gebhart/patrepeval huggingface dataset:
P1‐130: INTEREST IN CSF BIOMARKERS IN THE DIAGNOSIS OF LATE ONSET BV‐FRONTOTEMPORAL LOBAR DEGENERATION (BV‐FTLD) VERSUS ALZHEIMER'S DISEASE (AD) (2014)

Late-onset bv-FTLD (>65 ys) accounts for 3-18% of all bv-FTLD. New clinico-radiological diagnostic criteria for bv-FTLD show low sensibility for late-onset cases, and AD is the main misdiagnosis. The aim of this study is to investigate whether CSF biomarkers could help reach a better diagnosis of late-onset bv-FTLD. We conducted a retrospective study (2007-2013) on clinically diagnosed amnestic AD or bv-FTLD patients with onset after 65 ys and available clinical records and CSF biomarkers; patients with severe psychiatric symptoms and major vascular burden were excluded. We re-classified patients as AD or bv-FTLD according to the revised criteria (McKhann, 2011; Rascovsky, 2011); we then applied the CSF T-Tau/Abeta42 (>1.06) and P-Tau/Abeta42 (>0.2) cut-offs for diagnosis of MA vs FTLD (Bian, 2008; De Souza, 2011) and investigated how they contribute to the final diagnosis. Fifty-seven patients (mean age at onset: 71.5 ys) were included. According to the international criteria initial diagnoses were AD (N=41; 72%), bv-FTLD (N=12; 21%) or “neither AD nor bv-FTLD” (N=4; 7%), classified as follow: probable AD dementia with uninformative (N=5), intermediate-level (N=0), and high-level (N=2) biomarker probability; possible AD dementia with uninformative (N=20) or high-level (N=12) biomarker probability; possible (N=3) or probable (N=9) bv-FTLD; executive AD (possible bv-FTLD with high level biomarker probability of AD) (N=2). According to CSF MA vs FTLD cut-offs the final diagnoses were AD (N=22, 38.5%), FTLD (N=29, 51%) or undetermined (N=6, 10.5%). All probable AD with high biomarker probability were confirmed as AD, whereas 4 out of 5 probable AD with uninformative biomarkers were finally diagnosed as FTLD. Most possible AD with high biomarker probability were confirmed as AD (10/12). In possible AD with uninformative biomarker probability the diagnosis remained AD (7/20), changed to DLFT (9/20), or was undetermined (4/20). All probable and possible bv-DFLT were confirmed. The cases “neither AD nor bv-FTLD” had CSF results compatible with DLFT. Late onset bv-FTLD is possibly under diagnosed. When bv-FTLD criteria are not satisfied, CSF analysis could be an important clue to suggest this alternative diagnosis and to differentiate it from AD. Anatomo-pathological confirmation is required to definitely validate these results.
The importance of energy efficiency in buildings (2006)

Reducing energy demand at source is not only more sustainable in the long term but in many instances may also incur very little cost
Heat Transfer Enhancement in the Heat Sinks for Electronic Cooling Applications (2005)

In a design competition by the mechanical engineering students at Carnegie Mellon University, which was the design of heat sinks for electronic cooling applications, twenty seven heat sinks were designed and tested for thermal performance. A heat sink with three rows of 9, 8, and 9 dimpled rectangular fins (staggered configuration) demonstrated the best performance in the test. This heat sink even had the least total volume (about 25% less than the set value). This paper reports on an effort made to verify and quantify the role of dimples on heat transfer enhancement of the heat sinks. This includes measurements and simulations of the thermal fluid properties of the heat sinks with and without dimples. Results of both the measurements and simulations indicate that dimples do in fact improve heat transfer capability of the heat sinks. Albeit, dimpled fins cause more pressure drop in air along the heat sink. Keeping the total volume of the heat sink and the height of the fins constant and changing the number of the fins and their arrangement show that there exist an optimum number of fins for the best performance of the heat sink. However, this number of fins is different for inline and staggered arrangements. To check the role of the roughness type on the heat transfer behavior of the fins, a heat sink with twenty-seven bumped fins with inline arrangement was also simulated. Results indicated that bumps increase both thermal resistance and pressure drop relative to that of the heat sinks with plain fins.
Marangoni drying: A new extremely clean drying process (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMarangoni drying: A new extremely clean drying processA. F. M. Leenaars, J. A. M. Huethorst, and J. J. Van OekelCite this: Langmuir 1990, 6, 11, 1701–1703Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/la00101a014https://doi.org/10.1021/la00101a014research-articleACS PublicationsRequest reuse permissionsArticle Views1840Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Latest perspectives of orally bioavailable 2,4-diarylaminopyrimidine analogues (DAAPalogues) as anaplastic lymphoma kinase inhibitors: discovery and clinical developments (2018)

The course of anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) therapy has improved impressively. The Food and Drug Administration (FDA) has approved crizotinib (Xalkori, Pfizer) as a first-in-class tyrosine kinase inhibitor (TKI) that demonstrated a substantial objective response rate (ORR) and remarkable progression-free survival (PFS). However, acquired resistance to crizotinib is still a major concern especially as the central nervous system (CNS) remains the most common sites of relapse. To combat disease resistance, limited PFS and poor CNS exposure exhibited by crizotinib (Xalkori, Pfizer) led to the discovery of numerous next generation ALK-TKIs and surprisingly most of them are 2,4-Diarylaminopyrimidine Analogues (DAAPalogues). To date, DAAPalogues have been investigated extensively to display their superior potency against numerous kinase targets especially ALK/ROS1. This review describes hit-to-drug evolution strategies, activity spectra, milestones related to medicinal chemistry discovery efforts and scalable synthetic pathways of clinically emerging DAAPalouges which are either progressing as investigational or preclinical candidates. In addition, the significance of DAAPalogues to treat the patients with ALK<sup>+</sup>-NSCLC in clinical settings has been detailed. This review is beneficial for medicinal chemists and researchers contributing to discovering ALK-TKIs to overcome existing issues related to DAAPalouges in the drug discovery process.
Reactive Methylene Compounds. III. Attempted Syntheses of Cinnolines (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactive Methylene Compounds. III. Attempted Syntheses of CinnolinesH. G. GargCite this: J. Org. Chem. 1962, 27, 3, 1045–1047Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March 1962https://pubs.acs.org/doi/10.1021/jo01050a512https://doi.org/10.1021/jo01050a512research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplemental Figure S1 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes (2023)

&lt;p&gt;A color analogy to illustrate the advantages of spectra variables for modeling. a) Individual observations of color. b) Dimension Reduction (additive color theory), all colors can be represented using 3 quantitative RGB variables. c) Standard-use, hierarchical clustering identifies 3 groups. Each sample is categorized into a group (A, B or C). Subsequent modeling uses one categorical variable. d) Multivariable modeling with quantitative spectra variables, multiple spectra integrated directly into a multivariable analysis. Each uncorrelated variable can be assessed separately for its predictive value for an outcome. This implementation retains higher resolution because the variables are quantitative and retain integrity to the initial data. Note, lower-resolution versions of xB and xG can be achieved using hierarchical groups, but the loss of quantification may lose power. xR cannot be captured by any group ordering and associations for this spectrum would be lost using hierarchical groups. Three dimensions shown for visualization purposes; transcriptome data is likely to harbor a higher number of dimensions.&lt;/p&gt;
A real time patient monitoring system on the World Wide Web. (1996)

World Wide Web (Web) technology has become increasingly popular and successful, because it uses standard communication protocols and Hyper Text Markup Language(HTML), and is supported on multiple platforms. Innovations such as server push, secure socket layer and Java make it possible to use the Web as the basis for creating monitoring systems of dynamic processes. This paper presents a project, whose goal is to develop a Web based Intelligent on-line Monitoring system for Intensive Care Units (IMI). IMI has been tested and evaluated in an intensive care unit since October 1995, and the results are promising. After presenting the motivations of using Web technology, we present the system structure and the functionality of IMI as well as the testing and evaluation results. Security issues are also addressed.
Glucagon-like Peptide-1 (GLP-1), Immediately Prior to Reperfusion, Decreases Neutrophil Activation and Reduces Myocardial Infarct Size in Rodents (2011)

Glucagon-like peptide-1 (GLP-1) is an incretin that has glucoregulatory effects as well as protective effects in a variety of tissues, including the heart. We hypothesized that GLP-1 may have a direct effect on neutrophils (PMNs) after myocardial ischemia, to ameliorate reperfusion injury. Deeply anesthetized Sprague-Dawley rats underwent 30 min of left coronary artery occlusion followed by 120 min of reperfusion. Immediately prior to reperfusion, rats were treated with either GLP-1 (human rGLP-1, 30 pM/kg/min) or PBS as placebo. GLP-1 significantly decreased myocardial infarct size [73.2±11.7% INF/AAR in PBS (n=4) vs. 15.7 ±5.52% INF/AAR in GLP-1-treated animals (n=5), p<0.05], PMN activation in blood in vivo (fMLP-stimulated CD11b surface expression: PBS 2.78±1.14 vs. GLP-1 1.7±0.21, TFI, p<0.05), and accumulation in myocardium (PBS: 6.52±0.31 vs. GLP-1: 4.78±0.90, n=4-6 animals/group, p<0.05). In addition, we found that GLP-1 mitigated PMN CD11b surface expression in whole rat blood in vitro, an effect that was abolished by GLP-1 receptor blockade (PBS 6.52±0.31 vs. GLP-1 4.78±0.90, TFI, p<0.05). These findings suggest that one mechanism by which GLP-1 decreases reperfusion injury may be the attenuation of PMN-mediated reperfusion injury.
Localized Haptic Texture (2017)

We investigate the relevance of surface haptic rendering techniques for tactile devices. We focus on the two major existing techniques and show that they have complementary benefits. The first one, called textsc{S}urface textsc{H}aptic textsc{O}bject (textsc{SHO}), which is based on finger position, is shown to be more suitable to render sparse textures; while the second one, called textsc{S}urface textsc{H}aptic textsc{T}exture (textsc{SHT}), which is based on finger velocity, is shown to be more suitable for dense textures and fast finger movements. We hence propose a new rendering technique, called textsc{L}ocalized textsc{H}aptic textsc{T}exture (textsc{LHT}), which is based on the concept of textit{taxel} considered as an elementary tactile information that is rendered on the screen. By using a grid of taxels to encode a texture, textsc{LHT} is shown to provide a consistent tactile rendering across different velocities for high density textures, and is found to reduce user textit{error rate} by up to 77.68% compared to textsc{SHO}.
Calmodulin is a major component of extruded trichocysts from Paramecium tetraurelia. (1981)

Extruded trichocysts are composed of a family of proteins with molecular weights between 15,000 and 20,000. We have used heat treatment and affinity chromatography on fluphenazine-Sepharose to purify calmodulinlike proteins from whole cells and from extruded trichocysts. The purified protein from trichocysts is indistinguishable from that of whole cells; it is heat-stable, activates brain phosphodiesterase in a Ca++-dependent fashion, changes mobility on SDS polyacrylamide gels in the presence of Ca++, contains 1 mol of trimethyllysine/17 kdaltons, and has the amino acid composition characteristic of calmodulins. Calmodulin is a major component of purified, extruded trichocysts, of which it represents between 1 and 10% by mass. The other proteins of the trichocyst also resemble calmodulin in several properties. Possible roles for calmodulin in the Ca++-activated extrusion of trichocysts is discussed.
An improved switched injection-locked oscillator for ranging and communication systems (2013)

This paper describes an improved integrated switched injection-locked oscillator (SILO) circuit for use in pulsed angular modulated ultra wideband communication and radar systems, implemented in a 0.25 μm SiGe:C BiCMOS technology. The circuit consists of two active baluns for single-ended to differential and differential to single-ended conversion, a Schmitt-trigger with two pulse generators based on current-starved voltage controlled delay lines and inverter chains and a simple Q-degenerated cross-coupled oscillator for signal generation. It has an externally controllable pulse repetition rate and duration. The previous works of the authors [1] was severely improved in the area of required locking power and pulse duration control. Required injection power has been reduced to -65 dBm. During operation it consumes combined 40mA from 3.3V analog and 2.5V digital supply voltage, while generating a 370mVpp signal. The generated signal has a 10 dB-bandwidth ofs over 2.3 GHz at 6.8 GHz center frequency. Measurement results are shown.
Sequential CD34+ and CD4+ Cell Selection from Leukapheresis Components (1998)

We tested the feasibility of sequential selection of CD34+ and CD4+ cell-enriched fractions from aliquots of five autologous leukapheresis components. CD34+ cells were selected from a median 8.0 x 10(8) mononuclear cells using the CellPro CEPRATE LC cell separation system. All cells in the CD34-depleted fraction (median 4.8 x 10(8), range 0.6-10.0 x 10(8) were then incubated with the appropriate antibodies for CD4+ cell selection and passed through a second LC column. Median target cell purities of the CD34+ cell-enriched fraction and CD4+ cell-enriched fraction were 90.5% and 86.0%, respectively. This study demonstrates that high purity CD34+ and CD4+ cell-enriched fractions can be isolated sequentially from leukapheresis components. In addition, CD8+ lymphocytes, implicated in graft-versus-host disease, were depleted in the course of both positive selection procedures. This approach could decrease the number of donor procedures by providing separate CD34(+)-enriched and CD4(+)-enriched populations for allogeneic peripheral blood progenitor cell transplantation and subsequent donor lymphocyte infusion from the same leukapheresis component.
Интерлейкин-6 – от молекулярных механизмов передачи сигнала к физиологическим функциям и терапевтическим мишеням (2015)

Interleukin-6 (IL-6)--one of the most important pro-inflammatory cytokines that has a broad spectrum of immunoregulatory properties. Molecular mechanisms of signal transduction of IL-6 and its receptor, which were previously established, have recently been supplemented with a concept of trans-signaling. Selective inhibition of this signaling cascade would allow to modulate the pathological effects of IL-6. Methods of reverse genetics have helped to establish the physiological functions of IL-6 in normal state and in various diseases, including neoplasias. Therapeutic inhibitors of IL-6 or its receptor are already used for the treatment of several autoimmune diseases, however, systemic inhibition inevitably also neutralizes the protective functions of this cytokine. It is expected that in the future systemic therapy will be replaced by more specific and effective approaches that take into account the peculiarities of molecular signaling pathways in target cells and differences in the function of IL-6, depending on the cell source.
ChemInform Abstract: Formation and Degradation of an Oxalato‐ and Peroxo‐Bridged Dicobalt BISDIEN Dioxygen Complex. Binuclear Complexes as Hosts for the Activation of Two Coordinated Guests. (1989)

Abstract The rates of metal‐centered degradation of (I) are measured.
The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column (2000)

ABSTRACT The axial skeleton develops from the sclerotome, a mesenchymal cell mass derived from the ventral halves of the somites, segmentally repeated units located on either side of the neural tube. Cells from the medial part of the sclerotome form the axial perichondral tube, which gives rise to vertebral bodies and intervertebral discs; the lateral regions of the sclerotome will form the vertebral arches and ribs. Mesenchymal sclerotome cells condense and differentiate into chondrocytes to form a cartilaginous preskeleton that is later replaced by bone tissue. Uncx4.1 is a paired type homeodomain transcription factor expressed in a dynamic pattern in the somite and sclerotome. Here we show that mice homozygous for a targeted mutation of the Uncx4.1 gene die perinatally and exhibit severe malformations of the axial skeleton. Pedicles, transverse processes and proximal ribs, elements derived from the lateral sclerotome, are lacking along the entire length of the vertebral column. The mesenchymal anlagen for these elements are formed initially, but condensation and chondrogenesis do not occur. Hence, Uncx4.1 is required for the maintenance and differentiation of particular elements of the axial skeleton.
Reversible encephalopathy following 5‐fluorouracil‐based chemotherapy in patients with dihydropyrimidine dehyrogenase deficiency (2009)

Abstract 5‐fluorouracil (5‐FU) is one of the most frequently used chemotherapy agents for the treatment of a number of solid cancers. We report two patients with advanced gastric cancer who developed acute encephalopathy after receiving chemotherapy composed of 5‐FU and oxaliplatin. One patient presented with altered consciousness and the other with generalized tonic clonic seizure. 5‐FU‐induced encephalopathy was suspected by clinical, radiological and electroencephalographic findings, and both patients had reduced expression of dihyropyrimidine dehydrogenase, the rate‐limiting enzyme responsible for the catabolism of 5‐FU. The neurological symptoms improved spontaneously, and did not recur in the following cycle of chemotherapy with the administration of a reduced dose of 5‐FU. We suggest that the early recognition of this adverse event can reverse 5‐FU‐induced neurological symptoms and a dose reduction of the offending drug can prevent the recurrence of 5‐FU induced encephalopathy.
Comparison of isolates of canine parvovirus by restriction enzyme analysis, and vaccine efficacy against field strains (1995)

Canine parvovirus isolates from clinical cases of enteritis were obtained from the United Kingdom, Germany and the USA and differentiated by restriction enzyme analysis into three groups, namely CPV2, CPV2a and CPV2b. The three groups were readily identified by their HphI restriction profile. CPV2 was not prevalent in cases of canine parvovirus disease after 1986. Only two CPV2 strains (original type) were found among 110 strains isolated after 1980. In Europe the frequency of isolation of the CPV2a and CPV2b field strains was similar whereas in the USA the CPV2b strain predominated. Dogs inoculated with a vaccine strain were resistant to infection after challenge with UK isolates of CPV2a and CPV2b.
Short communication: Complete genome sequence of Lactobacillus plantarum J26, a probiotic strain with immunomodulatory activity (2019)

Lactobacillus plantarum J26, a significant probiotic isolated from Chinese traditional fermented dairy products, exerts a positive immunomodulatory effect by regulating the expression of immune-related genes. We investigated expression of the cytokines IL-1α, IL-1β, IL-6, and tumor necrosis factor-α in the intestinal tract of mice stimulated by L. plantarum J26. In vivo, these cytokines were upregulated, peaked on d 5, and then decreased to the control level, indicating that L. plantarum J26 could induce expression of the genes encoding these proinflammatory cytokines. Teichoic acids produced by L. plantarum are recognized as key immunomodulatory molecules involved in the regulation of the host immune response. To better understand the genetic basis of this immunomodulatory mechanism, we sequenced and analyzed the whole genome of L. plantarum J26. The genome of L. plantarum J26 contains a circular chromosome and 4 circular plasmids. Lactobacillus plantarum J26 was predicted to synthesize ribitol-type backbones of wall teichoic acid. Furthermore, orthologous average nucleotide identity (OrthoANI) values showed that the genome was highly similar (>98.00%) to other L. plantarum strains, especially to L. plantarum ST-III and JDM1. The genomic data of L. plantarum J26 provide a genetic basis to further elucidate its mechanism of immunoregulation and will facilitate its application in the functional dairy food industry.
Coordination modes of α-dioximes in uranyl complexes (2014)

α-Dioximes are well-known analytical reagents that comprise two oxime groups. Such ligands have been widely used in the recovery and separation and in analytical determination of d-transition elements. This survey deals with uranyl complexes with α-dioximes, which constitute a new class of uranium(VI) coordination compounds and are distinguished from the other transition-metal glyoximates by unusual coordination modes of the ligand to the central atom.