gebhart/patrepeval huggingface dataset:
Studies on fluorinated pyrimidines. III. Synthesis of 1-acyl- and 1,3-diacyl-5-alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils. (1982)

1-Acyl- and 1, 3-diacyl-5-alkoxycarbonyl-5-fluoro-6-substituted-5, 6-dihydrouracils were synthesized for study as a class of pro-drugs of 5-fluorouracil (5-FU).
Determining the Productivity of a Barrier Island Sandstone Deposit From Integrated Facies Analysis (1990)

Summary Two crossplot techniques, based on core-calibrated resistivity, porosity, and gamma ray (GR) logs, are described that distinguish barrier island sandstones from genetically different nonbarrier sandstones in the Muddy sandstone reservoir in Unit A of Bell Creek field, Montana. The barrier island sandstones are separated further and grouped into two log facies, one consisting of highly productive facies (foreshore, shoreface, etc.) and the other, a less-productive facies (lower shoreface). The distinct crossplot pattern for each facies group is due to similar petrophysical properties of each facies group resulting from deposition within a unique depositional setting. Fluid production results from primary, secondary, and two EOR pilot projects indicate that in the barrier island reservoir at Bell Creek, the distribution of facies, with their characteristic reservoir properties and heterogeneities, dominates primary production, waterflood-sweep efficiency, distribution of residual oil saturation, and the performance of the chemical EOR pilot projects.
El tiempo libre y ocio reivindicado por los trabajadores (2006)

Estas líneas están referidas a la realización de actividades del ocio en el tiempo libre que&#13;\ncomo derecho ha sido logrado por las luchas de aquellas sociedades cuyo desarrollo industrial y comercial&#13;\nes caracterizado por la designación de tiempos para la producción o distribución de las mercancías.&#13;\nLos trabajadores históricamente han luchado por el derecho a un tiempo libre necesario para el desarrollo&#13;\nde las aptitudes del hombre, asunto que tratamos de discurrir, o en el mejor de los casos, reflexionar.
Transcranial near-infrared laser therapy applied to promote clinical recovery in acute and chronic neurodegenerative diseases (2011)

One of the most promising methods to treat neurodegeneration is noninvasive transcranial near-infrared laser therapy (NILT), which appears to promote acute neuroprotection by stimulating mitochondrial function, thereby increasing cellular energy production. NILT may also promote chronic neuronal function restoration via trophic factor-mediated plasticity changes or possibly neurogenesis. Clearly, NILT is a treatment that confers neuroprotection or neurorestoration using pleiotropic mechanisms. The most advanced application of NILT is for acute ischemic stroke based upon extensive preclinical and clinical studies. In laboratory settings, NILT is also being developed to treat traumatic brain injury, Alzheimer's disease and Parkinson's disease. There is some intriguing data in the literature that suggests that NILT may be a method to promote clinical improvement in neurodegenerative diseases where there is a common mechanistic component, mitochondrial dysfunction and energy impairment. This article will analyze and review data supporting the continued development of NILT to treat neurodegenerative diseases.
A torso haptic display based on shape memory alloy actuators (2003)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
The liver copper status alters the development of steatosis in mice (2020)

Background The association between copper (Cu) misbalance and liver steatosis has been reported in experimental models and in human disease. Inactivation of the copper transporter ATP7B causes copper (Cu) accumulation in the liver and Wilson Disease (WD). The contribution of Cu misbalance to the development of liver steatosis is not well understood.
ARPES studies of Na0.7CoO2 system (2005)

The hospital information system developed by Research Institute of Medical Bionics during 1976--1980 provides the means to enter and update files continually during a patient's stay in hospital. Particular external diagram provide the access the relationship for each user. Only data relevant to the user level is revealed by the system. For illustration, a detailed description of an external diagram of the First Neurological Clinic of Komenský's University Medical School is shown to inform the reader about the practicability of the system for nurses and physicians during daily routine.
Wind turbine control for highly turbulent winds (2009)

The constant expansion of wind power plants and ever increasing energy needs result in a need for wind turbine installation in areas with complex terrain and highly turbulent winds. Wind turbine control during such winds is very difficult task that often cannot be efficiently accomplished by classic wind turbine control system. This paper presents a novel approach to the wind turbine control intended for a wind turbine operation during strong and gusty winds. The approach relies on a combined use of generator electromagnetic torque and pitch control. Generator electromagnetic torque is used as an intermittent braking torque that assists pitch actions during wind gusts. The proposed control approach can cause an electrical system overload if not designed appropriately. Therefore a methodology for the control system tuning that can guarantee safe operation of the system has been developed. The paper firstly describes the classic wind turbine control system and outlines the process of the control system design. Secondly, the proposed control approach is explained and controller tuning process is described. It is finally validated against the performance of a fine tuned classic control system. Testing of the control system is performed according to international standards using a professional wind turbine simulator.
Polyhedral boron-containing cluster chemistry: Aspects of architecture beyond the icosahedron (2003)

Abstract For the structural extent of the polyhedral molecular chemistry of boron to rival that of the organic chemistry of the carbon hydrides, (a) the individual boron-containing polyhedra need to be fused together to make larger contiguous covalent assemblies, and (b) an intermolecular chemistry needs to be developed. Contemporary examples are given that illustrate novel chemistry in both these areas and that may point the way to some future developments.
Nursing management of an open abdominal wound (1988)

Articles| July 01 1988 Nursing management of an open abdominal wound PA Meehan; PA Meehan Search for other works by this author on: This Site PubMed Google Scholar EJ Mayz EJ Mayz Search for other works by this author on: This Site PubMed Google Scholar Crit Care Nurse (1988) 8 (4): 29–34. https://doi.org/10.4037/ccn1988.8.4.29 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Cite Icon Cite Get Permissions Citation PA Meehan, EJ Mayz; Nursing management of an open abdominal wound. Crit Care Nurse 1 July 1988; 8 (4): 29–34. doi: https://doi.org/10.4037/ccn1988.8.4.29 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCritical Care Nurse Search Advanced Search You do not currently have access to this content.
Immunoaffinity Column Cleanup with Liquid Chromatography Using Post-Column Bromination for Aflatoxins in Medicinal Herbs and Plant Extracts (2005)

A new and accurate method to quantitate aflatoxins in medicinal herbs is developed. This method consists of extraction of the sample with MeOH-H2O (70:30) followed by clean-up of the extracts with immunoaffinity columns and, finally, high-performance liquid chromatographic determination with fluorescence detection. Aflatoxins B1 and G1 are determined as their bromine derivatives, produced in an online post-column derivatization system. The overall average recoveries for three different medicinal herbs spiked at levels of 1.3 and 2.6 ng/g of total aflatoxins range from 93% to 97%. The detection limit is 0.15 ng/g for both G2 and B2 and 0.20 ng/g for both G1 and B1, based on a signal-to-noise ratio of 3:1 and a precision (within-laboratory relative standard deviation) ranging from 0.8% to 1.4%. The use of immunoaffinity columns provides excellent clean-up of these particular extracts, which are generally difficult to analyze. The method is applied successfully to 96 samples of natural drugs.
Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight (1997)

The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of thiourea at a 2:1 molar ratio with respect to the substrate. Under these conditions, a major product was formed which was isolated and identified as a 1:1 dopa-thiourea adduct (adduct I). Subsequent stages of the oxidation were characterized by the development of a yellow chromophore (lambdamax 440-460nm), virtually identical to that obtained by separate oxidation of the adduct I. A less remarkable effect of thiourea was observed on the oxidative polymerization of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) which was apparent on spectrophotometric and high pressure liquid chromatography (HPLC) analysis. Radiolabelling experiments with 14C-thiourea showed that the label was initially incorporated into the adduct I, while in the subsequent stages of the oxidation it was associated with pigmented materials which escaped direct analysis. Incorporation of labelled thiourea into dopa-melanins was found to be significantly higher than incorporation into synthetic pigments from indole precursors. These results provide a chemical basis for the interpretation of the selective accumulation of thiourea in those melanoma areas with high rates of melanin synthesis seen in autoradiographic experiments.
A hierarchical search algorithm for discrete element method of greatly differing particle sizes (2009)

Purpose A critical step toward an efficient contact detection algorithm is to localize the contact search to the immediate neighborhood of each particle. In particular, cell‐based algorithms are simple and require O ( N ) computations but become inefficient when the particles are not roughly the same diameter. The purpose of this paper is to describe a hierarchical search method with the simplicity and efficiency of the neighbor search algorithm but which is insensitive to size gradation. Design/methodology/approach In this method, particles are allocated to cells based on their location and size within a nested hierarchical cell space. Contact searches are limited to neighboring particles of equal size within their own hierarchy and occasionally with particles of larger size when no contacts are found within their own hierarchy. Findings The method is shown to be effective for the most severe case of highly segregated particle distributions in which a large particle is surrounded by particles of much smaller size. Originality/value This paper is of value in concentrating on particular issues in implementing the hierarchical contact detection algorithm in a parallel computing environment using message‐passing interface.
RISC-V Barrel Processor for Deep Neural Network Acceleration (2021)

This paper presents a barrel RISC-V processor designed to control a deep neural network accelerator. Our design has a 5-stage pipeline data path with 8 hardware threads (harts). Each thread is executed under a strict round robin scheduler and is responsible for providing data and control signals to a neural network processing element (PE). Each PE is capable of arbitrary precision GEneral Matrix Vector (GEMV) operations. The execution of each thread is independent of other threads and any communication between threads are sent through shared memory via software. To reduce the area required for implementation, our processor is an implementation of the RV32I plus a set of custom CSRs for controlling the PEs. Our design passes all riscv_test written in assembly and compiled with RISC-V gcc. Our 8-hart barrel processor runs at 250 MHz with CPI of 1 and consumes 0.372W. To demonstrate the capabilities of our design, we computed a GEMV operation with an input matrix size of 8 by 128 and a weight matrix size of 128 by 128 with two-bit precision in only 16 clock cycles.
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates (2022)

ABSTRACT Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) can display 8 or 20 trimeric antigens as multivalent vaccines. Here, we characterized the biophysical, structural, and antigenic properties of 1c-SApNPs that present the BG505 UFO trimer with wildtype and modified glycans. Trimming the glycan shield improved Env recognition by broadly neutralizing antibodies (bNAbs) to the CD4 binding site and other major glycan-containing epitopes. In mice, rabbits, and nonhuman primates, glycan trimming increased the frequency of vaccine responders (FVR) and steered antibody responses away from immunodominant glycan holes and glycan epitopes. The mechanism of vaccine-induced immunity was examined in mice. Compared with the soluble trimer, two large 1c-SApNPs showed 420 times longer retention, 20-32 times greater presentation on follicular dendritic cell dendrites, and up-to-4 times stronger germinal center reactions in lymph node follicles. These findings will inform the next phase of HIV-1 vaccine development. ONE-SENTENCE SUMMARY Glycan trimming of HIV-1 Env immunogens improves the vaccine-induced neutralizing antibody responses in small animals and primates
Thin-shell plastic lenses for space and laboratory applications (2004)

We have identified an inexpensive, readily available, mechanically stable, extremely smooth, elastic, and mechanically uniform plastic suitable for thin film X-ray optics. Polyethylene terephthalate (PET) is easily deformed without losing its elastic properties or surface smoothness. Most important, PET can be coated with mono- or multilayers that reflect X-rays at grazing incidence. We have used these properties to produce X-ray optics made either as a concentric nest of cylinders or as a spiral. We have produced accurately formed shells in precisely machined vacuum mandresl or used a pin and wheel structure to form a continuously wound spiral. The wide range of medical, industrial and scientific applications for our technology includes: a monochromatic X-ray collimater for medical diagnostics, a relay optic to transport an X-ray beam from the target in a scanning electron microscop0e to a lithium-drifted silicon and microcalorimeter detectors and a satellite mounted telescope to collect celestial X-rays. A wide variety of mono- and multilayer coatings allow X-rays up to ~100 keV to be reflected. Our paper presents data from a variety of diagnostic measurements on the properties of the PET foil and imaging results form single- and multi-shell lenses.
A step forward in bar coding? (2011)

Journal Article A step forward in bar coding? Get access Dennis A. Tribble, Pharm.D., FASHP Dennis A. Tribble, Pharm.D., FASHP Chief Pharmacy Officer Baxa Corporation 790 Fentress Boulevard Daytona Beach, FL 32114 dennis.tribble@baxa.com Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 68, Issue 15, 1 August 2011, Page 1406, https://doi.org/10.2146/ajhp110220 Published: 01 August 2011
MPL mutations and palpable splenomegaly are independent risk factors for fibrotic progression in essential thrombocythemia (2016)

MPL mutations and palpable splenomegaly are independent risk factors for fibrotic progression in essential thrombocythemia
IL-10–Producing Infliximab-Specific T Cells Regulate the Antidrug T Cell Response in Exposed Patients (2017)

Infliximab (IFX) is a chimeric mAb that can lead to the appearance of anti-drug Abs. Recent research has identified the presence of circulating IFX-specific T cells in treated patients. The aim of the study was to analyze the functional characteristics of IFX-specific T cells, in particular their capability to produce biologically active regulatory cytokines. Drug-stimulated PBMCs or coculture systems were used to detect memory T cells in treated patients. The cytokines produced by IFX-specific T cells, T cell lines, and T cell clones were evaluated at the mRNA and protein levels. Drug infusion induced an increase in IL-10 serum levels in vivo, whereas other cytokines were unchanged. IL-10 mRNA was higher in IFX-stimulated PBMCs from treated patients compared with untreated patients. When analyzed longitudinally, an early IL-10 mRNA expression was observed. HLA class II-restricted IL-10 production by drug-specific T cells from exposed patients was observed in different experimental settings, such as a coculture system, sorted CD154<sup>+</sup> T cells, IFX peptide-stimulated PBMCs, and IFX-specific T cell clones. Finally, IL-10-producing drug-specific T cell clones downregulated the response of autologous effector T cells to IFX. Overall, these findings identify IFX-specific T cells as a source of biologically active IL-10 and suggest interference by IL-10-producing cells in the detection of drug-specific T cells.
Higher order structure of (1,3)‐β‐D‐glucans and its influence on their biological activities and complexation abilities (2008)

(1,3)-beta-D-Glucans form a group of biologically active biopolymers that exist in different structural organizations depending on the environmental conditions. The biological effect of (1,3)-beta-D-glucans is a core issue stimulating large research efforts of the molecular properties and their consequences for action as biological response modifiers. The fascination for these molecules increased further following the finding of their ability to form complexes of defined geometry with a number of structures, ranging from linear architectures as polymers or carbon nanotubes, to globular structures as gold particles or dye molecules. The fascinating information concerning the relationship between sample treatment history and molecular organization has not yet reached out to all the contributors within the field, resulting in unnecessary apparent inconsistencies in the literature. In addition to environmental conditions, the sample history is known to influence on the precise structural organization of these molecules. The present knowledge related to the structure of native as well as denatured, renatured and annealed (1,3)-beta-D-glucans is reviewed. The influence of their structural organization on the biological activity and complexation abilities is discussed, and some factors hindering progress in the understanding of their biological effects or complexation abilities are pointed out.
Redetermination of the crystal structure of tetralithium mononitride monohydride, Li4NH (2002)

Article Redetermination of the crystal structure of tetralithium mononitride monohydride, Li4NH was published on December 1, 2002 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 217, issue JG).
SURGICAL TREATMENT OF NECK HYPEREXTENSION IN MYOPATHIES (2006)

Introduction: Neck hyperextension (NH) is defined as a progressive increase of lordosis associated with a limitation in flexion of the cervical spine, which ultimately results in an inability to approximate the chin to the sternum. NH may occur in relation to several myopathies. It is characterized by a general weakness and contractures of the axial muscles which produces a progressive increase of lordosis associated with a limitation in flexion of the cervical spine, that forces the patient to assume awkward compensatory postures to maintain balance and level vision. This study reports on operative complications, the degree of correction, the achievement of a solid arthrodesis, the maintenance of the correction and the clinical assessment of 7 patients. Material and methods: Seven patients affected by various myophaties and NH were included. The mean age was 16.5 years (10–28 years). All underwent surgery, in which the paravertebral muscles were detached from the spinous processes and then transversally sectioned in order to bilaterally expose the laminas of vertebrae C2 to C7. The space between C1–C2 appeared mobile, while the spinous processes from C2 to C7 were close together and thus allowed only a very limited motion in between them. Ligamenti interspinosus and nuchae were detached and the facet joints from C2 to C7 were enlarged by capsulotomy. With a spreader rongeur, the interspinous spaces at each level were gently opened. Cortical cancellous autologue graft were shaped into wedges. After careful opening of each interspinous space, the bone wedges were driven between the spinous processes to maintain the achieved correction. The average follow-up time was 10.4 years (2.4–16.5 years). Results: No major surgical complications occurred. At follow-up, the average angle between C2–C7 in neutral position had decreased (p = 0.016) from 50.7 (40–70) to 21.4 (2–50). The range of motion in the C1–C2 joint remained unaffected, while it decreased in C2–C7 (p = 0.016) from 33.5 (15–64) to 1.8 (0–8). In all cases, a solid arthrodesis was achieved. Discussion and conclusion: The follow-up showed significant clinical improvement of posture in all patients. Our study has shown surgical treatment of NH to be an effective method within the whole series of seven patients, achieving both good immediate and good long-term results.
列宁《给代表大会的信》与二十年代中期党的领导中的个人争执 (1989)

在俄共（布）第十三次代表大会上,采取了一种异乎寻常的程序来解决总书记的问题：先由代表大会的代表们提出总书记的候选人，实际上已经事先决定了推选斯大林，而后再由中央全会“签署”他们的决定。这种程序本身，就把总书记置于其他政治局委员和中央全会之上，在某种意义上把总书记当成了独立于中央全会之上的人。