gebhart/patrepeval huggingface dataset:
Various Passport Options and Their Valuation (1999)

. The passport option is a call option on the balance of a trading account. The option holder retains the gain from trading, while the writer is liable for the loss. We establish pricing equations for various passport options including the multi-asset passport and those with discrete trading constraints. The results are typically known as the HamiltonJacobi -Bellman equations and multiple layers of free boundary partial differential equations for a sequence of optimal stopping times. Also we examine the gain by selling passport options to utility maximising investors and to investors who guess the market from imperfect information. 1 1 Introduction Market participants trade risky assets for better returns, at least on average. As long as the risk remains significant, however, investment in these assets does not guarantee a positive payoff and traders are prone to become a victim of their own strategies. Nowadays, a variety of financial instruments allow traders to generate non-linea...
Investigating the potential for a limited quantum speedup on protein lattice problems (2021)

Protein folding, the determination of the lowest-energy configuration of a\nprotein, is an unsolved computational problem. If protein folding could be\nsolved, it would lead to significant advances in molecular biology, and\ntechnological development in areas such as drug discovery and catalyst design.\nAs a hard combinatorial optimisation problem, protein folding has been studied\nas a potential target problem for adiabatic quantum computing. Although several\nexperimental implementations have been discussed in the literature, the\ncomputational scaling of these approaches has not been elucidated. In this\narticle, we present a numerical study of the (stoquastic) adiabatic quantum\nalgorithm applied to protein lattice folding. Using exact numerical modelling\nof small systems, we find that the time-to-solution metric scales exponentially\nwith peptide length, even for small peptides. However, comparison with\nclassical heuristics for optimisation indicates a potential limited quantum\nspeedup. Overall, our results suggest that quantum algorithms may well offer\nimprovements for problems in the protein folding and structure prediction\nrealm.
IgG Antibodies to Bovine Serum Albumin Are Not Increased in Children With IDDM (1995)

IgG antibodies to bovine serum albumin (BSA) were measured in 91 serum samples from children 4-17 years of age with newly diagnosed insulin-dependent diabetes mellitus (IDDM). A total of 80 healthy 12-year-old children served as control subjects. BSA antibody values > 3 SDs were obtained in 6 IDDM patients and 3 control subjects (P = 0.50), and values > 2 SDs were obtained in 12 IDDM patients and 4 control subjects (P = 0.11). In conclusion, IgG antibodies to BSA were not significantly increased at onset of diabetes.
The Influence of Obstetric Factors on the Occurrence of Pelvic Floor Dysfunction in Women in the Early Postpartum Period (2022)

Fan Yang,1 Hongyu Liao2 1Department of Surgery, Huazhong University of Science and Technology Hospital, Wuhan, Hubei, 430074, People’s Republic of China; 2Department of Obstetrics and Gynecology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, 430074, People’s Republic of ChinaCorrespondence: Hongyu Liao, Department of Obstetrics and Gynecology, Hubei Provincial Hospital of Traditional Chinese Medicine, No. 856, Luoyu Road, Wuhan, Hubei, 430074, People’s Republic of China, Tel +86-18086669896, Email liaohongyu96@126.comBackground: This study aimed to analyze the effect of obstetric factors on the development of pelvic floor dysfunction (PFD) in women in the early postpartum period.Methods: Clinical data of 300 women who were reviewed in our outpatient clinic from July 2016 to December 2019 in the postpartum period were retrospectively analyzed. The occurrence of pelvic organ prolapse (POP) and stress urinary incontinence (SUI) was assessed using the Pelvic Organ Prolapse Quantification System and International Consultation on Incontinence Questionnaire Short Form. Factors affecting the occurrence of PFD in women in the early postpartum period were analyzed using univariate and multifactorial logistic regression models.Results: A total of 46 cases of POP (15.33%) and 82 of SUI (27.33%) occurred in 300 women at 6– 8 weeks after birth. Unconditional logistic regression confirmed that age ≥ 35 years, vaginal delivery, BMI before delivery ≥ 25 kg/m2, perineal tear, protracted or prolonged second stage of labor, and fetal macrosomia were risk factors influencing the occurrence of POP (OR > 1, P < 0.05), whereas age ≥ 35 years, vaginal delivery, perineal tear, protracted or prolonged second stage of labor, fetal macrosomia, and SUI during pregnancy were risk factors influencing the occurrence of SUI (OR> 1, P< 0.05).Conclusion: Obstetric factors such as age, mode of delivery, perineal tear, protracted or prolonged second stage of labor, and fetal macrosomia may increase the risk of developing PFD in women in the early postpartum period; hence, these risk factors should be correctly identified and promptly addressed to prevent the development of PFD.Keywords: pelvic floor dysfunction, pelvic organ prolapse, stress urinary incontinence, obstetric factors
Motori High-Tech prestazionali: c'è un ruolo per i due tempi? (1998)

Con riferimento alle diverse soluzioni proponibili, vengono mostrati vantaggi e svantaggi che caratterizzano i motori a due tempi rispetto ai quattro tempi per applicazioni in auto e motoveicoli, tenendo presentì le possibilità offerte dai recenti progressi nel campo dell’iniezione sia per motori ad accensione comandata che in quelli ad accensione per compressione.&#13;&#13;\nPer diversi impieghi, oltre a quello ovvio dei piccoli motoveicoli, i due tempi sono potenzialmente competitivi o vincenti rispetto ai quattro tempi, in particolare appaiono vantaggiosi per i piccoli autoveicoli prestazionali.
Quantitative immunohistologic criteria are superior to the lymphocytic focus score criterion for the diagnosis of Sjögren's syndrome (1992)

Quantitative immunohistologic criteria were shown to be much more sensitive and disease specific than the widely accepted grade IV lymphocytic adenitis criterion, which corresponds to a lymphocytic focus score greater than 1, and these criteria should be included in the international diagnostic criteria for Sjögren's syndrome.
Neutrophil Modulation of the Pulmonary Chemokine Response to Lipopolysaccharide (2002)

When cells within the intrapulmonary compartment are exposed to pathogens or their products such as lipopolysaccharide, they produce CXC chemokines in order to attract circulating neutrophils into the lower respiratory tract. Previous studies have shown that as neutrophils (PMNs) enter the lung, bronchoalveolar lavage (BAL) chemokine levels are decreased. In this study, we determined the intrapulmonary and systemic responses to two important rat chemokines, cytokine-induced neutrophil chemoattractant (CINC) and macrophage inflammatory protein-2 (MIP-2), to intratracheal (i.t.) LPS (100 microg in 0.5 mL of phosphate-buffered saline) under neutropenic (cyclophosphamide [CPA]) and neutrophilic (G-CSF) conditions. By 4 h after i.t. LPS, CPA pretreatment decreased PMN recruitment 83% and G-CSF increased PMN recruitment 91% compared with recruitment into the lung in vehicle-pretreated rats (42.7 +/- 19.3 million PMNs). Neutropenic rats had increased CINC and MIP-2 concentrations in BAL fluid 4 h after i.t. LPS when compared with levels seen in vehicle controls (P < 0.05). In vitro LPS-stimulated chemokine production by alveolar macrophages obtained from CPA- and vehicle-pretreated animals did not differ. The increase in BAL fluid chemokine levels in neutropenic rats corresponded to increased chemotaxis of neutrophils to BAL fluid from CPA-pretreated rats as compared with the chemotaxis response of PMN to BAL fluid from vehicle-pretreated rats. In contrast, G-CSF enhancement of neutrophil recruitment decreased chemotactic activity of BAL fluid collected 4 h after i.t. LPS. These data show that as neutrophils are recruited into the lung, they alter chemokine levels, which most likely serves to down-regulate the inflammatory response.
r-regular shape reconstruction from unorganized points (1997)

In thw paper, the problem of reconstructing a surface, given a set of scattered data points is addressed. First, a precise formulation of the reconstruction problem is proposed. The solution is mathematically defined as a particular mesh of the surface called the normalized mesh. This solution has the property to be included inside the Delaunay graph.
Novel method of micro bubble manipulation by self organization in ultrasonic wave (2005)

A novel method for micro bubble manipulation by ultrasonic waves is proposed. This method uses seed bubbles in order to manipulate the target bubbles. First, if the seed bubbles are introduced into an incident ultrasonic wave field, they start to oscillate, radiating secondary ultrasonic waves around them. These waves produce Bjerknes force between the bubbles. This produces seed bubble aggregation with a certain size. Then, the target bubbles are introduced, the Bjerknes force between the aggregated seed bubbles and the target bubbles trap the target bubbles, producing a bi-layer bubble mass of (inner layer: seed bubbles, outer layer: target bubbles). Experiments are carried out using bubbles with PVC shells. It is observed that the target bubbles, which are not trapped when they flow into the ultrasonic wave field, are trapped as a bi-layer bubble mass by the proposed method.
Diagnosis and grading of chondrosarcomas on FNA biopsy material (2002)

A consecutive series of 47 chondrosarcomas was reviewed to identify the most useful criteria for cytological diagnosis, and grading in comparison to histology grade. This series includes 39 evaluable cases, including 2 patients with Ollier's disease and 2 with extraskeletal chondrosarcomas. Eight cases were excluded because of lack of histologic confirmation (3). nondiagnostic cytology (4). and one inconclusive histologic diagnosis. The cytologic diagnosis of these tumors was based on the identification of chondrocytes and a chondromyxoid stroma. The chondrocytes often showed double nuclei (34/39) and macronucleoli (20/39). Nuclear atypia in terms of distinct variation in size was less common (16/39). Cytoplasmic granules and vacuoles were often seen (34/39 and 29/39, respectively). In smears, chondroid fragments and a chondromyxoid background were seen in a majority of cases (36/39 and 30/39, respectively). By grade, concordance with histology was present in 4/7 grade I tumors, 26/29 grades II-III, and 5/5 grade IV, respectively.
Longitudinal Control Of A Platoon Of Vehicles. III, Nonlinear Model (1990)

This paper presents a systematic analysis of a longitudinal control law for a platoon of non-identical vehicles using a non-linear model for the vehicle dynamics.
Cyclic Fatigue Crack Growth In PZT Piezoelectric Ceramics Induced By Mechanical Load (2004)

In this work the crack propagation behaviour of a commercially obtained lead zirconate titanate (PZT) piezoceramic is studied under monotonic and cyclic loading. Piezoelectric ceramics contain an electrical dipole in their crystal structure such that when a mechanical load is applied an electrical potential is formed, and vice versa. Permanent electrical domain orientation may be induced by the application of a large electrical potential in a process known as poling. Piezoelectric ceramics are used for applications such as actuators, sonar transducers and microphones. These and most other application involve high levels of cyclic loading and fatigue degradation is will known. However, cyclic fatigue to date has only been considered under electrical loading despite the fact that most components are subjected to high levels of mechanical load. Crack growth studies are rare. In the vicinity of a crack tip, local stress causes switching of the crystal domains leading to dilation perpendicular to the crack propagation direction. This explains the observed crack growth resistance (R-curve) toughening which is characterised in this work. Furthermore, it is shown that the extent of toughening is dependent upon the crack propagation direction relative to the poling direction. When a cyclic mechanical load is applied, subcritical crack growth is shown to occur below the plateau value of the R-curve and at rates which are independent of poling direction. A measurement of static fatigue rates show that a true cyclic fatigue degradation process exists. Another experiment which measured the R-curve behaviour as a function of intermittent loading time showed that the observed fatigue behaviour could not be explained by reverse switching of the crystal domains. The question arises therefore as to the mechanism of cyclic fatigue degradation in PZT and whether it is the same under both cyclic electrical and mechanical loading. In both cases it is currently unknown however a parallel study has shown that plastic strain accumulates in bulk PZT under mechanical loading in a strain-softening type process. The link between this and crack propagation behaviour will be discussed.
A patient with AL amyloidosis with negative free light chain results (2015)

The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 after syncope and the identification of left ventricular hypertrophy at echocardiography, suspected for amyloidosis. A commercial agarose gel electrophoresis immunofixation (IFE) did not reveal monoclonal components in serum and urine. The κ serum free light chain (FLC) concentration was 21.5 mg/L, λ 33 mg/L (κ/λ ratio 0.65), NT-proBNP 9074 ng/L (u.r.l. <332 ng/L) and an echocardiogram confirmed characteristic features of amyloidosis. The abdominal fat aspiration was positive and the amyloid typing by immune-electron microscopy revealed λ light chains deposits. A high-resolution (hr) IFE of serum and urine showed a faint monoclonal λ component in the urine. A bone marrow biopsy showed 8% plasma cells (BMPC) and a kappa/lambda light-chain restriction with λ light chain on immunofluorescence. The diagnosis of AL (λ) amyloidosis with cardiac involvement was made. In May 2013, patient was started on cyclophosphamide, bortezomib and dexamethasone. After six cycles, serum and urine hr-IFE were negative, the bone marrow biopsy showed 3% BMPC without light chain restriction by immunofluorescence, and a decrease of NT-proBNP was observed (5802 ng/L).Thus, treatment was discontinued. In this patient the amyloid clone could be detected only by in house hr-IFE of urine and bone marrow examination. The detection of the small dangerous amyloidogenic clone should be pursued with a combination of high-sensitivity techniques, including assessment of BMPC clonality. Studies of novel tools, such as mass spectrometry on serum and next-generation flow cytometry analysis of the bone marrow, for detecting plasma cell clones in AL amyloidosis and other monoclonal light chain-related disorders are warranted.
Transcriptional activation in an improved whole-cell extract from Saccharomyces cerevisiae. (1991)

We report an improved in vitro transcription system for Saccharomyces cerevisiae. Small changes in assay and whole-cell extraction procedures increase selective initiation by RNA polymerase II up to 60-fold over previous conditions (M. Woontner and J. A. Jaehning, J. Biol. Chem. 265:8979-8982, 1990), to levels comparable to those obtained with nuclear extracts. We have found that the simultaneous use of distinguishable templates with and without an upstream activation sequence is critical to the measurement of apparent activation. Transcription from any template was very sensitive to the concentrations of template and nontemplate DNA, extract, and activator (GAL4/VP16). Alterations in reaction conditions led to proportionately greater changes from a template lacking an upstream activation sequence; thus, the apparent ratio of activation is largely dependent on the level of basal transcription. Using optimal conditions for activation, we have also demonstrated activation by a bona fide yeast activator, heat shock transcription factor.
Programmed disorders of β-cell development and function as one cause for type 2 diabetes? The GK rat paradigm (2005)

Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential tools for identification of genes and environmental factors that increase the risk of abnormal beta-cell function and of T2DM. The information available in the Goto-Kakizaki (GK) rat, one of the best characterized animal models of spontaneous T2DM, are reviewed in such a perspective. We propose that the defective beta-cell mass and function in the GK model reflect the complex interactions of three pathogenic players: (1) several independent loci containing genes causing impaired insulin secretion; (2) gestational metabolic impairment inducing a programming of endocrine pancreas (decreased beta-cell neogenesis) which is transmitted to the next generation; and (3) secondary (acquired) loss of beta-cell differentiation due to chronic exposure to hyperglycemia (glucotoxicity). An important message is that the 'heritable' determinants of T2DM are not simply dependant on genetic factors, but probably involve transgenerational epigenetic responses.
Influencia de los áridos reciclados de residuos de construcción y demolición en la adhesividad de mezclas bituminosas (2009)

Este congreso, organizado pola Universidade do Minho e a Universidade de Coimbra, tivo lugar en Lisboa, do 22 ao 27 de novembro de 2009.
Case Report: An early-onset inflammatory colitis due to a variant in TNFAIP3 causing A20 haploinsufficiency (2022)

Autoinflammatory diseases (AID) are a heterogeneous group of inherited conditions caused by abnormal activation of systems mediating innate immunity. Recent literature focuses on A20 Haploinsufficiency, an autoinflammatory disease with a phenotype resembling Behçet disease (BD). It is caused by <i>loss-of-function</i> mutations in <i>TNFAIP3</i> gene that result in the activation of a pro-inflammatory pathway. In this case report we describe a one-year-old baby who came to our attention for hematochezia appeared at three months of age which was considered an expression of early-onset colitis. The following appearance of cutaneous inflammation Behçet-like and the positive family history concurred with the diagnosis of an autoinflammatory disease. Extended genetic tests in the patient allowed to identify a heterozygous variant in <i>TNFAIP3</i> [NM_006290.4:c.460G > T, p.(Glu154Ter)], not previously described and not present in the GnomAD database. As a consequence the diagnosis A20 Haploinsufficiency was established and the appropriate management was started. The same <i>TNFAIP3</i> variant was also found in her father who had suffered from recurrent oral aphthosis, vitiligo and thyroiditis since childhood. In conclusion, we described a young patient with a novel heterozygous mutation in <i>TNFAIP3</i> who developed BD-like symptoms. We proposed that loss-of-function variants in <i>TNFAIP3</i> may be associated with a very early-onset intestinal BD phenotype.
A comparative study of the efficacy of H2 receptor antagonist, prokinetics, and mucosal protective agents in improving cyclosporine-induced gastrointestinal complications (2017)

Background: Cyclosporine (CS) has been used successfully for various skin diseases. However, sometimes it is difficult to manage patients due to its adverse events, especially gastrointestinal (GI) discomforts in their clinical practices.
Objectives: The aim of this study was to compare the effectiveness of three GI agents for improving CS-induced GI complications.
Methods: We performed a prospective study of 60 patients with CS-induced GI complications. The participants were randomly assigned to receive H2 receptor antagonist (H2RA), prokinetics, or mucosal protective agents (MPA), each of 20 patients. Changes in severity of GI symptoms were evaluated by a validated GI Symptom Rating Scale (GSRS) and Dyspepsia Symptom Severity Index (DSSI) at baseline and at 2 and 4 weeks after treatment.
Results: All the medications significantly improved GSRS and DSSI after 2- and 4-week of treatment compared with baseline except that 2-week treatment with prokinetics didn’t improve GSRS. There was no significant difference in effectiveness among the medications but GSRS of the 2-week treatment with MPA was better than that of prokinetics (p=0.046).
Conclusion: We confirmed CS-induced GI complications were effectively treated with practical GI agents including H2RA, prokinetics, and MPA. However, considering that prokinetics needs more time to have symptomatic relief, H2RA and MPA would be preferred as practical option to maintain patients’ compliance.
Temperatur-Konzentrations-Schnitte in ternären und quaternären Systemen entlang Kurven oder Flächen doppelt gesättigter Schmelzen (1969)

Article Temperatur-Konzentrations-Schnitte in ternären und quaternären Systemen entlang Kurven oder Flächen doppelt gesättigter Schmelzen was published on May 1, 1969 in the journal International Journal of Materials Research (volume 60, issue 5).
[Neuropathic pain unrelieved by morphine, alleviated by haloperidol]. (1990)

Neuropathic pain, originating in damaged nerve and not peripheral nociceptors, is often resistant to treatment by opiates given by the oral, parenteral or spinal routes. This failure to obtain satisfactory pain relief is generally ascribed to psychological factors or to individual peculiarities in drug metabolism or kinetics. Currently, psychotropic and antidepressant drugs are among the first choices in treating painful conditions due to partial nerve lesions. We present a 56-year-old man who suffered intractable pain confined to his left knee following emergency L2-3 vertebral decompression, after collapse due to metastatic disease. 12 mg of morphine and 10 of diazepam given together intravenously did not lessen pain. Acute, solitary spinal nerve root injury was hypothesized. 2 mg of haloperidol injected IV gave complete relief of pain without hypotension or deep sedation. There is no definite explanation for the resistance of neuropathic pain to opiates.
Paving the Way for Hybrid Teaching in Higher Education: Lessons from Students’ Perceptions and Acceptance of Different Teaching Modes during and after the Pandemic (2023)

The COVID-19 pandemic dramatically changed the higher education landscape, increasing dramatically the acceptance of online and hybrid teaching modes in higher education. The present paper addresses the question on how these teaching modes developed during the pandemic can contribute to enhance traditional teaching experiences in the context of higher education in renewable energy master level courses from the perspective of the students. The main focus of the study lies on the student perception of their learning experience in the different course delivery modes. Additionally, the role of some didactic activities and materials as a complement for enhancing the learning experience in the different teaching modes is investigated. For this purpose, we evaluated several courses delivered in different teaching modes and interviewed students to characterize their perceptions on their learning experience in each of them. Main criteria for the student’s evaluation were the efficacy, workload or motivation and engagement perceived in the different course designs. Results show a high student’s acceptance and suitability of the proposed teaching method as compared to online and traditional face to face teaching modes.