gebhart/patrepeval huggingface dataset:
An Earthworm-Like Microrobot for Colonoscopy (2006)

Miniature robotics for colonoscopy has become a hot research topic with the development of minimally invasive surgery (MIS). In this paper, a novel microrobot for colonoscopy that operates based on a simulation of the squirming motion of the earthworm is described. The robot uses a unique driving unit called a linear electromagnetic driver. The prototype measures 9.5 mm in diameter and 120 mm in length. It is driven by a linear direct current (DC) motor designed and manufactured by the authors. This paper describes the prototype, locomotion principle, and control system in detail. It then describes two models that were built to study the robot's ability to move in the viscoelastic colon environment. A slepe model of motion was developed and some mathematical evaluations of locomotion conditions were conducted. Experiments to test the creeping ability of the prototype on a slope were performed to verify these expressions. From the viscoelastic model relative to acting force between the robot and the colon, a transcendent equation about locomotive efficiency of the critical squirm step was deduced and solved to instruct the design of the robot. Last, in vitro experiments in the fresh colon of a pig were performed. The results show that this kind of microrobot can propel itself freely and reliably in the soft viscoelastic colon. Finally, future areas of research are noted.
LC-Based Bandpass Continuous-Time Sigma-Delta Modulators With Widely Tunable Notch Frequency (2014)

This paper analyses the use of bandpass continuous-time ΣΔ modulators with widely programmable notch frequency for the efficient digitization of radio-frequency signals in the next generation of software-defined-radio mobile systems. The modulator architectures under study are based on a fourth-order loop filter - implemented with two LC-based resonators - and a finite-impulsive-response feedback loop in order to increase their flexibility and degrees of freedom. Several topologies are studied, considering three different cases for the embedded digital-to-analog converter, namely: return-to-zero, non-return-to-zero and raised-cosine waveform. In all cases, a notch-aware synthesis methodology is presented, which takes into account the dependency of the loop-filter coefficients on the notch frequency and compensates for the dynamic range degradation due to the variation of the notch. The synthesized modulators are compared in terms of their sensitivity to main circuit error mechanisms and the estimated power consumption over a notch-frequency tuning range of 0.1f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> to 0.4f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> . Time-domain behavioral and macromodel electrical simulations validate this approach, demonstrating the feasibility of the presented methodology and architectures for the efficient and robust digitization of radio-frequency signals with a scalable resolution and programmable signal bandwidth.
[Hepatic vein thrombosis. Diagnostic and therapeutic difficulties]. (1997)

Budd Chiari syndrome (liver vein thrombosis) may be a diagnostic and therapeutic problem. On the basis of four different cases we review the major diagnostic and therapeutic principles involved. Imaging techniques are necessary in order to establish the diagnosis. Ultrasound examination with Duplex doppler is usually sufficient, but MR angiography is also useful. Treatment options are thrombolysis, surgery or liver transplantation. What treatment is selected will depend on the clinical situation and the prognosis.
Asymmetric Synthesis of Bicyclic β-Lactones via the Intramolecular, Nucleophile-Catalyzed Aldol Lactonization:  Improved Efficiency and Expanded Scope (2005)

[reaction: see text] The intramolecular, nucleophile-catalyzed, aldol lactonization (NCAL) process merges catalytic, asymmetric carbocycle synthesis with beta-lactone synthesis. The application of modified Mukaiyama reagents to this process led to greatly improved conversion and efficiency (70-82% yield) and shorter reaction times with no diminution of enantioselectivity (91-98% ee). The process was extended to several new aldehyde-acid substrates leading to new bicyclic-beta-lactones. This methodology uniquely provides beta-lactone-fused cyclopentanes and cyclohexanes readied for further transformations.
Multi‐Functional Small Molecules with Temporal Charge‐Switchability Tackle Infection and Inflammation (2022)

Abstract The alarming situation in public healthcare caused by ever‐increasing catastrophe of antimicrobial resistance, recurrent infections, and associated inflammation has accelerated the hunt for novel therapeutics which can address these diverse problems concomitantly. This article introduces a new class of multi‐functional amino acid conjugated small antibacterial molecules (ASAMs) which tackle complicated infections and associated inflammation. These molecules exhibit broad‐spectrum bactericidal activity against multi‐drug‐resistant bacteria. The phenylalanine‐bearing lead molecule (ASAM‐ 10 ) tackles bacterial dormant subpopulations, impenetrable biofilms, and intracellular pathogens simultaneously. Importantly, this molecule addresses the problem of toxicity associated with cationic lipopeptides like colistin through the temporal charge switching (cationic to zwitterionic) owing to the degradation of labile ester linkages. However, this does not affect its desired antibacterial action window. The substantial reduction in the overexpression of pro‐inflammatory cytokines (IL‐6, IL‐8, TNF‐α, and IL‐1β) upon treatment of infected macrophages with ASAM‐ 10 validates its anti‐inflammatory efficacy. Furthermore, bacteria exhibit diminished susceptibility toward resistance development against ASAM‐ 10 owing to its membrane‐active nature. ASAM‐ 10 displays significant reduction in bacterial burden (2 Log CFU/g) when administered intraperitoneally in mice for MRSA thigh infection. Overall, this new class of multi‐functional molecules is safe for anticipated advanced therapeutic applications to combat complex bacterial infections and inflammation.
Topotactic Transformations of Metal–Organic Frameworks to Highly Porous and Stable Inorganic Sorbents for Efficient Radionuclide Sequestration (2014)

Innovative solid-phase sorbent technologies are needed to extract radionuclides from harsh media for environmental remediation and in order to close the nuclear fuel cycle. Highly porous inorganic materials with remarkable sorptive properties have been prepared by topotactic transformations of metal–organic frameworks (MOFs) using both basic and acidic solutions. Treatment of Ti and Zr nanoMOFs with NaOH, Na3PO4, and H3PO4 yields Ti and Zr oxides, oxyphosphates, and phosphates via sacrificial removal of the organic ligands. This controlled ligand extraction process results in porous inorganic materials, which preserve the original MOF morphologies and impart useful surface functionalities, but are devoid of organic linkers. Structural investigation by X-ray absorption spectroscopy reveals preservation of the coordination environment of the scattering metal. Changing the MOF template introduces different metal and structural possibilities, while application of different digest solutions allows preparation of metal oxides, metal oxyphosphates, and metal phosphates. The high stability and porosity of these novel materials makes them ideally suited as nanosorbents in severe environments. Their potential for several radionuclide separations is demonstrated, including decontamination of high level nuclear waste, extraction of lanthanides, and remediation of radionuclide-contaminated seawater.
Object and operation supported maintenance for mining equipment (2014)

The paper aroused in answer to discussion in Mining Magazine (MM) September 2011 and July/August 2013. The paper shows that discussion given in the MM issue July/August 2013 does not fulfill expectations expressed in MM issue 2011. The presented paper is the review on maintenance that is based on condition monitoring as tool for detection of faults and failure prevention. Fault and failure are regarded as inevitable during the machine operation as the process of wear and the process of degradation. The question is, if one can influence the wear and degradation process, using condition monitoring. The paper will present technology (in reference to cited papers) which demonstrates that the use of the proper method can influence the wear and machine degradation process, using proper condition monitoring techniques and knowing scenarios of wear and degradation process, the maintenance can be rationalized. The presented paper shows possible improvements which are needed to fulfill expectations expressed in MM September 2011 and they are not taken into consideration in MM July/August 3013. These improvements can be fulfilling on the bases of object and operation supported maintenance.
Restoration of adhesive potentials of Ehrlich ascites carcinoma cells by modification of plasma membrane (1991)

A novel technique for modulating the spreading of ascites cells has been developed. Plasma membranes of Ehrlich ascites carcinoma cells were modified in two different ways: 1) biotin residues were covalently coupled to membrane components; 2) biotinylated lipid was introduced into plasma membrane. Adhesion and spreading of modified cells on avidin-coated substrates were studied and compared to those of non-modified cells. Both types of membrane alteration were shown to induce specific (biotin-dependent) interaction with immobilized avidin with resultant cell spreading. Spread cells attained epithelioid-like morphology with the formation of wide thin lamellae, focal contacts with substrate, and circular actin bundles. The process of spreading was shown to be energy-dependent: it could be blocked by metabolic inhibitors and by low temperature. Formation of extended lamellae was prevented by preincubation of cells in the presence of cytochalasin B. The effects of metabolic poisons, low temperature, and microfilament--disruptive drugs were reversible and after the restoration of physiological conditions the cells resumed the spreading process. Immunoprecipitation of biotinylated cell lysates with antiserum to cytoplasmic domain of beta 1-integrin subunit revealed a major 110 kD avidin-binding component. We conclude that lack of spreading of ascites carcinoma cells may be explained by the lack of functionally active adhesion- and spreading-competent cell-surface receptors, but may not be attributed to the defects in intracellular function or organization. Intracellular machinery of cell spreading is preserved in these ascites cells and could be turned on by cell attachment to the substrate via artificial adhesive site incorporated into plasma membrane.
Cell Surface Display of a Single-Chain Antibody for Attaching Polypeptides (1996)

To provide an efficient means of coupling proteins, peptides and other suitable moieties to cells, we have constructed a retroviral expression vector for cell surface display of a single-chain antibody (scFv) against the hapten 4-ethoxymethylene-2-phenyl-oxazo-line-5-one (phOx). The hapten phOx can be easily conjugated to primary amino and sulfhydryl groups, thus providing points of attachment for the cell surface-bound anti-phOx scFv. This universal cell coupling system could prove to be particularly useful for anchoring monoclonal antibodies for tumor targeting and to present co-stimulatory molecules and other ligands (even mixtures) at the cell surface for gene therapy.
OS9(3)-11(OS09W0089) A Comparison Between Active and Passive Piezoelectric Elements for Damage Detection in Fiber : Reinforced Composite Laminates (2003)

Beside other non-destmctive testing methods like ultrasonics, X-Ray, and thermography, acoustic emission (AE) analysis using passive piezoelectric sensors is a standard tool fbr damage detection and damage severity assessment in structures made of fiber-reinfbrced polymer-matrix composites. The standardized procedures for AE analysis usua]ly require the application of special load-time patterns. The quantitative assessment of the AE data frequently has to be based on a surnciently large empirical data base from testing composite structures under simi]ar conditions.
Graded-index thin-film stack for cladding and coupling (2016)

A graded-index multilayer thin-film stack is optimized to act as a cladding layer on top of a silicon (Si) nanowaveguide and also a collimator for chip coupling where the waveguide ends. The numerical example shows an optimized graded-index profile from 2.35 to 1.45 provides an optical coupling to the standard single-mode fiber with efficiency close to 90% while retaining tight light confinement for the Si nanowaveguide. The corresponding material realization of a graded-index profile with a Si-rich nitride SiN<sub>x</sub>/SiON/SiO<sub>2</sub> system is explored using inductively coupled plasma chemical vapor deposition, and a SiN<sub>x</sub> cladded Si waveguide is demonstrated.
Case Histories: New Horizontal Completion Designs Facilitate Development and Increase Production Capabilities in Sandstone Reservoirs (1994)

Abstract Premature water breakthrough and sand production are problems that have plagued operators worldwide in the development of sandstone reservoirs. In many cases, these difficulties have limited the productivity of sandstone reservoirs to such an extent that operators have ignored recoverable reserves, considering them to be economically unfeasible. Today, however, horizontal technology can offer operators a viable sand control completion technique to address these issues; its capabilities of reducing formation damage by decreasing production flow velocities and drawdown pressure across the production zones while reducing the water content provides solutions to many basic sand control problems. As demonstrated by the successes recently achieved using this technology, horizontal completions have dramatically changed operational outlook for both new wells and recompletions in a sandstone environment.
The heat‐shock protein 90 inhibitor 17‐allylamino‐17‐demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis (2006)

The heat-shock response (HSR), a highly conserved cellular response, is characterized by rapid expression of heat-shock proteins (HSPs), and inhibition of other synthetic activities. The HSR can attenuate inflammatory responses, via suppression of transcription factor activation. A HSR can be induced pharmacologically by HSP90 inhibitors, through activation of the transcription factor Heat Shock Factor 1 (HSF1). In the present study we characterized the effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a less toxic derivative of the naturally occurring HSP90 inhibitor geldanamycin, on glial inflammatory responses and the development of experimental autoimmune encephalomyelitis. In primary enriched glial cultures, 17-AAG dose dependently reduced lipopolysaccharide-dependent expression and activity of inducible nitric oxide synthase, attenuated interleukin (IL)-1beta expression and release, increased inhibitor of kappaB protein levels, and induced HSP70 expression. 17-AAG administration to mice immunized with myelin oligodendrocyte glycoprotein peptide prevented disease onset when given at an early time, and reduced clinical symptoms when given during ongoing disease. T cells from treated mice showed a reduced response to immunogen re-stimulation, and 17-AAG reduced CD3- and CD28-dependent IL-2 production. Together, these data suggest that HSP90 inhibitors could represent a new approach for therapeutic intervention in autoimmune diseases such as multiple sclerosis.
Clinical development of namitecan (ST1968), a novel camptothecin derivative with high antitumor activity: Phase I clinical data (2009)

2570 Background: Namitecan is a new water-soluble camptothecin analogue which showed high antitumor activity in preclinical models. Aim of this trial was to determine safety, PK profile and activity in adult patients with advanced solid tumors. Methods: The dose escalation started at 2.5 mg i.v. on days 1 and 8 of a 21 day cycle (D1, D8 Q21D) and increased according to 3+3 cohort design depending on the observed toxicity. Dose limiting toxicity (DLT) definitions were: ANC &lt;0.5x10 9 /L for &gt;5 days; PLT ≥ Grade 3 (CTC V3); grade ≥2 liver/renal toxicity not recovered by D22; any non-hematologic toxicity ≥ Grade 3; D8 dose skipping due to toxicity. Maximum tolerated dose (MTD) and recommended dose (RD) were the primary end-points. Blood and urine samples were collected at cycle 1 for PK evaluation. Results: 31 pts (11 endometrial ca., 5 CRC, 5 ovarian ca., 2 NSCLC, 8 other) have been included, with 6 dose levels evaluated (2.5; 5; 10; 15; 17.5 and 20 mg). 17.5 mg was introduced later when 2/7 DLTs at 20 mg were observed (ANC G4&gt;5days, one with D8 skipping). At 17.5mg 2/4 pts experienced DLTs (ANC G4; D8 skipped). Uncomplicated neutropenia and thrombocytopenia were the most relevant G3/4 hematological toxicities. Other toxicities were mild or moderate asthenia, fatigue and alopecia. The MTD was defined at 17.5 mg and the RD was 15 mg. Stable disease ≥ 6 cycles was recorded in 6 pts (2 stable diseases ≥ 10 cycles). PK was linear and data suggest an entero-hepatic recirculation. No metabolites were found in plasma and the product resulted poorly excreted into urine. Conclusions: The MTD and RD of D1, D8 Q21D schedule have been identified. The study will continue with the evaluation of MTD and RD of a single administration per cycle (D1 Q21D), to optimize the schedule of treatment. [Table: see text]
Robust Beamforming Design for Ultra-dense User-Centric C-RAN in the Face of Realistic Pilot Contamination and Limited Feedback (2018)

The ultra-dense cloud radio access network (UD-CRAN), in which remote radio heads (RRHs) are densely deployed in the network, is considered. To reduce the channel estimation overhead, we focus on the design of robust transmit beamforming for user-centric frequency division duplex (FDD) UD-CRANs, where only limited channel state information (CSI) is available. Specifically, we conceive a complete procedure for acquiring the CSI that includes two key steps: channel estimation and channel quantization. The phase ambiguity (PA) is also quantized for coherent cooperative transmission. Based on the imperfect CSI, we aim for optimizing the beamforming vectors in order to minimize the total transmit power subject to users' rate requirements and fronthaul capacity constraints. We derive the closed-form expression of the achievable data rate by exploiting the statistical properties of multiple uncertain terms. Then, we propose a low-complexity iterative algorithm for solving this problem based on the successive convex approximation technique. In each iteration, the Lagrange dual decomposition method is employed for obtaining the optimal beamforming vector. Furthermore, a pair of low-complexity user selection algorithms are provided to guarantee the feasibility of the problem. Simulation results confirm the accuracy of our robust algorithm in terms of meeting the rate requirements. Finally, our simulation results verify that using a single bit for quantizing the PA is capable of achieving good performance.
Towards using nanoelectrospray for evaporative heat transfer enhancement (2017)

For a number of demanding applications, the performance of electronic devices is hampered by the inability to remove generated heat at a sufficient rate to increase transistor density or operating frequency without exceeding thermal limits. Two-phase cooling, in particular thin film evaporation, exploits the latent heat of phase change to provide an effective means for high heat flux dissipation while keeping device junction temperatures nearly constant over a range of heating loads. Delivering a coolant at a precise location on the heated surface and forming a thin film needed for efficient evaporation from a free liquid surface are key requirements for using evaporative cooling for thermal management of spatially non-uniform heat fluxes. The electrospray process enables production and delivery of micro to nanoscale electrically charged droplets towards the heated surface to produce the liquid films, and therefore it has a potential to be a promising method for evaporative cooling. A relatively low power consumption needed to generate the electrospray provides further benefits in terms of energy efficiency as compared to conventional mechanically pumped liquid spray approaches. We report on experimental observations of electrosprayed droplet impingement, coalescence, and film formation on a heated ITO (Indium Tin Oxide) surface acting as an optically transparent heating element, focusing primarily on visualization and mapping of the impacting spray-jet behavior and its impact on the resulting film thickness and shape, which directly affect an expected performance of evaporative cooling.
Note: Thermally removable epoxy adhesives incorporating thermally reversible diels-alder adducts (2003)

Thermally reversible adhesives are prepared through the reaction of aliphatic diamines and a diepoxy compound containing two Diels-Alder adducts. The diepoxy compound is formed via the Diels-Alder reaction between two epoxy-containing furans and a bismaleimide. The adhesive displays a T g of m 40°C and a constant shear modulus up to approximately 90°C. At temperatures exceeding 90°C the retro Diels-Alder reaction occurs, which leads to a significant loss in modulus. The loss of modulus is reversible with temperature. A thermally reversible adhesive is proposed based upon the loss of modulus at an elevated temperature, i.e., adhesives bonds are easily broken at elevated temperature where the modulus is low. Keywords: EpoxyDiels-AlderDiamineAdhesionThermally ReversibleThermally Removable
Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface (2008)

Brain metastases are a common feature of malignant melanoma and are associated with poor prognosis. Melanotransferrin (MTf), one of several antigens associated with the surface of melanoma cells, has been demonstrated to promote cell invasion. In this study, we investigated the role of membrane-bound MTf in several of the steps leading to the development of melanoma brain metastasis. Our results indicated that MTf-positive cells were detected in the brains of nude mice injected intravenously with human melanoma SK-Mel 28 cells. Moreover, administration of a single dose of a monoclonal antibody (L235) directed against human MTf significantly reduced the development of human melanoma brain metastases in nude mice. The ability of melanoma cells to cross the blood-brain barrier (BBB) in vitro is correlated with their MTf expression levels at the cell surface. Overall, our results indicated that membrane-bound MTf is a key element in melanoma cell transmigration across the BBB and subsequent brain metastasis. Thus, these data suggest MTf as an attractive target and demonstrate the therapeutic potential of an anti-MTf mAb for preventing metastatic melanoma.