gebhart/patrepeval huggingface dataset:
FPGA-based path-planning of high mobility rover for future planetary missions (2012)

Work in navigational autonomy for planetary exploration rovers has focused on achieving safe and efficient path-planning through unknown, rocky terrain. Computer vision is playing an important role in increasing autonomy of both spacecraft and robotic vehicles, however due to their increased computational complexity, they are rarely implemented onto conventional computing systems. This problem becomes far more severe whenever real-time constraints have also to be considered. This paper addresses progress on rover path planning for high mobility mars rover missions. More specifically, at SPARTAN project, a demonstrator is being developed that meets ESA's specifications for the problem of rover Localization. This problem accounts for the generation of location estimates. This process involves four distinct applications: Imaging, 3D-Reconstruction, Visual Odometry (VO) and Visual Simultaneous Localization and Map reconstruction (SLAM). On supporting these functions we developed a novel HW/SW co-design methodology that extracts parallelism in higher algorithmic level, and thus allows the simultaneous execution of computational intensive kernels on a FPGA device, while the control flow is maintained by a low-performance CPU. Experimental results show that our implementation achieves the scopes of SPARTAN project.
Zn2+‐induced Ca2+release via ryanodine receptors triggers calcineurin‐dependent redistribution of cortical neuronal Kv2.1 K+channels (2016)

Sublethal injurious stimuli in neurons induce transient increases in free intracellular Zn(2+) that are associated with regulating adaptive responses to subsequent lethal injury, including alterations in the function and localization of the delayed-rectifier potassium channel, Kv2.1. However, the link between intracellular Zn(2+) signalling and the observed changes in Kv2.1 remain undefined. In the present study, utilizing exogenous Zn(2+) treatment, along with a selective Zn(2+) ionophore, we show that transient elevations in intracellular Zn(2+) concentrations are sufficient to induce calcineurin-dependent Kv2.1 channel dispersal in rat cortical neurons in vitro, which is accompanied by a relatively small but significant hyperpolarizing shift in the voltage-gated activation kinetics of the channel. Critically, using a molecularly encoded calcium sensor, we found that the calcineurin-dependent changes in Kv2.1 probably occur as a result of Zn(2+) -induced cytosolic Ca(2+) release via activation of neuronal ryanodine receptors. Finally, we couple this mechanism with an established model for in vitro ischaemic preconditioning and show that Kv2.1 channel modulation in this process is also ryanodine receptor-sensitive. Our results strongly suggest that intracellular Zn(2+) -initiated signalling may represent an early and possibly widespread component of Ca(2+) -dependent processes in neurons.
Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells (2003)

Oxidized low-density lipoprotein (oxLDL) is known to induce apoptosis in endothelial cells, and this is believed to contribute to the progression of atherosclerosis. In the present study we made the novel observation that oxLDL-induced death of HMEC-1 cells is accompanied by activation of calpain. The mu-calpain inhibitor PD 151746 decreased oxLDL-induced cytotoxicity, whereas the general caspase inhibitor BAF (t-butoxycarbonyl-Asp-methoxyfluoromethylketone) had no effect. Also, oxLDL provoked calpain-dependent proteolysis of cytoskeletal alpha-fodrin in the HMEC-1 cells. Our observation of an autoproteolytic cleavage of the 80 kDa subunit of mu-calpain provided further evidence for an oxLDL-induced stimulation of calpain activity. The Bcl-2 protein Bid was also cleaved during oxLDL-elicited cell death, and this was prevented by calpain inhibitors, but not by inhibitors of cathepsin B and caspases. Treating the HMEC-1 cells with oxLDL did not result in detectable activation of procaspase 3 or cleavage of PARP [poly(ADP-ribose) polymerase], but it did cause polyubiquitination of caspase 3, indicating inactivation and possible degradation of this protease. Despite the lack of caspase 3 activation, oxLDL treatment led to the formation of nucleosomal DNA fragments characteristic of apoptosis. These novel results show that oxLDL initiates a calpain-mediated death-signalling pathway in endothelial cells.
Treatment of de novo acute myelogenous leukemia with recombinant granulocyte macrophage-colony-stimulating factor in combination with standard induction chemotherapy: Effect of granulocyte macrophage-colony-stimulating factor on white blood cell counts (1992)

GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of GM-CSF on peripheral blood AML blasts was associated with a rapid redistribution of leukemic blood cells and with an increase in "S-phase positive" cells. Standard induction chemotherapy ("3 + 7") following GM-CSF induced complete aplasia in 19/20 patients. In the same patients, rhGM-CSF (given after chemotherapy) was found to shorten the time of complete aplasia compared to historical controls whereas post-chemotherapy- and follow-up data suggest no significant differences for CCR and survival. Together, our studies show that GM-CSF can safely be administered to AML patients in combination with induction chemotherapy to recruit leukemic cells into the cell cycle.
β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices (2010)

Our data demonstrate that activation of both β1- and β2-receptors is neuroprotective and may offer mechanistic insights valuable for development of neuro-protective strategies in neonates.
IL-6-induced changes in synthesis of alpha 1-acid glycoprotein in human hepatoma Hep3B cells are distinctively regulated by monoclonal antibodies directed against different epitopes of IL-6 receptor (gp80). (1995)

The synthesis of the human acute-phase alpha 1-acid glycoprotein (AGP) is primarily controlled by IL-6 and IL-1 in liver cells. In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line. Two of the 4 MAbs used in this study, M164 and M195, identified 2 different epitopes involved in IL-6 binding and two others, M91 and M182, recognized epitopes not involved in IL-6 binding. Dose-response experiments indicated that up to 55% of AGP synthesis was inhibited by 10(5) ng/ml of MAbs 164 or 195 when Hep3B cells were treated by IL-6 for 48h. Kinetics of the inhibition of AGP synthesis after addition of anti-IL-6R indicated that the decrease of the IL-6-induced AGP synthesis by Hep3B cells was obtained immediately after the addition of the anti-IL-6R MAbs. Of the two MAbs not involved in IL-6 binding, M91 was unable to interfere with the IL-6-induced AGP synthesis whereas, surprisingly, M182 decreased it by about 25%. Since M182 was also able to interfere with the proliferative response of an IL-6 dependent plasma cell line, our results suggested that M182 may be directed to a structure involved in the IL-6/IL-6R gp130 complex formation.(ABSTRACT TRUNCATED AT 250 WORDS)
Ni(OH)2-free NiCu as a hydrogen evolution and oxidation electrocatalyst (2021)

In this manuscript, we investigate the role of the nickel surface oxidation and the use of additional reducing agent in the synthesis process in the electrochemical activity of NiCu electrocatalysts for hydrogen oxidation reaction and hydrogen evolution reaction. In addition, the role of the carbon support morphology is also investigated: two different supports, DENKA black and Ketjenblack with widely different properties (specific surface, proportion of low strain carbons, etc.) are studied, and no difference are observed in their electrochemical activity. However, the use 4-aminoantipyrine as a reducing agent resulted in a dramatic increase in non-oxidized Ni at the electrocatalyst’ surface, concomitant to a large increase in its activity for both the hydrogen evolution and oxidation.
Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging (2019)

Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging.
Construction of pH gradients in flow-injection analysis and their potential use for multielement analysis in a single sample bolus (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstruction of pH gradients in flow-injection analysis and their potential use for multielement analysis in a single sample bolusD. Betteridge and Bernard. FieldsCite this: Anal. Chem. 1978, 50, 4, 654–656Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ac50026a030https://doi.org/10.1021/ac50026a030research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Characterization of Chitosan-Based Novel Superabsorbent Hydrogel (2015)

2 Abstract: In this present research program,synthesis of a superabsorbent hydrogel (DHPC-GMA-g-PAAm) was carried out through a two-step reaction process. Water soluble chitosan (DHPC) was reacted first with glycidyl methacrylate (GMA) to produce DHPC-GMA and then acryl amide(AAM) and potassium peroxydisulphate(KPS) were added to promote the polymerization with DHPC-GMA to produce the final superabsorbent hydrogel DHPC-GMA-g-PAAm. FT-IR spectra indicated the structural changes in the materials and the results confirmed the successful incorporation of vinyl groups from GMA into the DHPC structure and strong interactions between DHPC-GMA and PAAm was observed. The effect of DHPC-GMA/AAm weight ratio was examined on the swelling behavior of the synthesized superabsorbent hydrogel and the highest water swelling percentage (about 1900%) was obtained within the experimental reaction conditions: DHPC-GMA/AAm weight ratio = 0.1, KPS = 0.02g and reaction temperature 65oC. The swelling mechanism indicates pseudo-second-order kinetic model with high water absorption uptake by the hydrogel. The changes in the superabsorbent hydrogel morphology with GMA, N-O-HP and DHPC-GMA/AAm weight ratio indicates close agreement with the hydrogels B, C and D swelling behavior. The results suggest that these hydrogels can be useful in biomedical, agricultural fields due to their greater swelling ability in water. Further they can be used as dye removal for Reactive Blue 2 (RB2) and Erichrome Black T (EBT) in this study. In this study, three different grafted copolymer materials labeled B, C and D with varying grafting percentages were compared as sorbents for removal of Reactive blue 2 and Erichrome black T and the experimental observations are summarized below: DHPC-GMA-g-PAAm with highest grafting percentage and efficiency (D- G%= 995 and E%= 99.5%) present highest sorption capacities for Erichrome black T (38.02mg/g) while sample B with lowest grafting percentage and efficiency (B- G%= 150 and E%= 49.8) present lowest sorption capacities for EBT (12.79mg/g). DHPC-GMA-g-PAAm with lowest grafting percentage and efficiency (B- G%= 150 and E%= 49.8) present highest sorption capacities for RB2 (58.14mg/g) while sample D with highest grafting percentage and efficiency (D-G%= 995 and E%= 99.5%) present lowest sorption capacities for RB2 (32.73mg/g). In the dyes mixture, the adsorption kinetics of the two dyes influence each other, competitive adsorption favors the dye EBT and the dynamic behavior for mixture of dyes adsorption onto DHPC-GMA-g-PAAM preferably obeyed pseudo-second-order-kinetics similarly to that of single dye sorption kinetics. The sorption rate was very fast for RB2 with lower adsorption capacity compared.
Managing the harvested energy in wireless sensor networks: A priority Geo/Geo/1/k approach with threshold (2022)

Wireless sensor networks face many challenges, the major one being energy. Batteries are the main source of energy for the sensor nodes. When the battery is depleted, it must either be charged or replaced. This may be expensive or impossible to do. Energy harvesting has been proposed as an alternative. The energy is harvested and then stored in a battery. However, even if the battery is not in use, it experiences current leakages. We study the performance of a single node, which has data packets and energy tokens. The energy that is harvested is kept in reserve as energy tokens in an energy buffer and utilised by the data packets for transmission. This paper investigates the impact of imposing a threshold on the token buffer of the system. The problem considered is managing the energy buffer by taking into account storage of energy, usage by the data packets and energy leakage. The proposed model considers the transmission of high and low priority data packets. To ensure that there are tokens available in the system to transmit the high-priority data packets in case the arrival rate of the low-priority data packets is too high at the expense of high priority data packets, a threshold is imposed on the token buffer. To illustrate our approach, a Geo/Geo/1/k system is modelled and finite Markov chain model tools are used to analyse it. Numerical examples, which show how performance measures such as the mean number of data packets and tokens in the system are affected by energy harvesting, leakage and threshold, are presented. From the results obtained we show that the model can be utilised in the analysis and control of a wireless sensor network, as it captures the usage and leakage of energy. A trade-off between threshold and rate of leakage exists.
Topological tradeoffs in autocatalytic metabolic pathways (2010)

Metabolic pathways in cells convert external food and resources into useful cell components and energy. In many cases the cell employs product inhibition to regulate and control these pathways. We investigate the performance of such regulation and control on certain autocatalytic pathways. Specifically, we examine how well the pathways can maintain the desired output concentrations in the presence of disturbances, such as perturbations in resources, enzyme concentrations and product demand. Using control theoretic tools, we show the effects of the pathway size, the reversibility of the intermediate reactions and the coupling of pathways through the consumption of intermediate metabolites on performance. In addition, we establish some necessary conditions on the existence of fixed points and their stability for such pathways.
Three new members of the RNP protein family inXenopus (1993)

Many RNP proteins contain one or more copies of the RNA recognition motif (RRM) and are thought to be involved in cellular RNA metabolism. We have previously characterized in Xenopus a nervous system specific gene, nrp1, that is more similar to the hnRNP A/B proteins than to other known proteins (K. Richter, P. J. Good, and I. B. Dawid (1990), New Biol. 2, 556-565). PCR amplification with degenerate primers was used to identify additional cDNAs encoding two RRMs in Xenopus. Three previously uncharacterized genes were identified. Two genes encode hnRNP A/B proteins with two RRMs and a glycine-rich domain. One of these is the Xenopus homolog of the human A2/B1 gene; the other, named hnRNP A3, is similar to both the A1 and A2 hnRNP genes. The Xenopus hnRNP A1, A2 and A3 genes are expressed throughout development and in all adult tissues. Multiple protein isoforms for the hnRNP A2 gene are predicted that differ by the insertion of short peptide sequences in the glycine-rich domain. The third newly isolated gene, named xrp1, encodes a protein that is related by sequence to the nrp1 protein but is expressed ubiquitously. Despite the similarity to nuclear RNP proteins, both the nrp1 and xrp1 proteins are localized to the cytoplasm in the Xenopus oocyte. The xrp1 gene may have a function in all cells that is similar to that executed by nrp1 specifically within the nervous system.
TOWARDS AUTOMATIC CONTENT TAGGING - Enhanced Web Services in Digital Libraries using Lexical Chaining (2008)

This paper proposes a web-based application which combines social tagging, enhanced visual representation of a document and the alignment to an open-ended social ontology. More precisely we introduce on the one hand an approach for automatic extraction of document related keywords for indexing and representing document content as an alternative to social tagging. On the other hand a proposal for automatic classification within a social ontology based on the German Wikipedia category taxonomy is proposed. This paper has two main goals: to describe the method of automatic tagging of digital documents and to provide an overview of the algorithmic patterns of lexical chaining that can be applied for topic tracking and –labelling of digital documents.
Reproducibility of exhaled nitric oxide measurements in overweight and obese adults (2014)

We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices.
Car Driving Status and Living Arrangement Associated with Sarcopenia among Rural Japanese Older Adults: A Cross-Sectional Study (2021)

Ensuring mobility after driving cessation is an important public health issue to prevent functional limitations, but this issue is still not fully understood in rural settings. The aim of this study was to test the hypothesis that being a non-driver and living alone is associated with a greater risk of sarcopenia among the community-dwelling elderly in rural Japanese areas. This study was conducted in 2018 and data from 738 participants were used. Sarcopenia was assessed by measuring walking speed, handgrip strength, and skeletal muscle mass. Car driving status and living arrangement were collected using self-reported questionnaires and face-to-face interviews. Four groups were set to determine combined conditions of car driving status and living arrangement. Logistic regression analysis was performed to estimate the odds ratio (OR) and a 95% confidence interval of sarcopenia after adjustment for confounding factors. Compared with the reference group (driver and living with others), the OR of sarcopenia was significantly higher in the non-driver and living alone group (OR = 2.21; 95% confidence interval, 1.02-4.80). Our findings suggest that the consideration of both driving status and living arrangement are important in the formulation of public health strategies to prevent sarcopenia in rural Japanese areas.
Construction of a Sorbitol-Based Vector for Expression of Heterologous Proteins in Saccharomyces cerevisiae (1998)

A new inducible yeast expression vector, pXS7, was constructed by using the promoter and terminator sequences from the Saccharomyces cerevisiae SOR1 gene, which codes for the sorbitol dehydrogenase protein. We cloned the coding sequence of the Saccharomyces YEF3 gene in this vector and demonstrated an increase in YEF3 protein levels when cells were grown in the presence of the sugar sorbitol.
An objective approach to regional wastewater treatment planning (2002)

This research program was aimed at developing an objective methodology for water quality management on a river basin scale. To that end, a mathematical model has been formulated to determine the best configuration of wastewater treatment plants consistent with either fixed‐emission standards or prescribed river quality objectives. It will, of course, be appreciated that the latter case is considerably more difficult since this involves not only site selection but also waste load allocation. In the case of waste load allocation it was first necessary to use a process‐based river water quality simulation model to predict the impact of different combinations of effluent discharge standards on the river. For reasons of computational efficiency an artificial neural network was employed to replicate the process‐based model, which was then used in conjunction with a genetic algorithm to determine both the best sites and individual effluent discharge standards, subject to meeting the required river water quality. The overall model has been applied to the upper Thames basin in southern England, initially for site selection alone and then for site selection with waste load allocation. The results show that the genetic algorithm performs well for both options, thereby providing an efficient means of planning wastewater treatment on a regional basis.
A Turbidity Method for the Measurement of the Particle Size Distribution of Sols (2003)

A turbidity method, which is based on the Mie theory of light scattering of a single particle, is used to measure the particle size distribution of polystyrene latex. The measuring system consists of a common visible light spectrometer and selfdeveloped computer software. The measured number average diameter of sol particles is within the range of experimental error compared with that obtained by SEM, so is the mass average diameter compared with the hydrodynamic diameter measured by dynamic laser scattering method.
Duplex Ultrasound Screening for Deep Vein Thrombosis in Asymptomatic Trauma Patients: A Survey of Individual Trauma Surgeon Opinions and Current Trauma Center Practices (2011)

There are wide variations in trauma surgeons' opinions and trauma centers' practices regarding duplex ultrasound screening for DVT in asymptomatic trauma patients. This variability combined with the fact that performing more duplex ultrasounds finds more DVTs may influence reported DVT rates. DVT rates alone are biased and not reflective of true quality of trauma care.