gebhart/patrepeval huggingface dataset:
Effects of High Molecular Weight Urinary Macromolecules on Crystallization of Calcium Oxalate Dihydrate (1982)

Timed urinary collections from 8 normal (Nl) persons of 11 stone forming (SF) patients were passed through ultrafiltration apparatus to remove macromolecules in the ranges 1000-30,000 d, 30,000-50,000 d, and over 50,000 d. No macromolecules could be recovered from either group in the 30,000-50,000 d range, and no low molecular weight macromolecules (LMWMM) (less than 30,000 d) were recovered from stone forming urines. Significant amounts of LMWMM (mean 105.8 +/- 17.63 mg./l.) were recovered from normal urine, but these extracts had no effects on calcium oxalate dihydrate (COD) nucleation (Bo) or linear growth (G) rates in a continuous crystallization (MSMPR) system. Urines from SF contained nearly twice the concentration of high molecular weight macromolecules (HMWMM) when compared to Nl urines. SF HMWMM differed from Nl in immunoelectrophoresis separation by absence of a dense band that was present in Nl extracts. This band reappeared in SF extract after boiling. Comparison of effects of addition of SF or Nl HMWMM to the COD-MSMPR crystallization system revealed no major quantitative differences in Bo or G, but SF HMWMM had a remarkable stabilizing effect on total mass (MT) of COD crystals produced. This effect was confirmed by analysis of oxalate residual supersaturation after crystallization. We conclude that SF excrete higher concentrations of HMWMM and almost no LMWMM when compared to normals. This higher concentration of HMWMM must contribute to increased Bo and decreased G noted in SF urine additive experiments previously reported. The mechanism of rapid removal of oxalate (i,e, stabilization) noted in experiments with SF HMWMM is not obvious at this time.
SenseCam: A wearable camera that stimulates and rehabilitates autobiographical memory (2011)

SenseCam is a wearable digital camera that captures an electronic record of the wearer's day. It does this by automatically recording a series of still images through its wide-angle lens, and simultaneously capturing a log of data from a number of built-in electronic sensors. Subsequently reviewing a sequence of images appears to provide a powerful autobiographical memory cue. A preliminary evaluation of SenseCam with a patient diagnosed with severe memory impairment was extremely positive; periodic review of images of events recorded by SenseCam resulted in significant recall of those events. Following this, a great deal of work has been undertaken to explore this phenomenon and there are early indications that SenseCam technology may be beneficial to a variety of patients with physical and mental health problems, and is valuable as a tool for investigating normal memory through behavioural and neuroimaging means. Elsewhere, it is becoming clear that judicious use of SenseCam could significantly impact the study of human behaviour. Meanwhile, research and development of the technology itself continues with the aim of providing robust hardware and software tools to meet the needs of clinicians, patients, carers, and researchers. In this paper we describe the history of SenseCam, and the design and operation of the SenseCam device and the associated viewing software, and we discuss some of the ongoing research questions being addressed with the help of SenseCam.
Range-Adaptive Wireless Power Transfer Based on Differential Coupling Using Multiple Bidirectional Coils (2019)

Wireless power transfer systems using coupled magnetic resonances are susceptible to the transfer distance variation between the transmitter (Tx) and receiver (Rx) since the coupling between Tx and Rx is highly position dependent. Once the transfer distance deviates from the optimum one, the coupling will be either excessive or weak, which results in power transfer efficiency (PTE) degradation. This article presents a Tx structure consisting of multiple subcoils oriented in opposite directions to keep the coupling relatively constant over an extensive range of transfer distances. The proposed design can achieve a PTE of 88-70% with a transfer distance varying from 0 to 70 mm and a PTE of 85-60% with a misalignment of 0-80 mm at a 40 mm transfer distance. The radius of the Tx and Rx is 84.6 and 45.1 mm, respectively. The measured PTE of the proposed design is better than 70% with a 0-50 mm transfer distance while the misalignment changing from 0 to 50 mm. The proposed system is much less sensitive to the transfer distance variation than the convention system and has a great potential for wireless charging applications.
Pitch Histogram Based Analysis Of Makam Music In Turkey (2014)

<strong>Abstract:</strong> Compared to the volume of research on Western music, computational studies on Makam Music in Turkey (MMT) is almost extinct. In this text we present an overview of our pitch histogram based analysis methods. An automatic tonic detection method and its various applications are presented.
The Postinjury Inflammatory State and the Bone Marrow Response to Anemia (2018)

Severe blunt trauma was associated with neuroendocrine activation, erythropoietin dysfunction, iron dysregulation, erythroid progenitor growth suppression, and persistent injury-associated anemia. Clinical trial registered with www.clinicaltrials.gov (NCT 02577731).
A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression (2015)

Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of action is still unknown. It has been suggested that many anti-depressants act by increasing the concentrations of serotonergic transmitters in the synaptic space. However, recent studies have examined the effects of anti-depressants on neurogenesis in the hippocampus, the restoration of hippocampal neuronal networks that may be affected by major depression, and the regulation of the hypothalamic-pituitary-adrenal axis by immature neurons in the hippocampus. Here, we present and discuss a novel hypothesis suggesting that these events are regulated by the concentrations of sphingolipids, in particular ceramide, in the hippocampus. These concepts suggest that the acid sphingomyelinase/ceramide system plays a central role in the pathogenesis of major depression and may be a novel target for anti-depressants.
Tritium nuclear magnetic resonance spectroscopy. Part 10. Distribution of tritium in some labelled nitrogen heterocyclic compounds (1979)

Pyridine, methylpyridines, quinoline, isoquinoline, phenanthridine, and nicotine have been labelled with tritium, using pre-reduced platinum dioxide and tritiated water. The regiospecificity and extent of labelling have been determined directly by 3H n.m.r. In instances of non-uniform labelling, the predominant effect seems to have a steric origin. The hydrogen chemical shifts for phenanthridine are reported for the first time.
Coping Strategies of Secondary School Children in Response to Being Bullied (2001)

Through a questionnaire survey, the present study investigated the coping strategies of Year 7 (11–12 years old) and Year 9 (13–14 years old) pupils (N = 324) to find out what strategies they have used to overcome the difficulties of being bullied by peers. Fifty-one UK secondary schools, in each of which an anti-bullying peer support system had been in place for at least a year, participated. The coping strategies of those pupils who said that they had told someone (N = 279) about being bullied were compared with those who said that they had not (N = 45). These coping strategies differ, not only according to whether or not they report the bullying, but also according to their age and gender. Implications of the findings for professionals who work with children and adolescents are suggested.
A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis (2006)

Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.
Design Strategies of Biodegradable Scaffolds for Tissue Regeneration (2014)

There are numerous available biodegradable materials that can be used as scaffolds in regenerative medicine. Currently, there is a huge emphasis on the designing phase of the scaffolds. Materials can be designed to have different properties in order to match the specific application. Modifying scaffolds enhances their bioactivity and improves the regeneration capacity. Modifications of the scaffolds can be later characterized using several tissue engineering tools. In addition to the material, cell source is an important component of the regeneration process. Modified materials must be able to support survival and growth of different cell types. Together, cells and modified biomaterials contribute to the remodeling of the engineered tissue, which affects its performance. This review focuses on the recent advancements in the designs of the scaffolds including the physical and chemical modifications. The last part of this review also discusses designing processes that involve viability of cells.
A Structural Perspective on the Interaction between Lipopolysaccharide and Factor C, a Receptor Involved in Recognition of Gram-negative Bacteria (2006)

The recognition of broadly conserved microorganism components known as pathogen-associated molecular patterns is an essential step in initiating the innate immune response. In the horseshoe crab, stimulation of hemocytes with lipopolysaccharide (LPS) causes the activation of its innate immune response, and Factor C, a serine protease zymogen, plays an important role in this event. Here, we report that Factor C associates with LPS on the hemocyte surface and directly recognizes Gram-negative bacteria. Structure-function analyses reveal that the LPS binding site is present in the N-terminal cysteine-rich (Cys-rich) region of the molecule and that it contains a tripeptide sequence consisting of an aromatic residue flanked by two basic residues that is conserved in other mammalian LPS-recognizing proteins. Moreover, we have demonstrated that the Cys-rich region specifically binds to LPS on Gram-negative bacteria and that mutations in the tripeptide motif abrogate its association with both LPS and Gram-negative bacteria, underscoring the importance of the tripeptide in LPS interaction. Although the innate immune response to LPS in the horseshoe crab is distinct from that of mammals, it appears to rely on structural features that are conserved among LPS-recognizing proteins from diverse species.
ChemInform Abstract: Baylis‐Hillman Reaction: Magnesium Bromide as a Stereoselective Reagent for the Synthesis of (E)‐ and (Z)‐Allyl Bromides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Numerical analysis of negative ion temperature in a negative ion source (2004)

To understand the origin of the two energy groups of volume produced H− ions observed in the multicusp, hybrid-type H− ion source (Camembert III), numerical analysis by the three-dimensional Monte Carlo simulation code has been done. Realistic multicusp geometry and the electric field near the filament are taken into account in the model. The energy relaxation process by Coulomb collision is also included in the model by the Monte Carlo method. Under the typical low-pressure condition of Camembert III, high-energy H− ions are clearly observed in the central region. The origin of these high-energy H− ions is possibly explained by the combined effects of (1) acceleration by electric field near the filament and (2) relatively large energy-loss time of these high-energy H− ions. However, the low energy group is not clearly observed in the simulation. The low energy H− ions with original energy (∼0.05 eV) have enough time to relax their energy towards the relatively high temperature of the background H+ ions, because their energy relaxation time is much smaller than the confinement time.
The TSH receptor: Structure and interaction with autoantibodies in thyroid disease (1987)

Studies of the TSH receptor using affinity labelling with photoactive derivatives of TSH and analysis by SDS-PAGE have shown that the receptor contains 2 subunits (A and B), linked by a disulphide bridge. Similar results are obtained with TSH receptors from human, porcine and guinea pig thyroid tissue and from guinea pig fat. Analysis of affinity labelled receptors under non-denaturing conditions suggest that subunits additional to the A and B subunits are not present. Hydrodynamic measurements indicate that the receptor A subunit has an approximately spherical structure (Stokes' radius 70 A) and when this interacts with TSH (an elongated structure with Stokes' radius 56A) a very elongated complex (Stokes' radius 104A) is formed. Isoelectric focusing studies of the TSH receptor A subunit, TSH and TSH receptor antibodies indicate that charge-charge interactions are of considerable importance in the binding of hormone and antibody to the receptor.
Abstract 105: Chagas Disease: an Independent Mortality Risk Factor for Patients with Pacemakers? (2014)

Background: Almost 25% of patients with Chagas disease (CD) have some degree of cardiac compromise, including rhythm disturbances, which ultimately may require permanent pacemaker (PPM) implantation. CD has been shown to be an independent risk factor for mortality in heart failure. In PPM patients the prognostic significance of CD seropositivity is yet to be determined. Methods: Patients from a highly endemic region for CD with a PPM were divided into two groups: those with CD confirmed by immunofluorescence and those without CD. Patients were followed for a 3-year period. Cox proportional-hazards model and Kaplan-Meier method with log-rank test for mortality were calculated. Results: A total of 75 patients aged 65.3±12 years were included, of which 31 (41%) were males and 49 (65%) had positive serology for CD. Age, gender, diabetes, hypertension, ejection fraction, reason for PPM implantation and prior myocardial infarction were not significantly different between groups. After a 3-year follow up, 8 patients in the CD group and 1 in the control group died. Although mortality rate was higher in patients with CD seropositivity, the difference was not statistically significant (HR 3.86; p=0.17). Kaplan-Meier survival plot is illustrated bellow. Conclusions: CD was associated with a non-significant increased mortality rate in PPM patients. Larger prospective studies may reveal a significant prognostic role for CD seropositivity in this population.
<title>Quantitative Analysis Of Holograms And Specklegrams On A Hand Held Calculator</title> (1983)

Recent advances in laser metrology, based on the concept of projection matrices have to led to the development of a new method for quantitative analysis of holograms and specklegrams. Using this method, all necessary calculations can be carried out, in an interactive manner, on a hand held calculator. In this study, the HP4lC System was used, however, the existing programs can be modified to accomodate other hand held calculators. The parameters required to solve the governing equations of this method are determined directly from multiple observations of holograms, or specklegrams. The results, based on these parameters, provide complete three-dimmensional information on object&apos;s translations and rotations, including compensation for rigid-body motions, if necessary, as well as the information on object&apos;s deformations. The accuracy of the results obtained in these analysis will be discussed. Representative examples on the use of this method in engineering applications, will be presented.
miR ‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis* (2022)

Collectively, our findings identify miR-378a as an amplifier of IL-17A-induced NF-κB signalling in keratinocytes and suggest that increased miR-378a levels contribute to the amplification of IL-17A-driven skin inflammation in psoriasis.
EFFECT OF DIFFERENT MOLLUSC ASSOCIATIONS ON TARGET MOLLUSC GROWTH AND PARASITE CERCARIAL PRODUCTION IN THE TRIPLE SYSTEM: BULINUS WRIGHTI-SCHISTOSOMA BOVIS AND MELANOPSIS PRAEMORSA (1992)

The influence of different mollusc associations in the triple system: Bulinus wrighti (target mollusc: TM)—Schistosoma bovis (parasite)—Melanopsis praemorsa (non-target mollusc: NTM) is analysed. The results show that: (i) for a TM/NTM density ratio of 1/1, the NTM stimulates both growth of the TM and parasite cercarial production; (ii) for a TM/NTM density ratio of 1/5, the effects of the NTM on TM growth and cercarial production were not additive and were less marked than for the 1/1 ratio. Hypotheses on a chemical explanation for these density-dependent effects are discussed.
The use of HPLC-pulsed amperometry for the characterization and assay of glycosidases and glycosyltransferases (1991)

A sensitive and reproducible high performance chromatographic procedure is described for the assay of jack bean beta-galactosidase in which the reaction products are separated on a Dionex AS6 ion exchange column under alkaline conditions and detected by triple-pulsed amperometry. Quantition of the enzyme-released galactose is accomplished by using either fucose or lactose, the substrate, as an internal standard. The validity of the procedure as a general method for the assay and kinetic characterization of exoglycosidases was demonstrated by performing parallel measurements of galactose using an established coupled-enzyme assay, and using these values to calculate Km and Vmax values against lactose. Additional data are presented which establish the applicability of using a similar HPLC approach for the assay of glycosyltransferases.
A Novel Gene Marker for Colon Cancer. (1998)

近年,上皮細胞で特異的に発現する遺伝子のRT-PCRを利用して体液やリンパ節中に存在する微量の癌細胞を検出し,癌の進行度評価や治療方針の選択に応用する試みが報告'されている.しかしながら現在まで報告されているマーカーのほとんどはその組織特異性に問題があり,実際の臨床応用は困難である.われわれはヒトゲノムプロジェクトの一環として作製されている3'directed cDNA libraryを用いて,大腸組織特異的な発現を示す候補遺伝子マーカーのスクリーニングを行い,その臨床応用を検討している.まず正常大腸粘膜から作製した3'directed cDNA libraryと他のlibraryの発現profileの比較を行い,次いで種々の組織のRNAを用いたRT-PCRから最終的にgs04094が特異的遺伝子マーカーとして選択された.gs04094は胃,小腸,大腸などの消化管上皮で発現し,正常リンパ節,肝,腹膜,脂肪組織,皮膚などでの発現は全く認めなかった.大腸癌組織のRNAを正常リンパ節のRNAで希釈して行った実験から,その検出感度は10と算定された.また上流のcoding regionのcDNAクローニングを行った結果,このgs04094はchloride channelをコードする遺伝子であることが判明した.RT-PCR法を用いた癌の微小転移診断においてはその発現特異性が最も重要な問題であるが,3'directed cDNA libraryは組織特異的遺伝子マーカーの検索に有用であると考えられた.
Excessive Gestational Weight Gain in Women with Gestational and Pregestational Diabetes (2011)

We sought to determine the frequency of excessive gestational weight gain (GWG) and its impact on perinatal outcomes in women with gestational (GDM) and pregestational diabetes mellitus (DM). A retrospective cohort of diabetic women was studied. GWG was categorized by the 2009 Institute of Medicine guidelines. Perinatal outcomes were compared between those women with and without excessive GWG. There were 153 women who met study criteria. There was no difference in excessive GWG between women with GDM and pregestational DM (44.4% versus 38.5%, P = 0.51) or based on White's class ( P = 0.17). After adjusting for confounders, excessive GWG was not associated with an increased rate of adverse perinatal outcomes (odds ratio 1.49, 95% confidence interval 0.56 to 2.35) and had similar associations with both pregestational DM and GDM. Although excessive GWG was common in our diabetic population, it was not associated with an increased rate of adverse perinatal outcomes.
A Phase II Dose Escalation Study of Intraarterial (Hepatic) Adult Human Bone Marrow Derived, Cultured, Pooled, Allogeneic Mesenchymal Stromal Cells (Stempeucel®) in Patients with Alcoholic Liver Cirrhosis (2021)

Background: Alcoholic liver cirrhosis is an end-stage alcoholic liver disease with a poor prognosis. The definitive treatment of alcoholic liver cirrhosis is orthotopic liver transplantation, which is expensive, requires long-term immunosuppression and is limited by the supply of organs. Being an unmet medical need, cell therapy is under investigation for alcoholic liver cirrhosis. Aims: This study was designed primarily for assessing the safety and feasibility of administering stempeucel® through the hepatic artery in alcoholic liver cirrhosis and secondarily to assess possible efficacy and dose-response. Methods: Sixty patients with alcoholic cirrhosis (18-65 years/Child-Pugh class B or C/Model for End-Stage Liver Disease score of minimum 10) were planned to be included in 6 groups: 2.5 million cells/kg Body Weight (2.5M Cell) and respective control (2.5M Control); 5 million cells/kg Body Weight (5M Cell) and respective control (5M Control); 7.5 million cells/kg Body Weight (5M Cell) and respective control (7.5M Control) with 10 patients in each group. Cell groups received stempeucel® administered via hepatic artery by catheterization through the femoral artery (Seldinger technique) and Standard Protocol of Care. The control group received Standard Protocol of Care. Patients were followed up at 1 week, 1 month, 3 months and 6 months. Efficacy evaluations included liver function test, Model for End-Stage Liver Disease score, Child-Pugh score, Short Form-36 questionnaire, liver stiffness using Fibroscan (Transient Elastography), and liver volume using Computerized Tomography scan. Results: Stempeucel® injection was well tolerated. Common treatment-emergent adverse events were gastrointestinal disorders, general disorders and administration site conditions and infections and infestations. Most of the treatment-emergent adverse events were unrelated / remotely related to stempeucel®. Thirty serious adverse events occurred in 10 patients (3 in 2.5M Cell, 5 in 5M Cell and one each in control groups). Three patients died due to SAEs: Two in 2.5M and one in 5M Cell group, none were related to stempeucel®. Statistically significant improvement was seen in 2.5M group compared to the control group in Short Form-36 score: bodily pain, mental component summary, vitality and social functioning. Conclusion: Stempeucel® was safe, well-tolerated and subjective improvement in Short Form-36 (bodily pain, mental component summary, vitality and social functioning and mental health) score was seen in the 2.5M cell group.