gebhart/patrepeval huggingface dataset:
Success and complication rate of Tightrail mechanical percutaneous lead extraction: a multicenter French study (2020)

Abstract Background Our objective was to assess Philips TightRail™ rotating dilator sheath efficacy and safety for extraction of endocardial leads. No large scale multicenter data is available on this mechanical lead extraction device, now commonly used in France. Methods and results We conducted a retrospective, multicenter (from 4 French university hospitals) study. These centers that only perform mechanical lead extraction using this device were selected on the basis of the annual volume of procedures (&amp;gt;10 leads/year). All patients from January 2015 to January 2020 who underwent at least one extraction of an endocardial lead with using TightRail™ were included. All of the extracted leads were &amp;gt;12 months old and indications for extraction were based on ESC guidelines. Overall, 395 leads were extracted using TightRail™ in 203 patients (mean age 70 years, 75% male sex). Indications for lead removal included cardiac device infection in 172 (85%) cases, lead malfunction in the 25 (12%) cases, vein thrombosis in 3 (1.5%) cases and 3 for other indications (1,5%). The extracted devices were pacemaker in 134 (66%) cases, implantable cardioverter-defibrillator (ICD) in 69 (44%) cases. The mean time from implantation was 124 months. Complete procedural success with TightRail™ system alone was achieved in 180 (89.1%) patients (352 leads) and overall clinical success was 93% (367 leads). Fifteen right sided leads were completely removed with the help of femoral snare. Ten (5%) patients had at least one major perioperative complication: 3 cardiac tamponades, 1 haemothorax, 1 stroke, 5 vascular breaches requiring surgical intervention. No in-hospital death was observed. Conclusion Our large scale retrospective study in 4 high-volume mechanical lead extraction centers shows that TightRail™ is highly effective for chronically implanted lead extraction. The safety profile appears similar to the rate recently described with power sheaths. Funding Acknowledgement Type of funding source: None
Continuous release of hepatitis C virus (HCV) by peripheral blood mononuclear cells and B-lymphoblastoid cell-line cultures derived from HCV-infected patients (2005)

In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood mononuclear cells (PBMC) from a group of haemophilic individuals, HCV production and release to PBMC culture supernatants (SNs) from HCV singly infected patients and HIV/HCV co-infected patients was studied. HCV RNA+ SNs were found more frequently from HIV/HCV co-infected individuals (89.5 %) with poor reconstitution of their immune status than from singly HCV-infected patients (57 %) or from HIV/HCV co-infected individuals with a good response to highly active anti-retroviral therapy (50 %). The presence of the HCV genome in culture SNs was associated with lower CD4+ T-cell counts and with a more severe clinical picture of HIV infection. In spite of prolonged negative HCV viraemia, PBMC from HIV/HCV co-infected patients released the HCV genome after culture. HCV permissive PBMC allowed generation of HCV productive B cell lines with continuous HCV replication. These findings add further weight to the involvement of PBMCs in persistence of HCV infection and emphasize the role of B lymphocytes as HCV reservoirs.
Acid‐Promoted Chemoselective Introduction of Amide Functionality onto Aromatic Compounds Mediated by an Isocyanate Cation Generated from Carbamate (2014)

Carbamates have been used as precursors of isocyanates, but heating in the presence of strong acids is required because cleavage of the C-O bond in carbamates is energy-demanding even in acid media. Direct amidation of aromatic compounds by isocyanate cations generated at room temperature from carbamoyl salicylates in trifluoromethanesulfonic acid (TfOH) was examined. Carbamates with ortho-salicylate as an ether group (carbamoyl salicylates) showed dramatically accelerated O-C bond dissociation in TfOH, which resulted in facile generation of the isocyanate cation. These chemoselective intermolecular aromatic amidation reactions proceeded even at room temperature and showed good compatibility with other electrophilic functionalities and high discrimination between N-monosubstituted carbamate and N,N-disubstituted carbamate. The reaction rates of secondary and tertiary amide formation were markedly different, and this difference was utilized to achieve successive (tandem) amidation reactions of molecules with an N-monosubstituted carbamate and an N,N-disubstituted carbamate with two kinds of aromatic compounds.
Resveratrol‐induced apoptosis is enhanced in low pH environments associated with cancer (2011)

Many critical factors such as hypoxia, nutrient deficiency, activation of glycolytic pathway/Warburg effect contribute to the observed low pH in tumors compared to normal tissue. Studies suggest that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. Independent observations show reduction in pH of mammalian cells undergoing internucleosomal DNA fragmentation and apoptosis. As such, our group has extensively demonstrated that anticancer mechanisms of different plant polyphenols involve mobilization of endogenous copper and consequent internucleosomal DNA breakage. Copper is redox active metal, an essential component of chromatin and is sensitive to subtle pH changes in its microenvironment. Here we explored whether, acidic pH promotes growth inhibition, apoptosis, and DNA damaging capacity of chemopreventive agent resveratrol. Our results reveal that growth inhibition and internucleosomal DNA fragmentation induced apoptosis in Capan-2 and Panc-28 pancreatic cancer cell lines (and not in normal HPDE cells) by resveratrol is enhanced at lower pH. Using comet assay, we further demonstrate that DNA breakage by resveratrol is enhanced with acidification. Membrane permeable copper specific chelator neocuproine (and not iron chelator orthophenanthroline) abrogated growth inhibition and apoptosis by resveratrol. Western blot results show enhanced activation of DNA laddering marker H2.aX by resveratrol at acidic pH that was reversed by neocuproine and not by orthophenanthroline. Our findings provide irrevocable proof that low pH environment can be turned into tumor weakness and assist in eradication of cancer cells by resveratrol.
The archaeology of mind: neuroevolutionary origins of human emotions (2013)

What makes us happy? What makes us sad? How do we come to feel a sense of enthusiasm? What fills us with lust, anger, fear, or tenderness? Traditional behavioral and cognitive neuroscience have yet to provide satisfactory answers. The Archaeology of Mind presents an affective neuroscience approach-which takes into consideration basic mental processes, brain functions, and emotional behaviors that all mammals share-to locate the neural mechanisms of emotional expression. It reveals-for the first time-the deep neural sources of our values and basic emotional feelings. This book elaborates on the seven emotional systems that explain how we live and behave. These systems originate in deep areas of the brain that are remarkably similar across all mammalian species. When they are disrupted, we find the origins of emotional disorders: - SEEKING: how the brain generates a euphoric and expectant response - FEAR: how the brain responds to the threat of physical danger and death - RAGE: sources of irritation and fury in the brain - LUST: how sexual desire and attachments are elaborated in the brain - CARE: sources of maternal nurturance - GRIEF: sources of non-sexual attachments - PLAY: how the brain generates joyous, rough-and-tumble interactions - SELF: a hypothesis explaining how affects might be elaborated in the brain The book offers an evidence-based evolutionary taxonomy of emotions and affects and, as such, a brand-new clinical paradigm for treating psychiatric disorders in clinical practice.
The concentration profiles of projectiles and recoiled nitrogen in Si after ion implantation through Si3N4 films (1979)

The concentration profiles of ion-implanted boron, phosphorus, and arsenic, and recoil-implanted nitrogen atoms after ion implantation through Si3N4 films on Si have been measured using secondary ion mass spectrometry. The concentration profiles of the implanted ions in Si after ion implantation through Si3N4 films were found to agree with those implanted into bare Si within experimental errors, with the exception of a shifting of the concentration peak position. The concentration profiles of recoil-implanted nitrogen in Si are generally composed of high-concentration regions with steeply decaying distributions near the silicon surface and the exponential tails whose slopes are independent of ion mass, energy, dose, and film thickness. The concentration level of recoil-implanted nitrogen and maximum penetration range relative to the implanted ion range depend strongly on ion mass, film thickness, and ion energy. It was demonstrated that the concentration profiles for recoiled nitrogen in Si calculated using the Thomas-Fermi interaction potential agree better with the measured profiles than those calculated using 1/r2 potential, such as presented in the theory by Moline et al.
A global approach to manipulability optimisation for a dual-arm manipulator (2016)

In this paper, we present a new approach to manipulability maximisation for a dual-arm manipulator, which takes into account the manipulability of the overall task. This method tries to overcome the drawbacks given by traditional approaches, which optimise the manipulability of the local configuration of the manipulator, but do not take into account the rest of the task, even though it is known a priori. In this way, it is possible to improve the average manipulability index over the task. The method is applied to a dual-arm system, wherein the task is expressed in terms of relative poses between the end-effectors. For this reason, the kinematic of the system is solved by means of the relative Jacobian.
Transmetalation Reactions Producing Organocopper Reagents (2002)

Introduction Transmetalation of Functionalized Organolithium and Organomagnesium Reagents Transmetalation of Organoboron and Organoaluminium Reagents Transmetalation of Functionalized Organozinc Reagents Preparation of Organozinc Reagents Preparation of Organozinc Halides Preparation of Diorganozinc Reagents Substitution Reactions with Copper-Zinc Reagents Addition Reactions with Copper-Zinc Reagents Transmetalation of Organotin, Organosulfur, and Organotellurium Reagents Transmetalation of Organotitanium and Organomanganese Reagents Transmetalation of Organozirconium and Organosamarium Reagents Conclusion
A Useful Procedure for the Preparation of (E,E)-2,4-Dienoates: Lithium Hydroxide-Promoted Dienylation by 4-Phosphonocrotonate (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Useful Procedure for the Preparation of (E,E)-2,4-Dienoates: Lithium Hydroxide-Promoted Dienylation by 4-PhosphonocrotonateJames M. Takacs, Mohamad R. Jaber, Francis Clement, and Carol WaltersView Author Information Department of Chemistry, University of NebraskaLincoln, Lincoln, Nebraska 68588-0304 Cite this: J. Org. Chem. 1998, 63, 19, 6757–6760Publication Date (Web):August 28, 1998Publication History Received4 May 1998Published online28 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/jo980841chttps://doi.org/10.1021/jo980841cbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views449Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Analytical apparatus,Ketones,Oxidation,Oxidation reactions Get e-Alerts
File storage management for TFTR physics data (2002)

The desire to maintain ready access to data files covering the entire history of Tokamak Fusion Test Reactor (TFTR) has created a need for more economical methods of mass storage. This need was addressed through a combined hardware and software approach. This involved the purchase of a SONY optical disk subsystem with an auto changer (the 'Jukebox') which provides 160 Gbytes of online storage. The software constitutes a transparent layer integrating the Jukebox into the existing data file access methods. The system caches files on magnetic disks, which are managed automatically, so that they never exceed capacity. Newly created files are copied to the Jukebox for long-term storage and to magnetic tapes for backup purposes. The data remain on magnetic disks until a need for more space causes them to be skimmed according to frequency of use. Users can access any skimmed file just as though it were still on the magnetic cache. The system restores the file transparently within seconds, without need for manual intervention.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Detection of Oligonucleotides by External Injection into an Ion Trap Storage/Reflectron Time-of-flight Device (1997)

The detection of oligonucleotides has been studied using external injection of Matrix-assisted laser desorption/ionization (MALDI) produced ions into a quadrupole ion trap storage device. The ions stored in the trap are then detected by pulsed DC injection into a reflection time-of-flight mass spectrometer. It is shown that by using a low acceleration voltage from the probe tip and external injection into the trap that 3-mers to 9-mers can be stored for 20-50 ms and detected as intact ions. In comparison, direct MALDI inside the trap resulted in extensive fragmentation as a function of storage time. Using the external injection with a He buffer gas in the trap yields a resolution of 250-400 in the ion trap storage/reflectron time-of-flight mass spectrometer. The resolution can be further enhanced to 400-800 using a bipolar extraction method. In addition, the trapping efficiency for the injection of externally produced ions into the trap can be enhanced using a dynamic trapping method. The MALDI mass spectra produced by this methodology result in excellent signal-to-noise ratio due to the capabilities of the trap for eliminating low mass matrix background from the spectra.
Reducing intrinsic loss in superconducting resonators by surface treatment and deep etching of silicon substrates (2015)

We present microwave-frequency NbTiN resonators on silicon, systematically achieving internal quality factors above 1 M in the quantum regime. We use two techniques to reduce losses associated with two-level systems: an additional substrate surface treatment prior to NbTiN deposition to optimize the metal-substrate interface and deep reactive-ion etching of the substrate to displace the substrate-vacuum interfaces away from high electric fields. The temperature and power dependence of resonator behavior indicate that two-level systems still contribute significantly to energy dissipation, suggesting that more interface optimization could further improve performance.
Variable sensitivity of organic light-emitting diodes to operation-induced chemical degradation: Nature of the antagonistic relationship between lifetime and efficiency (2010)

The efficiency of any organic light-emitting diode (OLED) decreases with prolonged operation. In fluorescent OLEDs containing the standard hole-transporting material NPB [N,N′-diphenyl-N,N′-bis(1-naphthyl)-1,1′-biphenyl-4,4′-diamine], prolonged operation also results in chemical degradation of the NPB. Qualitatively and quantitatively, the extent and location of chemical changes are consistent with the hypothesis that chemical degradation of NPB is largely responsible for the loss of device efficiency and that the degradation is initiated by bond-breaking in excited-state NPB. Blue fluorescent OLEDs with low operating voltages and high luminance efficiencies tend to lose efficiency much faster than OLEDs with higher operating voltages and lower efficiencies. Even so, the two types exhibit approximately the same kind and degree of chemical degradation after operation for equal times at equal current densities. In the low-voltage OLEDs, the electric field in the light-emitting layer is weaker, and the concentration of NPB radical-cations near the emission zone is smaller than in the higher-voltage devices. Apparently for this reason, degradation products impair the luminescent efficiency more severely in the low-voltage OLEDs. Such differing sensitivity of low-voltage and high-voltage OLEDs to the same amount of chemical degradation is further demonstrated by experiments with OLEDs that have been doped intentionally with a contaminant modeling a degradation product at realistic concentrations. It is also supported by a substantial recovery of efficiency after a conversion of a degraded low-voltage device into a high-voltage device by replacement of the cathode and electron-injecting interface.
Association of Herpesvirus Saimiri Tip with Lipid Raft Is Essential for Downregulation of T-Cell Receptor and CD4 Coreceptor (2005)

ABSTRACT Lipid rafts are membrane microdomains that are proposed to function as platforms for both receptor signaling and trafficking. Our previous studies have demonstrated that Tip of herpesvirus saimiri (HVS), which is a T-lymphotropic tumor virus, is constitutively targeted to lipid rafts and interacts with cellular Lck tyrosine kinase and p80 WD repeat-containing endosomal protein. Through the interactions with Lck and p80, HVS Tip modulates diverse T-cell functions, which leads to the downregulation of T-cell receptor (TCR) and CD4 coreceptor surface expression, the inhibition of TCR signal transduction, and the activation of STAT3 transcription factor. In this study, we investigated the functional significance of Tip association with lipid rafts. We found that Tip expression remarkably increased lipid raft fractions in human T cells by enhancing the recruitment of lipid raft-resident proteins. Genetic analysis showed that the carboxyl-terminal transmembrane, but not p80 and Lck interaction, of Tip was required for the lipid raft localization and that lipid raft localization of Tip was necessary for the efficient downregulation of TCR and CD4 surface expression. Correlated with this, treatment with Filipin III, a lipid raft-disrupting agent, effectively reversed the downregulation of CD3 and CD4 surface expression induced by Tip. On the other hand, Tip mutants that were no longer present in lipid rafts were still capable of inhibiting TCR signaling and activating STAT3 transcription factor activity as efficiently as wild-type (wt) Tip. These results indicate that the association of Tip with lipid rafts is essential for the downregulation of TCR and CD4 surface expression but not for the inhibition of TCR signal transduction and the activation of STAT3 transcription factor. These results also suggest that the signaling and targeting activities of HVS Tip rely on functionally and genetically separable mechanisms, which may independently modulate T-cell function for viral persistence or pathogenesis.
Grap— a language for typesetting graphs. Tutorial and user manual (1990)

Grap is a language for describing plots of data. This graph of the 1984 age distribution in the United States 0 20 40 60 80 0 1 2 3 4 5 Population (in millions) 1984 Age is produced by the grap commands coord x 0,89 y 0,5 label left &amp;quot;Population&amp;quot; &amp;quot;(in millions)&amp;quot; label bottom &amp;quot;1984 Age&amp;quot; draw solid copy &amp;quot;agepop.d&amp;quot; (Each line in the data file agepop.d contains an age and the number of Americans of that age alive in 1984; the file is sorted by age.) The grap preprocessor works with pic [4] and troff [5]. Most of its input is passed through untouched, but statements between .G1 and .G2 are translated into pic commands that draw graphs. Revised, May Grap --- A Language for Typesetting Graphs Tutorial and User Manual Jon L. Bentley Brian W. Kernighan AT&amp;amp;T Bell Laboratories Murray Hill, New Jersey 07974 1. Introduction Grap is a language for describing graphical displays of data. It provides such services as automatic scaling and labeling of axes, and for statements, if statements, and m...
Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase (2010)

AMP-activated protein kinase (AMPK), a serine/threonine kinase activated upon energy depletion, stimulates energy production and limits energy utilization. It has previously been shown to enhance cellular glucose uptake through the GLUT family of facilitative glucose transporters. The present study explored the possibility that AMPK may regulate Na+-coupled glucose transport through SGLT1 (SLC5A1). To this end, SGLT1 was expressed in Xenopus oocytes with and without AMPK and electrogenic glucose transport determined by dual electrode voltage clamping experiments. In SGLT1-expressing oocytes but not in oocytes injected with water or expressing constitutively active (gammaR70Q)AMPK (alpha1beta1gamma1(R70Q)) alone, the addition of glucose to the extracellular bath generated a current (I(g)), which was half maximal (K(M)) at approximately 650 microM glucose concentration. Coexpression of (gammaR70Q)AMPK did not affect K(M) but significantly enhanced the maximal current (approximately 1.7 fold). Coexpression of wild type AMPK or the kinase dead (alphaK45R)AMPK mutant (alpha1(K45R)beta1gamma1) did not appreciably affect I(g). According to confocal microscopy and Western Blotting, AICAR (1 mM), phenformin (1 mM) and A-769662 (10 microM) enhanced the SGLT1 protein abundance in the cell membrane of Caco2 cells suggesting that AMPK activity may increase membrane translocation of SGLT1. These observations support a role for AMPK in the regulation of Na+-coupled glucose transport.