gebhart/patrepeval huggingface dataset:
Prosody and phonemes (2013)

The benefit of prosodic and additional spectral over exclusively cepstral feature information is investigated for the recognition of phonemes in eight different speaking styles reaching from informal to formal. As prosodic information is best analyzed on a supra-segmental level, the whole temporal context of a phoneme is exploited by application of statistical functionals. 521 acoustic features are likewise obtained and evaluated per descriptor and functional by either de-correlating floating search feature evaluation or classification performance: The classifier of choice are Support Vector Machines lately found highly suitable for this task. As database serves the open IFA corpus of 178 k hand-segmented and hand-labeled 47 Dutch phonemes. In the result, a significant gain is observed for segment-based over frame-based processing, and by inclusion of pitch and formant information for the informal styles. Overall, phonemes are recognized at 76.58% accuracy. The analysis of feature influence provides useful insight for artificial speech production in the considered speaking styles.
Met-RANTES Inhibition of Mucosal Perfusion Failure in Acute Intestinal Transplant Rejection – Role of Endothelial Cell-Leukocyte Interaction (2002)

Acute rejection-induced microvascular injury results in graft dysfunction, ultimately leading to graft loss. Infiltration of T cells and monocytes as a consequence of an enhanced endothelial cell-leukocyte interaction appears to play an important role in this deleterious process. Recruitment of these pro-inflammatory cells to the vessel wall is mediated by chemokines such as RANTES. Heterotopic small bowel transplantation was performed in rats with the fully allogeneic Brown Norway-Lewis strain combination and, as a control, the syngeneic Lewis-Lewis strain combination. Intravital microscopy was performed from postoperative day 1-7 in both groups. The percentages of perfused villi and villus stasis, mucosal and muscular functional capillary densities, red blood cell velocities, and finally, firm adherence of leukocytes in postcapillary submucosal venules were assessed. Syngeneic small bowel transplantation revealed homogeneous perfusion of villi and muscle layers over the whole study period. Allogeneic small bowel transplantation showed a decline in perfusion from postoperative day 1 until complete failure on postoperative day 7. This was accompanied by a continuous increase in endothelial cell-leukocyte interaction which reached a plateau on postoperative day 5. Met-RANTES treatment at 200 microg/day for 5 days markedly attenuated both the decrease in functional capillary density and the increased endothelial cell-leukocyte interaction in rats following allogeneic small bowel transplantation. We conclude that blocking chemokine receptors, thereby limiting endothelial cell-leukocyte interaction, may constitute a useful therapeutic approach to the prevention of microcirculatory perfusion failure in acute transplant rejection.
Dissolution Kinetics of International Simple Glass and Formation of Secondary Phases at Very High Surface Area to Solution Ratio in Young Cement Water (2021)

Static dissolution experiments were carried out with the reference International Simple Glass under hyperalkaline pH at 70 °C and very high SA/V ratio. Three aspects of glass dissolution behavior were investigated, (1) the rate drop regime and the residual rate (stage II), (2) the formation of secondary phases including thermodynamic aspects, and (3) the microstructure of the interface of altered glass and secondary phases. A very low residual rate of 6 × 10<sup>-6</sup> g/m<sup>2</sup>d was determined based on boron release, which was several orders of magnitude lower than the initial rate established between the start of the experiments and the first sampling on day 59. The presence of a porous layer with a thickness varying between 80 nm and 250 nm and a pore size between 10 nm and 50 nm was observed. CSH phases with a low Ca/Si ratio of 0.3-0.4 and zeolites were also visible at the surface of the altered glass grains, but no glass alteration resumption occurred, probably due to an important pH decrease already at day 59. Thermodynamic calculations assuming congruent glass dissolution and precipitation of the dissolved aqueous species confirmed the precipitation of CSH phases and zeolites.
Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. (1996)

In inflammatory and neoplastic disorders of the colon a defect barrier function of the mucosa may result in absorption of bacterial products from the intestinal lumen. These products may further recruit inflammatory cells and thus augment the inflammatory response. A novel lipocalin in neutrophils, neutrophil gelatinase associated lipocalin (NGAL), with the ability to bind bacterial formylpeptides, has been described and therefore it is of interest to investigate the expression of this protein in diseases of the colon. Expression of NGAL was investigated by immunohistochemistry and by mRNA in situ hybridisation in normal colon and in neoplastic and inflammatory colorectal diseases. A very high expression of NGAL was seen in colonic epithelium in areas of inflammation, both in non-malignant epithelium (diverticulitis, inflammatory bowel disease, and appendicitis) as well as in premalignant and malignant neoplastic lesions of the colon. In adenocarcinoma, the NGAL expression was especially abundant in the transitional mucosa and in the superficial ulcerated area. On the other hand, no NGAL expression could be detected in lymph node metastases from these adenocarcinomas. A weak expression of NGAL in some epithelial cells was only occasionally seen in normal colon. In conclusion, NGAL synthesis is induced in epithelial cells in inflammatory and neoplastic, colorectal diseases. NGAL may serve an important anti-inflammatory function as a scavenger of bacterial products.
Temperature Sensing in Modular Microfluidic Architectures (2016)

A discrete microfluidic element with integrated thermal sensor was fabricated and demonstrated as an effective probe for process monitoring and prototyping. Elements were constructed using stereolithography and market-available glass-bodied thermistors within the modular, standardized framework of previous discrete microfluidic elements demonstrated in the literature. Flow rate-dependent response due to sensor self-heating and microchannel heating and cooling was characterized and shown to be linear in typical laboratory conditions. An acid-base neutralization reaction was performed in a continuous flow setting to demonstrate applicability in process management: the ratio of solution flow rates was varied to locate the equivalence point in a titration, closely matching expected results. This element potentially enables complex, three-dimensional microfluidic architectures with real-time temperature feedback and flow rate sensing, without application specificity or restriction to planar channel routing formats.
A high speed CORDIC algorithm (2002)

The CORDIC algorithm is a special purpose algorithm which can get an accurate result for trigonometric and hyperbolic functions with a limited number of simple iteration. We modify the classic algorithm to reduce the number of iterations which reduces rounding noise. The modified algorithm is illustrated and simulation results are presented.
Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study (2023)

The application of ClinGen criteria to CHD candidate genes yielded a list that can be used to interpret clinical genetic testing for CHD. Applying this gene list to one of the largest research cohorts of CHD participants provides a lower bound for the yield of genetic testing in CHD.
Investigation of theBRAFV600E Mutation by Pyrosequencing in Lymphoproliferative Disorders (2012)

The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas. However, many uncommon subtypes of lymphoma have not been studied. We designed a BRAF pyrosequencing assay specific for the V600E mutation, which has a sensitivity of 5% and is applicable to paraffin-embedded tissue. DNA was sequenced in 9 cases of HCL; 6 cases of variant HCL; 10 cases each of nodal marginal zone lymphoma (NMZL), extranodal marginal zone lymphoma (ENMZL), posttransplantation lymphoproliferative disorder (PTLD), and large granular lymphocyte (LGL) proliferations; 11 cases of peripheral T-cell lymphoma (PTCL); and 12 cases of anaplastic large cell lymphoma (ALCL). All (100%) cases of HCL were positive for BRAF mutations. No mutations were identified in variant HCL, NMZL, ENMZL, PTLD, PTCL, ALCL, or LGL proliferations. Among lymphoproliferative disorders, BRAF mutations are restricted to HCL.
Non-equilibrium LO and TO phonon generation by electron transport in Terahertz quantum cascade lasers (2010)

We report on the experimental observation of non-equilibrium longitudinal and transverse optical phonons populations associated with electron transport in resonant-phonon THz quantum-cascade lasers and compare the results with the outcome of Monte Carlo simulations.
CLINICOPATHOLOGICAL FEATURES OF RESECTED HILAR CARCINOMA OF THE BILE DUCT (1993)

Between 1983 and 1992, surgical intervention was attempted in 14 patients with hilar carcinoma of the bile duct. Local excision of the lesion alone was performed in four patients and hepatic resection in 10, in nine of whom resection of the caudate lobe was also undertaken. The histological free margin was observed in only five of 10 patients with hepatic resection (microscopic curative resection rate, 35.7%). The positive rate of surgical margins was 21% on the duodenal side, 36% on the resected side, 50% on the hepatic side and 21% on the paraaortic lymph-nodes. The modified Bismuth-Corlette classification was useful for selection of the type of surgical intervention in hilar carcinoma of the bile duct. It is suggested that rational resection of the bile duct including hepatectomy and extensive lymphadenectomy is necessary for widening the radical resection and to improve the surgical outcome of hilar carcinoma of the bile duct.
A high-density transcript linkage map with 1,845 expressed genes positioned by microarray-based Single Feature Polymorphisms (SFP) in Eucalyptus (2011)

The Eucalyptus 1,845 gene map is the most highly enriched map for transcriptional information for any forest tree species to date. It represents a major improvement on the number of genes previously positioned on Eucalyptus maps and provides an initial glimpse at the gene space for this global tree genome. A general protocol is proposed to build high-density transcript linkage maps in less characterized plant species by SFP genotyping with a concurrent objective of reducing microarray costs. HIgh-density gene-rich maps represent a powerful resource to assist gene discovery endeavors when used in combination with QTL and association mapping and should be especially valuable to assist the assembly of reference genome sequences soon to come for several plant and animal species.
Subject-Controlled, On-demand, Dorsal Genital Nerve Stimulation to Treat Urgency Urinary Incontinence; a Pilot (2016)

This feasibility study indicates that subject-controlled, on-demand DGN stimulation using a percutaneously placed electrode is possible over a longer time period, in a home setting, with a positive effect on non-neurogenic overactive bladder symptoms with UUI. Although the placement is an easy procedure, it is difficult to fixate the electrode to keep it in the correct position. Improvements in hardware, like a better fixated electrode and an easy to control stimulator, are necessary to make SODGNS a treatment possibility in the future.
Creation in Art and Science (1983)

The proposition that the creations of art are unique (in the sense tbat we would not have had Timon of Athens had Shakespeare not lived), whereas the creations of science are inevitable or commonplace (in the sense that we would have had the DNA double helix even if Watson and Crick had not lived), has little philosophical or historical merit. For, this proposition conflates works of art and science (the texts of the play Timon and of the paper A structure for Deoxyribose Nucleic Acid), both of which are unique, and their semantic content (the insights into human affects provided by Timon and the concept of the DNA double helix), both of which are commonplace as well as unique.
Reversible Deactivation of Enzymes by Redox‐Responsive Nanogel Carriers (2016)

Novel redox-responsive polymeric nanogels that allow highly efficient enzyme encapsulation and reversible modulation of enzyme activity are developed. The nanogel synthesis and encapsulation of enzyme are performed simultaneously via in situ crosslinking of pyridyldisulfide-functionalized water-soluble reactive copolymers, which are synthesized via reversible addition-fragmentation chain transfer copolymerization. Obtained nanogels with loaded cellulase demonstrate very good colloidal stability in aqueous solutions. The enzymatic activity of cellulase is greatly reduced when encapsulated in the nanogels and rapidly recovered in 10 × 10<sup>-3</sup> m dithiothreitol solution. Fluorescence resonance energy transfer (FRET)-based experiments indicate that the recovered enzymatic activity is mainly ascribed to the release of the enzyme due to the degradation of the disulfide crosslinking network after addition of dithiothreitol (DTT), instead of the enhanced substrate transport rate. The developed enzyme immobilization method opens new possibilities for reversible activation/deactivation of enzymes and opens up new directions for targeted protein therapy and biotechnology applications.
Critical Current Characteristics of YBa Cu O Thin Films on (110) SrTiO (2000)

The material and electrical characteristics of YBa Cu O (YBCO) thin films deposited by inverted cylindrical magnetron sputtering on (110) SrTiO (STO) were investigated. X-ray diffractometry shows the grain orientations to be predom- inantly the YBCO (110) and (103) with no evidence of -axis grains. Electron micrographs show the film surface to consist of coupled elongated grains parallel to the (110) STO edge. The films were patterned into small 2.5 mm squares parallel to the substrate edges for electrical characterization. Transport currents parallel and perpendicular to the (110) substrate edge showed a 945 : 1 anisotropy in film resistance and a factor of two in critical current density for temperatures below 60% of the transition temperature ( ). The temperature dependence of the critical current near was quadratic-like and strongly dependent on the value of used in the analysis. For the two orientations, there was nearly a 6K difference in as determined by the point at which the critical current became zero. The response of the critical current to small magnetic fields was greater for transport current along the -axis direction and was observable over a temperature interval nearly four times greater than for current along the basal plain. These YBCO thin films have good response to small magnetic fields and are suitable for vortex flow device development.
Preparation of Acrylonitrile-Styrene Copolymers by Calorimetrically Controlled Monomer Feeding (1975)

A fairly general solution to the problem of composition drift during batch copolymerization permits making copolymer in sufficient quantities for evaluation as a thermoplastic. By polymerizing in a calorimeter, it was possible to control monomer feed accurately in relation to rate of polymerization. The apparatus has a 2-l reaction vessel which is basically a distillation calorimeter that controls the batch temperature and measures the reaction rate and the total integrated amount of reaction, or heat, to which is aligned the monomer feed. Acrylonitrile-styrene copolymers rich in acrylonitrile were prepared by feeding styrene. The heterogeneous product formed without feeding was useless as a thermoplastic, but the homogeneous product made by feeding was very good. The mechanical properties of these copolymers improved with increasing acrylonitrile content.
Detection of St. Louis encephalitis virus in mosquitoes by use of the polymerase chain reaction. (1992)

We recently developed an assay using the polymerase chain reaction (PCR) for the specific detection of St. Louis encephalitis (SLE) virus RNA. This assay was tested in a blind study on 7 samples of pooled mosquitoes (50 mosquitoes/pool) which were also characterized for SLE virus by plaque assay in Vero cell culture. One sample was positive for the SLE virus as determined by both the PCR assay and a combination of the plaque assay and the indirect fluorescent antibody assay. The remaining 6 samples were negative for the presence of SLE virus as determined by both methods. These data indicate that this PCR assay can be used to monitor for the presence of SLE virus in pools of homogenized mosquitoes. This approach could provide early data on which to base disease control decisions.
Resonance Cone Antennas (2006)

This chapter contains sections titled: Introduction Planar Metamaterial, Corner-Fed, Anisotropic Grid Antenna Resonance Cone Refraction Effects in a Low-Profile Antenna Conclusions Acknowledgments References
Irregular Sampling of the Radon Transform of Bandlimited Functions (2013)

We provide conditions for exact reconstruction of a bandlimited function from irregular polar samples of its Radon transform. First, we prove that the Radon transform is a continuous L2-operator for certain classes of bandlimited signals. We then show that the Beurling-Malliavin condition for the radial sampling density ensures existence and uniqueness of a solution. Moreover, Jaffard's density condition is sufficient for stable reconstruction.
Promoting oral and general health behaviors in rural Kenyan schoolchildren – challenges in private versus public school settings (2015)

Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance global health, promote research, and foster the prevention and treatment of disease worldwide. Its goals are to improve the health and well-being of all people, advance health equity, and promote wise stewardship of the earth's environment. The latest journal impact factor is 2.90. Annals of Global Health is supported by the Program for Global Public Health and the Common Good at Boston College. It was founded in 1934 by the Icahn School of Medicine at Mount Sinai as the Mount Sinai Journal of Medicine. It is a partner journal of the Consortium of Universities for Global Health. From time to time, Annals of Global Health publishes Special Collections, a series of articles organized around a common theme in global health. Recent Special Collections have included "Local evidence and strategies in addressing NCDs Non-Communicable Diseases in Tanzania", "Universal Health Coverage through Integrated Care", and "The Minderoo-Monaco Commission on Plastics and Human Health". Global health workers interested in developing a Special Collection are strongly encouraged to contact the Managing Editor in advance to discuss the project.
Sleep Depth Enhancement Through Ambient Temperature Manipulation in Mice (2018)

The restorative properties of deep sleep and its central role in learning and memory are well-recognized but still in the process of being elucidated with the help of animal models. Currently available approaches for deep sleep enhancement are mainly pharmacological and may have undesirable side effects on physiology and behavior. Here, we propose a simple strategy for sleep depth enhancement that involves manipulation of ambient temperature (Ta) using a closed-loop control system. Even mild shifts in Ta are known to evoke thermoregulatory responses that alter sleep-wake dynamics. In our experiments, mice evinced greater proportions of deep NREM sleep as well as REM sleep under the dynamic sleep depth modulation protocol compared to a reference baseline in which Ta was left unchanged. The active manipulation approach taken in this study could be used as a more natural means for enhancing deep sleep in patients with disorders like epilepsy, Alzheimer's disease and Parkinson's, in which poor quality sleep is common and associated with adverse outcomes.
Mechanical strength of single microcapsules determined by a novel micromanipulation technique (1999)

A micromanipulation technique has been developed to measure the bursting force of single dry microcapsules coated onto a surface, such as those normally used in carbonless copying paper. For measuring the bursting force of a given microcapsule, a single fine probe with a flat end about 10 microns in diameter was used to squeeze the microcapsule against a flat surface until it burst. The force being imposed on the microcapsule was measured by a transducer connected to the probe. The bursting force and diameter of single dry microcapsules in two samples, different in size and wall thickness, were measured by this technique. The bursting force of the microcapsules in one sample ranged from 50 to 220 microN and the diameter from 1.3 to 7.0 microns, whilst the bursting force in the other was from 20 to 175 microN and the diameter from 0.7 to 3.7 microns. This technique makes it possible to compare the mechanical strength of microcapsules made of different formulations, and to infer information about microcapsule mechanical properties.
Differential modulation by estrogen of α2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats (2004)

We have recently shown that estrogen negatively modulates the hypotensive effect of clonidine (mixed alpha2-/I1-receptor agonist) in female rats and implicates the cardiovascular autonomic control in this interaction. The present study investigated whether this effect of estrogen involves interaction with alpha2- and/or I1-receptors. Changes evoked by a single intraperitoneal injection of rilmenidine (600 microg/kg) or alpha-methyldopa (100 mg/kg), selective I1- and alpha2-receptor agonists, respectively, in blood pressure, hemodynamic variability, and locomotor activity were assessed in radiotelemetered sham-operated and ovariectomized (Ovx) Sprague-Dawley female rats with or without 12-wk estrogen replacement. Three time domain indexes of hemodynamic variability were employed: the standard deviation of mean arterial pressure as a measure of blood pressure variability and the standard deviation of beat-to-beat intervals (SDRR) and the root mean square of successive differences in R-wave-to-R-wave intervals as measures of heart rate variability. In sham-operated rats, rilmenidine or alpha-methyldopa elicited similar hypotension that lasted at least 5 h and was associated with reductions in standard deviation of mean arterial pressure. SDRR was reduced only by alpha-methyldopa. Ovx significantly enhanced the hypotensive response to alpha-methyldopa, in contrast to no effect on rilmenidine hypotension. The enhanced alpha-methyldopa hypotension in Ovx rats was paralleled with further reduction in SDRR and a reduced locomotor activity. Estrogen replacement (17beta-estradiol subcutaneous pellet, 14.2 microg/day, 12 wk) of Ovx rats restored the hemodynamic and locomotor effects of alpha-methyldopa to sham-operated levels. These findings suggest that estrogen downregulates alpha2- but not I1-receptor-mediated hypotension and highlight a role for the cardiac autonomic control in alpha-methyldopa-estrogen interaction.