gebhart/patrepeval huggingface dataset:
Loss of the controlled localization of growth stage‐specific cell‐wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor (2007)

Members of the family of SsgA-like proteins (SALPs) are found exclusively in sporulating actinomycetes, and SsgA itself activates sporulation-specific cell division. We previously showed that SALPs play a chaperonin-like role in supporting the function of enzymes involved in peptidoglycan maintenance (PBPs and autolysins). Here we show that SsgA localizes dynamically during development, and most likely marks the sites where changes in local cell-wall morphogenesis are required, in particular septum formation and germination. In sporogenic aerial hyphae, SsgA initially localizes as strong foci to the growing tips, followed by distribution as closely spaced foci in a pattern similar to an early stage of FtsZ assembly. Spore septa formed in these hyphae colocalize with single SsgA-GFP foci, and when the maturing spores are separated, these foci are distributed symmetrically, resulting in two foci per mature spore. Evidence is provided that SsgA also controls the correct localization of germination sites. Transcriptome analysis revealed that expression of around 300 genes was significantly altered in mutants in ssgA and its regulatory gene ssgR. The list includes surprisingly many known developmental genes, most of which were upregulated, highlighting SsgA as a key player in the control of Streptomyces development.
White light oblique incidence reflectometer for measuring absorption and reduced scattering spectra of tissue-like turbid media (1998)

We designed a quick and inexpensive system for spectral measurements of optical properties including absorption coefficient and reduced scattering coefficient. The system was based on oblique incidence reflectometry.[1] A broad band light source was coupled into an optic fiber to deliver light obliquely to turbid media. Nine detection optic fibers were used to collect the diffuse reflectance as a function of source-detector distance. The relative diffuse reflectance profile was used to deduce the absorption and reduced scattering spectra. The system was able to acquire data in a wavelength range of 256 nm within a fraction of a second.
N2-guanyl and N6-adenyl arylation of chicken erythrocyte DNA by the ultimate carcinogen of 4-nitroquinoline 1-oxide. (1986)

Great quantities of chicken erythrocyte DNA with high levels of modification were obtained in vitro by reaction with 4-acetoxyaminoquinoline 1-oxide, a model ultimate carcinogen of 4-nitroquinoline 1-oxide. After enzymatic hydrolysis of the modified DNA, the three main adducts were separated and isolated by semipreparative high performance liquid chromatography. These three adducts were already characterized in vivo and in vitro in our previous work (S. Galiègue-Zouitina et al., Cancer Res., 45: 520-525, 1985). The structure of one of them was previously identified as N-(deoxyguanosin-8-yl)-4-aminoquinoline 1-oxide (B. Bailleul et al., Cancer Res., 41: 4559-4565, 1981). In this paper we have identified by mass spectroscopy and nuclear magnetic resonance the structures of the two other main adducts as 3-(deoxyguanosin-N2-yl)-4-aminoquinoline 1-oxide and 3-(deoxyadenosin-N6-yl)-4-aminoquinoline 1-oxide, respectively.
The pharmacological treatment of Meni�re's disease (1996)

The management of Menière's disease often provides a formidable clinical challenge largely because its precise aetiology is unknown. There is no known 'cure' once the condition is established, but drugs may be helpful in treating both the acute attacks of vertigo, and in more long-term management, particularly in the earlier fluctuant stage. These remedies are largely symptomatic and there are few if any properly controlled studies of their efficacy. Suppressant drugs may act centrally at neurotransmitter sites, or peripherally on the labyrinth. Conventional diuretics and osmotically acting agents have been given to reduce the endolymph fluid volume. Histamine analogues directly reduce inner ear fluid pressure mainly by increasing the cochlear blood flow, and are probably the treatment of choice. Otovestibulotoxic drugs given systemically to cause chemical labyrinthine ablation are frequently effective in abolishing attacks of vertigo but often resulted in disabling oscillopsia and ataxia. There is now evidence that local administration by intratympanic injection may well be more efficacious resulting in selective partial end organ ablation. To date innovative immune modifying regimes have not proved helpful.
Nanoscale Thermal Processing Using a Heated Atomic Force Microscope Tip (2007)

This dissertation aims to advance the current state of use of silicon atomic force microscope (AFM) cantilevers with integrated heaters. To this end, the research consists of two primary thrusts - demonstrating new applications for the cantilevers, and advancing the current state of understanding of their thermal and mechanical behavior to enable further applications. Among new applications, two are described. In the first application, the cantilevers are used for nanoscale material deposition, using heat to modulate the delivery of material from the nanoscale tip. In the second application, the cantilever performs thermal analysis with nanoscale spatial resolution, enabling thermal characterization of near surface and composite interphase regions that cannot be measured with bulk analysis techniques. The second thrust of the research seeks to address fundamental questions concerning the precision use of heated cantilevers. Efforts to this end include characterizing the mechanical, electrical, and thermal behavior of the cantilevers, and optimizing calibration methodology. A technique is developed for calibrating the cantilever spring constant while operating at elevated temperature. Finally, an analytical model is developed for the heat flow in the cantilever tip and relevant dimensionless numbers that govern the relative importance of the various components of the thermal environment are identified. The dimensionless numbers permit exploration of the sensitivity of the tip-substrate interface temperature to the environmental conditions.
Old Age and Myocardial Injury in ST-Segment Elevation Myocardial Infarction (2021)

Despite appropriate coronary revascularization, old age was associated with greater extent of myocardial injury in STEMI patients.
Characterisation of MS phenotypes across the age span using a novel data set integrating 34 clinical trials (NO.MS cohort): Age is a key contributor to presentation (2021)

NO.MS will illuminate questions related to MS characterisation, progression and prognosis. Age modulates relapse frequency and, thus, the phenotypic presentation of MS. Disease worsening across all phenotypes is mediated by age and appears to some extent be independent from new focal inflammatory activity.
GAC-Amended UASB Reactor for the Stable Treatment of Toxic Textile Wastewater (1998)

Abstract A feasibility study was carried out in the laboratory for the sequential anaerobic/aerobic treatment of textile wastewater. The process units consisted of an anaerobic UASB (upflow anaerobic sludge blanket) reactor and a SCAS (semi-continuous activated sludge) reactor. A contact-sorption layer with GAC (granular activated carbon) was provided at the bottom of the conventional UASB reactor. The raw textile wastewater first passed through the GAC bed and then through the sludge bed. By means of the GAC bed, the top-layer granular sludge was protected from toxicants. Biological regeneration of GAC, which was enhanced via a recycle flow, was demonstrated. The combined GAC-UASB and SCAS treatments allowed a stable performance and a COD (chemical oxygen demand) and colour removal of 98 and 95 %, respectively. Keywords: Activated sludgecolour removalgranular activated carbontextile wastewatertoxic wastewaterUASB reactor
Dielectric performance of high permitivity nanocomposites: impact of polystyrene grafting on BaTiO3 and TiO2 (2016)

Polymer nanocomposites are a promising concept to improve energy storage density of capacitors, but realizing their hypothetical gains has proved challenging. The introduction of high permittivity fillers often leads to reduction in breakdown strength due to field exclusion, which intensifies the applied electric field within the polymer matrix near nanoparticle interfaces. This has prompted research in developing new nanoparticle functionalization chemistries and processing concepts to maximize particle separation. Herein, we compare the dielectric performance of blended nanocomposites to matrix free assemblies of hairy (polymer grafted) nanoparticles (HNPs) that exhibit comparable overall morphology. The dielectric breakdown strength of polystyrene grafted BaTiO3 (PS@BaTiO3) systems was over 40% greater than a blended nanocomposite with similar loading (~25% v/v BaTiO3). Hairy nanoparticles with TiO2 cores followed similar trends in breakdown strength as a function of inorganic loading up to 40% v/v. Dielectric loss for PS@BaTiO3 HNPs was 2–5 times lower than analogous blended films for a wide frequency spectrum (1 Hz to 100 kHz). For content above 7% v/v, grafting the polymer chains to the BaTiO3 significantly improved energy storage efficiency. Overall this study indicates that polymer grafting improves capacitor performance relative to direct blending in likely two ways: (1) by mitigating interfacial transport to lower dielectric loss, irrespective of the dielectric contrast between matrix and nanoparticle, and (2) by restricting particle–particle hot-spots by establishing a finite minimum particle separation when the dielectric contrast between matrix and nanoparticle is large.
Near-Optimal Evasion of Convex-Inducing Classifiers (2010)

Classifiers are often used to detect miscreant activities. We study how an adversary can efficiently query a classifier to elicit information that allows the adversary to evade detection at near-minimal cost. We generalize results of Lowd and Meek (2005) to convex-inducing classifiers. We present algorithms that construct undetected instances of near-minimal cost using only polynomially many queries in the dimension of the space and without reverse engineering the decision boundary.
Multidimensional trellis coded phase modulation using a multilevel concatenation approach. I. Code design (1997)

The first part of this paper presents a simple and systematic technique for constructing multidimensional M-ary phase shift keying (MPSK) trellis coded modulation (TCM) codes. The construction is based on a multilevel concatenation approach. In which binary convolutional codes with good free branch distances are used as the outer codes and block MPSK modulation codes are used as the inner codes (or the signal spaces). Conditions on phase invariance of these codes are derived and a multistage decoding scheme for these codes is proposed. The proposed technique can be used to construct good codes for both the additive white Gaussian noise (AWGN) and fading channels as is shown in the second part of this paper.
Electrical behavior of 4H-SiC metal-oxide-semiconductor structures with Al2O3 as gate dielectric (2005)

The electrical properties of Al2O3 as a gate dielectric in metal-oxide-semiconductor structures based on n- and p-type 4H-SiC grown by sublimation method have been investigated and compared to the properties of similar structures utilizing SiO2. The electrically active defects in the structures are studied by capacitance–voltage (C–V) and current–voltage (I–V) methods. The results show that the type as well as spatial and energy distributions of defects in Al2O3∕SiC and SiO2∕SiC samples are different. The structures with Al2O3 on p-type 4H-SiC demonstrate much better electrical characteristics than the p-type 4H-SiC∕SiO2 structures. It is demonstrated that the conduction process in the former is governed by Fowler–Nordheim electron tunneling from the Al gate whereas in the latter the hole tunneling from SiC is the more probable process. This difference combined with the higher defect density in p-type SiC∕SiO2 structures defines the higher leakage currents compared to the structures utilizing Al2O3.
Validation of Virus Inactivation by Heat Treatment in the Manufacture of Diaspqun Crosslinksd Hemoglobin (1992)

Diaspirin crosslinked hemoglobin (DCLHb), a hemoglobin based oxygen carrying solution prepared from outdated human blood, is subjected to a heat treatment step to inactivate viruses in our manufacturing process. To validate the efficacy of this inactivation, we have simulated the heat treatment procedure at a reduced scale using hemoglobin solution spiked with representative viruses. Human Immuno-deficiency Virus (HIV), Cytomegalovirus (CMV), and Duck Hepatitis B Virus (DHBV) were used in this validation. Inoculation with concentrated virus was performed just prior to the heat treatment to determine the effect of that specific process step. Samples were taken before, during, and after heat treatment and assayed for virus titer in an attempt to assess the rate as well as the extent of virus inactivation. CMV was analyzed in a plaque assay using MRC-5 indicator cells. The titer was reduced from 3.3 x 10(6) plaque forming units (PFU) per mL to less than 5 x 10(1) PFU/mL (detection limit) within 30 minutes. DHBV was analyzed by inoculation of serially diluted samples into Pekin ducklings, followed at intervals by screening sera for DHBV DNA by dot blot hybridization. The titer was reduced from 5.0 x 10(6) duck infectious units (DIU) per mL to less than 5 x 10(0) DIU/mL (detection limit) within 1 hour. HIV titers were determined through an ELISA assay for p24 antigen present in peripheral blood lymphocyte cocultivation supernatants. The titer was reduced from 2.0 x 10(4) infectious units (IU) per mL to less than 2 x 10(0) IU/mL (detection limit) within 1 hour. These data indicate that high titers of these blood borne viruses are rapidly inactivated by this heat treatment process.
ChemInform Abstract: N‐ACETYL‐N‐OXO‐1,4‐BENZOQUINONE IMINE, OBSERVATION OF AN ACYL NITRONE (1985)

Abstract Die Ursache für Lebernecrose bei der Einnahme hoher Dosen des Analgeticums Paracetamol (I) wird auf die Bildung des N‐Acetyl‐l ,4‐benzochinonimins (III) als Metabolit zurückgeführt, der mit Makromolekülen der Zellen reagiert.
<title>Chemical and electronic structure of conjugated polymer/metal interfaces relevant in LED devices</title> (1995)

The electronic structure of conjugated polymers of current interest in the developemnt of novel organic light-emitting diodes, poly(p-phenylenevinylene) and its derivatives, has been studied experimentally by ultraviolet photoelectron spectroscopy and x-ray photoelectron spectroscopy as well as theoretically using quantum-chemical calculations. The focus of this work is on the (pi) -electronic structure near the Fermi level, which is of prime importance in the phenomena of charge carrier injection, interface formation, and light emission.
PREPARATION AND PROPERTIES OF LIGNIN-EPOXY RESIN COMPOSITE (2012)

A cross-linked biomass-polymer composite with a lignin content of up to 60% was prepared by blending lignin with an epoxy resin and polyamine using a hot press molding process. The characteristics of the curing reaction of lignin with epoxy resin were studied using DSC and FTIR analysis. The effect of molding temperature and molding pressure on the mechanical properties and microstructure of the lignin/epoxy resin composite was also studied by SEM, DMA, and TG analyses. The results showed that the epoxy resin can be cured by lignin, and the curing temperature for the blends can be reduced by the introduction of a polyamine cure agent. The properties of the composite, such as bending strength, impact strength, glass-transition temperature, and thermal stability, were evidently influenced by the molding process. A good interfacial combination was formed between lignin and epoxy resin. Increasing the molding temperature and pressure proved beneficial to achieve a better interfacial combination for the composite, and the degree of ductile fracture was increased in the fracture surface of the composite.
Fraud detection in communication networks using neural and probabilistic methods (2002)

Fraud detection refers to the attempt to detect illegitimate usage of a communication network. Three methods to detect fraud are presented. Firstly, a feed-forward neural network based on supervised learning is used to learn a discriminative function to classify subscribers using summary statistics. Secondly, a Gaussian mixture model is used to model the probability density of subscribers' past behavior so that the probability of current behavior can be calculated to detect any abnormalities from the past behavior. Lastly, Bayesian networks are used to describe the statistics of a particular user and the statistics of different fraud scenarios. The Bayesian networks can be used to infer the probability of fraud given the subscribers' behavior. The data features are derived from toll tickets. The experiments show that the methods detect over 85% of the fraudsters in our testing set without causing false alarms.
Nuclear and nucleolar ultrastructure of Sézary cells. (1977)

Sézary cells were studied in the peripheral blood and characteristic skin lesions of the Sézary syndrome and mycosis fungoides by transmission electron microscopy to obtain more information on their nuclear and nucleolar ultrastructure. Sézary cells contain nucleoli with nucleolonemas or ring-shaped nucleoli similar to those of lymphoblasts and mature lymphocytes. "Maturation asynchrony" of the nucleolus and cytoplasm was evident in some cells that contain large numbers of ribosomes and ring-shaped nucleoli and in other cells that contain nucleoi with nucleolonemas and few ribosomes. The maturation asynchrony of the nucleolus and the cytoplasm, the presence of mitochondrion-like inclusion bodies in the nucleus, and fusion of mitochondria with the nucleus in Sézary cells are ultrastructural abnormalities of this neoplastic lymphocytic variant. The presence of the intranuclear "mitochondrion-like" inclusion body and nuclear rodlets in Sézary cells were exceptional findings.
First order parametric instability of quasi-surface spin waves in ferromagnetic films (1991)

A theory is presented for the first-order (three-wave) parametric instability of a quasi-surface spin wave propagating in a tangentially magnetized ferromagnetic film. It is taken into account that the propagating quasi-surface spin wave is excited by the localized pumping magnetic field (e.g. the field of a microstrip antenna), and the threshold value of this field is calculated. Theoretical results are compared to the results of experiments performed on yttrium-iron-garnet films.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 19162: Dual Mechanisms of Cardiac Sodium Channel Inhibition by Wnt/β-catenin Signaling (2017)

Background and Hypothesis: Wnt/β-catenin signaling is activated in arrhythmogenic heart disease. We have recently demonstrated that activation of Wnt/β-catenin signaling leads to reductions in cardiac Na+ current (INa), a condition that promotes arrhythmias. But the underlying mechanisms are not known. Here, we report evidence that support two separate mechanisms for INa inhibition: Wnt/β-catenin leads to transcriptional activation of Tbx3, which suppresses expression of Scn5a (the cardiac Na+ channel α subunit gene); in addition, Wnt/β-catenin directly inhibits Scn5a transcription. Methods and Results: 1) activation of Wnt/β-catenin signaling in neonatal rat ventricular myocytes (NRVMs) by exposure to Wnt3a protein led to reductions (p<0.05) in both Nav1.5 protein and Scn5a mRNA levels; 2) qRT-PCR screening of a group of transcription factors that are known to regulate Scn5a expression identified Tbx3, a transcriptional suppressor, as a gene upregulated by Wnt/β-catenin; bioinformatics analysis of the Tb...
A synergistic {Cu2-W12O40} catalyst with high conversion for homo-coupling of terminal alkynes (2022)

The 2D {[Cu 2 (OAc) 4 ] 2 (W 12 O 40 )} n network with unique Cu-POM synergistic cooperation to lead alkyne C–H activation is a super efficient catalyst with high conversion in homo-coupling of terminal alkynes.
The predominant cultivable dental plaque flora of beagle dogs with gingivitis (1980)

The predominant dental plaque flora of 15 female beagle dogs (1,3 and 6 year old) with naturally developed gingivitis was studied using a continuous anaerobic culturing technique. Supra‐ and subgingival plaque samples from the buccal aspect of the upper third premolar were cultured on various growth media and the organisms were partially characterized. The flora in all dogs was composed mostly of anaerobic Gram negative organisms. B. asaccharolyticus (B. melaninogenicus ss. asaccharolyticus) was found in both types of plaques in all animals and decomposed hydrogen peroxide suggesting catalase activity. F. nucleatum was found in higher proportions in the subgingival plaque as compared to B. asaccharolyticus and actinomycetes. Spirochetes were found in 10 of 15 supra‐ and in 1 of 15 subgingival specimens. S. mutans, S. mitior, S. salivarius, Veillonella, Selenomonas or vibrios could not be detected in any of the plaque samples. A combined data analysis showed, that the total viable CFU and the proportions of Gram positive organisms were significantly higher in the supra‐ than the subgingival plaque. Although the proportions of Gram negative bacteria were higher in subgingival plaque, the differences between the two types of plaques excluding F. nucleatum were not significant.
Kinetic study of the curing behavior of bismaleimide modified with diallylbisphenol A (2003)

Abstract The curing kinetics of bismaleimide modified with diallylbisphenol A were investigated for different ratios of 1,1′‐(methylene di‐4,1‐phenylene) bismaleimide and diallylbisphenol A with differential scanning calorimetry. Multiheating‐rate and isothermal methods were used to study the kinetics of the curing process. The results indicated that the activation energy changed with the extent of conversion. The activation energy obtained by the multiheating‐rate method was higher than that obtained by the isothermal method. Two kinetic models (autocatalytic and n th‐order) were successfully used to model the curing process. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 2229–2240, 2003
Stand der Forschung und Technik (2011)

In diesem Kapitel wird der Stand der Forschung und Technik dargestellt und analysiert. Die Grundlage dafür bilden definierte Anforderungen, die die strukturierte Analyse und objektive Bewertung der Literatur ermöglichen und in einem Anforderungskatalog dargestellt werden. Die Analyse des Forschungsstandes gliedert sich analog zur Struktur der Arbeit. Zuerst werden Zugriffskontroll- und Rollenkonzepte diskutiert, um im Anschluss daran die Modellierung von sicheren Systemen und Policies zu analysieren.
The synthesis of some quinazoline derivatives and their biological properties (1983)

Abstract Synthesis of some quinazoline derivatives was carried out with their plant protection capabilities in mind. The syntheses of 17 substances from this group (among them 6 new ones) have been completed. Different substituents have been introduced, first in position 4, then in position 2 and 4 of quinazoline, then two substituents to both rings (e.g. hydroxyl, chlorine, piperidyl, hydrazine, ethanolamine). The above‐mentioned compounds were tested in the first stage from the point of view of their fungicidal, insecticidal and herbicidal activity. One compound (4‐chloroquinazoline) was taken to the second stage of investigations because of its fungicidal activity. It has not qualified, however for further investigations.