gebhart/patrepeval huggingface dataset:
ELONGATION OF THE VASCULAR PEDICLE OF THE FREE JEJUNAL GRAFT (2000)

頭頸部癌切除後の口腔, 咽頭の再建には合併症の少なさや, その安全性から遊離空腸移植がよく用いられている。その際に根本的頸部郭清術が施行された場合, また粘膜欠損が頭側に及んでいる場合などでは, 血管柄の長さの不足を経験する事がある。このような場合に遊離空腸の辺縁動静脈を利用して血管柄を延長する方法を工夫したので報告した。まず遊離空腸移植の際の monitoring flap に対して血管柄の延長を2例に試み, 良好な血流が得られることを確認した。そして, 51歳女性の中咽頭癌切除後の欠損に対し血管柄を延長した遊離空腸パッチグラフトによる再建を行い良好な結果を得た。辺縁動静脈を利用することにより血管柄を約5cm延長することが可能であった。本法は口腔粘膜再建や下咽頭癌の上方進展例, また根本的頸部郭清術後で頸部の移植床血管がない場合など, 遊離空腸の血管柄から移植床血管までの距離が長い場合に有用な方法と考えられた。
Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis (2019)

Our study demonstrates that the coumarin derivative TCH-5c exerts its anti-cancer effects by 1. inhibiting endothelial cell proliferation, migration. 2. suppressing tube formation and angiogenesis induced by breast cancer cells in vitro and in vivo. Our results have potential implications in developing new approaches against breast cancer.
Lung Injury After Hepatoenteric Ischemia-Reperfusion: Role of Xanthine Oxidase (1996)

Oxidant stress plays a major role in the pathophysiologic processes associated with ischemia-reperfusion injury. Xanthine oxidase (XO) is often implicated as a significant source of oxidants and increases in the circulation after hepatoenteric ischemia-reperfusion. We hypothesized that pulmonary injury is associated with hepatic ischemia-reperfusion resulting from descending thoracic aorta occlusion-reperfusion (AoOR). We also proposed that this remote pulmonary injury is attenuated through inactivation of circulating and tissue XO by tungstate, implicating an XO-dependent mechanism. Aortic occlusion was established in rabbits (standard or tungstate diet) for 40 min by 2 h reperfusion. Sham operated rabbits (standard or tungstate diet) served as controls. Hepatic reperfusion injury, as manifested by release of the hepatocellular enzyme alanine aminotransferase (ALT), was markedly increased after AoOR. Suprarenal-infrahepatic occlusion failed to increase ALT release. Tungstate pretreatment significantly (p < 0.05) reduced XO activity and ameliorated liver and intestinal injury (p < 0.05). Lung injury, manifested by increased bronchoalveolar lavage (BAL) protein concentration, BAL lactate dehydrogenase (LDH) activity and increased lung edema was significantly associated with liver injury (p < 0.05) and circulating XO activity (p < 0.001). XO inactivation significantly decreased BAL protein concentration, BAL LDH activity, and lung edema (p < 0.05). We conclude that remote pulmonary injury is significantly influenced by the extent of liver injury and circulating XO activity.
Actions of Tumor Necrosis Factor on Cultured Vascular Endothelial Cells: Morphologic Modulation, Growth Inhibition, and Cytotoxicity (1986)

Exposure to highly purified preparations of murine tumor necrosis factor (TNF) resulted in distinct morphologic changes and proliferation inhibition of cultured endothelial cells from the bovine aorta and capillary and of those from the human umbilical vein. The TNF preparation also inhibited the proliferation of bovine aortic smooth muscle cells but failed to inhibit the proliferation of bovine and human fibroblasts. The cytotoxic activity of the TNF preparation was prominent only in bovine capillary endothelial cells. Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (PAGE), and upon PAGE only, of the TNF preparations, the fractions representing growth inhibitory and cytotoxic activities against bovine capillary endothelial cells exactly corresponded to those containing migrated TNF. Treatments of the TNF preparations with heat and polymyxin B revealed that the effects on endothelial cells were not due to possibly contaminated endotoxin. Moreover, growth inhibitory and cytotoxic actions of rabbit TNF on bovine capillary endothelial cells were completely neutralized by the addition of an anti-rabbit TNF monoclonal antibody. These results suggest that TNF causes morphologic changes in, growth inhibition of, and cytotoxicity against, the vascular endothelial cells.
Cortical stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury (2023)

Neural activity and learning lead to myelin sheath plasticity in the intact central nervous system (CNS), but this plasticity has not been well-studied after CNS injury. In the context of spinal cord injury (SCI), demyelination occurs at the lesion site and natural remyelination of surviving axons can take months. To determine if neural activity modulates myelin and axon plasticity in the injured, adult CNS, we electrically stimulated the contralesional motor cortex at 10 Hz to drive neural activity in the corticospinal tract of rats with sub-chronic spinal contusion injuries. We quantified myelin and axonal characteristics by tracing corticospinal axons rostral to and at the lesion epicenter and identifying nodes of Ranvier by immunohistochemistry. Three weeks of daily stimulation induced very short myelin sheaths, axon branching, and thinner axons outside of the lesion zone, where remodeling has not previously been reported. Surprisingly, remodeling was particularly robust rostral to the injury which suggests that electrical stimulation can promote white matter plasticity even in areas not directly demyelinated by the contusion. Stimulation did not alter myelin or axons at the lesion site, which suggests that neuronal activity does not contribute to myelin remodeling near the injury in the sub-chronic period. These data are the first to demonstrate wide-scale remodeling of nodal and myelin structures of a mature, long-tract motor pathway in response to electrical stimulation. This finding suggests that neuromodulation promotes white matter plasticity in intact regions of pathways after injury and raises intriguing questions regarding the interplay between axonal and myelin plasticity.
Noncentrosymmetric Columnar Liquid Crystals with the Bulk Photovoltaic Effect for Organic Photodetectors (2020)

The bulk photovoltaic effect (BPVE) has drawn intensive attention due to its unique features that cannot be accessed with the conventional photovoltaic effect. However, the BPVE is observed in noncentrosymmetric materials and has been studied mainly for inorganic materials. Here, we report a simple subphthalocyanine (SubPc) derivative that assembles into a noncentrosymmetric columnar liquid crystal with the help of a DC E-field. These columnar assemblies exhibit the BPVE over a wide range of wavelengths up to 650 nm. Furthermore, just by sandwiching this columnar assembly between two ITO electrodes, the resultant device reaches a light-on/off ratio, <i>I</i><sub>light</sub>/<i>I</i><sub>dark</sub>, as high as 6.6 × 10<sup>3</sup>, indicating that the polar columnar assemblies with SubPcs are promising for photodetectors.
Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP‐1 signalling pathways (2006)

Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring polyphenolic phytoalexin found in grapes, and has been shown to inhibit the growth of various types of cancer cells. We investigated the mechanism of the antiproliferative effect of resveratrol in A431-transformed keratinocytes harbouring mutant p53, and show that it is accompanied by G1 cell cycle arrest, which coincides with a marked inhibition of G1 cell cycle regulatory proteins, including cyclins A and D1 and cyclin-dependent kinase (CDK)6 and p53-independent induction of p21WAF1. Cell cycle arrest was also associated with the accumulation of hypophosphorylated Rb and p27KIP1. Resveratrol inhibited mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)1 > extracellular signal-regulated protein kinase (ERK)1/2 signalling, downregulated c-Jun, and suppressed activating protein (AP)-1 DNA-binding and promoter activity. In addition, the inhibition of MEK1 > ERK1/2 signalling appears to be independent of retinoblastoma protein (pRb) hypophosphorylation in A431 cells, as PD098059 did not suppress pRb phosphorylation. Our results demonstrate that resveratrol affects multiple cellular targets in A431 cells, and that the downregulation of both AP-1 and pRb contributes to its antiproliferative activity in these cells.
A general approach to fast online training of modern datasets on real neuromorphic systems without backpropagation (2022)

We present parameter-multiplexed gradient descent (PMGD), a perturbative gradient descent framework designed to easily train emergent neuromorphic hardware platforms. We show its applicability to both analog and digital systems. We demonstrate how to use it to train networks with modern machine learning datasets, including Fashion-MNIST and CIFAR-10. Assuming realistic timescales and hardware parameters, our results indicate that PMGD could train a network on emerging hardware platforms orders of magnitude faster than the wall-clock time of training via backpropagation on a standard GPU/CPU.
Superconducting Oxide Thin Films Prepared by Sol–Gel Technique Using Metal Alkoxides (1988)

Abstract Superconducting oxide thin films of the YBa2Cu3Ox system have been prepared on zirconia (YSZ) substrates by sol–gel technique using metal alkoxide solution. Yttrium butoxide, barium methoxide and copper methoxide in a given atomic ratio were dissolved in a triethanolamine–methanol solution. Coating of the resultant solution, heating at 800 °C in air and annealing in an oxygen atmosphere resulted in superconducting oxide thin films. The onset of superconductivity was seen at 98 K and the resistance rapidly decreased with decreasing temperature, reaching substantially zero at 56 K.
Porous silicon oxynitrides formed by ammonia heat treatment (1990)

Porous silicon and its oxide can be converted into porous silicon oxynitrides by ammonia heat treatment. For example, ammonia treatment at 1000 °C for 1 h following 850 °C, 30-min steam oxidation of porous silicon can result in up to 40 at. % nitrogen in the porous oxynitrides. These porous silicon oxynitrides are compositionally more uniform than ammonia-nitrided thermal oxides which exhibit nitrogen buildup at the oxide layer interfaces. However, the order of the oxidation and nitridation treatment matters: nitrided oxidized porous silicon exhibits higher electrical breakdown strength than nitrided porous silicon or oxidized nitrided porous silicon.
Growth inhibition and induction of cellular differentiation of human myeloid leukemia cells in culture by carbamoyl congeners of ribavirin (1990)

A series of 1,2,3-triazole (2), pyrazole (3 and 5), and pyrrole (4) ribonucleosides with two adjacent carbamoyl groups have been synthesized and evaluated for cell growth inhibition and induction of cellular differentiation of HL-60 cells in culture. Glycosylation of the TMS derivatives of dimethyl 1,2,3-triazole-4,5-dicarboxylate (6) and diethyl pyrazole-3,4-dicarboxylate (7) with 1-O-acetyl-2,3,5-tri-O-benzoyl-D- ribofuranose (8) in the presence of TMS triflate gave predominantly the beta-nucleosides 9 and 14, respectively. Ammonolysis of 9 and 14 furnished 2-beta-D-ribofuranosyl-1,2,3-triazole-4,5-dicarboxamide (2) and 1-beta-D-ribofuranosylpyrazole-3,4-dicarboxamide (3), respectively. Stereoselective ring annulation of 1-deoxy-1-hydrazinyl-2,3-O-isopropylidene-D- ribose (16) with tetracyanoethylene (15) gave 5-amino-1-(2,3-O-isopropylidene-beta-D-ribofuranosyl)pyrazole-3,4- dicarbonitrile (17). Deisopropylidenation of 17, followed by oxidative hydrolysis of the reaction product (18), gave the 5-amino derivative of 3 (5). Stereospecific glycosylation of the sodium salt of preformed diethyl pyrrole-3,4-dicarboxylate (22) with 1-chloro-2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-alpha-D- ribofuranose (23) was accomplished to furnish blocked nucleoside 24, which on ammonolysis and deisopropylidenation gave 1-beta-D-ribofuranosylpyrrole-3,4-dicarboxamide (4). The structures of 2 and 3 were assigned by single-crystal X-ray diffraction studies, which showed extensive inter- and intramolecular hydrogen bonding. Nucleosides 2-5 are devoid of significant cytotoxic properties against L1210 and WI-L2 leukemia cells in culture. However, these compounds were found to be inducers of cellular differentiation of HL-60 cells in the range of 30-60 microM and were comparable to ribavirin in this regard.
Determination of the crustal structure in southern Tibet by dispersion and amplitude analysis of Rayleigh waves (1999)

Surface waves recorded by the nine broad-band stations of the INDEPTH II experiment are analysed to study the crustal structure of southern Tibet. Their frequency range is between approximately 0.015 and 0.050 Hz (i.e. between 20 and 60 s period). Phase velocity dispersion curves are calculated for the regions north and south of the Tsangpo suture, using Wiener ltering of fundamental mode Rayleigh waves incident upon the array with dierent backazimuths. The two dispersion curves are inverted to obtain the S-wave crustal models north and south of the suture. They show that a low-velocity layer is present in the lower crust north but not south of the Tsangpo suture. To conrm these ndings, variations in the amplitudes of the Rayleigh waves across the suture are interpreted by numerical simulation. The strong amplitude variations at a 30 s period are reproduced using a model with a low-velocity layer in the lower crust north of the suture, a normal high-velocity layer to the south, and a sharp transition between these layers.
An improved protocol for the preparation of yeast cells for transformation by electroporation (1998)

Pretreatment of yeast cells with lithium acetate (LiAc) and dithiothreitol (DTT) enhances the frequency of transformation by electroporation. The method shows improvements of 6-67-fold in wild-type strains derived from commonly used Saccharomyces cerevisiae genetic backgrounds. In addition, 15-300-fold improvement in transformation frequency was achieved with several mutant strains of S. cerevisiae that transformed poorly by conventional procedures. Both DTT and lithium acetate were necessary for maximal transformation frequencies. Pretreatment with lithium and DTT also resulted in an approximately 3-5-fold increase in the electroporation transformation frequency of the pathogenic fungus Candida albicans.
L-Tetrolet Pattern-Based Sleep Stage Classification Model Using Balanced EEG Datasets (2022)

The recommended L-tetrolet pattern and TSRFINCA-based model push the envelope of current knowledge engineering by accurately classifying sleep stages even in the presence of sleep disorders.
Significance of MMP-2 expression in prostate cancer: an immunohistochemical study. (2003)

Prostate cancer is the most common cancer in North American men. Currently available prognostic factors inadequately predict which cancers will be aggressive and which will lead an indolent course. This study was aimed at investigating the role of matrix metalloproteinase (MMP)-2 in prostate cancer disease-free survival. We correlated MMP-2 expression by malignant prostatic epithelium and stromal cells with prostate cancer disease-free survival in 187 stage pT3NxM0 prostate carcinomas using immunohistochemistry. MMP-2 was expressed by cancer cells in 131 cases (70.0%) and by stromal cells in 142 cases (75.9%). MMP-2 expression by stromal cells was not associated with progression (P = 0.7270). However, in multivariate analyses, adjusting for the Gleason score, tumor-node-metastasis stage, and initial serum prostate-specific antigen, MMP-2 expression by >50% of malignant epithelial cells was associated with decreased disease-free survival (hazard ratio, 4.267; P = 0.0012). Increased MMP-2 expression by malignant prostatic epithelia is an independent predictor of decreased prostate cancer disease-free survival.
A Decreased Ratio of Laminin-332 β3 to γ2 Subunit mRNA is Associated with Poor Prognosis in Colon Cancer (2009)

Laminin-332 (Ln-332) is a heterotrimeric glycoprotein (alpha3beta3gamma2) unique to epithelial cells with crucial roles in signaling, adhesion, and migration. Altered localization or expression levels of Ln-332, particularly its gamma2 subunit, are of prognostic value in a variety of cancers. However, the lack of standardized methodology and the limited quantification of previous study results have left unanswered questions, including the role of gamma2 transcript variants and whether differential expression of this chain represents dysregulation of the whole heterotrimer. Herein, we test the hypothesis that mRNA changes in one or more Ln-332 encoding genes can be used to distinguish between early- and advanced-stage cancer specimens and shed light on mechanistic questions raised by previous studies. Statistical analyses of human microarray data from the publicly available expression project in Oncology (expO) dataset, including examination of the distributions of Ln-332 subunit mRNA levels, identified a significant decrease in the Ln-332 beta3:gamma2 mRNA ratio between normal (n = 10) and early-stage colon cancer (n = 29) specimens. The beta3:gamma2 ratio was further decreased in metastatic colon cancer (n = 41) compared with early-stage samples. Our findings raise the possibility that Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. Further, standardized, quantitative methods for patient prognosis and therapeutic choice could be developed based upon the Ln-332 mRNA changes we uncovered.
Accidental Radiogenic Ulcer of the Fingers in an Industrial Setting (2002)

The incidence of accidental radiogenic damage to the skin is low. We report a case of delayed ulcerative contact radiodermatitis following accidental industrial exposure. Recurrent ulcerations of the fingers were treated successfully by flap surgical reconstruction.
Lessons Learned from Project SMART (2011)

In the project SMART (Strategies to proMote small scAle hydro electRicity producTion in Europe) from the programme IEE (Intelligent Energy Europe) 7 institutions from 5 European states participate: Province of Cremona – Italy ; CESI RICERCA SPA – Italy ; Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb – Croatia ; Karlovac County – Croatia ; Norwegian University of Science and Technology – Norway ; Regional Secretariat of Attica - Greece and Energieagentur Waldviertel – Austria. The SMART proposal address to important barriers for the expansion of small-scale hydro electricity production in Europe: the lack of suitable support methodologies and tools able to create a clear view of the mini-hydro potential in the territory, the complexity of the legal/administrative processes to obtain concessions, the economical/financial attraction of private investors. Main objective of project is to give clear contributions to pull down these non-technological barriers, as helpful tools for European, national, regional and local authority decision-makers for increasing the implementation of small-scale hydro electricity plants (SHP). Policies, methodologies and tools to improve water resources management, to better communicate, disseminate opportunities to investors, and to increase the interest of stakeholders to invest in small scale electric plant are defined. 5 representative regions in the partner countries serve as learning areas about strategic actions. In previous papers, the results of investigations performed with aim to detection and pull down the non-technological legal/administrative barriers in partner states are presented. Now, lessons (strategic action) learned from pilot regions, which contribute to wider implementation and technical viability of SHP will be presented: hydrological data review and modelling is one of the most important parameters in determining the feasibility of a site ; topographic and geological data review ; the hydropower assessment must include selection and optimisation of the operating range of the turbine and the capacity factor of the scheme ; social and environmental impact assessment must be made, including consideration of land acquisition ; preliminary design and scheme arrangements need to be made ; costing should be assessed with necessary accuracy and contingency ; appropriate technology – ensure that the technology is appropriate to the location ; selection criteria developed should consider the technical feasibility, etc. Previously will be elaborated and illustrated on the locations for SHP in pilot region Karlovac County (Croatia) using the original software developed by the project partners.
FOODS OF ANIMAL ORIGIN (1943)

NATURAL AND ECONOMIC RELATIONSHIPS Grouped according to natural relationships and then arranged in descending order of economic prominence, the chief types of food of animal origin are as follows: Meats, including fish and poultry, which together command about one fourth 1 of the average American expenditure for food. Milk in its various forms, including cheese, cream and ice cream, representing usually one tenth to one-eighth of the food budget. Butter and other animal fats, about one tenth. Eggs, about one twentieth. Shellfish, which occupy but a small place in the nation's food budget but lend interest to variations in the dietary. While this sketch will be systematized largely in terms of this fivefold grouping of its subject matter, it will also be possible to avoid repetition by arranging the discussion according to successive aspects of nutritive value. PHYSICAL STRUCTURE, PROXIMATE COMPOSITION, PROTEIN AND ENERGY VALUES IN NUTRITION Meats, Poultry and Fish
Effects of addition of condensed tannin on the structure and properties of silk fibroin film (2016)

Abstract Condensed tannin is a polymeric polyphenol compound, which has considerable protein‐binding ability and a variety of bioactivities, such as anti‐inflammatory, antithrombotic and antimicrobial activities. In this study, silk fibroin film was modified by adding condensed tannin. It was found that strong intermolecular interactions occurred between silk fibroin and tannin, and incorporation of 1–10% (w/w) tannin in the blend films resulted in more compact, stiffer but less elastic films. Swelling and dissolution trials showed that the addition of tannin significantly reduced the swelling and solubility of the films. The mechanical properties, swelling and solubility of the blend films varied as a function of tannin concentration, showing optimum values when containing 10% (w/w) tannin. The silk fibroin–tannin films all showed significant antioxidant activity and antibacterial activity against Gram‐positive bacteria, and the activities were positively related to the concentration of tannin. The results emphasized that the addition of condensed tannin could simultaneously improve the structural stability of silk fibroin film and impart functional properties. © 2016 Society of Chemical Industry