gebhart/patrepeval huggingface dataset:
Electric Drives (2009)

No AccessPlastics Manufacturing Systems EngineeringJun 2009Electric DrivesDavid O. KazmerDavid O. KazmerSearch for more papers by this authorhttps://doi.org/10.3139/9783446430143.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2009Pages: 125-156Print ISBN: 978-3-446-42014-4eISBN: 978-3-446-43014-3 Copyright & Permissions© 2009 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Design, synthesis, in vivo and in silico anticonvulsant activity studies of derivatives of 6-amino-4-hydroxy-2-thio-pyrimidine (2020)

The aim of the given research was the targeted synthesis of anticonvulsants -(4-amino-6-hydroxy-pyrimidin-2-yl)thio-N-acetamides derivatives. Perspective of the search of anticonvulsants was evaluated by the ADMET method and docking study. The starting 6-amino-2-thiopyrimidine was obtained in result of reaction between thiourea and ethyl cyanoacetate in sodium ethoxide environment. The targeted thioacetamide derivatives were synthesized by alkylation of 6-amino-2-thiopyrimidine with the corresponding 2-chloroacetamides in DMFA environment in potassium carbonate presence. The structure of the synthesized compounds was determined using 1 H and 13 C NMR spectroscopy, LS/MS, and elemental analysis. A screening study of anticonvulsant activity on the model of pentylenetetrazole-induced seizures in rats was carried out. A lead compound -2-((4-amino-6-hydroxypyrimidin-2-yl)thio)-N-(3-methylphenyl)acetamide -was found. The mentioned compound has shown its ability to prevented lethality, reduce the number and severity of seizures, as well as to increase latency period. Some correlation features between structure and anticonvulsant activity were determined. The obtained results of molecular docking study have shown the affinity of the lead compound to GABA A , GABA AT , Carbonic Anhydrase II, and NMDA receptors, and a possible mechanism for anticonvulsant action.
The effect of oxygen partial pressure during heat treatment on the microstructure of dip-coated Bi-2212/Ag and Ag alloy tapes (1997)

The evolution of the microstructure during heat treatment was investigated for dip-coated Bi/sub 2/Sr/sub 2/CaCu/sub 2/O/sub y/(Bi-2212)/Ag and Ag alloy tapes as a function of temperature and oxygen partial pressure (P(O/sub 2/)=0.01, 0.21 and 1 atm) using quenched and fully-processed tapes. The microstructures were essentially the same for Bi-2212 on pure Ag and on the Ag alloy, Although the melting temperature of Bi-2212 increased with increasing P(O/sub 2/), the solidification temperature (T/sub sol/) of Bi-2212 for P(O/sub 2/)=0.21 atm was higher than that for P(O/sub 2/)=1 atm. The volume fraction and grain alignment of Bi-2212 processed in P(O/sub 2/)=0.01 atm was smaller than in tapes processed in 0.21 and 1 atm, which were quite similar. HR-TEM studies on grain boundaries and AC susceptibility measurements suggest that the higher critical current density(J/sub c/) for tapes processed in P(O/sub 2/)=1 atm than that for 0.21 atm is due to improved coupling of the grains.
Prediction of Sustained Response After Nucleo(s)tide Analogue Cessation Using HBsAg and HBcrAg Levels: A Multicenter Study (CREATE) (2020)

In this multicenter study, off-treatment outcomes after NA cessation varied with ethnicity. Lower levels of HBcrAg and HBsAg were associated with favorable outcomes. A risk score comprising both factors can be used for risk stratification.
Shot Noise in Self-Stabilized Optical Frequency Combs (2019)

We stabilized the repetition rate of an optical frequency comb with a fiber-optic interferometer and used the stabilized comb to generate a low-phase-noise 10-GHz signal. We demonstrated that shot noise limited the previously reported phase noise of the device. We mitigated this noise to generate a 10-GHz signal with phase noise of-130 dBc/Hz at an offset of 1 kHz.
Novel Electrostatically Doped Planar Field-Effect Transistor for High Temperature Applications (2014)

In this paper, we investigate by simulation and by evaluation of experimental data the feasibility of an electrostatically doped and therefore voltage-programmable, planar, CMOS-compatible field-effect-transistor (FET) structure which is based on our already published Si-nanowire (SiNW) technology. The key technology for this dual-gated general purpose FET contains Schottky S/D junctions on a silicon-on-insulator (SOI) platform. In combination with electrostatic doping and a dual-gate configuration, the Schottky junctions significantly increase the temperature robustness of the device.
Probing the 14-3-3 Isoform-Specificity Profile of Interactions Stabilized by Fusicoccin A (2020)

Fusicoccin A (FC) is a fungal phytotoxin that stabilizes protein–protein interactions (PPIs) between 14-3-3 adapter proteins and their phosphoprotein interaction partners. In recent years, FC has emerged as an important chemical probe of human 14-3-3 PPIs implicated in cancer and neurological diseases. These previous studies have established the structural requirements for FC-induced stabilization of 14-3-3·client phosphoprotein complexes; however, the effect of different 14-3-3 isoforms on FC activity has not been systematically explored. This is a relevant question for the continued development of FC variants because there are seven distinct isoforms of 14-3-3 in humans. Despite their remarkable sequence and structural similarities, a growing body of experimental evidence supports both tissue-specific expression of 14-3-3 isoforms and isoform-specific functions in vivo. Herein, we report the isoform-specificity profile of FC in vitrousing recombinant human 14-3-3 isoforms and a focused library of fluorescein-labeled hexaphosphopeptides mimicking the C-terminal 14-3-3 recognition domains of client phosphoproteins targeted by FC in cell culture. Our results reveal modest isoform preferences for individual client phospholigands and demonstrate that FC differentially stabilizes PPIs involving 14-3-3s. Together, these data provide strong motivation for the development of non-natural FC variants with enhanced selectivity for individual 14-3-3 isoforms.
ChemInform Abstract: Effect of R3+ Ions on the Structure and Properties of Lanthanum Borate Glasses. (1986)

Abstract Glass formation in the Systems (I) and (II) has been investigated.
Holodeck: Immersive 3D Displays Using Swarms of Flying Light Specks (2021)

Unmanned Aerial Vehicles (UAVs) have moved beyond a platform for hobbyists to enable environmental monitoring, journalism, film industry, search and rescue, package delivery, and entertainment. This paper describes 3D displays using swarms of flying light specks, FLSs. An FLS is a small (hundreds of micrometers in size) UAV with one or more light sources to generate different colors and textures with adjustable brightness. A synchronized swarm of FLSs renders an illumination in a pre-specified 3D volume, an FLS display. An FLS display provides true depth, enabling a user to perceive a scene more completely by analyzing its illumination from different angles. An FLS display may either be non-immersive or immersive. Both will support 3D acoustics. Non-immersive FLS displays may be the size of a 1980's computer monitor, enabling a surgical team to observe and control micro robots performing heart surgery inside a patient's body. Immersive FLS displays may be the size of a room, enabling users to interact with objects, e.g., a rock, a teapot. An object with behavior will be constructed using FLS-matters. FLS-matter will enable a user to touch and manipulate an object, e.g., a user may pick up a teapot or throw a rock. An immersive and interactive FLS display will approximate Star Trek's Holodeck. A successful realization of the research ideas presented in this paper will provide fundamental insights into implementing a Holodeck using swarms of FLSs. A Holodeck will transform the future of human communication and perception, and how we interact with information and data. It will revolutionize the future of how we work, learn, play and entertain, receive medical care, and socialize.
Interferon Reduces the Risk of Hepatocellular Carcinoma in Hepatitis C Virus-Related Chronic Hepatitis/Liver Cirrhosis (2010)

The efficacy of interferon therapy against hepatitis C virus (HCV) has much improved, showing a sustained virologic response rate of 40-50% even in the genotype 1b with a high viral load. Several cohort studies conducted in Japan in the 1990s unanimously concluded that the risk of hepatocellular carcinoma (HCC) development was reduced in patients who achieved a sustained virologic response or persistent normalization of alanine aminotransferase as compared to untreated patients. Recently, a large-scale randomized controlled trial, called the HALT-C study, showed no significant difference in the incidence of HCC between patients on maintenance interferon therapy and those without. The reason for the discrepant results in Japanese and USA studies needs further clarification, together with analysis of the difference in incidence rates of HCC among cirrhotic patients. There has also been progress in the treatment of HCC, and together with advances in diagnostics facilitating HCC detection at an early stage, tumor nodules can often be completely removed either by medical ablation or surgical resection. Nevertheless, recurrence of HCC after apparently curative treatment is extraordinarily frequent, since the remaining liver is still at a high risk of HCC. The prevention of the recurrence of HCC, or tertiary prevention, is currently one of the most challenging tasks in hepatology.
Can a single‐shot black‐blood T2‐weighted spin‐echo echo‐planar imaging sequence with sensitivity encoding replace the respiratory‐triggered turbo spin‐echo sequence for the liver? an optimization and feasibility study (2005)

Optimized SSBB-EPI with SENSE proved to be feasible in patients, and the overall image quality and SNR of the liver were comparable to those achieved with the standard respiratory-triggered T2-weighted TSE sequence.
From Data Processing to Multivariate Validation - Essential Steps in Extracting Interpretable Information from Metabolomics Data (2011)

In metabolomics studies there is a clear increase of data. This indicates the necessity of both having a battery of suitable analysis methods and validation procedures able to handle large amounts of data. In this review, an overview of the metabolomics data processing pipeline is presented. A selection of recently developed and most cited data processing methods is discussed. In addition, commonly used chemometric and machine learning analysis methods as well as validation approaches are described.
Thermal Maturation and Petroleum Source Rocks in Forest City and Salina Basins, Mid-Continent, U.S.A.: ABSTRACT (1986)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Accuracy of Magnetic Resonance Imaging/Ultrasound Fusion Targeted Biopsies to Diagnose Clinically Significant Prostate Cancer in Enlarged Compared to Smaller Prostates (2015)

Magnetic resonance imaging-transrectal ultrasound fusion biopsies increased the yield of first round prostate biopsies in patients with a prostate volume greater than 40 cm(3).
Angiogenesis: A link to Thrombosis in Athero-thrombotic Disease (2003)

New insights to explain the clinical manifestations of atherosclerosis have resulted in a paradigm in which thrombosis is the major cause of acute coronary syndromes, peripheral arterio-vascular disease and stroke. Major efforts have been directed toward developing drugs to reduce thrombin and fibrin formation. Recent studies support a central role for angiogenesis of the atherosclerotic plaque in promoting atherothrombosis. The findings, in the face of efforts to use angiogenic agents to enhance vascular function, underline the challenge in treating atherothrombotic disease.
High-resolution imaging of ultracold fermions in microscopically tailored optical potentials (2011)

We report on the local probing and preparation of an ultracold Fermi gas on the length scale of one micrometer, i.e. of the order of the Fermi wavelength. The essential tool of our experimental setup is a pair of identical, high-resolution microscope objectives. One of the microscope objectives allows local imaging of the trapped Fermi gas of 6Li atoms with a maximum resolution of 660 nm, while the other enables the generation of arbitrary optical dipole potentials on the same length scale. Employing a two-dimensional (2D) acousto-optical deflector, we demonstrate the formation of several trapping geometries, including a tightly focused single optical dipole trap, a 4×4 site 2D optical lattice and an 8 site ring lattice configuration. Furthermore, we show the ability to load and detect a small number of atoms in these trapping potentials. A site separation down to one micrometer in combination with the low mass of 6Li results in tunneling rates that are sufficiently large for the implementation of Hubbard models with the designed geometries.
Amorphous and Cellular Computing (2001)

Problem:The objective of this work is to create a new engineering discipline for reliably obtaining useful, prespecified behavior from vast numbers of asynchronous, irregularly arranged information-processing units that communicate with only a few neighbors.Progress in microfabrication and in bioengineering will make it possible to assemble such amorphous systems at almost no cost, provided that 1) the units need not all work correctly; 2) the units are identically programmed; and 3) there is no need to manufacture precise geometrical arrangements of the units or precise interconnections among them.Harnessing these systems for information processing and intelligent materials requires augmenting traditional information processing with new perspectives and techniques from biology.
Strength and fracture toughness of spray formed Al–Cu–Mg–Ag alloys (1999)

Spray formed Al–4·5Cu–Mg–Ag alloys with small additions of titanium, zirconium, and manganese show improved mechanical properties compared with conventionally produced alloys of the same class. In particular, the combination of strength, fracture toughness, and microstructural stability at elevated temperature is clearly superior. At room temperature, typical yield strength values of over 420 MPa, elongations to fracture of 13%, and fracture toughness values of 75–85 MPa m1/2 in the peak aged condition have been measured. Good thermal stability up to 453 K (180°C) can be achieved by limiting the magnesium content to values below 0·4 wt-%. Compared to the commercial heat resistant alloy 2618-T61, spray formed Al–Cu–Mg–Ag alloys offer higher strength after 1000 h exposure to temperatures up to 423 K (150°C). In addition, they clearly exceed 2618-T61 in terms of fracture toughness. The high yield strength is mainly attributed to fine and densely distributed precipitates of Ω and Θ′ phases, and the fine unrecrystallised grain structure. This structure is stabilised by a fine distribution of zirconium containing dispersoids. An additional contribution to strength can be given by cold work before artificial aging. The fracture toughness can be improved by limiting the content of coarse copper and zirconium containing constituents. This is achieved by control of chemical composition and processing.
Polarizability of a Two-Dimensional Electron Gas (1967)

The response of a two-dimensional electron gas to a longitudinal electric field of arbitrary wave vector and frequency is calculated in the self-consistent-field approximation. The results are used to find the asymptotic screened Coulomb potential and the plasmon dispersion for a plane of electrons imbedded in a three-dimensional dielectric.
Mass Balance Study of the Engineered Cationic Antimicrobial Peptide, WLBU2, Following a Single Intravenous Dose of 14C-WLBU2 in Mice (2020)

WLBU2 distributes widely to mouse tissues and is rapidly cleared with a terminal radioactivity half-life of 22 h, a clearance of 27.4 mL/h/kg, and a distribution volume of 0.94 L/kg. At 2-100 μg-eq/g, the concentrations of 14C-WLBU2 appear high enough in the tissues to account for the inhibition of microbial growth.
Efficient switching of mCherry fluorescence using chemical caging (2017)

Fluorophores with dynamic or controllable fluorescence emission have become essential tools for advanced imaging, such as superresolution imaging. These applications have driven the continuing development of photoactivatable or photoconvertible labels, including genetically encoded fluorescent proteins. These new probes work well but require the introduction of new labels that may interfere with the proper functioning of existing constructs and therefore require extensive functional characterization. In this work we show that the widely used red fluorescent protein mCherry can be brought to a purely chemically induced blue-fluorescent state by incubation with β-mercaptoethanol (βME). The molecules can be recovered to the red fluorescent state by washing out the βME or through irradiation with violet light, with up to 80% total recovery. We show that this can be used to perform single-molecule localization microscopy (SMLM) on cells expressing mCherry, which renders this approach applicable to a very wide range of existing constructs. We performed a detailed investigation of the mechanism underlying these dynamics, using X-ray crystallography, NMR spectroscopy, and ab initio quantum-mechanical calculations. We find that the βME-induced fluorescence quenching of mCherry occurs both via the direct addition of βME to the chromophore and through βME-mediated reduction of the chromophore. These results not only offer a strategy to expand SMLM imaging to a broad range of available biological models, but also present unique insights into the chemistry and functioning of a highly important class of fluorophores.
Stevia rebaudiana Bertoni extract supplementation improves lipid and carnitine profiles in C57BL/6J mice fed a high‐fat diet (2010)

These results suggest that the supplementation of stevia extract might have an anti-obesity effect on high-fat diet induced obese mice.
Evaluation of new molecules against jassids and white flies of Bt cotton (2017)

An experiment was conducted to evaluate the efficacy of new molecules as well as biopesticides against jassids and whiteflies of Bt cotton. Ten treatments i.e. Buperofezin 25 SC@250ml a.i.ha-1, flonicamid 50 WG (75 & 100g a.i.ha-1), fipronil 5 SC (100 & 87.5ml a.iha-1), diafenthiuron 50 WP @300g a.i. ha-1, NSKE 5%, Verticillium lacanii @ 10g lit.-1, Metarhizium anisopliae @ 10g lit-1 and check were evaluated. Seven days after spray, the maximum per cent reduction in jassids and whitefly population with a mean of 77.80; 79.13 and 81.71; 83.27 was recorded in difenthiuron 50 WP during both the years, respectively and it was statistically at par with flonicamid 50 WP@ 100g a.i. and fipronil 5 EC @ 100g a.i.ha-1. Among biopesicides, NSKE 5% gave comparatively higher per cent reduction in population of jassids and whiteflies in compare to entomopathogenic fungals. The maximum mean seed cotton yield of 3101 kgha-1 with highest net profit of Rs. 51,381 ha-1 was obtained in difenthiuron 50 WP @ 300g a.i ha-1.
SAR prescreening using both target and shadow information (2002)

The utility of fusing shadow and intensity detections in a SAR prescreener is evaluated over the MSTAR database. We use either power ratio, GLRT or two-parameter CFAR tests to extract the two detections. For any testing strategy, the addition of shadow information improves performance.
Single domain antibodies as new detectors of neurotoxic Aβ42 oligomers (2023)

Abstract Background The presence of extracellular amyloid β (Aβ) plaques in the brain parenchyma and intracellular neurofibrillary tangles of the hyperphosphorylated tau protein is the main hallmark of Alzheimer’s disease (AD). Aβ aggregation consists of a complex chain of nucleation events producing soluble oligomer intermediates, which are the major neurotoxic agents. The transient nature of these oligomers makes very challenge their isolation and characterization. Single domain Abs (sdAbs), composed only of a variable domain of the heavy chain with high specificity and affinity, appear as promising tools for an early accurate diagnosis and therapy for AD. Method An in vitro and in vivo screening of different sdAbs was performed, selecting those targeting Aβ 42 oligomers with high specificity using immunoassays and the super resolution stimulated emission depletion (STED) microscopy. The ability of sdAbs to prevent Aβ 42 ‐induced cytotoxicity in neuronal cells was investigated. Then, the sdAbs were used to detect and quantify the levels of Aβ 42 assemblies in the cerebrospinal fluid (CSF) of AD patients and controls. Result SdAbs can detect neurotoxic Aβ assemblies and prevent the associated neuronal dysfunction in cell models. Furthermore, sdAbs significantly discriminated Aβ aggregates in the CSF. Conclusion All these data provide solid grounds for the understanding of the molecular basis of oligomers toxicity, thus establishing a compelling structure‐toxicity relationship. Moreover, sdAbs‐based approaches hold a great potential as they allow detection in complex mixtures such as a biological sample for an early differential diagnosis of AD, also providing therapeutic benefits. The study was supported by Airalzh (AGYR 2020 to R.C.).
Multimodal Neuroelectric Interface Development: A Survey of Research at NASA Ames Research Center (2002)

We are developing electromyographic (EMG) and electroencephalographic (EEG) methods that bypass muscle activity and draw control signals for human-computer interfaces directly from the human nervous system. We have made progress in four areas: a) real-time pattern recognition algorithms for decoding sequences of forearm muscle activity associated with control gestures, b) signal-processing strategies for computer interfaces using EEG signals, c) a flexible computation framework for neuroelectric interface research, d) non-contact sensors, which measure EMG or EEG signals without resistive contact to the body. interfaces. We will describe an EMG-based flight stick, an EMG-based numeric keypad, an EEG-based interface for smooth, continuous control of a one dimension of motion in a graphic display, and comparison of algorithms for modeling the EEG patterns associated with real and imagined mouse motion or typing. Finally, we will present some new results on the development of non-contact electric field sensors for EMG and EEG recording. These sensors offer a less intrusive alternative to current sensing technology, which will make them more suitable for real-world applications. Our approach is to describe a body of developmental research, mostly still in progress, and to indicate methods that have potential for engineering development. Given the BCI focus of this special issue, descriptions of purely EMG-based interfaces will be brief. We will describe the EEG results and the new sensor developments in more detail.