gebhart/patrepeval huggingface dataset:
Model Predictive Control of HVAC Systems: Design and Implementation on a Real Case Study (2013)

The final aim of this work is to design, implement and test a controller on a real testbed kindly provided by KTH. The control paradigm presented in this thesis is a MPC that aims at saving energy as well as keeping the temperature and the CO2 concentration in a comfort range that guarantees the wellness of room occupants. To improve the knowledge of the plant, we also study the problem of modeling both the dynamics of of the system to be controlled and of the dedicated actuation system
ChemInform Abstract: Gold‐Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines. (2014)

Abstract A novel method for the synthesis of indoloquinoline compounds via the gold‐catalyzed cascade cyclization of (azido)ynamides is described.
Ventricular Fibrillation Induced by Spontaneous Hypothermia in a Patient with Early Repolarization Syndrome (2012)

Hypothermia is an important trigger of VF in the setting of early repolarization syndrome, and warrants assessment as an environmental trigger of spontaneous events.
Modellbildung für das dreiachsige Gesamtsystem (1989)

Nach Abhandlung der Antriebsnichtlinearitäten in Abschnitt 3.2 wird zur Synthese einer Regelung für das Gesamtsystem ein mathematisches Modell des kompletten Versuchsstandes aus Abschnitt 2.1 benötigt. Um ein Modell für alle Betriebspunkte zu erhalten und später leicht Veränderungen und Erweiterungen vornehmen zu können, erfolgt eine symbolische Modellbeschreibung mit physikalischen Parametern.
Probing the Photoionization Dynamics of 2-Cyclopenten-1-one via High-Resolution VUV-MATI Spectroscopy (2021)

2-Cyclopenten-1-one (2CP), which is a cyclic enone, has been considered an important precursor because of its versatile functionality in the synthesis of natural products and materials for biofuels. Here, we report the adiabatic ionization energy (AIE) and cationic structure of 2CP in the ionic transition between the neutral S<sub>0</sub> and the cationic D<sub>0</sub> states probed by high-resolution vacuum ultraviolet mass-analyzed threshold ionization (VUV-MATI) spectroscopy. From the 0-0 band position in the VUV-MATI spectrum supported by the VUV-photoionization efficiency curve, the AIE of 2CP was determined to be 9.3477 ± 0.0004 eV (75,395 ± 3 cm<sup>-1</sup>), which is in good agreement with the reference value but much more accurate. The measured MATI spectrum combined with the Franck-Condon fitting at the B3LYP/cc-pVTZ level revealed that the cationic structure of 2CP is twisted with the C<sub>1</sub> symmetry, whereas the neutral 2CP has the C<sub>S</sub> symmetry. The results indicate that geometrical changes induced by ionization are mainly attributed to the electron removal from the highest occupied molecular orbital, which consists of nonbonding orbitals on the oxygen atom in the carbonyl group interacting with the σ orbitals in the molecular plane of 2CP. Consequently, lowering the C<sub>1</sub> symmetry for cationic 2CP led to the promotions of the ring-bending and ring-twisting modes in the MATI spectrum, which correspond to the ring puckering and C═C twisting in the S<sub>0</sub> state, respectively.
Dendron‐Functionalized Polyglutamate‐Pyropheophorbide‐a Conjugates as Nanomedicines for Breast Cancer Photodynamic Therapy (2021)

Photodynamic therapy (PDT) has shown its promise in the treatment of cancer. Herein, a dendron-functionalized polyglutamic acid (PGA) polymer (PG-L8G-Ppa-Dendron, PGPD) is synthesized and it is conjugated with pyropheophorbide-a (Ppa) for the first time to treat triple negative breast cancer (TNBC), whereas a linear polyglutamate-Ppa conjugate (PGP) is synthesized as a control. Compared to the linear counterpart, the glycosylated polymer-based PGPD with a dendritic structure has excellent solubility and it self-assembles to form uniform-sized nanoparticles. PGPD displays a highly effective PDT effect in the animal model, evidenced with effective induction of reactive oxygen species (ROS) production and cell apoptosis. This may be due to an enhanced efficiency in delivery and accumulation of Ppa by this glycosylated dendritic polymer at tumor sites. Therefore, PGPD can be a highly effective and biosafe nanoagent for PDT of TNBC.
A Scoping Review of Research on the Human Milk Microbiome (2020)

We have suggested concerns about collection and measurement that lead to gaps in knowledge generation, and mechanistic studies are lacking.
Decision-based interactive model to determine re-opening conditions of a large university campus in Belgium during the first COVID-19 wave (2022)

In a real life setting in a University campus, periodic screening could contribute to limiting the SARS-CoV-2 pandemic cycle but is highly dependent on its environment.
Advances in the modeling of laser direct metal deposition (2014)

This paper provides a review of the current state of the art in modeling of laser direct metal deposition and cladding processes and identifies recent advances and trends in this field. The different stages of the process and the features, strengths and weaknesses of models relating to them are discussed. Although direct metal deposition is now firmly in the industrial domain, the benefits to be gained from reliable predictive modeling of the process are still to be fully exploited. The genuine progress there has been in this field in the last five years, particularly in discretized modeling, means modeling cannot be overlooked as an enabling method for academia and industry, but there is still more work to be done.
Robustness of the EWMA median control chart to non-normality (2016)

The control charts with exponentially weighted moving average (EWMA) had been shown to be effective for detecting small shifts in the mean of the process characteristic. When the data depart from normality or have the presence of outliers, the sample median might be used to provide a fairer representation of centrality of the data. In the present paper, the performances of the EWMA median control charts are evaluated under several distributions. The average run length (ARL) is applied to evaluate the performance of control charts, and the method for calculating ARL of the EWMA median chart is developed using the integral equation approach. Based on our study, the EWMA median chart with a small value of smoothing constant has a low false alarm rate. But as the shift of process mean is large, to maintain the detection ability of the chart, the value of smoothing constant should be increased. In addition, if the data follow a heavy-tailed distribution, it can be shown that the EWMA median chart is always more efficient than the EWMA average chart in detecting the shift of process mean.
Tunneling gate oxide approach to ultra-high current drive in small geometry MOSFETs (2002)

Ultra-high performance n-MOSFETs were fabricated with a tunneling gate oxide 1.5 nm thick. It was found that these devices operate well when the gate length is around 0.1 /spl mu/m, because gate leakage current falls in proportion to the gate length and the drain current increases in inverse proportion. A very high drivability of 1.1 mAspl mu/m at 15 V was obtained, even in devices with a 0.14 pm gate length. A record high transconductance, 1,010 mS/mm at room temperature was also obtained in 0.09 /spl mu/m MOSFETs. Confirmation was obtained that hot-carrier reliability improves as the gate oxide thickness is reduced, even in the 1.5 nm case. High current drive at the low supply voltage of 0.5 V was also demonstrated. We made clear that very high performance is obtained in Si MOSFETs, if we can use a high capacitance gate insulator. In future devices, the tunnel gate oxide may be a good candidate for such a gate film, depending upon their applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
4. Radiopharmaceutical aspects of 111In-Octreoscan therapy (1997)

1Department of Nuclear Medicine, King's College Hospital, London, UK 2Department of Nuclear Medicine, University Hospital Rotterdam, The Netherlands
Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes (2000)

In human astrocytes, interleukin-1β (IL-1β) is a potent inducer of genes associated with inflammation. In this study, we tested the hypothesis that in primary cultures of human fetal astrocytes signaling by the P2 purinergic nucleotide receptor pathway contributes to, or modulates, cytokine-mediated signal transduction. Calcium imaging studies indicated that most cells in culture responded to ATP, whereas only a subpopulation responded to UTP. Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1β-stimulated expression of nitric oxide, tumor necrosis factor (TNFα), and IL-6 at both the protein and mRNA levels, without affecting cell viability. In cells transiently transfected with reporter constructs, IL-1β demonstrated more potent activation of the transcription factors nuclear factor -κB (NF-κB) and activator protein-1 (AP-1) than TNFα. However, pretreatment with oATP downregulated activation of NF-κB and AP-1 by IL-1β or TNFα. Electromobility shift assays using oligonucleotides containing specific NF-κB binding sequences confirmed that pretreatment with oATP or apyrase attenuated cytokine-mediated induction of this transcription factor. From these data, we conclude that P2 receptor-mediated signaling intersects with that of IL-1β and TNFα to regulate responses to cytokines in the CNS. Because inflammation, trauma, and stress all lead to the release of high levels of extracellular nucleotides, such as ATP and UTP, signaling via P2 receptors may provide a mechanism whereby cells can sense and respond to events occurring in the extracellular environment and can fine tune the transcription of genes involved in the inflammatory response.
Standard Reference Materials : (2001)

was established in 1988 by Congress to "assist industry in -Jl the development of technology . . . needed to improve product quality, to modernize manufacturing processes, to ensure product reliability . . . and to facilitate rapid commercialization ... of
Rb87hyperfine-transition dephasing in mixed buffer-gas systems (2007)

Elucidating the mechanisms of dephasing in the alkali-metal ground state hyperfine transition has remained an unsatisfactorily resolved problem since the mid-1960s, even though its solution has relevance to next-generation atomic clocks. Recently, however, measurements of electronic spin relaxation in strong magnetic fields have resolved a number of outstanding ambiguities, and the situation has greatly improved. Unfortunately, while these studies have illuminated the processes contributing to hyperfine transition dephasing, they only allow one to infer actual dephasing rates, $\ensuremath{\gamma}$. The direct measurement of dephasing rates remains problematic, primarily as a result of temperature gradient inhomogeneous broadening, which makes it nearly impossible to distinguish systematic from physical effects. Here, we demonstrate that by measuring $\ensuremath{\gamma}$ as a function of mole fraction in mixed buffer-gas systems we can isolate temperature gradient effects, thereby allowing a direct comparison between theory and experiment. In the present work, we examine the linewidth of the $^{87}\mathrm{Rb}$ hyperfine transition in $\mathrm{Ar}\text{\ensuremath{-}}{\mathrm{N}}_{2}$ mixed buffer-gas systems. We obtain good agreement between theory and experiment so long as we include the full dephasing contribution from RbAr van der Waals molecules: the spin-rotation contribution, ${\ensuremath{\gamma}}_{\mathrm{SR}}$, and the contribution from the change in $^{87}\mathrm{Rb}$ hyperfine coupling, ${\ensuremath{\Gamma}}_{B}$, which we refer to as the Bouchiat rate. We have been able to measure ${\ensuremath{\Gamma}}_{B}$, obtaining ${\ensuremath{\Gamma}}_{B}=87\ifmmode\pm\else\textpm\fi{}6\phantom{\rule{0.3em}{0ex}}{\mathrm{s}}^{\ensuremath{-}1}$ for RbAr.
P2‐060: Comparison of Alzheimer and vascular dementia patients using MRI‐based measures of atrophy (2008)

Research criteria exist for the identification of dementia of the Alzheimer's type (AD, NINCDS-ADRDA) and vascular dementia (VaD, NINDS-AIREN). However, both research and regulatory communities are uncertain of the criteria's ability to identify non-overlapping study populations as the two diseases are co-incident among the age cohorts typically selected for study. We examined the ability of MRI criteria to distinguish well-characterized research samples of these two dementias, one an RCT in VaD and the second a long-running study of AD probands and unaffected family members (MIRAGE). The MRI variables examined were determined by blind ratings of MRI by a single rater (CD) common to both research studies. Both overall cerebral and hippocampal atrophy were compared for 277 MIRAGE AD cases and 826 VaD cases. While these groups share extensive overlap in severity of atrophy, several trends were identified. Logistic regression analysis with case status (VaD-yes, AD-no) as the outcome, controlling for age, gender, and level of cognitive functioning (MMSE), indicated a greater level of cerebral atrophy among VaD cases (p=1.28e-8) and greater hippocampal atrophy among AD cases (p=1.72e-9). Furthermore, asymmetric hemispheric atrophy characterized the VaD cases, whether or not the asymmetry was relegated to the hippocampus (p=.0243) or was found in the cerebrum (p=0.000451). The difference in likelihood of asymmetric atrophy was noteable: 3% of the AD sample and 18% of the VAD sample exhibited asymmetry according to the cerebral atrophy measure. We used the C statistic (area under the ROC curve) to determine discrimination of AD from VaD. The C statistic for a baseline model of demographic variables was 0.72, while adding the atrophy measures to the model increased the C statistic to 0.80. In fact, a model including only the atrophy measures yields C= 0.76. Both the overlap in levels of atrophy and the highly selected nature of these samples require that caution be used when interpreting these results. The low specificity of the asymmetry results for identifying VaD versus AD cases limits its usefulness as a general diagnostic index. However, these data could help discriminate VaD from AD cases when asymmetry is clearly present.
Molecular Analysis of Rifampin Resistance in Bacillus anthracis and Bacillus cereus (2002)

Rifampin-resistant mutants were selected from UV-light-treated Bacillus cereus (20 mutants) and attenuated B. anthracis (23 mutants). In addition, spontaneous rifampin-resistant mutants were also isolated in attenuated B. anthracis (22 mutants). The rifampin resistance clusters of the rpoB gene were sequenced for all 65 mutants. Mutations associated with resistance were consistent with those from other bacteria, though two novel changes were observed. The spontaneous rate of resistance was estimated at 1.57 x 10(-9) mutations/generation by a Luria-Delbrück fluctuation test.
Nucleophilic displacements in substituted pyridine N-oxides. Part I. Kinetics of the reactions between sodium ethoxide and 2- and 4-bromo-, 4-chloro-, 2-, 3-, and 4-nitro-, 4-chloro-3,5-dimethyl-, and 3,5-dimethyl-4-nitro-pyridine 1-oxide in anhydrous ethanol (1966)

Rates of reaction of halogeno- and nitro-pyridine N-oxides with sodium ethoxide in anhydrous ethanol have been measured and the Arrhenius parameters calculated and discussed.The reaction rates, entropies, and energies of activation for nitro-group displacements all decrease in the order 2 > 4 > 3. With the bromopyridine N-oxides both the entropy and energy of activation decrease in the order 4 > 2, but the positional reactivity is 2 > 4. Two methyl groups adjacent to the leaving group retard the reactions of 4-bromo- and 4-nitro-3,5-dimethylpyridine 1-oxides. Low activation energies are attributed to hindrance of nitro-group conjugation in the ground state, either by N-oxide oxygen dipolar repulsion (for 2-nitropyridine 1-oxide) or steric inhibition (in 3,5-dimethyl-4-nitropyridine 1-oxide).Small negative (or small positive) values obtained for activation entropies are attributed to extensive desolvation in forming the transition state. The very high entropy of activation for the reaction of 2-nitropyridine 1-oxide is attributed to the increased freedom of rotation of the nitro-group in the transition state compared to the restriction imposed by the N-oxide oxygen in the ground state.
Tamper resistant software (2001)

In this paper we illustrate how Tamper Resistant Software or TRS, can within a temporal window extend trust into a hostile environment such as mobile devices and set top boxes. We state and reference our approach to TRS and illustrate a high level attack. We currently estimate that it would take a Class II attacker a month to reverse engineer the TRS we can automatically produce from an existing program. This is based on Data Flow encoding only. With Control Flow encoding and improved Data Flow encodings we expect the attack times to exceed a year.
الكشف عن الذرات المفردة باستعمال أشعة الليزر (1986)

eY cieeyte keta. 4.):5_11
Intracellular calcium transients evoked by pulsed infrared radiation in neonatal cardiomyocytes (2011)

Neonatal rat ventricular cardiomyocytes were used to investigate mechanisms underlying transient changes in intracellular free Ca2+ concentration ([Ca2+]i) evoked by pulsed infrared radiation (IR, 1862 nm). Fluorescence confocal microscopy revealed IR-evoked [Ca2+]i events with each IR pulse (3-4 ms pulse⁻¹, 9.1-11.6 J cm⁻² pulse⁻¹). IR-evoked [Ca2+]i events were distinct from the relatively large spontaneous [Ca2+]i transients, with IR-evoked events exhibiting smaller amplitudes (0.88 ΔF/F0 vs. 1.99 ΔF/F0) and shorter time constants (τ =0.64 s vs. 1.19 s, respectively). Both IR-evoked [Ca2+]i events and spontaneous [Ca2+]i transients could be entrained by the IR pulse (0.2-1 pulse s⁻¹), provided the IR dose was sufficient and the radiation was applied directly to the cell. Examination of IR-evoked events during peak spontaneous [Ca2+]i periods revealed a rapid drop in [Ca2+]i, often restoring the baseline [Ca2+]i concentration, followed by a transient increase in [Ca2+]i.Cardiomyocytes were challenged with pharmacological agents to examine potential contributors to the IR-evoked [Ca2+]i events. Three compounds proved to be the most potent, reversible inhibitors: (1) CGP-37157 (20 μM, n =12), an inhibitor of the mitochondrial Na+/Ca2+ exchanger (mNCX), (2) Ruthenium Red (40 μM, n =13), an inhibitor of the mitochondrial Ca2+ uniporter (mCU), and (3) 2-aminoethoxydiphenylborane (10 μM, n =6), an IP3 channel antagonist. Ryanodine blocked the spontaneous [Ca2+]i transients but did not alter the IR-evoked events in the same cells. This pharmacological array implicates mitochondria as the major intracellular store of Ca2+ involved in IR-evoked responses reported here. Results support the hypothesis that 1862 nm pulsed IR modulates mitochondrial Ca2+ transport primarily through actions on mCU and mNCX.
Antioxidant Activity of Maltol, Kojic Acid, Levulinic Acid, Furfural, 5-Hydroxymethyl Furfural, and Pyrazine (1982)

An attempt was made to investigate the antioxidant activity of maltol, kojic acid, levulinic acid, furfural, 5-hydroxymethyl furfural (5-HMF), and pyrazine which had been known to be important intermediates of Maillard browning reactions. The activity of these compounds was determined by comparing induction periods of soybean oil substrates containing each compound at a 0.01M level with that of a control. The induction period was arbitrarily taken as the time in hours for a substrate to reach a peroxide value of 60meq/kg oil. The substrates and control were stored at for 30 days. The induction periods of the control, kojic acid, furfural, 5-HMF, maltol, levulinic acid, and pyrazine were respectively 468, 592, 510, 498, 486, 450, and 402 hours. Kojic acid demonstrated considerable antioxidant activity, whereas furfural, 5-HMF, and maltol showed weak activivity. Pyrazine and levulinic acid showed pro-oxidant activity. Although the prooxidant activity of pyrazine seemed definite, that of levulinic acid appeared very weak.
Reservoir characterization using geostatistical inversion for the Amberjack Field, offshore Gulf of Mexico (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Reservoir characterization using geostatistical inversion for the Amberjack Field, offshore Gulf of MexicoAuthors: Rebecca LatimerSteve BahretClaire SullivanRobert HorineWilliam MillsVanessa SturrockRebecca LatimerJason Geosystems, Steve BahretJason Geosystems, Claire SullivanBP‐Amoco, Robert HorineBP‐Amoco, William MillsBP‐Amoco, and Vanessa SturrockBP‐Amocohttps://doi.org/10.1190/1.1815692 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1815692FiguresReferencesRelatedDetailsCited ByFrom qualitative to quantitative interpretation: An interpreter's guide to fluid prediction in Pliocene to Turonian deepwater turbidites from West Africa to Asia PacificUwe Strecker, Paola Vera de Newton, and Maggie Smith11 February 2014 | Interpretation, Vol. 2, No. 1 SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Rebecca Latimer, Steve Bahret, Claire Sullivan, Robert Horine, William Mills, and Vanessa Sturrock, (2000), "Reservoir characterization using geostatistical inversion for the Amberjack Field, offshore Gulf of Mexico," SEG Technical Program Expanded Abstracts : 1506-1508. https://doi.org/10.1190/1.1815692 Plain-Language Summary PDF DownloadLoading ...
P‐206L: Late‐News Poster : Low Electric Consumption 3.6W Green SHG Laser Light Source Applicable to Laser Projection Systems (2007)

Abstract Highly‐efficient fully air‐cooled green laser light source with frequency doubling module is reported. As a result, 3.6 watts green laser light generation with about 9% wall‐plug efficiency is achieved. By using fully air‐cooled RGB lasers including the green SHG (Second Harmonic Generation) laser and illumination optics for speckle noise reduction, a laser projection engine is prototyped. A laser rear‐projection system with this laser projection engine shows several merits; wide color gamut (133%NTSC), 61inch large screen size, and low electric power consumption (less than 100W, at 650cd/m 2 ).
HEMEsPred: Structure-Based Ligand-Specific Heme Binding Residues Prediction by Using Fast-Adaptive Ensemble Learning Scheme (2016)

Heme is an essential biomolecule that widely exists in numerous extant organisms. Accurately identifying heme binding residues (HEMEs) is of great importance in disease progression and drug development. In this study, a novel predictor named HEMEsPred was proposed for predicting HEMEs. First, several sequence- and structure-based features, including amino acid composition, motifs, surface preferences, and secondary structure, were collected to construct feature matrices. Second, a novel fast-adaptive ensemble learning scheme was designed to overcome the serious class-imbalance problem as well as to enhance the prediction performance. Third, we further developed ligand-specific models considering that different heme ligands varied significantly in their roles, sizes, and distributions. Statistical test proved the effectiveness of ligand-specific models. Experimental results on benchmark datasets demonstrated good robustness of our proposed method. Furthermore, our method also showed good generalization capability and outperformed many state-of-art predictors on two independent testing datasets. HEMEsPred web server was available at http://www.inforstation.com/HEMEsPred/ for free academic use.