gebhart/patrepeval huggingface dataset:
[Dermatologic therapy unit anti-androgens]. (1977)

The administration of anti-androgens brings favourable results especially in such skin diseases showing unsatisfactory therapeutic results, i.e. all severe forms of acne, seborrhoea, androgenic alopecia and hirsutism. Exact knowledge of the oestrogen and gestagen effect is essential. Also of fundamental importance is the observation and consideration of side effects besides the contraceptive efficacy and therapeutic results in dermatology.
Accomplishments and promise of transplutonium research (1984)

Fifty years ago the periodic table of chemical elements appeared to be complete. Most of the gaps left in the table by Dmitri Mendeleev in 1869 had been filled in, and it appeared that with elements 43, 61, 85, and 87, the periodic table of 92 elements—hydrogen to uranium—would be fully realized.
<title>Air-turbulence-compensated interferometer for IC manufacturing</title> (1995)

SPARTA has developed a novel dual wavelength interferometer which is directly aimed at stepper stage control and general IC metrology. It utilizes an existing HeNe based dual frequency interferometric system and couples it directly to a second system which provides the real time air turbulence compensation. The optical design provides for colinear optical beam paths for the two systems over the measurement path. Compensated position measurements are provided at a rate of 30 Hz which is sufficient to permit high throughput stage positioning for all modern steppers. Stage position accuracy is determined to 4 nm 3(sigma) and stage precision (which is a two pass operation) can be 5.6 nm 3(sigma) . Future improvements in performance can be expected since the present design is not near fundamental limits. The interferometric system design has a form factor compatible with existing stepper systems. Testing of this system has been carried out in a laboratory environment under a variety of conditions, including those which would simulate a clean room environment. Test results are used in detail and conclusions will be presented which define the impact this system can have on stepper overlay performance and IC metrology. Because the interferometer is the basic ruler upon which much of the stepper metrology, setup, and operation is based, an improvement in performance of this system provides numerous benefits in the areas of stage precision, alignment, lens metrology, and reticle qualification and fabrication. Furthermore, the elimination of air turbulence as a stepper design concern can permit improvements in stepper performance and throughput with fewer engineering compromises.
Metallic Ternary Telluride with Sphalerite Superstructure (2016)

A new ternary compound with composition Cu5Sn2Te7 has been synthesized using the stoichiometric reaction of Cu, Sn, and Te. The compound crystallizes in C2 space group with unit cell parameters of a = 13.549(2) Å, b = 6.0521(11) Å, c = 9.568(2) Å, and β = 98.121(2)°. Cu5Sn2Te7 is a superstructure of sphalerite and exhibits tetrahedral coordination of Cu, Sn, and Te atoms, containing a unique adamantane-like arrangement. The compound is formally mixed valent with a high electrical conductivity of 9.8 × 10(5) S m(-1) at 300 K and exhibits metallic behavior having p-type charge carriers as indicated from the positive Seebeck coefficient. Hall effect measurements further confirm holes as charge carriers with a carrier density of 1.39 × 10(21) cm(-3) and Hall mobility of 4.5 cm(2) V(-1) s(-1) at 300 K. The electronic band structure calculations indicate the presence of a finite density of states around the Fermi level and agree well with the p-type metallic conductivity. Band structure analysis suggests that the effective mass of the hole state is small and could be responsible for high electronic conductivity and Hall mobility. The high thermal conductivity of 15.1 W m(-1) K(-1) at 300 K coupled with the low Seebeck coefficient results in a poor thermoelectric figure of merit (ZT) for this compound. Theoretical calculations indicate that if Cu5Sn2Te7 is turned into a valence precise compound by substituting one Cu by a Zn, a semiconducting material, Cu4ZnSn2Te7, with a direct band gap of ∼ 0.5 eV can be obtained.
Evaluation of the splenic vein diameter and longitudinal size of the spleen in patients with Gamna-Gandy bodies. (2006)

The splenic vein diameter and longitudinal size of the spleen in portal hypertensive patients with Gamna- Gandy bodies are significantly larger than that of cirrhotic patients without Gamna-Gandy bodies and that of control group.
Engineering Thermoplastics for Additive Manufacturing: A Critical Perspective with Experimental Evidence to Support Functional Applications (2017)

Background Among additive manufacturing techniques, the filament-based technique involves what is referred to as fused deposition modeling (FDM). FDM materials are currently limited to a selected number of polymers. The present study focused on investigating the potential of using high-end engineering polymers in FDM. In addition, a critical review of the materials available on the market compared with those studied here was completed. Methods Different engineering thermoplastics, ranging from industrial grade polycarbonates to novel polyetheretherketones (PEEKs), were processed by FDM. Prior to this, for innovative filaments based on PEEK, extrusion processing was carried out. Mechanical properties (i.e., tensile and flexural) were investigated for each extruded material. An industrial-type FDM machine (Stratasys Fortus® 400 mc) was used to fully characterize the effect of printing parameters on the mechanical properties of polycarbonate. The obtained properties were compared with samples obtained by injection molding. Finally, FDM samples made of PEEK were also characterized and compared with those obtained by injection molding. Results The effect of raster to raster air gap and raster angle on tensile and flexural properties of printed PC was evidenced; the potential of PEEK filaments, as novel FDM material, was highlighted in comparison to state of the art materials. Conclusions Comparison with injection molded parts allowed to better understand FDM potential for functional applications. The study discussed pros and cons of the different materials. Finally, the development of novel PEEK filaments achieved important results offering a novel solution to the market when high mechanical and thermal properties are required.
Semantic Labeling of Multimedia Content Clusters (2006)

In this paper we present a novel approach for labeling clusters of multimedia content that leverages supervised classification techniques in conjunction with unsupervised clustering. Recent research has produced significant results for automatic tagging of video content such as broadcast news. For example, powerful techniques have been demonstrated in the context of the NIST TRECVID video retrieval benchmark [1]. However, the information needs of users typically span a range of semantic concepts. One of the challenges of these multimedia retrieval systems is to organize the video data in such a way that allows the user to most efficiently navigate the semantic space for the video data set. One important tool for video data organization is clustering. However, clustering results cannot be leveraged effectively when they are not labeled. We propose to build on clustering by aggregating the automatically tagged semantics. We propose and compare four techniques for labeling the clusters and evaluate the performance compared to human labeled ground-truth. We present examples of the cluster labeling results obtained on the BBC stock shots from the TRECVID-2005 video data set.
Ubiquitin-immunoreactive Dystrophic Neurites in Downʼs Syndrome Brains (1991)

Ubiquitin-immunoreactivity was studied in Down's syndrome brains ranging in age from two days to sixty years. Numerous randomly distributed ubiquitin-immunoreactive dot-like structures in the white matter were shown to correspond to granular degeneration of myelin. Granular degeneration of myelin was first detected at age 21 and increased thereafter with age. Other larger and more coarsely granular ubiquitin-immunoreactive structures, most numerous in the middle and upper cortical layers, were consistent with dystrophic neurites. Immunoelectron microscopy demonstrated that the dystrophic neurites contained non-filamentous, membranous, dense bodies. In Down's syndrome, ubiquitin-immunoreactive dystrophic neurites were first detected at age six in the hippocampus, and were consistently more numerous in comparison to age-matched control subjects. In the presence of amyloid, either as diffuse or as compact deposits, ubiquitin-immunoreactive dystrophic neurites frequently formed aggregates consistent with senile plaques. Although apparently independent events, these data suggest that amyloid deposition is associated with local accentuation of ubiquitin-immunoreactive neuritic dystrophy. In addition, since dystrophic neurites appeared substantially earlier in the grey matter in Down's syndrome than in age-matched normals, this may be further evidence that selective aspects of aging are accelerated in Down's syndrome.
Loading Dependent Structural Model of Polymeric Micelles by Solid-State NMR (2019)

Physically loaded polymeric micelles - from bulk properties to a molecular level understanding: In this work, solid-state NMR complemented by PXRD and quantum chemical calculations is used to learn about the short range order and structural arrangement in polymeric micelles formed by amphiphilic triblock copolymers. From changes in chemical shift and line widths, we could observe that at higher loadings, not just the micellar core but also the hydrophilic corona is involved in coordination of poorly soluble guest molecules, which can explain the poorer dissolution properties. This can serve as a platform for the future, targeted modification of such polymers. &lt;br&gt;
Eccentric Inlet Port of the Pivot Bearing Supported Gyro Centrifugal Pump (1997)

An eccentric inlet port is a unique feature of the pivot bearing supported Gyro Compact-1 Eccentric Inlet Port Model 3 (C1E3) centrifugal pump, a completely sealless centrifugal pump. The latest C1E3 has an eccentric inlet port with a 30 degree vertical angle. To investigate the adequacy of this 30 degree angle, flow visualization studies and in vitro hemolysis tests were performed, comparing 4 pumps, each with a different angle of the eccentric inlet port (0, 30, 60, and 90 degrees). The flow visualization study utilizing a tracer method focused on the flow pattern just distal to the inlet port of each pump, and each pump was operated at 5 L/min against 100 mm Hg and 5 L/min against 350 mm Hg. In the pumps with angles of 90 and 60 degrees, the flow direction changed horizontally, causing a vortex formation. In the pump with the 30 degree angle, the inflow did not change its course, resulting in minimal space for vortex formation. In the pump with the 0 degree angle, the inflow collided with the pump housing, resulting in a small vortex formation along the housing surface. The in vitro hemolysis tests at 5 L/min against 350 mm Hg revealed that the pump with the 30 degree angle was the least hemolytic and the pump with the 90 degree angle was the most hemolytic among the 4 pumps. These results suggest that the angle of the eccentric inlet port of the Gyro C1E3 pump should be 30 degrees to have less vortex formation and less red blood cell trauma.
Characterization of the tumor microenvironment landscape and deep learning-guided prediction of prognosis in lung adenocarcinoma with bulk RNA sequencing data. (2020)

e21025 Background: The tumor microenvironment (TME) plays an important role in tumor progression and treatment response, therefore profoundly affecting patient outcomes. Efforts to characterize the TME in lung adenocarcinoma are emerging but have been limited by the sample size and lack of treatment timepoints. Methods: We characterized changes in lung TME using the xCell algorithm to distinguish 64 immune and stroma cell types from bulk RNA sequencing data. The correlation between subtype cell population in lung TME and various clinical and biological characteristics was analyzed from over 500 lung adenocarcinoma (LUAD) samples from The Cancer Genome Atlas and an independent cohort of 48 advanced LUAD patients with treatment annotations (treatment-naive, residual disease, and progressive disease). In addition, we used key features in lung TME to predict prognosis using deep learning algorithms. Results: We found significant changes in both immune and stroma cell populations according to various clinical parameters such as smoking history, cancer stage, and treatment status. Specific sub-populations within lung TME correlate with survival outcomes based on Kaplan-Meier survival analyses. CD4- and CD8-positive T-cells are enriched in early stage disease and depleted in late stage disease, suggesting evolution of the TME during cancer progression. Consistent with previous reports, scores of immune cell populations associated with worse survival, such as T helper type 2 cells, are increased in late stage disease. Smoking history also reshapes the lung TME as populations correlated with better survival are decreased in smokers. We also found variations in sub-populations according to the driver oncogenes, with a less abundant lymphoid compartment in EGFR mutant samples compared to KRAS driven samples. Interestingly, we found higher scores of macrophage populations in residual disease following targeted-therapy treatment compared to pre-treatment. Finally, using machine and deep learning methods we identified a panel of 12 key features within the lung TME which could be used to predict prognosis. Conclusions: We comprehensively characterized immune and stroma cell type changes in the lung TME utilizing bulk RNA-seq data, and evaluated the association of sub-type cell populations with different clinical and biological features. Key features in lung TME could be used to predict prognosis.
Acoustic imaging of reservoir structure from a horizontal well (1998)

Recent advances in well-placement technology now allow a borehole to be steered with considerable precision inside the reservoir. With modern completion technology, the subsequent flow of hydrocarbons within the reservoir can be controlled to a greater extent than ever before. These developments have further emphasized the need for an improved ability to image structures such as caprock, stringers, faults, fractures, and pore-fluid contacts, on the reservoir scale.
Activation of the P2Y2 receptor enhances osteoclast function by stimulating the release of ATP, a pro-resorptive extracellular nucleotide (2014)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Supplementary Method from Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma (2023)

&lt;p&gt;Supplementary Methods, compound synthesis, Supplementary Materials and Supplementary References&lt;/p&gt;
Effects of auxins and immobilization on growth and purine alkaloids production in coffee (Coffea arabica L.) cell suspension culture. (1989)

コーヒーノキ (Coffea arabica L.) 培養細胞は, プリンアルカロイドであるカフェインおよびテオブロミンを生産し, その70～90%を培地中に放出した. カフェイン生産量はオーキシンの種類によって影響を受け, 3-indole butyric acid; 2mg/l kinetin; 0.1mg/lを含むMS基本培地 (B2K培地) において最大であり, 全体で43.1mg/flask, 培地中の濃度は131mg/lであった. アルギン酸カルシウムゲルで包括固定化した細胞は4代目まで培養可能であり, この場合は成長培地として用いた2,4-D; 1mg/l, kinetin; 0.1mg/lを含むMS基本培地 (DK培地) で4代目に最も高い生産量を示した.
Microbial resistance to the heavy metal pollution (2008)

their small size and abundance. The acute and chronic effects from exposure to this dust have not been well studied nor has the dust been characterized as to its chemical composition, mineral content, or microbial flora. Experiments were designed to study the Middle East dust as to its physical, chemical, and biological characteristics. Kuwaiti and Iraqi dust samples from different locations were collected and processed. Initial chemical and physical characterization of each sample including particle size distribution and inorganic analysis was conducted using ICP-MS for 57 different elements. Finally, characterization of biologic flora was performed using classical microbiological and molecular techniques to identify microbes and fungi. The results from this study suggest that further research may be warranted to provide insight into potential health risks.
The Influence of Liquid Menisci on Nanoparticle Dosimetry in Submerged Cells (Small 29/2023) (2023)

Submerged Cells The formation of a liquid meniscus in submerged cell cultures is common, but its impact on in vitro particle dosimetry has been overlooked. In article number 2206903, through experiments and mathematical modeling, Sandor Balog, Alke Petri-Fink, and co-workers identify key factors influencing nanoparticle dose and observe a significant gradient formation between the center and the wall of cell culture plates.
A Laminated Plate Model of an Adhesive-Bonded Taper-Taper Joint Under Tension (1997)

An analytical model of the strain and stress distributions in a taper-taper adhesive-bonded joint between two composite flat plates has been developed using first-order laminated plate theory. A correction for transverse shear deformation effects was included. The model was derived under the assumption of plane strain in the adherends and consists of eighteen first-order, linear, coupled ordinary differential equations with variable coefficients. The model was solved numerically using the Linear Shooting Method. Finite element models were also developed to verify the results of the analytical model using the COSMOS/M commercial software package.
ChemInform Abstract: REGIOSPEZIFITAET UND STEREOCHEMIE BEI DER HYDROALUMINIERUNG UNSYMMETRISCHER ACETYLENE, KONTROLLIERTE CIS‐ ODER TRANS‐REDUKTION VON 1‐ALKINYL‐DERIVATEN (1972)

Abstract Die Acetylene (I) reagieren mit Diisobutylaluminiumhydrid (II) zu den Addukten (III)‐(V), deren jeweilige Anteile unter den verschiedensten Bedingungen bestimmt werden.
Exploring rotation-translation coupling for a confined asymmetric rotor using molecular dynamics simulations: the case of the water molecule trapped inside a rare gas matrix (2020)

Differences between gas-phase and matrix-isolated rotational and rovibrational spectra of the water molecule are interpreted in term of the confined rotor model. The parameters of this model enable the isotopic composition of the molecule, which has non-trivial impacts on the spectra of matrix-isolated confined rotors, to be taken into account on a very simple and intuitive basis. We use molecular dynamics simulations to systematically explore the effects of the mass distribution of various isotopomers of the water molecule on the coupled rotational and translational dynamics of the confined asymmetric rotor, and on their coupling with the phonons of the argon matrix. Analysis of the trajectories reveals that, depending on the mass distribution, a preferred orientation of the water molecule can be strongly imposed by the topology of its interaction potential with the confinement medium. Features of the confining potential, and of the rotation-translation coupling, are thus revealed from classical molecular dynamics simulations.
Berlin‐Adlershof‐ chemische Forschung neu positioniert (2002)

Abstract Die Chemie ist nach einer Umbruchphase im Zuge der Wiedervereinigung nun fest in Berlin‐Adlershof etabliert. Neben vier außeruniversitären Forschungsinstituten, die sich mit chemierelevanten Fragen befassen, bildet das Institut für Chemie der Humboldt‐Universität zu Berlin, dessen Umzug auf den Adlershofer Campus im Herbst 2001 abgeschlossen wurde, einen Eckpfeiler für Ausbildung und Forschung. Die örtliche Nähe der verschiedenen Einrichtungen wird zu neuen Kontakten und Kooperationen führen.
THERMORESPONSIVE NANOFIBRES FOR ENGINEERING EXTRACELLULAR MATRIX-RICH TISSUE SUBSTITUTES (2018)

Tissue engineering by self-assembly offers the possibility to fabricate contiguous cell sheets that are stabilised by intact cell-cell contacts and endogenously produced extracellular matrix (ECM) ...
Ernesto: The Untold Story of Hemingway in Revolutionary Cuba (2019)

Comprehensive biography of Hemingway’s life in Cuba, covering his initial visit with second wife Pauline Pfeiffer in 1928, move to the fishing village of Cojimar with third wife Martha Gellhorn in 1940, and eventual adoption of the island as his second homeland in later years. Feldman discusses Hemingway’s love for the Cuban people, literary debt to Cojimar’s villagers in the writing of The Old Man and the Sea, longtime liaison with Leopoldina Rodriguez, friendships with Cuban writers, neighbors, and fishermen, relationship with Castro, and support of the revolution. Feldman’s examination deftly situates the author and his works (e.g. To Have and Have Not, The Old Man and the Sea, Islands in the Stream) within the island’s complex and changing political, social, and cultural landscapes, drawing on archives from the Hemingway Museum and Library in Havana and John F. Kennedy Library in Boston, biographies, memoirs, histories, correspondence, and other resources. Features over twenty black-and-white photographs. Includes extensive notes and critical bibliography and helpful index.
Androgens and Bone Health (1998)

Osteoporosis is one of the most common metabolic bone diseases in the adult population and its prevalence will continue to rise as our population grows older. In both sexes, hypogonadism is associated with accelerated loss of bone and development of osteoporosis. Adrenal and gonadal androgen levels decline with advancing age in both sexes. Androgens act by either directly binding to androgen receptors, or by aromatization of androgens to estrogens and subsequently interacting with estrogen receptors. Both pathways are important for skeletal health. Direct androgen binding to an androgen receptor may play a more important role in early skeletal development and determination of sexual dimorphic traits. While bone remodeling, which is important in maintaining healthy bone through life, is primarily stimulated by estrogen, studies in the rat and human support the complex action of androgens and estrogens in bone modeling and remodeling, and hence the development and maintenance of healthy bone. In postmenopausal females, the addition of androgens to hormone replacement therapy results in significant additional improvement in bone mineral density compared to estrogen replacement alone. Accumulating evidence indicate that androgens play an important role in the health of bone and the potential benefit of adding these agents to hormone replacement regimens.
Gas separation process using membranes with permeate sweep to remove CO.sub.2 from gaseous fuel combustion exhaust (2012)

A gas separation process for treating exhaust gases from the combustion of gaseous fuels, and gaseous fuel combustion processes including such gas separation. The invention involves routing a first portion of the exhaust stream to a carbon dioxide capture step, while simultaneously flowing a second portion of the exhaust gas stream across the feed side of a membrane, flowing a sweep gas stream, usually air, across the permeate side, then passing the permeate/sweep gas back to the combustor.
Representativeness of the Get With The Guidelines–Stroke Registry (2011)

Despite substantial differences between GWTG-Stroke and non-GWTG-Stroke hospitals, Medicare beneficiaries with acute ischemic stroke entered in the GWTG-Stroke program were similar to other Medicare beneficiaries. These data suggest that the Medicare-aged GWTG-Stroke ischemic stroke admissions are generally representative of the national fee-for-service Medicare ischemic stroke population.