gebhart/patrepeval huggingface dataset:
Pharmacological treatment of systemic sclerosis-associated interstitial lung disease: an updated review and current approach to patient care (2022)

Interstitial lung disease (ILD) has a high prevalence among patients with systemic sclerosis (SSc), carrying high mortality and morbidity. During the last decade, the emergence of new pharmacological therapies for SSc-associated ILD (SSc-ILD) and improved tools for its diagnosis and monitoring have changed the prevailing clinical approach, highlighting the need for early recognition and prompt treatment for SSc-ILD. Furthermore, the recent approval of multiple therapies for SSc-ILD poses challenges for the rheumatologist and pulmonologist in choosing the appropriate therapy for individual clinical scenarios. We review the pathophysiology of SSc-ILD, and the mechanisms of action and rationale behind current therapies. We also review the evidence of the efficacy and safety of immunosuppressive drugs, antifibrotic agents, and immunomodulators from cyclophosphamide and mycophenolate to novel agents such as nintedanib and tocilizumab. We also emphasise the importance of early diagnosis and monitoring and describe our approach to pharmacological therapy for SSc-ILD patients.
An innovations approach to least-squares estimation--Part VII: Some applications of vector autoregressive-moving average models (1973)

We use the innovations method to solve some linear estimation problems for stochastic processes described as the solution of high-order linear difference equations driven by colored noise. Such models are often called vector or multivariable auto-regressive-moving average (ARMA) models. We illustrate how the use of ARMA models can provide some simplifications and some new results in the problem of state estimation in colored noise.
New bioluminescent coelenterazine derivatives with various C-6 substitutions (2017)

A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueC™ or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.
Amplitude Modulated Video Camera - Light Separation in Dynamic Scenes (2016)

Controlled light conditions improve considerably the performance of most computer vision algorithms. Dynamic light conditions create varying spatial changes in color and intensity across the scene. These condition, caused by a moving shadow for example, force developers to create algorithms which are robust to such variations. We suggest a computational camera which produces images that are not influenced by environmental variations in light conditions. The key insight is that many years ago, similar difficulties were already solved in radio communication, As a result each channel is immune to interference from other radio channels. Amplitude Modulated (AM) video camera separates the influence of a modulated light from other unknown light sources in the scene, Causing the AM video camera frame to appear the same - independent of the light conditions in which it was taken. We built a prototype of the AM video camera by using off the shelf hardware and tested it. AM video camera was used to demonstrate color constancy, shadow removal and contrast enhancement in real time. We show theoretically and empirically that: 1. the proposed system can produce images with similar noise levels as a standard camera. 2. The images created by such camera are almost completely immune to temporal, spatial and spectral changes in the background light.
593. N-oxides and related compounds. Part XVII. The tautomerism of mercapto- and acylamino-pyridine 1-oxides (1960)

R. A. Jones and A. R. Katritzky, J. Chem. Soc., 1960, 2937 DOI: 10.1039/JR9600002937
Cleavable Linkers for Porous Silicon‐Based Mass Spectrometry (2004)

Dip, wash, and analyze: Molecules can be attached to tailored porous silicon wafers by using Diels–Alder reactions and efficiently detached and detected in the laser pulse of a MALDI mass spectrometer in a positionally encoded manner (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52803_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
COMPARATIVE STUDIES ABOUT KINEMATICS OF MAXIMAL SPRINT RUNNING AND RUNNING UP IN HORSE VAULTING (2008)

INTRODUCTION: Effective running up is known as an important factor for successful completion of horse vaulting. Some examined the relationship of mechanical parameters of pre-flight and/or post-flight with gymnasts’ performance. However, running up kinematics and its running velocity have been neglected. So the purposes of present study were 1) to compare the kinematics of running up during horse vaulting with that of sprint running, and 2) to investigated the relationships of running velocities and scores of horse vaulting.
Pharmacological Study of Mentha longifolia Phenolic Extracts (1996)

The effect of M. longifolia crude ethanol extract (F1), as well as fractions rich in luteolin glycosides (F2), apigenin glycosides (F3) and phenolic acids (F4) on intestine motility, spontaneous motility, pentobarbital induced sleep and bile secretion have been investigated. The crude ethanol extract was effective only on intestinal motility, apigenin and luteolin glycosides active on spontaneous motility. Phenolic acids were found to possess significant spasmodic, choleretic and CNS stimulative effects.
Universal Approach for Accurate Measurement of Dispersive Characteristics of Optical Microresonators (2021)

Novel approach for measuring the dispersive characteristics of optical microresonators is developed. Considered method is based on application of Mach-Zehnder interferometer and can be used for any wavelength range.
Towards in situ Single Cell Systems Biology (2016)

Systems-level studies of biological systems rely on observations taken at a resolution lower than
the essential unit of biology, the cell. Recent technical advances in DNA sequencing have enabled
measurements of the transcriptomes in single cells excised from their environment, but it remains a
daunting technical problem to reconstruct in situ gene expression patterns from sequencing data. In
this thesis I develop methods for the routine, quantitative in situ measurement of gene expression
using fluorescence microscopy. The number of molecular species that can be measured simultaneously by fluorescence microscopy
is limited by the pallet of spectrally distinct fluorophores. Thus, fluorescence microscopy is traditionally
limited to the simultaneous measurement of only five labeled biomolecules at a time. The
two methods described in this thesis, super-resolution barcoding and temporal barcoding, represent
strategies for overcoming this limitation to monitor expression of many genes in a single cell.
Super-resolution barcoding employs optical super-resolution microscopy (SRM) and combinatorial
labeling via-smFISH (single molecule fluorescence in situ hybridization) to uniquely label individual
mRNA species with distinct barcodes resolvable at nanometer resolution. This method dramatically
increases the optical space in a cell, allowing a large numbers of barcodes to be visualized
simultaneously. As a proof of principle this technology was used to study the S. cerevisiae calcium
stress response. The second method, sequential barcoding, reads out a temporal barcode through
multiple rounds of oligonucleotide hybridization to the same mRNA. The multiplexing capacity of
sequential barcoding increases exponentially with the number of rounds of hybridization, allowing
over a hundred genes to be profiled in only a few rounds of hybridization. The utility of sequential barcoding was further demonstrated by adapting this method to study
gene expression in mammalian tissues. Mammalian tissues suffer both from a large amount of
auto-fluorescence and light scattering, making detection of smFISH probes on mRNA difficult. An
amplified single molecule detection technology, smHCR (single molecule hairpin chain reaction),
was developed to allow for the quantification of mRNA in tissue. This technology is demonstrated
in combination with light sheet microscopy and background reducing tissue clearing technology,
enabling whole-organ sequential barcoding to monitor in situ gene expression directly in intact
mammalian tissue. The methods presented in this thesis, specifically sequential barcoding and smHCR, enable multiplexed
transcriptional observations in any tissue of interest. These technologies will serve as a
general platform for future transcriptomic studies of complex tissues.
Über die stufenweise Quaternisierung von aliphatischen Polyaminen. Neue Verbindungen mit ganglienblockierender Wirkung (1951)

Abstract Es wird die Quaternisierung von Alkylderivaten des Diäthylentriamins, des Dipropylentriamins, sowie des Triäthylentetramins beschrieben. Sie lässt sich stufenweise vornehmen, wobei offenbar zuerst die endständigen Aminogruppen angegriffen werden. Zum Vergleich haben wir auch Sauerstoff‐ und Schwefelverbindungen hergestellt, in denen die Heteroatome sich an der Stelle des mittleren Stickstoffs im Diäthylentriamin befinden.
CoReHAR: A Hybrid Deep Network for Video Action Recognition (2020)

Automating the processing of videos in applications such as surveillance, sport commentary and activity detection, human-machine interaction, and health/disability care is crucial to their correct functioning. In such video processing tasks, recognition of various human actions is a pivotal component for the correct understanding of videos and making decisions upon it. Accurately recognizing human actions is a complex process, demanding high computing capabilities and intelligent algorithms. Several factors, such as object occlusion, camera movement, and background clutter, further challenge the task and its accuracy, essentially leaving deep learning approaches the only viable option for properly detecting human actions in videos. In this study, we propose CoReHAR, a novel Human Action Recognition method that employs both deep Convolutional and Recurrent neural networks on raw video frames. Using the pre-trained ResNet152 CNN, deep features are initially extracted from video frames. The sequential information of the frames is then learned using DB-LSTM RNN. Multiple stacked layers in forward and backward passes of the DB-LSTM provide increased network depth for higher accuracy. A number of techniques are also applied to improve CoReHAR’s processing speed on heterogeneous GPU-enabled systems. The proposed method is evaluated using PyTorch, and is compared to the state-of-the-art methods, showing a considerable efficiency increase, with nearly 95% recognition accuracy measured as an average over all splits of the challenging UCF101 dataset.
A BAD link to mitochondrial cell death in the cochlea of mice with noise‐induced hearing loss (2006)

Acoustic overstimulation induces calcium overload and activation of mitochondria-mediated cell death pathways in outer hair cells (OHC) of the cochlea. However, it is not known whether these events are interrelated or independent. We have recently reported that the calcium-dependent phosphatase calcineurin is activated in OHC following noise exposure and now postulate that calcium overload triggers mitochondria-mediated death pathways through activation of Bcl-2-associated death promoter (BAD) by calcineurin. CBA/J mice were exposed to broadband noise (2-20 kHz), causing a permanent threshold shift of about 40 dB at 12 and 20 kHz, corresponding to damage in the middle and basal turns of the cochlea. Loss of OHC in the basal region was evident in surface preparations. BAD immunostaining in control animals had a cytoplasmic distribution in the cells of the organ of Corti. Five hours after acoustic overstimulation, mitochondria and BAD redistributed to the perinuclear region of OHC in the basal and middle turns but not in the apical turn. The nonapoptotic phospho-BAD (Ser 112) was up-regulated in cells undamaged by noise (supporting cells and inner hair cells) but not in OHC. These data establish a connection between calcium overload and mitochondria-mediated death pathways in OHC and also suggest a dual role for BAD. The translocation of BAD to the mitochondria in degenerating cells is indicative of the activation of its proapoptotic capacity, whereas up-regulation of phospho-BAD is consistent with a nonapoptotic role of BAD in less vulnerable cells.
CCDC 702673: Experimental Crystal Structure Determination (2010)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Precursor-based designs of nano-structures and their processing for Co(W) alloy films as a single layered barrier/liner layer in future Cu-interconnect (2015)

We designed Co(W) films with the self-assembled grain-boundary stuffing as a single-layer barrier/liner for future ULSI Cu-interconnects. HR-TEM and EDX observations confirmed the validity of our materials design and good barrier performance in Co(W) films.
Enhanced Interaction of HLA-DM with HLA-DR in Enlarged Vacuoles of Hereditary and Infectious Lysosomal Diseases (1999)

Following biosynthesis, class II MHC molecules are transported through a lysosome-like compartment, where they acquire antigenic peptides for presentation to T cells at the cell surface. This compartment is characterized by the presence of HLA-DM, which catalyzes the peptide loading process. Here we report that the morphology and function of the class II loading compartment is affected in diseases with a phenotypic change in lysosome morphology. Swollen lysosomes are observed in cells from patients with the hereditary immunodeficiency Chediak-Higashi syndrome and in cells infected with Coxiella burnetii, the rickettsial organism that causes Q fever. In both disease states, we observed that HLA-DR and HLA-DM accumulate in enlarged intracellular compartments, which label with the lysosomal marker LAMP-1. The distribution of class I MHC molecules was not affected, localizing disease effects to the endocytic pathway. Thus, cellular mechanisms controlling lysosome biogenesis also affect formation of the class II loading compartment. Analysis of cell surface class II molecules revealed that their steady-state levels were not reduced on diseased cells. However, in both disease states, enhanced interaction between HLA-DR and HLA-DM was detected. In the Chediak-Higashi syndrome cells, this correlated with more efficient removal of the CLIP peptide. These findings suggest a mechanism for perturbation of Ag presentation by class II molecules and consequent immune deficiencies in both diseases.
Rotated spiral RARE for high spatial and temporal resolution volumetric arterial spin labeling acquisition (2020)

This approach can provide measures of blood flow modulations and resting-state networks for free within any research or clinical protocol employing ASL for resting blood flow.
Innovative Technologies for the Diagnosis of Alcohol Abuse and Monitoring Abstinence (2001)

This article summarizes the proceedings of a workshop presented at the 2000 RSA Meeting in Denver, Colorado. The aim of this workshop was to discuss the basic methodologies, diagnostic performance, and clinical utility of three technologies: carbohydrate-deficient transferrin, the “Early Detection of Alcohol Consumption” score, and whole blood associated acetaldehyde. Each method adopts a different strategy to identify heavy alcohol consumption and offers a unique approach to determine alcohol abstinence and relapses. Appropriate application of these technologies can lead to early intervention for alcohol problems before significant tissue damage occurs. To date these methodologies have yet to be formally contrasted and compared. Sensitivity, specificity, predictive value, availability, ease of use, and interpretation of tests results are important aspects to consider when selecting the most appropriate and cost-effective system. Critical evaluation of these methodologies can enable research and clinical laboratories to choose the system that best meets their particular needs in terms of assay feasibility, budget, and goals.
Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study (2014)

Bevacizumab has promising tolerability. Longer follow-up is needed to identify an effect on the primary endpoint of overall survival at 5 years.
Dual targeting of vascular endothelial growth factor and bone morphogenetic protein‐9/10 impairs tumor growth through inhibition of angiogenesis (2017)

Clinical development of anti-angiogenic agents has been a major landmark in cancer therapy for several types of cancers. Signals mediated by both vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP)-9 and 10 have been implicated in tumor angiogenesis. However, previous studies have shown that targeting the individual signals was not sufficiently effective in retarding tumor growth in certain preclinical and clinical conditions. In the present study, we developed a novel decoy chimeric receptor that traps both VEGF and BMP-9/10. Single targeting of either VEGF or BMP-9/10 signals significantly reduced the formation of tumor vessels in a mouse xenograft model of human pancreatic cancer; however, it did not show significant therapeutic effects on tumor growth. In contrast, dual targeting of the angiogenic signals resulted in more significant inhibition of tumor angiogenesis, leading to delay of tumor growth. Our findings suggest that simultaneous blockade of VEGF and BMP-9/10 signals is a promising therapeutic strategy for the cancers that are resistant to anti-VEGF and BMP-9/10 therapies.
The Production of Cellulases (1969)

Many fungi are cellulolytic, but only a few produce cell-free enzymes that will attack solid cellulose. Trichoderma viride grown on cellulose medium produces a stable cellulase complex including C1. This enzyme is capable of extensive degradation of solid celluloses. Conditions for producing high yields of the enzyme in shake flasks and in a laboratory fermenter are described. Filtrates from these cultures readily hydrolyzed nine cellulose substrates of varying resistance. It is suggested that such culture filtrates could be used to hydrolyze waste cellulose. The hydrolyzate could be used to produce single cell protein or some other fermentation product.
Links to the Future: Communication Requirements and Challenges in the Smart Grid (2011)

Making the smart grid a reality will entail communication capabilities that do not exist in current power grids and their legacy control systems. New grid elements such as distributed energy generation and PHEVs will necessitate changes in these existing communication networks. These changes will be dictated by the need for new control operations that will allow efficient management of these new elements and that cannot be supported by the existing communication infra structure. Moreover, the smart grid will let households man age energy usage more efficiently through AMI and HEMSs. The realization of these systems will require pushing communication networks far out from the network core and deep into homes and buildings. We have presented the communication requirements of the smart grid, and we have identified the main technical challenges that need to be tackled. The only viable way to fulfill these requirements is to design a new communication architecture that can support smart grid services and control operations. This future communication architecture will need to take advantage of the recent progress made in communication technologies and protocols. It will require the introduction of communications technologies that were not considered in the past. In addition, this communication architecture will need to be reliable, scalable, and extendable to future smart grid services and applications.
Electrochemical signal modulation in homogeneous solutions using the formation of an inclusion complex between ferrocene and β-cyclodextrin on a DNA scaffold (2011)

Two DNA conjugates modified with ferrocene and β-cyclodextrin were prepared as a pair of probes that work cooperatively for DNA sensing, in which the electrochemical signal of ferrocene on one probe was significantly "quenched" by the formation of an inclusion complex with β-cyclodextrin of the other probe on the DNA templates.
Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy (2015)

Autologous hematopoietic stem cell (HSC) gene therapy for sickle cell disease has the potential to treat this illness without the major immunological complications associated with allogeneic transplantation. However, transduction efficiency by β-globin lentiviral vectors using CD34-enriched cell populations is suboptimal and large vector production batches may be needed for clinical trials. Transducing a cell population more enriched for HSC could greatly reduce vector needs and, potentially, increase transduction efficiency. CD34(+) /CD38(-) cells, comprising ∼1%-3% of all CD34(+) cells, were isolated from healthy cord blood CD34(+) cells by fluorescence-activated cell sorting and transduced with a lentiviral vector expressing an antisickling form of beta-globin (CCL-β(AS3) -FB). Isolated CD34(+) /CD38(-) cells were able to generate progeny over an extended period of long-term culture (LTC) compared to the CD34(+) cells and required up to 40-fold less vector for transduction compared to bulk CD34(+) preparations containing an equivalent number of CD34(+) /CD38(-) cells. Transduction of isolated CD34(+) /CD38(-) cells was comparable to CD34(+) cells measured by quantitative PCR at day 14 with reduced vector needs, and average vector copy/cell remained higher over time for LTC initiated from CD34(+) /38(-) cells. Following in vitro erythroid differentiation, HBBAS3 mRNA expression was similar in cultures derived from CD34(+) /CD38(-) cells or unfractionated CD34(+) cells. In vivo studies showed equivalent engraftment of transduced CD34(+) /CD38(-) cells when transplanted in competition with 100-fold more CD34(+) /CD38(+) cells. This work provides initial evidence for the beneficial effects from isolating human CD34(+) /CD38(-) cells to use significantly less vector and potentially improve transduction for HSC gene therapy.
Assembly of shape-controlled nanocrystals by depletion attraction (2010)

Recently (Baranov et al., Nano Lett., 2010, 10, 743) we demonstrated that depletion attraction between semiconductor nanorods in solution can be employed for both their self-assembly and their separation from spherical nanoparticles. Here we show that depletion attraction can be used to fabricate binary superlattices of nanorods and 3D networks of octapod/tetrapod-shaped nanocrystals.
Equilibrium Beach Profiles (2001)

During the 1970s and 1980s, the shorefront hotels and businesses at Ocean City, Maryland, an important recreational beach on the East Coast of the United States, were jeopardized by a combination of slow, pervasive shoreline erosion and by their imprudent nearness to the shoreline. Additionally, the beaches were too narrow to accommodate the numerous summer tourists.
Origin and evolution of nondispersive and sterile castes in termites (1994)

info:eu-repo/semantics/published