gebhart/patrepeval huggingface dataset:
A multivariate study of diffuse reflectance infrared profiles of resin fractions from crude oils (2008)

Interfacially active fractions were separated from deasphaltened crude oils using adsorption onto different solid particle surfaces followed by desorption using combinations of different solvents. The fractions were studied using diffuse reflectance infrared fourier transform spectroscopy (DRIFT) and the resulting matrices of spectra analysed using principal component analysis (PCA). The analysis of the infrared spectra show that different functionalities can be separated using this adsorption/desorption procedure, and that the functionalities separated depend on the crude, adsorption surface and solvents used. A two step desorption procedure gave more variation in the spectra of the isolated resin fractions than a single desorption step.
From Coarse to Fine: Robust Hierarchical Localization at Large Scale (2019)

Robust and accurate visual localization is a fundamental capability for numerous applications, such as autonomous driving, mobile robotics, or augmented reality. It remains, however, a challenging task, particularly for large-scale environments and in presence of significant appearance changes. State-of-the-art methods not only struggle with such scenarios, but are often too resource intensive for certain real-time applications. In this paper we propose HF-Net, a hierarchical localization approach based on a monolithic CNN that simultaneously predicts local features and global descriptors for accurate 6-DoF localization. We exploit the coarse-to-fine localization paradigm: we first perform a global retrieval to obtain location hypotheses and only later match local features within those candidate places. This hierarchical approach incurs significant runtime savings and makes our system suitable for real-time operation. By leveraging learned descriptors, our method achieves remarkable localization robustness across large variations of appearance and sets a new state-of-the-art on two challenging benchmarks for large-scale localization.
Nanopatterned Ag substrates for SERS spectroscopy (2008)

Nanopatterned silver substrates with highly reproducible morphologies have been fabricated by micro-contact printing techniques and tested for SERS activity.
Laser cooling in a Fabry-Perot resonator (2002)

We develop a first-principles description of the mechanical effects of light on a single two-level atom in a Fabry-Perot interferometer. Our analysis is based on the plane-wave and semiclassical approximations, but within this context it yields general equations that include propagation effects and allow arbitrary parameters of the resonator. We then focus on the conditions under which the uniform field limit holds and derive an explicit expression for the cavity-induced force on the atom in the low saturation limit. We also provide a physical explanation of the role played by the resonator in slowing down or accelerating the atoms.
Concordant Signaling Pathways Produced by Pesticide Exposure in Mice Correspond to Pathways Identified in Human Parkinson's Disease (2012)

Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most widely used pesticides. We studied mRNA expression using transcriptome sequencing (RNA-Seq) in the ventral midbrain (VMB) and striatum (STR) of PQ, PY and paraquat+maneb (MNPQ) treated mice, followed by pathway analysis. We found concordance of signaling pathways between the three pesticide models in both the VMB and STR as well as concordance in these two brain areas. The concordant signaling pathways with relevance to PD pathogenesis were e.g. axonal guidance signaling, Wnt/β-catenin signaling, as well as pathways not previously linked to PD, e.g. basal cell carcinoma, human embryonic stem cell pluripotency and role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis. Human PD pathways previously identified by expression analysis, concordant with VMB pathways identified in our study were axonal guidance signaling, Wnt/β-catenin signaling, IL-6 signaling, ephrin receptor signaling, TGF-β signaling, PPAR signaling and G-protein coupled receptor signaling. Human PD pathways concordant with the STR pathways in our study were Wnt/β-catenin signaling, axonal guidance signaling and G-protein coupled receptor signaling. Peroxisome proliferator activated receptor delta (Ppard) and G-Protein Coupled Receptors (GPCRs) were common genes in VMB and STR identified by network analysis. In conclusion, the pesticides PQ, PY and MNPQ elicit common signaling pathways in the VMB and STR in mice, which are concordant with known signaling pathways identified in human PD, suggesting that these pathways contribute to the pathogenesis of idiopathic PD. The analysis of these networks and pathways may therefore lead to improved understanding of disease pathogenesis, and potential novel therapeutic targets.
Vertical and horizontal linear growth of the maxillary and mandibular lips: a longitudinal study. (1997)

This study was designed to quantify linear changes in length and thickness for both maxillary and mandibular lips. Twenty-seven (27) untreated children were used in this study. Five serial lateral radiographs were taken from the age of 3-18 years old. Results of the study demonstrated that lips grow in length and thickness by age. Also, this growth in both dimensions is more marked in male subjects than in females.
PharmacoDB 2.0 : Improving scalability and transparency of in vitro pharmacogenomics analysis (2021)

ABSTRACT Cancer pharmacogenomics studies provide valuable insights into disease progression and associations between genomic features and drug response. PharmacoDB integrates multiple cancer pharmacogenomics datasets profiling approved and investigational drugs across cell lines from diverse tissue types. The web-application enables users to efficiently navigate across datasets, view and compare drug dose-response data for a specific drug-cell line pair. In the new version of PharmacoDB (version 2.0, https://pharmacodb.ca/ ), we present: ( i ) new datasets such as NCI-60, the Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) dataset, as well as updated data from the Genomics of Drug Sensitivity in Cancer (GDSC) and the Genentech Cell Line Screening Initiative (gCSI); ( ii ) implementation of FAIR data pipelines using ORCESTRA and PharmacoDI; ( iii ) enhancements to drug response analysis such as tissue distribution of dose-response metrics and biomarker analysis; ( iv ) improved connectivity to drug and cell line databases in the community. The web interface has been rewritten using a modern technology stack to ensure scalability and standardization to accommodate growing pharmacogenomics datasets. PharmacoDB 2.0 is a valuable tool for mining pharmacogenomics datasets, comparing and assessing drug response phenotypes of cancer models. HIGHLIGHTS PharmacoDB 2.0 includes new and updated large pharmacogenomic datasets. The data processing for PharmacoDB is made fully reproducible through the use of the ORCESTRA platform and automated data ingestion pipelines The new release contains enriched annotations for drugs and cell lines via connectivity to external databases, as well as new analytical methods for tissue-specific and pan-cancer biomarker discovery The new version of PharmacoDB incorporates a scalable and reproducible framework that can accelerate the implementation of analytical pipelines including machine learning/AI for biomarker discovery in the future
Madly in Love with Shells (2016)

The passion to collect shells arose in the Upper Palaeolithic, and at-tended all the cultural evolution of Man. The breakthrough will come in the 16th century with the beginning of the great geographical explorations: the first large shells from the South Seas and the Caribbean which came in Europe received an immediate and resounding success. Beautiful and rare, and thus highly sought af-ter, they began to enrich the collections of Naturaliain the Wunderkammern,ex-traordinary places, filled with collections of a disparate and chaotic expression of richness which arose in all courts of Europe. The mid-19thcentury is called the Golden Age of Conchology thanks to Hugh Cuming ,who began to collect shells, especially in Chile and Argentina, and after from Easter Island to Polynesia and Philippines. At his death, a huge collection of nearly 53,000 shells of 19,000 species remained, that the British Museum bought. The shell collector has an unrealizable ambition: to hold all the shells of the world. Conscious of the impossibility of realizing this dream, he often specializ-es in one group (generally a family). Today, the greatcollectors particularly ap-preciate some families of gastropods, especially the cones and cowries, whose shells are very smooth, with porcelain surfaces. Other families much sought after are volutids, olivids, terebrids, mitrids, muricids, strombids, cassids, cimatids and harpids. Bivalves arouse less interest, although thorny oysters and scallops are, perhaps, the only two families really appreciated worldwide. Recently, the interest of collectors was also directed towards the shells of molluscs living in deep waters, below 1,000 meters depth, as the pleurotomariids, primitive gastro-pods characterized by a long slit that runs through the last whorl of the shell. Even many fossil molluscs are appreciated: some ammonites arouse considerable interest and can achieve amazing prices at the auctions.
Speech coding for energy-efficient digital signal processing (2000)

Waveform coding techniques known from low bitrate communication are evaluated for their usefulness in low-power digital filtering of speech signals as used in hearing aids or mobile communication applications. Experimental results are presented to quantify potential power savings subject to statistical signal properties and operating conditions. Compared to linear PCM, the energy per basic operation can be reduced by more than 50%.
Association of HLA DQ4‐DR8 haplotype with papillary thyroid carcinomas (2006)

We have typed the largest series of patients with thyroid carcinomas reported to date, and found that DR8 and DQ4 are independent susceptibility markers for PTC.
Book search (2008)

With massive book digitization efforts underway, there is a need for developing effective book retrieval strategies. This paper explores the relative contribution of different parts of digitized and OCR'ed books towards effective retrieval. The examined parts include the entire content of books, book headings, book titles, and table of content entries. Results show that indexing the headers and titles of books is nearly as effective as indexing the entire contents of books. These results indicate that certain portions of the books, specifically titles and headers, are more valuable than other parts of books. This is akin to web search where hypertext and page titles are more valuable to index than the rest of the webpage. Also, using a combination of evidence approach provides further improved retrieval effectiveness compared to using any portion of the book in isolation.
Searching For A Single Community in a Graph (2016)

In standard graph clustering/community detection, one is interested in partitioning the graph into more densely connected subsets of nodes. In contrast, the search problem of this paper aims to only find the nodes in a single such community, the target, out of the many communities that may exist. To do so , we are given suitable side information about the target; for example, a very small number of nodes from the target are labeled as such. We consider a general yet simple notion of side information: all nodes are assumed to have random weights, with nodes in the target having higher weights on average. Given these weights and the graph, we develop a variant of the method of moments that identifies nodes in the target more reliably, and with lower computation, than generic community detection methods that do not use side information and partition the entire graph.
Application transformations for energy and performance-aware device management (2003)

Energy conservation without performance degradation is an important goal for battery-operated computers, such as laptops and handheld assistants. In this paper we determine the potential benefits of application-supported device management for optimizing energy and performance. In particular, we consider application transformations that increase device idle times and inform the operating system about the length of each upcoming period of idleness. We assess the potential energy and performance benefits of this type of application support for a laptop disk. Furthermore, we propose and evaluate a compiler framework for performing the transformations automatically for a disk device. Our experimental results demonstrate that unless applications are transformed, they cannot accrue any of the predicted benefits. In addition, they show that our compiler can produce almost the same performance and energy results that we obtain by hand-modifying applications. Overall, we find that the transformations we propose can reduce disk energy consumption from 55% to 89% with only a small degradation in performance.
A randomized placebo-controlled study on the effect of nifedipine on coronary endothelial function and plaque formation in patients with coronary artery disease: the ENCORE II study (2009)

The ENCORE II trial demonstrates in a multi-centre setting that calcium channel blockade with nifedipine for up to 2 years improves coronary endothelial function on top of statin treatment, but did not show an effect of nifedipine on plaque volume.
Data from Functional Epigenomics Identifies Genes Frequently Silenced in Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;In many cases, silencing of gene expression by CpG methylation is causally involved in carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor marker. In order to identify candidate genes for inactivation by CpG methylation in prostate cancer, the prostate cancer cell lines LNCaP, PC3, and Du-145 were treated with 5-aza-2′ deoxycytidine and trichostatin A, which leads to reversion of epigenetic silencing. By microarray analysis of 18,400 individual transcripts, several hundred genes were found to be induced when compared with cells treated with trichostatin A. Fifty re-expressed genes were selected for further analysis based on their known function, which implied a possible involvement in tumor suppression. Twelve of these genes showed a significant degree of CpG methylation in their promoters. Six genes were silenced by CpG methylation in the majority of five analyzed prostate cancer cell lines, although they displayed robust mRNA expression in normal prostate epithelial cells obtained from four different donors. In primary prostate cancer samples derived from 41 patients, the frequencies of CpG methylation detected in the promoter regions of these genes were: &lt;i&gt;GPX3&lt;/i&gt;, 93%; &lt;i&gt;SFRP1&lt;/i&gt;, 83%; &lt;i&gt;COX2&lt;/i&gt;, 78%; &lt;i&gt;DKK3&lt;/i&gt;, 68%; &lt;i&gt;GSTM1&lt;/i&gt;, 58%; and &lt;i&gt;KIP2/p57&lt;/i&gt;, 56%. Ectopic expression of SFRP1 or DKK3 resulted in decreased proliferation. The expression of DKK3 was accompanied by attenuation of the mitogen-activated protein kinase pathway. The high frequency of CpG methylation detected in the promoters of the identified genes suggests a potential causal involvement in prostate cancer and may prove useful for diagnostic purposes.&lt;/p&gt;&lt;/div&gt;
A new path loss modeling approach for in-building wireless networks (2012)

Stochastic models for path loss are most often of the form PL = A + B log(d), where A and B are empirical constants derived from data via least-squares fitting, and d is the path distance. For in-building environments, however, many investigators have noted the added effects of transmission through interior walls and floors. Here, we represent this effect by a third term, which is exponentially related to log(d), and we model its impact on path loss. The database we use is obtained using a well-validated ray-tracing tool, which we apply to single floors of four very distinct office buildings. The context is an ad hoc wireless network, wherein both the transmit and receive locations can be anywhere on the floor. The resulting model consists of the median path loss, involving three fitting constants A, B and C; and a log-normal variation about the median, with its standard deviation being a function of distance. The structure and details of the model are shown to be remarkably similar across the four distinct buildings studied.
Combination of sunitinib with anti‐tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy (2013)

Sunitinib, a protein tyrosine kinase inhibitor is the frontline therapy for renal and gastrointestinal cancers. We hypothesized that by virtue of its well documented tumor apoptosis and immune adjuvant properties, combination of Sunitinib with anti-tumor immunotherapeutics will provide synergistic inhibition of tumor growth. Our study was designed to evaluate the impact of Sunitinib on immunotherapy mediated anti-tumor immune responses and evaluate its efficacy as a combinatorial therapy with tumor targeted immunotherapeutic vaccination. Mice immunized with recombinant α-lactalbumin, a lactation protein expressed on majority of breast tumors were treated with 1 mg of Sunitinib for seven consecutive days beginning (1) concurrently, on the day of α-lactalbumin immunization or (2) sequentially, on day 9 after immunization. Ten-day lymph nodes or 21 day spleens were tested by ELISPOT assays and flow cytometry to evaluate responsiveness to α-lactalbumin immunization in presence of Sunitinib and distribution of cells involved in T cell antigen priming and proliferation in different lymphoid compartments. In addition, therapeutic efficacy of the α-lactalbumin/ Sunitinib combination was evaluated by monitoring tumor growth in the 4T1 transplanted tumor model. Our studies reveal that concurrent administration of Sunitinib with active vaccination against a targeted tumor antigen inhibits priming to the immunogen due to a drastic decrease in CD11b+CD11c+ antigen presenting cells, leading to failure of vaccination. However, sequential delivery of Sunitinib timed to avoid the priming phase of vaccination results in the desired vaccination mediated boost in immune responses.
THE EQUILIBRIUM BETWEEN CREATINE AND CREATININE, IN AQUEOUS SOLUTION. THE EFFECT OF HYDROGEN ION (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE EQUILIBRIUM BETWEEN CREATINE AND CREATININE, IN AQUEOUS SOLUTION. THE EFFECT OF HYDROGEN IONGraham Edgar and H. E. ShiverCite this: J. Am. Chem. Soc. 1925, 47, 4, 1179–1188Publication Date (Print):April 1, 1925Publication History Published online1 May 2002Published inissue 1 April 1925https://pubs.acs.org/doi/10.1021/ja01681a040https://doi.org/10.1021/ja01681a040research-articleACS PublicationsRequest reuse permissionsArticle Views442Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An interview with Bob Metcalfe (2011)

Bob Metcalfe thinks we are in a bubble, an innovation bubble, seeing that the word "innovation" is on everybody's lips. To help ensure that this bubble does not burst, he has embarked on a new career path as Professor of Innovation and Murchison Fellow of Free Enterprise at the University of Texas at Austin. This is his fifth career, building on his work as an engineer-scientist leading the invention of Ethernet in the 1970s, entrepreneur-executive and founder of 3Com in the 1980s, publisher-pundit and CEO of InfoWorld in the 1990s, and venture capitalist in the 2000s. As General Partner with Polaris Venture Partners, he has invested primarily in cleantech and currently serves on the boards of five companies: Ember, Sun Catalyx, 1366 Technologies, Infinite Power, and SiOnyx.
Characterization of an empirically-derived database of time-varying microwave channel responses (2002)

This paper reports on the gathering, processing, and categorization of empirically derived time-varying channel responses. The passband data and data collection information is provided courtesy of Applied Signal Technology (Sunnyvale, CA). It is the intent of this paper to provide the signal processing community with a database of time-varying fractionally-spaced channel responses and received sequences based on empirical measurements which can be used to test and refine existing time-varying channel models and also propose new ones.
Low Subthreshold Slope AlGaN/GaN MOS-HEMT with Spike-Annealed HfO2 Gate Dielectric (2021)

AlGaN/GaN metal-oxide semiconductor high electron mobility transistors (MOS-HEMTs) with undoped ferroelectric HfO<sub>2</sub> have been investigated. Annealing is often a critical step for improving the quality of as-deposited amorphous gate oxides. Thermal treatment of HfO<sub>2</sub> gate dielectric, however, is known to degrade the oxide/nitride interface due to the formation of Ga-containing oxide. In this work, the undoped HfO<sub>2</sub> gate dielectric was spike-annealed at 600 °C after the film was deposited by atomic layer deposition to improve the ferroelectricity without degrading the interface. As a result, the subthreshold slope of AlGaN/GaN MOS-HEMTs close to 60 mV/dec and on/off ratio>10<sup>9</sup> were achieved. These results suggest optimizing the HfO<sub>2</sub>/nitride interface can be a critical step towards a low-loss high-power switching device.
Hydrophobic-Region-Induced Transitions in Self-Assembled Peptide Nanostructures (2008)

Peptide amphiphiles readily self-assemble into a variety of nanostructures, but how molecular architectures affect the size and shape of the nanoaggregates formed is not well understood. From a combined TEM and AFM study of a series of cationic peptide surfactants AmK (m = 3, 6, and 9), we show that structural transitions (sheets, fibers/ worm-like micelles, and short rods) can be induced by increasing the length of the hydrophobic peptide region. The trend can be interpreted using the molecular packing theory developed to describe surfactant structural transitions, but the entropic gain, decreased CAC, and increased electrostatic interaction associated with increasing the peptide hydrophobic chain need to be taken into account appropriately. Our analysis indicates that the trend in structural transitions observed from AmK peptide surfactants is opposite to that obtained from conventional monovalent ionic surfactants. The outcome reflects the dominant role of hydrophobic interaction between the side chains opposed by backbone hydrogen bonding and electrostatic repulsion between lysine side chains.