gebhart/patrepeval huggingface dataset:
Structural Elucidation of a 2:2 4-Ketoaldehyde−Amine Adduct as a Model for Lysine-Directed Cross-Linking of Proteins by 4-Ketoaldehydes (1999)

4-Ketoaldehydes react with lysine-based amines to form the same pyrroles that form in low yield by treatment of proteins with 4-hydroxy-2-alkenals generated endogenously during lipid peroxidation. Since pyrroles are susceptible to oxidative coupling, it has been presumed that the cross-linking of proteins observed for 4-ketoaldehydes involves the intermediacy of the corresponding lysine-derived pyrroles. However, the monoalkylpyrroles generated from simple 4-ketoaldehydes do not exhibit oxidative coupling within the time frame that 4-ketoaldehydes induce substantial protein cross-linking. Model studies have revealed that a side reaction competes with the formation of pyrroles from 4-ketoaldehydes and amines. In this paper, we show that this side reaction involves a non-redox aldol-like condensation process resulting in 2:2 adducts, which have been structurally characterized as isomeric pyrrolo[3.2. 1]azabicyclooctanes. Formation of these 2:2 adducts in competition with pyrrole formation is proposed to represent the major pathway for rapid lysine-dependent cross-linking of proteins by simple 4-ketoaldehydes.
Impact Ionization in Thin Silicon Diodes (2004)

We study the breakdown behavior of thin, abrupt silicon pin-diodes, using a low-power optical technique which can directly measure the avalanche multiplication factors even in the presence of large tunneling currents. Our measurements agree with a simple model for nonlocal avalanche generation, and we use this model to extend the breakdown predictions to a broad class of doped diodes similar to those found in the base-collector region of bipolar devices. Based on this analysis, we make quantitative estimates for the BV/sub CEO/ breakdown of modern Si and SiGe high-speed bipolar transistors.
Supplementary material to "On the spatial organization of the ridge slough patterned landscape" (2015)

Table For each site, we give the total number of data points in each empirical 4 distribution, n, along with the maximum patch area, max x. For the Monte Carlo p-5 values panel, we give the corresponding p-values for the Monte Carlo tests. Significant 6 values (p > 0.1) are denoted in bold, and represent a data set being consistent with 7 Monte Carlo tests (site j for the log-normal did not converge on a result). p-values 8 corresponding to the log-likelihood ratio tests are also given, with statistically significant 9 values (p < 0.1) represented in bold (if a value is significant, it is considered a poor fit in 10 comparison to the alternate distribution). The panel on the right gives parameter values 11 corresponding to the GP.
Development of a Microchannel High Temperature Recuperator for Ultra-High Efficiency Fuel Cell/Turbine Systems (2012)

FuelCell Energy (FCE) is developing microchannel high temperature recuperators and system concepts supporting high temperature fuel cell/turbine hybrid systems. Under this initiative recuperator candidate materials are screened and tested for strength and environmental resistance for high temperature, high humidity conditions. The program involves fabrication and testing of pilot-scale recuperators and will culminate in a MW-duty recuperator design supporting FCE's development toward a commercial MW-scale hybrid system. Recuperator designs are being developed for molten carbonate fuel cell (MCFC) and solid oxide fuel cell (SOFC) systems that integrate unfired gas turbines powered by waste heat recovered by a high temperature recuperator (HTR). Cost-of-electricity sensitivity analyses have been carried out on a MW-scale solid oxide fuel cell/turbine (SOFC/T) concept to establish system/recuperator optimal parameters and cost targets. A pilot-scale (15 kW duty) SOFC/T HTR has been designed along with an associated 1/20 scale trial component for initial testing.
Least squares QR-based decomposition provides an efficient way of computing optimal regularization parameter in photoacoustic tomography (2013)

A computationally efficient approach that computes the optimal regularization parameter for the Tikhonov-minimization scheme is developed for photoacoustic imaging. This approach is based on the least squares-QR decomposition which is a well-known dimensionality reduction technique for a large system of equations. It is shown that the proposed framework is effective in terms of quantitative and qualitative reconstructions of initial pressure distribution enabled via finding an optimal regularization parameter. The computational efficiency and performance of the proposed method are shown using a test case of numerical blood vessel phantom, where the initial pressure is exactly known for quantitative comparison.
Supplementary Figure 4 from Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma (2023)

&lt;p&gt;Supplementary Figure 4. Wnt-β-catenin and EGFR-AKT pathways in glioma.&lt;/p&gt;
Direct detection of a single photon by humans (2016)

Despite investigations for over 70 years, the absolute limits of human vision have remained unclear. Rod cells respond to individual photons, yet whether a single-photon incident on the eye can be perceived by a human subject has remained a fundamental open question. Here we report that humans can detect a single-photon incident on the cornea with a probability significantly above chance. This was achieved by implementing a combination of a psychophysics procedure with a quantum light source that can generate single-photon states of light. We further discover that the probability of reporting a single photon is modulated by the presence of an earlier photon, suggesting a priming process that temporarily enhances the effective gain of the visual system on the timescale of seconds.
Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant (2004)

The plasmid encoding IL-18 together with HBV M gene DNA vaccines may enhance specific TH1 cells and CTL cellular immune response induced in mice, so that IL-18 is a promising immune adjuvant.
Solubility, Permeability, and Their Interplay (2018)

After oral administration, absorption of the drug from the dosage form depends on the release of the substance from the product, the dissolution/solubilization of the drug under physiological conditions, and the permeability throughout the gastrointestinal tract. Increasing the solubility or permeability of drugs represents a major challenge in the early stages of drug discovery. The biopharmaceutics classification system (BCS) offers guidelines for classification and may allow the identification of the steps necessary for improving the overall bioavailability of a given drug. In this chapter, we present the key factors dictating oral drug absorption; some of the approaches for solubility and permeability enhancement as well as the interplay between the two when using solubility-enabling drug formulations are introduced. The overview presented in this chapter highlights that the absorption of drugs, their effective delivery, and consequently their pharmacological effect are largely influenced by solubility and permeability. Moreover, it is essential to consider their interplay and to strike the optimal solubility–permeability balance in order to increase the overall drug absorption and bioavailability and maximize the chances of successful clinical development.
Slot-Die Process of a Sol–Gel Photocatalytic Porous Coating for Large-Area Fabrication of Functional Architectural Glass (2021)

The slot-die process is an appealing technology for the fabrication of coatings on large-area substrates. However, its application on the production of photocatalytic coatings based on sol–gel formulations remains virtually unexplored. Thus, assessing the suitable formulation of the sol and operational parameters that allow one to yield high-efficacy photocatalyst coatings is a current challenge. This work aims to analyze the transferability of titania sol formulation optimized for dip-coating processes to slot-die technology. In this sense, firstly, the sol formulation is optimized by analyzing the influence of several types of surfactants on the microstructural features and photoactivity of TiO2 coatings’ growth on glass substrates. All formulations rendered a meaningful porosity and nanoscopic anatase crystallites (11–15 nm) with optical band gap values close to the expectation (3.25–3.31 eV). Accordingly, the performance of the photocatalytic dye degradation was closely related to the porosity and crystallite size led by each titania sol, and no meaningful differences were found between the results provided by the coatings developed by dip-coating and the slot-die method, which demonstrates the capability of the latter for its application on a large-scale fabrication of photocatalytic coatings.
Deletion of the cytoplasmic region of the CD3 epsilon subunit does not prevent assembly of a functional T-cell receptor. (1989)

The T-cell receptor (TCR) is a molecular complex comprised of a clonally restricted, immunoglobulin-like heterodimer (Ti), responsible for specific antigen recognition, and a set of monomorphic polypeptide CD3 subunits, termed gamma, delta, epsilon, zeta, and eta, presumed to be involved in transmembrane signaling events. To investigate the role of the CD3 epsilon subunit in signal transduction, we have transfected a murine hybridoma T-cell line with either wild-type or variant human CD3 epsilon cDNA that encodes a protein lacking 49 of the 55 cytoplasmic amino acid residues. Both wild-type and truncated CD3 epsilon human proteins assemble with endogenous murine CD3/Ti subunits to form functional surface TCRs: Anti-human CD3 epsilon monoclonal antibodies bind exclusively to these chimeric TCRs and trigger interleukin 2 production from the murine cells. Thus, the CD3 epsilon cytoplasmic domain is not required for assembly of the multimeric TCR. Furthermore, it is dispensable for the transduction of a stimulus delivered to the external part of the molecule, suggesting that interaction between the transmembrane and/or external regions of the other TCR chains is a prerequisite for transmembrane signaling.
Stability of valganciclovir in extemporaneously compounded liquid formulations (2003)

Journal Article Stability of valganciclovir in extemporaneously compounded liquid formulations Get access Carolyn C. Henkin, Pharm.D., BCPS, Carolyn C. Henkin, Pharm.D., BCPS Clinical Pharmacist Department of Pharmacy, Children’s Medical Center of Dallas (CMCD), Dallas, TX Address correspondence to Dr. Henkin at the Department of Pharmacy, Children’s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235 chenki@childmed.dallas. tx.us. Search for other works by this author on: Oxford Academic Google Scholar James C. Griener, Pharm.D., James C. Griener, Pharm.D. Associate Professor Department of Pharmacy Practice, School of Pharmacy, Texas Tech, Dallas Search for other works by this author on: Oxford Academic Google Scholar Andrew P. Ten Eick, Pharm.D. Andrew P. Ten Eick, Pharm.D. Manager Department of Pharmacy, Pediatric Intensive Care Unit, CMCD Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 60, Issue 7, 1 April 2003, Pages 687–690, https://doi.org/10.1093/ajhp/60.7.687 Published: 01 April 2003
Dependence of impurity zero-phonon thermal broadening on vibron level in organic crystals: A manifestation of the crystal anharmonicity (1974)

Thermal broadening data on the zero-phonon impurity bands in the 4500 Å 1B1 ← 1A1 and 3500 Å 1A1 ← 1A1 absorption systems of 1,3-diazaazulene and azulene in a naphthalene host are reported. For both systems, a marked dependence of the thermal broadening on the final impurity vibron level of the transition is observed. The broadening for all fundamental vibron bands studied is smaller than the broadening of the origin or zero-vibron band. This fact allows one to attribute the above vibron level dependence to a specific anharmonic interaction term (a quartic mixed vibron-phonon term). It is this term which describes the dependence of the quadratic off-diagonal electron-phonon coupling on impurity vibron level. Apparently the vibron-phonon anharmonic terms which lead to temperature dependent vibron relaxation processes are negligible. We report also the unexpected observation of a dependence of zero-phonon band thermal broadening on crystal samples. No correlation between this dependence and residual widths is observed.
LA RUTA DE CERTIFICACIÓN DEL ESPAÑOL (2003)

SOBRE LA CERTIFICACION DEL IDIOMA ESPANOL QUE REALIZA EL CENTRO DE ENSENANZA PARA EXTRANJEROS (CEPE) MEDIANTE EL EXAMEN DE POSESION DE LA LENGUA ESPANOLA (EPLE), HABLA ROSARIO GUTIERREZ HACES, ACADEMICA DE ESTE CENTRO UNIVERSITARIO. EXPLICA QUE EL EPLE ES UN INSTRUMENTO QUE DETERMINA EL NIVEL DE DOMINIO DE LA LENGUA DE AQUELLAS PERSONAS INTERESADAS EN OBTENER LA CERTIFICACION DE POSESION DE LA LENGUA, INDEPENDIENTEMENTE DE LA FORMA EN QUE HAYA SIDO ADQUIRIDA; NO DEMUESTRA EL RESULTADO DE NINGUN CURSO ESPECIFICO PUESTO QUE EL INTERESADO PUDO HABER OBTENIDO LOS CONOCIMIENTOS DE DIVERSOS MODOS. EST  DIRIGIDO A PERSONAS ADULTAS QUE DESEAN O NECESITAN DEMOSTRAR SU NIVEL DE LENGUA. EL NIVEL DE DOMINIO ALCANZADO EST  EN ESTRICTA RELACION CON CADA UNA DE LAS HABILIDADES LINGISTICAS: EXPRESION ORAL, EXPRESION ESCRITA, COMPRENSION AUDITIVA Y COMPRENSION DE LECTURA. CON BASE EN ESTE EXAMEN, EL CEPE-UNAM OTORGA UNA CERTIFICACION DE COMPETENCIA LINGISTICA QUE PERMITE CONTAR CON UN INDICADOR DE LA ACTUACION DEL CANDIDATO PAR DESENVOLVERSE EN TODA CLASE DE SITUACIONES, TANTO DE TIPO SOCIAL COMO ACADEMICO Y LABORAL. EL CEPE EXPIDE UNA CERTIFICACION CON LOS RESULTADOS OBTENIDOS EN EL EXAMEN Y UNA DESCRIPCION DEL NIVEL ALCANZADO. PARA AQUELLOS CANDIDATOS QUE HAYAN OBTENIDO UN PUNTAJE SUPERIOR A 700 PUNTOS SE EXPIDE UN DIPLOMA. EL CEPE EN LA CIUDAD DE MEXICO ES EL UNICO RESPONSABLE DE LA EVALUACION DEL EXAMEN Y DE EMITIR LOS RESULTADOS.
Systemic lymphoblastoid interferon therapy in chronic progressive multiple Sclerosis. I. Clinical and MRI evaluation (1990)

A randomized, double-blind, placebo-controlled, noncrossover trial determined the efficacy of lymphoblastoid interferon (IFN) in chronic progressive multiple sclerosis (CP MS). Fifty patients received 5 X 10(6) IU IFN subcutaneously daily for 6 months while 50 received placebo. After 2 years, there were no significant differences between the 2 groups based on clinical evaluations and quantitative MRI analysis of the brain, although a trend was observed in the IFN group. Clinically, the IFN group was worse at 1 and 3 months and improved at 6 to 18 months, when compared with the placebo group. Results of MRI evaluations of the brain at 6 months support this trend. This trend likely resulted from a subpopulation of 10 IFN-treated patients, characterized by a higher women:men ratio and a lower EDSS score at entry into the trial. We cannot recommend lymphoblastoid IFN as treatment for CP MS at this time.
A smart partial discharge classification SOM with optimized statistical transformation feature (2021)

Condition-based monitoring (CBM) has been a vital engineering method to assess high voltage (HV) equipment and power cables conditions or health levels. One of the effective CBM methods is partial discharge (PD) measurement or detection. PD event is the phenomenon that always associated with insulation healthiness. PD has been measured and evaluated in this paper to discriminate PD signals from a good signal. A mixed-signal being fed at an AI technique with statistical modified input data to do fast classification (less than five seconds) with nearly zero error. In this paper, an unsupervised neural network is applied for PD classification. The methods combine the self-organizing maps (SOMs) and feature statistical transformation. By the combination of these methods, the ‘range’ normalization method produced the best classification outcomes. This development decided that PD information was effectively correlated and grouped by means of MATLAB’s SOM Toolbox and transformation device to discriminate the normal signal from the PD signal.
Selective deficiency of a T cell subpopulation in active atopic dermatitis. (1980)

The T cell subpopulation bearing a receptor for the Fc fragment of IgM (T mu) or the Fc fragment of IgG (T gamma) were studied in 12 patients with active atopic dermatitis (AD) and elevated IgE (5678 I.U./ml +/- 1382) and compared with a control group with normal IgE (33 +/- 17). Values for the total lymphocytes and for absolute and relative numbers of total T and T mu cells were comparable in both groups. However, AD patients had markedly reduced relative T gamma levels, 1.8% +/- 0.4%, compared with normals, 10.5% +/- 0.7% (p less than 0.001). The patients also had reduced absolute T gamma levels, 29 +/- 7, compared with 181 +/- 36 (p less than 0.0005). This abnormality was not indicative of allergic disease in general, nor did it appear to be caused directly by serum factors. The T gamma cell deficit did reflect disease activity and correlated inversely with the levels of serum IgE in the AD patients. Thus, patients with active AD and elevated IgE have a selective reduction in circulating T gamma cells.
The significance of regulatory T cells and cytokines secreted by regulatory T cells in aplastic anemia (2012)

Objective:To investigate the pathogenesis-related immunological mechanisms of T cell subsets in aplastic anemia by dectecting ratio of T cell subsets and the level of cytokines secreted by Treg cells.Methods:Basing on clinical diagnostic criteria,the peripheral blood samples of aplastic anemia were gathered from the initial issuance,the hematopoietic recovery and normal controls.The proportion of CD4+,CD8+,NK,NKT,Treg cells were counted by FACS respectively.The Treg cells of samples were separated by immunomagnetic beads and observed by stimulating factors.The supernatants were then collected after 24 or 48 hours.Enzyme-linked immunosorbent assay(ELISA) was applied to examine the expression of IL-10,IL-35 and TGF-β secreted by Treg cells.Results:The proportion of CD4+,Treg cells in the initial issuance was the lowest among the groups.The result was statistically significant(P0.05) that the proportion of CD8+ T cells was significantly higher in patients with aplastic anemia.There was no statistical difference in NK,NKT cells between aplastic anemia and normal controls(P0.05).The culture supernatant in ELISA showed that the expression of IL-10,IL-35 and TGF-β was significantly lower(P0.05) in the initial cases compared to the normal controls.Conlusion: Dysimmunity of T cells is a significant link in the aplastic anemia pathogenesis.Treg cells may play a positive regulatory role in the process of hematopoietic function recovery of aplastic anemia patients.
EFFECTS OF DROPERIDOL ON ACTIVITY OF CAROTID BODY CHEMORECEPTORS IN CAT (1978)

The effect of droperidol on the spontaneous activity of carotid body chemoreceptors and on their response to various stimuli was studied in 21 anaesthetized, paralyzed and artificially ventilated cats. Carotid body blood flow was controlled with a perfusion pump, and drugs were injected into the perfusion circuit. In low doses, droperidol transiently increased the rate of spontaneous chemoreceptor activity, but in higher doses it depressed chemoreceptor activity after an initial stimulation. Droperidol reduced or abolished the normal increase in chemoreceptor activity produced by stagnant asphyxia. This effect did not depend solely on the ability of droperidol to suppress spontaneously occurring impulses. Chemoreceptor responses to sodium cyanide, and to dopamine were also inhibited. Dopamine antagonists other than droperidol were also studied for their effect on chemoreceptor activity. Chlorpromazine depressed spontaneous chemoreceptor activity and also reduced the chemoreceptor responses to sodium cyanide and dopamine, as did pimozide. The effects of these dopamine antagonists were much briefer and less marked than those of droperidol. Although the influence that we have shown droperidol to have on peripheral chemoreceptor activity has an uncertain basis, it may have important implications in human and veterinary medicine.
Anions in Supramolecular Chemistry: Binding, Sensing, and Assembly (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A 298-fJ/writecycle 650-fJ/readcycle 8T Three-Port SRAM in 28-nm FD-SOI Process Technology for Image Processor (2016)

This paper presents a low-power and low-voltage 64-kb 8T three-port image memory using a 28-nm FD-SOI process technology. Our proposed SRAM accommodates eight-transistor bitcells comprising one-write/two-read ports and a majority logic circuit to save active energy. The test chip can operate at a supply voltage of 0.46 V and an access time of 140 ns. The energy minimum point is a supply voltage of 0.54 V and an access time of 55 ns (= 18.2 MHz), at which 298 fJ/cycle in a write operation and 650 fJ/cycle in a read operation are achieved with the help of the majority logic; these factor are 87% and 52% smaller than those in a 28-nm FD-SOI 6T SRAM.
Local Treatment of Kaposi Sarcoma of the Conjunctiva (2011)

Kohanim, Sahar MD; Daniels, Anthony B. MD, MSc; Huynh, Nancy MD; Chodosh, James MD, MPH Author Information
ChemInform Abstract: Small Molecule Inhibition of Microbial Natural Product Biosynthesis — An Emerging Antibiotic Strategy (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors (2010)

Following the recent discovery and development of 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin dependent kinase (CDK) inhibitors, a program was initiated to evaluate related ring-constrained analogues, specifically, 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines for inhibition of CDKs. Here we report the rational design, synthesis, structure-activity relationships (SARs), and cellular mode-of-action profile of these second generation CDK inhibitors. Many of the analogues from this chemical series inhibit CDKs with very low nanomolar K(i) values. The most potent compound reported in this study inhibits CDK2 with an IC(50) of 0.7 nM ([ATP] = 100 microM). Furthermore, an X-ray crystal structure of 2-methyl-N-(3-(nitro)phenyl)-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amine (11g), a representative from the chemical series in complex with cyclin A-CDK2, is reported, confirming the design rationale and expected binding mode within the CDK2 ATP binding pocket.