gebhart/patrepeval huggingface dataset:
Simvastatin inactivates β1‐integrin and extracellular signal‐related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells (2007)

The 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, also called statins, are commonly used as lipid-lowering drugs that inhibit cholesterol biosynthesis. An anticancer effect, as a pleiotropic function of certain statins, has been hypothesized. In the present study, we investigated the effect of simvastatin, one of the natural statins, on cell proliferation, cell cycle, invasive activity, and molecular expressions associated with cell-extracellular matrix adhesion, signal transduction, and DNA synthesis in Tu167 and JMAR cells from head and neck squamous cell carcinoma. The addition of simvastatin resulted in a dose-dependent inhibition of cell growth and migration into the extracellular matrix. Considerable morphological changes occurred after treatment with simvastatin, demonstrating loss of cell adhesion and disruption of actin filaments in cytoplasm. The inhibitory effect of simvastatin on cell proliferation seemed to be associated with cell cycle arrest and increased expression of p21, p27, and activated caspase-3. The expression of beta1-integrin, a counter adhesion for the extracellular matrix, phosphorylated FAK, and phosphorylated ERK was decreased by treatment with simvastatin. The proapoptotic effect of simvastatin was inhibited by treatment with mevalonate. cDNA microarray assay demonstrated that molecular changes resulting from treatment with simvastatin included the up-regulation of cell cycle regulators and apoptosis-inducing factors and the down-regulation of integrin-associated molecules and cell proliferation markers. Of down-regulated genes induced by simvastatin treatment, a significant depletion of thymidylate synthase was confirmed using western blot analysis. These results imply that simvastatin has the potential to be effective for the prevention of the growth and metastasis of cancer cells.
The amino acid sequence of the light chain of human high-molecular-mass kiniogen (1985)

The complete amino acid sequence of the light chain of human high-molecular-mass kininogen has been determined. The peptide chain contains 255 amino acid residues. The half-cystine, which forms the disulfide bridge to the heavy chain, was identified in position 225. Nine carbohydrate attachment sites were found. All carbohydrate side chains are O-glycosidically linked. Alignment of the present sequence with the bovine kininogen light chain sequence shows a high degree of homology, except for an extension of 22 amino acids within the histidine-rich part of the sequence. The histidine-rich region may have arisen by gene multiplication during evolution.
The Role of Radiosurgery in the Management of Chordoma and Chondrosarcoma of the Cranial Base (1991)

Abstract Despite conventional multimodality treatment (surgery and fractionated radiation therapy), recurrence and clinical progression of cranial base chordomas and chondrosarcomas are common. The malignant behavior of these tumors is a result of their critical location, locally aggressive nature, and high recurrence rate. To explore the role of radiosurgery in the treatment of these skull base neoplasms, we assessed its use in four patients with chordoma and two with chondrosarcoma. In five of the patients, radiosurgery was used as adjuvant therapy for residual or recurrent tumors after surgical debulking, and in one patient with a chordoma, it was the primary treatment. No patient received fractionated external beam radiotherapy. All tumors were less than 30 mm in diameter and were treated with 20 Gy to the tumor margin. Skull base computed tomography and magnetic resonance images were essential to define the anatomic relationships between tumor and adjacent basal structures. During follow-up (mean, 22 mo; range, 8-36 mo), we found no progression of the treated tumor volume in any patient. Neurological deficits before treatment improved in three patients; the other three patients remained in stable neurological condition. Serial follow-up imaging studies demonstrated that two patients showed reduction in tumor size and four patients had no tumor growth. In one patient, a metastatic parietal lobe chondrosarcoma developed and was treated by microsurgery. Another patient showed tumor progression outside of the radiosurgical trcatment volume. Our results attest to the value of stereotactic radiosurgery as an adjuvant or primary treatment for selected patients with chordoma or chondrosarcoma and demonstrate its potential advantages over standard fractionated irradiation. Analysis of the long-term clinical and imaging effects after radiosurgery is warranted. (Neurosurgery 29:38-46, 1991)
ChemInform Abstract: FRAGMENTIERUNGS‐RK. 25. MITT. ZWEISTUFIGER CARBANION‐MECHANISMUS DER FRAGMENTIERUNG VON 3‐AMINO‐PROPYLBENZOATEN (1972)

Abstract Die Benzoate (Ib) fragmentieren bei 65°C in 80%igem Äthanol quantitativ, ohne wesentlichen Einfluß der Substituenten Zauf die Reaktionsgeschwindigkeit, was eine primäre Spaltung in das Immoniumion (II) (mit den Folgeprodukten Dimethylamin und Formaldehyd) und die Carbanionen (IIIb) beweist; letztere stabilisieren sich zum Äthylen (IV) und entsprechendem Benzoatanion.
BAFF Blockade Attenuates Inflammatory Responses and Intestinal Barrier Dysfunction in a Murine Endotoxemia Model (2020)

B cell-activating factor (BAFF) production is increased in septic patients. However, the specific role of BAFF in sepsis remains unknown. This study was designed to investigate the expression and function of BAFF in an experimental endotoxemia model and to identify the potential mechanisms. We established an endotoxemia mouse (6-8 weeks, 20-22 g) model by administering 30 mg/kg lipopolysaccharide (LPS). BAFF levels in the circulating system and organ tissues were measured 4 and 8 h after LPS injection. Survival rates in the endotoxemia mice were monitored for 72 h after BAFF blockade. The effects of BAFF blockade on systemic and local inflammation, organ injuries, and intestinal barrier function were also evaluated 4 h after LPS treatment. BAFF production was systemically and locally elevated after LPS challenge. BAFF blockade improved the survival rate, systemic inflammation, and multi-organ injuries. Moreover, BAFF blockade attenuated both intestinal inflammation and impaired intestinal permeability. BAFF blockade upregulated ZO-1 and occludin protein levels <i>via</i> the NF-κB/MLCK/MLC signaling pathway. These results suggested that BAFF blockade protects against lethal endotoxemia at least partially by alleviating inflammation, multi-organ injuries, and improving intestinal barrier function and provides a novel focus for further research on sepsis and experimental evidence for clinical therapy.
Role of cell cycle control in radiosensitization of mouse spermatogonial stem cells (2001)

The results indicate that p53-independent cell cycle regulation plays an important role in the radiosensitization of mouse spermatogonial stem cells.
Regulation of alignment of cyanobiphenyl liquid crystals by azobenzene molecular films (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegulation of alignment of cyanobiphenyl liquid crystals by azobenzene molecular filmsKoso Aoki, Takashi Tamaki, Takahiro Seki, Yuji Kawanishi, and Kunihiro IchimuraCite this: Langmuir 1992, 8, 3, 1014–1017Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/la00039a045https://doi.org/10.1021/la00039a045research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flower-like ZnO@MnCo2O4 nanosheet structures on nickel foam as novel electrode material for high-performance supercapacitors (2016)

The flower-like ZnO@MnCo<sub>2</sub>O<sub>4</sub> nanosheet electrode exhibited high specific capacitance than dandelion-like MnCo<sub>2</sub>O<sub>4</sub>.
1.5 Gbit/s transmission system using all optical wavelength convertor based on tunable two-electrode DFB laser (1991)

An optical wavelength convenor has been successfully operated up to 1.5Gbit/s. This wavelength conversion used a two-electrode DFB laser where an amplitude modulated (AM) input signal at 1.5171 μm was converted into a frequency modulated (FM) output signal at 1.5136 μm.
Growth and Optical Properties of Gold Nanoshells Prior to the Formation of a Continuous Metallic Layer (2009)

The growth and optical properties of incomplete gold layers on silica particles (229 nm) are studied using visible/near-infrared spectroscopy and transmission electron microscopy. The gold particles that eventually coalesce to form a continuous gold layer are found to have droplet-like shapes. The optical properties of these systems are different from those of complete gold nanoshells. Using the discrete dipole approximation, it is found that the plasmon modes of such systems should exhibit two bands: one from 500-600 nm ("high energy") and the other from 600-800 nm ("low energy"). The calculations show that, for increasing coating density of the droplet-like particles, the lower energy band (i) becomes stronger relative to the higher energy band and (ii) is red-shifted. Both of these trends are found in the spectra of the prepared particles. Furthermore, the observed plasmon bands fall within the limits established by the model.
Biological and Clinical Implications of Lymphocyte Hybridomas: Tumor Therapy with Monoclonal Antibodies (1983)

Monoclonal antibodies of defined specificity can be produced using hybridoma technology. New attempts are being made to explore the potential of antibody therapy for cancer. Preliminary studies show that problems such as antigenic modulation, circulating free antigen, effector cell shortage, and host anti-mouse immunoglobulin response must be overcome. Uses of monoclonal antibodies in cancer treatment include the administration of unconjugated antibodies or of antibodies coupled to drugs, toxins, or radioisotopes, and the use of monoclonal antibodies in vitro to eradicate residual malignant cells.
Retrospective analysis of etiologic agents associated with respiratory diseases in pigs. (2003)

Twenty-eight hundred and seventy-two cases of respiratory disease in pigs were analyzed for their etiologic agents. Two or more pathogens were detected from 88.2% of the cases, indicating that porcine reproductive and respiratory syndrome virus (PRRSV) or swine influenza virus (SIV) combined with other bacterial agents was a common cause for porcine respiratory diseases in the mid-western USA.
Classification of Human Cataractous Change by the American Cooperative Cataract Research Group Method (1984)

The American Cooperative Cataract Research Group (CCRG) has adopted a system of classifying cataractous changes in excised human cataracts that is based on separate and independent photographic documentation of opacification and nuclear colour. The classification data can be simplified according to the needs of the scientist in his or her effort to measure clinically or scientifically significant associations between laboratory measures and cataractous change. The association between nuclear colour and the extent of cortical opacification and the intensity of nuclear opacification has been studied and found to be insignificant. These results justify the recommendation that nuclear colour be abandoned as the single index of severity of any type of senile cataractous change. The adaptability of this system to in vivo use in epidemiological and other studies of the natural history of cataractous change is discussed. Its limitations are outlined. The system may offer a basis for international cooperation in cataract classification.
ChemInform Abstract: Structure of Dimetridazole at 293 K (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improved Thermo-Oxidative-Deposition Screening Tests for Turbine Lubricants (1989)

Abstract : This research applied combined Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques to establish a potential new laboratory screening method for simulating and differentiating the high temperature lubricant degradation phenomena of oils in operational turbine engines. (jg)
Simulated and Experimental Comparisons of Slip and Torque Control Strategies for Regenerative Braking in Instances of Parametric Uncertainties (2015)

&lt;div class=""abs_img""&gt; &lt;img src=""[disp_template_path]/JRM/abst-image/00270003/02.jpg"" width=""340"" /&gt; Slip efficiency map &amp; control law&lt;/div&gt; A three-wheel hybrid recreational vehicle was studied for the purpose of regenerative braking control. In order to optimize the amount of energy recovered from electrical braking, most of the existing literature presents optimal methods which consist in defining the optimal braking torque as a function of vehicle speed. The originality of the present study is to propose a new strategy based on the control of rear wheel slip. A simulator based on MATLAB/Simulink and validated with experimental measurements compared the two strategies and their sensitivities to variations in mass, slope and road conditions. Numerical simulations and experimental tests show that regenerative braking based on a slip controller was less affected by the majority of the parametric changes. Moreover, since the slip was limited, the longitudinal stability of the vehicle was thereby improved. It thus becomes possible to ensure optimal energy recovery and vehicle stability even in instances of parametric uncertainties.
Efficient Encapsulation of a Water‐Soluble Molecule into Lipid Vesicles Using W/O/W Multiple Emulsions via Solvent Evaporation (2016)

Abstract We developed a novel method for preparing lipid vesicles with high entrapment efficiency and controlled size using water‐in‐oil‐in‐water (W/O/W) multiple emulsions as vesicle templates. Preparation consists of three steps. First, a water‐in‐oil (W/O) emulsion containing to‐be‐entrapped hydrophilic molecules in the water phase and vesicle‐forming lipids in the oil phase was formulated by sonication. Second, this W/O emulsion was introduced into a microchannel emulsification device to prepare a W/O/W multiple emulsion. In this step, sodium caseinate was used as the external emulsifier. Finally, organic solvent in the oil phase was removed by simple evaporation under ambient conditions to afford lipid vesicles. The diameter of the prepared vesicles reflected the water droplet size of the primary W/O emulsions, indicating that vesicle size could be controlled by the primary W/O emulsification process. Furthermore, high entrapment yields for hydrophilic molecules (exceeding 80 % for calcein) were obtained. The resulting vesicles had a multilamellar vesicular structure, as confirmed by transmission electron microscopy.
Membrane-bound dehydrogenase from Serratia marcescens that catalyzes oxidation of maltose. (1986)

Many papers deal with oxidation-reduction enzymes in the metabolism of carbohydrates.
The effects of thyroxine on hair growth in the dog (1986)

ABSTRACT The effects of orally and topically administered thyroxine on hair growth were studied in normal, intact, cross‐bred male dogs maintained under the same controlled conditions of temperature and photoperiod. It was found that, irrespective of the route of administration, thyroxine produced an increase in both the rate of hair growth and in the number of hair follicles entering the anagen phase of the hair cycle. With orally administered thyroxine, the changes in hair growth were most marked in the flank region.
[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]. (1992)

The effect of topical 0.5% timolol on the permeability of the blood-aqueous barrier to plasma protein was studied in ten young normal volunteers. Before and after instillation of timolol in one eye, simultaneous measurements of aqueous flow rate, f(t), by fluorophotometry and protein concentration in the anterior chamber, Ca(t), with a laser flare-cell meter were made in both eyes at hourly intervals. The coefficient of protein entry into the anterior chamber was calculated using an equation formulating protein dynamics in the anterior chamber from the changes in f(t), Ca(t), and plasma protein concentration. The Ca(t) in the treated eye showed a maximum increase of 37 +/- 4% (mean +/- SEM) as compared with that in the fellow eye 5 hours after instillation, while the f(t) in the treated eye showed a maximum reduction of 30 +/- 4% 2 hours after instillation. The intraocular pressure in the treated eye showed a maximum reduction of 3.0 +/- 0.3 mmHg 2 hours after instillation. No significant changes were found in the coefficient of protein entry in the anterior chamber between before and after timolol instillation or between timolol-treated and fellow untreated eyes. These results indicated that topical 0.5% timolol does not affect the permeability of the blood-aqueous barrier to plasma protein significantly.
Consequences of Exchanging Carbohydrates for Proteins in the Cholesterol Metabolism of Mice Fed a High-fat Diet (2012)

Consumption of low-carbohydrate, high-protein, high-fat diets lead to rapid weight loss but the cardioprotective effects of these diets have been questioned. We examined the impact of high-protein and high-fat diets on cholesterol metabolism by comparing the plasma cholesterol and the expression of cholesterol biosynthesis genes in the liver of mice fed a high-fat (HF) diet that has a high (H) or a low (L) protein-to-carbohydrate (P/C) ratio. H-P/C-HF feeding, compared with L-P/C-HF feeding, decreased plasma total cholesterol and increased HDL cholesterol concentrations at 4-wk. Interestingly, the expression of genes involved in hepatic steroid biosynthesis responded to an increased dietary P/C ratio by first down-regulation (2-d) followed by later up-regulation at 4-wk, and the temporal gene expression patterns were connected to the putative activity of SREBF1 and 2. In contrast, Cyp7a1, the gene responsible for the conversion of cholesterol to bile acids, was consistently up-regulated in the H-P/C-HF liver regardless of feeding duration. Over expression of Cyp7a1 after 2-d and 4-wk H-P/C-HF feeding was connected to two unique sets of transcription regulators. At both time points, up-regulation of the Cyp7a1 gene could be explained by enhanced activations and reduced suppressions of multiple transcription regulators. In conclusion, we demonstrated that the hypocholesterolemic effect of H-P/C-HF feeding coincided with orchestrated changes of gene expressions in lipid metabolic pathways in the liver of mice. Based on these results, we hypothesize that the cholesterol lowering effect of high-protein feeding is associated with enhanced bile acid production but clinical validation is warranted. (246 words).
Data from EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Mutant selective irreversible pyrimidine-based EGFR kinase inhibitors, including WZ4002, CO-1686, and AZD9291, are effective in preclinical models and in lung cancer patients harboring the &lt;i&gt;EGFR&lt;/i&gt; T790M gefitinib/erlotinib resistance mutation. However, little is known about how cancers develop acquired resistance to this class of EGFR inhibitors. We sought to identify and study &lt;i&gt;EGFR&lt;/i&gt; mutations that confer resistance to this class of agents.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We performed an N-ethyl-N-nitrosourea (ENU) mutagenesis screen in &lt;i&gt;EGFR&lt;/i&gt;-mutant (sensitizing alone or with concurrent &lt;i&gt;EGFR&lt;/i&gt; T790M) Ba/F3 cells and selected drug-resistant clones. We evaluated the sensitivity of EGFR inhibitors in models harboring drug-resistant &lt;i&gt;EGFR&lt;/i&gt; mutations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We identified 3 major drug resistance mutations. &lt;i&gt;EGFR&lt;/i&gt; L718Q, L844V, and C797S cause resistance to both WZ4002 and CO-1686 while, in contrast, only &lt;i&gt;EGFR&lt;/i&gt; C797S leads to AZD9291 resistance. Cells containing an &lt;i&gt;EGFR&lt;/i&gt;-sensitizing mutation, Del 19 or L858R, in conjunction with L718Q, L844V, or C797S retain sensitivity to quinazoline-based EGFR inhibitors, gefitinib and afatinib. The C797S mutation, in the presence of Del 19 or L858R and T790M, causes resistance to all current EGFR inhibitors, but L858R/T790M/C797S remains partially sensitive to cetuximab which leads to disruption of EGFR dimerization.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings provide insights into resistance mechanisms to irreversible pyrimidine-based EGFR inhibitors and identify specific genomic contexts in which sensitivity is retained to existing clinical EGFR inhibitors. These findings will guide the development of new strategies to inhibit EGFR. &lt;i&gt;Clin Cancer Res; 21(17); 3913–23. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Ayeni et al., p. 3818&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Placement of traffic barriers on roadside and median slopes – guidelines based on numerical simulations (2013)

This paper presents the results of numerical studies performed to evaluate the performance of four commonly used traffic barriers on roadside and median slopes. The selected guardrail/barrier systems are the modified G4(1S) W-beam guardrail, modified thrie-beam guardrail, Midwest guardrail system and modified weak-post W-beam guardrail. For barriers placed on slopes, vehicle impact height varies depending on the trajectory of the vehicle along the ditch section and lateral offset of the barrier. Multi-rigid-body dynamic analysis code, CARSIM, is used to identify trajectories of the vehicles traversing various roadside and median cross-slopes. Performance limits of each barrier in terms of acceptable vehicle impact heights are superimposed on the trajectory data to identify safe lateral offset locations for each barrier. The resulting placement guidelines are then refined using the responses obtained from LS-DYNA simulations that capture the full encroachment event from departure of the vehicle off the travelled way through impact with the barrier.
Safety of [177Lu]Lu-NeoB treatment: a preclinical study characterizing absorbed dose and acute, early, and late organ toxicity (2022)

In general, repeated administration of [<sup>177</sup>Lu]Lu-NeoB was tolerated. The most significant radiotoxic effects were found in the kidneys, similar to other clinically applied radioligands. The results of this study underline the potential of [<sup>177</sup>Lu]Lu-NeoB as a promising option for clinical therapy.