gebhart/patrepeval huggingface dataset:
Applications of isotropic shifts to the investigation of structures and structural equilibriums of metal complexes (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplications of isotropic shifts to the investigation of structures and structural equilibriums of metal complexesRichard H. HolmCite this: Acc. Chem. Res. 1969, 2, 10, 307–316Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://doi.org/10.1021/ar50022a004Request reuse permissionsArticle Views200Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
The relative significance of colposcopic descriptive appearances in the diagnosis of cervical intraepithelial neoplasia (1990)

Four hundred and seventy seven colposcopic appearances have been analysed in 252 patients to determine their histopathological correlation and clinical efficiency in the diagnosis of cervical intraepithelial neoplasia (CIN). Immature metaplasia, cervical ectopy and cervicitis produced a considerable quotient of abnormal colposcopic appearances. Acetowhite epithelium had the highest sensitivity (92%), lowest specificity (25%) and a positive predictive value of 61%. Mosaicism and punctation were less sensitive (30 and 38%), but more specific (89 and 85%), respectively and had superior positive predictive values.
Longterm Outcomes of Living Donor Liver Transplantation for Glycogen Storage Disease Type 1b (2019)

Glycogen storage disease (GSD) type 1b (Online Mendelian Inheritance in Man [OMIM] 232220) is an autosomal recessive inborn error of carbohydrate metabolism caused by defects in glucose-6-phosphate translocase. GSD1b patients have severe hypoglycemia with several clinical manifestations of hepatomegaly, obesity, a doll-like face, and neutropenia. Liver transplantation (LT) has been indicated for severe glucose intolerance, poor metabolic control (PMC), and poor growth (PG). We retrospectively reviewed 11 children with GSD1b who underwent living donor liver transplantation (LDLT) at the National Center for Child Health and Development in Tokyo, Japan. Between November 2005 and December 2018, 495 children underwent LDLT with an overall 10-year patient and graft survival of 90.6% and 88.9%, respectively. Of these, LT was indicated for 11 patients with GSD1b. All patients are doing well with the stabilization of glucose intolerance and decreased hospitalization for infectious complications. Demand for granulocyte colony-stimulating factor significantly decreased. However, although LT stabilized the blood glucose level, the platelet function was not improved. The posttransplant developmental quotient (DQ) remained similar to the pretransplant DQ without deterioration. LDLT is a feasible procedure for GSD1b patients with regard to the longterm prognosis. LT should be considered for patients with severe glucose intolerance to protect the cognitive function against hypoglycemic encephalopathy and to ameliorate PMC and PG.
Data from Clinical and Molecular Characteristics of <i>NF1</i>-Mutant Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt;&lt;i&gt;NF1&lt;/i&gt; is a tumor suppressor that negatively regulates Ras signaling. &lt;i&gt;NF1&lt;/i&gt; mutations occur in lung cancer, but their clinical significance is unknown. We evaluated clinical and molecular characteristics of &lt;i&gt;NF1&lt;/i&gt; mutant lung cancers with comparison to tumors with &lt;i&gt;KRAS&lt;/i&gt; mutations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Between July 2013 and October 2014, 591 non–small cell lung cancer (NSCLC) tumors underwent targeted next-generation sequencing in a 275 gene panel that evaluates gene mutations and genomic rearrangements. &lt;i&gt;NF1&lt;/i&gt; and &lt;i&gt;KRAS&lt;/i&gt; cohorts were identified, with subsequent clinical and genomic analysis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Among 591 patients, 60 had &lt;i&gt;NF1&lt;/i&gt; mutations (10%) and 141 (24%) had &lt;i&gt;KRAS&lt;/i&gt; mutations. 15 &lt;i&gt;NF1&lt;/i&gt; mutations (25%) occurred with other oncogenic mutations [BRAF (2); ERBB2 (2); KRAS (9); HRAS (1); NRAS (1)]. There were 72 unique &lt;i&gt;NF1&lt;/i&gt; variants. &lt;i&gt;NF1&lt;/i&gt; tumor pathology was diverse, including both adenocarcinoma (36, 60%) and squamous cell carcinoma (10, 17%). In contrast, &lt;i&gt;KRAS&lt;/i&gt; mutations occurred predominantly in adenocarcinoma (136, 96%). Both mutations were common in former/current smokers. Among &lt;i&gt;NF1&lt;/i&gt; tumors without concurrent oncogenic alterations, &lt;i&gt;TP53&lt;/i&gt; mutations/2-copy deletions occurred more often (33, 65%) than with &lt;i&gt;KRAS&lt;/i&gt; mutation (46, 35%; &lt;i&gt;P&lt;/i&gt; &lt; 0.001). No difference between cohorts was seen with other tumor suppressors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt;&lt;i&gt;NF1&lt;/i&gt; mutations define a unique population of NSCLC. &lt;i&gt;NF1&lt;/i&gt; and &lt;i&gt;KRAS&lt;/i&gt; mutations present in similar patient populations, but &lt;i&gt;NF1&lt;/i&gt; mutations occur more often with other oncogenic alterations and &lt;i&gt;TP53&lt;/i&gt; mutations. Therapeutic strategies targeting &lt;i&gt;KRAS&lt;/i&gt; activation, including inhibitors of MAP kinase signaling, may warrant investigation in &lt;i&gt;NF1&lt;/i&gt; mutant tumors. Tumor-suppressor inactivation patterns may help further define novel treatment strategies. &lt;i&gt;Clin Cancer Res; 22(13); 3148–56. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
The Hygiene Hypothesis: Do We Still Believe in It? (2009)

Numerous epidemiological studies suggest that there is an inverse relationship between allergic diseases and infections in early childhood, but there are also several well-conducted epidemiological studies that seemingly contradict this relationship. The maturation of the immature immune regulation after birth is largely driven by exposure to microbes. Germ-free animals manifest excessive immune responses when immunized and they do not develop normal immune regulation. The controversy regarding the role of infections for subsequently developing allergy is partly due to varying clinical definitions of 'allergy'. Thus, wheezing and asthma have often been included as outcomes. The hypothesis that commensal microbes are the normal stimulants for the maturation towards a balanced immune response is relevant for IgE-mediated disease manifestations, rather than recurrent bronchial obstruction per se. Epidemiological, clinical and animal studies taken together suggest that broad exposure to a wealth of commensal, non-pathogenic microorganisms early in life are associated with protection, not only against IgE-mediated allergies, but also conceivably against type-1 diabetes and inflammatory bowel disease. This has little relationship with 'hygiene' in the usual meaning of the word. The term 'hygiene hypothesis' is unfortunate, as it is misleading. A better term would be 'microbial deprivation hypothesis'.
Development of Micro Traction Drive Modified From Angular Ball Bearing (2004)

Micro traction drive is a device to transmit driving force modified from angular ball bearing. The traction force is applied with the pre-load between inner lace and outer lace as thrust force. The driving force is transmitted by the contact of the retainer with the rolling element in rotating direction. Experiment for micro traction drive using angular ball bearing of 10 mm in inner diameter, 30 mm in outer diameter and 9 mm in width was carried out, and was compared to that for equivalent planetary gear head. Featuring small size high torque, high number of revolution, low noise & low vibration, micro traction drive is expected as the alternative transmission of small size planetary gear.
IMMUNOMODULATION WITH CTLA4-Ig IN ISLET TRANSPLANTATION (2002)

The need for permanent, nonspecific, and potentially harmful immunosuppression remains a major obstacle for islet transplantation. The response of a type 1 diabetic recipient to an islet graft includes a specific allogenic immune response and the recurrence of autoimmunity. Free or encapsulated in an immunoisolation device, islet cells are exposed to immune aggression, initiated by donor antigen-presenting cells or by indirect, host antigen-presenting cell-mediated antigen presentation. CTLA4-Ig is a genetically engineered fusion protein of human CTLA4 and the IgG 1 Fc region. It prevents T-cell activation by binding to human B7, which costimulates T cells through CD28. Interesting data were reported in experimental islet transplantation, suggesting that CTLA4-Ig may be slightly but significantly beneficial to islet allograft survival, although studies in autoimmune diabetes are scarce. The main limitations include transient and low levels of expression when CTLA4-Ig is delivered locally, a predominant effect on the direct recognition pathway, and the lack of effect on memory cells. Clinical trials in islet transplantation could be discussed in nonuremic patients, with steroid-free and anticalcineurin-free regimens, in combination with another costimulation blocker, rapamycin, and an anti-interleukin 2 receptor antibody, and with a strategy directed against the recurrence of autoimmunity.
Rapid and robust phylotyping of spa t003, a dominant MRSA clone in Luxembourg and other European countries (2013)

canSNP-based PCR assays are useful for local level MRSA phylotyping, especially in the presence of one or more dominant clones. The assays designed here can be easily adapted for investigating t003 MRSA strains in other regions in Western Europe. WGST provides substantially better resolution than other typing methods.
A Learning-Based Solution for an Adversarial Repeated Game in Cyber–Physical Power Systems (2019)

Due to the rapidly expanding complexity of the cyber-physical power systems, the probability of a system malfunctioning and failing is increasing. Most of the existing works combining smart grid (SG) security and game theory fail to replicate the adversarial events in the simulated environment close to the real-life events. In this article, a repeated game is formulated to mimic the real-life interactions between the adversaries of the modern electric power system. The optimal action strategies for different environment settings are analyzed. The advantage of the repeated game is that the players can generate actions independent of the previous actions' history. The solution of the game is designed based on the reinforcement learning algorithm, which ensures the desired outcome in favor of the players. The outcome in favor of a player means achieving higher mixed strategy payoff compared to the other player. Different from the existing game-theoretic approaches, both the attacker and the defender participate actively in the game and learn the sequence of actions applying to the power transmission lines. In this game, we consider several factors (e.g., attack and defense costs, allocated budgets, and the players' strengths) that could affect the outcome of the game. These considerations make the game close to real-life events. To evaluate the game outcome, both players' utilities are compared, and they reflect how much power is lost due to the attacks and how much power is saved due to the defenses. The players' favorable outcome is achieved for different attack and defense strengths (probabilities). The IEEE 39 bus system is used here as the test benchmark. Learned attack and defense strategies are applied in a simulated power system environment (PowerWorld) to illustrate the postattack effects on the system.
Summation of Classification as an Enhancement of Intellectual Access to Information in an Online Environment (1990)

Classification structure and indexes to classifications need to be better understood before classification can be a major access point in online catalogs.
Design considerations for ultra-precision magnetic bearing supported slides (1993)

Development plans for a prototype servocontrolled machine with 1 angstrom resolution of linear motion and 50 mm range of travel are described. Two such devices could then be combined to produce a two dimensional machine for probing large planar objects with atomic resolution, the Angstrom Resolution Measuring Machine (ARMM).
A Contextual Data Mining Approach Toward Assisting the Treatment of Anxiety Disorders (2010)

Anxiety disorders are considered the most prevalent of mental disorders. Nevertheless, the exact reasons that provoke them to patients remain yet not clearly specified, while the literature concerning the environment for monitoring and treatment support is rather scarce warranting further investigation. Toward this direction, in this study a context-aware approach is proposed, aiming to provide medical supervisors with a series of applications and personalized services targeted to exploit the multiparameter contextual data collected through a long-term monitoring procedure. More specifically, an application that assists the archiving and retrieving of the patients' health records was developed, and four treatment supportive services were considered. The three of them focus on the discovery of possible associations between the patient's contextual data; the last service aims at predicting the stress level a patient might suffer from, in a given context. The proposed approach was experimentally evaluated quantitatively (in terms of computational efficiency and time requirements) and qualitatively by experts on the field of mental health domain. The feedback received was very encouraging and the proposed approach seems quite useful to the anxiety disorders' treatment.
Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria (2022)

In this small trial, L9LS administered intravenously or subcutaneously protected recipients against malaria after controlled infection, without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; VRC 614 ClinicalTrials.gov number, NCT05019729.).
Proving Skipping Refinement with ACL2s (2015)

We describe three case studies illustrating the use of ACL2s to prove the correctness of optimized reactive systems using skipping refinement. Reasoning about reactive systems using refinement involves defining an abstract, high-level specification system and a concrete, low-level system. Next, one shows that the behaviors of the implementation system are allowed by the specification system. Skipping refinement allows us to reason about implementation systems that can "skip" specification states due to optimizations that allow the implementation system to take several specification steps at once. Skipping refinement also allows implementation systems to, i.e., to take several steps before completing a specification step. We show how ACL2s can be used to prove skipping refinement theorems by modeling and proving the correctness of three systems: a JVM-inspired stack machine, a simple memory controller, and a scalar to vector compiler transformation.
Dynamical Quadratic Cavity Solitons (1999)

There is constantly growing interest in optical solitons because of their robustness and potential applications in information transmission, processing and storage schemes. Recently resting solitons were identified in scalar [1] as well as vectorial [2,3] intracavity second-harmonic generation.
One-bit ADCs in wideband massive MIMO systems with OFDM transmission (2016)

We investigate the performance of wideband massive MIMO base stations that use one-bit ADCs for quantizing the uplink signal. Our main result is to show that the many taps of the frequency-selective channel make linear combiners asymptotically consistent and the quantization noise additive and Gaussian, which simplifies signal processing and enables the straightforward use of OFDM. We also find that single-carrier systems and OFDM systems are affected in the same way by one-bit quantizers in wideband systems because the distribution of the quantization noise becomes the same in both systems as the number of channel taps grows.
End-fire Substrate Extended Metasurface Antenna Array for mm-Wave Applications (2019)

This paper presents a 1 ×8 SIW fed endfire metasurface antenna array operating from 28 GHz to 37 GHz. A single end-fire SIW-fed substrate extended metasurface antenna is first designed, which has a bandwidth of 25-39.5 GHz. This metasurface antenna is utilized to construct a 1 ×8 linear array with a SIW power divider. The characteristics of the proposed antenna array are thoroughly investigated. The simulated gain of the array varies between 11.8 and 17.3 dBi over 28-37 GHz. The wide bandwidth and high gain of the proposed 1 ×8 metasurface antenna array makes it an excellent candidate for future mmWave applications.
Synthesis of Solvents for Water Desalination: Amines and Ethers. (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Solvents for Water Desalination: Amines and Ethers.A. F. Isbell and D. W. HoodCite this: J. Chem. Eng. Data 1962, 7, 4, 575–580Publication Date (Print):October 1, 1962Publication History Published online1 May 2002Published inissue 1 October 1962https://pubs.acs.org/doi/10.1021/je60015a044https://doi.org/10.1021/je60015a044research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Internalization of the E-Cadherin/Catenin Complex and Scattering of Human Mammary Carcinoma Cells MCF-7/AZ after Treatment with Conditioned Medium from Human Skin Squamous Carcinoma Cells COLO 16 (2000)

Cytokines and other paracrine or autocrine factors functionally modulate the invasion-suppressor and signal-transducing E-cadherin/catenin complex. We have used conditioned medium from human squamous carcinoma COLO 16 cells (CM COLO 16) as a source of such factors to modulate the E-cadherin/catenin complex in human breast carcinoma MCF-7 cells. CM COLO 16 induces scattering of MCF-7/AZ, but not of MCF-7/6 cells on tissue culture plastic substratum, and reduces aggregation of MCF-7/AZ cells in suspension. Insulin-like growth factor I counteracts this reduction of aggregation. Confocal laser scanning microscopy of immunocytochemical stainings shows loss of the honeycomb pattern of E-cadherin, alpha-catenin and beta-catenin, and internalization of those elements. Cell surface biotinylation shows a decrease in membrane-bound E-cadherin. Immunoprecipitation and cell fractionation show that the composition of the complex is maintained. Interleukin-1, interleukin-6, granulocyte-monocyte colony stimulating factor, stem cell factor, scatter factor/hepatocyte growth factor and transforming growth factor-beta, added separately to MCF-7/AZ cells, could not mimic the effects of CM COLO 16. Neither could we find evidence that the 80 kDa extracellular fragment of E-cadherin is implicated in scattering of MCF-7/AZ cells. This fragment is present in CM COLO 16, but it is also produced by the MCF-7/AZ cells themselves, even at higher levels. Our data point toward cytoplasmic internalization induced by paracrine factors as one of the downregulating mechanisms for the E-cadherin/catenin complex.
Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur (2015)

Decreased brain content of DHA, the most abundant long-chain n-3 polyunsaturated fatty acid (n-3 LCPUFA) in the brain, is accompanied by severe neurosensorial impairments linked to impaired neurotransmission and impaired brain glucose utilization. In the present study, we hypothesized that increasing n-3 LCPUFA intake at an early age may help to prevent or correct the glucose hypometabolism observed during aging and age-related cognitive decline. The effects of 12 months' supplementation with n-3 LCPUFA on brain glucose utilization assessed by positron emission tomography was tested in young adult mouse lemurs (Microcebus murinus). Cognitive function was tested in parallel in the same animals. Lemurs supplemented with n-3 LCPUFA had higher brain glucose uptake and cerebral metabolic rate of glucose compared with controls in all brain regions. The n-3 LCPUFA-supplemented animals also had higher exploratory activity in an open-field task and lower evidence of anxiety in the Barnes maze. Our results demonstrate for the first time in a nonhuman primate that n-3 LCPUFA supplementation increases brain glucose uptake and metabolism and concomitantly reduces anxiety.
In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM. (1994)

SPECT imaging of [123I]IBVM succeeds as an in vivo measure of cholinergic neuronal integrity and should be useful for the study of cerebral degenerative processes such as Alzheimer's disease.
Performance-Based Measures of Functional Skills: Usefulness in Clinical Treatment Studies (2007)

Recently, attention to the assessment and treatment of functional disability has increased notably. It is widely understood that impairments in everyday living skills, including independent living skills, social functions, vocational functioning, and self-care, are present in people with schizophrenia. It has also become clear recently that assessment of these skills can pose substantial challenges. These challenges include selection of meaningful short-term outcome measures and avoiding bias and reduced validity in the data. Self-report, direct observation, and informant reports of everyday disability all have certain advantages but appear to be inferior to direct assessment of skills with performance-based measures. This review outlines the issues associated with the assessment of functional skills and everyday functioning and provides a description of the strengths and weaknesses of these approaches. We conclude that direct assessment of functional capacity has substantial advantages over other measures and may actually provide a more direct and valid estimate of functional disability than performance on the more distal neuropsychological assessment measures.