gebhart/patrepeval huggingface dataset:
Möglichkeiten der drahtlosen Biosignalerfassung mittels digitaler Speicherung - Possibilities of Wireless Recording of Biosignals by Means of Digital Memories (1985)

Article Möglichkeiten der drahtlosen Biosignalerfassung mittels digitaler Speicherung - Possibilities of Wireless Recording of Biosignals by Means of Digital Memories was published on January 1, 1985 in the journal Biomedical Engineering / Biomedizinische Technik (volume 30, issue 4).
Adaptation of subchondral bone in osteoarthritis. (2004)

Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has never been proven. Recent studies showing reduced chemical and mechanical properties of subchondral bone in various stages of the disease have invigorated interest in the role of subchondral bone in the development and progression of the disease. The current study showed that the concept of bone adaptation might explain subchondral stiffening, a process where subchondral bone becomes typically sclerotic in osteoarthritis. In addition, we report reduced mechanical matrix tissue properties as well as an increase in denatured collagen content. In conclusion, although osteoarthritic bone tissue contains increased denatured collagen and has reduced matrix mechanical properties, the widely accepted concept of subchondral stiffening is compatible with the process of normal bone adaptation.
Molecular Architecture of a Sodium Channel S6 Helix (2013)

Structural modeling guided electrophysiology reveals the functional importance of radial tuning of the S6 segment. Voltage-gated sodium (NaV) channels are membrane proteins that consist of 24 transmembrane segments organized into four homologous domains and are essential for action potential generation and propagation. Although the S6 helices of NaV channels line the ion-conducting pore and participate in channel activation, their functional architecture is incompletely understood. Our recent studies show that a naturally occurring in-frame deletion mutation (Del-L955) of NaV1.7 channel, identified in individuals with a severe inherited pain syndrome (inherited erythromelalgia) causes a substantial hyperpolarizing shift of channel activation. Here we took advantage of this deletion mutation to understand the role of the S6 helix in the channel activation. Based on the recently published structure of a bacterial NaV channel (NaVAb), we modeled the WT and Del-L955 channel. Our structural model showed that Del-L955 twists the DII/S6 helix, shifting location and radial orientation of the activation gate residue (Phe(960)). Hypothesizing that these structural changes produce the shift of channel activation of Del-L955 channels, we restored a phenylalanine in wild-type orientation by mutating Ser(961) (Del-L955/S961F), correcting activation by ∼10 mV. Correction of the displaced Phe(960) (F960S) together with introduction of the rescuing activation gate residue (S961F) produced an additional ∼6-mV restoration of activation of the mutant channel. A simple point mutation in the absence of a twist (L955A) did not produce a radial shift and did not hyperpolarize activation. Our results demonstrate the functional importance of radial tuning of the sodium channel S6 helix for the channel activation.
Site and mechanism of action of dynorphin A-(1–13) andN-methyl-d-aspartate on ACTH release in fetal sheep (2002)

Dynorphin A (Dyn A) stimulates the release of ACTH in fetal sheep, a response that involves N-methyl-D-aspartate (NMDA) receptors but not the secretogogues corticotropin-releasing hormone or arginine vasopressin. We now find that neither Dyn A-(1-13) (0.5 mg/kg, i.v.) nor NMDA (4 mg/kg, i.v.) elicits ACTH release in postnatal lambs. This led us to hypothesize that Dyn A-(1-13) and NMDA might act to release placental ACTH. However, the ability of Dyn A-(1-13), NMDA, and the kappa-opioid receptor agonist U-50488H (1 mg/kg, i.v.) to release ACTH was lost after either fetal hypophysectomy (n = 4) or hypothalamo-pituitary disconnection (n = 4). These results indicate that neither the placenta nor the fetal pituitary is the site of action for these agonists and suggest a hypothalamic or suprahypothalamic site of action. Furthermore, the release of ACTH by Dyn A-(1-13) and NMDA was abolished after pretreatment with indomethacin, suggesting that they might cause the release of a prostanoid, possibly from the placenta, that subsequently acts at the hypothalamus or serves as a permissive factor in the action of Dyn A-(1-13) and NMDA at the hypothalamus.
Study on Development of High Mn Austenitic Heat Resisting Steel (1969)

High Mn austenitic stainless steel has been developed for high temperature applications especially for boiler tubes. The most suitable chemical composition has been found to be 18%Cr-6%Ni-8%Mn, the structure this steel is almost wholly austenitic and its properties of creep-rupture strength, resistance to oxidation at elevated temperature and hot workability are comparable to those of type 304 steel.Small amounts of Ti and Nb have been added simultaneously to this type of steel (being called 18-6-8Ti Nb steel) to improve the elevated temperature strength. The carbon content being about 0.2%, the optimum amounts of Ti and Nb have been found to be the atomic ratio of (Ti+Nb)/C being in the range of 0.1 to 0.5. The resultant steel has considerably high creep-rupture strength in the temperature 600 to 700°C, and is believed to be very economical steel for high temperature applications.The mechanism of raising the creep-rupture strength due to the additions of Ti and Nb is considered to be to depress the coalescence of M23C6 carbides in the grains and on the grain boundaries and to make the carbides dispersing very finely within the grains during its use at high temperature. This mechanism is seemed to be the same as in the case of 18%Cr-10%Ni austenitic steel.
Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma (2012)

3-Nitrotyrosine (3NT) is known as an important indicator of nitrosative stress and has been linked to various diseases. Our aim was to develop an indirect ELISA (enzyme-linked immunosorbent assay) method suitable for the detection of protein-bound 3NT in clinical plasma and serum samples. Nitrated protein standards and reduced protein standards were prepared. Limit of detection was determined for standards; recovery and reproducibility were determined for human plasma samples. The limit of detection for this method is 1.82±0.56 pmol/mg protein. Mean recovery of standards was 95%. 3NT concentration in plasma samples of obese and normal weight subjects was determined to be between 2 pmol/mg and 19 pmol/mg. No time-consuming sample preparation or expensive laboratory equipment is required, and applied antibodies are commercially available. Sensitivity, rapid analysis time, possibilities of high throughput applications and small sample volumes make this ELISA attractive for use in clinical laboratories.
Determination of Carbohydrate Content in Bananas during Ripening and Storage by near Infrared Spectroscopy (2000)

Near infrared (NIR) spectroscopy was used to establish calibration equations to determine individual sugar content in Cavendish bananas that corresponds to the stage of ripeness. Using high performance liquid chromatography as the reference method, a NIRSystems monochromator and ISI software for scanning and data analysis, calibration models for prediction of individual sugar content were developed. A modified partial least squares (MPLS) algorithm was used to perform the calibration. A wavelength range of 1100–2500nm was selected for evaluation. The standard error of performance ( SEP) and coefficient of determination ( R 2 ) for individual sugars were as follows: sucrose 0.78% and 0.97, respectively; glucose 0.21% and 0.96, respectively; fructose 0.16% and 0.95, respectively. SEP and R 2 for total sugar content were 0.80% and 0.98, respectively.
Enzyme Activity Using a Perfluoropolyether-Modified NAD(H) in Fluorous Solvents and Carbon Dioxide (2002)

The purpose of this research was to investigate the viability of developing biocatalysis in "green" solvents such as fluorous solvents and CO2 using a soluble cofactor. The cofactor nicatinamide adenine dinucleotide (NAD) was covalently modified with a perfluoropolyether. Solubility studies of the modified NAD (FNAD) were performed in CO2 by generating cloud point curves. At weight percents 1.2% to 2%, FNAD demonstrated solubility in liquid CO2 at pressure above 1300 psi. The activity of horse liver alcohol dehydrogenase (HLADH) using FNAD as the coenzyme was investigated in the fluorous solvent methoxy-nonafluorobutane (HFE). The activity increased with an increase in the amount of FNAD added. The activity using FNAD was compared with the activity using the same molar amount of unmodified NAD. The activity using FNAD was greater than that of NAD. Preliminary activity studies in CO2 demonstrated that FNAD was functional; however, future kinetic studies are necessary.
20. Emili Mira i López. El test de Mira (2011)

Test de Mira. Prova, d’expressio grafica, que es proposa detectar el que es pot anomenar la formula actitudinal de l’individu que s’examina amb aquesta prova; es a dir, les seves tendencies fonamentals de reaccio, constituents de les seves peculiaritats de temperament i caracter. Es coneix tambe com Psicodiagnostic miokinetic, PMK, Test miokinetic d’E. Mira i Lopez i Prova grafo-expressiva d’Emili Mira i Lopez.
Segmentation of the left ventricle in 4D-dSPECT data using free-form deformation of super quadrics (2004)

In dynamic SPECT (dSPECT) images, function of a particular organ may be analyzed by measuring the temporal change of the spatial distribution of radioactive tracer. The organ-specific and location-specific time-activity curves (TAC) of the different heart regions (regions with normal blood circulation and with disturbed blood circulation) are helpful for the diagnosis of heart diseases.A problem of the derivation of the TACs is that the dSPECT images have a poor spatial and temporal resolution and the data is distorted because noise effects, partial volume effects and scatter artifacts. Therefore in a preprocessing step the quality of the data is improved with a nonlinear isotropic diffusion in combination with the principal component analysis. Segmentation according to some homogeneity principle will deliver regions of similar functional behavior but the segmented regions do not directly point to anatomy. For our goal of anatomy specific segmentation information about anatomy is provided a-priori and it must be fitted to the data. For initialization the user have to mark six positions of the left ventricle in the data set which are used to place a super ellipsoid. The parameters of this super ellipsoid are obtained from the computed mean shape of six manual segmented left ventricles in test data sets. A closer fit to the high gradients of the boundaries of the heart wall is achieved using the free form deformation method. For evaluation segmentation results are compared with a manual segmentation. In all test images we could ascertain a good correspondence between the manual and automatic segmentation.
Consejos para mantener una espalda sana (2005)

The Heart Hospital of Austin, Texas opened in 1998 after more than 2 years of planning and political struggles. A committed group of cardiologists had a vision of a physician-driven and patient-focused model of cardiovascular care. To ensure the success of the project the physician group grew and placed full-time cardiologists in surrounding communities. The physician group also concentrated on new programs to improve the cardiovascular health of Central Texans. Volume, efficiency, and quality indices point to the Heart Hospital of Austin as a leader in cardiovascular care.
Metric Temporal Description Logics with Interval-Rigid Names (2020)

In contrast to qualitative linear temporal logics, which can be used to state that some property will eventually be satisfied, metric temporal logics allow us to formulate constraints on how long it may take until the property is satisfied. While most of the work on combining description logics (DLs) with temporal logics has concentrated on qualitative temporal logics, there is a growing interest in extending this work to the quantitative case. In this article, we complement existing results on the combination of DLs with metric temporal logics by introducing interval-rigid concept and role names. Elements included in an interval-rigid concept or role name are required to stay in it for some specified amount of time. We investigate several combinations of (metric) temporal logics with A ℒ C by either allowing temporal operators only on the level of axioms or also applying them to concepts. In contrast to most existing work on the topic, we consider a timeline based on the integers and also allow assertional axioms. We show that the worst-case complexity does not increase beyond the previously known bound of 2-E xp S pace and investigate in detail how this complexity can be reduced by restricting the temporal logic and the occurrences of interval-rigid names.
Development of pH sensitive films for monitoring spoilage volatiles released into packaged fish headspace (2003)

Amines such as trimethylamine (TMA), dimethylamine (DMA) and NH 3 , collectively known as total volatile basic nitrogen (TVB-N), are released from fish during spoilage. Cresol red was successfully entrapped within a plasticised cellulose acetate matrix to produce sensors that could monitor the levels of TVB-N released from fish. The dye does not differentiate between the different bases that are released during spoilage but instead responds to any base capable of deprotonating it. Calibration of the sensors using a red light source and a monochrome digital camera suggested that a simple illumination source [such as a light emitting diode (LED)] and a detector (such as a photodiode) could be used to monitor colour changes in the sensors. The pK a of the dye in the solid-phase dye coatings did not vary significantly from that in free solution. There was a linear relationship between the colour intensity of the dye at 573 nm and the log of the NH 3 concentration in the headspace. Whiting, obtained from a local market and stored at room temperature, showed a definite and measurable increase in TVB-N levels between 24 and 30 h. Orange roughy and black scabbard, deepwater fish obtained under known conditions, showed a rise in TVB-N levels between 30 and 45 h when stored at room temperature. Samples stored on ice took 160 to 200 h to achieve similar levels of spoilage.
Modeling and Frequency Performance Analysis of Through Silicon Capacitors in Silicon Interposers (2017)

The feasibility of cointegration of new capacitors, named “through silicon capacitors” (TSCs) with “through silicon vias” in silicon interposers has recently been demonstrated. Two architectures of TSC are extensively investigated in this paper: “axial TSC” whose electrodes are connected on either sides of the silicon interposer and “radial TSC” with electrodes both connected to the metal layers of the back end of line. A general modeling method based on distributed cell segmentation is proposed for both architectures. Validation is performed by measurements from 1 kHz to 40 GHz (above the resonance frequency of the components). A comparative study between radial and axial architectures is performed, leading to the prediction of the performances of those new components. Finally, design rules are established for future integration for power delivery networks decoupling applications.
Combined grazing-angle and normal-incidence reflectometry of absorbing media (1999)

We have studied the grazing-incidence differential-reflectance method for obtaining the dielectric function of absorbing media in terms of the derivatives Rp′ and Rs′ of the polarized light reflectances and found that it does not guarantee adequate accuracy for almost any values of the optical parameters. Therefore we modify that approach and describe what we believe is a novel method for the unambiguous determination of the optical constants n and k of a metal and other absorbing materials in terms of the ratio of the derivatives α=Rp′/Rs′ at the grazing incidence and the normal incidence reflection coefficient R. Moreover, it is possible to express α through the logarithmic derivatives (1/R)R′ in the vicinity of the grazing angle. The possibility of performing measurements at the unspecified angle without knowledge of the explicit value of this angle is an evident advantage of this technique. For the great majority of metals and semiconductors the relative errors in the optical constants are comparable to or less than the relative errors in the experimentally measured parameters.
A Simulation Study of the Planar Electrostatic Ion Trap Mass Analyzer (2013)

The Planar electrostatic ion trap expands the trapping space of the linear electrostatic ion trap, giving rise to higher tolerance to space charge. A rotational symmetrical design was made, which has a trapping field between two layers of concentric circular electrodes, and the ions are trapped to oscillate around the center plane between the electrodes. The oscillatory motions of the ions were simulated and the field distribution was optimized to achieve isochronous motion against energy spread in R, z, and φ directions. The image charge signal can be picked up by more than one circular electrode and using FFT the mass resolution for the optimized trap can reach 80,000 FWHM. While Fourier transform of the image charge signal generates many high harmonic peaks, the unwanted harmonic peaks can be eliminated by linear combination of image charge signals from multiple pick-up electrodes to give satisfactory results.
Self‐template hydrothermal synthesis ZnS microspheres (2011)

Abstract Zinc sulfide (ZnS) microspheres were synthesized by a self‐template hydrothermal route using thiourea as sulphur source. The formation of these hollow spheres was mainly attributed to the oriented aggregation of ZnS nanocystals around the gas‐liquid interface between gas (H 2 S, NH 3 , or CO 2 ) and water followed by an Ostwald ripening process. The gas bubbles of H 2 S, NH 3 , or CO 2 produced during the reaction might play a soft‐template to form ZnS hollow microspheres. The products were characterized by X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), electron diffraction (ED), and photoluminescence (PL). The crystal structure of prepared ZnS microspheres is hexagonal phase polycrystalline. The average microspheres diameter is 1.5 ‐ 6 µm. (© 2011 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer (2015)

Agents that inhibit SPHK1 or S1P could overcome cytotoxic drug resistance in gastroesophageal cancer. There are several agents in early phase human trials including Safingol that could be combined with chemotherapy or used in patients progressing after chemotherapy.
Abstract 237: Intronic 27-nt Mirna Suppresses The Expression Of Endothelial Nitric Oxide Synthase Predominantly Through Nuclear Transcription Factor Ap-1 (2014)

The 27-base pair (bp) repeats in intron 4 were considered as the source of small RNA that suppressed endothelial nitric oxide synthase (eNOS) expression in endothelial cells. The present study was to investigate the role of polymorphic intronic 27-nucleotide (nt) miRNA and nuclear transcription factors (TFs) in eNOS expression in endothelial cells. The 27-nt or 54-nt miRNA or their mutants (with 3 mutations at 13, 14, and 15 th nt for 27-nt mutant and at 13,14,15,40,41,42 th nt for 54-nt mutant) were stably transfected and expressed in human aortic endothelial cells (HAECs). Overexpression of 27-nt miRNA and its duplexes and mutants significantly decreased eNOS mRNA level and protein content. Interestingly, more reduction in eNOS protein was observed in the cells overexpressing the mutant miRNAs than the cells overexpressing the wild-type ones for both 27-nt and 54-nt miRNAs. Western blotting showed that transcription factor Ap-1 expression was substantially decreased in the cells that overexpressed either 27-nt or 54-nt miRNAs (both wild-type and mutants). Augmented inhibition of Ap-1 expression was observed in the cells overexpressing the mutant 27-nt miRNA as compared with the wild-type. However, Sp-1 protein expression was significantly suppressed only in the cells overexpressing 54-nt miRNA. Silencing Ap-1 abolished the polymorphic effect of miRNAs both in length and mutation on eNOS expression; while Sp-1 silencing only reversed the polymorphic effect of mutant miRNAs. These results suggested that overexpression of intron 4-based 27-nt miRNAs suppressed eNOS gene expression polymorphically through interactions predominantly with nuclear transcription factors Ap-1 in HAECs.
Sharing Profits (2014)

Any decision by a company regarding the use of profits to pay tax, remuneration or shareholder returns has ethical implications. Sharing Profits reviews high-profile ethical issues facing companies in
Optimization of submerged culture conditions for the production of angiotensin converting enzyme inhibitor from Flammulina velutipes (2002)

The angiotensin-converting enzyme (ACE) inhibitory effect was tested in the culture broth from submerged mycelial cultures of 20 basidiomycetes. The ACE inhibitory effect of culture broth from Flammulina velutipes strain 414 was the highest (52.8%), followed by Lentinus edodes strains 2 (44.4%) and 16 (41.3%). Nutritional requirements for the production of ACE inhibitory substance from F. velutipes were studied. Sucrose, ammonium acetate, and glutamic acid were chosen for the maximum production of ACE inhibitory substance. The optimal medium composition was (g/l): sucrose 20, ammonium acetate 5, glutamic acid 2, KH2PO4 3, MgSO4·7H2O 0.8, and yeast extract 0.5. Under optimal culture conditions, the ACE inhibitory effect was more than 80%.
Active Microvibration Control of Precision Manufacturing Facilities with Smart Structure Using Piezoelectric Actuator. (2000)

A smart structure was tested for active microvibration control of a 2-story steel frame building model of a 5×3×4Hm outer size and a 2 500 kg total weight which was excited by ambient ground vibration. In the structure, piezoelectric actuators attached to the columns and the beams were used for the microvibration control by bending moment control of them. The controller was designed using the H ∞ control theory. The tests showed that the smart structure could effectively reduce the three-dimensional microvibration of the building model, and its applicability to floors and even entire buildings of semiconductor manufacturing factories having steel frame structures.