gebhart/patrepeval huggingface dataset:
Pathophysiology and treatment of α1-antitrypsin deficiency (1995)

The pathophysiology of alpha 1-antitrypsin (AAT) deficiency and the use of alpha 1-proteinase inhibitor therapy in the management of emphysema caused by AAT deficiency are described. AAT deficiency is the most common genetic cause of liver disease in children and emphysema in adults. However, not all patients with AAT deficiency develop hepatic or pulmonary involvement. Changes in the composition of the AAT molecule have been associated with AAT dysfunction in liver disease, whereas lung disease occurs when AAT concentrations are reduced. A definitive diagnosis can be made through serum AAT phenotype determination. Therapy for liver disease induced by AAT deficiency consists of supportive measures. Therapy for pulmonary disease due to AAT deficiency includes AAT augmentation therapy along with supportive measures. The available product, alpha 1-proteinase inhibitor, is derived from fractionated plasma and has similar biological activity to native serum AAT. Clinical trials have demonstrated a positive effect on serum and lung concentrations of AAT with few adverse events. Two recombinant forms of AAT have also been developed; however, few trials have been published evaluating their safety and efficacy in AAT-deficient patients. Many questions remain unanswered concerning AAT deficiency and replacement therapy. AAT augmentation therapy appears to reduce the progression of emphysema in some AAT-deficient patients.
Characterization of antiradical and anti-inflammatory activities of some coldpressed oils in carrageenan-induced rat model of acute inflammation (2016)

Inflammation is a process involving multiple factors acting in a complex network, where a distinct cytokine cascade of pro-inflammatory and inflammatory mediators unfolds. Substantial levels of bioactive phytochemicals were found in cold-pressed oils (CPO). To evaluate the antiradical and anti-inflammatory potential of CPO including Nigella sativa oil (BCO), Coriandrum sativum oil (COO), and Syzygium aromaticum oil (CLO). Indomethacin was used as the reference standard. In vitro assays were undertaken to evaluate radical scavenging properties utilizing stable 1,1-diphenyl-2-picrylhydrazyl (DPPHA‹Â™) and galvinoxyl radicals. In vivo studies comprised carrageenan (CG)- induced rat paw edema as a model for acute inflammation. Biochemical estimations of tumor necrosis factor-α (TNFα), interleukin 6 (IL-6), and interleukin 12 (IL-12) were evaluated in paw exudates and sera of treated as well as untreated animals groups. Histopathological examination of rat paw sections was carried out. In vitro assays revealed strong radical scavenging potential of CPO against stable DPPHA‹Â™ and galvinoxyl radicals with CLO showing the highest radical quenching activity. Pro-inflammatory cytokine levels were markedly improved as compared to untreated CG group. CLO exhibited superior attenuation of pro-inflammatory release as compared to BCO, COO, and indomethacin. Rat paw sections of CPO-treated groups showed a marked improvement in histopathological alterations induced by CG injection. Attenuation of inflammatory mediators by bioactive constituents of the selected CPO, together with the antioxidant potential, might represent a possible prophylactic or therapeutic target against inflammation and subsequent free radical generation.
Carrier accumulation enhanced Auger recombination and inner self-heating-induced spectrum fluctuation in CsPbBr3 perovskite nanocrystal light-emitting devices (2019)

Light-emitting devices (LEDs) based on colloidal semiconductor nanocrystals (NCs) are promising next-generation thin-film display and lighting devices owing to their high luminescence efficiency and size-tunable color. However, the studies of the carrier transport and recombination mechanisms of the NC-LEDs lag far behind. We study the operation mechanisms of the CsPbBr3 NC-LEDs with a working voltage as high as 40 V. They exhibit an anomalous hump-shaped bias dependence of luminescence intensity. A theoretical model is proposed to explain this, and it indicates that there is enhanced Auger recombination in the CsPbBr3 NC-LEDs caused by imbalanced carrier accumulation, which causes efficiency droop similar to that in the nitride-based light-emitting diodes. We also report the intriguing phenomenon of electroluminescence spectrum fluctuation of the CsPbBr3 NC-LEDs, which is ascribed to the inner self-heating effect in the emission layer.
Combining relational algebra, SQL, constraint modelling, and local search (2007)

Abstract The goal of this paper is to provide a strong integration between constraint modelling and relational DBMSs. To this end we propose extensions of standard query languages such as relational algebra and SQL , by adding constraint modelling capabilities to them. In particular, we propose non-deterministic extensions of both languages, which are specially suited for combinatorial problems. Non-determinism is introduced by means of a guessing operator, which declares a set of relations to have an arbitrary extension. This new operator results in languages with higher expressive power, able to express all problems in the complexity class NP. Some syntactical restrictions which make data complexity polynomial are shown. The effectiveness of both extensions is demonstrated by means of several examples. The current implementation, written in Java using local search techniques, is described.
High amplification laser-pressure optic enables ultra-low uncertainty measurements of optical laser power at kilowatt levels (2021)

We present the first measurements of kilowatt laser power with an uncertainty less than 1 %. These represent progress toward the most accurate measurements of laser power above 1 kW at 1070 nm wavelength and establish a more precise link between force metrology and laser power metrology. Radiation pressure, or photon momentum, is a relatively new method of non-destructively measuring laser power. We demonstrate how a multiple reflection optical system amplifies the pressure of a kilowatt class laser incoherently to improve the signal to noise ratio in a radiation pressure-based measurement. With 14 incoherent reflections of the laser, we measure a total uncertainty of 0.26 % for an input power of 10 kW and 0.46 % for an input power of 1 kW at the 95 % confidence level. These measurements of absolute power are traceable to the SI kilogram and mark a state-of-the-art improvement in measurement precision by a factor of four.
FlexDPDP: FlexList-based Optimized Dynamic Provable Data Possession. (2013)

With popularity of cloud storage, efficiently proving the integrity of data stored at an untrusted server has become significant. Authenticated Skip Lists and Rank-based Authenticated Skip Lists (RBASL) have been used in cloud storage to provide support for provable data update operations. In a dynamic file scenario, an RBASL falls short when updates are not proportional to a fixed block size; such an update to the file, however small, may translate to O(n) many block updates to the RBASL, for a file with n blocks. To overcome this problem, we introduce FlexList: Flexible Length-Based Authenticated Skip List. FlexList translates even variable-size updates to O(u) insertions, removals, or modifications, where u is the size of the update divided by the block size. We present various optimizations on the four types of skip lists (regular, authenticated, rank-based authenticated, and FlexList). We compute one single proof to answer multiple (non-)membership queries and obtain efficiency gains of 35%, 35 % and 40 % in terms of proof time, energy, and size, respectively. We also deployed our implementation of FlexDPDP (DPDP with FlexList instead of RBASL) on PlanetLab, demonstrating that FlexDPDP performs comparable to the most efficient static storage scheme (PDP), while providing dynamic data support.
Anaplastic lymphoma kinase (ALK) inhibitors: a review of design and discovery (2014)

This review elucidates the hit-to-drug evolution design of three ALK inhibitors.
Fast Track: A Software System for Speculative Program Optimization (2009)

Fast track is a software speculation system that enables unsafe optimization of sequential code. It speculatively runs optimized code to improve performance and then checks the correctness of the speculative code by running the original program on multiple processors. We present the interface design and system implementation for Fast Track. It lets a programmer or a profiling tool mark fast-track code regions and uses a run-time system to manage the parallel execution of the speculative process and its checking processes and ensures the correct display of program outputs. The core of the run-time system is a novel concurrent algorithm that balances exploitable parallelism and available processors when the fast track is too slow or too fast. The programming interface closely affects the run-time support. Our system permits both explicit and implicit end markers for speculatively optimized code regions as well as extensions that allow the use of multiple tracks and user designed correctness checking. We discuss the possible uses of speculative optimization and demonstrate the effectiveness of our prototype system by examples of unsafe semantic optimization and a general system for fast memory-safety checking, which is able to reduce the checking time by factors between 2 and 7 for large sequential code on a 8-CPU system.
Multispecificity of Drug Transporters: Probing Inhibitor Selectivity for the Human Drug Efflux Transporters ABCB1 and ABCG2 (2007)

Multidrug resistance transporters P-glycoprotein/ABCB1 and ABCG2 limit the effect of a large number of cytostatic and cytotoxic drugs by energy-dependent efflux. In experimental models, pump inhibitors reestablish sensitivity towards these drugs. Both transporters demonstrate remarkably broad and partly overlapping substrate specificity. Propafenone analogues are inhibitors of a large number of drug efflux pumps including P-glycoprotein and ABCG2 as well as the microbial pumps. Here the two human ABC transporters ABCB1 and ABCG2 have been studied with respect to interaction with this class of compounds. Data indicate that within the same chemical scaffold, selectivity indices span three orders of magnitude. Compounds with the highest selectivity indices contain a non-ionizable nitrogen atom. Qualitative and quantitative pharmacophore models indicate that hydrophobicity, the number of rotatable bonds, and the number of H-bond acceptors are key features for both activity and selectivity.
Multi-level Hashing for Peer-to-Peer System in Wireless Ad Hoc Environment (2007)

Peer-to-peer is a popular distributed system. With the advancement in mobile technologies, mobile P2P has revealed its attraction. But, the resource constraints such as bandwidth, computing power, energy, etc. and node's mobility give hard challenges to the researchers. Smart content distribution and efficient content discovery are the heart of P2P protocols. Routing is associated with every task but it is expensive in ad hoc environment. In this paper, we address these issues and present a peer-to-peer system for wireless ad-hoc networks using multi-level hashing to reduce routing overhead. The necessity of multilevel hashing is justified through extensive simulation
A research on carrier frequency offset estimation for 5G telecommunication (2014)

Unlike the conventional OFDM system, many candidates for the 5G telecommunication such as GFDM and FBMC suggest non-orthogonal and asynchronous waveform transmission. While conventional OFDM system usually measures CFO with repetition pattern in time domain, the 5G telecommunication's non-orthogonality requires frequency domain CFO measurement. This paper presents the CFO measurement method for 5G telecommunication and evaluates its performance.
Net Ecosystem CO2 Flux and Effect Factors in Peatland Ecosystem of Central China (2020)

Peatland ecosystems play an important role in the global carbon cycle because they act as a pool or sink for the carbon cycle. However, the relationship between seasonality effect factors and net ecosystem CO2 exchange (NEE) remains to be clarified, particularly for the non-growing season. Here, based on the eddy covariance technique, NEE in the peatland ecosystem of Central China was examined to measure two years’ (2016 and 2017) accumulation of carbon dioxide emissions with contrasting seasonal distribution of environmental factors. Our results demonstrate the cumulative net ecosystem CO2 emissions during the study period was in the first non-growing season 2.94 ± 4.83 μmolCO2 m-2.s-1 with the lowest values in the same year in first growing season was -2.79 ± 4.92 μmolCO2 m-2.s-1. The results indicate the effect of seasonal variations of NEE can be directly reflected in daily and seasonal variations in growth and respiration of peatland ecosystem by environmental parameters over different growing stages.
Bibliographie chronologique des publications de Walter J. Ganshof Van Der Meersch (1972)

info:eu-repo/semantics/published
Fabrication of Microelectronic Devices (2012)

The second part of the past century is known as the silicon age, and the backbone of this era is the precise manufacturing of circuit elements on a single-crystal Si wafer. This particular technology of semiconductor processing is known as planar technology, and it makes the integration of a large number of electronic components on a single wafer possible [1]. The miniaturization of individual devices to make large-scale integrated circuits would not have been possible without the advances in processes, techniques, and equipment. The availability of cheap electronics today is a testimony to the advances that have taken place over the past 50 years. Advances in microelectronic device fabrication have led to new elds such as microelectromechanical systems (MEMS) [2]. In microelectronic circuits, there is no physical displacement between components, while MEMS processing is done toallow physical displacement of components. To a very large extent, today’s nanofabrication technology also has its lineage in microelectronics fabrication as many tools developed to work at the microrange have been improved and enhanced to provide nanolevel observation and manipulation.
Flavor Constituents of Beef as Influenced by Forage‐ and Grain‐Feeding (1987)

ABSTRACT Hereford yearling steers (N= 144) were alloted to one of three pasture systems: tall fescue, smooth bromegrass‐red clover or orchardgrass‐red clover. After the grazing period, steers were finished in drylot and then serially slaughtered at 0, 56, 84 and 112 days. Carcass quality grades and yield grade numbers increased when steers were fed grain up to 112 days. Tenderness of loin steaks increased up to 84 days, after which no improvements were observed. Sensory panel scores for grassy flavor of steaks and ground beef decreased up to 112 days. Fifty‐three compounds were identified in the volatiles of melted subcutaneous fat by direct sampling‐gas chromatography/mass spectro‐metry. The major differences between volatiles from fat of forage‐fed compared to grain‐fed steers were the higher concentrations of 2,3‐octanedione and various diterpenoids present in the samples of the forage‐fed animals.
Novel techniques for the prepartion of synthetic diamond (1990)

Abstract The objectives of this work are two fold: (1) to study the effect of using oxygen-acetylene flame grown synthetic diamond as seed crystals for the high pressure-high temperature conversion of graphite into diamond and (2) to demonstrate the ability to produce small crystallites of diamond by a simple, electron beam evaporation technique. In each case, the production of diamond from graphite was confirmed.
Type IIA procollagen NH2-propeptide functions as an antagonist of bone morphogenetic proteins (2002)

Knowledge of how growth factors are regulated in the extracellular matrix is crucial for understanding processes of tissue development and repair. A complex series of processes occurs in the extracellular matrix to control the activity and distribution of bone morphogenetic proteins (BMPs), which are important factors during cartilage and bone development. It is known that tissue regeneration is a recapitulation of processes in embryonic development and morphogenesis. Thus, in the case of cartilage repair during osteoarthritis, we can apply our knowledge of BMP function/regulation during embryogenesis to developing therapeutic strategies that will induce and even prolong natural tissue repair.
Field trial using Flight Control as a repellent for Canada goose (Branta canadensis) control in Fort Collins, Colorado (1998)

Flight Control, containing anthraquinone, was field tested during 1997 in Colorado as a repellent to keep Canada geese (Branta canadensis) off turf. The product was sprayed at a rate of 1.9 kg per ha, using a boom sprayer towed by a golf cart. The reduction in goose numbers on the treatment plot was 95.1% ten days after application. A decline of 64.7% in the number of goose droppings on the area was recorded.
The diffraction theory of aberrations (1951)

A historical and critical survey is given of investigations concerned with image formation in optical instruments in the presence of aberrations. The development of the subject is traced from the early researches of Airy on an aberration-free image. The advances made in recent years are discussed in greater detail; these mainly concern the effects of small aberrations, tolerance criteria, and the asymptotic treatment of diffraction problems. A section is also included on investigations into the effects of waves of non-uniform amplitude. The detailed light distribution in typical images is illustrated by isophote-diagrams and photographs.
Biomechanical Ambulatory Assessment of 3D Knee Angle Using Novel Inertial Sensor-Based Technique (2021)

Three-dimensional (3D) knee angle measurement is one of the key measures in human gait analysis. Inertial sensor capable of measuring joint motion under unconstrained conditions is a practical tool for clinical evaluation and rehabilitation. An inertial measurement unit (IMU) consisting of accelerometer and gyroscope allows orientation measurement in 3D with an additional sensor (i.e., magnetometer). However, ferromagnetic interference negatively affects the performance of magnetometer and thus reduces measurement accuracy. In this study, a technique based on nonlinear autoregressive neural network with exogenous inputs (NARX) is presented to measure 3D segmental orientation during gait without the use of magnetometer. With IMUs attached to the thigh and shank, 3D knee angles in long-distance treadmill walking were computed and validated against an optical motion analysis system as the gold standard. Pseudo-integrator (PI) was also compared to the reference system for benchmarking. The learning capability of NARX was further assessed with the comparison of complementary filter (CF) to the reference system. The proposed NARX model was shown to outperform PI with biases between -3.5° and -0.2°, and root mean square errors between 4.5° and 2.5°. Results demonstrated the capability of NARX in providing accurate estimates of 3D knee joint angle while avoiding interference as encountered in systems incorporating magnetometer, suggesting that NARX is feasible to computing long-term ambulatory measurements of body segment orientation and 3D joint angles.
Decoding Reed-Muller codes over product sets (2015)

We give a polynomial time algorithm to decode multivariate polynomial codes of degree $d$ up to half their minimum distance, when the evaluation points are an arbitrary product set $S^m$, for every $d &lt; |S|$. Previously known algorithms can achieve this only if the set $S$ has some very special algebraic structure, or if the degree $d$ is significantly smaller than $|S|$. We also give a near-linear time randomized algorithm, which is based on tools from list-decoding, to decode these codes from nearly half their minimum distance, provided $d &lt; (1-ε)|S|$ for constant $ε&gt; 0$. Our result gives an $m$-dimensional generalization of the well known decoding algorithms for Reed-Solomon codes, and can be viewed as giving an algorithmic version of the Schwartz-Zippel lemma.
Special Issues in Flash (2008)

While flash memory has been widely adopted in the implementations of various storage systems, it recently receives a lot of attention in various system-component designs. With the unique characteristics of flash memory, it is highly challenging in the designs of management software, especially when reliability and cost management become major concerns. In this paper, popular implementations of the management software will be summarized, and the behavior analysis of flash-memory storage systems will then be addressed. Challenge issues for current and future implementations, especially on reliability and filesystem considerations, and some potential solutions will be presented.
(precursor/secretory polypeptide/wheat germ extract) (2016)

Translation of melittin messenger RNA from queen bee venom glands in a cell-free system from w)heat germ yielded prepromelittin. Sequence analysis of the labeled in vitro product was performed by automatic Edman degradation of the intact polypeptide as well as by analysis of some of its proteo- lytic fragments. Prepromelittin was shown to be composed of 70 amino acids, two of which have not been identified. The se- quence of melittin is located in the COOH-terminal third of the polypeptide chain (residues 44-69). Prepromelittin starts with a very hydrophobic pre-region, probably 21 residues long, fol- lowed by a pro-part of unusual sequence, containing only ala- nine, proline, and acidic residues. At least three post-transla- tional reactions are required to convert prepromelittin to mel- ittin.
Generalized radiance and practical radiometry (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Walter Welford and Roland Winston, "Generalized radiance and practical radiometry," J. Opt. Soc. Am. A 4, 545-547 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin (2022)

Objective(s): 18F-FDG PET/CT is increasingly performed in patients with differen-tiated thyroid cancer. The aim of this study was to assess the clinical impact of 18F-FDG PET/CT on the management of patients with differentiated thyroid carcinoma who had elevated serum thyroglobulin (Tg) and negative 131I whole body scan (WBS). Methods: 67 patients with differentiated thyroid carcinoma were included in this study. The findings of 18F-FDG PET/CT imaging were compared with histo-pathology, follow up imaging, or clinical follow-up results. The diagnostic accuracy of 18F-FDG PET/CT was evaluated for the entire patient group and for those patients with stimulated serum thyroglobulin levels of less than 5, 5–10, and more than 10 pmol/L as well as for local recurrences and metastases sites. The impact of 18F-FDG PET/CT on therapeutic management was also evaluated. Results: 30/67 patients had positive findings on 18F-FDG PET/CT; 28 were true-positive and 2 were false-positive. 18F-FDG PET/CT results were true-negative in 36 patients and false-negative in 1 patient. The overall sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT were, 96.5%, 94.5%, 95.5%, 93.3%, and 97.2% respectively. Positive 18F-FDG PET/CT findings were directly correlated with stimulated serum thyroglobulin levels, 7.1% had Tg between 5–10, and 92.9% had Tg greater than 10 pmol/L. 18F-FDG PET/CT had a high or moderate impact on treatment management in 28 (41.8%) of patients. Conclusion: 18F-FDG PET/CT is able to improve diagnostic accuracy and have management impact in a therapeutically relevant way in patients with differentiated thyroid carcinoma who present with rising thyroglobulin level, negative 131I WBS, and clinical suspicion of recurrent disease.