gebhart/patrepeval huggingface dataset:
Peptide Signaling in the Staphylococci (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPeptide Signaling in the StaphylococciMatthew Thoendel, Jeffrey S. Kavanaugh, Caralyn E. Flack, and Alexander R. Horswill*View Author Information Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States* To whom correspondence should be addressed. Phone: 319 335 7783. Fax: 319 335 8228. E-mail: [email protected]. Address: 540F EMRB, University of Iowa, Iowa City, Iowa 52242.Cite this: Chem. Rev. 2011, 111, 1, 117–151Publication Date (Web):December 21, 2010Publication History Received29 October 2010Published online21 December 2010Published inissue 12 January 2011https://pubs.acs.org/doi/10.1021/cr100370nhttps://doi.org/10.1021/cr100370nreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views4521Altmetric-Citations318LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biofilms,Genetics,Infectious diseases,Monomers,Peptides and proteins Get e-Alerts
Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation (2020)

Mutations in CLRN1 cause Usher syndrome (USH) type III (USH3A), a disease characterized by progressive hearing impairment, retinitis pigmentosa, and vestibular dysfunction. Due to the lack of appropriate disease models, no efficient therapy for retinitis pigmentosa in USH patients exists so far. In addition, given the yet undefined functional role and expression of the different CLRN1 splice isoforms in the retina, non-causative therapies such as gene supplementation are unsuitable at this stage. In this study, we focused on the recently identified deep intronic c.254-649T>G CLRN1 splicing mutation and aimed to establish two causative treatment approaches: CRISPR-Cas9-mediated excision of the mutated intronic region and antisense oligonucleotide (AON)-mediated correction of mRNA splicing. The therapeutic potential of these approaches was validated in different cell types transiently or stably expressing CLRN1 minigenes. Both approaches led to substantial correction of the splice defect. Surprisingly, however, no synergistic effect was detected when combining both methods. Finally, the injection of naked AONs into mice expressing the mutant CLRN1 minigene in the retina also led to a significant splice rescue. We propose that both AONs and CRISPR-Cas9 are suitable strategies to initiate advanced preclinical studies for treatment of USH3A patients.
From Non-Reactive to Reactive Walking in Humanoid Robots (2018)

In this paper we report the implementation and the experimental validation of a controller to provide reactive walking gait capabilities of bipedal robots during the execution of predefined walking patterns. The proposed method is a cascade controller design to cope with external disturbances and to increase the robot stability. IMU states are used as inputs to generate modifications of the feet and the Center of Mass trajectories of the predefined walking gait. The method increases the walking stability minimizing the errors due to small terrain variations and external disturbances. The effectiveness of the proposed controller is validated in simulation and in real implementation on the full-body humanoid robot COMAN+.
Development and analytical performance of an automated screening method for cannabinoids on the Dimension clinical chemistry system (1997)

A fully automated, random access method for the determination of cannabinoids (UTHC) was developed for the Dimension AR and XL clinical chemistry systems. The method utilizes Abuscreen ONLINE reagents and a multianalyte liquid calibrator containing 11-nor-Delta(9)-THC-9-carboxylic acid. Within-run and total reproducibility, determined using NCCLS protocol EP5- T2, was less than 0.6% and 1.6% CV, respectively, at all concentrations. Calibration stability was retained for at least 30 days. An extensive evaluation of non-structurally related drugs and various physiological substances indicated lack of interference in the method. No sample carry-over was observed following a specimen containing 1886 ng/ml 11-nor-Delta(9)-THC-9-carboxylic acid. A 99.1% agreement (N = 445 samples) was found between an EMIT based method on the aca discrete clinical analyser and the Dimension UTHC method.Dimension clinical chemistry system and aca discrete clinical analyser are registered trademarks of Dade International.
A mutagen from histidine reacted with nitrite (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA mutagen from histidine reacted with nitriteGenichi. Danno, Kazuki. Kanazawa, Masaya. Toda, Masashi. Mizuno, Hitoshi. Ashida, and Masato. NatakeCite this: J. Agric. Food Chem. 1993, 41, 7, 1090–1093Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jf00031a015https://doi.org/10.1021/jf00031a015research-articleACS PublicationsRequest reuse permissionsArticle Views272Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MIMO adaptive control of thruster-firing-induced vibration of satellites using multifunctional platforms (2005)

This paper presents the concept, control strategy, and simulations of suppressing the thruster-firing-induced vibration of satellites. First, a satellite vibration reduction concept of utilizing the UHM multifunctional platform is discussed, and the structural configurations of the platform as well as the combination of the platform and a satellite are described. A satellite-like frame with the platform is analyzed, and the predominant modes of the frame are determined. A MIMO adaptive control scheme is then developed to suppress the frame vibration, and a convergence factor vector concept is introduced to ease the multi-channel convergence rate control. This controller is adjusted based on the vibration information of the frame and drives the platform to isolate the vibration transmission from the firing thruster to the satellite structure. The entire system has ten actuators: four piezoelectric stack actuators and six piezoelectric patch actuators. Eleven vibration components of the frame and platform are controlled. Nine components are in the frame for the satellite vibration suppression, and two are in the top-device plate of the platform for the thruster vibration suppression. Finally, simulations are performed to suppress the vibration of the frame for three platform positions to simulate the misalignment correction of the satellite thrust vector. The results demonstrate that the entire frame vibration at its dominant frequency decreases to 7-10% of its uncontrolled value in the three platform positions, and the thruster vibration decreases to 7.5% of its uncontrolled value.
P1‐001: Visual attention is decreased in aged dogs (2008)

Aged dogs, like aged humans, exhibit both deficits in learning and memory as well as brain pathology. We also have evidence of the canine cholinergic system becoming compromised with increased age, which may contribute to the age-dependent deficits in learning and memory. The present study sought to further analyze cognitive decline in aged dogs by focusing on performance on a test designed to assess attentional processes. We have previously used a three-choice discrimination task, called the oddity task, to study selective attention in dogs. In this task, we trained dogs to pick out the odd object (called the target) from a set of three objects where two of the objects presented were identical (called distracters). Typically, aged dogs perform similar to young dogs when asked to differentiate between only two objects that differ in three dimensions (size, color, and shape). For the oddity task, by contrast, we found that older dogs had more difficulty solving the task than young dogs. This deficit was enhanced when the similarity between objects was increased. The present study assessed the effect of increasing the number of distracters on performance of dogs of different ages. Consequently, we compared performance on both a 2- and 4-choice oddity task. Senior dogs were impaired on the 2-choice task compared to all other age groups. For the other groups, increasing age was positively correlated with number of errors in the 4-choice task, such that adult animals performed significantly better than middle aged, old and senior dogs. This finding lends further support to the dog as a model of human cognitive aging and also supports using aged dogs in screening cognitive-enhancing interventions and therapies targeted at human aging.
Studies of emission regions of the X-ray pulsar Hercules X-1 with pulse-phase-resolved spectra observed with Suzaku (2020)

Abstract Pulse-phase-resolved X-ray spectra of the X-ray pulsar Her X-1 observed with Suzaku are analyzed. The analysis is based on a hypothesis that the observed variations of the continuum spectra associated with the neutron star spin originate in the changes of the projection areas of the emission regions viewed from the observer, and that the spectral shape observed from each of the emission regions does not change with the viewing angle variation. We calculate the ratios of the fluxes in each energy bin between arbitrary pairs of the pulse-phase-resolved spectra over the entire energy range. We identify flat portions in these ratio spectra, which are likely to indicate the intrinsic emission components that have invariant spectral shapes, in the three energy bands of below ∼1 keV, 2–6 keV, and above ∼18 keV. Then, we approximately solve the simultaneous equations for the intrinsic spectral components from a pair of the phase-resolved spectra that show flat portions in the ratio spectrum. As a result, spectra of the three components are obtained as the low-, medium-, and high-energy bands corresponding to those for the flat portions. They are found to be well fitted with a soft blackbody, a cut-off power law, and a hard blackbody model, respectively. Finally, we fit all the phase-resolved spectra simultaneously with a composite model of three continuum components together with a cyclotron absorption feature and an iron line, and obtain an acceptable result. The origins of the cut-off power-law and hard blackbody components are discussed in relation to recently developed theoretical models.
Automation Potential of a New, Rapid, Microscopy-Based Method for Screening Drug–Polymer Solubility (2020)

For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches. This is also the case for selecting highly effective polymeric excipients for forming molecular dispersions in order to improve the dissolution and subsequent bio-availability of a poorly soluble drug. Previously, we developed a new thermal imaging-based rapid screening method, thermal analysis by structure characterization (TASC), which can rapidly detect the melting point depression of a crystalline drug in the presence of a polymeric material. In this study, we used melting point depression as an indicator of drug solubility in a polymer and further explored the potential of using the TASC method to rapidly screen and identify polymers in which a drug is likely to have high solubility. Here, we used a data bank of 5 model drugs and 10 different pharmaceutical grade polymers to validate the screening potential of TASC. The data indicated that TASC could provide significant improvement in the screening speed and reduce the materials used without compromising the sensitivity of detection. It should be highlighted that the current method is a screening method rather than a method that provides absolute measurement of the degree of solubility of a drug in a polymer. The results of this study confirmed that the TASC results of each drug-polymer pair could be used in data matrices to indicate the presence of significant interaction and solubility of the drug in the polymer. This forms the foundation for automating the screening process using artificial intelligence.
Breaking down the walls (2006)

The current changes and continuing debate about future primary care services, primary care trusts (PCTs) and acute hospitals and Foundation Trusts in England need to take into account the growing number of practitioners and services providing specialist care in non-hospital settings.
[Development of connective tissue in mouse skeletal muscle]. (1986)

The development of the connective tissue in the dorsal forelegs of mouse embryos and sucklings was investigated with the aid of immunofluorescence and electron microscopy. Collagen type III is visible earlier in the muscular connective tissue than collagen type I. However, it seems that collagen does not play a fundamental role in the organization of the muscular tissue. The occurrence of collagen is rather an indication of the mechanical development of the muscles. In early embryos (day 13 to day 15) some desmosome-like cell contacts are visible between fibroblasts and myoblasts, as well as myotubes.
Effects of control systems time delay on the performance of direct harmonics elimination [power network active filters] (2004)

Active filters are power electronic systems that absorb the harmonic currents in a network, produced by nonlinear loads or apparatus such as high-voltage-direct-current (HVDC) converters. Active filters can be classified into two categories, based on their underlying control methods. The performance of the active filter can be adversely affected by control and measurement delays in the controls. This paper investigates the effects of control circuit time delay on the performance of direct harmonic elimination. Using analytical and transient simulation, this paper investigates the impact of this delay when the filter is based on the 'direct' method.
Interleukin-1β Messenger Ribonucleic Acid and Protein Levels after Fluid-Percussion Brain Injury in Rats: Importance of Injury Severity and Brain Temperature (2002)

Injury severity determines the degree of IL-1beta protein level elevation after TBI. The effects of posttraumatic hypothermia on IL-1beta protein levels (an important mediator of neurodegeneration after TBI) may partly explain the established effects of posttraumatic temperature manipulations on inflammatory processes after TBI.
ChemInform Abstract: Total Synthesis of Fostriecin (CI‐920). (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gelatin-Based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro (2014)

Due to the weak regeneration potential of cartilage, there is a high clinical incidence of articular joint disease, leading to a strong demand for cartilaginous tissue surrogates. The aim of this study was to evaluate a gelatin-based hydrogel for its suitability to support chondrogenic differentiation of human mesenchymal stem cells. Gelatin-based hydrogels are biodegradable, show high biocompatibility, and offer possibilities to introduce functional groups and/or ligands. In order to prove their chondrogenesis-supporting potential, a hydrogel film was developed and compared with standard cell culture polystyrene regarding the differentiation behavior of human mesenchymal stem cells. Cellular basis for this study were human adipose tissue-derived mesenchymal stem cells, which exhibit differentiation potential along the adipogenic, osteogenic and chondrogenic lineage. The results obtained show a promotive effect of gelatin-based hydrogels on chondrogenic differentiation of mesenchymal stem cells in vitro and therefore encourage subsequent in vivo studies.
Describing Uncertainty in Dynamical Systems by Uncertain Restrictions (1991)

A recently developed mathematical theory of hints is applied to analyze dynamic systems and to solve smoothing, filtering and prediction problems. This theory is strongly related to the mathematical theory of evidence proposed by Shafer and Dempster for problems of statistics and reasoning under uncertainty. The uncertain systems dynamics is described by an uncertain relation between system states at subsequent times, or equivalently, by an uncertain inclusion of the next state given the actual state. Similarly, the uncertain state observation mechanism is also represented by an uncertain relation between state and observation. These uncertain relations constitute hints or random sets. The model includes both system with stochastic disturbances as well as systems with unknown but bounded disturbances as special cases. Dempster’s rule is used to extract information — given the model and a series of observations — related to the system state at a prescribed time point. This leads to a new and unifying approach to develop filtering, prediction and smoothing schemes for the whole class of uncertain systems represented by the model. Aknowledgements. This work was in part done during a visit to the University of Padova, Italy, supported by the ConsigUo Nazionale Delia Ricerche, Groupo Nazionale per L’Analisi Funzionalee le sue Apphcazione.
Synchronizers based on carrier phase lock Loop and on symbol phase lock loop (2008)

The symbol synchronizer recoveries the clock and after, with it, samples and retimes the data. We present two synchronizer groups, the first based on filter with carrier phase lock loop (CPLL) and the second based on symbol phase lock loop (SPLL). Each group has four prototypes namely the analog, the hybrid, the combinational and the sequential. The objective is to study the various synchronizers output jitter UIRMS (unit interval root mean squared) as function of the input SNR (Signal to Noise Ratio).
An overview of system software for the KSR 1 (2002)

The author describes the KSR 1 system software and its role in bringing the benefits of programmability and scalability to the user. The system software consists of KSR OS, a UNIX compatible operating system, the preprocessors and compilers that comprise the language system, and the parallel programming tools that provide analysis and synthesis support to the parallel programmer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
AuCo/TiO2-NTs Anode Catalysts for Direct Borohydride Fuel Cells (2016)

Gold-cobalt catalysts deposited on titania nanotubes surface (denoted as AuCo/TiO2-NTs) are studied as possible anode materials for direct borohydride/hydrogen peroxide fuel cells. The morphology and composition of the catalysts is characterized by field emission scanning electron microscopy and by inductively coupled plasma optical emission spectroscopy. The fuel cell measurements are performed at four temperatures, in the 25–55°C range, on a lab-scale direct alkaline NaBH4-H2O2 single fuel cell. Polarization curves are recorded to evaluate the fuel cell performance using each prepared anode catalyst. The peak power density dependence on temperature is in the 87–102 mWcm−2 range for Co/TiO2-NTs catalyst and in the 163–283 mWcm−2 range for the AuCo/TiO2-NTs catalysts with Au loadings ranging from 10 to 60 μgAucm−2. The present results demonstrate that power density is raised by over 150% due to the use of AuCo/TiO2-NTs as anode catalysts.
THERMOREGULATORY RESPONSE OF WOMEN TO INTERMITTENT WORK IN THE HEAT (1976)

Drinkwater, B. L.; Denton, J. E.; Raven, P. B.; Horvath, S. M.; Drinkwater, Barbara L. Author Information
Low-Density Lipoprotein e (LDL) Distribution Shown by 99mTechnetium-LDL Imaging in Patients with Myeloproliferative Diseases (1989)

These results indicate that spleen and bone marrow are sites of LDL catabolism in patients with myeloproliferative disease and suggest the role of macrophages in the hypocholesterolemia and accelerated LDL catabolism of myeloproliferative disease.
Development of a Flickermeter for Grid-Connected Wind Turbines Using a DSP-Based Prototyping System (2006)

The measurement of one of the power-quality problems (flicker), which may arise due to the presence of wind-turbine generators, is presented. This paper focuses on the design of a complete fully digital flickermeter relying on an in-house-developed measurement system, which features a data-acquisition system, using a C6711 DSP-based starter kit (DSK) and a field programmable gate array (FPGA). To study flicker produced during the wind turbine's continuous operation, special attention is given to the simulation of the voltage fluctuations on a fictitious grid.
Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots of Panax japonicus (2016)

Three new polyacetylenic oleanane-type triterpenoids, baisanqisaponins A-C (1-3), and one new oleanane-type triterpenoid, chikusetsusaponin-V ethyl ester (4), together with 19 known compounds (5-23), were isolated from the roots of Panax japonicus. The structures were elucidated on the basis of spectroscopic analyses and chemical methods. Compounds 1-3 feature a rare panaxytriol group containing a polyacetylene on the saponin skeleton. Neuroprotective activity was evaluated for compounds 1-17, and angiotensin II-induced vascular smooth muscle cell proliferation inhibition was tested for compounds 5-7 and 10-12.
5. Membrane separation processes (2019)

The success of two membrane processes, reverse osmosis and ultrafiltration, has helped make membrane processes a central technique in solving separation problems for fluid systems. This book discusses the various applications and developments in membrane technology and shows how accurate membrane processes can be designed. Starting with the local transport phenomena, the behavior of individual elements such as tube or plate membrane and the behavior of the technical unit - the module - are discussed in detail. The book goes on to demonstrate the most effective ways of arranging modules for forming an optimal plant.