gebhart/patrepeval huggingface dataset:
MR Imaging–guided Prostate Biopsy with a Closed MR Unit at 1.5 T: Initial Results (2005)

The authors evaluated a magnetic resonance (MR) imaging-compatible biopsy device comprising a needle guide that can be visualized with MR imaging and manipulated mechanically from outside the MR unit. With approval from the local ethics committee and patient consent, this device was tested in 12 patients by using a closed 1.5-T MR unit and a body phased-array coil. Patients had elevated prostate-specific antigen levels (6-60 ng/mL) and one or more areas in the prostate that were suspicious for carcinoma at prebiopsy MR imaging. Biopsy was performed with transrectal access and with the patient prone. A 16-gauge MR imaging-compatible needle was successfully positioned with the device, and between six and nine tissue cores were obtained in each patient. In one patient, two suspicious basal areas could not be reached with the device. Histologic analysis showed prostate cancer in five patients and prostatitis in six. No complications were observed. The device enabled MR imaging-guided core-needle biopsy of prostate areas suspicious for cancer on MR images.
Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems (2018)

ABSTRACT The gene mutated in Huntington’s disease (HD) patients encodes the 348 kDa huntingtin (HTT) protein. The pathogenic HD CAG-expansion mutation causes a polyglutamine (polyQ) tract at the N-terminus of the HTT protein to expand above a critical threshold of ~35 glutamine residues. The effect of HD mutations on HTT is not well understood, in part due to difficulties in carrying out biochemical, biophysical and structural studies of this large protein. To facilitate such studies, we have generated expression constructs for the scalable production of HTT in multiple eukaryotic expression systems. Our set of HTT expression clones comprises both N and C-terminally FLAG-tagged HTT constructs with polyQ lengths representative of the general population, HD patients, juvenile HD patients as well as the more extreme polyQ expansions used in some HD tissue and animal models. These reagents yield milligram quantities of pure recombinant HTT protein, including many of the previously mapped posttranslational modifications. We have characterised both apo and HTT-HAP40 complex samples produced using this HD resource, demonstrating that this toolkit can be used to generate physiologically meaningful complexes of HTT. We demonstrate how these resources can produce sufficient material for protein-intensive experiments such as small angle X-ray scattering (SAXS), providing biochemical insight into HTT protein structure. The work outlined in this manuscript and the tools generated, lay a foundation for further biochemical and structural work on the HTT protein and its functional interactions with other biomolecules.
Learning how to grasp under supervision (1992)

The problem of grasping a generic sphere is addressed. A supervised learning approach using a multilayer neural network for learning the position in 3D space and the radius of the sphere is introduced. Learning is based on laser range finder measurements of the surface of spheres of known radii at known positions. The problem is first formulated. An analytical solution for a set of four laser range finders and a solution based on supervised learning are then given and compared. Experimental results showing the feasibility and novelty of the approach are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Linear tuning of the resonant frequency in tilting oscillators by an axially loaded suspension flexure (2008)

In this work we present a novel approach for fine linear tuning of resonant frequency in tilting oscillators and investigate, both theoretically and experimentally, the main features and functionality of the tuning mechanism. The operation principle of the tuning mechanism is based on the application of an axial force to a cantilever-like suspension flexure, built in such a way that the real pivot is replaced by a virtual one, which provides a center of rotation. The axial force is provided by an electrostatic transducer realized in the framework of the single layer multiple close-gap electrodes actuation concept. Devices with three different types of suspensions were fabricated and characterized. Experimental and theoretical results collectively show that the suggested approach can be efficiently implemented for resonant frequency tuning in tilting devices.
Losartan vs Atenolol in Prevention of Stroke and Cardiovascular Disease (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse Effects of Pine Needles on Aspects of Digestive Performance in Cattle (1992)

James A. Pfister, Don C. Adams, Randall D. Wiedmeier, Rex G. Cates, Adverse Effects of Pine Needles on Aspects of Digestive Performance in Cattle, Journal of Range Management, Vol. 45, No. 6 (Nov., 1992), pp. 528-533
Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms. (1987)

We treated 103 patients with histologically confirmed anaplastic supratentorial astrocytic neoplasms with either diaziquone (AZQ) and carmustine (BCNU) or AZQ and procarbazine. There were 74 patients with glioblastoma multiforme (GBM) and 29 patients with anaplastic astrocytoma (AA). AZQ plus BCNU produced partial (PR) or unequivocal responses in seven of 32 (21.9%) patients with GBMs and three of ten (30%) patients with AAs. Two patients with GBMs (6.3%) and five patients with AAs (50%) showed stable disease (SD). AZQ plus procarbazine produced PRs or unequivocal responses in five of 42 (11.9%) patients with GBMs and nine of 19 (47.4%) patients with AAs. Eight patients with GBMs (19%) and one patient with an AA (5.2%) showed SD. In addition to histologic diagnosis, only the Karnofsky performance-status (KPS) rating independently influenced response and survival. Differences in response rates between the two regimens were not significant, although estimated median survival after adjusting for performance status was slightly better with AZQ plus BCNU than with AZQ plus procarbazine (P = .031). Neither age nor prior chemotherapy were significant independent risk factors. Toxicity was mild and primarily hematologic. We conclude that these AZQ-based regimens have activity in patients with recurrent anaplastic gliomas, but that they are not clearly superior to other agents in current use. The histologic diagnosis of GBM is associated with a significantly worse prognosis than AA, and we believe that this important distinction must be recognized in phase II as well as phase III trials.
Interleukin 6 in Hyposmia (2013)

Compared with controls, IL-6 in patients was significantly elevated in plasma, saliva, and nasal mucus. Because IL-6 is a proinflammatory cytokine, these changes can relate to local or systemic inflammatory processes, which can be a cause or a result of pathological processes associated with hyposmia. These results support the concept that hyposmia has a biochemical basis and IL-6 may play a role in biochemical pathological processes underlying hyposmia and its treatment.
Development of Novel, Highly Cytotoxic Fusion Constructs Containing Granzyme B: Unique Mechanisms and Functions (2009)

Recombinant fusion proteins are an expanding, important class of novel therapeutic agents. The designs of these constructs typically involve a cell-targeting motif genetically fused to a highly toxic class of enzymes capable of ruthlessly attacking critical cellular machinery once delivered successfully to the cytoplasm of the target cell. Initial development of this class of constructs typically contained recombinant growth factors or single-chain antibodies as the cell-targeting motif fused to highly cytotoxic plant or bacterial toxins. This review describes second-generation molecules composed of cell-targeting molecules fused to highly cytotoxic human enzymes capable of generating intense apoptotic response once delivered to the cytoplasm. The human serine protease granzyme B has been shown to be extremely effective as a cytotoxic molecule when incorporated into numerous cell-targeting constructs. The biological activity of GrB-containing constructs rivals that of plant or bacterial toxins and appears to represent a new generation and class of completely human proteins with unique biological activities.
Cluster-Based Multi-Dimensional Visualization (2011)

There is a growing need for high-frame-rate low-latency visualization solutions as medical practice moves toward interventional procedures. We present a cost-effective visualization system well suited for off-line visualization and interventional procedures. Users can view large time-resolved multi-dimensional datasets in real time with GPU cluster visualization. In addition, computational pre-processing can be hidden by rendering across distributed graphics cards, leading to improved frame-rates over a single graphics card solution. Finally, rendering on graphics cards offloads CPU cycles for generating the next time frame in the visualization. We have developed a network arbitration protocol for GPU cluster visualization called “token scheduling.” Our protocol reduces communication latency, which in turn lowers visualization latency and improves system stability and scalability. In addition, we evaluate GPU cluster behavior and performance through a timing analysis. This analysis leads to a better understanding of cluster size needed to achieve the desired frame rate of a given problem.
Supplemental Figure 4 from MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer (2023)

&lt;p&gt;R3Mab reduces MMP protein secretion in the conditioned medium by UMUC-14 cells.&lt;/p&gt;
Direct mode coding for bipredictive slices in the H.264 standard (2005)

The new H.264 (MPEG-4 AVC) video coding standard can achieve considerably higher coding efficiency compared to previous standards. This is accomplished mainly due to the consideration of variable block sizes for motion compensation, multiple reference frames, intra prediction, but also due to better exploitation of the spatiotemporal correlation that may exist between adjacent Macroblocks, with the SKIP mode in predictive (P) slices and the two DIRECT modes in bipredictive (B) slices. These modes, when signaled, could in effect represent the motion of a macroblock (MB) or block without having to transmit any additional motion information required by other inter-MB types. This property also allows these modes to be highly compressible especially due to the consideration of run length coding strategies. Although spatial correlation of motion vectors from adjacent MBs is used for SKIP mode to predict its motion parameters, until recently, DIRECT mode considered only temporal correlation of adjacent pictures. In this letter, we introduce alternative methods for the generation of the motion information for the DIRECT mode using spatial or combined spatiotemporal correlation. Considering that temporal correlation requires that the motion and timestamp information from previous pictures are available in both the encoder and decoder, it is shown that our spatial-only method can reduce or eliminate such requirements while, at the same time, achieving similar performance. The combined methods, on the other hand, by jointly exploiting spatial and temporal correlation either at the MB or slice/picture level, can achieve even higher coding efficiency. Finally, improvements on the existing Rate Distortion Optimization related to B slices within the H.264 codec are also presented, which can lead to improvements of up to 16% in bit rate reduction or, equivalently, more than 0.7 dB in PSNR.
Effects of TiC content and grain size on cutting performance of Al2O3-TiC ceramics tool. (1990)

The Al2O3-TiC ceramics tools having 10-50 mass% TiC and different grain size were prepared by hot-pressing and the cutting performance of the tools were studied. The results obtained were briefly summarized as follows; The flank wear in turning tests of grey cast iron became smaller with decreasing TiC content and coarser TiC grain size, and that in the tests of ductile cast iron became smaller with increasing TiC content in no relation to TiC grain size. The tool having 20-30 mass%TiC and finer TiC grain size showed a superior resistance to flaking and an optimum cutting performance in turning test of alloyed tool steel. Discussion on flaking mechanism and the flank wear being different according to the kinds of works was given.
Competition Between Resonant Plasmonic Coupling and Electrostatic Interaction in Reduced Graphene Oxide Quantum Dots (2016)

The light emission from reduced graphene oxide quantum dots (rGO-QDs) exhibit a significant enhancement in photoluminescence (PL) due to localized surface plasmon (LSP) interactions. Silver and gold nanoparticles (NPs) coupled to rGO nanoparticles exhibit the effect of resonant LSP coupling on the emission processes. Enhancement of the radiative recombination rate in the presence of Ag-NPs induced LSP tuned to the emission energy results in a four-fold increase in PL intensity. The localized field due to the resonantly coupled LSP modes induces n-π* transitions that are not observed in the absence of the resonant interaction of the plasmons with the excitons. An increase in the density of the Ag-NPs result in a detuning of the LSP energy from the emission energy of the nanoparticles. The detuning is due to the cumulative effect of the red-shift in the LSP energy and the electrostatic field induced blue shift in the PL energy of the rGO-QDs. The detuning quenches the PL emission from rGO-QDs at higher concentration of Ag NPs due to non-dissipative effects unlike plasmon induced Joule heating that occurs under resonance conditions. An increase in Au nanoparticles concentration results in an enhancement of PL emission due to electrostatic image charge effect.
Restoring T Cell Homeostasis After Allogeneic Stem Cell Transplantation; Principal Limitations and Future Challenges (2018)

For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is the unique therapeutic modality that could potentially cure their disease. Despite significant progress made in clinical management of allogeneic-SCT, acute graft-versus-host disease (aGVHD) and infectious complications remain the second and third cause of death after disease recurrence. Clinical options to restore immunocompetence after allogeneic-SCT are very limited as studies have raised awareness about the safety with regards to graft-versus-host disease (GVHD). Preclinical works are now focusing on strategies to improve thymic functions and to restore the peripheral niche that have been damaged by alloreactive T cells. In this mini review, we will provide a brief overview about the adverse effects of GVHD on the thymus and the peripheral niche and the resulting negative outcome on peripheral T cell homeostasis. Finally, we will discuss the potential relevance of coordinating our studies on thymic rejuvenation and improvement of the peripheral lymphoid niche to achieve optimal T cell regeneration in GVHD patients.
Efficient high-power UV generation by use of a resonant ring driven by a cw mode-locked IR laser (1993)

We use a single cavity in which the second harmonic is resonant to first double and then quadruple the IR input. The cavity is powered by a 15-W cw mode-locked Nd:YLF laser. We generate intermittent 263-nm average powers as high as 6.7 W for ηIR→UV = 45%. Absorption of 527-nm radiation in the β-barium borate crystal degrades the performance during continuous operation. The highest continuous average UV power produced is 2.9 W (simultaneously; 3.6 W of 527-nm light is output).
Plasmon Resonant Silica-Coated Silver Nanoplates as Contrast Agents for Optical Coherence Tomography (2016)

Silica-coated silver nanostructures are identified as potential contrast agents for visible and near-infrared bio-imaging applications due to their high optical extinction caused by localized surface plasmon resonance (LSPR), improved chemical stability, and lower toxicity. We demonstrate the potential of plasmon resonant silica-coated silver nanoplates as a contrast agent for optical coherence tomography (OCT). It is shown that, triangular-shaped silica-coated silver nanoplates (SSNPs) with a side length of 170 ± 5 nm, base silver thickness of 10 ± 1 nm, and silica shell thickness of 40 ± 2 nm, exhibit higher optical extinction at a 1300 nm wavelength range, thus making them an excellent contrast agent for OCT imaging. Optical extinction characterization using OCT is found to be reasonably consistent with ultraviolet (UV)-Vis-near infrared (NIR) spectroscopy and finite difference time-domain (FDTD)-based analysis. Ex vivo studies on pig adipose tissue demonstrate that LSPR-induced enhanced scattering in SSNPs contributes to the OCT signal, leading to images with better contrast. Moreover, average A-scan profiles acquired at different time delays show the downward propagation of SSNPs and the extension of signal enhancement at the deeper regions. Speckle variance OCT images show that SSNPs are efficiently distributed over the targeted tissue region, demonstrating their applicability in a large lesion area.
Impact of spontaneous anti-Stokes Raman scattering on QKD+DWDM networking (2004)

This study presents an experimental demonstration of 1310 nm QKD multiplexing and transmission with amplified DWDM signals over a shared 10 km fiber span. This work identifies anti-Stokes Raman scattering generated during fiber propagation as the primary contributor of crosstalk noise at the QKD receiver. New results are presented on the characterization of spontaneous anti-Stokes Raman noise (SASRN), generated within the fiber by the high-power DWDM signals, and implications for QKD+DWDM networking architectures are also discussed.
Enhanced pitting resistance of directed energy deposition 316L stainless steel by post-manufacturing heat treatment (2022)

Abstract The effect of the post-manufacturing heat treatment (PMHT) on the pitting resistance of the directed energy deposition (DED) 316L stainless steel was evaluated. In an as-manufactured DED 316L, a fully austenitic microstructure with typical cellular structure and large columnar grains was observed. The cellular structure was retained after the PMHT of 850 °C/2 h but fully removed by the PMHT of 1150 °C/1 h, while large columnar grains survived in both cases. Both PHMTs significantly improved the pitting resistance of the DED 316L. Especially, the pitting potential of the DED 316L after the PMHT of 1150 °C/1 h was comparable to that of 2205 duplex stainless steel. The excellent pitting resistance of DED 316L after the PMHT of 1150 °C/1 h was caused by the reduction of residual stress, elimination of cellular structure, and presence of large columnar grains.
Recycling Of Plastics In Automobile Shredder Residue (2005)

Argonne National Laboratory has been conducting experiments to recover some of the plastics in the auto shredder residue (ASR) for recycling into the plastics manufacturing stream. As part of the study, we also reviewed the literature related to the disposal and handling of ASR. The results indicate that using solvents to extract individual thermo-plastics or mixtures from ASR is technically feasible. The economic competitiveness of the process depends on many factors, including the cost of disposal, how the individual plastics affect the disposal method and cost, and the market value of the recovered plastics. We present the results obtained so far and the integrated treatment and disposal procedures that are compatible with the needs of industry.
Total Synthesis of rac‐Silandrin, an Antihepatotoxic Flavanolignan (1993)

Abstract The first synthesis of racemic silandrin ( rac ‐ 1 ), which shows significant antihepatotoxic activity, has been accomplished via the key intermediate 9 prepared from the readily available starting materials caffeic acid ethyl ester ( 4 ) and coniferyl alcohol ( 5 ).
Generation of Orbital Angular Momentum Beam Using Fiber-to-Fiber Butt Coupling (2018)

We experimentally demonstrate a simple scheme for broadband generation of orbital angular momentum (OAM) using a fiber-based structure. A standard single-mode fiber (SMF) is stuck to a two-mode fiber (TMF) with specific offsets and tilt angles to realize high-order fiber mode conversion. By adjusting the polarization controllers implemented on the SMF and TWF accompanied with a polarizer filter, one can selectively obtain LP11 mode or OAM modes with l = ±1 at the output end of the TMF. We show the high-purity (extinction ratio >20 dB) generation of OAM modes within a wide range from 1480 to 1640 nm.
Colloid Probe AFM Investigation of Interactions between Fibrinogen and PEG-Like Plasma Polymer Surfaces (2005)

Interaction forces between surfaces designed to be protein resistant and fibrinogen (Fg) were investigated in phosphate-buffered saline with colloid probe atomic force microscopy. The surfaces of the silica probes were coated with a layer of fibrinogen molecules by adsorption from the buffer. The technique of low-power, pulsed AC plasma polymerization was used to make poly(ethylene glycol) (PEG)-like coatings on poly(ethylene teraphthalate) by using diethylene glycol vinyl ether as the monomer gas. The degree of PEG-like nature of the films was controlled by use of a different effective plasma power in the chamber for each coating, ranging from 0.6 to 3.6 W. This produced a series of thin films with a different number of ether carbons, as assessed by X-ray photoelectron spectroscopy. The interaction force measurements are discussed in relation to trends observed in the reduction of fibrinogen adsorption, as determined quantitatively by (125)I radio-labeling. The plasma polymer coatings with the greatest protein-repelling properties were the most PEG-like in nature and showed the strongest repulsion in interaction force measurements with the fibrinogen-coated probe. Once forced into contact, all the surfaces showed increased adhesion with the protein layer on the probe, and the strength and extension length of adhesion was dependent on both the applied load and the plasma polymer surface chemistry. When the medium was changed from buffer to water, the adhesion after contact was eliminated and only appeared at much higher loads. This indicates that the structure of the fibrinogen molecules on the probe is changed from an extended conformation in buffer to a flat conformation in water, with the former state allowing for stronger interaction with the polymer chains on the surface. These experiments underline the utility of aqueous surface force measurements toward understanding protein-surface interactions, and developing nonfouling surfaces that confer a steric barrier against protein adsorption.