gebhart/patrepeval huggingface dataset:
Pictorial review Percutaneous vertebroplasty: indications, contraindications, and technique (2003)

Percutaneous vertebroplasty is an emerging interventional technique in which surgical polymethyl- methacrylate is injected via a large bore needle into a vertebral body under imaging guidance. This technique provides increased strength and pain relief in vertebrae weakened by a variety of bone diseases. The current indication for vertebroplasty is intractable non-radicular pain caused by compression fractures due to osteoporosis, myeloma, metastases and aggressive vertebral haemangioma. Contraindications include bleeding disorder, unstable fracture and lack of definable vertebral collapse. Our technique of percutaneous vertebro- plasty is illustrated in this pictorial review. Percutaneous vertebroplasty, first described in 1987, is a radiologically guided procedure in which percutaneous injection of polymethylmethacrylate (PMM), a surgical bone cement, is injected into a vertebra under imaging guidance. This procedure has become increasingly accepted as a treatment option in patients with intractable back pain due to vertebral compression fractures. Over a 38 month period, since commencement of the procedure in June 1998, 482 percutaneous vertebroplasties have been performed in 244 treatment sessions on 213 consecutive patients at the Mallinckrodt Institute of Radiology, St Louis, MO. This pictorial essay aims to review and illustrate the indications, contraindications and our technique for performing this procedure. The potential complications and expected clinical outcome are also briefly reviewed.
Through The Wall Respiration Rate Detection Using Hilbert Vibrational Decomposition (2018)

In this paper, a simple direct demodulation Doppler radar is proposed to detect the respiration rate through the wall using Hilbert vibration decomposition (HVD) at 2.4 GHz. For through the wall detection of the human subject, the measurements are taken by varying the respiration rate, with different positions of human subject with respect to the radar and different background behind the human subject. This method is suitable for the detection of human subject in natural calamities or disasters. Using this method, through the wall respiration rate of human subject can be detected up to 2–3 meter.
Inhibition of Human Napsin A (2003)

The newly-discovered human aspartic proteinase, napsin A was not susceptible to protein inhibitors from potato, squash or yeast but was weakly inhibited by the 17 kDa polypeptide from Ascaris lumbricoides and potently by isovaleryl and lactoyl-pepstatins. A series of synthetic inhibitors was also investigated which contained in the P(1)-P(1)' positions the dipeptide analogue statine or its phenylalanine or cyclohexylalanine homologues and in which the residues occupying P(4)-P(3)' were varied systematically. On this basis, the active site of napsin A can be readily distinguished from other human aspartic proteinases.
Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: A genotype-phenotype study (2011)

Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene. To study genotype-phenotype correlations, we evaluated the clinical and laboratory data of 51 genetically proven A-T patients, and additionally measured ATM protein expression and kinase activity. Patients without ATM kinase activity showed the classical phenotype. The presence of ATM protein, correlated with slightly better immunological function. Residual kinase activity correlated with a milder and essentially different neurological phenotype, absence of telangiectasia, normal endocrine and pulmonary function, normal immunoglobulins, significantly lower X-ray hypersensitivity in lymphocytes, and extended lifespan. In these patients, cancer occurred later in life and generally consisted of solid instead of lymphoid malignancies. The genotypes of severely affected patients generally included truncating mutations resulting in total absence of ATM kinase activity, while patients with milder phenotypes harbored at least one missense or splice site mutation resulting in expression of ATM with some kinase activity. Overall, the phenotypic manifestations in A-T show a continuous spectrum from severe classical childhood-onset A-T to a relatively mild adult-onset disorder, depending on the presence of ATM protein and kinase activity. Each patient is left with a tremendously increased cancer risk.
Phylogenetic classification of short environmental DNA fragments (2008)

Metagenomics is providing striking insights into the ecology of microbial communities. The recently developed massively parallel 454 pyrosequencing technique gives the opportunity to rapidly obtain metagenomic sequences at a low cost and without cloning bias. However, the phylogenetic analysis of the short reads produced represents a significant computational challenge. The phylogenetic algorithm CARMA for predicting the source organisms of environmental 454 reads is described. The algorithm searches for conserved Pfam domain and protein families in the unassembled reads of a sample. These gene fragments (environmental gene tags, EGTs), are classified into a higher-order taxonomy based on the reconstruction of a phylogenetic tree of each matching Pfam family. The method exhibits high accuracy for a wide range of taxonomic groups, and EGTs as short as 27 amino acids can be phylogenetically classified up to the rank of genus. The algorithm was applied in a comparative study of three aquatic microbial samples obtained by 454 pyrosequencing. Profound differences in the taxonomic composition of these samples could be clearly revealed.
Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress (2012)

Insulin resistance is due to the reduced cellular response to insulin in peripheral tissues. The interaction of insulin with its receptor is the first step in insulin action and thus the identified target of insulin resistance. It has been well established that defects or mutations in the insulin receptor (IR) cause insulin resistance. Therefore, an IR activator might be a novel therapeutic approach for insulin resistance. Our previous report showed that mild electrical stress (MES) enhanced the insulin-induced signaling pathway. However, the molecular mechanism of the effect of MES remains unclear. We assessed the effect of MES, which is characterized by low-intensity direct current, on insulin signaling in vitro and in vivo. Here, we showed that MES activated the insulin signaling in an insulin-independent manner and improved insulin resistance in peripheral tissues of high fat-fed mice. Moreover, we found that MES increased the localization of IR in lipid rafts and enhanced the level of phosphorylated Akt in insulin-resistant hepatic cells. Ablation of lipid rafts disrupted the effect of MES on Akt activation. Our findings indicate that MES has potential as an activator of IR in an insulin-independent manner, and might be beneficial for insulin resistance in type 2 diabetes.
PO468 Management of Overweight and Obesity In Patients With Coronary Heart Disease Across 27 Countries In Europe: Results From Euroaspire IV Survey of the European Society of Cardiology (2018)

Osteoporosis is a multifactorial disease that increases in prevalence with age, and may be associated with fragility fractures. In Colombia there are few studies conducted on male osteoporosis.To describe the characteristics of men with osteoporosis who received care at the endocrinology outpatient clinic in two institutions in Manizales.Descriptive, cross-sectional study. The medical records of over 18-year old men that submitted a bone densitometry report to the endocrinology clinic from January 2009 to October 2018 were reviewed.The results of the bone densitometry studies, the frequency of the types of osteoporosis, their etiology, risk factors, and the characteristics of fragility fractures were described.A total of 417 medical records were reviewed, of which 303 met the eligibility criteria. The mean age was 66 years; 90 % of were over 50 old. Osteoporosis was diagnosed in 82.2 % of the men, with a higher frequency among those between 50 and 89 years old. 61 % had secondary osteoporosis, and the main causes were chronic use of glucocorticoids (42.1 %), hypogonadism (23.7 %), and hyperparathyroidism (16.4 %). 42.2 % presented with fragility fractures and the most common location was the spine (80 %).The diagnosis of osteoporosis was frequent among the male population in this trial; the most frequent type was secondary osteoporosis, and a significant percentage of men had fragility fractures.La osteoporosis es una enfermedad multifactorial que aumenta su prevalencia con la edad y se puede asociar a fracturas por fragilidad. En Colombia son pocos los estudios realizados sobre osteoporosis en los hombres.Describir las características de los hombres con osteoporosis que asistieron a la consulta de endocrinología en 2 instituciones de la ciudad de Manizales.Estudio descriptivo de corte transversal. Se revisaron las historias clínicas de hombres mayores de 18 años que asistieron con reporte de densitometría ósea a la consulta de endocrinología durante el período de enero de 2009 a octubre de 2018. Se describieron los resultados de las densitometrías, la frecuencia de los tipos de osteoporosis, su etiología, factores de riesgo y las características de las fracturas por fragilidad.417 historias clínicas fueron revisadas, 303 cumplieron los criterios de elegibilidad. La edad media de los hombres fue de 66 años, el 90 % estaba por encima de los 50 años. Se diagnosticó osteoporosis en el 82.2 % de los hombres; más frecuente entre los 50 a 89 años. El 61 % tenía osteoporosis secundaria y sus principales causas fueron el uso crónico de glucocorticoides (42.1 %), el hipogonadismo (23.7 %) y el hiperparatiroidismo (16.4 %). El 42.2 % presentó fracturas por fragilidad y la localización más común fue la columna vertebral (80 %).El diagnóstico de osteoporosis fue frecuente en la población de hombres del presente estudio, el tipo más común fue la secundaria y se encontró un porcentaje significativo de hombres con fracturas por fragilidad.
Carbon as Quasi-Reference Electrode in Unconventional Lithium-Salt Containing Electrolytes for Hybrid Battery/Supercapacitor Devices (2016)

Metallic lithium is the most widespread reference electrode in lithium ion battery research, but its high reactivity limits the usage primarily to conventional carbonate based electrolytes. Novel high power concepts, like hybrid supercapacitors, require lithium containing electrolytes with high ionic conductivity (e.g., acetonitrile), which are not always stable versus lithium. In the current work we face this issue by refining activated carbon as a quasi-reference electrode originally employed for conventional supercapacitors. Different commercially available carbon powders were examined as reference electrode materials and calibrated in lithium-salt containing acetonitrile versus Li+ intercalation/de-intercalation reaction of nanoparticulate Li4Ti5O12. The stability of the activated carbon reference electrode is highly affected by the salt employed and decreases in the following order: LiTFSI > LiClO4 > LiPF6 > LiBF4. Only a negligible impact of electrolyte solvent, pore size distribution and reference electrode binder was observed. Furthermore, activated carbon was functionalized (HNO3 treated) and de-functionalized (thermal annealing in vacuum or hydrogen) to investigate the impact of carbon functionalization on the reference electrode stability. Nitrogen and oxygen containing surface groups have been found to drastically improve long-term stability of activated carbon quasi-reference electrodes. Even after 15 days exposed to the electrolyte, the potential of HNO3 treated activated carbon is marginally altered by 10 mV.
Running the manual (2006)

We propose a development methodology for designing and prototyping high assurance microkernels, and describe our application of it. The methodology is based on rapid prototyping and iterative refinement of the microkernel in a functional programming language. The prototype provides a precise semi-formal model, which is also combined with a machine simulator to form a reference implementation capable of executing real user-level software, to obtain accurate feedback on the suitability of the kernel API during development phases. We extract from the prototype a machine-checkable formal specification in higher-order logic, which may be used to verify properties of the design, and also results in corrections to the design without the need for full verification. We found the approach leads to productive, highly iterative development where formal modelling, semi-formal design and prototyping, and end use all contribute to a more mature final design in a shorter period of time.
Antigenic Drift in the Ligand Domain ofPlasmodium vivaxDuffy Binding Protein Confers Resistance to Inhibitory Antibodies (2004)

Interaction of the Duffy binding protein (DBP) with its erythrocyte receptor is critical for maintaining Plasmodium vivax blood-stage infections, making DBP an appealing vaccine candidate. The cysteine-rich region II is the ligand domain of DBP and a target of vaccine development. Interestingly, most of the allelic diversity observed in DBP is due to the high rate of nonsynonymous polymorphisms in this critical domain for receptor recognition. Similar to the hypervariability in influenza hemagglutinin, this pattern of polymorphisms in the DBP ligand domain suggests that this variation is a mechanism to evade antibody neutralization. To evaluate the role that dbp allelic diversity plays in strain-specific immunity, we examined the ability of an anti-Sal1 DBP serum to inhibit the erythrocyte-binding function of variant dbp alleles expressed on COS cells. We observed that the PNG-7.18 allele was significantly less sensitive to immune inhibition of its erythrocyte-binding activity than were the Sal1 and PNG-27.16 alleles. This result suggested that the unique polymorphisms of resistant PNG-7.18 were part of a protective epitope on the DBP ligand. To confirm this, Sal1 was converted to the refractory phenotype by introduction of 3 polymorphisms unique to PNG-7.18, via site-directed mutagenesis. The results of the present study indicate that linked polymorphisms have an additive, synergistic effect on DBP antigenic character.
Demo: Recording emotions with “MyInnerLife” (2009)

Our project is a system to express emotions and record them on a long-term basis. In contrast to a lot of the research in the field of affective computing our project is not dedicated to enable machines to detect human emotions but to allow new input methods. This demo presents 'MyInnerLife', a physical input device to express and record emotions non-verbally.
Technical Note: A new phantom design for routine testing of Doppler ultrasound (2016)

The developed phantom provides stable fluid flow useful for frequent clinical Doppler ultrasound testing and attempts to address several obstacles facing Doppler phantom testing. Such an ultrasound phantom can make routine testing more approachable for institutions that wish to initiate a Doppler QA program or complement a previously existing QA program.
D13N1—A myc-associated sequence found near the TCRγ locus on mouse chromosome 13 (1989)

Journal Article D13N1—A myc-associated sequence found near the TCRγ locus on mouse chromosome 13 Get access Lila Feisee, Lila Feisee Laboratory of GeneticsBuilding 37, Room 2B21, NCI NII, Bethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Konrad Huppi Konrad Huppi Laboratory of GeneticsBuilding 37, Room 2B21, NCI NII, Bethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 24, 25 December 1989, Page 10517, https://doi.org/10.1093/nar/17.24.10517 Published: 25 December 1989
Nondestructive Sol−Gel Immobilization of Metal(salen) Catalysts in Silica Aerogels and Xerogels (2001)

Nondestructive immobilization of cobalt and copper Schiff base complexes in silica aero- and xerogels was achieved via the sol−gel method using a precursor N,N‘-ethylenebis(salicylidenaminato) (salen) ligand modified with pendant silyl ethoxy groups. Aerogels were obtained by semicontinuous extraction of the wet gels with supercritical CO2 and xerogels by conventional drying. Cobalt and copper(salen) containing silica gels were characterized by FTIR, UV−vis, and XPS spectroscopy, laser ablation-ICP-MS, and EPR studies. Aero- and xerogel incorporated salen compounds exhibited similar spectroscopic properties to cobalt/copper(salen) precursors and known metal(salen) compounds. BET measurements confirmed the importance of supercritical CO2 drying in maintaining the mesoporous structure of the aerogel. Laser ablation-ICP-MS and EPR studies of the aerogels showed that a uniform distribution of the isolated metal(salen) complex was achieved via molecular mixing using the sol−gel method. Stability of these materials was demonstrated by thermogravimetric analyses in air and leaching studies conducted under typical liquid-phase oxidation conditions. XPS analyses showed surface relative atomic concentrations in the modified gels to be similar before and following leaching studies.
Supplementary Figure 4 from Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression (2023)

Supplementary Figure 4 from Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression
Genome-wide association study in primary angle closure glaucoma (2017)

Before the Human Genome Project, family-based mapping, positional cloning and mutation screening of candidate genes were largely used to ascertain the etiology of a given genetic disease. While this method proved to be very effective for most Mendelian single-gene disorders, it was not efficient for multigenic disorders with unknown genetic etiology. Subsequent advancement in molecular genetics techniques provided an opportunity to screen millions of biological markers in thousands of patients in a relatively short period of time. One rapid technique that is already used in a large number of clinical disorders is genome-wide association study (GWAS). Other screening methods include next-generation exome sequencing, whole-genome sequencing and targeted regional sequencing.
A Method for the Preparation of RNA from Human Colonic Mucosa Obtained by Colonoscopic Biopsy (1989)

Conference Abstract| January 01 1989 A Method for the Preparation of RNA from Human Colonic Mucosa Obtained by Colonoscopic Biopsy A.J.S. MacPherson; A.J.S. MacPherson 1Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middx. and Dept. Biochemistry Charing Cross and Westminster Medical School Search for other works by this author on: This Site PubMed Google Scholar I. Bjarnason; I. Bjarnason 1Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middx. and Dept. Biochemistry Charing Cross and Westminster Medical School Search for other works by this author on: This Site PubMed Google Scholar K. Chester; K. Chester 1Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middx. and Dept. Biochemistry Charing Cross and Westminster Medical School Search for other works by this author on: This Site PubMed Google Scholar J Hammersley; J Hammersley 1Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middx. and Dept. Biochemistry Charing Cross and Westminster Medical School Search for other works by this author on: This Site PubMed Google Scholar T.J. Peters T.J. Peters 1Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middx. and Dept. Biochemistry Charing Cross and Westminster Medical School Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8736 Print ISSN: 0143-5221 © 1989 The Biochemical Society and the Medical Research Society1989 Clin Sci (Lond) (1989) 76 (s20): 27P. https://doi.org/10.1042/cs076027P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation A.J.S. MacPherson, I. Bjarnason, K. Chester, J Hammersley, T.J. Peters; A Method for the Preparation of RNA from Human Colonic Mucosa Obtained by Colonoscopic Biopsy. Clin Sci (Lond) 1 January 1989; 76 (s20): 27P. doi: https://doi.org/10.1042/cs076027P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1989 The Biochemical Society and the Medical Research Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Prioritization of Retinal Disease Genes: An Integrative Approach (2013)

The discovery of novel disease-associated variations in genes is often a daunting task in highly heterogeneous disease classes. We seek a generalizable algorithm that integrates multiple publicly available genomic data sources in a machine-learning model for the prioritization of candidates identified in patients with retinal disease. To approach this problem, we generate a set of feature vectors from publicly available microarray, RNA-seq, and ChIP-seq datasets of biological relevance to retinal disease, to observe patterns in gene expression specificity among tissues of the body and the eye, in addition to photoreceptor-specific signals by the CRX transcription factor. Using these features, we describe a novel algorithm, positive and unlabeled learning for prioritization (PULP). This article compares several popular supervised learning techniques as the regression function for PULP. The results demonstrate a highly significant enrichment for previously characterized disease genes using a logistic regression method. Finally, a comparison of PULP with the popular gene prioritization tool ENDEAVOUR shows superior prioritization of retinal disease genes from previous studies. The java source code, compiled binary, assembled feature vectors, and instructions are available online at https://github.com/ahwagner/PULP.
Using policies for effective network management (1999)

The goal of policy-based management is to reduce the complex administration of networks. Copyright © 1999 John Wiley & Sons, Ltd.
The shape of epitaxially grown silicon nanowires and the influence of line tension (2005)

Silicon nanowires grown epitaxially via the vapor-liquid-solid mechan- ism show a larger diameter at the base of the nanowire, which cannot be explained by an overgrowth of the nanowire alone. By considering the equilibrium condition for the contact angle of the droplet, the Neumann quadrilateral relation, a quasi-static model of epitaxial nanowire growth is derived. It is found that a change of the contact angle of the droplet is responsible for the larger diameter of the nanowire base, so that the expansion has to be considered a fundamental aspect of epitaxial vapor-liquid- solid growth. By comparison of experimental results with theoretical calculations, an estimate for the line tension is obtained. In addition, the growth model predicts the existence of two different growth modes. Only within a certain range of line-tension values is the mode corresponding to ordinary nanowire growth realized, whereas nanowire growth stops at a relatively small height if the line tension exceeds an upper boundary. An approximate analytic expression for the upper boundary as a function of the surface tensions is given.