gebhart/patrepeval huggingface dataset:
Comparative Study of High-Linoleic Acid Vegetable Oils for the Production of Conjugated Linoleic Acid (2010)

Conjugated linoleic acid (CLA) is found in small quantities in dairy and beef products. Obtaining optimum dietary CLA levels from these sources requires an increased intake of saturated fat. A 20% CLA soy oil was produced by UV photoisomerization of soy oil linoleic acid (LA), which is naturally low in saturated fat, but no other high-LA vegetable oils have been studied for their potential as CLA-rich oils. The objectives of this research were to (1) compare flax, sunflower, corn, soy, and high-LA safflower oils as sources of CLA-rich vegetable oils using laboratory-scale equipment, (2) compare CLA yields obtained by laboratory-scale and pilot-scale equipment, and (3) compare the oxidative stabilities of laboratory-scale processed oils. High-LA safflower oil produced the most CLA; soy oil produced slightly less, followed by corn, with flax producing very little and sunflower none at all. Minor oil components and turbidity reduced CLA yields, suggesting that oils should be highly refined before CLA production. The pilot-scale system was more effective than the laboratory-scale system due to greater light exposure and larger surface area to volume ratio of the oil samples. The oxidative stabilities of high-LA safflower oil and soy oil were similar before or after irradiation, indicating that these oils are the most suitable for high-CLA production.
Regulation of Autophagy by α1-Antitrypsin: “A Foe of a Foe Is a Friend” (2014)

Autophagy is involved in both the cell protective and the cell death process but its mechanism is largely unknown. The present work unravels a novel intracellular mechanism by which the serpin α1-antitrypsin (AAT) acts as a novel negative regulator of autophagic cell death. For the first time, the role of intracellularly synthesized AAT, other than in liver cells, is demonstrated. Autophagic cell death was induced by N-α-tosyl-L-phenylalanine chloromethyl ketone (TPCK) and tamoxifen. By utilizing a fluorescently tagged TPCK analog, AAT was "fished out" (pulled out) as a TPCK intracellular protein target. The interaction was further verified by competition binding experiments. Both inducers caused downregulation of AAT expression associated with activation of trypsin-like proteases. Furthermore, silencing AAT by siRNA induced autophagic cell death. Moreover, AAT administration to cultured cells prevented autophagic cell death. This new mechanism could have implications in the treatment of diseases by the regulation of AAT levels in which autophagy has a detrimental function. Furthermore, the results imply that the high synthesis of endogenous AAT by cancer cells could provide a novel resistance mechanism of cancer against autophagic cell death.
Diagnosis of Cowper's Glands on Prostate Needle Biopsy (1997)

The presence of normal anatomic structures may be a source of confusion to the pathologist examining prostatic needle biopsies. The morphologic features of Cowper's (bulbourethral) glands incidentally biopsied during transrectal sampling of the prostate have not been described. We reviewed seven cases of Cowper's glands found in prostatic core biopsy specimens. Sections containing Cowper's glands were stained with hematoxylin-eosin, mucicarmine, periodic acid-Schiff's-digest (PAS-D), and antibodies directed at high-molecular-weight cytokeratin (HMWCK), prostate-specific acid phosphatase (PSAP), prostate-specific antigen (PSA), Ulex europaeus agglutinin, and muscle-specific actin. Histologically, Cowper's glands resemble mucinous minor salivary glands entrapped within fascicles of muscle. Lobules of acini composed of cells distended with mucin (mucicarmine and PAS-D positive) were admixed with ducts and ductules composed of hybrid cells with both mucinous and ductular epithelial features. The HMWCK was strongly reactive with the ductular epithelium and demonstrated an attenuated cell lining at the periphery of lobules. The mucinous cytoplasm reacted with U. europaeus, whereas the ductal elements failed to stain. PSAP stains were negative, with PSA positive in most cases. Muscle-specific actin was positive in three cases. Cowper's glands occasionally may be sampled by transrectal needle biopsy. Recognition of this anatomic structure will allow discrimination from low-grade prostatic adenocarcinoma, foamy gland carcinoma, mucinous metaplasia of prostate glands, and atypical glands of undetermined significance.
Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial (2013)

Clinical trial identifier NCT 02000518.
A Conflict Detection Framework for IoT Services in Multi-resident Smart Homes (2020)

We propose a novel framework to detect conflicts among IoT services in a multi-resident smart home. A novel IoT conflict model is proposed considering the functional and non-functional properties of IoT services. We design a conflict ontology that formally represents different types of conflicts. A hybrid conflict detection algorithm is proposed by combining both knowledge-driven and data-driven approaches. Experimental results on real-world datasets show the efficiency of the proposed approach.
Discordant effects of activator protein-1 transcription factor on gene regulation, invasion, and metastasis in spontaneous, radiation-induced, andfos-induced osteosarcomas (1998)

Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform fibroblasts to an invasive phenotype accompanied by the expression of various invasion- and metastasis-associated genes. Here we compared the expression of AP-1-dependent genes and AP-1 activity in cell lines from fos-induced, radiation-induced, and spontaneous osteosarcomas. We showed that the presence of high AP-1 activity was not sufficient for the induction of invasion- and metastasis-associated AP-1-dependent genes in transformed bone cells. Further, we identified the collagenase I and stromelysin 1 gene promoters as suitable tools for the analysis of other factors regulating metastatic progression of osteosarcoma.
RFID-Based Authentication Middleware for Mobile Devices (2010)

Ever-growing popularity of mobile devices, such as smart phones and netbooks, coupled with anytime and anyplace availability of high-speed network access is changing the ways how we compute and communicate. Mobile devices play an increasingly important role in our lives and tend to become representations of our digital selves when we trust these devices with sensitive information. Consequently, the problem of securing mobile devices against unauthorized access has never been more important. We present an RFID-based Authentication Middleware (RFID-AM) that combines point of entry and continuous authentication with transparent on-demand encryption of user files. This paper details the architecture of RFID-AM, discusses its fully functional prototype, and presents experimental results demonstrating its performance in various conditions. This paper also surveys different methods and technologies that have been proposed and implemented on mobile devices.
Social App Accessibility for Deaf Signers (2020)

Social media platforms support the sharing of written text, video, and audio. All of these formats may be inaccessible to people who are deaf or hard of hearing (DHH), particularly those who primarily communicate via sign language, people who we call Deaf signers. We study how Deaf signers engage with social platforms, focusing on how they share content and the barriers they face. We employ a mixed-methods approach involving seven in-depth interviews and a survey of a larger population (n = 60). We find that Deaf signers share the most in written English, despite their desire to share in sign language. We further identify key areas of difficulty in consuming content (e.g., lack of captions for spoken content in videos) and producing content (e.g., captioning signed videos, signing into a phone camera) on social media platforms. Our results both provide novel insights into social media use by Deaf signers and reinforce prior findings on DHH communication more generally, while revealing potential ways to make social media platforms more accessible to Deaf signers.
Synthesis, characterization, DNA binding properties, and solution thermochromism of platinum(II) complexes of the ethidium cation: regiospecificity in a DNA-promoted reaction (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, DNA binding properties, and solution thermochromism of platinum(II) complexes of the ethidium cation: regiospecificity in a DNA-promoted reactionTong Ren, Daniel P. Bancroft, Wesley I. Sundquist, Axel Masschelein, Michael V. Keck, and Stephen J. LippardCite this: J. Am. Chem. Soc. 1993, 115, 24, 11341–11352Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00077a037https://doi.org/10.1021/ja00077a037research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Paraneoplastic Focal Segmental Glomerulosclerosis Associated With Gastrointestinal Stromal Tumors With Cutaneous Metastasis: a Case Report (2021)

Abstract Background: Gastrointestinal stromal tumor (GIST) is one of most common mesenchymal neoplasms occurring in different areas of the gastrointestinal tract. GISTs with cutaneous metastasis is very rare and its rarity cutaneous GISTs have not been well characterized. Focal segmental glomerulosclerosis (FSGS) is also rare among paraneoplastic nephritic syndromes (PNS).Case presentation: In this case report, we described a 64-year-old patient with cutaneous metastasis GIST accompanied by nephrotic syndrome as PNS, in whom symptomatic treatment was ineffective, but clinical remission was achieved after surgery. Moreover, the patient has a missense mutation of NPHP4 . NPHP4 served as a negative regulator of the Hippo pathway. Hippo signaling pathway is involved in the development and progression of FSGS. NPHP4 is also indeed a driving force for proliferation in tumor cells. Therefore, the mutation of NPHP4 in this patient could explain the occurrence of GIST and FSGS and this was therefore not a random association.Conclusions: This is the first reported case of a GIST with cutaneous metastasis accompanied by nephrotic syndrome as PNS.
A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans (2022)

Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whereas the activity and stability are unaffected by the amino acid substitution, the ancestral enzyme produces more reactive oxygen species and increases cellular levels of transcripts encoding cytokines. We furthermore show that the ancestral enzyme has been reintroduced into the modern human gene pool by gene flow from Neanderthals and is associated with multiple traits in present-day people, including increased susceptibility for inflammatory-associated disorders and vascular disease.
Painting the near surface using geology, geophysics, and satellites (2009)

Abstract A smooth interpolation of a sparse uphole survey may be the main tool available for modeling the near surface in desert areas. An uphole survey does not properly define sharp, near-surface velocity changes associated with lithologic and topographic variations such as cliffs, canyons, or outcrops, which may be delineated by satellite imagery instead. We present a patchy interpolation technique to build a consistent near-surface model. The algorithm is based on K-means clustering to integrate geological, geophysical, and remote-sensing information. A somewhat arbitrary aspect of the method is the choice of how many clusters are used in segregating the data. Linking this parameter to surface geologic formations may be inadequate because P- or S-wave velocities are unlikely to have a sufficiently unique correlation with geologic age and lithology. We suggest an empirical criterion: improvement in the seismic stack section achieved by processing with parameters derived by various clustering choices and data-type combinations. This approach was tested using field data from Saudi Arabia.
Velocity-Aware Geo-Indistinguishability (2023)

Location Privacy-Preserving Mechanisms (LPPMs) have been proposed to mitigate the risks of privacy disclosure yielded from location sharing. However, due to the nature of this type of data, spatio-temporal correlations can be leveraged by an adversary to extenuate the protections. Moreover, the application of LPPMs at collection time has been limited due to the difficulty in configuring the parameters and in understanding their impact on the privacy level by the end-user. In this work we adopt the velocity of the user and the frequency of reports as a metric for the correlation between location reports. Based on such metric we propose a generalization of Geo-Indistinguishability denoted Velocity-Aware Geo-Indistinguishability (VA-GI). We define a VA-GI LPPM that provides an automatic and dynamic trade-off between privacy and utility according to the velocity of the user and the frequency of reports. This adaptability can be tuned for general use, by using city or country-wide data, or for specific user profiles, thus warranting fine-grained tuning for users or environments. Our results using vehicular trajectory data show that VA-GI achieves a dynamic trade-off between privacy and utility that outperforms previous works. Additionally, by using a Gaussian distribution as estimation for the distribution of the velocities, we provide a methodology for configuring our proposed LPPM without the need for mobility data. This approach provides the required privacy-utility adaptability while also simplifying its configuration and general application in different contexts.
Volatile Composition of Four Southern Highbush Blueberry Cultivars and Effect of Growing Location and Harvest Date (2011)

The volatile composition of four southern highbush blueberry cultivars ('Primadonna', 'Jewel', 'Snowchaser', and 'FL02-40') grown in two locations (Gainesville and Haines City, FL) and harvested multiple times was investigated. A total of 42 volatiles were identified, including 8 esters, 12 terpenoids, 11 aldehydes, 7 alcohols, and 4 ketones. Twelve of these volatiles are reported for the first time in highbush blueberries, with 10 being positively identified: (Z)-3-hexenal, (E,E)-2,4-hexadienal, (E,Z)-2,6-nonadienal, (E,E)-2,4-nonedienal, methyl 2-methylbutanoate, butyl acetate, 2-methylbutyl acetate, and geranyl acetate. The dominant volatiles were aldehydes followed by terpenoids and esters, with distinct varietal profiles. 'Primadonna' was characterized by a large amount of esters and C-6 aldehydes. In contrast, fewer than 4 esters were found in 'FL02-40' and 'Snowchaser', respectively, but they produced more terpenoids than 'Primadonna' and 'Jewel'. Location and/or harvest date affected the production of volatiles in 'Primadonna', but not so much in the other cultivars.
A user interface for a knowledge-based planning and scheduling system (1988)

The objective of EMPRESS (expert mission planning and replanning scheduling system) is to support the planning and scheduling required to prepare science and application payloads for flight aboard the US Space Shuttle. EMPRESS was designed and implemented in Zetalisp on a 3600 series Symbolics LISP machine. Initially, EMPRESS was built as a concept demonstration system. The system has since been modified and expanded to ensure that the data have integrity. Issues underlying the design and development of the EMPRESS-I interface, results from a system usability assessment, and consequent modifications are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
COUNTERMEASURES TO THE EFFECTS OF GRAVITY ON THE SKULLS OF HUMAN INFANTS. (2007)

The effects of altered gravity on the skeleton have been studied primarily in weight-bearing bones, so few gravitational biologists know of gravity’s role in shaping the skulls of human infants. Skull deformations due to prolonged exposure to the g vector in one direction are well-known to craniofacial experts, and the 30 fold increase in deformational positional plagiocephaly (PP) since 1992 demonstrates the need for increased public awareness in this area. In 1992, the American Academy of Pediatrics’ “Back to Sleep” campaign urged parents to place sleeping infants on their backs to prevent Sudden Infant Death Syndrome. The incidence of SIDS decreased by 45%, but craniofacial centers were inundated with parents seeking treatment for children with misshapen skulls. These distortions (brachycephaly, a flattened skull back, and PP, a parallelogram shaped skull in top view) are due to the force of gravity acting on the infant’s skull when the child is supine. Countermeasures include repositioning the infant for sleeping and increased tummy time, in which the infant is placed prone under parental supervision. The prone position encourages head raising, thus strengthening the neck muscles. Simple countermeasures are not always successful in skull re-shaping, and in these cases a molding helmet is used to offset the effects of gravity. Recent post-treatment studies at UTDB found that all improvements were not retained, particularly in the cranial base region, and that the distortions seen in the infant, e.g. a deviated chin and a forward ear placement, remain, and may cause orthodontic problems. Learning disabilities and other disorders are associated with PP. The huge increase in PP demonstrates an urgent need for education of parents and other caregivers about the effect of gravity on their child’s skull, and of the need for countermeasures to gravitational effects—in particular, supervised tummy time, and repositioning during sleep. Supported by UTDB Dept of Orthodontics.
Noise exposure in the general audience of a Formula 1 race (2014)

Formula 1 cars have a reputation for being among the loudest race cars. As such, noise exposure should be a major concern for not only drivers, crew and staff, but also audience members. Calibrated acoustic measurements were taken at multiple general admission areas at a Formula 1 race. Analysis of these measurements show that the exposure exceeded multiple standards for daily noise exposure limits within a fraction of the race. This presentation predicts the total noise exposure experienced at different track positions and what noise reduction rating would be required in order to reduce the exposure to safe levels. [This work was supported by Brüel & Kjær.]
On-line measurement of the thickness and optical quality of float glass with a sensor based on a diffractive element (2001)

An on-line apparatus for accurate measurement of float-glass thickness and edge distortion was built and tested in industrial environments. The intelligent part of the sensor is a diffractive optical element. The theory and construction of the apparatus are described, and data from on-line measurements are presented.
A New Method of Measuring Glucose-forming Activity in Rice Koji (1996)

A new method for measuring glucose-forming activity in rice koji is proposed. In this method, G 2-PNP (4-nitrophenyl O-α-D glucopyranosyl-(1-4)-β-D- glucopyranoside) is used as the substrate. Because both glucoamylase and a-glucosidase can hydrolyze the substrate, the results showed the sum total of these enzymes activities (that is, glucose-forming activity) in rice koji extract. The substrateis hydrolyzed by these enzymes and the resulted product (PNP) is measured to determine the amount of glucose-forming activity quantitatively. This method has the following advantages:(i) The presence of glucose in the sample does not influence the results of the measurement, and therefore there is no need to dialyze the rice koji extract prior to analysis.(ii)α-Amylase of Aspergillus oryzae in the sample does not affect the results of measurement because if cannot hydrolyze the substrate.(iii) The assay procedure is simple, and can be easily accomplished in a short time. The proposed method showed good correlation with the method generally used for glucoamylase assay when purified glucoamylase is used as a sample. The averages of recovery of glucoamylase and a-glucosidase added were 99.6% and 101.1%, respectively. Coefficients of variation in within-day and day-to-day experiments were within 1% and 2.8.%, respectively.
THE COENZYME FUNCTION OF THIAMINE PYROPHOSPHATE IN PENTOSE PHOSPHATE METABOLISM (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE COENZYME FUNCTION OF THIAMINE PYROPHOSPHATE IN PENTOSE PHOSPHATE METABOLISMB. L. Horecker and P. Z. SmyrniotisCite this: J. Am. Chem. Soc. 1953, 75, 4, 1009–1010Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://pubs.acs.org/doi/10.1021/ja01100a525https://doi.org/10.1021/ja01100a525research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations160LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts