gebhart/patrepeval huggingface dataset:
CooC and CooD are required for assembly of CS1 pili (1994)

Many strains of enterotoxigenic Escherichia coli (ETEC) isolated from patients with diarrhoeal disease exhibit CS1 pili on their surfaces. These appendages, which are thought to be important for colonization of the upper intestine, are composed largely of multiple identical protein subunits encoded by cooA. We have sequenced the DNA directly downstream of cooA and identified two open reading frames, cooC and cooD, transcribed in the same direction as cooB and cooA. Following cooD is DNA homologous to an insertion sequence, so cooB, A, C and D appear to encode all the information needed for E. coli K-12 to synthesize CS1 pili. Complementation analysis of mutants cloned in E. coli K-12 and constructed in an ETEC-derived strain indicates that cooC and cooD are not required for stability of the major CS1 pilin protein or for its transport to the periplasm, but, like cooB, both are needed for assembly of cooA into pili.
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin (2022)

Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end-directed motor. Dynein motility requires Dynactin and a family of activating adaptors that stabilize the Dynein-Dynactin complex and promote regulated interactions with cargo in space and time. How activating adaptors limit Dynein activation to specialized subcellular locales is unclear. Here, we reveal that Spindly, a mitotic Dynein adaptor at the kinetochore corona, exists natively in a closed conformation that occludes binding of Dynein-Dynactin to its CC1 box and Spindly motif. A structure-based analysis identified various mutations promoting an open conformation of Spindly that binds Dynein-Dynactin. A region of Spindly downstream from the Spindly motif and not required for cargo binding faces the CC1 box and stabilizes the intramolecular closed conformation. This region is also required for robust kinetochore localization of Spindly, suggesting that kinetochores promote Spindly activation to recruit Dynein. Thus, our work illustrates how specific Dynein activation at a defined cellular locale may require multiple factors.
NEW CONCEPTS IN THE DIAGNOSIS AND MANAGEMENT OF NEUROCYSTICERCOSIS (TAENIA SOLIUM) (2005)

Human neurocysticercosis, the infection of the nervous system by the larvae of Taenia solium, is a major cause of epileptic seizures and other neurologic morbidity worldwide. The diagnosis and treatment of neurocysticercosis have been considerably improved in recent years. This improvement includes identification and sequencing of specific antigens and development of new assays for laboratory diagnosis, recognition of the frequency and significance of edema around old, calcified cysts (associated to symptomatic episodes), results of a randomized blinded control treatment trial on treatment efficacy for intraparenchymal disease showing a clinical benefit of decreased seizures, and a much better assessment of the frequency and spectrum of cerebrovascular complications. These advances now permit a much better integration of clinical, serologic, and imaging data for diagnosis and therapeutic purposes.
The opportunity for sexual selection and the evolution of non-responsiveness to pesticides, sterility inducers and contraceptives (2018)

We illustrate a method for delaying and possibly eliminating the evolution of non-responsiveness to the treatments now used to control pest populations. Using simulations and estimates of the variance in relative fitness, i.e., the opportunity for selection, in a rat-like mammal, we show that the selection responsible for the evolution of non-responsiveness to pesticides and sterility-inducers, is similar in its action to sexual selection, and for this reason can be orders of magnitude stronger than that which exists for untreated populations. In contrast, we show that when contraceptives are used to reduce the fertility of a pest species, with non-responders embedded within such populations, the opportunity for selection favoring non-responsiveness is reduced to that which is expected by chance alone. In pest species with separate sexes, we show that efforts to control pest populations or to mitigate selection favoring non-responsiveness, are likely to be ineffective when members of one sex are sterilized or killed. We also show that while mating preferences can impede the rate at which resistance evolves, they are more likely to accelerate this process, arguing against the use of sterile male approaches for controlling pests. Our results suggest that contraceptives are more effective at controlling pest populations and slowing the evolution of non-responsiveness than treatments that cause sterilization or death in target species. Furthermore, our results indicate that contraceptives that work differentially on each sex will be most effective in mitigating selection favoring non-responders. Our results have significant implications for the development and application of treatments to manage pests, now and into the future.
A relative approach to opinion formation (2021)

Formal models of opinion formation commonly represent an individual's opinion by a value on a fixed opinion interval. We propose an alternative modeling method wherein interpretation is only provided to the relative positions of opinions vis-à-vis each other. This method is then considered in a similar setting as the discrete-time Altafini model (an extension of the well-known DeGroot model), but with more general influence weights. Even in a linear framework, the model can describe, in the long run, polarization, dynamics with a periodic pattern, and (modulus) consensus formation. In addition, in our alternative approach key characteristics of the opinion dynamic can be derived from real-valued square matrices of influence weights, which immediately allows one to transfer matrix theory insights to the field of opinion formation dynamics under more relaxed conditions than in the DeGroot or discrete-time Altafini models. A few specific themes are covered: (i) We demonstrate how stable patterns in relative opinion dynamics are identified which are hidden when opinions are considered in an absolute opinion framework. (ii) For the two-agent case, we provide an exhaustive closed-form description of the relative opinion model's dynamic in the long run. (iii) We explore group dynamics analytically, in particular providing a non-trivial condition under which a subgroup's asymptotic behavior carries over to the entire population.
An Extended Normalized Multichannel Flms Algorithm For Blind Channel Identification (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
EVALUATION OF SEQUENTIAL SERUM INTERLEUKIN-6 LEVELS IN LIVER ALLOGRAFT RECIPIENTS (1994)

Control serum levels of IL-6 measured by ELISA in 30 healthy blood donors or volunteers were 18±34 pg/ml (mean ± SD). Pretransplant serum levels of IL-6 in 169 adult candidates for liver transplantation were significantly higher than control in those with fulminant hepatitis (203±232 pg/ml), alcoholic cirrhosis (116±257 pg/ml), and hepatocellular carcinoma (82±105 pg/ml). With these data as background, plasma or serum levels of IL-6 were monitored in 24 adult patients after first OLT and correlated with the clinical courses and the histopathological diagnosis of rejection. Serum or plasma levels of IL-6 decreased after transplantation regardless of pretransplant value. Four patients with infection subsequently developed continuously high IL-6 values. In the 20 of 24 patients who did not have infection, significantly higher levels of IL-6 were consistently found 0–4 days before histopathological diagnosis of rejection (131±78 pg/ml) compared with significantly lower values in patients without rejection episodes (40±21 pg/ml). The elevations of IL-6 were spike shaped, did not correlate well with the histopathological grades of rejection, and were highly responsive to augmented immunosup-pression. These 20 cases were classified as: group 1, no spikes of IL-6 after liver transplantation; group 2, single spike of IL-6 after liver transplantation; and group 3, multiple spikes of IL-6 after liver transplantation. The combined early and late graft loss of each group was 0% (group 1), 25% (group 2), and 67% (group 3). We conclude that daily monitored serum or plasma IL-6 levels can be a good premonitor of liver allograft rejection and also a useful predictor of long-term graft outcome.
Alpha AXP architecture (1993)

article Free Access Share on Alpha AXP architecture Author: Richard L. Sites Digital Equipment Corp., Littleton, MA Digital Equipment Corp., Littleton, MAView Profile Authors Info & Claims Communications of the ACMVolume 36Issue 2Feb. 1993 pp 33–44https://doi.org/10.1145/151220.151226Published:01 February 1993Publication History 60citation990DownloadsMetricsTotal Citations60Total Downloads990Last 12 Months46Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Stabilization of Neutral Systems with Saturating Control Inputs (2010)

International audience
Electroless nickel/copper plating as a new bump metallization (1995)

An electroless bumping method was developed both for flip chip and TAB applications. Electroless Ni/Cu plating is a maskless low-cost approach to bumping directly on aluminum bondpads. An immersion tin layer for coating and soldering is plated on the copper. Due to the high alkalinity (pH>12) of electroless Cu baths, a thick Ni layer of about 7 /spl mu/m is required on the aluminum for seating. A shear strength of 180 cN and a contact resistance of less than 2 m/spl Omega/ for the bumps were obtained. Because of the high hardness of nickel, conventional gang bonding techniques are not applicable. The hardness of electroless copper is about 200 mHV/sub 25/, and after annealing in the range of 130-150 mHV/sub 25/ thermocompression gang bonding of Au plated tape to the Ni/Cu/Sn metallization was carried out. The average pull strength was 50 cN. The influences of the size and electroless solder plating of the deposited copper are also investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The detective quantum efficiency of CCD and vidicon-based detectors for X-ray crystallographic applications (1992)

The detective quantum efficiency (DQE) characterizes the measurement uncertainty introduced by a detector. A formulation of the DQE for CCD and vidicon-based X-ray integrating detectors is developed and illustrated with five model detectors. A comparison of the calculated and measured DQEs for two of these detectors is presented. From an examination of the DQEs for the model detectors, generalizations are made regarding detector designs.
The limits of system improvement through liquid diagonal routing of interconnects (2004)

An interconnect distribution for a system utilizing liquid diagonal routing is rigorously derived. Using the distribution in conjunction with a wiring layer assignment algorithm, the limits of clock frequency and area improvements are quantified as a function of wiring efficiency, the ratio of utilized wiring area to those available. A liquid-routed system with only a 28% wiring efficiency is equivalent to an orthogonally routed system with a 40% wiring efficiency. A wiring efficiency of a liquid-routed system below 28% results in an inferior design in regards to clock frequency and/or required metal resources. If a 40% wiring efficiency is maintained, however, the power-constrained clock frequency can be increased by 38% with a 69% reduction in area, or the power-density-constrained area can be reduced by 75% with a 47% reduction in power. Liquid diagonal routing promises improvements to both area and clock frequency if the wiring efficiency is maintained above roughly 30%.
Efficient electron channel through self-aggregation of cytochrome c3 on an artificial membrane (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient electron channel through self-aggregation of cytochrome c3 on an artificial membraneIwao Tabushi, Takako Nishiya, Tatsuhiko Yagi, and Hiroo InokuchiCite this: J. Am. Chem. Soc. 1981, 103, 23, 6963–6965Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ja00413a034https://doi.org/10.1021/ja00413a034research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of prazosin on renal function in congestive heart failure (1980)

Prazosin improves hemodynamics promptly in patients with congestive heart failure (CHF), but tolerance to repeated doses may develop rapidly. To determine if the kidneys play a role in this attenuation of effect, we studied renal responses in nine CHF patients treated with prazosin (5 mg three times a day for 3 days) preceded and followed by 3 days of placebo. Prazosin decreased mean arterial blood pressure from 87.0 +/- 2.2 (mean +/- SEM) to 84.0 +/- 2.0 mm Hg (p < 0.05) with no change in heart rate (73.1 +/- 3.3 bpm on placebo and 73.6 +/- 3.5 bpm on prazosin). The change in creatinine clearance from 81.6 +/- 8.7 to 96.3 +/- 10.4 ml/min with prazosin was not statistically significant, but the slight increase in urine volume from 2.33 +/- 0.22 to 2.51 +/- 0.23 1/24 hr was (p < 0.01). There were no significant changes in serum sodium, potassium, chloride, CO2, blood urea nitrogen, osmolality or glucose, urinary excretion of sodium or potassium, or sodium balance. The data were analyzed for changes within each period but there were no significant changes from day to day. Plasma renin activity rose from 3.93 +/- 0.69 to 4.96 +/- 0.84 ng/ml/hr during prazosin (p < 0.02). Significant alterations in renal function are not likely when patients with CHF are treated with prazosin, and any attenuation of effect of prazosin after repeated doses is not likely due to mechanisms involving alterations in renal function.
Understanding the TiH<sub>(2-x)</sub>/TiO<sub>y</sub> System at Elevated Temperature: A Literature Review (2021)

Titanium hydride of varying TiH stoichiometry is used in pyrotechnic compositions. In order to yield consistent performance, manufacturing processes must be developed to ensure precise and reproducible material properties, including composition and morphology. Legacy synthesis protocols are not comprehensive nor are the required apparatuses still available. To guide the development of novel production procedures, this report reviews literature on relevant chemical reactions and diffusion events occurring at elevated temperature in the TiH (2-x) /TiO y system. Titanium hydride exposed to air spontaneously forms a passivating oxide layer. Upon heating, significant hydrogen release, which is accompanied by changes to the surface oxide layer, is noted by 375 ? 400C. At higher temperatures (above about 500C) the oxide layer is reported to be essentially nonexistent as a result of oxide-layer dissolution processes and, potentially, oxide-layer reduction due to water formation. Based on the reviewed literature, we hypothesize that, by 500C, the surface layer consists of an oxyhydride phase, which is a solid solution of oxygen in titanium hydride. We believe that hydrogen release from titanium hydride is controlled by the kinetics of molecular hydrogen desorption on the oxyhydride surface. No literature data is available for corresponding activation energies of the dynamic desorption process, and the equilibrium phase diagram of this three-component system remains largely unexplored as well. These gaps in knowledge might be addressed through coordinated computational modeling and experimental efforts.
Source of slow transient effects in GaAs photoconductors (1992)

Photoconductive GaAs devices made from a low-doped epitaxial layer on a semi-insulating substrate show transients in their dark-current DC characteristics that persist for up to approximately 2000 s. The authors studied these transients for a range of devices both experimentally and by numerical simulation. They solve simultaneously the Poisson and continuity equations with a model that allows for deep-level traps in the active layer, on the surface of the device, and in the substrate. Results from the model suggest that transients of such long duration arise from deep traps at the surface of the active layer rather than in its bulk. This is shown qualitatively through a series of two-dimensional simulations. Chemical etching of the devices confirms experimentally that conduction near the surface is very important.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chemotaxis and Differentiation of Human Adipose Tissue CD34+/CD31− Progenitor Cells: Role of Stromal Derived Factor-1 Released by Adipose Tissue Capillary Endothelial Cells (2007)

The native CD34+/CD31- cell population present in the stroma-vascular fraction of human adipose tissue (hAT) displays progenitor cell properties since they exhibit adipocyte- and endothelial cell-like phenotypes under appropriate stimuli. To analyze the signals within hAT regulating their phenotypes, the influence of hAT-derived capillary endothelial cells (CECs) was studied on the chemotaxis and differentiation of the hAT-CD34+/CD31- cells. Conditioned medium from hAT-CECs led to a strong chemotaxis of the hAT-CD34+/CD31- cells that was inhibited with pretreatments with pertussis toxin, CXCR-4 antagonist, or neutralizing antibodies. Furthermore, hAT-CECs produced and secreted the CXCR-4 ligand, that is, the stromal derived factor-1 (SDF-1). Finally, hAT-CECs induced the differentiation of hAT-CD34+/CD31- cells toward an endothelial cell (EC) phenotype. Indeed, hAT-CECs and -CD34+/CD31- cell coculture stimulated in a two-dimensional system the expression of the EC CD31 marker by the hAT-progenitor cells and, in a three-dimensional approach, the formation of capillary-like structures via a SDF-1/CXCR-4 dependent pathway. Thus, the migration and differentiation of hAT progenitor cells are modulated by hAT-CEC-derived factors. SDF-1, which is secreted by hAT-derived CECs, and its receptor CXCR-4, expressed by hAT-derived progenitor cells, may promote chemotaxis and differentiation of hAT-derived progenitor cells and thus contribute to the formation of the vascular network during the development of hAT.
ChemInform Abstract: Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mixing Yarns and Triangles in Cloth Simulation (2020)

Abstract This paper presents a method to combine triangle and yarn models in cloth simulation, and hence leverage their best features. The majority of a garment uses a triangle‐based model, which reduces the overall computational and memory cost. Key areas of the garment use a yarn‐based model, which elicits rich effects such as structural nonlinearity and plasticity. To combine both models in a seamless and robust manner, we solve two major technical challenges. We propose an enriched kinematic representation that augments triangle‐based deformations with yarn‐level details. Naïve enrichment suffers from kinematic redundancy, but we devise an optimal kinematic filter that allows a smooth transition between triangle and yarn models. We also introduce a preconditioner that resolves the poor conditioning produced by the extremely different inertia of triangle and yarn nodes. This preconditioner deals effectively with rank deficiency introduced by the kinematic filter. We demonstrate that mixed yarns and triangles succeed to efficiently capture rich effects in garment fit and drape.
Absolute configuration of chiral fullerenes and covalent derivatives from their calculated circular dichroism spectra (1998)

The theoretical circular dichroism (CD) spectra of optically active C60 and C70 bis-adducts with chiral functionalization patterns and of the enantiomers of inherently chiral D2-C76 and its mono-adducts were calculated by the π-electron SCF-CI-DV MO method. By comparison with the experimental CD spectra, the absolute configurations of these compounds were assigned.
MPI reconstruction using Bessel functions (2019)

This publication proposes for the first time a direct reconstruction technique based on weighted Bessel functions of first kind. As basis for the formulation the well-known Chebyshev reconstruction is used. By utilizing the Fourier transform of Chebyshev polynomials of second kind, which is nothing else than a weighted Bessel function of first kind, a new formulation which allows for reconstruction of the particle distribution in the Fourier domain is derived. This method comes with the benefit of allowing for a direct deconvolution in frequency domain. With numerical simulations we show the equivalence to the Chebyshev reconstruction and demonstrate different strategies to perform the deconvolution. Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009017, DOI: 10.18416/IJMPI.2020.2009017
Materials Development for Multifunctional Structural Composite Batteries (2007)

Abstract not Available.
Automated SEM recipe generation for OPC applications (2012)

This work presents software tools that enable engineers to make relevant SEM measurement decisions in the EDA environment, presented in the optimal context for the engineer, and pass them seamlessly into the SEM environment. We present the tools and interfaces leveraged in this solution and explore the benefits of enabling OPC modeling engineers to make metrology-related decisions within the OPC environment. New opportunities for automation of metrologyrelated OPC tasks are also discussed.
Improving Explainability of Recommendation System by Multi-sided Tensor Factorization (2019)

Recently, explainable recommender systems to improve their persuasiveness have attracted attentions. In this regard, some approaches extract information from posts or comments on items and apply them to simple and effective template. These information (e.g., topics and interests), however, are indirectly reflected to the existing recommendation algorithms or models therefore do not directly improve the recommendation accuracy. Moreover, extra resources in deriving information are required. Thereby, we propose a collaborative filtering approach using a tensor which is modeled considering 5Ws aspects and generate explanations by combining factorization results with templates. Quality and explanation of recommendations were evaluated on quantitative/qualitative analyses.