gebhart/patrepeval huggingface dataset:
Adipocinas: uma visão geral dos seus efeitos metabólicos (2014)

There is a growing body of evidence indicating that adipose tissue is an endocrine organ able to synthesize and secrete substances involved in the pathogenesis of insulin resistance, systemic inflammation and atherogenesis. The purpose of this article is to conduct a review of the adipokines, adipose tissue-derived substances that seem to be the link between obesity and metabolic and cardiovascular diseases. Adipokines manifest their effects through endocrine and paracrine mechanisms. They act as immunomodulators, altering the balance between pro and anti-inflammatory cytokines; influence insulin sensitivity, interfering with glycemic homeostasis; regulate the central mechanism of appetite control and energy expenditure, with direct consequences on body weight. Moreover, they have effects on vascular tone, cell proliferation and atherogenesis, which modify cardiovascular risk, and they influence other determinants of the metabolic syndrome, such as blood pressure, lipid profile and degree of hepatic steatosis and inflammation. Adipokines may be an interesting tool for clinical use. They serve as biomarkers of metabolic and atherosclerotic disorders, enabling early identification of individuals at increased cardiovascular risk. In addition, handling these substances has a therapeutic potential that should not be overlooked, as suggested by the use of inhibitors of dipeptidyl peptidase 4 for the treatment of diabetes or by human recombinant leptin in patients with genetic deficiency of this adipokine. The use of the latter in lipodystrophic patients, as well as administration of visfatin for myocardial reperfusion with proven benefits in experimental models, also appears to be promising.
Evaluation of the Levels of Peripheral CD3 + , CD4 + , and CD8 + T Cells and IgG and IgM Antibodies in COVID-19 Patients at Different Stages of Infection (2022)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the stimulatory levels of cellular-mediated immunity, which plays an essential role in controlling SARS-CoV-2 infection. In fact, several studies have shown the association of lymphopenia with severe COVID-19 in patients. The aim of this study is to investigate the response of the immune system, including cell-mediated immunity and antibody production, during different stages of SARS-CoV-2 infection. Peripheral blood and serum samples were collected from patients with moderate infection, patients under medication (hospitalized), patients who had recovered, and healthy individuals (<i>n</i> = 80). Flow cytometry analysis was performed on peripheral blood samples to determine the cellular immunity profile of each patient. The data showed a significant reduction in the levels of CD3<sup>+</sup>, CD4<sup>+</sup>, and CD8<sup>+</sup> T cells and CD45<sup>+</sup> cells in the moderate and under-medication groups, suggesting lymphopenia in those patients. Also, enzyme-linked immunosorbent assay (ELISA) was conducted on the serum samples to measure the levels of antibodies, including IgM and IgG, in each patient. The results revealed a significant increase in the levels of IgM in the moderate infection and under-medication patients, thus indicating the production of IgM during the first week of infection. Furthermore, changes in the levels of IgG were significantly detected among recovered patients, indicating therefore a remarkable increase during the recovery stage of SARS-CoV-2 infection and thus a strong humoral-mediated immunity. In summary, the results of this study may help us to understand the main role of the cellular immune responses, including CD3<sup>+</sup>, CD4<sup>+</sup>, and CD8<sup>+</sup> T cells, against SARS-CoV-2 infection. This understanding might support the development of SARS-CoV-2 treatments and vaccines in the near future. <b>IMPORTANCE</b> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 in China. This virus is a serious threat to people not only in China but also worldwide, where it has been detected in over 222 countries. It has been reported that ∼3.4% of SARS-CoV-2-infected patients have died. The significance of our study relies on the fact that an enzyme-linked immunosorbent assay and flow cytometry were used to measure the levels of antibodies and cellular immune response, respectively, from clinical samples of patients infected with SARS-CoV-2.
Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics (2017)

Detection of circulating tumor cells (CTC) in peripheral blood is indicative of early recognition of tumor progression and such an important biomarker for early diagnosis, staging, monitoring and prognosis of cancer. However, CTC are found in very low concentrations and reliable isolation of these rare cells is challenging. Microfluidics enables precise manipulation of fluids and cells and is ideal for cell sorting methods for clinical diagnostics. The thesis contributes towards the development of microfluidic based CTC isolation methods from peripheral blood. The methods are based on size and immunoaffinity. The first part of the thesis describes the phenomenon of inertial focusing for size based cell separation at high throughputs. In paper 1, we demonstrate continuous filtration of leukocytes from diluted blood, with an efficiency of 78% at a flow rate of 2.2ml/min. In the paper 2, separation of total and subpopulation of leukocytes with a purity of 86% for granulocytes and 91% for lymphocytes is demonstrated. Furthermore, cancer cells spiked into whole blood could be separated at a yield of 88%. Finally, in paper 3 and 4 we unravel parts of the unexplored elasto-inertial microfluidics and was utilized to precisely focus the cells, as part of an integrated optofluidic micro flow cytometer device, capable to simultaneously measure fluorescence and scattering of cells and particles at a rate of 2500 particles/sec (paper 4). Second part of the thesis focuses on acoustophoresis. In (paper 5), a multifunctional acoustic microdevice was developed for isolation of cancer cells from red blood cells with a separation efficiency of 92.4% and trapping efficiency of 93%. In (paper 6), microbubbles activated acoustic cell sorter was developed for affinity based cell separation. As a proof of principle, cancer cells in a suspension were separated at an efficiency of 75%. In the third part, using cellulose nano fibrils (paper 7), we demonstrate efficiently capture and release of cancer cells at a release efficiency of 95%. Finally, a novel, single step self-assembly of spider silk proteins is introduced inside microfluidic channels for effective capture of cancer cells with 85% capture efficiency and subsequent release of captured cells with 95% release efficiency (paper 8). The novel recombinant silk modified microfluidic device was validated using pancreatic cancer patients. In summary, we have developed different microfluidic based isolation technologies for the capture and characterization of CTC.
ChemInform Abstract: Generation of Tertiary and Quaternary Stereocenters Through Palladium‐Catalyzed Intramolecular Heck‐Type Reactions for the Stereocontrolled Synthesis of Pyrrolo[1,2‐b]isoquinolines. (2016)

Abstract Different 2‐alkenyl‐substituted pyrroles and pyrrolidines are investigated as cyclization precursors: Pd sources, ligands (chiral and achiral), bases and solvents are tested to produce an optimal result concerning the required stereocenters.
The design of an integrated hand and wrist mechanism (1992)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1992.
The Incidence and Cost of New Onset Hyperlipidemia Claims Among US Wait-Listed and Transplanted Renal Allograft Recipients (2010)

Background: Hyperlipidemia increases mortality and is common with kidney-disease. New-onset hyperlipidemia (NOHL) among patients wait-listed and after transplantation may impact costs and graft-survival of patients with kidney disease. Methods: Using the United States Renal Data System, we compared the costs to Medicare associated with or without NOHL in wait-listed patients in the second and first year pre-transplant and transplanted patients in the first and second year post-transplant. We also examined the impact on graft-survival of NOHL. Results: New onset hyperlipidemia was especially expensive when it occurred well before transplantation. When compared with individuals with no hyperlipidemia, patients with early onset hyperlipidemia cost an extra $15,228 in the two years before transplantation and an extra $14,673 in the two years following transplantation. As has been found in prior studies, patients without any NOHL had the worst graft survival rates. Conclusions: Although NOHL was associated with increased pre-and post-transplant costs, patients diagnosed with NOHL between the second year before and second year after transplantation experienced higher graft-survival rates than those without NOHL by 2-years post-transplantation. Prior studies attribute this relationship to inflammation and malnutrition, which result in lower cholesterol levels and worse outcomes.
Prevention and Management of Painful Neuroma (2006)

Painful neuroma is a common sequela of peripheral nerve injury which is usually resistant to pharmacologic treatment and requires surgical intervention. The widely accepted methods of neuroma management prevent regrowth of nerve fibers, thus precluding any functional repair. The present study reviews the currently used methods and experimental approaches to prevent and cure neuromas developing after peripheral nerve injury. The main recommendations are as follows. Special care should be taken to minimize scar formation when operating on peripheral nerves. The laser or scissors transection methods should be used to cut the nerve rather than electrocoagulation or cryoneurolysis. Direct nerve reconstruction, or, if a gap occurs, nerve grafting, should be performed immediately after nerve injury. Surgical resection of recurrent neuroma followed by implantation of the nerve into the muscle or capping the nerve stump with epineural graft seems to be the most effective method of prevention.
Aspect-Oriented Security and Exception Handling within an Object Oriented System (2011)

The object-oriented paradigm, with its characteristics of inheritance, modularity, and polymorphism, has facilitated software reuse. However, the modularity and inheritance characteristics of object-orientation, has posed problems in the area of exception handling in terms of code tangling, repetitive code, and the possibility of spoofed parent classes managing the exception. We propose a method to incorporate parts of aspect-oriented programming, specifically security and exception handling mechanisms, into an object-oriented system in order to increase its modularity and reuse, centralize its security and exception handling, and provide enhanced verification and security of resource access. At the end, a small example is presented to illustrate our approach. Our goal is to eventually develop a methodology and tool to help automate the migration of legacy object-oriented systems to the aspect-oriented paradigm, particularly in regards to exception handling and security.
A Case Study on Automated Fuzz Target Generation for Large Codebases (2019)

Fuzz Testing is a largely automated testing technique that provides random and unexpected input to a program in attempt to trigger failure conditions. Much of the research conducted thus far into Fuzz Testing has focused on developing improvements to available Fuzz Testing tools and frameworks in order to improve efficiency. In this paper however, we instead look at a way in which we can reduce the amount of developer time required to integrate Fuzz Testing to help maintain an existing codebase. We accomplish this with a new technique for automatically generating Fuzz Targets, the modified versions of programs on which Fuzz Testing tools operate. We evaluated three different Fuzz Testing solutions on the codebase of our industry partner and found a fully automated solution to result in significantly more bugs found with respect to the developer time required to implement said solution. Our research is an important step towards increasing the prevalence of Fuzz Testing by making it simpler to integrate a Fuzz Testing solution for maintaining an existing codebase.
Infrared Reflection Spectroscopy of Polycyanurate Thin Films on Solids–State of the Interphase (1995)

S.261-275
Familial Retinal Arteriolar Tortuosity (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Amino acid synthesis pathways in Desulfovibrio vulgaris (2009)

Several steps in amino acid synthesis pathways are not annotated in the Desulfovibrio vulgaris genome. We computationally predicted several new reactions, including isoleucine synthesis via citramalate synthase (DVU1914), methionine synthesis via a potential bifunctional cystathionine gamma-synthase and beta-lyase (DVU0171), synthesis of alpha-ketoglutarate and glutamate via an Re-citrate synthase (DVU0398), and synthesis of chorismate and aromatic amino acids via an archaeal-like transaldolase and 3-dehydroquinate cyclase/deaminase (DVU0460,DVU0461). We\nare using genetic knockouts and complementation assays to test these predictions.
Real-world effectiveness of COVID-19 vaccination in liver cirrhosis: a systematic review with meta-analysis of 51,834 patients (2023)

SARS-CoV-2 vaccinations were found to be highly effective in phase 3 clinical trials. However, these trials have not reported data regarding the subgroup of liver disease or excluded patients with liver disease. The effectiveness of COVID-19 vaccines among liver cirrhosis (LC) patients is unclear. We conducted this meta-analysis to assess the effectiveness of SARS-CoV-2 vaccination in LC patients. A comprehensive literature search was conducted to include all the relevant studies that compared the outcomes of LC patients who received SARS-CoV-2 vaccines vs. unvaccinated patients. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated by the Mantel-Haenszel method within a random-effect model. Four studies with 51,834 LC patients (20,689 patients received at least one dose vs 31,145 were unvaccinated) were included. COVID-19-related complications, including hospitalization (RR 0.73, 95% CI 0.59-0.91, <i>P</i> = 0.004), mortality (RR 0.29, 95% CI 0.16-0.55, <i>P</i> = 0.0001), and need for invasive mechanical ventilation (RR 0.29, 95% CI 0.11-0.77, <i>P</i> = 0.01), were significantly lower in the vaccinated group compared to the unvaccinated group. SARS-CoV-2 vaccination in LC patients reduced COVID-19-related mortality, intubation, and hospitalization. SARS-CoV-2 vaccination is highly effective in LC. Further prospective studies, preferably randomized controlled trials, are necessary to validate our findings and determine which vaccine is superior in patients with LC.
ChemInform Abstract: Development of Recyclable Iridium Catalyst for C—H Borylation. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quality of life and sexuality of patients after treatment for gynaecological malignancies: results of a prospective study in 55 patients. (2012)

Evaluation of sexuality and self image perception after cancer treatment is an unmet need and needs to be addressed in women with gynaecological malignancies. Further studies are warranted to assess the influence of the various types of cancer therapies in regard to their effect on sexuality and quality of life.
Performance-Aware Replication of Distributed Pre-Recorded IPTV Content (2009)

Video recording in IPTV systems is a promising service that provides time-shifted services in relation to storing TV content closer to user devices such as set-top boxes. Existing approaches do not support collaboration between nodes which have correlated contents, a fact that can affect the performance of the overall system. To make this service more interactive and proactive, this paper presents the architecture using the smart personal information network (Smart PIN) as a novel performance-based content sharing network for IPTV content which uses a user-centric utility-based multimedia data replication scheme (MDRS). This allows the exchange of data based on both network performance and user interest in exchanged multimedia content in order to achieve efficient content sharing. The proposed solution is evaluated through extensive simulations and results show much improved behavior in comparison with two other existing general purpose data replication schemes.
ChemInform Abstract: Base Catalysis in the Willgerodt—Kindler Reaction. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The microprotein Minion controls cell fusion and muscle formation (2017)

Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be determined. Skeletal muscle development requires fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understood process. Here we report the identification of Minion (microprotein inducer of fusion), a smORF encoding an essential skeletal muscle specific microprotein. Myogenic progenitors lacking Minion differentiate normally but fail to form syncytial myotubes, and Minion-deficient mice die perinatally and demonstrate a marked reduction in fused muscle fibres. The fusogenic activity of Minion is conserved in the human orthologue, and co-expression of Minion and the transmembrane protein Myomaker is sufficient to induce cellular fusion accompanied by rapid cytoskeletal rearrangement, even in non-muscle cells. These findings establish Minion as a novel microprotein required for muscle development, and define a two-component programme for the induction of mammalian cell fusion. Moreover, these data also significantly expand the known functions of smORF-encoded microproteins.
Series array of incommensurate superconducting quantum interference devices from YBa2Cu3O7−δ ion damage Josephson junctions (2008)

We have fabricated a series array of 280 superconducting quantum interference devices (SQUIDs) using YBa2Cu3O7−δ thin film ion damage Josephson junctions. The SQUID loop areas were tapered exponentially so that the response of the current-biased array to magnetic field is a single voltage spike at zero field. We fitted the current-voltage characteristics of the array to a model in which we summed the voltages across the SQUIDs assuming a resistively shunted junction model with a normal distribution of SQUID critical currents. At 75 K the standard deviation of these critical currents was 12%.
Artificial Ears for a Biomimetic Sonarhead: From Multiple Reflectors to Surfaces (2001)

This work presents an evolutionary approach to pinna design. Narrowband echolocating bats move the pinna to alter the directional sensitivity of their perceptual systems. Adding pinnae to RoBat--a biomimetic sonarhead mounted on a mobile robot--is the goal of this work. After a description of the earlier work on artificial pinnae consisting of multiple reflectors around the transducer, an acoustic model, inspired by a physical model of sound diffraction and reflections in the human concha, is described and revisited as the model to use for evolving complex shapes. A genetic algorithm evolved the shape of the pinnae with respect to desired features of the directivity pattern of the receiver transducers. Some interesting paraboloid shapes for specific echolocating behaviors were evolved, improving performance with respect to the bare transducer's performance.