gebhart/patrepeval huggingface dataset:
The Effect of Interleukin‐17 on the Proliferation and Invasion of JEG‐3 Human Choriocarcinoma Cells (2006)

Problem As there has been a study in mice showing the expression of IL‐17 by decidual cells and the status of IL‐17 receptor expression in human pregnancy is not known, we hypothesized that IL‐17 may regulate human trophoblast proliferation and invasion. Method of study JEG‐3 cell line was used as a model for human trophoblast. Immunohistochemitry and reverse transcriptase polymerase chain reaction techniques were used to identify IL‐17 receptor protein and mRNA, respectively. The effects of IL‐17 on JEG‐3 cell proliferation and invasion were tested using the BrdU incorporation and the Matrigel invasion assays, respectively. Results IL‐17 increased the invasive capacity of JEG‐3 cells but had no effect on the proliferation and multinucleated formation of JEG‐3 cells. Conclusion In this JEG‐3 cell model of human trophoblast, the IL‐17R and IL‐17 may have a regulatory role in trophoblast invasion.
Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines (2014)

Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.
EFFECTS OF FRUCTOSE AND GLUCOSE INGESTION ON MUSCLE GLYCOGEN USE DURING SUB MAXIMAL EXERCISE (1982)

Levine, L.; Evans, W. J.; Cadarette, B. S.; Fisher, E. C.; Bullen, B. A. Author Information
Direct contact heat transfer between immiscible fluid layers in laminar flow (1972)

Abstract The problem of heat transfer (and, by analogy, mass transfer) between immiscible fluids in laminar parallel flow is analyzed as a conjugated boundary value problem. Exact solutions are developed in terms of known functions by solving for the temperature fields in the two phases separately for constant boundary conditions, then generalizing the results to obtain solutions for the interfacial temperature distribution and the complete temperature field for the conjugated system. The analysis and the results of calculations for heat transfer between two immiscible films flowing down an adiabatic inclined plane are presented. It is shown that axial conduction can be included, and the effects of axial conduction in one stream are examined. The predicted Nusselt numbers are plotted versus axial position for various parameters, and the interfacial temperatures and mixed mean fluid temperatures for the two phases are plotted to elucidate the heat transfer characteristics.
IL-18 Transgene Mäuse mit leberspezifischer Expression zeigen eine erhöhte spontane Mortalität und eine veränderte Leberarchitektur (2004)

Hintergrund: Interleukin-18 (IL-18) spielt beim FAS-mediierten Leberschaden eine wesentliche Rolle und wurde aus Kupffer Zellen von Mäusen isoliert, die nach vorangegangener sequenzieller Behandlung mit P. acnes und LPS einen schweren Leberschaden hatten. Der genaue Mechanismus des Leberschadens ist unklar. Um den Effekt einer IL-18 Überexpression auf die Immunmodulation der Leber zu studieren und die Bedeutung beim Leberschaden zu klären, haben wir transgene Mäuse generiert, die IL-18 in der Leber überexprimieren.
Synthèse d'époxyphosphonates alpha-chlorés, intermédiaires potentiels dans la préparation de l'analogue phosphoré du KDO, cible privilégiée dans la recherche de nouveaux antibiotiques (1998)

Les epoxyphosphonatesex-chlores ont ete prepares par action de l'acide metachloroperbenzoique (mCPBA) sur les vinylphosphonates ex- chlores. L'isomerisation des epoxyphosphonates est en cours d'etude. Les resultats de ces travaux seront appliques au mannose pour la preparation du KDO phosphore.
Extensions of ITU-T recommendation H.324 for error-resilient video transmission (1998)

The authors provide an overview of techniques that enable the use of ITU-T recommendation H.324 with error-prone transmission channels. H.324 covers the overall architecture, algorithms, and syntax for low-bit-rate multimedia terminals. This overview focuses on extensions for error-resilient video transmission that are related to the H.263 video codec and H.223 multiplex. The latter is responsible for reliable delivery of data to each terminal component and is therefore of major importance to the overall system. In particular, the discussed approaches to robust video transmission require reliable performance of the multiplex scheme. The considered techniques for video coding are either compatible with the baseline mode of H.263 or part of new extensions recently devised by Study Group 16 as part of the H.263+ effort. This overview includes "error tracking" (Appendix II). "reference picture selection" (Annex N), and "independent segment decoding" (Annex R). Whenever appropriate, the description of those video extensions and multiplex schemes is complemented with simulation results for transmission over Rayleigh fading channels.
From Fermi's Golden Rule to the Vacuum Rabi Splitting: Magnetopolaritons in a Semiconductor Optical Microcavity (1995)

We show that magnetic quantization of the carrier free motion into discrete Landau levels for quantum wells inserted in a Fabry-P\'erot microcavity allows continuous tuning of the electromagnetic interaction from the weak coupling regime (irreversible regime described by Fermi's golden rule) to the strong coupling regime (where coherent time dependence and the vacuum Rabi splitting prevail).
Mesenchymal Stem Cells: Angels or Demons? (2011)

Mesenchymal stem cells (MSCs) have been used in cell-based therapy in various disease conditions such as graft-versus-host and heart diseases, osteogenesis imperfecta, and spinal cord injuries, and the results have been encouraging. However, as MSC therapy gains popularity among practitioners and researchers, there have been reports on the adverse effects of MSCs especially in the context of tumour modulation and malignant transformation. These cells have been found to enhance tumour growth and metastasis in some studies and have been related to anticancer-drug resistance in other instances. In addition, various studies have also reported spontaneous malignant transformation of MSCs. The mechanism of the modulatory behaviour and the tumorigenic potential of MSCs, warrant urgent exploration, and the use of MSCs in patients with cancer awaits further evaluation. However, if MSCs truly play a role in tumour modulation, they can also be potential targets of cancer treatment.
Application Of High Speed And High Performance Fluid Film Bearings In Rotating Machinery. (1994)

ing Manager at KMC Inc. in Wes t Green wich, Rhode Is land Mr Paquette has been with KMC fo r six years where he is actively involved in the design, finite element analy sis, rotordynamic analysis, testing, and de velopment of deflection pad and other high performance journal and thrust bearings.
Tunable Extracellular Self-Assembly of Multi-Protein Conjugates from Bacillus subtilis (2016)

The ability to stably and specifically conjugate recombinant proteins to one another is a powerful in vitro technique for engineering multifunctional enzymes, protein therapeutics and novel biological materials. However, for many applications spontaneous in vivo protein conjugation would be preferable to in vitro methods. Exploiting the recently described SpyTag-SpyCatcher system, we describe here how enzymes and structural proteins can be genetically-encoded to covalently conjugate in culture media following programmable secretion by Bacillus subtilis. Using this novel approach, we demonstrate how self-conjugation of a secreted industrial enzyme, XynA, dramatically increases its resilience to boiling and we show that cellular consortia can be engineered to self-assemble functional multi-protein complexes with tunable composition. This genetically-encoded modular system provides a new, flexible strategy for protein conjugation harnessing the substantial advantages of extracellular self-assembly.
Binding and inhibition of human spermidine synthase by decarboxylated S‐adenosylhomocysteine (2011)

Aminopropyltransferases are essential enzymes that form polyamines in eukaryotic and most prokaryotic cells. Spermidine synthase (SpdS) is one of the most well-studied enzymes in this biosynthetic pathway. The enzyme uses decarboxylated S-adenosylmethionine and a short-chain polyamine (putrescine) to make a medium-chain polyamine (spermidine) and 5'-deoxy-5'-methylthioadenosine as a byproduct. Here, we report a new spermidine synthase inhibitor, decarboxylated S-adenosylhomocysteine (dcSAH). The inhibitor was synthesized, and dose-dependent inhibition of human, Thermatoga maritima, and Plasmodium falciparum spermidine synthases, as well as functionally homologous human spermine synthase, was determined. The human SpdS/dcSAH complex structure was determined by X-ray crystallography at 2.0 Å resolution and showed consistent active site positioning and coordination with previously known structures. Isothermal calorimetry binding assays confirmed inhibitor binding to human SpdS with K(d) of 1.1 ± 0.3 μM in the absence of putrescine and 3.2 ± 0.1 μM in the presence of putrescine. These results indicate a potential for further inhibitor development based on the dcSAH scaffold.
Microscale energy transport (1998)

Preface Contributors Part I Fundamentals 1.Microscale Energy Transport in Solids 2.Heat Transport in Dielectric Thin Films and at Solid-Solid Interfaces 3.Microscale Radiation Phenomena 4.Melting and Freezing Phenomena 5.Molecular Clusters 6.Interfacial Forces and Phase Change in Thin Liquid Films Part II.Applications 7.Thermal Phenomena in Semiconductor Devices and Interconnects 8.Micro Heat Pipes 9.Microscale Heat Transfer in Biological Systems at Low Temperatures 10.Silicon Micromachined Thermal Sensors and Actuators Index
c-Myc Suppression of DNA Double-strand Break Repair (2012)

c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s) involved remains elusive. Here, we discovered that γ-ray ionizing radiation-induced DSBs promote c-Myc to form foci and to co-localize with γ-H2AX. Conditional expression of c-Myc in HO15.19 c-Myc null cells using the Tet-Off/Tet-On inducible system results in down-regulation of Ku DNA binding and suppressed activities of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and DNA end-joining, leading to inhibition of DSB repair and enhanced chromosomal and chromatid breaks. Expression of c-Myc reduces both signal and coding joins with decreased fidelity during V(D)J recombination. Mechanistically, c-Myc directly interacts with Ku70 protein through its Myc box II (MBII) domain. Removal of the MBII domain from c-Myc abrogates its inhibitory effects on Ku DNA binding, DNA-PKcs, and DNA end-joining activities, which results in loss of c-Myc's ability to block DSB repair and V(D)J recombination. Interestingly, c-Myc directly disrupts the Ku/DNA-PKcs complex in vitro and in vivo. Thus, c-Myc suppression of DSB repair and V(D)J recombination may occur through inhibition of the nonhomologous end-joining pathway, which provides insight into the mechanism of c-Myc in the development of tumors through promotion of genomic instability.
Service design for behavioural change - current state of the discipline and practice in India (2018)

We investigated the current picture of appreciation, state of relevant knowledge and skills, and practice among the Indian design professionals regarding service design and design for behaviour change. Inter alia, the current scenario regarding the embeddedness and maturity path of service design in academic institutes and industry were studied. Indian society and businesses are facing challenges that are wicked, deep and complex due to the diversity of social, cultural, and economic conditions. They could benefit from a synthesis of service design and design for behavioural change. This study is exploratory in nature. However, it is a significant initial step to emphasize the need of and gaps in the aspects pertaining to effective service design for behavioural change practice in India and suggests indicative interventions. With these interventions, Indian professionals could achieve maturity and be in a position to address the wicked problem India faces.
Many-core event evaluation (2013)

We present a Many-Core Event Evaluation framework for real-time execution of many complex animation schemes applicable to a wide range of domains such as gaming and interactive pre-visualization in studio production. Our technique takes advantages of task parallelism on many-core CPU architecture using a two-level scheduling approach. Our generic approach can deal with tens of thousands event-processing nodes, event loops, non-deterministic and interaction-driven animation modifications at runtime. Versatility is further enforced through a native support of hierarchical animation graphs using prototypes and inline files. Our implementation based on the X3D event-based animation model exhibits performances approaching the theoretical upper bounds of parallelization.
[A manifesting carrier of Duchenne muscular dystrophy presenting mosaic distribution of dystrophin negative and positive muscle fibers]. (1990)

A 25-year-old female patient with an approximate 10-year-history of slowly progressive muscle weakness was diagnosed as a manifesting carrier of Duchenne muscular dystrophy (DMD) because her muscle biopsy showed scattered fibers with no dystrophin on immunohistochemical staining. She had no family history of neuromuscular disorders. She was in good health until about 14 years of age, when she developed muscle weakness and atrophy of the extremities with slow aggravation. On admission at the age of 25 years, she had asymmetrical muscle atrophy in the lower extremities; the left femur, right femur, left crus, and right crus measured 36.0, 40.5, 31.5, and 35.5 cm in circumference, respectively. However, the muscle weakness of the extremities was symmetrical with no laterality, and the proximal muscles in the lower extremities were predominantly affected to 3+/5 MMT test. She walked with a mild wadding manner and stood up with Gower' maneuver. Deep tendon reflexes of the extremities were almost normoactive with no pathologic reflexes. As to laboratory findings, serum enzymes of muscular origin were elevated; GOT was 44 IU/l, GPT 60 IU/l, LDH 829 IU/l, CK 4238 IU/l, and aldolase 31 SL units. The electromyogram showed myopathic changes mixed with some neurogenic components. Peripheral nerve conduction velocity was normal. A computed tomography of the skeletal muscles showed more marked atrophy and lower density in the left lower extremity than in the right. The biopsied left gastrocnemius muscle demonstrated a marked variation in fiber size with some necrotic and regenerating fibers. On immunohistochemical stain with anti-dystrophin antibody, the dystrophin negative fibers were scattered among positive fibers in a mosaic distribution.
Gas Diffusion/Permeation Flow Injection Analysis. Part I. Principles and Instrumentation (1992)

Abstract Gas diffusion/permeation techniques involving different membrane interphases or an open fluid/fluid interface are presented as powerful tools for separation and/or preconcentration of a variety of classes of analytes, i.e., gases, gas-evolving species, volatile inorganic and organic substances, etc., from gaseous, aquatic, or organic sample matrices. Principles of the techniques and factors influencing transmembrane transport, such as acidity of the donor and the acceptor streams, their flow rates, membrane characteristics, temperature, pressure, etc., are described. Different configurations of FIA manifolds for stopped-flow, closed-loop, and continuous flow arrangements, designs of principal instrumental modules, characteristics of different semipermeable membranes, and special arrangements of detection systems are outlined. Key Words: flow injection analysismembrane separationpreconcentrationinstrumentationgas diffusiongas permeation
Operational use of SSM/I ice concentration in the initialization of a coupled ice-ocean model (2005)

The Polar Ice Prediction System (PIPS), the Regional Polar Ice Prediction System - Barents (RPIPS-B) and the Regional Polar Ice Prediction System Greenland Sea (RPIPS-G) are all operational sea ice forecasting systems which have been run daily at the Fleet Numerical Meteorology and Oceanography Center (FNMOC) since September 1987, June 1989 and October 1991, respectively. The basis for all three models is the Hibler ice model. The Hibler ice model calculates ice drift, ice thickness, ice concentration, ice edge and the growth/decay of ice based on both dynamic and thermodynamic effects. The Polar Ice Prediction System 2.0 (PIPS2.O), a new version of PIPS, is presently undergoing its final test phase. PIPS2.0 has been modified into a spherical coordinate version of PIPS and coupled with an ocean model (Cox, 1984). Daily atmospheric fields from the Navy Operational Global Atmospheric Prediction System (NOGAPS) are used to produce a 24-hour forecast. PIPS forecasts over the entire Arctic basin, the Barents Sea and the Greenland/Norwegian Sea using a grid resolution of 127 km. RPIPS-B, a higher resolution version of PIPS, forecasts over the Barents Sea and the western part of the Kara Sea using a grid resolution of 2.5 km. RPIPS-G, another higher resolution version of PIPS, forecasts over the region adjacent to the Fast Greenland coast using a grid resolution of 20 km. PIPS2.0 forecasts over most of the ice-covered regions in the northern hemisphere using a variable grid resolution ranging from 17 to 33 km at the North Pole. By the end of 1994, PIPS2.0 will replace all the existing operational forecast sytems at FNMOC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
2‐Cyclopentene‐1,4‐Dione (2003)

Abstract 2‐Cyclopentene‐1,4‐dione product: 2‐cyclopentene‐1,4‐dione
Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. (1987)

In order to test the requirement of Na channel inactivation for the action of local anesthetics, we investigated the inhibitory effects of quaternary and tertiary amine anesthetics on normally inactivating and noninactivating Na currents in squid axons under voltage clamp. Either the enzymatic mixture pronase, or chloramine-T (CT), a noncleaving, oxidizing reagent, was used to abolish Na channel inactivation. We found that both the local anesthetics QX-314 and etidocaine, when perfused internally at 1 mM, elicited a "tonic" (resting) block of Na currents, a "time-dependent" block that increased during single depolarizations, and a "use-dependent" (phasic) block that accumulated as a result of repetitive depolarizations. All three effects occurred in both control and CT-treated axons. As in previous reports, little time-dependent or phasic block by QX-314 appeared in pronase-treated axons, although tonic block remained. Time-dependent block was greatest and fastest at large depolarizations (Em greater than +60 mV) for both the control and CT-treated axons. The recovery kinetics from phasic block were the same in control and CT-modified axons. The voltage dependence of the steady state phasic block in CT-treated axons differed from that in the controls; an 8-10% reduction of the maximum phasic block and a steepening and shift of the voltage dependence in the hyperpolarizing direction resulted from CT treatment. The results show that these anesthetics can bind rapidly to open Na channels in a voltage-dependent manner, with no requirement for fast inactivation. We propose that the rapid phasic blocking reactions in nerve are consequences primarily of channel activation, mediated by binding of anesthetics to open channels, and that the voltage dependence of phasic block arises directly from that of channel activation.
Synthesis and photocatalytic activity of titanium oxinitride Ti(O, N) and Pd-Ti(O,N) nanoparticles (2016)

SSCI-VIDE+CARE+FDA:CGU
Gene finding in the chicken genome (2005)

De novo comparative gene prediction followed by experimental verification is effective at enhancing the annotation of the newly sequenced genomes provided by standard homology-based methods.
GCMS Analyses of Chemical Vapor Deposition Precursors (2000)

No abstract prepared.
Corn Particle Size Affects Nutritional Value of Simple and Complex Diets for Nursery Pigs and Broiler Chicks (2002)

Two experiments were conducted to determine the effects of reducing particle size of corn from 1,000 to 500 m in simple and complex diets for nursery pigs and broiler chicks. In Exp 1., 192 nursery pigs were used in a 24 d growth assay. Treatments were: 1) 1,000 m corn in a simple diet; 2) 500 m corn in a simple diet; 3) 1,000 m corn in a complex diet; and 4) 500 m corn in a complex diet. Overall, pigs fed complex diets had 9% greater ADG (p<0.005) and 5% greater gain/feed (p<0.01) compared to pigs fed simple diets. Also, pigs fed the 500 m treatments had 3% better overall gain/feed than those fed the 1,000 m treatments (p<0.007). At d 9, apparent digestibilities of DM, N and GE were greater for complex diets and diets with smaller particle size (p<0.02). At d 23, there were no differences in nutrient digestibility resulting from diet complexity, but pigs fed diets with corn ground to 500 m had greater digestibility of DM (p<0.02) and GE (p<0.003) than pigs fed diets with corn ground to 1,000 m. A second experiment was designed to determine if four days old broiler chicks were an acceptable model for predicting the effects of feed processing procedures on nursery pigs. Chicks fed complex diets had 3% greater gain/feed than chicks fed simple diets (p<0.001). Rate of gain and feed intake were improved by 3 and 2%, respectively, for chicks fed crumbled diets (p<0.03). However, there were several significant interactions among the main effects. For instance, crumbling did not affect gain/feed in chicks fed complex diets, but rate of gain and feed intake were increased by 7 and 6%, respectively, when simple diets were crumbled (diet complexitydiet form, p<0.001). Also, gain/feed of chicks was improved by 3% when particle size was reduced in meal diets, but not affected in chicks fed crumbles (diet formparticle size, p<0.005). Thus, our data suggested that reduction of particle size of corn was important for simple and complex diets and that a complex diet with 1,000 m corn gave no better performance than a simple diet with 500 m corn.
Reactions with heterocyclic amidines 1. Cyanoethylation of cyclic amidines (1978)

Abstract 2‐Amino‐5‐phenyl‐1,3,4‐oxadiazole ( 1a ) and 2‐amino‐1,3,4‐thiadiazole ( 1b ) reacted with acrylonitrile to yield β‐cyanoethylamino derivatives. On the other hand, 2‐amino‐4‐phenylthiazole ( 2 ) reacted with acrylonitrile under the same experimental conditions to yield a di‐β‐cyanoethylaminothiazole derivative. 3‐Phenyl‐Δ 2 ‐1,2,4‐triazoline‐5‐thione reacted with acrylonitrile to yield the corresponding adduct. The structure of the adduct was established by its conversion into the acid 13 which could be synthesised via another independent route.
Synthesis and Structural Characterization of K0.33Gd0.67F2.33 (KGd2F7) and K0.31Gd0.69F1.84O0.27. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
“Spot” ECGs Underestimate Atrial Fibrillation Recurrence after Surgical Ablation (2008)

: "Spot" ECGs underestimate the incidence of recurrent AF after surgical ablation for AF and show poor agreement with the more reliable 1-week autocapture event recordings.