gebhart/patrepeval huggingface dataset:
Traumatic brain injury thresholds in the pre-adolescent juvenile (2012)

Traumatic brain injury (TBI) continues to be a major health epidemic, with an annual incidence in the United States in excess of 1.5 million per year, leading to 50,000 fatalities and 3.7 million people living with long-term disability from TBI. TBI is particularly devastating to the young. In countries around the globe, motor vehicle crashes are the leading cause of death for all children and traumatic brain and skull injuries are the most common serious injuries sustained by children in motor vehicle crashes. While the age-dependent tolerance of the infant and toddler have been investigated no information exists on the tolerance of pre-adolescent brain to injury. The research described herein provides critical experimental and computational TBI injury tolerance information for the pre-adolescent juvenile age group. In Chapter 2, we describe the development of a pre-adolescent TBI animal model that produces injury relevant to the human including diffuse axonal injury, subarachnoid and subdural hemorrhage, and secondary brain injury. We compare results with data from infant and toddler animals and propose an empirical scaling relationship to estimate velocity and acceleration tolerance. In Chapter 3, we develop a Finite Element Model (FEM) of pre-adolescent animal based upon a validated model from the younger animals, and determine the strain threshold for TBI in the pre-adolescent and compare it to the strain threshold of the infant. In Chapter 4, we develop an ultra high resolution finite element model with element edge length in the sub millimeter range and high geometric fidelity to both internal and external brain structures. We then use this high resolution model to investigate the effects of material heterogeneity on strain and injury prediction. Finally, in Chapter 5 we discuss the implications of our research in light of our long-term goal to support the development of human FEM brain models that can be coupled with an ATD and used to evaluate safety system design.
Analysis of manufacturing systems by the Research Queueing Package (1985)

Many aspects of manufacturing systems can be analyzed using simulation to model the system's behavior. The Research Queueing Package (RESQ) is a tool developed to construct and solve models of systems with jobs contending for service from many resources. The capabilities of RESQ are described in order to understand the model elements which are available for representing manufacturing systems. Then an analysis of several work-in-process (WIP) policies is presented using RESQ models solved by simulation. Four WIP management policies are analyzed and compared for a future assembly manufacturing line: (1) a push system, (2) a pull system, (3) a transfer line, and (4) a closed loop system.
Limit theorems for the generalized size of epidemic in a Markov model with immunization (2014)

We suggest a new Markov model for the spread of an epidemic in a closed population in which, in addition to conventional transitions interpeted as the process of infection of susceptibles and removing of infectives there exist also transitions related to immunization of susceptibles. In the well-known model with natural immunization the probability of the latter transition is proportional to the number of possible contacts of susceptibles and infectives, whereas in the model in question this probability is proportional only to the number of infectives; that is, the probability of immunization increases with increasing the number of infectives. For the model introduced we describe the class of limit laws for the generalized size of an epidemic (the sum of the number of infected and the number of immunized ones by the time the epidemic is finished) for various relations between the input parameters of the model under the assumption that the initial numbers of susceptibles and infectives tend to infinity and the parameters of the model are varying (the ‘triangular arrays’)
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis (2018)

PINK1 (PTEN-induced putative kinase 1) is a key regulator of mitochondrial homeostasis that is relatively depleted in aging lungs and in lung epithelial cells from patients with idiopathic pulmonary fibrosis (IPF), a disease linked with aging. Impaired PINK1 expression and accumulation of damaged mitochondria in lung epithelial cells from fibrotic lungs were associated with the presence of ER stress. Here, we show that ATF3 (activating transcription factor 3), a member of the integrated stress response (ISR), negatively regulates transcription of the PINK1 gene. An ATF3 binding site within the human PINK1 promoter is located in the first 150 bp upstream of the transcription start site. Induction of ER stress or overexpression of ATF3 inhibited the activity of the PINK1 promoter. Importantly, overexpression of ATF3 causes accumulation of depolarized mitochondria, increased production of mitochondrial ROS, and loss of cell viability. Furthermore, conditional deletion of ATF3 in type II lung epithelial cells protects mice from bleomycin-induced lung fibrosis. Finally, we observed that ATF3 expression increases in the lung with age and, specially, in lung epithelial cells from IPF lungs. These data provide a unique link between ATF3 and PINK1 expression suggesting that persistent stress, driven by ATF3, can dysregulate mitochondrial homeostasis by repression of PINK1 mRNA synthesis.
Mycoplasma haemolamae infection in a 4-day-old cria: support for in utero transmission by use of a polymerase chain reaction assay. (2006)

Blood smear examination in a 4-day-old alpaca revealed massive erythrocyte parasitism by Mycoplasma haemolamae. Blood collected from both the nonparasitemic dam and the cria were positive for M. haemolamae by polymerase chain reaction (PCR) analysis. These findings suggest in utero transmission of M. haemolamae in camelids, even when the dam is not parasitemic.
Communication Orale : "Structural characterization of poly(ethylene oxide-co-epichlorohydrin) membranes and relation with gas permeation properties" (2005)

International Congress on Membrane and Membrane Processes, ICOM 2005, 21-26 Août 2005, Séoul (Corée)
Dopamine and adenosine mediate substance P‐induced depression of evoked IPSCs in the rat nucleus accumbens in vitro (2003)

The major projection cells of the nucleus accumbens (NAc) are under a strong inhibitory influence from GABAergic afferents and depend on afferent excitation to produce their output. We have earlier reported that substance P (SP), a peptide which is colocalized with GABA in these neurons, depresses excitatory synaptic transmission in this nucleus (Kombian, S.B., Ananthalakshmi, K.V.V., Parvathy, S.S. & Matowe, W.C. (2003) J. Neurophysiol., 89, 728-738). In order to better understand the role of this peptide in the synaptic physiology of the NAc, it is important to determine its effects on inhibitory synaptic responses. Using whole-cell recording in rat forebrain slices, we show here that SP also depresses evoked inhibitory postsynaptic currents (IPSCs) in the NAc via intermediate neuromodulators. SP caused a partially reversible, dose-dependent decrease in evoked IPSC amplitude. This effect was present without measurable changes in the holding current, input resistance of recorded cells or decay rate (tau) of IPSCs. It was mimicked by a neurokinin-1 (NK1) receptor-selective agonist, [Sar9, Met (O2)11]-SP, and blocked by an NK1 receptor-selective antagonist, L 732 138. The SP-induced IPSC depression was prevented by SCH23390, a dopamine D1-like receptor antagonist and by 8-cyclopentyltheophylline, an adenosine A1 receptor blocker. Furthermore, the SP effect was also markedly attenuated by exogenous adenosine, dipyridamole, rolipram and barium. These data show that SP, acting on NK1 receptors, depresses inhibitory synaptic transmission indirectly by enhancing extracellular dopamine and adenosine levels. SP therefore acts in the NAc to modulate both excitatory and inhibitory afferent inputs using the same mechanism(s).
On-demand learning for a wireless campus (2004)

The current Internet and wireless networks are harsh environments for transporting high-bandwidth multimedia data. We examine the technical issues involved, and describe an end-to-end solution to support a Web-based learn-on-demand system that operates in a wireless campus environment.
ACNE VULGARIS TREATED WITH. VITAMIN A (1947)

DISCUSSION with dermatologists results in the opinion that the majority have been unable to arrive at a conclusion as to the value of treatment of acne with vitamin A or have judged it to be of little value in spite of the rather favorable report by Straumfjord. 1 Published reports have been few and inconclusive. Experimental studies by Cornbleet and his associates 2 failed to demonstrate any lack of vitamin A in the blood of patients with acne. Obermayer and Frost 3 recently said that as yet they are prepared only to state that vitamin A therapy is undoubtedly of benefit in the handling of some forms of acne vulgaris while others do not seem influenced by it. In order to arrive at an opinion, we determined to observe the effects of vitamin A given orally in a dosage of 100,000 units daily to a group of university students with
Semiconductor Bow‐Tie Nanoantenna from Coupled Colloidal Quantum Dot Molecules (2021)

Abstract Top‐down fabricated nanoantenna architectures of both metallic and dielectric materials show powerful functionalities for Raman and fluorescence enhancement with relevance to single molecule sensing while inducing directionality of chromophore emission with implications for single photon sources. We synthesize the smallest bow‐tie nanoantenna by selective tip‐to‐tip fusion of two tetrahedral colloidal quantum dots (CQDs) forming a dimer. While the tetrahedral monomers emit non‐polarized light, the bow‐tie architecture manifests nanoantenna functionality of enhanced emission polarization along the bow‐tie axis, as predicted theoretically and revealed by single‐particle spectroscopy. Theory also predicts the formation of an electric‐field hotspot at the bow‐tie epicenter. This is utilized for selective light‐induced photocatalytic metal growth at that location, unlike growth on the free tips in dark conditions, thus demonstrating bow‐tie dimer functionality as a photochemical reaction center.
A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans (2004)

The CYP27B1 promoter (-1260) C/A polymorphism appears to be associated with endocrine autoimmune diseases but the CYP27B1 intron 6 (+2838) C/T polymorphism appears to be associated only with Hashimoto's thyroiditis. These results imply a regulatory difference of the CYP27B1 hydroxylase to predispose to endocrine autoimmunity.
Improved router & server OPEX, acoustics and leakage power through advancements in ASIC / CPU design (2016)

Increasing thermal demands for high-end server CPUs and Router/Switch ASICs require increased performance for the air-cooled system thermal design in order to meet increasing industry needs. Improving the CPU/ASIC package thermal performance is one of the critical areas for improving multiple system level thermal design issues. This includes (a) increasing the maximum CPU/ASIC power; (b) reducing the leakage power dissipation and associated OPEX through attaining a lower junction temperature; (c) lowering OPEX by being able to reduce air flow requirements and associated power required for the air movers; and (d) reducing the server OSHA sound pressure level, along with reducing the router/switch NEBS acoustic sound power level due to realizing a lower air flow requirement.
Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism (2021)

Abstract Background Multiple studies of tissue and cell samples from patients and pre-clinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic feature of this disease. Peroxisomes interact with mitochondria physically and functionally, and congenital peroxisome biogenesis disorders can cause various phenotypes, including mitochondrial defects, metabolic abnormalities and renal cysts. We hypothesized that a peroxisomal defect might contribute to the metabolic and mitochondrial impairments observed in autosomal dominant polycystic kidney disease. Methods Using control and Pkd1 -/- kidney epithelial cells, we investigated peroxisome abundance, biogenesis and morphology by immunoblotting, immunofluorescent and live cell imaging of peroxisome-related proteins and assayed peroxisomal specific β-oxidation. We further analyzed fatty acid composition by mass spectrometry in kidneys of Pkd1 fl/fl ; Ksp-Cre mice. We also evaluated peroxisome lipid metabolism in published metabolomics datasets of Pkd1 mutant cells and kidneys. Lastly, we investigated if the C-terminus or full-length polycystin-1 co-localize with peroxisome markers by imaging studies. Results Peroxisome abundance, morphology and peroxisome-related protein expression in Pkd1 -/- cells were normal, suggesting preserved peroxisome biogenesis. Peroxisomal β-oxidation was not impaired in Pkd1 -/- cells, and there was no obvious accumulation of very long chain fatty acids in kidneys of mutant mice. Re-analysis of published datasets provide little evidence of peroxisomal abnormalities in independent sets of Pkd1 mutant cells and cystic kidneys, while providing further evidence of mitochondrial fatty acid oxidation defects. Imaging studies with either full length polycystin-1 or its C-terminus, a fragment previously shown to go to the mitochondria, showed minimal co-localization with peroxisome markers. Conclusions Our studies showed that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent fatty acid metabolism. Key points - While mitochondrial abnormalities and fatty acid oxidation impairment have been reported in ADPKD, no studies have investigated if peroxisome dysfunction contributes to these defects. - We investigated peroxisome morphology, biogenesis and function in cell and animal models of ADPKD and investigated whether polycystin-1 co-localized with peroxisome proteins. - Our studies show that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent fatty acid metabolism.
Managing large graphs on multi-cores with graph awareness (2012)

Grace is a graph-aware, in-memory, transactional graph management system, specifically built for real-time queries and fast iterative computations. It is designed to run on large multi-cores, taking advantage of the inherent parallelism to improve its performance. Grace contains a number of graph-specific and multi-core-specific optimizations including graph partitioning, careful in-memory vertex ordering, updates batching, and load-balancing. It supports queries, searches, iterative computations, and transactional updates. Grace scales to large graphs (e.g., a Hotmail graph with 320 million vertices) and performs up to two orders of magnitude faster than commercial key-value stores and graph databases.
Cost effective glassy carbon brake pad solution for automotive systems (2012)

In this work, thermal degradation of commercial polymer mixtures was evaluated as a promising approach to the production of ceramic brake components. Currently, there is a wide interest for the production of cost effective ceramic pads, and carbon based materials are good candidates both in monolithic form and as porous networks to be reinfiltrated with a convenient polymer. The process parameters for obtaining porous glassy carbon, starting from mixtures of commercial polymers, have been evaluated in this work with the goal of producing samples with optimised mechanical properties. A preliminary study of the pyrolysis process has been carried out using thermogravimetric analysis coupled with mass spectrometry Raman spectroscopy and field emission scanning electron microscopy coupled with energy dispersive X-ray in order to define the feasibility of the method and to point out the critical issues. Mechanical tests have been performed in order to understand the relation between the carbonisation process and the mechanical properties.
A Unified Dynamic Characterization Framework for Microgrid Systems (2011)

Abstract A systematic, automatable, unified methodology is presented for the modeling of non-linear large-signal dynamics and eigenvalue analysis of microgrid systems. Unlike nodal-based simulators and typical state-variable methods that require Kirchhoff's current law analysis, a state-space model is systematically derived from the netlist of the equivalent qd microgrid circuit model. The model may be used to conduct time-domain simulations and analyze system response to large transients. Additionally, system eigenvalues may be analyzed with respect to inverter control gains and system parameters to assess small-signal stability and sensitivity. The dynamic model is verified against existing experimental results, and small-signal stability results are presented.
Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies (2019)

The cyclooxygenase-2 (COX-2) enzyme is considered to be an important target for developing novel anti-inflammatory agents. Selective COX-2 inhibitors offer the advantage of lower adverse effects that are commonly associated with non-selective COX inhibitors. In this work, a novel series of methyl 3-(substituted benzoyl)-7-substituted-2-phenylindolizine-1-carboxylates was synthesized and evaluated for COX-2 inhibitory activity. Compound 4e was identified as the most active compound of the series with an IC50 of 6.71 μM, which is comparable to the IC50 of indomethacin, a marketed non-steroidal anti-inflammatory drug (NSAID). Molecular modeling and crystallographic studies were conducted to further characterize the compounds and gain better understanding of the binding interactions between the compounds and the residues at the active site of the COX-2 enzyme. The pharmacokinetic properties and potential toxic effects were predicted for all the synthesized compounds, which indicated good drug-like properties. Thus, these synthesized compounds can be considered as potential lead compounds for developing effective anti-inflammatory therapeutic agents.
Reductive coupling of carbonyl compounds to olefins by tungsten hexachloride-lithium aluminum hydride and some tungsten and molybdenum carbonyls (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive coupling of carbonyl compounds to olefins by tungsten hexachloride-lithium aluminum hydride and some tungsten and molybdenum carbonylsYuzo Fujiwara, Ryuichi Ishikawa, Fumitaka Akiyama, and Shiichiro TeranishiCite this: J. Org. Chem. 1978, 43, 12, 2477–2480Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/jo00406a040https://doi.org/10.1021/jo00406a040research-articleACS PublicationsRequest reuse permissionsArticle Views513Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Case of Gastric Foreign Body (Dental Prosthesis with Sharp Clasp) Treated with Endoscopic Removal (2009)

症例は46歳男性。餅を食べた際に義歯を誤飲したが，近医にて経過観察された。2日後嘔気を認め，上部消化管内視鏡検査施行し，胃幽門輪にクラスプが刺入した義歯を認めた。異物鉗子にてクラスプを把持し，刺入方向と反対周りの水平方向に回転する事で義歯を胃内に摘出できた。その後EEMRチューブを用いて食道損傷なく回収した。胃幽門輪に刺入した有鉤義歯の内視鏡的摘出には，水平方向に回転することが有用と思われた。
Determination of nickel, copper, selenium, cadmium, thallium, and lead in coal gasification products by isotope dilution spark source mass spectrometry (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of nickel, copper, selenium, cadmium, thallium, and lead in coal gasification products by isotope dilution spark source mass spectrometryD. W. Koppenaal, R. G. Lett, F. R. Brown, and S. E. ManahanCite this: Anal. Chem. 1980, 52, 1, 44–49Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ac50051a012https://doi.org/10.1021/ac50051a012research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acknowledgment of Reviewers (2016)

On behalf of the editors of mBio, I gratefully acknowledge the following individuals, who served as reviewers for the journal in 2016. Their time and effort in reviewing articles have been essential in ensuring the high quality of our publications, and their help is greatly appreciated.
Topic2Vec: Learning Distributed Representations of Topics (2015)

Latent Dirichlet Allocation (LDA) mining thematic structure of documents plays an important role in nature language processing and machine learning areas. However, the probability distribution from LDA only describes the statistical relationship of occurrences in the corpus and usually in practice, probability is not the best choice for feature representations. Recently, embedding methods have been proposed to represent words and documents by learning essential concepts and representations, such as Word2Vec and Doc2Vec. The embedded representations have shown more effectiveness than LDA-style representations in many tasks. In this paper, we propose the Topic2Vec approach which can learn topic representations in the same semantic vector space with words, as an alternative to probability. The experimental results show that Topic2Vec achieves interesting and meaningful results.