gebhart/patrepeval huggingface dataset:
High-order Harmonic Generation in Femtosecond Laser Micromachined Devices for Ultrafast X-ray Spectroscopy (2020)

We demonstrate efficient high-order harmonic generation in fused-silica chips fabricated by femtosecond laser micromachining. This work provides a route toward the miniaturization of HHG beamlines and the implementation of X-ray spectroscopy with attosecond temporal resolution.
2‐Undecanone, a constituent of the glandular trichomes of Lycopersicon hirsutum f. glabratum: Effects on Heliothis zea and Manduca sexta growth and survival (1987)

Abstract The effects of 2‐undecanone, a compound found in the glandular trichomes of the wild tomato, Lycopersicon hirsutum f. glabratum C. H. Mull, PI 134417, on the larvae of Heliothis zea (Boddie) and Manduca sexta (L.) were studied by rearing the larvae on artificial diets containing this chemical. 2‐Undecanone increased larval mortality of H. zea in the first 48 h when combined with 2‐tridecanone, but not alone, and caused deformity and mortality of H. zea pupae both alone and in combination with 2‐tridecanone. 2‐Undecanone had no effect on M. sexta larvae or pupae. Potential implications of these findings for insect pest management are discussed. RÉSUMÉ 2‐Undécanone, un element dans les extrémités des poils glandulaires de Lycopersicon hirsutum f. glabratum: Effets sur la croissance et la survivance de Heliothis zea et Manduca sexta. Le 2‐undécanone est une methyle cétone qui se trouve avec le 2‐tridécanone dans les extrémités des poils glandulaires des feuilles de la tomate sauvage: Lycopersicon hirsutum f. glabratum C. H. Mull, PI 134417. Notre étude entreprendait à rechercher le rîle du 2‐undécanone dans la resistance de cette plante à Heliothis zea et Manduca sexta. Les produits chimiques synthétiques s'étaient incorporés en diète artificièlle sur laquelle les insectes ont élevés. Le 2‐undécanone a causé peu de mortalité des larves de H. zea sauf quand il soit combiné avec le 2‐tridécanone, dans quel cas on trouve, dans les premiers 48 heures, une augmentation de mortalité, en comparaison au 2‐tridécanone seul. Aussi le 2‐undécanone a causé les difformités des nymphes de H. zea et la mortalité dans I'étage de nymphe, toutes les deux seul et en combinaison avec le 2‐tridécanone. En contrast, le 2‐undécanone n'a pas produit un effet sur les larves ou nymphes de M. sexta. L'élevage sélective des lignes de tomates de niveau plus élevé de 2‐undécanone pourrait utile pour la lutte contre le H. zea , En combinaison avec des niveaux élevés du 2‐tridécanone, c'est possible de reduire les populations nuisibles des larves. II peut aussi réduire le nombre des lépidoptères adultes produit dans la récolte de tomate. Toutefois, il ne serait pas probablement de valeur dans la lutte contre le M. sexta.
Wound image analysis system for diabetics (2013)

Diabetic foot ulcers represent a significant health issue, and daily wound care is necessary for wound healing to occur. The goal of this research is to create a smart phone based wound image analysis system for people with diabetes to track the healing process of chronic ulcers and wounds. This system has been implemented on an Android smart phone in collaboration with a PC (or embedded PC). The wound image is captured by the smart phone camera and transmitted to the PC via Wi-Fi for image processing. The PC converts the JPEG image to bitmap format, then performs boundary segmentation on the wound in the image. The segmentation is done with a particular implementation of the level set algorithm, the <i>distance regularized level set evolution</i> (DRLSE) method, which eliminates the need for re-initialization of level set function. Next, an assessment of the wound healing is performed with color segmentation within the boundaries of the wound image, by applying the K-Mean color clustering algorithm based on the red-yellow-black (RYB) evaluation model. Finally, the results are re-formatted to JPEG, transmitted back to the smart phone and displayed. To accelerate the wound image segmentation, we have implemented the DRLSE method on the GPU and CPU cooperative hardware platform in data-parallel mode, which has greatly improved the computational efficiency. Processing wound images acquired from UMASS Medical Center has demonstrated that the wound image analysis system provides accurate wounds area determination and color segmentation. For all wound images of size around 640 x 480, with complicated wound boundaries, the wound analysis consumed max 3s, which is 5 times faster than the same algorithm running on the CPU alone.
Expression of de novo Designed alpha-Helical Bundles. (1996)

The successful design of proteins requires careful consideration of the multiplicity of forces that stabilize their three-dimensional structures including hydrophobic interactions, hydrogen-bonding, electrostatics and weakly polar interactions. Early attempts to design proteins relied too heavily on hydrophobic interactions to provide stability, resulting in structures with dynamic properties. Addition of more specific interactions to these initial designs gives rise to proteins with more native-like properties. This manuscript describes the design of native-like three- and four-helix bundles, and their cloning and expression of these proteins.
Cloning and Sequence Analysis of Bmtdh Gene in Bombyx mori (2007)

We cloned and sequenced the cDNA(1 310 bp,accession No.ABA43639.1) of L-threonine 3-dehydrogenase(TDH) in Bombyx mori.It contains a 227 bp 5′ untranslated region(5′-UTR),locates on the genome as a single copy and encodes a 342-residue protein.The region between Ile29 and Val322 is a complete episomerase domain.The expression profile and EST analysis indicated the mRNA transcription level of Bmtdh gene was higher in silk gland and ovary at the 3rd day of 5th instar than that of other tissues.RT-PCR experiments of 11 different development periods showed that high transcription level of Bmtdh gene appeared at the 4th molting stage,1st day and 3rd day of 5th instar,but it was not detected in G2 embryo period and at the 2nd day of 1st instar.This results suggested the Bmtdh gene maybe involved in the process of silk protein synthesis.
Reduced-complexity entropy coding of transform coefficient levels using truncated golomb-rice codes in video compression (2011)

In hybrid video coding, the difference between the intra or inter prediction signal and the original signal is transmitted using block-based transform coding. The state-of-the-art in coding the quantized transform coefficients is the approach specified in H.264/AVC for context-adaptive binary arithmetic coding. It has, however, been shown that the number of binary symbols that have to be arithmetically coded for the transform coefficients can become very large, making the concept less attractive for high rate applications. To overcome this issue, we propose a combination of simple variable-length codes and context-adaptive binary coding, which yields the same coding efficiency as the H.264/AVC transform coefficient coding at a lower complexity level and which has been adopted into the HEVC test model (HM).
5. Vorlesung (18.11.2020): Erderwärmung ... (2020)

… ist ein Sache für Profis!? Ein solcher Spruch aus Politikermund kann für&#13;\nunsere Veranstaltungsreihe »Samstagsvorlesung« nur als Auftrag verstanden&#13;\nwerden. Wir werden deshalb eine gute Stunde eines Samstagsvormittags darauf&#13;\nverwenden, dem Treibhaus-Effekt der Atmosphäre nachzuspüren. In den&#13;\nfast 200 Jahren seit seiner Entdeckung ist viel an interessanten Geschichten,&#13;\nExperimenten und theoretischen Modellen zusammengekommen. Einiges&#13;\ndavon ist gar nicht schwer zu verstehen. Das gilt sogar für ein physikalisches&#13;\nModell, aus dem sich der Zusammenhang zwischen Treibhauseffekt und Erdtemperatur&#13;\nannähernd quantitativ ergibt – damit jeder mitreden und Fakten&#13;\nvon alternativen Fakten unterscheiden kann.
Children with unilateral cochlear nerve canal stenosis have bilateral cochleovestibular anomalies (2018)

3b Laryngoscope, 129:2403-2408, 2019.
Using microenvironments to identify allosteric binding sites (2012)

Protein amino acid residues can be classified by their chemical properties and data mining can be used to make predictions about their structure and function. However, the properties of the surrounding residues contribute to the overall chemical context. This paper defines microenvironments as the spherical volume around a point in space and uses these volumes to determine average properties of the encompassed residues. The approach to index generation rapidly constructs microenvironment data. The averaged chemical properties are then employed in allosteric site prediction using support vector machines and neural networks. The results show that index generation performs best when microenvironment radius matches the granularity of the index and that microenvironments improve the classification accuracy.
Field emitter array image sensor with HARP target (2002)

A new type of flat image sensor, consisting of an FEA (field emitter array) and a high sensitive photoconductive film, is proposed. An experimental sensor, which has 128 /spl times/ 96 pixels, was fabricated and tested. Experimental results showed that the sensor could take two-dimensional images, demonstrating its potential as a next-generation image sensor.
Deactivation of Methylrhenium Trioxide−Peroxide Catalysts by Diverse and Competing Pathways (1996)

The peroxides from methylrhenium trioxide (MTO) and hydrogen peroxide, CH3ReO2(η2-O2), A, and CH3Re(O)(η2-O2)2(H2O), B, have been fully characterized in both organic and aqueous media by spectroscopic means (NMR and UV−vis). In aqueous solution, the equilibrium constants for their formation are K1 = 16.1 ± 0.2 L mol-1 and K2 = 132 ± 2 L mol-1 at pH 0, μ = 2.0 M, and 25 °C. In the presence of hydrogen peroxide the catalyst decomposes to methanol and perrhenate ions with a rate that is dependent on [H2O2] and [H3O+]. The complex peroxide and pH dependences could be explained by one of two possible pathways: attack of either hydroxide on A or HO2- on MTO. The respective second-order rate constants for these reactions which were deduced from comprehensive kinetic treatments are kA = (6.2 ± 0.3) × 109 and kMTO = (4.1 ± 0.2) × 108 L mol-1 s-1 at μ = 0.01 M and 25 °C. The plot of log kψ versus pH for the decomposition reaction is linear with a unit slope in the pH range 1.77−6.50. The diperoxide B decomposes much more slowly to yield O2 and CH3ReO3. This is a minor pathway, however, amounting to <1% of the methanol and perrhenate ions produced from the irreversible deactivation at any given pH. Within the limited precision for this rate constant, it appears to vary linearly with [OH-] with k = 3 × 10-4 s-1 at pH 3.21, μ = 0.10 M, and 25 °C. Without peroxide, CH3ReO3 is stable below pH 7, but decomposes in alkaline aqueous solution to yield CH4 and ReO4-. As a consequence, the decomposition rate rises sharply with [H2O2], peaking at the concentration at which [A] is a maximum, and then falling to a much smaller value. Variable-temperature 1H NMR experiments revealed the presence of a labile coordinated water in B, but supported the anhydride form for A.
Food ingredients, cancer and foodomics (2016)

Resumen del trabajo presentado al XVI Latin-American Congress on Chromatography, celebrado en Lisboa (Portugal) del 5 al 9 de enero de 2016.
Static forces in a superconducting magnet bearing (1995)

Static levitation forces and stiffnesses in superconducting bearing consulting of concentric ring magnets and a superconducting YBaCuO ring are investigated, in the field-cooled mode a levitation force of 20 N has been achieved. The axial and radial stiffnesses have values of 15 N/mm and 10 N/mm, respectively. An arrangement with two hearings supporting a high speed shaft is now under development.
A Sequential Phase 2b Trial Design for Evaluating Vaccine Efficacy and Immune Correlates for Multiple HIV Vaccine Regimens (2011)

Five preventative HIV vaccine efficacy trials have been conducted over the last 12 years, all of which evaluated vaccine efficacy (VE) to prevent HIV infection for a single vaccine regimen versus placebo. Now that one of these trials has supported partial VE of a prime-boost vaccine regimen, there is interest in conducting efficacy trials that simultaneously evaluate multiple prime-boost vaccine regimens against a shared placebo group in the same geographic region, for accelerating the pace of vaccine development. This article proposes such a design, which has main objectives (1) to evaluate VE of each regimen versus placebo against HIV exposures occurring near the time of the immunizations; (2) to evaluate durability of VE for each vaccine regimen showing reliable evidence for positive VE; (3) to expeditiously evaluate the immune correlates of protection if any vaccine regimen shows reliable evidence for positive VE; and (4) to compare VE among the vaccine regimens. The design uses sequential monitoring for the events of vaccine harm, non-efficacy, and high efficacy, selected to weed out poor vaccines as rapidly as possible while guarding against prematurely weeding out a vaccine that does not confer efficacy until most of the immunizations are received. The evaluation of the design shows that testing multiple vaccine regimens is important for providing a well-powered assessment of the correlation of vaccine-induced immune responses with HIV infection, and is critically important for providing a reasonably powered assessment of the value of identified correlates as surrogate endpoints for HIV infection.
Laser rastering flow cytometry: fast cell counting and identification (2009)

We describe the concept of laser rastering flow cytometry, where a rapidly scanning laser beam allows counting and classification of cells at much higher rates than currently possible. Modifications to existing flow cytometers to implement the concept include an acousto-optic deflector, fast analog-to-digital conversion, and a two-step digital-signal-processing scheme that handles the high data rates and provides key assay information. Results are shown that prove the concept, demonstrating the ability to resolve closely spaced cells and to measure cells at rates more than an order of magnitude faster than on conventional flow-cytometer-based hematology analyzers.
Differences in cognitive performance in nondemented Parkinson’s disease: A latent profile analysis of cognitive subtypes (2018)

LPA is a very interesting method for the establishment of more homogeneous groups of PD patients based on their neuropsychological characteristics. Moreover, the distinction between different cognitive profiles will allow us to design interventions better adapted to each patient.
Ternary Phase Behavior of Milk Fat Fractions (1998)

Milk fat was sequentially crystallized from ethyl acetate into three major componentsa high melting fraction (HMF), a middle melting fraction (MMF), and a low melting fraction (LMF)in 12%, 34%, and 54% (w/w) yields, respectively. The phase behavior of mixtures of HMF, MMF, and LMF was studied using solid fat content vs temperature data. Binary and ternary phase diagrams of mixtures of the three components were constructed. Binary HMF−MMF mixtures displayed monotectic solution behavior, forming a solid solution, whereas both LMF−HMF and LMF− MMF binaries formed partial solid solutions. The LMF fraction interacted more strongly with MMF than with HMF. Ternary phase diagrams showed the complex interaction between the three components simultaneously. On average, monotectic solution behavior was observed in mixtures of the three fractions at temperatures between 0 and 15 °C and above 30 °C. A eutectic was observed between a MMF−HMF solid solution and LMF at 0 °C. At temperatures corresponding to the melting range of MMF (15 °C < T < 30 °C), complex solution behavior was observed, with strong interactions between MMF and LMF. Keywords: Milk fat; fractions; phase diagrams; solution behavior; mixed crystals
Methodology Development and Validation of Amphotericin B Stability by HPLC‑DAD (2019)

The high worldwide consumption of antibiotics and their complex impurity profiles has drawn the attention of the scientific community to the development and validation of stability methods for these drugs. Amphotericin B is an antibiotic that is a natural fermentation product of bacterium Streptomyces nodosus, used as a broad-spectrum antifungal agent, and is highly unstable. For this reason, the objective of this work is the development and validation of an indicative method of stability by high performance liquid chromatography (HPLC) associated to diode array detector (DAD) for amphotericin B (AMB). To achieve this, the chromatographic profiles of acid, basic, oxidative and thermal degradation caused by AMB exposure to water and light were verified by HPLC-DAD, using an isocratic method under the following conditions: C18 chromatographic column (200 4.6 mm-5 m), mobile phase composed of 65:35 of organic phase (methanol/ acetonitrile in 41:18)/aqueous phase (2.5 mmol L -1 of disodium edetate, pH 5.0), flow rate of 1.0 mL min -1 , injection volume of 20 L, column temperature 30 2 C and wavelength of 383 nm. After identification of these profiles, the method was validated according to recommendations of the International Conference on Harmonization guidelines, and then, the active pharmaceutical ingredient (API) peak purity grade, percentage of drug degradation, occurrence of impurities peak and its identification by mass spectrometry (MS) with electrospray ionization (ESI), under positive ionization mode, were evaluated. It is suggested that the main degradation products were amphotericin B (2), degradation product 1 (DP1) and degradation product 2 (DP2) in acid and oxidative medium. Amphotericin B was stable in the presence of water and at 70 2 C for seven days.
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release (2010)

Micelles are colloidal particles with a size around 5-100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a 'magic bullet' a major step forward.
A directed acyclic graph based detection for rbac based secure interoperation (2009)

Collaboration enables domains to share resources effectively; however it introduces several security and privacy challenges. To guarantee the secure interoperation in complex distributed environment, a RBAC based secure interoperation model was proposed. Based on the inherent characteristic of the RBAC system, a directed acyclic graph based detection method of security violation was investigated. We also classified the conflicts according to the feature of each four parts of NITS RBAC model: conflicts resulting from unrelated roles, conflicts that arise from related roles and conflicts due to separation of duty. The targeted detection method for different types of conflicts was illustrated systematically. Therefore corresponding detection method can be applied to different types of conflicts according to the actual application environment. Furthermore, we analyzed the algorithmic complexity of the method and demonstrated the application of the directed acyclic graph based detection method with case studies in realistic scenarios.
Single-stage automated assay for heparin. (1982)

We have developed a single-stage assay for heparin, using reagents modified from the two-stage Dade Protopath heparin synthetic substrate assay. The single-stage assay involves simultaneous mixing of a plasma sample, an antithrombin III source, alpha-thrombin, and the alpha-thrombin fluorogenic substrate. The synthetic substrate, antithrombin III, and heparin-antithrombin III complex compete for the alpha-thrombin active site. The alpha-thrombin is inactivated by the heparin-antithrombin complex while substrate is being hydrolyzed, so that total product formation decreases with heparin concentration. Day-to-day CV was 9.3% at a heparin concentration of 246 USP units/L. Comparison of results of the single-stage heparin assay with those of a two-stage esterolytic assay yielded the linear regression equation: esterolytic = 0.834 (single-stage)--7 USP units/L (r = 0.94, n = 47). Bilirubin interfered with the single-stage assay, resulting in an apparent increase in sample heparin concentration. The single-stage heparin assay can be automated for centrifugal analyzers capable of double-reagent addition and fluorometric detection, substantially decreasing reagent requirements and therefore costs.
Mammalian Kidney Development: Principles, Progress, and Projections (2012)

The mammalian kidney is a vital organ with considerable cellular complexity and functional diversity. Kidney development is notable for requiring distinct but coincident tubulogenic processes involving reciprocal inductive signals between mesenchymal and epithelial progenitor compartments. Key molecular pathways mediating these interactions have been identified. Further, advances in the analysis of gene expression and gene activity, coupled with a detailed knowledge of cell origins, are enhancing our understanding of kidney morphogenesis and unraveling the normal processes of postnatal repair and identifying disease-causing mechanisms. This article focuses on recent insights into central regulatory processes governing organ assembly and renal disease, and predicts future directions for the field.
30-Day Outcomes of Trans-Carotid Artery Revascularization with Proximal Protection Through ICA Flow Reversal in Neurosurgical Practice (2020)

Cord, Branden J MD, PhD; Santarosa, Corrado MD; Sujijantarat, Nanthiya MD; Koo, Andrew B; Elsamadicy, Aladine A BE; Sheth, Kevin; Falcone, Guido; Sansing, Lauren; Schindler, Joseph; Petersen, Nils; Matouk, Charles C MD Author Information
Supplementary Table S3A: Mutations by Gene from Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8<sup>+</sup>/PDL1<sup>+</sup> Immune Infiltration in Inflammatory Breast Cancer Tumors (2023)

&lt;p&gt;Gene mutation summary.&lt;/p&gt;
Temperature stability of (Pt/Co)3/IrMn multilayers (2012)

The effect of annealing on the structural stability of (Pt2nm/Co0.4 nm)3/IrMn7nm multilayers has been investigated using atom probe tomography. The composition of individual layers was measured after annealing at 300, 400, 500, and 700 °C. While results show that the (Pt/Co)3/IrMn stacking sequence is preserved up to 400 °C, there is an almost complete destruction of the multilayered structure when annealing at higher temperatures (500 and 700 °C). Co layers no more alternate with Pt-rich layers. The whole stack is transformed into an IrCo/PtMn bilayer. These results are interpreted on the basis of atomic mobilities and chemical affinities. Diffusion of Co and Mn is shown to become important when annealing temperature approaches 500 °C. Results are well accounted for by thermodynamics arguments considering the Co-Ir and Pt-Mn phase diagrams.