gebhart/patrepeval huggingface dataset:
A Study of the Properties of Compacts from Silicified Microcrystalline Celluloses (2007)

The paper deals with a study of tensile strength and disintegration time of compacts made from silicified microcrystalline celluloses, Prosolv SMCC 90, and Prosolv HD 90, in dependence on compression force, addition of two types of lubricants, and two active ingredients. The lubricants were magnesium stearate and sodium stearyl fumarate in a concentration of 0.5%, the active ingredients being ascorbic acid and acetylsalicylic acid in a concentration of 50%. Prosolv SMCC 90 proved to be better compatible than Prosolv HD 90; the compacts were of higher strength, which was markedly increased with increasing compression force. Prosolv HD 90 was more sensitive to additions of lubricants, and a greater decrease in strength was recorded due to the influence of sodium stearyl fumarate. The effect of lubricants on the strength of compacts in the presence of active ingredients was not identical. The disintegration time of compacts from Prosolv HD 90 without as well as with lubricants was shorter than from Prosolv SMCC 90 and was increasing with increasing compression force. Disintegration time was increased with added lubricants, and it was markedly shortened by addition of active ingredients. Compacts containing ascorbic acid possessed a shorter disintegration time than those containing acetylsalicylic acid, and it was not markedly influenced by the presence of lubricants.
Real-time animation of cartoon character faces (2014)

Leveraging Mixamo Face Plus technology, this live demo extracts facial expressions in real time at 30 fps from the user and applies these facial expressions to cartoon characters inside a 3D engine. The experience doesn't require calibration and works out of the box.
Introduction (2002)

This book seeks to trace the appropriation of a particular "Old Testament pseudepigraphon" – the Book of Jubilees – in early Christian sources from the New Testament (NT) to Hippolytus (and beyond). More specifically, our study focuses on the reception of Jubilees 8–9, an expansion on the so-called Table of Nations in Genesis 10 (1 Chronicles 1). There are three primary motivations for undertaking such a study at this particular time. First, my previous work on the Table of Nations tradition has led me to the conclusion that Jubilees 8–9 had a powerful influence on geographical conceptions found not only in Second-Temple Jewish sources but also in early Christian writings. In order further to articulate and substantiate this thesis, the present study delves more thoroughly than before into some of the important primary source material. For instance, our study gives greater scope to a Hellenistic epigram that opens up the possibility of Jewish cartographic activity in the Second-Temple period (Chapter 1). The study also augments my previous work by reconsidering the relationship of Jubilees 8–9 both to the lost "Book of Noah" and to other writings of the Second-Temple period (Chapter 2). The study greatly expands our earlier discussion on the geography of Luke-Acts (Chapter 3) and penetrates more deeply into early Christian literature outside the NT (Chapters 4-6). Finally, the study ventures a foray into the medieval mappaemundi as possibly our earliest extant cartographic remains of the Jubilees 8–9 tradition (Chapter 7).
Point of Care: Diagnostics in Hemostasisthe Wrong Direction? (2003)

Point-of-care-testing (POCT) is performance of a laboratory assay outside the laboratory by nontrained personnel. The advantages of POCT are: more rapid medical decisions, avoidance of long sample transports, and small samples. The disadvantages of POCT are: no laboratory personnel, insufficient calibration, quality control and maintenance, poor documentation, high costs, difficult comparability POCT/central laboratory. Therefore, disposing of a 24-hour central laboratory, the POCT spectrum should be limited to the vital parameters: K+, Ca++, Na+, glucose, creatinine, blood gases, hemoglobin or hematocrit, NH3, lactate. POCT offers no advantages, if the hospital has a rapid transport system such as a pneumatic delivery to the central laboratory. The rapid diagnosis of the acute hemostasis state of a patient should be performed in the 24-hour central laboratory that is connected to all hospital wards via a good pneumatic delivery.
Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis (2023)

Serum ferritin levels serves as biomarkers in many inflammatory and infectious diseases. This current systematic review and meta-analysis evaluated whether serum ferritin levels are associated with severe dengue and its utility as a biomarker of disease severity. Literature searches were conducted in PubMed, Scopus, ScienceDirect, the Cochrane library, and Google Scholar. A total of 18 studies examining the serum ferritin levels in dengue cases in the context of disease severity (nine studies having dengue classification as non-severe vs. severe dengue cases, and nine studies having dengue classification as dengue without warning signs (DwoWS), dengue with warning signs (DwWS), and severe dengue cases) were included and the quality of the studies was assessed using the Quality in Prognostic Factor Studies tool. The meta-analysis was performed using STATA software to calculate the effect size as a standardized mean difference (SMD) or Hedges 'g' for the continuous outcome. Higher serum ferritin levels were found in severe dengue cases compared to non-severe cases [SMD (Hedges 'g') 4.05 (95% C.I. 2.09-6.00), (I<sup>2</sup> = 98.8%)]. In the second group, DwWS cases showed high serum ferritin levels compared to DwoWS [SMD 2.01 (95% C.I. 0.92-3.10), (I<sup>2</sup> = 97.89%)], and severe dengue cases showed higher levels of serum ferritin compared to DwWS [SMD 2.66 (95% C.I. 1.72-4.48), (I<sup>2</sup> = 98.78%)] and DwoWS cases [SMD 6.65 (95% C.I. 1.72-11.59), (I<sup>2</sup> = 99.78%]. Subgroup analysis for the country of study (India vs. others), ferritin testing methods, and ferritin measurement day revealed testing method as a significant contributor to heterogeneity. To conclude, the present study suggests serum ferritin as a prognostic marker for dengue disease severity. Multi-centric studies involving a large number of dengue patients with a uniform case definition accounting for all the confounding variables might help in determining a universal cut-off value to discriminate between non-severe and severe dengue.
Diagnosis of a Germ Cell Tumor by Capsule Endoscopy (2008)

Purpose: A 32 year old male with no significant past medical history presented with a 3 day history of dyspnea, left-sided pleuritic chest pain and 2 weeks of melena. He denied abdominal pain, nausea, vomiting, cough, fevers and hemoptysis. He was on no medications and did not have a family history of GI malignancies. Physical exam revealed prominent sinus tachycardia with a rate in the 120s and significant conjunctival pallor. Initial laboratory studies revealed a hemoglobin of 4.9, mcv 72, hematocrit of 14%, and platelets of 550,000. Initial CXR revealed multiple nodules throughout both lung fields. After volume resuscitation an EGD was performed but was non diagnostic. Capsule endoscopy identified the bleeding source in the proximal jejunum within an area of ulceration and stenosis. Push enteroscopy exposed two large, 2–4 cm ulcerated mass lesions 40 cm distal to the pylorus. Multiple biopsies were obtained and pathological analysis was consistent with metastatic choriocarcinoma. CT scans of the head, chest, abdomen, and pelvis revealed multiple metastatic lesions within the brain, lungs, liver, spleen and bilateral kidneys. The patient was started on aggressive chemotherapy and in the immediate follow up period the patient has done well and has had no recurrence of GI bleeding. Capsule endoscopy has rapidly emerged as an effective, non-invasive modality for detecting obscure GI bleeding. A recent study revealed that capsule endoscopy was able to detect small bowel pathology in 82% of patients with GI bleeding of unknown etiology with prior negative results for colonoscopy, EGD, small bowel series, and even angiography. Specifically, it was able to accurately identify small bowel angiodysplasias, polyps, carcinoid tumors, Crohn's disease and metastatic melanomas. Its potential use for early recognition of small bowel tumors is of the utmost importance. As seen in this case, caspsule endoscopy was able to detect a case of previously undiagnosed metastatic germ cell tumor. Only 5% of germ cell tumors (usually embryonal and choriocarcinoma) involve the GI tract. Jejunal involvement is exceedingly rare as around 95% of cases are found within the duodenum. The majority of cases are metastatic upon initial diagnosis and thus confer a relatively poor prognosis. The major complications include intestinal obstruction, bleeding and perforation.
The positive inotropic action of the nifedipine analogue, Bay K 8644, in guinea‐pig and rat isolated cardiac preparations (1985)

The inotropic effect of Bay K 8644 has been studied in rat and guinea-pig atria and ventricular strips stimulated at 1 Hz, in a medium containing CaCl2 1.8 mM. The positive inotropic effect at maximal effective concentrations of Bay K 8644 was in the following order: guinea-pig ventricle greater than rat ventricle greater than guinea-pig atria greater than greater than rat atria. In rat preparations, the tension recorded at maximum effective concentrations of Bay K 8644 was similar at three different calcium concentrations (0.7, 1.8, 3.0 mM). The amplitude of the positive inotropic effect evoked by Bay K 8644 increased when atrial and ventricular contractions were reduced by lowering the external calcium concentration. The contractile tension reached in the presence of maximum effective concentrations of Bay K 8644 (3 X 10(-7) -1 X 10(-6) M) was greater than that produced by the maximum effective concentration of external calcium (3 mM) in rat ventricles but not in rat atria. High doses of nifedipine (3 X 10(-7) -1 X 10(-6) M) depressed the contraction of rat atria more than the contraction of rat ventricles. In rat ventricles, nifedipine shifted to the right the inotropic dose-effect curve of Bay K 8644. It is concluded that the interaction between nifedipine and Bay K 8644 occurred at the same binding sites. These sites have some characteristics of the low affinity binding sites of nifedipine and other related dihydropyridines.
The role of mannose-binding lectin in health and disease (2003)

Mannose-binding lectin (MBL) is a pattern recognition molecule of the innate immune system. It belongs to the collectin family of proteins in which lectin (carbohydrate-recognition) domains are found in association with collagenous structures. In man, these proteins include serum MBL, lung surfactant protein A (SP-A) and lung surfactant protein D (SP-D). MBL binds to a range of sugars including N-acetyl-D-glucosamine, mannose, N-acetyl-mannosamine, fucose and glucose. This permits the protein to interact with a wide selection of viruses, bacteria, yeasts, fungi and protozoa decorated with such sugars. Unlike the other collectins, MBL bound to microbial surfaces is able to activate the complement system in an antibody and C1-independent manner. This activation is mediated by complexes of MBL with a serine protease called MBL-associated serine protease 2 (MASP-2), which specifically cleaves C4 and C2 to create a C3 convertase enzyme. MBL may also interact directly with cell surface receptors and thereby promote opsonophagocytosis by a complement-independent pathway. It has been suggested that MBL plays an important role in the first hours/days of any primary immune response to a sugar decorated pathogen. This provides the host with a first-line of defence before the adaptive immune system becomes operative and in humans may be particularly important between 6 and 18 months of age when the adaptive system is still immature. MBL deficiency is one of the most common human immunodeficiencies and arises primarily from three single point mutations in exon 1 of the MBL-2 gene. These mutations result in a failure to assemble fully functional multimeric protein. Several studies have shown that deficiency of MBL increases the overall susceptibility of an individual to infectious disease. The most striking example of this is the association of acute respiratory tract infections with MBL deficiency in early childhood. In contrast, there is evidence that for some intracellular parasites MBL deficiency may be protective and this might explain the high frequency of MBL mutations in sub-Saharan Africa and South America. Increasingly, there is evidence that the association between MBL levels and disease is complex. For example, the protein appears to influence the severity of several diseases. The mechanism whereby MBL exerts such effects is unclear but one possibility is through a dose-dependent modulation of pro-inflammatory cytokines.
Clinical Evaluation of Castable Ceramic Veneers (1992)

Laboratory fabricated veneering of discolored or malformed anterior teeth is becoming a widely used technique. Etched Dicor and Dicor Plus ceramic veneers cemented with Dicor Light Activated Cement with Fluoride is one technique available to the practitioner. The purpose of this study was to evaluate the clinical effectiveness of castable ceramic veneers and the cementation system. Forty-three Dicor and 18 Dicor Plus veneers were placed in 12 patients. An intraenamel preparation was completed with a bullet-nosed diamond bur in an ultra-speed handpiece with air-water spray, and a polyvinylsiloxane impression was made. All veneers were fabricated on dies by the same laboratory technician and placed by one practitioner. The restorations were examined by two evaluators at baseline, 3 months, and 1 year, using modified Ryge criteria.
Double Diffusion in a Porous Cavity Saturated with Non-Newtonian Fluid (1998)

A numerical and theoretical study of double-diffusive natural convection within a rectangular porous cavity saturated by a non-Newtonian e uid and characterized by a power-law model is conducted. The conditions on the vertical walls are of a constant temperature and concentration. The theoretical method utilizes the pure scaling arguments to estimate, in an order-of-magnitude sense, the type of e ow and the heat and mass transfer patterns that can develop in the enclosure. The results obtained using the scaling arguments are then verie ed by performing a series of numerical experiments. Numerical solutions for the e owe eld, the temprature and concentration distributions, and the heat and mass transfer rates are obtained for a wide range of parameters. Results are presented for 50 # Ra # 500, 0 # N # 20, 0.1 # Le # 500, and 0.5 # n # 1.6. The order-of-magnitude predictions for the overall heat and mass transfer rates and their respective domains of validity are shown to be in agreement with the results produced by discrete numerical experiments.
Structural properties of strained epitaxial La1+δCrO3 thin films (2019)

Epitaxially strained La1+δCrO3 (LCO) thin films, with δ ranging between −0.25 (Cr-rich) and 0.25 (La-rich), were grown on SrTiO3(001) substrates by solid-source molecular beam epitaxy. The effect of the cationic-stoichiometry deviation (δ) on the structural properties (surface structure, morphology, terminations, and unit-cell parameters) is reported. Whereas deviation from stoichiometry does not significantly affect the structural quality (all films keep a perovskite structure, are epitaxial, atomically flat, fully strained, and present mosaicity below 0.1°); increasing |δ| leads to an increase of the out-of-plane lattice parameter and of the unit-cell volume. These results are of importance for further studies on structure–property relationships in the view to build enhanced LCO-based devices.
QoS supported efficient clustered query processing in large collaboration of heterogeneous sensor networks (2009)

Significant worldwide growth is witnessed in development and deployment of huge numbers of heterogeneous sensor networks. These all brings the issue of state-of-the-art federations or collaborations among such networks. Query Processing operation in such collaborative systems has major challenges: fast and scalable query processing, QoS support for query, flexible and robust collaborative system design etc. To our knowledge there has not been much work done on designing scalable and efficient query processing among the huge collaboration of sensor networks. The work EE-QPS designed a pipelined query optimization problem based on energy efficiency. But with varying demands (energy, delay, reliability etc.) of different queries, the Quality of Service (QoS) support becomes very important. Also, entirely sequential or entirely parallel query processing have problems with latency and scalability. Then a hybrid query processing scheme can have flexibility to deliver better performance for all kinds of collaborative systems. Considering all these aspects, we have proposed QoS-QPS, a QoS supported clustered Query Processing System. We have designed a flexible model for querying cost of sensor networks. The cost model is inexpensive to compute and general enough to apply. Then we propose clustered query processing technique, that utilizes a constrained graph partitioning algorithm. This whole QoS aware query processing technique delivers balanced and efficient clustering of sensor networks based on implication relationship. Comprehensive simulations study shows that our proposed scheme is better than existing techniques in compromising among different system requirements. The results also validate the efficiency, scalability and applicability of QoS-QPS. Further we have analyzed potential architectural issues and possible solutions.
ChemInform Abstract: Biocatalysis for Industrial Green Chemistry (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SSME seal test program: Test results for smooth, hole-pattern and helically-grooved stators (1987)

All of the listed seals were tested in a liquid Halon test facility at high Reynolds numbers. In addition, a helically-grooved-stator seal was tested in an air seal facility. An analysis of the test results with comparisons to theoretical predictions supports the following conclusions: (1) For small seals, the Hirs' friction-factor model is more restricted than had been thought; (2) For smooth seals, predictions of stiffness and damping improve markedly as the radical clearance is reduced; (3) Friction-factor data for hole-pattern-seal stators frequently deviates from the Hirs model; (4) Predictions of stiffness and damping coefficients for hole-pattern-stator seals is generally reasonable; (5) Tests for the hole-pattern stators at reduced clearances show no clear optimum for hole-pattern seals with respect to either hole-area ratio or hole depth to minimum clearance ratios; (6) Tests of these hole-pattern stators show no significant advantage in net damping over smooth seals; (7) Tests of helically-grooved seal stators in Halon show reasonable agreement between theory and prediction for leakage and direct stiffness but poor agreement for the net damping coefficient.
Synthesis of beauvericin by a multifunctional enzyme. (1988)

Beauvericin synthetase, a multifunctional enzyme catalyzing depsipeptide formation in Beauveria bassiana was purified to near homogeneity. The enzyme consists of a single polypeptide chain with a molecular mass of about 250 kdaltons. The mechanism of beauvericin formation is very similar to that of the cyclohexadepsipeptide enniatin. The constituents of the beauvericin molecule, L-phenylalanine and D-alpha-hydroxyisovaleric acid are activated as thioesters via the corresponding adenylates. N-Methylation takes place at the thioester bound stage of the phenylalanine residues. Omission of the methyl donor S-adenosyl-L-methionine results in the formation of demethylbeauvericin. Studies on substrate specificity revealed that phenylalanine could be replaced by a number of other aromatic or aliphatic amino acids like beta-phenylserine, ortho-, meta-, para-fluorophenylalanine, isoleucine, norleucine and leucine. Valine, the constituent amino acid of enniatin B was not accepted by the enzyme.
Untersuchungen zur in vitro Interaktion von Peroxisomen mit Mikrotubuli und der daran beteiligten Bindungsproteine (2001)

Ein semiquantitativer in vitro Bindungsassay, der auf der Bindung reiner Rattenleberperoxisomen an rekonstituierte Mikrotubuli, die an Mikrotiterplatten gekoppelt waren, basiert, wurde entwickelt, um die Interaktionen von Peroxisomen mit Mikrotubuli zu charakterisieren. Die spezifische Bindung der Peroxisomen an Mikrotubuli konnte mit konfokaler Laserscanningmikroskopie und Negativkontrastelektronenmikroskopie gezeigt werden. Die Bindung war konzentrationsabhängig und sättigbar und wurde von Inkubationsdauer, Temperatur und pH beeinflußt. Die Zugabe von ATP, Kinasen, Phosphataseinhibitor oder Motorproteinen erhöhte die Bindung, während ATP-Depletion oder Mikrotubuli-assoziierte Proteine sie verminderte. Eine KCl-Behandlung der Peroxisomen reduzierte die Bindung, was durch Zugabe von dialysiertem KCl-Eluat oder Rattenlebercytosol verhindert wurde. Der rekonstituierende Effekt von Cytosol wurde durch dessen Vorbehandlung mit Proteasen oder N-ethylmaleimid (NEM) aufgehoben. Weiterhin verringerte die Behandlung der Peroxisomen mit Proteasen oder NEM ihre Bindung, was nicht durch Cytosol kompensiert wurde. Dies läßt die Beteiligung eines peroxisomalen Membranproteins und cytosolischer Faktor(en) an der Bindung von Peroxisomen an Mikrotubuli vermuten. Dafür spricht auch, daß bestimmte durch Gelfiltration erhaltene Proteinfraktionen des dialysierten KCl-Eluates die Bindung steigerten. Diese Fraktionen sowie isolierte Peroxisomen zeigten eine starke Immunreaktivität einer Polypeptidbande von 70 kDa mit einem Antikörper gegen das cytoplasmatische Linkerprotein (CLIP)-115. Cosedimentationsexperimente mit Mikrotubuli zeigten die Assoziation dieses Polypeptides an Mikrotubuli. Weiterhin vermochte die Immundepletion des KCl-Eluates mit einem Antikörper gegen die konservierte Mikrotubulibindungsdomäne der CLIPs den stimulierenden Effekt auf die Bindung aufzuheben. Somit scheint ein CLIP-ähnliches 70 kDa Polypeptid an der Bindung von Peroxisomen an Mikrotubuli beteiligt zu sein.
Determining Normative Values for Cerebrospinal Fluid Profiles in Infants (2021)

We determined age-specific normative components for CSF profile values for infants 0 to 90 days.
1‐(1‐Phenethylpiperidin‐4‐yl)‐1‐phenylethanols as Potent and Highly Selective 5‐HT2A Antagonists (2005)

The discovery of a novel class of highly potent and selective 5-HT2A antagonists is reported herein. Selectivity for the serotonin 5-HT2A receptor was optimized, decreasing the affinity of these antagonists toward the adrenergic alpha1 and dopaminergic D2 receptors, and especially to the 5-HT2C receptor. A series of corresponding 7-substituted indoles is described for the first time as serotonergic ligands. The enantiomer R-(+)-1-(4-fluorophenyl)-1-{1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl} ethanol (R-(+)-74) was identified to have superior affinity for the serotonergic 5-HT2A receptor [IC50=0.37 nM] and selectivity toward the dopaminergic D2- [IC50=2300 nM], adrenergic alpha1- [IC50=1000 nM] and 5-HT2C receptors [IC50=490 nM].