gebhart/patrepeval huggingface dataset:
Design and implementation of flexible 4M&#x00D7;4N MIMO channel emulator (2014)

This paper presents a scalable hardware architecture of multi-input multi-output (MIMO) channel emulator. The basic 4×4 MIMO emulator hardware module is designed and implemented based on Viretex-6 FPGA with 100MHz bandwidth. Complexity and used resource are analyzed. Furthermore, the relative error of fixed-point and float-point simulation are compared for implementation. In particular, this design methodology allows for extending to 4M×4N MIMO channel emulation.
Effect of captopril treatment on proteinuria in NZB/NZW F1 hybrid mice. (1988)

Oral treatment of female NZB/NZW F1 hybrid mice with captopril prevented the development of proteinuria and prolonged survival in mice demonstrating slight (trace to 1+) proteinuria. Captopril treatment also markedly reduced the incidence and magnitude of proteinuria and prevented death in mice showing significant (3+ or greater) proteinuria. Histopathological studies of the kidneys of treated mice further demonstrated improvements in the renal lesions of autoimmune mice. The mechanisms whereby captopril treatment influences the course of disease in NZB/NZW mice are not known.
ROUNDABOUT Receptors (2013)

Roundabout receptors (Robo) and their Slit ligands were discovered in the 1990s and found to be key players in axon guidance. Slit was initially described s an extracellular matrix protein that was expressed by midline glia in Drosophila. A few years later, it was shown that, in vertebrates and invertebrates, Slits acted as chemorepellents for axons crossing the midline. Robo proteins were originally discovered in Drosophila in a mutant screen for genes involved in the regulation of midline crossing. This ligand-receptor pair has since been implicated in a variety of other neuronal and non-neuronal processes ranging from cell migration to angiogenesis, tumourigenesis and even organogenesis of tissues such as kidneys, lungs and breasts.
Hepatocellular Neoplasms Arising in Association With Androgen Use (2015)

Correlation between androgen use and hepatocellular neoplasia is well established. However, there are no detailed studies of the histopathology and immunohistochemical/molecular profile of these tumors. We studied 9 patients with androgen-associated hepatocellular neoplasms. In addition to histology, immunostains for liver fatty acid-binding protein, β-catenin, glutamine synthetase, C-reactive protein, and serum amyloid A were utilized for tumor subtyping. Molecular testing using Solid Tumor Targeted Cancer Panel was performed on 3 cases. The neoplasms were predominantly seen in male individuals (7/9). Two patients (22%) had multifocal lesions. All lesions had architectural and 4/9 had cytologic atypia. Cholestasis was present in 6/9 cases. Reticulin was focally disrupted in 5/9 cases. Given the clinical setting, all lesions were classified as well-differentiated hepatocellular neoplasms of uncertain malignant potential. In cases with follow-up (6/9 cases, 67%), there were no recurrences or metastases. On the basis of the immunoprofile, 7 (78%) cases were β-catenin activated (including 1 hepatic adenoma with concurrent hepatocyte nuclear factor 1α inactivation) and 2 (22%) had inflammatory phenotype. Somatic mutations in CTNNB1 were detected in all 3 tested cases (all β-catenin activated by immunostain), all involving exon-3. Our data indicate that androgen-associated hepatocellular neoplasms most often develop in male individuals and always show some degree of atypia and/or focal reticulin disruption. Most are β-catenin activated, often harboring CTNNB1 exon-3 mutations, and a minority is inflammatory type. Although β-catenin and inflammatory pathways likely play a role in pathogenesis, the heterogenous molecular profile suggests there are other (yet to be characterized) primary oncogenic mechanisms in this unique tumor type.
Sound source localization for robot auditory systems (2009)

Sound source localization (SSL) is a major function of robot auditory systems for intelligent home robots. The steered response power-phase transform (SRP-PHAT) is a widely used method for robust SSL. However, it is too slow to run in real time, since SRP-PHAT searches a large number of candidate sound source locations. This paper proposes a search space clustering method designed to speed up the SRPPHAT based sound source localization algorithm for intelligent home robots equipped with small scale microphone arrays. The proposed method reduces the number of candidate sound source locations by 30.6% and achieves 46.7% error reduction compared to conventional methods.
Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis (2018)

Abstract The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the tumor microenvironment can result in accelerated tumor growth, calling for a detailed characterization of the cellular context to fully comprehend HIF-1’s role in tumorigenesis. We dissected cell type-specific functions of HIF-1 for intestinal tumorigenesis by lineage-restricted deletion of the Hif1a locus. Intestinal epithelial cell-specific Hif1a loss reduced activation of wnt/β-catenin, tumor-specific metabolism and inflammation, significantly inhibiting tumor growth. Deletion of Hif1a in myeloid cells reduced the expression of fibroblast-activating factors in tumor-associated macrophages resulting in decreased abundance of tumor-associated fibroblasts and robustly reduced tumor formation. Interestingly, hypoxia was detectable only sparsely and without spatial association with nuclear HIF-1α in intestinal adenomas, pointing towards a functional importance of hypoxia-independent, i.e. non-canonical HIF-1 stabilization that has not been previously appreciated. This adds a further layer of complexity to the regulation of HIF-1α and suggests that hypoxia and HIF-1α stabilization can be uncoupled in cancer. Collectively, our data show that HIF-1 is a pivotal pro-tumorigenic factor for intestinal tumor formation, controlling key oncogenic programs in both the epithelial tumor compartment and the tumor microenvironment.
Prognostic utility of human complement factor H related protein test (the BTA stat®Test) (2001)

The purpose of the study was to determine, in addition to well-known prognostic factors, histological grade, stage, tumour size and multiplicity, the correlation of BTA stat Test on disease free interval (DFI) on primary superficial bladder cancer. A total of 116 patients with newly diagnosed bladder cancer were evaluated in a prospective multicentre study. A voided urine sample was obtained prior to TURB and split for culture, cytology and BTA stat testing. Follow-up data for the patients were collected until the first recurrence or the last visit and the DFI was analysed by Kaplan-Meier method and Cox analysis. Ninety-seven of the 116 (83.6%) patients were eligible for analysis. The BTA stat Test was positive in 73 (75.3%) patients, whereas cytology detected 20 (20.6%) cases. The DFI was found to be shorter among patients with a positive BTA stat Test, and also among those with intermediate or high-grade tumours. The BTA stat Test result divided patients with grade 2 tumours into two prognostic groups, in that those testing positive had 68.6% risk of recurrence during the first year compared to 42.9% risk of those with a negative test result (P = 0.041). Although the effect of tumour size on DFI was notable, the difference did not reach statistical significance (P = 0.064). Number of tumours was not related to DFI, nor was the difference between different stage of tumour of significance. BTA stat Test is not only sensitive in detection of primary bladder cancer, but also might have some independent prognostic significance.
NASA's Surface Deformation and Change Mission Study (2021)

The National Academies of Science, Engineering and Medicine 2017 Decadal Survey of Earth Science and Applications identified geodetic measurements of surface deformation and related change as one of the top five “observables” to be prioritized in NASA's future program. In response, NASA commissioned a multi-center Surface Deformation and Change (SDC) team to perform a five year study of mission architectures that would support SDC observables and provide the most value to the diverse science and applications communities it serves. The study is being conducted in phases, in which the science and applications capabilities identified in the Decadal Survey are refined, candidate architectures and associated technologies to support these needs are identified, architectures are assessed against a science value framework specific to SDC, and recommendations to NASA are made. Ultimately, NASA will decide which amongst these recommendations will proceed to mission formulation. As synthetic aperture radar (SAR) was identified as the prime sensor technology to satisfy SDC observational needs, a key component of the SDC study is to assess the current state of the art in SAR sensor and supporting technology. The number of SAR systems, both civil and commercial, is growing rapidly, requiring that mission architectures not only consider technology, but availability of data from other missions, possible partnerships or collaborations, and even data purchase. The mechanism for assessment involves development of an end-to-end science performance evaluation tool for multi-satellite constellations, which feeds into a science value framework that considers science performance, technological programmatic risks, and cost. This paper will present an overview of the ongoing study including the candidate architectures and the technology road map needed to achieve the objectives of the mission.
Near-infrared absorption-induced switching effect via guided mode resonances in a graphene-based metamaterial (2019)

Optical switches based on dielectric nanostructures are highly desired at present. To enhance the wavelength-selective light absorption, and achieve an absorption-induced switching effect, here we propose a graphene-based metamaterial absorber that consists of a dielectric grating, a graphene monolayer, and a photonic crystal. Numerical results reveal that the dual-band absorption with an ultranarrow spectrum of the system is enhanced greatly due to the critical coupling, which is enabled by the combined effects of guided mode resonances and photonic band gap. The quality factor of the absorber can achieve a high value (>500), which is basically consistent with the coupled mode theory. Slow light emerges within the absorption window. In addition, electrostatic gating of graphene in the proposed structure provides dynamic control of the absorption due to the change of the chemical potential of the graphene, resulting in an optional multichannel switching effect. Unlike other one-dimensional devices, these effects can be applied to another polarization without changing the structure parameters, and the quality factor is significantly enhanced (>1000). The tunable light absorption offered by the simple structure with an all-dielectric configuration will provide potential applications for graphene-based optoelectronic devices in the near-infrared range, such as narrowband selective filters, detectors, optical switches, modulators, slow optical devices, etc.
Optimal eigenfeature selection by optimal image registration (2003)

Large collections of images cam be indexed by projections on a few "eigenfeatures" the dominant eigenvectors of the images covariance matrix. A preliminary step of registering the images is common practice. A quantitative analysis is being gained by registration was not performed in previous work, and heuristics were used to determine on what to register the images. We show that the registration improves the accuracy of indexing and optimal improvement is obtained when the images are registered on their eigenfeatures subspace. Similarly, if multiple images are to be registered on a subspace, the optimal subspace is the one spanned by the dominant eigenfeatures of the registered images. An algorithm that simultaneously registers the images and computes their eigenfeatures is proposed. The key idea is to iterate the following two steps: 1. Eigenfeatures are computed from the images. 2. New images are computed by registering the images on the subspace of these eigenfeatures. In the next iteration, Step 1 is applied to the set of images that were most recently computed in Step 2. It is demonstrated that the algorithm produces improved eigenfeatures and registers multiple images.
Comparing symptoms of visually induced motion sickness among viewers of four similar virtual Environments with different color (2007)

This paper reports an experiment conducted to study the effects of changing scene color inside a virtual environment on the rated levels of nausea among sixty-four viewers. Current theory on visually induced motion sickness suggests that changing the color of dynamically moving visual stimuli, while keeping everything equals, will not affect the rated sickness symptoms of the viewers. Interestingly, a recent study by another authors reported that color do affect levels of visually induced motion sickness. Preliminary results of this experiment suggest that while exposure duration to the visual stimuli significantly increased the rated levels of nausea and simulator sickness questionnaire scores (p&lt;0.001, ANOVAs), changes of color did not affect the levels of sickness. Reasons for the conflicting results are discussed in the paper. © Springer-Verlag Berlin Heidelberg 2007.
Force control of two-mass resonant system with vibration suppression based on modal transformation (2012)

This paper proposes a force control of a two-mass resonant system based on modal transformation. In the conventional force-control method in resonant system, the control goals are not clearly defined from the point of the view of control stiffness. Moreover, there is a problem that it is needed to know value of an environmental stiffness for setting force gain. Therefore, in this paper, the control stiffness in the case of force control of the two-mass resonant system is defined on the modal spaces which are composed of rigid and torsional modes. Concretely speaking, in the force control, it is defined that a control stiffness of a rigid mode should be zero. Based on the control stiffness, a force control of the two-mass resonant system is designed. Vibration suppression is conducted in torsional mode. On the other hand, in rigid mode, force control is conducted. The validity of the proposed method is verified by both simulation and experimental results.
Curvature control of silicon microlens for THz dielectric antenna (2012)

We have controlled the curvature of silicon microlens by changing the amount of photoresist in order to microfabricate hemispherical silicon microlens which can improve the directivity and reduce substrate mode losses.
Yeast fatty acid synthase: structure to function relationship (1985)

The yeast fatty acid synthase is a multifunctional enzyme composed of two nonidentical subunits in an alpha 6 beta 6 complex that is active in synthesizing fatty acids. The seven catalytic activities required for fatty acid synthesis are divided between the alpha and beta subunits such that the alpha 6 beta 6 complex has six complements of each activity. It has been proposed that these are organized into six centers for fatty acid synthesis. There are different opinions regarding the operation of these centers in the alpha 6 beta 6 complex, on view being that they are functionally independent and the other proposes half-sites activity for the complex. We have attempted to distinguish between these proposals by the most direct method of active site titration, i.e., quantitation of fatty acyl product in the absence of turnover. This was accomplished by using p-nitrophenyl thioacetate and thiophenyl malonate (in place of the coenzyme A analogues) as substrates along with NADPH, thereby depriving the yeast synthase of coenzyme A required to release product as fatty acyl coenzyme A. The amount of fatty acyl product formed was quantitated by gas-liquid chromatography, as well as by direct estimation of radioactivity in the product when p-nitrophenyl thio [1-14C] acetate was used as a substrate. In both cases, a stoichiometry of close to six was found for mole of fatty acid synthesized per mole of alpha 6 beta 6 complex. This indicates that there are six functional centers for fatty acid synthesis in the multifunctional yeast alpha 6 beta 6 fatty acid synthase and that these centers operate independently.(ABSTRACT TRUNCATED AT 250 WORDS)
Low-temperature transport properties of multigraphene films grown on the SiC surface by sublimation (2011)

Multigraphene films grown by sublimation on the surface of a semi-insulating 6H-SiC substrate have been studied. It is shown that pregrowth annealing of the substrate in a quasiclosed growth cell improves the structural quality of a multigraphene film. Ohmic contacts to the film have been fabricated, and the Hall effect has been studied at low temperatures. It is found that a 2D electron gas exists in the films. It is concluded that the conductivity of the film is determined by defects existing within the graphene layer or at the interface between the graphene film and a SiC substrate.
Combined Effects of Fe(III)-Bearing Clay Minerals and Organic Ligands on U(VI) Bioreduction and U(IV) Speciation (2021)

Reduction of U(VI) to U(IV) drastically reduces its solubility and has been proposed as a method for remediation of uranium contamination. However, much is still unknown about the kinetics, mechanisms, and products of U(VI) bioreduction in complex systems. In this study, U(VI) bioreduction experiments were conducted with <i>Shewanella putrefaciens</i> strain CN32 in the presence of clay minerals and two organic ligands: citrate and EDTA. In reactors with U and Fe(III)-clay minerals, the rate of U(VI) bioreduction was enhanced due to the presence of ligands, likely because soluble Fe<sup>3+</sup>- and Fe<sup>2+</sup>-ligand complexes served as electron shuttles. In the presence of citrate, bioreduced U(IV) formed a soluble U(IV)-citrate complex in experiments with either Fe-rich or Fe-poor clay mineral. In the presence of EDTA, U(IV) occurred as a soluble U(IV)-EDTA complex in Fe-poor montmorillonite experiments. However, U(IV) remained associated with the solid phase in Fe-rich nontronite experiments through the formation of a ternary U(IV)-EDTA-surface complex, as suggested by the EXAFS analysis. Our study indicates that organic ligands and Fe(III)-bearing clays can significantly affect the microbial reduction of U(VI) and the stability of the resulting U(IV) phase.
SIP mobility and IPv4/IPv6 dual‐stack supports in 3G IP multimedia subsystem (2006)

Abstract In the Universal Mobile Telecommunications System (UMTS), session initiation protocol (SIP) and IPv6 are the default protocols for IP multimedia core network subsystem (IMS). However, a user equipment (UE) may not be allowed to roam or hand off from UMTS to a private‐IPv4 GPRS network. In this paper, we utilize SIP mobility and an automatic IPv6 tunneling mechanism, called Teredo, to support roaming/handoff of a UE between different networks. We have developed the first non‐commercial Linux‐based Teredo mechanism, and compared our solution with other Teredo implementations in the public domain. Our study indicates that our solution can reduce the tunneling overhead and transmission delay over two other implementations by 44–74%. Copyright © 2006 John Wiley &amp; Sons, Ltd.
Drug-Induced Hypersensitivity Syndrome Associated with Human Herpesvirus 6 and Cytomegalovirus Reactivation (2005)

We describe a patient with drug-induced hypersensitivity syndrome (DIHS) associated with human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) infection induced by sulfasalazine. Two weeks after starting sulfasalazine to treat a rectal ulcer, the patient developed disseminated macular erythema accompanied by fever, liver injury, and lymphadenopathy. Seroconversion of antibodies to HHV-6 was observed. Systemic steroid treatment was not effective against the eruptions. Five months after the onset, he presented with an acute febrile disease. The detection of CMV antigen on peripheral blood leukocytes and positive staining for CMV on cutaneous endothelium indicated active CMV infection. Furthermore, he developed a bacteremia of methicillin resistant Staphylococcus aureus. An association the CMV reactivation with DIHS was suggested, although there remains the possibility that the systemic steroid treatment precipitated CMV reactivation. Recently, HHV-6 has been documented to have immunomodulating effects and to be associated with CMV reactivation. Therefore, we should pay attention to the possibility of CMV reactivation in patients with DIHS in whom the immunomodulating virus of HHV-6 has been reactivated.
Deletion of Arno Reduces Eosinophilic Inflammation and Interleukin-5 Expression in a Murine Model of Rhinitis (2021)

These data demonstrate that deletion of <i>Arno</i> reduces eosinophilic inflammation and IL-5 expression in an OVA-induced model of rhinitis.
Investigations of the Copper Bromide−2,2‘-Dipyridyl System:  Hydrothermal Synthesis and Structural Characterization of Molecular Cu3Br4(C10H8N2)2, One-Dimensional CuBr2(C10H8N2), and Two-Dimensional [Cu2(OH)2(C10H8N2)2][Cu4Br6] (1999)

The hydrothermal reactions of CuBr(2), CuBr, and 2,2'-dipyridyl have resulted in the synthesis of three new compounds. Cu(3)Br(4)(C(10)H(8)N(2))(2) (1) is a molecular phase; CuBr(2)(C(10)H(8)N(2)) (2) is a one-dimensional chain structure; and [Cu(2)(OH)(2)(C(10)H(8)N(2))(2)][Cu(4)Br(6)] (3) crystallizes in a two-dimensional sheet structure. All three compounds were characterized by single-crystal X-ray diffraction. Crystal data for 1, triclinic, space group P&onemacr; (No. 2) with a = 10.604(2) Å, b = 11.642(2) Å, c = 11.688(2) Å, alpha = 61.965(5) degrees, beta = 68.965(5) degrees, gamma = 69.523(5) degrees, Z = 2; 2, monoclinic, space group C2/c (No. 15) with a = 16.766(4) Å, b = 9.287(2) Å, c = 7.392(2) Å, beta = 110.536(6) degrees, Z = 4; 3, monoclinic, space group P2(1)/n (No. 14) with a = 10.907(3) Å, b = 6.0677(13) Å, c = 21.620(5) Å, beta = 90.542(4) degrees, Z = 4.
All-optical tunable photonic crystal cavity (2010)

We demonstrate an ultra-small photonic crystal cavity with two resonant modes.An all-optical tuning operation based on the free-carrier plasma effect is, for the first time, realized utilizing a continuous wave light source.The thermo-optical effect is minimized by isopropanol infiltration of the photonic crystal structure.Figure 1.(a) Schematic of the L3 based PhC cavity.(b) SEM picture of the fabricated structure.(c) (Left) Dispersion diagram for the PhC structure in waveguide region (solid lines) and the cavity region (dashed lines).(Right) Simulated transmission for the proposed structure.
Wide-Bandwidth Logarithmic Amplifier for Analyzing Decay Kinetics (1969)

A logarithmic amplifier is described which converts exponential signals to linear signals. The slope of the latter is inversely proportional to the decay constant or lifetime. This instrument facilitates the measurement of such phenomena as luminescence lifetimes and improves the accuracy of such measurements.
Structure of the Cell Wall of Staphylococcus aureus, Strain Copenhagen. I. Preparation of Fragments by Enzymatic Hydrolysis (1963)

peer reviewed
A new approach to image fusion based on cokriging (2005)

We consider the image fusion problem involving remotely sensed data. We introduce cokriging as a method to perform fusion. We investigate the advantages of fusing Hyperion with ALI. This evaluation is performed by comparing the classification of the fused data with that of input images and by calculating well-chosen quantitative fusion quality metrics. We consider the invasive species forecasting system (ISFS) project as our fusion application. The fusion of ALI with Hyperion data is studied using PCA and wavelet-based fusion. We then propose utilizing a geostatistical based interpolation method called cokriging as a new approach for image fusion.