gebhart/patrepeval huggingface dataset:
Evaluation of Effects of Chinese Prescription Kangen-karyu on Diabetes-Induced Alterations such as Oxidative Stress and Apoptosis in the Liver of Type 2 Diabeticdb/dbMice (2012)

The present study was conducted to examine whether Kangen-karyu has an ameliorative effect on diabetes-induced alterations such as oxidative stress and apoptosis in the liver of type 2 diabetic db/db mice. Kangen-karyu (100 or 200 mg/kg body weight/day, p.o.) was administered every day for 18 weeks to db/db mice and its effect was compared with vehicle-treated db/db and m/m mice. The administration of Kangen-karyu decreased the elevated serum glucose and leptin concentrations in db/db mice, and reduced the increased oxidative biomarkers including the generation of reactive oxygen species and lipid peroxidation in the liver. The db/db mice exhibited the upregulation of nicotinamide adenine dinucleotide phosphate oxidase subunits, NF-E2-related factor 2, heme oxygenase-1, nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase levels in the liver; however, Kangen-karyu treatment significantly reduced those expressions. Moreover, the augmented expressions of apoptosis-related proteins, Bax, cytochrome c, c-Jun N-terminal kinase (JNK), phosphor-JNK, AP-1, and caspase-3, were downregulated by Kangen-karyu administration. Hematoxylin-eosin staining showed that the increased hepatocellular damage in the liver of db/db mice improved by Kangen-karyu administration. Our findings support the therapeutic evidence for Kangen-karyu ameliorating the development of diabetic hepatic complications via regulating oxidative stress and apoptosis.
Reactions and diastereoselectivity of N2-arylsulfonyl amidine anions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions and diastereoselectivity of N2-arylsulfonyl amidine anionsPhilip Magnus and John MoursounidisCite this: J. Org. Chem. 1991, 56, 4, 1529–1534Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00004a035https://doi.org/10.1021/jo00004a035research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effects of Interleukin-1 and Interleukin-1 Receptor Antagonist in AIDS-Kaposiʼs Sarcoma (1995)

Kaposi's sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS directly through viral protein(s) or indirectly through regulation of cytokines such as IL-1 and IL-6. We have shown that AIDS-KS spindle cells express IL-1 beta and that IL-1ra inhibits KS-spindle cell growth. IL-1ra had little effect on human umbilical vein endothelial cells (HUVEC), human aortic smooth muscle cells (HASM), and human foreskin fibroblast (NN41). These findings support an autocrine activity for IL-1. Furthermore, exogenous IL-1 can enhance AIDS-KS cell growth, and this effect is completely blocked by IL-1ra. As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF, both of which are autocrine growth factors for KS. IL-1ra is thus a potential candidate for the treatment of AIDS-associated KS.
The thermodynamic ladder in geomicrobiology (2011)

A tenet of geomicrobiology is that anaerobic life in the subsurface arranges itself into zones, according to a thermodynamic ladder. Iron reducers, given access to ferric minerals, use their energetic advantage to preclude sulfate reduction. Sulfate reducers exclude methanogens in the same way, by this tenet, wherever the environment provides sulfate. Examining usable energy---the energy in excess of a cell9s internal stores---in subsurface environments, we find that in groundwater of near neutral pH the three functional groups see roughly equivalent amounts. Iron reducers hold a clear energetic advantage under acidic conditions, but may be unable to grow in alkaline environments. The calculations fail to identify a fixed thermodynamic hierarchy among the groups. In long-term bioreactor experiments, usable energy did not govern microbial activity. Iron reducers and sulfate reducers, instead of competing for energy, entered into a tightly balanced mutualistic relationship. Results of the study show thermodynamics does not invariably favor iron reducers relative to sulfate reducers, which in turn do not necessarily have an energetic advantage over methanogens. The distribution of microbial life in the subsurface is controlled by ecologic and physiologic factors, and cannot be understood in terms of thermodynamics alone.
Cathodic Reduction of Isatin-3-oxime (1993)

The molecule of isatin-3-oxime was studied polarografically over the region of pH 1 to 13. Cathodic reduction within the region of pH 1 to 10.5 gives rise to a single four-electron polarographic wave due to the reduction of the oxime group, whereas two polarographic waves are observed at pH 10.5 to 13: one is due to the reduction of the isatin-3-oxime anion, the other, more negative wave is associated with the reduction of the oxime group in the α-oxime isatinic acid anion, which is the product of hydrolytic cleavage of the isatin ring in the basic pH region. The experimental results give evidence that the substance can exist as seven ionic and molecular species in dependence on pH. The species have been confirmed polarographically, by IR and electronic spectroscopy, potentiometrically and by paper electrophoresis.
Electroacoustic characterisation of +64 degrees and +41 degrees Y-rotated LiNbO/sub 3/ for wide bandwidth low loss filter design (2002)

Acoustic propagation on metallized surface high-coupling-coefficient 64 degrees and 41 degrees rotated Y-cut LiNbO/sub 3/ was investigated experimentally and theoretically. A complete set of experimentally determined acoustic parameters in the 0.85-tp-1.6-GHz frequency range is presented. 11.6% and 21% coupling constant values have been deduced from transducer admittance measurement for 64 degrees and 41 degrees LiNbO/sub 3/ respectively. These data have been applied to the design of 1-GHz image impedance connected low-loss filters. 7% and 10% 3-dB fractional bandwidth was obtained with 8- and 13-dB insertion loss on 64 degrees and 41 degrees LiNbO/sub 3/, respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
La réception du culte de Mithra en Italie et dans les provinces occidentales de l’Empire romain (Ier – IVe siècle) (2016)

Le culte de Mithra a acheve de s’installer dans l’Empire romain au IIIe siecle. Il a prospere dans une periode de mutation des pratiques religieuses. En dispensant par initiation un acces a ses rites, en appliquant des epreuves theâtralisees de progression, en imposant le secret et en provoquant une experience relationnelle avec son dieu, sa proposition religieuse s’inscrivait dans la phenomenologie des mysteres antiques. Mithra a ete recu en territoire romain et dans les provinces occidentales de l’Empire par des hommes d’horizons geographiques et ethniques varies, mais reunis par des caracteres communs quant a leur niveau social et culturel. Les mobiles qui les ont attire ont pu etre l’attrait d’un reseau communautaire, la recherche d’une valorisation existentielle dans ce reseau interactif, l’acces a une initiation spirituelle dans un contexte culturel avance ou peut-etre la curiosite. Les expressions initiatiques transcrites par les mithraea symbolisent la liberation de l’individu dans le monde, sans proner de remise en question de la structure sociale. Meme s’il est demeure au rang des cultes prives ou etrangers dans le systeme imperial, avec un dieu d’origine orientale, mais plutot mis en scene sous une forme orientalisee, avec une structure mysterique grecque et une ethique stoicienne, il resulte de cette recherche qu’on doit considerer le culte de Mithra en Occident sous l’angle receptif d’un culte romain, mais avec deja, dans cette epoque de transformation une forte propension a l’universalite.
Arthroscopic anterior instability repair (2017)

Traumatic anterior instability of the shoulder is described as an anterior–inferior capsulo-labral disruption associated with anterior shoulder dislocation.1 It characteristically occurs in young individuals during sports, with an estimated incidence of 11.2 cases per 100,000 persons annually.2–8 It is the most frequent type of joint dislocation and a significant cause of disability, leading to time lost from sports and work.9 Recurrence of anterior shoulder dislocation following an initial injury is strongly associated with age at the time of dislocation, with recurrence rates ranging anywhere from 60% to 100%.5,10–13 Younger patients, ages less than 20 years, have a recurrence rate as high as 86.7%, which declines with age.5,6,8
Primary and coupled motions in the intact and the ACL‐deficient knee: An in vitro study in the goat model (1992)

Quadrupeds are commonly used as animal models to study healing of anterior cruciate ligament (ACL) reconstructions. While rabbits, dogs, goats, and sheep have been used, goats and sheep are increasingly being employed because of the larger joint size that facilitates surgery, ease of availability, and lower expense to maintain in the farm environment. In spite of this, little is known about the function of the ACL in controlling primary and coupled motions in the quadruped. We report here on the measurements of these motions in goats, with the application of anterior-posterior forces, varus-valgus moments, and internal-external moments in the intact and ACL-deficient knee. Sectioning the ACL caused significant increases in primary anterior translation, and in varus-valgus and internal rotations. The increases in anterior translation were similar in amount and dependence on flexion angle to those seen in human knees. The increase in varus averaged 7 degrees and did not depend on flexion angle, whereas the increase in valgus was significant only in the flexed knee. The increases in internal tibial rotation were greatest in extension, whereas the increases in external rotation were small and independent of flexion angle. When the ACL was cut, coupled internal rotation increased with an anterior force as well as a valgus moment. Large increases were seen in coupled anterior translation with the application of varus and valgus moments, whereas smaller increases were seen with internal and external moments. These findings demonstrate that the ACL restrains multiple motions in the goat knee. This study also provides baseline data for future studies of ACL reconstruction.
Acute Kidney Injury After Cardiac Surgery (2009)

AKI after cardiac surgery is highly prevalent and prognostically important. Therapies aimed at mitigating preoperative anemia, perioperative red blood cell transfusions, and surgical reexploration may offer protection against this complication.
Gas Injection as a Method for Improved Recovery in Gas-Condensate Reservoirs with Active Support (2000)

Abstract One of the greatest problems currently in the oil industry is the difficulty for reaching a high hydrocarbon recovery in gas-condensate fields, the main problem being the pressure and the presence of active aquifer in such reservoirs. When a reservoir lacks active aquifer their recovery are very low of the order of 20 to 30 % for condensates and between 70 to 80 % for the gas. In reservoirs with active aquifers, their recovery factors are greater, of the order of 50% in condensates and about 70% for gas; however, a severe water invasion exists in the productive areas leaving about 40% of trapped hydrocarbons. The present paper describes a technical study for the implementation of recovery methods improved with gases, and the different factors of hydrocarbon recovery factors obtained using different gases such as dry gas, CO2, nitrogen, flue-gas and other feasible combinations of injection gases The best method obtained in such study consists on the injection of a dry gas in the zone of interest very near the water front, in order to avoid the entry of the water to the well and to recede the level of the current water in the perforations with high water cut, thus recovering trapped hydrocarbons, therefore obtaining high recovery factors of the order of 70 to 90 % of the original volume.
Time-spread multiple-access (TSMA) protocols for multihop mobile radio networks (1997)

This paper introduces a novel technique called protocol threading, yielding a deterministic protocol that gives a guaranteed upper bound on the transmission delay of each packet at every node in a multihop mobile network. By eliminating the maximum degree constraint, the new method improves upon existing time-spread multiple-access (TSMA)-type protocols while preserving the advantages of the deterministic operation and topology transparency. We introduce the protocol threading solution, derive the maximum delay bound in a mobile topology, and analyze the performance of the protocol.
Darstellung und Kristallstruktur von Barium‐Cadmium‐Thiostannat (iv) BaCdSnS4 (1980)

Abstract BaCdSnS 4 wurde erstmals präpariert und die Kristallstruktur an Einkristallen bestimmt. Gitterkonstanten: a = 2186 ± 2; b = 2169 ± 1; c = 1318 ± 0,5 pm. Raumgruppe C ‐Fdd2. Die Kristallstruktur enthält Doppeltetraeder [CdSnS 4 ] 2− . Sie sind in charakteristischer Weise zu zweidimensionalen, unendlichen Netzen verknüpft. Der Aufbau der Kristallstruktur wird beschrieben und diskutiert.
Calculation of the hard sphere radial distribution function (1992)

We describe a recursive formula for calculating the hard sphere radial distribution function under the Percus-Yevick approximation. It provides a simple and exact way to evaluate the expressions arising in Wertheim's solution of the hard sphere radial distribution function. The method does not increase in complexity at large distances. It has been used to evaluate the function at distances up to 20 times the hard sphere diameter. The same recursive formula can be applied to calculate derivatives of the distribution function which are useful in the thermodynamic analysis of equations of state obtained from perturbation theories.
Development andin VitroCharacterization of a Novel Bifunctional μ-Agonist/δ-Antagonist Opioid Tetrapeptide (2011)

The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that co-administration of a μ-opioid receptor (MOR) agonist and δ-opioid receptor (DOR) antagonist can decrease MOR agonist-induced tolerance and dependence development after chronic exposure. Clinically, a single ligand displaying multiple efficacies (e.g., MOR agonism concurrently with DOR antagonism) would be of increased value over two drugs administered simultaneously. Guided by modeling of receptor-ligand complexes we have developed a series of potent non-selective opioid tetrapeptides that have differing efficacy at MOR and DOR. In particular, our lead peptide (KSK-103) binds with equal affinity to MOR and DOR but acts as a MOR agonist with similar efficacy but greater potency than morphine and a DOR antagonist in cellular assays measuring both G protein stimulation and adenylyl cyclase inhibition.
Data from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms (2023)

&lt;div&gt;Abstract&lt;p&gt;Constitutive activation of NF-κB is a hallmark of the activated B cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), owing to upstream signals from the B-cell receptor (BCR) and MYD88 pathways. The linear polyubiquitin chain assembly complex (LUBAC) attaches linear polyubiquitin chains to IκB kinase-γ, a necessary event in some pathways that engage NF-κB. Two germline polymorphisms affecting the LUBAC subunit RNF31 are rare among healthy individuals (∼1%) but enriched in ABC DLBCL (7.8%). These polymorphisms alter RNF31 α-helices that mediate binding to the LUBAC subunit RBCK1, thereby increasing RNF31–RBCK1 association, LUBAC enzymatic activity, and NF-κB engagement. In the BCR pathway, LUBAC associates with the CARD11–MALT1–BCL10 adapter complex and is required for ABC DLBCL viability. A stapled RNF31 α-helical peptide based on the ABC DLBCL–associated Q622L polymorphism inhibited RNF31–RBCK1 binding, decreased NF-κB activation, and killed ABC DLBCL cells, credentialing this protein–protein interface as a therapeutic target.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; We provide genetic, biochemical, and functional evidence that the LUBAC ubiquitin ligase is a therapeutic target in ABC DLBCL, the DLBCL subtype that is most refractory to current therapy. More generally, our findings highlight the role of rare germline-encoded protein variants in cancer pathogenesis. &lt;i&gt;Cancer Discov; 4(4); 480–93. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;See related commentary by Grumati and Dikic, p. 394&lt;/p&gt;&lt;p&gt;This article is highlighted in the In This Issue feature, p. 377&lt;/p&gt;&lt;/div&gt;
The "micromorph" solar cell: extending a-Si:H technology towards thin film crystalline silicon (1996)

Progress of solar cells based on plasma deposited hydrogenated microcrystalline silicon (/spl mu/c-Si:H), as well as on combined a-Si:H//spl mu/c-Si:H stacked "micromorph" solar cells is reported. /spl mu/c-Si:H p-i-n cells with a thickness of 3.6 /spl mu/m, deposited with the use of a gas-purifier, are shown to have a short-circuit current of over 25 mA/cm/sup 2/, and a stable efficiency of 7.7%. a-Si:H//spl mu/c-Si:H tandem cells with 13% initial, and with 10% degraded state efficiency are also demonstrated. In addition, methods to further increase the efficiency of combined a-Si:H//spl mu/c-Si:H solar cells are discussed. This includes the introduction of a ZnO reflector layer between a-Si:H and /spl mu/c-Si:H component cells, a new concept of which first experimental results are given.
Second-Generation Antiandrogen for Advanced Prostate Cancer (2012)

Recent understanding of the structure and function of the androgen receptor and insights into the phenomenon of resistance to testosterone suppression
Being Here: Enhancing the Presence of a Remote Person through Real-Time Display Integration of the Remote Figure and the Local Background (2012)

-Videoconferencing continues to emerge as a popular means of connecting remote participants. One of its goals is to establish a sense of presence through video imagery. One way to achieve a highly realistic presence is to generate a life-sized image of a remote person on a large display. However, in this case, the display conceals a large region of the local person’s front view, and replaces it with the remote site background. This may affect the viewer’s sense of the remote person’s presence. To resolve these conflicting effects, we propose a method involving the superimposition of the remote person’s figure on the local site front view. In this way, the local person may feel as though the remote person is before him/her in his/her spatial environment. The method has been implemented in the Being Here System accordingly. A system evaluation experiment revealed that the proposed method significantly enhanced the perceived presence of the remote person, in comparison with conventional videoconferencing.
Language and cognition influence on evolution of cultures (2011)

Abstract Evolution of cultures is influenced by languages. To understand this influence the paper analyzes how language and cognition interact in thinking. Is language just used for communication of completed thoughts, or is it fundamental for thinking? We review a hypothesis that language and cognition are two separate but closely interacting mechanisms, and identify each of them. Language accumulates cultural wisdom; cognition develops mental representations modeling surrounding world and adapts cultural knowledge to concrete circumstances of life. Language is acquired from surrounding language ‘ready-made’ and therefore can be acquired early in life. Cognition can not be acquired directly from experience; language is a necessary intermediary, a “teacher.” This model is consistent with recent neuroimaging data about cognition, remaining unnoticed by other theories. The proposed theory explains a number of properties of language and cognition, which previously seemed mysterious. It suggests mechanisms by which language grammars influence emotionality of languages and directs cultural evolution. This theory may explain specifics of English and Arabic cultures. We review theoretical and experimental evidence and discuss future directions
Novel Approach of MALDI Drug Imaging, Immunohistochemistry, and Digital Image Analysis for Drug Distribution Studies in Tissues (2014)

Drug efficacy strongly depends on the presence of the drug substance at the target site. As vascularization is an important factor for the distribution of drugs in tissues, we analyzed drug distribution as a function of blood vessel localization in tumor tissue. To explore distribution of the anticancer drugs afatinib, erlotinib, and sorafenib, a combined approach of matrix-assisted laser desorption/ionization (MALDI) drug imaging and immunohistochemical vessel staining was applied and examined by digital image analysis. The following two xenograft models were investigated: (1) mice carrying squamous cell carcinoma (FaDu) xenografts (ntumor = 13) were treated with afatinib or erlotinib, and (2) sarcoma (A673) xenograft bearing mice (ntumor = 8) received sorafenib treatment. MALDI drug imaging revealed a heterogeneous distribution of all anticancer drugs. The tumor regions containing high drug levels were associated with a higher degree of vascularization than the regions without drug signals (p < 0.05). When correlating the impact of blood vessel size to drug abundance in the sarcoma model, a higher amount of small vessels was detected in the tumor regions with high drug levels compared to the tumor regions with low drug levels (p < 0.05). With the analysis of coregistered MALDI imaging and CD31 immunohistochemical data by digital image analysis, we demonstrate for the first time the potential of correlating MALDI drug imaging and immunohistochemistry. Here we describe a specific and precise approach for correlating histological features and pharmacokinetic properties of drugs at microscopic level, which will provide information for the improvement of drug design, administration formula or treatment schemes.
ChemInform Abstract: γ‐Indomycinone, a New Pluramycin Metabolite from a Deep‐Sea Derived Actinomycete. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.