gebhart/patrepeval huggingface dataset:
Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol. (1988)

The mode of attachment of the membrane-bound form of the chromaffin granule glycoprotein dopamine beta-hydroxylase has been investigated; specifically, the possibility of a covalently attached glycosyl phosphatidylinositol anchor has been examined in detail. Incubation of fragmented chromaffin granule membranes with phosphatidylinositol-specific phospholipase C led to no solubilization of dopamine beta-hydroxylase activity. Further, chemical analyses of the inositol and phosphate content of the soluble form of dopamine beta-hydroxylase indicate that the enzyme contains no covalently attached phosphate or inositol. The results of these studies allow elimination of phosphatidylinositol as a source of membrane anchoring for dopamine beta-hydroxylase and, coupled with previously available data, argue against a post-translational covalent modification of the enzyme as the mechanism of membrane attachment. Possible alternative models for the anchoring of membranous dopamine beta-hydroxylase are discussed.
Effect of SO[sub 2] on the Performance of the Cathode of a PEM Fuel Cell at 0.5–0.7 V (2009)

The effect of 1 ppm in air on the performance of the proton exchange membrane (PEM) fuel cell cathodes was studied at operating voltages of 0.5, 0.6, and 0.7 V at and 100% relative humidity. The coverage of the cathode catalyst (50% Pt/Vulcan carbon) with sulfur species after exposure to in air at different cell voltages is evaluated from the hydrogen desorption region on cyclic voltammetry (CV) curves and from ohmic-resistance-corrected polarization curves. The calculated from CVs after exposure to in air is compared to those of cathodes exposed to in nitrogen. The decreases as the cathode potential increases in both air and nitrogen. The cathodes poisoned in air have 2.5 times lower sulfur coverage than those poisoned in nitrogen. The cells poisoned at 0.6 V have the highest performance vs those poisoned at 0.5 and 0.7 V at constant current density; even though the sulfur coverage is lowest in the cell poisoned at 0.7 V, adsorbed hydroxy groups and sulfate/bisulfate ions on the platinum surface are likely to impede the oxygen reduction reaction at 0.7 V. The sulfate/bisulfate ions can be removed from the surface by holding the cathode at its open-circuit voltage in nitrogen.
ChemInform Abstract: Catalytic α‐Monoallylation of Aryl Acetonitriles. (2015)

Abstract The method utilizes an aldehyde to activate nitriles toward α‐allylation and prevent multiple allylations.
MEMS (2005)

Introduction Mohamed Gad-el-Hak Materials for Microelectromechanical Systems Christian A. Zorman, Mehran Mehregany, and J. Jay McMahon MEMS Fabrication Guangyao Jia and Marc J. Madou LIGA and Micromolding Guangyao Jia and Marc J. Madou X-Ray Based Fabrication Todd Christenson EFAB(R) Technology and Applications Adam L. Cohen and Chris A. Bang Single-Crystal Silicon Carbide MEMS: Fabrication, Characterization, and Reliability Robert S. Okojie Deep Reactive Ion Etching for Bulk Micromachining of Silicon Carbide Glenn M. Beheim and Laura J. Evans Polymer Microsystems: Materials and Fabrication Gary M. Atkinson and Zoubeida Ounaies Optical Diagnostics to Investigate the Entrance Length in Microchannels Sang-Youp Lee, Jaesung Jang, and Steven T. Wereley Microfabricated Chemical Sensors for Aerospace Applications Gary W. Hunter, Jennifer C. Xu, Chung-Chiun Liu, and Darby B. Makel Packaging of Harsh Environment MEMS Devices Liang-Yu Chen and Jih-Fen Lei Fabrication Technologies for Nanoelectromechanical Systems Gary H. Bernstein, Holly V. Goodson, and Gregory L. Snider Molecular Self-Assembly: Fundamental Concepts and Applications Jill A. Miwa and Federico Rosei Index
POPULATION GENETICS HISTORY: A PERSONAL VIEW (1987)

We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ...Read More
En Face Optical Coherence Tomography Investigation of Interface Fiber Posts/Adhesive Cement/Root Canal Wall (2009)

This study analyzes the adaptation and gap width between fiber posts, adhesive luting cement and root canal wall using optical coherence tomography. The results prove the importance of assessing the quality of the interface after each process of fiber post luting.
Vitaminstoffwechsel bei Patienten mit Mainz-Pouch-I (1997)

Zur Konstruktion des Mainz-Pouch-I werden zwischen 24 und 36 cm des terminalen Ileums sowie ca. 12 cm Colon ascendens inkl. der Ileozökalklappe verwendet. Hierdurch entfällt ein Teil der Resorptionsfläche für Vitamine, Gallensäuren und Spurenlemente. Bei 137 Patienten mit einem Mainz-Pouch-I erfolgte die Bestimmung der Gallensäuren, der fett- und wasserlöslichen Vitamine (A, D, E, K, B1, B2, B6, B12), der Folsäure, des Ammoniaks und des Base excess, der Spurenelemente (Zink, Kupfer, Eisen), des Ferritins sowie eines Differentialblutbildes. Das Vitamin B12 und die Folsäure wurde zusätzlich intrakorpuskulär bestimmt. Kinder und Erwachsene wurden unterschieden und die Patienten in 3 Gruppen eingeteilt (0-&lt;2; ≥2-&lt;4 und ≥4 Jahre postoperativ). Die Vitamine: A, D, E, K, B1, B2, B6, die Folsäure, die Gallensäuren, das Ammoniak, der Base excess, die Spurenelemente, das Ferritin sowie das Differentialblutbild befanden sich bei allen Patienten im Referenzbereich. Bei den Kindern (n = 51) war keine signifikante Veränderungendes Vitamin-B12 sowohlim Serumalsauch intrakorpuskulär (n = 20) zu beobachten. Die mittlere Vitamin-B12-Konzentration im Serum (Normwert: 240-1100 ng/l) sank bei den Erwachsenen (n = 86) nach dem 4. postoperativen Jahr signifikant in den unteren Normbereich (von 402 ng/l ± 182 auf 292 ng/l ± 204). Die intrakorpuskuläre Vitamin-B12-Konzentration zeigte bei 64 erwachsenen Patienten keine signifikanten Veränderungen zwischen den Gruppen. Bei keinem Patienten konnte eine neurologische Symptomatik oder eine megaloblastäre Anämie beobachtet werden. Bei Patienten mit Mainz-Pouch-I sollte nach dem vierten postoperativen Jahr die Bestimmung des Vitamin B12 erfolgen. Ob eine generelle Substitution im Langzeitverlauf sinnvoll erscheint, muß derzeit noch offen bleiben. Andererseits ist die intramuskuläre Gabe einfacher und kostengünstiger als die regelmäßige Bestimmung.
ETUDE EN SIMPLE AVEUGLE DE LA TRIMEBUTINE ET DE LA MEBEVERINE DANS LE COLON IRRITABLE ET LA DYSPEPSIE (1981)

SCOPUS: NotDefined.j
Unified Visual Relationship Detection with Vision and Language Models (2023)

This work focuses on training a single visual relationship detector predicting over the union of label spaces from multiple datasets. Merging labels spanning different datasets could be challenging due to inconsistent taxonomies. The issue is exacerbated in visual relationship detection when second-order visual semantics are introduced between pairs of objects. To address this challenge, we propose UniVRD, a novel bottom-up method for Unified Visual Relationship Detection by leveraging vision and language models (VLMs). VLMs provide well-aligned image and text embeddings, where similar relationships are optimized to be close to each other for semantic unification. Our bottom-up design enables the model to enjoy the benefit of training with both object detection and visual relationship datasets. Empirical results on both human-object interaction detection and scene-graph generation demonstrate the competitive performance of our model. UniVRD achieves 38.07 mAP on HICO-DET, outperforming the current best bottom-up HOI detector by 14.26 mAP. More importantly, we show that our unified detector performs as well as dataset-specific models in mAP, and achieves further improvements when we scale up the model. Our code will be made publicly available on GitHub.
Generalized Matching Theory for Perfect Transmission of Obliquely Incident Elastic Waves (2022)

We present a novel theory (generalized matching theory) to realize the perfect transmission of obliquely incident elastic waves across dissimilar media. Obliquely incident elastic waves inevitably generate both longitudinal and transverse waves at dissimilar solid-solid interfaces. Due to this intrinsic multimodality, the conventional impedance matching theory fails to achieve the perfect transmission of obliquely incident elastic waves. Here, we show that the perfect transmission across dissimilar media is possible if an anisotropic layer satisfying specific conditions is inserted between them. It is demonstrated that wave transmission from metal (aluminum) to plastic (Polyether ether ketone) plates can be enhanced from 20%-40% to nearly 100% with nearly zero reflection. Experimentally measured amplitudes of the transmitted longitudinal and transverse waves were found to be amplified by 2.59 and 4.55 times, respectively, when the anisotropic layer was inserted.
Media for Microbial Fermentations (2001)

This chapter contains sections titled: Introduction Nutritional Groups Nutritional Requirements Environmental Requirements Medium Formulation Medium Optimization Economics References
Research on the design of multi-redundancy BLDC motor (2012)

In order to improve the reliability of the system, the redundancy technology is introduced into the design of permanent magnetic brushless DC motor. Two kinds of stator structures are designed, including same slot and different slot. The mathematical model of the motor are set up, the winding inductance are analyzed and calculated, and the relationship between the winding inductance and mutual inductance are deduced. According to the mathematical model, the parameters of the motor are designed, and the rotational speed and torque are simulated. The motor are tested based on the magtrol testing system, compared the mechanical characteristic curve of the two kinds under different working modes. The experiment results show that: the motor of two kinds can achieve good dynamic characteristics, and the torque is twice with two sets of windings. Two sets of windings did not affect motor performance, but it greatly improved the system reliability.
Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells (2015)

The novel, chemically stabilized disorazole analog, (-)-CP2-disorazole C1 (1) displayed potent anti-proliferative activity against a broad-spectrum of human colorectal cancer cells. HCT15 and H630R1 cell lines expressing high basal levels of the ABCB1 protein, known to cause multi-drug resistance, were also sensitive to growth inhibition by 1 but were resistant to both vincristine and docetaxel, two commonly used microtubule inhibitors. Compound 1 exhibited strong inhibition of tubulin polymerization at a level comparable to vincristine. In addition, treatment with 1 resulted in decreased protein levels of β-tubulin but not α-tubulin. An analysis of cellular proteins known to interact with microtubules showed that 1 caused decreased expression of c-Myc, APC, Rb, and additional key cellular signaling pathways in CRC cells. Treatment with compound 1 also resulted in G2/M cell cycle arrest and induction of apoptosis, but not senescence. Furthermore, endothelial spheroid sprouting assays demonstrated that 1 suppressed angiogenesis and can, therefore, potentially prevent cancer cells from spreading and metastasizing. Taken together, these findings suggest that the microtubule disruptor 1 may be a potential drug candidate for the treatment of mCRC.
Towards real-time under-ice acoustic navigation at mesoscale ranges (2015)

This paper describes an acoustic navigation system that provides mesoscale coverage (hundreds of kilometers) under the ice and presents results from the first multi-month deployment in the Arctic. The hardware consists of ice-tethered acoustic navigation beacons transmitting at 900 Hz that broadcast their latitude and longitude plus several bytes of optional control data. The real-time under-ice navigation algorithm, based on a Kalman filter, uses time-of-flight measurements from these sources to simultaneously estimate vehicle position and depth-averaged local currents. The algorithm described herein was implemented on Seagliders, a type of autonomous underwater glider (AUG), but the underlying theory is applicable to other autonomous underwater vehicles (AUVs). As part of an extensive field campaign from March to September 2014, eleven acoustic sources and four Seagliders were deployed to monitor the seasonal melt of the marginal ice zone (MIZ) in the Beaufort and northern Chukchi Seas. Beacon-to-beacon performance was excellent due to a sound duct at 100 m depth where the transmitters were positioned; the travel-time error at 200 km has a standard deviation of 40 m when sound-speed is known, and ranges in excess of 400 km were obtained. Results with the Seagliders, which were not regularly within the duct, showed reliable acoustic ranges up to 100 km and more sparse but repeatable range measurements to over 400 km. Navigation results are reported for the real-time algorithm run in post-processing mode, using data from a 295-hour segment with significant time spent under ice.
Sn-Carbon Core-Shell Powder for Anode in Lithium Secondary Batteries (2005)

Spherical Sn-carbon core-shell powder was synthesized through a resorcinol-formaldehyde (RF) microemulsion polymerization&#13;\nperformed in the presence of hydrophobized Sn nanoparticles. The Sn-carbon core-shell structure was found to greatly enhance the&#13;\ncycle life compared to the mixture of Sn and spherical carbon when evaluated as the anode in lithium-ion batteries. A core-shell&#13;\npowder containing 20 wt % Sn showed 69% capacity retention at the 40th cycle when cycled between 0 and 2.0 V (vs Li/Li+) at&#13;\na constant current of 40 mA g−1. The mixture of 20 wt % Sn nanopowder and 80 wt % spherical carbon powder exhibited only&#13;\n10% capacity retention in the same test condition. It is believed that the improved cyclability achieved with the core-shell powder&#13;\nis largely attributed to the inhibition of aggregation between Sn nanoparticles. The marginal polarization due to an intimate&#13;\nelectrical contact made between Sn core and carbon shell is an additional advantageous feature achieved with this electrode.&#13;\n© 2005 The Electrochemical Society.
Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection. (1996)

Human C-type natriuretic peptide 22 (hCNP22), the third member of the natriuretic peptide family, was efficiently synthesized by Fmoc-based peptide chain construction on a 2-chlorotrityl (Clt) resin, followed by deprotection using tetrafluoroboric acid (HBF4). The use of Clt resin was effective in suppressing racemization at the C-terminal cysteine residue caused by the base treatment for Fmoc-cleavage. The disulfide bond of hCNP22 was constructed using the silyl chloride-sulfoxide method to avoid oxidation at the Met residue. Using amino acid- and dipeptide-resin derivatives, the effects of bases, protecting groups and resin supports on the racemization at the C-terminal Cys residue were examined in detail.
Circuit modeling methodology for UWB omnidirectional small antennas (2006)

In ultra-wideband (UWB) systems, antennas act as filters that introduce a frequency dependent response from the transmitter to receiver. To capture the waveform dispersion so that one can equalize/compensate at the transmitter/receiver, a new circuit modeling methodology that handles omnidirectional small antennas is proposed. By transforming the antennas into the degenerated Foster canonical forms and utilizing the waveform-omnidirectional property, it is shown that the transmitted far field waveform is a scaled version of the voltage across the radiation resistor in the model. Extended Thevenin/Norton equivalent circuits with dependent sources tracking the frequency dependence of the antenna effective length are also built for UWB receiving antennas. Simulation and experimental results show that this methodology is effective over a wide bandwidth and suitable for modeling most UWB antennas.
Remote Sensing for Agriculture, Ecosystems and Hydrology III (1999)

The science need for remotely sensed soil moisture has been well established in the hydrologic, climate change and weather forecasting communities. In spite of this well documented science need there are currently no satellite missions flying or funded to make this very important geophysical measurement. There have been a number of experimental aircraft programs that have demonstrated the feasibility of using long wave microwave sensors for estimating soil moisture. Unfortunately, this science driver, soil moisture, imposes very difficult technical requirements for a satellite sensor system. Global soil moisture is driven by a spatial resolution on the order of 20 to 30 km and measurements need to be taken every two to three days to be useful to the science community. The principal sensor to accomplish the soil moisture measurements is an L- band passive microwave radiometer and achieving the spatial and temporal requirements requires a very large antenna. This paper describes the several alternatives to solve the very large antenna challenge and still meet the radiometer sensitivity requirement. The paper also discusses the alternatives considered to obtain the necessary ancillary data for characterizing the surface roughness, the surface temperature and the attenuation affects of vegetation needed to derive the geophysical parameter. Finally, the paper discusses proposed missions and how well they will meet the science requirements.
White‐Light Emission from an Assembly Comprising Luminescent Iridium and Europium Complexes (2004)

Rot, weiß und blau: Weißes Licht resultierte aus dem partiellen Energietransfer (∂ET) zwischen einem blau emittierenden IrIII-Phenylpyridin-Komplex und einem rot emittierenden EuIII-Terpyridin-Chelat, wenn das aus den beiden Metallkomplexen gebildete Assoziat angeregt wurde (siehe Bild). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z461953_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. (1994)

Intraperitoneal injection of pristane (2,6,10,14 tetramethylpentadecane) is a standard technique for obtaining monoclonal antibody-enriched ascitic fluid. However, pristane also induces plasmacytomas and an erosive arthritis resembling rheumatoid arthritis in BALB/c mice, probably as a consequence of enhanced interleukin 6 production. We report here that the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) is a further consequence of injecting pristane in BALB/c mice. Anti-Su antibodies appeared as early as 1-2 mo after a single injection of 0.5 ml pristane, followed by anti-U1RNP and anti-Sm antibodies after 2-4 mo. Within 6 mo of pristane injection, 9 of 11 BALB/c mice had developed anti-Su, anti-U1RNP, anti-U2RNP, anti-Sm, and possibly anti-U5RNP antibodies. Autoantibodies were not produced by 20 BALB/c mice of the same age and sex that were not injected with pristane. Thus, autoantibodies characteristic of lupus were induced in mice that are not usually considered to be genetically susceptible to the disease. The induction of autoantibodies associated with SLE by pristane may be relevant to understanding the role of abnormal cytokine production in autoantibody production and the pathogenesis of autoimmune disease. Furthermore, the induction of high titer autoantibodies by pristane dictates caution in the use of ascitic fluid as a source of monoclonal antibodies, since the polyclonal antibodies induced by pristane may copurify with the monoclonal antibody secreted by an injected hybridoma.
A genetic algorithm for resource-constrained scheduling (1996)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.
The assembly of β‐barrel membrane proteins by BAM and SAM (2020)

Gram-negative bacteria, mitochondria, and chloroplasts all possess an outer membrane populated with a host of β-barrel outer-membrane proteins (βOMPs). These βOMPs play crucial roles in maintaining viability of their hosts, and therefore, it is essential to understand the biogenesis of this class of membrane proteins. In recent years, significant structural and functional advancements have been made toward elucidating this process, which is mediated by the β-barrel assembly machinery (BAM) in Gram-negative bacteria, and by the sorting and assembly machinery (SAM) in mitochondria. Structures of both BAM and SAM have now been reported, allowing a comparison and dissection of the two machineries, with other studies reporting on functional aspects of each. Together, these new insights provide compelling support for the proposed budding mechanism, where each nascent βOMP forms a hybrid-barrel intermediate with BAM/SAM in route to its biogenesis into the membrane. Here, we will review these recent studies and highlight their contributions toward understanding βOMP biogenesis in Gram-negative bacteria and in mitochondria. We will also weigh the evidence supporting each of the two leading mechanistic models for how BAM/SAM function, and offer an outlook on future studies within the field.
ChemInform Abstract: A New Nontricyclic Antidepressant Agent. Synthesis and Activity of N‐[trans‐2‐(Dimethylamino)cyclopentyl]‐N‐(3,4‐dichlorophenyl)propanamide and Related Compounds. (1982)

Abstract Auf den im Formelschema beschriebenen Wegen werden die Cyclopentyl‐ amine (IV), (VIII) und (XI) synthetisiert.
Optimum test patterns for parity networks (1970)

The logic related to the error detecting and/or correcting circuitry of digital computers often contains portions which calculate the parity of a collection of bits. A tree structure composed of Exclusive-OR gates is used to perform this calculation. Similar to any other circuitry, the operation of this parity tree is subject to malfunctions. A procedure for testing malfunctions in a parity tree is presented in this report.
Isolation of Living Conjugated Polymer Chains (2020)

Living polymerizations currently play a central role in polymer chemistry. However, one feature of these polymerizations is often overlooked, namely, the isolation of living polymer chains. Herein we report the isolation of living π-conjugated polymer chains, synthesized by catalyst-transfer polycondensation. Successful preservation of the nickel complex at polymer chain ends is evidenced by nuclear magnetic resonance spectroscopy, end group analysis, and chain extension experiments. When characterizing living chains by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we discovered a unique photoionization–photodissociation fragmentation process for polymers containing a nickel phosphine end group. Living chains are isolated for several types of conjugated polymers as well as discrete living oligomers. Additionally, we are able to recycle the catalysts from the isolated polymer chains. Catalyst recycling after π-conjugated polymerization has previously been impossible without chain isolation. This strategy not only exhibits general applicability to different monomers but also has far-reaching potential for other catalytic systems.
Readily Accessible Chiral Diene Ligands for Rh-Catalyzed Enantioselective Conjugate Additions of Boronic Acids (2011)

Enabled by the broad scope of the Pd-catalyzed asymmetric alkylation of meso- and d,l-divinylethylene carbonate, several chiral diene ligands were prepared in two steps from commercial materials. Subsequently, these ligands were evaluated in the Rh-catalyzed asymmetric conjugate addition of boronic acids to enones.