devices such as smart phones, digital cameras, and MP3 players. It provides high density and low power, properties that are appealing for other computing domains. In this paper, we examine its use in the server domain. Wear-out has the potential to limit the use of Flash in this domain. To seriously consider Flash in the server domain, architectural support must exist to address this lack of reliability. This paper first provides a survey of current and potential Flash usage models in a data center. We then advocate using Flash as an extended system memory usage model---OS managed disk cache---and describe the necessary architectural changes. Specifically we propose two key changes. The first improves performance and reliability by splitting Flash-based disk caches into separate read and write regions. The second improves reliability by employing a programmable Flash memory controller. It changes the error code strength (number of correctable bits) and the number of bits that a memory cell can store (cell density) in response to the demands of the application.
Likelihood Estimation for Reduced-Complexity ML Detectors in a MIMO Spatial-Multiplexing System (2008)

This paper proposes a likelihood estimation method for reduced-complexity maximum-likelihood (ML) detectors in a multiple-input multiple-output (MIMO) spatial-multiplexing (SM) system. Reduced-complexity ML detectors, e. g., Sphere Decoder (SD) and QR decomposition (QRD)-M algorithm, are very promising as MIMO detectors because they can estimate the ML or a quasi-ML symbol with very low computational complexity. However, they may lose likelihood information about signal vectors having the opposite bit to the hard decision and bit error rate performance of the reduced-complexity ML detectors are inferior to that of the ML detector when soft-decision decoding is employed. This paper proposes a simple estimation method of the lost likelihood information suitable for the reduced-complexity ML detectors. The proposed likelihood estimation method is applicable to any reduced-complexity ML detectors and produces accurate soft-decision bits. Computer simulation confirms that the proposed method provides excellent decoding performance, keeping the advantage of low computational cost of the reduced-complexity ML detectors.
Is the mechanical power the final word on ventilator-induced lung injury?—we are not sure (2018)

It may be hard to argue against the thesis that mechanical ventilation represents one of the most important treatments ever introduced in the care of patients with respiratory failure. Similarly to other supportive measures adopted in intensive care (e.g., renal replacement therapy, extracorporeal supports, etc.), mechanical ventilation—replacing partially or totally the insufficient respiratory muscles—“buys time” until a causal therapy (if available) becomes effective, the lung heals and the patient recuperates respiratory and breathing autonomy.
Combination peptide immunotherapy based on T‐cell epitope mapping reduces allergen‐specific IgE and eosinophilia in allergic airway inflammation (2012)

Peptide immunotherapy using soluble peptides containing allergen-derived immunodominant T-cell epitopes holds therapeutic promise for allergic asthma. Previous studies in BALB/c mice using the immunodominant peptide epitope of chicken ovalbumin (p323-339) have been unable to demonstrate therapeutic effects in ovalbumin-induced allergic airway inflammation. We have previously shown that intravenous application of p323-339 can effectively tolerise p323-339-reactive T cells in a non-allergic model in C57BL/6 mice. This study aimed to assess the effects of using p323-339 immunotherapy in a C57BL/6 model of ovalbumin-induced allergic airway inflammation, identify any additional epitopes recognized by the ovalbumin-responsive T-cell repertoire in C57BL/6 mice and assess the effects of combination peptide immunotherapy in this model. Ovalbumin-reactive T-cell lines were generated from ovalbumin-immunized C57BL/6 mice and proliferative responses to a panel of overlapping peptides covering the ovalbumin sequence were assessed. Soluble peptides (singly or combined) were administered intravenously to C57BL/6 mice before the induction of ovalbumin-induced allergic airway inflammation. Peptide immunotherapy using the 323-339 peptide alone did not reduce the severity of allergic airway inflammation. An additional immunodominant T-cell epitope in ovalbumin was identified within the 263-278 sequence. Combination peptide immunotherapy, using the 323-339 and 263-278 peptides together, reduced eosinophilia in the bronchoalveolar lavage and ovalbumin-specific IgE, with apparent reductions in interleukin-5 and interleukin-13. Characterization of the T-cell response to a model allergen has allowed the development of combination peptide immunotherapy with improved efficacy in allergic airway inflammation. This model holds important potential for future mechanistic studies using peptide immunotherapy in allergy.