gebhart/patrepeval huggingface dataset:
Ultra-high frequency magnetic resonance imaging (2007)

This thesis addresses the problem of radiofrequency probe design for Ultra High Frequency Magnetic Resonance Imaging (7T).\n\nThe signal-to-noise ratio available in Magnetic Resonance Imaging (MRI) is determined by the static magnetic field strength, causing a continued drive toward higher fields to enable faster image acquisition at finer spatial resolution. The resonant frequency increases linearly with static field strength. At 7T the proton resonant frequency is 300MHz, with a wavelength of approximately 13cm in tissue. As this is smaller than the dimensions of the human head, the phase of the radiofrequency (RF) signal varies considerably across the sample, producing field cancellation due to interference.\n\nA full wave electromagnetic simulator, using the Transmission Line Matrix (TLM) method, was developed to investigate RF probes at high frequency. A Birdcage probe operating at 64, 128 and 300MHz (corresponding to 1.5, 3 and 7T) was simulated, loaded with an anatomically detailed human head model. A half-wave microstrip was investigated for use as a high frequency probe element. Magnetic and electric fields produced by a single microstrip were simulated, and the strip dimensions varied to investigate the effect on field penetration into the head and Specific Absorption Rate (SAR). A transmit-receive array probe using four microstrip elements was then developed.\n\nBloch simulations were run, using TLM generated magnetic fields, to investigate imaging at short wavelength. Parallel receive probes are demonstrated to offer considerable advantage over volume probes, as signals from receive elements can be combined without interference. There is no transmit equivalent to parallel reception; simultaneous excitation of independent probe elements causes interference in exactly the same manner as a volume probe. A new imaging sequence was developed using a Burst-like encoding to allow sequential excitation of probe elements, without interference, which can be recalled in a single readout. An improvement in image homogeneity was demonstrated, and SENSE acceleration of the new imaging sequence is shown.\n\nThe sequence was implemented at 3T using a purpose built four element microstrip probe. An RF multiplexer was also built to enable transmit element switching during the imaging sequence. It was demonstrated that images due to different RF excitations, acquired in a single EPI readout, can be separated.
Long-Term Bonding and Tensile Strengths of Carbon Textile Reinforced Mortar (2020)

This paper deals with the long-term bonding and tensile strengths of textile reinforced mortar (TRM) exposed to harsh environments. The objective of this study was to investigate the long-term bonding and tensile strengths of carbon TRM by an accelerated aging method. Moisture, high temperature, and freezing-thaw cycles were considered to simulate harsh environmental conditions. Grid-type textiles were surface coated to improve the bond strength with the mortar matrix. A total of 130 TRM specimens for the bonding test were fabricated and conditioned for a prolonged time up to 180 days at varying moisture conditions and temperatures. The long-term bonding strength of TRM was evaluated by a series of bonding tests. On the other hand, a total of 96 TRM specimens were fabricated and conditioned at freezing-thaw conditions and elevated temperature. The long-term tensile strength of TRM was evaluated by a series of direct tensile tests. The results of the bonding test indicated that TRM was significantly degraded by moisture. On the other hand, the influence of the freezing-thaw conditions and high temperature on the tensile strength of the TRM was insignificant.
NUMERICAL SIMULATION OF THE COUPLED TENSION-SHEAR RESPONSE OF AN INNOVATIVE DISSIPATIVE CONNECTION FOR CLT BUILDINGS (2017)

NUMERICAL SIMULATION OF THE COUPLED TENSION-SHEAR RESPONSE OF AN INNOVATIVE DISSIPATIVE CONNECTION FOR CLT BUILDINGS - 6th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering Methods in Structural Dynamics and Earthquake Engineering - 15 - 17 June 2017, Rhodes Island, Greece
Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis (2008)

Some inherited periodic paralyses are caused by mutations in skeletal muscle Na(V)1.4 sodium channels that alter channel gating and impair action potential generation. In the case of hypokalemic periodic paralysis, mutations of one of the outermost two gating charges in the S4 voltage sensor in domain II of the Na(V)1.4 alpha subunit induce gating pore current, resulting in a leak of sodium or protons through the voltage sensor that causes depolarization, sodium overload, and contractile failure correlated with low serum potassium. Potassium-sensitive normokalemic periodic paralysis (NormoPP) is caused by mutations in the third gating charge in domain II of the Na(V)1.4 channel. Here, we report that these mutations in rat Na(V)1.4 (R669Q/G/W) cause gating pore current that is activated by depolarization and therefore is conducted in the activated state of the voltage sensor. In addition, we find that this gating pore current is retained in the slow-inactivated state and is deactivated only at hyperpolarized membrane potentials. Gating pore current through the mutant voltage sensor of slow-inactivated NormoPP channels would cause increased sodium influx at the resting membrane potential and during trains of action potentials, depolarize muscle fibers, and lead to contractile failure and cellular pathology in NormoPP.
A bumblebee thioredoxin-like protein gene that is up-regulated by a temperature stimulus and lipopolysaccharide injection (2006)

A thioredoxin-like protein (txl) gene was cloned from the bumblebee, Bombus ignitus. The B. ignitus txl (Bitxl) gene spans 1777 bp and consists of three introns and four exons coding for 285 amino acid residues with a conserved active site (CGPC). The deduced amino acid sequence of the Bitxl cDNA was 65% similar to the Drosophila melanogaster txl. Northern blot analysis revealed the presence of Bitxl transcripts in all tissues examined. When H2O2 was injected into the body cavity of B. ignitus workers, Bitxl mRNA expression was up-regulated in the fat body tissue. In addition, the expression levels of Bitxl mRNA in the fat body greatly increased when B. ignitus workers were exposed to low (4Â°C) or high (37Â°C) temperatures, or injected with lipopolysaccharide (LPS), which suggests that the Bitxl possibly protects against oxidative stress caused by extreme temperatures and bacterial infection.
Synthesis of dicyclopenta[ef,kl]heptalene (azupyrene). I. Routes to 1,6,7,8,9,9a-hexahydro-2H-benzo[c,d]azulen-6-one (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of dicyclopenta[ef,kl]heptalene (azupyrene). I. Routes to 1,6,7,8,9,9a-hexahydro-2H-benzo[c,d]azulen-6-oneArthur G. Anderson Jr., Gary M. Masada, and Andrew F. MontanaCite this: J. Org. Chem. 1973, 38, 8, 1439–1444Publication Date (Print):April 1, 1973Publication History Published online1 May 2002Published inissue 1 April 1973https://pubs.acs.org/doi/10.1021/jo00948a001https://doi.org/10.1021/jo00948a001research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sub 1pJ/bit dense optical interconnects using microLEDs on CMOS transceiver ICs (2023)

We demonstrate low energy optical interconnects (0.6pJ/bit at 1E-4 error rate and 1.3pJ at 1E-12) using a custom 32-channel microLED-based optical link with monolithically integrated drivers, photodetectors, and TIAs. Each channel is modulated at 2Gb/s and the signal is carried either via multicore fiber or through free space.
APOL1 Oligomerization as the Key Mediator of Kidney Disease in African Americans (2015)

Abstract : The work we are conducting is aimed at understanding, and eventually preventing and treating, kidney disease, in particular the APOL1-associated form of kidney disease that accounts for the high rate of kidney disease in African Americans. This work is based on the hypothesis that APOL1 kidney disease in African Americans results from abnormal aggregation of the APOL1 risk variant protein in an amyloid-like process. We are testing this hypothesis in in vitro systems, cells, and model systems using molecular biology, biochemistry, protein chemistry, and microscopy-based approaches. In progress to date, we have elucidated key amino acids and functional domains in APOL1 protein that promote APOL1 oligomerization and cell cytotoxicity. We continue to refine our knowledge of APOL1-APOL1 interactions and the differences in these interactions between normal APOL1 and the variants that cause kidney disease. Our insights into the abnormal behavior of the high risk variants suggest potential therapies for APOL1 kidney disease including small molecules, peptide fragments, and other approaches.
Spatio-temporal dynamics of an encapsulated gas bubble in an ultrasound field (2006)

Coupled equations describing the radial and translational dynamics of an encapsulated gas bubble in an ultrasound field are derived by using the Lagrangian formalism. The equations generalize Church's theory by allowing for the translation motion of the bubble and radiation losses due to the compressibility of the surrounding liquid. The expression given by Church for the inner bubble radius corresponding to the unstrained state of the bubble shell is also refined, assuming that the shell can be of arbitrary thickness and impermeable to gas. Comparative linear analysis of the radial equation is carried out relative to Church's theory. It is shown that there are substantial departures from predictions of Church's theory. The proposed model is applied to evaluate radiation forces exerted on encapsulated bubbles and their translational displacements. It is shown that in the range of relatively high frequencies encapsulated bubbles are able to translate more efficiently than free bubbles of the equivalent size.
The Federation of Korean Industries Headquarters (2014)

The ultra-modern, 245-meter-tall Federation of Korean Industries (FKI) office tower is a significant and recent addition to the skyline of Seoul, South Korea. The building, including below-grade parking and support spaces, consists of 170,000 square meters of gross floor area with 111,000 square meters above grade. A separate, free-form, glass and steel rib-shell structure at the podium also houses a 6,000-square-meter conference center. The tower structural system consists of a reinforced concrete core and composite perimeter columns coupled with steel outriggers and belt trusses to resist lateral forces. The superstructure is founded on reinforced concrete bored piles socketed into the local rock formation. Five below-grade levels were constructed utilizing top-down construction techniques. The exterior wall of the tower has been furrowed as part of the architectural expression and to provide optimal utilization of building-integrated photovoltaic panels. The unique exterior skin is a key factor in disrupting the organization of wind vortices for the purely prismatic tower geometry. All documentation was produced in 3D REVIT and TEKLA models.
Modeling emission lag after photoexcitation (2017)

A theoretical model of delayed emission following photoexcitation from metals and semiconductors is given. Its numerical implementation is designed for beam optics codes used to model photocathodes in rf photoinjectors. The model extends the Moments approach for predicting photocurrent and mean transverse energy as moments of an emitted electron distribution by incorporating time of flight and scattering events that result in emission delay on a sub-picosecond level. The model accounts for a dynamic surface extraction field and changes in the energy distribution and time of emission as a consequence of the laser penetration depth and multiple scattering events during transport. Usage in the Particle-in-Cell code MICHELLE to predict the bunch shape and duration with or without laser jitter is given. The consequences of delayed emission effects for ultra-short pulses are discussed.
Metabolomics in paediatric oncology: a potential still to be exploited (2013)

Oncology is a branch of medicine in rapid evolution in the attempt to find innovative methods for early diagnosis and a better understanding of tumoral processes leading to the development of new therapies. Metabolomics is the emerging discipline among the "omics" sciences which makes it possible to further expand our knowledge concerning cancer biology. Different studies have revealed the potential role of metabolomics in gaining an understanding of pathophysiological processes in cancer, improving tumor staging, characterizing tumors and searching for biomarkers predictive of therapeutic responses. However, to date there are few works aimed at gaining deeper insights into infantile oncology through metabolomics.
New Weight Restrictions for Manure Hauling Equipment (2000)

Overview of updates for farm equipment weight restrictions. Includes weight restrictions with explanations.
Magnetically Driven Solid Sample Preparation for Centrifugal Microfluidic Devices (2009)

A prototype for solid sample preparation on centrifugal microfluidic devices has been designed and characterized. The system uses NdFeB magnets in both the centrifugal device and a fixed base. As the centrifugal device rotates, the magnets move and spin in their chambers creating a pulverizing mechanical motion. This technique was successfully applied to the dissolution of potassium ferricyanide (K(3)[Fe(CN)(6)]), a hard colored crystal. A 0.10 g sample was completely dissolved in 3 s in 1.0 mL of water while rotating at 1000 rpm. This is a 300-fold improvement over static dissolution.
Rapid and Sensitive Determination of Lipid Oxidation Using the Reagent Kit Based on Spectrophotometry (FOODLABfatSystem) (2016)

The reliability and availability of FOODLAB fat system for determining acid value (AV) and peroxide value (POV) were assessed during the hydrolytic rancidification and lipid oxidation of edible oils. This reagent kit based on spectrophotometry was compared to the official methods (ISO 660 and 3960 protocols) based on manual titration employing the standard mixture for the simulated oxidation models and edible oils during the thermally induced oxidation at 180°C. The linear regression line of standard mixture and the significant difference of thermally oxidized time course study determined between them showed high correlations (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:msup><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn mathvariant="normal">0.998</mml:mn></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>) in both AVs and POVs. Considering ISO protocols with a probability of human error in manual titration, the rapidness and simplicity of the reagent kit based on spectrophotometry make it a promising alternative to monitor the lipid oxidation of edible oils and lipid-containing foods.
Human Fetal Exposure to Triclosan and Triclocarban in an Urban Population from Brooklyn, New York (2014)

Triclosan (TCS) and triclocarban (TCC) are antimicrobial agents formulated in a wide variety of consumer products (including soaps, toothpaste, medical devices, plastics, and fabrics) that are regulated by the U.S. Food and Drug Administration (FDA) and U.S. Environmental Protection Agency. In late 2014, the FDA will consider regulating the use of both chemicals, which are under scrutiny regarding lack of effectiveness, potential for endocrine disruption, and potential contribution to bacterial resistance to antibiotics. Here, we report on body burdens of TCS and TCC resulting from real-world exposures during pregnancy. Using liquid chromatography tandem mass spectrometry, we determined the concentrations of TCS, TCC, and its human metabolites (2'-hydroxy-TCC and 3'-hydroxy-TCC) as well as the manufacturing byproduct (3'-chloro-TCC) as total concentrations (Σ-) after conjugate hydrolysis in maternal urine and cord blood plasma from a cohort of 181 expecting mother/infant pairs in an urban multiethnic population from Brooklyn, NY recruited in 2007-09. TCS was detected in 100% of urine and 51% of cord blood samples after conjugate hydrolysis. The interquartile range (IQR) of detected TCS concentrations in urine was highly similar to the IQR reported previously for the age-matched population of the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2004, but typically higher than the IQR reported previously for the general population (detection frequency = 74.6%). Urinary levels of TCC are reported here for the first time from real-world exposures during pregnancy, showing a median concentration of 0.21 μg/L. Urinary concentrations of TCC correlated well with its phase-I metabolite ∑-2'-hydroxy-TCC (r = 0.49) and the manufacturing byproduct ∑-3'-chloro-TCC C (r = 0.79), and ∑-2'-hydroxy-TCC correlated strongly with ∑-3'-hydroxy-TCC (r = 0.99). This human biomonitoring study presents the first body burden data for TCC from exposures occurring during pregnancy and provides additional data on composite exposure to TCS (i.e., from both consumer-product use and environmental sources) in the maternal-fetal unit for an urban population in the United States.
Internationalization Of Higher Education In The Light Of Some Indicators (2016)

At all the conferences held by the actors involved in the provision of Higher Education internationalization is seen as a new and indispensable dimension which must be considered within the mission of Higher Education Institutions (HEIs). Several reasons, of national as well as international nature, support this recommendation. Among the first ones, the development of human resources; the creation of strategic alliances; the generation of income/commerce and transactions; the construction of Nation and institutions; social and cultural development; and mutual understanding are worth mentioning. Whereas the enhancement of the international image and reputation; quality improvement; human resources development; income generation; the creation of strategic alliances; research and knowledge production are among the institutional reasons that lead to the internationalization of HEIs (Knight, 2005). Likewise there are several different higher education internationalization modalities that may be adopted by a HEI such as students and teachers mobility; distant education or education delivered by institutions located abroad; the design and strengthening of strategies and programs which are oriented to regional integration and international cooperation; formation of nets and projects for international cooperation and the celebration of inter institutional alliances, and the incorporation of the international dimension in the study programs. This presentation intends to assess the degree of internationalization of three Argentine HEIs by means of a group of indicators.
Resistant starch improves insulin sensitivity in metabolic syndrome (2010)

Consumption of resistant starch improves insulin sensitivity in subjects with the metabolic syndrome. Unlike in animal models, diabetes prevention does not appear to be directly related to changes in body adiposity, blood lipids or inflammatory markers. Further research to elucidate the mechanisms behind this change in insulin sensitivity in human subjects is required.
Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2′-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR (2023)

Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are "stop" mutations that generate a premature termination codon (PTC), thus synthesizing a truncated CFTR protein. A way to bypass PTC relies on ribosome readthrough, which is the ribosome's capacity to skip a PTC, thus generating a full-length protein. "TRIDs" are molecules exerting ribosome readthrough; for some, the mechanism of action is still under debate. We investigate a possible mechanism of action (MOA) by which our recently synthesized TRIDs, namely NV848, NV914, and NV930, could exert their readthrough activity by in silico analysis and in vitro studies. Our results suggest a likely inhibition of FTSJ1, a tryptophan tRNA-specific 2'-O-methyltransferase.
Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells (2011)

Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117. SCF-Kit signalling is crucial for the survival, proliferation and differentiation of hematopoietic cells of myeloid lineage. Furthermore, since myeloid leukaemia cells express the Kit receptor, SCF may play an important role in myeloid leukaemia progression too. However, the mechanisms of this pathophysiological effect remain unclear. Recent evidence shows that SCF triggers accumulation of the inducible alpha subunit of hypoxia-inducible factor 1 (HIF-1) in hematopoietic cells--a transcription complex that plays a pivotal role in cellular adaptation to low oxygen availability. However, it is unknown how SCF impacts on HIF-1α accumulation in human myeloid leukaemia and mast cells. Here we show that SCF induces HIF-1α accumulation in THP-1 human myeloid leukaemia cells but not in LAD2 mast cells. We demonstrated that LAD2 cells have a more robust glutathione (GSH)-dependent antioxidative system compared to THP-1 cells and are therefore protected against the actions of ROS generated in an SCF-dependent manner. BSO-induced GSH depletion led to a significant decrease in HIF-1α prolyl hydroxylase (PHD) activity in THP-1 cells and to near attenuation of it in LAD2 cells. In THP-1 cells, SCF-induced HIF-1α accumulation is controlled via ERK, PI3 kinase/PKC-δ/mTOR-dependent and to a certain extent by redox-dependent mechanisms. These results demonstrate for the first time an important cross-talk of signalling pathways associated with HIF-1 activation--an important stage of the myeloid leukaemia cell life cycle.