gebhart/patrepeval huggingface dataset:
A Distributed Image-Database Architecture for Efficient Insertion and Retrieval (1999)

Allowing for content-based image retrieval, an image database must perform a number of time-consuming feature extraction tasks when inserting a new image, when searching with a newly entered image, or when bulk-loading many images in parallel. The duration of this preprocessing step typically lies far beyond what one would accept for conventional (short-running) database transactions. Hence, a natural step is to export the extraction tasks from the database and to distribute them among a number of external components in a cluster. As a consequence the database plays the role of a coordinator that assigns tasks to &amp;quot;its&amp;quot; auxiliary components. Since the execution times for feature extraction and the availabilities of such components vary over time, the coordinator needs additional information about the components in order to &amp;quot;optimally&amp;quot; assign extraction tasks to available components such that the overall preprocessing cost is minimized. At the same time, similarity search should be suppo...
Zero Temperature Coefficient Surface-Acoustic-Wave Devices Using Epitaxial AlN Films (1982)

Until now, very few papers have appeared on the temperature coefficient of delay (TCD) for surface acoustic waves (SAW) on A1N films. We report that A1N has a negative TCD of \-30 ppm/C, and that the A1N layer of appropriate thickness cancels the first-order temperature coefficient for sapphire and silicon. A1N films on sapphire substrates. A1N films were single-crystal films grown by metalorganic chemical vapor deposition. The experimental value of TCD at 25OC decreased with increasing kH (k: wave number, H; thickness of A1N film). With the (0001)AlNl (0001) [1100]~1~0~.structure a zero temperature COefficient SAW oscillator of 1.139 GHz was obtained at kH-b3.75, and with the (1120) [0001]A1N/(01~2) [0I11]Al2O3 structure a negative TCD (-7.5 ppm/'C) was obtained at kHn,3.0. Next, by computer fitting, we have determined the first-order temperature COefficients of elastic constants of AlN, and then calculated all the zero TCD characteristics of A1N/A1203, AlN/Si, AlN/SOS and A1N/Si02/Si combinations. We have measured the TCD's for
Parental Report of Health Conditions and Health Care Use Among Children With and Without Autism (2006)

We found markedly higher reports of concurrent conditions and health care use associated with childhood autism in this study.
Mechanism of Liquid Chromatography of Macromolecules under Limiting Conditions of Adsorption (1999)

Abstract A mechanistic study of liquid chromatography under limiting conditions of adsorption (LC LCA) is presented. Polystyrene was evaluated in a THF/n-hexane binary eluent using wide- and narrow-pore silica gels and styrene divinylbenzene-based sorbents. The LCA condition was achieved though a balance between the free energies of exclusion and adsorption. Polymer solubility does not influence the retention volume, with LC LCA occurring in the soluble domain of the cloud point diagram. The molecular weight independent retention (LCA) was not found to significantly vary with the mobile phase flow rate, volume and concentration injected. However, the LCA was strongly influenced by the stationary phase surface chemistry and pore size, as well as the temperature. The limiting conditions of adsorption are, therefore, relatively robust for a given poly-mer-eluent-sorbent combination and depend on the operating and physical characteristics of the chromatograph- Examples of LCLCA conditions are reported herein.
Scotch (2020)

Sketching algorithms are a powerful tool for single-pass data summarization. Their numerous applications include approximate query processing, machine learning, and large-scale network monitoring. In the presence of high-bandwidth interconnects or in-memory data, the throughput of summary maintenance over input data becomes the bottleneck. While FPGAs have shown admirable throughput and energy-efficiency for data processing tasks, developing FPGA accelerators requires a sophisticated hardware design and expensive manual tuning by an expert. We propose Scotch, a novel system for accelerating sketch maintenance using FPGAs. Scotch provides a domain-specific language for the user-friendly, high-level definition of a broad class of sketching algorithms. A code generator performs the heavy-lifting of hardware description, while an auto-tuning algorithm optimizes the summary size. Our evaluation shows that FPGA accelerators generated by Scotch outperform CPU- and GPU-based sketching by up to two orders of magnitude in terms of throughput and up to a factor of five in terms of energy efficiency.
Group II intron domain 5 facilitates a trans-splicing reaction. (1988)

A self-splicing group II intron of yeast mitochondrial DNA (aI5g) was divided within intron domain 4 to yield two RNAs that trans-spliced in vitro with associated trans-branching of excised intron fragments. Reformation of the domain 4 secondary structure was not necessary for the trans reaction, since domain 4 sequences were shown to be dispensable. Instead, the trans reaction depended on a previously unpredicted interaction between intron domain 5, the most highly conserved region of group II introns, and another region of the RNA. Domain 5 was shown to be essential for cleavage at the 5' splice site. It stimulated that cleavage when supplied as a trans-acting RNA containing only 42 nucleotides of intron sequence. The relevance of our findings to in vivo trans-splicing mechanisms is discussed.
Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichment (2005)

A new liquid formulation of ursodeoxycholic acid suitable for paediatric patients is pharmacologically bioequivalent to capsules when given as single, or repeated oral doses.
A new genus of tortricid moths (Tortricidae: Euliini) injurious to grapes and stone fruits in Chile (2000)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Fiber decomposition of deterministic reaction networks with applications (2021)

Deterministic reaction networks (RNs) are tools to model diverse biological phenomena characterized by particle systems, when there are abundant number of particles. Examples include but are not limited to biochemistry, molecular biology, genetics, epidemiology, and social sciences. In this chapter we propose a new type of decomposition of RNs, called fiber decomposition. Using this decomposition, we establish lifting of mass-action RNs preserving stationary properties, including multistationarity and absolute concentration robustness. Such lifting scheme is simple and explicit which imposes little restriction on the reaction networks. We provide examples to illustrate how this lifting can be used to construct RNs preserving certain dynamical properties.
Effect of alpha-protein kinase C neutralizing antibodies and the pseudosubstrate peptide on phosphorylation, migration, and growth of REF52 cells. (1993)

REF52 cells are a line of rat embryo fibroblasts that express alpha-, delta-, epsilon-, and zeta-protein kinase Cs (PKCs). In this report, we have used neutralizing antibodies to alpha-PKC to study the role of this specific PKC isozyme in REF52 cell functions. Effects of the more general PKC inhibitor, the pseudosubstrate peptide, were also studied. Previous work demonstrated that alpha-PKC is concentrated in focal contacts of REF52 cells (Jaken, S., Leach, K., and Klauck, T. J. Cell Biol., 109: 697-704, 1989). alpha-PKC redistributed to the leading lamellopodia of cells stimulated to migrate into an artificial wound, indicating that alpha-PKC activation may be coupled to migratory stimuli. The effects of the alpha-PKC neutralizing antibodies and the pseudosubstrate peptide on responses associated with focal contact functions, namely attachment, migration, and growth, were studied. The data demonstrate that the antibodies and the pseudosubstrate peptide were all efficient inhibitors of phorbol ester-stimulated phosphorylation. However, only the pseudosubstrate peptide efficiently inhibited the migration and growth responses necessary to repopulate an artificial wound. These results indicate that PKCs, but probably not alpha-PKC in particular, are important in these responses. However, because the neutralizing antibodies did not completely inhibit phorbol 12,13-dibutyrate-stimulated phosphorylation, a potential role for alpha-PKC in migration and growth cannot be excluded.
RFLP of rRNA genes and sequencing of the 16S-23S rDNA intergenic spacer region of ammonia-oxidizing bacteria: a phylogenetic approach (1999)

It has been established that 16S rRNA gene-based phylogeny gives a low resolution between members of the chemoautotrophic ammonia-oxidizing bacteria (AOB) belonging to the beta-subclass of the Proteobacteria. In this study, 12 isolates of AOB were ribotyped, and the sequences of the 16S-23S rDNA intergenic spacer region (ISR) were determined and used in a phylogenetic study. 16S and 23S rDNA ribotyping revealed that the AOB studied contain only one rrn operon per genome, in contrast to most bacteria, which have 5-10 copies of the rRNA genes per genome. It is likely that the presence of only one set of rRNA genes is related to the slow growth of the AOB. The 16S and 23S rRNA genes of the AOB were shown to be arranged in the classical way: a 16S rRNA gene, an ISR and a 23S rRNA gene. Despite the close phylogenetic relationship among the AOB, the relative location of the rRNA genes in the genome appears to vary considerably. The size of the ISR was approximately 400 bp in the Nitrosomonas isolates and 645-694 bp in the Nitrosospira isolates, suggesting a species-specific size difference in the ISR. The ISR contained two potential tRNA genes in the 5' end in all isolates studied. The similarity values between the ISR sequences of the AOB are low (42.9-96.2%) compared with the 16S rDNA sequence similarity values, and therefore the ISR sequences are valuable as a complementary phylogenetic tool in combination with 16S rRNA gene sequences. The phylogenetic analysis of the AOB based on ISR sequences confirms the 16S rRNA gene-based phylogeny but has the benefit of giving a higher resolution.
A unique thymus-derived regulatory T cell subset associated with systemic lupus erythematosus (2020)

A unique tTreg subset with dichotomic immunoregulatory and T helper 17 phenotypes is increased in the circulation of SLE patients and may be involved in the pathogenic process of SLE.
Global Austerity and Local Democracy: The Case of Participatory Budgeting in Guelph, ON. (2017)

This paper examines the role of participatory budgeting in policy-making at the municipal level, through a case study of the longest experiment with participatory budgeting in Canada, the Neighbourhood Support Coalition (NSC) in Guelph, ON. While existing scholarship tends to view participatory budgeting largely as oppositional to neoliberalism, I argue that participatory budgeting in Guelph is better understood as an adaptation of community groups to a neoliberal political context, rather than a direct challenge to neoliberal policies. When participatory budgeting began to be perceived as contravening neoliberal rationalities of autonomy, self-sufficiency, and marketization, the grassroots democratic elements of the practice were ultimately sacrificed in favour of a process that fit better with these logics. This work builds on previous research on participatory budgeting in Guelph by both bringing participatory budgeting in explicit dialogue with neoliberalism, and temporally extending the narrative of Guelph’s experience with participatory budgeting beyond 2009.
Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. (2020)

Deregulation of fibroblast growth factor receptor (FGFR) signaling is tightly associated with numerous human malignancies, including cancer. Indeed, FGFR inhibitors are being tested as anti-tumor drugs in clinical trials. Among gliomas, FGFR3 fusions occur in IDH wild-type diffuse gliomas leading to high FGFR3 protein expression and both, FGFR3 and FGFR1, show elevated expression in aggressive ependymomas. The aim of this study was to uncover the expression of FGFR1 and FGFR3 proteins in choroid plexus tumors and to further characterize FGFR-related as well as other genetic alterations in FGFR3 expressing tumors. Expression levels of FGFR1 and FGFR3 were detected in 15 choroid plexus tumor tissues using immunohistochemistry of tissue microarrays and 6 samples were subjected to whole mount FGFR3 staining. Targeted sequencing was used for deeper molecular analysis of two FGFR3 positive cases. Moderate expression of FGFR1 or FGFR3 was evidenced in one third of the studied choroid plexus tumors. Targeted sequencing of a choroid plexus carcinoma and an atypical choroid plexus papilloma, both with moderate-to-strong FGFR3 expression, revealed lack of protein-altering mutations or fusions in FGFR1 or FGFR3, but TP53 was altered in both tumors. FGFR3 and FGFR1 proteins are expressed in a subpopulation of choroid plexus tumors. Further studies using larger cohorts of patients will allow identification of the clinicopathological implications of FGFR1 and FGFR3 expression in choroid plexus tumors.
Iscom (Immunostimulating Complex) Vaccines Containing Mono‐ or Polyvalent Pili of Enterotoxigenic E. coli; Immune Response of Rabbit and Swine (1990)

Iscom (immunostimulating complex) vaccines were prepared to contain K88ab, K88ac, K99 and 987P pili (fimbriae) of enterotoxigenic E. coli bacteria as monovalent or quadrivalent preparations. The iscoms injected into rabbits and into pigs elicited similar or higher immune response in both animal species than the oil adjuvanted vaccine containing about 5 times more of the same pilus protein. It is concluded that inclusion of pili into iscoms results in immunogenic preparations likely worth pursuing for vaccine production against enterotoxic colibacillosis of newborn pigs. The iscoms did not induce local reaction at the injection sites in contrast to the oil adjuvanted vaccines.
Positioning of carbon nanotubes using soft-lithography for electronics applications (2005)

Carbon nanotubes (CNTs) devices have been fabricated using two similar microfabrication processes involving poly(dimethylsiloxane) (PDMS) molecular stamping of 2-thiolpyridine and subsequent self-assembly of CNTs. The two methods allow the fabrication of CNT devices with &amp;gt;90% yield. From Vg=−5to+5V, when Ti–Au electrodes are fabricated on top of the self-assembled CNT films, our devices exhibit p-type field-dependent behavior. When the CNTs have been self-assembled across pre-defined Ti–Au electrodes, metallic conduction has been observed. The electronic properties of our back-gated CNT devices are found to depend upon CNT concentration in the original self-assembly solution. The final structure of the CNT device can affect the field dependency as a result of screening effects at the contact regions, with the 2-thiolpyridine acting as a further screening region.
Sustained Erythropoietin Production in Nephrectomized Rats Subjected to Severe Hypoxia (1973)

S ummary . The present studies indicate that rats of both sexes subjected to a hypoxic stimulus of severe degree (0.35 atmospheres of air) show sustained production of erythropoietin (Ep) up to 30 hr after bilateral nephrectomy. In contrast to this phenomenon, the Ep response to relatively mild hypoxia (0.45 atmospheres of air) declines rapidly and is totally abolished within either 12 hr (females) or 24 hr (males) after nephrectomy. In this regard, since orchidectomized rats and intact female animals show a similar decline of the Ep response curve, it seems likely that androgens play a major role in the above sex difference. The sustained Ep production in both anephric rodents exposed to severe hypoxia and ureter‐ligated rats subjected to mild hypoxic stimuli suggest that extrarenal Ep production is largely independent of the development of uraemia. It is postulated that the biogenesis of Ep in anephric rodents is mediated by either the triggering of extrarenal sources of Ep and/or erythrogenin (Eg) induced by severe hypoxia or activation of residual renal Eg following relatively mild hypoxic stimuli.
LOGOS: a modular Bayesian model for de novo motif detection (2004)

The complexity of the global organization and internal structures of motifs in higher eukaryotic organisms raises significant challenges for motif detection techniques. To achieve successful de novo motif detection it is necessary to model the complex dependencies within and among motifs and incorporate biological prior knowledge. In this paper, we present LOGOS, an integrated LOcal and GlObal motif Sequence model for biopolymer sequences, which provides a principled framework for developing, modularizing, extending and computing expressive motif models for complex biopolymer sequence analysis. LOGOS consists of two interacting submodels: HMDM, a local alignment model capturing biological prior knowledge and positional dependence within the motif local structure; and HMM, a global motif distribution model modeling frequencies and dependencies of motif occurrences. Model parameters can be fit using training motifs within an empirical Bayesian framework. A variational EM algorithm is developed for de novo motif detection. LOGOS improves over existing models that ignore biological priors and dependencies in motif structures and motif occurrences, and demonstrates superior performance on both semi-realistic test data and cis-regulatory sequences from yeast and Drosophila sequences with regard to sensitivity, specificity, flexibility and extensibility.
The Influence of Obesity on Health (1974)

Coronary Heart DiseaseKeys and his colleagues39 have discussed the evidence derived from their seven-nation study identifying obesity as a risk factor for coronary heart disease. They preferred the body-mass index (BMI = W/H2) as the index of obesity. Although blood pressure was significantly correlated with adiposity, the association was low. Cross-classification suggested a significant excess of coronary heart disease in the upper quartile of men classified as obese when blood pressure was ignored, but the effect of obesity disappeared when only normotensive men were considered. Using multivariate analysis, the authors could show no predictive value of body fatness . . .
NUMERICAL INVESTIGATIONS ON THE RESIDUAL CAPACITY AND ECONOMIC LOSSES OF EARTHQUAKE-DAMAGED REINFORCED CONCRETE WALL STRUCTURES (2021)

NUMERICAL INVESTIGATIONS ON THE RESIDUAL CAPACITY AND ECONOMIC LOSSES OF EARTHQUAKE-DAMAGED REINFORCED CONCRETE WALL STRUCTURES - 8th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering - 28-30 June 2021, Streamed from Athens, Greece
Stewardship Monitoring and Control of Aldicarb Application to Florida Citrus (2005)

Temik (aldicarb) is a nematicide that has been used widely in the Florida citrus industry asnematodes significantly reduce tree vigor, growth, and fruit productivity. However, concerns aboutgroundwater contamination have led to regulations requiring a 91.4 m (300 ft) buffer around all potable waterwells and a 304.8 m (1000 ft) buffer for wells in highly vulnerable soils. To provide documentation of properapplication, two DGPS-based approaches were considered for implementation on current pneumatic drygranular applicator units. The first was a black-box DGPS/system status data logger. A second level systemwas developed for data logging and control through a hand-held pocket PC using Farmworks variable ratetechnology (VRT) software. Electronic sensors, interfacing, and signal conditioning were incorporated into apneumatic discharge granular applicator unit to demonstrate these technologies for both ground wheel drivenand PWM (pulse width modulation) motor-based dispensing. The DGPS unit used for both applications was awide area augmentation system (WAAS) corrected Trimble 106 antenna. Additional sensors wereimplemented for measuring material discharge rates and ground speed for PWM control. Performance data,logged at 1 Hz for both systems and a general error analysis, are presented. Factors, such as well-spottingaccuracy and product delivery times, are included.
Mise en évidence d'un nouveau type de chaînes ferrimagnétiques dans les fluorures de type jarlite Ba7MnFe6F34 et Ba7FeFe6F34 (1989)

Les composes du titre cristallisent dans le systeme monoclinique avec le groupe d'espace C2/m. Etude de la variation thermique de la susceptibilite magnetique
Hitting KRAS When It’s Down (2020)

KRAS, one of the most prevalent oncogenes and sought-after anticancer targets, has eluded chemists for decades until an irreversible covalent strategy targeting a specific mutation (G12C) paved the way for the first KRAS inhibitors to reach the clinic. <b>MRTX849</b> is one such clinical candidate with promising initial results in patients harboring the mutation. The impressive optimization story of <b>MRTX849</b> highlights challenges and solutions in the development of covalent drugs, including the use of an α-fluoroacrylamide electrophile.
Importance of autophosphorylation at Ser186 in the A‐loop of salt inducible kinase 1 for its sustained kinase activity (2008)

Autophosphorylation is an important mechanism by which protein kinases regulate their own biological activities. Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features autophosphorylation activity. We provide evidence that Ser186 in the activation loop is the site of autophosphorylation and essential for the kinase activity. Ser186 is located at the +4 position of the critical Thr residue Thr182, which is phosphorylated by upstream kinases such as LKB1. The relationship between phosphorylation at Ser186 and at Thr182 in COS-7 cells indicates that the former is a prerequisite for the latter. Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates Ser/Thr residues located at the fourth position ahead of the pre-phosphorylated Ser/Thr residues, and inhibitors of GSK-3beta reduce the phosphorylation at Thr182. The results of an in vitro reconstitution assay also indicate that GSK-3beta could be the SIK1 kinase. However, overexpression and knockdown of GSK-3beta in LKB1-defective HeLa cells suggests that GSK-3beta alone may not be able to phosphorylate or activate SIK1, indicating that LKB1 may play a crucial role by phosphorylating SIK1 at Thr182, possibly as an initiator of the autophosphorylation cascade, and GSK-3beta may phosphorylate SIK1 at Thr182 by recognizing the priming-autophosphorylation at Ser186 in cultured cells. This may also be the case for the other isoform SIK2, but not for SIK3.