gebhart/patrepeval huggingface dataset:
Stability of learning control with disturbances and uncertain initial conditions (1992)

The authors investigate the effects of state disturbances, output noise, and errors in initial conditions on a class of learning control algorithms. They present a simple learning algorithm and exhibit, via a concise proof, bounds on the asymptotic trajectory errors for the learned input and the corresponding state and output trajectories. Furthermore, these bounds are continuous functions of the bounds on the initial condition errors, state disturbances, and output noise, and the bounds are zero in the absence of these disturbances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds (2014)

A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitans to These Antibiotics (2000)

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.
Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney (2003)

Recent studies have indicated that urotensin II (UII), a cyclic peptide, is vasoactive and may be involved in cardiovascular dysfunctions. It remains unknown, however, whether UII plays a role in the control of renal vascular tone and tubular function. In the present study, a continuous infusion of synthetic human UII (hUII) into the renal artery (RA) in anesthetized rats was found to increase renal blood flow (RBF) and urinary water and sodium excretion (UV and UNaV) in a dose-dependent manner. At a dose of 20 ng. kg-1. min-1, it increased RBF by 20% and UV and UNaV by 94 and 109%, respectively. Nitric oxide (NO) synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME) completely abolished hUII-induced increases in RBF and water/sodium excretion. In isolated, pressurized, and phenylephrine-precontracted small RA with internal diameter of approximately 200 microm, hUII produced a concentration-dependent vasodilation with a maximal response of 55% at 1.5 microM. l-NAME significantly blocked this hUII-induced vasodilation by 60%. In denuded RA, hUII had neither vasodilator nor vasoconstrictor effect. With the use of 4,5-diaminofluorescein diacetate-based fluorescence imaging analysis of NO levels, hUII (1 microM) was shown to double the NO levels within the endothelium of freshly dissected small RA, and l-NAME blocked this UII-induced production of endothelial NO. These results indicate that UII produces vasodilator and natriuretic effects in the kidney and that UII-induced vasodilation is associated with increased endothelial NO in the RA.
On the design of large degree-of-freedom digital mechatronic devices based on bistable dielectric elastomer actuators (2006)

Binary actuation has been proposed to reduce complexity in robotic and mechatronic systems. However, a relatively large number of binary actuators are required to achieve the accuracy necessary for practical applications. Conventional actuators are not practical for such large degree-of-freedom (DoF) devices. Here, a dielectric elastomer (DE) actuator is developed for these applications. It is shown that DE actuators have high energy densities, light weight, low cost, and large displacements. Hence they could potentially make large DoF binary systems practical. DE actuators proposed here consist of thin electrically sensitive elastomer films that are mounted in a flexible frame that incorporates a passive bistable element. The frame prestrains the film and provides a restoring force that allows the actuator to operate bidirectionally. A simple experimental prototype 6-DoF binary manipulator demonstrates the concept
?Happy Days are Here Again?: Cocoa Farmers, Middlemen Traders and the Structural Adjustment Program in Southwestern Nigeria, 1986-1990s (2000)

Ezekiel Ayodele Walker, "Happy Days Are Here Again": Cocoa Farmers, Middlemen Traders and the Structural Adjustment Program in Southwestern Nigeria, 1986-1990s, Africa Today, Vol. 47, No. 2 (Spring, 2000), pp. 151-169
Identification of Proliferation-Induced Genes in Arabidopsis thaliana (Characterization of a New Member of the Highly Evolutionarily Conserved Histone H2A.F/Z Variant Subfamily) (1997)

The changes in gene expression associated with the reinitiation of cell division and subsequent progression through the cell cycle in Arabidopsis thaliana cell-suspension cultures were investigated. Partial synchronization of cells was achieved by a technique combining phosphate starvation and a transient treatment with the DNA replication inhibitor aphidicolin. Six cDNAs corresponding to genes highly induced in proliferating cells and showing cell-cycle-regulated expression were obtained by the mRNA differential display technique. Full-length cDNA clones (cH2BAt and cH2AvAt) corresponding to two of the display products were subsequently isolated. The cH2BAt clone codes for a novel histone H2B protein, whereas the cH2AvAt cDNA corresponds to a gene encoding a new member of the highly conserved histone H2A.F/Z subfamily of chromosomal proteins. Further studies indicated that H2AvAt mRNA expression is tightly correlated with cell proliferation in cell-suspension cultures, and that closely related analogs of the encoded protein exist in Arabidopsis. The implications of the conservation of histone H2A.F/Z variants in plants are discussed.
Spectral Methods in the Statistical Description and Design of Microstructure (2008)

This chapter contains sections titled: Homogenization Relations Introduction The Weak and Strong Contrast Formulations Results and Discussion Phase Recovery Reconstruction Algorithm Introduction Phase Recovery Algorithm Results and Discussion Conclusions Acknowledgements References
How we do it: Clinical management of the child receiving a second, bilateral cochlear implant (2009)

For children to gain maximum benefit from a second, bilateral cochlear implant clinicians need to be aware of the special needs of the family and child, and to adapt their clinical management appropriately. This article describes how the situation of the family considering a second implant is different, and how the decision to be made differs from that for a first implant. The information specific to sequential implants that should be provided so families can make an informed decision is reviewed. Programming issues unique to sequential bilateral cochlear implants are discussed. Finally, information is provided on how children may respond post-operatively, and what can be done to promote bilateral device use and the development of listening skills with the new implant.
TSP Tours in Cubic Graphs: Beyond 4/3 (2015)

After a sequence of improvements Boyd et al. [TSP on cubic and subcubic graphs, Integer Programming and Combinatorial Optimization, Lecture Notes in Comput. Sci. 6655, Springer, Heidelberg, 2011, pp. 65--77] proved that any 2-connected graph whose $n$ vertices have degree 3, i.e., a cubic 2-connected graph, has a Hamiltonian tour of length at most (4/3)n, establishing in particular that the integrality gap of the subtour LP is at most 4/3 for cubic 2-connected graphs and matching the conjectured value of the famous 4/3 conjecture. In this paper we improve upon this result by designing an algorithm that finds a tour of length (4/3-1/61236)n, implying that cubic 2-connected graphs are among the few interesting classes of graphs for which the integrality gap of the subtour LP is strictly less than 4/3. With the previous result, and by considering an even smaller $\epsilon$, we show that the integrality gap of the TSP relaxation is at most $4/3- \epsilon$ even if the graph is not 2-connected (i.e., for cubic connected graphs), implying that the approximability threshold of the TSP in cubic graphs is strictly below 4/3. Finally, using similar techniques we show, as an additional result, that every Barnette graph admits a tour of length at most (4/3 - 1/18)n.
An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces sterile immunity and prevents transmission of SARS-CoV-2 between cats (2021)

Abstract Early in the global SARS-CoV-2 pandemic concerns were raised regarding infection of other animal hosts and whether these could play a significant role in the viral epidemiology. Infection of animals could be detrimental by causing clinical disease but also of concern if they become a viral reservoir allowing further mutations, plus having the potential to infect other animals or humans. The first reported animals to be infected both under experimental conditions and from anecdotal field evidence were cats described in China early in 2020. Given the concerns this finding raised and the close contacts between humans and cats, we aimed to determine whether a vaccine candidate could be developed that was suitable for use in multiple susceptible animal species and whether this vaccine could reduce infection of cats in addition to preventing spread to other cats. Here we report that a Replicon Particle (RP) vaccine based on Venezuelan equine encephalitis virus (VEEV), known to be safe and efficacious for use in a variety of animals, expressing a stabilised Spike antigen, could induce neutralising antibody titers in guinea pigs and cats. After two intramuscular vaccinations, virus neutralising antibodies were detected in the respiratory tract of the guinea pigs and a cell mediated immune response was induced. The design of the SARS-CoV-2 antigen was shown to be critical in developing a strong neutralising antibody response. Vaccination of cats was able to induce a serum neutralising antibody response which lasted for the course of the experiment. Interestingly, in contrast to control animals, infectious virus could not be detected in oropharyngeal or nasal swabs of vaccinated cats after challenge. Moreover, the challenged control cats spread the virus to in-contact cats whereas the vaccinated cats did not transmit virus. The results show that the RP vaccine induces sterile immunity preventing SARS-CoV-2 infection and transmission. This data suggests that this RP vaccine could be a multi-species vaccine useful for preventing spread to and between other animals should that approach be required.
New Trends towards Well‐Defined Low‐Valent Iron Catalysts (2011)

Less is more: This Highlight describes a simple new procedure to access well-defined formal low-valent iron complexes by ligand exchange and reductive elimination (see scheme). This method offers a good starting point for the further development of iron catalysts.
Aortic root geometry: pattern of differences between leaflets and sinuses of Valsalva. (1999)

The data showed a geometric pattern of the aortic root, with the structures of the non-coronary sinus being the largest followed by the right and then the left. The possible hemodynamic relevance and surgical implications of these findings need to be explored.
Chloro(dimethylamido) compounds of tantalum(V): Preparations, properties, and structures of [Ta(NMe2)3Cl2]2, TaCl3(NMe2)2(HNMe2), Ta(NMe2)3Cl2(HNMe2), and [TaCl2(NMe2)2(HNMe2)]2O (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChloro(dimethylamido) compounds of tantalum(V): Preparations, properties, and structures of [Ta(NMe2)3Cl2]2, TaCl3(NMe2)2(HNMe2), Ta(NMe2)3Cl2(HNMe2), and [TaCl2(NMe2)2(HNMe2)]2OMalcolm H. Chisholm, John C. Huffman, and Loon-Seng. TanCite this: Inorg. Chem. 1981, 20, 6, 1859–1866Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://pubs.acs.org/doi/10.1021/ic50220a049https://doi.org/10.1021/ic50220a049research-articleACS PublicationsRequest reuse permissionsArticle Views494Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Structure-Based Stabilization of Non-native Protein–Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design (2020)

Structure-based stabilization of protein-protein interactions (PPIs) is a promising strategy for drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Here, we identified a non-native interaction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed that 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell. This unique approach based on the identification and stabilization of non-native PPIs of N protein could be applied toward drug discovery against CoV diseases.
BCDL: a high speed balanced DPL for FPGA with global precharge and no early evaluation (2010)

In this paper, we present BCDL (Balanced Cell-based Dual-rail Logic), a new counter-measure against Side Channel Attacks (SCA) on cryptoprocessors implementing symmetrical algorithms on FPGA. BCDL is a DPL (Dual-rail Precharge Logic), which aims at overcoming most of the usual vulnerabilities of such counter-measures, by using specific synchronization schemes, while maintaining a reasonable complexity. We compare our architecture in terms of complexity, performances and easiness to design with other DPLs (WDDL, IWDDL, MDPL, iMDPL, STTL, DRSL, SecLib). It is shown that BCDL can be optimized to achieve higher performances than any other DPLs (more than 1/2 times the nominal data rate) with an affordable complexity. Finally, we implement a BCDL AES on an FPGA and compare its robustness against DPA by using the number of Measurements To Disclosure (MTD) required to find the key with regards to unprotected AES. It is observed that the SCA on a BCDL implementation failed for 150,000 power consumption traces which represents a gain greater than 20 w.r.t. the unprotected version. Moreover the fault attack study has pointed out the natural resistance of BCDL against simple faults attacks.
Methodology for the Quantitative Evaluation of the Remaining Fatigue Life of Fracture Critical Bridges (2007)

Two fracture critical bridges were instrumented using miniature, battery-powered data acquisition systems as part of this investigation. The measured rainflow response was then used to estimate the remaining fatigue life of each bridge. The primary advantages of the monitoring system are that the units were designed to be installed easily in the field and interpretation of the rainflow data is straightforward. However, to utilize the full potential of the monitoring system, analytical models of each bridge must be developed prior to instrumentation and careful evaluation of the rainflow data is required. Incorporating the data acquisition units into regular inspections of fracture critical bridges will represent a significant change in TxDOT procedures. However, the rainflow data provide a quantitative metric for identifying the bridges that are most vulnerable to fatigue damage and will assist TxDOT in setting priorities for inspection and replacement of these bridges as they approach the end of their service life.
Saturation Characteristics Simulation of Intersubband Absorption for [(CdS/ZnSe/BeTe)/(ZnSe/BeTe)] Coupled Quantum Wells (2008)

The saturation characteristics of II–VI coupled quantum wells (CQWs) were simulated by solving the polarization equation and rate equations. By considering different operation frequency requirements, the dependence of the switching energy (Es) on the ZnSe well thickness was investigated for different pump pulse widths. Each pulse width corresponds to an optimum ZnSe well thickness at which Es reaches its minimum due to the agreement between the pulse width and the effective relaxation time.
Transient Cardiac Rhythm Changes (2021)

Scenario: The 2 rhythm strips shown here (approximately 18 minutes apart) are from a 76-year-old woman admitted to the cardiac telemetry unit for exacerbation of heart failure. The patient’s history includes hypertension, type 2 diabetes, diastolic heart failure due to long-standing hypertension, and an atrioventricular (AV) pacemaker. The patient is resting comfortably in bed and is scheduled for discharge in the late afternoon. Given the rhythm strips, is it safe to discharge the patient?Normal sinus rhythm with possible right atrial enlargement and secondary repolarization changes. There is intermittent AV paced rhythm with appropriate AV sensing and pacing.A 3-letter code is used to describe the type of pacing used. The first letter denotes the chamber paced: A = atrium, V = ventricle, D = dual (ie, both A and V). The second letter denotes the chamber sensed, using the same nomenclature. Sensing inhibits pacing when an intrinsic P wave and/or QRS complex is present. The third letter denotes the response to sensing: I = inhibit, T = triggered, and D = dual function. In the top electrocardiography (ECG) strip, atrial activity is sensed (consistent P waves); thus, atrial pacing is inhibited. However, after the seventh P wave, an intrinsic QRS complex does not occur for >22 milliseconds, which triggers ventricular pacing. In the bottom strip, just after the ventricular paced beat, a P wave is not sensed and atrial pacing occurs. However, an intrinsic QRS complex occurs after atrial pacing, thus inhibiting ventricular pacing. By the sixth beat, both P waves and QRS complexes are sensed, thus inhibiting both atrial and ventricular pacing. This pattern suggests that the patient’s pacemaker is DDD. Moreover, the asymmetric biphasic P waves suggest atrial enlargement. Given that the impulse propagates from right to left atrium, a larger initial P compared with the terminal P’ suggests that the right chamber is the one enlarged. The T-wave inversion in lead II is most likely secondary repolarization changes due to diastolic dysfunction and right ventricular hypertrophy (cor pulmonale), consistent with the patient’s history. Verify with a 12-lead ECG and/or echocardiogram if available.The development of the first-degree AV block is the reason that transient pacing occurs. Medications (ie, β-blockers and/or digoxin) are a potential source of the problem, so medications in use should be evaluated as a possible cause and adjusted accordingly. Digoxin blood levels would be helpful; however, this patient is not taking digoxin. This patient’s DDD pacer is functioning properly; hence, no intervention is necessary and the patient can be discharged home.
Estimating a Conditional Expectation with the Generalized Likelihood Ratio Method (2021)

In this paper, we consider the problem of efficiently estimating a conditional expectation. By formulating the conditional expectation as a ratio of two derivatives, we can apply the generalized likelihood ratio method to express the conditional expectation using ordinary expectations with indicator functions, which generalizes the conditional density method. Based on an empirical distribution estimated from simulation, we provide guidance on selecting the appropriate formulation of the derivatives to reduce the variance of the estimator.
JFC1, a Novel Tandem C2 Domain-containing Protein Associated with the Leukocyte NADPH Oxidase (2001)

We have employed a yeast two-hybrid system to screen a B lymphoblast-derived cDNA library, searching for regulatory components of the NADPH oxidase. Using as bait the C-terminal half of p67(phox), which contains both Src homology 3 domains, we have cloned JFC1, a novel human 62-kDa protein. JFC1 possesses two C2 domains in tandem. The C2A domain shows homology with the C2B domain of synaptotagmins. JFC1 mRNA was abundantly expressed in bone marrow and leukocytes. The expression of JFC1 in neutrophils was restricted to the plasma membrane/secretory vesicle fraction. We confirmed JFC1-p67(phox) association by affinity chromatography. JFC1-containing beads pulled down both p67(phox) and p47(phox) subunits from neutrophil cytosol, but when the recombinant proteins were used, only p67(phox) bound to JFC1, indicating that JFC1 binds to the cytosolic complex via p67(phox) without affecting the interaction between p67(phox) and p47(phox). In contrast to synaptotagmins, JFC1 was unable to bind to inositol 1,3,4,5-tetrakisphosphate but did bind to phosphatidylinositol 3,4,5-trisphosphate and to a lesser extent to phosphatidylinositol 3,4-diphosphate. From the data presented here, it is proposed that JFC1 is acting as an adaptor protein between phosphatidylinositol 3-kinase products and the oxidase cytosolic complex.