gebhart/patrepeval huggingface dataset:
Validation of an Automated System for Arrival Traffic Management (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-3828.vid The fuel-efficiencies of arrival flights that were managed by an automated system were compared to the fuel-efficiencies of arrival flights that were managed by air traffic controllers. It was infeasible to have the automated system control arrivals in real operations, so the comparison was accomplished by setting up a fast-time simulation where the automated system could manage arrivals with the same initial conditions and flight plans as those that operated in real operations during a selected comparison period and in the same background traffic. For this study, Newark Liberty International Airport was selected as the arrival airport because its high traffic load and constrained arrival procedures were expected to highlight fuel-efficiency benefits of an automated system. In the simulation, the automated system managed Newark arrivals, and the other flights (arrivals to other airports, departures, and overflights) composed the background traffic. To match the simulation and the real operations background traffic, the other flights flew in simulation the same trajectory that they flew in real operations during the comparison period. Fuel-efficiency was measured by calculating fuel burns of the arrival trajectories. The fuel-efficiencies of arrival trajectories produced in the simulation were compared with the estimated fuel-efficiencies of arrival trajectories recorded from real operations during the comparison period. Results showed that automation managed arrivals burned 346 lbs less fuel per flight on average than controller managed arrivals.
The identification of nuclear αvβ3 integrin in ovarian cancer: non-paradigmal localization with cancer promoting actions (2020)

Nuclear translocation of transmembrane proteins was reported in high-grade serous ovarian cancer (HGSOC), a highly aggressive gynecological malignancy. Although the membrane receptor αvβ3 integrin is amply expressed in HGSOC and involved in disease progression, its nuclear localization was never demonstrated. Nuclear αvβ3 was explored in HGSOC cells (OVCAR3, KURAMOCHI, and JHOS4), nuclear localization signal (NLS) modified β3 OVCAR3, Chinese hamster ovaries (CHO-K1) and human embryonic kidney (HEK293) before/after transfections with β3/β1 integrins. We used the ImageStream technology, Western blots (WB), co immunoprecipitations (Co-IP), confocal immunofluorescence (IF) microscopy, flow cytometry for cell counts and cell cycle, wound healing assays and proteomics analyses. Fresh/archived tumor tissues were collected from nine HGSOC patients and normal ovarian and fallopian tube (FT) tissues from eight nononcological patients and assessed for nuclear αvβ3 by WB, confocal IF microscopy and immunohistochemistry (IHC). We identified nuclear αvβ3 in HGSOC cells and tissues, but not in normal ovaries and FTs. The nuclear integrin was Tyr 759 phosphorylated and functionally active. Nuclear αvβ3 enriched OVCAR3 cells demonstrated induced proliferation and oncogenic signaling, intact colony formation ability and inhibited migration. Proteomics analyses revealed a network of nuclear αvβ3-bound proteins, many of which with key cancer-relevant activities. Identification of atypical nuclear localization of the αvβ3 integrin in HGSOC challenges the prevalent conception that the setting in which this receptor exerts its pleiotropic actions is exclusively at the cell membrane. This discovery proposes αvβ3 moonlighting functions and may improve our understanding of the molecular basis of ovarian cancer pathogenesis.
Polar Localizing Class V Myosin Chitin Synthases Are Essential during Early Plant Infection in the Plant Pathogenic Fungus Ustilago maydis (2005)

Fungal chitin synthases (CHSs) form fibers of the cell wall and are crucial for substrate invasion and pathogenicity. Filamentous fungi contain up to 10 CHSs, which might reflect redundant functions or the complex biology of these fungi. Here, we investigate the complete repertoire of eight CHSs in the dimorphic plant pathogen Ustilago maydis. We demonstrate that all CHSs are expressed in yeast cells and hyphae. Green fluorescent protein (GFP) fusions to all CHSs localize to septa, whereas Chs5-GFP, Chs6-GFP, Chs7-yellow fluorescent protein (YFP), and Myosin chitin synthase1 (Mcs1)-YFP were found at growth regions of yeast-like cells and hyphae, indicating that they participate in tip growth. However, only the class IV CHS genes chs7 and chs5 are crucial for shaping yeast cells and hyphae ex planta. Although most CHS mutants were attenuated in plant pathogenicity, Deltachs6, Deltachs7, and Deltamcs1 mutants were drastically reduced in virulence. Deltamcs1 showed no morphological defects in hyphae, but Mcs1 became essential during invasion of the plant epidermis. Deltamcs1 hyphae entered the plant but immediately lost growth polarity and formed large aggregates of spherical cells. Our data show that the polar class IV CHSs are essential for morphogenesis ex planta, whereas the class V myosin-CHS is essential during plant infection.
TOLERABILITY OF SOLIFENACIN IN COMPARISON WITH OXYBUTYNIN IMMEDIATE RELEASE IN PATIENTS WITH OVERACTIVE BLADDER: RESULTS OF THE VECTOR STUDY (2009)

We documented the effects of intradetrusor injections of botulinum neurotoxin type A (Botox®) for refractory idiopathic detrusor overactivity so that prospective patients maybe properly informed about possible improvement in quality of life, the duration of interinjection intervals and the risk of clean intermittent self-catheterization.A total of 81 consecutive patients with refractory idiopathic detrusor overactivity treated with intradetrusor injections of 200 U botulinum neurotoxin type A at 20 sites per injection course were evaluated in this prospective, nonrandomized, open label cohort study. The primary outcome was changes in quality of life, as assessed by the short form of the Urogenital Distress Inventory and the Incontinence Impact Questionnaire before and after treatment. Secondary outcomes were the interinjection interval and the need for clean intermittent self-catheterization.After intradetrusor botulinum neurotoxin type A injections there was significant improvement in quality of life, which was sustained after repeat injections. Mean Urogenital Distress Inventory and Incontinence Impact Questionnaire scores decreased from 56 to 26 and 59 to 21 after injection 1 in 81 patients, from 52 to 30 and 51 to 24 after injection 2 in 24, from 40 to 19 and 43 to 17 after injection 3 in 13, from 44 to 17 and 61 to 15 after injection 4 in 6 and from 51 to 17 and 63 to 14 after injection 5 in 4, respectively. The median interinjection interval was 15, 12, 14 and 13 months between injections 1 and 2, 2 and 3, 3 and 4, and 4 and 5, respectively. Considering a post-void residual urine of greater than 100 ml with lower urinary tract symptoms as the indication for clean intermittent self-catheterization, the overall clean intermittent self-catheterization rate after treatment was 43%.Intradetrusor botulinum neurotoxin type A injections for refractory idiopathic detrusor overactivity significantly improved quality of life. This effect was sustained after repeat injection. More than 2 of 5 patients with refractory idiopathic detrusor overactivity required clean intermittent self-catheterization after botulinum neurotoxin type A injections and all prospective patients should be informed about this.
The Non-Uniform Distribution of Albumin in Human and Bovine Cornea (1997)

In our previous studies, we noted a non-uniform distribution of protein tracer preferentially entering the anterior stromal lamellae of the cornea from the limbus. Given other differences reported previously between the anterior and posterior lamellae of the cornea, and the number of corneal disorders in which abnormalities are preferentially confined to either the anterior or posterior lamellae, we were prompted to examine the distribution of albumin in normal human and bovine cornea. The distribution of albumin in bovine and human cornea was studied immunohistochemically. Total soluble protein and albumin in the anterior 1/3 and posterior 2/3 of the central, middle and peripheral cornea of bovine eyes was measured biochemically. To aid in interpreting the findings, a theoretical model was developed based upon the combined effects of diffusive and convective transport. Using immunohistochemical methods, in both bovine and human eyes, intense staining of albumin was found in the anterior 1/3 of the corneal stroma. There was a gradual reduction in staining intensity from the limbus to the central cornea in the anterior corneal stroma. Less staining was found in the posterior 2/3 of corneal stroma. Additionally, a greater concentration of soluble protein and albumin was found in the anterior stroma than in the posterior stroma of the bovine eyes by biochemical analyses. The theoretical model demonstrated that this distribution of protein required a difference in excluded volume fraction between the anterior and posterior stroma and was consistent with a convective flux originating at the limbus and passing through the corneal stroma. The soluble proteins of the bovine and human cornea are preferentially concentrated in the anterior cornea and near the limbus. This distribution is likely due to differences in excluded volume fraction between the anterior and posterior stroma and a small convective flux passing through the cornea.
Robust wireless transmission scheme for scalable video streaming (2008)

An adaptive unequal loss protection (ULP) scheme for scalable video streaming over wireless networks was proposed. Based on the available network bandwidth and the packet loss rate estimation, unequal amounts of FEC protec- tion were assigned to each layer and the sending rate was determined by dynamically selecting the number of layers to transmit. To restrain the video transmission error propagation, the FEC assignment algorithm for the base layer was de- veloped by exploring the unequal importance existing in different frames of a group of pictures (GOP), and unequal amounts of protection were allocated to different base layers of a GOP in order to minimize the decoder distortion. The experiment results show that the proposed scheme can largely improve the error resilience of the scalable video bit stream and the performance of video streaming network transmission system.
Complex permittivity measurements of dielectrics and semiconductors at millimeter waves with high power sources (2005)

We present complex dielectric permittivity measurements of various semiconductor and dielectric materials, including highly absorbing substances, in Q-, V- and W-band frequencies. The measurements have been done using broadband quasioptical millimeter wave system with a backward-wave oscillator as a high power source of radiation. Frequency dependencies of real and imaginary parts of dielectric permittivity are calculated from the transmittance spectra. Complex dielectric permittivity data, obtained using both waveguide bridge technique and free space measurements have been compared with previously published results.
Crossroads (2017)

For autonomous vehicles, intelligent autonomous intersection management will be required for safe and efficient operation. In order to achieve safe operation despite uncertainties in vehicle trajectory, intersection management techniques must consider a safety buffer around the vehicles. For truly safe operation, an extra buffer space should be added to account for the network and computational delay caused by communication with the Intersection Manager (IM). However, modeling the worst-case computation and network delay as additional buffer around the vehicle degrades the throughput of the intersection. To avoid this problem, AIM[1], a popular state-of-the-art IM, adopts a query-based approach in which the vehicle requests to enter at a certain arrival time dictated by its current velocity and distance to the intersection, and the IM replies yes/no. Although this solution does not degrade the position uncertainty, it ultimately results in poor intersection throughput. We present Crossroads, a time-sensitive programming method to program the interface of a vehicle and the IM. Without requiring additional buffer to account for the effect of network and computational delay, Crossroads enables efficient intersection management. Test results on a 1/10 scale model of intersection using TRAXXAS RC cars demonstrates that our Crossroads approach obviates the need for large buffers to accommodate for the network and computation delay, and can reduce the average wait time for the vehicles at a single-lane intersection by 24%. To compare Crossroads with previous approaches, we perform extensive Matlab simulations, and find that Crossroads achieves on average 1.62X higher throughput than a simple VT-IM with extra safety buffer, and 1.36X better than AIM.
Controlling plasmonic hot spots by interfering Airy beams (2012)

We predict and demonstrate the generation of a plasmonic hot spot on the surface of a metal film by the interference of two Airy surface plasmons. We show that the position of the hot spot can be controlled by the distance between the excitation gratings as well as by the phase front of the initial excitation. The observed effect constitutes a planar analogy to Airy beam autofocusing and offers new opportunities for spatially resolved surface plasmon sensing and optical surface tweezers.
Anomalous Chiral Transfer: Supramolecular Polymerization in a Chiral Medium of a Mesogenic Molecule (2022)

Here, we report a medium-to-polymer anomalous chiral transfer in the supramolecular polymerization of a tetraphenylporphyrin-based achiral hydrogen-bonding monomer (TPP) in a chiral medium of 5-cyanobiphenyl CB*. A mixture of TPP in (R)-CB* ([TPP]=7.7 mol %) at 40 °C gave a columnar oblique LC mesophase, where the individual columns were composed of an optically active helical supramolecular polymer of TPP as a consequence of a successful medium-to-polymer chiral transfer. Meanwhile, upon dilution of CB* with achiral 5-cyanobiphenyl CB, the optical activity of the system showed an anomalous bell-shaped dependency on the composition of CB*/CB, where the g<sub>abs</sub> value of 0.049 at CB*/CB=50/50 was 6.0 times larger than the g<sub>abs</sub> value of CB* alone. Such anomalous chiroptical amplification in CD is most likely due to a change in the stacking geometry of TPP in the oblique columnar LC upon lateral compression.
Introduction of Asian Soybean Rust Urediniospores into the Midwestern United States—A Case Study (2006)

In 2005, weekly rain samples collected at 124 National Atmospheric Deposition Program/National Trends Network (NADP/NTN) sites in the eastern and central United States were screened for Asian soybean rust (ASR; Phakopsora pachyrhizi) urediniospores. Application of a quantitative polymerase chain reaction method detected P. pachyrhizi DNA in the filter residue of rain samples collected during the week of 19 to 26 July 2005 in Minnesota, Missouri, and South Dakota. To determine the geographic origin of ASR urediniospores in those weekly composite samples, back air trajectories of the lifted condensation and mixed boundary layers were calculated for each rain event within the week, by sampling site. The calculations, based on the hybrid single-particle lagrangian integrated trajectory model, pointed to source areas in eastern and southern Texas. In a separate case, DNA of P. pachyrhizi was detected in a 28 June to 5 July 2005 rain sample from an eastern Texas site. Back trajectories pointed to southern Texas and the Yucatan Peninsula in Mexico as potential source areas of ASR urediniospores. Vertical motions of those back trajectories indicated a ventilation of the boundary layer in the upwind areas, suggesting the possible injection of urediniospores into the free troposphere where they can be transported for long distances before wet deposition.
ChemInform Abstract: Stereospecific Asymmetric N‐Heterocyclic Carbene (NHC)‐Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights. (2014)

Abstract In the presence of the chiral chloride (NHC), α‐aroyloxyaldehydes undergo stereoselective cyclization with (E)‐ and (Z)‐trifluoromethyl enones to afford syn‐ and anti‐dihydropyranones.
A structural transition in class II major histocompatibility complex proteins at mildly acidic pH. (1996)

Peptide binding by class II major histocompatibility complex proteins is generally enhanced at low pH in the range of hydrogen ion concentrations found in the endosomal compartments of antigen-presenting cells. We and others have proposed that class II molecules undergo a reversible conformational change at low pH that is associated with enhanced peptide loading. However, no one has previously provided direct evidence for a structural change in class II proteins in the mildly acidic pH conditions in which enhanced peptide binding is observed. In this study, susceptibility to denaturation induced by sodium dodecyl sulfate (SDS) detergent or heat was used to probe the conformation of class II at different hydrogen ion concentrations. Class II molecules became sensitive to denaturation at pH 5.5-6.5 depending on the allele and experimental conditions. The observed structural transition was fully reversible if acidic pH was neutralized before exposure to SDS or heat. Experiments with the environment-sensitive fluorescent probe ANS (8-anilino-1-naphthalene-sulfonic acid) provided further evidence for a reversible structural transition at mildly acidic pH associated with an increase in exposed hydrophobicity in class II molecules. IAd conformation was found to change at a higher pH than IEd, IEk, or IAk, which correlates with the different pH optimal for peptide binding by these molecules. We conclude that pH regulates peptide binding by influencing the structure of class II molecules.
Antibody-Based Therapies in Multiple Myeloma (2011)

The unmet need for improved multiple myeloma (MM) therapy has stimulated clinical development of monoclonal antibodies (mAbs) targeting either MM cells or cells of the bone marrow (BM) microenvironment. In contrast to small-molecule inhibitors, therapeutic mAbs present the potential to specifically target tumor cells and directly induce an immune response to lyse tumor cells. Unique immune-effector mechanisms are only triggered by therapeutic mAbs but not by small molecule targeting agents. Although therapeutic murine mAbs or chimeric mAbs can cause immunogenicity, the advancement of genetic recombination for humanizing rodent mAbs has allowed large-scale production and designation of mAbs with better affinities, efficient selection, decreasing immunogenicity, and improved effector functions. These advancements of antibody engineering technologies have largely overcome the critical obstacle of antibody immunogenicity and enabled the development and subsequent Food and Drug Administration (FDA) approval of therapeutic Abs for cancer and other diseases.
Waveform Optimization for Near-Field Wireless Powered Communication Using a Coil Array (2020)

Driven by the growing number of Internet of Things (IoT) devices, there is a pressing need for powering devices wirelessly while communicating with them. This paper considers wireless powered communication (WPC) using near-field inductive coupling, a technique to communicate with remote devices that do not have batteries or a power supply. While near-field WPC has long been used for passive radio-frequency identification (RFID) systems, the performances of communication and power transfer have not been fully analyzed. This paper models near-field WPC using a coil array based on an abstract circuit model in which the characteristics of mutual coupling and other linear effects are captured by a small number of parameters. We investigate how the choices of load impedances and source voltages affect the performance of power transfer and communication. The improvement in power and information transfer are verified by simulation.
A laboratory investigation of a multigas monitor for anaesthesia (EMMA) (1982)

A new volatile anaesthetic gas analyser (EMMA) was tested in the laboratory. It was shown to have an accurate, linear response, with minimal zero drift and to be almost unaffected by carrier gases. It is a versatile and sensitive machine with a fast response time indicating that it might be used for breath-by-breath monitoring. The EMMA is a useful new anaesthetic gas analyser than should find widespread clinical usage.
Coherent combination of high-power, zigzag slab lasers (2006)

We demonstrate a scalable architecture for a high-power, high-brightness, solid-state laser based on coherent combinations of master oscillator power amplifier chains. A common master oscillator injects a sequence of multikilowatt Nd:YAG zigzag slab amplifiers. Adaptive optics correct the wavefront of each amplified beamlet. The beamlets are tiled side by side and actively phase locked to form a single output beam. The laser produces 19 kW with beam quality <2x diffraction limited. To the best of our knowledge, this is the brightest cw solid-state laser demonstrated to date.
Reclassification of Pediococcus urinaeequi (ex Mees 1934) Garvie 1988 as Aerococcus urinaeequi comb. nov. (2005)

The taxonomic status of Pediococcus urinaeequi is described, and the transfer of the species to the genus Aerococcus with the name Aerococcus urinaeequi comb. nov. is proposed, on the basis of the analysis of 16S rRNA gene sequence and DNA-DNA hybridization data.
Band Excitations in CePd$_3$: A Comparison of Neutron Scattering and ab initio Theory (2016)

Intermediate valence compounds containing rare earth or actinide ions are archetypal systems for the investigation of strong electron correlations. Their effective electron masses of 10 to 50 times the free electron mass result from a hybridization of the highly localized $f$-electrons with the more itinerant $d$-electrons, which is strong enough that their properties are dominated by on-site electron correlations. To a remarkable degree, this can be modeled by the Anderson Impurity Model, even though the $f$-electrons are situated on a periodic lattice. However, in recent years, there has been increasing evidence that the dynamic magnetic susceptibility of intermediate valence compounds is not purely local, but shows variations across the Brillouin zone that have been ascribed to $f$-band coherence. So far, this has been based on simplified qualitative models. In this article, we present a quantitative comparison of inelastic neutron scattering from a single crystal of CePd$_3$, measured in four-dimensional (Q,$ω$)-space, with ab initio calculations, which are in excellent agreement on an absolute scale. Our results establish that the Q-dependence of the scattering is caused by particle-hole excitations within $f$-$d$ hybridized bands that grow in coherence with decreasing temperature.
A Phase 2 Study Evaluating the Efficacy and Safety of a Novel, Proprietary, Nano-Formulated, Lower Dose Oral Diclofenac (2012)

Lower dose, nano-formulated diclofenac demonstrated good overall efficacy, prompt pain relief, and was well tolerated. These data suggest lower dose nano-formulated NSAIDs could be effective for acute pain and may potentially improve safety and tolerability as a result of using a lower overall dose.
Perspectives in the Medical Treatment of Glaucoma (1982)

In the last ten years at least three developments in ophthalmic pharmacology have prompted a fresh interest in both the mechanism of action of drugs in glaucoma and in new approaches to glaucoma therapy on the part of both pharmacologists and ophthalmologists. One is the dramatic reduction in eye pressure and aqueous inflow produced by beta adrenergic blockers, especially timolol. The second is a new emphasis on drug delivery systems and pharmacokinetics. The third is the finding, at least in the USA., of the prevalence of secondary glaucomas compared to primary glaucomas.