gebhart/patrepeval huggingface dataset:
In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium (2008)

Calpain activation is linked to the cleavage of several cytoskeletal proteins and could be an important contributor to the loss of cardiomyocytes and contractile dysfunction during cardiac pressure overload (PO). Using a feline right ventricular (RV) PO model, we analyzed calpain activation during the early compensatory period of cardiac hypertrophy. Calpain enrichment and its increased activity with a reduced calpastatin level were observed in 24- to 48-h-PO myocardium, and these changes returned to basal level by 1 wk of PO. Histochemical studies in 24-h-PO myocardium revealed the presence of TdT-mediated dUTP nick-end label (TUNEL)-positive cardiomyocytes, which exhibited enrichment of calpain and gelsolin. Biochemical studies showed an increase in histone H2B phosphorylation and cytoskeletal binding and cleavage of gelsolin, which indicate programmed cardiomyocyte cell death. To test whether calpain inhibition could prevent these changes, we administered calpeptin (0.6 mg/kg iv) by bolus injections twice, 15 min before and 6 h after induction of 24-h PO. Calpeptin blocked the following PO-induced changes: calpain enrichment and activation, decreased calpastatin level, caspase-3 activation, enrichment and cleavage of gelsolin, TUNEL staining, and histone H2B phosphorylation. Although similar administration of a caspase inhibitor, N-benzoylcarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VD-fmk), blocked caspase-3 activation, it did not alleviate other aforementioned changes. These results indicate that biochemical markers of cardiomyocyte cell death, such as sarcomeric disarray, gelsolin cleavage, and TUNEL-positive nuclei, are mediated, at least in part, by calpain and that calpeptin may serve as a potential therapeutic agent to prevent cardiomyocyte loss and preserve myocardial structure and function during cardiac hypertrophy.
PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data (2005)

We describe a tool that produces summary statistics and basic quality assessments for gene-mapping data, accommodating either pedigree or case-control datasets. Our tool can also produce graphic output in the PDF format.
Dactylitis in a child with sickle cell trait. (1985)

Dactylitis commonly occurs in patients with homozygous hemoglobin S disease (sickle cell anemia), sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. A case is reported of dactylitis associated with sickle cell trait, a very rare occurrence. It may be that in this patient the disorder was secondary to severe diarrhea and dehydration.
Survival-Related Profile, Pathways, and Transcription Factors in Ovarian Cancer (2009)

Our study provides new clues to genes, pathways, and transcription factors that contribute to the clinical outcome of serous ovarian cancer and might be exploited in designing new treatment strategies.
Measurement of glucose in plasma, with use of immobilized glucose oxidase and peroxidase. (1976)

We describe a novel fluorometric technique for simple, rapid, and economical assay of glucose by use of immobilized glucose oxidase and peroxidase. A cylindrical magnetic stirrer was specially designed to hold the immobilized enzymes firmly and to allow the reaction minzymic transformation quickly. Blood plasma can be assayed directly with no pretreatment. Ascrobic acid, uric acid, and creatinine in concenctrations of 0.25, 0.25, and 0.2 g/liter, respectively, did not interfere. The linearity of the assay was extended to 4.0 g of glucose concentrations. Results by our technique and by the otoluidine or hexokinase methods agreed well. The immobilized enzymes are stable for several months and can be used for several hundred highly accurate and reproducible assays.
Scale Inhibition in Wellbores (1994)

Abstract Adsorption is considered the primary mechanism of scale inhibitor retention during squeeze treatments of sandstone formations. Steps are often taken to avoid inhibitor precipitation for fear of formation damage. In limestone and dolomite formations, phosphonic acid inhibitors are deliberately allowed to react with the formation and precipitate as the slightly soluble calcium salt. This can result in longer scale protection times. Even neutralized inhibitors react with limestone to form precipitates. This paper investigates the factors that affect the inhibitor precipitation and retention in carbonate formations. Core tests show an absence of damage during inhibitor injection but good retention. A slow rate of inhibitor return is observed during brine backflow. In formation brines containing Ca++, inhibitor dissolution is slowed by the common ion effect.
Manufacturing Resource Optimization Deployment for Manufacturing Execution System (2008)

Manufacturing execution system (MES) is put forward by advanced manufacturing research, and it's the management information system for workshop hierarchy, which is located between planning management system and industry controlling system. How to manage, share and allocate manufacturing resource is key problem for MES. The paper firstly introduces requirements of manufacturing resource allocation for MES application, and analyzes plant manufacturing task description and equipment resource model. And then studies manufacturing resource optimization deployment problem based on grey relation theory and ant colony algorithm. Secondly, manufacturing task is divided into series of working procedure in time order by technologic planning. Secondly, considerable machines are selected in terms of multi-hierarchy grey relation coefficient at each working procedure node to reduce the size of problem. Lastly, manufacturing resource selecting path is decided by making use of ant colony algorithm in light of grey relation degree.
Professional Apache (1999)

From the Publisher:
This is the first book to cover Apache versions 1.3.6 and 1.3.9
and the first book to cover them in such an accessible, experience based style.
Assessment of Gamma-Ray-Spectra Analysis Method Utilizing the Fireworks Algorithm for Various Error Measures (2018)

The analysis of measured data plays a significant role in enhancing nuclear nonproliferation mainly by inferring the presence of patterns associated with special nuclear materials. Among various types of measurements, gamma-ray spectra is the widest utilized type of data in nonproliferation applications. In this chapter, a method that employs the fireworks algorithm (FWA) for analyzing gamma-ray spectra aiming at detecting gamma signatures is presented. In particular, FWA is utilized to fit a set of known signatures to a measured spectrum by optimizing an objective function, where non-zero coefficients express the detected signatures. FWA is tested on a set of experimentally obtained measurements optimizing various objective functions—MSE, RMSE, Theil-2, MAE, MAPE, MAP—with results exhibiting its potential in providing highly accurate and precise signature detection. Furthermore, FWA is benchmarked against genetic algorithms and multiple linear regression, showing its superiority over those algorithms regarding precision with respect to MAE, MAPE, and MAP measures.
Expression of the Three Unlinked Isocoding Actin Genes of Physarum polycephalum (1988)

The actin gene family in Physarum polycephalum contains four unlinked loci: ardA, ardB, ardC, and ardD. The ardA locus is complex and probably contains two genes which we designated ardA2-7 and ardA2-17. cDNA clones corresponding to the ardB and ardC loci were isolated. Nucleic acid sequencing showed that these two cDNAs coded for the only abundant form of Physarum actin, which is 96% homologous to human gamma-cytoplasmic actin. The ardA2-17 gene also codes for this same actin protein (Nader et al., Gene 48, 133-144, 1986). The coding regions of ardB and ardC differ by 15 nucleotides. A comparison of the ardB and ardC sequences with ardA2-17 showed 73 and 77 nucleotide substitutions, respectively, in the coding regions. The noncoding regions of these three sequences were not homologous to each other or to the noncoding regions of actin genes from other organisms. Southern genomic hybridizations indicated that the ardA2-7 and ardD genes have weak sequence similarities to the three isocoding actin genes and thus form a different subclass of the family. Northern hybridizations showed that the ardB and ardC transcripts varied in abundance but were present in all the developmental stages. No ardA2-17 transcripts were seen. The relative abundance of the ardB and ardC transcripts was measured in amoebae and plasmodia by S1 nuclease protection and dot hybridization assays. A ratio of approximately 3:1 for ardC versus ardB was found for both stages. P. polycephalum is the first organism shown to contain three unlinked isocoding actin genes, of which at least two are expressed.
5. Production Simulations (2011)

Introduction Numerical simulations were done by Tierra Geophysical, now part of Landmark Graphics Corporation. SEAM did not specify a specific approach to perform numerical simulations. Instead, SEAM developed quality requirements for the simulations and allowed vendors to meet those requirements using any numerical approach, whose specifics may remain unknown to SEAM. Hence, this chapter does not attempt to describe the specifics of the simulation computation. Rather, it focuses on • run parameters so that the data can be reproduced; • artifacts from postsimulation filtering to apply the SEAM far-field wavelet; • global amplitude scaling process; • use of ghost source and receivers so that absorbing upper surface data have the same wavelet as the free surface data; • the degree of variation in the data caused by factors such as a change to the simulation code, use of multiple compute clusters, and elimination of numerical problems that occurred on a very small percentage of the shots; and • problems that occurred, and how they were identified and corrected.
A novel dye-linked alcohol dehydrogenase activity present in some Gram-positive bacteria (1991)

An assay was developed which allowed reproducible detection of methanol oxidation by cell free extracts of methanol-grown Amycolatopsis methanolica. The dye-linked activity was only observed when high concentrations of phosphate or sulphate salts were applied in the assay. The specific activity strongly increased when raising the amount of cell free extract in the assay. From the large number of electron acceptors tested only the tetrazolium dyes MTT and INT showed significant activity. Activity was observed with primary as well as secondary alcohols. A similar activity was found in ethanol-grown A. methanolica, Rhodococcus erythropolis and Rhodococcus rhodochrous, but not in other bacteria tested. The identity and possible involvement in alcohol oxidation of this novel dye-linked activity is discussed.
A Novel Three-Phase PFC Rectifier Using a Harmonic Current Injection Method (2008)

This paper proposes a novel circuit topology for a three-phase power factor correction (PFC) rectifier using a harmonics current injection method. In consideration of lower cost, the harmonics injection method is more suitable than a conventional six-arm pulse width modulation (PWM) rectifier. The harmonics injection current is simply generated by only one switching leg. As a result, the proposed circuit has the advantage of only two switches. An optimal injection current is achieved in order to obtain an input current of sinusoidal waveforms. This paper discusses the basic operation and optimal design method for the proposed circuit. In addition, the validity of the proposed circuit is confirmed by simulation and experimental results. An input current of almost sinusoidal waveform was obtained and an input current total harmonic distortion (THD) of 8.5% was obtained at a load of approximately 1 kW.
A suggestive interface for image guided 3D sketching (2004)

We present an image guided pen-based suggestive interface for sketching 3D wireframe models. Rather than starting from a blank canvas, existing 2D images of similar objects serve as a guide to the user. Image based filters enable attraction, smoothing, and resampling of input curves, and allows for their selective application using pinning and gluing techniques. New input strokes also invoke suggestions of relevant geometry that can be used, reducing the need to explicitly draw all parts of the new model. All suggestions appear in-place with the model being built, in the user's focal attention space. A curve matching algorithm seamlessly augments basic suggestions with more complex ones from a database populated with previously used geometry. The interface also incorporates gestural command input, and interaction techniques for camera controls that enable smooth transitions between orthographic and perspective views.
Direct vs Delayed Triplet Energy Transfer from Organic Semiconductors to Quantum Dots and Implications for Luminescent Harvesting of Triplet Excitons (2020)

Hybrid inorganic-organic materials such as quantum dots (QDs) coupled with organic semiconductors have a wide range of optoelectronic applications, taking advantage of the respective materials' strengths. A key area of investigation in such systems is the transfer of triplet exciton states to and from QDs, which has potential applications in the luminescent harvesting of triplet excitons generated by singlet fission, in photocatalysis and photochemical upconversion. While the transfer of energy from QDs to the triplet state of organic semiconductors has been intensely studied in recent years, the mechanism and materials parameters controlling the reverse process, triplet transfer to QDs, have not been well investigated. Here, through a combination of steady-state and time-resolved optical spectroscopy we study the mechanism and energetic dependence of triplet energy transfer from an organic ligand (TIPS-tetracene carboxylic acid) to PbS QDs. Over an energetic range spanning from exothermic (-0.3 eV) to endothermic (+0.1 eV) triplet energy transfer we find that the triplet energy transfer to the QD occurs through a single step process with a clear energy dependence that is consistent with an electron exchange mechanism as described by Marcus-Hush theory. In contrast, the reverse process, energy transfer from the QD to the triplet state of the ligand, does not show any energy dependence in the studied energy range; interestingly, a delayed formation of the triplet state occurs relative to the quantum dots' decay. Based on the energetic dependence of triplet energy transfer we also suggest design criteria for future materials systems where triplet excitons from organic semiconductors are harvested <i>via</i> QDs, for instance in light emitting structures or the harvesting of triplet excitons generated <i>via</i> singlet fission.
Spectral and polarization modulation of quantum dot emission in a one-dimensional liquid crystal photonic cavity (2012)

We demonstrate spectral and polarization modulation of chemically synthesized core-shell CdSe/ZnS quantum dots (QDs) embedded in a one-dimensional photonic cavity formed by a cholesteric liquid crystal (CLC) matrix. A Cano-wedge cell varies the pitch of the CLC leading to the formation of Grandjean steps. This spatially tunes the photonic stop band, changing the resonance condition and continuously altering both the emission wavelength and polarization state of the QD ensemble. Using high resolution spatially and spectrally resolved photoluminescence measurements, we find that the emission is elliptically polarized and that the tilt of the ellipse, while dependent on the emission wavelength, additionally varies with distance across the Grandjean steps. This work opens up the possibility of designing new QD based optical devices, such as tunable single photon sources, where spatial control of wavelength and polarization of the embedded QDs would allow great flexibility and added functionalities.
Studies on the Lower Explosion Limit of Coal Dust Clouds (Part II) (1985)

A simiiar technique to that used inconsidering the expiosion limit of coaidust-rock dust mixtures was used to investigate the influence of ash content on the lower explosion limit concentration of coals. A resultant equation is Ea.(10). where CL [g/m3] is the lower explosion limit dust concen tration of acoal with As [%] of ash content, CL, 0 the lower explosion limit dust concentration of an ash-free coal made from the coal with As pct ash, As, m the maximum ash content effective for explosion suppressicn, and Cst, 0=250g/m3. Accuracy of Eq.(10) was tested by comparing with experimental data obtained by Ishiharna et al. This is illustrated in Fig.1, which shows a very good agreement. By rearranging Eq.(10), we obtain Eq.(11) which can be used to estimate the lower explosion limit concentration of the ash-free coal, CL, 0 from that experimentally obtained with an ash-containing coal, CL.On the basis of the results obtained by a theoretical calculation of lower explosion limit concentrations of coal dust clouds reported in the previous paper, a simplified method of estimation of lower explosion limit concentrations of coals was developed. These are Eqs.(13) to (16). Then experimental data were used for comparison. This is shown in Fig.4. Evaluation of the influence of ash content on the lower explosion limit concentration in the simplified estimation method of Eqs.(13) to (16) and that in Eq.(10) are shown in Fig. 5. From this figure, it may be concluded that the simplified estimation method can be applicable for coals, the ash content of which is less than roughly 30 pct.
Adaptive Multi-Model Switching Predictive Active Power Control Scheme for Wind Generator System (2020)

To deal with the randomness and uncertainty of the wind power generation process, this paper proposes the use of the clustering method to complement the multi-model predictive control algorithm for active power control. Firstly, the fuzzy clustering algorithm is adopted to classify actual measured data; then, the forgetting factor recursive least square method is used to establish the multi-model of the system as the prediction model. Secondly, the model predictive controller is designed to use the measured wind speed as disturbance, the pitch angle as the control variable, and the active power as the output. Finally, the parameters and measured data of wind generators in operation in Western China are adopted for simulation and verification. Compared to the single model prediction control method, the adaptive multi-model predictive control method can yield a much higher prediction accuracy, which can significantly eliminate the instability in the process of wind power generation.
Ein molekularer Blick auf die Heterogenität in Gläsern (2012)

Das Problem des Glasübergangs gibt seit über einem Jahrhundert Rätsel auf. Eine Schwierigkeit dabei ist die Quantifizierung der Struktur eines inhomogenen Systems, wie z. B. Hüttenkäse, selbst wenn „Quark“ und „Molke“ aus dem gleichen Material bestehen. Für die Erforschung des Konfigurationsraumes dieser komplexen Systeme benötigt man neue Typen von Experimenten auf der Basis vieler unterschiedlicher lokaler Sonden.
Devices for Administering Ventilation at Birth: A Systematic Review (2021)

Resuscitation with a TPR compared with an SIB reduces the duration of PPV and risk of bronchopulmonary dysplasia. A strong recommendation cannot be made because of the low certainty of evidence. There is insufficient evidence to determine the effectiveness of positive end-expiratory pressure valves when used with SIBs.
Electrically Excited Synchronous Motor Three-Level DTC_SVM Control Based on Novel Flux Observer (2010)

The accurate observer and effective control of the stator flux for electrically excited synchronous motor, has a significant sense to the performance improvement of direct torque control system. For this, a novel full-order closed-loop stator flux estimator suitable for full speed range was put forward and analyzed detailed in this paper, it pointed out that the estimator was composed of two estimator models, i.e. current model and voltage model, and they switched smoothly because of their properties of filters. Applying the simplified three-level SVPWM algorithm to direct torque control (DTC), can not only implement the accurate compensation for the torque and flux linkage error but also guarantee for maintaining a constant frequency of power device. Furthermore, a novel method of voltage estimate for the three-level power inverter is advanced based on the simplified SVPWM strategy. Experiment results demonstrated that the proposed electrically excited synchronous motor DTC_SVM system based on full-order closed-loop stator flux estimator has excellent control property.
Saline hydrides and superbases. 14. Rapid elimination reactions of vinyl ethers and sulfides with potassium 3-aminopropylamide. Vinyl sulfides as acetylene equivalents (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSaline hydrides and superbases. 14. Rapid elimination reactions of vinyl ethers and sulfides with potassium 3-aminopropylamide. Vinyl sulfides as acetylene equivalentsCharles Allan BrownCite this: J. Org. Chem. 1978, 43, 15, 3083–3084Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/jo00409a042https://doi.org/10.1021/jo00409a042research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evolution in the influenza A H3 stalk – a challenge for broad-spectrum vaccines? (2013)

Recently, a number of broad-spectrum human antibodies binding to the stalk region of influenza A haemagglutinin (HA) have been isolated. As this region tends to develop substitutions at a slower rate than other regions of HA, a vaccine eliciting such antibodies could have a longer effective life. But this begs a question: is the stalk resistant to change even in the face of evolutionary pressure? In this paper, we analysed the known epitopes in the H3 stalk and, utilizing a collection of 3440 sequences, present a novel approach for detecting putative B-cell epitopes in regions such as this, in which mutations occur infrequently. We concluded that there have been periods of activity in the stalk that are consistent with the evolution of antigenic escape. This work casts light on the presence of stalk-binding antibodies in the population as a whole and, through the analysis of antigenically active regions in the stalk, may contribute to the identification of epitopes that are refractive to change and hence useful for vaccine development.