gebhart/patrepeval huggingface dataset:
Microelectromechanical-System-Based Design of a High-Finesse Fiber Cavity Integrated with an Ion Trap (2019)

The ion-cavity quantum interface is an important building block for tomorrow's quantum networks, but miniaturizing such devices remains an outstanding challenge. This study introduces and characterizes an on-chip design that uses microelectromechanical-systems (MEMS) technology to integrate a fiber-based optical resonator with an ion trap. Simulations show that the device's performance is expected to be similar to that of much larger existing systems, and that it is compatible with strong ion-cavity coupling. A MEMS approach thus offers a promising route to scalable quantum networks based on miniaturized, fast, high-fidelity interfaces.
The role of the l‐arginine‐nitric oxide pathway in relaxation of the opossum lower oesophageal sphincter (1991)

1. The role of the L-arginine-nitric oxide pathway in lower oesophageal sphincter (LOS) relaxation and oesophageal peristalsis was investigated. 2. Twenty four adult opossums were anaesthetized and the right vagus nerve was isolated in the neck and sectioned. Electrical stimulation, applied to the peripheral end of the nerve, resulted in a frequency-dependent relaxation of the LOS, and peristaltic and non-peristaltic contractions in the oesophageal body. 3. N omega-nitro-L-arginine (L-NNA, 10(-8)-10(-5) mol kg-1), an inhibitor of the L-arginine-nitric oxide pathway, inhibited LOS relaxation in a dose-dependent manner, but did not affect resting LOS pressure. At the highest dose of L-NNA no relaxation of the LOS was elicited in response to vagal stimulation. The effect of L-NNA, (10(-5) mol kg-1) was fully reversed by infusion of 10(-4) mol kg-1 L-arginine. Peristaltic velocity and amplitude of contractions in the oesophageal body were unaffected by L-NNA. 4. Infusion of sodium nitroprusside reduced LOS pressure to zero, and the drug was equally potent in control animals (-log ED50:8.1 +/- 0.2 mol kg-1) and in animals pretreated with L-NNA (-log ED50:8.2 +/- 0.3 mol kg-1). This suggests that the effect of L-NNA was not directly on guanylate cyclase. 5. A significant elevation of blood pressure was recorded after administration of L-NNA (10(-5) mol kg-1). 6. It is suggested that the L-arginine-nitric oxide pathway plays an important functional role for relaxation of the LOS, but not for oesophageal peristalsis. Whether the active substance is nitric oxide or a related nitroso-compound remains to be settled.
A new structure-from-motion ambiguity (2003)

This paper demonstrates the existence of a generic approximate ambiguity in Euclidean structure from motion (SFM) which applies to scenes with large depth variation. In projective SFM the ambiguity is absent, but the maximum-likelihood reconstruction is more likely to have occasional very large errors. The analysis gives a semi-quantitative characterization of the least-squares error surface over a domain complementary to that analyzed by Jepson/Heeger/Maybank.
Fast Fourier Transform Algorithm For Two-Dimensional Array Of Processors (1988)

The paper discusses mapping of a Fast Fourier Transform (FFT), Haar Transform and Hadamard Transform algorithms onto a small, two-dimensional, mesh-connected array of processors. The FFT algorithm is an in-place, decimation in frequency, Cooley-Tuckey algorithm in radix 2 and radix 4 versions applied to multidimensional, complex inputs. The data flow of the algorithms has been implemented on the array using an efficient, regular data transfer pattern, uniform for all the algorithms. The inputs and constants used in the algorithms are prestored in the local memories of the processors. The mapping makes it possible to reduce significantly the number of memory locations needed for the constants. A partitioning scheme has been developed for the algorithms which allows us to execute them with inputs of arbitrary size on a small processor array. Also an algorithm has been proposed for the processor array, which efficiently unscrambles the bit reversed output of the FFT algorithm. The processors of the array have East, West, North, South interconnections with their nearest neighbors. The local memory of the processors is small, on the order of hundreds of locations. The processors are controlled in Single Instruction Multiple Data Stream (SIMD) mode and can be selectively disabled using simple masks, consisting of combinations of rows or columns.
MIGRASI SISTEM INFORMASI FARMASI DI RS TELOGOREJODARI MS VISUAL FOXPRO KE PHPDENGAN BASIS DATA MS SQL (2011)

Sistem Informasi Farmasi dalam sebuah rumah sakit mutlak diperlukan untuk mendukung
proses pelayanan terhadap pasien. Rumah sakit yang berskala besar memiliki lebih dari satu pusat
pelayanan farmasi, sehingga diperlukan sebuah sistem yang mampu menyimpan dan memproses semua
data-data transaksi untuk proses selanjutnya, seperti pembuatan laporan stock.
Basis data MS Visual Foxpro yang digunakan di RS Telogorejo sebagai Sistem Informasi
Farmasi tidak lagi mampu melayani proses transaksi karena begitu besarnya data dan banyaknya
transaksi, sehingga menghasilkan proses perhitungan yang salah. Dengan melakukan proses migrasi data
dari MS Visual Foxpro ke MS SQL akan didapatkan data yang akurat.
Aplikasi dengan program MS Visual Foxpro atau file sharing dalam proses penyimpanan data
harus melakukan locking file, membuat aplikasi lain tidak dapat mengakses sebuah file secara bersamaan.
Perubahan sistem aplikasi dari file sharing ke bentuk client-server dapat menghilangkan proses locking
file, yang menjadikan semua aplikasi dapat berjalan secara bersamaan
Homologous recombination at the border: Insertion-deletions and the trapping of foreign DNA in Streptococcus pneumoniae (2002)

Integration of foreign DNA was observed in the Gram-positive human pathogen Streptococcus pneumoniae (pneumococcus) after transformation with DNA from a recombinant Escherichia coli bacteriophage lamda carrying a pneumococcal insert. Segments of lamda DNA replaced chromosomal sequences adjacent to the region homologous with the pneumococcal insert, whence the name insertion-deletion. Here we report that a pneumococcal insert was absolutely required for insertion-deletion formation, but could be as short as 153 bp; that the sizes of foreign DNA insertions (289-2,474 bp) and concomitant chromosomal deletions (45-1,485 bp) were not obviously correlated; that novel joints clustered preferentially within segments of high GC content; and that the crossovers in 29 independent novel joints were located 1 bp from the border or within short (3-10 nt long) stretches of identity (microhomology) between resident and foreign DNA. The data are consistent with a model in which the insert serving as a homologous recombination anchor favors interaction and subsequent illegitimate recombination events at microhomologies between foreign and resident sequences. The potential of homology- directed illegitimate recombination for genome evolution was illustrated by the trapping of functional heterologous genes.
Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the “French paradox” (2002)

The mortality rate from coronary artery disease (CAD) in France is approximately 50% compared to other European countries and the United States ("French paradox"). Epidemiological studies indicate an inverse relationship between moderate wine consumption and CAD mortality. Here, we demonstrate that preincubation of vascular smooth muscle cells (VSMCs) with red wine, but not white wine, inhibits ligand binding and the subsequent tyrosine phosphorylation of the platelet-derived growth factor beta receptor (betaPDGFR), which plays a critical role in the pathogenesis of atherosclerosis. As a consequence, red wine abrogates the ligand-induced recruitment of betaPDGFR-associated signaling molecules (RasGAP, SHP-2, PI3K, PLCgamma), PDGF-dependent downstream events such as Erk activation and induction of immediate early genes, and VSMC proliferation and migration. Wine analysis revealed flavonoids of the catechin family as major constituents of red wine, and these were identified as potent inhibitors of betaPDGFR signaling. Importantly, the concentrations of red wine/catechins shown to inhibit the PDGFR in vitro correlate with the serum levels after red wine consumption in humans. We conclude that nonalcoholic constituents of red wine, which accumulate during the "mash fermentation," inhibit betaPDGFR activation and PDGF-dependent cellular responses in VSMCs. Therefore, catechin-mediated inhibition of betaPDGFR signaling offers a molecular explanation for the "French paradox."
Spotlight on EPDM Elastomers (1992)

Abstract Etylene-propylene diene monomer (EPDM) rubbers have become widely recognized as an important class of elastomers in an enormous variety of consumer-type products. Typical examples where this material is used include seals around automotive doors, trunks, and windows; hosing materials used in automotive radiator applications, ply-roofing material in construction; specialty sealing gaskets and O-rings for various consumer products; electrical sheathing; plastic blends such as automotive bumpers; oil modifiers; and many others. EPDM is a unique material, having almost exceptional environmental resistance properties and capable of bcing extended to high levels of filler loading, while maintaining good physical as well as elasticlike properties. Additionally, unlike many other polymers, it can be synthesized over a wide range of molecular weights, and molecular and compositional distributions. This enables EPDM to be produced as a material tailored to the end-use application.
Internet Media Streaming Using Network Coding and Path Diversity (2008)

Delivering live media content over best-effort Internet is a challenging task due to a number of factors such as packet loss, delay, and bandwidth fluctuation. As a result, many approaches have been proposed ranging from auto repeat request-typed solutions, forward error correcting code to routing and scheduling protocols and network architecture design. Multiple path streaming is an important solution which exploits the path diversity to satisfy the high transmission bandwidth requirement of streaming applications. Recently, network coding has been proposed for efficient information dissemination over packet-switched networks. In this paper, we propose a network coding framework for multiple path streaming over the Internet. In particular, we use a number of random network coding schemes in order to both exploit the benefits of path diversity and prevent packet loss. Our framework works at the application layer using the UDP service and is independent of the current network infrastructure.
Adhesion of Human ProbioticLactobacillus rhamnosusto Cervical and Vaginal Cells and Interaction with Vaginosis-Associated Pathogens (2008)

The ability of Lcr35 to adhere to cervicovaginal cells and its antagonist activities against vaginosis-associated pathogens suggest that this probiotic strain is a promising candidate for use in therapy.
[P‐002]: Proton magnetic resonance spectroscopy in Alzheimer's mouse model (2005)

Proton magnetic resonance spectroscopy offers a non-invasive way to quantify many metabolites in vivo. Metabolite levels are sensitive to different in vivo pathologic processes; e.g. N-acetylaspartate (NAA) is a marker for neuronal number and health, and myo-inositol (mIns) is thought to be a marker for osmotic stress. Transgenic mouse models have been developed for Alzheimer's disease (AD). Recently spectroscopic analyses of single transgenic amyloid precursor protein (APP) mice brains showed altered neurochemical profiles. Mice that are doubly transgenic for human APP and presenilin mutations (APP-PS1) develop “human-like” plaques at a younger age than APP mice. The purpose of this study was to characterize the neurochemical profile in APP-PS1 AD mice using high resolution single voxel 1H NMR compared to that of wild-type mice and to determine the changes in the neurochemical profile with age. In vivo 1H NMR spectra from twenty seven APP-PS1 and thirty B6SLJ wild type mice spanning the age from 66 to 904 days were obtained using a previously described LASER sequence at 9.4 T (31 cm horizontal bore magnet equipped with Varian INOVA console) from an 18 μL voxel placed in the cortex and hippocampus. The age dependent neurochemical changes observed in doubly transgenic Alzheimer's mice match expectations based on prior in vivo human MRS studies. Data averaged from all animals also demonstrated decreases in the concentration of both NAA and Glu for both wild-type and APP-PS1 mice across age. The most consistent and profound finding observed was an increase in mIns across age in AD mice (reported as a ratio of concentration of mIns to cretaine/phosphocreatine (Cr/PCr in Figure). Activated microglia accumulate at the periphery of amyloid plaques both in human AD and in transgenic AD mice. It is believed that microglial activation may be responsible for at least some of the neuronal damage which characterizes AD. In theory, MRS could be used to measure the specific feature of AD pathology longitudinally and could serve as an in vivo biomarker of the efficacy of therapeutic measures designed to reduce neuronal damage mediated by microglial activation.
A High-Performance Asynchronous FPGA: Test Results (2005)

We report test results from a prototype asynchronous FPGA (AFPGA) implemented in TSMC's 0.18 /spl mu/m CMOS process. The AFPGA uses SRAM-based configuration bits with pipelined logic blocks and switch boxes. Test results demonstrate a throughput of 674 MHz at 1.8 V.
Concentrator Photovoltaic Qualification Standards for Systems Using Refractive and Reflective Optics: Preprint (2004)

This paper describes a proposed international qualification standard for photovoltaic (PV) systems generating electricity from concentrated sunlight. The standard's purpose is to provide stress tests and procedures to identify any component weaknesses in a system. If no weaknesses are identified during qualification, both the manufacturer and the customer can expect a more reliable product. In 2002, we began developing the standard, under the auspices of the International Electrotechnical Commission (IEC), that would describe testing procedures for concentrator PV systems using reflecting (mirrors) or refractive (lenses) optics for focusing sunlight onto solar cells. The initial draft of the IEC standard was based on the first concentrator PV qualification standard published by the Institute of Electrical and Electronics Engineers (IEEE) in the United States in 2001. Well-developed U.S. concentrator technologies use refractive optics, and the IEEE standard needed improvement for testing systems with reflective optics. Furthermore, with record III-V solar cell efficiencies above 37%, concentrator PV developers around the world would like to incorporate such cells into their next generation of technologies. The paper will highlight significant differences between the proposed IEC standard and the earlier IEEE standard.
Assessment of pulmonary uptake in post-therapy I-131 whole body scan in well differentiated thyroid cancer patients (2009)

In this study, a set of 15 bisphenols (BPs) and one emerging derivative (4-hydroxyphenyl 4-isoprooxyphenylsulfone, BPSIP) were analyzed in 60 pairs of maternal plasma, cord plasma, and placenta samples from pregnant women in South China. A total of 4 of the 15 target BPs, i.e., BPA, bisphenol S (BPS), bisphenol AF (BPAF), and bisphenol E (BPE), were frequently detected in the three human biological matrixes. The derivative BPSIP was identified in all maternal plasma samples at unexpectedly high levels, second only to BPA. The concentrations of bisphenols in maternal plasma were slightly higher than in cord plasma for BPA, BPS, and BPE but much higher for BPSIP and much lower for BPAF, indicating that the five frequently detected bisphenols have different placental transfer behaviors. The placental transfer efficiencies (PTEs) of BPA, BPS, and BPE were similar, which were significantly higher than the PTE of BPSIP. The PTE of BPAF was much higher than other BPs, indicating its strong maternal transfer and high fetal accumulation. The PTEs of bisphenols were structure-dependent, and passive diffusion was suggested as the potential mechanism of placental transfer. Significant concentration correlations of the five major bisphenols between maternal plasma and cord plasma were observed (<i>p</i> < 0.05). Meanwhile, significant associations of BPAF concentrations in maternal/cord plasma with some maternal characteristics and adverse birth outcomes were also identified (<i>p</i> < 0.05).
( 14 ) Über das Haarsche Mass in der lokal bikompakten Gruppe (2015)

Zur Definition des Haarschen Masses m in einer lokal bikompakten, nicht separablen Gruppe gibt es zwei MSglichkeiten.Nach der ersten gewShnlichen Definition wird m zuni.chstffir alle Borelschen Mengen erkl/rt und dann zum vollstndigen Mass vervollst/indigt; nach der zweiten wird dagegen m zun/chst nur fir die Mengen mit Baireschen charakteristischen Funktionenwir
Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data (2021)

Currently, a significant proportion of cancer patients do not benefit from programmed cell death-1 (PD-1)-targeted therapy. Overcoming drug resistance remains a challenge. In this study, single-cell RNA sequencing and bulk RNA sequencing data from samples collected before and after anti-PD-1 therapy were analyzed. Cell-cell interaction analyses were performed to determine the differences between pretreatment responders and nonresponders and the relative differences in changes from pretreatment to posttreatment status between responders and nonresponders to ultimately investigate the specific mechanisms underlying response and resistance to anti-PD-1 therapy. Bulk-RNA sequencing data were used to validate our results. Furthermore, we analyzed the evolutionary trajectory of ligands/receptors in specific cell types in responders and nonresponders. Based on pretreatment data from responders and nonresponders, we identified several different cell-cell interactions, like WNT5A-PTPRK, EGFR-AREG, AXL-GAS6 and ACKR3-CXCL12. Furthermore, relative differences in the changes from pretreatment to posttreatment status between responders and nonresponders existed in SELE-PSGL-1, CXCR3-CCL19, CCL4-SLC7A1, CXCL12-CXCR3, EGFR-AREG, THBS1-a3b1 complex, TNF-TNFRSF1A, TNF-FAS and TNFSF10-TNFRSF10D interactions. In trajectory analyses of tumor-specific exhausted CD8 T cells using ligand/receptor genes, we identified a cluster of T cells that presented a distinct pattern of ligand/receptor expression. They highly expressed suppressive genes like HAVCR2 and KLRC1, cytotoxic genes like GZMB and FASLG and the tissue-residence-related gene CCL5. These cells had increased expression of survival-related and tissue-residence-related genes, like heat shock protein genes and the interleukin-7 receptor (IL-7R), CACYBP and IFITM3 genes, after anti-PD-1 therapy. These results reveal the mechanisms underlying anti-PD-1 therapy response and offer abundant clues for potential strategies to improve immunotherapy.
(Bis{2,4,6-triisopropylphenyl}stannylene)ferrocenophane and Related Ring-Opened Products (1999)

The addition of bis(2,4,6-triisopropylphenyl)tin dichloride (1) to a hexane/THF slurry of 1,1‘-dilithioferrocene−tmeda produces the corresponding stannyleneferrocenophane (2) in good yield. Structural analysis of 2 reveals a dihedral angle between the two cyclopentadienyl rings of 14.7° and a relatively short Fe−Sn atomic distance of 2.994(2) Å. Cyclic voltammetry of 2 exhibits reversible redox behavior. Whereas treatment with MeOH and H2O failed to produce ring-opened compounds, silica gel catalyzed hydrolysis of 1 leads to ring-opened Fc(i-Pr3C6H2)2SnOH (3), which crystallizes as a H-bonded dimer. Thermal treatment of 2 at 180 °C leads to the ring-opened polymerization product 4, which after precipitation from toluene remains insoluble in organic solvents. Solid-state 13C and 119Sn NMR spectra of 4 confirm the structure of the material. The X-ray structural analysis of 1 is reported and compared to that of 2.
The 'hashtag': A new word or a new rule? (2015)

Born as a topic marker to make tweets searchable, today the pound symbol is gaining&#13;\npopularity not only on other social platforms, but also offline, with hashtags&#13;\nincreasingly appearing in the linguistic landscape (e.g. headlines, advertising,&#13;\npolitical slogans). This paper analyzes hashtagging as a productive process of wordformation in English and Italian, both online and offline. The analysis is based on&#13;\nsamples of hashtags from a corpus of tweets and samples appearing in the offline&#13;\nworld. The study proposes a tentative taxonomy of hashtag types and poses questions&#13;\non the nature of the ‘products’ of hashtagging. It also comments on the pragmatic&#13;\nexploitation of the collected samples.
Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity (2014)

Quang and J. Wu for helpful discussion.They would also like to acknowledge dbGaP repository for providing the cancer sequencing datasets.The accession numbers for the breast cancer, pancreatic cancer and prostate cancer datasets are phs000369.v1.p1, phs000516.v1.p1 and phs000447.v1.p1, respectively.
Evaluating Configurations of Double Surface Helical Groove Seals Using Computational Fluid Dynamics (2018)

Helical groove seals are non-contacting annular seals used in pumps and other rotating machinery to reduce the flow of working fluid across a pressure differential. These seals have continuously cut grooves, like the threads of a screw, across the surface of the rotor, the stator, or both surfaces. They function to reduce the flow of working fluid by two physical mechanisms. First, fluid traveling in the axial direction dissipates kinetic energy as it expands in the grooves and then is forced to contract in the jet stream region between the grooves. Second, the fluid within the grooves is displaced toward the high pressure region through the pumping action of the helical grooves. In multistage pump design, it is now common to use helical groove seals with grooves on both the surface of the rotor and stator where the grooves are opposing in direction. That is, the case where the grooves on the rotor pump towards the outlet, but the grooves on the stator pump towards the inlet. Despite this being the industry standard, no data in the literature exist that suggests that this design is better than other possible double surface helical groove seal configurations. This work examines the conditions in which each configuration of double surface helical groove seals is preferable. To accomplish this, simulations are run using ANSYS CFX for a variety of operating conditions for each configuration. The operating conditions varied are pressure differential and rotor speed. The baseline design of this data is a validated against experimental results from the literature showing the performance of opposing groove direction helical groove seals. This paper also discusses the validity of the multi-reference frame steady-state setup that can be used to efficiently simulate these seals. Finally, this study presents discussion and conclusions of the preference to opposing direction helical groove seals based on the flow mechanisms of the seal configurations. This work will form the basis of future work designing computationally efficient analysis tools to analyze these double surface helical groove seals, which are already widely used but lack computational analysis tools.