gebhart/patrepeval huggingface dataset:
VALIDATION OF A BRACHIAL OSCILLOMETRY AND MODEL-BASED ESTIMATE OF STROKE VOLUME AGAINST MAGNETIC RESONANCE IMAGING (2018)

Objective: Technological progress recently facilitated 24 hour measurement of central blood pressure and pulsatile hemodynamics, using brachial blood pressure cuffs and dedicated software. A complementary estimate of cardiac function is desirable. Design and method: Our proposed method mathematically describes left ventricular outflow during systole according to a given pressure wave. The model combines a modified 3-element like Windkessel system and transmission line theory, and provides an estimate of stroke volume (SV). For this study, pulse waves, recorded with a brachial cuff at the level of diastolic blood pressure, are utilized. In 97 patients with reperfused acute myocardial infarction and in 2 healthy controls, cardiac magnetic resonance imaging (CMRI; 1.5 Tesla Magnetom, Siemens, Germany) was performed, and SV was measured with standard protocols from short axis cine images (11 slices). Images were acquired using breath hold, retrospective ECG triggered TrueFISP bright blood sequences, and evaluated with standard software (ARGUS, Siemens, Erlangen, Germany). SV from both methods were compared with Pearson[Combining Acute Accent]s correlation coefficients and Bland Altman Plots. Results: Mean age of participants was 56.8 years, 21 were women, 56 smokers, mean nt-proBNP was 1350 pg/ml, mean EF 54% (range 28–76). MRI-derived SV was 76 ml (range 28.5–122), oscillometric device-derived SV was 67 ml (range 35–113). Both SVs was moderately correlated (r = 0.54 (CI 0.39–0.67), p < 0.001). Using the method of Bland-Altman, mean difference between both methods was 8.7 ml (1.96 limits of agreement were 36.7 and −19.3 ml), with no systematic bias - Figure. Both MRI-based and oscillometric method-based SV were inversely related to nt-proBNP levels (r = −0.31, p = 0.002 and r = −0.25, p = 0.01, respectively). Conclusions: Brachial oscillometry and mathematical modeling provide a reasonable estimate of stroke volume, which may be a useful addition to 24 hour measurements of blood pressure and pulsatile hemodynamics.
Optically transparent IR reflective heat mirror films of ZNS-AG-ZNS (1989)

Optically transparent heat mirror films, reflective in the infrared, have been produced based on a dielectric - metal - dielectric design using zinc sulfide and silver coatings. Filters exhibit 87% peak transmission in the visible region, while reflecting 80%. in the infrared. Thermal testing indicated the that the layer filters were unstable to treatments above 300 F. Incorporation of thin barrier coatings of magnesium fluoride between the silver and zinc sulfide lavers produced filters with thermal stability to 700 F while retaining optical characteristics of the three laver svstem. These optical and thermal properties offer possible application for the heat mirror films in tungsten source efficiency improvement applications.
On Performance Estimation in Automatic Algorithm Configuration (2020)

Over the last decade, research on automated parameter tuning, often referred to as automatic algorithm configuration (AAC), has made significant progress. Although the usefulness of such tools has been widely recognized in real world applications, the theoretical foundations of AAC are still very weak. This paper addresses this gap by studying the performance estimation problem in AAC. More specifically, this paper first proves the universal best performance estimator in a practical setting, and then establishes theoretical bounds on the estimation error, i.e., the difference between the training performance and the true performance for a parameter configuration, considering finite and infinite configuration spaces respectively. These findings were verified in extensive experiments conducted on four algorithm configuration scenarios involving different problem domains. Moreover, insights for enhancing existing AAC methods are also identified.
Long-Term Follow-Up of Patients after Autologous Bone Marrow Cell Infusion for Decompensated Liver Cirrhosis (2017)

Although several human clinical trials using various bone marrow-derived cell types for cirrhotic or decompensated patients have reported a short-term benefit, long-term follow-up data are limited. We analyzed the long-term clinical outcomes of autologous bone marrow cell infusion (ABMI) for decompensated liver cirrhosis (LC). Patients enrolled in a pilot single-armed ABMI study were followed up more than 5 years. Bone marrow-derived mononuclear cells (BM-MNCs) from decompensated LC were harvested and after processing were infused into a peripheral vein. The laboratory test results and long-term clinical course including liver transplantation (LT), development of cancer, cause of death, and survival after ABMI were analyzed. Nineteen patients were followed up for a median of 66 months after ABMI. Liver function, including serum levels of albumin and Child-Pugh (CP) score, was improved at the 1-year follow-up. Liver volume was significantly greater, cirrhosis was sustained, and collagen content was decreased at the 6-month follow-up. Five years after ABMI, five patients (26.3%) maintained CP class A without LT or death, and five patients (26.3%) had undergone elective LT. Hepatocellular carcinoma (HCC) occurred in five patients (26.3%), and lymphoma and colon cancer occurred in one patient each. Three patients (15.8%) were lost to follow-up at months 22, 31, and 33, respectively, but maintained CP class A until their last follow-up. Five patients expired due to infection. While improved liver function was maintained in some patients for more than 5 years after ABMI, other patients developed HCC. Further studies of long-term follow-up cohorts after cell therapy for LC are warranted.
Spiers Memorial Lecture. State-resolved studies of unimolecular reactions (1995)

During the last decade, the development of molecular beam and laser technologies has permitted a look into the transition-state region at the dynamics of chemical bond formation and breaking. State-selective preparation of reactants and state-resolved detection of products permits an exacting quantitative test of dynamical theories that are based on accurate ab initio potentials. The control of reaction rate and energy release to products by vibrations at the transition state is illustrated for ketene fragmentation over a simple barrier to yield triplet methylene and carbon monoxide. The barrier to exchange of carbon atoms in ketene has a shallow well at its top; this causes quantum dynamical resonances for motion along the reaction coordinate which are seen as peaks in the isomerization rate constant as a function of energy. For dissociation to singlet methylene and carbon monoxide, there is no barrier to the reverse reaction. The reaction rate is controlled by a variational transition state which tightens as energy increases. The transition state is defined on a separate vibrationally adiabatic potential-energy surface for each product vibrational state. The dynamics of energy flow between transition state and separated fragments are in the strongly coupled limit near threshold (0–200 cm–1). For higher energies the methylene rotations are significantly colder than predicted statistically and thus the dynamics must be partially adiabatic.
Preferences for Web-Based Information Material for Low Back Pain: Qualitative Interview Study on People Consulting a General Practitioner (2018)

This study identified important issues to consider when developing and supplementing existing general practice treatment with Web-based information and advice for patients with LBP. Development of a Web app should consider patient input, and developers should carefully address the following domains: readability, customization, design, credibility, and usability.
Combined genotype and haplotype tests for region-based association studies (2013)

Based on a theoretical model, population genetics simulations and analysis of a central corneal thickness (CCT) Genome Wide Association Study (GWAS) data set we have shown that combined genotype and haplotype approach has a high potential utility for applications in association studies.
367 SUSCEPTIBILITY WEIGHTED IMAGING: VALIDATION OF AN INNOVATIVE MAGNETIC RESONANCE IMAGING TECHNIQUE FOR MEASURING BRAIN IRON. (2006)

<h3></h3> Although iron perturbations have long been connected to Alzheimer9s disease (AD) (Connor et al, 1992; Robinson et al, 1995) their possible role is still very much unclear. To assess whether disruption of iron metabolism is indeed one of the primary events leading to AD or is just a bystander, new techniques are necessary that can sensitively measure levels of steady-state brain iron in patients. One such technique is susceptibility weighted imaging (SWI) where local phase differences are used to map brain iron. Phase and T2 prime do not suffer from reversibility effects that nullify iron signals and are thus superior to standard T2 sequences. The advantages of SWI over conventional MR sequences for iron detection have been described (Haacke et al, 2004; Haacke et al, 2005). To further validate this technique a mouse brain dissection protocol has been developed that enables us to dissect 24 distinct regions of the mouse brain. Furthermore, iron extraction methods from Nelson et al (2000) have been adapted to allow extraction of loosely bound iron (iron bound to phosphate esters, carbohydrates, and organic acids), non-heme bound iron (iron not bound to heme and heme-like structures), and total iron from these brain regions. Iron content was then measured using graphite furnace atomic absorption spectroscopy (GFAAS). Variation in the iron content between brain regions has been found. To preserve most of the loosely bound iron pool microwave irradiation has been used to euthanize animals. IRP-2 knockout mice, which have been shown to accumulate higher iron levels in the brain (LaVaute et al, 2001), are being compared to age matched wild-type mice in this study. IRP-2 regulates intracellular iron metabolism by binding to iron response elements (IRE) located at the 5′ or 3′ UTR of mRNA of proteins responsible for the intake and storage of iron in the cell and thereby stabilizing the respective mRNA or blocking its translation. Results have shown that the methodology and use of the IRP-2 knockout mouse model are valid ways to quantitate brain iron content in vivo.
Composite Material Property Nondestructive Characterization Using Obliquely Insonified Ultrasonic Waves (1994)

The analysis of reflected ultrasonic waves induced by oblique insonification of composite materials is a powerful tool for providing information about defects and material properties. A device was developed to manipulate a pair of transmitting and receiving transducers at various angles of wave incidence and propagation with the fiber orientation. The device was designed as a C-scan attachment to allow inspection at specific locations as well as to obtain global information about the laminates by scanning them, Ultrasonic reflections from composite laminates are acquired and analyzed by a personal computer at high speed, in a transient or spectral form. Graphite/epoxy laminates were tested and the experimental results accurately corroborated the analysis of the wave behavior for tone-burst and pulse results. The inversion algorithm allows the determination of the material elastic constants as well as evaluation of various defects characteristics. The data repeatability and accuracy are very high, making oblique insonification methods easy to standardize for practical applications. This paper reviews the theoretical and experimental progress and examples of application to NDE of composites.
Computational Engine Structural Analysis (1986)

A significant research activity at the NASA Lewis Research Center is the computational simulation of complex multidisciplinary engine structural problems. This simulation is performed using computational engine structural analysis (CESA) which consists of integrated multidisciplinary computer codes in conjunction with computer post-processing for “problem-specific” application. A variety of the computational simulations of specific cases are described in some detail in this paper. These case studies include (1) aeroelastic behavior of bladed rotors, (2) high velocity impact of fan blades, (3) blade-loss transient response, (4) rotor/stator/squeeze-film/bearing interaction, (5) blade-fragment/rotor-burst containment, and (6) structural behavior of advanced swept turboprops. These representative case studies were selected to demonstrate the breadth of the problems analyzed and the role of the computer including post-processing and graphical display of voluminous output data.
Polarimetry: measurements, error analysis, and application (2005)

A simple polarimeter based upon a quarter wave plate and a polarizer is presented. Rotating the quarter wave plate all Stokes vector components are calculated by processing the intensity variation. The effect of misalignment in the linear polarizer azimuth and the deviation from the &#960;/2 retardance of the quarter wave plate is analytical and experimental investigated. The technique is consolidated by using two algorithms for Stokes vector calculation.
The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis (2011)

Exosomes are endosome-derived, 30-100 nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. These different effects of tumor-derived exosomes contribute to the pathogenesis of cancer. This review will discuss the roles of tumor-derived exosomes in cancer pathogenesis, therapy, and diagnostics.
A 64 mW High Picture Quality H.264/MPEG-4 Video Codec IP for HD Mobile Applications in 90 nm CMOS (2008)

We have developed an H.264/MPEG-4 dual video codec IP for mobile applications such as digital still cameras (DSCs), digital video cameras (DVCs), and mobile phones. The codec is capable of encoding and decoding HD-sized moving pictures (1280 pixels by 720 lines at 30 fps) in real-time at an operating frequency of 144 MHz, and SD-sized pictures at 54 MHz. We have implemented our original architecture based on a macroblock-level pipeline method and encoding algorithms suitable for the architecture in the codec, which enable low power of 64 mW for HD encoding with high picture quality equivalent to that of the H.264 reference encoder ldquoJM (Joint Model)rdquo.
Differential susceptibility of successive stages of the somatosensory pathway to isoflurane anaesthesia (2001)

s and Programme: European Society of Anaesthesiologists; 9th Annual Meeting with the Swedish Society of Anaesthesiology; Gothenburg, Sweden, 7-10 April 2001: Neurosciences: Monitoring Equipment and Computers
Keishibukuryogan is not carcinogenic in Sprague-Dawley rats (2016)

Keishibukuryogan is a traditional Japanese medicine widely administered to patients with menopausal symptoms. Because humans use it on a long-term basis, we believed that a carcinogenicity study was warranted. We orally administered keishibukuryogan (TJ-25) extract powder to 6-week-old Sprague-Dawley rats [Crl:CD(SD)], which were divided into four dosage groups-0 (water for injection), 100, 500 and 2,500 mg/kg/day for 24 months. We found that TJ-25 did not affect the survival rate of either sex. Furthermore, it did not affect the clinical condition of the rats, number of superficial tumors found by palpation, body weight, food consumption, hematology, or gross pathological findings. The severity of degeneration of muscle fiber in the femoral skeletal muscle increased slightly in males and females in the 2,500 mg/kg/day group, but TJ-25 did not increase the number of tumors found on histopathological examination. In our study, oral administration of TJ-25 extract powder in rats for 24 months was not associated with an increased incidence of tumors.
Isolation of Tryptophan as an Inhibitor of Ovalbumin Permeation and Analysis of Its Suppressive Effect on Oral Sensitization (2004)

Tryptophan was isolated from rat feces as an active compound against ovalbumin permeation in an in vitro Caco-2 cell model. Tryptophan dose-dependently inhibited ovalbumin permeation with accompanying increase in transepithelial electric resistance, and its inhibitory activity reached a plateau at 10 mM. Brown Norway rats were sensitized by intragastric administration of ovalbumin together with or without tryptophan. Antibody levels specific to ovalbumin in the sera and proliferative responses of spleen mononuclear cells to ovalbumin were significantly lower in rats administered ovalbumin plus tryptophan than those administered ovalbumin alone. These results suggest that tryptophan suppresses oral sensitization to ovalbumin, probably via suppression of ovalbumin absorption from the intestinal tract.
Open Shop Scheduling to Minimize Finish Time (1976)

A linear time algorithm to obtain a minimum finish time schedule for the two-processor open shop together with a polynomial time algorithm to obtain a minimum finish time preemptive schedule for open shops with more than two processors are obtained. It is also shown that the problem of obtaining minimum finish time nonpreemptive schedules when the open shop has more than two processors is NP-complete.
Techno-economic Assessment of SNG-Ethanol Co-production (Bio SNG-Ethanol) via Thermochemical Conversion of Biomass by Indirectly Heated CFB gasifier (2011)

In last years the production of biofuels has generated a high interest because of governments’ actions to reduce fossil fuels consumption in transport and other uses. The aim of this work is the economic analysis of the co­production of synthetic natural gas (SNG) and bioethanol in a biorefinery context. Conceptual process design and techno­economic assessment of a plant size of 2140 dry tonne/day of wood chip (500 MWth) is presented. The proposed Bio SNG­Ethanol process involves biomass gasification (atmospheric indirectly heated CFB gasifier), gas cleaning and conditioning, ethanol synthesis (Rh­based catalyst), ethanol separation and dehydration, methanation (Haldor Topsoe TREMP®) and SNG conditioning. The Bio SNG­Ethanol process is rigorously modeled in a commercial chemical process simulator and the results from the simulations are used to estimate cost of production of synthetic natural gas and bioethanol. The results reveal that a minimum SNG selling price of 37.9 €2010/MWhSNG for a 10% rate of return when an ethanol market price of 0.48 €2010/L and a biomass price of 51 €2010/dry tonne are considered.
High EMI immunity CMOS opamp: design and measurements (2004)

In this paper, a new approach to design a CMOS operational amplifier is presented which provides a good trade-off between high gain and strong immunity to electromagnetic interferences. The proposed amplifier is based on two main blocks: the first is a fully differential folded cascode amplifier with modified differential input pair and the second is a source cross coupled AB class buffer. Thanks to the folded cascade stage and to the symmetrical output buffer, the amplifier exhibits both intrinsic robustness to interferences and good amplifier performances. The circuit was fabricated in a 0.8/spl mu/m n-well CMOS technology (AMS CYE process). Experimental results, in terms of EMI immunity, are presented and successfully compared to commercial amplifiers. Measurements carried out on the chip and the amplifier overall performances are provided along with the corresponding simulation results.
M15382: A fast simulation of RVC MPEG4 SP decoder using Cal2C code generation (2008)

ISO/IEC JTC1/SC29/WG11, 84th MPEG Meeting Document Register, Archamps (France)
The value of FDG‐PET in the staging of gastric adenocarcinoma: A single institution retrospective review (2016)

Our findings support the use of FDG-PET as a valuable adjunct to CT in the staging of GA, as it changed the stage in 48 (28.9%) patients. J. Surg. Oncol. 2016;113:640-646. © 2016 Wiley Periodicals, Inc.
Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration (2017)

Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood. In addition to a direct effect on leukocyte transmigration, we show that laminin 511 affects endothelial barrier function by stabilizing VE-cadherin at junctions and downregulating expression of CD99L2, correlating with reduced neutrophil extravasation. Binding of endothelial cells to laminin 511, but not laminin 411 or non-endothelial laminin 111, enhanced transendothelial cell electrical resistance (TEER) and inhibited neutrophil transmigration. Data suggest that endothelial adhesion to laminin 511 via β1 and β3 integrins mediates RhoA-induced VE-cadherin localization to cell-cell borders, and while CD99L2 downregulation requires integrin β1, it is RhoA-independent. Our data demonstrate that molecular information provided by basement membrane laminin 511 affects leukocyte extravasation both directly and indirectly by modulating endothelial barrier properties.
Reversible malabsorption caused by methyldopa. (1977)

Reversible malabsorption caused by methyldopaWe report a case in which a reversible histological abnormality of the small bowel with features of malabsorption was found to be related to treatment with methyldopa. Case reportA man aged 58 years presented with a short history of diabetes mellitus, and after a right-sided hemiparesis he was found to be hypertensive.After 12 months' treatment with a thiazide diuretic, methyldopa 250 mg thrice daily was added to the regimen.Six months later he was admitted to hospital
Accurate modeling of noise in switched-C /spl Delta//spl Sigma/ analog-to-digital converters (2005)

An accurate physical model of switched-capacitor /spl Delta//spl Sigma/ analog-to-digital converters (ADCs) noise is presented. Noise artifacts for various ADC blocks are captured using simple equations. Model is verified against measured 0.25-/spl mu/m high dynamic range ADC test chip for a wireless receiver. Design guidelines based on the proposed model are discussed.
Self-Assembled Silane Monolayers:  Fabrication with Nanoscale Uniformity (2005)

Illustrating direct connections between surface chemical events and mechanical and topological characteristics of self-assembled monolayers derived from octadecyltrichlorosilane (OTS) adsorption on Si(100), layers prepared in the presence and absence of moisture have been characterized. Uniform and robust self-assembled monolayers are demonstrated provided the Si(100) surface is fully hydroxylated by treatment in piranha solution and the dried surface is exposed to OTS under strict anhydrous conditions. With nanoscale resolution, the uniform mechanical properties are confirmed by interfacial force microscopy while the uniform topological properties are evident in atomic force microscopy images. The monolayer character of the OTS coverage is confirmed by X-ray photoelectron spectroscopy, ellipsometry, and patterning experiments. Analogous surfaces, prepared in the presence of moisture, exhibit nonuniform topological and mechanical properties.