gebhart/patrepeval huggingface dataset:
MECHANISM AND KINETICS OF THE UNCATALYZED MERCURY(I)-CERIUM(IV) REACTION (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMECHANISM AND KINETICS OF THE UNCATALYZED MERCURY(I)-CERIUM(IV) REACTIONW. H. McCurdy Jr. and G. G. GuilbaultCite this: J. Phys. Chem. 1960, 64, 12, 1825–1827Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/j100841a006https://doi.org/10.1021/j100841a006research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The State of Neuro-Oncology During the COVID-19 Pandemic: A Worldwide Assessment (2020)

Background It remains unknown how the COVID-19 pandemic has changed neuro-oncology clinical practice, training, and research efforts. Methods We performed an international survey of practitioners, scientists, and trainees from 21 neuro-oncology organizations across 6 continents, April 24-May 17, 2020. We assessed clinical practice and research environments, institutional preparedness and support, and perceived impact on patients. Results Of 582 respondents, 258 (45%) were US-based and 314 (55%) international. Ninety-four percent of participants reported changes in their clinical practice. Ninety-five percent of respondents converted at least some practice to telemedicine. Ten percent of practitioners felt the need to see patients in person, specifically because of billing concerns and pressure from their institutions. Sixty-seven percent of practitioners suspended enrollment for at least one clinical trial, including 62% suspending phase III trial enrollments. More than 50% believed neuro-oncology patients were at increased risk for COVID-19. Seventy-one percent of clinicians feared for their own personal safety or that of their families, specifically because of their clinical duties; 20% had inadequate personal protective equipment. While 69% reported increased stress, 44% received no psychosocial support from their institutions. Thirty-seven percent had salary reductions and 63% of researchers temporarily closed their laboratories. However, the pandemic created positive changes in perceived patient satisfaction, communication quality, and technology use to deliver care and mediate interactions with other practitioners. Conclusions The pandemic has changed treatment schedules and limited investigational treatment options. Institutional lack of support created clinician and researcher anxiety. Communication with patients was satisfactory. We make recommendations to guide clinical and scientific infrastructure moving forward and address the personal challenges of providers and researchers.
Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. (1998)

The D values primarily reflect overall brain water content. The A sigma values are more sensitive to tissue microstructure (e.g., white matter packing and myelination). The D and A sigma images reveal information and not apparent on T1- and T2-weighted images.
Toward Engineering a Novel Transplantation Site for Human Pancreatic Islets (2013)

slet transplantation is a promising therapy for treatment of type 1 diabetes.A real breakthrough was reported when the Edmonton protocol was introduced in 2000.This protocol induced insulin independence in diabetic patients for 1 year (1).Although these clinical islet transplantations demonstrated the application of the technique, the long-term function of the islet grafts was not that successful.After 2 years, less than 50% of the patients remained insulin independent.Five years following transplantation, this declined to just 10% (1).In recent years, some groups demonstrated remarkable progress in islet transplantation outcomes (2), and experienced groups have been able to produce insulin independence after transplantation of islets from a single donor by controlling all known parameters for optimal islet donation (3).Recently, a number of groups have focused on the identification of factors determining success or failure of islet grafts.Various signs point to the transplantation site as a major factor in graft failure.The majority of islet transplantation is currently accomplished by the infusion of islets into the liver via the portal vein.Several alternative sites were investigated in animals and humans for efficacy as transplantation sites for islets, but none adequately accommodated islet engraftment.A rather novel approach that has been investigated recently is the engineering of an artificial site by using biopolymeric scaffolds.These scaffolds facilitate revascularization and allow adequate glucose sensing and insulin release.Recent developments in this area are reviewed in this article because of their potential clinical application.
Supplementary Figure 1 from Platelets and P-Selectin Control Tumor Cell Metastasis in an Organ-Specific Manner and Independently of NK Cells (2023)

&lt;p&gt;PDF file, 905K, Antibody-mediated NK-cell depletion.&lt;/p&gt;
The trouble with isolation by distance (2012)

The genetic population structure of many species is characterised by a pattern of isolation by distance (IBD): due to limited dispersal, individuals that are geographically close tend to be genetically more similar than individuals that are far apart. Despite the ubiquity of IBD in nature, many commonly used statistical tests are based on a null model that is completely non-spatial, the Island model. Here, I argue that patterns of spatial autocorrelation deriving from IBD present a problem for such tests as it can severely bias their outcome. I use simulated data to illustrate this problem for two widely used types of tests: tests of hierarchical population structure and the detection of loci under selection. My results show that for both types of tests the presence of IBD can indeed lead to a large number of false positives. I therefore argue that all analyses in a study should take the spatial dependence in the data into account, unless it can be shown that there is no spatial autocorrelation in the allele frequency distribution that is under investigation. Thus, it is urgent to develop additional statistical approaches that are based on a spatially explicit null model instead of the non-spatial Island model.
Sensitivity of piezoelectric wafers to the curing of thermoset resins and thermoset composites (1998)

In-plane vibration of a piezoelectric wafer can be excited by electric voltage across its thickness in the poled direction. Such a characteristic, in turn, builds up a relationship between mechanical and electrical performance of the wafer. The relationship is here especially analysed as the piezoelectric wafer is immersed in a liquid that is modelled by a series of mass-spring-damper systems attached to the wafer. Results demonstrate that mechanical properties such as modulus, mass and damping coefficient of the systems have impact on the capacitance, inductance and resistance of the piezoelectric wafer referred to a component in an electric circuit. Changes in the properties alter the electric resonant response behaviour of the circuit. Two experiments for the curing process of epoxy and a thermoset composite verify the prediction that the variation in amplitude of a transfer function in a resonant region is dominated by the change in viscosity of resins before gelation, while it is mostly affected by the change in temperature after gelation. The paper presents an approach to sense the curing process of thermoset resins and thermoset composites by the electromechanical property of the piezoelectric wafers.
Statistics of mode competition in a miniature TEA CO2laser (1985)

Measurements are presented of the statistics of the energy distribution between the longitudinal modes of a miniature TEA CO2 laser. Correlations exist between the fluctuations on different modes, on account of competition for the limited available excitation energy. The fluctuations on each mode are characteristic of the effects of quantum fluctuations in the radiation in the mode early in the pulse while the laser is near threshold.
A Language and Platform Independent Co-Simulation Framework Based on the Functional Mock-Up Interface (2019)

The main goal of the Functional Mock-up Interface (FMI) standard is to allow the sharing of simulation models across tools. To accomplish this, FMI relies on a combination of XML-files and compiled C-code packaged in a zip archive. This archive is called a Functional Mock-up Unit (FMU). In theory, an FMU can support multiple platforms, but not necessarily in practice. Furthermore, software libraries for interacting with FMUs may not be available in a particular language or platform. Another issue is related to the protection of intellectual property (IP). While an FMU is free to only provide the C-code in its binary form, other resources within the FMU may be unprotected. Distributing models in binary form also opens up the possibility that they may contain malicious code. In order to meet these challenges, this paper presents an open-source co-simulation framework based on FMI, which is language and platform independent thanks to the use of well-established remote procedure call (RPC) technologies. One or more FMUs are wrapped inside a server program supporting one or more language independent RPC systems over various network protocols. Together, they allow cross-platform invocation of FMUs from multiple, including previously unsupported, languages. The client-server architecture allows the effective protection of IP while also providing a means of protecting users from malicious code.
Secure Network Coding with a Cost Criterion (2006)

Network cost and network security are two of many network parameters that are important to network users. While these two parameters have been separately considered in coded networks (networks that employ network coding), a joint investigation of them both has not been done yet to our knowledge, thus providing the motivation for this work. In this paper, we consider the situation where a set of messages is to be multi-casted across the network, and a known subset of these messages is of interest to a wiretapping adversary. The problem that we attempt to solve is to find a network coding scheme that has both a low network cost and a low probability of the wiretapper being able to retrieve all the messages of interest. We make use of random linear codes in anticipation for decentralized implementation of the scheme, and focus on the problem of finding the multicast subgraph. As an exact algorithmic solution is difficult, we propose two heuristic solutions, and compare their performances to traditional routing through a simulation study. Our results suggest that network coding can be more effective than routing for this low cost and secure data multicast problem, especially when the links are not easily tapped.
Potentiation of Synaptic AMPA Receptors Induced by the Deletion of NMDA Receptors Requires the GluA2 Subunit (2010)

Deletion of N-methyl-D-aspartate receptors (NMDARs) early in development results in an increase in the number of synaptic AMPA receptors (AMPARs), suggesting a role for NMDARs in negatively regulating AMPAR trafficking at developing synapses. Substantial evidence has shown that AMPAR subunits function differentially in AMPAR trafficking. However, the role of AMPAR subunits in the enhancement of AMPARs following NMDAR ablation remains unknown. We have now performed single-cell genetic deletions in double-floxed mice in which the deletion of GluN1 is combined with the deletion of GluA1 or GluA2. We find that the AMPAR enhancement following NMDAR deletion requires the GluA2 subunit, but not the GluA1 subunit, indicating a key role for GluA2 in the regulation of AMPAR trafficking in developing synapses.
GAMYB and BPBF transcriptional factors in the control of gene expression during development of barley endosperm. (2003)

During cereal seed development, the starchy endosperm cells accumulate&#13;\nproteins, mainly prolamines, as well as several antimicrobial peptides and&#13;\ninhibitors of heterologous hydrolases implicated in plant defence (Shewry et&#13;\nal ., 1995; Carbonero et al ., 1999). The genes encoding the storage proteins are&#13;\ncoordinately expressed in the developing endosperm where they are under&#13;\nspatial and temporal transcriptional control, involving cis-acting motifs in&#13;\ntheir promoters and trans-acting transcriptional factors (TFs). A number of&#13;\nconsensus sequences in gene promoters have been shown to be involved in&#13;\nconferring endosperm specificity in cereals (Albani et al ., 1997; Marzabal et&#13;\nal ., 1998; Mena et al ., 1998; Vicente-Carbajosa et al ., 1998; Oñate et al ., 1999;&#13;\nCarbonero et al ., 2000; Wu et al ., 2000; Díaz et al ., 2002). A conserved cis-acting&#13;\nmotif found in most storage protein gene promoters of seeds is the&#13;\nendosperm-box, a bipartite motif located ~300 bp upstream of the translation initiation codon that contains two distinct binding sites: the GCN4-like&#13;\nmotif (GLM) motif (5´-ATGAG/CTCAT-3´) that resembles the yeast GCN4&#13;\nmotif and the prolamine box (PB: 5´-TGTAAAG-3´). There is a third motif&#13;\n(5´-AACA/TA-3´), which plays a role in the expression of genes encoding&#13;\n§ glutelins in rice (Suzuki et al ., 1998). These three types of motifs are the target&#13;\nsites of different TFs.&#13;\nIn barley, the GLM is recognized by bZIP proteins of the Opaque2 family&#13;\n(BLZ1 and BLZ2) that through dimer formation, as either homo- or heterodimers (Vicente-Carbajosa et al ., 1998; Oñate et al ., 1999), trans-activate the&#13;\nexpression of endosperm-specific genes such as the Hor2 and Itr1 genes encoding the B-hordeins and a trypsin inhibitor, respectively. The prolamine&#13;\nbox is recognized by a TF of the DOF class, DNA binding with One Finger&#13;\n(BPBF), that activates transcription of a native Hor2 promoter in co-bombarded barley endosperms through binding to the prolamine box (PB)&#13;\nWe describe here how the&#13;\n5´-AACA/TA-3´ motif interacts with a TF of the MYB class, which was previously shown to have a role in the activation of gibberellin (GA)-induced&#13;\ngenes upon germination in barley aleurone cells (Gubler et al ., 1995, 1999).
A 1–11 GHz ultra‐wideband LNA using M‐derived inductive peaking circuit in UMC 65 nm CMOS (2017)

ABSTRACT A high‐gain, low‐power, and low‐noise amplifier (LNA) is designed in UMC 65 nm radio frequency (RF)‐CMOS technology for operation over the 1 to 11 GHz RF band. This LNA design is based on an m‐derived inductive peaking circuit with a shunt feedback inverter. The m‐derived inductive peaking circuit is placed between two shunt feedback inverters. Further, a split inductor topology is introduced in the circuit. The procedure for the integrating of an m‐derived inductive peaking circuit in LNA is explained in detail. The proposed circuit achieves more than 14 dB of power gain over an ultra‐wideband of 1 to 11 GHz. The measurement of the proposed LNA achieves a minimum of 2.5 dB of noise figure, and more than −8 dBm of third‐order input intercept point, while consuming 11.3 mW of power. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:521–526, 2017
Systematic scalability analysis for microservices granularity adaptation design decisions (2022)

Abstract Microservices have gained wide recognition and acceptance in software industries as an emerging architectural style for autonomous, scalable and more reliable computing. A critical problem related to microservices is reasoning about the suitable granularity level of a microservice (i.e., when and how to merge or decompose microservices). Although scalability is pronounced as one of the major factors for adoption of microservices, there is a general gap of approaches that systematically analyse the dimensions and metrics, which are important for scalability‐aware granularity adaptation decisions. To the best of our knowledge, the state‐of‐art in reasoning about microservice granularity adaptation is neither: (1) driven by microservice‐specific scalability dimensions and metrics nor (2) follow systematic scalability analysis to make scalability‐aware adaptation decisions. In this article, we address the aforementioned problems using a two‐fold contribution. Firstly, we contribute to a working catalogue of microservice‐specific scalability dimensions and metrics. Secondly, we describe a novel application of scalability goal‐obstacle analysis for the context of reasoning about microservice granularity adaptation. We analyse both contributions by comparing their usage on a hypothetical microservice architecture against ad‐hoc scalability assessment for the same architecture. This analysis shows how both contributions can aid making scalability‐aware granularity adaptation decisions.
Vers un monde d'objets interconnectés (2011)

Interview dans la lettre interne de l'INRIA (www.inria.fr/centre/grenoble/actualites/interview-b.-tourancheau-internet-du-futur)
Abstract P124: Role of Add3 Dysfunction in Renal Epithelial Cells in the Development of Renal Injury in Fhh Rats (2017)

The Fawn Hooded Hypertensive Rat (FHH) is a genetic model of hypertension, in which Add3 has been identified as a candidate gene for renal injury but the mechanism is unknown. The present study examined the effects of knockdown of Add3 on rat renal epithelial (NRK) cells which are the model system for podocytes and proximal tubular cells. Knockdown of the expression of Add3 using a 27-mer Dicer-substrate RNAi (DsiRNA) decreased cell viability using an MTS assay by 50% in comparison to cells treated with vehicle or scrambled DSiRNA (Add3DsiRNA, OD 0.5±0.1; untreated cells 0.9±0.1; NC-1 0.9±0.1; n=8, P&lt;0.001). F-actin immunostaining revealed that Add3 DSiRNA markedly disrupted the cytoskeleton, and the F-actin staining intensity/cell ratio was significantly reduced (untreated 543±47, n=552 cells; NC-1 592±39, n=566 cells; Add3DsiRNA 430±58, n=385 cells, P&lt;0.05). The maximum mitochondrial respiratory rate was reduced in Add3 DsiRNA treated cells (untreated 444±42; NC-1 414±32; Add3 DsiRNA 275±16 pmole/min/μg, P&lt;0.01). Proton leak was higher (untreated 42±3; NC-1 40±4; Add3 DsiRNA 63±5 pmole/min/μg, P&lt;0.002) and oxygen consumption coupled to ATP production was decreased in Add3 DsiRNA treated cells (untreated 229±12, n=9; NC-1 200±12, n=8; Add3 DsiRNA 146±11 pmole/min/μg, n=9, P&lt;0.001). Spare respiratory capacity, an index of cell fitness, was reduced by knockdown of Add3 (untreated 154±42, n=9: NC-1 143±32, n=8; Add3DsiRNA 33±16 pmole/min/μg, n=9, P&lt;0.001). Non-mitochondrial oxygen consumption rate (OCR/μg protein) increased in cells treated with Add3 DsiRNA (untreated 57±7; NC-1 80±11; Add3DsiRNA 116±15 pmole/min/μg, P&lt;0.01) suggesting a possible metabolic switch to glycolytic oxygen consumption. In conclusion, knockdown of Add3 in NRK cells disrupts the actin cytoskeleton, promotes mitochondrial dysfunction and decreases cell viability. Loss of Add3 function may contribute to proteinuria in FHH rats by altering the cytoskeleton and promoting effacement and loss of podocytes and the reuptake of filtered protein in the proximal tubule.
ESTIMATING AR PARAMETER-SETS FOR LINEAR-RECURRENT SIGNALS IN CONVOLUTIVE MIXTURES (2003)

This article investigates a theoretical basis for estimating autoregressive (AR) processes for linear-recurrent signals in convolutive mixtures. Whitening of such signals is sometimes a problem in multichannel blind equalization which is intended to extract the original signals even if the signals are of a convolutive mixture type. This whitening is due to inverse-filtering which deconvolves the AR pro-cesses that generate the linear-recurrent signals. To avoid this excessive deconvolution, it is effective to remove the contributions of such processes from the inverse-filters. Unfortunately, no method seems to have been able to extract the AR parameter-sets for respective signals in-cluded in convolutive mixtures. 1.
Failure of High-Dose Leucovorin To Improve Therapy With the Maximally Tolerated Dose of 5-Fluorouracil: A Murine Study With Clinical Relevance? (1988)

Almost all of the completed and ongoing phase III trials of the leucovorin/5-fluorouracil (LV/5-FU) combination have used either a single-agent 5-FU control arm in which the 5-FU was administered in a different schedule from the LV/5-FU arm or one in which the 5-FU was not at the maximally tolerated dose (MTD). Because both dose intensity and scheduling are known to affect drug activity, the LV/5-FU combination was evaluated in the preclinical CD8F1 murine model of advanced first-passage spontaneous breast tumors using the same dose (at MTD) and schedule for 5-FU alone and in the LV/5-FU combination arm. Overall, therapy with 5-FU at MTD was not improved by LV. Further, although the activity of 5-FU doses lower than the MTD could be increased by LV, the therapeutic result was comparable to that of single-agent 5-FU at MTD. In an evaluation with other modulators of 5-FU (e.g., uridine, PALA, methotrexate), therapy with various modulated 5-FU combinations at their MTD was not improved with LV. In conclusion, although LV can enhance the cytotoxicity of 5-FU in these in vivo preclinical studies, it does not confer enhanced selectivity to 5-FU, a conclusion at odds with many present clinical reports. Whether or not these murine findings have clinical relevance can be determined only by clinical trials designed with the MTD of 5-FU alone in the control arm, the MTD of 5-FU (or as close as tolerated) in the LV/5-FU arm, and identical schedules in both arms.
Crystallization behavior of biodegradable amphiphilic poly(ethylene glycol)-poly(L-lactide) block copolymers (1999)

Poly(ethylene glycol)-poly(L-lactide) diblock and triblock copolymers were prepared by ring-opening polymerization of L-lactide with poly(ethylene glycol) methyl ether or with poly(ethylene glycol) in the presence of stannous octoate. Molecular weight, thermal properties, and crystalline structure of block copolymers were analyzed by 1H-NMR, FTIR, GPC, DSC, and wide-angle X-ray diffraction (WAXD). The composition of the block copolymer was found to be comparable to those of the reactants. Each block of the PEG–PLLA copolymer was phase separated at room temperature, as determined by DSC and WAXD. For the asymmetric block copolymers, the crystallization of one block influenced much the crystalline structure of the other block that was chemically connected to it. Time-resolved WAXD analyses also showed the crystallization of the PLLA block became retarded due to the presence of the PEG block. According to the biodegradability test using the activated sludge, PEG–PLLA block copolymer degraded much faster than PLLA homopolymers of the same molecular weight. © 1999 John Wiley amp; Sons, Inc. J Appl Polym Sci 72: 341–348, 1999