gebhart/patrepeval huggingface dataset:
Simultaneous Coding Artifact Reduction and Sharpness Enhancement (2007)

This paper presents an adaptive approach for simultaneous blocking artifact reduction and sharpness enhancement. The proposed method utilizes the local structure information to detect the blocking artifacts and the image edges. Then adaptive filtering is applied to remove the artifacts and sharpen the image detail. In order to obtain the optimal coefficients, we train the adaptive filters offline on a training set, which is composed by original images and the compressed blurred versions of those original images. Experimental results show that the proposed method has great effectiveness in both coding artifacts reduction and sharpness enhancement.
Fluorescent molecular rotors as probes for polymers (1998)

Abstract The use of a molecular rotor (1,1‐dicyano‐4‐(4'‐dimethylaminophenyl)‐1,3‐butadiene) as a fluorescent probe was proved to be of great interest for the study of polymers. First, the rotor can detect the critical time of the glass effect in the bulk polymerization of MMA into PMMA due to viscosity change, this will allow a better control of the process and is complementary to the information issued from the use of the fluorescent pyrene probe which is sensitive to the gel effect. Second, the cinnamylidene rotor was able to detect the formation of hydrophobic microdomains for cationic amphiphilic polymers in their aggregation modes when they were solubilized in water, both polarity and viscosity changes are playing a role. The possibility of incorporation of various molecular fluorescent rotors in polymers beads was also studied.
The Next Steps in Improving the Outcomes of Advanced Ovarian Cancer (2015)

Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication. Second, acquisition of chemotherapy resistance results in untreatable progressive disease. Advances in treatment of advanced ovarian cancer involve a spectrum of interventions including improvements in frontline debulking surgery and combination chemotherapy. Anti-angiogenic factors have been shown to have activity in frontline and recurrent disease while novel chemotherapeutic agents and targeted treatments are in development particularly for disease that is resistant to platinum-based chemotherapy. These developments aim to improve the progression-free and overall survival of women with advanced ovarian cancer.
Microlens formation by thin-film deposition with mesh-shaped masks (1999)

Thin-film microlens arrays with high fill factors have been fabricated in a one-step process by shading a vapor beam in a vacuum-deposition apparatus with metallic meshes placed at defined distances to the substrate surface. To generate three-dimensional mask structures with the necessary depth profiles, microgalvanic technology has been applied. Profiles and optical properties of the microlenses have been studied theoretically and experimentally.
Vorstellung des neugegründeten krankheitsbezogenen Kompetenznetz Multiple Sklerose (2009)

Im Rahmen der Etablierung des BMBF-geförderten krankheitsbezogenen Kompetenznetzes für Multiple Sklerose (KKNMS) werden drei Verbundanträge gefördert. Die drei Verbünde befassen sich mit grundlagenorientierter Pathogeneseforschung (UNDERSTANDMS), Diagnose- und Therapieforschung (CONTROLMS) und einem epidemiologischen Registeransatz für kindliche MS (CHILDRENMS). Das KKNMS setzt sich aus den geförderten Verbünden und einer verbundübergreifenden Leitungsstruktur zusammen.
Network Economy (2001)

ZusammenfassungDie 90er Jahre waren geprägt durch die Digitalisierung von Gütern und Abläufen, die in Verbindung mit einer rasanten Verbreitung von elektronischen Netzen zu strukturellen Umbrüchen in Wirtschaft und Gesellschaft geführt haben (Hofmann 2001, S. 1). Es zeichnen sich vollkommen neuartige Strukturen ab, die hier als Network Economy bezeichnet werden sollen und die ein Umdenken auf Seiten von Unternehmen und Kunden erforderlich machen.
AlSi7 metallic foams – aspects of material modelling for crash analysis (2009)

Metallic foam samples of matrix alloy AlSi7 have been produced and mechanically tested under quasi-static and dynamic load. Model parameters for the Deshpande-Fleck and the ABAQUS 'crushable foam' material model were determined covering a density of 0.3-0.8 g/cm3. Yield surface determination uses uniaxial hydrostatic compression test results, extended by tensile test results for the latter model. Strain hardening was described on the basis of uniaxial compression by fitting a Rusch model to the experimental data, deriving its parameters as function of density. The predictive capabilities of the parameterised models were evaluated using experimental data gathered for load cases characterised by superimposed uniaxial and hydrostatic compression. Analyses show good agreement between simulation and experiment. Further uniaxial compression tests performed at varying strain rates over 4 orders of magnitude revealed no significant strain rate dependency of material properties and thus qualify the material model parameters determined for crash simulation.
ChemInform Abstract: Recent Advances in Direct C—H Arylation: Methodology, Selectivity and Mechanism in Oxazole Series (2012)

Abstract Review: 84 refs.
Relationship between IFN-gamma and skin test responsiveness to Mycobacterium tuberculosis PPD in healthy, non-BCG-vaccinated young adults in Northern Malawi. (2001)

The 6 day IFN-gamma response to PPD correlates well with Mantoux skin test induration. The discordant individuals may represent important subsets in terms of protective immunity and risk of clinical tuberculosis.
DEVELOPMENT OF HIGH-EFFICIENCY AbtCao.sAs SOLAR CELLS AND INTERCONNECT SCHEMES FOR Alo~zGao~sAs/Si MECHANICALLY-STACKED CASCADE CELLS (1993)

Alo,,G%.,As/Si mechanically-stacked cascade cells offer potential AM0 power conversion efficiencies > 25 percent. The demonstration of a high-performance stack requires three critical components, a high efficiency (i 18 percent) Alo~2Gao,,As top cell, a high-conductance interconnect, and a high-efficiency Si bottom cell. In this work, we present the development of a 17 percent (active-area) efficient p+-n Al,,G%,,As solar cell. The cell has a V,, of 1.22 V, a J, of 21.8 mA/cm2 , and a fill-factor of 0.865. The Alo,2$,8As cells were grown by low-pressure organometallic vapor phase epitaxy. The introduction of an undoped spacer layer between the n-base and the p+- emitter is found to improve the fillfactor and the red response of the cells. Second, we report an interconnect scheme for the mechanical stacking of the AlGaAs cells onto a Si substrate. The technique involves an eutectic-metal-bond (Em) using a Au/Sn/Au metallization between GaAs (contact layer to the base of the AlGaAs cell) and Si. Preliminary evaluation of this EME! interconnect reveals a resistivity of z 4.2 x ohm-cm2 which is adequate for AM0 operation. The advantages of this interconnect for the p+-n cell configuration, including suitability in a manufacturing environment for the production of low-cost AlGaAs/Si mechanically-stacked cells, are presented.
Skill representation and acquisition of compliant motions using a teach device (2002)

We are proposing a supervised learning approach in robot force control which enables robot programming by human demonstration. To demonstrate the task in an intuitive way, we designed a teach device which acquires the sensorimotion of the human. The design and use of the teaching device for skill acquisition is discussed. Recording of compliant motion, of the human is shown for the "put block in a corner of a box problem" and the "peg in hole problem". Skill representation is demonstrated for the first of the two problems. Finally we are describing other useful applications of the teach device in the field of world modeling and robotics.
Amorphous‐oxide TFT backplane for large‐sized AMOLED TVs (2011)

Abstract— Amorphous‐oxide thin‐film‐transistor (TFT) arrays have been developed as TFT backplanes for large‐sized active‐matrix organic light‐emitting‐diode (AMOLED) displays. An amorphous‐IGZO (indium gallium zinc oxide) bottom‐gate TFT with an etch‐stop layer (ESL) delivered excel lent electrical performance with a field‐effect mobility of 21 cm 2 /V‐sec, an on/off ratio of &gt;10 8 , and a subthreshold slope (SS) of 0.29 V/dec. Also, a new pixel circuit for AMOLED displays based on amorphous‐oxide semiconductor TFTs is proposed. The circuit consists of four switching TFTs and one driving TFT. The circuit simulation results showed that the new pixel circuit has better performance than conventional threshold‐voltage (V TH ) compensation pixel circuits, especially in the negative state. A full‐color 19‐in. AMOLED display with the new pixel circuit was fabricated, and the pixel circuit operation was verified in a 19‐in. AMOLED display. The AMOLED display with a‐IGZO TFT array is promising for large‐sized TV because a‐IGZO TFTs can provide a large‐sized backplane with excellent uniformity and device reliability.
Impact of Serial Scaling of Multi-threaded Programs in Many-Core Era (2014)

Estimating the potential performance of parallel applications on the yet-to-be-designed future many cores is very speculative. The traditional laws used to predict performance of an application do not reflect on the various scaling behaviour of a multi-threaded (MT) application leading to optimistic estimation of performance in many core era. In this paper, we study the scaling behavior of MT applications as a function of input workload size and the number of cores. For some MT applications in the benchmark suites we analysed, our study shows that the serial fraction in the program increases with input workload size and can be a scalability-limiting factor. Similar to previous studies [5], we find that using a powerful core (heterogeneous architecture) to execute this serial part of the program can mitigate the impact of serial scaling and improve the overall performance of an application in many-core era.
Cleavage mediated by the P15 domain of bacterial RNase P RNA (2011)

Independently folded domains in RNAs frequently adopt identical tertiary structures regardless of whether they are in isolation or are part of larger RNA molecules. This is exemplified by the P15 domain in the RNA subunit (RPR) of the universally conserved endoribonuclease P, which is involved in the processing of tRNA precursors. One of its domains, encompassing the P15 loop, binds to the 3'-end of tRNA precursors resulting in the formation of the RCCA-RNase P RNA interaction (interacting residues underlined) in the bacterial RPR-substrate complex. The function of this interaction was hypothesized to anchor the substrate, expose the cleavage site and result in re-coordination of Mg(2+) at the cleavage site. Here we show that small model-RNA molecules (~30 nt) carrying the P15-loop mediated cleavage at the canonical RNase P cleavage site with significantly reduced rates compared to cleavage with full-size RPR. These data provide further experimental evidence for our model that the P15 domain contributes to both substrate binding and catalysis. Our data raises intriguing evolutionary possibilities for 'RNA-mediated' cleavage of RNA.
초현실주의 패션디자인 개발과 디지털 미디어 융합 전시 연구 (2013)

본 연구의 목적은 20세기를 대표하는 진보적 영역인 초현실주의 패션을 디자인하고, 디자인과 디지털 매체를 결합시킨 전시 공간 연출을 통하여 초현실주의 패션의 범위를 더욱 광범위하게 표현하고자 하였다. 초현실주의 패션은 디지털 매체 기술 발달을 통해 더 무한해진 영역의 사고와 상상력으로 표현되고 있으며, 이는 물질성의 전통적 패션과는 확연히 구분되는 패러다임을 가진다. 초현실주의의 무의식과 의식의 융합을 컨셉으로 디지털 텍스타일 프린트와 디지털 매체의 비물질성 공간을 융합하여 초현실주의 패션 디자인으로 표현하고자 하였다. 초현실주의의 무의식 속 빛의 색을 패턴으로 디자인하여 메쉬, 스팽글(spangle) 원단, 코튼 등 다양한 소재에 DTP(Digital Textile Print)를 적용하였다. 디자인에 있어서 블랙과 명시성 높은 컬러의 패턴은 초현실주의 속 실재와 무의식이 모여 경계를 허물려는 의도가 반영된 것이다. 또한 비대칭성과 조형성을 강조하여 착장자에 따라 입는 방식의 다양한 변형을 가능하게 하여 개성있는 착용자의 확대와 대중성을 가질 수 있게 하였다. 이러한 초현실주의 패션 디자인과 디지털 매체의 융합은 현실의 전시 공간에 미디어 환경을 제공하는 방식을 사용하였으며, 전시공간에서 단순한 영상의 제시가 아닌 전시에 초현실적 공간적 개념을 도입한 것이다. 전시되는 옷은 디지털 매체와 함께 상황, 공간의 경계를 모호하게 하고 가상 상황을 연출하는 매개체의 역할을 하며, 전시공간의 개념 또한 디자인의 일부로 융합되었다.
Calcium Chelation of Lignin from Pulping Spent Liquor for Water-Resistant Slow-Release Urea Fertilizer Systems (2016)

Slow-release fertilizers represent a possible large-scale application for plant polymers. Here we show a facile way to stabilize urea in fertilizer systems by lignin. Chelation of kraft black liquor with calcium acetate at pH 13 precipitated lignin as a calcium complex (Ca-lignin), which offered beneficial effects if compared to those from lignin obtained by precipitation at low pH (Acid-lignin). The reduced affinity of water to Ca-lignin was exploited in the formulation of slow-release fertilizers comprising wheat straw sections impregnated with Ca-lignin in molten urea. Compared to the case of Acid-lignin, immersion in water was slowed down more extensively by Ca-lignin. After 24 h incubation at low moisture conditions, the highest proportion of urea retained in the Ca-lignin/straw fertilizer system was 58%. The water resistance of Ca-lignin was explained by a lower aqueous solubility that differed from the typical pH-dependent solubility of Acid-lignin. Electron microscopy, infrared spectroscopy, and accessible surface areas suggested that Ca-lignin consisted of less densely packed molecules organized as calcium-chelated chains. Overall, the controlled water-solubility of lignin precipitated by metal cations is greatly beneficial in fertilizer systems and can open new opportunities in material development (permeable films and others).
LED-based photoacoustic imaging for early detection of joint inflammation in rodents: towards achieving 3Rs in rheumatoid arthritis research (2020)

Synovial angiogenesis and hypoxia in the joints are biomarkers of Rheumatoid Arthritis (RA). The ability to probe blood and accurately estimate the oxygen concentration make multiwavelength Photoacoustic (PA) imaging a potential tool for early detection of RA. In this work, a multiwavelength LED-based PA imaging system was characterized based on its imaging depth, resolution and accuracy of oxygen saturation estimation. A multicenter 3R (Replace, Refine and Reduce) focused small animal study was conducted. The 3R strategy was devised by reusing RA animal models, in vivo imaging of healthy animals and ex vivo studies with human blood. RA animal cadaver models with different levels of synovial angiogenesis (control, positive RA and treated) were imaged and compared against results from a previous study using the same samples. An ex vivo PA oxygen saturation imaging using human blood was validated against oximeter readings and further verified it with in vivo animal studies. An imaging depth of 8 mm with an SNR of 10 dB was achieved for RA samples. A difference in PA intensity was observed for RA models compared to control and treated group. The PA oxygen saturation estimation correlates with oximeter readings, which is confirmed with in vivo studies. The results show the efficacy of the LED-based PA imaging system in RA diagnosis based on synovial angiogenesis and hypoxia. The imaging depth, resolution and oxygen saturation estimate are sufficient to differentiate RA samples from control. Our future work will focus on validating the method using arthritis animal models and demonstrating the 3R potential.
<title>Optical neuron network based on a x<formula><sup><roman>(2)</roman></sup></formula> hologram recording</title> (1996)

Recording of dynamic nonlinear (chi) <SUP>(2</SUP>) hologram in glasses, based on the effect of photoinduced second harmonic generation is considered. Application of this phenomenon to generate a matrix of neurons for optical neuron network (NN) is proposed and studied by computer simulation. In the proposed model of NN a main laser radiation serves as a pump, and its second harmonic carries a signal. Modulation of the signal is achieved by both changing the signal amplitude and changing the relative phase between the signal and the pump. Computer simulation demonstrated that application of (chi) <SUP>(2</SUP>) hologram recording to create optical NN is possible. Also it was determined a structure of feedback in a NN that is able to the fast pattern recognition and can act as an associative memory.
Teaching Reform of "Engineering Drawing" under Background of the "New Engineering" (2019)

The construction of "New Engineering" puts forward new requirements for teaching methods. Therefore, it is necessary to adopt effective teaching methods to realize the cultivation of students' innovative ability. Under the background of the "New Engineering", the teaching methods reform of "Engineering Drawing" based on micro-class and flip classroom is important. It mainly realizes the educational concept of comprehensive and coordinated development of knowledge, ability and quality of students. It cultivates students' engineering practice ability and design ability. It effectively solves the problems of "engineering" and "innovation", ensuring that students are targeted in the process of learning. The teaching methods reform practice results show the studentsâ€™ practical ability and problem-solving ability are improved, and the learning ability and awareness of communication between each other are enhanced. The teaching methods stimulate students' learning interest and enthusiasm, and effectively improving the teaching quality of the "Engineering Drawing".
The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro (2003)

These data suggest that FTS might be a useful agent against PCa that has relapsed after ADT.
Pharmaceutical Emulsions (2013)

Pharmaceutical Emulsions: A Drug Developer's Toolbag covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for its application. The author uses his extensive experience in both industry and academic experience to provide a concise, student friendly guide to the essential fundamentals of physical pharmacy. Divided into three clear sections, the text begins with Section A - Consideration for Product: Medicinal Formulation which includes a historical perspective, explanation of what is an emulsion, stability and instability, and manufacture. Section B - Forms, Use and Application follows, with chapters on creams and ointments, pastes and bases, colloids, transdermal, gels and implants. The final Section, Tests: Chemistry to control the quality, efficacy and fitness for purpose of the product includes chapters on physic-chemical properties, sizing and microscopy, rheology, QC and finally questions, calculations and dilemmas. Throughout the text there are numerous figures, diagrams and tables to engage the reader. This is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms as well as industry professionals.
Supplementary Figure 4 from First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;Supplementary Figure 4. Association between severity of treatment-related rash and steady-state exposure (day 15 AUC0-24) to pictilisib. (Gr=Grade).&lt;/p&gt;
Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans. (1985)

In this report, we describe our findings on the relationship between estradiol 16 alpha-hydroxylation and mammary tumor incidence. A close correlation between the two has been demonstrated with 16-hydroxylation being elevated in strains with a high incidence of tumors, such as RIII and C3H, and low in strains with a low incidence of cancer, such as C57BL. The extent of reaction is highly reproducible and unaffected by age or presence of overt mammary tumors. Studies on the inheritance of estradiol 16 alpha-hydroxylase showed that it is inherited as an autosomal dominant and is not correlated with estradiol 2-hydroxylase or androgen and progestin 16 alpha-hydroxylases. In addition, the reaction was shown to be markedly enhanced by the presence of murine mammary tumor virus and diminished in the absence of the virus. These studies establish a relationship between genetics, hormonal factors, and murine mammary tumor virus, the three key factors in mammary tumorigenesis.
Effect of In-band Intermodulation Interference on Direct-Sequence Spread Spectrum (DSSS) Communication Systems for Electromagnetically Diverse Applications (2007)

The goal of this paper is to analyze the effect of nonlinearities on the performance of direct-sequence spread spectrum systems in the context of electromagnetically diverse applications. Inter-modulation products due to nonlinear amplification are analyzed and the effect of nonlinearities is illustrated by means of a computer simulation result. For the performance measure, bit-error rate (BER) is considered to assess the effect of in-band intermodulation interference. The findings of this study will be of benefit to the waveform diversity community. This community concerned with assessing the effects of multiple RF sensor and communication systems used for enhancing cooperative target tracking and engagement. This involves multiple radars and communication systems that process acquired information in real time. The optimum performance, operation and availability of these systems are assured through the application of adaptive spread spectrum waveforms and electromagnetic diversity schemes derived for the RF communications problem.
Activity-dependent modulation of axonal excitability is modality specific in cutaneous afferents (1990)

Advances in plastic surgery require that consultation psychiatry respond with increasing sophistication. Self-mutilating patients may now undergo genital reimplantation, but few guidelines exist for their psychiatric management. We describe three contrasting cases of male genital self-mutilation, demonstrating the differential impact of psychiatric consultation, and offer guidelines for a consultative strategy to the surgical team, patient, and family. A general management plan for consulting psychiatrists is presented.
Solution steering with space-variant filters (2007)

Most geophysical problem require some type of regularization. Unfortunately most regularization schemes produce &amp;quot;smeared&amp;quot; results that are often undesirable when applying other criteria (such as geologic feasibility). By forming regularization operators in terms of recursive steering filters, built from a priori information sources, we can efficiently guide the solution towards a more appealing form. The steering methodology proves effective in interpolating low frequency functions, such as velocity, but performs poorly when encountering multiple dips and high frequency data. Preliminary results using steering filters for regularization in tomography problems are encouraging.
Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells (2001)

Whereas classical beta-blockers do not affect cell growth, only nebivolol inhibits haCSMC or haEC proliferation and induces a moderate rate of apoptosis. Furthermore, in HaCEs NO formation increases and endothelin-1 secretion decreases suggesting that nebivolol may represent a beta-blocker with great promises in CAD therapy.
Genetic Algorithm: Application to Scattered Data Problems using Lipschitz Interpolation (2008)

In this paper, a low computational method of efficiently and quickly handling large multivariate scattered data sets with a genetic algorithm for design parameter optimization is presented. The method presented combines the use of a genetic algorithm and the linear interpolation technique identified as Lipschitz Interpolation. Using this method we have improved the performance of the algorithm in two ways, the variance of the solution and the total algorithm evaluation time (an improvement of magnitude 90%).