gebhart/patrepeval huggingface dataset:
Pyrroloquinoline Quinone (PQQ) and Quinoprotein Enzymes (2001)

This review summarises the characteristics, identification, and measurement of pyrroloquinoline quinone, the prosthetic group of bacterial quinoprotein dehydrogenases whose structures, mechanisms, and electron transport functions are described in detail. Type I alcohol dehydrogenase includes the "classic" methanol dehydrogenase; its x-ray structure and mechanism are discussed in detail. It is likely that its mechanism involves a direct hydride transfer rather than a mechanism involving a covalent adduct. The x-ray structure of a closely related ethanol dehydrogenase is also described. The type II alcohol dehydrogenase is a soluble quinohaemoprotein, having a C-terminal extension containing haem C, which provides an excellent opportunity for the study of intraprotein electron transfer processes. The type III alcohol dehydrogenase is similar but it has two additional subunits (one of which is a multihaem cytochrome c) bound in an unusual way to the periplasmic membrane. One type of glucose dehydrogenase is a soluble quinoprotein whose role in energy transduction is uncertain. Its x-ray structure (in the presence and absence of substrate) is described together with the detailed mechanism, which also involves a direct hydride transfer. The more widely distributed glucose dehydrogenases are integral membrane proteins, bound to the membrane by transmembrane helices at the N-terminus.
Acute respiratory failure in kidney transplant recipients: a multicenter study (2011)

In kidney transplant recipients, ARF is associated with high mortality and graft loss rates. Increased Pneumocystis and bacterial prophylaxis might improve these outcomes. Early ICU admission might prevent graft loss.
Controlled Release of Food Additives (1988)

A number of situations in food processing, and in processing of related biological systems require control of diffusion of specific components of the system. This is particularly true in the use of functional food additives. A substance in formulated food may be released upon consumption, but prevented from diffusion during the series of operations in food processing: (e.g. flavors, nutrients). Similarly an additive may be released in a specific processing step, but protected in preceeding steps, (e.g. acids, leavening agents, crosslinking agents). In other cases preservatives which are needed in given portion of the food (e.g. surface) are to be prevented from diffusion to other portion (to avoid dilution). A variety of food additives may be utilized in food processing and their typical functions are shown in Table 1. The types of approaches taken in food technology to control diffusion through encapsulation of ingredients are shown in Table 2, and
Le moteur à charge stratifiée, Un moyen de réduction des NOx (2023)

Afin de réduire la quantité d’oxyde d’azote formée dans un moteur à essence, la solution proposée est la combustion stratifiée. Pour cela, le modèle multi zone est utilisé pour l’étude du processus de combustion et la formation de l’oxyde d’azote dans un moteur à allumage commandé. Il commence par l’utilisation de l’approche de Wiebe pour décrire le processus de dégagement de chaleur durant la phase de combustion. L’utilisation d’un schéma d’équilibre chimique pour le système C – H – O – N est nécessaire pour le calculer de la concentration des espèces dans les gaz d’échappement,. Ainsi, les résultats théoriques des deux types de moteurs (à charge homogène et à charge stratifiée) issus de ce modèle sont comparés avec ceux mesurés.
Viral Clearance by Traditional Operations With Significant Knowledge Gaps (Session II): Cation Exchange Chromatography (CEX) and Detergent Inactivation (2014)

At the previous viral clearance symposium, insights into the general mechanism of viral clearance by cation exchange chromatography (CEX) were shared by Amgen and Novartis ([1][1]). Amgen presented data from multiple monoclonal antibody (mAb) products that consistently revealed ≥4 log10 murine
Alteration of Hybridoma Viability and Antibody Secretion in Transfectomas with Inducible Overexpression of Protein Disulfide Isomerase (1995)

Monoclonal antibody (mAb)-secreting transfectomas with dexamethasone inducible expression of the mammalian endoplasmic reticulum foldase and chaperone protein disulfide isomerase (PDI, ERp59) were generated from the murine 9.2.27 hybridoma in order to obtain in vivo evidence of whether alteration of the level of PDI, believed to be involved in immunoglobulin (Ig) assembly, results in alteration of mAb secretion kinetics. Using an RNase refolding assay, the specific activity of endogenous PDI in the 9.2.27 hybridoma was found to be constant during batch growth. An expression vector for glucocorticoid-inducible overexpression of PDI, pMMTVPDI, was constructed from pMAMneo using a rat PDI cDNA. Cell lysates of stable transfectomas contained 2-4-fold higher levels of PDI mRNA and increased levels of PDI protein, detected by immunoblotting, following induction with 0.1 microM dexamethasone. Monoclonal antibody secretion kinetics were evaluated in 12.5 mL shake flasks, a 100 mL spinner, and a 1 L aerated batch reactor. A transfectoma was found with altered mAb secretion kinetics during cell growth following dexamethasone induction of PDI overexpression. Specific mAb secretion rate was not significantly increased following dexamethasone induction; however, hybridoma viability was sustained longer during the stationary phase of cell growth and hence total antibody yield was increased in comparison to the parent 9.2.27 hybridoma.
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis (2020)

20(S)-PPD inhibits endometrial cancer cell proliferation by inducing cell death via a caspase-mediated apoptosis pathway. Therefore, the 20(S)-PPD-like ginsenosides are endowed with ample structural information that could be utilized to develop other ginsenoside-based anticancer agents.
A theoretical and experimental study of magnetostrictive mini-actuators (1994)

The magnetostrictive mini-actuator (MMA), with its unique characteristics such as large strain, high force and high energy density, is potentially a new class of actuator most suitable for distributed actuator applications such as vibration control of smart structures. The authors present a theoretical framework, validated experimentally, to develop an MMA and its feasibility for vibration control. Based on two-dimensional thermal analysis, the general form of thermoelastic mathematical model for characterizing magnetostrictive-based actuators is proposed and experimentally validated. Thermal effects, at other than the initial state, are shown to have a significant effect on attainable strain and force of an MMA. Experimental results show that the MMA has good static and dynamic performance, and is suitable for applications in smart structures.
Tunneling magnetoresistance effect in a few-electron quantum-dot spin valve (2008)

We demonstrate the tunneling magnetoresistance (TMR) effect through a semiconductor quantum dot (QD) with a few electrons in a lateral QD spin-valve device. At one-to-two electron transition, only inverse TMR effect is observed, where the TMR ratio is relatively large compared with the value based on the Julliere model. When the bias window reaches near the charging energy of the QD, the inverse TMR almost disappears. These features can be interpreted in terms of spin transport via the ground state of a two-electron QD.
The effects of inertia on the viscoelastic Dean and Taylor–Couette flow instabilities with application to coating flows (1992)

The effects of inertia on the elastic instabilities in Dean and Taylor–Couette flows are investigated through a linear stability analysis. The critical conditions and the structure of the vortex flow at the onset of these instabilities are presented. The results reveal that the purely elastic Dean flow is destabilized by inertial effects. It is also found that inertia destabilizes elastic Taylor–Couette flow if the rotation of the inner cylinder is the flow driving force, while it stabilizes the flow driven by rotation of the outer cylinder. The mechanism of destabilization or stabilization of these viscoelastic instabilities is investigated through an examination of the disturbance-energy equation. It is shown that Dean flow is destabilized by two separate mechanisms: a purely elastic mechanism discussed previously (i.e., energy production due to the coupling of a perturbation velocity to the polymeric stress gradient in the base state) [see Phys. Fluids A 3, 1691 (1991)] and a purely inertial mechanism discussed by Dean [Proc. R. Soc. London Ser. A 121, 402 (1928)] (i.e., energy production from Reynolds stresses). It is also shown that, when rotation of the inner cylinder drives Taylor–Couette flow, the Reynolds stresses produce energy, and thus are destablizing, while for the flow driven by the rotation of the outer cylinder alone, the Reynolds stresses dissipate energy, thus stabilizing the flow. The elastic forces remain destabilizing in both modes of operation. In a second study, a pressure-driven viscoelastic coating flow over a curved surface is examined. The results demonstrate the existence of a purely elastic stationary instability in the coating flow on a concave wall which is very similar to that which occurs in viscoelastic Dean flow. It is demonstrated that the mechanisms of instability in Dean flow and the coating flow are the same, again through an examination of the disturbance-energy equation.
Robust Fitting of Subdivision Surfaces for Smooth Shape Analysis (2018)

Most shape analysis methods use meshes to discretize the shape and functions on it by piecewise linear functions. Fine meshes are then necessary to represent smooth shapes and compute accurate curvatures or Laplace-Beltrami eigenfunctions at large computational costs. We avoid this bottleneck by representing smooth shapes as subdivision surfaces and using the subdivision scheme to parametrize smooth surface functions with few control parameters. We propose a model to fit a subdivision surface to input samples that, unlike previous methods, can be applied to noisy and partial scans from depth sensors. The task is formulated as an optimization problem with robust data terms and solved with a sequential quadratic program that outperforms the solvers previously used to fit subdivision surfaces to noisy data. Our experiments show that the compression of a subdivision representation does not affect the accuracy of the Laplace-Beltrami operator and allows to compute shape descriptors, geodesics, and shape matchings at a fraction of the computational cost of mesh representations.
Intra Block-DPCM with Layer Separation of Screen Content in VVC (2019)

An intra coding algorithm with layer separation is proposed. This algorithm is designed on top of an adopted tool in VVC, called Block DPCM (BDPCM), and benefits from texture information in a neighborhood to derive intensity levels of background and foreground layers. This information is used to reduce large rate of residual in case of incorrect layer prediction by BDPCM. For this purpose, three inter-layer transition states are defined that are either implicitly or explicitly conveyed to the decoder. Once a transition is signaled, the decoder corrects the prediction value using the derived layer information. Experiments on screen contents show a BD-rate gain of about 10% percent over VVC Test Model (VTM) and 1% over the regular BDPCM, with the cost of computational complexity.
Electronic and Resonance Raman Spectra of the μ-tris(Bipyrazine)ruthenium(II)-Hexaquis{ruthenium(II)EDTA} Supramolecular Complex (1997)

Abstract Resonance Raman and electronic spectra of the μ-tris(bipyrazine)ruthenium(II)-hexaquis{ruthenium(II)EDTA} supramolecular complex are reported in this paper. Excitation in the 457–676 nm range leads to the selective enhancement of the Ru-bipyrazine vibrational peaks according to distinct patterns, supporting the assignment of the absorption bands at 670 and 490 nm as charge-transfer (MLCT) transitions from the [RuIIEDTA] dπ orbitals to the π1∗ and π2∗ LUMO levels of the bipyrazine ligand. A vibronic coupling mechanism involving the two excited states is suggested for the excitation at 490 nm. The occurrence of MLCT transitions in the [Ru(bpz)3]2+ central unity, around 440 nm, is supported by the Raman and fluorescence excitation profiles.
Catalytic Asymmetric Intramolecular Aminopalladation: Improved Palladium(II) Catalysts. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Automatic Tuning of Microwave Silicon Photonic Ring Resonators (2023)

This paper presents an automatically calibrated and tuned microwave silicon photonic ring resonator. Due to process variations, the initial response of the ring resonator is severely distorted. By embedding a tunable coupler (Mach-Zehnder interferometer (MZI)) and a photo-detector (PD)-based monitor within the ring, and developing a proper automatic tuning algorithm, the desired microwave frequency response of the ring with free spectral range (FSR) of 50 GHz is reconstructed and its resonance frequency is tuned. RF measurements show cancellation of10 and 20 GHz signals by tuning the ORR.
Dermatologic Effects and Management of Urine and Feces on Infant and Adult Skin (2014)

The effect of urine and feces on the skin is a contributing factor to the development of incontinent and diaper dermatitis. The objective of this research was to evaluate skin effects of a given urine or fecal sample on the donor child and/or an adult care
Effects of Endocytosis Inhibitory Drugs on Rubella Virus Entry into VeroE6 Cells (2004)

It has been suggested that infectious entry of rubella virus (RV) is conducted by receptor mediated endocytosis. To explore the cellular entry mechanism of RV, inhibitory effects of drugs affecting various endocytic pathways on RV entry into VeroE6 cells were analyzed. Results showed that RV infectious entry into VeroE6 cells is mediated by clathrin-dependent endocytosis and not by caveolae-mediated endocytosis. Moreover, chemical inhibition of macropinocytosis such as treatments of amiloride, actin and microtubule-disrupting drug significantly reduced RV infection. Considering that macropinocytosis is inducible endocytosis by cellular stimulations, clathrin-mediated endocytosis is likely to be a major route of RV infectious entry.
The Use of a Pipeline Embolization Device for Treatment of a Ruptured Dissecting Middle Cerebral Artery M3/M4 Aneurysm: Challenges and Technical Considerations (2022)

Prompt, effective treatment is necessary following aneurysmal subarachnoid hemorrhage to prevent recurrent rupture, which is thought to double mortality. Atypical ruptured aneurysms, such as blister or dissecting pseudoaneurysms, or those that are unusually distal in the middle cerebral artery (MCA) are challenging to treat with either open or endovascular options, though the pipeline embolization device (PED) has shown promise in multiple case series. We present a case of a ruptured dissecting pseudoaneurysm in the distal MCA (distal M3/proximal M4) prefrontal division in an healthy young patient (<60 years) successfully treated with a PED. The PED was chosen both as the only vessel sparing option in the young patient as well as for its potential as a vessel sacrifice tool if the pseudoaneurysm was felt to be incompletely treated, which in this case was not necessary-though would have leveraged the thrombogenicity of the device as a therapeutic advantage.
nm23 in the Primary and Metastatic Sites of Gastric Carcinoma (1999)

Tumor metastasis is the major cause of treatment failure and death in cancer patients. The present study was designed to extrapolate the association of nm23 expression with acquisition of metastatic potential of gastric carcinoma with special reference to the alpha-fetoprotein-producing gastric carcinoma (APGC). The primary tumor with surrounding normal mucosa and metastatic lymph nodes of 30 patients with APGC and 29 randomly selected matched controls of non-AFP gastric carcinoma (NAGC) were immunostained for nm23 and an image analyzer system was used for quantitative evaluation. Overexpression of nm23 was noted in 71% (42/59) of the primary tumors and 18% (10/55) of the metastatic tumors and there was no difference between the APGC and NAGC groups. The overexpression of nm23 in the primary tumors correlated with tumor invasion, metastasis and progression in all cases and similar results were obtained in the APGC and NAGC groups except for the tumor stage which was insignificant in the APGC group. The patient survival was adversely affected by the overexpression of nm23 in the primary sites and downregulation in the metastatic sites in all cases but lost their significance in the multivariate analysis. However, nm23 status did not affect patient survival in the APGC group.
supplementary methods from Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer (2023)

&lt;p&gt;Contain all the supplementary methods linked to this paper&lt;/p&gt;
Impact of Ice Formation in Diesel Fuel on Tier 4 Off-Road Engine Performance with High Efficiency Fuel Filtration (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The winter of 2013-2014 provided an opportunity to operate off-road vehicles in cold weather for extended time as part of a vehicle/tier 4 diesel engine validation program. An unexpected area of study was the performance of high efficiency, on engine, fuel filters during continuous vehicle operation in cold weather. During the program we observed unexpected premature fuel filter plugging as indicated by an increase in pressure drop across the filter while in service. Field and laboratory testing was completed at John Deere and Donaldson to understand the cause of filter plugging.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Although conditions were found where winter fuel additives could cause plugging of high efficiency filters, premature filter plugging occurred even when testing with #1 diesel fuel. This fuel contained no additives and was used at temperatures well above its cloud point. In some cases, laboratory testing of returned plugged filters did not reveal a high pressure drop across the filter and visual examination did not provide additional insight.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper discusses the vehicle/tier 4 engine and filter testing activity that lead us to conclude that ice crystals, formed when initially dissolved water in diesel fuel is exposed to sub-freezing temperatures, can cause temporary plugging of high efficiency fuel filters. Included is information on filter testing, laboratory testing methods, and results along with information about fuel, temperatures, and dissolved water content.&lt;/div&gt;&lt;/div&gt;
Gas‐bearing hydrothermal dolomite prediction using probabilistic neural networks in the Trenton‐Black River Interval, NE Ohio (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003Gas‐bearing hydrothermal dolomite prediction using probabilistic neural networks in the Trenton‐Black River Interval, NE OhioAuthors: David A. MinkenJohn P. CastagnaDavid A. MinkenUniversity of Oklahoma and John P. CastagnaUniversity of Oklahomahttps://doi.org/10.1190/1.1817948 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817948FiguresReferencesRelatedDetailsCited ByAn innovative way of computing reliable density from impedance inversion methodsRitesh Sharma, Satinder Chopra, and Larry Lines17 August 2017Reducing uncertainty in characterization of Vaca Mureta shale with post-stack seismic dataRitesh Kumar Sharma, Satinder Chopra, Luis Vernengo, Eduardo Jorge Trinchero, and Claudio Sylwan19 August 2015Hydrocarbon-bearing dolomite reservoir characterization: A case study from eastern CanadaAmit Kumar Ray, Ritesh Kumar Sharma*, and Satinder Chopra5 August 2014 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION David A. Minken and John P. Castagna, (2003), "Gas‐bearing hydrothermal dolomite prediction using probabilistic neural networks in the Trenton‐Black River Interval, NE Ohio," SEG Technical Program Expanded Abstracts : 450-453. https://doi.org/10.1190/1.1817948 Plain-Language Summary PDF DownloadLoading ...
Evaluation of Plastic Surgery Information on the Internet (2002)

The Internet allows vast access to medical information. Unlike most plastic surgery literature, the Internet is a quagmire of unfiltered information, not subject to peer review. To assess the accuracy of medical information on the Internet the authors studied one commonly performed elective procedure, classifying and defining the information retrieved. Using the keyword "breast augmentation," the authors compiled a list of the first 300 web sites, obtained from six distinct search engines, yielding 215 unique sites. They devised an instrument to evaluate each site for its accessibility, relevance, and accuracy. Of the 215 unique web sites evaluated, 20 were inaccessible, 24 were irrelevant, and 41 contained no medical information. Of the remaining 130 sites, almost 34% contained false or misleading information. Errors pertained most often to the technical details of the operation, potential benefits, and risks. In addition, exaggerated claims concerning alternative breast enhancement regimens, adverse sequelae of silicone breast implants, and potential effects on lactation were also seen commonly. A considerable amount of information regarding breast augmentation on the Internet was either misleading or inaccurate. Physicians can assist their patients with specific guidelines to allow them to process information discerningly, thereby diminishing the likelihood that medical decisions are based on misinformation.
Protein Conformation Significantly Influences Immune Responses to Prion Protein (2005)

In prion diseases, such as variant Creutzfeldt-Jakob disease normal cellular prion protein (PrPC), a largely alpha-helical structure is converted to an abnormal conformational isoform (PrPSc) that shows an increase in beta-sheet content. Similarly, the recombinant form of PrPC (ralpha-PrP) can be converted to a conformation dominated by beta-sheet (rbeta-PrP) by reduction and mild acidification in vitro, a process that may mimic in vivo conversion following PrPC internalization during recycling. Despite PrPSc accumulation and prion propagation in the lymphoreticular system before detectable neuroinvasion, no Ab response to PrP has been detected, probably due to immune tolerance. To investigate how the immune system may respond to alpha- and beta-PrP, we immunized Prnp(0/0) mice that are not tolerant of PrP with ralpha-PrP and rbeta-PrP. In this study, we show that although T cells stimulated by these differently folded conformers PrP recognize similar immunodominant epitopes (residues 111-130 and 191-210) the cytokine profile in response to ralpha- and rbeta-PrP was different. Challenge with ralpha-PrP elicited a strong response of IL-5 and IL-10, whereas rbeta-PrP led to an early increased production of IFN-gamma. In addition, immunization with ralpha-PrP led to production of predominantly IgG1 isotype Ab in the sera, whereas after immunization with rbeta-PrP, IgG2b was significantly produced. Thus, both humoral and cellular responses to these differently folded isoforms of the same protein are different, indicating a possible involvement of Th1 and Th2 pathway activation. These differences may be exploitable diagnostically and therapeutically for prion diseases, such as variant Creutzfeldt-Jakob disease.