gebhart/patrepeval huggingface dataset:
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions (2007)

To define the specific role of the galanin receptors when mediating the effect of galanin, effective tools for distinct activation and inhibition of the different receptor subtypes are required. Several of the physiological effects modulated by galanin are implicated to be mediated via the GalR2 subtype and have been distinguished from GalR1 effects by utilizing the Gal(2-11) peptide, recognizing only GalR2 and GalR3. In this study, we have performed a mutagenesis approach on the GalR2 subtype and present, for the first time, a molecular characterization of the interactions responsible for ligand binding and receptor activation at this receptor subtype. Our results identify four residues, His(252) and His(253) located in transmembrane domain 6 and Phe(264) and Tyr(271) in the extracellular loop 3, to be of great significance. We show evidence for the N-terminal tail of GalR2 to participate in ligand binding and that selective binding of Gal(2-11) includes interaction with the Ile(256) residue, located at the very top of TM 6. In conclusion, we present a mutagenesis study on GalR2 and confer interactions responsible for ligand binding and receptor activation as well as selective recognition of the Gal(2-11) peptide at this receptor subtype. The presented observations could be of major importance for the design and development of new and improved peptide and non-peptide ligands, selectively activating the GalR2 subtype.
Nanocrystalline ZnON; High mobility and low band gap semiconductor material for high performance switch transistor and image sensor application (2014)

Interest in oxide semiconductors stems from benefits, primarily their ease of process, relatively high mobility (0.3-10 cm(2)/vs), and wide-bandgap. However, for practical future electronic devices, the channel mobility should be further increased over 50 cm(2)/vs and wide-bandgap is not suitable for photo/image sensor applications. The incorporation of nitrogen into ZnO semiconductor can be tailored to increase channel mobility, enhance the optical absorption for whole visible light and form uniform micro-structure, satisfying the desirable attributes essential for high performance transistor and visible light photo-sensors on large area platform. Here, we present electronic, optical and microstructural properties of ZnON, a composite of Zn3N2 and ZnO. Well-optimized ZnON material presents high mobility exceeding 100 cm(2) V(-1) s(-1), the band-gap of 1.3 eV and nanocrystalline structure with multiphase. We found that mobility, microstructure, electronic structure, band-gap and trap properties of ZnON are varied with nitrogen concentration in ZnO. Accordingly, the performance of ZnON-based device can be adjustable to meet the requisite of both switch device and image-sensor potentials. These results demonstrate how device and material attributes of ZnON can be optimized for new device strategies in display technology and we expect the ZnON will be applicable to a wide range of imaging/display devices.
ChemInform Abstract: ISOLATION AND CHARACTERIZATION OF (PNP)2CO(CN)4, AN UNUSUAL SQUARE‐PLANAR TETRACYANOCOBALT(II) COMPLEX (1984)

Abstract Wasserfreies CoClg reagiert mit 4 Äquivalenten Bis‐[triphenylphosphinl‐iminiumcyanid (PNP)CN in DMF zur monomeren Titelverbindung, der ersten low‐spin, quadratisch‐plana?ren Co(II)‐Verbindung mit nur einem einzi‐ 156 gen Typ von einzähnigem Liganden.
A review of the US Grade A raw milk supply, its quality, marketing and pricing (1998)

As with any business, profitability is essential for the successful operation of a dairy farm. Profitability depends on the production performance of the dairy herd and a favourable price for the milk produced. While the Grade A regulations set the minimum quality standards and provide for monitoring and enforcement, the federal order system insures the producer a fair market price. Through the integration of performance standards and marketing, the United States has benefited from an abundant supply of safe and wholesome milk. However, the marketing and pricing of the US raw milk supply is beginning to model itself after the UK Milk Board concept because of mergers of cooperatives 1 3 into ever larger units, increase in size of production units at the farm level and regulation of the surplus Grade A raw milk supply .
Die Wirkung von grünem Tee und Matchatee, sowie ihrer Bestandteile Epigallocatechingallat und Quercetin auf MCF-7- und MDA-MB-231-Mammakarzinomzellen (2018)

In dieser Studie wurde das antikazinogene Potential von grünem Tee, seinen Bestandteilen Epigallocatechingallat und Quercetin, sowie des Tamoxifens auf estrogenrezeptor-negative (MDA-MB-231) und -positive (MCF-7) Mammakarzinomzellen untersucht.
GFDM Frame Design for 5G Application Scenarios (2017)

The services foreseen for 5G networks will demand a vast number of challenging requirements to be fulfilled by the physical layer. These services can be grouped into application scenarios, each one with a key requirement to be addressed by the 5G network. A flexible waveform associated with a appropriate data frame is an essential feature in order to guarantee the support of contrasting requirements from different application scenarios such as Enhanced Mobile Broadband, Internet of Things, Tactile Internet and Internet Access for Remote Areas. In this paper, we propose a flexible data frame based on Generalized Frequency Division Multiplexing(GFDM) that can be tailored to address the specific key requirements of the different 5G scenarios. The paper also presents the physical layer parametrization that can be used for each application.
Automatic detection of lameness in gestating group-housed sows using positioning and acceleration measurements (2016)

Lameness is an important issue in group-housed sows. Automatic detection systems are a beneficial diagnostic tool to support management. The aim of the present study was to evaluate data of a positioning system including acceleration measurements to detect lameness in group-housed sows. Data were acquired at the Futterkamp research farm from May 2012 until April 2013. In the gestation unit, 212 group-housed sows were equipped with an ear sensor to sample position and acceleration per sow and second. Three activity indices were calculated per sow and day: path length walked by a sow during the day (Path), number of squares (25×25 cm) visited during the day (Square) and variance of the acceleration measurement during the day (Acc). In addition, data on lameness treatments of the sows and a weekly lameness score were used as reference systems. To determine the influence of a lameness event, all indices were analysed in a linear random regression model. Test day, parity class and day before treatment had a significant influence on all activity indices (P<0.05). In healthy sows, indices Path and Square increased with increasing parity, whereas variance slightly decreased. The indices Path and Square showed a decreasing trend in a 14-day period before a lameness treatment and to a smaller extent before a lameness score of 2 (severe lameness). For the index acceleration, there was no obvious difference between the lame and non-lame periods. In conclusion, positioning and acceleration measurements with ear sensors can be used to describe the activity pattern of sows. However, improvements in sampling rate and analysis techniques should be made for a practical application as an automatic lameness detection system.
TXOP sharing with Coordinated Spatial Reuse in Multi-AP Cooperative IEEE 802.11be WLANs (2022)

IEEE 802.11be networks (aka Wi-Fi 7) will have to cope with new bandwidth-hungry and low-latency services such as eXtended Reality and multi-party cloud gaming. With this goal in mind, transmit opportunity (TXOP) sharing between coordinated access points (APs) may contribute to alleviating inter-AP contention, hence increasing the overall network throughput. This paper evaluates two coordinated TXOP sharing strategies: coordinated time division multiple access (c-TDMA) and coordinated-TDMA with spatial reuse (c-TDMA/SR). We show that, while c-TDMA alone does not result in any significant improvement in terms of the WLAN throughput, it lays the groundwork to implement coordinated SR (c-SR) techniques. To evaluate the performance of c-TDMA/SR, we propose a fair scheduler able to select the best subset of parallel transmissions in WLAN deployments, as well as the appropriate power levels to be used by APs and stations (STAs), leading to maximum performance. The results obtained for c-TDMA/SR show significant throughput gains compared with c-TDMA, with values higher than 140% in 90% of the considered scenarios.
Oncoprecipitins: A novel type of natural substances and oncofetal antigens (1993)

Abstract
Retinoschisin, a Photoreceptor-Secreted Protein, and Its Interaction with Bipolar and Müller Cells (2003)

Usually, photoreceptors interact with other retinal cells through the neurotransmitter glutamate. Here we describe a nonsynaptic interaction via a secreted protein, retinoschisin. Using in situ hybridization, we found that from early postnatal life retinoschisin mRNA is present only in the outer retina of the mouse, and with single-cell RT-PCR we demonstrated its localization in rod and cone photoreceptor cells but not in Müller cells. Western blot analyses of proteins from cultured ocular tissues and microdissected outer and inner retinas, as well as from the culture media of these samples, showed that retinoschisin is secreted from the photoreceptor cells. Immunostaining of permeabilized and nonpermeabilized dissociated retinal cells revealed that retinoschisin is mainly inside and outside the photoreceptors, outside bipolar cells, and associated with plasma membranes of Müller cells and inside their distal processes. Because we showed previously that retinoschisin is distributed all over the retina, our current data suggest that after synthesis and secretion by the photoreceptors, retinoschisin reaches the surface of retinal cells and mediates interactions/adhesion between photoreceptor, bipolar, and Müller cells, contributing to the maintenance of the cytoarchitectural integrity of the retina. These interactions may not occur when the gene encoding retinoschisin is mutated, as it occurs in X-linked juvenile retinoschisis, a disease that results in morphological and electrophysiological defects of the retina.
A convenient synthetic route towards H-bisphosphinates (2018)

A practical generalisable procedure to synthesize hydroxymethylene H-bisphosphinates has been optimised. Unlike previous reports, numerous alkyl (including an alendronate bisphosphinate analogue) or (hetero)aryl compounds were rapidly obtained in satisfactory to excellent yields. A side product could have been identified as a phosphino-phosphonate isomer and plausible mechanistic pathways are proposed here. Moreover to check the literature data, a pKa value study was also performed.
δ- and γ-Tocopherols, but not α-Tocopherol, Inhibit Colon Carcinogenesis in Azoxymethane-Treated F344 Rats (2012)

The cancer preventive activity of vitamin E has been extensively discussed, but the activities of specific forms of tocopherols have not received sufficient attention. Herein, we compared the activities of δ-tocopherol (δ-T), γ-T, and α-T in a colon carcinogenesis model. Male F344 rats, seven weeks old, were given two weekly subcutaneous injections of azoxymethane (AOM) each at a dose of 15 mg/kg body weight. Starting 1 week before the AOM injection, the animals were maintained on a modified AIN76A diet, or the same diet containing 0.2% of δ-T, γ-T, α-T, or a γ-T-rich mixture of tocopherols (γ-TmT), until the termination of the experiment at 8 weeks after the second AOM injection. δ-T treatment showed the strongest inhibitory effect, decreasing the numbers of aberrant crypt foci by 62%. γ-T and γ-TmT were also effective, but α-T was not. Immunohistochemical analysis showed that δ-T and γ-T treatments reduced the levels of 4-hydroxynonenal and nitrotyrosine and the expression of cyclin D1 in the colon, preserved the expression of PPAR-γ, and decreased the serum levels of prostaglandin E2 and 8-isoprostane. Supplementation with 0.2% δ-T, γ-T, or α-T increased the respective levels of tocopherols and their side-chain degradation metabolites in the serum and colon tissues. Rather high concentrations of δ-T and γ-T and their metabolites were found in colon tissues. Our study provides the first evidence for the much higher cancer preventive activity of δ-T and γ-T than α-T in a chemically induced colon carcinogenesis model. It further suggests that δ-T is more effective than γ-T.
Modelling of electrical history effect on polymer conductivity (2020)

Jicable HVDC'13 132 ZREE N°5/2019 JICABLE'19 Modelling of electrical history effect on polymer conductivity Raphael Guffond Anthony Combessis Nexans, (France) Stephane Hole Laboratoire de Physique et d’Etude des Materiaux, ESPCI-ParisTech, (France) Introduction The insulation system of extruded High Voltage Direct Current (HVDC) Power Cables, composed of insulation layer between two semiconductive layers, reveals phy- sical and chemical heterogeneities at several scales. Insulation generally consists of crosslinked ethylene homopolymer, the standard being low density crosslinked poly- ethylene (XLPE). As a semi-crystalline polymer, XLPE presents a heterogeneous mor- phological structure. Moreover, its formulation with other polymers, fillers or adjuvants and its chemical crosslinking, achieved in catenary vulcanization lines, also induces chemical heterogeneities [1]. This heterogeneous microstructure, which is evolving over time, strongly impacts the electrical properties of insulation system and its durabi- lity. Some models were developed to consider these heterogeneities in the simulation of insulation electrical properties [2]. However, these models are generally base
Array configurations for higher power generation in piezoelectric energy harvesting (2009)

Electric power generation efficiencies using a vibration of a piezoelectric element with array configurations were discussed. We have been investigating the piezoelectric energy harvesting using a polyurea thin film, which can be fabricated on the micro array structure. In our previous work, it was predicted that the higher power generation efficiency could be obtained with the shorter cantilever configuration. To realize the piezoelectric energy harvesting device with the larger volume energy density, the energy conversion efficiencies of the different array configurations were investigated. The energy conversion efficiencies and the volume energy densities of the energy harvesting element with several array configurations were calculated through the finite element analysis (FEA). Two energy harvesting devices with the different array configurations were designed. In the same volume of 22 × 19 × 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , the large array configuration has two long cantilevers (18 × 9.5 × 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) and the small one has eight short cantilevers (9 × 4.25 × 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ). The 1-mm-thick piezoelectric zirconate titanate (PZT) elements were attached on the surface of each aluminum cantilever. The harmonic vibration in the vertical direction at the fundamental resonance frequencies of the cantilevers was applied by using a vibration generator, and the electric power generation was measured by connecting the load resistance. The larger volume energy density as an electric power generator could be obtained with the shorter array configuration. The larger output power was generated with the larger applying vibration. The relationship between the load resistance and the output power was investigated. The maximum output power of 2.8 mW and the conversion efficiency of 8.07% were achieved with the vibration velocity of 0.7 mm/s and the load resistance of 51 k¿.
Pulsed amperometric detection of glucose in biological fluids at a surface-modified gold electrode (1989)

A nonenzymatic glucose sensor that utilizes permselective membranes to achieve the selectivity required for screening glucose in biological fluids has been described. Interference from endogenous oxidizable substances such as amino acids, urea, ascorbic acid, and uric acid, as well as the effect of chloride and proteins on glucose response, is studied by using flow injection analysis. A set of membranes made of Naflin perfluorinated membrane and collagen, when arranged in front of the working electrode (gold), result in significant improvement in the system selectivity. Even at physiological pH, which is far from being the optimum pH for pulsed amperometric detection of carbohydrates, the sensor shows a good limit of detection (4-5 micrograms of glucose injected).
High-speed, low chirp, directly modulated 1.55-/spl mu/m DFB laser sources for 10 Gbit/s local distribution (1996)

Summary form only given. In this paper we describe 1.55-/spl mu/m DFB lasers for communications applications using p-doped compressively strained multiple quantum well (MQW) active regions to provide devices with extremely high modulation bandwidths and low wavelength chirp.
Potential therapeutic applications of fructose-1,6-diphosphate (1998)

Ischaemia-related tissue injury is the leading cause of death in developed countries. Drugs that can reduce ischaemic injury would be beneficial in treatment of myocardial infarction (MI), surgical trauma and stroke. Fructose-1,6-diphosphate (FDP) is a key intermediate in anaerobic glycolysis and is the product of the major regulatory enzyme in the pathway (phosphofructokinase). Preclinical and clinical data suggest that FDP has substantial cytoprotective effects in a variety of ischaemia-reperfusion injury scenarios. Evidence indicates that FDP has a direct effect on ATP pools, reduces ischaemia-induced tissue damage and has positive inotropic effects on heart function. The clinical data suggest that FDP may be a useful drug in a variety of ischaemic and inflammatory clinical settings where acute management of tissue injury is desired. Potential uses include: iv. administration for the reduction of ischaemic injury in sickle cell anaemia, bypass surgery, congestive heart failure, myocardial infarction, as well as organ preservation in transplants.
Cloud and radiation mission with active and passive sensing from the space station (1999)

A cloud and aerosol radiative forcing and physical process study involving active laser and radar profiling with a combination of passive radiometric sounders and imagers would use the space station as an observation platform. The objectives are to observe the full three dimensional cloud and aerosol structure and the associated physical parameters leading to a complete measurement of radiation forcing processes. The instruments would include specialized radar and lidar for cloud and aerosol profiling, visible, infrared and microwave imaging radiometers with comprehensive channels for cloud and aerosol observation and specialized sounders. The low altitude, available power and servicing capability of the space station are significant advantages for the active sensors and multiple passive instruments.
Integrated GlycoProteome Analyzer (I-GPA) for Automated Identification and Quantitation of Site-Specific N-Glycosylation (2016)

Human glycoproteins exhibit enormous heterogeneity at each N-glycosite, but few studies have attempted to globally characterize the site-specific structural features. We have developed Integrated GlycoProteome Analyzer (I-GPA) including mapping system for complex N-glycoproteomes, which combines methods for tandem mass spectrometry with a database search and algorithmic suite. Using an N-glycopeptide database that we constructed, we created novel scoring algorithms with decoy glycopeptides, where 95 N-glycopeptides from standard α1-acid glycoprotein were identified with 0% false positives, giving the same results as manual validation. Additionally automated label-free quantitation method was first developed that utilizes the combined intensity of top three isotope peaks at three highest MS spectral points. The efficiency of I-GPA was demonstrated by automatically identifying 619 site-specific N-glycopeptides with FDR ≤ 1%, and simultaneously quantifying 598 N-glycopeptides, from human plasma samples that are known to contain highly glycosylated proteins. Thus, I-GPA platform could make a major breakthrough in high-throughput mapping of complex N-glycoproteomes, which can be applied to biomarker discovery and ongoing global human proteome project.
On the Accurate Performance Evaluation of the LTE-A Random Access Procedure and the Access Class Barring Scheme (2017)

The performance evaluation of the random access (RA) in LTE-A has recently become a major research topic as these networks are expected to play a major role in future 5G networks. Up to now, the key performance indicators (KPIs) of the RA in LTE-A have been obtained either by performing a large number of simulations or by means of analytic models that, oftentimes, sacrifice precision in exchange for simplicity. In this paper, we present an analytical model for the performance evaluation of the LTE-A RA procedure that incorporates the access class barring (ACB) scheme. By means of this model, each and every one of the KPIs suggested by the 3GPP can be obtained with minimal error when compared with results obtained by simulation. To the best of our knowledge, this paper presents the most accurate analytical model, which can be easily adapted to incorporate modifications of network parameters and/or extensions to the LTE-A system. In addition, our model of the ACB scheme can be easily incorporated to other analytic models of similar nature without further modifications.
Hydrogen Generation by Photoelectrochemical Splitting of Water by Using CdS/TiO<sub>2</sub> Nanotube Photoanode (2011)

In this study, hydrogen is generated from water via photoelectrochemical (PEC) process by using CdS/TiO2 photoanode, which is obtained in sequence chemical bath deposition (s-CBD) process. Experimentally, the CdS was deposited on TiO2 NTAs in s-CBD process. First, the TiO2 NTAs is immersed in Cd(NO3)2 and Na2S solution subsequently several cycles followed by annealing to get CdS/TiO2 photoanode. In this work, the factors were studied including immersion cycle, annealing temperature and UV illumination. The surface morphology, crystalline structure and CdS amount were characterized by SEM and XRD. The photoactivities of CdS/TiO2 photoanodes and hydrogen generation rate were investigated by PEC splitting of water. The results showed that the photoanode annealing in air at 300 °C had the highest photoactivity and the crystalline structure of CdS was composed of zinc blende and a small amount of wurtzite. The saturated current density was 6.163 mA/cm2 and the maximum photoelectrochemical conversion was 4.45 % under Xenon lamp (I0 = 100 mW/cm2) illumination. Besides, the photoactivity of CdS(UV)/TiO2 prepared under UV (λmax=253.7 nm) illumination was reduced. This was probably due to the aggregation of CdS. To sum up, the CdS/TiO2 photoanodes for photoelectrochemical splitting water could be a high prospective process of the energy source.