gebhart/patrepeval huggingface dataset:
In vitro infection of human macrophages with human T-cell leukemia virus type 1 (1993)

The tropism of the human T-cell leukemia virus type 1 (HTLV-1) for the cells of monocyte-macrophage lineage was evaluated by the coculture of blood monocyte-derived macrophages, with irradiated cells of HTLV-1 producing cell lines MT2 or C91/PL. The susceptibility to HTLV-1 was assessed by the detection of viral DNA using the polymerase chain reaction method. HTLV-1 gene expression in the cells was detected using in situ hybridization and by immunofluorescent staining of viral antigen. The presence of type C virus-like particles detected by electron microscopy and the ability to infect normal cord blood lymphocytes demonstrated that the infected macrophages produced infectious virus. These results indicate that human macrophages are susceptible in vitro to productive HTLV-1 infection, and thus might be involved in the pathogenesis of HTLV-1-related diseases.
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. (1988)

The product of the protooncogene c-src is a protein-tyrosine kinase, p60c-src, that is normally inhibited by phosphorylation at a tyrosine residue close to the C terminus (Tyr-527). If activated by dephosphorylation of Tyr-527, or by other means, p60c-src becomes phosphorylated at a tyrosine residue in the catalytic domain (Tyr-416). To test whether either or both of these tyrosines can be phosphorylated by p60c-src itself, we have created four mutations in c-src. One mutant product can receive but cannot donate phosphate, and other mutants are capable of catalysis but lack phosphorylation sites. The mutant genes were expressed singly or in combination in yeast. Analysis of the phosphorylation of mutant p60c-src in the yeast cells and in immunoprecipitates showed that p60c-src molecules can phosphorylate each other at Tyr-416 and -527. Prohibiting intramolecular phosphorylation had little effect on reaction rates and extents, suggesting that intermolecular phosphorylation predominates. If the same situation pertains in the milieu of the vertebrate fibroblast, phosphorylation of one p60c-src by another at Tyr-416 or -527 could permit positive or negative autoregulation.
Dielectric and transport properties of thin films precipitated from sols with silicon nanoparticles (2011)

Dielectric properties of thin films precipitated on solid substrates from colloidal solutions containing silicon nanoparticles (average diameter is 10 nm) are studied by optical ellipsometry and impedance-spectroscopy. In the optical region, the values of real ɛ′ and imaginary ɛ″ components of the complex permittivity ɛ vary within 2.1–1.1 and 0.25–0.75, respectively. These values are significantly lower than those of crystalline silicon. Using numerical simulation within the Bruggeman effective medium approximation, we show that the experimental ɛ′ and ɛ″ spectra can be explained with good accuracy, assuming that the silicon film is a porous medium consisting of silicon monoxide (SiO) and air voids at a void ratio of 0.5. Such behavior of films is mainly caused by the effect of outer shells of silicon nanoparticles interacting with atmospheric oxygen on their dielectric properties. In the frequency range of 10–106 Hz, the experimentally measured ɛ′ and ɛ″ spectra of thin nanoscale silicon films are well approximated by the semi-empirical Cole-Cole dielectric dispersion law with the term related to free electric charges. The experimentally determined power-law frequency dependence of the ac conductivity means that the electrical transport in films is controlled by electric charge hopping through localized states in the unordered medium of outer shells of silicon nanoparticles composing films. It is found that the film conductivity at frequencies of ≤2 × 102 Hz is controlled by proton transport through Si-OH groups on the silicon nanoparticle surface.
NDE: SURFING THE ELECTROMAGNETIC SPECTRUM (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Harry I. Ringermacher; NDE: SURFING THE ELECTROMAGNETIC SPECTRUM. AIP Conf. Proc. 22 February 2010; 1211 (1): 29–46. https://doi.org/10.1063/1.3362408 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Phase II Trial of Carboplatin in Soft-Tissue Sarcoma (1990)

As part of the Eastern Cooperative Oncology Group program for the assessment of new drugs in sarcomas, a Phase II trial of carboplatin was performed in patients who had received no more than one prior chemotherapy regimen. A total of 50 patients received either 400 mg/m2 or 320 mg/m2 depending on whether they had received prior radiotherapy. A response rate of 16% (95% confidence interval 6-32%) occurred in the 37 patients who had received doxorubicin as their only prior systemic therapy. Three of the six responses were complete and persisted for 7 to 34 months. In contrast none of the 13 patients who received carboplatin after initial progression on doxorubicin and subsequent progression on interferon alpha responded. The overall response rate was therefore 12% (95% confidence interval 5-24%). Toxicity was primarily hematologic, with 14 patients having Eastern Cooperative Oncology Group (ECOG) grade 3 toxicity and no grade 4 or 5 toxicities. In view of the number of complete responses, carboplatin should be studied further in untreated patients with advanced soft tissue sarcoma.
A novel efficient cationic flocculant prepared through grafting two monomers onto chitosan induced by Gamma radiation (2011)

Two monomers, acrylamide (AM) and (2-methacryloyloxyethyl) trimethyl ammonium chloride (DMC) were grafted onto chitosan simultaneously in acid-water solution initiated by the highly efficient and environmentally friendly gamma ray radiation at ambient temperatures. The copolymer obtained was analyzed using Fourier-transform infrared, X-ray powder diffraction and thermogravimetric analysis. The cationic degree of the copolymer was determined by the colloid titration method. Its flocculation properties were evaluated in 0.25% (wt) kaolin suspensions and its significant superiority over PAM (polyacrylamide) and chitosan was observed. The results of zeta potential measurement demonstrated that the flocculation mechanism of the copolymer was distinct when it was used as a flocculant under different conditions. The images and the settling rate test of the floccules after treating by the flocculant showed that the capacities of bridging and charge neutralization of the graft copolymer were improved after the grafting of AM and DMC. Jar tests with pulp mill wastewater demonstrated that the flocculation efficiency of the graft copolymer was much better than that of PAM.
Decoding Navigation Data Messages from Weak GPS Signals (2009)

A new method for decoding navigation data bits from very weak Global Positioning System (GPS) signals is presented. Coherent signal integration is applied over a time period that includes multiple navigation data bits. A search is performed for a combination of bits that maximizes the signal energy during the coherent integration.
Development and Customization of a Color-Coded Microbeads-Based Assay for Drug Resistance in HIV-1 Reverse Transcriptase (2014)

We developed a rapid high-throughput assay for clade B HIV-1 DR mutations, which could be customized by synthesizing oligoprobes suitable for the circulating viruses. The assay could be a useful tool especially for public health research in both resource-rich and resource-limited settings.
Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds (2023)

In recent years, photochemistry has increasingly emerged as an enabling methodology in both academia and the pharmaceutical industry. Long photolysis times and the gradual reduction of light penetration remained for many years unsolved issues for photochemical rearrangements, triggering the generation of highly reactive species in an uncontrolled fashion and causing the formation of multiple side products. The emergence of continuous-flow chemistry significantly helped to overcome these issues, thus prompting the implementation of photo-flow-based approaches for the generation of pharmaceutically relevant substructures. This Technology Note highlights the benefits of flow chemistry for photochemical rearrangements, including Wolff, Favorskii, Beckmann, Fries, and Claisen rearrangements. We showcase recent advances for photo-rearrangements in continuous flow applied to the synthesis of privileged scaffolds and active pharmaceutical ingredients.
Coverage and Drift Produced by Air Induction and Conventional Hydraulic Nozzles Used for Orchard Applications (2007)

A conventional, axial-flow, air-blast orchard sprayer was used to make applications to the outside row of a semi-dwarf apple block. Fluorescent tracer was applied at the same rate using either disc-core nozzle sets or air-induction nozzles fitted with flat-fan tips. The experiment included measuring the percent area of spray coverage on leaves after three variations in spray application method. Each of the variations used a different type of nozzle on the same conventional, axial-fan orchard sprayer. The three nozzle variations were a Spraying Systems D3-25 nozzle set, a Spraying Systems D4-25 nozzle set, and a TurboDrop 02 (TD02) air-induction nozzle set. Canopy spray deposits, downwind sedimentation, and airborne spray losses were also measured following treatment on the inside half of the outside row using D4-25 nozzles or TD02 nozzles. The small droplet spectrum D3-25 nozzle set produced the highest leaf surface coverage on both upperside and underside surfaces at 2.0 and 3.0 m heights in the canopy. The upperside leaf surface coverage produced by the D3-25 nozzle was only somewhat greater than the TD02 nozzle. It was, however, significantly higher than the D4-25 nozzle set at the 3.0 m height. Conversely, the underside leaf surface coverage produced by the D3-25 was significantly greater than the TD02 nozzle set at both 2.0 and 3.0 m heights and not statistically different from the D4-25 nozzle set at the lower sampling height. There were relatively few differences in canopy spray deposits between the D4-25 and TD02 nozzle sets. The TD02 treatment produced the lowest downwind sedimentation deposits on targets 8 to 32 m from the edge of the orchard. The D4-25 produced approximately three times higher deposits up to 9 m above the ground than the TD02 treatment on passive nylon screens located 8 m downwind from the edge of the orchard. The D4-25 treatment produced significantly higher airborne deposits on elevated, high-volume, air sampler filters out to 64 m. At 128 m, sedimentation and airborne deposits were similar for the D4-25 and TD02 treatments.
A Case with an Acoustic Trauma After Air-bag Deployment. (2002)

近年エアバッグの普及に伴い, 交通事故時の安全性は向上したものの, 一方で副傷害の報告もなされている。 今回われわれは, エアバッグ作動に伴う強大音により, 音響外傷をきたしたと考えられる急性感音難聴例を経験した。 症例は64歳男性で左難聴, 耳鳴を主訴に当科を受診した。 純音聴力検査では, 谷型の中等度感音難聴を示した。 ABLBテスト, 歪成分耳音響放射, 蝸電図, ABRを施行し, 聴覚障害部位は蝸牛と考えられた。 突発性難聴に準じ, 副腎皮質ホルモンを中心の薬物療法を行ったが, 受傷半年後も左聴力低下は不変であった。 交通外傷時の聴力障害の原因として, エアバッグの作動時の強大音により音響外傷が生じうることを念頭に置く必要がある。
Limitations of the hematocrit level to assess the need for red blood cell transfusion in hypovolemic anemic patients (2006)

The Hct values in hypovolemic anemic patients are elevated because the plasma volume does not increase to achieve the normovolemic anemic state.
Solid-salt pressure-retarded osmosis with exothermic dissolution energy for sustainable electricity production (2015)

Salinity gradient power (SGP) systems have strong potential to generate sustainable clean electricity for 24 hours. Here, we introduce a solid-salt pressure-retarded osmosis (PRO) system using crystal salt powders rather than seawater. Solid salts have advantages such as a small storage volume, controllable solubility, high Gibbs dissolution energy, and a single type of water intake, low pretreatment costs. The power densities with 3 M draw solutions were 11 W/m<sup>2</sup> with exothermic energy and 8.9 W/m<sup>2</sup> without at 35 bar using a HTI FO membrane (water permeability <i>A</i> = 0.375 L m<sup>-2</sup> h<sup>-1</sup> bar<sup>-1</sup>). These empirical power densities are ~13% of the theoretical value.
Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats (1989)

Platelet-activating factor (PAF) may be involved in the pathophysiology of gastrointestinal damage and motility changes. The effects of PAF in inducing gastric contractions in vivo have now been determined in pentobarbital sodium-anesthetized rats. Local intra-arterial infusion of PAF (5-50 ng.kg-1.min-1 for 10 min) induced a maintained rise in intragastric pressure followed by a further postinfusion increase. Inhibitors of eicosanoid biosynthesis had no effect on these gastric motility changes. However, pretreatment with cimetidine or methysergide decreased by 50% the initial increase in intragastric pressure, whereas mepyramine, adrenergic alpha- and beta-receptor blockade, atropine, hexamethonium, or vagotomy had no effect. During the local infusion of tetrodotoxin, the initial increase in intragastric pressure was not maintained, and the postinfusion increase was abolished. With these inhibitors and antagonists, there was no consistent correlation between the extent of PAF-induced mucosal damage and increase in intragastric pressure. Tetrodotoxin had no effect on the changes in intragastric pressure induced by the thromboxane mimetic U-46619. Administration of Escherichia coli and Salmonella typhosa endotoxin (50 mg/kg iv) also increased intragastric pressure, which peaked after 10 min and slowly declined thereafter. These effects were inhibited by the specific PAF-receptor antagonist L652,731, suggesting that the endogenous release of PAF may contribute to the endotoxin-induced increases in gastric motility. The present study suggests that PAF initially acts directly on smooth muscle and through histamine and serotonin release with a secondary motility response due to activation of nonadrenergic noncholinergic, neuronal activity.
Effect of Extracts from Acanthopanax senticosus and Eucommia ulmoides on Shelf-Life and Quality of Wet Noodle (2010)

1.5% 농도의 가시오가피와 두충 추출 혼합물 첨가가 생면의 저장성과 품질에 미치는 영향에 대하여 알아보았다. 가시오가피와 두충 추출 혼합물을 첨가한 생면을 4℃에서 21일간 저장하며 일반 세균수와 곰팡이수를 측정한 결과, 저장기간 전반에 걸쳐서 처리구가 무처리구보다 미생물의 생육이 억제되었다. 산화도의 경우 처리구가 무처리구보다 낮은 값을 보여 추출물에 의해 생면의 산화가 지연됨을 알 수 있었다. pH의 변화에 있어서는 저장기간 동안 일정하게 유지되었으며, 실험구간의 pH는 유의적인 차이를 나타내지 않았다. 수분함량은 9일까지 유의적인 차이를 보이지 않았으나 15일과 21일에는 처리구가 무처리구보다 다소 높은 수분함량을 보였다. 색도의 경우에는 처리구의 명도와 황색도가 무처리구보다 다소 낮은 값을 나타냈다. 물성에서는 저장기간 전반에 걸쳐 처리구와 무처리구 간의 유의적인 차이를 보이지 않았다. 관능평가에서 맛은 처리구가 무처리구보다 낮은 기호도를 보였지만, 전체적인 기호도에서는 처리구와 무처리구가 유사한 기호도를 나타냈다. 이상의 결과를 종합해 볼 때 가시오가피와 두충 추출 혼합물을 1.5% 첨가할 경우 생면의 품질을 유지하면서 저장성 개선에 효과가 있을 것으로 사료된다.
High-frequency and high-quality silicon carbide optomechanical microresonators (2015)

Silicon carbide (SiC) exhibits excellent material properties attractive for broad applications. We demonstrate the first SiC optomechanical microresonators that integrate high mechanical frequency, high mechanical quality, and high optical quality into a single device. The radial-breathing mechanical mode has a mechanical frequency up to 1.69 GHz with a mechanical Q around 5500 in atmosphere, which corresponds to a fm · Qm product as high as 9.47 × 10(12) Hz. The strong optomechanical coupling allows us to efficiently excite and probe the coherent mechanical oscillation by optical waves. The demonstrated devices, in combination with the superior thermal property, chemical inertness, and defect characteristics of SiC, show great potential for applications in metrology, sensing, and quantum photonics, particularly in harsh environments that are challenging for other device platforms.
Effect of motivational behaviors and race/ ethnicity on academic success in physical therapy students: a preliminary study (2021)

Objectives: Doctor of Physical Therapy (DPT) program admissions criteria and markers indicative of academic success appear to be mismatched. Acceptance into a DPT program implies that students have developed self-regulated learning strategies however, motivation behaviors are not typically assessed during the admissions process. The aim of this study was to determine direct effects of motivational behaviors and race/ethnicity on academic success and the moderating effect of race/ethnicity on motivational behaviors. Methods: Thirty-three first-year DPT students participated during their first foundational course, clinical anatomy. Motivation subscales from the motivated strategies for learning questionnaire (MSLQ) were used to assess student motivation behaviors which were then compared to course grades. Results: Self-efficacy for learning and performance was significantly correlated with course grade [r(31)=0.44, p&lt; 0.05]. Course grade differed at a statistically significant level by race/ethnicity [t(31)=2.93, p&lt;0.01]. Race/ethnicity (B=0.05, SE=0.01, b=0.42, p&lt;0.008) and self-efficacy for learning and performance (B=0.02, SE=0.01, b=0.39, p&lt;0.01), remained significantly related to course grade. Conclusion: Self-efficacy for learning and performance and ethnicity are factors that determine academic success and could be utilized in DPT programs to aid in the development of teaching strategies to support students.
Vers la commande en boucle fermée d'un robot porte-optique : apport de l'analyse contextuelle d'images endoscopiques (2006)

The development of laparoscopy is closely linked to the advances in instrumentation, allowing to combine the efficacy of surgery and a minimally invasive approach. Today, robotic systems can assist a surgeon during a minimally invasive intervention, but their use is still controversial because of their bulkiness, their cost, and the change they might induce to surgical practice. Research trends in this field aim towards a better adaptation of these systems to surgical constraints.<br /><br />The objective of this Ph.D. Thesis was to control a robotized endoscopic camera holder thanks to " high-level " commands mimicking the task of the assistant in charge of manipulating the endoscope in conventional laparoscopy. First, I built a model of the field of laparoscopic surgery highlighting the role of the assistant. It allowed me to identify the commands primitives to develop. Then, I worked on the conception and development of the selected command primitives, especially a command dedicated to the robot's automatic tracking of surgical instruments based on the analysis of the endoscopic images. The instrument detection algorithm was first validated on numerized images extracted from surgical procedures. Then a cadaver experiment was performed, during which we were able to track a surgical instrument with the robot, in conditions close to clinical conditions.
BLACK PILOTS IN WORLD WAR I (2002)

BLACK PILOTS IN WORLD WAR I Get access ROGER LITTLE ROGER LITTLE Dublin Search for other works by this author on: Oxford Academic Google Scholar French Studies Bulletin, Volume 23, Issue 82, SPRING 2002, Pages 19–20, https://doi.org/10.1093/frebul/23.82.19 Published: 01 March 2002
Novel Haloperoxidase from the Agaric Basidiomycete Agrocybe aegerita Oxidizes Aryl Alcohols and Aldehydes (2004)

Agrocybe aegerita, a bark mulch- and wood-colonizing basidiomycete, was found to produce a peroxidase (AaP) that oxidizes aryl alcohols, such as veratryl and benzyl alcohols, into the corresponding aldehydes and then into benzoic acids. The enzyme also catalyzed the oxidation of typical peroxidase substrates, such as 2,6-dimethoxyphenol (DMP) or 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS). A. aegerita peroxidase production depended on the concentration of organic nitrogen in the medium, and highest enzyme levels were detected in the presence of soybean meal. Two fractions of the enzyme, AaP I and AaP II, which had identical molecular masses (46 kDa) and isoelectric points of 4.6 to 5.4 and 4.9 to 5.6, respectively (corresponding to six different isoforms), were identified after several steps of purification, including anion- and cation-exchange chromatography. The optimum pH for the oxidation of aryl alcohols was found to be around 7, and the enzyme required relatively high concentrations of H(2)O(2) (2 mM) for optimum activity. The apparent K(m) values for ABTS, DMP, benzyl alcohol, veratryl alcohol, and H(2)O(2) were 37, 298, 1,001, 2,367 and 1,313 microM, respectively. The N-terminal amino acid sequences of the main AaP II spots blotted after two-dimensional gel electrophoresis were almost identical and exhibited almost no homology to the sequences of other peroxidases from basidiomycetes, but they shared the first three amino acids, as well as two additional amino acids, with the heme chloroperoxidase (CPO) from the ascomycete Caldariomyces fumago. This finding is consistent with the fact that AaP halogenates monochlorodimedone, the specific substrate of CPO. The existence of haloperoxidases in basidiomycetous fungi may be of general significance for the natural formation of chlorinated organic compounds in forest soils.
Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2 (2022)

Galectin-3 binding protein (Gal-3BP) is a multifunctional glycoprotein involved in cell–cell and cell–matrix interactions known to be upregulated in cancer and various viral infections, including HIV-1, HCV, and SARS-CoV-2, with a key role in regulating the antiviral immune response. Studies have identified a direct correlation between circulating levels of Gal-3BP and the severity of disease and/or disease progression for some viral infections, including SARS-CoV-2, suggesting a role of Gal-3BP in these processes. Due to Gal-3BP’s complex biology, the molecular mechanisms underlying its role in viral diseases have been only partially clarified. Gal-3BP induces the expression of interferons (IFNs) and proinflammatory cytokines, including interleukin-6 (IL-6), mainly interacting with galectin-3, targeting the TNF receptor-associated factors (TRAF-6 and TRAF-3) complex, thus having a putative role in the modulation of TGF-β signaling. In addition, an antiviral activity of Gal-3BP has been ascribed to a direct interaction of the protein with virus components. In this review, we explored the role of Gal-3BP in viral infections and the relationship between Gal-3BP upregulation and disease severity and progression, mainly focusing on SARS-CoV-2. Augmented knowledge of Gal-3BP’s role in virus infections can be useful to evaluate its possible use as a prognostic biomarker and as a putative target to block or attenuate severe disease.
Aerodynamic flow vectoring of 2-D, co-flowing jets (1997)

A methodology for the aerodynamic thrust vectoring of a two-dimensional jet in a co-flowing stream is described. The sole control input to stimulate thrust vectoring is suction applied at the base region of blunt-faced lips forming the exit of the jet. Once the suction volume flux applied at the jet lips exceeds a critical value needed to suppress any global instability arising in the wake-shear layer formed behind either lip, local directional control of the streaming flow of the jet can be realized. Local directional control of the jet can be achieved by selectively varying the distribution of suction at the base of the jet lip on each side of the jet. The directional control of the flow is intimately linked to the symmetry properties of the nominal streaming flow and the applied suction distribution. (Author)