gebhart/patrepeval huggingface dataset:
Testosterone Administration Suppresses Adiponectin Levels in Men (2005)

ABSTRACT: Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes and is thought to influence insulin sensitivity. In this study, we sought to determine whether experimental alterations in serum T change adiponectin levels in normal men. We measured adiponectin levels in 28 healthy men ages 18–35 years before and during treatment with a potent gonadotropin‐releasing‐hormone (GnRH) antagonist, acyline. Decreased T levels led to increased serum adiponectin within 7 days; maximal adiponectin levels were reached on day 21 (baseline 8.6 ± 0.9 compared with 12.2 ± 1.0 μg/mL on day 21, P &lt; .05) and persisted through day 30, despite no significant changes in body mass index (BMI) and an increase in leptin. The addition of T to acyline, maintaining serum T levels within the normal range, prevented the increase in adiponectin following acyline alone. In a second study, 25 men aged 55–85 years were treated with 3 weeks of high‐dose T (testosterone enanthate [TE], 600 mg/wk intramuscularly). With high serum T levels, adiponectin levels decreased significantly by day 21 of treatment (baseline 14.3 ± 1.9 compared with 10.8 ± 1.5 μg/mL, P &lt; .05 vs baseline and placebo), BMI slightly increased, and leptin levels were decreased. We conclude that adiponectin levels increase within days of experimental T deficiency in normal men, and the increase in adiponectin is prevented by T replacement. Furthermore, supraphysiologic T administration results in decreased adiponectin levels. Our data support the hypothesis that T, its metabolites, or both directly suppress adipocyte production of adiponectin.
A super-Earth orbiting near the inner edge of the habitable zone around the M4.5 dwarf Ross 508 (2022)

Abstract We report the near-infrared radial velocity (RV) discovery of a super-Earth planet on a 10.77 d orbit around the M4.5 dwarf Ross 508 (Jmag = 9.1). Using precision RVs from the Subaru Telescope IRD (InfraRed Doppler) instrument, we derive a semi-amplitude of $3.92^{+0.60}_{-0.58}\:\mbox{m}\:{\mbox{s}^{-1}}$, corresponding to a planet with a minimum mass $m \sin i = 4.00^{+0.53}_{-0.55}\, M_{\oplus }$. We find no evidence of significant signals at the detected period in spectroscopic stellar activity indicators or MEarth photometry. The planet, Ross 508 b, has a semi-major axis of $0.05366^{+0.00056}_{-0.00049}\:$au. This gives an orbit-averaged insolation of ≈1.4 times the Earth’s value, placing Ross 508 b near the inner edge of its star’s habitable zone. We have explored the possibility that the planet has a high eccentricity and its host is accompanied by an additional unconfirmed companion on a wide orbit. Our discovery demonstrates that the near-infrared RV search can play a crucial role in finding a low-mass planet around cool M dwarfs like Ross 508.
A novel bit stuffing technique for Controller Area Network (CAN) protocol (2014)

Control area network (CAN) is a two-wired, half duplex, high-speed network system that is far superior to conventional serial communication protocol such as RS232 in terms of functionality and reliability. CAN implementation are also cost effective. All CAN controllers in a network operate at the same frequency for safe and proper data transfer. As CAN uses Non Return to Zero (NRZ) bit encoding, long sequence of same polarity bit will cause the losses of synchronization among the CAN controller. CAN provides an effective mechanism for clock synchronization known as “bit-stuffing”. It is very difficult to predict the precise transmission time of message which leads to an adverse impact on many time critical applications. To mitigate above problem different “bit-stuffing” techniques such as XOR masking and Software Bit Stuffing (SBS) is available in the literature. In this paper a novel alternative method known as Eight-to-Eleven Modulation (EEM) technique is used for “bit-stuffing” and a comparison is brought with existing SBS technique and the superior features of EEM are established. The proposed technique is validated through FPGA implementation.
Classifying Time Series Using Local Descriptors with Hybrid Sampling (2015)

Time series classification (TSC) arises in many fields and has a wide range of applications. Here, we adopt the bag-of-words (BoW) framework to classify time series. Our algorithm first samples local subsequences from time series at feature-point locations when available. It then builds local descriptors, and models their distribution by Gaussian mixture models (GMM), and at last it computes a Fisher Vector (FV) to encode each time series. The encoded FV representations of time series are readily used by existing classifiers, e.g., SVM, for training and prediction. In our work, we focus on detecting better feature points and crafting better local representations, while using existing techniques to learn codebook and encode time series. Specifically, we develop an efficient and effective peak and valley detection algorithm from real-case time series data. Subsequences are sampled from these peaks and valleys, instead of sampled randomly or uniformly as was done previously. Then, two local descriptors, Histogram of Oriented Gradients (HOG-1D) and Dynamic time warping-Multidimensional scaling (DTW-MDS), are designed to represent sampled subsequences. Both descriptors complement each other, and their fused representation is shown to be more descriptive than individual ones. We test our approach extensively on 43 UCR time series datasets, and obtain significantly improved classification accuracies over existing approaches, including NNDTW and shapelet transform.
3D Interaction with Virtual Objects in Real Water (2019)

The objective of this research was to evaluate and compare perceived fatigue and usability of 3D user interfaces in and out of the water. Virtual Reality (VR) in the water has several potential applications, such as aquatic physical rehabilitation, where patients are typically standing waist or shoulder deep in a pool and performing exercises in the water. However, there have been few works that developed waterproof VR/AR systems and none of them have assessed fatigue, which has previously been shown to be a drawback in many 3D User Interfaces above water. This research presents a novel prototype system for developing waterproof VR experiences and investigates the effect of submersion in water on fatigue as compared to above water. Using a classic selection and docking task, results suggest that being underwater had no significant effect on performance, but did reduce perceived fatigue, which is important for aquatic rehabilitation. Previous 3D interaction methods that were once thought to be too fatiguing might still be viable in water.
Additions and Corrections - Marine Natural Products: Parguerol, Deoxyparguerol, and Isoparguerol. New Brominated Diterpenes with Modified Pimarane Skeletons from the Sea Hare Aplysia dactylomela (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Marine Natural Products: Parguerol, Deoxyparguerol, and Isoparguerol. New Brominated Diterpenes with Modified Pimarane Skeletons from the Sea Hare Aplysia dactylomelaFrancis Schmitz, Dennis Michaud, and Paul SchmidtCite this: J. Am. Chem. Soc. 1984, 106, 11, 3385Publication Date (Print):May 1, 1984Publication History Published online9 April 2004Published inissue 1 May 1984https://doi.org/10.1021/ja00323a600RIGHTS & PERMISSIONSArticle Views54Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (117 KB) Get e-Alerts Get e-Alerts
Editorial Comment (2016)

No AccessJournal of UrologyAdult Urology1 Aug 2016Editorial Comment Mark W. Ball and Mohamad E. Allaf Mark W. BallMark W. Ball More articles by this author and Mohamad E. AllafMohamad E. Allaf More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2982AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 196(2), p. 333 © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 196Issue 2August 2016Page: 333 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mark W. Ball More articles by this author Mohamad E. Allaf More articles by this author Expand All Advertisement PDF downloadLoading ...
APACHE III OUTCOME PREDICTION AFTER PNEUMONECTOMY (2004)

SOCIETY OF CRITICAL CARE MEDICINE 34TH CRITICAL CARE CONGRESS PHOENIX, ARIZONA, USA JANUARY 15-19, 2005: Poster Presentation: Epidemiology/Outcomes Research (Adult) II
Optical properties of conjugated hydrophobic weak polyelectrolytes: Effects of pH, temperature and ionic strength (2016)

We measure the UV-visible absorption of an annealed hydrophobic conjugated polyelectrolyte as a function of the pH, for different temperatures and ionic strengths. The position of the absorption maximum shifts non-monotonically as the neutralization degree f decreases from 1 to 0, thus defining two regimes. In the hydrophilic regime, 1>f>f1, the red shift is due to dominant direct Coulombic interactions between the charges along the backbone and the ? electrons, without significant conformational effects. In the hydrophobic regime,f1>f>0, the blue shift is dominated by conformational effects with two successive isosbestic points as f decreases. We propose two possible scenarios for the collapse of the chains at low neutralization degrees.
From Expressive Notation to Model-Based Sound Synthesis: a Case Study of the Acoustic Guitar (1999)

The focus of this work is in modeling the unique sound and the playing practices of the acoustic guitar. The results can be applied to other plucked string instruments too. A new extended notation package is used to produce expressive control information. This tool allows the user to add to the input score instrumental expressions and tempo functions. The system includes also a rule formalism that permits further fine tuning of the computer-generated performance. A real-time synthesis engine has been developed based on earlier results in digital waveguide modeling. We also describe an analysis of vibrato in acoustic guitar tones, which provides control information for realistic synthesis.
ACTIVE IMMUNIZATION WITH INFLUENZA VIRUS A AND B IN INFANTS AND CHILDREN (1956)

With the aim of finding a method of influenza virus A and B vaccination with maximal antibody response and minimal untoward reaction, a wide range of dosage and other variations in method were tested among 614 unselected children, of which 110 were studied serologically. Systemic reactions occurred in 22.8 per cent of the children following 1 or more injections and were severe in 9.2 per cent. Reactions were not related to family or individual history of allergy, sex or bodytype structure. Reactions did occur more often and more severely in the very young when the same dosage of vaccine per kg. of body weight was given. Moreover, at different ages systemic reactions were more frequent and more severe when larger doses of vaccine per kg. of body weight were given. No differences in serologic response were found in children who had systemic reactions to the vaccine and those who had none. Serologic response was good even among those children who received the minimum amounts of vaccine per kg. of body weight. The results suggest that primary vaccination is fairly effective with a single small injection of 0.1 ml. vaccine, intradermally, or 0.2 ml. vaccine, subcutaneously. An even higher and more rapid response in antibody titer is probable when 2 small (0.1 ml.) injections of vaccine are given a week apart. There is no higher rise in blood titer of antibody when the primary vaccination is accomplished by a larger dose (0.6 ml. or 0.7 ml.) following a smaller initial dose. A booster dose, whether in a small amount (0.1 ml.) or a larger amount (1.0 ml.) and given 3 to 7 months after the primary vaccination, resulted in a similar favorable rise in titer among the groups which had been given various amounts for primary vaccination. The elevated titer in vaccinated children persisted above the preimmunization levels for 12 to 18 months.
Concomitant Chemoradiotherapy (1990)

The title of Table 4 in the review article "Concomitant Chemoradiotherapy: Rationale and Clinical Experience in Patients With Solid Tumors" by Vokes and Weichselbaum published in the May 1990 issue (J Clin Oncol 8:911–934, 1990) was incorrect. It should have read "Table 4: Selected Randomized Trials in Head and Neck Cancer."
Land Seismic Repeatability Prediction from Near Surface Investigation (2010)

High seismic repeatability is critical to the monitoring program of the Naylor Field because of the small time‐lapse effect related to CO2 injection into a depleted gas reservoir (Naylor). To understand the effect of changing ground conditions on repeatability, we conducted so‐called “micro‐array” investigation of the near‐surface layers at this site. A feature of the injection test site area is the near‐surface karst topography. In such geological terrain, a change in water table level can influence the seismic response and cause changes in the seismic wave scattering pattern. Hence the aim of micro‐array measurements was to determine the properties of the near surface layers during the wet and dry seasons. This could help us understand and ultimately predict the seismic response and hence survey repeatability at a given site. Measurements of seismic response due to near surface property changes (seasonal) could help optimise the design of time lapse surveys which ultimately yields improved survey differencing. Measured elastic properties of the near surface are used to produce seismic response and predict repeatability as a function of the variable soil conditions. Comparison of numerical and field data is finally used to verify the validity of this approach. In this study we investigated the variation of elastic properties of both top soil and the deeper rugose clay‐limestone interface as a function of water depth level. Such tests in fact simulate the measurements conducted in dry and wet seasons and help evaluate the effect of these seasonal variations on the seismic signature, which is then analysed in terms of non‐repeatability. In this study, we use both micro‐borehole (micro VSP) and micro‐refraction arrays to analyse directional properties of the near‐surface. Finally, numerical tests were performed with calibrated soil parameters.
A heuristic method of finding heavy hitter prefix pairs in IP traffic (2009)

This paper describes a heuristic method of finding prefix pairs in IP traffic, which represent more than a prescribed threshold of global traffic. Two Patricia trees are used for finding those source and destination prefixes with a sufficient amount of traffic. A heuristic method is then proposed to identify those pairs of prefixes with a total amount of traffic exceeding a given proportion of global traffic. The proposed algorithm is tested against NetFlow data from Orange's transit IP network.
Phosphinic acid-promoted addition reaction of isocyanides to (Z)-hydroximoyl chlorides: efficient synthesis of α-(hydroxyimino)amides (2015)

The reaction of (Z)-hydroximoyl chlorides with isocyanides promoted by phosphinic acid in the presence of triethylamine proceeds smoothly to afford α-(hydroxyimino)amides in good to high yields. Phosphinic acid plays an important role in effectively promoting the reaction. A wide range of (Z)-hydroximoyl chlorides and isocyanides were found to be suitable for this reaction.
Effect of Annealing on Exciton Diffusion in a High Performance Small Molecule Organic Photovoltaic Material (2017)

Singlet exciton diffusion was studied in the efficient organic photovoltaic electron donor material DTS(FBTTh<sub>2</sub>)<sub>2</sub>. Three complementary time-resolved fluorescence measurements were performed: quenching in planar heterojunctions with an electron acceptor, exciton-exciton annihilation, and fluorescence depolarization. The average exciton diffusivity increases upon annealing from 1.6 × 10<sup>-3</sup> to 3.6 × 10<sup>-3</sup> cm<sup>2</sup> s<sup>-1</sup>, resulting in an enhancement of the mean two-dimensional exciton diffusion length (L<sub>D</sub> = (4Dτ)<sup>1/2</sup>) from 15 to 27 nm. About 30% of the excitons get trapped very quickly in as-cast films. The high exciton diffusion coefficient of the material leads to it being able to harvest excitons efficiently from large donor domains in bulk heterojunctions.
Clinical application of antialdosterone-containing hormone therapy for postmenopausal women. (2007)

Increased awareness of the risk of cardiovascular disease (CVD) in postmenopausal women will aid clinicians in choosing the most appropriate hormone therapy (HT) for their patients. An antialdosterone-containing hormonal therapy offers postmenopausal women advantages beyond simply the relief of menopausal symptoms; drospirenone/estradiol therapy has a theoretical advantage for the modulation of postmenopausal cardiovascular target organ complications. Additionally, drospirenone/ estradiol therapy represents an attractive alternative to other forms of HT.
Role of the frozen elephant trunk procedure for chronic aortic dissection (2017)

The modified frozen elephant trunk repair is particularly well suited for patients with chronic aortic dissection who often require multiple operations to address their extensive disease.
Abstract 13523: The Role of Mitochondrial-Associated-Membranes in Ca-Dependent Arrhythmias (2022)

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced arrhythmic syndrome due to genetic defects of the sarcoplasmic reticulum (SR) Ca release channel complex of ryanodine receptor 2 (RyR2). Recent studies suggest that mitochondria function as a protective Ca buffer to absorb RyR2-mediated aberrant Ca release in CPVT. However, the molecular mechanism underlying the protective Ca buffering function of CPVT mitochondria remains unclear. Hypothesis: We hypothesize that the tethering between SR and mitochondria, also known as mitochondria-associated-membranes (MAMs) are promoted in CPVT to facilitate SR-mitochondria Ca transfer. Moreover, manipulating SR-mitochondria tethering or MAMs impacts arrhythmogenesis in CPVT. Methods: Ventricular myocytes were isolated from a CPVT model of CASQ2 knockout (Cnull) mouse. Cellular immunofluorescence assays and western blots were employed to detect MAMs remodeling in CPVT cells. Pharmacological approach was employed to disrupt MAMs and examine its effect on cellular arrhythmogenesis using live-cell imaging. Results: SR-mitochondria tethering was assessed by examining the interaction between RyR2 and Voltage-dependent anion channel (VDAC), a protein localized in the mitochondrial-outer-membrane. As compared with wild-type (WT), we detected a higher degree of colocalization of immunofluorescence between RyR2 and VDAC in Cnull cells, as well as increased RyR2-VDAC interactions by proximity ligation assay. The expression of SR-mitochondria tethering protein Mitofusin2 was increased in MAMs isolated from CPVT hearts. Colchicine was employed to induce a partial disruption of MAMs in Cnull cells. In intact Cnull cells perfused with β agonist isoproterenol, colchicine exacerbated arrhythmogenic Ca waves. In permeabilized cells, colchicine increased the frequency of arrhythmogenic Ca waves and reduced mitochondrial Ca uptake. Conclusions: Our results support that MAMs are promoted in CPVT cells to facilitate SR-mitochondria Ca transfer so mitochondria can function as a protective Ca buffer. Pharmacological disruption of SR-mitochondria tethering limits SR-mitochondria Ca transfer, thus exacerbating cellular arrhythmic burden.
Alkyne Metathesis with Silica‐Supported and Molecular Catalysts at Parts‐per‐Million Loadings (2016)

Abstract Improvement of the activity, stability, and chemoselectivity of alkyne‐metathesis catalysts is necessary before this promising methodology can become a routine method to construct C≡C triple bonds. Herein, we show that grafting of the known molecular catalyst [MesC≡Mo(O t Bu F6 ) 3 ] ( 1 , Mes=2,4,6‐trimethylphenyl, O t Bu F6 =hexafluoro‐ tert ‐butoxy) onto partially dehydroxylated silica gave a well‐defined silica‐supported active alkyne‐metathesis catalyst [(≡SiO)Mo(≡CMes)(O t Bu F6 ) 2 ] ( 1 /SiO 2‐700 ). Both 1 and 1 /SiO 2‐700 showed very high activity, selectivity, and stability in the self‐metathesis of a variety of carefully purified alkynes, even at parts‐per‐million catalyst loadings. Remarkably, the lower turnover frequencies observed for 1 /SiO 2‐700 by comparison to 1 do not prevent the achievement of high turnover numbers. We attribute the lower reactivity of 1 /SiO 2‐700 to the rigidity of the surface Mo species owing to the strong interaction of the metal site with the silica surface.
VIBRATION MODES OF SPHERICAL SHELLS AND CONTAINMENT VESSELS (2024)

No abstract prepared.
Evolutionary engineered strains of Saccharomyces cerevisiae for efficient lignocellulosic bioethanol production (2014)

Lignocellulosic biomass is an abundant raw material that can be utilized to produce ethanol with the help of Saccharomyces cerevisiae; a promising alternative to today’s energy sources. Conversion of lignocellulosic material (cellulose, hemicellulose and lignin) into fermentable sugars including both hexoses and pentoses results in formation of inhibitory compounds such as acetic acid, furan aldehydes and phenolics that are known to inhibit the yeasts’ metabolic processes. The aims of this study were to i) generate S. cerevisiae strains that can readily convert glucose and xylose into ethanol in the presence of inhibitory compounds, and ii) elucidate the underlying genetic changes of importance for the improved properties of the generated strains. For these purposes, a strain of S. cerevisiae containing genes for xylose reductase, xylitol dehydrogenase and xylulokinase was used. The strain was subjected to mutagenesis followed by evolutionary engineering (repetitive batch and chemostat cultivation), which resulted in populations with improved ethanol yield, improved xylose conversion rate and increased inhibitor tolerance. The complex combination of different genetic alterations in the evolved populations will now be revealed using a DNA/RNA sequencing approach. The acquired knowledge of proteins and pathways important for efficient lignocellulosic bioethanol production will then hopefully allow directed engineering for further improvement of yeast performance.