gebhart/patrepeval huggingface dataset:
Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles (2021)

Air pollution exposure during pregnancy may be a risk factor for altered immune maturation in the offspring. We investigated the association between ambient air pollutants during pregnancy and cell populations in cord blood from babies born to mothers with asthma enrolled in the Breathing for Life Trial. For each patient (<i>n</i> = 91), daily mean ambient air pollutant levels were extracted during their entire pregnancy for sulfur dioxide (SO<sub>2</sub>), nitric oxide, nitrogen dioxide, carbon monoxide, ozone, particulate matter <10 μm (PM<sub>10</sub>) or <2.5 μm (PM<sub>2.5</sub>), humidity, and temperature. Ninety-one cord blood samples were collected, stained, and assessed using fluorescence-activated cell sorting (FACS). Principal Component (PC) analyses of both air pollutants and cell types with linear regression were employed to define associations. Considering risk factors and correlations between PCs, only one PC from air pollutants and two from cell types were statistically significant. PCs from air pollutants were characterized by higher PM<sub>2.5</sub> and lower SO<sub>2</sub> levels. PCs from cell types were characterized by high numbers of CD8 T cells, low numbers of CD4 T cells, and by high numbers of plasmacytoid dendritic cells (pDC) and low numbers of myeloid DCs (mDCs). PM<sub>2.5</sub> levels during pregnancy were significantly associated with high numbers of pDCs (<i>p</i> = 0.006), and SO<sub>2</sub> with high numbers of CD8 T cells (<i>p</i> = 0.002) and low numbers of CD4 T cells (<i>p</i> = 0.011) and mDCs (<i>p</i> = 4.43 × 10<sup>-6</sup>) in cord blood. These data suggest that ambient SO<sub>2</sub> and PM<sub>2.5</sub> exposure are associated with shifts in cord blood cell types that are known to play significant roles in inflammatory respiratory disease in childhood.
Evaluation of a home-based 7-day infection control strategy for healthcare workers following high-risk exposure to severe acute respiratory coronavirus virus 2 (SARS-CoV-2): A cohort study (2020)

Among HCWs with high-risk exposure to SARS-CoV-2, a home-based 7-day infection control strategy may have a high NPV for subsequent COVID-19 and asymptomatic SARS-CoV-2 detection. Ongoing data collection and data sharing are needed to improve the precision of the estimated NPV, and here we report interim results to inform infection control strategies in light of a second wave threatening this essential workforce.
A fast VSELP speech coder based on mutually orthonormal regular pulse vectors (2002)

A new vector sum excited linear prediction (VSELP) speech coder employing mutually orthonormal regular pulse vectors is presented. Since the algorithm uses an efficient vector-sum codebook consisting of mutually orthonormal regular pulse basis vectors, computational load for codebook search can be significantly reduced, while the reconstructed speech quality is equivalent to that of the conventional VSELP. The method, referred to as regular pulse VSELP (RP-VSELP), employs the Gram-Schmidt (GS) procedure to orthonormalize the basis vectors designed in a form of regular pulses. To enhance the SNR performance, the basis vectors are optimized using an iterative closed-loop training process.
Figure S1-S8 from Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells (2023)

&lt;p&gt;Figure S1-S8&lt;/p&gt;
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems (2020)

Current practices in drug development have led to therapeutic compounds being approved for widespread use in humans, only to be later withdrawn due to unanticipated toxicity. These occurrences are largely the result of erroneous data generated by in vivo and in vitro preclinical models that do not accurately recapitulate human physiology. Herein, a human primary cell- and stem cell-derived 3D organoid technology is employed to screen a panel of drugs that were recalled from market by the FDA. The platform is comprised of multiple tissue organoid types that remain viable for at least 28 days, in vitro. For many of these compounds, the 3D organoid system was able to demonstrate toxicity. Furthermore, organoids exposed to non-toxic compounds remained viable at clinically relevant doses. Additional experiments were performed on integrated multi-organoid systems containing liver, cardiac, lung, vascular, testis, colon, and brain. These integrated systems proved to maintain viability and expressed functional biomarkers, long-term. Examples are provided that demonstrate how multi-organoid 'body-on-a-chip' systems may be used to model the interdependent metabolism and downstream effects of drugs across multiple tissues in a single platform. Such 3D in vitro systems represent a more physiologically relevant model for drug screening and will likely reduce the cost and failure rate associated with the approval of new drugs.
Analysis of quasi-static scheduling techniques in a virtualized reconfigurable machine (2002)

The SCORE compute model uses fixed-size, virtual compute and memory pages connected by stream links to capture the definition of a computation abstracted from the detailed size of the physical hardware. When the number of physical compute pages is smaller than the number of virtual compute pages in the abstract computation graph, the design is time-multiplexed onto the available physical hardware. A key component of this strategy is an automatic scheduler that selects the temporal sequencing of virtual resources onto the physical device. We describe a quasi-static scheduling strategy that retains the full semantic power of the dynamic SCORE flow graph while taking advantage of static scheduling techniques at program load time to hoist most of the computational work out of the inner scheduling loops. This strategy reduces online scheduling work per reconfiguration epoch by an order of magnitude. In addition, a more global perspective available from offline-scheduling improves schedule quality, resulting in a net reduction of total execution time by 46--81%.
New Contingency Program Paradigm (2012)

Contingency programs are needed to prevent and protect against the impact and consequence of an unplanned disaster, regardless of its cause. The emergence of terrorism and threat of workplace violence demands that boards of directors insist that organizations develop and periodically report on initiatives to identify and take corrective action to eliminate conditions or policies that might encourage terrorism or workplace violence, and develop preventive programs for working with employees who display symptoms consistent with profiles of workplace violence offenders. Organizations successful in implementing cost-effective contingency programs have predominantly delegated responsibility to human resources (HR). Information systems computer disaster recovery plan budgets were transferred to HR. All contingency program expenditures were justified and administered by HR. The focus of the new paradigm is the need to maintain business continuity functions for mission-critical facilities. “Facilities” includes corporate headquarters, manufacturing plants, and distribution centers.
Safety and Reliability Assessment on Products and Organisations (1998)

One of the more recent developments in the field of Reliability and safety is the realization that these aspects are not only a function of the product itself but also of the organization realizing this product. A second development is a trend from an often predominantly qualitative analysis towards a quantitative analysis. This can be illustrated by comparing aspects covered in the (older) DIN 19250 and the (more recent) IEC61508. In contrast to the DIN 19250, the IEC61508 requires, on product level, also a quantitative analysis and, on organizational level, an assessment on the (maturity of the-) business processes in an organization and how these processes are maintained. This paper presents: A method, called MIR (Maturity Index on Reliability) to quantify the organizational maturity of an organization. This method is derived from existing methods in the consumer electronics industry, The application of the MIR method in an actual, Industrial, case. The paper will discuss not only the practical application of IEC61508 in an Industrial organization but will also explain the underlying models and theory that is needed to come to an unambiguous IEC61508 certification
Spiro Compounds for Organic Optoelectronics (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpiro Compounds for Organic OptoelectronicsTobat P. I. Saragi, Till Spehr, Achim Siebert, Thomas Fuhrmann-Lieker, and Josef SalbeckView Author Information Macromolecular Chemistry and Molecular Materials (mmCmm), Institute of Chemistry, Department of Science and Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Strasse 40, D-34109 Kassel, Germany Cite this: Chem. Rev. 2007, 107, 4, 1011–1065Publication Date (Web):March 24, 2007Publication History Received31 October 2006Published online24 March 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/cr0501341https://doi.org/10.1021/cr0501341research-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views13932Altmetric-Citations892LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Materials,Oxidation,Reaction products,Thin films Get e-Alerts
Tracing a 14C‐labeled carbamate molluscicide through the digestive system of deroceras reticulatum (müller) (1990)

Abstract The passage of a 14 C‐labeled carbamate, 2‐(2‐chloro‐1‐methoxy‐' ethoxy)phenyl N‐methylcarbamate, or its labeled metabolites through the alimentary system of the grey garden slug Deroceras reticulatum was examined by autoradiographic studies and scintillation counting. It was demonstrated that, in a first step, the molluscicide penetrated the cells of the oesophagus and the crop. It was quickly transported by the hemolymph to the periphery of the body and re‐entered the cells of the digestive tract and the mid‐gut gland in a second step from the hemolymph side. The crypt cells of the mid‐gut gland are discussed as cells involved in detoxification, and connective tissue cells as the major storage sites of the labeled material. Excretion in feces and secretion in mucus are thought to be the routes of 14 C elimination .
Towards Safer Subsea Interventions: Report on Using Glass-Free S3D Technology To Improve ROV Tasks (2012)

Abstract Towards Safer Subsea Interventions:Report on Using Glass-Free S3D Technology to Improve ROV Tasks This paper will present the complete journey 'from onshore tests to fielddeployment' to qualify the Kolpi glassfree S3D technology for offshore usage. The Kolpi glass free S3D technology helps operators to conduct precise subseainterventions requiring the use of the manipulator arm and to enable higherperformance and safer execution of ROV tasks. This fits particular well into the recent efforts of the offshore energyindustry to improve precision levels of subsea interventions to adequatelyrespond to the increased risk level and to improve contingency underwater. Tomeet these challenges, it will be crucial for subsea operations to move from aflat representation on today's monitors towards more ergonomic solution such asglass free 3D viewing with depth perception and a more natural and intuitiveinteraction to address the skill shortage and to reduce the learning curve fornew pilots. To respond to these requirements, the new S3D topside solution for ROVoperations was extensivly tested by a consortium co-led by Total, Technip, Saipem, Ifremer and Kolpi in 2010 and followed by two offshore missions in2011, including operational work conducted during a field development in WestAfrica This paper will cover the execution of the qualification tests, the resultsobtained during tests in a controlled environment as well as the feedbackreceived by some of the 87 ROV pilots who tried the system. Furthermore, wewill summarize the findings of the various trials and presenting the how andwhy when selecting the right S3D user interface for safer subseainterventions.
Introducing JMIR AI (2022)

JMIR AI is a new journal with a focus on publishing applied artificial intelligence and machine learning research. This editorial provides an overview of the primary objectives, the focus areas of the journal, and the types of articles that are within scope.
A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma (2017)

ONC201 is an oral, small molecule selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent apoptosis in tumor cells via integrated stress response activation and Akt/ERK inactivation. We performed a Phase II study that enrolled 17 patients with recurrent, bevacizumab-naïve, IDH1/2 WT glioblastoma who received 625mg ONC201 every three weeks. Median OS was 41.6 weeks with OS6 of 71% and OS9 of 53%. Seven of 17 patients are alive. PFS6 was 11.8% with two patients remaining on study who continue to receive ONC201 for >12 months. One of these patients had a durable objective response with a secondary glioblastoma possessing a H3.3 K27M mutation, exhibiting regression by 85% in one lesion and 76% in the second lesion. The second patient who continues to receive ONC201 for >12 months remains disease-free after enrolling on this trial following a re-resection. No drug-related SAEs or treatment discontinuation due to toxicity occurred. Plasma PK at 2 hours post-dose was 2.6 ug/mL, serum prolactin induction was observed as a surrogate marker of target engagement, and DRD2 was expressed in all evaluated archival tumor specimens. In summary, ONC201 is well tolerated and may have single agent activity in recurrent glioblastoma patients.
DNA Alkylating Agents Alleviate Silencing of Class II Transactivator Gene Expression in L1210 Lymphoma Cells (2002)

MHC class II (Ia) Ag expression is inversely correlated with tumorigenicity and directly correlated with immunogenicity in clones of the mouse L1210 lymphoma (1 ). Understanding the mechanisms by which class II Ag expression is regulated in L1210 lymphoma may facilitate the development of immunotherapeutic approaches for the treatment of some types of lymphoma and leukemia. This study demonstrates that the variation in MHC class II Ag expression among clones of L1210 lymphoma is due to differences in the expression of the class II transactivator (CIITA). Analysis of stable hybrids suggests that CIITA expression is repressed by a dominant mechanism in class II-negative L1210 clones. DNA-alkylating agents such as ethyl methanesulfonate and the chemotherapeutic drug melphalan activate CIITA and class II expression in class II negative L1210 cells, and this effect appears to be restricted to transformed cell lines derived from the early stages of B cell ontogeny. Transient transfection assays demonstrated that the CIITA type III promoter is active in class II(-) L1210 cells, despite the fact that the endogenous gene is not expressed, which suggests that these cells have all of the transacting factors necessary for CIITA transcription. An inverse correlation between methylation of the CIITA transcriptional regulatory region and CIITA expression was observed among L1210 clones. Furthermore, 5-azacytidine treatment activated CIITA expression in class II-negative L1210 cells. Collectively, our results suggest that 1) CIITA gene expression is repressed in class II(-) L1210 cells by methylation of the CIITA upstream regulatory region, and 2) treatment with DNA-alkylating agents overcomes methylation-based silencing of the CIITA gene in L1210 cells.
Photooxidation of Linoleic Acid by Ultraviolet Light and Effect of Superoxide Anion Quencher (1979)

Journal Article Photooxidation of Linoleic Acid by Ultraviolet Light and Effect of Superoxide Anion Quencher Get access Shiro Yamashoji, Shiro Yamashoji Faculty of Nutrition, Kobe Gakuin University, Tammi-ku, Kobe Search for other works by this author on: Oxford Academic Google Scholar Hiromi Yoshida, Hiromi Yoshida Faculty of Nutrition, Kobe Gakuin University, Tammi-ku, Kobe Search for other works by this author on: Oxford Academic Google Scholar Goro Kajimoto Goro Kajimoto Faculty of Nutrition, Kobe Gakuin University, Tammi-ku, Kobe Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 43, Issue 6, 1 June 1979, Pages 1249–1254, https://doi.org/10.1080/00021369.1979.10863612 Published: 01 June 1979 Article history Received: 07 December 1978 Published: 01 June 1979
Including Carbon Emissions from Deforestation in the Carbon Footprint of Brazilian Beef (2011)

Effects of land use changes are starting to be included in estimates of life-cycle greenhouse gas (GHG) emissions, so-called carbon footprints (CFs), from food production. Their omission can lead to serious underestimates, particularly for meat. Here we estimate emissions from the conversion of forest to pasture in the Legal Amazon Region (LAR) of Brazil and present a model to distribute the emissions from deforestation over products and time subsequent to the land use change. Expansion of cattle ranching for beef production is a major cause of deforestation in the LAR. The carbon footprint of beef produced on newly deforested land is estimated at more than 700 kg CO(2)-equivalents per kg carcass weight if direct land use emissions are annualized over 20 years. This is orders of magnitude larger than the figure for beef production on established pasture on non-deforested land. While Brazilian beef exports have originated mainly from areas outside the LAR, i.e. from regions not subject to recent deforestation, we argue that increased production for export has been the key driver of the pasture expansion and deforestation in the LAR during the past decade and this should be reflected in the carbon footprint attributed to beef exports. We conclude that carbon footprint standards must include the more extended effects of land use changes to avoid giving misleading information to policy makers, retailers, and consumers.
Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia (2021)

In a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2 weeks after the second dose was significantly lower in the ten patients with myelofibrosis compared to the 32 with essential thrombocythemia (n = 17) and polycythemia vera (n = 15) grouped together, both in terms of neutralizing anti-SARS-CoV-2 IgG titers and seroprotection rates (32.47 AU/mL vs 217.97 AU/mL, p = 0.003 and 60% vs 93.8%, p = 0.021, respectively). Ruxolitinib, which was the ongoing treatment in five patients with myelofibrosis and three with polycythemia vera, may be implicated in reducing vaccine immunogenicity (p = 0.076), though large prospective study is needed to address this issue.
26. Risk of Post–COVID-19 Dyspnea and Interstitial Lung Disease (ILD) in a Real-World Cohort of Patients Hospitalized with COVID-19 in the United States (2021)

Abstract Background While COVID-19 carries substantial morbidity and mortality, the extent of long-term complications remains unclear. Reports suggest that acute lung damage associated with severe COVID-19 can result in chronic respiratory dysfunction. This study: (1) estimated the incidence of dyspnea and ILD after COVID-19 hospitalization, and (2) assessed risk factors for developing dyspnea and ILD in a real-world cohort of patients hospitalized with COVID-19 using US electronic health records (EHR). Methods Patients in the Optum de-identified COVID-19 EHR database who were hospitalized for COVID-19 (lab confirmed or diagnosis code) between February 20 and July 2020 and had at least 6 months of follow-up were eligible for analysis. Dyspnea and ILD were identified using diagnosis codes. The effects of baseline characteristics and hospitalization factors on the risk of incident dyspnea or ILD 3 to 6 months’ post discharge were evaluated. Results Among eligible patients (n=26,339), 1705 (6.5%) had dyspnea and 220 (0.8%) had ILD 3 to 6 months after discharge. Among patients without prior dyspnea or ILD (n=22,613), 110 (0.5%) had incident ILD (Table 1) and 1036 (4.6%) had incident dyspnea (Table 2) 3 to 6 months after discharge. In multivariate analyses, median (IQR) length of stay (LOS; 5.0 [3.0, 9.0] days in patients who did not develop ILD vs 14.5 [6.0, 26.0] days in patients who developed ILD; RR: 1.12, 95% CI: 1.08, 1.15; P=4.34 x 10-10) and age (RR: 1.02, 95% CI: 1.01, 1.03; P=4.63 x 10-3) were significantly associated with ILD. Median (IQR) LOS (5.0 [3.0, 9.0] days in patients who did not develop dyspnea vs 7 [4.0, 14.0] days in patients who developed dyspnea; RR: 1.04, 95% CI: 1.02, 1.06; P=8.52 x 10-4), number of high-risk comorbidities (RR: 1.18, 95% CI: 1.12, 1.24; P=3.85 x 10-9), and obesity (RR: 1.52, 95% CI: 1.25, 1.86; P=2.59 x 10-4) were significantly associated with dyspnea. Table 1. Selected Baseline Risk Factors for Incident ILD Table 2. Selected Baseline Risk Factors for Incident Dyspnea Conclusion In a real-world cohort, 4.6% and 0.5% of patients developed dyspnea and ILD, respectively, after COVID-19 hospitalization. Multivariate analyses suggested that LOS, age, obesity, and comorbidity burden may be risk factors for post-COVID-19 respiratory complications. Limitations included sensitivity of diagnosis codes, availability of labs, and care-seeking bias. Disclosures Kelly Zalocusky, PhD, F. Hoffmann-La Roche Ltd (Shareholder)Genentech, Inc. (Employee) Devika Chawla, PhD MSPH, F. Hoffmann-La Roche Ltd. (Shareholder)Genentech, Inc. (Employee) Margaret Neighbors, PhD, F. Hoffmann-La Roche Ltd (Shareholder)Genentech, Inc. (Employee) Shemra Rizzo, PhD, F. Hoffmann-La Roche Ltd. (Shareholder)Genentech, Inc. (Employee) Larry Tsai, MD, F. Hoffmann-La Roche Ltd (Shareholder)Genentech, Inc. (Employee)