gebhart/patrepeval huggingface dataset:
Implications du système nerveux périphérique dans le syndrome d'apnées du sommeil : le nerf périphérique, un marqueur tissulaire de l'hypoxie intermittente, la neuropathie pharyngée, une cause d'apnées du sommeil, un nouvel outil pour diagnostiquer la neuropathie pharyngée (2001)

A DNA strand can encapsulate a silver molecule to create a nanoscale, aqueous stable chromophore. A protected cluster that strongly fluoresces can also be weakly photolabile, and we describe the laser-driven photochemistry of the green fluorophore C<sub>4</sub>AC<sub>4</sub>TC<sub>3</sub>GT<sub>4</sub>/Ag<sub>10</sub><sup>6+</sup>. The embedded cluster is selectively photoexcited at 490 nm and then bleached, and we describe how the efficiency, products, and route of this photochemical reaction are controlled by the DNA cage. With irradiation at 496.5 nm, the cluster absorption progressively drops to give a photodestruction quantum yield of 1.5 (±0.2) × 10<sup>-4</sup>, ∼10<sup>3</sup>× less efficient than fluorescence. A new λ<sub>abs</sub> = 335 nm chromophore develops because the precursor with 4 Ag<sup>0</sup> is converted into a group of clusters with 2 Ag<sup>0</sup> - Ag<sub>6</sub><sup>4+</sup>, Ag<sub>7</sub><sup>5+</sup>, Ag<sub>8</sub><sup>6+</sup>, and Ag<sub>9</sub><sup>7+</sup>. The 4-7 Ag<sup>+</sup> in this series are chemically distinct from the 2 Ag<sup>0</sup> because they are selectively etched by iodide. This halide precipitates silver to favor only the smallest Ag<sub>6</sub><sup>4+</sup> cluster, but the larger clusters re-develop when the precipitated Ag<sup>+</sup> ions are replenished. DNA-bound Ag<sub>10</sub><sup>6+</sup> decomposes because it is electronically excited and then reacts with oxygen. This two-step process may be state-specific because O<sub>2</sub> quenches the red luminescence from Ag<sub>10</sub><sup>6+</sup>. However, the rate constant of 2.3 (±0.2) × 10<sup>6</sup> M<sup>-1</sup> s<sup>-1</sup> is relatively small, which suggests that the surrounding DNA matrix hinders O<sub>2</sub> diffusion. On the basis of analogous photoproducts with methylene blue, we propose that a reactive oxygen species is produced and then oxidizes Ag<sub>10</sub><sup>6+</sup> to leave behind a loose Ag<sup>+</sup>-DNA skeleton. These findings underscore the ability of DNA scaffolds to not only tune the spectra but also guide the reactions of their molecular silver adducts.
Throughput and fairness properties of asynchronous data transfer methods in the IEEE 802.11 MAC protocol (2002)

To satisfy the needs of wireless data networking, study group 802.11 was formed under IEEE project 802 to recommend an international standard for wireless local area networks (WLANs). A key part of standard are the medium access control (MAC) protocols needed to support asynchronous and time bounded delivery of data frames. We conduct a performance evaluation of the asynchronous data transfer protocols that are a part of the proposed IEEE 802.11 standard taking into account the decentralized nature of communication between stations, the possibility of "capture", and presence of "hidden stations". We compute the system throughput and evaluate the fairness properties of the proposed MAC protocols and evaluate the impact of spatial characteristics on the performance of the system. Further, extensive numerical results are presented.
Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk (2016)

Selenium (Se) is a micronutrient that maintains biological functions through the action of Se containing proteins known as selenoproteins. Due to the known antioxidant effects of Se, supplements containing Se have been on the rise. While Se supplementation may be beneficial for Se deficient populations, few are at risk for Se deficiency due to the transportation of food from Se-rich regions and the rise of Se-enriched foods. Alarmingly, Se supplementation may have adverse effects in people who already receive an adequate Se supply. Specifically, an increased risk of type 2 diabetes has been reported in individuals with high baseline Se levels. However, this effect was restricted to males, suggesting the relationship between Se and glucose homeostasis may be sexually dimorphic. This review will discuss the current understanding of the interaction between Se and glucose homeostasis, including any sex differences that have been described.
Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells (2003)

The intracellular role of placental protein 17b (PP17b)/TIP47 has been controversial, because it is considered to be a protein required for mannose 6-phosphate receptor transport from endosome to trans-Golgi as well as a neutral lipid droplet-associated protein. The similarity between the amino acid sequences of PP17 variants, adipophilin and perilipins, and between their gene structures indicate that PP17b as well as other alternatively spliced PP17 variants belong to the lipid storage droplet protein family, containing also some differentiation factors. Using a specific antibody, PP17b was detected in lipid droplet fractions and co-localized with neutral lipid droplets stained by Nile red, and fluorescently labelled PP17 antibody in HeLa cells with confocal microscopy. PP17b was also detected in milk, associated to milk lipid globule membranes. Cytostatic agents induced apoptosis and PP17b synthesis in HeLa cells, which was significantly inhibited by protein kinase C (PKC) inhibitor, indicating the involvement of NF-kappa B and AP-1 transcription factors in this process, while protein kinase A (PKA) inhibitor had only a modest inhibitory effect. Cell differentiation induced by dibutyryl cyclic AMP or phorbol myristate acetate also increased PP17b synthesis, demonstrating its strong involvement in cell differentiation. PP17b synthesis was higher in M than in G0/G1 phases in control, apoptotic and differentiated cells. This data shows that PP17b is a neutral lipid droplet-associated protein, and its expression is regulated by PKC- and PKA-dependent pathways.
Centralization of Body Fat (2001)

A multitude of widely different conditions are characterized by excess accumulation of central, visceral fat. The background seems to be a frequent or chronic activation of central neuroendocrine and autonomic pathways. This parallel activation is characteristic of an arousal reaction of centres in the lower part of the brain, constructed for adaptation to surrounding pressures in order to maintain homeostasis. The wide-spread occurrence of elevated central body fat masses suggests by itself that vital, common pathways are involved. The associations between central fat and such diverse conditions as heart disease, diabetes, stroke, obesity, hypertension, cancer, depression, anxiety, endocrine disturbances, personality aberrations, alcohol abuse, socioeconomic and psychosocial handicaps, suggest some kind of common, central pathogenetic denominator. It seems likely that this denominator is a central arousal, induced by factors in a competitive, hectic society. Central fat accumulation may be considered mainly as a conveniently observable indicator of a chronic stress exposure to such damaging factors, remaining as outdated survival mechanisms.
The Effect of Serum 25-Hydroxyvitamin D on Serum Ferritin Concentrations: A Longitudinal Study of Participants of a Preventive Health Program (2019)

Various studies have suggested a role of vitamin D in inflammation. However, its effect on ferritin, a biomarker of inflammation, has received relatively little attention. Therefore, we aimed to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with serum ferritin (SF) concentrations, and to examine whether temporal increases in serum 25(OH)D concentrations are paralleled by a reduction in SF concentrations. Data from a community sample of Canadian adults who participated in a preventive health program (<i>n</i> = 6812) were analyzed. During the follow-up, serum 25(OH)D concentrations increased from 80.7 to 115.0 nmol/L whereas SF concentrations decreased from 122.0 to 92.0 µg/L (median follow-up time was 11.67 months). Cross-sectional analyses revealed that compared to participants with 25(OH)D concentrations of <50 nmol/L, those with 25(OH)D concentrations of 75 to <100, 100 to <125, and ≥125 nmol/L had SF concentrations that were 13.00, 23.15, and 27.59 µg/L lower respectively (<i>p</i> < 0.001). Compared to those without temporal improvements in 25(OH)D concentrations between baseline and follow-up, participants who improved their 25(OH)D concentrations with ≥50 nmol/L decreased their SF concentrations with 5.71 µg/L. For participants for whom the increase in 25(OH)D concentrations was less than 50 nmol/L, decreases in SF concentrations were less pronounced and not statistically significant. These observations suggest that despite strong associations between 25(OH)D and SF concentrations, interventions aiming to lower SF concentrations through sun-exposure and vitamin D supplementation should target substantial increases in 25(OH)D concentrations.
Anti-Inflammatory and Antipyretic Activities of Azadirachta indica* (1981)

The anti-inflammatory and antipyretic activities, as well as the acute toxicity of Azadirachta indica (Neem tree) extract were studied. It was found to have a pronounced anti-inflammatory (rat paw oedema) and a fairly good antipyretic effect (pyrogen induced hyperpyrexia in rabbits) . The acute oral toxicity test in mice showed a very low range of approximately 13 g/kg body weight.
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension (2006)

In recent years, the process of the programmed cell death has gained much interest because it has important pathophysiological consequences contributing to the deletion of unwanted cells in the vessel wall, loss of pulmonary smooth muscle cells and therefore in reversing the pulmonary pressure. For the reason that most patients with pulmonary hypertension present with limited reversibility with vasodilators, antiremodeling approach for treatment appears to be feasible. Induction or enhancement of vascular smooth muscle cells apoptosis may be targeted to develop novel therapeutic approaches for pulmonary vascular remodeling in patients with pulmonary hypertension. This review summarizes the current mechanisms, investigate the roles and provide novel insights into the potential therapeutic value of apoptosis in the pulmonary artery remodeling of pulmonary hypertension.
Activation of NF‐κB by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers (1996)

The eukaryotic transcription factor NF-kappaB is activated by a large variety of stimuli. We have recently shown that ER stress, caused by an aberrant accumulation of membrane proteins within this organelle, also activates NF-kappaB. Here, we show that activation of NF-kappaB by ER stress requires an increase in the intracellular levels of both reactive oxygen intermediates (ROIs) and Ca2+. Two distinct intracellular Ca2+ chelators and a panel of structurally unrelated antioxidants prevented NF-kappaB activation by various ER stress-eliciting agents, whereas only antioxidants but not the Ca2+ chelators prevented NF-kappaB activation by the inflammatory cytokine TNF-alpha. Consistent with an involvement of calcium, the ER-resident Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently activated NF-kappaB. Pretreatment with a Ca2+ chelator abrogated this induction. The Ca2+ chelator BAPTA-AM inhibited ROI formation in response to thapsigargin and CPA treatment, suggesting that the Ca2+ increase preceded ROI formation during NF-kappaB activation. The selective inhibitory effect of the drug tepoxalin suggests that the peroxidase activity of cyclooxygenases or lipoxygenases was responsible for the increased ROI production in response to Ca2+ release by thapsigargin.
Computational modeling of age-differences in a visually demanding driving task: vehicle detection (2000)

The visual task of detecting an approaching vehicle was modeled with a neurophysiologically motivated computational vision model, the National Automotive Center-visual perception model (NAC-VPM). The scientific literature documenting age-related changes in early vision was reviewed in relationship to the components of the NAC-VPM, and the model was fit to laboratory data from older observers. The model fit the older observers' data adequately, particularly when the data was partitioned into subsets based on viewing conditions. Model fits were compared to calibrations based on younger observers' data. The calibrations based on older observers were substantially different from calibrations based on younger observers, indicating that the model can capture age-related differences in visual perception. When calibrated to the older adults' data, the model successfully predicted conditions under which vehicle detection was particularly difficult for older adults.
Up‐regulation of [3H]‐des‐Arg10‐kallidin binding to the bradykinin B1receptor by interleukin‐1β in isolated smooth muscle cells: correlation with B1agonist‐induced PGI2production (1994)

1. Binding of the specific bradykinin B1 receptor agonist, [3H]-des-Arg10-kallidin (-KD) was investigated in smooth muscle cells (SMC) isolated from rabbit mesenteric arteries (RMA). 2. [3H]-des-Arg10-KD specifically bound to interleukin-1 (IL-1)-treated RMA-SMC in a saturable fashion with an equilibrium dissociation constant (KD) of 0.3-0.5 nM. The number of binding sites per cell was 20,000-35,000. Kinins inhibited [3H]-des-Arg10-KD binding to RMA-SMC with an order of potency very similar to that observed in typical B1 specific bioassays: des-Arg9-bradykinin (BK) approximately KD >> BK. Furthermore, the B1 receptor antagonist [Leu8]des-Arg9-BK inhibited [3H]-des-Arg10-KD binding with an IC50 of 43 nM as expected for its effect at B1 receptors. The B2 receptor antagonists, NPC 567 and Hoe 140 only affected [3H]-des-Arg10-KD binding at very high concentrations (IC50 = 0.8 microM and IC50 > 10 microM, respectively). 3. Des-Arg9-BK (B1 agonist) and [Hyp3]Tyr(Me)8-BK (B2 agonist) did not induce prostacyclin (PGI2) production by RMA-SMC. Lipopolysaccharide (LPS) treatment of the cells did not affect the B1 agonist response whereas IL-1 beta treatment produced a 7 fold increase in des-Arg9-BK-stimulated PGI2 production. IL-1 beta also stimulated the response to B2 agonists. 4. Des-Arg9-BK-induced PGI2 secretion in IL-1-primed RMA-SMC was mediated by B1 receptors since it was inhibited by [Leu8]des-Arg9-BK (IC50 = 56-73 nM) but not by Hoe 140. High concentrations of NPC 567 (IC5o = 2.4 micro M) were required to inhibit PGI2 production induced by B1 agonists.5. IL- 1-treated RMA-SMC displayed a 5 fold increase in the number of B1 receptors without modification of the affinity constant, thus establishing a possible relationship between the receptor density and the IL-i-primed B1 response.6. LPS treatment of the cells induced a 4 fold increase in B1 receptor number without modifying PGI2 secretion. This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway.
Radical Cyclization of 2-Alkenylthioanilides:  A Novel Synthesis of 2,3-Disubstituted Indoles (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRadical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted IndolesHidetoshi Tokuyama, Tohru Yamashita, Matthew T. Reding, Yosuke Kaburagi, and Tohru FukuyamaView Author Information Graduate School of Pharmaceutical Sciences The University of Tokyo CREST, Japan Science and Technology Corporation (JST) 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 15, 3791–3792Publication Date (Web):April 2, 1999Publication History Received22 October 1998Published online2 April 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/ja983681vhttps://doi.org/10.1021/ja983681vrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views4315Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Hydrocarbons,Indoles,Organic reactions,Reagents Get e-Alerts
Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not (2023)

Visceral adiposity was associated with decreased time to IBD flare, but BMI was not. Future studies could test whether interventions that decrease visceral adiposity will improve IBD disease activity.
ChemInform Abstract: Copper‐Catalyzed Allylic Oxidation with Peresters (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alteration of Phenolic Composition in Lettuce (Lactuca sativa L.) by Reducing Nitrogen Supply Enhances its Anti-Proliferative Effects on Colorectal Cancer Cells (2019)

Consumption of vegetables rich in phenolic compounds has become a useful method to reduce the risk of developing several types of cancer. This study investigated the potential relationship between the alteration of phenolic compounds in lettuce induced by reduced nitrogen supply and its anti-proliferative effects on Caco-2 colorectal cancer cells. Our results showed that phenolic extracts from lettuce grown under low nitrogen conditions (LP) exhibited better anti-proliferative effects against Caco-2 cells, in part, by interfering with the cell cycle and inducing apoptosis, compared with those from lettuce supplied with adequate nitrogen. High performance liquid chromatography (HPLC) analysis and correlation analysis indicated that the better anticancer activity of LP may be not only related to the increased phenolic content, but also associated with the increased percentage contribution of quercetin to total phenolics. Taken together, alteration of phenolic composition by reduced nitrogen supply can be an effectively strategy for the development of healthy vegetables as anticancer products.
Q-switched mode-locking of an erbium-doped fiber laser incorporating a graphene oxide-deposited D-shaped fiber (2013)

We experimentally demonstrate a passively Q-switched, mode-locked fiber laser incorporating a graphene oxide (GO)-deposited side-polished D-shaped fiber. Using both features of nonlinear saturable absorption and large polarization dependence loss of the GO-deposited side-polished D-shaped fiber, stable Q-switched mode-locked pulses are readily obtained from an erbium fiber ring cavity.
Supplementary Table 1 from Targets of the Tumor Suppressor <i>miR-200</i> in Regulation of the Epithelial–Mesenchymal Transition in Cancer (2023)

&lt;p&gt;XLS file - 59K, Differentially regulated proteins for proteomic analysis comparing 344SQ/393P tumor lysates.&lt;/p&gt;
Characterization of the dominant midgap levels in Si-doped GaN by optical-isothermal capacitance transient spectroscopy (1997)

Optical-isothermal capacitance transient spectroscopy (O-ICTS) was used to characterize prominent midgap carrier traps in Si-doped n-type GaN grown by metalorganic vapor phase epitaxy. Strong carrier photoionization was observed from two deep levels to the conduction band. The first level photoionizes in the broad range from below 1.8 eV to over 2.3 eV. Seen in all n-type GaN, this level is believed to be defect related and involved in the commonly observed yellow luminescence. The second, more dominant O-ICTS peak develops with incident photon energy of ∼2.3 eV. This is a previously unreported, yet unidentified level of impurity nature. The two midgap states can be clearly distinguished by means of the time constant for photoionization of carriers from the deep levels.
In situ process diagnostics and modelling : symposium held April 6-7, 1999, San Francisco, California, U.S.A. (1999)

Fabrication of future generations of advanced film-based devices will require monitoring of ultrathin layers with sharp interfaces in which the layer thickness may reach atomic dimensions. It therefore becomes increasingly more important to be able to monitor film-deposition processes in situ and in real time under different background pressure conditions. Diffusion or surface segregation processes relevant to device fabrication also need to be characterized. To these ends, a variety of complimentary in situ, real-time characterization techniques are needed to advance the science and technology of thin films and interfaces. This book offers an interdisciplinary exchange of ideas from researchers with cross-disciplinary expertise. The application of in situ characterization methods are discussed in relation to different materials including oxides, nitrides, semiconductors, and metals analyzed at the macroscopic, microscopic and nanoscale level.
Modeling of time constituents for speech understanding (1993)

The analysis and interpretation of time constituents is important for most applications of speech understanding systems. Problems can be caused by the varying distribution of constituents. A basic set of time constituents were found in a corpus of domain specific (train schedule) utterances. A distributed representation of surface structure models and an incremental semantic analysis is used to manage the complexity. The knowledge base of the speech understanding system that provides the framework for the analysis and interpretation of time constituents uses the semantic network language ERNEST.
Oxidative Dehydrogenation of Ethanol over Au/TiO2 Photocatalysts (2012)

Abstract Au/TiO
Poor absorption of an un-theophylline xanthine bronchodilator (1980)

Journal Article Poor absorption of an un-theophylline xanthine bronchodilator Get access Leslie Hendeles, Pharm.D., Leslie Hendeles, Pharm.D. College of Pharmacy and Department of Pediatrics . The University of Iowa Iowa City, IA 52242 Search for other works by this author on: Oxford Academic Google Scholar Miles Weinberger, M.D Miles Weinberger, M.D College of Pharmacy and Department of Pediatrics . The University of Iowa Iowa City, IA 52242 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 37, Issue 2, 1 February 1980, Page 169, https://doi.org/10.1093/ajhp/37.2.169a Published: 01 February 1980