gebhart/patrepeval huggingface dataset:
Node resource management for DSP applications on 3D Network-on-Chip architecture (2009)

Emerging DSP applications have different latency, energy consumption and quality of service (QoS) requirements. An implementation of such applications requires a large number of intellectual property (IP) cores, communicating with each other, meeting the energy and latency constraints. Network-on-chip (NoC) architectures is able to accommodate a large number of IP cores in the same chip implementing a set of complex applications. This leads to different usage of the available buffer space in the routers of the NoC system. In this work we propose power and the systematic design of novel NOC-based architectures, which realize DSP applications. Additionally, we present an integrated node resource management technique that combines priority assignment and buffer sizing so that the NoC system to best serve requirements of the considered Finally, to best of our knowledge, the implementation of DSP applications in 3D NOC architectures took place for first time. DSP applications. The proposed approach has been evaluated both on 2D and 3D mesh topologies by employing an NoC simulator and four real DSP/multimedia applications gaining an average of 34% on energytimesdelay product for each application. Finally, to best of our knowledge, the implementation of DSP applications in 3D NOC architectures took place for first time.
Center of mass location and segment angular orientation of below-knee-amputee and able-bodied children during walking. (1992)

This investigation compared the center of mass (COM) locations and segment angular orientations of the gait of below-knee-amputee (BKA) children to those of able-bodied (AB) children. Eleven AB children (mean age, 8.4 years) and three BKA children (mean age, 7.5 years) volunteered to participate as subjects. Film data (100 frames per second) of a typical walking stride, were collected for the children during four experimental sessions held at six-month intervals. Two 16mm cameras were used to obtain frontal and lateral views of the subjects. The same approximate rate of walking (1.2m/s +/- 10%) was enforced for all testing sessions and at least three trials of data were collected for each subject during each session. Segmental endpoints of each subject from the film of each camera were digitized and the direct linear transformation (DLT) method was used to obtain three-dimensional segmental location-time data for a complete stride. These data were then used to determine whole body COM locations and angular orientations for the segments. Discrete values describing normalized locations at touchdown, midsupport, and takeoff were determined for whole body COM and the angular orientation of the trunk, thighs, and legs. In the sagittal plane the COM was lower and more anterior for the BKA children when compared to that of the AB children. This was primarily due to the greater forward flexion of the trunk.(ABSTRACT TRUNCATED AT 250 WORDS)
Sparkle: Optimizing Spark for Large Memory Machines and Analytics (2017)

Spark is an in-memory analytics platform that targets commodity server environments today. It relies on the Hadoop Distributed File System (HDFS) to persist intermediate checkpoint states and final processing results. In Spark, immutable data are used for storing data updates in each iteration, making it inefficient for long running, iterative workloads. A non-deterministic garbage collector further worsens this problem. Sparkle is a library that optimizes memory usage in Spark. It exploits large shared memory to achieve better data shuffling and intermediate storage. Sparkle replaces the current TCP/IP-based shuffle with a shared memory approach and proposes an off-heap memory store for efficient updates. We performed a series of experiments on scale-out clusters and scale-up machines. The optimized shuffle engine leveraging shared memory provides 1.3x to 6x faster performance relative to Vanilla Spark. The off-heap memory store along with the shared-memory shuffle engine provides more than 20x performance increase on a probabilistic graph processing workload that uses a large-scale real-world hyperlink graph. While Sparkle benefits at most from running on large memory machines, it also achieves 1.6x to 5x performance improvements over scale out cluster with equivalent hardware setting.
THE SMOOTH PARTICLE VARIABLE STRUCTURE FILTER (2012)

In this paper, a new state and parameter estimation method is introduced based on the particle filter (PF) and the smooth variable structure filter (SVSF). The PF is a popular estimation method, which makes use of distributed point masses to form an approximation of the probability distribution function (PDF). The SVSF is a relatively new estimation strategy based on sliding mode concepts, formulated in a predictor-corrector format. It has been shown to be very robust to modeling errors and uncertainties. The combined method, referred to as the smooth particle variable structure filter (SPVSF), utilizes the estimates and state error covariance of the SVSF to formulate the proposal distribution which generates the particles used by the PF. The SPVSF method is applied on two computer experiments, namely a nonlinear target tracking scenario and estimation of electrohydrostatic actuator parameters. The results are compared with other popular Kalman-based estimation methods.
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives (1992)

N-Oxaloglycine (3) is an alpha-ketoglutarate (1) analogue that is a competitive inhibitor of prolyl 4-hydroxylase (EC 1.14.11.2). A study of the structure-activity relationships of some other oxalo derivatives shows that substitution on the glycine moiety modulates activity stereoselectively and that if the omega-carboxylate is homologated or replaced by either acylsulfonamides or anilide, then activity is sharply reduced. This sensitivity to these changes is contrasted with the relative insensitivity of another putative alpha-ketoglutarate analogue, pyridine-2,5-dicarboxylic acid (2), and the implication is discussed that compounds of both series are unlikely to bind to prolyl hydroxylase in the same way even though both inhibit the enzyme competitively.
Distributed design of network codes for wireless multiple unicasts (2008)

Previous results on network coding for low-power wireless transmissions of multiple unicasts rely on opportunistic coding or centralized optimization to reduce the power consumption. This paper proposes a distributed strategy for reducing the power consumption in a network coded wireless network with multiple unicasts. We apply a simple network coding strategy called ldquoreverse carpooling,rdquo which uses only XOR and forwarding operations. In this paper, we use the rectangular grid as a simple network model and attempt to increase network coding opportunities without the overhead required for centralized design or coordination. The proposed technique designates ldquoreverse carpooling linesrdquo analogous to a collection of bus routes in a crowded city. Each individual unicast then chooses a route from its source to its destination independently but in a manner that maximizes the fraction of its path spent on reverse carpooling lines. Intermediate nodes apply reverse carpooling opportunistically along these routes. Our network optimization attempts to choose the reverse carpooling lines in a manner that maximizes the expected power savings with respect to the random choice of sources and sinks.
Targeted Radiotherapy for Prostate Cancer with an Oncolytic Adenovirus Coding for Human Sodium Iodide Symporter (2009)

These results suggest that oncolytic adenovirus-mediated targeted radiotherapy might be a potentially useful option for enhancing the efficacy or adenoviral virotherapy.
An Optically Isolated Hybrid Two-Stage Current Transformer for Measurements at High Voltage (2006)

The development of a high-voltage (HV) current measurement system for on-site/in-situ calibrations in power systems is described in the paper. The system is based on an optically isolated hybrid two-stage current transformer with electronic circuitry that performs A/D conversion. It uses a fiber optic link for data transmission to a ground station and a laser-driven fiber optic link for supplying power to the electronic circuitry of the remote module at HV. The uncertainty of the current-ratio measurement is estimated to be less than 100/spl middot/10/sup -6/ both in-phase and quadrature.
Approximation of the distribution of a stationary Markov process with application to option pricing (2007)

We build a sequence of empirical measures on the space D(R_+,R^d) of R^d-valued càdlàg functions on R_+ in order to approximate the law of a stationary R^d-valued Markov and Feller process (X_t). We obtain some general results of convergence of this sequence. Then, we apply them to Brownian diffusions and solutions to Lévy driven SDE's under some Lyapunov-type stability assumptions. As a numerical application of this work, we show that this procedure gives an efficient way of option pricing in stochastic volatility models.
Quantificação da Inativação da Ocratoxina A pela Radiação Gama. Um Exemplo do Potencial da Radiação Ionizante na Descontaminação de Agentes Químicos (2014)

A ocratoxina A (OTA) e uma toxina produzida por fungos em alimentos que podem provocar danos aos homens e animais como, por exemplo, a inducao de câncer. Por isso, e necessario reduzir o conteudo de OTA nos alimentos. A irradiacao e uma tecnica de beneficiamento que consiste na exposicao de produtos a acao de radiacoes ionizantes. A radiacao ionizante tambem pode agir na inativacao de toxinas, degradando-as pela formacao de produtos radioliticos. O presente estudo teve por objetivo verificar a acao de doses de 1, 3 e 5 kGy na inativacao da OTA em solucoes modelo. Para quantificar a reducao do conteudo de toxina nas amostras testadas foram utilizadas tecnicas cromatograficas e os dados obtidos foram submetidos a tratamento estatistico. Foram tambem investigados os possiveis produtos radioliticos caracterizados por espectrometria de massas de alta resolucao com ionizacao por eletrospray. Os resultados revelam que a radiacao ionizante tem potencial para reduzir a toxidez de produtos contaminados com OTA com consideravel inativacao desta toxina a partir da menor dose aplicada (1kGy). Verificou-se que os principais radiolitos sao obtidos pela quebra oxidativa de ligacoes, preferencialmente nas ramificacoes. A identificacao dos principais produtos radioliticos revela que os mesmos sao menos toxicos que os originais. Sendo assim, a aplicacao da radiacao ionizante se apresenta como uma alternativa viavel para a neutralizacao de toxinas, com aplicacao direta na descontaminacao quimica. 10.5935/1984-6835.20140047
Reaction of Platinum(II) N,N‐Dialkyldithiocarbamates with Diphenylphosphane Sulfide (1981)

Novel Anions (1) and new dinuclear complexes (2) are some of the products which have been found during studies on the reactions of Pt(S2CNR2)2 with Ph2P(S)H (R  Et, iPr).
Transmission experiments carried out during the installation of TAT 12 (1996)

The introduction of optical amplifiers to long-haul submarine cable systems has provided the users and system designers with a high-quality bit rate insensitive transmission path, which can be configured in a variety of ways to achieve a required network or traffic interconnection pattern. The initial design of TAT-12 required the transmission of single 5 Gbit/s traffic streams whose error performance would meet the requirements of ITU-T Recommendation G826. In addition the system designers were required to ensure that there was sufficient ageing margin included in the overall design as well as maintain the performance of the network in the presence of other degradation mechanisms that were identified during the development of the system. The results of the transmission experiments are presented.
DEPOSITION CONTROL FOR ELECTROSPUN FIBERS (2016)

Electrospinning (ES) is a process for fabricating polymer fibers that have diameters that range from tens of nanons to hundreds of microns, which has been studied for over 100 years. These fibers have been studied in applications such as: the enhancement of mechanical properties including increased sensor sensitivity and increased tensile strength, filtration enhancement, drug delivery systems, and as a lithography masking material. In order to increase the effectiveness of ES, a real time feedback control mechanism to measure fiber diameters is needed. Currently only post-process methods of measuring fiber morphology, such as scanning electron microscopy or transmission electron microscopy, are used to measure ES fibers. Many parameters including: separation distance, applied voltage, polymer viscosity, polymer molecular weight, and flow rates are used to control fiber morphology. Using these parameters in combination with a feedback control mechanism, a multiple-input multiple-output control mechanism could be developed. By using laser extinction tomography, a device was built to measure fiber diameters during deposition. The laser diagnostic device (LaD) has been able to measure the laser extinction while scanning through fiber depositions with limited repeatability.
Insulin signalling in heart involves insulin receptor substrates-1 and -2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway (1998)

We demonstrate that the early steps of insulin signalling in heart include the phosphorylation-activation of the insulin receptor, engagement of insulin receptor substrates-1 and -2 with the consequent activation of phosphatidylinositol 3-kinase and the involvement of the recently discovered growth related pathway--JAK 2-STAT 1.
Salinity fluctuations and their influence on “bottle brush” morphogenesis inEnteromorpha intestinalis(L.) Link (1978)

The development of proliferous (“bottle brush”) forms of Enteromorpha intestinalis (L.) Link has been studied in relation to salinity changes and also in media of extreme salinity. Two distinct patterns of development may produce similar morphologies; (A) the in situ germination of swarmers and (B) outgrowths from isolated, swollen cells present in the thallus. “Bottle brush” morphogenesis may be initiated by salinity changes and also by prolonged immersion in media of extreme salinity.
Lipoxin A4 Prevents the Progression of De Novo and Established Endometriosis in a Mouse Model by Attenuating Prostaglandin E2 Production and Estrogen Signaling (2014)

Endometriosis, a leading cause of pelvic pain and infertility, is characterized by ectopic growth of endometrial-like tissue and affects approximately 176 million women worldwide. The pathophysiology involves inflammatory and angiogenic mediators as well as estrogen-mediated signaling and novel, improved therapeutics targeting these pathways are necessary. The aim of this study was to investigate mechanisms leading to the establishment and progression of endometriosis as well as the effect of local treatment with Lipoxin A4 (LXA₄), an anti-inflammatory and pro-resolving lipid mediator that we have recently characterized as an estrogen receptor agonist. LXA₄ treatment significantly reduced endometriotic lesion size and downregulated the pro-inflammatory cytokines IL-1β and IL-6, as well as the angiogenic factor VEGF. LXA₄ also inhibited COX-2 expression in both endometriotic lesions and peritoneal fluid cells, resulting in attenuated peritoneal fluid Prostaglandin E₂ (PGE₂) levels. Besides its anti-inflammatory effects, LXA₄ differentially regulated the expression and activity of the matrix remodeling enzyme matrix metalloproteinase (MMP)-9 as well as modulating transforming growth factor (TGF)-β isoform expression within endometriotic lesions and in peritoneal fluid cells. We also report for first time that LXA₄ attenuated aromatase expression, estrogen signaling and estrogen-regulated genes implicated in cellular proliferation in a mouse model of disease. These effects were observed both when LXA₄ was administered prior to disease induction and during established disease. Collectively, our findings highlight potential targets for the treatment of endometriosis and suggest a pleotropic effect of LXA₄ on disease progression, by attenuating pro-inflammatory and angiogenic mediators, matrix remodeling enzymes, estrogen metabolism and signaling, as well as downstream proliferative pathways.
Short Duration Heat Transfer Studies at High Free-Stream Temperatures (1983)

This paper describes short duration heat transfer measurements on a flat plate and a gas turbine nozzle airfoil at high free-stream temperatures. A shock tube generated the high-temperature and pressure air flow. Thin-film heat gages recorded the surface heat flux. The flat plate was tested both in the shock tube and in a shock tunnel placed aft of the tube. Shock tunnel tests on the nozzle airfoil measured the local heat transfer distribution. The flat plate free-stream temperatures varied from 830°R (460 K) to 3190°R (1770 K) for a Tw/TT, g temperature ratio of 0.17 to 0.64 at Mach numbers from 0.12 to 1.34. The nozzle measurements at a Tw/TT, g of 0.35 to 0.39 generally indicate that pressure (concave) surface heat transfer coefficients are high, whereas the suction (convex) surface shows much lower heat transfer coefficients than a turbulent flat-plate correlation.
The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics (2016)

Bill & Melinda Gates Foundation, National Institutes of Health, UK Medical Research Council, UK Department for International Development, Wellcome Trust.
Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development (2012)

Multipotent stem cells and their lineage-restricted progeny drive nephron formation within the developing kidney. Here, we document expression of the adult stem cell marker Lgr5 in the developing kidney and assess the stem/progenitor identity of Lgr5(+ve) cells via in vivo lineage tracing. The appearance and localization of Lgr5(+ve) cells coincided with that of the S-shaped body around embryonic day 14. Lgr5 expression remained restricted to cell clusters within developing nephrons in the cortex until postnatal day 7, when expression was permanently silenced. In vivo lineage tracing identified Lgr5 as a marker of a stem/progenitor population within nascent nephrons dedicated to generating the thick ascending limb of Henle's loop and distal convoluted tubule. The Lgr5 surface marker and experimental models described here will be invaluable for deciphering the contribution of early nephron stem cells to developmental defects and for isolating human nephron progenitors as a prerequisite to evaluating their therapeutic potential.
Transcoding: Extending e-business to new environments (2001)

The promise of e-business is coming true: both businesses and individuals are using the Web to buy products and services. Both want to extend the reach of e-business to new environments. Customers want to check accounts, access information, and make purchases with their cellular phones, pagers, and personal digital assistants (PDAs). Banks, airlines, and retailers are competing to provide the most ubiquitous, convenient service for their customers. Web applications designed to take advantage of the rich rendering capabilities of advanced desktop browsers on large displays do not generally render effectively on the small screens available on phones and PDAs. Some devices have little or no graphics capability, or they require different markup languages, such as Wireless Markup Language (WML), for text presentation. Transcoding is technology for adapting content to match constraints and preferences associated with specific environments. This paper compares and contrasts different approaches to content adapta tion, including authoring different versions to accommodate different environments, using application server technology such as JavaServer pages™ (JSP™) to create multiple versions of dynamic applications, and dynamically transcoding information generated by a single application. For dynamic transcoding, the paper describes several different transcoding methodologies employed by the IBM WebSphere™ Transcoding Publisher product, including HyperText Markup Language (HTML) simplification, Extensible Markup Language stylesheet selection and application, HTML conversion to WML, WML deck fragmentation, and image transcoding. The paper discusses how to decide whether transcoding should be performed at the content source or in a network intermediary. It also describes a means of identifying the device and network characteristics associated with a request and using that information to decide how to transcode the response. Finally, the paper discusses the need for new networking benchmarks to characterize the server load and performance characteristics for dynamic transcoding.
Uptake of Functional Ultrasmall Gold Nanoparticles in 3D Gut Cell Models (Small 31/2022) (2022)

Ultrasmall Gold Nanoparticles Three-dimensional cell culture models represent a bridge between conventional two-dimensional cell culture studies and in-vivo animal experiments. In article number 2201167, Astrid M. Westendorf, Matthias Epple, and co-workers demonstrate the cytostatic action of doxorubicin-carrying ultrasmall gold nanoparticles, including their superior ability to enter the three-dimensional cell cultures compared to dissolved drugs.
Voltage control of variable speed SEIG with Z-Source inverter (2012)

This paper presents a voltage control method for a three-phase Self Excited Induction Generator (SEIG) with Z-Source inverter. A Z-Source inverter with unified control technique is proposed which can boost the voltage and generate the desired output voltage efficiently when the low voltage is available at generator terminals due to low speed operation of generator. And also when the speed of generator is high giving higher voltages the inverter operates as a traditional voltage source inverter to buck the voltage. Thus proposed system is capable of both boosting and bucking voltage. Thus making system suitable for wind turbine distributed Generation system. In unified control technique a unified voltage vector is used which is composed of both traditional voltage vector and unique boost factor which provides fast dynamic response to maintain constant output voltage of inverter in variable speed operation of SEIG.
TouchGrid: Touchpad pointing by recursively mapping taps to smaller display regions (2005)

Touchpad devices are widely used but lacking in pointing efficiency. The TouchGrid, an instance of what we term cell cursors, replaces moving the cursor through dragging the finger on a touchpad with tapping in different regions of the touchpad. The touchpad regions are recursively mapped to smaller display regions and thereby enable high-precision pointing without requiring high tapping precision. In an experiment, six subjects used the TouchGrid and a standard touchpad across different numbers of targets, distances to targets and target widths. Whereas standard touchpad operation follows Fitts' law, target selection time with the TouchGrid is a linear function of the required number of taps. The TouchGrid was significantly faster for small targets and for tasks requiring one tap, and marginally faster for two-tap tasks. Error rates tended to be higher with the TouchGrid than the standard touchpad. All subjects preferred the TouchGrid.