gebhart/patrepeval huggingface dataset:
Proceedings of the 7th workshop on Workshop on languages, compilers, and run-time support for scalable systems (2004)

The Workshop on Languages, Compilers, and Run-time Support for Scalable Systems (LCR) is a bi-annual gathering of computer scientists who develop enabling software for large scale parallel and distributed applications, held in the off-year for PPoPP. Attendance for this workshop is limited to 75 participants. The LCR community is interested in a broad range of technologies, with a common goal of developing systems that enable real applications.Scalability is important for scientific as well as commercial applications, and has to be addressed across computation models spanning data parallel computing, grid computing, peer-to-peer computing, content distribution networks, and multi-threaded servers. For this seventh meeting, LCR 04, we are especially interested in cross-fertilization of ideas in supporting and enhancing scalability across this spectrum of applications and computation models. Topics of interest to the workshop include the following:•Emerging applications•Language features and compilation•Communication systems and libraries•Resource management•Integration of compiler and runtime systems•Scalable I/O•Performance evaluation•Debuggers•Fault tolerance and reliability•Operating Systems
Understanding Everyday Hands in Action from RGB-D Images (2015)

We analyze functional manipulations of handheld objects, formalizing the problem as one of fine-grained grasp classification. To do so, we make use of a recently developed fine-grained taxonomy of human-object grasps. We introduce a large dataset of 12000 RGB-D images covering 71 everyday grasps in natural interactions. Our dataset is different from past work (typically addressed from a robotics perspective) in terms of its scale, diversity, and combination of RGB and depth data. From a computer-vision perspective, our dataset allows for exploration of contact and force prediction (crucial concepts in functional grasp analysis) from perceptual cues. We present extensive experimental results with state-of-the-art baselines, illustrating the role of segmentation, object context, and 3D-understanding in functional grasp analysis. We demonstrate a near 2X improvement over prior work and a naive deep baseline, while pointing out important directions for improvement.
Predicting Merge Conflicts in Collaborative Software Development (2019)

Background. During collaborative software development, developers often use branches to add features or fix bugs. When merging changes from two branches, conflicts may occur if the changes are inconsistent. Developers need to resolve these conflicts before completing the merge, which is an error-prone and time-consuming process. Early detection of merge conflicts, which warns developers about resolving conflicts before they become large and complicated, is among the ways of dealing with this problem. Existing techniques do this by continuously pulling and merging all combinations of branches in the background to notify developers as soon as a conflict occurs, which is a computationally expensive process. One potential way for reducing this cost is to use a machine-learning based conflict predictor that filters out the merge scenarios that are not likely to have conflicts, i.e.safe merge scenarios.Aims. In this paper, we assess if conflict prediction is feasible.Method. We design a classifier for predicting merge conflicts, based on 9 light-weight Git feature sets. To evaluate our predictor, we perform a large-scale study on 267,657 merge scenarios from 744 GitHub repositories in seven programming languages.Results. Our results show that we achieve high f1-scores, varying from 0.95 to 0.97 for different programming languages, when predicting safe merge scenarios. The f1-score is between 0.57 and 0.68 for the conflicting merge scenarios.Conclusions. Predicting merge conflicts is feasible in practice, especially in the context of predicting safe merge scenarios as a pre-filtering step for speculative merging.
Molecular cloning and expression of an .ALPHA.-amylase gene from an .ALPHA.-amylase extrahyper producing Bacillus subtilis. (1988)

Bacillus subtilis 2633 hyperproduced α-amylase (about 3000-fold amount of the parental strain, B. subtilis 6160). An α-amylase gene of B. subtilis 2633 was cloned into Escherichia coli using a B. subtilis-E. coli shuttle vector, pHY300PLK. When the recombinant plasmid pAM26 containing the α-amylase gene was introduced into B. subtilis 6160, a transformant produced about 40, 000 U/ml of α-amylase, which is 4000 times that of B. subtilis 6160. This indicates that the α-amylase gene (amyR-amyE) of 2633 has hyperproducing activity in itself. The nucleotide sequencing of the promotor region and comparison with those of other B. subtilis strains suggested that several differences in the nucleotide sequences upstream from the transcription initiation site could be responsible for the α-amylase production. Southern blot analysis showed that B. subtilis 2633 contains several copies of the α-amylase gene, which should also contribute to the hyperproductivity.
Observation on Tidal Current Structure and Ship Movement within the Kurushima Channel Traffic Route (1999)

Authors surveyed and analyzed tidal current flows and structures by 300KHz ADCP and observed on ship movement by Data Recording System of T.S. Yuge-Maru (240tons) at the passage area of the Kurushima channel on August 26 and 27, 1997. Results are summarized as follows; (1) Remarkable changes in tidal flows were observed near Osumi Headland, Tsushima Island, Oshima Island, which can be regarded as the effect of island and headlands. (2) The upper layer flows of tidal current were almost similar to the lower layer flows except at several deep areas. (3) Effects of the tidal current for ship movement were controlled by the upper layer flows.
Demonstration of enhanced performance of an InP/InGaAs heterojunction phototransistor with a base terminal (1991)

The optical gain and the small-signal frequency response of an InP/InGaAs heterojunction phototransistor (HPT) with a base terminal are investigated in detail for the first time. When operated under an optimally chosen external base current, the optical gain is enhanced more than five times over that of the same device operated as a two-terminal device, over a 17-dB range of input optical power. The small-signal 3-dB bandwidth of the three-terminal device is enhanced 15 times over that of the two-terminal device over the same range of input optical power. For a pseudorandom NRZ bit stream at 100 Mb/s, a clear eye opening is observed at an incident optical power of -33 dBm (500 nW).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Facilitation of Thin-Layer Chromatographic Identification of Opiates by Derivatization with Acetic Anhydride or Methoxyamine (1995)

Qualitative identification of opiates in urine is commonly achieved in two stages, the first involving immunoassay screening and the second involving chromatographic confirmation. Identification of specific opiates is often requested to determine whether the source of opiates is from diet, prescription pharmaceuticals, or illicit drugs. During evaluation of the Toxi-Lab thin-layer chromatographic system as a confirmatory technique for urinary opiates, we encountered difficulty distinguishing opiates with similar retention factor values and colorimetric behavior. By exploiting chemical differences of the comigrating opiates through preparation of acetate or methoxime derivatives, followed by chromatography of the underivatized and derivatized samples in adjacent lanes, we were able to more easily distinguish codeine from hydrocodone, 6-acetylmorphine from oxymorphone, and dihydrocodeine from hydromorphone.
Dynamics of rectal balloon implant shrinkage in prostate VMAT (2017)

Despite significant decrease in RBI volume the high-dose rectal volume and the predicted LRB risk were unaffected due to a persistent spacing between the prostate and the anterior rectal wall.
Cover Image (2019)

The cover image is based on the Original Article * Association of CD204+ macrophages with poor outcomes of malignant lymphomas not in remission treated by allogeneic HCT by Shigehisa Kitano** et al., https://doi.org/10.1111/ejh.13324.***
The Role of Massive Transfusion Protocols in Obstetrics (2012)

Obstetric hemorrhage is a leading cause of maternal mortality worldwide. New concepts involving the pathophysiology of hemorrhage have been described and include early activation of both the protein C and fibrinolytic pathways. New tendencies in hemorrhage treatment include the use of hemostatic resuscitation. Massive transfusion protocols involve the early utilization of blood products and limit the traditional approach of early massive crystalloid based resuscitation. The evidence behind hemostatic resuscitation is still limited.
Proton Pump Inhibitors Accelerate Endothelial Senescence (2016)

Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.
Development of the Imaging Plate for the Transmission Electron Microscope and Its Characteristics (1990)

The new Imaging Plate (IP) and the new IP-reader whose sampling pixel size is 50 μm are developed for the transmission electron microscope (TEM). The structure of the new IP and the optical configuration of the new IP-reader are described. Effective area of the IP is 77 × 102 mm. This system has sensitivity higher than 10−14 C/cm2, its dynamic range for an image is 4 decades and data have 4096 gray levels. As for the resolution, response of the IP to the electrons is studied as a function of spatial frequency. The dependence of sensitivity on accelerating voltage is also measured.
Control of oxidative phosphorylation during insect metamorphosis (2004)

The midgut of the tobacco hornworm (Manduca sexta) is a highly aerobic tissue that is destroyed and replaced by a pupal epithelium at metamorphosis. To determine how oxidative phosphorylation is altered during the programmed death of the larval cells, top-down control analysis was performed on mitochondria isolated from the midguts of larvae before and after the commitment to pupation. Oxygen consumption and protonmotive force (measured as membrane potential in the presence of nigericin) were monitored to determine the kinetic responses of the substrate oxidation system, proton leak, and phosphorylation system to changes in the membrane potential. Mitochondria from precommitment larvae have higher respiration rates than those from postcommitment larvae. State 4 respiration is controlled by the proton leak and the substrate oxidation system. In state 3, the substrate oxidation system exerted 90% of the control over respiration, and this high level of control did not change with development. Elasticity analysis, however, revealed that, after commitment, the activity of the substrate oxidation system falls. This decline may be due, in part, to a loss of cytochrome c from the mitochondria. There are no differences in the kinetics of the phosphorylation system, indicating that neither the F(1)F(0) ATP synthase nor the adenine nucleotide translocase is affected in the early stages of metamorphosis. An increase in proton conductance was observed in mitochondria isolated from postcommitment larvae, indicating that membrane area, lipid composition, or proton-conducting proteins may be altered during the early stages of the programmed cell death of the larval epithelium.
Territory restriction: The European Commission founds unlawful a gas transit agreement limiting resale beyond point of delivery (GDF/ENI) (2004)

La Commission condamne sans sanctionner une clause du contrat de transit interdisant la vente en amont du point du livraison EC Comm., 26 October 2004, GDF/ENI, case COMP/38.662 Depuis la fin…
Galactosyltransferase Activities In Ehrlich Ascites Tumor Cells. (1986)

Oligosaccharides covalently bound to Synsorb beads (Chembiomed Ltd., Alberta, Canada) have been utilized as probes for the detection, purification, and characterization of glycosyltransferases in Ehrlich ascites tumor cells. Appropriate conditions have been developed to assay for transferase activities by determining the incorporation of radioactive sugars into the oligosaccharide-Synsorb beads. The nature of the anomeric linkage formed in the enzymatic reaction was assessed by digestion with various exoglycosidases. Additionally, a permethylation procedure has been devised to investigate the intersugar linkage generated upon incubation of ('14)C -(beta)-D-Gal-(1,4)-(beta)-D-GlcNAc-Synsorb beads with UDP-Gal, or UDP-GlcNAc, in the presence of microsomal extracts of Ehrlich tumor cells. In this fashion, Ehrlich cells have been shown to contain an (alpha)(1,3)-galactosyltransferase and a (beta)(1,3)-N-acetylglucosaminyltransferase which may be responsible for the presence of (alpha)-D-galactosyl-terminated poly-N-acetyllactosaminoglycan structures on the plasma membrane of Ehrlich cells. A separate (beta)-N-acetylglucosaminyltransferase activity which utilized (beta)-D-GlcNAc(1,3)-(beta)-D-Gal-(1,4)-(beta)-D-GlcNAc-Synsorb as acceptor was found in Ehrlich cell microsomes, and was postulated to initiate the synthesis of blood group I antigenic structures. A (beta)-D-Gal-(1,4)-D-GlcNAc (alpha)(1,3)-galactosyltransferase and a GlcNAc (beta)(1,4)-galactosyltransferase have been purified 205,000- and 17,560-fold, respectively, to apparent homogeneity from Lubrol PX extracts of Ehrlich tumor cell microsomal membranes. The two transferases were separated from contaminating proteins by affinity chromatography on (alpha)-lactalbumin-Sepharose and (beta)GlcNAc-Synsorb, and purified by adsorption to UDP-hexanolamine-Sepharose. The subunit molecular weights of the (alpha)- and (beta)-galactosyltransferases were 80,000 and 56,000, respectively. Both enzymes required manganese and detergent for catalytic activity. N-Acetyllactosamine and a variety of glycoconjugates terminated in this disaccharide all served as acceptors for the Ehrlich cell (alpha)-galactosyltransferase. (alpha)-Lactalbumin modified the acceptor specificity of the Ehrlich tumor cell (beta)-galactosyltransferase by decreasing the Michaelis constant for glucose with a concomitant increase in the K(,m) for N-acetylglucosamine. Molecules of Glc and GlcNAc that had been substituted at various positions of the pyranose ring were tested for their ability to serve as acceptors for the Ehrlich cell (beta)-galactosyltransferase, both in the presence and in the absence of (alpha)-lactalbumin. This study allowed a determination of the molecular contacts between the (beta)-galactosyltransferase and its acceptor substrate necessary for enzymatic activity.
Drosophila SMN2 minigene reporter model identifies moxifloxacin as a candidate therapy for SMA (2019)

Spinal muscular atrophy is a rare and fatal neuromuscular disorder caused by the loss of alpha motor neurons. The affected individuals have mutated the ubiquitously expressed SMN1 gene resulting in the loss or reduction in the survival motor neuron (SMN) protein levels. However, an almost identical paralog exists in humans: SMN2. Pharmacological activation of SMN2 exon 7 inclusion by small molecules or modified antisense oligonucleotides is a valid approach to treat SMA. Here we describe an in vivo SMN2 minigene reporter system in Drosophila motor neurons that serves as a cost-effective, feasible, and stringent primary screening model for identifying chemicals capable of crossing the conserved Drosophila blood-brain barrier and modulating exon 7 inclusion. The model was used for the screening of 1100 drugs from the Prestwick Chemical Library, resulting in 2.45% hit rate. The most promising candidate drugs were validated in patient-derived fibroblasts where they proved to increase SMN protein levels. Among them, moxifloxacin modulated SMN2 splicing by promoting exon 7 inclusion. The recovery of SMN protein levels was confirmed by increased colocalization of nuclear gems with Cajal Bodies. Thus, a Drosophila-based drug screen allowed the discovery of an FDA-approved small molecule with the potential to become a novel therapy for SMA.
Tantalum nitride as a diffusion barrier between Pd2Si or CoSi2 and aluminum (1989)

Reactively sputtered tantalum nitride (Ta2N) has been investigated as a diffusion barrier between Pd2Si and aluminum and CoSi2 and Al. Ta2N is found to be an excellent matallurgical diffusion barrier for the two systems up to 555 °C, with no intermixing observed in Rutherford backscattering and Auger electron spectroscopic studies. Schottky barrier devices n-Si/Pd2Si/Ta2N/Al were excellent and showed no deterioration after annealing at 500 °C. However, similar devices with CoSi2 contacts and Ta2N barrier showed a creation of high contact resistance between the silicide and the as-deposited nitride.
Carboxyhemoglobin as measured by gas chromatography and with the IL 282 and 482 CO-Oximeters. (1988)

We measured the concentration of carboxyhemoglobin (HbCO) in original and CO-tonometered blood samples from 53 intensive-care patients with IL 282 and IL 482 CO-Oximeters and by gas chromatography (GC), finding very strong correlations among the three methods for HbCO concentrations greater than 2.5%. For concentrations within the normal reference interval (less than or equal to 2.5%), however, the correlation between CO-Oximetry and GC is poor (r2 less than 0.26). The capillary mode of the IL 482 has a consistently lower correlation with any other method or mode. The correlations of measurements between the CO-Oximeters for total hemoglobin and oxyhemoglobin were excellent (r2 greater than or equal to 0.98). Correlations for methemoglobin were lower, owing to its low concentrations in the samples. We conclude that the IL 482 and the IL 282 are analytically equivalent for all analytes measured, but that both instruments differentiate poorly between HbCO values that fall within the reference interval.
ChemInform Abstract: Novel Concepts in Direct Biaryl Synthesis. Part 60. 1,3‐Di‐tert‐butyl‐ 6H‐benzo(b)naphtho(1,2‐d)pyran‐6‐thione, a Severely Helically Distorted Thionolactone‐Bridged Biaryl. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling IP-ATM gateway using M/G/1/N queue (2002)

Because of the growing investment in both IP and ATM networks, designing efficient IP-ATM gateways for interconnecting these two networks has become very important. One of the main design issues is buffer dimensioning at the gateway for optimum performance. Modeling IP-ATM gateways helps obtaining the optimum design. However, due to very complex nature of an IP-ATM gateway, only models for gateways with infinite buffers have been studied previously. In this paper, an M/G/1/N model for studying the performance of IP-ATM gateway with finite buffers is presented. The performance of the IP-ATM gateway as a function of the buffer size is studied through analysis of the proposed model. The accuracy of the proposed model is verified through simulation.
Influence of stress state on plastic flow and ductile fracture of three 6000-series aluminium alloys (2020)

In this study, the plastic flow and ductile fracture of three 6000-series aluminium alloys commonly used for crash components in the automotive industry are characterised experimentally and the observations are related to microstructural features. The three alloys are used in the cast and homogenised condition after artificial ageing to temper T6 to ensure isotropic behaviour. Tension tests on smooth and notched axisymmetric specimens are carried out to reveal the stress–strain behaviour, ductility and fracture mechanisms of the materials for different stress states. Through the use of optical and scanning electron microscopes, the initial microstructure of the alloys and the fracture surfaces of the tension test specimens are investigated. The work-hardening of the alloys is analysed up to large strains. Whereas the ductility of two of the alloys falls into the trend of previous experimental data on 6000-series aluminium alloys, where the strain to failure decreases linearly with increasing yield stress, the third alloy stands out by combining high strength with high ductility. The excellent properties of the latter alloy are assumed to be due to a favourable size distribution of constituent particles.
Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression (2017)

Despite progress in diagnosis and treatment of hepatocellular carcinoma (HCC), the clinical outcome is still unsatisfactory. Increased expression of human growth hormone (hGH) in HCC has been reported and is associated with poor survival outcome in HCC patients. Herein, we investigated the mechanism of the oncogenic effects of hGH in HCC cell lines. In vitro functional assays demonstrated that forced expression of hGH in these HCC cell lines promoted cell proliferation, cell survival, anchorage-independent growth, cell migration, and invasion, as previously reported. In addition, forced expression of hGH promoted cancer stem cell (CSC)-like properties of HCC cells. The increased invasive and CSC-like properties of HCC cells with forced expression of hGH were mediated by inhibition of the expression of the tight junction component CLAUDIN-1. Consistently, depletion of CLAUDIN-1 expression increased the invasive and CSC-like properties of HCC cell lines. Moreover, forced expression of CLAUDIN-1 abrogated the acquired invasive and CSC-like properties of HCC cell lines with forced expression of hGH. We further demonstrated that forced expression of hGH inhibited CLAUDIN-1 expression in HCC cell lines via signal transducer and activator of transcription 3 (STAT3) mediated inhibition of CLAUDIN-1 transcription. Hence, we have elucidated a novel hGH-STAT3-CLAUDIN-1 axis responsible for invasive and CSC-like properties in HCC. Inhibition of hGH should be considered as a therapeutic option to hinder progression and relapse of HCC.
The feasibility of using V.A.C.® Therapy in home care patients with surgical and traumatic wounds in the Netherlands (2008)

Abstract The aim of this study was to review the feasibility of using vacuum‐assisted closure (V.A.C. ® ) Therapy for the management of surgical and traumatic wounds in the home care settings in the Netherlands. De‐identified patient data were collected from a health insurance database in the Netherlands. All patients with complete records, including indication, age, duration of therapy and defined treatment goal between January and November 2006 were included. Data from 338 patients were analysed. On average, wounds had been present for 2 months before start of V.A.C. Therapy. Overall, 74% of patients reached the pre‐defined therapy goal (77% for dehisced wounds, 68% for abdominal wounds, 73% for traumatic wounds and 91% for sternal wounds) with approximately 1 month of V.A.C. Therapy. There was a negative association between the wound duration prior to V.A.C. Therapy and the treatment success rate ( r = −0·162, P = 0·003). Wounds with shorter duration (≤4 weeks) prior to initiation of V.A.C. Therapy achieved an 82% success rate compared with 33% for wounds present for &gt;6 months prior to V.A.C. Therapy. V.A.C. Therapy is a feasible and effective treatment for surgical and traumatic wounds in home care patients with over 70% of patients treated in this sample achieving pre‐defined treatment goals. The success rate of V.A.C. Therapy is negatively associated with the duration of the wound before V.A.C. Therapy is commenced.