gebhart/patrepeval huggingface dataset:
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break (2008)

The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interaction is specifically required for Tel1 localization to a DNA break and its activation of downstream targets. Computational analysis revealed structural homology between Tel2 and Ddc2 (ATRIP in vertebrates), a partner of Mec1, suggesting a common structural principle used by partners of phoshoinositide 3-kinase-like kinases.
Multi‐layer broadband asymmetric transmission of linearly polarised in active metasurface (2019)

Although many different kinds of polarisers have been extensively studied in the last 20 years, most previous designs were passive and single‐functional designs. In this study, a kind of a new active polarisation converter is designed. The active polarisation converter is comprised of periodically arranged circular ring embedded with PIN diodes. Four different results of polarisation transformation and reflection can be presented by controlling the bias voltage of the PIN diodes. The full‐wave simulation results show that the proposed metasurface can rigorously satisfy the asymmetric transmission and can achieve cross‐polarisation conversion with high efficiencies for linearly polarised waves. In addition, there is another particularly obvious advantage of the proposed structure is its broad operation bandwidth in microwave band, the bandwidth of the polariser reaches 70%, more than 90% cross‐polarisation conversion efficiency is observed from 6.5 to 13.5 GHz.
SeVEP: Secure and Verifiable Electronic Polling System (2019)

Electronic polling systems promise benefits to voters such as accessibility and convenience that enable them to cast their votes at any time, from any Internet-connected computing device anywhere in the world. However, unlike traditional paper-based voting systems, an e-polling system introduces several security risks such as privacy of vote, unlinkability of a voter, voter coercion, secrecy of partial election results, verifiability, and poll integrity. The authenticity of a voter is another security concern, i.e., a voter must be identified through an authentication mechanism that prevents voting of unauthorized voters or multiple voting from authorized voters. Another security concern is the manipulation of votes by an infected (e.g., virus, malware, and so on) voting device. Since the voters use their personal devices to cast votes in an unsupervised environment, a malware-hosted device could make unauthorized modifications to the voter's voting choices. Many e-voting systems have been proposed, however, to date, all these schemes either fail to provide all the required security properties or are not practically feasible on light-weight computing devices. In this paper, we present a secure and verifiable polling system, SeVEP, that employs well-known cryptographic primitives to provide vote and voter's privacy, and poll integrity, confirms the identity of voters through a multifactor authentication scheme, enables multiple voting within the allowed polling period, prevents double voting, and achieves verifiability and uncoercibility in the presence of untrusted voting device. The security, performance, and comparative analysis in terms of security properties and cryptographic costs show that SeVEP is secure, verifiable, and practical e-polling system.
LOCAL ENVIRONMENTAL EFFECTS ON AGN ACTIVITIES (2015)

We performed statistical analysis for a nearby (0.01 < z < 0.05) volume limited (<TEX>$M_r$</TEX> < -19) sample of galaxies via visual inspection and the definition of galaxy pair systems based on the Sloan Digital Sky Survey Data Release 7 in order to confirm the effects of galaxy interaction on AGN activities. We found that local environmental effects such as galaxy interaction have an influence on the enhancement of the frequency and the strength of the AGN activity. This article is the summary of the paper which will be submitted soon.
One-Pot Photo-Induced Sequential CuAAC and Thiol–Ene Click Strategy for Bioactive Macromolecular Synthesis (2014)

Conceptually new one-pot photoinduced sequential click reactions were implemented to yield novel block copolymers with the ability for cell adhesion. Poly(e-caprolcatone) possessing clickable functional groups at the chain ends, namely α-alkynyl-ω-alkenyl-poly(e-caprolactone) (A-PCL-MA), was prepared by ring-opening polymerization of e-caprolactone using propargyl alcohol in the presence of stannous octoate at 110 °C followed by esterification with methacrylic acid. Azide-functional poly(methyl methacrylate) (PMMA-N3) was prepared independently by atom transfer radical polymerization (ATRP) followed by an azidation process using sodium azide. Finally, A-PCL-MA was reacted with PMMA-N3 and N-acetyl-l-cysteine (NAC) in a one-pot process through photoinduced sequential click reactions to furnish desired bioactive block copolymer (PMMA-b-PCL-NAC). A matrix for cell adhesion was then prepared from the yielded block copolymer PMMA-b-PCL-NAC and cell proliferation on the matrix was measured. Cells from the Vero ...
A remote electronic monitoring system for the prevention of pressure sores (2002)

A bed-side system has been developed to non-intrusively monitor the lying position of a patient. It automatically raises an alarm at a nursing station if the patient has not changed his/her position within a specified time. The system has been designed to reduce the incidence of pressure sores in elderly and infirm patients who may be bed-bound and unable to reposition themselves regularly. By continuously monitoring the position of the patient, the time available to nurses is optimised by focusing attention on patients who need it the most. The system can be computerised to facilitate monitoring of nurse response times and efficiency as well as collecting historical data on patients' preferred lying positions.
Anterior portal selection for shoulder arthroscopy (1985)

A posterior portal site has become the accepted standard for introduction of the arthroscope for routine diagnostic procedures of the shoulder. Few published guidelines exist, however, on the optimum and safe positions of accessory portals for introduction of a probe or surgical instruments during shoulder arthroscopy. The relatively thick surrounding muscle layers and the close proximity of vital neurovascular structures would make guidelines for safer and more reproducible accessory portal selection helpful to minimize the risk of injury to these structures. The "intraarticular triangle" bounded by the humeral head, the glenoid rim, and the biceps tendon has been found to be an excellent intraarticular landmark for placement of an accessory anterior portal for shoulder arthroscopy. Anatomical dissections on 20 cadaver shoulders have confirmed that instruments passed through this location are at little risk to injure adjacent neurovascular structures about the shoulder. Clinical data in 30 shoulder arthroscopies performed utilizing this landmark for placement of an anterior portal have confirmed this position to be a safe and useful location for portal placement if proper precautions are followed.
Assessment of Cardiovascular Disease in Rheumatoid Arthritis Patients (2017)

Introduction: The risk of cardiovascular disease is increased in patients with rheumatoid arthritis. Previous studies have compared cardiovascular disease risk factors between patients with and without rheumatoid arthritis, but none have compared rheumatoid arthritis patients with and without cardiovascular disease. To compare rheumatoid arthritis patients with and without cardiovascular disease in addition to cardiovascular disease patients without rheumatoid arthritis.
Methods: Retrospective cross sectional study from 2011-2014 of rheumatology, cardiology, internal medicine, and family medicine clinics at a multi-site academic medical center.
Participants: Rheumatoid arthritis patients had the international classification of disease code “rheumatoid arthritis”. Cardiovascular disease patients had at least one of following codes: peripheral artery disease, coronary artery disease, diabetes, stroke, abdominal aortic aneurysm, transient ischemic attack, or myocardial infarction. All eligible patients were included in the study. Patients were divided into three groups: 2,305 patients with only rheumatoid arthritis, 276 patients with rheumatoid arthritis and cardiovascular disease, and 13,473 patients with only cardiovascular disease. Descriptive statistics was performed.
Results: Only 11,490 (72%) of patients had a full lipid panel available. However, patients with and without a full lipid panel did not differ in age, gender, smoking status, body mass index, or systolic and diastolic blood pressure. Patients with only rheumatoid arthritis had low density lipoprotein levels 19% higher than patients with rheumatoid arthritis and cardiovascular disease (p<0.001, 95% CI: [1.10, 1.28],) and 16% greater than patients with only cardiovascular disease (p<0.001,95% CI: [1.12, 1.20],). Patients with only rheumatoid arthritis also had greater cholesterol and high density lipoprotein levels, but lower triglyceride levels.
Conclusion: Patients with rheumatoid arthritis without known cardiovascular disease do not undergo the same aggressive treatment to improve their lipid profile as patients with cardiovascular disease with or without rheumatoid arthritis. Healthcare profession
A high performance current source inverter (1993)

A modified PWM (pulse width modulated) current source inverter (CSI) that can operate with varying modulation indices (including low modulation indices) is presented. Any standard VSI (voltage source inverter) PWM pattern can be used with this inverter. This feature is obtained without compromising the converter system efficiency and power factor, and at the cost of only one auxiliary switch. The added degree of freedom obtained through modulation index control allows instantaneous control of output current and results in a high-performance inverter system. Inverter steady-state performance equations have been derived, as well as design equations and guidelines. The feasibility and performance of the CSI are verified by simulation and experimental implementation on a 5 kVA system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Four Corners DV-Hop Localization Algorithm for Wireless Sensor Network (2011)

Localization is crucial for wireless sensor networks. In the original DV-Hop algorithm, beacon nodes need to broadcast messages to compute minimum hop-count between each node pair, and beacon nodes also need to broadcast messages to make each unknown node get the average one-hop distance. Twice broadcasts cause a lot of communication. The communication causes a lot of energy consumption. In order to address this problem, an improved algorithm, named Four Corners DV-Hop algorithm, is proposed. The Four Corners DV-Hop algorithm utilizes the beacon placement to divide the whole area into some small regions. We analyze the communication model and set a threshold to make a message just broadcasted in a small region instead of in the whole area to reduce communication. Compared to the original DV-Hop algorithm, the Four Corners DV-Hop localization algorithm reduces a lot of communication and is more accurate through the simulation results.
Dry thermal oxidation of a graded SiGe layer (2001)

A method for the dry thermal oxidation of a strained SiGe layer is proposed. By oxidation of a graded Si1−xGex layer, the effect of Ge pileup was significantly reduced and the undesirable strain relaxation by defect formation is prohibited. After oxidation, the oxidized SiGe layer was homogenized by postannealing process, and thereby a SiO2/SiGe interface with good structural properties was obtained. During postannealing, the homogenization was significantly enhanced by strain-induced diffusion, and it was clearly proved by the uphill diffusion. This result can propose an alternative oxidation method of strained SiGe/Si heterostructures.
The opium poppy genome and morphinan production (2018)

Morphinan-based painkillers are derived from opium poppy (<i>Papaver somniferum</i> L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the <i>STORR</i> gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
Studies on the Interfacial Characteristics of Fluorite in Aqueous Solution and on the Flotation (1978)

The studies concerning fluorite were carried out following the previous paper (3).When the pH of solution was varied, the isoelectric point of fluorite was pH 6.65 (Fig. 3).When an equivalence point (EP) is defined as the pH at which any selected pair of positive and negative ions have equivalent concentrations, EP (CaOH+, HF2-) was pH 6.7 (Fig. 4). There was a good agreement between the isoelectric point and the EP (CaOH+, HF2-).And also, the other results showed around the same pH or pH region, that is, the pH value at the zero H+and OH-demand was about pH 6.4 (Fig. 1), in any initial pH of fluorite suspensions after enough time pH would be converging on an equilibrium pH value between pH 6 and 7 (Fig. 2). At pH 10, the isoelectric point was about pCa2.7 (Fig.5).In alkaline region, it was observed that F-on the surface was exchanged by OH- (Fig.7).In determining the potential of fluorite in an aqueous solution, ionic species playing an important role are H+andOHand also Ca++and F. CaOH+and HF2-could be considered as the ionic species, too.About adsorption of SDS on fluorite, both chemical adsorption forming surface Cadodecylsulfate (Fig.13) and electrostatic adsorption should be considered.On the other hand, adsorption of DAA is mainly electrostatic.
Murine glia express the immunosuppressive cytokine, interleukin‐10, following exposure to Borrelia burgdorferi or Neisseria meningitidis (2006)

There is growing appreciation that resident glial cells can initiate and/or regulate inflammation following trauma or infection in the central nervous system (CNS). We have previously demonstrated the ability of microglia and astrocytes, resident glial cells of the CNS, to respond to bacterial pathogens by rapid production of inflammatory mediators. However, inflammation within the brain parenchyma is notably absent during some chronic bacterial infections in humans and nonhuman primates. In the present study, we demonstrate the ability of the immunosuppressive cytokine, interleukin-10 (IL-10), to inhibit inflammatory immune responses of primary microglia and astrocytes to B. burgdorferi and N. meningitidis, two disparate gram negative bacterial species that can cross the blood-brain barrier in humans. Importantly, we demonstrate that these organisms induce the delayed production of significant quantities of IL-10 by both microglia and astrocytes. Furthermore, we demonstrate that such production occurs independent of the actions of bacterial lipopolysaccharide and is secondary to the autocrine or paracrine actions of other glia-derived soluble mediators. The late onset of IL-10 production by resident glia following activation, the previously documented expression of specific receptors for this cytokine on microglia and astrocytes, and the ability of IL-10 to inhibit bacterially induced immune responses by these cells, suggest a mechanism by which resident glial cells can limit potentially damaging inflammation within the CNS in response to invading pathogens, and could explain the suppression of inflammation seen within the brain parenchyma during chronic bacterial infections.
Body PiN diode inactivation with low on-resistance achieved by a 1.2 kV-class 4H-SiC SWITCH-MOS (2017)

Integration of SBD into SiC-MOSFET is promising to solve body-PiN-diode related problems known such as forward degradation and reverse recovery loss. Particularly in lower breakdown-voltage-class SBD-integrated MOSFET, cell pitch reduction has a greater impact on inactivating the body-PiN-diode. Here, we developed a novel device called an SBD-wall-integrated trench MOSFET (SWITCH-MOS), in which small cell pitch of 5p.m was realized by utilizing trench side walls both for SBD and MOS channel with buried p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> layer. The fabricated 1.2 kV SWITCH-MOS successfully suppressed the forward degradation under extremely high current density condition with low switching loss, low specific on-resistance, and low leakage current.
Reactive Nitrile Groups. II. The Reaction of Cyanoesters with Aqueous Amines1 (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactive Nitrile Groups. II. The Reaction of Cyanoesters with Aqueous Amines1Marvin J. Hurwitz, Lawrence J. Exner, and Peter L. de BennevilleCite this: J. Am. Chem. Soc. 1955, 77, 12, 3251–3253Publication Date (Print):June 1, 1955Publication History Published online1 May 2002Published inissue 1 June 1955https://pubs.acs.org/doi/10.1021/ja01617a030https://doi.org/10.1021/ja01617a030research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A pH sensitive fluorescent cyanine dye for biological applications (2000)

A pentamethine cyanine dye has been synthesised that is fluorescent when protonated, becoming non-fluorescent upon proton abstraction. The probe has a pKa of 7.5, with observable changes in the fluorescent emission properties across a pH range of 6.0–8.0, therefore providing a useful probe for studying pH in biological media.
ZUSAMMENFASSENDE SCHLUSSFOLGERUNGEN UND AUSBLICK (2008)

Im abschlie&#223;enden Kapitel werden die Ergebnisse der Arbeit zusammengefasst und Ans&#228;tze f&#252;r den weiteren Forschungsbedarf abgeleitet. Anschlie&#223;end werden die Implikationen f&#252;r die Unternehmenspraxis dargestellt.
Transition‐Metal‐Catalyzed Alkyl–Alkyl Cross‐Coupling Reactions (2023)

The cross‐coupling reaction of alkyl halides with alkyl metal reagents is a straightforward synthetic method to construct saturated carbon frameworks. Although the development of alkyl–alkyl cross‐coupling reactions has lagged behind advances made in the cross‐coupling of unsaturated compounds, various catalysts for alkyl–alkyl coupling are now available. The construction of challenging saturated carbon frameworks, such as those incorporating a quaternary carbon or chiral carbon center(s), is accomplished with the appropriate combination of catalyst and coupling partners. This chapter outlines the current understanding and efficient application of alkyl–alkyl cross‐coupling reactions. The mechanism of the process is presented for representative catalysts and the scope and limitations of the coupling reaction are discussed for each catalytic system. Successful applications of alkyl–alkyl cross‐coupling processes are also described for the stereoselective formation of saturated hydrocarbon frameworks and the synthesis of natural products.
Decreased expression of CD7 occurs in rheumatoid arthritis. (1988)

To evaluate the possibility of antigenic modulation in vivo, we studied the expression of the CD7 antigen on the surface of peripheral blood and intrasynovial lymphocytes from patients with rheumatoid arthritis (RA). This disease is noted for features predicting changes in CD7: (1) increased expression related to activation during an immune response through possible contact with 'disease associated antigens' and (2) decreased expression associated with lymphocytes moving through tissue. We found a highly significant decrease of CD7 on RA T cells in vivo (P less than 10(-4] that was not related to disease activity, drug ingestion, or abnormalities in the ability of RA T cells to express or modulate the antigen in vitro. Similar decreased expression was observed on many intrasynovial T cells that were nevertheless activated as measured by expression of activation markers such as Act I (a late lymphocyte activation antigen) and Act II (the transferrin receptor). Decreased expression of CD7 occurs naturally in vivo in RA; this observation may have future significance in better understanding the immunopathogenesis of this disease.
Synthesis, Thermal Stability, Biophysical Properties, and Molecular Modeling of Oligonucleotides of RNA Containing 2′-O-2-Thiophenylmethyl Groups (2016)

Dodecamers of RNA [CUACGGAAUCAU] were functionalized with C2'-O-2-thiophenylmethyl groups to obtain oligonucleotides 10-14 and 17. The modified nucleotides were incorporated into RNA strands via solid-phase synthesis. The biophysical properties of these ONs were used to quantify the effects of this modification on RNA:RNA and RNA:DNA duplexes. A combination of UV-vis and circular dichroism were used to determine thermal stabilities of all strands, which hybridized into A-form geometries. Destabilization of the double stranded RNA was measured as a function of number of consecutive modifications, reflected in decreased thermal denaturation values (ΔT<sub>m</sub>, ca. 2.5-11.5 °C). Van't Hoff plots on a duplex containing one modification (10:15) displayed a ca. ΔΔG° of +4 kcal/mol with respect to its canonical analogue. Interestingly, hybridization of two modified strands (13:17, containing a total of eight modifications) resulted in increased stability and a distinct secondary structure, reflected in its CD spectrum. Molecular modeling based on DFT calculations shed light on the nature of this stability, with induced changes in the torsional angle δ (C5'-C4'-C3'-O3) and phosphate-phosphate distances that are in agreement with a compacted structure. The described synthetic methodology and structural information will be useful in the design of thermodynamically stable structures containing chemically reactive modifications.
Asymmetric Dimethylarginine Responses During Interferon-α–Induced Depression in Patients With Chronic Hepatitis C Infection (2014)

Depression in response to IFN-α treatment is associated with elevated ADMA levels. These findings are relevant to nitric oxide-related biological pathways linking depression to increased cardiovascular disease risk. Future studies are needed to clarify the role of serotonin in these pathways and may lead to preventative treatment strategies.