gebhart/patrepeval huggingface dataset:
Arrays of lipid bilayers and liposomes on patterned polyelectrolyte templates (2006)

This paper presents novel methods to produce arrays of lipid bilayers and liposomes on patterned polyelectrolyte multilayers. We created the arrays by exposing patterns of poly(dimethyldiallylammonium chloride) (PDAC), polyethylene glycol (m-dPEG) acid, and poly(allylamine hydrochloride) (PAH) on polyelectrolyte multilayers (PEMs) to liposomes of various compositions. The resulting interfaces were characterized by total internal reflection fluorescence microscopy (TIRFM), fluorescence recovery after pattern photobleaching (FRAPP), quartz crystal microbalance (QCM), and fluorescence microscopy. Liposomes composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phosphate (monosodium salt) (DOPA) were found to preferentially adsorb on PDAC and PAH surfaces. On the other hand, liposome adsorption on sulfonated poly(styrene) (SPS) surfaces was minimal, due to electrostatic repulsion between the negatively charged liposomes and the SPS-coated surface. Surfaces coated with m-dPEG acid were also found to resist liposome adsorption. We exploited these results to create arrays of lipid bilayers by exposing PDAC, PAH and m-dPEG patterned substrates to DOPA/DOPC vesicles of various compositions. The patterned substrates were created by stamping PDAC (or PAH) on SPS-topped multilayers, and m-dPEG acid on PDAC-topped multilayers, respectively. This technique can be used to produce functional biomimetic interfaces for potential applications in biosensors and biocatalysis, for creating arrays that could be used for high-throughput screening of compounds that interact with cell membranes, and for probing, and possibly controlling, interactions between living cells and synthetic membranes.
Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model (2022)

Marstacimab alone or with bypassing agents increased hemostasis in hemophilia plasma without generating excessive thrombin. The hemostatic activity of marstacimab plus aPCC was confirmed in hemophilia A mice.
Effects of development of host immunity on the biodistribution of xenogeneic MHC non-restricted cytotoxic T cells: implications for adoptive cell therapy of cancer. (1999)

The human MHC non-restricted cytotoxic T cell line TALL-104 has potent anti-tumor effects in dogs with spontaneous tumors. This study was designed to examine the effects of the development of host immune responses on the baseline organ distribution of TALL-104 cells in healthy dogs. 111In-oxine labeled TALL-104 cells (107 cells/kg) were infused systemically in three dogs, either on day 1, 3, or 5 of a 5-day injection cycle; two dogs received two more injections of the labeled cells at monthly intervals, whereas the third dog received free 111In-oxine, 3 months after the first 5-day infusion. Analysis of blood and plasma cell clearances and imaging studies indicated a progressively faster clearance of the cells from the blood and organs after multiple daily injections as well as at the time of each monthly boost when host immune responses against the xenogeneic cells had developed. These findings have important therapeutic implications for the design of effective TALL-104 cell administration schedules in clinical trials.
Reduced chemistry descriptions for ignition and detonation of higher hydrocarbons (2002)

Introduction The chemistry of ignition and detonation of higher hydrocarbons and especially propane in oxygen-diluent mixtures is studied for post-shock temperatures between 1000 K and 2500 K, pressures between 1 to 100 bar and equivalence ratios between 0.5 to 2.0. A detailed mechanism that had been previously developed is extended for ignition and detonation by including 26 additional propane-related reactions. The resulting detailed mechanism of 174 reactions and 36 species for propane predicts autoignition times that are in good agreement with data from shock-tube experiments. A short mechanism of 34 reactions is identified by sequentially removing reactions that do not influence the ignition chemistry of propane. Steady-state species are identified for both high and low-temperature conditions. Application of steady-state approximations leads to reduced chemistry descriptions, which describe the distinct stages in the ignition chemistry of propane. These reduced mechanisms form the basis for further simplified descriptions that can be used in computational studies on multidimensional ignition and detonation. Numerical and theoretical studies on detonation of fuels like propane (CaHs) and JP-10 are in need of realistic chemical-kinetic descriptions that retain the essential features of the detailed descriptions. Reduced chemistry descriptions have been previously developed successfully for a number of lower hydrocarbon fuels. Recently the ignition behavior of n-heptane has been studied for high, low and intermediate temperature regimes as well. In the present work, the chemistry of ignition of propane in oxygendiluent mixtures is studied with emphasis on developing systematically reduced mechanisms for use in detonation studies. The overall activation energy and ignition times for propane are similar to those of JP-10, which is a suitable fuel for use in Pulse Detonation Engines. For this reason, propane has been used as a model fuel for several numerical and experimental studies on detonations. In addition, the ignition mechanism for propane is found to be similar to that of other higher hydrocarbons and different from that of the lower hydrocarbons addressed previously. * Current affiliation: GE Corporate Research and Development Center, NY 12309 ^ Corresponding author American Institute of Aeronautics and Astronautics (c)2002 American Institute of Aeronautics & Astronautics or Published with Permission of Author(s) and/or Author(s)' Sponsoring Organization.
Reference Signal Design for Flexible MIMO Operation in LTE-Advanced Downlink (2010)

In this paper we address the issue of demodulation reference signal design for LTE-Advanced downlink. Practical systems such as LTE-Advanced should operate in highly time-frequency selective environment. Hence, they impose a very tight trade-off between the radio resources available for reference signals used for channel estimation and spectral efficiency targets to be met. As an additional constraint, LTE-Advanced brings to real deployments state-of-the-art multi-antenna technologies such as multi-user MIMO and cooperative MIMO. The difficult radio environment and the multitude of different multi-antenna techniques set very high challenges to the reference signal design. In this paper we discuss selected issues of realistic demodulation reference signal design for LTE-Advanced. We highlight the trade-offs that are needed for enabling advanced MIMO technologies, while at the same time allowing low complexity channel estimation at the receiver side without increasing related signaling overhead. Based on the analysis we propose a certain reference signal design for LTE-Advanced that fulfills all the required design criteria.
Block-based compressive sampling for digital pixel sensor array (2010)

In this paper, a block-based online compressive sampling scheme for digital pixel sensor (DPS) is proposed. The overall sensor array is divided into blocks whereby one randomly selected pixel within each block is sampled using a random access control circuit. The latter is performed using off-array horizontal and vertical control logic. The random access addresses are updated during readout phase using low complexity logic operations performed on the readout pixel values. A sparse matrix, consisting of all the sampled pixel values, is buildup to reconstruct the image by solving the l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -norm minimization as the linear programming problem in the framework of Convex Optimization. The proposed system features reduced on-chip compression processing complexity and significant reduced memory requirement. System level simulation results show that a 25dB reconstructed image quality in terms of PSNR is achieved enabling a compression ratio of 4. In addition, a pixel-level memory requirement reduction of 75% is achieved when compared to a standard PWM DPS architecture.
Effects of mineral salts on forage seeds germination (2018)

The objective of this study was to evaluate seed germination of three different forage species subjected to saline stress. The seeds remained in salt for 0 to 24 h and were then deposited in field beds. After 15 days, the germination was evaluated from its emergence. The effect of NaCl on germination was evaluated for the following treatments: a) 0 h (control); b) permanence in NaCl for 6 h; c) permanence in NaCl for 12 h; d) permanence in NaCl for 18 h; e) permanence in NaCl for 24 h. Five treatments with five replicates were applied to each forage species. The experimental design was completely randomized where the treatment was represented by the moment of observation, being 0, 6, 12, 18 and 24 h. For this experiment, differences (P &lt; 0.05) were observed among treatments for the three forage species. For black oat and calopogonium, the different moments of salt stress in which their seeds were treated did not affect their germination. Perennial soybean suffered a decrease in germination as its seeds were exposed to salt for 6 h resulting in only 1.6% of germinated seeds. Saline stress did not affect the germination of black oat and calopogonium, both had higher values as compared to perennial soybean, in exposure time of 24 h. It is concluded that in the experimental conditions, black oat and calopogonium can be mixed with the mineral salt, without negative effect on its viability. Key words: Seed dormancy, saline stress, mineral salt, environmental sustainability.
The efficacy of ultrasonic irrigation to remove artificially placed dentine debris from different‐sized simulated plastic root canals (2004)

In simulated plastic root canals, the diameter and taper of root canal influenced the effectiveness of ultrasonic irrigation to remove artificially placed dentine debris.
Antiangiogenic therapy and immune checkpoint blockade go hand in hand (2017)

Immune checkpoint blockade (ICB) therapies, such as the ones targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) or programmed cell death protein 1 (PD-1), have displayed durable clinical responses in various cancers and are now approved by the FDA for a growing list of cancer types (1). Although these new immunotherapies have had a notable effect on cancer treatment, multiple mechanisms of immune resistance have been described. Tumors considered immunologically “cold”, with reduced or even absent infiltration of T-cells, are a major hurdle in the cancer immunotherapy field, and strategies to overcome this resistance mechanism constitute an unmet need. Recent efforts have focused on combining this immunotherapy approach with other therapies to maximize its potential. However, the candidate for these combination therapies are numerous and therefore the need for mechanism based and rationally designed therapies is needed.
Coal Preparation Technology: Status and Development in China (2015)

The rapid growth of coal production is supporting China's economic development. This paper discusses significant developments of coal preparation industry in China. The development direction of low-quality coal resources is also described, including the comprehensive utilization of resources and green coal preparation. Coal preparation may shift from the simple separation and production of highquality products to a comprehensive utilization of associated resources and lowquality coal. Green coal preparation is a new concept and involves a highly efficient coal preparation method based on the water cycle and comprehensive utilization of resources. This paper also describes a technology that transforms coal (mineral) resources (including natural, secondary, and artificial resources) into useful products (including raw materials and fuel) by separation, extraction, and processing for an eco-friendly approach to using secondary resources.
Metal finishing challenges in the fabrication of radio telescopes (1986)

The Raman Research Institute, Bangalore, India, has set up two radio telescopes (10. 4 m and 1. 5 m) for millimeter wave radio astronomy. Fabrication of these telescopes posed several challenges in metal finishing. Developing a coating for improving the wear resistance of the cutter used for dry machining of aluminium honeycomb, electroforming of corrugated horn with integral flange and circular-to-rectangular transition piece, and copper plating the 1. 5m FRP dish are some of the interesting problems that arose during the fabrication. The solutions developed for these problems are described.
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program (2016)

A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using automated ligand identification system-affinity selection (ALIS-AS) methodology, metabolites in the incubation mixture were prioritized by their binding affinities to the FIXa protein. Microgram quantities of the metabolites of interest were then isolated through microisolation analytical capabilities, and structurally characterized using MicroCryoProbe heteronuclear 2D NMR techniques. The isolated metabolites recovered from the NMR experiments were then submitted directly to an in vitro FIXa enzymatic assay. The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS assay was completely consistent with the enzymatic assay results. This work showcases an innovative and efficient approach to uncover structure-activity relationships (SARs) and guide drug design via microisolation-structural characterization and ALIS capabilities.
Distributed power allocation strategy in shallow water acoustic interference channels (2016)

Due to the absence of spectrum regulation and limited bandwidth, underwater acoustic (UA) systems are prone to interfere with each other. To limit this interference, a decentralized power allocation strategy is proposed for multiple OFDM UA links sharing the same physical resource. These links are supposed to be noncooperative and aim at selfishly maximizing their own information rate. Each link is assumed to only know the statistics of its channel and the overall noise plus interference power spectral density. A game-theoretic formulation, which explicitly takes into account the random time-varying nature of the underwater acoustic channel as well as the low speed of sound, is derived. Numerical simulations show the strong benefit of the proposed approach in highly interfering channels.
Direct-manipulation user interfaces (1990)

A direct-manipulation user interface presents on a user's display the visual representation of the objects of an application program and a menu of the generic operations that can be performed on any of them. Instead of using a, frequently hard-to-learn, command language to describe operations on hidden objects, the user handles them directly on a graphic display. The displayed objects are active : they are modified at each action, they are not simply the static output resulting from a command execution.\nWe have developed direct-manipulation user interfaces for various applications, including\nphysics data acquisition control, charged particles beam transport design, graphical data presentation, physics spectra and medical images analysis.\nObject-oriented programming has been found to be a natural approach to design direct-manipulation user interfaces.\nThe C++ object-oriented language has been selected for its availability and efficiency to implement such interfaces on top of the industry standards X Window System for Unix Workstations. The objects have been clearly separated into subjects and views. The subjects are the abstract models of the application data and the views are their displayed representation. The subjects are built from NIH, a general purpose C++ object library\ndesigned by Keith Gorlen of the US National Institute of Health. The views are made of the structured graphics of InterViews. Principally used to implement the user interface, InterViews is a C++ X Window Toolkit developed by Mark Linton of Stanford University. Following the rules of the DEC X User Interface Style Guide, we easily reused InterViews and NIH to implement menus and dialogue boxes.\nWe will discuss the architecture of the applications, the advantages and the limitations of the tools and their impact on our implementation.
IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis (2018)

Targeting IL-1 and its downstream IL-17 activity may be a novel treatment strategy for inhibiting inflammation and tissue fibrosis in SSc.
Effects of composition modulation on the luminescence properties of Eu3+ doped Li1−xAgxLu(MoO4)2 solid-solution phosphors (2015)

Double molybdate scheelite-type solid-solution phosphors Li1-xAgxLu1-y(MoO4)2:yEu(3+) were synthesized by the solid state reaction method, and their crystal structures and luminescence properties were investigated in detail. The composition modulation and structural evolution of this series of samples were studied and the selected AgEu(MoO4)2, AgLu(MoO4)2, LiLu(MoO4)2 and LiEu(MoO4)2 phases were analyzed based on the Rietveld refinement. Depending on the variation of the Li/Ag ratio in Li1-xAgxLu1-y(MoO4)2:yEu(3+) phosphors, the difference in the luminescence properties of Li1-xAgxLu1-y(MoO4)2:yEu(3+) phosphors was ascribed to two factors, one reason could be assigned to the coupling effect and the nonradiative transition between the energy levels of LixAg1-xLu(MoO4)2 matrices and the activator Eu(3+), another could be due to the near ultraviolet energy absorption and transmission efficiency between the charge-transfer (CT) band of O(2-)-Mo(6+) and the 4f → 4f emissive transitions of Eu(3+). The ultraviolet-visible diffuse reflection spectra (UV-vis DRS) and Raman spectra analysis were also used to verify the above mechanism.
Direct Methods for Sparse Matrices (2017)

Abstract Direct Methods for Sparse Matrices, second edition, is a complete rewrite of the first edition published 30 years ago. Much has changed since that time. Problems have grown greatly in size and complexity; nearly all our examples were of order less than 5,000 in the first edition, and are often more than a million in the second edition. Computer architectures are now much more complex, requiring new ways of adapting algorithms to parallel environments with memory hierarchies. Because the area is such an important one to all of computational science and engineering, a huge amount of research has been done since the first edition, some of it by the authors. This new research is integrated into the text with a clear explanation of the underlying mathematics and algorithms. New research that is described includes new techniques for scaling and error control, new orderings, new combinatorial techniques for partitioning both symmetric and unsymmetric problems, and a detailed description of the multifrontal approach to solving systems that was pioneered by the research of the authors and colleagues. This includes a discussion of techniques for exploiting parallel architectures and new work for indefinite and unsymmetric systems.
Interactions of α2-macroglobulin and amyloid β peptide (2001)

The pathological hallmarks of Alzheimer’s disease (AD) are senile plaques and neurofibrillary tangles. A major component of senile plaque is β-amyloid peptide (Aβ) [1 2]. Several lines of evidence suggest that a progressive deposition of aggregated Aβ is an early and necessary event in AD [3-5]. Several forms of the hydrophobic Aβ, consisting of 39-43 amino acids, are generated from the amyloid precursor protein (APP) [3-5]. Synthetic Aβ spontaneously aggregates and forms amyloid-like fibril [6 7]. The aggregated Aβ is neurotoxic [8 9].
Relationship between adenylate cyclase sensitivity to follitropin and FSH receptor mRNA expression in the ovary of the lizard Podarcis sicula (2002)

In mammals, gonadal functions are regulated by two pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), that interact with gonadal membrane receptors to activate adenylate cyclase. In comparison to mammalian systems, in squamate reptiles a reduced amount of information exists on gonadotropins and their related receptors. This study is aimed at clarifying if, in the lizard Podarcis sicula, the ovarian sensitivity to FSH is correlated to the reproductive cycle and to the expression of membrane receptors involved in the hormone recognition. The results demonstrate that the ovarian adenylate cyclase responsiveness to FSH parallels ovarian functions, being maximal during the ovulatory period. The ovarian sensitivity to FSH is also related to oocyte growth and vitellogenesis. Northern blot analyses reveal that the FSH receptor mRNA is maximally expressed in vitellogenic oocytes during the reproductive period. These results suggest that, in lizard ovary, hormone activation of adenylate cyclase is mediated by de novo synthesis of receptors specifically involved in FSH recognition. In lizards treated in vivo with FSH during the pre-ovulatory period, adenylate cyclase becomes refractory to further FSH stimulation 2 hr after treatment, but sensitivity to the hormone is restored after 2 weeks. Nevertheless, while the restored level of activity never exceeds that observed during the nonreproductive period, the expression level of FSH receptor mRNAs is significantly enhanced in these animals. These results suggest that in lizard the processes that regulate ovarian growth, vitellogenesis, and ovulation are controlled by a complex network of signals including gonadotropin, FSH receptor expression, and adenylate cyclase.
Sensory peptide neurotransmitters mediating mucosal and distension evoked neural vasodilator reflexes in guinea pig ileum (2005)

The aim was to determine the role CGRP and/or tachykinins released from sensory neural mechanisms in enteric neural vasodilator pathways. These pathways project through the myenteric plexus to submucosal vasodilator neurons. Submucosal arterioles were exposed in the distal portion of an in vitro combined submucosal-myenteric guinea pig ileal preparation, and dilation was monitored with videomicroscopy. Vasodilator neural reflexes were activated by gently stroking the mucosa with a fine brush or by distending a balloon placed beneath the flat-sheet preparation in the proximal portion. Dilations evoked by mucosal stroking were inhibited 64% by the CGRP 8–37 and 37% by NK 3 (SR 142801) antagonists. When the two antagonists were combined with hexamethonium, only a small vasodilation persisted. Balloon distension-evoked vasodilations were inhibited by NK 3 antagonists (66%) but were not altered by CGRP 8–37. In preparations in which myenteric descending interneurons were directly activated by electrical stimulation, combined application of CGRP 8–37 and the NK antagonists had no effect. Stimulation of capsaicin sensitive nerves in the myenteric plexus did not activate these vasodilator reflexes. These findings suggest that mucosal-activated reflexes result from the release of CGRP and tachykinins from enteric sensory neurons. Distension-evoked responses were significantly blocked by NK 3 antagonists, suggesting that stretch activation of myenteric sensory neurons release tachykinins that activate NK 3 receptors on myenteric vasodilator pathways.