gebhart/patrepeval huggingface dataset:
Abstract 3777: Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell lines (2014)

Abstract Introduction: The survival trends for glioblastoma (GBM) patients have remained largely static, reflecting lack of improvement in the therapeutic options for patients. Less than 5% of newly diagnosed GBM survive more than 5 years. Standard treatment for GBM comprises of radiotherapy and temozolomide (TMZ) chemotherapy (chemoradiotherapy). Methylation of the promoter region of MGMT has been shown to be predictive of response to chemoradiotherapy. Approximately 30% of GBM are MGMT methylated. ABT-888 (Veliparib; Abbvie) is a Poly (ADP-ribose) polymerase (PARP) inhibitor that has been shown to enhance response of GBM to chemoradiotherapy in MGMT methylated patients. However, despite response (and lack of response in the case of MGMT unmethylated patients), recurrent GBM is refractory to treatment, occurring 2-3cm from the original resection and patient die within few months after recurrence. Herein we demonstrate the use of ABT-888 might be effective in patients who have recurrent GBM. Methods: We tested ABT-888 alone and in combination with TMZ on low passage patient derived cell lines cultured from patients with recurrent GBM. We have used low passage patient derived cells including BAH and HW that are MGMT methylated. We also used U87, U251 and LN229 that are immortalized cells that are MGMT methylated. Of these lines, only U251 harbors a mutation in the binding domain of TP53. We also tested MGMT methylated low passage patient derived cell lines where TMZ resistance was selected for through continuous TMZ treatment of the cell line. Results: Consistent with previous studies, monotherapy with ABT-888 was largely ineffective on all of the cell lines. We combined a low dose of ABT-888 (5μM) with a range of TMZ concentrations. Combination treatment was highly efficacious with sensitivity to TMZ improved by 30-70% when tested in 5 recurrent cell lines. All cell lines were MGMT unmethylated. We continuously treated 3 cell lines (2 MGMT methylated and 1 MGMT unmethylated) with TMZ until resistance was achieved. We found a response to the ABT-888/ TMZ combination was dramatic. Cells were 75% more sensitive to ABT-888/TMZ compared to retreatment with TMZ. Conclusion: This novel strategy of combining ABT-888 with TMZ demonstrated synergistic antitumor activity for the treatment of relapsed and/or “chemo-resistant” GBM cell lines. Further investigation of this synergy has potential for rapid translation into clinical studies. Citation Format: Kerrie McDonald, Kyoko Nozue-Okada, Mustafa Khasraw. Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3777. doi:10.1158/1538-7445.AM2014-3777
1A2-R17 Hybrid Head-Mounted/Projection Display System for Telexistence and Remote Behavior Navigation(VR and Interface) (2013)

A Head Mounted Display (HMD) is the most popular display device for Virtual Reality (VR), Augmented Reality (AR), Mixed Reality (MR), Telexistence, and remote Behavior Navigation. However, it is difficult to realize both large field of view (FOV) and natural correspondence between the displayed image and the real image with an HMD. In order to improve the performance of the HMD, we propose the simultaneous utilization of both a slenderized HMD for central vision and a projection display for peripheral vision. In this paper, the configuration of the prototype of the HMD/projector hybrid display system, and the experimental evaluation are presented.
Analytical solution for mode-mismatched thermal lens spectroscopy with sample-fluid heat coupling (2010)

This paper presents an improved theoretical description of the mode-mismatched thermal lens effect using models that account for heat transport both within the sample and out to the surrounding coupling medium. Analytical and numerical finite element analysis (FEA) solutions are compared and subsequently used to model the thermal lens effect that would be observed using continuous laser excitation. FEA model results were found to be in excellent agreement with the analytical solutions. The model results show that heat transfer to the air coupling medium introduces only a minor effect when compared with the solution obtained without considering axial air-sample heat flux for practical examples. On the other hand, the thermal lens created in the air coupling fluid has a relatively more significant effect on the time-dependent photothermal lens signals.
Assembly Configurations of Spatial RRRCC, RRCRC, RRRRCR, and RRRRRRR Mechanisms (2000)

Abstract This paper examines the problem of finding the assembly configurations, also called circuits, of spatial single-loop single-DOF mechanisms with five or more links. The RRRCC, RRCRC, RRRRCR, and RRRRRRR mechanisms are covered, along with all variations in which a revolute (R) joint is replaced by a prismatic (P) joint. A numerical method is given to find the ACs, and is illustrated with several examples.
Les monuments religieux (1910)

Klein Henri. Les monuments religieux. In: Les Feuillets d'El-Djezaïr, volume 2, 1910. Le Vieil Alger et l'occupation militaire française avec vues, plans et coupes. pp. 15-21.
Nuclear Transfer in Mouse Embryos: Activation of the Embryonic Genome (1985)

Following fertilization, normal development requires a strictly defined inventory of cellular components. These components, the products of male and female gametogenesis, reflect two distinct processes of differentiation. It is apparent that the transcriptional activity of the respective gametic nuclei must meet different morphogenetic and functional requirements. In the male, transcriptional activity persists into the haploid phase of spermatogenesis (Distel et al. 1984), whereas synthesis of poly(A)+ RNA in oocytes in the female continues beyond the completion of oocyte growth (Wassarman 1983). Thus, the male and female genomes at the moment of fertilization reflect functionally different germ cell lineages that must undergo a coordinated transition for the specification of embryo-specific gene products. This transition requires complex interactions among the pronuclei, the ovum cytoplasm, and their environment. The nature of these interactions and the individual contributions of each cellular component may be assessed by nuclear and cytoplasmic transfer. We present experiments in...
The In Vivo Response of Foetal Tendons to Sutures (1995)

The in vivo response of foetal flexor digitorum profundus tendons to tendon sutures was studied macroscopically and microscopically in foetal lambs. No tendon adhesions were noted at any of the examination intervals. 4 days after injury, a mild inflammatory reaction was noted around the suture. The tendon examined at the 4-week interval showed evidence of migration of epitenon cells from the outer surface of the tendon into the suture track. The tendon examined at the 6-week interval showed normal tendon fibres surrounding the suture site. Differences between foetal skin and foetal tendon healing are discussed along with the possible role of amniotic fluid in modulating the healing process in the foetus.
Detection of Acute HIV Infection: A Field Evaluation of the Determine® HIV-1/2 Ag/Ab Combo Test (2011)

Combo RT displayed excellent performance for detecting established HIV infection and poor performance for detecting acute HIV infection. In this setting, Combo RT is no more useful than current algorithms.
Sirolimus Prolongs Survival after Living Donor Liver Transplantation for Hepatocellular Carcinoma Beyond Milan Criteria: A Prospective, Randomised, Open-Label, Multicentre Phase 2 Trial (2020)

Sirolimus (SRL) has been reported to benefit patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). This study aimed to compare SRL with tacrolimus (TAC) in living-donor LT (LDLT) recipients beyond the Milan criteria. This study was initially designed to enrol 45 recipients who underwent LDLT for HCC beyond the Milan criteria. At 1 month after LT, the patients were randomly assigned to either SRL or TAC-based treatment, with both groups receiving mycophenolate mofetil. The primary outcome was three-year recurrence-free survival (RFS) and the secondary outcome was overall survival (OS). A total of 42 patients completed the study. HCC recurrence occurred in 8 of 22 (36.4%) patients in the SRL group and in 5 of 22 (25%) patients in the TAC group. No differences in RFS and OS were found between the two groups in simple comparison. The type of immunosuppressant remained a nonsignificant factor for recurrence in multivariate analysis; however, SRL significantly prolonged OS (TAC hazard ratio: 15 [1.3-172.85], <i>p</i> = 0.03) after adjusting for alpha-fetoprotein and positron emission tomography standardised uptake value ratio (tumour/background liver). In conclusion, SRL does not decrease HCC recurrence but prolongs OS after LDLT for HCC beyond the Milan criteria.
Survival prediction in terminal cancer patients: a systematic review of the medical literature (2000)

The clinical significance of studies on survival predictors in terminal cancer patients is hindered by both methodological limitations and the difficulty of finding common predictors for all final events in cancer related deaths. To evaluate the published medical literature concerned with the survival of patients with terminal cancer and identify potential prognostic factors, major electronic databases including MEDLINE (1966-), CANCERLIT (1983-) and EMBASE (1988-) were searched up to September 1999. Studies were included in our review if published in English, were cohort studies, addressed the identification of clinical prognostic factors for survival and looked at samples with median survival of < or = 3 months. Data extracted from selected papers included: sample size, median survival, type of study, sampling frame, cohort type, type of statistical analysis (univariate or multivariate), choice of models and underlying assumptions, predictors examined and their reported level of statistical significance. A total of 24 studies were found and reviewed. On the basis of these studies, performance status and the presence of cognitive failure, weight loss, dysphagia, anorexia and dyspnoea appear to be independent survival predictors in this population. Clinical estimation of survival by the treating physician appeared independently associated with survival but the magnitude of the association generally appeared small. Clinical predictions should be considered as one of many criteria, rather than as a unique criterion by which to choose therapeutic interventions or health care programmes for terminally ill cancer patients. The use of convenient samples as opposed to more representative inception cohorts, the inclusion of different variables in the statistical analyses and inappropriate statistical methods appear to be major limitations of the reviewed literature. Methodological improvements in the design and conduction of future studies may reduce the prognostic uncertainty in this population.
Selective dehydrogenation of propane over novel catalytic materials (1998)

The conversion of small alkanes into alkenes represents an important chemical processing area; ethylene and propylene are the two most important organic chemicals manufactured in the U.S. These chemicals are currently manufactured by steam cracking of ethane and propane, an extremely energy intensive, nonselective process. The development of catalytic technologies (e.g., selective dehydrogenation) that can be used to produce ethylene and propylene from ethane and propane with greater selectivity and lower energy consumption than steam cracking will have a major impact on the chemical processing industry. This report details a study of two novel catalytic materials for the selective dehydrogenation of propane: Cr supported on hydrous titanium oxide ion-exchangers, and Pt nanoparticles encapsulated in silica and alumina aerogel and xerogel matrices.
ENHANCED WEAR AND CORROSION IN MODULAR TAPERS IN TOTAL HIP REPLACEMENT - AN IN-VITRO BIOMECHANICAL STUDY (2012)

Introduction The National Joint Registry has recently identified failure of large head metal on metal hip replacements. This failure is associated with the high torque at the interface of standard modular taper junction leading to fretting and corrosion. A number of manufacturers produce mini spigots, which in theory, provide a greater range of motion as the neck head junction is reduced. However, the relative torque to interface ratio at this junction is also increased. In this study we investigated hypothesis that the use of small spigots (minispigots) will increase wear and corrosion on modular tapers. Methods Wear and corrosion of spigots were compared in-vitro when loaded with a force representative of the resultant force passing through the hip. The heads (female tapers) were made of cobalt-chrome-molybdenum (CoCrMo) and the stems (male tapers) of titanium alloy (Ti). Commercially available tapers and heads were used. The surface parameters & profiles were measured before & after testing. Electrochemical static and dynamic corrosion (pitting) tests were performed on minispigots under loaded and non-loaded conditions. Results Post-testing the surface parameters Ra, Ry & Rz on the head taper associated with the minispigots had become greater compared with standard spigots. In all instances the profile of the titanium male tapers was unchanged. SEM showed the corroded region of the head was similar to the profile on the Ti male taper, with evidence of pitting in the cobalt chrome. In the CoCrMo/ Ti combinations, wear and corrosion were increased in minispigots compared with standard spigots. On minispigots the rough surface finishes were affected more severely than those with a smoother surface. Static corrosion tests showed evidence of fretting in the rough but not the smooth minispigots. Pitting scans showed a greater hysteresis with the rough surface finishes on the minispogot indicating potentially greater corrosion in the former. Conclusion The relative size of the taper in comparison to the head combined with the surface finish was crucial. As the relative torque to interface ratio at this junction increased corrosion of the cobalt chrome head increases and is further enhanced if the surface finish on the tapers is rough.
Mathematical aspects of quantum annealing (2008)

Sufficient conditions for convergence of quantum annealing are derived for optimization problems represented by the Ising model. Three different types of time evolution are considered; the real-time Schrdinger equation, the path-integral Monte Carlo method and the Green's function Monte Carlo method. It is proved that the system under each dynamics reaches the target solution in the limit of infinite time if the transverse field, representing the strength of quantum fluctuations, decreases inversely proportionally to the power of time in the asymptotic region.
Tc-99m LABELED MONOCLONAL ANTIBODIES FOR IMAGING METASTATIC DISEASE. (1986)

Eary, Janet F.; Schroff, Robert W.; Kasina, Sudhakar; Fritzberg, Alan R.; Morgan, Alton C. Jr.; Krohn, Kenneth A.; Woodhouse, Clive; Abrams, Paul G.; Wil, B. Author Information
Quantitative SPECT brain imaging: effects of attenuation and detector response (1993)

Two reconstruction methods that compensate for attenuation and detector response, a 3-D maximum-likelihood (ML) expectation-maximization (EM) method and a filtered backprojection (FB) method with Metz filter and Chang attenuation compensation, were implemented and compared in terms of quantitative accuracy and image noise. The methods were tested on simulated data for the 3D Hoffman brain phantom. The simulation incorporated attenuation and distance-dependent detector response. Bias and standard deviation of reconstructed voxel intensities were measured in the gray- and white-matter regions. The results for ML showed that, in both regions, as the number of iterations increased, bias decreased and standard deviation increased. Similar results were observed for FB as the Metz filter power increased. In both regions, ML had a smaller standard deviation than FB for a given bias. Reconstruction times for the ML method have been greatly reduced through efficient coding and limited source support, and by computing attenuation factors only along rays perpendicular to the detector.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunological and Clinical Evaluation of Chagasic Patients Subjected to Chemotherapy during the Acute Phase ofTrypanosoma cruziInfection 14–30 Years Ago (2000)

We recently evaluated the in vitro proliferative response and interferon (IFN)-gamma production of peripheral blood mononuclear cells from a group of 25 people who were treated for Chagas' disease during the acute phase of Trypanosoma cruzi infection and followed up for a period of 14-30 years. On the basis of the parasitological and serological tests, the individuals were classified as cured (C), dissociated, or not cured (NC). Members of group C (the group without cardiac alterations) presented significantly stronger proliferative response against the parasite antigens, with secretion of high levels of IFN-gamma in comparison with the NC group, raising a question about the role of this cytokine in the curing of human T. cruzi infection. Severe cardiac alterations were observed only in 1 of 25 patients, which suggests that treatment benefited the patients.
[Singular graft's survival]. (2006)

Follicular unit extraction is a minimally invasive approach to hair transplantation that renders need of linear donor incision. Based on our many years' experience of using FU extraction method it seems that FOX grafts growing is worse compare to the common grafts created with dissection of the donor strip. We cannot find data's about survival of FOX grafts and therefore we attempted this single case bilaterally controlled study. Young patient with small (3 x 4 cm) postburn scar in fronto-parietal region was selected for the study. From donor area (midocciput) there were harvested grafts using both techniques: donor strip excision with subsequent stereo-microscopical dissection (107 FU-totally 176 follicles) and FU extraction using 0,95 mm punch (50 FU - totally 90 follicles). 107 recipient sites were created in the left and central area of the scar with N18 gauge Nokor needle and 107 common grafts were placed using jewelers forceps. 50 recipient sites were created in the right part of the scar and 50 FOX grafts were grafted. 5 month later the follicular survival was determined by counting terminal hair growth in these recipient sites. 94% follicular survival was obtained in the sites on the left and central side of the scar (common grafts) and 109% percent in the sites of the right side (FOX grafts). This study demonstrated that survival of the FOX grafts is equivalent to the survival of the common grafts created with dissection of the donor strip.
Adjuvant Chemotherapy for Stage II Colon Cancer: Less Complicated Than We Thought (2013)

In his recent editorial, Mayer 1 agreed with the conclusion of Tournigand et al 2 that there is no benefit for the inclusion of oxaliplatin in adjuvant chemotherapy regimens for patients with standard or indeed high-risk stage II colon cancer. Mayer then posed the question as to whether these patients, with a generally favorable prognosis, merit any adjuvant treatment at all. The virtues of prolonged clinical trial follow-up to provide mature survival data were extolled, but it surprised us greatly that no mention was made of Quasar (Quick and Simple and Reliable) 1 (A UKCCR[United Kingdom Coordinating Committee on Cancer Research] Study of Adjuvant Chemotherapy for Colorectal Cancer), the only trial in this field to show a survival benefit for patients with stage II colon cancer. In the Quasar 1 study, 2,291 patients with colon cancer were randomly assigned to receive chemotherapy with fluorouracil and leucovorin or to undergo observation. After a median follow-up of 5.5 years, the trial demonstrated that although the absolute improvements are small, the relative risk of death that was observed translates into a significant absolute improvement in survival of 3.6% (95% CI, 1.0 to 6.0; P .04). This is by far the largest and therefore the most informative trial of chemotherapy ever undertaken for this disease, and it is the only trial to show a significant survival benefit. 3 The fluorouracil-based chemotherapy was well tolerated, and we believe that these results are sufficient to mandate an informed discussion with all patients with stage II colon cancer so that at least the offer of treatment might be made. Furthermore, we have worked with colleagues from the National Surgical Adjuvant Breast and Bowel Project, the Cleveland Clinic, and Genomic Health to develop a polymerase chain reactionbased prognostic gene signature that has now been validated in more than 5,000 patients. This can be used to define the risk of recurrence with greater precision than conventionally accepted high-risk criteria, and therefore can inform and influence the outcome of the physicianpatient consultation. 4 We believe that there are data and validated tools that support rational and informed decision making on the utility of adjuvant fluorouracil-based therapy for patients with stage II colon cancer, and that matters are not necessarily as nihilistic as Mayer 1 implies.
Contamination of peripheral blood by monoclonal B cells following treatment of multiple myeloma by high‐dose chemotherapy (1993)

Peripheral blood samples obtained from five patients with multiple myeloma, after high-dose chemotherapy, were studied for monoclonal B plasma cell contamination. We used the technique of immunoglobulin heavy chain gene 'fingerprinting' at the time of diagnosis and during apheresis. The level of sensitivity of this technique is between 0.01% and 0.001% in two patients in whom a monoclonal population was detected in peripheral blood.
Lead-me interface for a pulling sensation from hand-held devices (2008)

When a small mass in a hand-held device oscillates along a single axis with asymmetric acceleration (strongly peaked in one direction and diffuse in the other), the holder typically experiences a kinesthetic illusion characterized by the sensation of being continuously pushed or pulled by the device. This effect was investigated because of its potential application to a hand-held, nongrounded, haptic device that can convey a sense of a continuous translational force in one direction, which is a key missing piece in haptic research. A 1 degree-of-freedom (DOF) haptic device based on a crank-slider mechanism was constructed. The device converts the constant rotation of an electric motor into the constrained movement of a small mass with asymmetric acceleration. The frequency that maximizes the perceived movement offered by the haptic device was investigated. Tests using three subjects showed that for the prototype, the best frequencies were 5 and 10 cycles per second.
State-Of-The-Art In The Matrix Stimulation Of Horizontal Wells (1996)

Abstract Horizontal wells have created a number of new challenges including the appropriate reservoir selection, drilling and completion techniques and, recently, stimulation. The ever lengthening horizontal sections pose considerable problems in fluid distribution, required stimulation fluid volumes and optimization of stimulation versus completion. The pre- and posttreatment productivity indexes, and stimulation execution requirements are the essential elements of the technology presented here.