gebhart/patrepeval huggingface dataset:
The Forces Exerted on the Duodenum and Sphincter of Oddi During ERCP, and Sphincterotomy (1996)

Little is known about the forces transmitted to the tip of the endoscope or about forces exerted by manipulating accessories in the biopsy channel of a flexible endoscope. Every endoscopist is concerned about the possibility of perforation of viscera while manoeuvring the endoscope. Perforation is an occasional complication of endoscopic retrograde cholangiopancreatography (ERCP) and sphincterotomy [1-11]. Pushing the endoscope, angulating the tip of the endoscope, rotatory movements (torque) of the endoscope, pushing accessories through the channel of duodenoscope, flexing the tip of the cannula or sphincterotome by movements of the bridge, and bowing the sphincterotome are some commonly performed manoeuvres to cannulate the sphincter of Oddi and perform sphincterotomy. The aim of this study was to measure the forces exerted on the duodenum and sphincter of Oddi during endoscopic sphincterotomy and to evaluate the force required to actually perforate the stomach and duodenum in bench experiments.
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma (2014)

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all samples. The mean nonsilent somatic mutation rate was 1.2 mutations per megabase, and there was a median of 230 somatic rearrangements per tumor. Complex chains of rearrangements and localized hypermutation were detected in almost all cases. Given the intertumor heterogeneity, the extent of genomic instability, and the difficulty in acquiring a large sample size in a rare tumor, we used several methods to identify genomic events contributing to osteosarcoma survival. Pathway analysis, a heuristic analytic algorithm, a comparative oncology approach, and an shRNA screen converged on the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway as a central vulnerability for therapeutic exploitation in osteosarcoma. Osteosarcoma cell lines are responsive to pharmacologic and genetic inhibition of the PI3K/mTOR pathway both in vitro and in vivo.
Optical and scintillation properties of CeCl3 and Ce doped LaBr3 single crystals grown by modified micro-pulling-down method (2010)

We developed a modified micro-pulling-down (μ-PD) method for crystal growth of halide materials with hygroscopic nature. By the modified μ-PD method, CeCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and Ce doped LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> [Ce: LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ] single crystals were grown and the crystals indicated high transparency. In the photoluminescence measurements, emissions of Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> ion 5d-4f transition were observed in the both crystals of CeCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and Ce: LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . Emission peak originated from 5d-4f transition of Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> ion were observed around 430 nm by radiation from X-ray. In the decay curve of Ce:LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> single crystal with radiation of γ-ray from <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs source, decay time was about 36 ns.
New and Old Anti-CD20 Monoclonal Antibodies for Nephrotic Syndrome. Where We Are? (2022)

Nephrotic proteinuria is the hallmark of several glomerulonephritis determined by different pathogenetic mechanisms, including autoimmune, degenerative and inflammatory. Some conditions such as Minimal Change Nephropathy (MCN) and Focal Segmental Glomerulosclerosis (FSGS) are of uncertain pathogenesis. Chimeric anti-CD20 monoclonal antibodies have been used with success in a part of proteinuric conditions while some are resistant. New human and humanized monoclonal anti-CD 20 antibodies offer some advantages based on stronger effects on CD20 cell subtypes and have been already administered in hematology and oncology areas as substitutes of chimeric molecules. Here, we revised the literature on the use of human and humanized anti-CD 20 monoclonal antibodies in different proteinuric conditions, resulting effective in those conditions resistant to rituximab. Literature on the use of human anti-CD 20 monoclonal antibodies in different proteinuric diseases is mainly limited to ofatumumab, with several protocols and doses. Studies already performed with ofatumumab given in standard doses of 1,500 mg 1.73m<sup>2</sup> suggest no superiority compared to rituximab in children and young adults with steroid dependent nephrotic syndrome. Ofatumumab given in very high doses (300 mg/1.73m<sup>2</sup> followed by five infusion 2,000 mg/1.73 m<sup>2</sup>) seems more effective in patients who are not responsive to common therapies. The question of dose remains unresolved and the literature is not concordant on positive effects of high dose ofatumumab in patients with FSGS prior and after renal transplantation. Obinutuzumab may offer some advantages. In the unique study performed in patients with multidrug dependent nephrotic syndrome reporting positive effects, obinutuzumab was associated with the anti-CD38 monoclonal antibody daratumumab proposing the unexplored frontier of combined therapies. Obinutuzumab represent an evolution also in the treatment of autoimmune glomerulonephritis, such as membranous nephrotahy and lupus nephritis. Results of randomized trials, now in progress, are awaited to add new possibilities in those cases that are resistant to other drugs. The aim of the present review is to open a discussion among nephrologists, with the hope to achieve shared approaches in terms of type of antibodies and doses in the different proteinuric renal conditions.
Role of Fly Ash in the Removal of Organic Pollutants from Wastewater (2009)

Fly ash, a relatively abundant and inexpensive material, is currently being investigated as an adsorbent for the removal of various organic pollutants from wastewater. The wastewater contains various types of phenolic compounds, such as chloro, nitro, amino, and other substituted compounds. Various types of pesticides, such as lindane, malathion, carbofuran, etc., and dyes, such as, methylene blue, crystal violet, malachite green, etc., are also present in the wastewater. These contaminants pollute the water stream. These organic pollutants, such as phenolic compounds, pesticides, and dyes, etc., can be removed very effectively using fly ash as adsorbent. This article presents a detailed review on the role of fly ash in the removal of organic pollutants from wastewater. Adsorption of various pollutants using fly ash has been reviewed. The adsorption mechanism and other influencing factors, favorable conditions, and competitive ions, etc., on the adsorption process have also been discussed in this paper. It is evident from the review that fly ash has demonstrated good removal capabilities for various organic compounds.
Mean force on a small sphere in a sound field in a viscous fluid (2000)

A mean force exerted on a small rigid sphere by a sound wave in a viscous fluid is calculated. The force is expressed as a sum of drag force coming from the external steady flow existing in the absence of the sphere and contributions that are cross products of velocity and velocity derivatives of the incident field. Because of the drag force and an acoustic streaming generated near the sphere, the mean force does not coincide with the acoustic radiation pressure, i.e., the mean momentum flux carried by the sound field through any surface enclosing the sphere. If the sphere radius R is considerably smaller than the viscous wave penetration depth delta, the drag force can give the leading-order contribution (in powers of delta/R) to the mean force and the latter can then be directed against the radiation pressure. In another limit, delta< or =R, the drag force and acoustic streaming play a minor role, and the mean force reduces to the radiation pressure, which can be expressed through source strengths of the scattered sound field. The effect of viscosity can then be significant only if the incident wave is locally plane traveling.
Statistical Analysis of Circular Data (1993)

Data measured as angles or two-dimensional orientations are found almost everywhere in science. They commonly arise in biology, geography, geophysics, medicine, meteorology and oceanography, and many other areas. Examples of such data include departure directions of birds from release points, fracture plane orientations, the directional movement of animals after stimulation, wind and ocean current directions, and biorhythms. Statistical methods for handling such data have developed rapidly in the last twenty years, particularly data display, correlation, regression and analysis of tempered or spatially structured data. Further, some of the exciting modern developments in general statistical methodology, particularly nonparametric smoothing methods and bootstrap-based methods, have contributed significantly to relatively intractable data analysis problems. This book provides a unified and up-to-date account of techniques for handling circular data.
Particle Adsorption on Polymer Gel Surface Driven by van der Waals Attraction (2022)

Abstract Adsorption of particles on soft hydrogels, which plays an important role in various scientific and industrial fields, has often been studied using interactions such as hydrogen bonding. Here, we demonstrate that submicron-sized colloidal particles can be adsorbed onto gels, solely by van der Waals (vdW) attraction, without any special interaction. We investigated the adsorption of silica, polystyrene, and titania particles on polyacrylamide (PAAm) and polydimethylacrylamide (PDMA) hydrogels. The vdW force was tuned by the refractive index of media. Previously, we studied the particle adsorption on gels (N. Sato et al., Sci. Rep. 7(1), 2017) and concluded that the vdW force is a strong driving force. However, the influence of the medium viscosity on the adsorption rate and the contribution of interactions other than the vdW force needed to be clarified. The PDMA linear polymer adsorbed strongly on the silica particles, but the PAAm polymer did not. On the other hand, both PDMA and PAAm hydrogels strongly adsorbed silica and all other particles in water. The amount of adsorption varied with the magnitude of Hamaker constant. These results indicate that the vdW force is a sufficiently strong driving force for the particle adsorption to polymer hydrogel surfaces in water.
Late presentation of HIV infection: a consensus definition (2010)

The European Late Presenter Consensus working group believe it would be beneficial if all national health agencies, institutions, and researchers were able to implement this definition (either on its own or alongside their own preferred definition) when reporting surveillance or research data relating to late presentation of HIV infection.
Optimizing databases by learning hidden parameters of solid state drives (2019)

Solid State Drives (SSDs) are complex devices with varying internal implementations, resulting in subtle differences in behavior between devices. In this paper, we demonstrate how a database engine can be optimized for a particular device by learning its hidden parameters. This can not only improve an application's performance, but also potentially increase the lifetime of the SSD. Our approach for optimizing a database for a given SSD consists of three steps: learning the hidden parameters of the device, proposing rules to analyze the I/O behavior of the database, and optimizing the database by eliminating violations of these rules. We obtain two different characteristics of an SSD, namely the request size profile and the location profile , from which we learn multiple internal parameters. Based on these parameters, we propose rules to analyze the I/O behavior of a database engine. Using these rules, we uncover sub-optimal I/O patterns in SQLite3 and MariaDB when running on our experimental SSDs. Finally, we present three techniques to optimize these database engines: (1) use-hot-locations on SSD-S, which improves the SELECT operation throughput of SQLite3 and MariaDB by 29% and 27% respectively; it also improves the performance of YCSB on MariaDB by 1%-22% depending on the workload mix, (2) write-aligned-stripes on SSD-T, reduces the wear-out caused by SQLite3 write-ahead log (WAL) file by 3.1%, and (3) contain-write-in-flash-page on SSD-T, which reduces the wear-out caused by the MariaDB binary log file by 6.7%.
Motion-blurred Video Interpolation and Extrapolation (2021)

Abrupt motion of camera or objects in a scene result in a blurry video, and therefore recovering high quality video requires two types of enhancements: visual enhancement and temporal upsampling. A broad range of research attempted to recover clean frames from blurred image sequences or temporally upsample frames by interpolation, yet there are very limited studies handling both problems jointly. In this work, we present a novel framework for deblurring, interpolating and extrapolating sharp frames from a motion-blurred video in an end-to-end manner. We design our framework by first learning the pixel-level motion that caused the blur from the given inputs via optical flow estimation and then predict multiple clean frames by warping the decoded features with the estimated flows. To ensure temporal coherence across predicted frames and address potential temporal ambiguity, we propose a simple, yet effective flow-based rule. The effectiveness and favorability of our approach are highlighted through extensive qualitative and quantitative evaluations on motion-blurred datasets from high speed videos.
Structural analysis of staphylococcal enterotoxins B and C1 using circular dichroism and fluorescence spectroscopy (1988)

Secondary and tertiary structural parameters of two functionally and serologically related proteins, staphylococcal enterotoxins B and C1, have been determined by using circular dichroism and fluorescence spectroscopy. The secondary structures derived from the respective far-UV circular dichroic spectra were 9.5% alpha-helix, 55.0% beta-pleated sheets, 16.5% beta-turns, and 19.0% random coils for enterotoxin B and 15.0% alpha-helix, 38.0% beta-pleated sheets, 25.5% beta-turns, and 21.5% random coils for staphylococcal enterotoxin C1. The values matched well with the secondary structures derived from the amino acid sequences (Chou and Fasman method). Seven antigenic sites have been predicted for both staphylococcal enterotoxins B and C1 by using the hydrophilicity and the secondary structure information. Three of these antigenic sites appear similar. Fluorescence quantum yield of the single tryptophan residue (Trp-197) of both the enterotoxins showed the tryptophan residue in staphylococcal enterotoxin B to be approximately 46% more fluorescent than in staphylococcal enterotoxin C1. Tryptophan fluorescence quenching by the surface quencher I- and the neutral quencher acrylamide revealed that the single tryptophan residue in each of the enterotoxins is buried in the protein matrix and is not accessible to the surface quencher I-. The tryptophan residue in staphylococcal enterotoxin C1 is 14% less accessible to acrylamide than in staphylococcal enterotoxin B. The data, in general, reflect several similarities and significant differences between the two related enterotoxins.
Errata.-Application of Thermal Barriers to High-Temperature Engine Components (1973)

T present trend to more severe operating conditions in turbine engines will require fairly sophisticated cooling schemes. The thermal barrier, a low conductivity coating, is a means of reducing the cooling requirements. The chief benefit of a thermal barrier is a saving in cooling air and thus less loss in engine performance. Compared with other cooling methods, thermal barriers are most beneficial in engines with large heat-transfer coefficients—i.e., high-pressure ratios. Results of a test program to match or exceed engine burner liner or vane leading edge requirements with selected ceramic thermal barriers are presented. The materials tested were alumina (high thermal shock resistance), zirconia (low thermal conductivity), and zircon foam (very low conductivity).
Cost analysis of IP mobility management protocols for consumer mobile devices (2010)

The rapid progress being made in mobile device technologies that enable consumers can enjoy Internet based multimedia/business services in travel will rely on IP mobility management protocols for enabling mobile services. The performance of mobility management protocols will largely effect on consumers¿ experiences. In this paper, an analytical cost model is developed for evaluating the performance of the existing IP mobility management protocols including the recently developed Proxy Mobile IPv6 (PMIPv6); they are analyzed and compared in terms of signaling cost, packet delivery cost, tunneling cost, and total cost. The conducted results identify each mobility management protocol¿s strengths and weaknesses that could be used to facilitate decision-making for consumer network design. In addition, suggestions for developing further PMIPv6 improvements are provided.
Ethnic and socio-cultural specificities in Tunisia have no impact on the prevalence of anti-Saccharomyces cerevisiaeantibodies in Crohn's disease patients, their relatives or associated clinical factors (2007)

This study confirms the antigenic heterogeneity of S. cerevisiae strains in their ability to detect ASCA. It suggests that ASCAs are markers of immunoregulatory disturbance in CD, independently of ethnic/cultural differences between Europe, the USA and North Africa.
Balloon angioplasty and stenting of multiple intralobar pulmonary arterial stenoses in adult patients (2003)

Balloon angioplasty and stent placement for pulmonary arterial stenoses in children are well-established therapies. In contrast, management of isolated peripheral pulmonary arterial stenoses in adults remains relatively unexplored. Four women (ages 18-63 years) with multiple discrete intralobar pulmonary arterial stenoses were treated with balloon angioplasty. Initially, 4-5 stenoses were dilated in each patient. The mean minimum diameter of the stenoses increased from 1.3 to 3.1 mm (P < 0.001), and the mean ratio of right ventricular to aortic systolic pressure decreased from 0.92 to 0.62 (P < 0.05). Each patient had marked symptomatic improvement. However, three patients developed recurrence of symptoms 4-24 months after angioplasty, and two had angiographic evidence of restenosis at previously dilated sites. These restenoses were treated with repeat angioplasty or stent implantation (three stents in each patient). One of these two patients developed near-occlusive restenosis of the stents and had successful bilateral lung transplantation. The other patient had a third catheterization with successful implantation of three additional stents. The third patient with recurrent symptoms died 2 years later, without further intervention. Transcutaneous catheter therapy for multiple intralobar pulmonary arterial stenoses in adults is highly successful acutely, but restenosis is common within several months. For some patients, balloon angioplasty and stent implantation may provide definitive management, while for others these procedures may serve as a bridge to lung transplantation.
Evolution of immunogenetic components used to form ultralong VH CDR3 antibodies in Bovidae (2021)

Abstract Cattle has a restricted repository of immunoglobulin heavy chain gene segments with only one family of V, 4 J and 16 D segments functional. Among these segments are a V and D that, together, encode a heavy chain with an ultralong CDR3 region which manifests as a “stalk” supporting a “knob” domain of which only the knob has antigen binding capability. This antibody structure has boundless therapeutic potential, including for treatment of HIV and other antigens with veiled epitopes. Upon the discovery of this ultralong antibody in Bos taurus, speculation of its origin began. The components that should facilitate ultralong CDR3H antibodies appear in more species than just Bos taurus; they expand throughout the bovine subfamily as evidence by the presence of a V motif “TTVHQ” crested by an 8 base-pair (bp) duplication, and a comparatively long D segment. Several closely-related species encode the ultralong V segments gene in their germline IgH locus. Phylogenetically bookending the cluster that is genomically equipped for the ultralong cattlebody are the species Bos taurus and Bison bison with Bos mutus, indicus, and grunniens in between. The added length of the D segment is less consistent throughout the group as none of the species encode as long of segment as Bos taurus at 50 amino acids. Two species studied, Bos mutus and Bos grunniens, have 15 and 22 amino acids, respectively, encoded by their longest D segment, and Bison bison has 23. Though we do know the germline encodes the ultralong antibody, it is imperative to know if the gene rearrangement is actually expressed and employed in the mature repertoire.
Identification of Residues Involved in Substrate Recognition by a Vesicular Monoamine Transporter (1995)

To identify the residues involved in substrate recognition by recently cloned vesicular monoamine transporters (VMAT1 and VMAT2), we have mutagenized the conserved residues in a cytoplasmic loop between transmembrane domains two and three of VMAT2. Although studies of related bacterial antibiotic resistance proteins indicate an important functional role for this region, we found no effect of these mutations on VMAT2 activity. However, replacement of aspartate 33 in the first predicted transmembrane domain with an asparagine (D33N) eliminates transport. D33N shows normal levels of expression and normal binding at equilibrium to the potent inhibitor reserpine. However, in contrast to wild-type VMAT2, serotonin inhibits reserpine binding to D33N very poorly, indicating a specific defect in substrate recognition. Replacement of three serine residues in transmembrane domain three with alanine (Stmd3A) shows a similarly selective but even more profound defect in substrate recognition. The results suggest that by analogy to receptors and plasma membrane transporters for monoamines, the cationic amino group of the ligand interacts with an asparte in the first transmembrane domain of VMAT2 and hydroxyl groups on the catechol or indole ring interact with a group of serines in the third transmembrane domain. Importantly, D33N and Stmd3A retain coupling to the proton electrochemical gradient as measured by the delta microH(+)-induced acceleration of reserpine binding. This indicates that substrate recognition can be separated from coupling to the driving force.