gebhart/patrepeval huggingface dataset:
Poly(ε-caprolactone)/Poly(ethylene glycol)/Poly(ε-caprolactone) Nanoparticles: Preparation, Characterization, and Application in Doxorubicin Delivery (2009)

Biodegradable poly(epsilon-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems. In this article, monodisperse poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) (PCL/PEG/PCL, PCEC) nanoparticles, approximately 40 nm, were prepared by solvent extraction method using acetone as the organic solvent. These PCL/PEG/PCL nanoparticles did not induce hemolysis in vitro and did not show toxicity in vitro or in vivo. The prepared PCL/PEG/PCL nanoparticles were employed to load doxorubicin by a pH-induced self-assembly method. In vitro release study indicated that doxorubicin release from nanoparticles at pH 5.5 was faster than that at pH 7.0. The encapsulation of doxorubicin in PCL/PEG/PCL nanoparticles enhanced the cytotoxicity of doxorubicin on a C-26 cell line in vitro. Meanwhile, compared with free doxorubicin, doxorubicin in nanoparticles could more efficiently treat mice bearing subcutaneous C-26 tumors. The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy.
Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease (2023)

<b>Introduction:</b> Alzheimer's Disease (AD) patients exhibit signs of motor dysfunction, including gait, locomotion, and balance deficits. Changes in motor function often precede other symptoms of AD as well as correlate with increased severity and mortality. Despite the frequent occurrence of motor dysfunction in AD patients, little is known about the mechanisms by which this behavior is altered. <b>Methods and Results:</b> In the present study, we investigated the relationship between cerebrovascular impairment and motor dysfunction in a mouse model of AD (Tg6799). We found an age-dependent increase of extravasated fibrinogen deposits in the cortex and striatum of AD mice. Interestingly, there was significantly decreased cerebrovascular density in the striatum of the 15-month-old as compared to 7-month-old AD mice. We also found significant demyelination and axonal damage in the striatum of aged AD mice. We analyzed striatum-related motor function and anxiety levels of AD mice at both ages and found that aged AD mice exhibited significant impairment of motor function but not in the younger AD mice. <b>Discussion:</b> Our finding suggests an enticing correlation between extravasated fibrinogen, cerebrovascular damage of the striatum, and motor dysfunction in an AD mouse model, suggesting a possible mechanism underlying motor dysfunction in AD.
Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription (2023)

Supplementary Figures 6-9 from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Factors Influencing Variability in Groundwater Monitoring Data Sets (2011)

“Random” variability in groundwater monitoring data sets reduces the ability to identify long‐term concentration trends. This, in turn, increases the time and cost required to evaluate the effectiveness of natural attenuation and other groundwater remedies. To better understand the factors influencing variability in groundwater monitoring results, we have analyzed three large groundwater monitoring data sets. For the three data sets, the long‐term trend in contaminant concentration in each well accounted for an average of 30% to 40% of the overall variation in contaminant concentration. Understanding the causes of the remaining variability would support the development of improved groundwater monitoring methods. All three data sets show large differences in the temporal monitoring records between individual wells (e.g., coefficient of variation for monitoring results from individual wells ranges from 0.08 to 4.6) indicating that well and aquifer factors are more important contributors to variability than sample collection and analysis factors. However, the depth to groundwater ( R 2 = 0.020) and distance between water level and screened interval ( R 2 = 0.049) accounted for only a portion of the differences in variability between wells and other aquifer characteristics evaluated and were not correlated with the observed variability in monitoring results. Unidentified factors were apparently much more important contributors to variability than these factors. The monitoring data sets exhibited two distinct timescales for variability: Time‐independent variability that was apparent even when wells were re‐sampled within a few days and a long‐term variability likely associated with the long‐term concentration trend. The observation of time‐independent variability suggests that frequent monitoring of contaminated monitoring wells serves primarily to characterize sources of variability unrelated to the long‐term trend of primary interest.
Deep CNN Denoiser and Multi-layer Neighbor Component Embedding for Face Hallucination (2018)

Most of the current face hallucination methods, whether they are shallow learning-based or deep learning-based, all try to learn a relationship model between Low-Resolution (LR) and High-Resolution (HR) spaces with the help of a training set. They mainly focus on modeling image prior through either model-based optimization or discriminative inference learning. However, when the input LR face is tiny, the learned prior knowledge is no longer effective and their performance will drop sharply. To solve this problem, in this paper we propose a general face hallucination method that can integrate model-based optimization and discriminative inference. In particular, to exploit the model based prior, the Deep Convolutional Neural Networks (CNN) denoiser prior is plugged into the super-resolution optimization model with the aid of image-adaptive Laplacian regularization. Additionally, we further develop a high-frequency details compensation method by dividing the face image to facial components and performing face hallucination in a multi-layer neighbor embedding manner. Experiments demonstrate that the proposed method can achieve promising super-resolution results for tiny input LR faces.
The Octapeptidic End of the C-Terminal Tail of Histone H2A Is Cleaved Off in Cells Exposed to Carcinogenic Nickel(II) (2003)

We have demonstrated previously that Ni(II) binds to the C-terminal -TESHHKAKGK motif of isolated bovine histone H2A. At physiological pH, the bound Ni(II) assists in hydrolysis of the E-S peptide bond in this motif that results in a cleavage of the terminal octapeptide SHHKAKGK off the histone's C-tail. To test if the hydrolysis could also occur in living cells, we cultured CHO (Chinese hamster ovary), NRK-52 (rat renal tubular epithelium), and HPL1D (human lung epithelium) cells with 0.1-1 mM Ni(II) for 3-7 days. As found by gel electrophoresis, Western blotting, and liquid chromatography/mass spectrometry, histones extracted from the cells contained a new fraction of histone H2A lacking the terminal octapeptide (q-H2A). The abundance of q-H2A increased with Ni(II) concentration and exposure time. It can be anticipated that the truncation of histone H2A may alter chromatin structure and affect gene expression. The present results provide evidence for novel mechanisms of epigenetic effects of Ni(II) that may be involved in nickel toxicity and carcinogenesis.
HD 83443c: A Highly Eccentric Giant Planet on a 22 yr Orbit (2022)

Abstract We report the discovery of a highly eccentric long-period Jovian planet orbiting the hot-Jupiter host HD 83443. By combining radial velocity data from four instruments (AAT/UCLES, Keck/HIRES, HARPS, Minerva-Australis) spanning more than two decades, we find evidence for a planet with m sin <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>i</mml:mi> <mml:mo>=</mml:mo> <mml:msubsup> <mml:mrow> <mml:mn>1.35</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>0.06</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>0.07</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> M J , moving on an orbit with a = 8.0 ± 0.8 au and eccentricity e = 0.76 ± 0.05. We combine our radial velocity analysis with Gaia eDR3 /Hipparcos proper motion anomalies and derive a dynamical mass of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msubsup> <mml:mrow> <mml:mn>1.5</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>0.2</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>0.5</mml:mn> </mml:mrow> </mml:msubsup> <mml:msub> <mml:mrow> <mml:mi>M</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>Jup</mml:mi> </mml:mrow> </mml:msub> </mml:math> . We perform a detailed dynamical simulation that reveals locations of stability within the system that may harbor additional planets, including stable regions within the habitable zone of the host star. HD 83443 is a rare example of a system hosting a hot Jupiter and an exterior planetary companion. The high eccentricity of HD 83443c suggests that a scattering event may have sent the hot Jupiter to its close orbit while leaving the outer planet on a wide and eccentric path.
Professionalism and Communication in the Intensive Care Unit (2008)

The Family Conference Objective Structured Clinical Exam is a reliable exam with high content validity. It seems unique in the literature for assessing surgical trainees' ability to discuss "bad news" with family members in intensive care.
Custom purpose regular expression processor architecture for network processing (2012)

In this paper we introduce the architecture and system platform of a new regular expression processor for next generation security platforms for content awareness and network security processing. The paper first outlines the feature requirements of state-of-the-art network and security systems, then presents the proposed content processing system and processor architecture.
Deep Neural Network Based Multiple Targets DOA Estimation for Millimeter-Wave Radar (2019)

Direction of arrival (DOA) estimation plays an important role in Multi-Input and Multi-Output (MIMO) radar signal processing. Traditional methods, such as discrete Fourier transform (DFT) and multiple signal classification (MUSIC), were proposed for DOA estimation in array radar system. However, the disadvantage of traditional methods are low resolution and limitation of radar freedom under many targets situation. In this paper, a deep neural network (DNN) is proposed applying to a real mono-static millimeter wave MIMO radar system. The model performance are evaluated on test dataset after the model converged. Simulation result confirms that our DNN based DOA estimation algorithm is effective under various criteria including signal success detected ratio, root mean square error (RMSE) and area under the curve (AUC). Different signal resolution results verifies the effectiveness of our algorithm.
Oxidation of Dodecanoate Intercalated Iron(II)–Iron(III) Layered Double Hydroxide to Form 2D Iron(III) (Hydr)oxide Layers (2013)

Abstract A planar trioctahedral iron(II)–iron(III) hydroxide (green rust, GR) intercalated with dodecanoate (GR C12 ) has been oxidized by dioxygen to produce the corresponding planar iron(III) (hydr)oxide. The formulae of GR C12 and the final iron(III) product (oxGR C12 ) were determined to be Fe II 2.00 Fe III 1.00 (OH) 5.31 (C 12 H 23 O 2 ) 0.66 (SO 4 ) 0.51 and Fe III 3 O 2.18 (OH) 3.13 (C 12 H 23 O 2 ) 0.56 (SO 4 ) 0.47 , respectively. oxGR C12 has the same planar layer structure as GR C12 , as revealed by identical powder X‐ray diffraction patterns. The electrostatic interactions between the interlayer dodecanoate (C12) anions and the iron hydroxide planar layer were preserved during the oxidation, as shown by FTIR spectroscopy. The high positive charge in the hydroxide layer produced by the oxidation of iron(II) to iron(III) is partially compensated by the deprotonation of hydroxy groups, as shown by X‐ray photoelectron spectroscopy. The Mössbauer quadrupole splitting of the iron(III) doublet increased on oxidation of GR C12 , which has been attributed to the distortion of the octahedral sites caused by deprotonation and changes in the coordination site geometry. oxGR C12 is stable in air for more than 2 years. The van der Waals interactions between the alkyl chains of the intercalated dodecanoate anions play a crucial role in stabilizing the structure and hindering the collapse of the iron(II)–iron(III) (hydr)oxide structure during oxidation. This is the first report describing the formation of a stable planar layered octahedral iron(III) (hydr)oxide. oxGR C12 shows promise as a sorbent and host for hydrophobic reagents, and as a possible source of single planar layers of iron(III) (hydr)oxide.
Natural Convection Reduction in a Composite Air/Porous Annular Region With Horizontal Orientation (2008)

This paper deals with a numerical investigation on natural convection heat transfer in a long horizontal annular region formed with a heated inner cylinder and a cooled outer cylinder. Identifying the annular region geometrically by its radius ratio, it is divided into two subregions: a thicker outer subregion is filled with a porous material saturated by air, whereas a thinner inner subregion is clear. Based on the general Darcy–Brinkman–Forchheimer model for flow in porous media, numerical calculations with the control volume method produce the velocity and temperature fields of the air motion in the two subregions. The baseline case corresponds to an annular region of same dimensions, but filled completely with a porous material saturated by air. Upon articulating the physical properties of a porous material with the clear gap size, the analyst will be able to tune those conditions that are conducive to heat transfer reduction across the concentric two-cylinder configuration. The outcome of this paper is equivalent to the determination of superior thermal insulation performance using lesser porous material. In other words, this paper boils down to beneficial energy conservation together with money savings in the purchase of the thermal insulation.
Tractable Model for Rate in Self-Backhauled Millimeter Wave Cellular Networks (2014)

Millimeter wave (mmW) cellular systems will require high gain directional antennas and dense base station (BS) deployments to overcome high near field path loss and poor diffraction. As a desirable side effect, high gain antennas provide interference isolation, providing an opportunity to incorporate self-backhauling--BSs backhauling among themselves in a mesh architecture without significant loss in throughput--to enable the requisite large BS densities. The use of directional antennas and resource sharing between access and backhaul links leads to coverage and rate trends that differ significantly from conventional microwave ($μ$W) cellular systems. In this paper, we propose a general and tractable mmW cellular model capturing these key trends and characterize the associated rate distribution. The developed model and analysis is validated using actual building locations from dense urban settings and empirically-derived path loss models. The analysis shows that in sharp contrast to the interference limited nature of $μ$W cellular networks, the spectral efficiency of mmW networks (besides total rate) also increases with BS density particularly at the cell edge. Increasing the system bandwidth, although boosting median and peak rates, does not significantly influence the cell edge rate. With self-backhauling, different combinations of the wired backhaul fraction (i.e. the faction of BSs with a wired connection) and BS density are shown to guarantee the same median rate (QoS).
Electrochemical CO2 Reduction to Formic Acid at Low Overpotential and with High Faradaic Efficiency on Carbon-Supported Bimetallic Pd–Pt Nanoparticles (2015)

The electrochemical reduction of CO2 has attracted significant interest recently, as it is a possible reaction for the storage of renewable energy. Here, we report on the synthesis of PdxPt(100–x)/C nanoparticles and their electrocatalytic properties for the reduction of CO2 to formic acid, compared with their activity for the reverse oxidation of formic acid to CO2. We find that PdxPt(100–x)/C nanoparticles have a very low onset potential for the reduction of CO2 to formic acid of ca. 0 V vs RHE, which approaches the theoretical equilibrium potential of 0.02 V vs RHE for this reaction. Furthermore, the Pd70Pt30/C catalyst shows a faradaic efficiency of 88% toward formic acid after 1 h of electrolysis at −0.4 V vs RHE with an average current density of ∼5 mA/cm2. Therefore, this catalyst shows a competing or even better faradaic efficiency toward formic acid compared to recently reported catalysts, at a substantially lower overpotential, while avoiding a strong deactivation that was observed with previously reported Pd-based catalysts.
Transcranial AC Pulsed Applications of Weak Electromagnetic Fields Reduces Freezing and Falling in Progressive Supranuclear Palsy: A Case Report (1998)

Freezing is a common and disabling symptom in patients with Parkinsonism. It affects most commonly the gait in the form of start hesitation and sudden immobility often resulting in falling. A higher incidence of freezing occurs in patients with progressive supranuclear palsy (PSP) which is characterized clinically by a constellation of symptoms including supranuclear ophthalmoplegia, postural instability, axial rigidity, dysarthria, Parkinsonism, and pseudobulbar palsy. Pharmacologic therapy of PSP is currently disappointing and the disease progresses relentlessly to a fatal outcome within the first decade after onset. This report concerns a 67 year old woman with a diagnosis of PSP in whom freezing and frequent falling were the most disabling symptoms of the disease at the time of presentation. Both symptoms, which were rated 4 on the Unified Parkinson Rating Scale (UPRS) which grades Parkinsonian symptoms and signs from 0 to 4, with 0 being normal and 4 being severe symptoms, were resistant to treatment with dopaminergic drugs such as levodopa, amantadine, selegiline and pergolide mesylate as well as with the potent and highly selective noradrenergic reuptake inhibitor nortriptyline. Weekly transcranial applications of AC pulsed electromagnetic fields (EMFs) of picotesla flux density was associated with approximately 50% reduction in the frequency of freezing and about 80-90% reduction in frequency of falling after a 6 months follow-up period. At this point freezing was rated 2 while falling received a score of 1 on the UPRS. In addition, this treatment was associated with an improvement in Parkinsonian and pseudobulbar symptoms with the difference between the pre-and post EMF treatment across 13 measures being highly significant (p < .005; Sign test). These results suggest that transcranial administration AC pulsed EMFs in the picotesla flux density is efficacious in the treatment of PSP.
Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma (2022)

Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in several cancers, including those of the hepatobiliary tract. However, the role of HH signaling in intrahepatic CCA (iCCA) has not been completely elucidated. In this study, we addressed the function of the main transducer Smoothened (SMO) and the transcription factors (TFs) GLI1 and GLI2 in iCCA. In addition, we evaluated the potential benefits of the combined inhibition of SMO and the DNA damage kinase WEE1. Transcriptomic analysis of 152 human iCCA samples showed increased expression of GLI1, GLI2, and Patched 1 (PTCH1) in tumor tissues compared with nontumor tissues. Genetic silencing of SMO, GLI1, and GLI2 inhibited the growth, survival, invasiveness, and self-renewal of iCCA cells. Pharmacologic inhibition of SMO reduced iCCA growth and viability in vitro, by inducing double-strand break DNA damage, leading to mitotic arrest and apoptotic cell death. Importantly, SMO inhibition resulted in the activation of the G2-M checkpoint and DNA damage kinase WEE1, increasing the vulnerability to WEE1 inhibition. Hence, the combination of MRT-92 with the WEE1 inhibitor AZD-1775 showed increased antitumor activity in vitro and in iCCA xenografts compared with single treatments. These data indicate that combined inhibition of SMO and WEE1 reduces tumor burden and may represent a strategy for the clinical development of novel therapeutic approaches in iCCA.
The clinical significance of large cells in bone marrow in patients with chronic lymphocytic leukemia (2004)

Patients with CLL who had bone marrow that contained > 7% large cells and who had beta(2)-M levels > 5 mg/L had a disease that was similar to RS, and the combination of large cells and beta(2)-M can be used as a surrogate marker for RS.
Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose. (1992)

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine rodent carcinogen that is found at the ppb level in cooked meat. Most laboratory studies are at 10(4)-10(7)-fold greater concentrations than actual ingested human doses. We report the first study of the bioavailability and fate of this heterocyclic amine at a human dietary equivalent dose using the high sensitivity offered by accelerator mass spectrometry. [2-14C]PhIP was administered to C57BL/6 male mice (41 ng/kg) by gavage. Tissues and excreta were collected over the subsequent 96 h. One hundred % of the administered dose was excreted in urine (90%) and feces (10%) over the length of the study. Absorption of the radiocarbon-tagged PhIP from the gastrointestinal tract was rapid, with radiocarbon levels peaking in the whole blood and urine within 1 h of exposure. Fecal 14C levels peaked at 12 h. Tissue levels peaked by 3 h with the highest concentrations of radiolabel in the intestine, stomach, and liver, followed by the kidney, pancreas, lung, and spleen. Low levels of 14C from PhIP (0.01-0.04% of the administered dose) could be detected in the tissues 48-96 h after exposure, possibly due to covalent binding to protein or DNA. The calculated half-life of PhIP at this dose was 1.14 h. This study is the first example of how accelerator mass spectrometry can be used to gather biological information about carcinogenic compounds at environmental levels of exposure.
Optimisation des chambres réverbérantes en basse fréquence pour la réalisation de tests CEM (2014)

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