gebhart/patrepeval huggingface dataset:
Data Streams: Algorithms and Applications (2005)

Data stream algorithms as an active research agenda emerged only over the past few years, even though the concept of making few passes over the data for performing computations has been around since the early days of Automata Theory. The data stream agenda now pervades many branches of Computer Science including databases, networking, knowledge discovery and data mining, and hardware systems. Industry is in synch too, with Data Stream Management Systems (DSMSs) and special hardware to deal with data speeds. Even beyond Computer Science, data stream concerns are emerging in physics, atmospheric science and statistics. Data Streams: Algorithms and Applications focuses on the algorithmic foundations of data streaming. In the data stream scenario, input arrives very rapidly and there is limited memory to store the input. Algorithms have to work with one or few passes over the data, space less than linear in the input size or time significantly less than the input size. In the past few years, a new theory has emerged for reasoning about algorithms that work within these constraints on space, time and number of passes. Some of the methods rely on metric embeddings, pseudo-random computations, sparse approximation theory and communication complexity. The applications for this scenario include IP network traffic analysis, mining text message streams and processing massive data sets in general. Data Streams: Algorithms and Applications surveys the emerging area of algorithms for processing data streams and associated applications. An extensive bibliography with over 200 entries points the reader to further resources for exploration.
Group 5 Imido Complexes Supported by Diamido−pyridine Ligands:  Aryloxide, Amide, Benzamidinate, Alkyl, and Cyclopentadienyl Derivatives (2001)

A family of new organometallic and coordination group 5 compounds supported by an imido−diamido−pyridine ligand set are reported. Reaction of [M(NR)Cl(κ3-N2Npy)(py)] (M = Nb, R = tBu 1; M = Ta, R = tBu 2 or Ar 3, where N2Npy = MeC(2-C5H4N)(CH2NSiMe3)2 and Ar = 2,6-C6H3iPr2) with LiOAr or LiPhC(NSiMe3)2 afforded the five-coordinate aryloxide and benzamidinate complexes [M(NR)(OAr)(κ3-N2Npy)] (R = tBu, M = Nb 4 or Ta 5; R = Ar, M = Ta 6) and [Nb(NtBu){PhC(NSiMe3)2}(κ3-N2Npy)] (7), respectively. Reaction of 1 or 2 with LiN(SiMe3)2 or LiCH(SiMe3)2 gave the four-coordinate compounds [M(NtBu)(X)(κ2-N2Npy)] (M = Nb, X = N(SiMe3)2 8 or CH(SiMe3)2 9; M = Ta, X = CH(SiMe3)2 10). Reaction of 1 or 2 with the less sterically demanding alkyl reagent LiCH2SiMe3 gave, in the case of niobium, only the four-coordinate [M(NtBu)(CH2SiMe3)(κ2-N2Npy)] (11), but for tantalum an equilibrium mixture of four- (κ2-) and five- (κ3-) coordinate isomers was identified by NMR spectroscopy. Reaction of 1 with PhCH2MgCl or LiC5H4Me gave the corresponding η1- or η5-hydrocarbyl complexes [Nb(NtBu)(CH2Ph)(κ3-N2Npy)(py)] (13) and [Nb(NtBu)(η5-C5H4Me)(κ2-N2Npy)] (14). The X-ray crystal structures of the compounds 4, 6, and 9 are reported.
Removal of heavy metals from water and brine using silicon alloys (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemoval of heavy metals from water and brine using silicon alloysJames P. McKaveney, William P. Fassinger, and David A. StiversCite this: Environ. Sci. Technol. 1972, 6, 13, 1109–1113Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://doi.org/10.1021/es60072a008Request reuse permissionsArticle Views235Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (599 KB) Get e-Alertsclose Get e-Alerts
Cetuximab plus radiochemotherapy in locally advanced anal cancer: Interim results of the French multicenter phase II trial ACCORD16. (2011)

4098 Background: The combination of radiotherapy and chemotherapy is a mainstay for anal cancer. Improving local control could avoid mutilating salvage. We evaluate the role of an intensified strategy combining radio-chemotherapy with 5FU-cisplatinum and cetuximab for locally advanced anal cancer in the setting of a multicentric phase II trial. Methods: This study aimed to evaluate the response rate after radiotherapy and a concurrent 5FU-cisplatinum regimen combined to cetuximab. Patients (pts) with locally advanced anal cancer treated by radiotherapy combined to cisplatinum, 5FU and cetuximab. The primary end-point was local response rate 2 months after therapy. Secondary endpoints were progression-free survival, overall survival, colostomy-free survival and safety. A two-step design was used. Results: Between 03/09 and 05/10, 16 patients were included in 7 centers. All patients presented locally advanced tumors (5 extended to the vagina, 1 to the bladder). All were squamous cell carcinoma. Only 8 pts receive both the 6 cetuximab administrations and the two 5FU-cisplatinum cycles. Accrual was suspended after 10 pts after the occurrence of 10 serious adverse events (SAE) in 7 patients of which 6 SUSAR. The protocol was amended : decrease the 5FU and the cisplatinum dose, mandatory IMRT. After accrual of 6 additional pts, 6 SAE in 5 pts. Severe toxicities were: lymphopenia (8 pts), diarrhea (6 pts), fatigue (6 pts), neutropenia (5 pts), acneiform rash (4 pts), thrombopenia (4 pts), hypoNa or K (4 pts); radioepithelitis 3 pts. 3 pts had severe toxicity between 3-6 months follow-up: radio-necrosis pelviperineal (1 pts); mucitis and acneiform rash (1 pts); febrile syndrome (1 pts). After exclusion of the 3 pts with early withdrawal and with a 14 months median follow-up, median PFS is 9 months and one-year survival rate 91%. (local failure (4 pts), metastasis (1 pts). 4 patients had colostomy (2 for local relapse, 2 for fistulisation). Conclusions: The IDMC decided to stop the trial after the first 16 patients for a high rate of toxicity and an insufficient efficacy. This regimen is not recommended combined with RT even in case of locally advanced disease.
Photocontrol of the Hv1 Proton Channel (2017)

The voltage-gated proton channel Hv1 is expressed in various human cell types, including macrophages, epithelial cells, and sperm. Hv1 opening leads to proton efflux that alkalizes the cytosol. Here, we describe light-activated Hv1 inhibitors (photoswitches) that allow controlling its activity with high spatiotemporal precision. The photoswitches comprise a light-sensitive azobenzene moiety and 2-guanidinobenzimidazole (2GBI), a known Hv1 inhibitor. In the dark, photoGBI inhibits heterologously expressed Hv1 channels. Blue light, which isomerizes the azobenzene group from trans to cis conformation, releases inhibition. We demonstrate photocontrol of native proton currents in human macrophages and sperm using photoGBI, underlining their use as valuable optochemical tools to study the function of Hv1 channels.
Application of High Sampling Rate Downhole Measurements for Analysis and Cure of Stick-Slip in Drilling (1994)

Abstract Optimal control of the drilling process requires that relevant physical models must be used while drilling. The reliability of these models must first be improved by comparing their results with actual downhole and surface data. Measurements of numerous drilling parameters and variables, sampled at high frequency, are then required. Trafor is an MWD system designed and operated by the Institut Français du Pétrole for research on drill-string dynamics. It measures 15 downhole and 5 surface mechanical parameters. Because Trafor is fitted with an electric link adapted to rotary drilling, it transmits the downhole measurements to the surface in real time with a very high sampling rate of 1800 measurements per second. Furthermore, all the signals are fully synchronized. Hence, Trafor allows cross analysis between any signals, regardless of whether they are from downhole or from the surface. New data recorded in a 1060 m deep well exhibit stick-slip behavior for various weights-ön-bit and rotary speeds. Downhole data analysis coupled with numerical simulations shows that, in this field case, stick-slip occurred as an unstable drilling process. The origin of the instability lies in the relationship between the torque at the bit and the rotary speed. From this relationship, we can explain why stick-slip is known to disappear whenever the rotary speed (rpm) is increased or weight-on-bit is decreased. A stability analysis is used to derive operating conditions that prevent stick-slip. Simulations of drilling with adjusted PID or with a downhole "anti stiçk-slip" tool are described. For both simulations, stick-slip can be cured.
Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish (2023)

The combination drug regimens that have long been used to treat tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i>, are fraught with problems such as frequent administration, long duration of treatment, and harsh adverse effects, leading to the emergence of multidrug resistance. Moreover, there is no effective preventive vaccine against TB infection. In this context, nanoparticles (NPs) have emerged as a potential alternative method for drug delivery. Encapsulating antibiotics in biodegradable NPs has been shown to provide effective therapy and reduced toxicity against <i>M. tuberculosis</i> in different mammalian models, when compared to conventional free drug administration. Here, we evaluate the localization, therapeutic efficacy and toxic effects of polymeric micellar NPs encapsulating a promising but highly hydrophobic and toxic antitubercular drug bedaquiline (BQ) in zebrafish embryos infected with <i>Mycobacterium marinum.</i> Our study shows that the NP formulation of BQ improves survival and reduces bacterial burden in the infected embryos after treatment when compared to its free form. The intravenously injected BQ NPs have short circulation times due to their rapid and efficient uptake into the endothelial cells, as observed by correlative light and electron microscopy (CLEM).
Plasma Membrane Fluidity Affects Transient Immobilization of Oxidized Phospholipids in Endocytotic Sites for Subsequent Uptake (2008)

Oxidized phospholipids in serum initiate severe pathophysiological responses during the process of atherogenesis. On the cellular level it is known that these lipids induce apoptosis; however, the uptake mechanism remains enigmatic. We investigated here the behavior of the fluorescent oxidized phospholipid 1-palmitoyl-2-glutaroyl-sn-glycero-3-phospho-N-Alexa647-ethanolamine (PGPE-Alexa647) in the plasma membrane of various cell lines. The probe was taken up by the cells unspecifically via caveolae or clathrin-coated pits. Interestingly, we found the uptake to be facilitated by the overexpression of the scavenger receptor class B type I. Ultra-sensitive microscopy allowed us to follow the uptake process at the single molecule level; we observed rapid diffusion of PGPE-Alexa647 in the plasma membrane, interrupted by transient halts with duration of approximately 0.9 s at endocytotic sites. Scavenger receptor class B type I overexpression yielded a pronounced increase in the single molecule mobility, and in consequence an increased frequency of immobilization. Alternatively, the plasma membrane fluidity could also be increased by treating cells with high levels of the unlabeled oxidized phospholipid 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine; also in this case, the immobilization frequency of PGPE-Alexa647 was concomitantly increased. The data demonstrate the relevance of plasma membrane properties for uptake of oxidized phospholipids, and indicate a novel indirect mechanism for the control of endocytosis.
Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo. (1996)

Earlier work from this laboratory showed that the human proteoglycan aggrecan from fetal cartilages can induce a CD4+ T cell-dependent inflammatory polyarthritis in BALB/c mice when injected after removal of chondroitin sulfate chains. Adult keratan sulfate (KS)-rich aggrecan does not possess this property. We found that two CD4+ T cell hybridomas (TH5 and TH14) isolated from arthritic mice recognize bovine calf aggrecan and the purified G1 domain of this molecule, which also contains a portion of the interglobular domain to which KS is bound. These hybridoma responses to G1 are enhanced by partial removal of KS by the endoglycosidase keratanase or by cyanogen bromide cleavage of core protein. KS removal results in increased cellular uptake by antigen-present cells in vitro. After removal of KS by keratanase, G1 alone can induce a severe erosive polyarthritis and spondylitis in BALB/c mice identifying it as an arthritogenic domain of aggrecan. The presence of KS prevents induction of arthritis presumably as a result of an impaired immune response as observed in vitro. These observations not only identify the arthritogenic properties of G1 but they also point to the importance of glycosylation and proteolysis in determining the arthritogenicity of aggrecan and fragments thereof.
Photometric studies of five eclipsing binaries: RS Ser, V0449 Per, MR Del, V593 Cen, and V1095 Her (2021)

ABSTRACT RS Ser, V449 Per, MR Del, V593 Cen, and V1095 Her are short-period eclipsing binaries. We made photometric observations on 38 nights using four 1-m-class telescopes and plotted eight light curves. We determined the spectral type of V449 Per as K0(±2)V using low-resolution spectra from the Lijiang 2.4-m telescope. We found cyclic variation in the orbital periods for RS Ser and V1095 Her, and confirmed the cyclic variation of MR Del. The periods of the hypothetical third bodies are close to the duration of observation, and the detected cycles are questionable. For V593 Cen, we followed the previously published suggestion that it probably has a black hole with a minimum mass of 3.68 M⊙. We used the orbital period decreasing at a rate of 8.2(0.1) × 10−8 d yr–1 to explain it. There are two alternative interpretations, and hence the black hole candidate of V593 Cen remains questionable because the minimum points are concentrated in four clusters. The period of V449 Per increases continuously at a rate of 9.5 × 10−8 d yr–1, which can be attributed to mass transfer from the less massive component to the more massive component. For MR Del, we used a new light curve and the published radial velocity to revise its absolute parameters. Furthermore, we revised the photometric solution of V593 Cen and confirmed it as an early-type contact binary with a higher contact factor. We obtained preliminary photometric parameters for RS Ser, V1095 Her, and V449 Per.
Relationship Between Foot Flexibility and Urinary Incontinence in Nulliparous Varsity Athletes (1996)

How impact forces are absorbed may be one potential etiology for stress incontinence. An improved understanding of how impact forces are transmitted to the pelvic floor could provide important information about potential preventive interventions for urinary incontinence and other pelvic floor disorders, such as genital prolapse.
Nonparametric Bayesian Logic (2012)

The Bayesian Logic (BLOG) language was recently developed for defining first-order probability models over worlds with unknown numbers of objects. It handles important problems in AI, including data association and population estimation. This paper extends BLOG by adopting generative processes over function spaces - known as nonparametrics in the Bayesian literature. We introduce syntax for reasoning about arbitrary collections of objects, and their properties, in an intuitive manner. By exploiting exchangeability, distributions over unknown objects and their attributes are cast as Dirichlet processes, which resolve difficulties in model selection and inference caused by varying numbers of objects. We demonstrate these concepts with application to citation matching.
Spot-blot hybridization assay for the detection of hepatitis b virus dna in serum: Factors determining its sensitivity and specificity (1987)

Factors determining the sensitivity and specificity of the spot-blot hybridization technique for the detection of hepatitis B virus DNA in serum were systematically investigated. Methods for pretreatment of serum samples, mode of application of the samples to the transfer membranes, blot treatment and hybridization conditions were all found to affect the sensitivity of the assay. The optimum hybridization procedure was found to be incubation of serum samples with salt, NaOH, formaldehyde and detergent, followed by spot application of the samples. This method specifically detected hepatitis B virus DNA in serum with a sensitivity 5 to 15 times higher than the presently used assay procedures.
Eating, sleeping and rewarding: orexin receptors and their antagonists. (2006)

The orexin system plays a key role in the control of eating, sleeping and rewarding. This review summarizes the latest developments in the identification of orexin receptor antagonists. By using a selective orexin-1 receptor antagonist, SB-334867-A (GlaxoSnzithKline plc), the in vivo futctions of both the orexin-1 and orexin-2 receptors have been elucidated. This review also sunmmarizes the literature and current opinions up to May 2006 on the therapeutic utility of orexin receptor antagonists for the treatment of eating disorders, sleeping disorders and drug addiction.
Clinical experience in continuous graft monitoring with microdialysis early after liver transplantation (2002)

Microdialysis allows continuous monitoring of tissue metabolism in the transplanted liver. The procedure is easy to perform and safe. The specific detection and monitoring of pathological changes in the liver graft (e.g. arterial and portal vein thrombosis, or early rejection) with microdialysis should be addressed in further studies.
Comparisons of Laboratory Tests and Simple Clinical Tests for Identifying Fallers among Healthy Older Persons (2011)

Reduced postural control and related falls are a major cause of injury and death in older individuals. PURPOSE: To examine the capacity of a number of field and laboratory tests to identify fallers in a sample of older independently-living persons. METHODS: 66 healthy, independently-living older volunteers, ages 60 and older made three laboratory visits during which field tests (Timed Up and Go [TUG], One-Leg Stand [OLS], Functional Reach [FR], and Tinetti Performance Oriented Mobility Assessment [POMA]) and laboratory-based tests (force plate center of pressure [COP] and time-to-boundary [TTB], and dynamic posturography [Proprio 5000]) were compared to ascertain the capacities of these tests to distinguish fallers from non-fallers. Each participant was classified as a "faller" or "non-faller" based on whether he or she recalled experiencing a fall within the past year. RESULTS: Receiver-operated characteristics (ROC) curve analyses revealed the OLS and TUG had the capacity to distinguish fallers from non-fallers (P=0.002 and 0.008, respectively) as did selected Proprio 5000 and TTB variables (P<.015 and P<.042, respectively). One-way ANOVA results reflected ROC analyses with significant between-group differences for the OLS (P=0.002), TUG (P= 0.008), POMA (P<0.044), Proprio 5000 (P<.013) and TTB (P<.047). For the field tests, the OLS and TUG showed the largest effect sizes (0.93 and 0.79, respectively), while for laboratory tests, the Proprio 5000 revealed the largest effect sizes ranging from.73 to.88 depending on the plane of motion evaluated. CONCLUSION: Selected field and laboratory tests have the capacity to identify fallers in a healthy, independent-living sample of older persons. In addition, the laboratory tests revealed balance decrements in specific planes of motion that can provide more detailed information concerning directional falls risk. When examining the directional planes specifically, the rotational rather than translational variables were indicative of fallers. Unlike results previously reported for younger subjects with better balance than their contemporaries, high rotational scores were produced by non-fallers perhaps indicating increased degrees of freedom, as they employed multi-joint and multi-directional balance recovery strategies.
Identification of individual root-knot nematodes using low coverage long-read sequencing (2021)

Root-knot nematodes (RKN; genus Meloidogyne) are polyphagous plant pathogens of great economic importance to agriculturalists globally. These species are small, diverse, and can be challenging for accurate taxonomic identification. Many of the most important crop pests confound analysis with simple genetic marker loci as they are polyploids of likely hybrid origin. Here we take a low-coverage, long-read genome sequencing approach to characterisation of individual root-knot nematodes. We demonstrate library preparation for Oxford Nanopore Technologies Flongle sequencing of low input DNA from individual juveniles and immature females, multiplexing up to twelve samples per flow cell. Taxonomic identification with Kraken 2 (a k-mer-based taxonomic assignment tool) is shown to reliably identify individual nematodes to species level, even within the very closely related Meloidogyne incognita group. Our approach forms a robust, low-cost, and scalable method for accurate RKN species diagnostics.
Abstract 19152: Increased Extracellular Nucleosome Levels, Biomarkers of Cell Death, in Atrial Fibrillation Patients Compared to the Normal Population (2016)

Introduction: Atrial fibrillation (AF) is currently the most common cardiac arrhythmia encountered in clinical practice and a major cause of morbidity and mortality among adults. It is estimated that atrial fibrillation affects approximately 2.7 million people in the United States. Extracellular plasma nucleosomes (PNs) are complexes of DNA and histones that are released during cell death. Histones have been shown to function as DAMPs when they are translocated from the nucleus to the extracellular space. These nucleosomes mediate inflammatory and thromobotic responses and could serve as biomarkers in atrial fibrillation. Methods: The concentration of PNs in plasma samples of atrial fibrillation patients (n=43), aged normals (n=35), and young normals (n=29) were measured using the Cell Death Detection ELISA PLUS assay (Roche Diagnostics, Mannheim, Germany). For this study, the baseline plasma samples of atrial fibrillation patients were analyzed. Results: In comparison to the plasma from aged normals (11.42 ± 9.15 Arbitrary Units (AU)) and young normals (6.42 ± 0.87 AU; p Conclusion: PNs were elevated in atrial fibrillation when compared to both aged and young normals, indicating an increased release of nucleosomes, suggesting increased cell death. Extracellular nucleosomes function as DAMPs by binding to receptors and triggering the activation of multiple signal pathways. Due to the involvement of inflammation and thrombosis in the pathology of atrial fibrillation, the increased circulating nucleosome level in patients with atrial fibrillation implies that PNs may activate the immune system and generate the inflammatory response. These results suggest that PNs may serve as a biomarker in atrial fibrillation.