gebhart/patrepeval huggingface dataset:
The Influence of Stress on the Development and Severity of Immune-Mediated Diseases (2011)

Evidence that psychological stress can increase inflammation and worsen the course of immune-mediated inflammatory disease (IMID) is steadily accumulating. The majority of data supporting this hypothesis come from studies in patients with inflammatory bowel disease (IBD). While there is no evidence to suggest that stress is a primary cause of IBD, many, although not all, studies have found that patients with IBD experience increased stress and stressful life events before disease exacerbations. Further, the disease itself can cause psychological stress, creating a vicious cycle. In addition to reviewing the epidemiological evidence supporting a stress-IMID relationship, this article also briefly discusses how stress-related changes in neural, endocrine, and immune functioning may contribute to the pathogenesis of immune diseases, IBD in particular. The effects of different pharmacological and nonpharmacological interventions, including stress management and behavioral therapy, on stress, mood, quality of life (QOL), and activity of the underlying IMID are also summarized.
Supramolecular Assemblies: Exciton Dynamics and Effects of Structural Order in Morphology‐Controlled J‐Aggregate Assemblies (Adv. Funct. Mater. 21/2019) (2019)

In article number 1806997, Rainer F. Mahrt, Jakob Heier, and co-workers report the exciton dynamics of different J-aggregate assemblies grown on a substrate that increases domain size and crystalline order compared to J-aggregates adsorbed from solution. The radiative decay of excitons is significantly enhanced and can be correlated to the increased order. Exciton-charge quenching is identified as an additional non-radiative decay channel impeding exciton migration in J-aggregate thin films.
Electromagnetic Compatibility (EMC) in the Off-Highway Vehicle: Part IV Electronic Design for EMC (1993)

&lt;div class="htmlview paragraph"&gt;Electromagnetic compatibility (EMC) design considerations have a vital role in the proper functioning of the electronic circuits and systems of a modern off-highway vehicle (OHV). Careful planning is needed in developing the electronic systems that operate the various functions and tasks on these vehicles. Incorporation of EMC in a system design gives that system the quality of reliability; that is, the system will have reduced emissions and be less susceptible to radiated and conducted electromagnetic energy. This paper provides ideas, concepts, and guidelines that the designer of OHV control circuitry can use for incorporation of EMC at the beginning of a design project.&lt;/div&gt;
Foveation-based error resilience for video transmission over mobile networks (2002)

We introduce a foveation-based error resilience scheme for low bit rate visual communications over highly error-prone mobile networks. In order to alleviate the degradation of visual quality due to signal fading attenuation, it is necessary to develop more robust error resilience schemes. By maintaining relatively high source throughput for perceptually important regions, the visual quality degradation can be effectively reduced. We spatially divide each frame into foveated and background layers according to perceptual importance. Two bitstreams are generated from the layers and transmitted using an unequal error protection scheme. In the simulation, the visual quality is significantly increased up to 3 dB FPSNR (foveal peak signal to noise ratio) at 40% packet error rate.
Complementary & Alternative Management of Parkinson’s Disease: An Evidence-Based Review of Eastern Influenced Practices (2014)

The prevalence of Parkinson's disease (PD) appears to be lower in Asia compared to the Western world. It is unclear if this is related to the ubiquitous use of traditional medicine in Eastern healthcare, but the use of complementary and alternative medicine (CAM) modalities in countries like Korea may be as high as 76%. Among patients with PD, herbal medicines, health supplement foods, and acupuncture are interventions which are increasingly used throughout the world. Countries like Korea, China, India, and Japan have long embraced and incorporated traditional medicine into modern management of conditions such as PD, but research into various CAM modalities remains in its infancy limiting evidence-based recommendations for many treatments. We reviewed the literature on CAM treatments for PD, focusing on mind-body interventions and natural products. Based on evidence limited to randomized-controlled trials we found that mind-body interventions are generally effective forms of physical activity that are likely to foster good adherence and may reduce disability associated with PD. Based on the current data, modalities like Tai Chi and dance are safe and beneficial in PD, but better studies are needed to assess the effects of other frequently used modalities such as yoga and acupuncture. Furthermore, despite centuries of experience using medicinal herbs and plants in Eastern countries, and despite substantial preclinical data on the beneficial effects of nutritional antioxidants as neuroprotective agents in PD, there is insufficient clinical evidence that any vitamin, food additive, or supplement, can improve motor function or delay disease progression in PD.
Hydrogenation of carboxylic acids with a homogeneous cobalt catalyst (2015)

The reduction of esters and carboxylic acids to alcohols is a highly relevant conversion for the pharmaceutical and fine-chemical industries and for biomass conversion. It is commonly performed using stoichiometric reagents, and the catalytic hydrogenation of the acids previously required precious metals. Here we report the homogeneously catalyzed hydrogenation of carboxylic acids to alcohols using earth-abundant cobalt. This system, which pairs Co(BF4)2·6H2O with a tridentate phosphine ligand, can reduce a wide range of esters and carboxylic acids under relatively mild conditions (100°C, 80 bar H2) and reaches turnover numbers of up to 8000.
11.3: Distinguished Paper : LTPSbased Transparent AM OLED (2010)

Abstract 14.1” qFHD quarter Full High Definition Transparent Active Matrix Organic Light Emitting Display AM OLED was developed with the well known and reliable technology based on LTPS Low Temperature Poly Silicon backplane. The key concept of the transparent AM OLED display lies on the seethrough window on each pixel so that the objects across the device can be seen. In the design of pixel structure, functional separation of light emitting area and seethrough area was realized on the different regions. The features of transparency and transmitted image quality were investigated and optimized in the design of the pixel structure. Up to 38% transparency of the prototype panel was accomplished with the high transparent cathode material which transmittance was more than 75%. LTPS based Active Matrix and Top emission OLED structure was used for the prototype to provide wide range of color expression, more than 100% of color gamut.
Ulnar artery–based free forearm flap: Review of specific anatomic features in 322 cases and related literature (2013)

Considering local anatomic features and variations, the harvest of the UFFF is safe and survival rates are comparable with those of the radial forearm flap.
On the Properties of Next Generation Wireless Backhaul (2022)

With the advent of 5G, cellular networks require a high number of base stations, possibly interconnected with wireless links, an evolution introduced in the last revision of 5G as the Integrated Access and Backhaul (IAB). Researchers are now working to optimize the complex topologies of the backhaul network, using synthetic models for the underlying visibility graph, i.e., the graph of possible connections between the base stations. The goal of this paper is to provide a novel methodology to generate visibility graphs starting from real data (and the data sets themselves together with the source code for their manipulation), in order to base the IAB design and optimization on assumptions that are as close as possible to reality. We introduce a GPU-based method to create visibility graphs from open data, we analyze the properties of the realistic visibility graphs, and we show that different geographic areas produce very different graphs. We run state-of-the-art algorithms to create wireless backhaul networks on top of visibility graphs, and we show that the results that exploit synthetic models are far from those that use our realistic graphs. Our conclusion is that the data-based approach we propose is essential to design mobile networks that work in a variety of real-world situations.
Synthesis and herbicidal activity of new benzenesulfonylurea derivatives possessing bicyclic ketal subgroup (2002)

New benzenesulfonylurea derivatives possessing bicyclic ketal subgroup were synthesized and shown to have interesting herbicidal activities under upland greenhouse screening.
Effect of recombinant human gonadotrophins on human, bovine and murine oocyte meiosis, fertilization and embryonic development in vitro (2000)

The response of murine, bovine and human oocytes to pure recombinant preparations of human follicle stimulating hormone (rFSH) and luteinizing hormone (rLH) for meiotic maturation and subsequent developmental competence in vitro were examined in the present experiments. Maturation of immature bovine oocytes to the metaphase II stage was significantly increased by the addition of 1 IU/ml of rFSH in combination with either 1 IU/ml rLH or 10 IU/ml rLH. Similarly, embryonic development to the blastocyst stage was improved in bovine oocytes treated with a 1:10 combination of rFSH:rLH. However, no significant difference was observed in the number of inner cell mass or trophectoderm cells of the resulting blastocysts. Although the increased maturation to metaphase II was not significant, human embryonic developmental competence was improved by maturing oocytes in the presence of a 1:10 ratio of rFSH:rLH as only those oocytes exposed to a 1:10 ratio of rFSH: rLH during maturation showed normal cleavage patterns beyond day 2. In addition, 1 IU/ml rFSH and 1 IU/ml rLH increased the expression of oocyte proteins in human oocytes. The inclusion of recombinant gonadotrophins, either singly or in combination, had no significant effect on the maturation, fertilization or embryonic development of in-vitro matured mouse oocytes. These data provide support for the responsiveness of human and bovine oocytes to gonadotrophins in vitro and the need to consider variations in the relative concentrations for optimization of oocyte developmental competence.
Isolation and Characterization of a New Member of the Scavenger Receptor Superfamily, Glycoprotein-340 (gp-340), as a Lung Surfactant Protein-D Binding Molecule (1997)

We have purified a previously unknown glycoprotein (designated gp-340) from human bronchioalveolar lung washings from a patient with alveolar proteinosis. gp-340 was identified by its calcium-dependent binding to lung surfactant protein D (SP-D) and by its molecular mass of 340 kDa in the reduced state on SDS-polyacrylamide gel electrophoresis (PAGE). gp-340 was purified from the 10,000 x g pellet of the lavage fluid by ion-exchange and gel permeation chromatography. On SDS-PAGE, gp-340 showed an apparent molecular mass of 290 kDa in the unreduced state. On gel chromatography under non-dissociating conditions, the apparent molecular mass of gp-340 was >1000 kDa. The presence of N-linked glycosylation was shown by digestion with N-glycosidase F, which reduced the apparent molecular mass of gp-340 under reducing condition to about 300 kDa. Partial amino acid sequence data showed the presence of scavenger-receptor type domains. Monoclonal and polyclonal antibodies were raised against gp-340, and their specificities were confirmed by Western blotting. The antibodies were used for immunohistochemical localization of gp-340 in the lung, where it was found on the surface of and within alveolar macrophages. Direct binding between gp-340 and SP-D took place at physiological ionic strength, required the presence of calcium, and was not inhibited by maltose. The binding between SP-D and mannan also required the presence of calcium, but this interaction was completely inhibited by maltose. The same binding pattern was seen between gp-340 and recombinant human SP-D composed of the trimeric neck region and three carbohydrate recognition domains. These findings indicate that the binding between gp-340 and SP-D is a protein-protein interaction rather than a lectin-carbohydrate interaction and that the binding to gp-340 takes place via the carbohydrate recognition domain of SP-D. We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D.
Alkylation with a Hydrogenating Catalyst (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation with a Hydrogenating CatalystV. I. KomarewskyCite this: J. Am. Chem. Soc. 1937, 59, 12, 2715–2716Publication Date (Print):December 1, 1937Publication History Published online1 May 2002Published inissue 1 December 1937https://pubs.acs.org/doi/10.1021/ja01291a072https://doi.org/10.1021/ja01291a072research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidative addition of halogens and pseudohalogens to dihalo(1,10-phenanthroline)platinum(II) (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative addition of halogens and pseudohalogens to dihalo(1,10-phenanthroline)platinum(II)Keith D. Hodges and John V. RundCite this: Inorg. Chem. 1975, 14, 3, 525–528Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/ic50145a015https://doi.org/10.1021/ic50145a015research-articleACS PublicationsRequest reuse permissionsArticle Views857Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electronic structure of GaN and Ga investigated by soft x-ray spectroscopy and first-principles methods (2010)

The electronic structure and chemical bonding of wurtzite-GaN investigated by $\text{N}\text{ }1s$ soft x-ray absorption spectroscopy and $\text{N}\text{ }K$, $\text{Ga}\text{ }{M}_{1}$, and $\text{Ga}\text{ }{M}_{2,3}$ emission spectroscopy is compared to that of pure Ga. The measurements are interpreted by calculated spectra using first-principles density-functional theory (DFT) including dipole transition matrix elements and additional on-site Coulomb interaction $(\text{WC-GGA}+U)$. The $\text{Ga}\text{ }4p\text{-N}\text{ }2p$ and $\text{Ga}\text{ }4s\text{-N}\text{ }2p$ hybridization and chemical bond regions are identified at the top of the valence band between $\ensuremath{-}1.0$ and $\ensuremath{-}2.0$ and further down between $\ensuremath{-}5.5$ and $\ensuremath{-}6.5\text{ }\text{eV}$, respectively. In addition, $\text{N}\text{ }2s\text{-N}\text{ }2p\text{-Ga}\text{ }4s$ and $\text{N}\text{ }2s\text{-N}\text{ }2p\text{-Ga}\text{ }3d$ hybridization regions occur at the bottom of the valence band between $\ensuremath{-}13$ and $\ensuremath{-}15\text{ }\text{eV}$, and between $\ensuremath{-}17.0$ and $\ensuremath{-}18.0\text{ }\text{eV}$, respectively. A bandlike satellite feature is also found around $\ensuremath{-}10\text{ }\text{eV}$ in the $\text{Ga}\text{ }{M}_{1}$ and $\text{Ga}\text{ }{M}_{2,3}$ emission from GaN, but is absent in pure Ga and the calculated ground-state spectra. The difference between the identified spectroscopic features of GaN and Ga are discussed in relation to the various hybridization regions calculated within band-structure methods.
Proton Magnetic Resonance Spectroscopy as a Probe into the Pathophysiology ofAutismSpectrumDisorders (ASD): A Review (2013)

Proton magnetic resonance spectroscopy ((1) H-MRS) is a safe, noninvasive way of quantifying in vivo biochemical and metabolite concentration levels in individuals with Autism Spectrum Disorders (ASD). Findings to date suggest ASD is associated with widespread reduction in N-acetylaspartate (NAA), creatine plus phosphocreatine (Cr), choline-containing compounds (Cho), myo-inositol (mI), and glutamate plus glutamine plus gamma-Aminobutyric Acid (Glx); however, variable findings, and even substantial increases, are not uncommon depending on the study and/or region-of-interest. Widespread reduction of NAA, Cr, Cho, mI, and Glx in ASD likely reflects impaired neuronal function and/or metabolism related to abnormal neurodevelopmental processes. Future studies should attempt to relate (1) H-MRS findings to histological findings and control for variability in subject age and functioning level; this would assist in evaluating the relationship between (1) H-MRS metabolic levels and neuronal and glial cell densities, as well as neurodevelopmental process associated with ASD. Furthermore, more longitudinal (1) H-MRS studies are needed in both control and ASD subjects to attempt to standardize metabolite levels across different developmental periods in well-defined endophenotypes. This will provide for a standard rubric for which metabolic aberrations (as well as treatment responses) can be measured. With higher magnetic field strengths and spectral-editing techniques capable of quantifying less-concentrated metabolites, (1) H-MRS will continue to be an important tool in ASD research.
A Network-Fusion Guided Dashboard Interface for Task-Centric Document Curation (2017)

Knowledge workers are being exposed to more information than ever before, as well as having to work in multi-tasking and collaborative environments. There is an increasing need for interfaces and algorithms to help automatically keep track of documents that are associated with both individual and team tasks. Previous approaches to the problem of automatically applying task labels to documents have been limited to small feature spaces or have not taken into account multi-user environments. Many different clues to potential task associations are available through user, task and document similarity metrics, as well as through temporal patterns in individual and team workflows. We present a network-fusion algorithm for automatic task-centric document curation, and show how this can guide a recent-work dashboard interface, which organizes user's documents and gathers feedback from them. Our approach efficiently computes representations of users, tasks and documents in a common vector space, and can easily take into account many different types of associations through the creation of edges in a multi-layer graph. We have demonstrated the effectiveness of this approach using labelled document corpora from three empirical studies with students and intelligence analysts. We have also shown how to leverage relationships between different entity types to increase classification accuracy by up to 20% over a simpler baseline, and with as little as 10% labelled data.
Supplementary Materials and Methods from Entrectinib, a Pan–TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications (2023)

&lt;p&gt;Supplementary experimental procedures are described&lt;/p&gt;
Approximation stochastique distribuée : le coût de la non-bistochasticité (2013)

National audience
Easing the Pain of Procurement (1986)

The difficulty in procuring for America an arsenal adequate to ensure national security at the lowest possible price is no more insolvable than dozens of other problems the American people face. Critics of the procurement process too often fail to understand, though, that the business of supplying our nation's defense needs cannot be analyzed in exactly the same terms as, for example, the business of supplying consumer goods - or even most commercial goods and services. The purchase of a hammer from a defense contractor may in fact be a different kind of transaction than the purchase of a hammer from a hardware store. How it is different - and whether it should be different - is at the heart of the defense procurement debate. Understanding the differences will point the way toward potential solutions of very real problems.
Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication. (1994)

We have previously shown that depletion of TCR-V beta 8+ T cells by treatment with mAb reduces the curative effectiveness of low dose melphalan (L-phenylalanine mustard; L-PAM) for mice bearing a large MOPC-315 tumor and extensive metastases. Here we show that V beta 8+/CD8+ T cell lines derived from mice that are in the process of immune-mediated eradication of a large MOPC-315 tumor as a consequence of low dose L-PAM therapy (L-PAM TuB mice) are capable of mediating tumor eradication in vivo upon adoptive transfer. Analysis of the possible mechanisms through which these cell lines bring about tumor eradication revealed that the V beta 8+/CD8+ cells can exert in vitro a potent lytic activity and secrete large amounts of IFN-gamma. Both of these activities can be triggered by the MOPC-315 but not the MOPC-104E plasmacytoma and are restricted by the MHC class I H-2Kd molecule. In vivo neutralization of IFN-gamma by treatment with mAb was found to cause a noticeable delay in tumor rejection in mice subjected to adoptive chemoimmunotherapy with low dose L-PAM and V beta 8+/CD8+ cells; however, all tumors did regress after initial growth. Thus, the V beta 8+/CD8+ cells use an IFN-gamma-dependent mechanism for the realization of their in vivo tumor-eradicating immunity. However, an IFN-gamma-independent mechanism, most likely involving direct V beta 8+/CD8+ CTL activity, is apparently also used.
La trama de la identidad en el País Valenciano: un estudio de identidades colectivas (1994)

Psoas density is significantly decreased in patients with Clavien-Dindo grade III-V complications after curative resection for colon and rectal cancer. Due to the simplicity and affordability of its assessment from preoperative staging CT scan, it might be considered an optimal sarcopaenic indicator to be utilised in everyday practice.