gebhart/patrepeval huggingface dataset:
Passive millimeter-wave focal plane array (2004)

We built and tested a low-cost 8-by-8 millimeter-wave focal plane array using antenna-coupled micro-bolometers. The array consists of slot antennas coupled to nickel bolometers and was fabricated using optical lithography on high-resistivity silicon wafers. The measured noise equivalent temperature difference (NETD) of an individual element was 450 K. Simulation results corresponded with observed device performance. An improved design was then implemented using a square spiral antenna. We discuss the fabrication of this type of array element, include some modeling results, and present the methods and results of our measurements.
5 GHz Channel Spacing InP-Based 32-Channel Arrayed-Waveguide Grating (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. Jiang, K. Okamoto, F. M. Soares, F. Olsson, S. Lourdudoss, and S. J. B. Yoo, "5 GHz Channel Spacing InP-Based 32-Channel Arrayed-Waveguide Grating," in Optical Fiber Communication Conference and National Fiber Optic Engineers Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper OWO2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Abstract 34: Diminished Contractile Capability In Cerebral Vascular Smooth Muscle Cells In The TgF344-AD Rat Model Of Alzheimer's Disease (2021)

We recently reported that cerebral vascular dysfunction leads to impaired autoregulation of cerebral blood flow (CBF), neurovascular coupling (NVC), and blood-brain barrier (BBB) leakage. The present study examined if cerebral vascular dysfunction precedes cognitive impairment in the TgF344-AD (AD) rat model of Alzheimer's disease. In the present study, we confirmed that the AD rats develop learning and memory deficits beginning at 24-week of age using an eight-arm water maze. AD rats (n = 11) took a longer time to escape and displayed more errors than age-matched wildtype (WT) rats (n = 6). We also completed a longitudinal comparison of the myogenic response (MR) of the middle cerebral artery (MCA) and found that the MR was similar in AD and WT rats at 8- to 12-week of age when perfusion pressure was increased from 40 to 180 mmHg. However, the MR was significantly reduced in 16-week old AD rats (n = 6) as the inner diameter of the MCA only decreased by 8.2 ± 2.4% when perfusion pressure was increased from 40 to 180 mmHg compared with 14.5% ± 2.0% in age-matched WT rats (n = 6). The impaired MR of the MCA was exacerbated in AD rats with aging. Autoregulation of CBF AD rats (n = 4) in vivo was impaired in the surface and deep cortex at 24-week of age compared to age-matched WT rats (n = 4). Furthermore, we found the contractile capability of the cerebral vascular smooth muscle cells (VSMCs) isolated from AD rats (n = 4) was significantly reduced compared with WT rats (n = 4), detected by the reduction in size of 15.7 ± 0.9% vs. 25.4 ± 1.0% using a collagen gel-based assay kit. These results provide evidence that cerebral VSMC dysfunction, impaired MR, and autoregulation of CBF precede the development of memory and learning deficits in the TgF344-AD rat model. However, the underlying mechanisms for the loss of VSMCs contractility in this AD model overexpressing mutant human amyloid precursor protein ( APPsw ) and presenilin 1 ( PS1ΔE9 ) genes remain to be determined. Nevertheless, these results provide novel insight into the vascular contribution to AD.
Ergebnisse Untersuchungen über die Frequenzabhängigkeit der Kreislaufreaktion bei Lärm (1958)

ZusammenfassungAbbildung 4 zeigt die Änderung des peripheren Kreislaufwiderstandes (dyn · sec · cm−5), der Pulsfrequenz (Pulse/Min.) und des Schlagvolumens des Herzens (cm3). Die Versuchsperson wurde über 20 Minuten mit einem weißen Geräusch des Frequenzbereiches 200 — 400 Hz. der Lautstärke 90 DIN-Phon und in der gleichen Lautstärke über 20 Minuten mit einem weißen Geräusch des Frequenzbereiches 3200 — 6400 Hz. beschallt. Im Bild ist oben der Verlauf eines Einzelversuches gezeichnet. Darunter sind die Mittelwerte aus vier gleichen Versuchen mit derselben Versuchsperson dargestellt. Unter Berücksichtigung der Änderungen des Blutdruckes und und der Pulswellenform allein schon durch die Atmung wurden die Einzelwerte eines Versuches aus je 3 Messungen des systolischen und des diastolischen Blutdruckes und je 20 Auswertungen der Pulswellen berechnet. Die für eine allgemeinere Aussage erforderlichen Mittelwerte über mehrere Versuche ergaben sich aus folgender Betrachtung: Die Einzelwerte in der Zeit vor dem Lärmbeginn wurden gemittelt. Von diesem Mittelwert aus wurde die Differenz zu jedem einzelnen Meßwert der Ruhe-, Lärm- und Nachperiode bestimmt. Diese Abweichungen in den einzelnen Kurven in jedem einzelnen Meßpunkt von dem Mittelwert der Ruheperiode dienten zur Mittel-, wertsbestimmung aus mehreren Versuchen. Open image in new window Abbildung 4 Der periphere Kreislaufwiderstand, die Pulsfequenz and das Schlagvolumen (nach WEZLER-BÖGER) ber Lärm im Einzelversuch und im Mittelwert aus 4 Versuchen mit gleicher Versuchsperson 200 — 400 Hz., 3200 — 6400 Hz., 90 phon
Synthesis of Human Plasminogen by the Liver (1980)

Genetic types of plasminogen were determined from a donor and a recipient before and after hepatic homotransplantation. Examination of the plasminogen types demonstrated that the liver is the principal site of synthesis of human plasminogen.
Drastic Control of Texture in a High Performance n-Type Polymeric Semiconductor and Implications for Charge Transport (2011)

Control of crystallographic texture from mostly face-on to edge-on is observed for the film morphology of the n-type semicrystalline polymer {[N,N-9-bis(2-octyldodecyl)naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,59-(2,29-bithiophene)}, P(NDI2OD-T2), when annealing the film to the polymer melting point followed by slow cooling to ambient temperature. A variety of X-ray diffraction analyses, including pole figure construction and Fourier transform peak shape deconvolution, are employed to quantify the texture change, relative degree of crystallinity and lattice order. We find that annealing the polymer film to the melt leads to a shift from 77.5% face-on to 94.6% edge-on lamellar texture as well as to a 2-fold increase in crystallinity and a 40% decrease in intracrystallite cumulative disorder. The texture change results in a significant drop in the electron-only diode current density through the film thickness upon melt annealing, while little change is observed in the in-plane transport of bottom gated thin film transistors. This suggests that the texture change is prevalent in the film interior and that either the (bottom) surface structure is different from the interior structure or the intracrystalline order and texture play a secondary role in transistor transport for this material.
327 Effects of additional Ce and Si elements to CoNiCrAlY on bond strength at the interface between thermal barrier coating and bond coating (2005)

Effects of additional Ce and Si e ements to CoNiCrAIY on bond
A novel SiNW/CMOS hybrid biosensor for high sensitivity/low noise (2013)

A novel silicon nanowire (SiNW)/CMOS hybrid biosensor was produced for the first time. The hybrid biosensor features a complementary SiNW block and CMOS logic inverter readout circuitry. The proposed hybrid biosensor shows remarkably sensitive output voltage (Δ1.2 V/Δ0.4 pH and Δ1.2 V/Δ200 fM DNA) without noise or fluctuations.
The Catalytic Cross-Coupling of Unactivated Arenes (2007)

The industrially important coupling of aromatic compounds has generally required differential prefunctionalization of the arene coupling partners with a halide and an electropositive group. Here we report that palladium, in conjunction with a copper oxidant, can catalyze the cross-coupling of N-acetylindoles and benzenes in high yield and high regioselectivity across a range of indoles without recourse to activating groups. These reactions are completely selective for arene cross-coupling, with no products arising from indole or benzene homo-coupling detected by spectroscopic analysis. This efficient reactivity should be useful in the design of other oxidative arene cross-couplings as well.
Undersampled Blade Tip‐Timing Vibration Reconstruction under Rotating Speed Fluctuation: Uniform and Nonuniform Sensor Configurations (2019)

Blade tip‐timing (BTT) is a promising method of online monitoring rotating blade vibrations. Since BTT‐based vibration signals are typically undersampled, how to reconstruct characteristic vibrations from BTT signals is a big challenge. Existing reconstruction methods are mainly based on the assumption of constant rotation speeds. However, rotating speed fluctuation is inevitable in many engineering applications. In this case, the BTT sampling process should be nonuniform, which will cause existing reconstruction methods to be unavailable. In order to solve this problem, this paper proposes a new reconstruction method based on nonlinear time transformation (NTT). Firstly, the effects of rotating speed fluctuation on BTT vibration reconstruction are analyzed. Next, the NTT of BTT sampling times under rotating speed fluctuation is presented. Then, two NTT‐based reconstruction algorithms are derived for uniform and nonuniform BTT sensor configurations, respectively. Also several evaluation metrics of BTT vibration reconstruction under rotating speed fluctuation are defined. Finally, numerical simulations are done to verify the proposed algorithms. The results testify that the proposed NTT‐based reconstruction method can reduce effectively the influence of rotating speed fluctuation and decrease the reconstruction error. In addition, rotating speed fluctuation has more bad effects on the reconstruction method under nonuniform sensor configuration than under uniform sensor configuration. For nonuniform BTT signal reconstruction under rotating speed fluctuation, more attentions should be paid on selecting proper angles between BTT sensors. In summary, the proposed method will benefit for detecting early blade damages by reducing frequency aliasing.
Urban network parcellation using graph theoretic approach (2015)

This paper investigates the street-based network topology of urban spaces as represented in Geographic Information Systems (GIS) databases. We apply graph theoretical spectral methods to analysis of ways in maps. Our findings show that such methods can find natural parcellations of spaces, thus capturing the significance and semantics of a location from analysis of topological structure of the underlying map connectivity structure. Such analysis might be important for semantic search in the “5D World Map” project.
Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing (1997)

Most receptor-like protein tyrosine phosphatases (PTPases) display a high degree of homology with cell adhesion molecules in their extracellular domains. We studied the functional significance of processing for the receptor-like PTPases LAR and PTPsigma. PTPsigma biosynthesis and intracellular processing resembled that of the related PTPase LAR and was expressed on the cell surface as a two-subunit complex. Both LAR and PTPsigma underwent further proteolytical processing upon treatment of cells with either calcium ionophore A23187 or phorbol ester TPA. Induction of LAR processing by TPA in 293 cells did require overexpression of PKCalpha. Induced proteolysis resulted in shedding of the extracellular domains of both PTPases. This was in agreement with the identification of a specific PTPsigma cleavage site between amino acids Pro821 and Ile822. Confocal microscopy studies identified adherens junctions and desmosomes as the preferential subcellular localization for both PTPases matching that of plakoglobin. Consistent with this observation, we found direct association of plakoglobin and beta-catenin with the intracellular domain of LAR in vitro. Taken together, these data suggested an involvement of LAR and PTPsigma in the regulation of cell contacts in concert with cell adhesion molecules of the cadherin/catenin family. After processing and shedding of the extracellular domain, the catalytically active intracellular portions of both PTPases were internalized and redistributed away from the sites of cell-cell contact, suggesting a mechanism that regulates the activity and target specificity of these PTPases. Calcium withdrawal, which led to cell contact disruption, also resulted in internalization but was not associated with prior proteolytic cleavage and shedding of the extracellular domain. We conclude that the subcellular localization of LAR and PTPsigma is regulated by at least two independent mechanisms, one of which requires the presence of their extracellular domains and one of which involves the presence of intact cell-cell contacts.
Nuclear magnetic resonance in the clinical laboratory. (1989)

Nuclear magnetic resonance (NMR) which now has widespread clinical use as an imaging technique, may also have significant application to diagnostic pathology. High-field proton NMR spectroscopy can perform rapid multicomponent analysis of serum, urine, cerebrospinal fluid, and even intact cells. This technique allows unusually detailed studies of certain metabolic derangements and toxic ingestions. Phosphorus NMR spectroscopy in vivo can measure ATP and other phosphometabolites, intracellular pH, and free Mg2+. It has been applied to diagnosing inborn errors of metabolism such as glycogen storage disease, monitoring growth and regression of tumors, and assessing tissue viability. The basics of NMR spectroscopy are reviewed in this article, along with a survey of applications in human pathology.
Spine Biomechanics in the Work of Aristotle (384 – 322 BC) (2022)

<b>Background:</b> Spine biomechanics is a field of applied research aiming to unravel the biomechanical understanding of the spine and its disorders and to understand the implications of their interventional therapy to improve clinical practice, physical performance and daily living. Its scientific whereabouts can be traced in the work of Aristotle, who discussed physical and biological concepts of spine biomechanics in a series of treatises.<b>Results:</b> The authors searched the Thesaurus Linguae Graecae archive for original texts written in Greek and attributed to Aristotle and selected excerpts of medical and biological treatises that elaborate on spine biomechanics.<b>Discussion:</b> While many of his theories have become outdated, his methodology and rationale remain relevant for contemporary researchers and clinicians. Here, the relevant content of passages of the corpus aristotelicum related to spine biomechanics and discuss their practical implications are presented.
Developing the Chemistry of Colloidal Cu Nanocrystals to Advance the CO₂ Electrochemical Reduction (2021)

The ability to tailor make materials with atomic scale precision is crucial for understanding the sensitivities of their performance parameters and for achieving the design specification corresponding to optimal device operation. Herein, this topic is discussed in the context of catalysis. The electrochemical CO₂ reduction reaction (CO₂ RR) holds the promise to close the carbon cycle by storing renewable energies in chemical feedstocks, yet it suffers from the lack of efficient and selective catalysts. This article highlights how colloidal chemistry can contribute to tackle this compelling issue by designing shape-controlled nanocatalysts. In particular, two case studies relative to copper nanocrystals are discussed.
Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2‐Silyloxyindoles (2015)

The first example of catalytic, enantioselective hypervinylogous Mukaiyama aldol reaction (HVMAR) involving multiply unsaturated 2-silyloxyindoles is reported. The reaction utilizes a chiral Lewis base-catalyzed Lewis acid-mediated technology to deliver homoallylic 3-polyenylidene 2-oxindoles with extraordinary levels of regio-, enantio-, and geometrical selectivity. This work highlights a subtle yet decisive influence of the indole N-substituents on the propagation of the vinylogous reactivity space of the donor substrates up to ten bonds away from the origin of the vinylogy effect. Analysis of the (13) C NMR chemical shifts of the C-ω remote site within homologous silyloxyindole donors enabled rationalization of the results and easy qualitative prediction of the HVMAR reactivity/inertia toward a given aldehyde acceptor.
Dose Dependent Relationship Between Blunting Of Exercise Gh Response And Bmi In Overweight Children (2009)

PURPOSE: Stimulation of the growth hormone®insulin-like growth factor-I (GH®IGF-I) axis during exercise is a key regulator of growth and development in children. While blunted exercise GH responses (with a possible negative impact on physiological growth) have been reported in obese (OW) and acutely hyperlipidemic healthy children, the degree of GH blunting relative to progressive obesity has not been elucidated. We therefore examined exercise GH response in groups of OW with progressively increasing BMI%. METHODS: 4 groups of children aged 9-17 years (43 normal weight, NW, BMI% 56±4, 25F; 18 with BMI% 95-97, 6F; 16 with BMI% 97-98.5, 7F; 21 with BMI% >98.5, 12F) performed 10 bouts of 2-min cycling at ∼80% VO2max, separated by 1-min rest intervals. Blood samples were drawn at baseline and end-exercise.FigureRESULTS: GH (ng/mL) increased in all groups with exercise, but GH increases, when compared to NW (11.5±1.0 ng/mL), were progressively more blunted with increasing BMI: 8.9±1.9, 6.7±1.7 (p<0.02), and 5.2±1.1 (p<0.001), respectively. There was no difference in IGF-I profiles between groups. While insulin (μU/ml) was significantly elevated (p<0.0001) in all three OW groups (12±2, 14±1, and 14±1) vs NW (5.8±0.5), a correlation with increasing BMI was not detected. CONCLUSIONS: Our data show a progressively greater blunting of the GH response to exercise with increasing adiposity in children over the age-adjusted 95th BMI%, suggesting that alterations in the overall health effects of exercise may occur with increasing severity in this group of subjects. The degree of GH blunting corresponded with the degree of obesity, possibly diminishing the growth effects of exercise. Grant support: NIH M01-RR00827-28, P01HD048721-01A1.
The Fire of Life: An Introduction to Animal Energetics (1975)

A study of the evolution of bioenergetics, this book examines total starvation and the physical aspects of metabolism, as well as the metabolism of the starving animal. It discusses food as fuel and looks at food and population.
[Myocardial perfusion scintigraphy in Germany. Results of the 2005 query and current status]. (2007)

In Germany, MPS is predominantly performed with (99m)Tc-perfusion agents. The common type of stress is ergometry. Gated SPECT and attenuation correction do not yet represent standards of MPS practice in Germany, which indicates some potential of optimization.
New bioactive textile dressing materials from dibutyrylchitin (2009)

Purpose Dibutyrylchitin (DBC) is an ester derivative of a natural polysaccharide – chitin. DBC is obtained by reaction of chitin with butyric anhydride in the presence of a catalyst. The production methods of DBC have been elaborated and optimized. DBC is easily soluble in common organic solvents and has film – and fibre forming properties. Such characteristics allow obtaining classical fibres from the polymer solutions. DBC is also a raw material for manufacturing yarn and for a broad range of textile dressing materials. Fibres with good mechanical properties are obtained by an optimized spinning process from the DBC solutions. The purpose of this paper is to present a further optimization of the mechanical properties of DBC-fibres and yarns. Design/methodology/approach The excellent biomedical properties of the DBC are confirmed by different experimental results which prove that DBC is a biocompatible and biodegradable polymer and stimulates regeneration of damaged tissues. Tests of these DBC dressing materials under clinical conditions prove the excellent results of DBC-based dressing materials for the ordered healing of tissues and wounds. The DBC dressing materials accelerate the healing of the wound and are biodegraded during the healing process. From the clinical tests, it can be clearly observed that the DBC dressing materials are absorbed into the fresh tissue formed during the healing process of the wounds. Findings The DBC and DBC-based dressing materials are good bioactive textile materials for wound healing and for understanding the biological properties of chitin derivatives. The obtained results prove the importance of the O-substitution of the hydroxyl groups present in chitin, not only for the solubility of the derivatives and the mechanical properties of the produced fibres, but still more important for the biological properties of these ester derivatives of chitin containing butyric acid. This development creates a link between textile products, based on material properties and human health, based on the biological properties of the basic material. Originality/value The mechanical properties of DBC are further optimized by blending it with poly(ε-caprolactone). Good transparent and flexible products, such as films, with a high elongation to break are obtained by blending 10-20 wt per cent of poly(ε-caprolactone) with DBC. This creates new possible bioactive applications for DBC or poly(ε-caprolactone).
Psychometric validation of the electronic chronic pain questions (eCPQ) in a primary care setting (2016)

The eCPQ has sound psychometric measurement properties, including concurrent validity, discriminant validity, and reproducibility. The eCPQ appears to be useful to identify patients with chronic pain and to assess and monitor symptoms over time.
Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer (2008)

Chromophore-assisted light inactivation is a promising technique to inactivate selected proteins with high spatial and temporal resolution in living cells, but its use has been limited because of the lack of a methodology to prevent nonspecific photodamage in the cell owing to reactive oxygen species generated by the photosensitizer. Here we present a design strategy for photosensitizers with an environment-sensitive off/on switch for singlet oxygen ((1)O(2)) generation, which is switched on by binding to the target, to improve the specificity of protein photoinactivation. (1)O(2) generation in the unbound state is quenched by photoinduced electron transfer, whereas (1)O(2) generation can occur in the hydrophobic environment provided by the target protein, after specific binding. Inositol 1,4,5-trisphosphate receptor, which has been suggested to have a hydrophobic pocket around the ligand binding site, was specifically inactivated by an environment-sensitive photosensitizer-conjugated inositol 1,4,5-trisphosphate receptor ligand without (1)O(2) generation in the cytosol of the target cells, despite light illumination, demonstrating the potential of environment-sensitive photosensitizers to allow high-resolution control of generation of reactive oxygen species in the cell.