gebhart/patrepeval huggingface dataset:
Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter Trial (1988)

Following promising preliminary evidence, the benzodiazepine-derivative alprazolam was studied in a large, placebo-controlled, eight-week, flexible-dose trial in patients with agoraphobia with panic attacks and panic disorder. Of 526 patients, 481 completed three weeks of treatment; however, significantly more placebo (102/234) than alprazolam (21/247) recipients subsequently dropped out of the trial, primarily citing ineffectiveness (of placebo) as the reason. Alprazolam was found to be effective and well tolerated. There were significant alprazolam-placebo differences in improvement for (1) spontaneous and situational panic attacks, (2) phobic fears, (3) avoidance behavior, (4) anxiety, and (5) secondary disability, all significant by the end of week 1. At the primary comparison point (week 4), 82% of the patients receiving alprazolam were rated moderately improved or better vs 43% of the placebo group. At that point, 50% of the alprazolam recipients vs 28% of placebo recipients were free of panic attacks.
Prompt D0, D+, and D*+ production in Pb–Pb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV (2022)

A bstract The production of prompt D 0 , D + , and D *+ mesons was measured at midrapidity (| y | &lt; 0.5) in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair $$ \sqrt{s_{\mathrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 5 . 02 TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decay channels and their production yields were measured in central (0–10%) and semicentral (30–50%) collisions. The measurement was performed up to a transverse momentum ( p T ) of 36 or 50 GeV/c depending on the D meson species and the centrality interval. For the first time in Pb–Pb collisions at the LHC, the yield of D 0 mesons was measured down to p T = 0, which allowed a model-independent determination of the p T -integrated yield per unit of rapidity (d N/ d y ). A maximum suppression by a factor 5 and 2.5 was observed with the nuclear modification factor ( R AA ) of prompt D mesons at p T = 6–8 GeV/c for the 0–10% and 30–50% centrality classes, respectively. The D-meson R AA is compared with that of charged pions, charged hadrons, and J /ψ mesons as well as with theoretical predictions. The analysis of the agreement between the measured R AA , elliptic ( v 2 ) and triangular ( v 3 ) flow, and the model predictions allowed us to constrain the charm spatial diffusion coefficient D s . Furthermore the comparison of R AA and v 2 with different implementations of the same models provides an important insight into the role of radiative energy loss as well as charm quark recombination in the hadronisation mechanisms.
Fault diagnosis and failure prognosis for engineering systems: A global perspective (2009)

Engineering systems, such as aircraft, industrial processes, manufacturing systems, transportation systems, electrical and electronic systems, etc., are becoming more complex and are subjected to failure modes that impact adversely their reliability, availability, safety and maintainability. Such critical assets are required to be available when needed, and maintained on the basis of their current condition rather than on the basis of scheduled or breakdown maintenance practices. Moreover, on-line, real-time fault diagnosis and prognosis can assist the operator to avoid catastrophic events. Recent advances in Condition-Based Maintenance and Prognostics and Health Management (CBM/PHM) have prompted the development of new and innovative algorithms for fault, or incipient failure, diagnosis and failure prognosis aimed at improving the performance of critical systems. This paper introduces an integrated systems-based framework (architecture) for diagnosis and prognosis that is generic and applicable to a variety of engineering systems. The enabling technologies are based on suitable health monitoring hardware and software, data processing methods that focus on extracting features or condition indicators from raw data via data mining and sensor fusion tools, accurate diagnostic and prognostic algorithms that borrow from Bayesian estimation theory, and specifically particle filtering, fatigue or degradation modeling, and real-time measurements to declare a fault with prescribed confidence and given false alarm rate while predicting accurately and precisely the remaining useful life of the failing component/system. Potential benefits to industry include reduced maintenance costs, improved equipment uptime and safety. The approach is illustrated with examples from the aircraft and industrial domains.
Mammalian urinary bladder permeability is altered by cationic proteins: modulation by divalent cations (1994)

It was previously demonstrated that protamine sulfate (PS, a cationic polypeptide) as well as synthetic cationic polypeptides (CpP, e.g., polylysine and polyarginine) caused an increase in the apical membrane conductance of the mammalian urinary bladder epithelium that was voltage dependent. The membrane conductance induced by these CpP was mediated by a saturable binding site and was partially blocked by CpP (self-inhibition). The PS-induced membrane conductance can be modified by polyvalent cations at three sites. The first site was to competitively inhibit the interaction of PS with an apical membrane binding site. The second site was to reversibly block the conductance induced by PS. The relative binding affinity (block of PS-induced conductance) sequence was as follows: UO2(2+) > La3+ > Mn2+ > Ba2+ > or = Ca2+ > Sr2+. Although La3+, Mn2+, Ba2+, Ca2+, and Sr2+ inhibited > or = 81% of the PS-induced conductance, UO2(2+) inhibited only 51% and Mg2+ was without effect. The third site was to increase the rate of loss of the PS-induced conductance from the apical membrane. Although neither carbodiimides (carboxyl group reactive reagents) nor neuraminidase (cleaves sialic acid residues) altered the effect of PS on the urinary bladder conductance, PS increased the conductance of lipid bilayers composed of negatively charged phospholipids. A candidate for the binding site might be the negatively charged phosphate groups of membrane lipids.
Progress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer (2014)

The combination of radiotherapy and targeted therapy is an important approach in the application of targeted therapy in clinical practice, and represents an important opportunity for the development of radiotherapy itself. Numerous agents, including epidermal growth factor receptor, monoclonal antibodies, tyrosine kinase inhibitors, and antiangiogenic therapies, have been used for targeted therapy. A number of studies of radiotherapy combined with targeted therapy in non-small-cell lung carcinoma have been completed or are ongoing. This paper briefly summarizes the drugs involved and the important related clinical research, and indicates that considerable progress has been made with the joint efforts of the two disciplines. Many issues, including drug selection, identification of populations most likely to benefit, timing of administration of medication, and side effects of treatment require further investigation. However, further fundamental research and accumulation of clinical data will provide a more comprehensive understanding of these therapies. Targeted therapy in combination with radiotherapy has a bright future.
The Use of Heart Rate for the Assessment of Firefighter Resilience: A Literature Review (2018)

Heart rate monitoring of the firefighters have begun to be used for job stress level assessment or firefighting training. However, resilience assessment and heart rate variability monitoring is not widely utilized on firefighters with limited feedback available through wearables. This paper presents an initial exploratory study that considers heart rate responses from firefighters in real life like emergency scenarios.
Ground based radar modulator solid-state upgrade (2012)

A ground based radar modulator driving a twystron microwave amplifier has been designed, built and tested. It is a solid-state upgrade replacing a thyratron-based line-type modulator, including a shunt regulated resonant charge power supply and a pressurized SF6 insulated pulse transformer tank. The upgraded modulator is a high-current thyristor based line-type modulator with a command charge switching power supply and an oil-filled pulse transformer and socket assembly tank. The modulator produces a 117 kV, 80 A, 7.1 μs flat top pulse with 25 kW average beam power and is driven by a 400 Hz 208 V generator. The modulator is compact and the design is modular and interlocked for ease of maintenance and improved safety. This paper will provide details of modulator performance including operating data, output waveforms and environmental test results.
VisualChat: A Visualization Tool for Human-Machine Interaction (2008)

This paper proposes a technique to analyze and visualize the human-machine interaction corpus using VisualChat. The evaluation used in this study is based on real-time interaction between machines or software robots called AINI (Artificial Intelligent Natural Language Identity) and online human user using MSN messenger, a Web-based messaging system called MSNChat. The result shows that VisualChat is a useful tool to evaluate the human-machine interaction corpus.
Check‐node lazy scheduling approach for layered belief propagation decoding algorithm (2014)

A novel check‐node lazy scheduling (CLS) approach is presented for the layered belief propagation (LBP) decoding algorithm in low‐density parity‐check (LDPC) applications. In the cases where the check nodes are highly reliable, this proposed CLS approach skips the check nodes in the belief propagation processes, and thus it clearly reduces the iteration times of LDPC decoding. Simulations show that, when this CLS approach is integrated into the classical LBP decoding algorithm, the needed maximum iterations is improved by nearly 30%.
Harvesting canning tomatoes: Survey indicates immediate savings in labor requirements and harvesting costs possible by use of improved methods (1952)

Immediate reductions in labor requirements and the cost of harvesting canning tomtoes—by 20% to 30%—are possible.
12주간의 유산소성 운동 트레이닝이 휴식 시, 음식 섭취 후 및 최대하 운동 후 회복기 중의 인슐린 민감도에 미치는 영향 (2002)

본 연구에서는 12주간의 유산소성 운동 트레이닝이 다양한 상황, 즉 휴식시, 음식 섭취 후, 그리고 최대하 운동 후 회복기에 측정한 인슐린 민감성에 미치는 영향을 규명하고자 하였다. 건강하고 트레이닝을 받은 바 없는 18~32세의 남자 19명이 피검자로 참가하였으며, 그들은 운동 트레이닝 집단 (EX: 9명)과 통제 집단 (CON: 10명) 중의 하나로 무선할당되었다. 사전검사 (PRE)의 첫날 체지방률과 최대산소섭취량을 측정하였고, 둘째 날에는 휴식시와 음식섭취 후 120분간 인슐린과 혈당 측정을 위하여 혈액을 채취하였다. 세번째 날에는 최대산소섭취량의 70%에서 30분간 운동을 한 후 120분간 회복하는 동안 역시 혈액을 채취하였다. 사전검사를 마친 후 12주간 운동집단은 유산소성 운동 트레이닝을 받았고 통제집단은 기존 생활을 유지하도록 하였다. 그 후 사후검사 (POST)에서 사전검사와 같은 검사를 실시하였다. 반분법에 의거한 변량분석을 이용하여 결과를 통계적으로 분석하였다. 두 집단간 PRE결과를 보면 연령, 체지방률, 그리고 최대산소섭취량에 유의한 차이가 없는 것으로 나타나 집단 구분이 무선으로 잘 된 것으로 나타났다. 12주간의 트레이닝을 통하여 EX에서 최대산소섭취량이 유의하게 증가한 것으로 나타나 본 연구에서 실시한 유산소성 운동 트레이닝이 심폐지구력 증가에 매우 효과적이었던 것으로 밝혀졌다. 휴식시에는 EX에서 인슐린과 혈당이 트레이닝을 통하여 모두 감소한 것으로 나타나 인슐린 민감성이 증가된 것으로 사료된다. 음식섭취 후에는 EX집단에서 인슐린의 농도가 유의하게 변하지 않는 상태에서 당의 섭취가 유의하게 증가된 것으로 볼 때 역시 인슐린 민감성이 증가된 것으로 보인다. 아울러 운동 후 회복기 중에도 EX에서는 회복기 전반에 걸쳐 인슐린의 농도가 혈당이 모두 감소되는 것으로 나타나 역시 인슐린 민감성이 증가된 것으로 밝혀졌다. 이상의 결과를 종합해 볼 때 12주간의 유산소성 운동 트레이닝은 휴식시 뿐만 아니라 음식섭취 후, 그리고 운동 후 회복기 중에도 인슐린 민감성을 증가시키는 것으로 나타나 건강 개선에 매우 유의한 것으로 밝혀졌다.
Deficit of Somatostatin in the Vitreous Fluid of Patients With Diabetic Macular Edema (2007)

Although diabetic macular edema (DME) is the main cause of visual loss in type 2 diabetic patients (1), its pathogenic mechanisms have been much less studied than proliferative diabetic retinopathy (PDR). The production of both somatostatin (SST) and its receptors by the retina suggests an autocrine action. However, the functional roles of this peptidergic system in retinal physiology are far from being fully elucidated. In recent years we have demonstrated that SST is decreased in the vitreous fluid from patients with PDR, SST-28 being the main molecular variant accounting for this deficit (2,3). Apart from angiostatic properties, SST has anti-inflammatory and anti-edema effects (4–9). Therefore, it is possible that its deficit can be involved not only in PDR but also in DME development.

The aim of the present study was to determine whether, as occurs in PDR, a deficit of intravitreous SST also exists in DME, thus allowing us to identify a new potential pathogenic contributor to this devastating complication of diabetes. Since SST-28 is the main molecular variant in the vitreous fluid, it has been selected as the ideal candidate to be explored.

The study included 35 type 2 diabetic patients (15 with DME and 20 with PDR), in whom a classic three port pars plana vitrectomy was performed. Vitreous from 30 age-matched nondiabetic patients (18 with macular hole and 12 with idiopathic epiretinal membrane) served as the control group. The exclusion criteria were as follows: 1 ) previous vitreoretinal surgery, 2 ) recent vitreous hemorrhage or intravitreous hemoglobin >5 mg/ml, or 3 ) photocoagulation in the preceding 3 months. Fluorescein angiography was performed in all patients with DME in order to assess …
Guided mode resonance in subwavelength metallodielectric free-standing grating for bandpass filtering (2011)

We present the experimental study of a free-standing metallic guided-mode resonant structure, for bandpass filtering applications in the mid-IR wavelength range. Structure consists of a subwavelength gold grating with narrow slits deposited on a silicon nitride membrane. High optical transmission is measured with up to 78% transmission at resonance. Angularly resolved spectra are presented revealing Fano-type resonance.
Abruptly autofocusing waves (2011)

We introduce a new classes of waves that tend to autofocus in an abrupt fashion. These waves can be generated through the use of radially symmetric Airy waves. © 2009 Optical Society of America.
Role of Viatmin E on Indomethacin Induced Low Epididymal Sperm Count in Long Evans Rats (2013)

Bangladesh Journal of Anatomy, January 2012, Vol. 10 No. 1 pp 17-19 DOI: http://dx.doi.org/10.3329/bja.v10i1.15752
Bootstrapper (2012)

In order to enable personalized functionality, such as to log tabletop activity by user, tabletop systems need to recognize users. DiamondTouch does so reliably, but requires users to stay in assigned seats and cannot recognize users across sessions. We propose a different approach based on distinguishing users' shoes. While users are interacting with the table, our system Bootstrapper observes their shoes using one or more depth cameras mounted to the edge of the table. It then identifies users by matching camera images with a database of known shoe images. When multiple users interact, Bootstrapper associates touches with shoes based on hand orientation. The approach can be implemented using consumer depth cameras because (1) shoes offer large distinct features such as color, (2) shoes naturally align themselves with the ground, giving the system a well-defined perspective and thus reduced ambiguity. We report two simple studies in which Bootstrapper recognized participants from a database of 18 users with 95.8% accuracy.
RobCoGen: a code generator for efficient kinematics and dynamics of articulated robots, based on Domain Specific Languages (2016)

This paper presents the Robotics Code Generator (RobCoGen), an open source program that can generate an efficient implementation of rigid body dynamics and kinematics algorithms for articulated robots, such as humanoids and manipulators. New Domain Specific Languages (DSLs) for the specification of robot models and coordinate transforms lie at the core of our software. The technology of DSLs and code generation allows users to deal only with high level information (like a robot model), and relieves them from low level coding of critical routines. The generated code is efficient, tailored to each robot and suitable for applications ranging from simulations to hard real time robot control. This paper describes the rationale and the development of RobCoGen, as well as experiments that include comparisons with other programs: results show a comparable efficiency with code optimized using symbolic simplification (average execution time ratio of 1:22 with SD-FAST) and better performance than a general purpose library (ratio of 3:24 with RBDL). Our design criteria were not limited to efficiency, though, but we considered ease of use and flexibility as equally relevant.
Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x Is Identified as a Minimal Chondroitin Sulfate A-binding Region (2010)

Molecular interactions between the VAR2CSA protein, expressed on the surface of Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are primarily responsible for pregnancy-associated malaria (PAM). Interrupting these interactions may prevent or ameliorate the severity of PAM. Several of the Duffy binding-like (DBL) domains of VAR2CSA, including the DBL3x domain, have been shown to bind CSA in vitro, but a more detailed understanding of how DBL domains bind CSA is needed. In this study, we demonstrate that subdomain 3 (S3), one of the three subdomains of VAR2CSA DBL3x by itself, is the major contributor toward CSA binding. NMR spectroscopy and flow cytometry analyses show that S3 and the intact DBL3x domain bind CSA similarly. Mutations within the S3 portion of DBL3x markedly affect CSA binding. Both recombinant molecules, S3 and DBL3x, are recognized by antibodies in the plasma of previously pregnant women living in malaria-endemic regions of Mali, but much less so by plasma from men of the same regions. As the S3 sequence is highly conserved in all known VAR2CSA proteins expressed by different parasite isolates obtained from various malaria endemic areas of the world, the identification of S3 as an independent CSA-binding region provides a compelling molecular basis for designing interventions against PAM.
Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial (2018)

CHD, coronary heart disease;d, day; erMedDiet, energy-reduced Mediterranean diet (based on the 17-item questionnaire); MedDiet, Mediterranean diet (based on the 14-item questionnaire); 44,45 E, energy intake; LDL, low
Purchasing Patterns of Hog Producers: Implications for Rural Agribusiness (1997)

The consolidation of pork production into fewer and larger operations has implications for rural agribusiness that have traditionally serviced producers. This study examines purchasing patterns of existing pork producers for production inputs by size of operation. Distance traveled to purchase inputs and reasons for bypassing the nearest supplier are evaluated as are the characteristics to be competitive in the pork industry are those most likely to bypass the local supplier.
Dynamics of Uniform Si/SiGe Uniaxial Strain Generation on Compliant Insulating Substrates (2006)

We have developed a model of the time dependence of asymmetric strain generation in Si/SiGe bilayers on compliant substrates, and established a process window for maximum strain asymmetry. The resulting uniaxial silicon strain of 0.75% tension is well-controlled and uniform across the SOI islands
Cryotherapy for the Treatment of Proximal Urethral Condyloma Acuminatum (1987)

Between March and November 1985 we treated 89 female patients with condyloma acuminatum of the lower genital tract. All patients were evaluated with colposcopy, urethroscopy and anoscopy. Carbon dioxide laser vaporization was used to treat condylomata in the cervix, vagina, vulva, anus and distal urethra. Urethral involvement by condylomata was found in 31 patients (35 per cent). Eight patients had biopsy proved proximal urethral condylomata (9 per cent). Cryotherapy was used to treat these lesions. Six patients required only 1 treatment, while 2 required 2 treatments to cure the proximal urethral condylomata.
simultaneous feedback control of bias and modulation currents for injection lasers (1980)

A feedback circuit is described which regulates the light output from an injection laser through simultaneous independent control of bias current and modulation current. The circuit is capable of preserving a large extinction ratio and it is independent of the duty cycle of the modulating signal. Experiments were performed on simulated ‘lasers’ and the results are discussed.
Structural analysis of the temperature-sensitive mutant of bacteriophage T4 lysozyme, glycine 156→aspartic acid. (1987)

The structure of the mutant of bacteriophage T4 lysozyme in which Gly-156 is replaced by aspartic acid is described.The lysozyme was isolated by screening for temperature-sensitive mutants and has a melting temperature at pH 6.5 that is 6.1 "C lower than wild type.The mutant structure is destabilized, in part, because Gly-156 has conformational angles (4, I ) ) that are not optimal for a residue with a &carbon.High resolution crystallographic r5finement of the mutant structure (R = 17.7% at 1.7 A resolution) shows that the Gly -. ) Asp substitution does not significantly alter the configurational angles (4, 9) but forces the backbone to move, as a whole, -0.6A away from its position in wild-type lysozyme.This induced strain weakens a hydrogen bond network that exists in the wild-type structure and also contributes to the reduced stability of the mutant lysozyme.The introduction of an acidic side chain reduces the overall charge on the molecule and thereby tends to increase the stability of the mutant structure relative to wild type.However, at neutral pH this generalized electrostatic stabilization is offset by specific electrostatic repulsion between Asp-156 and Asp-92.The activity of the mutant lysozyme is approximately 50% that of wild-type lysozyme.This reduction in activity might be due to introduction of a negative charge and/or perturbation of the surface of the molecule in the region that is assumed to interact with peptidoglycan substrates.Temperature-sensitive proteins which result from single amino acid substitutions are particularly useful in determining the roles of individual amino acids in the folding and stability of proteins.We report here the three-dimensional structure of a temperature-sensitive lysozyme from bacteriophage T4 in which glycine 156 is replaced by aspartic acid.The mutant protein is one of a series of mutant lysozymes obtained by random and site-directed mutagenesis that is being studied by x-ray crystallography and other techniques (e.g.see Refs.1-8).Bacteriophage T4 lysozyme, an endoacetylmuramidase, is produced late in the infection of Escherichia coli by bacteriophage T4.It cleaves the bacterial cell wall allowing the release