gebhart/patrepeval huggingface dataset:
Intracerebral hemorrhage, cerebral infarction, and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction Study. Thrombolysis in Myocardial Infarction, Phase II, pilot and clinical trial. (1991)

In the Thrombolysis in Myocardial Infarction, Phase II pilot and clinical trial, 908 patients [326 (35.9%) in the pilot study and 582 (64.0%) in the randomized study] were treated with 150 mg recombinant tissue-type plasminogen (rt-PA) activator in combination with heparin and aspirin, and 3,016 patients [64 (2.1%) in the pilot study and 2,952 (97.9%) in the randomized study] were treated with 100 mg rt-PA in combination with heparin and aspirin. Adverse neurological events occurred in 23 patients treated with 150 mg rt-PA (2.5%) [nine cerebral infarctions (1.0%), 12 intracerebral hemorrhages (1.3%), and two subdural hematomas (0.2%)] and in 33 patients treated with 100 mg rt-PA (1.1%) [20 cerebral infarctions (0.7%), 11 intracerebral hemorrhages (0.4%), and two subdural hematomas (0.1%)]. The difference in adverse neurological events observed comparing the two rt-PA regimens was primarily due to a higher frequency of intracerebral bleeding among patients treated with 150 mg rt-PA (1.3% versus 0.4%, p less than 0.01). Patients with recent (within 6 months) histories of stroke were not eligible for the study, and patients with any history of cerebrovascular disease were declared ineligible early in the study. The small number of patients (89, or 2.3%) with any history of neurological disease, intermittent cerebral ischemic attacks, or stroke who were enrolled before the stricter eligibility criteria were imposed or on the basis of incomplete baseline information experienced an increased frequency of intracerebral hemorrhage compared with patients without such histories (3.4% versus 0.5%). Mortality at 6 weeks after presentation among 23 patients who had intracerebral hemorrhage was 47.8%. Intracerebral hemorrhage is a severe but infrequent complication of rt-PA therapy for acute myocardial infarction. The combined frequency of intracerebral hemorrhage, subdural hematoma, and cerebral infarction after treatment with 100 mg rt-PA is comparable to that observed in other trials with thrombolytic agents in acute myocardial infarction.
The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) (2017)

We examined the prognostic role of PD-1+ and CD8+ tumor infiltrating lymphocytes (TILs), and PD-L1+ cells in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with surgery and postoperative chemoradiotherapy (CRT). FFPE samples from 161 patients were immunohistochemically stained for PD-1, CD8 and PD-L1. The immune marker expression was correlated with clinicopathologic characteristics, and overall survival (OS), local progression-free survival (LPFS) and distant metastases free-survival (DMFS), also in the context of HPV16 DNA/p16 status. The median follow-up was 48 months (range: 4-100). The 2-year-OS was 84.1% for the entire cohort. High PD-1 and PD-L1 expression were more common in patients with positive HPV16 DNA (p < 0.001 and p = 0.008, respectively) and high infiltration by CD8+ TILs (p < 0.001 for both markers). High PD-L1 expression correlated with superior OS (p = 0.025), LPFS (p = 0.047) and DMFS (p = 0.048) in multivariable analysis, whereas no significance could be demonstrated for PD-1. Patients with CD8<sup>high</sup> /PD-L1<sup>high</sup> expression had favorable outcome (p < 0.001 for all endpoints) compared to other groups. We validated the superior OS data on CD8<sup>high</sup> /PD-L1<sup>high</sup> using the Cancer Genome Atlas TCGA dataset (n = 518; p = 0.032). High PD-L1 expression was a favorable prognostic marker in HPV16-negative but not HPV16-positive patients. In conclusion, HPV-positive tumors showed higher expression of immune markers. PD-L1 expression constitutes an independent prognostic marker in SCCHN patients post-adjuvant CRT. In conjunction with CD8 status, these data provide an important insight on the immune contexture of SCCHN and are directly relevant for future treatment stratification with PD-1/PD-L1 immune checkpoint inhibitors to complement CRT.
Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation (2010)

A stereochemical test has been used to probe the mechanism of decarboxylative allylation. This probe suggests that the mechanism of DcA reactions can change based on the substitution pattern at the alpha-carbon of the nucleophile; however, reaction via stabilized malonate nucleophiles is the lower energy pathway. Lastly, this mechanistic proposal has predictive power and can be used to explain chemoselectivities in decarboxylative reactions that were previously confounding.
Effects of Intravenous Fluid Restriction on Postoperative Complications: Comparison of Two Perioperative Fluid Regimens (2003)

The restricted perioperative intravenous fluid regimen aiming at unchanged body weight reduces complications after elective colorectal resection.
Direct bandgap materials based on the thin films of Se x Te100 − x nanoparticles (2012)

In this study, we fabricated thin films of SexTe100 - x (x = 0, 3, 6, 9, 12, and 24) nanoparticles using thermal evaporation technique. The results obtained by X-ray diffraction show that the as-synthesized nanoparticles have polycrystalline structure, but their crystallinity decreases by increasing the concentration of Se. They were found to have direct bandgap (Eg), whose value increases by increasing the Se content. These results are completely different than those obtained in the films of SexTe100 - x microstructure counterparts. Photoluminescence and Raman spectra for these films were also demonstrated. The remarkable results obtained in these nanoparticles specially their controlled direct bandgap might be useful for the development of optical disks and other semiconductor devices.
The influence of O3, relative humidity, NO and NO2 on the oxidation of ? -pinene and ? 3-carene (2003)

The influence of O3, relative humidity, NO and NO2 on the oxidation of ? -pinene and ? 3-carene
An Integrated Course Design Model for Beginning Faculty (2014)

It is rare that faculty members begin their first full-time teaching position with an integrated and consciously constructed practical model for course design, teaching, and learning. The purpose of this article is to offer new faculty members a starting point for constructing an integrated model of the course design and teaching and learning processes. The model begins with the instructor’s choice of course learning goals, objectives, and outcomes and progresses through the translation of those learning goals and objectives into articulated evaluation and feedback rubrics, the choice of specific learning activities and materials reflected in a learner-centered syllabus, the conduct of the in-class activities, and the choices of learning assessments. These elements are highly interactive and iterative, as well as contextualized with respect to such issues as course location in a program, class size, student learning development and diversity, and individual faculty differences. We provide resources and usable examples for new faculty.
Liquid chromatography of phenolic compounds on a microbore anion exchange resin column (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid chromatography of phenolic compounds on a microbore anion exchange resin columnKrishnat P. Naikwadi, Souji. Rokushika, and Hiroyuki. HatanoCite this: Anal. Chem. 1984, 56, 8, 1525–1527Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ac00272a072https://doi.org/10.1021/ac00272a072research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of functionalised N-heterocyclic carbene ligands bearing a long spacer and their use in olefin metathesis (2013)

A synthetic route to backbone functionalised imidazolinium salts-NHC ligand precursors has been developed. These tagged NHC ligands can be used to obtain a homogeneous Hoveyda-type catalyst (19) containing a quaternary ammonium group on a C-8 long spacer. Products of olefin metathesis reactions promoted by complex 19 can be readily purified from Ru-residues by filtration of the reaction mixture through a small amount of silica gel.
Development of Oxidative Formylation and Ketonylation Reactions (2010)

The first oxidative formylation and oxidative ketonylation of alkenylamines and alkenyl alcohols is demonstrated. A range of substrates that participate in this process are provided. Oxidative formylation was found to proceed optimally with the use of triphenylsilane as the hydride source. Oxidative ketonylation was feasible with a number of organometallic partners, especially dialkylzinc or organostannanes. An interesting finding regarding the fate of various acylpalladium intermediates is discussed.
Erratum: Energy levels of interacting curved nanomagnets in a frustrated geometry: increasing accuracy when using finite difference methods (2013)

International audience
Salvage Chemotherapy with R-DHAP in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma (2016)

This analysis reports on 72 patients with relapsed or refractory non-Hodgkin lymphoma who were treated with R-DHAP salvage chemotherapy regimen followed by high-dose chemotherapy and stem cell transplantation. The overall remission rate was 58.3%. Median time of follow-up was 28.7 months. Median progression-free survival was 29 months, estimated median overall survival was 37 months. Within a matched pair analysis these results were compared to a group that received DHAP salvage therapy without rituximab showing similar overall response rates and better estimated five-year overall survival of 59.2% versus 43.5%. R-DHAP therapy was shown to be effective and feasible with acceptable toxicity.
Oncolytic measles viruses for cancer therapy (2004)

New strategies using biological agents are being developed to treat cancer. Live viruses are among these new agents. Virotherapy uses replication-competent viral vectors with strong oncolytic properties. With the use of molecular virology techniques, viruses have been genetically engineered to replicate selectively in tumour cells and are under preclinical and clinical investigation at present. Measles virus (MV) is being used for this purpose. Replication-competent attenuated Edmonston B measles vaccine strain (MV-Edm) is non-pathogenic and has potent antitumour activity against several human tumours. The virus is selectively oncolytic in tumour cells, eliciting extensive cell-to-cell fusion and ultimately leading to cell death. Therefore, MV-Edm is a safe and efficient means to kill tumour cells. Further improvements in existing MV vectors may increase tumour selectivity and oncolytic activity. This review discusses the discovery and development of replication-competent oncolytic MV for cancer therapy.
A New Assessment of the Performance of Low-noise Organic Photodetectors (2021)

An improved characterization of organic photodiode performance enables a reassessment of electronic noise and optimization of large-area organic photodetectors that at visible wavelengths are comparable to low-noise silicon photodiodes in all metrics except response time.
Returns to Farmland Investment in Alberta, 1964-1989 (1993)

The objective of this study was to analyze the performance of Alberta farmland relative to investment opportunities from financial securities. It is an extension of an earlier study undertaken by Mercier (1988) and Phillips et al. (1989). This study re-examines the period from 1964 to 1985, and extends the data series to 1989. The results show that Alberta farmland out performed the stock market in both nominal and real terms, but with greater volatility. In nominal terms, farmland had an annual return of 19.8% as opposed to 12.2% in the stock market. The standard deviation of returns in farmland was 20.6% compared to 16.2%. The real return for farmland was 12.6% whereas the stock market earned 5.9%. About 55% of the total return to investment in Alberta farmland was due to capital gain; measured in real terms, income accounted for the major portion at about 66%. Farmland and stock market returns were found to be uncorrelated in both nominal and real terms. Beta values, which measure the degree of association, were estimated at -0.1632 and -0.1351 for nominal and real terms respectively. Neither nominal nor real beta values were significantly different from zero at the 5% probability level. These results are not inconsistent with earlier studies, and are attributed to the fact that returns in agriculture are subject to a different set of economic and environmental influences than are present for the stock market generally. This suggests possibilities for risk reduction by including stock market investments in conjunction with farmland ownership. Whereas no correlation was found between farmland and the stock market, returns in excess of what can be explained by compensation for risk were detected. The estimated alpha values of 11.27% and 10.21% for the nominal and real situations were significantly different from zero at the 5% level of probability. These values may be due, partially, to the fact that real estate taxes were not deducted in computing the results. Furthermore, the costs of administration in farmland investments, because of the much less formal market environment in which they are held, may be considerably greater than for the stock market. In addition,' stock market investments are considerably more divisible and liquid than is the farmland counterpart. Factors such as these bear further study.
AIRCRAFT DATA NETWORKS - INTEGRATED SYSTEM (2011)

Aircraft data networks are fast becoming more of a necessity due to their support for user mobility. Many aircraft manufacturers are planning to deploy data networks within their airplanes and provide internet connectivity to their passengers. While a data network within the aircraft and passenger access to it causes some security concerns, it open up some safety enhancement opportunities. With internet connectivity within the airplane, the activity within the airplane can be monitored in real-time from the ground station. Also, using the high bandwidth satellite links, the flight critical data could be downloaded to a server in the ground station in real-time flight or periodically, thereby enabling real-time flight status monitoring.
Burkitt Lymphoma Presenting as an Intracardiac Mass: Case Report and Review of Literature (2016)

BACKGROUND Non-neoplastic causes such as infections and thrombi account for most intracardiac masses. Primary tumors such as myxomas and metastasis from breast cancer, lung cancer, or melanomas account for many of the remaining cases. Burkitt lymphoma manifesting as an intracardiac mass is a rare entity, with 21 cases reported in the English literature. CASE REPORT We report the case of a man infected with human immunodeficiency virus (HIV) who presented with non-specific cardiac symptoms and was later found to have intracardiac mass caused by Burkitt lymphoma. His rapid decline with unexpected complications was reversed with prompt management. Subsequent to induction, the patient achieved a near complete response with considerable improvement in his condition. CONCLUSIONS Lymphoma should be considered in the differential diagnosis of intracardiac masses. Associated cardiac symptoms are frequently non-specific and can often be overlooked or underappreciated. Burkitt lymphoma has a short doubling time and an intracardiac lesion can become life-threatening in a matter of days. Early recognition and prompt treatment are crucial to achieving optimal outcomes.
Crystallization and preliminary X‐ray analysis of fructose 6‐phosphate, 2‐kinase:fructose 2,6‐bisphosphatase (1995)

Diffraction-quality crystals of the bifunctional enzyme fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase from rat testis have been obtained. The crystals were grown in the presence of ATP gamma S, fructose 6-phosphate, the detergent n-octylglucoside, and the precipitant polyethylene glycol 4000. The crystals have the symmetry of the trigonal space group P31/221 with a = b = 83.0 A and c = 130.6 A. Flash-frozen crystals diffract to beyond 2.2 A, and native data have been collected.
Involvement of ammonia metabolism in the improvement of endurance performance by tea catechins in mice (2020)

Blood ammonia increases during exercise, and it has been suggested that this increase is both a central and peripheral fatigue factor. Although green tea catechins (GTCs) are known to improve exercise endurance by enhancing lipid metabolism in skeletal muscle, little is known about the relationship between ammonia metabolism and the endurance-improving effect of GTCs. Here, we examined how ammonia affects endurance capacity and how GTCs affect ammonia metabolism in vivo in mice and how GTCs affect mouse skeletal muscle and liver in vitro. In mice, blood ammonia concentration was significantly negatively correlated with exercise endurance capacity, and hyperammonaemia was found to decrease whole-body fat expenditure and fatty acid oxidation-related gene expression in skeletal muscle. Repeated ingestion of GTCs combined with regular exercise training improved endurance capacity and the expression of urea cycle-related genes in liver. In C2C12 myotubes, hyperammonaemia suppressed mitochondrial respiration; however, pre-incubation with GTCs rescued this suppression. Together, our results demonstrate that hyperammonaemia decreases both mitochondrial respiration in myotubes and whole-body aerobic metabolism. Thus, GTC-mediated increases in ammonia metabolism in liver and resistance to ammonia-induced suppression of mitochondrial respiration in skeletal muscle may underlie the endurance-improving effect of GTCs.
LQ Control without Riccati Equations: Stochastic Systems (1999)

We study stochastic linear--quadratic (LQ) optimal control problems over an infinite horizon, allowing the cost matrices to be indefinite. We develop a systematic approach based on semidefinite programming (SDP). A central issue is the stability of the feedback control; and we show this can be effectively examined through the complementary duality of the SDP. Furthermore, we establish several implication relations among the SDP complementary duality, the (generalized) Riccati equation, and the optimality of the LQ control problem. Based on these relations, we propose a numerical procedure that provides a thorough treatment of the LQ control problem via SDP: it identifies a stabilizing feedback control that is optimal or determines that the problem possesses no optimal solution. For the latter case, we develop an ε-approximation scheme that is asymptotically optimal.
Lower extremity: nonstepping digital angiography with photostimulable imaging plates versus conventional angiography. (1998)

Nonstepping DSA images of the lower extremity were of better diagnostic quality than were screen-film angiograms. The development of dedicated nonstepping DSA equipment is warranted.
Early prediction of renal allograft loss beyond one year (1993)

Despite significant improvements in the results of renal transplantation since the introduction of cyclosporin, graft loss beyond the 1st year remains a significant and unresolved problem. In a retrospective analysis, 348 cyclosporin-treated renal transplant recipients with a functioning graft at 12 months were studied. Forty-eight patients in whom graft failure occurred in the 2nd and 3rd years were compared to 300 patients who maintained graft function beyond this time. Both groups were comparable with respect to donor and recipient features. Factors reflecting recipient immunological responsiveness--sensitization, previous transplantation and early rejection episodes--continued to affect graft survival beyond the 1st year. Surprisingly, there was a higher incidence of prior transfusion in the group with graft failure in the 2nd and 3rd years than in those with longer function (65% vs 24%). Serum creatinine levels at 3 and 6 months were also predictive of graft loss amongst patients with a functional graft at 1 year. It remains to be answered whether new immunosuppressive drugs and strategies will overcome these risks for late graft loss.
Particulate and Trace Gas Emissions from Open Burning of Wheat Straw and Corn Stover in China (2007)

Field measurements were conducted to determine particulate emissions and trace gas emissions, including CO2, CO, CH4, NMHCs, NOx, NH3, N2O, and SO2, from open burning of wheat straw and maize stover, two major agricultural residues in China. The headfire ignition technique was adopted, and sampling was performed downwind from the agricultural fire. Particulate matter (PM) and gas emission factors were determined using the carbon mass-balance method. Particle mass size distributions show a prominent accumulation mode peak at 0.26-0.38 microm. Submicron particles dominate PM emissions. Most measured chemical species measured show a similar size distribution as PM. Chemical composition analysis indicates that PM2.5 is largely composed of carbon, K, and Cl. PM2.5 emission factors of wheat straw and maize stover are 7.6 +/- 4.1 g/kg and 11.7 +/- 1.0 g/kg, respectively, It also indicates that 12.1-24.2% of N in biomass is released as nitrogen-based trace gases and 11.0-24.9% of fuel S is emitted as SO2.
Addition of 2‐Oxazolidinones to Arylidenecyclopropanes: A Highly Efficient Method for the Preparation of gem‐Aryl Disubstituted Homoallylic Oxazolidinones. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.