gebhart/patrepeval huggingface dataset:
Subunit VII of ubiquinol:cytochrome-c oxidoreductase from Neurospora crassa is functional in yeast and has an N-terminal extension that is not essential for mitochondrial targeting (1996)

cDNA clones encoding subunit VII of the Neurospora crassa bc1 complex (ubiquinol:cytochrome-c oxidoreductase), which is homologous with subunit VIII of the complex from yeast (encoded by QCR8), were identified on the basis of functional complementation of a yeast QCR8 deletion strain. The clones contain an open reading frame encoding a protein with a calculated molecular mass of 11.8 kDa. The N-terminal eight residues of the amino acid sequence deduced from the cDNA clones are absent from the mature protein, as revealed by direct sequencing of the isolated protein. To investigate the potential role of the N-terminal octapeptide in mitochondrial targeting, constructs were made encoding the precursor and the mature form of subunit VII from Neurospora. Incubation of isolated mitochondria with the two proteins revealed that the N-terminal extension of the precursor is removed on import. However, the presequence does not encode information for targeting, as the proteins encoded by both constructs can be imported into isolated mitochondria with equal efficiency. In contrast, the octapeptide seems to have functional importance: the defect in the yeast qcr8-null mutant is not complemented on transformation with the construct encoding mature subunit VII from N. crassa in a single-copy plasmid. We therefore speculate that the N-terminal extension plays a role in intramitochondrial sorting of N. crassa subunit VII. This is supported by the fact that the subunit VII precursor is processed by a protease other than the general mitochondrial processing peptidase. Interestingly, the presequence of N. crassa subunit VII has an amino acid composition similar to the octapeptides cleaved off by the mitochondrial intermediate peptidase.
Muscle Flexes Smart Cards into Linux (1998)

The newest kind of card for your pocketbook offers better security for the information it holds
Cytotoxicity of Biochar: A Workplace Safety Concern? (2017)

Biochar has a number of environmental applications, including soil amendment for agriculture, remediation of contaminated soils and sediments, and climate change mitigation. Dust formed during its production and field application may pose a health risk, but the cytotoxicity of biochar has, to the best of our knowledge, not previously been investigated. Therefore, we measured the concentration-dependent cytotoxicity of biochar on an NIH 3T3 mouse fibroblast cell line. We used a contaminant trap experiment to measure the total and nondesorbable polycyclic aromatic hydrocarbon (PAH) fractions of the biochar. PAH release was found to be negligible because of the biochar’s strong PAH sorption potential. The biochar was nevertheless observed to have a cytotoxic effect on the fibroblast cells; the EC10 values were 49.6 and 18.8 μg/mL after incubation for 24 and 48 h, respectively. This cytotoxic effect is likely to relate to the particulate nature and size distribution of the biochar; the biochar had particles similar in size to atmospheric particulate matter (PM2.5) that bound to the fibroblast cell surface. To minimize the risk of exposure, practitioners should wear respiratory protective equipment during biochar production. During field application, biochar should be applied in slurries and should always be mixed with a soil matrix to avoid secondary dust formation.
Muscarinic Agonists as Insecticides and Acaricides (1997)

A series of known agonists of the mammalian muscarinic receptor were prepared and evaluated for their insecticidal potential. It was discovered that pests such as Nilaparvata lugens (brown planthopper), Nephotettix cincticeps (green leafhopper), Tetranychus urticae (two-spotted spider mite) and Aphis gossypii (cotton aphid) were particularly sensitive to most of these compounds. Several analogs proved to be extremely active, surpassing commercial standards in some of the laboratory bioassays. These compounds exhibited a range of potencies for the insect (Musca) muscarinic receptor. Addition of GTP significantly reduced the affinity of the most potent analog for the Musca mAChR, indicating the compound functions as an agonist in insect tissue. Regression analysis indicated that significant relationships exist between displacement of [3H]QNB at the Musca muscarinic receptor and whole organism toxicity to three insect and one mite species. The results suggested that the insect muscarinic receptor represents a viable target site for insecticidal action. © 1997 SCI.
Infected suture anchors in the shoulder (1996)

Symptomatic anterior glenohumeral instability secondary to a Bankart lesion may require surgical reconstruction and repair of labral pathology. In this report, a Bankart repair was performed using metallic suture anchors. An infection developed around the anchors necessitating their removal. To our knowledge, this is the first report of an infection associated with a suture anchor device.
An Analysis of Service Bundles of Mobile Network Operators with Free Services Included (2019)

To attract more users, mobile network operators may offer both chargeable/metered and free services as parts of their product bundles. However, an extra cost of providing the free services and their substitution effect on metered services in the bundles may reduce their profitability. Therefore, the mobile network operators must decide on including free services in their offered bundles based on the profitability. In this paper, we develop an analytical framework composed of leader-follower game models to obtain the Stackelberg equilibrium strategy of the mobile network operators and analyze several important properties of the equilibrium. The proposed framework takes into account the congestion effect resulting from incorporating free services in the bundles. The game models are general and capable of analyzing different setting of bundles. Extensive performance evaluations show that the inclusion of free services can improve the profit of the mobile network operators when (i) the users' interest for the free services is above a certain value, (ii) the free services add small cost to the bundle, and (iii) the users' demand of free services is less dependent on that of metered services in the bundle.
Abstract 20993: Role of Noncoding scaRNA20 in Differentiation of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (2017)

Introduction: Studies have shown that mRNA splicing is regulated by scaRNAs and plays a significant role in mammalian cardiac development and differentiation, but the potential contribution to human in vitro differentiation of iPSCs into CMCs remains unknown. In this study, the comparison of scaRNA20 modified and unmodified iPSCs derived-CMCs (iCMCs) will allow us to understand the role of scaRNAs in cardiac differentiation. Hypothesis: We hypothesize that CMCs modulated with scaRNA20 plays an important role in iPSCs-derived CMC differentiation. Methods and Results: Recently, our RNA sequencing analysis of iCMCs indicated that scaRNA20 plays an important role in CMC differentiation. We observed that si-scaRNA20 knockdown iPSCs underwent CMCs differentiation. They failed to grow as mature functional CMCs ( Fig. A ) and the number of beating clusters were reduced compared to the scrambled control cells (Fig. B). Our FACS data showed that there was a significant reduction in the expression of Gata4 and CTT in the CMC-derived from iPSCs kockdown with si-scaRNA20-1 but not in those with si-scaRNA-2 (Fig. C) . Similarly, our FACS data from scaRNA20 overexpressing iPSCs differentiated into CMCs showed a significant increase in the number of Gata4- and CTT-expressing cells, suggesting the role of scaRNA20 in CMC differentiation. Conclusions: We report for the first time the role scaRNA20 in the regulation of in-vitro cardiac development.
ChemInform Abstract: The Use of Soluble Polymers to Effect Homogeneous Catalyst Separation and Reuse (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Plasmodium falciparum Antigen that Binds to Host Erythrocytes and Merozoites (1985)

Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malaria parasite (Plasmodium falciparum). A 175-kilodalton (175K) antigen bound only to erythrocytes susceptible to invasion. The 175K antigen from the Camp or the FCR-3 strain also bound to merozoites. However, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invaded normally by merozoites of the homologous strain but were partially resistant to invasion by merozoites of the heterologous strain. The 175K antigen may be a receptor acting as a "bridge" between erythrocytes and merozoites.
Large-area electronics combined with integrated circuits into a strain sensing sheets (2015)

&lt;p&gt;The strain sensing sheet based on Large Area Electronics (LAE) and Integrated Circuits (ICs) is being researched and developed at Princeton University. The prototypes of components of the sensing sheet including LAE interconnect, embedded sensors, batteries, and power harvesters have been created. Behaviour of the sensor exposed to damage has been studied and characterized. Probabilistic algorithms have been created for both data interpretation and evaluation of probability of detection. Small-scale and large-scale tests have been successfully carried out in order to evaluate the concept of the strain sensing sheet and understand its behavior under conditions of damage occurrence and propagation. The concept of the strain sensing sheet, test results, and its current state of advancement are presented in this paper.&lt;/p&gt;
Biological model of Zebrafish‐ a new research trend in ophthalmology, for an antiangiogenic treatment (2017)

Purpose Zebrafish is an ideal biological model for studying human diseases because of many similarities with the human genome. The structure of zebrafish eye is also very comparable to the human eye. We focused on new therapies for wet age‐related macular degeneration ( wAMD ) and proliferative diabetic retinopathy ( PDR ). The aim of the study was to present the influence of dopamine's agonist on the angiogegesis of Zebrafish larvae in comparison with anti‐angiogenic effect of bevacizumab Methods 3 substances were used: bromocriptine, pergolide, cabergoline in concentrations from 1 nmol to 2,5 umol. Process of angiogenesis was observed for 5 days in larvae of genetically modified Zebrafish Fli with labelled, luminescent blood vessels. Photo documentation was taken under the fluorescent microscope Stereo discover v8, fluorescence 200c hxp. Carl Zeiss Microscopy GmbH. Results Tested substances had inhibitive impact on process of angiogenesis in Zebrafish larvae. The strongest one was pergolide. We observed the diferences in Zebrafish vessels. Patological vessels were observed not only in the retina but also in the whole body of Zebrafish. Conclusions Zebrafish is getting more and more common model for pharmacologic research. Inhibition of angiogenesis by dopamine's agonist may be new therapeutic option in treatment of diseases, complicated by neovascularization like AMD and proliferative diabetic retinopathy.
A Multi-Disciplinary Perspective on Platform Ecosystems Research (2017)

Platform ecosystems (e.g., Apple iOS, Sony PlayStation, Amazon) are receiving increasing attention from scholars in various subfields including strategy, innovation, information systems, and entrepreneurship. Nevertheless, each of these fields has their own set of definitions, research questions, and research agendas which can cause incongruence and silo-thinking. This panel symposium attempts to initiate a cross- disciplinary conversation and improve our understanding of platform ecosystems. Our goals are 1) to understand common features of platform ecosystems, 2) to learn about state of the art research on platform ecosystems from various subfields, and 3) identify opportunities for cross-disciplinary research that pushes the envelope of platforms research. We accomplish these goals by bringing together four high-profile platform scholars from the strategic management, innovation, information systems, and entrepreneurship fields. We further work with a senior scholar who is well-positioned to cut across disciplinary silos and moderate a constructive discussion on platform ecosystem research.
Photolithography Fabricated Sub-Decibel High-Efficiency Silicon Waveguide Grating Coupler (2022)

Using the optimized shift-pattern overlay method, we present a new high-efficiency silicon waveguide grating coupler operating at 1550 nm center wavelength, which has a simulation predicted coupling loss of 0.68 dB and experimentally measured loss of 0.89 dB. This record result was achieved without any substrate bottom mirrors or use of electron beam lithography and was fabricated with the standard processes of a multi-project wafer fabrication service from a commercial foundry.
Effect of Frame Aggregation on the Throughput Performance of IEEE 802.11n (2008)

The IEEE 802.11n standard aims at providing a data transmission rate of up to 600 Mbps. The frame aggregation techniques of IEEE 802.11n MAC layer play an important role in the enhancement of channel utilization. In this paper, we investigate the effect of IEEE 802.11n frame aggregation for two aggregation mechanisms: MAC protocol data unit aggregation (A-MPDU) and MAC service data unit aggregation (A-MSDU). We propose an analytical model based on an enhanced discrete time Markov chain (DTMC) model in order to describe the post- backoff behavior due to frame aggregation, and then evaluate the throughput performance. Analytical results based on the mathematical model are verified through simulation. The throughput performance of the A-MSDU mechanism outperforms the A-MPDU mechanism as the frame aggregation size becomes larger under an error-free environment. In addition, the throughput performance is significantly improved as the frame aggregation size increases.
Basket Recommendation with Multi-Intent Translation Graph Neural Network (2020)

The problem of basket recommendation~(BR) is to recommend a ranking list of items to the current basket. Existing methods solve this problem by assuming the items within the same basket are correlated by one semantic relation, thus optimizing the item embeddings. However, this assumption breaks when there exist multiple intents within a basket. For example, assuming a basket contains \{\textit{bread, cereal, yogurt, soap, detergent}\} where \{\textit{bread, cereal, yogurt}\} are correlated through the "breakfast" intent, while \{\textit{soap, detergent}\} are of "cleaning" intent, ignoring multiple relations among the items spoils the ability of the model to learn the embeddings. To resolve this issue, it is required to discover the intents within the basket. However, retrieving a multi-intent pattern is rather challenging, as intents are latent within the basket. Additionally, intents within the basket may also be correlated. Moreover, discovering a multi-intent pattern requires modeling high-order interactions, as the intents across different baskets are also correlated. To this end, we propose a new framework named as \textbf{M}ulti-\textbf{I}ntent \textbf{T}ranslation \textbf{G}raph \textbf{N}eural \textbf{N}etwork~({\textbf{MITGNN}}). MITGNN models $T$ intents as tail entities translated from one corresponding basket embedding via $T$ relation vectors. The relation vectors are learned through multi-head aggregators to handle user and item information. Additionally, MITGNN propagates multiple intents across our defined basket graph to learn the embeddings of users and items by aggregating neighbors. Extensive experiments on two real-world datasets prove the effectiveness of our proposed model on both transductive and inductive BR. The code is available online at https://github.com/JimLiu96/MITGNN.
Magnetic imaging by ‘‘force microscopy’’ with 1000 Å resolution (1987)

We describe a new method for imaging magnetic fields with 1000 Å resolution. The technique is based on using a force microscope to measure the magnetic force between a magnetized tip and the scanned surface. The method shows promise for the high-resolution mapping of both static and dynamic magnetic fields.
Exogenous Tissue Plasminogen Activator Enhances Peripheral Nerve Regeneration and Functional Recovery After Injury In Mice (2006)

Tissue plasminogen activator (tPA) is an essential component of the proteolytic cascade that lyses blood clots. Various studies also suggest that tPA plays important roles in the nervous system. We show that exogenous tPA or tPA/plasminogen (plg) promotes axonal regeneration, remyelination, and functional recovery after sciatic nerve injury in the mouse. Local application of tPA or tPA/plg 7 days after sciatic nerve crush significantly increased the total number of axons and myelinated axons, which is accompanied by enhanced expression of neurofilament. Treatment with tPA or tPA/plg reduced the deposition of fibrin(ogen) after nerve injury. Moreover, tPA or tPA/plg increased the number of macrophages and induced MMP-9 expression at the injury site, coincident with reduced collagen scar formation and accelerated clearance of myelin and lipid debris after treatment. Consequently, tPA or tPA/plg treatment protected muscles from atrophy after nerve injury, indicating better functional recovery. These results suggest that administration of exogenous tPA or tPA/plg promotes axonal regeneration and remyelination through removal of fibrin deposition and activation of MMP-9-positive macrophages, which may be responsible for myelin debris clearance and preventing collagen scar formation. Therefore, tPA may be useful for treatment of peripheral nerve injury.
Perovskite Solar Cells: From the Atomic Level to Film Quality and Device Performance (2017)

Organic-inorganic perovskites have made tremendous progress in recent years due to exceptional material properties such as high panchromatic absorption, charge carrier diffusion lengths, and a sharp optical band edge. The combination of high-quality semiconductor performance with low-cost deposition techniques seems to be a match made in heaven, creating great excitement far beyond academic ivory towers. This is particularly true for perovskite solar cells (PSCs) that have shown unprecedented gains in efficiency and stability over a time span of just five years. Now there are serious efforts for commercialization with the hope that PSCs can make a major impact in generating inexpensive, sustainable solar electricity. In this Review, we will focus on perovskite material properties as well as on devices from the atomic to the thin film level to highlight the remaining challenges and to anticipate the future developments of PSCs.
Taskonomy: Disentangling Task Transfer Learning (2018)

Do visual tasks have relationships, or are they unrelated? For instance, could having surface normals simplify estimating the depth of an image? Intuition answers these questions positively, implying existence of a certain structure among visual tasks. Knowing this structure has notable values; it provides a principled way for identifying relationships across tasks, for instance, in order to reuse supervision among tasks with redundancies or solve many tasks in one system without piling up the complexity. We propose a fully computational approach for modeling the transfer learning structure of the space of visual tasks. This is done via finding transfer learning dependencies across tasks in a dictionary of twenty-six 2D, 2.5D, 3D, and semantic tasks. The product is a computational taxonomic map among tasks for transfer learning, and we exploit it to reduce the demand for labeled data. For example, we show that the total number of labeled datapoints needed for solving a set of 10 tasks can be reduced by roughly 2/3 (compared to training independently) while keeping the performance nearly the same. We provide a set of tools for computing and visualizing this taxonomical structure at http://taskonomy.vision.
A Developmental Analysis of Seed Size in Common Bean1 (1979)

A comparative, developmental analysis of seed size was made between two cultivars of common bean ( Phaseolus vulgaris L.) with contrasting mature seed sizes. The seed of large‐seeded cultivar ‘Taylor's Horticultural’ is smaller than that of small‐seeded cultivar P.I. 226895 from anthesis to day 20, and this relationship is reversed from day 20 to maturation. This pattern of relative size relationship is manifested by the whole seed and by both major components of the seed (embryo and seed coat). Length, weight, and volume were the parameters measured to determine seed size; measurements of all three were continued throughout development of the seed.
Human Immunodeficiency Virus Type 1 Entry Inhibitors PRO 542 and T‐20 Are Potently Synergistic in Blocking Virus‐Cell and Cell‐Cell Fusion (2001)

Human immunodeficiency virus type 1 (HIV-1) entry proceeds via a cascade of events that afford promising targets for therapy. PRO 542 neutralizes HIV-1 by blocking its attachment to CD4 cells, and T-20 blocks gp41-mediated fusion. Both drugs have shown promise in phase 1/2 clinical trials. Here, the drugs were tested individually and in combination in preclinical models of HIV-1 infection, and inhibition data were analyzed for cooperativity by using the combination index method. Synergistic inhibition of virus-cell and cell-cell fusion was observed for phenotypically diverse viruses for a broad range of drug concentrations, often resulting in > or = 10-fold dose reductions in vitro. Additional mechanism-of-action studies probed the molecular basis of the synergies. The markedly enhanced activity observed for the PRO 542:T-20 combination indicates that the multistep nature of HIV-1 entry leaves the virus particularly vulnerable to combinations of entry inhibitors. These findings provide a strong rationale for evaluating combinations of these promising agents for therapy in vivo.
Semaglutide for the treatment of non-alcoholic steatohepatitis: Trial design and comparison of non-invasive biomarkers (2020)

Non-alcoholic steatohepatitis (NASH) is a chronic liver disease. There is a clear need to develop pharmacological treatment for patients with NASH as well as biomarkers that can diagnose the disease. We describe a trial of semaglutide treatment for NASH, identify key patient characteristics and compare the relationship of patient characteristics and non-invasive biomarkers/scores. NCT02970942 is a randomised, double-blind, placebo-controlled, multi-national Phase 2 trial of daily subcutaneous semaglutide (0.1 mg, 0.2 mg, 0.4 mg) in patients with biopsy-confirmed NASH, F1-F3 fibrosis, NAFLD Activity Score ≥ 4, and body mass index (BMI) > 25 kg/m<sup>2</sup>. Exploratory analyses were performed to evaluate correlations between baseline parameters and biomarkers in NASH. Mean (standard deviation [SD]) age of 320 randomised patients was 55 (11) years, mean BMI was 36 (6) kg/m<sup>2</sup>, and 199 (62%) had type 2 diabetes. Of the total patients, 28% had F1 fibrosis, 23% had F2 fibrosis and 49% had F3 fibrosis. The highest area under the receiver operating characteristic curve (0.69) for accuracy in classifying fibrosis stage, F2-3 versus F1, was observed for Fib-4 and Enhanced Liver Fibrosis (ELF). No substantial correlation between BMI or other clinical or biochemical parameters and fibrosis stage was observed. In this large Phase 2 trial of semaglutide treatment for NASH, the clinical profile of enrolled patients was typical for patients with NASH. Of the investigated biomarkers/scores, ELF and Fib-4 showed the most apparent correlation in classifying fibrosis stage, but had only moderate predictive value.