gebhart/patrepeval huggingface dataset:
Sleep Deprivation and Neurological Disorders (2020)

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like <i>α</i>-synuclein, amyloid-<i>β</i>, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended.
Laboratory characteristics of an attenuated influenza type A (H3N2) virus (‘Alice’ strain) (1976)

The Alice strain of live attenuated influenza virus was obtained by selection of a gamma inhibitor-resistant strain from a virus recombinant between A/PR/8/34 (HON1) and A/England/42/72 (H3N2). Its behaviour in vitro and in vivo was studied. Three marker systems were investigated: resistance to serum inhibitors, growth capacity at high temperature and low sensitivity to amantadine hydrochloride. In ferrets the strain was found to be attenuated and immunogenic. Passages in man, animals and eggs have not affected its resistance to gamma inhibitors.
Closed-loop Adaptive and Stochastic Prefetch Mechanism for Data Array (2014)

Projet ANR Persyval
High-gain, self-steering antenna system, engineering model Design review report (1966)

Engineering model design of high gain self- steering antenna array for satellite communication applications
Understanding Mental Ill-health as Psychosocial Disability (2019)

Psychosocial disability involves actual or perceived impairment due to a diversity of mental, emotional, or cognitive experiences. While assistive technology for psychosocial disabilities has been understudied in communities such as ASSETS, advances in computing have opened up a number of new avenues for assisting those with psychosocial disabilities beyond the clinic. However, these tools continue to emerge primarily within the framework of "treatment," emphasizing resolution or improvement of mental health symptoms. This work considers what it means to adopt a social model lens from disability studies and incorporate the expertise of assistive technology researchers in relation to mental health. Our investigation draws on interviews conducted with 18 individuals who have complex health needs that include mental health symptoms. This work highlights the potential role for assistive technology in supporting psychosocial disability outside of a clinical or medical framework.
Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b (2001)

The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b. These genes display a complex expression pattern with constitutive expression in the epithelia of oral mucosa, hair follicles, and nail beds. We generated mice deficient for both genes through embryonic stem cell technology. The majority of MK6a/b-/- mice die of starvation within the first two weeks of life. This is due to a localized disintegration of the dorsal tongue epithelium, which results in the build up of a plaque of cell debris that severely impairs feeding. However, approximately 25% of MK6a/b-/- mice survive to adulthood. Remarkably, the surviving MK6a/b-/- mice have normal hair and nails. To our surprise, we discovered MK6 staining both in the hair follicle and the nail bed of MK6a/b-/- mice, indicating the presence of a third MK6 gene. We cloned this previously unknown murine keratin gene and found it to be highly homologous to human K6hf, which is expressed in hair follicles. We therefore termed this gene MK6 hair follicle (MK6hf). The presence of MK6hf in the MK6a/b-/- follicles and nails offers an explanation for the absence of hair and nail defects in MK6a/b-/- animals.
Antibody Response to Pneumococcal Capsular Polysaccharide Vaccine in the Elderly (1996)

Antibody response to 23-valent pneumococcal vaccine was assessed in 350 subjects (131 men, 219 women) aged 65-91 years. IgG antibodies to pneumococcal serotypes 4, 6B, 9V, 14, 19F, and 23F were measured by EIA after blocking of antibodies to cell wall polysaccharide. Antibody concentrations in both pre- and postvaccination sera (mean interval, 35 days) were higher in elderly men than women; in the women, the concentrations decreased significantly with increasing age, but not in the men. Antibody fold increases were good in the elderly, including those > or = 85 years old. The overall percentage of the elderly with antibody concentrations > 1 microgram/mL to the 6 antigens increased by vaccination from 61% to 87%, but in the women > or = 85 years old, only to 75%. Antibody response to 23-valent pneumococcal vaccine was satisfactory in the elderly.
Using Computer Reverse Projection Photogrammetry to Analyze an Animation (1999)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Computer reverse projection photogrammetry (CRPP) is a technique of using computer software to obtain information from images. Use of this process can facilitate the analysis of a computer animation that depicts the reconstruction of an accident. This paper defines several digital image analysis techniques with a focus on CRPP and illustrates methods of employing their procedures. Specific aspects of animation validation and a description of the information needed to accurately complete an analysis also are described. In addition to discussing specific types of animation validation, the computer software and hardware required to perform analyses for a variety of platforms are mentioned.&lt;/div&gt;&lt;/div&gt;
A Public Health Communication Intervention Using Edutainment and Communication Technology to Promote Safer Sex among Heterosexual Men Patronizing Entertainment Establishments (2019)

It is a challenge to reach out, develop and implement a communication intervention for heterosexual men (HSM) patronizing entertainment establishments (EEs) to promote safer sex. We described the theoretical basis and process from assessment to implementation where edutainment (talk shows) and communication technology (interactive web portal) was implemented. A female comedian hosted the talk shows. The portal contained an HIV risk profile calculator with individually tailored strategies to lower risk; two videos on real-life stories of unsafe sex and exit strategies to avoid casual or paid sex; as well as online support. We integrated edutainment, social cognitive theory (SCT) and the elaboration likelihood model (ELM). Edutainment techniques like humor through jokes, fun through games, and narrative persuasion through real-life accounts were applied. The SCT focused on modifying attitudes and social norm on sexual well-being, increasing self-perceived HIV/STI risk as well as building self-efficacy and skills in condom use. We applied the ELM to guide communication strategies and message development. For peripheral processing, we used cues like comedian delivery and charisma. For central processing, we focused on argument framing, issue involvement, argument quality, and modeling. The intervention was effective in promoting condom use with casual partners among the target group in Singapore.
Image-based in vivo assessment of targeting accuracy of stereotactic brain surgery in experimental rodent models (2016)

Stereotactic neurosurgery is used in pre-clinical research of neurological and psychiatric disorders in experimental rat and mouse models to engraft a needle or electrode at a pre-defined location in the brain. However, inaccurate targeting may confound the results of such experiments. In contrast to the clinical practice, inaccurate targeting in rodents remains usually unnoticed until assessed by ex vivo end-point histology. We here propose a workflow for in vivo assessment of stereotactic targeting accuracy in small animal studies based on multi-modal post-operative imaging. The surgical trajectory in each individual animal is reconstructed in 3D from the physical implant imaged in post-operative CT and/or its trace as visible in post-operative MRI. By co-registering post-operative images of individual animals to a common stereotaxic template, targeting accuracy is quantified. Two commonly used neuromodulation regions were used as targets. Target localization errors showed not only variability, but also inaccuracy in targeting. Only about 30% of electrodes were within the subnucleus structure that was targeted and a-specific adverse effects were also noted. Shifting from invasive/subjective 2D histology towards objective in vivo 3D imaging-based assessment of targeting accuracy may benefit a more effective use of the experimental data by excluding off-target cases early in the study.
Estimating Genome-Wide Copy Number Using Allele-Specific Mixture Models (2008)

Genomic changes such as copy number alterations are one of the major underlying causes of human phenotypic variation among normal and disease subjects. Array comparative genomic hybridization (CGH) technology was developed to detect copy number changes in a high-throughput fashion. However, this technology provides only a >30-kb resolution, which limits the ability to detect copy number alterations spanning small regions. Higher resolution technologies such as single nucleotide polymorphism (SNP) microarrays allow detection of copy number alterations at least as small as several thousand base pairs. Unfortunately, strong probe effects and variation introduced by sample preparation procedures have made single-point copy number estimates too imprecise to be useful. Various groups have proposed statistical procedures that pool data from neighboring locations to successfully improve precision. However, these procedure need to average across relatively large regions to work effectively, thus greatly reducing resolution. Recently, regression-type models that account for probe effects have been proposed and appear to improve accuracy as well as precision. In this paper, we propose a mixture model solution, specifically designed for single-point estimation, that provides various advantages over the existing methodology. We use a 314-sample database, to motivate and fit models for the conditional distribution of the observed intensities given allele-specific copy number. We can then compute posterior probabilities that provide a useful prediction rule as well as a confidence measure for each call. Software to implement this procedure will be available in the Bioconductor oligo package (www.bioconductor.org).
Fecal Elastase in Preterm Infants to Predict Growth Outcomes (2022)

Fecal ELA1 in preterm infants fed exclusive human milk diet increases with postnatal age. Although pancreatic function in preterm infants may serve as a biological contributor to early postnatal growth failure, additional studies using fecal ELA1 as a predictive biomarker for growth failure are needed in larger cohorts.
Tectonic history of the Osbourn spreading center and dynamic subsidence of the Congo basin (2009)

This is a thesis in two parts. First is the presentation of a new technique by which it is possible to constrain tectonic models of oceanic regions which are devoid of magnetic reversal anomalies. I applied this technique to the Osbourn region of the Southwest Pacific and determined the tectonic history of the Cretaceous Osbourn spreading center. The results of this analysis showed that the Osbourn Trough, although an extinct spreading center, was not part of the Cretaceous Pacific-Phoenix spreading center. The second part of this thesis involves study of the cratonic Congo sedimentary basin. I created instantaneous dynamic models of the Congo basin that are strongly constrained by observation and which demonstrate that the most recent subsidence event of the basin has a mantle dynamic origin. These models constrain the density structure of the upper mantle beneath the Congo. In addition, I examined geologic data that constrain the time-dependent history of the Congo basin in an attempt to determine the subsidence mechanism of cratonic sedimentary basins.
Chopper (2012)

3D printing technology is rapidly maturing and becoming ubiquitous. One of the remaining obstacles to wide-scale adoption is that the object to be printed must fit into the working volume of the 3D printer. We propose a framework, called Chopper, to decompose a large 3D object into smaller parts so that each part fits into the printing volume. These parts can then be assembled to form the original object. We formulate a number of desirable criteria for the partition, including assemblability, having few components, unobtrusiveness of the seams, and structural soundness. Chopper optimizes these criteria and generates a partition either automatically or with user guidance. Our prototype outputs the final decomposed parts with customized connectors on the interfaces. We demonstrate the effectiveness of Chopper on a variety of non-trivial real-world objects.
Damned if you monitor, damned if you don’t: medical malpractice and intraoperative neuromonitoring for spinal surgery (2020)

The use and interpretation of intraoperative neuromonitoring findings can be the basis for a medical malpractice litigation. Spine surgeons can face malpractice risks by not monitoring when required by the standard of care and by interpreting or reacting to neuromonitoring findings inappropriately.
Modification des ingestions protéiques par la séance d’hémodialyse : une piste pour lutter contre la dénutrition (2015)

Modification des ingestions protéiques par la séance d’hémodialyse : une piste pour lutter contre la dénutrition. 17. réunion commune - société de néphrologie - société francophone de dialyse
Stress Sensitivity of PMOSFET Under High Mechanical Stress (2006)

Using PMOSFETs with a range of built-in process induced stress and four-point bending characterization, we present evidence that the stress response of PMOSFETs increases with channel stress. A novel method incorporating the characterization data with channel stress simulation has been developed which shows excellent agreement between our prediction and measured transistor performance data for nitride etch stop layer splits. Our analysis indicates that PMOSFETs will continue to show increasingly effective performance enhancement at higher channel stress.
Growth properties, differentiation capacity and oncogene expression in metastatic and nonmetastatic Friend leukemia cell variants. (1991)

The aims of this study were: (1) to characterize the biologic properties of the WGA-resistant (WR) Friend leukemia cells (FLC) as compared to the original nonmetastatic or highly metastatic FLC; (2) to investigate the possible correlations between the expression of some oncogenes (i.e., c-myc, H-ras and K-ras) and the in vitro and in vivo behavior of FLC. The tumorigenic behavior of the different FLC types strongly depended on the site of tumor injection. Both WR FLC and in vitro passaged FLC did not grow as ascites (when injected intraperitoneally) and developed large solid tumors (when injected subcutaneously), without forming any spleen or liver metastasis. In contrast, in vivo passaged FLC rapidly formed hemorrhagic ascites when injected intraperitoneally; the subcutaneous injection of these cells resulted in the development of solid tumors, which were smaller than the other FLC tumors, but capable of metastasizing to the liver and to the spleen. No significant differences were observed in the in vitro growth characteristics and cell cycle parameters among the different FLC types under various experimental conditions (i.e., FCS concentration or cell seeding densities). Similarly to the metastatic in vivo passaged parental cells, WR FLC exhibited a much lower erythroid differentiation after in vitro addition of either dimethyl sulfoxide or hexamethylene bisacetamide than the in vitro passaged FLC. High levels of c-myc oncogene mRNA were expressed in all FLC variants; no major variations in the c-myc expression were observed in FLC cultivated in medium supplemented with different FCS concentrations and/or seeded at various cell densities. In addition, no changes in the expression of H-ras or K-ras were observed between the different FLC types.
A Novel Electrogenic Amino Acid Transporter Is Activated by K+ or Na+, Is Alkaline pH-dependent, and Is Cl−-independent (2000)

A new eukaryotic nutrient amino acid transporter has been cloned from an epithelium that is exposed to high voltages and alkaline pH. The full-length cDNA encoding this novel CAATCH1 (cation-anion-activated Amino acid transporter/channel) was isolated using a polymerase chain reaction-based strategy, and its expression product in Xenopus oocytes displayed a combination of several unique, unanticipated functional properties. CAATCH1 electrophysiological properties resembled those of Na(+),Cl(-)-coupled neurotransmitter amine transporters, although CAATCH1 was cloned from a gut absorptive epithelium rather than from an excitable tissue. Amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline pH-dependent CAATCH1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (DAT, SERT, NET) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. These I-V relationships indicated a combination of substrate-associated carrier current plus an independent CAATCH1-associated leakage current that could be blocked by certain amino acids. However, unlike all structurally related proteins, CAATCH1 activity is absolutely independent of Cl(-). Unlike related KAAT1, CAATCH1 possesses a methionine-inhibitable constitutive leakage current and is able to switch its narrow substrate selectivity, preferring threonine in the presence of K(+) but preferring proline in the presence of Na(+).
Supplementary Data from Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages (2023)

&lt;p&gt;Supplementary data, including supplementary figures with figure legends below&lt;/p&gt;
In situ passivation and blue luminescence of silicon clusters using a cluster beam/H2O codeposition production method (2009)

Si clusters are produced in a gas aggregation source and fly through ultrahigh vacuum onto a cold target where they are codeposited with water vapor. Melting of the ice yields immediately a suspension of nanoparticles that emits intense, nondegrading luminescence in the blue wavelength range. Spectroscopic analysis reveals a Si/SiO core-shell structure where the luminescence stems from oxygen deficient defects. The main advantage of our production method is that it yields the luminescent Si nanoparticles in one step.
Separation of neutral proteins on ion-exchange resins (1955)

I.C.I. Fellow,
Understanding the Force-vs-Distance Profiles of Terminally Attached Poly(N-isopropyl acrylamide) Thin Films (2009)

In this work, we examine the interaction between thin films composed of terminally anchored poly(N-isopropyl acrylamide) (PNIPAAm) immersed in water and test surfaces. Understanding this force of interaction can be important when using PNIPAAm surfaces in biotechnological applications such as biological cell cultures. The two novel contributions that are presented here are (1) the use of a recently developed self-consistent field (SCF) theory to predict the force-vs-distance profiles, and (2) the use of a modified polymer scaling theory to estimate the wet film thickness from experimental force-vs-distance profiles. SCF theory was employed to model the equilibrium structure of the uncompressed PNIPAAm chains, and the force between a compressed polymer film and a test surface as a function of wall separation distance. The parameters that were varied include temperature, polymer molecular weight, and surface coverage. The force-vs-distance profiles obtained at low and high temperatures with the SCF theory were in qualitative agreement with the experimentally measured profiles reported in the literature. We also compared the results of our SCF theory to the Alexander de Gennes scaling theory and found agreement at large separation distance. We also propose a method to estimate the wet polymer film thickness from a force-vs-distance profile obtained from an atomic force microscope measurement. The main novelties of this approach are that we employed a density functional theory corrected version of scaling theory proposed by McCoy et al. [McCoy, J. D.; Curro, J. G. J. Chem. Phys. 2005, 122, 164905], and we provide equations to account for various geometries of AFM tips.
Electromagnetic Optics of Thin-Film Coatings (2020)

Three experts in the field of thin-film optics present a detailed and self-contained theoretical study of planar multilayers and how they can be effectively exploited in both traditional and modern applications. Starting with a discussion of the relevant electromagnetic optics, the fundamental optical properties of multilayers are introduced using an electromagnetic approach based on a direct solving of Maxwell's equations by Fourier transforms. This powerful approach is illustrated through the comprehensive description of two of the most important phenomena in multilayers, i.e. giant field enhancement in dielectric stacks and light scattering from thin-film optical filters. The same approach is extended to the description of the operation of planar microcavities and the balance of energy between radiated and trapped light. This book will be valuable to researchers, engineers and graduate students with interests in nanophotonics, optical telecommunications, observational astronomy and gravitational wave detection.
Foreign entry strategies: strategic adaptation to various facets of the institutional environments (2009)

A comprehensive model of foreign entry strategies by multinational enterprises (MNEs) is developed in this paper, and a theory is proposed on how the entry strategy is likely to be determined in the interface between internal and external pressures for both conformity and legitimacy. In contrast to a selection rationale, an adaptation argument is developed, through which we enhance our understanding of the various facets of the institutional environment and the constraints MNEs encounter in their internationalization strategies.
Using Trade-off Information in Attributes' Investing (1998)

The paper describes the use of trade-off information to create effective stock portfolio characterized by the desired values of selected stock attributes. The basic notions behind such a process of portfolio creation are discussed and related to multi attribute analysis which is done by evaluating compensations among the attributes' values. A framework to construct a portfolio using only compensatory information is presented and applied to the analysis of stocks traded on the Toronto Stock Exchange.