gebhart/patrepeval huggingface dataset:
A bidirectional telemetry method for long-term glucose monitoring using fast scan cyclic voltammetry (2006)

Introduction Glucose level can be monitored using fast scan cyclic voltammetry (FSCV) [1][2]. The FSCV is known to have better chemical resolution than conventional sensors. [2] The FSCV can be implemented wirelessly [3]. However, the latter system is based on Bluetooth unit which requires a battery in the internal unit. We propose a method for wireless transmission of FSCV where the internal unit has no battery thus is more suitable for continuous glucose monitoring.
Successful Treatment Using Coil Embolization of a Symptomatic Intrahepatic Portosystemic Venous Shunt Developing through a Patent Ductus Venosus in a Noncirrhotic Adult (2013)

The patient was a 60-year-old man with encephalopathy without liver cirrhosis. CT angiography revealed a patent ductus venosus between the anterior segmental branch of the portal vein and the middle hepatic vein. Coils were framed in the patent ductus venosus and then used to fill in the frame. After treatment, transarterial portography showed that the shunt flow of the ductus venosus had decreased significantly. After one day, the patient's disturbance of consciousness disappeared. Our case involved the adult-onset of a patent ductus venosus, which is extremely rare. This case is the first in which coil embolization was successfully achieved in a noncirrhotic elderly patient with a patent ductus venosus.
A Three-Component Enantioselective aza-Darzens Reaction (2017)

Key words aziridines - chiral phosphoric acid catalysis - diazoacetates - multicomponent reaction - aza-Darzens reaction
Differentiation of the Emerging Human Pathogens Trichosporon asahii and Trichosporon asteroides from Other Pathogenic Yeasts and Moulds by Using Species-Specific Monoclonal Antibodies (2014)

The fungal genus Trichosporon contains emerging opportunistic pathogens of humans, and is the third most commonly isolated non-candidal yeast from humans. Trichosporon asahii and T. asteroides are the most important species causing disseminated disease in immunocompromised patients, while inhalation of T. asahii spores is the most important cause of summer-type hypersensitivity pneumonitis in healthy individuals. Trichosporonosis is misdiagnosed as candidiasis or cryptococcosis due to a lack of awareness and the ambiguity of diagnostic tests for these pathogens. In this study, hybridoma technology was used to produce two murine monoclonal antibodies (MAbs), CA7 and TH1, for detection and differentiation of Trichosporon from other human pathogenic yeasts and moulds. The MAbs react with extracellular antigens from T. asahii and T. asteroides, but do not recognise other related Trichosporon spp., or unrelated pathogenic yeasts and moulds including Candida, Cryptococcus, Aspergillus, Fusarium, and Scedosporium spp., or the etiologic agents of mucormycosis. Immunofluorescence and Western blotting studies show that MAb CA7, an immunoglobulin G1 (IgG1), binds to a major 60 kDa glycoprotein antigen produced on the surface of hyphae, while TH1, an immunoglobulin M (IgM), binds to an antigen produced on the surface of conidia. The MAbs were used in combination with a standard mycological growth medium (Sabouraud Dextrose Agar) to develop an enzyme-linked immunosorbent assay (ELISA) for differentiation of T. asahii from Candida albicans and Cryptococcus neoformans in single and mixed species cultures. The MAbs represent a major advance in the identification of T. asahii and T. asteroides using standard mycological identification methods.
Histone Acetyltransferase CBP Is Vital To Demarcate Conventional and Innate CD8+ T-Cell Development (2009)

Defining the chromatin modifications and transcriptional mechanisms that direct the development of different T-cell lineages is a major challenge in immunology. The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with over 50 T-lymphocyte-essential transcriptional regulators. We show here that CBP, but not p300, modulates the thymic development of conventional adaptive T cells versus those having unconventional innate functions. Conditional inactivation of CBP in the thymus yielded CD8 single-positive (SP) thymocytes with an effector-, memory-, or innate-like T-cell phenotype. In this regard, CD8 SP thymocytes in CBP mutant mice were phenotypically similar to those reported for Itk and Rlk protein tyrosine kinase mutants, including the increased expression of the T-cell master regulatory transcription factor eomesodermin (Eomes) and the interleukin-2 and -15 receptor beta chain (CD122) and an enhanced ability to rapidly produce gamma interferon. CBP was required for the expression of the Itk-dependent genes Egr2, Egr3, and Il2, suggesting that CBP helps mediate Itk-responsive transcription. CBP therefore defines a nuclear component of the signaling pathways that demarcate the development of innate and adaptive naïve CD8(+) T cells in the thymus.
Canonical Matches of Human MicroRNAs with mRNAs: A Broad Matrix of Position and Size (2016)

Human mRNA matches across miR sequences constitute a positionally similar matrix of canonical hydrogen-bonding reactivity. This presents ample opportunities for contiguous binding independent of miR position. The ubiquitous 10 to 15-nt matches could serve as binding foci. Interaction of miRs with the abundant GC-rich 5'utr and cds counterparts could be important in the regulation of mRNA-ribosome interaction as well as in mRNA disposal. The lower density and GC content of a majority of 3'utr matches could mainly support a dynamic regulation by miRs.
G0800104 Consideration on Power Recovery from High Pressure Liquid Using a Hydraulic Motor (2015)

In recent years, the power conversion using oil pressure attracts attention as measures against global environment problems. Although a hydraulic motor is effective in oil pressure-power conversion, this is designed for high pressures such as several 10 MPa. So apparatus suitable for the oil pressure-power conversion of low-pressure is needed from now on. Authors made the property evaluation equipment for the power recovery which built into the closed circuit used a slanting axis type hydraulic pump/motor, and performed evaluation examination about the power recovery from the circulating oil of several MPa.
Cylindrical Transmission-Line Cloak for Microwave Frequencies (2008)

We present design and simulations of a cylindrical electromagnetic cloak which is based on a method employing periodic meshes of transmission-line networks. The cloaked object can be a connected or non-connected mesh of inclusions composed of an arbitrary material. In the example case studied in this work, we cloak a cylindrical mesh of rods made of a perfect electric conductor. Since the period of the cloaked object's inclusions is much smaller than the wavelength of the impinging radiation, the cloaked object is effectively impenetrable to the electromagnetic fields. When placed inside the proposed cloak, the total scattering cross section of the system is shown to be highly reduced in a large bandwidth, when compared to the case without the cloak.
Measurement of direct bilirubin by use of bilirubin oxidase. (1987)

We developed an enzymatic method for measuring direct-reacting bilirubin (DBIL) in serum. At pH 4.5, bilirubin oxidase (BOX) oxidizes mono-conjugated bilirubin, di-conjugated bilirubin, and most of the delta-bilirubin to biliverdin. The resulting decrease in absorbance at 460 nm is linearly related to the concentration of DBIL in serum. Mean DBIL values in the 51 patients' sera examined by the BOX method and a diazo procedure (Clin Chem 1982;28:2305) were 45.4 and 42.8 mg/L, respectively. For the same samples, mean values for DBIL and conjugated bilirubin by the Kodak "Ektachem" methods were 50.2 and 24.8 mg/L, respectively. Hemoglobin, up to 1.5 g/L, does not interfere. Unconjugated bilirubin reacts negligibly. Day-to-day CVs were 2.2% and 2.4% at DBIL concentrations of 37 and 74 mg/L, respectively.
Innovative Therapies Targeting the Virus and the Host for Treating Chronic Hepatitis B Virus Infection: From Bench to Bedside (2022)

Chronic hepatitis B (CHB) is a highly complicated pathological process in which the disease is initiated by the hepatitis B virus (HBV); however, host immune responses are primarily responsible for variable extents of liver damage. If the patients with CHB remain untreated, many CHB patients will eventually develop complications like cirrhosis of the liver (LC) and hepatocellular carcinoma (HCC). In 2019, an estimated 882,000 patients died due to HBV-related complications worldwide. Accordingly, several drugs with antiviral properties have been used to treat CHB patients during the last four decades. However, the treatment outcome is not satisfactory because viral suppression is not usually related to the containment of progressive liver damage. Although proper reconstruction of host immunity is essential in CHB patients, as of today, there is no acceptable immune therapeutic protocol for them. These realities have exposed new, novel, and innovative therapeutic regimens for the management of CHB patients. This review will update the scope and limitation of the different innovative antiviral and immune therapeutic approaches for restoring effective host immunity and containing the virus in CHB patients to block progression to LC and HCC.
Coulomb blockade in Sb nanocrystals formed in thin, thermally grown SiO2 layers by low-energy ion implantation (1998)

Sb nanocrystals were formed in thin, thermally grown SiO2 layers using low-energy ion implantation followed by thermal annealing. These Sb nanocrystals have good size and position uniformity. Both the narrow as-implanted profile and the compressive strain that exists near the SiO2/Si interface supposedly contribute to the uniformity. The I–V characteristics of the diode structure show a Coulomb blockade region around 0 V and a Coulomb staircase at 4.2 K. The Coulomb blockade region was observed up to a temperature of 100 K. The technique offers the possibility of developing practical Si-based single-electron devices.
Et3B-Induced Radical Addition of N,N-Dichlorosulfonamide to Alkenes and Pyrrolidine Formation via Radical Annulation (2003)

A highly regioselective radical addition of N,N-dichlorobenzenesulfonamide (dichloramine-B) to 1-alkenes is achieved at -78 degrees C by the use of triethylborane as a radical initiator. The reaction of 1,3-dienes with N,N-dichlorosulfonamide in the presence of Et(3)B regioselectively provides N-chloro-N-allylamide derivatives. N-chloro-N-allylamides thus obtained react with a variety of alkenes to furnish pyrrolidine derivatives in good yields. A radical annulation reaction among N,N-dichlorosulfonamide, 1,3-dienes, and alkenes has been developed.
STUDIES IN URETHANS I. MONO- AND DICARBETHOXY-GUANIDINES: DICARBETHOXY-ETHYL-ISO-UREA (1926)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTUDIES IN URETHANS I. MONO- AND DICARBETHOXY-GUANIDINES: DICARBETHOXY-ETHYL-ISO-UREAS. Basterfield and L. Evelyn PaynterCite this: J. Am. Chem. Soc. 1926, 48, 8, 2176–2179Publication Date (Print):August 1, 1926Publication History Published online1 May 2002Published inissue 1 August 1926https://pubs.acs.org/doi/10.1021/ja01419a026https://doi.org/10.1021/ja01419a026research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combining formal methods for the development of reactive systems (2011)

This paper deals with the use of two verification approaches: theorem proving and model checking. We focus on the Event–B method by using its associated theorem proving tool (Click_n_Prove), and on the language TLA+ by using its model checker TLC. By considering the limitation of the Event–B method to invariance properties, we propose to apply the language TLA+ to verify liveness properties on a software behaviour. We extend first the expressivity and the semantics of a B model (called temporal B model) to deal with the specification of fairness and eventuality properties. Second, we give transformation rules from a temporal B model into a TLA+ module. We present in particular, our prototype system called B2TLA+, that we have developed to support this transformation; then we can verify these properties thanks to the model checker TLC on finite state systems. For the verification of infinite–state systems, we propose the use of the predicate diagrams. We illustrate our approach on a case study of a parcel sorting system.
High Resolution Nuclear Magnetic Resonance Spectra of Methylsilicon Compounds (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh Resolution Nuclear Magnetic Resonance Spectra of Methylsilicon CompoundsHubert. SchmidbaurCite this: J. Am. Chem. Soc. 1963, 85, 15, 2336–2337Publication Date (Print):August 1, 1963Publication History Published online1 May 2002Published inissue 1 August 1963https://pubs.acs.org/doi/10.1021/ja00898a042https://doi.org/10.1021/ja00898a042research-articleACS PublicationsRequest reuse permissionsArticle Views604Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of automated vs manual analysis of corneal endothelial cell density and morphology in normal and corneal endothelial dystrophy‐affected dogs (2019)

The automated imaging software is unable to accurately identify cell borders in CED-affected dogs resulting in inaccurate estimates of ECD. Thus, manual analysis is recommended for use in clinical trials assessing adverse events associated with novel medical treatments and/or surgical procedures.
IONIC AND MIXED CONDUCTIONS IN Ag PHOTODOPING PROCESS (1990)

The recent progress in resolving the mechanism of the Ag photodoping phenomenon in chalcogenide glasses is reviewed. The study of the photodoping kinetics in Ag/As-S system under hydrostatic pressure to 100 kbar suggests that ionic and/or mixed conductions are responsible for the phenomenon.
Pluripotent Stem Cell‐Based Platforms in Cardiac Disease Modeling and Drug Testing (2017)

The ability to generate patient/disease-specific human pluripotent stem cell (hPSC)-derived cardiomyocytes (hPSC-CMs) brings a unique value to the fields of cardiac disease modeling, drug testing, drug discovery, and precision medicine. Further integration of emerging innovative technologies such as developmental-biology inspired differentiation into chamber-specific cardiomyocyte subtypes, genome-editing, tissue-engineering, and novel functional phenotyping methodologies should facilitate even more advanced investigations. Here, we review cornerstone concepts and recent highlights of hPSC-based cardiac disease modeling and drug testing.
LocaTag - An NFC-Based System Enhancing Instant Messaging Tools with Real-Time User Location (2010)

In recent years instant messaging tools have been successfully introduced to support communication and collaboration processes in work environments. Research suggests that the use of instant messaging tools lead to an increased feeling of connectedness, social presence and awareness within a collaborative group. Consequently, the goal of our research is to improve communication and collaboration within a group through automated and real-time dissemination of presence information, using instant messaging software. The paper describes LocaTag, a system that enhances instant messaging tools with real-time location information through the use of NFC enabled mobile devices. The LocaTag application is implemented as a prototype system that provides the Skype instant messaging application with automated status messages, reflecting the current location of a user. This location information is derived from a NFC-tag based check-in/-out routine incorporating the mobile phone of the user. The tie-in of NFC based location information and existing, broadly used instant messaging applications is an approach towards the real-timed is semination of presence information in collaborative groups. Its technical feasibility, limitations and future research approaches are discussed in this manuscript.
Identification of a Novel HIV-1 Second-Generation (CRF01_AE/B) Among Men Who Have Sex with Men in Tianjin, China (2019)

In this study, we report a novel HIV-1 second-generation recombinant form composed of CRF01_AE and subtype B detected from a married HIV-positive male subject infected through homosexual behavior in Tianjin in northern China. The near full-length genome analyses showed that two regions of subtype B inserted into the CRF01_AE backbone with four recombinant breakpoints observed in the <i>pol</i> gene region. Subregion tree analyses demonstrated that the CRF01_AE regions of the recombinant were greatly clustered with the CRF01_AE subcluster 4 lineage, which was found primarily among men who have sex with men (MSM) in northern China. To the best of our knowledge, this is the first detection of a novel HIV-1 second-generation recombinant form (CRF01AE/B) in Tianjin, which indicates active transmission networks of HIV-1 infection among MSM in this region. The emergence of the novel second-generation recombinant form highlights the increasing complexity of HIV-1 epidemic among MSM population and the importance to monitor potential novel circulating recombinant forms.
Resonant Effects on the Low-Frequency Vlasov Stability of Axisymmetric Field-Reversed Configurations (1978)

We investigate the effect of particle resonances on low-frequency magnetohydrodynamic modes in field-reversed geometries, e.g., an ion ring. It is shown that, for sufficiently high field reversal, modes which are hydromagnetically stable can be driven unstable by ion resonances. The stabilizing effect of a toroidal magnetic field is discussed.
Simulation of Coalescence and Breakup of Dispersed Water Droplets in Continuous Oil Phase (2018)

Petroleum industry uses shear devices such as chokes, valves, orifices and pumps, which cause droplet coalescence and breakup making the downstream separation process very challenging. Droplet-droplet coalescence leads to formation of larger droplets, which accelerate the phase separation, whereas the breakup of larger droplets into smaller ones delays the separation process. Computational Fluid Dynamic (CFD) simulations are conducted by ANSYS-Fluent software to track the droplet breakup and droplet-droplet coalescence, where the interfaces between the two phases are tracked by the Volume of Fluid (VOF) model. The material of droplet is water, while the continuous phase is oil. In this study, the effect of variables such as droplet diameter, droplet relative velocities as well as droplet motion directions on the time evolution of droplet-droplet coalescence and breakup is evaluated. The simulation results confirm that smaller droplet collisions lead to coalescence under wide ranges of droplet relative velocities, while larger droplet collisions result in droplet breakup at higher relative velocities. During coalescence, two droplets combine into one droplet, which deform in several times from one direction to orthogonal direction until recovering its shape or breakup. In addition, the simulation results show that fastest coalescence takes place when droplet collisions occur at optimum relative velocity, whereas droplet breakup occurs at higher velocities than the optimum velocity, and delay in coalescence happens at lower velocity. Furthermore, the simulation results clearly show that droplet moving direction play an important role in the occurrence of droplet coalescence and breakup. Comparison of the simulation results with the collected experimental data from literature confirm that the simulations are capable of predicting the evolution time of the droplet coalescence and breakup with high accuracy.
Review and comparison of inductive charging power electronic converter topologies for electric and plug-in hybrid electric vehicles (2013)

For the last two decades, significant improvements in charging technologies have been made. Moreover, novel applications have been proposed and tested, obtaining important and promising results. Inductive charging for electric vehicles (EV) and hybrid electric vehicles (HEV) is one of them. Because of the positive impact that this technology represents, it is important to understand the general characteristics of this novel application. This paper aims to give a general understanding of inductive charging systems for EV and HEV. The explanation of what is an inductive power transfer (IPT) transformer and how electrical power is transferred through air is presented. The review of the electrical characteristics of an IPT transformer is shown: derivation of equations and presentation of the equivalent circuit. The analysis and comparison of two different circuit topologies is also covered (series-series and parallel-parallel). Also, to validate the theoretical concepts, an IPT transformer setup with 5cm of air gap is simulated. The plots and circuit simulations where obtained in MATLAB and SIMULINK respectively.
Resonant Cooper-Pair Tunneling: Quantum Noise and Measurement Characteristics (2002)

We study the quantum charge noise and measurement properties of the double Cooper-pair resonance point in a superconducting single-electron transistor (SSET) coupled to a Josephson charge qubit. Using a density-matrix approach for the coupled system, we obtain a full description of the measurement backaction; for weak coupling, this is used to extract the quantum charge noise. Unlike the case of a nonsuperconducting SET, the backaction here can induce population inversion in the qubit. We find that the Cooper-pair resonance process allows for a much better measurement than a similar nonsuperconducting SET, and can approach the quantum limit of efficiency.