gebhart/patrepeval huggingface dataset:
Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub (2018)

Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none responses, yet TLR activation by diverse microbes induces anything from mild to severe inflammation. Using single-molecule imaging of TLR4-MyDDosome signaling in living macrophages, we find that MyDDosomes assemble within minutes of TLR4 stimulation. TLR4/MD2 activation leads only to formation of TLR4/MD2 heterotetramers, but not oligomers, suggesting a stoichiometric mismatch between activated receptors and MyDDosomes. The strength of TLR4 signalling depends not only on the number and size of MyDDosomes formed but also how quickly these structures assemble. Activated TLR4, therefore, acts transiently nucleating assembly of MyDDosomes, a process that is uncoupled from receptor activation. These data explain how the oncogenic mutation of MyD88 (L265P) assembles MyDDosomes in the absence of receptor activation to cause constitutive activation of pro-survival NF-κB signalling.
HogMap (2016)

Cyber Threat Intelligence (CTI) sharing facilitates a comprehensive understanding of adversary activity and enables enterprise networks to prioritize their cyber defense technologies. To that end, we introduce HogMap, a novel software-defined infrastructure that simplifies and incentivizes collaborative measurement and monitoring of cyber-threat activity. HogMap proposes to transform the cyber-threat monitoring landscape by integrating several novel SDN-enabled capabilities: (i) intelligent in-place filtering of malicious traffic, (ii) dynamic migration of interesting and extraordinary traffic and (iii) a software-defined marketplace where various parties can opportunistically subscribe to and publish cyber-threat intelligence services in a flexible manner.
Generation of the Dianion from Tetrasilabicyclo[1.1.0]butane Derivatives (1987)

Abstract Reductive cyclization of R2ClSi–SiCl2R′ with 5 equiv. of lithium naphthalenide followed by aqueous workup provides the corresponding cyclotetrasilane [(R2SiSiHR′)2]. Similar treatment converts RCl2SiSiClHR into a stereoisomeric mixture of cyclotetrasilanes [(RHSi)4]. Evidence is presented to indicate that the tetrasilabicyclo[1.1.0]butane derivatives formed as intermediates in these reactions are transformed into the dianions corresponding to the products.
Collection efficiencies of an electrostatic sampler with superhydrophobic surface for fungal bioaerosols (2010)

The new electrostatic precipitator with superhydrophobic surface (EPSS) collects airborne fungal spores into small water droplets (10 and 40 μl) allowing achievement of concentration rates that are higher than those of most currently available bioaerosol samplers. Biosamplers with high concentration rates enable detection of low ambient aerial bioaerosol concentrations in various environments, including indoors air, and would be useful for improved exposure assessment. A successful adaptation of the adenosine triphosphate (ATP)-based bioluminescence assay for the quantification of fungal spores from a specific species enables fast sample analysis in laboratory investigations. This rapid assay could be especially useful when investigating the performance of biological samplers as a function of multiple operational parameters.
Variational Framework for Non-Local Inpainting (2015)

Image inpainting aims to obtain a visually plausible image interpolation in a region of the image in which data is missing due to damage or occlusion. Usually, the only available information is the portion of the image outside the inpainting domain. Besides its numerous applications,the inpainting problem is of theoretical interest since its analysis involves an understanding of the self-similarity present in natural images. In this work, we present a detailed description and implementation of three exemplar-based inpainting methods derived from the variational framework introduced by Arias et al.
RNR2 repression by p21 restricts reverse transcription of HIV-1 and related-lentiviruses in macrophages (2013)

International audience
Chemical vapor deposition graphene as structural template to control interfacial molecular orientation of chloroaluminium phthalocyanine (2011)

Chemical vapor deposition (CVD) graphene has been used as an effective structural template to manipulate molecular orientation of organic thin film of chloroaluminium phthalocyanine (ClAlPc) on indium tin oxide (ITO) electrode. As revealed by in-situ near-edge x-ray adsorption fine structure measurement, ClAlPc molecules on the CVD graphene modified ITO electrode adopt a well-aligned lying-down configuration with their molecular π-plane nearly parallel to the electrode surface, in contrast to the random orientation of ClAlPc molecules on the bare ITO electrode. This lying-down configuration results in an optimized stacking of the molecular π-plane perpendicular to the electrode surface and hence facilitates efficient charge transport along this direction.
Novel therapies for resistant focal segmental glomerulosclerosis (FONT) phase II clinical trial: study design (2019)

Abstract Background The lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in patients who fail to respond to corticosteroids and immunosuppressive therapies. Recent basic science advances have led to development of alternative treatments that specifically target aberrant pathways of fibrosis which are relevant to disease progression in FSGS. There is a need for a flexible Phase II study design which will test such novel antifibrotic strategies in order to identify agents suitable for phase III testing. Methods/Design The Novel Therapies for Resistant Focal Segmental Glomerulosclerosis (FONT) project is a multicenter Phase I/II RCT designed to investigate the potential efficacy of novel therapies for resistant FSGS. Adalimumab and galactose will be evaluated against conservative therapy consisting of the combination of lisinopril, losartan and atorvastatin. The sample size is defined to assure that if one of the treatments has a superior response rate compared to that of the other treatments, it will be selected with high probability for further evaluation. Comparison of primary and secondary endpoints in each study arm will enable a choice to be made of which treatments are worthy of further study in future Phase III RCT. Discussion This report highlights the key features of the FONT II RCT including the two-step outcome analysis that will expedite achievement of the study objectives. The proposed phase II study design will help to identify promising agents for further testing while excluding ineffective agents. This staged approach can help to prevent large expenditures on unworthy therapeutic agents in the management of serious but rare kidney diseases Trial Registration ClinicalTrials.gov, NCT00814255
Distribution of Membrane Phospholipids in the Rabbit Uvea (1995)

This study establishes baseline PL profiles of the uveal tract tissues and will permit comparisons with tissues from eyes with inflammatory disorders. The PL concentrations in conjunction with the indexes demonstrate that overall the choroid has membranes that are less permeable to ion translocation than either the iris or the ciliary body, although there are compensatory concentration changes between the SM and PC components among these three tissues.
A Systems-Based Analysis of Mono- and Combination Therapy for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections (2022)

Antimicrobial resistance is a global threat. As "proof-of-concept," we employed a system-based approach to identify patient, bacterial, and drug variables contributing to mortality in patients with carbapenem-resistant Klebsiella pneumoniae (CR<i>Kp</i>) bloodstream infections exposed to colistin (COL) and ceftazidime-avibactam (CAZ/AVI) as mono- or combination therapies. Patients (<i>n</i> = 49) and CR<i>Kp</i> isolates (<i>n</i> = 22) were part of the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE-1), a multicenter, observational, prospective study of patients with carbapenem-resistant Enterobacterales (CRE) conducted between 2011 and 2016. Pharmacodynamic activity of mono- and combination drug concentrations was evaluated over 24 h using <i>in vitro</i> static time-kill assays. Bacterial growth and killing dynamics were estimated with a mechanism-based model. Random Forest was used to rank variables important for predicting 30-day mortality. Isolates exposed to COL+CAZ/AVI had enhanced early bacterial killing compared to CAZ/AVI alone and fewer incidences of regrowth compared to COL and CAZ/AVI. The mean coefficient of determination (R<sup>2</sup>) for the observed versus predicted bacterial counts was 0.86 (range: 0.75 - 0.95). Bacterial subpopulation susceptibilities and drug mechanistic synergy were essential to describe bacterial killing and growth dynamics. The combination of clinical (hypotension), bacterial (IncR plasmid, <i>aadA2</i>, and <i>sul3</i>) and drug (KC<sub>50</sub>) variables were most predictive of 30-day mortality. This proof-of-concept study combined clinical, bacterial, and drug variables in a unified model to evaluate clinical outcomes.
The immunoregulatory effect of TLSFJM on the expression of T cell IL-2R and protein tyrosine phosphorylation (1991)

The immunoregulatory effect of TLSFJM on the expression of T cell IL- 2R and protein tyrosine phosphorylation ( FTP ) was investigated by immunohistochemistry technique. The results showed that TLSFJM can markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSFJM on the production of IL-1, IL-2 and IL-6 that play an important role in the course of T lymphocyte proliferation and differentiation.
Plutôt somnolent ou plutôt fatigué ?: Fatigue,somnolence, plaintes de sommeil et symptômes affectifs dans un échantillon de la population générale belge francophone (2008)

6e Congrès de l'Encéphale, Paris, 24-26 Janvier 2008
Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure (2017)

Qishenkeli (QSKL) is one of the Chinese medicine formulae for treating heart failure and has been shown to have an antifibrotic effect. However, the mechanism of its therapeutic effects remains unclear. In this study, we aimed to explore whether QSKL could exert an antifibrotic effect by attenuating ras homolog family member A (RhoA) and mitogen activated protein kinase (MAPK) pathways. Rats were randomly divided into sham group, model group, QSKL group, and positive control group. Heart failure was induced by ligation of the left ventricle anterior descending artery. Cardiac functions were measured by echocardiography and collagen deposition was assessed by Masson staining. Expressions of the key molecules involved in the RhoA and MAPK pathways were also measured. Twenty-one days after surgery, cardiac functions were severely impaired and collagen deposition was remarkable, while QSKL treatment could improve heart functions and alleviate collagen deposition. Further results demonstrated that the effects may be mediated by suppressing expressions of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). Moreover, expressions of RhoA, Rho-associated protein kinase 1/2 (ROCK1/2), and phosphorylated myosin light chain (p-MLC) were also downregulated by QSKL compared with the model group. The cardioprotective mechanism of QSKL on heart failure is probably mediated by regulating both the MAPK and RhoA signaling pathways.
TERO-Based Detection of Hardware Trojans on FPGA Implementation of the AES Algorithm (2016)

A Transient Effect Ring Oscillator (TERO) is a special case of a Ring Oscillator (RO) design that exhibits increased sensitivity to intrinsic noise. It can serve as a basis for implementing a True Random Number Generator (TRNG) or a Physically Uncloneable Function (PUF). Also, as a digital sensor for detecting insertion of malicious hardware logic (Trojans) in digital circuits. Here, we explore the application of TERO for detecting hardware Trojans injected in FPGA implementations of the AES cryptographic algorithm. Experiments and comparisons are reported in terms of the frequency as a function of the TERO length. Our findings indicate that TERO-based digital sensors can be used to efficiently detect the presence of the Trojan.
Role-based access control for collaborative enterprise in peer-to-peer computing environments (2003)

In Peer-to-Peer (P2P) computing environments, each participant (peer) acts as both client and content provider. This satisfies the requirement that resources should be increasingly made available by being published to other users from a user's machine. Compared with services performed by the client-server model, P2P-based services have several advantages. However, wide-scale application of P2P computing is constrained by limitations associated with the especially sophisticated control mechanisms needed between peers. To overcome these limitations, we introduce a controlled P2P computing architecture by extending the concept of Web services to the peer-to-peer level through a generic middleware. Specifically, in this paper we tailor our approach to support RBAC. Although our approach supports both brokered and purist P2P models, all of the policy decisions can be made on the peer side, because policy information is transferred from the policy servers to the corresponding peers through metadata that peers can understand. Each peer makes the access control decision based on the enterprise, the community, and the peer policies without asking other components. This approach supports RBAC services for collaborative enterprise in P2P computing environments, not only within one community but also within inter-communities. Furthermore, it also supports peers' autonomous decisions without causing policy conflicts. The broad dissemination of our approach would enable P2P technology to be applicable to more reliable and efficient services, providing controlled communications between peers.
Geometrical Building Modeling and Its Application to the Ortho-Rectification for Aerial Images (2004)

Due to the huge demand and the importance of 3-D city models, an effective solution for geometrical building modeling is indispensable. From the application point of view, an interactive system for geometrical building modeling based on a semi-automatic approach is presented. A true-orthophoto rectification scheme based on the generated building models is also proposed. The data used in the proposed system are 3-D visible roof-edges that have been manually measured from a stereo-model, or the 3-D building outlines from a digital topographic map. The core technology is called the”Split-Merge-Shape”(SMS) method. The SPLIT and MERGE steps are the two main procedures for topology reconstruction from non-related roof-edges. The SHAPE step uses the available roof-edge height information to define an appropriate rooftop. With the SMS method, the topographic mapping of buildings, and geometric building modeling, can be seamlessly integrated into a unified procedure.
In a conventional ortho-rectification procedure using a digital terrain model, the correction of relief displacement due to buildings is not considered. In order to restore the most complete information and to correct the relief displacement of buildings, a rigorous true-orthophoto rectification scheme is proposed. In the proposed scheme, 3-D building models, multi-view aerial images, digital terrain models, and the sun's orientation are all utilized. Terrain and building relief displacement corrections as well as hidden area compensation, seamless mosaicking, and shadowed area enhancement are integrated into one procedure. In this paper, the SMS method is presented, including an evaluation of its feasibility, robustness, efficiency and accuracy. Finally, the generated building models are applied to true-orthophoto generation and 3-D GIS querying.
Specific control of immunity by regulatory CD8 T cells. (2005)

T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.
The Effect of Stem Fit on Bone Hypertrophy and Pain Relief in Cementless Total Hip Arthroplasty (1989)

This study was designed to clinically evaluate the effects of a tight distal fit and collar seating in hips with a cylindrical distal stem, collar, and proximal porous coating. A clinical assessment of pain and a roentgenographic assessment of patterns of proximal femoral hypertrophy were made in 105 patients. Intraoperative evaluations of the distal stem fit were performed so that a tight distal fit was ensured in 67 patients. Thirty-eight patients who did not have intraoperative sizing were determined roentgenographically to have a loose distal fit. Pain was significantly more likely to occur in those patients with a loose distal fit (20 of 38) than in those with a tight distal fit (two of 67). Collar seating was associated with hypertrophy under the seated portion of the collar in all cases, and failure to seat the collar was associated with recession and rounding of the upper femoral cortical edge. Distal hypertrophy occurred in 24 of the 67 hips with a tight distal fit, and a tight distal fit did not prevent proximal hypertrophy. It was concluded that a tight distal fit is associated with more complete pain relief in cementless total hip arthroplasty and that a tight distal fit of a cylindrical stem does not prevent proximal load bearing.
{311} defect evolution in ion-implanted, relaxed Si1−xGex (2004)

Si-implanted, unstrained Si1−xGex layers of various Ge concentrations ranging from 0% to 50% were grown by molecular beam epitaxy on top of a Si substrate. The samples were subjected to a 750 °C anneal for 180 min to explore the subsequent defect structure. Plan-view transmission electron microscopy was implemented to investigate the evolution of defects. The Si1−xGex samples with ⩽5% Ge exhibit {311} defect formation and dissolution, and these defects ripen throughout the course of the anneal. Increasing the Ge content has an adverse effect on the growth of {311} defects. The samples with Ge contents ⩾25% demonstrated only dislocation loop formation. Dislocation loop formation and the observed impedance of {311} defect growth is facilitated by increasing the Ge content due to the weak bonding associated with the Ge atoms.
Dielectric model for Chinese hamster ovary cells obtained by dielectrophoresis cytometry (2016)

We present a dielectric model and its parameters for Chinese hamster ovary (CHO) cells based on a double-shell structure which includes the cell membrane, cytoplasm, nuclear envelope, and nucleoplasm. Employing a dielectrophoresis (DEP) based technique and a microfluidic system, the DEP response of many single CHO cells is measured and the spectrum of the Clausius-Mossotti factor is obtained. The dielectric parameters of the model are then extracted by curve-fitting to the measured spectral data. Using this approach over the 0.6-10 MHz frequency range, we report the values for CHO cells' membrane permittivity, membrane thickness, cytoplasm conductivity, nuclear envelope permittivity, and nucleoplasm conductivity. The size of the cell and its nuclei are obtained using optical techniques.
Action recognition with various speeds and timed-DMHI feature vectors (2008)

Usually, various motion recognition approaches can not perform well on actions that have variable speeds, or part of the dataset is speedy and vice versa. In this paper, we present the timing issue of our Directional Motion History Image method. This method can solve overwriting or motion self-occlusion problem significantly and thereby it performs well for complex and repetitive activities. However, it is important to analyze the method with activities having various speeds to show its robustness. The experimental results demonstrate that it can perform well with variable paces of the actions though the recognition rate is compromised a bit compared to the dataset having usual speed. We also improve the classification method with the incorporation of motion duration in the final feature vector so that for similar type of activities having different pace, it can show better result. Experiments on another dataset show better performance with the timing incorporation. The achieved recognition rates are very encouraging for further research and implementation is some intelligent systems for surveillance and related applications.
Pragmatic, double-blind, randomised trial evaluating the impact of red blood cell donor sex on recipient mortality in an academic hospital population: the innovative Trial Assessing Donor Sex (iTADS) protocol (2021)

NCT03344887; Pre-results.
Fluorescence spectrometer for a single electrodynamically levitated microparticle (1986)

A spectrometer for measuring the fluorescence emission from a single trapped aerosol particle is described. This device consists of a particle generator, an electrodynamic levitator, an excitation source, and detection optics and electronics. Provision is made to cool the sample chamber, and spectra can be obtained in real time. Typical spectra from particles containing organic laser dyes are presented.
Comparative study of the in vitro sensitivity of Plasmodium falciparum to artemisinin in two border areas of Thailand. (2004)

Artesunate was introduced in Thailand in 1995 for the treatment of falciparum malaria in areas of multidrug resistance, where it is used in combination with mefloquine. The studies were conducted between May and August 1999, 2000 and 2001 in the provinces Mae Hong Son and Tak (Mae Sot District) in northwestern Thailand, both on the border to Myanmar. The province of Mae Hong Son is still largely unaffected by multidrug resistance and infections with Plasmodium falciparum are treated with mefloquine alone. In the district of Mae Sot, 350 km southwards, more than 60% of the Plasmodium falciparum isolates were found to be resistant to mefloquine. Between 1999 and 2001, a total of 227 fresh isolates of Plasmodium falciparum were successfully tested for their sensitivity to artemisinin using the WHO standard in vitro microtest. The weighted mean EC5o and EC90 values for 1999-2001 were 9.20 nM and 34.37 nM in Mae Hong Son and 11.18nM and 71.63nM in Mae Sot, respectively. The comparison of the sensitivity to artemisinin between Mae Hong Son and Mae Sot showed no significant difference in 1999, but significant differences in 2000 (p<0.05) and in 2001 (p<0.01). This phenomenon could be a consequence of different drug pressure. Furthermore, the lower sensitivity of Plasmodium falciparum to mefloquine in Mae Sot may play a minor (but amplifying) role, as the activities of artemisinin and mefloquine show a significant correlation.