gebhart/patrepeval huggingface dataset:
“Brush-like” Amphiphilic Polymer for Environmental Adaptive Coating (2022)

Multiple functional coating is urgently needed in complex service surroundings to meet various requirements. In this work, a brush-like amphiphilic copolymer of poly methacryloxyethyl dimethyl butyl ammonium bromide-polydimethylsiloxane (pMDBAB-PDMS) was synthesized to construct an environment-adaptive multifunctional coating based on the copolymer via the UV-curing method. The special molecule chains of the copolymer assembled predominately on the coating surface in different surroundings, which rendered the surface with various functions. In water-rich surroundings, the hydrophilic quaternary ammonium groups in the coating endow the coating surface with antifogging, oleophobicity underwater, self-cleaning, antibacteria, triboelectric resistance, and super lubrication properties. In dry air surroundings, the long, flexible, low surface energy molecular PDMS chains tend to distribute on the top of the coating surface, which gives a low friction coefficient and antioil properties. This work presents a strategy to construct environmental adaptive coating that has an important application prospect in the field of optical lens.
Sequencing of PRKAG1 coding sequence and mapping of PRKAG1 and PRKAG2 relatively to porcine back fat thickness QTL (2003)

12 ref. *INRA Génétique cellulaire 31326 Castanet-Tolosan (FRA) Diffusion du document : INRA Génétique cellulaire 31326 Castanet-Tolosan (FRA)
Оптическая когерентная томография в диагностике дисплазии и аденокарциномы пищевода Барретт (2007)

The potential of optical coherence tomography was studied in the diagnosis of dysplasia and adenocarcinoma of the esophagus. This method allows in vivo study of esophageal structures at a resolution 10 to 20 mcm. Statistical analysis of images of 78 patients with Barrett's esophagus was performed. Optical coherence tomography in early diagnosis of Barrett's esophagus demonstrated a 77% sensisitivty, a 85% specificity, a 82% diagnostic accuracy, a positive test prediction value 70%, a negative test prediction value 87%. Optical coherence tomography was most efficient in recognition of esophageal intramucosal adenocarcinoma. In this case the test had a sensitivity 85% and a specificity 85%. Early malignization in Barrett's esophagus often has no endoscopic manifestations, and optical coherence tomography may therefore be a useful endoscopy tool.
The Federal Information Security Management Act of 2002: A Potemkin Village (2011)

Due to the daunting possibilities of cyberwarfare, and the ease with which cyberattacks may be conducted, the United Nations has warned that the next world war could be initiated through worldwide cyberattacks between countries. In response to the growing threat of cyberwarfare and the increasing importance of information security, Congress passed the Federal Information Security Management Act of 2002 (FISMA). FISMA recognizes the importance of information security to the national economic and security interests of the United States. However, this Note argues that FISMA has failed to significantly bolster information security, primarily because FISMA treats information security as a technological problem and not an economic problem. This Note analyzes existing proposals to incentivize heightened software quality assurance, and proposes a new solution designed to strengthen federal information security in light of the failings of FISMA and the trappings of Congress’s 2001 amendment to the Computer Fraud and Abuse Act.
Supplementary Figure 7 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer (2023)

&lt;p&gt;PDF file - 504K, Response of xenografts of human prostate cancer specimens to IGF-1R inhibition as a function of NRP2 expression&lt;/p&gt;
Development of a new battery system for hybrid vehicles (2000)

The new battery system which was developed for the Toyota Prius was described. The Toyota Prius was the first mass-produced hybrid electric-powered vehicle on the global market. It was introduced in 1997, demonstrating excellent fuel economy compared to gasoline vehicles. To date, more than 30,000 Prius cars have been sold world-wide. The battery has a rectangular module with six cells linked in series. Because of its' simple structure, where the modules are placed side by side, its overall size and weight are significantly reduced by 60 and 30 per cent respectively. To ensure heat dissipation, the module is thin with a wide surface area. The battery case is composed of plastic which is resistant to the alkaline electrolyte, electrical insulation between cells, formability of the modular shape and weight. The configuration of the new battery means that minimum amount of space is needed for cooling. Future efforts will concentrate on reducing the cost of the battery to facilitate its commercialization. figs.
Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis (2012)

Rheumatoid arthritis is a systemic autoinmmune disease mediated by T cells. Productive engagement of T cell receptors by major histocompatibility complex-peptide leads to proliferation, differentiation and the definition of effector functions. Altered peptide ligands (APL) generated by amino acid substitutions in the antigenic peptide have diverse effects on T cell response. We predicted a novel T cell epitope from human heat-shock protein 60, an autoantigen involved in the pathogenesis of rheumatoid arthritis. Three APLs were designed from this epitope and it was demostrated that these peptides induce the activation of T cells through their ability to modify cell cycle phase's distribution of CD4+T cells from RA patients. Also, IL-17, TNF-α and IL-10 levels were determined in PBMC from these patients. Unlike the wild-type peptide and the other two APLs, APL2 increased the IL-10 level and suppressed IL-17 secretion in these assays. Therapeutic effect of this APL in adjuvant arthritis (AA) and collagen-induced arthritis (CIA) models was also evaluated. Clinical score, histopathology, inflammatory and regulatory cytokine concentration were monitored in the animals. APL2 efficiently inhibited the progression of AA and CIA with a significant reduction of the clinical and histopathogic score. Therapeutic effect of APL2 on CIA was similar to that obtained with MTX; the standard treatment for RA. This effect was associated with a decrease of TNF-α and IL-17 levels. These results suggest that the therapeutic effect of APL2 is mediated in part by down-regulation of inflammatory cytokines and support the potential use of APL2 as a therapeutic drug in RA patients.
A natural component as coinitiator for unfilled dental resin composites (2007)

A natural component, 1,3-benzodioxole (BDO), was used for the purpose of replacing the conventional amine for dental composite. Camphorquinone (CQ)/BDO was used to initiate the photopolymerization of urethane dimethacrylate (UDMA)/triethylene glycol dimethacrylate (TEGDMA) (70/30 wt %). The kinetics was recorded by real-time Fourier transformation infrared spectroscopy (FTIR). The mechanical properties were measured by dynamic mechanical analyzer (DMA), and CQ/ethyl 4-N,N-dimethylaminobenzoate (EDMAB) mixture was used as control in the same photocuring condition. The results indicated that, the addition of BDO as coinitiator greatly improved the rate of polymerization and final double bond conversion (DC), when compared with the system initiated by CQ alone. BDO and EDMAB were found to reach almost the same final DC (75%), though the kinetics of two systems was different. Comparing with EDMAB, BDO brought approximately the same glass transition temperature (Tg), but slightly higher storage modulus around 37 degrees C. The water sorption and solubility for two mixtures were almost the same and within the range of the ISO 4049's standards. These results suggested that BDO was an effective alternative to conventional amine for coinitiator. And the human diet characteristics of BDO made it more promising than amine in the dental resin formulations.
RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia (2022)

Despite recent advances in acute myeloid leukemia (AML) molecular characterization and targeted therapies, a majority of AML cases still lack therapeutically actionable targets. In 127 AML cases with unmet therapeutic needs, as defined by the exclusion of ELN favorable cases and of FLT3-ITD mutations, we identified 51 (40%) cases with alterations in RAS pathway genes (RAS+, mostly NF1, NRAS, KRAS, and PTPN11 genes). In 79 homogeneously treated AML patients from this cohort, RAS+ status were associated with higher white blood cell count, higher LDH, and reduced survival. In AML models of oncogenic addiction to RAS-MEK signaling, the MEK inhibitor trametinib demonstrated antileukemic activity in vitro and in vivo. However, the efficacy of trametinib was heterogeneous in ex vivo cultures of primary RAS+ AML patient specimens. From repurposing drug screens in RAS-activated AML cells, we identified pyrvinium pamoate, an anti-helminthic agent efficiently inhibiting the growth of RAS+ primary AML cells ex vivo, preferentially in trametinib-resistant PTPN11- or KRAS-mutated samples. Metabolic and genetic complementarity between trametinib and pyrvinium pamoate translated into anti-AML synergy in vitro. Moreover, this combination inhibited the propagation of RA+ AML cells in vivo in mice, indicating a potential for future clinical development of this strategy in AML.
Characteristics of Nafion Membranes with Pd Thin Films Deposited by DC Magnetron Sputtering Technique (2002)

상용 고분자 전해질인 Nafion 115 및 Nafion 117막 위에 do magnetron sputtering방법으로 Pd박막을 다양한 두께로 증착한 다음, 개질된 고분자 전해질 막의 morphology, proton 전도도(conductivity), 메탄을 투과도(permeability)를 측정하였으며, membrane and electrode assemblies(MEA)를 구성하여 DMFC 단위전지 성능을 측정하였다. Pd 박막은 Nafion막이 지니고 있는 단점인 메탄을 crossover에 대한 barrier로서 작용하였지만, 동시에 Nafion막의 고유 특성인 proton전도도의 감소를 가져왔다. Pd박막에 의하여 개질된 Nafion막의 메탄올에 대한 투과도와 proton전도도는 Nafion 막 상에 증착된 Pd 박막의 두께가 증가할수록 직선적으로 감소하는 경향을 나타냈다 개질된 Nafon 막을 사용하여 제작한 direct methanol fuel cell(DMFC)단위전지의 성능은 전체적으로 약간 저하되었다. Modified polymer electrolyte membranes were fabricated by the applying dc magnetron sputter-deposited Pd thin layers on the surface of the <TEX>$Nafion^{TM}$</TEX> membranes in argon atmosphere. The Pd thin films were characterized by investigating its morphology, methanol permeability, and protonic conductivity. The performance of a direct methanol fuel cell(DMFC) with the modifed polymer electrolyte membrane was also tested by the measurement of its currents and voltages under flowing methanol. The Pd thin film could be a barrier layer to methanol crossover, but the protonic conductivity of the modified polymer membrane was reduced. By using the modified polymer eletrolyte membranes, both the methanol permeability and the protonic conductivity were decreased with increasing the thickness of Pd thin film. However, the performances of DMFC were almost independent on the thickness of Pd thim films. The efffcts of methanol concentration in a feeding fuels on the protonic conductivity and the cell performance were also investigated.
Analysis of DNA Regulatory Elements Required for Expression of theLegionella pneumophilaicmanddotVirulence Genes (2002)

To investigate the regulation of the Legionella pneumophila icm and dot genes required for intracellular growth, a series of nine icm::lacZ fusions were constructed. These icm::lacZ fusions were found to have different levels of expression in L. pneumophila, and five of them were more highly expressed at stationary phase than at exponential phase. When the expression of these fusions in Escherichia coli was tested, all of them were found to be expressed but three of them had dramatic changes in their levels of expression in comparison to those in L. pneumophila. Site-directed and PCR random mutagenesis with these icm::lacZ fusions was used to identify DNA regulatory elements of icm genes. Four icm genes (icmT, icmP, icmQ, and icmM) that had low levels of expression in L. pneumophila were found to contain a 6-bp sequence (TATACT) essential for their expression. This sequence was shown by primer extension to serve as their -10 promoter elements. A similar sequence, which constitutes the -10 promoter elements of the icmV, icmW, and icmR genes which had high levels of expression in L. pneumophila, was also identified. In addition, regulatory elements that probably serve as binding sites for transcription regulators were found in these genes. Altogether, 12 regulatory elements, 7 of which constitute the -10 promoter elements of the icm genes, were found. Even though all the icm and dot genes are part of one system required for L. pneumophila intracellular growth and even though their promoters are probably recognized by the vegetative sigma factor, it seems that they are subjected to different regulation mediated by several regulatory factors.
Measurement of plasma volume in rats with use of fluorescent-labeled albumin molecules (1994)

We describe a method for measuring plasma volume (PV) in small animals that allows small sample sizes but does not require the use of radioisotopes and thus is a convenient approach for making repeated measurements. Texas Red covalently bound to albumin (TR-A) was used in a typical indicator-dilution technique to measure PV. The relative fluorescent intensity of TR-A is linear to its concentration (up to 0.15 mg/ml) at an excitation lambda of 590 nm and an emission lambda of 610 nm. Catheters were inserted through the right jugular vein of anesthetized rats and threaded into the vena cava. A 0.5-ml control blood sample was taken, a measured quantity of TR-A was injected, and the catheter was flushed with saline. A 0.5-ml postinjection sample was taken 5 min after TR-A injection. PV was calculated by comparing the difference between the relative fluorescent intensity of control and postinjection plasma samples to a standard. The PV of 22 rats [362 +/- 14 (SE) g] was 14.1 +/- 0.4 ml (39.6 +/- 0.9 ml/kg body wt) measured by the TR-A method and 12.8 +/- 0.4 ml (35.9 +/- 1.0 ml/kg body wt) measured by a standard radioiodinated albumin method. There was a strong correlation between PV measured by both methods in the same rat (r = 0.90, P < 0.01). Infusion experiments indicated that the TR-A method can detect acute changes in PV, and repeated measurements of PV made on a chronically instrumented rat demonstrated that the method can reliably measure PV on consecutive days.
Computational Imaging for Dynamic Metasurface based Synthetic Aperture Radars (2017)

Thesis (Master's)--University of Washington, 2017-06
Changes in choline acetyltransferase activity of rat tissues during Chagas' disease. (1987)

1. The activity of choline acetyltransferase (CAT) measured by a radiolabeling method was significantly reduced in the heart, submandibular gland and esophagus of rats 20 days after inoculation with Trypanosoma cruzi (Y strain). 2. Normal enzyme activity was recovered in all these organs 100 days after inoculation. 3. In the transverse colon, no change, 30% reduction and normal activity were found at days 20, 100 and 430 of infection, respectively. 4. The data indicate recovery of parasympathetic function in experimental Chagas' disease. Axonal regrowth and sprouting are discussed as possible candidates for the recovery mechanisms.
Is External Carotid Artery Hemodynamics Helpful in Detecting Internal Carotid Artery Stenosis? (2022)

Introduction: There is a paucity of validated external carotid artery (ECA) velocity criteria and data on the association between ECA velocities and internal carotid artery (ICA) stenosis by carotid duplex ultrasound (CDU) scanning. Our objectives were to determine the relationships between ECA peak systolic velocity (PSV) and percent stenosis seen on confirmatory imaging, as well as to correlate ECA hemodynamics with known ICA disease by CDU. Methods: A retrospective chart review was performed for patients who had CDU, as well as confirmatory testing such as angiography, at a single academic medical center. ICA stenosis was grouped into 4 categories (0 = &lt;50%, 1 = 50%-69%, 2 = 70%-99%, 3 = 100%) based on validated CDU criteria. ECA PSVs were analyzed, in addition to degree of both ECA and ICA stenosis from the same CDU study. Results: Of 247 carotid arteries reviewed, 136 vessels were included in the final analysis. The mean PSV of the normal ECA cohort (&lt;50% ECA stenosis per the NASCET measurement method) was 135.3 ± 82.1 cm/s, and the mean PSV of the diseased ECA cohort was 279.7 ± 112.2 cm/s. Mean ECA PSV for each category of ICA stenosis was: ICA category 0 = 119.9 cm/s; category 1 = 200.4 cm/s; category 2 = 167.7 cm/s; and category 3 = 155.5 cm/s. There was a statistically significant but non-linear difference in ECA velocities between ICA stenosis categories 0 vs 1 (mean rank diff. −49.91 cm/s; P = .0007); and 0 vs 2 (mean rank diff. −32.61 cm/s; P = .0047). Conclusion: We have demonstrated a possible separation of &lt;50% vs ≥50% stenosis of the ICA using ECA PSV. Although the data suggest a weak but statistically significant correlation between ECA PSV and degree of ICA stenosis, further data with a larger sample size and confirmatory studies are needed to utilize ECA hemodynamics to indicate ICA disease.
Subclinical cerebrovascular disease inversely associates with learning ability (2015)

White matter hyperintensities, a marker of cerebral small vessel disease, may have an impact on learning slope. This suggests that verbal learning performance can be incorporated into neuropsychological measures for vascular cognitive impairment and that cerebrovascular disease discovered on imaging affects the ability to learn new information.
Red fluorescence of comedones: production of porphyrins by Corynebacterium acnes. (1967)

It has been known since the late 1920's that many individuals show an orange-red fluorescence of the comedones of the face when examined under ultraviolet light (1). This phenomenon is most marked in the comedones of the nose and cheeks. Carrie, in 1934, suggested that this fluorescence might possibly be due to gram positive bacilli residing in the substance of the comedones (2).
Extended Transparent-Scan (2019)

Transparent-scan is an approach to test compaction where scan shift cycles and functional capture cycles are interleaved in arbitrary ways as needed for detecting target faults. This is achieved by viewing the scan enable input as a regular primary input that can be assigned arbitrary sequences of zero and one values. This paper notes that transparent-scan leaves an unused combination of the scan enable and scan chain input values. This paper suggests that the unused combination can control design-for-testability logic to achieve better test compaction. At the cost of one additional EXCLUSIVE-OR gate for every state variable, and routing of the scan chain input to all the flip-flops, the extended transparent-scan approach described in this paper allows the values of the next-state variables to be complemented before they are latched in the flip-flops during a functional capture cycle. Extended transparent-scan is developed under bounded transparent-scan, where scan-in and scan-out operations of a conventional scan-based test set are maintained in order to limit the computational cost. Experimental results for transition faults in the functional logic of benchmark circuits demonstrate the additional test compaction that can be achieved with extended transparent-scan. Transition faults in the scan logic are considered as well.
Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney (2020)

These data reveal novel functions for Pax proteins in adult renal epithelia that are essential for retaining water and concentrating urine.
5-factor prognostic model for survival of patients with metastatic urothelial carcinoma receiving three different post-platinum PD-L1 inhibitors. (2019)

4552 Background: A prognostic model for overall survival (OS) of metastatic urothelial carcinoma (mUC) was previously reported in the setting of post-platinum atezolizumab (Pond GR, GU ASCO 2018). This model was limited by employing only atezolizumab treated patients (pts), small size of the validation dataset and unclear applicability to other PD-1/L1 inhibitors. Hence, we constructed a robust prognostic model utilizing the combined atezolizumab cohort as the discovery dataset and used 2 separate validation datasets comprised of post-platinum avelumab or durvalumab treated pts. Methods: The discovery dataset consisted of pt level data from 2 phase I/II trials (IMvigor210 and PCD4989g) evaluating atezolizumab (n = 405). Pts enrolled on 2 separate phase I/II trials, EMR 100070-001 that evaluated post-platinum avelumab (n = 242) and CD1108 that evaluated durvalumab (n = 189) comprised the validation datasets. Cox regression analyses evaluated the association of candidate prognostic factors with OS. Factors were dichotomized and laboratory values were normalized by logarithmic transformation. Stepwise selection was employed to propose an optimal model using the discovery dataset. Discrimination and calibration were assessed in the avelumab and durvalumab datasets following the validation procedure by Royston and Altman (2013). Results: The 5 factors included in the optimal prognostic model in the discovery dataset were ECOG-PS (1 vs. 0; HR 1.80; 95% CI [1.36-2.36]), presence/absence of liver metastasis (HR 1.55; 95% CI [1.20-2.00]), number of platelets (HR 2.22; 95% CI [1.54-3.18]), neutrophil-lymphocyte ratio (NLR; HR 1.94; 95% CI [1.57-2.40]) and lactate dehydrogenase (LDH; HR 1.60; 95% CI [1.28-1.99]). There was robust discrimination of survival between low, intermediate and high-risk groups based on 0-1, 2-3 and 4 factors. The concordance of survival was 0.692 in the discovery and 0.671 and 0.775 in the avelumab and durvalumab validation datasets, respectively. Acceptable or good calibration of expected 1-year survival rate was observed. Conclusions: A 5-factor prognostic model is prognostic for survival across 3 different PD-L1 inhibitors (atezolizumab, avelumab, durvalumab) in this large study totaling 836 pts overall in the setting of post-platinum therapy for mUC. This model may assist in prognostic stratification and interpreting nonrandomized trials of post-platinum PD1/L1 inhibitors.
Soft Weight-Sharing for Neural Network Compression (2017)

The success of deep learning in numerous application domains created the de- sire to run and train them on mobile devices. This however, conflicts with their computationally, memory and energy intense nature, leading to a growing interest in compression. Recent work by Han et al. (2015a) propose a pipeline that involves retraining, pruning and quantization of neural network weights, obtaining state-of-the-art compression rates. In this paper, we show that competitive compression rates can be achieved by using a version of soft weight-sharing (Nowlan &amp; Hinton, 1992). Our method achieves both quantization and pruning in one simple (re-)training procedure. This point of view also exposes the relation between compression and the minimum description length (MDL) principle.