gebhart/patrepeval huggingface dataset:
PSVIII-40 Stress alters bacterial density in the upper respiratory tract of beef calves. (2018)

Weaning and transportation are associated with an increased risk of bovine respiratory disease (BRD) in cattle. How these stressors increase the risk of BRD is not completely understood but dysbiosis of the upper respiratory tract (URT) microbiome is hypothesized to be one potential cause. This study explored the bacterial density dynamics in the URT of beef calves following weaning and transportation stress. Deep nasopharyngeal swabs were collected from 5- to 6-month-old beef calves [suckling/control (S, n=10), weaned/stress group 1 (W, n=10) and weaned plus transportation/stress group 2 (W+T, n=10)] before (d0) and after (d2, d4, d7, d14 and d28) subjecting to stressors. Total bacterial density and the density of Mannheimia heamolytica and Pasteurella multocida were estimated by quantitative real-time PCR. Bacterial density data were analyzed using a repeated measures experimental design with time as the repeated measurement and animal as the experimental unit. Significant temporal variations in estimated bacterial densities were observed, regardless of the treatment group. Total bacterial density was, however, significantly (P < 0.01) higher in suckling calves (log10 7.32 16S rRNA gene copy/swab) than stressed calves (W - log10 7.12 16S rRNA gene copy/swab; W+T - log10 7.18 16S rRNA gene copy/swab). In contrast, density of the potential pathogenic bacteria, M. heamolytica (S - log10 5.29 lktA gene copy/swab; W - log105.23 lktA gene copy/swab; W+T - log105.33 lktA gene copy/swab) and P. multocida (S - log105.34 16S rRNA gene copy/swab; W - log105.19 16S rRNA gene copy/swab; W+T - log105.36 16S rRNA gene copy/swab) were similar among groups. Whole genome sequencing of the URT microbiome is being completed to provide a greater understanding of URT microbiome dynamics and functional changes following stress. This knowledge will better elucidate impact of stress on the URT microbiome, especially the commensal bacteria that become opportunistic pathogens in the lung.
Elucidating the Mechanism of Silica Nanoparticle PEGylation Processes Using Fluorescence Correlation Spectroscopies (2016)

Surface modification with polyethylene glycol (PEG; PEGylation) is a widely used technique to improve nanoparticle (NP) stability, biocompatibility, and biodistribution profiles. In particular, PEGylation of silica surfaces and coatings plays a pivotal role across various classes of NPs. Despite the use of numerous protocols there is limited fundamental understanding of the mechanisms of these processes for NPs. Here, after reaction optimization for particle stability, we employ fluorescence correlation and cross-correlation spectroscopy (FCS, FCCS) on ultrasmall (<10 nm) fluorescent silica nanoparticles (SNPs) in water as a test bed. We show unexpected fast reaction kinetics in successful PEGylation observed even at nanomolar concentrations and attributed this to instant noncovalent adsorption of PEG molecules to the SNP surface preceding covalent attachment. Further studies of various reaction conditions enable the elucidation of process design criteria for NP PEGylation and surface modification with functional ligands, which may be applicable to a broad range of NPs thereby accelerating progress in fields ranging from biosensing to nanomedicine.
Catalysis and Mass Transport in Spatially Ordered Enzyme Assemblies on Electrodes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis and Mass Transport in Spatially Ordered Enzyme Assemblies on ElectrodesChristian Bourdillon, Christophe Demaille, Jacques Moiroux, and Jean-Michel SaveantCite this: J. Am. Chem. Soc. 1995, 117, 46, 11499–11506Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00151a013https://doi.org/10.1021/ja00151a013research-articleACS PublicationsRequest reuse permissionsArticle Views695Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures (1995)

Evidence from animal studies has led to the proposal that neuropeptide Y (NPY) has anxiolytic-like effects in rats after intracerebroventricular (i.c.v.) administration. The purpose of the present study was to extend these observations by examining the behavioral effects of a series of NPY receptor agonists including NPY, peptide YY (PYY), the NPY fragment 2-36 (NPY(2-36)), the Y(1) agonist [Leu(31), Pro(34)]-NPY and the Y(2) agonist NPY fragment 13-36 (NPY(13-36)), in two established anxiety models in rats: the elevated plus-maze and the fear-potentiated startle procedures. In the elevated plus-maze procedure, i.c.v. PYY (0.07-2.3nmol), NPY (0.07-2.3nmol), NPY(2-36) (0.07-2.3nmol). [Leu(31), Pro(34)]-NPY (0.7-7nmol), but not NPY(13-36) (0.7-7nmol), increased preference for the open arms of the plus-maze in a dose-dependent manner. In an acoustic startle paradigm, NPY, PYY and NPY(2-36) inhibited fear-potentiated startle over the dose-range of 0.23-2.3nmol. [Leu(31), Pro(34)]-NPY (2.3-13.2nmol) also attenuated fear-potentiated startle, whereas NPY(13-36) (up to 13.2nmol) had no effect. Taken together, these findings demonstrate that NPY, PYY and NPY(2-36) have anxiolytic-like effects that are likely mediated by Y(1) receptors.
082 Identification and Partial Characterization of Seasonally Regulated Proteins in Apple Bark Tissues (2000)

During autumnal leaf senescence, leaf nitrogen is translocated to bark and root tissues for storage. By definition, proteins that accumulate in large amounts in winter and are absent in summer are called storage proteins. These storage proteins are believed to play an important role in spring growth and helping trees to tolerate and/or recover from both abiotic and biotic stress. Little knowledge exists regarding storage proteins in apple, their physiological function, or how management practices impact them. Our objectives in this research was to characterize seasonally regulated proteins in apple, develop knowledge about their physiological function, and determine how they are affected by management practices. Results of the first-year studies have identified four major proteins that exhibit a seasonal pattern of accumulation in bark tissues of apple. One of these is a pathogenesis-related protein, meaning that it plays a role in disease resistance. Another of these proteins is a stress-related protein important in the use of carbohydrates under stress conditions. A third protein is a vegetative storage protein serving as a reserve for nitrogen. The last protein has not been completely identified. Greatest seasonal fluctuation of these proteins occurred in current season and 1-year-old bark tissues. Experimental studies that achieved varying levels of nitrogen in shoot tissues of young Fuji apple trees were examined for the effect on the accumulation of these proteins. Results indicated that despite a significant increase in total nitrogen, increases in the accumulation of these proteins were only slight. Instead, it appears that most of the nitrogen was present as free amino acids rather than stable proteins. These data indicate that more knowledge is required to determine the benefits and feasibility of elevating the levels of specific proteins in dormant apple trees or trying to manipulate the type of amino acids that accumulate.
Electron transfer between neptunium(VI) and substituted 1,10-phenanthroline and 2,2'-bipyridine complexes of iron(II) (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron transfer between neptunium(VI) and substituted 1,10-phenanthroline and 2,2'-bipyridine complexes of iron(II)E. Pelizzetti, M. Woods, and J. C. SullivanCite this: Inorg. Chem. 1981, 20, 11, 3973–3974Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ic50225a074https://doi.org/10.1021/ic50225a074research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: REACTION OF TRICARBONYL(η4‐6,6‐DIPHENYLPENTAFULVENE)IRON WITH NUCLEOPHILES (1981)

Abstract Anhand IR‐ sowie 1 H‐ und 13 C‐NMR‐spektroskopischer Untersuchungen wird gezeigt, daß die Reaktion des Titelkomplexes (I) mit Methanol/Methoxid über einen nucleophilen Angriff auf einen CO‐Liganden zum Metalloester (II) führt.
Gas-Phase Production of Nanoparticles (2002)

Gas-phase synthesis is a well-known chemical manufacturing technique for an extensive variety of nano-sized particles. Since the potential of ultra-fine and especially nano-sized particles in high-performance applications has been identified, the scientific and commercial interest has increased immensely, disclosing this field as a most important technology of the future.The paper will present the basics of the gas-phase synthesis and particle formation process including the relation between the principal process conditions and the product characteristics.Moreover, several reactor technologies such as flame, hot-wall, plasma and laser reactors will be introduced and their specific advantages will be pointed out. Precise process control is crucial in order to meet stringent specifications regarding the particles’ chemical composition and morphology.In addition, the paper will deal with some special nanoscaled gas-phase products of high innovative potential and their functional contribution in various applications.
A Simple Assay for Measuring Catalase Activity: A Visual Approach (2013)

In this study, an assay that combines the ease and simplicity of the qualitative approach for measuring catalase activity was developed. The assay reagents comprised only hydrogen peroxide and Triton X-100. The enzyme-generated oxygen bubbles trapped by Triton X-100 were visualized as foam, whose height was estimated. A calibration plot using the defined unit of catalase activity yielded the best linear fit over a range of 20-300 units (U) (y = 0.3794x - 2.0909, r(2) = 0.993). The assay precision and reproducibility at 100 U were 4.6% and 4.8%, respectively. The applicability of the assay for measuring the catalase activity of various samples was assessed using laboratory strains of Escherichia coli, catalase-deficient isogenic mutants, clinically isolated Shiga toxin-producing E. coli, and human cells. The assay generated reproducible results. In conclusion, this new assay can be used to measure the catalase activity of bacterial isolates and human cells.
Phylogenetic and Taxonomic Analyses of Rhodopirellula caenicola Sp. Nov., a New Marine Planctomycetes Species Isolated from Iron Sand (2015)

A Gram-negative, strictly aerobic, pink-pigmented, non-motile, spherical bacterium designated YM26-125 T was isolated from iron sand. Phylogenetic analyses based on the 16S rRNA gene sequence indicated that the new strain was affiliated with the phylum Planctomycetes and shared 96.1% sequence similarity with Rhodopirellula baltica SH 1 T . The strain could be also differentiated phenotypically from the Rhodopirellula baltica SH 1 T . The major fatty acids of strain YM26-125 T were identified as C16:0 and C18:1 9c as defined by the MIDI system. Amino acid analysis of cell wall hydrolysates indicated that the novel isolate did not contain diaminopimelic acid in their cell walls. The DNA G+C content was determined to be 57.5 mol%, the major respiratory quinone was identified as menaquinone 6 (MK-6) and a polar lipid profile was present consisting of a phosphatidylglycerol, a diphosphatidylglycerol and three unidentified phospholipids. From the distinct phylogenetic position and combination of genotypic and phenotypic characteristics, the strain is considered to represent a novel species for which the name Rhodopirellula caenicola sp. nov. is proposed. The type strain of R.
Regioselective photo-oxygenation of 2-aryl-4,5,6,7-tetrahydroindoles: preparation and reactions of 2-aryl-7a-hydroperoxy-4,5,6,7,7a-pentahydroindolenines (1983)

Dye-sensitized photo-oxygenation of 2-aryl-4,5,6,7-tetrahydroindoles quantitatively afforded 2-aryl-7a-hydroperoxy-4,5,6,7,7a-pentahydroindolenines, which were converted into the corresponding hydroxy-indolenines and spiro-γ-lactams in excellent yields.
Evaluation of biological fluid analysis using the sysmex XN automatic hematology analyzer (2017)

Except for AF, the Sysmex XN-1000 results agree with those of the manual method, although to different degrees depending on the fluid type. © 2017 International Clinical Cytometry Society.
Vector flow imaging using ultrasound: intraoperative estimation of blood flow in the ascending aorta compared to transesophageal echocardiography and pulmonary artery catheter thermodilution (2015)

Poster: ECR 2015 / C-0085 / Vector flow imaging using ultrasound: intraoperative estimation of blood flow in the ascending aorta compared to transesophageal echocardiography and pulmonary artery catheter thermodilution by: K. L. Hansen1, H. Moller-Sorensen1, J. Kjaergaard1, M. B. Jensen1, J. T. Lund1, J. A. Jensen2, M. B. Nielsen1; 1Copenhagen/DK, 2Kgs. Lyngby/DK
A Workflow Model for Designing and Managing Distributed Business Process in Virtual Enterprises (2002)

This papers introduces a research activity undertaken to identify the main strategies for enabling an easy and efficient integration among dispersed, heterogeneous workflow systems in virtual enterprises. It starts from the definition of the main features characterizing a virtual enterprise and from the main approaches to workflow designing. The main results are a taxonomy of the desirable characteristics of a workflow management system for virtual enterprises and an assessment of the workflowability of the virtual process.
Metabolic robustness in young roots underpins a predictive model of maize hybrid performance in the field (2017)

Heterosis has been extensively exploited for yield gain in maize (Zea mays L.). Here we conducted a comparative metabolomics-based analysis of young roots from in vitro germinating seedlings and from leaves of field-grown plants in a panel of inbred lines from the Dent and Flint heterotic patterns as well as selected F<sub>1</sub> hybrids. We found that metabolite levels in hybrids were more robust than in inbred lines. Using state-of-the-art modeling techniques, the most robust metabolites from roots and leaves explained up to 37 and 44% of the variance in the biomass from plants grown in two distinct field trials. In addition, a correlation-based analysis highlighted the trade-off between defense-related metabolites and hybrid performance. Therefore, our findings demonstrated the potential of metabolic profiles from young maize roots grown under tightly controlled conditions to predict hybrid performance in multiple field trials, thus bridging the greenhouse-field gap.
Conversational quality and visual interaction of video-telephony under synchronous and asynchronous transmission delay (2014)

In this study, the effect of pure synchronous and asynchronous transmission delay was examined in an interactive videotelephony setting. It was found that the conversational quality rated by participants of the study was clearly dependant on the tested conditions. This outcome can to some extend be ascribed to the used task which facilitated the usage of the visual channel for social interaction. Besides the conversational quality, a measure to quantify visual interaction was investigated for the first time in delayed mediated communication. The overall motion extracted from the recorded videos increased if synchronous transmission delays were inserted in the video-telephony connection.
ChemInform Abstract: A New Candidate for a Properly Substituted CD Ring Component of Vitamin D3 via Intramolecular Asymmetric Olefination of a 1,3‐ Cyclopentanedione Derivative. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts (2014)

Chronic coronary heart disease (cCHD) is characterized by atherosclerosis, which progressively narrows the coronary artery lumen and impairs myocardial blood flow. Restoration of occluded coronary vessels with newly formed collaterals remains an ideal therapeutic approach due to the need for redirecting blood flow into the ischemic heart. In this study, we investigated the effect of an active fraction isolated from Geum joponicum (AFGJ) on angiogenesis in cCHD hearts. Our results demonstrated that AFGJ not only enhanced capillary tube formation of endothelial cells, but also promoted the growth of new coronary collaterals (at the diameter 0.021-0.21 mm) in the ischemic region of hearts in rat cCHD model. Our study also indicated that the growth of new collaterals in ischemic hearts resulted in improved functional recovery of the cCHD hearts as demonstrated by ECG and echocardiography analyses. These data suggest that AFGJ may provide a novel therapeutic method for effective treatment of cCHD.
Proceedings: Intermolecular heterogeneity of the carcinoembryonic antigen. (1974)

Summary Studies were performed to determine the degree of heterogeneity within any one preparation of purified carcinoembryonic antigen (CEA) of the human digestive system and the variations in chemical composition between such preparations. Individual batches of CEA, isolated from hepatic metastases arising from adenocarcinomas of either the colon or stomach, were examined by a number of physicochemical and immunochemical parameters. Among the differences observed were the carbohydrate/protein ratio and the quantities of the individual amino acid and monosaccharide residues in the different purified preparations examined. These variations, in turn, were responsible for the secondary manifestations of heterogeneity observed upon gel electrophoresis. The polydisperse nature of the electrophoretic pattern of each of the purified CEA preparations upon alkaline polyacrylamide gel electrophoresis was largely due to variations in the sialic acid content of individual CEA molecules. In addition, the molecular size and antigenicity of the CEA varied, to some degree, from preparation to preparation. Nevertheless, colon tumors as a group were far more similar to one another than they were to the gastric tumor preparation studied. The observations made demonstrate the overall complexity of the structure of the CEA molecule, obtained from different sources, but they also serve to elucidate certain of the parameters by which this molecular moiety may be defined.
Unsupervised End-To-End Groupwise Registration Framework Without Generating Templates (2020)

Groupwise registration is an important and challenging task for medical image processing and analysis. Traditional methods focus on generating a template and performing pairwise registration, which can be time-consuming to converge. In this paper, we propose an unsupervised end-to-end group-wise registration framework with multi-step mechanisms to progressively refine outputs. The framework can generate the displacement field for each subject directly without templates. Customized loss functions are designed to optimize the model and reduce the bias of generated common space. We experiment on 2D brain MRI coronal slices from OASIS and compare the results with two baseline methods using Dice score criterion. Results show that our framework achieves state-of-the-art performance with a much lower time cost.
Virtual Reality for Information Visualization Might Just Work This Time (2019)

In the 1990's, Virtual Reality (VR) was discredited as a means of presenting Information Visualization (InfoViz). Mercurio and Erickon (Mercurio et al., 1990), noted several problems required to be overcome before the potential of VR for scientific visualization could be realized: low image resolution, user navigation, small tracking volume, low tracker update rate, and poor user interfaces. Even with this negative reaction, a number of researchers continued pursuing this line of investigation (for example, the work of Bowman et al., 2003). As hardware and graphics techniques improved, plausible applicability of VR to InfoViz was slowly being realized. Currently, Immersive Analytics (Marriott et al., 2018) is an emerging direction for the use of VR and other immersive technologies to improve understanding of visualization problems.
A Flexible GPS Software Development System and Timing Analyzer for Present and Future Microprocessors (1984)

Discussed is a timing emulation and operating system which predicts loading for microprocessors and enables efficient generation of software found in such applications as the Global Positioning System. The timing emulator is applied to two classes of user equipment, a conventional fast-multiplexed design and a fully integrated processor featuring continuous state feedback into the spread-spectrum demodulation and tracking loops. Timing data are developed for five representative microprocessors ranging from 8/8 to 32/32 register/bus widths. The advanced integrated processor requires augmentation of the 32/32 processor with a math coprocessor. The emulator is used to develop speed requirements on the co-processor. Lastly, the software development system is described. This contains a multi-tasking operating system and matrix library written in the language “C” which may be easily adapted to a range of radio-navigation problems.
FNV: light-weight flash-based network and pathway viewer (2011)

avi.maayan@mssm.edu.