gebhart/patrepeval huggingface dataset:
Isolation and characterization of bovine alphaherpesvirus 2 strain from an outbreak of bovine herpetic mammillitis in a dairy farm (2020)

The report represents a significant outbreak of BHM in a dairy farm 50 years after the last description in Italy. However, outbreaks of PLSD have been described in Europe recently, indicating that the virus is present in European territories. Improving the diagnostic algorithms and enacting specific surveillance plans could be useful to understand better the epidemiological and pathogenetic patterns of BoHV-2 infection in livestock animals, and to develop, eventually, effective prophylaxis plans.
NOx, SOx and CO2 Emissions Reduction from Continuous Commissioning® (CC®) Measures at the Rent-A-Car Facility in the Dallas-Fort Worth International Airport (2006)

The energy savings were evaluated thru weather normalized inverse modeling. Baseline data, pre-CC®, and the post-CC® data were modeled as a function of the weather. The electricity savings were calculated by the difference of the baseline model and the measured post-CC® data of the facility. Similarly, these models were applied to weather of 1999 and the potential savings at that year were documented. The documented savings at RAC were then converted to NOx, CO2, and SO2 emissions reduction on a tons/year and tons/peak-day basis using TCEQ/ESL’s emissions reduction methodology and EPA’s eGRID emissions data base.
Metformin and Pancreatic Cancer: A Clue Requiring Investigation (2012)

Laboratory models show antineoplastic activity of metformin under certain conditions, and pharmacoepidemiologic studies have reported reduced cancer burden among diabetics taking metformin. Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be "repurposed" for oncologic indications.
Hepatic Parenchymal Changes following Transcatheter Embolization and Chemoembolization in a Rabbit Tumor Model (2013)

The results of this animal study revealed that TACE induced prominent hepatocellular damage and hepatic fibrogenesis, which compromised liver function and may be responsible for chronic liver decompensation.
Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice (2019)

Emphysema is a significant feature of chronic obstructive pulmonary disease (COPD). Studies involving an emphysematous mouse model require optimal lung fixation to produce reliable histological specimens of the lung. Due to the nature of the lung's structural composition, which consists largely of air and tissue, there is a risk that it collapses or deflates during the fixation process. Various lung fixation methods exist, each of which has its own advantages and disadvantages. The lung fixation method presented here utilizes constant pressure to enable optimal tissue evaluation for studies using an emphysematous mouse lung model. The main advantage is that it can fix many lungs with the same condition at one time. Lung specimens are obtained from chronic cigarette smoke-exposed mice. Lung fixation is performed using specialized equipment that enables the production of constant pressure. This constant pressure maintains the lung in a reasonably inflated state. Thus, this method generates a histological specimen of the lung that is suitable to evaluate cigarette smoke-induced mild emphysema.
New materials for high gain optical limiters (2001)

Summary form only given. Practical optical limiters for use in high optical gain applications are nearing reality. These devices work principally via excited state absorption (also known as reverse saturable absorption, RSA) and are based on materials that have a large difference between the ground and excited state absorption cross sections. The ground state is nearly transparent while the excited state absorbs the incoming light strongly. Recently, we have synthesized a series of silicone substituted phthalocyanines capable of forming high optical quality pure thin films. The novelty of this class of materials is that the silicone substituents incorporate very large changes of the refractive index with temperature directly into the RSA material. Additionally, the silicone substituent yields very high solubility in many common solvents that allows the full characterization of the aggregation constant of the material. Aggregation of the phthalocyanine moieties in these materials can lead to shortened excited state lifetime, hence the degradation of the optical limiting performance. The linear, thermal, nonlinear optical and optical limiting properties of this new class of materials are described.
Supplementary Figure 4 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models (2023)

&lt;p&gt;PDF file - 231K, Ganetespib inhibits MET activity and downstream signaling in cells expressing TKI-sensitive MET mutants.&lt;/p&gt;
Formation of the Vascular Amyloid Fibril Protein Medin From its Precursor Lactadherin (2004)

The amyloid protein was, due to its localization to the media termed medin. Medin amyloid, one of the most common amyloids, affects the population. Medin amyloid is found predominantly in the inner part of the media layer. The mechanism by which medin is formed from lactadherin and if this event is normal or pathological are not known, nor are the consequences of the deposition on the surrounding tissue. Medin amyloid was often found close to the elastic lamina of the media of the aorta, and sometimes around the nuclei of smooth muscle cells. Confocal microscopy of Congo red stained frozen tissue sections clearly showed amyloid deposits within smooth muscle cells in the media layer of aorta, as well as extracellular amyloid. Intracellular medin amyloid was detected by confocal microscopy. Intracellular fibrillar deposits might be the start point of extracellular medin amyloid. Further experiments such as electron microscopy should be done to confirm the intracellular amyloid formation.
Collaboration and Sustainability: Making Science Useful, Making Useful Science (2020)

Collaboration is essential to produce the distinctive forms of science and technology—knowledge and know-how—required to meet sustainability challenges. What might be the form of that collaboration? One-shot or transient collaboration is giving way to richer, deeper, continual integration of knowledge, power, and diverse ethics and values (ethos), and these, in turn, confront leaders and analysts with new challenges.
eBay's Market Intermediation Problem (2012)

We study the optimal mechanism design problem faced by a market intermediary who makes revenue by connecting buyers and sellers. We first show that the optimal intermediation protocol has substantial structure: it is the solution to an algorithmic pricing problem in which seller's costs are replaced with virtual costs, and the sellers' payments need only depend on the buyer's behavior and not the buyer's actual valuation function. Since the underlying algorithmic pricing problem may be difficult to solve optimally, we study specific models of buyer behavior and give mechanisms with provable approximation guarantees. We show that offering only the single most profitable item for sale guarantees an $Ω(\frac1{\log n})$ fraction of the optimal revenue when item value distributions are independent and have monotone hazard rates. We also give constant factor approximations when the buyer considers all items at once, $k$ items at once, or items in sequence.
The Unusual Linear Plasmids of the Lyme Disease Spirochete Borrelia burgdorferi (2000)

Conference Abstract| October 01 2000 The Unusual Linear Plasmids of the Lyme Disease Spirochete Borrelia burgdorferi S. R. Casjens S. R. Casjens 1Dept. of Oncological Sciences, U. of Utah Medical School, Salt Lake City, UT 84132 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A102. https://doi.org/10.1042/bst028a102a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation S. R. Casjens; The Unusual Linear Plasmids of the Lyme Disease Spirochete Borrelia burgdorferi. Biochem Soc Trans 1 October 2000; 28 (5): A102. doi: https://doi.org/10.1042/bst028a102a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Semiotic prediction of driving behavior using unsupervised double articulation analyzer (2012)

In this paper, we propose a novel semiotic prediction method for driving behavior based on double articulation structure. It has been reported that predicting driving behavior from its multivariate time series behavior data by using machine learning methods, e.g., hybrid dynamical system, hidden Markov model and Gaussian mixture model, is difficult because a driver's behavior is affected by various contextual information. To overcome this problem, we assume that contextual information has a double articulation structure and develop a novel semiotic prediction method by extending nonparametric Bayesian unsupervised morphological analyzer. Effectiveness of our prediction method was evaluated using synthetic data and real driving data. In these experiments, the proposed method achieved long-term prediction 2-6 times longer than some conventional methods.
The role of the lateral extraarticular restraints in the anterior cruciate ligament-deficient knee (1993)

We measured the increases in tibiofemoral motion when lateral structures were sectioned in anterior cruciate ligament-deficient knees of 20 unembalmed cadaveric whole lower limbs. Motion was measured with a six degrees-of-freedom electrogoniometer. The lateral structures investigated were the iliotibial band and mid-lateral capsule, lateral collateral ligament, and popliteus tendon and the posterolateral capsule. Cutting the anterolateral structures increased anterior translation and internal rotation, particularly in flexion. Increases in motions were highly variable, reflecting the variation in function in the lateral collateral ligament and posterolateral structures. Cutting the lateral collateral ligament produced small changes in anterior translation and external rotation and larger increases in adduction. Cutting the posterolateral structures produced small increases in external rotation. Large increases in external rotation were found only if the lateral collateral ligament was also sectioned. The posterolateral structures act in concert with the lateral collateral ligament in restraining internal and external rotation. External rotation was affected at all flexion angles; internal rotation was affected mainly in extension. Our results can be used in the diagnosis of complex knee ligament injuries. Findings of increased anterior translation in both flexion and extension and increased internal rotation at 90 degrees of flexion are consistent with combined injury to the anterior cruciate ligament and the anterolateral structures. The anterior cruciate ligament-deficient knee with significant posterolateral compromise (posterolateral structures/lateral collateral ligament) would exhibit larger anterior translation in extension than in flexion, increased adduction, and increased external rotation in both flexion and extension.
The Addition of Organomagnesium Halides to Pseudocodeine Types. II. Preparation of Nuclear Alkylated Morphine Derivatives1 (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Addition of Organomagnesium Halides to Pseudocodeine Types. II. Preparation of Nuclear Alkylated Morphine Derivatives1Lyndon Small, Howard M. Fitch, and William E. SmithCite this: J. Am. Chem. Soc. 1936, 58, 8, 1457–1463Publication Date (Print):August 1, 1936Publication History Published online1 May 2002Published inissue 1 August 1936https://pubs.acs.org/doi/10.1021/ja01299a043https://doi.org/10.1021/ja01299a043research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Parallel architectures for vision (1988)

Options are examined that drive the design of a vision-oriented computer, beginning with the analysis of the basic vision computation and communication requirements. The classical taxonomy is briefly reviewed for parallel computers, based on the instruction and data stream. A recently proposed criterion, the degree of autonomy of each processor, is applied to further classify fine-grain SIMD (single-instruction, multiple-data-stream) massively parallel computers. Three types of processor autonomy, namely, operational autonomy, addressing autonomy, and connection autonomy, are identified. For each type, the basic definition is given and some examples shown. The concept of connection autonomy, which is believed to be the key point in the development of massively parallel architectures for vision, is presented. Two examples are shown of parallel computers featuring different types of connection autonomy-the Connection Machine and the polymorphic-Torus-and their cost and benefits are compared.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression (2007)

Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast neoplasm is largely determined by the type of immune response elicited. Acute tumor-directed immune responses involving cytolytic T lymphocytes appear to protect against tumor development, whereas immune responses involving chronic activation of humoral immunity, infiltration by Th2 cells, and protumor-polarized innate inflammatory cells result in the promotion of tumor development and disease progression. Herein we review this body of literature and summarize important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis.
Model Predictive Control for Automated Network Assurance in Intent-Based Networking enabled Service Function Chains (2023)

Recent trends in Network Function Virtualization (NFV) combined with Internet of Things (IoT) and 5G applications have reshaped the network service offering. In particular, Service Function Chains (SFCs) can associate network functions with physical and virtual resources towards providing a complete network service. Concurrently, the management of a continuously expanding network and the fulfillment of the applications’ requirements pave the way for autonomic network solutions. Intent Based Networking (IBN) is a novel paradigm that aims to achieve the automatic orchestration of network services and the assurance of their performance. Accordingly, in this paper, we propose a novel automated network assurance model, based on Model Predictive Control, to guarantee the Quality of Service (QoS) and security requirements of multi-tenant and IBN-enabled SFCs. In this context, corrective decisions are proactively taken, in the form of incoming intent relocations among the SFCs. The results reveal that our model can assure with high probability the application requirements and minimize QoS violations.
A 0.25mm<sup>3</sup> Atomic Force Microscope on-a-chip (2015)

This paper reports the highest resolution achieved with a single-chip Atomic Force Microscope (sc-AFM). Images of a 20nm AFM calibration standard were obtained to show, for the first time, that single-chip instruments may obtain a vertical resolution comparable to state-of-the-art instruments at a minuscule fraction of the size (volume=1/1,000,000) and cost (1/1000). A maskless, 2-step release process is performed on CMOS chips in order to obtain devices that can image a sample without the need for any off-chip scanning or sensing components. We report a four-fold improvement in resolution when compared to previously reported sc-AFMs, enabling metrology for nanoscale manufacturing using MEMS AFM technology.
Stretchable and Tunable Microtectonic ZnO-Based Sensors and Photonics (2015)

The concept of realizing electronic applications on elastically stretchable "skins" that conform to irregularly shaped surfaces is revolutionizing fundamental research into mechanics and materials that can enable high performance stretchable devices. The ability to operate electronic devices under various mechanically stressed states can provide a set of unique functionalities that are beyond the capabilities of conventional rigid electronics. Here, a distinctive microtectonic effect enabled oxygen-deficient, nanopatterned zinc oxide (ZnO) thin films on an elastomeric substrate are introduced to realize large area, stretchable, transparent, and ultraportable sensors. The unique surface structures are exploited to create stretchable gas and ultraviolet light sensors, where the functional oxide itself is stretchable, both of which outperform their rigid counterparts under room temperature conditions. Nanoscale ZnO features are embedded in an elastomeric matrix function as tunable diffraction gratings, capable of sensing displacements with nanometre accuracy. These devices and the microtectonic oxide thin film approach show promise in enabling functional, transparent, and wearable electronics.
Papermaking properties of the ECF-bleached kraft pulps from first-thinning Scots pine (Pinus sylvestris L.) (2007)

Abstract First-thinning Scots pine ( Pinus sylvestris ) and the outer (containing long fibers) and inner (containing short fibers) parts of its stem wood were delignified on a laboratory scale by kraft pulping followed by oxygen-alkali delignification and bleaching with D 0 (EO)D 1 (EP)D 2 . The aim was to evaluate the potential use of the bleached pulps as reinforcing material in various mechanical and chemical pulps. The physical and optical properties of the pulps indicated that only the “outer part pulp”, with rather similar properties to those of a reference softwood kraft pulp, seemed suitable for this purpose. In contrast, materials from first-thinning stem wood and its inner part resulted in lower yields as early as the kraft pulping stage. Rather mediocre strength properties were obtained, but the bleached kraft pulps prepared from the two first thinning-based materials had good optical properties.
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) (2018)

Chia seeds are gaining increasing interest among food producers and consumers because of their prohealth properties. The aim of this work was to evaluate the potential of chia seeds to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest inhibitory activity against AChE and BChE was observed for colored seed ethanol extracts. A positive correlation was found between the presence of quercetin and isoquercetin as well as protocatechuic, hydroxybenzoic, and coumaric acids and the activity of extracts as AChE and BChE inhibitors. It has also been shown that grain fragmentation affects the increase in the activity of seeds against cholinesterases (ChE). Furthermore, seeds have been shown to be a source of substances that inhibit microbial growth. It was found that the chia seed extracts are rich in polyphenols and inhibit the activity of ChEs; therefore, their use can be considered in further research in the field of treatment and prevention of neurodegenerative diseases. How to cite: Kobus-Cisowska J, Szymanowska D, Maciejewska P, et al. In vitro screening for acetylcholinesterase and butyrylcholinoesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica). Electron J Biotechnol 2019;37. https://doi.org/10.1016/j.ejbt.2018.10.002
Structural investigation of some molecular complexes, and their related compounds (1968)

The reduction of benzotrifuroxan(I) by triethyl phosphite gives a crystalline 1:1 molecular complex of benzotrifurazan(II) with triethyl phosphate ester. The structure of the complex (at -120°C.) was solved by X-ray crystallography and the molecules were found to be associated by a weak 'polar' interaction between the phosphoryl (P=0) bond of the phosphate and the molecular system of benzotrifurazan. The phosphoryl bond was almost coincident with the three-fold axis of the heterocycle. The reaction of triphenyl phosphine with benzotrifuroxan was very complex and the product contained a large number of coloured compounds but no benzotrifurazan. Five crystalline compounds were isolated in small yield: a red, a light green, a yellow, a darker green and traces of a blue compound. Analysis of the first four showed that they contained both nitrogen and phosphorus but the physical data for the compounds gave little further information. The structures of all five compounds have been solved by X-ray crystallography. The red compound is a molecular complex of an <em>aci</em>- nitro- benzo- difurazan, associated as an ion pair with protonated triphenyl phosphine oxide(III). There is also a close approach of the planes through two difurazan molecules and the red colour is thought to result from charge transfer between these two molecules. The light green compound is a triphenylphosphine-nitroso-benzo- difurazan and is best represented as (IV). The colour is attributed to the aromatic nitroso chromophore. The yellow compound is a <em>sym</em>-triphosphazine-trinitrobenzene and is represented as (V). The central C<sub>6</sub> ring is distorted from a regular hexagon by the nitro groups bonded to it, and the planes of these nitro groups are almost perpendicular to the planes of the central ring. The blue compound is an unusual diphosphorane (VI). The central C<sub>6</sub> rings are deformed into boat conformations without completely destroying the associated π system and the geometry of the compound is that expected for an overcrowded aromatic molecule. The structure of the dark green compound (VII) was determined by Miss J. M. Evans (Oxford University). The reaction mechanisms for the reduction of benzotrifuroxan by triphenyl phosphine and by trialkyl phosphites is discussed within the context of the general reactions of P(III) compounds, and possible methods are suggested for the formation of the red, light green and yellow compounds and for the phosphate ester complex.