gebhart/patrepeval huggingface dataset:
Synthesis and reactions of tetranitroethylene (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactions of tetranitroethyleneKurt Baum and Dongjaw TzengCite this: J. Org. Chem. 1985, 50, 15, 2736–2739Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://doi.org/10.1021/jo00215a028RIGHTS & PERMISSIONSArticle Views416Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (545 KB) Get e-Alerts Get e-Alerts
Up‐regulation of kinin B1 receptor in the lung of streptozotocin‐diabetic rat: autoradiographic and functional evidence (2003)

The function and autoradiographic binding expression of kinin B 1 receptors were evaluated in the lungs of Streptozotocin (STZ)‐diabetic rats. The intrapleural injection (i.pl.) of des‐Arg 9 ‐bradykinin (des‐Arg 9 ‐BK) (50 and 100 nmol per site), a selective B 1 receptor agonist, increased time‐dependently the mononuclear and neutrophil cells influx in the pleural cavity of rats treated with STZ (65 mg kg −1 , i.p., 4 days earlier). This effect was significantly less in control rats. The influx of mononuclear and polymorphonuclear neutrophil cells induced by des‐Arg 9 ‐BK was significantly inhibited by two B 1 receptor antagonists (des‐Arg 10 ‐Hoe140 or R‐715, 100 nmol per site, 5 min earlier), but not by two B 2 receptor antagonists (Hoe140, 10 nmol or NPC 18884, 100 nmol per site, 5 min earlier). However, Hoe140 prevented the higher basal leukocyte influx seen in STZ‐diabetic rats. Leukocyte infiltration induced by des‐Arg 9 ‐BK in STZ‐diabetic rats was significantly reduced after treatment with insulin (2 U per day, s.c. over 4 days) or with an anti‐PMN antibody (0.1 ml of a 1 : 20 dilution, i.pl. 5 min earlier). Specific B 1 receptor binding sites were seen in lung sections from both control and STZ‐diabetic rats, yet the density of labelling was much greater in diabetic rats and particularly after intrapleural injection of des‐Arg 9 ‐BK. Treatment with insulin or with the anti‐PMN antibody markedly reduced B 1 receptor binding sites occurring after the injection of des‐Arg 9 ‐BK in STZ‐diabetic rats. Data suggest that the B 1 receptor is up‐regulated in the lungs of STZ‐diabetic rats, and its activation increases leukocyte infiltration into the pleural cavity. The overexpression of B 1 receptors seems to depend on neutrophils influx and appears to be associated with hyperglycaemia. British Journal of Pharmacology (2003) 138 , 13–22. doi: 10.1038/sj.bjp.0704999
The Aging of lignin rich papers upon exposure to light : its quantification and prediction (1999)

A program was undertaken at the Forest Products Laboratory in conjunction with the American Society for Testing and Materials (ASTM) to develop guidelines for a credible accelerated photoaging protocol for printing and writing papers. In support of this, indepth studies of photodegredation were undertaken in sufficient detail to establish the validity of the protocol. Photoaging was carried out in two different environments. The first was intended to simulate natural aging conditions with exposure to artificial and daylight illumination. The second environment provided higher photon flux levels in older to accelerate photoaging. our studies included monitoring the changes in physical and chemical properties that result from the aging process. They also included spectral and chemical characterization of the species that are photosensitive, as well as their chemical transformations. The results and implications of this multiyear effort will be discussed.
45.3: Invited Paper: High Performance Nanocrystalline ZnOxNy for Imaging and Display Applications (2015)

We present versatile ZnO x N y applicable to a wide range of imaging/display devices. A well‐optimized ZnOxNy material exhibits high mobility exceeding 100 cm 2 /Vs, bandgap of 1.3 eV and nanocrystalline microstructure with multiphase. Accordingly, the performance of ZnO x N y ‐based device can be adjustable to meet the requisite of future electronic/photonic device elements.
Aufbau der Corticoid‐Seitenkette aus 17α‐(Halogenethinyl)‐17β‐(nitrooxy)androstenen (1987)

Abstract Die 17α‐(Bromethinyl)‐ und 17α‐(Chlorethinyl)‐17β‐(nitrooxy)‐androsten‐Derivate 2c–f setzen sich in Ameisensäure/ N ‐Methyl‐2‐pyrroliden bei Raumtemperatur mit Silbersalzen zu den 21‐Halogen‐17α‐(formyloxy)‐20‐ketopregnanen 3a–d um, aus denen über die 17α‐Hydroxy‐Verbindungen 3a–h die 21‐Acetoxy‐17α‐hydroxy‐20‐ketone 3i und 3j erhalten werden. – Während die zu 2c analogen 17α ‐(Bromethinyl)‐17β‐benzoate 2k und 2l mit Silbersalzen nicht reagieren, lassen sich die 17α‐(Bromethinyl)‐17β‐trihalogenacetate 2m und 2n bei erhöhter Temperatur in das 21‐Brom‐17α‐(formyloxy)‐20‐keton 3a überführen. Nebenprodukt der Reaktionen 2c→3a und 2m, n→3a ist das Δ 13 ‐Steroid 4 .
ATIM-49 (LTBK-01). AMG 596, A NOVEL ANTI-EGFRVIII BISPECIFIC T CELL ENGAGER (BITE®) MOLECULE FOR THE TREATMENT OF GLIOBLASTOMA (GBM): PLANNED INTERIM ANALYSIS IN RECURRENT GBM (RGBM) (2019)

Abstract OBJECTIVES The class III variant of the epidermal growth factor receptor (EGFRvIII) represents the most common EGFR mutation in GBM. AMG 596 is a bispecific T cell engager (BiTE®) molecule designed to engage a patient’s own CD3-positive T cells to EGFRvIII-positive tumor antigens. This is the first clinical data readout for AMG 596. METHODS This phase 1, first-in-human, open-label, sequential dose-escalation/expansion study evaluates continuous intravenous AMG 596 in patients with EGFRvIII-positive GBM or malignant glioma in recurrent (Group 1) or newly diagnosed in maintenance treatment (Group 2) settings. Eligible patients: adults with EGFRvIII-positive GBM or malignant glioma; ≤2 mg/day dexamethasone, ECOG performance status ≤1; life expectancy ≥3 months; and acceptable renal, hematological, and hepatic function. The primary objective evaluates safety and tolerability. Additional assessments include objective response rate per modified Response Assessment in Neuro-Oncology (RANO) Criteria. RESULTS As of June 2019, 15 rGBM patients (Group 1) were enrolled; 14 patients received ≥1 dose AMG 596. 14/15 (93.3%) patients were evaluable at time of analysis (safety analysis set). Median age was 54.5 years (range, 44–68); 50% were male. Seven patients discontinued for progressive disease (PD). AEs occurred in all patients and were serious in 7/14 (50%). None resulted in discontinuation; two (14.3%) fatal AEs were related to PD. Headache and depressed consciousness (both n=2, 14.3%) were the most common grade ≥3 treatment emergent AEs. In patients with sufficient follow-up to assess response (n=8), 1 (12.5%) achieved partial response, 2 (25%) had stable disease, 4 (50%) had PD at initial scan, and 1 (12.5%) discontinued treatment for PD. Semi-quantitative EGFRvIII expression analysis revealed a median H-score of 115 (range, 8–280). CONCLUSION This interim analysis suggests a first indication that AMG 596 may be well-tolerated and offer anti-tumor activity in patients with rGBM. Enrollment is ongoing and additional data will be presented. NCT03296696.
Generation of Families of Construct Variants Using Golden Gate Shuffling (2011)

Current standard cloning methods based on the use of restriction enzymes and ligase are very versatile, but are not well suited for high-throughput cloning projects or for assembly of many DNA fragments from several parental plasmids in a single step. We have previously reported the development of an efficient cloning method based on the use of type IIs restriction enzymes and restriction-ligation. Such method allows seamless assembly of multiple fragments from several parental plasmids with high efficiency, and also allows performing DNA shuffling if fragments prepared from several homologous genes are assembled together in a single restriction-ligation. Such protocol, called Golden Gate shuffling, requires performing the following steps: (1) sequences from several homologous genes are aligned, and recombination sites defined on conserved sequences; (2) modules defined by the position of these recombination sites are amplified by PCR with primers designed to equip them with flanking BsaI sites; (3) the amplified fragments are cloned as intermediate constructs and sequenced; and (4) finally, the intermediate modules are assembled together in a compatible recipient vector in a one-pot restriction-ligation. Depending on the needs of the user, and because of the high cloning efficiency, the resulting constructs can either be screened and analyzed individually, or, if required in larger numbers, directly used in functional screens to detect improved protein variants.
Synthesis and application of novel phenylboronate affinity materials based on organic polymer particles for selective trapping of glycoproteins (2009)

We report on synthesis concepts for the fabrication of various novel phenylboronate affinity materials based on polymethacrylate epoxy beads (Fractogel EMD Epoxy (M) 40-90 microm) and the testing of these functionalized polymer particles for selective trapping of a glycoprotein from a standard mixture containing a glycosylated and a nonglycosylated protein. Two inherently different approaches for the functionalization of the bare beads with boronate groups have been elucidated. In the first, the epoxy residues of the polymer particles were converted into reactive thiol groups which were subsequently used as anchor moieties for the immobilization of 4-vinylphenylboronic acid by radical addition or radical polymerization reaction. Three different ways for the generation of sulfhydryl groups have been examined leading to materials with distinct linker chemistries. In the second and more straightforward approach, the epoxy groups were reacted with 4-mercaptophenylboronic acid. The novel materials were thoroughly characterized by (i) quantitation of the sulfur content by elemental analysis, (ii) reactive sulfhydryls were determined in a photospectrometric assay, (iii) boron content was measured by inductively coupled plasma-atomic emission spectrometry, and (iv) the amount of reactive boronate groups was evaluated in a fast binding assay employing adenosine as test compound. A maximum concentration of 1.2 mmol boronate groups per gram dry beads could be achieved by the presented synthesis routes. Employing the novel phenylboronate affinity materials in capture and release experiments in the batch mode, a standard glycoprotein, viz. transferrin (Tf) from human serum was separated from a nonglycosylated protein, BSA. A commercial boronate affinity material based on 3-aminophenylboronic acid modified agarose gel was employed as reference material and was found to perform significantly worse compared to the herein presented novel polymethacrylate particles.
Demethylation of dimethylsulfoniopropionate to 3-mercaptopropionate by an aerobic marine bacterium (1994)

A bacterium, strain BIS-6, that grew aerobically on dimethylsulfoniopropionate (DMSP) was isolated from an intertidal mud sample. Strain BIS-6 quantitatively demethylated DMSP and 3-methiolpropionate to 3-mercaptopropionate. Strain BIS-6 was a versatile methylotroph growing on the osmolytes DMSP and glycine betaine and their methylated degradation products (dimethyl glycine, sarcosine, methylamines, and dimethyl sulfide.
Kinetics of the thermal conversion of potassium salts of benzenedicarboxylic and -tricarboxylic acids to terephthalic acid (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the thermal conversion of potassium salts of benzenedicarboxylic and -tricarboxylic acids to terephthalic acidVithal V. S. Revankar and L. K. DoraiswamyCite this: Ind. Eng. Chem. Res. 1992, 31, 3, 781–786Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ie00003a021https://doi.org/10.1021/ie00003a021research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Translation of in Vitro Inhibition by Marine Natural Products of the C4 Acid Cycle Enzyme Pyruvate Pi Dikinase to in Vivo C4 Plant Tissue Death (2005)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionTranslation of in Vitro Inhibition by Marine Natural Products of the C4 Acid Cycle Enzyme Pyruvate Pi Dikinase to in Vivo C4 Plant Tissue DeathDianne S. Haines, James N. Burnell, Jason R. Doyle, Lyndon E. Llewellyn, Cherie A. Motti, and Dianne M. TapiolasCite this: J. Agric. Food Chem. 2005, 53, 24, 9638Publication Date (Web):November 5, 2005Publication History Published online5 November 2005Published inissue 1 November 2005https://doi.org/10.1021/jf058165kCopyright © 2005 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views198Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (15 KB) Get e-Alerts Get e-Alerts
Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension (2009)

Nifedipine efficiently reduces BP for the entire 24 h and to a significantly larger extent after bedtime administration. The significant added efficacy on reducing night-time BP, the decrease in the prevalence of a nondipper BP pattern, and the significant decrease in morning BP surge (all relevant markers of cardiovascular morbidity and mortality) of bedtime as compared with morning administration, consistently indicate that nifedipine should preferably be administered at bedtime in patients with essential hypertension.
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis (2018)

Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 which are crucial for B-cell development. Recent studies from our laboratory and others have shown that deletion of Rptor, a unique component of the mTORC1 nutrient-sensing complex, early in the osteoblast lineage development results in defective bone development in mice. In this study, we now demonstrate that mTORC1 signalling in pre-osteoblasts is required for normal B-lymphocyte development in mice. Targeted deletion of Rptor in osterix-expressing pre-osteoblasts (Rptor<sub>ob</sub><sup>-/-</sup>) leads to a significant reduction in the number of B-cells in the bone marrow, peripheral blood and spleen at 4 and 12 weeks of age. Rptor<sub>ob</sub><sup>-/-</sup> mice also exhibit a significant reduction in pre-B and immature B-cells in the BM, indicative of a block in B-cell development from the pro-B to pre-B cell stage. Circulating levels of IL-7 and CXCL12 are also significantly reduced in Rptor<sub>ob</sub><sup>-/-</sup> mice. Importantly, whilst Rptor-deficient osteoblasts are unable to support HSC differentiation to B-cells in co-culture, this can be rescued by the addition of exogenous IL-7 and CXCL12. Collectively, these findings demonstrate that mTORC1 plays an important role in extrinsic osteoblastic regulation of B-cell development.
Physical properties of Lu1−xYbxNi2B2C (2006)

The Lu1−x Yb x Ni2B2 system exhibits superconductivity at low Yb concentrations (0≤x≤ 0.1), Kondo behaviour at low and moderate Yb concentrations (0≤x≤ 0.34), and heavy fermion behaviour with a non-magnetic ground state at high Yb concentrations. In order to characterize the evolution of these phenomena with x, we have performed dc magnetic susceptibility, electrical resistivity, thermoelectric power, and specific heat measurements on single crystals of Lu1−x Yb x Ni2B2 with various values of x between 0 and 1. The enhanced suppression of T c by Yb substitution, compared to other rare earth substitutions, is consistent with the behaviour of superconducting Kondo systems with T K≫T c when T K decreases with increasing x. The electronic specific heat coefficient γ increases from ∼11 mJ/mol K2 for x=0 to ∼530 mJ/mol K2 for x=1. The curve of the reduced specific heat jump ΔC/ΔC 0 versus T c/T c0, where ΔC 0 and T c0 refer to the LuNi2B2C matrix, does not conform to the BCS theory, but is consistent with the magnetic pair breaking theory of Abrikosov and Gor'kov or the theory of Müller-Hartmann and Zittartz for superconductivity in the presence of the Kondo effect for . This is in agreement with the evolution of the upper critical field H c2 with x, where the slope decreases with increasing x.
Ultrathin MoO3 Layers in Composite Metal Electrodes: Improved Optics Allow Highly Efficient Organic Light‐Emitting Diodes (2018)

Abstract Molybdenum trioxide (MoO 3 ) has been investigated as a seeding and energy‐level modification layer for ultrathin metal electrode in organic light‐emitting diodes (OLEDs). However, the optical effect of this interlayer has not been addressed so far. In this article, the influence of the thin MoO 3 layer for bottom emitting OLEDs is thoroughly investigated. It is noted that a thin MoO 3 layer has a substantial impact on the device performance through inducing a synergistic effect of suppressing the nonradiative surface plasmon polariton (SPP) modes and modulating the cavity resonance. In presence of MoO 3 layer, the SPP mode is suppressed from 400 to 520 nm. Moreover, introducing a thin MoO 3 layer reduces the reflectance of the Au/Ag electrode, resulting in a decreased destructive resonance in devices. These combined effects enable to build highly efficient OLEDs, with the external quantum efficiency and luminous efficacy of two‐unit stacked white OLEDs reaching 38.8% and 53.9 lm W −1 at 1000 cd m −2 , when substrate and air modes are extracted. The efficiency is about 1.9 times higher compared to the one without MoO 3 layer. The result provides insights into indium tin oxide free optoelectronic devices, as well as light extraction strategy and color purity manipulations for OLEDs.
On the Interplay of Telomeres, Nevi and the Risk of Melanoma (2012)

The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi, and nevus count combining data from four studies conducted in Italy. In addition, we examined whether telomere length measured in peripheral blood leukocytes is related to the risk of melanoma, dysplastic nevi, number of nevi, or telomere-related SNPs. A total of 796 cases and 770 controls were genotyped for 517 SNPs in 39 telomere-related genes genotyped with a custom-made array. Replication of the top SNPs was conducted in two American populations consisting of 488 subjects from 53 melanoma-prone families and 1,086 cases and 1,024 controls from a case-control study. We estimated odds ratios for associations with SNPs and combined SNP P-values to compute gene region-specific, functional group-specific, and overall P-value using an adaptive rank-truncated product algorithm. In the Mediterranean population, we found suggestive evidence that RECQL4, a gene involved in genome stability, RTEL1, a gene regulating telomere elongation, and TERF2, a gene implicated in the protection of telomeres, were associated with melanoma, the presence of dysplastic nevi and number of nevi, respectively. However, these associations were not found in the American samples, suggesting variable melanoma susceptibility for these genes across populations or chance findings in our discovery sample. Larger studies across different populations are necessary to clarify these associations.
Step caches - a novel approach to concurrent memory access on shared memory MP-SOCs (2005)

In this paper we introduce a novel class of caches, named step caches, that can be used to implement concurrent memory access in shared memory multithreaded multiprocessor systems on chip (MP-SOC) without cache coherency problems. The main difference between ordinary caches and steps caches is that data entered to a step cache is kept valid only until the end of ongoing step of multithreaded execution. We describe the structure and operation of step caches as well as give a performance evaluation of step cache systems with different settings using simple parallel programs on our paramedical MP-SOC framework. According to the evaluation, step caches speed up execution by a factor close to the number of processors in respect to the similar system without step caches and almost achieve the performance of the ideal shared memory systems in plain concurrent access.
Combining Graph-based Dependency Features with Convolutional Neural Network for Answer Triggering (2018)

Answer triggering is the task of selecting the best-suited answer for a given question from a set of candidate answers if exists. In this paper, we present a hybrid deep learning model for answer triggering, which combines several dependency graph based alignment features, namely graph edit distance, graph-based similarity and dependency graph coverage, with dense vector embeddings from a Convolutional Neural Network (CNN). Our experiments on the WikiQA dataset show that such a combination can more accurately trigger a candidate answer compared to the previous state-of-the-art models. Comparative study on WikiQA dataset shows 5.86% absolute F-score improvement at the question level.