gebhart/patrepeval huggingface dataset:
Efficacy of a Mobile Social Networking Intervention in Promoting Physical Activity: Quasi-Experimental Study (Preprint) (2018)

<sec> <title>BACKGROUND</title> Technological interventions such as mobile apps, Web-based social networks, and wearable trackers have the potential to influence physical activity; yet, only a few studies have examined the efficacy of an intervention bundle combining these different technologies. </sec> <sec> <title>OBJECTIVE</title> This study aimed to pilot test an intervention composed of a social networking mobile app, connected with a wearable tracker, and investigate its efficacy in improving physical activity, as well as explore participant engagement and the usability of the app. </sec> <sec> <title>METHODS</title> This was a pre-post quasi-experimental study with 1 arm, where participants were subjected to the intervention for a 6-month period. The primary outcome measure was the difference in daily step count between baseline and 6 months. Secondary outcome measures included engagement with the intervention and system usability. Descriptive and inferential statistical tests were conducted; posthoc subgroup analyses were carried out for participants with different levels of steps at baseline, app usage, and social features usage. </sec> <sec> <title>RESULTS</title> A total of 55 participants were enrolled in the study; the mean age was 23.6 years and 28 (51%) were female. There was a nonstatistically significant increase in the average daily step count between baseline and 6 months (mean change=14.5 steps/day, P=.98, 95% CI –1136.5 to 1107.5). Subgroup analysis comparing the higher and lower physical activity groups at baseline showed that the latter had a statistically significantly higher increase in their daily step count (group difference in mean change from baseline to 6 months=3025 steps per day, P=.008, 95% CI 837.9-5211.8). At 6 months, the retention rate was 82% (45/55); app usage decreased over time. The mean system usability score was 60.1 (SD 19.2). </sec> <sec> <title>CONCLUSIONS</title> This study showed the preliminary efficacy of a mobile social networking intervention, integrated with a wearable tracker to promote physical activity, particularly for less physically active subgroups of the population. Future research should explore how to address challenges faced by physically inactive people to provide tailored advices. In addition, users’ perspectives should be explored to shed light on factors that might influence their engagement with the intervention. </sec>
[Familial deficiency of C7 associated with adrenomyeloneuropathy]. (1994)

A 24-year old man presented with recurrent meningitis resulting from familial deficiency of a late component of the complement system (C7). Five years later, he developed gait disturbance, mental impairment and loss of hearing. Adrenomyeloneuropathy was diagnosed by a raised plasma long chain fatty acids level.
Characteristic temperature of quantum dot laser (1997)

The characteristic temperature of a quantum dot laser, T0, has been calculated for the first time considering carrier recombination in the optical confinement layer and violation of the charge neutrality in QDs. T0 is shown to fall off profoundly with increasing temperature, which is in line with the available experimental results.
Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma (2023)

Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
The measurement of seismographic records using a computer-controlled film scanner (1975)

abstract A semi-automatic system to digitize seismographic records is described. Photographic images of the records are digitized using a cathode-ray-tube film scanner that is controlled by a computer. An operator, interacting with the computer through a display console, supervises the overall data collection and can intervene in the search for traces and in the digitization of the data whenever he feels that it is necessary.
Recombinant Human Decorin Inhibits TGF-b1 Induced Contraction of Collagen Lattice by Keloid Fibroblasts. (2009)

﻿While wound contraction plays an important role in healing, it may lead to excessive scar formation and pathological wound contracture in extreme conditions. To date, the key regulator of wound contraction and keloid formation is transforming growth factor-beta (TGF-b1). Decorin has been reported to bind TGF-b1 and neutralize some of its activities. The present study investigated whether decorin affected TGF-b1-induced fibroblast contractile activity by using fibroblast-populated collagen lattice (FPCL), which has been generally used as an in-vitro model thought to mimic wound contraction in vivo, modified by the incorporation of recombinant human decorin into collagen gel. As expected, TGF-b1 significantly enhanced the contraction of collagen gel at hour 12, 24, 48, 72, and 96 (P < 0.05). Recombinant human decorin inhibited both the basal and TGF-b1-enhanced contraction of collagen gel by keloid fibroblasts (P < 0.05). These inhibitory effects of recombinant human decorin were associated with suppression of TGF-b1-induced filamentous actin (F-actin) expression in keloid fibroblasts. Furthermore, recombinant human decorin inhibited TGF-b1 induced a-smooth muscle actin (a-SMA), PAI-1 (plasminogen activator inhibitor-1) protein, and mRNA expressions in keloid fibroblasts (P < 0.05). These data indicate that recombinant human decorin can suppress TGF-b1-induced contraction of collagen gel by keloid fibroblasts. Moreover, decorin can inhibit basal contraction of collagen gel by keloid fibroblasts. These results suggest that decorin may have therapeutic potential for excessive skin contraction as observed in a keloid. ﻿.
In vivo clearance studies of the terminal fluid-phase complement complex in rabbits. (1989)

The present study was directed at obtaining information on the in vivo elimination rate of SC5b-9, the terminal fluid-phase product of complement activation. A sandwich ELISA based on the use of mono- and polyclonal antibodies was constructed that permitted quantitation of rabbit SC5b-9 in plasma. Rabbit serum was activated with inulin in vitro to generate SC5b-9, and the activated serum was applied intravenously in normal and C6-deficient rabbits. Elimination of SC5b-9 in normal rabbits was rapid, half-life in the range of 30-50 min. No differences were noted between the clearance of homologous rabbit and heterologous human SC5b-9, SC5b-9 concentrations returned to basal levels 2-3 h after application. Plasma of C6-deficient rabbits contained no SC5b-9 and these animals displayed an even more effective clearance capacity for the complex. Quantitative considerations indicated that basal plasma SC5b-9 levels in healthy animals result from a spontaneous turnover rate of approximately 0.2% of C5-C9 components per h. When multiple doses of SC5b-9 were injected in sequence, the same half-life and total elimination time were found as with single-dose experiments. The results demonstrate the existence of an effective clearance mechanism for SC5b-9, consistent with recent findings that SC5b-9 plasma levels are very low not only in healthy adults, but also in the majority of patients with complement-consuming diseases.
Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves (2013)

Glutaraldehyde cross-linked bioprosthetic heart valves fail within 12-15 years of implantation due to limited durability. Glutaraldehyde does not adequately stabilize extracellular matrix components such as glycosaminoglycans and elastin, and loss of these components could be a major cause of degeneration of valve after implantation. We have shown earlier that neomycin-based cross-linking stabilizes glycosaminoglycans in the tissue but fails to stabilize elastin component. Here, we report a new treatment where neomycin and pentagalloyl glucose (PGG) were incorporated into glutaraldehyde cross-linking neomycin-PGG-Glutaraldehyde (NPG) to stabilize both glycosaminoglycans and elastin in porcine aortic valves. In vitro studies demonstrated a marked increase in extracellular matrix stability against enzymatic degradation after cross-linking and 10 month storage in NPG group when compared to glutaraldehyde controls. Tensile properties showed increased lower elastic modulus in both radial and circumferential directions in NPG group as compared to glutaraldehyde, probably due to increased elastin stabilization with no changes in upper elastic modulus and extensibility. The enhanced extracellular matrix stability was further maintained in NPG-treated tissues after rat subdermal implantation for three weeks. NPG group also showed reduced calcification when compared to glutaraldehyde controls. We conclude that NPG cross-linking would be an excellent alternative to glutaraldehyde cross-linking of bioprosthetic heart valves to improve its durability.
Ushering in the next generation of precision trials for pediatric cancer (2019)

Cancer treatment decisions are increasingly based on the genomic profile of the patient's tumor, a strategy called "precision oncology." Over the past few years, a growing number of clinical trials and case reports have provided evidence that precision oncology is an effective approach for at least some children with cancer. Here, we review key factors influencing pediatric drug development in the era of precision oncology. We describe an emerging regulatory framework that is accelerating the pace of clinical trials in children as well as design challenges that are specific to trials that involve young cancer patients. Last, we discuss new drug development approaches for pediatric cancers whose growth relies on proteins that are difficult to target therapeutically, such as transcription factors.
User Profiling in FPGA for Intrusion Detection Systems (2010)

This work elaborates the implementation and the use of dedicated hardware in computer network security. The novel FPGA implementation for user profiling in intrusion detection systems, provides new potential which can further lead to better performances and more reliable security systems. The results yield a promising future for these systems and overcome many speed drawbacks and disadvantages of already existing algorithms as well as platform for development the new, original ones.
Bag of Tricks and A Strong Baseline for Deep Person Re-identification (2019)

This paper explores a simple and efficient baseline for person re-identification (ReID). Person re-identification (ReID) with deep neural networks has made progress and achieved high performance in recent years. However, many state-of-the-arts methods design complex network structure and concatenate multi-branch features. In the literature, some effective training tricks are briefly appeared in several papers or source codes. This paper will collect and evaluate these effective training tricks in person ReID. By combining these tricks together, the model achieves 94.5% rank-1 and 85.9% mAP on Market1501 with only using global features. Our codes and models are available at https://github.com/michuanhaohao/reid-strong-baseline.
Public health, Egypt (2020)

Abstract No specific account has survived of the organization of a public health service in Pharaonic Egypt; however, some system of community medicine or state‐sponsored medical treatment probably existed. Discovered in a pyramid workmen's town (ca. 1880 bce ), Papyrus Kahun marks a significant early contribution to community medicine. Despite environmental conditions and population movements conducive to epidemics, there is no firm evidence of widespread plagues, possibly because the population was too small. Public or private support provided medical and social care for the sick, disabled, and elderly. Contemporary societies rejected those with physical anomalies, whereas the Egyptians integrated them into society.
Detection of Specific Building in Remote Sensing Images Using a Novel YOLO-S-CIOU Model. Case: Gas Station Identification (2021)

The specific building is of great significance in smart city planning, management practices, or even military use. However, traditional classification or target identification methods are difficult to distinguish different type of buildings from remote sensing images, because the characteristics of the environmental landscape around the buildings (like the pixels of the road and parking area) are complex, and it is difficult to define them with simple rules. Convolution neural networks (CNNs) have a strong capacity to mine information from the spatial context and have been used in many tasks of image processing. Here, we developed a novel CNN model named YOLO-S-CIOU, which was improved based on YOLOv3 for specific building detection in two aspects: (1) module Darknet53 in YOLOv3 was replaced with SRXnet (constructed by superimposing multiple SE-ResNeXt) to significantly improve the feature learning ability of YOLO-S-CIOU while maintaining the similar complexity as YOLOv3; (2) Complete-IoU Loss (CIoU Loss) was used to obtain a better regression for the bounding box. We took the gas station as an example. The experimental results on the self-made gas station dataset (GS dataset) showed YOLO-S-CIOU achieved an average precision (AP) of 97.62%, an F1 score of 97.50%, and had 59,065,366 parameters. Compared with YOLOv3, YOLO-S-CIOU reduced the parameters' number by 2,510,977 (about 4%) and improved the AP by 2.23% and the F1 score by 0.5%. Moreover, in gas stations detection in Tumshuk City and Yanti City, the recall (R) and precision (P) of YOLO-S-CIOU were 50% and 40% higher than those of YOLOv3, respectively. It showed that our proposed network had stronger robustness and higher detection ability in remote sensing image detection of different regions.
Abstract 14308: Integrative Epigenomic Analysis Identifies Enhancer Modifying Variants Linked to Cardiomyopathy Genes (2020)

Introduction: Inherited cardiomyopathy is caused by mutations in more than 100 genes. A well-recognized clinical feature of genetic cardiomyopathy is varying phenotypic expression. Even with identical primary mutations, there is a range of clinical outcomes. Genetic variants in protein coding regions have been shown to alter the phenotypic expression of primary cardiomyopathy-causing mutations. However, the contribution of noncoding variation has been less well studied. Methods and Results: We used an integrative analysis of &gt;20 publicly-available heart enhancer function and enhancer target datasets to identify genomic regions predicted to regulate the cardiomyopathy genes, MYH7 and LMNA . We identified two candidate enhancer clusters around the MYH7 gene and three clusters around the LMNA gene. We tested enhancers in these clusters using reporter assays and CRISPr-mediated deletion in human cardiomyocytes derived from induced pluripotent stem cells (iCMs). We identified a super enhancer upstream of MYH7 that is necessary for high MYH7 expression in iCMs. These regulatory regions contained sequence variants within transcription factor binding sites that altered enhancer function. We created an informatic pipeline that extended this strategy genomewide to identify an additional enhancer modifying variant upstream of MYH7 . This variant disrupts a transcription factor binding site upstream of MYH7 and limits MYH7 upregulation. We extended these analyses by examining clinical correlates, finding that this variant correlated with a more dilated left ventricle over time in patients with cardiomyopathy. Conclusions: We identified two enhancer regions important for MYH7 expression in iCMs. These enhancer regions may be utilized to induce MYH7 during human development and heart failure. MYH7 changes in heart failure have been linked to cardiomyopathy phenotypes. The variant upstream of MYH7 likely alters these changes and results in a more severe phenotype. These findings demonstrate that noncoding variants have clinical utility and targeted assessment of noncoding modifiers may become integrated into clinical care.
A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation. (1985)

Axons of dorsal root ganglion neurons express on their surfaces one or more proteins which are mitogenic for Schwann cells (Salzer, J., R. P. Bunge, and L. Glaser, 1980, J. Cell Biol., 84:767-778). Incubation of co-cultures of dorsal root ganglion neurons and Schwann cells with 4-methylumbelliferyl-beta-D-xyloside, an inhibitor of proteoglycan biosynthesis, decreases the mitogenic response of the Schwann cell by over 95%. The effect of the beta-D-xyloside has been localized to the neurons; pretreatment of neurons but not of Schwann cells with the inhibitor causes a marked reduction of the mitogenic response. In addition, Schwann cells treated with beta-D-xyloside are still mitogenically responsive to soluble Schwann cell mitogens (cholera toxin and glial growth factor). Neurons treated with heparitinase and membrane vesicles prepared from heparitinase-treated neurons show diminished mitogenicity for Schwann cells, while other proteoglycan lyases have no effect. We conclude that a cell surface heparan sulfate proteoglycan is a component of the Schwann cell mitogen present on the surface of dorsal root ganglion neurons.
The application of fiber optic technology to flowmeters (1989)

Abstract : A survey of flow measurement techniques was carried out to assess the potential of a flowmeter using fiber optic sensing technology. The coriolis mass flow sensing technique was identified as being the most promising, and an optically-powered experimental version employing fiber optic sensors was constructed and tested. The experimental flowmeter exhibited encouraging performance and further development, by a manufacturer experienced in Coriolis flowmeter design,is recommended. Keywords: Flowmeters; Coriolis; Fiber optics; Fiber sensors.
Bell's inequalities revisited (2017)

The entanglement phenomenon challenges our human way of thinking. As of today, while quantum statistical mathematics predicts correctly the behaviours of entangled particles non-statistical mathematics fails to concur with experiments. This paper overcomes this challenge. A new non-statistical equation is introduced, replacing the one that fails; this non-statistical equation is justified by physical experiments just as quantum statistical mathematics is. The valid non-statistical equation proposed here describes each individual particle’s specific behavior and subsequent measurement, a feature missing in quantum statistical mechanics. And for perplexed scientists, it is shown how this valid non-statistical mathematics metamorphoses Bell’s inequalities into equalities.
Progress of THz quantum cascade laser using nitride semiconductor (2016)

We demonstrate the first lasing operation of GaN-based quantum cascade lasers (QCLs). Nitride semiconductor is a material having a potential for realizing wide QCL frequency range including unexplored frequency from 5 to 12 THz, as well as realizing room temperature operation. We fabricated GaN/AlGaN THz-QCLs with novel pure-3-level design active region by molecular beam epitaxy (MBE). A 5.4 THz lasing was obtained from the QCL measured at 5.6K. We also obtained 6.97 THz lasing of the QCL fabricated by metal-organic chemical vapor deposition (MOCVD).
Biological Approaches to Rational Drug Design (2021)

Identifying Lead Peptides from Epitope Libraries, J.K. Scott Interleukin-1 Receptor Pathway Approaches to Drug Design, H.M. Einspahr, B.C. Finzel, and D.E. Tracey The Hematopoietic Colony-Stimulating Factors, K. Kaushansky Monoclonal Antibodies: Technical Development and Therapeutic Indications, M.R. Dalesandro, M.E. Sanders, and J.A. Lipani T Cell Receptor-Based Therapy of Autoimmune Diseases, T. Ramanujam and W.V. Williams Oligosaccharide Pharmaceuticals, S. Roth and D. Zopf Gene Therapy, J.D. Boyer and D.B. Weiner Antisense Deoxynucleotides and Ribozymes: Mechanisms of Action and Potential in Gene Therapy, S.K. Shore and E.P. Reddy Index
Vibration Tolerance in Optical Imaging (1989)

The effects of object-to-image vibration are studied with the purpose to quantitatively define the maximum acceptable vibration level as a function of resolution, linewidth control, exposure and focus tolerances, proximity condition, and illumination coherence. The exposure-defocus trees and windows of optically projected images are used to derive the vibration tolerance as well as the optimum exposure as a function of vibration amplitude. Dimensionless variables for resolution, focus and exposure are used so that the results are universally applicable for any given diffraction-limited lens system.
Achieving simultaneous nitrification and denitrification of wastewaters at reduced cost (1995)

The Orbal process for the treatment of waste waters, claims simultaneous nitrification and denitrification in the outer lane in the presence of a dissolved oxygen concentration of 1.5 mg/l. The potential of this process is to offer both a reduced cost and simplified operation for nitrogen removal in the Mediterranean environment. The objective of this work was to investigate these claims and attempt to describe a mechanism for the experimental verifications. Using mixed cultures grown in chemostats, simultaneous nitrification and denitrification was observed under oxic/anoxic cycling. A reduced pathway, or ‘nitrite shunt’ could not be demonstrated but it was possible to explain the observations based on the lag time of the denitrifiers under oxic conditions. Denitrification continued for some time before oxygen replaced nitrate as the terminal electron acceptor and the length of the lagged response was a function of the duration of the anoxic conditions.
Imaging Lung Disease in Systemic Sclerosis (2010)

Interstitial lung disease and pulmonary hypertension (PH) are the most common cardiopulmonary findings in patients with systemic sclerosis (SSc). About two thirds of patients suffering from SSc develop scleroderma interstitial lung disease. PH is present in about 20% of SSc patients and is typically associated with severe lung disease, although it may be an isolated manifestation of SSc. High-resolution CT scanning is a key method for evaluating chest involvement. There are four roles of imaging in scleroderma interstitial lung disease: 1) detection of lung involvement, 2) identification of patients likely to respond to treatment, 3) assessment of treatment efficacy, and 4) exclusion of other significant diseases to include PH and cardiac and esophageal abnormalities.
Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis (2009)

The lack of anti-LPL antibodies in Takayasu's disease implies distinct mechanisms underlying dyslipidemia compared to systemic lupus erythematosus.
Sélectivité du transport de Ca2+/Mg2+ à travers une membrane liquide par A•23187 (calcimycine) et son dérivé N-méthyle (1985)

Operating in a cell of water/CHCl 3 /water, it is shown that there is a preferential transport of Ca 2+ /Mg 2+ by A.23187. On the basis of measurements of flux of extraction and of flux of liberation in a half-cell of water/CHCl 3 , it is shown that the selectivity of the transport is related to the kinetics of liberation, which is markedly different for the two ions and which could be explained by the structure of the complex dimers that are formed, according to the corresponding crystallographic studies. The methylation of the —NHCH 3 entails an inversion of the selectivity in the transport