gebhart/patrepeval huggingface dataset:
Chinese Hairy Brush: A physically-based model for calligraphy (2009)

This paper presents a physically-based virtual Chinese hairy brush model which can be used as adigital tool for learning or creating Chinese calligraphy orChinese painting. The whole framework of the proposedmethod comprises three components, i.e., brush geometrymodel, brush dynamic model and ink model. Instead ofsimulating the brush with bristles, our geometry modeluses points to simulate the whole brush bundle, which candrastically decrease the complexity inherent in the conventional bristle-level approach. The dynamic model describesthe behavior of the real brush's deformation in terms ofthe interaction of the external and internal forces with thevirtual writing paper, and a spring network is derived tocalculate the physical deflection of brush according to theforce exerted on it. The ink model describes the process ofink depositing in which brush geometry model is instancedand transformed into a real screen presentation.
Electrical and metallurgical characteristics of PtxSi1−x/n-GaAs contacts (1987)

Forward current–voltage characteristics of carrier transport at PtxSi1−x/n-GaAs interfaces have been measured in the as-deposited state and after annealing at 500 °C for 4 h. The single phase alloy Pt0.5Si0.5 shows Schottky diode characteristics with the barrier height (φb) 0.70 eV and the ideality factor (η) 1.17. Rutherford backscattering of He4 ions and Auger depth profiles for Pt, Si, Ga, and As reveal that the Pt0.5Si0.5/n-GaAs interface remains metallurgically inert even after the heat treatment. The observed metallurgical nonreactivity is reflected in the diode characteristics of the annealed samples which show negligible changes in φb and η. The silicon rich PtxSi1−x (x&amp;lt;0.5) alloy compositions show near-Ohmic transport in the as-deposited and annealed states. These films are also metallurgically inert on annealing.
Trihaloacetic acids: an investigation of steric and inductive ligand effects on the synthesis of [Mn12O12(O2CCX3)16(H2O)4] single-molecule magnets (2005)

The preparation of three new single-molecule magnets (SMM), [Mn12O12(O2CCX3)16(H2O)4], where X = F, Cl or Br, was attempted. Reaction of [Mn12O12(O2CtBu)16(H2O)4] (1) with the carboxylic acid CF3COOH yielded small black needle-like crystals of complex [Mn12O12(O2CCF3)16(H2O)4]·2.5H2O (2). Frequency-dependent out-of-phase ac signals in the range 4–7 K were observed, which indicates that complex 2 functions as an SMM. On the contrary, the use of the bulkier trihaloacetic acids CCl3COOH and CBr3COOH is shown to disrupt the formation of the [Mn12O12(O2CR)16(H2O)4] single-molecule magnets, giving rise to the formation of low nuclearity clusters. On the basis of these results and by comparison with the stability of previously described Mn12 complexes, an interplay of steric and inductive effects is proposed as the critical factor in determining the thermal stability of these complexes.
Optimisation des propriétés anisotropes d'échantillons massifs supraconducteurs Bi2223 texturés par frittage-forgeage (2003)

The high-Tc superconducting (Bi,Pb)2Sr2Ca2Cu3O10+x (Bi2223) oxide has been synthesised by a sol-gel route. The calcination and sintering conditions have been optimized in order to synthesise a nearly pure Bi2223 phase, around 94%. The resulting powder has been sinter-forged under air into highly textured discs by optimising the processing conditions. Bars cut from these discs exhibit reproducible transport critical current densities (Jc) having values around 10000 A/cm2 (0 T, 77 K) which are similar to the maximum ones present in the literature. A new way of synthesis, consisting in texturing pellets composed of the Bi2212 phase and secondary phases, was undertaken. The control of the particles size (⊕<63µm) and of the sinter-forging parameters (845°C/100h) allowed to attain Jc around 12500 A/cm2. Ball milling of the sol-gel powder is crucial for increasing its reactivity and in the same time the ratio of Bi2223 phase after sintering-forging. The great quantity of liquid phase produced during texturation allowed the improvement of texture quality via a better alignment of the grains and thus led to strongly increase the critical current densities (20000 A/cm2). In addition, the stacking of several discs was not only shown to be a possible and fast process, but also to produce a massive ceramic with critical current densities almost identical to that obtained on only one disc. The combined analysis (texture/structure/microstructure) treated via the program MAUD presents a great effectiveness to characterize our samples. Thanks to neutron diffraction, a direct relation between the Bi2223 phase content, the cell parameters, the crystallites size , the density of maximum distribution and the transport critical current density was established.
50-50 multivariate analysis of variance for collinear responses (2002)

Summary. Classical multivariate analysis-of-variance tests perform poorly in cases with several highly correlated responses and the tests collapse when the number of responses exceeds the number of observations. This paper presents a new method which handles this problem. The dimensionality of the data is reduced by using principal component decompositions and the final tests are still based on the classical test statistics and their distributions. The methodology is illustrated with an example from the production of sausages with responses from near infra-red reflectance spectroscopy. A closely related method for testing relationships in uniresponse regression with collinear explanatory variables is also presented. The new test, which is called the 50–50 F-test, uses the first k components to calculate SS MODEL. The next d components are not involved in SS ERROR and they are called buffer components.
Highly efficient, practical approach to natural taxol (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly efficient, practical approach to natural taxolJean Noel. Denis, Andrew E. Greene, Daniel. Guenard, Francoise. Gueritte-Voegelein, Lydie. Mangatal, and Pierre. PotierCite this: J. Am. Chem. Soc. 1988, 110, 17, 5917–5919Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00225a063https://doi.org/10.1021/ja00225a063research-articleACS PublicationsRequest reuse permissionsArticle Views3046Altmetric-Citations469LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Double‐blind, randomized phase 3 trial of low‐dose 13‐cis retinoic acid in the prevention of second primaries in head and neck cancer: Long‐term follow‐up of a trial of the Eastern Cooperative Oncology Group‐ACRIN Cancer Research Group (C0590) (2017)

Treatment with low-dose 13-CRA for 2 years did not decrease the incidence of SPT; subset analysis indicates a potential survival advantage among patients who are women and never/former smokers. More targeted interventions based on clinical risk factors and molecular characterization of tumors may yield greater success in future prevention trials. Cancer 2017;123:4653-4662. © 2017 American Cancer Society.
Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate. (1985)

Treatment of isolated hepatocytes with the tumor-promoting agent, 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) produced a time- and dose-dependent, non-competitive inhibition of alpha 1-adrenergic responses, including the activation of phosphorylase, increase in Ca2+ efflux, increase in free cytosolic Ca2+, and release of myo-inositol-1,4,5-P3. The actions of [8-arginine] vasopressin (AVP) on liver cells were also inhibited by PMA, but the inhibition could be overcome by high AVP concentrations. No significant inhibition of beta-adrenergic and glucagon-mediated activation of phosphorylase was induced by PMA and no inhibitory or synergistic effects of PMA were observed on the dose-dependent activation of phosphorylase by the Ca2+ ionophore A23187. In radioligand binding studies, PMA did not directly interfere with [3H]prazosin specific binding, the displacement of [3H]prazosin by (-)-norepinephrine nor with [3H]AVP specific binding to purified liver plasma membranes. Plasma membranes prepared from livers perfused with PMA exhibited a 30-44% reduction in [3H]prazosin binding capacity. Under identical conditions [3H]AVP binding was unchanged. The alpha 1-receptors remaining in membranes from PMA-treated livers had equivalent affinities for [3H]prazosin and (-)-norepinephrine, and were unaffected in terms of coupling to guanine nucleotide-regulating proteins as indicated by the ability of guanosine 5'-(beta, gamma-imido)triphosphate to promote the conversion of the remaining alpha 1-receptors into a low affinity state. These data indicate that tumor promoters are potent antagonists of alpha 1-adrenergic and vasopressin (low dose) responses in liver. It is proposed that PMA acting via protein kinase C (which presumably mediates the action of PMA) exerts its inhibitory action on alpha 1-adrenergic responses at the alpha 1-adrenergic receptor itself and also at a site close to or before myo-inositol-1,4,5-P3 release.
Concurrent SSA form in the presence of mutual exclusion (2002)

Most current compiler analysis techniques are unable to cope with the semantics introduced by explicit parallel and synchronization constructs in parallel programs. In this paper we propose new analysis and optimization techniques for compiling explicitly parallel programs that use mutual exclusion synchronization. We introduce the CSSAME form, an extension of the Concurrent Static Single Assignment (CSSA) form that incorporates mutual exclusion into a data flow framework for explicitly parallel programs. We show how this analysis can improve the effectiveness of constant propagation in a parallel program. We also modify a dead-code elimination algorithm to work on explicitly parallel programs. Finally, we introduce lock independent code motion, a new optimization technique that attempts to minimize the size of critical sections in the program.
143 Heat Stress Mitigation Strategies for Boars and Impact of Most Effective on Sperm Parameters. (2018)

Thermal conditions were measured with temperature and humidity sensors (Onset® Hobologgers) in eleven commercial boar studs in five states. Large White x Landrace F1 boars (n=12; Choice Genetics®) were exposed to representative summertime conditions (heat stress, HS; 22 to 25°C) and heat wave conditions (HW; 25 to 32°C) utilizing the Brody Environmental Chambers at the University of Missouri. Neck and testicular drippers (1 gph) with and without forced air (100 cfm) were applied directly to each boar in a Latin square design with three day periods. Nooyen’s® Cool Sow Floor was tested with each boar under HS and HW using a switchback design with a seven day period. Shoulder, ear, scrotal, and rectal temperatures as well as respiration rate at 0700 and 1500 hours were recorded. Boars were implanted surgically with two temperature sensing telemetry devices (Anipill® Temperature Implant): one implanted between the peritoneum and the body wall (core temperature); the other sutured between the testicular tunics (testicular temperature). Boar temperatures were analyzed using PROC MIXED (SAS 9.4). Least squares means were calculated after nonsignificant effects and interactions were removed in a stepwise fashion. The treatment most effective at creating the largest difference between treatment and control was the combination of drippers and fans on both scrotum and neck. Subsequently, this was applied to six boars (TRT) and six received no cooling (control) with all under HS. The implanted device data showed that the treatment boars had significantly lower testicular temperatures than control (32.90°C vs. 33.90°C, p-value = 0.002). However, core temperature did not vary significantly between boars. After two months boars were slaughtered and sperm collected from the epididymides of each boar. Sperm analysis was conducted using an image based flow cytometer measuring DNA fragmentation (TUNEL) ubiquitination (anti-ubiquitin/UBB antibody), surface glycosylation (lectin LCA), and acrosomal abnormalities (lectin PNA). Critical thresholds for each trait were identified as percentage of sample: TUNEL less than 5%, UBB less than 30%, LCA less than 10% and PNA greater than 50%. Cooling was effective at mitigating the impact of heat stress on sperm quality parameters, with a higher proportion of TRT boars meeting sperm quality targets (n TRT vs n CONTROL, 6 vs. 4 for TUNEL, 4 vs. 2 UBB, 4 vs. 2 LCA, and 4 vs. 1 for PNA respectively). Even under relatively mild thermal stress representative of commercial boar studs in the US, opportunities to improve sperm quality through cooling exist.
Chiral Separation of Lorazepam on Ovomucoid-Bonded Columns: Peak Coalescence Due to Racemization (1993)

Abstract Racemic lorazepam (LZ) was separated on an ovomucoid (OVM)-bonded column by changing the column temperature. Chromatographic peak coalescence, appearing as a plateau between the resolved peaks, was observed above column temperatures of 15°C. Each LZ enantiomer was isolated on another chiral column using a non-aqueous eluent. Racemization of each LZ enantiomer in two different solutions and peak coalescence on these chiral columns were investigated. These results revealed that the peak coalescence should be due to racemization of LZ on the OVM-bonded column. By reducing the column temperature to 7°C, the enantiomeric composition of LZ before chromatography could be determined on the OVM-bonded column.
ChemInform Abstract: ORGANOSILICON COMPOUNDS WITH FUNCTIONAL GROUPS PROXIMATE TO SILICON. PART 15. ,N‐TRIORGANOSILYL MIGRATIONS IN THE REARRANGEMENTS OF SILYL‐SUBSTITUT D ORGANOLITHIUM COMPOUNDS (1982)

Abstract Am Beispiel der über die entsprechenden Anionen verlaufenden Umlagerungen der Organosilane (I), (VI) und (VIII) zu den Verbindungen (IV), (VII) bzw. (IX) werden 1,2‐, 1,3‐ und 1,4‐Silylwanderungen untersucht.
SMAD SIGNALING IN MESENCHYMAL AND CHONDROPROGENITOR CELLS (2003)

Taken together, our data suggest that uncommitted mesenchymal cells do not have the cellular competence to respond to the rate-limiting chondroinductive factor BMP. However, in chondroprogenitor cells, BMP stimulates differentiation through mechanisms mediated by Smad1 or Smad5 in combination with Smad4.
Identification and C-Terminal Characterization of Proteins from Two-Dimensional Polyacrylamide Gels by a Combination of Isotopic Labeling and Nanoelectrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2000)

We propose a novel method for the identification and C-terminal characterization of proteins separated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Proteins were digested in a gel in a buffer solution containing 50% 18O-labeled water, and mixtures of 18O/16O-labeled peptides were analyzed by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). This method was evaluated using horse skeletal muscle myoglobin as the model protein in SDS gel. The high resolution of FT-ICR MS minimized the overlapping of peptide peaks and facilitated identification of the C-terminal peptide, which was done by observing the undisrupted isotope peak pattern. As well, with its low ppm-level high mass accuracy, it can rapidly and reliably identify the in-gel-separated protein and determine its C-terminal by peptide mass fingerprinting alone. Therefore, this method should be applicable to routine and high-throughput proteome studies. Here, the method was applied to the analysis of rat liver proteins separated by 2D-PAGE. The C-termini of eight proteins were successfully identified out of 10 randomly picked Coomassie brilliant blue-stained spots. The feasibility and limitations of this approach are reported in this paper.
[Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood]. (1990)

The clinical efficacy and tolerability of gastroprotected ferritin were assessed in children affected by iron deficiency and/or sideropenic anemia. Forty-seven children with iron-deficiency and/or sideropenic anemia were included in the study and were treated with gastroprotected ferritin at a dose of 4-5 mg/kg/day per os for 4 months. Only 33 children correctly completed the entire treatment cycle, achieving a marked improvement of blood parameters (increased Hb, accompanied by higher levels of sideremia and in particular ferritin, with a contemporary decrease in erythrocytic protoporphyrin and transferrinemia) and clinical symptoms, especially pallor, anorexia, debility, somnolence, hyperactivity, disturbed sleep and excessive sweating. Of the remaining 14 children, 9 failed to present for the planned control after the 4 months of therapy, 3 abandoned therapy due to difficulties of assumption and 2 because of intolerance phenomena, such as nausea and diarrhoea. In conclusion, gastroprotected proteoferrin is efficacious and well tolerated in the treatment of iron deficiency in children.
College libraries in Shimoga district: A survey (2005)

The study evaluates the present situation of College Libraries in Shimoga District (Karnataka). A survey of 30-degree colleges is conducted through a questionnaire. The analysis of the collected data covers the organizational set-up of the library, library facilities, library resources, and services and physical facilities etc. Concludes that the present situation of the college libraries in Shimoga District do not meet the prescribed norms.
Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2 (2020)

Ionotropic glutamate receptors are ligand-gated ion channels governing neurotransmission in the central nervous system. Three major types of antagonists are known for the AMPA-type receptor GluA2: competitive, noncompetitive (i.e., negative allosteric modulators; NAMs) used for treatment of epilepsy, and uncompetitive antagonists. We here report a 4.65 Å resolution X-ray structure of GluA2, revealing that four molecules of the competitive antagonist ZK200775 and four molecules of the NAM GYKI53655 are capable of binding at the same time. Using negative stain electron microscopy, we show that GYKI53655 alone or ZK200775/GYKI53655 in combination predominantly results in compact receptor forms. The agonist AMPA provides a mixed population of compact and bulgy shapes of GluA2 not impacted by addition of GYKI53655. Taken together, this suggests that the two different mechanisms of antagonism that lead to channel closure are independent and that the distribution between bulgy and compact receptors primarily depends on the ligand bound in the glutamate binding site. DATABASE: The atomic coordinates and structure factors from the crystal structure determination have been deposited in the Protein Data Bank under accession code https://doi.org/10.2210/pdb6RUQ/pdb. The electron microscopy 3D reconstruction volumes have been deposited in EMDB (EMD-4875: Apo; EMD-4920: ZK200775/GYKI53655; EMD-4921: AMPA compact; EMD-4922: AMPA/GYKI53655 bulgy; EMD-4923: GYKI53655; EMD-4924: AMPA bulgy; EMD-4925: AMPA/GYKI53655 compact).
INSULIN-LIKE GROWTH FACTOR-I AMELIORATES DELAYED KIDNEY GRAFT FUNCTION AND THE ACUTE NEPHROTOXIC EFFECTS OF CYCLOSPORINE1 (1997)

In evaluating this study it should be recognized that the animal models studied, although widely used, differ from the human condition. However, IGF-I and des(1-3)IGF-I exhibit properties that strongly suggest their value in preventing clinical DGF, and they deserve further studies.
Mobilization of the gentamicin resistance gene in Enterococcus faecalis (1990)

Enterococcus faecalis plasmid pBEM10 (a conjugative plasmid encoding beta-lactamase production and gentamicin resistance [Gmr]) was made transfer deficient by using Tn917. Relocation of the Gmr determinant into two sites on pCF10 was observed. Restriction analysis revealed insertion of a common 2.5-kilobase-pair HindIII and a 3.9-kilobase-pair HaeIII fragment encoding Gmr, suggesting that this determinant resides on a transposon similar to Tn4001.
Optimized Pseudotyping Conditions for the SARS-COV-2 Spike Glycoprotein (2020)

The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) Spike glycoprotein is solely responsible for binding to the host cell receptor and facilitating fusion between the viral and host membranes. The ability to generate viral particles pseudotyped with SARS-COV-2 Spike is useful for many types of studies, such as characterization of neutralizing antibodies or development of fusion-inhibiting small molecules. Here, we characterized the use of a codon-optimized SARS-COV-2 Spike glycoprotein for the generation of pseudotyped HIV-1, murine leukemia virus (MLV), and vesicular stomatitis virus (VSV) particles. The full-length Spike protein functioned inefficiently with all three systems but was enhanced over 10-fold by deleting the last 19 amino acids of the cytoplasmic tail. Infection of 293FT target cells was possible only if the cells were engineered to stably express the human angiotensin-converting enzyme 2 (ACE2) receptor, but stably introducing an additional copy of this receptor did not further enhance susceptibility. Stable introduction of the Spike-activating protease TMPRSS2 further enhanced susceptibility to infection by 5- to 10-fold. Replacement of the signal peptide of the Spike protein with an optimal signal peptide did not enhance or reduce infectious particle production. However, modifications D614G and R682Q further enhanced infectious particle production. With all enhancing elements combined, the titer of pseudotyped HIV-1 particles reached almost 10<sup>6</sup> infectious particles/ml. Finally, HIV-1 particles pseudotyped with SARS-COV-2 Spike were successfully used to detect neutralizing antibodies in plasma from coronavirus disease 2019 (COVID-19) patients, but not in plasma from uninfected individuals.<b>IMPORTANCE</b> In work with pathogenic viruses, it is useful to have rapid quantitative tests for viral infectivity that can be performed without strict biocontainment restrictions. A common way of accomplishing this is to generate viral pseudoparticles that contain the surface glycoprotein from the pathogenic virus incorporated into a replication-defective viral particle that contains a sensitive reporter system. These pseudoparticles enter cells using the glycoprotein from the pathogenic virus, leading to a readout for infection. Conditions that block entry of the pathogenic virus, such as neutralizing antibodies, will also block entry of the viral pseudoparticles. However, viral glycoproteins often are not readily suited for generating pseudoparticles. Here, we describe a series of modifications that result in the production of relatively high-titer SARS-COV-2 pseudoparticles that are suitable for the detection of neutralizing antibodies from COVID-19 patients.