gebhart/patrepeval huggingface dataset:
“Rolling Recruitment” of Endothelial Cell (EC) Activation in the Prothrombotic Nature of Heparin-Induced Thrombocytopenia (HIT) (2011)

Abstract Abstract 536 HIT is an iatrogenic, prothrombotic, immune-mediated disorder associated with antibodies directed against platelet factor 4 (PF4) and heparin complexes. Once these pathogenic anti-PF4/heparin antibodies develop, they recognize and bind to antigenic complexes formed on cell surfaces composed of PF4 released from platelets bound to cell membrane glycosaminoglycans (GAGs). Unlike platelets, which have only chondroitin sulfate on their surface, endothelial cells express mainly heparan sulfate resulting in a very high capacity to form PF4/GAG complexes and become targets for HIT antibodies. In fact, activation of endothelial cells by HIT antibodies was recognized almost 25 years ago (Cines et. al., 1987). We now show direct interaction of the HIT-like monoclonal antibody KKO with perithrombus endothelial cells, which propagates thrombosis following laser induced cremaster vessel injury in a passive immunization murine model of HIT. PF4 released from activated platelets at the site of laser injury binds rapidly and predominantly to the adjacent endothelium and is recognized by KKO in both transgenic mice expressing only human PF4 (hPF4+) and mice expressing hPF4 and human FcgRIIA on platelets (hPF4+/FcgRIIA+). These studies show that HIT-like antigenic complexes are present within thrombi prior to antibody exposure, predominantly localized to endothelial cells, which is consistent with their surface GAGs having higher affinity for PF4 than platelets. These endothelial cell surface PF4/GAG complexes, and with it KKO binding, are dissociated by high concentrations of intravenous heparin. Infusion of KKO in hPF4+/FcgRIIA+ mice but not in control mice, reinitiates growth of previously stable thrombi at sites of laser injury, leading to a significant increase in vascular occlusion (24/33 injuries, 73%, compared to 0/30 in control mice; P&lt;0.0001). Clot extension is followed by dissemination of endothelial activation, demarcated by binding of annexin V and Factor Xa, and extension of the endothelial surface that binds KKO. Based on these studies, we propose a model of feed-forward rolling recruitment to explain how the endothelial lining contributes to the prothrombotic state in HIT: PF4 released from activated platelets at a site of injury or disease binds to the surface of perithrombus endothelial cells, which then binds HIT antibodies followed by endothelial cell activation. These activated endothelial cells then bind and activate additional platelets, leading to the next round of PF4 release, more extensive endothelial cell activation and platelet recruitment into thrombi. Disclosures: No relevant conflicts of interest to declare.
Precision Medicine for Continuing Phenotype Expansion of Human Genetic Diseases (2015)

Determining the exact genetic causes for a patient and providing definite molecular diagnoses are core elements of precision medicine. Individualized patient care is often limited by our current knowledge of disease etiologies and commonly used phenotypic-based diagnostic approach. The broad and incompletely understood phenotypic spectrum of a disease and various underlying genetic heterogeneity also present extra challenges to our clinical practice. With the rapid adaptation of new sequence technology in clinical setting for diagnostic purpose, phenotypic expansions of disease spectrum are becoming increasingly common. Understanding the underlying molecular mechanisms will help us to integrate genomic information into the workup of individualized patient care and make better clinical decisions.
A Method of Moving Object Tracking Based on Background Subtraction and Color Feature (2013)

Background subtraction method is a tracking method only based on motion information. It cannot make a distinction between the foreground objects detected. The feature-based tracking methods need to select the appropriate prediction and search algorithm. But the algorithm complexity and amount of computation is large for the multi-target tracking. Therefore, this paper presents the method based on the combination of background subtraction and color feature. For improving the weak points of the traditional background subtraction method based on grayscale image, it is proposed to use the background subtraction based on RGB color difference. It improves the integrity of the foreground regions that makes better effect of the color feature matching. The experimental results show that in the multi-target tracking applications, the proposed method is simple and easy to implement. It can be used to track the targets with specific color feature and has high robustness.
MODIFIED WHEAT STARCHES USED AS STABILIZERS IN SET‐STYLE YOGURT (2001)

ABSTRACT Yogurt was formulated with gelatin; native wheat starch (NWS); and modified wheat starches (MWS) (acetylated cross‐linked, hydroxypropylated, or hydroxypropylated cross‐linked). Yogurt samples were evaluated for chemical (fat, total solids, pH, titratable acidity); microbiological (yeasts/molds and lactic acid bacteria); and physical (rheological, textural, color, syneresis) properties during 60 days of refrigerated storage. Yogurt formulated with NWS exhibited a significantly greater storage modulus (G′) and firmness compared with yogurts prepared with MWS. Minimal syneresis was measured in all yogurt samples. The titratable acidity of yogurt samples increased and pH decreased during storage. Yeasts/molds were not detected while lactic acid bacteria counts decreased ∼ 1 log CFU/g by day 60 in all yogurt samples. This study showed that the characteristics of yogurt formulated with NWS and gelatin were similar, so NWS may be used as an alternative stabilizer. The MWS stabilized yogurts were stable but had different consistencies than gelatin‐ and NWS‐stabilized yogurts.
Draft Genome Sequence of Multidrug-Resistant Strain Citrobacter portucalensis MBTC-1222, Isolated from Uziza (Piper guineense) Leaves in Nigeria (2018)

In this work, we report the draft whole-genome sequence of the multiply antibiotic-resistant <i>Citrobacter portucalensis</i> strain MBTC-1222 isolated from the uziza leafy vegetable in Nigeria. Sequence analysis showed the assembled genome size to be 4,881,935 bp, containing 4,603 protein-coding genes, 131 pseudogenes, 7 rRNAs, 74 tRNAs, and 9 noncoding RNAs (ncRNAs).
Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions (2009)

Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic diseases. Oral administration of silibinin inhibited compound 48/80-induced passive cutaneous anaphylaxis-like reaction in mice. Silibinin also attenuated anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-mediated passive systemic and cutaneous anaphylaxis. Silibinin had no cytotoxicity on rat peritoneal mast cells (RPMC). Silibinin dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, silibinin inhibited the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 in RPMC. Pretreatment of silibinin suppressed the antigen-stimulated calcium uptake and activation of nuclear factor-kappa B (NF-kappaB) in RPMC. Furthermore, silibinin increased the intracellular cAMP level. Increased cAMP, decreased calcium uptake and suppressed NF-kappaB activity might be involved in the inhibitory effect of silibinin on the secretory response. Our findings provide possibility that silibinin may serve as an effective therapeutic agent for allergic diseases.
HOXB7 as a Prognostic Factor and Mediator of Colorectal Cancer Progression (2011)

Our findings suggest that HOXB7 protein, as a valuable marker of CRC prognosis, plays an important role in the development and progression of human CRC.
Surgical treatment of common entrapment neuropathies in the upper limbs (2000)

Entrapment neuropathies of the upper extremity are common, debilitating conditions. Most patients with these neuropathies are readily diagnosed on purely clinical grounds and may be effectively managed with nonoperative measures. However, the broad differential diagnosis often necessitates electrodiagnostic testing and radiographic imaging to clarify the situation. This review focuses on three of the most common entrapment neuropathies in the upper limbs: carpal tunnel syndrome (median nerve entrapment at the wrist), cubital tunnel syndrome (ulnar nerve entrapment at the elbow), and radial tunnel syndrome (posterior interosseous nerve entrapment). Anatomical considerations, patient evaluation, indications for surgical intervention, options for surgical approaches, outcomes, and complications are discussed.
Tensile High Strain-Rate Behavior of Reinforcing Steel from an Existing Bridge (2009)

The American Concrete Institute (ACI) is a leading authority and resource worldwide for the development and distribution of consensus-based standards, technical resources, educational programs, certification programs, and proven expertise for individuals and organizations involved in concrete design, construction, and materials, who share a commitment to pursuing the best use of concrete.
Reduction of organic compounds with diborane (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of organic compounds with diboraneClinton F. LaneCite this: Chem. Rev. 1976, 76, 6, 773–799Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/cr60304a005https://doi.org/10.1021/cr60304a005research-articleACS PublicationsRequest reuse permissionsArticle Views4146Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-repetition-rate solid state laser for space communications (1995)

The CNES (Centre National d'Etudes Spatiales, French space agency) established the laser system characteristics for Mars-Earth spatial communications using the Pulse Position Modulation technique. Today, diode-pumped solid-state lasers are under intense research and development. Indeed, in comparison with flash-lamp pumped laser, they offer significant advantages in terms of efficiency, compactness, lifetime and high beam quality. We have demonstrated that gain-switch operation is preferable to Q-switching technique to control and to obtain a good pulse width and amplitude reproducibility. The pulse width requirement and the laser-diode pumping scheme lead to a preferred configuration based on a microchip laser oscillator coupled to an amplifier. Best results were performed with a Nd:YVO<SUB>4</SUB> microchip longitudinally-pumped by fiber-coupled laser-diode bar. Diffraction limited beam, 15 ns pulse width and 100 kHz repetition rate were achieved. The output beam was actually also single frequency and linearly polarized. A transversally-diode-pumped 7-pass amplifier is also demonstrated.
Predictors and treatment response with cardiac resynchronization therapy in patients with heart failure characterized by dyssynchrony: a pre-defined analysis from the CARE-HF trial (2007)

Patients with echocardiographic evidence of more severe cardiac dyssynchrony and low systolic blood pressure obtain greater benefit from CRT, although benefits were substantial across the range of subjects included in the trial.
Impact Behavior of Fiber/Metal Laminates (FMLs) under Low Velocity (2010)

섬유금속 적층판(FMLs)은 손상허용도를 향상시키고 무게를 줄이는데 적합하여 항공우주 응용의 신소재로 각광을 받고 있다. 본 연구에서는 우선 섬유와 알루미늄을 이용하여 적층판을 제조하여 인장시험을 수행 후 FMLs의 기계적 물성을 평가하였다. 또한 알루미늄과 섬유적층의 변화를 주어 낙추충격시험기(Drop Weight Impact Tester)를 이용하여 저속충격하에서 낙추 높이를 조절하여 각 종류의 시험편 마다 충격시간에 따른 하중과 충격흡수에너지를 각각 비교하였다. 추가로 유한요소해석을 이용하여 시험조건과 동일 조건하 인장과 충격거동해석을 수행한 결과를 실험치와 비교하여 실험과 이론해석이 잘 일치함을 보였다. The Fiber/Metal Laminates (FMLs) have been developed as a new composite material for aerospace application to reduce weight and improve damage tolerance. In this study, firstly FMLs were manufactured and the tensile test was performed to investigate the mechanical properties of FMLs. Furthermore, impact behavior of the low velocity on FMLs which consisted of different types of aluminum or fiber/epoxy layers was tested by the drop weight impact tester based on the different impact energy conditions. The load-time and energy-time curves were employed to evaluate the impact performance of different specimens. Moreover, finite element analysis (FEA) was also performed to simulate the tensile test and impact behavior of FMLs under the same conditions with the tests and good agreements have been obtained between the FEA predictions and experimental results.
Early pulmonary response to allergen is attenuated during acute emotional stress in females with asthma (2003)

Some asthma patients and physicians who treat asthma have reported that stress worsens their disease. It has also recently been shown that chronic stressful life events increase airway inflammation 6-24 h after inhalation of antigen in patients with allergic asthma. However, there is no data regarding the effect of an acute stressor on the airway constriction that occurs within minutes of antigen inhalation (early pulmonary response) in this same population. The aim of this study was to examine this effect in eight females with allergic asthma. Each subject was challenged with increasing concentrations of inhaled allergen on a control visit (no stress) and on a stress visit, when they were asked to verbally recount an emotionally stressful situation between each concentration. Systolic (SP) and diastolic (DP) blood pressure, cardiac frequency (fC) and forced expiratory volume in one second (FEV1) were measured on both visits. SP, DP and fC were statistically increased on the stress visit as compared to control. Per cent decrease in FEV1 at the same last dose of allergen was significantly less on the stress visit (11.2 +/- 7.0%) compared to control (15.0 +/- 8.7%). These findings suggest that the early pulmonary response to inhaled allergen is attenuated while verbally re-experiencing an acute emotional stressor in females with allergic asthma.
ChemInform Abstract: Recent Developments in Flavin‐Based Catalysis (2013)

Abstract Review: ca. 66 refs.
Predictable Reliability and Packet Loss Domain Separation for IP Media Delivery (2011)

Internet protocol (IP) based media delivery enables applications such as Voice over IP or, most recently, stereoscopic HD-TV. Suchlike transport of typically time-constrained media between two end-points has a number of important characteristics, both on the transport and content side. We focus on live streams of audio-visual data that are assumed as time-constrained and loss-tolerant. We aim at optimizing IP transport over heterogeneous networks by hybrid and loss domain separated error correction with residual error. Hybrid error correction (HEC) approaches the channel capacity dynamically and achieves predictable reliability and predictable delay (PRPD) when residual loss is tolerable, while loss domain separation applies optimally chosen HEC parameters to individual network segments. In this paper, we apply an atomic HEC coding unit to individual segments of network links between source and sink, and show by analysis and example how redundancy is distributed optimally.
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing (2022)

Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development of targeted therapies. Here, we demonstrate that patients suffering from anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) showed increased levels of cGAMP and enhanced IFN-I signature. To identify disease mechanisms and potential therapeutic targets, we developed a mouse model for pulmonary AAV that mimics severe disease in patients. Immunogenic DNA accumulated during disease onset, triggering cGAS/STING/IRF3-dependent IFN-I release that promoted endothelial damage, pulmonary hemorrhages, and lung dysfunction. Macrophage subsets played dichotomic roles in disease. While recruited monocyte-derived macrophages were major disease drivers by producing most IFN-β, resident alveolar macrophages contributed to tissue homeostasis by clearing red blood cells and limiting infiltration of IFN-β-producing macrophages. Moreover, pharmacological inhibition of STING, IFNAR-I, or its downstream JAK/STAT signaling reduced disease severity and accelerated recovery. Our study unveils the importance of STING/IFN-I axis in promoting pulmonary AAV progression and identifies cellular and molecular targets to ameliorate disease outcomes.
The transition of the trattic mode in sight-seeing areas (1987)

観光地特に自然風景地に俗化等の問題をもたらす主要因の一つである交通機関の変遷を観光との関係から検討し時代区分を行った。その結果, 鉄道による第1期 (明治中期～明治末), 乗合自動車による第2期 (大正時代) 遊覧バス, ケーブルカーによる第3期 (昭和初期～昭和20年代), ロープウェイ, 展望道路による第4期 (昭和30年代), 自家用車, 高速道路による第5期 (昭和40年以降) の5区分を得た。
Advances in Underwater Oil Plume Detection Capabilities (2021)

Historically, visual observation is an emergency responder's first ‘tool’ in identifying spilled oil. Optical detection has since expanded to include a myriad of signals from space, aircraft, drone, vessel and submersible platforms that can provide critical information for decision-making during spill response efforts. Spill monitoring efforts below the air-water interface have been vastly improved by advances with in situ optical sensors and vehicle platform technology. Optical techniques using fluorescence, scattering, and holography offer a means to determine dissolved versus droplet fractions, provide oil concentration estimates and serve as proxies for dispersion efficiency. For subsurface spills over large space and time scales, Autonomous Underwater Vehicles (AUVs) can be used to provide subsurface plume footprints and estimate oil concentrations. For smaller, more frequent spills, tethered compact Remotely Operated Vehicles (ROVs) may be more appropriate as they are easy to deploy for rapid detection. Two underwater oil detection technologies have been developed: (1) A Remote Environmental Monitoring UnitS (REMUS-600) AUV equipped with fluorescence and backscatter SeaOWL UV-A (Oil-in-Water Locator; Sea-Bird Scientific WET Labs Inc.), holographic imager (HoloCam; SeaScan, Inc), hydrographic information, video camera, CTD and a water/oil sampler. (2) A tethered ROV system (DTG2, Deep Trekker Inc.) equipped with video camera, UviLux (Chelsea Technologies Group, Inc) fluorometer, a CTD and water/oil sampler. Calibration and validation tests of the sensor suite were conducted at the Coastal Response Research Center flume tank (NH, USA). Oil concentration estimates were verified by chemical analysis of hydrocarbons and particle size analysis (LISST 200X, Sequoia, Inc). Operational performance of the ROV platform and sensors was evaluated at the Ohmsett wave tank (NJ, USA). Field performance of the REMUS and sensor suite was evaluated at natural seeps near Santa Barbara, CA. This research demonstrates the forensic value of in situ optical data for improved understanding of the behavior and transport of spilled oil below the air-sea interface.
Impact of Preoperative Hematocrit Level on Length of Stay after Surgery on the Lumbar Spine (2015)

Study Design Retrospective case series. Objective Recent studies suggest that baseline hematocrit (Hct) levels may affect the surgical outcomes after orthopedic procedures. The authors examined whether preoperative Hct values had a significant effect on the hospital length of stay (LoS) after lumbar spinal procedures. Methods We retrospectively reviewed patients who underwent routine lumbar spine procedures from November 2012 through September 2013. Patients were included if they had both a baseline Hct and hospital LoS recorded. Patients were divided into two groups: those with an Hct ≥ 40% (nonanemic) and those with an Hct < 40% (anemic). LoS after surgery was evaluated for each group. Results One hundred seventeen patients underwent lumbar spine procedures for lumbar stenosis (n = 34), symptomatic lumbar disk herniation (n = 39), lumbar spondylolisthesis (n = 26), lumbar adjacent segment disease (n = 8), or symptomatic recurrent lumbar disk herniation (n = 10). Mean LoS was 3.3 and 2.4 days in anemic (27 patients) and nonanemic groups (90 patients), respectively (p = 0.02). The linear regression analysis demonstrated that a decrease in Hct was associated with a longer stay. A decrease from preoperative to postoperative day 1 Hct of 3.5 points resulted in an increased LoS of 1 day (R (2) = 0.145; p = 0.002). The correlation of Hct decrease with longer LoS remained (β = 0.167, p = 0.006) after adjusting for other variables with multivariate regression analysis. Conclusions Lower preoperative Hct or a substantial decrease in Hct may contribute to longer hospitalization after lumbar spine surgery. These findings should prompt an investigation into the strategies for optimizing Hct levels in patients with preoperative anemia prior to lumbar spine procedures.
Reactivity of the Acridine Ring: A Review (2004)

Acridine derivatives are potent biological fluorescent probes, as well as anti-microbial, anti-bacterial, anti-tumor, and DNA-binding agents. The acridinic pattern is included in many therapeutic agents, with more than 600 articles published in 2002 alone.
Iterative Joint Channel Estimation and Multiuser Detection for Wireless MIMO-OFDM Systems: Performance in a Real Indoor Scenario (2007)

An iterative receiver for multiple-input multiple- output (MIMO) orthogonal frequency division multiplexing (OFDM) wireless systems is presented and tested on channel measurements from a real indoor scenario. The receiver jointly performs channel estimation and multiuser detection, with soft information iteratively provided by the singleuser decoders. Results for the performance are presented in terms of bit error rate (BER) and relative minimum mean square error (MMSE) vs signal-to-noise ratio (SNR). Comparison with the single-user bound (SUB) shows a loss in performance due to frequency correlation.