gebhart/patrepeval huggingface dataset:
Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells (2005)

Although the beta2-adrenergic receptor (beta2AR) is the most extensively characterized G-protein-coupled receptor (GPCR), the effects of beta-agonists on T-cell subtype function remain poorly understood. In contrast to studies suggesting lack of beta2AR expression on type 2 T cells, we demonstrate that type 2 interleukin-13+ (IL-13+) T cells (CD4+ or CD8+) in human peripheral blood lymphocytes (PBLs) can respond directly to beta-agonist, with effects including induction of protein kinase A (PKA) activity and associated inhibition of CD3-stimulated CD25 expression; CD3-stimulated IL-13, interferon-gamma (IFN-gamma), and IL-2 production; and p38 mitogen-activated protein kinase (MAPK) phosphorylation. PGE2 was more efficacious than beta-agonist in activating PKA and inhibiting cytokine production. beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions. Differential regulation of PMA-stimulated p38, p42/p44, and NF-kappaB explained the capacity of PGE2 and beta-agonist to inhibit IFN-gamma but not IL-13 production. The inhibition of CD3 + CD28-stimulated IL-13 production by both beta-agonist and PGE2 was reversed at low agonist concentrations, resulting in enhanced IL-13, but not IFN-gamma or IL-2, production. These findings identify direct effects of beta2AR activation on T-cell subtypes and suggest a complex role for GPCRs and PKA activity in modulating T-cell functions.
Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization (2015)

Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine ( rì běn hàn yī) and traditional Chinese medicine (TCM; zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization.
Ubiquitous computing goes mobile (2001)

article Share on Ubiquitous computing goes mobile Author: Jean Scholtz National Institute of Standards and Technology (NIST) National Institute of Standards and Technology (NIST)View Profile Authors Info & Claims ACM SIGMOBILE Mobile Computing and Communications ReviewVolume 5Issue 3July 2001pp 32–38https://doi.org/10.1145/584051.584054Published:01 July 2001Publication History 11citation1,560DownloadsMetricsTotal Citations11Total Downloads1,560Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis (2016)

Nonalcoholic steatohepatitis (NASH) is an inflammatory lipotoxic disorder, but how inflammatory cells are recruited and activated within the liver is still unclear. We previously reported that lipotoxic hepatocytes release CXCL10-enriched extracellular vesicles, which are potently chemotactic for cells of the innate immune system. In the present study, we sought to determine the innate immune cell involved in the inflammatory response in murine NASH and the extent to which inhibition of the chemotactic ligand CXCL10 and its cognate receptor CXCR3 could attenuate liver inflammation, injury and fibrosis. C57BL/6J CXCL10(-/-), CXCR3(-/-) and wild type (WT) mice were fed chow or high saturated fat, fructose, and cholesterol (FFC) diet. FFC-fed CXCL10(-/-) and WT mice displayed similar weight gain, metabolic profile, insulin resistance, and hepatic steatosis. In contrast, compared to the WT mice, FFC-fed CXCL10(-/-) mice had significantly attenuated liver inflammation, injury and fibrosis. Genetic deletion of CXCL10 reduced FFC-induced proinflammatory hepatic macrophage infiltration, while natural killer cells, natural killer T cells, neutrophils and dendritic cells hepatic infiltration were not significantly affected. Our results suggest that CXCL10(-/-) mice are protected against diet-induced NASH, in an obesity-independent manner. Macrophage-associated inflammation appears to be the key player in the CXCL10-mediated sterile inflammatory response in murine NASH.
Sclerotherapy of Varicose and Telangiectatic Leg Veins: Minimal Sclerosant Concentration of Hypertonic Saline and Its Relationship to Vessel Diameter (1991)

The author reports the results of a double-blind, paired-comparison study using saline sclerosant plus or minus heparin additive. The study was designed to elucidate the effects of increasing concentrations of hypertonic saline with regard to vessel diameter, clinical efficacy, complications, and discomfort. Six hundred women with bilaterally symmetrical starburst telangiectasias or varicose veins were entered into the study. Sodium chloride 11.7% appeared to be the minimal sclerosant concentration of saline that produced the most effective vein sclerosis of vessels of less than 8 mm in diameter, while producing the least morbidity. The optimal concentration of the sclerosant may vary with the diameter of the vessels under therapeutic consideration.
New Prenylated Flavanones fromErythrina abyssinicawith Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity (2009)

As the insulin and leptin signaling pathway can be regulated by PTP1B, it has been suggested that compounds that reduce PTP1B activity or expression levels can be used for treating type 2 diabetes and obesity. In the course of our screening efforts on new PTP1B inhibitors, six new flavanones ( 1- 6) with dihydrofuran moiety and two known flavanones ( 7 and 8) were isolated from the stem bark of Erythrina abyssinica (Leguminosae). Their structures were elucidated on the basis of spectroscopic (including UV, CD, MS, 1D, and 2D NMR) and physicochemical analyses. With the exception of 3 and 5, the compounds inhibited PTP1B activity in an IN VITRO assay with IC (50) values ranging from 15.2 +/- 1.2 to 19.6 +/- 2.3 microM, whereas RK-682 as a positive control displayed an IC (50) value of 4.7 +/- 0.5 microM.
IChemPIC: A Random Forest Classifier of Biological and Crystallographic Protein–Protein Interfaces (2015)

Protein-protein interactions are becoming a major focus of academic and pharmaceutical research to identify low molecular weight compounds able to modulate oligomeric signaling complexes. As the number of protein complexes of known three-dimensional structure is constantly increasing, there is a need to discard biologically irrelevant interfaces and prioritize those of high value for potential druggability assessment. A Random Forest model has been trained on a set of 300 protein-protein interfaces using 45 molecular interaction descriptors as input. It is able to predict the nature of external test interfaces (crystallographic vs biological) with accuracy at least equal to that of the best state-of-the-art methods. However, our method presents unique advantages in the early prioritization of potentially ligandable protein-protein interfaces: (i) it is equally robust in predicting either crystallographic or biological contacts and (ii) it can be applied to a wide array of oligomeric complexes ranging from small-sized biological interfaces to large crystallographic contacts.
The Design, Structure, and Therapeutic Application of Matrix Metalloproteinase Inhibitors (2001)

Matrix metalloproteinases (MMPs) are a family of zinc-containing enzymes involved in the degradation and remodeling of extracellular matrix proteins. The activities of these enzymes are well regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). Chronic stimulation of MMP activities due to an imbalance in the levels of MMPs and TIMPs has been implicated in the pathogenesis of a variety of diseases such as cancer, osteoarthritis, and rheumatoid arthritis. Thus, MMP inhibitors are expected to be useful for the treatment of these disorders. This article reviews briefly the biochemistry of MMPs and evidence for their pathogenic roles using molecular biology approaches. Biomolecular structures used in the design of MMP inhibitors are thoroughly covered. Major emphasis is on recently published potent, small molecular weight MMP inhibitors and their pharmacological properties. Finally, available clinical results of compounds in development are summarized.
Selective Localization of Multiwalled Carbon Nanotubes in Poly(ε-caprolactone)/Polylactide Blend (2009)

Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work, we used functionalized multiwalled carbon nanotube (MWCNT) to control the morphology of immiscible PCL/PLA blend. The ternary PCL/PLA/MWCNTs composites were hence prepared by melt mixing for the morphology and the properties investigation. It is interesting to find that the functionalized MWCNTs are selectively dispersed in the matrix PCL phase and on the interface between two polymer phases, leading to simultaneous occurrence of thermodynamically and kinetically driven compatibility. Those interface-localized MWCNTs prevent coalescence of the discrete domains and enhance the phase interfacial adhesion as well. As a result, the phase morphology of the ternary composites is improved remarkably in contrast to that of the blank PCL/PLA blend. Owing to that unique selective interface-localization and improved phase morphology, the ternary composites present far lower rheological and conductive percolation thresholds than those of the binary composites, and also present extraordinary mechanical properties even at very low loading levels of the MWCNTs. Therefore, the amphiphilic MWCNTs are believed to act as the reinforcements as well as the compatibilizer in the immiscible PCL/PLA blend.
Modeling of Diffusion in Ellipsoidal Solids: A Simplified Approach (2004)

Abstract A three-dimensional model was applied to rigorously interpret the diffusion phenomena in ellipsoidal solids. The numerical solution of the diffusion equation was obtained by the finite difference method for ellipsoids of various shape factors. Due to its complexity for practical use, the spheroidal model (two-dimensional model) was utilized as a better alternative. In comparison with the numerical results generated by the three-dimensional model, the spheroidal model still fails to give good predictions in some cases, although it was assumed to have the same volume and surface area (i.e., same shape factor) as that of the ellipsoidal model. Consequently, a simplified approach was developed with satisfactory predictions, that is to apply a one-dimensional model to solve the diffusion problem with equivalent diameter as well as equivalent liquid diffusivity, which is a function of the intrinsic diffusivity and geometry factor.
Nonlinear effective permittivity of field grading composite dielectrics (2018)

Field grading composite dielectrics with good nonlinear electrical properties can function as smart materials for electrical field control in a high-voltage apparatus. Besides the well-documented nonlinear conducting behavior, the field-dependent effective permittivity of field grading composites were also reported; however, in-depth research on the mechanism and influencing factors of this nonlinear permittivity are absent. This paper theoretically discusses the origin of the nonlinear effective permittivity, and the mechanism is illustrated through the waveform analysis of the nonlinear response of ZnO microvaristor/silicone rubber composites under a pure AC field. The field-dependent effective permittivity and loss property of the ZnO composites are measured by a dielectric spectrometer in both DC and AC fields under different frequencies. Through comparison of measurement results and theoretical models, the influence of the filler concentration, frequency, and time domain characteristics of the applied field on the nonlinear permittivity of the field grading composites are well explained. This paper provides insight into the nonlinear permittivity of field grading composites, and will be helpful for further tuning the performance of field grading composites.
Curtobacterium flaccumfaciens pv. beticola, A New Pathovar of Pathogens in Sugar Beet (2007)

Bacterial leaf spot of sugar beet was first discovered in 1995 in Inner Mongolia of China. The pathogen was shown to be a bacterium with properties of gram-positive bacteria: small irregular rods, lateral flagella, aerobic, and catalase-positive. The colonies of sugar beet strains produced a pale-yellow pigment. The optimum temperature for the bacteria to grow was 24 to 27°C. The bacteria could utilize a wide range of organic compounds, including hydrolyzed casein, starch, esculin and Tween 80, and released H<sub>2</sub>S from cysteine, cystine, and Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub>·5H<sub>2</sub>O, but could not produce urease, oxidase, or indole. The cell wall peptidoglycan was based on ornithine (type B2β). The predominant menaquinone was MK-9. Polar lipids contained several glycosyldiacyl-glycerols. The DNA G+C content of a type strain of the new pathovar, T30<sup>T</sup>, was 67.5%. DNA-DNA homology between T30<sup>T</sup> and Curtobacterium flaccumfaciens pv. flaccumfaciens (International Collection of Micro-Organisms from Plants, New Zealand [ICMP] 2584) was 70.1%. The new pathovar and C. flaccumfaciens pv. flaccumfaciens had 99.9% identity in DNA sequence of 16S rRNA. Close genetic relatedness was observed for the representatives of the species Curtobacterium flaccumfaciens, but a low level of similarity between the different pathovars was found. Based on these physiological, biochemical, chemotaxonomic, phylogenetic, and genetic characteristics, we demonstrate that the pathogen represents a new pathovar of C. flaccumfaciens, for which we propose the name Curtobacterium flaccumfaciens pv. beticola pv. nov. The type strain is T30<sup>T</sup> (=ATCC BAA-144<sup>T</sup>).
Abstract P19 (2015)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Fundamento: A hipertensão pulmonar é associada ao pior prognóstico no pós-transplante cardíaco. O teste de reatividade pulmonar com Nitroprussiato de Sódio (NPS) está associado a elevados índices de hipotensão arterial sistêmica, disfunção ventricular do enxerto transplantado e elevadas taxas de desqualificação para o transplante. Objetivo: Neste estudo, objetivou-se comparar os efeitos do Sildenafil (SIL) e NPS sobre variáveis hemodinâmicas, neuro-hormonais e ecocardiográficas durante teste de… (2012)

Background: Pulmonary hypertension is associated with a worse prognosis after cardiac transplantation. The pulmonary hypertension reversibility test with sodium nitroprusside (SNP) is associated with a high rate of systemic arterial hypotension, ventricular dysfunction of the transplanted graft and high rates of disqualification from transplantation. Objective: This study was aimed at comparing the effects of sildenafil (SIL) and SNP on hemodynamic, neurohormonal and echocardiographic variables during the pulmonary reversibility test. Methods: The patients underwent simultaneously right cardiac catheterization, echocardiography, BNP measurement, and venous blood gas analysis before and after receiving either SNP (1 – 2 µg/kg/min) or SIL (100 mg, single dose). Results: Both drugs reduced pulmonary hypertension, but SNP caused a significant systemic hypotension (mean blood pressure - MBP: 85.2 vs. 69.8 mm Hg; p < 0.001). Both drugs reduced cardiac dimensions and improved left cardiac function (SNP: 23.5 vs. 24.8%, p = 0.02; SIL: 23.8 vs. 26%, p < 0.001) and right cardiac function (SIL: 6.57 ± 2.08 vs. 8.11 ± 1.81 cm/s, p = 0.002; SNP: 6.64 ± 1.51 vs. 7.72 ± 1.44 cm/s, p = 0.003), measured through left ventricular ejection fraction and tissue Doppler, respectively. Sildenafil, contrary to SNP, improved venous oxygen saturation, measured on venous blood gas analysis. Conclusion: Sildenafil and SNP are vasodilators that significantly reduce pulmonary hypertension and cardiac geometry, in addition to improving biventricular function. Sodium nitroprusside, contrary to SIL, was associated with systemic arterial hypotension and worsening of venous oxygen saturation. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0)
Combined Pathologies in FTLD-TDP Types A and C (2018)

This study investigated the presence of combined pathologies in a large cohort of autopsies that show a primary pathologic diagnosis of phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP), the majority of which portrayed clinical phenotypes consistent with primary progressive aphasia or behavioral variant frontotemporal dementia (bvFTD). Thirty-eight cases with FTLD-TDP (30 type-A and 8 type-C) were identified to determine characteristic differences between cases with and without combined pathologies. Findings indicated that combined pathologies co-occur with FTLD-TDP type-A at a high frequency (50%)-greater than when compared to FTLD-TDP type-C cases (12.5%). Those with FTLD-TDP type-A and combined pathologies showed significantly longer lifespans (p < 0.05), and longer disease durations (p < 0.05), than those with only FTLD-TDP type-A. Cases with FTLD-TDP type-A and known genetic mutations tended not to show combined pathology. Those with the GRN mutation and FTLD-TDP type-A showed a significantly younger age of onset (p < 0.05) and younger age at death (p < 0.01) compared to noncarriers. In 1 bvFTD case, we highlight the rare presence of "triple" FTLD-TDP type-A, FTLD-tau, and Alzheimer pathology. The ante- and post-mortem features associated with combined pathologies in FTLD-related disorders are of useful consideration in the stratification of patients to drug trials, and in the development of therapeutic targets for FTLD.
Table S4 from Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial (2023)

&lt;p&gt;Representativeness of Study Participants&lt;/p&gt;
Autonomous indoor robot navigation using a sketch interface for drawing maps and routes (2016)

Hand-Drawn sketches are natural means by which abstract descriptions of environments can be provided. They represent weak prior information about the scene, thereby enabling a robot to perform autonomous navigation and exploration when a full metrical description of the environment is not available beforehand. In this paper, we present an extensive evaluation of our navigation system that uses a sketch interface to allow the operator of a robot to draw a rough map of an indoor environment as well as a desired trajectory for the robot to follow. We employ a theoretical framework for sketch interpretation, in which associations between the sketch and the real world are modeled as local deformations of a suitable metric manifold. We investigate the effectiveness of our system and present empirical results from a set of experiments in real-world scenarios, focusing both on the navigation capabilities and the usability of the interface.
ChemInform Abstract: Organometallic Coordination Chemistry of Aluminum. Synthesis and Molecular Structure of (Al(CH3))2(C8H20N6)(Al(CH3)2)2: A Novel Example of a Neutral Organoaluminum Complex Containing Two Five‐Coordinate Aluminum Atoms in Square Pyramidal Environments. (1988)

Abstract The reaction of the triamine (I) with an excess of AlMe 3 (II) yields a quantitative amount of the title complex (III).
Evaluation of Sustainable Structural Concrete Using Recycled Aggregate and Aramid Fiber Sheet (2016)

The purpose of this study was to evaluate the flexural performance of recycled aggregate RC beam reinforced with aramid fiber sheets. Compressive strength of concrete using recycled aggregate is generally similar or slightly lower than normal concrete. To improve the compressive strength, aramid fiber sheets have been used in this study. This study examines the structural behavior of concrete beams prepared with recycled aggregate and strengthened aramid fiber sheets at varying locations. One concrete beam as a control specimen, that is prepared with 30 percent recycled aggregate and 70 percent natural aggregate, has been tested, and 3 more strengthened beams (bottom, bottom and sides, bottom and both ends with U-shaped strengthened beams) are tested. The ultimate loads have increased by 38.01%, 39.88%, and 100.79% for bottom, bottom and sides, bottom and both ends with U-shaped strengthened beams. The ductility ratios are 2.75~6.20 for strengthened beams. The experimental results showed that the strengthening system with U-shaped band controls the premature debonding and provides a more ductile failure mode than the strengthening system without U-shaped bands. It can be found that the ultimate strength of H40-RGA30-BS specimen based on load-deflection curves shows most promising result. The experimental results are compared with the analytical results of nonlinear flexural behaviors for strengthened reinforced recycled aggregate concrete beam.
One-electron oxidation of DNA: thymine versus guanine reactivity (2010)

One-electron oxidation of anthraquinone (AQ)-linked DNA oligonucleotides containing A/T base pairs with repeating TT steps results in the distance-dependent reaction of the resulting radical cation and base damage at the TT steps that is revealed by subsequent reaction as strand cleavage. However, the inclusion of a remote guanine or GG step inhibits the reaction at thymine and results in predominant reaction at the guanine bases. For the oligomers examined in this work, the results reveal that the specific sequence of nucleobases determines the distance dependence, location of reaction and the efficiency of radical cation migration. In particular, a sequence of A/T base pairs can behave either as a trap, shuttle or barrier, depending on the context of the entire oligomer. The A/T sequences act as a shuttle when reaction occurs at a remote G or GG step and the same sequence of A/T bases acts as a barrier when there is more than one GG step in the sequence. In contrast, the A/T steps act as a trap in sequences that lack guanines.