gebhart/patrepeval huggingface dataset:
Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis (2020)

Phenotypic characterization of T cells in myelofibrosis (MF) is intriguing owing to increased inflammation, markedly elevated pro-inflammatory cytokines, and altered distribution of T-cell subsets. Constitutive activation of Janus kinase-2 (JAK2) in the majority of MF patients contributes to the expression of the programmed cell death protein-1 (PD1) and T-cell exhaustion. We wondered whether T-cell activation affects treatment outcome of patients with MF and sought to determine whether the JAK1/2 inhibitor ruxolitinib affects the activation of T-cell subsets. T cells from 47 MF patients were analyzed and the percent of either helper (CD4+) or cytotoxic (CD8+) naive, central memory, effector memory, or effector T cells; and fractions of PD1-expressing cells in each subset were assessed. An increased number of T cells coexpressing CD4/PD1 and CD8/PD1 in MF compared to healthy controls (n=28) was found, and the T cells were significantly skewed toward an effector phenotype in both CD4+ and CD8+ subsets, consistent with a shift from a quiescent to an activated state. Over the course of ruxolitinib treatment, the distribution of aberrant T-cell subsets significantly reversed towards resting cell phenotypes. CD4+ and CD8+ subsets at baseline correlated with monocyte and platelet counts, and their PD1-positive fractions correlated with leukocyte counts and spleen size. Low numbers of PD1+/CD4+ and PD1+/CD8+ cells were associated with complete resolution of palpable splenomegaly and improved survival rate, suggesting that low levels of exhausted T cells confer a favorable response to ruxolitinib treatment.
Size Reduction of Crystals in Slurries by the Use of Crystal Habit Modifiers (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSize Reduction of Crystals in Slurries by the Use of Crystal Habit ModifiersSara Sarig and John W. MullinCite this: Ind. Eng. Chem. Process Des. Dev. 1980, 19, 3, 490–494Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/i260075a027https://doi.org/10.1021/i260075a027research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cost-effectiveness of integrated care for elderly depressed patients in the PRISM-E study. (2009)

These results suggest that general integration has its advantages and, when such integration exists, further integrating behavioral health care into primary care might be considered as one way to improve depression in elders. The finding that ESR may be cost effective in some settings is also policy relevant. Further research is needed to analyze the components of the costs of ESR in non-VA settings and the effectiveness of IC in VA settings.
On the Rates of Convergence From Surrogate Risk Minimizers to the Bayes Optimal Classifier (2021)

In classification, the use of 0-1 loss is preferable since the minimizer of 0-1 risk leads to the Bayes optimal classifier. However, due to the nonconvexity of 0-1 loss, this optimization problem is NP-hard. Therefore, many convex surrogate loss functions have been adopted. Previous works have shown that if a Bayes-risk consistent loss function is used as a surrogate, the minimizer of the empirical surrogate risk can achieve the Bayes optimal classifier as the sample size tends to infinity. Nevertheless, the comparison of convergence rates of minimizers of different empirical surrogate risks to the Bayes optimal classifier has rarely been studied. Which characterization of the surrogate loss determines its convergence rate to the Bayes optimal classifier? Can we modify the loss function to achieve a faster convergence rate? In this article, we study the convergence rates of empirical surrogate minimizers to the Bayes optimal classifier. Specifically, we introduce the notions of consistency intensity and conductivity to characterize a surrogate loss function and exploit this notion to obtain the rate of convergence from an empirical surrogate risk minimizer to the Bayes optimal classifier, enabling fair comparisons of the excess risks of different surrogate risk minimizers. The main result of this article has practical implications including: 1) showing that hinge loss (SVM) is superior to logistic loss (Logistic regression) and exponential loss (Adaboost) in the sense that its empirical minimizer converges faster to the Bayes optimal classifier and 2) guiding the design of new loss functions to speed up the convergence rate to the Bayes optimal classifier with a data-dependent loss correction method inspired by our theorems.
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial (2020)

ISRCTN15088122 , registered on 19 July 2011; NCT01402882 , registered on 26 July 2011.
Design and implementation of a novel double-poly microphone with rigid acoustic receiver, flexible spring supporter, and harm backplate (2010)

This study reports the design and implementation of a novel micromachined microphone. The design of the microphone is based on the well-known two-poly processes. The design as shown in Fig.1 has four merits, (1) rigid-diaphragm formed by the rib-reinforced poly-Si as acoustic wave receiver and moving-electrodes, (2) flexible-spring formed by thin poly-Si as diaphragm supporter, (3) rigid-diaphragm anchored to flexible-spring by central poly-via, and (4) very rigid plate formed by high-aspect-ratio (HARM) trench-refilled poly-Si as stationary-electrodes and back-plate. To demonstrate the feasibility, the two-poly microphone has been implemented and tested. Typical measurement results show that the sensitivity of microphone is 12.63 mV/Pa (-37.97 dB/Pa) measured at the sound level of 94 dB.
Using Erasure Feedback for Online Timely Updating with an Energy Harvesting Sensor (2019)

A real-time status updating system is considered, in which an energy harvesting sensor is acquiring measurements regarding some physical phenomenon and sending them to a destination through an erasure channel. The setting is online, in which energy arrives in units according to a Poisson process with unit rate, with arrival times being revealed causally over time. Energy is saved in a unit-sized battery. The sensor is notified by the destination of whether updates were erased via feedback. Updates need to reach the destination successfully in a timely fashion, namely, such that the long term average age of information, defined as the time elapsed since the latest successful update has reached the destination, is minimized. First, it is shown that the optimal status update policy has a renewal structure: successful update times should constitute a renewal process. Then, threshold-greedy policies are investigated: a new update is transmitted, following a successful one, only if the age of information grows above a certain threshold; and if it is erased, then all subsequent update attempts are greedily scheduled whenever energy is available. The optimal threshold-greedy policy is then analytically derived.
Development of Long Haul Optical Transmission Equipment for an Uncompressed 8K Super Hi-Vision Signal (2016)

ハイビジョンの中継番組制作では，光ファイバ専用線を介した非圧縮インタフェース信号の長距離伝送が行われている．そこで，将来的に非圧縮8Kスーパーハイビジョン（Super Hi-Vision: SHV）映像のインタフェース信号（Ultrahigh-definition Signal/Data Interface: U-SDI）も同様に長距離伝送できることが望ましい．大容量信号の光ファイバ伝送では，波長分散に起因するデータ誤りの発生によって伝送距離が制限される．分散補償ファイバ（Dispersion Compensation Fiber: DCF）や，前方誤り訂正（Forward Error Correction: FEC）は，大容量信号の長距離伝送におけるデータ誤りを低減する技術として有効である．そこで，本稿では，U-SDI信号にFECを付加し，DCFと併用して伝送する開発装置の詳細について述べる．さらに，開発装置を用いた173 kmの長距離フィールド伝送実験を行った結果，非圧縮SHV映像の安定伝送に成功したので報告する．
Determination of Antioxidant Properties of 26 Chilean Honeys and a Mathematical Association Study with their Volatile Profile (2012)

Radical scavenging activity (RSA), antioxidant content (TEAC), total phenolic compounds content (TPCC) and volatile profile (VOCs) were measured in 26 honeys obtained from the Valparaiso Region (Chile). Persea americana honey was the most interesting sample according to these evaluated parameters. A Projection to Latent Structures (PLS) based algorithm was used to model the possible relationship between antioxidant activity, total phenolic compounds content and volatile profile. Concerning the volatile profile, only nine volatile compounds, of a total of fifty, showed dependence on antioxidant activity and total phenolic compounds content.
Evaluation of the Image-Pro Plus 4.5 software for automatic counting of labeled nuclei by PCNA immunohistochemistry (2004)

The objective of this study was to create and evaluate a routine (macro) using Image-Pro Plus 4.5 software (Media Cybernetics, Silver Spring, USA) for automatic counting of labeled nuclei by proliferating cell nuclear antigen (PCNA) immunohistochemistry. A total of 154 digital color images were obtained from eleven sections of reticular oral lichen planus stained by PCNA immunohistochemistry. Mean density (gray-level), red density, green density, blue density, area, minor axis, perimeter rate and roundness were parameters used for PCNA labeled nuclei discrimination, followed by their outlined presentation and counting in each image by the macro. Mean density and area thresholds were automatically defined based, respectively, on mean density and mean area of PCNA labeled nuclei in the assessed image. The reference method consisted in visual counting of manually outlined labeled nuclei. Statistical analysis of macro results versus reference countings showed a very significant correlation (rs = 0.964, p < 0.001) for general results and a high level (89.8 +/- 3.8%) of correctly counted labeled nuclei. We conclude that the main parameters associated with a high correlation between macro and reference results were mean density (gray-level) and area thresholds based on image profiles; and that Image-Pro Plus 4.5 using a routine with automatic definition of mean density and area thresholds can be considered a valid alternative to visual counting of PCNA labeled nuclei.
Application of the Lifshitz-Slyozov theory to precipitation of phosphorus in silicon-germanium thermoelectric alloys (1974)

The applicability of the Lifshitz-Slyozov model for predicting phosphorus precipitation rates in the phosphorus-SiGe system is investigated. Model parameters are determined from short-term anneals of less than 2000 h for SiGe alloys varying in silicon content from 67 to 81 at.% and prepared by zone leveling or hot pressing. Using these parameters in the model, resistivity changes are predicted for phosphorus-doped SiGe thermoelectric elements which had been life tested from 4000 to 40 000 h. It is concluded that the Lifshitz-Slyozov model is applicable to the phosphorus-SiGe system. The results of this study can be used to calculate long-term degradation of thermoelectric performance in SiGe alloys due to phosphorus precipitation.
Neurocognitive Changes among Elderly Exposed to PCBs/PCDFs in Taiwan (2007)

Our study showed dose-dependent neurocognitive deficits in certain aspects of attention, visual memory, and learning ability in women previously exposed to PCBs and PCDFs, but not in exposed men.
Introduction (2011)

In a very short time the United States has realized that global warming poses real challenges to the nation’s future. The Agile City engages the fundamental question of what to do about it.
ChemInform Abstract: Anomalous Reactivity of Sodium Phenyl Selenide. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mirroring and Understanding (2023)

Abstract This chapter provides a review of the data collected over the last twenty years in support of the claim that the mirror mechanism can play a distinctive role in our understanding of other people’s actions, emotions, and vitality forms. This claim is undoubtedly the most debated of all the issues tackled in the book. For this reason, the chapter extensively discusses the main lines of evidence suggesting that the sensorimotor transformations induced by the mirror responses impact on how observed actions are perceptually judged. Similarly, it examines several studies, assessing whether and to what extent the recruitment of visceromotor representations plays a distinctive role in understanding other peoples’ emotions. The chapter closes with a review of the evidence of mirror responses for vitality form recognition.
Controlled radical polymerization of styrene by iodine transfer polymerization (ITP) in ab initio emulsion (2008)

International audience
Addendum to “Feedforward Carrier Recovery for Coherent Optical Communications” (2009)

In a previous paper , we noted when the transmitted signal constellations has rotational symmetry, laser phase noise can be mitigated using non-data-aided (NDA) feedforward (FF) carrier recovery. The structures of a FF carrier recovery unit and a NDA soft-decision phase estimator were shown in Fig. 3 and 4(a), respectively. We have found that in an NDA FF carrier recovery unit, the order of the linear filter and phase estimator can be exchanged in a manner not possible with a decision-directed (DD) FF carrier recovery unit. We show that this alternative NDA (ANDA) FF carrier recovery unit exhibits better immunity to cycle slips compared to standard NDA.
Multiple Emissions from 1,3-Diphenyl-5-pyrenyl-2-pyrazoline Nanoparticles: Evolution from Molecular to Nanoscale to Bulk Materials (2002)

Tunable, multiple emission is exhibited by nanoparticles of 1,3-diphenyl-5-pyrenyl-2-pyrazoline (DPP; see picture), which ranges from near-UV to green. Tuning could be effected by alteration of either the excitation wavelength or the nanoparticle size. In contrast, DPP in dilute solution only showed the emission characteristics of the pyrene chromophore. In bulk crystals, only the emission characteristics of the pyrazoline chromophore were exhibited.
An Overview of Biomass Pyrolysis (2002)

Abstract The pyrolysis is degradation of biomass by heat in the absence of oxygen, which results in the production of charcoal, liquid, and gaseous products. The pyrolysis process can be divided into three subclasses: conventional pyrolysis, fast pyrolysis, and flash pyrolysis. The hemicelluloses break down first at temperatures of 470 to 530 K, cellulose follows in the temperature range 510 to 620 K, and lignin is the last component to pyrolyze at temperatures of 550 to 770 K. If the purpose is to maximize the yield of liquid products resulting from biomass pyrolysis, a low temperature, high heating rate, short gas residence time process would be required. For a high char production, a low temperature, low heating rate process would be chosen. If the purpose was to maximize the yield of fuel gas resulting from pyrolysis, a high temperature, low heating rate, long gas residence time process would be preferred. Keywords: Pyrolysis Thermal Degradation Biomass Fast Pyrolysis Flash Pyrolysis
Postzygotic isolating factor in sympatric speciation in Rhagoletis flies: Reduced response of hybrids to parental host-fruit odors (2004)

Rhagoletis pomonella is a model for sympatric speciation (divergence without geographic isolation) by means of host-plant shifts. Many Rhagoletis species are known to use fruit odor as a key olfactory cue to distinguish among their respective host plants. Because Rhagoletis rendezvous on or near the unabscised fruit of their hosts to mate, behavioral preferences for fruit odor translate directly into premating reproductive isolation among flies. Here, we report that reciprocal F(1) hybrids between the apple and hawthorn host races of R. pomonella, as well as between the host races and an undescribed sibling species infesting Cornus florida (flowering dogwood) do not respond to host fruit volatiles in wind-tunnel assays at doses that elicit maximal directed flight in parental flies. The reduced ability of hybrids to orient to fruit volatiles could result from a conflict between neural pathways for preference and avoidance behaviors, and it suggests that hybrids might suffer a fitness disadvantage for finding fruit in nature. Therefore, host-specific mating may play a dual role as an important postzygotic as well as a premating reproductive barrier to isolate sympatric Rhagoletis flies.
Free Vibration Analysis of Double Curvature Thin Walled Structures by a B-Spline Finite Element Approach (2007)

This paper presents a free vibration analysis of general double curvature shell structures using B-spline shape functions and a refinement technique. The shell formulation is developed following the well known Ahmad degenerate approach including the effect of the shear deformation. The formulation is not isoparametric, as a consequence the assumed displacement field is described through non-uniform B-spline functions of any degree. A solution refinement technique is considered by means of a high continuity p-method approach. The eigensolution of a plate, and of single and double curvature shells are obtained by numerical simulation to test the performance of the approach. Solutions are compared with other available analytical and numerical solutions, and discussion follows.
Development, evaluation, and in-vivo validation of two non-invasive methods for quantitation of activity and dosimetry of monoclonal antibodies in humans (1985)

The authors have applied both a conjugate view imaging method and a first pass study for quantitation of absolute I-131 activity in lesions and normal tissue of patients with colon carcinoma in order to study biological clearance of the I-131 F(ab)'/sub 2/ fragments of mouse monoclonal antibody and the resultant dosimetry. Both methods require a transmission scan for determining patient attenuation and measurement of patient lesion or organ size in the region of interest. The conjugate view method is analyzed for both SPECT and planar imaging. The percent error of both methods relates to lesion size and absolute activity when compared to actual well-counter assayed samples of malignant and normal tissue obtained from CT-guided needle biopsies or surgical specimens. Dosimetric evaluation was based on determination of activity, clearance from computer-generated time-activity curves and lesion or organ volumes from volumetric CT scan data. The dose to the thyroid gland was calculated for one population receiving Lugol's solution 3 days prior and for the other who received Lugol's at the time of administration. Data showed no significant difference in absorbed thyroid dose. Lastly, the absolute uptake of I-131, lesion to background ratios, and the dosimetry data were compared for three different monoclonalmore » antibody fragments.« less
Application of hybrid heating textile structures in clothing for seniors (2018)

Active integral electronic elements in smart clothes can increase the utility value of the garment and the user's comfort. This article is primarily focuses on the comfort of clothing designed especially for the elderly, or people with impaired thermoregulatory capabilities. The research part is focuses on the possibilities of increasing clothing comfort of application a smart electronic textile element into garments. ft deals especially with the possibilities of application of electric heating built directly into clothing for seniors, especially for clothes designed for cold environment. The proposed heating system based on embroidery with using hybrid threads can be use especially in winter clothing, but can also be used for home-use clothing or everywhere it is disadvantageous or inappropriately to increase the ambient temperature. The main goal is to improve physiological comfort and ensure thermal comfort in the winter months. From the textile point of view, it is important to ensure that the integration of the heating structure into the garment in order to fulfil its function as best as possible and allow the normal maintenance of the garment by the user and have no impair to the physiological comfort and other utility properties which are also important for the garment. fn the case of seniors, the electronics must contain safety features to prevent tampering and avoid the risk of injury to the user. The textile part must therefore comply with both the textile and maintenance requirements as well as the electrical properties. When using active elements in clothing, we need to address the issue of safety, routine clothing maintenance, battery placement, electronics interconnection, durability and other aspects of textile and electronic character. This paper describes the possibilities of creating heating elements using an embroidery machine and the possibility of their integration into selected types of clothing. A practical example then demonstrates the use of hybrid threads that are applied by embroidering the heating structure directly onto a suitable textile backing, demonstrating their potential for increasing the utility properties of the garment.
Control of a ground vehicle using quadratic programming based control allocation techniques (2004)

This paper examines the use of control allocation techniques for the control of multiple inputs to a ground vehicle to track a desired yaw rate trajectory while minimizing vehicle sideslip. The proposed controller uses quadratic programming accompanied by linear quadratic regulator gains designed around a linear vehicle model to arrive at a combination of vehicle commands. Several failure scenarios are examined and the results for two different quadratic programming approaches are presented along with a discussion of the advantages each method has to offer.
A 10.7b 300MS/s Two-Step Digital-Slope ADC in 65nm CMOS (2020)

This article describes a 10.7b 300MS/s two-step digital-slope analog-to-digital converter using an on-chip digital-offset correction. The proposed two-step digital-slope ADC is implemented using a passive track-and-hold followed by the input-polarity comparison and the two-step digital-slope conversion. The polarity of the input signal must be determined to control the level-shifting process and specify the operation polarity of the two-step digital-slope conversion. Besides, the two-step digital-slope conversion shares the unary DAC with different weights, which not only mitigates the resolution issues of the digital-slope quantizer but also converts the residue without requiring gain-error calibration. The two-step digital-slope ADC can be divided into three conversion steps and provide 1-bit, 5.7-bit, and 4-bit resolution for each conversion cycle. The digital-offset correction then encodes the three sets of outputs and subtracts the digital-offset caused by the feedback-process latency of the quantizers. The proposed two-step digital-slope ADC is manufactured using 1P9M 65-nm CMOS technology, and the active area of the prototype is 0.0946 square millimeter. At the Nyquist frequency, the SNDR and SFDR measured at 1.2 V, and 300 MS/s are 60.72 dB and 70.05 dB, respectively. With the power consumption of 6.2mW, the corresponding Walden FoM is 23.3 fJ/conversion-step.