gebhart/patrepeval huggingface dataset:
Development of a System to Measure Micro Hole Form Accuracy Using an Optical Fiber Probe (2nd Report) (2010)

This paper presents a micro hole measuring system using an optical fiber probe. The system is composed of a fiber probe, two floodlighting fibers and two double-light reception fibers in the X and Y directions. The fiber probe has an optical fiber of 30μm in diameter with a ball of 50μm in diameter on the end. The probe is deflected when it comes into contact with a hole surface, and this deflection is measured optically. In this research, the accuracy and repeatability of such measurement are examined by measuring a roughness standard specimen and a micro hole. The results clarified that the accuracy of the roughness standard specimen measured by the measuring system corresponds well to that of the surface roughness tester in both shape and value and that the maximum repeatability errors for 10 measurements of a roughness standard specimen is within ±0.03 μm in scanning mode and ±0.1 μm in touch trigger mode.
Data from Late-Stage Tumor Regression after PD-L1 Blockade Plus a Concurrent OX40 Agonist (2023)

&lt;div&gt;Abstract&lt;p&gt;The protective capability of tumor antigen–specific T cells is regulated by costimulatory and inhibitory signals. Current approaches in cancer immunotherapy seek to restore the function of unresponsive T cells by blocking inhibitory pathways. In contrast, providing exogenous costimulatory signals to T cells also enhances antitumor functionality. By combining these two clinical approaches, we demonstrate the synergy of targeting PD-L1 together with the costimulatory molecule OX40, to enhance antitumor immunity. Concurrently blocking PD-L1 and providing a costimulatory agonist to OX40 increased the presence and functionality of tumor antigen–specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells with simultaneous enhancement of T-helper type 1 (Th1)-skewed CD4&lt;sup&gt;+&lt;/sup&gt; T cells. This shift was functionally supported by increased glucose metabolism of antigen-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells and the acquisition of granzyme B by regulatory T cells. Together, this mechanism promoted tumor regression of late-stage tumors beyond that achieved by either blockade as monotherapy. These findings indicate that targeting both T-cell intrinsic (OX40) and extrinsic (PD-L1) regulatory molecules increases the bioenergetic potential of T cells, thereby expanding functional and tumor antigen–specific T cells.&lt;/p&gt;&lt;/div&gt;
Energy Optimization on Offshore Installations with Emphasis on Offshore Combined Cycle Plants (1999)

Abstract Increasing fuel cost and concern regarding emissions have incurred focus on energy conservation on offshore oil and gas installations. On the Norwegian continental shelf there has been an increased commercial value of natural gas and a CO2-tax on fuel consumption the last 10 years. For the time being the alternative value of natural gas is in the range 0 to 0.08 EUR/Sm3 and consumption of fuel is taxed with approx. 0.1 EUR/Sm3 burned. This has brought forward significant changes in operational procedures and technology development on the Norwegian oil and gas installations compared to installations in other oil and gas regions throughout the world. Focus has increased on keeping the power requirement down, avoiding unnecessary fuel consumption and designing more energy efficient systems. The most efficient way of achieving this is by installing cold process flares and steam cycles on existing or new gas turbines to form Combined Cycles (CC). In Norway three steam cycle plants fueled by gas turbine exhaust are under completion on offshore oil and gas installations. The overall electrical efficiency of these plants is around 50%. When steam is extracted for process heat the overall thermal efficiency is higher. Compared to conventional simple cycles the combined cycle reduces consumption of fuel gas and emissions of CO2 and NOX with minimum 25%. When designed as alternative to conventional simple cycle solutions, a combined cycle represents an alternative investment reducing the size and/or the number of gas turbines needed. This gives a good contribution to the overall Life Cycle evaluation in favor of the combined cycle option when compared to the simple cycle option.
Microsoft azure SQL database telemetry (2015)

Microsoft operates the Azure SQL Database (ASD) cloud service, one of the dominant relational cloud database services in the market today. To aid the academic community in their research on designing and efficiently operating cloud database services, Microsoft is introducing the release of production-level telemetry traces from the ASD service. This telemetry data set provides, over a wide set of important hardware resources and counters, the consumption level of each customer database replica. The first release will be a multi-month time-series data set that includes the full cluster traces from two different ASD global regions.
Structure-function relationships for the IL 2-receptor system. II. Localization of an IL 2 binding site on high and low affinity receptors. (1986)

The ligand-binding component of high and low affinity IL 2 receptors is a 55,000 m.w. glycoprotein termed Tac. Correlating the structure and function of this molecule should provide insight into the mechanism of IL 2-initiated signal transduction and the structural basis for high and low affinity receptor forms. As a first step in this process, various approaches were used to localize the IL 2 binding region of the Tac molecule. Antibodies prepared to synthetic fragments of Tac were tested for their ability to interfere with IL 2 binding and bioactivity. The results delineated segments in the C-terminal portion of the molecule which appeared to be distal to the ligand binding site. In a more direct approach, radioiodinated IL 2 was cross-linked to high and low affinity receptors, and the resulting complexes were subjected to mild tryptic digestion. Consistent with the antibody data, the IL 2 remained covalently associated with an N-terminal tryptic fragment which apparently consisted of residues 1-83 of the Tac protein. These results suggest that the N-terminal region of the Tac molecule contains important contact sites for ligand-receptor interaction.
Photoaging Skin Therapy with PRP and ADSC: A Comparative Study (2020)

Background . Stem cells from adipose tissue (ADSCs) and platelet-rich plasma (PRP) are innovative modalities that arise due to their regenerative potential. Objective . The aim of this study was to characterize possible histological changes induced by PRP and ADSC therapies in photoaged skin. Methods . A prospective randomized study involving 20 healthy individuals, showing skin aging. They underwent two therapeutic protocols (protocol 1: PRP; protocol 2: ADSCs). Biopsies were obtained before and after treatment (4 months). Results . PRP protocol showed unwanted changes in the reticular dermis, mainly due to the deposition of a horizontal layer of collagen (fibrosis) and elastic fibers tightly linked. Structural analyses revealed infiltration of mononuclear cells and depot of fibrotic material in the reticular dermis. The ADSC protocol leads to neoelastogenesis with increase of tropoelastin and fibrillin. There was an improvement of solar elastosis inducing an increment of macrophage polarization and matrix proteinases. These last effects are probably related to the increase of elastinolysis and the remodeling of the dermis. Conclusions . The PRP promoted an inflammatory process with an increase of reticular dermis thickness with a fibrotic aspect. On the other hand, ADSC therapy is a promising modality with an important antiaging effect on photoaged human skin.
Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis (2021)

Cells have evolved extensive signaling mechanisms to maintain redox homeostasis. While basal levels of oxidants are critical for normal signaling, a tipping point is reached when the level of oxidant species exceed cellular antioxidant capabilities. Myriad pathological conditions are characterized by elevated oxidative stress, which can cause alterations in cellular operations and damage to cellular components including nucleic acids. Maintenance of nuclear chromatin are critically important for host survival and eukaryotic organisms possess an elaborately orchestrated response to initiate repair of such DNA damage. Recent evidence indicates links between the cellular antioxidant response, the DNA damage response (DDR), and the epigenetic status of the cell under conditions of elevated oxidative stress. In this emerging model, the cellular response to excessive oxidants may include redox sensors that regulate both the DDR and an orchestrated change to the epigenome in a tightly controlled program that both protects and regulates the nuclear genome. Herein we use sepsis as a model of an inflammatory pathophysiological condition that results in elevated oxidative stress, upregulation of the DDR, and epigenetic reprogramming of hematopoietic stem cells (HSCs) to discuss new evidence for interplay between the antioxidant response, the DNA damage response, and epigenetic status.
A Restful Architecture for Web-based Smart Homes using Request Queues (2012)

This technical report describes the architecture of a Web-based smart home framework, which may be used as the backbone of future smart home deployments. This framework has been designed to support multiple family members and concurrent invocation of embedded home appliances, sensors and actuators. A fundamental element of the framework’s architecture is the use of request queues, for better managing the communication with home devices, ensuring reliability, fault-tolerance and time efficiency. By means of the requests queues, prioritized requests may be easily supported, by transforming the queues into priority heaps. The framework has been designed following the REST architectural style, in order to offer a Web-based behaviour and address the increased heterogeneity of resource-constrained home devices. Through this report, the design and implementation of this Web-based framework for smart homes is presented, along with an analysis of its important components. Finally, a technical evaluation is
Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current (2017)

Action potential (AP) shape is a key determinant of cellular electrophysiological behavior. We found that in small-diameter, capsaicin-sensitive dorsal root ganglia neurons corresponding to nociceptors (from rats of either sex), stimulation at frequencies as low as 1 Hz produced progressive broadening of the APs. Stimulation at 10 Hz for 3 s resulted in an increase in AP width by an average of 76 ± 7% at 22°C and by 38 ± 3% at 35°C. AP clamp experiments showed that spike broadening results from frequency-dependent reduction of potassium current during spike repolarization. The major current responsible for frequency-dependent reduction of overall spike-repolarizing potassium current was identified as Kv3 current by its sensitivity to low concentrations of 4-aminopyridine (IC<sub>50</sub> <100 μm) and block by the peptide inhibitor blood depressing substance I (BDS-I). There was a small component of Kv1-mediated current during AP repolarization, but this current did not show frequency-dependent reduction. In a small fraction of cells, there was a component of calcium-dependent potassium current that showed frequency-dependent reduction, but the contribution to overall potassium current reduction was almost always much smaller than that of Kv3-mediated current. These results show that Kv3 channels make a major contribution to spike repolarization in small-diameter DRG neurons and undergo frequency-dependent reduction, leading to spike broadening at moderate firing frequencies. Spike broadening from frequency-dependent reduction in Kv3 current could mitigate the frequency-dependent decreases in conduction velocity typical of C-fiber axons.<b>SIGNIFICANCE STATEMENT</b> Small-diameter dorsal root ganglia (DRG) neurons mediating nociception and other sensory modalities express many types of potassium channels, but how they combine to control firing patterns and conduction is not well understood. We found that action potentials of small-diameter rat DRG neurons showed spike broadening at frequencies as low as 1 Hz and that spike broadening resulted predominantly from frequency-dependent inactivation of Kv3 channels. Spike width helps to control transmitter release, conduction velocity, and firing patterns and understanding the role of particular potassium channels can help to guide new pharmacological strategies for targeting pain-sensing neurons selectively.
Safety and efficacy of OptiPhos® PLUS (6 phytase) for laying hens, turkeys for breeding, chickens for breeding, minor poultry species for egg production purposes and breeding (2020)

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of OptiPhos PLUS <sup>®</sup>, intended to be used as a feed additive for laying hens, turkeys for breeding, chickens for breeding, minor poultry species for egg production purposes and breeding. The active substance is 6-phytase produced by a genetically modified strain of <i>Komagataella phaffii</i>. The EFSA FEEDAP Panel concluded that the genetic modification of the production strain does not give rise to safety concerns. Based on the tolerance studies provided, the Panel concluded that the additive is safe for the target species under the conditions of use with a wide margin of safety. The additive was considered safe also for the consumer and the environment. The additive is not a skin irritant but is a dermal sensitiser. The FEEDAP Panel could not conclude on the eye irritation potential of the additive. Owing to the proteinaceous nature of the active substance, the additive is considered a respiratory sensitiser. The FEEDAP Panel concluded that the additive has the potential to be efficacious in increasing the phosphorus utilisation in laying hens at the level of 250 FTU/kg feed. These conclusions were extended to turkeys for breeding and chickens for breeding and extrapolated to minor poultry species for egg production purposes and breeding.
Clinical, haematological and cytogenetic features in 24 patients with structural rearrangements of the Q arm of chromosome 3 (1993)

To determine the frequency and clinical significance of acquired abnormalities of chromosome 3 at q21 and q25-26 in haematological malignancy, we reviewed the haematological and cytogenetic features of 24 patients with a 3q rearrangement identified amongst 1200 cases with clonal cytogenetic abnormalities detected at our institutions during a 12-year period. Thirteen patients presented with de novo acute myeloid leukaemia (AML), 10 with myelodysplasia (MDS) and one in blast phase of chronic myelogenous leukaemia. Twenty patients (83%) had megakaryocytic dysplasia and 14 (58%) had normal or increased numbers of megakaryocytes, but only four patients (16%) had absolute thrombocytosis > 500 x 10(9)/l (three with AML, one with MDS transforming to AML). A review of 205 cases of AML investigated in our institutions between 1985 and 1990 for whom cytogenetic results were obtained revealed that a platelet count > 500 x 10(9)/l at presentation was highly suggestive of an underlying 3q abnormality. A limited review of the literature on this subject confirmed that 15-20% of patients with a 3q abnormality will have thrombocytosis. The response of these patients to conventional antileukaemic therapy is uniformly poor, despite haematological and clinical differences between the subtypes of 3q rearrangements.
A Linear Program for System-Level Control of Regional PHEV Charging Stations (2016)

This paper studies dynamic control of a system of plug-in hybrid electric vehicle (PHEV) charging stations. A finite horizon stochastic program is presented. Based upon the 15-min updated period of the electricity market price, the objective function is to maximize profit, which is the revenue benefit from selling back to the grid and the charging of the vehicles minus the cost of buying electricity from the grid. The state variables in each 15-min time period consist of the total wind purchased from the system, solar power generation at each charging station, total demand at each station, and nodal market price at stations' location. A stochastic program is formulated, and the mean value problem as a deterministic linear program is solved. Potential strategies are presented to provide insight into the behavior of the system.
Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies (2021)

Abstract Clinically approved for the treatment of diabetes and obesity, glucagon‐like peptide‐1 (GLP‐1) receptor agonists display prominent glucose‐ and weight‐lowering effects as well as positive cardioprotective and neuroprotective actions. Despite these benefits, bariatric surgery remains superior in producing robust and sustained weight loss alongside improvements in metabolic control with possible diabetes remission. The current review considers the potential for adjunct therapies to augment the therapeutic actions of GLP‐1 receptor agonists. In this regard, several gut‐derived hormones also, modulated by bariatric surgery, display additive properties when combined with GLP‐1 receptor agonists in both preclinical and clinical studies. In addition, glucocorticoids and oestrogen have shown promise in augmenting the biological actions of GLP‐1 in animal models. Additionally, GLP‐1 efficacy can also be enhanced by use of compounds that prolong GLP‐1 receptor coupling to potentiate downstream receptor signalling. Taken together, therapies that activate GLP‐1 receptor signalling, in combination with various other cell signalling pathways, show potential for treating type 2 diabetes and obesity with superiority over GLP‐1 receptor agonist therapy alone.
Figure S11 from 3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening (2023)

&lt;p&gt;COMPUSYN analyses for paclitaxel and vincristine&lt;/p&gt;
The NASA GSFC 94-GHz Airborne Solid-State Cloud Radar System (CRS) (2021)

Abstract The NASA Goddard Space Flight Center’s (GSFC’s) W-band (94 GHz) Cloud Radar System (CRS) has been comprehensively updated to modern solid-state and digital technology. This W-band (94 GHz) radar flies in nadir-pointing mode on the NASA ER-2 high-altitude aircraft, providing polarimetric reflectivity and Doppler measurements of clouds and precipitation. This paper describes the design and signal processing of the upgraded CRS. It includes details on the hardware upgrades [solid-state power amplifier (SSPA) transmitter, antenna, and digital receiver] including a new reflectarray antenna and solid-state transmitter. It also includes algorithms, including internal loop-back calibration, external calibration using a direct relationship between volume reflectivity and the range-integrated backscatter of the ocean, and a modified staggered–pulse repetition frequency (PRF) Doppler algorithm that is highly resistant to unfolding errors. Data samples obtained by upgraded CRS through recent NASA airborne science missions are provided.
Supporting operator reliance on automation through continuous feedback (2009)

In driving, multiple variables in automated systems such as adaptive cruise control (ACC) and active steering, and in the environment dynamically change and interact. This complexity makes it difficult for operators to track the activities and responses of automation. The inability of operators to monitor and understand automation’s behavior contributes to inappropriate reliance, i.e. when an operator uses automation that performs poorly or fails to use automation that is superior to manual control. The decision to use or not use automation is one of the most important an operator can make, particularly in time-critical or emergency situations, therefore it is essential that an operator is calibrated in their automation use. An operator’s decision to rely on automation depends on trust. System feedback provided to the operator is one means to calibrate trust in automation in that the type of feedback may differentially affect trust. The goal of this research is to help operators manage imperfect automation in real-time and to promote calibrated trust and reliance. A continuous information display that provides information on system behavior relative to its operating context is one means to promote such calibration. Three specific aims are pursued to test the central hypothesis of this dissertation that continuous feedback on the state and behavior of the automation informs operators of the evolving relationship between system performance and operating limits, therefore promoting accurate mental models and calibrated trust. The first aim applies a quantitative model to define the effect of understanding on driver-ACC interaction failures and to predict driver response to feedback. The second aim presents a systematic approach to define the feedback needed to support appropriate reliance in
Predicted and actual end-of-treatment occlusion produced with aligner therapy (2014)

ABSTRACT Objective: To compare three-dimensional (3D) ClinCheck™ models with the subjects' actual 3D posttreatment models using the American Board of Orthodontics Objective Grading System (OGS). Materials and Methods: This prospective, within-subject study included 27 consecutive cases treated with aligner therapy. The posttreatment plaster models taken immediately after treatment were scanned and converted to stereolithography (STL) files; the ClinCheck models were also converted to STL format. MeshLab software was used to measure the seven components of the OGS, including alignment, marginal ridges, buccolingual inclinations, occlusal contacts, occlusal relationships, overjet and interproximal contacts. An overall OGS deduction score was also calculated. Results: Compared with the posttreatment models, the ClinCheck models showed significantly ( P = .016) fewer overall OGS point deductions (24 vs 15). These overall differences were due to significantly ( P &lt; .05) more deductions among the posttreatment models than the ClinCheck models for alignment (4.0 vs 1.0 deductions), buccolingual inclinations (4.0 vs 3.0 deductions), occlusal contacts (3.0 vs 2.0 deductions), and occlusal relations (4.0 vs 2.0 deductions). Conclusion: The ClinCheck models do not accurately reflect the patients' final occlusion, as measured by the OGS, at the end of active treatment.
ChemInform Abstract: DICHLORO(1,2‐BIS(4‐HYDROXYPHENYL)ETHYLENEDIAMINE)PLATINUM(II) COMPLEXES: AN APPROACH TO DEVELOP COMPOUNDS WITH A SPECIFIC EFFECT ON THE HORMONE‐DEPENDENT MAMMARY CARCINOMA (1985)

Abstract Dargestellt und auf Antitumor‐Wirkung untersucht werden die Komplexe (ll).