gebhart/patrepeval huggingface dataset:
Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis (2014)

Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermethylation could be reversed through endogenous mechanisms and whether such reversal of hypermethylation is a constituent of the antifibrotic activity of bone morphogenic protein 7 (BMP7). We show that successful inhibition of experimental kidney fibrosis through administration of BMP7 associates with normalization of Rasal1 promoter hypermethylation. Furthermore, this reversal of pathologic hypermethylation was achieved specifically through Tet3-mediated hydroxymethylation. Collectively, our findings reveal a new mechanism that may be exploited to facilitate therapeutic DNA demethylation to reverse kidney fibrosis.
Stable Flies, Stomoxys calcitrans L. (Diptera: Muscidae), Improve Offspring Fitness by Avoiding Oviposition Substrates With Competitors or Parasites (2020)

Oviposition site selection by gravid female insects is an important determinant in species distribution, abundance, and population dynamics. Females may assess the suitability of a potential oviposition substrate by using cues from conspecific or heterospecific individuals already present. Here, we assessed whether the presence of conspecific or heterospecific larvae and parasites influenced oviposition decisions by the stable fly, Stomoxys calcitrans (Linneaus). Using dual and multiple-choice oviposition bioassays, we found that gravid female S. calcitrans avoided substrates with conspecific larvae, the larvae of house flies, Musca domestica (Linneaus), and the mite Macrocheles muscaedomesticae (Scopoli). Avoidance of conspecific and heterospecific larvae persisted in the dark, suggesting that this behaviour is mediated by chemical rather than visual cues. When we reared S. calcitrans in the presence of conspecific larvae and the larvae of house flies at different densities we found that this negatively affected emergence time, larval weight, larval survival, pupal weight, pupal survival, and adult weight. We also demonstrated that individuals of S. calcitrans developed in the presence of mites exhibited low egg hatchability, and poor larval and adult survival. Our study provides additional support for the “preference-performance” hypothesis in S. calcitrans, with gravid females preferring to lay eggs on a substrate that will enhance offspring fitness. We recommend that the chemical cues involved in avoidance by gravid female S. calcitrans of substrates with conspecific and heterospecific larvae should be elucidated. This could lead to the discovery of repellent chemicals important for S. calcitrans management.
Clinical investigation compared with the effects of the bee-venom Acupuncture on knee joint with osteoarthritis (2001)

Objective: This study is designed to find out the effects of the Bee-Venom Acupuncture on knee joint with osteoarthritis. Methods: We are investigated that outpatients suffer from knee joint pain deciphered at the division of Acupuncture in Jaseng oriental medicine hospital from the 13, July 1999 to unti111, November 2000. We make an estimated of the score from both before or after its treatment about 70 cases of diagnostic patient with the osteoarthritis of knee joints by biochemical method and X-RAY analysis, we observed in the progress of symptoms. Results: These results found that sex distinction with a disease caused much more female than male at the ratio of I to 5.36 in the proportion of males to females, jobs is mainly ranked with a housewife and approximately 82.9% of cases before our hospital have ever treated at the other clinics or hospitals. On the hand, the distribution interval of a case history is mainly followed by disease in below 6 month, interval of the period-treatment is mainly gone within 3 month and frequency of treatment is examined into II to 15 times, more than 16 times and below 10 times, respectively. We are estimated with the score of functional barrier from both before or after its treatment against osteoarthritis' patients and produced in the usefulness from the totally point of fields except the aid-device after its treatment In summary, these results demonstrated that Bee Venom, Acupuncture enhanced more than 82.9% to the improvement of treatment and p<0.05 considered to be statistically significant. Conclusion: These results suggest that Bee-venom Acupuncture may be playa role in the significant usefulness and have need of actively application for the clinical trials against osteoarthritis' patients.
Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers (2018)

Both RNC cigarettes were associated with decreased puffing and urinary biomarker exposure but not with decreased daily cigarette consumption or CO levels. The NMR did not moderate associations at the nicotine levels tested, suggesting that fast metabolizers may not be at greater risk of increasing use or exposure from these products should the FDA mandate an RNC standard for cigarettes.
Resistivity control of sputtered amorphous-silicon by ion-implantation (1980)

Abstract The resistivity of a hydrogenated sputtered amorphous-silicon is controlled by using room temperature implantation of P+. It is found that the defects produced by implantation can be minimized by annealing at 300°C in an H2 atmosphere, and also found that there is a threshold implanted dose, beyond which the resistivity begins to be controlled by changing the dose.
Rules-Based Object Clustering: A Data Structure for Symbolic VLSI Synthesis and Analysis (1986)

Object clustering is a data structure expressly binding analysis to support the incremental symbolic synthesis of high performance VLSI devices. Utilization of abstraction allows technology independent and technology dependent design entities to be represented as symbolic objects. This data structure supports a hierarchical representation of a VLSI device that equally applies to top-down or bottom-up synthesis. Processing concurrency is exploited in an interactive design environment centered around commercially available CAD work stations. As the designer is interactively composing the symbolic representation of circuit topology to implement a specific function, a rules-based algorithm performs the integration of the new object into the existing object clustering data structure. Neighboring relationships between objects are determined by hierarchical object-pair intersection and underlie the algorithms performing electrical and physical design rule checking, node topology extraction for circuit analysis, logic simulation, and testability analysis, and mask geometries generation. Object clustering is a robust data structure ideally suited to symbolically represent VLSI device designs, while facilitating analytical exploration and incremental synthesis.
Resolving pseudosymmetry in γ-TiAl using cross-correlation electron backscatter diffraction with dynamically simulated reference patterns (2018)

Pseudosymmetry is a phenomenon that occurs when grains with different lattice parameters produce nearly identical diffraction patterns such that conventional electron backscatter diffraction (EBSD) techniques are unable to unambiguously differentiate the lattice orientations. This commonly occurs in materials with near-unity tetragonality, such as γ-TiAl. The current study uses cross-correlation EBSD to resolve pseudosymmetry in γ-TiAl. Three dynamically simulated reference patterns are generated for each point in the scan, one for each of the three potential pseudosymmetric orientations, which are subsequently correlated with the original pattern using six different methods in order to identify the correct orientation. The methods are first applied to a scan of dynamically simulated patterns, which is used to evaluate the sensitivity of the method to pattern resolution, pattern noise and pattern center error. It was determined that all six methods were 100% successful up to about 13 µm of pattern center error and pattern resolutions of about 80 × 80 pixels, and hence the methods were applied to an experimental sample of lamellar γ-TiAl. A hybrid combination of two of the methods was shown to successfully select the correct pseudosymmetry for about 96% of the points in the scan, improving upon the 70% accuracy of the Hough-based methods for the current study and 90% accuracy for previous studies resolving pseudosymmetry in lamellar γ-TiAl.
Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion (1994)

To evaluate the effect of chronically elevated adenylyl cyclase, we targeted the expression of a constitutively active mutant alpha-subunit (alpha s+) of Gs to the insulin-producing pancreatic beta-cells of transgenic mice. As assessed by the polymerase chain reaction, expression of alpha s+ mRNA was restricted to the transgenic pancreas. Histological analysis by light microscopy and immunohistochemistry for insulin, glucagon, and somatostatin appeared normal in transgenic islets. Pancreatic insulin content was quantitatively the same for alpha s+ transgenic and control mice. Comparisons of glucose homeostasis, insulin secretion, and islet cAMP revealed the expected differences between alpha s+ transgenic and control mice; in every case, however, responses to glucose alone were normal, and the differences were observed only when measurements were performed in the presence of isobutylmethylxanthine (IBMX), an inhibitor of cAMP phosphodiesterase. 1) In vivo, ip glucose tolerance was normal in alpha s+ transgenics; when ip glucose was preceded by administration of IBMX, the rise in blood glucose was approximately 33% less in the transgenic than in the control mice. 2) Insulin secretion from the perfused pancreas stimulated sequentially with 11 and 22 mM glucose caused characteristic first and second phase insulin release that did not differ between transgenic and control pancreases. IBMX increased biphasic insulin release from all pancreases, but caused a 2-fold greater than normal release from the transgenics. 3) Similarly, batch-incubated alpha s+ and control islets secreted equivalent amounts of insulin in the presence of glucose (22 mM) alone, whereas the combination of glucose plus IBMX was twice as effective on alpha s+ islets. 4) Islet cAMP levels paralleled insulin secretion; in the presence of IBMX, but not glucose alone, cAMP was increased 2-fold more in alpha s+ vs. control islets. We conclude that expression of constitutively active alpha s mutant in pancreatic beta-cells of transgenic mice is functionally effective, causing the physiological phenotype of increased islet cAMP and insulin secretion. However, these changes are uncovered only in the presence of IBMX; without IBMX, glucose homeostasis and islet function appear normal. This normalization, or counterregulation, of cAMP synthesis presumably is accomplished by a compensatory increase in cAMP degradation, possibly via increased activity of cAMP phosphodiesterase.
Impact of Humidity on Adhesion between Rough Surfaces (2000)

The surface forces apparatus was used to study the variation with relative humidity of adhesion between mica and rough gold films coated with either a hydrophobic or hydrophilic self-assembled monolayer (SAM). Pull-off forces, as a function of relative humidity, were measured between mica and gold coated with either n-octadecanethiol or 1-hydroxylunicosanethiol. For the alcohol-terminated SAM, pull-off forces increase from 370 mN/m (dry conditions) to 845 mN/m (saturated conditions). For the methyl-terminated SAM, pull-off forces increase from 160 mN/m (dry conditions) to 643 mN/m (saturated conditions). A quartz crystal microbalance was used to obtain adsorption isotherms on the two different SAMs. Angstrom-level changes in adsorbed layer thickness are associated with marked changes in measured adhesion forces.
Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents (2020)

Based on evidence available as of December 20, 2020, the panel suggests against routine administration of monoclonal antibody therapy (bamlanivimab, or casirivimab and imdevimab), for treatment of COVID-19 in children or adolescents, including those designated by the FDA as at high risk of progression to hospitalization or severe disease. Clinicians and health systems choosing to use these agents on an individualized basis should consider risk factors supported by pediatric-specific evidence and ensure the implementation of a system for safe and timely administration that does not exacerbate existing healthcare disparities.
Selective Catalytic Hydrogenations of Nitriles, Ketones, and Aldehydes by Well-Defined Manganese Pincer Complexes (2016)

Hydrogenations constitute fundamental processes in organic chemistry and allow for atom-efficient and clean functional group transformations. In fact, the selective reduction of nitriles, ketones, and aldehydes with molecular hydrogen permits access to a green synthesis of valuable amines and alcohols. Despite more than a century of developments in homogeneous and heterogeneous catalysis, efforts toward the creation of new useful and broadly applicable catalyst systems are ongoing. Recently, Earth-abundant metals have attracted significant interest in this area. In the present study, we describe for the first time specific molecular-defined manganese complexes that allow for the hydrogenation of various polar functional groups. Under optimal conditions, we achieve good functional group tolerance, and industrially important substrates, e.g., for the flavor and fragrance industry, are selectively reduced.
Clinical outcome of pancreatic cancer patients with diabetes mellitus: is diabetes a poor prognostic factor? Highlights from the "2010 ASCO Annual Meeting". Chicago, IL, USA. June 4-8, 2010. (2010)

Diabetes mellitus and its related factors such as hyperinsulinemia have been linked to various cancer risks and outcomes. Previous research has offered inconsistent results in terms of relationship between diabetes and pancreatic cancers. Establishing clear association between these two entities may guide us in improving clinical outcomes of pancreatic cancer patients. Two abstracts that examined the association between diabetes mellitus and pancreatic cancer are updated in this paper. Herein, the authors report updated information from the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting in association between pancreatic cancer and diabetes mellitus. The present paper illustrates insufficient knowledge base to draw a conclusion in this topic. However, validation and understanding of the association could have significant clinical implications with respect to cancer prevention, early detection, and treatment. As such, further investigations are warranted to explore the link diabetes and pancreatic cancers.
Development of the Compact Flash Evaporator System for Exploration (2007)

&lt;div class="htmlview paragraph"&gt;This paper will discuss the status of the Compact Flash Evaporator System (CFES) development at NASA Glenn. Three alternative heat sink technologies are being developed under Thermal Control for Advanced Capabilities within the Exploration Technology Development Program. One of them is CFES, a spray cooling concept related to the current Space Shuttle Orbiter Flash Evaporator System (FES). In the CFES concept, water is sprayed on the outside of a flat plate heat exchanger, through which flows the vehicle's primary vehicle heat transfer fluid. The steam is then exhausted to space in an open-loop system. Design, fabrication and testing of the CFES at NASA's Glenn Research Center will be reported.&lt;/div&gt;
Auditory product design (2009)

Researchers at the Crossmodal Laboratory in Oxford have been developing a new experimental technique, based on a robust psychophysical paradigm adopted from cognitive psychology, which allows to evaluate the effect of changing the sound made by a particular product on people's product perception. The technique also enables the evaluation of a range of novel product sounds without having to generate products for testing that have the desired auditory profiles, so potentially speeding up the product development and innovation process. One trend that is emerging in a number of areas where product sound design is popular, is the move away from the evaluation and subsequent re-engineering of prototypes with a particular sound to the increased use of simulation tools and techniques, and the greater use of synthesized product sounds in the product sound design cycle. In future, research in cognitive neuroscience can be translated into the formulation of design principles that will enable industrial designers to stimulate the senses of their target customers more effectively.
Frequency Estimation of Multiple Components using Chinese Remainder Theorem (2018)

Frequency estimation is a very important step to correctly detect a signal components. Nowadays, frequency estimation is required in many applications such biomedical signals, spectrum sensing, and military systems. However, as most of these applications require wide bands signals, the implementation of conventional sampling schemes at the Nyquist rate becomes very challenging. Hence, it is primordial to propose advanced frequency estimation methods at sub-Nyquist sampling rates. In literature, Chinese remainder theorem (CRT) has been proposed to estimate the components of a single frequency signal. However, its extension to multiple components has not been addressed due to the complexity of the estimation algorithm. In this paper, we extend the CRT further by proposing a new approach for frequency estimation of a signal with multiple components as long as they have a particular pattern. The results have been validated by Monte-Carlo simulations and compared with the well-known MUSIC algorithm.
Designing Free Sofware for Marketing: A Game Theoretic Approach (2003)

We develop a vertical differentiation game-theoretic model that addresses the issue of designing free software samples for attaining follow-on sales. When software samples are akin to durable goods, a Monopolist giving a free sample away is likely to engender the cannibalization of sales of its commercial product. We analyze the optimal design of free software according to two characteristics: the trial time allotted for sampling (potentially renewable) and the proportion of features included in the sample. We find that these two dimensions play different roles whenever the software product is innovative or standard. We draw implications regarding the effectiveness of marketing strategies depending on the type of software product offered by a Monopolist.
Infrared thermography for detailed registration of thermoregulation in premature infants (2013)

Via IRT, it is possible to detect fluctuations in temperature of premature infants. The cooling in I2 after SSC should be taken into account before routine daily care.
Peripheral dose distributions for a linear accelerator equipped with a secondary multileaf collimator and universal wedge (2002)

The American Association of Physicists in Medicine Task Group 36 (AAPM TG-36) data can be used to estimate peripheral dose (PD) distributions outside the primary radiation field. However, the report data does not apply to linear accelerators equipped with a multileaf collimator (MLC) and universal wedge (UW). Tertiary multileaf collimators have been shown to significantly affect PD distributions and TG-36 reported data. Measurements were performed to evaluate PD distributions for a linear accelerator equipped with a secondary MLC, backup diaphragms, and UW. This data can be used to compliment the TG-36 report for estimation of doses to critical structures outside primary radiation fields. For the evaluated linear accelerator, an MLC is incorporated in the upper secondary collimator jaws. Backup shielding diaphragms are located underneath the MLC. At the nominal collimator position, the MLC and the backup diaphragm provide collimation primarily in the transverse direction. Conventional, solid tungsten-alloy jaws, located underneath the backup diaphragms, provide secondary collimation in the longitudinal direction. The universal wedge provides dose modulation in the direction of the conventional jaws. Measurements were made with an ionization chamber inserted into a water-equivalent plastic phantom with the secondary collimator and MLC settings of , and with and without UW. Data was acquired along the machine's longitudinal axis for 6, 10, and 18 MV photons. Peripheral dose distributions were measured with the collimator rotated to 0° and 270° for open field measurements and to 0°, 180°, and 270° for wedged fields (IEC 1217). This allowed evaluation of peripheral dose distributions as a function of collimator rotation. Wedged fields were normalized to deliver the same dose at the depth of maximum dose on the central axis as open fields. The measured PD distributions were generally comparable to data reported by TG-36. At distances close to the field edge (less than 30 or 40 cm), the measured PD distributions were lower when the measurement point was shielded by solid jaws than with MLC and backup diaphragm. At longer distances, this trend reversed for all energies and evaluated field sizes. However, the difference in PD distribution with collimator rotation was not large enough to warrant strategic positioning of the collimator to reduce dose to critical structures outside the primary radiation field. Because internal scatter dominates close to the field edge, wedged PD distributions were comparable to open field doses at distances closer than 30 cm. However, at distances larger than 30 cm from the field edge, wedged PD distributions were significantly grater than those for open fields due to increased contribution of leakage radiation. Increased leakage radiation is due to the increase in wedged field monitor units, which is related to a small wedge factor (0.27 to 0.29). PACS number(s): 87.53.–j, 87.66.–a
Track assignment (2002)

Routing is one of the most complex stages in the back-end design process. Simple routing algorithms based on two stages of global routing and detailed routing do not offer appropriate opportunities to address problems arising from signal delay, cross-talk and process constraints. An intermediate stage of track assignment between global and detailed routing proves to be an ideal place to address these problems. With this stage it is possible to use global routing information to efficiently address these problems and to aid the detailed router in achieving the wiring completions. In this paper we formulate routing as a three stage process; global routing, track assignment and detailed routing. We describe the intermediate track assignment problem and suggest an efficient heuristic for its solution. We introduce cost metrics to model basic effects arising from connectivity. We discuss extensions to include signal integrity and process constraints. We propose a heuristic based on weighted bipartite matching as a core routine. To improve its performance additional heuristics based on lookahead and segment splitting are also suggested. Experimental results are given to highlight the efficacy of track assignment stage in routing process.