gebhart/patrepeval huggingface dataset:
1,3-Diaxially Substituted trans-Decalins: Potential Nonsteroidal Human Progesterone Receptor Inhibitors (2008)

On the basis of molecular modeling and QSAR analysis of the known human progesterone receptor (hPR) inhibitor Mifepristone (RU-486) and other hPR ligands, a new class of potential nonsteroidal hPR inhibitors was designed. The parent racemic compound 1 was synthesized through an efficient 13-step synthetic pathway. The key constructive steps are a stereoselective epoxide ring opening and the reductive Heck cyclization to form the main framework of (+/-)-1. The current established flexible synthetic route allows for further chemical diversification.
Range of motion after stemmed total hip arthroplasty and hip resurfacing - a clinical study. (2009)

Range of motion after total hip arthroplasty is becoming an important topic as today's patients present at a younger age and are more active. An effective study design to carry out comparisons of clinical performance between two implants should eliminate patient-related extraneous variables (e.g., age, gender, activity level, among others). The aim of the present study was to compare the range of motion results achieved postoperatively between metalon-metal hip resurfacing (HR) and conventional total hip arthroplasty (THA) in a cohort of bilateral patients implanted with both designs. Thirty-five patients who had undergone bilateral surgery with one hip receiving an HR device and the contralateral hip receiving a THA were retrospectively selected. Sixty-nine percent of the patients were male, and at the time of implantation of the resurfacing device the mean age of the patients was 53 years. The mean follow-up time was 88 months for the hips treated with HR and 96 months for the hips that received a THA. We found no difference in any of the range of motion measurements between HR and THA even after separating the cohort into two groups based on the femoral head size of the THA (femoral heads under 40 mm and femoral heads greater or equal to 40 mm). Our investigation showed that, for most patients, prosthetic design is unlikely to be a limiting factor of range of motion after surgery provided that the positioning of the acetabular component is adequate.
Music training alters the course of adolescent auditory development (2015)

Fundamental changes in brain structure and function during adolescence are well-characterized, but the extent to which experience modulates adolescent neurodevelopment is not. Musical experience provides an ideal case for examining this question because the influence of music training begun early in life is well-known. We investigated the effects of in-school music training, previously shown to enhance auditory skills, versus another in-school training program that did not focus on development of auditory skills (active control). We tested adolescents on neural responses to sound and language skills before they entered high school (pretraining) and again 3 y later. Here, we show that in-school music training begun in high school prolongs the stability of subcortical sound processing and accelerates maturation of cortical auditory responses. Although phonological processing improved in both the music training and active control groups, the enhancement was greater in adolescents who underwent music training. Thus, music training initiated as late as adolescence can enhance neural processing of sound and confer benefits for language skills. These results establish the potential for experience-driven brain plasticity during adolescence and demonstrate that in-school programs can engender these changes.
Stronger Security Variants of GCM-SIV (2016)

At CCS 2015, Gueron and Lindell proposed GCM-SIV, a provably secure authenticated encryption scheme that remains secure even if the nonce is repeated. While this is an advantage over the original GCM, we first point out that GCM-SIV allows a trivial distinguishing attack with about 248 queries, where each query has one plaintext block. This shows the tightness of the security claim and does not contradict the provable security result. However, the original GCM resists the attack, and this poses a question of designing a variant of GCM-SIV that is secure against the attack. We present a minor variant of GCM-SIV, which we call GCM-SIV1, and discuss that GCM-SIV1 resists the attack, and it offers a security trade-off compared to GCM-SIV. As the main contribution of the paper, we explore a scheme with a stronger security bound. We present GCM-SIV2 which is obtained by running two instances of GCM-SIV1 in parallel and mixing them in a simple way. We show that it is secure up to 285.3 query complexity, where the query complexity is measured in terms of the total number of blocks of the queries. Finally, we generalize this to show GCM-SIVr by running r instances of GCM-SIV1 in parallel, where r ≥ 3, and show that the scheme is secure up to 2128r/(r+1) query complexity. The provable security results are obtained under the standard assumption that the blockcipher is a pseudorandom permutation.
Standards: Roadmapping Computer Technology Trends Enlightens Industry (2018)

The IEEE Standards Association’s Industry Connection program, with its International Roadmap for Devices and Systems (IRDS), takes over the Semiconductor Industry Association’s International Technology Roadmap for Semiconductors (ITRS).
Rate Control For Delay-Constrained Video Transmission (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
Modification of disease outcome in Salmonella-infected patients by HLA–B27 (2000)

Objective To study whether HLA–B27 modifies the outcome of Salmonella infection in vivo. Methods The frequency of HLA–B27 was determined in 198 Salmonella-infected patients and 100 healthy controls by immunofluorescence and polymerase chain reaction. The excretion of Salmonella was monitored at monthly intervals. The symptoms of acute infection and possible joint involvement were evaluated using questionnaires. Results Thirty-eight of 198 Salmonella-infected patients (19.2%) and 13 of 100 healthy controls (13.0%) were HLA–B27 positive. The excretion of Salmonella did not differ significantly between HLA–B27–positive and –negative patients, or for patients with versus those without joint symptoms. As many as 35 patients (17.7%) reported Salmonella-triggered joint symptoms. Three of 14 patients (21.4%) with arthralgia, 5 of 13 patients (38.5%) with probable reactive arthritis (ReA), and 6 of 8 patients (75%) with confirmed ReA were HLA–B27 positive. The duration and severity of joint symptoms directly correlated with HLA–B27 positivity. Women reported Salmonella-induced pain and swelling of joints more frequently than men (P = 0.07 and P = 0.03, respectively). Patients with Salmonella-triggered joint symptoms reported abdominal pain and headache more frequently than patients without joint symptoms (P = 0.05 and P = 0.004, respectively). Conclusion HLA–B27 did not (at least, not strongly) confer susceptibility to Salmonella infection. Salmonella excretion correlated neither with HLA–B27 positivity nor with the occurrence of joint symptoms. Joint symptoms were surprisingly common during or after Salmonella infection. HLA–B27–positive patients had a significantly increased risk of developing joint and tendon symptoms. Moreover, HLA–B27 positivity correlated with the development of more severe and prolonged joint symptoms.
Temporal Coherency in Video Tone Mapping, A Survey (2013)

International audience
Renal radiofrequency ablation with pyeloperfusion (2014)

Table S1 Postprocedural complications. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Ultra-Long-Haul WDM Transmission Using NANF Hollow-Core Fiber (2022)

Hollow-core fiber NANF prototypes have recently achieved lower loss and wider bandwidth than SMF. Theory predicts further progress may be possible. We investigate the potential impact of future high-performance NANFs on long-haul optical communication systems.
The Temperature of the Solar Corona (2003)

This paper is a historical survey of the temperature determinations in the solar corona. After the description of the early results, it focuses on coronal holes; it discusses the discrepancies of the past and comments on the nearly general
External Water Condensation and Angular Solar Absorptance : Theoretical Analysis and Practical Experience of Modern Windows (2007)

Part I of this thesis is a theoretical background to parts II and III. Part II treats the phenomenon of decreased visibility through a glazing due to external water condensation, dew, on the external surface. Some simulations are presented where it is shown that under certain circumstances condensation can be expected. A combination of coatings on the external surface is suggested to overcome the problem of external condesation. It consists of both a coating which decreases the emissivity of the surface and a hydrophilic coating which reduces the detrimental effects to the view through the window. Fresnel calculations of the optical properties are used to discuss the feasibility of using different coatings. A new test box was used to verify that the proposed window coatings perform as expected. Part III is a study on the angular dependence of solar absorptance in windows. Optical properties vary with the angle of incidence of the incoming light. The variation is different from one window pane to another. A model is proposed to approximate the angular variation of the solar absorptance in window panes. The model is semi-empirical and involves dividing the wide range of windows into nine groups. To which group a window belongs, depends on how many panes it has and on the features of the outer pane. The strength of the model is that it can be used without knowing the exact optical properties of each pane of the window. This makes it useful in the many cases when these data are not given by the manufacturer and Fresnel calculations to get the optical properties of the window are not feasible. The model is simple and can be added as an appendix to existing standards for measuring optical properties of windows.
Computers in Spaceflight: the NASA Experience (1988)

This book examines the computer systems used in actual spaceflight or in close support of it. Each chapter deals with either a specific program, such as Gemini or Apollo onboard computers, or a closely related set of systems, such as launch processing or mission control. A glossary of computer terms is included.
Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments (2019)

For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix remodeling is associated with enhanced osteogenic differentiation. However, the mechanism linking matrix remodeling in 3D to osteogenesis of MSCs remains unclear. Here, we find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis. Restriction of expansion by either hydrogels with slow stress relaxation or increased osmotic pressure diminishes osteogenesis, independent of cell morphology. Conversely, induced expansion by hypoosmotic pressure accelerates osteogenesis. Volume expansion is mediated by activation of TRPV4 ion channels, and reciprocal feedback between TRPV4 activation and volume expansion controls nuclear localization of RUNX2, but not YAP, to promote osteogenesis. This work demonstrates the role of cell volume in regulating cell fate in 3D culture, and identifies TRPV4 as a molecular sensor of matrix viscoelasticity that regulates osteogenic differentiation.
A STRAIGHT SECTION DESIGN IN RHIC TO ALLOW HEAVY ION ELECTRON COOLING (2006)

The Relativistic Heavy Ion Collider (RHIC) has been continuously producing exciting results. One of the major luminosity limitations of the present collider is the intra beam scattering. A path towards the higher luminosities requires cooling of the heavy ion beams. Two projects in parallel electron and stochastic cooling are progressing very well. To allow interaction between electrons and the RHIC beams it is necessary to redesign one of the existing interaction regions in RHIC to allow for the longer straight section with fixed and large values of the betatron functions. We present a new design of the interaction region for the electron cooling in RHIC. INRODUCTION RHIC has exceeded designed beam intensities and
Calcium Requirements of Various Species of Azotobacter. (1960)

Calcium ion requirements of strains representing 5 species of the Azotobacteriace have been studied. Quantitative differences in growth response on molecular nitrogen and on urea-N were readily detected with strains of A. vinelandii and A. chroococum and less definitely with A. beijerinckii and possibly A. macrocytogenes. No specific requirement for calcium was detected with strains of A. agilis, and the ion inhibited growth of A. indicus on either source of nitrogen. Acetate and ethanol replaced the calcium required for nitrogen fixation by 3 strains of A. vinelandii tested.
<b>Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem </b><b>cells </b> (2015)

Induced pluripotent stem cells (iPSCs) are a promising cell source for cartilage regenerative medicine. Meanwhile, the risk of tumorigenesis should be considered in the clinical application of human iPSCs (hiPSCs). Here, we report in vitro chondrogenic differentiation of hiPSCs and maturation of the differentiated hiPSCs through transplantation into mouse knee joints. Three hiPSC clones showed efficient chondrogenic differentiation using an established protocol for human embryonic stem cells. The differentiated hiPSCs formed hyaline cartilage tissues at 8 weeks after transplantation into the articular cartilage of NOD/SCID mouse knee joints. Although tumors were not observed during the 8 weeks after transplantation, an immature teratoma had developed in one mouse at 16 weeks. In conclusion, hiPSCs are a potent cell source for regeneration of hyaline articular cartilage. However, the risk of tumorigenesis should be managed for clinical application in the future.
Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats (2019)

Background We previously reported that vascular smooth muscle cells ( VSMC s) from spontaneously hypertensive rats ( SHR s) show the increased expression of complement 3 (C3) and the synthetic phenotype. We targeted the SHR C3 gene (C3 knockout [C3 KO] SHRs ) by the zinc finger gene editing method. In the current study, we investigated the mechanisms underlying the increased expression of C3 and the role of endogenous C3 in the synthetic phenotype of SHR VSMC s in comparison to cells from Wistar-Kyoto ( WKY) rats and C3 KO SHR s. Methods and Results Nonmuscle myosin heavy chain staining of aortas from SHR s at 1 day after birth was stronger in comparison to WKY rats and C3 KO SHR s. DNA synthesis in VSMC s from SHR s was significantly higher in comparison to WKY rats and C3 KO SHR s. Immunohistochemical staining of renin and liver X receptor α in VSMC s from SHR s was stronger in comparison to WKY rats and C3 KO SHR s. The expression of renin, Krüppel-like factor 5, and liver X receptor α proteins in VSMC s from SHR s was significantly higher in comparison to WKY rats and C3 KO SHR s. The expression of synthetic phenotype markers osteopontin, matrix gla, and l-caldesmon, growth factors transforming growth factor-β1 and platelet-derived growth factor-A, transcription factors Krüppel-like factor 5 and liver X receptor α, and angiotensinogen mRNA s in VSMC s from SHR s was significantly higher in comparison to WKY rats and C3 KO SHR s. The expression of miR-145 mRNA in VSMC s from SHR s was suppressed in comparison to cells from WKY rats. miR-145 inhibitor significantly increased the expression of C3 in VSMC s from WKY rats, but not in cells from SHR s. Conclusions These findings indicate that the increased C3 with the suppression of miR-145 induces the synthetic phenotype through Krüppel-like factor 5 and the activation of the renin-angiotensin system through liver X receptor α in VSMC s from SHR s.
Effects of near-surface defects on the optical, electrical and magnetic properties of ZnO films (2014)

We studied the optical, electrical and magnetic properties of ZnO films prepared by using a pulsed laser deposition method. Low-temperature photoluminescence (PL) measurements revealed a strong emission line at 3.333 eV. A dependence of this emission intensity on oxygen adsorbed on the surface was observed, indicating a near-surface origin for the emission. The transition at 3.333 eV was attributed to bound exciton, and the observed anomalously small thermal activation energy in comparison with the localization energy could be explained by a modification of the surface state. The observed resistance switching effect and ferromagnetism in the ZnO films were related to the existence of defects responsible for the PL emission at 3.333 eV.
Cytotoxic Arylnaphthalene Lignans from a Vietnamese Acanthaceae, Justicia patentiflora (2005)

One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.
Diagnosis of Obstructive Sleep Apnea during Wakefulness Using Upper Airway Negative Pressure and Machine Learning (2019)

Background and Rational: Obstructive Sleep Apnea (OSA) is a common disorder, affecting almost 10% of adults, but very underdiagnosed. This is largely due to limited access to overnight sleep testing using polysomnography (PSG). Our goal was to distinguish OSA from healthy individual using a simple maneuver during wakefulness in combination with machine learning methods. Methods: Participants have undergone an overnight PSG to determine their ground truth OSA severity. Separately, they were asked to breathe through a nasal mask or a mouth piece through which negative pressure (NP) was applied, during wakefulness. Airflow waveforms were acquired and several features were extracted and used to train various classifiers to predict OSA. Results and Discussion: The performance of each classifier and experimental setup was calculated. The best results were obtained using Random Forest classifier for distinguishing OSA from healthy individuals with a very good area under the curve of 0.80. To the best of our knowledge, this is the first study to deploy machine learning and NP with promising path to diagnose OSA during wakefulness.
Hydrodynamic Behavior of a Filter-Press Electrochemical Reactor with Carbon Felt As a Three-Dimensional Electrode (1998)

The implementation of three-dimensional electrodes in electrochemical reactors provides an effective method to improve the efficiency of some electrochemical processes, such as wastewater treatment, electrosynthesis, and energy storage. The increase of the surface area due to the high porosity of these materials is of special interest in diffusion−convection controlled processes. The flow distribution inside the reactor compartments is highly influenced by the characteristics of the porous material. The hydrodynamic behavior of a filter-press electrochemical reactor assembled with three-dimensional electrodes made of carbon felt has been studied in this paper. The felt thickness/cell thickness ratio has been optimized on the basis of flow distribution and energetic considerations, such as pumping power and electrode−collector contact losses.
All-optical InP-monolithically integrated WDM regenerator for PoISK signals (2012)

A monolithically integrated Indium Phosphide optical circuit performing WDM regeneration of Polarization Shift Keying signals is presented. The scheme is based on hardlimiting amplification in a saturated Semiconductor Optical Amplifier. A Q-factor improvement of around 2 is reported on two different wavelengths.
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity (2021)

Studying latent Mycobacterium tuberculosis (Mtb) infection has been limited by the lack of a suitable mouse model. We discovered that transient depletion of biotin protein ligase (BPL) and thioredoxin reductase (TrxB2) results in latent infections during which Mtb cannot be detected but that relapse in a subset of mice. The immune requirements for Mtb control during latency, and the frequency of relapse, were strikingly different depending on how latency was established. TrxB2 depletion resulted in a latent infection that required adaptive immunity for control and reactivated with high frequency, whereas latent infection after BPL depletion was independent of adaptive immunity and rarely reactivated. We identified immune signatures of T cells indicative of relapse and demonstrated that BCG vaccination failed to protect mice from TB relapse. These reproducible genetic latency models allow investigation of the host immunological determinants that control the latent state and offer opportunities to evaluate therapeutic strategies in settings that mimic aspects of latency and TB relapse in humans.
Motion-based recognition of people in EigenGait space (2003)

A motion-based, correspondence-free technique or human gait recognition in monocular video is presented. We contend that the planar dynamics of a walking person are encoded in a 2D plot consisting of the pairwise image similarities of the sequence of images of the person, and that gait recognition can be achieved via standard pattern classification of these plots. We use background modelling to track the person for a number of frames and extract a sequence of segmented images of the person. The self-similarity plot is computed via correlation of each pair of images in this sequence. For recognition, the method applies principal component analysis to reduce the dimensionality of the plots, then uses the k-nearest neighbor rule in this reduced space to classify an unknown person. This method is robust to tracking and segmentation errors, and to variation in clothing and background. It is also invariant to small changes in camera viewpoint and walking speed. The method is tested on outdoor sequences of 44 people with 4 sequences of each taken on two different days, and achieves a classification rate of 77%. It is also tested on indoor sequences of 7 people walking on a treadmill, taken from 8 different viewpoints and on 7 different days. A classification rate of 78% is obtained for near-fronto-parallel views, and 65% on average over all view.