gebhart/patrepeval huggingface dataset:
Recent Progress in Aerobic Oxidation of Hydrocarbons by N‐Hydroxyimides (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Human Apolipoprotein E Resequencing by Proteomic Analysis and Its Application to Serotyping (2014)

Our novel ApoE serotyping method with protein resequencing requires no synthesis of stable isotope-labeled peptides or genome analysis. The method can use residual blood from samples collected for routine clinical tests, thus enabling retrospective studies with preserved body fluids. The test could be applied to samples from subjects whose DNA is unavailable. In future studies, we hope to demonstrate the capability of our method to detect rare ApoE mutations.
Saving power by mapping finite-state machines into embedded memory blocks in FPGAs (2004)

Modern FPGAs contain on-chip synchronous embedded memory blocks (SEMBs), these memory blocks can be used to implement control units, when not used as on-chip memory. In this paper, we explore the mapping of finite state machines (FSMs) into the SEMBs for power and area minimization. We have shown the SEMB based implementation of the FSMs and compared it with conventional flip-flop (FF) based implementation. The proposed implementation of the FSMs consumes less power and has lower area and routing overhead than the FF based approach and it can be clocked at the maximum clock frequency supported by the SEMBs. Experimental results show that the SEMB based FSM consumes 4% to 26% less power than the conventional implementation. In addition it is observed that the power consumption can be further reduced by stopping the clock to the SEMBs during the idle states.
FIDEA: a server for the functional interpretation of differential expression analysis (2013)

The results of differential expression analyses provide scientists with hundreds to thousands of differentially expressed genes that need to be interpreted in light of the biology of the specific system under study. This requires mapping the genes to functional classifications that can be, for example, the KEGG pathways or InterPro families they belong to, their GO Molecular Function, Biological Process or Cellular Component. A statistically significant overrepresentation of one or more category terms in the set of differentially expressed genes is an essential step for the interpretation of the biological significance of the results. Ideally, the analysis should be performed by scientists who are well acquainted with the biological problem, as they have a wealth of knowledge about the system and can, more easily than a bioinformatician, discover less obvious and, therefore, more interesting relationships. To allow experimentalists to explore their data in an easy and at the same time exhaustive fashion within a single tool and to test their hypothesis quickly and effortlessly, we developed FIDEA. The FIDEA server is located at http://www.biocomputing.it/fidea; it is free and open to all users, and there is no login requirement.
Interaction of magnesium and inorganic phosphate with calcium-deprived sarcoplasmic reticulum adenosine triphosphatase as reflected by organic solvent induced perturbation (1985)

The mechanism of sarcoplasmic reticulum (SR) ATPase Mg2+-dependent phosphorylation from Pi was investigated in the presence of 15% v/v dimethyl sulfoxide at pH 6, 20 degrees C, and in the absence of potassium. Measurements of intrinsic fluorescence changes and of 32P-labeled phosphoprotein (*E-P) were in agreement, both at equilibrium and in transient situations. We found that the amount of phosphoenzyme present and its rate of formation depended solely on the concentration of the (Mg X Pi) complex. Up to 6 nmol of phosphate/mg of protein was covalently bound to the enzyme, implying almost complete phosphorylation. Oxygen exchange experiments were also performed in order to allow calculation of the absolute rate constant of *E-P hydrolysis to the noncovalent complex (0.8-1.0 s-1), which differs from the observed rate of enzyme dephosphorylation (0.3-0.5 s-1); in addition, they allowed calculation of the bimolecular rate constant of substrate binding (2-2.4 M-1 s-1). The results demonstrate that in the presence of dimethyl sulfoxide, phosphorylation occurs by the following simple mechanism: relatively slow binding of the neutral substrate (Mg X Pi), with poor affinity, followed by a thermodynamically favorable formation of the covalent bond between phosphate and the possibly hydrophobic active site. The interaction between magnesium and calcium-deprived SR vesicles was studied in the presence of 0-20% v/v dimethyl sulfoxide (or 0-30% v/v glycerol) at pH 7 and 20 degrees C. The presence of either solvent led to the disappearance of the two typical pH-dependent effects we previously characterized for magnesium: loss of the Mg2+-induced spectral shift of tryptophan fluorescence emission and loss of the biphasic pattern displayed by the intrinsic fluorescence rise after addition of calcium to Ca2+-deprived Mg2+-preincubated vesicles. In the absence of solvent, the interaction of magnesium with the calcium-deprived ATPase was also characterized from the point of view of phosphoenzyme formation from ATP or Pi at pH 7 in the absence of potassium: we found that calcium-independent phosphorylation was slower when phosphate was added to SR vesicles preincubated with magnesium that when magnesium was added to vesicles preincubated with phosphate, suggesting that preincubation with magnesium had depleted the phosphate-reactive conformation of the ATPase. A simple reaction scheme for phosphoenzyme formation is described: it implies that the (Mg X Pi) complex is a substrate for this reaction, whereas the Mg2+ itself acts as a pH-dependent, dimethyl sulfoxide sensitive inhibitor of full enzyme phosphorylation.(ABSTRACT TRUNCATED AT 400 WORDS)
Multimodal image re-registration via mutual information to account for initial tissue motion during image-guided neurosurgery (2005)

Multimodal imaging modalities, such as high-resolution pre-operative MR (pMR) and intra-operative US (iUS), have been used widely to provide complementary information for guiding neurosurgery. Proper registration between the images is usually established fiducials placed on the patient skull, which can be identified both in MR and a tracking system that also records location and orientation of each iUS scan. Although such systems can achieve high registration accuracy, we have observed brain tissue motion with respect to the skull after the craniotomy and before opening of the dura. We developed a rigid registration strategy to re-align the brain in iUS and pMR to account for such motion. The mutual information between the two modalities is maximized through a genetic algorithm. Two patient cases are presented to show the improved registration accuracy of soft tissues.
Solid Oxide Cell Performance: Spatially Resolved Oxygen Electrode Stability (2023)

Several aspects of TNO SOC performance characteristics will be discussed, with a focus on steam electrolysis performance and lifetime behaviour during endurance tests of several thousand hours. Excellent steam electrolysis performance of the TNO SOE cells is observed at thermoneutral voltage, achieving current density values of −1.7 A/cm 2 at an operating temperature of 750 ° C. Lifetime assessment and material degradation of the SOC will be discussed, with a focus on the analysis of observed degradation phenomena in the oxygen electrode material. As oxygen electrode degradation can be critical for SOC performance in a stack environment, it is important to have a good understanding of the degradation processes and the ability to monitor them. At TNO, a novel approach of high-resolution 2D mapping of the lateral conductivity of the oxygen electrode has been used as an effective tool for quality control and validation of the oxygen electrode development. Additionally, the combination of 2D sheet resistance mapping, SEM-EDX and XRD techniques provides a powerful combination of tools to obtain a spatially resolved (3D) view of the localized degradation observed in the oxygen electrode after several thousand hours of steam electrolysis.
Fast pre-authentication with minimized overhead and high security for WLAN handoff (2008)

Abstract- User mobility in WLANs becomes more and more popular because of wide deployment of WLANs and numerous applications on it. Some of these applications, for example multimedia applications, require fast handoffs among access points to maintain the quality of service. In order to support multimedia applications for roaming users, IEEE 802.11i defines pre-authentication to reduce the re-authentication delay. The primary drawback of IEEE 802.11i pre-authentication is that the full 802.1x/EAP authentication consumes too much overhead. In this paper, we propose a new fast pre-authentication scheme that greatly improves the efficiency and achieves high security level.
RECENT PROGRESS OF DIAMOND DEVICE TOWARD POWER APPLICATION (2012)

The state of the art of the Institut Néel research activity in the field of diamond power devices will be described and discussed. The active layers of the device are based on boron-doped monocristalline (100) diamond (with doping level varying between 1014 to 1021 cm-3) grown on Ib high temperature high pressure (HPHT) diamond substrate. The progresses done on diamond/metal interface, diamond/dielectric interface, or sharp gradient doping, permit recently the fabrication of original structures and devices, which will be detailed here (Schottky diode, boron doped δ-FET and MOS capacitance).
Method of forming novel curved-line gratings and their use as reflectors and resonators in integrated optics (1977)

Gratings have been used as Bragg reflectors in integrated optics for a variety of the applications. We report here a method of forming novel curved-line gratings and analyze their use for imaging in optical circuits and as the resonators in diode lasers.
An Integrated Physical Map for the Short Arm of Human Chromosome 5 (1999)

The short arm of human chromosome 5 contains approximately 48 Mb of DNA and comprises 1.5% of the genome. We have constructed a mega-YAC/ STS map of this region that includes 436 YACs anchored by 216 STSs. By combining and integrating our map with the 5p maps of other groups using the same recombinant DNA library, a comprehensive map was constructed that includes 552 YACs and 504 markers. The YAC map covers >94% of 5p in four YAC contigs, bridges the centromere, and includes an additional 5 Mb of 5q DNA. The average marker density is 95 kb. This integrated 5p map will serve as a resource for the continuing localization of genes on the short arm of human chromosome 5 and as a framework for both generating and aligning the DNA sequence of this region.
Pre-eclampsia and magnesium toxicity with therapeutic plasma level in a woman with m.3243A>G melas mutation (2008)

"Pre-eclampsia and magnesium toxicity with therapeutic plasma level in a woman with m.3243A>G melas mutation." Journal of Obstetrics and Gynaecology, 28(3), p. 349
In vivo photoacoustic potassium imaging of the tumor microenvironment (2020)

The accumulation of potassium (K<sup>+</sup>) in the tumor microenvironment (TME) has been recently shown to inhibit immune cell efficacy, and thus immunotherapy. Despite the abundance of K<sup>+</sup> in the body, few ways exist to measure it <i>in vivo</i>. To address this technology gap, we combine an optical K<sup>+</sup> nanosensor with photoacoustic (PA) imaging. Using multi-wavelength deconvolution, we are able to quantitatively evaluate the TME K<sup>+</sup> concentration <i>in vivo</i>, and its distribution. Significantly elevated K<sup>+</sup> levels were found in the TME, with an average concentration of approximately 29 mM, compared to 19 mM found in muscle. These PA measurements were confirmed by extraction of the tumor interstitial fluid and subsequent measurement via inductively coupled plasma mass spectrometry.
The pumping of double-clad neodymium fiber (2004)

The paper presents a new method of pumping lasers built on the basis of double-clad neodymium-ion doped lasers. The asymmetrical couplers were realized by grinding and built on a multi-mode PCS (pumping) fiber and a double-clad (pumped) fiber. Special software for designing such asymmetrical couplers was elaborated. It allows us to choose appropriate parameters of the coupler's elements, enabling us to obtain a maximum pumping power, introduced by the purpose-built coupler.
Effective Use of BCH-2763, a New Potent Injectable Direct Thrombin Inhibitor, in Combination with Tissue Plasminogen Activator (tPA) in a Rat Arterial Thrombolysis Model (1998)

Current therapeutic use of heparin as an adjunct to thrombolytic therapy for myocardial infarction is suboptimal with respect to efficacy and bleeding risk. In a rat carotid arterial thrombolysis model (FeCl3-induced injury) we evaluated the combined effect of tPA (2.0 mg/kg/30 min) with our potent injectable direct thrombin inhibitor, BCH-2763 (Ki 0.11 nM; MW 1.5 kDa), which, unlike heparin, inhibits bound and free thrombin; comparisons were with standard heparin (SH), other direct thrombin inhibitors, r-hirudin (MW 6.5 kDa) and hirulog (MW 2.3 kDa), or tPA alone. Time to lysis (TL), patency time (PT), aPTT (fold increase) and bleeding time (BT) were determined. ED100 (100% of rats reperfused) for BCH-2763, hirulog or r-hirudin was 1, 3 or 2 mg/kg/60 min, respectively; 67% of rats reperfused with SH at the highest dose tested (220 U/kg/60 min) and 43% with tPA alone. At these doses, TL (min) was shorter (p < 0.01) with BCH-2763 (0.5 +/- 0.1), hirulog (3.3 +/- 2.3) or r-hirudin (2.3 +/- 1.0) than SH (66.3 +/- 30.8) or tPA alone (93.4 +/- 21.4). The aPTT fold increase after 15 min infusion was markedly greater (p < 0.001) for SH (32.0 +/- 0.8) than BCH-2763 (3.7 +/- 0.5), hirulog (5.2 +/- 0.3) or r-hirudin (4.5 +/- 0.8) in combination with tPA or tPA alone (1.1 +/- 0.1). In addition, the BT (min) for BCH-2763 (3.0 +/- 0.4) was similar to tPA alone (1.6 +/- 0.3), but prolonged (p < 0.05) for hirulog (7.5 +/- 2.7), r-hirudin (6.6 +/- 0.8) or SH (7.3 +/- 1.8). Comparisons at same aPTT fold increase revealed that in combination with tPA, BCH-2763 required a lower anticoagulant level to shorten the TL and prolong the PT than hirulog, r-hirudin or SH. Thus, in this rat arterial thrombolysis model direct thrombin inhibitors are more effective than SH as antithrombotic adjuncts to tPA. BCH-2763 is effective at a lower gravimetric dose and more modest aPTT fold increase than hirulog or r-hirudin with less alteration in haemostasis, which may confer an improved safety index.
How Does Monomer Structure Affect the Interfacial Dynamics of Supported Ultrathin Polymer Films? (2020)

We utilize recently introduced chemically specific but coarse-grained models of poly(ethylene oxide) (PEO) and poly(methyl methacrylate) (PMMA) to explore the influence of monomer architecture on the dynamics of supported thin polymer films based on molecular dynamics simulations. In particular, we contrast differences in the molecular packing and mobility gradients in these materials near the substrate and “free” interface regions. As expected, relaxation is generally enhanced in the free surface region relative to the film interior (and bulk), and the degree of enhancement is similar for both PEO and PMMA. However, the dynamical changes near the substrate are more sensitive to monomer structure, and are enhanced with increasing polymer–substrate interaction strength, ε. PMMA is relatively stiff compared to PEO and has a side group of appreciable size, and we find that the dynamics of PMMA near the substrate are slowed significantly more in comparison to PEO for the same substrate. Substrate interactions lead to a notable difference of local fragility near the substrate that appears to arise from a higher cohesive interaction strength of the PMMA chains in this region. Our data also reveal the inadequacy of the these coarse-grained polymer models to reproduce the experimentally known differences in the fragility of these materials. However, this technical shortcoming is not expected to alter our qualitative conclusions regarding the comparative effect of substrate interactions on relatively flexible polymers such as PEO versus a relatively stiff polymer such as PMMA.
Combined analog/digital approach to performance optimization for the LAPET whole-body TOF PET scanner (2012)

LAPET is a LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -based whole-body time-of-flight PET scanner. We previously reported coincidence timing resolution 315-330 ps (fwhm) in benchtop measurements and 375 ps in full-system measurements. We are currently testing prototype units for a complete redesign of LAPET's electronics, aimed at further improving full-system timing performance and at preserving that performance at high count rates. We report on four facets of the new design. First, PMT-by-PMT high-voltage control at two points per dynode chain permits both gains and timing offsets to be equalized across the scanner. Second, analog pulse shaping reduces the duration of each PMT pulse from 75 ns to 35 ns, reducing pile-up effects. Third, custom circuit boards use the DRS4 waveform-sampling ASIC to provide oscilloscope-quality readout of each PMT signal, enabling digital processing of PMT waveforms. Finally, an FPGA-based trigger provides the coarse energy and timing measurements used to detect coincident pairs. Tests are underway of prototype High Voltage Control boards, Shaper/Analog Mezzanine cards, and the DRS4-based Module Readout Board; the Master Coincidence Unit design is in progress.
Successful treatment of adult respiratory distress syndrome by histamine and prostaglandin blockade in a porcine Pseudomonas model. (1987)

Porcine Pseudomonas adult respiratory distress syndrome (ARDS) has been shown to respond to combination therapy of 150 mg of cimetidine, 12.5 mg/kg of ibuprofen, 10 mg/kg of diphenhydramine, 0.2 mg/kg of ketanserin, and 30 mg/kg of methylprednisolone (CIDKM or Poly-5) given at 20 and 120 minutes after the onset of a continuous infusion of liver Pseudomonas aeruginosa, 5 X 10(8) colony-forming units (CFU) ml at 0.3 ml/20 kg/min. The present study was designed to determine the minimal, effective therapy by selective deletion of individual agents from CIDKM. Eight groups were studied: saline control (S, n = 9), Pseudomonas control (P, n = 8), and the following Pseudomonas plus treatment groups (each n = 5): CIDKM (cimetidine, ibuprofen, diphenhydramine, and ketanserin), CID (cimetidine, ibuprofen, and diphenhydramine), IC (ibuprofen and cimetidine), ID (ibuprofen and diphenhydramine), and CD (cimetidine and diphenhydramine). Pseudomonas alone produced severe ARDS with significant (p less than .05) decreases in PAO2 cardiac index, and systemic arterial pressure and significant increases in pulmonary artery pressure, extravascular lung water (EVLW) and scintigraphically determined pulmonary albumin flux measured as slope index (SI). Full therapy, CIDKM or Poly-5, showed significant improvement in all parameters. Deletion of methylprednisolone did not significantly effect any parameter measured. The deletion of ketanserin, leaving CID, did not alter treatment efficacy, except for a significant decline in cardiac index at 3 hours. Deletion of ibuprofen from CID resulted in a failure to reverse pulmonary arterial hypertension, hypoxemia, elevated EVLW, and increased SI. Removal of either cimetidine or diphenhydramine from CID resulted in significant increases in EVLW compared with control levels and SI compared with both control levels and CID. These results indicate that a combination of both histamine H1 and H2 receptor blockers and the cyclooxygenase inhibitor, ibuprofen, is effective and essential in the treatment of hypoxemia, early pulmonary hypertension, and pulmonary microvascular injury in this fulminant model of porcine Pseudomonas ARDS.
Miniature gear reduction unit driven by a silicon electrostatic wobble motor (2002)

This work illustrates and explores one possibility to link watch fine mechanics to silicon-based actuators. A small scale microreduction module, a pinion-gear train, coupled to an electrostatic wobble motor (calculated power figure about 1 /spl mu/W), is described. The motor parts are fabricated on silicon. Electrodeposition of nickel in a positive photoresist mould is used for the fabrication of the rotor (/spl phi/ 2 mm). This last is flexible to permit vertically- wobbling and is directly connected to an output shaft. Functional operation of this microreduction unit was successful and demonstrated the possibility to output torque from an electrostatic wobble motor. Measurements and observations of rotor elasticity and gears/axle characteristics:are presented and discussed in view of a possibly improved design.
Lossless current sensing and its application in current mode control (2008)

In this paper, it is revealed that the lossless current sensing structure is very similar to the well known Maxwell bridge. The matching condition in lossless current sensing is the same as the balance equation in Maxwell bridge. In practice, it is difficult to meet the matching condition due to the parameter value variations. However, it is shown that in current mode control, at certain time constant mismatching situations, the circuit dynamic response actually could be improved. Furthermore, a “speedy capacitor” could be added to the lossless current sensing circuitry to significantly improve the sensed current signal to noise ratio and avoid jittery operation in wide DC-DC conversion ratio applications.
Modelling the Air Ticket Purchase Behavior Incorporating Latent Class Model (2020)

As passengers are proved to be preference heterogeneous in air travel, this paper tries to model the air ticket purchase behavior incorporating market segmentation. In the research, a latent-NL model, established on the latent class structure and the nested logit model, integrates the personal features as well as the purchase preferences into the forecast of segment-specific purchase probability. In order to calibrate the model, a stated preference survey is designed with the choice profiles using real service information, and the survey is conducted in four cities in China for data collection. The results show that the proposed model provides an effective approach for predicting the air travel demand in particular for air ticket pricing, and the estimation results outperforms the traditional-nested logit model with higher goodness-of-fit. Besides, the model is then adopted to test the efficiency of different pricing strategies, showing its advantages in improving the flight revenues.
Physiological response to color: A critical review (1984)

Abstract Physiological human responses to color as evidenced by the electroencephalogram, galvanic skin response, blood pressure, heart rate, respiration rate, eyeblink frequency, and oxiometry are reviewed. A casual reading of the descriptive literature on the human response to color leads one to the conclusion that color can have rather specific physiological effects. It is concluded from this review that there are reliably recordable physiological responses to color in addition to those generally associated with vision. However, it may be that some are indirect effects mediated by cognitive responses to color.
Adaptive nulling loop control for 1.7-GHz feedforward linearization systems (1997)

An adaptive analog control system is introduced for the nulling loop (first loop) of a 1.7-GHz feedforward linearization system. The sensitivity to temperature and frequency variations is experimentally shown for a conventional feedforward system, leading to the need for an adaptive control system. Two error signals based on detected power levels are introduced and used to control the nulling loop vector modulator to ensure cancellation of the main signal. Finally, the experimental performance of this system is presented.