gebhart/patrepeval huggingface dataset:
Randomized trial of standard chemotherapy alone or combined with atezolizumab as adjuvant therapy for patients with stage III colon cancer and deficient mismatch repair (ATOMIC, Alliance A021502). (2019)

e15169 Background: In metastatic colorectal cancer with deficient DNA mismatch repair (dMMR), anti-PD-1 antibody monotherapy produced high tumor response rates and extended progression-free survival compared to lack of benefit for cancers with proficient MMR. In an ongoing phase III randomized trial, we will determine if the addition of the anti-PD-L1 antibody, atezolizumab (Genentech), to adjuvant FOLFOX can improve patient disease-free survival (DFS) vs FOLFOX alone in patients with stage III colon cancers with dMMR. By blocking the PD-1/PD-L1 interaction, atezolizumab may activate T cells, thereby, restoring their ability to detect and attack tumor cells. Limited data suggest that FOLFOX may increase intratumoral cytotoxic CD8+ T cells that could serve as ‘immune priming'. Methods: Patients with curatively resected stage III colon carcinomas with evidence of dMMR are randomized to modified FOLFOX6 for 6 months (12 cycles) alone (control arm) or combined with atezolizumab (840 mg IV q2 wk) with continuation of the antibody as monotherapy for an additional 6 months (total duration of 12 months) [experimental arm]. Patients will be stratified by T, N stage and tumor sidedness. Local testing for MMR proteins is allowed. Atezolizumab must begin by/with cycle 2. One cycle of FOLFOX is allowed pre-registration. The targeted accrual goal of 700 patients and 165 disease-free survival (DFS) events will provide 90% power to detect an effect size expressed as hazard ratio of 0.6 for the primary endpoint of DFS at two-sided alpha of 0.05. Interim analyses are planned at 50% and 75% of events. Secondary endpoints include overall survival, treatment tolerability, and quality of life. Results: This study is being conducted by the Alliance for Clinical Trials in Oncology, was approved by NCI CTEP and activated in 09/2017. The study is actively accruing and, as of 02/11/2019, 152 patients are enrolled. We are actively exploring an international collaboration. Conclusions: This is a current clinical trial in progress. Clinical trial information: NCT02912559.
Mixing by a bubbly flow in a Hele-Shaw cell: time-resolved measurements and modelling (2013)

The present work investigates the mixing of a low diffusivity fluorescent dye within a homogeneous swarm of high-Re air bubbles rising in a vertical Hele-Shaw cell filled with water, for gas volume fractions from 1.4 to 5.4%. A given amount of Rhodamine WT is injected at a given location within the bubble swarm during a finite time at the beginning of the experiment. The bubbles motion generates liquid agitation, which causes a specific mixing of the dye. The local dye concentration at a given location is measured by an original Laser Induced Fluorescence (LIF) technique. On one side of the cell, a first optical fibre connected to a laser is used to light up a volume of 0.2 mm³. On the other side of the cell, a second optical fibre collects the emitted light in an observation volume of 7 mm³. Thanks to a spectrophotometer connected to this fibre, the fluoresced light, which intensity is proportional to the dye concentration, is separated from the incident light. This system allows us to record the time evolution of the local dye concentration at a frequency of 250 Hz. Concurrently, the distribution of the bubbles around the measurement volume is imaged with a high speed camera synchronized with the spectrometer. This camera is used to assess the LIF technique in bubbly flow. At a certain distance above the injection point, the dye concentration signal is characterized by rapid and intense fluctuations corresponding to the passages of patches of dye carried by individual bubbles superimposed to a slow global evolution. The global time evolution of the concentration shows two stages. It first increases as the injected dye is transported by the bubbles towards the measurement volume and then decreases as it moves farther. At large time, the global decrease is observed to be exponential, which is incompatible with a Fickian diffusive process but consistent with the transport of the dye by the mean wakes and the wake vortices that are quickly damped out by wall friction. The mixing by the bubble swarm is a convective intermittent process.
Linear and nonlinear optical properties of chalcogenide microstructured optical fibers (2015)

Chalcogenide glasses are known for their large transparency in the mid-infrared and their high linear refractive index (&gt;2). They present also a high non-linear coefficient (n<sub>2</sub>), 100 to 1000 times larger than for silica, depending on the composition. we have developed a casting method to prepare the microstructured chalcogenide preform. This method allows optical losses as low as 0.4 dB/m at 1.55 µm and less than 0.05 dB/m in the mid IR. Various chalcogenide MOFs operating in the IR range has been fabricated in order to associate the high non-linear properties of these glasses and the original MOF properties. For example, small core fibers have been drawn to enhance the non linearities for telecom applications such as signal regeneration and generation of supercontinuum sources. On another hand, in the 3-12 µm window, single mode fibers and exposed core fibers have been realized for Gaussian beams propagation and sensors applications respectively.
A Tunable and Wearable Dual-Band Metamaterial Absorber Based on Polyethylene Terephthalate (PET) Substrate for Sensing Applications (2022)

Advanced wireless communication technology claims miniaturized, reconfigurable, highly efficient, and flexible meta-devices for various applications, including conformal implementation, flexible antennas, wearable sensors, etc. Therefore, bearing these challenges in mind, a dual-band flexible metamaterial absorber (MMA) with frequency-reconfigurable characteristics is developed in this research. The geometry of the proposed MMA comprises a square patch surrounded by a square ring, which is mounted over a copper-backed flexible dielectric substrate. The top surface of the MMA is made of silver nanoparticle ink and a middle polyethylene terephthalate (PET) substrate backed by a copper groundsheet. The proposed MMA shows an absorption rate of above 99% at 24 and 35 GHz. In addition, the absorption features are also studied for different oblique incident angles, and it is found that the proposed MMA remains stable for θ = 10-50°. The frequency tunability characteristics are achieved by stimulating the capacitance of the varactor diode, which connects the inner patch with the outer ring. To justify the robustness and conformability of the presented MMA, the absorption features are also studied by bending the MMA over different radii of an arbitrary cylinder. Moreover, a multiple-reflection interference model is developed to justify the simulated and calculated absorption of the proposed MMA. It is found that the simulated and calculated results are in close agreement with each other. This kind of MMA could be useful for dual-band sensing and filtering operations.
The Titanium Vacuum Chamber for the Zero Gradient Synchrotron (1969)

An all metal, titanium alloy inner vacuum chamber has been built for the Zero Gradient Synchrotron (ZGS). This chamber has high radiation resistance, high mechanical strength, and provides mountings for pole face windings. The upper and lower surfaces of the chamber consist of 0.012" titanium skins which span the 32" aperture along the 54' length of the octant. These skins are reinforced with radial T-shaped ribs 3/8" high to withstand the design loading of 30 torr. The 20 miles of titanium ribs are diffusion bonded to the skins to provide high strength joints without welding. Eddy-current problems are minimized by using an alloy of high electrical resistivity. Pole face windings mounted in holes in the ribs will be used to correct the effects of the residual eddy currents. Many of the new techniques that were developed for aerospace applications were used to produce and test this chamber. These techniques and the results of the tests will be discussed.
The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo (2016)

The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), which are associated with a variety of diseases including tumors, produce various small noncoding RNAs (sncRNAs) such as microRNAs (miRNAs). Like all herpesviruses, they show two stages in their life cycle: lytic replication and latency. During latency, hardly any viral proteins are expressed to avoid recognition by the immune system. Thus, sncRNAs might be exploited since they are less likely to be recognized. Specifically, it has been proposed that sncRNAs might contribute to the maintenance of latency. This has already been shown in vitro, but the respective evidence in vivo is very limited. A natural model system to explore this question in vivo is infection of mice with murine gammaherpesvirus 68 (MHV-68). We used this model to analyze a MHV-68 mutant lacking the expression of all miRNAs. In the absence of the miRNAs, we observed a higher viral genomic load during late latency in the spleens of mice. We propose that this is due to a disturbed regulation of the latent-to-lytic switch, altering the balance between latent and lytic infection. Hence, we provide for the first time evidence that gammaherpesvirus sncRNAs contribute to the maintenance of latency in vivo.
Functional Characterization of a Novel BRCA1-Null Ovarian Cancer Cell Line in Response to Ionizing Radiation (2007)

The breast and ovarian cancer susceptibility gene BRCA1 plays a major role in the DNA damage response pathway. The lack of well-characterized human BRCA1-null cell lines has limited the investigation of BRCA1 function, particularly with regard to its role in ovarian cancer. We propagated a novel BRCA1-null human ovarian cancer cell line UWB1.289 from a tumor of papillary serous histology, the most common form of ovarian carcinoma. UWB1.289 carries a germline BRCA1 mutation within exon 11 and has a deletion of the wild-type allele. UWB1.289 is estrogen and progesterone receptor negative and has an acquired somatic mutation in p53, similar to the commonly used BRCA1-null breast cancer cell line HCC1937. We used ionizing radiation to induce DNA damage in both UWB1.289 and in a stable UWB1.289 line in which wild-type BRCA1 was restored. We examined several responses to DNA damage in these cell lines, including sensitivity to radiation, cell cycle checkpoint function, and changes in gene expression using microarray analysis. We observed that UWB1.289 is sensitive to ionizing radiation and lacks cell cycle checkpoint functions that are a normal part of the DNA damage response. Restoration of wild-type BRCA1 function in these cells partially restores DNA damage responses. Expression array analysis not only supports this partial functional correction but also reveals interesting new information regarding BRCA1-positive regulation of the expression of claudin 6 and other metastasis-associated genes and negative regulation of multiple IFN-inducible genes.
Flash-lamp-triggered high-power thyratron-type switch (1988)

Extremely high cold cathode emission and a plasma current density that is much higher than commercial glow discharge hot cathode switches have been obtained in a flash-triggered hollow cathode thyratron-type switch that operates in a glow mode. The cold cathode emission is higher by several orders of magnitude than emission from thermionic cathodes in high-power hydrogen thyratrons, without arc formation. Peak current &amp;gt;17 kA, dI/dt&amp;gt;3×1011 A/s, and power gain &amp;gt;1400 are observed. The switch has been successfully operated as a thyratron substitute in a commercial XeCl excimer laser. The work demonstrates a new approach to thyratron-type switches, and a wide range of technologically useful physical processes that are poorly understood.
A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors (1990)

With [3H]ketanserin as the radioligand, structure-affinity relationships (SAFIRs) for binding at central 5-HT2 serotonin receptors (rat frontal cortex) were examined for a series of 27 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropane derivatives (2,5-DMAs). The affinity (Ki values) ranged over a span of several orders of magnitude. It appears that the lipophilic character of the 4-position substituent plays a major role in determining the affinity of these agents for 5-HT2 receptors, 2,5-DMAs with polar 4-substituents (e.g. OH, NH2, COOH) display a very low affinity (Ki greater than 25,000 nM) for these receptors, whereas those with lipophilic functions display a significantly higher affinity. The results of these studies prompted us to synthesize and evaluate examples of newer lipophilic derivatives and several of these (e.g. n-hexyl, n-octyl) bind with very high (Ki values = 2.5 and 3 nM, respectively) affinities at central 5-HT2 sites. Although, 2,5-DMAs are generally considered to be 5-HT2 agonists, preliminary studies with isolated rat thoracic aorta suggest that some of the more lipophilic derivatives (e.g. the n-hexyl and n-octyl derivatives) are 5-HT2 antagonists.
DAS 28 for defining remission in rheumatoid arthritis in Indian patients (2006)

To establish DAS 28 and DAS 28-3 scores that best define remission in Indian patients with rheumatoid arthritis (RA). All patients diagnosed with RA visiting AIIMS, New Delhi over a period of 3 months were recruited. Clinical assessment included 28 joint counts for swelling and tenderness, duration of early morning stiffness, patient global assessment of disease activity, fatigue, joint pains and ESR. DAS 28 and DAS 28-3 scores were calculated and receiver operating characteristics curve analysis was performed to define cutoff values utilizing ‘ACR 5/6’ and ‘ACR 4/5’ remission criteria. Subjects included 207 patients (M: 44; F: 163) with mean age of 47.4 ± 12.6 years, median disease duration of 8 [4.12–14] years.‘ACR 5/6’ and ‘ACR 4/5’ criteria for remission were satisfied by 34 (16.42%) and 44 patients (21.25%) patients, respectively. DAS 28 score of 2.94 (sensitivity 84.4%, specificity 85.3%) and DAS 28-3 score of 3.02 (sensitivity 82.1%, specificity 82.4) best defined the ‘ACR 5/6’ remission. Corresponding values using ‘ACR 4/5’ remission were 3.04 (sensitivity 85.9%, specificity 84.1%) for DAS 28 and 3.05 (sensitivity 82.2%, specificity 81.8%) for DAS 28-3. A cutoff value < 3 for both DAS 28 and DAS 28-3 defines remission in RA in Indian patients.
Building blocks of biological networks: a review on major network motif discovery algorithms (2012)

In recent years, there has been a great interest in studying different aspects of complex networks in a range of fields. One important local property of networks is network motifs, recurrent and statistically significant sub-graphs or patterns, which assists researchers in the identification of functional units in the networks. Although network motifs may provide a deep insight into the network's functional abilities, their detection is computationally challenging. Therefore several algorithms have been introduced to resolve this computationally hard problem. These algorithms can be classified under various paradigms such as exact counting methods, sampling methods, pattern growth methods and so on. Here, the authors will give a review on computational aspects of major algorithms and enumerate their related benefits and drawbacks from an algorithmic perspective.
Effects of repeated exposure on acceptance of initially disliked vegetables in 7-month old infants: Individual differences in intake and liking patterns (2007)

International audience
Activity of human monocytes in IgE antibody‐dependent surveillance and killing of ovarian tumor cells (2003)

We have previously shown that a chimeric IgE antibody against the folic acid receptor (MOv18 IgE) inhibits tumor growth in a SCID mouse model of ovarian carcinoma. MOv18 IgE gave greater protection than the corresponding chimeric MOv18 IgG1. We have now confirmed these effects in a nude-mouse model of ovarian carcinoma and have demonstrated for the first time that human monocytes are active in IgE antibody-dependent cell-mediated cytotoxicity. Injection of tumor-bearing mice with PBMC and MOv18 IgE led to infiltration of monocytes into the tumors and prolonged survival of the mice. Incubation of PBMC or purified monocytes and MOv18 IgE with ovarian tumor cells in vitro resulted in tumor cell killing proportional to the expression of unoccupied FcepsilonRI on monocytes.We observed phagocytosis of tumor cells by the monocytes in vitro. Our results suggest that tumor-specific IgE antibodies may be exploited for immunotherapy of cancer.
POCS-Based Iterative Reconstruction Algorithm of Missing Textures (2007)

In this paper, a new framework for texture reconstruction of missing areas, which exist all over the target image, is presented. The framework is based on a projection onto convex sets (POCS) algorithm including a novel constraint. In the proposed method, a nonlinear eigenspace of each cluster obtained by texture classification is applied to the constraint. Furthermore, by monitoring the errors converged by the POCS algorithm, selection of the optimal cluster for the target texture including missing intensities is realized in order to reconstruct it adaptively. Then, iterating the POCS-based procedures, our method renews the nonlinear eigenspaces and the reconstruction image, and outputs the reliable result. This approach provides a solution to the problem in traditional methods of not being able to perform adaptive reconstruction of the target textures due to the missing intensities. Experimental results show subjective and quantitative improvement of the proposed reconstruction technique over previously reported reconstruction techniques.
Iohexol, platelet activation and thrombosis (1998)

Iohexol and 580 or 825 mosmol glucose trigger platelet secretion of beta-TG. This secretion is not associated with enhanced collagen-induced platelet thrombus formation at high arterial shear.
Factors affecting the performance of an ultrastable telescope: turning over all the rocks (2019)

Future observatories capable of detecting Earth-like planets around other stars will have to be large and exquisitely stable, a so-called ultra-stable system (USS). The stability requirements for a USS are orders of magnitude greater stability than current systems. The analysis, design and verification of these systems will require detailed knowledge of all the factors that affect its performance. At performance levels measured in picometers, forces and effects that are negligible for current systems can become important actors. To assure there are no bad actors waiting in the wings to spoil the performance of a future ultra-stable system, a systematic and comprehensive study has been carried out to assess the impact to system performance for many of these small and typically ignored effects. The work presented includes the effects of system self-interactions and system interaction with the environment and the impact of both on the stability of the figure in a spatial and temporal sense.
Effects of inotropic and arrhythmogenic digoxin doses and of digoxin-specific antibody on myocardial monovalent cation transport in the dog. (1979)

The effects of digoxin on monovalent cation active transport were determined in cardiac tissue obtained from dogs given inotropic, toxic, or lethal doses of digoxin. In hemodynamically monitored dogs, active uptake of the K+ analogue Rb+ was determined in vitro in a control myocardial biopsy, and then in serial biopsies from the same dog after the infusion of [3H]digoxin in doses sufficient to cause a sustained positive inotropic effect in the absence of toxicity, and finally after additional doses to induce overt toxicity. Nontoxic digoxin doses producing a mean increase of 20% in left ventricular (LV) dP/dt significantly reduced Rb+ active transport by 25% below control values. At the onset of digoxin-induced arrhythmias, maximal LV dP/dt was 53% above control whereas active Rb+ transport was reduced by 60% below baseline values (P less than 0.001). Control dogs given vehicle alone showed no significant change in contractility or in monovalent cation active transport. In another group of dogs given a lethal dose of digoxin, Rb+ active transport was reduced 59% below control levels at the onset of overt toxicity and was further reduced 80% below control at the time of onset of a fatal rhythm disturbance. When dogs were given high affinity digoxin-specific IgG or Fab fragments at the onset of overt toxicity, toxicity was rapidly reversed, and monovalent cation active transport increased to 51% of control at the time of restoration of sinus rhythm. Twenty-four hours after antibody reversal of arrhythmias, monovalent cation transport values approximated normal control levels. These data provide quantitative estimates of the extent of inhibition of monovalent cation transport by digoxin at inotropic, toxic, and lethal endpoints. Similar degrees of transport inhibition were present at the time of onset of digoxin-induced arrhythmias and at the time or arrhythmia reversal by digoxin-specific antibodies.
Pore Condensation and Critical-Point Shift of a Fluid in Controlled-Pore Glass (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPore Condensation and Critical-Point Shift of a Fluid in Controlled-Pore GlassMatthias Thommes and Gerhard H. FindeneggCite this: Langmuir 1994, 10, 11, 4270–4277Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/la00023a058https://doi.org/10.1021/la00023a058research-articleACS PublicationsRequest reuse permissionsArticle Views838Altmetric-Citations183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Smartphone positioning in multi-floor environments without calibration or added infrastructure (2016)

Indoor positioning for smartphone users has received a lot of attention in recent years. While many solutions have been developed, most rely on a need for pre-deployment of infrastructure or collecting ground truth data to train on. In this paper we see what can be done using existing WiFi-infrastructure and Received Signal Strength from these to smartphones, not using any calibration of the signal environment or manually set WiFi positions. We expand on previous work by using a multi-floor model taking into account dampening between floors, and optimize a target function consisting of least squares residuals, to find positions for WiFis and the smartphone measurement locations simultaneously. Pressure sensors are used to do floor estimation. The method was tested inside two multi-story buildings, with 5 stories each, with median errors of smartphone positions of 12.5m and 16.4m and with WiFi median position errors of 7.16m and 19.4m respectively. Correct floor detection was achieved for 96% of all smartphone positions.