gebhart/patrepeval huggingface dataset:
It's not a Sprint, it's a Marathon (2019)

During the past few years, all leading cloud providers introduced burstable instances that can sprint their performance for a limited period to address sudden workload variations. Despite the availability of burstable instances, there is no clear understanding of how to minimize the waste of resources by regulating their burst capacity to the workload requirements. This is especially true when it comes to non-CPU-intensive applications. In this paper, we investigate how to limit network and I/O usage to optimize the efficiency of the bursting process. We also study which resource shall be controlled to benefit both cloud providers and end-users. We design MRburst (Multi-Resource burstable performance scheduler) to automatically limit multiple resources (i.e., network, I/O, and CPU) and make the application comply with a user-defined service level objective (SLO) while minimizing wasted resources. MRburst is evaluated on Amazon EC2 using two multi-resource applications: an FTP server and a Ceph system. Experimental results show that MRburst outperforms state-of-the-art approaches by allowing instances to speed up their performance for up to 2.4 times longer period while meeting SLO.
Lightweight panels with high delamination resistance made of integrally woven truss-like fabric structures (2023)

Lightweight panels are of high relevance for various applications, such as automotive, aerospace, civil engineering, and achieve high stiffnesses and strengths at low self-weight. The sandwich principle is commonly used to manufacture the panels, although conventional materials and reinforcement structures often limit the design and application of the panels in a wide range of possible applications. The reason for this is that lightweight panels fail either under combined compressive/shear loading or as a result of delamination of the individual layers. In this article, novel fabric structures are presented as a basis for the fabrication of lightweight panels that effectively overcome these deficiencies. These fabrics have a spatial truss-like structure, with the core and top layer being connected by continuously running reinforcing fibers. This results in high panel stability and high delamination resistance, which are evaluated in this article using mechanical tests in compression, flexure and combined tension-shear. The results are related to sample panels with conventional honeycomb core as reference. The high potential and excellent delamination resistance of the new fabric-based lightweight panels is shown in the result of the tests.
Supplementary Data from Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification (2023)

Supplementary Data from Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification
The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth (2015)

The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. However, the redundancy of PP1 isoforms and the lack of specific inhibitors have hampered studies on the global role of PP1 in cell cycle progression in vertebrates. Here, we show that the overexpression of nuclear inhibitor of PP1 (NIPP1; also known as PPP1R8) in HeLa cells culminated in a prometaphase arrest, associated with severe spindle-formation and chromosome-congression defects. In addition, the spindle assembly checkpoint was activated and checkpoint silencing was hampered. Eventually, most cells either died by apoptosis or formed binucleated cells. The NIPP1-induced mitotic arrest could be explained by the inhibition of PP1 that was titrated away from other mitotic PP1 interactors. Consistent with this notion, the mitotic-arrest phenotype could be rescued by the overexpression of PP1 or the inhibition of the Aurora B kinase, which acts antagonistically to PP1. Finally, we demonstrate that the overexpression of NIPP1 also hampered colony formation and tumor growth in xenograft assays in a PP1-dependent manner. Our data show that the selective inhibition of PP1 can be used to induce cancer cell death through mitotic catastrophe.
Comparative Effects of Angiotensin II AT-1-Type Receptor Antagonists In Vitro on Human Platelet Activation (2000)

A recent study has shown that losartan, an AT-1-receptor antagonist, interacts with thromboxane A2 (TxA2)/prostaglandin H2 (PGH2) receptors in human platelets. The aim of this study was to analyze the ability of different angiotensin II (Ang II) AT-1-receptor antagonists to inhibit TxA2-dependent human platelet activation. Platelets were obtained from healthy volunteers. Platelets were stimulated with the TxA2 analogue, U46619 (10(-6) M). U46619-stimulated platelet activation was significantly reduced by both losartan and irbesartan in a dose-dependent manner. Only maximal doses of valsartan (5 x 10(-6) M) and the main metabolite of losartan, EXP3174 (5 x 10(-6) M), reduced U46619-induced platelet activation. Whereas the active form of candesartan cilexetil (candesartan, CV-11974) failed to modify platelet activation involved by TxA2, telmisartan showed a higher effect than valsartan and EXP3174 but lower than either losartan and irbesartan. Losartan or irbesartan reduced the binding of [3H]-U46619 to platelets, an effect that was observed with lower ability with the other AT-1 antagonists. Although platelets expressed AT-1-type receptors, exogenous Ang II did not modify platelet activation. This effect was not modified by blocking the AT-2 receptor with PD123319. These results suggest that some AT-1-receptor antagonists reduce TxA2-dependent activation independent of Ang II involvement.
Preparation and Calcium Complexation Properties of a Series of Oxidized Polysaccharides. Structural and Conformational Effects (1985)

Abstract A number of polysaccharides of the starch type, including maltodextrins and cyclodextrins and some other well‐known polysaccharides have been oxidized by periodate/chlorite (two‐step method) or hypochlorite (one‐step method), yielding ring‐opened polycarboxylates. The oxidation products from the starch type show by far the best calcium complexing properties and have potential application as phosphate substitutes in detergent formulations. A relatively sharp increase in calcium complexing ability is observed at a degree of polymerization of about ten, whereas just a slight further improvement occurs at higher degrees of polymerization. This phenomenon is explained by the formation of helix structures which contain efficient Ca(II) complexing sites. This idea is supported by 17 O NMR measurements showing that oxidized starch type compounds with m &gt; 10 behave as heptadentate ligands.
Modeling of Compound Profiling Experiments Using Support Vector Machines (2014)

Profiling of compounds against target families has become an important approach in pharmaceutical research for the identification of hits and analysis of selectivity and promiscuity patterns. We report on modeling of profiling experiments involving 429 potential inhibitors and a panel of 24 different kinases using support vector machine (SVM) techniques and naïve Bayesian classification. The experimental matrix contained many different activity profiles. SVM predictions achieved overall high accuracy due to consistently low false-positive and consistently high true-negative rates. However, predictions for promiscuous inhibitors were affected by false-negative rates. Combined target-based SVM classifiers reached or exceeded the performance of SVM profile prediction methods and were superior to Bayesian classification. The classifiers displayed different prediction characteristics including diverse combinations of false-positive and true-negative rates. Predicted and experimentally observed compound activity profiles were compared in detail, revealing activity patterns modeled with different accuracy.
Biomechanical Response of the Pediatric Abdomen, Part 2: Injuries and Their Correlation with Engineering Parameters (2008)

This paper describes the injuries generated during dynamic belt loading to a porcine model of the 6-year-old human abdomen, and correlates injury outcomes with measurable parameters. The test fixture produced transverse, dynamic belt loading on the abdomen of 47 immediately post-mortem juvenile swine at two locations (upper/lower), with penetration magnitudes ranging from 23% - 65% of the undeformed abdominal depth, with and without muscle tensing, and over a belt penetration rate range of 2.9 m/s - 7.8 m/s. All thoracoabdominal injuries were documented in detail and then coded according to the Abbreviated Injury Scale (AIS). Observed injuries ranged from AIS 1 to AIS 4. The injury distribution matched well the pattern of injuries observed in a large sample of children exposed to seatbelt loading in the field, with most of the injuries in the lower abdomen. Univariate and multiple regression models were used to assess mechanical predictors as injury criteria for maximum AIS 2+ and 3+ outcomes, including peak belt tension and posterior reaction force, abdominal penetration, penetration rate, the viscous criterion, and a newly proposed criterion, FCmax, which is the maximum of the instantaneous product of loading rate and normalized penetration. The Goodman-Kruskal Gamma (gamma) was used to assess each parameter's ability to discriminate between injurious and non-injurious tests. Injury risk functions were generated for both outcomes by fitting a 2-parameter Weibull distribution to the injury data using survival analysis. The best discriminators were peak belt tension (gamma = 0.86 and 0.83, p < 0.01), the work done by the deforming thorax (gamma = 0.86 and 0.74, p < 0.01), and abdominal penetration (gamma = 0.89 and 0.66, p < 0.02). Penetration rate was not a good discriminator (gamma = 0.34 and 0.52), and the consideration of penetration rate decreased the discrimination of the viscous criterion (gamma = 0.67 and 0.58) relative to penetration alone. FCmax was a better discriminator of injury than the viscous criterion (gamma = 0.70 and 0.76, p < 0.01), indicating that the loading rate may be more related to injury outcome than the penetration rate.
Background for the New Design Equations for Grouted Connections in the DnV Draft Rules for Fixed Offshore Structures (1989)

ABSTRACT DnV's new Rules for Fixed Offshore Installations (draft) has replaced previous parametric formulae for the strength of grouted connection with equations based on a physical interpretation of the strength of grouted connections. The paper gives the background for the equations. It also explains the background for the safety factors adopted. The design formulae apply to pile sleeve connections, bolted clamps prestressed clamps and other related connections. INTRODUCTION DnV has recently completed the development of a new set of Rules for Fixed Offshore Installations. The new rules cover both steel and concrete structures as well as production and utility systems and equipment. It stipulates requirements for the design, construction, installation and operation. Giving ample time for overlap, it is the intention that this new code will replace DnV's "Rules for the Design and Construction of Fixed Offshore Structures"2 which was published in 1977. The development of the new code principally aims; at incorporating recent developments in various technical areas. Grouted tubular steel connections which are typically used for in situ application is such an area. The most common applications are as pile sleeve connections, as site joints and as repair clamps. Axial force is a principal load for this type of connection. Traditionally code provisions have implicitly assumed that the forces in such connections are transferred by cohesion or adhesion between the grout and the steel. Code provisions have ranged from a simple specification of a value for the permissible interface shear stress to more complex parametric formulae of empirical derivation. The bulk of test data was obtained as recently as about ten years ago. Experience of the performance of grouted connections has largely been related to applications with low interface shear stresses in earlier times. Only in recent years have we seen extensive use of grouted connections with a high utilization of their structural capacity. The present generation of design codes have therefore included appropriately high margins of safety in their provisions for design of grouted connections. The 1977 edition of DnV's "Rules" for the Design and Construction of Fixed Offshore Structures" 2 incorporated a new safety format and safety margins which had been the subject of extensive study. It is therefore the intention to maintain the same safety format in the proposed new code. From being pictured in the mind of those involved as a material used to fill the gap between the chord and the pile, grouted construction is today being used to structurally reinstate and also to seal damaged pipelines. Today?s grouted clamps which may incorporate prestressing and liners may be designed using non linear finite element analysis. Grouted construction has in the past ten years developed greatly. It is therefore also appropriate that this is properly reflected in code provisions.
Determining the rotation direction in pulsars (2019)

Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these applications. Here we show that mechanical-optical rotation in the pulsar magnetosphere affects polarisation in a way which is indiscernible from Faraday rotation in the interstellar medium for typical GHz observations frequency, but which can be distinguished in the sub-GHz band. Besides being essential to correct for possible systematic errors in interstellar magnetic field estimates, this result offers a unique means to determine the rotation direction of pulsars, providing additional constraints on magnetospheric physics. With the ongoing development of sub-GHz observation capabilities, our finding promises discoveries, such as the spatial distribution of pulsars rotation directions, which could exhibit potentially interesting, but presently invisible, correlations or features.
The Unrestricted Hartree-Fock Theory of Chemical Reactions. IV: Singlet Radical States with "Antiferromagnetic" Spin Orderings in Four-Center Exchange Reaction of Hydrogen Molecules (1975)

A UHF theoretical analysis is carried out on four-center exchange reaction of two hydrogen molecules in reaction paths with D2 symmetry including D2h, D2d and Td conformations as special cases. It is shown that the UHF singlet ground state of the H4 system consists of ten distinct UHF configurations which appear at different regions of nuclear configuration space. Three among the ten configurations are closed shell type and the other seven correspond to singlet radicals with distinct “antiferromagnetically” ordered spin structures. Three among the seven singlet radical configurations have spin structures modulated one dimensionally, the other three have those modulated two dimensionally and are very similar to Overhauser's helical spin density wave. Another configuration has tera-hedrally modulated spin structure. The adiabatic potentials of the UHF configurations are calculated and their interconnection relation is studied. The electronic correlation effects underlying these singlet radical states are discussed in connection with orbital correlation diagrams.
Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines by Employing Polymer-Supported Reagents: Preparation of DC-81 (2004)

Polymer-supported reagents have been utilized for the generation of combinatorial library of substituted pyrrolo[2,1-c][1,4]benzodiazepine derivatives that provides a clean and efficient preparation and does not require conventional purification techniques like chromatography. This methodology involves intra molecular aza-Wittig reaction and has been extended for the synthesis of the natural product DC-81 in good overall yields.
Viscosimetry using a new electromagnetic-acoustic microbalance (2008)

The nanostructure evolution of gels, biomaterials or porous media can be characterized by its mechanical properties. Few nondestructive techniques are developed to investigate the viscosity evolution. This paper present a new electromagnetic-acoustic technique using a wireless thickness shear mode transducer. A suitable model of the measurement is also presented to characterize the viscosity of the nanostructure in contact with the transducer. This transducer is a double copper-clad PVDF substrate resonator, designed to operate over a wide radiofrequency range without lumped tuning capacitors. This architecture constitutes an alternative solution to design a high-Q ultrasonic microbalance. To characterize the material at the surface of the transducer, the evolution of the induced complex impedance is measured. From this evolution, the mechanical energy storage and dissipation in the material can be extracted. In order to validate the lumped element model used, a series of glycerol/water mixtures is studied. We show that the resonant frequency shift and damping follow an accurate linear shape (&amp;lt;5%) according to the square root of the liquid viscosity and density product. This result is in good agreement with the classical prediction of Martin and Kanazawa obtained with a quartz crystal microbalance.
Key role of the pore volume of zeolite for selective production of propylene from olefins (2010)

A plausible reaction mechanism for propylene (C(3)H(6)) production from ethylene (C(2)H(4)) was investigated, based on the amounts of effluent hydrocarbons and hydrocarbons produced in the pores of SAPO-34. Propylene was produced via an oligomerization-cracking mechanism. On the basis of this mechanism, the conversions of C(2)H(4), pentenes, and hexenes were examined. The catalytic performance was compared, in order to investigate the role of the pore volume of zeolites with 8-, 10-, and 12-membered rings in the selective production of C(3)H(6). The selectivity for C(3)H(6) was crucially dependent upon the pore volume of the zeolite. Highly selective production of C(3)H(6) from olefins (C(2)H(4), pentenes, and hexenes) can be accomplished by employing a new concept: adjusting the pore volume of a zeolite to accommodate the volume of an olefin and/or its carbenium cations, as opposed to a conventional molecular sieve approach. For example, an unimolecular cracking of pentenes into C(3)H(6) and C(2)H(4) involving primary cations can be controlled by the pore volume of a zeolite.
<title>Estimation of lean and fat composition of pork ham using image processing measurements</title> (1995)

This paper presents a method of estimating the lean and fat composition in pork ham from cross-sectional area measurements using image processing technology. The relationship between the quantity of ham lean and fat mass with the ham lean and fat areas was studied. The prediction equations for pork ham composition based on the ham cross-sectional area measurements were developed. The results show that ham lean weight was related to the ham lean area (r equals .75, P &lt; .0001) while ham fat weight was related tot the ham fat area (r equals .79, P equals .0001). Ham lean weight was highly related to the product of ham total weight times percentage ham lean area (r equals .96, P &lt; .0001). Ham fat weight was highly related to the product of ham total weight times percentage ham fat area (r equals .88, P &lt; .0001). The best combination of independent variables for estimating ham lean weight was trimmed wholesale ham weight and percentage ham fat area with a coefficient of determination of 92%. The best combination of independent variables for estimating ham fat weight was trimmed wholesale ham weight and percentage ham fat area with a coefficient of determination of 78%. Prediction equations with either two or three independent variables did not significantly increase the accuracy of prediction. The results of this study indicate that the weight of ham lean and fat could be predicted from ham cross-sectional area measurements using image analysis in combination with wholesale ham weight.
Positioning Characteristics of a MEMS Linear Motor Utilizing a Thin Film Permanent Magnet and DLC Coating (2013)

A high performance Nd 2 Fe 14 B/Ta thin film Permanent Magnet (PM) not only has a high remnant flux density and a high coercive force similar to those of a conventional sintered Nd 2 Fe 14 B magnet, but also has a high heat tolerance. Using a thin film PM, we developed a moving-magnet typeMEMS linearmotor consisting of a silicon slider including a multi-pole magnetized thin film PM, a linear guideway made from silicon, and a two-phase micro-coil. Diamond-Like Carbon (DLC) coatings were used in order to reduce the friction force between the slider and the guideway. The purpose of this study is to realize feedback positioning of the MEMS linear motor and to investigate the dynamics of the linear motor system. In a driving experiment, the minimum current and voltage to start the slider were less than 0.26 A and 0.6 V, respectively. In positioning tests, the positioning resolution and bandwidth were 100 µm and 54 Hz, respectively.
Digital Volume Pulse Measured at the Fingertip as an Indicator of Diabetic Peripheral Neuropathy in the Aged and Diabetic (2019)

This study investigated the application of a modified percussion entropy index (PEIPPI) in assessing the complexity of baroreflex sensitivity (BRS) for diabetic peripheral neuropathy prognosis. The index was acquired by comparing the obedience of the fluctuation tendency in the change between the amplitudes of continuous digital volume pulse (DVP) and variations in the peak-to-peak interval (PPI) from a decomposed intrinsic mode function (i.e., IMF6) through ensemble empirical mode decomposition (EEMD). In total, 100 middle-aged subjects were split into 3 groups: healthy subjects (group 1, 48–89 years, n = 34), subjects with type 2 diabetes without peripheral neuropathy within 5 years (group 2, 42–86 years, n = 42, HbA1c ≥ 6.5%), and type 2 diabetic patients with peripheral neuropathy within 5 years (group 3, 37–75 years, n = 24). The results were also found to be very successful at discriminating between PEIPPI values among the three groups (p &lt; 0.017), and indicated significant associations with the anthropometric (i.e., body weight and waist circumference) and serum biochemical (i.e., triglycerides, glycated hemoglobin, and fasting blood glucose) parameters in all subjects (p &lt; 0.05). The present study, which utilized the DVP signals of aged, overweight subjects and diabetic patients, successfully determined the PPI intervals from IMF6 through EEMD. The PEIPPI can provide a prognosis of peripheral neuropathy from diabetic patients within 5 years after photoplethysmography (PPG) measurement.
Review on VCO based ADC in modern deep submicron CMOS technology (2012)

The continuous scaling in CMOS technology has driven researchers to look for new ADC architecture that can work well in lower supply voltage and smaller device dimension. VCO-based ADCs have emerged as an attractive solution due to its highly digital intensive circuit architecture, inherent noise shaping characteristic, as well as anti-aliasing property. However, the nonlinear behavior of VCO's voltage-to-frequency characteristic has severe limitation on the performance of VCO-based ADC. This paper presents recent development in VCO-based ADC with different VCO nonlinearity suppression techniques. The advantage and disadvantage of each of these techniques will be reviewed.
Loss of legal status has caused crisis in health visiting, says union (2009)

Health visiting needs to be recognised as a distinct profession to halt a crisis threatening the care of vulnerable children, union leaders are warning.