gebhart/patrepeval huggingface dataset:
Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis (1988)

Concentrations of erythromycin and 2'-acetyl erythromycin were analysed in serum or plasma and tonsil tissue after repeated dosage of erythromycin acistrate (EA), a new erythromycin prodrug, in two separate studies in 61 young patients. The reference preparations were: (1) enterocoated tablets of erythromycin base (EB enterotablets, (2) erythromycin base as enterocoated pellets (EB enterocapsules) and (3) erythromycin stearate (ES). All drugs were given 500 mg tid for three days before scheduled tonsillectomy. Tonsils were removed about 3 h after intake of the last dose. Blood samples were collected at 0, 2 and 6 h and at the time of tonsillectomy. At all time points EA produced several-fold higher total drug (erythromycin + 2'-acetyl erythromycin) concentrations in serum or plasma than any of the reference preparations. Similarly, after EA the mean total antibiotic levels in tonsil tissue exceeded the erythromycin levels after the reference preparations by at least a factor of 3. Tonsil/serum or plasma ratios of the total antibiotic were quite similar with all preparations (means 38-50%). Peak erythromycin levels in circulation did not differ significantly from each other in spite of two nonabsorbers after EB enterotablets. The same was true of tonsil tissue. There were, however, 15 tonsils with undetectable erythromycin: 4/25 (16%) with EA, 5/12 (42%) with EB enterotablets, 2/12 (17%) with EB enterocapsules and 4/12 (33%) with ES. The degree of hydrolysis of 2'-acetyl erythromycin to erythromycin was 23-43% higher in tonsil tissue than in circulation.
Enhanced Carrier Lifetime in Bulk-Grown 4H-SiC Substrates (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
집단상담 수업 경험에 대한 학습자의 인식: 내용, 방법, 성과를 중심으로 (2017)

이 연구는 대학원 학위 과정에 개설된 집단상담 수업에 참여한 대학원생들을 대
상으로 학습자들이 인식하는 긍정적인 수업의 내용 요소와 방법 요소, 그리고 성과
에 대한 내용을 살펴보는 것을 목적으로 한다. 이를 위해 전국 10여개 대학의 대학
원에 재학 중인 상담 및 상담 관련 전공 대학원생을 대상으로 2016년 6월∼9월의
기간 동안 온라인 설문조사를 실시하였다. 자료 분석은 CQR-M의 방법으로 실시하
였으며 2016년 10월∼2017년 1월에 걸쳐 최종적으로 106명의 자료가 분석되었다.
주요 연구 결과는 다음과 같다. 첫째, 집단상담 수업의 내용 요소 중 학습자들이 긍
정적으로 인식하는 내용은 집단상담 관련 지식, 집단 운영 기술, 집단상담자 자질
및 윤리의 3가지 범주로 나타났다. 둘째, 집단상담 수업의 형식 요소 중 학습자들이
긍정적으로 인식하는 수업 방법은 집단상담 이론 학습방법, 간접실습방법, 직접실습
방법, 그리고 수퍼비전의 4가지 범주로 나타났다. 셋째, 학습자들이 인식하는 수업
의 성과는 개인내적변화, 집단에 대한 신뢰 형성 및 심화, 전문성 함양이라는 3가지
범주로 나타났다. 이와 같은 연구결과는 교육의 수요자가 되는 학습자들의 인식을
통해 상담자 교육과정에 반영할 수 있는 구체적인 시사점을 제공하였다는 의의를
지닌다.
Molecular-level assemblies on metal oxide surfaces (1996)

This is the final report of a one-year, Laboratory-Directed Research and Development project at the Los Alamos National Laboratory (LANL). The objective of this project was to explore molecular-level assemblies based on polypyridyl transition metal complexes attached to metal oxide surfaces to provide the basis for applications such as energy conversion and electricity generation, photoremediation of hazardous waste, chemical sensors, and optical storage and photorefractive devices for communications and optical computing. We have elucidated the fundamental factors that determine the photochemistry and photophysics of a series of these photoactive inorganic complexes in solution and on metal oxide substrates by exploiting our unique transient laser capabilities. This data is being utilized to design and fabricate molecular-level photonic devices. The rich chemistry of transition metal polypyridyl complexes can be utilized to prepare molecular assemblies having well-defined redox or excited-state properties that can be finely tuned to produce desired materials properties. We plan to explore other novel applications such as photorefractive switches and optical sensors using this molecular engineering approach.
Determining Optimal Cardiac Preload during Resuscitation Using Measurements of Ventricular Compliance (2001)

In critically injured patients, bedside assessment of right ventricular compliance is possible and may help determine optimal values of RVEDVI during resuscitation.
Interaction of Candida albicans with human gut epithelium in the presence of Live Biotherapeutic Products (LBPs) (2021)

Candida albicans is a semi-ubiquitous pathobiont that is known to significantly impact human health and wellbeing, causing a significant financial strain on the medical system. Due to increasing antifungal resistance, there is a growing need for novel fungal therapeutics to treat diseases caused by this fungus. The development and use of Live Biotherapeutic Products (LBPs) is an innovative and novel approach to potentially treating Candidiasis and other comorbidities associated with C. albicans infection. To evaluate their anti-pathogenic efficacy, it is necessary to understand the underlying mechanisms involved, via the use of biomimetic cell models. In this study, six LBPs were chosen to investigate their competitive inhibitory effect against C. albicans using a co-culture of Caco-2 cells and mucous-secreting HT29-MTX cells to mimic human gut epithelium. The LBP strains were supplied by Servatus Biopharmaceuticals and identified as SVT 01D1, SVT 04P1, SVT 05P2, SVT 06B1, SVT 07R1 and SVT 08Z1. Five out of the six LBPs showed a significant reduction in the adhesion of C. albicans and all six LBPs reduced C. albicans invasion in the co-culture cells to varying degrees. There was no significant difference between co-inoculation of C. albicans with the LBPs or pre-inoculation of LBPs before the addition of C. albicans. The potential of these LBPs as novel anti-fungal therapeutics for the treatment of C. albicans diseases can be further documented in clinical trials.
Numerical simulation of electromagnetic field and experimental validation of resonant inductive wireless power transfer system to feed load (2017)

This paper presents the design and the results of a resonant inductive wireless power transfer system that supplies a load situated at 15cm from the source. This system contains two circuits: one transmitter and other receiver. According to references [1]-[5], resonant inductive coupling is classified as the most effective for these type of applications. Initially the system is powered with 12V DC. Experimental results validate the resonant inductive wireless power transfer system. The numerical simulations of the electromagnetic field for wireless power transfer are also have presented in this work.
Gas analysis using an infrared source with temporally varying temperature (2001)

A novel technique of analysing mixtures of infrared active gases without the need of narrow-band wavelength filters uses the dependence of the absorption on the temperature of a black body source. By pulsing the voltage on a filament light source, the temperature-dependent absorption spectrum is displayed as a function of time. Individual and simultaneous monitoring of carbon dioxide and water vapour in the atmosphere is demonstrated. The performance is considerably enhanced by using a sequence of pulses of different lengths.
Validation of Computer Assisted Percutaneous Microwave Ablation of Liver Tumours – Feasibility and Safety Assessment (2014)

Introduction For patients with liver tumours not treatable with open liver surgery due to comorbidities or where the tumour is not visible with ultrasound or in the situation with vanished lesions, an alternative could be CT-guided microwave ablation with computer assisted navigation (CAS-one, Cascination AG, Bern, Switzerland). Compared to standard CT-guidance, the addition of CAS-one could improve accuracy, reduce radiation dose and anaesthesia time.
Probing short-range order in γ-Fe2O3 as a function of Ce addition (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma (2014)

In the AR/C subjects with reported well-controlled mild asthma included in these studies, grass SLIT-tablet did not increase TEAE frequency, severe local allergic swelling, or systemic allergic reactions versus subjects without asthma. There was no indication that treatment led to acute asthma worsening.
Studies on the Constituents of Corydalis sps. IV. : Studies on the Quaternary Base of Korean Corydalis (1968)

The quaternary base fraction of Korean Corydalis was examined. The alkaloids isolated from this fraction by means of alumina column chromatography were berberine nitrate, berberine chloride, coptisine nitrate, and noroxyhydrastinine. On the other hand, reduction of the quaternary base fraction to tertiary bases with sodium borohydride afferded dl-canadine, dl-tetrahydrocoptisine, and dl-tetrahydrocorysamine. From this finding, the presence of corysamine in situ was suggested.
Plasmatron Reformation of Renewable Fuels (2005)

The characteristics of plasmatron reformers for the generation of hydrogen rich gas using renewable fuels is discussed. Biodiesel and ethanol have been investigated. Operating as a function of the air/fuel ratio is evaluated, as well as the impact of the plasma. I.
High affinity ligand binding is not essential for granulocyte-macrophage colony-stimulating factor receptor activation. (1992)

The high affinity receptor of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is a heterodimer composed of two members of the cytokine receptor superfamily. GM-CSF binds to the alpha-subunit (GM-R alpha) with low affinity and to the receptor alpha beta complex (GM-R alpha beta) with high affinity. The GM-CSF.GM-R alpha beta complex is responsible for biological activity. Interactions of the N-terminal helix of mouse GM-CSF with mGM-R alpha beta were examined by introducing single alanine substitutions of hydrophilic residues in this region of mGM-CSF. The consequences of these substitutions were evaluated by receptor binding and biological assays. Although all mutant proteins exhibited near wild-type biological activity, most were defective in high affinity receptor binding. In particular, substitution of Glu-21 with alanine abrogated high affinity binding leaving low affinity binding unaffected. Despite near wild-type biological activity, no detectable binding interaction of this mutant with mGM-R beta in the context of mGM-R alpha beta was observed. Cross-linking studies showed an apparent interaction of this mutant protein with mGM-R alpha beta. The deficient receptor binding characteristics and near wild-type biological activity of this mutant protein demonstrate that mGM-CSF receptor activation can occur independently of high affinity binding, suggesting that conformational changes in the receptor induced by mGM-CSF binding generate an active ligand-receptor complex.
Exploiting current understanding of antibiotic action for discovery of new drugs (2002)

The introduction of antibiotics for the chemotherapy of bacterial infections has been one of the most important medical achievements of the past 50 years. However, the emergence of bacterial resistance to antibiotics undermines the therapeutic utility of existing agents, creating a requirement for the discovery of new antibacterial drugs. Several drug discovery strategies have emerged, including incremental improvements to existing antibiotics by chemical manipulation and the search for novel drug targets based on genomic approaches. An alternative strategy seeks to exploit opportunities for drug discovery arising from an understanding of the mode of action of existing antibiotics. Thus biochemical pathways or processes inhibited by antibiotics already in clinical use may nevertheless contain key functions that represent unexploited targets for further drug discovery. A major benefit of employing pathways or processes that are already known to contain drug targets is that proof of principle for drug intervention is already established. This approach to drug discovery is illustrated by reviewing target sites for existing antibiotics and considering how this information might be applied for the discovery of new agents inhibiting peptidoglycan synthesis, tRNA synthesis, transcription and DNA replication
Multiplexed localized surface plasmon resonance sensing with suspended core fibers (2012)

Sensors based on the localized surface plasmon resonance (LSPR) effect are known as sensitive methods for refractive index measurements or for detection of specific binding reactions in biosensing due to a variation in layer thickness. Fiber based arrangements are able to perform such measurements with very small analyte volumina. A generalization of this concept for a multiplexed measurement of different biomolecules in a single fiber could be an attractive approach. We discuss the possibility of selectively sensitizing the inner surfaces of a suspended core fiber with two different metallic nanoparticle types in monolayers for such multiplexed measurements.
Genomic Selection Accuracy for Grain Quality Traits in Biparental Wheat Populations (2011)

ABSTRACT Genomic selection (GS) is a promising tool for plant and animal breeding that uses genome‐wide molecular marker data to capture small and large effect quantitative trait loci and predict the genetic value of selection candidates. Genomic selection has been shown previously to have higher prediction accuracies than conventional marker‐assisted selection (MAS) for quantitative traits. In this study, we compared phenotypic and marker‐based prediction accuracy of genetic value for nine different grain quality traits within two biparental soft winter wheat ( Triticum aestivum L.) populations. We used a cross‐validation approach that trained and validated prediction accuracy across years to evaluate effects of model training population size, training population replication, and marker density. Results showed that prediction accuracy was significantly greater using GS versus MAS for all traits studied and that accuracy for GS reached a plateau at low marker densities (128–256).The average ratio of GS accuracy to phenotypic selection accuracy was 0.66, 0.54, and 0.42 for training population sizes of 96, 48, and 24, respectively. These results provide further empirical evidence that GS could produce greater genetic gain per unit time and cost than both phenotypic selection and conventional MAS in plant breeding with use of year‐round nurseries and inexpensive, high‐throughput genotyping technology.
Ferrocenyldiselenolate-Stabilized Copper−Selenium Clusters (2006)

The silylated ferrocenyl selenium reagent 1,1'-Fe(eta5-C5H4SeSiMe3)2 has been used for the high yield formation of the phosphine-ligated copper complexes Cu2(fcSe2)(PiPr3)2 (1) and Cu4(fcSe2)2(PnPr3)4 (2) from solublilized CuOAc, as determined by single-crystal X-ray diffraction. The incorporation of a source of Se2- into the reaction scheme with the reagent Se(SiMe3)2 yields the mixed selenide/ferrocenyldiselenolate cluster [Cu20Se6(Se2fc)4(PnPr3)10] (3). Partial substitution of the PnPr3 ligand shell in 3 with the phosphinothiol Ph2P(CH2)3SH leads to an expansion of the framework and the high yield formation of the crystallographically characterized cluster Cu36(fcSe2)6Se12(PnPr3)10(Ph2P(CH2)3SH)2 (5), which contains surface alkylthiol groups on a copper-selenium core.
Plasma immersion ion implantation (PIII): New path for optimizing doping profiles of advanced phosphorus emitters (2018)

A key step to achieve high conversion efficiencies for silicon solar cells is the junction formation. Plasma Immersion Ion Implantation (PIII) enables fine variations of the surface dopant concentration and depth of the doping profiles. Since no “dead-layer” with electrically inactive dopant species remains after an activation annealing step, high electrical quality of doped regions can easily be performed. We studied whether advanced Phosphorus emitters obtained via PIII could be optimized to increase p-type crystalline silicon (c-Si) solar cell performances. The doping profiles were tuned by changing ion dose and post implantation activation annealing temperature (Tanneal). A detailed analysis of carrier recombination in the different part of Al-BSF solar cells has been performed. Thus, saturation current densities (J0) were extracted (passivated emitter J0e,passivation, metallized emitter J0e,metallization, c-Si bulk and Back Surface Field J0,bulk+BSF) by coupling IC-QssPC and Suns-Voc measurements on specific test structures. An increase in Voc and Jsc was obtained by lowering the ion dose for a given Tanneal, whereas Voc, Jsc and the Fill Factor (FF) were improved by lowering Tanneal for a given dose. In the first case, photovoltaic (PV) conversion efficiencies did not change because of an increase in series resistance. However in the second case, they were increased by 0.2% absolute by reducing Tanneal from 850°C to 800°C, with a high FF value of 79.3% despite a relatively high emitter sheet resistance (115 Ω/square).
Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide Presentation on Dendritic Cells (1998)

Synthetic peptide-based vaccines have been shown to induce potent protective and therapeutic T cell-mediated immunity in preclinical animal models and are now being evaluated in clinical phase I/II studies for their efficacy against tumors or infectious diseases. However, such vaccines might also specifically tolerize T cells causing enhanced tumor outgrowth, as shown by vaccination with two CTL epitopes derived from the adenovirus type 5 early region 1 (Ad5E1) oncogenes. We now report that modification of the Ad5E1 peptide vaccine either through incorporation of the peptides into liposomes or by ligation of the peptides to lipid tails, another vaccine formulation being tested in the clinic, fails to convert immunosuppression into effective antitumor vaccination. Inclusion of a helper T cell epitope into the vaccine likewise induces enhanced tumor outgrowth and thus does not diminish the capacity of the peptides to tolerize Ad5E1-specific CTL. In contrast, the Ad5E1-derived peptides evoke a strong tumor-protective CTL response when presented on dendritic cells (DC), indicating that the in vivo CTL-tolerizing potential of these peptides is converted to specific immunostimulation when presented on DC. These findings have important implications for the development of peptide-based immune intervention strategies and emphasize the superior nature of Ag-pulsed DC over other peptide-based vaccination protocols as well as the crucial importance of the mode of peptide-Ag delivery in setting the balance between T cell stimulation and tolerization.
Acute Psychosis Triggered by Ovarian Teratoma: The Underdiagnosed yet Treatable Case of Anti-NMDA Receptor Encephalitis (2021)

Anti-NMDA receptor (NMDAR) encephalitis is a recently identified autoimmune disorder with prominent psychiatric symptoms. Patients usually present with acute behavioral change, psychosis, catatonic symptoms, memory deficits, seizures, dyskinesias and autonomic instability. In female patients an ovarian teratoma is often identified. We describe a 32-year-old woman who presented with acute psychosis. Shortly after admission, she developed generalized seizures and deteriorated into a catatonic state. Although ancillary tests including MRI, electroencephalogram and cerebrospinal fluid (CSF) analysis were unremarkable, the presentation of acute psychosis in combination with recurrent seizures and a relentless course suggested autoimmune encephalitis. The patient underwent pelvic ultrasound which disclosed an ovarian tumor, leading to an urgent cystectomy with pathological confirmation of a mature cystic ovarian teratoma. Plasmapheresis was then initiated, yielding partial response over the next two weeks. Following the detection of high titers of anti-NMDAR antibodies in the CSF, the patient ultimately received second line immunosuppressive treatment with rituximab. Over several months of cognitive rehabilitation, a profound improvement was eventually noted, although minor anterograde memory deficits remained. In this report we call attention to the inclusion of anti-NMDAR encephalitis in the differential diagnosis of acute psychosis. The inclusion of this disorder in the differential diagnosis is critical, as prompt initiation of immunotherapy and tumor removal, if appropriate, could dramatically affect outcome.
The effect of network promotions on consumers' purchasing behaviors (2011)

This paper divides the internet promotion into two categories, and analyses the consumer choices with different experience internet purchases adapting the method of researching investigation. In order to build market share, highlight distinct advantages and increase purchase rate of customer in the increasingly competitive market, the results of the research provide some advice to online retailer.
Thermodynamic analysis for rapid measurements of equilibrium adsorption from binary gas mixtures (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic analysis for rapid measurements of equilibrium adsorption from binary gas mixturesJames A. Ritter and Ralph T. YangCite this: Ind. Eng. Chem. Res. 1989, 28, 5, 599–608Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ie00089a016https://doi.org/10.1021/ie00089a016research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Estimation of Biological Signal Features Indicating Riding Comfort Changes by Trail Variation (2013)

In this paper, we aim to construct an evaluation method for bicycle-riding comfort using biological signals. In recent years, it has become important, in bicycle development companies (e.g., MIYATA CYCLE Co., Ltd.), to develop products by reflecting human sensibility in order to improve user satisfaction. In addition to conventional evaluation methods using acceleration, angular velocity, and questionnaires, we focus on the electromyogram (EMG) and the electroencephalogram (EEG) as new evaluation indexes. We analyze the EMG and the EEG to estimate the features of these biological signals and how they reflect changes in bicycle-riding comfort.