gebhart/patrepeval huggingface dataset:
Selenium Assimilation and Volatilization from Selenocyanate-Treated Indian Mustard and Muskgrass (2002)

Selenocyanate (SeCN(-)) is a major contaminant in the effluents from some oil refineries, power plants, and in mine drainage water. In this study, we determined the potential of Indian mustard (Brassica juncea) and muskgrass (a macroalga, Chara canescens) for SeCN(-) phytoremediation in upland and wetland situations, respectively. The tolerance of Indian mustard to toxic levels of SeCN(-) was similar to or higher than other toxic forms of Se. Indian mustard treated with 20 microM SeCN(-) removed 30% (w/v) of the Se supplied in 5 d, accumulating 554 and 86 microg of Se g(-1) dry weight in roots and shoots, respectively. Under similar conditions, muskgrass removed approximately 9% (w/v) of the Se supplied as SeCN(-) and accumulated 27 microg of Se g(-1) dry weight. A biochemical pathway for SeCN(-) degradation was proposed for Indian mustard. Indian mustard and muskgrass efficiently degraded SeCN(-) as none of the Se accumulated by either organism remained in this form. Indian mustard accumulated predominantly organic Se, whereas muskgrass contained Se mainly as selenite and organic Se forms. Indian mustard produced volatile Se from SeCN(-) in the form of less toxic dimethylselenide. Se volatilization by Indian mustard accounted for only 0.7% (w/v) of the SeCN(-) removed, likely because the biochemical steps in the production of dimethylselenide from organic Se were rate limiting. Indian mustard is promising for the phytoremediation of SeCN(-) -contaminated soil and water because of its remarkable abilities to phytoextract SeCN(-) and degrade all the accumulated SeCN(-) to other Se forms.
Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory (2011)

Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) was originally identified in patients with seizures. It is densely distributed in the hip-pocampus and amygdala in particular. Because the expression of Arc/Arg3.1 is regulated by nerve in-puts, it is thought to be an immediate early gene. As shown both in vitro and in vivo, Arc/Arg3.1 is in-volved in synaptic consolidation and regulates some forms of learning and memory in rats and mice [1,2]. Furthermore, a recent study suggests that Arc/Arg3.1 may play a significant role in signal transmission via AMPA-type glutamate receptors [3-5]. Therefore, we conducted a detailed analysis of fear memory in Arc/Arg3.1-deficient mice. As previously reported, the knockout animals exhib-ited impaired fear memory in both contextual and cued test situations. Although Arc/Arg3.1-deficient mice showed almost the same performance as wild-type littermates 4 hr after a conditioning trial, their performance was impaired in the retention test after 24 hr or longer, either with or without reconsolidation. Immunohistochemical analyses showed an abnormal density of GluR1 in the hip-pocampus of Arc/Arg3.1-deficient mice; however, an application of AMPA potentiator did not improve memory performance in the mutant mice. Memory impairment in Arc/Arg3.1-deficient mice is so ro-bust that the mice provide a useful tool for devel-oping treatments for memory impairment.
Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations (2021)

These results suggest that composition of fatty acids in polysorbate 80 may be a promoter for sub-visible particulate formation under the stress conditions tested but may not impact protein aggregation or biological activity.
How Would Patients Behave If They Were Continually Informed of Their Blood Glucose Levels? A Simulation Study Using a “Virtual” Patient (2008)

With the continuous measurement of their actual BG, subjects could reduce the frequency of hypoglycemia by 50% but increased the number of unnecessary interventions (excess carbohydrate intake or prematurely without a real hypoglycemia threat). Hyperglycemia prevention is a more difficult task. Simulation with an in silico disease model is a realistic alternative to studies in patients. A simulation program such as DIABLOG could be valuable for education in order to more rapidly and reliably recognize impending hypo- and hyperglycemia episodes.
The reaction of pyrroles with trimethylhalosilanes‐dialkyl sulfoxides (1993)

Abstract Pyrroles are powerful nucleophiles in the reaction with dialkyl sulfoxides and trimethylchlorosilane (TMCS) or trimethylbromosilane (TMBS), affording sulfonium salts or halo derivatives, generally in good yields.
Abstract 2532: High expression of MiR-432-3p is associated with the chemoresistance by NRF2 stabilization via directly targeting KEAP1 (2017)

Abstract NF-E2-related factor 2 (NRF2) is a master transcriptional regulator that integrates cellular stress responses and is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1) at the post-translational level. In human cancers, aberrantly stabilized NRF2, either by mutation of NRF2 or KEAP1, plays a vital role in chemoresistance through the activation of target genes, suggesting that targeted inhibition of NRF2 is a potential therapy for NRF2-stabilized tumors. MicroRNAs (miRNA) are endogenous small noncoding RNAs that can negatively regulate gene expression by interfering with the translation or stability of target transcripts. Previously, we identified miRNAs negatively regulating NRF2 pathway via directly targeting NRF2 itself by a reporter-coupled miRNA library screening and demonstrated the potential of miRNA-based therapy against NRF2-stabilized tumors in esophageal squamous cell carcinoma (ESCC) (Mol. Cancer Res 2014, Cancer Res 2015). In the present study, we further identified miR-432-3p as a miRNA positively regulating NRF2 pathway. MiR-432-3p could directly targeted KEAP1 via binding to its seed sequence within the cording region. Overexpression of miR-432-3p resulted in enhanced resistance to cisplatin via activation of NRF2 in ESCC cell lines. Furthermore, miR-432-3p was overexpressed in 55 of 84 primary ESCC tumors, compared with that of corresponding non-cancerous esophageal mucosa (65.5%). Importantly, we showed the negative correlation between the expression level of KEAP1 and miR-432-3p in primary ESCC tumors. Taken together, these findings suggest that the high expression of miR-432-3p may contribute to the chemoresistance by NRF2 stabilization via down-regulation of KEAP1 expression in ESCC. Citation Format: Burak Akdemir, Jun Inoue, Tatsuyuki Kawano, Johji Inazawa. High expression of MiR-432-3p is associated with the chemoresistance by NRF2 stabilization via directly targeting KEAP1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2532. doi:10.1158/1538-7445.AM2017-2532
Bildung von enantiomerenangereicherten Lithiumindeniden mit (−)‐Spartein — Strukturen, stereospezifische Substitution, Einfluß des Lösungsmittels (1995)

Auf der thermodynamisch kontrollierten Einstellung des Gleichgewichts zwischen den konfigurationslabilen diastereomeren Li‐1‐Alkylindenid/(−)‐Spartein‐Komplexen 1 in Diethylether/Hexan, verbunden mit der Kristallisation des begünstigten Komplexes (nur dieses Diastereomer gezeigt; R = Me, n Bu) beruht die zum Teil sehr gute enantio‐faciale Differenzierung am Indenidrest bei der Addition dieser Komplexe an Carbonylverbindungen. Wird die Reaktion in THF/Hexan durchgeführt, verdrängen THF‐Moleküle den chiralen Liganden, und es werden racemische Produkte erhalten. magnified image
Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues (2010)

Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.
Mangosteen Concentrate Drink Supplementation Promotes Antioxidant Status and Lactate Clearance in Rats after Exercise (2020)

High-strength or long-duration exercise can lead to significant fatigue, oxidative stress, and muscle damage. The purpose of this study was to examine the effect of mangosteen concentrate drink (MCD) supplementation on antioxidant capacity and lactate clearance in rats after running exercise. Forty rats were divided into five groups: N, non-treatment; C, control; or supplemented with MCD, including M1, M5, and M10 (0.9, 4.5, and 9 mL/day) for 6 weeks. The rats were subjected to 30 min running and exhaustive-running tests using a treadmill. The blood lactate; triglyceride; cholesterol and glucose levels; hepatic and muscular malonaldehyde (MDA) levels; and antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), were analyzed. The results of this study demonstrated that MCD supplementation can increase GPx and CAT activities, alleviate oxidative stress in muscle, and increase lactate clearance, and is thereby beneficial to reduced muscle fatigue after exercise.
Human Brain (1978)

The auditory regions in four normal brains were mapped and the full extent of the cytoarchitectonic subdivisions was measured for the presence of right-left asymmetries. It was found that asymmetries similar to those found in the planum temporale (left commonly larger than right) are also seen in auditory cytoarchitectonic area Tpt, and area of probable importance for language function. There is a strong positive correlation between the planum asymmetry and the asymmetry of Tpt. It is concluded that the previously described planum asymmetries probably reflect asymmetries in an auditory cytoarchitectonic area and therefore may represent, at least in part, the anatomic substrate for language lateralization.
T-wave inversion and mortality risk (2015)

TWI is a strong predictor for CHD, CVD, and all-cause mortality in the general population. The respective risks of CHD and CVD among men with TWI were also increased among men with high blood pressure, LDL cholesterol, and obesity.
Aberrations of MYC Are a Common Event in B-Cell Prolymphocytic Leukemia (2014)

These results suggest that deregulation of MYC plays an important role in the pathogenesis of B-PLL and expands the spectrum of B-cell neoplasms associated with aberrations of MYC.
Phenolic content and antibacterial activity of olive oil waste waters (1992)

Abstract The antibacterial effects of olive oil wastes from traditional installations (TM), wastes from modern installations (CM), and wastes from an evaporation pool (EP) were assayed with a soil bacterium (Bacillus megaterium ATCC 33085). Irrespective of the origin, fresh wastes showed higher antimicrobial activity than those from evaporation pools. Among several extractants, ethyl acetate and n-propanol were the most effective organic solvents in the recovery of the antimicrobial activity from wastes. No antimicrobial activity was recovered by hexane extraction. Extracts from evaporation pool wastes showed no antibacterial activity. A good correlation between phenolic content and antimicrobial activity was found.
Power-based Side-Channel Instruction-level Disassembler (2018)

Modern embedded computing devices are vulnerable against mal-ware and software piracy due to insufficient security scrutiny and the complications of continuous patching. To detect malicious activity as well as protecting the integrity of executable software, it is necessary to monitor the operation of such devices. In this paper, we propose a disassembler based on power-based side-channel to analyze the real-time operation of embedded systems at instruction-level granularity. The proposed disassembler obtains templates from an original device (e.g., IoT home security system, smart thermostat, etc.) and utilizes machine learning algorithms to uniquely identify instructions executed on the device. The feature selection using Kullback-Leibler (KL) divergence and the dimensional reduction using PCA in the time-frequency domain are proposed to increase the identification accuracy. Moreover, a hierarchical classification framework is proposed to reduce the computational complexity associated with large instruction sets. In addition, covariate shifts caused by different environmental measurements and device-to-device variations are minimized by our covariate shift adaptation technique. We implement this disassembler on an AVR 8-bit microcontroller. Experimental results demonstrate that our proposed disassembler can recognize test instructions including register names with a success rate no lower than 99.03% with quadratic discriminant analysis (QDA).
Lentinus edodes: A Macrofungus with Pharmacological Activities (2010)

Lentinus edodes is the first medicinal macrofungus to enter the realm of modern biotechnology. It is the second most popular edible mushroom in the global market which is attributed not only to its nutritional value but also to possible potential for therapeutic applications. Lentinus edodes is used medicinally for diseases involving depressed immune function (including AIDS), cancer, environmental allergies, fungal infection, frequent flu and colds, bronchial inflammation, heart disease, hyperlipidemia (including high blood cholesterol), hypertension, infectious disease, diabetes, hepatitis and regulating urinary inconsistencies. It is the source of several well-studied preparations with proven pharmacological properties, especially the polysaccharide lentinan, eritadenine, shiitake mushroom mycelium, and culture media extracts (LEM, LAP and KS-2). Antibiotic, anti-carcinogenic and antiviral compounds have been isolated intracellularly (fruiting body and mycelia) and extracellularly (culture media). Some of these substances were lentinan, lectins and eritadenine. The aim of this review is to discuss the therapeutic applications of this macrofungus. The potential of this macrofungus is unquestionable in the most important areas of applied biotechnology.
Investigation, development and experimental analyses of a heat pipe based battery thermal management system (2019)

In this paper, the performance of a heat pipe based thermal management technique for batteries has been investigated experimentally. In this regard, a test rig was developed and used to demonstrate the effectiveness of flat heat pipe (heat mat) technology at controlling and maintaining the temperature of a prototype battery module, which consisted of sixteen prismatic lithium-titanate (LTO) cells. Test results were obtained which proved the ability of the technology to keep the battery cells at an optimal temperature, during cycling representative of real-world operation, from either a cold or hot start. The heat mat was shown to efficiently absorb the heat generated by the cells and transfer it effectively to an external cooling medium of either water or refrigerant. In conclusion, it was demonstrated that the maximum cell temperature is significantly reduced and the overall temperature uniformity of the module is greatly improved, when compared to a module with no thermal management. The maximum cell temperature was kept below 28 °C and the module temperature uniformity was maintained at +/−1 °C. By using test cycles that generated a quasi-steady-state heat load from the cells, it was shown that approximately 60% of the heat generated by the cells was removed by the heat mat. The results obtained from this work demonstrate that heat mat technology can improve battery performance and longevity by reducing the degradation and ageing process and cell imbalances, that result from high cell temperatures and module/pack-level temperature non-uniformity.
3.25.1HEAT EXCHANGERS WITH DIMPLED SURFACES: INTRODUTION: DIMPLED SURFACES FOR HEAT EXCHANGERS (2006)

Sections 3.25.1-3.25.6 Insert the new Sections in the folder for Part 3 following Section 3.24.
ChemInform Abstract: Corniculoside, a New Biosidic Ester Secoiridoid from Halenia corniculata. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Elimination of Interference by Phenazopyridine Hydrochloride ("Pyridium") in Determining Ethchlorvynol("Placidyl") (1973)

Journal Article Elimination of Interference by Phenazopyridine Hydrochloride ("Pyridium") in Determining Ethchlorvynol("Placidyl") Get access Christopher S Frings, Christopher S Frings Medical Laboratory Associates 1025 S. 18th St. Birmingham, Ala. 35205 Search for other works by this author on: Oxford Academic Google Scholar Cecelia A Queen Cecelia A Queen Medical Laboratory Associates 1025 S. 18th St. Birmingham, Ala. 35205 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 19, Issue 9, 1 September 1973, Page 1087, https://doi.org/10.1093/clinchem/19.9.1087 Published: 01 September 1973
Status of Biological hydrogen production (2011)

This paper analyzes yields, reaction rates and reactor designs, and compares effectiveness of different substrate-microorganism combinations. Net energy analysis of processes reveals directions for viability and screening of options. Techniques like metabolic flux analysis can be used to establish targets for increased yields. Factors influencing production and possibility of using genetic engineering to increase production rates are discussed. The paper identifies gaps and possible directions for future development of biological hydrogen production.
Some neurobiological aspects of psychotherapy. A review. (1999)

Ever since the idea was accepted that memory is associated with alterations in synaptic strength, studies on the cellular and molecular mechanisms responsible for the plastic changes in neurons have attracted wide interest in the scientific community. This article explores the process of memory consolidation leading to persistent modifications in synaptic plasticity as a mechanism by which psychotherapy facilitates changes in the permanent storage of information acquired throughout the individual's life. The psychobiological interrelationships of affect, attachment, and memory offer a perspective regarding the etiology and treatment of clinical disturbances of affect. Analogies between brain physiology and modes of psychotherapy provide the foundation for a review of psychiatric disorders involving the inability to control fear, obsessions, compulsions, and delusions, all of which respond to psychotherapeutic interventions.(The Journal of Psychotherapy Practice and Research 1999; 8:103–114)
A STUDY OF THE INFLUENCE OF VISUAL SETTINGS ON THE EVALUATION OF TOWNSCAPE USING SLIDE PICTURES (2003)

This study explored how subjective evaluation of townscape are influenced by presentation settings such as the size of the picture on screen, the distance between screen and observer and the angle of view of the picture. Experiments of townscape evaluation with several presentation settings were held, and following results are obtained : 1) The size of picture have little influence on almost all rating scales. 2) The distance between screen and observer have strong influence on the rating score of spaciousness and activity, however it have small influence on scales such as preference, beauty and harmonious. 3) Smaller viewing angle than real situation make the area of point of attention wider in the frame of picture.
Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone (2001)

Use of non-steroidal anti-inflammatory drugs (NSAIDs) for chemoprevention of colon cancer has been hindered by their potential gastro-intestinal toxicity. Nabumetone, which is approximately 10 to 36 times safer than conventional NSAIDs, was evaluated in 2 models of experimental colon carcinogenesis. In azoxymethane (AOM)-treated Fisher 344 rats, nabumetone caused dose-dependent inhibition of aberrant crypt foci (ACF), with 750 and 1,500 ppm resulting in 15% and 37% reductions, respectively (p < 0.05). Moreover, complex ACF were reduced by 48% in the latter group. MIN mice studies confirmed the chemopreventive efficacy of nabumetone, with 900 ppm suppressing approximately half of the intestinal tumors. Interestingly, inhibition of intermediate biomarkers in both models was markedly greater in the distal than the proximal bowel. To mechanistically evaluate this regional selectivity, we assessed cyclo-oxygenase-2 (COX-2) expression in the uninvolved mucosa and demonstrated a 3- to 4-fold excess in the distal relative to the proximal bowel in both MIN mice and AOM-treated rats. We then investigated another putative NSAID target, peroxisome proliferator-activated receptor-delta (PPAR-delta) and demonstrated up-regulation during AOM-induced colonic tumorigenesis. Furthermore, in pre-neoplastic mucosa, there was a 3-fold excess of PPAR-delta in the distal colon. We demonstrate that nabumetone is an effective protective agent in both experimental models of colon carcinogenesis. The striking distal predilection of nabumetone may be, at least partially, explained by distal bowel over-expression of COX-2 and PPAR-delta.
Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies (2022)

Greater illness severity and cardiovascular involvement in the OC-19 cohort compared with the BATS cohort, and not use of different MIS-C case definitions, may have contributed to differing study conclusions about optimal initial treatment for MIS-C. Disease severity should be considered in future MIS-C study designs and treatment recommendations to identify patients who would benefit from aggressive immunomodulatory treatment.
Latent Space Oddity: on the Curvature of Deep Generative Models (2017)

Deep generative models provide a systematic way to learn nonlinear data distributions, through a set of latent variables and a nonlinear "generator" function that maps latent points into the input space. The nonlinearity of the generator imply that the latent space gives a distorted view of the input space. Under mild conditions, we show that this distortion can be characterized by a stochastic Riemannian metric, and demonstrate that distances and interpolants are significantly improved under this metric. This in turn improves probability distributions, sampling algorithms and clustering in the latent space. Our geometric analysis further reveals that current generators provide poor variance estimates and we propose a new generator architecture with vastly improved variance estimates. Results are demonstrated on convolutional and fully connected variational autoencoders, but the formalism easily generalize to other deep generative models.
Swelling and Diffusion in Polymerized Ionic Liquids-Based Hydrogels (2021)

Hydrogels are one of the emerging classes of materials in current research. Besides their numerous applications in the medical sector as a drug delivery system or in tissue replacement, they are also suitable as irrigation components or as immobilization matrices in catalysis. For optimal application of these compounds, knowledge of the swelling properties and the diffusion mechanisms occurring in the gels is mandatory. This study is focused on hydrogels synthesized by radical polymerization of imidazolium-based ionic liquids. Both the swelling and diffusion behavior of these hydrogels were investigated via gravimetric swelling as well as sorption experiments implemented in water, ethanol, <i>n</i>-heptane, and tetrahydrofuran. In water and ethanol, strong swelling was observed while the transport mechanism deviated from Fickian-type behavior. By varying the counterion and the chain length of the cation, their influences on the processes were observed. The calculation of the diffusion coefficients delivered values in the range of 10<sup>-10</sup> to 10<sup>-12</sup> m<sup>2</sup> s<sup>-1</sup>. The gravimetric results were supported by apparent diffusion coefficients measured through diffusion-weighted magnetic resonance imaging. A visualization of the water diffusion front within the hydrogel should help to further elucidate the diffusion processes in the imidazolium-based hydrogels.