gebhart/patrepeval huggingface dataset:
An evaluation of four light-curing units comparing soft and hard curing. (1999)

Composite resin shrinks during polymerization producing marginal gaps around composite restorations. While incremental placement of composite resin has been used to control shrinkage, this technique is time consuming. Curing lights have been developed with varying outputs and curing cycles to speed curing and reduce marginal gaps in composite restorations. This investigation measured the marginal openings of Class V resin restorations cured with four different light-curing units. High-intensity curing units provided rapid curing to composite resin increments, but the two-phase curing cycle afforded significantly better marginal integrity than the other units.
Overview of recurrent respiratory papillomatosis (2003)

Pediatric RRP continues to be a highly morbid disease process. New surgical and medical therapies offer hope for better control of this disease in affected patients. Recent advances in immunologic research offer the hope of immune system modulation and augmentation as potential future treatment modalities to better control this disease process.
Efficient Tunable Solid State Laser Around 630 Nm Using Sulforhodamine 640 Doped Silica Gel (1989)

Laser effect around 630 nm is observed in a sulforhodamine 640 doped iiica gel pumped by a Q switch doubled Nd:YAG laser. A conversion efficiency of 20 % is obtained. The laser wavelength can be tuned over 40 nm.
Laboratory Measures of Postural Control During the Star Excursion Balance Test After Acute First-Time Lateral Ankle Sprain (2015)

Acute first-time LAS was associated with bilateral deficits in postural control, as evidenced by the bilateral reduction in angular displacement of the lower extremity joints and reduced reach distances and FD of the COP path on the injured limb during performance of the SEBT.
Alcohol Rapidly Lowers Plasma Testosterone Levels in the Rat: Evidence that a Neural Brain‐Gonadal Pathway May Be Important for Decreased Testicular Responsiveness to Gonadotropin (1999)

Alcohol is reported to suppress testosterone (T) secretion in the adult male rat. Decreases in the circulating levels of luteinizing hormone (LH) and/or the activity of testicular steroidogenic enzymes have been proposed as putative mechanisms underlying this inhibitory effect. We have recently provided functional evidence for a neural pathway between the brain and the male gonads that plays an important role in the ability of brain proinflammatory cytokines to blunt testicular responsiveness to human chorionic gonadotropin (hCG). The present work was designed to test the hypothesis that a similar pathway might be implicated in the inhibitory influence of alcohol on T secretion. Alcohol, administered intraperitoneally or intragastrically, significantly prevented the T response to the gonadotropin. This effect was significant within 15 min of drug treatment. In the intragastric model (the only one used for this type of experiment), the effect of alcohol was not altered by prior blockade of LH release, which suggests that it is independent of changes in the activity of the pituitary gonadotrophs. The lowest effective dose of alcohol, delivered intraperitoneally, was 2.0 g/kg. The intracerebroventricular injection of the alpha- and beta-adrenergic receptor antagonists phentolamine and propranolol significantly reversed the inhibitory influence of alcohol when it was administered 15 min, but not 60 min, before hCG. Collectively, our results indicate that (1) alcohol induces a rapid and profound decrease in plasma T levels that is secondary to decreased testicular responsiveness to hCG; and (2) at least part of this acute inhibitory action of alcohol may depend on the activation of a neural, adrenergic-dependent pathway between the brain and the testes.
Toward the Characterization of Human Pro-Resolving Macrophages? (2020)

International audience
Blood Ammonia Levels after Intravenous Infusion of Glycine Solution with and without Ethanol (1999)

Ethanol 1% did not reduce the increase in blood ammonia concentration after the administration of glycine solution.
Glass, 1. Fundamentals (2011)

Abstract The article contains sections titled: 1. Definition and Historical Summary 2. Structure of Glass 2.1. Structure of Special Melts and Glasses 2.2. Composition of Glass 2.2.1. Single‐Component Glass 2.2.2. Silicate Glasses with Two Components 2.2.3. Borate, Phosphate, and Germanate Glasses 2.2.4. Borosilicate and Aluminosilicate Glasses 2.2.5. Lead Silicate Glasses 2.2.6. Chalcogenide Glasses 2.2.7. Halide Glasses 2.2.8. Glasses with Complex Composition 3. Glass Formation, Crystallization, and Liquid Immiscibility 4. Chemical, Mechanical, and Physical Properties of Industrially Important Melts and Glasses 4.1. Rheological Properties of Glass Melts 4.1.1. Temperature Dependence of Viscosity 4.1.2. Time Dependence of Viscosity 4.1.3. Composition Dependence of Viscosity 4.2. Surface Tension 4.3. Density 4.4. Thermal Expansion 4.5. Elastic Properties 4.6. Mechanical Strength 4.7. Hardness 4.8. Viscoelastic Properties 4.9. Thermal Properties 4.10. Electrical Properties 4.11. Gas Permeability 4.12. Chemical Stability and Surface Properties 4.13. Optical Properties 4.13.1. Transmission, Absorption, and Reflection 4.13.2. Refractive Index, Dispersion, and Optical State 4.13.3. Temperature Dependence of Refractive Index 4.13.4. Stress Optical Coefficients 4.13.5. Radiation Effects 4.14. Color of Glasses
Molecular Diagnosis of Human Papillomavirus: Comparison Between Cervical and Vaginal Sampling (2001)

Correlation between vaginal and endocervical sampling methods was excellent in detecting the presence of HPV DNA and for identifying distinct HPV genotypes. Utilization of vaginal testing for routine HPV detection, and for the long-term follow-up of persistent HPV infection, is therefore recommended.
Back to the future Climate Change and the Health of Nations Famines, Fevers, and the Fate of Populations Anthony J. McMichael Oxford University Press, 2017. 390 pp. (2017)

An epidemiologist takes a long view of our fraught relationship with the environment
Synthesis of a Chiral Helical Molecular Template Based on trans-5,6,6a,7,8,12b-Hexahydro-1,12-dimethylbenzo[c]phenanthrene- 5,8-dione (1997)

Reduction of trans-5,5,6a,7,8,12b-hexahydro-1,12-dimethylbenzo[c]phenanthrene-5,8-dione (1, R(1) = R(4) = H, R(2) = R(3) = CH(3)) with lithium aluminum hydride yielded stereoselectively (5RS,8RS)-trans-5,6,6a,7,8,12b-hexahydro-1,12-dimethylbenzo[c]phenanthrene-5,8-diols 2, X = H. These diols proved to be configurationally stable chiral molecular templates capable of straightforward modification by attachment of molecular elements of different length and kind. The structures of the diacetate 2, X = COCH(3), and (5R,8R)-(-)-trans-5,6,6a,7,8,12b-hexahydro-1,12-dimethylbenzo[c]phenanthrene-5,8-diyl di-p-bromobenzoate (2a, X = p-BrC(6)H(4)CO), as well as the absolute configuration of the latter were obtained by X-ray crystallography.
A new mutation in the TYMP-gene: clinical and morphological characteristics of a patient with MNGIE syndrome (2022)

Mitochondrial neurogastrointestinal encephalomyopathy is an extremely rare (1–9:1 000 000, Orphanet, 2021) multisystem genetic disease caused by mutations in the TYMP gene encoding the enzyme thymidine phosphorylase.The article presents the data of a thirteen‑year survey on 40‑year‑old patient D. with clinical manifestations of mitochondrial neurogastrointestinal encephalomyopathy syndrome associated with the previously undescribed missense mutation c.1301GT (p.Gly434Val) of the TYMP gene. Detailed clinical picture (gastrointestinal dysfunction, cachexia, blepharoptosis, ophthalmoparesis, peripheral polyneuropathy and leukoaraiosis), electroneuromyography data (demyelination with secondary axonopathy), high blood serum level of dihydrothymine together with normal levels of thymidine and deoxyuridine made it possible to verify the diagnosis. Histopathological examination revealed atrophy of the longitudinal (outer) muscle layer of the small and large intestines and a significant decrease in the number of CD117+ cells (telocytes), signs of damage to the striated skeletal muscles of a mixed nature with a predominance of the myogenic pattern, as well the destruction of the myelin sheaths of peripheral nerves. Histochemical examination did not reveal “ragged red fibers” characteristic of mitochondrial pathology. Transmission electron microscopy demonstrated the presence of megalomitochondria in the myocardium.
Inactivated Sendai virus particle upregulates cancer cell expression of intercellular adhesion molecule‐1 and enhances natural killer cell sensitivity on cancer cells (2017)

We have already reported that the inactivated Sendai virus (hemagglutinating virus of Japan; HVJ) envelope (HVJ-E) has multiple anticancer effects, including induction of cancer-selective cell death and activation of anticancer immunity. The HVJ-E stimulates dendritic cells to produce cytokines and chemokines such as β-interferon, interleukin-6, chemokine (C-C motif) ligand 5, and chemokine (C-X-C motif) ligand 10, which activate both CD8<sup>+</sup> T cells and natural killer (NK) cells and recruit them to the tumor microenvironment. However, the effect of HVJ-E on modulating the sensitivity of cancer cells to immune cell attack has yet to be investigated. In this study, we found that HVJ-E induced the production of intercellular adhesion molecule-1 (ICAM-1, CD54), a ligand of lymphocyte function-associated antigen 1, in several cancer cell lines through the activation of nuclear factor-κB downstream of retinoic acid-inducible gene I and the mitochondrial antiviral signaling pathway. The upregulation of ICAM-1 on the surface of cancer cells increased the sensitivity of cancer cells to NK cells. Knocking out expression of ICAM-1 in MDA-MB-231 cells using the CRISPR/Cas9 method significantly reduced the killing effect of NK cells on ICAM-1-depleted MDA-MB-231 cells. In addition, HVJ-E suppressed tumor growth in MDA-MB-231 tumor-bearing SCID mice, and the HVJ-E antitumor effect was impaired when NK cells were depleted by treatment with the anti-asialo GM1 antibody. Our findings suggest that HVJ-E enhances NK cell sensitivity against cancer cells by increasing ICAM-1 expression on the cancer cell surface.
Diagnostic Accuracy and Reading Time to Detect Intracranial Aneurysms on MR Angiography Using a Computer-Aided Diagnosis System (2008)

The use of a CAD system for the detection of intracranial aneurysms on MR angiography can shorten the reading time while improving diagnostic performance for less experienced radiologists.
Walking Quality During Inpatient Stroke Rehabilitation Assessed by Wireless Sensing (P5.176) (2015)

OBJECTIVE: Demonstrate that the quality of gait, in addition to walking speed and distance, can be derived from inertial sensors worn at both ankles. BACKGROUND: The international Stroke Inpatient Rehabilitation Reinforcement of ACTivity (SIRRACT) trial deployed wireless sensors and activity-recognition algorithms to monitor and provide feedback about the quantity of stroke patients’ daily walking activity (epub, Neurorehabil Neural Repair, 2014). This follow-up study aimed to characterize the quality of walking by calculating spatiotemporal gait metrics. DESIGN/METHODS: In SIRRACT, 135 trial participants wore sensors throughout the average 3-week inpatient rehabilitation admission. Stopwatch-timed 10-meter walks (performed weekly for system calibration) were selected for the current analysis. Individual steps were delimited by identifying heel strike and toe-off times. Metrics including gait cycle duration, symmetry of stance and swing times, and double-limb support time were calculated for both the paretic and non-paretic limbs. The magnitude of peak lower leg acceleration during the swing phase of gait was also calculated. RESULTS: Data from five trial participants are presented as exemplars. Walking speeds averaged 0.24 ± 0.14m/s on study entry and 0.81 ± 0.35m/s at the time of discharge. Gait cycle duration decreased during rehabilitation (median:334ms [211,853]), as did double-limb support time (median:188ms [72,681]). Stance and swing time asymmetries were present throughout rehabilitation. Peak swing-time acceleration of the paretic leg was greater at discharge (median:0.20g-units [0.15,0.31]). CONCLUSIONS: The laboratory-quality gait metrics calculated by our wireless sensor system were sensitive to functional improvements during a period of known clinical recovery. Commercial sensor systems, for which steps counts are inaccurate at the slow speeds typical of hemi-paretic walking, have difficulty producing outcomes related to motor control in persons disabled by neurologic disease. Measurement of the quantity and quality of movements performed during daily activities enables clinicians and researchers to supervise gait training and skills practice during rehabilitation.
Hollow Mesoporous Carbon Nanospheres Decorated with Metal Oxide Nanoparticles as Efficient Earth‐Abundant Zinc‐Air Battery Catalysts (2021)

Abstract Hybrids comprising hollow mesoporous nitrogen‐doped carbon (HMC) nanospheres and metal‐oxide nanoparticles were prepared through a hydrothermal synthesis. These materials exhibit excellent bifunctional catalytic activity in the oxygen reduction and evolution reactions (ORR and OER, respectively) that are core to the efficient operation of Zn‐air batteries. When incorporated into prototype devices, Co 3 O 4 and MnCo 2 O 4 nanoparticle‐decorated HMC exhibited discharge potentials of 1.26 and 1.28 V at 10 mA cm −2 , respectively. ‘CoFeNiO’‐decorated HMC exhibited a charging potential of 1.96 V at 10 mA cm −2 . These metrics are far superior to benchmark Pt−Ru, which displayed discharge and charging potentials of 1.25 and 2.01 V, respectively, at the same current density. The battery equipped with Co 3 O 4 ‐decorated HMC demonstrated 63 % initial efficiency before cycling. After cycling at 10 mA cm −2 for 100 hours, the battery efficiency was maintained at 56.5 %, outperforming the battery with Pt−Ru (50.2 % after 50 h).
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy (2019)

Particle tracking on a video sequence and the posterior analysis of their trajectories is nowadays a common operation in many biological studies. Using the analysis of cell membrane receptor clusters as a model, we present a detailed protocol for this image analysis task using Fiji (ImageJ) and Matlab routines to: 1) define regions of interest and design masks adapted to these regions; 2) track the particles in fluorescence microscopy videos; 3) analyze the diffusion and intensity characteristics of selected tracks. The quantitative analysis of the diffusion coefficients, types of motion, and cluster size obtained by fluorescence microscopy and image processing provides a valuable tool to objectively determine particle dynamics and the consequences of modifying environmental conditions. In this article we present detailed protocols for the analysis of these features. The method described here not only allows single-molecule tracking detection, but also automates the estimation of lateral diffusion parameters at the cell membrane, classifies the type of trajectory and allows complete analysis thus overcoming the difficulties in quantifying spot size over its entire trajectory at the cell membrane.
ECG-Based User Authentication and Identification Method on VANETs (2018)

Industry and academia continuously look for improvements in data security and privacy due to the increasing amount of pervasive applications launched every day. This paper investigates the use of electrocardiogram (ECG) as an authentication factor in VANETs and shared car context. Other authentication approaches exist, but many of them do not apply continuous authentication, resulting in scenarios where illegitimate drivers can use the vehicle as it is unlocked and on. ECG has historically been employed for healthcare monitoring and, only recently, as a biometric based on the QRS graphical deflections. We exploit the ECG biometric aspect and we employ a fiducial point detection algorithm based on Hill Climbing to detect the QRS complex. Our approach is feasible given the small time window required for data collection and the simple QRS detection process, which can be implemented in any device, different from other complex proposals.
Thermoelectric properties of hot-pressed YbAl/sub 3/ compound over temperature range 150-800 K (2002)

Small crystals of YbAl/sub 3/ have been obtained using the Bridgman or a direct synthesis method and subsequently disc-shaped compacts prepared using a hot-pressing technique. The Seebeck coefficient, electrical resistivity, thermal diffusivity and specific heat capacity were measured over a temperature range 200-800 K. Although the thermal conductivity of YbAl/sub 3/ is much higher than that of Bi/sub 2/Te/sub 3/ based alloys, YbAl/sub 3/ possesses an electrical power factor which is more than double those of Bi/sub 2/Te/sub 3/ based alloys. The thermoelectric figure of merit at room temperature is about 1.1/spl times/10/sup -3/ K/sup -1/, which is only a third of Bi/sub 2/Te/sub 3/ based thermoelectric materials. However, YbAl/sub 3/ may be a useful material for electrical power generation using waste heat with its substantially large electrical power factor providing a large electrical power density.
Direction of arrival estimation in MIMO radar systems with nonlinear reflectors (2016)

Multiple-input multiple-output (MIMO) radar systems have been shown to offer superior performance in direction of arrival (DOA) estimation applications compared to their phased array counterparts. The performance of these systems has been studied under various probing field-target interaction mechanisms. However, to the best of our knowledge, these have been restricted to linearized models. Motivated by various nonlinear imaging modalities we study DOA estimation in far field MIMO radar systems in conjunction with a power-law nonlinear probing field-target interaction mechanism and show that the nonlinearity increases the number of identifiable targets with a given number of antenna array elements.
Precursors of a Mott insulator in modulated quantum wires (1997)

We investigate the transport of interacting electrons through single-mode quantum wires whose parameters are periodically modulated on the scale of the electronic Fermi wavelength. The Umklapp scattering and backscattering of electrons can be described in terms of nonuniform quantum sine-Gordon-like models that also incorporate the effects of electronic reservoirs (electrodes) adiabatically coupled to the wire. We concentrate on weak Umklapp scattering and analyze the precursors of the Mott transition. At half-filling the temperature dependence of the extra resistance $\ensuremath{\Delta}R=R\ensuremath{-}\ensuremath{\pi}\ensuremath{\Elzxh}{/e}^{2}$ of a modulated quantum wire of length $L$ changes from the interaction-dependent ``bulk'' power-law $\ensuremath{\Delta}R\ensuremath{\propto}{T}^{{4K}_{\ensuremath{\rho}}\ensuremath{-}3}$ at high temperatures $(T\ensuremath{\gg}{v}_{\ensuremath{\rho}}/L)$ to the universal $\ensuremath{\Delta}R\ensuremath{\propto}{T}^{2}$ behavior at low temperatures $(T\ensuremath{\ll}{v}_{\ensuremath{\rho}}/L).$ Away from half-filling the ``bulk'' results are qualitatively incorrect even at high temperatures ${v}_{\ensuremath{\rho}}/L\ensuremath{\ll}T\ensuremath{\ll}{T}^{*}$ despite the fact that the electron coherence in the wire is absent in this regime.
Piezoelectric Micromachined Ultrasound Transducer (PMUT) Arrays for Integrated Sensing, Actuation and Imaging (2015)

Many applications of ultrasound for sensing, actuation and imaging require miniaturized and low power transducers and transducer arrays integrated with electronic systems. Piezoelectric micromachined ultrasound transducers (PMUTs), diaphragm-like thin film flexural transducers typically formed on silicon substrates, are a potential solution for integrated transducer arrays. This paper presents an overview of the current development status of PMUTs and a discussion of their suitability for miniaturized and integrated devices. The thin film piezoelectric materials required to functionalize these devices are discussed, followed by the microfabrication techniques used to create PMUT elements and the constraints the fabrication imposes on device design. Approaches for electrical interconnection and integration with on-chip electronics are discussed. Electrical and acoustic measurements from fabricated PMUT arrays with up to 320 diaphragm elements are presented. The PMUTs are shown to be broadband devices with an operating frequency which is tunable by tailoring the lateral dimensions of the flexural membrane or the thicknesses of the constituent layers. Finally, the outlook for future development of PMUT technology and the potential applications made feasible by integrated PMUT devices are discussed.
Incidence, patterns of progression, and outcomes of preexisting and newly discovered brain metastases during treatment with anti–PD‐1 in patients with metastatic melanoma (2019)

Anti-PD-1 therapy may change the natural history of patients with preexisting MBM. However, CNS failure during treatment with anti-PD-1 is predictive of a worse prognosis compared with extracranial progression. The results of the current study support the activity of anti-PD-1 in patients with MBM, although routine CNS imaging during therapy is warranted.
A New Facile Synthesis of 2-Substituted 4,6-Diphenyl-1,3,5-triazines (1993)

S.33-34
EUV multilayer defect compensation (MDC) by absorber patternmodification: improved performance with deposited material andother progresses (2012)

According to the ITRS, mask defects are among the top technical challenges facing the introduction of extreme ultraviolet (EUV) lithography into production. Making a defect-free multilayer EUV mask blank is not possible today, and is unlikely to happen in the next few years. This means that EUV must work with masks having multilayer defects. The method presented here compensates effects of multilayer defects by modifying absorber patterns whose images they distort. It represents the patterns to be modified with level-set methods, providing more generality than binary pixels on a fixed grid. The level-set representation and fast model used to calculate fields at the mask have been published previously. The method has been applied with constraints to ensure that the pattern modifications are within the capability of available repair equipment, and has been shown to enlarge process windows. Although prior work focused on modifying absorber patterns, additional degrees of freedom to improve performance are available if modifications include deposition of different materials. Simulated images show potential benefits with deposited carbon. To apply the method, it is necessary to solve two sequential inverse problems. First, the defect buried in the multilayer must be modeled from available information about the top surface of the mask blank. Then the absorber modifications must be calculated from the desired image and properties of the modeled defect. Accuracy and speed of the computation meet requirements for using it to manufacture EUV masks.