gebhart/patrepeval huggingface dataset:
FMRP Attenuates Activity Dependent Modifications in the Mitochondrial Proteome (2021)

Abstract Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported that homeostatic plasticity induced by activity deprivation is dysregulated in cortical neurons from Fragile X Mental Retardation protein (FMRP) knockout mice [1]. These findings led us to hypothesize that identifying proteins sensitive to activity deprivation and/or FMRP expression could reveal pathways required for or modified by homeostatic plasticity. Here, we report an unbiased quantitative mass spectrometry used to quantify steady-state proteome changes following chronic activity deprivation in wild type and Fmr1 -/y cortical neurons. Proteome hits responsive to both activity deprivation and the Fmr1 -/y genotype were significantly annotated to mitochondria. We found an increased number of mitochondria annotated proteins whose expression was sensitive to activity deprivation in Fmr1 -/y cortical neurons as compared to wild type neurons. These findings support a novel role of FMRP in attenuating mitochondrial proteome modifications induced by activity deprivation.
Nonsense-Mediated mRNA Decay Deficiency Affects the Auxin Response and Shoot Regeneration in Arabidopsis (2019)

Plants generally possess a strong ability to regenerate organs; for example, in tissue culture, shoots can regenerate from callus, a clump of actively proliferating, undifferentiated cells. Processing of pre-mRNA and ribosomal RNAs is important for callus formation and shoot regeneration. However, our knowledge of the roles of RNA quality control via the nonsense-mediated mRNA decay (NMD) pathway in shoot regeneration is limited. Here, we examined the shoot regeneration phenotypes of the low-beta-amylase1 (lba1)/upstream frame shift1-1 (upf1-1) and upf3-1 mutants, in which the core NMD components UPF1 and UPF3 are defective. These mutants formed callus from hypocotyl explants normally, but this callus behaved abnormally during shoot regeneration: the mutant callus generated numerous adventitious root structures instead of adventitious shoots in an auxin-dependent manner. Quantitative RT-PCR and microarray analyses showed that the upf mutations had widespread effects during culture on shoot-induction medium. In particular, the expression patterns of early auxin response genes, including those encoding AUXIN/INDOLE ACETIC ACID (AUX/IAA) family members, were significantly affected in the upf mutants. Also, the upregulation of shoot apical meristem-related transcription factor genes, such as CUP-SHAPED COTYLEDON1 (CUC1) and CUC2, was inhibited in the mutants. Taken together, these results indicate that NMD-mediated transcriptomic regulation modulates the auxin response in plants and thus plays crucial roles in the early stages of shoot regeneration.
Locomotion and palaeoclimate explain the re-evolution of quadrupedal body form inBrachymeleslizards (2020)

Evolutionary reversals, including re-evolution of lost structures, are commonly found in phylogenetic studies. However, we lack an understanding of how these reversals happen mechanistically. A snake-like body form has evolved many times in vertebrates, and occasionally a quadrupedal form has re-evolved, including in <i>Brachymeles</i> lizards. We use body form and locomotion data for species ranging from snake-like to quadrupedal to address how a quadrupedal form could re-evolve. We show that large, quadrupedal species are faster at burying and surface locomotion than snake-like species, indicating a lack of expected performance trade-off between these modes of locomotion. Species with limbs use them while burying, suggesting that limbs are useful for burying in wet, packed substrates. Palaeoclimatological data suggest that <i>Brachymeles</i> originally evolved a snake-like form under a drier climate probably with looser soil in which it was easier to dig. The quadrupedal clade evolved as the climate became humid, where limbs and large size facilitated fossorial locomotion in packed soils.
2D and 3D high frame rate imaging with limited diffraction beams (1997)

A new 2D (two-dimensional) and 3D (three-dimensional) pulse-echo imaging method (Fourier method) has been developed with limited diffraction beams. In this method, a plane wave pulse (broadband) is used to transmit and limited diffraction beams of different parameters are used to receive. Signals received are processed to obtain spatial Fourier transform of object functions and images are constructed with an inverse Fourier transform. Because only one transmission is required to construct images, this method may achieve a high frame rate (up to 3750 frames/s for biological soft tissues at a depth of 200 mm). To demonstrate the efficacy of the method, both 2D C-mode and 3D images have been simulated using conditions that are typical for medical ultrasound. Results show that images of high resolutions (about 6 wavelengths at 200 mm) and low sidelobes (around -60 dB) can be constructed over a large depth of interest (30 to 200 mm) with a 50 mm diameter aperture. Experiments with the new method have also been carried out. 2D B-mode images have been constructed with conventional linear arrays. In the experiment, an ATS 539 tissue-equivalent phantom and two linear arrays were used. The first array had a center frequency of 2.25 MHz, dimension of 18.288 mm/spl times//spl times/12.192 mm, and 48 elements. The second had a center frequency of 2.5 MHz, 38.4 mm/spl times/10 mm in dimension, and 64 elements. Images of different fields of views were constructed from RF data acquired with these arrays using both the new and conventional dynamic focusing (delay-and-sum) methods. Results show that qualities of images constructed are almost identical with the two methods in terms of sidelobes, contrast, and lateral and axial resolutions. Phase aberration has also been assessed for the two methods, and results show that its influence is about the same on both methods. In addition, a practical imaging system to implement the new method is suggested and potential applications of the method are discussed.
Randomized phase 2 study of maintenance pemetrexed (Pem) versus observation (Obs) for patients (pts) with malignant pleural mesothelioma (MPM) without progression after first-line chemotherapy: Cancer and Leukemia Group B (CALGB) 30901 (Alliance). (2019)

8517 Background: Standard front-line chemotherapy for advanced MPM is (Pem and a platinum; optimal treatment duration is unknown. We performed a randomized phase 2 trial (NCT01085630) to determine if continuation of single-agent Pem after 4-6 cycles of Pem-platinum would improve progression-free survival (PFS). Methods: Eligible pts had histologically confirmed unresectable MPM, and performance status (PS) 0-1. Pts with at least stable disease following 4-6 cycles of Pem-platinum were stratified by first-line regimen (cis- or carboplatin) and histology (epithelioid versus other) and randomized 1:1 to Obs or continuation of Pem until progression. The primary endpoint was PFS. We assumed that Obs produced a median (m) PFS of 3 months (mo) and Pem would yield a 100% improvement in mPFS to 6 mo; 60 eligible pts (30 per arm) were to be randomized. Results: 72 pts from 30 sites registered 12/10-6/16. The study closed early due to slow accrual once 53 pts were randomized; 49 eligible pts (22 Obs, 27 Pem) are included in the efficacy analysis. Pt characteristics (Obs/Pem): age: median (range) 70 (39-85)/70 (52-87); male 68%/78%; PS 0 27%/33%; epithelioid histology 77%/70%; first-line cisplatin 27%/26%. A median of 4 cycles of Pem (range 1-33) was delivered; 22% of pts required dose modification. mPFS was 3 mo on Obs and 3.4 mo on Pem (hazard ratio (HR) 0.99; 95% CI: 0.51-1.90; p=0.9733). Median overall survival (mOS) was 11.8 mo for Obs, and 16.3 mo for Pem (HR 0.86; 95% CI 0.44-1.71; p=0.6737). Toxicities ≥ grade 3 on Pem included anemia 8%, lymphopenia 8%, neutropenia 4%, and fatigue 4%; there were no grade 5 toxicities. A higher baseline level of serum mesothelin related peptide (SMRP) was associated with worse PFS (HR 1.861, p=0.049). Baseline osteopontin did not significantly affect PFS (p=0.3630). Conclusions: Although it was well tolerated, maintenance Pem following initial Pem/platinum doublet chemotherapy does not improve PFS in MPM patients. High baseline SMRP was associated with shorter PFS. Support: U10CA180821, U10CA180882; https://acknowledgments.alliancefound.org . Clinical trial information: NCT01085630.
Effects of avitinib on the pharmacokinetics of osimertinib in vitro and in vivo in rats (2020)

For the first time, we systematically investigated the effect of avitinib, one newly developed third-generation EGFR-TKI, on the pharmacokinetics of osimertinib both in vitro and in vivo using a rat model.
Search for three-jet resonances in pp collisions at square root(s)=7TeV. (2011)

A search for three-jet hadronic resonance production in pp collisions at a center-of-mass energy of 7 TeV has been conducted by the CMS Collaboration at the LHC, using a data sample corresponding to an integrated luminosity of 35 pb(-1). Events with high jet multiplicity and a large scalar sum of jet transverse momenta are analyzed using a signature-based approach. The number of expected standard model background events is found to be in good agreement with the observed events. Limits on the cross section times branching ratio are set in a model of gluino pair production with an R-parity-violating decay to three quarks, and the data rule out such particles within the mass range of 200 to 280 GeV/c2.
Thick-Film Ceramic Strain Sensors for Structural Health Monitoring (2011)

Structural Health Monitoring represents one of the primary field applications for new sensor technologies. Different kinds of sensors to monitor stability anomalies of civil structures are deployed on different kinds of building materials. Observation of stability must be durable and reliable for the lifetime of a structure. This paper is part of a research to investigate the possibility of application of thick-film (TF) piezoresistive sensors on building materials for the scope of monitoring structure's stability and conditions of load. As a first approach toward this objective, TF piezoresistive sensors will be used like metal-foil strain gauges on two different building materials, namely brick (clay) and concrete. A boosted Wheatstone bridge interface circuitry will be proposed and simulated with a Saber simulator. Thick film ceramic sensors (TFCS) will be applied on red brick and concrete to investigate TF response proportionality and linearity when applied on these two kinds of building materials.
A Primary Sequence Analysis of the ARGONAUTE Protein Family in Plants (2016)

Small RNA (sRNA)-mediated gene silencing represents a conserved regulatory mechanism controlling a wide diversity of developmental processes through interactions of sRNAs with proteins of the ARGONAUTE (AGO) family. On the basis of a large phylogenetic analysis that includes 206 AGO genes belonging to 23 plant species, AGO genes group into four clades corresponding to the phylogenetic distribution proposed for the ten family members of Arabidopsis thaliana. A primary analysis of the corresponding protein sequences resulted in 50 sequences of amino acids (blocks) conserved across their linear length. Protein members of the AGO4/6/8/9 and AGO1/10 clades are more conserved than members of the AGO5 and AGO2/3/7 clades. In addition to blocks containing components of the PIWI, PAZ, and DUF1785 domains, members of the AGO2/3/7 and AGO4/6/8/9 clades possess other consensus block sequences that are exclusive of members within these clades, suggesting unforeseen functional specialization revealed by their primary sequence. We also show that AGO proteins of animal and plant kingdoms share linear sequences of blocks that include motifs involved in posttranslational modifications such as those regulating AGO2 in humans and the PIWI protein AUBERGINE in Drosophila. Our results open possibilities for exploring new structural and functional aspects related to the evolution of AGO proteins within the plant kingdom, and their convergence with analogous proteins in mammals and invertebrates.
Optical applications of laser-induced gratings in Eu doped glasses (1990)

Laser-induced changes in the refractive index are used to create superimposed transient population gratings and permanent structural gratings in Eu(3+) doped silicate and phosphate glasses. Potential uses for these laser-induced gratings (LIGs) are investigated. First, the structural gratings are shown to be permanent at room temperature and their use as a holographic storage medium is discussed. Second, a permanent LIG of this type is used to demultiplex multifrequency laser beams, demonstrating its use as a tunable line filter. Third, the transient LIG is used to modulate the amplitude of a laser beam which is passed through the sample and scatters off the permanent LIG. This results in information being transferred from one beam to another beam. It was found that thermal lensing plays an important role in the formation of this type of permanent LIG and a procedure for determining the tilt angle of the fringes of the LIG is discussed.
Synthesis of NiO Crystals Exposing Stable High‐Index Facets (2020)

Metal oxides exposing high-index facets are potentially impactful in catalysis and adsorption processes owing to under-coordinated ions and polarities that alter their interfacial properties compared to low-index facets. Here, we report molten-salt syntheses of NiO particles exposing a variety of crystal facets. We show that for a given anion (nitrate or chloride), the alkali cation has a notable impact on the formation of crystals exposing {311}, {611}, {100}, and {111} faces. Based on a parametric analysis of synthesis conditions, we postulate that the crystallization mechanism is governed by the formation of growth units consisting of Ni<sup>II</sup> complexes whose coordination numbers are determined by temperature and the selection of anion (associated to the coordination sphere) and alkali cation (associated with the outer coordination sphere). Notably, our findings reveal that high-index facets are particularly favored in chloride media and are stable under prolonged periods of catalysis and steaming.
Fever After Zoledronic Acid Administration Is Due to Increase in TNF- α and IL-6 (2003)

The most common adverse event typically associated with bisphosphonate therapy is transient fever. The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. Eighteen consecutive cancer patients with bone metastases were treated, for the first time, with a single dose of 4 mg zoledronic acid infusion. They were prospectively evaluated for circulating TNF-alpha, interferon-gamma (IFN-gamma), and IL-6 levels at different times, just before and 1, 2, 7, and 21 days after diphosphonate infusion. Clinical and standard laboratory parameters were recorded at the same time points. TNF-alpha circulating levels increased significantly 1 and 2 days after zoledronic acid infusion (respectively, p = 0.002 and p < 0.001) and then decreased to levels similar to the basal levels. IL-6 levels increased significantly 1 day after the infusion (p = 0.007), returning to values similar to the median basal values 2 days after zoledronic acid administration. Moreover, in patients who experienced fever, the TNF-alpha and IL-6 increases were higher than in patients without fever. No statistically significant differences in IFN-gamma were identified at different time points in patients with and without fever. Our results show that zoledronic acid induces transient TNF-alpha and IL-6 increases and that these increases are higher in patients who have developed fever, suggesting that these cytokines could be responsible for fever pathogenesis. The sharp reduction in serum calcium levels observed in patients with fever may be related to zoledronic acid pharmacokinetic modifications.
A review of the internal short circuit mechanism in lithium‐ion batteries: Inducement, detection and prevention (2021)

Internal short circuit (ISC) of lithium-ion battery is one of the most common reasons for thermal runaway, commonly caused by mechanical abuse, electrical abuse and thermal abuse. This study comprehensively summarizes the inducement, detection and prevention of the ISC. Firstly, the fault tree is utilized to analyze the ISC inducement, including the abuse conditions, improper manufacture and design defects. Secondly, the ISC substitute triggering methods (utilizing mechanical deformation from the outside or utilizing controllable components introduced inside) are summarized considering the randomness of ISC, which have high repeatability. Moreover, these methods can be used to investigate the evolution and the hazard boundary of ISC. The ISC severity is determined by the ISC type, ISC location, ISC area, battery state of charge, capacity, material and structure. There are four types of ISC mode, the danger extends ranking is aluminum-anode > aluminum-copper > cathode-copper > cathode-anode. The ISC evolution is presented based on the upper summary. Then, the ISC detection methods are reviewed: (1) comparing the measured data with the predicted value from the model; (2) detecting whether the battery has self-discharge; (3) comparing based on the battery inconsistency and (4) other signals. Finally, the prevention strategies are summarized, which can be used to reduce the ISC risk by blocking electron or lithium-ion channels in the battery cell.
SMALL REVIEW (2010)

Nosocomial Bacteriuria in the Dog Elevated Alkaline Phosphatase (ALP) in Scottish Terriers
Using a Ground-Based SAR Interferometer and a Terrestrial Laser Scanner to Monitor a Snow-Covered Slope: Results From an Experimental Data Collection in Tyrol (Austria) (2009)

In this paper, we report on an experimental activity aimed at investigating the potential of two terrestrial remote-sensing techniques, namely, ground-based SAR (GB SAR) interferometry and terrestrial laser scanning, in order to retrieve snow-depth (SD) measurements in mountainous regions. Terrestrial laser scanning is a more consolidated technique based on the measurement of the optical (near infrared) reflectivity, and it is affected by the surface of the snow layer: a temporal data sequence allows us to estimate the absolute SD variation. Recent use of SAR interferometry to evaluate snow-mass characteristics is based on relating the measured interferometric phase shift to a change in the snow mass. Interferometric GB SAR measurements and terrestrial laser scanner scans were collected together with pointwise conventional measurements of physical snow parameters during the winters of 2005/2006 and 2006/2007. The experiment was carried out in the Wattener Lizum, a high Alpine area at about 2000-m elevation north of the main ridge of the Austrian Alps in Tyrol. Notwithstanding the difficulty of providing both lengthy data record in dry snow conditions and detailed knowledge of the observed snow characteristics, the obtained results confirmed the presence of a clearly measurable interferometric phase variation in relation to the growing height of the snow layer. A comparison of the SD maps obtained through the two techniques shows differences partly due to the different nature of the two observations.
Multi-ordered short-range mover prediction models for tracking and avoidance (2012)

This paper introduces a framework and methods that can be used to predict the movements of intelligent moving bodies in the presence of perceived static and dynamic environmental stimulus, such as terrain and weather influences. These methods are especially important for Intelligent-Autonomous Mobile (I-AM) Systems, where they can improve upon contemporary methods for tracking and avoidance by allowing I-AM systems to act or react based on enhanced predictions. These methods can also complement Cooperative Behavior Control (CBC) strategies of distributed, multi-agent systems wherein cooperation can be in the form of prediction rather than direct communication. Probability spatial distributions for intelligent moving objects, with respect to First-Order, Second-Order, and Third-Order predictions, have been formulated. This is a novel method since most prediction approaches use Kalman Filters to estimate future states based solely on previously observed states. Most prediction models do not take into consideration mobility characteristics (e.g., Ackermann Steering), nor the probable decision making capabilities of intelligent entities. By adding higher levels of fidelity to prediction models, more accurate and precise object tracking, and obstacle avoidance and/or engagement can be accomplished with already proven techniques.
Feline Rhinotracheitis-Calici-Panleukopenia Vaccine (1978)

With reference to Dr. Turner's letter on feline rhinotracheitis-calici-panleukopenia vaccine (Pediatrics 61:675, April 1978) and his concern for its potential infection in man, I believe he has overreacted to the coincidental occurrence of herpetic-type dermatitis in children from two households in which cats had received FVR C-P vaccination. It has been shown that the virus of feline viral rhinotracheitis is a herpesvirus, but is highly specific for the feline species. Numerous attempts have been made to propagate the virus in the tissues of other animals, including man, without success.
Impact of Underwater Laser Annealing on Polycrystalline Silicon Thin-Film Transistor for Inactivation of Electrical Defects at Super Low Temperature (2013)

We propose underwater laser annealing (WLA) for the inactivation of electrical defects in polycrystalline silicon thin-film transistors (poly-Si TFTs) at super low-temperature. This technique can reduce the temperature of inactivation process drastically, and it requires only UV laser and deionized water. We performed WLA after the fabrication of top-gate type poly-Si TFTs. After WLA, the field-effect mobility of poly-Si TFTs increased from 52 to 72 cm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{2}/{\hbox{V}}\cdot{\hbox{sec}}$</tex> </formula> . The TFT surface was exposed to water vapor which was generated by laser irradiation, resulting that electrical defects were inactivated by active species in water vapor.