gebhart/patrepeval huggingface dataset:
Use of Single-Operator Pancreatoscopy (SpyGlass™) in the Evaluation of Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasms (2013)

Purpose: Main pancreatic duct intraductal papillary mucinous neoplasms (MD-IPMN) carry a significant risk for developing pancreatic adenocarcinoma. Surgical resection is the only curative option in these patients. Not all patients are operative candidates. Obtaining additional data to elucidate who might be at increased risk for developing cancer is desirable. Data on the utility of single-operator pancreatoscopy (SpyGlass™, Boston Scientific, Natick, MA, USA) for the evaluation of MD-IPMN are scarce. We aim to report our experience. Methods: A retrospective descriptive analysis was performed on all patients with MD-IPMN that underwent SpyGlass pancreatoscopy at a tertiary care center from July, 2009 to May, 2013. Results: A total of 13 patients were identified. Seven were males; mean age 71 years (range: 57-84). Indications for the procedure included findings suspicious for MD-IPMN on endoscopic ultrasound (EUS), multi-detector computed tomography (MDCT) and magnetic resonance pancreatography (MRCP). The ampulla was normal in four and patulous in nine. In three with patulous pancreatic os, no mucin was noted. SpyGlass findings included a mass or lesion with frond-like papillary projections and mucin in nine, mass or lesion and mucin but no frond-like papillary projections in four. Ten lesions were identified in the head of pancreas (HOP), one in both HOP and body, and two in the body alone. In two patients with suspected HOP IPMN by imaging, the lesion was in the body (neck) in one and mixed HOP and body in another (extending beyond the pre-Spyglass determination). Pathologic diagnosis of MD-IPMN was confirmed in 9 patients. Five of these nine were confirmed by pancreatoscopy-guided biopsy (SpyBite™, Boston Scientific, Natick, MA, USA): revealing adenocarcinoma in 2, high-grade dysplasia (HGD) in one, moderate-grade dysplasia (MGD) in 1, and low-grade dysplasia (LGD) in one. Another three were confirmed by Whipple's procedure, revealing LGD in one and HGD in two patients. In one patient MD-IPMN was confirmed by EUS guided FNA that revealed adenocarcinoma (lesion in the body). One patient was noted to have a fistula into the stomach. The pancreatic duct in this patient was accessed through the stomach and the ampulla. SpyGlass was successful in all patients. No complications were reported. Confirmation of malignancy in five patients during SpyGlass convinced four patients to undergo surgery. The fifth patient (with a gastric fistula) did not want further intervention. Conclusion: Single-operator pancreatoscopy is a viable method to confirm the diagnosis and establish malignant transformation when evaluating patients with suspected MD-IPMNs by imaging. Studies to assess the incremental yield of SpyGlass pancreatoscopy in these patients are needed. Disclosure - Dr. Raijman-Boston Scientific Speaker.
Rôle fonctionnel du CD23 dans la production de monoxyde d'azote par les monocytes humains. (1995)

L'activation de CD23 (FceRII) a la surface de monocytes/macrophages humains declenchee par la liaison de certains anticorps monoclonaux specifiques, ou d'IgE sous forme complexee multivalente conduit, finalement, a la production de mediateurs pro-inflammatoires. La stimulation du metabolisme de la L-arginine entraine la formation de L-citrulline et de NO ; ce dernier active une guanylyl cyclase soluble (GCs) qui induit la production de GMPc puis, indirectement, celle d'AMPc. Ces phenomenes sont inhibes par des analogues competitifs de la L-arginine. L'engagement de la molecule CD23 a la surface des monocytes stimule une nitric oxide synthase de type inductible (NOSi), conduisant a la production de TNFα qui agit alors comme facteur autocrine d'amplification. Cette voie, exacerbee dans certaines maladies inflammatoires, semble jouer un role important dans la differenciation des cellules du lignage monocytaire, leur capacite de produire des mediateurs pro-inflammatoires et sur leurs fonctions cytotoxiques, notamment vis-a-vis de micro-organismes a replication intracellulaire.
Frequency stabilization of a single mode terahertz quantum cascade laser to the kilohertz level (2009)

A simple analog locking circuit was shown to stabilize the beat signal between a 2.408 THz quantum cascade laser and a CH(2)DOH THz CO(2) optically pumped molecular laser to 3-4 kHz (FWHM). This is approximately a tenth of the observed long-term (t approximately sec) linewidth of the optically pumped laser showing that the feedback loop corrects for much of the mechanical and acoustic-induced frequency jitter of the gas laser. The achieved stability should be sufficient to enable the use of THz quantum cascade lasers as transmitters in short-range coherent transceivers.
Experimental and Theoretical Studies on Arene‐Bridged Metal–Metal‐Bonded Dimolybdenum Complexes (2014)

The bis(hydride) dimolybdenum complex, [Mo2(H)2{HC(N-2,6-iPr2C6H3)2}2(thf)2], 2, which possesses a quadruply bonded Mo2(II) core, undergoes light-induced (365 nm) reductive elimination of H2 and arene coordination in benzene and toluene solutions, with formation of the Mo(I)2 complexes [Mo2{HC(N-2,6-iPr2C6H3)2}2(arene)], 3⋅C6H6 and 3⋅C6H5Me, respectively. The analogous C6H5OMe, p-C6H4Me2, C6H5F, and p-C6H4F2 derivatives have also been prepared by thermal or photochemical methods, which nevertheless employ different Mo2 complex precursors. X-ray crystallography and solution NMR studies demonstrate that the molecule of the arene bridges the molybdenum atoms of the Mo(I)2 core, coordinating to each in an η(2) fashion. In solution, the arene rotates fast on the NMR timescale around the Mo2-arene axis. For the substituted aromatic hydrocarbons, the NMR data are consistent with the existence of a major rotamer in which the metal atoms are coordinated to the more electron-rich C-C bonds.
Alcoholism and Rapid Progression to AIDS After Seroconversion (1994)

Rapid progression of infection with human immunodeficiency virus type 1 (HIV-1) to AIDS after seroconversion is rare; it has been associated with coinfection by cytomegalovirus or human T lymphotrophic virus type I. We describe an alcoholic patient whose condition progressed to AIDS 3 months after HIV-1 seroconversion occurred. Culture of peripheral blood mononuclear cells yielded a syncytium-inducing variant of HIV-1. T lymphocytes showed no spontaneous cytotoxic activity against HIV-infected cells, nor could such activity be demonstrated following stimulation with HIV-1 antigen in the presence of recombinant interleukin-2. We hypothesize that our patient's accelerated course was due to alcohol abuse, which may have suppressed T cell function and stimulated HIV replication.
Pollination of Crown Vetch (1958)

CROWN VETCH Corenilla varia L., Penngift variety, is a plant that recently has been given a considerable publicity as a ground cover crop for highway and railroad banks with possibilities for other uses. This plant grows as a heavy mat of stems about two and one-half feet high. It has been known to survive in one location for more than 50 years. Because of this longevity and the heavy mat of stems and roots, the plant has proven to be quite valuable for the prevention of erosion and for soil improvement.
Experimental Results from Iddf Testing (1996)

In this paper, we present experimental results from a test method, called Iddf testing, baesd on the multiple sampling and processing of the consumption current, Idd. This method can be seen as an extension of Iddq testing since the Idd frequency spectrum, instead of DC levels, is used to detect defects or faults. The results show that our method is less sensitive to noise than Iddq testing Keywords: test, integrated circuits, Fast Fourier Transform, consumption current, experimental results, bridging faults, noise, Iddq testing
Low radiation dose C-arm cone-beam CT based on prior image constrained compressed sensing (PICCS): including compensation for image volume mismatch between multiple data acquisitions (2009)

C-arm based cone-beam CT (CBCT) has evolved into a routine clinical imaging modality to provide threedimensional tomographic image guidance before, during, and after an interventional procedure. It is often used to update the clinician to the state of the patient anatomy and interventional tool placement. Due to the repeatedly use of CBCT, the accumulated radiation dose in an interventional procedure has become a concern. There is a strong desire from both patients and health care providers to reduce the radiation exposure required for these exams. The overall objective of this work is to propose and validate a method to significantly reduce the total radiation dose used during a CBCT image guided intervention. The basic concept is that the first cone-beam CT scan acquired at the full dose will be used to constrain the reconstruction of the later CBCT scans acquired at a much lower radiation dose. A recently developed new image reconstruction algorithm, Prior Image Constrained Compressed Sensing (PICCS), was used to reconstruct subsequent CBCT images with lower dose. This application differs from other applications of the PICCS algorithm, such as time-resolved CT or fourdimensional CBCT (4DCBCT), because the patient position may be frequently changed from one CBCT scan to another during the procedure. Thus, an image registration step to account for the change in patient position is indispensable for use of the PICCS image reconstruction algorithm. In this paper, the image registration step is combined with the PICCS algorithm to enable radiation dose reduction in CBCT image guided interventions. Experimental results acquired from a clinical C-arm system using a human cadaver were used to validate the PICCS algorithm based radiation dose reduction scheme. Using the proposed method in this paper, it has been demonstrated that, instead of 300 view angles, this technique requires about 20 cone-beam view angles to reconstruct CBCT angiograms. This signals a radiation dose reduction by a factor of approximately fifteen for subsequent acquisitions.
Redox‐Sensitive Stomatocyte Nanomotors: Destruction and Drug Release in the Presence of Glutathione (2017)

The development of artificial nanomotor systems that are stimuli-responsive is still posing many challenges. Herein, we demonstrate the self-assembly of a redox-responsive stomatocyte nanomotor system, which can be used for triggered drug release under biological reducing conditions. The redox sensitivity was introduced by incorporating a disulfide bridge between the hydrophilic poly(ethylene glycol) block and the hydrophobic polystyrene block. When incubated with the endogenous reducing agent glutathione at a concentration comparable to that within cells, the external PEG shells of these stimuli-responsive nanomotors are cleaved. The specific bowl-shaped stomatocytes aggregate after the treatment with glutathione, leading to the loss of motion and triggered drug release. These novel redox-responsive nanomotors can not only be used for remote transport but also for drug delivery, which is promising for future biomedical applications.
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies (2011)

Apocrine carcinoma of the breast has recently been refined through gene expression profiling. Due to various pathological studies, we compared the results with the MDA-MB-453 breast cancer cell line, a proposed model for apocrine breast carcinoma. The MDA-MB-453 cell line is androgen receptor-positive and `triple-negative' in respect to estrogen receptor-α, progesterone receptor and the Her-2/neu protein expression. Cytogenetic analysis of the cell line revealed a hypertriploid clone characterized by extensive numerical and structural abnormalities including loss of the 9p.21 locus (P16-INK4a gene), also evidenced by the lack of p16(INK4A) protein expression in Western blot analysis and immunocytochemistry assays. Gains of chromosomes 7 and 17 without underlying EGFR, HER-2/neu, and TOP2A gene amplification were also observed. A mutation in the K-RAS gene (Gly13Asp GGC>GAC) was identified in the cell line, which was not observed in the six patient samples of apocrine breast carcinomas examined. Similarly, constitutive activation of the MAPK/ERK signaling pathway and deregulation of cell cycle proteins (p16-/pRb-/cyclin D1+ phenotype) with exceedingly high proliferation observed in the MDA-MB-453 cell line were not found in the tissue samples. In conclusion, the MDA-MB-453 cell line shares certain features with apocrine breast carcinoma but differs from patient tissues with regard to various significant characteristics, limiting the value of this cell line as a model for human apocrine breast carcinoma investigations. In contrast to the cell line, EGFR-positive apocrine carcinomas do not harbor K-RAS gene mutations, rendering these tumors amenable to targeted therapy with EGFR inhibitors.
Manipulation of freestanding Au nanogears using an atomic force microscope (2007)

We have fabricated freestanding nanogears by selectively etching single crystalline Au nanoplates and assembled them tooth to tooth using an atomic force microscope (AFM). The nanogears, with one center hole surrounded by six teeth, are smaller than 500 nm in overall size and 60–70 nm in thickness. We demonstrate that blunt AFM tips on stiff cantilevers are effective for the nondestructive manipulation of ductile and flat nano-objects having large contact areas with the substrate, and we discuss the results on the basis of nanomechanical aspects. We expect that the precise AFM manipulation combined with the etch-based fabrication techniques for the freestanding nanocomponents will be useful in the development and post-repair of sophisticated nanoelectromechanical systems.
Parity-Time Acoustic Metamaterials and Unidirectional Invisible Sensors (2014)

We theoretically and experimentally investigate the unique scattering properties of parity-time acoustic systems. We observe acoustic invisibility of airborne sound at audible frequencies in a parity-time symmetric meta-molecule made of perfectly balanced gain and loss subunits. This is achieved in a waveguide configuration using electro-acoustic resonators loaded with non-Foster elements, which are tailored to induce invisibility at the design frequency. This unidirectional reflectionless system is fully stable and self-sensing, allowing for robust implementation of parity-time acoustic metamaterials for loss compensation, non-invasive sensing and advanced acoustic signal manipulation.
A simple wafer-level measurement technique for predicting oxide reliability (1995)

A new wafer-level measurement technique, the differential gate antenna analysis, has been developed to detect weaknesses in sub-micrometer oxide. This simple technique involves the use of dual antenna structures with different gate oxide areas but the same antenna area ratio. The critical parameter is the difference in their failure levels. It is shown that such a differential measurement of antenna failures correlates with product failure during accelerated life testing. The differential antenna structures are thus proven useful for real-time wafer-level monitoring of oxide reliability.
High Quality Laser Processing Technology with Deep Ultraviolet Picosecond Laser (2017)

We are summarizing the development states of CLBO nonlinear crystal, picosecond laser light source, and laser processing system for the development of high quality laser processing using 266 nm picosecond laser. In addition, we will introduce the development direction of the NEDO project. With the development of high quality, long life CLBO crystal and the development of picosecond laser using gain switched semiconductor laser as seed laser, it became possible to develop a practical high power 266 nm picosecond laser. In the NEDO project, we are aiming to develop a high quality laser processing system that can be introduced into actual production. Toward this goal, we will develop a high power 266 nm picosecond laser with an average output of 50 W combined with high speed and high precision beam delivery system.
Management of Acetolactate Synthase (ALS)–Resistant Common Cocklebur (Xanthium strumarium) in Soybean (2004)

A fixed-plot management study for control of acetolactate synthase (ALS)–resistant common cocklebur in soybean was initiated in 1994 at Fayetteville, AR. Three susceptible and three imazaquin-resistant common cocklebur plants were transplanted into the field, and seed (burs) were distributed throughout the plots in the fall of 1994. Herbicide treatments included imazaquin, chlorimuron, and chlorimuron plus metribuzin applied each year from 1995 through 1999 and herbicide rotations containing ALS inhibitors and herbicides with alternative modes of action. Effectiveness of management systems and the dynamics of the development of common cocklebur resistance, including development of resistance to imazaquin and chlorimuron, were evaluated. Imazaquin controlled susceptible common cocklebur populations in 1995 but not the resistant population, resulting in significant soybean yield reduction. By the end of the 1996 season, the resistant biotype dominated imazaquin plots, and a high level of cross-resistance to chlorimuron was observed in the population. Resistant populations were reduced by non-ALS herbicide programs of sulfentrazone plus clomazone applied preemergence (PRE), metribuzin plus clomazone applied PRE followed by bentazon applied postemergence (POST), and transgenic herbicide programs of glyphosate and glufosinate applied POST. Rotating ALS inhibitors with non–ALS-inhibiting heribicides may slow the development of resistance, but resistant individuals may eventually dominate the population.
Information et pouvoir: Essai sur le sens de l'information et son enjeu politiqueBlaise Lempen Lauzanne: L'âge d'homme, 1980, 167 p. (1981)

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TNF-MEDIATED REACTIVATION OF LATENT MURINE CYTOMEGALOVIRUS (MCMV) IN VIVO OCCURS IN THE ABSENCE OF IMMUNOSUPPRESSION (1998)

76 Despite the advent of effective antiviral agents, cytomegalovirus (CMV) reactivation from latency results in significant morbidity and mortality in immunosuppressed patients. Immunosuppression has previously been associated with CMV infection in a variety of clinical scenarios and experimental protocols. The role of immunosuppression in viral reactivation has not been clearly defined. CMV exists as intranuclear genome in the absence of detectable viral transcripts. IE genes represent the first set of viral genes transcribed in productively infected cells. Using a murine model of CMV, we have recently characterized latent MCMV infection and have demonstrated latent infection in endothelial cells in the heart, spleen, and liver and macrophages in the lung. Immediate Early (IE) RNA was not detectable by RT-PCR. Thus, latent MCMV appears to be transcriptionally inactive.1 The trigger for gene transcription remains unknown. We hypothesize that induction of IE transcripts is likely to be a crucial event in reactivation of latent virus. We are presently investigating the role of TNF as a possible mediator of CMV reactivation in vivo by injecting recombinant TNF-α into latently infected mice. We have focused on TNF because clinical observations indicate that elevated levels of TNF are associated with reactivation of the virus in the context of antibody induction therapy and allograft rejection in immunosuppressed patients, and sepsis in non-immunosuppressed patients. We have shown, for the first time, that TNF induces expression of MCMV IE RNA in the lungs of latently infected mice in the absence of immunosuppression. Studies are in progress to determine whether genes associated with later stages of the viral life cycle are induced by TNF and whether infectious virus is produced. These data suggest that TNF may play an important role in the reactivation of latent CMV, in the absence of immunosuppression, and provide a provocative insight into the mechanisms of CMV reactivation.
Picolinyl esters as derivatives for the structural determination of long chain branched and unsaturated fatty acids (1982)

3-Picolinyl esters were prepared from n-, iso-, anteiso- and unsaturated long chain fatty acids and were examined by gas chromatography and mass spectrometry. The spectra contained ions which were diagnostic of the position of both the methyl branching and the double bond, and could be rationalized by assuming hydrogen abstraction from the chain by the nitrogen of the pyridine ring and cleavage at the resulting radical site. The derivatives were easy to prepare and gave more informative spectra than the previously used pyrrolidides.
Using XML for representation and visualization of elaborated VHDL-AMS models (2002)

The paper presents a newly developed XML intermediate for fully elaborated VHDL-AMS designs. The intermediate contains both complete static-semantic information inherent to VHDL-AMS and dynamic, simulation-related information, such as the current values of signal drivers or the dynamic equation sets. Therefore the intermediate can be used for the development of VHDL-AMS related applications. The presented XML intermediate was successfully used for HTML export of design structures.
OBSERVATIONS ON “PATHOLOGIC” FETAL BRADYCARDIA (1959)

Abstract Since 1893 when Von Winckel 1 drew attention to the association of fetal bradycardia with poor fetal outcome, slowing of the fetal heart rate to less than 100 beats per minute between contractions has been considered the chief criterion of fetal distress. 2 Application of this dictum to clinical obstetrics has produced a number of seeming inconsistencies, for bradycardia of this magnitude has been frequently noted both in the antepartum period and during labor, yet the infant has been in good condition at birth. In preliminary reports of the electronic evaluation of the fetal heart rate by continuous recording, 3, 4 an attempt was made to differentiate physiologic and pathologic bradycardia by their respective V and U shaped patterns. The pathologic fetal bradycardia which was discussed in detail in these earlier studies was shown to be due to umbilical cord compression. 4 In this report a different type of pathologic fetal bradycardia will be described which is thought to be due primarily to acute fetal hypoxia. A hypothesis will be advanced which may explain the underlying mechanism. However, the need to measure continuously and quantitatively the many factors which may influence the fetal heart rate precludes definite conclusions at this time.
Mixer—Loader—Applicator Exposure and Percutaneous Absorption Studies Involving EPTC Herbicide (1988)

The skin penetration potential of EPTC was evaluated by the topical application of [propyl-1-14C]-EPTC (specific activity, 1.67 mCi/mmole) in water to the clipped back skin (22.9 ug/cm2, 25 cm2 and 21.5 ug/cm2, 2.54 cm2) of adult male Sprague-Dawley rats. All glass metabolism cages were used to collect respiratory 14CO2 while special skin mounted XAD-2 resin traps were used to collect 14C-volatiles. Approximately 14.7% of the applied dose was absorbed and/or excreted during 24 hours post administration. The remaining dose evaporated (77.8%) or remained on the surface of the skin (1.3—2.8%). Less than 1% was recovered as respired 14CO2. In a separate field study, a mixer/loader/applicator was monitored while applying a PPG brand of EPTC, GENEP 7EC. Air samples, cloth patches, hand rinses, and urine samples were obtained and analyzed for EPTC or metabolites. Total absorbed dose was determined to be 5.6 mg/day (0.074 mg/kg of b.w.) for a 75 kg man applying EPTC to 120 acres of soil/day. On the basis of a percutaneous absorption rate in the rat of 14.7%/24 hours, a worker exposure of 0.074 mg/kg/day of b.w., and a NOEL of 5.0 mg/kg/day from animal toxicity studies, margins of safety of 68 to 340 were determined for workers applying EPTC herbicide.