gebhart/patrepeval huggingface dataset:
FlowRep (2017)

We present FlowRep , an algorithm for extracting descriptive compact 3D curve networks from meshes of free-form man-made shapes. We infer the desired compact curve network from complex 3D geometries by using a series of insights derived from perception, computer graphics, and design literature. These sources suggest that visually descriptive networks are cycle-descriptive , i.e their cycles unambiguously describe the geometry of the surface patches they surround. They also indicate that such networks are designed to be projectable , or easy to envision when observed from a static general viewpoint; in other words, 2D projections of the network should be strongly indicative of its 3D geometry. Research suggests that both properties are best achieved by using networks dominated by flowlines , surface curves aligned with principal curvature directions across anisotropic regions and strategically extended across sharp-features and isotropic areas. Our algorithm leverages these observation in the construction of a compact descriptive curve network. Starting with a curvature aligned quad dominant mesh we first extract sequences of mesh edges that form long, well-shaped and reliable flowlines by leveraging directional similarity between nearby meaningful flowline directions We then use a compact subset of the extracted flowlines and the model's sharp-feature, or trim, curves to form a sparse, projectable network which describes the underlying surface. We validate our method by demonstrating a range of networks computed from diverse inputs, using them for surface reconstruction, and showing extensive comparisons with prior work and artist generated networks.
Microfluidic Chip to Produce Temperature Jumps for Electrophysiology (2008)

We developed a microfluidic chip that provides rapid temperature changes and accurate temperature control of the perfusing solution to facilitate patch-clamp studies. The device consists of a fluid channel connected to an accessible reservoir for cell culture and patch-clamp measurements. A thin-film platinum heater was placed in the flow channel to generate rapid temperature change, and the temperature was monitored using a thin-film resistor. We constructed the thermal chip using SU-8 on a glass wafer to minimize the heat loss. The chip is capable of increasing the solution temperature from bath temperature (20 degrees C) to 80 degrees C at an optimum heating rate of 0.5 degrees C/ms. To demonstrate the ability of the thermal chip, we have conducted on-chip patch-clamp recordings of temperature-sensitive ion channels (TRPV1) transfected HEK293 cells. The heat-stimulated currents were observed using whole-cell and cell-attached patch configurations. The results demonstrated that the chip can provide rapid temperature jumps at the resolution of single-ion channels.
Cryptocurrencies and Zero Mode Wave guides: An unclouded path to a more contiguous Cannabis sativa L. genome assembly. (2018)

We describe the use of a Decentralized Autonomous Organization (DAO) to crypto-fund the single molecule sequencing and publication of a Type II Cannabis plant. This resulted in the construction of the most contiguous Cannabis genome assembly to date. The combined use of the Dash cryptocurrency, DAOs, and Pacific Biosciences sequencing delivered a 1.03 Gb genome with a N50 of 665Kb in 77 days from funding to public upload. This represents a 230 fold improvement in the contiguity of the first cannabis assemblies in 2011 and a 4 fold improvement over all cannabis assemblies to date. 34Gb of additional sequencing pushed the assembly to a N50 of 3.8Mb. Hi-C data from Phase Genomics further scaffolded the assembly to 35 contigs at an N50 of 74Mb but requires additional curation. The genome is partially phased and larger than previously reported (2N = 1.33Gb). The CBCA, THCA and CBDA synthase gene clusters have been phased onto respective contigs demonstrating tandem repeat expansions.
The relation of retinal sensitivity and rhodopsin in developing rat retina. (1984)

The authors have studied the relations of rhodopsin and retinal sensitivity in developing albino rats, (1) in the dark-adapted state and (2) after exposure to light that bleaches greater than 90% of rhodopsin. Developmental increases in dark-adapted b-wave sensitivity and rhodopsin content were related directly as has been reported previously for rhodopsin and PIII sensitivity of other developing retinas. During dark-adaptation, infant rat log a-wave and log b-wave sensitivities and adults' log b-wave sensitivity were related linearly to the proportion of rhodopsin present. The authors suspect that the sensitivity-rhodopsin relations of infant rat retina are determined mainly by photoreceptor processes. Thus, the infant rat provides a model for investigation of mechanisms underlying both (1) the direct relation of sensitivity and rhodopsin and (2) the log sensitivity-rhodopsin relation.
A Dialogue Agent with Adaptive and Proactive Capabilities (2006)

This paper presents a novel approach to the personalization of natural language dialogue agents. The adaptation to a given user relies on usage modeling at the interaction level. The purpose of this paper is to apply such an approach to adaptation within the dialogue agent (i.e. the interface). The goal is to make the dialogue agent behave proactively. Our approach is characterized by its genericity: it is defined independently from the types of speech acts, from the mode of interaction and from the application behind the dialogue agent. We show how such an approach can be relevant in the case of natural language dialogue and how it contributes to user's acceptance of the related supported services.
Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model (2020)

Feline immunodeficiency virus (FIV) infection like human immunodeficiency virus (HIV), produces systemic and central nervous system disease in its natural host, the domestic cat, that parallels the pathogenesis seen in HIV-infected humans. The ability to culture feline nervous system tissue affords the unique opportunity to directly examine interactions of infectious virus with CNS cells for the development of models and treatments that can then be translated to a natural infectious model. To explore the therapeutic potential of a new p75 neurotrophin receptor ligand, LM11A-31, we evaluated neuronal survival, neuronal damage and calcium homeostasis in cultured feline neurons following inoculation with FIV. FIV resulted in the gradual appearance of dendritic beading, pruning of processes and shrinkage of neuronal perikarya in the neurons. Astrocytes developed a more activated appearance and there was an enhanced accumulation of microglia, particularly at longer times post-inoculation. Addition of 10 nM LM11A-31, to the cultures greatly reduced or eliminated the neuronal pathology as well as the FIV effects on astrocytes and microglia. LM11A-31 also, prevented the development of delayed calcium deregulation in feline neurons exposed to conditioned medium from FIV treated macrophages. The suppression of calcium accumulation prevented the development of foci of calcium accumulation and beading in the dendrites. FIV replication was unaffected by LM11A-31. The strong neuroprotection afforded by LM11A-31 in an infectious in vitro model indicates that LM11A-31 may have excellent potential for the treatment of HIV-associated neurodegeneration.
General requirement for RNA polymerase II holoenzymes in vivo. (1995)

Yeast RNA polymerase II holoenzymes have been described that consist of RNA polymerase II, a subset of general transcription factors, and nine SRB regulatory proteins. The feature that distinguishes the RNA polymerase II holoenzymes from other forms of RNA polymerase II in the cell is their tight association with SRB proteins. We investigated the fraction of genes that require SRB proteins in vivo by examining the effect of temperature-sensitive mutations in SRB genes on transcription by RNA polymerase II. Upon transfer to the restrictive temperature, there is a rapid and general shutdown of mRNA synthesis in srb mutant cells. These data, combined with the observation that essentially all of the SRB protein in cells is tightly associated with RNA polymerase II molecules, argue that SRB-containing holoenzymes are the form of RNA polymerase II recruited to most promoters in the cell.
Association of baseline frailty and age with postoperative outcomes in metastatic brain tumor patients (2022)

The present study, based on analysis of data from a large national registry, shows that frailty, when compared with age, is a superior predictor of postoperative outcomes in metastatic brain tumor patients. A future prospective study, namely a randomized controlled trial, would be beneficial in helping to corroborate the findings of this retrospective study.
Factors Affecting Wound Healing (2010)

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
Semidefinite Representations of Gauge Functions for Structured Low-Rank Matrix Decomposition (2017)

This paper presents generalizations of semidefinite programming formulations of 1-norm optimization problems over infinite dictionaries of vectors of complex exponentials, which were recently proposed for superresolution, gridless compressed sensing, and other applications in signal processing. Results related to the generalized Kalman--Yakubovich--Popov lemma in linear system theory provide simple, constructive proofs of the semidefinite representations of the penalty functions used in these applications. The connection leads to several extensions to gauge functions and atomic norms for sets of vectors parameterized via the nullspace of matrix pencils. The techniques are illustrated with examples of low-rank matrix approximation problems arising in spectral estimation and array processing.
Selected commensal‐related bacteria and Toll‐like receptor 3 agonist combinatorial codes synergistically induce interleukin‐12 production by dendritic cells to trigger a T helper type 1 polarizing programme (2008)

Enteric infections remain a major health problem causing millions of deaths in developing countries. The interplay among the host intestinal epithelium, the mucosa-associated immune system and microbiota performs an essential role in gut homeostasis and protection against infectious diseases. Dendritic cells (DCs) play a key role in orchestrating protective immunity and tolerance in the gut. The mechanisms by which DCs adapt their responses and discriminate between virulent microbes and trillions of innocuous bacteria remain ill-defined. Here we investigated the effect of cross-talk between commensal-related bacteria (CB) and Toll-like receptor (TLR) agonists on DC activation and the outcome of the in vitro T helper response. Human monocyte-derived DCs were exposed to eight different Gram-positive or Gram-negative CB strains prior to activation with five different TLR agonists. The key polarizing cytokines interleukin (IL)-12p70, IL-10, IL-1beta and IL-6 were quantified and the fate of naïve T-cell differentiation was evaluated. We identified a unique combination of Lactobacillus casei and TLR3 signals that acted in synergy to selectively increase IL-12p70 secretion. Exposure to poly(I:C) converted L. casei-treated DCs into potent promoters of T helper type 1 (Th1) responses. We propose that DCs can integrate harmless and dangerous non-self signals delivered by viral products, to mount robust Th1 responses. Thus, in vivo DC targeting with selective probiotics may improve strategies for the management of enteric diseases.
Control of a Robot Dancer for Enhancing Haptic Human-Robot Interaction in Waltz (2012)

Haptic interaction between a human leader and a robot follower in waltz is studied in this paper. An inverted pendulum model is used to approximate the human's body dynamics. With the feedbacks from the force sensor and laser range finders, the robot is able to estimate the human leader's state by using an extended Kalman filter (EKF). To reduce interaction force, two robot controllers, namely, admittance with virtual force controller, and inverted pendulum controller, are proposed and evaluated in experiments. The former controller failed the experiment; reasons for the failure are explained. At the same time, the use of the latter controller is validated by experiment results.
Numerical Simulation of Single- and Dual-media Thermocline Tanks for Energy Storage in Concentrating Solar Power Plants (2014)

A single molten-salt thermocline tank is a low-cost alternative to conventional multiple-tank systems for concentrating solar power thermal energy storage. Thermocline tanks are typically composed of molten salt and a filler material that provides sensible heat capacity at reduced cost; such tanks are referred to as a dual-media thermocline (DMT). However, inclusion of quartzite rock filler introduces the potential for mechanical ratcheting of the tank wall during thermal cycling. To avoid this potential thermomechanical mode of failure, the tank can be operated solely with molten salt, as a single-medium thermocline (SMT) tank. In the absence of a filler material to suppress formation of tank-scale convection eddies, the SMT tank may exhibit undesirable internal fluid flows in the tank cross-section. The performance of DMT and SMT tanks is compared under cyclic operation, assuming adiabatic external wall boundary conditions. A computational fluid dynamics model is used to solve for the spatial temperature and velocity distributions within the tank. For the DMT tank, a two-temperature model is used to account for the non-thermal equilibrium between the molten salt and the filler material, and Forchheimer's extension of Darcy's Law is added to the porous-medium formulation of the laminar momentum equation. The governing equations are solved numerically using a finite volume approach. For adiabatic external boundaries, the SMT tank yields a percentage point increase in the first and second law efficiencies relative to the DMT tank. Future work is needed to compare the thermocline tank designs with respect to capital cost and storage performance under non-adiabatic wall boundaries.
Effect of hydroxyapatite coating crystallinity on dissolution and osseointegration in vivo (2005)

Hydroxyapatite (HA) coating with different crystallinities were deposited by plasma spraying and vapor-flame treatment process. Their crystallinities are about 55 and 98%, respectively. These coatings were implanted in cortical bone, muscle, and marrow of dogs. The dissolution and osseointegration behavior were evaluated by scanning electron microscope (SEM) observation histological analysis. The results obtained indicated that after implanted in muscle, a bone-like apatite layer was formed on the surface of as-sprayed coating, which was not observed on the surface of the treated coating. The as-sprayed coating has the ability to induce new bone formation on its surface after implanted in marrow. In contrast, the treated coating displays a limited bone bioactivity. The vapor-flame process diminishes the short-term osseointegration properties of the HA coating, but no significant affection was found after three months implantation. Either in muscle or in cortical bone, treated coating exhibits higher stability than the as-sprayed coating, in some conditions.
Staphylococcus aureus Colonization and Strain Type at Various Body Sites among Patients with a Closed Abscess and Uninfected Controls at U.S. Emergency Departments (2015)

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a prevalent cause of skin and soft tissue infections (SSTI), but the association between CA-MRSA colonization and infection remains uncertain. We studied the carriage frequency at several body sites and the diversity of S. aureus strains from patients with and without SSTI. Specimens from the nares, throat, rectum, and groin of case subjects with a closed skin abscess (i.e., without drainage) and matched control subjects without a skin infection (n = 147 each) presenting to 10 U.S. emergency departments were cultured using broth enrichment; wound specimens were cultured from abscess cases. Methicillin resistance testing and spa typing were performed for all S. aureus isolates. S. aureus was found in 85/147 (57.8%) of abscesses; 49 isolates were MRSA, and 36 were methicillin-susceptible S. aureus (MSSA). MRSA colonization was more common among cases (59/147; 40.1%) than among controls (27/147; 18.4%) overall (P < 0.001) and at each body site; no differences were observed for MSSA. S. aureus-infected subjects were usually (75/85) colonized with the infecting strain; among MRSA-infected subjects, this was most common in the groin. The CC8 lineage accounted for most of both infecting and colonizing isolates, although more than 16 distinct strains were identified. Nearly all MRSA infections were inferred to be USA300. There was more diversity among colonizing than infecting isolates and among those isolated from controls versus cases. CC8 S. aureus is a common colonizer of persons with and without skin infections. Detection of S. aureus colonization, and especially MRSA, may be enhanced by extranasal site culture.
Molecular Dynamics of QA-• and QB-• in Photosynthetic Bacterial Reaction Centers Studied by Pulsed High-Field EPR at 95 GHz (2002)

The anisotropic transverse relaxation times T2 of the primary and secondary acceptor quinone radical anions QA-• and QB-• in Zn-substituted photosynthetic bacterial reaction centers of Rhodobacter sphaeroides R26 have been studied by means of 2D high-field/high-frequency (3.4 T/95 GHz, W-band) electron spin−echo spectroscopy. The swept magnetic field is the first, and the pulse-separation time is the second variable. Because of the high magnetic field in W-band EPR, the anisotropic Zeeman interactions of quinone radical anions are resolved; therefore, the orientation dependence of the T2 relaxation time can be investigated. For QA-• and QB-•, the monoexponential echo decays at 120 K have different orientation-dependent time constants. The anisotropy of the relaxation times is related to anisotropic stochastic fluctuations of the quinones in their protein-binding pockets, which are temperature-dependent. A model is proposed in which the orientation-dependent relaxation originates in reorientational fluctuations around the quinones' specific hydrogen bonds to surrounding amino acids in the binding sites.
Estimating The Distribution Of 3D Generalized Cylinders Angles From An Image (2013)

Publication in the conference proceedings of EUSIPCO, Marrakech, Morocco, 2013
Games@large graphics streaming architecture (2008)

In coming years we will see low cost networked consumer electronics (CE) devices dominating the living room. Various applications will be offered, including IPTV, VoIP, VoD, PVR and others. With regards to gaming, the need to compete with PlayStation and Xbox will require a radical change in system architecture. While traditional CE equipment suffers from having to meet low BOM (bill of materials) targets, dictated by highly competitive market and cable companies targeted costs, consoles enjoy superior hardware and software capabilities, being able to offset hardware and BOM costs with software royalties. Exent Technologies is leading the European FP6 Integrated Project Games@Large, whose mission is to research, develop and implement a new platform aimed at providing users with a richer variety of entertainment experience in familiar environments, such as their house, hotel room, and Internet Cafe. This will support low-cost, ubiquitous game-play throughout such environments, while taking advantage of existing hardware and providing multiple members of the family and community the ability to play simultaneously and to share experiences. This paper focuses on one of the innovative aspects of the Games@Large project idea - the interactive streaming of graphical output to client devices. This is achieved by capturing the graphical commands at the DirectX API on the server and rendering them locally, resulting in high visual quality and enabling multiple game execution. In order to support also small handheld devices which lack hardware graphics support, an enhanced video method is additionally provided.
Clinical Effects of Cycloxygenase-2 Inhibitor on Nocturia (2009)

Purpose: This study aimed to examine the effects of cyclooxgenase-2 inhibitors on patients with nocturia, whose symptoms persisted after the use of first-line drug therapy, such as alpha blockers and/or anticholinergics.
ChemInform Abstract: Halo(halovinyl)carbenes by α‐Elimination of Oligohalopropenes and Their Intermolecular Trapping: A New Route to (Halovinyl)cyclopropanes. (1987)

Abstract The (halovinyl)cyclopropanes (IV), (VI), (VIII) (+ by‐product (IX)), and (XI) are prepared by α‐dehydrohalogenation of the oligohalopropenes (V), (VII) (E/Z‐mixture), or (X) in the presence of olefins (I), (II), or (III).
Well-defined synthetic polymers with a protein-like gelation behavior in water (2010)

Homopolymers of N-acryloyl glycinamide were prepared by reversible addition-fragmentation chain transfer polymerization in water. The formed macromolecules exhibit strong polymer-polymer interactions in aqueous milieu and therefore form thermoreversible physical hydrogels in pure water, physiological buffer or cell medium.
Resolution of enantiomeric hydrocarbon biomarkers of geochemical importance. [Erratum to document cited in CA116(10):98619v] (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResolution of enantiomeric hydrocarbon biomarkers of geochemical importance. [Erratum to document cited in CA116(10):98619v]Daniel W. Armstrong, Yubing. Tang, and Janusz. ZukowskiCite this: Anal. Chem. 1992, 64, 3, 335Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://doi.org/10.1021/ac00027a019RIGHTS & PERMISSIONSArticle Views30Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (53 KB) Get e-Alertsclose Get e-Alerts