gebhart/patrepeval huggingface dataset:
Loop-mediated isothermal amplification-lateral-flow dipstick (LAMP-LFD) to detect Mycoplasma ovipneumoniae (2019)

In order to establish a rapid detection method for Mycoplasma ovipneumoniae, this study used the loop-mediated isothermal amplification (LAMP) technique to carry out nucleic acid amplification and chromatographic visualization via a lateral flow dipstick (LFD) assay. The M. ovipneumoniae elongation factor TU gene (EF-TU) was detected using a set of specific primers designed for the EF-TU gene, and the EF-TU FIP was detected by biotin labeling, which was used in the LAMP amplification reaction. The digoxin-labeled probe specifically hybridized with LAMP products, which were visually detected by LFD. Here, we established the M. ovipneumoniae LAMP-LFD rapid detection method and tested the specificity, sensitivity, and clinical application of this method. Results showed that the optimized LAMP performed at 60 °C for 60 min, and LFD can specifically and visually detect M. ovipneumoniae with a minimum detectable concentration at 1.0 × 102 CFU/mL. The sensitivity of LAMP-LFD was 1000 times that of the conventional PCR detection methods, and the clinical lung tissue detection rate was 86% of 50 suspected sheep infected with M. ovipneumoniae. In conclusion, LAMP-LFD was established in this study to detect M. ovipneumoniae, a method that was highly specific, sensitive, and easy to operate, and provides a new method for the prevention and diagnosis of M. ovipneumoniae infection.
Evaluation of Seismic Performance for an Internally Confined Hollow CFT Column (2007)

Column tests were performed for a new type of column, the internally confined hollow concrete filled tube column (ICH CFT column), to evaluate its seismic performance. The seismic performances for two types of ICH CFT columns and a general solid RC column were evaluated and compared by quasi-static tests. The displacements and the lateral loads of column specimens were measured during tests. Ductilities, absorbed energy, equivalent damping ratios, damage indices were calculated from recorded data. From the test results, the ICH CFT column shows superior seismic performances with double moment capacity and larger energy absorbing capacity over that of a solid RC column.
Requirement of α5-GABAAReceptors for the Development of Tolerance to the Sedative Action of Diazepam in Mice (2004)

Despite its pharmacological relevance, the mechanism of the development of tolerance to the action of benzodiazepines is essentially unknown. The acute sedative action of diazepam is mediated via alpha1-GABA(A) receptors. Therefore, we tested whether chronic activation of these receptors by diazepam is sufficient to induce tolerance to its sedative action. Knock-in mice, in which thealpha1-,alpha2-,alpha3-, oralpha(5)-GABA(A) receptors had been rendered insensitive to diazepam by histidine-arginine point mutation, were chronically treated with diazepam (8 d; 15 mg x kg(-1) x d(-1)) and tested for motor activity. Wild-type, alpha2(H101R), and alpha3(H126R) mice showed a robust diminution of the motor-depressant drug action. In contrast, alpha5(H105R) mice failed to display any sedative tolerance. alpha1(H101R) mice showed no alteration of motor activity with chronic diazepam treatment. Autoradiography with [3H]flumazenil revealed no change in benzodiazepine binding sites. However, a decrease in alpha5-subunit radioligand binding was detected selectively in the dentate gyrus with specific ligands. This alteration was observed only in diazepam-tolerant animals, indicating that the manifestation of tolerance to the sedative action of diazepam is associated with a downregulation of alpha5-GABA(A) receptors in the dentate gyrus. Thus, the chronic activation of alpha(5)-GABA(A) receptors is crucial for the normal development of sedative tolerance to diazepam, which manifests itself in conjunction with alpha1-GABA(A) receptors.
Frequency dependent finite‐difference–time‐domain [(fd)2td] formulation applied to ferrite material (1994)

Abstract When subjected to a constant magnetic field, ferrites exhibit anisotropic constitutive parameters. This anisotropy can be described in the frequency domain by using a permeability tensor [μ(ω)] instead of the usual scalar permeability. This article introduces a new method to analyze saturated ferrite structures by a FDTD algorithm where the convolution between the permeability tensor [μ(t)] = F −1 ([μ(ω)]) and the magnetic field H(t) = F −1 (H(ω)) are to be calculated. Results are obtained for a two‐dimensional problem and are compared with those given by direct differential FDTD algorithm [1] and a mode‐matching method [2]. © 1994 John Wiley &amp; Sons, Inc.
Picosecond laser welding of similar and dissimilar materials (2014)

We report picosecond laser welding of similar and dissimilar materials based on plasma formation induced by a tightly focused beam from a 1030 nm, 10 ps, 400 kHz laser system. Specifically, we demonstrate the welding of fused silica, borosilicate, and sapphire to a range of materials including borosilicate, fused silica, silicon, copper, aluminum, and stainless steel. Dissimilar material welding of glass to aluminum and stainless steel has not been previously reported. Analysis of the borosilicate-to-borosilicate weld strength compares well to those obtained using similar welding systems based on femtosecond lasers. There is, however, a strong requirement to prepare surfaces to a high (10-60 nm Ra) flatness to ensure a successful weld.
Characterization and optimization of pulse drivers for switched mode power amplifier measurements (2014)

This paper focuses on the evaluation of pulse drivers for the use in class-S power amplifier setups with respect to linearity. Nonlinear effects are likely to degrade the overall system performance, though they are hard to characterize especially in an early stage of design. Based on measurements conducted with a configurable pulse driver, namely Triquint's TGA4954-SL, a simple gauging method was developed. It allows the identification of favorable bias-parameter settings or the comparison of different devices while requiring only very little knowledge of the overall system.
Inhibition of p73 function by Pifithrin-α as revealed by studies in zebrafish embryos (2008)

The p53 family of proteins contains two members that have been implicated in sensitization of cells and organisms to genotoxic stress, i.e., p53 itself and p73. In vitro, lack of either p53 or p73 can protect certain cell types in the adult organism against death upon exposure to DNA damaging agents. The present study was designed to assess the relative contribution of p53 to radiation resistance of an emerging vertebrate model organism, i.e., zebrafish embryos. Consistent with previous reports, suppressing p53 protein expression using antisense morpholino oligonucleotides (MOs) increased survival and reduced gross morphological alterations in zebrafish embryos exposed to ionizing radiation. By contrast, a pharmacological inhibitor of p53 function [Pifithrin-alpha(PFTalpha)] caused developmental abnormalities affecting the head, brain, eyes and kidney function and did not protect against lethal effects of ionizing radiation when administered at 3 hours post fertilization (hpf). The phenotypic abnormalities associated with PFTalpha treatment were similar to those caused by antisense MO knock down (kd) used to reduce p73 expression. PFTalpha also inhibited p73-dependent transcription of a reporter gene construct containing canonical p53-responsive promoter sequences. Notably, when administered at later stages of development (23 hpf), PFTalpha did not cause overt developmental defects but exerted radioprotective effects in zebrafish embryos. In summary, this study highlights off-target effects of the pharmacological p53 inhibitor PFTalpha related to inhibition of p73 function and essential roles of p73 at early but not later stages of zebrafish development.
Phase Transitions in Image Denoising via Sparsely Coding Convolutional Neural Networks (2017)

Neural networks are analogous in many ways to spin glasses, systems which are known for their rich set of dynamics and equally complex phase diagrams. We apply well-known techniques in the study of spin glasses to a convolutional sparsely encoding neural network and observe power law finite-size scaling behavior in the sparsity and reconstruction error as the network denoises 32$\times$32 RGB CIFAR-10 images. This finite-size scaling indicates the presence of a continuous phase transition at a critical value of this sparsity. By using the power law scaling relations inherent to finite-size scaling, we can determine the optimal value of sparsity for any network size by tuning the system to the critical point and operate the system at the minimum denoising error.
Spatially scaled motion-reproduction control using modified motion data (2014)

Modifying data of audio and visual information makes sound from speaker or display size larger or smaller. However, motion data has a different characteristic from audio and visual data in that it is a bilateral information. When the movement of motion data is scaled, it is affected by reaction force from environments. In this paper, the spatially scaled motion data is handled. In the conventional method of motion-copying system, the stored motion is reproduced only when environmental conditions of stored and reproduced phases are same. So, when a motion data is modified, the movement of motion data is changed and reaction force from environments is also changed. Therefore, the change of the different environmental condition affects the control system and the desired modified motion is not reproduced. In this paper, the scaled motion-reproduction control using spatially scaled motion data based on position-based motion-copying system is proposed. The validity of the proposed method is verified by simulations and experiments and the proposed method is effective for size-free motion reproduction and data volume reduction.
Berberine hydrochloride: anticancer activity and nanoparticulate delivery system (2011)

With increasing research on regulation of cancer cell metabolism by berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation.
HOW WOULD YOU LABEL YOUR OWN DRINKING PATTERN OVERALL? AN EVALUATION OF ANSWERS PROVIDED BY 181 HIGH FUNCTIONING MIDDLE-AGED MEN (1999)

The self-rating of drinking habits was compared to DSM-III-R diagnoses of alcohol abuse and dependence in 181 men with an average age (+/- SD) of 38.7 +/- 1.91 years. Results indicate that the 150 subjects without alcohol-related diagnosis (Group 1) rated themselves as 'non-problem drinker', in categories from 'non-drinker' to 'heavy drinker'. Among the 15 individuals with alcohol abuse (Group 2), none rated their drinking pattern as 'problem drinker'. Two (12.5%) subjects in the group of 16 individuals with alcohol dependence (Group 3) rated themselves as 'problem drinker', while most did not consider their drinking patterns as problematic. Within subjects who identified themselves as the same type of drinker (e.g. 'infrequent drinker', 'moderate drinker', etc ...), the quantity, frequency, and number of alcohol-related problems were higher in Groups 2 and 3, compared to Group 1. The self-rating of drinking habits using a single question failed to identify over 90% of the subjects diagnosed with alcohol use disorder (100% of those with alcohol abuse and 87.5% of those with alcohol dependence), and did not differentiate between levels of alcohol intake and number of alcohol-related problems for subjects who identified as a particular drinking type.
Benzo[b]naphtho[2,1‐d]thiophene (thiachrysene) derivatives as potential carcinostatic molecules (1980)

Abstract About twenty compounds of the benzo[ b ]naphtho[2,1‐ d ]thiophene series have been synthesized, namely, 6‐amino derivatives, with the aim of biological testing as possible carcinostatic molecules.
Influence of physician communication on newly diagnosed breast patients' psychologic adjustment and decision-making (1994)

Provision of information needed for decision-making appears to be valued largely within the context of a caring physician-patient relationship. Specific surgeons' behaviors believed to facilitate patient adjustment include expressing empathy, allowing sufficient time for patients to absorb the cancer diagnosis, providing information, and engaging the patient in treatment decision-making.
Calcitonin gene‐related peptide in the joint: contributions to pain and inflammation (2015)

Arthritis is the commonest cause of disabling chronic pain, and both osteoarthritis (OA) and rheumatoid arthritis (RA) remain major burdens on both individuals and society. Peripheral release of calcitonin gene-related peptide (CGRP) contributes to the vasodilation of acute neurogenic inflammation. Contributions of CGRP to the pain and inflammation of chronic arthritis, however, are only recently being elucidated. Animal models of arthritis are revealing the molecular and pathophysiological events that accompany and lead to progression of both arthritis and pain. Peripheral actions of CGRP in the joint might contribute to both inflammation and joint afferent sensitization. CGRP and its specific receptors are expressed in joint afferents and up-regulated following arthritis induction. Peripheral CGRP release results in activation of synovial vascular cells, through which acute vasodilatation is followed by endothelial cell proliferation and angiogenesis, key features of chronic inflammation. Local administration of CGRP to the knee also increases mechanosensitivity of joint afferents, mimicking peripheral sensitization seen in arthritic joints. Increased mechanosensitivity in OA knees and pain behaviour can be reduced by peripherally acting CGRP receptor antagonists. Effects of CGRP pathway blockade on arthritic joint afferents, but not in normal joints, suggest contributions to sensitization rather than normal joint nociception. CGRP therefore might make key contributions to the transition from normal to persistent synovitis, and the progression from nociception to sensitization. Targeting CGRP or its receptors within joint tissues to prevent these undesirable transitions during early arthritis, or suppress them in established disease, might prevent persistent inflammation and relieve arthritis pain.
LCD motion‐blur estimation using different measurement methods (2009)

Abstract— The primary goal of this study was to find a measurement method for motion blur which is easy to carry out and gives results that can be reproduced from one lab to another. This method should be able to also take into account methods for reduction of motion blur such as backlight flashing. Two methods have been compared. The first method uses a high‐speed camera that permits us to directly picture the blurred‐edge profile. The second one exploits the mathematical analysis of the motion‐blur formation to construct the blurred‐edge profile from the temporal step response. Measurement results and method proposals are given and discussed.
Wavelets and electromagnetics (1992)

Wavelets are an exciting new topic in applied mathematics and signal processing. This paper will provide a brief review of wavelets which are also known as families of functions with an emphasis on interpretation rather than rigor. We will derive an indirect use of wavelets for the solution of integral equations based techniques adapted from image processing. Examples for resistive strips will be given illustrating the effect of these techniques as well as their promise in reducing dramatically the requirement in order to solve an integral equation for large bodies. We also will present a direct implementation of wavelets to solve an integral equation. Both methods suggest future research topics and may hold promise for a variety of uses in computational electromagnetics.
Power-Transfer Capacity of a Geared-Neutral Transmission (2007)

Geared-neutral Continuously Variable Transmission (CVT) designs offer various kinematic advantages including a wide ratio range, and elimination of starting devices. However, they suffer from power re-circulation through the Continuously Variable Unit (CVU), which reduces the overall CVT efficiency and increases the CVU contact temperatures. This, in turn, limits the CVT power rating. In this study, the CVU and the CVT design parameters are optimized simultaneously to yield the highest power capacity. The CVU power capacity estimates are based on an instantaneous CVU-contact-temperature of 180°C. It is shown that a CVU design that yields the maximum power capacity is different from a design that yields the highest CVU efficiency.
An infra-red reflectance system for ambulatory characterization of left ventricular function (1982)

An optical method of detecting the arterial pulse is described. The system employs an infra-red light emitting diode (LED) and phototransistor arranged to operate in the reflectance mode and sited over the superficial temporal artery. The LED is pulsed and the signal recovery system performs a synchronous sample-and-hold function on the phototransistor output. This arrangement improves peak light output relative to ambient light and extends battery life. The transducer, used at its site of application over the temporal artery produces an arterial pulse-wave relatively resistant to motion artefact, and is thus suitable for ambulatory monitoring applications. The pulsewave can be used to obtain measurements of left ventricular ejection time with the accuracy required for clinical systolic time interval investigations.
Conversion of B-rep CAD models into globally G1 triangular splines (2020)

Existing techniques that convert B-rep (boundary representation) patches into Clough-Tocher splines guarantee watertight, that is C0, conversion results across B-rep edges. In contrast, our approach ensures global tangent-plane, that is G1, continuity of the converted B-rep CAD models. We achieve this by careful boundary curve and normal vector management, and by converting the input models into Shirman-Séquin macro-elements near their (trimmed) B-rep edges. We propose several different variants and compare them with respect to their locality, visual quality, and difference with the input B-rep CAD model. Although the same global G1 continuity can also be achieved by conversion techniques based on subdivision surfaces, our approach uses triangular splines and thus enjoys full compatibility with CAD.
Dandruff as a Potential Source of DNA in Forensic Casework (1998)

Dandruff is a clinical alteration of the skin that consists histologically of orthokeratotic clumps with minute parakeratotic foci found in inflammatory pathologies such as seborrheic dermatitis and psoriasis. Therefore, some nucleated cells should be found in dandruff and hence there is a possibility that forensically typeable DNA could be extracted from dandruff. Because of a particular case in which we were involved, a study was carried out to determine whether or not DNA could be extracted from dandruff, and if the two most widely used extraction techniques (Chelex and organic) would be applicable. Results show that sufficient quantities of DNA (more than 30 to 40 ng) can be obtained from as little as 1.0 to 1.5 mg of dandruff. Both methods yield DNA, although the organic procedure seems to yield more (72.5 ng Chelex vs. 183.3 ng organic). All the DNA samples extracted were typed correctly for the loci HUMTH01 and HUMvWA. Therefore, dandruff can be considered a potential source of DNA for forensic identification.
Staggered-SAR for high-resolution wide-swath imaging (2012)

Synthetic aperture radar (SAR) is a remote sensing technique, capable of providing high resolution images independent of weather conditions and sunlight illumination. This makes SAR very attractive for the systematic observation of dynamic processes on the Earth’s surface. However, current SAR systems are limited, in that a wide coverage can only be achieved at the expense of a degraded azimuth resolution. To overcome this limitation, an innovative concept is considered, Staggered-SAR, where the pulse repetition frequency (PRF) is continuously varied. High-resolution wide-swath (HRWS) imaging is thus achieved without the need for a long antenna with multiple apertures.
118. Dynamic hepatic scintigraphy predicts survival in colorectal cancer (1993)

Hemingway, D. M.; Warren, H.; Carter, R.; Bessent, R.; McKillop, J.; McArdle, C. S.; Cooke, T. G.Author Information
A rotating light table to measure the lustre of fibres and fabrics (2013)

The Rotating Light Table (RLT) is a light-reflective device developed to measure the surface luster of fibers in various forms - as bundles containing many parallel fibers (e.g., in top form), as small groups of parallel fibers, or even as single fibers. Such fibers may be un-dyed (white/cream), dyed, or naturally colored. The device can compare the relative luster of fiber bundles before and after undergoing surface modification. Comparing the surface luster of cotton sliver before and after mercerization exemplifies the technique. Surface reflectance profiles from &lt; 20 parallel-mounted human hairs orientated root-to-tip, and from single black or light-colored fibers, further exemplify the precision and sensitivity of the technique.
Proximal femoral fractures (2010)

Fractures of the proximal femur include fractures of the head, neck, intertrochanteric, and subtrochanteric regions. Head fractures commonly accompany dislocations. Neck fractures and intertrochanteric fractures occur with greatest frequency in elderly patients with a low bone mineral density and are produced by low-energy mechanisms. Subtrochanteric fractures occur in a predominantly strong cortical osseous region which is exposed to large compressive stresses. Implants used to address these fractures must be able to accommodate significant loads while the fractures consolidate. Complications secondary to these injuries produce significant morbidity and include infection, nonunion, malunion, decubitus ulcers, fat emboli, deep venous thrombosis, pulmonary embolus, pneumonia, myocardial infarction, stroke, and death.
Reactivity Descriptors and Rate Constants for Acid Zeolite Catalyzed Ethylation and Isopropylation of Benzene (2003)

The acid zeolite catalyzed ethylation and isopropylation of benzene with ethene and propene is investigated at the B3LYP/6-31G* level of calculation with a T4-cluster representing the Brønsted acid site of the zeolite. After geometry optimization of reactants, transition structures, and products, a kinetic and a sensitivity analysis were used to model the reactions. These reactions proceed in one step, without formation of alkoxy species or charged intermediates. Both reaction rate constants and local HSAB properties indicate that isopropylation is favored over ethylation, in agreement with experimental observations.
Find your advisor (2010)

We present a robust method for gathering relational facts from the Web, based on matching generalized patterns which are automatically learned from seed facts for relations of interest. Our approach combines these generalized patterns for high recall information extraction with a rule-based, declarative reasoning approach to also ensure high precision. Newly extracted candidate facts are assigned statistical weights which reflect the strengths of the patterns used to extract them. For checking the plausibility of candidate facts with respect to existing knowledge and competing hypotheses, we use an efficient algorithm for weighted Max-Sat over propositional-logic clauses. In contrast to prior work on reasoning-based information extraction, we employ richer statistics and smart pruning to bound the number of grounded rules passed on to the Max-Sat solver.