gebhart/patrepeval huggingface dataset:
Sequencing and de novo transcriptome assembly of Anthopleura dowii Verrill (1869), from Mexico (2016)

Next-generation technologies for determination of genomics and transcriptomics composition have a wide range of applications. Moreover, the development of tools for big data set analysis has allowed the identification of molecules and networks involved in metabolism, evolution or behavior. By natural habitats aquatic organisms have implemented molecular strategies for survival, including the production and secretion of toxic compounds for their predators; therefore these organisms are possible sources of proteins or peptides with potential biotechnological application. In the last decade anthozoans, mainly octocorals but also sea anemones, have been proben to be a source of natural products. Members of the genus <i>Anthopleura</i> are one of the best known and most studied sea anemones because they are common constituents of rocky intertidal communities and show interesting ecological and biological phenomena (e.g. intraespecific competition, symbiosis, etc.); however, many aspects of these taxa remain in need to be analyzed. This work describes the transcriptome sequencing of <i>Anthopleura dowii</i> Verrill, 1869 (Cnidaria: Anthozoa: Actiniaria); this is the first report of this kind for these species. The data set used to construct the transcriptome has been deposited on NCBI's database. Illumina sequence reads are available under BioProject accession number PRJNA329297 and Sequence Read Archive under accession number SRP078992.
Melatonin: A New Probe in Psychiatric Investigation? (1989)

The pineal gland, Descartes' seat of the soul, was variously considered until recently as a somewhat mysterious vestigial organ, or simply a good neuroradiological marker. The former point of view arose partly out of ignorance and the curious mythical associations related to its function as a ‘third eye’ in some lower vertebrates. The latter is due to the calcification which is present in most adult human pineal glands.
Composition of RF-sputtered ZnS films (1978)

Rutherford back-scattering and X-ray photoelectron spectroscopy (XPS) have been used to study the stoichiometry and chemical composition of RF-sputtered thin films of ZnS. The results show that stoichiometry of the starting material is no guarantee of stoichiometry in the final film. Films grown in the normal way have a high oxygen content and a Zn/S ratio much greater than unity. XPS shows these films to be a ZnO+ZnS mixture. To obtain low oxygen content and good stoichiometry a good starting vacuum and high throughput of sputtering gas (argon) are necessary.
An improved technique for preservation of endothelial morphology in vein grafts. (1981)

Scanning electron microscopy was performed on 29 canine and two human veins prepared for vein grafting by means of various techniques. Endothelial morphology was best preserved when veins were pretreated with papaverine before excision, when a warm solution was used for dilatation, when the grafts were stored up to 1 hour either in a warm, nutritive medium (Dulbecco's modified eagles) or a cold, nonnutritive solution (saline), and when the grafts were maintained in the distended state. Distending pressure up to 500 mm Hg did not cause injury to veins prepared by these techniques. The use of cold solutions to distend veins was especially harmful.
Electrochemical Character and Application of Halide Mediators Using CF3CH2oh As Solvent (2015)

The electrochemical characteristics of bromide and iodide in 2,2,2-trifluoroethanol (TFE) has been investigated and studied by cyclic voltammetry. TFE is a protic solvent that has different nucleophilicity compared to other common alcohol solvents. Based on the experimental results, iodide and bromide lose two electrons and form a triiodie/tribromide system in one oxidation wave in TFE. The processes were found to be diffusion-controlled. Different types of electrochemical reactions were attempted and studied in TFE. TFE found to be useful for the synthesis and benzylic C-H bond activation.
Measurement of BHA Vibration Using MWD (1988)

Abstract Excessive drill string vibration can lead to partial or catastrophic failure of bottom hole assembly (BHA) components. This paper presents data from a microprocessor based downhole vibration data acquisition and recording system, located within a host MWD (Measurement While Drilling) collar in the BHA. Four case studies of vibration levels attained during commercial drilling operations are presented. These examples include vibration monitoring during reaming, drilling a casing shoe, and drilling new formation. Generally, lateral accelerations were an order of magnitude greater than longitudinal accelerations. In one example, catastrophic failure of MWD components resulted from sustained high-level lateral vibrations. Data collected to-date has been used to optimize BHA components and define the down hole vibrational environment. Future information obtained by the monitoring system will be of value in verifying and calibrating computer models.
Adaptive image coding with perceptual distortion control (2002)

This paper presents a discrete cosine transform (DCT)-based locally adaptive perceptual image coder, which discriminates between image components based on their perceptual relevance for achieving increased performance in terms of quality and bit rate. The new coder uses a locally adaptive perceptual quantization scheme based on a tractable perceptual distortion metric. Our strategy is to exploit human visual masking properties by deriving visual masking thresholds in a locally adaptive fashion. The derived masking thresholds are used in controlling the quantization stage by adapting the quantizer reconstruction levels in order to meet the desired target perceptual distortion. The proposed coding scheme is flexible in that it can be easily extended to work with any subband-based decomposition in addition to block-based transform methods. Compared to existing perceptual coding methods, the proposed perceptual coding method exhibits superior performance in terms of bit rate and distortion control. Coding results are presented to illustrate the performance of the presented coding scheme.
Measuring the Fault Predictability of Software using Deep Learning Techniques with Software Metrics (2018)

Minimization of failures is the major expectation from reliable software. Predicting the software faults supports in identifying the location in the faulty modules for detailed testing to increase the maintainability. This paper presents fault prediction using some of the deep learning techniques utilizing source code metrics of the software. Accuracy, f-measure, recall, precision, receiver operating characteristic (ROC) curves and area under curve (AUC) values are considered to measure the performance of the deep learning methods. Experimental analysis on five NASA public benchmarked datasets depict Convolutional Neural Network (CNN) classifier as a more robust software fault prediction model achieving the highest accuracy rates. CNN is followed by Artificial Neural Network (ANN) and then Self-Organizing Map (SOM). Learning Vector Quantization (LVQ) version 3 and MultiLVQ have the worst performance on software fault prediction using software metrics.
High-pressure Cold Isostatic Pressing of Ultra-fine Oxide Powders. (1993)

Al2O3, MgO, SiO2の各種粒子径の酸化物系超微粒子を, 1GPaまでの等方高圧により成形した.3種類の粉体とも, 一次粒子径21nm以下の超微粒子の成形体相対密度が1GPaの等方高圧により最大60%まで向上した.超微粒子の強く粗な凝集構造が高圧によりほぼ完全に破壊され, 成形体内の細孔も一次粒子径より小さくできた.特にMgO微粒子では成形圧力1GPaの条件で, 最大相対密度80%, 細孔モード径は比表面積換算径の20%以下まで減少した.しかし粒子径100nm以上のAl2O3粉体では.圧力を増加させても密度, 細孔径ともあまり変化せず, 高圧は緻密化や成形体内空隙の微細化にあまり有効ではなかった.超微粒子成形体の高圧による緻密化機構を考察するため, 一次粒子接触点に働く力, 発生応力を修正Rumpf式およびHertz式により推定した.また粒子内部に生じる最大引っ張り応力も計算し, 粒子強度や塑性降伏値との比較を行った.その結果, 接触点での著しい塑性変形や粒子破壊現象は起きていないことが確認された.また一次粒子径に対する成形体内の細孔モード径の比と成形体相対密度の関係が, 球形単分散粒子の充填構造の場合とほほ一致した.したがって本報の実験範囲では, 凝集体構造の破壊による一次粒子再配列機構が緻密化の支配機構であることが確認された.
Ablation of Growth Hormone Receptor in GABAergic Neurons Leads to Increased Pulsatile Growth Hormone Secretion (2022)

Growth hormone (GH) acts in several hypothalamic neuronal populations to modulate metabolism and the autoregulation of GH secretion via negative-feedback loops. However, few studies have investigated whether GH receptor (GHR) expression in specific neuronal populations is required for the homeostatic control of GH secretion and energy homeostasis. In the present study, we investigated the consequences of the specific GHR ablation in GABAergic (VGAT-expressing) or glutamatergic (VGLUT2-expressing) cells. GHR ablation in GABAergic neurons led to increased GH secretion, lean mass, and body growth in male and female mice. VGAT-specific GHR knockout (KO) male mice also showed increased serum insulin-like growth factor-1, hypothalamic Ghrh, and hepatic Igf1 messenger RNA levels. In contrast, normal GH secretion, but reduced lean body mass, was observed in mice carrying GHR ablation in glutamatergic neurons. GHR ablation in GABAergic cells increased weight loss and led to decreased blood glucose levels during food restriction, whereas VGLUT2-specific GHR KO mice showed blunted feeding response to 2-deoxy-D-glucose both in males and females, and increased relative food intake, oxygen consumption, and serum leptin levels in male mice. Of note, VGLUT2-cre female mice, independently of GHR ablation, exhibited a previously unreported phenotype of mild reduction in body weight without further metabolic alterations. The autoregulation of GH secretion via negative-feedback loops requires GHR expression in GABAergic cells. Furthermore, GHR ablation in GABAergic and glutamatergic neuronal populations leads to distinct metabolic alterations. These findings contribute to the understanding of the neuronal populations responsible for mediating the neuroendocrine and metabolic effects of GH.
ChemInform Abstract: Highly Efficient Regio and Diastereoselective Synthesis of Functionalized Bis‐Spirooxindoles and Their Antibacterial Properties. (2016)

Abstract In this simple method for the preparation of the title compounds, only a small amount of CAN as catalyst is required.
Topics in Decentralized Detection (1992)

In this thesis we obtain several new results in the areas of decentralized sequential detec-tion and robust decentralized detection. In the area of decentralized sequential detection, we first consider the case in which each sensor performs a sequential test on its observations and arrives at a local decision about the true hypothesis; subsequently, the local decisions of all of the sensors are used for a common purpose. Here we assume that decision errors at the sensors are penalized through a common cost function and that each time step taken by the detectors as a team is assigned a positive cost. We show that optimal sensor decision functions can be found in the class of generalized sequential probability ratio tests with monotonically convergent thresholds. We present a technique for obtaining optimal thresholds. We also consider the case in which each sensor sends a sequence of summary messages to a fusion center in which a sequential test is carried out to determine the true hypothesis. Here we assume that decision errors at the fusion center are penalized through a cost function and that each time step taken to arrive at the final decision costs a positive amount. We show that the problem is tractable when the information structure in the system is quasiclassical. In
A Case of Placenta Praevia Centralis, with Spontaneous Delivery of the Child (1921)

TMEnDICALTOtsmBlareh,
Carrier Screening is a Deficient Strategy for Determining Sperm Donor Eligibility and Reducing Risk of Disease in Recipient Children (2016)

Despite tremendous advances in variant identification, understanding, and analysis, the vast majority of disease-causing mutation combinations remain undetected by commercial carrier screening panels, which cover a narrow, and often distinct, subset of genes and mutations. The biological reality is that all donors and recipients carry serious recessive disease mutations. This challenges the utility of any screening protocol that anchors donor eligibility to carrier status. A more effective approach to reducing recessive disease risk would consider joint comprehensive analysis of both donor and recipient disease mutations. This type of high-resolution recessive disease risk analysis is now available and affordable, but industry practice must be modified to incorporate its use.
Advances in Male Contraception (2008)

Despite significant advances in contraceptive options for women over the last 50 yr, world population continues to grow rapidly. Scientists and activists alike point to the devastating environmental impacts that population pressures have caused, including global warming from the developed world and hunger and disease in less developed areas. Moreover, almost half of all pregnancies are still unwanted or unplanned. Clearly, there is a need for expanded, reversible, contraceptive options. Multicultural surveys demonstrate the willingness of men to participate in contraception and their female partners to trust them to do so. Notwithstanding their paucity of options, male methods including vasectomy and condoms account for almost one third of contraceptive use in the United States and other countries. Recent international clinical research efforts have demonstrated high efficacy rates (90-95%) for hormonally based male contraceptives. Current barriers to expanded use include limited delivery methods and perceived regulatory obstacles, which stymie introduction to the marketplace. However, advances in oral and injectable androgen delivery are cause for optimism that these hurdles may be overcome. Nonhormonal methods, such as compounds that target sperm motility, are attractive in their theoretical promise of specificity for the reproductive tract. Gene and protein array technologies continue to identify potential targets for this approach. Such nonhormonal agents will likely reach clinical trials in the near future. Great strides have been made in understanding male reproductive physiology; the combined efforts of scientists, clinicians, industry and governmental funding agencies could make an effective, reversible, male contraceptive an option for family planning over the next decade.
Laser Spectroscopy for Atmospheric and Environmental Sensing (2009)

Lasers and laser spectroscopic techniques have been extensively used in several applications since their advent, and the subject has been reviewed extensively in the last several decades. This review is focused on three areas of laser spectroscopic applications in atmospheric and environmental sensing; namely laser-induced fluorescence (LIF), cavity ring-down spectroscopy (CRDS), and photoluminescence (PL) techniques used in the detection of solids, liquids, aerosols, trace gases, and volatile organic compounds (VOCs).
Structural Ceramic Components by 3D Printing (2018)

The Three Dimensional Printing (3DP) Process hasbe~nadapted for processing of fine&#13;\nceramic powders to •• prepare structllraLceramic components. Our preliminary study was&#13;\ndesigned to reveal those aspects ofthe.3DPprocesswhichmust be modified for use with&#13;\nfine ceramic powders. The basic elements of the modified process are to spread&#13;\nsubmicron alumina powder and printJatex binder. Several methods were used to spread&#13;\nthin layers of submicron powders. Gre.enparts are isostaticaUypressed followed by&#13;\nthermal decomposition prior to sintering to remove the polymer. The fired alumina&#13;\ncomponents are greater than 99.2% dense and have·average flexural strength of324 MPa.&#13;\nThis is lower than the best conventionally prepared alumina, but we believe that the&#13;\nstrength results will improve as we learn more about the relationship between strength&#13;\nlimiting flaws and the 3DP build process.
In vivo Comparison of Changes in Glenohumeral Translation after Arthroscopic Capsulolabral Reconstructions (2008)

Arthroscopic superior capsulolabral reconstructions successfully restored anteroposterior translation. However, arthroscopic capsulolabral techniques for treating recurrent anterior or posterior instability resulted in decreased anteroposterior translation compared to the uninvolved side while restoring external rotation.
Muscodor albusstrain GBA, an endophytic fungus ofGinkgo bilobafrom United States of America, produces volatile antimicrobials (2010)

Muscodor albus strain GBA is a newly isolated endophytic fungus from Ginko biloba (family Ginkoaceae) collected in Newport, RI, USA. The cultural characteristics (color, growth pattern) and mycelial/hyphal characteristics resemble many isolates of Muscodor albus. The ITS rDNA sequence of the strain has at least 98% similarity with other isolates of M. albus and M. crispans. This xylariaceaous species effectively inhibits and kills certain test microbes via a mixture of volatile organic compounds (VOCs) that it produces. Some of the target test microbes were totally inhibited by M. albus strain GBA and not by other M. albus isolates, making this isolate unique in its biological activity. The VOCs of this fungus were identified by gas chromatography/mass spectrometry as esters, lipids, alcohols, acids and ketones, including proportionally large quantities of 1-butanol, 3-methyl-, acetate. A terpenoid, not observed in other strains of this fungus, vitrene was tentatively identified in the VOCs of this organism. This is the first record of M. albus in Ginko biloba and is the first report of any M. albus strain from the United States. The organism is normally found in tropical latitudes (16° north/ south) but the plant host M. albus strain GBA is located at 41° north latitude. Most importantly, however, the discovery of M. albus in the USA has enormous implications vis-a.vis governmental regulation of M. albus for use as a biological control agent in agriculture and industry, as this organism naturally occurs in the USA. A discussion on the relationship of this taxon with its host is also included.
A nonreflecting boundary condition for discrete acoustic and elastic wave equations (1985)

Abstract One of the nagging problems which arises in application of discrete solution methods for wave-propagation calculations is the presence of reflections or wraparound from the boundaries of the numerical mesh. These undesired events eventually override the actual seismic signals which propagate in the modeled region. The solution to avoiding boundary effects used to be to enlarge the numerical mesh, thus delaying the side reflections and wraparound longer than the range of times involved in the modeling. Obviously this solution considerably increases the expense of computation. More recently, nonreflecting boundary conditions were introduced for the finite-difference method (Clayton and Enquist, 1977; Reynolds, 1978). These boundary conditions are based on replacing the wave equation in the boundary region by one-way wave equations which do not permit energy to propagate from the boundaries into the numerical mesh. This approach has been relatively successful, except that its effectiveness degrades for events which impinge on the boundaries at shallow angles. It is also not clear how to apply this type of boundary condition to global discrete methods such as the Fourier method for which all grid points are coupled.
New device with force sensors for laparoscopic liver resection – investigation of grip force and histological damage (2020)

The new device is necessary for preventing liver damage in laparoscopic hepatic resection.
Dummy Filling Methods for Reducing Interconnect Capacitance and Number of Fills (2005)

In recent system-on-chip (SoC) designs, floating dummy metals inserted for planarization have created serious problems because of increased interconnect capacitance and the enormous amount of fill required. We present new methods to reduce the interconnect capacitance and the amount of dummy metals needed. These techniques include three ways of filling: (1) improved floating square fills, (2) floating parallel lines, and (3) floating perpendicular lines (with spacing between dummy metals above and below signal lines). We also present efficient simple formulas for estimating the appropriate spacing and number of fills. In our experiments, the capacitance increase using the traditional regular square method was 13.1%, while that using the methods of improved square fills, extended parallel lines, and perpendicular lines was 2.5%, 2.4%, and 1.1%, respectively. Moreover, the number of necessary dummy metals can be reduced by two orders of magnitude through use of the parallel line method.
The Effect of Collector Region Design on Large-Signal Performance of Horizontal Current Bipolar Transistor (HCBT) (2023)

The impact of collector region design on large-signal performance of horizontal current bipolar transistor (HCBT) technology is investigated by calibrated time-domain load-pull measurements. Three representative high-performance devices of the same geometry but with different collector doping profiles, namely, uniform, n-well, and low-doped, are subjected to large-signal measurements wherein the radio frequency (RF) time-domain waveforms of current and voltage are measured to facilitate the determination of the maximum output power for each device. The extensive measurements outline the boundaries of the maximum collector current and voltage swings at RF determining linear operating area, which are a result of the physical phenomena in the high-current and high-voltage regimes, namely, the Kirk effect and impact ionization, respectively. While the highest-doped n-well HCBT provides the highest output power of 25.3 dBm at 1-dB gain compression, and the lowest-doped HCBT enables a wideband match at the collector, the HCBT with a uniform doping profile provides a tradeoff between the output power and bandwidth of the output match. The results show the versatility of HCBT technology as an alternative to CMOS and/or sillicon–germanium (SiGe) large-signal RF circuits for the front-ends (FEs) in the sub-6 GHz wireless communications range.
Output analysis: analysis of simulation output (2003)

We discuss methods for statistically analyzing the output from stochastic discrete-event or Monte Carlo simulations. Both terminating and steady-state simulations are considered.
Molecular and Clinical Studies in 138 Japanese Patients with Silver-Russell Syndrome (2013)

The results are grossly consistent with the previously reported data, although the frequency of epimutations is lower in the Japanese SRS patients than in the Western European SRS patients. Furthermore, the results provide useful information regarding placental hypoplasia in SRS, clinical phenotypes of the hypomethylated ARHI-DMR, and underlying causative factors for idiopathic SRS.
Management of intrauterine fetal demise and missed abortion using prostaglandin E2 vaginal suppositories. (1976)

Two hundred and twelve patients diagnosed as having a missed abortion or intrauterine fetal death were managed by the use of prostaglandin E2 vaginal suppositories. The method had a high efficacy rate with 98% of the patients experiencing successful evacuation of the uterine contents. The mean time to abortion was 10.9 hours with a mean dose of 60 mg (3 suppositories). Side effects were well tolerated. Transient pyrexia was present in 36% of the patients during therapy, but returned to pretreatment levels after abortion. No intrauterine infection was observed. The risks associated with active treatment can be avoided. The ease of administration permits initiation of therapy as soon as the diagnosis is confirmed.
The Spallation Neutron Source RF Reference System (2006)

The Spallation Neutron Source (SNS) RF Reference System includes the master oscillator (MO), local oscillator(LO) distribution, and Reference RF distribution systems. Coherent low noise Reference RF signals provide the ability to control the phase relationships between the fields in the front-end and linear accelerator (linac) RF cavity structures. The SNS RF Reference System requirements, implementation details, and performance are discussed.