gebhart/patrepeval huggingface dataset:
K. N. Nicholson, 1993. Geothermal Fluids. Chemistry and Exploration Techniques. xv + 263 pp. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong: Springer-Verlag. Price DM 138.00, Ös 1076.40, SFr 138.00 (hard covers). ISBN 3 540 56017 3. (1995)

K. N. Nicholson, 1993. Geothermal Fluids. Chemistry and Exploration Techniques. xv + 263 pp. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong: Springer-Verlag. Price DM 138.00, Ös 1076.40, SFr 138.00 (hard covers). ISBN 3 540 56017 3. - Volume 132 Issue 1
Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReceptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptideMark G. Bock, R. M. DiPardo, P. D. Williams, D. J. Pettibone, B. V. Clineschmidt, R. G. Ball, D. F. Veber, and R. M. FreidingerCite this: J. Med. Chem. 1990, 33, 9, 2321–2323Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/jm00171a003https://doi.org/10.1021/jm00171a003research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of EEG Data Acquisition System Based on FPGA Zedboard (2017)

An Electroencephalography (EEG) data acquisition system based on FPGA Zedboard (Diligent, USA) has been implemented using ADC (Analog to Digital Converter) front-end ADS1299FE (Texas Instrument, USA). The EEG instrument is a device used to measure the electrical brain activities on the scalp, and the voltage potential of EEG signal around 0.5-100μV with frequency 0.5 - 40 Hz. The data acquisition system has been configured with 2-chips ADS1299 Daisy-Chain mode and processing based on Zedboard FPGA. The data acquisition system was used with FPGA, because that is very powerful speed to acquire the ADC devices. The result of data acquisition system has been sent to PC (Personal Computer) and also displayed into the graphic format of EEG data. The EEG instrument has been successfully validated using EEG Simulator (NETECH Mini-Sim EEG) with frequency 2Hz, 5Hz, and also voltage tested in 30 uV, 50 uV and 100 uV. The validation result at 2Hz was obtained measurement with a maximum deviation average of 0.15uV, therefore frequency of 5Hz with a maximum deviation average of 0.18uV.
PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity (2022)

Abstract Oxygen is critical for all metazoan organisms on the earth and impacts various biological processes in physiological and pathological conditions. While oxygen sensing systems inducing acute hypoxic response, including HIF pathway, have been identified, those operating in prolonged hypoxia remain to be elucidated. Here, we show that pyridoxine 5’-phosphate oxidase (PNPO) that catalyzes bioactivation of vitamin B6 serves as an oxygen sensor and regulates lysosomal activity in macrophages. Decline of PNPO activity under prolonged hypoxia reduced an active form of vitamin B6, pyridoxal 5’-phosphate (PLP), and inhibited lysosomal activity, leading to the augmentation of inflammatory response of macrophages. The PNPO-PLP axis creates a distinct layer of oxygen sensing, which gradually turns down and up the PLP-dependent metabolism according to prolonged changes in oxygen availability.
Numerical Simulation of Mechanical Alloying in a Shaker Mill by Discrete Element Method (2005)

Modeling of Mechanical Alloying (MA), which is a solid-state powder processing technique, is carried out by examining one widely used laboratory scale milling device, the SPEX 8000 shaker mill. It is a vibratory mill; its vial is agitated at a high frequency in a complex cycle that involves motion in three orthogonal directions. In this work, a popular dynamic simulation technique, Discrete Element Modeling, is applied to examine dynamics of a SPEX 8000 shaker ball mill based on the movement of milling balls. The computational results for energy dissipation rate inside the mill are calculated for different ball sizes and varied total ball to powder mass ratios (charge ratios). The computational results are well correlated with the experimental results tracking milling dose (used to define the degree of milling) as a function of ball sizes and charge ratios. Moreover, the numerical (theoretical) milling dose that correlates well with its experimental analog was found to depend on the energy dissipation rate of the head-on ball collisions. The numerical simulations also indicated that the milling progress is most significantly affected by milling media collisions with the energy within a specific threshold, while the collisions with smaller and greater energies are less effective. Finally, discussion shows how this novel approach of correlating specific scaling terms between experiments and simulations can be applied to other powder processing equipment.
Figure S1 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP (2023)

&lt;p&gt;IMA and 08-0537 Cloning Supplementary Data&lt;/p&gt;
THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes (2021)

Mechanisms controlling myelination during central nervous system (CNS) maturation play a pivotal role in the development and refinement of CNS circuits. The transcription factor THAP1 is essential for timing the inception of myelination during CNS maturation through a cell-autonomous role in the oligodendrocyte lineage. Here, we demonstrate that THAP1 modulates the extracellular matrix (ECM) composition by regulating glycosaminoglycan (GAG) catabolism within oligodendrocyte progenitor cells (OPCs). <i>Thap1</i><sup>-/-</sup> OPCs accumulate and secrete excess GAGs, inhibiting their maturation through an autoinhibitory mechanism. THAP1 controls GAG metabolism by binding to and regulating the <i>GusB</i> gene encoding β-glucuronidase, a GAG-catabolic lysosomal enzyme. Applying GAG-degrading enzymes or overexpressing β-glucuronidase rescues <i>Thap1</i><sup>-/-</sup> OL maturation deficits in vitro and in vivo. Our studies establish lysosomal GAG catabolism within OPCs as a critical mechanism regulating oligodendrocyte development.
Enfoque del anciano frágil con estenosis aórtica severa (2019)

La estenosis aórtica es la valvulopatía más común, su prevalencia aumenta de forma marcada con la edad y representa una importante causa de morbilidad y mortalidad en el anciano. Por tal motivo se ha implementado un nuevo procedimiento llamado: técnica de implantación valvular aórtica transcatéter (TAVI), que ha mostrado resultados superiores a la terapia médica en pacientes no aptos para la cirugía. El TAVI es el procedimiento preferido en pacientes con estenosis aórtica severa (EAS) que presentan alto riesgo de morbimortalidad, en los que una cirugía tradicional implica alto riesgo o que son etiquetados como inoperables. Este procedimiento a pesar de los beneficios que conlleva a los pacientes, puede generar complicaciones, principalmente acceso vascular, accidentes cerebrovasculares secundarios al procedimiento e insuficiencia aórtica post implante.&#x0D; La fragilidad en el anciano representa del 7 al 20% aproximadamente; este factor de riesgo resulta importante pues se ha asociado con el aumento de morbilidad y mortalidad en pacientes que han sido sometidos a TAVI.
Multiple angle viewer for remote medical training (2010)

We present the design of an interface for a camera array that will enable mentoring and monitoring of dissections and surgical procedures for medical instructors and students. While considerable research has investigated the recording and broadcasting of surgical procedures and dissection sessions for medical instruction, little work has been reported on the integration of an interface able to display multiple viewpoints within a medical context. The interface presented here allows a designated individual, the instructor, to provide the best viewing point to observe and execute a procedure, and simultaneously, offers the remote viewer the freedom to change viewpoints.
Silylium-Ion-Promoted Ring-Opening Hydrosilylation and Disilylation of Unactivated Cyclopropanes (2020)

A silylium-ion-promoted ring-opening hydrosilylation of unactivated cyclopropanes is reported. The reaction is facilitated by the γ-silicon effect, and the regioselectivity is influenced by various stabilizing effects on the carbenium-ion intermediates, including the β-silicon effect. The experimental observations are in accord with the computed reaction mechanism. The work also showcases the ability of silylium ions to isomerize cyclopropyl to allyl groups, and the resulting α-olefins engage in a silylium-ion-mediated disilylation with hexamethyldisilane.
Multi-vendor evaluation of artificial intelligence as an independent reader for double reading in breast cancer screening on 275,900 mammograms (2023)

ISRCTN18056078 (20/03/2019; retrospectively registered).
Analytical and technical aspects of free discharge end ofplasma pencil (2016)

Plasma pencil has been employed as an alternative excitation
source for atomic emission spectroscopy determination of
elemental contents in solutions [1, 2]. The new arrangement of
the discharge tube enables to measure spectra from the free
discharge end without shielding by the quartz wall. Most
intensive atomic spectra can be recorded as close as possible
to the ground electrode but it is also possible to record the
plasma tip radiation in the range of about 0-10 mm from the
ground electrode or as long as the discharge tip is formed
behind the ground electrode. The pencil sustainability and
stability were tested under various operating conditions.
Carrier gas and plasma gas flow rates as well as forwarded
power were changed and spectra of selected elements were
recorded in order to yield best signal to backgroud ratio and
discharge stability. It has been found that intensities of some
atomic lines increase with decreasing plasma gas flow rate,
increasing carrier gas flow rate and slightly with increasing
forwarded power up to 180 W in continuous mode. The pulsed mode
has not been tested [2]. As in our previous studies elements of
first two groups of the periodic table, zinc and copper were
tested. In some cases the sensitivity increased by one order of
magnitude. Calibration dependences in the range of 0.1 – 10 mg
× L-1 were then measured. Also matrix effects similar to those
in the previous arrangement were observed. On the other hand,
electronic excitation temperature from argon atomic lines,
rotational temperature from OH lines and electron number
density do not significantly change as a result of mixing argon
with ambient air. Matrix effects by alkali salts were also
observed but not eliminated under any operating conditions.
Preliminary experiments rather show that the relative decrease
of the analyte lines intensities in presence of an alkali salt
is preserved.
Technological Approaches for the Reduction of Microplastic Pollution in Seawater Desalination Plants and for Sea Salt Extraction (2019)

An increasingly serious and widespread problem is the introduction of plastics into the water cycle. The poor degradability leads to the plastic waste remaining in water for a long time and over time it fragments into smaller and smaller plastic particles. Both the visible plastic parts and in particular their decomposition products and functionalized plastic particles are an enormous burden. Seawater desalination and sea salt extraction are highly dependent on the quality of the seawater in terms of process utilization and cost structures, i.e., on the level of pollution. Especially microparticles represent a significant potential for blocking the microfiltration membranes (pore size &gt; 100 nm) in the pretreatment and the very costly reverse osmosis (RO) membranes (pore size &gt; 5 nm). An innovative approach for the removal of microplastics from industrially used seawater combines a chemically induced agglomeration and a new technological implementation step. The particular challenge in removing the synthetic impurities is not only their small size but also their inert properties against most of the physical and chemical additives for flocculation. With an easy implementation to existing systems, an economic aspect and a strong impact on the maritime ecological balance will be expected.
Measuring Cognitive Distraction in the Automobile III: A Comparison of Ten 2015 In-Vehicle Information Systems (2015)

This research examined the impact of In-Vehicle Information System (IVIS) interactions on the driver’s cognitive workload. Two hundred fifty-seven subjects participated in a weeklong evaluation of the IVIS interaction in one of 10 different model-year 2015 automobiles. After an initial assessment of the cognitive workload associated with using the IVIS, participants took the vehicle home for five days and practiced using the system. At the end of the five days of practice, participants returned and the workload of these IVIS interactions was reassessed. The cognitive workload was found to be moderate to high, averaging 3.34 on a 5-point scale and ranged from 2.37 to 4.57. The workload was associated with the intuitiveness and complexity of the system and the time it took participants to complete the interaction. The workload experienced by older drivers was significantly greater than that experienced by younger drivers performing the same operations. Practice did not eliminate the interference from IVIS interactions. In fact, IVIS interactions that were difficult on the first day were still relatively difficult to perform after a week of practice. Finally, there were long-lasting residual costs after the IVIS interactions had terminated. The higher levels of workload should serve as a caution that these voice-based interactions can be cognitively demanding and ought not to be used indiscriminately while operating a motor vehicle.
Quantitative Determination of Hydroxy Pentacyclic Triterpene Acids in Vegetable Oils (1999)

A simple and precise analytical method for the determination of hydroxy pentacyclic triterpene acids (HPTAs) in vegetable oils was developed. The acidic fraction was isolated by solid-phase extraction using bonded aminopropyl cartridges, and the extract was silylated and analyzed by gas chromatography. Repeatability and recovery of the method were determined. In virgin olive oils, similar amounts of oleanolic (3beta-hydroxyolean-12-en-28-oic) and maslinic (2alpha,3beta-dihydroxyolean-12-ene-28oic) acids and traces of ursolic (3beta-hydroxyurs-12-en-28-oic) acid were found. The main factor affecting HPTA concentration was the oil quality since that increases as the quality decreases, while olive variety, olive ripeness, and oil extraction system had less influence. In crude olive pomace oils, the concentrations were very much higher than in virgin olive oils. During refining processes, total or significant losses of HPTAs were observed. Esterified derivatives of HPTAs were not found.
Nanotube Networks in Polymer Nanocomposites:  Rheology and Electrical Conductivity (2004)

Single-walled carbon nanotube (SWNT)/poly(methyl methacrylate) (PMMA) nanocomposites were prepared via our coagulation method providing uniform dispersion of the nanotubes in the polymer matrix. Optical microscopy, Raman imaging, and SEM were employed to determine the dispersion of nanotube at different length scales. The linear viscoelastic behavior and electrical conductivity of these nanocomposites were investigated. At low frequencies, G' becomes almost independent of the frequency as nanotube loading increases, suggesting an onset of solidlike behavior in these nanocomposites. By plotting G' vs nanotube loading and fitting with a power law function, the rheological threshold of these nanocomposites is ∼0.12 wt %. This rheological threshold is smaller than the percolation threshold of electrical conductivity, ∼0.39 wt %. This difference in the percolation threshold is understood in terms of the smaller nanotube−nanotube distance required for electrical conductivity as compared to that required to impede polymer mobility. Furthermore, decreased SWNT alignment, improved SWNT dispersion, and/or longer polymer chains increase the elastic response of the nanocomposite, as is consistent with our description of the nanotube network.
Carrier loss in InGaAsP-InP lasers grown by hydride CVD (1995)

We have experimentally characterized the quantum efficiency in InGaAsP hydride CVD grown lasers operating at 1.3 /spl mu/m. The observed reduction in external quantum efficiency with increasing temperature is found to be caused mostly by a reduction of the internal quantum efficiency. The experimental results are well explained with a theoretical model based on thermionic emission of carriers out of the active region. The model also helps to understand the difference in temperature performance between lasers studied in this paper and those grown by MOCVD.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3D Analysis of Fuel Cell Electrocatalyst Degradation on Alternate Carbon Supports (2017)

Understanding the mechanisms associated with Pt/C electrocatalyst degradation in proton exchange membrane fuel cell (PEMFC) cathodes is critical for the future development of higher-performing materials; however, there is a lack of information regarding Pt coarsening under PEMFC operating conditions within the cathode catalyst layer. We report a direct and quantitative 3D study of Pt dispersions on carbon supports (high surface area carbon (HSAC), Vulcan XC-72, and graphitized carbon) with varied surface areas, graphitic character, and Pt loadings ranging from 5 to 40 wt %. This is accomplished both before and after catalyst-cycling accelerated stress tests (ASTs) through observations of the cathode catalyst layer of membrane electrode assemblies. Electron tomography results show Pt nanoparticle agglomeration occurs predominantly at junctions and edges of aggregated graphitized carbon particles, leading to poor Pt dispersion in the as-prepared catalysts and increased coalescence during ASTs. Tomographic reconstructions of Pt/HSAC show much better initial Pt dispersions, less agglomeration, and less coarsening during ASTs in the cathode. However, a large loss of the electrochemically active surface area (ECSA) is still observed and is attributed to accelerated Pt dissolution and nanoparticle coalescence. Furthermore, a strong correlation between Pt particle/agglomerate size and measured ECSA is established and is proposed as a more useful metric than average crystallite size in predicting degradation behavior across different catalyst systems.
Low-Loss Impedance-Matched Sub-25-μm Vias in 3-D Millimeter-Wave Packages (2020)

This article presents, for the first time, low-loss small microvias in build-up layers for the next-generation highdensity high-performance fifth-generation (5G) millimeter-wave (mm-wave) antenna-integrated packages. As the operating frequency increases, the signal losses in antenna packages become more critical and need to be mitigated to obtain desired performance in beamforming and massive multi-input multioutput. As electrical wavelengths in mm-wave spectra are short, the signal losses caused by microvias dominate the loss budget. To minimize the signal losses and identify the required microvia diameter in build-up layers, this article first focuses on the modeling of small microvias for impedance matching. Based on the models and simulated characteristic impedance, test vehicles with daisy chains are fabricated in build-up layers on a core package substrate. Ultraviolet (UV) laser is utilized to drill microvias, and targeted microvia diameters are obtained through a semiadditive patterning process. High-frequency measurements are also performed to correlate with the models and simulated results in the 28-GHz band. The characterization results exhibit good model-to-hardware correlation and indicate that small microvias (20 μm) provide impedance closer to 50 Ω compared with the larger microvias. This matched microvia impedance lowers reflection and insertion loss, resulting in a 10% reduction in the signal losses caused by microvias in the 5G New-Radio n257 band around 28 GHz.
Convertisseur millimétrique optique à bande latérale unique pour le transport radio sur fibre (1999)

Une source optique a bande laterale unique a ete developpee et fabriquee afin de pouvoir propager un signal radio-millimetrique sur une fibre optique standard a 1. 55 m sans subir de penalite du a la dispersion chromatique. Cette source integre monolithiquement un laser dfb, deux modulateurs electro-absorbants large bande 40 ghz, un amplificateur a semi-conducteurs et des coupleurs passifs de type mmi. La partie active est realisee en structure unique et la reprise passive en cbe. Une etude theorique approfondie permet de cerner l'ensemble des parametres de la source afin, en particulier, de connaitre les tolerances de fabrication du composant. Les mesures montrent que le signal radio (38 ghz) peut se propager sur plus de 50 km sans evanouissement, avec seulement une fluctuation de puissance residuelle de moins de 2 db. Le taux de rejection des bandes laterales est d'au moins 10 db. Des methodes de caracterisations precises de la source ont ete developpees. Des experiences systemes ont ete faites avec transmission de trames mpeg-2 sur differents formats de modulation : dqpsk et m-qam. Ils montrent le tres bon comportement de la source, specialement en linearite, par des constellations serrees et des taux d'erreurs proches de la theorie (1db de penalite en 64-qam).
Comparison of Fc-fragment and IL-7-Fc on accumulation of T cells in cervicovaginal tissue from Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells (2023)

&lt;p&gt;Supplementary Figure 4. Comparison of Fc-fragment and IL-7-Fc on accumulation of T cells in cervicovaginal tissue&lt;/p&gt;