gebhart/patrepeval huggingface dataset:
[Resectable bronchial cancer. Contribution of computed x-ray tomography in the evaluation of loco-regional extension]. (1986)

A prospective study of 107 patients was performed for assessing the CT contribution in preoperative staging of lung carcinoma. Thoracotomy was performed in all patients. The results demonstrated that CT is useful in all cases when surgery is indicated. Nevertheless CT gave not benefit in cases of peripheral small tumors T1N0 classified after standard chest radiograph and fibroscopy. The statistical analysis allowed to define the most accurate size criteria to declare mediastinal nodes as hypertrophied. Furthermore this study confirms that CT criteria of mediastinal and chest wall involvement have to be very strict.
Quantifying the health benefits of face masks and respirators to mitigate exposure to severe air pollution (2021)

Earth and Space Science Open Archive This work has been accepted for publication in GeoHealth. Version of RecordESSOAr is a venue for early communication or feedback before peer review. Data may be preliminary. Learn more about preprints. preprintOpen AccessYou are viewing the latest version by default [v2]Quantifying the health benefits of face masks and respirators to mitigate exposure to severe air pollutionAuthorsJohn K.KodrosiDKatelynO'DelliDJonathanSametChristianL'OrangeiDJeffrey R.PierceiDJohnVolckensiDSee all authors John K. KodrosiDCorresponding Author• Submitting AuthorColorado State UniversityiDhttps://orcid.org/0000-0003-1791-0118view email addressThe email was not providedcopy email addressKatelyn O'DelliDColorado State UniversityiDhttps://orcid.org/0000-0002-0198-6153view email addressThe email was not providedcopy email addressJonathan SametColorado School of Public Healthview email addressThe email was not providedcopy email addressChristian L'OrangeiDColorado State UniversityiDhttps://orcid.org/0000-0003-1905-8694view email addressThe email was not providedcopy email addressJeffrey R. PierceiDColorado State UniversityiDhttps://orcid.org/0000-0002-4241-838Xview email addressThe email was not providedcopy email addressJohn VolckensiDColorado StateiDhttps://orcid.org/0000-0002-7563-9525view email addressThe email was not providedcopy email address
Data from <i>In vitro</i> differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation (2023)

&lt;div&gt;Abstract&lt;p&gt;The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. We previously sequenced 24 cancer genes in those cell lines. Eleven of the genes were found to be mutated in three or more of the lines. Using a pharmacogenomic approach, we analyzed the relationship between drug activity and mutations in those 11 genes (&lt;i&gt;APC, RB1, KRAS, NRAS, BRAF, PIK3CA, PTEN, STK11, MADH4, TP53&lt;/i&gt;, and &lt;i&gt;CDKN2A&lt;/i&gt;). That analysis identified an association between mutation in BRAF and the antiproliferative potential of phenothiazine compounds. Phenothiazines have been used as antipsychotics and as adjunct antiemetics during cancer chemotherapy and more recently have been reported to have anticancer properties. However, to date, the anticancer mechanism of action of phenothiazines has not been elucidated. To follow up on the initial pharmacologic observations in the NCI-60 screen, we did pharmacologic experiments on 11 of the NCI-60 cell lines and, prospectively, on an additional 24 lines. The studies provide evidence that BRAF mutation (codon 600) in melanoma as opposed to RAS mutation is predictive of an increase in sensitivity to phenothiazines as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt assay (Wilcoxon &lt;i&gt;P&lt;/i&gt; = 0.007). That pattern of increased sensitivity to phenothiazines based on the presence of codon 600 BRAF mutation may be unique to melanomas, as we do not observe it in a panel of colorectal cancers. The findings reported here have potential implications for the use of phenothiazines in the treatment of V600E BRAF mutant melanoma. [Mol Cancer Ther 2008;7(6):1337–46]&lt;/p&gt;&lt;/div&gt;
Regulation of taurocholate and ursodeoxycholate uptake in hamster hepatocytes by Ca(2+)-mobilizing agents (1996)

In isolated hamster hepatocytes, the Ca2+ ionophore A-23187 immediately decreased the uptake rate of taurocholic acid (TCA) by 60-70%, whereas it slowly inhibited that of ursodeoxycholic acid (UDCA) by a maximum of 35-45%, with an inhibition constant (Ki) of 0.36 and 1.93 microM, respectively. In contrast to ionomycin, which mimicked the effect of A-23187, vasopressin inhibited the bile acid uptake rate by 40 and 45%, respectively, only after a 5- to 10-min preincubation. The Na(+)-dependent bile acid transport was exclusively inhibited by these agents, and this inhibition was independent of extracellular Ca2+. However, intracellular Ca2+ depletion with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid or chelation with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid resulted in 40-50% inhibition of the uptake rate of both bile acids. The exogenous protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), but not the nonactive 4 alpha-phorbol, significantly inhibited TCA uptake rate. Although both A-23187 and ionomycin immediately increased and decreased the cellular Na+ and K+ concentration, respectively, neither vasopressin nor PMA had a significant effect on the cellular concentration of these cations, even after a 10-min incubation. Furthermore, the effect of A-23187 and ionomycin on TCA uptake and Na+ flux, respectively, disappeared after a 40-min preincubation, and additional ionophore remained without effect. However, after a 40-min incubation with A-23187, PMA was still able to inhibit TCA uptake. Therefore, A-23187 and ionomycin transiently inhibited Na(+)-dependent uptake of both TCA and UDCA, in part because of transient alteration of the cellular Na+ and K+ concentration. Vasopressin and PMA inhibited Na(+)-dependent bile acid uptake, at least in part, through protein kinase C activation.
Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation (2013)

Serum FSH and LH governing the natural ovarian stimulation process exhibited dynamic changes of glycosylation and glycan composition. This new information on the FSH and LH molecular structures may lead to more successful mono-ovulatory treatment regimens for ovulation induction in anovulatory women.
Novel O-GEHL Based Hyperblock Predictor for EDGE Architectures (2012)

Control flow speculation plays a pushing role to the performance of block-atomic EDGE architectures. Hyperblock predictors, which leverage the style of "Exit + Target" to predict the next hyperblock address, enable high efficient hyperblock-level control flow speculation for EDGE architectures. Recently, a series of binary prediction techniques have been studied and modified to adapt for the exit predictor in hyperblock predictors, including the O-GEHL prediction technique, which was first presented at 1st Championship Branch Prediction Competition. Our paper investigated different mispredict sources in O-GEHL based exit predictor in hyperblock predictors, and proposed two improved strategies: the O-GEHL based exit predictor without chooser and the O-GEHL based exit predictor employing binary O-GEHL prediction. Performance evaluation results showed that: the proposal without chooser outperformed previously published one by 0.7% with the hardware resource ranging from 16KB to 1MB; the proposal employing 8 binary O-GEHL predictor improved the performance by 3% with the largest hardware resource in this paper (1MB); the proposal employing 4 binary O-GEHL predictor for the first 4 exits averagely improved the performance by 2% with the hardware resource ranging from 16KB to 1MB.
A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy (2021)

Our study provides a proteomic atlas of the healthy and injured arterial wall that can be used to define novel factors for therapeutic targeting. We present TRPC6 as an actionable target to prevent neointima formation secondary to vascular injury and stent implantation.
Effect of (—)-Hydroxycitrate on Fatty Acid Synthesis by Rat Liver in Vivo (1971)

Incorporation of 3H from 3H2O was used to measure the rate of fatty acid synthesis in rat liver. (—)-Hydroxycitrate strongly inhibits fatty acid synthesis in vivo.
Efficacy and Safety of Ledipasvir/Sofosbuvir for the Treatment of Chronic Hepatitis C in Persons With Sickle Cell Disease (2017)

Patients with sickle cell disease are at high risk for chronic hepatitis C infection. Prior treatment has been limited due to the use of ribavirin causing hemolytic anemia and interferon causing cytopenias. We demonstrate the safety and efficacy of fixed-dose combination ledipasvir and sofosbuvir for 12 weeks in this population.
Stabilization/Solidification of Petroleum-Contaminated Soils with Asphalt Emulsions (1999)

This paper describes a research study that was conducted to evaluate the design parameters for asphalt pavements and the mechanical properties of cold mix asphalt concrete (CMA) with petroleum-contaminated soils (PCSs). In this research, several commercially available asphalt emulsions were used to make the CMA. Test results showed that the best emulsion type was cationic slow setting (CSS-1h). In a screening test, CSS-1h produced a CMA of high stability and durability values; therefore, it was used to solidify and stabilize six PCSs. Marshall stability tests indicated that the CMA made with PCSs was strong enough to be used in low volume roads (between 500 and 1,400 lb Marshall stability). The wet/dry durability and freeze/thaw durability of the CMA with PCSs showed durability values that were comparable to those of a regular CMA without PCSs. The CMA with PCSs had hydraulic conductivity values comparable to those of asphalt concrete. There was no leaching of U.S. Environment Protection Agency priority pollutants from CMA mixes. Based on the test data, it was concluded that asphalt emulsions could stabilize and solidify PCSs to produce construction material. The unit cost values showed that it is also a cost-effective recycling process. A user manual is provided for the commercial implementation of the process. Based on its simplicity, cost of production, and end use as a construction material, the CMA technology for PCSs surpasses all other treatment, storage, and disposal methods for petroleum-contaminated soils.
Pulse-frequency-modulated high-frequency-carrier diffractive elements for pattern projection (1994)

An efficient two-stage algorithm is presented for the synthesis of high-frequency-carrier diffractive elements. First, an on-axis phase-only stripe-geometry element with an unconstrained profile along each stripe is designed by an iterative Fourier transform algorithm. In the second stage, a steep linear phase term is added, and the profile is hard-clipped along each stripe. The result is a binary, pulse-frequency-modulated element suitable, e.g. , for a resonance-domain realization, which permits the elimination of the twin image. Experimental results are provided by direct-write electron-beam lithography and optical lithography, using both fully and partially coherent illumination.
A Chance Calculus for Play-Based Exploration (2017)

This paper presents a rules-based calculus for prospect chance estimation. A key idea is that estimates are based on a combined categorization of our knowledge level (DATA dimension) and our model of the geological context (MODEL dimension). We call it a chance calculus that combines data and judgement with simple rules. Earlier work (Milkov, 2014) is extended by using two-level chance rules that distinguish between shared play chance estimates and conditional prospect chance estimates as well as by a second separate step that handles seismic anomalies. The chance calculus provides estimates that are consistent and cover all chance factors and all conventional exploration situations. Explicit MODEL categorization not only provides a transparent, unambiguous basis for the chance estimates, but also eliminates double risking between shared and conditional chance estimates.
Note On Insect Visitors To Corallorhiza Innata And Some Other Orchids In The Forth District (1917)

(1917). Note On Insect Visitors To Corallorhiza Innata And Some Other Orchids In The Forth District. Transactions of the Botanical Society of Edinburgh: Vol. 27, No. 2, pp. 136-138.
Study on the galactose oxidase biosensor based on SiO<inf>2</inf> sol-gel (2011)

A galactose oxidase biosensor is prepared based on the Prussian Blue(PB) modified electrode combined with SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> sol-gel immobilization method in a "sandwich configuration". Its electrochemical characterization and related experiment condition have been studied in detail. The optimin detection potential is -100mV at pH 7.0, 25 °C.Under selected condition the sensor offered high sensitivity of 0.127μA (mmol·L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , a linear range of 0-18 mmol·L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and a detection limit of 0.03mmol·L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ,The response time is 10s. Both stability and selectivity of the biosensor are ideal.
Recent Strategies for Retrieving Chemical Structure Information on the Web (1998)

Abstract The ability to search and display chemical structures is as important as to search journal articles by authors or by titles. This paper discusses various structural searching methods available on the web. Some databases such as the Brookhaven Protein Database use keyword searching which does not provide the desired substructure search capabilities. Others like CS CheinFinder and MDL's Chemscape use graphical plug-in programs. Although plug-in programs provide more capabilities, users first have to obtain a copy of the programs. Due to this limitation, Tripos's WebSketch and ACD Interactive Lab adopt a different approach. Using JAVA applets, users create and display a structure query of the molecule on the web page without using other software. In short, chemical substructure searching has entered a new era. This new technique will likely extend itself to other electronic publications.
Modern Reduction Methods (2008)

REDUCTIONS OF CARBONYLES Hydrogenation Transfer-Hydrogenation Metal Hydrides Hydroboration Hydrosilylation Enzymatic REDUCTIONS OF ALKENES Hydrogenation Hydroboration Hydroalumination Hydrosilylation Organocatalysis REDUCTIONS OF IMINES Hydrogenation Transfer-Hydrogenation Hydroboration Hydrosilylation Organocatalysis Bronsted Lewis Base REDUCTIONS OF ALKYNES Hydrogenation Hydroboration Hydrosilylation Hydroalumination REDUCTIVE AMINATIONS Organocatalysis Boranes REDUCTIVE CROSS COUPLINGS Imines and Aldehydes REDUCTIVE HECK COUPLINGS REDUCTIVE COUPLINGS Beta-lactams NA-NAPHTHALENE KINETIC RESOLUTIONS HYDROGENOLYSIS
Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis (2023)

LOY is positively associated with nonmucinous EOC. Differences between estimated and expected model coefficients for LOY components suggest factors beyond ovulation underlie the associations between LOY components and EOC in general and for non-HGSOC.
A novel immunohistochemical method to estimate cell‐cycle phase distribution in archival tissue: implications for the prediction of outcome in colorectal cancer (2003)

An immunohistochemical method for assessing cell-cycle phase distribution in colorectal resection specimens would enable phase data to be incorporated into diagnostic algorithms for the estimation of prognosis and response to adjuvant chemotherapy in colorectal cancer. In contrast to flow cytometry, an immunohistochemical method would also allow the phase distribution to be examined within morphologically heterogeneous regions of neoplasms. Paraffin sections of normal colon (n = 25), colonic adenoma (n = 15), and colonic adenocarcinoma (n = 30) were analysed by immunohistochemistry using antibodies against markers of cell-cycle entry, Mcm-2 and Ki67, and putative markers of the cell-cycle phase, cyclins D1 and E (putative markers of G1 phase), cyclin A (S phase), cytoplasmic cyclin B1 (G2 phase), and phosphohistone H3 (M phase). The phase specificity of each marker was assessed by examining the degree of co-expression of adjacent phase markers using double-antibody fluorescence confocal microscopy and by comparison with flow cytometric analysis performed on adjacent tissue sections. The S-phase specificity of detectable cyclin A was also assessed in combination with in situ DNA replication using fluorescence confocal microscopy. All cells expressing phase markers co-expressed Mcm-2. Adjacent phase markers were not significantly co-expressed, confirming the relative specificity of these markers in tissue sections of colon. Cell-cycle phase distribution, calculated by immunohistochemistry, compared well with phase analyses obtained by flow cytometry. No cells expressed cyclin A in the absence of active DNA replication. The S-phase labelling index, as defined by detectable cyclin A expression, showed a positive correlation with the Mcm-2 labelling index and increased in the progression from normal colon to adenocarcinoma. In conclusion, a combination of these cell-cycle phase markers can be used to calculate the distribution of cells throughout each phase of the cell cycle in colorectal tissue sections. Detectable cyclin A can be used as a surrogate marker of S phase and may be of value in predicting prognosis and response to adjuvant therapy.
Rational design of substrate analogues targeted to selectively inhibit replication-specific DNA polymerases. (1986)

The authors' approach to the design of DNA polymerase-specific inhibitors, an approach based on the mechanism of action of 6-(p-hydroxyphenylazo)uracil, has been to disguise nucleic acid bases to mimic the purine substrates dGTP and dATP. Specifically, the strategy has been to synthesize bases with substituents that endow them with the capacity: to seek and react with unique features of the active site of a polymerase; and to form H bonds with complementary template pyrimidines apposing the active site. This strategy has yielded a series of novel, enzyme-specific dATP and dGTP analogues which are non-polymerizable and which inhibit their target polymerase by sequestering it to a complementary pyrimidine residue in primer:template. The work has involved primarily two replication-specific polymerases, B. subtilis DNA polymerase III (pol III) and mammalian DNA polymerase alpha (pol alpha). The initial design exploited the pyrimidine nucleus and produced inhibitors with Ki values in the micromolar range. Principles established with the pyrimidine derivatives have led to the development of bona fide purine nucleotide analogues which act as DNA polymerase inhibitors of high selectivity and unprecedented potency. For example, BuPdGTP, the 2'-deoxyribonucleoside 5'-triphosphate of N2-(p-n-butylphenyl)guanine (BuPG), lacks discernible activity against mammalian polymerases beta and gamma, whereas it inhibits mammalian pol alpha with a Ki of less than 10 nanomolar. Currently, the authors are exploiting BuPdGTP, BuPdGDP, and similar butylanilino derivatives of dATP to probe the active site of pol alpha and to develop other N2-substituted analogues which can bind selectively to the substrate sites of other important polymerases and nucleotide binding proteins.
A Nonlinear Attitude Observer Based on Active Vision and Inertial Measurements (2011)

This paper presents an experimentally evaluated solution to the problem of estimating the attitude of a rigid body using rate gyros and a pan-tilt camera. A nonlinear attitude observer combines angular velocity measurements obtained from rate gyros with images of a planar scene provided by the camera. By directly exploiting the sensor information, a stabilizing feedback law is introduced, and exponential convergence to the origin of the estimation errors is shown. Additionally, an active-vision system is proposed that relies on an image-based exponentially input-to-state-stable control law for the pan and tilt angular rates of the camera to keep the features in the image plane. Using recent results in geometric numerical integration, a multirate implementation of the observer is proposed, which exploits the complementary bandwidth of the sensors. Practical considerations, such as the lens-distortion compensation and the computation of suitable observer feedback gains, are considered. Experimental results obtained with a high-accuracy motion rate table demonstrate the high level of performance attained by the proposed solution.
Development and Evaluation of a Live Attenuated Egg-Based Camelpox Vaccine (2021)

Camelpox is an infectious viral disease of camels reported in all the camel-breeding areas of Africa, north of the equator, the Middle East and Asia. It causes huge economic loss to the camel industry. We developed a live camelpox virus vaccine candidate using an attenuated strain and evaluated its safety, immunogenicity and protective efficacy in camels. The attenuated virus strain was generated from the camelpox wild-type strain M-96 by 40 consecutive passages on the chorioallantoic membrane of 11-day-old embryonated chicken eggs, henceforth called KM-40 strain. Reversion to virulence of the KM-40 strain was evaluated in camels by three serial passages, confirmed its inability to revert to virulence and its overdose administration was also found safe. Studies of immunogenicity and protective efficacy of the candidate vaccine KM-40 strain in camels was carried out using the dose of 5 x 10<sup>4.0</sup> EID<sub>50</sub>. Our data showed complete protection against the challenge infection using the virulent wild-type camelpox virus strain M-96 (dose of 10<sup>5.0</sup> EID<sub>50</sub>) which was evaluated at 1, 3, 6 and 12 months post vaccination. In summary, our candidate live attenuated egg-based camelpox vaccine strain KM-40 was found safe, protective, and thus has the potential to use safely in field conditions.
SdrF, a Staphylococcus epidermidis Surface Protein, Binds Type I Collagen (2007)

Staphylococcus epidermidis is the leading cause of device-related infections. These infections require an initial colonization step in which S. epidermidis adheres to the implanted material. This process is usually mediated by specific bacterial surface proteins and host factors coating the foreign device. Some of these surface proteins belong to the serine-aspartate repeat (Sdr) family, which includes adhesins from Staphyloccus aureus and S. epidermidis. Using a heterologous expression system in Lactococcus lactis to overcome possible staphylococcal adherence redundancy we observed that one of these Sdr proteins, SdrF, mediates binding to type I collagen when present on the lactococcal cell surface. We used lactococcal recombinant strains, a protein-protein interaction assay and Western ligand blot analysis to demonstrate that this process occurs via the B domain of SdrF and both the alpha1 and alpha2 chains of type I collagen. It was also found that a single B domain repeat of S. epidermidis 9491 retains the capacity to bind to type I collagen. We demonstrated that the putative ligand binding N-terminal A domain does not bind to collagen which suggests that SdrF might be a multiligand adhesin. Antibodies directed against the B domain significantly reduce in vitro adherence of S. epidermidis to immobilized collagen.