gebhart/patrepeval huggingface dataset:
Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms (2021)

The vascular complications have been a major cause of morbidity and mortality among all subtypes of BCR-ABL1 negative myeloproliferative neoplasms (MPN), but the ethnicity-specific data was limited. We therefore conducted a multi-center retrospective, longitudinal cohort study to evaluate the incidence, characteristics and risk factors of thromboembolic events of MPN patients. Of 256 patients, 27.3% experienced thromboembolic events, majority of which occurred before or within 12 months of MPN diagnosis. The multivariable Cox proportional analyses identified leukocytosis (HR 2.67, 95% CI 1.36-5.24, q = 0.004) and history of thrombosis (HR 9.68, 95% CI 2.00-46.88, q = 0.005) as the risk factors for thromboembolism. In subgroup analysis of polycythemia vera and hemoglobin concentration (HR 1.97, 95% CI 1.28-3.04, q = 0.002) appeared to be a significant risk factor of thrombosis, along with age and thrombosis history. In essential thrombocythemia, severity of the established IPSET score was closely correlated with the frequency of thromboembolic events. In primary myelofibrosis, history of thrombosis was associated with thrombosis events (HR 13.85, 95% CI 1.2-159.5, q = 0.035). Overall survival was worse in patients who experienced thromboembolic events. Our study highlighted the importance of recognizing high risk patients and implementing personalized intervention.
Abstract 19167: Can Variation of BNP Within the Normal Range Predict Mortality and Ischemic Events in a Secondary Prevention Population? Results From the Smart Cohort Prospective Registry Study (2010)

It is unclear whether variation of BNP levels within the normal range can predict long term mortality and cardiac ischemic events in secondary prevention population without heart failure. Methods and Results: Baseline BNP levels were measured in 2115 subjects (mean age 61±10 years, 81% male) with stable coronary artery disease (CAD) recruited in an outpatient clinic. During a mean follow-up of 4.0 years, the primary endpoint of cardiovascular (CV) mortality occurred in 145 (6.9%) patients. Total mortality occurred in 207 (9.8%) patients. Cardiac ischemic events (fatal and non-fatal acute MI, PCI and CABG) occurred in 410 (19.4%) patients. The low mortality rate (2%/year), the low median BNP level (12 pmol/L, IQR 6-24 pmol/L) and the low median hsCRP level (2 mg/L, IQR 1-4 mg/L) reflect the low risk profile of the population. BNP levels were positively associated with age (p=0.0001), CRP (p=0.01) and creatinine (p=0.0001) and inversely correlated with BMI (p=0.0001). They were higher in females (p=0.007), ...
Discussion about calculating locating-error of work piece in V profile locator (2002)

Based on modern works of processing and jig designing in our country,defferent locating basis and calculations methods of locating error are discussed,and then personal view is provided:applying definement of locating error and limit locations to calculate the errors of locating.
Purification and Characterization of Two Proteins from Culture Filtrates of Mycobacterium tuberculosis H 37 Ra Strain (1970)

Two proteins have been purified from culture filtrates of Mycobacterium tuberculosis, H(37)Ra strain by a procedure combining gel filtration, diethylaminoethyl (DEAE)-cellulose chromatography, and zone electrophoresis. The two proteins are similar in molecular weight but differ slightly in charge. The faster migrating protein, designated a(1), is not antigenic. The slower migrating protein, designated a(2), is antigenic both with respect to antisera and as a skin-testing antigen.
Advances in medicinal chemistry (1992)

Novel antipsychotics with unique D2/5-HT1A affinity and minimal extrapyramidal side effect liability, Allen B. Reitz, Malcoln K. Scott Antiplatelet and antithrombotic agents: from viper venom proteins, to peptides and peptidomimetics, to small organic molecules, Peter L.Barker, Robert R. Webb, II Discovery and preclinical development of the serotonin reuptake inhibitor sertraline, Willard M. Welch Boronic acid inhibitors of dipeptidylpeptidase IV: a new class of immunosuppressive agents, Roger J. Snow.
Segmentation and Recognition for Historical Tibetan Document Images (2020)

As a shining pearl in traditional Tibetan culture, historical Tibetan documents have received extensive attention from historians, linguists and Buddhist scholars. These documents are converted into digital form using Tibetan document segmentation and recognition methods. The document digitization is of great significance for the research, protection and inheritance of Tibetan history. This paper proposes an overall segmentation and recognition framework for historical Tibetan document images. Firstly, the historical Tibetan document image is preprocessed to correct imbalanced illumination, tilt and noises, and is further transformed into the binarized image. Secondly, we propose a layout segmentation method based on block projection to segment Tibetan document images into texts, lines and frames. Thirdly, in order to solve the problems of touching strokes between text-lines and curvilinear text-lines, we present a text-line segmentation method based on graph model for historical Tibetan text-line segmentation. Lastly, we present a touching segmentation method to segment touching Tibetan character string, and then recognize Tibetan characters. Experimental results show our proposed methods on layout segmentation, text-line segmentation and touching character string segmentation, achieve the satisfactory performance. The proposed methods can also be applied to other fonts in Tibetan font family.
Nanocomposite Manganese Oxides for Rechargeable Lithium Batteries (1999)

A nanocomposite strategy has been used successfully to maintain structural integrity and capacity retention in both the regions of the spinel oxide. The composite consists of intimately mixed nanometer‐size particles of the spinel oxide and . It exhibits a capacity of about in the range with excellent cyclability. The presence of small, strong grains of the electrochemically active helps to maintain structural integrity on cycling, which leads to excellent capacity retention for the spinel phase. ©1998 The Electrochemical Society
Does tumour size really affect the safety of laparoscopic partial nephrectomy? (2010)

• Laparoscopic partial nephrectomy for large tumours is feasible and has acceptable pathological results. However, the complication rate, in particular WIT, remains questionable. • Further studies are required to better clarify the role of LPN in the management of tumours of this size.
Levonorgestrel Intrauterine Device as an Endometrial Cancer Prevention Strategy in Obese Women (2016)

The levonorgestrel IUD is a potentially cost-effective strategy for prevention of deaths from endometrial cancer in obese women.
Novel view synthesis with light-weight view-dependent texture mapping for a stereoscopic HMD (2017)

The proliferation of off-the-shelf head-mounted displays (HMDs) let end-users enjoy virtual reality applications, some of which render a real-world scene using a novel view synthesis (NVS) technique. View-dependent texture mapping (VDTM) has been studied for NVS due to its photo-realistic quality. The VDTM technique renders a novel view by adaptively selecting textures from the most appropriate images. However, this process is computationally expensive because VDTM scans every captured image. For stereoscopic HMDs, the situation is much worse because we need to render novel views once for each eye, almost doubling the cost. This paper proposes light-weight VDTM tailored for an HMD. In order to reduce the computational cost in VDTM, our method leverages the overlapping fields of view between a stereoscopic pair of HMD images and pruning the images to be scanned. We show that the proposed method drastically accelerates the VDTM process without spoiling the image quality through a user study.
Primary Ovarian Borderline Tumor in the Inguinal Lymph Node (2013)

We report the case of a primary serous ovarian borderline tumour developed in an inguinal lymph node. No primary ovarian borderline tumour was observed within the ovaries after bilateral ovariectomy and complete pathological examination. We considered the diagnosis of ectopic ovarian tissue because the tumour was completely surrounded by normal ovarian tissue with positive FOXL2 staining. The whole ovarian tissue was itself entirely surrounded by lymphatic tissue. Two other hypotheses should be considered: primary retroperitoneal borderline tumour or retroperitoneal nodal involvement by an ovarian serous borderline tumour. Ectopic ovarian tissue can be observed in lymph node. We don't believe ectopic location of ovarian tissue increase the risk of neoplastic change.
ChemInform Abstract: Control of Product Selectivity by a Styrene Additive in Ruthenium‐Catalyzed C—H Arylation. (2011)

Abstract The selectivity in the mono‐ and disubstitution of acetophenones with aryl boronates (I) is investigated.
Modeling the structure of bound peptide ligands to major histocompatibility complex (2004)

In this article, we present a new technique for the rapid and precise docking of peptides to MHC class I and class II receptors. Our docking procedure consists of three steps: (1) peptide residues near the ends of the binding groove are docked by using an efficient pseudo-Brownian rigid body docking procedure followed by (2) loop closure of the intervening backbone structure by satisfaction of spatial constraints, and subsequently, (3) the refinement of the entire backbone and ligand interacting side chains and receptor side chains experiencing atomic clash at the MHC receptor-peptide interface. The method was tested by remodeling of 40 nonredundant complexes of at least 3.00 A resolution for which three-dimensional structural information is available and independently for docking peptides derived from 15 nonredundant complexes into a single template structure. In the first test, 33 out of 40 MHC class I and class II peptides and in the second test, 11 out of 15 MHC-peptide complexes were modeled with a Calpha RMSD < 1.00 A.
Zirconia <i>versus</i> titanium in dentistry: A review (2019)

This review scientifically compares the properties of zirconia and titanium, but does not identify the best among them as an implant material. Surface treatment and modification to improve tissue bonding and inhibit bacterial adhesion are not considered in this review. The mechanical properties of titanium are superior to those of zirconia; some studies have shown that zirconia can be used as a dental implant, especially as an abutment. Extensive surface treatment research is ongoing to inhibit bacterial adhesion and improve osseointegration and soft tissue adhesion phenomena which make it difficult to evaluate properties of the materials themselves without surface treatment. Osseointegration of titanium is superior to that of zirconia itself without surface treatment; after surface treatment, both materials show comparable osseointegration. The surface morphology is more important for osseointegration than the surface composition. To inhibit bacterial adhesion, zirconia is superior to titanium, and hence, more suitable for abutments. Both materials show similar capability for soft tissue adhesion.
Supplementary Table S2 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia (2023)

&lt;p&gt;Table S2: EnrichR analysis of FLT3 gene signatures&lt;/p&gt;
Image compression by CNN (2002)

This paper presents a very efficient image compression method well suited to the local nature of the CNN Universal Machine. In the case of lossless image compression it outperforms the JPEG image compression standard both in terms of compression efficiency and speed. It performs especially well with radiographical images (mammograms), therefore it is suggested that it could be used as part of a CNN based mammogram analysis system.
Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences (2022)

White-rot fungi secrete a repertoire of high-redox potential oxidoreductases to efficiently decompose lignin. Of these enzymes, versatile peroxidases (VPs) are the most promiscuous biocatalysts. VPs are attractive enzymes for research and industrial use but their recombinant production is extremely challenging. To date, only a single VP has been structurally characterized and optimized for recombinant functional expression, stability, and activity. Computational enzyme optimization methods can be applied to many enzymes in parallel but they require accurate structures. Here, we demonstrate that model structures computed by deep-learning-based <i>ab initio</i> structure prediction methods are reliable starting points for one-shot PROSS stability-design calculations. Four designed VPs encoding as many as 43 mutations relative to the wildtype enzymes are functionally expressed in yeast, whereas their wildtype parents are not. Three of these designs exhibit substantial and useful diversity in their reactivity profiles and tolerance to environmental conditions. The reliability of the new generation of structure predictors and design methods increases the scale and scope of computational enzyme optimization, enabling efficient discovery and exploitation of the functional diversity in natural enzyme families directly from genomic databases.
In-flight flow visualization using infrared imaging (1988)

A flight test investigation was conducted to evaluate infrared (IR) flow imaging techniques for boundary-layer flow visualization. The flight tests used a single-engine turboprop aircraft with a fiberglass-skinned natural laminar flow glove mounted on the left wing and an infrared imaging system to obtain flow visualization data. Data were compared to results obtained from other more conventional boundary-layer flow visualization methods and found to agree well. Test flights were conducted to determine the effect of test surface color on IR flow visualization results. In addition, flights were made during both night and daylight hours to assess the effect of solar radiation on the results. The investigation included an effort to visualize a vortex passing over the wing glove, but the tests provided only limited results.
Development of the 3-Dimensional CAD System for Injection Mold Design (1st Report) (1985)

SMDS which stands for Sony Mold Design Simulator has been developed as a part of an integrated CAD system for injection mold design. This paper describes the prototype system of SMDS, and some examples that are applied to the actual injection mold design are presented. SMDS has been developed to realize the system that can process the geometric data of a mold, based on CSG solid modeler TIPS-1 system. However, there are some future subjects, i.e., physical analysis, simulation of mold flow and so on. These problems should be solved using the model generated in SMDS in the near future. In SMDS, the process of mold design is done by interactive operations and several useful functions for mold design, i.e., shrinkage process, automatic generation of cavity and core, drafting process, and dimensioning and tolerancing, are prepared. Additionally, SMDS has an interface to a 2-D drafting system that can generate complete drafts using interactive operations.
Meckel diverticulum: radiologic demonstration by enteroclysis (1980)

Thirteen patients with surgically confirmed Meckel diverticula encountered in a 30 month period are reported. Of 11 symptomatic patients, all had lower gastrointestinal bleeding, except one who had recurrent abdominal pain only. Two diverticula were incidental, coexisting with Crohn disease of the distal ileum. One of these had occasional diarrhea and hematochezia. The diagnosis was established preoperatively by enteroclysis in 11 of these cases. The enterographic demonstration of the mucosal triangular plateau or the triradiate fold pattern indicating the site of exit of the omphalomesenteric duct should lead to a diagnosis of Meckel diverticulum. Pitfalls in interpretation due to the pseudotriangular plateau appearance formed by superimposition of two intestinal loops and the pseudosaccule produced by the axial projection of a fixed loop of bowel and the differential diagnosis are discussed. Enteroclysis seems to be the most dependable method currently available for preoperative demonstration of Meckel diverticulum.
A Particle Swarm Optimization approach of the Axial Apodization problem (2017)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Cognard, N. Devaney, and C. Dainty, "A Particle Swarm Optimization approach of the Axial Apodization problem," in Imaging and Applied Optics 2017 (3D, AIO, COSI, IS, MATH, pcAOP), OSA Technical Digest (online) (Optica Publishing Group, 2017), paper JTu5A.24. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Thermophysical properties on biological tissue. (1990)

最近の医療技術には、 生体の熱現象を利用する方法が増えているため、 生体組織内の伝熱の様子を明らかにする必要が高まっている。 そのため、 信頼性の高い生体組織の熱物性値の測定方法が開発され、 さらに生体組織の微視的構築が明らかになるとともに、 組織内の伝熱のメカニズムも次第に明確になって来た。 本稿では、 熱物性を中心とした生体組織内の伝熱の研究の進展について概観する。
Comparison Of Tooth Size Discrepancy Of Three Main Ethnics In Malaysia With Bolton'S Ratio (2014)

The objective of this study was to investigate the applicability of Bolton's ratios in orthodontic population of Malaysian main ethnics; Malay, Chinese and Indians. Ninety convenient samples consisting of 30 pre-orthodontic study casts from each ethnic that fits the inclusion criteria were selected. The greatest mesiodistal widths of each tooth from six to six for overall ratio and three to three for anterior ratio were measured using a digital callipers linked to Hamilton Arch Tooth System software to the nearest 0.01mm. Means of the ratios were calculated using Bolton analysis. One sample t-test statistic analysis was carried out to compare the means with Bolton values of anterior ratio and overall ratio and one-way ANOVA was used to analyze comparison between ethnic groups of the anterior ratio and the overall ratio with the level of statistical significance set at p &lt; 0.05. However, there were no significant differences when comparing Bolton values with Chinese and Indian anterior and overall ratios. The Bolton standards could be applied to Malaysian Chinese, Indians and Malay's female. Subsequently, a specific standard should be used for the Malays orthodontic population.
Bioremediation in Urban Pollution Mitigation: Applications to Solid Media (2018)

Contaminated land remains both a barrier to the redevelopment of urban areas and a threat to the wider environment. This chapter concentrates on the applications of bioremediation to the clean-up of solid substrates, both as a means of allowing redevelopment and also to prevent ongoing groundwater pollution. It examines both oxidative and reductive mechanisms. In situ approaches tend to be undertaken when the contamination is at great depth, with little space available, and in some cases, where the site must be kept in use during the process. Enhanced bioremediation of soil typically involves the percolation or injection of water mixed with nutrients, saturated with dissolved oxygen, or provided with another electron acceptor. An in situ soil remediation technique which attempts, in a limited way, to mitigate against this heterogeneity, known as landfarming, has been used in the petroleum industry for many years.
A Comparison of Controlled Negative Pressure and Aerosol Quantitative Respirator Fit Test Systems by Using Fixed Leaks (1991)

An automated version of a new method for quantitative respirator fit testing by controlled negative pressure was compared with a computerized aerosol fit test system. The controlled negative pressure technique eliminates many of the problems associated with aerosol and pressure decay fit test methods. A series of fixed leaks was used to compare the leak measurement capabilities of the controlled negative pressure system against a standard computerized aerosol fit test system. Negative pressure and aerosol fit factors determined for a series of fixed leaks through hypodermic needles were highly correlated with each other (r=0.998) and with the cross-sectional areas of the leak needles (r>0.995).
Spatial Modulation (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Spatial modulation (SM) is a recently developed transmission technique that uses multiple antennas. The basic idea is to map a block of information bits to two information carrying units: 1) a symbol that was chosen from a constellation diagram and 2) a unique transmit antenna number that was chosen from a set of transmit antennas. The use of the transmit antenna number as an information-bearing unit increases the overall spectral efficiency by the base-two logarithm of the number of transmit antennas. At the receiver, a maximum receive ratio combining algorithm is used to retrieve the transmitted block of information bits. Here, we apply SM to orthogonal frequency division multiplexing (OFDM) transmission. We develop an analytical approach for symbol error ratio (SER) analysis of the SM algorithm in independent identically distributed (i.i.d.) Rayleigh channels. The analytical and simulation results closely match. The performance and the receiver complexity of the SM–OFDM technique are compared to those of the vertical Bell Labs layered space–time (V-BLAST–OFDM) and Alamouti–OFDM algorithms. V-BLAST uses minimum mean square error (MMSE) detection with ordered successive interference cancellation. The combined effect of spatial correlation, mutual antenna coupling, and Rician fading on both coded and uncoded systems are presented. It is shown that, for the same spectral efficiency, SM results in a reduction of around 90% in receiver complexity as compared to V-BLAST and nearly the same receiver complexity as Alamouti. In addition, we show that SM achieves better performance in all studied channel conditions, as compared with other techniques. It is also shown to efficiently work for any configuration of transmit and receive antennas, even for the case of fewer receive antennas than transmit antennas. </para>
Dependency of Head Impact Rotation on Head-Neck Positioning and Soft Tissue Forces (2018)

This analysis quantifies the importance of head positioning prior to impact, and may help us to explain why other species are naturally more resilient to head impacts than humans.
Repeated corticosterone administration increases excitatory effect of 5-HT4 receptor agonist in the rat hippocampus. (2001)

The objective of the present study was to investigate whether repeated exposure of rats to high level of corticosterone affects responses of CA1 hippocampal cells to the 5-HT4 receptor agonist zacopride. To assess responsiveness of CA1 neurons to zacopride we used extracellular recording of population spikes evoked in CA1 cells by the stimulation of the Schaffer/collateral-commissural pathway in hippocampal slices. Rats were treated with corticosterone for 7 days (10 mg/kg sc, twice daily), slices were prepared two days after the last treatment. Zacopride induced an increase in the amplitude of population spike and repeated corticosterone treatment enhanced this excitatory effect. It is concluded that repeated treatment with corticosterone increases the responsiveness of hippocampal CA1 neurons to the 5-HT4 receptor activation.