gebhart/patrepeval huggingface dataset:
MR-Elastographie der Glandula parotidea: Erste Erfahrungen bei 3 Tesla (2012)

Ziele: Die dynamische Magnetresonanz-Elastographie (MRE) ermöglicht die dreidimensionale Rekonstruktion der viskoelastischen Parameter eines Gewebes. Ziel der vorliegenden Arbeit war die Entwicklung eines Versuchsaufbaus zur MRE der Ohrspeicheldrüse bei 3 Tesla. Methode: 27 gesunde Probanden (Nichtraucher, 17 Frauen, 10 Männer, Durchschnittsalter: 32 Jahre) wurden in Rückenlage mittels eines 3 Tesla Ganzkörperscanners (3T Intera; Philips Medical Systems, Best, The Netherlands) mit einer 6 Kanal SENSE-Kopfspule untersucht. Der Oszillator wurde bei allen Probanden an der linken Glandula parotidea platziert. Die angewandte Frequenz betrug 100Hz. Für die Datenakquisition wurde eine bewegungssensitive, echoplanare, transversale Spin-Echo-Sequenz (TR 301ms, TE 40ms, flip angle 90°, EPI Faktor 3, FOV 64mm, Schichtdicke: 2mm) verwendet. Es wurden fünf Schichten akquiriert. Die Akquisitionsdauer betrug 9,27min. Zusätzlich wurden 5 Probanden vor und nach oraler Stimulation mittels Zitronensaft untersucht. Die Elastizität wurde mittels des Maxwell-Modells berechnet. Zur Berechnung der Viskosität wurde das Voigt-Modell verwendet. Ergebnis: Mittels des entwickelten Versuchsaufbaus konnte bei 25 von 27 Probanden eine suffiziente Penetration der eingekoppelten Welle nachgewiesen werden. Die Amplitude der erzeugten Welle nahe dem Oszillator betrug 80 bis 100µm. Die mittlere Elastizität der untersuchten, nicht stimulierten Drüsen betrug 1,37±0,35 kPa, während die Viskosität mit 0,45±0,14Pa*s berechnet wurde. Nach oraler Stimulation wurde ein Anstieg beider Parameter nachgewiesen (1,48 kPa, 0,56Pa*s). Schlussfolgerung: Die vorliegende Arbeit zeigt die technische Durchführbarkeit der MRE der Glandula parotidea bei 3 Tesla. Die homogenen Ergebnisse lassen die Schlussfolgerung zu, das Erkrankungen der Ohrspeicheldrüse, die zu einer Veränderungen der viskoelastischen Parameter führen, mittels der vorgestellten Technik von gesundem Gewebe zu differenzieren sein dürften.
Breast Lymphoma and Leukemia: Imaging Features and Radiologic-Pathologic Correlation (2013)

Poster: ECR 2013 / C-2301 / Breast Lymphoma and Leukemia: Imaging Features and Radiologic-Pathologic Correlation by: J. Magalhaes, A. Galaghar, C. Fernandes, H. Duarte, J. Abreu e Silva, C. Leal, A. T. Aguiar, A. Guimaraes dos Santos, M. V. P. G. Almeida; Porto/PT
Three-dimensional visualization and quantitative analysis of cervical cell nuclei with confocal laser scanning microscopy. (2005)

Three-dimensional visualization and quantification of cell nuclei provide valuable medical information that can lead to a more objective diagnosis.
Isn't There a Better Way? (2004)

Abstract One day in 1986, the author had a mini-vision that the portable personal scale, more commonly known as the bathroom scale, could be reinvented so that it would be no more than a quarter inch in thickness and weigh no more than one pound. Then, it would be truly portable and one could even carry it around in one's bag on one's travels, like just another accessory. As a result, this chapter discusses The Tale of the Scale, which is the story of how this plan was conducted. Before elaborating on this mini-vision, it first explains what the author was doing in Bangkok of all places in the 1986 rainy season.
Evaluation of SPf66 malaria vaccine efficacy in Brazil. (1998)

This paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 years, were included in the study. Of the initial cohort, 572 participants completed the vaccination schedule. Clinical and parasitologic evaluations were obtained by active and passive searches on a periodic basis. The overall protective efficacy against P. falciparum infections was -1.6% (-32.9% to 22.4%), and 14.1% (-17.0% to 36.9%) for the first episode. The overall protective efficacy for P. vivax infections was -19.7% (-44.8% to 1.03%), and -10.8% (-41.1% to 12.8%) for the first episode. No statistical evidence of an overall significant protective effect of SPf66 malaria vaccine against P. falciparum and P. vivax malaria was obtained in this trial.
Upconverting phosphors in a dual-parameter LRET-based hybridization assay (2009)

Upconverting phosphors (UCPs) are lanthanide-doped sub-micrometer-sized particles, which produce multiple narrow and well-separated anti-Stokes emission bands at visible wavelengths under infrared excitation (980 nm). The advantageous features of UCPs were utilized to construct a dual-parameter, homogeneous sandwich hybridization assay based on a UCP donor and lanthanide resonance energy transfer (LRET). UCPs with two emission bands (540 nm and 653 nm) were exploited together with two appropriate fluorophores as acceptors. The energy transfer excited emissions of the acceptors were measured at 600 nm and 740 nm without any significant interference from each other. The autofluorescence limitation associated with conventional fluorescence was totally avoided as the measurements were carried out at shorter wavelength relative to the excitation. In the sandwich hybridization assay two different single-stranded target-oligonucleotide sequences were detected simultaneously and quantitatively with a dynamic range from 0.03 to 0.4 pmol (corresponding 0.35-5.4 nM). The UCPs enable multiplexed homogeneous LRET-based assay requiring only a single excitation wavelength, which simplifies the detection and extends the applicability of upconversion in bioanalytical measurements.
A knapsack problem formulation for relay selection in secure cooperative wireless communication (2011)

Cooperative jamming (CJ) schemes support secure wireless communication in the presence of one or more eavesdroppers. Larger numbers of cooperative relays provide better secrecy rate, while increasing the communication and synchronization needs associated with cooperative beamforming. For low density networks (small number of relays) the secrecy rate changes rapidly with an increase in the number of relays, while for higher density networks increasing the number of relays has significantly smaller effect on the secrecy rate. This research considers a resource-aware approach: instead of using all available relays, choose the smallest set of active relays that meet a predetermined performance goal. The problem is formulated as a knapsack problem that may be solved through an exhaustive search. As this search method has exponential complexity, three heuristic algorithms are proposed, offering significant complexity reduction. The first one relies on the individual relay secrecy rate with a greedy algorithm. The second one is based on the beamforming weights norms, and the third one successively selects relay nodes that minimize the performance gap between the temporal secrecy rate and the given secrecy rate goal. Simulation results demonstrate that relatively high secrecy rate may be achieved with a small number of active relays. The first method performs better for low secrecy rate threshold levels, while the second does so at high threshold. The third method combines the advantages of the previous two and offers performance very close to the optimum at the expense of higher complexity than the first two.
Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability (2021)

Circulatory inflammatory proteins play a significant role in anti-<i>Candida</i> host immune defence. However, little is known about the genetic variation that contributes to the variability of inflammatory responses in response to <i>C. albicans</i>. To systematically characterize inflammatory responses in <i>Candida</i> infection, we profiled 91 circulatory inflammatory proteins in peripheral blood mononuclear cells (PBMCs) stimulated with <i>C. albicans</i> yeast isolated from 378 individuals of European origin from the 500 Functional Genomics (500FG) cohort of the Human Functional Genomics Project (HFGP) and Lifelines Deep cohort. To identify the genetic factors that determine variation in inflammatory protein responses, we correlated genome-wide single nucleotide polymorphism (SNP) genotypes with protein abundance (protein quantitative trait loci, pQTLs) produced by the <i>Candida</i>-stimulated PBMCs. Furthermore, we investigated whether differences in survival of candidaemia patients can be explained by modulating levels of inflammatory proteins. We identified five genome-wide significant pQTLs that modulate IL-8, MCP-2, MMP-1, and CCL3 in response to <i>C. albicans</i>. In addition, our genetic analysis suggested that <i>GADD45G</i> from rs10114707 locus that reached genome-wide significance could be a potential core gene that regulates a cytokine network upon <i>Candida</i> infection. Last but not least, we observed that a trans-pQTL marked from SNP rs7651677 at chromosome 3 that influences urokinase plasminogen activator (uPA) is strongly associated with patient survival (<i>P</i><sub>survival</sub> = 3.52 x 10<sup>-5</sup>, OR 3). Overall, our genetic analysis showed that genetic variation determines the abundance of circulatory proteins in response to <i>Candida</i> infection.
14-day toxicity study from The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA (2023)

&lt;p&gt;Supplementary report&lt;/p&gt;
Durable Perovskite UV Sensor Based on Engineered Size-Tunable Polydimethylsiloxane Microparticles Using a Facile Capillary Microfluidic Device from a High-Viscosity Precursor (2020)

In this work, size-tunable polydimethylsiloxane (PDMS) microparticles are fabricated from a high-viscosity oil phase using a facile coflowing capillary microfluidic device and optimized aqueous phase composition. The dispersity of the microparticle size is tuned by engineering of the viscosity of the continuous phase and flow rate ratio that leads us to achieve monodisperse microparticles. Regarding the high potential of the PDMS microparticles for optical applications, efficient environmentally durable perovskite-based UV sensors are fabricated employing the designed size-tunable microparticles. Surprisingly, the UV sensors comprising CH<sub>3</sub>NH<sub>3</sub>PbBr<sub>3</sub> perovskite quantum dots as UV-sensitive nanocrystals embedded in transparent PDMS microparticles are water resistant because of the high hydrophobicity of PDMS. Remarkably, the UV sensors show a photoluminescence quantum yield as high as 75% that can be employed effortlessly as reusable leak detectors in different fluidic working systems.
Overview of Results Obtained During the 6-Year French-German CHANCE Project (2005)

The present paper gives an overview of the CHANCE research project (partly supported by the French DPAC and DGA and the German BMWA) which was started more than 6 years ago between the German and French Aerospace Research Centres DLR and ONERA, the University of Stuttgart and the two National Helicopter Manufacturers, Eurocopter and Eurocopter Deutschland. The objective of the project was to develop and validate CFD tools for computing the aerodynamics of the complete helicopter, accounting for the blade elasticity by coupling with blade dynamics. The validation activity of the flow solvers was achieved through intermediate stages of increasing geometry and flow modelling complexity, starting from an isolated rotor in hover, and concluding with the time-accurate simulation of a complete helicopter configuration in forward-flight. All along the research program the updated versions of the CFD codes were systematically delivered to industry. This approach was chosen to speed up the transfer of capabilities to industry and check early enough that the products meet the expectations for applicability in the industrial environment of Eurocopter.
Cluster-based multi-channel communications protocols in vehicle ad hoc networks (2006)

The dedicated short range communications (DSRC) standard equipped with seven channels is designated for intelligent transportation system (ITS) applications to improve the driving safety and support networking services among moving vehicles. Making best use of the DSRC multichannel architecture, we propose a cluster-based multichannel communications scheme, which integrates the clustering with contention-free/contention-based MAC protocols. In our proposed scheme, the elected cluster-head (CH) vehicle functions as the coordinator (like WLAN's basestation) to collect/deliver the real-time safety messages within its own cluster and forward the consolidated safety messages to the neighboring CHs. Also, the CH vehicle controls channel-assignments for cluster-member vehicles transmitting/receiving the non-real-time traffics, which makes the wireless channels more efficiently utilized for the non-real-time data transmissions. Our scheme uses the contention-free MAC (TDMA/broadcast) within a cluster and the IEEE 802.11 MAC among CH vehicles such that the real-time delivery of safety messages can be guaranteed. The simulation results show that our proposed scheme can significantly improve the throughputs of vehicle data communications while guaranteeing the real-time delivery of safety messages
Compatible controller-motor system for battery-electric vehicle (1970)

The thyristor controller and the d.c. motor of a battery-electric vehicle are considered as a system. The advantage of combining a current-controlled chopper regulator, using digital techniques, with a laminated-field series motor is outlined, design criteria are suggested, and an experimental system is described. Performance measurements using specially developed wattmeters are presented, which show the division of losses in the system, and the exceptionally high overall efficiencies over the speed range.
Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain (2018)

Aging-related tau astrogliopathy (ARTAG) describes tau pathology in astrocytes in different locations and anatomical regions. In the present study we addressed the question of whether sequential distribution patterns can be recognized for ARTAG or astroglial tau pathologies in both primary FTLD-tauopathies and non-FTLD-tauopathy cases. By evaluating 687 postmortem brains with diverse disorders we identified ARTAG in 455. We evaluated frequencies and hierarchical clustering of anatomical involvement and used conditional probability and logistic regression to model the sequential distribution of ARTAG and astroglial tau pathologies across different brain regions. For subpial and white matter ARTAG we recognize three and two patterns, respectively, each with three stages initiated or ending in the amygdala. Subependymal ARTAG does not show a clear sequential pattern. For grey matter (GM) ARTAG we recognize four stages including a striatal pathway of spreading towards the cortex and/or amygdala, and the brainstem, and an amygdala pathway, which precedes the involvement of the striatum and/or cortex and proceeds towards the brainstem. GM ARTAG and astrocytic plaque pathology in corticobasal degeneration follows a predominantly frontal-parietal cortical to temporal-occipital cortical, to subcortical, to brainstem pathway (four stages). GM ARTAG and tufted astrocyte pathology in progressive supranuclear palsy shows a striatum to frontal-parietal cortical to temporal to occipital, to amygdala, and to brainstem sequence (four stages). In Pick's disease cases with astroglial tau pathology an overlapping pattern with PSP can be appreciated. We conclude that tau-astrogliopathy type-specific sequential patterns cannot be simplified as neuron-based staging systems. The proposed cytopathological and hierarchical stages provide a conceptual approach to identify the initial steps of the pathogenesis of tau pathologies in ARTAG and primary FTLD-tauopathies.
MARCO CONCEPTUAL DE UN DESARROLLO RURAL CIENTÍFICO TECNOLOGICO: PROPIO Y APROPIADO (2011)

En la. mayoría de los países en vía de desarrollo la agricultura y la economía especialmente la campesina, viven una crisis profunda que cada, vez hace más difícil y costosa la compra de insuinos procedentes del exterior. Esta crisis se ha intensificado a partir del modelo económico implantado en los años setenta. En la agricultura se pretendía realizar una revolución verde, que solucionaría los problemas crecientes de hambre y desnutrición en que viven millones de habitantes del llamado tercer mundo.
Low noise and low distortion GaAs mixer-oscillator IC for broadcasting satellite TV tuner (2003)

A monolithic low-noise and low-distortion mixer-oscillator IC has been developed for miniaturized coilless broadcasting satellite TV tuners. In order to obtain a high IP3 and low noise figure (NF), apportionment of gain and dynamic range in each circuit block were optimized. The fabricated IC, by using a newly developed asymmetric self-aligned LDD FET process, showed a conversion gain of 16.5 approximately 18.1 dB, a NF of 6.8 approximately 7.6 dB, and an IP3 of 23 approximately 25 dBm over the frequencies from 900 to 2000 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Naringin@Metal–Organic Framework as a Multifunctional Bioplatform (2022)

Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal-organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.
Measures of participation outcomes related to hand use for 2‐ to 12‐year‐old children with disabilities: a systematic review (2013)

Many interventions have been used to improve children's hand-related impairments or hand skill performance in functional activities so as to promote life participation. There is thus a need to have suitable instruments assessing children's participation in life situations that specifically require hand use in order to support and evaluate such interventions. This systematic review investigated the availability of potential instruments that can be used to assess children's participation specifically in life situations requiring hand use. Clinical utility and evidence for psychometric properties were also sourced. Database searches initially identified measures that were used to evaluate participation of children aged 2-12 years, involved self- or proxy report or interview administration and had generic application for a range of disabilities/diagnoses. These measures were further evaluated to determine if they fulfilled the above inclusion criteria and contained at least 60% of the items involving hand use. Further searches for psychometric evidence were undertaken for the eligible measures. Fourteen measures were identified and nine met the inclusion criteria. However, none of these measures, except for the Children Helping Out: Responsibilities, Expectations, and Supports (CHORES), contained all items related to hand use. Most of the included measures had limited psychometric properties. Only the Children's Assessment of Participation and Enjoyment/Preferences for Activities of Children (CAPE/PAC), the School Function Assessment-Participation section (SFA-P) and the Children Participation Questionnaire (CPQ) revealed sufficient evidence of validity and reliability. The findings suggest a need for adapting existing participation measures or developing new ones that specifically assess participation in life situations requiring hand use to support interventions.
Luminescent Dipyrrinato Complexes of Trivalent Group 13 Metal Ions (2006)

Although free dipyrrins (dipyrromethenes) do not strongly luminesce, certain dipyrrinato complexes of BF2 and zinc(II) are known to be intensely luminescent species. Two new dipyrrinato fluorophores, based on complexes with gallium(III) and indium(III), are described. Using a previously described meso-mesityl-substituted dipyrrin, namely 5-mesityldipyrrin (mesdpm), the complexes [Ga(mesdpm)3] and [In(mesdpm)3] were prepared and structurally characterized. The complexes display the expected octahedral geometry about the metal ions. In some solvents, such as hexanes, the complexes emit green light upon excitation with UV light at room temperature, with quantum yields of 2.4% ([Ga(mesdpm)3]) and 7.4% ([In(mesdpm)3]) and lifetimes in the low nanosecond range. Observations are consistent with assignment to ligand-localized transitions, and this interpretation is further confirmed by density functional calculations described herein. The new complexes are important additions to the widely used family of dipyrrin-based fluorescent species and show that dipyrrinato complexes containing metals other than BF2 and zinc(II) may be useful fluorophores.
Fine-Grained Energy Consumption Characterization and Modeling (2010)

Energy costs comprise a significant fraction of the total cost of ownership of a large supercomputer. As with performance, energy-efficiency is not an attribute of a compute resource alone; it is a function of a resource-workload combination. The operation mix and locality characteristics of the applications in the workload affect the energy consumption of the resource. Our experiments confirm that data locality is the primary source of variation in energy requirements. The major contributions of this work include a method for performing fine-grained power measurements on high performance computing (HPC) resources, a benchmark infrastructure that exercises specific portions of the node in order to characterize operation energy costs, and a method of combining application information with independent energy measurements in order to estimate the energy requirements for specific application-resource pairings. A verification study using the NAS parallel benchmarks and S3D shows that our model has an average prediction error of 7.4%.
Evaluation of a liquid bead array system for high-risk human papillomavirus detection and genotyping in comparison with Hybrid Capture II, DNA chip and sequencing methods (2010)

Since persistent infection with high-risk human papillomavirus (HPV) is a known cause of high-grade cervical intraepithelial neoplasia and cervical cancer, several HPV DNA detection methods have been developed during the last decade. The Hybrid Capture II (HCII) assay, which allows detection of 13 high-risk HPVs, has been well validated; however, it does not provide any genotype-specific information. The oncogenic activity of HPV is dependent on its genotype. The prophylactic effects of HPV vaccines are based on L1 virus-like particles and are limited mainly to infections corresponding to the HPV type used to develop the immunogen. Therefore, accurate detection and genotyping are important for treatment as well as screening. A newly developed HPV genotyping system using a liquid bead array was evaluated with 286 cervical samples and the results were compared to two commercially available methods, i.e. the HCII and HPV DNA chip assays, and sequencing. The sensitivity for detection of high-risk HPV was 85.3 % (HCII), 94.7 % (DNA chip) and 99.0 % (liquid bead array). The liquid bead array showed almost perfect agreement (κ=0.95) with genotype information confirmed by sequencing, while substantial agreement (κ=0.8) was observed between DNA chip and sequencing. Furthermore, the liquid bead array had superior detection of 26 HPVs (16 high-risk and 10 low-risk types) and has proven to be as accurate as sequencing in identifying individual HPV types, even in cases with multiple HPV infections.