gebhart/patrepeval huggingface dataset:
Catalysis in organosilicon chemistry. IV. Proton inventory of the transition state for hydride expulsion from silicon (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis in organosilicon chemistry. IV. Proton inventory of the transition state for hydride expulsion from siliconClinton R. Howie, J. K. Lee, and R. L. SchowenCite this: J. Am. Chem. Soc. 1973, 95, 16, 5286–5288Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://doi.org/10.1021/ja00797a032RIGHTS & PERMISSIONSArticle Views87Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (376 KB) Get e-Alerts Get e-Alerts
Perspectives on this Article from Basal Cell Carcinoma Chemoprevention with Nonsteroidal Anti-inflammatory Drugs in Genetically Predisposed <i>PTCH1</i><sup>+/−</sup> Humans and Mice (2023)

Perspectives on this Article from Basal Cell Carcinoma Chemoprevention with Nonsteroidal Anti-inflammatory Drugs in Genetically Predisposed &lt;i&gt;PTCH1&lt;/i&gt;&lt;sup&gt;+/−&lt;/sup&gt; Humans and Mice
Synthesis of 2-(((4-fluoroalkoxy-2-pyridyl)methyl)sulfinyl)-1H-benzimidazoles as antiulcer agents. (1990)

Many 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles were synthesized and tested for anti-secretory, antiulcer, and cytoprotective activities. Most of these compounds were superior to omeprazole in anti-secretory and antiulcer potencies, and especially in protecting the gastric mucosa from ethanol-induced damage. Among these compounds, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl] - 1H-benzimidazole, AG-1749 (lansoprazole) (6f), was selected for further development and clinical evaluation.
Orientation-dependent Influence of an Intergenic Enhancer on the Promoter Activity of the Divergently Transcribed Mouse Shsp/αB-crystallin andMkbp/HspB2 Genes (2002)

The mouse Shsp/alphaB-crystallin and Mkbp/HspB2 genes are closely linked and divergently transcribed. In this study, we have analyzed the contribution of the intergenic enhancer to Shsp/alphaB-crystallin and Mkbp/HspB2 promoter activity using dual-reporter vectors in transient transfection and transgenic mouse experiments. Deletion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 30- and 93-fold and Mkbp/HspB2 promoter activity by 6- and 10-fold in transiently transfected mouse lens alpha-TN4 and myoblast C2C12 cells, respectively. Surprisingly, inversion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 17-fold, but did not affect Mkbp/HspB2 promoter activity in the transfected cells. In contrast, enhancer activity was orientation-independent in combination with a heterologous promoter in transfected cells. Transgenic mouse experiments established the orientation dependence and Shsp/alphaB-crystallin promoter preference of the intergenic enhancer in its native context. The orientation dependence and preferential effect of the Shsp/alphaB-crystallin enhancer on the Shsp/alphaB-crystallin promoter provide an example of adaptive changes in gene regulation accompanying the functional diversification of duplicated genes during evolution.
Affinity precipitation of a monoclonal antibody from an industrial harvest feedstock using an ELP‐Z stimuli responsive biopolymer (2014)

In this work, a proof of concept elastin-like polypeptide-Z domain fusion (ELP-Z) based affinity precipitation process is developed for monoclonal antibody (mAb) purification from industrial harvest feeds. Greater than 99% mAb recoveries are obtained during the initial binding step of the process for both pure mAb and the mAb harvest feeds. Great than 90% overall mAb yields are also obtained for the subsequent elution step of the process with no measurable mAb aggregation. The process is shown to result in more than 2 logs of host cell protein (HCP) and more than 4 logs of DNA clearance from the harvest feed. While the overall mAb yield and HCP clearance for the affinity precipitation process was comparable to Protein A chromatography the DNA clearance was clearly superior. Performance is maintained for mAb final elution concentrations up to 20 g/L, demonstrating the ability of the process to both concentrate and purify the mAb. Effective ELP-Z regeneration is also demonstrated using 0.1 M NaOH with no adverse effect on subsequent capture efficiency. Finally, the reusability of the ELP-Z construct and robustness of the process is demonstrated for up to three purification-regeneration cycles with minimal product and impurity carryover and high yields and purity. This work demonstrates that the ELP-Z based precipitation approach can be successfully employed as an affinity capture step for industrial mAbs.
BIOTINIDASE DEFICIENCY AND JUVENILE MYELOMONOCYTIC LEUKEMIA IN A TURKISH INFANT OF CONSANGUINEOUS PARENTS (2007)

Here, a case is presented with two rare genetic disorders, biotinidase deficiency and juvenile myelomonocytic leukemia, in a Turkish infant. This case may serve as a reminder that the diagnosis of a genetic disorder does not exclude the possibility of a second congenital but acquired disease.
Carboplatin dosing in the treatment of epithelial ovarian cancer (EOC): A Gynecologic Oncology Group (GOG) study. (2012)

5041 Background: Optimal carboplatin dosing (CPRx) for patients (pts) with renal dysfunction or low creatinine (Cr) values in the setting of malnutrition and ascites is unknown. Multiple methods have been utilized to estimate Cr clearance (CrCl) but these perform differently in pts with abnormal Cr values. We sought to determine 1) the relationship between adverse events (AE) and baseline CrCl used for CPRx; 2) the effect on CPRx of using Cockcroft-Gault (CG) +/- the NCI/CTEP recommended limits (CGL), Modification of diet in renal disease (MDRD) or Jelliffe Formula (J) renal function estimates. Methods: Retrospective data were drawn from pts treated on GOG 182, a phase III trial of carboplatin doublet vs triplet or sequential doublet combinations in stage III/IV EOC. For patient safety, the protocol was amended to assign the lower limit of Cr at 0.6mg/dl for CPRx. Area under the receiver operating characteristic curve (AUC) was used to describe associations between CrCl J and various AE. Sensitivity and positive predictive values (PPV) described the AE rate in pts with CrCl J &lt;60ml/min. CPRx for each pt was calculated using J, CG, CGL and MDRD. Results: 3830 evaluable pts had a mean age 58.7yrs, mean BMI 26.8kg/m 2 and mean baseline CrCl J 81.9ml/min (range 23.4-239). The AUC statistics (range 0.52-0.64) show that the log(CrCl J ) was not a good predictor of grade ≥3 AE (anemia, thrombocytopenia, febrile neutropenia, auditory, renal, metabolic, neurologic). A cutoff value of CrCl J &lt;60 ml/min would have deemed 15% of pts treated on GOG182 ineligible. The range of PPV for the above AEs in pts with CrCl J &lt;60 ml/min was 1.8-15%. Using CG, CGL, MDRD instead of J for CPRx would have resulted in &gt;10% decrease in CPRx in 21%, 32% and 12% of pts, respectively. Using CG, CGL, MDRD instead of J for CPRx would have resulted in &gt;10% increase in CPRx in 45%, 9.6% and 5.2% of pts, respectively. Conclusions: Our data do not support excluding patients with CrCl J &lt;60ml/min from clinical trials. The new GOG guidelines replacing J with CGL affect CPRx. The clinical significance of this change with regards to toxicity, particularly in pts with abnormally low Cr values, is yet to be determined.
Systems Biology Approach to Uncover Signaling Defects in Primary Immunodeficiency Diseases (2016)

Abstract To improve diagnoses and further our understanding of functional defects in subjects with primary immunodeficiency (PI) diseases, we developed a new screen to broadly study the signaling of defective human immune responses to infections. Using time-of-flight mass cytometry (CyTOF) and phospho-specific antibodies, we simultaneously examined the major signaling pathways of all circulating innate and adaptive immune cell types in response to cytokines and TLR agonists to identify signaling responses. We studied healthy controls and developed software tools to generate a systematic map of signaling responses. CyTOF successfully recapitulated established signaling responses, and further, elucidated new pathways that would not have been appreciated with traditional studies. Signaling map of controls was compared to maps generated by analyzing PI subjects with gain-of-function STAT1 and autosomal dominant STAT3 deficiency diseases. CyTOF allowed us to perform unbiased studies to uncover many ex-vivo signaling defects simultaneously to better understand how known genetic etiologies manifest functionally, and exactly which cell subtypes are affected. We identified more glaring defective signaling responses in these subjects aside from the canonical defects, elucidating the true breadth of cell subtypes and pathways affected. Broad, unbiased, functional analysis can complement whole exome sequencing to facilitate identification of novel or rare immune diseases. Comprehensive view of signaling across all immune cell subsets facilitates learning more about abnormal signaling patterns that confer susceptibility to infection or autoimmunity, improving our understanding of immune responses and can lead to new therapies.
Release Criteria for Rehabilitated Wild Animals (2013)

The release of a rehabilitated wild animal carries with it the responsibilities of assuring the animal is physically and psychologically fit for release and is released at an appropriate time in an appropriate habitat.
Research on Switching Interconnection Modes and Game Control of Interconnected Air Suspension (2019)

To solve the contradiction between handling stability and ride comfort of vehicles with interconnected air suspension system (IASS) and reduce the energy consumption of air suspension with adjustable spring stiffness, a coordinated control for dynamic performance was designed based on the logic of switching interconnection modes and game control for the damper. The control system consists of a switching controller for air suspension interconnection modes and a distribution controller for the damping force. The switching controller determines the optimal air suspension interconnection mode by calculating the vehicle dynamic performance index in real-time. The distribution controller achieves a distribution for optimal damping force based on an infinite time differential game. veDYNA software that is a vehicle dynamics analysis software based on MATLAB/Simulink was used to verify the algorithm, and the accuracy was verified by a bench test. Finally, the results show this coordinated system can significantly improve the ride comfort and restrain the pitching motion. Compared with traditional suspension, the vertical acceleration decreases by 18.32% and the dynamic stroke decreases by more than 10% under the straight condition; the vertical acceleration decreases by 12.24% and the roll angle decreases by 1.26% under the steering condition.
Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium (2019)

Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all breast cancer-related deaths in the United States. Currently there are no therapeutic regimens developed specifically for IBC, and it is critical to recognize that all aspects of treating IBC - including staging, diagnosis, and therapy - are vastly different than other breast cancers. In December 2014, under the umbrella of an interdisciplinary initiative supported by the Duke School of Medicine, researchers, clinicians, research administrators, and patient advocates formed the Duke Consortium for IBC to address the needs of patients in North Carolina (an ethnically and economically diverse state with 100 counties) and across the Southeastern United States. The primary goal of this group is to translate research into action and improve both awareness and patient care through collaborations with local, national and international IBC programs. The consortium held its inaugural meeting on Feb 28, 2018, which also marked Rare Disease Day and convened national research experts, clinicians, patients, advocates, government representatives, foundation leaders, staff, and trainees. The meeting focused on new developments and challenges in the clinical management of IBC, research challenges and opportunities, and an interactive session to garner input from patients, advocates, and community partners that would inform a strategic plan toward continuing improvements in IBC patient care, research, and education.
Predictors of survival in portopulmonary hypertension: a 20-year experience (2021)

PoPH patients have poor 5-year survival which is strongly associated to the severity of underlying liver disease and not to the hemodynamic severity of PoPH; therefore efforts should be focused in facilitating liver transplantation for these patients.
Effect of increasing electron demand upon the product-determining transition state in the reaction of 4-substituted 2-nitrobenzenesulfenyl chlorides and benzenesulfenyl chlorides with bicyclo[2.2.1]hepta-2,5-diene (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of increasing electron demand upon the product-determining transition state in the reaction of 4-substituted 2-nitrobenzenesulfenyl chlorides and benzenesulfenyl chlorides with bicyclo[2.2.1]hepta-2,5-dieneDennis G. Garratt and Pierre L. BeaulieuCite this: J. Org. Chem. 1979, 44, 20, 3555–3559Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/jo01334a023https://doi.org/10.1021/jo01334a023research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactions of Amino-Containing Peptides with Sodium Silicate and Colloidal Silica:  A Biomimetic Approach of Silicification (2002)

International audience
Mitogenic stimulation of human lymphocyte subpopulations by Lathyrus odoratus lectin. (1979)

Investigation was made of the mitogenic activation by Lathyrus odoratus (LATH) lectin and phytohaemagglutinin (PHA) of human T-enriched and non-T lympohcytes isolated by nylon wool filtration and sheep erythrocyte rosette depletion, respectively. LATH stimulated only weakly the T-enriched and non-T fractions as compared to PHA which strongly stimulated the T-enriched population and weakly stimulated the non-T cells. Removal of phagocytic cells from the unfractionated lymphocytes caused only a slight reduction in the response to LATH. The responses of mixtures of T-enriched and non-T lymphocytes were similar to that of unfractionated lymphocytes. The LATH lectin seems, therefore, to be neither a pure T nor a pure non-T cell mitogen, since both populations must be present for optimal response. When alpha-methyl-D-mannoside was added to unfractionated lymphocytes together with LATH, there was a strong inhibition of thymidine incorporation. D-glucose and N-acetyl-D-glucosamine diminished the stimulation effect to a lesser degree.
Software-compensated programmable temperature controller (1992)

A simple multi-purpose programmable temperature controller is proposed. The proposed circuit employs only two operational amplifiers and a small number of passive components. In this circuit a software compensation approach is utilized to nullify the offset voltage. The idea of obtaining a programmable temperature controller is explored and three different controller approaches are suggested. A novel application of the proposed circuit utilizing a digitally programmable controller was implemented. The circuit offers a wide range of applications, e.g. it could be used to reduce the power dissipation of most devices that have built-in electrical cooling systems. It could also replace most of the available mechanical temperature stabilizers (automotive thermostats), etc. The proposed circuit was built and tested for controlling the cooling fan of a personal computer. A digital-to-analogue converter card was used to program the circuit to generate the desired reference temperature.
General Matrix Inversion Technique for the Calibration of Electric Field Sensor Arrays on Aircraft Platforms (2007)

Abstract A matrix calibration procedure has been developed that uniquely relates the electric fields measured at the aircraft with the external vector electric field and net aircraft charge. The calibration method can be generalized to any reasonable combination of electric field measurements and aircraft. A calibration matrix is determined for each aircraft that represents the individual instrument responses to the external electric field. The aircraft geometry and configuration of field mills (FMs) uniquely define the matrix. The matrix can then be inverted to determine the external electric field and net aircraft charge from the FM outputs. A distinct advantage of the method is that if one or more FMs need to be eliminated or deemphasized (e.g., due to a malfunction), it is a simple matter to reinvert the matrix without the malfunctioning FMs. To demonstrate the calibration technique, data are presented from several aircraft programs (ER-2, DC-8, Altus, and Citation).
N-tert-Butoxy-1-aminopyrenyl Radicals. Isolation, Electronic Structure, and Magnetic Characterization1 (2002)

N-tert-Butoxy-2,7-di-tert-butyl-1-pyrenylaminyl (4), N-tert-butoxy-2-tert-butyl-1-pyrenylaminyl (5), and N-tert-butoxy-7-tert-butyl-1-pyrenylaminyl (6) free radicals were generated by the reaction of the lithium amides of the corresponding 1-aminopyrenes with tert-butyl peroxybenzoate in THF at -78 degrees C. Although 6 could not be isolated due to the gradual decomposition in solution, 4 and 5 were quite persistent and could be isolated as monomeric radical crystals. The X-ray crystallographic analyses for the isolated free radicals were successfully carried out, indicating that the N and O atoms are almost coplanar with the pyrene ring. The ESR spectra of 4 and 5 were very complex due to the presence of many magnetically unequivalent protons. Therefore, the proton hyperfine coupling (hfc) constants were determined by (1)H ENDOR/TRIPLE resonance spectroscopy. To assign the hfc constants for the pyrene ring protons, a partially deuterated radical, 4-d(4), was prepared and the ENDOR and ESR spectra were measured. To discuss the spin density distribution for 4 and 5 ab initio molecular orbital calculations were performed by the DFT UBecke 3LYP method, using the STO 6-31G basis set. Magnetic susceptibility measurements were carried out for 4 and 5 with a SQUID magnetometer. For 4 a weak antiferromagnetic interaction was observed, and for 5 a very strong antiferromagnetic interaction was observed. The antiferromagnetic interactions were explained by their crystal structures.
Mass spectrometry profile as a predictor of overall survival benefit after treatment with epidermal growth factor receptor inhibitors in head and neck squamous cell carcinoma (2009)

6000 Background: Our previous study has shown that a matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) profile in serum or plasma can predict lung cancer patient survival after treatment with epidermal growth factor receptor inhibitors (EGFRI). We examined the ability of this same MALDI-MS profile in plasma or sera to predict for survival benefit of EGFRIs in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Spectra were obtained in triplicate using MALDI-MS from 314 samples obtained from five HNSCC cohorts treated with 1) gefitinib (G, n = 100); 2) erlotinib and bevacizumab (E/B, n = 81); 3) cetuximab (C, n = 21); 4) surgery (S, n = 78); and 5) palliative chemotherapy (PC, n = 34). Each sample was classified into “good” or “poor” outcome groups and overall survival was examined using this MALDI-MS classifier (VeriStrat, Biodesix, Steamboat Springs, CO). Results: Successful classification could be achieved in 311/314 (98%) of the samples. In all EGFRI-treated cohorts, the classifier predicted survival benefit while the cohorts without EGFRI-treatment showed no survival difference by log-rank testing (G: p = 0.007, HR 0.41, 95%-CI 0.22–0.79; E/B: p = 0.02, HR 0.20, 95%-CI 0.05–0.78; C: p=0.06, HR 0.26, 95%-CI 0.06–1.06; and PC: p = 0.76, HR 0.88, 95%-CI 0.4–1.97), independent of performance status, age, gender and smoking history. Conclusions: This study suggests that the same predictive algorithm for MALDI-MS generated from patients with lung cancer treated with EGFRIs is also predictive of survival outcome in HNSCC patients treated with both TKIs and cetuximab, and may allow rational selection of patients most likely to benefit from an EGFRI monotherapy. [Table: see text]