gebhart/patrepeval huggingface dataset:
Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways (1999)

To investigate eosinophil stimulation by chemokines we developed a sensitive assay of leukocyte shape change, the gated autofluorescence/forward scatter assay. Leukocyte shape change responses are mediated through rearrangements of the cellular cytoskeleton in a dynamic process typically resulting in a polarized cell and are essential to the processes of leukocyte migration from the microcirculation into sites of inflammation. We examined the actions of the chemokines eotaxin, eotaxin-2, monocyte chemoattractant protein-1 (MCP-1), MCP-3, MCP-4, RANTES, macrophage inflammatory protein-1alpha (MIP-1alpha), and IL-8 on leukocytes in mixed cell suspensions and focused on the responses of eosinophils to C-C chemokines. Those chemokines acting on CCR3 induced a rapid shape change in eosinophils from all donors; of these, eotaxin and eotaxin-2 were the most potent. Responses to MCP-4 were qualitatively different, showing marked reversal of shape change responses with agonist concentration and duration of treatment. In contrast, MIP-1alpha induced a potent response in eosinophils from a small and previously undescribed subgroup of donors via a non-CCR3 pathway likely to be CCR1 mediated. Incubation of leukocytes at 37 degrees C for 90 min in the absence of extracellular calcium up-regulated responses to MCP-4 and MIP-1alpha in the majority of donors, and there was a small increase in responses to eotaxin. MIP-1alpha responsiveness in vivo may therefore be a function of both CCR1 expression levels and the regulated efficiency of coupling to intracellular signaling pathways. The observed up-regulation of MIP-1alpha signaling via non-CCR3 pathways may play a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung.
Power optimization using divide-and-conquer techniques for minimization of the number of operations (1997)

We develop an approach to minimizing power consumption of portable wireless DSP applications using a set of compilation and architectural techniques. The key technical innovation is a novel divide-and-conquer compilation technique to minimize the number of operations for general DSP computations. Our technique optimizes not only a significantly wider set of computations than the previously published techniques, but also outperforms (or performs at least as well as other techniques) on all examples. Along the architectural dimension, we investigate coordinated impact of compilation techniques on the number of processors which provide optimal trade-off between cost and power. We demonstrate that proper compilation techniques can significantly reduce power with bounded hardware cost. The effectiveness of all techniques and algorithms is documented on numerous real-life designs.
Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana (2014)

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalysed by TPS (trehalose-6-phosphate synthase) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct clades: class I (AtTPS1-AtTPS4) and class II (AtTPS5-AtTPS11). Only AtTPS1 has previously been shown to have TPS activity. A. thaliana tps1∆ mutants fail to complete embryogenesis and rescued lines have stunted growth and delayed flowering, indicating that AtTPS1 is important throughout the life cycle. In the present study, we show that expression of AtTPS2 or AtTPS4 enables the yeast tps1∆ tps2∆ mutant to grow on glucose and accumulate Tre6P (trehalose 6-phosphate) and trehalose. Class II TPS genes did not complement the yeast mutant. Thus A. thaliana has at least three catalytically active TPS isoforms, suggesting that loss of Tre6P production might not be the only reason for the growth defects of A. thaliana tps1 mutants.
Vascular Cholinesterases and Choline Uptake in Isolated Rat Forebrain Microvessels: A Possible Link (1989)

The two parameters of the active [methyl-3H]choline uptake into isolated rat forebrain microvessels, Km and Vmax, were determined for 1-, 3-, 10-, and 24-month-old Charles River male rats and compared with the activities of the enzymes choline acetyltransferase (ChAT), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) in these microvessels over the same time course. The value of Km remained constant over the entire period, but that of Vmax increased from 8.5 +/- 1.0 to 80.6 +/- 16.4 nmol g-1 (mean +/- SEM) over the first 3 months of life. Over the same period, the increase in ChAT activity, from an initial value of 7.1 +/- 1.6 to 10.2 +/- 0.3 nmol g-1 min-1, was not proportional to that of choline uptake. Levels of BuChE activity (0.9-1.3 mumol g-1 min-1) were almost unchanged throughout the entire 24-month period, but those of AChE showed a steady and significant increase from 1 to 24 months, remaining relatively high at senescence (4.7 mumol g-1 min-1), when choline uptake had decreased to one-third of its optimal value. Selective inhibition of AChE with 1,5-bis(4-allyldimethylammonium-phenyl)pentan-3-one dibromide (0.5 microM) in unruptured capillaries from 3-month-old rats resulted in a decrease in Vmax of choline uptake from approximately 81 to 59 nmol g-1 min-1 or with 9-amino-1,2,3,4-tetrahydroacridine (10 microM) in capillaries from 2-month-old rats from approximately 30 to 15 nmol g-1 min-1. Selective inhibition of BuChE with tetraisopropyl pyrophosphoramide (100 microM) resulted in an increase in Vmax from approximately 81 to 96 nmol g-1 min-1. It is possible that the two vascular enzyme systems are coupled to a hypothetical endothelial choline transporter, but with an action opposite to each other.
Acidization of Analcime-Cemented Sandstone, Gulf of Mexico (1990)

ABSTRACT In a number of offshore Louisiana oil wells a white powdery, finely granular siliceous material was swabbed from wells and found on screens after acidizing with mud acid. The white material was analyzed as silica gel or aluminosilicate gels. Analysis of the formation sands which produced the white material after acidization shows the sands to be extensively cemented with analcime. Analcime is a hydrated sodium aluminosilicate related to zeolites. Analcime is a low density (2.3 gm/cc) mineral which is highly soluble in HF and will form hydrated gels with concentrated HC1. Analcime is associated with volcanic ashes, altered volcanic sandstones and salt domes. There are many salt dome related oil fields in the central Gulf where volcanic ash beds are locally common. Therefore, the occurrence of analcime cemented sandstones may be more widespread in the Gulf than previously suspected. A significant production decline was noted in a number of wells in the South Pass Blk. 61 field, a complex salt dome related structure, after acidization with HF or concentrated HC1. In many cases, production decline is attributed to damage by mineral precipitation or gel formation from acid spent on analcime-cemented sands. This paper describes the petrographic and fluid/rock studies done to optimize pre and/or post gravel pack acid stimulation system for analcime- cemented sandstones from South Pass Blk. 61. SEM photos show the effect of various acid systems on analcime and an effective acid system for these types of formations is discussed.
Study of the effect of dielectric porosity on the stress in advanced Cu/low-k interconnects using x-ray diffraction (2009)

High intensity x-rays at an advanced light facility were used to probe the strained atomic spacing of Cu interconnects embedded in ultralow-k dielectrics of different porosities. The assumption that the strain-free atomic spacing of a thin film can be extrapolated from a relationship based on the material stiffness coefficients used in literature is tested and demonstrated experimentally using a series of blanket wafers. This is used to calculate the stress of 100 nm interconnects. High porosity materials show in-plane relaxation reducing the stress. The air gap architecture is shown to provide little constraint with the lowest Cu stress.
Local atomic structure in amorphous Fe-P alloys (1988)

Amorphous alloys Fex P100−x have been fabricated by rf sputtering in the composition range 50≤x≤75. Only a-Fe75 P25 is ferromagnetic at 293 K, with its Mössbauer spectrum consisting of six broad lines. This simple spectrum differs markedly from that of c-Fe3 P. Similarly, thermogravimetric analysis yielded Tc=550 K for the amorphous phase, a value considerably lower than that of the crystalline phase (700 K). The Mössbauer spectra of the samples having x≤71 were all similar quadrupole-split doublets. Mean isomer shifts (IS) and P(H) and P(Q) distributions were determined using Window’s method. The isomer shift is nearly independent of concentration in the range studied here, but differs significantly from those of the crystalline compounds c-FeP, c-Fe2 P, and c-Fe3 P. The effective quadrupole interaction is also nearly constant for 50≤x≤71, indicating a similar local Fe environment. These results contrast sharply with c-Fe2 P and c-FeP, which have different crystal symmetries and whose quadrupole interactions differ substantially both from each other and from their amorphous counterparts.
From BPMN Process Models to BPEL Web Services (2006)

The business process modelling notation (BPMN) is a graph-oriented language in which control and action nodes can be connected almost arbitrarily. It is supported by various modelling tools but so far no systems can directly execute BPMN models. The business process execution language for Web services (BPEL) on the other hand is a mainly block-structured language supported by several execution platforms. In the current setting, mapping BPMN models to BPEL code is a necessary step towards unified and standards-based business process development environments. It turns out that this mapping is challenging from a scientific viewpoint as BPMN and BPEL represent two fundamentally different classes of languages. Existing methods for mapping BPMN to BPEL impose limitations on the structure of the source model. This paper proposes a technique that overcomes these limitations. Beyond its direct relevance in the context of BPMN and BPEL, this technique addresses difficult problems that arise generally when translating between flow-based languages with parallelism
Frequency-Stabilized Diode-Laser-Pumped Solid State Lasers: Optical Clocks of the Future (1992)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Ady Arie, Eric K. Gustafson, and Robert L. Byer, "Frequency-Stabilized Diode-Laser-Pumped Solid State Lasers: Optical Clocks of the Future," Optics & Photonics News 3(12), 43-44 (1992) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Suppl Fig legends from Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53 (2023)

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Optical high frequency test structure and test bench definition for on wafer silicon integrated noise source characterization up to 110 GHz based on Germanium-on-Silicon photodiode (2013)

A new Optical-High-Frequency test structure and dedicated test bench have been developed to characterize a Germanium-on-Silicon photodiode intended to be used as an integrated noise source, a first step to high frequency transistor noise figure on-wafer extraction. Continuous wave signals have been measured from these 1550 nm photodiodes, with RF power higher than -20 dBm at 109 GHz.
Nanovolume Analysis with Secondary Ion Mass Spectrometry Using Massive Projectiles (2006)

A variant of secondary ion mass spectrometry is presented where the surface is bombarded with individual gold nanoparticles each resolved in time and space with a corresponding event-by-event detection of the secondary ions (SIs). The projectile used, Au400(4+), with impact energy of 136 keV, generates high SI yields. Typically, there is co-emission of multiple SIs from a single impact, i.e., emission of SIs from molecules co-located within a nanovolume with dimensions in the 10-nm range. The ability to detect co-located molecules was tested on samples consisting of alternating nanometric layers of oppositely charged polyions, poly(diallyldimethylammonium chloride), poly(styrenesulfonate) (PSS), and clay nanoplatelets. To achieve signal statistics, the chemical analysis was carried out with a sequence of stochastic impacts making this method suitable for characterization of similar nanoparticles or spots dispersed on a surface. Attomole detection sensitivity was achieved for PSS. The homogeneity of assembled layers could be assessed with approximately 10-nm resolution.
Using caloric efficiency to estimate the net energy value of expelled, extruded soybean meal relative to dehulled, solvent-extracted soybean meal and its effects on growth performance of nursery pigs, (2022)

This study aimed to estimate the net energy (NE) value of expelled, extruded soybean meal (MSBM) relative to dehulled, solvent-extracted soybean meal (SSBM) and determine its effects on growth performance of late nursery pigs. A total of 297 pigs (DNA 241 × 600) were weaned (BW 5.10 kg) and placed into 60 pens (2 rooms of 30 pens) with 5 pigs per pen balanced by gender and weaning weight. Pigs were fed a common diet for 21 d. Then, pens of pigs (BW 9.3 kg) were randomly assigned to one of five treatments to provide 12 replications per treatment. Treatments consisted of increasing amounts of MSBM replacing SSBM in the diet (0%, 25%, 50%, 75%, and 100%). All diets were fed for 28 d and were formulated to 1.30% standardized ileal digestible lysine and met or exceeded requirements for amino acids, calcium, and phosphorus. The SSBM diet was formulated to 2,421 kcal/kg and NE was not balanced between diets. Analyzed values for CP, EE, CF, and total lysine for the SSBM were 47.28%, 0.47%, 3.80%, and 3.00%, whereas the MSBM contained 47.41%, 6.88%, 5.32%, and 2.99%, respectively. The MSBM had increased values for KOH solubility and trypsin inhibitor (83.62% and 7,026 TIU/g) compared to the SSBM (73.05% and 3,011 TIU/g), whereas urease activity was similar between the two (0.03 and 0.02 Δ pH, respectively). Data were analyzed using Proc GLIMMIX (SAS 9.4; Cary, NC) with pen as the experimental unit and room as the blocking factor. There was no evidence of differences in ADG and ADFI in pigs fed diets with increasing concentrations of MSBM. Pigs fed diets with increasing concentrations of MSBM had improved (linear, <i>P </i>< 0.001) G:F and caloric efficiency on an NE basis. Using caloric efficiency to estimate NE of the MSBM relative to SSBM, MSBM was estimated to have a value of 2,566 kcal/kg. In conclusion, MSBM contains approximately 123% of the energy of SSBM, which improved feed efficiency when fed to nursery pigs.
Posttraumatic Stress Disorder and Quality of Life (2002)

Sertraline treatment of chronic PTSD is associated with rapid improvement in quality of life that is progressive and sustained over the course of more than 1 year of treatment.
High-speed wireless infrared links with an adaptive multibeam clustering method and angle diversity detection (2012)

In this paper, we propose a mobile optical wireless (OW) system that employs a beam delay and a power adaptation multibeam clustering method in conjunction with an angle diversity receiver (BDPA-BCM). Our ultimate goal is to improve the signal to noise ratio (SNR), reduce the delay spread and increase the received optical power under multipath dispersion, background noise and mobility. A significant reduction in delay spread by nearly a factor of fifteen and an enhanced SNR by almost 10 dB over a line strip multibeam system (LSMS) can be achieved when a beam delay and power adaptation line strip multibeam system (BDPA-LSMS) coupled with an angle diversity receiver is employed. At a bit rate of 50 Mbit/s, the proposed BDPA-BCM offers about a 10 dB SNR gain over a BDPA-LSMS. A further improvement in the delay spread of the BDPA-BCM by a factor of eight compared with the BDPA-LSMS is achieved. The improvements in the delay spread and the SNR enable the BDPA-BCM to operate at higher data rates of 2.5 Gb/s and 5 Gb/s. Our simulation results show that the modified BDPA-BCM at a bit rate of 5 Gb/s achieves about 16 dB SNR for the worst communication path under the presence of background noise and mobility while achieving a BER below 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> .
L’expérimentation animale reste indispensable (OPINION) (2017)

Trop fréquemment, l’expérimentation animale est présentée comme une pratique archaïque. Elle a bien changé. Et 100 % des patients traités le sont grâce aux concepts et techniques développés grâce à elle.
Arc plasma assisted rotating electrode process for preparation of metal pebbles (2014)

Spherical beryllium pebbles of size ranging from 0.2-2 mm are required as neutron multiplying material in solid Test Blanket Module (TBM) of International Thermonuclear Experimental Reactor (ITER). Rotating electrode process (REP) has been identified as a suitable technique for preparation of beryllium pebbles. In REP, arc plasma generated between non-consumable electrode (cathode) and rotating metal electrode (anode) plays a major role for continuous consumption of metal electrode and preparation of spherical metal pebbles. This paper focuses on description of the process, selection of sub-systems for development of REP experimental set up and optimization of arc parameters, such as, cathode geometry, arc current, arc voltage, arc gap and carrier gas flow rate for preparation of required size spherical metal pebbles. Other parameters which affect the pebbles sizes are rotational speed, metal electrode diameter and physical properties of the metal. As beryllium is toxic in nature its surrogate metals such as stainless steel (SS) and Titanium (Ti) were selected to evaluate the performance of the REP equipment. Several experiments were carried out using SS and Ti electrode and process parameters have been optimized for preparation of pebbles of different sizes.
Towards automatic privacy management in Web 2.0 with semantic analysis on annotations (2009)

Sharing personal information and documents is pervasive in Web 2.0 environments, which creates the need for properly controlling shared data. Most existing authorization and policy management systems are for organizational use by IT professionals. Average Web users, however, do not have the sophisti
Influence of AC on Corrosion Kinetics for Carbon Steel, Zinc and Copper (2005)

Abstract Previous works showed that AC can affect corrosion overpotential of corroding metals. In order to understand this experimental evidence, galvanostatic polarization tests on carbon steel, zinc and copper in 1 M solution of their ions were performed at AC current densities of 0, 30, 100, 300, 500 and 1,000 A/m2. The influence of AC on kinetics parameters such as Tafel slope and exchange current densities was therefore evaluated. The results confirmed that models based on a pure faradaic effect are not sufficient to fully describe the effects of AC on corrosion if the processes occurring at the interface are not completely reversible. In that case, the metal-solution interface could be altered by the AC signal affecting the corrosion kinetics.
Electric dipole polarizability of one excess-electron alkali–halide cluster (2000)

In this communication, we present the first measurement of the electric dipole polarizability of alkali–halide clusters with one excess electron. The polarizability is strongly size dependent. Very large values are observed for certain sizes. Ionization potential measurement is also presented for comparison.
Guest Editorial: Body Sensor Networks (2018)

As researchers from both academia and industry strive towards the goals of improving the patients' quality of life and reducing health costs, Body Sensor Networks (BSNs)are one of the very promising research areas that can help achieve both goals.
Molecular biology and pathology of type VII collagen* (1992)

Type VII collagen is a genetically distinct member of the collagen family of proteins. Type VII collagen has been shown to be the major component of anchoring fibrils, attachment complexes which secure the cutaneous basement membrane of the skin to the underlying dermis. Understanding of the structure of type VII collagen has been advanced by recent cloning of the corresponding gene. Chromosomal mapping of the gene to the short arm of chromosome 3 and identification of intragenic polymorphic markers have allowed demonstration of strong genetic linkage between the type VII collagen locus and the dystrophic forms of EB (epidermolysis bullosa). This overview summarizes the progress made in the molecular genetics of type VII collagen.
167 Quality of Life in Men Undergoing Radical Prostatectomy for Prostate (2010)

Prostate cancer is the most common noncutaneous cancer in men and the secondleading cause of death from cancer in men in the United States. Approximately one in six men will be diagnosed with the disease during his lifetime. When a man is diagnosed with clinically localized prostate cancer, he is immediately faced with a number of complex issues regarding the management of the disease. Options available to him include surgical management in the form of radical prostatectomy, radiotherapy including external beam radiation therapy and brachytherapy, hormone ablation, and expectant management or active surveillance (i.e., ‘‘watchful waiting’’). Radical prostatectomy remains one of the most important tools for localized disease – a ‘‘goldstandard’’ for definitive treatment to which novel therapies are compared (> Table 167-1). It is estimated that in the United States that approximately 77,000 of the procedures are performed annually. To assist clinicians along these lines, several validated questionnaires have been developed and are commonly used to monitor quality of life changes in patients as they relate to treatment of localized prostate cancer. Providers who treat localized prostate cancer should be familiar with and utilize these instruments as part of their routine post-treatment evaluation of patients over time (> Table 167-2). Improved understanding of the side effects of interventions and their impact of healthrelated quality of life (HRQOL) is an important part of understanding of the impact of the cancer as well as the modalities to treat the malignancy. To this end, HRQOL assessments have become and important area of interest with respect to radical prostatectomy. Researchers have evaluated many different aspects of this topic, including the impact of comorbidities, socioeconomic status, type of prostatectomy, as well as comparisons to other treatments for prostate cancer. However, despite the potential for side effects, overall satisfaction with the surgery remains high, and patients report little decrease in their overall quality of life. A thorough understanding of these issues is essential for clinicians who must assist their patients through complicated decision processes once they are diagnosed with localized prostate cancer. List of Abbreviations: EBRT, external beam radiation therapy; EORTC QLQ-C30, the European organization for research and treatment of cancer core quality of life questionnaire with its prostate cancer specific module; EPIC, the expanded prostate cancer index-composite; FACT-P, The functional assessment of cancer therapy-prostate instrument; HRQOL, healthrelated quality of life; RALRP, robotic-assisted laparoscopic radical prostatectomy; SES, socioeconomic status; UCLA PCI, The UCLA prostate cancer index