gebhart/patrepeval huggingface dataset:
Operation of solid state-power amplifiers at cryogenic temperatures (2003)

A novel approach is presented for cooling lightweight transistor amplifier modules for high-power operation. The feasibility of fabricating UHF CW (continuous wave) power amplifiers with weight-to-power output ratios of the order of 0.2 gm/W and power output approaching 2 kW (CW) is demonstrated. 1800 W (CW) at 425 MHz was obtained from a four-transistor amplifier that weighed 13 oz. Amplifier design and construction are detailed, and module performance is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The influence of hypogastric and sacral nerves on activity of the internal anal sphincteric muscle and anal canal resting pressure in the dog. (1985)

骨盤外科では,術後排便・排尿・性機能の温存のために臓器の切除範囲をできるだけ最小限に留め,骨盤内神経を可及的に温存する手段が検討されている.そこで著者らは排便機能におよぼす下腹神経および仙骨神経遮断の影響について,慢性動物実験を行い,以下の結果が得られた.1. 下腹神経切断および全仙骨神経切断術後5週まで肛門管静止圧,内括約筋筋電図活動は術前と有意差はなく,維持されていた.2. 下腹・仙骨神経切断術によっても直腸肛門反射は陽性であったが,そのパターンは正常とは異なり反射時の肛門管内圧および内括約筋筋電図活動の抑制時間は著明に延長した.3. 直腸コンプライアンスは両神経切断後1週では増大し,その後はほぼ術前値に復帰する傾向が認められた.4. 下腹・仙骨神経切断により変性再構築された壁内神経系が反射時の抑制パターンに影響を与えても肛門管静止圧には影響を与えなかった.
(Invited) Semiconductor-Based Biosensing Technology for Clinical Diagnosis (2017)

In this study, we report a biosensing method to analyze and monitor simply and easily biological phenomena such as DNA recognition events, antigen-antibody reaction and cell functions in vitro by use of a semiconductor device. As the most important point, we focus on a direct detection of ions or ionized molecules with charges, because most biological phenomena are related to ionic behaviors such as sodium or potassium ions through ion channel at cell membrane resulted from cell-cell communications, and biomolecules such as DNA molecules have intrinsic molecular charges. That is, the principle of semiconductor-based biosensing device contributes to directly detect biomolecular charges. Thus, the platform based on a semiconductor-based biosensor is suitable for a label-free and noninvasive biosensing detection device in the field of in vitro diagnosis (IVD).
Electrical properties of the slime mould grex (1970)

ABSTRACT An electrophysiological investigation of the migrating grex of the slime mould, Dictyostelium discoideum, has been carried out with two aims in view. It was hoped to obtain information which would be relevant to, first, the formation and regulation of cellular pattern in the grex, and secondly, the problem of grex movement.
Anomalous diffusion of nanoparticles in the spatially heterogeneous biofilm environment (2023)

Biofilms contain extracellular polymeric substances (EPS) that provide structural support and restrict penetration of antimicrobial treatment. To overcome limited penetration, functionalized nanoparticles (NPs) have been suggested as carriers for antimicrobial delivery. Using microscopy, we evaluate the diffusion of nanoparticles in function of the structure of Salmonella biofilms. We observe anomalous diffusion and heterogeneous mobility of NPs resulting in distinct NPs distribution that depended on biofilm structure. Through Brownian dynamics modeling with spatially varying viscosity around bacteria, we demonstrated that spatial gradients in diffusivity generate viscous sinks that trap NPs near bacteria. This model replicates the characteristic diffusion signature and vertical distribution of NPs in the biofilm. From a treatment perspective, our work indicates that both biofilm structure and the level of EPS can impact NP drug delivery, where low levels of EPS might benefit delivery by immobilizing NPs closer to bacteria and higher levels hamper delivery due to shielding effects.
Belatacept Vs. Tacrolimus: Clinical Outcomes in De Novo Kidney Transplant Recipients. (2014)

INTRODUCTION:Belatacept (CTLA-4 Ig) shows similar patient & graft survival and superior renal function compared to CSA. However, belatacept with basiliximab (IL2R) induction has a higher rate of rejection. Here we report our 12 month clinical experience with belatacept and compare outcomes with matched controls. PATIENTS AND METHODS: 39 low immunologic risk deceased donor (DD) recipients were analyzed. 13 were treated with belatacept and received allografts with anticipated DGF. 6 belatacept patients received IL2R induction & 7 received ATG. 26 retrospective controls recieved tacrolimus (tac) & matched 2 to 1. Matched characteristics included recipient age, gender, diabetes, induction, donor age, and terminal SCr. Patient & graft survival, acute rejection, cGFR, and viral complications were analyzed 12 months post-transplant. RESULTS: Outcomes in the belatacept and tac groups were not significantly different. 2 deaths occurred in the belatacept group; 1related to PCP following acute rejection and 1 related to pneumonia. Death censored graft survival was lowest in the tac/basiliximab group. Acute rejection in the belatacept group was higher (31% vs 15%), highest in the belatacept/IL2R group (50%). The belatacept/IL2R group had the highest incidence of CMV and BK viremia.Table: No Caption available.Table: No Caption available.CONCLUSION: The outcomes with belatacept were similar to tac. However, the sample size limits statistical conclusion. The belatacept/IL2R group had higher rates of rejection and viremia while the belatacept/ATG group was similar to tac treated patients. The high incidence of CMV and BK viremia in the belatacept/IL2R group was likely associated with treatments of rejection. Although not significant, 2 deaths from infection in the belatacept group are sobering and suggest intense viral monitoring would be beneficial. DISCLOSURES:Jordan, S.: Grant/Research Support, CSL-Behring, BMS, Genentech Roche.
Homogeneous Langmuir-Blodgett Film of Double-Chain Ammonium Amphiphile Complexed with Anionic Polymer (1988)

Heterogeneous textures suggesting the coexistence of a fluid and a solid phase were found both in a surface monolayer and in a deposited Langmuir-Blodgett (LB) film of double-chain ammonium amphiphiles by fluorescence microscopy. Although an annealing of the surface monolayer at 40°C allowed crystal growth, the heterogeneous phase separation remained in the LB film. A drastic change of the fluorescence image shows that the recrystallization of the complexed monolayer with anionic polymers conducted the homogeneous monolayer.
ChemInform Abstract: Synthesis and Biological Evaluation of Benzo[b]naphthyridones, a Series of New Topical Antibacterial Agents. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Bactericidal/Permeability-Increasing Protein (BPI) Is Present in Specific Granules of Human Eosinophils (1998)

Eosinophils participate in the inflammatory response seen in allergy and parasitic infestation, but a role in host defense against bacterial infection is not settled. The bactericidal/permeability-increasing protein (BPI) has been demonstrated in neutrophils and it exerts bacteriostatic and bactericidal effects against a wide variety of Gram-negative bacterial species. Using the Western blot technique, a 55-kD band, corresponding to BPI, was detected in lysates from both neutrophils and eosinophils. The localization of BPI in immature and mature eosinophils was investigated using immunoelectron microscopy. BPI was found in immature and mature specific granules of eosinophils and was detected in phagosomes as well, indicating release of the protein from the granules into the phagosomes. Using a specific enzyme-linked immunosorbent assay, eosinophils were shown to contain 179 ng of BPI/5 × 106 eosinophils compared with 710 ng BPI/5 × 106 neutrophils. The presence of BPI in eosinophils suggests a role for these cells in host defense against Gram-negative bacterial invasion or may suggest a role for BPI against parasitic infestation.
Three Antifungal Proteins From Penicillium expansum: Different Patterns of Production and Antifungal Activity (2018)

Antifungal proteins of fungal origin (AFPs) are small, secreted, cationic, and cysteine-rich proteins. Filamentous fungi encode a wide repertoire of AFPs belonging to different phylogenetic classes, which offer a great potential to develop new antifungals for the control of pathogenic fungi. The fungus <i>Penicillium expansum</i> is one of the few reported to encode three AFPs each belonging to a different phylogenetic class (A, B, and C). In this work, the production of the putative AFPs from <i>P. expansum</i> was evaluated, but only the representative of class A, PeAfpA, was identified in culture supernatants of the native fungus. The biotechnological production of PeAfpB and PeAfpC was achieved in <i>Penicillium chrysogenum</i> with the <i>P. chrysogenum</i>-based expression cassette, which had been proved to work efficiently for the production of other related AFPs in filamentous fungi. Western blot analyses confirmed that <i>P. expansum</i> only produces PeAfpA naturally, whereas PeAfpB and PeAfpC could not be detected. From the three AFPs from <i>P. expansum</i>, PeAfpA showed the highest antifungal activity against all fungi tested, including plant and human pathogens. <i>P</i>. <i>expansum</i> was also sensitive to its self-AFPs PeAfpA and PeAfpB. PeAfpB showed moderate antifungal activity against filamentous fungi, whereas no activity could be attributed to PeAfpC at the conditions tested. Importantly, none of the PeAFPs showed hemolytic activity. Finally, PeAfpA was demonstrated to efficiently protect against fungal infections caused by <i>Botrytis cinerea</i> in tomato leaves and <i>Penicillium digitatum</i> in oranges. The strong antifungal potency of PeAfpA, together with the lack of cytotoxicity, and significant <i>in vivo</i> protection against phytopathogenic fungi that cause postharvest decay and plant diseases, make PeAfpA a promising alternative compound for application in agriculture, but also in medicine or food preservation.
AMABULO - A Model Architecture for Business Logic (2008)

Models are widely used for communication and documentation purposes. They also tend to be used as parameters for code generation. Because these models have to be complete, consistent and correct we have to support modellers in keeping their models clean. The modeller should have the choice to select the preferred view and the needed level of detail for his modelling and model maintenance tasks. This paper proposes a model architecture named AMABULO for a model driven development process of business logic for information systems. The model architecture consists of a meta model, corresponding visual diagrams and an interchange format. With the use of AMABULO the development process for business logic is supported from analysis until code generation.
Cumulative Metabolic and Epigenetic Effects of Paternal and/or Maternal Supplementation with Arachidonic Acid across Three Consecutive Generations in Mice (2022)

Apart from the known associations between arachidonic acid (AA), weight gain, and neurological and immune function, AA exposure leads to alterations in global and gene-specific DNA methylation (DNAm) and fatty acid (FA) content in human cultured cells. However, it is unknown as to whether the latter effects occur in vivo and are maintained over extended periods of time and across generations. To address this issue, we asked whether AA supplementation for three consecutive generations (prior to coitus in sires or in utero in dams) affected offspring growth phenotypes, in addition to liver DNAm and FA profiles in mice. Twelve-week-old BALB/c mice were exposed daily to AA dissolved in soybean oil (vehicle, VH), or VH only, for 10 days prior to mating or during the entire pregnancy (20 days). On average, 15 mice were supplemented per generation, followed by analysis of offspring body weight and liver traits (x average = 36 and 10 per generation, respectively). Body weight cumulatively increased in F2 and F3 offspring generations and positively correlated with milligrams of paternal or maternal offspring AA exposure. A concomitant increase in liver weight was observed. Notably, akin to AA-challenged cultured cells, global DNAm and cis-7-hexadecenoic acid (16:1n-9), an anti-inflammatory FA that is dependent on stearoyl-CoA desaturase 1 (SCD1) activity, increased with milligrams of AA exposure. In accordance, liver <i>Scd1</i> promoter methylation decreased with milligrams of germline AA exposure and was negatively correlated with liver weight. Our results show that mice retain cellular memories of AA exposure across generations that could potentially be beneficial to the innate immune system.
Amplification of ultrashort pulses with a single-pass cryogenic Ti:sapphire amplifier at 80MHz repetition rate (2009)

Recently, more and more applications require amplifier systems delivering high power, short-pulsed radiation with the full repetition rate of the mode-locked oscillator. In the frequency domain, the output spectrum of the stabilized mode-locked laser consists of equidistant narrow lines separated by the laser repetition rate, often called “frequency comb”. So far, to drive highly non-linear processes directly by frequency combs requires special efforts because of the limited average output power from the mode-locked oscillator. Passive cavity amplifiers have been built to generate frequency combs in the ultra-violet region by high-order harmonics generation. For these applications, power amplifiers that can amplify short pulses from the oscillator will be an ideal tool to further improve available pulse energy at high repetition rates. In frequency comb applications, extra phase noise that is added from the amplifier has to be minimised to preserve pulse-to-pulse phase coherence. In the time domain, phase-locked amplifier system may deliver pulse trains with identical intra-pulse electric field shape. With sufficiently high pulse energy and short pulse width, it is possible to investigate carrier envelope phase dependent phenomena, such as electron emission by field ionisation and high harmonics generation. In these experiments, it is sometimes advantageous to have a high repetition rate system to obtain enough statistics for rare events in short measurement times.
Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments] (1989)

Molecular structural analysis of the p53 gene in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) indicates a significant incidence of gene rearrangements in patients at either accelerated phase or blastic crisis. Southern blot analysis of genomic DNA hybridizing with either genomic or cDNA p53 specific probes indicated that 30% of the CML patients at blastic crisis phase exhibited rearrangements, mostly mapping downstream to the first non- coding exon. This is compatible with the observation that the progression of CML from the chronic to the acute phase involves frequent aberrations in chromosome 17, to which the p53 oncogene has been mapped. Therefore, we suggest that one of the pathways of development of CML to the acute phase is associated with aberrations in the p53 nuclear oncogene.
Studies Related to the Description and Evaluation of Pistachio Nut Quality1 (1982)

Abstract The chemical composition and sensory attributes of pistachio nuts ( Pistacia vera L.) were studied in relation to genotype, production area, maturity, moisture content, degree of shell staining, and storage conditions. ‘Kerman’ kernals were rated higher in firmness and sweetness, and lower in crispness, bitterness, and rancidity than those of the ‘Red Aleppo’, ‘Trabonella’, and ‘Bronte’ cultivars. Differences in composition and flavor of ‘Kerman’ pistachios harvested from 3 production areas were small. Nuts harvested at near optimum maturity were superior in quality to those harvested earlier or later. Drying nuts to 4–6% moisture levels resulted in the best quality. Shell staining did not influence eating quality of kernels but detrimentally affected shell appearance. Dried pistachio nuts can be kept for 12 months at 20°C. Moisture content influenced crispness and firmness while total sugars content was related to sweetness and overall flavor intensity.
An Ultra-small, Low-power All-Optical Flip-Flop Memory on a Silicon Chip (2010)

A 7.5µm-diameter InP microdisk laser, integrated on an SOI waveguide is demonstrated as all-optical flip-flop working in continuous-wave regime with an electrical power consumption of several mW, and allowing switching in 60ps with pulses of 1.8fJ.
The Development of a RTD Temperature Sensor for Exhaust Applications (2004)

&lt;div class="htmlview paragraph"&gt;A RTD (resistive temperature device) high temperature sensor was developed for exhaust gas temperature measurement. Extensive modeling and optimization was used to supplement testing in development. The sensor was developed to be capable of withstanding harsh environments (-40° to 1000°C), typical of engine applications, including poisons, while maintaining high accuracy (&amp;lt; 0.5% drift after 500 hrs of aging at 950°C). The following sensor characteristics are presented: resistance-temperature curve, accuracy, response time, and long-term durability. In addition, a system error analysis program was developed with representative results.&lt;/div&gt;
Supplementary Figure 5 from Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair (2023)

&lt;p&gt;PDF file - 52K, LB100 causes an increase in pHistone H3 positive cells.&lt;/p&gt;
Myocardial perfusion reserve in adults with cyanotic congenital heart disease (2005)

In patients with cyanotic congenital heart disease (CCHD), a right-to-left shunt results in systemic hypoxemia. Systemic hypoxemia incites a compensatory erythrocytosis, which increases whole blood viscosity. We considered that these changes might adversely influence myocardial perfusion in CCHD patients. Basal and hyperemic (intravenous dipyridamole) perfusion measurements were obtained with [13N]ammonia positron emission tomographic imaging in left (LV) and right (RV) ventricular and septal myocardium in 14 adults with CCHD [age: 34.1 yr (SD 6.5)]; hematocrit: 62.2% (SD 4.8)] and 10 healthy controls [age: 34.1 yr (SD 6.5)]. In patients, basal perfusion measurements were higher in LV [0.77 (SD 0.24) vs. 0.55 ml x min(-1) x g(-1) (SD 0.09), P < 0.02], septum [0.71 (SD 0.16) vs. 0.49 ml x min(-1) x g(-1) (SD 0.09), P < 0.001], and RV [0.77 (SD 0.30) vs. 0.38 ml x min(-1) x g(-1) (SD 0.09), P < 0.001]. However, basal measurements normalized for the rate-pressure product were similar to those of controls. Calculated oxygen delivery relative to rate-pressure product was higher in the patients [2.2 (SD 0.8) vs. 1.6 (SD 0.4) x 10(-5) ml O2 x min(-1) x g tissue(-1) x (beats x mmHg)(-1) in the LV, P < 0.05, and 2.0 (SD 0.7) vs. 1.4 (SD 0.3) x 10(-5) ml O2 x min(-1) x g tissue(-1) x (beats x mmHg)(-1) in the septum, P < 0.01]. Hyperemic perfusion measurements in CCHD patients did not differ from controls [LV, 1.67 (SD 0.60) vs. 1.95 ml x min(-1) x g(-1) (SD 0.46); septum, 1.44 (SD 0.56) vs. 1.98 ml x min(-1) x g(-1) (SD 0.69); RV, 1.56 (SD 0.56) vs. 1.65 ml x min(-1) x g(-1) (SD 0.64), P = not significant], and coronary vascular resistances were comparable [LV, 55 (SD 25) vs. 48 mmHg x ml(-1) x g x min (SD 16); septum, 67 (SD 35) vs. 50 mmHg x ml(-1) x g x min (SD 21); RV, 59 (SD 26) vs. 61 mmHg x ml(-1) x g x min (SD 27), P = not significant]. These findings suggest that adult CCHD patients have remodeling of the coronary circulation to compensate for the rheologic changes attending chronic hypoxemia.
Preparing Frozen Bacterial Stocks (1997)

After bacteria containing plasmids of interest have been produced, it is frequently convenient to store them for later use. This appendix provides instruction for storing bacteria in such a way that they typically remain viable for years.
Fast and precise discriminant function considering correlations of elements of feature vectors and its application to character recognition (1999)

During the last few years, research in recognition of handwritten Chinese and Japanese characters has matured significantly. However, in order to obtain high recognition rate, most character recognition systems have paid an extremely high computational cost. For high-performance character recognition systems, reduction of the expensive computational cost has become a very important goal. Discriminant function is a very important factor for precise pattern recognition. The Mahalanobis distance is considered as an effective function. However, precise calculation of the Mahalanobis distance requires extremely large numbers of training samples. In this article, by investigating the relationwhip of elements of feature vector, a new discriminant function, the vector-partitioned Mahalanobis distance, is proposed. With the proposed method, high recognition performance can be obtained with less computational cost. Because the proposed method partitions high dimensional feature vector into several small number dimensional vectors, the ratio of the number of training samples to the number of dimensions becomes larger. This method is especially effective in the case of lack of training samples. The effectiveness of the proposed method is shown by experimental results with the database ETL9B. © 1999 Scripta Technica, Syst Comp Jpn, 30(14): 33-42, 1999
Enhancement of Morphological and Optoelectronic Properties of Perovskite Films by CH3NH3Cl Treatment for Efficient Solar Minimodules (2018)

In order to get homogeneous and high-quality perovskite CH3NH3PbI3 films, different growing methods have been developed, but most of them are unsuitable for scaling up. In this work, we studied in a systematic approach the influence of CH3NH3Cl (MACl) surface treatment in the acetonitrile (ACN) deposition route. This method does not require vacuum nor solvent quenching steps, which make it probably one of the easiest for transference from lab scale to large-area deposition techniques such as roll-to-roll printing. The properties of perovskite films grown by ACN method and the influence of the MACl on the performance of the perovskite solar cells (PSCs) are characterized in detail by different techniques. By atomic force microscopy (AFM) and Kelvin probe force microscopy (KPFM) we found significant differences in the morphology and the work function of the perovskite with and without MACl treatment. Moreover, the microstructure presents very different behavior: after being exposed to radiation, the MACl treated sample presented passivated grain boundaries and higher intensity in the photoluminescence (PL) emission. The higher PL for perovskite films with MACl treatment correlates with superior photovoltaic parameters of PSCs. All these features lead to highly homogeneous perovskite layers on large areas enabling the fabrication of 10 × 10 cm2 solar minimodules processed in air at low temperature (<100 °C). For these minimodules, we reached a PCE up to 9.2% with an aperture area of 40 cm2. These results demonstrate the potential of perovskite surface treatments as an effective strategy for the production of smooth, pinhole free films on large-area substrates, the gateway for further scale-up and commercialization.
Pneumopericardium and pneumothorax contralateral to venous access site after permanent pacemaker implantation (2003)

A 77-year-old female underwent implantation of a left-sided dual chamber permanent pacemaker for symptomatic bradycardia with active fixation leads. Eight hours after the procedure, the patient complained of shortness of breath and was found to have a 30% right pneumothorax on chest X-ray. Immediately, a chest tube was inserted, promptly relieving the symptoms. A CT scan of the chest revealed extrusion of the helix of the screw-in atrial lead, through the wall of the right atrial appendage. The helix was abutting a bulla in the right lung, the likely cause for pneumothorax and pneumopericardium. The atrial lead was explanted without incident.