gebhart/patrepeval huggingface dataset:
The INTERNET STUDY: A phase II study of everolimus in patients with fluorodeoxyglucose (18F) positron‐emission tomography positive intermediate grade pancreatic neuroendocrine tumors (2020)

Everolimus is active with prolonged disease control in poor prognosis FDG-avid G2 PNETs. Treatment individualization based on functional imaging warrants further evaluation.
Changes in the intestinal bacterial community, short-chain fatty acid profile, and intestinal development of preweaned Holstein calves. 1. Effects of prebiotic supplementation depend on site and age (2016)

Digestive disorders are common during the first few weeks of life of newborn calves. Prebiotics are nondigestible but fermentable oligosaccharides that modulate growth and activity of beneficial microbial populations, which can result in enhanced gut health and function. Galactooligosaccharides (GOS) have demonstrated such prebiotic potential. In this study, the effect of GOS supplementation on intestinal bacterial community composition and fermentation profiles; intestinal health, development, and function; and growth was evaluated in dairy calves fed for high rates of growth. Eighty male Holstein calves were assigned either to a control treatment consisting of commercial milk replacer or to a GOS-rich (i.e., 3.4% of dry matter) milk replacer treatment. After 2 and 4wk, 8 calves per treatment were slaughtered at each age. Samples of intestinal digesta and tissue were collected for assessment of bacterial communities, short-chain fatty acid concentrations, in vitro measurement of nutrient transport and permeability, histomorphology, and gastrointestinal organ size. The remaining 48 calves continued to wk 8 to measure body growth, nutrient intake, and fecal and respiratory scores. Calves fed GOS displayed greater Lactobacillus and Bifidobacterium relative abundance and more developed intestinal epithelial structures, but also had greater fecal scores presumably related to greater colonic water secretion. Control calves showed slightly better growth and milk dry matter intake. Size of intestinal organs, intestinal nutrient transport, and epithelium paracellular resistance were not affected by treatment. Excessive GOS supplementation had both prebiotic and laxative effects, which led to slightly lower growth performance while promoting commensal bacteria population and greater intestinal epithelium growth.
Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists (2018)

Histamine H<sub>3</sub> receptor (H<sub>3</sub>R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H<sub>3</sub>R antagonists based on the iso-flavone scaffold. The results of the bioactivity evaluation show that four compounds (1c, 2c, 2h, and 2o) possess significant H<sub>3</sub>R inhibitory activities. Molecular docking indicates that a salt bridge, π-π T-shape interactions, and hydrophobic interaction all contribute to the interaction between compound 2h and H<sub>3</sub>R.
Up-regulation of Endogenous RGS2 Mediates Cross-desensitization between Gs and Gq Signaling in Osteoblasts (2006)

Regulator of G protein signaling (RGS) proteins limit G protein signals. In this study, we investigated the role of RGS2 in the control of G protein signaling cascades in osteoblasts, the cells responsible for bone formation. Expression of RGS2 was up-regulated in primary cultures of mouse calvarial osteoblasts by parathyroid hormone-related peptide (PTHrP)-(1-34), which stimulates G(s) signaling. RGS2 was also up-regulated by extracellular ATP, which selectively activates G(q), as well as by forskolin and phorbol myristate acetate, which activate targets downstream of G(s) and G(q), respectively. To assess the role of endogenous RGS2, we characterized G(s) and G(q) signaling in osteoblasts derived from wild type and rgs2(-/-) mice. Under control conditions, nucleotide-stimulated calcium release, endothelin-stimulated accumulation of inositol phosphates, and PTHrP-stimulated cAMP accumulation were equivalent in osteoblasts isolated from wild type and rgs2(-/-) mice. Thus, basal levels of endogenous RGS2 do not appear to regulate G(s) or G(q) signaling in osteoblasts. Interestingly, forskolin treatment of wild type but not rgs2(-/-) osteoblasts suppressed both endothelin-stimulated accumulation of inositol phosphates and nucleotide-stimulated calcium release, indicating that up-regulation of RGS2 by G(s) signaling desensitizes G(q) signals. Furthermore, pretreatment with ATP suppressed PTHrP-dependent cAMP accumulation in wild type but not rgs2(-/-) osteoblasts, implying that up-regulation of RGS2 by G(q) signaling desensitizes G(s) signals. Our findings demonstrate that endogenously expressed RGS2 can limit G(s) signaling. Moreover, up-regulation of RGS2 contributes to cross-desensitization of G(s)- and G(q)-coupled signals.
Media access protocols for high speed data bus-a simulation study (2003)

The authors discuss a high-speed data bus for satellite (HSDB-S) architecture and evaluate media access control (MAC) protocols. They simulated the fiber distributed data interface (FDDI) protocol, which is applicable to HSDB, for asynchronous and synchronous traffic in terms of throughput, delay, queue length, and station latency. They propose a deferred priority protocol and compare throughput-delay performance with preemptive priority and normal (FDDI) priority protocols. The deferred priority protocol is shown to provide better throughput than the preemptive priority protocol, but results in less delay performance for highest-priority messages. For lowest-priority traffic, the preemptive priority protocol provides the least throughput, and the worst delay performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Experiments with the fiber-connected interferometer for the MIRA project (2000)

Fiber optics is useful for connecting the element telescopes of a long-baseline interferometer. Experiments with a fiber- connected interferometer are carried out as a part of MIRA- I.2 interferometer under construction. MIRA-I.2 is an interferometer consisting of two 300 mm siderostats which are placed on a 30 m south-north baseline. For this baseline, it is necessary to use fibers of about 100 m long. Fiber optics will be essential for the interferometric connection of large telescopes, such as Subaru, Gemini, and Keck on the summit of Mauna Kea. In this case, fiber length of about 1 km is needed. We achieved white light fringes using 10 m and 100 m fibers. With the 10 m fiber, visibility of 0.7 was achieved for both He-Ne laser and white light sources. Visibility of 0.7 for white light was obtained by compensating the dispersion effect of fiber with glass plates. Experiments will be extended to longer fibers such as 1000 m.
Nondestructive evaluation of steam turbine rotors: an analysis of the systems and techniques utilized for in-service inspection. Interim report (1978)

The discontinuities present in large steam turbine rotor forgings and their growth during service are of major concern since failures of these rotors are extremely expensive both in potential loss of lives and revenues. The current inservice inspections of these rotors are thus a significant part of the quality control programs of electric utilities to assure the safe and continued operation of power generating stations. The nature of the NDE processes now being used for rotor inspection and the types of internal indications which are considered technically relevant, from a stress distribution viewpoint are reviewed, and recommendations are made of where rotor examinations can be improved. In particular, the details of boresonic examination procedures are reviewed and the most probable causes of routine inspection uncertainties are identified. Minimum flaw sensitivities are described and the probabilities of detection, based on boresonic axial scan patterns are identified in terms of the measured beam profiles of typical inspection transducers. A set of acceptance criteria to be used with existing inspection systems are suggested. These criteria would require inspection service contractors to demonstrate their system's minimum sensitivity, ultimate depth and spatial resolution, and repeatability by virtue of an ability to repeatedly detect and discriminate between sets of precision holes placed in specified patterns within a recommended universal calibration standard.
Factors Influencing Utilization of Medical Care Among Osteoarthritis Patients in Korea: Using 2005 Korean National Health and Nutrition Survey Data (2010)

The patients who tend to receive less care are those suffer less from symptoms of osteoarthritis, those who are within the initial phase, or those with a low-level severity of osteoarthritis. It is necessary to encourage patients to receive the treatment in the initial phase.
Metabolic and Underlying Causes of Diabetes Mellitus (1982)

It is emphasized that animal models should be used to study specific genotypic or phenotypic expressions associated with diabetes rather than assuming a single animal model can reflect diverse forms of the human disease. Diabetic and normal animals are reviewed on the basis of their usefulness as models of genetic, viral, and chemically induced diabetes, including the often associated immune phenomena. Characteristics of spontaneously diabetic animals with and without obesity are also described with an emphasis on both genetics and metabolic derangements. Recommendations for future animal experimentation include: more longitudinal studies evaluating the role of sex, prenatal environment, diet, and viral or chemical attack on B-cell function; characterization of the immune phenomena associated with B-cell lesions (and insulitis) in diabetic and immunologically incompetent lines; clarification of relationships between obesity and islet-cell function with emphasis on the role of fuel metabolism, vitamins, and minerals; and, finally, the development of new models with specific genetic aberrations placed in normal or diabetic lines.
Patterning: Nanopattern Fabrication of Gold on Hydrogels and Application to Tunable Photonic Crystal (Adv. Mater. 38/2012) (2012)

Nanopattern fabrication of metal dots on a water-swollen hydrogel is performed by transcribing metallic nanodots from a solid substrate to the hydrogel surface. This fabrication technique may stimulate advances in nanoscience using soft, wet matter, enabling development of new ion-based bio-related devices. Au nano-dots on a hydrogel can produce iridescent color, and its spectral response can be finely modulated by controlling the nanodot spacing, as reported by Yoshihito Osada and co-workers on page 5243.
The internal and sphincter--new insights into faecal incontinence. (1991)

The internal anal sphincter -new insights into faecal incontinence Application of neurological techniques to the pelvic floor over the past 10 years has increased our understanding of the pathophysiology ofidiopathic faecal incontinence. 1-7 We now realise that damage to the innervation of the striated external anal sphincter and puborectalis muscles leads to progressive denervation with muscle fibrosis and weakness. These abnormalities can be shown clinically using manometry, measurement of the conduction time of the innervating nerves, and electromyography with either concentric or on July 23, 2023 by guest.
New Use for an Old Clamp (1980)

<i>To the Editor</i>.—Most partial occlusion vascular clamps used for end-to-side infrarenal aortic anastomoses will not reliably control bleeding unless the base, or heel, of the clamp is directed cephalad. This clamp position requires the handle of the clamp to protrude from the upper end of the wound. An assistant must retract the superior end of the incision, and steady the handle of the clamp. Furthermore, the handle of the clamp interferes with the suturing at the cephalad end of the anastomosis. We have found that the Ochsner partial occlusion aortic clamp (Codman Shurtleff Co, Randolph, Mass), which was designed for proximal aortocoronary anastomoses, is ideally suited for end-to-side aortofemoral grafting (Figure). The jaws are sufficiently heavy, so that no blood loss occurs even with the heel of the clamp directed caudad. The depth of the jaws is adequate to permit an oblique end-to-side anastomosis with even the largest aortic
Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts (1997)

Normal fibroblasts cultured as monolayers secrete matrix metalloproteinases (MMP), including gelatinase A (72-kDa type IV collagenase) as inactive zymogens. Previously we found that normal fibroblasts cultured in a type I collagen lattice (dermal equivalent) secrete active gelatinase A. Here we show that the activation of progelatinase A occurs within the cell and that the activator copurifies with Golgi membranes. Cell extracts of fibroblasts cultured in collagen lattices contain active 62-kDa gelatinase A at least 4-6 h before active enzyme is detected in the culture medium. Pulse-chase experiments confirm these results. The activator is membrane-bound and localizes to the Golgi-enriched fraction. Highly purified plasma membranes from lattice cultures are unable to convert gelatinase A from the zymogen to its active form. The activator may be a metalloproteinase because EDTA prevents activation of exogenous proenzyme by membrane fractions. Membrane-type MMP1, the enzyme thought to be responsible for activation of gelatinase A on the plasma membrane of tumor cells, shows no significant change in either mRNA or protein levels during lattice culture. Intracellular levels of gelatinase A mRNA and protein increase during the culture period, and tissue inhibitor of metalloproteinases concentration does not change. Because of the greater availability of tissue inhibitor of metalloproteinases-free proenzyme as a substrate for the activator, it is possible that membrane-type MMP1 is the activating enzyme. In that case, malignant transformation may involve a change in the localization of the activator to the plasma membrane.
Photochemical conversion of phenyl epoxycinnamate to flavonoids and the synthesis of 2'-hydroxyepoxychalcone (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical conversion of phenyl epoxycinnamate to flavonoids and the synthesis of 2'-hydroxyepoxychalconeV. T. Ramakrishnan and Jacques KaganCite this: J. Org. Chem. 1970, 35, 9, 2898–2900Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://doi.org/10.1021/jo00834a009RIGHTS & PERMISSIONSArticle Views166Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (452 KB) Get e-Alerts Get e-Alerts
Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model (2021)

Public awareness of traumatic brain injury (TBI) in the military increased recently because of the conflicts in Iraq and Afghanistan where blast injury was the most common mechanism of injury. Besides overt injuries, concerns also exist over the potential adverse consequences of subclinical blast exposures, which are common for many service members. A TBI is a risk factor for the later development of neurodegenerative diseases, including Alzheimer disease (AD)-like disorders. Studies of acute TBI in humans and animals have suggested that increased processing of the amyloid precursor protein (APP) toward the amyloid beta protein (Aβ) may explain the epidemiological associations with AD. In a previous study, however, we found in both rat and mouse models of blast overpressure exposure that rather than increasing, rodent brain Aβ42 levels were decreased after acute blast exposure. Here we subjected APP/presenilin 1 transgenic mice (APP/PS1 Tg) to an extended sequence of repetitive low-level blast exposures (34.5 kPa) administered three times per week over eight weeks. If initiated at 20 weeks of age, these repetitive exposures, which were designed to mimic human subclinical blast exposures, reduced anxiety and improved cognition as well as social interactions in APP/PS1 Tg mice, returning many behavioral parameters in APP/PS1 Tg mice to levels of non-transgenic wild type mice. Repetitive low-level blast exposure was less effective at improving behavioral deficits in APP/PS1 Tg mice when begun at 36 weeks of age. While amyloid plaque loads were unchanged, Aβ 42 levels and Aβ oligomers were reduced in the brain of mice exposed to repetitive low-level blast exposures initiated at 20 weeks of age, although levels did not directly correlate with behavioral parameters in individual animals. These results have implications for understanding the nature of blast effects on the brain and their relationship to human neurodegenerative diseases.
The role of the CCL22-CCR4 axis in the metastasis of gastric cancer cells into omental milky spots (2014)

Omental milky spots are a congenial microenvironment for peritoneal free gastric cancer cells to migrate, survive, and establish cell cluster-type metastases. The CCL22-CCR4 axis contributes to this selective infiltration process.
Polarization of Aromatic Heterocyclic Compounds. XCVIII (1952)

The 4, 6-diaminoquinoline is an important intermediate compound in the manufacture of sulfen system pharmaceuticals. Tschitschibabin prepared 4-amino-6-nitroquinoline by the direct nitration of 4-aminoquinoline but it has later been clarified by Jensch and Simpson that the so-called 4-amino-6-nitroquinoline was a mixture of 6-nitro-, 3(?)-nitro- and 3, 6-dinitro compounds. As a result of the simplification of 4-aminoquinoline by the recent discovery of the simple synthetic procedure for 4-nitroquinoline, and by the comparative examination of the nitration of 4-amino- and 4-hydroxy-quinolines with that of their N-oxides, it was found that by preliminary obstruction of the 3-position with an atom which could easily be removed later, such as the bromine, with subsequent nitration with sulfuric and nitric acid at below 10° would give 3-bromo-4-amino-6-nitroquinoline, m.p. 286°, with a good yield. Reduction of this compound will give 4, 6-diaminoquinoline with an yield of 52% against 4-amino-quinoline.
low NOx combustor for automotive ceramic gas turbine - conceptual design (1991)

Three low NOx combustors, i.e. a lean premixing combustor, a rich-lean two stage combustor and a lean diffusion flame combustor, were tested in order to find out a suitable combustion concept for an automotive ceramic gas turbine combustor. The prevaporization-premixing lean combustion was proposed as the most promising candidate to meet Japanese 10 mode regulation for gasoline passenger car.The required conditions for the uniform premixture formation in the prevaporization-premixing tube were achieved by a fine droplet size atomizer and by means of swirl and turbulent generator. Air ratio range, air loading and other dimension criteria in the lean primary combustion zone were also proposed in the present paper.Copyright © 1991 by ASME
Application of Hydrazine Hydrate in the Synthesis of Octa(aminophenyl)silsesquioxane (OAPS) Poss (2013)

Octa(aminophenyl)silsesquioxane (OAPS) was prepared from octaphenyl silsesquioxane (OPS) in two steps, first nitration to obtain Octa(nitrophenyl)silsesquioxane (ONPS) then reduction by using the stable, inexpensive, and readily available hydrazine hydrate as the reducing agent in the presence of Iron(III)Chloride catalyst with a yield of around 87%. Hydrazine is a two-electron reducing agent whereas nitro group is a four-electron reduction process. The activated carbon serves as an adsorbent and electrical conductor enabling the reaction to occur by acting as a mediator between a two-electron reagent and a four-electron process. Adsorption provides a reducing potential and a supply of electrons from many hydrazines making possible the initial four-electron process even though each individual hydrazine is a two-electron donor. The product was characterized by FTIR and 1H NMR. The time period for preparation of ONPS from octaphenyl silsesquioxane was considerably shortened to avoid double nitration of the aromatic rings.
<title>Effects Of Aerosols On Imaging Through The Atmosphere: Spatial Frequency And Wavelength Dependent Effects</title> (1983)

Experiments carried out over diagonal lines of sight through the entire atmosphere support the concept of spatial coherence degradation through forward scattering as described by an aerosol transfer function which strongly affects the wavelength dependence of imaging through the atmosphere. Airborne-particulate size and concentration are affected strongly by wind strength and soil moisture. Changes in weather that result in changes in average particulate size of airborne soil-derived particulates also strongly change the wavelength dependence of resolution through the atmosphere as a result of changes in the wavelength dependence of the scattering coefficient. Knowledge of such effects can therefore permit prediction of spectral regions most suitable for imaging through the atmosphere.
Michael additions catalyzed by transition metals and lanthanides species. A review. Part 1. Transition metals (2005)

in the transition-metal-and lanthanide-catalyzed Michael additions are analyzed. Their scope, limitations, induction of enantioselectivity, and mechanistic features are discussed.