gebhart/patrepeval huggingface dataset:
Adherence to the Mediterranean Diet and Inflammatory Markers (2018)

The aim was to assess inflammatory markers among adults and adolescents in relation to the adherence to the Mediterranean diet. A random sample (219 males and 379 females) of the Balearic Islands population (12-65 years) was anthropometrically measured and provided a blood sample to determine biomarkers of inflammation. Dietary habits were assessed and the adherence to the Mediterranean dietary pattern calculated. The prevalence of metabolic syndrome increased with age in both sexes. The adherence to the Mediterranean diet in adolescent males was 51.3% and 45.7% in adults, whereas in females 53.1% and 44.3%, respectively. In males, higher adherence to the Mediterranean diet was associated with higher levels of adiponectin and lower levels of leptin, tumor necrosis factor alpha (TNF-α), plasminogen activator inhibitor 1 (PAI-1) and high-sensitivity C-reactive protein (hs-CRP) in adults, but not in young subjects. In females, higher adherence was associated with lower levels of leptin in the young group, PAI-1 in adults and hs-CRP in both groups. With increasing age in both sexes, metabolic syndrome increases, but the adherence to the Mediterranean diet decreases. Low adherence to the Mediterranean dietary pattern (MDP) is directly associated with a worse profile of plasmatic inflammation markers.
Improved predictions of the physical properties of Zn- and Cd-based wide\n band-gap semiconductors: a validation of the ACBN0 functional (2015)

We study the physical properties of Zn$X$ ($X$=O, S, Se, Te) and Cd$X$\n($X$=O, S, Se, Te) in the zinc-blende, rock-salt, and wurtzite structures using\nthe recently developed fully $ab$ $initio$ pseudo-hybrid Hubbard density\nfunctional ACBN0. We find that both the electronic and vibrational properties\nof these wide-band gap semiconductors are systematically improved over the PBE\nvalues and reproduce closely the experimental measurements. Similar accuracy is\nfound for the structural parameters, especially the bulk modulus. ACBN0 results\ncompare well with hybrid functional calculations at a fraction of the\ncomputational cost.\n
Automated Analysis of X-Ray Spectrum Images from the SEM: A Practical New Tool for Microanalysis (2001)

Abstract It is a conundrum that faces microanalysts every day: how do you comprehensively survey the chemistry of a microstructure in a reasonable time? Traditional solutions in the SEM would include taking an image and then collecting x-ray spectra from a series of points. This method relies heavily on the operator’s ability to identify chemically distinct regions. in addition, for a complex microstructure, this could take a considerable amount of time to do correctly. On the positive side, if care is taken, these ‘point spectra’ can be readily quantified. An alternative method that has been used widely is x-ray mapping, where a window of intensity in the spectra is integrated and displayed as an image. This has the advantage that qualitative elemental distributions from an area of a microstructure can be visualized. The disadvantages are that maps are generally not quantitative, can be susceptible to artifacts, and rely on fore knowledge of the elements to map.
β- and γ-Amino Acids at α-Helical Interfaces: Toward the Formation of Highly Stable Foldameric Coiled Coils (2014)

Since peptides are vital for cellular and pathogenic processes, much effort has been put into the design of unnatural oligomers that mimic natural peptide structures, also referred to as foldamers. However, to enable the specific application of foldamers, a thorough characterization of their interaction profiles in native protein environments is required. We report here the application of phage display for the identification of suitable helical environments for a sequence comprising an alternating set of β- and γ-amino acids. In vitro selected sequences show that an increase in the hydrophobic surface area at the helical interface as well as the incorporation of a polar H-bond donor functionality can significantly improve interhelical interactions involving backbone-extended amino acids. Thus, our data provide insight into the principles of the rational design of foldameric inhibitors for protein-protein interactions.
The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases (2005)

Modulation of aberrant cell cycle regulation is a potential therapeutic strategy applicable to a wide range of tumor types. JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro. In human cancer cells, treatment with JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation. At low concentrations, JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Inhibition of CDK1 kinase activity, altered CDK1 phosphorylation status, and interference with downstream substrates such as retinoblastoma were also shown in human tumor cells following drug treatment. Flow cytometric analysis of DNA content showed that JNJ-7706621 delayed progression through G1 and arrested the cell cycle at the G2-M phase. Additional cellular effects due to inhibition of Aurora kinases included endoreduplication and inhibition of histone H3 phosphorylation. In a human tumor xenograft model, several intermittent dosing schedules were identified that produced significant antitumor activity. There was a direct correlation between total cumulative dose given and antitumor effect regardless of the dosing schedule. These results show the therapeutic potential of this novel cell cycle inhibitor and support clinical evaluation of JNJ-7706621.
VIABLE YIELD OF ISLETS FROM ISCHEMIC PORCINE PANCREATA IS IMPROVED USING TWENTY-FOUR HOUR HYPOTHERMIC MACHINE PERFUSION PRESERVATION. (2008)

1Cell and Tissue Systems, N. Charleston, SC, USA, 2Organ Recovery Systems, Des Plaines, IL, USA. 3Dept. Surgery, Medical University of South Carolina, Charleston, SC. USA.
Optimization of Active Queue Management based on Proportional Control System (2004)

This paper shows the design and performance of an AQM (Active Queue Management) enabled router. The design is based on a classical proportional control system. The application of such a router is to enhance streaming media over IP performance by avoiding bursty packet drop situations, control the router queue delay, and balancing packet drop, delay, and link utilization. The selected AQM equilibrium point limits the average package delay to the selected value, which is of great importance for real-time applications. It also limits the delay jitter. The AQM performance was optimized by adjusting the proportional gain, searching for lowest possible packet drop probability when the node was 100 % loaded by aggregated IP traffic (modelled as n.e.d. traffic). The results show that at 100 % traffic load the packet loss probability can be kept as low as 0.57 % and output link utilization at 99.4%. An alternative gain setting with better stability performance at high overload shows only slightly other results at the same load (0.69 % drop and 99.3 % link utilization).
EMG-triggered stimulation post spinal cord injury: A case report (2017)

Neurophysiological evaluation can be useful in identifying residual function below the level of injury, which can, in turn, be enhanced through appropriate rehabilitation strategies.
The Reaction of Diethanolamine with 2-Chloronitrobenzene-A Reinvestigation (1985)

Abstract In a report on the reaction of 2-chloronitrobenzene (1) with diethanolamine (2), Meltsner et al 1 claim that the expected SNAr product, N-(2-nitrophenyl)diethanolamine (3), is not formed; rather that the products are 2,2′-dichloroazobenzene (4), 2-nitrophenol (5), 2-chloroaniline (6) and 4-(2-aminophenyl)morpholine (7). Similar products in which the nitro function is reduced are also reported2 for the corresponding reaction with ethanolamine. In this laboratory, in an attempted preparation of 2,2′-dichloroazobenzene (4) for reference purposes in photochemical studies on the antineoplastic agent 5-(3-azido-4-chlorophenyl)-6-ethyl-pyrimidin-2,4-diamine3, the expected SNAr product (3) was obtained along with other products.
E110 Alloy Cladding Tube Properties and Their Interrelation with Alloy Structure-Phase Condition and Impurity Content (2000)

The E110 alloy (Zr-1Nb) designed in Russia has been in successful operation in the VVER and RBMK reactors since 1960. The evolution of the Russian reactors during this period of time, their numbers and operating parameters, and, hence, the relevant production of the cladding tubes required much effort from the researchers and producers to optimize the technological processes resulting in the high operating reliability of the fuel rods clad in the E110 alloy. In the Zr-Nb system to which the E110 alloy pertains, highly sophisticated structure-phase transformations proceed depending on the temperature-rate conditions of processing and the impurity content of the alloy. The alloy structure formed during its processing affects substantially the processability and performance of semi-products and finished tubes. The paper demonstrates the interrelation between the structure-phase transformations of the E110 alloy and the temperature-rate conditions of processing as well as the oxygen content of the alloy. The phase composition and microstructure are shown to play an essential part in providing the tubes with the requisite properties and their stability. The properties of cladding tubes having different structures and fuel rod claddings as in-pile irradiated are analyzed. The corrosion behavior of E110 alloy claddings is shown to be strongly dependent upon the material structure and reactor operating conditions.
Infiltration of Natural Caries Lesions in Relation to Their Activity Status and Acid Pretreatment in vitro (2012)

This study aimed at testing how active and inactive enamel caries lesions differ by their degree of resin infiltration, and whether the choice of acid pretreatment plays a crucial role. Four examiners assessed 104 human molars and premolars with noncavitated enamel lesions and classified them as 'active' or 'inactive' using the Nyvad criteria. Forty-five teeth were included in this study after independent unanimous lesion activity assessment. Lesions were cut perpendicularly into 2 halves. Each half lesion was pretreated with either 15% hydrochloric acid or 35% phosphoric acid. The lesions were infiltrated after staining with rhodamine isothiocyanate. Thin sections of 100 µm were prepared and the specimens were bleached with 30% hydrogen peroxide. The specimens were then counterstained with sodium fluorescein, subjected to confocal laser scanning microscopy and analyzed quantitatively. Outcome parameters were maximum and average infiltration depths as well as relative penetration depths and areas. In active lesions no significant difference of percentage maximum penetration depth and percentage average penetration depth between lesions pretreated with hydrochloric or phosphoric acid could be observed. In inactive lesions, however, phosphoric acid pretreatment resulted in significantly lower penetration compared to hydrochloric acid pretreatment. Surface conditioning with hydrochloric acid led to similar infiltration results in active and inactive lesions. Moreover, inactive lesions showed greater variability in all assessed infiltration parameters than did active lesions. In conclusion, caries lesion activity and acid pretreatment both influenced the infiltration. The use of phosphoric acid to increase permeability of the surface layer of active lesions should be further explored.
ChemInform Abstract: Use of Primary Amines for the Selective N‐Alkylation of Anilines by a Reusable Heterogeneous Catalyst. (2014)

Abstract A simple protocol for the Pd‐C mediated oxidation of primary amines to imines followed by aniline addition is developed.
Photoinduced charge-transfer dissociation in van der Waals complexes. V. Na⋯XCH3 (X=F, Cl, and Br) (1997)

van der Waals complexes Na⋯XCH3 (X=F, Cl, and Br) have been generated by crossing a beam of sodium with the expansion region of a supersonic jet of the appropriate halide, seeded with a rare gas. The identity of these complexes was determined by photoionization time-of-flight mass spectrometry. The primary route for photodepletion of these complexes is thought to be the excitation of the Na chromophore followed by a charge-transfer dissociation: Na⋯XCH3+hν→[Na*⋯XCH3]‡→[Na+⋯XCH3−]‡→NaX+CH3. Measurement of the photo-depletion cross section as a function of the excitation wavelength provided an approach to the study of these harpooning reactions starting in selected transition states. The action spectra for the three complexes consisted of up to four broad peaks. An assignment, made by ab initio calculations, was based on the electronically excited states of Na* perturbed by the halide molecule in the complex. Peaks, ranging from the red (∼700 nm) to the blue (∼400 nm), were assigned to a superposition of Na* states 3 2Px,y, and to successively higher excited states 3 2Pz, 4 2S, and 3 2D. The transition probabilities computed for the various Na⋯XCH3→[Na*⋯XCH3]‡ transitions were generally in qualitative accord with experiment. Vibrational progressions of the covalent excited states 3 2Px,y,z were observed and analyzed.
Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1 (2023)

Abstract Poxviruses are large double-stranded DNA viruses that infect a wide range of animals including humans. Since the eradication of smallpox, other members of the poxvirus family, such as monkeypox virus (MPXV) are still posing a great threat to public health. Vaccinia virus (VACV) is a prototypic poxvirus used as the vaccine strain for smallpox eradication. VACV encodes a serine protease inhibitor 1 (SPI-1) conserved in all orthopoxviruses, which has been recognized as a host range factor for modified vaccinia virus Ankara (MVA), an approved smallpox vaccine and a promising vaccine vector. FAM111A, a nuclear protein that regulates host DNA replication, was shown to restrict the replication of VACV-ΔSPI-1 in human cells. Nevertheless, the detailed antiviral mechanisms of FAM111A were unresolved. Here, we show that FAM111A is a potent restriction factor for VACV-ΔSPI-1 and MVA. Deletion of FAM111A rescued the replication of MVA and VACV-ΔSPI-1 and overexpression of FAM111A significantly reduced viral DNA replication and virus titers but did not affect viral early gene expression. The antiviral effect of FAM111A necessitated its trypsin-like protease domain and DNA binding domain but not the PCNA-interacting motif. We further discovered that FAM111A translocated into the cytoplasm upon VACV infection and this process was mediated by the cGAS-STING signaling pathway. Infection-triggered FAM111A degraded the nuclear pore complex via its protease activity, translocated to the cytoplasm, and interacted with and promoted the degradation of virus DNA binding protein I3 in a DNA-dependent manner. Interestingly, the protease activity of FAM111A was only needed for nuclear export but not I3 degradation as further analysis showed I3 was degraded through autophagy. Moreover, VACV SPI-1 was found primarily in the nucleus of infected cells and antagonized FAM111A by prohibiting its nuclear export. MPXV and lumpy skin disease virus SPI-1s also inhibited human FAM111A. Our findings reveal the detailed mechanism by which FAM111A functions to restrict a cytoplasmic DNA virus and provide explanations for the immune evasive function of VACV SPI-1.
Vibrational Study of Organometallic Complexes with Thiophene Ligands:  Models for Adsorbed Thiophene on Hydrodesulfurization Catalysts (2001)

Interpretation and comparison of the vibrational spectra of organometallic complexes containing thiophene ligands with IR spectra of adsorbed thiophene on sulfided Mo/Al2O3 catalysts have permitted a definitive assignment of the adsorption mode of the surface-bonded thiophene. Infrared and Raman spectra were acquired for three organometallic complexes: (η5-C5D5)Re(CO)2(η1(S)-C4H4S), (η5-C4H4S)Cr(CO)3, and [(η5-C4H4S)Mn(CO)3]BF4. The vibrational properties of η1(S)- and η5-coordinated thiophene were further investigated through normal-mode analyses of the IR spectra of thiophene coordinated in (η5-C4H4S)Cr(CO)3 and (η5-C5D5)Re(CO)2(η1(S)-C4H4S). Perturbations among the force constants of a gas-phase thiophene model, consistent with the structure of η1(S)- and η5-coordinated thiophene ligands, gave rise to respective thiophene force fields that allowed for the accurate determination of the IR spectra of thiophene coordinated in the Cr and Re complexes. Spectral shifts observed for the IR spectrum of the η1(S)-coordinated thiophene ligand, with respect to the IR spectrum of free thiophene, are similar to those observed for analogous bands of thiophene adsorbed at the surface of sulfided Mo/Al2O3 catalysts. Furthermore, perturbations among the force constants of η1(S)-coordinated thiophene, necessary to model such shifts, indicate that the hydrocarbon backbone of thiophene is strengthened upon η1(S) adsorption, whereas the C−S bonds are significantly weakened. These bonding changes, along with the assignment of the adsorption mode of thiophene, suggest an HDS mechanism in which the initial steps are η1(S) adsorption of thiophene followed by subsequent cleavage of one of the C−S bonds.
Enhancement of CO2 and H2 Uptake for the Production of Biodiesel in Cupriavidus Necator (2012)

Cupriavidus necator fixes CO{sub 2} through the Calvin-Benson-Bassham (CBB) cycle using electrons and energy obtained from the oxidation of H{sub 2}. Producing biodiesel-equivalent electrofuel from renewable CO{sub 2} and H{sub 2} has immense potential, especially if the fuel is compatible with the existing fuel infrastructure. This research addressed enhanced substrate utilization by focusing on two strategies: (1) optimizing transcriptional regulations to afford over-expression of Ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO), the enzyme responsible for assimilation of CO{sub 2} into the CBB cycle; and (2) hydrogenase over-expression by introduction of additional copies of genes encoding a membrane-bound hydrogenase (MBH), a soluble hydrogenase (SH), and their maturation machinery to enhance oxidation of H{sub 2} to generate NAD(P)H and ATP required for CO{sub 2} fixation. Incorporation of these strategies into a single production strain resulted in 6-fold CO{sub 2} and 3-fold H{sub 2} uptake improvement, in vitro, with the overarching goal of providing abundant reducing equivalents towards the economic production of biodiesel in C. necator.
Effects of mutual coupling on super-resolution DF in linear arrays (1992)

The traditional narrowband array signal processing model is expanded by incorporating the effects of mutual coupling via a closed-form expression for the array impedance matrix. The mutual coupling matrix affects the incident signal like a set of narrowband beamformers; this interpretation is explored. The array's super-resolution direction finding (SRDF) behavior/performance in the presence of mutual coupling is explored. Simulation results examine the effects of mismatch in antenna termination impedance upon DF performance, using parameters from a typical mobile cellular radio environment scenario. The results indicate that array DF performance can be improved by mismatching the array terminations, thus reducing the effect of mutual coupling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Calcific Cardiomyopathy in Advanced Renal Failure (1975)

Four uremic patients on maintenance hemodialysis developed intractable heart failure and atrioventricular block. All had persistently high (over 60) calcium-phosphorus products. At autopsy, all had metastatic myocardial calcification. Their inability to take phosphate-binding agents orally is responsible for this fatal complication.
Preparation of Controlled Release Tablets of TA-5707F with Wax Matrix Type and Their in vivo Evaluation in Beagle Dogs. (1995)

Studies on controlled release dosage forms were conducted by using waxy materials for a newly developed anti-allergy drug, 6-methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (TA-5707F), which is not maintained at an effective level in blood for a long duration. Four kinds of tablets were prepared by changing the amount of hydrogenated oil (K3 wax) and polyethyleneglycol-6000 in the tablets. Then, they were administered orally to beagle dogs, and the TA-5707F concentration in the plasma was determined by a HPLC method. The pharmacokinetic parameters were estimated and compared with the results of the in vitro dissolution test determined by the JP paddle method and by the disintegration method. The linearity between the in vivo mean dissolution time (MDT) and in vitro MDT was good in both in vitro dissolution methods. However, the MDTs obtained by the disintegration method were one-third of the in vivo MDT, while those obtained by the paddle methods were 3 times higher. This suggests that both the diffusion of TA-5707F through the waxy matrix and the erosion of the wax matrix caused by the gastrointestinal (GI) tract mobility contributed to the in vivo dissolution mechanism. The blood levels were very low when the tablet was administered after giving food. The prolongation of resident time in the stomach and the low solubility of TA-5707F in an acidic medium seemed to be related to the phenomena. By the depression of GI motility using propantheline bromide, the blood levels could be markedly prolonged and the area under the plasma concentration-time curve (AUC) increased 1.3 times.
Comparative Case Study of Four Diversity and Inclusion Summit Events (2024)

She holds an endowed chair, the Dow Directorship for the Multicultural Engineering Program. Bitsie-Baldwin is a
Downsizing Semantic Reasoning to Fixed and Mobile DTV Receivers (2007)

Semantic reasoning is being increasingly applied in digital TV as a means to provide personalized information services. The pioneering initiatives have opted to place the personalization engines in the service providers' side, because the semantic mechanisms exceed - by far - the computational power of DTV receivers. Unfortunately, this approach has the drawback that it can expose data about the users' interests and preferences to commercial entities, raising severe legal and ethical obstacles. Moreover, in a domain where most of the information is transmitted through broadcast, there are many cases of intermittent, sporadic or null access to a return channel, which make the personalization features unavailable if lodged remotely. With these problems in mind, this paper introduces an architectural approach to deliver personalized DTV services, downsizing a semantic reasoning process to match the capabilities of fixed and mobile receivers. Preliminary experiments are reported, showing up to what point the enhanced privacy and availability impinge on personalization quality.
Angle stability and outflow in dual blade ab interno trabeculectomy with active versus passive chamber management (2017)

AS-OCT demonstrated that active irrigation and aspiration improved anterior chamber maintenance and ease of handling with the aDBG in this MIGS training model. The immediate postoperative outflow was equally good with both devices.
Bactericidal/Permeability-Increasing Protein (rBPI21) in Patients with Hemorrhage Due to Trauma (1999)

rBPI21 was well-tolerated and demonstrated a favorable trend in reducing the composite primary end point of mortality or serious complication through day 15, especially respiratory complications, in patients with hemorrhage due to trauma. A phase III study is currently in progress.