gebhart/patrepeval huggingface dataset:
A Mutant Isoform of ObgE Causes Cell Death by Interfering with Cell Division (2017)

Cell division is a vital part of the cell cycle that is fundamental to all life. Despite decades of intense investigation, this process is still incompletely understood. Previously, the essential GTPase ObgE, which plays a role in a myriad of basic cellular processes (such as initiation of DNA replication, chromosome segregation, and ribosome assembly), was proposed to act as a cell cycle checkpoint in <i>Escherichia coli</i> by licensing chromosome segregation. We here describe the effect of a mutant isoform of ObgE (ObgE<sup>∗</sup>) that causes cell death by irreversible arrest of the cell cycle at the stage of cell division. Notably, chromosome segregation is allowed to proceed normally in the presence of ObgE<sup>∗</sup>, after which cell division is blocked. Under conditions of rapid growth, ongoing cell cycles are completed before cell cycle arrest by ObgE<sup>∗</sup> becomes effective. However, cell division defects caused by ObgE<sup>∗</sup> then elicit lysis through formation of membrane blebs at aberrant division sites. Based on our results, and because ObgE was previously implicated in cell cycle regulation, we hypothesize that the mutation in ObgE<sup>∗</sup> disrupts the normal role of ObgE in cell division. We discuss how ObgE<sup>∗</sup> could reveal more about the intricate role of wild-type ObgE in division and cell cycle control. Moreover, since Obg is widely conserved and essential for viability, also in eukaryotes, our findings might be applicable to other organisms as well.
Solid-Ionic Memory in a van der Waals Heterostructure (2022)

Defect states dominate the performance of low-dimensional nanoelectronics, which deteriorate the serviceability of devices in most cases. But in recent years, some intriguing functionalities are discovered by defect engineering. In this work, we demonstrate a bifunctional memory device of a MoS<sub>2</sub>/BiFeO<sub>3</sub>/SrTiO<sub>3</sub> van der Waals heterostructure, which can be programmed and erased by solely one kind of external stimuli (light or electrical-gate pulse) via engineering of oxygen-vacancy-based solid-ionic gating. The device shows multibit electrical memory capability (>22 bits) with a large linearly tunable dynamic range of 7.1 × 10<sup>6</sup> (137 dB). Furthermore, the device can be programmed by green- and red-light illuminations and then erased by UV light pulses. Besides, the photoresponse under red-light illumination reaches a high photoresponsivity (6.7 × 10<sup>4</sup> A/W) and photodetectivity (2.12 × 10<sup>13</sup> Jones). These results highlighted solid-ionic memory for building up multifunctional electronic and optoelectronic devices.
SAC: Semantic Attention Composition for Text-Conditioned Image Retrieval (2020)

The ability to efficiently search for images is essential for improving the user experiences across various products. Incorporating user feedback, via multi-modal inputs, to navigate visual search can help tailor retrieved results to specific user queries. We focus on the task of text-conditioned image retrieval that utilizes support text feedback alongside a reference image to retrieve images that concurrently satisfy constraints imposed by both inputs. The task is challenging since it requires learning composite image-text features by incorporating multiple cross-granular semantic edits from text feedback and then applying the same to visual features. To address this, we propose a novel framework SAC which resolves the above in two major steps: "where to see" (Semantic Feature Attention) and "how to change" (Semantic Feature Modification). We systematically show how our architecture streamlines the generation of text-aware image features by removing the need for various modules required by other state-of-art techniques. We present extensive quantitative, qualitative analysis, and ablation studies, to show that our architecture SAC outperforms existing techniques by achieving state-of-the-art performance on 3 benchmark datasets: FashionIQ, Shoes, and Birds-to-Words, while supporting natural language feedback of varying lengths.
Development of BLightER, a cost sensitive, high performance FMCW radar (2004)

This paper describes the nniqne design methodology used by Plextek to design BLightER, a portable and lightweight, low EOSI radar. By designing the radar using components and technologies that offer significant cost and availability advantages, a highly cmteffective radar design has been achieved.
Motor cortex and hand motor skills: Structural compliance in the human brain (1997)

Recent studies in humans and nonhuman primates have shown that the functional organization of the human sensorimotor cortex changes following sensory stimulation or following the acquisition of motor skills. It is unknown whether functional plasticity in response to the acquisition of new motor skills and the continued performance of complicated bimanual movements for years is associated with structural changes in the organization of the motor cortex. Professional musicians, especially keyboard and string players, are a prototypical group for investigating these changes in the human brain. Using magnetic resonance images, we measured the length of the posterior wall of the precentral gyrus bordering the central sulcus (intrasulcal length of the precentral gyrus, ILPG) in horizontal sections through both hemispheres of right-handed keyboard players and of an age- and handedness-matched control group. Lacking a direct in vivo measurement of the primary motor cortex in humans, we assumed that the ILPG is a measure of the size of the primary motor cortex. Left-right asymmetry in the ILPG was analyzed and compared between both groups. Whereas controls exhibited a pronounced left-larger-than-right asymmetry, keyboard players had more symmetrical ILPG. The most pronounced differences in ILPG between keyboard players and controls were seen in the most dorsal part of the presumed cortical hand representation of both hemispheres. This was especially true in the nondominant right hemispheres. The size of the ILPG was negatively correlated with age of commencement of musical training in keyboard players, supporting our hypothesis that the human motor cortex can exhibit functionally induced and long-lasting structural adaptations.
Dysmenorrhea. (2005)

Dysmenorrhea is the leading cause of recurrent short-term school absence in adolescent girls and a common problem in women of reproductive age. Risk factors for dysmenorrhea include nulliparity, heavy menstrual flow, smoking, and depression. Empiric therapy can be initiated based on a typical history of painful menses and a negative physical examination. Nonsteroidal anti-inflammatory drugs are the initial therapy of choice in patients with presumptive primary dysmenorrhea. Oral contraceptives and depo-medroxyprogesterone acetate also may be considered. If pain relief is insufficient, prolonged-cycle oral contraceptives or intravaginal use of oral contraceptive pills can be considered. In women who do not desire hormonal contraception, there is some evidence of benefit with the use of topical heat; the Japanese herbal remedy toki-shakuyaku-san; thiamine, vitamin E, and fish oil supplements; a low-fat vegetarian diet; and acupressure. If dysmenorrhea remains uncontrolled with any of these approaches, pelvic ultrasonography should be performed and referral for laparoscopy should be considered to rule out secondary causes of dysmenorrhea. In patients with severe refractory primary dysmenorrhea, additional safe alternatives for women who want to conceive include transcutaneous electric nerve stimulation, acupuncture, nifedipine, and terbutaline. Otherwise, the use of danazol or leuprolide may be considered and, rarely, hysterectomy. The effectiveness of surgical interruption of the pelvic nerve pathways has not been established.
Range Safety Systems (2002)

The high kinetic and potential energy of a launch vehicle mandates there be a mechanism to minimize possible damage to provide adequate safety for the launch facilities, range, and, most importantly, the general public. The Range Safety System, sometimes called the Flight Termination System or Flight Safety System, provides the required level of safety. The Range Safety System section of the Avionics chapter will attempt to describe how adequate safety is provided, the system's design, operation, and it's interface with the rest of the launch vehicle.
Detours: binary interception of Win32 functions (1999)

Innovative systems research hinges on the ability to easily instrument and extend existing operating system and application functionality. With access to appropriate source code, it is often trivial to insert new instrumentation or extensions by rebuilding the OS or application. However, in today's world of commercial software, researchers seldom have access to all relevant source code.

We present Detours, a library for instrumenting arbitrary Win32 functions on x86 machines. Detours intercepts Win32 functions by re-writing target function images. The Detours package also contains utilities to attach arbitrary DLLs and data segments (called payloads) to any Win32 binary.

While prior researchers have used binary rewriting to insert debugging and profiling instrumentation, to our knowledge, Detours is the first package on any platform to logically preserve the un-instrumented target function (callable through a trampoline) as a subroutine for use by the instrumentation. Our unique trampoline design is crucial for extending existing binary software.

We describe our experiences using Detours to create an automatic distributed partitioning system, to instrument and analyze the DCOM protocol stack, and to create a thunking layer for a COM-based OS API. Micro-benchmarks demonstrate the efficiency of the Detours library.
Interventional Nephrology and Dialysis: Chronic Peritoneal Dialysis Catheters: Overview of Design, Placement, and Removal Procedures (2003)

The success of chronic peritoneal dialysis (PD) depends to a large extent on the success of the chronic PD access device. For the nephrologist placing and removing PD catheters, or for the nephrologist advising surgeons in this role, this article provides a review of designs of PD catheters and differences in function and complications, methods of insertion of PD catheters and relation to catheter outcomes, techniques for "burying" the external portion of the PD catheter and benefits of this technique, and techniques for removing PD catheters. As nephrologists become more closely involved in the creation, monitoring, and maintenance of access devices for end-stage renal disease (ESRD) patients, the successful function of these devices will increase. Nephrologists should make the critical decisions regarding the choice of access devices and methods for placement as they do for the choice to remove such access devices.
Kinetics of pyridine-catalyzed hydrolysis of chloropentaphenylcyclotriphosphonitrile (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of pyridine-catalyzed hydrolysis of chloropentaphenylcyclotriphosphonitrileCharles D. Schmulbach and V. R. MillerCite this: Inorg. Chem. 1968, 7, 11, 2189–2192Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/ic50069a003https://doi.org/10.1021/ic50069a003research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway (2013)

Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X](+) where M = Ru(II) or Os(II) and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells. Not only are the iodido complexes more potent than the chlorido analogues, but they are not cross-resistant with the clinical platinum drugs cisplatin and oxaliplatin. They are also more selective for cancer cells versus normal cells (fibroblasts) and show high accumulation in cell membranes. They arrest cell growth in G1 phase in contrast to cisplatin (S phase) with a high incidence of late-stage apoptosis. The iodido complexes retain potency in p53 mutant colon cells. All complexes activate caspase 3. In general, antiproliferative activity is greatly enhanced by low levels of the glutathione synthase inhibitor l-buthionine sulfoxime. The work illustrates how subtle changes to the design of low-spin d(6) metal complexes can lead to major changes in cellular metabolism and to potent complexes with novel mechanisms of anticancer activity.
Steady state analysis of coded cooperative networks with HARQ protocol (2009)

We consider a network with an arbitrary number of nodes, where transmission of data packet is enhanced by a medium access control protocol that allows cooperation among nodes and solves transmission failures by an automatic repeat request (ARQ) protocol. Nodes operate in half-duplex mode and may interfere with each other as no coordination is assumed. In this scenario, we first derive the outage probability for a given number of interfering nodes and then relate the interference level to the single node behavior. We analyze the network behavior with a steady state analysis that matches the number of interfering nodes with the number of ARQ retransmissions. Two alternatives for cooperation are considered: decode and forward (DF) cooperation and multiple input-single output (MISO) cooperation, where for each packet transmission either one node transmits at a given time or two cooperating nodes transmit simultaneously. In our steady state analysis we also include an opportunistic version of DF, where cooperation is activated only when the quality of the cooperator-destination link is better than that of the source-destination link. Moreover, we investigate cooperator selection based on its distance to the destination.
Nanoscale Mapping of Interfacial Electrical Transport in Graphene-MoS 2 Heterostructures with STEM-EBIC (2016)

Journal Article Nanoscale Mapping of Interfacial Electrical Transport in Graphene-MoS 2 Heterostructures with STEM-EBIC Get access Edward R White, Edward R White Department of Chemistry, Imperial College London, London SW7 2AZ, UK.Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California, 90095, USA. Search for other works by this author on: Oxford Academic Google Scholar Alexander Kerelsky, Alexander Kerelsky Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California, 90095, USA. Search for other works by this author on: Oxford Academic Google Scholar William A Hubbard, William A Hubbard Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California, 90095, USA. Search for other works by this author on: Oxford Academic Google Scholar Rohan Dhall, Rohan Dhall Department of Electrical Engineering, University of Southern California, Los Angeles, California, 90089, USA. Search for other works by this author on: Oxford Academic Google Scholar Stephen B Cronin, Stephen B Cronin Department of Electrical Engineering, University of Southern California, Los Angeles, California, 90089, USA. Search for other works by this author on: Oxford Academic Google Scholar Matthew Mecklenburg, Matthew Mecklenburg Center for Electron Microscopy and Microanalysis, University of Southern California, Los Angeles, California, 90089, USA. Search for other works by this author on: Oxford Academic Google Scholar B C Regan B C Regan Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California, 90095, USA. Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 1552–1553, https://doi.org/10.1017/S1431927616008606 Published: 25 July 2016
[Pathway to care of people with first episode of schizophrenia, in Chile]. (2015)

Most of the patients had medical contacts for their psychotic symptoms, but their diagnosis were not made within that period, delaying the start of treatment. There is a need to develop strategies to improve diagnosis capabilities in these centers.
Tunneling microscope observation of a structural surface phase transition: Structure, fluctuations, and local effects (1993)

We study a reversible phase transition of one monolayer of Pb on a Ge(111) surface with a tunneling microscope over a temperature range from below to above the transition (\ensuremath{\sim}175 \ifmmode^\circ\else\textdegree\fi{}C). The controversial high temperature phase is actually a simple Pb-terminated 1\ifmmode\times\else\texttimes\fi{}1 structure. Below the transition temperature, Pb atoms are displaced from their ${\mathit{T}}_{1}$ positions and form trimers with \ensuremath{\surd}3 \ifmmode\times\else\texttimes\fi{} \ensuremath{\surd}3 periodicity. A fluctuating structure with patches of trimers can be resolved slightly above the transition temperature. The important effects of boundaries and domain size on the phase transformation are discussed.
The cold eye irrigation BSS solution used during phacoemulsification reduces post-surgery patients discomfort preventing the inflammation (2021)

Our study provided evidence supporting the efficacy of the treatment with cold irrigation solution on reduction of anterior chamber flare, pain and conjunctival hyperemia already at 1 day after phacoemulsification, suggesting that cooling procedure was fully effective at controlling early post-operative inflammation.
Interaction of Bacterial Membrane Vesicles with Specific Species and Their Potential for Delivery to Target Cells (2017)

Membrane vesicles (MVs) are secreted from a wide range of microbial species and transfer their content to other cells. Although MVs play critical roles in bacterial communication, whether MVs selectively interact with bacterial cells in microbial communities is unclear. In this study, we investigated the specificity of the MV-cell interactions and evaluated the potential of MVs to target bacterial cells for delivery. MV association with bacterial cells was examined using a fluorescent membrane dye to label MVs. MVs derived from the enterobacterium <i>Buttiauxella agrestis</i> specifically interacted with cells of the parent strain but interacted less specifically with those of other genera tested in this study. Electron microscopic analyses showed that MVs were not only attached on <i>B. agrestis</i> cells but also fused to them. The interaction energy, which was characterized by hydrodynamic diameter and zeta potential based on the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory, was significant low between MVs and cells in <i>B. agrestis</i>, compared to those between <i>B. agrestis</i> MVs and cells of other genera. Similar specific interaction was also occurred between <i>B. agrestis</i> MVs and cells of six other species belonging to <i>Buttiauxella</i> spp. <i>B. agrestis</i> harboring plasmid pBBR1MCS-1 secreted plasmid-containing MVs (p-MVs), and plasmid DNA in p-MVs was transferred to the same species. Moreover, antibiotic-associated MVs enabled effective killing of target species; the survival rate of <i>B. agrestis</i> was lower than those of <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> in the presence of gentamicin-associated MVs derived from <i>B. agrestis</i>. Altogether, we provide the evidence that MVs selectively interact with target bacterial cells and offer a new avenue for controlling specific bacterial species using bacterial MVs in microbial communities.
Shared output buffer‐type switching architecture with fair output port contention (1995)

Abstract This paper considers the shared output buffertype switching system as an architecture suited to the large‐scale ATM switching system. an architecture is proposed, which can solve the fair throughput assignment problem among the ports belonging to the same shared memory, which is a problem in sharing the output buffer. the proposed architecture realizes fair access to the destination port contained in the specified shared buffer, by sort processing and the address attachment, without using the random access contention unit to the buffer in the knockout switch. For the proposed architecture and the conventional shared output buffer‐type knockout switching system, the performances are compared by deriving the cell loss probability due to the output contention for each port. As a result, it is verified that the proposed architecture is better in terms of the realized cell loss probability. The performance of the switching system is evaluated by a computer stimulation when various buffering schemes are applied to the shared output buffer. Then it is shown that the fair throughput assignment among the considered output ports can be realized by combining the proposed architecture with an adequate buffering scheme.
Design and control of a bio-inspired soft wearable robotic device for ankle–foot rehabilitation (2014)

We describe the design and control of a wearable robotic device powered by pneumatic artificial muscle actuators for use in ankle-foot rehabilitation. The design is inspired by the biological musculoskeletal system of the human foot and lower leg, mimicking the morphology and the functionality of the biological muscle-tendon-ligament structure. A key feature of the device is its soft structure that provides active assistance without restricting natural degrees of freedom at the ankle joint. Four pneumatic artificial muscles assist dorsiflexion and plantarflexion as well as inversion and eversion. The prototype is also equipped with various embedded sensors for gait pattern analysis. For the subject tested, the prototype is capable of generating an ankle range of motion of 27° (14° dorsiflexion and 13° plantarflexion). The controllability of the system is experimentally demonstrated using a linear time-invariant (LTI) controller. The controller is found using an identified LTI model of the system, resulting from the interaction of the soft orthotic device with a human leg, and model-based classical control design techniques. The suitability of the proposed control strategy is demonstrated with several angle-reference following experiments.