gebhart/patrepeval huggingface dataset:
Abstract 5411: Efficient development of prognostic tests for detecting cancer risk using proteomic technology (2023)

Abstract Background: Prognostic models for assessing future health outcomes can be developed using time-to-event (also known as “survival”) data. This methodology is ubiquitous in statistical literature and in the analysis of cancer outcomes, but its use in high-dimensional analyses tends to be limited as the methods are difficult to implement in a machine learning environment. Additionally, development of certified prognostic clinical tests using proteomic biomarkers for detecting future cancer risk can be time-consuming, prone to overfitting issues, and difficult to navigate. We demonstrate the utility of combining SomaScan® proteomic data with pipeline machine learning tools and survival analysis methodology to identify powerful and robust LDT-certifiable prognostic tests for assessing future risk of cancer. Methods: Data pipeline and analysis tools were developed using R. In addition to standard machine learning techniques, statistical methods include elastic net AFT models, subsampling survival techniques, and metrics for assessing predictive survival models. The pipeline takes the analyst from data processing and QC through identification of optimal models for prediction of clinical endpoints, and then through validation on a hold-out test set. The tools include an assessment of model robustness against sample handling issues, longitudinal stability, the impacts of assay noise on model performance, effects of putative interferents, and risk of failure during CLIA validation in the lab. We demonstrate the utility of the tools and methods for development of a lung cancer risk model. Results: Analysis time for validation of an optimal clinical model was reduced by at least 80%, resulting in the development of 7 LDT-certified tests within 3 years, including a test for lung cancer risk. Inclusion of methods that allow for subsampling and penalized regression using AFT models show improved predictive performance and identification of top features related to clinical endpoints. Conclusion: Not only are powerful, prognostic tests do-able, but they can be LDT certified in an efficient manner and made to be robust to real-life lab settings. Survival analysis in a machine-learning setting allow us to leverage proteomic technology in new ways, leading to tests that assess future cancer risk, which can be used for precision medicine applications. Citation Format: Yolanda Hagar, Leigh Alexander, Jessica Chadwick, Gargi Datta, Joe Gogain, Rachel Ostroff, Clare Paterson, Laura Sampson, Caleb Scheidel, Sama Shrestha, Amy Zhang, Michael Hinterberg. Efficient development of prognostic tests for detecting cancer risk using proteomic technology. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5411.
Influence of atmospheric turbulence on the propagation of quantum states of light using plane-wave encoding (2011)

We consider the possibility of performing quantum key distribution (QKD) by encoding information onto individual photons using plane-wave basis states. We compare the results of this calculation to those obtained by earlier workers, who considered encoding using OAM-carrying vortex modes of the field. We find theoretically that plane-wave encoding is less strongly influenced by atmospheric turbulence than is OAM encoding, with potentially important implications for free-space quantum key distribution.
Influence of the Hand on the Specific Absorption Rate in the Head (2011)

The influence of the user's hand holding a mobile phone to the ear on the peak spatial-average Specific Absorption Rate (psSAR) averaged over any 1 g and 10 g of tissue in the head is investigated. This study is motivated by recent reports that found substantial increases in psSAR by the presence of the hand in some cases. Current measurement standards prescribe the measurement of SAR in a head phantom without a hand present. The mechanisms of interaction between the hand and mobile phone models are studied. Simulations and measurements at 900 and 1800 MHz have been conducted to complement the understanding of the hand grip parameters leading to higher SAR in the head. Numerical simulations were conducted on four mobile phone models, and parameters such as the palm-phone distance and hand position were varied. Measurements of 46 commercial mobile phones were made, and the maximum psSAR with different hand positions and palm-phone distances was recorded. Both simulations and measurements have found increases in the psSAR in the head of at least 2.5 dB due to the presence of the hand. Furthermore, the psSAR is sensitive to the hand grip, i.e., the variations can exceed 3 dB.
MyHealthAssistant: An Event-driven Middleware for Multiple Medical Applications on a Smartphone-Mediated Body Sensor Network (2014)

An ever-growing range of wireless sensors for medical monitoring has shown that there is significant interest in monitoring patients in their everyday surroundings. It however remains a challenge to merge information from several wireless sensors and applications are commonly built from scratch. This paper presents a middleware targeted for medical applications on smartphone-like platforms that relies on an event-based design to enable flexible coupling with changing sets of wireless sensor units, while posing only a minor overhead on the resources and battery capacity of the interconnected devices. We illustrate the requirements for such middleware with three different healthcare applications that were deployed with our middleware solution, and characterize the performance with energy consumption, overhead caused for the smartphone, and processing time under real-world circumstances. Results show that with sensing-intensive applications, our solution only minimally impacts the phone's resources, with an added CPU utilization of 3% and a memory usage under 7 MB. Furthermore, for a minimum message delivery ratio of 99.9%, up to 12 sensor readings per second are guaranteed to be handled, regardless of the number of applications using our middleware.
Disjointness of Stabilizer Codes and Limitations on Fault-Tolerant Logical Gates (2018)

Stabilizer codes are among the most successful quantum error-correcting codes, yet they have important limitations on their ability to fault tolerantly compute. Here, we introduce a new quantity, the disjointness of the stabilizer code, which, roughly speaking, is the number of mostly nonoverlapping representations of any given nontrivial logical Pauli operator. The notion of disjointness proves useful in limiting transversal gates on any error-detecting stabilizer code to a finite level of the Clifford hierarchy. For code families, we can similarly restrict logical operators implemented by constant-depth circuits. For instance, we show that it is impossible, with a constant-depth but possibly geometrically nonlocal circuit, to implement a logical non-Clifford gate on the standard two-dimensional surface code. Subject Areas: Quantum Physics, Quantum Information
Purification and some properties of two aminopeptidases from sardines. (1983)

Two fish aminopeptidases designated as aminopeptidases I and II were purified by DEAE-cellulose chromatography, gel filtration on Sephadex G-200, and isoelectric focusing. The final preparations of enzymes I and II were judged nearly homogenous by polyacrylamide gel electrophoresis. The molecular weights of enzymes I and II were determined by gel filtration to be 370, 000 and 320, 000, respectively. The isoelectric points were 4. 1 (I) and 4.8 (II). Both enzymes were inhibited by EDTA and activated by Co++. Bestatin could inhibit enzyme I but not enzyme II. Enzymes I and II rapidly hydrolyzed not only synthetic substrates containing alanine or leucine but also di-, tri-, and tetra-alanine. Judged from all of these properties, sardine aminopeptidases resemble human alanine aminopeptidase. Enzyme I retained more than 70% of its original activity in 15% NaCl, suggesting the enzyme participates in hydrolyzing fish proteins and peptides during fish sauce production.
Morphological characterization of the human corneal epithelium by in vivo confocal laser scanning microscopy (2021)

This <i>in vivo</i> study demonstrates the successful implementation of a CLSM-based imaging pipeline for cellular characterization of the human corneal epithelium. The dedicated hardware in combination with an adapted image registration method to correct the remaining motion-induced image distortions followed by a dedicated algorithm to calculate characteristic quantities of different epithelial cell layers enabled the generation of normative data. Further significant effort is necessary to improve the algorithm for superficial and basal cell segmentation.
Investigating the Problems of Ship Propulsion on a Supercomputer (2017)

Simulation of the water flow around a ship hull and a marine propeller operation are considered in this paper as popular problems of ship propulsion, which are frequently investigated through CFD approach now. CFD technologies are used for determination of ship hull resistance as well as the open water curves of the propeller according to usual methods of ship design. FlowVision CFD software is used for simulations based on solving RANS equations. The software was used together with supercomputer “HPC 2” of National Research Center “Kurchatov Institute”. The original features of the numerical models and technologies, software algorithms and the supercomputer's hardware are submitted and discussed. There are the method of grid formation based on Cartesian initial grid and chimerical overlapping boundary layer grid, special versions of turbulence models, modified method of free surface simulation and many other things among them. Governing equations for water flow, which are integrated using an implicit numerical method, are given as well. The generated systems of linear equations are solved by an aggregative algebraic multigrid method. The scalability of this method on the supercomputer has been studied and analyzed.
A galectin‐3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells (2011)

The results of the current study indicate that the naturally occurring Pro64His mutation in galectin-3 increases sensitivity to death receptor-mediated apoptosis. This finding could be relevant to disparities in breast cancer outcomes across population groups, and could guide the design of future clinical trials of TRAIL-based therapies.
Violent Passions, Hideous Deeds: A Review of Rodogune (1977)

Other| May 01 1977 Violent Passions, Hideous Deeds: A Review of Rodogune Rodogune, Pierre Corneille, Performed by the Theatre Oblique, American Place Theatre Gautam Dasgupta Gautam Dasgupta Search for other works by this author on: This Site Google Theater (1977) 8 (2_and_3): 164–166. https://doi.org/10.1215/00440167-8-2_and_3-164 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Gautam Dasgupta; Violent Passions, Hideous Deeds: A Review of Rodogune. Theater 1 May 1977; 8 (2_and_3): 164–166. doi: https://doi.org/10.1215/00440167-8-2_and_3-164 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsTheater Search Advanced Search The text of this article is only available as a PDF. Copyright © Yale/Theatre 19771977 Article PDF first page preview Close Modal You do not currently have access to this content.
Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration (2014)

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.
The place of vocabulary in language assessment (2000)

At first glance, it may seem that assessing the vocabulary knowledge of second language learners is both necessary and reasonably straightforward. It is necessary in the sense that words are the basic building blocks of language, the units of meaning from which larger structures such as sentences, paragraphs and whole texts are formed. For native speakers, although the most rapid growth occurs in childhood, vocabulary knowledge continues to develop naturally in adult life in response to new experiences, inventions, concepts, social trends and opportunities for learning. For learners, on the other hand, acquisition of vocabulary is typically a more conscious and demanding process. Even at an advanced level, learners are aware of limitations in their knowledge of second language (or L2) words. They experience lexical gaps, that is words they read which they simply do not understand, or concepts that they cannot express as adequately as they could in their first language (or L1). Many learners see second language acquisition as essentially a matter of learning vocabulary, so they devote a great deal of time to memorising lists of L2 words and rely on their bilingual dictionary as a basic communicative resource. Moreover, after a lengthy period of being preoccupied with the development of grammatical competence, language teachers and applied linguistic researchers now generally recognise the importance of vocabulary learning and are exploring ways of promoting it more effectively.
ACOs—Promise, Not Panacea (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A methodology for incorporating a photon‐counting CT system into routine clinical use (2023)

Photon-counting computed tomography (PCCT) systems are increasingly available in the U.S. following Food and Drug Administration (FDA) approval of the first clinical PCCT system in Fall 2021. Consequently, there will be a need to incorporate PCCTs into existing fleets of traditional CT systems. The commissioning process of a PCCT was devised by evaluating the degree of agreement between the performance of the PCCT and that of established clinical CT systems. A PCCT system (Siemens NAEOTOM Alpha) was evaluated using the American College of Radiology(ACR) CT phantom (Gammex 464). The phantom was scanned on the system and on a 3rd Generation EID CT system (Siemens Force) at three clinical dose levels. Images were reconstructed across the range of available reconstruction kernels and Iterative Reconstruction (IR) strengths. Two image quality metrics-spatial resolution and noise texture-were calculated using AAPM TG233 software (imQuest), as well as a dose metric to achieve target image noise magnitude of 10 HU. For each pair of EID-PCCT kernel/IR strengths, the difference in metrics were calculated, weighted, and multiplied over all metrics to determine the concordance between systems. IR performance was characterized by comparing relative noise texture and reference dose as a function of IR strength for each system. In general, as kernel "sharpness" increased for each system, spatial resolution, noise spatial frequency, and reference dose increased. For a given kernel, EID reconstruction showed higher spatial resolution compared to PCCT in standard resolution mode. PCCT implementation of IR better preserved noise texture across all strengths compared to the EID, demonstrated by respective 20 and 7% shifts in noise texture from IR "Off" to IR "Max." Overall, the closest match for a given EID reconstruction kernel/IR strength was identified as a PCCT kernel with "sharpness" increased by 1 step and IR strength increased by 1-2 steps. Substantial dose reduction potential of up to 70% was found when targeting a constant noise magnitude.
Video-rate centimeter-range optical coherence tomography based on dual optical frequency combs by electro-optic modulators (2018)

Imaging speed and range are two important parameters for optical coherence tomography (OCT). A conventional video-rate centimeter-range OCT requires an optical source with hundreds of kHz repetition rate and needs the support of broadband detectors and electronics (>1 GHz). In this paper, a type of video-rate centimeter-range OCT system is proposed and demonstrated based on dual optical frequency combs by leveraging electro-optic modulators. The repetition rate difference between dual combs, i.e. the A-scan rate of dual-comb OCT, can be adjusted within 0~6 MHz. By down-converting the interference signal from optical domain to radio-frequency domain through dual comb beating, the down-converted bandwidth of the interference signal is less than 22.5 MHz which is at least two orders of magnitude lower than that in conventional OCT systems. A LabVIEW program is developed for video-rate operation, and the centimeter imaging depth is proved by using 10 pieces of 1-mm thick glass stacked as the sample. The effective beating bandwidth between two optical comb sources is 7 nm corresponding to ~108 comb lines, and the axial resolution of the dual-comb OCT is 158 µm. Dual optical frequency combs provide a promising solution to relax the detection bandwidth requirement in fast long-range OCT systems.
Alternative RNA of Epsilon Transcripts Produces mRNAs Encoding Two Membrane and Four Secreted IgE Isoforms (1995)

We elucidated a series of alternatively spliced human epsilon mRNAs by employing a human epsilon-specific RT-PCR strategy. Two mRNA isoforms provide for the expression of distinct membrane IgE proteins, the common form of which contains a novel 56-amino-acid sequence after the last epsilon constant-region domain. Other mRNAs encode, in addition to the classic secreted epsilon chain, at least three novel epsilon secreted proteins that lack a transmembrane domain and possess distinctive C-terminal features. Furthermore, the expression of these epsilon mRNA isoforms is differentially regulated by stimuli such as interleukin-10, Fc epsilon RII cross-linking and aromatic hydrocarbons found in diesel exhaust.
Production of Aspergillus xylanase by lignocellulosic waste fermentation and its application (1999)

Strains of Aspergillus terreus and A. niger, known to produce xylanase with undetectable amounts of cellulase, were studied for xylanase (EC 3.2.1.8) production on various lignocellulosic substrates using solid state fermentation. Of the lignocellulosic substrates used, wheat bran was the best for xylanase production. The effects of various parameters, such as moistening agent, level of initial moisture content, temperature of incubation, inoculum size and incubation time, on xylanase production were studied. The best medium for A. terreus was wheat bran moistened with 1:5 Mandels and Strenberg mineral solution containing 0.1% tryptone, at 35 degrees C, and at inoculum concentration 2x107-2x108 spores 5 g-1 substrate; for A. niger, the best medium was wheat bran moistened with 1:5 Mandels and Strenberg mineral solution containing 0.1% yeast extract, at 35 degrees C, and at an inoculum concentration of 2x107-2x108 spores 5 g-1 substrate. Under these conditions, A. terreus produced 68.9 IU ml-1 of xylanase, and A. niger, 74.5 IU ml-1, after 4 d of incubation. A crude culture filtrate of the two Aspergillus strains was used for the hydrolysis of various lignocellulosic materials. Xylanase preparations from the two strains selectively removed the hemicellulose fraction from all lignocellulosic materials tested.
국내 영유아 자폐스펙트럼장애의 SACS-K 적용 (2016)

본 연구는 자폐스펙트럼장애, 발달지연, 일반 영유아를 대상으로 Barbaro와 Dissanayake(2010)의 The Social Attention and Communication Study(SACS) 18개월, 24개월용을 실시하여 국내 적용의 타당성을 알아보고 영유아 자폐스펙트럼장애 선별을 위한 주요 지표를 발견하였다. 무선으로 선발된 일반 영유아...
Fixation for distal radius fractures. (1997)

Distal radius fractures are common fractures that can cause significant disability. As techniques and implants have improved, better results can be expected from internal and external fixation of complex wrist fractures. With meticulous technique, articular alignment can be secured and small articular fragments can be replaced in anatomic locations through limited open or arthroscopic techniques. Bone graft should be used liberally in comminuted articular fractures. Such procedures are demanding, however. Familiarity with the techniques described in this article will enhance the surgeon's ability to restore function in this group of patients.
The bitter Asteraceae: An interesting approach to delay the metabolic syndrome progression (2020)

The prevalence of metabolic syndrome (METS) directly correlates with the prevalence of obesity, and it is associated with several other risk factors. Among them, chronic inflammation, oxidative stress and insulin resistance might be reduced in order to delay the progression of METS. The first management of METS involves physical exercises and a suitable diet. Many Asteraceae are plants commonly consumed. The bitter Asteraceae known for their health effect are traditionally used as bitter drinks. Their particularly rich contents in sesquiterpene lactones and hydroxy-cinnamic acids mainly in caffeoyl derivatives, confer to these plants good anti-METS potential. These compounds are known for their antioxidant, anti-inflammatory and insulin sensitizing effects and confer to bitter Asteraceae the potential to be good candidate products to delay METS.
Predictive Resource Management for Wearable Computing (2003)

Article Share on Predictive Resource Management for Wearable Computing Authors: Dushyanth Narayanan View Profile , M. Satyanarayanan View Profile Authors Info & Claims MobiSys '03: Proceedings of the 1st international conference on Mobile systems, applications and servicesMay 2003Pages 113–128https://doi.org/10.1145/1066116.1189041Published:05 May 2003Publication History 41citation384DownloadsMetricsTotal Citations41Total Downloads384Last 12 Months6Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access