gebhart/patrepeval huggingface dataset:
cAMP-mediated differential regulation of lignin peroxidase and manganese-dependent peroxidase production in the white-rot basidiomycete Phanerochaete chrysosporium. (1992)

Lignin peroxidases (LIPs) and manganese-dependent peroxidases (MNPs) are major components of the lignin-degrading enzyme system of Phanerochaete chrysosporium and typically appear during secondary metabolism. The involvement of cAMP in the regulation of production of LIPs and MNPs was investigated in this study. Production of LIPs and MNPs was preceded by a sharp rise in intracellular cAMP concentration. Addition of atropine, theophylline, or histamine to cultures resulted in a drop in intracellular cAMP concentration and a concomitant inhibition of production of LIPs only or of both LIPs and MNPs, depending on the concentration of the inhibitor added. These results were independently confirmed by fast protein liquid chromatographic profiles of the LIPs and MNPs in the extracellular fluid of the inhibitor-treated and untreated control cultures. LIP production was generally more sensitive to the inhibitors than MNP production. Northern blot analyses showed that the inhibitors affect the production of LIPs and MNPs at the level of transcription. Furthermore, LIP and MNP gene expression appears to be differentially regulated depending on the intracellular concentration of cAMP. These results show that cAMP plays a key role in the regulation of production of LIPs and MNPs in P. chrysosporium.
Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents (2020)

This letter reports the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as delivery systems that could potentially encapsulate and improve the administration of radiotherapeutic anticancer agents. Different metal ions (Ba, Gd, and Ce) were used as surrogates of α-emitting radionuclides (223Ra, 225Ac, and 227Th), and their encapsulation within the PLGA NPs (Dh < 300 nm) was evaluated. The initial concentration of metal ions, the metal salt (nitrate vs chloride), and the presence of chelators influenced the concentration of surrogate ions within the PLGA NPs. This letter shows the potential of PLGA NPs to encapsulate radionuclides, particularly α-emitters, for their application in nuclear medicine.
ChemInform Abstract: POTENTIAL HYPOLIPIDEMIC AGENTS DERIVED FROM 3‐HYDROXY‐17,17‐DIMETHYLGONA‐1,3,5(10),8,11,13‐HEXAENE (1977)

Abstract (V) substituiert und auf hygoligidämische Aktivität untersucht.
Heterozygous MZ Alpha-1-Antitrypsin Deficiency in Adults with Chronic Liver Disease (1990)

Pi phenotype was determined in 335 patients with liver diseases and compared with the results in 2830 healthy blood donors. Eleven of 335 patients had phenotype MZ (3.3%, compared with 2.9% in healthy blood donors (NS]. None of 53 patients with autoimmune chronic active hepatitis had the MZ phenotype, but it was found in 2 of 18 patients (11.1%) with cryptogenic cirrhosis, 3 of 78 (3.8%) with alcoholic liver cirrhosis, 2 of 36 (5.6%) with primary sclerosing cholangitis, and 1 of 26 (3.9%) with primary biliary cirrhosis. Altogether, 3 of 335 patients were homozygous for Pi ZZ and had cirrhosis. One of them (a male) developed a hepatoma and died. We conclude that the reported association between Pi MZ phenotype and chronic non-B active hepatitis does not seem to include patients with autoimmune chronic active hepatitis, whereas the possibility of an association between cryptogenic cirrhosis and the MZ phenotype cannot be excluded.
Therapeutic effects of a new quinolone, DU-6859a, on polymicrobial infections in a newly designed model of rat uterine endometritis (1998)

We evaluated the efficacy of a new quinolone, DU-6859a, using a new model of rat uterine endometritis. Rats were infected with mixed inocula of Escherichia coli and Bacteroides fragilis. The MICs of DU-6859a and levofloxacin against E. coli were 0.025 and 0.05 mg/L, respectively; those against B. fragilis were 0.20 and 0.39 mg/L, respectively. Immediately after inoculating 10 5 cfu/rat of each organism, DU-6859a or levofloxacin (20 mg/kg po bid or tid, respectively, for 3 days) was administered and compared with the untreated group. The viable cell counts of E. coli and B. fragilis in the DU-6859a-and levofloxacin-treated groups were significantly lower than those in the untreated group. These results suggest that DU-6859a would be useful for treating polymicrobial infections in uterine endometritis.
Spray Deposition Processing of Al/SiC MMC Armor Materials and Ta Alloys for Army Applications (1998)

Abstract : In this research program, the spray atomization and deposition technique was both experimentally and numerically studied to process ceramic particulate reinforced (including functionally graded reinforcement distributions) A1 alloy metal matrix composites (MMCs) as armor materials and Ta alloys for Army applications such as shaped charged liners and explosively formed projectiles. In this final progress report, the aforementioned experimental and numerical results are described and discussed in five individual sections, which are described as follows: investigation of thermal residual stresses in layered SiC/A1 composite using the finite element method and X-ray diffraction; spray forming and co-injection of particle reinforced TiA1/TiB2 composites; spray atomization and deposition of tantalum alloys; low pressure spray forming; modeling of porosity during spray forming; and a summary on the investigation on creep behavior of Al alloys and SiC/A1 composites.
Risk Factors for Postcesarean Maternal Infection in a Trial of Extended-Spectrum Antibiotic Prophylaxis (2017)

ClinicalTrials.gov, https://clinicaltrials.gov, NCT012235546.
Extracting Features for Cardiovascular Disease Classification Based on Ballistocardiography (2015)

Cardiovascular disease affects the health of people seriously in the world, especially in the elderly. This paper proposes an effective approach of detecting and analyzing the health status of the elderly. In this work, we continuously acquire Ballisto cardiography (BCG) signal with the micro-movement sensitive mattress (MSM) during non-intrusive sleep in home environment. In the paper, we propose a new method to extract heartbeat intervals (RR) based on Ensemble Empirical Mode Decomposition (EEMD), and extract the signal features by calculating the parameters of heart rate variability (HRV) from time domain analysis, frequency domain analysis and nonlinear analysis. A Naïve Bayesian Classification method is applied to classify the normal persons, hypertension patients and coronary heart disease (CHD) patients by using the obtained features. The proposed method is evaluated by using the BCG datasets from eighteen subjects, including eight females and ten males (age 40-72). The results are satisfactory and can provide a classification precision of 92.3%.
Microstrip near-field focusing for microwave non-invasive breast cancer thermotherapy (2014)

In this paper, a novel focusing method in non-invasive microwave thermotherapy for breast cancer is proposed. Since the antennas used in the non-invasive microwave thermotherapy devices are no longer working as a far field transmitter, only its near field characteristics are critical to the performance of the system, design methods and principles have to be refreshed towards a better thermotherapy device. The method proposed in this paper focuses on the application of microstrip structure in these systems, is based on the nature of near field characteristic of microstrip antenna, thus to enhance the energy density of the target area. This novel device will achieve near field focusing effect by using single antenna, instead of antenna array, lenses or other methods that are usually utilized in communication systems. The focusing effect is verified and demonstrated by well-designed numerical experiments, and the results show that this method is very promising in the treatment of breast cancer.
Systematic review of evidence for the benefits of telemedicine (2002)

A systematic review of telemedicine assessments based on searches of electronic databases between 1966 and December 2000 identified 66 scientifically credible studies that included comparison with a non-telemedicine alternative and that reported administrative changes, patient outcomes, or results of economic assessment. Thirty-seven of the studies (56%) suggested that telemedicine had advantages over the alternative approach, 24 (36%) also drew attention to some negative aspects or were unclear whether telemedicine had advantages and five (8%) found that the alternative approach had advantages over telemedicine. The most convincing evidence on the efficacy and effectiveness of telemedicine was given by some of the studies on teleradiology (especially neurosurgical applications), telemental health, transmission of echocardiographic images, teledermatology, home telecare and on some medical consultations. However, even in these applications, most of the available literature referred only to pilot projects and to short-term outcomes. Few papers considered the long-term or routine use of telemedicine. For several applications, including teleradiology, savings and sometimes clinical benefit were obtained through avoidance of travel and associated delays. Studies of home care and monitoring applications showed convincing evidence of benefit, while those on teledermatology indicated that there were cost disadvantages to health-care providers, although not to patients. Forty-four of the studies (67%) appeared to have potential to influence future decisions on the telemedicine application under consideration. However, a number of these had methodological limitations. Although useful clinical and economic outcomes data have been obtained for some telemedicine applications, good-quality studies are still scarce and the generalizability of most assessment findings is rather limited.
Optically Triggered Melting of DNA on Individual Semiconducting Carbon Nanotubes (2017)

Optical excitation of nanostructures is known to induce local heating, a phenomenon that has been intensely exploited for drug release, gene delivery, cancer thermotherapy, and energy harvesting. However, the effect is typically small requiring collective heating of a large concentration or aggregates of particles. Herein, we show that optical excitation of individual semiconducting single-walled carbon nanotubes triggers strongly localized heating adequate to melt non-covalently attached double-stranded oligonucleotides in solution. In contrast to conventional thermal dehybridization, this optically triggered DNA melting occurs at a solution temperature that is 22 °C lower than the DNA melting temperature. This unexpectedly large localized optical heating effect provides important new insights to design selective optical nanoheaters at the single particle level.
Three-dimensional simulation of VAN LC configurations for advanced LCOS display panels (2006)

LCOS VAN microdisplays are rapidly evolving to be the devices of choice for high-end projection applications. With the advent of very high pixel count devices such as the so-called 8Mpixel displays, it becomes worthwhile to explore the characteristics of the fringe fields and their consequences in such devices in more detail. This paper describes the implementation and application of a three-dimensional simulator that enables us to maximise the optical performance of upcoming 8Mpixel microdisplays by tuning the liquid crystal parameters to their optimal values.
The Effects of Exercise on the Biomechanical and Biochemical Properties of Swine Digital Flexor Tendons (1981)

The digital flexor tendons of the miniature swine were studied after 12 mo of running exercise. Using a newly developed methodology whereby the properties of tendon substance and tendon-bone composite are measured simultaneously, it was found that training augments the strength of the tendon insertion site, but has minimal effect on the tendon substance. Biochemical analyses also showed that the collagen concentration in the tendon substance remains unchanged following exercise. There was also moderate, but not significant, tendon hypertrophy. The present results on flexor tendon differ from those previously obtained for the swine digital extensors [6]. Such difference in response to functional stress may be attributed to the biochemical composition and mechanical properties of these tissues.
A Study of Stress Relaxation Processes in Crosslinked Polyethylene (2014)

The results of tests of the stress relaxation in crosslinked polyethylene under different conditions are presented. With the use of relaxation kernels for describing the experimental data, the mechanism of the relaxation process has been determined, and the dependences of the stresses and Young's modulus over time at different temperatures and strains have been obtained.
Early cardiac evaluation in children with non‐specific mitochondrial disease with isolated mitochondrial respiratory chain complex I defect (2012)

The potentially severe cardiac involvement observed in our subjects suggests that early cardiac evaluation after confirming the diagnosis of MD and regular follow-up tests should be strongly recommended in children even in cases without typical cardiac manifestations.
Three-axes monolithic silicon low-g accelerometer (2000)

In this paper, four different designs for a new three-axes monolithic low-g acceleration sensor are presented. The silicon spring mass system of the sensor is fabricated in a single step by anisotropic wet chemical etching in KOH using [111] planes as physical etch stop. The orientation of the supporting beams of the spring-mass systems allows the seismic mass to move in a direction orthogonal to the [111] planes. Four mass-spring systems, each one rotated by 90/spl deg/, enables the detection of three components of the acceleration vector using capacitive readout. Two alignment structures are presented meeting the high requirements in terms of mask alignment, which are necessary when using the described etch technique. A new space saving compensation structure protecting the convex edges of the seismic masses during the etch process was realized and compared with standard solutions. The sensors performance was characterized and is demonstrated.
Control of electrical conductivity in laser deposited SrTiO3 thin films with Nb doping (1994)

Nb-doped SrTiO3 (STO) thin films (Nb, 0&amp;lt;x&amp;lt;100 mol%) with a-axis orientation have been prepared on nondoped STO (100) and LaAlO3 (100) single crystals using a pulsed laser deposition technique. Solid-solution films are formed between STO and SrNbO3 without any impurity phases. Electrical conductivities of Nb-doped STO films can be controlled from 10−7 to 104 S/cm by changing the concentration of the doped Nb. Carrier concentration of the Nb-doped STO films also increases by increasing the Nb concentration.
Hydrogen Dissociation on Reconstructed ZnO Surfaces (1996)

Atomistic modeling of reconstructions and relaxation of the nonpolar (101̄0) and (112̄0) ZnO surfaces has been performed to obtain more realistic surface structures for embedded cluster quantum chemical calculations of the reactivity of ZnO toward H2 dissociation. Only small differential geometrical effects are found for the cation and anion top-layer relaxations. Both surfaces are found to be unreactive toward H2 dissociation. For the polar, Zn-terminated (0001) surface several different reconstructions were studied; the lowest surface energy was obtained for a 4×4 reconstruction containing single-step plateaus and valleys. The highest exothermicity was found for H2 dissociation over a corner site, involving a low-coordination oxygen, on the plateau. The edge sites on the plateau also lead to exothermic reactions, while the regular sites between plateaus are unreactive. The determining factor for the exothermicity is the coordination of the anion, but the ionization potential at the anion site also shows a correlation with the exothermicity. No cooperative effects were found. The vibrational frequencies were computed in qualitative agreement with experiment for the O−H vibration, while the strong experimental Zn−H peak at 1710 cm-1 has not been reproduced. The quantum chemically computed chargeson the ions are found to vary with coordination and position; this could have an effect on the atomistic modeling which presently does not include coordination-dependent terms in the potentials. Using an unembedded, gas-phase ZnO unit as a model leads to unrealistically high reaction energies; this is also the case if reconstruction of the (0001) surface is neglected. This demonstrates the need to develop realistic embedding schemes.
Cl-doping of Te-rich CdTe: Complex formation, self-compensation and self-purification from first principles (2015)

The coexistence in Te-rich CdTe of substitutional Cl-dopants, ClTe, which act as donors, and Cd vacancies, VCd−1, which act as electron traps, was studied from first principles utilising the HSE06 hybrid functional. We find ClTe to preferably bind to VCd−1 and to form an acceptor complex, (ClTe–VCd)−1. The complex has a (0,-1) charge transfer level close to the valence band and shows no trap state (deep level) in the band gap. During the complex formation, the defect state of VCd−1 is annihilated and leaves the Cl-doped CdTe bandgap without any trap states (self-purification). We calculate Cl-doped CdTe to be semi-insulating with a Fermi energy close to midgap. We calculate the formation energy of the complex to be sufficiently low to allow for spontanous defect formation upon Cl-doping (self-compensation). In addition, we quantitatively analyse the geometries, DOS, binding energies and formation energies of the (ClTe–VCd) complexes.
Analysis and Quantification of Wellbore Tortuosity (2016)

Summary Small-scale wellbore tortuosity—variations in attitude on a length scale smaller than standard survey intervals of 30 m (100 ft)—is generally neglected because of its small effect on the final position of the well and its unclear relation to traditional dogleg severity (DLS). However, it is well-known that such tortuosity may have significant influence on the drilling process and on drilling efficiency. Furthermore, it is a crucial factor for the design and installation of completions and production equipment, because a highly tortuous wellbore section, depending on borehole diameter and tortuosity amplitude and along-hole distribution, may exert strong bending forces on such equipment, or high friction on moving parts. This paper describes a novel methodology for analyzing the tortuosity of openhole wellbores, casing, drillstring, and production tubing. Several related tortuosity parameters are described, and examples of application to field data are included. The methods use high-resolution survey data [measured depth (MD), inclination, and azimuth], which may, in principle, originate from any surveying tool or service capable of providing such data. The methodology requires input data from a single survey only. On the basis of a user-defined length as single external parameter, tortuosity can be analyzed on any length scale greater than approximately 10 times the input survey-data interval, and with a maximum resolution equaling twice the data interval. The processed parameters include relative elongation of a tortuous section compared with a straight-line section, transverse displacements from the straight line, and maximum available diameter for a downhole device caused by the small-scale bendings of the section. The results can be displayed as graphs vs. MD, or as 3D-rendered views of the actual wellbore or tubing shape. Results from various field cases are included, in which the tortuosity analysis was applied to high-resolution continuous gyro survey data collected in cased wellbores. In all the field cases, the novel methods revealed sections of considerable tortuosity that were either unnoticed, or located with unacceptably low accuracy, by conventional methods. These results led to re-evaluation of the planned locations for completion and production equipment. The characterization of the wellbore in terms of tortuosity on various length scales may be of crucial importance for the functionality and lifetime of permanently installed equipment. For example, identification of highly tortuous sections will aid the placement of rod-guide wear sleeves, increasing the rod and casing life and reducing the workover frequency. Another application is the identification of low-tortuosity sections in which downhole pumps or other equipment will not be subject to excess bending. In addition, the tortuosity results may help evaluate the drilling equipment and the drilling process.
[Analyses of lipid hydroperoxides and physiologically active lipids by mass spectrometry]. (2014)

Numerous studies have been conducted on lipid oxidation in relation to atherosclerosis, inflammation, and various diseases. This review briefly presents the methods of liquid chromatography-electrospray ionization mass spectrometry (LC/MS) for lipid peroxides, and the physiologically active lipid plasmalogen.
New Subsections for JPC A/B/C and JPC Letters (2012)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNew Subsections for JPC A/B/C and JPC LettersAnne B. McCoy, Sharon Hammes-Schiffer, Catherine J. Murphy, Prashant Kamat, and George C. SchatzCite this: J. Phys. Chem. A 2012, 116, 14, 3507Publication Date (Web):April 12, 2012Publication History Published online12 April 2012Published inissue 12 April 2012https://pubs.acs.org/doi/10.1021/jp303176dhttps://doi.org/10.1021/jp303176deditorialACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views645Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (113 KB) Get e-AlertscloseSUBJECTS:Energy conversion,Geochemistry,Physical chemistry,Space chemistry Get e-Alerts
A multilayer Si/CNT coaxial nanofiber LIB anode with a high areal capacity (2013)

Si/carbon nanotube (CNT) nanocomposites are ideal anode materials for lithium ion batteries with high specific capacities. However, it has been a significant challenge to fabricate uniform Si/CNT nanocomposite anodes with high areal capacities, say above 0.4 mA h cm−2. In this paper, we demonstrate a layer-by-layer assembling technique as a facile and scalable method to prepare a multilayer Si/CNT coaxial nanofiber anode which possesses an areal storage capacity above 1 mA h cm−2. In addition, the prepared Si/CNT coaxial nanofiber anodes show an excellent cyclability. The excellent performance of the Si/CNT coaxial nanofiber multilayer anodes is attributed to the unique nanostructure. The CNT network matrix offers mechanical support to accommodate the stress associated with the large volume change of Si coating and the nanoporous multilayer structure provides continuous paths for Li ion and electron transport.