gebhart/patrepeval huggingface dataset:
A novel nanospray capillary zone electrophoresis/mass spectrometry interface (1999)

The high resolution of capillary zone electrophoresis/mass spectrometry (CZE/MS) offers a promising technique to characterize biomolecules in pharmaceutical and biotechnology industries. A novel capillary zone electrophoresis/electrospray ionization time-of-flight mass spectrometry (CZE/ESI-TOFMS) interface was designed in this study to successfully integrate ESI-TOFMS, nanospray, and CZE for biomolecular identification. The interface offers a novel way to take advantage of the high resolution separation achieved during CZE and the detection sensitivity of nanospray ESI-MS. The results showed mixtures of peptides were highly resolved within a few minutes (each CZE electropherogram of a peptide is 2-3 seconds). The novel CZE/ESI-TOFMS interface may simultaneously provide sensitivity, data acquisition speed, mass range, and mass resolution while maintaining resolution of the CZE separation.
The first examples of mRNA cap analogs bearing boranophosphate modification (2008)

The syntheses of mRNA cap analogs modified with boranophosphate moiety at either the alpha or beta-position of the 5', 5'-triphosphate bridge (m(7)Gppp(BH3)G, m(7)Gpp(BH3)pG and m(7)Gpp(BH3)pm(7)G) are described. The preliminary biological characterization of these compounds revealed that they have high affinity for translational factor eIF4E and high potency to inhibit cap-dependent translation in cell free system. The analogs modified at the beta-position were also found to be resistant to DcpS decapping pyrophosphatase.
Remote control and robotics in construction engineering (1991)

This paper presents some topics on remote control and teleoperation in the construction fields. A teleoperated system, able to assembly and manipulate objects, is working in the laboratory of the Department of Mechanics. Politecnico di Milano, with the aim to improve the interface among operator and remote structure. Use of CAD/CAM is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects (2019)

The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (<i>p</i> = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (<i>p</i> = 0.180), non-diabetic versus T2D subjects (<i>p</i> = 0.583), and T1D versus T2D patients (<i>p</i> = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (<i>p</i> < 0.001), tobacco exposure (<i>p</i> = 0.006), T2D (<i>p</i> = 0.020), and a higher-platelets count (<i>p</i> = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D.
Incorporation of Security Mechanisms into the TMO Scheme for Real Time Distributed Computing (2009)

Many real-time distributed computing (RTDC) applications have stringent action timing requirements as well as tight security-enforcement requirements. Integration of security enforcement mechanisms into advanced component-based RTDC schemes has been recognized as an important research topic in recent years. In this paper we propose the first formal extension of the Time-triggered Message-triggered Object (TMO) component model devised to facilitate efficient construction of secure RTDC applications. The newly extended TMO structure is called the Adaptive Secure TMO (AS-TMO). A distinguishing characteristic of the proposed scheme is that security attributes (e.g., roles) are associated with AS-TMO parts (e.g., methods and data-container variable groups) instead of with entire AS-TMOs. We also present the execution engine facilities being incorporated into the middleware model, the TMO Support Middleware (TMOSM), for providing the security-enforcement capabilities defined in the AS-TMO scheme.
Automated spin-assisted layer-by-layer assembly of nanocomposites (2009)

We present the design and verification of a desktop system for the automated production of nanostructured thin films via spin-assisted layer-by-layer (spin-LBL) assembly. The utility of this system is demonstrated by fabricating polyvinyl alcohol/clay nanocomposites. Ellipsometry measurements demonstrate that the automated spin-LBL method creates composites with bilayer thickness and growth rate comparable to traditional dip-LBL; however, the cycle time of the spin-LBL method is an order of magnitude faster. Small angle X-ray scattering analysis shows that the clay platelets in spin-LBL nanocomposites are more highly aligned than in dip-LBL composites. This method can significantly increase the throughput of laboratory-scale LBL discovery and processing, can enable testing of functional properties of LBL nanocomposites over wafer-scale areas, and can be scaled to larger substrates for commercial production.
Pre-S1 antigens and antibodies early in the course of acute hepatitis B virus infection (1986)

The presence of the two "large" surface proteins of hepatitis B virus (HBV), P39 and GP42 of pre-S1-hepatitis B surface antigen, was assayed in the serum of an experimentally infected chimpanzee by using antibodies to a pre-S1-specific fusion protein synthesized in Escherichia coli. The immune response to pre-S1-hepatitis B surface antigen was monitored by using the pre-S1 fusion protein as an antigen. pre-S1 proteins were detected in the serum early in the course of infection and prevailed as long as hepatitis B surface antigen did, together with hepatitis B e antigen and viral DNA. Thus, the pre-S1 antigen can be considered a novel diagnostic marker for acute HBV infection. Antibodies to pre-S1, both immunoglobulin M and G classes, were also detected early in infection, shortly after the appearance of the pre-S1 antigen, suggesting its strong immunogenicity in vivo. The anti-pre-S1 antibodies therefore also represent an early serological marker for acute HBV infection and, owing to their early appearance and persistence, may play a role in the neutralization of the virus.
External silane donors in Ziegler‐Natta catalysis. Computerbased molecular model calculations on alkoxysilanes (1992)

Abstract The electronic factors of external alkoxysilane donors used in modern Ziegler‐Natta catalyst systems were estimated by quantum mechanical MNDO (modified neglect of diatomic overlap) calculations on model compounds. The calculated electron densities of oxygen atoms in alkoxy groups were plotted against the experimental activity and the isotacticity of propene polymerization. The steric hindrance and the volume of the compounds were investigated as structural factors important to the polymerization. The results indicate that the performance of the external alkoxysilane donor is affected by both electronic and structural factors. The average electron density around the electron‐donating oxygens has some influence on the deactivating power of the donor, but when the hydrocarbon part is sterically large the sterical effects apparently dominate.
Assessing patients with fibromyalgia from a rheumatologist’s perspective: a three-step methodology for differential diagnosis (2009)

Fibromyalgia (FM) is a topical and controversial disorder of intriguing complexity with beguiling therapeutic challenges. Its pathophysiology remains elusive and for many clinicians, assessing patients with FM is disheartening. This review attempts to demystify the FM presentation and outline a pragmatic three-step process to redirect analysis of FM signs and symptoms. Understanding the impact of sleep quality on central sensitization and patient presentation is essential. Furthermore, the impact of autonomic dysregulation on sleep quality and its prominence in the multilayered FM clinical presentation will be discussed. Finally discussed is how initial segregation of sleep and autonomic regulatory concerns yield a practical, integrative framework for ultimately analyzing other comorbidities.
A framework and method for hierarchical test generation (1992)

The authors present an algorithm for hierarchical test generation based on module-oriented decision making (MODEM). The algorithm deals with combinational logic modules and the traditional single-stuck-at model. Modules and faults are captured at the function as well as the gate level. The benefits of hierarchy are realized by introducing a generic module representation and the concepts of a dynamic netlist and a dynamic calculus. The authors present the key elements of MODEM: the framework and fault targeting strategy, the module characterization, and a notation and calculus for module-oriented decision making. They conclude with a high-level view of MODEM implementation and experimental results on a variety of hierarchical benchmarks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interactive Localization and Recognition of Objects for the Blind (2006)

We present an improved prototype for the interactive localization and recognition of objects for the blind by matching stereo images, orientation and 3D model information. The foundation of any orientation and navigation system for the blind is an accurate determination of the user’s position and the location of objects within his environment. This is also the reason why most available systems have weaknesses or even fail. In order to address this problem, we previously
Ultra-fast voltage comparators for transient waveform analysis (1990)

The time at which an input signal crosses the reference level of a voltage comparator can be used in the analog-to-digital conversion of fast single waveform transients. In such a converter, an array of identical comparators, properly biased, provides stop inputs to a picosecond-resolution multistop time digitizer. Each stop represents a point in the voltage-time reconstruction of the measured waveform. A number of state-of-the-art comparators, bipolar and GaAs, have been evaluated for this application to determine the differences in their time propagation as a function of the input signal overdrive and risetime. Normalized data are presented to assist in the correction of a digitizer's measurement errors. A picosecond time resolution measurement system used in the tests is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis and design of a high-efficiency multistage Doherty power amplifier for wireless communications (2005)

A comprehensive analysis of a multistage Doherty amplifier, which can be used to achieve higher efficiency at a lower output power level compared to the classical Doherty amplifier, is presented. Generalized design equations that explain the operation of a three-stage Doherty amplifier, which can be easily extended to an N-stage Doherty amplifier, are derived. In addition, the optimum device periphery, which minimizes AM-AM distortion for perfect Doherty amplifier operation, is analyzed. For the first time, a multistage Doherty power amplifier that meets wide-band code-division multiple-access (WCDMA) requirements is demonstrated. The designed power amplifier exhibits a power-added efficiency (PAE) of 42% at 6-dB output power backoff and 27% at 12-dB output power backoff. These PAEs are more than 2/spl times/ and 7/spl times/ better, respectively, than that of a single-stage linear power amplifier at the same output power backoff levels. The power amplifier is capable of delivering up to 33 dBm of output power, and has a maximum adjacent channel power leakage ratio of -35 and -47 dBc at 5- and 10-MHz offset, respectively. To the best of the authors' knowledge, these represent the best reported results of a Doherty amplifier for WCDMA application in the 1.95-GHz band to date.
MoS2/TiO2 heterostructures as nonmetal plasmonic photocatalysts for highly efficient hydrogen evolution (2017)

Periodically patterned MoS<sub>2</sub>/TiO<sub>2</sub> heterostructures were rationally designed as nonmetal plasmonic photocatalysts for highly efficient hydrogen evolution.
Robustness Meets Algorithms (Invited Talk) (2018)

In every corner of machine learning and statistics, there is a need for estimators that work not just in an idealized model but even when their assumptions are violated. Unfortunately in high-dimensions, being provably robust and efficiently computable are often at odds with each other. In this talk, we give the first efficient algorithm for estimating the parameters of a high-dimensional Gaussian which is able to tolerate a constant fraction of corruptions that is independent of the dimension. Prior to our work, all known estimators either needed time exponential in the dimension to compute, or could tolerate only an inverse polynomial fraction of corruptions. Not only does our algorithm bridge the gap between robustness and algorithms, it turns out to be highly practical in a variety of settings.
Correlation between Soil pH, Heterodera glycines Population Densities, and Soybean Yield (2010)

Soybean cyst nematode ( Heterodera glycines Ichinohe) is the most damaging pathogen of soybean [ Glycine max (L.) Merr.] in the United States. Observations in fields suggest that high H. glycines population densities are associated with high soil pH, but H. glycines and soil pH have not been linked to soybean yield. The objective of our study was to assess the relationship between soil pH and H. glycines population densities and subsequent effect on yield. Experiments were conducted in Wisconsin from 1997 to 2000 and in Iowa from 1996 to 1998. Results were consistent among the experiments and showed a positive correlation between soil pH and H. glycines population densities and a negative correlation between yield and both soil pH and H. glycines population densities in both states. In the Wisconsin experiment, yield of both H. glycines –resistant and H. glycines –susceptible cultivars decreased as pH increased, but the decrease was less with H. glycines –resistant cultivars. Overall, results indicate that H. glycines population densities and the impact of nematode population densities on soybean yield are related to soil pH; however, the mechanism of these interactions is unknown.
Symerton--using virtualization to accelerate packet processing (2006)

The complexity of packet-processing applications continues to grow, with encryption, compression, and XML processing becoming common on packet-processing devices at the edge of enterprise and service provider networks. While performance remains a key differentiator for these devices, the complexity and rate of change in the supported applications has made general-purpose platforms an attractive alternative to ASICs and network processors. General-purpose platforms offer excellent programmability and a wealth of existing software, in the form of operating systems, libraries, and applications that can be used to build a packet-processing system; however, the performance of general-purpose operating systems is unacceptable for many environments. This has driven developers to either make derivative versions of existing operating systems or to use special-purpose operating systems with a less comprehensive and familiar library of existing software.As part of the Symerton project, we propose using virtualization to address these issues. We have designed a system that has a virtual machine dedicated to high-performance networking, and a virtual machine dedicated to hosting non-performance critical tasks in a general-purpose operating system. Using a proof-of-concept implementation, we show that the resulting system outperforms a general-purpose operating system by an average of 22% for a real networking application. We also discuss tradeoffs that will need to be considered in further development of systems using this design.
Catalytic Free Radical Rearrangement of Alkylbenzenes (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Free Radical Rearrangement of AlkylbenzenesLynn H. Slaugh and John H. RaleyCite this: J. Am. Chem. Soc. 1962, 84, 13, 2640–2644Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/ja00872a035https://doi.org/10.1021/ja00872a035research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Versatile Homoallylic Boronates by Chemo‐, SN2′‐, Diastereo‐ and Enantioselective Catalytic Sequence of Cu−H Addition to Vinyl‐B(pin)/Allylic Substitution (2016)

A highly chemo-, diastereo- and enantioselective catalytic method that efficiently combines a silyl hydride, vinyl-B(pin) (pin=pinacolato) and (E)-1,2-disubstituted allylic phosphates is introduced. Reactions, best promoted by a Cu-based complex with a chiral sulfonate-containing N-heterocyclic carbene, are broadly applicable. Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phosphates may thus be converted to the corresponding homoallylic boronates and then alcohols (after C-B bond oxidation) in 46-91 % yield and in up to >98 % S<sub>N</sub> 2':S<sub>N</sub> 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio. The reasons why an NHC-Cu catalyst is uniquely effective (vs. the corresponding phosphine systems) and the basis for different trends in stereoselectivity are provided with the aid of DFT calculations.
Non-Hodgkin's lymphomas in childhood a clinicopathologic and epidemiologic study in finland (1987)

All cases diagnosed in Finland as non-Hodgkin's lymphoma (NHL), Hodgkin's disease or histiocytosis X in children younger than 15 years in 1953 to 1973, according to the Finnish Cancer Registry, were reexamined histologically. Only 55% of the cases originally diagnosed as NHL were regarded as such at reexamination. The others were mainly malignant nonlymphatic tumors such as neuroblastoma and different kinds of sarcomas. Seventy-two NHLs were diagnosed in 50 boys and 22 girls. The corrected age-specific incidence rate was 0.32/10(5). The most common histologic types were Burkitt's lymphoma (BL) (30 cases), lymphoblastic lymphoma (LBL) (26), large cell lymphomas (LCL) (six), and non-Burkitt's lymphoma (n-BL) (three). There were marked differences between BL and LBL in the course of the disease: BL was extranodal in 83%, LBL only in 4% (mediastinum was regarded as nodal); BL showed initial abdominal or pelvic involvement in 60% whereas LBL showed none; BL had initial mediastinal involvement in 7%, and LBL had it in 62%; all patients with LBL died whereas 23% of those with BL survived. Other types of NHL resembled BL in their course of disease. Patients with initial tonsillary involvement appeared to have the best prognosis and patients with mediastinal involvement the poorest. The importance of accurate histologic classification is emphasized. It appears to be most important to differentiate LBL from other types of NHL.
Interaction of urokinase with specific receptors abolishes the time of commitment to terminal differentiation of murine erythroleukaemia (Friend) cells (1987)

We have shown the presence of specific receptors for human urokinase on the surface of mouse erythroleukaemic cells. The receptor number increases when undifferentiated cells undergo hexamethylene-bisacetamide induced differentiation, while affinity between receptor and ligand does not change. A monoclonal antibody against the 17,500 mol wt fragment of the non-catalytic chain of urokinase (A chain) inhibits the specific binding, as we have previously shown in A431 cells. We have found that, upon the simultaneous addition of both urokinase or the A chain and hexamethylenebisacetamide, commitment is initiated immediately without the lag shown by control cultures of undifferentiated cells treated with the low molecular weight inducer alone. A series of mechanisms possibly involved in the action of urokinase on mouse erythroleukaemic differentiation are also discussed.
Determination of edge purity in bilayer graphene using μ-Raman spectroscopy (2010)

Polarization resolved μ-Raman spectroscopy was carried out at the edges of bilayer graphene. We find strong dependence of the intensity of the G band on the incident laser polarization, with its intensity dependence being 90° out of phase for the armchair and zigzag case, in accordance with theoretical predictions. For the case of mixed-state edges we demonstrate that the polarization contrast reflects the fractional composition of armchair and zigzag edges, providing a monitor of edge purity, which is an important parameter for the development of efficient nanoelectronic devices.
Direct Determination of Interface Structure and Bonding with the Scanning Transmission Electron Microscope (1996)

The scanning transmission electron microscope is capable of forming an electron probe of atomic dimensions, allowing incoherent imaging and microanalysis to be achieved at atomic resolution. Images formed using elastically scattered electrons show strong atomic number ( Z ) contrast and reveal atomic column locations without the need for preconceived structure models. Column positions and scattering power can be directly retrieved by a maximum entropy analysis. The Z -contrast image also allows the probe to be positioned with atomic precision over selected atomic columns or planes, making possible atomic-resolution electron energy loss spectroscopy. Interfacial structure and bonding can both be determined directly from experimental data, often leading to unexpected insights. In SrTiO 3 , grain boundary structural units were identified, and found to be reconstructed, an efficient way to overcome the problem of like-ion repulsion in ionic materials. At a CdTe-GaAs [001] interface, 60° dislocations were directly identified to be of glide type, while in the case of Lomer dislocations, an unexpected core structure was found comprising a fourfold ring structure. With these techniques, dislocation core structure and impurity segregation may be studied experimentally at the atomic scale.