gebhart/patrepeval huggingface dataset:
Supplementary Table S6 from Immunotherapy with a HER2-Targeting <i>Listeria</i> Induces HER2-Specific Immunity and Demonstrates Potential Therapeutic Effects in a Phase I Trial in Canine Osteosarcoma (2023)

&lt;p&gt;Necropsy findings including location of metastatic lesions, tumor type and subtype, tumor grade and HER2/neu status in ADXS31-164 treated dogs.&lt;/p&gt;
Advantages and limitations of noninvasive devices for cardiac output monitoring: a literature review (2023)

Noninvasive cardiac output monitoring may have a clinical impact on patient outcomes. Further studies are required to evaluate their clinical relevance, notably in the intensive care unit. Noninvasive monitoring opens up the possibility for hemodynamic optimization in specific or low-risk populations, the benefit of which remains to be assessed.
Employment mode choices in early and late stage start ups : a preliminary exploration using fsQCA (2012)

Startup organizations are faced with the need to mature along the dimensions of intentionality, resources, boundary and exchange (Katz & Gartner, 1988). Lacking any one of these four dimensions places restraints on the Human Resource management options available to these firms. Specifically, the authors offer a predictive theory of employment mode (hire, develop, contract, or strategic alliance) based on a firm’s levels of intentionality, resources, boundary and exchange. Fuzzy Set Qualitative Comparative Analysis (fsQCA) is used to test hypotheses based on the theory. Preliminary evidence indicates that levels of intentionality, resources, boundary and exchange may affect employment mode decisions in startup organizations that are in the Construction, Manufacturing, and Transportation industries.
Bulk‐Plasmon‐Mediated Free‐Electron Radiation Beyond the Conventional Formation Time (2023)

Free-electron radiation is a fundamental photon emission process that is induced by fast-moving electrons interacting with optical media. Historically, it has been understood that, just like any other photon emission process, free-electron radiation must be constrained within a finite time interval known as the "formation time," whose concept is applicable to both Cherenkov radiation and transition radiation, the two basic mechanisms describing radiation from a bulk medium and from an interface, respectively. Here, this work reveals an alternative mechanism of free-electron radiation far beyond the previously defined formation time. It occurs when a fast electron crosses the interface between vacuum and a plasmonic medium supporting bulk plasmons. While emitted continuously from the crossing point on the interface-thus consistent with the features of transition radiation-the extra radiation beyond the conventional formation time is supported by a long tail of bulk plasmons following the electron's trajectory deep into the plasmonic medium. Such a plasmonic tail mixes surface and bulk effects, and provides a sustained channel for electron-interface interaction. These results also settle the historical debate in Ferrell radiation, regarding whether it is a surface or bulk effect, from transition radiation or plasmonic oscillation.
Human Pancreatic Duct Cells Exert Tissue Factor-Dependent Procoagulant Activity (2004)

Activation of the coagulation cascade contributes to early graft loss and intraportal thrombotic events in clinical islet transplantation. Although these complications were shown to be related to the presence of tissue factor in human islet preparations, the contribution of duct cells, which represent a major contaminant of clinical islet isolates, has not been specified so far. Herein, we used flow cytometry, immunohistochemistry, RT-PCR, and functional coagulation assays to demonstrate that duct cells exert a potent factor VII-dependent procoagulant activity related to their expression of tissue factor. Both the classical membrane-bound and the recently described soluble form of tissue factor were shown to be synthesized by duct cells. We conclude that contaminating duct cells contribute to early β-cell damage after islet transplantation through their involvement in tissue factor-mediated thrombotic and inflammatory events.
Solubilization and functional reconstitution of the protein-translocation enzymes of Escherichia coli. (1990)

The SecY protein and other membrane proteins of Escherichia coli were solubilized by mixed micelles of n-octyl beta-D-glucopyranoside, phospholipids, and glycerol. Proteoliposomes formed from this extract by detergent dialysis supported energy-dependent translocation and processing of pro-OmpA. Translocation required ATP, SecY, and SecA and was stimulated by a proton-motive force. These results provide an important assay for the isolation and identification of membrane components involved in protein translocation.
ChemInform Abstract: A POLYAMIDE SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS (1977)

Abstract Die Festphasensynthese von Oligodesoxyribonucleotiden wie (I) und (II) gelingt in guten Ausbeuten unter Verwendung von vernetztem Polydimethylacrylamidharz als Träger [geschätzter molarer Gesamtumsatz im Falle von (I), bezogen auf polymergebundenes dpT, 43%; Gesamtumsatz bei (II), bezogen auf polymergebundenes dpC, 20%].
Efficient support of concurrent threads in a hybrid dataflow/von Neumann architecture (2002)

Examines the thread support in a multi-threaded processor architecture, called the Super-Actor Machine (SAM). The SAM employs a novel organization of high-speed buffer memory known as the register-cache-a memory device organized both as a register file and a cache, and is used as a buffer between the execution unit and main memory. To characterize the floating-point performance of the machine on scientific benchmarks, a new performance measure is introduced, called the Floating-point Arithmetic and logic operations per machine Beat, or FAB for short. Results from a detailed simulation are very encouraging: for the memory-intensive SAXPY scientific loop, a processing element of the SAM can attain a .85 FAB rating as compared to a value of nearly 1 for the IBM RS/6000 which employs the combined floating-point add-multiply operation (this type of instruction has not been implemented on the SAM yet). Furthermore, the SAM can attain this rating with less execution resources (i.e. high-speed registers) than typical multi-threaded architectures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Spectrophotometric Evidence of Polymerization in Peroxytitanic Acid Solutions (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric Evidence of Polymerization in Peroxytitanic Acid SolutionsRichard E. Reeves and Hans B. JonassenCite this: J. Am. Chem. Soc. 1954, 76, 21, 5354–5356Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01650a030https://doi.org/10.1021/ja01650a030research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy in Patients With Rectal Cancer (2019)

The study does not support that statin use is associated with response to neoadjuvant chemoradiotherapy in terms of disease-free survival, recurrence-free survival or all-cause mortality.
The role of oxidative stress in EBV lytic reactivation, radioresistance and the potential preventive and therapeutic implications (2017)

Epstein-Barr virus (EBV) is an important cancer causing virus. Cancer associated with EBV account for approximately 1.5% of all cancers, and represent 1.8% of all cancer deaths worldwide. EBV reactivation plays an important role in the development of EBV-related diseases and is closely related with patients' survival and clinical stages of EBV-related cancers. The therapy regarding to EBV-related cancers is very urgent, especially in endemic areas. Generating oxidative stress is a critical mechanism by which host cells defend against infection by virus. In addition, ROS-mediated oxidative stress plays a significant but paradoxical role acting as a "double-edged sword" to regulate cellular response to radiation, which is the main therapy strategy for EBV-related cancers, especially nasopharyngeal carcinoma. Therefore, in this review we primarily discuss the possible interplay among the oxidative stress, EBV lytic reactivation and radioresistance. Understanding the role of oxidative stress in EBV lytic reactivation and radioresistance will assist in the development of effective strategies for prevention and treatment of EBV-related cancers.
Refractive error, axial length, environmental and hereditary factors associated with myopia in Swedish children (2021)

<b>Clinical relevance</b>: Investigation of refractive errors amongst Swedish schoolchildren will help identify risk factors associated with myopia development.<b>Background</b>: Genetic and hereditary aspects have been linked with the development of myopia. Nevertheless, in the case of 'school myopia' some authors suggest that environmental factors may affect gene expression, causing school myopia to soar. Additional understanding about which environmental factors play a relevant role can be gained by studying refractive errors in countries like Sweden, where prevalence of myopia is expected to be low.<b>Methods</b>: Swedish schoolchildren aged 8-16 years were invited to participate. Participants underwent an eye examination, including cycloplegic refraction and axial length (AL) measurements. Predictors such as time spent in near work, outdoor activities and parental myopia were obtained using a questionnaire. Myopia was defined as spherical equivalent refraction (SER) ≤ -0.50D and hyperopia as SER ≥ +0.75D.<b>Results</b>: A total of 128 children (70 females and 58 males) participated in this study with mean age of 12.0 years (SD = 2.4). Based on cycloplegic SER of the right eye, the distribution of refractive errors was: hyperopia 48.0% (CI95 = 38.8-56.7), emmetropia 42.0% (CI95 = 33.5-51.2) and myopia 10.0%. (CI95 = 4.4-14.9). The mean AL was 23.1 mm (SD = 0.86), there was a correlation between SER and AL, r = -0.65 (p < 0.001). Participants with two myopic parents had higher myopia and increased axial length than those with one or no myopic parents. The mean time spent in near work, outside of school, was 5.3 hours-per-day (SD = 3.1), and mean outdoor time reported was 2.6 hours-per-day (SD = 2.2) for all the participants. The time spent in near work and outdoor time were different for different refractive error categories.<b>Conclusion</b>: The prevalence of myopia amongst Swedish schoolchildren is low. Hereditary and environmental factors are associated with refractive error categories. Further studies with this sample are warranted to investigate how refractive errors and environmental factors interact over time.
A 5-band Temporal Lifting Scheme for Video Surveillance (2006)

Three-dimensional (3D) wavelet coding schemes compression applications. The scalability property of such schemes is one of the most important issues for video surveillance systems. In this paper we introduce a new lifting-based method of temporal decomposition which provides a scalability factor of 5 in a motion-compensated subband video coding scheme. Depending on the sequence characteristics, motion model etc., this structure can provide high coding performance. Also, it gives a better leading to an improved temporal scalability. It addresses video surveillance applications, where the motion is very low in most cases
Differential Susceptibility to a Viral Agent in Mice Housed Alone or in Groups (1970)

In two strains of mice, individually housed animals were more susceptible to encephalomyocarditis (EMC) virus than those housed in groups. Increasing the size of the group from 5 to 20 mice/cage did not further alter resistance. Attempts were made to delineate the physiologic mechanism(s) responsible for the differential susceptibility to EMC virus. Body weight and body temperature prior to injection did not differ in individually and group-housed mice. Interferon and antibody levels following inoculation with EMC virus did not explain the observed differences in mortality, nor did the antibody levels observed in response to an inactivated EMC virus vaccine. Corticosterone levels at the peak of the adrenocortical rhythm were noted to be higher in mice housed individually than in those housed 5/cage, and this difference was noted both prior to and following EMC inoculation.
The mucosal and systemic immune responses elicited by a chitosan‐adjuvanted intranasal influenza H5N1 vaccine (2011)

The cross-clade serum reactivity, improved B- and T-cell responses and dose-sparing potential of chitosan show that a chitosan-adjuvanted intranasal influenza vaccine is a promising candidate vaccine for further preclinical development.
FIR-median hybrid filters (1987)

This paper introduces a new generalized class of median-type filters which we call FIR-median hybrid (FMH) filters. The input signal x(n) is filtered with M linear phase FIR filters, and the output of the FMH filter is the median of the outputs of the FIR filters. The statistical properties of the FMH filters are analyzed for input signals with Gaussian, double exponential, and uniform density functions. It is shown that FMH filters have essentially the same statistical properties and same type of root signals as the standard median (SM) filters. FMH filters preserve corner points and ramps and attenuate impulsive-type noise components effectively. An interesting subclass of the FMH filters requiring only one scaling multiplier, two additions, and three compare/swap operations irrespective of the filter length is introduced. In the examples, speed improvement by a factor of 450 is obtained over an otherwise approximately equivalent SM filter.
Enantioselective Copper‐Catalyzed Decarboxylative Propargylic Alkylation of Propargyl β‐Ketoesters with a Chiral Ketimine P,N,N‐Ligand (2013)

The first enantioselective copper-catalyzed decarboxylative propargylic alkylation has been developed. Treatment of propargyl β-ketoesters with a catalyst, prepared in situ from [Cu(CH3 CN)4 BF4 ] and a newly developed chiral tridentate ketimine P,N,N-ligand under mild reaction conditions, generates β-ethynyl ketones in good yields and with high enantioselectivities without requiring the pregeneration of ketone enolates. This new process provides facile access to a range of chiral β-ethynyl ketones in a highly enantioenriched form.
Virtual worlds using computer vision (2002)

Virtual Reality has traditionally relied on hand-created synthetic virtual worlds as approximations of real world spaces. Creation of such virtual worlds is very labour intensive. Computer vision has recently contributed greatly to the creation of the visual/graphical aspect of the virtual worlds. These techniques are classified under image-based-as opposed to geometry-based-rendering in computer graphics. Image based rendering (IBR) aims to recreate a visual world given a few real views of it. We survey some of the important image-based rendering techniques in this paper, analyzing their assumptions and limitations. We then discuss Virtualized Reality, our contribution to the creation of virtual worlds from dynamic events using a stereo technique that gives dense depth maps on all-around views of the event. The virtualized world can be represented as multiple view-dependent models or as a single view-independent model. It can then be synthesized visually given the position and properties of any virtual camera. We present a few results from 3D Dome, our virtualizing facility.
Unique Structure and Stability of HmuY, a Novel Heme-Binding Protein of Porphyromonas gingivalis (2009)

Infection, survival, and proliferation of pathogenic bacteria in humans depend on their capacity to impair host responses and acquire nutrients in a hostile environment. Among such nutrients is heme, a co-factor for oxygen storage, electron transport, photosynthesis, and redox biochemistry, which is indispensable for life. Porphyromonas gingivalis is the major human bacterial pathogen responsible for severe periodontitis. It recruits heme through HmuY, which sequesters heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR. Here we report that heme binding does not significantly affect the secondary structure of HmuY. The crystal structure of heme-bound HmuY reveals a new all-beta fold mimicking a right hand. The thumb and fingers pinch heme iron through two apical histidine residues, giving rise to highly symmetric octahedral iron co-ordination. The tetrameric quaternary arrangement of the protein found in the crystal structure is consistent with experiments in solution. It shows that thumbs and fingertips, and, by extension, the bound heme groups, are shielded from competing heme-binding proteins from the host. This may also facilitate heme transport to HmuR for internalization. HmuY, both in its apo- and in its heme-bound forms, is resistant to proteolytic digestion by trypsin and the major secreted proteases of P. gingivalis, gingipains K and R. It is also stable against thermal and chemical denaturation. In conclusion, these studies reveal novel molecular properties of HmuY that are consistent with its role as a putative virulence factor during bacterial infection.
Prolonged Analgesia After Epidural Injection of a Poorly Soluble Salt of Fentanyl (1994)

Epidurally administered fentanyl is commonly used in postoperative pain management. The onset of action is rapid, but the duration of analgesia is short. In this study we examined the hypothesis that a poorly soluble salt of fentanyl (fentanyl pamoate) would create a depot of the drug in the epidural space and thus provide prolonged analgesia. The dose-response relationship and duration of analgesic action of epidural fentanyl citrate (FC) and fentanyl pamoate (FP) were studied in white male Sprague-Dawley rats. Somatic and visceral nociceptive stimulation (tail flick and colorectal distension, respectively) were used to test the analgesic effects of the drugs. The calculated dose producing 100% of the maximum possible effect (100% MPE) for FP was 31 micrograms toward somatic and 33 micrograms toward visceral noxious stimulation, and for FC it was 3 micrograms toward both stimulations. The antinociceptive effects were similar, with 31 micrograms of FP and 3 micrograms of FC. The areas under the time-response curves (AUC) were significantly higher with FP than with FC when high doses (5 micrograms of FC or 50 micrograms of FP) were used, but with doses expected to produce 100% MPE, differences between the study drugs were not observed in the duration of analgesia. We conclude that the duration of antinociceptive effect of fentanyl can be prolonged when administered as a poorly soluble salt.
Convex Optimization for Spring Design in Series Elastic Actuators: From Theory to Practice (2021)

Natural dynamics, nonlinear optimization, and, more recently, convex optimization are available methods for stiffness design of energy-efficient series elastic actuators. Natural dynamics and general nonlinear optimization only work for a limited set of load kinetics and kinematics, cannot guarantee convergence to a global optimum, or depend on initial conditions to the numerical solver. Convex programs alleviate these limitations and allow a global solution in polynomial time, which is useful when the space of optimization variables grows (e.g., when designing optimal nonlinear springs or co-designing spring, controller, and reference trajectories). Our previous work introduced the stiffness design of series elastic actuators via convex optimization when the transmission dynamics are negligible, which is an assumption that applies mostly in theory or when the actuator uses a direct or quasi-direct drive. In this work, we extend our analysis to include friction at the transmission. Coulomb friction at the transmission results in a non-convex expression for the energy dissipated as heat, but we illustrate a convex approximation for stiffness design. We experimentally validated our framework using a series elastic actuator with specifications similar to the knee joint of the Open Source Leg, an open-source robotic knee-ankle prosthesis.
Development of an image data acquisition system using a multi-function front camera for automotive applications (2015)

This paper presents the development of an image data acquisition system that uses a multi-function front camera in automotive applications. The multi-function front camera detects lanes, vehicles, traffic signals, objects, and pedestrians, and the system signals the driver about these obstacles. The image data acquisition system stores and synchronizes both the recognition results and the vehicular information.
A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein (1994)

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan-transport defect in kes1 delta or osh1 delta mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.
<title>Multiperspective look-around autostereoscopic projection display using an ICFLCD</title> (1999)

DTI has demonstrated a laboratory model of a multiple zone autostereoscopic display with look around capability and a 21' diagonal screen. The display exploits the extremely fast address rates and liquid crystal response speeds associated with ICFLCDs to generate eight to twenty four images during the 1/60th second that a single image is usually displayed. These images consists of the three color components of eight different perspective views of a scene. Optics are used to magnify the images and project them onto a special lens and diffuser screen, which in turn directs light from each image into a different viewing zone in front of the display. Since the perspective views are time multiplexed, each possesses the full resolution of the ICFLCD. An advanced method of generating gray scale using the digital ICFLCD in combination with a time varying light source was also demonstrated. For the most part, off the shelf components were used to construct the key elements of the system including the projection screen and the precision magnifying optics, promising easy commercialization and low production cost. The display is being developed into a prototype, to be followed by production of 1024 X 768 or 1280 X 1024 desktop rear projection display for workstation applications.