gebhart/patrepeval huggingface dataset:
De volta aos movimentos sociais? Reflexões a partir da literatura brasileira recente (2010)

In recent years, it is observed in Brazilian social sciences an apparent break with the trend of reflux in studies of social movements, from an increase in publications geared to the theme. In particular, a significant number of scientific journals recently devoted issues to this topic. These publications seem to indicate a resumption as well as a recovery of studies on social movements, and, more broadly, on the processes of organization and social mobilization. In response to this recovery, the goal of this paper is to map the theoretical and epistemological perspectives that characterize this recent literature by means of identifying the present approaches, and, eventually, those in dispute in the current field of research on social movements in Brazil. In addition, the article aims to identify the issues raised by this literature which would form the current research agenda in the field of Social Sciences. Finally, the article raises questions about some aspects of this literature, and points out the lack of issues that should be part of the research agenda.Key words: social movements, collective action, associativism, contentious politics, civil society.
Late dislocation of the capsular bag–intraocular lens–modified capsular tension ring complex after knotless transscleral suturing using 9-0 polypropylene (2020)

We report a case of late breakage of a 9-0 polypropylene transscleral suture used for fixation of a dislocated capsular bag-intraocular lens-modified capsular tension ring complex in a 52-year-old woman with Marfan syndrome. Breakage occurred despite use of a cow-hitch technique for external and internal fixation. We believe breakage was caused by the suture chafing on the sharp edges of the modified capsular tension ring eyelet. Cross-sectional analysis of Malyugin-modified capsular tension rings from two different manufacturers revealed a difference with respect to radius of curvature. Suturing intraocular implants with relatively sharp edges may cause suture breakage; further studies are needed to identify the critical parameters for the surface quality of sutured intraocular implants.
Inserting DNA with CRISPR (2019)

Inserting large DNA segments with CRISPR holds great promise for genetic engineering
Low-insertion loss phase shifter for millimeter-wave phased array antennas (2014)

This paper proposes a compact, low-loss, and low-cost phase shifter for millimeter-wave/sub-THz applications. The basic idea is to perturb the propagation constant of a high resistivity silicon image guide by high-dielectric constant barium lanthanide tetratitanates (BLT) ceramic loading. Three different BLT ceramic samples have been tested. The measured maximum phase-shift variation reaches 150° at 100 GHz with an average insertion loss of 2.85 dB and an insertion loss variation &lt;0.7 dB for a sample of a 5-mm length. The proposed phase shifter has a bandwidth from 95 to 105 GHz. A low-cost fabrication technology has been developed and used to realize this phase shifter.
User's Manual for AIMJET (1997)

http://deepblue.lib.umich.edu/bitstream/2027.42/21517/2/rl2494.0001.001.pdf
ChemInform Abstract: Reductive Alkylation of γ‐Cyano‐α,β‐unsaturated Ketones. A Modified Robinson Annulation Process to α,α‐Disubstituted‐β,γ‐unsaturated Cyclohexanone System. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital image processing for wide-angle highly spatially variant imagers (2014)

High resolution, wide field-of-view and large depth-of-focus imaging systems are greatly desired and have received much attention from researchers who seek to extend the capabilities of cameras. Monocentric lenses are superior in performance over other wide field-of-view lenses with the drawback that they form a hemispheric image plane which is incompatible with current sensor technology. Fiber optic bundles can be used to relay the image the lens produces to the sensor's planar surface. This requires image processing to correct for artifacts inherent to fiber bundle image transfer. Using a prototype fiber coupled monocentric lens imager we capture single exposure focal swept images from which we seek to produce extended depth-of-focus images. Point spread functions (PSF) were measured in lab and found to be both angle and depth dependent. This spatial variance enforces the requirement that the inverse problem be treated as such. This synthesis of information allowed us to establish a framework upon which to mitigate fiber bundle artifacts and extend the depth-of-focus of the imaging system.
Coherent state topological cluster state production (2011)

We present results illustrating the construction of 3D topological cluster states with coherent state logic. Such a construction would be ideally suited to wave-guide implementations of quantum optical processing. We investigate the use of a ballistic CSign gate, showing that given large enough initial cat states, it is possible to build large 3D cluster states. We model X and Z basis measurements by displaced photon number detections and x-quadrature homodyne detections, respectively. We investigate whether teleportation can aid cluster state construction and whether the introduction of located loss errors fits within the topological cluster state framework.
High Seebeck Coefficient and Power Factor in n‐Type Organic Thermoelectrics (2017)

Abstract The n‐type thermoelectric properties of [6,6]‐phenyl‐C 61 ‐butyric acid methyl ester (PCBM) are investigated for different solution‐based doping methods. A novel inverse‐sequential doping method where the semiconductor (PCBM) is deposited on a previously cast dopant 4‐(1,3‐dimethyl‐2,3‐dihydro‐1H‐benzoimidazol‐2‐yl)‐ N , N ‐diphenylaniline film to achieve a very high power factor PF ≈ 35 µW m −1 K −2 with a conductivity σ ≈ 40 S m −1 is introduced. It is also shown that n‐type organic semiconductors obey the −1/4 power law relation between Seebeck coefficient S and σ that are previously found for p‐type materials. An analytical model on basis of variable range hopping unifies these results. The power law for n‐type materials is shifted toward higher conductivities by two orders of magnitude with respect to that of p‐type, suggesting strongly that n‐type organic semiconductors can eventually become superior to their p‐type counterparts. Adding a small fraction lower lowest unoccupied molecular orbital material (core‐cyanated naphthalene diimide) into PCBM leads to a higher S for inverse‐sequential doping but not for bulk doping due to different morphologies.
Cache optimization for embedded processor cores (2004)

Embedded microprocessor cores are increasingly being used in embedded and mobile devices. The software running on these embedded microprocessor cores is often a priori known; thus, there is an opportunity for customizing the cache subsystem for improved performance. In this work, we propose an efficient algorithm to directly compute cache parameters satisfying desired performance criteria. Our approach avoids simulation and exhaustive exploration, and, instead, relies on an exact algorithmic approach. We demonstrate the feasibility of our algorithm by applying it to a large number of embedded system benchmarks.
Intratumoral Therapy with IL13-PE38 Results in Effective CTL-Mediated Suppression of IL-13Rα2-Expressing Contralateral Tumors (2006)

When animals with IL-13Ralpha2-expressing D5 tumor (right) were injected with IL13-PE38, right flank tumors expressing the IL-13Ralpha2 chain not only showed dramatic regression but contralateral tumors (left flank) also showed tumor regression. Cell depletion experiments in tumor-bearing animals indicated that both CD8(+) and CD4(+) T cells contribute to the regression of contralateral tumors through CTL activation in the periphery and cellular infiltration into tumors. In addition, intratumoral treatment into s.c. tumors of mice bearing metastatic lung tumors with IL13-PE38 showed not only the reduction of treated s.c. tumor but also the reduction of lung metastasis. Thus, IL13-PE38 mediates an antitumor effect not only directly but also indirectly by inducing a host CD8(+) T cell immune response. Accordingly, targeted cytotoxins may be used to treat local disease even if they cannot be administered systemically, and yet may still induce a reasonable systemic antitumor response.
Prolactin and Growth Hormone Release by Morphine in the Rat: Different Receptor Mechanisms (1982)

Concentrations of prolactin and growth hormone in the serum of rats were significantly increased by morphine. Dose response studies demonstrated that maximum prolactin release required lower doses of morphine than those needed for the maximum growth hormone response. Selective blockade of mu 1 (high affinity) opiate receptor with the irreversible antagonist naloxazone reduced morphine-induced peak concentrations of prolactin by 80 percent while increasing peak growth hormone levels by 250 percent. These results suggest different receptor mechanisms for the opiate modulation of the two hormones. The mu 1 (high affinity) receptor sites appear to mediate the morphine-induced release of prolactin but not growth hormone.
Singlet Oxygen in Lithium−Oxygen Batteries (2020)

Abstract Singlet oxygen ( 1 O 2 ) is one of the most critical species leading to parasitic side reactions and poor reversibility in non‐aqueous Li−O 2 batteries. 1 O 2 is generated via the disproportionation of the superoxide radical (O 2 .− ) in O 2 /Li 2 O 2 electrochemistry. The mechanistic and computational studies on 1 O 2 formation revealed the significant roles of the associated cations, solvation ability of aprotic solvents, H + source, and catalyst/electrode materials. Along with efforts to alleviate 1 O 2 production, trapping and eliminating 1 O 2 have been attempted using molecular agents. Anthracene derivatives trap 1 O 2 and form endoperoxides, which can be quantitatively detected using in situ fluorescence analysis. Physical quenchers that convert 1 O 2 to 3 O 2 are desirable for cycling of Li−O 2 cells because quencher molecules are reusable. We highlight the recent reports on the formation and elimination of 1 O 2 , and challenges and perspectives of suppressing the 1 O 2 effect on the performance of Li−O 2 cells.
Nonnegative Matrix Factorization applied to reordered pixels of single images based on patches to achieve structured nonnegative dictionaries (2015)

Recent improvements in computing allow for the processing and analysis of very large datasets in a variety of fields. Often the analysis requires the creation of low-rank approximations to the datasets leading to efficient storage. This article presents and analyzes a novel approach for creating nonnegative, structured dictionaries using NMF applied to reordered pixels of single, natural images. We reorder the pixels based on patches and present our approach in general. We investigate our approach when using the Singular Value Decomposition (SVD) and Nonnegative Matrix Factorizations (NMF) as low-rank approximations. Peak Signal-to-Noise Ratio (PSNR) and Mean Structural Similarity Index (MSSIM) are used to evaluate the algorithm. We report that while the SVD provides the best reconstructions, its dictionary of vectors lose both the sign structure of the original image and details of localized image content. In contrast, the dictionaries produced using NMF preserves the sign structure of the original image matrix and offer a nonnegative, parts-based dictionary.
Cosuppression of a Plasma Membrane H+-ATPase Isoform Impairs Sucrose Translocation, Stomatal Opening, Plant Growth, and Male Fertility (2000)

The plasma membrane H(+)-ATPase builds up a pH and potential gradient across the plasma membrane, thus activating a series of secondary ion and metabolite transporters. pma4 (for plasma membrane H(+)-ATPase 4), the most widely expressed H(+)-ATPase isogene in Nicotiana plumbaginifolia, was overexpressed in tobacco. Plants that overexpressed PMA4 showed no major changes in plant growth under normal conditions. However, two transformants were identified by their stunted growth, slow leaf initiation, delayed stem bolting and flowering, and male sterility. Protein gel blot analysis showed that expression of the endogenous and transgenic pma4 was cosuppressed. Cosuppression was developmentally regulated because PMA4 was still present in developing leaves but was not detected in mature leaves. The glucose and fructose content increased threefold, whereas the sucrose content remained unchanged. The rate of sucrose exudation from mature leaves was reduced threefold and the sugar content of apical buds was reduced twofold, suggesting failure of sucrose loading and translocation to the sink tissues. Cosuppression of PMA4 also affected the guard cells, stomatal opening, and photosynthesis in mature leaves. These results show that a single H(+)-ATPase isoform plays a major role in several transport-dependent physiological processes.
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression (2021)

Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 <i>in vitro</i> and <i>in vivo</i>, representing a viable therapeutic strategy for cancer treatment. Using phage display techniques, we previously identified a potent peptide activator of P53, termed PMI (TSFAEYWNLLSP), with binding affinities for both MDM2 and MDMX in the low nanomolar concentration range. Here we report an ultrahigh affinity, dual-specificity peptide antagonist of MDM2 and MDMX obtained through systematic mutational analysis and additivity-based molecular design. Functional assays of over 100 peptide analogs of PMI using surface plasmon resonance and fluorescence polarization techniques yielded a dodecameric peptide termed PMI-M3 (LTFLEYWAQLMQ) that bound to MDM2 and MDMX with <i>K</i> <sub>d</sub> values in the low picomolar concentration range as verified by isothermal titration calorimetry. Co-crystal structures of MDM2 and of MDMX in complex with PMI-M3 were solved at 1.65 and 3.0 Å resolution, respectively. Similar to PMI, PMI-M3 occupied the P53-binding pocket of MDM2/MDMX, which was dominated energetically by intermolecular interactions involving Phe3, Tyr6, Trp7, and Leu10. Notable differences in binding between PMI-M3 and PMI were observed at other positions such as Leu4 and Met11 with MDM2, and Leu1 and Met11 with MDMX, collectively contributing to a significantly enhanced binding affinity of PMI-M3 for both proteins. By adding lysine residues to both ends of PMI and PMI-M3 to improve their cellular uptake, we obtained modified peptides termed PMI-2K (KTSFAEYWNLLSPK) and M3-2K (KLTFLEYWAQLMQK). Compared with PMI-2K, M3-2K exhibited significantly improved antitumor activities <i>in vitro</i> and <i>in vivo</i> in a P53-dependent manner. This super-strong peptide inhibitor of the P53-MDM2/MDMX interactions may become, in its own right, a powerful lead compound for anticancer drug development, and can aid molecular design of other classes of P53 activators as well for anticancer therapy.
Development of an Engineering Education Program for Innovation in Global Environment (2016)

We developed an engineering educational program for fostering innovative and global engineers. The program is based on multidisciplinary, global, and industry-academia collaborating Project Based Learning (PBL) courses, and has been implemented as part of the Systems Engineering Education at Shibaura Institute of Technology. We define the educational goal of these courses by emphasizing the systems approach with interdisciplinary and cross cultural communication and teamwork skills for solving real issues in the globalizing society. Three PBL courses in the program focus on outcomes which can be achieved by educational environment with diverse students from different engineering and science disciples. The quality assurance of the education program has been achieved by assessing its learning outcomes based on the results of rubrics and a test called Progress Report on Generic Skills in the program.
Characteristic Analysis of Directly Coupled HTS dc-SQUID Magnetometer With Superconducting Film Magnetic-Shield Considering Josephson-Junction Resistance (2012)

A high temperature superconducting quantum interface device (HTS SQUID) is an extremely sensitive magnetic sensor. The HTS SQUID is required to have a high robustness with respect to magnetic noise for stable operation outside a magnetic shielding room. In order to achieve the high robustness of HTS SQUID, use of a magnetic shield with a superconducting film has been proposed, and its effectiveness has been confirmed in the experiments. In this paper, an electromagnetic field simulation was performed using the 3-D edge finite element method to confirm the effectiveness of the superconducting film magnetic-shield. Since both the SQUID magnetometer and the superconducting film magnetic-shield are made of HTS, it is required to consider the HTS characteristics in the electromagnetic field simulation. Additionally, the SQUID magnetometer has Josephson junction. In this paper, the property of the Josephson junction is also considered. The simulation accuracy depending on the type of the finite element mesh is also investigated.
Research and practice of innovative education model in medical school (2009)

The three fundamental elements of the innovative education are sense of creation, crea-tive thinking and creativity. Bethune Medical School of Jilin University focuses on the research of innovativeeducation model through the following means : to develop the creation sense by re-optimization of the teach-ing institutes, setting the scientific and systematic curriculum as well as adopting variable teaching methodsand teaching evaluation system; to cultivate the creative thinking by infiltrating scientific thinking methodsinto the clinical education ; to enhance the students ' creativity by increasing their experiment opportunities.

Key words: 
Creation;  Educational model;  Medical student
A Novel Family of Developmentally Regulated Mammalian Transcription Factors Containing the TEA/ATTS DNA Binding Domain (1996)

We describe the molecular cloning of two novel human and murine transcription factors containing the TEA/ATTS DNA binding domain and related to transcriptional enhancer factor-1 (TEF-1). These factors bind to the consensus TEA/ATTS cognate binding site exemplified by the GT-IIC and Sph enhansons of the SV40 enhancer but differ in their ability to bind cooperatively to tandemly repeated sites. The human TEFs are differentially expressed in cultured cell lines and the mouse (m)TEFs are differentially expressed in embryonic and extra-embryonic tissues in early post-implantation embryos. Strikingly, at later stages of embryogenesis, mTEF-3 is specifically expressed in skeletal muscle precursors, whereas mTEF-1 is expressed not only in developing skeletal muscle but also in the myocardium. Together with previous data, these results point to important, partially redundant, roles for these TEF proteins in myogenesis and cardiogenesis. In addition, mTEF-1 is strongly coexpressed with mTEF-4 in mitotic neuroblasts, while accentuated mTEF-4 expression is also observed in the gut and the nephrogenic region of the kidney. These observations suggest additional roles for the TEF proteins in central nervous system development and organogenesis.
Human diamine oxidase is readily released from activated neutrophils ex vivo and in vivo but is rarely elevated in bacteremic patients (2020)

During human diamine oxidase (DAO) ELISA development we noticed that in serum DAO concentrations appear to be higher when compared to plasma. Neutrophils contain DAO in the specific granules and we hypothesized that DAO is released from neutrophils during serum coagulation. If activation of neutrophils can release DAO, its concentrations might be elevated in vivo after lipopolysaccharide (LPS) administration and in bacteremic patients. Using blood from healthy volunteers DAO concentrations were measured ex vivo in serum, citrate, EDTA and heparin plasma over several hours and after activation of neutrophils. Lipopolysaccharide and granulocyte-colony stimulating factor (G-CSF) were administered to 15 and 8 healthy volunteers, respectively and DAO concentrations were measured at different timepoints. DAO antigen levels were also determined in three different subcohorts of patients with culture-proven bacteremia and high C-reactive protein (CRP) levels. DAO concentrations were elevated in a time-dependent manner in serum but not in EDTA or citrate plasma (<i>P</i> < 0.01). Neutrophil activation using phorbol myristate acetate (PMA) and zymosan dose-dependently caused DAO concentrations to be elevated more than 10-fold at both 22°C and 37°C (both <i>P</i>-values <0.001). Administration of LPS to healthy volunteers released DAO from neutrophils (<i>P</i> < 0.001). Of the 55 different bacteremic patients selected from three independent cohorts only 3 (5.4%) showed highly elevated DAO concentrations. Serum DAO concentrations do not accurately reflect circulating enzyme levels but coagulation-induced neutrophil activation and consequently DAO release. Only a few bacteremic patients show high DAO concentrations able to degrade histamine rapidly.
Familial relative risks for breast cancer by pathological subtype: a population-based cohort study (2010)

FRR for breast cancer was significantly increased for both ER-negative and ER-positive disease. Including receptor status in conjunction with genetic status may aid risk prediction in women with a family history.
Long‐term potentiation of synaptic acetylcholine release in the superior cervical ganglion of the rat. (1985)

The release of endogenous acetylcholine (ACh) from the in vitro rat superior cervical ganglion was measured by assaying the bathing medium. Simultaneously, synaptic transmission in the ganglion was assessed by recording post-ganglionic compound action potentials. A brief period of tetanic preganglionic stimulation (20 Hz for 20 s) induced a long-term potentiation of the post-ganglionic compound action potential. The same tetanic stimulation also consistently induced a long-term potentiation of stimulated ACh release. Spontaneous (non-stimulated) ACh release was not enhanced after tetanic stimulation. The content of ACh in the ganglion was not measurably increased after tetanic stimulation. These results suggest that the long-term increase in synaptic efficacy is due, at least in part, to an increase in the amount of ACh released by the afferent impulse.