gebhart/patrepeval huggingface dataset:
IL-12/GM-CSF Coadministration in an SIV DNA Prime/Protein Boost Protocol Enhances Gag-Specific T Cells But Not Virus-Specific Neutralizing Antibodies in Rhesus Macaques (2003)

Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-mediated immune responses to the first two-thirds of the SIV Gag protein and possibly with enhanced SIVsmE660 antibody neutralization at set point, but not with pre- or early postchallenge SIVsmE660 neutralizing antibody production.
A Complete Automated Chain for Flexible Assembly using Recognition, Planning and Sensor-Based Execution (2016)

This paper presents a fully automated system for automatic assembly of aluminum profile constructions. This high grade of automation of the entire process chain requires novel strategies in recognition, planning and execution. The system includes an assembly sequence planner integrated with a grasp planning tool, a knowledge-based reasoning method, a skill-based code generation, and an error tolerant execution engine. The modular structure of the system allows its adaptation to new products, which can prove especially useful for SMEs producing small lot sizes. The system is robust and stable, as demonstrated with the repeated execution of different geometric assemblies.
Differences in specificities of anti‐C3d sera raised to C3d antigens prepared in different ways (1981)

Anti-C3d sera were raised to different C3d antigens or to the same C3d antigen by different methods. Although identical by immunoprecipitation studies, the various anti-C3d sera showed differences in specificities against bound C3d antigen. Such differences were observed wih red blood cells coated with C3d in vivo and in vitro. Antisera made to the C3d-KAF antigen detected fewer molecules/cell on C3d-tryp cells than did antisera made to the C3d-tryp antigen. The converse was true for C3d-KAF cells. "Saturation" experiments indicated that different anti-C3d detected different "subpopulations" of bound C3d. C3d bound to red blood cells in vivo was, in at least one case, detectable by some anti-C3d sera but not by others. Such differences in anti-C3d specificity may be important in determining the optimal characteristics of anti-C3d antiglobulin serum for routine laboratory use.
POS-420 PREVALENCE OF FABRY DISEASE IN CHRONIC KIDNEY DISEASE PATIENTS INCLUDING PATIENTS ON DIALYSIS IN KOREA (2021)

Fabry disease is an X-linked lysosomal storage disorder caused by the deficient activity of α-galactosidase A (α-Gal A), affecting multiple organs including kidney. In this study, we aimed to determine the prevalence of Fabry disease in Korean patients with chronic kidney disease (CKD), involving patients on renal replacement therapy.
Opposite Orientations of a Transcription Factor Heterodimer Bind DNA Cooperatively with Interaction Partners but Have Different Effects on Interferon-β Gene Transcription (2012)

ATF2-Jun, IRF3, and HMGI recognize a composite regulatory element within the interferon-β enhancer (IFNb). Cooperative ATF2-Jun-IRF3 complex formation at IFNb has been proposed to require a fixed orientation of ATF2-Jun binding. Our results show that ATF2-Jun heterodimers bound IFNb in both orientations alone and in association with IRF3 and HMGI. Two sets of symmetrically located amino acid residues in ATF2 and Jun facilitated the interactions between heterodimers bound in opposite orientations and IRF3 at IFNb. IRF3 and HMGI bound IFNb in association with both orientations of ATF2-Jun heterodimers with the same cooperativity. ATF2-Jun heterodimers that bound IFNb in opposite orientations in vitro had different effects on interferon-β gene transcription when they were co-expressed with IRF3 in cultured cells. These heterodimers had different transcriptional activities at different endogenous genes. Different regions of ATF2 and Jun mediated their orientation-dependent transcriptional activities at different genes. These studies revealed that cooperative DNA binding does not require a unique nucleoprotein complex configuration, and that transcription factor complexes that bind the same enhancer in different configurations can have different transcriptional activities.
Disruption of the growth hormone—Signal transducer and activator of transcription 5—Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis† (2009)

Our data suggest that loss of STAT5 sensitizes hepatocytes to bile acid-induced damage and apoptosis caused by disruption of GH-induced transcription of Igf-1 and down-regulation of hepatoprotective genes. These findings could contribute to the understanding of liver fibrosis and future treatment strategies for liver fibrosis.
A Quantitative Systematic Review of Normal Values for Short-Term Heart Rate Variability in Healthy Adults (2010)

Heart rate variability (HRV) is a known risk factor for mortality in both healthy and patient populations. There are currently no normative data for short-term measures of HRV. A thorough review of short-term HRV data published since 1996 was therefore performed. Data from studies published after the 1996 Task Force report (i.e., between January 1997 and September 2008) and reporting short-term measures of HRV obtained in normally healthy individuals were collated and factors underlying discrepant values were identified. Forty-four studies met the pre-set inclusion criteria involving 21,438 participants. Values for short-term HRV measures from the literature were lower than Task Force norms. A degree of homogeneity for common measures of HRV in healthy adults was shown across studies. A number of studies demonstrate large interindividual variations (up to 260,000%), particularly for spectral measures. A number of methodological discrepancies underlined disparate values. These include a systematic failure within the literature (a) to recognize the importance of RR data recognition/editing procedures and (b) to question disparate HRV values observed in normally healthy individuals. A need for large-scale population studies and a review of the Task Force recommendations for short-term HRV that covers the full-age spectrum were identified. Data presented should be used to quantify reference ranges for short-term measures of HRV in healthy adult populations but should be undertaken with reference to methodological factors underlying disparate values. Recommendations for the measurement of HRV require updating to include current technologies.
[Physical activity and training at high altitude]. (2003)

In recent years there has been a growing interest in the effects of high altitudes on the human body. High altitudes are being frequented by more and more people for sport and leisure pursuits, and are increasingly being used both as a training environment and for investigating the healthy body in hypoxic conditions. During the ascent from sea level, atmospheric pressure and partial oxygen pressure decrease, humidity and temperature decrease, and radiation is elevated. The altitudes at which physiological changes and clinical symptoms occur are not constant, but variations may usually appear above 2300-2800 meters. There is a wide variability of reactions to low oxygen in the air inhaled. The physiological parameters during both rest and physical activity at high altitudes are different from those at sea level, and the differences are reflected in concomitant changes in attitude and behavior. Research into altitude as a training environment that could improve athletic endurance and performance has grown in the last decade, with the development of a number of new training methods, such as "Living High--Training Low" and "Training High--Living Low". These have contributed to an improvement of performance in a significant number of athletes. This article will demonstrate the impact and possible dangers of physical activity at high altitude, and will present the current knowledge and methods of altitude training. This article reviews the influence of low air and oxygen pressure on athletic performance. Recommendations are presented regarding physical activity at high altitude and nutritional support.
Malperfusion Syndrome in Type B Aortic Dissection: Role of the Endovascular Procedures (2008)

Key Words: Type B aortic dissectionmalperfusion syndromedescending thoracic aortaendovascular stent-graft repair
Dancing With Wolves: Today's Lone Wolf Terrorists (2012)

Terrorism takes many forms. However, the rise of the self-radicalized lone wolf terrorist has created an increasing dilemma in today’s security environment. This type of emerging terrorism is increasingly found among right-wing reactionaries and religiously radicalized jihadists. With increasingly effective security environments, leaderless resistance has emerged as a threat and tactic facilitated by the internet and other modern information outlets. The unabomber, Oklahoma City bomber, Fort Hood and Oslo assailants are examples of this new form of terrorist. Through the development of a sociologically informed typology that categorizes lone wolf terrorism in terms of motivation, extent of radicalization, form and risk-awareness, a more relevant understanding of this form of non-normative behavior is proposed.
Deep-Treat: Learning Optimal Personalized Treatments From Observational Data Using Neural Networks (2018)

We propose a novel approach for constructing effective treatment policies when the observed data is biased and lacks counterfactual information. Learning in settings where the observed data does not contain all possible outcomes for all treatments is difficult since the observed data is typically biased due to existing clinical guidelines. This is an important problem in the medical domain as collecting unbiased data is expensive and so learning from the wealth of existing biased data is a worthwhile task. Our approach separates the problem into two stages: first we reduce the bias by learning a representation map using a novel auto-encoder network---this allows us to control the trade-off between the bias-reduction and the information loss---and then we construct effective treatment policies on the transformed data using a novel feedforward network. Separation of the problem into these two stages creates an algorithm that can be adapted to the problem at hand---the bias-reduction step can be performed as a preprocessing step for other algorithms. We compare our algorithm against state-of-art algorithms on two semi-synthetic datasets and demonstrate that our algorithm achieves a significant improvement in performance.
HGAN (2019)

In this article, we propose a novel method to address the two-dimensional (2D) image-based 3D object retrieval problem. First, we extract a set of virtual views to represent each 3D object. Then, a soft-attention model is utilized to find the weight of each view to select one characteristic view for each 3D object. Second, we propose a novel Holistic Generative Adversarial Network (HGAN) to solve the cross-domain feature representation problem and make the feature space of virtual characteristic view more inclined to the feature space of the real picture. This will effectively mitigate the distribution discrepancies across the 2D image domains and 3D object domains. Finally, we utilize the generative model of the HGAN to obtain the “virtual real image” of each 3D object and make the characteristic view of the 3D object and real picture possess the same feature space for retrieval. To demonstrate the performance of our approach, We established a new dataset that includes pairs of 2D images and 3D objects, where the 3D objects are based on the ModelNet40 dataset. The experimental results demonstrate the superiority of our proposed method over the state-of-the-art methods.
Recent advances of sonodynamic therapy in cancer treatment (2016)

Sonodynamic therapy (SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.
The life path of A.M. Khaletsky (2022)

Many brilliant scientists, professors, whose life and fate were directly connected with the history of the university, worked at the St. Petersburg State Chemical and Pharmaceutical University. Our national pharmacy owes their talent and enthusiasm. Based on unpublished archival records, the article reconstructs the biography, professional, scientific and social activities of Abram Mikhailovich Khaletsky, a wellknown chemist, professor, Doctor of Chemistry, who made a great contribution to the development of Russian science, who for many years worked as the Head of the Department of Pharmaceutical Chemistry of the Leningrad Pharmaceutical Institution. A graduate of the Medical Department of Kazan University, a student of Academy A.E. Favorsky, he took an active part in the reformation of the educational process of the LCPI. It was A.M. Khaletsky who proposed a new form of appraisal of pharmacists at that time the defense of theses, the first of them were performed at the Department of Organic Chemistry. Among the scientific achievements made under the leadership of A.M. Khaletsky: studies of isomeric changes of keto-alcohol, technology for the production of standard galenical preparations, the method of isolation of -sitosterol, improvement of hormone technology and the search for new hormonal drugs, and many others. Actively promoted the integration of scientific developments in the pharmaceutical industry. Research by Professor A. M. Khaletsky undoubtedly enriched the theory and practice of organic and pharmaceutical chemistry, made the contribution to the science of the relationships between biological structure and activity, replenished the range of medicine with new drugs and methods of their analysis. The article provides information about the work of one of the oldest departments of the Leningrad Chemical and Pharmaceutical Institute - pharmaceutical chemistry during the leadership of A.M. Khaletsky (1950-x).
Feasibility study on 3D frequency-domain anisotropic elastic wave modeling using spectral element method with parallel direct linear solvers (2019)

A feasibility study on 3D frequency-domain anisotropic elastic wave modeling is conducted. The spectral element method is applied to discretize the 3D frequency-domain anisotropic elastic wave equation and the linear system is solved by parallel direct solvers, MUMPS andWSMP. A hybrid implementation of MPI and OpenMP for MUMPS is shown to be more efficient in flops and memory cost during the factorization. The influence of complex topography on MUMPS performance is negligible. With available resources, the largest scale modeling, 30 wavelengths in each dimension, is achieved. Using the block lowrank feature ofMUMPSleads to computational gains compared with the full-rank version. Limitation of MUMPS scalability for large number of MPI processes prompts us to investigate the performance of an alternative linear solver,WSMP. Preliminary comparison on small scale modelings shows a better scalability of WSMP while being more computational demanding. Presentation Date: Monday, September 16, 2019 Session Start Time: 1:50 PM Presentation Start Time: 3:55 PM Location: 304A Presentation Type: Oral
A Layer Stripping Fast Algorithm for the Two-Dimensional Direct Current Inverse Resistivity Problem (1987)

The inverse problem of reconstructing the resistivity of the earth, varying both laterally and with depth, from direct current measurements is considered. The problem is formulated as a multidimensional inverse scattering problem and solved using a layer stripping algorithm. This algorithm recursively reconstructs the resistivity and electrical potential on horizontal planes of increasing depth by downward continuation. This is the first exact solution to the inverse resistivity problem for resistivity varying laterally as well as with depth. The algorithm is an extension of an algorithm proposed by Levy for resistivity varying in one dimension.
High-mobility transparent conductive thin films of cerium-doped hydrogenated indium oxide (2014)

We have developed 100-nm-thick cerium-doped hydrogenated indium oxide (ICO:H) films with a superior Hall mobility of 130–145 cm2 V−1 s−1. The ICO:H films deposited at 150 °C by dc arc-discharge ion plating were post-annealed at 200 °C. The relationship between the Hall mobility and carrier density of the polycrystalline ICO:H films shows that the carrier transport is limited by an ionized impurity scattering mechanism inside the grains. The surfaces of the ICO:H films were found to be very smooth and clear grain-boundary areas were not observed.
Andrology: Seventeen live births after the use of an erbium-yytrium aluminium garnet laser in the treatment of male factor infertility (1994)

Mechanical partial zonal dissection (PZD) is one of the microinsemination techniques developed to improve the chances of fertilization by in-vitro insemination in subfertile males. We developed a new and safe laser method (erbium laser ablation) for PZD, with the aim of producing a precise opening as well as ablation of some layers of the zona pellucida. From February 1992 to March 1993, 104 couples suffering from male factor infertility were treated in our centre. All patients were affected by severe oligoasthenozoospermia and had previously undergone one failed in-vitro fertilization attempt each. Photoablation of the zona pellucida was induced in 512 oocytes by exposure to an erbium--yytrium aluminium garnet (Yag) laser. The openings obtained were approximately 14 microns in diameter. Of the laser-treated oocytes, 158 (30%) fertilized and 139 (88%) cleaved. Nineteen (18.3%) clinical pregnancies resulted and produced 17 newborns, all in good health. In our series there were four miscarriages, 23 damaged oocytes (4.4%) and 13 with three or more pronuclei (2.5%). Considering that the incidence of damaged oocytes and polyspermy is low, it seems that in some cases of male factor infertility erbium-Yag laser photoablation of the oocyte zona pellucida can be considered a procedure which is effective in enhancing fertilization and which is safe, allowing normal embryo development.
In vitro evidence that lipopolysaccharide of an oral pathogen leaks from root‐end filled teeth (2000)

In vitro teeth with gutta-percha root-end fills can permit leakage of LPS from an identified oral pathogen.
Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type (1995)

Large differences in rates within 5-year age groups were found for many histologic types. Retinoblastoma and Wilms' tumor, for instance, had up to eight-fold differences. Substantial differences also were observed for non-Hodgkin's lymphoma, neuroblastoma, Hodgkin's disease, acute lymphoid leukemia, acute myeloid leukemia, and osteosarcoma. In general, rates were higher among males than females, although female rates were often higher among young children. Rates of white children were generally higher than those of black children, especially during the first 5 years of life. Embryonal tumors comprised the majority of neoplasms during the first 2 years of life.
Use of Syringaldazine for Detection of Laccase in Sporophores of Wood Rotting Fungi (1974)

SUMMARYFungal lacease can be detected with the nonautooxidizable laccase-specific compound, syringaldazine, in the presence of tyrosinase and peroxidase. Data are presented from tests with the azine derivative of numerous fungous sporophores and associated decayed woody tissues from various localities in Wisconsin and Oregon. Syringaldazine is shown to be a reliable replacement and more specific reagent for the detection of extracellular fungal laccase, and in the absence of laccase and in the presence of hydrogen peroxide, for peroxidase. Laccase is further implicated in fruit-body formation.
CD7 Expression in Acute Myeloid Leukemia (1995)

The clinical significance of the expression of CD7 antigen on the blasts of 207 consecutive patients with de novo acute myeloid leukemia (AML) was evaluated. For this purpose, fifty-three CD7+ patients (23 females and 30 males; mean age 52 years) were analyzed and classified into the following subtypes according to French-American-British (FAB) classification: 7 M0, 13 M1, 9 M2, 1 M3, 9 M4, 14 M5. Immunophenotypic studies were carried out by flow cytometry and blast cells were selected on the basis of forward light scatter gating and pan-myeloid marker, either CD13 or CD33. All the CD7+ patients were negative for surface CD3 and T-cell-receptor (TCR) molecules. We found no correlation between CD7 expression and sex, age, hepatosplenomegaly and/or central nervous system involvement. The immaturity of CD7+ leukemic cells was supported by the high expression of CD34 (P = 0.001). CD7 positivity was significantly associated with a white blood cell count (WBC) greater than 100 x 10(9)/L (P = 0.003). P-Glycoprotein (P-170) expression was also evaluated in 135 patients by a flow-cytometric assay: there was a close relationship between CD7 and P-170 positivity (P < 0.001). For remission induction, all patients received therapeutic regimens routinely used for AML. The complete remission (CR) rate was significantly lower in CD7+ cases (32% vs 74%, P = 0.001). The overall survival and disease free survival rate of CD7+ AML was lower than those of CD7- patients (P < 0.001 and = 0.002, respectively). CD7+ AML with coexpression of CD14 had a particularly unfavourable response and prognosis in comparison with CD7+ patients without CD14.(ABSTRACT TRUNCATED AT 250 WORDS)
Electrophoretic deposition of carbon nanotubes: recent progress and remaining challenges (2020)

Electrophoretic deposition (EPD) is a powerful technique to assemble carbon nanotube (CNT) coatings and composite films with controlled architectures. This comprehensive review of the EPD of CNTs and CNT-containing composites focuses on achievements within the last 15 years and ongoing challenges. Stable CNT suspensions are a pre-requisite for successful EPD and have been prepared by a variety of strategies, discussed here. The resulting film microstructure is determined by the initial feedstock, the suspension, and the EPD approach applied, as well as a variety of EPD processing parameters. Nanocomposites can be prepared via co-deposition, sequential deposition, or post-deposition treatments, to introduce metallic, ceramic or polymeric phases. There are numerous potential applications for both homogeneous and patterned CNT films, including as structural reinforcements for composites, as field emission, energy storage and conversion devices, as well as in biomedical applications. The advantages and disadvantages of EPD processing in these contexts are discussed.
Physiology and Biochemistry of the Kidney Vacuolar H+-ATPase (1996)

Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane independently from those in intracellular compartments.