gebhart/patrepeval huggingface dataset:
Epidermal sphingolipids: Metabolism, function, and roles in skin disorders (2006)

Mammalian epidermis produces and delivers large quantities of glucosylceramide and sphingomyelin precursors to stratum corneum extracellular domains, where they are hydrolyzed to corresponding ceramide species. This cycle of lipid precursor formation and subsequent hydrolysis represents a mechanism that protects the epidermis against potentially harmful effects of ceramide accumulation within nucleated cell layers. Prominent skin disorders, such as psoriasis and atopic dermatitis, have diminished epidermal ceramide levels, reflecting altered sphingolipid metabolism, that may contribute to disease severity/progression. Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review.
Response of RC Shear Wall under Ground Motions (1981)

The formulation is presented of an analytical model using the finite element technique to compute the nonlinear dynamic behavior of reinforced concrete planar structures under earthquakes. The model is based on a lumped-mass approach, and utilizes the Newmark β-method to perform the step-by-step integration of the equations of motion. This model is applied to trace the response of a three story shear-wall subject to the El Centro earthquake of May 1940. The results computed are compared with an experimental investigation.
Reference Submodule Based Capacitor Monitoring Strategy for Modular Multilevel Converters (2018)

The modular multilevel converter (MMC) is attractive for medium- or high-power applications because of the advantages of its high modularity, availability, and high power quality. Reliability is one of the most important challenges for the MMC consisting of a large number of submodules (SMs). The capacitor monitoring is one of the important issues in the MMC. This paper proposed a reference submodule (RSM)-based capacitor monitoring strategy for the capacitance estimation in the MMC, where the capacitances in the monitoring SMs can be estimated based on the capacitor voltage relationship between the RSM and the monitoring SMs. The proposed monitoring strategy does not rely on the information of all capacitor voltage and current, which effectively simplifies the algorithm for capacitance estimation. The simulation studies with the time-domain professional tool PSCAD/EMTDC are conducted and a down-scale MMC prototype is also tested in the laboratory with the proposed capacitor monitoring strategy. The study results confirm the effectiveness of the proposed capacitor monitoring strategy.
An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis (1995)

We have analyzed the distribution of tumor necrosis factor (TNF) a and -b microsatellite alleles in HLA-DQ and -DR typed Swedish patients with multiple sclerosis (MS) (n = 122) and ethnically matched control subjects (n = 178). We found significant differences in the frequencies of TNFa and TNFb alleles between patients and controls. TNFaII was significantly associated with MS. This was also the case for the combination of TNFaII with TNFb4. However, TNFaII (alone or in combination with TNFb4) did not show any disease association independent of DQA1*0102/ DQB1*0602/DR2, whereas the previously reported strong association with HLA-DQA1*0102/DQB1*0602/DR2 in Scandinavian populations was confirmed. Therefore the association of TNFaII (and TNFb4) is most likely secondary to the increase of DQA1*0102/DQB1*0602/DR2 in MS patients. The proportion of TNFa6 positive individuals was lower among DR2-negative MS patients than among DR2-negative controls (P = 0.08). Since the presence of the TNFa6 allele correlates with low TNF alpha production in response to lipopolysaccharide, it could be speculated that DR2-negative MS patients have an increased risk of being high TNF alpha producers in response to exogenous stimuli.
Value of prognostic nutritional index for survival prediction in trans-catheter aortic valve replacement compared to other common nutritional indexes (2020)

PNI is a useful and practical nutritional marker reflecting malnutrition and inflammation prior to the intervention, and strongly predicts 1-year survival. PNI seems to be a better prognostic marker than BMI or GNRI after TAVR.
Challenges for global supply chains and opportunities for social innovation (2019)

Supply chains have become increasingly dispersed to the extent that some of the most popular products on the market are sold by companies that barely engage in the manufacturing process. Dispersed supply chains limit firms’ ability to monitor and control critical processes, thus creating many challenges around sustainability and social responsibility, such as detecting the identity of suppliers or implementing sustainability policies along their supply chains. Presently, the main themes of research on supply chain management are efficiency, coordination, and reliability. As for organization theory and strategy research, the main research topics include the economics of supply chains, the environmental and social consequences of outsourcing, and the consequences of regularity arbitrage and competition. The core problem for effectively implementing global supply chain social innovation is visualizing supply chains. Furthermore, the pressure to advance firms’ ability to fully understand their production process and vet their globally dispersed supply chains can come from various sources: regulatory actions, consumer demands, voluntary coordination among industry participants, activism by social entrepreneurs, employee pressures, and shareholder pressures. Avenues for global supply chain social innovations abound. The authors offer some promising directions for future research, such as investigating the implications for entrepreneurial opportunities that put improving supply chain visibility at the core of their business model, the interplay between different social innovators in the supply chain context, and the viability and compatibility of “going local” with global outsourcing.
Reliable Methods for Alignment of LC Polymer (1990)

Abstract Magnetic field and alternating shear were used to align a LC polymer.
Effect of iron-binding polypeptides and non-starch polysaccharides supplementation on growth performance and fecal scores of weaning pigs (2022)

Background: Weaning is the most stressful event in pig’s life, resulting in postweaning diarrhea and growth retardation. The supplementation of Advanced Digestion Enhancing Protein Plus Technology (ADEPPTTM), which contains iron-binding polypeptides and non-starch polysaccharides, to nursery diets may reduce the occurrence of diarrhea and enhance growth performance of weaning pigs. Objective: To evaluate the effect of ADEPPTTM supplementation on growth performance and fecal score in weaning pigs. Methods: At weaning, a total of 54 weaning pigs (initial body weight: 7.42 ± 0.52 kg) were assigned to 3 treatments in 3 replicates with 6 pigs per pen based on sex, breed, and body weight for a 28-d feeding trial. The pigs were fed corn-soybean meal-based diets containing 0.0, 0.5, and 1.0% of the ADEPPTTM product in 2 phases (d 0-14 and d 15-28 postweaning, respectively). In the first week (d 3-5 postweaning) of the trial, a pig was removed from each pen when diarrhea was observed, housed in a separate pen within treatment, and then treated for 3 days with a 100-ml solution of electrolytes and ADEPPTTM by drenching. Growth performance and fecal score (1=normal to 4=watery diarrhea) were measured. Results: In the feeding trial, there were no significant differences in body weight, average daily gain, and average daily feed intake throughout the overall period. However, a quadratic trend was observed in gain to feed ratio (p=0.09) for d 0-7 postweaning and overall period with increasing ADEPPTTM supplementation levels in which the greatest value was observed in the 0.5% ADEPPTTM level. The fecal score tended to decrease linearly with increasing ADEPPTTM levels during d 0-7 (p=0.11) and 0-14 (p=0.12) postweaning. There was no significant difference on fecal score of diarrheic pigs and average daily gain tended to increase linearly in d 21-28 postweaning (p=0.08) with increasing ADEPPTTM levels. Conclusion: These results indicate that 0.5% ADEPPTTM supplementation has a potential to enhance growth performance of weaning pigs and might be effective to prevent and control postweaning diarrhea.
Design of Planar and Conformal, Passive, Loss-less Metasurfaces that Beamform (2021)

A general technique for synthesizing both planar and conformal beamforming metasurfaces is presented that utilizes full-wave modeling techniques and rapid optimization methods. The synthesized metasurfaces consist of a patterned metallic cladding supported by a finite-size grounded dielectric substrate. The metasurfaces are modeled using integral equations which accurately account for mutual coupling and the metasurface's finite dimensions. The synthesis technique consists of three phases: a direct solve phase to obtain an initial metasurface design with complex-valued impedances satisfying the desired far-field beam specifications, a subsequent optimization phase that converts the complex-valued impedances to purely reactive ones, and a final patterning phase to realize the purely reactive impedances as a patterned metallic cladding. The optimization phase introduces surface waves which facilitate passivity. The metasurface is optimized using gradient descent with a semi-analytic gradient obtained using the adjoint variable method. Three examples are presented: a low-profile directly-fed metasurface antenna with near perfect aperture efficiency, a scanned-beam reflectarray design with controlled sidelobes, and a conformal metasurface reflectarray. The far-field and near-field performance of the metasurfaces are verified and the bandwidth and loss tolerance of the metasurfaces are investigated.
Supporting Adaptive Services in a Heterogeneous Mobile Environment (1994)

Future computer environments will include mobile computers which will eiUler be disconnected, weakly interconnected by low speed wireless networks such as GSM, or fully inter-connected by high speed networks ranging from Ethernet to ATM. While the transition between networks is currently a heavyweight operation we believe that developments in network interface technology will soon enable mobile computers to dynamically select their network service based on cost and performance requirements. Such flexibility, coupled with tile inherent unreliability of mobile communications, means that system services and applications will be subject to rapid and massive fluctuations in tile quality-of-service provided by their underlying communications infrastructure. In this paper we discuss the design of a distributed systems platform to support tile development of services which are able to tolerate this environment by dynamically adapting to changes in tile available communications quality-of-service.
Inactivation of Endothelial Small/Intermediate Conductance of Calcium‐Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients (2015)

Diabetes is associated with inactivation of endothelial SK(Ca)/IK(Ca) channels, which may contribute to endothelial dysfunction in diabetic patients.
Reactivation of systemic lupus erythematosus in a dialysis patient after tuberculous peritonitis (2002)

The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We report a case of a 43-year-old Chinese woman on long-term peritoneal dialysis, who developed lupus reactivation with cerebral involvement 2 weeks after she was diagnosed to have tuberculous peritonitis. The close temporal relationship between the tuberculous peritonitis and the lupus reactivation raise the possibility that the tuberculous infection might have triggered off the lupus reactivation.
Mobile robot for overhead powerline inspection and a controlling method for obstacle avoidance (2011)

This paper designs a mobile robot for overhead powerline inspection and a controlling method for obstacle avoidance, which is composed of three suspender arm with the three-coordinate rolling wheel machine, three-node CAN bus system and wireless image transmission with CCD. The suspender arm includes the straight line synchro-strap rail bar for mobile in breadth, the gear-rack machine for moving horizontally, the synchro-strap rail bar for moving vertically and the driving machine with a rolling wheel. Every suspender arm can move in three right-angle coordinate direction through the motor with a photoelectric coder,in which the sensors are built for the purpose of detecting the obstacles such as the quakeproof bar, line clamp and down-lead etc. The controlling system can realizes the whole robot machine rolls along the powerline in a long distance and avoids obstacles automatically by driving relevant motor for suspender arm's three-coordinate moving based for program after analyzing the inputting sensors' signal including the sensors for detecting the obstacles and photoelectric coders.
Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment (2012)

Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways involving ATR, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. Cisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway. In addition, a new mechanism has recently been revealed, in which the oncoprotein c-Myc suppresses bridging integrator 1 (BIN1), thereby releasing poly(ADP-ribose)polymerase 1, which results in increased DNA repair activity and allows cancer cells to acquire cisplatin resistance. The present paper focuses on the molecular mechanisms of cisplatin-induced apoptosis and of cisplatin resistance, in particular on the involvement of BIN1 in the maintenance of cisplatin sensitivity.
Expression and regulation of glycoprotein C gene of herpes simplex virus 1 resident in a clonal L-cell line (1986)

Ltk- cells were transfected with a plasmid containing the entire domain of glycoprotein C (gC), a true gamma or gamma 2 gene of herpes simplex virus 1 (HSV-1) and the methotrexate-resistant mouse dihydrofolate reductase mutant gene. The resulting methotrexate-resistant cell line was cloned; of the 39 clonal lines tested only 1, L3153(28), expressed gC after infection with HSV-1(MP), a gC- mutant, and none expressed gC constitutively. The induction of gC was optimal at multiplicities ranging between 0.5 and 2 PFU per cell, and the quantities produced were equivalent to or higher than those made by methotrexate-resistant gC- L cells infected with wild-type (gC+) virus. The gC gene resident in the L3153(28) cells was regulated as a beta gene inasmuch as the amounts of gC made in infected L3153(28) cells exposed to concentrations of phosphonoacetate that inhibited viral DNA synthesis were higher than those made in the absence of the drug, gC was induced at both permissive and nonpermissive temperatures by the DNA- mutant tsHA1 carrying a lesion in the gene specifying the major DNA-binding protein and which does not express gamma 2 genes at the nonpermissive temperature, and gC was induced only at the permissive temperature in cells infected with ts502 containing a mutation in the alpha 4 gene. The gC induced in L3153(28) cells was made earlier and processed faster to the mature form than that induced in a gC- clone of methotrexate-resistant cells infected with wild-type virus. Unlike virus stocks made in gC- cells, HSV-1(MP) made in L3153(28) cells was susceptible to neutralization by anti-gC monoclonal antibody.
Role for Bcl-xLas an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis (1997)

Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-xL fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stress. Coimmunoprecipitation studies demonstrate that Bcl-xL associates with cytochrome C. Cytochrome C binds directly and specifically to Bcl-xL and not to the proapoptotic Bcl-xs protein. The results also demonstrate that Bcl-xs blocks binding of cytochrome C to Bcl-xL. Our findings support a role for Bcl-xL in protecting cells from apoptosis by inhibiting the availability of cytochrome C in the cytosol.
Data Files on the Chi-Chi Earthquake from the Central Mountain Strong-Motion Array (2004)

The Central Mountain strong-motion array is operated by the Institute of Earth Science, Academia Sinica. The Central Mountain ranges are the high mountainous region of Taiwan, with peaks up to 4000 m. There are only a few roads, and access is difficult in general. We installed these stations for the following reasons:



1. To understand the attenuation effect of ground motion across the Central Mountain ranges to compare it with records obtained by the CWB stations that are almost entirely in the plain areas where people live.

2. To study topographic effects of ground motions in mountainous area.

3. To understand the characteristics of strong-motion data in mountainous areas, which may be …
Significance of prognostic prediction and cost-benefit-analysis in intensive therapy in fulminant hepatitis. (1998)

最近3年間に当施設で経験した劇症肝炎12例の総医療費について調べ, さらに予後予測と実際の予後との見直しを行い, 予後判定の有用性の有無や社会的問題点などについて検討した. 非A非B非C型の劇症肝炎亜急性型の8例はすべて死亡した. 予後予測による予後判定では, 高橋らのLogistic analysisおよび肝移植適応ガイドライン案では全例に転帰の一致をみた. 60日以上延命できたが肝不全のために死亡した亜急性型の3症例では, 総医療費も膨大となった. 平均15日の治療期間で, 1日あたりの医療費が40万円を超える例が5例 (42%) に認められた. 劇症肝炎の集中治療においては, 1カ月に約1000万の医療費が必要と考えられた. 以上より劇症肝炎亜急性型で死亡が予測された症例では, 早期に肝移植を考慮すべきであり, 十分なインフォームドコンセントのもとに家族の同意を得た治療法を選択する必要がある.
Model for selective targeting of DNA Ligase I and III to DNA replication and different repair pathways (2011)

<b>Copyright information:</b>Taken from "Differential recruitment of DNA Ligase I and III to DNA repair sites"Nucleic Acids Research 2006;34(12):3523-3532.Published online 19 Jul 2006PMCID:PMC1524911.© 2006 The Author(s) All DNA Ligases use the same catalytic mechanism and show high sequence similarity in the catalytic core (grey shading). The active site lysine residue (K) in the center of the catalytic domain is directly involved in the ligation reaction. However, DNA Ligases have non-overlapping functions in DNA repair and replication and are not interchangeable. We could show that DNA Ligase I and III are targeted to different repair pathways through their regulatory PBD and BRCT domains which mediate interaction with PCNA and XRCC1, respectively. This selective recruitment of specialized DNA Ligases may accommodate the specific requirements of different repair pathways and thereby enhance repair efficiency.
A Total Absorption Ge(Li) Gamma Ray Spectrometer (1968)

A configuration of a large Ge(Li) detector has been developed which suppresses single, local interactions, particularly Compton scatterings. The peripheral n+ contact of a coaxial detector is split into two or more segments, and events are recorded from the central p contact if signals are coincidentally present on two segments of the n+ contact. A sum signal is derived from the central p contact through a high resolution preamplifier, and individual localization signals are taken from each segment of the n+ contact through simple voltage-sensitive preamplifiers. The maximum sensitivity of the system lies between 300 and 1300 keV where the Compton crosssection is dominant and many Compton scattered γ-rays are not sufficiently energetic to escape. The total absorption mode achieves about 20% of the photopeak efficiency of the detector operated in the normal singles mode. An increase in the ratio of the full energy peaks to the Compton continuum of 10:1 is found for 60Co γ-rays, and it is significantly greater for γ-rays of less than 1 MeV. The use of internal detector summing of the linear signal eliminates the need for complicated external preamplifier gain adjustment and stability. Capacitively coupled, voltage-sensitive preamps on each n+ segment add negligible noise and reduce the sum signal-to-noise ratio only to the extent that the input shunt capacitance used reduces the sum signal level by about 10%. Thus, a 30 cc split n+ detector yields 3.9 keV 60Co resolution in the coincidence mode compared with 3.5 keV when both n+ segments are grounded.
Homogenized Magnetic Properties of Heterogeneous Anisotropic Structures Including Nonlinear Media (2009)

In this paper, a mathematical homogenization technique is applied to the analysis of soft magnetic composites where ferromagnetic particles are dispersed within an insulating medium. The effective magnetic properties are evaluated for different inclusion shapes, assuming isotropic nonlinear/hysteretic characteristics for the ferromagnetic inclusions. The results show the effect of shape anisotropies, due to the material microstructure, on the overall behavior of the composite.
Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro (2008)

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.
Enteric defensins: antibiotic peptide components of intestinal host defense. (1992)

Five intestinal defensins, termed cryptdins 1-5, have been purified from mouse small bowel, sequenced, and localized to the epithelium by immunohistochemistry. Although identified as members of the defensin peptide family by peptide sequencing, enteric defensins are novel in that four cryptdins have amino termini which are three to six residues longer than those of leukocyte-derived defensins. A fifth cryptdin is the first defensin to diverge from the previously invariant spacing of cysteines in the peptide structure. The most abundant enteric defensin, cryptdin-1, had antimicrobial activity against an attenuated phoP mutant of Salmonella typhimurium but was not active against the virulent wild-type parent. Immunohistochemical localization demonstrated that cryptdin-1, and probably cryptdins 2 and 3, occur exclusively in Paneth cells, where the peptides appear to be associated with cytoplasmic granules. Biochemical and immunologic analysis of the luminal contents of the small intestine suggest that cryptdin peptides are secreted into the lumen, similar to Paneth cell secretion of lysozyme. The presence of several enteric defensins in the intestinal epithelium, evidence of their presence in the lumen, and the antibacterial activity of cryptdin-1 suggest that these peptides contribute to the antimicrobial barrier function of the small bowel mucosa.