gebhart/patrepeval huggingface dataset:
The structure of the fluorescent adduct formed in the reaction of o-phthalaldehyde and thiols with amines (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe structure of the fluorescent adduct formed in the reaction of o-phthalaldehyde and thiols with aminesS. Stoney Simons Jr. and David F. JohnsonCite this: J. Am. Chem. Soc. 1976, 98, 22, 7098–7099Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/ja00438a070https://doi.org/10.1021/ja00438a070research-articleACS PublicationsRequest reuse permissionsArticle Views780Altmetric-Citations215LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Haptotropic rearrangements in naphthalene-chromium tricarbonyl complexes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHaptotropic rearrangements in naphthalene-chromium tricarbonyl complexesRein U. Kirss and Paul M. TreichelCite this: J. Am. Chem. Soc. 1986, 108, 4, 853–855Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/ja00264a057https://doi.org/10.1021/ja00264a057research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direction estimation of uncorrelated and coherent narrowband signals with uniform linear array (2011)

In this paper, an effective direction-of-arrival (DOA) estimation method is proposed with a uniform linear array (ULA) when uncorrelated and coherent signals coexist. The direction-of-arrivals (DOAs) of uncorrelated signals and coherent signals are estimated in two steps. The DOAs of uncorrelated signals are estimated using conventional subspace method firstly, then the information of the uncorrelated signals can be eliminated by using matrix difference technique, and finally the coherent signals are decorrelated to be estimated. The theoretical analysis and simulation results show that the proposed method is effective.
Chain Dynamics of a Weakly Adsorbing Polymer in Thin Films (2009)

Thin films of weakly adsorbing poly(dimethyl siloxane) (PDMS) on porous alumina are examined with NMR fast field cycling (FFC) relaxometry and NMR transverse relaxometry. The longitudinal relaxation dispersion of polymer amounts corresponding to approximate monolayer coverage shows substantial deviation from the bulk and is characterized by a particularly weak temperature dependence. Thicker films, however, show relaxation behavior and temperature dependence more similar to the bulk polymer. Transverse relaxation times were found to cover a range of several orders of magnitudes for any sample investigated; their dependence on temperature is a function of the total amount of adsorbed polymer. While thick films see an overall increase of molecular mobility at higher temperatures, monolayer films are best characterized by the decreasing fraction of a short, i.e. relatively rigid, component. These effects are consistent with the concept of two regions, one in which chain dynamics deviate from bulk and another where chain dynamics are reduced but bulk-like, although chains inside each region may also experience motional heterogeneity.
Occupancy-driven facility management and building performance analysis (2017)

Accurate and automated real-time building monitoring is a challenging task due to the large number of different parameters that are involved. This paper presents several aspects of a building monitoring and control system that has been developed. The system is based on a multi-sensorial network which is able to capture sustainability-related metrics due to the use of heterogeneous sensors such as occupancy detection sensors, environmental sensors, power consumption sensors and actuators. The availability of occupancy information at room or zone level which is achieved via the occupancy sensors, offers the opportunity to extract valuable information about the way the building is utilized. Furthermore, as the occupancy patterns considerably affect the building's indoor environmental condition and the consumed energy, occupancy estimation turns into a useful tool for the facility manager to analyze and then improve the building's energy performance and enhance the indoor environmental quality by applying control actions through the actuators. The building information is visualized in the spatio-temporal domain to both the facility manager and the occupants via two different components. The system has been evaluated in real-life conditions at a building which is comprised of different types of spaces. Results showed that useful conclusions are drawn when occupancy information is combined with the other monitored parameters.
Total arterial inertance as the fourth element of the windkessel model (1999)

In earlier studies we found that the three-element windkessel, although an almost perfect load for isolated heart studies, does not lead to accurate estimates of total arterial compliance. To overcome this problem, we introduce an inertial term in parallel with the characteristic impedance. In seven dogs we found that ascending aortic pressure could be predicted better from aortic flow by using the four-element windkessel than by using the three-element windkessel: the root-mean-square errors and the Akaike information criterion and Schwarz criterion were smaller for the four-element windkessel. The three-element windkessel overestimated total arterial compliance compared with the values derived from the area and the pulse pressure method ( P = 0.0047, paired t-test), whereas the four-element windkessel compliance estimates were not different ( P = 0.81). The characteristic impedance was underestimated using the three-element windkessel, whereas the four-element windkessel estimation differed marginally from the averaged impedance modulus at high frequencies ( P = 0.0017 and 0.031, respectively). When applied to the human, the four-element windkessel also was more accurate in these same aspects. Using a distributed model of the systemic arterial tree, we found that the inertial term results from the proper summation of all local inertial terms, and we call it total arterial inertance. We conclude that the fourelement windkessel, with all its elements having a hemodynamic meaning, is superior to the three-element windkessel as a lumped-parameter model of the entire systemic tree or as a model for parameter estimation of vascular properties.
Bayesian variational approximation for the joint detection estimation of brain activity in fMRI (2011)

We address the issue of jointly detect brain activity and estimate brain hemodynamics from functional MRI data. To this end, we adopt the so-called JDE framework introduced in and augmented in with hidden Markov field models to account for spatial dependencies between voxels. This latter spatial addition is essential but also responsible for high computation costs. To face the intractability induced by Markov models, inference in is based on intensive simulation methods (MCMC). In this work we propose an alternative to face this limitation by recasting the JDE framework into a missing data framework and to derive an EM algorithm for inference. We address the intractability issue by considering variational approximations. We show that the derived Variational EM algorithm outperforms the MCMC procedure on realistic artificial fMRI data.
Progressive and interactive analysis of event data using event miner (2003)

Exploring large data sets typically involves activities that iterate between data selection and data analysis, in which insights obtained from analysis result in new data selection. Further, data analysis needs to use a combination of analysis techniques: data summarization, mining algorithms and visualization. This interweaving of functions arises both from the semantics of what the analyst hopes to achieve and from scalability requirements for dealing with large data volumes. We refer to such a process as a progressive analysis. Herein is described a tool, Event Miner, that integrates data selection, mining and visualization for progressive analysis of temporal, categorical data. We discuss a data model and architecture. We illustrate how our tool can be used for complex mining tasks such as finding patterns not occurring on Monday. Further, we discuss the novel visualization employed, such as visualizing categorical data and the results of data mining. Also, we discuss the extension of the existing mining framework needed to mine temporal events with multiple attributes. Throughout, we illustrate the capabilities of Event Miner by applying it to event data from large computer networks.
Effect of metal content on the electrocatalytic activity of AuxPdy mixtures and their use in a glucose membraneless microfluidic fuel cell (2014)

Performance increase of a glucose membraneless microfluidic fuel cell using Au<sub>60</sub>Pd<sub>40</sub> material electrodeposited on the anodic compartment.
Percutaneous-transhepatic creation of a bilioenteric neoanastomosis in a patient with bile duct injury using cone-beam computed tomography (2019)

We describe the creation of a percutaneous transhepatic bilioenteric neoanastomosis with the aid of cone-beam computed tomography (CBCT) in a patient suffering from a complicated bile leak after extensive hepatobiliary surgery. Access to the afferent bowel limb was safely performed in a single-stick manner via transhepatic approach with the aid of real-time navigation fluoroscopic imaging generated by CBCT arteriography. CBCT confirmed access of the afferent limb and absence of peri-anastomotic vessel damage, allowing the successful creation of a bilioenteric neoanastomosis, resolving the patient's biliary leak. The patient is alive and asymptomatic at 12-month follow-up, demonstrating patency of the percutaneous bilioenteric neoanastomosis.
Abstract 6113: Spatially resolved biomarker detection on single cells in TRACERx using multiplex imaging (2022)

Abstract Introduction. Studying cell-to-cell variation within the tumour’s native context is crucial for fully understanding tumour heterogeneity and its impact on disease progression and therapy response. Tumour cells and their surrounding stromal cells can be spatially profiled using multiplex imaging with a growing number of detectable proteins. The methods currently used for identification of cell phenotypes from multiplex imaging data have been initially developed for cells in suspension. Therefore, more accurate and robust approaches are required to account for spatial signal overlap and to automatically detect the presence of biomarkers in spatial proteomics. Methods. We performed imaging mass cytometry on 221 tumour and adjacent normal regions from 81 untreated, non-small cell lung cancer patients in the TRACERx study. Two antibody panels with 35 markers were applied to include a range of phenotypic, functional, and structural biomarkers. Single cells were segmented using deep learning-based approaches, and the measured biomarker intensities per cell were further used to identify cell types and functional states. Results. We developed a computational approach optimised for spatial proteomics for identification of cell types and functional states and automated detection of the presence of biomarkers on single cells. First, we demonstrated that current approaches for cell phenotyping lack reproducibility with subsampling and can produce ambiguous clusters of cells from different cell types. Using a multi-tiered analytical approach in combination with statistical tools, we showed reproducibility between technical and biological replicates. We estimated the performance using orthogonal measurements from flow cytometry and immunohistochemistry from matched tumour samples. This approach has been automated with a scalable and portable Nextflow-based implementation. Conclusions. We developed a streamlined approach that overcame limitations of current methods and quantified single-cell biomarker presence using multiplex imaging with TRACERx. Implemented as open-source, portable and customisable, this pipeline for spatially resolved TME characterisation will allow the study of drug targets expression within their spatial context for a better understanding of therapy efficacy. Citation Format: Mihaela Angelova, Katey Enfield, Alastair Magness, Emma Colliver, Masako Shimato, Claudia Lee, David A. Moore, Febe Van Maldegem, Philip Hobson, Dina Levi, James L. Reading, Crispin T. Hiley, Julian Downward, Erik Sahai, Charles Swanton. Spatially resolved biomarker detection on single cells in TRACERx using multiplex imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6113.
Absorption properties of high-latitude Norwegian coastal water: The impact of CDOM and particulate matter (2016)

We present data from measurements and analyses of the spectral absorption due to colored dissolved organic matter (CDOM), total suspended matter (TSM), phytoplankton, and non-algal particles (NAP) in high-latitude northern Norwegian coastal water based on samples taken in spring, summer, and autumn. The Chlorophyll-a (Chl-a) concentration was found to vary significantly with season, whereas regardless of season CDOM was found to be the dominant absorber for wavelengths shorter than 600 nm. The absorption spectral slope S350−500 for CDOM varied between 0.011 and 0.022 nm−1 with mean value and standard deviation given by (0.015 ± 0.002) nm−1. The absorption spectral slope was found to be strongly dependent on the wavelength interval used for fitting. On average, S280−500 was found to be 43% higher than S350−500. A linear relationship was found between the base 10 logarithm of the absorption coefficient at 440 nm [log(ag(440))] and S350−500. Regardless of season, phytoplankton were the dominant component of the TSM absorption indicating little influence from land drainage. The mean values of the Chl-a specific absorption coefficient of phytoplankton aph*(λ) at 440 nm and 676 nm were 0.052 m2 mg−1 and 0.023 m2 mg−1, respectively, and aph*(λ) was found to vary with season, being higher in summer and autumn than in spring. The absorption spectral slope SNAP, which is the spectral slope of absorption spectrum for non-algal particles, was lower than that for European coastal water in general. It varied between 0.0048 and 0.022 nm−1 with mean value and standard deviation given by (0.0083−1 ± 0.003) nm−1. Comparisons of absorption coefficients measured in situ using an ac-9 instrument with those measured in the laboratory from water samples show a good agreement.
Infrastructure Management under Uncertainty: Latent Performance Approach (1993)

This paper presents a new framework for the analysis of infrastructure performance and the planning of inspection, maintenance, and rehabilitation (M&R) activities. The main facets of this framework are: explicitly modeling the errors in measurement of facility performance indicators; treating the key variable in the process, facility performance, as a latent variable that manifests itself through measured condition indicators; and explicitly analyzing and including in the decision process the uncertainties in infrastructure condition measurement and performance forecasting. Our approach recognizes the errors inherent in the measurement of the condition indicators; these errors are quantified through the use of measurement error models. A model system relating the latent facility performance to explanatory variables and to observed indicators is developed. Our M&R activity planning model accounts for the presence of uncertainty in the output of the inspection of facility condition and the forecasting of facility performance. An application example is presented.
A Web database application model for software maintenance (2003)

Web database application programs may consist of hundreds of files. The interoperations among these files could be complex, and most of them are lack of design documents. When a programmer maintains (changes) some programs of an application, the program files affected by the changes need be updated simultaneously to keep the functional consistency. One major difficulty of maintenance is how to identify these affected parts, especially in Web database applications. In this paper, we present a model, called HED model, for the maintenance of Web database applications. HED model decomposes a Web database application into three diagrams, hyperlink diagrams, entity-relationship diagrams, and data-flow diagrams, which are used to represent different aspects of a Web database application. Based on the HED model, the programs files affected by a program change can be identified precisely via the structure and database analyses. In addition, a maintenance tool is implemented to demonstrate the capability of the HED model.
Excretion of unassembled flagellin by Salmonella typhimurium mutants deficient in hook-associated proteins (1984)

Of the flagellar filamentless mutants of Salmonella typhimurium, the flaV, flaU, and flaW mutants, which are defective in hook-associated proteins, synthesized flagellin molecules, but flagella did not polymerize at the tips of the mutant hooks and were excreted into the culture medium as intact monomers.
Characterization of Cement Alteration Process by Transmission Electron Microscopy with High Spatial Resolution (2006)

Application tests for advanced TEM analysis techniques were carried out to study the cement alteration processes associated with water penetration at high spatial resolution. Prior to TEM analysis, we measured the changes in the penetration coefficient and determined the characteristics of the penetrating water in order to gain a fuller understanding of the overall process. These experiments revealed that the process begins with the preferential dissolution of Ca(OH)2. After most of the Ca(OH)2 is dissolved out, the penetration coefficient increases, while the pH value of the water decreases. It has been demonstrated that scanning transmission electron microscope (STEM) techniques are quite useful for determining local structures and compositions in the cement at sub-micron meter spatial resolution. The preferential dissolution of Ca ions results in refinement of cement grains. When the Ca/Si ratio decreases to 1.05, most grains have a round shape in the sub-micron range. X-ray mapping suggests the formation of 3CaO·A12O3· xSiO2·(6-2x)H2O (x=0-3). Ettringite has been mostly dissolved out. But Mg ions remain still in form of brucite. When Ca/Si reaches 0.91, the morphology has changed to a mixture of fibers and granules. The fibers have been identified as a mixture of Calcium Silicate Hydrate Gel and silica gel. Quantitative EDX composition analyses have demonstrated that the granules are altered products of hydrogrossular, 3CaO·A12O3·2SiO2·2H2O, which have been predicted by previous theoretical studies. It is also been shown that hydrotalcite with Mg and Al has been also formed. The results thus obtained are in principle in accordance with the process predicted by previously proposed thermodynamic models.
Curricular Research for Music and Arts Education (1999)

Topics relevant to curricular research for music and the arts are discussed, limitations of existing curricular research are highlighted, and appropriate research methods common to music and the arts are outlined and described.
Global Regularity of the 3D Axi-symmetric Navier-Stokes Equations with Anisotropic Data (2009)

In this paper, we study the 3D axi-symmetric Navier-Stokes Equations with swirl. We prove the global regularity of the 3D Navier-Stokes equations for a family of large anisotropic initial data. Moreover, we obtain a global bound of the solution in terms of its initial data in some $L^p$ norm. Our results also reveal some interesting dynamic growth behavior of the solution due to the interaction between the angular velocity and the angular vorticity fields.