gebhart/patrepeval huggingface dataset:
Surface orientation of a liquid‐crystalline polymer studied by polarized reflection spectroscopy (1991)

Abstract The polarized reflection spectrum was used to evaluate the surface orientation of extruded sheets of liquid‐crystalline copolyester consisting of 73 mol % 4‐hydroxybenzoic acid units and 27 mol % 2‐hydroxy‐6‐naphthoic acid units. The anisotropy of absorption index was evaluated from the specular reflectance using the Fresnel equation and the Kramers‐Kronig relation. An intense absorption and observed in the ultraviolet region was assigned to the π * ←π transitions of the constituent monomeric units. The observed spectra of the liquidcrystalline polymer were successfully interpreted by use of the spectroscopic data on the monomers. The transition moment directions of the monomeric units were calculated by molecular orbital calculations within the framework of the CNDO/S‐Cl approximation. The Surface orientation functions obtained from polarized reflection spectra were compared with the crystal orientation functions in the bulk, which were obtained from the azimuthal intensity distribution of wide‐angle x‐ray diffraction. The orientation behaviour at the surface of the liquid‐crystalline polymer was shown to be equivalent to the orientation behaviour in the bulk at higher draw‐down ratio.
Avaliação in vitro da atividade leishmanicida de Hymeneae courbaril (2016)

Segundo a Organizacao Mundial da Saude (OMS), atualmente 88 paises se encontram atingidos pela leishmaniose, sendo que cerca de 12 milhoes de pessoas estao infectadas e, aproximadamente 350 milhoes de pessoas estao expostas ao risco de contrair a doenca. As dificuldades quanto a administracao dos medicamentos usados nos dias de hoje e a duracao do tratamento, paralelamente aos efeitos colaterais, tem estimulado pesquisadores a buscar novas substâncias com atividade leishmanicida, principalmente de fontes naturais. Hymenaea courbaril (Familia Fabaceae) tambem conhecida popularmente como jatoba, jitai, aboti-timbai, fava-doce, jatoba-da-caatinga, farinheira, entre outros. Estudos anteriores realizados em nossos laboratorios demonstraram uma atividade leishmanicida in vitro promissora tanto para o extrato hidroalcoolico das cascas como para o extrato hidroalcoolico da polpa de H. courbaril . Ambos os extratos apresentaram CI 50 =0,26 µg/mL. Atraves da CLAE preparativa do extrato hidroalcoolico das cascas foi possivel isolar uma substância codificada como F-1B-3. A analise dos dados de RMN -1 H e RMN- 13 C permitiram a identificacao de F-1B-3 como o diterpeno acido isoozico. Os resultados da atividade leishmanicida in vitro frente a Leishmania amazonensis indicaram uma valor de CI 50 de 42,39 µM (12,80 µg/mL) para a substância F-1B-3. Foi realizada tambem a atividade citotoxica desta substância contra macrofagos peritoniais, resultado em um CC de 31,56 µM (9,53 µg/mL).  Os resultados obtidos ate o presente momento apontam para um possivel efeito sinergico das varias substâncias presentes no extrato.
Space Matching for Highly Efficient Microwave Wireless Power Transmission Systems: Theory, Prototype, and Experiments (2021)

Microwave wireless power transmission (MWPT) via radio waves has been an important research topic of the WPT systems, where the overall power transfer and conversion efficiency is a key factor to evaluate the system performance. The state-of-the-art work on MWPT has only taken the end-to-end power transfer efficiency in free space or the power conversion efficiency of the receiver (rectenna) into consideration separately when optimizing the power transfer efficiency of the overall system. To comprehensively consider the system-level matching of the entire MWPT system, a novel space matching concept, including aperture field matching, power matching, and impedance matching, is proposed for optimizing the overall power transfer efficiency. By using the space matching method in this work, the optimal designs of the subsystem components such as the transmitting antenna, receiving antenna, and rectifying circuit can be separately obtained to avoid the complex systematic optimization of the large-scale and complicated MWPT system, therefore, significantly improving the overall power transfer efficiency by 19.4% compared with the traditional methods, and reducing the complexity in large-scale system-level design. This work will have valuable implications in the system design of MWPT applications.
Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression (2018)

Preclinical studies have demonstrated that anti-galectin-3 (Gal-3) interventions are effective in attenuating cardiac remodeling, fibrosis, and dysfunction. We determined, in a transgenic (TG) mouse model of fibrotic cardiomyopathy, whether Gal-3 expression was elevated and whether Gal-3 played a critical role in disease development. We studied mice with fibrotic cardiomyopathy attributable to cardiac overexpression of human β<sub>2</sub>-adrenoceptors (β<sub>2</sub>-TG). Cardiac expression levels of Gal-3 and fibrotic or inflammatory genes were determined. The effect of Gal-3 inhibition in β<sub>2</sub>-TG mice was studied by treatment with Gal-3 inhibitors ( N-acetyllactosamine and modified citrus pectin) or by deletion of Gal-3 through crossing β<sub>2</sub>-TG and Gal-3 knockout mice. Changes in cardiomyopathy phenotypes were assessed by echocardiography and biochemical assays. In β<sub>2</sub>-TG mice at 3, 6, and 9 mo of age, upregulation of Gal-3 expression was observed at mRNA (~6- to 15-fold) and protein (~4- to 8-fold) levels. Treatment of β<sub>2</sub>-TG mice with N-acetyllactosamine (3 wk) or modified citrus pectin (3 mo) did not reverse cardiac fibrosis, inflammation, and cardiomyopathy. Similarly, Gal-3 gene deletion in β<sub>2</sub>-TG mice aged 3 and 9 mo did not rescue the cardiomyopathy phenotype. In conclusion, the β<sub>2</sub>-TG model of cardiomyopathy showed a robust upregulation of Gal-3 that correlated with disease severity, but Gal-3 inhibitors or Gal-3 gene deletion had no effect in halting myocardial fibrosis, remodeling, and dysfunction. Gal-3 may not be critical for cardiac fibrogenesis and remodeling in this cardiomyopathy model. NEW & NOTEWORTHY We showed a robust upregulation of cardiac galectin-3 (Gal-3) expression in a mouse model of cardiomyopathy attributable to cardiomyocyte-restricted transgenic activation of β<sub>2</sub>-adrenoceptors. However, pharmacological and genetic inhibition of Gal-3 did not confer benefit in this model, implying that Gal-3 may not be a critical disease mediator of cardiac remodeling in this model.
Quantitative Raman spectroscopy for the Ioncell® process: Part 2—quantification of ionic liquid degradation products and improvement of prediction performance through interval PLS (2020)

Abstract One of the main issues associated with ionic liquids (ILs) is their recyclability. Viable recycling concepts can only be developed if one knows what is in the IL mixtures and solutions. In our previous work, we showed that it is possible to quantify water and 1.5-diazabicyclo[4.3.0]non-5-enium acetate [DBNH][OAc] IL components in liquid mixtures using Raman spectroscopy. In this regard, we considered Raman spectroscopy as a promising analytical method for the inline monitoring and control of the Ioncell ® process. In the present work, we push the limits of this analytical method further by extending it to more complex and realistic liquid mixtures including the hydrolysis product 1-(3-aminopropyl)-2-pyrrolidone (APP) that can be formed upon the reaction of 5-diazabicyclo[4.3.0]non-5-ene (DBN) with water. Quantifying APP is important in order to measure the extent of the hydrolysis reaction and apply the right corrective measures to reverse the reaction and to maintain the process within the optimal working conditions. The simultaneous quantification of the four components (Acetic acid, DBN, APP and H 2 O) in typical Ioncell ® liquid streams is investigated using Raman spectroscopy. The sensitivity of the Raman method in quantifying APP is also highlighted in comparison with refractometry, which is widely applied to measure IL concentration in aqueous mixtures. Finally, we propose simple modifications on the multivariate partial least square regression model based on a variable selection algorithm to enhance the accuracy of the predicted calibration values.
Disorder and Diffusion in Mayenite (2010)

Mayenite, Ca12Al14O33, has attracted enormous attention for novel technological applications after the discovery of its high oxygen ionic conductivity. The crystal structure consists of a calcium-aluminate framework, comprising 32 of the 33 oxygen anions. The remaining oxygen is distributed over 1/6 of large cages within the framework. The true structure is heavily disordered and usually non-stoichiometric due to the presence of extra anions and is presented for four samples: pure oxygen mayenite (O-mayenite), partly (O/N-mayenite) and fully (N-mayenite) exchanged by nitrogen and doped with iron (Fe-mayenite). All samples were investigated by neutron powder diffraction up to 1050 C. Data were analysed by the Rietveld method and by difference Fourier methods. As prepared O-mayenite contains O - 2 and OH -, N-and O/N-mayenite also NH - 2 , NH 2-and N 3-, while Fe-mayenite was free of extra radicals. In O-and N-mayenite the extra species are lost under vacuum conditions above ca. 700 C, whereas O/N-mayenite retained NH - 2 up to high temperatures. Diffusion of oxygen proceeds via a jump-like interstitialcy process involving exchange of the "free" oxygen with framework oxygen, coupled to relaxations of Ca ions. In O/N-mayenite NH - 2 diffuses via interstitial process. In Fe-mayenite encaged oxygen is "invisible" due to extreme delocalisation or loss.
Biochemical and Biological Properties of a Recombinant Tissue-Type Plasminogen Activator Derived from the Rat JMI-229 Cell Line (1992)

Recombinant tissue-type plasminogen activator (rt-PA), produced by expression of the genomic t-PA DNA from the JMI-229 cell line, which is of rat origin, in the host cell line, was purified to homogeneity. JMI-229 rt-PA was obtained essentially as a single chain molecule which was quantitatively converted to a two-chain moiety by treatment with plasmin. The plasminogen activating potential of single chain JMI-229 rt-PA was 5-fold lower than that of commercially available human rt-PA (Actilyse) in the absence of fibrin, but comparable in the presence of fibrin; it showed a concentration-dependent binding to fibrin, with a significantly more pronounced binding than Actilyse at low fibrin concentration (85 +/- 8% versus 20 +/- 7% at 0.025 mg/ml fibrin; p = 0.004). In human plasma in the absence of fibrin, the concentrations of both single chain and two-chain JMI-229 rt-PA required to induce 50% fibrinogen degradation in 2 h, were about 15-fold higher than those of Actilyse. Both single chain and two-chain forms of JMI-229 rt-PA and of Actilyse induced a similar time- and concentration-dependent lysis of a 125I-fibrin-labeled plasma clot immersed in human plasma, in the absence of significant systemic fibrinolytic activation. Equally effective concentrations (causing 50% clot lysis in 2 h) were 0.11 or 0.10 micrograms/ml for single chain or two-chain JMI-229 rt-PA, as compared to 0.11 or 0.15 micrograms/ml for single chain or two-chain Actilyse.(ABSTRACT TRUNCATED AT 250 WORDS)
Fuzzy Reliability Design for the Interference Articulation of a Roller Shaft (2001)

With regard to function, the strengths for interference articulation of a roller shaft formed a series system. As the three strength reliabilities conditioned each other, there was a problem for the system reliability to apportion rationally. In fact, there was a transition from safety to deactivation. The state of structure was fuzziness which was in both safety and non-safety states. Therefore the reliability was a fuzzy event which considered the randomness for some design parameters and the fuzziness for the thresholds between generalized strength safety and deactivation. The mathematical model of fuzzy reliability design for the interference articulation of the roller shaft was presented. Eight design examples were calculated. ``
CrossFitmodul : Examensarbete, produktutveckling - konstruktion (2012)

Denna rapport innefattar ett examensarbete av Jimmy Kamarainen Bergstrand, studerande pa Malardalens Hogskola inom Ingenjorsprogrammet, Innovation och produktdesign.Uppdraget har utforts for foreta ...
Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology (2017)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01829750.
Preparation and Characterization of the Polyurethane-Chitinous Composite Packaging Film (2017)

Objective: Preparation of the novel material for biodegradable plastic packing. Methods: Copolymerization of polyurethane and chitinous is used for preparation the composite packaging films. Results: The copolymers of Polyurethane-Chitinous was prepared with Screw extrusion method. Moreover, the oil penetration and In vitro biodegradation were employed to characterize the copolymers. Conclusion: The results revealed that the introduction of chitinous would decrease the oil penetration, meanwhile, the heat sealability of copolymers can be kept within quality standard range, which were important to the use as the food packaging.
Apolipoprotein(a) and plasminogen interactions with fibrin: a study with recombinant apolipoprotein(a) and isolated plasminogen fragments (1992)

Lipoprotein(a) [Lp(a)], but not low-density lipoprotein (LDL), was previously shown to impair the generation of fibrin-bound plasmin [Rouy et al. (1991) Arterioscler. Thromb. 11, 629-638] by a mechanism involving binding of Lp(a) to fibrin. It was therefore suggested that the binding was mediated by apolipoprotein(a) [apo(a)], a glycoprotein absent from LDL which has a high degree of homology with plasminogen, the precursor of the fibrinolytic enzyme plasmin. Here we have evaluated this hypothesis by performing comparative fibrin binding studies using a recombinant form of apo(a) containing 17 copies of the apo(a) domain resembling kringle 4 of plasminogen, native Lp(a), and Glu-plasminogen (Glu1-Asn791). Attempts were also made to identify the kringle domains involved in such interactions using isolated elastase-derived plasminogen fragments. The binding experiments were performed using a well-characterized model of an intact and of a plasmin-digested fibrin surface as described by Fleury and Anglés-Cano [(1991) Biochemistry 30, 7630-7638]. Binding of r-apo(a) to the fibrin surfaces was of high affinity (Kd = 26 +/- 8.4 nM for intact fibrin and 7.7 +/- 4.6 nM for plasmin-degraded fibrin) and obeyed the Langmuir equation for adsorption at interfaces. The binding to both surfaces was inhibited by the lysine analogue AMCHA and was completely abolished upon treatment of the degraded surface with carboxypeptidase B, indicating that r-apo(a) binds to both the intrachain lysines of intact fibrin and the carboxy-terminal lysines of degraded fibrin. As expected from these results, both r-apo(a) and native Lp(a) inhibited the binding of Glu-plasminogen to the fibrin surfaces.(ABSTRACT TRUNCATED AT 250 WORDS)
Characterization of Antimicrobial-Producing Beneficial Bacteria Isolated from Huanglongbing Escape Citrus Trees (2017)

The microbiome associated with crop plants has a strong impact on their health and productivity. <i>Candidatus</i> Liberibacter asiaticus (Las), the bacterial pathogen responsible for Huanglongbing (HLB) disease, lives inside the phloem of citrus plants including the root system. It has been suggested that Las negatively affects citrus microbiome. On the other hand, members of citrus microbiome also influence the interaction between Las and citrus. Here, we report the isolation and characterization of multiple putative beneficial bacteria from healthy citrus rhizosphere. Firstly, six bacterial strains showing antibacterial activity against two bacteria closely related to Las: <i>Agrobacterium tumefaciens</i> and <i>Sinorhizobium meliloti</i> were selected. Among them, <i>Burkholderia metallica</i> strain A53 and <i>Burkholderia territorii</i> strain A63 are within the β-proteobacteria class, whereas <i>Pseudomonas granadensis</i> strain 100 and <i>Pseudomonas geniculata</i> strain 95 are within the γ-proteobacteria class. Additionally, two gram-positive bacteria <i>Rhodococcus jialingiae</i> strain 108 and <i>Bacillus pumilus</i> strain 104 were also identified. Secondly, antimicrobial activity against three fungal pathogens: <i>Alternaria alternata</i>, <i>Colletotrichum acutatum</i>, <i>Phyllosticta citricarpa</i>, and two oomycetes: <i>Phytophthora nicotianae</i> and <i>Phytophthora palmivora.</i> Four bacterial strains <i>Burkholderia territorii</i> A63, <i>Burkholderia metallica</i> A53, <i>Pseudomonas geniculata</i> 95, and <i>Bacillus pumilus</i> 104 were shown to have antagonistic activity against the citrus root pathogen <i>Phytophthora nicotianae</i> based on dual culture antagonist assays and compartmentalized petri dish assays. The four selected bacteria were sequenced. Genes involved in phosphate solubilization, siderophore production and iron acquisition, volatile organic compound production, osmoprotection and osmotic tolerance, phytohormone production, antagonism, and nutrient competition were predicted and discussed related to the beneficial traits.
Estradiol and tamoxifen interactions with thyroid hormone in the ovariectomized-thyroidectomized rat (1995)

Receptors for estrogens and thyroid hormone (T3) have related DNA-binding domains that interact with closely related DNA target sequences which enable transcriptional control. In vitro molecular studies have raised the possibility that estrogen and T3 receptors may compete for binding to certain DNA target sites (cross-talk). However, there have been no physiological studies evaluating the abilities of estrogens or T3 to mimic or inhibit each other in vivo in a manner consistent with a mechanism involving receptor cross-talk. To address this issue, the effects of estradiol, tamoxifen (an antiestrogen), and T3 were studied in an ovariectomized-thyroidectomized rat model designed to minimize hormone interplay occurring via neuroendocrine or pharmacokinetic mechanisms. The T3 responses examined included induction of GH, somatic growth, and hepatic malic enzyme, and suppression of TSH secretion. The estrogen responses examined included induction of pituitary kallikrein, PRL, and uterine weight; increases in serum triglycerides; and suppression of LH secretion. Estradiol and tamoxifen acted as partial T3 agonists on GH induction, with agonist or antagonist effects depending upon T3's presence. Estradiol and tamoxifen acted as pure T3 antagonists on T3 induction of somatic growth and malic enzyme. Similarly, estradiol blocked T3-evoked decreases in bone mineral density and had no effect on bone in T3's absence. In contrast, estradiol or tamoxifen did not alter T3 feedback inhibition of TSH release or T3 induction of PRL. T3 partially mimicked estrogen actions to suppress LH, but did not mimic or inhibit other estrogen responses. Interestingly, the effect of estradiol and tamoxifen to increase serum triglycerides was totally T3 dependent even though T3 tended to decrease triglyceride levels. The results indicate that physiological effects of estrogens on GH, somatic growth, bone, malic enzyme, and serum triglycerides exhibit properties suggestive of a mechanism involving cross-talk with T3 receptors. Tamoxifen fully mimicked the effects of estradiol arising by an apparent antagonism of T3 actions, but acted as an antiestrogen in other responses.
[Screen in vivo induced gene of Mycobacterium tuberculosis by IVIAT]. (2005)

In order to search new candidates of pharmaceutical target, in vivo induced antigen technology (IVIAT) was used to screen in vivo induced (ivi) genes of Mycobacterium tuberculosis (M. TB). Genomic expression library of M. TB was first constructed with an inducible plasmid pKK223-8; the titer of the library was 1.02 x 10(5) CFU. Sera from ten tuberculosis patients were pooled and absorbed against in vitro-grown M. TB and Escherichia coli, and used to probe the genomic expression library. 16 positive clones were identified by immunological screen, including 22 ORF: two encoding lipid metabolism proteins, five information pathways proteins, two PE/PPE proteins, six intermediary metabolism and respiration proteins, one cell wall and cell processes protein, four conserved hypothetical proteins and two conserved hypothetical proteins with an orthologue in Mycobacterium bovis. Parts of these genes can be used as candidates of pharmaceutical target because they may be relate with virulence.
Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer (2022)

This is the first study in human cancer with high-throughput gene expression analysis in nerves with striking correlations between transcriptomic profile and clinical outcomes. Our work illuminates nerve-cancer interactions suggesting that cancer-induced injury modulates neuritogenesis, and supports reclassification of PNI based on nerve-tumor distance rather than current subjective criteria.
ChemInform Abstract: The Structure of a PWO:La3+ Crystal (PWO: PbWO4). (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytic Formation of Asymmetric Carbodiimides at Mononuclear Chromium(II/IV) Bis(alkoxide) Complexes (2015)

Herein we report the synthesis of Cr imido complexes in bis(alkoxide) ligand environments and their nitrene transfer reactivity with isocyanides. The reaction of Cr2(OR)4 (OR = OCtBu2Ph) with bulky aryl or alkyl azide results in the formation of the trigonal-planar Cr(IV) mono(imido) complexes Cr(OR)2(NR1), whereas less bulky aryl azides form the Cr(VI) bis(imido) complexes Cr(OR)2(NR1)2. Cr(IV) mono(imido) complexes undergo facile reaction with 1 equiv of 2,6-dimethylphenyl isocyanide (CNR2) to form the corresponding carbodiimides R1NCNR2. In contrast, no reaction of Cr(OR)2(NR1)2 complexes with CNR2 is observed. The reaction of Cr(OR)2(NR1) with excess isocyanide leads to the isolation of the Cr(II) complex Cr(OR)2(CNR2)4, along with the observation of the anticipated carbodimide product. Cr(OR)2(CNR2)4, which can also be obtained by treating Cr2(OR)4 with 4 equiv of isocyanide, reacts with azides N3R1 (R1 = adamantyl, mesityl) to produce the respective carbodiimides. Catalytic formation of carbodiimides R1NCNR2 is observed from the mixtures of azides R1N3 (R1 = mesityl, 2,6-diethylphenyl, 2-isopropylphenyl, adamantyl) and several different aryl isocyanides CNR2 using 2.5 mol % of Cr2(OR)4.
SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability (2020)

Abstract Atypical teratoid rhabdoid tumors (ATRT) are challenging pediatric brain cancers which are predominantly associated with inactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF complex, which has known contributions to developmental processes. To identify potential interactions between SMARCB1 loss and the process of neural development, we introduced an inducible SMARCB1 loss of function system into human induced pluripotent stem cells (iPSCs) which were subjected to either directed neuronal differentiation or differentiation into cerebral organoids. Using this system, we have identified substantial differences in the downstream effects of SMARCB1 loss depending on differentiation state and identified an interaction between SMARCB1 loss and neural differentiation pressure which causes a resistance to terminal differentiation and a defect in maintenance of a normal cell state. Our results provide insight into how SMARCB1 loss might interact with neural development in the process of ATRT tumorigenesis.