gebhart/patrepeval huggingface dataset:
Abstract 2080: Novel molecularly targeted combination for renal cell carcinoma (2019)

INTRODUCTION: Despite many available treatments, >90% of metastatic renal cell carcinoma (mRCC) patients die within 5 years. Due to its modest efficacy, Sorafenib (SF) is a second line treatment for mRCC. Molecular basis for SF failure is unknown. Hymecromone (HC) is a non−toxic orally bioavailable agent used in Europe for improving liver health. We examined the molecular basis of SF failure in clinical specimens and provided mechanistic evidence for why SF+HC could be a potent therapeutic combination against mRCC.METHODS: UGT1A9 (A9) levels and SF glucuronidation were measured in kidney specimens (45 normal; 86 tumor) by qPCR and a glucuronidation assay using tumor microsomes. Response to SF+HC combination in vector-only (EV), A9-overexpressing (A9) and A9-knockdown (A9-KO) 786-0 and Caki-1 transfectants, primary RCC spheroids, and endothelial cells was examined by proliferation, apoptosis, motility and invasion assays. Target analysis was performed by immunoblot. Treatment efficacy was evaluated in Caki−1 s.c. and orthotopic xenograft models, with bioluminescence imaging.RESULTS: A9 has been shown to glucuronidate and inactivate SF. A9 levels were 8-10-fold elevated in mRCC patients’ tumors compared to non-mRCC patients and normal kidney tissues. A9 levels were an independent predictor of metastasis (P=0.022; efficacy: 73%; sensitivity: 93.8%). Tumor microsomes from mRCC patients’ glucuronidated SF 5-fold higher than from non-mRCC patients. In RCC cells, HC treatment downregulated A9 levels, A9 promoter activity and inhibited SF-glucuronidation. SF (5 µM) and HC (20-40 µg/ml) combination inhibited RCC cell and primary tumor spheroid proliferation (>90%), motility/invasion (>80%), and induced apoptosis (5-fold). While A9 transfectants were resistant to SF+HC treatment, A9-KO cells were sensitive to SF alone. Endothelial cells co-cultured with A9 transfectants were resistant to SF+HC treatment. SF+HC upregulated apoptosis effectors, but downregulated CD44, RHAMM, and phospho-Met levels in EV but not A9 transfectants. HC (100 or 200 mg/kg) and SF (30 mg/kg) oral combination abrogated Caki−1 tumor growth (>80%) without serum/tissue toxicity. HC+SF treatment decreased A9 levels, Ki67 index and microvessel density. A9-overexpressing tumors were resistant to treatment.CONCLUSION: This is the first study to demonstrate that A9 overexpression in mRCC is likely a mechanism of SF failure and A9 downregulation can re-sensitize cells. HC+SF is an orally bioavailable and non-toxic combination that may be an effective therapeutic strategy for mRCC.Citation Format: Andre R. Jordan, Jiaojiao Wang, Luis E. Lopez, Daley S. Morera, Vinata B. Lokeshwar. Novel molecularly targeted combination for renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2080.
A novel form of FGF receptor‐3 using an alternative exon in the immunoglobulin domain III (1993)

Four distinct FGF receptors were cloned and characterized and it was demonstrated that the ligand binding site of FGF receptors is confined to the extracellular immunoglobulin-like (Ig)-domain 2 and 3. The Ig-domain 3 is encoded by two separate exons: exon IIIa encodes the N-terminal half, and the C-terminal half is encoded by either exon IIIb or IIIc in FGFR1 and FGFR2, whereas FGFR4 is devoid of exon IIIb. Alternative usage of exons IIIb and IIIc determine the ligand binding specificity of the receptor. To analyze the arrangement of these exons in FGFR3 we cloned the genomic sequence between exon IIIa and IIIc of FGFR3 and identified an alternative exon, corresponding to exon IIIb of the FGFR1 and FGFR2. The sequence of this exon shows Ig-domain hallmarks, 44% identity with exon IIIb of other FGF receptors and 36% identity with exon IIIc of FGFR3. Using this exon as a probe for mouse RNA as well as PCR analysis, demonstrated that exon IIIb encodes an authentic form of FGFR3 that is expressed in mouse embryo, mouse skin and mouse epidermal keratinocytes. The results demonstrate that the presence of alternative exons for Ig-domain 3 is a general phenomena in FGFR1, 2 and 3, and represents a novel genetic mechanism for the generation of receptor diversity.
Nuclear Magnetic Double Resonance Studies by the Fourier Transform Technique (1970)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ray Freeman; Nuclear Magnetic Double Resonance Studies by the Fourier Transform Technique. J. Chem. Phys. 1 July 1970; 53 (1): 457–458. https://doi.org/10.1063/1.1673811 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Bloom Filter Performance on Graphics Engines (2011)

Bloom filters are a probabilistic technique for large-scale set membership tests. They exhibit no false negative test results but are susceptible to false positive results. They are well-suited to both large sets and large numbers of membership tests. We implement the Bloom filters present in an accelerated version of BLAST, a genome biosequence alignment application, on NVIDIA GPUs and develop an analytic performance model that helps potential users of Bloom filters to quantify the inherent tradeoffs between throughput and false positive rates.
Supraclavicular neuropathy after surgical treatment of clavicular fractures: comparison of two incisions. (2014)

Electrodiagnostic study revealed similar results in both groups. According to these results, signifiant difference in mean ASES scores of both groups was not related to sensorial injury of the supraclavicular nerve.
Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells. (1994)

The infection of human colonic epithelial cells HT-29 by human immunodeficiency virus type 1 (HIV-1) occurs independently of CD4, the main HIV-1 receptor expressed on lymphocytes and macrophages. Recent studies from our group have shown that HT-29 cells express the glycosphingolipid galactosylceramide (GalCer), a potential alternative receptor for the HIV-1 envelope glycoprotein gp120. The binding of recombinant gp120 to GalCer was blocked by monoclonal antibodies directed against the third variable region (V3) of gp120, suggesting that the V3 domain was implicated in GalCer recognition. In the present report, we show that suramin, a polysulfonyl naphtylurea known to inhibit retroviral reverse transcriptases in vitro, blocks HIV-1 infection in HT-29 cells. The effect is dose dependent, with a half-maximal inhibition (IC50) achieved for a suramin concentration of 54 micrograms/ml. Since [3H]suramin was not significantly internalized into HT-29 cells during our infection assay (i.e. 2 h), we have considered the possibility that the drug could act at an extracellular step of the HIV-1 cycle. Using a high performance thin layer chromatography binding assay, we show that suramin inhibits binding of HIV-1 gp120 to purified GalCer with an IC50 of 25 micrograms/ml. Suramin does not bind to GalCer, since preincubation of GalCer with suramin did not prevent the subsequent attachment of gp120. Using a solid-phase assay, we show that [3H]suramin specifically binds to recombinant gp120 and that this binding could be blocked by a monoclonal antibody specific for the conserved GPGRAF motif of the V3 domain of gp120. We also demonstrate that [3H]suramin binds to multibranched synthetic GPGRAF peptides that block HIV-1 infection in HT-29 cells. Binding of [3H]suramin to V3 peptides is specific and inhibited by unlabeled suramin (IC50 of 28 micrograms/ml). In contrast, the suramin derivative NF036, that is unable to block HIV-1 infection in HT-29 cells, does not inhibit the binding of [3H]suramin to V3 peptides. Taken together, these results suggest that suramin blocks HIV-1 infection in HT-29 cells because it binds to the V3 domain of gp120 and hence prevents the interaction between gp120 and the GalCer receptor.
Neural networks and response surface polynomials for design of vehicle joints (1998)

Abstract Typically, design of a complex system starts by setting targets for its performance characteristics. Then, design engineers cascade these targets to the components and design the components to meet these targets. It is important to have efficient tools that check if a set of performance targets for a component corresponds to a feasible design and determine the dimensions and mass of this design. This paper describes a method to develop tools that relate response parameters that describe the performance of a component to the physical design variables that specify its geometry. Neural networks and response surface polynomials are used to rapidly predict the performance characteristics of the components given the component dimensions. The method is demonstrated on design of an automotive joint. The paper compares neural networks and response surface polynomials and shows that they are almost equally accurate for the problem considered.
Measurement of the branching ratio for the decay η→μ+μ− (1994)

A new measurement of the branching ratio for the decay \ensuremath{\eta}\ensuremath{\rightarrow}${\mathrm{\ensuremath{\mu}}}^{+}$${\mathrm{\ensuremath{\mu}}}^{\mathrm{\ensuremath{-}}}$, made at the SATURNE II proton synchrotron, resulted in \ensuremath{\Gamma}(\ensuremath{\eta}\ensuremath{\rightarrow}${\mathrm{\ensuremath{\mu}}}^{+}$${\mathrm{\ensuremath{\mu}}}^{\mathrm{\ensuremath{-}}}$)/\ensuremath{\Gamma}(\ensuremath{\eta}\ensuremath{\rightarrow}all)= [5.7\ifmmode\pm\else\textpm\fi{}0.7(stat.)\ifmmode\pm\else\textpm\fi{}0.5(syst.)]\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}6}$. The reaction pd${\ensuremath{\rightarrow}}^{3}$He\ensuremath{\eta} close to threshold yielded 800 ${\mathrm{s}}^{\mathrm{\ensuremath{-}}1}$ tagged \ensuremath{\eta}'s in a narrow momentum band around 257 MeV/c. Muon pairs were detected in two range telescopes. The data obtained consist of 114 events \ensuremath{\eta}\ensuremath{\rightarrow}${\mathrm{\ensuremath{\mu}}}^{+}$${\mathrm{\ensuremath{\mu}}}^{\mathrm{\ensuremath{-}}}$ on a background of 14 events. The new value for the branching ratio is 1.3\ifmmode\pm\else\textpm\fi{}0.2 times the unitarity lower limit, consistent with most quark and vector meson dominance models which describe the decay as an electromagnetic transition with a two-photon intermediate state. The result resolves the discrepancy between the two previous measurements of this branching ratio.
Reliable Minimum Cycle Time of 5G NR Based on Data-Driven Channel Characterization (2021)

Wireless communication is evolving to support critical control in automation systems. The fifth-generation (5G) mobile network air interface New Radio adopts a scalable numerology and mini-slot transmission for short packets that make it potentially suitable for critical control systems. The reliable minimum cycle time is an important indicator for industrial communication techniques but has not yet been investigated within 5G. To address such a question, this article considers 5G-based industrial networks and uses the delay optimization based on data-driven channel characterization (CCDO) approach to propose a method to evaluate the reliable minimum cycle time of 5G. Numerical results in three representative industrial environments indicate that following the CCDO approach, 5G-based industrial networks can achieve, in real-world scenario, millisecond-level minimum cycle time to support several hundred nodes with reliability higher than 99.9999%.
Group Key Locking Scheme in Mobile IPv6 Networks (2007)

Mobile multicast has two points of view. One is focused on the mobile receiver and the other is focused on the mobile source. Mobile multicast also has two approaches. When a mobile source wants to send multicast traffic, it uses either a designated router in the foreign network or its home agent (HA). These are called remote approach and bi-directional tunneling approach respectively. When a mobile receiver wants to subscribe multicast traffic, it uses either remote-subscription approach or bi-directional tunneling approach also. In the meantime, there needs to be a group key management scheme to treat multicast traffic safe. It is important that group key update occurs to preserve the join/leave secrecy when group membership changed. It is also important that maintaining scalability to manage highly dynamic membership. When a mobile sender or receiver changes its attachment point, a group key update occurs extremely many times in traditional group key management schemes with remote approach. Thus, to solve this problem, we propose new group key management scheme in this paper. The proposed scheme prevents the group key update during channel migration. Hence, it can help reducing overhead which is caused by group key update, providing salability and maintaining the join/leave secrecy.
Effect of video latency on performance and subjective experience in laparoscopic surgery (2013)

Rationale Minimally invasive surgery enables surgery with minimal trauma to the patient using specialized instruments and video acquired from an optical camera (endoscope) which is visualized on a display. Latency in the imaging chain can cause dissociation between perception and action, which can degrade the surgeon’s performance. Existing latency studies focus mostly on robotic surgery, and results are inconsistent: some indicate latencies of 500 milliseconds (ms) are feasible, while others note performance degradation at 250 ms, and very few test latencies below 250 ms. In addition, task duration and errors are measured, but not the surgeon’s subjective experience. This study aims to fill the gap by studying the effects of latencies below 200 ms on task performance and subjective experience in laparoscopic surgery.
Performance Automotive Applications of Pressure-Sensitive Paint in the Langley Full Scale Tunnel (2002)

&lt;div class="htmlview paragraph"&gt;Recently, there has been a strong emphasis on aerodynamic and aeroacoustic wind tunnel testing of automobiles. While significant level resources have been spent on investigating aerodynamics, the methodology has not changed appreciably since the beginning of aerodynamics as a science. Over the past decade, a number of global flow diagnostic techniques have been developed that drastically increase the quality and quantity of data from wind tunnel testing. One of these technologies is the use of pressure sensitive luminescent coatings, known as pressure-sensitive paint, a method which has matured considerably since its inception and is now used extensively in aerospace applications with good results. The goal of this research is to implement this technology in the full scale testing of high performance automotive vehicles. This paper discusses the details of a preliminary test, such as technique, paint formulation, camera and lighting hardware, and data reduction and analysis. The test article was an actual high performance vehicle, a “stock car”, and the test facility was the Langley Full Scale Tunnel.&lt;/div&gt;
Continuous Curvilinear Capsulorhexis (1991)

Journal of Cataract & Refractive Surgery 17(1):p 110-111, January 1991. | DOI: 10.1016/S0886-3350(13)81001-2
{ital J}/{ital {psi}} and {ital {psi}}(2{ital S}) Production in p{bar p} Collisions at {radical}({ital s})=1.8 TeV (1997)

We present a study of J/{psi} and {psi}(2S) production in p{bar p} collisions, at {radical}(s)=1.8 TeV with the CDF detector at Fermilab. The J/{psi} and {psi}(2S) mesons are reconstructed using their {mu}{sup +}{mu}{sup {minus}} decay modes. We have measured the inclusive production cross section for both mesons as a function of their transverse momentum in the central region, {vert_bar}{eta}{vert_bar}{lt}0.6 . We also measure the fraction of these events originating from b hadrons. We thus extract individual cross sections for J/{psi} and {psi}(2S) mesons from b -quark decays and prompt production. We find a large excess (approximately a factor of 50) of direct {psi}(2S) production compared with predictions from the color singlet model. {copyright} {ital 1997} {ital The American Physical Society}
<title>Pulse width tuning by deflector system</title> (1999)

An electro-optic deflector system is developed to re-shape the optical pulse from a Q-switched Nd:YLF oscillator. The shaped optical pulses are tunable in pulse width by scanning the slit and optical pulses of sub 500 ps are obtained. Except the slit width, its position on the scanning plane also determines the shaped pulse width and even causes pulse distortion if the slit is located close to the edge of the scanned beam. The shortest pulse width can be achieved by this system is determined by the transform limitation. This electro-optic deflector system is successfully used in the SG-II high power laser facility.
Athletics for Pre-High School Age Children (1959)

(1959). Athletics for Pre-High School Age Children. Journal of Health, Physical Education, Recreation: Vol. 30, No. 9, pp. 19-44.
GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization (2000)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Large positive in-plane magnetoresistance induced by localized states at nanodomain boundaries in graphene (2017)

Graphene supports long spin lifetimes and long diffusion lengths at room temperature, making it highly promising for spintronics. However, making graphene magnetic remains a principal challenge despite the many proposed solutions. Among these, graphene with zig-zag edges and ripples are the most promising candidates, as zig-zag edges are predicted to host spin-polarized electronic states, and spin-orbit coupling can be induced by ripples. Here we investigate the magnetoresistance of graphene grown on technologically relevant SiC/Si(001) wafers, where inherent nanodomain boundaries sandwich zig-zag structures between adjacent ripples of large curvature. Localized states at the nanodomain boundaries result in an unprecedented positive in-plane magnetoresistance with a strong temperature dependence. Our work may offer a tantalizing way to add the spin degree of freedom to graphene.
Jamming and sensing of encrypted wireless ad hoc networks (2006)

This paper considers the problem of an attacker disrupting an encrypted victim wireless ad hoc network through jamming. Jamming is broken down into layers and this paper focuses on jamming at the Transport/Network layer. Jamming at this layer exploits AODV and TCP protocols and is shown to be very effective in simulated and real networks when it can sense victim packet types, but the encryption is assumed to mask the entire header and contents of the packet so that only packet size, timing, and sequence is available to the attacker for sensing. A sensor is developed and tested on live data. The classification is found to be highly reliable for many packet types. The relative roles of size, timing, and sequence are discussed along with the implications for making networks more secure.
Distortion analyses for temporal scalability coding techniques (2003)

A temporally scalable video coding algorithm allows extraction of video of multiple frame rates from a single coded stream. This paper compares the rate-distortion performance of three temporally scalable coding techniques: temporal subband coding (TSB), motion-compensated temporal subband coding (MC-TSB), and motion compensated prediction (MCP). The distortions are derived in terms of various temporal pixel correlations and the probability of occlusion. Measured values are used to predict performances at full and lower frame rates, and a comparison with experimental quantitative performances demonstrates that the performance ranking is correctly predicted and bounds the accuracy of the analyses at high rates. MCP and MC-TSB always outperform TSB. For high bit rate full-frame-rate video, MCP and MC-TSB perform equivalently. At lower frame rates, MCP provides better performance.
AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases (2016)

Non-small-cell lung cancer patients with activating mutations in epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitor (TKI) treatment. Nevertheless, patients often develop central nervous system (CNS) metastases during treatment, even when their extracranial tumors are still under control. In the absence of effective options, much higher doses of EGFR TKIs have been attempted clinically, with the goal of achieving high enough drug concentrations within the CNS. Although limited tumor responses have been observed with this approach, the toxicities outside the CNS have been too high to tolerate. We report the discovery and early clinical development of AZD3759, a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice. An early clinical study in patients with BM and LM treated with AZD3759 confirms its BBB-penetrant properties and antitumor activities. Our data demonstrate the potential of AZD3759 for the treatment of BM and LM and support its further clinical evaluation in larger trials.
Workforce preparation: the Biohealth computing model for Master and PhD students (2014)

The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiatives, like CASyM, fostering Systems Medicine at EU level. The chapter focuses on the BioHealth Computing Program as a reference for multidisciplinary training of future systems-oriented researchers describing the productive interactions with the Synergy-COPD project.
Right Coronary MR Angiography at 7 T: A Direct Quantitative and Qualitative Comparison with 3 T in Young Healthy Volunteers (2010)

In our quantitative and qualitative study comparing in vivo human imaging of the RCA at 7 T and 3 T in young healthy volunteers, parameters related to image quality attained at 7 T equal or surpass those from 3 T.