gebhart/patrepeval huggingface dataset:
Robustness oriented design tool for multilayer DTCNN applications (2002)

Abstract In this work, we present a design automation tool for the synthesis of multilayer discrete time cellular neural network (DTCNN) structures that takes into account hardware implementation constraints. In so doing, the possible implementation on a VLSI CNN chip of the solutions found is guaranteed. The algorithm is based on stochastic optimization strategies, particularly genetic algorithms. In order to guarantee correct operation of analog VLSI chips the robustness of the templates and the network complexity have been considered during the optimization process by means of the introduction of penalty functions. This strategy has the side effect of reducing the computational cost of the optimization process since it focuses on those areas of the search space that meet the implementation requirements. As a difference from previous approaches to robust template design, the problem of robustness in greyscale input applications is also considered under the assumption of an appropriate selection of the training set, that must not only define the task but also contain relevant information about the images to be processed. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Integration of a Bluetooth Based ECG System into Clothing (2004)

This article describes the methods used to integrate a Bluetooth based ECG system into a T-Shirt. Some of the components are integrated into the garment, while the flexible electronic system is removable so that the garment can be washed. Technologies that need to be improved for manufacturing smart clothes were identified.
Criteria for Protective Film Growth on Carbon Steel Rebar in a Carbonation Process (2018)

Abstract The motivation behind this research was to determine if an iron carbonate (FeCO3) layer can be effective for prevention of CO2 corrosion of steel rebars, associated with production and use of carbonated calcium silicate cement-based concrete. Laboratory scale experiments were conducted on optimizing the conditions utilized to form a protective FeCO3 layer on reinforcement steel by controlling solution chemistry, temperature, and surface condition. Subsequently, the rebar with protective layers formed under different conditions was exposed to a 3.5 wt.% NaCl solution in air, representative of an extreme service condition. The corrosion rates were assessed electrochemically using the linear polarization technique. The surface morphologies of the steel and coating were analyzed by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Iron carbonate formed on sandblasted rebar had the lowest corrosion rates (&amp;lt;0.2 mm/y) under the service condition, while the other surface conditions comprising of a mill scale had corrosion rates in excess of 0.3 mm/y. Future work will emphasize modifying the iron carbonate coating to counter its susceptibility to degradation in oxidizing environments.
Measurements of the attenuation and phase velocities in bubbly fresh and salt water (2003)

Several types of bubblers have been used to create a dense bubble cloud that fills a 44-m3 tank, wherein phase velocity and attenuation measurements have been made over a wide range of frequencies. Initial experimental results on the measurement of the phase velocity and attenuation have been previously reported [J. Acoust. Soc. Am. 112, 2269]. We present in this paper how this work has been extended with respect to the environmental parameter landscape. Paramount among these parameters are the bubble size distribution, void fraction, temperature, and surface tension. In these sets of experiments, void fractions from 0.5% to roughly 4% are investigated over a wide set of temperatures to give a much larger experimental picture of acoustic propagation through near-surface bubble clouds. Current techniques for measuring these quantities will be discussed and results presented within the context of current theories with implications on ocean acoustic experiments. Additionally, initial work using data collected using various concentrations of salt water will also be presented. [Work supported by ONR.]
Uncovering Task Based Behavioral Heterogeneities in Online Search Behavior (2016)

While a major share of prior work have considered search sessions as the focal unit of analysis for seeking behavioral insights, search tasks are emerging as a competing perspective in this space. In the current work, we quantify user search task behavior for both single- as well as multi-task search sessions and relate it to tasks and topics. Specifically, we analyze user-disposition, topic and user-interest level heterogeneities that are prevalent in search task behavior. Our results show that while search multi-tasking is a common phenomenon among the search engine users, the extent and choice of multi-tasking topics vary significantly across users. We find that not only do users have varying propensities to multi-task, they also search for distinct topics across single-task and multi-task sessions. To our knowledge, this is among the first studies to fully characterize online search tasks with a focus on user- and topic-level differences that are observable from search sessions.
Hygroelastic properties of wood fibres for composite applications (2004)

Wood pulp fibers can serve as useful reinforcement of plastics for increased stiffness. To assess the potential of various wood fibers as reinforcement, a method has been developed to determine the contribution of the fibers to the elastic properties of the composite. A micromechanical composite model and classical laminate mechanics are used to relate the elastic properties of the fibers to the elastic properties of the composite. A large variety of composites made of various wood pulp fibers in an epoxy vinyl ester matrix was manufactured. From the tensile test results of the composites, the contributing Young's moduli of the fibers in the longitudinal direction are back-calculated and summarized. One finding is that there is an optimum in fiber stiffness as a function of lignin content. It is also found that industrially pulped hardwood fibers have higher stiffness than the corresponding softwood fibers. One example is kraft-cooked Norway spruce fiber, for which a Young's modulus of 40 GPa is found. The effects of hornification, prehydrolysis, and sulfite processing are also investigated. The results indicate that mild defibration process should be used, that does not damage the cell wall structure so that the inherent high stiffness of the native fibers can be retained. It can be concluded that the proposed method works well to rank the wood fiber candidates in terms of their contribution to the composite stiffness.
The Analysis of Fuel Droplet Behavior in Mixture Formation Process of DI Diesel Engine (2002)

In mixture formation process relevant to combustion and harmful matter formation process in a DI diesel engine, the turbulence effect appears from the start of break up of fuel droplets to ignitable mixture formation process. In this study, to clarify the effect of turbulence on mixture formation process, Particle Image Velocimetry (PIV) was applied to fuel droplets for investigation of the droplets behavior. The experimental results show that : Near the spray axis, droplets velocity is the fastest, and droplets in the spray peripherally have low velocity components with various directions. Fuel droplets in spray axis are disturbed by the interaction of vortex exists in spray peripherally, then this effect cause heterogeneity of fuel spray stricture, After wall impingement, fuel droplet was dispersed by turbulence effect. And dispersion of fuel droplet with high turbulence promotes fuel vapor formation.
A 1mm<sup>2</sup> 1.3mW GSM/EDGE digital baseband receiver ASIC in 0.13 &#x00B5;m CMOS (2010)

This paper addresses complexity issues at algorithmic and architectural level of digital baseband receiver ASIC design for GSM/GPRS/EDGE, in order to reduce power and die area as desired for cellular applications. A 2.5G multi-mode architecture is implemented in 0.13 μm CMOS technology occupying 1.0 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and dissipating only 1.3 mW in fastest EDGE data transmission mode.
Effect of dosing time of angiotensin II receptor blockade titrated by self-measured blood pressure recordings on cardiorenal protection in hypertensives: the Japan Morning Surge-Target Organ Protection (J-TOP) study (2010)

In HBP-guided antihypertensive treatment in hypertensives, bedtime dosing of an ARB may be superior to awakening dosing for reducing microalbuminuria.
‘Dial up’ Photonic Integrated Circuit Filter (2022)

Photonic integrated circuits (PICs) are capable of providing advanced signal processing functions in small footprints; however, their operation is affected by fabrication tolerances in addition to dynamically changing thermal and acoustic effects. Thus, it can be difficult to tune PICs to accurately implement desired functionality, even those with a relatively small number of photonic components (e.g. 10). In this contribution, we demonstrate a ‘dial-up’ PIC filter that can accurately and reliably implement a wide range of filter functions. It uses an on-chip optical reference path, which allows the phase and amplitude of each tap in a finite impulse response (FIR) filter to be individually determined. The fractional delay of the reference path is chosen to be half the delay between the FIR filter's taps, which upon Fourier transformation enables us to uniquely identify the phase and amplitude of each tap in the FIR filter. This information is used in an independent feedback algorithm to control each tap to ensure that a desired (‘dialed-up’) response is accurately implemented. To demonstrate the flexibility of the method, we experimentally demonstrate functions of a sinc-shaped filter with a phase step, a Hilbert transform and low- and high-pass filters.
Sensitive detection of cardiac biomarkers using a magnetic microbead immunoassay (2015)

To achieve improved sensitivity in cardiac biomarker detection, a batch incubation magnetic microbead immunoassay was developed and tested on three separate human protein targets: myoglobin, heart-type fatty acid binding protein, and cardiac troponin I. A sandwich immunoassay was performed in a simple micro-centrifuge tube allowing full dispersal of the solid capture surface during incubations. Following magnetic bead capture and wash steps, samples were analyzed in the presence of a manipulated magnetic field utilizing a modified microscope slide and fluorescent inverted microscope to collect video data files. Analysis of the video data allowed for the quantitation of myoglobin, heart-type fatty acid binding protein and cardiac troponin I to levels of 360 aM, 67 fM, and 42 fM, respectively. Compared to the previous detection limit of 50 pM for myoglobin, this offers a five-fold improvement in sensitivity. This improvement in sensitivity and incorporation of additional markers, along with the small sample volumes required, suggest the potential of this platform for incorporation as a detection method in a total sample analysis device enabling multiplexed detection for the analysis of clinical samples.
Data assimilation for magnetohydrodynamics with a zero-divergence constraint on the magnetic field (2008)

We address the problem of enforcing the zero- divergence constraint in data assimilation for two-dimensional magnetohydrodynamic flow. Using a finite-volume computational model, we compare the performance of the localized unscented Kalman filter with the localized equality-constrained unscented and projected localized unscented Kalman filters, which enforce the zero-divergence constraint.
A low-power oscillator-based readout interface for medical ultrasonic sensors (2016)

This paper proposed an oscillator-based ultrasonic sensor interface that can be applied to intravascular applications. The readout circuits are validated with a capacitive micromachined ultrasonic transducer (CMUT) and a current-to-frequency chip. The CMOS CMUTs are integrated with a current amplifier on the same chip and the current-to-frequency chip provides the current-to-frequency readout interface. Relaxation oscillators with injection locking are employed to achieve low-power consumption. Also, the time-based output signal can be further digitized with a time-to-digital converter. Both chips are fabricated in a 0.35μm CMOS MEMS process technology. The CMUTs are designed with 1MHz to 4MHz cells for intravascular diagnosis applications. The current amplifier consumes 281.7 μW and the power consumption of the current-to-frequency circuits is 25.4 μW.
Aryl Pyrazoles from Photocatalytic Cycloadditions of Arenediazonium (2020)

A photocatalytic synthesis of 1,5-diaryl pyrazoles from arenediazoniums and arylcyclopropanols is reported. The reaction proceeded under mild conditions (rt, 20 min) with catalytic [Ru(bpy)<sub>3</sub>]<sup>2+</sup> under blue-light irradiation and exhibited compatibility with several functional groups (e.g., I, SF<sub>5</sub>, SO<sub>2</sub>NH<sub>2</sub>, N<sub>3</sub>, CN) and perfect levels of regiocontrol. Mechanistic studies (luminescence spectroscopy, CV, DFT, radical trapping, quantum yield determination) documented an initial oxidative quenching of the excited photocatalyst and the operation of a radical-chain mechanism.
New approaches to anticancer drug design based on the inhibition of farnesyltransferase (1998)

Mutated forms of the GTP-binding protein Ras are found in 30% of human cancers, with particularly high prevalence in colon and pancreatic carcinomas. Ras function in growth factor signaling requires post-translational farnesylation of a cysteine residue present as part of the CA1A2X carboxyl terminal tetrapeptide. The enzyme farnesyltransferase has become an important target for the design of potential new antitumor agents. The authors outline the major new approaches to inhibition of farnesyltransferase and describe how certain peptidomimetics have been shown to block oncogenic signaling and tumor growth in various animal models.
Non-linear excitation control of a synchronous generator using robust feedback linearization (1997)

The objective of this paper is to design non-linear excitation controllers for synchronous generators using robust feedback linearization. Since disturbances acting on power systems are of random nature and since the variations in the interconnection variables, the machine currents, cannot be known with certainty, such systems have to be treated as non-linear uncertain stochastic systems. To take advantage of well-developed robust linear control techniques, geometry and stochastic calculus are used to transform the non-linear system to an equivalent linear uncertain system. Simulation results of a single-machine infinite-bus system indicate that the proposed controller provides a larger stability margin than that obtained using existing linear and non-linear controllers. © 1997 John Wiley & Sons, Ltd.
Rapid Detection of Cyprinid Herpesvirus 3 in Latently Infected Koi by Recombinase Polymerase Amplification (2016)

Since the emergence of cyprinid herpesvirus 3 (CyHV-3), outbreaks have been devastating to Common Carp Cyprinus carpio and koi (a variant of Common Carp), leading to high economic losses. Current diagnostics for detecting CyHV-3 are limited in sensitivity and are further complicated by latency. Here we describe the detection of CyHV-3 by recombinase polymerase amplification (RPA). The RPA assay can detect as low as 10 copies of the CyHV-3 genome by an isothermal reaction and yields results in approximately 20 min. Using the RPA assay, the CyHV-3 genome can be detected in the total DNA of white blood cells isolated from koi latently infected with CyHV-3, while less than 10% of the latently infected koi can be detected by a real-time PCR assay in the total DNA of white blood cells. In addition, RPA products can be detected in a lateral flow device that is cheap and fast and can be used outside of the diagnostic lab. The RPA assay and lateral flow device provide for the rapid, sensitive, and specific amplification of CyHV-3 that with future modifications for field use and validation could lead to enhanced surveillance and early diagnosis of CyHV-3 in the laboratory and field. Received September 14, 2015; accepted April 9, 2016.
Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs (2021)

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as chemosensitizers for topoisomerase I poisons such as topotecan. Herein, by using thieno[2,3-b]pyridines, a class of TDP1 inhibitors, we showed that the inhibition of TDP1 can restore sensitivity to topotecan, results that are supported by TDP1 knockout cell experiments using CRISPR/Cas9. However, we also found that the restored sensitivity towards topoisomerase I inhibitors is likely regulated by multiple complementary DNA repair pathways. Our results showed that one of these pathways is likely modulated by PARP1, although it is also possible that other redundant and partially overlapping pathways may be involved in the DNA repair process. Our work thus raises the prospect of targeting multiple DNA repair pathways to increase the sensitivity to topoisomerase I inhibitors.
Reproductive functions and genetic architecture of the seminal fluid and sperm proteomes of the mosquito Aedes aegypti (2018)

Abstract The yellow fever mosquito, Aedes aegypti, transmits several viruses, including dengue, Zika, and chikungunya. Some proposed efforts to control this vector involve manipulating reproduction to suppress wild populations or replacing them with disease-resistant mosquitoes. The design of such strategies requires an intimate knowledge of reproductive processes, yet our basic understanding of reproductive genetics in this vector remains largely incomplete. To accelerate future investigations, we have comprehensively catalogued sperm and seminal fluid proteins (SFPs) transferred to females in the ejaculate using tandem mass spectrometry. By excluding female-derived proteins using an isotopic labelling approach, we identified 870 sperm proteins and 280 seminal fluid proteins. Functional composition analysis revealed parallels with known aspects of sperm biology and SFP function in other insects. To corroborate our proteome characterization, we also generated transcriptomes for testes and the male accessory glands—the primary contributors to Ae. aegypti sperm and seminal fluid, respectively. Differential gene expression of accessory glands from virgin and mated males suggests that protein translation is upregulated post-mating. Several SFP transcripts were also modulated after mating, but &gt;90% remained unchanged. Finally, a significant enrichment of SFPs was observed on chromosome 1, which harbors the male sex determining locus in this species. Our study provides a comprehensive proteomic and transcriptomic characterization of ejaculate production and composition and thus provides a foundation for future investigations of Ae. aegypti reproductive biology, from functional analysis of individual proteins to broader examination of reproductive processes.
Thermal-hydraulics and safety analysis of sectored compact reactor for lunar surface power (2012)

The liquid NaK-cooled, fast-neutron spectrum, Sectored Compact Reactor (SCoRe-N 5) concept has been developed at the Univ. of New Mexico for lunar surface power applications. It is loaded with highly enriched UN fuel pins in a triangular lattice, and nominally operates at exit and inlet coolant temperatures of 850 K and 900 K. This long-life reactor generates up to 1 MWth continuously for {>=} 20 years. To avoid a single point failure in reactor cooling, the core is divided into 6 sectors that are neutronically and thermally coupled, but hydraulically independent. This paper performs a 3-D the thermal-hydraulic analysis of SCoRe--N 5 at nominal operation temperatures and a power level of 1 MWth. In addition, the paper investigates the potential of continuing reactor operation at a lower power in the unlikely event that one sector in the core experiences a loss of coolant (LOC). Redesigning the core with a contiguous steel matrix enhances the cooling of the sector experiencing a LOC. Results show that with a core sector experiencing a LOC, SCORE-N 5 could continue operating safely at a reduced power of 166.6 kWth. (authors)
Relative Contribution of Haptic Technology to Assessment and Training in Implantology (2014)

Haptic simulator brings a real benefit in training for implant surgery. Long-term benefit and more complex exercises should be evaluated.
국내외 드론산업 동향 분석을 통한 공공분야에서의 드론 활용방안에 대한 연구 (2016)

The drone is an unmanned aerial vehicle which has no human pilot. Drones can be classified into military drones, commercial drones, and personal drones by usage. Also, drones can be classified from large-sized to nano-sized drone by size and autonomous, remote controlled drone by control type. Espec...
Pathogenesis of Atherothrombotic Brain Infarction: Role of Lipids (1993)

Atherothrombotic brain infarction (ABI) is the most common cause of strokes in the industrialized world and the primary pathology is atherosclerosis. As with coronary heart and peripheral vascular diseases, ABI appears to be provoked by abnormal cholesterol metabolism and characterized by increased proliferation of smooth muscle cells of arteries and an inflammatory response in atheromas with increased inflammatory cells including macrophages. Abnormal genes regulating cholesterol, such as those for LDL, HDL and VLDL plus those affecting vasomotor activity such as angiotensin-converting enzyme and endothelin appear to play a role. Efforts to reduce serum cholesterol, as for the prevention of coronary disease, are a reasonable approach to minimize ABIs.
Structure-unknown non-linear dynamic systems: identification through neural networks (1992)

Explores the potential of using parallel distributed processing (neural network) approaches to identify the internal forces of structure-unknown non-linear dynamic systems typically encountered in the field of applied mechanics. The relevant characteristics of neural networks, such as the processing elements, network topology, and learning algorithms, are discussed in the context of system identification. The analogy of the neural network procedure to a qualitatively similar non-parametric identification approach, which was previously developed by the authors for handling arbitrary non-linear systems, is discussed. The utility of the neural network approach is demonstrated by application to several illustrative problems.