gebhart/patrepeval huggingface dataset:
Relating Desorption and Biodegradation of Phenanthrene to SOM Structure Characterized by Quantitative Pyrolysis GC-MS (2005)

A set of four soils was extensively studied for composition, sorption/desorption, and biodegradation to investigate linkages among these three inter-related factors. Composition of soil organic matter (SOM) was quantitatively characterized using pyrolysis GC-MS; although CO2 dominated the total ion chromatogram for all soils, each soil produced a distinctively different pyrogram and 1.4-4.8% of the soil carbon was quantified as one of 205 pyrolysis marker compounds using external standards. Amorphous and free iron and aluminum contents were determined as potential indicators of the reactivity of the mineral phase, which may influence the configuration and accessibility of SOM domains within soil. We observed a statistically significant positive correlation between two-site model fast fraction f values derived from mineralization and desorption rate studies, which suggests that desorption limits biodegradation. However, no statistically significant correlation was observed between two-site model fast and slow rate constants (k(f), k(s)) for the two processes. No evidently strong correlations were found between functional parameters (organic carbon normalized distribution coefficient Koc, hyeteresis index HI, and two-site model parameters f, k(f), and k(S) for both desorption and biodegradation and maximum rate and extent of biodegradation) and SOM structural descriptors (pyrolysis results). Lack of strong correlations may suggest (i) that multiple SOM structures are collectively responsible for desorption resistance or (ii) that the pyrolysis GC-MS method used in this study was unable to identify relevant structures. In contrast, amorphous and free iron and aluminum contents showed statistically significant correlations with K(OC) and HI values, indicating the potential importance of underlying mineral phases in determining desorption and biodegradation rates.
Immunocytochemical localization of plasminogen activators in carcinomas in the cervix and vulva. (1994)

The presence of plasminogen activators (PA) in a variety of solid tumours appears to correlate, in a number of instances, with enhanced invasive and/or metastatic ability. Urokinase and tissue-type plasminogen activators (u-PA and t-PA) in normal and neoplastic tissues of cervix and of vulva were immunohistochemically identified by means of polycyclonal antibodies. In addition, frozen sections were analysed for u-PA and t-PA activity by in-situ zymography technique. Data collected in our study showed that in invasive cancer u-PA increased more in malignant cells as compared to normal cells in both the inactive and active enzymatic forms. The t-PA distribution pattern was related to angiogenesis while it did not relate to the degree of tumor differentiation. A synergic interaction between proteolytic tumoral activity and proteolytic inflammatory action could be hypothesized.
Evaluation of the Anti-oxidative Effect (in vitro) of Tea Polyphenols (2003)

Forty-three polyphenols from tea leaves were evaluated for their anti-oxidative effect against lipid peroxidation by the ferric thiocyanate method in vitro. Among these, 1,4,6-tri-O-galloyl-beta-D-glucose (hydrolyzable tannin) showed the highest anti-oxidative activity against lipid peroxidation, even stronger than that of 3-tert.-butyl-4-hydroxyanisole (BHA). The assay demonstrates that tea polyphenols, except for desgalloylated dimeric proanthocyanidins that possess a catechin structure in the upper unit and desgalloylated flavan-3-ols, and excepting theaflavin 3,3'-di-O-gallate, had more anti-oxidative activity than that of alpha-tocopherol. The chemical structure-activity relationship shows that the anti-oxidative action advanced with the condensation of two molecules of flavan-3-ols as well as with 3-O-acylation in the flavan skeleton such as that by galloyl, (3'-O-methyl)-galloyl, and p-coumaroyl groups.
Experimental comparison of 40 Gb/s RZ-, CSRZ-, and NRZ-DPSK modulation formats over non slope-matched fibers (2005)

Various DPSK modulation formats were experimentally compared at 40 Gb/s using non slope-matched fiber spans. All formats benefited from dispersion slope compensation. For co-polarized channels on 100 GHz spacing CSRZ-DPSK worked best. (2 pages)
Minor difference in postprandial responses of men between starch and sugar when replacing fat in a normal meal (1990)

Healthy male volunteers consumed hot lunches consisting of cooked white rice, fried chicken fillet, raisins, bigarreaus (sweet cherries) and curry sauce with carbohydrate: fat ratios of either 0.77 or 2.04, and polysaccharide: (mono + di)saccharide ratios (P:MD) varying between 5.3 and 0.95. Before and at various time intervals after the start of the meal, blood samples were analysed for glucose, insulin, triacylglycerol (TG), free glycerol (FG), free fatty acids (FFA) and cholesterol. Elevated postprandial glucose and insulin peaks were induced by the meals containing a larger amount of carbohydrate. The type of carbohydrate in the meal appeared to have little or no effect on the peak maximum. A small second glucose peak was seen at 2 h after the meals with P: MD greater than 3.1. The TG concentration in the blood showed a similar and rapid rise. After the meal containing the largest amount of simple sugars, the TG curve levelled off 1 h after the start of the meal and then remained at a nearly constant level (1.5 mM). In contrast, a larger amount of complex carbohydrates induced a TG concentration which rapidly rose to a maximum of 1.75 mM, and subsequently decreased slowly to somewhat below that of the simple sugar-rich meal at 4 h. The postprandial curves after the fat-rich meals showed a continuous rise of TG up to a maximum of about 2 mM at 2 h, and a subsequent slow decrease. FG and FFA all showed a rapid drop immediately after the start of the consumption of the meals, followed by a rebound at 1 h. The postprandial curves of total cholesterol, as well as the areas below the curve of both total cholesterol and free, unesterified cholesterol were lower after the carbohydrate-rich meals than after the fat-rich meals. This is attributed to the larger amount of cholesterol in the fat-rich meals.
The first co-axial flow pump for human use: the Hemopump (1991)

Many people ask me how I thought up this idea. It came about when I traveled to Egypt to work in a village just outside Cairo with the Bedouin people to evolve a plan to solve the problem of contaminated drinking water. During this visit I learned a piece of information that helped me design the Hemopump. Based on the principle of a submersible pump, we pumped water from a deep well. When applied to the problem of pumping blood, I thought, why not create a heart pump that pumps from inside the bloodstream?
Characterization of electroless copper as a seed layer for sub-0.1 /spl mu/m interconnects (2001)

Complete gapfill of 0.1 /spl mu/m features with electroless Cu seed layers and electroplated Cu was demonstrated. Electrical tests on test structures indicated similar line and via chain resistance, yield and line-to-line leakage current on wafers with electroless Cu seed and PVD Cu seed layers filled with electroplated Cu.
Reduction of Dynamic Multipole Content in Insertion Devices Using Flat Wires (2018)

Multipole errors of an insertion device are generally corrected based on measurements and analysis of the magnetic field integrals. Multipole components in a strong and narrow non-uniform field of an insertion device appear as dynamic multipoles. Flat wires were installed and commissioned to determine if the dynamic multipoles can be eliminated in an APPLE-II type undulator. In this work, we will discuss and compare the reduction of the dynamic multipole content and it's beam dynamics effects with the flat wire through an analysis of field calculations and beam-based measurements in the storage ring.
Brain Metastases and Elevated α-Fetoprotein Level in a Patient With Esophageal Carcinoma (1986)

Carcinoma of the esophagus rarely metastasizes to the brain. We have reported a case of esophageal cancer in a patient with early central nervous system metastasis and an exceptionally high level of serum alpha-fetoprotein, a finding not previously described with this neoplasm.
Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity. (1999)

The tertiary amine N-oxide (nitracrine-N-oxide, 1b) of the 1-nitroacridine nitracrine is a bis-bioreductive agent showing very high hypoxic selectivity (approximately 1000-fold) against tumour cells in culture, but only modest activity against the hypoxic subfraction of tumours in vivo. Because the hypoxic selectivity of 1b was considered to depend significantly on the rate of enzyme-mediated reduction of the N-oxide group, this paper reports the preparation and evaluation of a series of analogues in which the environment of this group was modified. Three analogues contained more weakly basic N-oxides, while two others had varying degrees of steric bulk around the N-oxide. In all but one case (an aromatic N-oxide), the N-oxides were much less cytotoxic (10- to 300-fold) than the corresponding tertiary amines towards AA8 Chinese hamster cells under aerobic conditions. Both the N-oxides and the corresponding amines were more cytotoxic to an ERCC-1 mutant defective in nucleotide excision repair, indicating that DNA alkylation was the cytotoxic event. However, there was no apparent correlation of these parameters with structure. All of the aliphatic N-oxides, with the exception of the aromatic N-oxide example, showed substantial (70- to 800-fold) hypoxic selectivity against AA8 cells in a clonogenic assay. While the weakly basic derivatives were the least selective, there was no apparent relationship between hypoxic selectivity and the steric environment of the N-oxide. Selectivity for hypoxic cells in culture is shown to depend on the hypoxic selectivity of the corresponding tertiary amine (reflecting O2-inhibitable reduction of the 1-nitro group) and the differential in aerobic toxicity between amine and N-oxide (a measure of the potential toxicity increase achievable by reducing the N-oxide). Four analogues whose structures fairly represented the range of steric and electronic modifications of the N-oxide site were evaluated against the hypoxic subfraction of cells in KHT tumours in vivo, but were inactive. These results suggest that either such modifications do not exert significant effects on N-oxide reduction, or that the rate of such reduction is not a factor limiting the in vivo activity of the parent analogue 1b.
Bridge damage detection using spatiotemporal patterns extracted from dense sensor network (2016)

The alarmingly degrading state of transportation infrastructures combined with their key societal and economic importance calls for automatic condition assessment methods to facilitate smart management of maintenance and repairs. With the advent of ubiquitous sensing and communication capabilities, scalable data-driven approaches is of great interest, as it can utilize large volume of streaming data without requiring detailed physical models that can be inaccurate and computationally expensive to run. Properly designed, a data-driven methodology could enable fast and automatic evaluation of infrastructures, discovery of causal dependencies among various sub-system dynamic responses, and decision making with uncertainties and lack of labeled data. In this work, a spatiotemporal pattern network (STPN) strategy built on symbolic dynamic filtering (SDF) is proposed to explore spatiotemporal behaviors in a bridge network. Data from strain gauges installed on two bridges are generated using finite element simulation for three types of sensor networks from a density perspective (dense, nominal, sparse). Causal relationships among spatially distributed strain data streams are extracted and analyzed for vehicle identification and detection, and for localization of structural degradation in bridges. Multiple case studies show significant capabilities of the proposed approach in: (i) capturing spatiotemporal features to discover causality between bridges (geographically close), (ii) robustness to noise in data for feature extraction, (iii) detecting and localizing damage via comparison of bridge responses to similar vehicle loads, and (iv) implementing real-time health monitoring and decision making work flow for bridge networks. Also, the results demonstrate increased sensitivity in detecting damages and higher reliability in quantifying the damage level with increase in sensor network density.
SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation (2013)

Despite the importance of the immune adaptor SLP-76 in T-cell immunity, it has been unclear whether SLP-76 directly self-associates to form higher order oligomers for T-cell activation. In this study, we show that SLP-76 self-associates in response to T-cell receptor ligation as mediated by the N-terminal sterile α motif (SAM) domain. SLP-76 co-precipitated alternately tagged SLP-76 in response to anti-CD3 ligation. Dynamic light scattering and fluorescent microscale thermophoresis of the isolated SAM domain (residues 1-78) revealed evidence of dimers and tetramers. Consistently, deletion of the SAM region eliminated SLP-76 co-precipitation of itself, concurrent with a loss of microcluster formation, nuclear factor of activated T-cells (NFAT) transcription, and interleukin-2 production in Jurkat or primary T-cells. Furthermore, the H5 α helix within the SAM domain contributed to self-association. Retention of H5 in the absence of H1-4 sufficed to support SLP-76 self-association with smaller microclusters that nevertheless enhanced anti-CD3-driven AP1/NFAT transcription and IL-2 production. By contrast, deletion of the H5 α helix impaired self-association and anti-CD3 induced AP1/NFAT transcription. Our data identified for the first time a role for the SAM domain in mediating SLP-76 self-association for T-cell function.
Cascade Molecules: 15.1Synthesis of Tris(3-substituted) Tripropylnitromethanes (1991)

Starting from 4-(3-hydroxypropyl)-4-nitro-1,7-heptanediol, a series of polyfunctional nitromethane derivatives, 1,3′,7-trisubstituted 4-nitro-4-propylheptanes, has been prepared and spectroscopically correlated; these derivatives validate methodologies for surface derivativization of specifically sized cascade polymers.
Modelling the evolution of domains in nanoelements using finite elements (1999)

Investigation into the magnetic behavior of permalloy has become more advanced due to improvements in numerical micromagnetic methods on the theoretical side and high accuracy electron-beam lithography methods experimentally. If the material is discretised into a nano-element structure, micromagnetic calculations may be carried out in order to investigate the material behavior.
Markers-based space decomposition algorithm: a new algorithm for multi-fields packet classification (2006)

Packet classification is a central function in several network applications such as firewalls and QoS-enhanced routers. Several schemes were proposed for fast packet classification, but few ones support incremental updates. In this paper, we present a new multi-fields packet classification algorithm and show its advantages compared to previous proposed algorithms. We present performance measurements using a free benchmark developed at Washington University. We show how this algorithm performs improved search times without any limitation in terms of incremental updates.
Surgical Electrotechnology: Quo Vadis? (1984)

The development of the modern electrosurgical generator and its accessories is outlined. The use of the electrosurgical scalpel is compared to other thermal knives: the plasma scalpel and the laser. The evolution of the dispersive electrode is summarized. Some of the innovations in endoscopic electrosurgery and the associated problems are discussed, along with a summary of some current research in hazard detection and waveform generating techniques and its impact on the next generation of electrosurgical generators.
CAGE16-7 Cruise Report: Deployment of observatories and water column survey in the Barents Sea and offshore Svalbard (2023)

The cruise was conducted from October 16th to 25th 2016 as part of the Centre of Excellence for Arctic Gas Hydrate, Environment and Climate (CAGE) at UiT – The Arctic University of Norway. The main goal of the cruise was to deploy two observatories in the pingo-crater area (“Yin Yang”) in the Barents Sea, and offshore Svalbard at the same location where OS2 was deployed in June 2015 and recovered in May 2016. The exact targeted location was determined according to multibeam analysis in order to deploy in the vicinity of bubble streams. The previously K-Landers called OS1 (black) and OS2 (grey) are now called K-Lander 1 and K-Lander 2. They contain a CH4 sensor, a CO2 sensor, a CTD, a pH meter, and a hydrophone. K-Lander 1 contains in addition a DVS (Doppler volume sampler) as the broken ADCP did not arrive on time for the deployment. K-Lander 2 contains in addition an ADCP, a transmissometer (for turbidity measurement) and an M3 (Multibeam echosounder). The present cruise also aimed at investigating an area of extensive flares western Svalbard, particularly the shallow shelf and shelf edge. The addressed scientific topics include quantification of methane concentration in the water column, temperature and salinity (via CTD casts), echosounder and multibeam signals and current (amplitude and direction) The cruise may be known as: CAGE16_7
Classification Systems for Human Immunodeficiency Virus (HIV) Infection (1988)

Letters and Corrections1 January 1988Classification Systems for Human Immunodeficiency Virus (HIV) InfectionJOSEPH D. DIAZ, M.D., ALBERTO BERMAN, M.D., RICHARD F. LOCKEY, M.D., LUIS R. ESPINOZA, M.D.JOSEPH D. DIAZ, M.D.Search for more papers by this author, ALBERTO BERMAN, M.D.Search for more papers by this author, RICHARD F. LOCKEY, M.D.Search for more papers by this author, LUIS R. ESPINOZA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-155_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Several classification systems based on clinical and immunologic profiles have been proposed for patients infected with the human immunodeficiency virus (HIV) (1, 2). A single classification system is preferable. Such a classification should increase awareness of the spectrum of HIV infection, provide a uniform nomenclature for clinical staging, facilitate understanding of the natural history of HIV disease, aid in disease surveillance and reporting, and help in evaluation of response to HIV therapy. This system should also provide a basis for standardizing clinical and epidemiologic studies, analyzing morbidity and mortality associated with HIV, and developing criteria for disability...References1. . Classification system for human T-lymphotropic virus type III/lymphadenopathy associated virus infections. MMWR. 1986;35:334-9. MedlineGoogle Scholar2. REDFIELDWRIGHTTRAMONT RDE. The Walter Reed staging classification for HTLV-III/LAV infection. N Engl J Med. 1986;314:131-2. CrossrefMedlineGoogle Scholar3. SOLOMONCURRAN SJ. Public health applications of a classification system for human immunodeficiency virus infection. Ann Intern Med. 1987;106:319-21. LinkGoogle Scholar4. . Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. JAMA. 1987;258:1143-54. CrossrefMedlineGoogle Scholar5. KLEINHARRISSMALLMOLLLESSERFRIEDLAND RCCBMG. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med. 1984;311:354-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH D. DIAZ, M.D.; ALBERTO BERMAN, M.D.; RICHARD F. LOCKEY, M.D.; LUIS R. ESPINOZA, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Staging and Monitoring by Primary Care Providers of Patients with Human Immunodeficiency Virus Infections 1 January 1988Volume 108, Issue 1Page: 155-156KeywordsClinical immunologyDisabilitiesDisease surveillanceHIVHIV epidemiologyHIV infectionsHIV-1MorbidityMortalityNatural history of disease ePublished: 1 December 2008 Issue Published: 1 January 1988 PDF downloadLoading ...
pH-Induced dissociation of bovine casein micelles. I. Analysis of liberated caseins (1988)

Summary The dissociation of caseins of different types from casein micelles in milk, acidified to different pH values in the range 4·9–6·7, and at temperatures of 4, 20 and 30 °C, has been studied. In contrast to a number of previous findings, it was shown that caseins of all types were dissociated from the micelles, although in all cases β-casein was in highest concentration. The amounts and proportions of all of the caseins were found to be pH- and temperature-dependent, especially the former. Studies of the proportions of the different caseins liberated suggested that, at a defined temperature, the proportions of κ;- and α s2 -caseins were independent of pH, while the proportions of β- and α sl -caseins were variable, changes in one being compensated by changes in the other. The manner in which the proportions of the α sl -casein and β-caseins changes with pH was found to be temperature-dependent.
Preclinical Three-Dimensional Vibrational Shear Wave Elastography for Mapping of Tumour Biomechanical Properties In Vivo (2022)

Preclinical investigation of the biomechanical properties of tissues and their treatment-induced changes are essential to support drug-discovery, clinical translation of biomarkers of treatment response, and studies of mechanobiology. Here we describe the first use of preclinical 3D elastography to map the shear wave speed (cs), which is related to tissue stiffness, in vivo and demonstrate the ability of our novel 3D vibrational shear wave elastography (3D-VSWE) system to detect tumour response to a therapeutic challenge. We investigate the use of one or two vibrational sources at vibrational frequencies of 700, 1000 and 1200 Hz. The within-subject coefficients of variation of our system were found to be excellent for 700 and 1000 Hz and 5.4 and 6.2%, respectively. The relative change in cs measured with our 3D-VSWE upon treatment with an anti-vascular therapy ZD6126 in two tumour xenografts reflected changes in tumour necrosis. U-87 MG drug vs vehicle: Δcs = −24.7 ± 2.5 % vs 7.5 ± 7.1%, (p = 0.002) and MDA-MB-231 drug vs vehicle: Δcs = −12.3 ± 2.7 % vs 4.5 ± 4.7%, (p = 0.02). Our system enables rapid (<5 min were required for a scan length of 15 mm and three vibrational frequencies) 3D mapping of quantitative tumour viscoelastic properties in vivo, allowing exploration of regional heterogeneity within tumours and speedy recovery of animals from anaesthesia so that longitudinal studies (e.g., during tumour growth or following treatment) may be conducted frequently.
Self-operated endovaginal telemonitoring versus traditional monitoring of ovarian stimulation in assisted reproduction: an RCT (2014)

EC/2011/669 (Ghent University Hospital), B670201112232 (Belgian registration) and NCT01781143 (clinical trials number).
Draft Genome Sequences of Two Paenibacillus Isolates from Goose and Chicken Gastrointestinal Material (2020)

Here, we present the draft genome sequences of two <i>Paenibacillus</i> strains, An7 and USDA918EY, isolated from goose feces (Bend, OR, USA) and chicken ceca (Pomona, CA, USA), respectively. These data may assist with analyses of microorganisms associated with free-ranging and commercial avian species.