gebhart/patrepeval huggingface dataset:
APLICAÇÃO DE REDES NEURAIS CONVOLUCIONAIS NO RECONHECIMENTO DE CARACTERES EM PLACAS INFORMATIVAS JAPONESAS (2021)

Unlike most Western countries, which have a Latin-derived base alphabet, Japan has two syllabic alphabets called Hiragana and Katakana, and a Chinese alphabet, called Kanji. The vast differences in the writing of these Eastern alphabets to Western alphabets, Western alphabet-based OCR algorithms tend not to efficiently detect Japanese characters. This work contributes to a methodology applying digital image processing techniques, such as color range-based segmentation, edge detection and mathematical morphology techniques, to detect Japanese traffic informationalplates correctly the perspective and segment the characters contained in it. A convolutional neural network wasused to perform the classification of Hiragana characters contained in the segmented plates, withaccuracyof 94.37%.
Control of amyloid assembly by autoregulation (2012)

The assembly of proteins into amyloid fibrils can be an element of both protein aggregation diseases and a functional unit in healthy biological pathways. In both cases, it must be kept under tight control to prevent undesired aggregation. In normophysiology, proteins can self-chaperone amyloidogenic segments by restricting their conformational flexibility in an overall stabilizing protein fold. However, some aggregation-prone segments cannot be controlled in this manner and require additional regulatory elements to limit fibrillation. The present review summarizes different molecular mechanisms that proteins use to control their own assembly into fibrils, such as the inclusion of a chaperoning domain or a blocking segment in the proform, the controlled release of an amyloidogenic region from the folded protein, or the adjustment of fibrillation propensity according to pH. Autoregulatory elements can control disease-related as well as functional fibrillar protein assemblies and distinguish a group of self-regulating amyloids across a wide range of biological functions and organisms.
Infrared mapping of M82 - A starburst in an edge-on barred galaxy (1991)

We present new 1-30 micron images of the starburst galaxy M82. The appearance of M82 at 2 micron indicates that a bar ~ 1 kpc long is located at its center. This bar may dramatically influence the gas dynamics and may have caused the formation of the central gas and dust toroid associated with the luminous episode of star formation. Our mid-IR maps define the structure of the toroid out to 30 micron and show that the extent of the emitting region is at least 1.3 kpc. The absorption optical depth determined from 1-2 micron colors corresponds to A_V_ &lt;~ 8 and is distributed in a ridge spanning the starburst region and closely resembling the distribution of H I optical depth. Finally, we consider the contribution that very small grains may make to the 10 micron emission and conclude by comparison to Galactic H II regions that their mid-IR emission is significant.
Incidence and survival outcomes in patients with upper urinary tract urothelial carcinoma diagnosed with variant histology and treated with nephroureterectomy (2019)

We found that one out of 10 patients with UTUC treated with RNU had variant histology. Only micropapillary and sarcomatoid variants were associated with poorer oncological outcomes after adjusting for available confounding factors.
Optical scattering measurements of random anti-reflective nanostructured surfaces in the mid- and long-wave IR (2020)

Anti-reflective nanostructured surfaces (ARSS) enhance optical transmission through suppression of Fresnel reflection at boundaries between layered media. Previous studies show random ARSS (rARSS) exhibit broadband enhancement in transmission and polarization insensitivity compared to typical optical windows. ZnSe samples with rARSS treatment were characterized (transmittance, reflectance, and angular scatter) in the mid-wave and long-wave infrared (2 - 12 μm) using a spectrophotometer. Five different random nano-roughness antireflective surfaces were tested at: normal incidence transmission and 15° angle of incidence -15 to 45° angle of reflection. The angular reflectance distribution resembles a diffuse dipole radiator, due to a finite elongated beam cross-section at the incident surface. Scattering diagrams with main and side lobes are presented. Comparing specular transmission and reflection with the scattered performance, an accurate determination of the redistribution of incident energy is obtained. Measurements of rms surface roughness using a confocal microscope is presented alongside the scattering data, for assessment of structured surface feature size effects. The results show differences in the scattered intensity, over the wavelength bands of interest, depending on the random topology of the surface. The partial-integrated scatter values were obtained, allowing the comparison of random anti-reflective surfaces to optically flat surfaces.
Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo (1995)

Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE could mediate in vivo functions parallel or antagonistic to those proposed for the putative NOTCH ligand DELTA. Our results demonstrate that Serrate can replace Delta gene function during embryonic neuroblast segregation and that expression of Serrate leads to a NOTCH-dependent suppression of achaete expression in proneural clusters. Our findings strongly suggest that SERRATE functions as an alternative ligand capable of NOTCH activation.
In-vacuum exposure shutter (2023)

An in-vacuum radiation exposure shutter device can be employed to regulate a large footprint light beam. The shutter device includes (a) a source of radiation that generates an energy beam; (2) a shutter that includes (i) a frame defining an aperture toward which the energy beam is directed and (ii) a plurality of blades that are secured to the frame; and (3) device that rotates the shutter to cause the plurality of blades to intercept or allow the energy beam to travel through the aperture. Each blade can have a substantially planar surface and the plurality of blades are secured to the frame such that the planar surfaces of the plurality of blades are substantially parallel to each other. The shutter device is particularly suited for operation in a vacuum environment and can achieve shuttering speeds from about 0.1 second to 0.001 second or faster.
Effect of Large Particles and Fine Precipitates on Recrystallization and Transformation Behaviour of Ti Treated Low Carbon TiO Steel. (1996)

Austenite recrystallization and ferrite transformation behaviour of a Ti treated low carbon TiO steel was studied by uniaxial hot compression in a temperature range of 780 to 1300°C. The results have been compared to that of a conventional TiN steel. It was found that large oxide particles present in TiO teel have shown ability to stimulate recrystallization nucleation and transformation during deformation but failed to accelerate recrystallization of bulk material because of an insufficient volume fraction of these large particles in the steel. The influence of Ti: N ratio in TiO steel is critical to TiN precipitation behaviour which affects microstructural development during thermomechanical processing. TiN precipitates in TiO steel are coarser in comparison to conventional Ti microalloyed steel thus reducing grain boundary pinning effects. It was also found that recrystallization of ferrite in cold worked TiO and TiN steels was not affected significantly by large particles and fine precipitates but controlled by pearlite size and distribution.
Room-temperature magnetoelectric effect in lead-free multiferroic $(1-x)$ Ba$_{0.95}$Ca$_{0.05}$Ti$_{0.89}$Sn$_{0.11}$O$_3$-$(x)$CoFe$_2$O$_4$ particulate composites (2023)

Multiferroic particulate composites $(1-x)$ Ba$_{0.95}$Ca$_{0.05}$Ti$_{0.89}$Sn$_{0.11}$O$_3$-$(x)$CoFe$_2$O$_4$ with ($x$ = 0.1, 0.2, 0.3, 0.4 and 0.5) have been prepared by mechanical mixing of the calcined and milled individual ferroic phases. X-ray diffraction and Raman spectroscopy analysis confirmed the formation of both perovskite Ba$_{0.95}$Ca$_{0.05}$Ti$_{0.89}$Sn$_{0.11}$O$_3$ (BCTSn) and spinel CoFe$_2$O$_4$ (CFO) phases without the presence of additional phases. The morphological properties of the composites were provided by using Field Emission Scanning Electron Microscopy. The BCTSn-CFO composites exhibit multiferroic behavior at room temperature, as evidenced by ferroelectric and ferromagnetic hysteresis loops. The magnetoelectric (ME) coupling was measured under a magnetic field up to 10 kOe and the maximum ME response found to be 0.1 mV /cm/ Oe for the composition 0.7 BCTSn-0.3 CFO exhibiting a high degree of pseudo-cubicity and large density.
Plasmonic nanoparticle-semiconductor composites for efficient solar water splitting (2016)

Review of plasmonic nanoparticle effects on the semiconductors' light absorption, charge transfer and energetics for efficient solar water splitting.
Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients (2017)

End-stage renal disease patients with DM had favorable outcomes with living donor kidney transplantation.
Effect of Temperature on Collagen Extractability and Kramer Shear Force of Restructured Beef (1988)

ABSTRACT Collagen extractability and Kramer shear force were measured for raw and heated restructured beef products made with trimmed (epimysium removed) and untrimmed clods (triceps brachii, infraspinatus, and supraspinatus). Collagen extractability was significantly (p &lt; 0.001) higher for untrimmed samples heated at 50°C than for trimmed samples. Kramer shear forces were significantly higher (p &lt; 0.01) for untrimmed than trimmed when raw or heated at 35°C, 45°C, WC, and 55°C. Collagen extractabilities showed no distinct changes with temperature for trimmed samples. Collagen extractability of untrimmed samples increased then decreased as heating temperature increased. Kramer shear forces decreased between 55°C and 60°C for both trimmed and untrimmed samples.
Potential for including Microdochium dimerum, a biocontrol agent against Botrytis cinerea, into an integrated protection scheme of greenhouse tomatoes (2003)

International audience
Validation of Islet Transport from a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England (2011)

Islet transplantation has become established as a successful treatment for type 1 diabetes complicated by recurrent severe hypoglycemia. In the UK access has been limited to a few centrally located units. Our goal was to validate a quality-assured system for safe/effective transport of human islets in the UK and to successfully undertake the first transplants with transported islets. Pancreases were retrieved from deceased donors in the north of England and transported to King's College London using two-layer method (TLM) or University of Wisconsin solution alone. Islets were isolated and transported back to Newcastle in standard blood transfusion or gas-permeable bags with detailed evaluation pre- and posttransport. In the preclinical phase, islets were isolated from 10 pancreases with mean yield of 258,000 islet equivalents. No significant differences were seen between TLM and University of Wisconsin solution organ preservation. A significant loss of integrity was demonstrated in islets shipped in gas-permeable bags, whereas sterility, number, purity, and viability were maintained in blood transfusion bags. Maintenance of secretory granules and glucose-stimulated insulin secretion was confirmed following transport. A Standard Operating Procedure enabling final pretransplant quality control from a simple side-arm sample was validated. Moreover, levels of insulin and cytokines in transport medium were low, enabling transplant without centrifugation/resuspension at the recipient site. Six clinical transplants of transported islets were undertaken in five recipients with 100% primary graft function and resolution of severe hypoglycemia. Safe and clinically effective islet transport has been established facilitating sustainable NHS funding of a clinical islet transplant program for the UK.
Computational genetics and genomics : tools for understanding disease (2004)

Part I. Theory and Technical Concept Computational Biology: Are We There Yet? Gary Peltz Statistical Theory in QTL Mapping Benjamin Yakir, Anne Pisante, and Ariel Darvasi Haplotype-Based Computational Genetic Analysis in Mice Jianmei Wang and Gary Peltz Haplotype Structure of the Mouse Genome Jianmei Wang, Guochun Liao, Janet Cheng, Anh Nguyen, Jingshu Guo, Christopher Chou, Steven Hu, Sharon Jiang, John Allard, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usuka SNP Discovery and Genotyping: Methods and Applications Jun Wang, Dee Aud, Soren Germer, and Russell Higuchi Part II. Selected Examples: Murine Models of Human Disease Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Models Michael J. Holtzman, Edy Y. Kim, and Jeffrey D. Morton Murine Models of Osteoporosis Robert F. Klein Murine Models of Substance and Alcohol Dependence: Unraveling Genetic Complexities Kim Cronise and John C. Crabbe Murine Models of Alcoholism: From QTL to Gene Chris Downing, Beth Bennett, and Thomas E. Johnson Part III. Selected Examples: The Genetic Basis for Human Disease HLA Polymorphism and Disease Susceptibility Henry A. Erlich Asthma Genetics: A Case Study William Cookson Index
Disruption of Broad Epigenetic Domains in PDAC Cells by HAT Inhibitors (2019)

The spreading of epigenetic domains has emerged as a distinguishing epigenomic phenotype for diverse cell types. In particular, clusters of H3K27ac- and H3K4me3-marked elements, referred to as super-enhancers, and broad H3K4me3 domains, respectively, have been linked to cell identity and disease states. Here, we characterized the broad domains from different pancreatic ductal adenocarcinoma (PDAC) cell lines that represent distinct histological grades. Our integrative genomic analysis found that human derived cell line models for distinct PDAC grades exhibit characteristic broad epigenetic features associated with gene expression patterns that are predictive of patient prognosis and provide insight into pancreatic cancer cell identity. In particular, we find that genes marked by overlapping Low-Grade broad domains correspond to an epithelial phenotype and hold potential as markers for patient stratification. We further utilize ChIP-seq to compare the effects of histone acetyltransferase (HAT) inhibitors to detect global changes in histone acetylation and methylation levels. We found that HAT inhibitors impact certain broad domains of pancreatic cancer cells. Overall, our results reveal potential roles for broad domains in cells from distinct PDAC grades and demonstrate the plasticity of particular broad epigenomic domains to epigenetic inhibitors.
Method for the Determination of Catechin and Epicatechin Enantiomers in Cocoa-Based Ingredients and Products by High-Performance Liquid Chromatography: Single-Laboratory Validation (2012)

A single-laboratory validation study was performed for an HPLC method to identify and quantify the flavanol enantiomers (+)- and (-)-epicatechin and (+)- and (-)-catechin in cocoa-based ingredients and products. These compounds were eluted isocratically with an ammonium acetate-methanol mobile phase applied to a modified beta-cyclodextrin chiral stationary phase and detected using fluorescence. Spike recovery experiments using appropriate matrix blanks, along with cocoa extract, cocoa powder, and dark chocolate, were used to evaluate accuracy, repeatability, specificity, LOD, LOQ, and linearity of the method as performed by a single analyst on multiple days. In all samples analyzed, (-)-epicatechin was the predominant flavanol and represented 68-91% of the total monomeric flavanols detected. For the cocoa-based products, within-day (intraday) precision for (-)-epicatechin was between 1.46-3.22%, for (+)-catechin between 3.66-6.90%, and for (-)-catechin between 1.69-6.89%; (+)-epicatechin was not detected in these samples. Recoveries for the three sample types investigated ranged from 82.2 to 102.1% at the 50% spiking level, 83.7 to 102.0% at the 100% spiking level, and 80.4 to 101.1% at the 200% spiking level. Based on performance results, this method may be suitable for routine laboratory use in analysis of cocoa-based ingredients and products.
PEP444c encoded within the MIR444c gene regulates microRNA444c accumulation in barley (2023)

ABSTRACT MicroRNAs are small, non-coding RNA molecules that regulate expression of their target genes. The MIR444 gene family is present exclusively in monocotyledons, and microRNAs444 from this family have been shown to target certain MADS-box transcription factors in rice and barley. We identified three barley MIR444 ( MIR444a / b / c ) genes and comprehensively characterized their structure and the processing pattern of the primary transcripts (pri-miRNAs444). Pri-microRNAs444 undergo extensive alternative splicing, by which functional and non-functional pri-miRNA444 isoforms are generated. We show that barley pri-miRNAs444 contain numerous open reading frames (ORFs) whose transcripts associate with ribosomes. Using specific antibodies, we provide evidence that selected ORFs encoding PEP444a within MIR444a and PEP444c within MIR444c are expressed in barley plants. Moreover, we demonstrate that CRISPR-associated endonuclease 9 (Cas9)-mediated mutagenesis of the PEP444c encoding sequence results in a decreased level of PEP444 transcript in barley shoots and roots, and a 5-fold reduced level of mature microRNA444c in roots. Taken together, our observations suggest that PEP444c encoded by the MIR444c gene is involved in microRNA444c biogenesis in barley.
Meeting Report: The Fourth Genomic Standards Consortium (GSC) Workshop (2008)

This meeting report summarizes the proceedings of the fifth Genomic Standards Consortium (GSC) workshop held December 12-14, 2007, at the European Bioinformatics Institute (EBI), Cambridge, UK. This fifth workshop served as a milestone event in the evolution of the GSC (launched in September 2005); the key outcome of the workshop was the finalization of a stable version of the MIGS specification (v2.0) for publication. This accomplishment enables, and also in some cases necessitates, downstream activities, which are described in the multiauthor, consensus-driven articles in this special issue of OMICS produced as a direct result of the workshop. This report briefly summarizes the workshop and overviews the special issue. In particular, it aims to explain how the various GSC-led projects are working together to help this community achieve its stated mission of further standardizing the descriptions of genomes and metagenomes and implementing improved mechanisms of data exchange and integration to enable more accurate comparative analyses. Further information about the GSC and its range of activities can be found at http://gensc.org.
Immediate effect of orthopedic shoe and functional foot orthosis on center of pressure displacement and gait parameters in juvenile flexible flat foot (2013)

An orthopaedic shoe can be expensive, and in particular heavy with most children reluctant to wear it. This study focussed on the CoP displacement and selected gait parameters with an orthopaedic shoe and functional foot orthosis, and showed that a combined prescription of a functional foot orthosis and with regular shoes may be a useful alternative for children with moderate flat foot.
Influence de la stéréorégularité de poly(3-alkylthiophènes) photodopes sur la stabilité thermique de la conductivité électrique (1995)

La stéréorégularité des polymères joue un rôle clef pour la conductivité électrique des poly(3-alkylthiophènes). Différentes méthodes de synthèse ont été réalisées menant à des polymères de stéréorégularités différentes dont le comportement de la conductivité électrique a été étudié. Le photodopage des polymères a été obtenu par photodissociation de matériaux de type sels d'oniums. L'influence de différentes atmosphères et l'effet de la température sur la cinétique de dégradation ont été étudiés. Le photodopage de tels systèmes a été appliqué à la réalisation de réseaux résistifs de haute résolution par des techniques de lithographie.
The evolution of an x86 virtual machine monitor (2010)

Twelve years have passed since VMware engineers first virtualized the x86 architecture. This technological breakthrough kicked off a transformation of an entire industry, and virtualization is now (once again) a thriving business with a wide range of solutions being deployed, developed and proposed. But at the base of it all, the fundamental quest is still the same: running virtual machines as well as we possibly can on top of a virtual machine monitor. We review how the x86 architecture was originally virtualized in the days of the Pentium II (1998), and follow the evolution of the virtual machine monitor forward through the introduction of virtual SMP, 64 bit (x64), and hardware support for virtualization to finish with a contemporary challenge, nested virtualization.
Clinical Practice Guideline for Stroke Rehabilitation in Korea—Part 1: Rehabilitation for Motor Function (2022) (2023)

This clinical practice guideline (CPG) is the fourth edition of the Korean guideline for stroke rehabilitation, which was last updated in 2016. The development approach has been changed from a consensus-based approach to an evidence-based approach using the Grading of Recommendations Assessment Development and Evaluation (GRADE) method. This change ensures that the guidelines are based on the latest and strongest evidence available. The aim is to provide the most accurate and effective guidance to stroke rehabilitation teams, and to improve the outcomes for stroke patients in Korea. Fifty-five specialists in stroke rehabilitation and one CPG development methodology expert participated in this development. The scope of the previous clinical guidelines was very extensive, making it difficult to revise at once. Therefore, it was decided that the scope of this revised CPG would be limited to Part 1: Rehabilitation for Motor Function. The key questions were selected by considering the preferences of the target population and referring to foreign guidelines for stroke rehabilitation, and the recommendations were completed through systematic literature review and the GRADE method. The draft recommendations, which were agreed upon through an official consensus process, were refined after evaluation by a public hearing and external expert evaluation.
Unlicensed millimeter wave communications. A new opportunity for MMIC technology at 60 GHz (2002)

A recent FCC decision has opened the largest contiguous bandwidth in history, 59-64 GHz for non-government unlicensed wireless communications. Emerging commercial applications in this band will require inexpensive MMICs and low-cost packaging. Will technology be up to the challenge?.
Current-Phase Relation in Josephson Junctions with Complex Ferromagnetic/Normal Metal Interlayers (2012)

In the frame of Usadel equation the two-dimensional nonlinear boundary problem for heterostructures with complex ferromagnetic (F)/normal metal (N) interlayer has been solved numerically for arbitrary values of electrodes spacing L , thickness d N and d F of N and F films. We calculate the current-phase relations for ramp-type S-NF-S and overlap-type SFN-FN-NFS junctions. We have found the range of parameters providing an opportunity for realization of Josephson φ -junction based on the considered structures.