gebhart/patrepeval huggingface dataset:
Asher Mandelbaum (1934–2020) (2020)

ADVERTISEMENT RETURN TO ISSUEPREVObituaryNEXTAsher Mandelbaum (1934–2020)Adrian WeiszAdrian WeiszCenter for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, United StatesMore by Adrian Weiszhttp://orcid.org/0000-0003-1835-3499 and Sanford P. MarkeySanford P. MarkeyChief, retired, Laboratory of Neurotoxicology, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, United StatesMore by Sanford P. MarkeyCite this: J. Am. Soc. Mass Spectrom. 2021, 32, 1, 398–400Publication Date (Web):December 24, 2020Publication History Received9 December 2020Accepted21 December 2020Revised17 December 2020Published online24 December 2020Published inissue 6 January 2021https://pubs.acs.org/doi/10.1021/jasms.0c00454https://doi.org/10.1021/jasms.0c00454obituaryACS PublicationsCopyright © 2020 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views973Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Fragmentation,Ions,Mass spectrometry,Molecular structure,Students Get e-Alerts
[Animal experimental studies on the pharmacokinetics of "essential" phospholipids (EPL)]. (1976)

The pharmacokinetics of orally applied "essential" phospholipids (EPL) (i.e. polyenyl phosphatidyl choline) was investigated in conscious and in anesthetized rats with the aid of radioactively labelled dilinolyl phosphatidylcholines (3H and 14C.). Absorption, distribution and metabolism of EPL were studied using autoradiography and by measuring the distribution of the abosrbed radioactivity in lymph, blood and internal organs, and by determining excretion and expiration.
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis (2017)

TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-VCP complex and reduces FAF1 at the plasma membrane. The latter results in an increase in TβRII at the cell surface that promotes both TGF-β-induced SMAD and non-SMAD signalling. We uncover a metastasis suppressing role for FAF1 through analyses of FAF1-knockout animals, various in vitro and in vivo models of epithelial-to-mesenchymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progression and clinical breast cancer samples. These findings describe a previously uncharacterized mechanism by which TβRII is tightly controlled. Together, we reveal how SMAD and AKT pathways interact to confer pro-oncogenic responses to TGF-β.
Canopy tree competition and species coexistence in anAbies veitchiiandA. mariesiimixed subalpine forest, central Japan (1994)

The mode of competition in a crowded subalpine mixed forest of Abies veitchii Lindley and A. mariesii Masters, central Japan, was investigated by using spatial and non-spatial competition models for stem diameter (d.b.h.) and tree height growth. (1) Size distribution of tree height became bimodal as the stand developed, where the relative abundance (in terms of tree number and basal area) of A. mariesii increased in the lower vertical layer but both species kept almost constant relative abundances in the upper layer; (2) there was little difference in the growth patterns (size-dependent mean absolute growth rate and variance in absolute growth rate) of d.b.h. and tree height for canopy trees ≤ 1.3 m in height between A. veitchii and A. mariesii; (3) for small saplings ≤ 1.3 m in height, the growth pattern was somewhat different between the two Abies species: the variance and/or the mean of relative height growth rates of A. mariesii saplings were significantly greater than those of A. veitchii saplings under relatively dark conditions (5-20 % relative light intensity); (4) mortality rate of small trees of A. mariesii was lower than that of A. veitchii; (5) A. veitchii underwent symmetric competition, whilst A. mariesii gave little indication of competition in individual growth. It is concluded that the vertical community structure of this mixed forest was induced by difference in the mortality rate of small trees between the two species but not by the growth patterns of canopy trees or competitive interactions between canopy trees. The coexistence of A. veitchii and A. mariesii was governed by the mortality and recruitment rates of small saplings but not by the growth patterns of canopy trees or competitive interactions between canopy trees.
Photometric Scalp Morphology Estimation through Hair for Optical Functional Neuroimaging (2022)

Optical functional neuroimaging relies on accurate anatomical models of head size and shape for optimal data registration and image reconstruction. Herein, we establish and validate photometric methods for scalp morphology estimation through hair.
Novel, synergistic composites of polypropylene and rice husk ash: Sustainable resource hybrids prepared by solid‐state shear pulverization (2013)

Rice husk ash (RHA) is an agrowaste byproduct resulting from the incineration of rice husks for power production; white RHA is ∼90 wt% or more silica, which makes it a potentially sustainable and inexpensive substitute for commercial (less “green”) silica filler. Past research on polypropylene (PP)‐RHA hybrids made by melt processing has yielded modest increments in Young's modulus, reduced yield strength, and drastic reductions in elongation at break relative to neat PP. Using the industrially scalable solid‐state shear pulverization (SSSP) process, PP‐RHA hybrids are made with 4–38 wt% RHA. As determined by microscopy and other methods, composites made by SSSP have much better RHA dispersion than composites reported in the literature made by twin‐screw extrusion. The superior dispersion leads to major enhancements in tensile modulus (up to 100% increases relative to neat PP) while maintaining the yield strength of neat PP and remarkably high values of elongation at break (e.g., 520% at 19 wt% RHA), far higher than composites made by melt processing. The properties of hybrids made by SSSP are competitive with and in some cases superior to those of PP hybrids made with commercial silica. The PP‐RHA hybrids also exhibit major increases in hardness, approaching that of polycarbonate in the case of a 38 wt% RHA hybrid. The 38 wt% RHA hybrid exhibits solid‐like rheology at low frequency. Nevertheless, all PP‐RHA hybrids made by SSSP exhibit viscosities at moderate to high shear rates that are little changed from that of neat PP. POLYM. COMPOS., 34:1211–1221, 2013. © 2013 Society of Plastics Engineers
Role of endothelin during experimental Trypanosoma cruzi infection in rats (2002)

Chagas' disease is caused by the intracellular protozoan Trypanosoma cruzi. Here we have investigated the role of endothelin-1 in T. cruzi acute infection in rats, using the orally active ET(A) receptor antagonist BSF-461314. Treatment with BSF-461314 markedly increased parasitaemia, but animals managed to control the infection by day 15. Histopathological analysis of heart tissue at the end of the acute phase showed greater numbers of parasite nests in BSF-461314-treated animals. The perfusion of isolated rat hearts from infected animals with bradykinin failed to induce an increase, and actually reduced, coronary blood flow. Pretreatment with BSF-461314 prevented changes in coronary flow induced by T. cruzi infection. Together these results demonstrate that endothelin-1, through ET(A) receptor activation, contributes to the protective immune response against acute T. cruzi infection. Moreover, these data suggest that endothelin-1 is a mediator of impaired endothelium-dependent vasomotion in the coronary microcirculation associated with acute T. cruzi infection.
Resource Management Services (2018)

This chapter describes the DREAMS Resource Management Services, which are composed of the Global Resource Manager, Local Resource Managers (LRM), Local Resource Schedulers (LRS) and Resource Monitors (MON) services. It provides an overview of the Resource Management (RM) services by giving a short definition of each RM component. The chapter elaborates on the MON, LRS, LRM and GRM respectively by describing the general approach and exhibiting an implementation of each. DREAMS provides a set of services for system-wide adaptability of mixed-criticality applications consuming several resources via global integrated RM. The implementation of the MON for deadline overrun is hardware dependent and the timing is computed with local core registers. The execution of the MON for Quality of Service takes the advantage of deadline overrun monitoring actions to capture the behavior of critical applications. The operation of the LRM is constrained by a complete symmetric local reconfiguration graph.
Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion. (1997)

Melatonin inhibits the production of hydroxyl radicals in rat brain during ischemia and reperfusion.
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1 (2022)

It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only marginally affects expression of most genes despite substantially perturbing three-dimensional (3D) genome folding at the level of domains and structural loops. To address this conundrum, we used high-resolution Micro-C and nascent transcript profiling in mouse embryonic stem cells. We find that enhancer-promoter (E-P) interactions are largely insensitive to acute (3-h) depletion of CTCF, cohesin or WAPL. YY1 has been proposed as a structural regulator of E-P loops, but acute YY1 depletion also had minimal effects on E-P loops, transcription and 3D genome folding. Strikingly, live-cell, single-molecule imaging revealed that cohesin depletion reduced transcription factor (TF) binding to chromatin. Thus, although CTCF, cohesin, WAPL or YY1 is not required for the short-term maintenance of most E-P interactions and gene expression, our results suggest that cohesin may facilitate TFs to search for and bind their targets more efficiently.
The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia (2018)

Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the attenuation of cell damage pathways, including the apoptotic cell death. In this context, p53 is a stress sensor that accumulates during brain ischemia leading to neuronal death. The murine double minute 2 gene (MDM2), a p53-specific E3 ubiquitin ligase, is the main cellular antagonist of p53, mediating its degradation by the proteasome. Here, we study the role of MDM2-p53 pathway on PC-induced neuroprotection both in cultured neurons (in vitro) and rat brain (in vivo). Our results show that PC increased neuronal MDM2 protein levels, which prevented ischemia-induced p53 stabilization and neuronal death. Indeed, PC attenuated ischemia-induced activation of the p53/PUMA/caspase-3 signaling pathway. Pharmacological inhibition of MDM2-p53 interaction in neurons abrogated PC-induced neuroprotection against ischemia. Finally, the relevance of the MDM2-p53 pathway was confirmed in rat brain using a PC model in vivo. These findings demonstrate the key role of the MDM2-p53 pathway in PC-induced neuroprotection against a subsequent ischemic insult and poses MDM2 as an essential target in ischemic tolerance.
Brucella abortus Cyclic β-1,2-Glucan Mutants Have Reduced Virulence in Mice and Are Defective in Intracellular Replication in HeLa Cells (2001)

Null cyclic beta-1,2-glucan synthetase mutants (cgs mutants) were obtained from Brucella abortus virulent strain 2308 and from B. abortus attenuated vaccinal strain S19. Both mutants show greater sensitivity to surfactants like deoxycholic acid, sodium dodecyl sulfate, and Zwittergent than the parental strains, suggesting cell surface alterations. Although not to the same extent, both mutants display reduced virulence in mice and defective intracellular multiplication in HeLa cells. The B. abortus S19 cgs mutant was completely cleared from the spleens of mice after 4 weeks, while the 2308 mutant showed a 1.5-log reduction of the number of brucellae isolated from the spleens after 12 weeks. These results suggest that cyclic beta-1,2-glucan plays an important role in the residual virulence of the attenuated B. abortus S19 strain. Although the cgs mutant was cleared from the spleens earlier than the wild-type parental strain (B. abortus S19) and produced less inflammatory response, its ability to confer protection against the virulent strain B. abortus 2308 was fully retained. Equivalent levels of induction of spleen gamma interferon mRNA and anti-lipopolysaccharide (LPS) of immunoglobulin G2a (IgG2a) subtype antibodies were observed in mice injected with B. abortus S19 or the cgs mutant. However, the titer of anti-LPS antibodies of the IgG1 subtype induced by the cgs mutant was lower than that observed with the parental S19 strain, thus suggesting that the cgs mutant induces a relatively exclusive Th1 response.
A novel approach for evaluating the performance of real time quantitative loop-mediated isothermal amplification-based methods (2014)

Molecular diagnostic measurements are currently underpinned by the polymerase chain reaction (PCR). There are also a number of alternative nucleic acid amplification technologies, which unlike PCR, work at a single temperature. These 'isothermal' methods, reportedly offer potential advantages over PCR such as simplicity, speed and resistance to inhibitors and could also be used for quantitative molecular analysis. However there are currently limited mechanisms to evaluate their quantitative performance, which would assist assay development and study comparisons. This study uses a sexually transmitted infection diagnostic model in combination with an adapted metric termed isothermal doubling time (IDT), akin to PCR efficiency, to compare quantitative PCR and quantitative loop-mediated isothermal amplification (qLAMP) assays, and to quantify the impact of matrix interference. The performance metric described here facilitates the comparison of qLAMP assays that could assist assay development and validation activities.
Jaboticaba peel extract as an antimicrobial agent: screening and stability analysis (2021)

Purpose This study aimed to evaluate the antimicrobial activity of the aqueous extract from jaboticaba skin against important foodborne bacteria and fungi and its stability. Design/methodology/approach Jaboticaba skin aqueous extract (at ratio of 10 g L-1) was tested against Listeria monocytogenes , Staphylococcus aureus , Bacillus cereus and Escherichia coli . Stability of the anti-staphylococcal activity, total phenolics, monomeric anthocyanins, tannins, phenolic acid content were measured and statistically correlated. Findings The residue extract inhibited L.monocytogenes, S.aureus, B.cereus and E.coli growth but was not effective against fungi and was stable to the thermal treatments, remaining with its inhibitory activity against S.aureus. When stored for 14 days at 25 °C with an incidence of light, there was a reduction in the antibacterial activity and in the phenolic compounds. The change in pH slightly changed polyphenolic content profile, and the exposure to papain and bromelain did not affect the antimicrobial activity. Results showed strong correlation between anti-staphylococcal activity, the presence of polyphenols and anthocyanins, meanwhile moderate correlation with phenolic acids content in the extract. Originality/value Biopreservatives are a great trend in food microbiology. The present work shows deeper information about the utilization of jaboticaba skin as antimicrobial agent and its stability, which is not found in the current literature.
IT-30 * ReACT: A PHASE II STUDY OF RINDOPEPIMUT VACCINE (CDX-110) PLUS BEVACIZUMAB IN RELAPSED GLIOBLASTOMA (2014)

BACKGROUND: EGFRvIII, a constitutively active tumorigenic EGFR deletion mutation, is linked to poor long-term survival. The investigational vaccine rindopepimut consists of the unique EGFRvIII peptide sequence conjugated to keyhole limpet hemocyanin (KLH), delivered intradermally with GM-CSF. Three phase II studies of rindopepimut in newly diagnosed, resected, EGFRvIII+ glioblastoma have shown encouraging PFS and OS. Bevacizumab (BV), an agent with activity in glioblastoma, may augment EGFRvIII-specific immune response and antitumor activity through inhibition of VEGF and its immunosuppressive properties. METHODS: “ReACT” is a Phase II study of rindopepimut plus BV in patients with 1st or 2nd relapse of EGFRvIII+ glioblastoma. BV-naïve pts (Group 1; n = 70) are randomized 1:1 to BV plus double-blinded injection of either rindopepimut or control (KLH). BV-refractory patients (progression within 2 months of BV; Group 2/2C, n = 98) receive BV plus open-label rindopepimut. RESULTS: 234/700 (33%) screened patients are EGFRvIII+. 115 patients (Group 1 = 72, Group 2/2C = 43) are enrolled. Primary toxicity is Grade 1-2 injection site reaction. In group 1, for rindopepimut + BV vs. KLH + BV, objective response rate (ORR; investigator-assessed, RANO criteria) is 23% (6/26) vs 12% (3/25) [35% vs. 20% including responses observed at a single time point (“unconfirmed”)]. In Group 2/2C (evaluable n = 30), one unconfirmed PR and one sustained PR (patient continues treatment at 15 months) occurred. Two additional patients had pre-study progression >2 months after BV; one maintained a CR for 11.1 months (peak anti-EGFRvIII titer = 1:3,276,800), while the second experienced an unconfirmed CR. Median peak rindopepimut-induced anti-EGFRvIII humoral response is 1:25,600 [range <1:100-1:6,553,600]). Rapid titer generation was associated with prolonged OS (Group 2: p = 0.01). CONCLUSIONS: Rindopepimut + BV has induced potent EGFRvIII-specific immune response and tumor regression in immunosuppressed recurrent glioblastoma patients naive or refractory to BV. Full response, PFS and OS data are expected to further define the potential clinical benefit of the combination in relapsed glioblastoma.
Process for the manufacturing of cellulose pulp : Förfarande och kokerisystem för framställning av cellulosamassa (2002)

The invention concerns a method for the production of cellulose pulp, in which wood raw material that principally comprises softwood, preferably in the form of cut wood chips, is treated in several ...
Figure S7-S8 from Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression (2023)

&lt;p&gt;Figure S7 shows the analysis of miR array between WT and A-FABP-/- macrophages. Figure S8 demonstrates that A-FABP expression in macrophages promotes E0771 tumor lung metastasis&lt;/p&gt;
Fuel Economy and Performance of Mild Hybrids with Ultracapacitors: Simulations and Vehicle Test Results (Presentation) (2009)

NREL worked with GM and demonstrated equivalent performance in the Saturn Vue Belt Alternator Starter (BAS) hybrid vehicle whether running with its stock batteries or a retrofit ultracapacitor system.
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells (2023)

Our study demonstrates the potential of first-in-class LAT1 inhibitor nanvuranlat as a concomitant drug with cytotoxic anticancer drugs, especially gemcitabine, on pancreatic and biliary tract cancers.
Current applications of lasers in heart disease (1993)

Although the laser has been in existence for abut 30 years, its application in heart disease has only been examined in the past decade. Much attention has been given its exciting potential in treating coronary artery disease. Transmitted through a catheter comprised of one or more thin optical fibers which can be threaded nonsurgically into the coronary artery, the laser can ablate atherosclerotic plaque that obstructs the artery and diminishes blood flow to the myocardium. In clinical studies, the laser can treat some obstructive lesions that are not suitable for balloon angioplasty (i.e., long and diffuse lesions, very tight stenoses, ostial lesions, calcified lesions). In patients who failed balloon angioplasty due to severe dissection or abrupt closure, the laser may seal up the dissections and restore antegrade blood flow. In addition, the laser may have other applications and treatment modalities that are still under investigation. It may ablate ectopic ventricular foci, or terminate supraventricular tachyrhythmia by destroying the heart's abnormal conduction pathways. It can cut the hypertrophied septum that is associated with left ventricular outflow tract obstruction, or create a channel in the atrial septum as a palliative procedure in newborns with transposition of the great vessels. It may provide a wider orifice for blood flow within the heart in infants with pulmonary outflow obstruction and in adults with aortic valvular stenosis. It is also capable of fusing small thin-walled blood vessels together. Further, a more intriguing possibility is its use to bore several tiny channels in the myocardium to allow oxygenated blood from within the ventricular chamber to perfuse the ischemic heart tissue.