gebhart/patrepeval huggingface dataset:
A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia (2007)

The study's objective was to identify HPA 1a-negative women and to offer them an intervention program aimed to reduce morbidity and mortality of neonatal alloimmune thrombocytopenia (NAIT). HPA 1 typing was performed in 100 448 pregnant women. The HPA 1a-negative women were screened for anti-HPA 1a. In immunized women, delivery was performed by Cesarean section 2 to 4 weeks prior to term, with platelets from HPA 1a-negative donors reserved for immediate transfusion if petechiae were present and/or if platelet count was less than 35 x 10(9)/L. Of the women screened, 2.1% were HPA 1a negative, and anti-HPA 1a was detected in 10.6% of these. One hundred seventy pregnancies were managed according to the intervention program, resulting in 161 HPA 1a-positive children. Of these, 55 had severe thrombocytopenia (< 50 x 10(9)/L), including 2 with intracranial hemorrhage (ICH). One woman with a twin pregnancy missed the follow-up and had one stillborn and one severely thrombocytopenic live child. In 15 previous prospective studies (136 814 women) there were 51 cases of severe NAIT (3 intrauterine deaths and 7 with ICH). Acknowledging the limitation of comparing with historic controls, implementation of our screening and intervention program seemed to reduce the number of cases of severe NAIT-related complications from 10 of 51 to 3 of 57.
Time-Resolved In Situ ATR-IR Observations of the Process of Sorption of Water into a Poly(2-methoxyethyl acrylate) Film (2007)

A process of water sorption into a biocompatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was investigated by time-resolved, in situ, attenuated total reflection infrared spectroscopy. Evidence for three different types of hydrated water in PMEA, that is, nonfreezing water, freezing bound water, and freezing water, were found. Each hydration structure was elucidated at the functional group level. Nonfreezing water, which never crystallizes, even at -100 degrees C, has a C=O...H-O type of hydrogen bonding interaction with the carbonyl group of PMEA. Freezing bound water, which crystallizes in a heating process below 0 degrees C, interacts with the methoxy moiety in the PMEA side chain terminal. Freezing water, which crystallizes approximately 0 degrees C, has bulk-water-like structure with an O-H...O-H hydrogen bonds network. It has been concluded from the present study that the methoxy moiety in the PMEA side chain terminal plays an important role for the excellent biocompatibility of PMEA.
Design of a Prospective Patient-Level Pooled Analysis of Two Parallel Trials of Empagliflozin in Patients with Established Heart Failure (2020)

The planned pooled analysis has an unusually high degree of statistical rigour that will allow it to address important questions that cannot be fully addressed by the individual trials.
Vegan Egg: A Future-Proof Food Ingredient? (2022)

Vegan eggs are designed with the aim to provide a healthier and more sustainable alternative to regular eggs. The major drivers of this industry are the increasing prevalence of egg allergies, awareness towards environmental sustainability, and the shift to vegan diets. This study intends to discuss, for the first time, the vegan egg market, including their formulation, nutritional aspects, and some applications (i.e., mayonnaise and bakery products). Recreating the complete functionality of eggs using plant-based ingredients is very challenging due to the complexity of eggs. Current, but scarce, research in this field is focused on making mixtures of plant-based ingredients to fit specific food formulations. Nutritionally, providing vegan eggs with similar or higher nutritional value to that of eggs can be of relevance to attract health-conscious consumers. Claims such as clean labels, natural, vegan, animal-free, gluten-free, and/or cholesterol-free can further boost the position of vegan eggs in the market in the coming year. At present, this market is still in its infancy stages, and clear regulations of labeling, safety, and risk assessment are deemed mandatory to organize the sector, and protect consumers.
Sulphonohydrazides and related compounds. Part VIII. Some aryl carboxylic acid sulphonohydrazides (1968)

In a search for new pest control agents the following sulphonohydrazides of aromatic acids have been prepared: 3-sulphonylhydrazino-, 2-methoxy-5-sulphonylhydrazino-, 4-methoxy-3-sulphonylhydrazino-, 2-hydroxy-5-sulphonylhydrazino-, 4-chloro-3-sulphonylhydrazino-, 4-chloro-3-sulphonylhydrazino-, 2-bromo-5-sulphonylhydrazino-, 2-methyl-5-sulphonylhydrazino-, 5-methyl-2-sulphonylhydrazino-, and 4-methyl-3-sulphonylhydrazino-benzoic acids, 4-sulphonylhydrazinocinnamic acid, and 4-sulphonylhydrazino-, and 2-chloro-4-sulphonylhydrazino-phenoxy acetic acids. The hydrazides have been converted into a number of derivatives (e.g., hydrazones, azides). It is suggested that the chlorosulphonation of aromatic carboxylic acids by chlorosulphuric acid involves a mixed anhydride type intermediate.
Field Validation of Acidizing Wormhole Models (2005)

Abstract In matrix acidizing of carbonate reservoirs, the generation of wormholes is a major key to success. Numerous papers have been written that describe the formation and propagation of such wormholes. Generally, these models have been based on sound chemistry and physics. Some of the models have been validated against laboratory experiments that are generally conducted in a linear geometry. However, in order to use the models in the design of matrix acid stimulation treatments, the models need to be validated under radial flow conditions that dominate field treatments. Radial flow, competing wormholes, permeability contrasts, and reservoir height are example parameters that cannot easily be validated in laboratory experiments. Scaling of the models to field conditions might be required. Two types of models have been written for aiding in treatment designs. One model, called a linear-type model, is fully consistent with the decades of linear flow tests conducted in the laboratory. The second model, called a symmetry model, is exceedingly difficult to validate in the laboratory. This paper evaluates both models against treating pressure responses from field treatments. A matrix treatment simulator was used that includes such effects as multiple formation layers with independent formation parameters and allows for modeling zonal coverage. The formation parameters include permeability, porosity, mineralogy, acid reactivity, skin damage, and permeability contrast. The well parameters include height of the layers, wellbore tubulars, friction pressures, etc. This simulator was an ideal framework for evaluating the two acidizing wormhole models. This paper demonstrates the key issues related to the interaction between the wormhole models and zonal coverage.
Limbal stem cell deficiency: Current management (2016)

Limbal stem cells (SCs) represent a key component of the corneal-conjunctival barrier and play a vital role in the regeneration and replacement of the corneal epithelium. These SCs are located in the basal region of the limbus, in the palisades of Vogt.Limbal SCs may be lost in a wide variety of conditions, the most common being chemical injury, thermal burns, Stevens-Johnson syndrome (SJS), and vernal keratoconjunctivitis. Limbal SC deficiency (LSCD) may result in a painful and blinding ocular surface disorder leading to epithelial defects and conjunctivilization of the cornea. The management of LSCD depends primarily on the laterality, extent of involvement of the eye, and the condition of the other eye. Amniotic membrane transplantation is an established technique used in acute stage to minimize the primary insult and prevent the development of LSCD. In cases of established LSCD, transplanted tissue may be derived from autologous or allogenic sources. Long-term results of cultured limbal epithelial stem cell transplant have demonstrated greater therapeutic success when compared to previous forms of treatment. Moreover, with the help of advances in microsurgical techniques and immunosuppressant drugs, clinical assessment of the outcome of ocular surface rehabilitative procedures grows increasingly optimistic. This article describes the role of SCs in corneal epithelial regeneration, as well as the etiology and clinical features of LSCD.
Magnetoresistance of bismuth nanowire arrays: A possible transition from one-dimensional to three-dimensional localization (1998)

This paper reports a series of magnetoresistance measurements made on arrays of bismuth nanowires with diameters ranging from 28\ifmmode\pm\else\textpm\fi{}3 to 70\ifmmode\pm\else\textpm\fi{}10 nm. The data were taken between 1.4 and 10 K in magnetic fields from 0 to 5 T. The magnetoresistance curves below 4.2 K show a steplike increase in magnetoresistance relative to the curves at 4.2 K, occurring at the field at which the magnetic length ${L}_{H}$ equals the wire diameter d. At low B fields where ${L}_{H}&gt;d,$ the electron wave function is confined by the wire diameter, while at high magnetic fields for which ${L}_{H}&lt;d,$ the carriers are in a bulklike environment. These results suggest that the steplike magnetoresistance is due to a transition between one-dimensional (1D) localization and 3D localization.
The Song (1977)

Soon I'll leave the little garret I've spent five years in, groomed and combed and grown used to, where I bedded my lover and housed my jubilation, relaxed, fretted, and pined, grew used to.A roommate once had an af ghan-hound with brown eyes like quicksand, and such long spindly legs it never could lie down right.I used to watch the poor beautiful creature circle, fold and unfold and fold its legs again, trying, for all the world, just to settle.
Homelessness, gender-based violence and social capital: The function of sexual alliances (2013)

Conventional depictions of homelessness fail to reflect the multitude of homeless experiences that are possible. It is imperative to challenge these understandings so that a variety of experiences are recognised and subsequently reflected in social policy and resource distribution. The application of a gendered lens is one possible way to challenge existing and limited representations of homelessness. Homelessness is not a gender neutral phenomenon.
Imaging, Intervention, and Workflow in Acute Ischemic Stroke: The Calgary Approach (2015)

Five recently published clinical trials showed dramatically higher rates of favorable functional outcome and a satisfying safety profile of endovascular treatment compared with the previous standard of care in acute ischemic stroke with proximal anterior circulation artery occlusion. Eligibility criteria within these trials varied by age, stroke severity, imaging, treatment-time window, and endovascular treatment devices. This focused review provides an overview of the trial results and explores the heterogeneity in imaging techniques, workflow, and endovascular techniques used in these trials and the consequent impact on practice. Using evidence from these trials and following a case from start to finish, this review recommends strategies that will help the appropriate patient undergo a fast, focused clinical evaluation, imaging, and intervention.
RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment (2017)

After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis. To develop therapeutic strategies targeting RBPs, RNA interference-based oligonucleotides or small molecule inhibitors have been screened based on reduced RBP-RNA interaction and changed level of target RNAs. Identification of binding RNAs with high-throughput techniques and integral analysis of multiple datasets will help us develop new therapeutic drugs or prognostic biomarkers for human cancers.
Texture-based prostate cancer classification on MRI: how does inter-class size mismatch affect measured system performance? (2019)

Multi-parametric MRI (mp-MRI) has shown to be useful in contemporary prostate biopsy procedures. Unfortunately, mp-MRI is relatively complex to interpret and suffers from inter-observer variability in lesion localization and grading. Computer-aided diagnosis (CAD) systems have been developed as a potential solution and have been shown to boost diagnostic accuracy. We measured the accuracy of a CAD model using a systematic sampling algorithm to remove any spatial bias present in our input. We trained four classifiers with 1–10 features chosen by forward feature selection for each and reported the system with the highest AUC in both the peripheral zone and central gland. Furthermore, we investigated the effect on system performance by varying the minimum tumour size threshold and by varying the average difference in area between malignant and healthy tissue samples. The CAD model was able to classify malignant vs. benign tissue with accuracies competitive with those reported in the literature. Eroding healthy tissue ROIs positively biased the system’s performance for the PZ, but no such trend was found in the CG. Once fully validated, this system has the potential to imp
THE CAUSE OF PHYSIOLOGIC BASAL TEMPERATURE CHANGES IN WOMEN* (1948)

THE clinical application of basal temperature changes in the study of ovarian function has met with wide acceptance since the publications of Tompkins (1), Davis (2) and others (3, 4, 5). This simple physiologic phenomenon has provided a much-needed tool for the interpretation of normal and abnormal ovarian activity. The mechanism for these temperature fluctuations has not been elucidated. The following observations were carried out in an attempt to throw additional light on this subject. In the past three years well over 1000 temperature graphs have accumulated in the study of sterility and other endocrine disorders, as well as in a large group of normal individuals who were used as controls. These graphs have been prepared by the patients themselves after careful instructions on how to keep a basal temperature record. Oral temperatures have been used throughout, since it has been demonstrated that the pattern is similar to rectal temperatures and that the latter provide no greater degree of accuracy. Most patients have obtained readings over a period of three or four months but many have kept a continuous graph for a year or longer.
Corrigendum: New Triblock Copolymer Templates, PEO‐PB‐PEO, for the Synthesis of Titania Films with Controlled Mesopore Size, Wall Thickness, and Bimodal Porosity (2012)

of Figure
Neural Image Enhancement Allows Honeybees to See at Night (1997)

The optical design of most insect apposition compound eyes should restrict activity to daylight because at night the tiny lenses of the isolated ommatidia cannot collect sufficient light. However, several bee species have adopted nocturnal activity, taking advantage of the benefits of night foraging. By measuring behavioural visual performance in honeybees, we show that insects can possess better spatial resolution in dim light than the optics and physiology of their apposition eyes suggest, implying the presence of higher neural mechanisms which enhance vision at night. Theoretical calculations reveal that honeybees improve light capture at night by neurally summing photons in space and time. Even though summation compromises both spatial and temporal resolution, the improved photon capture enhances vision sufficiently for bees to discriminate coarse images in moonlight. This explains how bees and many other insects can adopt a nocturnal life style despite having an eye design typical of a day-active insect.
ChemInform Abstract: ADSORPTION VON STICKSTOFFOXID AN ZEOLITHE VOM Y‐TYP, EINE TIEFTEMPERATUR‐INFRAROTUNTERSUCHUNG (1972)

Abstract NO wird adsorbiert an Cab‐O‐Sil, HY, dekationiertem Y‐, NaY‐ und CaY‐Zeolith bei ‐190, ‐150, ‐13O und ‐73°C. Aus den IR‐Spektren geht hervor, daß drei unterschiedliche Adsorptionsspezies gebildet werden: Adsorbiertes N202, adsorbiertes NO und Produkte aus NO‐Disproportionierungsreaktionen.
Front Cover: Tetrazine‐Triggered Bioorthogonal Cleavage of trans‐Cyclooctene‐Caged Phenols Using a Minimal Self‐Immolative Linker Strategy (ChemBioChem 20/2022) (2022)

Bioorthogonal prodrug activation: The cover feature illustrates the release of a phenolic drug triggered by the reaction of a trans-cyclooctene (TCO) conjugate with a tetrazine molecule (Tz). Key to the structural design is the incorporation of a self-immolative linker (SIL) that ‘dissolves’ upon TCO/Tz click, enabling the development of bis(carbamate)-linked conjugates with substantially improved stability under physiological conditions. Applying this strategy, we demonstrate the bioorthogonal cleavage of a TCO-SIL-caged prodrug via in situ reaction with Tz. Thereby, we achieved controlled release of an antimitotic drug that induces depolymerization of microtubules, leading to a >200-fold ‘turn-on’ in cytotoxicity. More information can be found in the Research Article by H. Mikula et al.
Redox-switched molecular aggregates: the first example of vesicle formation from hydrophobic ferrocene derivatives (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRedox-switched molecular aggregates: the first example of vesicle formation from hydrophobic ferrocene derivativesJulio C. Medina, Isabelle Gay, Zhihong Chen, Luis Echegoyen, and George W. GokelCite this: J. Am. Chem. Soc. 1991, 113, 1, 365–366Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ja00001a056https://doi.org/10.1021/ja00001a056research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A fatal endocarditis case due to an emerging bacterium: Moraxella nonliquefaciens (2017)

<i>Moraxella nonliquefaciens</i> is a Gram-negative coccobacillus considered as a commensal organism from the upper respiratory tract, with low pathogenic potential. The phenotypical conventional identification is difficult and the matrix-assisted laser desorption/ionization time-of-flight technology has increased the resolution of identification of this bacterium. We report a fatal case of endocarditis due to <i>M. nonliquefaciens</i> whose identification was confirmed by 16S rRNA, and we review the literature on this pathogen in endocarditis.
Strukturisomere Palladiumkomplexe des Typs C5H5Pd(2‐RC3H4)L – Ein Beispiel für simultane π/σ‐ und σ/π‐Umlagerung von zwei organischen Liganden (1979)

Interessante Strukturverhältnisse bei Palladiumkomplexen wurden am Beispiel von ( 1 ) beobachtet: ( 1a ) geht in Lösung einer sehr rasche metallotrope Umlagerung ein, d. h. es. hat eine fluktuierende Struktur, während sich beim homologen ( 1b ) zwei Bindungsisomere ineinander umlagern. magnified image
Elastic wave propagation software in structural health monitoring (2009)

W pracy omowiono program do analizy propagacji fal sprezytsych w lementach konstrukcji z uszkodzeniami, oraz omowiono mozliwości jego wykorzystania do monitorowania stanu konstrukcji.
Evidence for Light-Induced Hole Polarons inLiNbO3 (2005)

Transient light-induced absorption in LiNbO3 is observed in the blue-green spectral range after pulsed illumination with 532 nm. Its buildup and decay in Fe-doped LiNbO3 is satisfactorily described by a sum of two stretched exponential functions. For undoped LiNbO3, however, only one stretched exponential decay is observed. These experimental results are explained by the formation of both small Nb(Li)4+ electron polarons and O- hole polarons. The mechanism is discussed on the basis of a proposed band scheme.
Design of a Ballistically-Launched Foldable Multirotor (2019)

The operation of multirotors in crowded environments requires a highly reliable takeoff method, as failures during takeoff can damage more valuable assets nearby. The addition of a ballistic launch system imposes a deterministic path for the multirotor to prevent collisions with its environment, as well as increases the multirotor's range of operation and allows deployment from an unsteady platform. In addition, outfitting planetary rovers or entry vehicles with such deployable multirotors has the potential to greatly extend the data collection capabilities of a mission. A proof-of-concept multirotor aircraft has been developed, capable of transitioning from a ballistic launch configuration to a fully controllable flight configuration in midair after launch. The transition is accomplished via passive unfolding of the multirotor arms, triggered by a nichrome burn wire release mechanism. The design is 3D printable, launches from a three-inch diameter barrel, and has sufficient thrust to carry a significant payload. The system has been fabricated and field tested from a moving vehicle up to 50mph to successfully demonstrate the feasibility of the concept and experimentally validate the design's aerodynamic stability and deployment reliability. SUPPLEMENTARY MATERIAL Videos of the experiments: https://youtu.be/sQuKJfllyRM.
Fully iterative fast array for binary multiplication and addition (1969)

A fast combinational circuit is described which can be used both as a multiplier and as an adder, either separately or together, giving a parallel binary output. The structure, which is completely iterative in terms of both cell logic and cell-interconnection pattern, is advantageous in large-scale integration.