gebhart/patrepeval huggingface dataset:
High-resolution adaptive imaging with a single photodiode (2015)

During the past few years, the emergence of spatial light modulators operating at the tens of kHz has enabled new imaging modalities based on single-pixel photodetectors. The nature of single-pixel imaging enforces a reciprocal relationship between frame rate and image size. Compressive imaging methods allow images to be reconstructed from a number of projections that is only a fraction of the number of pixels. In microscopy, single-pixel imaging is capable of producing images with a moderate size of 128 × 128 pixels at frame rates under one Hz. Recently, there has been considerable interest in the development of advanced techniques for high-resolution real-time operation in applications such as biological microscopy. Here, we introduce an adaptive compressive technique based on wavelet trees within this framework. In our adaptive approach, the resolution of the projecting patterns remains deliberately small, which is crucial to avoid the demanding memory requirements of compressive sensing algorithms. At pattern projection rates of 22.7 kHz, our technique would enable to obtain 128 × 128 pixel images at frame rates around 3 Hz. In our experiments, we have demonstrated a cost-effective solution employing a commercial projection display.
Identifying rare, medically-relevant genetic variation in a diverse population: opportunities and pitfalls (2020)

ABSTRACT Purpose To evaluate the effectiveness and specificity of population-based genomic screening in Alabama. Methods The Alabama Genomic Health Initiative (AGHI) has enrolled and evaluated 5,369 participants for the presence of pathogenic/likely pathogenic (P/LP) variants using the Illumina Global Screening Array (GSA), with validation of all P/LP variants via Sanger sequencing in a CLIA-certified laboratory before return of results. Results Among 131 variants identified by the GSA that were evaluated by Sanger sequencing, 67 (51%) were false positives (FP). For 39 of the 67 FP variants, a benign/likely benign variant was present at or near the targeted P/LP variant. Importantly, African-Americans were significantly enriched for FP variants, likely due to a higher rate of non-targeted alternative alleles close to array-targeted P/LP variants. Conclusion In AGHI, we have implemented an array-based process to screen for highly penetrant genetic variants in actionable disease genes. We demonstrate the need for clinical validation of array-identified variants in direct-to-consumer or population testing, especially for diverse populations.
Enantioselective Phase‐Transfer Catalysis: Synthesis of Pyrazolines (2010)

All paired up: Under catalytic phase-transfer conditions the formation of a chiral ion pair between quininium cation 1 and hydrazine anion 2 led to an enantioselective aza-Michael cyclocondensation domino reaction to furnish pyrazolines. A convenient one-pot protocol allowed exchange of the functional group (R1) on the nitrogen atom. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of implant length variations on stress shielding in proximal humeral replacement after tumor excision under torsion: Finite element study (2022)

The proximal humerus is the most common site of occurrence of primary bone tumors in the upper limb. Endoprosthetic replacement is deemed as the preferred reconstructive option following primary resection of bone tumors. However, it has been also associated with complications such as stress shielding and aseptic loosening compromising prosthetic survival. Our objective was to conduct a finite element (FE) study to investigate the effect of varying endoprosthesis length on bone stresses as well as to quantify the extent of stress shielding across the bone length (BL) in a humerus-prosthesis assembly for proximal humeral replacement after tumor excision thereby allowing us to identify the optimal implant length with best biomechanical performance. FE models of the intact humerus and humerus-prosthesis assemblies were established where they were loaded at the elbow joint under torsion with the glenohumeral joint fixed to represent twisting. After dividing the bone into individual slices consisting of 5% BL, the maximum cortical and cancellous principal, von Mises and shear bone stresses were calculated. To measure the level of stress shielding, the percentage stress change from the intact state was evaluated across each slice. Similar stress patterns were observed between the intact state and shorter endoprosthesis compared to the longer endoprostheses. Our findings illustrated the possibility of stress shielding occurring under torsional forces with its effect increasing with implant lengthening. To conclude, we believe that using a shorter prosthesis may substantially diminish the risk of potential implant failure due to stress shielding.
A novel multiplex PCR assay forSalmonellasubspecies identification (2009)

The assay will be useful for characterizing Salmonella isolates from reptiles, which belong to various subspecies, and therefore add to the scientific understanding of reptile-associated Salmonellosis.
Enhancement in the interfacial perpendicular magnetic anisotropy and the voltage-controlled magnetic anisotropy by heavy metal doping at the Fe/MgO interface (2018)

We investigated the influence of heavy metal doping at the Fe/MgO interface on the interfacial perpendicular magnetic anisotropy (PMA) and the voltage-controlled magnetic anisotropy (VCMA) in magnetic tunnel junctions prepared by sputtering-based deposition. The interfacial PMA was increased by tungsten doping and a maximum intrinsic interfacial PMA energy, Ki,0 of 2.0 mJ/m2 was obtained. Ir doping led to a large increase in the VCMA coefficient by a factor of 4.7 compared with that for the standard Fe/MgO interface. The developed technique provides an effective approach to enhancing the interfacial PMA and VCMA properties in the development of voltage-controlled spintronic devices.
A Complete Statistical Investigation of RTN in HfO<sub>2</sub>-Based RRAM in High Resistive State (2015)

In this paper, we investigate the random telegraph noise (RTN) in hafnium-oxide resistive random access memories in high resistive state (HRS). The current fluctuations are analyzed by decomposing the multilevel RTN signal into two-level RTN traces using a factorial hidden Markov model approach, which allows extracting the properties of the traps originating the RTN. The current fluctuations, statistically analyzed on devices with a different stack reset at different voltages, are attributed to the activation and deactivation of defects in the oxidized tip of the conductive filament, assisting the trap-assisted tunneling transport in HRS. The physical mechanisms responsible for the defect activation are discussed. We find that RTN current fluctuations can be due to either the coulomb interaction between oxygen vacancies (normally assisting the charge transport) and the electron charge trapped at interstitial oxygen defects, or the metastable defect configuration of oxygen vacancies assisting the electron transport in HRS. A consistent microscopic description of the phenomenon is proposed, linking the material properties to the device performance.
Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP (2023)

Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
Evacuated Airship for Mars Missions: NIAC Phase I, 2017 (2018)

An evacuated or vacuum airship relies on the same principle of buoyancy used by standard balloons. However, unlike a balloon which uses a lighter than air gas to displace air and provide lift, the vacuum airship leverages a rigid structure to maintain a vacuum and displace air, thereby providing buoyancy. This method is similar to how a ship uses a rigid structure to displace water and fill the space with air; an evacuated airship uses the same mechanism, except air is displaced and the space remains vacant. Using this method, the evacuated airship is capable of utilizing the full potential of the displaced mass of air, which has interesting implications in the Martian atmosphere. Unlike other aerial vehicles, which are at a disadvantage in Martian atmospheric conditions, the evacuated airship benefits from the Martian atmosphere by virtue of the temperature and molecular composition. As a result, the evacuated airship offers an unprecedented payload capacity and, if implemented, may be used to transport current and future scientific instruments, other vehicles, rovers, and possibly even human habitations. A standard dirigible or balloon for Mars would have a severely limited span of operation and a very narrow field of study, nearly exclusively the atmosphere, but a vacuum airship can be used as a long term tool for many different missions: transportation, ground study, communications, atmospheric study, etcetera, thereby making it a far more economically sensible choice
Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS (2012)

Taurine supplementation may be a novel potential treatment option for preventing the stroke-like episodes associated with MELAS.
Tech Insider | Tevva Truck (2021)

Following seven years of engineering development and hundreds of thousands of miles travelled in real-world trials, UK-based manufacturer Tevva is ready to deliver electrification to the medium and heavy-duty commercial vehicle market in the form of a 7.5-ton truck with dual powertrain options
EFFECT OF GRAVIDITY ON MATERNAL SERUM MARKERS FOR DOWN'S SYNDROME (1996)

The effect of gravidity on maternal serum alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotrophin (hCG) levels was investigated in 27,592 women being screened for Down's syndrome. There was no difference in the median AFP level in primigravid and multigravid women, but the median hCG level in multigravid women was 5.9 per cent lower than in those tested in their first pregnancy (P < 0.0001) and the median uE3 level was 3.9 per cent lower (P < 0.0001). Among multigravid women, there was no material difference in hCG levels according to the number of previous pregnancies or livebirths, whereas uE3 levels declined steadily with increasing numbers. Both markers declined with advancing maternal age: for hCG this was an independent effect, but for uE3 it was due to the correlation between age and gravidity. Allowing for these effects will not greatly alter the Down's syndrome screening detection and false-positive rates.
Enantioselective, Cyclopentene-Forming Annulations via NHC-Catalyzed Benzoin−Oxy-Cope Reactions (2007)

Chiral N-heterocyclic carbene catalysts generated from triazolium salts promote the cyclopentene-forming annulation of α,β-unsaturated aldehydes and 4-oxoenoates with excellent levels of enantioinduction and preference for the cis-1,3,4-trisubstituted cyclopentene diastereomer. Although the observed products could arise by conjugate additions of catalytically generated homoenolates, our mechanistic and stereochemical investigations strongly support a novel reaction manifold featuring an intermolecular crossed-benzoin reaction and an NHC-catalyzed oxy-Cope rearrangement.
Real-Time Lookahead Imaging Using the Drill Bit as Seismic Source (2021)

Abstract We monitor the seismic signal emitted from a rotating drill bit in real time with an array of seismic sensors at the seafloor. Drill-bit seismic signals provide information to locate the drill-bit position itself and to image geological objects ahead and around the drill bit for geosteering purposes during drilling operations. The data can be obtained in real time without the need to stop drilling for logging and without any additional downhole instrumentation in the bottom hole assembly. Drill-bit positioning accuracy is independent of measured depth and with meter level lateral precision. This is significantly better than conventional downhole gyro-based methods, especially for long horizontal wells. With sources along the drilled well path approaching a target reservoir we obtain a 3D reverse VSP (RVSP) image around the well for prediction ahead of the drill bit. This paper presents a case study from the Grane reservoir in the North Sea, where we utilize a permanent reservoir monitoring (PRM) array for listening to signals emitted from drilling with a PDC bit. We present imaging results from a highly deviated well and compare them to 3D seismic. The field example shows the ability to look ahead several hundreds of meters below the drilled well trajectory.
Ferritin as a reporter gene for MRI: chronic liver over expression of h‐ferritin during dietary iron supplementation and aging (2010)

The iron storage protein, ferritin, provides an important endogenous MRI contrast that can be used to determine the level of tissue iron. In recent years the impact of modulating ferritin expression on MRI contrast and relaxation rates was evaluated by several groups, using genetically modified cells, viral gene transfer and transgenic animals. This paper reports the follow-up of transgenic mice that chronically over-expressed the heavy chain of ferritin (h-ferritin) in liver hepatocytes (liver-hfer mice) over a period of 2 years, with the aim of investigating the long-term effects of elevated level of h-ferritin on MR signal and on the well-being of the mice. Analysis revealed that aging liver-hfer mice, exposed to chronic elevated expression of h-ferritin, have increased R(2) values compared to WT. As expected for ferritin, R(2) difference was strongly enhanced at high magnetic field. Histological analysis of these mice did not reveal liver changes with prolonged over expression of ferritin, and no differences could be detected in other organs. Furthermore, dietary iron supplementation significantly affected MRI contrast, without affecting animal wellbeing, for both wildtype and ferritin over expressing transgenic mice. These results suggest the safety of ferritin over-expression, and support the use of h-ferritin as a reporter gene for MRI.
Direction-finding performance of the multistage CM array (2002)

The constant modulus (CM) array is a blind adaptive beamformer that steers nulls in the directions of cochannel interferers without requiring a training (pilot) signal. A cascade implementation of the system, known as the multistage CM array, is designed to recover ("copy") several narrowband cochannel signals and provide estimates of their angles of arrival. Each stage is composed of a CM array that "captures" one of the sources and an adaptive signal canceler that removes the source from the array input. This signal cancelation influences the capture and direction finding performance of the remaining stages. The authors quantify this behavior using a stochastic model of convergence and present computer simulation results for some example source scenarios.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modes of rearrangement in substituted octahedral complexes (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModes of rearrangement in substituted octahedral complexesJeremy I. Musher and William C. AgostaCite this: J. Am. Chem. Soc. 1974, 96, 5, 1320–1325Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/ja00812a010https://doi.org/10.1021/ja00812a010research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of organically modified silica nanoparticles for monitoring the intracellular level of oxygen using a frequency-domain FLIM platform (2015)

The dynamic quenching of luminescence derived from Ru(dpp<sub>3</sub>)<sup>2+</sup>-doped ORMOSIL nanoparticles is used for monitoring of the intracellular oxygen concentration.
Introduction (1996)

The gendered nature of the public and private spheres, economy and polity versus home and family, has long operated as given in traditional sociology. The sociological task has been to document the emergence of these spheres, to understand their interrelations, and to reveal the ideological dimension of their operation. In the course of this task, the artificial nature of the division itself has become apparent, manifest for example in arguments about the productive nature of domestic work, the gendered assumptions and controls embedded in aspects of social policy, gender segregation in the labour market, etc. There is still, however, a need for research which records the way in which aspects of the public sphere can be shaped around assumptions carried over from the private, and the way in which the private sphere is shaped by influences generated in the public. Thus, in the spirit of C. Wright Mills (1973) and his concern to link private troubles to public issues, we offer here some documentation of the inter-connections of the public and private spheres.KeywordsLabour MarketDomestic ViolencePublic SpherePrivate SpherePublic IssueThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The Proteasome Inhibitor BSc2118 Causes Growth Inhibition, Cell Cycle Arrest and Cyclin D1 Degradation in Mantle Cell Lymphoma Cell Lines. (2007)

Abstract The ubiquitin-proteasome complex has recently been identified as a novel therapeutic target, particularly in hematological malignancies. An increased proteasome activity has been described in certain types of malignant cells including mantle cell lymphoma (MCL). The proteasome inhibitor bortezomib has shown in vitro activity in MCL cell lines and also clinical efficacy in patients with refractory or relapsed MCL. We previously described a novel tripeptide compound, BSc2118 which inhibits all three proteolytic activities of the 20S proteasome and has anti-tumor activity in melanoma and multiple myeloma (Cancer Res2006; 66: 7598–7605). We investigated the anti-tumor effects of BSc2118 in the MCL cell lines HBL-2, JeKo-1 and Granta-519 and studied its effects on cell cycle progression and the expression of the cell cycle regulatory proteins p21, p27 and cyclin D1. Furthermore the inhibition of intracellular proteasome and NF-kappa B activity was analyzed in MCL cells. In MCL cell lines HBL-2, JeKo-1 and Granta-519, BSc2118 caused a time- and dose-dependent growth inhibition, an induction of apoptosis and a dose-dependent inhibition of intracellular proteasome activity. After 24 and 48 hours of incubation with 40 – 260 nM BSc2118 we found a time- and dose-dependent cell cycle arrest in G2/M phase in all three MCL cell lines. Furthermore we could demonstrate a dose-dependent stabilization of p21 and a degradation of cyclin D1 in western blot analysis. No significant changes could be seen in p27 expression under proteasome inhibition with BSc2118. After TNF-alpha stimulation we found a low NF-kappa B activity also in untreated MCL cells, which could be partially inhibited by preincubation with BSc2118. In this study we show the effects of the novel proteasome inhibitor BSc2118 on cell cycle and growth inhibition in MCL cells lines and furthermore demonstrate that inhibition of proteasome activity, cyclin D1 degradation and p21 stabilization are crucial mechanisms of action for this compound in MCL. Since recent trials have shown a clinical efficacy of proteasome inhibition in MCL, our preclinical data suggest to consider BSc2118 as a novel agent in drug development against MCL.
Microvascular Perturbations in Human Allografts: Analogies in Preeclamptic Placentae (1992)

The thromboresistance of endothelium is maintained as long as natural anticoagulant pathways are functionally present on endothelial plasma membranes. The principal anticoagulant pathways in human hearts and kidneys are thrombomodulin (TM) and heparan sulfate proteoglycan-antithrombin III (HSPG-ATIII). The downregulation of TM or the loss of ATIII is associated with fibrin deposition. This sequence of events occurs when stable allografts of hearts or kidneys become unstable or rejected. Human placentae do not contain the HSPG-ATIII natural anticoagulant pathway, but the TM system is uniformly represented on endothelium of normal chorionic villi. However, many villi in placentae from preeclamptic pregnancies contain thrombomodulin-negative endothelium, and these vessels contain fibrin thrombi. These thrombi compromise blood flow through the placental microcirculation and are associated with ischemic changes either with or without the presence of cellular infiltrates.
Multimodal improvements after apomorphine treatment for chronic disorders of consciousness: preliminary results (2019)

peer reviewed
CrystPro: Spatiotemporal Analysis of Protein Crystallization Images (2015)

Thousands of experiments corresponding to different combinations of conditions are set up to determine the relevant conditions for successful protein crystallization. In recent years, high throughput robotic set-ups have been developed to automate the protein crystallization experiments, and imaging techniques are used to monitor the crystallization progress. Images are collected multiple times during the course of an experiment. Huge number of collected images make manual review of images tedious and discouraging. In this paper, utilizing <i>trace fluorescence labeling</i>, we describe an automated system called CrystPro for monitoring the protein crystal growth in crystallization trial images by analyzing the time sequence images. Given the sets of image sequences, the objective is to develop an efficient and reliable system to detect crystal growth changes such as new crystal formation and increase of crystal size. CrystPro consists of three major steps- identification of crystallization trials proper for spatio-temporal analysis, spatio-temporal analysis of identified trials, and crystal growth analysis. We evaluated the performance of our system on 3 crystallization image datasets (PCP-ILopt-11, PCP-ILopt-12, and PCP-ILopt-13) and compared our results with expert scores. Our results indicate a) 98.3% accuracy and .896 sensitivity on identification of trials for spatio-temporal analysis, b) 77.4% accuracy and .986 sensitivity of identifying crystal pairs with new crystal formation, and c) 85.8% accuracy and 0.667 sensitivity on crystal size increase detection. The results show that our method is reliable and efficient for tracking growth of crystals and determining useful image sequences for further review by the crystallographers.