gebhart/patrepeval huggingface dataset:
Dimerization with Retinoid X Receptors Promotes Nuclear Localization and Subnuclear Targeting of Vitamin D Receptors (2000)

The vitamin D receptor (VDR) acts as heterodimer with the retinoid X receptor alpha (RXR) to control transcriptional activity of target genes. To explore the influence of heterodimerization on the subcellular distribution of these receptors in living cells, we developed a series of fluorescent-protein chimeras. The steady-state distribution of the yellow fluorescent protein-RXR was more nuclear than the unliganded green fluorescent protein (GFP)-VDR. Coexpression of RXR-blue fluorescent protein (BFP) promoted nuclear accumulation of GFP-VDR by influencing both nuclear import and retention. Fluorescence resonance energy transfer microscopy (FRET) demonstrated that the unliganded GFP-VDR and RXR-BFP form heterodimers. The increase in nuclear heterodimer content correlated with an increase in basal transcriptional activity. FRET also revealed that calcitriol induces formation of multiple nuclear foci of heterodimers. Mutational analysis showed a correlation between hormone-dependent nuclear VDR foci formation and DNA binding. RXR-BFP also promoted hormone-dependent nuclear accumulation and intranuclear foci formation of a nuclear localization signal mutant receptor (nlsGFP-VDR) and rescued its transcriptional activity. Heterodimerization mutant RXR failed to alter GFP-VDR and nlsGFP-VDR distribution or activity. These experiments suggest that RXR has a profound effect on VDR distribution. This effect of RXR to promote nuclear accumulation and intranuclear targeting contributes to the regulation of VDR activity and probably the activity of other heterodimerization partners.
Design of 400V class inverter drive using SiC 6-in-1 power module (2013)

SiC devices are considered to be the next generation power device. This paper discusses thedesign of a Variable Frequency Drive (VFD) using a 6-in-1 power module that employs SiC-DMOSFETs and SiC Schottky Barrier Diodes (SBDs). A 400V class 11kW prototype drive is designed using a 1200V/50A SiC module by Cree. In this paper, power losses of SiC 6-in-1 module are measured and results are compared with an IGBT-based VFD. Analysis shows that SiC drive does not require current derating up to 60 kHz of PWM switching frequency while standard IGBT drive needs significant derating. High dv/dt and voltage reflection effects are important when fast switching devices like SiC are used. This paper explains the design of an optimal output filter.
Advances in an active and passive targeting to tumor and adipose tissues (2014)

Unlike tumor tissues, only a few reports have appeared on how liposomal carriers accumulate in adipose tissues after systemic injection. This finding, as well as active targeting to the adipose vasculature, promises to extend the capacity of DDS to adipose tissue. Since the site of action of nucleic acids is the cytosol, the intracellular trafficking of carriers and their cargoes as well as cellular uptake must be taken into consideration.
Shear Mechanical Properties of Human Lumbar Annulus Fibrosus (2000)

Function, failure, and remodeling of the intervertebral disc are all related to the stress and strain fields in the tissue and may be calculated by finite element models with accurate material properties, realistic geometry, and appropriate boundary conditions. There is no comprehensive study in the literature investigating the shear material properties of the annulus fibrosus. This study obtained shear material properties of the annulus fibrosus and tested the hypothesis that these properties are affected by the amplitude and frequency of shearing, applied compressive stress, and degenerative state of the tissue. Cylindrical specimens with an axial orientation from seven nondegenerated and six degenerated discs were tested in torsional shear under dynamic and static conditions. Frequency sweep experiments over a physiological range of frequencies (0.1-100 rad/sec) at a shear strain amplitude of 0.05 rad were performed under three different axial compressive stresses (17.5, 25, and 35 kPa). At the largest compressive stress, shear strain sweep experiments (strain amplitude range: 0.005-0.15 rad at a frequency of 5 rad/sec) and transient stress-relaxation tests (shear strain range: 0.02-0.15 rad) were performed. The annulus fibrosus material was less stiff and more dissipative at larger shear strain amplitudes, stiffer at higher frequencies of oscillation, and stiffer and less dissipative at larger axial compressive stresses. The dynamic shear modulus, /G*/, had values ranging from 100 to 400 kPa, depending on the experimental condition and degenerative level. The shear behavior was also predominantly elastic, with values for the tangent of the phase angle (tandelta) ranging from 0.1 to 0.7. The annulus material also became stiffer and more dissipative with degenerative grade; however, this was not statistically significant. The results indicated that nonlinearities, compression/shear coupling, intrinsic viscoelasticity, and, to a lesser degree, degeneration all affect the shear material behavior of the annulus fibrosus, with important implications for load-carriage mechanisms in the intervertebral disc. These material complexities should be considered when choosing material constants for finite element models.
Di-tert-butylsilylene-Directed α-Selective Synthesis of 4-Methylumbelliferyl T-Antigen (2005)

[reaction: see text] We have succeeded in the facile synthesis of 4-methylumbelliferyl T-antigen as a substrate for endo-alpha-N-acetylgalactosaminidase by exploiting the combination of the di-tert-butylsilylene effect and the Mitsunobu reaction.
A Comparison of Two Regimens for the Treatment ofMycobacterium aviumComplex Bacteremia in AIDS: Rifabutin, Ethambutol, and Clarithromycin versus Rifampin, Ethambutol, Clofazimine, and Ciprofloxacin (1996)

In patients with AIDS and M. avium complex bacteremia, treatment with the three-drug regimen of rifabutin, ethambutol, and clarithromycin leads to resolution of the bacteremia more frequently and more rapidly than treatment with rifampin, ethambutol, clofazimine, and ciprofloxacin, and survival rates are better.
A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder (2021)

Gliosis is implicated in the pathophysiology of many neuropsychiatric diseases, including treatment-resistant major depressive disorder (TRD). Translocator protein total distribution volume (TSPO V<sub>T</sub>), a brain marker mainly reflective of gliosis in disease, can be measured using positron emission tomography (PET). Minocycline reduces gliosis and translocator protein binding in rodents, but this is not established in humans. Here, the ability of oral minocycline to reduce TSPO V<sub>T</sub> was assessed in TRD. To determine whether oral minocycline, as compared to placebo, can reduce prefrontal cortex (PFC), anterior cingulate cortex (ACC), and insula TSPO V<sub>T</sub> in TRD, twenty-one TRD participants underwent two [<sup>18</sup>F]FEPPA PET scans to measure TSPO V<sub>T</sub>. These were completed before and after either oral minocycline 100 mg bid or placebo which was administered in a randomized double-blinded fashion for 8 weeks. There was no significant difference between the minocycline and placebo groups on change in TSPO V<sub>T</sub> within the PFC, ACC, and insula (repeated measures ANOVA, effect of group interaction, PFC: F<sub>1,19</sub> = 0.28, P = 0.60; ACC: F<sub>1,19</sub> = 0.54, P = 0.47; insula F<sub>1,19</sub> = 1.6, P = 0.22). Oral minocycline had no significant effect on TSPO V<sub>T</sub> which suggests that this dosage is insufficient to reduce gliosis in TRD. To target gliosis in TRD either alternative therapeutics or intravenous formulations of minocycline should be investigated. These results also suggest that across neuropsychiatric diseases in humans, it should be assumed that oral minocycline will not reduce TSPO V<sub>T</sub> or gliosis unless empirically demonstrated.
The benefits of tax-deductible equity (1997)

Since the creation of tax-deductible preferred in late 1993, this form of financing has been a popular means of financing. The main attraction for issuers is the ability to essentially increase equity levels while taking advantage of the tax-deductibility of debt. This paper discusses the issues involved in issuing tax-deductible preferred and the performance results of the issuers over time.
Maxon is an Optimal Suture for Bile Duct Anastomoses in Pigs (1993)

Maxon is an optimal suture for bile duct anastomoses. Its long term absorption characteristics make it suitable for situations where bile duct healing may be delayed.
ChemInform Abstract: Reaction of Halothane with Carbonyl Compounds in the Presence of Lithium Diisopropylamide. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mathematical Models of Human Learning (2023)

Although learning was a key focus during the early years of mathematical psychology, the cognitive revolution of the 1960s caused the field to languish for several decades. Two breakthroughs in neuroscience resurrected the field. The first was the discovery of long-term potentiation and long-term depression, which served as promising models of learning at the cellular level. The second was the discovery that humans have multiple learning and memory systems that each require a qualitatively different kind of model. Currently, the field is well represented at all of Marr’s three levels of analysis. Descriptive and process models of human learning are dominated by two different, but converging, approaches – one rooted in Bayesian statistics and one based on popular machine-learning algorithms. Implementational models are in the form of neural networks that mimic known neuroanatomy and account for learning via biologically plausible models of synaptic plasticity. Models of all these types are reviewed, and advantages and disadvantages of the different approaches are considered.
Supplementary Table 2 from The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis (2023)

&lt;p&gt;PDF file - 116K, Supplemental Table S2 - Myc-CaP + Twist1-F191G versus Myc-CaP + Vector Differentially.&lt;/p&gt;
Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways. (1998)

Hepatocyte growth factor and KGF activate Ras-MAPK pathways in human corneal epithelial cells. There may be at least two routes used by HGF in transmitting signals from its receptor to the MAPK cascade. One is the receptor-Grb2/Sos complex to the Ras pathway, and the other is through protein kinase C. Hepatocyte growth factor and KGF did not activate the Jak-STAT cascade components STAT1, STAT3, or Jak1 in corneal epithelial cells.
Advanced technology zinc/chlorine batteries for electric utility load-leveling (1984)

Analytical studies of alternative designs for zinc/chlorine batteries using a number of advanced technologies have been made. As a result, a new design for zinc/chlorine batteries for electric utility load-leveling has been developed. In this new design, ambient pressure liquid chlorine for storage and plastic-bonded carbon electrodes in flow-through bipolar cell-stacks are proposed. Cell-stacks are arranged in modules of 400kWh capacity, and the latter are interconnected in parallel and series arrays to form a 100MWh battery plant. The advantages of the new design have been delineated.
Developing Java Servlets (1999)

From the Publisher:
Developing Java Servlets, Second Edition, is a comprehensive, code-intensive book for professional Java developers. It explains the Java Servlet API architecture and client/server development concepts and contains detailed, professional programming techniques for building sophisticated e-commerce and database servlet applications. New topics covered in the updated edition are:
JavaMailServlets with XML, JSP, and EJBPluggable web applicationsWireless servlets with WML/WMLScripts
Examining the Mapping Functions of Denoising Autoencoders in Music Source Separation (2019)

Support material for the article: "Examining the Mapping Functions of Denoising Autoencoders in Music Source Separation".<br> It contains the code for: Analyzing an open-access dataset Implementations of the Denoising Autoencoder and the variants for music source separation Loss functions employed in the article The algorithm that is denoted as the Neural Couplings Algorithm (NCA) Reproducing the figures of the corresponding article Toy-examples for the gradient calculation It also contains binary files used in: Creating the segments for the testing of the NCA and creating the corresponding visualizations The optimized models' weights Python requirements text file How to use: Install the requirements Set the data-set paths in "processes_scripts/run_me.py" and "processes_scripts/analyze_data.py" Run "process_scripts/analyze_data.py" to analyze and store the spectral data for training the models Run "process_scripts/run_me" to train (in the case that re-training is necessary with "training_flag = True") and to compute the linearly composed matrices for reproducing one of the figures Run "process_scripts/run_couplings.py" to plot the average linear composition, evaluate the strategies of the NCA algorithm and make plots on specific test data. TBD: Github gist for the NCA algorithm Pytorch and python updates
Field Foam Applications in Enhanced Oil Recovery Projects: Screening and Design Aspects (1998)

Abstract An in-depth analysis was conducted for over forty foam applications in Enhanced Oil Recovery (EOR) projects, and numerous production well treatment operations involving the use of foam in cyclic steam operations and in gas miscible floods, to derive insights on screening and design aspects in such applications. Foam can be used to solve conformance problems caused by either a thief zone or gravity override; The proper identification of the cause, as well as of the production well(s) affected is basic to the definition of the problem. Either blocking/diverting foams or in-depth mobility control foams can be placed through the injection wells. On the other hand, foam treatment in production wells is done mainly to mitigate an override problem. The most important factors in foam assisted EOR projects were determined to be: (a) manner of foam placement in the reservoir (injection of pre-formed foam, co-injection foam and SAG or surfactant alternating gas foam), (b) reservoir pressure and c) permeability. While pre-formed foam are effective mainly in the treatment of the production wells, the co-injection foam and SAG can be employed for solving specific sweep efficiency problems in EOR projects. It is concluded that for designing a steam-foam project (which is essentially a low pressure foam application) a foam quality in the range 45% to 80% should be considered. In this kind of application, a co-injection foam is to be employed and the additives (surfactant and non-condensable gas) are to be injected intermittently (on and off), superimposed on a continuous steam injection. Injection cycles as short as 7 days (2 days-on and 5 days-off) should be considered. Under suitable conditions, an oil rate increase of 1.5 to 5 times, a decrease in water cut by 20 %, and an incremental oil recovery of 6%-12% OOIP can be achieved with such an implementation. At high pressure, such as in gas miscible flooding (CO2 and hydrocarbon gas), foam application can result in excessive mobility reduction factors, and injectivity reduction. Due to this reason, alternate injection of surfactant solution and gas (SAG foam) is favoured over a co-injection mode of placement. Recommendations for laboratory tests in support of a proper design of the field pilot are presented.
Table S1 from Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study) (2023)

&lt;p&gt;Baseline disease characteristics by treatment arm&lt;/p&gt;
Efficient Hybrid Packet Classification in Traffic Control System Using Network Processors (2009)

The fast increasing Internet applications need accurate, high performance and scalable packet classification in traffic control systems. Although there are several designs of packet classification implemented on heterogeneous hardware platforms, accurate and ultra-speed packet classification remains elementary. The disparity arises because traditional packet classification algorithms with imprecise port-based method and packet processing have unacceptably memory access latency. This paper discusses an efficient hybrid packet classification in gigabits traffic control systems using second-generation programmable network processor. Firstly, we address the problem of inaccurate packet classification and analyze the payload of applications. Secondly, we present the packet classification using not only packet header but the first 64-bit payload. Finally, we describe the software pipeline architecture and hardware design for our approach with network processor. Compared with traditional solutions, the hybrid packet classification has 93% accuracy and speed up to 7.6Gbps in a real network environment.
Work-in-Progress: Design Concept of a Lightweight Runtime Environment for Robot Software Components Onto Embedded Devices (2018)

Although ROS (Robotic Operating System) has attracted attention to enhance the productivity of robot software development, it is necessary to adopt the device with high function and large power consumption enough to install Linux. This paper designs a lightweight runtime environment of ROS nodes onto mid-range embedded devices. Our environment, that is named to mROS, consists of a real-time OS and TCP/IP protocol stack to provide a tiny ROS communication library. mROS provides the connectivity to host and other ROS nodes with the native ROS network protocol. One of advantages for mROS is that native ROS nodes can be ported from Linux-based systems to RTOS-based systems since APIs with the same name of native ROS can be used in the embedded program. Experimental results validate that the performance requirement of mROS can be achieved for the construction of distributed robot systems.
Pleiotropic Effects of Inactivating a Carboxyl-Terminal Protease, CtpA, in Borrelia burgdorferi (2004)

A gene encoding a putative carboxyl-terminal protease (CtpA), an unusual type of protease, is present in the Borrelia burgdorferi B31 genome. The B. burgdorferi CtpA amino acid sequence exhibits similarities to the sequences of the CtpA enzymes of the cyanobacterium Synechocystis sp. strain PCC 6803 and higher plants and also exhibits similarities to the sequences of putative CtpA proteins in other bacterial species. Here, we studied the effect of ctpA gene inactivation on the B. burgdorferi protein expression profile. Total B. burgdorferi proteins were separated by two-dimensional gel electrophoresis, and the results revealed that six proteins of the wild type were not detected in the ctpA mutant and that nine proteins observed in the ctpA mutant were undetectable in the wild type. Immunoblot analysis showed that the integral outer membrane protein P13 was larger and had a more acidic pI in the ctpA mutant, which is consistent with the theoretical change in pI for P13 not processed at the carboxyl terminus. Matrix-assisted laser desorption ionization-time of flight data indicated that in addition to P13, the BB0323 protein may serve as a substrate for carboxyl-terminal processing by CtpA. Complementation analysis of the ctpA mutant provided strong evidence that the observed effect on proteins depended on inactivation of the ctpA gene alone. We show that CtpA in B. burgdorferi is involved in the processing of proteins such as P13 and BB0323 and that inactivation of ctpA has a pleiotropic effect on borrelial protein synthesis. To our knowledge, this is the first analysis of both a CtpA protease and different substrate proteins in a pathogenic bacterium.
Preparation of a liquid benzoxazine based on cardanol and the thermal stability of its graphene oxide composites (2014)

ABSTRACT A novel liquid benzoxazine was synthesized by Mannich reaction of cardanol, paraformaldehyde, and allylamine. The benzoxazine structure was characterized by 1 H‐NMR and FTIR. The liquid benzoxazine could dissolve easily in many solvents. The curing behavior of the benzoxazine was characterized by differential scanning calorimetry (DSC) and its curing temperature was about 233°C. A benzoxazine‐functional silane coupling agent (BFSca) was synthesized with paraformaldehyde, phenolphthalein, and aminopropyltriethoxysilane. Graphene oxide (GO) was also made via improved Hummer's method. Then benzoxazine/GO composites were prepared using BFSca by solution blending and the curing behaviors of the composites were also characterized by IR, DSC, and thermogravimetric analysis. The minimum curing temperature and the highest 5% weight loss temperature for the composites was, respectively, 185 and 399.8°C. The SEM images of benzoxazine/GO composites demonstrated that BFSca had improved the dispersion of GO in the benzoxazine and also enhanced the thermal decomposition temperature of the composites. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40353.
Asymmetric aldol reaction of isatins with acetone in the presence of terpene amino alcohols (2020)

Asymmetric aldol reactions of isatin and 4,6-dibromoisatin with acetone are efficiently catalyzed by β-amino alcohols derived from α-pinene and 3-carene. The target compounds can be isolated by crystallization from toluene, which eliminates the need for using chromatography and makes the asymmetric synthesis of (R)-convolutamydine A (up to 94% ee and yield 75%) simple and convenient.
Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling (2011)

α-Pyrones and pyrimidones are common structural motifs in natural products and bioactive compounds. They also display photochemistry that generates high-energy intermediates that may be capable of protein reactivity. A library of pyrones and pyrimidones was synthesized, and their potential to act as photoaffinity probes for nondirected affinity-based protein profiling in several crude cell lysates was evaluated. Further "proof-of-principle" experiments demonstrate that a pyrimidone tag on an appropriate scaffold is equally capable of proteome labeling as a benzophenone.
Determinants of intensity of participation in leisure and recreational activities by children with cerebral palsy (2010)

Intensity of participation of children with CP is influenced by multiple child and family determinants. Children's gross motor function and behavior in life situations are important for participation; knowledge of activities the child and family enjoy has implications for opportunities for participation. Professionals are encouraged to address priorities for leisure and recreation identified by children with CP and their families.