gebhart/patrepeval huggingface dataset:
Development and Validation of a Thermal Model for Electric Induction Motors (2010)

A transient lumped-parameter thermal model of an induction motor is developed. The energy balances and the expressions for the appropriate node couplings representing conduction and convection heat transfer between nodes, as well as the expressions for the heat capacity of each node, are presented. We also present expressions used in a Second Law analysis to calculate the entropy generation and exergy destruction rates at each node. An overall Second Law efficiency for heat transfer through the motor is then defined. The model is validated by comparing calculated temperatures with experimental data for a motor driving an electric submersible pump, showing that the lumped-parameter approximation is sufficient to accurately calculate temperature distributions in the motor and to capture temperature changes during warm-up and cooldown. Finally, the Second Law analysis is used to determine which components in the motor are contributing most to the inefficiency of the heat transfer process, providing a diagnostic tool for identification of areas in the motor where potential heat transfer enhancements would be most beneficial.
Pseudomonas aeruginosa -Mediated Damage Requires Distinct Receptors at the Apical and Basolateral Surfaces of the Polarized Epithelium (2009)

Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basolateral (BL) surfaces of polarized epithelium. We demonstrate that the N-glycan chains at the AP surface are necessary and sufficient for binding, invasion, and cytotoxicity to kidney (MDCK) and airway (Calu-3) cells grown at various states of polarization on Transwell filters. Upregulation of N-glycosylation enhanced binding, whereas pharmacologic inhibition of N-glycosylation or infection of MDCK cells defective in N-glycosylation resulted in decreased binding. In contrast, at the BL surface, the HS moiety of HSPGs mediated P. aeruginosa binding, cytotoxicity, and invasion. In incompletely polarized epithelium, HSPG abundance was increased at the AP surface, explaining its increased susceptibility to P. aeruginosa colonization and damage. Using MDCK cells grown as three-dimensional cysts as a model for epithelial organs, we show that P. aeruginosa specifically colocalized with HS-rich areas at the BL membrane but with complex N-glycans at the AP surface. Finally, P. aeruginosa bound to HS chains and N-glycans coated on plastic surfaces, showing the highest binding affinity toward isolated HS chains. Together, these findings demonstrate that P. aeruginosa recognizes distinct receptors on the AP and BL surfaces of polarized epithelium. Changes in the composition of N-glycan chains and/or in the distribution of HSPGs may explain the enhanced susceptibility of damaged epithelium to P. aeruginosa.
The Drying of solids—II (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Drying of solids—IIT. K. SherwoodCite this: Ind. Eng. Chem. 1929, 21, 10, 976–980Publication Date (Print):October 1, 1929Publication History Published online1 May 2002Published inissue 1 October 1929https://pubs.acs.org/doi/10.1021/ie50238a021https://doi.org/10.1021/ie50238a021research-articleACS PublicationsRequest reuse permissionsArticle Views778Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Hermunculus: What Is Known about the Representation of the Female Body in the Brain? (2012)

The representation of the body in the brain, the homunculus, was posited by Wilder Penfield based on his studies of patients with intractable epilepsy. While he mapped both male and female patients, Penfield reports little about the females. The now iconic illustration of the map is clearly male with testicles, penis, and no breasts. In order to bring attention to this omission and to stimulate studies of female somatosensory cortex (SS), we discuss what is known about the map of the female body in the brain, including Penfield's findings in his female patients and subsequent work by others exploring the human female SS. We reveal that there is much we do not know about how the entire female body is represented in the brain or how it might change with different reproductive life stages, hormones, and experiences. Understanding what is and is not currently known about the female SS is a first step toward fully understanding neurological and physiological sex differences, as well as producing better-informed treatments for pain conditions related to mastectomy, hysterectomy, vulvodynia, and fibromyalgia. We suggest that the time is ripe for a full mapping of the female brain with the production of a hermunculus.
SD-208, a Novel Transforming Growth Factor Beta Receptor I Kinase Inhibitor, Can Stimulate Hematopoiesis in Myelodysplastic Syndrome Progenitors. (2005)

Abstract Transforming Growth Factor β (TGF-β) is a myelosuppressive cytokine that has been implicated in the ineffective hematopoiesis seen in myelodysplastic syndromes (MDS). Overactivation of TGF-β signaling in this disease was demonstrated immunohistochemically by significantly higher nuclear SMAD2 phosphorylation observed in 20 MDS bone marrows when compared with 7 non MDS anemic controls (P &amp;lt; 0.0001, 2 Tailed T Test, Image Pro Plus software). This data along with high levels of membrane-bound and plasma TGF-β observed in MDS patients in previous studies support the development of therapeutics targeting the TGF-β signaling pathways in this disease. SD-208 is a novel, potent and specific inhibitor of TGF-β Receptor I (TGFβ-RI) kinase. We demonstrate that SD-208 blocks the phosphorylation of SMAD2 in hematopoietic progenitors which are at the colony forming unit-erythroid (CFU-E) stage of differentiation. SD-208 also abrogates the G0/G1 cell cycle arrest induced by TGF-β in bone marrow progenitors. SD-208 treatment leads to reversal of the myelosuppressive effects of TGF-β on erythroid and myeloid colony formation from primary human CD34+ cells. Selectivity of SD-208 in inhibiting TGF-β-mediated effects on hematopoiesis was supported by similar results observed with siRNAs targeting SMAD2, a major component of the TGF-b signaling pathway. Finally, the efficacy of SD-208 in MDS was evaluated by treating bone marrow mononuclear cells from 15 patients with early low grade MDS. SD-208 treatment led to dose-dependent increases in erythroid and myeloid colonies after 14 days of in vitro culture. The effect was most notable in patients with high levels of activated SMAD-2, as assessed by immunohistochemical staining of bone marrow biopsies. Stimulation of hematopoiesis in MDS-derived marrow culture by SD-208 demonstrates a novel concept and potential therapeutic role for TGFβ-RI inhibition in this disease. Supported by VISN-17 grant, Harris Methodist Foundation Grant and ASCO YIA to AV
AZD8931, an Equipotent, Reversible Inhibitor of Signaling by Epidermal Growth Factor Receptor, ERBB2 (HER2), and ERBB3: A Unique Agent for Simultaneous ERBB Receptor Blockade in Cancer (2010)

AZD8931 has a unique pharmacologic profile providing equipotent inhibition of EGFR, erbB2, and erbB3 signaling and showing greater antitumor activity than agents with a narrower spectrum of erbB receptor inhibition in specific preclinical models. AZD8931 provides the opportunity to investigate whether simultaneous inhibition of erbB receptor signaling could be of utility in the clinic, particularly in the majority of solid tumors that do not overexpress erbB2.
Supplementary Data from Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma (2023)

&lt;p&gt;Supplementary Materials and Methods, Supplementary Figures and Supplementary Tables&lt;/p&gt;
SURG-07. Plasmonic gold nanostars to increase the efficiency and specificity of laser interstitial thermal therapy (LITT) in the treatment of brain tumors (2021)

Abstract Introduction Laser interstitial thermal therapy (LITT) is an effective minimally-invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within intracranial tumors and amplify the ablative capacity of LITT while better conforming to tumor boundaries and protecting surrounding tissue. Materials and Methods: The 12nm GNS were synthesized using reduced HAuCl4 with Na3C6H5O7 seeds, mixed with AgNO3, C6H8O6, and HAuCL4, and coated with polyethylene glycol then functionalized with methoxy PEG thiol. CT-2A glioma cells were intracranially implanted into mice, followed 18 days later by IV injection of GNS. PET-CT was performed at 10-minutes, 24-, and 72-hours post-GNS administration, with autoradiography (AR) and histopathology (HP) on sacrifice after the last scan. To test the impact of GNS on LITT coverage capacity in appropriately sized ex vivo models, we utilized agarose gel-based phantoms incorporating control and GNS-infused central “tumors” in multiple shapes. LITT was administered with the NeuroBlate System. Results In vivo, GNS preferentially accumulated within intracranial tumors on PET-CT at the 24- and 72-hour timepoints. AR and HP confirmed high GNS accumulation within tumor. Ex vivo, in cuboid tumor phantoms, the GNS-infused phantom heated 5.5x faster than the control, rising 0.49°C per minute compared to 0.09°C. In a split-cylinder tumor phantom with half containing GNS, the GNS-infused border heated 2x faster and the surrounding area was exposed to 30% lower temperatures. In a GNS-infused star-shaped phantom, the heat spread contoured along phantom boundaries. Conclusion Our results provide evidence for use of GNS to improve the specificity, efficiency, and potentially safety of LITT. The in vivo data support selective accumulation within intracranial tumors, and the GNS-infused phantom experiments demonstrate increased rates of heating within the tumor model, heat contouring to tumor borders, and decreased heating of surrounding regions representing normal structures.
Laser-driven compact free electron laser: from extreme ultraviolet radiation to x-rays (2021)

Combination of revolutionary high-repetition-rate high-power laser technology and the latest achievements in laser-plasma accelerators (LPAs) opens the way to develop a new generation of laser-driven compact free-electron lasers (FEL). The LPA electron beam brightness is extremely high due to a low normalized emittance (less than 0.5 µm) and high peak current (multi kA), resulting from an ultra-short e-beam duration (few fsec), which makes such beam extremely attractive for the production of high power pulses of the coherent photon radiation. In the frame of this report, we overview the laser-driven FEL research program at ELI-Beamlines (near Prague, Czech Republic), which aims to demonstrate the self-amplified spontaneous emission (SASE) regime with a generation of the coherent photon radiation starting from the extreme ultraviolet wavelength range. A possible extension of this research program to the X-ray FEL regime will be discussed.
Molecular Diagnosis of Human Enteroviruses by Phylogeny‐Based Classification by Use of the VP4 Sequence (2002)

Human enteroviruses (EVs) are the major cause of a variety of acute and chronic illnesses. Virus isolation and neutralization tests are usually done to identify the causative virus, but these tests are labor intensive, time consuming, and sometimes require suckling mice from which certain viruses have been isolated. This study investigated a rapid and reliable method based on reverse-transcription polymerase chain reaction and phylogenetic analysis. The phylogenetic tree constructed by neighbor-joining on the basis of the VP4 sequence from 66 prototypes grouped all human EVs into 5 distinct clusters. These clusters correspond closely to the 5 newly designated species-human EV A-D and poliovirus. The VP4 sequences of 89 isolates from 26 serotypes obtained over >30 years plus those of 66 prototype strains were analyzed. Each isolate formed a monophyletic cluster along with its respective prototype strain, allowing for serotype identification (with the exception of E-8). VP4-based classification appears to be an effective tool for the molecular epidemiology study of EVs.
Weight loss by calorie restriction versus bariatric surgery differentially regulates the hypothalamo-pituitary-adrenocortical axis in male rats (2014)

Behavioral modifications for the treatment of obesity, including caloric restriction, have notoriously low long-term success rates relative to bariatric weight-loss surgery. The reasons for the difference in sustained weight loss are not clear. One possibility is that caloric restriction alone activates the stress-responsive hypothalamo-pituitary-adrenocortical (HPA) axis, undermining the long-term maintenance of weight loss, and that this is abrogated after bariatric surgery. Accordingly, we compared the HPA response to weight loss in five groups of male rats: (1) high-fat diet-induced obese (DIO) rats treated with Roux-en-Y gastric bypass surgery (RYGB, n = 7), (2) DIO rats treated with vertical sleeve gastrectomy (VSG, n = 11), (3) DIO rats given sham surgery and subsequently restricted to the food intake of the VSG/RYGB groups (Pair-fed, n = 11), (4) ad libitum-fed DIO rats given sham surgery (Obese, n = 11) and (5) ad libitum chow-fed rats given sham surgery (Lean, n = 12). Compared with Lean controls, food-restricted rats exhibited elevated morning (nadir) non-stress plasma corticosterone concentration and increased hypothalamic corticotropin-releasing hormone and vasopressin mRNA expression, indicative of basal HPA activation. This was largely prevented when weight loss was achieved by bariatric surgery. DIO increased HPA activation by acute (novel environment) stress and this was diminished by bariatric surgery-, but not pair-feeding-, induced weight loss. These results indicate that the HPA axis is differentially affected by weight loss from caloric restriction versus bariatric surgery, and this may contribute to the differing long-term effectiveness of these two weight-loss approaches.
Segmentation of dense depth maps using inertial data a real-time implementation (2003)

We propose a real-time system that extracts information from dense relative depth maps. This method enables the integration of depth cues on higher level processes including segmentation of structures, object recognition, robot navigation or any other task that requires a 3D representation of the physical environment. Inertial sensors coupled to a vision system can provide important inertial cues for the ego-motion and system pose. In this work we explore the integration of inertial sensor data in vision systems. Depth maps obtained by vision systems, are very point of view dependant, providing discrete layers of detected depth aligned with the camera. We use inertial sensors to recover the camera pose, and rectify the maps to a reference ground plane, enabling the segmentation of vertical and horizontal geometric features. The aim of this work is a fast real-time system, so that it can be applied to autonomous robotic systems or to automated car driving systems, for modelling the road, identifying obstacles and roadside features in real-time.
A Technique for Estimating the Difficulty of a Formal Verification Problem (2006)

In this paper a technique is proposed to estimate the level of difficulty of formally verifying an RTL circuit. The technique is based on extensive experimental data generated from a wide range of industrial and academic benchmarks. Statistical as well as intuitive inferences have been drawn from the data to obtain an algorithm that can classify the level of difficulty of formally verifying a property on a particular circuit into five broad categories. The difficulty of verifying the whole circuit is a weighted average of the difficulty of verifying its individual properties. The level of coverage generated by the properties gives us a confidence level on the accuracy of the metric
Composite Score of Readiness (CSR) as a Data Reduction Technique for Monitoring the RTS Process in Footballers following ACL Reconstruction (2023)

In recent years, many studies on the safe return to sport (RTS) have been published, but there are still no clear and validated guidelines. After ACL reconstruction between limbs, asymmetry of muscle strength affects knee mechanics during walking and running, and asymmetrical joint kinematics and kinetics are considered as a strong risk factor of musculoskeletal injury. Therefore, proper diagnosis of any motor deficits remaining after ACL reconstruction seems particularly important. The aim of this study was to analyze how many tests should be included in the RTS test battery and which of them are most indicative for functional deficits related to anterior cruciate ligament (ACL) reconstruction. Sixty-five male football players (age 18–25 years) were divided into three groups: ACL group—after ACL rupture and reconstruction, mild injury group—post mild lower limb injuries, and the control group—without injuries. They performed five tests: Functional Movement Screen, Tuck Jump Assessment, Y-balance Test, Hop Test for Distance, and Isokinetic Test. The Composite Score of Readiness (CSR) index was calculated and expressed as the sum of z-scores. The multiple regression model for all tests was calculated, and then redundant variables were excluded. We observed that all tests significantly influenced the final CSR index. The Y-balance Test, Tuck Jump Assessment, and Isokinetic Test for knee flexion influenced the final CSR index the most, which means that these tests are greatly indicative of functional deficits related to ACL reconstruction. The strength of the extensor (quadriceps) muscle and the quadriceps/hamstring ratio appeared to be non-sensitive for testing functional deficits related to ACL reconstruction. If the test battery includes 4–5 tests, it better differentiates the athletes following ACL reconstruction from those after mild injuries, even if they all were cleared to play.
Pressurization of Vertebral Bodies During Vertebroplasty Causes Cardiovascular Complications (2003)

An experimental study of cardiovascular complications arising during vertebroplasty (VP) of multiple levels in sheep.To investigate the effect of pressurizing vertebral bodies during VP using different materials in the development of fat embolism (FE) and any associated cardiovascular changes.Polymethylmethacrylate (PMMA) is the material of choice for VP. However, PMMA has several disadvantages, such as toxicity, exothermic curing, uncertain long-term biomechanical effects, and biocompatibility. Alternative materials are being developed for VP; however, there is the concern that an increase in intraosseous pressure and displacement of bone marrow contents could lead to FE and hypotension during VP regardless of what type of materials is used.In 20 sheep, four vertebral bodies were augmented either with PMMA or bone wax. Heart rate; arterial, central venous, and pulmonary artery pressure; cardiac output; and blood gas values were recorded. Postmortem the lungs were subjected to histologic evaluation.The consecutive augmentation of four vertebral bodies with PMMA induced a cumulative FE that gradually deteriorated baseline mean arterial blood pressure (MABP) and blood gas values. The augmentation with bone wax resulted in similar cardiovascular changes and amount of intravascular fat in the lungs.There are potential cardiovascular complications during VP of multiple levels regardless of the augmentation material used. The deteriorating baseline MABP during VP is associated with the pressurization of the vertebral bodies rather than with the use of polymethylmethacrylate.
AI-Based Network-Aware Service Function Chain Migration in 5G and Beyond Networks (2021)

While the 5G network technology is maturing and the number of commercial deployments is growing, the focus of the networking community is shifting to services and service delivery. 5G networks are designed to be a common platform for very distinct services with different characteristics. Network Slicing has been developed to offer service isolation between the different network offerings. Cloud-native services that are composed of a set of inter-dependent micro-services are assigned into their respective slices that usually span multiple service areas, network domains, and multiple data centers. Due to mobility events caused by moving end-users, slices with their assigned resources and services need to be re-scoped and re-provisioned. This leads to slice mobility whereby a slice moves between service areas and whereby the inter-dependent service and resources must be migrated to reduce system overhead and to ensure low-communication latency by following end-user mobility patterns. Recent advances in computational hardware, Artificial Intelligence, and Machine Learning have attracted interest within the communication community to study and experiment self-managed network slices. However, migrating a service instance of a slice remains an open and challenging process, given the needed co-ordination between inter-cloud resources, the dynamics, and constraints of inter-data center networks. For this purpose, we introduce a Deep Reinforcement Learning based agent that is using two different algorithms to optimize bandwidth allocations as well as to adjust the network usage to minimize slice migration overhead. We show that this approach results in significantly improved Quality of Experience. To validate our approach, we evaluate the agent under different configurations and in real-world settings and present the results.