gebhart/patrepeval huggingface dataset:
HPLC Method for Determination of p-coumaric acid from the Medicinal Herb Leptadinia reticulata (2011)

The aim of present study was to develop and validate a simple, precise and rapid HPLC method for the quantification of p-coumaric acid in Leptadinia reticulata extractst. The analysis was performed by reverse-phase chromatography on an phenomenex C18 columns with isocratic elution of Methanol and 0.8%-Formic acid in water (6:4) at a flow rate of 1.0mL/min, a column temperature of 35°C, photodiode array detector detection at 326 nm. The method validated in terms of linearity accuracy precision LOD, LOQ and stability. The herb Leptidinia reticulata contains 0.17% p-coumaric acid. The linear range of method was 0.25-50µg/ml with correlation coefficient of 0.9993, the recovery was 98-99.4% and the relative standard deviation is 0.98 % (n=6). The developed method was found to be a relatively simple, precise and reproducible for the quantification of p-coumaric acid. The method does not employ any derivatization procedure and can be used as a quality control tool for the routine analysis of p-coumaric acid from an herb Leptadinia reticulata.
Stereoselective Synthesis of (−)-α-Kainic Acid and (+)-α-Allokainic Acid via Trimethylstannyl-Mediated Radical Carbocyclization and Oxidative Destannylation (1996)

(−)-α-Kainic acid (1) and its C4 epimer (+)-α-allokainic acid (2) have been prepared from l-serine. The requisite stereochemical array in (−)-α-kainic acid (1) was introduced using a trimethylstannyl radical carbocyclization of a diene, which gave the 2,3-trans/3,4-cis and 2,3-trans/3,4-trans compounds in a 2.8:1 ratio and in high yield. The destannylation of the trisubstituted pyrrolidine nucleus was achieved via an oxidative cleavage of the C−Sn bond with ceric ammonium nitrate. This provided a dimethyl acetal that was further transformed into the intended α-kainic acid. When the same radical carbocyclization was attempted on a triene, the 2,3-trans/3,4-trans and the 2,3-trans/3,4-cis adducts were obtained in a 2.5:1 ratio, respectively. This approach was used to synthesize (+)-α-allokainic acid.
Supplementary Table 2 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer (2023)

&lt;p&gt;GSEA analysis of differentially expressed genes in the control versus Prmt1 KO mOS at the transcript level using GO gene sets.&lt;/p&gt;
Pathogenesis of wound healing disorders in the elderly (2017)

The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age-associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy - including stem cells - have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.
Chondral and Osteochondritis Dissecans Lesions Treated by Autologous Chondrocytes Implantation: A Mid- to Long-Term Nonrandomized Comparison (2020)

In the presented retrospective study, the failure rate of first-generation ACI was higher in OCD lesions than in large full-thickness cartilage lesions, suggesting that OCD lesions may associate with properties that affect the durability of repair tissue. Future prospective studies are needed to tell us how to best repair OCD lesions with biological tissue engineering.
Archaeal C80 isoprenoid tetraacids responsible for naphthenate deposition in crude oil processing (2006)

The structure of a novel class of octaterpene tetracarboxylic acids which is responsible for naphthenate deposition in crude oil processing has been determined by NMR and mass spectroscopy.
Effect of n-Alkane Kinetics in Rats on Potency Estimations and the Meyer-Overton Hypothesis (1994)

Neither lipophilicity nor vapor pressure of larger n-alkanes appear to correlate with their anesthetizing partial pressures in inspired gas. Such results suggest that the Meyer-Overton hypothesis and Ferguson's rule may not apply to these compounds. An alternative explanation might be that a large difference in inspired-to-arterial partial pressure exists, i.e., that the inspired partial pressure misrepresents the effective partial pressure. To test this explanation, we investigated the kinetics of five consecutive even-numbered n-alkanes (C2H6 to C10H22) in rats. The ratio of end-tidal-to-inspired (PA/PI), arterial-to-end-tidal (Pa/PA), and arterial-to-inspired (Pa/PI) partial pressures decreased with increasing carbon chain length, consistent with our separate finding that blood solubility increased. Using Pa/PI and the minimum inspired concentration (MIC) obtained previously, we calculated the true effective potency, minimum alveolar anesthetic concentration (MAC); of these n-alkanes as (Pa/PI)(MIC). This markedly improved, but did not perfectly correct, the correlation of MAC with lipid solubility (the Meyer-Overton hypothesis) and vapor pressure (Ferguson's rule). A coefficient of variation of 76.7% was found for the product of MAC and the olive oil/gas partition coefficient. More importantly, the correlation of the logarithm of MAC and oil solubility had a slope of -0.724 (i.e., deviated from -1.0), whereas the slope for eight conventional anesthetics was -1.046 (approached-1.0). These data imply that olive oil does not adequately mimic the nature of the anesthetic site of action of n-alkanes.
Parallel code clone detection using MapReduce (2012)

Code clone detection is an established topic in software engineering research. Many detection algorithms have been proposed and refined but very few exploit the inherent parallelism present in the problem, making large scale code clone detection difficult. To alleviate this shortcoming, we present a new technique to efficiently perform clone detection using the popular MapReduce paradigm. Preliminary experimental results demonstrates speed-up and scale-up of the proposed approach.
Readout Electronics with Bandpass Delta-Sigma A/D Converter for a Bulk Micromachined Capacitive Gyroscope (2006)

This paper presents a fully integrated readout electronics designed for a bulk micromochined capacitive gynoscope. The readout chain is composed of a charge sensitive amplifer, analog signal processing and a δσ-type A/D converter. The analog signal processing consists of a high-pass filter, a variable-gain amplifier, another high-pass filter and a low-pass filter. The system achieves a measured capacitance sensitivity of 4.00 aF (rms) in a 100 Hz band centered at 8.462kHz, consuming 2.9 mA. The signal frequency can vary between 8-10 kHz, depending on the gyroscope element. A full microelectromechanical angular velocity sensor system has been built using the readout electronics described together with external electronics, and its operation has been verified.
Molecular Insights into Abiotic Stresses in Mango (2023)

Mango (Mangifera indica L.) is one of the most economically important fruit crops across the world, mainly in the tropics and subtropics of Asia, Africa, and Central and South America. Abiotic stresses are the prominent hindrance that can adversely affect the growth, development, and significant yield loss of mango trees. Understanding the molecular physiological mechanisms underlying abiotic stress responses in mango is highly intricate. Therefore, to gain insights into the molecular basis and to alleviate the abiotic stress responses to enhance the yield in the mere future, the use of high-throughput frontier approaches should be tied along with the baseline investigations. Taking these gaps into account, this comprehensive review mainly speculates to provide detailed mechanisms and impacts on physiological and biochemical alterations in mango under abiotic stress responses. In addition, the review emphasizes the promising omics approaches in unraveling the candidate genes and transcription factors (TFs) responsible for abiotic stresses. Furthermore, this review also summarizes the role of different types of biostimulants in improving the abiotic stress responses in mango. These studies can be undertaken to recognize the roadblocks and avenues for enhancing abiotic stress tolerance in mango cultivars. Potential investigations pointed out the implementation of powerful and essential tools to uncover novel insights and approaches to integrate the existing literature and advancements to decipher the abiotic stress mechanisms in mango. Furthermore, this review serves as a notable pioneer for researchers working on mango stress physiology using integrative approaches.
Electrocardiogram (EKG) Guided Peripherally Inserted Central Catheter Placement and Tip Position: Results of a Trial to Replace Radiological Confirmation (2010)

Abstract Background : The current standard of care for Peripherally Inserted Central Catheters (PICCs) is radiological confirmation of terminal tip location. Tip location practices in Europe have used electrocardiographic (EKG) guided positioning for central venous catheters for more than twenty years with tip positioning safely confirmed over thousands of insertions (Madias, 2003). The goal of this group was to confirm the findings of a study performed by Pittiruti and his team; and to establish safe function in the use of EKG guidance for verification of terminal tip position with PICCs placed at McKenzie Willamette Medical Center. Methods : In 2008/2009 McKenzie Willamette Medical Center conducted a study to determine whether or not EKG guidance can be used as a reliable means to accurately place and confirm terminal tip location of PICCs. A group of trained nurses performed PICC placement using EKG guidance followed by radiological confirmation of SVC position. All PICCs placed from October 2008 to December 2009 were included in the study. Tip location was confirmed using either radiological confirmation alone, EKG plus radiological confirmation, or EKG alone. Results : A total of 417 PICCs were placed during the study period. EKG guidance alone was used in the placement and confirmation of 168 PICCs. Both EKG and chest x-ray confirmation were used in the placement of 82 of the PICCs; 240 of the PICCs were placed with the use of EKG and then position correlated using the traditional chest x-ray procedure. Discussion : EKG guided PICC placement proved accurate in consistently guiding the terminal tip to the superior vena cava (SVC). The procedure was easily taught and duplicated by members of the PICC team. The study demonstrated a definite correlation between the height (size) of the P-wave and the location of the terminal tip within the SVC. With knowledge of this correlation, transition from placing PICCs using EKG guidance with chest x-ray confirmation to confirmation of tip placement using just EKG guidance without chest x-ray confirmation was attained. Application of EKG placement/confirmation performed during insertion saves time previously spent waiting for x-ray confirmation readings, saves cost of chest x-ray, prevents patient exposure to radiation and saves time required for tip repositioning of malpositioned tips found after the end of the procedure.
Ionically crosslinked hydrophilic polymer membranes: Synthesis and measurement of transport properties (1973)

Abstract Water soluble polymer and copolymer systems containing a poly(carboxylic acid) as one component have been ionically crosslinked in the form of membranes using multivalent metal salts. The permeability coefficients for a homologous series of poly(ethylene glycols) permeating through the ionically crosslinked membranes and a commercial cellophane membrane were determined using a continuous flow dialysis apparatus. Solute concentration changes occurring during dialysis were determined by using an in‐line continuous flow differential refractometer. For the ionically crosslinked membranes the permeability coefficients were found to decrease exponentially with increasing permeant molecular weight. For the cellophane membrane the permeability coefficients were observed to be inversely proportional to the square root of the permeant molecular weight. This square root correlation appears to be consistent with a porous flow model for transport through cellophane membranes.
Structure-cytotoxic activity relationships of simple hydroxylated coumarins. (2003)

Several hydroxylated and/or methoxylated coumarin derivatives were tested for their relative cytotoxicity on four human tumor cell lines (oral squamous cell carcinoma HSC-2, HSC-3, melanoma A-375 and promyelocytic HL-60) and three normal human cells (gingival fibroblast HGF, periodontal ligament fibroblast HPLF and pulp cell HPC). Tumor cell-specific cytotoxicity was detected in all 6,7-dihydroxy-substituted coumarins only. The observations indicate that the tumor-specific cytotoxicity of the naturally occurring coumarin esculetin can be further enhanced by proper substitutions at 3- and/or 4-position(s) of the molecule. Agarose gel electrophoresis revealed that esculetin and its derivatives with tumor-specific cytotoxicity induce internucleosomal DNA fragmentation in HL-60 cells.
The 100 most cited papers on bone metastasis: A bibliometric analysis (2022)

This study identified the top 100 most cited articles on bone metastasis. Publication time, area, and theme distribution were thoroughly analyzed. The present study highlighted some of the most influential contributions to the field. Clinical and academic communities have shown a sustained interest in the management of bone metastasis.
Regulatory T-Cell Therapy in the Induction of Transplant Tolerance (2014)

Clinical tolerance induction to permit minimization or cessation of immunosuppressive drugs is one of the key research goals in solid organ transplantation. The use of ex vivo expanded or manipulated immunologic cells, including CD4CD25FOXP3 regulatory T cells (Tregs), to achieve this aim is already a reality, with several trials currently recruiting patients. Tregs are a highly suppressive, nonredundant, population of regulatory cells that prevent the development of autoimmune diseases in mammals. Data from transplanted humans and animal models support the notion that Tregs can mediate both induction and adoptive transfer of transplantation tolerance. However, human Tregs are highly heterogeneous and include subpopulations with the potential to produce the proinflammatory cytokine interleukin-17, which has been linked to transplant rejection. Tregs are also small in number in the peripheral circulation, thus they require ex vivo expansion before infusion into man. Selection of the most appropriate Treg population for cell therapy is, therefore, a critical step in ensuring successful clinical outcomes. In this review, we discuss Treg subpopulations, their subdivision based on nonmutually exclusive criteria of origin, expression of immunologic markers and function, availability in the peripheral blood of patients awaiting transplantation, and their suitability for programs of cell-based therapy.
Track quality based multitarget tracking algorithm (2006)

In multitarget tracking alongside the problem of measurement to track association, there are decision problems related to track confirmation and termination. In general, such decisions are taken based on the total number of measurement associations, length of no association sequence, total lifetime of the track in question. For a better utilization of available information, confidence of the tracker on a particular track can be used. This quantity can be computed from the measurement-to-track association likelihoods corresponding to the particular track, target detection probability for the sensor-target geometry and false alarm density. In this work we propose a multitarget tracker based on a track quality measure which uses assignment based data association algorithm. The derivation of the track quality is provided. It can be noted that in this case one needs to consider different detection events than that of the track quality measures available in the literature for probabilistic data association (PDA) based trackers. Based on their quality and length of no association sequence tracks are divided into three sets, which are updated separately. The results show that discriminating tracks on the basis of their track quality can lead to longer track life while decreasing the average false track length.
Learning incoherent light emission steering from metasurfaces using generative models (2023)

Spatiotemporal control over incoherent light sources is critically important for applications such as displays, remote sensing, clean energy, and illumination. Incoherent light emission made up of randomized wavefronts is incompatible with known beam steering techniques that rely on coherent electromagnetic wave interference. The emerging field of tunable dielectric metasurfaces consisting of sub-wavelength arrays of optical nanoresonators has recently enabled active re-direction of incoherent light (photoluminescence, PL) emission. This was achieved by illuminating (pumping) the metasurface with a pump laser reflecting off a programmable spatial light modulator (SLM) with sawtooth grating patterns as input. Achieving efficient beam steering requires the generation of optimal pump patterns programmed into the SLM to maximize the PL emitted towards a given direction. Given the innumerable possibilities and the lack of a theoretical physical framework to guide the exploration of pump patterns, we use an active learning algorithm running a closed loop optical experiment with a generative model to explore and optimize novel pump patterns. We achieve up to an order of magnitude enhancement in the steering efficiency by using pump patterns that are generated by a variational auto-encoder, with minimal number of experiments. The results presented in this paper highlight the unique ability of generative models and active learning to dramatically improve steering efficiency by finding novel optical pump patterns that are beyond human intuition. Our combination of advanced machine learning techniques driving closed loop nanophotonic experiments might pave the way to derive the underlying physics of emergent light-matter phenomena.
ChemInform Abstract: Purines. Part 28. Preparation of Some 3,7‐Dialkyladenines from 3‐Alkyladenines by Alkylation: A Subordinate Formation of 3,9‐Dialkyladenines. (1986)

Abstract Die Alkylierung der 3‐Alkyladenine (I) zu den Dialkyladeninen (II) und (III) wird untersucht.
SPICE Modeling of Piezoelectric Energy Harvesting Device Utilizing Stress Influence (2013)

This paper presents a SPICE modeling of piezoelectric energy harvesting (PEH) device. We developed a wireless sensor system with the PEH device as an application. The PEH device is composed of a stainless cantilever, which has a piezoelectric film on the both side surface. The PEH device oscillates at resonance frequency when the tip of the cantilever is plucked. In SPICE simulator, an equation of motion of the cantilever is described to express a mass-spring-damper system by behavioral source. The stress of the piezoelectric film is computed by theoretical calculation and FEM analysis. Then, the stress, the piezoelectric coefficient d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sub> , and the area of the film surface formulate the electrical charge. The output voltage is given by the charge varying and an inherent capacitance. The comparison between an analysis and an experiment is represented. The output power of theoretical calculation and measurement are 310 μJ and 920 μJ respectively has occurred by plucking once. We also developed a prototype system of WSN node utilizing the PEH device. The system transmits the temperature data a few times by plucking once.
The rheology of suspensions of solid particles (2009)

We present data for the rheology of suspensions of monodisperse particles of varying aspect ratio, from oblate to prolate, and covering particle volume fractions ϕ from dilute to highly concentrated. Rheology is characterized by fitting the experimental data to the model of Herschel &amp; Bulkley (Herschel &amp; Bulkley 1926 Kolloid Z. 39 , 291–300 ( doi:10.1007/BF01432034 )) yielding three rheometric parameters: consistency K (cognate with viscosity); flow index n (a measure of shear-thinning); yield stress τ 0 . The consistency K of suspensions of particles of arbitrary aspect ratio can be accurately predicted by the model of Maron &amp; Pierce (Maron &amp; Pierce 1956 J. Colloid Sci. 11 , 80–95 ( doi:10.1016/0095-8522(56)90023-X )) with the maximum packing fraction ϕ m as the only fitted parameter. We derive empirical relationships for ϕ m and n as a function of average particle aspect ratio r p and for τ 0 as a function of ϕ m and a fitting parameter τ *. These relationships can be used to predict the rheology of suspensions of prolate particles from measured ϕ and r p . By recasting our data in terms of the Einstein coefficient, we relate our rheological observations to the underlying particle motions via Jeffery’s (Jeffery 1922 Proc. R. Soc. Lond. A 102 , 161–179 ( doi:10.1098/rspa.1922.0078 )) theory. We extend Jeffery’s work to calculate, numerically, the Einstein coefficient for a suspension of many, initially randomly oriented particles. This provides a physical, microstructural explanation of our observations, including transient oscillations seen during run start-up and changes of rheological regime as ϕ increases.
Gelation and Water Binding Properties of Transglutaminase‐treated Skim Milk Powder (2000)

ABSTRACT: Transglutaminase (TGase)‐treated skim milk powder (TG‐SMP) was prepared by freeze‐drying skim milk after TGase treatment (10 U/g milk protein, 40°C for 3 h), followed by TGase inactivation at 85°C for 5 min. TGase modification resulted in significant increases in hardness and water holding capacity (WHC) of heat‐induced gels (10% protein, w/v). A marked increase in storage modulus (G′) of TG‐SMP upon heating suggests that TG‐SMP has a greater gelling ability than control‐SMP (C‐SMP) prepared with predenatured TGase. Acid gels prepared from TG‐SMP had a significantly higher WHC at all solid levels (12%, 14%, and 16%) tested and formed a more elastic network than C‐SMP.
External-memory pattern databases using structured duplicate detection (2005)

A pattern database is a lookup table that stores an exact evaluation function for a relaxed search problem, which provides an admissible heuristic for the original search problem. In general, the larger the pattern database, the more accurate the heuristic function. We consider how to build large pattern databases that are stored in external memory, such as disk, and how to use an external-memory pattern database efficiently in heuristic search. To limit the number of slow disk I/O operations needed to construct and query an external-memory pattern data-base, we adapt an approach to external-memory graph search called structured duplicate detection that localizes memory references by leveraging an abstraction of the state space. We present results that show this approach increases the scalability of heuristic search by allowing larger and more accurate pattern database heuristics.
Women and peripheral arterial disease: same disease, different issues (2008)

In PAD, there are several sex differences in baseline characteristics, especially with respect to the weight and significance of cardiovascular risk factors. Knowledge of these differences may help achieve optimal gender-specific cardiovascular risk prevention.