gebhart/patrepeval huggingface dataset:
Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11–mediated protection of regulatory T cells (2018)

Multiple sclerosis (MS) is a human disease that results from autoimmune T cells targeting myelin protein that is expressed within the central nervous system. In MS, the number of FoxP3-expressing regulatory T cells (T<sub>regs</sub>) is reduced, which facilitates the activation of autoreactive T cells. Because aspirin (acetylsalicylic acid) is the most widely used nonsteroidal anti-inflammatory drug, we examined its immunomodulatory effect in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We found that low-dose aspirin suppressed the clinical symptoms of EAE in mouse models of both relapsing-remitting and chronic disease. Aspirin reduced the development of EAE driven by myelin basic protein (MBP)-specific T cells and the associated perivascular cuffing, inflammation, and demyelination. The effects of aspirin required the presence of CD25<sup>+</sup>FoxP3<sup>+</sup> T<sub>regs</sub> Aspirin increased the amounts of Foxp3 and interleukin-4 (IL-4) in T cells and suppressed the differentiation of naïve T cells into T helper 17 (T<sub>H</sub>17) and T<sub>H</sub>1 cells. Aspirin also increased the transcription of Il11 mediated by the transcription factor CREB, which was necessary for the generation of T<sub>regs</sub> Neutralization of IL-11 negated the effects of aspirin on T<sub>reg</sub> development and exacerbated EAE. Furthermore, we found that IL-11 alone was sufficient to maintain the percentage of FoxP3<sup>+</sup> T<sub>regs</sub> and protect mice from EAE. These results identify a previously uncharacterized mode of action of aspirin.
A model-based spectral envelope wiener filter for perceptually motivated speech enhancement (2011)

In this work, we present a model-based Wiener filter whose frequency response is optimized in the dimensionally reduced logMel domain. That is achieved by making use of a reasonably novel speech feature enhancement approach that has originally been developed in the area of speech recognition. Its combination with Wiener filtering is motivated by the fact that signal reconstruction from log-Mel features sounds very unnatural. Hence, we correct only the spectral envelope and preserve the fine spectral structure of the noisy signal. Experiments on a Wall Street Journal corpus showed a relative improvement of up to 24% relative in PESQ and 45% relative in log spectral distance (LSD), compared to Ephraim and Mallah’s log spectral amplitude estimator. Index Terms: speech enhancement, Bayesian estimation, signal reconstruction
The Solar and Interplanetary Causes of Superstorms (Minimum Dst ≤ −250 nT) During the Space Age (2019)

Abstract A comprehensive study of all superstorms (minimum Dst ≤ −250 nT) occurring during the space age (after 1957) and their interplanetary and solar causes has been performed. Most superstorms were driven solely by the sheath preceding an interplanetary coronal mass ejection (ICME) or by a combination of the sheath and an ICME magnetic cloud. Only one superstorm was driven solely by a magnetic cloud. There were two superstorms caused by “compound events” with two magnetic cloud events followed by sheaths (see erratum text at the end of this article). No superstorms in this study were induced by corotating interaction regions. For the interplanetary shocks antisunward of the ICMEs, the shock normal angles were almost all quasi‐perpendicular. Quasi‐perpendicular shocks theoretically cause greater sheath magnetic field intensities than do quasi‐parallel shocks. Larger shock normal angles statistically corresponded to greater superstorm intensities. Ninety percent of the superstorms occurred either near solar maximum or during the declining phase, 8% of the superstorms occurred during the ascending phase, and 2% of the superstorms occurred during solar minimum. Fifty‐four percent of the superstorms were associated with X‐class solar flares, 36% were associated with M‐class flares, and 5% with C‐class flares. All solar flares related to superstorms occurred in active regions, indicating the importance of active regions to superstorms. Most flares were located in the central meridian or slightly west of it as expected. Two superstorms were caused by limb flares, one on the west limb (confirmed) and the other on the east limb (unconfirmed). The confirmed event was a sheath event led by a Mach 4.1 shock.
Whisper: A wearable handset (2001)

Abstract “Whisper,” a handset that can be worn on the wrist, transmits incoming sound via bone conduction through the insertion of a finger on the hand with the device into the ear. The position of a hand touching an ear resembles the way in which a conventional handset (telephone) is used, and even when the device is operated using voice commands, people nearby will regard this as “using a telephone” and experience little discomfort. In addition, the use of bone conduction to receive calls allows for calls in noisy environments without raising the volume [under 90 dB (A) of noise, –12 dB compared to a conventional handset]. Outgoing speech is achieved through a microphone attached to the inside of the wrist. By placing the finger in the ear, feedback of the speaking voice is created, and the voice does not need to be raised even under noisy conditions, virtually eliminating discomfort to anyone nearby [under 90 dB (A) of noise, –6 dB compared to a conventional handset]. In addition to its use in a voice interface for a PDA worn on the wrist, Whisper can also be used for cellular phones and other telephone applications. © 2001 Scripta Technica, Syst Comp Jpn, 32(4): 38–47, 2001
Neonatal exposure to nicotine induces increased suseptibility to paraoxon exposure at adult age (2005)

Neonatal exposure to nicotine induces increased suseptibility to paraoxon exposure at adult age
ERK‐dependent induction of TNFα expression by the environmental contaminant benzo(a)pyrene in primary human macrophages (2005)

Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta. The present study was designed in order to determine whether TNFalpha, another cytokine acting in inflammation, may also constitute a target for these chemicals. Both TNFalpha mRNA and TNFalpha secretion levels were found to be enhanced in human BP-treated macrophages. Dioxin, a contaminant activating the aryl hydrocarbon receptor (AhR) like PAHs, was also shown to increase TNFalpha expression. BP-mediated TNFalpha induction was however not suppressed by AhR antagonists, making unlikely the involvement of the typical AhR signalling pathway. BP-exposure of macrophages did not enhance NF-kappaB DNA binding activity, but it activated the MAP kinase ERK1/2. In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages. These data likely indicate that PAHs enhance TNFalpha expression in human macrophages through an ERK-related mechanism. Such a regulation may contribute to confer pro-inflammatory properties to these widely-distributed environmental contaminants.
H.P.Blavasky의 “음”과 “색채”의 생성기원과 속성 (2010)

이 논문은 블라봐츠키의 신지학의 이론에 기초한 음과 색채의 생성 기원과 구조에 관한 연구이다. 색 채와 음들은 블라봐츠키에게 물질에 반사된 빛을 통해 생겨나는 것이 아니라 정신적인 실체들이다. 그것들은 인간과 우주의 본성을 구성하는 것으로서 정신과 물질이 하나인 공간을 분화시킴으로써 인간 과 우주의 모든 존재들을 생성시켰다. 즉 색채와 음 들은 정신과 물질이 하나이며, 태양계의 모든 것들을 만들어낸 3중성의 원리 중의 하나인 제2로고스 에서 생성되어 나온 것이다. 인간과 우주는 그에게 공간이 지니고 있는 생각이 진동을 통해 생성되어 나온 것이며, 그것들은 공간이 인간과 우주를 만들어내는 원리와 같이 3중성의 원리와 7중의 존재 구 조의 형태를 지닌다. 3중성의 원리는 에너지를 발산하는 것으로서 빛 에 해당하며, 7중의 존재 구조는 가시적으로 작용 하는 7개의 힘들로서 7개의 음계와 프리즘에 나타난 7개의 색채들을 띤다. 검은 색과 흰색은 블라봐 츠키에게 인간의 망막기관을 통해서 지상에서만 존 재하는 색이며, 인간과 우주의 모든 것들을 생성시 키고 있는 음과 색채들은 프리즘에 나타난 7개의 색채와 7음계들뿐이다. 다시 말해 검은 색은 에너지가 잠재한 것이며, 흰색은 에너지가 생성되어 나 오는 순간에 폭발적으로 나타나는 빛이다. 인간은 7개의 의식구조를 지니고 있으며, 각각 의 의식 구조들은 프리즘의 7개의 색채와 7음계에 상응한다. 또한 인간의 7개의 의식 구조들은 자연 의 존재들과 7개의 행성로고스들과 연결되어 있다. 인간의 의식 구조를 통해 인식하는 음과 색채의 성 질은 태양로고스에서 생성되어 나온 7개의 행성로고스의 음과 색채의 성질과는 다르다. 그것은 프리즘에서 보는 것처럼 7개의 음과 색채들이 동시에 생성되어 나오는 것이 아니라 하나씩 생성되어 나 오며, 인간과 7개의 행성로고스가 생성되는 과정이 다르기 때문이다. 보색 대비는 그에게 인간의 망막 기관을 통한 시각적인 대비나, 또는 심리적인 대비를 통해 작용하는 성질이 아니라 인간의 하위 의식 들이 보다 상위의 의식들로 통합되는 것을 의미한 다. 음과 색채는 블라봐츠키에게 정신과 물질이 하 나인 실체가 인간과 우주의 모든 것을 생성시키게 하는 주된 요소가 되는 것으로 인간과 우주의 본성을 이룬다. 음과 색채의 이해는 인간이 자연과 우주 와 동일한 하나의 실체라는 것을 연결하는 하나의 고리가 되며, 예술의 정신적인 원리를 이해하는 하 나의 실마리가 된다.
Product Branching in the Low Temperature Reaction of CN with Propyne by Chirped-Pulse Microwave Spectroscopy in a Uniform Supersonic Flow (2015)

A new chirped-pulse/uniform flow (CPUF) spectrometer has been developed and used to determine product branching in a multichannel reaction. With this technique, bimolecular reactions can be initiated in a cold, thermalized, high-density molecular flow and a broadband microwave spectrum acquired for all products with rotational transitions within a chosen frequency window. In this work, the CN + CH3CCH reaction was found to yield HCN via a direct H-abstraction reaction, whereas indirect addition/elimination pathways to HCCCN, CH3CCCN, and CH2CCHCN were also probed. From these observations, quantitative branching ratios were established for all products as 12(5)%, 66(4)%, 22(6)%, and 0(8)% into HCN, HCCCN, CH3CCCN, and CH2CCHCN, respectively. The values are consistent with statistical calculations based on new ab initio results at the CBS-QB3 level of theory. This work is a demonstration of CPUF as a powerful technique for quantitatively determining the branching into polyatomic products from a bimolecular reaction.
Validation and uncertainty analysis of a pre-treatment 2D dose prediction model (2017)

Independent verification of complex treatment delivery with megavolt photon beam radiotherapy (RT) has been effectively used to detect and prevent errors. This work presents the validation and uncertainty analysis of a model that predicts 2D portal dose images (PDIs) without a patient or phantom in the beam. The prediction model is based on an exponential point dose model with separable primary and secondary photon fluence components. The model includes a scatter kernel, off-axis ratio map, transmission values and penumbra kernels for beam-delimiting components. These parameters were derived through a model fitting procedure supplied with point dose and dose profile measurements of radiation fields. The model was validated against a treatment planning system (TPS; Eclipse) and radiochromic film measurements for complex clinical scenarios, including volumetric modulated arc therapy (VMAT). Confidence limits on fitted model parameters were calculated based on simulated measurements. A sensitivity analysis was performed to evaluate the effect of the parameter uncertainties on the model output. For the maximum uncertainty, the maximum deviating measurement sets were propagated through the fitting procedure and the model. The overall uncertainty was assessed using all simulated measurements. The validation of the prediction model against the TPS and the film showed a good agreement, with on average 90.8% and 90.5% of pixels passing a (2%,2 mm) global gamma analysis respectively, with a low dose threshold of 10%. The maximum and overall uncertainty of the model is dependent on the type of clinical plan used as input. The results can be used to study the robustness of the model. A model for predicting accurate 2D pre-treatment PDIs in complex RT scenarios can be used clinically and its uncertainties can be taken into account.
Molecular detection of metastatic retinoblastoma cells by reverse transcription polymerase reaction for interphotoreceptor retinoid-binding protein MRNA (2001)

RT-PCR for IRBP was a useful method for detecting metastatic retinoblastoma cells as well as for evaluating the therapeutic effects of treatment in this particular case.
Restricted Orientation Dubins Path With Application to Sailboats (2019)

This letter develops a geometrical construction of the shortest Dubins path in a discontinuous orientation-restricted environment. The method proposed here builds the shortest path from one pose to the other while avoiding a no-go zone in terms of orientation, and being constrained to move forward. Finally, an application to autonomous sailboats is then provided to validate the feasibility of the planned shortest path in a position keeping scenario.
Role of Bud3p in producing the axial budding pattern of yeast. (1995)

Yeast cells can select bud sites in either of two distinct spatial patterns. a cells and alpha cells typically bud in an axial pattern, in which both mother and daughter cells form new buds adjacent to the preceding division site. In contrast, a/alpha cells typically bud in a bipolar pattern, in which new buds can form at either pole of the cell. The BUD3 gene is specifically required for the axial pattern of budding: mutations of BUD3 (including a deletion) affect the axial pattern but not the bipolar pattern. The sequence of BUD3 predicts a product (Bud3p) of 1635 amino acids with no strong or instructive similarities to previously known proteins. However, immunofluorescence localization of Bud3p has revealed that it assembles in an apparent double ring encircling the mother-bud neck shortly after the mitotic spindle forms. The Bud3p structure at the neck persists until cytokinesis, when it splits to yield a single ring of Bud3p marking the division site on each of the two progeny cells. These single rings remain for much of the ensuing unbudded phase and then disassemble. The Bud3p rings are indistinguishable from those of the neck filament-associated proteins (Cdc3p, Cdc10p, Cdc11p, and Cdc12p), except that the latter proteins assemble before bud emergence and remain in place for the duration of the cell cycle. Upon shift of a temperature-sensitive cdc12 mutant to restrictive temperature, localization of both Bud3p and the neck filament-associated proteins is rapidly lost. In addition, a haploid cdc11 mutant loses its axial-budding pattern upon shift to restrictive temperature. Taken together, the data suggest that Bud3p and the neck filaments are linked in a cycle in which each controls the position of the other's assembly: Bud3p assembles onto the neck filaments in one cell cycle to mark the site for axial budding (including assembly of the new ring of neck filaments) in the next cell cycle. As the expression and localization of Bud3p are similar in a, alpha, and a/alpha cells, additional regulation must exist such that Bud3p restricts the position of bud formation in a and alpha cells but not in a/alpha cells.
Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR‐132 and miR‐212 (2015)

To assess the involvement of microRNAs (miRNAs) in B-cell receptor (BCR) stimulation, we first evaluated miRNA profiling following IgM cross-linking in chronic lymphocytic leukemia (CLL) cells and in normal B lymphocytes. Second, we combined miRNA and gene expression data to identify putative miRNA functional networks. miRNA profiling showed distinctive patterns of regulation after stimulation in leukemic versus normal B lymphocytes and identified a differential responsiveness to BCR engagement in CLL subgroups according to the immunoglobulin heavy chain variable region mutational status and clinical outcome. The most significantly modulated miRNAs in stimulated CLL are miR-132 and miR-212. Notably, these miRNAs appeared regulated in progressive but not in stable CLL. Accordingly, gene profiling showed a significant transcriptional response to stimulation exclusively in progressive CLL. Based on these findings, we combined miRNA and gene expression data to investigate miR-132 and miR-212 candidate interactions in this CLL subgroup. Correlation analysis pointed to a link between these miRNAs and RB/E2F and TP53 cascades with proproliferative effects, as corroborated by functional analyses. Finally, basal levels of miR-132 and miR-212 were measured in an independent cohort of 20 unstimulated CLL cases and both showed lower expression in progressive compared to stable patients, suggesting an association between the expression of these molecules and disease prognosis. Overall, our results support a model involving miR-132 and miR-212 upregulation in sustaining disease progression in CLL. These miRNAs may therefore provide new valuable strategies for therapeutic intervention.
Urban Mining of Demolition Waste. Inovative Technology fromDemolition Waste to Concrete Bricks Mixture (2016)

A comprehensive technological concept known as “From Demolition
Waste to Concrete Brick Mixture” is introduced in the paper. It
issues from urban mining of antropogenic material stocks. This
technological concept is solving the issue of construction and
demolition waste (CDW) by making it into a full-fledged fresh
and hardened concrete suitable for all types of building
activities. Further is discussed a developed innovative
technological solution for prefabrication of construction
components prepared from recycled CDW in the paper. The
proposed solution could be able to help solving some
technological issues, fine-tune the technology as well as
finalize the ideal composition of the concrete brick mixture,
which is the basis for the prefabricated construction
components.
New light scattering challenges for optical components and complex optical coatings: Modelization and metrology (2017)

International audience
Packet Transmission Scheduling Algorithm for Dense Wireless Sensor Networks with Mobile Sink (2009)

A transmission scheduling algorithm is proposed for wireless sensor networks with high node densities, where a mobile sink is responsible for collecting the information from the sensor nodes with similar observations as well as determining the best transmission strategy. The proposed optimal algorithm and the reduced complexity algorithm are based on the well known tradeoff between the energy consumption and the probability of successful packet arrival at the sink, when the sensor nodes need to share a single transmission channel at each time slot. When the algorithm is used for transmission scheduling, it is advantageous in terms of power consumption and successful packet transmission rate for networks with higher node densities. Moreover, the effect of the cost of transmission power at the sink is studied for different node densities. It is shown that as we increase the cost of power at the sink, the transmission power at the nodes is dynamically adjusted in a way that keeps the average number of transmitted packets high.
Identity based authenticated key agreement protocols from pairings (2004)

We investigate a number of issues related to identity based authenticated key agreement protocols in the Diffie-Hellman family enabled by the Weil or Tate pairings. These issues include how to make protocols efficient; to avoid key escrow by a Trust Authority (TA) who issues identity based private keys for users, and to allow users to use different TAs. We describe a few authenticated key agreement (AK) protocols and AK with key confirmation (AKC) protocols by modifying Smart's AK protocol (2002). We discuss the security of these protocols heuristically and give formal proofs of security for our AK and AKC protocols (using a security model based on the model defined in (Blake-Wilson et al., 1997)). We also prove that our AK protocol has the key compromise impersonation property. We also show that our second protocol has the TA forward secrecy property (which we define to mean that the compromise of the TA's private key will not compromise previously established session keys), and we note that this also implies that it has the perfect forward secrecy property.
Nonlinear Reflection from a Phase-Matched Liquid near the Critical Angle (1969)

A study of nonlinear reflection in third order is reported. A $Q$-switched pulse from a neodymium laser at 1.06 \ensuremath{\mu} is internally reflected from a liquid whose refractive index is tuned by the anomalous dispersion of a dye additive. The dye-liquid system is fuchsin red dissolved in hexafluoroacetone sesquihydrate. An increase of more than two orders of magnitude in the intensity of reflected third-harmonic radiation is observed near the critical angle for total internal reflection when the dye concentration is adjusted for phase matching. The experimental third-harmonic data are in good qualitative agreement with theoretical prediction. A comparison is also presented of the shift in phase expected from theory for linear and nonlinear reflection.
Cytoplasmic translocation of nuclear lysine-specific demethylase-1 (LSD1/KDM1A) in human hepatoma cells is induced by its inhibitors (2018)

ABSTRACT Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is often upregulated in many cancers, including hepatoma, and is regarded as oncoprotein. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A activity at the same IC 50 as that of the clinically used drug tranylcypromine, a verified inhibitor of KDM1A. Here, we report that these inhibitors induced cytoplasmic translocation of nuclear KDM1A in a human hepatoma-derived cell line. Immunofluorescence studies revealed cytoplasmic localization of KDM1A, 3 h after addition of GGA or tranylcypromine in HuH-7 cells. Geranylgeraniol and all- trans retinoic acid were both unable to induce translocation of nuclear KDM1A, whereas farnesoic acid showed the weak activity. Furthermore, GGA did not affect subcellular localization of another histone lysine-specific demethylase, KDM5A. This suggests that the inhibitor-induced translocation of nuclear KDM1A to the cytoplasm is specific for KDM1A. These data demonstrate for the first time that KDM1A inhibitors specifically induce the cytoplasmic translocation of nuclear KDM1A. Abbreviations ATRA all- trans retinoic acid CoREST corepressor for element 1-silencing transcription factor DIC differential interference contrast FA farnesoic acid GGOH geranylgeraniol GGA geranylgeranoic acid LSD1/KDM1A lysine-specific demethylase-1 pHH3 phospho-histone H3(Ser10) TCP trans -2-phenylcyclopropylamine
A Comparison of Fatigue Failure Responses of Old Versus Middle-Aged Lumbar Motion Segments in Simulated Flexed Lifting (2007)

Younger motion segments survive considerably longer when exposed to similar spine loading conditions that simulate repetitive lifting in neutral and flexed torso postures, primarily associated with the increased bone mineral content possessed by younger motion segments. Cycles to failure of young specimens at 22.5 degrees flexion were similar to that of older specimens at 0 degrees flexion, and survivorship of young specimens at 45 degrees flexion was similar to the older cohort at 22.5 degrees.
Duplex detection of the Mycobacterium tuberculosis complex and medically important non‐tuberculosis mycobacteria by real‐time PCR based on the rnpB gene (2016)

A duplex real-time PCR based on the rnpB gene was developed for Mycobacterium spp. The assay was specific for the Mycobacterium tuberculosis complex (MTB) and also detected all 19 tested species of non-tuberculous mycobacteria (NTM). The assay was evaluated on 404 clinical samples: 290 respiratory samples and 114 from tissue and other non-respiratory body sites. M. tuberculosis was detected by culture in 40 samples and in 30 samples by the assay. The MTB assay showed a sensitivity similar to Roche Cobas Amplicor MTB-PCR (Roche Molecular Systems, Pleasanton, CA, USA). There were only nine samples with non-tuberculous mycobacteria detected by culture. Six of them were detected by the PCR assay.