gebhart/patrepeval huggingface dataset:
Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G0/G1 in HPV18+ human cervical cancer HeLa cell line (2017)

Cervical cancer is the fourth most common cancer among women worldwide and is a major cause of morbidity and mortality. High-risk Human Papilloma Virus (mostly type 16 & 18) infection is the primary risk factor for the development of cervical carcinoma. The quest for strong, safe and cost effective natural antiproliferative agents that could reduce cervical cancer have been focussed now a day. Recently, glycyrrhizin, a triterpene glycoside (saponin) from licorice (Glycyrrhiza glabra Linn.), has been shown to exhibit potent antiproliferative and anticancer properties in a few preliminary studies. However, potential of this compound in cervical cancer has not been elucidated yet. Therefore the objective of this study was to analyze the antiproliferative and apoptotic properties of glycyrrhizin in human cervical cancer HeLa cells. Our results showed that glycyrrhizin exposure significantly reduced the cell viability of HeLa cells with a concomitant increase in nuclear condensation and DNA fragmentation in a dose dependent manner. The intracellular ROS generation assay showed dose-related increment in ROS production induced by glycyrrhizin. Glycyrrhizin also induced apoptosis in cervical cancer cells by exerting mitochondrial depolarization. Cell cycle study showed that glycyrrhizin induced cell cycle arrest in G<sub>0</sub>/G1 phase of cell cycle in a dose dependent manner. Thus, this study confirms the efficacy of glycyrrhizin in cervical cancer cells which could be an adjunct in the better prevention and management of cervical cancer worldwide.
A New Security Testing Method and its Application to the Secure Xenix Kernel (1986)

A new security testing method is proposed that combines the advantages of both traditional "black box" (monolithic functional) testing and "white box" (functional-synthesis- based) testing. The new method allows significant coverage both for security model-based tests and for individual kernel-call tests. It eliminates redundant kernel test cases (1) by using a variant of control synthesis graphs, (2) by analyzing dependencies between descriptive kernel-call specifications, and (3) by exploiting access check separability. A higher degree of test assurance is achieved than that of other security testing methods because the new method helps eliminate cyclic dependencies among test programs for different kernel calls. The application of this method to the testing of the Secure Xenix* kernel is illustrated. The design and the implementation of Secure Xenix are presented in a companion paper.
Home blood pressure telemonitoring improves hypertension control in general practice. The TeleBPCare study (2008)

Patients' management based on home blood pressure teletransmission led to a better control of ambulatory blood pressure than with usual care, with a more regular treatment regimen.
Dynamic Synchrophasor Estimation by Extended Kalman Filter (2019)

Fast synchronized measurements of the phasor, frequency, and rate of change of frequency are expected to be very important for the automated control actions in the smart grid context. In this regard, measurement latency must be kept as short as possible for an effective control implementation when networks characterized by extremely fast dynamics are concerned. Kalman filter (KF)-based estimation algorithms appear to be attractive in this context; however, the conventional implementations suffer from significant limitations in their ability to deal with different types of dynamic conditions due to approximations in the model and in the associated uncertainty. This article proposes an innovative solution, based on an extended KF algorithm using a Taylor model, which is shown to provide improved tracking ability in a vast range of dynamic conditions. A novel element in the proposed technique is the representation of model uncertainty, which takes into account the intrinsic correlation among errors that appear in the state-space description under dynamic conditions. A compatibility check between the forecast and measurement result is also introduced as an effective and metrologically sound approach to detect large unexpected changes in the tracked parameters in order to achieve a fast response of the algorithm also under those conditions. The performance of the algorithm is thoroughly investigated by means of simulation to demonstrate the significant improvement compared to other KF solutions in some conditions of practical relevance.
Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice (2014)

Siglec-G is a member of the sialic acid-binding Ig-like lectin (Siglec) family expressed on all B cells. Siglec-G-deficient mice show a large expansion of the B1 cell compartment, demonstrating the crucial role of Siglec-G as an inhibitory receptor on this cellular subset. Although Siglec-G-deficient mice did not develop spontaneous autoimmunity, mice double-deficient for Siglec-G and the related Siglec protein CD22 did show autoimmunity at an older age. In this study, we addressed the question of whether loss of Siglec G on its own affects disease severity in animal models of rheumatoid arthritis and systemic lupus erythematosus. Siglec-G-deficient mice showed moderately increased clinical severity and higher inflammation of the knee joints following collagen-induced arthritis, when compared with control mice. The Siglec-G-deficient mouse was also backcrossed to the autoimmune prone MLR/lpr background. Although both Siglec-G-deficient and control MRL/lpr mice developed a lupus-like disease, Siglec-G-deficient MRL/lpr mice showed an earlier occurrence of autoantibodies; a higher lymphoproliferation of B and T cells; and an earlier onset of disease, as shown by proteinuria and glomerular damage in the kidney. Moreover, Siglec-G-deficient female mice showed a significantly reduced survival compared with female control MRL/lpr mice. Thus, the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr mice.
The Pseudomonas oleovorans alkane hydroxylase gene (1989)

We have identified and sequenced the Pseudomonas OCT plasmid-encoded alkane hydroxylase gene (alkB) and its promoter. The transcription initiation site of the alkBAC mRNA was determined by nuclease S1 mapping. A putative interaction site with RNA-polymerase was identified based on homology of the alk promoter with other Pseudomonas promoters. The alkB gene encodes a 401-amino acid polypeptide which, despite an unusual codon composition, can be expressed at high levels in Escherichia coli and Pseudomonas. The amino-terminal sequence of the purified cytoplasmic membrane alkane hydroxylase was determined and was found to be in agreement with the nucleotide sequence. The translation product of the alkB gene contains nine hydrophobic sequences of which eight are sufficiently long to be membrane-spanning segments. The amino-terminal sequence resembles that of several bacterial integral membrane proteins and is not cleaved off following translation.
Passive aerostability for drag sails (2013)

Drag sails deorbiting devices are an interesting option to deorbit defunct spacecraft. They are passive devices that can be accommodated as an independent system to the spacecraft thus causing nearly no impact and enabling them to be deployed after the true end-of-life is reached. Although presenting some key competitive advantages against traditional deorbiting systems (like direct deorbit burns), they also have some disadvantages. One of these disadvantages is that the drag created is a function of the cross-section area with respect to the flow and hence, it is a function of the spacecraft attitude. As the drag sail is deployed at the end-of-life, the spacecraft will not have any means to actively control the attitude and analysis shows that the system will end up tumbling. This tumbling causes a reduction on the effective cross-sectional area which has a negative impact on the drag sail performance. To mitigate this effect the drag sail can be designed to be passively aerostable. In this case, the spacecraft maintains constant relative attitude with respect to the flow, hence maximizing the effective cross-section area and therefore improving the drag sail performance. In an aerostable drag sail the sail provides an aerodynamic restoring torque when the attitude is not the desired one. Unfortunately this torque is conservative and if damping is not added the spacecraft would oscillate around the equilibrium point. This damping system could be mechanical (using a viscous damper) and could be activated at drag sail deployment (so it is not active during the spacecraft active life). This paper is a requirements analysis for such a damping system and its objective is to help future research and implementation of passive damping systems. To do this, the performance advantages of aerostable drag sails are examined then, the different design parameters (aerodynamic stiffness and damping ratio) and their sensitivities are studied and, finally, several sail geometries are proposed and analysed. Copyright
Atom transfer between precision nanoclusters and polydispersed nanoparticles: a facile route for monodisperse alloy nanoparticles and their superstructures (2020)

Reactions between atomically precise noble metal nanoclusters (NCs) have been studied widely in the recent past, but such processes between NCs and plasmonic nanoparticles (NPs) have not been explored earlier. For the first time, we demonstrate spontaneous reactions between an atomically precise NC, Au25(PET)18 (PET = 2-phenylethanethiol), and polydispersed silver NPs with an average diameter of 4 nm and protected with PET, resulting in alloy NPs under ambient conditions. These reactions were specific to the nature of the protecting ligands as no reaction was observed between the Au25(SBB)18 NC (SBB = 4-(tert-butyl)benzyl mercaptan) and the very same silver NPs. The mechanism involves an interparticle exchange of the metal and ligand species where the metal-ligand interface plays a vital role in controlling the reaction. The reaction proceeds through transient Au25-xAgx(PET)n alloy cluster intermediates as observed in time-dependent electrospray ionization mass spectrometry (ESI MS). High-resolution transmission electron microscopy (HRTEM) analysis of the resulting dispersion showed the transformation of polydispersed silver NPs into highly monodisperse gold-silver alloy NPs which assembled to form 2-dimensional superlattices. Using NPs of other average sizes (3 and 8 nm), we demonstrated that size plays an important role in the reactivity as observed in ESI MS and HRTEM.
Toward Remote Service Invocation in Android (2012)

Android has spread as a platform for not only smart phones and tablet devices but also embedded devices. When Android was adapted for embedded systems, various kinds of application software were considered. One of these applications is to build collaborative and cooperative work environments. In developing software for collaborative and cooperative work, transparent invocation of remote services in other devices is expected. In this paper, we evaluate whether the inter-process communication mechanism in Android can be used in remote service invocation using the application layer protocol in the feasibility study. Moreover, we propose intent class extension to realize transparent remote service communication to other devices without any modifications to the Android application.
A Multifaceted Approach to Particle Analysis (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009
Correction: Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis (2021)

[This corrects the article DOI: 10.1039/C9SC00302A.].
Meta4P: A User-Friendly Tool to Parse Label-Free Quantitative Metaproteomic Data and Taxonomic/Functional Annotations (2023)

We present Meta4P (MetaProteins-Peptides-PSMs Parser), an easy-to-use bioinformatic application designed to integrate label-free quantitative metaproteomic data with taxonomic and functional annotations. Meta4P can retrieve, filter, and process identification and quantification data from three levels of inputs (proteins, peptides, PSMs) in different file formats. Abundance data can be combined with taxonomic and functional information and aggregated at different and customizable levels, including taxon-specific functions and pathways. Meta4P output tables, available in various formats, are ready to be used as inputs for downstream statistical analyses. This user-friendly tool is expected to provide a useful contribution to the field of metaproteomic data analysis, helping make it more manageable and straightforward.
On the Controlled Loading of Single Platinum Atoms as a Co‐Catalyst on TiO2 Anatase for Optimized Photocatalytic H2 Generation (2020)

Single-atom (SA) catalysis is a novel frontline in the catalysis field due to the often drastically enhanced specific activity and selectivity of many catalytic reactions. Here, an atomic-scale defect engineering approach to form and control traps for platinum SA sites as co-catalyst for photocatalytic H<sub>2</sub> generation is described. Thin sputtered TiO<sub>2</sub> layers are used as a model photocatalyst, and compared to the more frequently used (001) anatase sheets. To form stable SA platinum, the TiO<sub>2</sub> layers are reduced in Ar/H<sub>2</sub> under different conditions (leading to different but defined Ti<sup>3+</sup> -O<sub>v</sub> surface defects), followed by immersion in a dilute hexachloroplatinic acid solution. HAADF-STEM results show that only on the thin-film substrate can the density of SA sites be successfully controlled by the degree of reduction by annealing. An optimized SA-Pt decoration can enhance the normalized photocatalytic activity of a TiO<sub>2</sub> sputtered sample by 150 times in comparison to a conventional platinum-nanoparticle-decorated TiO<sub>2</sub> surface. HAADF-STEM, XPS, and EPR investigation jointly confirm the atomic nature of the decorated Pt on TiO<sub>2</sub> . Importantly, the density of the relevant surface exposed defect centers-thus the density of Pt-SA sites, which play the key role in photocatalytic activity-can be precisely optimized.
High-Resolution Electron Microscopy Study of Enamel Crystal Growth in Human Foetus (1990)

The mineral component of human dental enamel is formed by nonstoichiometric carbonated hydroxyapatite crystals. The presence of relatively large amounts of impurities in mature enamel crystals as well as their external shape are related to their growing mechanism. Enamel crystal growth was investigated previously directly with low resolution electron microscopy or by comparison with synthetic apatite crystal growth. The growing process of enamel crystals is still unknown and the aim of this study was to investigate foetal enamel growth during secretory stage by high resolution transmission electron microscopy. Developing enamel from 5 month-old human foetuses was fixed for 3 hours in a 2% glutaraldehyde and 2% paraformaldehyde solution in 0.1 M sodium cacodylate buffer. After 2 hour postfixation in 1% O s O 4 in the same buffer and embedding in Epon, non decalcified ultrathin sections were obtained with a Sorvall-Porter MT-2C microtome equipped with a diamond knife and floated on demineralized water saturated against hydroxyapatite (200mg/l). The sections were observed in a Philips EM 430 transmission electron microscope operating at 300 kV equipped with a double tilt specimen holder. This microscope possessed a Sherzer resolution of 0.19 nm and the absence of drift and astigmatism was checked for each micrograph by an optical diffraction.
Switch-to-Semaglutide Study (STS-Study): a Retrospective Cohort Study (2021)

Switching to semaglutide from established GLP-1 analogue therapy improved HbA1c and body weight. Both equipotential and stepwise dosing initiation appear to be effective and well tolerated.
Laser Spinning: A New Technique for Nanofiber Production (2014)

Laser Spinning is a new technique to produce ultralongnanofibers with tailored chemical compositions. In this method, a high power laser is employed to melt a small volume of the precursor material at high temperatures. At the same time, a supersonic gas jet is injected on this molten volume producing its rapid cooling and elongation by viscous friction with the high speed gas flow, hence forming the amorphous nanofibers. This paper collects the main results obtained since the introduction of this technique in 2007.
Osseointegrated Oral Implants (1988)

Fourteen Swedish teams outside the University of Gothenburg, each with minimally three years' experience in the Nobelpharma osseointegrated implant participated in a retrospective multiclinic study. The total number of consecutively inserted implants at the 14 clinics was 8139. The outcome of every implant was reported and all implant failures, irrespective of when they occurred, were published. The success criteria included absence of implant mobility, absence of radiolucent zones on x-rays, and an annual bone loss after the first year of less than 0.2 mm. In the mandible 334 implants were followed for five to eight years, with only three failures, for a success rate of 99.1%. In the maxilla 106 implants were followed for five to seven years, with a success rate of 84.9%. In irradiated and grafted mandibles, 56 implants were inserted and none was lost during a follow-up of up to five years. In the irradiated maxilla there were 16 implants inserted with three reported failures and in the grafted upper jaw 71 implants were inserted with 12 failures. The proportions of mandibular and maxillary sleeping implants were 0.8 and 0.3%, of patient drop-out implants 0.3 and 0.6%, and of patient death implants 0.9 and 1.2%, respectively. It was concluded that the osseointegrated implant, if inserted according to the guidelines of Brånemark, results in a very high degree of clinical success, thereby meeting any published oral implant success criteria.
Gradient Based Optimization of the WAG Process with Smart Wells (2004)

B032 GRADIENT BASED OPTIMIZATION OF THE WAG PROCESS WITH SMART WELLS ABSTRACT 1 Smart well technology (“downhole measurement and control”) has progressed significantly over the last few years. Previous research has concentrated on the application of the technology to primary and secondary recovery 1 2 . This study aims to advance the technical application to tertiary recovery concentrating on water-alternating-gas (WAG) processes. The primary operational problem cited in literature is early breakthrough in production wells 3 . This is then potentially a prime candidate for smart wells based on the initial success with smart wells in mitigating early breakthrough and
Electric and Magnetic Properties of Thermal Spray Coatings with an Amorphous Structure (1998)

Abstract Physical properties of coatings based on Fe-B, Fe-Ni-B, Fe-Cr-P-C, Fe-Ni-Si-B, Ni-P, Ni-Nb and Co-Fe-B-Si, deposited by the methods of flame, plasma-arc, and detonation spraying were investigated. The coatings have mostly the amorphous structure with the volume content of the amorphous phase equal to 75-95 %. Values of the distribution and temperature coefficients of electric resistance of the coatings, depending upon a method and conditions of spraying, as well as upon their treatment parameters, were determined. Comparative studies of these coatings and thin amorphous strips produced by the melt spinning method were conducted. The amorphous coatings of ferromagnetic iron and cobalt alloys are shown to be magnetically soft materials and are characterized by a high magnetic induction combined with a high magnetic permeability. As compared with the amorphous strips, Curie temperature of the amorphous ferromagnetic coatings is by 50-140 K higher and their anisotropy of magnetic properties is lower.
Historical perspective on R. Bruce Lindsay, A. O. Williams, R. T. Beyer, and P. J. Westervelt: Connections and branches surrounding the Brown era (2013)

Starting from a timeline when R(obert) Bruce Lindsay graduated from Brown (1920), there is a lineage of so-called great-grandfather, grandfather, and father advisors leading up to his own research, and branches connecting new Ph.D.’s. His Ph.D. on the atomic models of the alkali metals began in Copenhagen, Denmark, under Niels Bohr and H.A. Kramers in 1922, and was completed at M.I.T. in 1924. Bruce Lindsay returned to Brown University in 1930 (from Yale), became chair in 1934 and Hazard professor in 1936. His interests in atomic physics switched to acoustics during and after WWII, obtained strong support from ONR and kindled a legendary relationship with the ASA, including 20 years as Editor-in Chief, and a gold medal. He brought on board Art Williams (1940), Robert Beyer (1945), and Peter Westervelt (1951). They also received medals. R.T. Beyer’s advisor at Cornell, Harry Sack, was a former student of Peter Debye. A.O. William’s and P. J. Westervelt’s advisors were Bruce Lindsay and Richard Bolt (M.I.T.), respectively. This poster presentation will also include threading together acoustics at Brown in an era including Jordan Markham, Bob Morse, Rohn Truell, Bruce Chick, Wes Nyborg, Charles Elbaum, and Humphrey Maris.
Studies on Uricosuric Diuretics. V. Convenient and Efficient Synthesis of 2,3-Dihydrobenzofuran Derivatives. (1992)

A practical procedure for synthesis of a new uricosuric agent, 5-chloro-7, 8-dihydro-3-phenylfuro[2, 3-g]-1, 2-benzisoxazole-7-carboxylic acid (1, AA-193) is described, which starts from 2, 5-dichlorophenol (3b) and involves 5-chloro-6-hydroxy-3-phenyl-1, 2-benzisoxazole (2) as the key intermediate. Successive treatment of 3b with benzoyl chloride-aluminum chloride (AlCl3) and hot ethanolic sodium hydroxide gives 4-benzoyl-2, 5-dichlorophenol (8, 61%), which is oximated with hydroxylamine hydrochloride and then transformed into the benzisoxazole 2 (88%) with potassium hydroxide in N, N-dimethylformamide (DMF) (method C). The reaction of 2 with aqueous formaldehyde and dimethylamine affords the Mannich base 11a (97%), which is treated with a sulfonium ylide 12, 14 or 15 followed by heating with sodium hydroxide (NaOH) in ethanol (EtOH) to give 1 in high yield (method E).
Evaluating VIIRS ocean color products for west coast and Hawaiian waters (2013)

Automated match ups allow us to maintain and improve the ocean color products of current satellite instruments MODIS, and since February 2012 the Visible Infrared Imaging Radiometer Suite (VIIRS). As part of the VIIRS mission Ocean Calibration and Validation Team, we have created a web-based automated match up tool that provides access to searchable fields for date, site, and products, and creates matchups between satellites (MODIS, VIIRS), and in-situ measurements (HyperPRO and SeaPRISM). The goal is to evaluate the standard VIIRS ocean color products produced by the IDPS and available through NOAA’s CLASS data system. Comparisons are made with MODIS data for the same location, and VIIRS data processed using the NRL Automated Processing System (APS) used to produce operational products for the Navy. Results are shown for the first year of VIIRS data matching the satellite data with the data from Platform Eureka SeaPRISM off L. A. Harbor in the Southern California Bight, and HyperPRO data from Station ALOHA near Hawaii.