gebhart/patrepeval huggingface dataset:
Closure of bronchopleural fistula after pneumonectomy with a pedicled intercostal muscle flap (1999)

Objectives: The value of the pedicled intercostal muscle ap for the closure of postpneumonectomy bronchopleural stulas was studied retrospectively. Methods: Bronchopleural stula was suspected in case of fever, cough, putrid or haemorrhagic expectoration, in combination with a rise of WBC and CRP. Fistula diagnosis was established bronchoscopically. Two patients underwent an initial trial of bronchoscopic sealing, the rest were reoperated immediately after stula diagnosis. Immediately after operation antibiotic irrigation according to culture sensitivity was started via a single chest tube drainage twice a day. After instillation of antibiotics the drain was kept clamped for 3 h. Culture samples were obtained twice a week. Empyema was considered eradicated, if three subsequent cultures showed no bacterial growth. After drain removal the patients were kept in hospital for another week and observed for clinical signs of infection, WBC and CRP were controlled. Age, side, sex, histology, TNM-stage, duration of hospital stay after stula diagnosis (days), duration of treatment (dened as the duration of chest tube drainage in days after operation), total hospital stay (including the initial hospital stay for primary resection and the hospital stay for stula treatment in case of readmission), stula size (mm), interval (days) between primary operation and stula formation, and bacteriology were recorded. Results: Eight patients (seven male) were treated. Age ranged from 46 to 70 years (mean 57.86). Six stulas were located on the right side. All patients had non small cell lung cancer. Interval ranged from 2 to 72 days (mean 26.9 days). Fistula size ranged from 1 to 7 mm (mean 3.43). Seven stulas were successfully closed. Duration of treatment lasted from 15 to 28 days in those patients treated successfully (mean 17). Hospital stay ranged from 15 to 31 days (mean 24.4). In one patient the ap became necrotic, he was successfully treated with total thoracoplasty. One patient died on the 38th day after rethoracotomy due to aspiration pneumonia. At postmortem examination the bronchial stump was closed. Conclusion: The use of the pedicled intercostal muscular ap is an efcient method for the closure of bronchopleural stula after pneumonectomy.
Identification of a gp100 epitope recognized by HLA-A3 restricted melanoma infiltrating lymphocytes (1997)

The large majority of known melanoma-associated antigenic peptides presented by MHC class I molecules are presented by the most frequent allele, HLA-A*0201. Thus although a significant percentage of Caucasians express HLA-A3, no melanoma-associated antigenic peptide presented by this allele has yet been identified. We show here that the T cell clone M45-10 isolated from tumor infiltrating lymphocytes recovered from a melanoma biopsy recognizes the gp100-derived peptide ALLAVGATK presented by HLA-A*0301. Since gp100 is expressed on most melanoma cells, our results imply that the gp100-based anti-melanoma strategies developed for individuals expressing HLA-A2 will also be applicable to those expressing HLA-AS (about one Caucasian in four). gp100 is therefore a particularly promising melanoma antigen, as different peptides derived from it can be presented by at least two different frequently encountered HLA class I molecules.
Myc suppression of Nfkb2 accelerates lymphomagenesis (2010)

Nfkb2 is suppressed by c-Myc and harnesses Myc-driven lymphomagenesis. These data thus link Myc-driven lymphomagenesis to the non-canonical NF-kappaB pathway.
Korean speakers hyperarticulate vowels in polite speech* (2021)

In line with recent attention to the multimodal expression of politeness, the present study examined the association between polite speech and acoustic features through the analysis of vowels produced in casual and polite speech contexts in Korean. Fourteen adult native speakers of Seoul Korean produced the utterances in two social conditions to elicit polite (professor) and casual (friend) speech. Vowel duration and the first (F1) and second formants (F2) of seven sentence- and phrase-initial monophthongs were measured. The results showed that polite speech shares acoustic similarities with vowel production in clear speech: speakers showed greater vowel space expansion in polite than casual speech in an effort to enhance perceptual intelligibility. Especially, female speakers hyperarticulated (front) vowels for polite speech, independent of speech rate. The implications for the acoustic encoding of social stance in polite speech are further discussed.
The composition of corn oil obtained by the alcohol extraction of ground corn (2005)

Abstract All commercial corn oil is obtained by the hexane extraction of corn germ. The chemical composition of commercial corn oil has been well characterized. This study was under‐taken to quantitatively evaluate the lipid composition of corn oil obtained by the ethanol extraction of ground, whole corn kernels. When corn oil was obtained by extracting ground corn kernels (ground corn) with polar or nonpolar solvents, the resulting corn oil contained much higher levels of hydroxycinnamate steryl esters (≈0.3%) than those found in commercial hexane‐extracted corn (germ) oil (≈0.02%). The levels of valuable tocopherols and tocotrienols were also significantly higher in kernel oil than in traditional corn germ oil. We previously reported that when corn oil was obtained by extracting corn kernels with polar solvents, the oil contained two polyamine conjugates, diferuloylputrescine and p ‐coumaroyl feruloylputrescine. In the current study, when ground corn was extracted with ethanol, the resulting corn oil contained about 0.5% diferuloylputrescine and about 0.2% p ‐coumaroyl feruloylputrescine. This is the first study to quantify these unique compounds in corn oil extracted by new techniques. This compositional information is important because this new oil is being considered for human food use.
Latzko operation for vault vesicovaginal fistula (2006)

The Latzko procedure is an efficient, safe, and simple technique for the management of vault vesicovaginal fistulas, and can therefore be proposed as the first-line surgical treatment.
Microwave-assisted conversion of oximes into nitriles in the presence of a zeolite (2002)

Aromatic aldoximes were converted to the corresponding nitriles in a microwave oven in the presence of a molecular sieve-type modified zeolite, Ersorb, under solvent-free conditions. The yields depended on the substituent of the oxime.
Evidence for stroke-induced neurogenesis in the human brain (2006)

Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.
The physiological role of endoglin in the cardiovascular system (2010)

Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for members of the transforming growth factor-β superfamily of proteins. A major role for endoglin in regulating transforming growth factor-β-dependent vascular remodeling and angiogenesis has been postulated based on the following: 1) endoglin is the gene mutated in hereditary hemorrhagic telangiectasia type 1, a disease characterized by vascular malformations; 2) endoglin knockout mice die at midgestation because of defective angiogenesis; 3) endoglin is overexpressed in neoangiogenic vessels, during inflammation, and in solid tumors; and 4) endoglin regulates the expression and activity of endothelial nitric oxide synthase, which is involved in angiogenesis and vascular tone. Besides the predominant form of the endoglin receptor (long endoglin isoform), two additional forms of endoglin have been recently reported to play a role in the vascular pathology and homeostasis: the alternatively spliced short endoglin isoform and a soluble endoglin form that is proteolytically cleaved from membrane-bound endoglin. The purpose of this review is to underline the role that the different forms of endoglin play in regulating angiogenesis, vascular remodeling, and vascular tone, as well as to analyze the molecular and cellular mechanisms supporting these effects.
Bis[14β-hydroxy-3β-O-(L-thevetosyl)-5β-card-20(22)-enolide] methanol solvate monohydrate and 3β-O-(L-2′-o-acetylthevetosyl)-14β-hydroxy-5β-card-20(22)-enolide (2003)

The title compounds, 2C(30)H(46)O(8).CH(3)OH.H(2)O, (I), and C(32)H(48)O(9), (II), respectively, are cardenolide glycosides which were isolated from the seeds of Cerbera odollam. There are two crystallographically independent cardenolide molecules in (I), together with one methanol and one water solvate molecule. In both (I) and (II), the steroid nuclei are in cis/trans/cis configurations, with the cyclopentane rings showing conformational flexibility, viz. an envelope conformation in (I) and a twisted conformation in (II). In both compounds, the lactone ring is nearly orthogonal to the cyclopentane ring. The packing of (I) is composed of molecular layers stabilized by five O-H...O hydrogen bonds. In the packing of (II), the molecules are packed into columns by one O-H...O hydrogen bond, and are further interconnected into a three-dimensional network by one O-H...O and three C-H...O interactions.
Increased Expression of NPM1 Suppresses p27Kip1 Function in Cancer Cells (2020)

p27<sup>Kip1</sup>, a major cyclin-dependent kinase inhibitor, is frequently expressed at low levels in cancers, which correlates with their malignancy. However, in this study, we found a qualitative suppression of p27 overexpressed in some cancer cells. By proteomic screening for factors interacting with p27, we identified nucleophosmin isoform 1 (NPM1) as a novel p27-interacting factor and observed that NPM1 protein was expressed at high levels in some cancer cells. NPM1 overexpression in normal cells suppressed p27 function, and conversely, NPM1 knockdown in cancer cells restored the function in vitro. Furthermore, the tumors derived from cancer cells carrying the combination of p27 overexpression and NPM1 knockdown constructs showed significant suppression of growth as compared with those carrying other combinations in mouse xenograft models. These results strongly suggest that increased expression of NPM1 qualitatively suppresses p27 function in cancer cells.
Study on voltage regulation method in the power distribution system (2007)

This paper focuses on distribution voltage control when over-voltage or under-voltage occurs in the low-voltage (LV) distribution line. The distribution voltage control is performed by transformer and ac-ac converter. Transformer supports a part of settled voltage and ac-ac converter controls voltage disturbance. Bi-directional ac-ac converter employs digital control using field programmable gate array (FPGA). This method enables simple and fast the distribution voltage control. In this paper, voltage control concept is explained. Scaled-down experimental result is shown, when load condition is changed.
Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis (2016)

Machine learning combining clinical and CCTA data was found to predict 5-year ACM significantly better than existing clinical or CCTA metrics alone.
A Three-Factor-Based Authentication Scheme of 5G Wireless Sensor Networks for IoT System (2023)

Internet of Things (IoT) is an expanding technology that facilitate physical devices to inter-connect each other over a public channel. Moreover, the security of the next-generation wireless mobile communication technology, namely 5G with IoT, has been a field of much interest among researchers in the last several years. Previously, Sharif et al. had suggested an IoTbased lightweight three-party authentication scheme proclaiming a secured scheme against different threats. However, it was found that the scheme could not achieve user anonymity and guarantee session key security. Additionally, the scheme fails to provide proper authentication in the login phase, and it s unable to update a new password in the password change phase. Thus, we propose an improved three-factor-based data transmission authentication scheme (TDTAS) to address the weaknesses. The formal security analysis has been proved using the Real-or-Random (RoR) model. The informal security analysis demonstrates that the scheme is secure against several known attacks and achieves more security features. In addition, the comparison of the work with other related schemes demonstrates the proposed scheme has less communicational and storage costs.
Electron multibeam technology for mask and wafer writing at 0.1 nm address grid (2013)

IMS Nanofabrication realized a 50 keV electron multibeam proof-of-concept (POC) tool confirming writing principles with 0.1 nm address grid and lithography performance capability. The POC system achieves the predicted 5 nm 1 sigma blur across the 82 μm×82 μm array of 512×512 (262,144) programmable 20 nm beams. 24-nm half pitch (HP) has been demonstrated and complex patterns have been written in scanning stripe exposure mode. The first production worthy system for the 11-nm HP mask node is scheduled for 2014 (Alpha), 2015 (Beta), and first-generation high-volume manufacturing multibeam mask writer (MBMW) tools in 2016. In these MBMW systems the max beam current through the column is 1 μA. The new architecture has also the potential for 1× mask (master template) writing. Substantial further developments are needed for maskless e-beam direct write (EBDW) applications as a beam current of >2 mA is needed to achieve 100 wafer per hour industrial targets for 300 mm wafer size. Necessary productivity enhancements of more than three orders of magnitude are only possible by shrinking the multibeam optics such that 50 to 100 subcolumns can be placed on the area of a 300 mm wafer and by clustering 10 to 20 multicolumn tools. An overview of current EBDW efforts is provided.
New Aequorea fluorescent proteins for cell-free bioengineering (2022)

Abstract Recently, a new subset of fluorescent proteins has been identified from the Aequorea species of jellyfish. These fluorescent proteins were characterized in vivo ; however, there has not been validation of these proteins within cell-free systems. Cell-free systems and technology development is a rapidly expanding field, encompassing foundational research, synthetic cells, bioengineering, biomanufacturing and drug development. Cell-free systems rely heavily on fluorescent proteins as reporters. Here we characterize and validate this new set of Aequorea proteins for use in a variety of cell-free and synthetic cell expression platforms. Abstract Figure
Development of Nano-sized Protein Arrays using Block Copolymer Self-Assemblies (2004)

The single molecule approach is potentially of great technological interest as a complementary means to obtain information about protein conformation or molecular interaction. The measurement for molecular interaction in single molecule level requires that the molecule in the question is immobilized by binding to an appropriate surface. W have developed a novel fabrication method of nanopatterned array of bio-molecules with ultra-high density, using self-assembly of block-copolymers. Compared to previous lithographic methods, selfassembly of block-copolymers makes it easier to fabrication of patterns with ~ 10 nanometer feature size and to reduce the number of processing steps. In this work, we have detected a single molecule array on the basis of immunoreaction using protein conjugated gold nanoparticle. In this manner, BCP structure played an important role as confining molecules in single molecule level to a hole avoiding intermolecular interaction or nonspecific binding.
Feature Extraction for Emotion Recognition and Modelling Using Neurophysiological Data (2016)

The ubiquitous computing paradigm is becoming a reality; we are reaching a level of automation and computing in which people and devices interact seamlessly. However, one of the main challenges is the difficulty users have in interacting with these increasingly complex systems. Ultimately, endowing machines with the ability to perceive users' emotions will enable a more intuitive and reliable interaction. Consequently, using the electroencephalogram (EEG) as a bio-signal sensor, the affective state of a user can be modelled and subsequently utilised in order to achieve a system that can recognise and react to the users emotions. In this context, this paper investigates feature vector generation from EEG signals for the purpose of affective state modelling based on Russells Circumplex Model. Investigations are presented that aim to provide the foundation for future work in modelling user affect and interaction experiences through exploitation of different input modalities. The DEAP dataset was used within this work, along with a Support Vector Machine, which yielded reasonable classification accuracies for Valence and Arousal using feature vectors based on statistical measurements, band power from the , β, δ and θ waves, and High Order Crossing of the EEG signal.
Transplanted cryopreserved encapsulated porcine hepatocytes are as effective as fresh hepatocytes in preventing death from acute liver failure in rats. (2000)

The implantable BAL using xenogeneic porcine hepatocytes was able in preventing death from acute liver failure without immunosuppressive therapy. Encapsulated cryopreserved hepatocytes were as effective as fresh hepatocytes.
Microservices Security Fundamentals (2018)

The microservices architecture expands the attack surface with multiple microservices communicating with each other remotely. Instead of having one or two entry points, now we have hundreds of entry points to worry about. It’s a common principle in security that the strength of a given system is only as strong as the strength of its weakest link. The more entry points we have, the broader the attack surface, and the higher the risk of being attacked. Unlike in a monolithic application, the depth and breadth we need to worry about in securing a microservice is much higher. There are multiple perspectives in securing microservices: secure development lifecycle and test automation, security in DevOps, and application level security.
Modification of Drinking (1973)

Modification of Drinking Get access M. EVANS, F.R.C.P., F.R.C.PSYCH., D.P.M. M. EVANS, F.R.C.P., F.R.C.PSYCH., D.P.M. *Whitchurch HospitalCardiff Search for other works by this author on: Oxford Academic PubMed Google Scholar Alcohol and Alcoholism, Volume 8, Issue 3, Summer 1973, Pages 111–113, https://doi.org/10.1093/oxfordjournals.alcalc.a046111 Published: 01 July 1973
High-temperature self-circulating thermoacoustic heat exchanger (2005)

Thermoacoustic and Stirling engines and refrigerators use heat exchangers to transfer heat between the oscillating flow of their thermodynamic working fluids and external heat sources and sinks. An acoustically driven heat-exchange loop uses an engine’s own pressure oscillations to steadily circulate its own thermodynamic working fluid through a physically remote high-temperature heat source without using moving parts, allowing for a significant reduction in the cost and complexity of thermoacoustic and Stirling heat exchangers. The simplicity and flexibility of such heat-exchanger loops will allow thermoacoustic and Stirling machines to access diverse heat sources and sinks. Measurements of the temperatures at the interface between such a heat-exchange loop and the hot end of a thermoacoustic-Stirling engine are presented. When the steady flow is too small to flush out the mixing chamber in one acoustic cycle, the heat transfer to the regenerator is excellent, with important implications for practical use.
Novel structure of organic electroluminescence cells with conjugated oligomers (1993)

Organic electroluminescence (EL) cells with a novel structure, ITO/semiconducting oligothiophene layer/oligophenylene layer/emitting layer/Mg:Ag, were studied. The oligothiophene layer enhanced hole injection and hole transport into the emitting layer (EML), while the oligophenylene layer achieved electron confinement in EML by electron blocking. In addition, we found that the oligophenylene layer inhibited energy transfer from EML to the oligothiophene layer and played an important role in increasing the luminous efficiency. For our fabricated EL cell with tris(8-hydroxyquinoline)aluminum as an emitting molecule, we succeeded in obtaining bright emission over 2000 cd/m2 at a voltage of about 10 V.
Microservices-based software architecture and approaches (2017)

In the last few years, a revised software architecture style has been developed to design new software applications. This architecture style is particularly suited for use cases in the aerospace industry, from an independently deployable software service. The microservices architectural style develops a single application as a suite of small services, each running in its own process and communicating with lightweight mechanisms. These services are built around business and mission capabilities and independently deployable by fully automated machinery. With microservices, some types of applications become easier to build and maintain when they are broken down into smaller, composable pieces that work together. Each component is then developed separately, and the application is then simply the sum of its constituent components. This is in contrast to a traditional, “monolithic” application which is all developed in one piece. This paper will discuss, several aspects of microservices-based architecture, including several potential use cases for the aerospace industry. The characteristics of microservice-based architecture such as componentization, organization, endpoints and messaging mechanisms. The technical implementation of microservices by reviewing containerization, services communication and related architectural components. Specific open source projects and components that can be utilized to build microservices-based architecture. A sample set of use cases.
Cancer Risk in the Heart Failure Population: Epidemiology, Mechanisms, and Clinical Implications (2020)

Not only cancer and HF share similar risk factors but also HF itself can stimulate cancer development. Some cytokines produced by the failing heart induce mild inflammation promoting carcinogenesis, as it has been recently suggested by an experimental model of HF in mice. The incidence of new-onset cancer is higher in HF patients compared to the general population, and it significantly worsens their prognosis. Moreover, the management of HF patients developing new-onset cancer is challenging, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs.