gebhart/patrepeval huggingface dataset:
Patient Monitoring Technology: Friend or Foe? (2000)

This symposium presents four viewpoints on the role of patient monitoring technology in supporting care-provider activity in the medical domain. First, observations of care providers in the critical care setting provide an overview of the current state of affairs and the style of interaction that characterizes current technology. Second, task analysis and interface design techniques from a medical device manufacturer are reviewed as an example of how the medical device industry is incorporating human factors considerations into current design decisions. Third, an innovative approach using an ecological, object-based display is offered and systematic tests of its efficacy are presented as alternatives to traditional displays of vital signs for patient monitoring. Lastly, a strong critique of the current philosophy of monitoring technology is presented. The diverse viewpoints of the contributors provide evidence regarding the strengths, weaknesses and possibilities for improvement of patient monitoring technology.
Electrical characterization of leaf-based wires & supercapacitors (2019)

Electronic waste (e-waste) is a growing problem in the world due to increasing consumption and subsequent discarding of electronic devices. One of the ways to address this problem is to develop electronics made up of biodegradable components. Leaves are readily available, biodegradable and can be found with various types of architecture of the vascular conduits within. We investigated the possibility of developing electronic components based on leaves of a monocotyledon plant by introducing a conducting polymer inside the vascular conduits. We were able to construct conducting wires in those conduits extending to centimeters in length within a leaf. Furthermore, we were able to demonstrate the construction of a supercapacitor within a leaf by using the conducting conduits as electrodes. These results suggest the possibility of constructing embedded electronic components within leaves which may provide an alternative towards the development of biodegradable electronics.
Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy (2000)

Cardiac hypertrophy is characterized by both remodeling of the extracellular matrix (ECM) and hypertrophic growth of the cardiocytes. Here we show increased expression and cytoskeletal association of the ECM proteins fibronectin and vitronectin in pressure-overloaded feline myocardium. These changes are accompanied by cytoskeletal binding and phosphorylation of focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, c-Src at Tyr-416, recruitment of the adapter proteins p130(Cas), Shc, and Nck, and activation of the extracellular-regulated kinases ERK1/2. A synthetic peptide containing the Arg-Gly-Asp (RGD) motif of fibronectin and vitronectin was used to stimulate adult feline cardiomyocytes cultured on laminin or within a type-I collagen matrix. Whereas cardiocytes under both conditions showed RGD-stimulated ERK1/2 activation, only collagen-embedded cells exhibited cytoskeletal assembly of FAK, c-Src, Nck, and Shc. In RGD-stimulated collagen-embedded cells, FAK was phosphorylated only at Tyr-397 and c-Src association occurred without Tyr-416 phosphorylation and p130(Cas) association. Therefore, c-Src activation is not required for its cytoskeletal binding but may be important for additional phosphorylation of FAK. Overall, our study suggests that multiple signaling pathways originate in pressure-overloaded heart following integrin engagement with ECM proteins, including focal complex formation and ERK1/2 activation, and many of these pathways can be activated in cardiomyocytes via RGD-stimulated integrin activation.
Blood Pressure Response to Caffeine Shows Incomplete Tolerance After Short-Term Regular Consumption (2004)

Caffeine acutely raises blood pressure (BP). The clinical significance of this effect depends on whether BP responses persist in persons who consume caffeine on a daily basis. Accordingly, the ability of caffeine to raise BP after 5 days of regular daily intake was tested in a randomized controlled trial. Individual differences in tolerance formation were then examined. Men (n=49) and women (n=48) completed a double-blind, crossover trial conducted over 4 weeks. During each week, subjects abstained for 5 days from dietary caffeine and instead used capsules totaling 0 mg, 300 mg, and 600 mg of caffeine per day in 3 divided doses. On day 6, in the laboratory, they used capsules with either 0 mg or 250 mg of caffeine at 9:00 am and 1:00 pm. Systolic/diastolic BP increases as a result of 250 mg of caffeine remained significant (P<0.006/0.001) at all levels of previous daily consumption. Individual difference comparisons found that although half the subjects had complete loss of systolic and diastolic BP responses to the challenge doses, the other half showed no loss in BP response, even after using 600 mg of caffeine per day for the previous 5 days (F >7.90, P <0.001). The sexes did not differ in degree of tolerance formation. Daily caffeine consumption failed to eliminate the BP response to repeated challenge doses of caffeine in half of the healthy adults who were tested. Caffeine may therefore cause persistent BP effects in persons who are regular consumers, even when daily intake is at moderately high levels.
Micro-patterned surface for efficient capturing of circulating tumor cells (2012)

This work aims to design, fabricate, and characterize a micro-patterned surface that will be integrated into microfluidic devices to enhance particle and rare cell capture efficiency. Capture of ultralow concentration of circulating tumor cells in a blood sample is of vital importance for early diagnostics of cancer diseases. Despite the significant progress achieved in development of cell capture techniques, the enhancement in capture efficiency is still limited and often accompanied with drawbacks such as low throughput, low selectivity, pre-diluting requirement, and cell viability issues. The goal of this work is to design a biomimetic surface that could significantly enhance particle/cell capture efficacy through computational modeling, surface patterning, and microfluidic integration and testing. A PDMS surface with microscale ripples is functionalized with epithelial cell adhesion molecule (EpCAM) antibody to capture prostate cancer PC3 cells. Our microfluidic chip with micropatterns has shown significantly higher cell capture efficiency and selectivity compared to the chips with plane surface or classical herringbone-grooves.
A Seed-GUS-Expression enhancer-trap library for germination research. (2007)

Enhancer-trap lines are used to identify tissue- and stage-specific gene expression. An Arabidopsis (Arabidopsis thaliana (L.) Heynh.) enhancer-trap population from the Arabidopsis Biological Resource Center (ABRC), Ohio, USA, has been screened for β-glucuronidase (GUS) expression in germinating seeds. Application of these enhancer-trap lines for functional analysis of seed germination-associated genes has led to the successful identification of a GATA zinc finger transcription factor crucial for seed germination. A Seed-GUS-Expression enhancer-trap library was donated to the ABRC (stock no. CS24362-CS24480), and is now available to the international seed research community. This library can be used for seed germination research by combining northern blotting and reverse transcription polymerase chain reaction (RT-PCR) expression analysis with functional analysis using knockout plants. Here, an overview of the procedures for utilizing the enhancer-trap library for germination research including some potential pitfalls and hints for troubleshooting experiments is presented.
Kinetics of Peptide Synthesis by the Leucyl-tRNA Synthetase fromBacillus stearo thermophilus (1986)

Journal Article Kinetics of Peptide Synthesis by the Leucyl-tRNA Synthetase from Bacillus stearo thermophilus Get access Munehiko Dombou, Munehiko Dombou Research and Development Center, Unitika Ltd., 23 Kozakura, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Nakajima, Hiroshi Nakajima To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Senji Kitabatake, Senji Kitabatake Research and Development Center, Unitika Ltd., 23 Kozakura, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Kosuke Tomita, Kosuke Tomita Research and Development Center, Unitika Ltd., 23 Kozakura, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Kajzutomo Imahori Kajzutomo Imahori Tokyo Metropolitan Institute of Gerontology, 35–2 Sakaecho, Itabashi-ku, Tokyo 173, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 12, 1 December 1986, Pages 2967–2972, https://doi.org/10.1080/00021369.1986.10867874 Published: 01 December 1986 Article history Received: 12 February 1986 Published: 01 December 1986
α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease (2017)

Parkinson's disease (PD) is a progressive neurodegenerative disease with devastating clinical manifestations. In PD, neuronal death is associated with intracellular aggregates of the neuronal protein α-synuclein known as Lewy bodies. Although the cause of sporadic PD is not well understood, abundant clinical and pathological evidence show that misfolded α-synuclein is found in enteric nerves before it appears in the brain. This suggests a model in which PD pathology originates in the gut and spreads to the central nervous system via cell-to-cell prion-like propagation, such that transfer of misfolded α-synuclein initiates misfolding of native α-synuclein in recipient cells. We recently discovered that enteroendocrine cells (EECs), which are part of the gut epithelium and directly face the gut lumen, also possess many neuron-like properties and connect to enteric nerves. In this report, we demonstrate that α-synuclein is expressed in the EEC line, STC-1, and native EECs of mouse and human intestine. Furthermore, α-synuclein-containing EECs directly connect to α-synuclein-containing nerves, forming a neural circuit between the gut and the nervous system in which toxins or other environmental influences in the gut lumen could affect α-synuclein folding in the EECs, thereby beginning a process by which misfolded α-synuclein could propagate from the gut epithelium to the brain.
Metal-Nanoparticles Based Electroanalysis (2002)

A general view of the electroanalytical applications of metal-nanoparticles in the last decade is discussed in this review. The electrocatalytical properties of various metal-nanoparticles, the employment of nanoparticles in electrochemical sensors and the use of colloidal gold as electrochemical label (no other metal nanoparticle was found to act as a label in electrochemistry) are described. Also, a description of the fabrication and electrochemical characterization of metal-nanoparticle modified electrodes is given. Finally, due to its growing importance, semiconductor-nanoparticle modified electrodes are described, although they can not be strictly considered as electroanalytical devices.
Loop Plant Modeling: A Model of Cable Pairs Added at the Main Frames for a Large Entity (1978)

In estimating annual construction budgets and work forces required for a large entity, such as an operating company, it is desirable to know the total annual number of cable pairs to be added at the main frames in all of the feeder routes in the entity. These pairs are the result of many independent relief decisions made in the individual feeder routes. A model is presented which relates the total annual number of cable pairs added at the main frames to aggregate relief timing and sizing design parameters, an aggregate demand forecast and the total assigned and available pairs at the main frames in all of the routes in the entity. Because the model does not require individual route data or specific relief projects, it can be used as a “top-down” check on the “bottom-up” requirements determined by aggregating a list of identified relief projects. It is also useful for estimating cable pair requirements when specific relief projects are not yet identified.
Massenhaftes Auftreten von Mykotoxikosen im Komitat Hajdu‐Bihar: Mass Incidence of Mycotoxicoses in Hajdu‐Bihar County (1980)

Zusammenfassung: In dem von Verfassern beschriebenen Fall wurden durch Stachybotrys alternans teils durch Einatmung der Pilze, teils durch unmittelbaren Kontakt mit der Haut und der Schleimhaut Mykotoxikosen hervorgerufen. Die Umstände der Erkrankung, daß sie auf einmal und plötzlich aufgetreten ist, sowie die beobachteten Symptome ließen keinen Zweifel darüber, daß es sich um eine Massen‐Mykotoxikose handelt. Diese Hypothese wurde durch die Angaben und Züchtungsergebnisse bestatigt, die bei der an Ort und Stelle durchgeführten Untersuchungen erhalten wurden. Es wird darauf aufmerksam gemacht, daß schimmeliges Streu nicht nur bei Tieren, sondern auch bei Menschen Erkrankungen verursachen kann. Bisher wurde keine sich auf das Vorkommen von humanen Fällen beziehende Veröffentlichung im humanmedizinischen Schrifttum gefunden. Summary: The authors report a mass occurence of mycotoxicoses as caused by Stachybotrys alternans partly by inhalung fungi, partly by their direct contact with skin or mucous membranes. The circumstances, the sudden and simultaneous outbreak of the disease, as well as its symptoms made it clear that the disease was mycotoxicoses. This hypothesis was justified by examining the scene and the sick people, and by the results of cultivation. The authors draw attention to the fact that mildewy litter and fodder can be the cause of the disease not only among animals, but men too. Medical reference has had no reference so far conderning cases where man is involved.
Distribution of Long and Short Branches in Low-Density Polyethylenes (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDistribution of Long and Short Branches in Low-Density PolyethylenesE. P. Otocka, R. J. Roe, M. Y. Hellman, and P. M. MugliaCite this: Macromolecules 1971, 4, 4, 507–512Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/ma60022a029https://doi.org/10.1021/ma60022a029research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stable Recombinant Invasion Plasmid Antigen C (IpaC)-Based Single Dose Nanovaccine for Shigellosis (2022)

Shigellosis, caused by the bacteria <i>Shigella</i>, is the leading cause of bacterial diarrhea and the second leading cause of diarrheal death among children under the age of five. Unfortunately, <i>Shigella</i> strains have acquired resistance to antibiotics, and a commercial vaccine is yet to be available. We have previously demonstrated that <i>Shigella dysenteriae</i> serotype 1 (Sd1)-based recombinant, stabilized, "invasion plasmid antigen C" (IpaC; 42 kDa) protein can induce robust immune responses in BALB/c mice against a challenge of a high dose of heterologous <i>Shigella</i> when immunized via three intranasal doses of IpaC without an adjuvant. In this work, in order to reduce the frequency of dosing and increase possible patient compliance, based on our previous screening, the minimum protective dose of stabilized IpaC (20 μg) was encapsulated in biodegradable polymeric poly(lactide-<i>co</i>-glycolide) nanoparticles (∼370 nm) and intranasally administered in BALB/c mice in a single dose. Interestingly, a single intranasal dose of the developed vaccine particles encapsulating only 20 μg of Sd1 IpaC led to a temporal increase in the antibody production with an improved cytokine response compared to free IpaC administered three times as described in our previous report. Upon intraperitoneal challenge with a high dose of heterologous <i>Shigella flexneri</i> 2a (common in circulation), the immunized animals were protected from diarrhea, lethargy, and weight loss with ∼67% survival, while all the control animals died by 36 h of the challenge. Overall, the developed nanovaccine could be explored as a potential noninvasive, cross-protective, single-dose, single-antigen <i>Shigella</i> vaccine amenable for scale-up and eventual mass immunization.
HEIDATAPROVIT - EIN UNIVERSELLES SOFTWARE TOOL ZUR AUSWERTUNG BIOMEDIZINISCHER DATENSÄTZE (2002)

Evaluation of large sets of biomedical data can be divided into three universal stages: 1. archiving of clinical data together with data obtained from measurements, 2. processing of numerical data using signal processing algorithms and 3. visualizing the results. In this paper a software is presented which tightly integrates a data base under MS Access and the possibilities for data processing and visualization offered by Matlab. This software tool provides an interface between a data base containing large sets of biomedical data and an extensible pool of evaluation and visualization procedures. It can serve both as an instrument for data processing in clinical routine and an important component for evaluation of measurement data in any medical research project.
Crystal structure of 3,8-di-tert-butyl-4,9,10-trimethoxyl- methyl-dibenzo[b,d]pyran-6-thione, C6H(OCH3)2[C(CH3)3]CSO(C6H)(CH3)(OCH3)[C(CH3)3] (2000)

C25H32O4S, monoclinic, P\2\lc\ (No. 14), a = 13.704(1) , b = 10.530( 1) , c = 16.248( 1) , = 92.37( 1), V = 2342.6 3 , Z = 4, R gt (F) = 0.062, wR(F) = 0.058, T= 293 K.
<title>Analysis of current spreading and series resistance in GaAs/AlGaAs proton-implanted top-surface-emitting lasers</title> (1994)

We obtain numerical results for the injection current in the active region and the total series electrical resistance of proton-implanted top-surface-emitting lasers with top annular contact. We investigate the variation of the resistance and the current uniformity over a range of values of parameters such as the number of periods in the p-type top spreading region, the active region radius and the specific contact resistance. Approximate analytical expressions are also obtained for the injection current in the confinement region and the agreement between analytical and numerical results is investigated for varying active region radius values.
Conflict Between Energy, Stability, and Robustness in Production Schedules (2017)

A systematic method to evaluate the conflict between robustness, stability, and energy consumption is proposed in this paper. Energy optimization is combined with robust scheduling techniques to analyze the tradeoff. In rescheduling, slack is often used to protect a schedule from disruptions. However, results from the literature on energy minimization show that a reduction in energy consumption is achieved by extending the execution time of operations. Thus, slack in schedules is diminished on behalf of longer execution times. The proposed method, which quantitatively shows this conflict, is based on a multiobjective optimization formulation where efficient computation of the involved criteria is developed. This includes a convex surrogate stability measure that makes it possible to evaluate different operation sequences by a mixed-integer nonlinear programming formulation. Previous works connecting the two research fields use simulation for analyzing the impact of disruptions in order to generate robust production schedules. Our results show that an increase in energy efficiency comes at a cost of reducing stability and robustness and hence becoming more sensitive to disruptions.
Hydrodynamique et aire interfaciale des écoulements gaz-liquide à co-courant vers le bas en lit fixe: influence de la nature du liquide. (1980)

International audience
“Fat Shadows” From DXA for the Qualitative Assessment of Lipodystrophy: When a Picture Is Worth a Thousand Numbers (2018)

Fat shadows provided sufficient qualitative information to infer clinical phenotype and differentiate these patients from appropriate control subjects. We propose that this method could be used to support the diagnosis.
Numerical analysis of the packed bed TES system integrated into the first parabolic trough CSP pilot-plant using air as heat transfer fluid (2018)

Single-tank thermal energy storage (TES) systems represent not only a valuable alternative to the most commonly exploited two-tank configuration in conventional concentrating solar power (CSP) plants, but also the most suitable solution for air-based solar systems. The first parabolic trough CSP pilot plant (3.9 MWth peak), which uses air as heat transfer fluid (HTF), has been constructed in Ait-Baha Morocco. An important characteristic of this plant is the integration of a 100 MWhth TES unit based on a packed bed of gravel as storage medium. The TES unit is designed for daily operating conditions of 10 h of charging followed by 4.5 h of discharging, at higher HTF mass flow rate, and 9.5 h of idle. The nominal charging and discharging temperatures are 570°C and 270°C respectively. A previously validated computational fluid dynamics (CFD) approach was followed to evaluate the thermo-fluid dynamics behavior of the TES unit under investigation subjected to a total of 5 pre-charging cycles, to reduce the initial transients of the system, followed by 60 consecutive cycles. The TES performance was also evaluated on the basis of the first- and the second-law of thermodynamics. According to the simulation results, despite a relatively weak thermal stratification was observed into the packed bed, the TES performance showed an increase with cycles from 52% and 63% up to stable values of 90% and 88% for the energy and the exergy efficiencies respectively.
Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery (2014)

Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow cytometry investigation revealed that the intracellular uptake of a fluorescence-labeled non-targeting siRNA (200 nM) was enhanced in the presence of [WR]5 and [WR]5-AuNPs by 2- and 3.8-fold when compared with that of siRNA alone after 24 h incubation. Comparative toxicity results showed that [WR]5 and [WR]5-AuNPs were less toxic in cells compared to other available carrier systems, such as Lipofectamine.
Roles of DNA Adenine Methylation in Regulating Bacterial Gene Expression and Virulence (2001)

DNA methylation provides a mechanism by which additional information is imparted to DNA, and such epigenetic information can alter the timing and targeting of cellular events ([47][1]). DNA methylation occurs throughout the living world, including bacteria, plants, and mammals. Until recently,