gebhart/patrepeval huggingface dataset:
Data from Linkage and Microarray Analyses of Susceptibility Genes in ACI/Seg Rats: A Model for Prostate Cancers in the Aged (2023)

&lt;div&gt;Abstract&lt;p&gt;ACI/Seg (ACI) rats develop prostate cancers spontaneously with aging, similar to humans. Here, to identify genes involved in prostate cancer susceptibility, we did linkage analysis and oligonucleotide microarray analysis. Linkage analysis was done using 118 effective rats, and &lt;i&gt;prostate cancer susceptibility 1&lt;/i&gt; (&lt;i&gt;Pcs1&lt;/i&gt;), whose ACI allele dominantly induced prostate cancers, was mapped on chromosome 19 [logarithm of odds (LOD) score of 5.0]. &lt;i&gt;PC resistance 1&lt;/i&gt; (&lt;i&gt;Pcr1&lt;/i&gt;), whose ACI allele dominantly and paradoxically suppressed the size of prostate cancers, was mapped on chromosome 2 (LOD score of 5.0). When linkage analysis was done in 51 rats with single or no macroscopic testicular tumors, which had larger prostates and higher testosterone levels than those with bilateral testicular tumors, &lt;i&gt;Pcs2&lt;/i&gt; and &lt;i&gt;Pcr2&lt;/i&gt; were mapped on chromosomes 20 and 1, respectively. By oligonucleotide microarray analysis with 8,800 probe sets and confirmation by quantitative reverse transcription-PCR, only two genes within these four loci were found to be differentially expressed &gt;1.8-fold. &lt;i&gt;Membrane metalloendopeptidase&lt;/i&gt; (&lt;i&gt;Mme&lt;/i&gt;), known to inhibit androgen-independent growth of prostate cancers, on &lt;i&gt;Pcr1&lt;/i&gt; was expressed 2.0- to 5.5-fold higher in the ACI prostate, in accordance with its paradoxical effect. &lt;i&gt;Cdkn1a&lt;/i&gt; on &lt;i&gt;Pcs2&lt;/i&gt; was expressed 1.5- to 4.5-fold lower in the ACI prostate. Additionally, genes responsible for testicular tumors and unilateral renal agenesis were mapped on chromosomes 11 and 14, respectively. These results showed that prostate cancer susceptibility of ACI rats involves at least four loci, and suggested &lt;i&gt;Mme&lt;/i&gt; and &lt;i&gt;Cdkn1a&lt;/i&gt; as candidates for &lt;i&gt;Pcr1&lt;/i&gt; and &lt;i&gt;Pcs2&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A computational framework for predicting laminar reactive flows with soot formation (2010)

Numerical modeling is an attractive option for cost-effective development of new high-efficiency, soot-free combustion devices. However, the inherent complexities of hydrocarbon combustion require that combustion models rely heavily on engineering approximations to remain computationally tractable. More efficient numerical algorithms for reacting flows are needed so that more realistic physics models can be used to provide quantitative soot predictions. A new, highly-scalable combustion modeling tool has been developed specifically for use on large multiprocessor computer architectures. The tool is capable of capturing complex processes such as detailed chemistry, molecular transport, radiation, and soot formation/destruction in laminar diffusion flames. The proposed algorithm represents the current state of the art in combustion modeling, making use of a second-order accurate finite-volume scheme and a parallel adaptive mesh refinement (AMR) algorithm on body-fitted, multiblock meshes. Radiation is modeled using the discrete ordinates method (DOM) to solve the radiative transfer equation and the statistical narrow-band correlated-k (SNBCK) method to quantify gas band absorption. At present, a semi-empirical model is used to predict the nucleation, growth, and oxidation of soot particles. The framework is applied to two laminar coflow diffusion flames which were previously studied numerically and experimentally. Both a weakly-sooting methane–air flame and a heavily-sooting ethylene–air flame are considered for validation purposes. Numerical predictions for these flames are verified with published experimental results and the parallel performance of the algorithm analyzed. The effects of grid resolution and gas-phase reaction mechanism on the overall flame solutions were also assessed. Reasonable agreement with experimental measurements was obtained for both flames for predictions of flame height, temperature and soot volume fraction. Overall, the algorithm displayed excellent strong scaling performance by achieving a parallel efficiency of 70% on 384 processors. The proposed algorithm proved to be a robust, highly-scalable solution method for sooting laminar flames.
Windshear Recovery Using Fuzzy Logic Guidance and Control (1999)

Many aircraft accidents are related to hazardous windshear phenomena, in particular to the microburst. The energy loss which is associated with a microburst encounter can be very dangerous for the aircraft at low altitude. In this paper, a recovery concept is introduced, making a distinction between control, guidance, and flight envelope protection. For control, a fuzzy logic controller is developed based on energy principles, since the windshear is basically an energy problem. Additional energy is automatically supplied during the microburst by increasing the thrust. The available energy is distributed between altitude and airspeed by pitch angle according to a priority assignment, activated at the encounter of the windshear. This priority is determined with respect to a minimum airspeed and altitude, the flight envelope protection mechanism. Both controller and protection are integrated in one fuzzy logic system. Once the flight bounds are guaranteed, the controller tracks the flight path indicated by a predetermined guidance strategy. The application of the concept is demonstrated by a realistic simulation example.
Effects of MEG-based neurofeedback for hand rehabilitation after tetraplegia: preliminary findings in cortical modulations and grip strength (2020)

This study demonstrates that MEG-based NF training can change brain activity in individuals with hand impairment due to SCI and has the potential to induce acute changes in grip strength. Future studies will evaluate whether neuroplasticity induced with long term NF can improve hand function for those with moderate impairment.
Constant quality rate control for streaming MPEG-4 FGS video (2003)

This paper presents a constant quality video rate control (CQVRC) scheme for MPEG-4 FGS (fine-grain scalability) video. The proposed scheme can mitigate quality variations among consecutive frames during the period when there is significant change in the video source or the transmission bandwidth. CQVRC utilizes both non-scalable base layer (BL) and scalable enhancement layer (EL) of MPEG-4 for smoother video quality. To take advantage of the relaxed delay requirement of streaming video, CQVRC for BL exploits a larger decoder buffer, future frame information, and temporal scene segmentation. CQVRC for EL is achieved by embedding one rate-distortion (R-D) pair in each bitplane to construct a piecewise linear R-D model. Experiment results show higher than 1 dB PSNR gain and smaller PSNR variation by comparing the proposed CQVRC with current MPEG-4 FGS VM approach, where BL is encoded with MPEG-4 VM rate control and uniform bit allocation is applied to EL.
Domain action classification using a maximum entropy model in a schedule management domain (2008)

To generate correct reactions, a dialogue system should identify domain actions indicated by users' utterances because speaker intentions can be captured by the domain actions. In this paper, we propose a domain action classification model to determi
Modulation of Erythrocyte Membrane Mechanical Function by β-Spectrin Phosphorylation and Dephosphorylation (1995)

The mechanical properties of human erythrocyte membrane are largely regulated by submembranous protein skeleton whose principal components are alpha- and beta-spectrin, actin, protein 4.1, adducin, and dematin. All of these proteins, except for actin, are phosphorylated by various kinases present in the erythrocyte. In vitro studies with purified skeletal proteins and various kinases has shown that while phosphorylation of these proteins can modify some of the binary and ternary protein interactions, it has no effect on certain other interactions between these proteins. Most importantly, at present there is no direct evidence that phosphorylation of skeletal protein(s) alters the function of the intact membrane. To explore this critical issue, we have developed experimental strategies to determine the functional consequences of phosphorylation of beta-spectrin on mechanical properties of intact erythrocyte membrane. We have been able to document that membrane mechanical stability is exquisitely regulated by phosphorylation of beta-spectrin by membrane-bound casein kinase I. Increased phosphorylation of beta-spectrin decreases membrane mechanical stability while decreased phosphorylation increases membrane mechanical stability. Our data for the first time demonstrate that phosphorylation of a skeletal protein in situ can modulate physiological function of native erythrocyte membrane.
Tonometry in question: can visual screening tests play a more decisive role in glaucoma diagnosis and management? (1989)

Chronic open-angle glaucoma is a disease in which characteristic changes occur in optic nerve morphology and in ganglion cell function. The utility of intraocular pressure readings in the diagnosis and ongoing management of glaucoma patients is pragmatically considered in the light of the availability of potentially more sensitive means of glaucoma monitoring. Conservative appraisal of the literature suggests that traditional clinical tonometry has low diagnostic sensitivity and specificity. The majority of new cases of glaucomatous visual field loss are most likely to arise from the normotensive population. Clinical studies to determine the correlation between intraocular pressure reduction and the preservation of visual function have repeatedly yielded a much weaker association between these two variables than is perhaps generally assumed. Newer psychophysical methods may have greater potential for rapidly identifying and subsequently monitoring glaucoma patients, but still require refinement and more widespread clinical evaluation. One prerequisite for the eventual adoption of such methods is that clinicians fully appreciate the limitations inherent in tonometry as a glaucoma screening and monitoring technique.
WTFHE: neural-netWork-ready Torus Fully Homomorphic Encryption (2020)

We are currently witnessing two arising trends, which have a huge potential to threaten our privacy: the invasive sensors of the Internet of Things (IoT), and the powerful data mining techniques, in particular we focus on Neural Networks (NN's). For this reason, powerful countermeasures must be called for service: namely end-to-end encryption. Such an approach however requires an encryption scheme that enables processing of the encrypted data - this is known as the Fully Homomorphic Encryption (FHE). In this paper, we revisit an FHE scheme named TFHE, which is suitable for evaluation of NN's over encrypted input data, and we suggest to incorporate a verifiability feature to the evaluation process. Since there already exist other variants of the original TFHE scheme-currently only implemented in C++, which is rigid-we further introduce a library for rapid prototyping of new concepts related to TFHE. Our library is implemented in Ruby, which is an interpreted language and which goes with an interactive shell. Hence any new method can be speedily verified before implemented as a high-performance library.
Describing Video With Attention-Based Bidirectional LSTM (2018)

Video captioning has been attracting broad research attention in the multimedia community. However, most existing approaches heavily rely on static visual information or partially capture the local temporal knowledge (e.g., within 16 frames), thus hardly describing motions accurately from a global view. In this paper, we propose a novel video captioning framework, which integrates bidirectional long-short term memory (BiLSTM) and a soft attention mechanism to generate better global representations for videos as well as enhance the recognition of lasting motions in videos. To generate video captions, we exploit another long-short term memory as a decoder to fully explore global contextual information. The benefits of our proposed method are two fold: 1) the BiLSTM structure comprehensively preserves global temporal and visual information and 2) the soft attention mechanism enables a language decoder to recognize and focus on principle targets from the complex content. We verify the effectiveness of our proposed video captioning framework on two widely used benchmarks, that is, microsoft video description corpus and MSR-video to text, and the experimental results demonstrate the superiority of the proposed approach compared to several state-of-the-art methods.
An efficient buyer-seller watermarking protocol based on composite signal representation (2009)

Buyer-seller watermarking protocols integrate watermarking techniques with cryptography, for copyright protection, piracy tracing, and privacy protection. In this paper, we propose an efficient buyer-seller watermarking protocol based on homomorphic public-key cryptosystem and composite signal representation in the encrypted domain. A recently proposed composite signal representation allows us to reduce both the computational overhead and the large communication bandwidth which are due to the use of homomorphic public-key encryption schemes. Both complexity analysis and simulation results confirm the efficiency of the proposed solution, suggesting that this technique can be successfully used in practical applications.
Coal pyrolysis at high temperature (1981)

A recently developed pyrolysis model to simulate coal pyrolysis in a heated grid has been applied to the high temperature rapid pyrolysis of coal in an entrained flow reactor. The model relates evolved products to the coal structure. The results of the model are extended by actual experimental data to temperatures up to 1470/sup 0/C and higher pyrolysis rates. The pyrolysis gas compositions were determined, and the chars were analyzed by Fourier Transform Infrared (FTIR) analysis, elemental analysis and optical microscopy to determine the changes in char chemistry and physical appearance. Major adjustments to the model were made in the aromatic hydrogen and CO-tight kinetic rates at the high temperatures so that a fit could still be obtained to the heated grid data. Minor adjustments were made for reaction kinetics for aliphatics, tar, hydroxyl, CO-loose, N-loose, and carboxyl to retain fit, and rates with the greatest uncertainty are those for the production of olefins, acetylene, and soot for which either no adjustments to the model were made of for which no data are currently available. (BLM)
ChemInform Abstract: Absolute Configuration of Spicamycin, an Antitumor Antibiotic Produced by Streptomyces alanosinicus (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erasable Ink: Full Color Light Responsive Diarylethene Inks for Reusable Paper (Adv. Funct. Mater. 29/2016) (2016)

On page 5230, J.-M. Kim and co-workers report a new type of light-responsive erasable ink. Light-stimulated (UV-vis), color-switchable diarylethenes serve as cyan, magenta and yellow colored ink materials for a full color ink-jet printing system based on the “write-erase-write” concept, thereby utilizing the same paper multiple times. The system opens a new avenue toward erasable ink that is compatible with common office inkjet pinrters.
Safety of hydrogen/natural gas mixtures by pipelines : ANR french project HYDROMEL (2011)

International audience
Optimal scalar quantization of the PARCOR coefficients for speech coding (2003)

The optimal scalar quantization of the PARCOR coefficients and of the log area ratios (LARs) for speech coding is treated. The kernel method to obtain the probability density function of the LARs, and the quantization tables for each coefficient is then computed with the Lloyd-Max algorithm. The optimum bit allocation is performed by the Fox-Makhoul procedure on the LARs and on the decorrelated LARs. The quantization tables of the LARs and the decorrelated LARs are given for 32 bits, using a code-excited linear predictive coder.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Determining the Rotational Alignment of the Femoral Component in Total Knee Arthroplasty Using the Epicondylar Axis (1993)

The posterior condylar surfaces of the femur are routinely used as the reference for the rotational orientation of the femoral component during most primary total knee arthroplasties. The purpose of this investigation was to identify a clearly discernible, reproducible secondary anatomic axis useful for determining the rotational orientation of the femoral component when the posterior condylar surfaces cannot be used. Seventy-five embalmed anatomic specimen femurs were studied. A surgical epicondylar axis was defined as the line connecting the lateral epicondylar prominence and the medial sulcus of the medial epicondyle. The posterior condylar angle was measured as the angle between the posterior condylar surfaces and the surgical epicondylar axis. Measurement of the posterior condylar angle referenced from the surgical epicondylar axis yielded a mean posterior condylar angle of 3.5 degrees (+/- 1.2 degrees) of internal rotation for males and a mean posterior condylar angle of 0.3 degree (+/- 1.2 degrees) of internal rotation for females. Thus, rotational alignment of the femoral component can be accurately estimated using the posterior condylar angle. The posterior condylar angle, referenced from the surgical epicondylar axis, provides a visual rotational alignment check during primary arthroplasty and may improve alignment of the femoral component at revision.
Fetal parathyroids are not required to maintain placental calcium transport (2001)

We used Hoxa3 knockout mice and other mouse models to study the role of the fetal parathyroids in fetal calcium homeostasis. Hoxa3-null fetuses lack parathyroid glands, and absence of parathyroid hormone (PTH) was confirmed with a rodent PTH immunoradiometric assay. The ionized calcium level of Hoxa3-null fetuses was significantly lower than that of wild-type or heterozygous littermates or of the mother. Both the rate of placental calcium transfer and the plasma PTHrP level were normal in Hoxa3 mutants and their heterozygous siblings. Because we had previously observed an increase in placental calcium transfer in PTH/PTHrP receptor 1-null (Pthr1-null) fetuses, we assayed plasma PTHrP in those mice. Pthr1-null fetuses had plasma PTHrP levels 11-fold higher than those of their littermates. Northern analysis, immunohistochemical, and in situ hybridization studies of Pthr1-null fetuses indicated that liver and placenta had increased expression of PTHRP: In summary, loss of fetal parathyroids in Hoxa3-null fetuses caused marked hypocalcemia but did not alter placental calcium transfer or the circulating PTHrP level. The findings in the Pthr1-null fetuses indicate that several tissues may contribute to the circulating PTHrP level in fetal mice.
Wearable Band Using a Fabric-Based Sensor for Exercise ECG Monitoring (2006)

Recently, smart textiles, especially for wearable garments that capable of recording vital signals, have attracted a lot of attention. There are many reports about wearable garment-based platforms focusing on the monitoring of ECG, but most of them are for static situation. In this paper, we report a fabric-based garment sensing system to monitor the exercise electrocardiogram (ECG); a wireless communication configuration based on Bluetooth to transfer the signals into a PDA; and an algorithm to retrieve the desired ECG signals from the raw data. In addition, PDA can communicate with a remote server by WiFi to insure that all data could be stored exactly. The experimental results in resting, walking, or jogging, show this wearable garment system can steadily, continuously and precisely get the ECG, RRI and HRV.
Development of Centralized Voltage Control System for Distribution Systems (2013)

This paper proposes a centralized voltage control system for distribution system to meet the impact of PV growth. The system consists of a server machine at control center and many field devices like voltage regulators, line switches with sensor to measure power flow and voltage, and Information and Communication Technologies (ICT) network under Smart Grid paradigm. The system gathers measurement values from switches through the ICT network and chooses the best voltage profile and voltage regulators condition to achieve the profile with use of our advanced Optimal Power Flow. The test results at our Smart Grid facilities with 4MW photovoltaic generators are also given to prove the effectiveness of the developed system.
Applications (1993)

The commercial exploitation of MMCs is now becoming significant. A number of applications have emerged in which their advantages over traditional materials are such that full-scale substitution is now taking place. In other instances more detailed engineering data are needed and/or manufacturing or design problems need to be resolved. In surveying the scope for commercial usage, it should be recognised that in many cases it is the potential for achieving a desirable suite of properties which makes MMCs so attractive. Nevertheless, it is helpful to examine the potential advantages in turn, and this is done in the first part of the current chapter, with illustrative examples of usage mentioned where appropriate. In the second part, attention is concentrated on several specific applications for which MMCs are either already in use or are undergoing commercialisation.
Differences in optimal timing of post-surgical surveillance for limited stage lung cancer patients and associations with outcomes (2019)

Background: Guidelines for post-operative surveillance for non-small cell lung cancer (NSCLC) are variable. Historically, providers have used a one-size fits all approach, such that surveillance guidelines incorporated few important prognostic indicators for recurrence and survival. The goal of this study was to determine optimal timing for detection of recurrence by CT scan and the association between surveillance CT and overall survival. Methods: This was a retrospective, single institution series of patients undergoing surgical resection [2008–2012] with stage I or II disease (AJCC 7th edition) with at least 6 months of follow-up. Results: Recurrence occurred in 27.2% of patients at a median of 29.5 months following surgery. Recurrences peaked at 2–3 years following surgery for the entire cohort. For those detected on CT scan surveillance, stage I the peak timing for recurrence was at 25–36 months (year 3) whereas stage II peak timing was at 19–24 months (year 2) following resection. Timing of recurrences detected by any means differed significantly based on cancer stage with 81% (n=27) of recurrences occurring more than 24 months following surgery for stage I patients compared to 41% (n=17) of stage II patients (P<0.01). Overall, higher rates of surveillance CT scans were associated with a reduced risk of death [HR 0.14 (95% CI, 0.06–0.36) P<0.01]. Conclusions: The timing of recurrence differs significantly based on stage such that few stage I patients have recurrences within 2 years following surgical resection. Additionally, rates of recurrence detected by surveillance CT scans performed less than 24 months following surgery is significantly lower for stage I patients compared to stage 2 which would favor delaying routine surveillance in this select group. Optimal timing of CT surveillance based on peak recurrence rates has the potential to eliminate unnecessary testing and expense for healthcare systems.