gebhart/patrepeval huggingface dataset:
Pre-Steady-State Kinetic Studies of Saccharomyces cerevisiae MyristoylCoA:Protein N-Myristoyltransferase Mutants Identify Residues Involved in Catalysis (2001)

MyristoylCoA:protein N-myristoyltransferase (Nmt, EC 2.3.1.97), a member of the GCN5 acetyltransferase (GNAT) superfamily, is an essential eukaryotic enzyme that catalyzes covalent attachment of myristate (C14:0) to the N-terminal Gly of proteins involved in myriad cellular functions. The 2.5 A resolution structure of a ternary complex of Saccharomyces cerevisiae Nmt1p with a bound substrate peptide (GLYASKLA) and nonhydrolyzable myristoylCoA analogue [Farazi, T. A., et al. (2001) Biochemistry 40, 6335] was used as the basis for a series of mutagenesis experiments designed to define the enzyme's catalytic mechanism. The kinetic properties of an F170A/L171A Nmt mutant are consistent with the proposal that their main chain amides, located in a beta-bulge structure conserved among GNATs, function as an oxyanion hole to polarize the thioester carbonyl of bound myristoylCoA prior to subsequent nucleophilic attack. Removal of the two C-terminal residues (M454 and L455) produces a 300--400-fold reduction in the chemical transformation rate and converts the rate-limiting step from a step after the transformation to the transformation event itself. This finding is consistent with the main chain C-terminal carboxylate of L455 functioning as a catalytic base that abstracts a proton from the N-terminal Gly ammonium of the bound peptide to generate the nucleophilic amine. Mutating N169 and T205 in concert reduces the rate of the chemical transformation, supporting their role as components of an H-bonding network that facilitates attack of the Gly1 amine and stabilizes the tetrahedral intermediate.
Support Vector Machine Model: A New Methodology for Stuck Pipe Prediction (2013)

Abstract Stuck pipe is a common worldwide drilling problem, resulting significant increases in non-productive time and overall well cost. Many oil and gas reservoirs are mature and are becoming increasingly depleted of hydrocarbons which make stuck pipe more severe risks. This is due to the fact that decreasing pore pressure increases the chance of stuck pipe. Minimizing the risks of stuck pipe while drilling has been the goal of many operators recently. This paper describes a robust support vector regression (SVR) methodology that offers superior performance for stuck pipe prediction either mechanically or differentially using available drilling parameters. A new model is developed using drilling parameters such as measured depth, mud weight, plastic viscosity, yield point, gel strengths, PH and solid percent from different wells. The method incorporates hybrid least square support vector regression and Coupled Simulated Annealing (CSA) optimization technique (LSSVM-CSA) for efficient tuning of SVR hyper parameters. The algorithm is applied to classify the stuck types, i.e., differential stuck or mechanical stuck. Performance analysis shows that LSSVM classifier has high accuracy. Using intelligent system would help drilling industry to reduce Non-Productive Time (NPT) during operation in complex zones.
Stabilizing heterostructures of soft perovskite semiconductors (2019)

Here we report a solution-processing strategy to stabilize the perovskite-based heterostructure. Strong Pb-Cl and Pb-O bonds formed between a [CH(NH<sub>2</sub>)<sub>2</sub>] <i><sub>x</sub></i> [CH<sub>3</sub>NH<sub>3</sub>]<sub>1-</sub> <i><sub>x</sub></i> Pb<sub>1+</sub> <i><sub>y</sub></i> I<sub>3</sub> film with a Pb-rich surface and a chlorinated graphene oxide layer. The constructed heterostructure can selectively extract photogenerated charge carriers and impede the loss of decomposed components from soft perovskites, thereby reducing damage to the organic charge-transporting semiconductors. Perovskite solar cells with an aperture area of 1.02 square centimeters maintained 90% of their initial efficiency of 21% after operation at the maximum power point under AM1.5G solar light (100 milliwatts per square centimeter) at 60°C for 1000 hours. The stabilized output efficiency of the aged device was further certified by an accredited test center.
Purification and characterization of endo‐xylanases from Aspergillus niger. I. Two isozymes active on xylan backbones near branch points (1985)

Two endo-xylanases (1,4-beta-D-xylan xylanohydrolase, EC 3.2.1.8) were purified to homogeneity from a crude Aspergillus niger pentosanase preparation by Ultrogel AcA 54 gel permeation chromatography, SP-Sephadex C-25 cation exchange chromatography at pH 4.5, Sephadex G-50 gel permeation chromatography, and a second SP-Sephadex C-25 step, this one at pH 5.8. The two xylanases hydrolyzed soluble xylan more rapidly than insoluble branched xylan, but attacked each substance to an equal extent. Their low activity on a linear xylooligosaccharide mixture and absence of activity on insoluble xylan freed of branches suggest that the xylanases require a branch point nearby for significant attack. No xylose or L-arabinose was produced, the major products of low molecular weight being tri- and pentasaccharides and smaller amounts of di-, tetra-, and hexasaccharides. There was low activity on untreated and crystalline cellulose and on carboxymethylcellulose and no activity on other polysaccharides tested. These two xylanases had molecular weights of ca. 1.3 x 10(4) and similar amino acid profiles, high in acidic and low in sulfur-containing residues. Isoelectric points were 8.6 for I and 9.0 for II. Optimum pH values for activity were 6.0 and 5.5, respectively. In a 20-min assay at pH 5.5, each was most active at 45 degrees C, with activation energies up to 40 degrees C of 30.4 and 38.8 kJ/ mol, respectively. Optimum pH levels for stability were 5.0 and 6.0, with half-lives at 60 degrees C and those pHs of 20 and 75 min, respectively.
High Speed and High Resolution ISO A4 Size Amorphous Si:H Contact Linear Image Sensor (1984)

A contact linear image sensor has been developed as a new device to satisfy the requirement for facsimile equipment size reduction. An amorphous Si (a-Si:H) metal insulator semiconductor (MIS) photodiode, which has the excellent small dark current characteristics, is used as the photosensing element. In this sensor element the thermal stability of the electrode material was examined and optimum material was selected. For detecting signals stored in the photosensing elements, 64 bit/ chip integrated circuits (IC's) with a new driving method, which achieves the low noise and high speed operation, were designed and developed. These IC's are mounted on the sensor device substrate. International Standards Organization (ISO) A4 size 8 elements/mm and 12 elements/ mm sensor units in light-emitting diode (LED) light source have been developed. The sensor units characteristics in practical use give signal/ noise ratio (SNR) of 30 dB at 1.5-2.5 ms/line.
Using semantics in non-context-free parsing of montague grammar (1982)

... This paper describes how semantics can be used during parsing to reduce the combinatorial explosion of syntactic ambiguity in Montague grammar. A parsing
Performance evaluation of silicon and gallium nitride power FETs for DC/DC power converter applications (2010)

Detailed performance evaluation of silicon and GaN power FETs is presented for chip-scale DC/DC converter applications. It is shown that improved GaN power FETs and silicon MOS power diodes can potentially lead to nearly 90% power conversion efficiency when switched at 5 MHz in a synchronous buck converter topology.
Malignant Hyperthermia: (1981)

Abstract A case of suspected malignant hyperthermia in a neurosurgical patient is presented. The syndrome complex. treatment. and complications are reviewed and discussed.
The integration of city models and GNSS for the simulation and modeling of multipath and availability: Paving the way for new applications (2008)

Positioning in the urban environment, using Global Navigation Satellite Systems (GNSS), is hampered by poor satellite availability due to signal obstruction and disruption caused by both manmade and natural features of the urban environment. In addition, range measurement to satellites for positioning and for navigation, is severely degraded by the presence of reflected and diffracted signals. The arrival and continuous enhancement of computerised geometric environment models, makes it possible to tackle these problems through mathematical modelling. Environment models have been used by architects and town planners for around thirty years. Within the last decade city model quality in terms of coverage, level of detail and geometric accuracy, has increased. Consequently, the number of applications for such models is continuously increasing and this ensures their continued availability and future usage. Currently, accurate prediction of satellite availability, particularly in cities, is extremely problematic. This thesis presents research undertaken into the use of environment models for the accurate prediction of satellite availability. A software simulator has been developed in order to accurately predict satellite availability, taking as input any environment model. Line of sight (LOS), Fresnel zone, diffracted propagation and reflected signal propagation models have been implemented in the simulator. Validation of each signal propagation model has been performed by comparison of observed data with corresponding simulated outputs. Successful validation of the Fresnel and diffracted propagation models, presented in this thesis, clearly indicate an enhancement over the use of conventional LOS propagation models alone. The reflected propagation model provides a potentially significant enhancement to the area of multipath modelling. It is certain that this work is of importance for mobile positioning devices. With the arrival of greater computational resources inside GNSS receivers, this research is likely to provide a means of reducing positioning errors due to multipath.
Links between sleep and body mass index in bipolar disorders: An exploratory study (2014)

The findings suggest a link between a high BMI and several sleep disturbances in BD, including lower sleep efficiency. Physiological mechanisms in BD cases may include an exaggeration of phenomena observed in non-clinical populations. However, larger scale studies are required to clarify the links between metabolic and sleep-wake cycle disturbances in BD.
Hybrid Sensing and Adaptive Control for Direct Brain Actuation of Artificial Limbs (2011)

Developing a non-invasive direct brain control of artificial limbs is both challenging and desirable. Such a sensory and control system, if successful, will have a profound impact on the disabled. In this dissertation, we present the design and development of a non-invasive, hybrid sensory system, which uses near-infrared spectroscopy (NIRS) and electroencephalography (EEG) to measure brain activity with simultaneous electromyography (EMG) to provide feedback data in a healthy limb. Through the combination of these sensory techniques, we have successfully trained a control system capable of mapping brain activity onto muscle actuation. The design of a control algorithm capable of automatic reconfiguration to account for changing sensor conditions, selection of an appropriate pre-trained network based on input characteristics, and adaptation to adjust output based on the user's activity are investigated. The selection of an appropriate algorithm and its initial performance using our sensory system are presented and discussed. The sensory and control system are designed for application in artificial limb control for persons who have undergone amputation of an upper-extremity. Actuation of the elbow and wrist are the primary focus of the study, with the intent to expand to forearm torsion and hand grasping in subsequent studies. During the course of the investigation, the additional function of treating phantom limb pain was incorporated into the design, which has also lead to increased sensor resolution requirements.
Globalization: The Next 25 Years (Introduction) (2018)

A warm welcome to you all. Thank you for your participation in this very special milestone for this Journal. As you know, this symposium conference marks the twenty-fifth anniversary of the journal. Our first symposium conference was entitled "The Globalization of Law, Politics and Markets." Those papers were published in our first issue. I went back to that first issue not long ago, and found these lines:\n"We currently stand at a watershed in the public law history of the United States. We have moved from local and state common-law, regulatory regimes that dominated the 19th and early 20th centuries, to national regimes that dominated the public law of the 1930s to 1980s, to the present global era. In the present era, law formulated solely in terms of purely state or national entities, without taking into account the significant role played by transnational forces embodied in multinational corporations, global capital markets, and rapidly advancing technologies and new scientific discoveries, is likely to be not only ineffective, but counterproductive. Today [1993], the line between domestic and international is largely illusory. As a result, we need fresh assessments of issues such as the role and theory of the nation-state in the twenty-first century, the need for and development of new international and global institutions, and, in particular, the kinds of domestic legal reforms necessary to mesh with or respond to global economic and political forces."\nThat was 1993. When I think about the excitement of the Journal's early days, it seems like just yesterday to me. Much has changed-our first symposium took place before NAFTA and the WTO were established. Still, some of those long-ago lines might still apply, especially in the idea of the legal academy as a place of innovation and experimentation toward the future. But as I think about the unity under law and the sure progress for the world at large, implicit in the lines I have just read, those days suddenly seem like a long time ago. Today we know, for example, that globalization is not a single process pitched toward harmonization, but something far more complex. We know it is not a unidirectional process in time or locale, a process that occurs only once, as if globalization were a straightforward yes/no question, but-again-something far more complex. As we embark upon our 25th anniversary symposium, gathered under the theme of globalization and legal studies, we have a timely opportunity to reflect on what the future world will ask of legal studies-not just in the legal profession, but across all disciplines engaged with law, and not just in the United States, but around the world. Of course, this also means thinking about the needs for and stakes in law, for ordinary people in their daily lives, around the world.
NF- B constitutes a potential therapeutic target in high-risk myelodysplastic syndrome (2005)

Myelodysplastic syndrome (MDS) is a preneoplastic condition that frequently develops into overt acute myeloid leukemia (AML). The P39 MDS/AML cell line manifested constitutive NF-kappaB activation. In this cell line, NF-kappaB inhibition by small interfering RNAs specific for p65 or chemical inhibitors including bortezomib resulted in the down-regulation of apoptosis-inhibitory NF-kappaB target genes and subsequent cell death accompanied by loss of mitochondrial transmembrane potential as well as by the mitochondrial release of the caspase activator cytochrome c and the caspase-independent death effectors endonuclease G and apoptosis-inducing factor (AIF). Bone marrow cells from high-risk MDS patients also exhibited constitutive NF-kappaB activation similar to bone marrow samples from MDS/AML patients. Purified hematopoietic stem cells (CD34+) and immature myeloid cells (CD33+) from high-risk MDS patients demonstrated the nuclear translocation of the p65 NF-kappaB subunit. The frequency of cells with nuclear p65 correlated with blast counts, apoptosis suppression, and disease progression. NF-kappaB activation was confined to those cells that carried MDS-associated cytogenetic alterations. Since NF-kappaB inhibition induced rapid apoptosis of bone marrow cells from high-risk MDS patients, we postulate that NF-kappaB activation is responsible for the progressive suppression of apoptosis affecting differentiating MDS cells and thus contributes to malignant transformation. NF-kappaB inhibition may constitute a novel therapeutic strategy if apoptosis induction of MDS stem cells is the goal.
HadoopDB in action (2010)

HadoopDB is a hybrid of MapReduce and DBMS technologies, designed to meet the growing demand of analyzing massive datasets on very large clusters of machines. Our previous work has shown that HadoopDB approaches parallel databases in performance and still yields the scalability and fault tolerance of MapReduce-based systems. In this demonstration, we focus on HadoopDB's flexible architecture and versatility with two real world application scenarios: a semantic web data application for protein sequence analysis and a business data warehousing application based on TPC-H. The demonstration offers a thorough walk-through of how to easily build applications on top of HadoopDB.
CXCR6 promotes dermal CD8 + T cell survival and transition to long-term tissue residence (2023)

Tissue resident memory T cells (T<sub>RM</sub>) provide protection against local re-infection, and yet the interstitial signals necessary for their formation and persistence remain incompletely understood. Here we show that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved adaptation to peripheral tissue infiltration that promotes T<sub>RM</sub> formation after viral infection. Deficient T<sub>RM</sub> formation in the absence of CXCR6 was not explained by canonical trafficking as CXCR6 was not required for tissue entry, was dispensable for the early accumulation of antigen-specific CD8<sup>+</sup> T cells in skin, and did not restrain their exit. Further, single cell sequencing indicated that <i>Cxcr6</i> <sup>-/-</sup> CD8<sup>+</sup> T cells were competent to acquire a transcriptional program of residence and T<sub>RM</sub> that formed were equally functional compared to their WT counterparts when reactivated greater than 100 days post primary infection. The reduced numbers observed at memory time points, where instead found to associate with impaired redox homeostasis and antioxidant capacity during the transition from effector to memory states. As such, <i>Cxcr6</i> <sup>-/-</sup> CD8<sup>+</sup> T cells exhibited increased rates of apoptosis in the dermis relative to controls, which led to reduced numbers of T<sub>RM</sub> in the epidermis at memory. CXCR6 therefore promotes the metabolic adaptation of T cells as they engage antigen in tissue to increase the probability of memory differentiation and long-term residence.
Synthesis of Poly(phenylene sulfide) by O2 Oxidative Polymerization of Methyl Phenyl Sulfide (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Poly(phenylene sulfide) by O2 Oxidative Polymerization of Methyl Phenyl SulfideEishun Tsuchida, Eiichi Shouji, Fumiaki Suzuki, and Kimihisa YamamotoCite this: Macromolecules 1994, 27, 4, 1057–1060Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ma00082a027https://doi.org/10.1021/ma00082a027research-articleACS PublicationsRequest reuse permissionsArticle Views433Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Production of Electroslag Remelted Hollow Ingots (1976)

The development of a production process for the electroslag remelting of hollow shapes has been described. ESR hollows 21 O.D. x 10 I.D. and 16 O.D. x 10 I.D. have been produced. The hot workability of both sizes was found to be excellent, based on Gleeble hot ductility studies as well as actual forging and rolling experiments. For the 21 x 10 ESR hollow, hot working studies indicate that 35% work is sufficient to develop a fully wrought structure. Initial mechanical property data are all above specification limits for the forged hollows.
Refining the Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma (2019)

Current guidelines include the use of oxaliplatin as part of adjuvant chemotherapy (AC) in patients with clinical stage II or III rectal adenocarcinoma (RAC). However, its efficacy is supported only by a single phase II trial. This study found an association with improved overall survival with the use of doublet AC in patients diagnosed with clinical stage III and subsequent pathological stage III, and not in patients with pathological stage 0 or I, regardless of their clinical stage. Therefore, omission of oxaliplatin can be considered in patients with either pathological complete response or pathological stage I RAC, thereby avoiding oxaliplatin-induced neuropathy.
Impact of Fuel Properties on the Performances and Knock Behaviour of a Downsized Turbocharged DI SI Engine - Focus on Octane Numbers and Latent Heat of Vaporization (2009)

&lt;div class="htmlview paragraph"&gt;Facing the CO&lt;sub&gt;2&lt;/sub&gt; emission reduction challenge, the combination of downsizing and turbocharging appears as one of the most promising solution for the development of high efficiency gasoline engines. In this context, as knock resistance is a major issue, limiting the performances of turbocharged downsized gasoline engines, fuel properties are more than ever key parameters to achieve high performances and low fuel consumption's levels.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper presents a combustion study carried out into the GSM consortium of fuel quality effects on the performances of a downsized turbocharged Direct Injection SI engine. The formulation of two adapted fuel matrix has allowed to separate and evaluate the impacts of three major fuel properties: Research Octane Number (RON), Motor Octane Number (MON) and Latent Heat of Vaporization (LHV).&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Engine tests were performed on a single cylinder engine at steady state operating condition. The engine corresponds to a downsized GDI SI engine with a displacement of 300cm&lt;sup&gt;3&lt;/sup&gt; and allows IMEP up to 30bar according to the engine speed. For each tested fuel, knock limitations have been evaluated at various engine speed.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Through the development of adapted methodologies for extended results analysis, contributions of RON, MON and LHV to knock resistance were isolated, evaluated and compared. This study confirms and weights the striking role of high RON values and the positive influence of the “cooling effect” linked to high LHV values. However, no clear impact of the MON was noticed.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Considering the double knock resistance action of ethanol, attention was particularly paid to ethanol blend fuels. In the case of a 20%v ethanol blend, the “cooling effect” brings from 30 to 60%, depending on engine speed, of the total knock resistance increase, compared to gasoline base fuel.&lt;/div&gt;