gebhart/patrepeval huggingface dataset:
Mansonella perstans: safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination (2009)

The safety and efficacy of a single dose of ivermectin alone (150-200 microg/kg bodyweight), albendazole alone (400 mg) or the combination of these two drugs was assessed, in Uganda, in three groups of individuals infected with Mansonella perstans (with 15, 13 and 15 subjects in each group, respectively). No side-effects were observed or reported during the first 7 days post-treatment and every subject remained microfilaraemic during the 12 months of follow-up. In the subjects given ivermectin alone or albendazole alone, the microfilarial intensities consistently remained close to their pre-treatment levels. In the subjects given both drugs, however, the microfilarial intensities decreased slightly after treatment and at 1 and 3 months post-treatment (but not at 6, 9 or 12 months) they were significantly lower than in the two other groups combined. The three single-dose drug regimens investigated were thus well tolerated but had disappointingly low efficacies in the treatment of M. perstans microfilaraemias.
Effect of Immunotherapy on Seasonal Changes in Serum‐Specific IgE and IgG4 in Patients With Pollen Allergic Rhinitis (1997)

Serum specific IgE and IgG4 in 70 patients with seasonal rhinitis caused by Japanese cedar pollens were determined before and during the pollen season. Seasonal increase rate in specific IgE was significantly smaller in the immunotherapy patients than the pharmacotherapy patients, and seasonal increase in specific IgG4 was significant in the immunotherapy patients only. Seasonal increase rate in specific IgE was not significantly different between the patients who responded markedly to short-term immunotherapy and those who did not. On the other hand, seasonal increase rate in specific IgG4 was significantly different between them. In contrast, seasonal increase rate in specific IgE was significantly smaller in the patients who showed marked response to the long-term immunotherapy than those who did not show marked response to the long-term immunotherapy, but seasonal increase rate in specific IgG4 was not significantly different between them. In conclusion, our results suggest that modulation of specific IgG4 response and specific IgE response might be involved in the early and late symptom relief during immunotherapy, respectively. However, further studies might be necessary to definitively establish the clinical roles of specific IgE and specific IgG4 in immunotherapy.
Real-time Detection of Circulating Apoptotic Cells by in Vivo Flow Cytometry (2005)

Survival of cancer cells in the circulation is an important step in metastasis. However, the fate of circulating tumor cells is difficult to assess with conventional methods that require blood sampling. We report the first in situ measurement of circulating apoptotic cells in live animals using in vivo flow cytometry, a novel method [1–3] that enables real-time detection and quantification of circulating cells without blood extraction. Injected cancer cells undergo cell death within 1–2 hr after entering the mouse circulation. Apoptotic cells are rapidly cleared from the circulation with a half-life of ~10 min. Real-time monitoring of circulating apoptotic cells can be useful for detecting early changes in disease processes, as well as for monitoring response to therapeutic intervention. To detect circulating apoptotic cells in vivo, annexin-V conjugated to Alexa Fluor 647 (AF647) was used to label exposed phosphatidylserine on the cell surface. The long wavelength of AF647 fluorescence (Molecular Probes, OR) allows its detection through blood with minimum attenuation by red blood cells. In initial studies conducted to demonstrate that our instrument had sufficient sensitivity to detect individual annexin-Vlabeled apoptotic cells in vivo, we used MatLyLu prostate cancer cells pretreated with camptothecin [4] as a positive control. We verified that >80% of the camptothecin-treated cells undergo apoptosis by conventional flow cytometry (i.e., >80% of the treated cells were FITC–annexin V positive and propidium iodide negative). The camptothecin-treated cells were then labeled with the AF647-conjugated annexin-V and injected into the mouse intravenously. The circulating annexin-V + cells were measured by focusing a He–Ne laser beam onto an ear vessel and detecting the fluorescent bursts as individual cells flowed
Supplementary Materials and Methods from The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis (2023)

&lt;p&gt;This documents contains the materials and methods of experiments described in supplementary data&lt;/p&gt;
Phthalocyanine blue in aqueous solutions (2014)

Natively insoluble, unsubstituted Cu(II) phthalocyanines can be solubilised in water by the aid of nano-clays as colloidal α-CuPc and monomeric CuPc.
Conjugated Ladder-Type Polymer with Hexaazatriphenylene Units as a Cathode Material for Lithium, Sodium, and Potassium Batteries (2021)

A ladder-type conjugated polymer with hexaazatriphenylene moieties is reported, and its application as a cathode material for Li-, Na-, and K-based batteries is assessed. The material demonstrates specific capacities of 170–180 mA h g–1 at 0.1 A g–1, and up to 113 mA h g–1 at 5 A g–1 (charge/discharge in ∼80 s). It also shows superior cycling stability, especially in potassium cells that show no capacity fade after 4000 cycles at 5 A g–1. Charge–discharge processes of the material are probed using operando Raman spectroscopy.
Involvement of Hedgehog and FGF signalling in the lamprey telencephalon: evolution of regionalization and dorsoventral patterning of the vertebrate forebrain (2011)

Dorsoventral (DV) specification is a crucial step for the development of the vertebrate telencephalon. Clarifying the origin of this mechanism will lead to a better understanding of vertebrate central nervous system (CNS) evolution. Based on the lamprey, a sister group of the gnathostomes (jawed vertebrates), we identified three lamprey Hedgehog (Hh) homologues, which are thought to play central signalling roles in telencephalon patterning. However, unlike in gnathostomes, none of these genes, nor Lhx6/7/8, a marker for the migrating interneuron subtype, was expressed in the ventral telencephalon, consistent with the reported absence of the medial ganglionic eminence (MGE) in this animal. Homologues of Gsh2, Isl1/2 and Sp8, which are involved in the patterning of the lateral ganglionic eminence (LGE) of gnathostomes, were expressed in the lamprey subpallium, as in gnathostomes. Hh signalling is necessary for induction of the subpallium identity in the gnathostome telencephalon. When Hh signalling was inhibited, the ventral identity was disrupted in the lamprey, suggesting that prechordal mesoderm-derived Hh signalling might be involved in the DV patterning of the telencephalon. By blocking fibroblast growth factor (FGF) signalling, the ventral telencephalon was suppressed in the lamprey, as in gnathostomes. We conclude that Hh- and FGF-dependent DV patterning, together with the resultant LGE identity, are likely to have been established in a common ancestor before the divergence of cyclostomes and gnathostomes. Later, gnathostomes would have acquired a novel Hh expression domain corresponding to the MGE, leading to the obtainment of cortical interneurons.
Enhancement of joint fluid with intravenously administered gadopentetate dimeglumine: technique, rationale, and implications. (1993)

This study reports findings on joint fluid enhancement after intravenous administration of gadopentetate dimeglumine. Ten subjects were studied: two asymptomatic volunteers and eight patients with suspected meniscal tears. The subjects underwent imaging at 1.5 T before, immediately after, and 42-60 minutes after intravenous administration of gadopentetate dimeglumine. The rate of fluid enhancement was assessed in three subjects, and the effects of exercise were studied. All subjects exhibited enhancement of joint fluid. Mean fluid enhancement for patients was 137% on initial and 262% on delayed images obtained after exercise. Exercise increased the rate and degree of fluid enhancement and distributed contrast material uniformly throughout the joint. The arthrographic effect of the fluid enhancement increased the number of perceived cartilage defects. This study documents enhancement of joint fluid in healthy subjects and in those with effusions. The arthrographic effect may provide a more convenient alternative to intraarticular injection of gadopentetate dimeglumine for MR arthrography.
Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer (2007)

14543 Background: S-1 is a novel, orally administered 5-FU analogue and is known of radiosensitizer. The aim of this study was to establish the feasibility and efficacy of S-1 in combination with weekly irionotecan with concurrent pelvic radiotherapy (RT) in patients with locally advanced rectal cancer. Methods: Clinical stage T3–4 or N+(on MRI) rectal adenocarcinoma patients received weekly irinotecan 40mg/m 2 (day1,8,15,22,29) and S-1 at dose levels of 40, 50, 60 and 70mg/m 2 (5days a week from day 1 to 38) according to phase I methodology. Concurrently conventional RT was given at daily fractions of 1.8 Gy on 5 days a week for a total dose of 50.4 (45 + 5.4)Gy. Surgery was performed 4–8 weeks following completion of chemoradiation. Results: A total 16 patients (10M/7F, median age 46 years, ECOG PS0–1) were enrolled between August 2005 and July 2006. One pt withdrew the consent during CCRT. Dose-limiting toxicity (DLT) occurred at 50mg/m 2 of S-1 in one of six pts (G4 cerebral infarction). At dose of 60, 70mg/m 2 of S-1, no DLT occurred. G3/4 toxicties were rare. Fifthteen pts underwent surgery and R0 resection was achieved in 13 pts. Four pts (25.0%) had a pathological complete response. Conclusions: The recommended dose (RD) for further study is S-1 70mg/m 2 with irinotecan and radiotherapy. Neoadjuvant S-1/irinotecan/RT is feasible and well tolerated. Phase II trial is being conducted. No significant financial relationships to disclose.
The Use of ID Reader-Authenticators in Secure Access Control and Credentialing (2008)

Knowing who is entering, and whether they should be granted access, is key information for many types of military, government and commercial facilities. In many situations, access is granted based on an Identification Document (ID) such as a driver's license, passport, visa, or other specialized ID card. Although screeners are trained to detect false IDs, they have the daunting task of trying to do this within a few seconds for large numbers of people and types of documents on a daily basis. Newer cost effective ID Reader-Authenticators can add a high degree of automation and accuracy to the secure access control process. Available in a variety of physical configurations, they can automatically read IDs in full color at high resolution with multiple light sources, extracting image fields such as photos, as well as data fields, whether from text, barcodes, magnetic stripes, or embedded chips. The data extracted can be vetted against external watchlists without compromising privacy. They can process most currently issued IDs whether or not they contain machine readable enhancements. IDs can be authenticated via a wide variety of tests based on detecting embedded security features. Reader-Authenticators are particularly useful in the enrollment process (as part of new government ID initiatives) to avoid issuing IDs based on false breeder documents. Secure access control, whether at a national border, secure installation, lobby of a building, or airport screening area, can be enhanced with the use of today's advanced Reader-Authenticator technology.
Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: impact on quality of life (2014)

Natalizumab was the first monoclonal antibody to be approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) based on its short-term efficacy and overall tolerability. However, the incidence of treatment-associated progressive multifocal leukoencephalopathy (PML), an infection of the brain caused by the John Cunningham virus, jeopardized this efficacious treatment from the beginning. Eight years after licensing of natalizumab, long-term studies confirm the considerable and sustained efficacy of natalizumab, although the PML complication still threatens one of the most successful treatments available for RRMS. During these years, considerable progress has been made in identification of risk factors that allow more effective management of PML risk. In addition, long-term studies to define better when to start or stop treatment and to optimize treatment strategies after cessation of natalizumab are ongoing, and hopefully will improve management and will allow natalizumab to remain as a valuable therapeutic option for patients with highly active RRMS.
Copper‐hydrogenated soybean and linseed oils: Composition, organoleptic quality and oxidative stability (1973)

Abstract Copper and nickel hydrogenations give a wide distribution of double bonds in the monoene fraction from both reduced soybean and linseed oils. With copper catalysts, high pressure hydrogenation reduces the extent of this double bond distribution when compared with low pressure hydrogenation. With nickel catalysts, some Δ17‐octadecenoate is formed but less than with a copper catalyst. In room odor evaluations, copper‐hydrogenated soybean (CuHSB) oil gave higher scores and lower fishy responses than nickel‐hydrogenated soybean oil after both had been exposed to fluorescent light. A mixture of CuHSB oil (33%) and peanut oil received room odor scores equal to or better than peanut oil alone, whether light exposed or not. Although hydrogenated products with remarkable stability to oxidation were obtained by copper hydrogenation of linseed oil, these oils have lower organoleptic stability when compared to nickel‐hydrogenated, winterized soybean oil.
Linguistically quantified thresholding strategies for text categorization. (2003)

A new thresholding strategy for a text categorization problem is proposed. It is based on Zadeh’s calculus of linguistically quantified propositions. The strategy may be also interpreted in terms of fuzzy integral.
Training data collection system for a learning-based photographic aesthetic quality inference engine (2010)

We present a novel data collection system deployed for the ACQUINE - Aesthetic Quality Inference Engine. The goal of the system is to collect online user opinions, both structured and unstructured, for training future generation learning-based aesthetic quality inference engines. The development of the system was based on an analysis of over 60,000 user comments of photographs. For photos processed and rated by our engine, all users are invited to provide manual ratings. The users can also choose up to three key photographic features that the user liked, from a list, or to add features not in the list. Within a few months that the system is available for public used more than 20,000 photos have received manual ratings and key features for over 1,800 photos have been identified. We expect the data generated over time will be critical in the study of computational inferencing of visual aesthetics in photographs. The system is demonstrated at http://acquine.alipr.com
В. Н. Хлебников (д.т.н., зав. лаб.) 1 , П. М. Зобов (к.т.н., зам. зав. лаб.) 1 , И. Р. Хамидуллин 1 , Ю. Ф. Рузанова (маг. н.с.) 1 , П. А. Гущин (н.с.) 2 , В. А. Винокуров (д.х.н., проф. зав. каф.) 2 Перспективные пути осуществления в России проектов захоронения техногенного CO2 с получением эффекта от добычи нефти (2009)

является началом международного сотрудничества в этойобласти. Отношение в мире к проблемам сокращения эмиссии и захоронению (секвестрации) техногенных парниковых газов неоднозначно. Наибольшее внимание к вопросамуменьшения эмиссии парниковых газов и ихзахоронению уделяется в Европе, особеннов Норвегии
On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes (2009)

The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain is the primary target of the humoral immune response. In particular, the C-terminal Ig-like domain III of E, which is exposed at the surface of the viral particle, forms an attractive antigen for raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against a dengue virus (DENV) serotype 2 recombinant domain III, cross-reacts with corresponding domains from the other three DENV serotypes and also with West Nile virus. mAb 9F12 binds with nanomolar affinity to a conserved epitope that maps to the viral surface comprising residues 305, 307, 310 and 330 of the E protein. mAb 9F12 neutralizes all four DENV serotypes in plaque reduction assays. We expressed a single-chain Fv from 9F12 that retains the binding activity of the parent mAb. Adsorption and fusion inhibition assays indicate that mAb 9F12 prevents early steps of viral entry. Its virus inhibition activity and broad cross-reactivity makes mAb 9F12 a suitable candidate for optimization and humanization into a therapeutic antibody to treat severe infections by dengue.
Electron Diffraction Based Tilt Angle Measurements in Electron Tomography (2014)

Electron tomography can provide three dimensional (3D) visualization of nanoscale objects in a transmission electron microscope (TEM) from a tilt series of projected images. The accuracy of the 3D reconstruction depends on quality of input parameters, including accurate alignment in real space and accuracy of tilt and azimuth angle measurements. Here we present an electron diffraction-based in-situ method that allows accurate measurement of the relative tilt (α) and azimuth (β) angles.
Visualization of rotating cavitation in a centrifugal pump (2022)

Abstract In this study, unsteady cavitation in a centrifugal pump that had 3 blades was visualized in experiments. Cavitation behavior was photographed by using a high-speed camera from the axial direction. To observe rotating cavitation, its aspects were visualized using a high-speed camera. The experiment was performed at rotational speed of 825 rpm with a centrifugal pump under reduced pressure. Rotating cavitation occurred on the suction side of blades under the condition of flow rates lower than the best efficiency point. In addition, observed rotating cavitation was super-synchronous rotating cavitation, which rotates at a faster speed than the impeller in absolute coordinate form. As a result of frequency analysis of the brightness value on the channel, propagation velocity ratios, which is the ratio of the propagation velocity of the cavity to the rotational velocity of the impeller were 1.2 - 1.3. It was confirmed that the propagation velocity ratio of rotating cavitation in the centrifugal pump is close to that of rotating cavitation in the inducer even when the specific speed and Reynolds number are different.
Noninvasive Ultrasound Imaging of Carotid Intima Thickness (2010)

Atherosclerotic cardiovascular disease is the leading cause of mortality in the West and is a rapidly growing problem worldwide. Long subclinical incubation period of atherosclerosis and earliest involvement of the vessel wall provide an opportunity to evaluate the presence of atherosclerosis by imaging arterial wall and initiate treatment measures. Assessment of thickness of intima-media layer of the vessel wall as well as early plaques by ultrasound is the most sensitive, reliable, noninvasive, and safe method to detect those at risk. Carotid artery vessel wall assessment in the form of intima-media thickness (IMT) has been identified since the late 1970s as a sensitive tool to detect atherosclerosis, predict its sequelae, and detect its progression and regression. Recent studies have shown that the presence of carotid plaques is also a strong predictor of disease, independent of carotid IMT. The technique has been recommended by writing groups such as American Heart Association as a useful tool for risk stratification in those with unclear or intermediate risk of cardiovascular disease. Validated reference databases exist for reporting purposes. Several automated robust softwares are now available that allow automated measurement of IMT by edge detection algorithms.
Aneurysm Clipping after Endovascular Treatment with Coils: A Report of Eight Patients (1996)

Between January 1990 and December 1994, patients with subarachnoid hemorrhage related to ruptured aneurysms who were referred to our institution were treated by neurosurgical and neuroradiological teams. In each patient, the respective indications for neurosurgical or endovascular treatment were discussed, taking into consideration patients' age and the morphological and topographical aneurysm features. We report eight cases of patients with subarachnoid hemorrhage who underwent operations after primary endovascular procedures (Hunt and Hess scores III, IV, and V). The indications for surgical treatment were as follows. First, deliberate partial occlusion of the aneurysm (two aneurysms of the internal carotid artery and one aneurysm of the anterior communicating artery) was performed to obtain only partial clotting of the aneurysm sac by free coils. However, this procedure was discontinued in favor of the use of Guglielmi detachable coils. The second indication was partial occlusion after an endovascular procedure (two aneurysms of the middle cerebral artery and one internal carotid artery aneurysm). The third indication was re-expansion of the aneurysm 1 year after the endovascular treatment (one middle cerebral artery aneurysm). The final indication was secondary rupture of the aneurysm sac and false aneurysm around the migrating coil (one aneurysm of the pericallosal artery). During surgery, the aneurysm sac appeared translucent. The coils bulged out and stretched the aneurysm sac. One ruptured the membrane leading to a subarachnoid hemorrhage during the endovascular procedure. No hemorrhage occurred during the surgical clipping. Aneurysm obliteration was easily performed, especially when the packing was partial, but was very difficult when the complete aneurysm closure led to a stenosis of the parent vessel. A giant sylvian aneurysm rest, visible only with angiography, was left untreated. This series illustrates an original experience, which led us to conclude that aneurysm surgery with coils in place is not as difficult as is often thought.