gebhart/patrepeval huggingface dataset:
Transplantation of human skin microbiota in models of atopic dermatitis (2016)

Atopic dermatitis (AD) is characterized by reduced barrier function, reduced innate immune activation, and susceptibility to <i>Staphylococcus aureus</i>. Host susceptibility factors are suggested by monogenic disorders associated with AD-like phenotypes and can be medically modulated. <i>S. aureus</i> contributes to AD pathogenesis and can be mitigated by antibiotics and bleach baths. Recent work has revealed that the skin microbiome differs significantly between healthy controls and patients with AD, including decreased Gram-negative bacteria in AD. However, little is known about the potential therapeutic benefit of microbiome modulation. To evaluate whether parameters of AD pathogenesis are altered after exposure to different culturable Gram-negative bacteria (CGN) collected from human skin, CGN were collected from healthy controls and patients with AD. Then, effects on cellular and culture-based models of immune, epithelial, and bacterial function were evaluated. Representative strains were evaluated in the MC903 mouse model of AD. We found that CGN taken from healthy volunteers but not from patients with AD were associated with enhanced barrier function, innate immunity activation, and control of <i>S. aureus</i>. Treatment with CGN from healthy controls improved outcomes in a mouse model of AD. These findings suggest that a live-biotherapeutic approach may hold promise for treatment of patients with AD.
Heat strain imposed by toxic agent protective systems. (2001)

This study evaluated physiological heat strain from two developmental toxic agent protective systems compared with the standard Toxicological Agent Protective (TAP) suit during exercise-heat stress. Eight subjects (six men, two women) completed three experimental trials, at 38 degrees C, 30% rh, wearing: 1) Self Contained Toxic Environment Protective Outfit (STEPO) with rebreather (STEPO-R); 2) STEPO with tether (STEPO-T) or 3) the standard TAP. The STEPO systems provided effective body cooling of: STEPO-R, 200 +/- 36 W; and STEPO-T, 186 +/- 59 W. TAP had no cooling. All experimental trials used treadmill walking at 0.89 m x s(-1), 0% grade at exercise/rest cycles of 20/10 min for 240 min. Metabolic rates for the treatments were: STEPO-R, 298 +/- 26 W; STEPO-T, 299 +/- 34 W; and TAP, 222 +/- 40 W. Rate of heat storage was less (p < 0.05) in STEPO-R (37 +/- 8 W x m(-2)) and STEPO-T (38 +/- 12 W x m(-2)) than in TAP (77 +/- 15 W x m(-2)). Sweating rate was less (p < 0.05) in STEPO-T (10.0 +/- 4.8 g x min(-1)) than in TAP (23.8 x 11.4 g x min(-1)). There was no difference between STEPO-R (12.3 +/- 5.6 g min(-1)) and the other two uniform systems. Subjects did not complete targeted exposure times of 240 min. Exposure time was longer (p < 0.05) in STEPO-R (83 +/- 22 min) and STEPO-T (106 +/- 39 min) than in TAP (46 +/- 10 min). Predicted time to 39.0 degrees C was less (p < 0.05) in TAP (69 +/- 20 min) than in either STEPO-R (226 +/- 124 min) or STEPO-T (244 +/- 170 min). The results of this study show that cooling in STEPO significantly reduced heat storage relative to TAP. The new generation toxic cleanup uniform systems effectively reduced heat stress and increased work capabilities compared with the standard TAP suit.
Closing the Network Diagnostics Gap with Vigil (2017)

poster Public Access Share on Closing the Network Diagnostics Gap with Vigil Authors: Behnaz Arzani University of Pennsylvania University of PennsylvaniaView Profile , Selim Ciraci Microsoft MicrosoftView Profile , Luiz Chamon University of Pennsylvania University of PennsylvaniaView Profile , Yibo Zhu Microsoft Research Microsoft ResearchView Profile , Hongqiang Liu Microsoft Research Microsoft ResearchView Profile , Jitu Padhye Microsoft Research Microsoft ResearchView Profile , Geoff Outhred Microsoft MicrosoftView Profile , Boon Thau Loo University of Pennsylvania University of PennsylvaniaView Profile Authors Info & Claims SIGCOMM Posters and Demos '17: Proceedings of the SIGCOMM Posters and DemosAugust 2017 Pages 40–42https://doi.org/10.1145/3123878.3131979Published:22 August 2017Publication History 3citation295DownloadsMetricsTotal Citations3Total Downloads295Last 12 Months19Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Coherent Sub-Aperture Processing Techniques for Synthetic Aperture Radar (1984)

Coherent sub-aperture techniques for processing synthetic aperture radar (SAR) signals are described. The techniques involve partitioning the full aperture data, in either the time or the frequency domain, Each partition or sub-aperture is then processed independently by the application of a conventional matched filter, or the equivalent. The low resolution images formed by this process are then coherently recombined to form a full resolution image. Such a processing scheme has the advantage of high computational efficiency and provides the capability for the compensation of low frequency spurious motions, even when the SAR is operating in a highly squinted, high resolution imaging situation. A detailed description of two coherent sub-aperture techniques namely, the multi-look matched filtering approach and the step transform, are presented. The techniques are characterized and the normal computational requirements are evaluated. Computer simulations, which were performed to verify the feasibility for the processing schemes, are also described.
Analysis of steady-state segment storage utilizations in a log-structured file system with least-utilized segment cleaning (1996)

The steady-state distribution of storage utilizations of segments in a log-structured file system with least-utilized (greedy) segment cleaning is found using analytic methods. Furthermore, it is shown that as the number of segments increases, this distribution approaches a limiting continuous distribution, which is also derived. These results could be useful for preliminary performance analysis of LFS-type system designs prior to the development of detailed simulation models or actual implementation.
The structure of Inter-Urban traffic: A weighted network analysis (2005)

We study the structure of the network representing the interurban commuting traffic of the Sardinia region, Italy, which amounts to 375 municipalities and 1,600,000 inhabitants. We use a weighted network representation where vertices correspond to towns and the edges to the actual commuting flows among those. We characterize quantitatively both the topological and weighted properties of the resulting network. Interestingly, the statistical properties of commuting traffic exhibit complex features and non-trivial relations with the underlying topology. We characterize quantitatively the traffic backbone among large cities and we give evidences for a very high heterogeneity of the commuter flows around large cities. We also discuss the interplay between the topological and dynamical properties of the network as well as their relation with socio-demographic variables such as population and monthly income. This analysis may be useful at various stages in environmental planning and provides analytical tools for a wide spectrum of applications ranging from impact evaluation to decision-making and planning support.
Synthesis, spectral properties, and pesticidal activity of 4-amino(alkylamino, dialkylamino)-5-chloro-2-substituted-3-oxo-2H-pyridazines and 5-amino(alkylamino, dialkylamino)-4-chloro-2-substituted-3-oxo-2H-pyridazines (1985)

4-Amino(alkylamino)-5-chloro-2-substituted-3-oxo-2 H -pyridazines and 5-amino(alkylamino, dialkylamino)-4-chloro-2-substituted-3-oxo-2 H -pyridazines have been prepared by nucleophilic substitution reactions of 4,5-dichloro-2-substituted-3-oxo-2 H -pyridazines with amines in aprotic solvent. Structure of the compounds prepared has been proved by IR and UV spectra. Fungicidal and herbicidal activity of the compounds prepared have been tested. None of the compounds prepared exceeds the standard Vitavax in the fungicidal activity tests. Compounds VIII and XII show equal or better activity on the Hill reaction as compared with the standard pyrazone.
Towards Wind Vector and Wave Height Retrievals Over Inland Waters Using CYGNSS (2021)

GNSS Reflectometry (GNSS-R) measurements over inland water bodies, such as lakes, rivers, and wetlands exhibit strong coherent signals. The strength of the coherent reflections is highly sensitive to small-scale surface roughness. For inland waters, this roughness is primarily due to wind-driven surface waves. The sensitivity of the coherent reflections to surface roughness can be leveraged to estimate wave height profiles across inland waters. Coupled with a wind wave model, an approach to retrieve a wind vector is described using a forward model, which is potentially able to predict scattered power profiles for different wind speeds and directions and choosing the minimum-squared error solution. The ability for spaceborne or airborne GNSS-R to measure an inland water wind vector and wave heights could contribute to scientific applications focused on understanding nearshore ecosystems, monitoring climate change effects on inland waters, sediment resuspension, biomass production, fish habitat, and others. This paper presents a novel approach to potentially retrieve wind vector and wave heights over inland waters using GNSS-R and discusses the issues with performing such retrievals using simulation and very few available raw signals recorded from CYGNSS satellites.
Re: 45,X Karyotype in an Infertile Man: How is this Possible? (2014)

No AccessJournal of UrologyAdult Urology1 Feb 2015Re: 45,X Karyotype in an Infertile Man: How is this Possible? Craig NiederbergerMD Craig NiederbergerCraig Niederberger More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.11.051AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: 45,X Karyotype in an Infertile Man: How is this Possible?." The Journal of Urology, 193(2), p. 628 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 2February 2015Page: 628Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Craig Niederberger More articles by this author Expand All Advertisement PDF downloadLoading ...
Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. (1990)

Sera from patients with dihydralazine-induced hepatitis were shown to contain anti-liver microsomal autoantibodies (anti-LM) by indirect immunofluorescence. These anti-LM antibodies were different from anti-liver/kidney microsomes (anti-LKM) 1 or 2 autoantibodies which have been previously described. Sera recognized a single 53,000 = Mr polypeptide in human liver microsomes as judged by immunoblotting, and the target antigen was identified as cytochrome P-450IA2 (P-450IA2) by (a) comparison of immunoblotting patterns with anti-human P-450IA2 and anti-rat P-450IA2 and with five anti-LM sera, and (b) specific immunoinhibition of microsomal ethoxyresorufin and phenacetin O-deethylation activities (both P-450IA2 supported reactions) by anti-LM antibodies. Finally, purified human P-450IA2 was recognized by these anti-LM sera. The anti-LM antibodies are specific for the disease because none of the other antisera tested behaved in the same manner as anti-LM, even those from patients treated with dihydralazine and without hepatic disease. A possible role of P-450IA2 in the metabolism of dihydralazine was suggested by competitive inhibition of ethoxyresorufin-O-deethylase observed in microsomal incubations. Thus, a new example is presented in which a cytochrome P-450 may be a target for autoantibodies in drug-induced hepatitis.
Thermal Treatment of Poly (N -vinylformamide) Produced Hydrogels Without the Use of Chemical Crosslinkers (2017)

Hydrogel preparations using poly(N-vinylformamide) (PNVF) and poly(N-vinylacetamide) (PNVA), which are composed of non-conjugated vinyl monomers, N-vinylformamide (NVF) and N-vinylacetamide (NVA), were investigated without chemical crosslinkers. Hydrogen bonding interaction between the polymers and poly(ethylene glycol) have been firstly attempted to result in unstable film, which is easily soluble in water. On the other hand, the simple thermal treatment of the PNVF films at 200 °C for several hours produced the hydrogels after water immersion, although PNVA did not produce any hydrogels under the same condition. The swelling ratios of the formed hydrogel ranged from 100 to 250. The analysis of the supernatant reveals the structural change at alpha proton of PNVF. Furthermore, the decrease of molecular weights were observed by SEC analysis when the hydrogels formed. The possible mechanism of the crosslinking reaction is also discussed. The present study provides the novel method to prepare PNVF hydrogels without the use of chemical crosslinkers.
Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma (2021)

Pyrazolopyrimidinones are fused nitrogen-containing heterocyclic systems, which act as a core scaffold in many pharmaceutically relevant compounds. Pyrazolopyrimidinones have been demonstrated to be efficient in treating several diseases, including cystic fibrosis, obesity, viral infection and cancer. In this study using glioblastoma U-251MG cell line, we tested the cytotoxic effects of 15 pyrazolopyrimidinones, synthesised via a two-step process, in combination with cold atmospheric plasma (CAP). CAP is an adjustable source of reactive oxygen and nitrogen species as well as other unique chemical and physical effects which has been successfully tested as an innovative cancer therapy in clinical trials. Significantly variable cytotoxicity was observed with IC<sub>50</sub> values ranging from around 11 μM to negligible toxicity among tested compounds. Interestingly, two pyrazolopyrimidinones were identified that act in a prodrug fashion and display around 5-15 times enhanced reactive-species dependent cytotoxicity when combined with cold atmospheric plasma. Activation was evident for direct CAP treatment on U-251MG cells loaded with the pyrazolopyrimidinone and indirect CAP treatment of the pyrazolopyrimidinone in media before adding to cells. Our results demonstrated the potential of CAP combined with pyrazolopyrimidinones as a programmable cytotoxic therapy and provide screened scaffolds that can be used for further development of pyrazolopyrimidinone prodrug derivatives.
Studies on sonodynamic cancer therapy (1992)

Chemical agents such as hematoporphyrin have been found to have a sonochemical activity to induce anti-tumor effects. The same kind of sonochemical reactions producing active oxygen species has been demonstrated to be localized with a highly focused ultrasound in a specially developed tissue-mimicking phantom. These results suggest that the focused ultrasound irradiation to a tumor combined with administration of such a sonochemically active agent can be a potential low-invasive modality for cancer therapy.
MOS C-V characterization of ultrathin gate oxide thickness (1.3-1.8 nm) (1999)

An equivalent circuit approach to MOS capacitance-voltage (C-V) modeling of ultrathin gate oxides (1.3-1.8 nm) is proposed. Capacitance simulation including polysilicon depletion is based on quantum mechanical (QM) corrections implemented in a two-dimensional (2-D) device simulator; tunneling current is calculated using a one-dimensional (1-D) Green's function solver. The sharp decrease in capacitance observed for gate oxides below 2.0 nm in both accumulation and inversion is modeled using distributed voltage-controlled RC networks. The imaginary components of small-signal input admittance obtained from AC network analysis agree well with measured capacitance.
Bends and splitters in metal-dielectric-metal subwavelength plasmonic waveguides (2005)

We investigate the performance of bends and splitters in metal-dielectric-metal subwavelength plasmonic waveguides. We show that bends and splitters with no additional loss over a very wide frequency range can be designed for metal-dielectric-metal waveguides with center layer thickness small compared to the wavelength. We also introduce the concept of characteristic impedance for such systems to account for their behavior.
Study on regeneration of spent hydrochloric acid in chemical coal leaching process (2018)

For Indian coals, chemical leaching process has better advantage over the conventional physical cleaning techniques due to its drift origin. Coal leaching is a two-stage process where alkali and acid leaching cycles are used, where most of the ash constituents are accumulated in the spent acid and hence purification of spent acid containing silica, alumina, iron, calcium and magnesium is of great importance. Four different methods namely adsorption using activated carbon, ion exchange with anion exchange resin, pyrohydrolysis and stage-wise neutralisation are studied. Results with adsorption and ion exchange techniques are poor and a maximum of 50% removal is observed. Results indicate that, pyrohydrolysis shows better performance with > 99% pure hydrochloric acid as product but it is energy intensive. Stage-wise neutralisation technique is promising for dilute acid, where silica is precipitated by digestion and it produces magnesium oxide and calcium salt with 86.7% and 93.86% purity respectively.
Exploring the Effects of Class-Specific Augmentation and Class Coalescence on Deep Neural Network Performance Using a Novel Road Feature Dataset (2018)

The identification of nodal road network features in remote sensing imagery is an important object detection task due to its versatility of application. A successful capability enables urban sprawl tracking, automatic or semi-automated map accuracy validation and updating, and macro-scale infrastructure damage evaluation and tracking just to name a few. We have curated a custom, novel dataset that includes nodal road network features such as bridges, cul-de-sacs, freeway exchanges and exits, freeway overpasses, intersections, and traffic circles. From this curated data we have evaluated the use of deep machine learning for object recognition across two variations in this image dataset. These variations are expanded versus semantically coalesced classes. We have evaluated the performance of two deep convolutional neural networks, ResNet50 and Xception, to detect these features across these variations of the image datasets. We have also explored the use of class-specific data augmentation to improve the performance of the models trained for nodal road network feature detection. Cross-validation performance of the models evaluated on four variations of this nodal road network feature dataset range from 0.81 to 0.96 (F1 scores). Coalescing highly specific, semantically challenging classes into more semantically generalized classes has a significant impact on the accuracy of the models. Our analysis provides insight into if and how these techniques can improve the performance of machine learning models, facilitating application to broad area imagery analysis in numerous application domains.
PB1828: CADENZA: A PIVOTAL STUDY OF PIVEKIMAB SUNIRINE (IMGN632) IN PATIENTS WITH UNTREATED/FRONTLINE BPDCN (2022)

Background: Overexpression of CD123 occurs in multiple hematological malignancies, including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and others. With limited expression on normal hematopoietic progenitor cells, the CD123 antigen is an attractive target for new therapeutics. IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a peptide linker, to a unique DNA-alkylating cytotoxic payload of the IGN (indolinobenzodiazepine pseudodimer) class. Preclinically, IMGN632 has demonstrated potent activity against BPDCN, AML, and ALL models, with a wide therapeutic index in animal models, as well as 150-fold differential cytotoxicity in AML patient-derived samples compared to normal hematopoietic progenitors (Kovtun. Blood Adv (2018) 2(8):848, Angelova. Haematologica (2019) 104(4):749). In particular, remarkable sensitivity of BPDCN patient-derived xenografts to IMGN632 was demonstrated (Zhang Blood (2018) 132:3956). The clinical safety profile of IMGN632 in BPDCN is characterized by low-grade peripheral edema and infusion reactions, and reversible veno-occlusive disease in < 5%; there have been no capillary leak syndrome and no treatment-related deaths. Data in relapsed or refractory BPDCN led to FDA granting of Breakthrough Therapy Designation for IMGN632 (October 2020). We have previously reported three of three frontline BPDCN patients achieved clinical complete responses (CRc) with duration of response (DOR) of up to 10.7 months without transplant (Pemmaraju. ASH 2021 Abstract #1284). Aims: This study is designed to determine the safety, tolerability, and activity of IMGN632 when administered to patients with frontline BPDCN. Methods: The dose escalation phase identified a recommended phase 2 dose of 0.045 mg/kg given intravenously every 3 weeks. Expansion cohorts include a pivotal cohort for frontline/untreated BPDCN (no prior systemic therapy), and exploratory cohorts for patients with relapsed or refractory BPDCN. Patients with central nervous system disease are not eligible in the frontline BPDCN cohort. Results: N/A Summary/Conclusion: Enrollment continues in the pivotal cohort for frontline/untreated BPDCN patients. CADENZA, https://BPDCNtrial.com, NCT03386513
Internal avalanches in models of granular media (1998)

We study the phenomenon of internal avalanching within the context of recently introduced lattice models of granular media. The avalanche is produced by pulling out a grain at the base of the packing and studying how many grains have to rearrange before the packing is once more stable. We find that the avalanches are long-ranged, decaying as a power-law. We study the distriution of avalanches as a function of the density of the packing and find that the avalanche distribution is a very sensitive structural probe of the system.
Dopamine D2-Subtype Receptors Outside the Blood-Brain Barrier Mediate Enhancement of Mesolimbic Dopamine Release and Conditioned Place Preference by Intravenous Dopamine (2022)

Dopamine (DA) is a cell-signaling molecule that does not readily cross the blood-brain barrier. Despite this, peripherally administered DA enhances DA levels in the nucleus accumbens and alters DA-related behaviors. This study was designed to investigate whether DA subtype-2 receptors are involved in the enhancement of nucleus accumbens (NAc) DA levels elicited by intravenous DA administration. This was accomplished by using microdialysis in the NAc and extracellular single unit recordings of putative DA neurons in the ventral tegmental area (VTA). Additionally, the reinforcing properties of intravenous DA were investigated using a place conditioning paradigm and the effects of intravenous DA on ultrasonic vocalizations were assessed. Following administration of intravenous dopamine, the firing rate of putative DA neurons in the VTA displayed a biphasic response and DA levels in the nucleus accumbens were enhanced. Pretreatment with domperidone, a peripheral-only DA D2 receptor (D2R) antagonist, reduced intravenous DA mediated increases in VTA DA neuron activity and NAc DA levels. Pretreatment with phentolamine, a peripheral α-adrenergic receptor antagonist, did not alter the effects of IV DA on mesolimbic DA neurotransmission. These results provide evidence for peripheral D2R mediation of the effects of intravenous DA on mesolimbic DA signaling.