gebhart/patrepeval huggingface dataset:
Data from Aerosol Administration of Phospho-Sulindac Inhibits Lung Tumorigenesis (2023)

&lt;div&gt;Abstract&lt;p&gt;Phospho-sulindac is a sulindac derivative with promising anticancer activity in lung cancer, but its limited metabolic stability presents a major challenge for systemic therapy. We reasoned that inhalation delivery of phospho-sulindac might overcome first-pass metabolism and produce high levels of intact drug in lung tumors. Here, we developed a system for aerosolization of phospho-sulindac and evaluated the antitumor efficacy of inhaled phospho-sulindac in an orthotopic model of human non–small cell lung cancer (A549 cells). We found that administration by inhalation delivered high levels of phospho-sulindac to the lungs and minimized its hydrolysis to less active metabolites. Consequently, inhaled phospho-sulindac (6.5 mg/kg) was highly effective in inhibiting lung tumorigenesis (75%; &lt;i&gt;P&lt;/i&gt; &lt; 0.01) and significantly improved the survival of mice bearing orthotopic A549 xenografts. Mechanistically, phospho-sulindac suppressed lung tumorigenesis by (i) inhibiting EGF receptor (EGFR) activation, leading to profound inhibition of Raf/MEK/ERK and PI3K/AKT/mTOR survival cascades; (ii) inducing oxidative stress, which provokes the collapse of mitochondrial membrane potential and mitochondria-dependent cell death; and (iii) inducing autophagic cell death. Our data establish that inhalation delivery of phospho-sulindac is an efficacious approach to the control of lung cancer, which merits further evaluation. &lt;i&gt;Mol Cancer Ther; 12(8); 1417–28. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
E-Graphs: Bootstrapping Planning with Experience Graphs (2021)

In this paper, we develop an online motion planning approach which learns from its planning episodes (experiences) a graph, an Experience Graph. On the theoretical side, we show that planning with Experience graphs is complete and provides bounds on suboptimality with respect to the graph that represents the original planning problem. Experimentally, we show in simulations and on a physical robot that our approach is particularly suitable for higher-dimensional motion planning tasks such as planning for two armed mobile manipulation.
Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma (2013)

Elevated expression of MyD88 may promote tumor growth and metastasis via both TLR/IL-1R-dependent and -independent signaling and may serve as a biomarker for prognosis of patients with HCC.
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids. (1990)

The alpha-aminoboronic acid analog of proline has been synthesized and incorporated into a number of peptides as the COOH-terminal residue. These peptide prolyl boronic acids are potent inhibitors of both the type 1 and type 2 IgA proteinases from Neisseria gonorrhoeae and Hemophilus influenzae, but not of the functionally similar IgA proteinase from Streptococcus sanguis. The best inhibitors synthesized thus far have Ki values in the nanomolar range (4.0 to 60 nM). These results indicate that the N. gonorrhoeae and the H. influenzae enzymes belong to the serine protease family of proteolytic enzymes while that from S. sanguis does not. As a group, the IgA proteinases have been noted for their remarkable specificity; thus, the peptide prolyl boronic acids reported here are the first small synthetic molecules to exhibit a relatively high affinity for the active site of an IgA proteinase and are therefore the first to yield some insight into the active site structure and specificity requirements of these enzymes.
The Strength of Piezoelectricity in Liquid Crystals (1971)

Abstract A simple method combining macroscopic and microscopic features is proposed to calculate approximate values for Meyer's piezoelectric coefficients. The numerical result suggests that the piezoelectricity of liquid crystals is weak and its effect on alignment fluctuations mostly negligible.
Wear Resistance and Hardness Assessment of Five US Hardwoods for Bridge Decking and Truck Flooring* (2022)

Abstract The wear resistance and Janka hardness of five United States hardwood species were evaluated for potential use in bridge decking and truck flooring. The species tested include ash (Fraxinus sp.), hickory (Carya sp.), red oak (Quercus sp.), sweetgum ( Liquidambar styraciflua ), and white oak (Quercus sp.). The specimens were prepared with the sizes of 1 by 2 by 4 inches (2.54 by 5.08 by 10.16cm) for abrasion test and 1 by 2 by 6 inches (2.54 by 5.08 by 15.24 cm) for Janka hardness testing. The specimens were cut from 30 individual parent boards of random width with clear sections for each species. The abrasion and Janka hardness tests were performed according to the American Society of Testing and Materials standards. All wear and hardness data were statistically analyzed by 1-way analysis of variance. The results of this study demonstrated that sweetgum with the lowest density had the greatest amount of thicknesses loss and thus lowest wear resistance. White oak was found to have the least thicknesses loss, thus highest wear resistance among the hardwood species tested. Hickory, with the highest density, had the highest hardness among the hardwood species tested, but it had relatively lower wear resistance comparing to ash, red oak, and white oak.
The Interaction of Temperature and Bending Load on Structural Performance of Chinese Larch Wood (2012)

Wood is being used extensively in timber construction in China. In fire-resistant design for timber construction, the main goal is to ensure that enough structural integrity is maintained during a fire to prevent structure collapse. It is important to understand its structural performance when exposed to elevated temperatures and loaded by stress levels. To study the interaction effect of Chinese larch wood, a total of 72 small clear wood samples were observed under constant stress levels when the wood temperature was elevated. The results indicated that Chinese larch wood was more susceptible to the coupling effect of temperature and stress. The interaction promoted a temporary stable flexural structure to collapse during a short exposure time.
Supplementary Figure 1 from Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti–PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells (2023)

&lt;p&gt;Dose response curves for avelumab-mediated ADCC assays of 3 human cancer cell lines using purified NK cells from the same healthy donor as effectors at an effector:target ratio of 25:1.&lt;/p&gt;
Anaplasma phagocytophilum (2017)

Equine granulocytic anaplasmosis (EGA, formerly equine granulocytic ehrlichiosis) is caused by the tick-transmitted bacterium, Anaplasma phagocytophilum, which infects horse, human, and canine leukocytes, causing an acute febrile disease. Most infected horses manifest no clinical signs and recover without incident, particularly if they are young when first exposed, while more severe disease is typical in older horses. this chapter summarizes epidemiological features; these features reflect that the disease is predominantly tick-transmitted and occurs where there is overlap with Ixodes scapularis, deer tick, or black legged tick or I. pacificus, the western black-legged tick. Various serologic diagnostic tests have been developed to detect antibodies to A. phagocytophilum and are offered at commercial laboratories. The most appropriate uses of serology are to retrospectively confirm a diagnosis if polymerase chain reaction (PCR) testing was negative or not available, or to test for the occurrence of A. phagocytophilum infection in a new geographical area or herd of horses.
3D MHD Simulations of Disk Accretion onto Magnetized Stars: Numerical Approach and Sample Simulations (2009)

We present results of global 3D MHD simulations of disk accretion to a rotating star with dipole and more complex magnetic fields using a Godunov-type code based on the "cubed sphere" grid developed earlier in our group. We describe the code and the grid and show examples of simulation results.
The Antifungal Action Mode of N-Phenacyldibromobenzimidazoles (2021)

Our study aimed to characterise the action mode of <i>N</i>-phenacyldibromobenzimidazoles against <i>C. albicans</i> and <i>C. neoformans</i>. Firstly, we selected the non-cytotoxic most active benzimidazoles based on the structure-activity relationships showing that the group of 5,6-dibromobenzimidazole derivatives are less active against <i>C. albicans</i> vs. 4,6-dibromobenzimidazole analogues (<b>5e</b>-<b>f</b> and <b>5h</b>). The substitution of chlorine atoms to the benzene ring of the <i>N</i>-phenacyl substituent extended the anti-<i>C. albicans</i> action (<b>5e</b> with 2,4-Cl<sub>2</sub> or <b>5f</b> with 3,4-Cl<sub>2</sub>). The excellent results for <i>N</i>-phenacyldibromobenzimidazole <b>5h</b> against the <i>C. albicans</i> reference and clinical isolate showed IC<sub>50</sub> = 8 µg/mL and %I = 100 ± 3, respectively. Compound <b>5h</b> was fungicidal against the <i>C. neoformans</i> isolate. Compound <b>5h</b> at 160-4 µg/mL caused irreversible damage of the fungal cell membrane and accidental cell death (ACD). We reported on chitinolytic activity of <b>5h</b>, in accordance with the patterns observed for the following substrates: 4-nitrophenyl-<i>N</i>-acetyl-β-d-glucosaminide and 4-nitrophenyl-β-d-<i>N</i>,<i>N</i>',<i>N</i>″-triacetylchitothiose. Derivative <b>5h</b> at 16 µg/mL: (1) it affected cell wall by inducing β-d-glucanase, (2) it caused morphological distortions and (3) osmotic instability in the <i>C. albicans</i> biofilm-treated. Compound <b>5h</b> exerted <i>Candida</i>-dependent inhibition of virulence factors.
Video-Mediated Communication (1997)

From the Publisher:
Decades after their introduction, video communication systems are beginning to realize their potential to support working from home, conferencing at a distance, and collaborating and communicating in general. In the face of an upsurge in interest, important questions are being asked: What function does video really serve, and what advantages over the telephone does it provide? How and why is video-mediated interaction different from face-to-face interaction? How can we best configure video technology to support different kinds of work at a distance? What is the role of video technology in the future? People from a variety of disciplines have now produced a substantial body of research addressing these questions from a wide range of analytic perspectives. But their results and conclusions are scattered through journals, conference proceedings, and corporate technical papers. Drawing together the ideas and findings of the major researchers in the field, this volume offers the first comprehensive overview of what we currently know about video-mediated communication. Authors include psychologists, sociologists, anthropologists, engineers, and computer scientists.
Genome-Wide Mapping and Microscopy Visualization of Protein–DNA Interactions by pA-DamID (2022)

Several methods have been developed to map protein-DNA interactions genome-wide in the last decades. Protein A-DamID (pA-DamID) is a recent addition to this list with distinct advantages. pA-DamID relies on antibody-based targeting of the bacterial Dam enzyme, resulting in adenine methylation of DNA in contact with the protein of interest. This <sup>m6</sup>A can then be visualized by microscopy, or mapped genome-wide. The main advantages of pA-DamID are an easy and direct visualization of DNA that is in contact with the protein of interest, unbiased mapping of protein-DNA interactions, and the possibility to select specific subpopulations of cells by flow cytometry before further sample processing. pA-DamID is particularly suited to study proteins that form large chromatin domains or that are part of distinct nuclear structures such as the nuclear lamina. This chapter describes the pA-DamID procedure from cell harvesting to the preparation of microscopy slides and high-throughput sequencing libraries.
Variable message sign and dynamic regional traffic guidance (2009)

Traffic has always been the infrastructure of national economic and social development. With the pace of urbanization unprecedented speedup and the increase of vehicle possessions, traffic congestion has become a big problem in modern cities. Regional traffic guidance system provides traffic information for road travelers in pre-trip and in on-trip, and guides travelers to change travel modes, choose travel routes, and save travel time to take full advantage of road network resources. Variable message sign (VMS) is one of the main ways to provide traffic information in metropolitan road network, but traditional VMS guidance regions are designated manually by traffic administrators to cause very bad effectiveness and efficiency, and there are even some VMS used only for advertising that have nothing to do with the traffic guidance management. We analyze the traffic guidance model based on VMS, and study the dynamic regional partition problem and the dynamic traffic guidance problem under real-time traffic conditions, and put forward the architecture and two algorithms. The architecture serves mainly for the whole cycle of developing VMS based guidance from raw data collection to traffic information publish. The algorithms dynamically partition traffic guidance regions and dynamically change the vehicle turning ratio at intersections to balance traffic flow and save travel time in guidance regions. The cellular automaton method based on SWARM platform is employed to simulate traffic environment, and verify the effectiveness and efficiency of the model and the algorithms by compare with the other traditional regional guidance algorithm.
Bright Polariton Coumarin‐Based OLEDs Operating in the Ultrastrong Coupling Regime (2018)

Abstract Organic microcavities in strong and ultrastrong light–matter coupling regimes allow the exploration of intriguing quantum phenomena, such as Bose–Einstein condensation of exciton‐polaritons, even at room temperature. Nevertheless, electrically driven organic polariton devices have shown so far poor performances, insufficient for practical applications, mainly due to the lack of an effective approach to exploit the molecular properties in order to optimize the population mechanism of polariton states. Here, novel bright polariton organic light‐emitting diodes (OLED) are reported based on a coumarin dye, which showed coupling strengths up to 37%, entering in the ultrastrong coupling regime. Owing to a high molecular emission efficiency, a large Stokes shift, and a fine cavity‐exciton tuning, the radiative pumping mechanism of polariton states has been fully optimized, leading a large portion of excitons to be converted in polariton emission. The resulting polariton OLEDs showed external quantum efficiencies up to 0.2% and maximum luminance of 700 cd m −2 , which are, to the best of our knowledge, the highest values reported so far for this class of devices. Furthermore, the findings give clear indications for an effective exploitation of organic polariton dynamics toward the development of novel optoelectronic devices.
Time-domain reactive power concepts for nonlinear, nonsinusoidal or nonperiodic networks (2002)

Two methods for extending the definition of reactive power beyond the sinusoidal steady state are presented. Reactive power concepts are created that can be useful in the state-space analysis of nonlinear or nonperiodic systems. All definitions and results are given purely in the time domain without using Fourier analysis or other orthogonal function expansions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: SOLVOMERCURATION REACTIONS. XXIII. HASUBANAN DERIVATIVES SYNTHESIS. OPIATE RECEPTORS AFFINITY (1981)

Abstract Das Aminoethylhexahydrophenanthren (II) wird nach Literaturangabe aus dem Tetralon (I) synthetisiert.
A dual polarized UHF/VHF honeycomb stacked-patch array antenna: Overview of an enabling technology for the MOSS mission (2008)

The full-size VHF/UHF antenna feed array prototype for the MOSS radar antenna system was successfully built and tested. The validity of the design and feasibility of constructing such a feed system for a future spaceborne radar that has a 30-m mesh reflector antenna was demonstrated. No road blocks or major remaining challenges were identified, though several potentials for improvement were identified. The feed system prototyped here is expected to provide all characteristics necessary for a spaceborne version of the MOSS radar system.
Sr/sub 2/AlTaO/sub 6//YBa/sub 2/Cu/sub 3/O/sub 7/ heterostructures for superconducting device applications (1993)

Using pulsed laser deposition, the authors have prepared epitaxial heterostructures of a new insulating perovskite Sr/sub 2/AlTaO/sub 6/ (SAT) and the high-temperature superconductor YBa/sub 2/Cu/sub 3/O/sub 7/ (YBCO) on LaAlO/sub 3/ substrates. X-ray rocking curve and Rutherford backscattering channeling measurements on
Response Inhibition and Interference Control in Obsessiveâ€“Compulsive Spectrum Disorders (2014)

Over the past 20 years, motor response inhibition and interference control have received considerable scientific effort and attention, due to their important role in behavior and the development of neuropsychiatric disorders. Results of neuroimaging studies indicate that motor response inhibition and interference control are dependent on cortical-striatal-thalamic-cortical (CSTC) circuits. Structural and functional abnormalities within the CSTC circuits have been reported for many neuropsychiatric disorders, including obsessive-compulsive disorder (OCD) and related disorders, such as attention-deficit hyperactivity disorder, Tourette's syndrome, and trichotillomania. These disorders also share impairments in motor response inhibition and interference control, which may underlie some of their behavioral and cognitive symptoms. Results of task-related neuroimaging studies on inhibitory functions in these disorders show that impaired task performance is related to altered recruitment of the CSTC circuits. Previous research has shown that inhibitory performance is dependent upon dopamine, noradrenaline, and serotonin signaling, neurotransmitters that have been implicated in the pathophysiology of these disorders. In this narrative review, we discuss the common and disorder-specific pathophysiological mechanisms of inhibition-related dysfunction in OCD and related disorders.
Anaerobic botryomycosis (1980)

Botryomycosis ofthe liver developed in a patient receiving corticosteroid therapy. The botyromycosis was caused by Propionibacterium acnes, which grew only anaerobically. The patient was successfully treated medically and at followup is asymptomatic.
Abstract 1890: Chloroquine synergizes with MEK1/2 targeted therapy through dual YAP and lysosomal inhibition in GNAQ/11 mutant uveal melanoma (2020)

Abstract GNAQ and GNA11 (GNAQ/11) mutations are found in less than 2% of all melanoma, but more than 80% of uveal melanoma. Mutations in these Gα proteins lead to constitutive activation of multiple oncogenic pathways, including MAPK (RAF-&amp;gt;MEK1/2-&amp;gt;ERK1/2) and YAP signaling. Metastatic uveal melanoma is refractory to all forms of pharmacologic treatment, such as FDA-approved targeted therapies inhibiting MEK1/2 (i.e. trametinib and binimetinib). We show that combining MEK1/2 inhibitors with 4-aminoquinoline antimalarials, chloroquine or hydroxychloroquine, resulted in synergistic and apoptosis-mediated cytotoxicity in GNAQ/11 mutant uveal melanoma cell lines. Interestingly, in contrast to our previous work in pancreatic and other RAS-driven cancers, the lysosomotropic role of chloroquine was not sufficient to promote cytotoxicity with MEK1/2 inhibitors, as neither lysosome inhibition with Bafilomycin A1 nor autophagy-specific and macropinocytosis-specific inhibition yielded enhanced cell death in combination with MEK1/2 inhibition. We then found that chloroquine prevented nuclear localization of the transcriptional coactivator, YAP, suggesting a novel mechanism of chloroquine. YAP inhibition combined with MEK1/2 inhibition enhanced cell death only in the presence of Bafilomycin A1. Gα-specific inhibition (inhibiting YAP and MAPK) combined with Bafilomycin A1 yielded similar results. This implies that the ability of chloroquine to inhibit both YAP signaling and lysosome function is required for promoting cell death in the presence of MEK1/2 inhibition. For in vivostudies, we utilized a hepatic colonization model using luciferized human metastatic uveal melanoma cell lines, OMM2.5 and OMM1. Daily treatment of trametinib with hydroxychloroquine in combination resulted in delayed tumor growth and increased overall survival compared to either treatment as monotherapy or chemotherapy. These findings were also recapitulated in an immunocompetent mouse model in which immortalized mouse melanocytes (Melan-A) with either a GNAQ or GNA11 activating mutation were implanted into syngeneic C57BL/6 mice. Our findings identify a novel mechanism of chloroquine and suggest a potentially effective strategy combining two FDA-approved drugs for the treatment of metastatic uveal melanoma. Citation Format: Amanda Truong, Michael Scherzer, Conan Kinsey, John Michael Sanchez, Jae Hyuk Yoo, Jackson Richards, Donghan Shin, Phaedra Ghazi, Michael Onken, Kendall Blumer, Shannon Odelberg, Martin McMahon. Chloroquine synergizes with MEK1/2 targeted therapy through dual YAP and lysosomal inhibition in GNAQ/11 mutant uveal melanoma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1890.
Novel and Highly Regio- and Stereoselective Nickel-Catalyzed Homoallylation of Benzaldehyde with 1,3-Dienes (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel and Highly Regio- and Stereoselective Nickel-Catalyzed Homoallylation of Benzaldehyde with 1,3-DienesMasanari Kimura, Akihiro Ezoe, Kazufumi Shibata, and Yoshinao TamaruView Author Information Department of Applied Chemistry Faculty of Engineering, Nagasaki University 1-14 Bunnkyo, Nagasaki 852-8521, Japan Cite this: J. Am. Chem. Soc. 1998, 120, 16, 4033–4034Publication Date (Web):April 14, 1998Publication History Received10 November 1997Published online14 April 1998Published inissue 1 April 1998https://pubs.acs.org/doi/10.1021/ja973847chttps://doi.org/10.1021/ja973847crapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views3247Altmetric-Citations161LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Aldehydes,Alkyls,Mixtures,Molecular structure Get e-Alerts