gebhart/patrepeval huggingface dataset:
Coulometric Titration of Aniline (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoulometric Titration of AnilineR. P. Buck and E. H. SwiftCite this: Anal. Chem. 1952, 24, 3, 499–501Publication Date (Print):March 19, 1952Publication History Published online1 May 2002Published inissue 19 March 1952https://pubs.acs.org/doi/10.1021/ac60063a018https://doi.org/10.1021/ac60063a018research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Micromanipulator: Effectiveness in Minimally Invasive Neurosurgery (2003)

Minimally invasive surgeries by innovative approaches are practiced in all fields. The evolution of microneurosurgery has revolutionized the results in neurosurgery. Use of endoscopes and navigation has made microsurgery less invasive. Another development to make minimally invasive microneurosurgery further lesser invasive is the use of micromanipulator. The use and effectiveness of manually controlled micromanipulator system is presented. The manually controlled micromanipulator system consists of three parts, i.e., a basic micromanipulator, manipulator supporting device and the manual control. The micromanipulator fitted in supporting device is arranged before the start of surgery. The supporting device used is pneumatically driven powered endoscopic holding device (Mitaka Kohki Co., Tokyo) In maximum number of times we used the system for endoscopic assisted cerebrovascular microneurosurgery. In a span of two months we used it in thirty aneurysm clipping surgeries. The endoscope fitted in system has three ranges of motions (forward/backward, upside/down and sideways). We use MACHIDA rigid endoscope with internal diameter of 2.7 mm (smallest diameter endoscope available). Special features of this endoscope are accurate visualization at a deeper plane, stable movements and availability of single focus point for long time. All these features are valuable during pre- and postoperative clipping observation. The aim of development of micromanipulator system was to further reduce invasiveness. A significant improvement in manual dexterity is possible when working through the micromanipulator interface, which dampens human physiological tremor. The physiological tremor would render the manual dexterity unsafe at the end of lever arm of long instruments. Thus, the use endoscope becomes practical. The minimally invasive microneurosurgery can be further made lesser invasive by use of micromanipulator and we are convinced that this will facilitate more accurate and promising results in microneurosurgery.
The development of Ce3+-activated (Gd,Lu)3Al5O12garnet solid solutions as efficient yellow-emitting phosphors (2013)

Ce<sup>3+</sup>-activated Gd<sub>3</sub>Al<sub>5</sub>O<sub>12</sub> garnet, effectively stabilized by Lu<sup>3+</sup> doping, has been developed for new yellow-emitting phosphors. The powder processing of [(Gd<sub>1-<i>x</i></sub> Lu <sub><i>x</i></sub> ) <sub><i>1</i>-<i>y</i></sub> Ce <sub><i>y</i></sub> ]<sub>3</sub>Al<sub>5</sub>O<sub>12</sub> solid solutions was achieved through precursor synthesis via carbonate precipitation, followed by annealing. The resultant (Gd,Lu)AG:Ce<sup>3+</sup> phosphor particles exhibit typical yellow emission at ∼570 nm (5d-4f transition of Ce<sup>3+</sup>) upon blue-light excitation at ∼457 nm (the <sup>2</sup>F<sub>5/2</sub>-5d transition of Ce<sup>3+</sup>). The quenching concentration of Ce<sup>3+</sup> was determined to be ∼1.0 at% (<i>y</i> = 0.01) and the quenching mechanism was suggested to be driven by exchange interactions. The best luminescent [(Gd<sub>0.9</sub>Lu<sub>0.1</sub>)<sub>0.99</sub>Ce<sub>0.01</sub>]AG phosphor is comparative to the well-known YAG:Ce<sup>3+</sup> in emission intensity but has a substantially red-shifted emission band that is desired for warm-white lighting. The effects of processing temperature (1000-1500 °C) on the spectroscopic properties of the phosphors, especially those of Lu<sup>3+</sup>/Ce<sup>3+</sup>, were thoroughly investigated and discussed from the centroid position and crystal field splitting of the Ce<sup>3+</sup> 5d energy levels.
Patterns of calcium signaling: A link between chronic emotions and cancer (2017)

Intra and inter-cellular calcium signaling is present in all types of cells and body tissues. In the human brain, calcium currents and waves are related to mental activities, including emotions. We present a theoretical interpretation of these phenomena suggesting their involvement in chronic emotional patterns and in the pathology of cancer. Recent developments on biophysics, translational biology and psychoneuroendocrinoimmunology (PNEI) can support explanatory hypotheses about the link between emotional stresses and the origin and development of different types of tumor cells. Chronic stresses may cause perturbations of rhythms of the PNEI system, excessive activation of HPA axis and abnormal activation of calcium signals in somatic tissues, with deleterious effects on different parts of the body. The increasing of calcium signaling inside cells may lead to a deregulation of different pathways and epigenetic systems that promote the production of genomic mutations in a second phase. In particular, the hyperactivation of the transcription nuclear factor kappaB (NF-κB), if is not counterbalanced by the following activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2), increases the production of oxidative catabolites, as the advanced glycation end products (AGE), which play a key role in the progression of different types of cancer and other degenerative diseases. Cortisol binding to glucocorticoid receptor (GR) reduces the activity of both NF-κB and Nrf2 inside the cells but inhibits the cellular immunity and the anabolic processes of tissue regeneration. The tissue atrophy and the defective anti-ageing mechanisms promotes the tumoral cells growth and their escape from the immune-surveillance.
Effect of Detailed Fetal Echocardiography as Part of Routine Prenatal Ultrasonographic Screening on Detection of Congenital Heart Disease (1997)

Stumpflen, Ingrid; Stumpflen, Andreas; Wimmer, Maria; Bernaschek, Gerhard Author Information
Bio-inspired nanostructure: DNA-based plasmonic assemblies, chirality, and transparency window effect (Conference Presentation) (2016)

Bio-inspired Nanostructures: DNA-based plasmonic assemblies, chirality and transparency window effect.
Imaging Performance of Confocal Fluorescence Microscopes with Finite-sized Source (1994)

Abstract The role of the illumination system of the confocal microscope, and in particular the first pinhole, is discussed. The effects of a finite sized source on the imaging performance, including the three-dimensional optical transfer function, are investigated. Two forms of source are considered, either a coherent Gaussian beam of finite size or an incoherent disc of finite size. For a confocal microscope using optical fibres as source and detector, the optimum geometry is derived for maximizing signal strength.
Enterotoxic Effect of the Vacuolating Toxin Produced byHelicobacter pyloriin Caco‐2 Cells (1998)

Preliminary clinical evidence suggests that Helicobacter pylori may be associated with diarrhea through its vacuolating toxin (VacA). To establish whether VacA induces intestinal secretion, epithelial damage, or both, purified pH-activated VacA was added to Caco-2 cell monolayers mounted in Ussing chambers, and electrical parameters were monitored. Mucosal addition of VacA induced an increase in short circuit current, consistent with enterotoxic effect. The effect was time- and dose-dependent and saturable. It was not found if the toxin was not pH-activated, added to the serosal side, or preheated. In cells preloaded with the Ca2+ buffering compound BAPTA/AM or with the Cl- channel inhibitor 5-nitro-2-3-(3-phenylpropylamino)benzoic acid, short circuit current did not change, indicating that VacA induces activation of Ca2+-dependent Cl- channels. VacA did not show cytopathic effects, as judged by tissue resistance. These results support the hypothesis that H. pylori may be associated with diarrhea through production of VacA.
Coupled bulk acoustic wave resonator filters: key technology for single-to-balanced RF filters (2004)

Coupled Resonator Filters (CRF) are a new type of Bulk Acoustic Wave (BAW) device in which two piezoresonators are stacked on top of each other in a way that a certain degree of acoustic interaction occurs. CRFs feature complete galvanic isolation between input and output and thus enable to offer BAW filters with mode-conversion (single-ended to balanced) as well as impedance transformation. The basic concept behind these devices is reviewed. The size of a CRF BAW filter is excitingly small as compared to SAW filters. First experimental results for CRFs operating at 1.8 GHz which have been manufactured at Infineon Technologies will be presented. Certain manufacturing issues are discussed and measurements of the temperature coefficient TCF are shown.
Energy Setting and Visual Outcomes in SMILE: A Retrospective Cohort Study (2018)

The lower end of the energy studied was associated with a better postoperative UDVA in this population. The spot-track-distance of 4.5 μm with 125 nJ energy was the optimal combination within this range. [J Refract Surg. 2018;34(1):11-16.].
Ion energy diagnostics for voltage determinations in plasma-erosion-opening-switch experiments (1987)

Abstract : A number of nuclear techniques have been developed and used to measure ion-diode voltages for plasma-erosion-opening-switch (PEOS) experiments on the Gamble II pulsed-power generator at NRL. The voltage is determined by measuring the energy of protons or deuterons from the diode. The techniques include neutron time-of-flight, neutron-intensity measurements, delayed activations, and stacked-foil activations. These diagnostics have evolved as the voltage developed in PEOS experiments have increased from less than 1 MV to more than 4 MV. Examples of these diagnostics are presented, and the extension of some of these techniques to voltages of more than 20 MV is described. Keywords: Pulsed power; Plasma erosion-opening-switch; Ion-diode voltage; Neutron time-of-flight; Ion-beam activation and Stacked-foil activation.
Abstract A14: Neoepitope-specific CD8+ T cells in adoptive T-cell transfer (2020)

Abstract Adoptive T-cell therapy (ACT) relies on expansion of tumor-infiltrating lymphocytes and infusion into patients following lymphodepletion, which have yielded complete responders in up to 25% of treated patients suffering from metastatic melanoma. However, a large proportion of patients have no clinical benefit (50-60%). Previous studies have found that clinical outcome correlates with tumor mutational and putative neoantigen load. Furthermore, expression of core antigen-presentation pathways including MHC class I genes in tumors correlates with clinical benefit. Based on these findings, we hypothesize that the presence of neoepitope-specific CD8+ T cells within the infusion product of ACT is a key determinant of clinical benefit. We apply in silico prediction of neoepitopes along with DNA-barcoded dextran multimer libraries to screen for personal neoepitope-specific CD8+ T cells. We show persistence of neoepitope-specific CD8+ T cells within patient peripheral blood for up to 24 months after therapy. Furthermore, we show an almost complete lack of neoepitope-specific CD8+ T cells within the infusion products of patients with progressive disease. However, patients with stable disease and long-term responses only have a modest increase in the number of targeted neoepitopes, as wells as the total frequency of neoepitope-specific CD8+ T cells. For future experimentation, we therefore aim to include more patients as well as study the phenotypical differences within the pool neoepitope-specific CD8+ T cells, the ultimate goal being a better understanding of what parameters from neoepitope-specific CD8+ T cells correlate with clinical efficacy of ACT. Citation Format: Nikolaj Pagh Kristensen, Christina Heeke, Siri A. Tvingsholm, Anne-Mette Bjerregaard, Arianna Draghi, Amalie Kai Bentzen, Rikke Andersen, Marco Donia, Inge Marie Svane, Sine Reker Hadrup. Neoepitope-specific CD8+ T cells in adoptive T-cell transfer [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr A14.
Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis. (2000)

The incidence of SLE in Sweden was notably constant during the 11 years 1981-91. Mortality was low and only late mortality (> 10 years disease duration) exceeded that in an age and sex matched control population. Atherosclerosis was the main cause of damage and mortality. Specificity and sensitivity of the ACR classification criteria are high in this epidemiologically recruited cohort.
The role of delamination in failure of fibre-reinforced composites (2012)

The mechanisms by which delamination contributes to the failure of fibre-reinforced composites are reviewed. Through-thickness failure owing to interlaminar stresses is considered first, and the effect of delamination in impact and compression after impact. The way in which in-plane failure can occur by delamination and matrix cracks joining up to produce a fracture surface without the need to break fibres is considered next. Examples of quasi-isotropic laminates loaded at different off-axis angles, and with different numbers and thicknesses of ply blocks show large differences in unnotched tensile strength controlled by delamination from the free edge. Similar mechanisms determine the strength of notched specimens and give rise to the hole size effect, whereby tensile strength increases with decreasing hole diameter owing to increased delamination and splitting. Open hole tension and over-height compact tension tests with constant in-plane dimensions show a transition in failure mode with increasing ply block thickness from fibre-dominated fracture to complete delamination. In all these cases, the critical factor controlling strength is the relative propensity to delaminate.
Interleukin‐1 alpha gene intron containing variable repeat region coding for the SP1 transcription factor recognition sequence is polymorphic (1989)

Interleukin-1 alpha (IL-1 alpha) is a cytokine produced by a number of cell types including macrophages, fibroblasts, keratinocytes, and mesangial cells. We were interested in identifying a DNA restriction fragment length polymorphism (RFLP) for the IL-1 alpha gene for use in studies of genetic alteration in various human cancers. Human genomic DNA from 32 unrelated individuals was digested with various restriction enzymes, alone and in combination, and subjected to Southern blot analysis. Hybridization to 32P-labeled IL-1 alpha cDNA revealed an insertion-deletion-type polymorphic pattern. After digestion with RsaI, insertion-deletion-type polymorphic bands with sizes of 3.4 kb, 3.1 kb, and 2.8 kb and one invariant band of 0.8 kb were observed. These three alleles, designated A1, A2, and A3, had relative frequencies of 0.18, 0.06, and 0.78 with heterozygosity observed in 38% of the unrelated individuals studied. Evaluation of nine related individuals for this RsaI polymorphism was consistent with a Mendelian inheritance. Comparison of restriction patterns following Southern analysis of DNA digested with several different enzymes showed that the polymorphic region resides within the sixth intron. Furthermore, this RFLP results from a variable length region containing multiple copies of a recognition sequence for SP1, an imperfect copy of viral enhancer elements, and an inverse and complementary sequence of the glucocorticoid receptor binding site. The identified polymorphism may be of value in analyses of chromosome 2 and may help to elucidate mechanisms by which IL-1 alpha transcription is regulated.
Carotid bruits and their clinical significance. (1984)

Vascular murmurs were routinely sought over the carotid arteries in 1,777 outpatients of 40 years of age or older who attended the cardiovascular clinic of our institute, and carotid bruits were heard in 82 patients (4.6%). The prevalence of carotid bruits increased with age from 5/467 (1.1%) in patients aged 40 to 49 years to 26/150 (17.3%) in those aged 70 to 79 years. Calcification of the carotid arteries was examined by posteroanterior films of the cervical spine in 447 patients 60 years of age or older and carotid calcification was found in 20 (42.6%) of 47 patients with carotid bruits and in 50 (12.5%) of 400 patients without them. The incidence of carotid calcification in the former group was 3.4 times that in the latter (p less than 0.01), although the incidences of hypertension and glucose intolerance were not related to the presence or absence of carotid bruits. A history of cerebral bleeding or infarction was found in 19 (23.2%) of 82 patients with carotid bruits, as compared with 64 (3.8%) of 1,695 patients without them (p less than 0.01). However, the location of the cerebrovascular lesions did not necessarily correlate with the laterality of the carotid bruits. These results indicate that patients with carotid bruits show an increased risk of stroke and that these bruits are a general and non-focal sign of severe atherosclerotic cerebrovascular disease.
Agile Montagesystem durch Konsens von Roboter- und Sensornetzwerk – Eine Einführung zur Industrie 4.0 (2019)

Abstract zum Tagungsbeitrag
Methylene Blue- and Thiol-Based Oxygen Depletion for Super-Resolution Imaging (2013)

Anaerobic conditions are often required in solution-based bionanotechnological applications. Efficient oxygen depletion is essential for increasing photostability, optimizing fluorescence signals, and adjusting kinetics of fluorescence intermittency in single-molecule fluorescence spectroscopy/microscopy, particularly for super-resolution imaging techniques. We characterized methylene blue (MB)- and thiol-based redox reactions with the aim of designing an oxygen scavenger system as an alternative to the established enzyme-based oxygen scavenging systems or purging procedures. Redox reactions of the chromophore methylene blue in aqueous solution, commonly visualized in the blue bottle experiment, deplete molecular oxygen as long as a sacrificial reduction component is present in excess concentrations. We demonstrate that methylene blue in combination with reducing compounds such as β-mercaptoethylamine (MEA) can serve as fast and efficient oxygen scavenger. Efficient oxygen scavenging in aqueous solution is also possible with mere β-mercaptoethylamine at mM concentrations. We present kinetic parameters of the relevant reactions, pH-stability of the MB/MEA-oxygen scavenging system, and its application in single-molecule based super-resolution imaging.
New method for isoquinuclidine synthesis. Total synthesis of desethylibogamine (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew method for isoquinuclidine synthesis. Total synthesis of desethylibogamineWataru. Nagata, Shoichi. Hirai, Kyozo. Kawata, and Tamotsu. OkumuraCite this: J. Am. Chem. Soc. 1967, 89, 19, 5046–5048Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/ja00995a041https://doi.org/10.1021/ja00995a041research-articleACS PublicationsRequest reuse permissionsArticle Views489Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gravel-Pack Logging Experiments (1985)

ABSTRACT Gravel pack logging experiments were conducted in a full-scale test well to define the factors that affect tool response and to determine if quantitative log interpretation is practical. Gamma-gamma and compensated neutron gravel pack logging tools from five major service companies were used in the study. Results show that these logging tools are sensitive to varying conditions in the gravel pack environment. Quantitative interpretation of the amount of gravel in the pack is possible as long as borehole conditions such as casing size, liner configuration and wellbore fluid density are known.
Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE Study. (2005)

Patients receiving interferon beta-1a improved on clinical and MRI disease measures when they changed from 30 microg QW to 44 microg TIW.
Superimposed in-fiber grating structures for optical signal processing in wavelength-division-multiplexing systems (2002)

We design superimposed in-fiber grating structures to work as multi-channel real-time optical spectrum analyzers for wavelength-division-multiplexing applications. The potential applications of the technique proposed here, as well as extensions to other signal treatments, are also analyzed.