gebhart/patrepeval huggingface dataset:
LMS Algorithms for Multilinear Forms (2020)

Solving a high-dimension system identification problem could involve significant challenges in terms of complexity and accuracy of the solution. Due to the large parameter space, a decomposition-based approach fits very well in this context. This was the idea behind the recently developed iterative Wiener filter for multilinear forms, which reformulates the problem using a combination of shorter filters. Nevertheless, there are inherent limitations related to the Wiener solution, while the least-mean-square (LMS) adaptive filter would represent a more practical alternative. Consequently, in this paper, we develop LMS-based algorithms for multilinear forms, in the context of a multiple-input/single-output system identification problem. Simulation results indicate the good performance of the proposed algorithms, especially in terms of their fast convergence features.
Combination chemotherapy for advanced breast cancer.Two regimens containing adriamycin (1978)

Forty-eight women with advanced metastatic carcinoma of the breast were treated with one of two combination chemotherapy regimens: 1) adriamycin and cyclophosphamide or 2) adriamycin, cyclophosphamide, methotrexate and 5-fluorouracil. The response rate in the two-drug treatment group was 50% and in the four-drug treatment group, 55%. The median duration of response was ten months in both treatment groups. Dramatic responses were seen in patients with visceral metastases. Patients who responded to chemotherapy had a significantly longer survival than nonresponders (p less than 0.01). The long interval between adriamycin doses (six weeks) in the four drug regimen did not adversely effect the response rate--an important finding in view of the dose-related cardiac toxicity of this agent.
Insertion of Acetonitrile into the Zr−P Bond of [Cp°2ZrCl(PHCy)] (Cy = Cyclohexyl, Cp° = η5-C5EtMe4) Followed by PHCy Elimination To Give [Cp°2(Cl)Zr(μ-NCMe−CMeN)Zr(Cl)Cp°2] (1999)

[Cp°2ZrCl(PHCy)] (Cy = cyclohexyl, Cp° = η5-C5EtMe4) undergoes insertion of MeCN into the Zr−P bond, yielding [Cp°2ZrCl{NC(Me)(PHCy)}] (1). Isomers with a Z (1a) or E (1b) configuration at the C−N double bond are obtained in a ratio of 13:1. At room temperature, 1 slowly decomposes in solution with elimination of a PHCy fragment and formation of [Cp°2(Cl)Zr(μ-NCMe−CMeN)Zr(Cl)Cp°2] (2). Two isomers are obtained with a trans (2a) or cis (2b) arrangement around the C−N double bonds of the bridging butane-2,3-diimino(2-)-N,N‘ ligand. 1a, 2a, and 2b were isolated and characterized by IR, MS, and NMR spectroscopy (1H, 31P, 13C), and crystal structure determinations were carried out on 1a and 2a. In the solid state, the short Zr−N bonds and the almost linear Zr−N−C angles of 1a and 2a indicate the presence of Zr−N double bonds.
Guido/Mir - An Experimental Musical Information Retrieval System Based On Guido Music Notation. (2001)

[TODO] Add abstract here.
Porous Hybrids: MOF Nano‐Vesicles and Toroids: Self‐Assembled Porous Soft‐Hybrids for Light Harvesting (Adv. Funct. Mater. 45/2013) (2013)

Nature employs light-harvesting complexes for efficient migration of photons to the reaction centre for the conversion of solar energy to chemical energy. Mimicking this natural process of energy transfer in a synthetic light-harvesting system is demonstrated by V. M. Suresh, S. J. George, and T. K. Maji in a functional nanoscale soft-porous luminescent metal–organic framework. On page 5585, coordination-directed self-assembly of a chromophoric organic linker results in ordered metal-organic vesicular and toroid nanostructures that act as a light-harvesting scaffold for noncovalently entrapped dye molecules.
Eotaxin is required for the baseline level of tissue eosinophils (1998)

Eotaxin is an eosinophil-selective chemokine that is constitutively expressed in a variety of organs such as the intestine. Previous studies have demonstrated that the recruitment of eosinophils during inflammation is partially dependent on eotaxin, but the function of constitutive eotaxin during homeostasis has not been examined. To elucidate the biological role of this molecule, we now examine tissue levels of eosinophils in healthy states in wild-type and eotaxin-deficient mice. The lamina propria of the jejunum of wild-type mice is demonstrated to express eotaxin mRNA, but not mRNA for the related monocyte chemoattractant proteins. Wild-type mice contained readily detectable eosinophils in the lamina propria of the jejunum. In contrast, mice genetically deficient in eotaxin had a large selective reduction in the number of eosinophils residing in the jejunum. The reduction of tissue eosinophils was not limited to the jejunum, because a loss of thymic eosinophils was also observed in eotaxin-deficient mice. These studies demonstrate that eotaxin is a fundamental regulator of the physiological trafficking of eosinophils during healthy states. Because a variety of chemokines are constitutively expressed, their involvement in the baseline trafficking of leukocytes into nonhematopoietic tissue should now be considered.
Effects of Surface Chemistry on Cytotoxicity, Genotoxicity, and the Generation of Reactive Oxygen Species Induced by ZnO Nanoparticles (2010)

The relationship between the toxicity of zinc oxide (ZnO) nanoparticles (NPs) and their surface chemistry was investigated. Cytotoxicity, genotoxicity, and the ability to generate reactive oxygen species (ROS) were assessed for well-characterized ZnO NPs whose surface chemistry was varied from its pristine state by coating with oleic acid (OA), poly(methacrylic acid) (PMAA), or components adsorbed from cell culture medium (medium-soaked). It was found that uncoated NPs showed ROS accumulation and diminished cell viability whereas all tested surface coatings assisted in reducing ROS production and cytotoxicity. The ability of coatings to reduce the cytotoxicity of ZnO NPs was ranked in the following order: medium-soaked ≈ PMAA > OA. However, PMAA-coated ZnO had significant genotoxicity compared to uncoated ZnO and the other coated NPs, highlighting the need to investigate thoroughly the effects of NP surface modification on both cytotoxicity and genotoxicity assays. The lowest toxicity was achieved with a surface coating of components from a cell culture medium.
The design of a remote meter acquisition module based on 6LoWPAN (2016)

Smart meter, as a key part of the smart grid, is responsible for collecting the user characteristics in the advanced metering infrastructure. As more and more applications have been upgraded to the IPv6 protocol, 6LoWPAN can potentially replace the ZigBee as the standard protocol in the “Internet of Things” area. Representing an application of IPv6 technology in the smart metering, this article introduces the design of an electricity information acquisition module. With STM32 microprocessor and SI4432 RF transmitter/receiver embedded in this module, a LAN has been set up for the data transmission based on the 6LoWPAN. The individual and system tests of this advanced module have shown its robustness, interference immunity, high network stability and lower power consumption comparing with other modules with different hardware and operating systems.
Oxygen loss and the conversion of coal (1985)

Bituminous coal conversions in CO/water at 400/sup 0/C have demonstrated that O-loss and conversion (toluene solubility) are not directly related. About half the coal oxygen is consistently lost over a range of conversions, from virtually no conversion to yields up to 50%. While loss is from the nonphenolic oxygen in the coal, it is difficult to reconcile these results with the common view that ether cleavage is a key conversion step. 8 refs., 2 tabs.
Selective endothelial dysfunction in early atheroma-like lesions in the rabbit (1992)

Background: The general aim of this study was to use the collar model of atherosclerosis to investigate the extent to which endothelial cell function is impaired at the early stages of lesion development and to determine whether other mechanisms of vascular control at the level of the smooth muscle might be disrupted by the development of these lesions. Methods: Atheroma-like lesions that mimic the events of early human atherosclerosis were induced in rabbits by placing flexible, nonocclusive collars around each common carotid artery. The arterial responsiveness to vasodilator drugs was studied in isolated rings from the arteries both before morphologic changes would be evident (2 days after surgery) and when intimal thickening was evident (7 days after surgery). Results: Relaxation responses to the endothelium-dependent vasodilator acetylcholine were significantly weaker in arterial segments from the center collar (cuffed arteries) than in control segments taken both 2 or 7 days after surgery. In contrast, sodium nitroprusside, an endothelium-independent vasodilator caused no impairment of relaxation. Cuffed and control arterial segments had no difference in relaxation response to two other endothelium-dependent vasodilators, adenosine triphosphate, and the calcium ionophore A23187, at either 2 or 7 days after surgery. High concentrations of acetylcholine elicited contractions in cuffed rings that were denuded of endothelium, but these were not significantly different from those of control rings. Similarly, in rings treated with N-nitro-L-arginine, the contractions of cuffed rings did not differ significantly from those of control rings. Conclusions: The development of atheroma-like lesions results in the specific impairment of acetylcholine-induced relaxation before the intima has thickened, which suggests muscarinic receptor dysfunction. In contrast, vascular smooth muscle relaxation is normal, and some vasoconstrictor mechanisms are enhanced.
Homology-dependent Suppression of Stigma Phenotype by an Antisense S-locus Glycoprotein (SLG) Gene in Brassica rapa L. (2001)

Self-incompatibility (SI) in Brassicaceae is sporophytically controlled by haplotypes of the polymorphic S locus complex. Two tightly linked polymorphic genes at the S locus, S-locus glycoprotein (SLG) and S-receptor kinase (SRK) genes, are specifically expressed in the stigma. S-haplotypes have been classified into class I and class II types based on the sequence similarity of their SLGs, and their SRKs. To investigate the effect of an antisense SLG gene on the class divergency of the endogenous SLG and SRK genes, we introduced an antisense class I SLG43 cDNA into a cultivar Osome in Brassica rapa which was heterozygous for class I S52 haplotype and class II S60. SLG43 is more similar to the endogenous SLG52 (87.8% identity) than to SLG60 (74.8% identity), Out of ten primary transformants analyzed, two were completely self-compatible; the SI phenotype of stigma was altered from S52S60 to S60, but that of pollen was not. In these two plants, the expression levels of mRNA and protein of SLG52 were reduced, whereas those of SLG60 were not. We suggest that an antisense class I SLG-transgene causes homology-dependent suppression, which leads to breakdown of the class I S-haplotype specificity in stigma but not the class II S-haplotype.
FY 88 laser transport experiments on ATA (Advanced Test Accelerator) (1988)

An experiment was conducted at the Advanced Test Accelerator (ATA) in the spring/summer of 1988 to study the transport of the ''laser guided'' electron beam through the accelerator and beyond. The electron beam was guided from the /approximately/3.75 MeV point through the accelerator on an ion channel created by firing a KrF laser (248 nm, P approx.100--400 mJ) into a benzene filled (p approx..1 ..mu..) beamline. Beam transport was documented at several locations with a variety of diagnostics for various beam parameters; channel, gas, and laser parameters; and for various machine configurations. The focus of this experiment was to document, understand, and then alter (remove) the time variation in the observed accelerated beam parameters. The temporal variation of the beam manifests itself in several ways as has been documented. Beam radius versus time, R(t), from both bow probe and optical data shows the beam radius expanding by factors of up to several over the 40 ns of beam pulse. When the beam is threaded through any device with a limited acceptance the radius variation is parlayed into a current variation, I(t). This has been documented for transport through the fusible link, rise time sharpener, slits, bends, emittance selectors, and duringmore » free expansion. The beam temporal variation in time may be viewed as radius increase or blowup, brightness degradation, or emittance increase. The observations of blowup predate the introduction of the collimator. The observations prior to this experiment were made in the post accelerator transport sections. 9 refs., 4 figs.« less
The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase I (1990)

cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left arm of the second chromosome at position 28D2-4. The deduced amino acid sequence (309 residues) of Drosophila PP2A shows 94% identity with either rabbit PP2A alpha or PP2A beta, indicating that PP2A may be the most conserved of all known enzymes.
A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis (2015)

Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neurological disease that primarily affects spinal cord anterior horn cells and their axons for which there is no treatment. Here we report the use of a recombinant natural human IgM that binds to the surface of neurons and supports neurite extension, rHIgM12, as a therapeutic strategy in murine models of human ALS. A single 200 µg intraperitoneal dose of rHIgM12 increases survival in two independent genetic-based mutant SOD1 mouse strains (SOD1G86R and SOD1G93A) by 8 and 10 days, delays the onset of neurological deficits by 16 days, delays the onset of weight loss by 5 days, and preserves spinal cord axons and anterior horn neurons. Immuno-overlay of thin layer chromatography and surface plasmon resonance show that rHIgM12 binds with high affinity to the complex gangliosides GD1a and GT1b. Addition of rHIgM12 to neurons in culture increases α-tubulin tyrosination levels, suggesting an alteration of microtubule dynamics. We previously reported that a single peripheral dose of rHIgM12 preserved neurological function in a murine model of demyelination with axon loss. Because rHIgM12 improves three different models of neurological disease, we propose that the IgM might act late in the cascade of neuronal stress and/or death by a broad mechanism.
The Effect of Surface Adsorption and Staining Reactions on the Antimicrobial Properties of Some Cationic Antiseptic Mouthwashes (1984)

The phenomenon of surface adsorption appears fundamental to the antiplaque activity of the cationic antiseptics. Moreover, reaction with chromogenic material is relevant to the local side effect of staining. The purpose of this investigation was to determine how such local reactions affect the antibacterial activity of some of these antiseptics. The minimum inhibitory concentration (MIC) of commercial mouthrinses containing alexidine, cetyl pyridinium chloride, chlorhexidine gluconate and hexetidine against Oxford staphylococcus (NCTC 6571) and Escherichia coli (NCTC 10418) was established by tube dilution. The effect on the MIC values against O. staphylococcus of adding polymethylmethacrylate polymer or against E coli of adding a standard tea solution was then measured. The zones of inhibition around acrylic blocks soaked in the respective antiseptics, with and without postexposure washings, were measured. The effects on zone width of placing the antiseptic-soaked blocks in tea were recorded. The MIC values of alexidine, cetyl pyridinium chloride and chlorhexidine gluconate, but not hexetidine, were all increased by adding polymethylmethacrylate to cultures. Tea added to the culture increased the MIC values against E. coli for alexidine, chlorhexidine and hexetidine, but not for cetyl pyridinium chloride. Zones of inhibition around antiseptic-treated blocks were reduced by washing and, in the case of hexetidine, completely abolished. Tea-soaking further reduced the zones of inhibition for alexidine and chlorhexidine, but not cetyl pyridinium chloride.(ABSTRACT TRUNCATED AT 250 WORDS)
Data from HEF1 Is a Crucial Mediator of the Proliferative Effects of Prostaglandin E<sub>2</sub> on Colon Cancer Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; (PGE&lt;sub&gt;2&lt;/sub&gt;), one of the downstream products of cyclooxygenase-2 enzymatic activity, promotes colorectal carcinogenesis in part by stimulating cell division. In this study, we define a critical mechanism in this process by showing that the prometastatic adapter protein human enhancer of filamentation 1 (HEF1; NEDD9) links PGE&lt;sub&gt;2&lt;/sub&gt; to the cell cycle machinery in colorectal cancer cells. PGE&lt;sub&gt;2&lt;/sub&gt; rapidly induced expression of HEF1 mRNA and protein in colorectal cancer cells. HEF1 overexpression elicited the same effects as PGE&lt;sub&gt;2&lt;/sub&gt; treatment on cell proliferation, cell cycle progression, and tumor growth. Conversely, HEF1 knockdown suppressed PGE&lt;sub&gt;2&lt;/sub&gt;-driven cell proliferation and cell cycle progression. Cell cycle alterations involved HEF1 fragmentation as well as co-distribution of HEF1 and cell cycle kinase Aurora A along spindle asters during cell division. Moreover, Aurora A co-immunoprecipitated with HEF1 and was activated by HEF1. Consistent with a role for HEF1 in colorectal carcinogenesis, we found elevated expression of HEF1 expression in 50% of human colorectal cancers examined, relative to paired normal tissues. These findings establish that PGE&lt;sub&gt;2&lt;/sub&gt; induces HEF1 expression, which in turn promotes cell cycle progression through its interaction with and activation of Aurora A. Further, they establish that HEF1 is a crucial downstream mediator of PGE&lt;sub&gt;2&lt;/sub&gt; action during colorectal carcinogenesis. Cancer Res; 70(2); 824–31&lt;/p&gt;&lt;/div&gt;
Modeling the Viral Kinetics of Influenza A During Infection in Humans (2022)

This study explores the natural control system in the body for responding to exposure to the Influenza A virus. More specifically, it delves into the development of a model to simulate the responses of target uninfected cell counts, infected cell counts, and viral titers. There are two particular models of interest: a delayed model that incorporates the brief inactive period for newly infected cells, and a non-delayed model reflecting only infected cells without delay after initial infection. Both models are commonly used in the literature and the benefits of each model are studied and explained. We generate Simulink models for both the delayed and non-delayed sets of ordinary differential equations (ODEs) to simulate responses to different viral titer impulses. Additionally, this study aims to extrapolate these models to the case for a vaccinated individual. To do this, we modify the viral clearance rate and infected cell death rate of our initial model to account for the improved immune response generated by vaccines.
1,3-Diketones from Acid Chlorides and Ketones:  A Rapid and General One-Pot Synthesis of Pyrazoles (2006)

[reaction: see text] 1,3-Diketones were synthesized directly from ketones and acid chlorides and were then converted in situ into pyrazoles by the addition of hydrazine. This method is extremely fast, general, and chemoselective, allowing for the synthesis of previously inaccessible pyrazoles and synthetically demanding pyrazole-containing fused rings.
Characterization of migrated seismic volumes using texture attributes: a comparative study (2015)

Summary In this paper, we examine several typical texture attributes developed in the image processing community in recent years with respect to their capability of characterizing a migrated seismic volume. These attributes are generated in either frequency or space domain, including steerable pyramid, curvelet, local binary pattern, and local radius index. The comparative study is performed within an image retrieval framework. We evaluate these attributes in terms of retrieval accuracy. It is our hope that this comparative study will help acquaint the seismic interpretation community with the many available powerful image texture analysis techniques, providing more alternative attributes for their seismic exploration.
Inégalités de covariance (2004)

Dans cette Note, nous montrons que certaines inégalités de covariance écrites en terme de coefficients de mélange restent vraies pour des versions faibles de ces coefficients. Nous donnons ensuite quelques exemples de processus non-mélangeants pour lesquels nous pouvons obtenir sans peine des bornes pour les coefficients faibles.
Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems (2000)

Making the histologic diagnosis of cirrhosis and hepatitis is usually an easy task, but not always. Many times, the cause of a fibrotic or inflammatory process in the liver can be difficult to recognize because the liver responds to a wide range of injuries in only a limited number of ways. However, certain patterns of injury and other microscopic features when applied in the appropriate clinical setting can help differentiate various causes of such processes.
Cystatin‐like domain of mouse countertrypin, a member of mammalian fetuin family, is responsible for the inhibition of trypsin. Evidence from site‐directed mutagenesis (1996)

Members of mammalian fetuin family, such as human alpha 2 HS glycoprotein and bovine fetuin, consist of three domains, two tandemly arranged cystatin-like domains and an unrelated domain, but they have no inhibitory activity against cysteine proteinases. We found that countertrypin, a novel trypsin inhibitor, is mouse counterpart of human alpha 2 HS glycoprotein, and that human alpha 2 HS glycoprotein and bovine fetuin which were prepared without use of ethanol are capable of inhibiting trypsin (Yamamoto, K. and Sinohara, H. (1993) J. Biol. Chem, 268, 17750-17753). In the present study, cDNA encoding countertrypin was isolated and sequenced, and evidence is presented, based on the site-directed mutagenesis, that lysine-231 in the second cystatin domain is the P1 site for trypsin inhibition.
Fabrication and Characterization of Tumor Nano-Lysate as a Preventative Vaccine for Breast Cancer (2020)

Breast cancer is the most common cancer among women in the United States, with late stages associated with the lowest survival rates. The latest stage, defined as metastasis, accounts for 90% of all cancer-related deaths. There is a strong need to develop antimetastatic therapies. TRAIL, or TNF-related apoptosis inducing ligand, has been used as an antimetastatic therapy in the past, and conjugating TRAIL to nanoscale liposomes has been shown to enhance its targeting efficacy. When circulating tumor cells (CTCs) released during metastasis are exposed to TRAIL-conjugated liposomes and physiologically relevant fluid shear stress, this results in rapid cancer cell destruction into cell fragments. We sought to artificially recreate this phenomenon using probe sonication to mechanically disrupt cancer cells and characterized the resulting cell fragments, termed "tumor nano-lysate", with respect to size, charge, morphology, and composition. Furthermore, an in vivo pilot study was performed to investigate the efficacy of tumor nano-lysate as a preventative vaccine for breast cancer in an immunocompetent mouse model.
Einfluß von Manschettenparametern auf die Indikatorentstehung bei der nichtinvasiven Blutdruckmessung nach dem Manschettenprinzip (1993)

Article Einfluß von Manschettenparametern auf die Indikatorentstehung bei der nichtinvasiven Blutdruckmessung nach dem Manschettenprinzip was published on January 1, 1993 in the journal Biomedical Engineering / Biomedizinische Technik (volume 38, issue s1).