gebhart/patrepeval huggingface dataset:
Impact of G-CSF during neoadjuvant therapy on outcomes of operable pancreatic cancer. (2021)

4126 Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by chronic inflammation and a tolerogenic immune response. Neutropenia is a common side effect of cytotoxic chemotherapy, managed with administration of recombinant granulocyte-colony stimulating factor (G-CSF, Filgrastim). The interleukin 17 – G-CSF – neutrophil extracellular trap (NET) axis promotes oncogenesis and progression of PDAC, inhibiting adaptive immunity. We evaluated the impact of G-CSF administration during neoadjuvant therapy (NAT) on oncologic outcomes in patients with operable pancreatic cancer. Methods: A retrospective review of all patients with localized PDAC treated with NAT prior to pancreatic resection between 2014 – 2020 was completed at a single institution. G-CSF administration, type, and dose were collected from inpatient and outpatient medical records. Results: Of 351 patients treated, 138 (39%) received G-CSF during NAT with a median follow-up of 45.8 months. Patients who received G-CSF were younger (64.0 vs 66.7, p = 0.008), had lower BMI (26.5 vs 27.9, p = 0.021), and were more likely to receive 5-FU based chemotherapy (42% vs 28.2%, p &lt; 0.0001), NAT dose reduction (40.6% vs 25.4%, p = 0.003), or experience febrile neutropenia (8.7% vs 3.3%, p = 0.029). No differences were observed in baseline or pathologic tumor staging. In patients who received G-CSF, 130 (94%) received Pegfilgrastim with a median cumulative dose of 12 mg (IQR 6-12). Patients who received G-CSF were more likely to have an elevated post-NAT neutrophil to lymphocyte ratio (45% vs 29.6%, p = 0.004) and systemic immune-inflammation index (39.5% vs 29.6%, p = 0.061). Receiving G-CSF was an independent predictor of perineural invasion (HR 2.4, 95 CI [1.08, 5.5], p = 0.031) and margin positive resection (HR 1.69, 95 CI [1.01, 2.83], p = 0.043). Patients who received G-CSF had decreased overall survival compared to patients who did not receive G-CSF (median OS: 29.2 vs 38.7 months, p = 0.0001). Receiving G-CSF during NAT was an independent negative predictor of progression free (HR 1.38, 95 CI [1.04, 1.83], p = 0.022) and overall survival (HR 2.02, 95 CI [1.45, 2.79], p &lt; 0.0001). In a subset of patients with available pre- and post-NAT serum specimens (n = 28), G-CSF administration resulted in an increased number of citrullinated histone H3 complexes following NAT (+1378±1502 vs -300.7±1147 pg/ml, p = 0.007), indicative of enhanced peripheral NET formation. Conclusions: In patients with localized PDAC receiving NAT prior to surgical extirpation, G-CSF administration is associated with worse oncologic outcomes and should be administered with caution. Prospective randomized as well as confirmatory clinical studies are in order.
The Cytotoxic Effect of Curcumin in Rhabdomyosarcoma Is Associated with the Modulation of AMPK, AKT/mTOR, STAT, and p53 Signaling (2023)

Approximately 7% of cancers arising in children and 1% of those arising in adults are soft tissue sarcomas (STS). Of these malignancies, rhabdomyosarcoma (RMS) is the most common. RMS survival rates using current therapeutic protocols have remained largely unchanged in the past decade. Thus, it is imperative that the main molecular drivers in RMS tumorigenesis are defined so that more precise, effective, and less toxic therapies can be designed. Curcumin, a common herbal supplement derived from plants of the <i>Curcuma longa</i> species, has an exceptionally low dietary biotoxicity profile and has demonstrated anti-tumorigenic benefits in vitro. In this study, the anti-tumorigenic activity of curcumin was assessed in rhabdomyosarcoma cell lines and used to identify the major pathways responsible for curcumin's anti-tumorigenic effects. Curcumin treatment resulted in cell cycle arrest, inhibited cell migration and colony forming potential, and induced apoptotic cell death. Proteome profiler array analysis demonstrated that curcumin treatment primarily influenced flux through the AKT-mammalian target of rapamycin (mTOR), signal transducer and activator of transcription (STAT), AMP-dependent kinase (AMPK), and p53 associated pathways in a rhabdomyosarcoma subtype-specific manner. Thus, the strategic, combinational therapeutic targeting of these pathways may present the best option to treat this group of tumors.
An Analysis of Fixed Pattern Noise (FPN) for the Amplified MOS Intelligent Imager (1990)

2/3インチ型25万画素で試作した増幅型固体撮像素子AMIの固定パターン雑音 (FPN) の成因を調べた結果, 暗時のFPNの主たる原因は, 各画素毎に持っている増幅用FETの閾値電圧の不揃いであり, 利得の不均一や, フォトダイオードの暗電流の不均一によるものではないことが明らかとなった.暗時に観測されるFPNの値は飽和信号量に対して-56.0dB (rms) であり, 増幅用FETの閾値電圧に換算すると約±12mV (pp) の不均一性に相当することがわかった.また, このFPNは加算性成分であるため, メモリーを用いた減算処理で他の特性に何の影響も与えずに18dB以上の改善が25万画素AMIでもリアルタイムでできることを確認した.一方, 光入射時に観測されるFPNは, 開口率, 光電変換率, 浮遊容量の各不均一性が総合されたものであることも明らかとなった.これは入射光に比例するFPNなので, 実際の画面上では見えにくい.
Rapid Three-Dimensional Echocardiography (2001)

The rapid-acquisition 3D echocardiography extends the use of a multiplane, internally rotating handheld transducer so that it becomes a precise and clinically feasible tool for assessing left ventricular volumes and function. A rapid-image acquisition time of 6 s would allow repeated image collection during the course of a clinical echocardiographic examination. Additional work must address rapid and automated data processing.
[Protein expression profilings of polycystic ovary syndrome]. (2005)

Using ProteinChip technology can screen out serum discriminatory proteins quickly and efficiently. Combined with SVM, an optimal fingerprinting model has been set up, which can easily predict PCOS. In disease state of PCOS, there are significant variations which consist of four proteins. To investigate those four discriminatory proteins, especially the protein m/z 6 628 may be of benefit to pathogenic study and the development of biomarkers for PCOS.
Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes (2018)

The direct synthesis of C(CF<sub>3</sub>)Me<sub>2</sub>-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and the base is crucial for this reaction. A series of previously unknown C(CF<sub>3</sub>)Me<sub>2</sub>-containing heteroarenes were obtained in high yields and have potential applications in the drug discovery process.
Anti-Inflammatory and Anti-Diabetic Activity of Ferruginan, a Natural Compound from Olea ferruginea (2023)

Inflammation is a complex response of the human organism and relates to the onset of various disorders including diabetes. The current research work aimed at investigating the anti-inflammatory and anti-diabetic effects of ferruginan, a compound isolated from Olea ferruginea. Its in vitro anti-inflammatory activity was determined by using the heat-induced hemolysis assay, while the anti-diabetic effect of the compound was studied by the yeast cell glucose uptake assay. Ferruginan exhibited a maximum of 71.82% inhibition of inflammation and also increased the uptake of glucose by yeast cells by up to 74.96% at the highest tested concentration (100 µM). Moreover, ferruginan inhibited α-amylase dose-dependently, by up to 75.45% at the same concentration. These results indicated that ferruginan possesses promising anti-inflammatory and anti-diabetic properties in vitro, even if at high concentrations. To provide preliminary hypotheses on the potentially multi-target mechanisms underlying such effects, docking analyses were performed on α-amylase and on various molecular targets involved in inflammation such as 5′-adenosine monophosphate-activated protein kinase (AMPK, PDB ID 3AQV), cyclooxygenase (COX-1, PDB ID 1EQG, and COX-2, 1CX2), and tumor necrosis factor alpha (TNF-α, PDB ID 2AZ5). The docking studies suggested that the compound may act on α-amylase, COX-2, and AMPK.
Metal–Organic Frameworks (MOFs) as Safer, Structurally Reinforced Energetics (2012)

Second-generation cobalt and zinc coordination architectures were obtained through efforts to stabilize extremely sensitive and energetic transition-metal hydrazine perchlorate ionic polymers. Partial ligand substitution by the tridentate hydrazinecarboxylate anion afforded polymeric 2D-sheet structures never before observed for energetic materials. Carefully balanced reaction conditions allowed the retention of the noncoordinating perchlorate anion in the presence of a strongly chelating hydrazinecarboxylate ligand. High-quality X-ray single-crystal structure determination revealed that the metal coordination preferences lead to different structural motifs and energetic properties, despite the nearly isoformulaic nature of the two compounds. Energetic tests indicate highly decreased sensitivity and DFT calculations suggest a high explosive performance for these remarkable structures.
Calliphoridae (Diptera) on Decomposing Pig Carcasses and Human Cadavers in the Upper Midwest of North America (2021)

Abstract The geographic ranges of forensically informative taxa on decomposing remains vary across regions. To determine which calliphorid flies would be expected to occur in Minnesota and the upper Midwest, individual freshly killed pig carcasses (Sus scrofa L.) were placed in the field in St. Paul, MN, at monthly intervals from May to October 2017 and May to September 2018. Aerial nets, forceps, and pitfall traps were used to collect and preserve associated adult and immature insects. Sixty-four forensically informative insect taxa were recorded, representing three insect orders and 14 families. Ten informative calliphorid species were recorded on carcasses, adding four new Minnesota records. Comparison of species lists from 26 human forensic cases indicated agreement between the two lists, except for Lucilia coeruleiviridis Macquart, Calliphora vomitoria (L.), and Cynomya cadaverina Robineau-Desvoidy, which occurred on pig carcasses but not human remains, and Calliphora livida Hall, which occurred on human remains, but not carcasses. The composite fauna list from cadavers agreed largely with the 2-yr list from pig carcasses.
Schematics for gating the NMR via myocardial pressure measurements (1985)

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Contact Urticaria Syndrome and Claims Support (1999)

Contact urticaria syndrome (CUS) was first defined by Maibach and Johnson [28], and since then numerous reports of contact urticaria to a variety of compounds such as foods, preservatives, fragrances, plant and animal products, metals and others, continue to be reported. Therefore, it is important to determine, in a scientific manner, whether or not a particular substance causes contact urticaria, and in what dose. Accurate experimental models are required to document urticaria-inducing properties of a substance; we also propose protocols to quantify efficacy of formulations that putatively inhibit CUS.
Thermal degradation of InGaN/GaN LEDs ohmic contacts (2008)

Abstract This paper reports an analysis of the high temperature degradation of GaN‐based LEDs. It is shown that exposure to high temperatures implies (i) the decrease of the emitted optical power, (ii) the crowding of the emission profile around the central pad and (iii) the increase of the operating voltage of the devices. Degradation is attributed to the interaction between the PECVD SiN passivation layer and the ohmic contacts at the surface of the devices: by means of the Transmission Line Method the degradation of the p‐side contacts is analyzed in detail. It is shown that high temperature treatment implies the increase of the contact resistivity of the metal/semiconductor (M/S) interface, and a slight variation of the sheet resistance of the semiconductor layer: these processes are responsible for the emission crowding and efficiency decay measured as a consequence of stress on the LEDs. Finally, it is shown that the described degradation process is reversible, after passivation removal and subsequent annealing. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Quasicrystals and the birth of the atomic age (2022)

The first nuclear bomb explosion led to the formation of a novel form of matter, known as a quasicrystal, with an elemental composition that had never been seen before.
Order effect when comparing usability of two telehealth remote monitoring technology solutions (2018)

An experienced healthcare device evaluator collaborated with a human factors scientist to develop and conduct a usability test of two different telehealth remote monitoring solutions as part of a larger technology evaluation. Twenty-one participants used each of the telehealth platforms to capture and transmit data. Typically users of telehealth platforms capture and send their own data, however, we asked our participants to place a bag of sand on wirelessly connected scales to capture weight information and to place the wireless pulse oximeters on the healthcare device evaluator’s index finger to get blood oxygen saturation measurements. This protocol enabled participants to go through the processes required to capture and share representative data without providing any of their own personal health data. After using each solution to complete the same series of three tasks, participants filled out the System Usability Scale (SUS) questionnaire. We intended to compare SUS scores within-subjects, but discovered that the SUS scores for the second solution were not independent. In particular, the participants who used the system that was harder to use second produced SUS scores for that system that were significantly lower than the participants who rated that system first. We conclude that it may not be appropriate to use a within-subjects design if experimenters plan to compare the SUS scores for different systems.
Three-dimensional Imaging of Nano-Voids in Copper Interconnects using Incoherent Bright Field (IBF) Tomography (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006
Prognostizieren (1982)

Im Kreis der statistischen Tätigkeiten ist das Prognostizieren relativ neu. Zwar impliziert jede Theorie, zumindest indirekt, auch Zukunftsbehauptungen, und insofern ist das Prognostizieren so alt wie das Theorienbilden. Aber die Prognostik als selbständige statistische Methode kam erst im vorigen Jahrhundert auf. Als Methode der Wettervorhersage ist sie 1863, als Methode des wirtschaftlichen Prognostizierens zu Anfang dieses Jahrhunderts entstanden.
Classification of Uremic Toxins and Their Role in Kidney Failure (2021)

Advances in our understanding of uremic retention solutes, and improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and classification of uremic toxins. A consensus conference was held to develop recommendations for an updated definition and classification scheme on the basis of a holistic approach that incorporates physicochemical characteristics and dialytic removal patterns of uremic retention solutes and their linkage to clinical symptoms and outcomes. The major focus is on the removal of uremic retention solutes by hemodialysis. The identification of representative biomarkers for different classes of uremic retention solutes and their correlation to clinical symptoms and outcomes may facilitate personalized and targeted dialysis prescriptions to improve quality of life, morbidity, and mortality. Recommendations for areas of future research were also formulated, aimed at improving understanding of uremic solutes and improving outcomes in patients with CKD.
Binary DNA Nanostructures for Data Encryption (2012)

We present a simple and secure system for encrypting and decrypting information using DNA self-assembly. Binary data is encoded in the geometry of DNA nanostructures with two distinct conformations. Removing or leaving out a single component reduces these structures to an encrypted solution of ssDNA, whereas adding back this missing "decryption key" causes the spontaneous formation of the message through self-assembly, enabling rapid read out via gel electrophoresis. Applications include authentication, secure messaging, and barcoding.
Asymmetrien eines Ethernet-Systems und deren Auswirkungen auf die Störaussendung im automobilen Umfeld (2014)

Seit Jahren ist ein Zuwachs von elektronischen Komponenten im Fahrzeug zu beobachten. Der Wunsch nach mehr Komfort und Sicherheit trägt hier maßgeblich dazu bei. Um den Anforderungen gerecht zu werden, sind schnelle Übertragungssysteme im Fahrzeug erforderlich, die die großen Datenmengen verteilen und verarbeiten können. Ein solches System ist zum Beispiel Ethernet, mit dem periphere Komponenten mit hohen Datenraten vernetzt werden können. Eine spezielle Variante für den automobilen Einsatz stellt dabei das OABR-Ethernet (Open-Alliance-BroadR-Reach) dar. Dieses Kommunikationssystem nutzt eine bidirektionale Übertragungstechnik um 100MBit/s über eine ungeschirmte Zweidrahtleitung (UTP) zu übertragen. Eine weitere Besonderheit ist die Begrenzung des Nutzsignalspektrums durch einen Tiefpassfilter auf ca. 70MHz. Dadurch wird das Risiko einer Störung im UKW-Bereich minimiert. Der Einsatz dieses schnellen Übertragungssystems im Fahrzeug stellt jedoch eine große Herausforderung an die Elektromagnetische-Verträglichkeit (EMV) dar. Bereits kleine Asymmetrien im Übertragungspfad führen dazu, dass ein Teil des Nutzsignals (Gegentaktsignal) durch Modenkonversion in ein Störsignal (Gleichtaktstörung) umgewandelt wird - nachfolgend Modenkonversion genannt. Diese Gleichtaktstörungen können über die UTP-Leitung abstrahlen und zu Grenzwertüberschreitungen bei Störaussendungsmessungen führen. Jede Komponente im Übertragungspfad trägt maßgeblich zur Modenkonversion und somit zur Störaussendung bei. Diese Arbeit soll eine Übersicht über die Modenkonversion der einzelnen Elemente der physikalischen OABR-Schnittstelle geben. Diese Elemente sind im Einzelnen der Tiefpassfilter (LPF), die Common-Mode-Choke (CMC), die differentiellen Mikrostreifenleitungen (DML) sowie die Platinen- und In-Line-Stecker.
WebCat - Information integration for Web catalogs (1998)

An important part of the World Wide Web (Web) is organized as collections of HTML pages, interrelated by hyperlinks, and arranged in some kind of hierarchy.The problem that we address is that of automating the process of searching through several col1ections of HTML pages, in which pages are interrelated by hyperlinks and the collections have a common domain.In order to automate the search we integrate these collections.We are interested in only those collections for which the common domain can be organized according to some kind of hierarchy.In this thesis, we define such colIections as being Web catalogs and we present WebCat, a paradigm to integrate such Web catalogs.In addition, we present an implementation for this paradigm for the domain of clothing catalogs.Integrating information sources is a problem addressed by lnformation lntegration Systems (11s).In this thesis we argue that the present IIS have difficulties in integrating Web catalogs.The difficulties are created by the lack of query capability of Web catalogs and by the ownership of the Web catalogs.We overcome these problems by extracting the schema of the Web catalogs augmented with the attributes that we are interested in, then we integrate them and store them locally.Once the data is stored locally, it can be queried.Consequently a query works as follows: first we retrieve the records from the local database that satisfy the query criteria; then, for each record, we retrieve the associated HTML pages from the Web.The WebCat methodology can be divided into two distinct methods: first, a method for wrapper building for Web catalogs, and second, a method of integrating this information.We call this method Information lntegration with Semantics since it relies on our knowledge of the domain to which the Web catalogs belong.For building wrappers for Web catalogs, we use a novel technique; specifically, we use the WebOQL query language in the core of our wrappers.Without his guidance, this thesis would have not existed.I would also like to thank Professor Ken Sevcik, my second reader, not only for his valuable recommendations
Polarity of the Stator Permanent Magnets of the Magnetic-Geared Motor (2014)

Polarity of the Stator Permanent Magnets of the Magnetic-Geared Motor � ���
Parametric loudspeaker for speech signal based on the combination of amplitude and frequency modulations (2013)

A parametric loudspeaker has been used for audio guidance to a specific area because it has a sharper directivity compared with the conventional electrodynamic loudspeakers. The parametric loudspeaker emits an ultrasound as a carrier wave, which is modulated with an audio signal and has large-amplitude. An audible sound is reproduced by the modulated ultrasound with large-amplitude distorted by the nonlinearity on the air. The conventional modulations have been proposed as the amplitude modulation and the frequency modulation. In the sound quality, the amplitude modulation is superior to the frequency modulation. However, in the sound pressure level, the frequency modulation is superior to the amplitude modulation. In the present paper, we especially focus on that the parametric loudspeaker will emit the speech signals for the audio guidance. Therefore, we propose new modulation method based on the combination of amplitude and frequency modulations, which are specialized for speech signals. More specifically, we apply the amplitude and frequency modulations to the divided frequency bands of speech signals, respectively. In order to confirm the effectiveness of the proposed method, we carried out evaluation experiments. As a result of evaluation experiments, we confirmed the effectiveness of the proposed method compared with conventional methods.
Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial (2020)

EudraCT2013-002763-25.
pH-Triggered Au-fluorescent mesoporous silica nanoparticles for19F MR/fluorescent multimodal cancer cellular imaging (2013)

Novel pH-triggered nanoprobe were fabricated for (19)F MRI and fluorescence imaging (MRI-FI) of cancer cells. The biocompatibility, durability, high internalizing efficiency and pore architecture justify the Au-fluorescent mesoporous silica nanoparticles as ideal, highly sensitive and highly specific vectors for (19)F MRI and FI of cancer cells.
Effect of top leases: obstruction of title and related considerations (1978)

Top leases, defined as a subsequent oil and gas lease which covers one or more mineral interests and is subject to a valid, subsisting prior lease, are described in terms of their effect on issues involving title. Court cases in which obstruction has been charged have generally not held unless some hostile action was involved. Top leases along have not been held to be an obstruction, although there is some confusion over this issue. The author traces the history of legal arguments over third party leases and concludes that, under certain classification, there is some basis for recognizing the legal status of a top lease as an interest in the land. He notes that large oil companies object to top leasing because of interference with planned production scheduled.