gebhart/patrepeval huggingface dataset:
Basic emotions, relations among emotions, and emotion-cognition relations. (1992)

From the cognitive theory perspective that emotions are cognition dependent and contain cognitive components, Ortony and Turner (1990) questioned the validity of the concept of basic emotions. They argued that the so-called basic emotions were neither psychologically or biologically "primitive" nor "irreducible building blocks" for generating the "great variety of emotional experiences." In the biosocial theory tradition, researchers have identified multiple noncognitive activators of emotion and demonstrated the usefulness of defining the essential components of emotion as phenomena that do not require cognitive mediators or constituents. In this framework, emotions are seen as basic because their biological and social functions are essential in evolution and adaptation. Particular emotions are called basic because they are assumed to have innate neural substrates, innate and universal expressions, and unique feeling-motivational states. The great variety of emotional experiences is explained as a function of emotion-cognition interactions that result in affective-cognitive structures.
ZERODUR stability in space environments (2021)

Recent comprehensive measurements of ZERODUR<sup>&reg;</sup>’s response to realistic levels of ionizing radiation will be reported. This will compliment an update of ZERODUR<sup>&reg;</sup>’s “history in space”[1] as implemented in both space agencies in Europe and in the United States. Specific recommendations for use of ZERODUR<sup>&reg;</sup> in various orbit environments will be suggested.
Mobile Carrier Choice Modeling under Competitive Conditions (2011)

This paper presents a mobile-carrier choice modeling to analyze customer preference and understand customer choice behavior in the mobile phone market. Due to severe competitive conditions, there are a few differences among mobile phone services provided by mobile-carriers. We propose a new mobile-carrier choice modeling considering incentive factors and restrictive factors as decision-making factors. Web survey is carried out to obtain the sample data for this model. We show the model estimated by using the survey data to analyze mobile-carrier choice behavior.
Documentation of idiotypic cascade after Lym-1 radioimmunotherapy in a patient with non-Hodgkin's lymphoma: basis for extended survival? (2003)

This study offers direct evidence for initiation of a multilevel idiotypic cascade in a patient undergoing passive monoclonal antibody therapy for NHL. The patient's prolonged disease-free survival may, thus, be understood in the context of the generation of endogenous, self-perpetuating tumor-specific antibodies.
NMR Studies of Protein–RNA Interactions (2011)

This chapter describes the preparation of NMR quantities of RNA purified to single-nucleotide resolution for protein–RNA interaction studies. The protocol is easily modified to make nucleotide-specific isotopically labeled RNAs or uniformly labeled RNA fragments for ligation to generate segmentally labeled RNAs.
The enigma of arsenic carcinogenesis: role of metabolism (1999)

Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic is associated with tumors of the lung, skin, bladder, and liver. While it is known to be a human carcinogen, carcinogenesis in laboratory animals by this metalloid has never been convincingly demonstrated. Therefore, no animal models exist for studying molecular mechanisms of arsenic carcinogenesis. The apparent human sensitivity, combined with our incomplete understanding about mechanisms of carcinogenic action, create important public health concerns and challenges in risk assessment, which could be met by understanding the role of metabolism in arsenic toxicity and carcinogenesis. This symposium summary covers three critical major areas involving arsenic metabolism: its biodiversity, the role of arsenic metabolism in molecular mechanisms of carcinogenesis, and the impact of arsenic metabolism on human risk assessment. In mammals, arsenic is metabolized to mono- and dimethylated species by methyltransferase enzymes in reactions that require S-adenosyl-methionine (SAM) as the methyl donating cofactor. A remarkable species diversity in arsenic methyltransferase activity may account for the wide variability in sensitivity of humans and animals to arsenic toxicity. Arsenic interferes with DNA methyltransferases, resulting in inactivation of tumor suppressor genes through DNA hypermethylation. Other studies suggest that arsenic-induced malignant transformation is linked to DNA hypomethylation subsequent to depletion of SAM, which results in aberrant gene activation, including oncogenes. Urinary profiles of arsenic metabolites may be a valuable tool for assessing human susceptibility to arsenic carcinogenesis. While controversial, the idea that unique arsenic metabolic properties may explain the apparent non-linear threshold response for arsenic carcinogenesis in humans. In order to address these outstanding issues, further efforts are required to identify an appropriate animal model to elucidate carcinogenic mechanisms of action, and to define dose-response relationships.
Recovery and purification of nickel-63 from HFIR-irradiated targets (1993)

The production of large quantities of high-specific-activity [sup 63]Ni (>10 Ci/g) requires both a highly enriched [sup 62]Ni target and a long irradiation period at high neutron flux. Trace impurities in the nickel and associated target materials are also activated and account for a significant fraction of the discharged activity and essentially all of the gamma activity. While most of these undesirable activation products can be removed as chloride complexes during anion exchange, chromium, present at [sup 51]Cr, and scandium, present as [sup 46]Sc, are exceptions and require additional processing to achieve the desired purity. Optimized flowsheets are discussed based upon the current development and production experience.
In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells (2013)

Aggregation of α-synuclein (αSyn) in neurons produces the hallmark cytopathology of Parkinson disease and related synucleinopathies. Since its discovery, αSyn has been thought to exist normally in cells as an unfolded monomer. We recently reported that αSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicles more avidly than unfolded recombinant monomers (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) Nature 477, 107-110). However, a subsequent study again concluded that cellular αSyn is an unfolded monomer (Fauvet, B., Mbefo, M. K., Fares, M. B., Desobry, C., Michael, S., Ardah, M. T., Tsika, E., Coune, P., Prudent, M., Lion, N., Eliezer, D., Moore, D. J., Schneider, B., Aebischer, P., El-Agnaf, O. M., Masliah, E., and Lashuel, H. A. (2012) J. Biol. Chem. 287, 15345-15364). Here we describe a simple in vivo cross-linking method that reveals a major ~60-kDa form of endogenous αSyn (monomer, 14.5 kDa) in intact cells and smaller amounts of ~80- and ~100-kDa forms with the same isoelectric point as the 60-kDa species. Controls indicate that the apparent 60-kDa tetramer exists normally and does not arise from pathological aggregation. The pattern of a major 60-kDa and minor 80- and 100-kDa species plus variable amounts of free monomers occurs endogenously in primary neurons and erythroid cells as well as neuroblastoma cells overexpressing αSyn. A similar pattern occurs for the homologue, β-synuclein, which does not undergo pathogenic aggregation. Cell lysis destabilizes the apparent 60-kDa tetramer, leaving mostly free monomers and some 80-kDa oligomer. However, lysis at high protein concentrations allows partial recovery of the 60-kDa tetramer. Together with our prior findings, these data suggest that endogenous αSyn exists principally as a 60-kDa tetramer in living cells but is lysis-sensitive, making the study of natural αSyn challenging outside of intact cells.
RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment (2018)

M2-polarized macrophages have been shown to adapt their 3D migration mode to physical properties of surrounding extracellular matrix. They migrate in the integrin-mediated adhesion and proteolytic activity-dependent "mesenchymal" mode in stiff matrices and in the integrin and protease-independent "amoeboid" mode in low density, porous environments. To find out what impact the switching between the migration modes has on expression of both protein-coding and non-coding genes we employed RNA sequencing of total RNA depleted of ribosomal RNA isolated from macrophages migrating in either mode in 3D collagens. Differentially expressed genes from both categories have been detected and the changes in expression of selected genes were further validated with RT-qPCR. The acquired data will facilitate better understanding of how mechanical properties of tissue microenvironment reflect in macrophage immune function and how the transitions between mesenchymal and amoeboid migratory modes are regulated at the gene expression level.
Field Synergy Analysis and Optimization of the Thermal Behavior of Lithium Ion Battery Packs (2017)

In this study, a three dimensional (3D) modeling has been built for a lithium ion battery pack using the field synergy principle to obtain a better thermal distribution. In the model, the thermal behavior of the battery pack was studied by reducing the maximum temperature, improving the temperature uniformity and considering the difference between the maximum and maximum temperature of the battery pack. The method is further verified by simulation results based on different environmental temperatures and discharge rates. The thermal behavior model demonstrates that the design and cooling policy of the battery pack is crucial for optimizing the air-outlet patterns of electric vehicle power cabins.
Arrangement Computation for Planar Algebraic Curves (2011)

We present a new certified and complete algorithm to compute arrangements of real planar algebraic curves. Our algorithm provides a geometric-topological analysis of the decomposition of the plane induced by a finite number of algebraic curves in terms of a cylindrical algebraic decomposition of the plane. Compared to previous approaches, we improve in two main aspects: Firstly, we significantly reduce the amount of exact operations, that is, our algorithms only uses resultant and gcd as purely symbolic operations. Secondly, we introduce a new hybrid method in the lifting step of our algorithm which combines the usage of a certified numerical complex root solver and information derived from the resultant computation. Additionally, we never consider any coordinate transformation and the output is also given with respect to the initial coordinate system. We implemented our algorithm as a prototypical package of the C++-library CGAL. Our implementation exploits graphics hardware to expedite the resultant and gcd computation. We also compared our implementation with the current reference implementation, that is, CGAL's curve analysis and arrangement for algebraic curves. For various series of challenging instances, our experiments show that the new implementation outperforms the existing one.
Fast and adaptive blind audio source separation using recursive Levenberg-Marquardt synchrosqueezing (2018)

International audience
Genetic Variation at the Chromosome 16 Chemokine Gene Cluster: Development of a Strategy for Association Studies in Complex Disease (2003)

The chemokine gene cluster [CCL22, CX3CL1, CCL17] (previously known as [SCYA22, SCYD1, SCYA17]) is a candidate locus for one of the susceptibility genes for inflammatory bowel disease that are located in the peri-centromeric region of chromosome 16. Screening for sequence variation at this locus led to the detection of 14 single nucleotide polymorphisms (SNPs). An efficient experimental and computational approach was developed to estimate allele frequencies and pairwise linkage disequilibrium relationships between SNPs at this locus, and to test them for association with inflammatory bowel disease. The 12 common SNPs were assigned to 5 distinct linkage disequilibrium groups. Genotyping of one SNP from each linkage disequilibrium group in a large cohort of families with inflammatory bowel disease did not provide convincing evidence of association with either Crohn's disease or ulcerative colitis. We describe an efficient experimental design from SNP screening to association testing. This strategy can be used to test candidate genes for involvement in susceptibility to complex disease.
“This Is the Final Jump,” I Respond. Why, Why Do I Utter Those Words? (2020)

Since the dawn of time, humans have used stories to pass down knowledge and wisdom, make sense of situations, and for pure enjoyment. Stories, when delivered effectively and with appropriate emotion, have the capacity to connect the storyteller and the listener. Stories can provide meaning, evoke cognitive and behavioral change, and problem-solve. Although many domains of healthcare consider storytelling to be an effective intervention strategy with patients, it has yet to become a popular part of applied sport psychology practice with injured athletes. We all have stories to tell – you, me, we, they. This chapter will apply the concept of storytelling within applied sport psychology practice; specifically, in the context of sport injury rehabilitation. It will define storytelling, describe different types of stories, elaborate on the potential outcomes of using storytelling in applied sport psychology consultancy with injured athlete, and touch on the intricacies of effective storytelling. The chapter concludes with some critical questions encouraging the reader to critically think about the role of storytelling in sport injury rehabilitation.
Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy (2014)

Dual antiplatelet therapy with aspirin and a P2Y12 antagonist is widely prescribed for the prevention of thrombotic events in patients with an acute coronary syndrome or undergoing percutaneous coronary intervention (PCI). It is recognised that there is inter-individual variation in the antiplatelet effects of both drugs. Recent data also suggest that P2Y12 antagonists can affect the response to aspirin. A direct indicator of the effect of aspirin on platelets is their ability to generate thromboxane, which if measured as the difference between the level of thromboxane B2 in serum and plasma ([TxB2]S-P) avoids the confounding effect of endogenous TxB2 production from other cells. We therefore analysed [TxB2]S-P as a measure of aspirin response in a group of 123 patients undergoing elective PCI before and after the introduction of clopidogrel. In a subgroup of 40 patients taking aspirin alone, we compared [TxB2]S-P and VerifyNow Aspirin for the assessment of aspirin response. There was a wide variation in plasma and serum TxB2 concentrations both before and after clopidogrel therapy but only 3.5% of patients had residual serum concentration of TxB2 > 10 ng/ml. There was a strong correlation between the pre and post clopidogrel levels of TxB2 (r ≥ 0.78; p = 0.001) and no significant difference in [TxB2]S-P. There was no correlation between the magnitude of response to clopidogrel response and the generation of thromboxane B2. Correlation between [TxB2]S-P and VerifyNow Aspirin was poor. We conclude that the use of a P2Y12 antagonist does not influence the effect of aspirin on the ability of platelets to generate thromboxane. Therefore, measurement of TxB2 levels in serum, after subtracting the contribution from plasma, provides a measure of the response to aspirin in patients taking dual antiplatelet therapy.
Erratum: “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets” [Rev. Sci. Instrum. 80, 054302 (2009)] (2010)

First Page
Efficient and Optimized Methods for Alleviating the Impacts of IR-Drop and Fault in RRAM Based Neural Computing Systems (2021)

Resistive switching random access memory (RRAM) shows its potential to be a promising candidate as the basic in-memory computing unit for deep neural networks (DNN) accelerator design due to its non-volatile, low power, and small footprint properties. The RRAM based crossbar array (RRAM CBA) is usually employed to accelerate DNN because of its intrinsic characteristic of executing multiplication-and-accumulation (MAC) operation according to Kirchhoffs' law. However, some major non-ideal effects including IR-drop and Stuck-at-Faults (SAF) in real RRAM CBA are typically ignored in the DNN accelerator design because of the considerations of training speed and design closure. Such non-ideal effects will conduct the variations of output column current and voltage and further cause serious degradation in computing accuracy. Thus, direct mapping from the weights of DNN model without considering the IR-drop and SAF to RRAM CBA is unrealistic. In this work, two efficient and optimized methods including adding additional tunable RRAM row and Trans-impedance amplifier (TIA) based RRAM are proposed to recover the computation accuracy with a view to reducing variation of the output column current of the RRAM CBA and output voltage of the TIA in each column respectively. The two optimized methods are evaluated in different sizes of RRAM CBA and different resistance levels of RRAM cell. The simulation results show that the two optimized methods can further suppress the degradation of computing accuracy induced by IR-drop and SAF for LeNet-5 with the MNIST dataset and VGG16 with the CIFAR-10 dataset.
A Review of AC-DC Converters with Injection Circuits - Part II (2018)

AC-DC three-phase converters are very well known for having enhanced power quality with unity displacement power factor, low total harmonic pollution in the AC side, and controllable DC output with unidirectional or bidirectional power flow. The second part of this paper presents a review of several three-phase AC-DC converters with active current injection circuits, including some hybrid configurations, detailing their respective topologies and characteristics.
Variable-time-delay optical coherent transient signal processing (1999)

A technique is proposed and experimentally demonstrated that achieves simultaneous optical pattern waveform storage and programmable time delay for continuous real-time signal processing by use of optical coherent transient technology. We achieve variable-time-delay and broadband signal processing by frequency shifting of two chirped programming pulses, the chirp rate of one being twice that of the other, without using brief reference pulses and without changing the timing of the programming sequence. We demonstrate the technique experimentally in Tm(3+): YAG at 5 K for 40-MHz chirps by performing temporal signal convolution with true-time delays that vary over a 250-ns range.
Clinical Investigation of Antiarrhythmic Devices: A Statement for Healthcare Professionals From a Joint Task Force of the North American Society of Pacing and Electrophysiology, the American College of Cardiology, the American Heart Association, and the Working Groups on Arrhythmias and Cardiac Pacing of the European Society of Cardiology (1995)

The goal of radiofrequency catheter ablation and the criterion for efficacy is the elimination of arrhythmogenic myocardium. The application of radiofrequency current in the heart clearly results in lower morbidity and mortality rates than thoracic and cardiac surgical procedures in general, and comparisons of therapy with radiofrequency catheter ablation and therapy with thoracic and cardiac surgical procedures in randomized clinical trials are unwarranted. Trials of radiofrequency catheter ablation versus medical or implantable cardioverter defibrillator therapy may be indicated in certain conditions, such as ventricular tachycardia associated with coronary artery disease. Randomized trials are recommended for new and radical departures in technology that aim to accomplish the same goals as radiofrequency catheter ablation. Surveillance using registries and/or databases is necessary in the assessment of long-term safety and efficacy.
Site occupancy and photoluminescence of Sm^3+ in KSr_4(BO_3)_3:Sm^3+ phosphors (2014)

The phosphors of Sm3+ activated KSr4(BO3)3 are synthesized through a solid state reaction. The site occupancy of Sm3+ in KSr4(BO3)3:Sm3+ was studied by Rietveld analysis of the X-ray powder diffraction patterns. Sm3+ ions are inclined to occupy 8c (Sr2) and 4a (Sr3) sites in the structure of KSr4(BO3)3 according to the refinement results. The luminescence properties of Sm3+ activated KSr4(BO3)3 have been investigated and strong reddish orange emitting color is found. The phenomenon of concentration quenching can be observed with the increasing of Sm3+ concentration. The nonradiative concentration quenching among two nearest Sm3+ centers occurs via electric multipolar interactions based on the Dexter theory. Fluorescence lifetime of KSr4(BO3)3:Sm3+ is 0.69, 0.74, 0.70, and 0.69 ms for the transition of 4G5/2 to 6HJ (J = 5/2, 7/2, 9/2, 11/2) respectively and the critical distance is 17.6 A.
Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones. (1993)

The 43-kD growth-associated protein (GAP-43) is a major protein kinase C (PKC) substrate of growing axons, and of developing nerve terminals and glial cells. It is a highly hydrophilic protein associated with the cortical cytoskeleton and membranes. In neurons it is rapidly transported from the cell body to growth cones and nerve terminals, where it accumulates. To define the role of GAP-43 in neurite outgrowth, we analyzed neurite regeneration in cultured dorsal root ganglia (DRG) neurons that had been depleted of GAP-43 with any of three nonoverlapping antisense oligonucleotides. The GAP-43 depletion procedure was specific for this protein and an antisense oligonucleotide to the related PKC substrate MARCKS did not detectably affect GAP-43 immunoreactivity. We report that neurite outgrowth and morphology depended on the levels of GAP-43 in the neurons in a substrate-specific manner. When grown on a laminin substratum, GAP-43-depleted neurons extended longer, thinner and less branched neurites with strikingly smaller growth cones than their GAP-43-expressing counterparts. In contrast, suppression of GAP-43 expression prevented growth cone and neurite formation when DRG neurons were plated on poly-L-ornithine. These findings indicate that GAP-43 plays an important role in growth cone formation and neurite outgrowth. It may be involved in the potentiation of growth cone responses to external signals affecting process formation and guidance.
Design and fabrication of the cryostat for the floating coil of the Levitated Dipole Experiment (LDX) (2000)

The Levitated Dipole Experiment (LDX) is a new, innovative magnetic confinement fusion experiment being designed and installed in collaboration with Columbia University at the Massachusetts Institute of Technology (MIT). The primary objective of the experiment is to investigate the possibility of steady-state, high-beta plasma confinement with near classical transport. The main component of the experiment is a levitated cryostat with a 5.7 T Nb/sub 3/Sn superconducting magnet, housed in an Inconel high pressure helium vessel. The pressure vessel is surrounded by a large thermal mass radiation shield and an outer vacuum shell, all of which are magnetically levitated inside a much larger vacuum chamber. The cryostat, now under construction is described in this paper. The cryostat keeps the magnet temperature between 5 and 10 K during 8 hours of levitated operation.