gebhart/patrepeval huggingface dataset:
INFLUENCE OF TEMPORAL STRUCTURE OF THE SONIC ENVIRONMENT ON ANNOYANCE (2023)

The relationship between environmental noise exposure and annoyance has been well-investigated and well-documented, insofar that the European Commission includes estimated annoyance as an evaluation measure for the impact of noise exposure (2002-49-EC). Although exposure-effect relationships for different sources have been generally accepted, the uncertainty in these models remains substantial (Marquis-Favre et al. 2005; Fields et al. 2000) for example have calculated that the response between communities differs on average by the equivalent of about 7 dB in noise exposure. One major issue here is the contribution of non-acoustical factors (Fields 1993) and another the uncertainty of the exposure modeling method (Lercher et al. 2008b).
Supplementary Figure 3 from Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors (2023)

Supplementary Figure 3 from Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors
Constraint-based interactive assembly planning (2002)

Constraints on assembly plans vary depending on product, assembly facility, assembly volume, and many other factors. This paper describes the principles and implementation of a framework that supports a wide variety of user-specified constraints for interactive assembly planning. Constraints from many sources can be expressed on a sequences level, specifying orders and conditions on part mating operations in a number of ways. All constraints are implemented as filters that either accept or reject assembly operations proposed by the planner. For efficiency, some constraints are supplemented with special-purpose modifications to the planner's algorithms. Fast replanning enables a natural plan-view-constrain-replan cycle that aids in constraint discovery and documentation. We describe an implementation of the framework in a computer-aided assembly planning system and experiments applying the system to several complex assemblies.
Data-Driven Wireless Anomaly Detection Using Spectral Features (2022)

In this work, we present an anomaly detection algorithm for wireless spectrum data and evaluate its ability to accurately detect interfering transmissions. The algorithm considers three types of interfering signals: a co-channel transmission, an interfering continuous-wave transmission, or an adversarial replay attack. At the core of each anomaly detector is a feature space transformation, which learns a compressed representation of the data, followed by various metrics on this representation. Four feature space transformations and four detection metrics are investigated, each of which represents different characterizations of the distribution of the data, totaling 16 configurations of the anomaly detector. Our algorithm is evaluated using Wi-Fi spectrum data from real-world radio frequency (RF) captures in both mild and harsh channel conditions. We present an analysis of the performance of the various configurations under each of the interference types at varying signal-to-interference ratios. Lastly, we discuss the implications of this performance on the the distribution of the data and the recommended model to detect each type of anomaly.
System Losses and Assessment Trade Study (2009)

This Advanced Fuel Cycle Initiative (AFCI) study has developed new analysis methods to examine old and new technology options toward the goal of improving fuel cycle systems. We have integrated participants and information from AFCI Systems Analysis, Transmutation Fuels, Separations, and Waste Form Campaigns in the Systems Losses and Assessment Trade Study. The initial objectives of this study were to 1) increase understanding of system interdependencies and thereby identify system trade-offs that may yield important insights, 2) define impacts of separations product purity on fuel manufacture and transmutation reactivity, 3) define impacts from transuranic (TRU) losses to waste, 4) identify the interrelationships involved in fuels and separations technology performance, and 5) identify system configuration adjustments with the greatest potential for influencing system losses. While bounding and analyzing this initial problem, we also identified significantly higher-level programmatic drivers with broad implications to the current fuel cycle research charter and the general issue of a DOE complex wide need for a comprehensive and integrated nuclear material management as addressed by the new DOE Order 410.2 titled “Management of Nuclear Materials”. The initial modeling effort developed in this study for a much smaller subset of material (i.e., commercial fuel) and a selected transmutation scheme (i.e., fast reactor recycling) is a necessary first step towards examining a broader set of nuclear material management options, dispositioning strategies and integrated waste management options including potential areas of research leverage. The primary outcome from this initial study has been an enhanced integration among Campaigns and associated insights and analysis methods. Opportunities for improved understanding between the groups abound. The above lanthanide-actinide example highlights the importance of evaluating options via integration across the Campaigns. Plans for Fiscal Year 2010 are being made in a coordinated fashion such that the knowledge gained from the research performed by the Campaigns can benefit on-going work of the study, and that improved understanding of the system relationships can be used to guide the specific research and development (R&D) activities within the Campaigns. In FY-10, the System Losses and Assessment Trade Study will carry-over activities from FY-09. We will continue to refine impurity and loss estimates and impurity limits on fuels by incorporating results from ongoing R&D. And we will begin work on an enhanced nuclear material management model to allow us to continue to improve our overall system understanding of the trade-offs between separations, fuel fabrication, waste forms, waste disposition, SNM losses, reactor performance, and proliferation resistance. In the future, we can also better understand how used fuel and other forms of remote-handled SNM can be better integrated into an overall nuclear material management program that will evolve for the DOE complex via Order 410.2 (DOE 2009).
Photocurable Coatings (1990)

Since the introduction of photocuring of coatings as a viable industrial process well over a decade ago, the UV curing industry has followed a line of steady growth. This paper deals with the mechanisms and components which characterize photocurable coatings. Free radical and cationic photoinitiated polymerization are discussed in light of key review references from the recent literature. In addition, a section is dedicated to discussion of the lamp sources available for photocuring operations.
Sharing and Specificity of Co-expression Networks across 35 Human Tissues (2015)

To understand the regulation of tissue-specific gene expression, the GTEx Consortium generated RNA-seq expression data for more than thirty distinct human tissues. This data provides an opportunity for deriving shared and tissue specific gene regulatory networks on the basis of co-expression between genes. However, a small number of samples are available for a majority of the tissues, and therefore statistical inference of networks in this setting is highly underpowered. To address this problem, we infer tissue-specific gene co-expression networks for 35 tissues in the GTEx dataset using a novel algorithm, GNAT, that uses a hierarchy of tissues to share data between related tissues. We show that this transfer learning approach increases the accuracy with which networks are learned. Analysis of these networks reveals that tissue-specific transcription factors are hubs that preferentially connect to genes with tissue specific functions. Additionally, we observe that genes with tissue-specific functions lie at the peripheries of our networks. We identify numerous modules enriched for Gene Ontology functions, and show that modules conserved across tissues are especially likely to have functions common to all tissues, while modules that are upregulated in a particular tissue are often instrumental to tissue-specific function. Finally, we provide a web tool, available at mostafavilab.stat.ubc.ca/GNAT, which allows exploration of gene function and regulation in a tissue-specific manner.
Femoral Component Revision with Use of Impaction Bone-Grafting and a Cemented Polished Stem (2006)

Femoral revision with use of an impaction bone-grafting technique and a cemented polished stem resulted in an excellent prosthetic survival rate at eight to thirteen years postoperatively. The major problem that occurred was a femoral fracture in four patients.
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease (2006)

Proteases are required for the production of peptide neurotransmitters and toxic peptides in neurodegenerative diseases. Unique roles of the cysteine proteases cathepsin L and cathepsin B in secretory vesicles for the production of biologically active peptides have been demonstrated in recent studies. Secretory vesicle cathepsin L participates in the proteolytic conversion of proenkephalin into the active enkephalin, an opioid peptide neurotransmitter that mediates pain relief. Moreover, recent findings provide evidence that cathepsin B in regulated secretory vesicles participates in the production of toxic beta-amyloid peptides that are known to accumulate extracellularly in Alzheimer's disease brains. The neurobiological functions of cathepsins L and B demonstrate that these secretory vesicle cysteine proteases produce biologically active peptides. These results demonstrate newly identified roles for cathepsins L and B in neurosecretory vesicles in the production of biologically active peptides.
GNDD: A Graph Neural Network-Based Method for Drug-Disease Association Prediction (2019)

Potential drug-disease association prediction is important to facilitate drug discovery. However, most of existing drug-disease association prediction approaches rely on assembling multiple drug (disease)-related biological information, which is usually not comprehensively available, and they always fail to explore the latent information in drug-disease network. To tackle these challenges, we propose a graph neural network-based method for drug-disease association prediction, dubbed GNDD, with capturing the complex information between drugs and diseases dispense with any side information. Specifically, GNDD introduces the idea of collaborative filtering in recommendation system to avoid the dependency on multi-data. Furthermore, an embedding propagation strategy is exploited to model the high-order relationships in drug-disease network. We conduct experiments on the Comparative Toxicogenomics Database, demonstrating the effectiveness of our method in drug-disease association prediction.
Influence of Third Particle on the Tribological Behaviors of Diamond-like Carbon Films (2016)

Tribological mechanisms of diamond-like carbon (DLC) films in a sand-dust environment are commonly unclear due to the complicated three-body abrasion caused by sand particles. This study investigates the three-body abrasion of the DLC film via molecular dynamics simulations. The influence factors such as the load, velocity, shape of the particle and its size are considered. It has been found that the friction and wear of the DLC film are determined by adhesion at a small load but dominated by both adhesion and plowing at a large load. A high velocity can increase the friction of the DLC film but decrease its wear, due to the response of its networks to a high strain rate indicated by such velocity. The shape of the particle highly affects its movement mode and thus changes the friction and wear of the DLC film. It is found that a small-sized particle can increase the friction and wear of the DLC film by enhancing plowing. These unique tribological mechanisms of the DLC film can help to promote its wide applications in a sand-dust environment.
Transmission of variable bit-rate MPEG-2 video streams over ATM: applications, challenges, and techniques (2002)

Compressed digital video is inherently variable rate since its complexity and motion content directly affect the encoding rate. This paper addresses the issues in encoding variable rate MPEG video for transmission applications to realize bandwidth savings while maintaining quality. The applications and benefits of variable rate encoding are compared with constant rate encoding. Variable rate encoding is commonly used in storage applications such as digital versatile discs (DVDs). In these applications the bit utilization is optimized over the entire encoding session to produce a desired peak and average rate for the stream. This rate control approach may not be ideal for transmission applications since it does not bound the burstiness of the stream. Experimental results are presented to demonstrate the feasibility of transmitting variable rate MPEG streams over an ATM network. The traffic parameters for these streams are analyzed for several encoding options. The bandwidth saving is quantified by estimating the effective bandwidth of variable rate streams and comparing it with the bandwidth of constant rate streams of similar quality.
Nutritional Proteins in Milk and the Protein Requirement of Normal Infants (1985)

All whey proteins in human milk are not absorbed and thus not nutritionally available. There is evidence that secretory immunoglobulin A (SIgA), lactoferrin, and lysozyme are resistant to proteolytic action, and the major part of these protective proteins is excreted in the infant's stool. An exclusively breast-fed infant would thus have a mean intake of 1.3 g of protein per kilogram of body weight per day during the first month and about 0.9 g/kg/d during the third month. Term infants fed with formulas containing 1.5 g of protein per deciliter show metabolic changes that indicate that the infants receive more protein than they require for growth; these changes are not seen in breast-fed infants or in infants receiving a whey-predominant formula containing only 1.1 g/dL of protein. A reevaluation of protein requirement and intake during infancy is suggested.
Effect of outer wing separation on lift and thrust generation in a flapping wing system (2011)

We explore the implementation of wing feather separation and lead-lagging motion to a flapping wing. A biomimetic flapping wing system with separated outer wings is designed and demonstrated. The artificial wing feather separation is implemented in the biomimetic wing by dividing the wing into inner and outer wings. The features of flapping, lead-lagging, and outer wing separation of the flapping wing system are captured by a high-speed camera for evaluation. The performance of the flapping wing system with separated outer wings is compared to that of a flapping wing system with closed outer wings in terms of forward force and downward force production. For a low flapping frequency ranging from 2.47 to 3.90 Hz, the proposed biomimetic flapping wing system shows a higher thrust and lift generation capability as demonstrated by a series of experiments. For 1.6 V application (lower frequency operation), the flapping wing system with separated wings could generate about 56% higher forward force and about 61% less downward force compared to that with closed wings, which is enough to demonstrate larger thrust and lift production capability of the separated outer wings. The experiments show that the outer parts of the separated wings are able to deform, resulting in a smaller amount of drag production during the upstroke, while still producing relatively greater lift and thrust during the downstroke.
Cooperative multi-robot navigation and mapping of unknown terrain (2011)

We describe the hardware, software and sensor equipment for a fleet of mobile robots used for cooperative multi-robot navigation and mapping. This robot team was developed for the MAGIC 2010 Robotics Challenge and successfully made it through two down-selection processes to the finals, where it placed 4th. Our mobile robot design leverages off-the-shelf hardware and open source software with novel software contributions to realize cooperative navigation, mapping, reconnaissance, and surveillance tasks for a large urban environment.
Minority Trauma Patients Tend to Cluster at Trauma Centers with Worse-Than-Expected Mortality (2013)

Minority trauma patients are clustered at hospitals with significantly higher-than-expected mortality. Black and Hispanic patients treated at low-mortality hospitals have a significantly lower odds of death than similar patients treated at high-mortality hospitals. Differences in TC outcomes and quality of care may partially explain trauma outcomes disparities.
Operations of Shared Autonomous Vehicle Fleet for Austin, Texas, Market (2015)

The emergence of automated vehicles holds great promise for the future of transportation. Although commercial sales of fully self-driving vehicles will not commence for several more years, once these sales are possible a new transportation mode for personal travel promises to arrive. This new mode is the shared autonomous (or fully automated) vehicle (SAV), combining features of short-term, on-demand rentals with self-driving capabilities: in essence, a driverless taxi. This investigation examined the potential implications of the SAV at a low level of market penetration (1.3% of regional trips) by simulating a feet of SAVs serving travelers in the 12-mi by 24-mi regional core of Austin, Texas. The simulation used a sample of trips from the region's planning model to generate demand across traffic analysis zones and a 32,272-link network. Trips called on the vehicles in 5-min departure time windows, with link-level travel times varying by hour of day based on MATSIM's dynamic traffic assignment simulation software. Results showed that each SAV could replace about nine conventional vehicles within the 24-mi by 12-mi area while still maintaining a reasonable level of service (as proxied by user wait times, which averaged just 1 min). Additionally, approximately 8% more vehicle miles traveled (VMT) may be generated because of SAV's ability to journey unoccupied to the next traveler or relocate to a more favorable position in anticipation of its next period demand.
Switched Reluctance Motors and Their Control (1993)

Introduction 1. Energy conversion principles 2. Motor design 3. Dynamic operation 4. Computer-aided design 5. The power-electronic controller 6. Control strategies 7. Losses and cooling 8. Applications 9. Example design 10. Tests and measurements References Index
Magnetocaloric effect and electrical properties of (0.95)La0.45Nd0.25Sr0.3MnO3/(0.05)CuO composites (2020)

Abstract In this work, the structural, magnetic and magnetocaloric properties of 0.95La 0.45 Nd 0.25 Sr 0.3 MnO 3 /0.05CuO composites materials were investigated. The samples have been synthesized by solid-state reaction route. The XRD patterns of composites powders show the presence of both perovskite La 0.45 Nd 0.25 Sr 0.3 MnO 3 and monoclinic Tenorite CuO materials. The microstructural characterization performed using Scanning Electron Microscope shows that copper oxide nanostructure is located in the grains boundaries after pressing. According to the isothermal magnetization measurements around the Curie temperature, the maximum isothermal magnetic entropy change is calculated to be 4.128 J/(Kg.K) at 5 T for the pellet with an interesting enhancement compared to the powder sample 2.7 J/(Kg.K). The relative cooling power is about 212.8 J Kg −1 . Resistivity measurements under different magnetic fields were performed in order to investigate the magnetoresistance properties. The obtained magnetocaloric properties show that 0.95La 0.45 Nd 0.25 Sr 0.3 MnO 3 /0.05CuO composite was an attractive candidate material for magnetic refrigeration application. About magnetoresistance properties the (% MR) is found to be 32.78% around 320 K under a magnetic field of 5 T.
BAX-BAK heterodimer as a pharmacodynamic biomarker of on-target drug action of Mcl-1 inhibitors to evaluate in-vivo effectiveness. (2018)

2582 Background: Clinical development of promising small molecule Mcl-1 inhibitors is underway. The Mcl-1 inhibitors act by disrupting complexes of Mcl-1 with pro-apoptotic proteins such as BAK/BIM/Noxa, leading to formation of oligomers of BAK and BAX at the mitochondrial membrane and activation of an apoptosis cascade. Therefore, measurement of BAX-BAK heterodimers on the mitochondrial membrane is considered an on-target pharmacodynamic (PD) biomarker for this class of drugs. We describe use of the BAX-BAK assay to screen and prioritize small molecule Mcl-1 inhibitors (Taekyu et al, FEBS Let 2017) for on-target activity and in vivo potency in relevant cancer models. Methods: The BAX-BAK heterodimer immunoassay was developed on the Luminex platform using monoclonal antibodies specific to active BAX and BAK proteins. Single-dose PD and PK of each Mcl-1 inhibitor was evaluated at 100-mg/kg (IP) in nude mice bearing AMO-1 (myeloma) or NCI-H929 xenografts. Tumors quadrants were collected at 4, 8, 12, 18 and 24 hours after dosing, mitochondrial (mito.) fractions prepared, and biomarkers measured as described previously (Srivastava et al, Clin Can Res 2016). Results: The sandwich oassay provided a reliable, quantitative measurement of BAX-BAK levels in mito. fractions from both in-vitro (AMO-1, MOLP-8, MOLT-4, NCI-H929) and in-vivo xenograft (AMO-1, NCI-H929) models. The PD study showed a wide range of BAX-BAK activation, with the most potent compounds causing a 10-20 fold increase in peak BAX-BAK levels between 4-18 hours after dosing. Compounds that produced the highest levels of BAX-BAK also produced the highest cleaved caspase-3 levels and were associated with the highest tumor drug concentrations. The PD biomarker strategy, in conjunction with PK, prioritized select compounds for further development. Conclusions: We describe the application of a BAX-BAK heterodimer assay to effectively identify potent Mcl-1 inhibitors with early proof of on-target activity in tumor tissue. The PD biomarker could provide a benchmark assay to compare and contrast potency and mechanism-of-action of Mcl-1 inhibitors in clinical studies. Funded by NCI Contract No HHSN261200800001E.
Synthesis, characterization, and preceramic properties of π-conjugated polymers based on Ni(II) complexes of goedken's macrocycle (2016)

Nickel(II) complexes of Goedken's macrocycle bearing alkyne substituents were copolymerized with 2,7-dibromo-9,9-dihexylfluorene, 2,5-dibromo-3-hexylthiophene, and 1,4-dibromo-2,5-bis(hexyloxy)benzene via microwave-induced Sonogashira cross-coupling reactions to produce copolymers 6F, 6T, and 6B. The spectroscopic and electrochemical properties of the copolymers were examined and compared to model compounds. Specifically, each polymer exhibited a nickel-based absorption centered at about 589 nm and two π → π* transitions between 272 and 387 nm. While the copolymers did not exhibit extended π conjugation, the nature of the organic spacer did affect the high energy transitions. Furthermore, each copolymer underwent two ligand-based one-electron oxidations at potentials of about 0.24 V and about 0.75 V relative to the ferrocene/ferrocenium redox couple. Postpolymerization functionalization of the alkyne group in 6F with Co2(CO)8 afforded a novel heterobimetallic copolymer that yielded amorphous nanomaterials containing Ni/Co when pyrolyzed at 800 °C for 3 h under an atmosphere of N2/H2 (95:5). © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3257–3266
Association of Hormonal Contraceptive Use with Headache and Temporomandibular Pain: The OPPERA Study (2021)

These findings imply that HC influences craniofacial pain, and that this pain diminishes after cessation of HC use.