gebhart/patrepeval huggingface dataset:
Rotheca serrata Flower Bud Extract Mediated Bio-Friendly Preparation of Silver Nanoparticles: Their Characterizations, Anticancer, and Apoptosis Inducing Ability against Pancreatic Ductal Adenocarcinoma Cell Line (2023)

Over past decades, the green method of synthesizing metal nanoparticles has acquired more attentiveness by scientific consensus because of its industrial and biomedical applications. This study focuses on the anti-proliferative effectiveness of AgNPs synthesized from Rotheca serrata (L.) Steane &amp; Mabb. flower bud extract against the PANC-1 cell line in vitro. Various analytical instruments were utilized to visualize the formation of RsFb-AgNPs, such as UV-Vis spectroscopy, FT-IR, SEM, EDS, TEM, XRD, Zeta potential, and DLS analysis. The biosynthesis of RsFb-AgNPs was observed by a change in color and UV-Vis spectroscopy (415 nm). The FT-IR spectra exhibited the existence of many functional groups. XRD confirmed the crystallinity of the AgNPs. Morphology and elemental mapping were assessed by SEM and EDS analysis. The TEM micrograph revealed spherical-shaped particles with sizes ranging from 12 to 40 nm. Zeta potential and DLS analysis were used to measure surface charge and particle size. Biological properties, including the antioxidant, antimicrobial, and anticancer properties of synthesized RsFb-AgNPs, exhibited dose-dependent activities. In DPPH assay, synthesized RsFb-AgNPs inhibited the scavenging of free radicals in a dose-dependent manner. In addition, the resultant RsFb-AgNPs displayed moderate antimicrobial activity against tested pathogens. Further, the anti-proliferative efficacy of biosynthesized RsFb-AgNPs was determined against the PANC-1 cell line using the MTT assay. The results revealed a dose-dependent decrease in viability of cancer cells with an IC50 value of 36.01 µg/mL. Flow cytometry was then used to confirm the apoptotic effects by double staining with annexin V/PI. In response to the pancreatic ductal adenocarinoma cell line, the results showed notable early and late apoptosis cell population percentages. In conclusion, the synthesized RsFb-AgNPs revealed a potential anticancer agent that can induce apoptosis in the PANC-1 cells.
Correlation Between Opsonic Activity for Various Microorganisms and Composition of Gammaglobulin Preparations for Intravenous Use (1984)

In this study 12 commercial immunoglobulin preparations for intravenous administration were investigated with respect to their opsonic activity for various strains of Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, and group B streptococci, and in addition, the concentration of unsplit IgG molecules, IgG fragments, and IgG aggregates (dimers) was determined. The results show that four preparations that had been treated with enzyme or by reduction and alkylation had hardly any opsonic activity; the other preparations were as effective as inactivated serum. A statistical analysis showed an excellent correlation between the concentration of intact IgG molecules in a preparation and the opsonic activity for the various bacteria; a negative correlation between the concentration of IgG fragments and the opsonic activity was found. The combination of the two techniques used in this study provides a basis for recommendations on the choice of gammaglobulin preparations for clinical use.
BOOK REVIEWS (1990)

Journal Article BOOK REVIEWS Get access PREVENTING CAN DEATHS. By CYRIL GREENLAND. (New York and London: Tavistock, 1987. 217 pp £28.00 hb.) M. D. A. Freeman M. D. A. Freeman Faculty of Laws, University CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 30, Issue 2, Spring 1990, Pages 259–260, https://doi.org/10.1093/oxfordjournals.bjc.a048004 Published: 01 March 1990
Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction (2017)

Diabetic retinopathy (DR) is a well-known microvascular complication related to inflammation. Mcc950 is a potent and specific inhibitor of the NLRP3 inflammasome but its influence on DR has not been studied. Thus, we evaluated the anti-inflammatory effects of Mcc950 on high-glucose-induced human retinal endothelial cells (HRECs) and the potential underlying mechanism. In surgical excised proliferative membranes from DR patients, high expression of NLRP3, caspase 1 and IL-1β was observed and co-localization of NLRP3 and IL-1β occurred in CD31+ labeled HRECs. Moreover, in high-glucose-stimulated HRECs, increased production of the NLRP3 inflammasome activation and severe apoptosis were rescued with Mcc950 treatment. Additionally, the inhibitory effect of Mcc950 was mimicked through downregulation of NEK7 by siRNA in high-glucose-induced HRECs and Mcc950 treatment remarkably inhibited Nek7 and NLRP3 interactions by co-immunoprecipitation, suggesting that Mcc950 may be a potentially protective agent against inflammation, likely via downregulation of the Nek7-NLRP3 pathway. In conclusion, Mcc950 inhibited HREC dysfunction under high-glucose conditions and this research may offer insight for future pharmaceutical approaches for treating DR.
FIRE AND FLAMMABILITY CHARACTERISTICS OF MATERIALS USED IN RAIL PASSENGER CARS. A LITERATURE SURVEY (1980)

A literature search was conducted to provide information on the flammability characteristics of materials that are used, or have potential use, in furnishing the interiors of rail passenger cars. Among the characteristics of interest were the ignition temperature, time to reach ignition, the rate of flame spread, the rate of combustion or rate of material loss, rate of heat liberation, heat transfer from flames, the evaluation of smoke, the measurement of smoke density, and the evolution and toxicological effect of the products of combustion. In addition, information was collected on flammability test methods, fire prevention standards or codes, and statistical data concerning accidents involving vehicle fires of interior origin. The information compiled is to be used to assist the Federal Railroad Administration, Department of Transportation (FRA/DOT) in establishing safety standards regarding the flammability of the materials used in the interiors of rail passenger cars. 226 References are given.
Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B/v-Akt murine thymoma viral oncogene -endothelial nitric oxide synthase pathway to alleviate hypertension in SHR. Cg-Leprcp/NDmcr rats (2018)

tCA attenuated endothelial dysfunction and reduced blood pressure in SHR-CP rats. The underlying mechanisms may involve the increase in AKT and eNOS phosphorylation and the release of eNOS-derived NO.
Injection and charge transport processes of polymer light emitting diodes (1996)

We investigated thianthrene (TH) and 2-(4-biphenyl)-5-(4-t-butylphenyl)-1,3,4-oxadiazole (PBD), which is known to be a good scintillator dye and have good electron transport properties, separately by cyclic voltammetry in solution. All electrochemical measurements were performed in solutions of N-methylporrolidone in the reduction region and in acetonitrile (for PBD) and dichloromethane (for TH) in the oxidation direction. We also investigated the current-voltage (I-U) characteristics for testing the diode character and capacitance-voltage (C-V) behaviour of different single and double layer structures to describe the function of such devices. For LED fabrication, TH and PBD were mixed with 20% polycarbonate (PC) dissolved in chloroform, so that a mixed single layer with a thickness of 150 nm as an LED blend structure was built up.
QSCOUT: Quantum Scientific Computing Open User Testbed (2022)

The 53rd Annual Meeting of the APS Division of Atomic, Molecular and Optical Physics will take place from May 30 – June 3, 2022 in Orlando, Fl, USA. <a href="https://morressier.zoom.us/j/89880865272?pwd=SWxTRGhra1ZOSDBrSkhVZDBzVDR6UT09/">Virtual Presenter Help Desk</a>
Isolation and selection of bacteria and yeasts antagonistic to preharvest infection of avocado by Colletotrichum gloeosporioides (1995)

Bacteria and yeasts were isolated from leaves, flowers and fruit of avocado trees that had not been sprayed with pesticides for several years. Of the 1050 microorganisms isolated, 37% inhibited mycelial growth of Colletotrichum gloeosporioides on potato dextrose agar. Many of these organisms also significantly reduced spore germination of the fungus on cellophane overlaying weak sugars agar and a greater proportion of yeasts than bacteria were more effective. Some bacteria and yeasts also reduced spore germination of the pathogen on avocado leaf disks. The predominant group of suppressive bacteria was Bacillus spp., and the antagonistic yeasts included Aureobasidium spp. and a variety of pink and white colony types. Antibiotic resistant isolates of Bacillus, carbendazim resistant isolates of two yeasts and an Aureobasidium sp. were sprayed on avocado leaves and survived for at least 2 months on the phylloplane. On the basis of performance in these tests, isolates with biocontrol and colonization potential were selected and tested for their capacity to provide disease control on fruit. In repeated tests, several bacteria and yeasts consistently reduced lesion development and lesion size on detached avocado fruit when applied prior to inoculating fruit with the pathogen.
A computational study of syngas auto-ignition characteristics at high-pressure and low-temperature conditions with thermal inhomogeneities (2015)

A computational study was conducted to investigate the characteristics of auto-ignition in a syngas mixture at high-pressure and low-temperature conditions in the presence of thermal inhomogeneities. Highly resolved one-dimensional numerical simulations incorporating detailed chemistry and transport were performed. The temperature inhomogeneities were represented by a global sinusoidal temperature profile and a local Gaussian temperature spike (hot spot). Reaction front speed and front Damköhler number analyses were employed to characterise the propagating ignition front. In the presence of a global temperature gradient, the ignition behaviour shifted from spontaneous propagation (strong) to deflagrative (weak), as the initial mean temperature of the reactant mixture was lowered. A predictive Zel'dovich–Sankaran criterion to determine the transition from strong to weak ignition was validated for different parametric sets. At sufficiently low temperatures, the strong ignition regime was recovered due to faster passive scalar dissipation of the imposed thermal fluctuations relative to the reaction timescale, which was quantified by the mixing Damköhler number. In the presence of local hot spots, only deflagrative fronts were observed. However, the fraction of the reactant mixture consumed by the propagating front was found to increase as the initial mean temperature was lowered, thereby leading to more enhanced compression-heating of the end-gas. Passive scalar mixing was not found to be important for the hot spot cases considered. The parametric study confirmed that the relative magnitude of the Sankaran number translates accurately to the quantitative strength of the deflagration front in the overall ignition advancement.
Osteoarthritis - management options in general practice. (2010)

Following diagnosis based primarily on history and examination, management focuses on optimising quality of life by providing self management advice combined with appropriate pharmacological and nonpharmacological strategies, aiming to reduce acute exacerbations, prevent complications and delay progression.
Application of Forward Modelling and Dictionary Indexing to EBSD Orientation Data as a Means of Quantifying Dislocation Substructure Formation in FCC Metals (2019)

Journal Article Application of Forward Modelling and Dictionary Indexing to EBSD Orientation Data as a Means of Quantifying Dislocation Substructure Formation in FCC Metals Get access Daniel L Foley, Daniel L Foley Department of Materials Science and Engineering, Drexel University, Philadelphia. PA, USA Search for other works by this author on: Oxford Academic Google Scholar Cassandra Pate, Cassandra Pate Department of Materials Science and Engineering, Drexel University, Philadelphia. PA, USA Search for other works by this author on: Oxford Academic Google Scholar Kyle Matthews, Kyle Matthews Department of Materials Science and Engineering, Drexel University, Philadelphia. PA, USA Search for other works by this author on: Oxford Academic Google Scholar Xingyuan Zhao, Xingyuan Zhao Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA, USA Search for other works by this author on: Oxford Academic Google Scholar Nicolas Savino, Nicolas Savino Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA, USA Search for other works by this author on: Oxford Academic Google Scholar Marc DeGraef, Marc DeGraef Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, USA Search for other works by this author on: Oxford Academic Google Scholar Leslie Lamberson, Leslie Lamberson Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA, USA Search for other works by this author on: Oxford Academic Google Scholar Mitra L Taheri Mitra L Taheri Department of Materials Science and Engineering, Drexel University, Philadelphia. PA, USA Corresponding author: mlt48@drexel.edu Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 25, Issue S2, 1 August 2019, Pages 208–209, https://doi.org/10.1017/S1431927619001776 Published: 01 August 2019
Cytokines and chemokines in follicular fluids and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor (2008)

Individual FF composition is related to the development of the corresponding in vitro generated embryo and its potential of implantation. Individual FF G-CSF may provide a non-invasive biomarker of implantation that needs to be evaluated together with in vitro observation to select the oocyte, and hence the embryo, to transfer.
Natural variation and gene regulatory basis for the responses of asparagus beans to soil drought (2015)

Asparagus bean (Vigna unguiculata ssp. sesquipedalis) is the Asian subspecies of cowpea, a drought-resistant legume crop native to Africa. In order to explore the genetic variation of drought responses in asparagus bean, we conducted multi-year phenotyping of drought resistance traits across the Chinese asparagus bean mini-core. The phenotypic distribution indicated that the ssp. sesquipedalis subgene pool has maintained high natural variation in drought responses despite known domestic bottleneck. Thirty-nine SNP loci were found to show an association with drought resistance via a genome-wide association study (GWAS). Whole-plant water relations were compared among four genotypes by lysimetric assay. Apparent genotypic differences in transpiration patterns and the critical soil water threshold in relation to dehydration avoidance were observed, indicating a delicate adaptive mechanism for each genotype to its own climate. Microarray gene expression analyses revealed that known drought resistance pathways such as the ABA and phosphate lipid signaling pathways are conserved between different genotypes, while differential regulation of certain aquaporin genes and hormonal genes may be important for the genotypic differences. Our results suggest that divergent sensitivity to soil water content is an important mechanism configuring the genotypic specific responses to water deficit. The SNP markers identified provide useful resources for marker-assisted breeding.
Optical studies of carrier kinetics in a type II multiple quantum well hetero-n-i-p-i structure (1997)

In this paper, carrier kinetics in a type II multiple quantum well hetero-n-doped-intrinsic–p-doped-intrinsic are studied through optical measurements under continuous illumination. Both field measurement by photoreflectance and time measurement confirmed our hypothesis that the recombination time is a function not only of photocarrier density, but also of photocarrier distribution. A simple model is used for recombination time, assuming exponential dependence on the barrier height and nearest distance between recombining carriers. Quantum efficiency has also been determined.
Unsupervised models for morpheme segmentation and morphology learning (2007)

We present a model family called Morfessor for the unsupervised induction of a simple morphology from raw text data. The model is formulated in a probabilistic maximum a posteriori framework. Morfessor can handle highly inflecting and compounding languages where words can consist of lengthy sequences of morphemes. A lexicon of word segments, called morphs , is induced from the data. The lexicon stores information about both the usage and form of the morphs. Several instances of the model are evaluated quantitatively in a morpheme segmentation task on different sized sets of Finnish as well as English data. Morfessor is shown to perform very well compared to a widely known benchmark algorithm, in particular on Finnish data.
Snapscreen: TV-stream frame search with projectively distorted and noisy query (2017)

In this work we describe an approach to real-time image search in large databases robust to variety of query distortions such as lighting alterations, projective distortions or digital noise. The approach is based on the extraction of keypoints and their descriptors, random hierarchical clustering trees for preliminary search and RANSAC for refining search and result scoring. The algorithm is implemented in Snapscreen system which allows determining a TV-channel and a TV-show from a picture acquired with mobile device. The implementation is enhanced using preceding localization of screen region. Results for the real-world data with different modifications of the system are presented.
The Plasma Membrane as a Reservoir, Protective Shield, and Light‐Triggered Launch Pad for Peptide Therapeutics (2015)

Abstract Although peptide‐based therapeutics are finding increasing application in the clinic, extensive structural modification is typically required to prevent their rapid degradation by proteases in the blood. We have evaluated the ability of erythrocytes to serve as reservoirs, protective shields (against proteases), and light‐triggered launch pads for peptides. We designed lipidated peptides that are anchored to the surface of red blood cells, which furnishes a protease‐resistant environment. A photocleavable moiety is inserted between the lipid anchor and the peptide backbone, thereby enabling light‐triggered peptide release from erythrocytes. We have shown that a cell‐permeable peptide, a hormone (melanocyte stimulating hormone), and a blood‐clotting agent can be anchored to erythrocytes, protected from proteases, and photolytically released to create the desired biological effect.
Numerical modeling of illumination and detection methods for light-sheet microscopy of optically clear biological tissues (2017)

We utilize a recently developed fractal propagation method for modeling and assessing the performance of various light-sheet microscopy illumination and collection methods for imaging optically clear human tissues. Our simulation framework opens new possibilities for the design and optimization of next-generation light-sheet microscopes.
Abstract 130: Ox-LDL Impairs The Survival Of Bone Marrow Stem Cells Partially Through Membrane Damage Independent Of ROS Production In Vitro (2014)

Aims: cell-based therapy with bone marrow stem cells (MSCs) remains a viable option for tissue repair and regeneration. One of the major challenges for cell-based therapy is the limited survival of the cells after in vivo administration. The exact mechanism(s) for impaired in vivo survival of the implanted MSCs remains to be defined. Oxidized low-density lipid protein (ox-LDL) is a natural product in human blood, and the major contributor to the development of atherosclerosis. The present study was to investigate the effect of ox-LDL on the survival of bone marrow stem cells and the mechanisms in vitro. Methods and Results: Rat bone marrow multipotent adult progenitor cells (MAPCs) were treated with ox-LDL (with the final concentration of 10 and 20 ug/ml) for up to 48 hours. Exposure to ox-LDL resulted in significant cell death and apoptosis of MAPCs in association with a significant increase in LDH release in the conditioned media in a dose- and time-dependent manner, indicating significant cell membrane damage. The membrane damage was further confirmed with the rapid entry of the small fluorescent dye FM1-43 as detected using confocal microscope. Ox-LDL generated a significant amount of reactive oxygen species (ROS) in the culture system as measured with electron paramagnetic resonance spectroscopy. The antioxidant N-acetylcysteine (NAC, 0.1 mM) completely inhibited the production of ROS from ox-LDL. However, it didn’t prevent ox-LDL-induced cell death or apoptosis. However, pre-treatment of the cells with the specific membrane protective recombinant human MG53 protein (rhMG53)(66 ug/ml, final concentration) significantly, reduced LDH release and the entry of FM1-43 dye into the cells exposed to ox-LDL. Conclusion: Ox-LDL enhanced cell death and apoptosis of MAPCs with a mechanism independent of ROS generation in vitro. Ox-LDL impaired the survival of MAPCs partially through cell membrane damage in vitro.
30. Manfred Raetzsch (1998)

Type-2 diabetes increases the risk of colorectal cancer, and is also associated with low birth weight. However, we found no evidence of associations between birth characteristics and risk of colorectal cancer (m=248) among Swedish twins.
A Robust and Low-Complexity Source Localization Algorithm for Asynchronous Distributed Microphone Networks (2015)

In this paper, we propose a robust and low-complexity acoustic source localization technique based on time differences of arrival (TDOA), which addresses the scenario of distributed sensor networks in 3D environments. Network nodes are assumed to be unsynchronized, i.e., TDOAs between microphones belonging to different nodes are not available. We begin with showing how to select feasible TDOAs for each sensor node, exploiting both geometrical considerations and a characterization of the overall generalized cross correlation (GCC) shape. We then show how to localize sources in the space-range reference frame, where TDOA measurements have a clear geometrical interpretation that can be fruitfully used in the scenario of unsynchronized sensors. In this framework, in fact, the source corresponds to the apex of a hypercone passing through points described by the sole microphone positions and TDOA measurements. The localization problem is therefore approached as a hypercone fitting problem. Finally, in order to improve the robustness of the estimate, we include an outlier detection procedure based on the evaluation of the hypercone fitting residuals. A refinement of source location estimate is then performed ignoring the contributions coming from outlier measurements. A set of simulations shows the performance of individual blocks of the system, with particular focus on the effect of TDOA selection on source localization and refinement steps. Experiments on real data validate the localization algorithm in an everyday scenario, proving that good accuracy can be obtained while saving computational cost in comparison with state-of-the-art techniques.