gebhart/patrepeval huggingface dataset:
Collaborative adaptive filtering in the complex domain (2008)

A novel hybrid filter combining the complex least mean square (CLMS) and augmented CLMS (ACLMS) algorithms for complex domain adaptive filtering is introduced. The ACLMS has been shown to have improved performance in terms of prediction of non-circular complex data compared to that of the CLMS. By taking advantage of this along with the faster convergence of the CLMS, the hybrid filter is shown to give improved performance over both algorithms for both circular and non-circular data. Simulations on complex-valued synthetic and real world data support the effectiveness of this approach.
Protection of ground water by immobilization of heavy metals in industrial-waste-impacted soil systems (1986)

Immobilization processes in soil/waste systems impacted by hazardous wastes containing heavy metals were investigated. Samples of contaminated material (soil and/or waste) from nine sites in the Intermountain West and California included milling, electroplating, cement kiln dust, petroleum, and tailing and waste rock from mining operations. A sequential extraction procedure, originally developed to fractionate metals in sludge-amended soils into water soluble, mobile, and plant-available forms, was used to obtain preliminary identification of the leachable-metal fraction for the hazardous-waste-contaminated soils studied. Sorption kinetics and batch sorption/desorption studies were performed to determine the interaction of Cu and Cd, from an acidic leachate of a mine waste, with calcareous soils. Solid phase diagrams, exchange models, and GEOCHEM were used to define the mechanisms of metal attenuation of these soils.
Selective Chemical Upcycling of Mixed Plastics Guided by a Thermally Stable Organocatalyst (2020)

Abstract Chemical recycling of plastic waste represents a greener alternative to landfill and incineration, and potentially offers a solution to the environmental consequences of increased plastic waste. Most plastics that are widely used today are designed for durability, hence currently available depolymerisation methods typically require harsh conditions and when applied to blended and mixed plastic feeds generate a mixture of products. Herein, we demonstrate that the energetic differences for the glycolysis of BPA‐PC and PET in the presence of a protic ionic salt TBD:MSA catalyst enables the selective and sequential depolymerisation of these two commonly employed polymers. Employing the same procedure, functionalised cyclic carbonates can be obtained from both mixed plastic wastes and industrial polymer blend. This methodology demonstrates that the concept of catalytic depolymerisation offers great potential for selective polymer recycling and also presents plastic waste as a “greener” alternative feedstock for the synthesis of high added value molecules.
The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells (2019)

We and others have previously shown that the canonical nuclear factor kappa-B (NF-κB) pathway is essential to nasopharyngeal carcinoma (NPC) tumor development and angiogenesis, suggesting that the NF-κB pathway, including its upstream modulators and downstream effectors, are potential therapeutic targets for NPC. The inhibitor of upstream IκB kinase (IKK), PS1145, is a small molecule which can specifically inhibit the IκB phosphorylation and degradation and the subsequent nuclear translocation of NF-κB. The present study aims to determine the anti-tumor activity of PS1145 on NPC. Our results showed that PS1145 significantly inhibited the growth of tumorigenic NPC cell lines, but not in the normal nasopharyngeal epithelial cell line. Results in the in vivo study showed that low concentration of PS1145 (3 mg/kg) could significantly suppress the subcutaneous tumor formation in the nude mice bearing NPC xenografts. Apparent adverse effects were not observed in the animal study. Drug resistance against PS1145 seems to be associated with the increased levels of active NF-kB p65 and change of expression levels of kruppel-like factor 4. As can be seen, PS1145 appears to be a safe agent for animal experiments and its effects are tumor-specific, and the proteins associated with the drug resistance of PS1145 are implied.
An assessment of the susceptibility of bacterial cellulose films to fouling by mold fungi (2020)

An assessment of susceptibility of bacterial cellulose films to fouling by mold fungi. The article presents the results of research on the degree of fouling of films made of bacterial cellulose by selected mold fungi. The degree of fouling of the cellulose film was compared with the degree of fouling of pine wood samples. On the basis of the obtained results, it was found that the cellulose film is covered by mold fungi. At the same time, it was found that T. viride grows on wood much faster than bacterial cellulose.
Shaping the sperm head: an ER enzyme leaves its mark (2006)

Lipid storage diseases are debilitating inherited metabolic disorders that stem from the absence of specific lysosomal enzymes that degrade selected lipids. Most characteristically, these disorders affect the nervous and the reticulo-endothelial systems, with massive organomegaly resulting from the presence of engorged, lipid-laden macrophages. In this issue of the JCI, Yildiz et al. describe the role of the ER-resident enzyme beta-glucosidase 2 (GBA2) in mice (see the related article beginning on page 2985). Surprisingly, GBA2 deficiency leaves bile acid and cholesterol metabolism intact, instead causing lipid accumulation in the ER of testicular Sertoli cells, round-headed sperm (globozoospermia), and impaired male fertility.
Target detection and tracking analysis of moving object based on PCLFM simulated model for airborne satellite communication (2016)

Pulse Compression Linear Frequency Modulation (PCLFM) waveform is widely used in wideband radars such as Synthetic Aperture Radar (SAR) and Inverse Synthetic Aperture Radar (ISAR). But the LFM waveform suffers from range migration, if the target to be detected and it has a high velocity that the pulses cannot be coherently integrated. A novel method based on wideband matched filter is proposed to eliminate the effect of speed. Both theory analysis and simulations shows that the new method can integrate the energy of the echo reflected from the target effectively.
Supplementary Figure 4 from Expression of P2X7 Receptor Increases <i>In Vivo</i> Tumor Growth (2023)

&lt;p&gt;PDF file, 72KB, Fig. S4. Effect of P2X7 silencing on ACN neuroblastoma growth. Panel A, P2X7 expression in ACN neuroblastoma cells transfected with P2X7-specific or scrambled shRNA. Cell protein was extracted, run on SDS PAGE, blotted and stained with an anti-P2X7-selective polyclonal Ab. Panel B, densitometric analysis of P2X7 bands. Panel C, volumes of tumors excised at d 18 post-inoculum.&lt;/p&gt;
Ethanol at Levels Produced by Saccharomyces cerevisiae during Wheat Dough Fermentation Has a Strong Impact on Dough Properties (2014)

Yeast's role in bread making is primarily the fermentative production of carbon dioxide to leaven the dough. Fermentation also impacts dough matrix rheology, thereby affecting the quality of the end product. Surprisingly, the role of ethanol, the other yeast primary metabolite, has been ill studied in this context. Therefore, this study aims to assess the potential impact of ethanol on yeastless dough extensibility and spread and gluten agglomeration at concentrations at which it is produced in fermenting dough, i.e., up to 60 mmol per 100 g of flour. Reduced dough extensibility and dough spread were observed upon incorporation of ethanol in the dough formula, and were more pronounced for a weak than for a strong flour. Uniaxial and biaxial extension tests showed up to 50% decrease in dough extensibility and a dough strength increase of up to 18% for 60 mmol of ethanol/100 g of flour. Ethanol enhanced gluten agglomeration of a weak flour. Sequential extraction of flour in increasing ethanol concentrations showed that better gluten-solvent interaction is a possible explanation for the changed dough behavior.
Photo‐Cleavable Cryptands: Synthesis and Structure (1991)

Abstract The four photo‐cleavable ligands 1 – 4 of the macrobicyclic‐cryptand type have been synthesized by introducing a photo‐sensitive 2‐nitrobenzyl‐ or 4,5‐dimethoxy‐2‐nitrobenzyl‐ether bond into one of the bridges. These compounds are expected to retain the selective binding features of the parent cryptands and to allow the photolytically induced release of alkali ions in aqueous solution. The crystal structures of the ligand 5‐(2‐nitro‐phenyl)‐4,7,13,16,21,24‐hexaoxa‐1,10‐diazabicyclo[8.8.8]hexacosane ( 3 ) and of its KSCN complex 13 have been determined. They are analogous to those of the corresponding parent species, confirming the macrobicyclic geometry and the cryptate nature of the complex. Spectroscopic properties are reported.
Guided Weapon Control Systems (1979)

Guided weapon control systems , Guided weapon control systems , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Cambodunum. Ausgrabungen Herbst 1925 (2015)

[nicht vorhanden / not available]
Taming Electrowetting Using Highly Concentrated Aqueous Solutions (2022)

Wetting of carbon surfaces is one of the most widespread, yet poorly understood, physical phenomena. Control over wetting properties underpins the operation of aqueous energy-storage devices and carbon-based filtration systems. Electrowetting, the variation in the contact angle with an applied potential, is the most straightforward way of introducing control over wetting. Here, we study electrowetting directly on graphitic surfaces with the use of aqueous electrolytes to show that reversible control of wetting can be achieved and quantitatively understood using models of the interfacial capacitance. We manifest that the use of highly concentrated aqueous electrolytes induces a fully symmetric and reversible wetting behavior without degradation of the substrate within the unprecedented potential window of 2.8 V. We demonstrate where the classical "Young-Lippmann" models apply, and break down, and discuss reasons for the latter, establishing relations among the applied bias, the electrolyte concentration, and the resultant contact angle. The approach is extended to electrowetting at the liquid|liquid interface, where a concentrated aqueous electrolyte drives reversibly the electrowetting response of an insulating organic phase with a significantly decreased potential threshold. In summary, this study highlights the beneficial effect of highly concentrated aqueous electrolytes on the electrowettability of carbon surfaces, being directly related to the performance of carbon-based aqueous energy-storage systems and electronic and microfluidic devices.
Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles (2015)

The SNAr reaction of 2,4-dichloropyrimidines, further substituted with an electron-withdrawing substituent at C-5, has selectivity for substitution at C-4. Here we report that tertiary amine nucleophiles show excellent C-2 selectivity. In situ N-dealkylation of an intermediate gives the product that formally corresponds to the reaction of a secondary amine nucleophile at C-2. This reaction is practical (fast under simple reaction conditions, with good generality for tertiary amine structure and moderate to excellent yields) and significantly expands access to pyrimidine structures.
An unsupervised method for clustering images based on their salient regions of interest (2006)

We have developed a biologically-motivated, unsupervised way of grouping together images whose salient regions of interest (ROIs) are perceptually similar regardless of the visual contents of other (less relevant) parts of the image. In the implemented model cluster membership is assigned based on feature vectors extracted from salient ROIs. This paper focuses on the experimental evaluation of the proposed approach for several combinations of feature extraction techniques and unsupervised clustering algorithms. The results reported here show that this is a valid approach and encourage further research.
RNAi Vectors for Manipulation of Gene Expression in Higher Plants (2008)

RNA interference (RNAi) is a homology-dependent gene silencing technology in which small interfering RNAs (siRNAs) direct RNA cleavage or DNA methylation. After transcription of an RNAi cassette including inverted repeat sequences against the target gene and a spacer fragment, the resultant transcript forms a hairpin-like structure. The stem region of hairpin RNAs is processed into siRNAs. Here we focus on the structural properties of RNAi vectors that affect the silencing efficiency, and caveats in the evaluation of RNAi phenotype are discussed. Subsequently, several RNAi applications including simultaneous silencing of multiple gene sequences and specific silencing of a member in the gene family were discussed. In addition a newly developed RNAi technology, artificial microRNA, is also introduced.
Ankle biomechanics of ballet Dancers in relevé en pointé dance (2005)

The objective of this study was to study the ankle biomechanics in relevé en pointé of ballet dancers and to investigate the symmetry between dominant and nondominant sides. A three-dimensional motion analysis system and two force platforms were used to collect segmental motion and ground reaction force data during relevé en pointé dancing. Thirteen ballet dancers, each of whom had over 5 years' dance experience (11.37 +/- 3.9 years), were recruited for this study. The results showed that ankle movement patterns were highly correlated (ICC = 0.99) in bilateral comparisons, but only moderate correlation was found in ankle joint moment patterns (ICC = 0.66). The nonldominant ankle showed the same excursion patterns, but different joint moments, when compared to the dominant ankle in relevé en pointé. The indication was that the two ankle joints may play different roles in controlling balance and movements throughout the entire period of the dance movements. Ankle bionmechanical patterns of the fiundamental ballet dance movement, relevé en pointé, also were constructed in this study to help interpret and understand the bilateral ankle joint excursion pattern.
K-means and adaptive k-means algorithms for clustering DNS traffic (2011)

Internet Service Providers' DNS traffic can be up to 120000 queries per second and increases around 8% every month. DNSSEC is expected to replace DNS and brings new challenge to naming resolution with heavy signature check. This paper provides an architecture, where incoming DNS traffic is split according to the DNS query rather than to its IP address, in order to minimize the number of signature checks. To split DNS traffic among the different nodes of the platform, k-means clustering algorithms are considered. This paper proposes an enhancement of the standard algorithm: an adaptive k-means and compares performance of both methods on simulated data from a Gaussian mixture model and on real DNS traffic data from the Orange IP network.
Don't let SAD get you down this season (2008)

In Brief Seasonal affective disorder is characterized by an onset of recurrent major depressive episodes during the fall or winter, followed by a full remission or hypomanic/manic episode in the spring or summer. It is essential to determine the time of onset and remission of depressive episodes, including a confirmation that symptoms follow a seasonal pattern for at least 2 years.
Adaptive Methods for Linear Programming Decoding (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Detectability of failures of linear programming (LP) decoding and the potential for improvement by adding new constraints motivate the use of an adaptive approach in selecting the constraints for the underlying LP problem. In this paper, we make a first step in studying this method, and show that by starting from a simple LP problem and adaptively adding the necessary constraints, the complexity of LP decoding can be significantly reduced. In particular, we observe that with adaptive LP decoding, the sizes of the LP problems that need to be solved become practically independent of the density of the parity-check matrix. We further show that adaptively adding extra constraints, such as constraints based on redundant parity checks, can provide large gains in the performance. </para>
Reconstruction and Deconstruction in Contemporary Philosophy: Variations on a Kantian Theme (1991)

There is widespread agreement now that the critique of reason can be carried on only in conjunction with historical, social, and cultural analysis. But there is sharp disagreement as to just what form that critique should take. Arrayed along one side of the main front are those who, in the wakes of Nietzsche and Heidegger, attack enlightenment conceptions at their very roots, and along the other side, those who, in the wakes of Hegel and Marx, attempt to recast those conceptions in sociohistorical terms. This paper defends a position analogous to Kant's: ideas of reason are both necessary to thought and persistent sources of illusion. In the first part it examines some of the problems encountered by thinkers who take only the negative tack. Though their emphasis on the particular, changeable, and contingent is an understandable reaction to the traditional preoccupation with the universal, timeless, and necessary, it is, I argue, no less one-sided for that, nor any less questionable in its practical implications. The conclusion I try to reach along this path is that socialpractical analogues to Kant's ideas of reason are so deeply embedded in our form of life as to make doing without them unimaginableand undesirable. In the second part, it examines various aspects of Habermas's attempt to develop a more balanced approach. Kant's ideas of reason reappear there as pragmatic presuppositions of communication, more specifically as idealizing suppositions we cannot avoid making while attempting to arrive at mutual understanding. In reconstructing these idealizing presuppositions of communicative reason, however, Habermas does not give sufficient weight to the sorts of ontological presuppositions that occupy deconstructionists under the rubrics of language, culture, Seinsgeschick, diffirance, power, and the like. This, I argue, is what lends his project the transcendental air that so exercises his critics. The last part of the paper argues broadly that deconstructive concerns can be integrated into the reconstructive project, and can serve there as antidotes to the deepseated tendency to hypostatize ideas of reason into completely realized or realizeable states of affairs. The key to this approach is a shift in the level of the critique of impure reason from the negative
Non-rigid matching using demons (1996)

We present the concept of non-rigid matching based on demons, by reference to Maxwell's demons. We contrast this concept with the more conventional viewpoint of attraction. We show that demons and attractive points are clearly distinct for large deformations, but also that they become similar for small displacements, encompassing techniques close to optical flow. We describe a general iterative matching method based on demons, and derive from it three different non-rigid matching algorithms, one using all the image intensities, one using only contours, and one for already segmented images. At last, we present results with synthesized and real deformations, with applications to Computer Vision and Medical Image Processing.
Abstract 3925: Production and biochemical characterization of farnesylated and methylated KRAS4b using engineered baculovirus (2015)

Abstract KRAS4b, which is frequently mutated in pancreatic, colon and lung cancers, is processed in several steps including farnesylation by farnesyl-transferase (FNT); proteolytic cleavage at the C-terminus by ras converting enzyme 1 (RCE1) and carboxymethylation by isoprenylcysteine carboxymethyl transferase (ICMT). Plasma membrane localization of KRAS4b requires this processing as does KRAS4b-dependent RAF kinase activation. Previous attempts to produce modified KRAS have relied on protein engineering approaches or in vitro farnesylation of bacterially expressed KRAS protein. The proteins produced by these methods do not completely replicate the final KRAS protein found in mammalian cells and the yield and quality of the protein are typically low. Using an engineered baculovirus containing the two subunits of farnesyl-transferase (FNTA/B) and a maltose-binding protein (MBP)-KRAS4b fusion we are able to produce highly purified, farnesylated, and methylated KRAS4b (FMe-KRAS4b) in insect cells at yields of approximately 10mg/L. This protein has been extensively characterized by electrospray-ionization mass spectrometry, analytical ultracentrifugation, and circular dichroism. In addition, we demonstrate that FMe-KRAS4b is fully active in hydrolyzing GTP, binding to RAF-RBD, and interacting with lipid nanodiscs. Citation Format: Andrew G. Stephen, William K. Gillette, Carissa Grose, Dominic Esposito. Production and biochemical characterization of farnesylated and methylated KRAS4b using engineered baculovirus. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3925. doi:10.1158/1538-7445.AM2015-3925
Feasibility of Large-Scale Phosphoproteomics with Higher Energy Collisional Dissociation Fragmentation (2010)

Mass spectrometry (MS)-based proteomics now enables the analysis of thousands of phosphorylation sites in single projects. Among a wide range of analytical approaches, the combination of high resolution MS scans in an Orbitrap analyzer with low resolution MS/MS scans in a linear ion trap has proven to be particularly successful ("high-low" strategy). Here we investigate if the improved sensitivity of higher energy collisional dissociation (HCD) on an LTQ-Orbitrap Velos instrument allows a "high-high" strategy. A high resolution MS scan was followed by up to 10 HCD MS/MS scans, and we achieved cycle times of about 3 s making the method compatible with chromatographic time scales. Fragment mass accuracy increased about 50-fold compared to the "high-low" strategy. Unexpectedly, the HCD approach mapped up to 16,000 total phosphorylation sites in one day's measuring time--the same or better than the standard high-low strategy. Reducing the target values from a standard of 30,000 to 5000 ions did not severely affect identification rates but did decrease identification and localization scores for phosphorylation sites. We conclude that HCD in the new configuration is now a viable method for large-scale phosphoproteome analysis alongside collisional induced dissociation, (CID) and electron capture/transfer dissociation (ECD/ETD).