gebhart/patrepeval huggingface dataset:
Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling (2015)

Hydrogen sulfide (H2S) is an endogenous gaseous biological mediator, which regulates, among others, the oxidative balance of cells under normal physiological conditions, as well as in various diseases. Several previous studies have reported that H2S attenuates inflammatory mediator production. In this study, we investigated the role of H2S in chromatin modulation in an in vitro model of lipopolysaccharide (LPS)-induced inflammation and evaluated its effects on inflammatory cytokine production. Tamm-Horsfall protein 1 (THP-1) differentiated macrophages were pre-treated with sodium hydrosulfide (NaHS) (an H2S donor) at 0.01, 0.1, 0.5 or 1 mM for 30 min. To stimulate cytokine production, the cells were challenged with bacterial LPS (1 µg/ml) for 1, 4, 8 or 24 h. Histone H3 acetylation was analyzed by chromatin immunoprecipitation (ChIP), cytokine production was measured by ELISA and histone deacetylase (HDAC) activity was analyzed using a standard biochemical assay. H2S inhibited the production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in a concentration-dependent manner; it was most effective at the two highest concentrations used. This effect was associated with a decrease in histone H3 acetylation at the IL-6 and TNF-α promoters in the cells exposed to H2S or H2S + LPS. The findings of the present study suggest that H2S suppresses histone acetylation, which, in turn, inhibits chromatin openness, leading to a decrease in the gene transcription of various pro-inflammatory cytokines. Therefore, this mechanism may contribute to the previously demonstrated anti-inflammatory effects of H2S and various H2S donors.
Laboratory evaluation of two schemes for the treatment of coal gasification wastewater: Topical report (1987)

The objective of this study is to evaluate the role of solvent extraction as an additional pretreatment before biological oxidation. A comparison between biological treatment after only dissolved-gas-stripping pretreatment and after dissolved-gas stripping and solvent extraction is presented. Specific tasks include the determination of biological oxidation growth constants and removal efficiencies for primary effluent contaminants. A further objective is to evaluate the effectiveness of using activated carbon as a final polishing step before and after biological oxidation of dissolved-gas-stripped and solvent-extracted pretreated wastewater. Data on the biological oxidation of ammonia-gas-stripped wastewater was developed during a previous study by Drummond et al.
Prévention des déficiences nutritionnelles chez les personnes sans-abri : intérêt d’un aliment de rue enrichi (2006)

National audience
Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy (2021)

Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling, culminating in aortic stenosis, heart failure, and ultimately premature death. Traditional risk factors, such as hypercholesterolaemia and (systolic) hypertension, are shared among atherosclerotic cardiovascular disease and CAVD, yet the molecular and cellular mechanisms differ markedly. Statin-induced low-density lipoprotein cholesterol lowering, a remedy highly effective for secondary prevention of atherosclerotic cardiovascular disease, consistently failed to impact CAVD progression or to improve patient outcomes. However, recently completed phase II trials provide hope that pharmaceutical tactics directed at other targets implicated in CAVD pathogenesis offer an avenue to alter the course of the disease non-invasively. Herein, we delineate key players of CAVD pathobiology, outline mechanisms that entail compromised endothelial barrier function, and promote lipid homing, immune-cell infiltration, and deranged phospho-calcium metabolism that collectively perpetuate a pro-inflammatory/pro-osteogenic milieu in which valvular interstitial cells increasingly adopt myofibro-/osteoblast-like properties, thereby fostering fibro-calcific leaflet remodelling and eventually resulting in left ventricular outflow obstruction. We provide a glimpse into the most promising targets on the horizon, including lipoprotein(a), mineral-binding matrix Gla protein, soluble guanylate cyclase, dipeptidyl peptidase-4 as well as candidates involved in regulating phospho-calcium metabolism and valvular angiotensin II synthesis and ultimately discuss their potential for a future therapy of this insidious disease.
Tunable antennas for mobile devices: Achieving high performance in compelling form factors (2014)

The evolution of modern mobile terminals has been driven by two key factors, the user interface and broadband connectivity. However, while the peak performance near the base station may be state-of-the-art, real world performance (in-building, in suburbs and rural areas, in-car and on-person) has substantially fallen over the years. This has not only impacted achievable data rates and reduced battery life but, in many cases, actually prevented useful connections for voice or data. The key factor driving this degradation has been changing antenna location and reduced antenna volume driven by the race for thinner and display-dominated platforms. Reduced antenna volume leads to a tradeoff between bandwidth and efficiency. To maintain acceptable efficiency, tunable and reconfigurable antennas are being deployed to enable effective use of reduced instantaneous bandwidths. This capability brings new challenges as well as new opportunities to the handset designer.
On the plasma parameters of a planar inductive oxygen discharge (2000)

Langmuir probes and a quadrupole mass spectrometer were used to determine the plasma parameters of an oxygen plasma in a planar inductive discharge. The electron density, effective electron temperature, the dc plasma potential and the electron energy probability function (EEPF) in the discharge centre plane were investigated as functions of power, gas pressure and radial position. The ion energy distribution and relative density of positive ions at the radial sheath edge were investigated as functions of power and pressure. A volume-averaged global model of the electronegative oxygen discharge is developed. The model uses a power balance equation to account for energy deposited into the plasma and lost via collisions and particle flux. The particle densities are modelled via rate equations estimated from collision cross sections assuming Maxwellian electron energy distribution functions. The volume-averaged model is shown to predict the experimental trends over a range of process conditions.
Modelling and Control Design for a High Power Resonant DC-DC Converter (2012)

This paper involves the development of a dynamic model for a resonant dc-dc converter topology recently proposed at the University of Toronto. The model makes use of the conservation of energy principle. This dynamic model employs an averaging technique, since converter switching is neglected. A simple test network for validation of the proposed model is developed. Based on the validated model, a concept for closed loop control of the system, including the selection of which variables are optimal to control, is determined.
UGA suppression by normal tRNATrPin Escherichia coli: codon context effects (1981)

The nucleotide sequences at the 3' side of in-phase UGA termination codons in mRNAs of various prokaryotic genes were re-examined. An adenine (A) residue is found to be adjacent to the 3' side of UGA in mRNAs which code for readthrough proteins by the suppression of UGA by normal Escherichia coli tRNA Trp. It is suggested that the nature of the nucleotide following a UGA codon determines whether the UGA signals inefficiently or efficiently the termination of polypeptide chain synthesis: an A residue at this position permits the UGA readthrough process.
Serial interference cancellation method for CDMA (1994)

A serial interference canceller for CDMA is proposed, where progressive stages in the canceller strip away the noise. For 31 chip Gold codes, 17 users, and imperfect power control, the proposed canceller can obtain an average BER of 4 × 10-6 compared with 3 × 10-3 for a parallel canceller after four stage cancellations. The delay penalty is 21 bit periods.
Characteristics of Foreign-Born Persons in the Swiss Hepatitis C Cohort Study: Implications for Screening Recommendations (2016)

The identification of subgroups in which HCV infection is particularly frequent might allow for better targeting HCV screening among foreign-born persons in Switzerland and elsewhere.
Feature Subset Selection for Improving the Performance of False Positive Reduction in Lung Nodule CAD (2005)

In this paper, we propose a feature subset selection method based on genetic algorithms to improve the performance of false positive reduction in lung nodule CAD. It is coupled with a classifier based on support vector machines. The proposed approach determines automatically the optimal size of the feature set and chooses the most relevant features from a feature pool. Its performance was tested using a lung nodule database (66 true nodules and 123 false ones) acquired by multi-slice CT scans. From 23 features calculated for each detected structure, the suggested method determined 9 as the optimal feature subset size and selected the nine features. A support vector machine-based classifier trained with the optimal feature subset has resulted in 92.4% sensitivity and 85.4% specificity using leave-one-out cross validation. Experiments also showed significant improvement achieved by a system incorporating the proposed method over a system without it. It can be also applied to other machine learning problems: e.g. computer-aided diagnosis of lung nodules.
Supported metallocene catalysts prepared by impregnation of MAO modified silica by a metallocene/monomer solution (1998)

Silica supported (butylcyclopentadienyl)2ZrCl2/MAO catalysts were synthesized according to the “incipient wetness” method from a solution of metallocene in a liquid monomer. The monomer was allowed to polymerize yielding a catalyst containing polyhexene (PH), polystyrene (PS) or polyoctadiene (PO). One catalyst containing no polymer was also synthesized. The catalysts were used to polymerize ethene at 70°C and 4 bar total pressure. The measured average activities were 5 300 kg PE/(mol Zr · h) for (BuCp)2ZrCl2/MAO/PH/SiO2, 8 600 kg PE/(mol Zr · h) for (BuCp)2ZrCl2/MAO/PS/SiO2, 3 400 kg PE/(mol Zr · h) for (BuCp)2ZrCl2/MAO/PO/SiO2 and 5 700 kg PE/(mol Zr · h) for (BuCp)2ZrCl2/MAO/SiO2. The polyhexene, polystyrene or polyoctadiene in the catalyst forms a protective layer around the active sites. Even after exposure to air for five hours these catalysts retain some polymerization activity.
Anisotropic three-dimensional peptide channels guide neurite outgrowth within a biodegradable hydrogel matrix (2006)

The objective of this study was to investigate the neurite guidance potential of concentration gradients of glycine-arginine-glycine-aspartic acid-serine (GRGDS) oligopeptides immobilized within three-dimensional patterned cylindrical volumes created in a biodegradable nerve guidance matrix. This was achieved using ultraviolet (UV) laser micropatterning of a hyaluronan (HA) hydrogel matrix modified with S-2-nitrobenzyl cysteine. Upon exposure to focused laser light, the 2-nitrobenzyl group was cleaved, exposing thiol groups which reacted with maleimide-terminated GRGDS exclusively within these laser-defined volumes. We show that the UV laser micropatterning technique can be used to create GRGDS peptide concentration gradients within the oligopeptide channels and that these channels guide neurite outgrowth from primary neural cells.
Injectivity, projectivity, and the axiom of choice (1979)

We study the connection between the axiom of choice and the principles of existence of enough projective and injective abelian groups. We also introduce a weak choice principle that says, roughly, that the axiom of choice is violated in only a set of different ways. This principle holds in all ordinary Fraenkel-Mostowski-Specker and Cohen models where choice fails, and it implies, among other things, that there are enough injective abelian groups. However, we construct an inner model of an Easton extension with no nontrivial injective abelian groups. In the presence of our weak choice principle, the existence of enough projective sets is as strong as the full axiom of choice, and the existence of enough free projective abelian groups is nearly as strong. We also prove that the axiom of choice is equivalent to “all free abelian groups are projective” and to “all divisible abelian groups are injective."
Federated Spatial Cursors (2007)

Abstract. The usage of small mobile devices for data-intensive applications becomes more and more self-evident. As a consequence we have to consider these devices and their inherent characteristics in future system designs, like the limitations of memory and communication bandwidth. For example, when querying data servers for information, a mobile application can hardly anticipate the size of the result set. Our approach is to give more control over the data delivery process to the application, so that it can be adapted regarding its device status, the costs and availability of communication channels, and the user’s needs. This paper introduces a flexible and scalable approach by providing spatially federated cursor functionality. It is based on an open federation over a set of loosely coupled data sources that provide simple object retrieval interfaces. 1.
Adaptive Flight Control in the Presence of Limits on Magnitude and Rate (2019)

Input constraints as well as parametric uncertainties must be accounted for in the design of safe control systems. This paper presents an adaptive controller for multiple-input-multiple-output (MIMO) plants with input magnitude and rate saturation in the presence of parametric uncertainties. A filter is introduced in the control path to accommodate the presence of rate limits. An output feedback adaptive controller is designed to stabilize the closed loop system even in the presence of this filter. The overall control architecture includes adaptive laws that are modified to account for the magnitude and rate limits. Analytical guarantees of bounded solutions and satisfactory tracking are provided. Three flight control simulations with nonlinear models of the aircraft dynamics are provided to demonstrate the efficacy of the proposed adaptive controller for open loop stable and unstable systems in the presence of uncertainties in the dynamics as well as input magnitude and rate saturation.
ChemInform Abstract: RINGSCHLUSSRK. AN ENCARBAMOYL‐AZIDEN, SYNTH. VON TETRAHYDRO‐3‐INDAZOLINONEN UND 4‐IMIDAZOLIN‐2‐ONEN (1972)

Abstract Aus den Iminen (I) erhält man mit Phosgen die Carbaminsäurechloride (II), die mit Natriumazid zu (III) austauschen.
Consistent and robust 4D whole-brain segmentation: Application to traumatic brain injury (2014)

We propose a consistent approach to automatically segmenting longitudinal magnetic resonance scans of pathological brains. Using symmetric intra-subject registration, we align corresponding scans. In an expectation-maximization framework we exploit the availability of probabilistic segmentation estimates to perform a symmetric intensity normalisation. We introduce a novel technique to perform symmetric differential bias correction for images in presence of pathologies. To achieve a consistent multi-time-point segmentation, we propose a patch-based coupling term using a spatially and temporally varying Markov random field. We demonstrate the superior consistency of our method by segmenting repeat scans into 134 regions. Furthermore, the approach has been applied to segment baseline and six month follow-up scans from 56 patients who have sustained traumatic brain injury (TBI). We find significant correlations between regional atrophy rates and clinical outcome: Patients with poor outcome showed a much higher thalamic atrophy rate (4.9 ± 3.4%) than patients with favourable outcome (0.6 ± 1.9%).
Plan-based complex event detection across distributed sources (2008)

Complex Event Detection (CED) is emerging as a key capability for many monitoring applications such as intrusion detection, sensor-based activity &amp; phenomena tracking, and network monitoring. Existing CED solutions commonly assume centralized availability and processing of all relevant events, and thus incur significant overhead in distributed settings. In this paper, we present and evaluate communication efficient techniques that can efficiently perform CED across distributed event sources. Our techniques are plan-based: we generate multi-step event acquisition and processing plans that leverage temporal relationships among events and event occurrence statistics to minimize event transmission costs, while meeting application-specific latency expectations. We present an optimal but exponential-time dynamic programming algorithm and two polynomial-time heuristic algorithms, as well as their extensions for detecting multiple complex events with common sub-expressions. We characterize the behavior and performance of our solutions via extensive experimentation on synthetic and real-world data sets using our prototype implementation.
Synthesis and Biological Screening of New 2-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-4-aryl Thiazole Derivatives as Potential Antimicrobial Agents (2023)

A new series of 2-(5-aryl-1-phenyl-1<i>H</i>-pyrazol-3-yl)-4-aryl thiazoles (<b>10a</b>-<b>ab</b>) have been synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1<i>H</i>-pyrazole-3-carbothioamide (<b>7a</b>-<b>d</b>) with substituted phenacyl bromide (<b>8a</b>-<b>f</b>). The structure of newly synthesized 2-(5-aryl-1-phenyl-1<i>H</i>-pyrazol-3-yl)-4-aryl thiazole (<b>10a</b>-<b>ab</b>) derivatives was characterized by spectroscopic analysis. The compounds <b>10a</b>-<b>ab</b> were evaluated for <i>in vitro</i> antibacterial activity against <i>Escherichia coli</i> (NCIM 2574), <i>Proteus mirabilis</i> (NCIM 2388), <i>Bacillus subtilis</i> (NCIM 2063), <i>Staphylococcus aureus</i> (NCIM 2178), and <i>in vitro</i> antifungal activity against <i>Aspergillus niger</i> (ATCC 504) and <i>Candida albicans</i> (NCIM 3100). Among the twenty-eight pyrazolyl<b>-</b>thiazole derivatives, six compounds, <b>10g</b>, <b>10h</b>, <b>10i</b>, <b>10j</b>, <b>10o</b>, and <b>10t</b>, showed good activity against <i>P. mirabilis</i>; four compounds <b>10q</b>, <b>10u</b>, <b>10y</b>, and <b>10z</b> showed good activity against <i>S. aureus</i>; and twenty-four derivatives showed good antifungal activity against <i>A. niger</i>. Compounds <b>10g</b>, <b>10q</b>, <b>10r</b>, <b>10s</b>, and <b>10ab</b> showed comparable activity with respect to the reference drug Ravuconazole. Thus, the significant antimicrobial activity of 2-(5-aryl-1-phenyl-1<i>H</i>-pyrazol-3-yl)-4-aryl thiazole (<b>10a</b>-<b>ab</b>) derivatives prompted that these scaffolds could assist in the development of lead compounds to treat microbial infections.
Physical Characteristics and the Format of Digital Versatile Disc-Recordable (2001)

The 4.7 GB digital versatile disc-recordable (DVD-R) disc format has been developed to introduce very useful recordable feature in the digital versatile disc (DVD) family. We developed disc media and the write pulse control method. In our examination, recorded signal qualities of the DVD-R disc are equivalent to those of the DVD-Read-Only disc (ROM). We realized a jitter value of less than 6% using write pulse strategy with the adaptive edge shift control technology. The physical characteristics of the recorded signals satisfy all the requirements of single-layered DVD-ROM disc.
Visualization and Animation of State Estimation Performance (2005)

Reliable real time system "visibility" depends on a reliable and accurate state estimator. Present experience with state estimators indicates that its reliability is below expectations (an average of 5% non-convergent cases). The causes of this poor performance have been identified in earlier work by the authors and alternative robust state estimators have been proposed. For any state estimator, it is important to develop techniques for monitoring the performance of the state estimator and identification of potential problems such as bad sensors, consistent errors, modeling errors, etc. The paper presents visualization and animation methods that assist this process. It is demonstrated that bad data many times can be detected via visualization methods. The methodologies are demonstrated with a hybrid three-phase state estimator which addresses the issue of systematic errors from modeling and imbalance errors. This estimator is enhanced by visualization and animation methods that provide valuable information to users and system operators "at a glance". The procedure and the visualization techniques are demonstrated on TVA's 500 kV transmission system.
Identification of Equine Cecal Bacteria Producing Amines in an In Vitro Model of Carbohydrate Overload (2003)

Acute laminitis has been associated with the overgrowth of gram-positive bacteria within the equine hindgut, causing the release of factor(s) leading to ischemia-reperfusion of the digits. The products of fermentation which trigger acute laminitis are, as yet, unknown; however, vasoactive amines are possible candidates. The objectives of this study were to use an in vitro model of carbohydrate overload to study the change in populations of cecal streptococci and lactobacilli and to establish whether certain species of these bacteria were capable of producing vasoactive amines from amino acids. Cecal contents from 10 horses were divided into aliquots and incubated anaerobically with either corn starch or inulin (fructan; both at 1 g/100 ml). Samples were taken at 6-h intervals over a 24-h period for enumeration of streptococci, lactobacilli, and gram-negative anaerobes by a dilution method onto standard selective growth media. The effects of the antibiotic virginiamycin (1 mg/100 ml) and calcium hydrogen phosphate (CaHPO(4); 0.3 g/100 ml) were also examined. Fermentation of excess carbohydrate was associated with increases in numbers of streptococci and lactobacilli (2- to 3.5-log unit increases; inhibited by virginiamycin) but numbers of gram-negative anaerobes were not significantly affected. A screening agar technique followed by 16S rRNA gene sequence analysis enabled the identification of 26 different bacterial strains capable of producing one or more vasoactive amines. These included members of the species Streptococcus bovis and five different Lactobacillus spp. These data suggest that certain bacteria, whose overgrowth is associated with carbohydrate fermentation, are capable of producing vasoactive amines which may play a role in the pathogenesis of acute laminitis.
Self-Supervised Transformers for fMRI representation (2021)

We present TFF, which is a Transformer framework for the analysis of functional Magnetic Resonance Imaging (fMRI) data. TFF employs a two-phase training approach. First, self-supervised training is applied to a collection of fMRI scans, where the model is trained to reconstruct 3D volume data. Second, the pre-trained model is fine-tuned on specific tasks, utilizing ground truth labels. Our results show state-of-the-art performance on a variety of fMRI tasks, including age and gender prediction, as well as schizophrenia recognition. Our code for the training, network architecture, and results is attached as supplementary material.