gebhart/patrepeval huggingface dataset:
Calibration transfer across near infrared spectrometers for measuring hematocrit in the blood of grazing cattle (2017)

For fast diagnosis of anemia for cattle farmed on pastures, portable short wavelength near infrared spectrometer instrument was built, and the feasibility of estimating hematocrit by partial least squares regression modeling was validated in our previous work. As a follow-up, the present study reports calibration transfer from one master instrument to two slave instruments. Different approaches, i.e. making robust models, skew and bias correction, and piecewise direct standardization, were compared. Our results show that making more use of simple models based on appropriate preprocessing, number of latent variables, and wavelength selection, can sometimes be as effective as applying standardization algorithm (e.g. piecewise direct standardization) when tackling the spectral differences between instruments. The importance of a robust model during the process of calibration transfer is shown. Application of standardization such as piecewise direct standardization could be risky when the model to be transferred is not robust enough.
Dynamical observation of electrode shape in high-current, single discharge : Effects of machining atmosphere (2004)

Self-sharpening phenomena of thin tungsten electrodes in single, high current discharge have been studied by a stroboscopic imaging technique using a fast pulse laser. The diameter of sharpened electrodes depends on discharge duration even though the total discharge energy is kept constant. Effects of four types of machining atmosphere are examined: discharge in working-oil, discharge with working-oil film, discharge in argon gas and discharge in air. The optimal discharge conditions for self-sharpening vary with machining atmosphere. The self-sharpening in argon and air are found to be induced by discharge with higher current.
Real-time testing of a battery energy storage controller for harbour area smart grid: A case study for Vaasa harbour grid (2022)

Battery energy storage system makes seaport microgrids more reliable, flexible, and resilient. However, it is necessary to develop, test, and validate the functionality of battery energy storage controller in such a way that it balances power mismatch of demand and supply by charging and discharging the battery. This paper examines the performance of battery energy storage controller (BESC) to be employed in harbour grids in such a way that mismatch of power supply and load demand is compensated by charging and discharging the battery energy storage system. This controller can save energy efficiently and shave peak load demand in harbour grids where transmission and distribution systems have a limited power capacity. The controller of battery energy storage system is first developed offline in the MATLAB/Simulink, and then implemented with IEC61850 communication protocol for publishing and subscribing GOOSE messages. Moreover, to test the effectiveness of the proposed control algorithm of battery energy storage system, a real data from the local distribution system operator Vaasan Sähköverkko and harbour operator Kvarken port of Vaasa has been implemented. The simulation results show that the designed battery energy storage controller can balance power inside microgrid by charging and discharging of battery storage. The applied technique used in this paper is useful to validate the controller functionality in real time with the concept of simulation-in-loop (SIL), which is a practical approach, and it provides a cost-effective way to observe the performance of the controller.
CAVITARY CHOROIDAL NEVUS: A CASE REPORT (2020)

Benign pigmented choroidal lesions can show internal cavitations likely secondary to internal necrosis. This feature does not represent a sign of malignancy of the lesion. Enhanced depth imaging optical coherence tomography is a feasible imaging tool for the visualization of the internal cavitations and to follow their evolution over time.
ACADÉMICO DE LA UNIVERSIDAD DE BARCELONA, EN LA C TEDRA JOAQUÍN XIRAU (2011)

EN ASUNTOS POLITICOS, LAS RESPONSABILIDADES SON DE DIFERENTE GRADO Y CON PAPELES DE GRAN IMPORTANCIA, DIJO EN LA UNAM MANUEL CRUZ, INVITADO A LA C TEDRA JOAQUIN XIRAU, A CARGO DEL INSTITUTO DE INVESTIGACIONES FILOSOFICAS (IIF). EL CATEDR TICO DE LA UNIVERSIDAD DE BARCELONA HABLO EN LA SALA JOS‚ GAOS SOBRE LA DISTINCION ENTRE UNIVERSALISMO Y PLURALISMO. EL PRIMERO, EXPUSO, SE BASA EN VALORES FUNDACIONALES, MIENTRAS QUE EL SEGUNDO, EN AQUELLOS QUE CONFORMAN LA VIDA EN COM£N, COMO EL RESPETO, DECENCIA, RECHAZO DE TODA HUMILLACION, VOLUNTAD DE COMBATIR CUALQUIER FORMA DE CRUELDAD Y TOLERANCIA, ENTRE OTROS. DEL CONFLICTO DE LA RESPONSABILIDAD, SENALO LA DIFERENCIA ENTRE VALORES POSITIVOS, LOS QUE HABITUALMENTE SON RECHAZADOS PARA LA VIDA EN COM£N. PREFERIMOS QUE LAS RELACIONES PERSONALES EST‚N AMASADAS DE VINCULOS AFECTIVOS POSITIVOS, COMO LA AMISTAD E INCLUSO EL AMOR, CONTRA EL RENCOR, ODIO Y RESENTIMIENTO. ES UN ACUERDO PR CTICO. SOBRE EL MISMO ASUNTO, MANUEL CRUZ AGREGO EN CUANTO AL CONCEPTO DE RESPONSABILIDAD, QUE F CILMENTE PODRIAMOS PONERNOS DE ACUERDO EN SI LAS RAZONES TUVIERAN QUE SER SOLO ABSTRACTAS O FILOSOFICAS. DE SER ASI, ES PROBABLE QUE HUBIERA DISCREPANCIAS, COMO LA CULPA, CON AROMA ODIOSAMENTE JUDEO-CRISTIANO. LA C TEDRA JOAQUIN XIRAU, EXPLICO HECTOR SUBIRATS, DE LA FUNDACION IBEROUNAM, SE CREO EN HONOR DE QUIEN POR MUCHOS ANOS DIO CLASES EN ESTA CASA DE ESTUDIOS, PADRE DEL RECONOCIDO RAMON XIRAU. CON ANTERIORIDAD HAN PARTICIPADO EN LA MISMA PERSONALIDADES COMO MARGO GLANTZ, LUIS VILLORO, CARLOS PEREDA Y ROGER BARTRA.
Cell-free fat extract accelerates diabetic wound healing in db/db mice. (2020)

Cell-free fat extract (CEFFE), the liquid fraction derived from fat tissues, is enriched with a variety of growth factors and possesses pro-angiogenic, anti-apoptotic, and anti-oxidative properties. The aim of this study was to determine if CEFFE could accelerate chronic wound healing in mice with diabetes and investigate its underlying mechanisms. A model of circular full-thickness wound (6 mm diameter) was produced in the central dorsal region of spontaneous type 2 diabetes mellitus db/db mice. The mice were divided to three groups depending on dosage of CEFFE administered for the study; high dose CEFFE group (CEFFE<sup>high</sup>; administered 2.5 ml/kg/day via subcutaneous injection for six days), low dose CEFFE group (CEFFE<sup>low</sup>; administered 2.5 ml/kg/day via subcutaneous injection for three days), and a control group receiving phosphate buffer solution. Wound closure was evaluated on day 3, 7, 10, and 14 post-operation. Histological analyses, including hematoxylin-eosin staining and Masson's trichrome staining and immunohistological staining of anti-CD31 and anti-CD68, were also performed. Moreover, the effects of CEFFE on proliferation, migration, and tube formation of human immortal keratinocyte cells (HaCaT) and human vascular endothelial cells (HUVEC) were tested <i>in vitro</i>. The results showed that the local injection of CEFFE significantly accelerated wound healing in mice with diabetes. CEFFE improved re-epithelization and collagen secretion, promoted angiogenesis, and inhibited inflammatory macrophage infiltration <i>in vivo</i>. CEFFE also promoted HaCaT proliferation and migration and enhanced tubular formation in cultured HUVEC. It was concluded that CEFFE accelerates wound healing through pro-angiogenic and anti-inflammatory activities.
Computer Simulations of Human Neck Loads in a Car Equipped With an Airbag (1998)

Abstract It has been shown that driver fatalities in frontal collisions were reduced by 28% in airbag-equipped cars based on comparisons with similar cars equipped with manual lap/shoulder belts only (Zador and Ciccone, 1991). A similar finding was reported by the Department of Transportation that driver fatality rates in airbag equipped cars were reduced by 31% in purely frontal crashes (12:00 point of impact on the vehicle), and 19% in all frontal crashes (10:00 to 2:00). About 10% of drivers of vehicles with airbags involved in accidents received moderate to severe injuries. Most, if not all, of these people would have been more seriously injured or killed without the airbag. In a recent report to Congress, NHTSA estimated that airbags have saved 1,198 lives from 1987 through 1995, including 475 lives saved in 1995 alone.
Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis (2012)

Experimental autoimmune encephalomyelitis (EAE) is an animal model of autoimmune disease that presents with pathological and clinical features similar to those of multiple sclerosis (MS) including inflammation and neurodegeneration. This study investigated whether blueberries, which possess immunomodulatory, anti-inflammatory, and neuroprotective properties, could provide protection in EAE. Dietary supplementation with 1% whole, freeze-dried blueberries reduced disease incidence by >50% in a chronic EAE model (p < 0.01). When blueberry-fed mice with EAE were compared with control-fed mice with EAE, blueberry-fed mice had significantly lower motor disability scores (p = 0.03) as well as significantly greater myelin preservation in the lumbar spinal cord (p = 0.04). In a relapsing-remitting EAE model, blueberry-supplemented mice showed improved cumulative and final motor scores compared to control diet-fed mice (p = 0.01 and 0.03, respectively). These data demonstrate that blueberry supplementation is beneficial in multiple EAE models, suggesting that blueberries, which are easily administered orally and well-tolerated, may provide benefit to MS patients.
A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion (2022)

Membrane fusion during the entry of herpesviruses is carried out by the viral fusogen gB that is activated by its partner protein gH in some manner. The fusogenic activity of gB is controlled by its cytoplasmic (or intraviral) domain (gBCTD) and, according to the current model, the gBCTD is a trimeric, inhibitory clamp that restrains gB in the prefusion conformation. But how the gBCTD clamp is released by gH is unclear. Here, we identified two new regulatory elements within gB and gH from the prototypical herpes simplex virus 1: a surface pocket within the gBCTD and residue V831 within the gH cytoplasmic tail. Mutagenesis and structural modeling suggest that gH V831 interacts with the gB pocket. The gB pocket is located above the interface between adjacent protomers, and we hypothesize that insertion of the gH V831 wedge into the pocket serves to push the protomers apart, which releases the inhibitory clamp. In this manner, gH activates the fusogenic activity of gB. Both gB and gH are conserved across all herpesviruses, and this activation mechanism could be used by other gB homologs. Our proposed mechanism emphasizes a central role for the cytoplasmic regions in regulating the activity of a viral fusogen.
Example-based elastic materials (2011)

We propose an example-based approach for simulating complex elastic material behavior. Supplied with a few poses that characterize a given object, our system starts by constructing a space of prefered deformations by means of interpolation. During simulation, this example manifold then acts as an additional elastic attractor that guides the object towards its space of prefered shapes. Added on top of existing solid simulation codes, this example potential effectively allows us to implement inhomogeneous and anisotropic materials in a direct and intuitive way. Due to its example-based interface, our method promotes an art-directed approach to solid simulation, which we exemplify on a set of practical examples.
Effects of pressure and isotopic substitution on the Raman spectrum of α-Fe2O3: Identification of two-magnon scattering (1990)

We report measurements of the effects of high pressure and O-isotope substitution on the Raman spectrum of \ensuremath{\alpha}-${\mathrm{Fe}}_{2}$${\mathrm{O}}_{3}$. Spectra for the pressure effects were obtained from single crystals in a diamond-anvil cell; those for isotopic substitution from polycrystalline films grown in a controlled atmosphere. The Gr\"uneisen parameters and isotope shifts of the first-order phonons are found to be comparable to the same quantities for the strong 1320-${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ line, consistent with its assignment by McCarty [Solid State Commun. 68, 799 (1988)] as a phonon overtone. We identify the two-magnon scattering as a weak and broad feature at \ensuremath{\sim}1525 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, showing a temperature dependence consistent with a magnetic origin. As expected, the magnon peak does not shift with isotopic substitution, and its frequency is in good agreement with that predicted by an Ising-model calculation (1540 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$).
Free Radical Additions Involving Fluorine Compounds. V. Reactions of 1,2-Dibromo-2-chloro- and 1,2-Dichloro-2-iodo-1,1,2-trifluoroethane with Fluoroölefins1 (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree Radical Additions Involving Fluorine Compounds. V. Reactions of 1,2-Dibromo-2-chloro- and 1,2-Dichloro-2-iodo-1,1,2-trifluoroethane with Fluoroölefins1Paul Tarrant and Marvin R. LilyquistCite this: J. Am. Chem. Soc. 1955, 77, 13, 3640–3642Publication Date (Print):July 1, 1955Publication History Published online1 May 2002Published inissue 1 July 1955https://doi.org/10.1021/ja01618a063RIGHTS & PERMISSIONSArticle Views131Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (376 KB) Get e-Alertsclose Get e-Alerts
Assessment of Laboratory and Field Assays of Sunlight-Induced Killing of Mosquito Larvae by Photosensitizers (2005)

The effectiveness of light-induced killing of mosquito larvae in the presence of photosensitizers was studied with larvae of Aedes aegypti (L.), Anopheles stephensi (Liston), and Culex quinquefasciatus Say grown in the laboratory and of Cx. quinquefasciatus grown under field conditions. Tested photosensitizers included xanthene, chlorin, and porphyrin derivatives. All the larvae were treated at the fourth instar. Preliminary laboratory experiments showed a light-induced lethal effect of Rose Bengal (RB) on three species of mosquito larvae. Compared with other photosensitizers, RB seemed to be more efficient at even lower concentration than chlorin (e6) and chlorophyllin on Ae. aegypti larvae. Among the four porphyrin derivatives, i.e., chloroquinoline tetraphenyl propioamidoporphine, tetraphenyl porphine tetrasulfonate, hematoporphyrin (HP), and tetraphenylporphine-propionic acid porphine, HP was the only effective photosensitizer on Ae. aegypti larvae. The best conditions for field tests using RB were conducted on Cx. quinquefasciatus in Bobo-Dioulasso, Burkina Faso. The mortality induced by RB varied from 80 to 96% obtained with unfiltered cesspit water to 0.4 to 6.7% in cesspits with a heavy load of organic materials, thus providing the basis for further developments of this technique under field conditions.
Vertebrate Safety of Clostridium bifermentans Serovar malaysia, a New Larvicidal Agent for Vector Control (1992)

The safety of bacterial cells of Clostridium bifermentans serovar malaysia, which is highly toxic to mosquito larvae, was tested on mice, guinea pigs, rabbits, and goldfish. Inoculations of at least 1 x 10(8) cells per animal by routes recommended by World Health Organization (subcutaneous, percutaneous, inhalation, force-feeding, intraperitoneal, intravenous) and tests of subacute toxicity, anaphylactic shock, persistence in heart blood, and virulence by successive passages, were performed on mice, guinea pigs, or both. Growth was monitored for 1 mo before necropsy. Ocular irritation and skin scarification were tested with rabbits. C. bifermentans serovar malaysia did not induce any mortality or abnormal reactions in mammals at a dose 1,000 times higher than the level established by W.H.O. for the demonstration of safety. Bacterial cells are not toxic to goldfish at a dose 1,000 times higher than the LD50 for the target-mosquito larvae. We conclude that C. bifermentans serovar malaysia bacterial cells are safe for laboratory mammals and goldfish.
Analogs of diadenosine tetraphosphate (Ap4A). (2003)

This review summarizes our knowledge of analogs and derivatives of diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A), the most extensively studied member of the dinucleoside 5',5"'-P1,Pn-polyphosphate (NpnN) family. After a short discussion of enzymes that may be responsible for the accumulation and degradation of Np4)N's in the cell, this review focuses on chemically and/or enzymatically produced analogs and their practical applications. Particular attention is paid to compounds that have aided the study of enzymes involved in the metabolism of Ap4A (Np4N'). Certain Ap4A analogs were alternative substrates of Ap4A-degrading enzymes and/or acted as enzyme inhibitors, some other helped to establish enzyme mechanisms, increased the sensitivity of certain enzyme assays or produced stable enzyme:ligand complexes for structural analysis.
A double-blind randomized placebo-controlled trial with short-term beta-glucuronidase therapy in children with chronic rhinoconjunctivitis and/or asthma due to dust mite allergy. (2006)

BG immunotherapy is efficacious, safe, and well tolerated in allergic children. Moreover, good compliance with the administration of 2 doses per year and the lack of significant side effects makes the benefit/risk ratio of this treatment particularly favorable.
Depression and eating disorders (1998)

Both depressive disorders and eating disorders are multidimensional and heterogeneous disorders. This paper examines the nature of their relationship by reviewing clinical descriptive, family-genetic, treatment, and biological studies that relate to the issue. The studies confirm the prominence of depressive symptoms and depressive disorders in eating disorders. Other psychiatric syndromes which occur with less frequency, such as anxiety disorders and obsessive-compulsive disorders in anorexia nervosa, or personality disorders, anxiety disorders, and substance abuse in bulimia nervosa, also play an important role in the development and maintenance of eating disorders. Since few studies have controlled for starvation-induced physical, endocrine, or psychological changes which mimic the symptoms considered diagnostic for depression, further research will be needed. The evidence for a shared etiology is not compelling for anorexia nervosa and is at most suggestive for bulimia nervosa. Since in contemporary cases dieting-induced weight loss is the principal trigger, women with self-critical or depressive features will be disproportionately recruited into eating disorders. The model that fits the data best would accommodate a relationship between eating disorders and the full spectrum of depressive disorders from no depression to severe depression, with somewhat higher rates of depression in bulimic anorectic and bulimia nervosa patients than in restricting anorexia nervosa patients, but the model would admit a specific pathophysiology and psychopathology in each eating disorder.
Novel Therapeutic Strategies For Angiogenesis Inhibition In Recurrent Ovarian Cancer (2015)

Angiogenesis plays a vital role in ovarian carcinogenesis and has become an important therapeutic target of ovarian cancer. Insights into the genomic complexity of ovarian cancer and modest single-agent activity of targeted agents have led to testing of biologic agent combinations in order to leverage modulation of potentially interactive targets. Many studies have added angiogenesis inhibitors to chemotherapy in ovarian cancer, with progression-free survival improvements only. Novel angiogenesis inhibitor combinations that reflect the science of ovarian cancer are needed. An exciting new direction is the interaction between angiogenesis and DNA damage repair pathways, as both pathways are active therapeutic targets in ovarian cancer. Preclinical studies demonstrate an interaction between hypoxia and inhibition of DNA damage repair. γH2AX, a marker of DNA damage response activation, is necessary for endothelial cell proliferation under hypoxia and in hypoxia-driven neovascularization in vivo. The successful combination of a vascular endothelial growth factor receptor inhibitor and a poly (ADP-ribose) polymerase inhibitor in recent clinical trials has suggested this direction can be an important advance. Further clinical combination strategies of angiogenesis inhibition and other pathways including DNA damage repair pathways are currently in development for treatment of recurrent ovarian cancer.
SEISMIC COEFFICIENTS FOR STEEP SLOPES (1970)

As part of an effort to develop a simplified procedure to determine the seismic stability of steep natural slopes, average seismic coefficients for a range of steep slope angles are developed. A new numerical technique based on the Generalized Hyperelement (Deng) is used to determine the seismic response of three steep slopes, composed of weakly cemented sand, known to have experienced seismically induced slope failures. The results show that, in general, the average seismic coefficient increases with slope angle, and is dependent on the frequency content of the earthquake. The results also show that the normalized average seismic coefficient profile for these slopes exceeds the upper and lower bounds presented by Makdisi and Seed, but that Makdisi and Seed's results present a reasonable average, except for the steepest of slopes.
Stereoselective Construction of cis‐2,6‐Disubstituted Tetrahydropyrans via the Reductive Etherification of δ‐Trialkylsilyloxy Substituted Ketones: Total Synthesis of (‐)‐Centrolobine. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Macromolecular Crowding Accelerates Amyloid Formation by Human Apolipoprotein C-II (2002)

Human apolipoprotein C-II (apoC-II) slowly forms amyloid fibers in lipid-free solutions at physiological pH and salt concentrations (Hatters, D. M., MacPhee, C. E., Lawrence, L. J., Sawyer, W. H., and Howlett, G. J. (2000) Biochemistry 39, 8276--8283). Measurements of the time dependence of solution turbidity, thioflavin T reactivity, and the amount of sedimentable aggregate reveal that the rate and extent of amyloid formation are significantly increased by the addition of an inert polymer, dextran T10, at concentrations exceeding 20 g/liter. High dextran concentrations do not alter the secondary structure of the protein, fiber morphology, or the thioflavin T and Congo Red binding capacity of apoC-II amyloid. Analytical ultracentrifugation studies show that monomeric apoC-II does not associate significantly with dextran. The observed dependence of the overall rate of amyloid formation on dextran concentration may be accounted for quantitatively by a simple model for nonspecific volume exclusion. The model predicts that an increase in the fractional volume occupancy of macromolecules in a physiological fluid can nonspecifically accelerate the formation of amyloid fibers by any amyloidogenic protein.