gebhart/patrepeval huggingface dataset:
Indolent Closure Creation (1998)

A closure is a representation of a thread in memory, ready to be executed. The goal of this work is to create portable closures that can be transferred across binary incompatible architectures. Consequently, indolent closures are software-implemented, and rely on a copy mechanism which allows for potential data representation conversion on-the-fly. Indolent closure creation optimizes the current implementation of the algorithmic multithreaded language Cilk. Rather than generating parallelism eagerly by pushing closures on a ready deque whenever a parallel spawn occurs, indolent closures are created only if the ready deque is empty and a steal request occurs. Indolent closure creation is based on the release-andresume transformation, developed for the portable checkpoint compiler porch. Experimental results on various architectures show that indolent closure creation reduces the cost of a parallel spawn to be competitive with the cost of a sequential function call.
Mutual authentication in RFID (2008)

In RFID protocols, tags identify and authenticate themselves to readers. At Asiacrypt 2007, Vaudenay studied security and privacy models for these protocols. We extend this model to protocols which offer reader authentication to tags. Whenever corruption is allowed, we prove that secure protocols cannot protect privacy unless we assume tags have a temporary memory which vanishes by itself. Under this assumption, we study several protocols. We enrich a few basic protocols to get secure mutual authentication RFID protocols which achieve weak privacy based on pseudorandom functions only, narrow-destructive privacy based on random oracles, and narrow-strong and forward privacy based on public-key cryptography.
Prediction of unknown deep foundation lengths using the Hilbert Huang Transform (HHT) (2012)

Prediction of unknown deep foundation embedment depth is a great deal nowadays, especially in case of upgrading or rehabilitation of old structures. Many old bridges and marine or pier structures in the United States are established using deep foundations system of timber piles and their foundation records do not exist. Non-Destructive Testing (NDT) or Non-Destructive Evaluation (NDE) method for a great variety of materials and structures has become an integral part of many tests. However, the process of testing long piles, deeply embedded in the ground, is more complex than (NDT) of the other structural materials. This paper summarizes some of the most common non-destructive test methods for deep foundations and presents a new method called the Hilbert Huang Transform (HHT). This Hilbert Huang Transform (HHT) method is used now by a wide range in a different health monitoring of many systems. In this paper, some field tests on the timber Piles of one bridge at North Carolina was performed to verify the using the (HHT) method for predicting the embedded depth of the unknown piles. Percentage of the accuracy achieved using HHT method for pile length compared to the actual pile length data was performed. Finally, a recommendation is presented for the limitation of using this new method as a new non-destructive method for deep foundations.
Stepped electrophoresis for movement and concentration of DNA (2023)

A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is caused to move. By using a series of electrodes, when one electrode voltage or charge is made negative with respect to adjacent electrodes, the DNA is repelled away from this electrode and attached to a positive charged electrode of the series. By sequentially making the next electrode of the series negative, the DNA can be moved to and concentrated over the remaining positive electrodes.
Solvent extraction of cesium by substituted crown ethers (1996)

The extraction of alkali metal nitrates by 18-crown-6, 21-crown-7, and 24-crown-8 ethers, bearing cyclohexano, benzo-, t-alkylbenzo, and furano- substituents, in 1,2-dichloroethane has been surveyed. Introduction of a furano substituent onto the macrocyclic ring of 18-crown-6 or 21 crown-7 ethers causes a significant reduction in both extraction efficiency and selectivity. Addition of an additional benzo group to dibenzo-21 -crown-7, to give tribenzo-21 -crown-7, decreases both extraction efficiency and selectivity, whereas addition of one or two additional benzo groups to dibenzo-24-crown-8 increases the extraction efficiency and selectivity for the larger ions Rb+ and Cs{sup +} Detailed equilibrium modeling of the extraction by lipophilic 21 -crown-7 ethers indicates that the addition of t-alkyl substituents onto the benzo groups has only a minor effect on the extraction of cesium nitrate by dibenzo-21 -crown-7 ethers.
Atomic negative-ion-photodetachment cross-section and affinity measurements (1955)

The spec tral d istribu t ions of t he H -a nd 0-cross sectio ns fo r photodeta chmen t ha ve bee n meas ured. The H -meas m ements are co ns isten t wi th t he t heor y of Chandrasekhar. A c ur v~ has been fi tted to t he res ul ts for 0 -. The t hres ho ld of this cross section, t he a ffi nity of 0 -, IS found to be l. 48 0.10 electron volts . No evidence is fo und f or reso na nce a t t he t hres hold 01' for t he ex iste nce of excited 0 -ions . The apparatus is described in d etail.
Facile Syntheses of Valiolamine and Its Diastereomers from (−)-Quinic Acid.1 Nucleophilic Substitution Reactions of 5-(Hydroxymethyl)cyclohexane-1,2,3,4,5-pentol (1996)

Valiolamine (1), 1-epi-valiolamine (2), 2-epi-valiolamine (3), (1R,2R)-valiolamine (4), and 2-amino regioisomer 17 have been prepared from (−)-quinic acid (6) in 14 (8.4% overall yield), 13 (9.0%), 15 (4.3%), 17 steps (2.5%), and 12 steps (13%), respectively. Charged nucleophilic ring-openings of cyclic sulfate (1R,2S,3S,4S,5S)-4,5-di-O-acetyl-3-O-benzyl-5-(benzyloxymethyl)-1,2-O,O-sulfonylcyclohexane-1,2,3,4,5-pentol (11) occurred regioselectively at C-2, whereas the corresponding ring-openings of its (1S,2R)-diastereomer 34 proceeded preponderantly at C-1. (1R,2S,3R,4S,5S)-2,4,5-Tri-O-acetyl-3-O-benzyl-5-((benzyloxy)methyl)-1-O-(trifluoromethanesulfonyl)cyclohexane-1,2,3,4,5-pentol (24) underwent novel internal displacement spontaneously to form (1S,2S,3R,4S,5S)-1,2,4-tri-O-acetyl-3-O-benzyl-5-((benzyloxy)methyl)cyclohexane-1,2,3,4,5-pentol (25), whereas its 2-epimer was inert under the same conditions. Ruthenium-catalyzed dihydroxylation of alkene, (3R,4S,5S)-4,5-O-acetyl-3-O-benzyl-5-((benzyloxy)methyl)-1-cyclohexene-3,4,5-triol (31), gave the desired β-1,2-diol 32 in higher yield and stereoselectivity than the osmium tetraoxide protocol. The regioselectivity of charged nucleophilic ring-openings of cyclic sulfates 11, 34, and 38 is discussed.
Dynamics of initial colonization of nonconserved perennial ryegrass by anaerobic fungi in the bovine rumen (2008)

Anaerobic fungi (Neocallimastigales) are active degraders of fibrous plant material in the rumen. However, only limited information is available relating to how quickly they colonize ingested feed particles. The aim of this study was to determine the dynamics of initial colonization of forage by anaerobic fungi in the rumen and the impact of different postsampling wash procedures used to remove loosely associated microorganisms. Neocallimastigales-specific molecular techniques were optimized to ensure maximal coverage before application to assess the population size (quantitative PCR) and composition (automated ribosomal intergenic spacer analysis) of the colonizing anaerobic fungi. Colonization of perennial ryegrass (PRG) was evident within 5 min, with no consistent effect of time or wash procedure on fungal population composition. Wash procedure had no effect on population size unlike time, which had a significant effect. Colonizing fungal population size continued to increase over the incubation period after an initial lag of c. 4 min. This dynamic differs from that reported previously for rumen bacteria, where substantial colonization of PRG occurred within 5 min. The observed delay in colonization of plant material by anaerobic fungi is suggested to be primarily mediated by the time taken for fungal zoospores to locate, attach and encyst on plant material.
Thromboxane A2 Antagonist : Discovery of Seratrodast (1999)

We were interested in RCS (rabbit aorta contracting substance) and SRS-A (slow reacting substance of anaphylaxis) and their involvement in human bronchial asthma. When we started our anti-asthmatic drug research in the 1970's. We synthesized a lot of chemical compounds and eventually discovered that AA-861 inhibited the generation of SRS-A from the lung tissue of actively sensitized guinea pigs. AA-861 was found to be a potent 5-lipoxygenase inhibitor. This compound reduced experimental allergic asthma in guinea pigs, but it is easily metabolized in the body. More recently, we found a novel compound, AA-2414 (seratrodast), which is not metabolized in the body. AA-2414 proved to be not a 5-lipoxygenase inhibitor, but a thromboxane A2 (TXA2) receptor antagonist. Seratrodast is the first receptor antagonist that is being developed as an anti-asthmatic drug. Seratrodast inhibits both immediate-, late asthmatic responses in guinea pigs, and also reduces airway hyperresponsiveness in dogs. The anti-asthmatic action of seratrodast in animal models indicates that the drug should be of use in the treatment of human asthmatics. In clinical studies, seratrodast showed a marked effect to improve clinical parameters in bronchial asthma. It is also reported that seratrodast is free from harmful aftereffects. Clinical trials are under way in the US.
Overnight CSII as supplement to oral antidiabetic drugs in Type 2 diabetes (2007)

CSII with an insulin analogue overnight effectively reduced FPG without occurrence of major hypoglycaemia in type 2 diabetic patients who fail to achieve glycaemic control on oral antidiabetic treatment.
Proteolysis and Flavor Development in Cheddar Cheese Made Exclusively with Single Strain Proteinase-Positive or Proteinase-Negative Starters (1990)

Cheddar cheese made with proteinasepositive Lactococcus lactis ssp. cremoris UC 317 or its proteinase-negative variant UC 041 were monitored during ripening. Qualitatively, electrophoretograms of the cheeses were similar throughout ripening, but electrophoretograms of water-soluble N extracts from the proteinase-negative cheeses were significantly different from those of the proteinase-positive cheeses. The levels of water-soluble N in proteinase-positive and proteinase-negative cheeses of the same age were not significantly different. However, the proteinasepositive cheese had a significantly higher level of amino N throughout ripening. Proteinase-positive cheeses received slightly higher scores for flavor and body and texture than proteinase-negative cheeses of the same age. Nevertheless, the overall quality of all the cheeses was good, suggesting that starter peptidase activity may be more important than starter proteinases in flavor development in cheese during ripening.
Biodevice optimization based on piezoresistive sensor dedicated to monitoring the culture of fibroblast collagen lattices (2016)

Cell culture is an alternative method to animal dermis use in drug screening. This one became essential since Europe Commission interdicted animal testing. In this context the aim of our study is to manufacture a low cost bio-device with a high the sensitivity of detection that will permit us to understand the mechanical behavior of equivalent dermis. This biodevice is describe by the rectangular membrane integrating the grids or microcantilevers with piezoresistivity as the detection mechanism. It has been fabricated using micromachining technology. We will more detailed these optimization biodevices through the full length paper and the first characterization results will be provided.
Comparison of Temperature and Light Intensity Effects on the Photooxidation of Toluene-NOx-Air Mixture (2007)

To differentiate temperature effect from the light intensity effect on the formation of secondary products during the photooxidation of toluene-<TEX>$NO_x$</TEX>-air mixtures, steady-state air temperature was changed from <TEX>$20^{\circ}C\;to\;33^{\circ}C$</TEX> at the same light intensity of <TEX>$0.39min^{-1}$</TEX> in an indoor smog chamber. Smog chamber consisted of 64 blacklights and a <TEX>$5.8m^3$</TEX> reaction bag made of Teflon film. Air temperature was controlled by an air-conditioning system. The starting time for rapid conversion of NO to <TEX>$NO_2$</TEX> was slightly delayed with decreasing air temperature. In contrast to light intensity effect, the ozone formation time and the ozone production rate were insensitive to air temperature. Although the formation time for secondary organic aerosols was not changed, the particle number concentration increased with temperature. However, the newly formed secondary organic aerosol mass at lower temperature was higher than that at higher temperature. Since light intensity significantly affected the starting time and quantity of ozone and aerosol formation, it is considered that the temperature could contribute partly the quantity of aerosol formation during the photooxidation of toluene-<TEX>$NO_x$</TEX>-air mixtures.
Antibiotics: Conflict and Communication in Microbial Communities (2014)

The discovery that microbes produce antibiotic compounds that kill or inhibit other microbes revolutionized modern medicine by offering a means to treat microbial infections. Thus, the “golden age” of antibiotic discovery began when hundreds of antibiotics from diverse microbial genera were characterized for their efficacy in controlling pathogens and the infections they cause. When used at subinhibitory concentrations, however, antibiotics can alter microbial gene expression, suggesting that they also act as signaling compounds.
Robust H ∞ control of Hamiltonian system with uncertainty (2012)

This paper investigates the robust H ∞ problem for a class of generalized forced Hamiltonian systems with uncertainties. The robust L 2-gain was proved for the Hamiltonian with a sufficient condition for stable control of multimachine power systems expressed as a matrix algebraic inequality. A similar sufficient condition was then extended to the robust H ∞ control of Hamiltonian systems to construct the state feedback H ∞ control law. A numerical example is given to verify the validity of the proposed control scheme, which shows the effectiveness and promising application of the method.
Anne Staquet, Descartes et le libertinage, 2009 (2011)

Ruby Christian. Anne Staquet, Descartes et le libertinage, 2009. In: Raison présente, n°179, 3e trimestre 2011. Arts et sciences. pp. 138-139.
Paradoxical Actions of Endogenous and Exogenous Insulin-like Growth Factor-binding Protein-5 Revealed by RNA Interference Analysis (2004)

Insulin-like growth factor-binding protein-5 (IGFBP-5) is abundantly expressed in bone cells. To determine the physiological role(s) of endogenous IGFBP-5 in regulating bone cell growth, differentiation, and survival, we used short double-stranded RNA (siRNA) to trigger RNA interference of IGFBP-5 in human osteosarcoma cells. The IGFBP-5 siRNA, targeting against a sequence unique to the IGFBP-5 middle domain, efficiently reduced IGFBP-5 mRNA and protein levels. The IGFBP-5 siRNA did not change the levels of IGFBP-4, a structurally related protein, or glyceraldehyde-3-phosphate dehydrogenase, a housekeeping gene. Knock-down of IGFBP-5 resulted in a significant increase in the number of transferase-mediated dUTP nick end labeling-positive cells and a decrease in a bone differentiation parameter (alkaline phosphatase activity) but had little effect on basal or insulin-like growth factor I-induced proliferation. Overexpression of a siRNA-resistant IGFBP-5 mutant in the IGFBP-5 knock-down cells restored the levels of survival to the control level; overexpression of IGFBP-4 or wild type IGFBP-5 had no such effect. Paradoxically, the addition of exogenous IGFBP-5 not only failed to rescue IGFBP-5 knock-down-induced apoptosis, it caused a further increase in apoptosis. Furthermore, the addition of exogenous IGFBP-5 alone increased apoptosis. This pro-apoptotic action of exogenous IGFBP-5 was abolished when IGF-I was added in excess, suggesting that exogenous IGFBP-5 increases apoptosis by binding to and inhibiting the activities of insulin-like growth factors. These results indicate that endogenous and exogenous IGFBP-5 exhibits opposing biological actions on cell survival and underscore the necessity and utility of studying IGFBP functions through loss-of-function approaches.
Multifunctional carbon nanotube composite fibers: Properties and electronic textileapplications (2014)

Work presented at the 25th International Conference on Diamond and Carbon Materials, 7th-11th september 2014, Madrid (Spain)
Temperature activation of courtship behavior in the male red-sided garter snake (Thamnophis sirtalis parietalis): Role of the anterior hypothalamus-preoptic area. (1987)

Adult male red-sided garter snakes (Thamnophis sirtalis parietalis) received radio-frequency lesions prior to 17 weeks of low-temperature hibernation. Animals found to have bilateral lesions of the anterior hypothalamus-preoptic area (AH-POA) failed to exhibit courtship behavior on emergence from hibernation. Those individuals in which the major portion of the destruction was centered in the anterior POA also exhibited deficits in thermoregulatory behavior. Animals that received unilateral lesions of the AH-POA initiated courtship behavior after controls and had an abbreviated period of courtship; these animals exhibited normal responses to thermal stimuli. Male snakes with lesions outside the AH-POA courted normally and demonstrated no differences in thermoregulatory behavior compared with the surgical controls. These results indicate that in male red-sided garter snakes, an intact AH-POA is critical for the integration of thermal stimuli that activate seasonal courtship behavior.
Glycation of Wild‐Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species (2015)

Protein glycation is a non-enzymatic, irreversible modification of protein amino groups by reactive carbonyl species leading to the formation of advanced glycation end products (AGEs). Several proteins implicated in neurodegenerative diseases have been found to be glycated in vivo and the extent of glycation is related to the pathologies of the patients. Although it is now accepted that there is a direct correlation between AGEs formation and the development of neurodegenerative diseases related to protein misfolding and amyloid aggregation, several questions still remain unanswered: whether glycation is the triggering event or just an additional factor acting on the aggregation pathway. We have recently shown that glycation of the amyloidogenic W7FW14F apomyoglobin mutant significantly accelerates the amyloid fibrils formation providing evidence that glycation actively participates to the process. In the present study, to test if glycation can be considered also a triggering factor in amyloidosis, we evaluated the ability of different glycation agents to induce amyloid aggregation in the soluble wild-type apomyoglobin. Our results show that glycation covalently modifies apomyoglobin and induces conformational changes that lead to the formation of oligomeric species that are not implicated in amyloid aggregation. Thus, AGEs formation does not trigger amyloid aggregation in the wild-type apomyoglobin but only induce the formation of soluble oligomeric species able to affect cell viability. The molecular bases of cell toxicity induced by AGEs formed upon glycation of wild-type apomyoglobin have been also investigated.
19F Hyperpolarization of 15N-3-19F-Pyridine via Signal Amplification by Reversible Exchange (2018)

We report synthesis of <sup>15</sup>N-3-<sup>19</sup>F-pyridine via Zincke salt formation with the overall 35% yield and 84% <sup>15</sup>N isotopic purity. Hyperpolarization studies of Signal Amplification by Reversible Exchange (SABRE) and SABRE in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) were performed to investigate the mechanism of polarization transfer from parahydrogen-derived hydride protons to <sup>19</sup>F nucleus in milli-Tesla and micro-Tesla magnetic field regimes in <sup>15</sup>N-3-<sup>19</sup>F-pyridine and <sup>14</sup>N-3-<sup>19</sup>F-pyridine. We found the mismatch between <sup>15</sup>N and <sup>19</sup>F magnetic field hyperpolarization profiles in the micro-Tesla regime indicating that the spontaneous hyperpolarization process likely happens directly from parahydrogen-derived hydride protons to <sup>19</sup>F nucleus without spin-relaying via <sup>15</sup>N site. In case of SABRE magnetic field regime (milli-Tesla magnetic field range), we found that magnetic field profiles for <sup>1</sup>H and <sup>19</sup>F hyperpolarization are very similar, and <sup>19</sup>F polarization levels are significantly lower than <sup>1</sup>H SABRE polarization levels and lower than <sup>19</sup>F SABRE-SHEATH (i.e. obtained at micro-Tesla magnetic field) polarization levels. Our findings support the hypothesis that in milli-Tesla magnetic field regime, the process of <sup>19</sup>F nuclei hyperpolarization is relayed via protons of substrate, and therefore is very inefficient. These findings are important in the context of improvement of the hyperpolarization hardware and rational design of the hyperpolarized molecular probes.
Paired immunoglobulin‐like receptors and their MHC class I recognition (2005)

The immunoglobulin-like receptors provide positive and negative regulation of immune cells upon recognition of various ligands, thus enabling those cells to respond properly to extrinsic stimuli. Murine paired immunoglobulin-like receptor (PIR)-A and PIR-B, a typical receptor pair of the immunoglobulin-like receptor family, are expressed on a wide range of cells in the immune system, such as B cells, mast cells, macrophages and dendritic cells, mostly in a pair-wise fashion. The PIR-A requires the homodimeric Fc receptor common gamma chain for its efficient cell-surface expression and for the delivery of an activation signal. In contrast, PIR-B inhibits receptor-mediated activation signals in vitro upon engagement with other activating-type receptors, such as the antigen receptor on B cells and the high-affinity Fc receptor for immunoglobulin E on mast cells. Recent identification of major histocompatibility complex (MHC) class I molecules as the physiological ligands for PIR has enabled us to attribute various immunological phenotypes observed in PIR-B-deficient mice to the consequences of the absence of a balanced interaction between PIR and MHC class I molecules expressed ubiquitously. Thus, PIR-A and PIR-B constitute a novel and physiologically important MHC class I recognition system.