gebhart/patrepeval huggingface dataset:
Effect of Temperature on Cutting Production of 10 Hanging-Basket Crops (1998)

Stock plants of Argeranthemum frutescens `Butterfly' and `Sugar Baby', Brachycome hybrid `Ultra', Helichrysum bracteatum `Golden Beauty', Scaevola aemula `New Wonder', Petunia axillaris hybrids `Purple Sunsport' and `Blue Vein', Sutera cordata `Mauve Mist' and `Snowflake', and Verbena hybrid `Blue' were grown in glass greenhouses under five different temperatures (17, 20, 23, 26, or 29 °C) and a 13-h photoperiod. Cuttings were taken two to three times per week. Total cutting production increased as temperature increased. However, different varieties showed different temperature response patterns. Cutting production in Argeranthmum and Brachycome was relatively insensitive to temperature. For Brachycome, Helichrysum, Scaevola, Petunia, Sutera, and Verbena , cutting production in the 29 °C treatment was double or triple that in the 17 °C treatment. For all tested species, the highest cutting production was in the 29 °C treatment. Although cuttings produced in the 29 °C treatment tended to have a soft stem, rooting was not affected by temperature under which stock plants were grown.
Optical fibre sensing during critical care (2017)

Optical fibre sensing is a platform technology for applications in biomedical and environmental monitoring. Fibre Bragg Gratings can be used to monitor parameters such as pressure and temperature. Alternatively, coating the fibres with functional layers, either at the tip of the fibre, on a U-shaped fibre, or a long period grating enables sensing of analytes in liquids and gases. This paper describes the application of optical fibre sensing techniques during mechanical ventilation via an endotracheal tube in critical care. Functional coatings on the fibres are used to monitor humidity of inspired air and can be used to monitor other analytes.
CiC3-1a-Mediated Chemotaxis in the Deuterostome Invertebrate Ciona intestinalis (Urochordata) (2003)

Deuterostome invertebrates possess complement genes, and in limited instances complement-mediated functions have been reported in these organisms. However, the organization of the complement pathway(s), as well as the functions exerted by the cloned gene products, are largely unknown. To address the issue of the presence of an inflammatory pathway in ascidians, we expressed in Escherichia coli the fragment of Ciona intestinalis C3-1 corresponding to mammalian complement C3a (rCiC3-1a) and assessed its chemotactic activity on C. intestinalis hemocytes. We found that the migration of C. intestinalis hemocytes toward rCiC3-1a was dose dependent, peaking at 500 nM, and was specific for CiC3-1a, being inhibited by an anti-rCiC3-1a-specific Ab. As is true for mammalian C3a, the chemotactic activity of C. intestinalis C3-1a was localized to the C terminus, because a peptide representing the 18 C-terminal amino acids (CiC3-1a(59-76)) also promoted hemocyte chemotaxis. Furthermore, the CiC3-1a terminal Arg was not crucial for chemotactic activity, because the desArg peptide (CiC3-1a(59-75)) retained most of the directional hemocyte migration activity. The CiC3-1a-mediated chemotaxis was inhibited by pretreatment of cells with pertussis toxin, suggesting that the receptor molecule mediating the chemotactic effect is G(i) protein coupled. Immunohistochemical analysis with anti-rCiC3-1a-specific Ab and in situ hybridization experiments with a riboprobe corresponding to the 3'-terminal sequence of CiC3-1, performed on tunic sections of LPS-injected animals, showed that a majority of the infiltrating labeled hemocytes were granular amebocytes and compartment cells. Our findings indicate that CiC3-1a mediates chemotaxis of C. intestinalis hemocytes, thus suggesting an important role for this molecule in inflammatory processes.
Dual Targeting of Norepinephrine Transporter (NET) Function and Thyrointegrin αvβ3 Receptors in the Treatment of Neuroblastoma (2020)

Therapeutic targeting of the norepinephrine transporter (NET) function with benzylguanidine (BG), conjugated with the high-affinity thyrointegrin αvβ3 antagonist triazole tetraiodothyroacetic acid, TAT, via noncleavable bonding to poly(ethylene glycol) (PEG<sub>400</sub>) (P) might allow for effective treatment options in neuroblastoma. BG-P-TAT is a dual-targeting agent, targeting the NET function and the thyrointegrin αvβ3 receptors that are overexpressed in neuroblastoma and other neuroendocrine tumors. Various cancer cells and actively dividing tumor-endothelial cells express the thyrointegrin αvβ3 receptors. In this work, the novel compound BG-P-TAT was synthesized and evaluated in the neuroblastoma SK-N-FI cell line for improved targeting and to offer a new strategy for patients with neuroblastoma. BG-P-TAT demonstrated significant suppression of neuroblastoma tumor progression, growth, and viability in a dose-dependent manner. In conclusion, BG-P-TAT represents a potential lead candidate for the treatment of neuroblastoma and other neuroendocrine tumors.
Die fundamentalen Kräfte (1996)

Den überzeugendsten Beweis ihrer Fähigkeit zur Vereinheitlichung erbringt die Physik, indem sie alle Phänomene der Natur mit Hilfe von nur vier fundamentalen Kräften beschreibt. Von diesen sind uns zwei geläufig, die Schwerkraft und die elektromagnetische Kraft; die beiden anderen, die Schwache und die Starke Kernkraft (meistens kurz Schwache und Starke Kraft genannt), sind es weniger. Noch erstaunlicher ist, daß unser Alltag nur von den ersten beiden bestimmt wird, von der Schwerkraft und vom Elektomagnetismus, weil nur sie einen Einfluß von makroskopischer Reichweite besitzen. Die Schwache und die Starke Kraft wirken nur bis zu einem Abstand von maximal 10-15 m um ihrem Ursprung herum.
Mechanical stiffness and anisotropy measured by MRE during brain development in the minipig (2023)

The relationship between brain development and mechanical properties of brain tissue is important, but remains incompletely understood, in part due to the challenges in measuring these properties longitudinally over time. In addition, white matter, which is composed of aligned, myelinated, axonal fibers, may be mechanically anisotropic. Here we use data from magnetic resonance elastography (MRE) and diffusion tensor imaging (DTI) to estimate anisotropic mechanical properties in six female Yucatan minipigs at ages from 3 to 6 months. Fiber direction was estimated from the principal axis of the diffusion tensor in each voxel. Harmonic shear waves in the brain were excited by three different configurations of a jaw actuator and measured using a motion-sensitive MR imaging sequence. Anisotropic mechanical properties are estimated from displacement field and fiber direction data with a finite element- based, transversely-isotropic nonlinear inversion (TI-NLI) algorithm. TI-NLI finds spatially resolved TI material properties that minimize the error between measured and simulated displacement fields. Maps of anisotropic mechanical properties in the minipig brain were generated for each animal at all four ages. These maps show that white matter is more dissipative and anisotropic than gray matter, and reveal significant effects of brain development on brain stiffness and structural anisotropy. Changes in brain mechanical properties may be a fundamental biophysical signature of brain development.
Reconfigurable spatially-periodic umbilical defects in nematic liquid crystals enabled by self-organization (2023)

Abstract Spontaneous formation of ordered structures is observed in many physical systems. Soft materials such as colloids, polymers, and liquid crystals (LCs) are stimuli-responsive and often form various functional self-organized structures that are interesting not only fundamentally but also regarding applications. Nematic LCs (NLCs) consisting of elongated molecules are characterized by anisotropic molecular orientations that are strongly affected by external fields. In particular, the combination of an applied electric field and surface boundary conditions is commonly used for controlling stable configurations and plays a fundamental role in LC devices. Currently, the standard approach to fabricating complex molecular orientations is to use tailored surfaces that mostly rely on top-down lithographic techniques, with relatively few examples of bottom-up systems that produce patterned structures. Moreover, previously known systems such as electroconvection are quite dynamic and not sufficiently controllable, even though they exhibit a variety of patterns. Therefore, exploring the physical mechanism for the formation of a spontaneous pattern could be important in exploiting the further functional properties of NLCs. Here, we briefly review a unique type of self-organization in NLCs induced by an electric field, where the crucial effects of the polymer layer between the NLC and the electrodes lead to the formation of a two-dimensional periodic structure in the sample cell instead of the standard reorientation process. As well as experimental demonstration of the phenomenon, a descriptive theoretical framework is discussed, as are perspectives for optical applications.
Chaos and nonlinear dynamics of single‐particle orbits in a magnetotaillike magnetic field (1986)

The properties of charged‐particle motion in Hamiltonian dynamics are studied in a magnetotaillike magnetic field configuration. It is shown by numerical integration of the equation of motion that the system is generally nonintegrable and that the particle motion can be classified into three distinct types of orbits: bounded integrable orbits, unbounded stochastic orbits, and unbounded transient orbits. It is also shown that different regions of the phase space exhibit qualitatively different responses to external influences. The concept of “differential memory” in single‐particle distributions is proposed. Physical implications for the dynamical properties of the magnetotail plasmas and the possible generation of non‐Maxwellian features in the distribution function are discussed.
Highly reconfigurable hybrid laser based on an integrated nonlinear waveguide (2019)

The ability of laser systems to emit different adjustable temporal pulse profiles and patterns is desirable for a broad range of applications. While passive mode-locking techniques have been widely employed for the realization of ultrafast laser pulses with mainly Gaussian or hyperbolic secant temporal profiles, the generation of versatile pulse shapes in a controllable way and from a single laser system remains a challenge. Here we show that a nonlinear amplifying loop mirror (NALM) laser with a bandwidth-limiting filter (in a nearly dispersion-free arrangement) and a short integrated nonlinear waveguide enables the realization and distinct control of multiple mode-locked pulsing regimes (e.g., Gaussian pulses, square waves, fast sinusoidal-like oscillations) with repetition rates that are variable from the fundamental (7.63 MHz) through its 205<sup>th</sup> harmonic (1.56 GHz). These dynamics are described by a newly developed and compact theoretical model, which well agrees with our experimental results. It attributes the control of emission regimes to the change of the NALM response function that is achieved by the adjustable interplay between the NALM amplification and the nonlinearity. In contrast to previous square wave emissions, we experimentally observed that an Ikeda instability was responsible for square wave generation. The presented approach enables laser systems that can be universally applied to various applications, e.g., spectroscopy, ultrafast signal processing and generation of non-classical light states.
The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility (1992)

The conditionally lethal lpxA2 mutant of Escherichia coli, which lacks detectable UDP-N-acetylglucosamine acyltransferase activity and which produces greatly reduced amounts of lipid A after a shift to 42 degrees C (S. Galloway and C. R. H. Raetz, J. Biol. Chem. 265:6394-6402, 1990), was found to be, at conditions which promote normal growth, remarkably susceptible to a number of antibiotics. The MICs of hydrophobic antibiotics, such as rifampin, erythromycin, clindamycin, and fusidic acid, were 32- to greater than 128-fold lower for the lpxA2 strain than for the parent type strain, and those of the peptide antibiotics vancomycin and bacitracin were 32- and 256-fold lower, respectively. Futhermore, the lpxA2 strain was found to be sensitive to hypoosmotic conditions. Comparisons with the other characterized outer membrane permeability mutants, such as the heptose-deficient strains of E. coli and Salmonella typhimurium, the acrA and abs mutants of E. coli, and the ssc-1 and class SS-B mutants of S. typhimurium, indicated that the lpxA2 mutant had characteristically the most antibiotic-supersusceptible phenotype. These findings advocate the possible use of the lpxA2 strain as a tool in various fields of basic and applied bacterial research in which the impermeability of the outer membrane currently poses problems.
How large should a digital desk be? (2000)

Qualitative results are presented of a user study comparing a large digital desk with stylus, a digital tablet with stylus, and a standard monitor and mouse. Participants split preferences over the desk and the tablet for a sketching task, but generally preferred the monitor and mouse for an image sorting task. Participants did not object to the relatively lower resolution of the images on the digital desk. Several participants found the surface of the desk to be too large and the tablet to be too small, suggesting that either an intermediate size display is preferable, or that interfaces designed for large work surfaces should focus on putting primary information near the user and less important information in the periphery.
Regulation of Polyhydroxybutyrate Synthesis in the Soil Bacterium Bradyrhizobium diazoefficiens (2016)

Polyhydroxybutyrate (PHB) is a carbon and energy reserve polymer in various prokaryotic species. We determined that, when grown with mannitol as the sole carbon source, Bradyrhizobium diazoefficiens produces a homopolymer composed only of 3-hydroxybutyrate units (PHB). Conditions of oxygen limitation (such as microoxia, oxic stationary phase, and bacteroids inside legume nodules) were permissive for the synthesis of PHB, which was observed as cytoplasmic granules. To study the regulation of PHB synthesis, we generated mutations in the regulator gene phaR and the phasin genes phaP1 and phaP4 Under permissive conditions, mutation of phaR impaired PHB accumulation, and a phaP1 phaP4 double mutant produced more PHB than the wild type, which was accumulated in a single, large cytoplasmic granule. Moreover, PhaR negatively regulated the expression of phaP1 and phaP4 as well as the expression of phaA1 and phaA2 (encoding a 3-ketoacyl coenzyme A [CoA] thiolases), phaC1 and phaC2 (encoding PHB synthases), and fixK2 (encoding a cyclic AMP receptor protein [CRP]/fumarate and nitrate reductase regulator [FNR]-type transcription factor of genes for microoxic lifestyle). In addition to the depressed PHB cycling, phaR mutants accumulated more extracellular polysaccharides and promoted higher plant shoot dry weight and competitiveness for nodulation than the wild type, in contrast to the phaC1 mutant strain, which is defective in PHB synthesis. These results suggest that phaR not only regulates PHB granule formation by controlling the expression of phasins and biosynthetic enzymes but also acts as a global regulator of excess carbon allocation and symbiosis by controlling fixK2 IMPORTANCE: In this work, we investigated the regulation of polyhydroxybutyrate synthesis in the soybean-nodulating bacterium Bradyrhizobium diazoefficiens and its influence in bacterial free-living and symbiotic lifestyles. We uncovered a new interplay between the synthesis of this carbon reserve polymer and the network responsible for microoxic metabolism through the interaction between the gene regulators phaR and fixK2 These results contribute to the understanding of the physiological conditions required for polyhydroxybutyrate biosynthesis. The interaction between these two main metabolic pathways is also reflected in the symbiotic phenotypes of soybeans inoculated with phaR mutants, which were more competitive for nodulation and enhanced dry matter production by the plants. Therefore, this knowledge may be applied to the development of superior strains to be used as improved inoculants for soybean crops.
Interaction of a hydrophobic model peptide and its fatty acid derivative with lipid vesicles (1988)

The interaction of a peptide [Lys-Phe-Phe-Phe-Ile-Ile-Trp-OCH3] and its fatty acid derivatives [Lys-(epsilon-palmitoyl)-Phe-Phe-Phe-Ile-Ile-Trp-OCH3 and Lys-(epsilon-12-(9-anthroyloxy)stearic acid)-Phe-Phe-Phe-Ile-Ile-OCH3] with model membranes was investigated by fluorescence spectroscopy. The emission characteristics of the Trp fluorophore indicated that only the peptide with the fatty acid chain is associated with lipid vesicles. Quenching experiments with spin probes suggest an orientation for the fatty acylated peptide wherein the fatty acid chain is perpendicular to the bilayer surface and the peptide chain parallel to the bilayer surface.
Ascorbic Acid Technology in Agricultural, Pharmaceutical, Food, and Industrial Applications (1982)

Ascorbic acid, as well as its salts and esters, has many useful applications. In plants L-ascorbic acid has been reported to promote germination of seeds, growth of plants, and growth of roots on cuttings. Spraying of plants such as lettuce, celery, spinach, petunias, and roses with ascorbic acid or sodium ascorbate solutions enabled those plants to better withstand damage from ozone and smog exposure. Spraying tree or bush fruits with ascorbic acid solution synchronizes maturation and causes fruit to fall more easily in mechanical harvesting. In some instances ascorbic acid application has been cited to improve the defense mechnism of plants to attack by disease agents. Fish require a dietary source of vitamin C, without which they grow poorly and develop fracture dislocations of the spine, distortions of cartilage, and other deficiency signs. In some instances, ruminants and monogastric animals appear to benefit from administration of L-ascorbic acid under stress. Animals with viral disease, such as canine or feline distemper, have responded to treatment with high levels of ascorbic acid. Solid and liquid forms constitute a substantial pharmaceutical market for manufactured ascorbic acid. Tableting techniques have been devised to prepare a wide array of swallowable or chewable tablets with an assured vitamin C content after manufacture and prolonged storage. L-Ascorbic acid may be added to foods or food ingredients as a nutrient to fortify natural or fabricated foods having little or no vitamin C, to restore losses, and to standardize a given class of food products with a preselected quantity of the vitamin. Factors that must be considered with appropriate technology before adding ascorbic acid are the following: (i) cost of the specific food; (ii) convenience of use; (Hi) relationship of the food in question to normal food selection or to replacement or supplemental food products; (iv) stability of the vitamin in the food during shelf life and home preparation; (v) public health considerations; and (vi) special food needs, such as infant, geriatric, and military. In addition to serving as an added nutrient in food, L-ascorbic acid is often used as a processing aid or as a preservative in certain foods or food ingredients. Examples include preventing enzymatic browning of cut fruit, scavenging oxygen in beer, fruit, or vegetable products, inhibiting oxidative rancidity in frozen fish, stabilizing the color and flavor in cured meats, maturing of wheat flour and improving of dough, and acting as a reducing agent in wine. An extensive list of patents and scientific papers exists on proposed industrial uses of ascorbic acid. The greatest interest appears to be in the synthetic polymer industry, in photoprocessing, and in metal technology. Miscellaneous uses have been proposed in cosmetics, tobacco, fibers, preservation of blood, preservation of cut plants, cleaning agents, and in assay reagents.
Enantioselective epoxidation of unfunctionalized olefins catalyzed by salen manganese complexes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective epoxidation of unfunctionalized olefins catalyzed by salen manganese complexesWei Zhang, Jennifer L. Loebach, Scott R. Wilson, and Eric N. JacobsenCite this: J. Am. Chem. Soc. 1990, 112, 7, 2801–2803Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00163a052https://doi.org/10.1021/ja00163a052research-articleACS PublicationsRequest reuse permissionsArticle Views18362Altmetric-Citations1435LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Data from Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial) (2023)

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Preclinical evaluation of the Versius surgical system: A next‐generation surgical robot for use in minimal access prostate surgery (2023)

This study provides a preclinical assessment of a next-generation surgical robot for prostatectomies. All procedures were completed successfully, and port and BSU positions were validated, thus supporting the progression of the system to further clinical development according to the IDEAL-D framework.
Fabrication of Ceramic-Ceramic Composites by Chemical Vapor Deposition (2008)

Toughened ceramic composites were produced by the simultaneous chemical vapor deposition of two phases. Fracture toughness values were nearly double the value of SiC when CH3SiCl3 and TiCl4 vapors were used to produce SiC-TiSi2 composites. Other systems consisting of SiC and the metal or metal carbides of Ni, Cr, W, and Mo were examined. Equilibrium thermodynamic analyses of these systems were performed as a function of the chemical vapor deposition variables: temperature, total pressure, and reactant concentration. These calculations confirmed that the volatile species used early in this work (organometallic compounds of Ni and Cr and the fluorides of W and Mo) were not suitable for the production of toughened composites. Additional work is under way to produce composites from the oxy- chlorides or carbonyls of Ni and Cr or the chlorides or oxychlorides of W and Mo. Thermodynamic calculations also indicated that SiC and TiC should be codeposited when CH3SiCl3, TiCl4, and a hydrocarbon are used as the coating gases. Much additional work remains to produce SiC-TiC composites and to control the morphology of the TiSi, dispersed phase so that optimum fracture toughness values can be obtained.