gebhart/patrepeval huggingface dataset:
Synthèse, structure et réactivité de nitrilimines stables (1990)

Les nitrilimines ont ete tres utilisees en synthese organique dans des cycloadditions dipolaires-1,3. Jusqu'a present, elles n'ont pu etre observees qu'en matrice a 77 k. Une methode de synthese originale nous a permis d'obtenir une nitrilimine stable a temperature ambiante (point de fusion de 100#oc sans decomposition): l'action du sel de lithium du bis (diisopropylamino)thiophosphinodiazomethane sur la bis(diisopropylamino) chlorophosphine conduit a la formation de la cbis(diisopropylamino) thiophosphino nbis(diisopropylamino) phosphino nitrilimine compose qui a fait l'objet d'une etude par diffraction de rayons x. Cette nitrilimine se rearrange thermiquement en son isomere diazoique. Ce resultat est la premiere mise en evidence directe de l'isomerisation nitrilimine-diazo. Sa reactivite met en evidence un caractere nucleophile. Les reactions de cycloadditions dipolaires 3+2 semblent tres regioselectives. Cependant, un manque de stereoselectivite a ete observe. Cette nitrilimine peut aussi reagir formellement sous forme de dipoles 1-4 avec des dipolarophiles tres pauvres en electrons. L'action de la tetrachloroorthobenzoquinone conduit a la formation d'un compose tres original et tres stable: un pseudo complexe de nitrene sur un atome d'oxygene. Nous avons mis en evidence un intermediaire stable a 50#oc, qui semble etre une isodiazirine, compose qui est le seul isomere jamais observe du diazomethane. Dans le cas d'addition du methyltriflate, nous obtenons la premiere nitrilimine electrophile stable dont la structure a ete etudiee par diffraction de rayons x
Wavelength-Tunable IR Detector based on Suspended Bilayer Graphene Micro Ribbons (2013)

Abstract : The original goal of this three-year project was to investigate bandgap-tunable bilayer-graphene microribbons allowing continuously tunable photodetection in the IR bands. Due to the government sequestration, the 2nd and 3rd years increments toward this project have been defunded. Here we are using our 1st year result as our final performance report. To this end we designed, fabricated, and characterized in Year One a device with suspended graphene microribbons, and found that fully suspended CVD-grown graphene devices are dominated by the photoelectric effect, which is promising towards CVD-grown graphene photodetectors approaching THz cut-off frequencies.
The performance of camera translation direction estimators from optical flow: analysis, comparison, and theoretical limits (1996)

A noniterative method using optical flow to recover the translation direction of a moving camera has been previously proposed by Heeger-Jepson (1992). In this paper we present a detailed explanation of the bias in this algorithm and compare methods for eliminating this bias, as well as presenting a comprehensive error analysis. This analysis includes a necessary modification to the Cramer-Rao lower bound (CRLB), We propose a simple iterative modification to the algorithm which produces unbiased translation direction estimates that approach the CRLB. Numerical results are used to compare the various techniques on synthetic and real image sequences.
Radar-Based Human Target Detection using Deep Residual U-Net for Smart Home Applications (2019)

We present a radar-based detection processing framework for accurate detection and counting of human targets in an indoor environment. This can be used to control lighting, heating, ventilation and air conditioning (HVAC) in smart homes and other presence related loads in commercial, office, and public spaces. Such smart home applications can facilitate monitoring, controlling, and saving energy. Conventionally, the radar range-Doppler processing pipeline includes moving target indicators (MTI) to remove static targets, maximal ratio combining (MRC) to integrate data across antennas, constant false alarm rate (CFAR) based detectors and then clustering algorithms to generate the target range-Doppler detections. However, the conventional pipeline suffers from ghost targets and multi-path reflections from static objects such as walls, furniture, etc. Further, conventional parametric clustering algorithms lead to single target splits and adjacent target merges in the target range-Doppler detections. To overcome such issues, we propose a deep residual U-net architecture that generates human target detections directly from static target removed range-Doppler images (RDI). To train this network, we record RDIs from a variety of indoor scenes with different configurations and multiple humans targets. We devise a custom loss function and apply augmentation strategies to generalize this model during real-time inference of the model. We demonstrate that the proposed network can efficiently learn to detect and correctly count human targets under different indoor environments while the conventional signal processing pipeline fails.
Elongation Behavior of Calcaneofibular and Cervical Ligaments in a Closed Kinetic Chain: Pathomechanics of Lateral Hindfoot Instability (2002)

Numerous reconstructive procedures are performed to correct both ankle and subtalar instability after trauma although the precise pathology which results in this chronic instability and pain is not yet known. This study examined the role of the calcaneofibular (CLFL) and cervical ligaments (CRVL) during physiologic loading and demonstrated the effect of CLFL deficiency on the CRVL. Talar and subtalar tilt as well as inversion range of motion before and after CLFL sectioning were studied. Eleven osteoligamentous fresh frozen cadaver legs were used in which each foot was taken through six positions: neutral, 35 degrees plantarflexion, dorsiflexion, inversion, plantarflexion-inversion, and dorsiflexion-inversion. The CLFL and CRVL stretched the greatest in dorsiflexion-inversion. The most interesting finding was that the CRVL was elongated relative to neutral in all other test positions of the foot. However, the CLFL was shortened relative to neutral in plantarflexion and plantarflexion-inversion. In the CLFL deficient state, CRVL ratios demonstrated significant increases in length of the CRVL. Talar tilt increased on average more than 9 degrees with CLFL deficiency (p < 0.008) while subtalar tilt did not change significantly. The maximum tibiocalcaneal angle, recorded for dorsiflexion-inversion, increased more than 5 degrees after sectioning the CLFL (p < 0.05).
Whole‐cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC (2000)

This study describes properties of monovalent cation currents through ECaC, a recently cloned epithelial Ca2+-permeable channel from rabbit. The kinetics of currents through ECaC was strongly modulated by divalent cations. Currents were inhibited in the presence of extracellular Ca2+. They showed an initial voltage-dependent decay in the presence of mM Mg2+ at hyperpolarizing steps in Ca2+-free solutions, which represents a voltage-dependent Mg2+ block through binding of Mg2+ to a site localized in the electrical field of the membrane (delta = 0.31) and a voltage-dependent binding constant (at 0 mV 3.1 mM Ca2+, obtained from a Woodhull type analysis). Currents were only stable in the absence of divalent cations and showed under these conditions a small time- and voltage-dependent component of activation. Single channel currents in cell-attached and inside-out patches had a conductance of 77.5 +/- 4.9 pS (n = 11) and reversed at +14.8 +/- 1. 6 11imV81i (n = 9) in the absence of divalent cations. The permeation sequence for monovalent cations through ECaC was Na+ > Li+ > K+ > Cs+ > NMDG+ which is identical to the Eisenmann sequence X for a strong field-strength binding site. It is concluded that the permeation profile of ECaC for monovalent cations suggests a strong field-strength binding site that may be involved in Ca2+ permeation and Mg2+ block.
Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM‐1 (2022)

Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration "hotspot" regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events. Using the photoconvertible probe mEos4b, we traced back and identified original endothelial transmigration hotspots. Using this method, we show that the heterogeneous distribution of ICAM-1 determines the location of the transmigration hotspot. Interestingly, the loss of ICAM-1 heterogeneity either by CRISPR/Cas9-induced knockout of ICAM-1 or equalizing the distribution of ICAM-1 in all endothelial cells results in the loss of TEM hotspots but not necessarily in reduced TEM events. Functionally, the loss of endothelial hotspots results in increased vascular leakage during TEM. Mechanistically, we demonstrate that the 3 extracellular Ig-like domains of ICAM-1 are crucial for hotspot recognition. However, the intracellular tail of ICAM-1 and the 4<sup>th</sup> Ig-like dimerization domain are not involved, indicating that intracellular signaling or ICAM-1 dimerization is not required for hotspot recognition. Together, we discovered that hotspots function to limit vascular leakage during inflammation-induced extravasation.
Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. (1987)

We have isolated a yeast conditional mutant which rapidly ceases synthesis of mRNA when subjected to the nonpermissive temperature. This mutant (rpb1-1) was constructed by replacing the wild-type chromosomal copy of the gene encoding the largest subunit of RNA polymerase II with one mutagenized in vitro. The rapid cessation of mRNA synthesis in vivo and the lack of RNA polymerase II activity in crude extracts indicate that the mutant possesses a functionally defective, rather than an assembly-defective, RNA polymerase II. The shutdown in mRNA synthesis in the rpb1-1 mutant has pleiotropic effects on the synthesis of other RNAs and on the heat shock response. This mutant provides direct evidence that the RPB1 protein has a functional role in mRNA synthesis.
ChemInform Abstract: BIS(DITHIO DIIRONHEXACARBONYL)GERMANIUM (1977)

Abstract Dithio‐dieisen‐hexacarbonyl (I) bildet mit der Trichlorgerman‐äther‐Komplexverbindung (II) das orangefarbene, kristalline Dithio‐dieisen‐hexacarbonyl‐germaniumdichlorid (III).
Ideal and nonideal invisibility cloaks (2008)

We employ the analytical solutions for the spatial transformation of the electromagnetic fields to obtain and analyze explicit expressions for the structure of the electromagnetic fields in invisibility cloaks. Similar approach can be also used for analyzing beam splitters and field concentrators. We study the efficiency of nonideal electromagnetic cloaks and discuss the effect of scattering losses on the cloak invisibility.
RCY1-Mediated Resistance to Cucumber mosaic virus Is Regulated by LRR Domain-Mediated Interaction with CMV(Y) Following Degradation of RCY1 (2012)

RCY1, which encodes a coiled coil nucleotide-binding site leucine-rich repeat (LRR) class R protein, confers the hypersensitive response (HR) to a yellow strain of Cucumber mosaic virus (CMV[Y]) in Arabidopsis thaliana. Nicotiana benthamiana transformed with hemagglutinin (HA) epitope-tagged RCY1 (RCY1-HA) also exhibited a defense response accompanied by HR cell death and induction of defense-related gene expression in response to CMV(Y). Following transient expression of RCY1-HA by agroinfiltration, the defense reaction was induced in N. benthamiana leaves infected with CMV(Y) but not in virulent CMV(B2)-infected N. benthamiana leaves transiently expressing RCY1-HA or CMV(Y)-infected N. benthamiana leaves transiently expressing HA-tagged RPP8 (RPP8-HA), which is allelic to RCY1. This result suggests that Arabidopsis RCY1-conferred resistance to CMV(Y) could be reproduced in N. benthamiana leaves in a gene-for-gene manner. Expression of a series of chimeric constructs between RCY1-HA and RPP8-HA in CMV(Y)-infected N. benthamiana indicated that induction of defense responses to CMV(Y) is regulated by the LRR domain of RCY1. Interestingly, in CMV(Y)-infected N. benthamiana manifesting the defense response, the levels of both RCY1 and chimeric proteins harboring the RCY1 LRR domain were significantly reduced. Taken together, these data indicate that the RCY1-conferred resistance response to CMV(Y) is regulated by an LRR domain-mediated interaction with CMV(Y) and seems to be tightly associated with the degradation of RCY1 in response to CMV(Y).
Plate Acoustic Waves in ZX-cut Lithium Niobate (2007)

Plate acoustic waves (PAW) propagating along X-axis in the Z-cut wafer of a single crystal of lithium niobate are considered theoretically and experimentally. For eight lowest PAW modes, the dispersion curves for wavenumber k(f) are calculated by the equations of motion and electrodynamics, by the Finite Element Method, and then measured experimentally. The spectra k(f) obtained by the numerical solution and FEM-simulation are in good agreement, and experimental measurements agree with theoretical predictions. The PAW modes are identified by the components of their total acoustic displacements and cutoff frequencies. Analysis of the longitudinal and normal acoustical displacements permits to find PAW mode capable for usage in ultrasonic actuators. The results obtained may be useful for ultrasonic transducers, acousto-electronic and acousto-optic applications, and ultrasonic motors/actuators fabricated in the Z-cut ferroelectric lithium niobate wafers including periodically poled wave-guides.
Powder Metallurgy of Superalloys (1974)

Nickel-chromium and, to a lesser extent, cobalt-chromium alloys are the major class of materials used for the high temperature components of aircraft, marine, and land-based power systems and are also utilized in applications, such as hot-working tools and dies. The successful application of these alloys, now commonly termed ‘superalloys’, is due to their high, long-time creep strength and stability at elevated temperatures combined with their outstanding resistance to corrosion (often with protective coatings) in the aggressive environments encountered during service.
Structural analysis of a transatmospheric beam-boosted, super-pressure aerospacecraft (1996)

The principal objective of this work is to investigate the conceptual design and finite element structural analysis (FEM) of a hyper-energetic beam-boosted aerospacecraft capable of transporting 12 occupants around the planet (and back), into low Earth orbit, or directly to the Moon without resorting to refueling or staging. As proposed, the double-hull of the 20-m diameter super-pressure balloon-type craft may be constructed from microwave-transparent silicon carbide films of superior strength (i.e., thin films with properties equal to our best carbon fibers), and inflated with two atmospheres of helium. The addition of an oxygen partial pressure of 69-mm of Hg, makes this a breathable mixture for the crew. Exotic thin-film and composite fabrication methods are employed to achieve extreme light weight (2400-kg) and structural stability. The lenticular spacecraft design is dominated by the magnetohydrodynamic (MHD) propulsion system geometry, and by human factors requirements. The remote beam- energized MHD powerplant is intimately integrated with the crafts tensile-type structure, and is not distinguishable as an item separate from the vehicle as in conventional aircraft. The design assumption of liquid immersion G-suits, partial liquid ventilation,
Learning and feedback from the Danish patient safety incident reporting system can be improved. (2016)

not relevant.
Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera (2016)

Our results demonstrate that the uPAR-targeted, saporin-based recombinant fusion ATF-SAP can be produced in a fed-batch fermentation with full retention of the molecules selective cytotoxicity and hence therapeutic potential.
Over-Mutated Mitochondrial, Lysosomal and TFEB-Regulated Genes in Parkinson’s Disease (2022)

The association between Parkinson's disease (PD) and mutations in genes involved in lysosomal and mitochondrial function has been previously reported. However, little is known about the involvement of other genes or cellular mechanisms. We aim to identify novel genetic associations to better understand the pathogenesis of PD. We performed WES in a cohort of 32 PD patients and 30 age-matched controls. We searched for rare variants in 1667 genes: PD-associated, related to lysosomal function and mitochondrial function and TFEB-regulated. When comparing the PD patient cohort with that of age matched controls, a statistically significant burden of rare variants in the previous group of genes were identified. In addition, the Z-score calculation, using the European population database (GnomAD), showed an over-representation of particular variants in 36 genes. Interestingly, 11 of these genes are implicated in mitochondrial function and 18 are TFEB-regulated genes. Our results suggest, for the first time, an involvement of TFEB-regulated genes in the genetic susceptibility to PD. This is remarkable as TFEB factor has been reported to be sequestered inside Lewy bodies, pointing to a role of TFEB in the pathogenesis of PD. Our data also reinforce the involvement of lysosomal and mitochondrial mechanisms in PD.
Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets (2016)

Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and counterproductive. This report presents the case of a 77-year-old Caucasian male with extensive-stage refractory SCLC who was restarted on platinum doublets as part of a clinical trial called TRIPLE THREAT (NCT02489903) involving pretreatment with the epi-immunotherapeutic agent RRx-001, and who achieved a partial response after only 4 cycles. The patient had received a platinum drug twice before, in 2009 for a diagnosis of non-small-cell lung cancer (squamous cell carcinoma) and in 2015 for SCLC, suggesting that RRx-001 pretreatment may sensitize or resensitize refractory SCLC patients to first-line chemotherapy.
Power Quality Improvement with Active Load Management (ALM) (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-1421.vid Specialized functionalities in an aircraft power system often require dedicated hardware that are only operated during distinct mission segments and are otherwise inactive. Active load management can utilize these loads during dormancy to improve power quality with zero to minimal volume and weight cost to the aircraft. The feasibility of applying active load management to improve power quality was explored in this paper for a typical aircraft electrical power system (EPS). Electrical power quality improvement was achieved through minimal redesign and the lessons learnt have been used to develop a general guideline for other power systems.
Principles of fixation of osteoporotic fractures (2006)

Despite advances in the prevention and treatment of osteoporotic fractures, their prevalence continues to increase. Their operative treatment remains a challenge for the surgeon, often with unpredictable outcomes. This review highlights the current aspects of management of these fractures and focuses on advances in implant design and surgical technique.
COMMENTARY The tenascin-C knockout revisited (1999)

In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities. More recent studies, many involving pathological intervention, have shown that tenascin-Cknockout mice have several defects. The mice exhibit abnormal behaviour, as well as abnormalities in brain chemistry. They also show defects in structure and repair of neuromuscular junctions, in the ability to recover from snake-venom-induced glomerulonephritis and in chemically induced dermatitis. Healing of skin wounds is morphologically normal, but the mice exhibit defects in healing after suture injury of corneas. In both skin and corneal wounds, fibronectin expression is abnormally low in tenascin-C-knockout mice. Finally, in vitro studies indicate that haemopoietic activity is defective in bone marrow from these mice. When examined together, these studies provide evidence for precise functions for tenascinC, as well as an explanation for why the sequence of tenascin-C is so highly phylogenetically conserved. SUMMARY
A randomized trial of naltrexone for smoking cessation (1999)

The opioid antagonist naltrexone was not found to be effective for smoking cessation and had no significant effect on daily cigarette consumption or craving. The results of the present study provide no support for the use of naltrexone, alone or in combination with nicotine patches, as a therapeutic treatment for smoking cessation.
5-Hydroxytryptamine release in vivo from a cytoplasmic pool: studies on the 5-HT behavioural syndrome in reserpinized rats. (1985)

Treatment of rats with reserpine in order to disrupt vesicular amine storage reduces 5-hydroxytryptamine (5-HT) levels throughout brain by 90-95%. Despite the drastic reduction in brain 5-HT content by reserpine, the 5-HT releasing drug p-chloramphetamine (PCA) produces a behavioural syndrome in reserpine-treated rats which is not different from that observed in normal animals given PCA. Prior treatment of reserpinized rats with p-chlorophenylalanine (PCPA), the irreversible tryptophan hydroxylase inhibitor which inhibits the synthesis of new 5-HT, prevents the PCA-induced behavioural syndrome. The 5-HT receptor antagonist methergoline, blocks the PCA effect in reserpine-treated rats. Treatment of reserpinized rats with pargyline, a non-selective inhibitor of monoamine oxidase, in order to increase cerebral 5-HT levels, shifts the PCA dose-response curve for inducing the 5-HT behavioural syndrome to the left. The specific 5-HT uptake blocker, fluoxetine, protects normal and reserpine-treated rats from the 5-HT depleting effects of PCA but does not always prevent the PCA-induced 5-HT behavioural syndrome. These results indicate that PCA releases 5-HT into the synapse from a small cytoplasmic pool which is resistant to reserpine and suggest that this newly synthesized compartment of 5-HT represents the 'functional' transmitter pool.
The Catalysis of Palladium and Cupric Ion-exchanged Zeolite for Oxidation of Ethylene (1976)

Oxidation reactions of ethylene over zeolite loaded with Pd(II) and/or Cu(II) by way of ion exchange were studied in the presence of steam. Neither Pd(II)-zeolite nor Cu(II)-zeolite had good catalytic activity for oxidation of ethylene to acetaldehyde. However, the dual ion catalysts, namely, Pd(II)-Cu(II)-zeolites which were prepared by various ion exchange methods, were found highly active and selective for oxidation of ethylene to acetaldehyde. The degree of conversion of olefins under the same experimental conditions was in the order: ethylene>propylene>1-butene>cis-2-butene≈trans-2-butene. The reaction mechanism was discussed in analogy with that of Wacker-reaction.