gebhart/patrepeval huggingface dataset:
DEVELOPMENT OF A NEW STRATEGY FOR MINIMIZING ISLET CELL MASS IN TYPE 1 DIABETIC RECIPIENTS: DIANNEXIN REDUCES PROAPOPTOTIC BID, PROMOTES ANTI-INFLAMMATORY INTERLEUKIN-10 AND IMPROVES EARLY GRAFT FUNCTION IN THE MARGINAL ISLET MASS TRANSPLANTATION MODEL (2010)

Cheng, E.; Yang, H.; Sharma, V.; Lagman, M.; Leeser, D.; Suthanthiran, M. Author Information
Output Feedback Stabilization with Nonlinear Predictive Control: Asymptotic properties (2003)

State space based nonlinear model predictive control (NM PC) needs the state for the prediction of the system behaviour. Unfortunately, for most applications, not all states are directly measurable. To recover the unmeasured states, typically a stable state observer is used. However, this implies that the stability of the closed-loop should be examined carefully, since no general nonlinear separation principle exists. Recently semi-global practical stability results for output feedback NMPC using a high-gain observer for state estimation have been established. One drawback of this result is that (in general) the observer gain must be increased, if the desired set the state should converge to is made smaller. We show that under slightly stronger assumptions, not only practical stability, but also convergence of the system states and observer error to the origin for a sufficiently large but bounded observer gain can be achieved.
Plasma triglyceride determines structure-composition in low and high density lipoproteins. (1984)

Because the association of hypertriglyceridemia and premature atherosclerosis is not due to the direct effects of the triglyceride molecule itself, we studied the effects of increased plasma triglyceride-rich lipoproteins on the composition and structure of low density lipoprotein (LDL) and high density lipoprotein (HDL). We found profound changes in the core and surface domains of both lipoproteins with increasing triglyceridemia. Core cholesterol esters were progressively depleted and replaced by triglyceride molecules. Highly significant negative correlations were found between cholesterol ester/protein ratios (r = -0.64 for LDL and -0.58 for HDL (p less than 0.001); positive correlations were found for triglyceride/protein ratios (r = 0.62 for LDL and 0.58 for HDL) and for triglyceride/cholesterol ester ratios (r = 0.70 for LDL and 0.83 for HDL) when these variables were assayed as a function of plasma triglyceride concentrations. With severe hypertriglyceridemia, triglyceride/cholesterol ester ratios of more than 1.0 were consistently observed (normal, less than 0.02). This leads to an underestimation of LDL and HDL levels when cholesterol alone is measured. At the surface, LDL and HDL were depleted of phospholipid and free cholesterol, with a relative enrichment of protein. These changes can be explained on the basis of high levels of plasma triglyceride-rich lipoproteins serving as acceptors for cholesterol esters and other constituents from LDL and HDL. Concomitantly, triglycerides are transferred to LDL and HDL. These transfer processes are likely to be mediated by the activity of lipid transfer proteins present in human plasma.
A 5 V only one-transistor 256 K EEPROM with page-mode erase (1989)

Erasing and programming are achieved in the device through electron tunneling. In order to inhibit the programming to unselected cells, the unselected bit lines and word lines are applied with program-inhibiting voltages. The number of parity bits for error checking and correction (ECC) is fiver per 2 bytes, which are controlled by the lower byte (LB) signal. Using a conventional 1.5 mu m design rule n-well CMOS process with a single metal layer and two polysilicon layers, the memory cell size is 7*8 mu m/sup 2/ and the chip size is 5.55*7.05 mm/sup 2/. The chip size is reduced to 70% of a full-featured electrically erasable programmable ROM (EEPROM) with on-chip ECC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A fractional fourier domain approach for multiple target localization using the time-of-arrival (2017)

In this paper, a parameter estimation method for localizing multiple targets in the three-dimensional region using as few as four sensor elements is presented. It is designed based on the properties of chirp signals in fractional Fourier domains and it provides good separation to closely spaced targets. Besides that, a notable advantage of the proposed method over existing methods is its capability in detecting and localizing more targets than the number of sensors.
Graphene oxide based BCNO hybrid nanostructures: tunable band gaps for full colour white emission (2014)

We report the optimal conversion of graphene oxide (GO) into white-lighting BCNO hybrid nanostructures by a one-step air oxidation process with the aid of boric acid and urea.
Analysis of diffential absorption lidar technique for measurements of anhydrous hydrogen chloride from solid rocket motors using a deuterium fluoride laser (1977)

An active optical technique (differential absorption lidar (DIAL)) for detecting, ranging, and quantifying the concentration of anhydrous HCl contained in the ground cloud emitted by solid rocket motors (SRM) is evaluated. Results are presented of an experiment in which absorption coefficients of HCl were measured for several deuterium fluoride (DF) laser transitions demonstrating for the first time that a close overlap exists between the 2-1 P(3) vibrational transition of the DF laser and the 1-0 P(6) absorption line of HCl, with an absorption coefficient of 5.64 (atm-cm) to the -1 power. These measurements show that the DF laser can be an appropriate radiation source for detecting HCl in a DIAL technique. Development of a mathematical computer model to predict the sensitivity of DIAL for detecting anhydrous HCl in the ground cloud is outlined, and results that assume a commercially available DF laser as the radiation source are presented.
Multiparametric immune profiling in HPV– oral squamous cell cancer (2017)

Evaluation of T lymphocyte frequency provides prognostic information for patients with oral squamous cell cancer (OSCC). However, the effect of simultaneously evaluating T cell frequency and assessing suppressive elements and defects in antigen-processing machinery (APM) has not been clarified. Simultaneous characterization of CD3+, CD8+, FoxP3+, CD163+, and PD-L1+ cells using multispectral imaging was performed on sections from 119 patients with HPV- OSCC. Expression of β2-microglobulin, MHC class I heavy chain, and large multifunctional peptidase 10 was quantified, and all data were correlated with patient outcome. We found that, consistent with previous reports, high numbers of CD8+ T cells at the invasive margin correlated significantly with prolonged overall survival (OS), while the number of FoxP3+ or PD-L1+ cells did not. Compiling the number of FoxP3+ or PD-L1+ cells within 30 μm of CD8+ T cells identified a significant association with a high number of suppressive elements close to CD8+ T cells and reduced OS. Integrating this information into a cumulative suppression index (CSI) increased correlation with OS. Incorporating tumor expression levels of APM components with CSI further improved prognostic power. This multiparametric immune profiling may be useful for stratifying patients with OSCC for clinical trials.
Systematic Experimental Validation of High-Order Spectral Method for Deterministic Wave Prediction (2019)

Abstract The applicability of the High-Order Spectral Method (HOSM) as a very fast non-linear method for deterministic short-term wave prediction is discussed within this paper. The focus lies on the systematic experimental validation of the HOSM in order to identify and evaluate possible areas of application as well as limitations of use. For this purpose, irregular sea states with varying parameters such as wave steepness and underlying wave spectrum are addressed by numerical simulations and model tests in the controlled environment of a seakeeping basin. In addition, the influence of the propagation distance is discussed. For the evaluation of the accuracy of the HOSM prediction, the surface similarity parameter (SSP) is utilized, allowing a quantitative validation of the results. The results obtained are compared to linear wave prediction to discuss the pros and cons of a non-linear deterministic short-term wave prediction. In conclusion, this paper shows that the non-linear deterministic wave prediction based on HOSM leads to a substantial improvement of the prediction quality for moderate and steep irregular wave trains in terms of individual waves and prediction distance.
Many-bodyGWcalculation of the oxygen vacancy in ZnO (2010)

Density-functional theory (DFT) calculations of defect levels in semiconductors based on approximate functionals are subject to considerable uncertainties, in particular due to inaccurate band-gap energies. Testing previous correction methods by many-body $GW$ calculations for the O vacancy in ZnO, we find that: (i) The $GW$ quasiparticle shifts of the ${V}_{\text{O}}$ defect states increase the spitting between occupied and unoccupied states due to self-interaction correction, and do not reflect the conduction- versus valence-band character. (ii) The $GW$ quasiparticle energies of charged defect states require important corrections for supercell finite-size effects. (iii) The $GW$ results are robust with respect to the choice of the underlying DFT or hybrid-DFT functional, and the $(2+/0)$ donor transition lies below midgap, close to our previous prediction employing rigid band-edge shifts.
Master buoy system for acoustic array deployment, using underwater glide bodies remotely launched from a submerged pod (1981)

First Page
THE SYNTHESIS OF D-glycero-L-altro-HEPTOSE, D-glycero-L-allo-HEPTOSE, AND meso-glycero-altro-HEPTITOL (1966)

Condensation of D-talose with nitromethane in alkaline methanol gave the corresponding epimeric 1-deoxy-1-nitroheptitols which were converted into D-glycero-L-altro-heptose and D-glycero-L-allo-heptose (1.5:1) in 44% yield. Reduction of D-glycero-L-altro-heptose with sodium borohydride gave the hitherto unknown meso-glycero-altro-heptitol. The gas–liquid chromatography retention times of the 10 geometrically isomeric heptitol heptaacetates were determined. These data provide the necessary information for the key step in a procedure for the rapid identification of an unknown heptose.
HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger (2017)

Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by <i>Karlodinium armiger</i>, was quantified in laboratory-grown cultures using high-performance liquid chromatography (HPLC) coupled to electrospray ionisation high-resolution time-of-flight mass spectrometry (HRMS). Prior to the quantification of karmitoxin, a standard of karmitoxin was purified from <i>K. armiger</i> cultures (80 L). The standard was quantified by fluorescent derivatisation using Waters AccQ-Fluor reagent and derivatised fumonisin B₁ and fumonisin B₂ as standards, as each contain a primary amine. Various sample preparation methods for whole culture samples were assessed, including six different solid phase extraction substrates. During analysis of culture samples, MS source conditions were monitored with chloramphenicol and valinomycin as external standards over prolonged injection sequences (>12 h) and karmitoxin concentrations were determined using the response factor of a closely eluting iturin A2 internal standard. Using this method the limit of quantification was 0.11 μg·mL<sup>-1</sup>, and the limit of detection was found to be 0.03 μg·mL<sup>-1</sup>. Matrix effects were determined with the use of <i>K. armiger</i> cultures grown with <sup>13</sup>C-labelled bicarbonate as the primary carbon source.
Efficient fault tolerance approaches for parallel architectures solving linear and nonlinear algorithms (1995)

VLSI-based processor arrays have been widely used for computation intensive applications such as matrix computations, FFT, and graph problems. In these systems, fault tolerance is a primary concern because even a single fault can cause a catastrophic outcome. In this dissertation, an efficient algorithm-based fault tolerance design employing a new checksum coding technique is first examined to solve matrix computations. Comparisons with other schemes reveal that the proposed scheme is very efficient in terms of time and hardware overhead.
Two new concurrent error detection schemes for FFT networks are then proposed. The first scheme calculating the checksums at the input and output site allows high error coverage with low false alarm rate by applying the linear weight factors to the checksums. Hardware overhead is relatively small and errors can be quickly detected. In the second scheme which computes the checksums in each stage, multiple errors can be efficiently and promptly detected. Fault coverage is almost 100% for any size FFT networks with very small hardware overhead. Efficient error location and correction schemes for FFT networks are also proposed, which can be used along with any error detection schemes employing the checksum approaches. A faulty component can be located at an additional try with smaller number of comparisons than existing designs. An error can also be corrected at a small modification of basic modules with an additional try.
A generalized fault tolerance approach for two-dimensional processor arrays is then presented. The proposed approach can effectively tolerate multiple faults in the array solving linear or nonlinear algorithms by properly scheduling the flow of data and employing the majority voting approach. Most earlier fault tolerance designs are restricted to the array solving linear algorithms. Hardware overhead is almost zero in the approach compared to nonfault tolerant designs, while small time overhead much less than 100% is needed. The number of I/O links is also reduced to about $2\over 3$ of the original nonfault tolerant array. In addition, an efficient scheme is developed, which allows a signficant reduction of the size of the array without affecting the original computation time.
ChemInform Abstract: Naphthyridines. Structure, Physicochemical Properties, and General Methods of Synthesis (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analytical Solutions for Productivity Evaluation of Multifractured Wells in Multilayered and Bounded Reservoirs (1999)

Abstract We propose a semi-analytical model to represent the transient and pseudo-steady state behavior of hydraulic fractures in multilayered reservoirs where cross-flow is permitted between layers. Fractures can be horizontal or vertical. We only consider vertical fractures which are parallel to x or y axes. Fractures are fully or partially penetrating in the formation and can extend across several layers. We consider single or multiple fractures where influence between each other is modeled. The reservoir is bounded by plane surface perpendicular to the main axes, and we can impose on these limits either no-flow, constant pressure or mixed boundary conditions. The solutions are obtained from plane (zero thickness) source solutions developed in the Laplace-Fourier domain. Basquet et al.1 already used this method for the determination of point source solutions, the reasoning is still based on the « quadripole » method to account for layer cross-flow and on the Fourier transform to describe boundary effects. Vertical line source solutions are developed and are then integrated over the horizontal fracture extension to obtain the plane source solution under the assumption of uniform flux solution. The infinite conductivity solution is obtained by splitting the fractures into basic slabs with uniform flux and solving a linear system. The solution is validated against existing analytical solutions (using concept of instantaneous sources and Green's functions) modeling vertical or horizontal fractures in single layer reservoir. To check that the cross-flow between layers is well represented, we compared our vertical line source transient solution versus well known analytical solutions in multilayered reservoirs.
Sensitivity analysis in differentially private machine learning using\n hybrid automatic differentiation (2021)

In recent years, formal methods of privacy protection such as differential\nprivacy (DP), capable of deployment to data-driven tasks such as machine\nlearning (ML), have emerged. Reconciling large-scale ML with the closed-form\nreasoning required for the principled analysis of individual privacy loss\nrequires the introduction of new tools for automatic sensitivity analysis and\nfor tracking an individual's data and their features through the flow of\ncomputation. For this purpose, we introduce a novel \\textit{hybrid} automatic\ndifferentiation (AD) system which combines the efficiency of reverse-mode AD\nwith an ability to obtain a closed-form expression for any given quantity in\nthe computational graph. This enables modelling the sensitivity of arbitrary\ndifferentiable function compositions, such as the training of neural networks\non private data. We demonstrate our approach by analysing the individual DP\nguarantees of statistical database queries. Moreover, we investigate the\napplication of our technique to the training of DP neural networks. Our\napproach can enable the principled reasoning about privacy loss in the setting\nof data processing, and further the development of automatic sensitivity\nanalysis and privacy budgeting systems.\n
195-W Continuous Wave Laser Emission at 2.09 µm from a Tm3+,Ho3+-Codoped Single-Oscillator Monolithic Fiber Laser (2020)

We report on a high efficiency (45%) single-oscillator monolithic Tm 3+ , Ho 3+ -codoped fiber laser emitting 195 W at 2.09 µm in CW mode of operation, with a beam quality near the diffraction limit (M2 = 1.08).
Most continuous and increasing functions have two different fixed points (2022)

"We study the space of all continuous and increasing self-mappings of the real interval $[0,1]$ equipped with the topology of uniform convergence. In particular, we show that most such functions have at least two different fixed points."
Establecimiento de cubiertas vegetales en parcelas de producción integrada de cítricos (2000)

Con objeto de estudiar su adaptacion a las condiciones edafoclimaticas de la zona, en 1998 se establecieron cinco parcelas experimentales con distintas mezclas de gramineas y leguminosas junto a una parcela de vegetacion autoctona y otra de suelo desnudo con tratamientos herbicidas. Se ha realizado un seguimiento en las diferentes parcelas, identificando en cada caso las especies presentes y cuantificando los porcentajes de ocupacion e invasion. Las cubiertas vegetales que han presentado mejores resultados han sido la mezcla Festuca-Poa, con un elevado porcentaje de ocupacion y baja invasion de flora autoctona, crecimiento relativamente escaso y buena aptitud de resiembre, y el Agropyrum, con porcentajes de ocupacion e invasion no tan favorables como la mezcla anterior pero presentando buena rusticidad.
Hot hearts in the Sonoran desert: The 11th Weinstein cardiovascular development conference in Tucson (2005)

The 11th Annual Weinstein Cardiovascular Development Conference was held May 19-22, 2005 at the Westward Look Resort and Conference Center in Tucson, Arizona. The Westward Look was the site of the 6th Weinstein Meeting in 1999, and this year, 330 basic research scientists and research clinicians returned to Tucson for 3 days of meetings, Mariachis, and margaritas. The meeting was hosted by the cardiovascular research group at the University of Arizona and offered flavors of the desert southwest that included record temperatures, the Skopopelli conference logo modified from the Kokopelli of Native American mythology (Fig. 1), and liberal use of a cattle prod to encourage speaker timeliness.
Design and Synthesis of Peptides That Bind α‐Bungarotoxin with High Affinity and Mimic the Three‐Dimensional Structure of the Binding Site of Acetylcholine Receptor (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Prognostic Value of High-Dose Dobutamine Stress MRI (2011)

IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to making positive contributions to academics, corporate libraries as well as to readers and authors. All the editors in IMR Press will provide the best service for researchers, allowing them to have a easy and smooth publication experience and helping maximize the impact and visibility of their research.
HYPERTONIC SALINE RESUSCITATION AFTER MESENTERIC ISCHEMIA/REPERFUSION INDUCES ILEAL APOPTOSIS VIA CYTOCHROME C PATHWAY (2005)

Departments: Abstracts of Papers Presented at the Thirty-Fifth Annual Scientific Meeting of the Western Trauma Association: PDF Only
On the use of the Muskingum model in real-time sewer network control (2007)

In this paper the use of the Muskingum model as an sewer model for automatic feedback (digital and continuous) control is discussed, taking into account several characteristics (the structure, the effects of the ZOH in the closed-loop and the sampling time). This analysis is carried out by comparison with a virtual reservoir model that is widely used for sewer network control. The results are presented and visualised using a test-bench sewer with a typical geometry.
Discovering the Mutational Profile of Early Colorectal Lesions: A Translational Impact (2021)

Colorectal cancer (CRC) develops through a multi-step process characterized by the acquisition of multiple somatic mutations in oncogenes and tumor-suppressor genes, epigenetic alterations and genomic instability. These events lead to the progression from precancerous lesions to advanced carcinomas. This process requires several years in a sporadic setting, while occurring at an early age and or faster in patients affected by hereditary CRC-predisposing syndromes. Since advanced CRC is largely untreatable or unresponsive to standard or targeted therapies, the endoscopic treatment of colonic lesions remains the most efficient CRC-preventive strategy. In this review, we discuss recent studies that have assessed the genetic alterations in early colorectal lesions in both hereditary and sporadic settings. Establishing the genetic profile of early colorectal lesions is a critical goal in the development of risk-based preventive strategies.
Electromagnetic Wave Manipulation with Metamaterials and Metasurfaces for Future Communication Technologies (2021)

Electromagnetic (EM) waves can be manipulated by varying different physical dimensions of EM waves to realize flexible control over their propagation, radiation, or scattering. EM wave manipulation at various propagation distances can be realized using metamaterials and metasurfaces. The basic building block of metamaterials and metasurfaces is a subwavelength scale meta-atom made of plasmonic or dielectric materials. In a backscattering communication system, the EM backscattering can be intelligently controlled using metamaterials and metasurfaces. In this chapter, we review our recent results of EM wave manipulation at optical frequencies using highly efficient metasurfaces. Although the concepts presented here are related to the optical regime, similar strategies can be used in terahertz or microwave regime by rescaling the geometric dimensions and material parameters appropriately.