gebhart/patrepeval huggingface dataset:
Thermo-Physical Properties of Ti-Coated Diamond/Al Composites Prepared by Pressure Infiltration (2010)

Thermo-physical properties of diamond reinforced Al composites were investigated. Volume fraction of diamond particles was up to 55%. In order to improve the interfacial bonding between diamond and aluminum, diamond particles were pre-coated with titanium using molten salt method. XRD and SEM observation showed that the Ti coating on diamond consists of carbide layer and metal layer, which mainly depend on temperature and time. The influences of the Ti coating on interfacial characteristic and the thermo-physical properties of the composites were studied. The interfacial characterization and thermal diffusivity measurements indicated that Ti coated diamond was more favorable on interfacial bonding and thermal properties. Ti coating on diamond resulted in an increase of thermal conductivity of the composites, from 200 to 430 W/mK along with a coefficient of thermal expansion of 6.40 × 10-6/K.
Long-term estimate of quality-adjusted life expectancy for nilotinib and imatinib as first-line treatment for newly diagnosed patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia in the chronic phase (CML-CP). (2011)

6570 Background: In the ENESTnd study, the 12-month rates of major molecular (MMR) and complete cytogenetic (CCyR) responses were significantly higher in newly diagnosed Ph+ CML-CP patients initiating nilotinib (300 mg BID) than imatinib (400 mg QD) (MMR: 44% v. 22%, respectively; CCyR: 80% v. 65%, respectively; all P<0.001). Nilotinib patients had significantly reduced progression to accelerated phase or blast crisis v. imatinib patients (P = 0.01). The objective was to model the long-term quality-adjusted life expectancy (LE) of newly-diagnosed Ph+ CML-CP patients initiating 1st-line therapy with nilotinib or imatinib in the United States. Methods: A state-transition Markov model was developed. A central model feature was the discontinuation rate of initial therapy, which was (1) based on direct observations from ENESTnd (for the first 12 months of the model) and, (2) dependent on patients' 12-month ENESTnd treatment responses and modeled from the long-term IRIS outcomes. After initial treatment discontinuation, patients were modeled to receive an additional tyrosine kinase inhibitor (TKI). Prognosis was modeled using published literature. Uncertainty was assessed using intervals comprising 95% of 1,000 model replications generated via Monte-Carlo simulations (95% credible intervals [CI]). Results: Initiating TKI therapy with nilotinib resulted in an estimated mean (95% CI) LE of 27.80 (26.38-29.08) years and quality-adjusted LE of 24.93 (23.12-26.52) years. The corresponding estimates for imatinib first-line therapy were 25.14 (23.60-26.70) years and 22.35 (20.61-24.20) years, respectively. The differences in mean (95% CI) LE and quality-adjusted LE between nilotinib and imatinib were 2.66 (1.30-4.02) and 2.58 (1.28-3.93), respective years. Conclusions: First-line nilotinib was more efficacious than imatinib in the ENESTnd trial at 12 months. As trial data collection is ongoing, modeling can be used to estimate the long-term value of these treatments. This model suggests that nilotinib is likely to substantially increase quality-adjusted LE v. imatinib.
A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function (1989)

We recently identified a novel protein tyrosine kinase that specifically phosphorylates truncated pp60c-src (Mr = 53,000) at a tyrosine residue(s) distinct from its autophosphorylation site. In this study, we examined whether this enzyme phosphorylates intact pp60c-src (Mr = 60,000) and determined its phosphorylation site. Non-neuronal and neuronal forms of intact pp60c-src were separately purified from the membrane fraction of neonatal rat brain by sequential column chromatographies. The novel kinase phosphorylated tyrosine residues of both forms of intact pp60c-src. The phosphorylation occurred in parallel with autophosphorylation of pp60c-src, and in both forms the final stoichiometry estimated was quite similar to that of autophosphorylation (about 5%). The enzyme also phosphorylated pp60c-src in which the kinase activity had been destroyed by an ATP analogue, p-fluorosulfonylbenzoyl 5'-adenosine. The phosphorylation site of the non-neuronal form was analyzed by sequential peptide mapping with tosylphenylalanyl chloromethyl ketone-treated trypsin and alpha-chymotrypsin. Tryptic digestion of the phosphorylated pp60c-src yielded a unique phosphopeptide that cross-reacted with an antibody specific for the carboxyl-terminal sequence of chicken pp60c-src. Digestion of the phosphopeptide with chymotrypsin yielded a product that comigrated with a synthetic phosphopeptide corresponding to the carboxyl-terminal 15 residues of chicken pp60c-src. These results clearly indicate that the carboxyl-terminal sequence of rat pp60c-src is identical to that of chicken pp60c-src, and a tyrosine residue corresponding to chicken Tyr527 is the phosphorylation site. This phosphorylation resulted in a decrease in the enolase phosphorylating activity of pp60c-src. Kinetic experiments indicated that this decrease in activity was due to a decrease in the Vmax value of pp60c-src. These findings support our previous proposal that the novel tyrosine kinase acts as a specific regulator of pp60c-src in cells.
Numerical Determination of the Damage Parameters of a Dual-phase Sheet Steel (2012)

Dual-phase steels show complex damage mechanisms that complicate the prediction of sheet formability. The ductile crack initiation locus (DCIL) has been developed as a failure criterion to better describe the characteristic forming behaviour in dual-phase steels. It displays the equivalent plastic strain at a critical combination of stress triaxiality and Lode angle with four damage parameters. Due to the high experimental complexity of the determination of these parameters and the missing link to the microstructure, an alternative numerical approach is of great interest. In this study, the micromechanical Gurson-Tvergaard-Needleman (GTN) model was employed to predict the damage parameters of a dual-phase steel. An adequate calibration procedure of the GTN parameters was defined with the consideration of the link between microstructural features and mechanical behaviours. After the determination of the GTN parameters, tensile tests of different specimens expressing different stress states were simulated using the GTN model. An overall good agreement was obtained for the force–displacement response. However, due to the exclusion of the Lode angle effect of the GTN model, the limitation of the capability of predicting the damage parameters in the whole stress state was also indicated and discussed.
Control of Periodicity in Mesoporous Silica Films with Aligned Mesochannels Prepared by a Sol–Gel Process (2012)

Abstract Periodicity of mesoporous silica films with aligned cylindrical pores formed on a substrate with a rubbing-treated polyimide through a sol–gel process can be finely controlled using nonionic surfactants with different alkyl chains. The degree of alignment increases with the alkyl-chain length of the surfactant due to increase in anisotropic hydrophobic interaction between the oriented polyimide chains and the alkyl groups, which is responsible for the alignment.
<title>Panel Discussion On Gap Between Optical Designers And Engineers</title> (1974)

The general form of the panel discussion was to consider several topics regarding the gap, or lack of communication, between the systems engineer and the lens designer. The first topic was that of trying to define the gap between the lens designer and the engineer and the nature of some of the problems. In this review, rather than try to ascribe a particular comment to an individual, we will simply summarize some of the pertinent points that were brought out.
SPHINGOSINE-1-PHOSPHATE AS A KEY INDUCER OF EPITHELIAL MESENCHYMAL TRANSITION IN ASTHMATIC AIRWAYS (2020)

The airway epithelium plays a key role in the protection of the internal milieu of the lung1. In this framework, the epithelial-mesenchymal trophic unit (EMTU) controls the local microenvironment ensuring lung tissue homeostasis<sup>1</sup>. In asthma alterations of this homeostatic mechanism leads to changes in lung function. In the last years it has become evident a key role for sphingosine-1-phosphate (S1P) in asthma pathogenesis<sup>2</sup>. Alterations in de novo sphingolipid metabolism lead to airway hyperreactivity (AHR), the cardinal feature of asthma, without allergic sensitization or inflammation. Here, we demonstrate that S1P administration to mice affects lung function through activation of EMTU. Bronchi, harvested from S1P-treated mice, present an increased expression of the mesenchymal and fibrosis markers coupled to a reduction of the epithelial ones. EMT well correlates to AHR, pulmonary metaplasia and increased detection of TGF-β/IL33/FGF-2levels in the lung. EMT is reproduced in vitro by incubating airway epithelial cells with either TGF-β or S1P, and it is reversed by pretreatment with LY2109761, a TGF-β antagonist. Accordingly, treatment of mice with LY2109761 abrogates S1P-induced AHR and reverses EMT. Moreover, a sphingosine kinases inhibitor prevents allergen-induced AHR and EMT as well. In conclusion, our data demonstrate that there is a direct correlation between S1P effect on airways and lung dysfunction with an obligatory role of TGF-β. <sup>1.</sup>Lambrecht BN, Hammad H: The airway epithelium in asthma. Nat Med 2012, 18(5):684-92 1 <sup>2.</sup>Ono JG, Worgall TS, Worgall S. Airway reactivity and sphingolipids-implications for childhood asthma. Mol Cell Pediatr. 2015 Dec;2(1):13.
Modelling Time, or A Step Towards Reduction-based Security Proofs for OTP and Kerberos. (2013)

The notion of time plays an important role in many practically deployed cryptographic protocols, ranging from One-Time-Password (OTP) tokens to the Kerberos protocol. However, time is difficult to model in a Turing machine environment. We propose the first such model, where time is modelled as a global counter T. We argue that this model closely matches several implementations of time in computer environments. The usefulness of the model is shown by giving complexity-theoretic security proofs for OTP protocols, HMQV-like one-round AKE protocols, and a variant of the basic Kerberos building block. 1.
General solution of the ideal model of chromatography for a single-compound band (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleGeneral solution of the ideal model of chromatography for a single-compound bandSadroddin. Golshan-Shirazi and Georges. GuiochonCite this: J. Phys. Chem. 1990, 94, 1, 495–500Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/j100364a085https://doi.org/10.1021/j100364a085research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nonlinear model-based controller for premixed charge compression ignition combustion timing in diesel engines (2023)

Advanced combustion modes, such as PCCI, operate near the system stability limits. In PCCI, the combustion event begins without a direct combustion trigger in contrast to traditional spark-ignited gasoline engines and direct-injected diesel engines. The lack of a direct combustion trigger encourages the usage of model-based controls to provide robust control of the combustion phasing. The nonlinear relationships between the control inputs and the combustion system response often limit the effectiveness of traditional, non-model-based controllers. Accurate knowledge of the system states and inputs is helpful for implementation of an effective nonlinear controller. A nonlinear controller is developed and implemented to control the engine combustion timing during diesel PCCI operation by targeting desired values of the in-cylinder oxygen concentration, pressure, and temperature during early fuel injection.
ChemInform Abstract: Stereospecific Insertion of Germylene into the Vinyl Chloride Bond. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antimicrobial Resistance and Urinary Tract Infection Recurrence (2016)

Although TMP-SMX resistance is more common among children treated with TSP versus placebo, resistance decreased over time. Among children treated with TSP, there was no significant difference in UTI recurrence between those with TMP-SMX-resistant index UTI versus TMP-SMX-susceptible UTI.
Linear Unbiased Channel Estimation and Data Detection in Superimposed OFDM Systems (2012)

Reliable channel estimation is necessary for orthogonal frequency-division multiplexing (OFDM) systems employing coherent detection to achieve high data rates. Pilot-aided detection algorithms benefit from rapid convergence, but suffer from non-efficient bandwidth usage. The idea of superimposed data transmission can be enabled for channel estimation without sacrificing the data rate. In this paper, we first derive the best linear unbiased estimator (BLUE) for channel impulse response and then, we propose an iterative joint channel estimator and data detector to improve the performance of both the estimator and the detector. Furthermore, we derive the variance of the proposed estimator and show that the equispace and equipower conditions hold for the superimposed pilots to attain the minimum variance of the estimator. Simulations show that the performance with perfect knowledge of the channel impulse response can be achieved closely by the proposed iterative data detector.
Microwave‐Assisted Claisen Rearrangement on a Silica Gel Support. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Layer-structured silver nanowire/polyaniline composite film as a high performance X-band EMI shielding material (2016)

The superiority of layer-structured Ag-NW/PANI composite films over the plain-structured in electrical conductivity and electromagnetic interference shielding.
Developing a safe antifungal treatment protocol to eliminateBatrachochytrium dendrobatidisfrom amphibians (2010)

Batrachochytrium dendrobatidis is one of the most pathogenic microorganisms affecting amphibians in both captivity and in nature. The establishment of B. dendrobatidis free, stable, amphibian captive breeding colonies is one of the emergency measures that is being taken to save threatened amphibian species from extinction. For this purpose, in vitro antifungal susceptibility testing and the development of efficient and safe treatment protocols are required. In this study, we evaluated the use of amphotericin B and voriconazole to treat chytridiomycosis in amphibians. The concentration at which the growth of five tested B. dendrobatidis strains was inhibited was 0.8 μg/ml for amphotericin B and 0.0125 μg/ml for voriconazole. To completely eliminate a mixture of sporangia and zoospores of strain IA042 required 48 h of exposure to 8 μg/ml of amphotericin B or 10 days to 1.25 μg/ml of voriconazole. Zoospores were killed within 0.5 h by 0.8 μg/ml of amphotericin B, but even after 24 h exposure to 1.25 μg/ml of voriconazole they remained viable. Amphotericin B was acutely toxic for Alytes muletensis tadpoles at 8 μg/ml, whereas toxic side effects were not noticed during a seven-day exposure to voriconazole at concentrations as high as 12.5 μg/ml. The voriconazole concentrations remained stable in water during this exposure period. On the basis of this data, experimentally inoculated postmetamorphic Alytes cisternasii were sprayed once daily for 7 days with a 1.25 μg/ml solution of voriconazole in water which eliminated the B. dendrobatidis infection from all treated animals. Finally, treatment of a naturally infected colony of poison dart frogs (Dendrobatidae) using this protocol, combined with environmental disinfection, cleared the infection from the colony.
Reliability of three-dimensional ferroelectric capacitor memory-like arrays simultaneously submitted to x-rays and electrical stresses (2006)

Future development of Ferroelectric Random Access Memories (FeRAM) requires integration of three-dimensional (3D) ferroelectric capacitors in replacement of usual planar capacitors. This innovative geometry enables the fabrication of highly reliable memory devices with improved sensing signal. In order to target space applications, it is of primary interest to analyze the effects of ionizing radiations (x-rays, X-rays...) on capacitors integrated in advanced memory architectures. In this paper, effects of x-rays combined with either bias voltage or bipolar electrical cycling were analyzed on 3D ferroelectric capacitor memory-like arrays. Using an experimental setup enabling measurements under radiations, these arrays were submitted to electrical stresses simulating the various states of the memory. For memory-like arrays in "written" state (no applied bias), high dose of X-rays accelerates both fatigue-like (polarization reduction) and imprint-like (voltage shift) phenomena, which may subsequently alter normal memory operations. Nevertheless, it has been shown that repeated cycling makes the degradation mechanisms reversible. Alternatively, for memory-like arrays in "writing" state, two distinct simulated conditions have been considered. If irradiated capacitors are always being written in the same state, huge and irreversible imprint-like effect may cause memory cell "read" or "write" failures. Moreover, if capacitors are cycled in normal conditions (i e. bipolar pulses), the strong acceleration of fatigue mechanism may cause "read" failures since the two remnant states may be indistinguishable during memory reading.
Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24) (1983)

The leukemia-associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. ALB6 IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, ALB6 Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALB6 IgG. The results suggest that ALB6 interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.
Cryptic epitope for antibodies should not be forgotten in vaccine design (2016)

Vaccines have been licensed to prevent infection with approximately 25 different organisms [1]; of these, one-third are subunit vaccines containing critical antigens capable of inducing protective antibodies against single strains. The challenge is that many organisms have multiple strains. For this reason, vaccines have only been developed against two diversified organisms – Streptococcus pneumoniae and Human Papilloma Virus – using a polyvalent vaccine approach.
Advances in the experimentation of extremum seeking techniques to maximize the RF power absorption in FTU (2005)

In this paper we report on the advances in the experimentation of extremum seeking techniques on the horizontal positioning system of the plasma in the Frascati Tokamak Upgrade (FTU). The dynamic extremum seeking technique had already shown very desirable results on the experimentation on one of the LH grills available at FTU. We report here on new experimental results where the experimentation is extended to two grills, consisting of a total of 2times8=16 waveguides. Additional results will be presented on the use of a modified extremum seeking algorithm to increase the robustness of the approach toward disturbances affecting the measurement of the reflected power. The experiments are carried out by relying on a reduced set of on-line measurements to keep the architecture of the control system simple. It is shown that the reduced measures are sufficient to gather the necessary information on the reflected power on each grill
Quantitative Structure−Activity Relationship of Botanical Sesquiterpenes: Spatial and Contact Repellency to the Yellow Fever Mosquito, Aedes aegypti (2009)

The plant terpenoids encompass a diversity of structures and have many functional roles in nature, including protection against pest arthropods. Previous studies in this laboratory have identified naturally occurring sesquiterpenes contained in essential oils from two plants, amyris (Amyris balsamifera) and Siam-wood (Fokienia hodginsii), that are significantly repellent to a spectrum of arthropod pests. In efforts to further examine the biological activity of this class of compounds 12 of these plant-derived sesquiterpenes have been isolated, purified, and assayed for spatial and contact repellency against the yellow fever mosquito, Aedes aegypti . These data were used to develop quantitative structure-activity relationships that identified key properties of the sesquiterpene molecule, including electronic and structural parameters that were used to predict optimal repellent activity. There were notable similarities in the models developed for spatial repellency over five time points and for contact repellency. Vapor pressure was an important component of all repellency models. Initial levels of spatial repellency were also related to polarizability of the molecule and lowest unoccupied molecular orbital (LUMO) energy, whereas the equation for late spatial repellency was dependent on other electronic features, including Mulliken population and electrotopological state descriptors. The model identified for contact repellency was the best fit and most significant model in this analysis and showed a relationship with vapor pressure, Mulliken population, and total energy.
By any other name? The Women and Geography Study Group (2013)

<br/><br/>If one grants that meanings are constructed through exclusions, one must acknowledge and take responsibility for the exclusions involved in one's own project. (Wallach Scott 1988, 7)<br/><br/>Names can be important, as an identity marker and public persona, especially if they shape our own and others' expectations – ask any woman named Hope or Patience. In this short piece we consider what the Women and Geography Study Group of the Royal Geographical Society (with IBG) represents to both those inside and outside the group in the 21st century and make a case for change to a more inclusionary title.<br/>