gebhart/patrepeval huggingface dataset:
Simultaneous Ranging and Self-Positioning in Unsynchronized Wireless Acoustic Sensor Networks (2016)

Automatic ranging and self-positioning is a very desirable property in wireless acoustic sensor networks, where nodes have at least one microphone and one loudspeaker. However, due to environmental noise, interference, and multipath effects, audio-based ranging is a challenging task. This paper presents a fast ranging and positioning strategy that makes use of the correlation properties of pseudonoise sequences for estimating simultaneously relative time-of-arrivals from multiple acoustic nodes. To this end, a proper test signal design adapted to the acoustic node transducers is proposed. In addition, a novel self-interference reduction method and a peak matching algorithm are introduced, allowing for increased accuracy in indoor environments. Synchronization issues are removed by following a BeepBeep strategy, providing range estimates that are converted to absolute node positions by means of multidimensional scaling. The proposed approach is evaluated both with simulated and real experiments under different acoustical conditions. The results using a real network of smartphones and laptops confirm the validity of the proposed approach, reaching an average ranging accuracy below 1 cm.
Image-Rejection Up-/Down-Converter LO Distribution Chain for 5G mm-wave Phased-Array Systems (2023)

This paper reports on a local-oscillator (LO) distribution chain suitable for 5G mm-wave image-rejection up-/down-converter. The chain consists of a single-ended-to-differential active converter, which achieves low phase and amplitude imbalance, minimizing the area occupation. Secondly, a frequency doubler is included in the frontend. Following, buffer amplifiers boost the second-harmonic amplitude extracted from the doubler, and a differential polyphase quadrature filter generates two I/Q couples of differential signals, such that four signals can feed two up- or down-converter mixers to achieve sideband suppression for up-conversion operations or image-rejection for down-conversion, respectively. The LO chain is suitable to be provided with an input signal ranging from 11.5 to 13.5 GHz and achieving outputs from 23 to 27 GHz with quadrature capabilities. Finally, the maximum single-ended saturated output power is −1 dBm at 26 GHz and stays above −3.2 dBm for the entire band.
Interview with Herbert W. Roesky (2014)

Herbert W. Roesky published his first paper in ChemComm in 1969. He reflects on his love of fluorine chemistry and the evolution of his research over the decades since. ChemComm Interviews
ChemInform Abstract: Regioselective and Enantioselective Metalation of a Tricarbonyl(η6‐ arene)chromium Complex Derived from 1,3‐Dihydroisobenzofuran. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A method of evolving novel feature extraction algorithms for detecting buried objects in FLIR imagery using genetic programming (2014)

In this paper we present an approach that uses Genetic Programming (GP) to evolve novel feature extraction algorithms for greyscale images. Our motivation is to create an automated method of building new feature extraction algorithms for images that are competitive with commonly used human-engineered features, such as Local Binary Pattern (LBP) and Histogram of Oriented Gradients (HOG). The evolved feature extraction algorithms are functions defined over the image space, and each produces a real-valued feature vector of variable length. Each evolved feature extractor breaks up the given image into a set of cells centered on every pixel, performs evolved operations on each cell, and then combines the results of those operations for every cell using an evolved operator. Using this method, the algorithm is flexible enough to reproduce both LBP and HOG features. The dataset we use to train and test our approach consists of a large number of pre-segmented image “chips” taken from a Forward Looking Infrared Imagery (FLIR) camera mounted on the hood of a moving vehicle. The goal is to classify each image chip as either containing or not containing a buried object. To this end, we define the fitness of a candidate solution as the cross-fold validation accuracy of the features generated by said candidate solution when used in conjunction with a Support Vector Machine (SVM) classifier. In order to validate our approach, we compare the classification accuracy of an SVM trained using our evolved features with the accuracy of an SVM trained using mainstream feature extraction algorithms, including LBP and HOG.
Rac‐Flurbiprofen is more ulcerogenic than its (S)‐enantiomer (1993)

The most common, and sometimes life-threatening, side-effects associated with the human use of the analgesic, nonsteroidal antiinflammatory drugs (NSAIDs) are gastrointestinal. These include gastritis, ulceration, and severe bleeding. The aryl propionic acid class of NSAIDs are among the most widely used of these drugs in the world, including rac-ibuprofen, rac-flurbiprofen, and rac-ketoprofen. Marketed as racemates, it was assumed that the "inactive" (R)-enantiomers, having no cyclooxygenase inhibiting effect, also had no toxic effect. In a 30-day dose response study of (S)-, (R)-, and rac-flurbiprofen given daily over a range of doses the (R)-isomer alone proved to be without apparent gastrointestinal (GI) toxicity. On the other hand the racemate proved to be 2 to 4 times as ulcerogenic in enantiomerically equivalent doses as the (S)-enantiomer. These results have significant clinical implications.
Fast Person Re-identification via Cross-Camera Semantic Binary Transformation (2017)

Numerous methods have been proposed for person re-identification, most of which however neglect the matching efficiency. Recently, several hashing based approaches have been developed to make re-identification more scalable for large-scale gallery sets. Despite their efficiency, these works ignore cross-camera variations, which severely deteriorate the final matching accuracy. To address the above issues, we propose a novel hashing based method for fast person re-identification, namely Cross-camera Semantic Binary Transformation (CSBT). CSBT aims to transform original high-dimensional feature vectors into compact identity-preserving binary codes. To this end, CSBT first employs a subspace projection to mitigate cross-camera variations, by maximizing intra-person similarities and inter-person discrepancies. Subsequently, a binary coding scheme is proposed via seamlessly incorporating both the semantic pairwise relationships and local affinity information. Finally, a joint learning framework is proposed for simultaneous subspace projection learning and binary coding based on discrete alternating optimization. Experimental results on four benchmarks clearly demonstrate the superiority of CSBT over the state-of-the-art methods.
Broad T-Cell Receptor Repertoire in T-Lymphocytes Derived from Human Induced Pluripotent Stem Cells (2014)

Human induced pluripotent stem cells (hiPSCs) have enormous potential for the treatment of inherited and acquired disorders. Recently, antigen-specific T lymphocytes derived from hiPSCs have been reported. However, T lymphocyte populations with broad T cell receptor (TCR) diversity have not been generated. We report that hiPSCs derived from skin biopsy are capable of producing T lymphocyte populations with a broad TCR repertoire. In vitro T cell differentiation follows a similar developmental program as observed in vivo, indicated by sequential expression of CD7, intracellular CD3 and surface CD3. The γδ TCR locus is rearranged first and is followed by rearrangement of the αβ locus. Both γδ and αβ T cells display a diverse TCR repertoire. Upon activation, the cells express CD25, CD69, cytokines (TNF-α, IFN-γ, IL-2) and cytolytic proteins (Perforin and Granzyme-B). These results suggest that most, if not all, mechanisms required to generate functional T cells with a broad TCR repertoire are intact in our in vitro differentiation protocol. These data provide a foundation for production of patient-specific T cells for the treatment of acquired or inherited immune disorders and for cancer immunotherapy.
New weighted-sum-of-gray-gases model for typical pressurized oxy-fuel conditions (2017)

Pressurized oxy-fuel combustion technology has received considerable attention due to its ability to improve the overall system efficiency and to control CO2 emissions. The characteristics of radiation heat transfer are significant for pressurized oxy-fuel gas mixture and different from those under atmospheric conditions. Therefore, to calculate the radiation characteristics of pressurized oxy-fuel gas mixture quickly and accurately, new weighted-sum-of-gray-gases (WSGG) model for pressurized oxy-fuel conditions was first presented in this paper, which was applied in 3 typical high pressure conditions: 5, 10, and 15 bar. The new WSGG model correlations were suitable for pressurized conditions with a molar ratio range of 0.125-2, temperature range of 400-2500 K, and path length range of 0.1-20 m. Calculations for a variety of typical pressurized oxy-fuel combustion cases showed that the new WSGG model can accurately predict the radiation characteristics and heat transfer characteristics of the gas mixtures compared with the SNB model benchmark. In addition, the application of the previous atmospheric WSGG models yielded non-ideal results under pressurized conditions. Consequently, the new model can provide efficient and accurate radiation heat transfer results for pressurized oxy-fuel conditions and can be used to design pressurized oxy-fuel combustion furnaces or boilers.
A novel strategy for phase balancing in three-phase four-wire distribution systems (2011)

This paper introduces a new strategy to reduce the phase unbalance of line currents in the three-phase four wire distribution networks and reducing the magnitude of neutral current by flat 50%. The proposed approach executes phase balancing by introducing new winding connections in the ordinary two-winding transformer and therefore it provides switch-less operation. The proposed approach is self sufficient and robust in itself such that it may relieve SCADA to take care about the phase unbalance produced in the distribution systems. The effectiveness of the proposed approach has been implemented on several load conditions. The simulation results show that the proposed approach is efficient and promising for phase balancing in distribution networks.
Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acids. (1984)

As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2, 3-dihydro-7H-pyrido [1, 2, 3-de] [1, 4] benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2, 3-dihydro-7H-pyrido [1, 2, 3-de] [1, 4] benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and-negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption (2015)

Background The meiotic cell cycle of mammalian oocytes starts during embryogenesis and then pauses until luteinizing hormone (LH) restarts the cycle. This meiotic arrest is maintained by cGMP, which is produced in the granulosa cells by C-type natriuretic peptide (CNP) activation of NPR2 [1]. LH decreases cGMP in the granulosa cells, and via equilibration through gap junctions, cyclic GMP also decreases in the oocyte, thus releasing the meiotic arrest [2]. LH causes dephosphorylation and inactivation of NPR2 [3,4], but whether NPR2 dephosphorylation is required for meiotic resumption is not known. Seven regulatory NPR2 phosphorylation sites have been identified (Fig. 1) [5,6]. Here, we generated a knock-in mouse where each site was mutated to glutamate (Npr2-7E), resulting in a “constitutively phosphorylated” enzyme that we used to investigate the role of NPR2 dephosphorylation in the rapid resumption of meiosis in response to LH.
Influence of A23187 and dibutyryl cyclic AMP on progestagen production by rat granulosa cells in vitro (1989)

The gonadotrophic regulation of progesterone production by rat granulosa cells was examined in a chemically-defined medium containing FSH, dibutyryl cyclic AMP [Bu)2cAMP) and the calcium ionophore, A23187. FSH and A23187 alone significantly enhanced the production of pregnenolone, progesterone and its metabolite, 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OH-P) from endogenous substrate(s). Stimulation of progesterone production by A23187 was accompanied by an increase in 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) but not 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) activity, as attested by enhancement of the metabolism of exogenous pregnenolone to progesterone but not of progesterone to 20 alpha-OH-P. In contrast, although (Bu)2cAMP increased pregnenolone and progesterone production and the metabolism of exogenous progesterone to 20 alpha-OH-P, it failed to stimulate the conversion of exogenous pregnenolone to progesterone. The increase in progesterone production and in the conversion of exogenous pregnenolone to progesterone by FSH and A23187 was concentration- and time-dependent. Whereas maximal stimulation of de-novo progesterone synthesis by FSH was evident by 6 h (earliest time examined), a significant increase in the conversion of exogenous pregnenolone to progesterone in the presence of FSH or the ionophore was not noted until 12 h of incubation. Although a small but significant increase in progesterone production was also noted as early as 6 h of incubation in the presence of the calcium ionophore, this was markedly smaller than that elicited by FSH. We conclude that the calcium ionophore A23187 and (Bu)2cAMP have similar as well as distinct effects on progesterone production in rat granulosa cells in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)
Device Design of Nanoscale MOSFETs Considering the Suppression of Short Channel Effects and Characteristics Variations (2007)

The device design of future nanoscale MOSFETs is reviewed. Major challenges in the design of the nanometer MOSFETs and the possible solutions are discussed. In this paper, special emphasis is placed on the combination of new transistor structures that suppress the short channel effect and on back-gate voltage control that suppresses the characteristics variations. Two new device architectures, variable-body-factor FD SOI MOSFET and multigate MOSFET with low aspect ratio, have been proposed and their advantages are discussed.
Retinoic Acid inhibits epidermal differentiation when applied topically on the stratum corneum of epidermis formed in vitro by human keratinocytes grown on defined medium (1997)

There is no doubt that retinoids have profound physiological and pharmacologic effects on epidermal differentiation and maintenance. However, the response of keratinocytes to retinoic acid (RA) is strikingly different whether they are cultured in vitro or whether epidermis is treated topically in vivo. In vitro, RA is able to inhibit completely the appearance of several epidermal-specific markers and to induce the ectopic appearance of several markers of nonkeratinized stratified epithelia, suggesting that a metaplasia has occurred. On the contrary, RA applied in vivo does not inhibit keratinization but provokes an increase of several markers of epidermal differentiation, while still inducing the expression of markers of nonkeratinized epithelia. The work presented in this paper shows that these different behaviors of the keratinocytes in vivo and in vitro are genuine, and not due to the fact that in vitro retinoids were added to the culture medium ("systemically"), before keratinization of the cultures, and in the presence of fetal calf serum and dermal components, while in vivo they were applied topically on the stratum corneum. We show that the "in vitro behavior" persists when retinoids are applied topically on the stratum corneum of keratinocyte cultures performed in defined medium on inert filters, suggesting that there are unexplored crucial regulatory pathways involved in the cutaneous response to retinoids in vivo.
<title>Detection of linear objects for synthetic vision applications</title> (1996)

This paper describes an approach to find linear objects, e.g. powerlines and runways for synthetic vision applications with a multifunction 35 GHz radar. The approach is based on a combination of traditional radar signal processing like the CFAR-algorithm and image processing techniques like the Hough transform. It is assumed that the objects are visible as a sequence of single reflectors on a line. The proposed method ensures that the probability of detection or the false alarm rate of a linetype object is independent of the position. In the first step, a CFAR-algorithm detects the possible points along the line. All detected objects are describes by a list of attributes, from which some relevant ones can be chosen. Subsequently they are transformed to the Hough space, where lines are described by a slope and a distance parameter. A threshold is calculated which ensures a constant false alarm rate or a constant probability of detection. In the next step a cluster algorithm with a special distance measure is used to find all possible lines in the Hough-space. After transforming back to the original space, the plausibility is checked and a final selection is done. The performance of the approach is shown by applying the method described above to simulated and measured data. The paper describes the calculation of the false alarm rate, the probability of detection and the calculation of the threshold.
Estimation of the Genotoxicityof Hydrogen Peroxide and Antioxidant Actionof Halo Acid by the Method of Dna-Cometwith the Use of the Model of Transplantable Cell Cultures (2018)

In the framework of the study, the degree of defragmentation of DNA by the DNA-comet method is evaluated when exposed to the cell culture of hydrogen peroxide (H2O2), and an in vitro model is developed to evaluate the antioxidant activity of new pharmacological agents. The results of working with cell lines show that the percentage of damage to the genetic material of cells of intact samples does not greatly vary from the method of removing the cellular monolayer from the culture plastic. Concerning the effect of H2O2 as an inducer of oxidative stress on DNA cell damage, the optimal level of DNA defragmentation has been modeled for subsequent studies of the protective action of antioxidants.
Factors correlating with serum birch pollen IgE status in pregnant women in Hokkaido, Japan: The Japan Environment and Children's Study (JECS) (2020)

UMIN000030786.
Encoding Strategies for Combinatorial Libraries (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Cytostatic effect of interferon-gamma and monocyte against a human carcinoma cell line. (1985)

Human interferon gamma (IFN-gamma) and normal peripheral blood monocytes had appreciable anticellular activities against KB cells such that in both cases, the rate of DNA synthesis, the number and percent viability of the cells were greatly reduced by 70-85% in about 3 days post-treatment. However, neither IFN-gamma nor monocyte alone was able to totally eliminate the tumor cells. Our results suggest that IFN-gamma and monocyte could effectively prevent the growth of residual tumor cells that would have escaped destruction when only one effector element was present.
Kidney Function and Cognitive Decline in Older Adults: Examining the Role of Neurodegeneration (2020)

We did not find a mild to moderate renal insufficiency to be associated with brain imaging features of AD, and our results do not support the involvement of AD mechanisms in the incidence of cognitive impairment and functional decline associated with chronic kidney disease.
Abstract 4650: From bench to bedside: are cytokines still relevant biomarkers for staging cancer cachexia. (2013)

Abstract Background: We have provided initial evidence1 on the clinical usefulness of the cancer cachexia stages (CCS) proposed by Fearon et al2. However it is still unclear3 if particular molecular phenotypes are also associated with these stages, as well with relevant clinical outcomes. Methods: A candidate list of cytokines (Activin A, Eotaxin, FGF, G-CSF, GDF15, GM-CSF, IFN-g, IL-10, IL-12_p70, IL-13, IL-15, IL-17, IL-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IP-10, MCP-1_MCAF, MIP-1a, MIP-1b, PDGF-bb, RANTES, TNF-a, VEGF) was measured in 210 blood samples from patients with advanced lung and gastrointestinal cancers, via Luminex and ELISA methods. Non-parametric t-test, Kaplan-Meier and Kruskal-Wallis analyses were used to test the association between cytokines levels with CCS, Patient-Generated Subjective Global Assessment scores (PG-SGA) and survival. Results: Using non-cachectic patients as controls, Activin A and GDF15 were significantly up-regulated in pre-cachectic (p&amp;lt;0.01), cachectic (p&amp;lt;0.05) and refractory cachectic (p&amp;lt;0.001) patients. IL-6, IL-8 and VEGFa were significantly up-regulated only in refractory cachectic (p&amp;lt;0.001) patients. Activin A (p&amp;lt;0.001), GDF15 (p&amp;lt;0.001) and IL-8 (P&amp;lt;0.001) plasma levels correlated with PG-SGA. Quartiles of GDF15 plasma levels identified better survival curves as compared to Activin A, IL-6 and IL-8 quartiles. Conclusions: Activin A and GDF15 appear to be useful aids for the diagnosis of all cachexia stages in advanced cancer. Because of their correlation with nutritional and survival outcomes, these cytokines may also represent useful targets in the development of new compounds for the treatment of cancer cachexia. 1. Vigano A, Del Fabbro E, Bruera E, Borod M. The cachexia clinic: from staging to managing nutritional and functional problems in advancer cancer patients. Critical Reviews in Oncogenesis, 2012 17(3), 293-304 2. Fearon K,Strasser F,Anker SD,Bosaeus I,Bruera E,Fainsinger RL,Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011; 12:489-495. 3. Scheede-Bergdahl, C., Watt, H.L., Trutschnigg, B., Kilgour, R.D., Haggarty, A., Lucar, E., Vigano, A. 2011. Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia? Clinical Nutrition 31: 85-8. Citation Format: Antonio Vigano, Lorena Lerner, Nianjun Tao, Brian Krieger, Bin Feng, Richard Nicoletti, Qing Liu, Ailin Bai, Zhigang Weng, Thierry Alcindor, Domenico Fuoco, Jeno Gyuris, Maria Isabel Chiu. From bench to bedside: are cytokines still relevant biomarkers for staging cancer cachexia. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4650. doi:10.1158/1538-7445.AM2013-4650