gebhart/patrepeval huggingface dataset:
Thermodynamic Dissociation Constants of Methylaminediacetic Acid and Dimethylethylenediaminediacetic Acid (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic Dissociation Constants of Methylaminediacetic Acid and Dimethylethylenediaminediacetic AcidNelson E. Ockerbloom and Arthur E. MartellCite this: J. Am. Chem. Soc. 1956, 78, 2, 267–270Publication Date (Print):January 1, 1956Publication History Published online1 May 2002Published inissue 1 January 1956https://pubs.acs.org/doi/10.1021/ja01583a004https://doi.org/10.1021/ja01583a004research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 10030: A Novel Multi-Target Drug Prevents Cancer Therapy-Induced Hypertension and Renal Damage (2021)

Introduction: Cardiovascular and kidney damage is associated with cancer therapeutics and has resulted in the clinical specialties of cardio-oncology and nephro-oncolgy. Hypothesis: Investigate a multi-target soluble epoxide hydrolase (sEH) and cyclooxygenase-2 (COX-2) inhibitor, PTUPB, on cardiovascular and kidney damage that occurs during cancer therapy with sorafenib. Method: Rats were given were administered sorafenib and administered high salt diet for 8 weeks. The study included three experimental groups (n=4-8/group); (1) control group, (2) vehicle group treated with sorafenib (20mg/kg/d), and (3) PTUPB-treated group consisting of rats which were initially treated with sorafenib for 4 weeks and subsequently co-administered PTUPB (10mg/kg/d) from weeks 4 to 8. Blood pressure was measured, and urine collected every two weeks. Plasma and kidney tissue were collected at the end of the treatment period. Additional experiments were conducted in isolated glomeruli and mesangial cell cultures. Results: After 4 weeks, sorafenib-treated rats developed hypertension (177±9 mmHg) and sorafenib resulted in a further elevation in blood pressure at week 8 (205±10 mmHg). PTUPB treatment attenuated the sorafenib-induced blood pressure elevation. After 4 weeks, sorafenib rats developed pronounced proteinuria (9.0±2 Pr/Cr), which intensified significantly (32.0±4 Pr/Cr) by the end of week 8. PTUPB mitigated sorafenib-induced proteinuria and PTUPB reduced proteinuria by 75%. Kidney histopathology revealed glomerular injury, and glomerular nephrin loss in sorafenib rats. PTUPB treatment reduced glomerular injury by 30 to 70% as well as restored glomerular nephrin expression levels. Consistent with renoprotective action, PTUPB reduced sorafenib-induced renal oxidative stress as indicated by 26% lower MDA content. In isolated glomeruli, PTUPB treatment decreased angiotensin II induced glomerular permeability. Sorafenib induced glomerular mesangial cell death was also prevented by PTUPB treatment. Conclusion: Our data demonstrate that PTUPB decreased hypertension and kidney injury associated with the cancer therapeutic sorafenib.
Intensely Luminescent Homoleptic Alkynyl Decanuclear Gold(I) Clusters and Their Cationic Octanuclear Phosphine Derivatives (2012)

Treatment of Au(SC(4)H(8))Cl with a stoichiometric amount of hydroxyaliphatic alkyne in the presence of NEt(3) results in high-yield self-assembly of homoleptic clusters (AuC(2)R)(10) (R = 9-fluorenol (1), diphenylmethanol (2), 2,6-dimethyl-4-heptanol (3), 3-methyl-2-butanol (4), 4-methyl-2-pentanol (4), 1-cyclohexanol (6), 2-borneol (7)). The molecular compounds contain an unprecedented catenane metal core with two interlocked 5-membered rings. Reactions of the decanuclear clusters 1-7 with gold-diphosphine complex [Au(2)(1,4-PPh(2)-C(6)H(4)-PPh(2))(2)](2+) lead to octanuclear cationic derivatives [Au(8)(C(2)R)(6)(PPh(2)-C(6)H(4)-PPh(2))(2)](2+) (8-14), which consist of planar tetranuclear units {Au(4)(C(2)R)(4)} coupled with two fragments [AuPPh(2)-C(6)H(4)-PPh(2)(AuC(2)R)](+). The titled complexes were characterized by NMR and ESI-MS spectroscopy, and the structures of 1, 13, and 14 were determined by single-crystal X-ray diffraction analysis. The luminescence behavior of both Au(I)(10) and Au(I)(8) families has been studied, revealing efficient room-temperature phosphorescence in solution and in the solid state, with the maximum quantum yield approaching 100% (2 in solution). DFT computational studies showed that in both Au(I)(10) and Au(I)(8) clusters metal-centered Au → Au charge transfer transitions mixed with some π-alkynyl MLCT character play a dominant role in the observed phosphorescence.
Appropriation et identification des territoires du vin : la lutte entre grands et petits propriétaires du «Corton » (2005)

A partir d’une analyse de cas, les conflits autour de la délimitation de l’appellation du vin Corton en Bourgogne dans l’entre-deux-guerres, le texte distingue deux modes de construction du territoire : l’identification, processus de désignation par l’Etat et l’appropriation, processus de revendication par les intéressés eux-mêmes. Face à l’impossible identification légitime des territoires viticoles par l’Etat, la loi de 1919 sur les appellations d’origine impose le recours à la voie judiciaire pour régler les différends. Les acteurs en conflit s’affrontent alors sur des appropriations et définitions divergentes du territoire. Chacun revendique des registres de justification différents pour tenter d’imposer son territoire. Le territoire n’est nullement un héritage naturel, mais le fruit d’un affrontement social. Si les grands propriétaires jouent d’arguments économiques et historiques pour fonder leur revendication à une zone d’appellation restrictive, les petits propriétaires, nouveaux entrants de l’appellation et de l’économie viticole de luxe, avancent eux des arguments politiques, républicains, pour séduire les tribunaux de la IIIe République. La définition du territoire et les règles du marché dépendent d’un jeu qui dépasse largement la lutte strictement économique variant selon les contextes politiques et les rapports de forces sociaux.
Breaking out of the Cloud (2017)

Many emerging IoT approaches depend on cloud services to facilitate interoperation of devices and services within them, even when all the communicating entities reside in the same local environment, as in many "smart home" applications. While such designs offer a straightforward way to implement IoT applications using today's TCP/IP protocol stack, they also introduce dependencies on external connectivity and services that are unnecessary and often brittle. This paper uses the design of an IoT-enabled home entertainment application, dubbed Flow, to demonstrate how the Named Data Networking (NDN) architecture enables cloud-independent IoT applications. NDN enables local trust management and rendezvous service, which play a foundational role in realizing other IoT services. By employing application-defined naming rather than host-based addressing at the network layer, and securing data directly, NDN enables straightforward and robust implementation of these two core functions for IoT networks without cloud connectivity. At the same time, NDN-based IoT designs can employ cloud services to complement local system capabilities. After describing the design and implementation of Flow, together with a discussion on preliminary generalization of the design, as an evaluation the paper conducts a brief thought exercise of how Flow could be realized using two popular IoT frameworks, Amazon's AWS IoT service and the Apple HomeKit framework, and compares that with the real implementation over NDN.
Robust respiration detection from remote photoplethysmography (2016)

Continuous monitoring of respiration is essential for early detection of critical illness. Current methods require sensors attached to the body and/or are not robust to subject motion. Alternative camera-based solutions have been presented using motion vectors and remote photoplethysmography. In this work, we present a non-contact camera-based method to detect respiration, which can operate in both visible and dark lighting conditions by detecting the respiratory-induced colour differences of the skin. We make use of the close similarity between skin colour variations caused by the beating of the heart and those caused by respiration, leading to a much improved signal quality compared to single-channel approaches. Essentially, we propose to find the linear combination of colour channels which suppresses the distortions best in a frequency band including pulse rate, and subsequently we use this same linear combination to extract the respiratory signal in a lower frequency band. Evaluation results obtained from recordings on healthy subjects which perform challenging scenarios, including motion, show that respiration can be accurately detected over the entire range of respiratory frequencies, with a correlation coefficient of 0.96 in visible light and 0.98 in infrared, compared to 0.86 with the best-performing non-contact benchmark algorithm. Furthermore, evaluation on a set of videos recorded in a Neonatal Intensive Care Unit (NICU) shows that this technique looks promising as a future alternative to current contact-sensors showing a correlation coefficient of 0.87.
Dmt and opioid peptides: A potent alliance (2003)

The introduction of the Dmt (2',6'-dimethyl-L-tyrosine)-Tic pharmacophore into the design of opioid ligands produced an extraordinary family of potent delta-opioid receptor antagonists and heralded a new phase in opioid research. First reviewed extensively in 1998, the incorporation of Dmt into a diverse group of opioid molecules stimulated the opioid field leading to the development of unique analogues with remarkable properties. This overview will document the crucial role played by this residue in the proliferation of opioid peptides with high receptor affinity (K(i) equal to or less than 1 nM) and potent bioactivity. The discussion will include the metamorphosis between delta-opioid receptor antagonists to delta-agonists based solely on subtle structural changes at the C-terminal region of the Dmt-Tic pharmacophore as well as their behavior in vivo. Dmt may be considered promiscuous due to the acquisition of potent mu-agonism by dermorphin and endomorphin derivatives as well as by a unique class of opioidmimetics containing two Dmt residues separated by alkyl or pyrazinone linkers. Structural studies on the Dmt-Tic compounds were enhanced tremendously by x-ray diffraction data for three potent and biologically diverse Dmt-Tic opioidmimetics that led to the development of pharmacophores for both delta-opioid receptor agonists and antagonists. Molecular modeling studies of other unique Dmt opioid analogues illuminated structural differences between delta- and mu-receptor ligand interactions. The future of these compounds as therapeutic applications for various medical syndromes including the control of cancer-associated pain is only a matter of time and perseverance.
Exchange coupled CoPt/FePtC media for heat assisted magnetic recording (2018)

L10 FePtC granular media are being studied as potential future magnetic recording media and are set to be used in conjunction with heat assisted magnetic recording (HAMR) to enable recording at write fields within the range of current day recording heads. Media structures based on a FePtC storage layer and a capping layer can alleviate the switching field distribution (SFD) requirements of HAMR and reduce the noise originating from the writing process. However, the current designs suffer from SFD issues due to high temperature writing. To overcome this problem, we study a CoPt/FePtC exchange coupled composite structure, where FePtC serves as the storage layer and CoPt (with higher Curie temperature, Tc) as the capping layer. CoPt remains ferromagnetic at near Tc of FePtC. Consequently, the counter exchange energy from CoPt would reduce the noise resulting from the adjacent grain interactions during the writing process. CoPt/FePtC bilayer samples with different thicknesses of CoPt were investigated. Our studies found that CoPt forms a continuous layer at a thickness of 6 nm and leads to considerable reduction in the saturation field and its distribution.
Application of Sludge Activated Carbon in Wastewater Treatment (2011)

Large numbers of municipal sludge were produced during the disposal of city water.With municipal sludge on the preparation of activated carbon was a new method to disposal it.The principle of activated carbon in wastewater treatment and its application in variou wastewater were reviewed.And it was think the activated carbon would provide a new way for the sustainable development of urban wastewater treatment plant.
Gold Catalysis:  On the Phenol Synthesis (2001)

[reaction--see text] For the gold-catalyzed phenol synthesis an intramolecular migration of the oxygen atom was proven. Several other late transition metals with d(8) configuration allow this conversion, providing evidence for Au(III) being a catalytically active species. On the other hand gold was still the most active catalyst and gives the cleanest conversion. With additional alkynyl substituents another ring could be closed to provide doubly annellated arenes.
Electrical and Optical Properties of Ferroelectric Bi4Ti3O12 Single Crystals (1968)

The symmetry of ferroelectric Bi4Ti3O12 is shown to be monoclinic point group m. The spontaneous polarization PS is approx 50 μC/cm2 at 25°C and lies in the monoclinic a-c plane at an angle of less than 5 deg from the plane of the crystal sheets. A complete determination of the optical indicatrix as a function of temperature is given. Switching for fields along the c axis occurs by a unique ``rocking'' of the large PS vector and leads to interesting electrical-optical behavior. The domain structure is quite complex, and observed wall orientations are compared with those predicted theoretically.
An Optimized Hybrid Pseudospectral/finite-difference Modeling of TTI Pure P-wave Equation and Reverse Time Migration (2017)

Summary In recent years, many scholars have proposed some new seismic numerical simulation methods in tilted transversely isotropic (TTI) media. The purpose of these schemes is to remove the shear-wave artefacts and to make the wavefield stable in media with highly varying dip and azimuth angles. Obviously, some methods will lead to a low speed of calculation. We consider that hybrid pseudo-spectrum and finite difference TTI pure P-wave equation can remove the shear-wave components well. So, we add the optimized operator to improve the fitting degree of the wave number terms, meanwhile make the finite difference terms to eight-order accuracy. This scheme improves the stability of the pure P-wave equation. We convert the equation into a format with one forward FFT and two inverse FFTs. Fewer wavenumber terms and more finite-difference terms can reduce the computational complexity of each time step. In the 2D fault model, numerical simulation is carried out, and reverse time migration imaging is performed with the excitation amplitude imaging conditions. We can conclude that this optimized hybrid pseudospectral/finite-difference scheme can provide stable and accurate seismic data in the complex TTI model.
Optical Spin-to-Orbital Angular Momentum Conversion in Inhomogeneous Anisotropic Media (2006)

We demonstrate experimentally an optical process in which the spin angular momentum carried by a circularly polarized light beam is converted into orbital angular momentum, leading to the generation of helical modes with a wave-front helicity controlled by the input polarization. This phenomenon requires the interaction of light with matter that is both optically inhomogeneous and anisotropic. The underlying physics is also associated with the so-called Pancharatnam-Berry geometrical phases involved in any inhomogeneous transformation of the optical polarization.
Photodamage: All Signs Lead to Actinic Keratosis and Early Squamous Cell Carcinoma (2014)

Ultraviolet (UV) radiation is likely to drive the initiation and progression of skin cancer from actinic keratosis to squamous cell carcinoma. Signs of photodamage occur at multiple steps. UV radiation damages many cellular constituents, including lipids, proteins and DNA, all of which are likely to contribute to UV-induced skin cancer. Two biological events culminating from photodamage are mutations in the genes critical to the control of cell division, differentiation and invasion and immunosuppression. DNA photodamage, if unrepaired prior to cell division, can result in the incorporation of an incorrect nucleotide into newly synthesised DNA. Mutations in critical genes contribute to carcinogenesis. Photodamage to proteins such as those involved in DNA repair or proteins or lipids involved in cellular signalling can interfere with this repair process and contribute to mutagenesis. Mutations in key genes, including TP53, BRM, PTCH1, and HRAS, contribute to skin carcinogenesis. UV also damages immunity. Photodamage to DNA and signalling lipids as well as other molecular changes are detrimental to the key cells that regulate immunity. Photodamaged dendritic cells and altered responses by mast cells lead to the activation of T and B regulatory cells that suppress immunity to the protein products of UV-mutated genes. This stops the immune response from its protective function of destroying mutated cells, enabling the transformed cells to progress to skin cancer. UV appears to play a pivotal role at each of these steps, and therefore, signs of photodamage point to the development of skin cancer.
Compromising Tor Anonymity Exploiting P2P Information Leakage (2010)

Privacy of users in P2P networks goes far beyond their current usage and is a fundamental requirement to the adoption of P2P protocols for legal usage. In a climate of cold war between these users and anti-piracy groups, more and more users are moving to anonymizing networks in an attempt to hide their identity. However, when not designed to protect users information, a P2P protocol would leak information that may compromise the identity of its users. In this paper, we first present three attacks targeting BitTorrent users on top of Tor that reveal their real IP addresses. In a second step, we analyze the Tor usage by BitTorrent users and compare it to its usage outside of Tor. Finally, we depict the risks induced by this de-anonymization and show that users' privacy violation goes beyond BitTorrent traffic and contaminates other protocols such as HTTP.
A Mouse Histone H4 Gene Carried by an SV40 Vector is Accurately Expressed in Infected Monkey Cells (1984)

We present evidence that a cloned mouse histone H4 gene contains all the information required for the generation of functional H4 mRNA. The cloned mouse gene, flanked by spacer sequences extending 228 bp at the 5' end and 1100 bp at the 3' end, was introduced into the late region of the SV40 genome and the recombinant virus was used to infect cultured monkey kidney cells. RNA mapping studies demonstrated that the H4 transcripts from the infected cells could be initiated at either the mouse or viral promoter and that the majority of the RNA had the same 3' end as authentic mouse H4 RNA. The mouse RNA was incorporated into polysomes and there was a specific increase in H4 protein synthesis in cells infected with the recombinant virus. The distribution of the H4 transcripts between the polysomal and postpolysomal fractions suggests that RNA initiated at the mouse promoter is more efficiently bound to polysomes than is the hybrid RNA initiated at the SV40 promoter.
Perfluorocarbons and Semifluorinated Alkanes (2000)

The introduction of perfluorocarbons (PFCs) and, more recently, semifluorinated alkanes (SFAs) has greatly facilitated vitreoretinal surgery. A distinction is made between the use of these substances as intraoperative tools and internal tamponade agents. This article reviews the physical and chemical properties of PFCs and SFAs and discusses the indications, results, and complications. The effectiveness of these substances as internal tamponade agents is discussed with reference to the specific gravity, contact angle, viscosity and ability to fill model eye chambers and the vitreous cavity. The evidence for the toxicity in animal and human is examined.
Atomic‐scale investigation of the localized corrosion of passivated nickel surfaces (2002)

Abstract In situ scanning tunnelling microscopy measurements of the localized corrosion of Ni(111) surfaces passivated in a chloride‐free sulphuric acid solution and subsequently exposed to chloride (0.05 M ) are reported. The results support the deterministic role of the structure of the passivated surface on the dissolution in the passive state, independent of the addition of chloride in the electrolyte. The atomic lattice of the passive film formed in the absence of chloride is unmodified after the addition of chloride. At the investigated potential of +0.85 V SHE (0.05 V below the stable pitting potential), the dissolution proceeds by a two‐dimensional step flow process that is dependent on the step orientation, the steps oriented along the closed‐packed directions dissolving much less rapidly than the steps oriented along no well‐defined directions of the oxide lattice. The dissolution rate of the oxide lattice is ∼6 NiO ‘molecules’ s −1 , independent of the presence of chloride. The comparison with the rate of dissolution that can be estimated from the measured electrochemical current density in the passive state suggests that the dissolution of the oxide lattice of the passive film is not the major anodic reaction in the passive state. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Prehospital Prasugrel Versus Ticagrelor in Real-World Patients With ST-Elevation Myocardial Infarction Referred for Primary PCI: Procedural and 30-Day Outcomes. (2018)

Prehospital administration of both prasugrel and ticagrelor in STEMI patients is safe, without differences in preprocedural and postprocedural reperfusion and short-term clinical outcomes.
East London line enabling works contracts (2012)

Construction of phase 1 of the new London Overground East London line was completed in 2010. Two enabling works contracts preceded the main contract for the construction of the railway. This paper gives the historical background of the old railway structures in east London that have been brought back into use for the new railway, and describes the many different forms of refurbishment or replacement that had to be undertaken to bring the old infrastructure up to modern standards.
Fast Facts: Acne (2016)

Acne is one of the ten most common diseases worldwide and is the inflammatory skin disease seen most frequently by community physicians and dermatologists. Over the last decade, knowledge of acne pathophysiology and etiologic factors has expanded, resulting in the development of novel treatments that target clinical lesions and improve patient outc