gebhart/patrepeval huggingface dataset:
Plant-based vaccines against viruses (2014)

Plant-made or "biofarmed" viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.
Impact of radial force nonlinearities on decentralized control of magnetic bearings (2010)

This paper describes impact of nonlinearities of the radial force on decentralized control of active magnetic bearings (AMBs). Two cases with different design are analyzed; one with a considerable impact of magnetic nonlinearities, and other with almost linear magnetic properties. The current and position-dependent radial forces are determined by finite element computation over the entire operating range. The obtained radial force characteristics are incorporated into the proposed dynamic AMB model. The presented results show that nonlinearities of radial force deteriorate dynamic behavior of the closed-loop system; moreover, operating range of the AMB is considerably reduced.
Beam‐centric algorithm for pretreatment patient position correction in external beam radiation therapy (2010)

The algorithm achieves improvements in delivery accuracy using standard delivery hardware without significantly increasing total treatment session duration. It encourages parsimonious utilization of all available DOF. Finally, in certain cases, it obviates the need of a robotic couch having six DOF for the correction of patient displacement and rotations.
Management of persistent postpartum pelvic pain. (2008)

Persistent postpartum pelvic pain is an uncommon but disabling disorder. Although symptoms resolve spontaneously in the majority of cases, some carefully selected women with this chronic condition might benefit from surgical stabilization of the pelvic ring. We retrospectively studied 19 patients whose persistent postpartum pelvic pain was treated at our center. Although most patients were successfully treated nonoperatively, 6 (31.5%) underwent surgery because of symptoms persisting more than 1 year. Imaging studies, including magnetic resonance imaging, were used to assess the extent and the nature of the lesion before surgery. Eleven patients had degenerative changes in the anterior pelvic ring; the other 8 patients had degenerative sacroiliac joint changes. Surgical procedures included resection of the diseased fragment, anterior symphyseal plating, and bone grafting with and without posterior ring stabilization. For all patients, mean Majeed outcome score was 85 (range, 46-100). No significant difference in outcomes was found between the surgically treated patients and the nonoperatively treated patients.
Role of liver biopsy in management of chronic hepatitis C: A systematic review (2002)

This systematic review addresses 2 questions pertinent to the need for pretreatment liver biopsy in patients with chronic hepatitis C: how well do liver biopsy results predict treatment outcomes for chronic hepatitis C? How well do biochemical blood tests and serologic measures of fibrosis predict the biopsy findings in chronic hepatitis C? Medline and other electronic databases were searched from January 1985 to March 2002. Additional articles were sought in references of pertinent articles and recent journals and by querying experts. Articles were eligible for review if they reported original human data from a study that used virological, histological, pathologic, or clinical outcome measures. Paired reviewers assessed the quality of each eligible study and abstracted data. Studies suggested that advanced fibrosis or cirrhosis on initial liver biopsy is associated with a modestly decreased likelihood of a sustained virological response (SVR) to treatment. Also, studies relatively consistently showed that serum aminotransferases have modest value in predicting fibrosis on biopsy; that extracellular matrix tests hyaluronic acid and laminin may have value in predicting fibrosis, and that panels of tests may have the greatest value in predicting fibrosis or cirrhosis. Biochemical and serologic tests were best at predicting no or minimal fibrosis, or at predicting advanced fibrosis/cirrhosis, and were poor at predicting intermediate levels of fibrosis. Thus, evidence suggests that liver biopsy may have some usefulness in predicting efficacy of treatment in patients with chronic hepatitis C, and biochemical blood tests and serologic tests currently have only modest value in predicting fibrosis on liver biopsy. (Hepatology 2002;36:S161-S172).
Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene (2017)

A huge number of G-rich sequences forming quadruplexes are found in the human genome, especially in telomeric regions, UTRs, and the promoter regions of a number of genes. One such gene is GRIN1 encoding the NR1 subunit of the N-methyl-d-aspartate receptor (NMDA). Several lines of reports have implicated that attenuated function of NMDA results in schizophrenia, a genetic disorder characterized by hallucinations, delusions, and psychosis. Involvement of the GRIN1 gene in the pathogenesis of schizophrenia has been extensively analysed. Recent reports have demonstrated that polymorphism in the promoter region of GRIN1 at position -855 (G/C) has a possible association with schizophrenia. The binding site for the NF-κB transcription factor gets altered due to this mutation, resulting in reduced gene expression as well as NMDA activity. By combining gel electrophoresis (PAGE), circular dichroism (CD) and CD melting techniques, the G → C single nucleotide polymorphism (SNP) at the G-rich sequence (d-CTTAGCCCGAGGAG[combining low line]GGGGGTCCCAAGT; GRIN1) was investigated. We report that the GRIN1 sequence can form an octameric/multistranded quadruplex structure with parallel conformation in the presence of K<sup>+</sup> as well as Na<sup>+</sup>. CD and gel studies are in good correlation in order to detect molecularity and strand conformation. The parallel G-quadruplex species was hypothesized to be octameric in K<sup>+</sup>/Na<sup>+</sup> salts. The mutated sequence (d-CTTAGCCCGAGGAC[combining low line]GGGGGTCCCAAGT; GRIN1M) remained single stranded under physiological conditions. CD melting studies support the formation of an interstranded G-quadruplex structure by the GRIN1 sequence. Two structural models are propounded for a multistranded parallel G-quadruplex conformation which might be responsible for regulating the gene expression normally underlying memory and learning.
Enhancing commercial grammar-based applications using robust approaches to speech understanding (2007)

This paper presents a series of measurements of the accuracy of speech understanding when grammar-based or robust approaches are used. The robust approaches considered here are based on statistical language models (SLMs) with the interpretation being carried out by phrase-spotting or robust parsing methods. We propose a simple process to leverage existing grammars and logged utterances to upgrade grammar-based applications to become more robust to out-of-coverage inputs. All experiments herein are run on data collected from deployed directed dialog applications and show that SLM-based techniques outperform grammar-based ones without requiring any change in the application logic.
Synthesis of Glycidyl‐5‐(carboxyethyl‐1H‐tetrazole)polymer and 1,2‐Bis(5‐carboxyethyl‐1H‐tetrazolyl)ethane as Polymeric Precursor (2012)

Abstract The synthesis of the nitrogen‐rich glycidyl‐5‐(carboxyethyl‐1 H ‐tetrazole)polymer ( 4 ) by the reaction of glycidyl azide polymer (GAP) and ethyl cyanoformate ( 2 ) is described. Moreover, the polymer precursor 1,2‐bis(5‐carboxyethyl‐1 H ‐tetrazolyl)ethane ( 3 ), containing two tetrazole moieties, was obtained by reacting compound 2 and 1,2‐diazidoethane ( 1 ). The substances were characterized by using vibrational spectroscopy (IR), mass spectrometry, as well as multinuclear NMR spectroscopy. Compound 3 was additionally characterized by single‐crystal X‐ray diffraction measurements. The thermal stability of 3 was determined by differential scanning calorimetry, which reveals that this compound is a highly stable molecule.
Improvement of persistent magnetic field trapping in bulk Y-Ba-Cu-O superconductors (1993)

For type-II superconductors, magnetic field can be trapped due to persistent internal supercurrent. Quasi-persistent magnetic fields near 2 T at 60 K (and 1.4 T at 77 K) have been measured in minimagnets made of proton-irradiated melt-textured Y-Ba-Cu-O (MT-Y123) samples. Using the trapping effect, high-field permanent magnets with dipole, quadrupole, or more complicated configurations can be made of existing MT-Y123 material, thus bypassing the need for high-temperature superconductor (HTS) wires. A phenomenological current model has been developed to account for the trapped field intensity and profile in HTS samples. This model is also a guide to select directions of materials development to further improve field trapping properties. General properties such as magnetic field intensities, spatial distributions, stabilities, and temperature dependence of trapped field are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Providing quality of service over a shared wireless link (2001)

We propose an efficient way to support quality of service of multiple real-time data users sharing a wireless channel. We show how scheduling algorithms exploiting asynchronous variations of channel quality can be used to maximize the channel capacity (i.e., maximize the number of users that can be supported with the desired QoS).
ID1/ID3 Mediate the Contribution of Skin Fibroblasts to Local Nerve Regeneration Through Itga6 in Wound Repair (2021)

Abstract Cutaneous wound healing requires intricate synchronization of several key processes. Among them, local nerve regeneration is known to be vitally important for proper repair. However, the underlying mechanisms of local nerve regeneration are still unclear. Fibroblasts are one of the key cell types within the skin whose role in local nerve regeneration has not been extensively studied. In our study, we found skin fibroblasts were in tight contact with regenerated nerves during wound healing, while rare interactions were shown under normal circumstances. Moreover, skin fibroblasts surrounding the nerves were shown to be activated and reprogrammed to exhibit neural cell-like properties by upregulated expressing inhibitor of DNA binding 1 (ID1) and ID3. Furthermore, we identified the regulation of integrin α6 (Itga6) by ID1/ID3 in fibroblasts as the mechanism for axon guidance. Accordingly, transplantation of the ID1/ID3-overexpressing fibroblasts or topical injection of ID1/ID3 lentivirus significantly promoted local nerve regeneration and wound healing following skin excision or sciatic nerve injury. Therefore, we demonstrated a new role for skin fibroblasts in nerve regeneration following local injury by directly contacting and guiding axon regrowth, which might hold therapeutic potential in peripheral nerve disorders and peripheral neuropathies in relatively chronic refractory wounds.
Contribution à la modélisation et la commande robuste de robots manipulateurs à articulations flexibles. Applications à la robotique interactive. (2013)

The present thesis addresses the problem of motion control of flexible-joint robot manipulators using motor sensors only. The global objective is to guarantee tracking performance and robustness with respect to modeling uncertainties, together with safe human-robot interaction in a collaborative scenario where the robot and the human operator share the same workspace. The first objective of performance is achieved through the experimental identification of a flexible model of the system and the use of this model for the design of advanced control laws implemented in a cascade structure. Two complementary approaches, based either on predictive (Generalized Predictive Control, GPC) or Hinfinity control frameworks, are considered to design predictive and robust two degrees-of-freedom controllers. Experimental evaluation and analysis of the proposed strategies is provided. The second objective of safety is addressed by a novel algorithm for human-robot collision detection, without force sensors and in the presence of modeling uncertainties. In order to efficiently separate the dynamic effects of the collisions from the effects due to modeling errors, the proposed approach includes adaptive filtering and uses dynamic thresholds depending on the robot state. Experimental evaluation demonstrates a good detection sensitivity which is consistent with safety standards and recommendations for collaborative robotics.
Configuration of SoA-based devices in virtual production cells (2011)

Abstract The field of factory automation has been the target of many recent research efforts related to improving overall efficiency and reconfigurability in order to effectively enable the advent of mass customisation. These efforts have promoted the adoption of autonomous, loosely-coupled devices aimed at simplifying the integration of modular production cells, as well as new production control methodologies which aim to bring efficiency, agility and quick turnaround to the production process. As these new production paradigms start to trickle down to the factory floor, a new set of tools must be developed in order to support their implementation. Recent advances in computing power and functionality from the past decades have opened up the opportunity to not only improve the processing capabilities within control devices but to implement engineering tools which will support the systems engineers in building the modular production floor. This paper presents the development of such a tool which facilitates the implementation of said devices, and their functionalities which aim to simplify the configuration and layout of modular, service-oriented devices in a virtual production line. The tool can then be used as a simulation platform in order to test out different layouts and production processes. Keywords: CADmanufacturing systems engineeringreconfigurable manufacturing systemssimulationvirtual cells Acknowledgements The authors would like to thank the European Commission and the partners of the EU IST FP6 project ‘Service-Oriented Cross-layer infrastructure for Distributed smart Embedded devices’ (SOCRADES) and the EC ICT FP7 NoE project ‘Cooperating Objects’ (CONET) for their support.
Silicon-on-insulator-based photonic-crystal Mach-Zehnder interferometers (2006)

Si nanophotonics is anticipated to play a critical role in the future ultra-compact system integration due to the maturity of sub-micron silicon complementary metal oxide semiconductor (CMOS) technology. Photonic crystals (PhCs) provide a promising platform for developing novel optoelectronic devices with significantly reduced device size and power consumption. The active control of photonic crystal waveguides (PCWs) incorporated in Mach-Zehnder interferometers has been investigated in this paper. We designed and fabricated a PCW based silicon thermo-optic (TO) switch operating at 1.55 &mu;m. A novel device structure was proposed to enhance the heat exchange efficiency between the source and the active PCW region, which resulted in a faster switching time (< 20&mu;s) compared with the conventional structure. The required &#960; phase shift between the two arms of the MZI has been successfully achieved within an 80 &mu;m interaction distance. The maximum modulation depth of 84% was demonstrated for switching power of 78mW. For high-speed applications, a p-i-n structure based PCW electro-optical (EO) MZI modulator was proposed. The transient performance of such a device was evaluated using a two-dimensional semiconductor device simulator MEDICI. The simulated structure demonstrated a great potential to realize high-speed ultra-compact Si modulators in the GHz region.
Growth Hormone Binding Proteins and Various Forms of Growth Hormone: Implications for Measurements (1990)

GH measurements are complicated by numerous physiologically occurring GH forms, by the lack of availability of completely specific reagents for the various GH isoforms, and by interference of the circulating BP in some assays. The discrepancies between assay results are partly due to these factors, with monoclonal immunoassays or RRAs being more affected than polyclonal immunoassays.
Dynamic Sparse Sampling for Confocal Raman Microscopy (2018)

The total number of data points required for image generation in Raman microscopy was greatly reduced using sparse sampling strategies, in which the preceding set of measurements informed the next most information-rich sampling location. Using this approach, chemical images of pharmaceutical materials were obtained with >99% accuracy from 15.8% sampling, representing an ∼6-fold reduction in measurement time relative to full field of view rastering with comparable image quality. This supervised learning approach to dynamic sampling (SLADS) has the distinct advantage of being directly compatible with standard confocal Raman instrumentation. Furthermore, SLADS is not limited to Raman imaging, potentially providing time-savings in image reconstruction whenever the single-pixel measurement time is the limiting factor in image generation.
The Non-Government Force in the IPR Protection of Software (2010)

Software is cheap,easily-copied and variable in terms of its features,which makes its IPR protection only by the government more difficult. However,the non-government force plays its dual role in this aspect as infringer and creator ; individually it is weak but collectively it is strong. With the reaction of suit ,it functions widely,unstably and unconsciously. The paper gives the following suggestions for maximizing its function:There should be further improvement of the legislation and legal protection for software IPR; there should be more effective IPR implementation and awareness. Besides,it is important to bring the full functions of the software association as a non-government force into full play in order to ensure effective software IPR protection with better protection consciousness of the common people.
A Molecular Simulation Study on Adsorption of Acetone/Water in Mesoporous Silicas Modified by Pore Surface Silylation (2005)

Two types of molecular simulation techniques have been utilized to investigate surface modification effects on adsorption of acetone/water in mesoporous silicas with a hexagonal uniform pore structure: the NVT-ensemble Molecular Dynamics technique with the melt-quench algorithm for modeling a non-silylated mesoporous silica (an OH surface model) and a fully silylated mesoporous silica (an FS surface model), and the μVT-ensemble Orientational-Bias Monte Carlo method for calculating adsorption isotherms. A good agreement was obtained between simulations and experiments for adsorption of pure acetone and water at 298 K on non-silylated and silylated mesoporous silicas. Equilibrium adsorption densities of the equi-fugacity mixture of acetone and water are calculated for the OH and FS surface models, by specifying either the gas or the liquid phase for the mixture. A considerably large separation factor, 7300, was obtained for the adsorption from a liquid mixture in the FS surface model, though the adsorption amount was rather small, which explains why the pervaporation through highly silylated mesoporous silica membranes was effective for separation of organic/water mixtures.
Availability analysis of railway track circuits (2010)

Railways are expected to operate with ever increasing availability. The availability of railway systems and subsystems influences the overall operational availability. As the track circuit is a key component of railway signalling and control, it can contribute significantly to the loss of availability of the railway system. One way to increase the availability of the track circuit is by implementing a proper maintenance policy. In this article, Petri-nets have been used to develop models for availability analysis of the track circuit for both time-based and condition-based maintenance. A sensitivity analysis has been performed to estimate the effect of maintenance parameters on availability performance using cost—benefit analysis.
Brush-First and ROMP-Out with Functional (Macro)monomers: Method Development, Structural Investigations, and Applications of an Expanded Brush-Arm Star Polymer Platform (2018)

The efficient synthesis of complex functional polymeric nanomaterials is often challenging. Ru-initiated ring-opening metathesis polymerization (ROMP) of multivalent macromonomers followed by cross-linking to form brush-arm star (BASP) polymers enables access to well-defined nanostructures with diverse functionality. This "brush-first" method leaves active Ru in the BASP microgel core, which could potentially be used in a subsequent "ROMP-out" (RO) step to introduce further modifications to the BASP structure via the addition of (macro)monomers. Here, we study this RO approach in depth. The efficiency of RO is assessed for a variety of BASP compositions using a combination of inductively coupled plasma mass spectrometry and gel permeation chromatography. To demonstrate the modularity of the RO process, arylboronic acid-functionalized BASPs were prepared; uptake of these RO-BASPs into hypersialylated cancer cells was enhanced relative to non-functionalized BASPs as determined by flow cytometry and fluorescence microscopy. In addition, the self-assembly of miktoarm BASPs prepared via brush-first and RO with different macromonomers is demonstrated. The combination of brush-first ROMP with RO provides a simple, modular strategy for access to a wide array of functional nanomaterials.
Genome-Wide TDT Analysis in French-Canadian Families with Tourette Syndrome (2010)

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Allergen Extract of Horse Hair and Dandruff. Quantitative Immunoelectrophoretic Characterization of the Antigens (1976)

Freeze-dried extract of horse hair and dandruff was obtained by extraction, centrifugation, dialysis and freeze-drying. Quantitative immunoelectrophoresis using rabbit antibodies revealed the extract to be composed of 25 antigens of which some were mutually partial identical; 4 were serum-specific and non showed partial identity to solubilized hair proteins. Partial identity to antigens to serum and extract from hair and dandruff of cow, dog, cat, guinea pig, and of extract from house duct was demonstrated. After subjecting the extract to dialysis, ultrafiltration, freeze-drying and storage below 37degreesC for not more than 24 h the antigenic stability and the allergenic activity were unaffected. The effect of enzymatic degradation of the individual proteins with regard to antigenic stability and allergenic activity was also examined.