gebhart/patrepeval huggingface dataset:
Oregovomab Maintenance Monoimmunotherapy Does Not Improve Outcomes in Advanced Ovarian Cancer (2008)

Although oregovomab has demonstrated bioactivity, the strategy of monoimmunotherapy is not effective as maintenance therapy after front-line treatment of a favorable subset of patients with advanced ovarian cancer. Future studies of this or other tumor-antigen specific immunization strategies should seek ways to further augment induced immunity.
Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea (2012)

In this study we conducted a survey of the diversity and abundance of species of the genus Conus over two macrohabitats in the eastern rim of the Bismarck Archipelago at the northern tip of New Ireland province of Papua New Guinea. The main aim was to set a baseline for the future use of Conus species as a biodiversity indicator to monitor human impact and conservation efforts in this region. We observed 422 live cone snails on 10 reefs covering 30 different species, with an overall diversity index of 0.924. The two habitats displayed a 74% proportional similarity with an average Corms density of 24 +/- 9/ha (x +/- SD, total sampled surface area: similar to 0.652 km(2)). Corms flavidus, C. wiles, C. sanguinolentus., C. distans and C. litteratus were the five most abundant species. Night sampling at marine-protected Lissenung Island highlighted substantial differences between clay and night observations. Sampling at 30 m depth confirmed the presence of the recently identified C. moncuri in this area. Overall, genus Corms was strongly present in all of the sampled sites and represents a good low-cost indicator for long-term studies of human impact and facile comparison of the health of similar, but geographically distant ecosystems.
An effective FoV restriction approach to mitigate VR sickness on mobile devices (2018)

Abstract It has been noted that restricting field of view (FoV) is effective to mitigate virtual reality (VR) sickness, but it is prone to reduce the immersiveness. We propose an effective FoV restriction approach to mitigate VR sickness on mobile devices. The proposed approach includes a practical and reliable method for measuring VR sickness and a method of effectively limiting the FoV on mobile VR devices. Experimental result shows that the proposed method reduces VR sickness by 31.4%. The method was successfully applied to a VR application.
The Role of fosA in Challenges with Fosfomycin Susceptibility Testing of Multispecies Klebsiella pneumoniae Carbapenemase-Producing Clinical Isolates (2019)

With multidrug-resistant (MDR) <i>Enterobacterales</i> on the rise, a nontoxic antimicrobial agent with a unique mechanism of action such as fosfomycin seems attractive. However, establishing accurate fosfomycin susceptibility testing for non-<i>Escherichia coli</i> isolates in a clinical microbiology laboratory remains problematic. We evaluated fosfomycin susceptibility by multiple methods with 96 KPC-producing clinical isolates of multiple strains and species collected at a single center between 2008 and 2016. In addition, we assessed the presence of fosfomycin resistance genes from whole-genome sequencing (WGS) data using NCBI's AMRFinder and custom HMM search. Susceptibility testing was performed using a glucose-6-phosphate-supplemented fosfomycin Etest and Kirby-Bauer disk diffusion (DD) assays, and the results were compared to those obtained by agar dilution. Clinical Laboratory and Standards Institute (CLSI) breakpoints for <i>E. coli</i> were applied for interpretation. Overall, 63% (60/96) of isolates were susceptible by Etest, 70% (67/96) by DD, and 88% (84/96) by agar dilution. <i>fosA</i> was detected in 80% (70/88) of previously sequenced isolates, with species-specific associations and alleles, and <i>fosA</i>-positive isolates were associated with higher MIC distributions. Disk potentiation testing was performed using sodium phosphonoformate to inhibit <i>fosA</i> and showed significant increases in the zone diameter of DD testing for isolates that were <i>fosA</i> positive compared to those that were <i>fosA</i> negative. The addition of sodium phosphonoformate (PPF) corrected 10/14 (71%) major errors in categorical agreement with agar dilution. Our results indicate that <i>fosA</i> influences the inaccuracy of susceptibility testing by methods readily available in a clinical laboratory compared to agar dilution. Further research is needed to determine the impact of <i>fosA</i> on clinical outcomes.
Nickel-hydrogen CPV battery update (1993)

The multicell common pressure vessel (CPV) nickel hydrogen battery manufactured by Johnson Controls Battery Group, Inc. has completed full flight qualification, including random vibration at 19.5 g for two minutes in each axis, electrical characterization in a thermal vacuum chamber, and mass-spectroscopy vessel leak detection. A first launch is scheduled for late in 1992 or early 1993 by the Naval Research Laboratory (NRL). Specifics of the launch date are not available at this time due to the classified nature of the program. Release of orbital data for the battery is anticipated following the launch.
Minimizing channel density with movable terminals (2002)

Algorithms to minimize density for channels with terminals that are movable subject to certain constraints are given. The main cases considered are channels with linear order constraints, channels with linear order constraints and separation constraints, channels with movable modules containing fixed terminals, and channels with movable modules and terminals. In each case, previous results for running time and space are improved by a factor of L/lg n and L, respectively, where L is the channel length and n is the number of terminals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Zimbabwe's multi-currency economy and people's livelihoods: An examination of the impact of the strategy of remittances with reference to Zaka district 2009–2012 (2012)

In Zimbabwe's post-colonial period, political instability, unemployment rate and other economic hardships in general amplified the migration of Zimbabweans into other countries in search of greener pastures. The dawn of the Government of National Unity composed of the Zimbabwe African National Union Patriotic Front and the Movement for Democratic Change formations in 2009 culminated into the introduction of a multi-currency economy evident in the use of the United States dollar, the South African rand and Botswana pula. Using data collected through qualitative methodology, the study asserts that the migration of Zimbabweans to other countries resulted in remittances becoming a vital livelihood strategy. The study analyses the role remittances played on people's livelihoods and the people's perceptions towards remittances during the multi-currency era. It reveals that remittances contributed immensely in improving people's livelihoods before the introduction of the multi-currency system as they ensured access to the provision of basic needs. Indeed the significance and impact of remittances declined during the era of the multi-currency economy. It concludes there were mixed perceptions (both negative and positive) from inhabitants of Zaka District on the impact of the strategy of remittances on people's livelihoods during the multi currency economy.
Natural resolution of inflammation (2013)

Inflammation is a protective response essential for maintaining human health and for fighting disease. As an active innate immune reaction to challenge, inflammation gives rise to clinical cardinal signs: rubor, calor, dolor, tumor and functio laesa. Termination of acute inflammation was previously recognized as a passive process; a natural decay of pro-inflammatory signals. We now understand that the natural resolution of inflammation involves well-integrated, active, biochemical programs that return tissues to homeostasis. This review focuses on recent advances in the understanding of the role of endogenous lipid mediators that modulate cellular fate and inflammation. Biosynthesis of eicosanoids and other lipids in exudates coincides with changes in the types of inflammatory cells. Resolution of inflammation is initiated by an active class switch in lipid mediators, such as classic prostaglandins and leukotrienes, to the production of proresolution mediators. Endogenous pro-resolving lipid mediators, including arachidonic acid-derived lipoxins, aspirin-triggered lipoxins, ω3-eicosapentaenoic acid-derived resolvins of the E-series, docosahexaenoic acid-derived resolvins of the D-series, protectins and maresins, are biosynthesized during the resolution phase of acute inflammation. Depending on the type of injury and the type of tissue, the initial cells that respond are polymorphonuclear leukocytes, monocytes/macrophages, epithelial cells or endothelial cells. The selective interaction of specific lipid mediators with G protein-coupled receptors expressed on innate immune cells (e.g. G protein-coupled receptor 32, lipoxin A4 receptor/formyl peptide receptor2, chemokine-like receptor 1, leukotriene B4 receptor type 1 and cabannoid receptor 2) induces cessation of leukocyte infiltration; vascular permeability/edema returns to normal with polymorphonuclear neutrophil death (mostly via apoptosis), the nonphlogistic infiltration of monocyte/macrophages and the removal (by macrophages) of apoptotic polymorphonuclear neutrophils, foreign agents (bacteria) and necrotic debris from the site. While an acute inflammatory response that is resolved in a timely manner prevents tissue injury, inadequate resolution and failure to return tissue to homeostasis results in neutrophil-mediated destruction and chronic inflammation. A better understanding of the complex mechanisms of lipid agonist mediators, cell targets and actions allows us to exploit and develop novel therapeutic strategies to treat human inflammatory diseases, including periodontal diseases.
Role of pathogenicity island‐associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536 (2006)

The genome of uropathogenic Escherichia coli isolate 536 contains five well-characterized pathogenicity islands (PAIs) encoding key virulence factors of this strain. Except PAI IV(536), the four other PAIs of strain 536 are flanked by direct repeats (DRs), carry intact integrase genes and are able to excise site-specifically from the chromosome. Genome screening of strain 536 identified a sixth putative asnW-associated PAI. Despite the presence of DRs and an intact integrase gene, excision of this island was not detected. To investigate the role of PAI-encoded integrases for the recombination process the int genes of each unstable island of strain 536 were inactivated. For PAI I(536) and PAI II(536), their respective P4-like integrase was required for their excision. PAI III(536) carries two integrase genes, intA, encoding an SfX-like integrase, and intB, coding for an integrase with weak similarity to P4-like integrases. Only intB was required for site-specific excision of this island. For PAI V(536), excision could not be abolished after deleting its P4-like integrase gene but additional deletion of the PAI II(536)-specific integrase gene was required. Therefore, although all mediated by P4-like integrases, the activity of the PAI excision machinery is most often restricted to its cognate island. This work also demonstrates for the first time the existence of a cross-talk between integrases of different PAIs and shows that this cross-talk is unidirectional.
Poly-L-lactic acid for the treatment of trauma-induced facial lipoatrophy and asymmetry. (2008)

Poly-L-lactic acid (PLLA) is approved by the US Food and Drug Administration (FDA) for the treatment of human immunodeficiency virus (HIV)-associated lipoatrophy. Over the past several years, PLLA has been increasingly used as a treatment for lipoatrophy secondary to the natural process of aging. There have been no reports on the use of PLLA for trauma-induced facial lipoatrophy and asymmetry. In this article, we review the safety, effectiveness, treatment guidelines, mechanism of action, and quality-of-life (QOL) impact of PLLA. We present a patient with facial lipoatrophy and asymmetry secondary to injury from a motor vehicle accident that was effectively treated using PLLA. The future role of PLLA in the treatment of trauma-induced facial lipoatrophy and asymmetry, as well as other disorders, also is discussed.
<title>Evaluation Of Aerosol-Obscured Infrared Imagers</title> (1984)

Military infrared devices are vulnerable to a variety of countermeasures which must be qualitatively and quantitatively evaluated to assure effective application of the systems. Because of the high costs of field testing this equipment, attempts to create various environments for simulating battlefield conditions have evolved. We report on progress with a shortened real-world simulator and an instrumented field van used to provide validating real-world data. Both facilities are being used in the presence of obscuring aerosols to study the behavior of infrared imagers in the 2-14 micrometer bands. We discuss the capabilities of the facility and the nature of the measurements involved.
Guiding Architectural SRAM Models (2006)

Caches, block memories, predictors, state tables, and other forms of on-chip memory are continuing to consume a greater portion of processor designs with each passing year. Making good architectural decisions early in the design process requires a reasonably accurate model for these important structures. Dealing with continuously changing SRAM design practices and VLSI technologies make this a very difficult problem. Most hand-built memory models capture only a single parameterized design and fail to account for changes in design practice for different size memories or problems with wire scaling. Instead, in this paper we present a high level model that can be used to make simple analytical estimates. Our model is built using the characterization of almost 60 real memory designs from the past 15 years. Our model and the presented methodology can be used to calibrate even more detailed memory models for better accuracy. Despite all of the things that could have gone wrong over the past 15 years, we show that the memory density and delay can be estimated with simple and intuitive functions and we present a technique to automatically extract important scaling trends that can be used to make accurate estimates across a variety of technology and architectural parameters.
Non--binary error correcting codes with noiseless feedback, localized errors, or both (2006)

We investigate non--binary error correcting codes with noiseless feedback, localized errors, or both. It turns out that the Hamming bound is a central concept. For block codes with feedback we present here a coding scheme based on an idea of erasions, which we call the {\bf rubber method}. It gives an optimal rate for big error correcting fraction $\tau$ ($>{1\over q}$) and infinitely many points on the Hamming bound for small $\tau$. We also consider variable length codes with all lengths bounded from above by $n$ and the end of a word carries the symbol $\Box$ and is thus recognizable by the decoder. For both, the $\Box$-model with feedback and the $\Box$-model with localized errors, the Hamming bound is the exact capacity curve for $\tau <1/2.$ Somewhat surprisingly, whereas with feedback the capacity curve coincides with the Hamming bound also for $1/2\leq \tau \leq 1$, in this range for localized errors the capacity curve equals 0. Also we give constructions for the models with both, feedback and localized errors.
Towards Improved Real-Time Observability of Behind-Meter PhotoVoltaic Systems (2019)

The stochasticity in energy supply introduced by increased PV penetration in grid distribution systems can lead to frequent and sudden supply-demand imbalances, thereby causing voltage and frequency fluctuations. Enhanced observability, in real-time, of grid attributes such as real and reactive power flows, power injections/consumption and voltages is becoming increasingly essential to ensure smooth grid operation under these new large-scale PV integration scenarios. Two significant challenges prevent grid operators from achieving this objective: 1) Computational complexity of quasi-static time-series simulations, and 2) Partial observability of behind-meter grid assets. In this work, we take a step towards this objective by enhancing the observability of smart inverter equipped PV systems located behind AMI meters. Smart inverters convert the DC output of PV systems into real and reactive power, the ratio of which is governed by a power factor setting. This in turn is governed by the real-time voltage at its terminal, as per a pre-set volt/var curve. While it is possible to infer the power factor setting - thereby, real and reactive power injection of the PV system - at each time interval by quasi-static time series simulations, such methods are not scalable to large grid sizes. We propose to reduce the reliance on simulations by developing a deep neural network based data-driven model which predicts the time dependent power factors of the PV systems in the grid. The model uses a small amount of simulated data to learn the dependence of power factor on 1) load and apparent PV power injection (root mean square of real and reactive power) data, and 2) AMI net-load data (for BTM PV assets). Our results show that our model can predict power factors with mean absolute error of less than 6.2% under full observability scenario and under 8.6% under the partial observability scenario. Thus, our data-driven model can reduce the amount of simulations required to compute real and reactive injections from PV systems in the distribution system with or without complete information.
Camera for thermal imaging of semiconductor devices based on thermoreflectance (2004)

A thermal imaging camera suitable for use on micron-sized active semiconductor devices has been developed. Based on a visible light thermoreflectance technique, this camera achieves 50mK temperature sensitivity and sub-micron spatial resolution when imaging the top metal contact layer. By using a photodiode array, sensitivity is improved over what is possible with a CCD (Charge Coupled Device) based system. Thermal imaging results of an ultra small 10 micron diameter SiGe micro-cooler is also presented.
NMDA-Dependent Currents in Granule Cells of the Dentate Gyrus Contribute to Induction but Not Permanence of Kindling (1999)

Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices from kindled and normal rats. In agreement with previous studies, granule cells from kindled rats examined within 1 wk after the last of 3 or 30-35 generalized tonic-clonic (class V) seizures demonstrated an increase in the NMDA receptor-dependent component of the perforant path-evoked synaptic current. Within 1 wk of the last kindled seizure, NMDA-dependent charge transfer underlying the perforant path-evoked current was increased by 63-111% at a holding potential of -30 mV. In contrast, the NMDA-dependent component of the perforant-evoked current in granule cells examined at 2.5-3 mo after the last of 3 or 90-120 class V seizures did not differ from age-matched controls. Because the seizure-induced increases in NMDA-dependent synaptic currents declined toward control values during a time course of 2.5-3 mo, increases in NMDA-dependent synaptic transmission cannot account for the permanent susceptibility to evoked and spontaneous seizures induced by kindling. The increase in NMDA receptor-dependent transmission was associated with the induction of kindling but was not responsible for the maintenance of the kindled state. The time course of alterations in NMDA-dependent synaptic current and the dependence of the progression of kindling and kindling-induced mossy fiber sprouting on repeated NMDA receptor activation are consistent with the possibility that the NMDA receptor is part of a transmembrane signaling pathway that induces long-term cellular alterations and circuit remodeling in response to repeated seizures, but is not required for permanent seizure susceptibility in circuitry altered by kindling.
Synthesis of some nitrogen mustards (1999)

Department of Chemistry, Science College, Patna-800 005, India <em>Manuscript received 23 August 1990 revised 15 June 1998, accepted 19 August 1998</em> Several Mannich base nitrogen mustards have been synthesised by the condensation of 3-substitutcd-phthalimides and 4-suhstitutedphthalimides with <em>N-</em>bis(2-chloroethyl)amine in ethanol-formalin
Mechanisms regulating the expression, self‐maintenance, and signaling‐function of the bradykinin B2 and B1 receptors (2002)

Bradykinin (BK) is a potent short-lived effector belonging to a class of peptides known as kinins. It participates in inflammatory and vascular regulation and processes including angioedema, tissue permeability, vascular dilation, and smooth muscle contraction. BK exerts its biological effects through the activation of the bradykinin B2 receptor (BKB2R) which is G-protein-coupled and is generally constitutively expressed. Upon binding, the receptor is activated and transduces signal cascades which have become paradigms for the actions of the Galphai and Galphaq G-protein subunits. Following activation the receptor is then desensitized, endocytosed, and resensitized. The bradykinin B1 (BKB1R) is a closely related receptor. It is activated by desArg(10)-kallidin or desArg(9)-BK, metabolites of kallidin and BK, respectively. This receptor is induced following tissue injury or after treatment with bacterial endotoxins such as lipopolysacharide or cytokines such as interleukin-1 or tumor necrosis factor-alpha. In this review we will summarize the BKB2R and BKB1R mediated signal transduction pathways. We will then emphasize the relevance of key residues and domains of the intracellular regions of the BKB2R as they relate to modulating its function (signal transduction) and self-maintenance (desensitization, endocytosis, and resensitization). We will examine the features of the BKB1R gene promoter and its mRNA as these operate in the expression and self-maintenance of this inducible receptor. This communication will not cover areas discussed in earlier reviews pertaining to the actions of peptide analogs. For these we refer you to earlier reviews (Regoli and Barabé, 1980, Pharmacol Rev 32:1-46; Regoli et al., 1990, J Cardiovasc Pharmacol 15(Suppl 6):S30-S38; Regoli et al., 1993, Can J Physiol Pharmacol 71:556-557; Marceau, 1995, Immunopharmacology 30:1-26; Regoli et al., 1998, Eur J Pharmacol 348:1-10).
The role of self-involvement in the development of cardiovascular disease: A motivational analysis (2009)

Elaborating the reactivity hypothesis about the development of cardiovascular disease we posit that performance conditions having strong consequences for individuals' self-definitions and self-esteem can provide a severe health risk. Based on a recent application of motivational intensity theory to self-relevant performance conditions we argue that such performance conditions justify the mobilization of high resources for active coping. The result is high effort when self-relevant demands are difficult or individuals try to do their best in active coping. Given the systematic link between resource mobilization and cardiovascular reactivity, this leads to strong cardiovascular reactivity under these conditions, which in turn promotes the development of hypertension and cardiovascular disease. The results of a recent series of studies are discussed.