gebhart/patrepeval huggingface dataset:
Aging Modulates the Influence of Arginase on Endothelial Dysfunction in Obesity (2018)

Objective- Arginase can reduce NO availability. In this study, we explored arginase as a determinant of endothelial dysfunction in small arteries from obese patients and its relationship with aging and microvascular remodeling. Approach and Results- Small arteries were dissected after subcutaneous fat biopsies and evaluated on a pressurized micromyograph. Endothelium-dependent vasodilation was assessed by acetylcholine, repeated under L-NAME ( N <sup>G</sup>-nitro-L-arginine-methyl ester), N(ω)-hydroxy-nor-l-arginine (arginase inhibitor) and gp91ds-tat (NADPH [nicotinamide adenine dinucleotide phosphate oxidase] oxidase inhibitor) in vessels from young (age <30 years) control and obese and old (>30 years) control and obese subjects. Media-lumen ratio and amount of vascular wall fibrosis were used as markers of vascular remodeling. Amount of vascular superoxide anions and NO production were determined with immunofluorescence, whereas arginase expression was quantified using Western blot and quantitative polymerase chain reaction. Obese and older age groups had lower vascular NO, as well as higher media-lumen ratio, wall fibrosis, intravascular superoxide, and blunted inhibitory effect of L-NAME on acetylcholine versus controls and younger age groups. N(ω)-hydroxy-nor-l-arginine restored the acetylcholine-induced vasodilation in young and, to a lesser extent, in old obese subjects. This effect was abolished by addition of L-NAME. Gp91ds-tat increased the vasodilatory response to N(ω)-hydroxy-nor-l-arginine in old obese. Superoxide anions and arginase I/II levels were higher in the vascular wall of obese versus controls. Conclusions- Arginase contributes to microvascular endothelial dysfunction in obesity. Its impact is reduced by aging because of higher levels of vascular oxidative stress. Obesity is accompanied by accelerated microvascular remodeling, the extent of which is related to the amount of arginase in the vascular wall.
<title>Intrapixel response test system for multispectral characterization</title> (1999)

We report on the design of a system used to measure the multispectral intrapixel response of imaging sensor arrays. An Airy disk spot size of approximately 4 micrometers has been achieved for wavelength bands that extend from the visible blue to near IR. The automated system does rapid intrapixel row and/or column spatial mapping of individual pixels as well as rastered 2D spatial scans over multi-pixel girds. Commercially available equipment including a photometric eyepiece, a reflective objects, programmable pushers, and light-emitting diodes are utilized in the system. Scanned results using the system are presented for both front- and back-illuminating charge-coupled device imagers. The intrapixel response of a front-illuminated device shows good correlation with the physical cross section of the devices tested.
Energy-efficient Resource Allocation for UAV-empowered Mobile Edge Computing System (2020)

Unmanned aerial vehicles (UAVs) have been gained significant attention from mobile network operators (MNOs) to provision low-latency wireless big data applications, where a number of ground resource-limited user equipments (UEs) can be served by UAVs equipped with powerful computing resources, in comparison with UEs. In this paper, a novel UAV-empowered mobile edge computing (MEC) network architecture is considered. An energy consumption and task execution delay minimization multi-objective optimization problem is formulated, subject to numerous QoS constraints. A heuristic algorithm is proposed to solve the challenging optimization problem, which consists of the task assignment, differential evolution (DE)-aided and non-dominated sort steps. The selected key performance of the proposed algorithm is given and compared with the existing advanced particle swarm optimization (PSO) and non-dominated sorting genetic algorithm II (NSGA-II). The results show that the proposed heuristic algorithm promises higher energy efficiency than PSO and NSGA-II under the same task execution time cost.
The good Samaritan glutathione-S-transferase P1: An evolving relationship in nitric oxide metabolism mediated by the direct interactions between multiple effector molecules (2022)

Glutathione-S-transferases (GSTs) are phase II detoxification isozymes that conjugate glutathione (GSH) to xenobiotics and also suppress redox stress. It was suggested that GSTs have evolved not to enhance their GSH affinity, but to better interact with and metabolize cytotoxic nitric oxide (NO). The interactions between NO and GSTs involve their ability to bind and store NO as dinitrosyl-dithiol iron complexes (DNICs) within cells. Additionally, the association of GSTP1 with inducible nitric oxide synthase (iNOS) results in its inhibition. The function of NO in vasodilation together with studies associating GSTM1 or GSTT1 null genotypes with preeclampsia, additionally suggests an intriguing connection between NO and GSTs. Furthermore, suppression of c-Jun N-terminal kinase (JNK) activity occurs upon increased levels of GSTP1 or NO that decreases transcription of JNK target genes such as c-Jun and c-Fos, which inhibit apoptosis. This latter effect is mediated by the direct association of GSTs with MAPK proteins. GSTP1 can also inhibit nuclear factor kappa B (NF-κB) signaling through its interactions with IKKβ and Iκα, resulting in decreased iNOS expression and the stimulation of apoptosis. It can be suggested that the inhibitory activity of GSTP1 within the JNK and NF-κB pathways may be involved in crosstalk between survival and apoptosis pathways and modulating NO-mediated ROS generation. These studies highlight an innovative role of GSTs in NO metabolism through their interaction with multiple effector proteins, with GSTP1 functioning as a "good Samaritan" within each pathway to promote favorable cellular conditions and NO levels.
Dissociation Characteristics of Endothelin Receptor Agonists and Antagonists in Cloned Human Type-B Endothelin Receptor (1997)

The human type-B endothelin receptor (h-ETB) was cloned from human lung poly A+RNA and stably expressed in CHO cells. Endothelin (ET) receptor binding and stimulation of PI hydrolysis demonstrated that the cloned h-ETB receptor is functional and linked to intracellular signal transduction pathways in CHO cells. The molecular mass of the h-ETB receptor was determined to be 65 KDa, and Bmax and Kd were 0.36 pmol/mg and 80 pM, respectively. Competition studies employing receptor ligands revealed that the potencies of the test ligands (IRL1620, PD142893, and Ro46-2005) were dependent on the length of the incubation time, whereas the natural agonists (ET-1 and ET-3) were not. When competing with ET-1 in the h-ETB receptor binding, the IC50 increased from 1.2 nM to 8.2 nM for IRL1620, 0.068 microM to 1.9 microM for PD142893, and 0.76 microM to 12.7 microM for Ro46-2005, as the incubation time increased from 1 hr to 24 hr. These time-induced changes are likely due to differences in the dissociation characteristics between the artificial ligands and the natural ligands.
Influence of Chemical Cleaning on Physicochemical Characteristics and Ion Rejection by Thin Film Composite Nanofiltration Membranes (2019)

The impact of membrane cleaning with NaOH and HCl on the characteristics and associated changes in ion rejection was investigated in this study. NaOH affected the zeta potential of membranes with a greater concentration of carboxylic groups so that it was negative across the entire pH range investigated. Exposure to NaOH led to swelling of the active layer after each cleaning, especially for poly(piperazineamide) membranes. A 23% increase in the effective pore radii for these membranes after NaOH cleaning for 18 h led to 25, 36, 53 and 62% decrease in the rejection of magnesium, calcium, sodium, and chloride ions, respectively. Sulfate rejection decreased only slightly even for poly(piperazineamide) membranes (i.e., 7%) despite an appreciable increase in pore radii, which can be explained by the impact of charge exclusion on ion rejection that was enhanced by the 16% reduction in zeta potential. On the other hand, cleaning with HCl had a negligible impact on the zeta potential and performance of all membranes evaluated in this study. The increase in permeability after chemical cleaning was in agreement with the decrease in rejection of inorganic ions and correlated well with the effective pore radii measured using the membrane potential technique. The importance of charge exclusion in the rejection of inorganic ions was highlighted by the observed differences in rejection and permeability values when testing membranes after NaOH cleaning.
Supracondylar Humerus Fractures (2021)

This chapter presents a case scenario of a five-year-old girl who sustains a left supracondylar humerus fracture after a fall from the monkey bars. The gold standard in the treatment of displaced pediatric supracondylar humerus fractures is closed reduction with percutaneous pinning. The anterior approach is the best used in cases of possible vascular injury since it allows for exploration of the brachial artery. The gold standard for operative treatment of supracondylar humerus fractures is closed reduction with percutaneous fixation. There is a higher likelihood of open reduction in the flexion type supracondylar humerus fracture. Since the median nerve runs is in anatomic proximity to the brachial artery, a median nerve deficit should prompt more suspicion for vascular injury and the need for open exploration in a pulseless supracondylar humerus fracture. The chapter also provides recommendations for implementing evidence-based practice in the clinical setting.
Radium-223 Chloride: Extending Life in Prostate Cancer Patients by Treating Bone Metastases (2013)

The treatment scope for patients with metastatic castrate-resistant prostate cancer (mCRPC) is rapidly expanding. On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium-223 chloride ((223)RaCl2) for the treatment of mCRPC patients whose metastases are limited to the bones. Radium-223 is an α-emitting alkaline earth metal ion, which, similar to calcium ions, accumulates in the bone. In a phase III study (ALSYMPCA), mCRPC patients with bone metastases received best standard-of-care treatment with placebo or (223)RaCl2. At a prespecified interim analysis, the primary endpoint of median overall survival was significantly extended by 3.6 months in patients treated with radium-223 compared with placebo (P < 0.001). The radioisotope was well tolerated and gave limited bone marrow suppression. (223)RaCl2 is the first bone-targeting antitumor therapy that received FDA approval based on a significant extended median overall survival. Further studies are required to optimize its dosing and to confirm its efficacy and safety in cancer patients.
Digital beam-forming super wideband multi-beam hybrid antenna system (2014)

The design of super wideband digital antenna array is considered. The hybrid reflector antenna contains a mirror forming narrow beam and array of log-periodical elements. Some variants of antenna structure, technical parameters of log-periodical antenna arrays and several types of mirrors are discussed. Results of beam forming with help of linear and non-linear algorithms are presented.
Fiber-reinforced ceramic composites made by chemical vapor infiltration (1985)

A process was developed for the fabrication of ceramic-fiber-reinforced ceramic-matrix composites by chemical vapor infiltration. The ceramic composites were prepared by making fibrous preforms from multiple layers of SiC cloth and forming the silicon-carbide matrix for each component specimen by infiltrating the fibrous preform by a chemical vapor deposition process. A major goal of the work was achieved when infiltration was accomplished in hours instead of weeks by combining the thermal-gradient and forced-gas-flow techniques. Composites that possessed moderate flexural strength and high strain to failure were produced. In addition, the strength of the composites decreased gradually after the maximum strength was obtained, demonstrating that the composites had the desired high toughness and avoided the typical brittle behavior of monolithic ceramics.
ExtraNet (2021)

Both the frame rate and the latency are crucial to the performance of realtime rendering applications such as video games. Spatial supersampling methods, such as the Deep Learning SuperSampling (DLSS), have been proven successful at decreasing the rendering time of each frame by rendering at a lower resolution. But temporal supersampling methods that directly aim at producing more frames on the fly are still not practically available. This is mainly due to both its own computational cost and the latency introduced by interpolating frames from the future. In this paper, we present ExtraNet, an efficient neural network that predicts accurate shading results on an extrapolated frame, to minimize both the performance overhead and the latency. With the help of the rendered auxiliary geometry buffers of the extrapolated frame, and the temporally reliable motion vectors, we train our ExtraNet to perform two tasks simultaneously: irradiance in-painting for regions that cannot find historical correspondences, and accurate ghosting-free shading prediction for regions where temporal information is available. We present a robust hole-marking strategy to automate the classification of these tasks, as well as the data generation from a series of high-quality production-ready scenes. Finally, we use lightweight gated convolutions to enable fast inference. As a result, our ExtraNet is able to produce plausibly extrapolated frames without easily noticeable artifacts, delivering a 1.5× to near 2× increase in frame rates with minimized latency in practice.
Scalable quantum processor noise characterization (2020)

Measurement fidelity matrices (MFMs) (also called error kernels) are a natural way to characterize state preparation and measurement errors in near-term quantum hardware. They can be employed in post processing to mitigate errors and substantially increase the effective accuracy of quantum hardware. However, the feasibility of using MFMs is currently limited as the experimental cost of determining the MFM for a device grows exponentially with the number of qubits. In this work we present a scalable way to construct approximate MFMs for many-qubit devices based on cumulant expansions. Our method can also be used to characterize various types of correlation error.
Quantification of the Effect of Cooling Mists on Individual Thermal Comfort (2010)

Fine water mists are being increasingly used as an efficient means to create “cool spots ” in outdoor and semi-enclosed areas. Evaluation of the effectiveness of this cooling in humid urban areas has largely been limited to direct measurement of air temperature changes and thermal comfort surveys. A prototype analogue of a human arm is developed as an aid to quantifying the effect of mist on thermal comfort by measuring its effect on skin temperature. Using paraffin as a material and a thermal camera to record temperatures, the direct effect of fine mists on skin temperatures can be simulated. Reductions in skin temperature are 2 to 3 times expected air temperature reductions.
Prognostic Significance of E2F3 Expression in Bladder Cancer (2006)

Purpose: E2F3 is important for cell cycle regulation and DNA replication. Recent studies have reported that members of the E2F family can play specific and diverse roles in the tumorigenesis of human malignancies, and the E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in bladder tumors. We studied the prognostic significance of E2F3 expression in bladder cancer. Materials and Methods: We examined the expression of E2F3 with using immunohistochemical staining in the tumor samples from 109 patients suffering with bladder cancer, and we analyzed the prognostic significance of E2F3 according to the grade, stage, recurrence and progression of bladder cancer. Results: We found positive staining for E2F3 in 23 cases (21.1%). The E2F3 expression was correlated with the tumor stage (superficial vs. invasive, p<0.001) and the tumor grade (p=0.001). The E2F3 expression was not correlated with the recurrence and progression of superficial bladder cancer. Conclusions: In this study, our results showed that the E2F3 expression was observed in a portion of the bladder cancer specimens. These results suggest that E2F3 may contribute to the development of bladder cancer, but it may not play a role as a prognostic factor of bladder cancer. (Korean J Urol 2006;47:75-79) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure (2021)

Gap closure is a dynamic process in wound healing, in which a wound contracts and a provisional matrix is laid down, to restore structural integrity to injured tissues. The efficiency of wound closure has been found to depend on the shape of a wound, and this shape dependence has been echoed in various <i>in vitro</i> studies. While wound shape itself appears to contribute to this effect, it remains unclear whether the alignment of the surrounding extracellular matrix (ECM) may also contribute. In this study, we investigate the role both wound curvature and ECM alignment have on gap closure in a 3D culture model of fibrous tissue. Using microfabricated flexible micropillars positioned in rectangular and octagonal arrangements, seeded 3T3 fibroblasts embedded in a collagen matrix formed microtissues with different ECM alignments. Wounding these microtissues with a microsurgical knife resulted in wounds with different shapes and curvatures that closed at different rates. Observing different regions around the wounds, we noted local wound curvature did not impact the rate of production of provisional fibronectin matrix assembled by the fibroblasts. Instead, the rate of provisional matrix assembly was lowest emerging from regions of high fibronectin alignment and highest in the areas of low matrix alignment. Our data suggest that the underlying ECM structure affects the shape of the wound as well as the ability of fibroblasts to build provisional matrix, an important step in the process of tissue closure and restoration of tissue architecture. The study highlights an important interplay between ECM alignment, wound shape, and tissue healing that has not been previously recognized and may inform approaches to engineer tissues. Impact statement Current models of tissue growth have identified a role for curvature in driving provisional matrix assembly. However, most tissue repair occurs in fibrous tissues with different levels of extracellular matrix (ECM) alignment. Here, we show how this underlying ECM alignment may affect the ability of fibroblasts to build new provisional matrix, with implications for <i>in vivo</i> wound healing and providing insight for engineering of new tissues.
ChemInform Abstract: Synthetic DNA Knots and Catenanes (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interleukin-2-based therapy for metastatic renal cell cancer: the Cytokine Working Group experience, 1989-1997. (1997)

Complete response rate and response duration appear to favor the high-dose intravenous rIL-2 regimen. This will require verification in a randomized study comparing the best high-dose arm (rIL-2 alone) with the best outpatient regimen (rIL-2/IFN-alpha). The Cytokine Working Group is currently conducting such a study.
CrossMDA2: Uma Abordagem Baseada em Modelos para Gerência de Evolução de Pointcuts (2009)

Este artigo propõe uma abordagem baseada em modelos para gerência da evolução de pointcuts em aplicações orientada a aspectos. A abordagem é centrada na definição de pointcuts com base em visões conceituais. Na abordagem os pointcuts são especificados como parte de visões do modelo conceitual e o processo é apoiado por uma ferramentas baseada em Model-Driven Architecture (MDA). Como prova de conceito, o artigo apresenta duas versões de um estudo de caso, configurando um cenário de evolução que mostra como o uso de pointcuts baseados em visões conceituais auxiliam na detecção e minimização da fragilidade de pointcuts. Para avaliação da proposta é usada o Goal/Question/Metric (GQM) juntamente com métricas para análise da eficiência na definição dos pointcuts.
Supplementary Figure 8 from Pomalidomide Inhibits PD-L1 Induction to Promote Antitumor Immunity (2023)

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A Conformationally Constrained Vasopressin Analog with Antidiuretic Antagonistic Activity (1984)

Application of information derived from a three-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a bicyclic vasopressin analog, [5,8-cyclo(1-beta-mercaptopropionic acid,2-phenylalanine,5-aspartic acid,8-lysine)]vasopressin. The analog acts as an antagonist of the antidiuretic activity of vasopressin.
Microstructurally small fatigue crack growth in thin, aluminum-alloy, pressure vessel liner (2011)

Motivation to decrease weight and cost of composite-overwrapped pressure vessels used in space exploration leads to designs that challenge the current qualification standards and methods for predicting fatigue life of the structures. Namely, as thickness of the metallic, overwrapped liners is reduced (potentially to tens of grains through-thickness), plastic deformation extends to the liner bounds, and linear elastic fracture parameters become invalid for fatigue crack growth characterization. In this case, fatigue crack growth is likely governed by microstructural features of the material. Life predictions should ultimately reflect this microstructural dependence. In this work, we design a study that involves both experimental and computational modeling aspects to gain three-dimensional perspective of the microstructural features influencing fatigue crack growth in a thin aluminum alloy reminiscent of a metallic liner material. High-energy X-ray diffraction microscopy is explored as a method for characterizing microstructural morphology, including crystallographic orientations, in a volume of material containing a microstructurally small fatigue crack. Initial work involves a feasibility study of the material form (rolled sheet versus actual liner material) to be used in the proposed experimental study. An outlook on future work of the study is provided.