gebhart/patrepeval huggingface dataset:
High-affinity antibodies to the 1,4-dihydropyridine Ca2+-channel blockers. (1986)

Antibodies with high affinity and specificity for the 1,4-dihydropyridine Ca2+-channel blockers have been produced in rabbits by immunization with dihydropyridine-protein conjugates. Anti-dihydropyridine antibodies were found to specifically bind [3H]nitrendipine, [3H]-nimodipine, [3H]nisoldipine, and [3H]PN 200-110 (all 1,4-dihydropyridine Ca2+-channel blockers) with high affinity, while [3H]verapamil, [3H]diltiazem, and [3H]trifluoperazine were not recognized. The average dissociation constant of the [3H]nitrendipine-antibody complex was 0.06 (+/- 0.02) X 10(-9) M for an antiserum studied in detail and ranged from 0.01 to 0.24 X 10(-9) M for all antisera. Inhibition of [3H]nitrendipine binding was specific for the 1,4-dihydropyridine Ca2+-channel modifiers and the concentrations required for half-maximal inhibition ranged between 0.25 and 0.90 nM. Structurally unrelated Ca2+-channel blockers, calmodulin antagonists, inactive metabolites of nitrendipine, and UV-inactivated nisoldipine did not modify [3H]nitrendipine binding to the anti-dihydropyridine antibodies. Dihydropyridines without a bulky substituent in the 4-position of the heterocycle were able to displace [3H]nitrendipine binding, but the concentrations required for half-maximal inhibition were greater than 800 nM. In summary, anti-dihydropyridine antibodies have been shown to have high affinity and specificity for the 1,4-dihydropyridine Ca2+-channel blockers and to exhibit dihydropyridine binding properties similar to the membrane receptor for the 1,4-dihydropyridine Ca2+-channel blockers.
Organic Sulfur Derivatives. I. Addition of Mercaptoacetic Acid to Long-chain Monounsaturated Compounds (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic Sulfur Derivatives. I. Addition of Mercaptoacetic Acid to Long-chain Monounsaturated CompoundsN. H. Koenig and Daniel SwernCite this: J. Am. Chem. Soc. 1957, 79, 2, 362–365Publication Date (Print):January 1, 1957Publication History Published online1 May 2002Published inissue 1 January 1957https://pubs.acs.org/doi/10.1021/ja01559a033https://doi.org/10.1021/ja01559a033research-articleACS PublicationsRequest reuse permissionsArticle Views215Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Airway Bypass Improves the Mechanical Properties of Explanted Emphysematous Lungs (2008)

Because these data show that airway bypass improves the mechanics of breathing in severely emphysematous lungs in vitro, there is now strong empirical support that this procedure can improve ventilatory function in patients by reducing gas trapping and flow resistance.
Ytterbium triflate catalysed Friedel–Crafts reaction using carboxylic acids as acylating reagents under solvent-free conditions (2009)

The Friedel–Crafts acylation of 1-naphthol and phenol derivatives with carboxylic acids were investigated by using a catalytic amount of metal-triflate, in particular Yb(OTf) 3 , under solvent-free conditions. Both aliphatic and aromatic carboxylic acids reacted easily to afford the corresponding hydroxyaryl ketones.
A 2mW CMOS MICS-band BFSK transceiver with reconfigurable antenna interface (2010)

A 0.18µm CMOS MICS-band transceiver with a reconfigurable RF front-end is presented, reusing the same circuit core for super-regenerative wake-up receiver, receive-mode LNA, and transmit power amplifier, eliminating the need for an external T/R switch. The transceiver uses an All Digital Frequency Locked-Loop (ADFLL) for LO signal generation and transmitter's modulation. The OOK wake-up receiver sensitivity is −80dBm @ 50kbps, while the BFSK receiver's sensitivity is −97dBm for a 75kbps signal and 2mW power consumption. The nominal output power of the transmitter is −5dBm.
Assigning value to stimulation in the Barnett Shale: a simultaneous analysis of 7000 plus production hystories and well completion records (2009)

Abstract Analysis of publicly available monthly production history and well completion records can shed light onto such long-standing questions as 1) what is the value of a stimulation (re-stimulation) treatment in the Barnett Shale, 2) how does the ultimate recovery depend on treatment type and size, 3) what factors determine the performance of a fractured well. This study starts with the month-by-moth analysis of production history for all gas wells in the Barnett Shale. Using a specialized decline-curve analysis methodology developed for shale gas wells, significant production behavior changes are automatically detected and jumps in estimated ultimate recoveries are calculated for individual wells as well, as for groups of wells. The study then continues with the textual analysis of publicly available well completion records consisting of more than 16 Gigabyte data. The obtained database is submitted to analysis relating ultimate recovery to well inclination, to location, to treatment parameters, etc.
Immune Complexes Induce Monocyte Survival through Defined Intracellular Pathways (2007)

Monocytes recruitment and survival at sites of inflammation are determinant for the persistence of inflammatory reactions. Immune-complexes (ICs), whose tissue deposition is involved in a variety of autoimmune diseases, activate monocytes through the interaction with Fcgamma-receptor triggering the secretion of several inflammatory modulators and favoring their tissue accumulation by inhibiting the apoptosis. To elucidate the intracellular pathways governing this process, on the basis of our previous findings regarding the dose-dependent inhibition of apoptosis in IC-activated monocytes, we have investigated the role of PI3K/Akt pathway, MAP kinases, nuclear factor-kappaB (NF-kappaB), and caspase 3, 8, and 9. Here we show that IC-activated monocytes underwent apoptosis at a rate comparable to that of resting monocytes in the presence of LY294002, a selective inhibitor of PI3K, as well in the presence of Akt inhibitor, PD98059 inhibitor of ERK1/2, and SB203580 inhibitor of p38. Moreover, IC-triggered phosphorylation of Akt, ERK1/2, and p38 MAP kinase was demonstrated on Western blot analysis. SN50, an inhibitor of NF-kappaB translocation and BMS345541, a specific inhibitor of IKK, also abolished the apoptosis protection conferred by ICs. In parallel, ICs induced an increase in NF-kappaB activation, as shown by EMSA, together with the expression of XIAP, as shown by Western blot, though indicating that in monocytes IC protection from apoptosis is NF-kappaB dependent. Finally, the activity of caspase 3, 8, and 9 resulted inhibited in IC-activated monocytes. These results disclose a signaling route triggered by ICs which can be involved in the pathophysiology of inflammatory diseases and can represent a target for therapy of IC-mediated diseases.
A Modified Droop Control Algorithm for DC Microgrids to Achieve Accurate Current Sharing and Improved Voltage Regulation (2021)

Droop control is a commonly used method for load current sharing among the converters in DC microgrid applications. However, in this method, the current sharing and load voltage regulation are affected by cable resistances and other non-idealities. The conventional droop control method’s performance can be improved using secondary control algorithms that involve low-bandwidth communication channels. In this paper, an improved secondary control algorithm is proposed for a multi-source, single load bus DC microgrid system. In the proposed algorithm, the load voltage information is communicated to the individual converters, and there are no communication channels between individual converters. Thus the proposed algorithm achieves accurate current sharing and improved load voltage regulation with reduced communication channels compared to several state-of-the-art approaches. All the controllers in the proposed algorithm are implemented locally, and hence a decentralized control is achieved. The proposed algorithm’s effectiveness is validated using circuit simulations and hardware-based experiments on a two converter single load bus DC microgrid system.
Häufigkeit und Risikofaktoren der Augeninnendruckerhöhung nach perforierender Keratoplastik123 (2000)

The development of increased intraocular pressure after PK varied with the indication for keratoplasty. Postkeratoplasty glaucoma seems to be strongly associated with preexisting anterior synechiae and/or simultaneous anterior chamber lens implant removal. Intraoperative iridotomy can prevent the development of acute angle closure glaucoma after keratoplasty.
ChemInform Abstract: A Concise Synthesis of Furostifoline. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multiplex Chemiluminescent Immunoassay Based on Silica Colloidal Crystal Beads (2009)

The paper presented a novel multiplex chemiluminescence (CL) immunoassay method, which was based on silica colloidal crystals beads (SCCBs) as carriers using enhanced chemiluminescence (CL) detection of a horseradish peroxidase (HRP) catalyzing the luminal reaction. The monodisperse and size-controlled SCCBs were fabricated by a microfluidic device. The experimental conditions were optimized and analytical performance was studied. Results showed that the SCCBs as supports were much sensitive (0.05 ng/ml IgG) than the glass beads (18 ng/ml IgG) and the planar carriers (125 ng/ml IgG). A multiplex immunoassay suggested the feasibility of high throughput applications. This novel immunoassay system provided a simple, sensitive and low-cost approach for multianalyte immunoassay without using of expensive array detector.
Antioxidant intake and status, and oxidative stress in relation to breast cancer risk: a case-control study. (2009)

A case control study was carried out to investigate associations between breast cancer risk, antioxidant status and oxidative stress among women in Klang Valley and Selangor. A total of 57 newly diagnosed cases aged 30 to 66 years old participated and were matched for age and ethnicity with 139 controls with no diagnosis of cancer or other chronic diseases. An interview based questionnaire designed to collect information on demographic and socioeconomic status, as well as reproductive, medical and dietary history was used. Anthropometric measurements including weight, height, waist and hip circumference were made and a 10 ml fasting venous blood sample was taken for glucose testing and analysis of plasma vitamin antioxidants and malondialdehyde. Hair and toenail samples were taken for selenium analysis. Results showed that the mean intake of vitamin A, vitamin E and selenium among cases (606.8 +/- 334.8 microg/d, 6.1 +/- 2.4 g/d, 56.9 +/- 16.2 microg/d) was lower than controls (724.7 +/- 414 microg/day, 6.9 +/- 3.0 g/d, 60.8 +/- 17.5 microg/d, respectively) (p<0.05 for all parameters). A similar trend was noted for plasma vitamin A and E and also selenium in hair and toenails. Poor antioxidant status as indicated by low plasma vitamin A (<284.3 microg/l or <366.3 microg/l) increased risk of breast cancer by approximately two fold, whilst low plasma vitamin E (<2.5 mg/dl, <2.8 mg/dl and <3.1 mg/dl) increased the risk by two to three fold [Adjusted OR 2.97 (95% CI 1.38-3.48), 2.32 (95% CI 1.07-2.41) and 2.12 (95% CI 1.00-4.21)]. Cases had a greater level of malondialdehyde 4.4 +/- 1.1 mmol/g protein), an indicator of oxidative stress, as compared to controls (3.2 +/- 1.7 mmol/g protein) (p<0.05). A high level of MDA (> or = 4.8 mmol/g protein) was associated with breast cancer [Adjusted OR 6.82 (95% CI 1.95-23.9)]. It is concluded that a poor antioxidant status and high oxidative stress are associated with breast cancer risk. Thus, it is essential for Malaysian women to obtain a good antioxidant status by consuming a diet rich in vitamins A and E as well as selenium and adopt healthy behaviour to reduce oxidative stress in order to prevent breast cancer.
GABAB-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice (2021)

Some immune system cells express type A and/or type B γ-aminobutyric acid receptors (GABA<sub>A</sub>-Rs and/or GABA<sub>B</sub>-Rs). Treatment with GABA, which activates both GABA<sub>A</sub>-Rs and GABA<sub>B</sub>-Rs), and/or a GABA<sub>A</sub>-R-specific agonist inhibits disease progression in mouse models of type 1 diabetes (T1D), multiple sclerosis, rheumatoid arthritis, and COVID-19. Little is known about the clinical potential of specifically modulating GABA<sub>B</sub>-Rs. Here, we tested lesogaberan, a peripherally restricted GABA<sub>B</sub>-R agonist, as an interventive therapy in diabetic NOD mice. Lesogaberan treatment temporarily restored normoglycemia in most newly diabetic NOD mice. Combined treatment with a suboptimal dose of lesogaberan and proinsulin/alum immunization in newly diabetic NOD mice or a low-dose anti-CD3 in severely hyperglycemic NOD mice greatly increased T1D remission rates relative to each monotherapy. Mice receiving combined lesogaberan and anti-CD3 displayed improved glucose tolerance and, unlike mice that received anti-CD3 alone, had some islets with many insulin<sup>+</sup> cells, suggesting that lesogaberan helped to rapidly inhibit β-cell destruction. Hence, GABA<sub>B</sub>-R-specific agonists may provide adjunct therapies for T1D. Finally, the analysis of microarray and RNA-Seq databases suggested that the expression of GABA<sub>B</sub>-Rs and GABA<sub>A</sub>-Rs, as well as GABA production/secretion-related genes, may be a more common feature of immune cells than currently recognized.
Robust Methods for Solving Systems of Nonlinear Equations (1980)

In solving systems of nonlinear equations, ${\bf f} ( {\bf x} ) = {\bf 0}$, most investigations have concentrated on methods that are efficient if the initial guess is close to a zero of ${\bf f}$. For many problems a good initial guess is not available, and a more robust method is needed. We introduce a new idea based on the singular-value decomposition. Partial-rank “pseudo-Newton” steps are defined which are a natural bridge between the steepest-descent method and Newton’s method, and are particularly useful when the Jacobian matrix has partial rank. Illustrative examples show the improvement possible over the usual hybrid methods which combine steepest descent and Newton’s method.
5-Arylaminopyrimidines1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5-Arylaminopyrimidines1Fred R. Gerns, Agostino Perrotta, and George H. HitchingsCite this: J. Med. Chem. 1966, 9, 1, 108–115Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/jm00319a027https://doi.org/10.1021/jm00319a027research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CONCEPT OF INTERNALLY SEALED CONCRETE (1975)

A promising new process for internally sealing concrete, which prevents the intrusion of chlorides from decicing operations or marine environments and the subsequent deterioration of the concrete, was developed by Monsanto Research Corporation under an FHWA contract. The work is described in Report FHWA-RD-75-20, Internally Sealed Concrete, by G.H. Jenkins and J.M. Butler. This report is intended as a supplement to the above publication. The work was performed to further document the concept of internally sealed concrete and to provide independent evidence that the wax particles which are mixed into the fresh concrete do, upon heating, migrate into the capillaries and voids of the concrete matrix. The scanning electron microscope and an energy dispersive x-ray attachment were used to study heated and unheated concrete containing 2 percent montan wax. The conclusion was that montan wax, when melted, will migrate within, and thourghly coat, the surrounding concrete matrix. /Author/
A review on conducting polymer coatings for corrosion protection (2016)

Corrosion of metals is one of the most important problems in the manufacturing industries. Many corrosion control methods use coatings of conducting polymers and conversion layers that contain toxic and environmentally hazardous materials, especially chromium compounds. These objectives have led to the development of new protective coating strategies that employs nanocomposites and carbon-based materials. In recent years, conducting polymers have attracted much attention because of their wide range of industrial applications and economic viability. Polymers possess long-chain carbon linkages and therefore, upon adsorption are able to block large areas of the corroding metal surfaces. The thin films adsorbed on the metal substrate provide a barrier effect between the metal and its environment. This review article summarizes the different techniques used in corrosion protection of metals, conducting polymers and nanomaterials, nanocomposites, and carbon-based materials in corrosion science.
Anatomy of Highly Expressing Chromosomal Sites Targeted by Retroviral Vectors (1996)

The eukaryotic genome contains chromosomal loci with a high transcription-promoting potential. For their identification in cultured cells, transfer of a reporter gene has to be performed by a technique that grants the integration of individual copies. We have applied retroviral vectors in conjunction with inverse polymerase chain reaction techniques to reconstruct a number of these sites for a further characterization. Remarkably, all examples conform to the same design in that the process of retroviral infection selected a scaffold- or matrix-attached region (S/MAR) that was flanked by DNA with high bending potential. The S/MARs are of an unusual type in that they show a high incidence of certain dinucleotide repeats and the potential to act as topological sinks. The anatomy of retroviral integration sites reveals principles that can be exploited for the development of predictable transgenic systems on the basis of expression and targeting vectors.
Hantering av betalningsstopp i livsmedelsbutiker : En undersökning av hur hanteringen kan förbättras (2017)

A well-functioning infrastructure is the foundation of a stable society, where payment systems are an important part. Grocery stores provide the general public with groceries and rely on customer c ...
Supraglottoplasty in patients with Exercise induced laryngeal obstruction (EILO) (2018)

<b>Introduction:</b> Exercise Induced Inspiratory Symptoms (EIIS) are often confused with symptoms of exercise induced asthma. EIIS is related to laryngeal obstruction in most patients, and was previously attributed to inappropriate adduction of the vocal cords, hence the old label VCD. However, exercise induced laryngeal obstruction (EILO) primarily involves supraglottic structures in a majority of patients with EIIS. Therefore, surgical treatment (supraglottoplasty) has been performed in highly selected and motivated patients with pronounced symptoms and severe supraglottic collapse. <b>Aim:</b> To investigate efficiency and safety of laser supraglottoplasty as treatment for severe supraglottic EILO by retrospective chart reviews. <b>Method:</b> During 2010-2015, 43 patients mean age 16.9 (range 12-25) underwent laser supraglottoplasty due to a severe supraglottic EILO verified using continuous laryngoscopy during exercise (CLE-test). The surgical procedure was performed in general anaesthesia by one of three surgeons, and outcome was evaluated by questionnaire based self-reported symptoms and a CLE test performed before and after the operation. <b>Preliminary Results:</b> Postoperatively, 39/43 patients reported improvements of symptoms, 41/43 had a lower CLE-score, all but 3 had improvement at the supraglottic level, and 21/43 had normal laryngeal inlet at maximum exercise (i.e. a CLE-score of 0 or 1). Complications were experienced by 2/43. <b>Conclusion:</b> Supraglottoplasty improve symptoms in patients with supraglottic EILO, and appears as a safe and efficient treatment in highly selected severe cases.