gebhart/patrepeval huggingface dataset:
High-density lipoprotein therapy inhibits Porphyromonas gingivalis-induced abdominal aortic aneurysm progression (2015)

Clinical and experimental studies have highlighted the potential implication of periondontal bacteria contamination in the pathogenesis of abdominal aortic aneurysms (AAA). In addition to their role in reverse cholesterol transport, high-density lipoproteins (HDLs) display multiple functions, including anti-inflammatory and lipopolysaccharide scavenging properties. Low plasma levels of HDL-cholesterol have been reported in AAA patients. We tested the effect of a HDL therapy in Sprague-Dawley rat model of AAA, obtained by intraluminal elastase infusion followed by repeated injections of Porphyromonas gingivalis (Pg). HDLs, isolated by ultracentrifugation of plasma from healthy human volunteers, were co-injected intravenously (10 mg/kg) with Pg (1.107 Colony Forming Unit) one, eight and 15 days after elastase perfusion. Rats were sacrificed one week after the last injection. Our results show that Pg injections promote the formation of a persistent neutrophil-rich thrombus associated with increased aortic diameter in this AAA model. HDLs significantly reduced the increased AAA diameter induced by Pg. Histology showed the onset of a healing process in the Pg/HDL group. HDL injections also reduced neutrophil activation in Pg-injected rats associated with decreased cytokine levels in conditioned media and plasma. Scintigraphic analysis showed an intense uptake of 99mTc-HDL by the AAA suggesting that HDLs could exert their beneficial effect by acting directly on the thrombus components. HDL supplementation may therefore constitute a new therapeutic tool for AAA treatment.
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone (1985)

Synthesis and opioid radioreceptor assay data on analogues closely related to 6-desoxy-6-spiro-alpha-methylene-gamma-lactone 5a, a compound with irreversible activity in this assay, are reported. Saturated lactones (7a,b), endocyclic alpha, beta-unsaturated gamma-lactones (8a,b and 9a), and 6 alpha,7 alpha-fused alpha-methylene-gamma-lactones (10a and 11a) were prepared. Related 6-desoxy-6-methylene 6 beta- and 6 alpha-oxides (12a,b and 13a) and glycidate esters 14a,b and 15a,b were also prepared with use of naltrexone (1a) and oxymorphone (1b) as starting material. Compounds in the N-cyclopropylmethyl (N-CPM) series were more potent than those in the N-Me series in displacing [3H]naltrexone in the opioid radioreceptor assay, usually by 2-16-fold in the absence of Na ion. The most potent N-CPM analogues were epoxides 12a and 13a and glycidate esters 14a and 15a, showing IC50's of 2-6 nM, similar to that of 5a. Of the N-Me analogues, 6 beta-oxide 12b was most active, with an IC50 of 8 nM in the absence of Na ion. For the N-CPM analogues, the Na ion ratios were generally less than 1, with two exceptions. The N-Me analogues showed expected larger Na ion effects of 7 or greater. None of the lactone analogues had irreversible effects when preincubated in the rat brain membrane preparation, even at 37 degrees C for 30 min, i.e., washing restored [3H]naltrexone binding to control levels. These results clearly show that the alpha-methylene-gamma-lactone moiety of 5a is required for irreversible effects, consistent with it serving as a conjugate addition acceptor of a nucleophilic group from a ligand at or near the receptor. The epoxides and glycidate esters also had no irreversible activity, indicating more electrophilic functional groups are needed and/or these electrophiles are not properly aligned to react with nucleophilic groups at or near the opioid receptor.
ARIMA time series modeling and forecasting for adaptive I/O prefetching (2001)

Bursty application I/O patterns, together with transfer limited storage devices, combine to create a major I/O bottleneck on parallel systems. This paper explores the use of time series models to forecast application I/O request times, then prefetching I/O requests during computation intervals to hide I/O latency. Experimental results with I/O intensive scientific codes show performance improvements compared to standard UNIX prefetching strategies.
Effective clearance of intracellular Leishmania majorin vivo requires Pten in macrophages (2008)

Leishmaniases are a major international public health problem, and macrophages are crucial for host resistance to this parasite. To determine if phosphatase and tensin homologue deleted on chromosome ten (Pten), a negative regulator of the PI3K pathway, plays a role in macrophage-mediated resistance to Leishmania, we generated C57BL/6 mice lacking Pten specifically in macrophages (LysMCrePten(flox/flox) mice). Examination of lesions resulting from Leishmania major infection showed that LysMCrePten(flox/flox) mice were more susceptible to the parasite than wild-type (WT) mice in the early phase of the infection, but were eventually able to eliminate the pathogen. In vitro Pten-deficient macrophages showed a reduced ability to kill parasites in response to IFN-gamma treatment, possibly because the mutant cells exhibited decreased TNF secretion that correlated with reductions in inducible nitric oxide synthase expression and nitric oxide production. In response to various TLR ligands, Pten-deficient macrophages produced less TNF and IL-12 but more IL-10 than WT cells. However, analysis of cells in the lymph nodes draining L. major inoculation sites indicated that both LysMCrePten(flox/flox) and WT mice developed normal Th1 responses following L. major infection, in line with the ability of LysMCrePten(flox/flox) mice to eventually eliminate the parasite. Our results indicate that the efficient clearance of intracellular parasites requires Pten in macrophages.
A Survey of Fitness-for-Service Trends in Industry (2011)

In 2002, TWI Ltd. carried out a questionnaire-based survey of “user experience of plant life management practices,” to gain a better understanding of the reality of plant life management and the needs of plant operators [Iravani and Speck, 2002, “Industry Survey of Risk Based Life Management Practices and Their Relationship to Fitness-for-Service Assessment,” TWI Report No. 13032/5/02]. In 2003, the European fitness-for-service network reported the results of their survey on “current application and future requirements for European fitness-for-service (FFS) technology” [Filiou et al. 2003, “Survey of Current Application and Future Requirements for European Fitness-for-Service Technology,” Technical Report No. FITNET/TR2/03, FITNET Consortium]. In 2006, the management of aging plant became a regulatory hot topic in the UK with a health and safety executive document on the subject being released [Health and Safety Executive, 2006, “Plant Ageing: Management of Equipment Containing Hazardous Fluids or Pressure,” RR509]. Considering also the recent release of the new API/ASME joint FFS standard [2007, API 579-1/ASME FFS-1, Fitness-For-Service, 1st ed., The American Petroleum Institute and the American Society of Mechanical Engineers, Washington, DC], TWI Ltd. decided 2007 was the ideal time to carry out an updated industry survey to assess how developments such as these might affect plant life management practices in different industry sectors across the world. The aims of this survey were to gain an insight into current FFS trends across several industry sectors and how these may change in the future. Information was gathered as to how different companies handle their FFS activities, both in terms of the types of flaw they assess and the complexity of the assessments they carry out. The survey also investigated how safety regulating authorities view FFS activities and whether or not they accept the results as the basis for plant integrity management decisions. Closely related to this is whether there is a need for better regulation of FFS activities, FFS training, or, indeed, whether FFS qualifications should be introduced. This paper presents the results of the online industry survey and draws pragmatic conclusions that will be of interest to all those involved with FFS activities, from inspectors to researchers and from engineers to insurers.
Diagnostic system for distributed software: A relational database approach (1984)

Software errors in distributed systems are difficult to detect, locate and correct. The relational database approach in software diagnostics is an integrated approach encompassing most features in static analysis, dynamic testing, symbolic execution and performance evaluation techniques. Modified syntax analysis of source program and testing run of the instrumented code generate the basis relations (symbol tables, graph models, program fragments, execution histories) from which diagnostic information is retrieved interactively. The basis relations contain necessary information to diagnose the software since data structures, algorithms and execution behavior of the software are included. Implementations of some typical dynamic testing features extended to distributed software are discussed and illustrated.
Role of Imaging Technics in the Classification of Acute Pancreatitis (1992)

This paper is a review of some aspects of acute pancreatitis (AP) (definition criteria, outcome, and prognostic factors) and a reminder of the invaluable contribution of computed tomography (CT) in confirming the diagnosis of AP, distinguishing between edematous and necrotizing forms, and in providing prognostic information via detection of possible extrapancreatic spreads (EPS). The Geneva experience (510 cases of AP over a 9-year period) has shown that no fatalities occurred when no EPS were found on CT performed within 48 h of admission; mortality was 1.5% in the case of 1 or 2 EPS and 19% in the case of 3 EPS or more.
138 Rapid growth electroforming technology for micromold fabrication in LIGA process (2003)

This paper involves the development of three-dimensional microstructure formation and rapid growth copper electroforming technology in LIGA process. The important contributions involve using multiple power supplies in parallel and air-pressure assistance for the electroforming system to enhance the electroforming rate. The proposed method enhances the allowable applied current density in electroforming. Rapid growth rate is produced in the electroforming process and good deposition material properties are maintained. high cathode efficiency and short plating time were also achieved. The experimental graphs demonstrated these results. The LIGA process involved here to form plastic micromolds for three-dimensional electroforming is also introduced. Graphite film is applied as the x-ray mask membrane, producing successful PMMA exposure at 1mm thick. This proposed electroforming technology has practical applications compared with previous studies on current waveform, electrical potential, agitation method, and electrolyte composition.
Rod and cone interactions in the retina (2018)

We have long known that rod and cone signals interact within the retina and can even contribute to color vision, but the extent of these influences has remained unclear. New results with more powerful methods of RNA expression profiling, specific cell labeling, and single-cell recording have provided greater clarity and are showing that rod and cone signals can mix at virtually every level of signal processing. These interactions influence the integration of retinal signals and make an important contribution to visual perception.
Mechanical and servo design of a 10 inch disk drive (1981)

Design concepts of the mechanical and servo system of a newly-developed compact disk drive are discussed. This new drive features 10 inch diameter disks with a capacity above 400 Mega-bytes. The mechanical structure, with its own closed self-circulating air system , is designed to minimize thermal offtrack and undesired vibration. A new rotary type head actuator is accommodated, and servo system design is based on an optimal control theory to achieve fast, precise positioning.
Novel Mold Fabrication for Nano-Imprint Lithography to Fabricate Single-Electron Tunneling Devices (1999)

A novel method of fabricating a nano-imprinting mold for a single-electron device is newly proposed, which makes use of the peculiarity of anisotropic wet chemical etching. A row of resist patterns for quantum dots is placed to keep an offset angle θ against a &lt;110&gt; crystalline axis on a (100) Si surface. By an anisotropic wet chemical etching, the Si substrate is diagonally etched along the &lt;110&gt; and &lt;110&gt; directions, and an inverted pyramidal hole with a (111) plane surface is formed. The gap between them becomes narrower than that of the original pattern. Using this method, the nano-imprinting mold for a quantum dot array with narrow gaps beyond the resolution limit of conventional lithography is obtained.
Luminescence of Polyethylene Glycol Coated CdSeTe/ZnS and InP/ZnS Nanoparticles in the Presence of Copper Cations (2011)

The use of click chemistry for quantum dot (QD) functionalization could be very promising for the development of bioconjugates dedicated to in vivo applications. Alkyne-azide ligation usually requires copper(I) catalysis. The luminescence response of CdSeTe/ZnS nanoparticles coated with polyethylene glycol (PEG) is studied in the presence of copper cations, and compared to that of InP/ZnS QDs coated with mercaptoundecanoic acid (MUA). The quenching mechanisms appear different. Luminescence quenching occurs without any wavelength shift in the absorption and emission spectra for the CdSeTe/ZnS/PEG nanocrystals. In this case, the presence of copper in the ZnS shell is evidenced by energy-filtered transmission electron microscopy (EF-TEM). By contrast, in the case of InP/ZnS/MUA nanocrystals, a redshift of the excitation and emission spectra, accompanied by an increase in absorbance and a decrease in photoluminescence, is observed. For CdSeTe/ZnS/PEG nanocrystals, PL quenching is enhanced for QDs with 1) smaller inorganic-core diameter, 2) thinner PEG shell, and 3) hydroxyl terminal groups. Whereas copper-induced PL quenching can be interesting for the design of sensitive cation sensors, copper-free click reactions should be used for the efficient functionalization of nanocrystals dedicated to bioapplications, in order to achieve highly luminescent QD bioconjugates.
Nickel‐induced keratinocyte proliferation and up‐modulation of the keratinocyte growth factor receptor expression (2003)

Keratinocytes play a key role in the pathogenesis of allergic contact dermatitis (ADC) induced by the sensitizing agent nickel. We analyzed here the effects of treatment with nickel and of the pretreatment with zinc on HaCaT cells and primary human keratinocytes. Cell counting, 5-bromo-2'-deoxyuridine incorporation assay and adenosine triphosphate (ATP) bioluminescence detection showed that treatment with NiSO4 induced DNA synthesis and cell proliferation and that pretreatment with ZnSO4 was able to abrogate this proliferative effect. This nickel-induced cell growth appeared enhanced when primary human keratinocytes were co-cultured with fibroblasts. Western blot analysis demonstrated that nickel ions induced up-modulation of the expression of the keratinocyte growth factor receptors (KGFR) without affecting the keratinocyte differentiation, whereas the protein levels of the epidermal growth factor receptor (EGFR) and of its ligand transforming growth factor-alpha (TGF-alpha) appeared unmodified by the treatment. Double immunofluorescence showed that the effect of nickel on DNA synthesis was mainly exerted on KGFR expressing cells, suggesting that KGFR up-modulation could be required for the nickel-induced cell proliferation. These results indicate that KGFR and its ligands may play a role in the mechanism of action of nickel ions and in the protective effect of zinc pretreatment.
Bimodal spatial distribution of macular pigment: evidence of a gender relationship (2006)

The spatial distribution of the optical density of the human macular pigment measured by two-wavelength autofluorescence imaging exhibits in over half of the subjects an annulus of higher density superimposed on a central exponential-like distribution. This annulus is located at about 0.7 degrees from the fovea. Women have broader distributions than men, and they are more likely to exhibit this bimodal distribution. Maxwell's spot reported by subjects matches the measured distribution of their pigment. Evidence that the shape of the foveal depression may be gender related leads us to hypothesize that differences in macular pigment distribution are related to anatomical differences in the shape of the foveal depression.
Role of MUC1 in idiopathic pulmonary fibrosis: mechanistic insights (2017)

<b>Background:</b> Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible form of fibrotic interstitial lung disease. MUC1, a membrane-bound O-glycoprotein, is considered as oncogenic molecule by altering signaling pathways involved in cellular processes related to IPF. In previous studies we have observed an up-regulation of MUC1 and its phosphorylated forms in IPF lung tissue. However the exact participation of MUC1 in IPF is currently unknown. <b>Objective:</b> To analyze the mechanism of MUC1-induced lung fibrosis in different cellular and animal models of IPF. <b>Methods:</b> The intracellular mechanism of MUC1 was evaluated by western blot, immunoprecipation and immunofluorescence in alveolar type II A549 and fibroblast MRC5, and IPF primary alveolar type II epithelial cells and lung fibroblasts. Cells were stimulated with TGFβ1. Lung tissue from human healthy/IPF and bleomycin-induced IPF mice wild type/ knockout MUC1 (KO-MUC1) was analyzed to explore MUC1 intracellular interactions by immunofluorescence. <b>Results:</b> Western blot indicated that TGFβ1 activated β-catenin and p-Smad2/3, which phosphorylated and activated MUC1 cytoplasmic tail (CT) at 1224 and 1229 treonin and tirosin residues. Immunoprecipitation and immunofluorescence studies showed that the multi-protein complex among pSmad2/3, β-catenin and MUC1-CT migrated into the nucleus to activate fibrotic genes in human cells and human and animal lung tissue. Unlike wild type mice, KO-MUC1 mice were protected against IPF, improving lung function, survival and fibrotic lung tissue remodeling. <b>Conclusions:</b> MUC1-CT collaborates with TGFβ1 to induce IPF progression. Therefore, pharmacologic targeting of MUC1-CT may be a promising option for the treatment of IPF.
Fractal growth in uv-irradiated DNA: Evidence of nonuniversal diffusion limited aggregation (1995)

Branched structures and fractals occur widely in nature (trees, corals, sand dunes, etc.) showing its preference for nonintegral dimensionality characteristic of nonequilibrium growth phenomena [B. B. Mandelbrot, The Fractal Geometry of Nature (Freeman, New York, 1982)]. Neural networks, blood platelets, some cancerous growth patterns, etc. are also known examples of fractals in physiological systems. Many theoretical models have been invoked to explain different fractal and ramified structures [T. Vicsek, Fractal Growth Phenomena (World Scientific, Singapore, 1989)]. The diffusion limited aggregation (DLA) of particles in a random walk that was computer simulated by Witten and Sander [T. A. Witten and L. M. Sander, Phys. Rev. Lett. 47, 1400 (1981)] is a more universal mechanism. Recently, a nonuniversal DLA has been theoretically proposed [P. Ossadnik, C. Lam, and L. M. Sander, Phys. Rev. E 49, 1788 (1994)] where particles in a random walk are not of the same size. This paper reports the significant observation that uv-photolyzed DNA in an alkaline solution aggregates, on drying, in a fractal-like structure. Furthermore, this observation provides experimental confirmation of nonuniversal diffusion limited aggregation [P. Ossadnik, C. Lam, and L. M. Sander, Phys. Rev. E 49, 1788 (1994)].
Volatile Organic Compound Determinations Using Surrogate-Based Correction for Method and Matrix Effects (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolatile Organic Compound Determinations Using Surrogate-Based Correction for Method and Matrix EffectsMichael H. Hiatt and Carole M. FarrCite this: Anal. Chem. 1995, 67, 2, 426–433Publication Date (Print):January 15, 1995Publication History Published online1 May 2002Published inissue 15 January 1995https://pubs.acs.org/doi/10.1021/ac00098a031https://doi.org/10.1021/ac00098a031research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Infrared spectroscopy of Li2MnSiO4: A cathode material for Li ion batteries (2015)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Mukesh Pandey, Vishwanathan Ramar, Palani Balaya, Rohidas J. Kshirsagar; Infrared spectroscopy of Li2MnSiO4: A cathode material for Li ion batteries. AIP Conf. Proc. 24 June 2015; 1665 (1): 140044. https://doi.org/10.1063/1.4918253 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Evaluation of cotton polyphenols as factors of resistance to root-knot nematode and Fusarium wilt (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of cotton polyphenols as factors of resistance to root-knot nematode and Fusarium wiltPaul A. Hedin, Raymond L. Shepherd, and A. J. Kappelman Jr.Cite this: J. Agric. Food Chem. 1984, 32, 3, 633–638Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/jf00123a052https://doi.org/10.1021/jf00123a052research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts