gebhart/patrepeval huggingface dataset:
698-P: Glycemic Improvement in 11,273 Adults with Type 1 Diabetes (T1D) Using the Omnipod Insulin Management System over First 90 Days of Use (2021)

Real-world evidence describing clinical outcomes in people with T1D using various devices is important to support decision-making. This retrospective study characterized patient-reported clinical outcomes in adults in the United States with T1D before (baseline) and 90 days after (follow-up) the initiation of a tubeless insulin pump (Omnipod® or Omnipod DASH® Insulin Management System). The primary outcome was change in self-reported HbA1c level from baseline to follow-up. Secondary outcomes were change in self-reported total daily dose (TDD) of insulin and self-reported frequency of hypoglycemic events (HE) per week (#/week <70 mg/dL). Outcomes were assessed overall and by prior treatment modality (MDI or CSII) and age group. Patients were aged 40.3±15.2y (mean±SD) and 59.1% female (Table). The overall change in self-reported HbA1c at follow-up was -0.8±1.5% (p<0.0001). Overall change in TDD of insulin was -10.5±20.6U/d (p<0.0001) and the self-reported HE frequency decreased significantly by -1.4±3.0 episodes per week (p<0.0001). Reductions in HbA1c, TDD and HE were seen regardless of prior treatment or age group. In this large cohort of adults with T1D, initiation of a tubeless insulin pump was associated with significant reductions in HbA1c, TDD of insulin, and number of HE after 90 days of use compared to prior MDI and CSII treatments and across age groups.View largeDownload slideView largeDownload slide DisclosureG. Aleppo: Consultant; Self; Dexcom, Inc., Insulet Corporation, Research Support; Self; Dexcom, Inc., Eli Lilly and Company, Insulet Corporation, Novo Nordisk. D. Desalvo: Consultant; Self; Insulet Corporation, Research Support; Self; Insulet Corporation, Speaker’s Bureau; Self; Dexcom, Inc. F. Lauand: Employee; Self; Insulet Corporation. L. M. Huyett: Employee; Self; Insulet Corporation, Stock/Shareholder; Self; Insulet Corporation. J. Jantz: Employee; Self; Insulet Corporation. A. Chang: Employee; Self; Insulet Corporation. T. Vienneau: Employee; Self; Insulet Corporation, Stock/Shareholder; Self; Insulet Corporation. T. T. Ly: Employee; Self; Insulet Corporation.FundingInsulet Corporation
<title>Zooming Web browser</title> (1996)

The World Wide Web (WWW) is becoming increasingly important for business, education, and entertainment. Popular web browsers make access to Internet information resources relatively easy for novice users. Simply by clicking on a link, a new page of information replaces the current one on the screen. Unfortunately however, after following a number of links, people can have difficulty remembering where they've been and navigating links they have followed. As one's collection of web pages grows and as more information of interest populates the web, effective navigation becomes an issue of fundamental importance. We are developing a prototype zooming browser to explore alternative mechanisms for navigating the WWW. Instead of having a single page visible at a time, multiple pages and the links between them are depicted on a large zoomable information surface. Pages are scaled so that the page in focus is clearly readable with connected pages shown at smaller scales to provide context. As a link is followed the new page becomes the focus and existing pages are dynamically repositioned and scaled. Layout changes are animated so that the focus page moves smoothly to the center of the display surface while contextual information provided by linked pages scales down. While our browser supports multiscale representations of existing HTML pages, we have also extended HTML to support multiscale layout within a page. This extension, Multi-Scale Markup Language, is at an early stage of development. It currently supports inclusion within a page of variable-sized dynamic objects, graphics, and other interface mechanisms from our underlying Pad++ substrate. This provides sophisticated client- side interactions, permits annotations to be added to pages, and allows page constituents to be used as independent graphical objects. In this paper, we describe our prototype web browser and authoring facilities. We show how simple extensions to HTML can support sophisticated client-side interactions. Finally, we discuss the results of preliminary user-interface testing and evaluation.
Tecnología blockchain y regulación de la trazabilidad: la digitalización de la calidad y seguridad alimentarias (2019)

La repercusion economica, politica, juridica y social del sistema de seguridad 
alimentaria y calidad de los alimentos es innegable. La trazabilidad, como un elemento 
trascendental del sistema de seguridad alimentaria garantiza el control que permite la seguridad 
siendo reivindicada como cierre del sistema “desde la granja a la mesa”. La utilizacion de la 
tecnologia blockchain como herramienta facilitadora de la trazabilidad en la alimentacion es el 
tema de este estudio que no pretende mas que describir la regulacion de la seguridad alimentaria 
en la actualidad y los retos de la aplicacion del blockchain al sistema.
A 12-b digital-background-calibrated algorithmic ADC with -90-dB THD (1999)

An analog queue-based architecture and an adaptive digital-calibration algorithm calibrate a 12-b algorithmic analog-to-digital converter in the background. At a sampling rate of 125 ksample/s and with monolithic background calibration, the peak signal-to-(noise+distortion) ratio is 71 dB, and the spurious-free dynamic range is 95 dB. The total power dissipation is 16 mW from 5 V. The active area is 5.9 mm/sup 2/ in 1.5-/spl mu/m CMOS.
Teaching Hospital Status and Operative Mortality in the United States (2010)

With the inclusion of benign disease, colon surgery displays a volume-outcome relationship in favor of non-THs. Inclusion of benign disease may represent a tipping point.
Iron‐catalyzed hydrosilylation of diacids in the presence of amines: a new route to cyclic amines (2020)

Abstract Cyclic amines (such as pyrrolidines, piperidines and azepanes) are present in a large class of natural products and bioactive molecules. Herein, we present a novel chemoselective strategy for building N ‐substituted cyclic amines via iron catalyzed one‐pot hydrosilylation starting from readily available dicarboxylic acids and amines, with hydrosilanes as the hydride sources. The described methodology allows the preparation of a wide range of N ‐alkylated and arylated cyclic amine derivatives (including pharmaceuticals Fenpiprane and Prozapine) in moderate to excellent yields, starting from inexpensive succinic, glutaric, and adipic acids with dimethyl carbonate as a green solvent.
Physical factors governing the shape of the Miram curve knee in thermionic emission (2022)

In a current density versus temperature (J-T) (Miram) curve in thermionic electron emission, experimental measurements demonstrate there is a smooth transition between the exponential region and the saturated emission regions, which is sometimes referred to as the "roll-off" or "Miram curve knee". The shape of the Miram curve knee is an important figure of merit for thermionic vacuum cathodes. Specifically, cathodes with a sharp Miram curve knee at low temperature with a flat saturated emission current are typically preferred. Our previous work on modeling nonuniform thermionic emission revealed that the space charge effect and patch field effect are key pieces of physics which impact the shape of the Miram curve knee. This work provides a more complete understanding of the physical factors connecting these physical effects and their relative impact on the shape of the knee, including the smoothness, the temperature, and the flatness of the saturated emission current density. For our analyses, we use a periodic, equal-width striped ("zebra crossing") work function distribution as a model system and illustrate how the space charge and patch field effects restrict the emission current density near the Miram curve knee. The results indicate there are three main physical parameters which significantly impact the shape of the Miram curve. Such physical knowledge directly connects the patch size, work function values, anode-cathode voltage, and anode-cathode gap distance to the shape of the Miram curve, providing new understanding and a guide to the design of thermionic cathodes used as electron sources in vacuum electronic devices (VEDs).
A truncated cytoplasmic topoisomerase IIα in a drug-resistant lung cancer cell line is encoded by aTOP2A allele with a partial deletion of exon 34 (2000)

To study the problem of acquired resistance to widely used anti-cancer drugs that target the 170 kDa topoisomerase IIalpha (topo IIalpha), a drug-resistant human small-cell lung cancer cell line, H209/VP, was selected in VP-16. H209/VP cells express reduced levels of the 170 kDa topo IIalpha that is localized normally in the nucleus and also express lower levels of a 160 kDa topo IIalpha-related protein that is located predominantly in the cytoplasm. Band depletion immunoblotting experiments suggest that the H209/VP nuclear 170 kDa topo IIalpha is able to form ternary complexes with DNA and VP-16 in intact cells, but the ability of the cytoplasmic 160 kDa protein to do so is greatly diminished. Sequence analysis of the 3; end of the H209/VP mutant topo IIalpha mRNA and the TOP2A gene indicates that the mRNA is missing 200 nt that corresponds to exon 34 because the partial loss of the minimal 3; splice-acceptor sequence at the beginning of exon 34 results in splicing of exon 33 to exon 35. The protein predicted to be encoded by this mutant mRNA does not contain the COOH-terminal 109 amino acids of the wild-type enzyme that we have demonstrated contain a strongly functional nuclear localization signal sequence. Consequently, our data explain both the size and the cytoplasmic localization of the H209/VP mutant topo IIalpha. The mutant TOP2A allele in H209/VP cells differs from those in previously characterized cell lines with cytoplasmic topo IIalpha and extends the number of types of resistance-associated deletions in this region to 4. These findings indicate that this region of the TOP2A gene may be a hot spot for mutations.
Distribution of Toxoplasma Antibodies in Slaughtered Hogs and Workers of a Tokyo Abattoir (1963)

1. A total of 317 serum samples were collected from apparently healthy hogs slaughtered at the Shibaura Slaughterhouse in Tokyo. Of them, 17 per cent gave positive complement fixation tests with a titer of at least 1: 8 after treatment with KIO4. About 80 per cent of these positive serum samples also gave positive dye teste with a titer of at least 1: 16.2. Positive toxoplasmin intradermal tests were given by 7.7 per cent of 261 hogs slaughtered. Toxoplasma organisms were isolated in mice from 2 of 2 positive hogs and 2 of 43 negative hogs examined.3. Epidemiological surveys were conducted on the workers of the same slaughterhouse in 1960 and 1961, by using the toxoplasmin intradermal test and dye test. As a result, positive toxoplasmin and dye tests were given by 67.8 and 59.1 per cent, respectively, in 1960 and 57.4 and 61.8 per cent in 1961.These surveys indicate that toxoplasmosis has been spread among swine in Japan to a considerably large extent and that swine play an important part in the transmission of this disease to man.
WiMAX Simulation module with management architecture and signaling exchanges (2009)

The Worldwide Interoperability forMicrowave Access (WiMAX) has drawn tremendous interest from researchers as it is a very promising wireless access technology. Newly developed protocols need to be tested, evaluated and readjusted before becoming operative. In this paper, we present new WiMAX model f
Developments in non-radioactive microsphere techniques for blood flow measurement (1994)

Considerable progress is being made in the development of non-radioactive microsphere methods. Validation studies of the three commercially available non-radioactive microspheres are promising. In most experimental conditions the use of non-radioactive microspheres saves money. Avoiding the use of radioactivity facilitates the use of microspheres in chronic animal experiments and when blood flow and chemical measurements are performed in the same sample. Moreover, using histological techniques, distributions of coloured or fluorescent microspheres in subunits of organs could be quantified, opening new scientific possibilities. Currently, the fluorescent microsphere technique seems to be the most promising non-radioactive microsphere method. Due to the high sensitivity and good spectral separation, the number of microspheres injected can be as small as that used, for radioactive microspheres, at least six labels can be used, and the relatively large volume in which fluorescence is measured (approximately 1-3 ml) enables the use of time saving microsphere isolation techniques. Development of these methods and further automation of the quantification process (using either automised spectrometry or FACS analysis) will considerably increase interest in the non-radioactive microsphere techniques. To accelerate these developments, investigators are encouraged to share their experiences.
Unusual Sjögren's Syndrome with Bilateral Parotid Cysts (2014)

Sjögren's syndrome is a chronic autoimmune exocrinopathy that destroys salivary and lacrimal gland tissue. We report an unusual case of this disease in a 54-year-old woman who presented with multiple and bilateral parotid cystic masses. The multiple, small, bead-like cysts were clearly evident in the computed tomography sections in this patient, a visible reminder that this may be the initial presentation in a patient with Sjögren's syndrome. As the case illustrates, Sjögren's syndrome should be included in the differential diagnosis of multiple and bilateral cystic parotid lesions.
OPC for double exposure lithography (2005)

In DRAM technology, rapidly decreasing critical dimensions cause a strong need in lithography for optimization of illumination conditions. In critical line levels, this will lead to an increasing demand for application of different, specially optimized illuminations to differently structured layout portions. Such a strategy can be achieved by double exposure techniques. A major technical challenge in this approach is the case in which electrically connected layout regions are assigned to different litho illuminations. Here, the layout separation onto different masks must preserve a sufficient process window in the electrically connected layout cut regions. A key success factor is a double exposure aware OPC strategy, able to describe and correct layouts defined by the interaction of two exposures with different illumination settings. In our contribution, we present the results of a double exposure experiment for a critical metal level. A likewise mask-manufacturing-friendly and litho-friendly method of layout separation on 'double tri-tone masks' was developed. Mask and wafer results show the principal feasibility of the chosen concept and prove the necessary OPC functionality.
A new hybrid FDTD field-teleportation approach for modeling radiating/scattering structures (2005)

The essence of the technique, called Field Teleportation, is to invoke the principle of equivalent sources (Schelkunoff's currents) using FDTD's discrete definition of the curl to copy any field propagating in one FDTD domain to a finite region of another domain without distortion [1]. Here an approach to teleport a frequency domain field into FDTD domain has been successfully tested for realistic large objeet scattering problem. The teleported field is used in FDTD to illuminate a scattering object introduced into the test region and the time-domain scattered signal has been transformed back into the frequency domain as induced equivalent surface currents. Having these currents, calculation of the farfield scattering becomes a trivial procedure. For the case of an exact frequency-domain solution, the error introduced by field-teleportation for 5λ 5λ by 2λ modeled space with PEC boundary is less than -110 dB and the phase error is less than 0.16 degree. For the case of field obtained by Uuiform Theory of Diffraction (UTD) on condense grid, intrinsic error has not exceeded -60 dB in magnitnde and ±3 degree in phase. In this case main e m r caused by H-field retrieving from E-field on condensed (non-Yee) grid. Our modeling shows high importance of the grid matching between any frequency domain method and FDTD (E and H-field components have to he found on Yee-grid for the hest field teleportation).
FRET detection using Total Internal Reflection Fluorescence Lifetime Imaging Microscopy and supercontinuum excitation (2008)

International audience
Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas (2014)

High expression of MCM 2, MCM3 and MCM7 mRNA correlated with poor outcome and may be clinically useful molecular prognostic markers in glioma.
Scale-invariant line descriptors for wide baseline matching (2014)

In this paper we propose a method to add scale-invariance to line descriptors for wide baseline matching purposes. While finding point correspondences among different views is a well-studied problem, there still remain difficult cases where it performs poorly, such as textureless scenes, ambiguities and extreme transformations. For these cases using line segment correspondences is a valuable addition for finding sufficient matches. Our general method for adding scale-invariance to line segment descriptors consist of 5 basic rules. We apply these rules to enhance both the line descriptor described by Bay et al. [1] and the mean-standard deviation line descriptor (MSLD) proposed by Wang et al. [14]. Moreover, we examine the effect of the line descriptors when combined with the topological filtering method proposed by Bay et al. and the recent proposed graph matching strategy from K-VLD [6]. We validate the method using standard point correspondence benchmarks and more challenging new ones. Adding scale-invariance increases the accuracy when confronted with big scale changes and increases the number of inliers in the general case, both resulting in smaller calibration errors by means of RANSAC-like techniques and epipolar estimations.
Directional deconvolution of marine seismic data in the frequency-wavenumber domain (1993)

Marine seismic sources arrays are directional because they are not monopoles. That is, they are not small compared with the wavelengths of acoustic radiation they produce. This directional effect is important for a number of processes in which the source must be known and in which it is assumed to be a monopole. These include signature deconvolution, the removal of water layer multiples, amplitude-versus-offset (AVO) analysis, and pre-stack inversion.
Dataset of middle cerebral artery blood flow stability in response to high-definition transcranial electrical stimulation (2022)

This supplementary dataset is supportive of the randomized sham-controlled, double-blind, crossover clinical trial investigating polarity- and intensity-dependent effects of high-definition transcranial electrical stimulation (HD-tDCS) applied over the right temporo-parietal junction on mean middle cerebral artery blood flow velocity (MCA-BFv) bilaterally. Data of eleven healthy right-handed adults (6 women, 5 men; mean age 31 ± 5.6 years old) were analyzed for MCA-BFv, assessed using transcranial doppler ultrasound on the stimulated and the contralateral hemisphere concomitantly, during and after 3 blocks of 2 min HD-tDCS at 1, 2, and 3 mA. Participants received three electrical stimulation conditions (anode center, cathode center, and sham) randomly ordered across different days. The collected data is publicly available at Mendeley Data. This article and the data will inform future related investigations and safety analysis of transcranial non-invasive brain stimulation.
Potentially Pathogenic Organisms in Stools and Their Association With Acute Diarrheal Illness in Children Aged &lt;2 Years (2021)

Wild-type rotavirus, norovirus GII, sapovirus GI/II/IV/V, adenovirus 40/41, and Salmonella were associated with ADI in this age group and setting. However, high levels of asymptomatic shedding of potential pathogens in stools from children may contribute to diagnostic confusion when children present with an episode of ADI.
Multiple-Mode Dynamic Model for Piezoelectric Micro-Robot Walking (2016)

A multiple-mode dynamic model is developed for a piezoelectrically-actuated micro-robot with multiple legs. The motion of the micro robot results from dual direction motion of piezoelectric actuators in the legs, while the complexity of micro robot locomotion is increased by impact dynamics. The dynamic model is developed to describe and predict the micro robot motion, in the presence of asymmetrical behavior due to non-ideal fabrication and variable properties of the underlying terrain. The dynamic model considers each robot leg as a continuous structure moving in two directions derived from beam theory with specific boundary condition. Robot body motion is modeled in six degrees of freedom using a rigid body approximation. Individual modes of the resulting multimode robot are treated as second order linear systems. The dynamic model is tested with a meso-scale robot prototype having a similar actuation scheme as micro-robots. In accounting for the interaction between robot and ground, the dynamic model with first two modes of each leg shows good match with experimental results for the mesoscale prototype, in terms of both magnitude and the trends of robot locomotion with respect to actuation conditions.
Bioinformatics applications of information extraction from scientific journal articles (2000)

Information extraction technology, as defined and developed through the US Defense Advanced Research Projects Agency (DARPA) Message Understanding Conferences (MUCs), has proved successful at extracting information primarily from newswire texts and primarily in domains concerned with human activity. In this paper, the application of this technology to the extraction of information from scientific journal papers in the area of molecular biology is considered. In particular, it is described how an information extraction designed to participate in the MUC exercises has been modified for two bioinformatics applications: one concerned with enzyme and metabolic pathways; the other with protein structure. Progress to date provides convincing grounds for believing that information extraction techniques will deliver novel and effective ways for scientists to make use of the core literature which defines their disciplines.
Conceptual Design As Novel Combination of Existing Device Features (1987)

Abstract Conceptual design is the initial stage of the transformation between functional and structural descriptions of devices. Our primary aim is to develop ideas that will allow computer tools for conceptual design to be built. In this paper, we point out a fundamental trade-off between the expressiveness of design languages and the computational complexity of the resulting design problem. Research in computational conceptual design can therefore be viewed as the problem of defining a design language and then devising ways of controlling the size of the resulting design space. We propose that an effective means of controlling complexity is to use knowledge of existing designs to guide the synthesis of novel designs. We illustrate this concept with a program that designs novel mechanical fasteners from knowledge of existing fasteners. We analyze this experiment and highlight several areas for future work.
Accuracy of the Flow Velocity and Three-directional Velocity Profile Measured with Three-dimensional Cine Phase-contrast MR Imaging: Verification on Scanners from Different Manufacturers (2019)

In this study, we have demonstrated that the accuracy of flow velocity and three-directional velocity components in 3D cine PC MRI was satisfactory in all three MR scanners.