gebhart/patrepeval huggingface dataset:
[Facing COVID-19 : myocarditis following vaccination with mRNA SARS-CoV-2]. (2023)

Myocarditis is a relatively uncommon and underdiagnosed heart disease. Its clinical presentation is variable, from pauci-symptomatic to a symptomatology of sudden chest pain. The latter mimics cardiological emergencies and must therefore be quickly discerned to guide the rest of the treatment. The treatment is mainly supportive and rarely directly etiological. This is a pathology that resurfaced with the onset of the COVID-19 pandemic but also with vaccination. We present here the case of a mRNA SARS-CoV-2 vaccine-induced myocarditis whose clinical manifestations impose a rapid decision concerning the differential diagnosis with an acute coronary syndrome.
Common-Centroid Layout for Active and Passive Devices: A Review and the Road Ahead (2022)

This paper presents an overview of common-centroid (CC) layout styles, used in analog designs to overcome the impact of systematic variations. CC layouts must be carefully engineered to minimize the impact of mismatch. Algorithms for CC layout must be aware of routing parasitics, layout-dependent effects (for active devices), and the performance impact of layout choices. The optimal CC layout further depends on factors such as the choice of the unit device and the relative impact of uncorrelated and systematic variations. The paper also examines scenarios where non-CC layouts may be preferable to CC layouts.
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation (2003)

Plasma cells (PCs), the end point of B-cell differentiation, are a heterogeneous cell compartment comprising several cell subsets from short-lived highly proliferative plasmablasts to long-lived nondividing fully mature PCs. Whereas the major transcription factors driving the differentiation of B cells to PCs were recently identified, the subtle genetic changes that underlie the transition from plasmablasts to mature PCs are poorly understood. We recently described an in vitro model making it possible to obtain a large number of cells with the morphologic, phenotypic, and functional characteristics of normal polyclonal plasmablastic cells (PPCs). Using Affymetrix microarrays we compared the gene expression profiles of these PPCs with those of mature PCs isolated from tonsils (TPCs) and bone marrow (BMPCs), and with those of B cells purified from peripheral blood (PBB cells) and tonsils (TBCs). Unsupervised principal component analysis clearly distinguished the 5 cell populations on the basis of their differentiation and proliferation status. Detailed statistical analysis allowed the identification of 85 PC genes and 40 B-cell genes, overexpressed, respectively, in the 3 PC subsets or in the 2 B-cell subsets. In addition, several signaling molecules and antiapoptotic proteins were found to be induced in BMPCs compared with PPCs and could be involved in the accumulation and prolonged survival of BMPCs in close contact with specialized stromal microenvironment. These data should help to better understand the molecular events that regulate commitment to a PC fate, mediate PC maintenance in survival niches, and could facilitate PC immortalization in plasma cell dyscrasias.
Stepwise syntheses of mono- and di-nuclear ruthenium tpphz complexes [(bpy)2Ru(tpphz)]2–and [(bpy)2Ru(tpphz)Ru(bpy)2]4+{tpphz = tetrapyrido[3,2-a: 2′,3′-c: 3″,2″-h: 2″,3‴-j]phenazine} (1995)

The complex [(bpy)2Ru(tpphz)]2+(tpphz = tetrapyridophenazine), is obtained by reaction of [(bpy)2Ru(phendione)]2+with 5,6-diamino-1,10-phenanthroline; upon reaction with [(bpy)2Ru(Me2CO)2]2+, the fully conjugated dimer [(bpy)2Ru(tpphz)Ru(bpy)2]4+ is obtained.
Stability of indole-3-acetic acid to autoclaving, aeration and light illumination. (1979)

Indole-3-acetic acid (IAA) is well-known as natural auxin and used as a plant growth regulator in plant tissue culture.It is often said that IAA is unstable and easily decomposed by physical reactions, for example, light illumination or autoclaving, and also by chemical
DL-Willardiine mustard (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDL-Willardiine mustardAbelardo P. Martinez, William Wei Lee, and Leon GoodmanCite this: J. Med. Chem. 1968, 11, 1, 60–62Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a012https://doi.org/10.1021/jm00307a012research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction (2014)

Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy.
Tunable CW lasing around 610, 635, 695, 715, 885 and 910 nm in praseodymium-doped fluorozirconate fibre (1991)

CW lasing operation of a praseodymium-doped fluorozirconate fibre laser at 610, 635, 695, 715, 885 and 910 nm is reported, together with large tunability domains around these wavelengths. Output powers in excess of 20 mW at 610 nm, 50 mW at 715 nm and 100 mW at 635 nm, with a photon efficiency larger than 50%, have been obtained.
Secure query processing in intelligent database management systems (2003)

In a multilevel secure database management system, users cleared at different security levels access and share a database with data at different sensitivity levels. A serious threat to database security, not adequately addressed at present, is the inference problem. That is users acquire unauthorized information from the responses that they legitimately receive. It is the inferencing capability and deductive power of intelligent database systems that could provide viable approaches for handling the inference problem. The author describes secure query processing in intelligent database systems. The types of database systems that are considered are augmented relational systems, fuzzy relational systems and object-oriented systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Repellent function of male pheromones in the red&hyphen;spotted newt (2001)

Pheromones act as attractants and sexual stimulants in most vertebrates. For example, in red-spotted newts, Notophthalmus viridescens, female pheromones attract males, and male pheromones increase female receptivity. However, no studies have determined whether male vertebrates produce a pheromone that repels competing males. Through a series of olfactory mate selection tests, we found that sexually motivated male red-spotted newts produce a pheromone that functions to repel other approaching males. Our finding is the first report of a repelling function for pheromones in male vertebrates. The pheromones may act to increase both the sender's and receiver's mating success when the operational sex ratio (OSR) is male biased.
Towards Multi-Layered 3D Garments Animation (2023)

Mimicking realistic dynamics in 3D garment animations is a challenging task due to the complex nature of multi-layered garments and the variety of outer forces involved. Existing approaches mostly focus on single-layered garments driven by only human bodies and struggle to handle general scenarios. In this paper, we propose a novel data-driven method, called LayersNet, to model garment-level animations as particle-wise interactions in a micro physics system. We improve simulation efficiency by representing garments as patch-level particles in a two-level structural hierarchy. Moreover, we introduce a novel Rotation Equivalent Transformation that leverages the rotation invariance and additivity of physics systems to better model outer forces. To verify the effectiveness of our approach and bridge the gap between experimental environments and real-world scenarios, we introduce a new challenging dataset, D-LAYERS, containing 700K frames of dynamics of 4,900 different combinations of multi-layered garments driven by both human bodies and randomly sampled wind. Our experiments show that LayersNet achieves superior performance both quantitatively and qualitatively. We will make the dataset and code publicly available at https://mmlab-ntu.github.io/project/layersnet/index.html .
Brassica juncea Produces a Phytochelatin-Cadmium-Sulfide Complex (1992)

Phytochelatins (PCs) are enzymically synthesized peptides produced in higher plants and some fungi upon exposure to heavy metals. We have examined PC production in the Se-tolerant wild mustard Brassica juncea and found that it produces two types of PC-Cd complexes with the same characteristics as those from fission yeast Schizosaccharomyces pombe, including a high molecular weight PC-Cd-sulfide form.
Development of a dual‐color, double fusion FISH assay to detect RPN1/EVI1 gene fusion associated with inv(3), t(3;3), and ins(3;3) in patients with myelodysplasia and acute myeloid leukemia (2010)

Approximately 2-3% of adult patients with acute myeloid leukemia harbor a rearrangement of RPN1 (at 3q21) and EVI1 (at 3q26.2) as inv(3)(q21q26.2), t(3;3)(q21;q26.2), or ins(3;3)(q26.2;q21q26.2). The most recent World Health Organization (WHO) classification has designated AML with inv(3) or t(3;3) and associated RPN1/EVI1 fusion, as a distinct AML subgroup associated with an unfavorable prognosis. We have created a dual color, double fusion fluorescence in situ hybridization (D-FISH) assay to detect fusion of the RPN1 and EVI1 genes. A blinded investigation was performed using 30 normal bone marrow samples and 51 bone marrow samples from 17 patients with inv(3)(q21q26.2), 11 patients with t(3;3)(q21;q26.2), and one patient with ins(3;3)(q26.2;q21q26.2) previously defined by chromosome analysis. The unblinded results indicated abnormal RPN1/EVI1 fusion results in 30 (97%) of 31 samples from the inv(3)(q21q26.2) group including seven bone marrow samples for which chromosome analysis was unsuccessful or failed to detect an inv(3)(q21q26.2). Abnormal FISH results were detected in 14 (88%) of 16 samples with t(3;3)(q21;q26.2) and in the sole sample with an ins(3;3)(q26.2;q21q26.2). All 30 negative controls were normal and were used to establish a normal cutoff of 0.6% for the typical abnormal D-FISH signal pattern. Overall, this D-FISH assay was more accurate than chromosome analysis and based on the normal cutoff of 0.6%, this assay can be used for minimal residual disease detection and disease monitoring in patients with RPN1/EVI1 fusion.
Effect of Sample-loading on Fractionation Efficiency (FE) in a Large Scale Splitter-less Gravitational SPLITT Fractionation (GSF) (2011)

Gravitational SPLITT fractionation (GSF) provides separation of colloidal particles into two subpopulations in a preparative scale. Conventionally, GSF is carried out in a thin rectangular channel having two inlets and two outlets at the top and bottom of the channel, respectively. And the channel is equipped with two flow-splitters, one between the top and bottom inlets and another between the top and bottom outlets. A large scale splitter-less GSF system had been developed, which was designed to operate in the full feed depletion (FFD) mode. In the FFD mode, there is only one inlet through which the sample is fed, thus preventing the sample dilution. In this study, the effect of the sample-loading (in the unit of g/hr) on the fractionation efficiency (FE, number% of particles in a GSF fraction that have the sizes expected by theory) of the new large scale splitter-less FFD-GSF system was investigated. The system was tested in the sample-loading range of 3.0-12.0 g/hr with polyurethane latex beads (PU) and sea-sediment. It was found that there is an optimum range in the sample-loading for a FFD-GSF separation. It was also found that there is a general tendency of FE decreasing as the concentration of the sample suspension increases.
Differential Effects of ChlorthalidoneVersusSpironolactone on Muscle Sympathetic Nerve Activity in Hypertensive Patients (2009)

Our data suggest that chlorthalidone, the first-line drug therapy for hypertension, causes persistent activation of sympathetic nervous system and insulin resistance in hypertensive patients. These side effects, however, are avoided by spironolactone despite similar reduction in BP.
Spherical microphone array beampattern design for improved room acoustics analysis (2008)

Spherical microphone arrays have been recently studied for sound-field analysis in auditoria. Beamforning was employed for spatial separation of individual reflections from the stage to the seating area, therefore providing detailed spatial mapping of sound propagation. In this work beampattern design for spherical microphone arrays is employed to achieve improved analysis of the sound field. Spatial �spectral� temporal trade-offs in the sound-field analysis will be discussed. Finally, experimental results from auditorium measurements will be presented.
Investigating the SPECT Dose-Function Metrics Associated With Radiation-Induced Lung Toxicity Risk in Patients With Non-small Cell Lung Cancer Undergoing Radiation Therapy (2021)

Irradiation of the inferior lung appears to be a locational sensitivity for RILT risk. The multivariable correlation between ipsilateral lung iV<sub>20</sub> and RILT, as well as the association of low-functioning V/Q<sub>20</sub> and RILT, suggest that irradiating low-functioning regions in the lung may lead to higher toxicity rates.
Supplementary Figure 6 from Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes (2023)

&lt;p&gt;G007-LK-treatment in different CRC cell lines.&lt;/p&gt;
Robust Interaction Control of a Dielectric Elastomer Actuator With Variable Stiffness (2017)

This paper presents an interaction control algorithm for a dielectric elastomer membrane actuator. The proposed method permits efficient exploitation of the controllable stiffness of the material, allowing to use the membrane as a “programmable spring” in applications such as robotic manipulation or haptic devices. To achieve this goal, we propose a design algorithm based on robust control theory and linear matrix inequalities. The resulting controller permits to arbitrarily shape the stiffness of the elastomer, while providing robust stability and performance with respect to model nonlinearities. A self-sensing displacement estimation algorithm allows implementation of the method without the need of a deformation sensor, thus reducing cost and size of the system. The approach is validated on an experimental prototype consisting of an elastomer membrane preloaded with a bistable biasing spring.
Malnutrition and immune cell subsets in children undergoing kidney transplantation (2022)

Children with obesity have distinct immunophenotypes that may influence the tailoring of immunosuppression.
Expression of amino acid transporter LAT1 and 4F2hc in the healing process after the implantation of a tooth ash and plaster of Paris mixture. (2007)

These results suggest that the LAT1 and its subunit 4F2hc are highly expressed in the early stage of new bone formation and may have an important role in providing cells with neutral amino acids, including several essential amino acids, at that stage.
Supplementary Figures 1 through 17 and Supplementary Tables 1 and 2 from Activating Mutations in <i>PIK3CB</i> Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β (2023)

&lt;p&gt;Supplementary Figure S1. Inhibition of AKT and S6 phosphorylation. Supplementary Figure S2. Cell growth inhibition by a panel of compounds. Supplementary Figure S3. Effect of GDC-0980 on AKT and S6 phosphorylation. Supplementary Figure S4. Cell growth inhibition by a panel of compounds. Supplementary Figure S5. Inhibition of AKT phosphorylation. Supplementary Figure S6. Cell growth inhibition by a panel of anti-cancer agents. Supplementary Figure S7. The alignment of C-terminus of Human p110 family. Supplementary Figure S8. Droplet digital PCR (ddPCR) detection of PIK3CB D1067Y mutation. Supplementary Figure S9. Detection of copy number variation. Supplementary Figure S10. A. Cell growth inhibition by GDC-0941. B. Droplet digital PCR (ddPCR) analysis of PTEN-null GDC-0941 resistant cell lines. Supplementary Figure S11. Droplet digital PCR detection of PIK3CB D1067V mutation. Supplementary Figure S12. PIK3CB mutant expressing EVSA-T cells are less sensitive to PI3K inhibitors. Supplementary Figure S13. Inhibition of AKT and S6 phosphorylation. Supplementary Figure S14. p110β dependency of A498. Supplementary Figure S15. ATP competition assay. Supplementary Figure S16. Relative quantification of baseline AKT phosphorylation levels in EVSA-T parental cells and resistant clones. Supplementary Figure S17. Signal profile in Rat-2 stable cell lines. Supplementary Table S1 Compound list. Supplementary Table S2 Whole exome sequencing list of genes mutated in EVSA-T GDC-0941 resistant cells.&lt;/p&gt;
A case of membranoproliferative glomerulonephritis accompanied with hyper IgM immunodeficiency. (1985)

高IgM血症を伴う免疫不全症に膜性増殖性糸球体腎炎を合併した1症例を報告する.症例は41才,女性で,ネフローゼ症候群の精査目的にて昭和58年7月5日当科に入院.既往歴として幼少時より重篤な感染症あり.入院時,血清IgG 30mg/dl, IgA 10mg/dlと著減,一方IgMは2052mg/dlと著増していた.免疫電気泳動でpolyclonalな高IgM血症,骨髓像で形質細胞増加がみられない,末梢リンパ球のIgG, IgA産生能低下,細胞性免疫能は正常である事より,高IgM血症を伴う免疫不全症と診断した.さらに,腎生検にて膜性増殖性糸球体腎炎type Iの診断をえた.本症例の腎障害の発症には,血中IgM型immune complex高値である事より, IgM抗体によねimmune complex腎炎が推測された.
Development of an advanced, automatic, ultrasonic NDE imaging system via adaptive learning network signal processing techniques (1981)

Abstract : A conventional pulse-echo imaging system has been modified to operate with a linear ultrasonic array and associated digital electronics to collect data from a series of defects fabricated in aircraft quality steel blocks. A thorough analysis of the defect responses recorded with this modified system has shown that considerable improvements over conventional imaging approaches can be obtained in the crucial areas of defect detection and characterization. A combination of advanced signal processing concepts with the Adaptive Learning Network (ALN) methodology forms the basis for these improvements. Use of established signal processing algorithms such as temporal and spatial beam- forming in concert with a sophisticated detector has provided a reliable defect detection scheme which can be implemented in a microprocessor-based system to operate in an automatic mode. It is shown that signal features extracted from the detected responses contain diagnostic information which enables the defect to be characterized as to type, orientation, and size. Direct comparisons are made between conventional defect images and results obtained from this study; these demonstrate the improvements obtained with the new approach.
Multi-sensor fusion: a perspective (2002)

A survey of the state of the art in multisensor fusion is presented. Papers related to fusion have been surveyed and classified into six categories: scene segmentation, representation, 3-D shape, sensor modeling, autonomous robots, and object recognition. A number of fusion strategies have been employed to combine sensor outputs. These strategies range from simple set intersection, logical and operations, and heuristic production rules to more complex methods involving nonlinear least-squares fits and maximum-likelihood estimates. Sensor uncertainty has been modeled using Bayesian probabilities and support and plausibility involving the Dempster-Shafer formalism.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other? (2012)

The concordance between SPT and sIgE is surprisingly low for cow's milk and hen's egg on an individual basis. Therefore, the tests should not be used interchangeably. Especially in children who receive a negative test result the alternative test should also be used. Furthermore, our data indicate again that oral food challenges are still the method of choice to diagnose food allergies.
Effective Killing of Acute Myeloid Leukemia by TIM-3 Targeted Chimeric Antigen Receptor T Cells (2021)

Acute myeloid leukemia (AML) is an aggressive disease with poor outcomes, overwhelmingly due to relapse. Minimal residual disease (MRD), defined as the persistence of leukemic cells after chemotherapy treatment, is thought to be the major cause of relapse. The origins of relapse in AML have been traced to rare therapy-resistant leukemic stem cells (LSCs) that are already present at diagnosis. Effective treatment strategies for long-term remission are lacking, as it has been difficult to eliminate LSCs with conventional therapy. Here, we proposed a new approach based on the chimeric antigen receptor (CAR)-directed T lymphocytes, targeting T-cell immunoglobulin, and mucin domain 3 (TIM-3) to treat MRD in patients with AML. TIM-3 is selected as the target because it is highly expressed on AML blasts and LSCs in most subtypes regardless of the patient's genetic characteristics and treatment course. Moreover, it is absent in the normal hematopoietic stem cells, granulocytes, naïve lymphocytes, and most normal nonhematopoietic tissues. Using a naïve human Fab phage display library, we isolated an anti-human TIM-3 antibody and designed a second-generation anti-TIM-3. Our anti-TIM-3 CAR T cells exhibit potent antileukemic activity against AML cell lines and primary AML blasts, and in the mouse models. More importantly, we demonstrate efficient killing of the primary LSCs directly isolated from the patients. Hence, eradication of the LSCs present in the MRD by anti-TIM-3 CAR T-cell therapy following the first-line treatment may improve the clinical outcomes of patients with AML.