gebhart/patrepeval huggingface dataset:
Development and Biological Assessment of Fully Water‐Soluble Helical Aromatic Amide Foldamers (2007)

Nicht biologisch, aber biologisch aktiv: Helicale Arylamid-Oligomere, die sich in ihren Strukturen deutlich von den α-Peptiden, β-Peptiden und Peptoiden unterscheiden, sind dennoch vergleichbar gut zellgängig, kaum toxisch und überdies absolut beständig gegen Zersetzung durch Proteasen. TFA−=Trifluoracetat. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z700301_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Creatine Supplementation Augments Skeletal Muscle Carnosine Content in Senescence-Accelerated Mice (SAMP8) (2008)

The histidine-containing dipeptides (HCD) carnosine and anserine are found in high concentrations in mammalian skeletal muscle. Given its versatile biologic properties, such as antioxidative, antiglycation, and pH buffering capacity, carnosine has been implicated as a protective factor in the aging process. The present study aimed to systematically explore age-related changes in skeletal muscles HCD content in a murine model of accelerated aging. Additionally, we investigated the effect of lifelong creatine supplementation on muscle HCD content and contractile fatiguability. Male senescence-accelerated mice (SAMP8) were fed control or creatine-supplemented (2% of food intake) diet from the age of 10 to 60 weeks. At week 10, 25, and 60, tibialis anterior muscles were dissected and analysed for HCD and taurine content by HPLC. Soleus and EDL muscles were tested for in vitro contractile fatigue and recovery. From 10 to 60 weeks of age, muscular carnosine (-45%), taurine (-24%), and total creatine (-42%) concentrations gradually and significantly decreased. At 25 but not at 60 weeks, oral creatine supplementation significantly increased carnosine (+88%) and anserine (+40%) content compared to age-matched control-fed animals. Taurine and total creatine content were not affected by creatine supplementation at any age. Creatine-treated mice showed attenuated muscle fatigue (soleus) and enhanced force recovery (m. extensor digitorum longus [EDL]) compared to controls at 25 weeks, but not at 60 weeks. From the present study, we can conclude that skeletal muscle tissue exhibits a significant decline in HCD content at old age. Oral creatine supplementation is able to transiently but potently increase muscle carnosine and anserine content, which coincides with improved resistance to contractile fatigue.
[The results of use of the antiadhesive seprafilm barrier in adhesive disease of abdomen]. (2011)

The results of treatment of 16 patients with abdominal adhesive disease are presented. In the surveyed group there were 7 women and 9 men. The average age of patients was 47,7 ± 14,0 (23-71). Mean duration of history of intestinal obstruction were 48,9 ± 31,5 (5-120) hours. 12 patients underwent surgery for acute adhesive small bowel obstruction. In 7 patients obturative and in 5 patients strangulated obstructions were revealed. In 9 patients laparoscopic resolution of obstruction was performed (no cases of conversion), in 3 patients open surgery is done. 4 patients were operated on for abdominal chronic pain, among them in three cases laparoscopy was performed, in one case open adhesiolysis was done. In order to prevent adhesions antiadhesive seprafilm membrane was applied in all patients. During laparoscopy the following technique was used - rolling of the film seprafilm with protective paper wrapper, the introduction into the abdominal cavity, the deployment of the roll, application of film to the anterior abdominal wall and the surfaces of omentum or intestines. No intra- and postoperative complications were observed. During observation no evidence of intestinal obstruction was observed in the operated patients. There was no mortality. The combination of laparoscopic adhesiolysis with antiadhesive barrier seprafilm is one of the best methods of treatment and prevention of adhesive disease of abdomen.
Low Pressure Storage of Natural Gas for Vehicular Applications (2000)

&lt;div class="htmlview paragraph"&gt;Natural gas is an attractive fuel for vehicles because it is a relatively clean-burning fuel compared with gasoline. Moreover, methane can be stored in the physically adsorbed state [at a pressure of 3.5 MPa (500 psi)] at energy densities comparable to methane compressed at 24.8 MPa (3600 psi). Here we report the development of natural gas storage monoliths [&lt;span class="xref"&gt;1&lt;/span&gt;]. The monolith manufacture and activation methods are reported along with pore structure characterization data. The storage capacities of these monoliths are measured gravimetrically at a pressure of 3.5 MPa (500 psi) and ambient temperature, and storage capacities of &amp;gt;150 V/V have been demonstrated and are reported.&lt;/div&gt;
Adaptive MMSE Turbo equalization usign high order modulation : experimental results on underwater acoustic channel (2011)

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Abstract 17094: “Trojan Horse” Monocytes: a New Approach for Gene Delivery to Angioplastied Arteries (2011)

Introduction: Monocyte-derived macrophages are implicated in sustained inflammation typical of atherosclerotic and restenotic arteries. Since the role of macrophage-mediated inflammatory reactions in the progression of atherosclerosis and post-angioplasty restenosis is firmly established, multiple approaches have been devised to decrease the number and/or functionality of mononuclear phagocytic cells residing in atherosclerotic and stented arteries. However, no prior research has exploited the capability of monocytes to target sites of vascular injury in order to introduce pro-healing “therapeutic” genes into diseased vasculature. Here we report preliminary results demonstrating feasibility of this concept. Methods and Results: Monocytes were isolated from heparinized rat blood by sequential Ficoll and Percoll gradient centrifugation. The cells labeled with CM-DiI dye (5x10 5 cells/ml) were suspended in complete RPMI1640 medium and administered via tail vein to rats that underwent balloon denudation injury of carotid arteries 4 days prior to cell therapy. The animals were euthanized on day 8 after balloon injury (day 4 after monocyte delivery). The CM-DiI-labeled cells were found in the nascent neointima and adventitia of balloon-injured arteries (373±90 and 77±37 per mm 2 of tissue, respectively). Comparison of CM-DiI labeling with immunohistochemical staining results (CD 68) has demonstrated that up to 30% of all macrophages in the neointimal tissue of rats treated with ex vivo modified monocytes derive from the delivered cells. To verify functional competence of delivered cells, monocytes isolated as above were transduced with adenovectors driving synthesis of firefly luciferase and administered to rats that underwent Fogarty balloon injury 4 days prior to the cell delivery. One day later, luciferase expression in balloon injured arteries was confirmed by bioluminescence imaging. Conclusions: These pilot studies demonstrate the feasibility of using ex vivo transfected autologous or syngeneic monocytes as a means to introduce prohealing factors to diseased vasculature.
H-CONTACT UNIT TANGENT SPHERE BUNDLES OF FOUR-DIMENSIONAL RIEMANNIAN MANIFOLDS (2011)

Abstract We study the geometric properties of a base manifold whose unit tangent sphere bundle, equipped with the standard contact metric structure, is H -contact. We prove that a necessary and sufficient condition for the unit tangent sphere bundle of a four-dimensional Riemannian manifold to be H -contact is that the base manifold is 2-stein.
Analytical Study of Inductor Simulation Circuits (1989)

This article has no abstract.
A block based encoding algorithm for matching pursuit image coding (2009)

A new encoding algorithm is proposed for encoding matching pursuit parameters in image compression applications. The new algorithm is a block based coding approach that takes advantage of correlations in atom positions and inner product coefficients in a rate distortion optimal manner. Simulation results show the proposed algorithm significantly improves the performance of the existing encoding algorithms and outperforms JPEG2000 at low bit rates.
A Network Gene-Based Framework for Detecting Advanced Persistent Threats (2014)

Advanced Persistent Threat (APT) poses a serious threat to cyber security, and its unique high unpredictability, deep concealment and grave harmfulness make the traditional network monitoring technology facing unprecedented challenges in the background of massive and complicated network traffic. This paper aimed for the urgent demand of APT network monitoring. Relying on the rapid development of big data analysis and cloud computing technology, to draw lessons from biology gene concept, we put forward a new connotation of the network gene to depict the semantic-rich behavior characteristics pattern of network applications. Through the organic combination of network protocol reverse analysis and the network data stream processing technology, we established a set of basic theories and technical architecture of network gene construction and calculation, forming a new detection framework for APTs to support the construction of intrusion-tolerant network ecological environment.
Riluzole, a Novel Neuroprotective Agent, Attenuates Both Neurologic Motor and Cognitive Dysfunction Following Experimental Brain Injury in the Rat (1996)

Several potential mechanisms are involved in mediating the pathophysiology of traumatic brain injury (TBI), including inflammatory processes and excitotoxicity. In the present study, we evaluated the ability of the use-dependent sodium channel inhibitor Riluzole to attenuate cognitive and neurologic motor deficits and reduce regional cerebral edema and histologic cell damage following lateral fluid-percussion (FP) brain injury in rats (n = 109). In study 1, 58 anesthetized male Sprague-Dawley rats (350-400 g) were subjected to FP brain injury of moderate severity (2.3-2.5 atm). Fifteen minutes following brain injury, animals randomly received an i.v. bolus of either Riluzole (4 mg/kg, n = 11), Riluzole (8 mg/kg, n = 11), or glycol vehicle (n = 20), followed by 6 h and 24 h s.c. injections (identical dose). Surgically prepared but uninjured animals received vehicle (n = 16) and served as controls. Animals were evaluated for cognitive deficits at 48 h postinjury and killed for assessment of regional brain edema. Administration of vehicle or Riluzole (4 mg/kg x 3) had no significant effect on memory or edema, whereas Riluzole (8 mg/kg x 3) significantly attenuated post-traumatic cognitive dysfunction (p < 0.05). In study 2, a second group of animals (n = 25) was injured, treated with Riluzole (8 mg/kg x 3 doses, n = 13) or vehicle (n = 12), and evaluated for neurologic motor function over 2 weeks. Animals treated with Riluzole demonstrated significantly improved motor scores beginning 1 week postinjury (p < 0.05). In study 3, brain-injured animals were treated with Riluzole (8 mg/kg x 3 doses, n = 10) or vehicle (n = 10), and posttraumatic lesion volume was assessed at 48 h postinjury using 2,3,5-triphenyltetrazolium chloride (TTC) staining. Treatment with Riluzole had no significant effect on posttraumatic lesion volume. The present study demonstrates that use-dependent sodium channel inhibitors, such as Riluzole, can attenuate both cognitive and neuromotor dysfunction associated with brain trauma.
Genaro Arriagada, Pinochet: The Politics of Power, Thematic Studies in Latin America (Boston, 1988), pp. xi+196, £8.95. (1989)

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A closed-form approximation of the outage probability for distributed MIMO systems (2009)

The instantaneous capacity of multiple-input multiple-output (MIMO) systems over Rayleigh fading channel is known to follow a normal probability distribution when the number of transmit and receive antennas is large. In this paper, we extend this result for distributed MIMO (DMIMO) systems by deriving a closed-form approximation of the outage probability which becomes tighter as the rate or the number of nodes and antennas of the system increases. This expression can be used to easily evaluate the outage probability of DMIMO systems, both for downlink and uplink cases. We also utilize this expression to compare the theoretical throughput performance of MIMO and DMIMO systems and show that DMIMO systems can achieve a throughput gain over their MIMO counterparts by taking advantage of spatial diversity.
Genome Sequence of Corynebacterium glutamicum ATCC 14067, Which Provides Insight into Amino Acid Biosynthesis in Coryneform Bacteria (2012)

We report the genome sequence of Corynebacterium glutamicum ATCC 14067 (once named Brevibacterium flavum), which is useful for taxonomy research and further molecular breeding in amino acid production. Preliminary comparison with those of the reported coryneform strains revealed some notable differences that might be related to the difficulties in molecular manipulation.
Supplementary data from Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus (2023)

&lt;p&gt;Supplementary material and methods Supplementary Table 1: miR124, miR125 and miR134 expression relative to human or mouse U6 snRNA in normal mouse CNS tissues, mouse neural stem cells, in vitro-differentiated mouse brain cells, mouse neuroblastoma, human neuroblastoma and in human glioblastoma cell culture (HGCC) lines. Supplementary Table 2: Comprehensive information of HGCC lines used in the experiments Supplementary Figure S1. SFV4-GFPmiRT and A7/74-GFPmiRT are inhibited in the presence of exogenous miR124, miR125 or miR134. Supplementary Figure S2. SFV infection induces killing of human neuroblastoma cell lines. Supplementary Figure S3. Oncolytic efficiency of A7/74miRT in murine tumor models in vitro and in vivo. Supplementary Figure S4. SFV4miRT-mediated killing of HGCC lines in vitro in the presence and absence of IFN-ÃŽÂ².&lt;/p&gt;
Autoantibodies in Primary Sjögren's Syndrome: New Insights into Mechanisms of Autoantibody Diversification and Disease Pathogenesis (2001)

Characterisation of autoantibodies and their target autoantigens in primary Sjögren's syndrome (SS) is an important entry point for studying this common systemic autoimmune disease. Diversification of anti-Ro/La responses is believed to occur by a process of determinant spreading following initiation of an autoimmune response to one component, possibly 52-kD Ro (Ro52). Recent evidence supports the ER-resident chaperone Grp78 as a potential candidate in the initiation of an autoimmune response against Ro52, by binding to a Grp78 binding motif in the COOH-terminal region of Ro52. The subsequent diversification of the anti-Ro/La response is influenced by distinct HLA class II alleles. Anti-salivary duct autoantibodies have been revisited and shown to be mimicked by cross-reactive isoantibodies to AB blood group antigens. Identification of autoantibodies that act as antagonists at M3-muscarinic receptors represents an important advance. As well as contributing to the sicca symptoms, the functional effects of these autoantibodies may explain associated features of autonomic dysfunction in patients with SS. Anti-M3 receptor autoantibodies occur in both primary and secondary SS and allow Sjögren's syndrome to be viewed as a disorder of anti-receptor autoimmunity.
Computer Simulation of Turbocharged Diesel Engines Under Transient Conditions (1987)

&lt;div class="htmlview paragraph"&gt;A computer program has been developed to simulate the operational behavior of turbocharged Diesel engines under transient conditions. The essential characteristics of this program which is based upon the filling and emptying model are presented. In particular, the code considers the waste gate behavior, the charge-air cooler and the component temperatures which vary during acceleration. A comparison between computed and measured response has been made for a turbocharged inter-cooled 4-cylinder swirl chamber Diesel engine. The code has also been used to assess improvements in the acceleration behavior which can be realized by a strongly reduced mass of inertia of the turbocharger rotors, lower friction of the bearings, variable geometry of the turbocharger turbine and heat insulation of the exhaust ports and the exhaust manifold.&lt;/div&gt;
Femtosecond parabolic pulse shaping in normally dispersive optical fibers (2013)

Formation of parabolic pulses at femtosecond time scale by means of passive nonlinear reshaping in normally dispersive optical fibers is analyzed. Two approaches are examined and compared: the parabolic waveform formation in transient propagation regime and parabolic waveform formation in the steady-state propagation regime. It is found that both approaches could produce parabolic pulses as short as few hundred femtoseconds applying commercially available fibers, specially designed all-normal dispersion photonic crystal fiber and modern femtosecond lasers for pumping. The ranges of parameters providing parabolic pulse formation at the femtosecond time scale are found depending on the initial pulse duration, chirp and energy. Applicability of different fibers for femtosecond pulse shaping is analyzed. Recommendation for shortest parabolic pulse formation is made based on the analysis presented.
R1 and R2 retrotransposable elements of Drosophila evolve at rates similar to those of nuclear genes. (1995)

Abstract The non-long-terminal repeat retrotransposable elements, R1 and R2, insert at unique locations in the 28S ribosomal RNA genes of insects. Based on the nucleotide sequences of these elements in the eight members of the melanogaster species subgroup of the genus Drosophila, they have been maintained by vertical germline transmission for the 17-20 million year history of this subgroup. The stable inheritance of R1 and R2 within these species has enabled a determination of their nucleotide substitution rates. The sequence of the R1 and R2 elements from D. ambigua, a member of the obscura species group, has also been determined to enable an extrapolation of this rate over an estimated 45-60 million years. The mean rate of substitutions at synonymous sites (Ks) was 6.6 and 9.6 times the rate at replacement sites (Ka) in the R1 and R2 elements, respectively. Both elements appear to have been under selective pressure to maintain their open reading frames and thus their ability to retrotranspose for most of their evolution in these lineages. Using the rate of change at synonymous sites (Ks) as the best indicator of the nucleotide substitution rate, the mean Ks values for R1 and R2 were 2.3 and 2.2 times that of the alcohol dehydrogenase (Adh) genes. However, this faster rate is a result of the lower codon usage bias of R1 and R2 compared with that of Adh. When the Ks rates of R1 and R2 were compared with that of a larger number of nuclear genes available from at least two of the nine species under investigation, R1 and R2 were found to evolve in most lineages at rates similar to that of nuclear genes with low codon bias. The ability of R1 and R2 to maintain their presence in this species subgroup by retrotransposition while exhibiting rates of nucleotide evolution similar to nuclear genes suggests these transposition events are rare or not as error prone as that of retroviruses.
Inhibition by viomycin of cell-free protein synthesis in sensitive and resistant strains of Rhizobium meliloti (1969)

Viomycin at a concentration of 2–10 μg/ml inhibited cell-free polypeptide synthesis in both a viomycin-sensitive and a viomycin-resistant strain of Rhizobium meliloti when either natural messenger or polyuridylic acid (poly U) was employed. Consequently, viomycin resistance in the resistant bacterium is not the result of an inherently resistant protein-synthesizing system or of an intracellular modification of the viomycin molecule. The antibiotic did not prevent the formation of active poly U – ribosome complexes, but did inhibit the passage of 14 C from 14 C-phenylalanine-charged transfer RNA to these complexes.
An innovative beamsplitter-based stereoscopic/3D display design (2005)

A novel stereoscopic/3D desktop monitor has been developed that combines the output of two active matrix LCDs (AMLCDs) into a stereo image through use of a unique beamsplitter design. This approach, called the StereoMirror, creates a stereo/3D monitor that retains the full resolution, response time and chromaticity of the component displays. The resultant flicker-free image, when viewed with passive polarizing glasses, provides an unprecedented level of viewing comfort in stereo. The monitor also is bright enough to use in normal office lighting. The display has excellent optical isolation of the two stereo channels and a wide viewing angle suitable for multi-viewer use. This paper describes the architecture of the system and the principal of conservation of polarization that results in the full-definition stereo image. Optical performance results are also described. Practical considerations will be discussed, including system interface requirements, conversion between stereo/3D and monoscopic viewing and comparison to other stereo display approaches. The higher level of performance provided by the StereoMirror allows for stereo viewing to be viable in new imaging markets as well as permitting a more effective use of stereo in existing markets. These applications are discussed.
CYP1A1 Regulates Breast Cancer Proliferation and Survival (2013)

Cytochrome P450-1A1 (CYP1A1) is an extrahepatic phase I metabolizing enzyme whose expression is suppressed under physiologic conditions but can be induced by substrates via the aryl hydrocarbon receptor (AhR). Recent studies have shown that the majority of breast cancer tumors constitutively express CYP1A1. These findings led us to test the hypothesis that CYP1A1 promotes breast cancer progression by evaluating the effects of CYP1A1 knockdown on the proliferation and survival of the MCF7 and MDA-MB-231 lines. Independently of estrogen receptor status, CYP1A1 knockdown decreased colony formation, decreased cell proliferation, blocked the cell cycle at G0-G1 associated with reduction of cyclin D1, and increased apoptosis associated with reduction of survivin. CYP1A1 knockdown markedly increased phosphorylation of AMP-activated protein kinase (AMPK) and decreased phosphorylation of AKT, extracellular signal-regulated kinases 1 and 2 (ERK1/2), and 70-kDa ribosomal protein S6 kinase (P70S6K). AMPK inhibition by compound C partially abrogated the proapoptotic effects of CYP1A1 knockdown, suggesting that effects of CYP1A1 knockdown are mediated in part through AMPK signaling. Consistent with CYP1A1 knockdown, pharmacologic reduction of CYP1A1 levels by the phytopolyphenol carnosol also correlated with impaired proliferation and induced AMPK phosphorylation. These results indicate that reduction of basal CYP1A1 expression is critical for inhibition of proliferation, which is not affected by α-naphthoflavone-mediated inhibition of CYP1A1 activity nor modulated by AhR silencing. This study supports the notion that CYP1A1 promotes breast cancer proliferation and survival, at least in part, through suppression of AMPK signaling and that reduction of CYP1A1 levels is a potential strategy for breast cancer therapeutics.