gebhart/patrepeval huggingface dataset:
Scalable Load Distribution and Load Balancing for Dynamic Parallel Programs (1999)

This paper reports design and preliminary evaluation of an integrated load distribution-load balancing algorithm which was targeted to be both efficient and scalable for dynamically structured computations. The computation is represented as a dynamic hierarchical dependence graph. Each node of the graph may be a subgraph or a computation and the number of instances of each node is dynamically determined at runtime. The algorithm combines an initial partitioning of the graph with application of randomized work stealing on the basis of subgraphs to refine imbalances in the initial partitioning and balance the additional computational work generated by runtime instantiation of subgraphs and nodes. Dynamic computations are modeled by an artificial program (k-nary) where the amount of parallelism is parameterized. Experiments on IBM SP2s suggest that the load balancing algorithm is efficient and scalable for parallelism up to 10,000 parallel threads for closely coupled distributed memory architectures.
A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer (2015)

In this phase I study, refametinib plus sorafenib was well tolerated, with good oral absorption, near-dose proportionality, and target inhibition in a range of tumor types. Clin Cancer Res; 22(10); 2368-76. ©2015 AACR.
Single-inductor dual-input dual-output switching converter for integrated battery charging and power regulation (2003)

A single-inductor dual-input dual-output switching converter is presented. This converter can be used in a battery power management system for portable equipment and requires only 5 integrated power devices and 1 external inductor for battery-charging, power multiplexing and voltage regulation. It is designed using a 0.6 /spl mu/m CMOS process. Simulation results demonstrated functionality and high efficiency of the converter.
Half-of-Sites Binding of Orotidine 5‘-Phosphate and α-d-5-Phosphorylribose 1-Diphosphate to Orotate Phosphoribosyltransferase from Saccharomyces cerevisiae Supports a Novel Variant of the Theorell−Chance Mechanism with Alternating Site Catalysis (2006)

A ping-pong bi-bi kinetic mechanism ascribed to yeast orotate phosphoribosyltransferase (OPRTase) [Victor, J., Greenberg, L. B., and Sloan, D. L. (1979) J. Biol. Chem. 254, 2647-2655] has been shown to be inoperative [Witte, J. F., Tsou, R., and McClard, R. W. (1999) Arch. Biochem. Biophys. 361, 106-112]. Radiolabeled orotidine 5'-phosphate (OMP), generated in situ from [7-(14)C]-orotate and alpha-d-5-phoshorylribose 1-diphosphate (PRPP), binds tightly enough to OPRTase (a dimer composed of identical subunits) that the complex survives gel-filtration chromatography. When a sample of OMP.OPRTase is extensively dialyzed, a 1:1 (per OPRTase dimer) complex is detected by (31)P NMR. Titration of the apoenzyme with OMP yields a (31)P NMR spectrum with peaks for both free and enzyme-bound OMP when OMP is in excess; the complex maintains an OMP/enzyme ratio of 1:1 even when OMP is in substantial excess. A red shift in the UV spectrum of the OMP.OPRTase complex was exploited to measure K(d(OMP)) = 0.84 muM and to verify the 1:1 binding stoichiometry. PRPP forms a Mg(2+)-dependent 1:1 complex with the enzyme as observed by (31)P NMR. Isothermal titration calorimetry (ITC) experiments revealed 1:1 stoichiometries for both OMP and Mg(2+)-PRPP with OPRTase yielding K(d) values of 0.68 and 10 microM, respectively. The binding of either 1 equiv of OMP or PRPP is mutually exclusive. ITC experiments demonstrate that the binding of OMP is largely driven by increased entropy, suggesting substantial distal disordering of the protein. Analytical gel-filtration chromatography confirms that the OMP.OPRTase complex involves the dimeric form of enzyme. The off rate for release of OMP, determined by magnetization inversion transfer, was determined to be 27 s(-)(1). This off rate is somewhat less than the k(cat) in the biosynthetic direction (about 39 s(-)(1)); thus, the release of OMP from OMP.OPRTase may not be kinetically relevant to the steady-state reaction cycle. The body of available data can be explained in terms of alternating site catalysis with either a classical Theorell-Chance mechanism or, far more likely, a novel "double Theorell-Chance" mechanism unique to alternating site catalysis, leading us to propose co-temporal binding of orotate and the release of diphosphate as well as the binding of PRPP and the release of OMP that occur via ternary complexes in alternating site fashion across the two highly cooperative subunits of the enzyme. This novel "double Theorell-Chance" mechanism yields a steady-state rate equation indistinguishable in form from the observed classical ping-pong bi-bi kinetics.
Non-Terrestrial Networks in 5G & Beyond: A Survey (2020)

Fifth-generation (5G) telecommunication systems are expected to meet the world market demands of accessing and delivering services anywhere and anytime. The Non-Terrestrial Network (NTN) systems are able to satisfy the requests of anywhere and anytime connections by offering wide-area coverage and ensuring service availability, continuity, and scalability. In this work, we review the 3GPP NTN features and their potential for satisfying the user expectations in 5G & beyond networks. The state of the art, current 3GPP research activities, and open issues are summarized to highlight the importance of NTN over the wireless communication landscape. Future research directions are also identified to assess the role of NTN in 5G and beyond systems.
Solvent Dependent Dehydrating Condensation of Benzylsulfonyl Acetic Acids (2004)

Abstract Convenient and simple synthesis of β‐keto benzylsulfones, isothiochromanone‐2,2‐dioxides was carried out by dehydrating condensation of benzylsulfonyl acetic acids using phosphorous pentoxide in aromatic solvents benzene and halobenzenes. Depending on the solvents, the products formed were predominantly either β‐keto benzylsulfones or isothiochromanone‐2,2‐dioxides.
ChemInform Abstract: STRUCTURE DETERMINATION AND SYNTHESIS OF DISACCHARIDE FRAGMENTS B‐A OF MITHRAMYCIN (1983)

Abstract Durch 1 H‐NMR‐Vergleich von Mithramycin‐acetat (Ib) mit dem synthetisierten 1 ‐ 3‐verknüpften (VIIb) bzw. mit dem ebenfalls synthetisierten 1 ‐ 4‐verknüpften Disaccharidacetat (VIIIb) [der Vergleich von Mithramycin (Ia) mit den freien Disacchariden (VIId) bzw. (VIIId) ist nicht geeignet] kann jetzt die bei der Strukturermittlung von (Ia) noch offene Frage der Verknüpfung der Zuckerbausteine B‐A ge‐ 164 klärt werden.
Accès aux tests génétiques en oncologie (2022)

L’accès aux tests génétiques dans le domaine de la cancérologie prend de plus en plus d’importance au fur et à mesure des découvertes de la recherche fondamentale, translationnelle et clinique. Il a ainsi été possible de démontrer que des cancers fréquents dont le diagnostic reposait essentiellement sur la localisation anatomique et l’examen anatomopathologique étaient en fait une collection de maladies plus rares définies par des altérations moléculaires. Ces altérations de type mutations, amplification, ou fusion nécessitent le recours à des outils sophistiqués tels que le next generation sequencing (NGS). Au-delà d’une caractérisation meilleure des maladies, cette analyse moléculaire permet la définition de cibles accessibles à des médicaments spécifiques ce qui constitue la base de la médecine personnalisée en cancérologie. Même si l’évaluation clinique des certaines molécules n’a pas toujours été couronnée de succès, l’amélioration de la survie des patients ayant un cancer du poumon par exemple confirme tout le bien-fondé de ce concept. Le problème est donc maintenant l’accès à ces tests qui ne sont pas pris en charge par des mécanismes précis efficaces comme le sont les molécules onéreuses ou les dispositifs implantables ce qui aboutit à des inégalités de prise en charge des cancers sur le territoire français posant un véritable problème éthique.
Measuring Interest of Human Dyadic Interactions (2009)

In this paper, we argue that only using behavioural motion information, we are able to predict the interest of observers when looking at face-to-face interactions. We propose a set of movement-related features from body, face, and mouth activity in order to define a set of higher level interaction features, such as stress, activity, speaking engagement, and corporal engagement. Error-Correcting Output Codes framework with an Adaboost base classifier is used to learn to rank the perceived observer's interest in face-to-face interactions. The automatic system shows good correlation between the automatic categorization results and the manual ranking made by the observers. In particular, the learning system shows that stress features have a high predictive power for ranking interest of observers when looking at of face-to-face interactions.
Prevention of vesicoureteral reflux in neonatal patients with intravesical ureterocele using holmium-laser. (2023)

Laser Reflux Prevention, Ureterocele.
Analysis of an integrated optical coherent receiver with optical state of polarization control (1991)

Abstract An integrated optical coherent receiver with continuous state of polarization control is proposed and analyzed. The receiver consists of an integrated optical polarization rotator, a state of polarization detector and a balanced mixer receiver. Continuous state of polarization control can be achieved by using two polarization rotators in series and feeding the polarization rotator outputs into the state of polarization detector whose subsequent output is used to control the voltage settings on the polarization rotator. For the general case, the polarization rotator is comprised of two phase shifters and a TE – TM mode converter. The state of polarization detector stage consists of a δβ directional coupler mode splitter. A novel fabrication technique for achieving efficient polarization splitting is discussed. A balanced mixer receiver is implemented using a passive directional coupler with 50/50 power splitting. The need for a passive device is demonstrated and a method for achieving accurate power splitting ratios using the proton exchange fabrication technique is discussed and experimentally demonstrated. An analysis of the performance of such a system including the balanced mixer receiver is carried out to identify the critical areas of fabrication. Discussion is also given to the function and characteristics of the electronic control loop.
Compact USB-powered mobile ELISA-based pathogen detection: design and implementation challenges (2011)

Physical Optics Corporation (POC) presents a novel Mobile ELISA-based Pathogen Detection system that is based on a disposable microfluidic chip for multiple-threat detection and a highly sensitive portable microfluidic fluorescence measurement unit that also controls the flow of samples and reagents through the microfluidic channels of the chip. The fluorescence detection subsystem is composed of a commercial 635-nm diode laser, an avalanche photodiode (APD) that measures fluorescence, and three filtering mirrors that provide more than 100 dB of excitation line suppression in the signal detection channel. Special techniques to suppress the fluorescence and scattering background allow optimizing the dynamic range for a compact package. Concentrations below 100 ng/mL can be reliably identified. The entire instrument is powered using a USB port of a notebook PC and operates as a plug-and-play human-interface device, resulting in a truly peripheral biosensor. The operation of the system is fully automated, with minimal user intervention through the detection process. The resolved challenges of the design and implementation are presented in detail in this publication.
Do Phosphatidylinositides Modulate Vertebrate Phototransduction? (2000)

Mammalian rod cyclic nucleotide gated (CNG) channels (i.e., alpha plus beta subunits) are strongly inhibited by phosphatidylinositol 4, 5-bisphosphate (PIP(2)) when they are expressed in Xenopus oocytes and studied in giant membrane patches. Cytoplasmic Mg-ATP inhibits CNG currents similarly, and monoclonal antibodies to PIP(2) reverse the effect and hyperactivate currents. When alpha subunits are expressed alone, PIP(2) inhibition is less strong; olfactory CNG channels are not inhibited. In giant patches from rod outer segments, inhibition by PIP(2) is intermediate. Other anionic lipids (e.g., phosphatidyl serine and phosphatidic acid), a phosphatidylinositol-specific phospholipase C, and full-length diacylglycerol have stimulatory effects. Although ATP also potently inhibits cGMP-activated currents in rod patches, the following findings indicate that ATP is used to transphosphorylate GMP, generated from cGMP, to GTP. First, a phosphodiesterase (PDE) inhibitor, Zaprinast, blocks inhibition by ATP. Second, inhibition can be rapidly reversed by exogenous regulator of G-protein signaling 9, suggesting G-protein activation by ATP. Third, the reversal of ATP effects is greatly slowed when cyclic inosine 5'-monophosphate is used to activate currents, as expected for slow inosine 5' triphosphate hydrolysis by G-proteins. Still, other results remain suggestive of regulatory roles for PIP(2). First, the cGMP concentration producing half-maximal CNG channel activity (K(1/2)) is decreased by PIP(2) antibody in the presence of PDE inhibitors. Second, the activation of PDE activity by several nucleotides, monitored electrophysiologically and biochemically, is reversed by PIP(2) antibody. Third, exogenous PIP(2) can enhance PDE activation by nucleotides.
Structural Determinants of Opioid Activity in Derivatives of 14-Aminomorphinones:  Effect of Substitution in the Aromatic Ring of Cinnamoylaminomorphinones and Codeinones (2006)

In recent years there has been substantial interest in the 14-aminodihydromorphinone derivatives methoclocinnamox (MC-CAM) and clocinnamox (C-CAM). To investigate the importance of the cinnamoyl ring substituent, a series of analogues have been prepared with chloro, methyl, and nitro substituents in the 2' and 4' positions. Despite some discrepancies between the in vitro and in vivo data, a clear SAR could be observed where the 2'-chloro and 2'-methyl ligands consistently displayed higher efficacy than their 4'-substituted analogues. The new series also followed the well-established SAR that 17-methyl ligands have greater efficacy at the mu opioid receptor than their 17-cyclopropylmethyl counterparts.
Stochastic Assessment of the Economic Impact of Streptococcus suis-Associated Disease in German, Dutch and Spanish Swine Farms (2021)

The economic assessment of animal diseases is essential for decision-making, including the allocation of resources for disease control. However, that assessment is usually hampered by the lack of reliable data on disease incidence, or treatment and control measures, and that is particularly true for swine production diseases, such as infections caused by <i>Streptococcus suis</i>. Therefore, we deployed a questionnaire survey of clinical swine veterinarians to obtain the input data needed for a stochastic model to calculate the costs caused by <i>S. suis</i>, which was implemented in three of the main swine producing countries in Europe: Germany, the Netherlands and Spain. <i>S. suis</i>-associated disease is endemic in those countries in all production phases, though nursery was the phase most severely impacted. In affected nursery units, between 3.3 and 4.0% of pigs had <i>S. suis</i>-associated disease and the mortalities ranged from 0.5 to 0.9%. In Germany, the average cost of <i>S. suis</i> per pig (summed across all production phases) was 1.30 euros (90% CI: 0.53-2.28), in the Netherlands 0.96 euros (90% CI: 0.27-1.54), and in Spain 0.60 euros (90% CI: 0.29-0.96). In Germany, that cost was essentially influenced by the expenditure in early metaphylaxis in nursery and in autogenous vaccines in sows and nursery pigs; in the Netherlands, by expenditure on autogenous vaccines in sows and nursery pigs; and in Spain, by the expenditures in early metaphylaxis and to a lesser extent by the mortality in nursery pigs. Therefore, the differences in costs between countries can be explained to a great extent by the measures to control <i>S. suis</i> implemented in each country. In Spain and in Germany, use of antimicrobials, predominantly beta-lactams, is still crucial for the control of the disease.
Rapid communication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus2 (1994)

Journal Article Rapid communication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus Get access D. A. Vaske, D. A. Vaske 6Department of Animal Science, Iowa State University, Ames 50011-3150 Search for other works by this author on: Oxford Academic PubMed Google Scholar M. K. Ruohonen-Lehto, M. K. Ruohonen-Lehto 6Department of Animal Science, Iowa State University, Ames 50011-3150 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. G. Larson, R. G. Larson 6Department of Animal Science, Iowa State University, Ames 50011-3150 Search for other works by this author on: Oxford Academic PubMed Google Scholar C. M. Warner, C. M. Warner 6Department of Animal Science, Iowa State University, Ames 50011-3150 Search for other works by this author on: Oxford Academic PubMed Google Scholar M. F. Rothschild M. F. Rothschild 6Department of Animal Science, Iowa State University, Ames 50011-3150 5To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Animal Science, Volume 72, Issue 1, January 1994, Page 255, https://doi.org/10.2527/1994.721255x Published: 01 January 1994 Article history Received: 01 September 1993 Accepted: 01 October 1993 Published: 01 January 1994
Agrochemicals From Natural Products (1994)

Insecticides pyrethroids juvenile hormones avermectins herbicides and plant growth regulators fungicides and bactericides animal health products rodenticides biological control agents.
Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis (2019)

PAR assessed by RRT nurses can be a useful tool for assessing short-term patient prognosis in the RRT setting.
Supplementary Figure from Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data (2023)

Supplementary Figure from Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Ca2+-sensing receptors in intestinal epithelium (1997)

Expression of Ca2+-sensing receptors (CaR) was demonstrated in several human intestinal epithelial cell lines (T84, HT-29, and Caco-2) and in rat intestinal epithelium by both reverse transcriptase-polymerase chain reaction (PCR) and Northern blotting of RNA. Restriction patterns of the PCR products were of the sizes predicted by the human and rat sequences. CaR agonists (Ca2+, poly-L-arginine, protamine) mediated an increase in intracellular Ca2+ in HT-29-18-C1 cells (monitored by changes in fura 2 fluorescence), which was dependent on release from thapsigargin-sensitive stores. U-73122, an inhibitor of phosphatidylinositol-phospholipase C, eliminated the CaR agonist-mediated rise in intracellular Ca2+, whereas its inactive analog, U-73343, had no effect. Pertussis toxin pretreatment had no effect on CaR agonist-mediated modulation of intracellular Ca2+. Taken together, these studies demonstrate that CaR are expressed in intestinal epithelial cells and couple to mobilization of intracellular Ca2+. The presence of CaR in intestinal epithelial cells presents a new locus for investigations into the role(s) of extracellular Ca2+ in modulating intestinal epithelial cell differentiation and transepithelial Ca2+ transport.
The hydrogen bond energies of the bihalide ions XHX− and YHX− (1985)

Experimental measurements of the gas phase ion equilibria X − + HX = XHX − , X − (HX) n−1 + HX = X − (HX) n , and X − + HY = XHY where X, Y = Cl, Br, I, with a high pressure mass spectrometer, combined with the recent determination of F − + HF = FHF − by Larson and McMahon, provide a very complete set of hydrogen bond dissociation enthalpies and free energies for the hydrogen bihalide ions. The bond energy trends in the different XHX − and XHY − are discussed. The data can be used also for the evaluation of lattice energies of salts containing the bihalide ions and for determinations of the solvation energies of these ions.
Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögrenʼs syndrome (1989)

Scripps Clinic and Research Foundation, La Jolla, California, USA Current Opinion in Rheumatology 1989, 1:376-381
Continuous Intravenous Administration of Ketorolac Reduces Pain and Morphine Consumption After Total Hip or Knee Arthroplasty (1995)

The purpose of this study was to determine the analgesic efficacy, opioid-sparing effect, and tolerability of ketorolac administered as an intravenous (IV) bolus followed by a continuous infusion after total hip or knee arthroplasty. After general anesthesia, patients received either placebo or ketorolac 30 mg IV as a bolus over 15-30 s followed by a continuous IV infusion of ketorolac 5 mg/h for 24 h. All patients received patient-controlled IV morphine with no background infusion. Patients were assessed at 2, 4, 6, and 24 postoperatively with respect to analgesia, morphine consumption, side effects, and blood loss. Patients receiving ketorolac reported were less sedated and required fewer antiemetics. There was no difference in blood loss. Patients receiving ketorolac reported better analgesia and used less morphine (35% for hips and 44% for knees) than those receiving placebo. (Anesth Analg 1995;81:1175-80)
CoCoA: conditional correlation models with association size (2022)

Many scientific questions can be formulated as hypotheses about conditional correlations. For instance, in tests of cognitive and physical performance, the trade-off between speed and accuracy motivates study of the two variables together. A natural question is whether speed-accuracy coupling depends on other variables, such as sustained attention. Classical regression techniques, which posit models in terms of covariates and outcomes, are insufficient to investigate the effect of a third variable on the symmetric relationship between speed and accuracy. In response, we propose a conditional correlation model with association size, a likelihood-based statistical framework to estimate the conditional correlation between speed and accuracy as a function of additional variables. We propose novel measures of the association size, which are analogous to effect sizes on the correlation scale while adjusting for confound variables. In simulation studies, we compare likelihood-based estimators of conditional correlation to semiparametric estimators adapted from genomic studies and find that the former achieves lower bias and variance under both ideal settings and model assumption misspecification. Using neurocognitive data from the Philadelphia Neurodevelopmental Cohort, we demonstrate that greater sustained attention is associated with stronger speed-accuracy coupling in a complex reasoning task while controlling for age. By highlighting conditional correlations as the outcome of interest, our model provides complementary insights to traditional regression modeling and partitioned correlation analyses.