gebhart/patrepeval huggingface dataset:
Cardiovascular Autonomic Neuropathy as a New Complication of Postsurgical Chronic Hypoparathyroidism (2018)

ABSTRACT Postsurgical hypoparathyroidism (hypoPT) increases fatigue and seems to affect the risk of mortality. Cardiovascular autonomic neuropathy (CAN) is an impairment of the cardiovascular autonomic system, a cause of increased mortality, and associated with increased fatigability. The aim of this study is to evaluate CAN in hypoPT and its relationship with hypocalcemia, PTH levels, and hyperphosphatemia. This is a cross-sectional study comparing 51 postsurgical hypoPT patients treated with calcium and calcitriol and 43 control subjects without any PTH/calcium/phosphate disorders who underwent thyroidectomy. CAN was assessed by heart rate (HR) response to deep breathing, HR response to the lying-to-standing test, HR response to the Valsalva maneuver, and blood pressure response to standing. Participants were considered to have “early CAN” if they had one abnormal result in the HR tests and “definite CAN” with two or more abnormal results. The prevalence of CAN was 23% in the control group and 78% in the hypoPT group (OR 11.48; 95% CI, 4.48 to 32.17). Patients with hypoPT and serum calcium (sCa) ≥8.5 mg/dL had a prevalence of early CAN of 72.4% and the prevalence was 86.4% in those with sCa &amp;lt;8.5 mg/dL. Definite CAN was found in 2.3% of the control group, 24.1% of the hypoPT group without hypocalcemia, and 59.1% of the hypoPT group with hypocalcemia. In the hypoPT group, the OR for definite CAN in the patients with hypocalcemia compared to the patients with normocalcemia was 4.54 (95% CI, 1.36 to 15.11). The association between low sCa and definite CAN was confirmed after adjustment for confounders with OR 13.62 (95% CI, 2.12 to 149.84). No association was found between definite CAN and PTH levels or high phosphate levels. HypoPT is associated with CAN and hypocalcemia seems to affect its severity. Larger and prospective studies are needed to confirm our findings. © 2018 American Society for Bone and Mineral Research.
ChemInform Abstract: Synthesis of Oxazolidin‐4‐ones: Domino O‐Alkylation/Aza‐Michael/Intramolecular Retro‐Claisen Condensation. (2016)

ChemInformVolume 47, Issue 39 Heterocyclic Compounds ChemInform Abstract: Synthesis of Oxazolidin-4-ones: Domino O-Alkylation/Aza-Michael/Intramolecular Retro-Claisen Condensation. Abderrahman El Bouakher, Abderrahman El Bouakher URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorRonan Le Goff, Ronan Le Goff URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorJordan Tasserie, Jordan Tasserie URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorJerome Lhoste, Jerome Lhoste URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorArnaud Martel, Arnaud Martel URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorSebastien Comesse, Sebastien Comesse URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this author Abderrahman El Bouakher, Abderrahman El Bouakher URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorRonan Le Goff, Ronan Le Goff URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorJordan Tasserie, Jordan Tasserie URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorJerome Lhoste, Jerome Lhoste URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorArnaud Martel, Arnaud Martel URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this authorSebastien Comesse, Sebastien Comesse URCOM, Univ. Le Havre, F-76058 Le Havre, Fr.Search for more papers by this author First published: 08 September 2016 https://doi.org/10.1002/chin.201639139Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume47, Issue39September, 2016 RelatedInformation
Measuring Docker Performance (2017)

Today, a new technology is going to change the way platforms for the internet of services are designed and managed. This technology is called container (e.g. Docker and LXC). The internet of service industry is adopting the container technology both for internal usage and as commercial offering. The use of container as base technology for large-scale systems opens many challenges in the area of resource management at run-time, for example: autoscaling, optimal deployment and monitoring. Specifically, monitoring of container based systems is at the ground of any resource management solution, and it is the focus of this work. This paper explores the tools available to measure the performance of Docker from the perspective of the host operating system and of the virtualization environment, and it provides a characterization of the CPU and disk I/O overhead introduced by containers.
Engineering Considerations of the Toowoomba Region Transport Network Study (1996)

Planning for the second road crossing of the Great Dividing Range near Toowoomba is nearing completion after 27 months study involving extensive community consultation, environmental assessment and engineering investigation of route options. The proposed route of the new highway between the Warrego Highway at Postmans Ridge and the Gore Highway near Athol, via Mt Kynoch has been selected to address the community and environmental issues raised during the study. The route passes through a variety of terrain ranging from steep undisturbed areas east of the Range to the undulating terrain of the agricultural land to the west. This paper will generally discuss the engineering features in planning the new road, including transport planning considerations, alignment, geotechnical and environmental details. Community consultation has been important to the route choice, and the paper will discuss the engineering decisions taken to address community issues.
Physical and mechanical characterization and the influence of cyclic loading on the behaviour of nickel‐titanium wires employed in the manufacture of rotary endodontic instruments (2005)

The mechanical behaviour of the NiTi wires was modified slightly by cyclic tensile loading in the superelastic plateau. As the changes tended towards stabilization, the clinical use of rotary NiTi ProFile instruments does not compromise their superelastic properties until they fracture by fatigue or torsional overload, or are otherwise discarded.
Nucleotide sequence of the barley chloroplast psbA gene for the QBprotein of photosystem II (1988)

Journal Article Nucleotide sequence of the barley chloroplast psbA gene for the Q B protein of photosystem II Get access V.A. Efimov, V.A. Efimov Shemyakin Institute of Bioorganic Chemistryul.Miklukho-Maklaya 16/10, 117871 Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar A.V. Andreeva, A.V. Andreeva Shemyakin Institute of Bioorganic Chemistryul.Miklukho-Maklaya 16/10, 117871 Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar S.V. Reverdatto, S.V. Reverdatto Shemyakin Institute of Bioorganic Chemistryul.Miklukho-Maklaya 16/10, 117871 Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Jung, R. Jung Shemyakin Institute of Bioorganic Chemistryul.Miklukho-Maklaya 16/10, 117871 Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar O.G. Chakhmakhcheva O.G. Chakhmakhcheva Shemyakin Institute of Bioorganic Chemistryul.Miklukho-Maklaya 16/10, 117871 Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 12, 24 June 1988, Page 5685, https://doi.org/10.1093/nar/16.12.5685 Published: 24 June 1988 Article history Accepted: 19 May 1988 Published: 24 June 1988
An Improved Workflow for miRNA Expression Profiling Using Ion Semiconductor Sequencing (2012)

MicroRNAs (miRNAs) are non coding RNA molecules with a size range of 18 to 24 nucleotides that have important functions in regulating numerous cellular processes. Several technologies such as microarrays, real-time PCR and second-generation deep sequencing have been used to profile miRNA expression and characterize variances in miRNA species. This study focuses on miRNA expression profiling using ion semiconductor sequencing with an improved workflow that utilizes multi-channel microfluidics to isolate miRNAs from total RNA. This microfluidics approach replaces polyacrylamide gel electrophoresis for size fractionation and enrichment of miRNAs commonly used in sequencing protocols. We compared miRNA expression profiles of commercially available preparations of lung and brain total RNA obtained by ion semiconductor sequencing, second-generation sequencing and real-time PCR array. We show that ion semiconductor sequencing using our improved workflow with the microfluidics device produced similar miRNA expression profiles compared to polyacrylamide gel based methods. We also detected similar numbers of miRNAs compared to second-generation deep sequencing. Finally, we were able to validate our results using a commercially available real-time PCR based miRNA array. Our workflow streamlines and significantly improves the utilization of semiconductor sequencing for miRNA profiling both in a research and clinical environment.
Research on Track and Field training System Based on Network Technology (2016)

Track and field training is a practical and highly participatory training and learning of bilateral activities, less network resources compared to other disciplines, and the lack of systematic and complete. So in this context, relying more mature college campus network, based on Internet technology, computer technology, multimedia technology, modern communication technology, design and development of an oriented the track and field network training platform is very necessary. Based on computer network technology, multimedia technology and modern communications technology, this paper designs and develops interactive network training platform for the college track and field training and track and Field daily management.
Simple linear interpolation explains all usual choices in fuzzy techniques: Membership functions, t-norms, t-conorms, and defuzzification (2015)

Most applications of fuzzy techniques use piece-wise linear (triangular or trapezoid) membership functions, min or product t-norms, max or algebraic sum t-conorms, and centroid defuzzification. Similarly, most applications of interval-valued fuzzy techniques use piecewise-linear lower and upper membership functions. In this paper, we show that all these choices can be explained as applications of simple linear interpolation.
Design and Implementation of a Novel Polarimetric Active Radar Calibrator for Gaofen-3 SAR (2018)

The Chinese first fully polarimetric space-borne synthetic aperture radar (SAR)-Gaofen-3 (GF-3) was launched in August 2016, which operates at the C-band and the resolution can reach 1 m. Polarimetric SAR calibration is a procedure that corrects the polarization distortion of a measured scattering matrix by referring to the scattering matrix of a known target. The present paper describes the principle, design, manufacture, and measurement results of a novel polarimetric active radar calibrator (PARC) designed for GF-3. A new design method for PARC was presented and two dual-polarized antennas with very high polarization purity were used. The internal calibration technique was introduced to ensure balance in the amplitude and phase, which ensures the precision of the PARC's scattering matrices. The results we obtained through measurement in the microwave anechoic chamber and experiments in in-orbit calibration agree well with the theoretical predictions, and the novel PARC presented is proved to be well suited for polarization and radiometric calibration of GF-3.
SERS using two-photon polymerized nanostructures for mycotoxin detection (2020)

Improved chemical- and bio-sensing with Surface Enhanced Raman Spectroscopy (SERS) requires nanostuctures that can be flexibly designed and fabricated with different physical and optical properties. Here, we present nano-pillar arrays ranging from 200 nm to 600 nm as SERS substrates for mycotoxin detection that are fabricated by means of two-photon polymerization. We built a nominal shape and a voxel-based model for simulating the enhancement of the electric field of the nano-pillar arrays using the Finite-Difference Time-Domain (FDTD) method. A new model was built based on the Atomic Force Microscopy (AFM) data obtained from the fabricated nanostructures and introduced into a FDTD model. We demonstrated the enhancement behavior by measuring the Raman spectrum of Rhodamine B solutions. Both the simulations and experimental results suggest that the 200 nm nano-pillar array has the highest Enhancement Factor (EF). Besides, we determined the limit of detection of the 200 nm pillar array by performing Raman measurements on Rhodamine B solutions with different concentrations. The detection limit of our 200 nm nano-pillar array is 0.55 μM. Finally we discriminated 1 ppm deoxynivalenol and 1.25 ppm fumonisin b1 in acetonitrile solutions by our SERS substrate in combination with principal component analysis. This versatile approach for SERS substrates fabrication gives new opportunities for material characterization in chemical and biological applications.
Inequidistant gearing used to reduce gear noise (2016)

Tonal noise is considered annoying. Unlike broadband noise, tonal noise is hard for the human brain to ignore. State-of-the-art gears primarily radiate this annoying tonal noise, which is caused by the regularly positioned teeth along the pitch circle of the gearwheel. In this paper, the inequidistant gearing will be presented. The principle of the regularly positioned (equidistant) teeth will be transgressed. When the positions of the teeth are variable, the gears generate less tonal noise. Therefore, their noise is less annoying. Thus, the radiated sound pressure level and the psychoacoustic loudness can be reduced. A theoretical investigation of the emergence of the gear noise of inequidistant gears will be shown, followed by the design of a set of spur gears with inequidistant gearing. The benefits and challenges of this new design will be discussed. A comparison of the experimental results from the gears with inequidistant and equidistant gearing will be presented and discussed. From this, a reduction of the sound pressure level, the psychoacoustic loudness, and the psychoacoustic annoyance can be achieved.
Procedural Generation of Rock Piles using Aperiodic Tiling (2009)

Abstract In this paper, we present a tiling method for generating piles of rocks without any computationally demanding physically‐based simulation. Previous techniques rely on a periodic tiling of rocks and generate unrealistic repetitive patterns. In contrast, our approach relies on a modified corner cube algorithm to generate a set of aperiodic tiles. We generalize the construction method so that the geometry of rocks should straddle corner cubes with a view to avoiding unrealistic gaps in the arrangement of rocks. Moreover, we propose an original technique to control the shape of rocks into contact by computing the Voronoï cells using a parameterized anisotropic distance. Our method has been successfully used to generate landscapes and stone huts and walls with thousands of rocks piled together.
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome (2021)

Inflammasome signaling is kept in check by the kinase Lyn.
Pressure-Volume Behavior and Radiation-Induced Polymerization of Acrylic Acid-Formamide Binary System at High Pressure (1979)

Abstract Pressure-volume (P-V) measurements and radiation-induced polymerization of the acrylic acid (AA)-formamide (FA) binary system were carried out at 5 to 60°C and 1 to 8000 kg/cm2. The mixture containing 25 vol % of FA attained the glassy state at about 5000 kg/cm2 at 20°C. The rate of polymerization at 20°C increased with increasing pressure up to 3800 kg/cm2 and then decreased abruptly at 4000 kg/cm2. Overall activation volume changed with pressure and abrupt change in activation volume was not observed. The polymerization proceeded in the glassy state, and the rate increased with increasing pressure. When the polymerization temperature was varied at 3000 kg/cm2, the rate was maximum at somewhat above the glass transition temperature. These results indicate that pressure-induced short-range order of the monomer molecules does not occur in the system having weak intermolecular interaction, and glassy states produced by compression and lowering temperature differ in the physical state.
Synthese von potentiellen Naftopidil‐Metaboliten (1993)

Abstract Es wird über die Synthese von vier potentiellen Metaboliten [Desmethyl‐Naftopidil ( 1 ), 4‐(Phenyl)‐hydroxy‐Naftopidil ( 2 ), 4‐(Naphthyl)‐hydroxy‐Naftopidil ( 3 ), Desanaphthyl‐Naftopidil ( 4 )] des selektiven α 1 ‐Antagonisten Naftopidil berichtet.
The Role of Histamine in Acute Experimental Ascariasis (1966)

Spectrofluorometric analysis of tissue levels of histamine, estimation of the toxicity of histamine intracardially and as an aerosol, and determination of histaminase activity of various tissues were performed in normal guinea pigs and those infected orally with Ascaris suum. Increases in blood and tissue histamine content were not observed and significant decreases were found in the lungs and brain of 6-day infected animals. Infected guinea pigs were more resistant to histamine admin- istered intracardially and by aerosol. Diamineoxidase-like activity of liver appeared enhanced but aminoguanidine-iproniazid administration did not cause loss of resistance to histamine aerosol.
Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis (2011)

Antibodies to Ro52 alone and antibodies to Ro52 in conjunction with antibodies to soluble liver antigen are independently associated with a poor prognosis in type 1 autoimmune hepatitis. The prognostic implications ascribed to antibodies to soluble liver antigen may reflect their almost invariable concurrence with antibodies to Ro52.
<title>Driving nonlinear systems with chaotic signals</title> (1992)

Recent work using chaotic signals to drive nonlinear systems shows that chaotic dynamics is rich in new application possibilities. The approach of using nonlinear dynamics concepts to guide synthesis of new nonlinear systems leads to the concepts of synchronization of chaotic systems and pseudoperiodic driving. These are only the beginnings of new and unique uses of chaotic dynamics.
Lectin Functionalization by Post-Photo Affinity Labeling Modification (P-PALM) (2007)

我々の開発した光アフィニティーラベル化後修飾法 (P-PALM) は、タンパク質の活性部位近傍に部位特異的に人工分子を導入できる優れた手法である。糖結合性タンパク質 (レクチン) に対してこの手法を適用することで、様々な機能化を行った。例えばP-PALMにより蛍光色素を導入することで、糖との結合を蛍光変化により読み出す蛍光性の糖鎖センサーを構築した。さらに、このセンサーに別の蛍光団を選択的に導入することで、測定精度を向上させ細胞内での糖鎖検出に成功した。またセンサー化のみならず、副結合部を導入することでレクチンの糖選択性の改変も行った。このようにP-PALMを用いることでレクチンを分子レベルで機能化することができ、新たな糖鎖解析のツールとして糖鎖研究にさらなる発展をもたらすことが期待される。
Redox Interactions of Cr(VI) and Substituted Phenols: Products and Mechanism (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRedox Interactions of Cr(VI) and Substituted Phenols: Products and MechanismMichael S. Elovitz and William. FishCite this: Environ. Sci. Technol. 1995, 29, 8, 1933–1943Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/es00008a010https://doi.org/10.1021/es00008a010research-articleACS PublicationsRequest reuse permissionsArticle Views747Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Murine Model of Acute Liver Injury Induced by Human Monoclonal Autoantibody * (2005)

We have previously reported an immunoglobulin (Ig) M autoantibody to hepatocyte-related 190-kd molecules in patients with type 1 autoimmune hepatitis (AIH). This molecule was first isolated by hepatocyte-specific human monoclonal antibody (MoAb). To elucidate the role of this IgM autoantibody in hepatocyte injury, we examined the reactivity of this MoAb to murine hepatocytes and then questioned whether acute hepatic injury could be induced in mice via injection of this MoAb. The reactivity of MoAb was examined via both FACS analysis using murine hepatocytes and immunostaining of liver tissues. We then identified the murine hepatocyte membrane molecule recognized by this MoAb. The role of this MoAb in the immunopathogenesis of AIH was assessed by testing whether its injection into mice could increase serum aminotransferase levels as well as cause changes in liver histology. The present results demonstrate that this MoAb cross-reacted with murine hepatocytes and recognized a 190-kd molecule on the murine hepatocyte membrane just as in human hepatocytes. One hour after the injection of MoAb, the deposition of both IgM and complement component 3 was found in liver tissues. At 8 hours after the injection, serum aminotransferase levels were significantly increased in MoAb-injected mice compared with controls. Histological study revealed massive hepatocyte necrosis in MoAb-injected mice. In conclusion, human MoAb recognized a 190-kd molecule of both human and murine hepatocytes, and the injection of this MoAb to mice resulted in acute liver injury, indicating that this type of autoantibody may play an important role in the immunopathogenesis of AIH.
Decision support methodology for evolutionary embedded system design (2019)

Design decisions are made in an early-design phase of system development. These decisions have a big impact on the resulting system design and realization. Making design decisions in this stage is a complex and risky task, because there are a lot of uncertainties regarding their impact on the system qualities. Moreover, in many cases, trade-offs have to be made when there are conflicting objectives. This paper presents a methodology to support decision making for evolutionary systems, to decide on the most suitable design. The focus is on the embedded part of a system. Information is structured with explicit relations, such that the realization of a design can be traced towards the concerns a stakeholder has for the system. This structure enables architects and designers to understand and reason about the impact of a design with a system-wide perspective. The method consists of a calibration step which imports a current design, a design exploration step in which designs are selected, and a decision step where the most suitable design is chosen. The methodology is demonstrated by exploring and revealing the trade-offs for platooning designs from the automotive domain.