gebhart/patrepeval huggingface dataset:
Selection for Electron Microscopy of Specific Areas in Large Epoxy Tissue Sections (1965)

Tissue blocks 2 × 2 × 0.4 cm were fixed 6-24 hr in phosphate-buffered 6% glutaraldehyde then sliced to 2 × 2 × 0.1 cm and rinsed in phosphate buffer for at least 12 hr. Fixation was continued for 2 hr in phosphate-buffered 1-2% OsO4. The slices were dehydrated, infiltrated with Araldite, and embedded in flat-bottomed plastic molds. Sectioning at 4-8 μ with a sliding microtome was facilitated by addition of 10% dibutylphalate to the standard epoxy mixture. The sections were spread on water and attached to coverslips by drying, then heating to 80 C for 1 min. Staining 2 min with 1-3% KMnO4 and temporary mounting in glycerol on a slide allowed the desired area for electron microscopy to be selected and marked. This area was then cemented to the facet of a conventional epoxy casting with a drop of epoxy resin (without added dibutylphthalate). After polymerization, the coverslip was removed by quick cooling leaving a flat re-embedded portion of the original section. This portion was viewed by transillumination in a dissecting microscope and trimmed of surplus tissue. Ultrathin sections for electron microscopy were obtained in the usual manner.
Refined radial basis function-generated finite difference analysis of non-Newtonian natural convection (2022)

Code and data for https://doi.org/10.1063/5.0257896 published in Physics of Fluids 37, 033130 (2025) Refined radial basis function-generated finite difference analysis of non-Newtonian natural convection In this paper, we present a refined radial basis function-generated finite difference solution for a non-Newtonian fluid in a closed differentially heated cavity. The non-Newtonian behavior is modeled with the Ostwald–de Waele power law and the buoyancy with the Boussinesq approximation. The problem domain is discretized with scattered nodes without any requirement for a topological relation between them. This allows a trivial generalization of the solution procedure to complex irregular three dimensional (3D) domains, which is also demonstrated by solving the problem in a two dimensional (2D) and 3D geometry mimicking a porous filter. The results in 2D are compared with two reference solutions that use the finite volume method in a conjunction with two different stabilization techniques, where we achieved good agreement with the reference data. The refinement is implemented on top of a dedicated meshless node positioning algorithm using piecewise linear node density function that ensures sufficient node density in the center of the domain while maximizing the node density in a boundary layer where the most intense dynamic is expected. The results show that with a refined approach, more than five times fewer nodes are required to obtain the results with the same accuracy compared to the regular discretization. The paper also discusses the convergence with refined discretization for different scenarios for up to 2e5 nodes, the impact of method parameters, the behavior of the flow in the boundary layer, the behavior of the viscosity, and the geometric flexibility of the proposed solution procedure.
A proactive scheme for securing ID/locator split architecture (2012)

The ID/locator split-based approach has been widely recognized as a promising approach for the design of future networks. However, the existing ID/locator split architectures are still vulnerable to various attacks, such as impersonation attacks and man-in-the-middle attacks. They cannot be simply protected by the existing security mechanisms, which have the limitations especially on scalability. To solve these problems, we propose a proactive scheme for securing ID/locator split architecture, which embeds built-in security features to enable proactive protections of the architecture. Through this scheme, hosts register their information to the network securely, obtain trustworthy information of destination hosts, authenticate each other, and securely update their locators without requiring an involvement of a trusted third party (TTP). Compared to other existing security mechanisms, the proposed scheme does not require additional authentication mechanism and it can provide the thorough protections of the whole architecture.
Molecular orbital energy level modulation through incorporation of selenium and fluorine into conjugated polymers for organic photovoltaic cells (2013)

We demonstrated an effective chemical approach to modulate the energy levels of conjugated polymers by synergistically combining fluorine substitution and thiophene–selenophene exchange. Such modifications from TQ1 resulted in a significantly enhanced open-circuit voltage up to 1.0 V while retaining high photovoltaic performance.
Memory Bandage for Functional Compression Management for Venous Ulcers (2016)

In current compression practice for the treatment of chronic venous disorders, there has always been a challenge of controlled compression by a bandage to achieve a particular pressure range in the affected region of the limb. The challenges in compression in the products could be solved if there were the possibility of stress control in fabric. Herein, we are exploiting the newly discovered phenomena, i.e., stress memory, in a memory polymer (MP) for the design and investigation of a smart bandage for functional compression benefits. A memory bandage is developed using a blend yarn consisting of MP filaments (segmented polyurethane) and nylon filaments. Results showed the possibility to control or manage the internal stress developed in the bandage in wrapped position by simple heating, and thus allowing pressure readjustment externally. Extra pressure generated by the bandage increases with increasing the level of temperature and strain (p &lt; 0.05). The pressure variations also depend on the number of layers and limb circumference (p &lt; 0.05). The memory bandage could have a great potential over existing conventional compression products, as they could give more freedom to govern pressure level whenever needed during the course of compression therapy as a novel wound care management system.
Subpicosecond solitons in an actively mode-locked fiber laser (1996)

Experimental results are presented for a study of the stability regime of an actively mode-locked polarizationmaintaining fiber ring laser used as a memory. Observations indicate that the pulse widths in the memory can be reduced (by soliton effects) by a factor of approximately 4.4 below the pulse widths predicted by standard active mode-locking theory. Stability regions for the solitons are mapped and compared with theoretical predictions.
Dual-gate (FinFet) and tri-gate MOSFETs: simulation and design (2004)

The continued downward scaling of silicon MOSFET device dimensions below one tenth micron has presented new and serious challenges for future integrated circuit applications. Accordingly, new MOSFET structures, such as the dual-gate (FinFET) and the tri-Gate transistor, have been proposed to replace the conventional planar MOSFET. These devices are compatible with conventional silicon integrated circuit processing, but offer superior performance as the device is scaled into the nanometer range. However, the physics of the MOSFET's operation in these new device structures is somewhat different. This study aims to investigate the differences in performance of these two devices and their device design using a commercial, three-dimensional numerical simulator ATLAS from Silvaco International.
Protocol for production of matrix-matched brain tissue standards for imaging by laser ablation-inductively coupled plasma-mass spectrometry (2013)

Calibration with matrix-matched standards remains the most practical means for producing quantitative images of trace metal distribution in tissue sections by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). A general guide for producing matrix-matched standards for assay of trace metals in brain tissue is presented. Cortical tissue was taken from pooled sheep brains and spiked with varying approximate concentrations of standard solutions of Co, Cu, Fe, Mg, Mn, Sr, Se and Zn. The tissue was homogenised and the total analyte amount accurately determined by solution nebulisation ICP-MS. The analytical figures of merit for LA-ICP-MS imaging were determined from these tissue standards cryosectioned at 30 μm. Repeated 8-point calibration curves were reproducibly linear, with correlation coefficients ranging from 0.9874 (Mg) to 0.9991 (Sr). Limits of analysis were suitable for quantifying most analytes in a sample mouse brain, with the exception of Co and Se.
Advanced High-Strength Steel and Carbon Fiber Reinforced Polymer Composite Body in White for Passenger Cars: Environmental Performance and Sustainable Return on Investment under Different Propulsion Modes (2019)

Vehicle lightweighting strategies must deliver sustainable returns to customers and society. This work evaluates the sustainable return on investment (SROI) of lightweighted advanced high strength steel (AHSS) and carbon fiber reinforced polymer (CFRP)-intensive multimaterial bodies in white (BIWs) for automobiles. The SROI depends on the lightweighted BIW’s manufacturing cost and the difference in sustainable cost between a baseline (mild steel) BIW and the lightweighted alternative. The sustainable cost is the sum of the customer’s lifetime fuel (or electricity) costs and the costs of environmental externalities. A cradle-to-grave life cycle assessment (LCA) was conducted to quantify the environmental impacts of CFRP and AHSS BIWs in gasoline-fueled cars, bioethanol (E85)-fueled cars, and battery electric vehicles (BEVs) driven for a lifetime distance of 200 000 km. For cars fueled with gasoline- or corn-based bioethanol, the CFRP BIW yielded the lowest SROI; the AHSS BIW performed best for BEVs and cars fueled with wood bioethanol. However, the commercial availability of recycled carbon fiber should increase the SROI of the CFRP BIW in the future. Additionally, the SROI of CFRP BIWs is maximized when carbon fiber production is done using energy from a low carbon-intensity electric grid or decentralized sources such as waste-to-energy incineration plants.
La veinopathie portale oblitérante, une maladie hépatique émergente chez les patients infectés par le VIH (2009)

Depuis l’avenement des tritherapies antiretrovirales, les patients infectes par le virus de l’immunodeficience humaine (VIH) ne meurent plus du VIH mais de maladies associees demasquees par l’allongement de la duree de vie des patients. Les maladies du foie, frequentes chez les patients VIH pour des raisons epidemiologiques, se classent aujourd’hui parmi les trois premieres causes de deces non liees au sida des patients VIH immunorestaures avec les cancers et les pathologies cardiovasculaires. Les infections virales hepatotropes ainsi que la steatohepatite (alcoolique et non alcoolique) sont les maladies hepatiques les plus frequentes chez ce type de patients. D’autres maladies hepatiques, dont le(s) mecanisme(s) physiopathologique(s) est (sont) encore imparfaitement compris, ont ete recemment decrites chez des patients ayant une infection ancienne par le VIH (> 15 ans). Une atteinte de la microvascularisation hepatique, se traduisant par des lesions histologiques comme l’hyperplasie nodulaire regenerative, la sclerose hepatoportale, la dilatation sinusoidale, explique certaines de ces hepatopathies. L’origine de ces vasculopathies hepatiques pourrait, au moins pour certains cas, etre un etat prothrombotique lie a une deregulation immunitaire persistante en depit de la restauration immune. La prise au long cours des antiviraux pourrait egalement participer a la genese de ce type de lesions. Nous detaillons dans cette revue ces maladies vasculaires du foie associees a l’infection par le VIH que nous avons propose de denommer « veinopathies portales obliterantes associees au VIH » ou HIVOP (HIV-associated obstructive portopathy).
All-optical magnetic recording and its thermal issues (2010)

This work presents a thermal analysis that explains experimental observation in all-optical magnetic recording (AOMR). An integrated model is used to describe thermal processes at different time scales in AOMR. The formation of magnetic marks is discussed and implemented by developing a simulator based on 3-dimensional finite element method (FEM). The simulator is able to carry out thermal analysis of the thin film media and is a useful tool for design of AOMR media structure, especially for the thermal sink layer.
The Estimation of Water Injection Profiles From Temperature Surveys (1953)

Abstract The heat flow processes determining the injection and shut-in temperaturelogs in a water injection well have been analyzed and the theoretical basis fordetermining the water injectivity profiles from the temperature logs has beenpresented. Both the injection and the subsequent shut-in logs are necessary toresolve the injection interval into relative water intake strata; the former, to provide an accurate estimation of the thicknesses of the strata, and the latter to indicate themajor and minor intake rates into the strata. A procedure is described forestimating the injectivity profile from the temperature logs and is applied toseveral temperature logs. For a water injection well, a comparison is made ofthe injectivity profiles obtained from the core analysis, the spinner survey, and the temperature logs. Introduction In secondary recovery of oil by water flooding, the injectivity profile isneeded to obtain diagnostic evaluation of water intake distribution over theinjection interval. If the distribution is unfavorable among the variousstrata, corrective measures can be taken to provide better control. Numerous methods have been developed for determining the injectivity profilefrom water velocity measurements in well bores. Often, dependence is placedupon core analyses and/or electric logs for estimating the relative waterintakes over the injection interval. In many cases, the temperature log methoddescribed herein will give results more diagnostic than those obtained throughuse of the other available methods inasmuch as it is based upon the study oftemperature disturbances in and around the well bore as a function of waterflow in the well bore and in the formation. This method is the result of analyses of a number of temperature surveysmade in water injection wells to determine the point of entry of the water intothe formation. The material in this paper is presented in two sections: thefirst deals with the theoretical study of temperature survey data, and thesecond deals with the field application. T.P. 3637
PRINCIPLES AND FABRICATION PROCESS OF THE ACTUATOR (1997)

SUMMARY We present a two-dimensional micro conveyer which utilizes electromagnetic force. The micro conveyer comprises of a twolayer planar coil array 4Omz in size for the stator and a permanent magnet for the mover. This paper describes the design principle, calculation of thrust , fabrication process of the planar coil array and conveyance properties of the fabricated micro conveyer. The maximum conveyance mass of 1.2g were obtained with the applied current of 1AIphase and the maximum conveyaince speed was 30mm/sec without a conveyance object when the NdFeB magnet 5 X 5 X lmm3 in size magnetized in the verti
Chelation in metal intoxication. XLIV: Efficacy of alpha-mercapto-beta-(5-substituted, 2-furyl) acrylic acids in mobilizing intracellularly bound cadmium in rat. (2000)

The efficacy of alpha-mercapto-beta-(2-furyl) acrylic acid (MFA), alpha-mercapto-beta-(5-sodiumsulfonate, 2-furyl) acrylic acid (MSFA) and alpha-mercapto-beta-(5-acetoxymethyl, 2-furyl) acrylic acid (MAFA) to mobilize intracellularly bound cadmium in liver and kidney was investigated in rats pre-exposed to cadmium. MFA was effective in reducing cadmium levels of hepatic and renal supernatant cytosolic fraction (SCF) while MSFA and MAFA were effective in lowering cadmium levels of renal SCF and hepatic SCF respectively. All the chelating agents also enhanced the excretion of cadmium more in feces than in urine. However, substitution on the furan ring lowered cadmium mobilizing efficacy of the parent compound, MFA. The treatment with MFA did not affect the status of endogenous zinc and copper while the treatment with MSFA and MAFA enhanced their excretion. MSFA increased hepatic and renal zinc and renal copper while MAFA increased their copper levels.
Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial (2019)

ClinicalTrials.gov NCT01806259.
Collaborative, integrated software development with multiple views (1994)

This paper presents a new model for supporting collaborative, integrated software development utilising multiple textual and graphical views. Views can be asynchronously edited by different developers using separate versions. Versions can be incrementally merged, with merge conflicts detected and presented. Synchronous editing of views by different developers is also supported. View updates are broadcast to other users and are incrementally incorporated as required in their alternative versions. The new model is illustrated by its use in a software development environment for an object-oriented language.
Selective synthesis of N-protected exo-spiro[oxirane-3,2′-tropanes] (2019)

<italic>N</italic>-Cbz- and <italic>N</italic>-Boc-protected <italic>exo</italic>-spiro[oxirane-3,2′-tropanes] were selectively synthesized <italic>via</italic> either epoxidation or hydroxybromination/dehydrobromination of the corresponding alkenes.
Antimicrobial activity of lemongrass oil against Salmonella enterica on organic leafy greens (2011)

This study demonstrates the potential of lemongrass oil solutions to inactivate Salm. Newport on organic leafy greens.
Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro (2023)

The presence of inflammatory mediators in the tumor microenvironment, such as cytokines, growth factors or eicosanoids, indicate cancer-related inflammatory processes. Targeting these inflammatory mediators and related signal pathways may offer a rational strategy for the treatment of cancer. This study focuses on the incorporation of metabolically stable, sterically demanding, and hydrophobic dicarba-closo-dodecaboranes (carboranes) into dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors that are key enzymes in the biosynthesis of eicosanoids. The di-tert-butylphenol derivative tebufelone represents a selective dual COX-2/5-LO inhibitor. The incorporation of meta- or para-carborane into the tebufelone scaffold resulted in eight carborane-based tebufelone analogs that show no COX inhibition but 5-LO inhibitory activity in vitro. Cell viability studies on HT29 colon adenocarcinoma cells revealed that the observed antiproliferative effect of the para-carborane analogs of tebufelone is enhanced by structural modifications that include chain elongation in combination with introduction of a methylene spacer resulting in higher anticancer activity compared to tebufelone. Hence, this strategy proved to be a promising approach to design potent 5-LO inhibitors with potential application as cytostatic agents.
A time-domain method for the accurate characterization of linear systems (2002)

The characterization of a linear system from input/output measurements is addressed. The use of wideband test waveforms and of a fast time-domain constrained-least-squares algorithm is described. The accuracy of the method is analyzed, and possible applications are outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expanding Attentional Capacity with Adaptive Training on a Multiple Object Tracking Task (2011)

One frequently used task for measuring attentional capacity is multiple object tracking (MOT), where observers attentively track multiple moving target items among a set of identical distractors. MOT performance depends on both the number of targets and their speed (Alvarez & Franconeri, 2007), and therefore provides two measures of attentional capacity: (1) the number of items that can be tracked at a fixed speed, (2) the maximum speed at which a fixed number of items can be tracked. Previously, we showed that 10 days of adaptive MOT training increased performance on both of these measures. Here, we replicate these results, then extend them with the inclusion of (1) an active control group, (2) pre-training and post-training structural and functional neuroimaging measures, and (3) an extensive battery of normed “transfer” tasks, to determine whether improvement in visual attention affects other cognitive domains. Initially, a threshold procedure was used to determine the speed at which subjects could track four targets among twelve distractors. Subjects then completed twenty sessions of MOT practice (90 trials per day), with the object speed on each trial adaptively updated based on the current trial's performance. Over twenty sessions of training, eight subjects increased the speed at which they could reliably track four objects from an initial average of 5.5 deg/s to a final speed of 13.1 deg/s. Additionally, all subjects were able to track additional targets when tested at their initial pre-training speed. In contrast, subjects assigned to the “active control” condition (an adaptive n-back task) did not significantly improve on these MOT metrics. These findings confirm that it is possible to dramatically increase the capacity of visual attention through training, and that training one measure of capacity (increased tracking speed) transfers improvements to a second measure of capacity (increased number of targets).
A frameless stereotactic approach to neurosurgical planning based on retrospective patient-image registration (1993)

A frameless stereotactic device interfacing an electromagnetic three-dimensional (3-D) digitizer to a computer workstation is described. The patient-image coordinate transformation was found by retrospectively registering a digitizer-derived model of the patient's scalp with a magnetic resonance (MR) imaging-derived model of the same surface. This procedure was performed with routine imaging data, eliminating the need to obtain special-purpose MR images with fiducial markers in place. After patient-image fusion was achieved, a hand-held digitizing stylus was moved over the scalp and tracked in real time on cross-sectional and 3-D brain images on the computer screen. This device was used for presurgical localization of lesions in 10 patients with meningeal and superficial brain tumors. The results suggest that the system is accurate enough (typical error range 3 to 8 mm) to enable the surgeon to reduce the craniotomy to one-half the size advisable with conventional qualitative presurgical planning.
POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins (2004)

http://polyview.cchmc.org.
Pulmonary solid tumor with coexisting pulmonary aspergillosis: case reports and literature review (2015)

Clinicians should be alert to underlying malignant disease if airway Aspergillus infection is suspicious in a patient without strong risk factors for invasive fungal disease. On the other hand, when lung cancer is coexisting with airway necrotizing Aspergillosis, clinicians should properly manage these two diseases simultaneously.
Selepressin in Septic Shock (2015)

Asfar, Pierre MD, PhD; Russell, James A. MD, PhD; Tuckermann, Jan PhD; Radermacher, Peter MD, PhD Author Information