gebhart/patrepeval huggingface dataset:
Alpha Amino Nitrogen and Fusel Alcohols of Sorghum Worts Fermented into Lager Beer (2001)

The levels of alpha amino nitrogen (AAN) and fusel alcohols during fermentations of lager worts produced from waxy sorghum grits either inoculated with yeast cultured in wort or yeast-malt media were performed. Worts produced from waxy sorghum grits had comparable AAN to commercial wort. The oxygen concentration in the reactor headspace changed from 20% at the beginning of fermentation to less than 1% after 72 hrs fermentation indicating a gradual change from aerobic to anaerobic conditions. The utilization of AAN for production of propanol, isobutanol and amyl-isoamyl alcohols from waxy sorghum grits was comparable to a control wort. Production of propanol, isobutanol and amyl-isoamyl alcohols followed the same trend over 144 hr fermentation. Isobutanol was produced in the lowest concentration. The initiation of propanol production occurred after 24 and 36 hr fermentation for worts inoculated with yeast cultured in wort and yeast-malt media, respectively. The final concentration of ethanol and fusel alcohols were within the expected range found in commercial beers. Worts produced from barley malt and waxy sorghum grits were an adequate substrate for Saccharomyces cerevisiae, and were comparable to a commercial wort. The utilisation of refined waxy sorghum grits as brewing adjuncts for lager beers was demonstrated.
A Hypervisor for Embedded Computing (2008)

Abstract- Mobile applications are a nascent market waiting to be tapped. Next generation mobiles offer a promise of specialized hardware such as multi-touch screens (like the Apple iPhone) or motion sensors (as with the Nintendo Wii) which will enable exciting new applications. In order to make optimal use of these hardware devices, applications must directly interact with the hardware. However, the ability to use native applications carries a certain risk for both device security and reliability. For example, a rogue application could compromise your address book or flood a mobile network. We propose to solve this problem by limiting the access of native applications through confinement in virtual
Ferrocenyl‐Functionalised Terpyridines and Their Transition‐Metal Complexes: Syntheses, Structures and Spectroscopic and Electrochemical Properties (2003)

Abstract Terpyridine ligands of the type Fc′‐X‐tpy′ (Fc′=ferrocenyl or octamethylferrocenyl, X=rigid spacer, tpy′=4′‐substituted 2,2′:6′,2″‐terpyridine) were prepared, crystallographically characterised and used for the synthesis of di‐ and trinuclear bis(terpyridine) complexes of Ru II , Fe II and Zn II . Donor–sensitiser dyads and triads based on Ru II were thoroughly investigated by (spectro)electrochemistry, UV/Vis, transient absorption and luminescence spectroscopy, and an energy level scheme was derived on the basis of the data collected. Intramolecular quenching of the photoexcited Ru II complexes by the redox‐active Fc′ groups can occur reductively and by energy transfer. Both the redox potential of the donor Fc′ and the nature of the spacer X have a decisive influence on excited‐state lifetimes and emission properties of the complexes. Some of the compounds show room‐temperature luminescence, which is unprecedented for ferrocenyl‐functionalised compounds of this kind.
Action des isocyanates sur les benzisothiazol‐2,1 ones‐3 (1H) et sur les thiadiazol‐1,2,4 ones‐5: Un nouveau réarrangement avec extrusion de l'atome de soufre (1980)

Abstract L'action des isocyanates sur les benzisothiaxol‐2,1 ones‐3 (1 H ) et sur les thiadiazol‐1,2,4 ones‐5 a été étudiée. En présence de quantité stoechiométrique de base organique elle conduit, dans les deux cas, à l'incorporation de deux atomes de l'isocyanate dans l'hétérocycle, avec extrusion simultanée de l'atome de soufre.
New Bioactive Metabolites from a Freshwater Isolate of the Fungus Kirschsteiniothelia sp. (1992)

The new cytotoxic naphthoquinone dimer kirschsteinin [5], two new chlorinated diphenyl ethers 8 and 9, three known naphthoquinone derivatives 1, 2, and 7, a monoacetyl derivative of 2, and the (-)-enantiomer of O-methylasparvenone [4], have been isolated from a previously undescribed species of Kirschsteiniothelia. The structures of these compounds were assigned primarily by nmr studies and by spectral comparisons.
Functional and Structural Network Disorganizations in Typical Epilepsy With Centro-Temporal Spikes and Impact on Cognitive Neurodevelopment (2019)

Epilepsy with Centrotemporal Spikes (ECTS) is the most common form of self-limited focal epilepsy. The pathophysiological mechanisms by which ECTS induces neuropsychological impairment in 15-30% of affected children remain unclear. The objective of this study is to review the current state of knowledge concerning the brain structural and functional changes that may be involved in cognitive dysfunctions in ECTS. Structural brain imaging suggests the presence of subtle neurodevelopmental changes over the epileptogenic zone and over distant regions in ECTS. This structural remodeling likely occurs prior to the diagnosis and evolves over time, especially in patients with cognitive impairment, suggesting that the epileptogenic processes might interfere with the dynamics of the brain development and/or the normal maturation processes. Functional brain imaging demonstrates profound disorganization accentuated by interictal epileptic spikes (IES) in the epileptogenic zone and in remote networks in ECTS. Over the epileptogenic zone, the literature demonstrates changes in term of neuronal activity and synchronization, which are effective several hundred milliseconds before the IES. In the same time window, functional changes are also observed in bilateral distant networks, notably in the frontal and temporal lobes. Effective connectivity demonstrates that the epileptogenic zone constitutes the key area at the origin of IES propagation toward distant cortical regions, including frontal areas. Altogether, structural and functional network disorganizations, in terms of: (i) power spectral values, (ii) functional and effective connectivity, are likely to participate in the cognitive impairment commonly reported in children with ECTS. These results suggest a central and causal role of network disorganizations related to IES in the neuropsychological impairment described in ECTS children.
Radiation meets immunotherapy – a perfect match in the era of combination therapy? (2015)

Numerous reports have shown that radiation is capable of tipping the scales from tumor immune evasion to elimination in different tumor types. The next puzzle to be solved is the question of logistics - including types, schedule and dosage of combinatorial RT and CIT strategies.
Purification of an inhibitor of erythroid progenitor cell cycling and antagonist to interleukin 3 from mouse marrow cell supernatants and its identification as cytosolic superoxide dismutase. (1990)

We have isolated a protein from media conditioned by a murine marrow-derived cell line (PB6) and from mouse marrow supernatants that antagonizes interleukin 3-dependent proliferation of cells in culture and reversibly inhibits DNA synthesis of erythroid progenitor cells (BFU-E) in vitro. This protein, p16 (monomer Mr = 16 kD on SDS-PAGE), was purified to homogeneity and amino acid sequencing of a polypeptide fragment yielded a sequence identical to that of murine cytosolic Cu,Zn-containing superoxide dismutase (SOD). The identification of p16 as SOD was confirmed by the detection of SOD enzymatic activity in pure p16 fractions, and when a commercial human erythrocytic SOD preparation was tested it showed the same cell inhibitory activities as p16. These observations show that superoxide dismutase is able to affect the cycling and growth factor responses of hematopoietic cells, activities that have not previously been associated with this enzyme.
A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer (2009)

Although prostate cancer (PrCa) is one of the most common cancers in men in Western countries, little is known about the inherited factors that influence PrCa risk. On the basis of the fact that BRIP1/FANCJ interacts with BRCA1 and functions as a regulator of DNA double-strand break repair pathways, and that germline mutations within the BRIP1/FANCJ gene predispose to breast cancer, we chose this gene as a candidate for mutation screening in familial and young-onset PrCa cases. We identified a truncating mutation, R798X, in the BRIP1/FANCJ gene in 4 out of 2714 UK PrCa cases enriched for familial (2 out of 641; 0.3%) and young-onset cases (2 out of 2073; 0.1%). On screening 2045 controls from the UK population, we found one R798X sequence alteration (0.05%; odds ratio 2.4 (95% CI 0.25-23.4)). In addition, using our data from a genome-wide association study, we analysed 25 SNPs in the genomic region of the BRIP1/FANCJ gene. Two SNPs showed evidence of association with familial and young-onset PrCa (rs6504074; P(trend)=0.04 and rs8076727; P(trend)=0.01). These results suggest that truncating mutations in BRIP1/FANCJ might confer an increased risk of PrCa and common SNPs might also contribute to the alteration of risk, but larger case-control series will be required to confirm or refute this association.
The Cp2TiPh-Mediated Reductive Radical Cyclization of Cyanoketones and Related Reactions. Efficient Trapping of Ketyl Radicals by Cp2TiPh-Coordinated Polar Multiple Bonds (1999)

The reductive radical cyclization of cyanoketones was achieved using Cp(2)TiPh. The Ti(III) reagent was prepared by the sequential addition of i-PrMgCl and PhMgBr to commercial Cp(2)TiCl(2) in this order and used effectively without isolation. The cyclization of the gamma- and delta-cyanoketones was performed in toluene at ambient temperature for several hours to give alpha-hydroxycyclopentanones and hexanones in moderate to good yields, respectively. The titanium reagent independently coordinates to both the carbonyl and cyano termini. As a result of lowering the LUMO of the cyano group upon coordination of the Ti(III) species, the irreversible cyclization successfully proceeds without formation of the unstable iminyl radical intermediate. The ester group can also be activated by the coordination of Cp(2)TiPh, and aromatic ketones with an ester group at the gamma position are cyclized to give the corresponding alpha-hydroxyketones.
Big Prime Field FFT on Multi-core Processors (2019)

We report on a multi-threaded implementation of Fast Fourier Transforms over generalized Fermat prime fields. This work extends a previous study realized on graphics processing units to multi-core processors. In this new context, we overcome the less fine control of hardware resources by successively using FFT in support of the multiplication in those fields. We obtain favorable speedup factors (up to 6.9x on a 6-core, 12 threads node, and 4.3x on a 4-core, 8 threads node) of our parallel implementation compared to the serial implementation for the overall application thanks to the low memory footprint and the sharp control of arithmetic instructions of our implementation of generalized Fermat prime fields.
[Efficacy of the vaginal administration of natural progesterone in patients with recurrent spontaneous hormone caused abortion]. (2000)

These results lead us to conclude that natural progesterone treatment in patients with a confirmed hormone deficiency during the luteal phase does not reduce the risk of abortion in the overall population of pregnant women, but improves the prognosis compared to the group of women suffering from multiple abortions, thereby reducing the risk to that in the general population.
Detecting apoptosis using dynamic light scattering with optical coherence tomography (2011)

A dynamic light scattering technique is implemented using optical coherence tomography (OCT) to measure the change in intracellular motion as cells undergo apoptosis. Acute myeloid leukemia cells were treated with cisplatin and imaged at a frame rate of 166 Hz using a 1300 nm swept-source OCT system at various times over a period of 48 h. Time correlation analysis of the speckle intensities indicated a significant increase in intracellular motion 24 h after treatment. This rise in intracellular motion correlated with histological findings of irregularly shaped and fragmented cells indicative of cell membrane blebbing and fragmentation.
Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study (2007)

Hemorrhagic stroke was more frequent in those treated with atorvastatin, in those with a hemorrhagic stroke as an entry event, in men, and increased with age. Those with Stage 2 hypertension at the last visit prior to the hemorrhagic stroke were also at increased risk. Treatment did not disproportionately affect the hemorrhagic stroke risk associated with these other factors. There were no relationships between hemorrhage risk and baseline low-density lipoprotein (LDL) cholesterol level or recent LDL cholesterol level in treated patients.
The limiting concentration dependence of the heat of transport in electrolyte solutions (1986)

The limiting concentration dependence of the heat of transport of electrolyte solutions has been investigated. The ionic contribution to the Onsager phenomenological coefficients for heat-matter coupling Lqi have been calculated by the time-correlation function method using the Fokker–Planck operator as the time-evolution operator. It is shown that the limiting slope due to the direct ion–ion electrostatic effect obtained in the present work agrees with the result in the literature. It is also shown that the contribution to the limiting slope due to ion–solvent interaction may be written in terms of the differences in the Stokes law radii of the ions as well as the reduced ionic heats of transport at infinite dilution. Although our result resembles Agar’s result based on a hydrodynamic theory, we point out that there exist substantial differences in the implications of the two results. Finally, an error in the theory of Kahana and Lin [J. Chem. Phys. 75, 5043 (1981)] has been uncovered and corrected.
PROTEIN ANABOLISM AND FATTY LIVER OF THE ALCOHOLIC (1967)

From the Division of Hepatic Metabolism and Nutrition, Department of Medicine, New Jersey College of Medicine, and the Veterans Administration Hospital, East Orange, New Jersey 1Postdoctoral trainee, National Institutes of Health, Graduate Training Grant TI AM 5236
Monoclonal Antibodies Directed Against Human Lymphoid, Monocytic, and Granulocytic Cells: Reactivities with Other Tissues (1983)

Monoclonal antibodies (MAbs) reactive with lymphoid cells are not necessarily specific for lymphoid tissues. Forty MAbs with varying degrees of specificity in lymphoid tissue were tested against a wide battery of nonlymphoid human tissues. Cross-reactivity was identified in 18 of 41 antibodies tested. Based on their reactivities, the MAbs were classified in three groups: (1) antibodies with wide reactivities in normal nonlymphoid tissues, i.e., anti-Leu 4, anti-Leu M1, OKT9, anti-HLA-Dr, anti-Leu M2, Mo-2 (Coulter), anti-Leu 7, BA-1, BA-2, BA-3, J5, and A1G3; (2) antibodies with limited reactivities in nonlymphoid tissues (one or two tissues), i.e., OKT6, anti-Leu 10, Mo-1 (BRL), Mo-2 (BRL); and (3) antibodies without cross reactivities in nonlymphoid tissues, i.e., anti-Leu 1, anti-Leu 2a, anti-Leu 3a, OKT3, OKT10, 3A1, anti-Leu 8, TA-1, Lyt 3, B1, B2, OKMo-1, anti-Leu M3, T200. The reactions can be attributed to the presence of a similar, if not identical, epitope in related or different molecules.
Superabsorbent hydrogel composites with a focus on hydrogels containing nanofibers or nanowhiskers of cellulose and chitin (2013)

ABSTRACT The development of superabsorbent hydrogels (SHs) is a very important issue in both academic and industrial fields because of their applications in several technologies. The impressive number of publications dealing with SH confirms this statement: a quick search in the ISI (Web of Science) database under the words superabsorbent hydrogels revealed more than 600 articles published, with about 80% of those published in last decade. Current studies on the development of SHs have focused on the formulation of highly functional materials with enhanced properties for suitable applications in different fields. In light of this, the incorporation of microsized or nanosized materials in SH formulations has been explored as a very attractive strategy for tailoring desired properties. In this review, we discuss relevant aspects of the current knowledge of SHs and nanocomposite polymer hydrogels, mainly those based on chitin and cellulose nanocrystals (fibers and/or whiskers), bringing to light some structure–property relationships and future trends. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 39725.
Fas and Fas Ligand Expressed on Cells of the Immune System, not on the Target Tissue, Control Induction of Experimental Autoimmune Uveitis (2000)

The Fas-Fas ligand (FasL) interaction is important for maintaining lymphocyte homeostasis by signaling for activation-induced cell death. Mice homozygous for the lpr or gld mutations do not express functional Fas or FasL, respectively, and spontaneously develop progressive autoimmune symptoms. Recent studies implicated expression of FasL on immunologically privileged tissues in protection from immune-mediated damage. Conversely, tissue expression of Fas may facilitate damage. We evaluated the susceptibility of lpr and gld mice to induction of experimental autoimmune uveitis (EAU), a T cell-mediated autoimmune disease induced with retinal Ags, which targets the neural retina. gld as well as lpr mice immunized with a retinal Ag developed disease of lower incidence and severity than wild-type controls. Delayed hypersensitivity responses were not significantly different among immunized gld, lpr, or wild-type mice, although in vitro Ag-specific lymphocyte responses of the mutant mice were lower. To evaluate whether the diminished ability of gld and lpr mice to develop EAU was due to a defect at the level of the tissue or the immune system, radiation bone marrow chimeras constructed between wild-type and mutant mice were immunized to induce EAU. Mutant recipients of wild-type bone marrow, but not wild-type recipients of mutant bone marrow, developed normal disease scores. These results indicate that normal expression of Fas and of FasL on cells of the immune system is important for EAU expression. Unexpectedly, neither lack of Fas nor lack of FasL on the ocular tissues affected expression of EAU.
β 2-microglobulin modified with advanced glycation end products modulates proliferation of human fibroblasts via a pathway mediated by rAGE (1999)

AIM:To test the hypothesis that fibroblast may be a target for the biological action of β 2-microglobulin modified with advanced glycation end products(AGE-β 2M).METHODS:Radioligand-binding study;-TdR and direct density quantification.RESULTS: 125 I-AGE-β 2M bound to a human skin fibroblast cell line(HSF) in a specific,dose-dependent manner,a process inhibited in the presence of anti-RAGE IgG.HSFs exposed to AGE-β 2M showed upregulation of proliferation which could be inhibited by anti-RAGE IgG,but not by anti-epidermal growth factor neutralizing antibody.CONCLUSION:AGE-β 2M may play a role in the pathogenesis of dialysis-related amyloidosis via a pathway involving a fibroblast receptor for AGE.
Stereospecific Formation of (24E)-3α, 7α, 12α-Trihydroxy-5β-Cholest-24-En-26-Oic Acid and (24R,25S)-3α, 7α, 12α, 24-Tetrahydroxy-5β-Cholestan-26-Oic Acid from Either (25R)-or (25S)-3α, 7α,12α-Trihydroxy-5β-Cholestan-26-Oic Acid by Rat Liver Homogenate12 (1984)

Studies of the stereochemistry of the intermediates, 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid and 3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid, in the biosynthetic sequence between 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid and cholic acid have been undertaken. (25R)- or (25S)-3 alpha,7 alpha, 12 alpha-Trihydroxy-5 beta-cholestan-26-oic acid was incubated with rat liver homogenates. The reaction products were converted to p-bromophenacyl ester derivatives and the esters were analyzed by high-performance liquid chromatography. By comparison with authentic samples of two (24E)- and (24Z)-isomers of the alpha, beta-unsaturated acid and of four isomers at C-24 and C-25 of the beta-hydroxy acid, (24E)-3 alpha,7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-oic acid and (24R,25S)-3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid were found to be formed from either (25R)- or (25S)-3 alpha,7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-oic acid. No formation of the (24Z)-isomer of the trihydroxycholestenoic acid or the other three isomers of the tetrahydroxycholestanoic acid was detected. The findings are discussed in relation to the assumed pathway for side chain cleavage in cholic acid biosynthesis.
A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. (1989)

Nonradioactive sequence-specific oligonucleotide probes specific for the HLA-DP beta locus have been used in a simple dot-blot format to type samples amplified by the polymerase chain reaction from 44 patients with pauciarticular juvenile rheumatoid arthritis, 32 patients with adult rheumatoid arthritis, and 50 random controls. The sequences of four new DP beta alleles derived from these patients and controls are reported, bringing the total number of alleles identified thus far to 19. The DPB2.1 allele is significantly increased in juvenile rheumatoid arthritis patients over controls; this allele is not increased in patients with adult rheumatoid arthritis. The association of juvenile rheumatoid arthritis with the DPB2.1 allele is independent of linkage with previously defined HLA-D region markers of disease. Analysis of the DPB2.1 sequence shows that it differs from the nonsusceptible DPB4.2 allele by only 1 amino acid at position 69 in the beta 1 domain.
Table S3 from Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy (2023)

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Recent advances in 3D bioprinted tumor models for personalized medicine (2023)

Cancerous tumors are among the most fatal diseases worldwide, claiming nearly 10 million lives in 2020. Due to their complex and dynamic nature, modeling tumors accurately is a challenging task. Current models suffer from inadequate translation between in vitro and in vivo results, primarily due to the isotropic nature of tumors and their microenvironment's relationship. To address these limitations, hydrogel-based 3D bioprinting is emerging as a promising approach to mimic cancer development and behavior. It provides precise control over individual elements' size and distribution within the cancer microenvironment and enables the use of patient-derived tumor cells, rather than commercial lines. Consequently, hydrogel bioprinting is expected to become a state-of-the-art technique for cancer research. This manuscript presents an overview of cancer statistics, current modeling methods, and their limitations. Additionally, we highlight the significance of bioprinting, its applications in cancer modeling, and the importance of hydrogel selection. We further explore the current state of creating models for the five deadliest cancers using 3D bioprinting. Finally, we discuss current trends and future perspectives on the clinical use of cancer modeling using hydrogel bioprinting.