gebhart/patrepeval huggingface dataset:
Antimicrobial Effect of Cinnamon Essential Oil Against Escherichia Coli and Staphylococcus aureus (2015)

Background: Various studies have been conducted to determine the effects of essential oils and other natural antimicrobials on foodborne pathogens in culture media. Objectives: The present study aimed to determine the antibacterial effects of cinnamon essential oil, monolaurin, nisin, and ethylenediaminetetraacetic acid (EDTA) alone and in combination, in culture media. Materials and Methods: Cinnamon essential oil was analyzed by gas chromatography/mass spectrometry (GC/MS) and the major component was identified as cinnamaldehyde. Broth microdilution assay and agar disk diffusion method were used to evaluate the antibacterial effect of cinnamon essential oil, monolaurin, nisin, and EDTA alone and in combination against Staphylococcus aureus and Escherichia coli. Results: The MIC of cinnamon essential oil, monolaurin, nisin, and EDTA for S. aureus was 3125.00, > 500.00, > 125.00, and > 250.00 Âµg/mL, respectively, while the MIC of the aforementioned materials for E. coli was 780.00, 31.25, 15.60, and 250.00 Âµg/mL. In the present study, S. aureus was found to be more sensitive than E. coli and monolaurin and nisin showed the lowest MIC for E. coli. Increased antimicrobial effect was observed when cinnamon essential oil was used in combination with nisin, monolaurin, and EDTA. Conclusions: The present study showed that cinnamon essential oil when used in combination with nisin, monolaurin or EDTA demonstrated stronger antimicrobial effect against foodborne pathogens than when used alone.
Broadband Spectral Reflectance Models of Turfgrass Species and Cultivars to Drought Stress (2007)

The objective of this study was to assess canopy broadband spectral reflectance for turfgrasses under drought stress. Optimum turf quality (TQ) and leaf firing (LF) models were developed and compared based on two, three, and five wavelength bands. Sods of bermudagrass ( Cynodon dactylon L. × C. transvaalensis Burtt‐Davy), seashore paspalum ( Paspalum vaginatum Swartz), zoysiagrass ( Zoysia japonica Steud.), and St. Augustinegrass [ Stenotaphrum secundatum (Walt.) Kuntze], and seeded tall fescue ( Festuca arundinacea Schreb.) were used in this study with three cultivars each of bermudagrass, seashore paspalum, and tall fescue. Traditional vegetation indices (VIs) based on two bands within 660 to 950 nm were not as sensitive as three to five broadband models using a wider band range of 660 to 1480 nm. Optimum models were cultivar specific models, even within a species. The broadband wavelength at R900 and R1200 should be considered in drought sensitive spectral models since they were most often observed and exhibited high partial R 2 values. These results suggest that mobile broadband spectral devices to map turfgrass responses to drought stress would benefit by the availability of three to five broadbands that could be user selected for optimum, cultivar specific models.
Wirkungspotenziale von Adaptive Cruise Control und Lane Guard System bei schweren Nutzfahrzeugen. Teile 1 und 2 (2006)

Im Rahmen des Projektes Safe Truck wurden die Wirksamkeit der schon in Serie verfuegbaren Helfer Adaptive Cruise Control (ACC) (abstandsgeregelter Tempomat) und Lane Guard System (LGS) (Spurverlassenswarner) durch das Allianz Zentrum fuer Technik untersucht. Im Beitrag wird auf die Gruende der Untersuchung, die Vorgehensweise bei der Untersuchungsmethode sowie die Funktionsbeschreibung der oben genannten elektronischen Fahrhilfen beim Lkw eingegangen. Die Struktur der Lkw-Unfaelle hinsichtlich ACC-Relevanz und LGS-Relevanz werden beschrieben. Abschliessend wird auf die Unfallvermeidbarkeit bei beiden Systemen eingegangen. Dabei wird unter anderem festgehalten, dass die Realisierung der Unfallvermeidbarkeit sowie des damit verbundenen Nutzens voraussetzt, dass das jeweilige System vom Fahrer verantwortungsvoll genutzt wird und im Fahrbetrieb eingeschaltet ist.
1542 Gbps Fully Pipelined Fast-SSC Decoding of Polar Codes (2022)

Polar codes are one of the candidates as a Forward-Error Correction (FEC) scheme for next-generation high-throughput communication systems. Successive Cancellation (SC) is one of the main decoding algorithms for decoding polar codes. In this paper, a fully pipelined fast Simplified SC (SSC) decoding architecture is proposed which proves a throughput of 1542 Gb/s in a 28 nm CMOS ASIC technology. This architecture is fully pipelined in the sense that sequences are decoded successively in consecutive clock cycles. The implementation results after the design Place&Route show improvements in terms of decoding throughput, clock frequency, core area, and energy efficiency compared with the state-of-the-art.
Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer. (2003)

In Israeli prostate cancer patients, the EPHX His113 allele is seemingly associated with a more advanced, late-onset disease. These preliminary data need to be confirmed by a larger and more ethnically diverse study.
Data from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and correlated with survival time of the patient. Microarray analysis was conducted on MiaPaCa2 cells subjected to metabolic stress in Nupr1-silenced conditions. DNA repair and cell cycle–associated gene expression was confirmed by real-time quantitative PCR (qRT-PCR). Nupr1 and AURKA protective role were analyzed using RNA interference (RNAi) silencing or overexpression. DNA damage and autophagy were analyzed by Western blot analysis and immunofluorescence.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We showed that both Nupr1 and HIF1α are coexpressed in human pancreatic ductal adenocarcinoma (PDAC) samples and negatively correlate with survival time. PDAC-derived cells submitted to hypoxia and/or glucose starvation induce DNA damage–dependent cell death concomitantly to the overexpression of stress protein Nupr1. Affymetrix-based transcriptoma analysis reveals that Nupr1 knockdown enhances DNA damage and alters the expression of several genes involved in DNA repair and cell-cycle progression. Expression of some of these genes is common to hypoxia and glucose starvation, such as &lt;i&gt;Aurka&lt;/i&gt; gene, suggesting that Nupr1 overexpression counteracts the transcriptional changes occurring under metabolic stress. The molecular mechanism by which hypoxia and glucose starvation induce cell death involves autophagy-associated, but not caspase-dependent, cell death. Finally, we have found that &lt;i&gt;AURKA&lt;/i&gt; expression is partially regulated by Nupr1 and plays a major role in this response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our data reveal that Nupr1 is involved in a defense mechanism that promotes pancreatic cancer cell survival when exposed to metabolic stress. &lt;i&gt;Clin Cancer Res; 18(19); 5234–46. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Hard Template Synthesis of Mesoporous Hydroxyapatite Materials for Controlled Protein Release (2010)

This chapter contains sections titled: Introduction Synthesis and Characterizations Results and Discussion Conclusion
High BCR-ABL/GUSIS Levels at Diagnosis Are Associated with Unfavorable Responses to Standard Dose Imatinib (2015)

Abstract Background The approval of second-generation tyrosine kinase inhibitors (TKIs) for the first line treatment of Chronic Myeloid Leukemia (CML) has generated a need for early molecular parameters associated with inadequate responses to Imatinib Mesylate (IM). Objective We correlated quantitative determination of BCR-ABL transcripts at diagnosis with the outcome (defined according to the 2013 European Leukemia Net recommendations) of 272 newly diagnosed CML patients receiving IM 400 mg/die. Methods BCR-ABL transcripts were measured from peripheral blood samples drawn at diagnosis before patients received any pharmacological treatment using Real-Time Quantitative PCR (RQ-PCR). All molecular determinations were performed twice (in triplicates) on the same sample using either ABL or glucuronidase-beta (GUS) as reference genes. BCR-ABL values were then reported on the international scale (IS). Results With a median follow-up of 60 months, 65.4% of patients achieved an optimal response, 5.6% presented a response currently defined as "warning", 22.4% failed IM treatment and 6.6% switched to a different tyrosine kinase inhibitor because of intolerance to the drug. We recorded 19 deaths (6.9%), 7 (2.5%) attributable to disease progression. We applied Receiver Operating Characteristic (ROC) curves to define BCR-ABL/GUSIS expression levels that would separate patients likely (i.e. below the threshold) or unlikely (i.e. above the threshold) to achieve multiple endpoints, namely: optimal response (OR), failure-free survival (FFS), event-free survival (EFS), transformation-free survival (TFS) and overall survival (OS). Employing the specific threshold calculated for each endpoint we found that high BCR-ABL/GUSIS levels at diagnosis were associated with inferior probabilities of OR (p&lt;0.001), FFS (p&lt;0.001) and EFS (p&lt;0.001). Elevated BCR-ABL/GUSIS levels were also associated with higher rates of disease transformation to the accelerated phase or blast crisis (p=0.029) but not with OS (p=0.132). Conclusions High BCR-ABL transcripts at diagnosis measured by RQ-PCR employing GUS as a reference gene allow the identification of CML patients unlikely to benefit from standard dose IM that should be considered for alternative forms of treatment. Disclosures Hochhaus: Novartis: Honoraria, Research Funding; Bristol-Myers Squibb: Honoraria, Research Funding; ARIAD: Honoraria, Research Funding; Pfizer: Honoraria, Research Funding.
399 Cosibelimab, an anti-PD-L1 antibody: preliminary safety and efficacy results from a global, multicohort phase 1 clinical trial (2020)

<h3>Background</h3> Cosibelimab is a high affinity, fully-human IgG1 monoclonal antibody that directly binds to programmed death ligand-1 (PD-L1) and blocks its interaction with the programmed death receptor-1 (PD-1) and B7.1 receptors to restore an anti-tumor immune response. Cosibelimab has the additional benefit of a functional Fc domain capable of inducing antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against tumor cells. Study CK-301–101 is a global, multicenter, multicohort trial that is enrolling patients (pts) with select advanced cancers, including pivotal cohorts of pts with metastatic and locally advanced cutaneous squamous cell carcinoma (cSCC) and a cohort of pts with previously untreated advanced non-small cell lung cancer (NSCLC). <h3>Methods</h3> Eligible pts were aged ≥18 years with an Eastern Cooperative Oncology Group performance status of 0–1. The cSCC cohorts enrolled pts with histologically confirmed metastatic or locally advanced cSCC not amenable to local therapy. The NSCLC cohort enrolled previously untreated NSCLC pts with advanced disease and a PD-L1 tumor proportion score of at least 50%. Pts received a fixed dose of 800 mg cosibelimab administered intravenously every two weeks. Anti-tumor activity was assessed by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 and were conducted every 8 weeks for the initial 32 weeks on study, and every 12 weeks thereafter. <h3>Results</h3> As of August 2020, 114 pts (73M/41F, median age 66 years) with diverse tumor types have been enrolled and treated with cosibelimab. Among these pts, 103 (90%) experienced ≥1 treatment-emergent adverse event (AE), 42 (37%) experienced a grade ≥3 AE, and 6 (5%) experienced a grade ≥3 drug-related AE. The most common AEs were fatigue (25%), anemia (21%), rash (18%) and nausea (16%) and the most common drug-related AEs were fatigue (15%) and rash (14%). In 42 cSCC pts evaluable for response, ORR based on investigator assessment of tumor response was 55% (95% confidence interval [CI]: 39, 70), including 5 (12%) complete responses, with 20/23 (87%) responses ongoing and 10 responses ≥6 months in duration as of data cutoff. In 25 NSCLC pts evaluable for response, ORR based on investigator assessment was 44% (95% CI: 24, 65), with 5/11 (45%) responses ongoing and 10 responses ≥6 months in duration. <h3>Conclusions</h3> Cosibelimab has a predictable and manageable safety profile and demonstrated robust clinical activity in cSCC and NSCLC pts, including durable complete and partial responses. Updated results will be presented. <h3>Trial Registration</h3> NCT03212404 <h3>Ethics Approval</h3> The study was approved by an appropriate ethics committee for each participating institution. Informed consent was obtained for all subjects. <h3>Consent</h3> Written informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
The denaturing effectiveness of guanidinium, carbamoylguanidinium, and guanylguanidinium salts (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe denaturing effectiveness of guanidinium, carbamoylguanidinium, and guanylguanidinium saltsF. J. Castellino and Robert. BarkerCite this: Biochemistry 1968, 7, 11, 4135–4138Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/bi00851a049https://doi.org/10.1021/bi00851a049research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combining Enabling Techniques in Organic Synthesis: Solid Phase Assisted Catalysis under Microwave Conditions Using a Stable Pd(II)‐Precatalyst. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Advanced lung adenocarcinoma patient with EGFR exon 20 insertion benefits from high-dose furmonertinib for nine months after progression from mobocertinib: a case report (2022)

Supported by this case and data from other studies, the potency of furmonertinib warrants further evaluation in patients with <i>EGFR</i> 20ins, especially those pretreated with TKIs.
The effect of contingent music to increase non-nutritive sucking of premature infants. (2002)

This study assessed music as reinforcement for non-nutritive sucking of 12 premature infants born at an average gestation of 29.3 weeks and an average birthweight of 1111.9 g. At the time of the study, the infants' average post conception age was 35.5 weeks, and their average weight was 1747.3 g. A pacifier was fitted with a pressure transducer so that a sufficient suck activated frequency and duration signals as well as 10 seconds of recorded music consisting of lullabies sung by female vocalists. A 14-minute ABAB study design included a silence baseline for 2 minutes, 5 minutes of contingent music, 2 minutes of silence, and 5 minutes of contingent music. Frequency data were recorded for each 5-second interval in which the duration light was activated for at least 3 seconds. Results demonstrated that sucking rates during the periods of contingent music were 2.43 times greater than baseline (silence) sucking rates. In this study, music contributed significantly to the development of non-nutritive sucking of premature infants.
Belief propagation based decoding of large non-orthogonal STBCs (2009)

In this paper, we present a belief propagation (BP) based algorithm for decoding non-orthogonal space-time block codes (STBC) from cyclic division algebras (CDA) having large dimensions. The proposed approach involves message passing on Markov random field (MRF) representation of the STBC MIMO system. Adoption of BP approach to decode non-orthogonal STBCs of large dimensions has not been reported so far. Our simulation results show that the proposed BP-based decoding achieves increasingly closer to SISO AWGN performance for increased number of dimensions. In addition, it also achieves near-capacity turbo coded BER performance; for e.g., with BP decoding of 24 × 24 STBC from CDA using BPSK (i.e., 576 real dimensions) and rate-1/2 turbo code (i.e., 12 bps/Hz spectral efficiency), coded BER performance close to within just about 2.5 dB from the theoretical MIMO capacity is achieved.
Scalable Interactive Visualization for Connectomics (2017)

Connectomics has recently begun to image brain tissue at nanometer resolution, which produces petabytes of data. This data must be aligned, labeled, proofread, and formed into graphs, and each step of this process requires visualization for human verification. As such, we present the BUTTERFLY middleware, a scalable platform that can handle massive data for interactive visualization in connectomics. Our platform outputs image and geometry data suitable for hardware-accelerated rendering, and abstracts low-level data wrangling to enable faster development of new visualizations. We demonstrate scalability and extendability with a series of open source Web-based applications for every step of the typical connectomics workflow: data management and storage, informative queries, 2D and 3D visualizations, interactive editing, and graph-based analysis. We report design choices for all developed applications and describe typical scenarios of isolated and combined use in everyday connectomics research. In addition, we measure and optimize rendering throughput—from storage to display—in quantitative experiments. Finally, we share insights, experiences, and recommendations for creating an open source data management and interactive visualization platform for connectomics.
An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment (2016)

This novel test is able to predict the clinical response to Ida+Ara-C induction with overall correlation and predictive values of 80%, higher than ever achieved. Considering this result and current clinical response&#13;\nrate of 66.7% (70% in this study), clear clinical benefits can be achieved with&#13;\nthe use of the test. Adding the cytogenetic risk profile further increase the correlation&#13;\nto 90%. Thus this novel test may be valuable information to guide 1st line patient therapy
Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study (2021)

Monotherapy with intravitreal sirolimus for subjects with persistent, exudative age-related macular degeneration appears to have a limited positive anatomic benefit. The presence of adverse events in the experimental group merits further evaluation, potentially as an adjuvant therapy. Trial registration This trial was registered with the clinicaltrials.gov, NCT02357342, and was approved by the institutional review board at Advarra. Funding was provided by an investigator-initiated grant from Santen. Santen played no role in the design or implementation of this study.
Abstract 29: Prepectoral Direct-to-Implant Breast Reconstruction: Safety Outcome Endpoints and Delineation of Risk Factors (2019)

PURPOSE: Immediate implant-based breast reconstruction is the leading technique for post-mastectomy reconstruction. Although implants are generally placed beneath the pectoralis major muscle, recent developments have allowed for implant placement above the muscle in a prepectoral plane. In fact, prepectoral breast reconstruction has been shown to mitigate complications associated with subpectoral breast reconstruction, including animation deformity and discomfort. Still, few studies have reported long term outcomes of prepectoral implant placement in the context of direct-to-implant (DTI) breast reconstruction. This study aimed to compare safety outcome endpoints between prepectoral and subpectoral DTI reconstruction. We hypothesized that prepectoral DTI breast reconstruction is a safe alternative to subpectoral DTI breast reconstruction. METHODS: Retrospective chart review at a tertiary academic medical institution identified 115 patients who underwent prepectoral DTI reconstruction and 142 patients who underwent subpectoral DTI reconstruction over a 5-year period. Univariate analysis was performed to compare patient characteristics between both cohorts. A penalized logistic regression identified relationships between postoperative complications and covariate variables in each group. RESULTS: A binomial regression model revealed that prepectoral DTI breast reconstruction is associated with lower risk of surgical site infection (p = 0.04) and lower risk of revision (p = 0.01) when compared to subpectoral DTI breast reconstruction. Rates of capsular contracture, explant, skin necrosis, and hematoma were comparable between groups. CONCLUSION: This study compared the safety outcomes and risk factors in prepectoral and subpectoral DTI reconstruction patient cohorts. These findings support the hypothesis that prepectoral DTI breast reconstruction is a safe alternative to subpectoral DTI breast reconstruction, where the analysis revealed that patients who underwent prepectoral DTI reconstruction experienced lower rates of surgical site infection. It is speculated that the significant difference in surgical site infection may be due to decreased procedure time of the prepectoral procedure, or decreased dissection with preservation of the pectoralis major muscle and vascular network. Prepectoral DTI patients also presented with significantly lower rates of revision when compared to subpectoral DTI patients. Ultimately, this study demonstrated that prepectoral DTI breast reconstruction has a favorable safety profile when compared to supbectoral DTI reconstruction. Prospective study of prepectoral DTI is in progress to collect patient reported outcomes to further delineate safety and efficacy of this breast reconstruction approach.