gebhart/patrepeval huggingface dataset:
Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog. (1978)

The hemodynamic effects of 7 min i.v. sodium nitroprusside (NP) were studied in conscious dogs previously instrumented for measurement of arterial pressure, cardiac output, regional blood flow distribution, left ventricular (LV) pressure, and internal dimensions. Nitroprusside, 25 microgram/kg/min, reduced mean arterial pressure by 23 +/- 3%. Cardiac output increased initially by 39 +/- 7% and returned toward control by the end of the infusion. Regional blood flows increased initially; the relative rise was greatest in the coronary (+ 225 +/- 39%), intermediate in the mesenteric (+ 98 +/- 23%) and iliac (+ 38 +/- 6%), and least in the renal (+ 10 +/- 3%) bed. By the end of the infusion period the vasodilation was unchanged in the iliac bed, less intense in the coronary and mesenteric, while in the iliac bed, blood flow was reduced and resistance was actually increased by 33 +/- 11% above control. A generalized vasonconstriction ensued after cessation of infusion. In contrast, when the drug was administered intra-arterially to the iliac bed, arterial pressure did not fall and only iliac vasodilation was observed. Peak cardiac effects were characterized by increases in heart rate and LV dP/dt, along with marked reduction in LV end-systolic diameter (- 13 +/- 2%), and in end-diastolic diameter (-17 +/- 2%) and pressure. LV end-diastolic diameter fell even heart rate was maintained at a constant rate by pacing. Thus, in the conscious dog, NP reduced LV dimensions substantially, while inducing changes in peripheral beds. The differences in these effects depend on interactions between the direct effects of NP and the opposing effects of reflex adjustments which appear sufficiently powerful to result in net constriction of the iliac bed late during the infusion.
ChemInform Abstract: Conformational Effects on High‐Spin Organic Molecules (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Aktuelle Strategien zur Behandlung der CMV-Retinitis bei Patienten mit AIDS (1999)

Effective treatment of clinically resistant CMV retinitis must consider the individual conditions. Thus, it is probable, that integration of both local and systemic therapies may be required to reduce the frequency of reactivation and thereby to decelerate the progression of the disease. Literature search in medline.
Studies on the Flow Characteristics of the High Speed Water Jets in Air (1977)

In the present paper, for the purpose of considering the performance of nozzle of the hydraulic cutting device and mechanism of the hydraulic fracturing, the authors investigated theoretically and experimentally the fl ow characteristics of continuous water jets issuing into a quiescent air ambient.The analytical relations of momentum theory are proposed on experimental fi ndings for the width of jet spread. The pattern of the jet spread is proved by means of the electric method, the Pitot tube method, the photographic method. Further the jet velocity of center line is determined by means of the laser velocimeter method. Water jets are characterized by three distinct regions, potential core region, transitional region and main region.The good agreement between the experimental and theoretical values of axial fluid pressure in a water jet is obtained under the condition that the transitional region is taken into account in the calculations.
Synchronous generator field excitation via capacitive coupling through a journal bearing (2016)

Wound field synchronous generators (WFSG) are the standard for back-up and utility scale power generation. Rotor field current and prime mover speed are the only control parameters required to regulate power conversion in a generator application. Maintenance costs may be minimized by adopting non-contact or “brushless” technologies to replace sliding slip ring connections. This paper presents a brushless excitation approach using ceramic insulated sleeve (journal) bearings with oil lubrication to form capacitively coupled slip rings, in contrast to more traditional inductive brushless exciters and rotary transformers. This capacitive power transfer (CPT) approach exhibits advantages including low weight, low volume and has a relatively simple construction using off-the-self components. Analysis, design and prototype construction of the CPT system are presented. Experimental results demonstrate that ~1.7nF of capacitive coupling transfers 340W to the rotor field winding of a 10kW 208V WFSG. Voltage regulation of a WFSG is demonstrated during steady state and 1 per unit load step changes yielding a NEMA-MG1 class G2 rating.
lnterleukin-3 Immunoassay in Systemic Lupus Erythematosus Patients: Preliminary Data (1993)

Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the proliferation and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to health controls. The IL-3 levels were highest in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.
An on-chip active decoupling circuit to suppress crosstalk in deep-submicron CMOS mixed-signal SoCs (2005)

A decoupling circuit using an operational amplifier is proposed to suppress substrate crosstalk in mixed-signal system-on-chip (SoC) devices. It overcomes the parasitic inductance problem of on-chip capacitor decoupling. The effect of the proposed decoupling circuit is not limited by parasitic fine impedance. A 0.13-/spl mu/m CMOS test chip showed that substrate noise at frequencies from 40 MHz to 1 GHz was incrementally suppressed by sequentially activating three of the proposed circuits in parallel. The power dissipation of each circuit was 3.3 mW at a 1.0-V power supply. The test chip measurement showed that the proposed decoupling reduced crosstalk by 31% at 200 MHz, whereas it was reduced by 4.4% with capacitor decoupling. This 7:1 ratio, or 17 dB, corresponds to the gain of the opamp. Design of the opamp and its feedback loop for active decoupling is simple, making the opamp useful for SoC applications.
Kinematic soil–structure interaction for long‐span cable‐supported bridges (1993)

Abstract A general procedure is presented to study the dynamic soil–structure interaction effects on the response of long‐span suspension and cable‐stayed bridges subjected to spatially varying ground motion at the supporting foundations. The foundation system is represented by multiple embedded cassion foundations and the frequency‐dependent impedance matrix for the multiple foundations system takes into account also the cross‐interaction among adjacent foundations through the soil. To illustrate the potential implementation of the analysis, a numerical example is presented in which the dynamic response of the Vincent–Thomas suspension bridge (Los Angeles, CA) subjected to the 1987 Whittier earthquake is investigated. Although both kinematic and inertial effects are included in the general procedure, only the kinematic effects of the soil–structure interaction are considered in the analysis of the test case. The results show the importance of the kinematic soil–foundation interaction on the structural response. These effects are related to the type, i.e. SH‐, SV‐, P‐ or Rayleigh waves and to the inclination of the seismic wave excitation. Moreover, rocking components of the foundation motion are emphasized by the embedment of the foundation system and greatly alter the structural response.
Effects of the relative timing of opposite-polarity pulses on loudness for cochlear implant listeners (2018)

The symmetric biphasic pulses used in contemporary cochlear implants (CIs) consist of both cathodic and anodic currents, which may stimulate different sites on spiral ganglion neurons and, potentially, interact with each other. The effect on the order of anodic and cathodic stimulation on loudness at short inter-pulse intervals (IPIs; 0-800 <i>μ</i>s) is investigated. Pairs of opposite-polarity pseudomonophasic (PS) pulses were used and the amplitude of each pulse was manipulated independently. In experiment 1 the two PS pulses differed in their current level in order to elicit the same loudness when presented separately. Six users of the Advanced Bionics CI (Valencia, CA) loudness-ranked trains of the pulse pairs using a midpoint-comparison procedure. Stimuli with anodic-leading polarity were louder than those with cathodic-leading polarity for IPIs shorter than 400 <i>μ</i>s. This effect was small-about 0.3 dB-but consistent across listeners. When the same procedure was repeated with both PS pulses having the same current level (experiment 2), anodic-leading stimuli were still louder than cathodic-leading stimuli at very short intervals. However, when using symmetric biphasic pulses (experiment 3) the effect disappeared at short intervals and reversed at long intervals. Possible peripheral sources of such polarity interactions are discussed.
Local Control of cis-Peptidyl–Prolyl Bonds Mediated by CH···π Interactions: The Xaa-Pro-Tyr Motif (2013)

Compared to generic peptide bonds, the peptidyl-prolyl bond shows a strong propensity for the cis conformer. The presence of a sequence-contiguous aromatic (Aro) residue can further stabilize the cis conformer, as observed for the Aro-Pro motif. The cis propensity of the reverse sequence motif, Pro-Aro, is not so well understood, especially the effect of N-capping the Pro-Aro motif with different amino acid residues. From a comparative nuclear magnetic resonance study of two peptide series with the general sequences Ac-Xaa-Pro-Tyr-NH2 and Ac-Xaa-Pro-Ala-NH2, we present a relative thermodynamic scale that reflects how the nature of the Xaa side chain influences the cis propensity of the Xaa-Pro-Tyr motif, with Gly, Pro, and Ala at position Xaa giving the greatest enhancement of the cis-peptidyl-prolyl population. We also show that CH···π interaction between Xaa and Tyr is responsible for the enhanced cis population. However, the mere presence of the CH···π interaction does not guarantee that the peptidyl-prolyl bond will have a higher cis content in Xaa-Pro-Tyr than in Xaa-Pro-Ala. Xaa-dependent intramolecular interactions present in Xaa-trans-Pro-Tyr can nullify favorable CH···π interactions in Xaa-cis-Pro-Tyr. The relative cis-peptidyl-prolyl stabilizing propensities of Xaa (Xaa-Pro-Tyr) in proteins and in our peptide series show strong linear correlation except when Xaa is aromatic. We also explore the Xaa-Pro-Gly-Tyr sequence motif and show that mediated by a Pro-Tyr CH···π interaction, the cis-peptidyl-prolyl bond in the motif is stabilized when Xaa is Pro.
ChemInform Abstract: Similarity Searching in REACCS. A New Tool for the Synthetic Chemist. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Investigation of a New Anion Exchange Membrane‐based Direct Ammonia Fuel Cell System (2018)

Abstract In this study, a direct ammonia fuel cell comprising of an anion exchange membrane‐based electrolyte is developed, built and tested in the laboratory for investigating the performance electrochemically. In this regard, the aqueous ammonia is used as a storage medium for unreacted fuel. With gaseous ammonia fuel, an open circuit voltage (OCV) of 280 ± 8 mV is obtained at an operating temperature of 25 °C and a pressure of 100 kPa (1 bar). Furthermore, the peak power density at ambient conditions with gaseous ammonia fuel is observed to be 6.4 ± 0.3 W m −2 . The unreacted gaseous fuel is stored in the form of aqueous ammonia and the fuel cell performance is tested at varying storage reservoir temperatures between 25 °C and 65 °C. An OCV of 110 ± 3 mV and a peak power density of 0.72 W m −2 is observed at an aqueous fuel temperature of 25 °C. Increasing storage reservoir and humidifier temperatures are found to improve the fuel cell performance characteristics.
Optimization of Fermentation Conditions for the Production of Legionaminic Acid in Recombinant Escherichia Coli (2017)

Legionaminic acid (Leg5,7Ac2) is a nonulosonic acid similar to sialic acid (Neu5Ac), which can be found in the extracellular glycoconjugates of several bacterial pathogens. Due to the similarity in stereochemistry of the two compounds, legionaminic acid has great potential in the production of pharmaceutical drugs. A novel biosynthetic pathway to produce legionaminic acid was created to overcome the limitations of organic synthesis. This is the first study involving the scale-up of legionaminic acid production by high cell density fermentation processes. In this work, fed-batch cultivations of recombinant Escherichia coli BRL04 were carried out in shake flasks and 5-L bioreactors. The final process was optimized by determining the effects of different carbon sources, induction temperatures, pH, dissolved oxygen (DO) content, induction optical density and N-acetylglucosamine (GlcNAc) feed rate on the production of legionaminic acid. Overall, results showed that the titer, yield and productivity for legionaminic acid production achieved relatively high levels, which were 5.53 g/L, 73.29% and 0.092 g/(Lh), respectively. It is hoped that this study accelerates research into the production of legionaminic acid for therapeutic treatments as well as for further study in glycobiology.
Intramural Research Internship: A Requirement Of The Undergraduate Bioengineering Curriculum At The University Of Pittsburgh (2020)

The primary goal of the Mechanobiology Laboratory is to understand the complex interactions between mechanical stimuli/forces and cellular behavior, along with utilizing molecular and cellular therapies, to enhance ligament healing.
Syntax and Semantics of Dependent Types (1997)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Study of software reliability prediction based on GR neural network (2011)

The failures of safety-critical software may result in the serious loss of property and life, thus software reliability has become very demanding. As an important quantitative approach for estimating and predicting software reliability, software reliability prediction technique is significantly useful for improving and ensuring software quality and testing efficiency. A novel software reliability prediction method based on general regression neural network (GRNN) is proposed, which makes it feasible that without constructing a statistical model like classic software reliability models and having difficulties of solving multivariate likelihood equations, this method can be used to predict software failures. It also incorporates test coverage which has increased prediction accuracy. By using probability plot technique and the least square fitting, the probability distribution functions of the original failure data can be determined. And large amount of data can be simulated to make the reliable prediction, which provides a way for solving the inaccuracy problem caused by small size sample of test failure data. A case study has also been done in a real failure data set. The results show that the proposed method can reflect the relationships among the time, test coverage and number of the faults. And it can improve the prediction accuracy.
Substrate Engineering of Inductors on SOI for Improvement of Q-Factor and Application in LNA (2020)

High Q-factor inductors are critical in designing high performance RF/microwave circuits on SOI technology. Substrate losses is a key limiting factor when designing inductors with high Q-factors. In this context, we report a substrate engineering method that enables improvement of quality factors of already fabricated inductors on SOI. A novel femtosecond laser milling process is utilized for the fabrication of locally suspended membranes of inductors with handler silicon completely etched. Such flexible membranes suspended freely on the BOX show up to 92 % improvement in Q-factor for single turn inductor. The improvement in Q-factor is reported on large sized inductors due to reduced parallel capacitance which allows enhanced operation of inductors at high frequencies. A compact model extraction methodology has been developed to model inductor membranes. These membranes have been utilized for the improvement of noise performance of LNA working in the 4.9 - 5.9 GHz range. A 0.1 dB improvement in noise figure has been reported by taking an existing design and suspending the input side inductors of the LNA circuit. The substrate engineering method reported in this work is not only applicable to inductors but also to active circuits, making it a powerful tool for enhancement of RF devices.
Indoor Intelligent Vehicle localization using WiFi received signal strength indicator (2017)

Success of Intelligent Vehicle navigation largely depends on the ability to localize precisely the vehicle in the environment. In general, all intelligent vehicle seemed to agree on a combination of non-cumulative error localization method like GPS with more precise localization method but suffered from cumulative errors like Laser-SLAM with an odometer. However, as GPS is only available for outdoor environment and since the indoor environment is also an important scenario for intelligent vehicles, a replacement of GPS for indoor localization is required. Successfully replacing GPS will not only provide a reliable indoor localization method for vehicles but also keep the architecture of vehicle localizing system consistent and achieve a smooth transition from outdoor to indoor and vice versa. Often, movement speed for indoor vehicles will be as low as 10–12km/h [1] but still, it surpasses the movement speed of human walking (3–5km/h) and presents a challenge for a tight and complex environment. This paper proposes an improved WiFi-fingerprinting method to replace GPS behavior for the indoor environment. The key contribution is to use a raw data smoothing technique with an ensemble classification neural network method to deal with noisy WiFi signal strength. Also, environment constraints are applied to improve localization result. Experiments show this method is capable of replacing GPS for the indoor environment.
Sphingoid Bases and Ceramide Induce Apoptosis in HT-29 and HCT-116 Human Colon Cancer Cells (2002)

Complex dietary sphingolipids such as sphingomyelin and glycosphingolipids have been reported to inhibit development of colon cancer. This protective role may be the result of turnover to bioactive metabolites including sphingoid bases (sphingosine and sphinganine) and ceramide, which inhibit proliferation and stimulate apoptosis. The purpose of the present study was to investigate the effects of sphingoid bases and ceramides on the growth, death, and cell cycle of HT-29 and HCT-116 human colon cancer cells. The importance of the 4,5-trans double bond present in both sphingosine and C(2)-ceramide (a short chain analog of ceramide) was evaluated by comparing the effects of these lipids with those of sphinganine and C(2)-dihydroceramide (a short chain analog of dihydroceramide), which lack this structural feature. Sphingosine, sphinganine, and C(2)-ceramide inhibited growth and caused death of colon cancer cells in time- and concentration-dependent manners, whereas C(2)-dihydroceramide had no effect. These findings suggest that the 4,5-trans double bond is necessary for the inhibitory effects of C(2)-ceramide, but not for sphingoid bases. Evaluation of cellular morphology via fluorescence microscopy and quantitation of fragmented low-molecular weight DNA using the diphenylamine assay demonstrated that sphingoid bases and C(2)-ceramide cause chromatin and nuclear condensation as well as fragmentation of DNA, suggesting these lipids kill colon cancer cells by inducing apoptosis. Flow cytometric analyses confirmed that sphingoid bases and C(2)-ceramide increased the number of cells in the A(0) peak indicative of apoptosis and demonstrated that sphingoid bases arrest the cell cycle at G(2)/M phase and cause accumulation in the S phase. These findings establish that sphingoid bases and ceramide induce apoptosis in colon cancer cells and implicate them as potential mediators of the protective role of more complex dietary sphingolipids in colon carcinogenesis.
Effect of electrical stimulation of the LES on LES pressure in a canine model (2008)

Gastric electrical stimulation modulates lower esophageal sphincter pressure (LESP). High-frequency neural stimulation (NES) can induce gut smooth muscle contractions. To determine whether lower esophageal sphincter (LES) electrical stimulation (ES) can affect LESP, bipolar electrodes were implanted in the LES of four dogs. Esophageal manometry during sham or ES was performed randomly on separate days. Four stimuli were used: 1) low-frequency: 350-ms pulses at 6 cycles/min; 2) high-frequency-1: 1-ms pulses at 50 Hz; 3) high-frequency-2: 1-ms pulses at 20 Hz; and 4) NES: 20-ms bipolar pulses at 50 Hz. Recordings were obtained postprandially. Tests consisted of three 20-min periods: baseline, stimulation/sham, and poststimulation. The effect of NES was tested under anesthesia and following IV administration of l-NAME and atropine. Area under the curve (AUC) and LESP were compared among the three periods, by ANOVA and t-test, P < 0.05. Data are shown as means +/- SD. We found that low-frequency stimulation caused a sustained increase in LESP: 32.1 +/- 12.9 (prestimulation) vs. 43.2 +/- 18.0 (stimulation) vs. 50.1 +/- 23.8 (poststimulation), P < 0.05. AUC significantly increased during and after stimulation. There were no significant changes with other types of ES. With NES, LESP initially rose and then decreased below baseline (LES relaxation). During NES, N(G)-nitro-l-arginine methyl ester increased both resting LESP and the initial rise in LESP and markedly diminished the relaxation. Atropine lowered resting LESP and abolished the initial rise in LESP. In conclusion, low frequency ES of the LES increases LESP in conscious dogs. NES has dual effect on LESP: an initial stimulation, cholinergically mediated, followed by relaxation mediated by nitric oxide.
MicroRNAs in neural cell development and brain diseases (2011)

MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.