gebhart/patrepeval huggingface dataset:
Escherichia coli imidazoleglycerol phosphate dehydratase: spectroscopic characterization of the enzymic product and the steric course of the reaction (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEscherichia coli imidazoleglycerol phosphate dehydratase: spectroscopic characterization of the enzymic product and the steric course of the reactionAulma R. Parker, Jeffrey A. Moore, John M. Schwab, and V. Jo DavissonCite this: J. Am. Chem. Soc. 1995, 117, 43, 10605–10613Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00148a001https://doi.org/10.1021/ja00148a001research-articleACS PublicationsRequest reuse permissionsArticle Views708Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Acute Megakaryoblastic Leukemia in a Dog (2015)

12歳，去勢雄の雑種犬が跛行と元気消失を主訴に来院した．血液塗抹では芽球様細胞が観察され，針生検にて骨髄及び脾臓に巨核球様芽球細胞の著しい増殖が認められた．同細胞はフローサイトメトリー（FCM）にて，血小板及び巨核球に発現するCD41/CD61抗原に陽性を示すことから，巨核球系細胞に由来することが示され，本症例は急性巨核芽球性白血病（AML-M7）と診断された．プレドニゾロン投与により一般状態は改善が認められたものの，貧血及び血小板減少が急速に進行したため，L-アスパラギナーゼ投与及び全血輸血に反応せず，第26病日に死亡した．
Threshold RSA for Dynamic and Ad-Hoc Groups. (2008)

Abstract. We consider the use of threshold signatures in ad-hoc and dynamic groups such as MANETs (“mobile ad-hoc networks”). While the known threshold RSA signature schemes have several properties that make them good candidates for deployment in these scenarios, none of these schemes seems practical enough for realistic use in these highly-constrained environments. In particular, this is the case of the most efficient of these threshold RSA schemes, namely, the one due to Shoup. Our contribution is in presenting variants of Shoup’s protocol that overcome the limitations that make the original protocol unsuitable for dynamic groups. The resultant schemes provide the efficiency and flexibility needed in ad-hoc groups, and add the capability of incorporating new members (share-holders) to the group of potential signers without relying on central authorities. Namely, any threshold of existing members can cooperate to add a new member. The schemes are efficient, fully non-interactive and do not assume broadcast. 1
SUMOylation inhibits FOXM1 activity and delays mitotic transition (2013)

The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation is enhanced in MCF-7 breast cancer cells in response to treatment with epirubicin and mitotic inhibitors. Mutation of five consensus conjugation motifs yielded a SUMOylation-deficient mutant FOXM1. Conversely, fusion of the E2 ligase Ubc9 to FOXM1 generated an auto-SUMOylating mutant (FOXM1-Ubc9). Analysis of wild-type FOXM1 and mutants revealed that SUMOylation inhibits FOXM1 activity, promotes translocation to the cytoplasm and enhances APC/Cdh1-mediated ubiquitination and degradation. Further, expression of the SUMOylation-deficient mutant enhanced cell proliferation compared with wild-type FOXM1, whereas the FOXM1-Ubc9 fusion protein resulted in persistent cyclin B1 expression and slowed the time from mitotic entry to exit. In summary, our findings suggest that SUMOylation attenuates FOXM1 activity and causes mitotic delay in cytotoxic drug response.
A study of non-uniform pilot spacing for PSAM (2002)

Pilot symbol assisted modulation (PSAM) achieves coherent demodulation in a fading environment by inserting known symbols into the data stream. The receiver uses these pilot symbols to estimate its amplitude and phase reference. Although the pilots are typically spaced uniformly, adding extra consecutive pilot symbols allows one to estimate a large frequency offset on the channel. This work uses computer simulations to investigate the bit error probability (BEP) of PSAM with various non-uniform frame structures. It is shown that for higher Doppler rates, a non-uniform frame structure yields a lower BEP than a comparable uniform frame. Furthermore, in the presence of an unknown frequency offset, a non-uniform frame performs much better because it can estimate and remove the frequency offset prior to compensating for the fading process.
Parenteral and enteral nutrition in surgical critical care (2017)

Therapeutic study, level III; prognostic study, level II.
Disposable Carbon Dots Modified Screen Printed Carbon Electrode Electrochemical Sensor Strip for Selective Detection of Ferric Ions (2017)

A disposable electrochemical sensor strip based on carbon nanodots (C-Dots) modified screen printed carbon electrode (SPCE) was fabricated for selective detection of ferric ions (Fe 3+ ) in aqueous solution. C-Dots of mean diameters within the range of 1–7 nm were synthesized electrochemically from spent battery carbon rods. The analytical performance of this electrochemical sensor strip was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The deposition of C-Dots had enhanced the electron-transfer kinetics and current intensity of the SPCE remarkably by 734% as compared to that of unmodified SPCE. Under optimized conditions, the electrochemical sensor strip exhibited a linear detection range of 0.5 to 25.0 ppm Fe 3+ with a limit of detection (LOD) of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">0.44</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">0.04</mml:mn></mml:math> ppm (at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>S</mml:mi><mml:mo>/</mml:mo><mml:mi>N</mml:mi></mml:math> ratio = 3). Validation of results by the electrochemical sensor strip was done by comparing analysis results obtained using an Atomic Absorption Spectrometer (AAS).
MR proton spectroscopy in multiple sclerosis. (1992)

Based upon these observations we infer that 1) the majority of enhancing lesions are demyelinating with extra peaks at 2.1-2.6 ppm representing a marker of this process, 2) enhancing lesions without this marker most likely represent edematous regions without significant demyelination, and 3) demyelination may be long in duration compared with transient blood-brain barrier disruption manifested by Gd-DTPA enhancement. Our results suggest that 1H spectroscopy has the ability to further categorize MR-demonstrated enhancing and unenhancing lesions in patients with multiple sclerosis and that it may be more sensitive than contrast enhancement in revealing the true time course of demyelination.
Ab initio derived force‐field parameters for molecular dynamics simulations of deprotonated amorphous‐SiO2/water interfaces (2011)

Abstract We present a set of Coulomb point charges and van der Waals parameters for molecular dynamics simulations of interfaces between natively deprotonated amorphous SiO 2 surfaces and liquid water, to be used in combination with standard biomolecular force fields. We pay particular attention to the extent of negative charge delocalisation in the solid that follows the deprotonation of terminal silanol groups, as revealed by extensive Bader analysis of electronic densities computed by density functional theory (DFT). The absolute charge values in our force field are determined from best‐fitting to the electrostatic potential computed ab initio (ESP charges). Our proposed parameter set is found to reproduce the energy landscape of single water molecules over neutral and deprotonated amorphous SiO 2 surfaces and, after a minor adjustment, over thin oxide films on Si. Our analysis reveals a certain degree of arbitrariness in the choice of the DFT scheme used as the reference for the force‐field optimisation procedure, highlighting its intrinsic limits. magnified image Interaction between a water molecule and an oxidised Si surface calculated with several DFT and force‐field schemes, and delocalisation of the negative charge upon deprotonation of an amorphous SiO 2 surface.
Towards a cooperative design methodology : analysis of sequential decision strategies (1991)

Includes bibliographical references (p. 22-24).
Direct transmesenteric venous interventions in the acute post liver transplant setting (2020)

The advantages of direct SMV access with the surgery team include direct approach to accessing thrombus, sparing of liver parenchyma, and significant hemostatic control.
Visual Measurement in Simulation Environment for Vision-Based UAV Autonomous Aerial Refueling (2015)

Autonomous aerial refueling (AAR) is an important capability of unmanned aerial vehicles (UAVs) for further applications in both military and civilian domains. This paper focuses on the description and comparison of visual measurement strategies in the simulation environment of AAR of UAVs. The visual measurement methods are employed for pose estimation between tanker and UAV receiver aircrafts. Within this effort, methods and techniques for marker detection, pose estimation, and visualization of aerial refueling in virtual reality have been designed and implemented. Series of comparative experiments indicate the preference of various visual measurement approaches in our work. Boom and stationkeeping controllers are designed to ensure system stability when wind turbulence is induced. Furthermore, the hardware-in-loop simulation platform is built to demonstrate the feasibility and effectiveness of the proposed scenarios in actual conditions. The visual attention mechanism is adopted in the preprocessing for the images of virtual scene to remove potential noises. The achieved results make excellent performances of our proposed scheme during the docking maneuver in AAR.
Airborne Optical and Thermal Remote Sensing for Wildfire Detection and Monitoring (2016)

For decades detection and monitoring of forest and other wildland fires has relied heavily on aircraft (and satellites). Technical advances and improved affordability of both sensors and sensor platforms promise to revolutionize the way aircraft detect, monitor and help suppress wildfires. Sensor systems like hyperspectral cameras, image intensifiers and thermal cameras that have previously been limited in use due to cost or technology considerations are now becoming widely available and affordable. Similarly, new airborne sensor platforms, particularly small, unmanned aircraft or drones, are enabling new applications for airborne fire sensing. In this review we outline the state of the art in direct, semi-automated and automated fire detection from both manned and unmanned aerial platforms. We discuss the operational constraints and opportunities provided by these sensor systems including a discussion of the objective evaluation of these systems in a realistic context.
High-Mobility AlGaN/GaN Two-Dimensional Electron Gas Heterostructure Grown on (111) Single Crystal Diamond Substrate (2010)

High mobility Al 0.28 Ga 0.72 N/GaN two-dimensional electron gas (2DEG) is achieved on (111) oriented single crystal diamond substrate. The surface morphology of the epilayer is free of cracks thanks to the use of an AlN interlayer for strain relaxation. The rms roughness of the sample surface deduced from atomic force microscopy is 0.6 nm for a 2 ×2 µm 2 scan area, which indicates an excellent surface morphology. Hall effect measurements reveal a 2DEG with room temperature mobility and sheet carrier density of 750 cm 2 V -1 s -1 and 1.4 ×10 13 cm -2 , respectively. These results compare fairly well with AlGaN/GaN 2DEG characteristics obtained on other substrates like silicon and demonstrate that high power electronics can be developed on diamond substrates with high power dissipation capabilities.
Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virus (2018)

Abstract The emergence of drug resistance in avian influenza virus (AIV) is a serious concern for public health. Neuraminidase (NA) isolated from a fatal case of avian-origin H10N8 influenza virus infection was found to carry a drug-resistant mutation, NA-Arg292Lys (291 in N8 numbering). In order to understand the full potential of H10N8 drug resistance, the virus was first passaged in the presence of the most commonly used neuraminidase inhibitors (NAIs), oseltamivir and zanamivir. As expected, the Arg292Lys substitution was detected after oseltamivir treatment, however a novel Val116Asp substitution (114 in N8 numbering) was selected by zanamivir treatment. Next generation sequencing (NGS) confirmed that the mutations arose early (after passages 1-3) and became dominant in the presence of the NAI inhibitors. Extensive crystallographic studies revealed that N8-Arg292Lys resistance results mainly from loss of interactions with the inhibitor carboxylate, while rotation of Glu276 was not impaired as observed in the N9-Arg292Lys, a group 2 NA structure. In the case of Val116Asp, the binding mode between oseltamivir and zanamivir is different. Asp151 forms stabilized hydrogen bond to guanidine group of zanamivir, which may compensate the resistance caused by Val116Asp. By contrast, the amino group of oseltamivir is too short to maintain this hydrogen bond, which result in resistant. Moreover, the oseltamivir-zanamivir hybrid inhibitor MS-257 displays higher effectiveness to Val116Asp than oseltamivir, which support this notion. Author Summary Aside from vaccination, NAIs are currently the only alternative for the clinical treatment and prophylaxis of influenza. Understanding the mechanisms of resistance is critical to guide in drug development. In this study, two drug-resistant NA substitutions, Val116Asp and Arg292Lys, were discovered from oseltamivir and zanamivir treatment of H10N8 virus. Crystal structural analyses revealed two distinct mechanisms of these two resistant mutations and provide the explanation for the difference in susceptibility of different NAIs. Zanamivir and laninamivir were more effective against the resistant variants than oseltamivir, and Arg292Lys results in more serious oseltamivir resistance in N9 than N8 subtype. This study is well-correlated to influenza pandemic/epidemic pre-warning, as the discovery of inhibitor resistant viruses will help for new drug preparedness.
The Input Configurator toolkit (2004)

This article describes ICON (Input Configurator), an input management system that enables interactive applications to achieve a high level of input adaptability. We define input adaptability as the ability of an interactive application to exploit alternative input devices effectively and offer users a way of adapting input interaction to suit their needs. We describe several examples of interaction techniques implemented using ICON with little or no support from applications that are hard or impossible to implement using regular GUI toolkits.
Immunosuppression of thyroiditis. (1996)

Immunization of mice with 50 micrograms human thyroglobulin (TG) in complete Freund's adjuvant leads to histological thyroiditis; production of IgG, IgA, and IgM anti-TG antibodies; and in vitro proliferative responses after incubation of lymphocytes with TG. Oral administration of 500 micrograms TG at four intervals before Tg immunization and once afterward causes up to 80% suppression of these responses. The effect is antigen specific and dose dependent. Feeding TG after immunization produces a 40% reduction in responses. We wished to define the mechanism of this antigen-specific oral tolerization. Popliteal lymph nodes (PLN) of orally tolerized animals (T) are reduced in size compared to those in immunized (I) animals not fed TG. PLN and mesenteric lymph nodes (MLN) of I animals produce interleukin-2 (IL-2) and interferon-gamma (IFN gamma) after in vitro incubation with TG, typical of an inflammatory immune response. PLN and MLN of tolerized animals do not proliferate in response to antigen, do not produce IL-2 or IFN gamma, but do not produce the cytokines IL-4 and transforming growth factor-beta (TGF beta). Mixing in vitro of spleen cells from T and I animals causes a reduction in the immune response when incubated with TG, but no reduction in response to purified protein derivative (PPD) (the antigen in complete Freund's adjuvant). When T splenocytes are incubated with TG and PPD together, the response to TG and PPD is suppressed. Partially purified CD8+ cells from tolerized animals produce IL-4 and TGF beta after exposure to human TG and induce suppression, whereas partially purified CD4+ cells produce IL-2 and IFN gamma and do not cause suppression. MLN cells do not proliferate in response to antigen, but do produce inhibitory cytokines. T animals appear to shift the immune response from a Th-1 helper cell subset response to a Th-2 helper cell immunosuppressive response. In this model, oral tolerization produces a dramatic reduction in the immune response. Exposure of MLN to oral TG appears to cause the production of regulatory cells that migrate to spleen and PLN. In vitro studies demonstrate that on exposure to antigen, these regulatory cells produce IL-4 and TGF beta, which suppress all aspects of specific immune responsiveness and nonspecifically suppress other ongoing immune responses (bystander effect). Oral tolerization may include some element of T cell deletion or anergy. This model defines an experimental system with possible relevance to immunosuppression of human autoimmune thyroid disease.
Intelligent vehicle clusters (Inside Com2React project) (2009)

The intelligent vehicle clusters concept has been introduced and developed in the Com2React project to overcome some of the limitations of the former REACT research project. Cluster of vehicles together with the regional control center constitute a hierarchical traffic information and communication structure where vehicles on the local level are mainly self-organised but then additionally controlled by the traffic management system on the regional level. The main challenge was to secure the achievements and benefits of the REACT applications and to find a new balance for efficient data processing, communication and utilisation between the different entities in the overall system. The aim here is to give a brief review and analysis of the most important features and benefits of this concept.
Coherent optical communication using polarization multiple-input-multiple-output (2005)

Polarization-division multiplexed (PDM) optical signals can potentially be demultiplexed by coherent detection and digital signal processing without using optical dynamic polarization control at the receiver. In this paper, we show that optical communications using PDM is analogous to wireless communications using multiple-input-multiple-output (MIMO) antennae and thus algorithms for channel estimation in wireless MIMO can be ready applied to optical polarization MIMO (PMIMO). Combined with frequency offset and phase estimation algorithms, simulations show that PDM quadrature phase-shift keying signals can be coherently detected by the proposed scheme using commercial semiconductor lasers while no optical phase locking and polarization control are required. This analogy further suggests the potential application of space-time coding in wireless communications to optical polarization MIMO systems and relates the problem of polarization-mode dispersion in fiber transmission to the multi-path propagation in wireless communications.
A Horizontal Gene Transfer Event Defines Two Distinct Groups within Burkholderia pseudomallei That Have Dissimilar Geographic Distributions (2007)

Burkholderia pseudomallei is the etiologic agent of melioidosis. Many disease manifestations are associated with melioidosis, and the mechanisms causing this variation are unknown; genomic differences among strains offer one explanation. We compared the genome sequences of two strains of B. pseudomallei: the original reference strain K96243 from Thailand and strain MSHR305 from Australia. We identified a variable homologous region between the two strains. This region was previously identified in comparisons of the genome of B. pseudomallei strain K96243 with the genome of strain E264 from the closely related B. thailandensis. In that comparison, K96243 was shown to possess a horizontally acquired Yersinia-like fimbrial (YLF) gene cluster. Here, we show that the homologous genomic region in B. pseudomallei strain 305 is similar to that previously identified in B. thailandensis strain E264. We have named this region in B. pseudomallei strain 305 the B. thailandensis-like flagellum and chemotaxis (BTFC) gene cluster. We screened for these different genomic components across additional genome sequences and 571 B. pseudomallei DNA extracts obtained from regions of endemicity. These alternate genomic states define two distinct groups within B. pseudomallei: all strains contained either the BTFC gene cluster (group BTFC) or the YLF gene cluster (group YLF). These two groups have distinct geographic distributions: group BTFC is dominant in Australia, and group YLF is dominant in Thailand and elsewhere. In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model.