gebhart/patrepeval huggingface dataset:
Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16 (2019)

Higher doses of PEG-asparaginase failed to improve outcome, but additional intrathecal therapy during early induction seemed to contribute to improved CNS control without excessive toxicity for high-risk patients.
Stereoisomer-uniform olefins (1968)

Homogeneous stereoisomeric olefins of the general formula I (R1 and R2 = alkyl, R3 = H and(or) alkyl) were prepd. by reacting a phosphorus ylide (general formula Ar3P+:C-HR) and a carbonyl compd. R2COR3 with stoichiometric amt. of a strong base, followed by addn. of a proton donor to convert the intermediate product into an olefin and triarylphosphine oxide. In a sample, the phosphorus ylide was prepd. by reacting Ph3P+EtCl- with PhLi (1 mole) in a mixt. of ether 3 and tetrahydrofuran 1 part at 0 Deg. The phosphorus ylide was reacted with 1 mole BzH, and the resulting betaine type intermediate was then reacted at -20 Deg with 1 mole PhLi. After .apprx.30 min. the mixt. was dild. with 2 moles tert-BuOH and afterthe addn. of 1.5 moles KOBu-tert stirred at 25 Deg for 1.5 hrs. b-Methylstyrene was isolated in 69% yield having trans to cis ratio 99:1. [on SciFinder (R)]
Short- and Long-Term Regulation of Tyrosine Hydroxylase in Chromaffin Cells by VIP and PACAPa (2006)

Whereas cholinergic neurotransmitters are responsible for the release of a substantial portion of the CAs released from rat chromaffin cells by activation of the splanchinc nerves, the present data suggest that noncholinergic neurotransmission appears to play a more substantial role in the short- and long-term homeostatic regulation of TH activity, which serves to maintain the stores of CAs for subsequent release. In addition, studies using the PKA-deficient PC12 cells provided the first direct evidence that PKA actually mediates the phosphorylation of Ser40 in situ.
Dediazoniation of arenediazonium ions. 24. Dual and triple substituent parameter evaluation of competitive heterolytic and homolytic dediazoniations of diazonium ions complexed with 18-crown-6 ether (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDediazoniation of arenediazonium ions. 24. Dual and triple substituent parameter evaluation of competitive heterolytic and homolytic dediazoniations of diazonium ions complexed with 18-crown-6 etherHiroyuki Nakazumi, Teijiro Kitao, and Heinrich ZollingerCite this: J. Org. Chem. 1987, 52, 13, 2825–2830Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/jo00389a033https://doi.org/10.1021/jo00389a033research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accurate reflectance prediction in multi-angle measurement (2008)

This study focuses on finding the best viewing angles so that accurate reflectance prediction could be achieved in multi-angle measurement of metallic and pearlescent samples. The root mean square error (RMSE) produced by the reconstruction from the first seven Principle component vectors (PCV), the cumulative contribution being 99.92 percent, were analyzed to find the best viewing angles 10&#xB0;, 65&#xB0;, 95&#xB0;, 120&#xB0;, 145&#xB0;, 155&#xB0; and 170&#xB0; in clock wise direction from the surface for illumination angle of 45&#xB0;. The error difference resulted by prediction using cubic interpolation and proposed Principle component analysis (PCA) based method were compared. The prediction by PCA based method outperforms the prediction by cubic interpolation. The method can be employed not only to metallic and pearlescent samples but to all non lambertian surfaces.
A note on a nonlinear functional differential system with feedback control (2009)

In this note we apply Avery-Peterson multiple fixed point theorem to investigate the existence of multiple positive periodic solutions to the following nonlinear non-autonomous functional differential system with feedback control \[\left\{\begin{array}{l} \frac{dx}{dt}=-r(t)x(t)+F(t,x_t,u(t-\delta(t))),\\ \frac{du}{dt}=-h(t)u(t)+g(t)x(t-\sigma(t)).\\ \end{array}\right.\] We prove the system above admits at least three positive periodic solutions under certain growth conditions imposed on $F$.
A RAPID METHOD FOR CALCULATING THE TRANSVERSAL STRAIN IN THE MOIRE TECHNIQUE ALONG SECTIONS OF SYMMETRY (1970)

An approximate rapid method is described for calculating in the moiré technique the transversal strain directly from the longitudinal strain distribution across sections of symmetry. The method is based on evaluation of the load transmitted through the section and is corroborated by two examples.
Recreational Diving Impacts on Coral Reefs and the Adoption of Environmentally Responsible Practices within the SCUBA Diving Industry (2016)

Recreational diving on coral reefs is an activity that has experienced rapidly growing levels of popularity and participation. Despite providing economic activity for many developing coastal communities, the potential role of dive impacts in contributing to coral reef damage is a concern at heavily dived locations. Management measures to address this issue increasingly include the introduction of programmes designed to encourage environmentally responsible practices within the dive industry. We examined diver behaviour at several important coral reef dive locations within the Philippines and assessed how diver characteristics and dive operator compliance with an environmentally responsible diving programme, known as the Green Fins approach, affected reef contacts. The role of dive supervision was assessed by recording dive guide interventions underwater, and how this was affected by dive group size. Of the 100 recreational divers followed, 88 % made contact with the reef at least once per dive, with a mean (±SE) contact rate of 0.12 ± 0.01 per min. We found evidence that the ability of dive guides to intervene and correct diver behaviour in the event of a reef contact decreases with larger diver group sizes. Divers from operators with high levels of compliance with the Green Fins programme exhibited significantly lower reef contact rates than those from dive operators with low levels of compliance. The successful implementation of environmentally responsible diving programmes, which focus on influencing dive industry operations, can contribute to the management of human impacts on coral reefs.
Formulation optimization, skin irritation, and efficacy characterization of a novel skin‐lightening agent (2012)

SMA-012 shows a good promise as a skin-lightening agent for cosmetic and therapeutic applications. Additionally, our study demonstrates the application of skin equivalent models as alternatives to animal testing in studying the regulation of skin pigmentation.
Three parameter flow cytometric analysis for simultaneous detection of cytokeratin, proliferation associated antigens and DNA content (1995)

Abstract The analysis of the cell cycle distributions by univariate flow cytometric DNA measurement has been widely applied in the clinic to determine kinetic parameters of human malignancies. A common problem with measurements of cell cycle phase distributions in tumor biopsy material is the presence of non‐malignant diploid cells. Furthermore, such a static measurement might not be accurate enough to describe the dynamic process of cell proliferation. For this purpose alternative methods have been developed to include BrdUrd incorporation or the presence of intrinsic proliferation associated markers such as PCNA or Ki67‐Ag into the analysis. However, the presence of nonmalignant diploid cells will influence also these bivariate analyses, especially in case of DNA‐diploidy of the tumor cells. Here we present a three parameter flow cytometric assay based on the simultaneous detection of cytokeratin, DNA and a proliferation associated marker, such as BrdUrd, PCNA or Ki67‐Ag. Based on the presence of cytokeratin, epithelial cells can be selected for a detailed cell cycle analysis. This method can be applied to frozen tissue, which makes this assay useful for multicentre clinical studies. © 1995 Wiley‐Liss, Inc.
A Framework for Cost-Aware Process Management: Cost Reporting and Cost Prediction (2014)

Organisations are constantly seeking efficiency gains for their business processes in terms of time and cost. Management accounting enables detailed cost reporting of business operations for decision making purposes, although significant effort is required to gather accurate operational data. Process mining, on the other hand, may provide valuable insight into processes through analysis of events recorded in logs by IT systems, but its primary focus is not on cost implications. In this paper, a framework is proposed which aims to exploit the strengths of both fields in order to better support management decisions on cost control. This is achieved by automatically merging cost data with historical data from event logs for the purposes of monitoring, predicting, and reporting process-related costs. The on-demand generation of accurate, relevant and timely cost reports, in a style akin to reports in the area of management accounting, will also be illustrated. This is achieved through extending the open-source process mining framework ProM.
Synthesis of (+)-Streptazolin (2006)

Streptazolin is a very unstable metabolite of Streptomyces viridochromogenes. The key step in this synthesis is the use of a silicon-tethered ring-closing metathesis followed by a protodesilylation to afix the stereochemistry of the ethylidene side chain. The overall yield from aminocyclopentenol A was 4.8% (16 steps).
The Ultrastructural Pathological Features of Congenital Microcoria (1989)

We describe the light microscopic, immunohistochemical, and electron microscopic findings in a sporadic case of congenital microcoria in a 72-year-old man with senile cataract. We demonstrated a lack of myofilaments and desmin in the stromal cytoplasmic processes of the anterior pigmented cells of the iris, although other features of muscle differentiation were present in these few surviving cell processes that normally form the pupil dilator muscle. Degenerative changes in anterior pigment cells and iris stromal atrophy were thought to be late secondary features of microcoria. The findings suggest that congenital microcoria results from a defect of intermediate filaments in the terminal fetal stages of differentiation of the anterior pigmented epithelial cell of the iris, with absence of myofilaments and consequent failure of development of a functional dilator pupil muscle.
Investigation on possibility of gravimetric transducer application for biosensors creation (1996)

В работе рассмотрены несколько различных подходов к использованию гравимет­рических преобразователей на основе кристалла кварца в плане создания иммун­ных и хемо-биосенсоров. Исследованы условия работы пьезокристаллов в раство­рах и предложены практические схемы генераторов, позволяющие работать в средах с повышенной вязкостью. Показаны преимущества резонансного метода проведения гравиметрических измерений при работе в проточной системе. Об­суждены результаты, полученные при выполнении модельных экспериментов, и подтверждена перспективность развития данного метода для создания иммуно­сенсоров.
Dihydroxylation of 1,7-Dioxaspiro[5.5]undec-4-enes (1993)

The highly stereoselective syn-hydroxylation of the unsaturated spiro acetals (4-8) with osmium tetraoxide is reported. In all cases, hydroxylation occurred from the ß-face giving the diols in which the hydroxy group at C5 is axial and anti to the C-O bond of the neighbouring tetrahydropyran ring.
Combined system of AC and DC electromagnetic field for stabilized flow in continuous casting (2005)

We evaluate the verification of combined system ac and dc electromagnetic field using magneto hydrodynamic calculation. For the effect of level magnetic flow (LMF) that gives the molten steel the breaking force in proportion to the velocity using dc magnetic field, we confirm that the velocity at meniscus becomes stabilized in the time domain and the space domain, though the conventional dual electromagnetic stirring is difficult to realize the stabilization of the meniscus flow dynamics. In the proposed process, it is also confirmed that the velocity at the inner mold is constant in spite of dc magnetic field.
Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism (2022)

Recent studies have shown promise for the use of probiotics in modulating behaviour through the microbiota-gut-brain axis. In the present study, we assessed the impact of two probiotic strains in mitigating autism-related symptomology in the BTBR <i>T<sup>+</sup> Itpr3<sup>tf</sup></i>/J mouse model of autism spectrum disorder (ASD). Male juvenile BTBR mice were randomized into: (1) control, (2) <i>Lr</i> probiotic (1 × 10<sup>9</sup> CFU/mL <i>Lacticaseibacillus rhamnosus</i> HA-114), and (3) <i>Ls</i> probiotic groups (1 × 10<sup>9</sup> CFU/mL <i>Ligilactobacillus salivarius</i> HA-118) (n = 18-21/group), receiving treatments in drinking water for 4 weeks. Gut microbiota profiling by 16S rRNA showed <i>Lr</i>, but not <i>Ls</i> supplementation, to increase microbial richness and phylogenetic diversity, with a rise in potential anti-inflammatory and butyrate-producing taxa. Assessing serum and brain metabolites, <i>Lr</i> and <i>Ls</i> supplementation produced distinct metabolic profiles, with <i>Lr</i> treatment elevating concentrations of potentially beneficial neuroactive compounds, such as 5-aminovaleric acid and choline. As mitochondrial dysfunction is often observed in ASD, we assessed mitochondrial oxygen consumption rates in the prefrontal cortex and hippocampus. No differences were observed for either treatment. Both <i>Lr</i> and <i>Ls</i> treatment reduced behavioural deficits in social novelty preference. However, no changes in hyperactivity, repetitive behaviour, and sociability were observed. Results show <i>Lr</i> to impart positive changes along the microbiota-gut-brain axis, exhibiting beneficial effects on selected behaviour, gut microbial diversity, and metabolism in BTBR mice.
A novel approach for treating type II endoleaks utilizing contrast-enhanced ultrasound (2021)

Endoleaks are a frequent and well-known complication after endovascular repair of aortic aneurysms. An endoleak can lead to increased intrasac pressure, sac enlargement, and potential aneurysm rupture. Type II endoleaks result from retrograde filling of aortic branch vessels and can be treated with surgical, endovascular, or direct percutaneous approaches. Direct percutaneous treatment typically involves embolization of the perfused endoleak cavity typically using a translumbar approach with fluoroscopic guidance. We illustrate a novel image-guided approach for percutaneous transabdominal endoleak treatment using contrast-enhanced ultrasound in combination with fluoroscopy.
Analysis of Skin Disposition of Flurbiprofen after Topical Application Using Dual Agar Gel Discs-Inserted Rats (2007)

Most of the drug fraction penetrating the skin after topical application is taken up by the cutaneous blood flow, although the rest directly migrates into deeper tissues such as the subcutis and muscle. A new in situ experimental hairless rat model was designed to distinguish these fractions of topically applied drugs. Flurbiprofen, a non-steroidal anti-inflammatory drug, was selected as the model drug. In this model, two agar gel discs were subcutaneously inserted into the abdominal region of hairless rats as a drug receptor, and a topical formulation containing the drug was placed above either side of the gel disc. Plasma and agar levels of flurbiprofen were followed every 2 h over 10 h. The migration fraction of the drug into the systemic circulation and that directly to subcutaneous tissues were calculated to be 99.8% and 0.2% against the total amount which penetrated the skin, and the drug ratios into agar gel from the systemic circulation and not from the systemic circulation (i.e. directly migrated from the formulation) were 16.0% and 84.0%, respectively, at 10 h. This in situ drug disposition profile in skin was similar to the in vivo profile calculated from the in vivo muscle amount of flurbiprofen using muscle clearance. These results clearly suggest that the present in situ experimental model is a valuable tool for easy analysis of the skin disposition of topically applied drugs.
Sonar echo statistics as a remote-sensing tool: Volume and seafloor (1986)

Sonar echoes from unresolved features tend to interfere with each other. When a sonar is moved through an area where features of interest are not resolved, echoes will fluctuate from ping to ping due to the interferences. These fluctuations are the subject of this paper. We classify both fish and the rough seafloor by analyzing the nature of echo fluctuations. Similar statistical techniques apply to all of the problems. We use the techniques to determine, from echo fluctuations, parameters that describe the physical situation. Fish: Two conditions are low density and high density of fish (density is defined as number of fish per unit volume), a) In the low-density case, fish are resolved and their individual echoes are distinguishable from each other. From single fish there are interferences between echoes from the anatomical features causing fluctuations. Echoes from resolved fish also fluctuate because of beampattern effects. After deconvolution (or "removal") of beam-pattern effects, echo amplitudes from resolved fish fit a Rician probability density function (pdf). b) In the high-density case, the fish are not resolved and echoes from individual fish overlap. These echoes interfere and cause the echoes to fluctuate. The Rayleigh pdf describes the instantaneous echo amplitude from a cloud or school of fish. We process echoes by picking the peak amplitude in a finite-time gate and obtain an extremal pdf. We examine both regions of density (a) and (b) and present methods we have developed to determine, from the nature of the fluctuations, properties such as fish size frequency distribution and possibly gross anatomical features, fish density, and to count occasional large fish swimming in a cloud of plankton or near the sea surface. Seafloor: Interference of echoes from individual protuberances such as rocks, nodules, and ripples causes fluctuations. The Rice pdf describes echo amplitudes from the seafloor. We combine Eckart acoustic-scattering theory for a downward-looking sonar and Rice statistics. As a result we describe echo fluctuations in terms of rms roughness of the seafloor and correlation area (product of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</tex> correlation distances) of the seafloor. We use boomer data to estimate seafloor microrelief as well as to predict echo fluctuations for a variety of other sonars.
The Polymerase Chain Reaction: A Powerful and Malleable Tool (1994)

Journal Article The Polymerase Chain Reaction: A Powerful and Malleable Tool Get access John J Sninsky John J Sninsky Roche Molecular Systems, 1145 Atlantic Ave., Alameda, CA 94501 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 40, Issue 4, 1 April 1994, Pages 651–652, https://doi.org/10.1093/clinchem/40.4.651 Published: 01 April 1994
Pancreatic islet ganglioside expression in nonobese diabetic mice: comparison with C57BL/10 mice and changes after autoimmune beta-cell destruction (1992)

Recent observations have shown that the presumed target antigen of cytoplasmic islet cell antibodies (ICA) has properties of a monosialo-ganglioside migrating between GM2 and GM1 standards (GM2-1) and that ICA binding is higher in nonobese diabetic (NOD) than in C57BL/10SnJ mouse pancreatic frozen sections. This study aimed to characterize the ganglioside expression in NOD mouse islets in comparison with the control C57BL/10SnJ strain, taking into account possible sex differences, variations with age, and changes after autoimmune beta-cell destruction. Thus, acidic glycolipid composition was analyzed 1) in isolated islets from 11-week-old female and male NOD mice and age-matched female and male C57BL/10SnJ mice, and 2) in whole pancreas of both NOD and control mouse strains at different ages (4, 8, and 18 weeks) and of female NOD mice before and after diabetes onset. The acidic glycolipid GM2-1 is expressed in isolated female NOD islets, male NOD islets, and C57BL/10SnJ mouse islets, but quantitative analysis showed an increased amount of GM2-1 in NOD vs. C57BL/10 islets. GM3 is a ganglioside fraction expressed in female and male NOD mice and not in the C57BL/10 strain, whereas GD3 characterizes the C57BL/10 strain islets. GM2-1 is the sole ganglioside fraction in the whole pancreas to clearly decrease with age in the NOD mouse, and diabetes onset in this strain is associated with a significant decrease in the expression of this component as well as of GM3, whereas other pancreatic ganglioside (GD3, GD1a, and GT1b) levels did not significantly decrease; no age-related ganglioside change was observed in the C57BL/10SnJ mouse. Interestingly, the observed increased ICA binding in NOD islets is paralleled by the increased expression of GM2-1 islet ganglioside, and beta-cell destruction in NOD mice is associated with a significant decrease in the amount of this ganglioside in the pancreas.
J/ψ and ψ(2S) production at forward rapidity in p+p collisions at s=510  GeV (2020)

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured the differential cross section, mean transverse momentum, mean transverse momentum squared of inclusive $J/\ensuremath{\psi}$, and cross section ratio of $\ensuremath{\psi}(2S)$ to $J/\ensuremath{\psi}$ at forward rapidity in $p+p$ collisions at $\sqrt{s}=510\text{ }\text{ }\mathrm{GeV}$ via the dimuon decay channel. Comparison is made to inclusive $J/\ensuremath{\psi}$ cross sections measured at $\sqrt{s}=200\text{ }\text{ }\mathrm{GeV}$ and 2.76--13 TeV. The result is also compared to leading-order nonrelativistic QCD calculations coupled to a color-glass-condensate description of the low-$x$ gluons in the proton at low transverse momentum (${p}_{T}$) and to next-to-leading order nonrelativistic QCD calculations for the rest of the ${p}_{T}$ range. These calculations overestimate the data at low ${p}_{T}$. While consistent with the data within uncertainties above $\ensuremath{\approx}3\text{ }\text{ }\mathrm{GeV}/c$, the calculations are systematically below the data. The total cross section times the branching ratio is BR $d{\ensuremath{\sigma}}_{pp}^{J/\ensuremath{\psi}}/dy(1.2&lt;|y|&lt;2.2,0&lt;{p}_{T}&lt;10\text{ }\text{ }\mathrm{GeV}/c)=54.3\ifmmode\pm\else\textpm\fi{}0.5(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}5.5(\mathrm{syst})\text{ }\text{ }\mathrm{nb}$.
Myocardium: Dynamic versus Single-Shot CT Perfusion Imaging (2013)

http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13121441/-/DC1.