gebhart/patrepeval huggingface dataset:
Abstract P6-15-03: Outcome after neoadjuvant chemotherapy in elderly breast cancer patients – a pooled analysis of individual patient data from eight prospectively randomized controlled trials (2018)

Abstract Introduction: Recent studies showed the high and independent impact of age (&amp;lt;40 years) on pathologic complete remission (pCR) and prognosis for patients undergoing neoadjuvant chemotherapy (NACT). Some physicians might not consider elderly patients (&amp;gt;65 years) for NACT due to poor prognosis or higher toxicity. The aim of this analysis is to help selecting appropriately elderly women who would benefit from NACT. Secondly, survival parameters will be investigated in several clinical and histological subgroups. Methods: From 1998 to 2010, eight prospectively randomized German Breast Group (GBG) trials of anthracycline- and taxane-based NACT were performed and analyzed in this study. Results: Compared to the overall average, women older than 65 years had significant larger tumors and more overall lymph node involvement. Also, compared to patients younger than 51 years, they had more lobular invasive tumors. Histologically, they had more G2 tumors, more estrogen-receptor positive tumors. PCR (ypT0 ypN0) was strongly associated with age: &amp;gt;65y: 11.7%; 51-65y: 14.1%; 40-50y: 17.3%; &amp;lt;40y: 20.9%. The multivariable logistic regression analysis of clinical parameters showed that young age, clinical stage T4, invasive ductal cancer and poor differentiated breast cancer are predictive for high pCR. The multivariate analyses of molecular subgroups also showed that age &amp;gt;65years is a predictor of significant (p&amp;lt;0.05) lower pCR in TNBC and HR positive/HER2- breast cancers. Nonetheless, in this cohort, HER2+ patients showed pCR rates as high - and for HR+/HER2+ even higher - pCR rates compared to younger patients. Discussion: This study underlines the unfavorable impact of higher age on pCR, but it shows nevertheless a realistic chance for pCR if NACT is applied - especially for HER2+ patients. Furthermore, elderly patients in this analysis with non-TNBC have a good prognosis (comparable to younger patients) regarding OS, even if they do not have pCR. Citation Format: von Waldenfels G, Loibl S, Furlanetto J, Anna M, Lederer B, Denkert C, Hanusch C, Huober J, Jackisch C, Kümmel S, von Minckwitz G, Schneeweiss A, Untch M, Rhiem K, Fasching PA, Blohmer JU. Outcome after neoadjuvant chemotherapy in elderly breast cancer patients – a pooled analysis of individual patient data from eight prospectively randomized controlled trials [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-15-03.
Supplementary Figures S1 - S6 from <i>MECP2</i> Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy (2023)

&lt;p&gt;Supplementary Figure S1. The Amplification of the MECP2 Gene Drives Its Expression, and the MECP2 Gene on the Active X Chromosome is Preferentially Amplified, Related to Figure 1. Supplementary Figure S2. MECP2 Overexpression Allows Soft Agar Growth of N minus RAS Cells in Two Different Types of Human Breast Epithelial Cells, and MECP2 Splicing Isoforms Differ In Their Ability to Confer Anchorage Independent Growth, Related to Figure 2A. Supplementary Figure S3: MECP2 Overexpression Allows Two Different Types of N minus RAS Breast Epithelial Cells To Grow As Tumor Xenograft In Nude Mice, Related to Figure 2E, 2F. Supplementary Figure S4. The MECP2 e2 Short Splicing Isoform Allows Sustained Activation of the MAPK Pathway after Prolonged Starvation in Minimal Medium without Growth Factors, Related to Figure 4A-C. Supplementary Figure S5. Both MECP2 Isoforms Activate the PI3K Pathway, Related to Figure 4D. Supplementary Figure S6. Additional human cancer cell lines with high level of MECP2 are growth-inhibited upon inhibition of MECP2 expression, Related to Figure 4E.&lt;/p&gt;
Coronary artery revascularization without cardiopulmonary bypass. (1984)

At the Texas Heart Institute between October 1969 and August 1983, there were 191 single bypass procedures performed without pump oxygenator support. These cases have been divided into two groups: Group I (160 patients) represents the time period from October 1969 through December 1981 and includes our experience with single vessel left anterior descending (LAD) coronary artery bypass without pump oxygenator support; Group II (31 patients) represents the period between January 1982 and August 1983 and includes our initial operative experience in patients with failed percutaneous transluminal coronary angioplasty (PTCA). Of 145 primary operations in Group I patients, 113 were single bypasses to the right coronary artery with a postoperative infarction rate of 3.5% (4/113). Single bypass to the left anterior descending (LAD) coronary artery in 32 patients who underwent operation early in the series was associated with a postoperative infarction rate of 18.7% (6/32) and is no longer performed without pump oxygenator support. Fifteen patients had previous coronary bypass operations and underwent single bypass without pump as a second procedure. Postoperative infarction rate in this redo group was 6.6% (1/15). Long-term follow-up data was obtained on all patients from 1 to 11 years after surgery (mean follow-up, 4 years). Four late cardiac deaths occurred at 2,3,4 and 7 years in the primary operation group (3.5%) 4/113. One late death occurred at 7 years in the redo group (6.6%) 1/15. In Group II, failed PTCA accounted for 39% of the 31 patients who underwent single right bypass without pump support; there were no perioperative infarctions and one death. Coronary bypass can be safely and effectively employed without pump oxygenator support if performed expeditiously and limited to right coronary lesions which have an adequate distal vessel. This technique has become more useful with the advent of attempted PTCA for single coronary lesions.
Supersonic cluster beams of III–V semiconductors: GaxAsy (1986)

Supersonic beams of semiconductor clusters with the formula GaxAsy were generated by laser vaporization of a disc of pure GaAs mounted on the side of a pulsed supersonic nozzle. These cluster beams were characterized by laser photoionization with various fixed-frequency lasers followed by time-of-flight mass spectrometry. Mass analysis of the clusters with x+y&amp;gt;10 showed all clusters in the composition range from Gax+y through GaxAsy to Asx+y to be present in roughly the amount expected from a binomial distribution. In the smaller clusters strong variations were observed from this expected binomial distirbution as a result of kinetic effects in the cluster formation process. Photoionization with an ArF excimer laser at very low pulse energy revealed a pronounced even/odd alternation in the photoionization cross section of the GaxAsy clusters, depending only on the total number of atoms in the cluster. Clusters in the 5–21 atom range with an odd number of atoms were one-photon ionized by the 6.4 eV ArF excimer laser photons. This even/odd alternation in ionization properties of the clusters supports the view that the even clusters have fully paired singlet ground states with no dangling bonds. At higher ArF excimer laser fluences, the observed mass spectrum became increasingly affected by fragmentation. As is true with bulk GaAs surfaces, these GaxAsy clusters evaporate largely by the loss of arsenic (probably As2) when heated by the laser, leaving behind clusters which are richer in gallium.
Quality of Life following Stereotactic Radiosurgery for Single and Multiple Brain Metastases (2017)

Among patients with brain metastasis, QOL preservation must remain paramount as multimodality therapy continues to improve. In the present investigation, 12-month QOL preservation was 79%. However, patients with more than 3 brain metastases were at significantly greater risk for QOL decline.
An Essential Role of the CAAT/Enhancer Binding Protein-α in the Vitamin D-Induced Expression of the Human Steroid/Bile Acid-Sulfotransferase (SULT2A1) (2005)

The vitamin D receptor (VDR) regulates steroid and drug metabolism by inducing the genes encoding phase I and phase II enzymes. SULT2A1 is a liver- and intestine-expressed sulfo-conjugating enzyme that converts the alcohol-OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites. 1alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces SULT2A1 gene transcription after the recruitment of VDR to the vitamin D-responsive chromatin region of SULT2A1. A composite element in human SULT2A1 directs the 1,25-(OH)2D3-mediated induction of natural and heterologous promoters. This element combines a VDR/retinoid X receptor-alpha-binding site [vitamin D response element (VDRE)], which is an imperfect inverted repeat 2 of AGCTCA, and a CAAT/enhancer binding protein (C/EBP)-binding site located 9 bp downstream to VDRE. The binding sites were identified by EMSA, antibody supershift, and deoxyribonuclease I footprinting. C/EBP-alpha at the composite element plays an essential role in the VDR regulation of SULT2A1, because 1) induction was lost for promoters with inactivating mutations at the VDRE or C/EBP element; 2) SULT2A1 induction by 1,25-(OH)2D3 in C/EBP-alpha-deficient cells required the expression of cotransfected C/EBP-alpha; and 3) C/EBP-beta did not substitute for C/EBP-alpha in this regulation. VDR and C/EBP-alpha were recruited concurrently to the composite element along with the coactivators p300, steroid receptor coactivator 1 (SRC-1), and SRC-2, but not SRC-3. VDR and C/EBP-alpha associated endogenously as a DNA-dependent, coimmunoprecipitable complex, which was detected at a markedly higher level in 1,25-(OH)2D3-treated cells. These results provide the first example of the essential role of the interaction in cis between C/EBP-alpha and VDR in directing 1,25-(OH)2D3-induced expression of a VDR target gene.
Prostaglandin E2 Regulates Renal Cell Carcinoma Invasion through the EP4 Receptor-Rap GTPase Signal Transduction Pathway (2011)

Prognosis for patients with early stage kidney cancer has improved, but the treatment options for patients with locally advanced disease and metastasis remain few. Understanding the molecular mechanisms that regulate invasion and metastasis is critical for developing successful therapies to treat these patients. Proinflammatory prostaglandin E(2) plays an important role in cancer initiation and progression via activation of cognate EP receptors that belong to the superfamily of G protein-coupled receptors. Here we report that prostaglandin E(2) promotes renal cancer cell invasion through a signal transduction pathway that encompasses EP4 and small GTPase Rap. Inactivation of Rap signaling with Rap1GAP, like inhibition of EP4 signaling with ligand antagonist or knockdown with shRNA, reduces the kidney cancer cell invasion. Human kidney cells evidence increased EP4 and decreased Rap1GAP expression levels in the malignant compared with benign samples. These results support the idea that targeted inhibition of EP4 signaling and restoration of Rap1GAP expression constitute a new strategy to control kidney cancer progression.
Molecular Mechanisms of agr Quorum Sensing in Virulent Staphylococci (2007)

How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.
Treatment of Alumina and Silica Chemical Mechanical Polishing Waste by Electrodecantation and Electrocoagulation (1999)

Electrocoagulation and electrodecantation were investigated as methods to concentrate solids from the dilute suspensions typically encountered as waste streams of chemical mechanical polishing operations. Model silica and alumina suspensions containing particles of approximately 200 nm in diameter were studied. 3 L batches of suspension were subjected to electric fields of several volts per centimeter and monitored for particle removal. Electrodecantation was shown to clarify charge stabilized, low conductivity suspensions (20 mS/cm) without modifying the mean particle size or surface/charge characteristics. The technique is thus suited to circumstances where recycle and reuse of particles is desirable, though the results also show that Joule heating may disrupt the decantation process and so must be controlled in order to apply the method to higher conductivity suspensions. Electrocoagulation was shown to effectively destabilize and clarify high conductivity suspensions (1300 μS/cm), producing aggregates several‐fold larger than the primary particle size, which subsequently sedimented from suspension. Intermittent application of the electric field was found to yield superior rates of particle removal while consuming substantially less electrical power (ca. 1 Wh/L of clear solution). © 1999 The Electrochemical Society. All rights reserved.
Ascertaining cells’ synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries (2022)

Brain function depends on synaptic connections between specific neuron types, yet systematic descriptions of synaptic networks and their molecular properties are not readily available. Here, we introduce SBARRO (Synaptic Barcode Analysis by Retrograde Rabies ReadOut), a method that uses single-cell RNA sequencing to reveal directional, monosynaptic relationships based on the paths of a barcoded rabies virus from its "starter" postsynaptic cell to that cell's presynaptic partners. Thousands of these partner relationships can be ascertained in a single experiment, alongside genome-wide RNAs. We use SBARRO to describe synaptic networks formed by diverse mouse brain cell types in vitro, finding that different cell types have presynaptic networks with differences in average size and cell type composition. Patterns of RNA expression suggest that functioning synapses are critical for rabies virus uptake. By tracking individual rabies clones across cells, SBARRO offers new opportunities to map the synaptic organization of neural circuits.
Introducing New Profiles for Broadcast Applications in the JPEG 2000 International Recommendation | Standard (2010)

The ITU recently added new profiles to the JPEG 2000 standard for broadcast video contribution and distribution within the production flow published ITU-T Rec. T.800 (08/2002)/Amd.4 (2010E), an amendment to JPEG 2000 core coding system. This amendment represents a major step toward a transport system for studio contribution allowing equipment from different manufacturers to interoperate. The process relies on both existing standards and new amendments from three international standard organizations JPEG, MPEG and SMPTE developed in cooperation with studios, broadcasters and equipment vendors. — The new amendment specifies a selection of encoding parameters and newly defines rate limits over seven operating levels for video encoded with JPEG 2000. The operating levels create a basis for compliance test points to ensure equipment interoperability. The paper also reviews a proposed transport mechanism for the codestream over SDI and IP.
Early mortality in bone marrow transplantation for acute lymphocytic leukaemia a multivariate analysis of risk factors. (1994)

In our patients and within the range of treatment variables studied, age, Karnofsky index, and graft-versus-host disease are the most important factors related with early mortality.
Immunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes (2022)

ABSTRACT Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic resistance no clinically approved vaccine against Listeria is available. Attenuated Listeria strains offer protection and are tested as antitumor vaccine vectors, but would benefit from a better knowledge on immunodominant vector antigens. To identify novel antigens, we screened for Listeria epitopes presented on the surface of infected human cell lines by mass spectrometry-based immunopeptidomics. In between more than 15,000 human self-peptides, we detected 68 Listeria epitopes from 42 different bacterial proteins, including several known antigens. Peptide epitopes presented on different cell lines were often derived from the same bacterial surface proteins, classifying these antigens as potential vaccine candidates. Encoding these highly presented antigens in lipid nanoparticle mRNA vaccine formulations resulted in specific CD8+ T-cell responses and high levels of protection in vaccination challenge experiments in mice. Our results pave the way for the development of a clinical mRNA vaccine against Listeria and aid to improve attenuated Listeria vaccines and vectors, demonstrating the power of immunopeptidomics for next-generation bacterial vaccine development.
Epidemiologic Modeling of HIV/AIDS: Use of Computational Models to Study the Population Dynamics of the Disease to Assess Effective Intervention Strategies for Decision-making. (2008)

Computational models and simulations are becoming central research tools in epidemiology, biology, and other fields. Epidemiologic research involves the study of a complex set of host, environment and causative agent factors as these interact to impact health and diseases in any population. The most advanced of these efforts have focused on micro (cellular) or macro (human) population levels. The dynamic interplay of HIV with a focus in its hosts at the cellular level provides the micro-epidemiologic basis, while the dynamic interplay of multifactorial determinants: biomedical, behavioral, and socioeconomic factors provide the macro-epidemiologic basis at the human population level. We have developed the computational tools and mathematical approaches to study the population-level effects of various drugs on HIV to integrate models from micro to macro- levels in a seamless fashion. The critical variables that facilitate transmission of HIV and intracellular interactions and molecular kinetics were considered. Such multilevel models are essential if we are to develop quantitative, predictive models of complex biological systems such as HIV/AIDS.
Efficient frequency noise reduction of GaAlAs semiconductor lasers by optical feedback from an external high-finesse resonator (1989)

The reduction of frequency noise power level of non-antireflection-coated GaAlAs laser diodes by several orders of magnitude using optical feedback from an external high-finesse Fabry-Perot resonator is discussed. Optimum oscillation parameters were derived from a steady-state model. Long-term performance was obtained by electronic feedback phase control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A design and prototyping of an object-oriented program debugger (1997)

This paper introduces our design and prototyping of a debugger for an object-oriented programming language -Object-Oriented CHILL. CHILL is a high level language recommended by CCITT(ITU-T). CHILL has been extended to Object-Oriented CHILL for adoption of object-orientedness.
Determination of bisphenol A and impurities by gas chromatography of their trimethylsilyl ether derivatives (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of bisphenol A and impurities by gas chromatography of their trimethylsilyl ether derivativesLaurence E. BrydiaCite this: Anal. Chem. 1968, 40, 14, 2212–2215Publication Date (Print):December 1, 1968Publication History Published online1 May 2002Published inissue 1 December 1968https://pubs.acs.org/doi/10.1021/ac50158a057https://doi.org/10.1021/ac50158a057research-articleACS PublicationsRequest reuse permissionsArticle Views430Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Psychophysical measurement of night vision goggle noise (2003)

Pilots, developers, and other users of night-vision goggles (NVGs) have pointed out that different NVG image intensifier tubes have different subjective noise characteristics. Currently, no good model of the visual impact of NVG noise exists. Because it is very difficult to objectively measure the noise of a NVG, a method for assessing noise subjectively using simple psychophysical procedures was developed. This paper discusses the use of a computer program to generate noise images similar to what an observer sees through an NVG, based on filtered white noise. The images generated were based on 1/f (where f is frequency) filtered white noise with several adjustable parameters. Adjusting each of these parameters varied different characteristics of the noise. This paper discusses a study where observers compared the computer-generated noise images to true NVG noise and were asked to determine which computer-generated image was the best representation of the true noise. This method was repeated with different types of NVGs and at different luminance levels to study what NVG parameters cause variations in NVG noise.
A Novel Schlemm’s Canal Scaffold (2013)

The Hydrus Microstent was associated with minimal inflammation in both NHP and rabbit eyes with extended follow-up. These preclinical studies demonstrate that the Hydrus Microstent appears to have excellent long-term biocompatibility.
Probabilistic deductive databases (1994)

Knowledge-base (KB) systems must typically deal with imperfection in knowledge, e.g. in the form of imcompleteness, inconsistency, uncertainty, to name a few. Currently KB system development is mainly based on the expert system technology. Expert systems, through their support for rule-based programming, uncertainty, etc., offer a convenient framework for KB system development. But they require the user to be well versed with the low level details of system implementation. The manner in which uncertainty is handled has little mathematical basis. There is no decent notion of query optimization, forcing the user to take the responsibility for an efficient implementation of the KB system. We contend KB system development can and should take advantage of the deductive database technology, which overcomes most of the above limitations. An important problem here is to extend deductive databases into providing a systematic basis for rule-based programming with imperfect knowledge. In this paper, we are interested in an exension handling probabilistic knowledge.