gebhart/patrepeval huggingface dataset:
LIBO - A 3 GHz Proton Linac Booster of 200 MeV for Cancer Treatment (1998)

Several hospitals and laboratories possess proton cyclotrons with output energies of 60 to 70 MeV. A high frequency (3 GHz) booster linac (LIBO) is proposed to upgrade the cyclotron beam to an energy of 200 MeV, sufficient to treat deep seated tumours. LIBO is a side-coupled linac which can produce beams with a variable output energy. This paper presents the feasibility study of such an accelerator, together with the milestones planned for 1998-1999, including the machining of a part of LIBO and testing it with full RF power on a test stand at CERN. 1
Performance Modification of Chitosan Membranes Induced by Gamma Irradiation (2002)

Trauma of the nervous system often results in permanent functional loss because the spontaneous regeneration of nerves is very difficult. Thus, various methods have been developed to facilitate the restoration of damaged nerve. The biodegradable nerve conduit is one of the most promising methods for nerve regeneration. Chitosan, a natural polysaccharide that has excellent biocompatibility and biodegradability, can be used as conduit material. But, nerves regenerated by nerve conduits made from chitosan have some problems, for example, with their mechanical properties. This article shows that the mechanical properties of chitosan film were markedly improved by selected doses of gamma radiation and cell culturing experiments on the surface of the irradiated chitosan film indicated that the film still has excellent biocompatibility.
SIFME: A Single Iteration Fractional-Pel Motion Estimation Algorithm and Architecture for HDTV Sized H.264 Video Coding (2007)

This paper presents a set of fast algorithm and VLSI architecture for HDTV-sized H.264 fractional motion estimation. To solve the long computational latency in HD-sized application, we propose to use the single iteration algorithm with only six search points. This single iteration method halves the cycle count of two iteration methods in previous approaches. Moreover, we propose to use 4×4 Hadamard instead of 8×8 Hadamard as cost function for H.264 high profiles without significant video quality loss. By these techniques, the resulted architecture can save 20% of area and provide over 40% of throughput improvement than the previous work, and is able to support HDTV applications.
Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design (2020)

Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has been widely appreciated that obesity is a major risk factor for CVD, treatments that produce effective, durable weight loss and the impact of weight reduction in reducing cardiovascular risk have been elusive. Instead, progress in CVD risk reduction has been achieved through medications indicated for controlling lipids, hyperglycemia, blood pressure, heart failure, inflammation, and/or thrombosis. Obesity has been implicated as promoting all these issues, suggesting that sustained, effective weight loss may have independent cardiovascular benefit. GLP-1 receptor agonists (RAs) reduce weight, improve glycemia, decrease cardiovascular events in those with diabetes, and may have additional cardioprotective effects. The GLP-1 RA semaglutide is in phase 3 studies as a medication for obesity treatment at a dose of 2.4 mg subcutaneously (s.c.) once weekly. Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) is a randomized, double-blind, parallel-group trial testing if semaglutide 2.4 mg subcutaneously once weekly is superior to placebo when added to standard of care for preventing major adverse cardiovascular events in patients with established CVD and overweight or obesity but without diabetes. SELECT is the first cardiovascular outcomes trial to evaluate superiority in major adverse cardiovascular events reduction for an antiobesity medication in such a population. As such, SELECT has the potential for advancing new approaches to CVD risk reduction while targeting obesity.
Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications (2019)

Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.
Binding of staphylococcal cell surface polysaccharide to human fibrinogen (1990)

The interaction between the binding site of a polysaccharide (called compact colony forming active substance (CCFAS)), obtained from the cell surface of a strain of Staphylococcus, and human fibrinogen (HF) was investigated. The CCFAS was found to bind specifically to both the B beta and gamma chains of HF at pH 7.0 and 8.0, and the A alpha chain at pH 5.0. The binding of CCFAS with fibrinogen fragments obtained by digestion with plasmin were also investigated. Fragments with Mr of 55,000, 24,000, and 19,000 were the major bands precipitated by CCFAS at pH 7.0 and 8.0. Fragments with Mr of 85,000 and 75,000 bound to CCFAS at pH 5.0. Binding of CCFAS (7 micrograms) with fibrinogen could be inhibited by 1.2 micrograms of B beta chain and 1.5 micrograms gamma chain at alkaline pH or 6.2 micrograms of the A alpha chain at pH 5.0. CCFAS was, therefore, assumed to be specifically bonded with HF molecules, in the alkaline range at least, resulting in compact colony forming activity in serum soft agar and paracoagulation.
Competitive bridgehead substitution in electrophilic oxidation reactions of protoadamantane. Synthesis of 3-protoadamantanol. On the utility of molecular mechanics calculations for predicting the bridgehead reactivity of hydrocarbons with electrophiles (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompetitive bridgehead substitution in electrophilic oxidation reactions of protoadamantane. Synthesis of 3-protoadamantanol. On the utility of molecular mechanics calculations for predicting the bridgehead reactivity of hydrocarbons with electrophilesJames J. Sosnowski, Elizabeth B. Danaher, and Roger K. Murray Jr.Cite this: J. Org. Chem. 1985, 50, 15, 2759–2763Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/jo00215a033https://doi.org/10.1021/jo00215a033research-articleACS PublicationsRequest reuse permissionsArticle Views383Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase II study of olaparib for BRCAness phenotype in pancreatic cancer. (2018)

297 Background: The subtype of pancreatic ductal adenocarcinoma cancer (PDAC) patients with DNA damage repair (DDR) deficiency from BRCA1/2 mutations has a favorable prognosis and is sensitive to platinum analogues and PARP inhibition. About 10-20% of PDAC patients have DDR deficiency without BRCA mutations (BRCA ness). The efficacy of olaparib in this population is unknown. Methods: Two parallel phases II trials (Israel and U.S.) are ongoing to determine the efficacy of olaparib in advanced PDAC with BRCA ness. Inclusion criteria: ≥ 1 prior systemic therapy for advanced PDAC, ECOG 0-1, germline BRCA 1/ 2 ( gBRCA) mutation negative, previously known DDR genetic aberrations (DDR-GA), family history of BRCA-associated cancers in ≥2 first-degree relatives (without DDR-GA), ATM loss by IHC (Israel only). Primary and secondary endpoints are objective response rate and PFS, respectively. With an type I error rate α of 0.1 and a β error rate of 0.2, and assuming P0 and P1 are 5% and 20%, respectively, study will enroll 24 patients at each site. Results: Thus far, 21 and 11 patients treated in Israel and U.S; respectively. DDR phenotype: Family history of BRCA cancer without DDR-GA (n = 14), DDR-GA (n = 12), ATM loss by IHC (n = 5). DDR-GAs were ATM (n = 6), PALB2 (n = 1), BRCA somatic (2), FANCB (1), PTEN (1) and CCNE1 (1). Efficacy data are in Table. Common toxicities were grade 1-2 anemia, fatigue and nausea. No responses were observed in platinum refractory cases. Conclusions: Olaparib was tolerated well in this study population. Olaparib showed encouraging initial antitumor activity in platinum-sensitive, gBRCA negative PDAC patients with DDR GA and in patients with family history of BRCA cancers (without identifiable DDR-GA). Clinical trial information: NCT02677038 ; NCT02511223. [Table: see text]
Functional Requirement for Class I MHC in CNS Development and Plasticity (2000)

Class I major histocompatibility complex (class I MHC) molecules, known to be important for immune responses to antigen, are expressed also by neurons that undergo activity-dependent, long-term structural and synaptic modifications. Here, we show that in mice genetically deficient for cell surface class I MHC or for a class I MHC receptor component, CD3zeta, refinement of connections between retina and central targets during development is incomplete. In the hippocampus of adult mutants, N-methyl-D-aspartate receptor-dependent long-term potentiation (LTP) is enhanced, and long-term depression (LTD) is absent. Specific class I MHC messenger RNAs are expressed by distinct mosaics of neurons, reflecting a potential for diverse neuronal functions. These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS).
A 6.3pJ/b 30Mbps −30dB SIR-tolerant broadband interference-robust human body communication transceiver using time domain signal-interference separation (2018)

Human Body Communication (HBC) provides a low power communication medium for energy constrained wearable/ implantable devices in and around the human body. This paper presents a broadband HBC transceiver implemented in 65nm CMOS that achieves 6.3pJ/b energy efficiency at 30Mbps with -30dB interference-tolerance. Capacitive termination at the receiver end is used to achieve a wideband HBC channel, and Time Domain Signal-Interference Separation (TD-SIS) using Integrating DDR (I-DDR) receiver allows a tolerance of -30 dB Signal to Interference Ratio (SIR) with a BER <;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . The transceiver achieves 18X improvement in energy-efficiency compared to the State-of-the-Art HBC transceivers while being simultaneously broadband (carrier-less, low-energy) and interference-robust. Such order-of-magnitude improvement in energy-efficiency and private communication through the human body may enable applications like closed-loop neuromodulation, health-monitoring, secure authentication among many others.
Einleitung: Wege der Integration im Erziehungs- und Bildungsprozess – internationale Perspektiven (2009)

Die Integration von Kindern und Jugendlichen stellt in heterogenen Gesellschaften einen komplizierten lebensgeschichtlichen Prozess dar, bei dem Institutionen wie Familie und Schule (aber z.B. auch Sozialarbeit, Sport und Kirche) einen wichtigen Stellenwert einnehmen. Der Integrationsprozess kann als Interaktion zwischen der Eigenaktivität der Kinder und Jugendlichen auf der einen Seite und den auf sie bezogenen Institutionen auf der anderen Seite untersucht werden. Beide Seiten haben ihren Anteil am Gelingen (oder Misslingen) dieses Prozesses. Kinder und Jugendliche können erfolgreich in die Gesellschaft hineinwachsen trotz oder wegen der auf sie einwirkenden Institutionen.
Sources hyperfréquences à très haute pureté spectrale à base de mini-résonateurs optique (2008)

phase de développement - Rapport 3 (T0+18)
Railroad Software-Defined Radio (2020)

Transportation Technology Center, Inc. assessed the potential use of a software-defined radio to meet the current and future wireless communication needs of the U.S. railroad industry. FRA funded this project due to the high level of complexity involved in developing requirements and a preferred design approach for such a radio. The project required extensive research, survey, and trade studies of a technology area that has not been widely implemented beyond military applications.\n
Eine einfache Synthese von Tetraalkylammoniumsalzen mit funktionellen Anionen (1978)

Abstract Tetraalkylammoniumsalze 2 mit funktionellen anionischen Gruppen erhält man durch Umsetzung von Tetraalkylammonium‐tetrafluoroboraten mit entsprechenden Kaliumsalzen. — Tertiäre Amine werden von Chlorameisensäure‐methylester zu Trialkylmethylammoniumchloriden 3 methyliert.
Donor selection and management (2015)

Lung transplantation has continued to evolve at a rapid pace since Dr. James Hardy performed the first human lung transplant in Jackson, Mississippi, in 1963. In the subsequent 10 years, 36 lung transplants were performed worldwide with catastrophic failures that usually occurred within a few days following transplantation. In 1981, Dr. Norman Shumway and colleagues successfully performed three heart-lung transplants at Stanford University Hospital; two of the three recipients were alive and well 1 year after transplantation. In 1983, the Toronto group performed the first successful single-lung transplant, and in 1986 they reported their experience and stated that the recipient was leading a normal lifestyle with no limitations.
Securing the commercial Internet (1996)

article Free AccessSecuring the commercial Internet Author: Anish Bhimani Bellcore, Piscataway, NJ Bellcore, Piscataway, NJView Profile Authors Info & Claims Communications of the ACMVolume 39Issue 601 June 1996pp 29–35https://doi.org/10.1145/228503.228509Published:01 June 1996Publication History 170citation4,112DownloadsMetricsTotal Citations170Total Downloads4,112Last 12 Months87Last 6 weeks13 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
GM Powertrain's New VORTEC 4200 Inline 6 Engine (2001)

&lt;div class="htmlview paragraph"&gt;After an absence of nearly two decades from General Motors vehicles, a state-of-the-art all new inline six cylinder engine will be introduced for the 2002 model year as the standard engine in a new line of midsize Sport Utility Vehicles (SUV's). The new &lt;i&gt;VORTEC&lt;/i&gt; 4200 I6 Engine (&lt;span class="xref"&gt;Figure 1&lt;/span&gt;) brings the technical sophistication of premium passenger car engines to the truck market delivering power exceeding most competitor's V8's, with exceptional low and midrange torque, yet providing best in class fuel efficiency. It is designed to provide a high level of reliability, emit low emission levels, exhibit quiet, smooth, and refined engine operation, and is lightweight. The inline configuration provides an elegant solution to meeting customer demands with premium technology. Features include dual overhead cams - four valves per cylinder, variable exhaust valve timing, all aluminum construction for the cylinder block and cylinder head, and electronic throttle control. The engine is being produced at a completely new manufacturing facility, the Flint Engine South Powertrain Plant in Flint, Michigan.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper provides details of the product design and specifications, an overview of the engineering processes used during development of the engine, as well as highlights of the manufacturing system and facility.&lt;/div&gt;
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ (2011)

Activation of poly(ADP-ribose) polymerase (PARP) is an important factor in controlling cell survival or death. As a consequence, therapeutic interventions with PARP-1 inhibitors are sought in different pathological conditions such as cancer, cardiovascular and inflammatory diseases, as well as brain ischemia. In the first part of this work, as a continuation of our efforts in the field, we report the design, synthesis and biological appraisal of novel potent PARP-1 inhibitors. A crystallization experiment is carried out to ascertain the mode of binding to PARP-1 of the most potent compound, namely 2-((dimethylamino)methyl)-9-hydroxythieno[2,3-c]isoquinolin-5(4H)-one (HYDAMTIQ), whilst molecular modeling studies are performed to infer the role of water molecules in ligand binding. In the second part of the work, we discuss the results of HYDAMTIQ in models of brain ischemia as well as its preliminary physicochemical and pharmacokinetic characterization. Collectively, the data obtained qualify HYDAMTIQ as a novel lead candidate for advancement to clinical settings of brain ischemia.
Predicting outcomes of continuous renal replacement therapy using body composition monitoring: a deep-learning approach (2023)

Fluid balance is a critical prognostic factor for patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). This study evaluated whether repeated fluid balance monitoring could improve prognosis in this clinical population. This was a multicenter retrospective study that included 784 patients (mean age, 67.8 years; males, 66.4%) with severe AKI requiring CRRT during 2017-2019 who were treated in eight tertiary hospitals in Korea. Sequential changes in total body water were compared between patients who died (event group) and those who survived (control group) using mixed-effects linear regression analyses. The performance of various machine learning methods, including recurrent neural networks, was compared to that of existing prognostic clinical scores. After adjusting for confounding factors, a marginal benefit of fluid balance was identified for the control group compared to that for the event group (p = 0.074). The deep-learning model using a recurrent neural network with an autoencoder and including fluid balance monitoring provided the best differentiation between the groups (area under the curve, 0.793) compared to 0.604 and 0.606 for SOFA and APACHE II scores, respectively. Our prognostic, deep-learning model underlines the importance of fluid balance monitoring for prognosis assessment among patients receiving CRRT.
MPEG-21: goals and achievements (2003)

MPEG-21 is an open standards-based framework for multimedia delivery and consumption. It aims to enable the use of multimedia resources across a wide range of networks and devices. We discuss MPEG-21's parts, achievements, ongoing activities, and opportunities for new technologies.
Pavimentazioni di supporto ad azioni fotocatalitiche (2007)

Il contenimento delle concentrazioni degli inquinanti atmosferici al di sotto di soglie di sicurezza rappresenta un problema primario, alla luce delle evidenze scientifiche relative all'impatto di queste sostanze sull'ambiente e sulla salute. Il lavora individua provvedimenti efficaci, frutto di anni di attività di ricerca, volti al contributo delle infrastrutture viarie al controllo dell'inquinamento atmosferico.
Disseny d’una antena de televisió per automoció (2006)

En aquest projecte s’han dissenyat, desenvolupat i integrat a l’automobil diferents solucions d’antenes per la recepcio de televisio.
El projecte va sorgir conjuntament amb la unitat de negocis A3, Advanced Automotive Antennas, de Ficosa Internacional amb l’objectiu de dissenyar una antena integrada a l’automobil, no visible per part de l’usuari del vehicle. Les antenes integrades son la solucio per evitar l’us d’antenes externes als automobils, reduint aixi el seu l’impacte visual.
S’ha fet un estudi d’estandards de televisio terrestre, analogic i digital, DVB-T i
DVB-H, i s’han establert unes condicions inicials de disseny de l’antena.
La televisio es transmet en un ample de banda molt extens. Aquest ha estat principal repte del projecte, dissenyar una antena receptora capac d’operar en un rang de frequencies tant ampli tenint en compte la posicio i les limitacions d’espai al vehicle.
Per al disseny de l’antena s’ha apres i utilitzat un software de simulacio que
permet obtenir la caracteritzacio de les antenes previes al seu desenvolupament. Inicialment s’ha realitzat una estructura simple basada en dos monopols i, aplicant tecniques per incrementar l’ample de banda de les antenes, s’ha arribat als dissenys finals. Les millors solucions han estat
implementades, integrades al vehicle i mesurades amb els recursos de l’empresa. Els prototips finals compleixen les especificacions de disseny establertes a
l’inici del projecte. El guany de les solucions implementades compleix les
especificacions que estableix l’estandard DVB-H i ha estat verificat realitzant un test subjectiu de recepcio, a Italia, obtenint resultats satisfactoris.
Finalment s’ha realitzat una comparativa entre les antenes dissenyades en aquest projecte i un sistema d’antenes que es pot trobar actualment al mercat.
Domino Reactions Consisting of Heterocyclization and 1,2‐Migration—Redox‐Neutral and Oxidative Transition‐Metal Catalysis (2011)

Two cats, two paths: two novel domino reactions starting from 6-hydroxy-2-alkyl-2-alkynylcyclohexanones have been discovered. While redox-neutral platinum catalysis gives rise to furans through a sequence of cyclization, 1,2-shift, and Grob fragmentation, oxidative copper catalysis provides an entry to bicyclic 2,3-dihydrofurans. Upon cyclization and oxidation, an unusual benzilic acid rearrangement can take place in this case.
Cardiac involvement in cardiac AL amyloidosis as measured by equilibrium contrast cardiovascular magnetic resonance (2012)

Background Involvement of the heart drives prognosis in Systemic AL Amyloidosis, predicting outcome and influencing therapeutic options. Current methods of cardiac assessment do not allow formal quantification of the amyloid load. We used Equilibrium Contrast Cardiovascular Magnetic Resonance (EQ-CMR) to measure the interstitial compartment of the heart by measuring the myocardial contrast volume of distribution, VDm.