gebhart/patrepeval huggingface dataset:
Molecular weight and subunit structure of yeast enolase (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular weight and subunit structure of yeast enolaseKenneth G. Mann, Francis J. Castellino, and Paul A. HargraveCite this: Biochemistry 1970, 9, 20, 4002–4007Publication Date (Print):September 29, 1970Publication History Published online1 May 2002Published inissue 29 September 1970https://pubs.acs.org/doi/10.1021/bi00822a020https://doi.org/10.1021/bi00822a020research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data from Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;We have assessed the combination of DC–CIK with S-1 plus cisplatin chemotherapy in advanced gastric cancer (AGC) and the role of mutational analysis of circulating tumor DNA (ctDNA) and T-cell receptor (TCR) repertoire in predicting clinical outcomes.&lt;/p&gt;Patients and Methods:&lt;p&gt;Consecutive patients (&lt;i&gt;n&lt;/i&gt; = 63) with AGC were allocated to treatment with S-1 alone, S-1 plus cisplatin, DC–CIK combined with S-1 or DC–CIK combined with S-1 plus cisplatin. The primary endpoints were progression-free survival (PFS) and overall survival (OS) at 1 year; the secondary endpoints were disease control rate and analysis of ctDNA and TCR repertoire.&lt;/p&gt;Results:&lt;p&gt;The DC–CIK infusions were well tolerated with no serious adverse events. The disease control rates (CR&lt;sup&gt;+&lt;/sup&gt;PR&lt;sup&gt;+&lt;/sup&gt;SD) were 5.6%, 33.3%, 47.1%, and 76.9% in the S-1 alone, the S-1 plus cisplatin, DC–CIK combined with S-1 and DC–CIK combined with the S-1 plus cisplatin groups, respectively (&lt;i&gt;P&lt;/i&gt; = 0.001). After adjusting for competing risk factors, treatment with DC-CIK combined with S-1 plus cisplatin was confirmed to be an independent predictor of PFS and OS (&lt;i&gt;P&lt;/i&gt; = 0.001). A decrease in the frequency and number of mutations in ctDNA was observed in 19 patients (63.3%) following the DC–CIK infusions. Decreased ctDNA mutational frequency and restored TCR repertoire were associated with improved PFS and OS (&lt;i&gt;P&lt;/i&gt; = 0.001).&lt;/p&gt;Conclusions:&lt;p&gt;DC–CIK combined with S-1 plus cisplatin provided a favorable PFS and OS in patients with AGC and the combination therapy was safe with tolerable toxicities. Clinical efficacy correlated with decreases in ctDNA mutational profiles and restored TCR repertoire.&lt;/p&gt;&lt;/div&gt;
Funktionelle Interaktion des Tumorsuppressors p16 mit dem Onkoprotein K-Ras im humanen Pankreaskarzinom (2015)

Hintergrund/Einleitung: Das humane Pankreaskarzinom zeichnet sich durch funktionelle Inaktivierung von p16INK4a (p16) und onkogene Aktivierung von K-ras aus. Wir haben p16 in Capan-1 Zellen reexprimiert (Capan-1/p16) und so Anoikisresistenz und Tumorigenität aufheben können. Erste Untersuchungen zum Mechanismus der Anoikisinduktion zeigten eine Verminderung des Onkoproteins K-Ras (K-Ras).
Vinyltitanium as an initiator for the polymerization of acetylene (2002)

Abstract The preparation of lustrous conducting polyacetylene films by the polymerization of acetylene with vinyltitanium species as initiators was studied. Organotitanium species were generated by the alkylation of titanium vinylcarbene complexes with tert ‐butyl chloride. Solid‐state 13 C NMR and IR analyses of the obtained polyacetylene indicated that polyacetylene with a trans configuration was produced. The use of titanocene(II) species Cp 2 Ti[P(OEt) 3 ] 2 and titanium vinylcarbene complexes for the preparation of polyacetylene films was also studied. The morphology of the films and the mechanisms of polymerization are discussed. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 2663–2669, 2002
Supplementary Methods and Materials and Figure Legends from FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth (2023)

&lt;p&gt;PDF file, 114KB, This section includes Supplemental Materials and Methods. It also contains the legends to Supplemental Figures 1-9.&lt;/p&gt;
Hydrogen-Air/Lead Battery Hybrid System for Vehicle Propulsion (1971)

The high energy density of a fuel cell battery and the peak current capability of a secondary battery are combined in the power plant of an electric car. The four‐seat vehicle weighs 2000 lb and is powered by a 7 kW (20 kW peak) d‐c motor. The 6 kW hydrogen‐air fuel cell battery is connected in parallel with a 4 kWhr lead battery (84V) ; 660 ft3 of hydrogen are stored in six lightweight cylinders (180 lb total weight) equivalent to 33 kWhr of actually available electric energy. The design of the fuel cell battery was aimed at very long life expectancy on intermittent duty, fast automatic starting and shutdown, reliable safety features, and use of available commercial accessories. The operation of the car is not more difficult than driving a conventional auto; the range is over 200 miles. The refilling of the hydrogen cylinders takes only a few minutes from a 2000 psig supply. The acceleration is similar to that of a small car with a combustion engine. Top speed is 55 mph.
Virtual Inertia Adaptive Control of a Doubly Fed Induction Generator (DFIG) Wind Power System with Hydrogen Energy Storage (2018)

This paper presents a doubly fed induction generator (DFIG) wind power system with hydrogen energy storage, with a focus on its virtual inertia adaptive control. Conventionally, a synchronous generator has a large inertia from its rotating rotor, and thus its kinetic energy can be used to damp out fluctuations from the grid. However, DFIGs do not provide such a mechanism as their rotor is disconnected with the power grid, owing to the use of back-to-back power converters between the two. In this paper, a hydrogen energy storage system is utilized to provide a virtual inertia so as to dampen the disturbances and support the grid’s stability. An analytical model is developed based on experimental data and test results show that: (1) the proposed method is effective in supporting the grid frequency; (2) the maximum power point tracking is achieved by implementing this proposed system; and, (3) the DFIG efficiency is improved. The developed system is technically viable and can be applied to medium and large wind power systems. The hydrogen energy storage is a clean and environmental-friendly technology, and can increase the renewable energy penetration in the power network.
Implementing fault-tolerance in real-time programs by automatic program transformations (2008)

We present a formal approach to implement fault-tolerance in real-time embedded systems. The initial fault-intolerant system consists of a set of independent periodic tasks scheduled onto a set of fail-silent processors connected by a reliable communication network. We transform the tasks such that, assuming the availability of an additional spare processor, the system tolerates one failure at a time (transient or permanent). Failure detection is implemented using heartbeating, and failure masking using checkpointing and rollback. These techniques are described and implemented by automatic program transformations on the tasks' programs. The proposed formal approach to fault-tolerance by program transformations highlights the benefits of separation of concerns. It allows us to establish correctness properties and to compute optimal values of parameters to minimize fault-tolerance overhead. We also present an implementation of our method, to demonstrate its feasibility and its efficiency.
Repair Of Photomasks With Focussed Ion Beams (1985)

The development of high-brightness liquid metal ion sources [1] has made it possible to produce focussed ion beams with submicrometer dimensions and moderate current density (about 1 A/cm<sup>2</sup>). Several classes of applications for focussed ion beam systems have been proposed including direct implantation, lithography, and micromachining. Though focussed ion beams have some unique and attractive properties, they are unlikely to replace mainstream lithography and broad-beam implantation technologies. For instance, for applications such as high-dose source-drain implantations, the writing rate would be limited to only a few thousand pixels per second, resulting in excessive writing times. On the other hand, for certain niche applications a focussed ion beam may be the method of choice. As an example, a custom wafer requiring threshold adjustment implants (10<sup>13</sup> cm<sup>-2</sup> and 1% coverage) could be processed in less than an hour and would require no mask generation or resist processing and exposure steps.
Recent developments in electrokinetically driven analysis on microfabricated devices (2000)

This review is devoted to the rapid developments in the field of microfluidic separation devices in which the flow is electrokinetically driven, and where the separation element forms the heart of the system, in order to give an overview of the trends of the last three years. Examples of microchip layouts that were designed for various application areas are given. Optimization of mixing and injection strategies, designs for the handling of multiple samples, and capillary array systems show the enormous progress made since the first proof-of-concept papers about lab-on-a-chip devices. Examples of functional elements for on-chip preconcentration, filtering, DNA amplification and on-chip detection indicate that the real integration of various analytical tasks on a single microchip is coming into reach. The use of materials other than glass, such as poly(dimethylsiloxane) and polymethylmethacrylate, for chip fabrication and detection methods other than laser-induced fluorescence (LIF) detection, such as mass spectrometry and electrochemical detection, are described. Furthermore, it can be observed that the separation modes known from capillary electrophoresis (CE) in fused-silica capillaries can be easily transferred to the microchip platform. The review concludes with an overview of applications of microchip CE and with a brief outlook.
Outcomes of microincision vitrectomy surgery with internal limiting membrane peeling for macular edema secondary to branch retinal vein occlusion (2015)

MIVS with ILM peeling for macular edema secondary to BRVO is effective in improving visual acuity and foveal morphology with low recurrence of macular edema.
Dutch Holographic Laboratory (1995)

My company, Dutch Holographic Laboratory B.V. (DHL), first received international recognition with Microscope in 1984. This image of a microscope protrudes more than 9 inches in front of the holographic plate. When viewers look into the microscope's illusory eyepiece, they see the actual magnification of a computer chip, just as if the microscope really existed. This 8-x-10-in reflection hologram has opened viewers' eyes to a new perception of holographic imaging and spawned a number of offshoots (Fig. 1). DHL's laboratories, which include high-tech laser systems, are dedicated to ongoing research and development in holography. Apart from the lasers and optics, all the equipment is custom-fabricated in house and includes four vibration-isola-
A 30-dBm Class-D Power Amplifier with On/Off Logic for an Integrated Tri-Phasing Transmitter in 28-nm CMOS (2018)

This paper presents an eight-unit class-D power amplifier (PA), implemented in 28-nm CMOS. The PA is designed to utilize tri-phasing modulation, which combines coarse-amplitude polar modulation with fine-resolution outphasing components. This new technique enables achieving the back-off efficiency of multilevel outphasing without linearity-degrading discontinuities in the output waveform. Each PA unit contains a cascoded output stage with a 3.6-V supply voltage, and on/off logic enabling multilevel operation controlled by low-voltage signals. The PA achieves a peak output power of 29.7 dBm with a 34.7% efficiency, and is verified to operate with aggregated LTE signals at bandwidths up to 60 MHz at 1.7-GHz carrier frequency.
Electron Paramagnetic Resonance and Electron-Nuclear Double Resonance Studies of the Reactions of Cryogenerated Hydroperoxoferric–Hemoprotein Intermediates (2014)

The fleeting ferric peroxo and hydroperoxo intermediates of dioxygen activation by hemoproteins can be readily trapped and characterized during cryoradiolytic reduction of ferrous hemoprotein-O2 complexes at 77 K. Previous cryoannealing studies suggested that the relaxation of cryogenerated hydroperoxoferric intermediates of myoglobin (Mb), hemoglobin, and horseradish peroxidase (HRP), either trapped directly at 77 K or generated by cryoannealing of a trapped peroxo-ferric state, proceeds through dissociation of bound H2O2 and formation of the ferric heme without formation of the ferryl porphyrin π-cation radical intermediate, compound I (Cpd I). Herein we have reinvestigated the mechanism of decays of the cryogenerated hydroperoxyferric intermediates of α- and β-chains of human hemoglobin, HRP, and chloroperoxidase (CPO). The latter two proteins are well-known to form spectroscopically detectable quasistable Cpds I. Peroxoferric intermediates are trapped during 77 K cryoreduction of oxy Mb, α-chains, and β-chains of human hemoglobin and CPO. They convert into hydroperoxoferric intermediates during annealing at temperatures above 160 K. The hydroperoxoferric intermediate of HRP is trapped directly at 77 K. All studied hydroperoxoferric intermediates decay with measurable rates at temperatures above 170 K with appreciable solvent kinetic isotope effects. The hydroperoxoferric intermediate of β-chains converts to the S = 3/2 Cpd I, which in turn decays to an electron paramagnetic resonance (EPR)-silent product at temperature above 220 K. For all the other hemoproteins studied, cryoannealing of the hydroperoxo intermediate directly yields an EPR-silent majority product. In each case, a second follow-up 77 K γ-irradiation of the annealed samples yields low-spin EPR signals characteristic of cryoreduced ferrylheme (compound II, Cpd II). This indicates that in general the hydroperoxoferric intermediates relax to Cpd I during cryoanealing at low temperatures, but when this state is not captured by reaction with a bound substrate, it is reduced to Cpd II by redox-active products of radiolysis.
Virus government – A twenty-first-century genealogy of the ‘Dusk mask’ as biopolitical technology (2021)

This essay provides a genealogy of the recent operations of ‘virus government’ in the United States which followed the early twenty-first-century governmental discourse about and technologization of Homeland Security and a War on Terror. Through the genealogy, the essay asks what has and has not changed during the last twenty years of governmental and biopolitical response to public safety and social security as a personal responsibility. To understand and rethink that history, the essay proposes the usefulness of considering the COVID mask as a technology of virus government and as a Liberal object.
DNA compaction and dynamic observation in a nanopore gated sub-attoliter silicon nanocavity (2022)

Confinement of biopolymers inside volumes with micro- or nanoscale lateral dimensions is ubiquitous in nature. Investigating the behavior of biopolymers in a confined environment is essential to improve our basic understanding in life sciences. In this work, we present a nanopore gated sub-attoliter silicon nanocavity device, which allows DNA compaction similar to that in virus capsids. Single DNA molecules can be electrically driven into the nanocavity, and then get compacted inside the nanocavity under certain conditions. The dynamic fluctuations of the compacted DNA can be monitored <i>via</i> ionic current measurements. The mechanism for the DNA compaction is elucidated by varying the DNA length or concentration, voltage polarity, nanocavity dimensions and ionic strength. Furthermore, Brownian dynamics simulations reveal the dynamic fluctuations of the compacted DNA, which are reflected in the measured ionic current. Our nanocavity device is anticipated to provide a controlled environment in extremely small volumes for investigating the physics of confined biopolymers.
Inelastic scattering of 160 MeV protons byCa48 (1984)

Differential cross sections and analyzing powers were measured for the inelastic scattering of 160-MeV polarized protons over the angular range ${6}^{\ensuremath{\circ}}\ensuremath{\le}\ensuremath{\theta}\ensuremath{\le}{49.5}^{\ensuremath{\circ}}$. The spectra covered excitation energies up to about 11 MeV in $^{48}\mathrm{Ca}$. Angular distributions and analyzing powers were determined for 28 separate peaks. The data are compared to distorted-wave impulse approximation calculations and spin assignments are suggested for many of the states. The resulting level diagram is compared to three different shell model calculations of the $^{48}\mathrm{Ca}$ spectrum.
Computer Aided Measurement Techniques for Integrated Optic Devices (1986)

Computer aided measurement systems for the determination of nearfield intensity profiles, insertion loss, waveguide attenuation by Fabry-Perot resonance and refractive index profiles by effective indices have been developed. The repeatability and accuracy of the measurements have been analyzed.
Our Journey Beyond Sunset Boulevard: Evidence-Based Analysis of Tumor-Targeted Cancer Gene Therapy Shines a Critical Spotlight on Long-Term Cancer-Free Survival (2021)

This unique “PERSPECTIVE” on Targeted Genetic Medicine for Cancer represents the third manuscript in a series of medical oncology papers by gene therapy pioneers, Gordon and Hall, a combined medical oncologist’s and layman’s trilogy recorded with the following intents and purposes: (i) documenting significant milestones in clinical oncology for the medical community, (ii) honoring forthright principles of “Informed Consent” for the advanced/refractory oncology patient, and (iii) confronting logical fallacies of popular opinion, in light of recent critical analyses of long-term cancer-free survival data. As with the two previous historical “perspectives,” the authors present noteworthy up-to-date clinical research documenting the successful management of refractory metastatic cancers with tumor-targeted gene therapy vectors—validating “Pathotropic” (disease-seeking) tumor targeting Avant la Lettre. This paper provides additional insights into the molecular and cellular mechanisms of both tumor-targeting and tumor-eradication. As with the prior two papers, the authors utilize the revealing powers of allegory and classic literature, adding shared iconic cinematic experiences of postmodernism at times, to educate, inform, and convey the formidable yet verifiable and important hard-core science (that is, the fundamental chemistries, biophysics, molecular biology, genetics, stem cell biology, regulatory biology, synthetic virology, tumor immunology, clinical oncology, bio-pharmacology, histopathology, and cancer gene therapy) embodied within the “smart” therapeutic nanoparticle, DeltaRex-G: a refined “primal-hunter” &amp; “tumor-killer” that actively seeks out the cryptic/hidden “Biochemical (Jailbreak) Signatures” of metastatic cancers, delivers targeted gene therapy “precisely”totumor cells, and ultimately eradicates both primary and metastatic lesions, including lymphatic metastases. Accomplishment of the “DeltaRex-G Rescue-Mission of 2019” with updated FDA regulatory approvals and sustainable/scalable cGMP bioproduction is considered opportune—while the Right-to-Try experimental therapies legislation in the United States comes face-to-face with the U.S. FDA approval of Expanded Access for DeltaRex-G for advanced pancreatic cancer and sarcoma, and compassionate use for all solid tumors—as such, the authors embrace the legitimate rights of the cancer patient to be more fully informed of such beneficial treatments currently available in the United States.
Development of a Subsystem for Supporting a Complex of Diagnostic Procedures for the Information-Analytical System TISP (2021)

Introduction. During the implementation of the project "Transdisciplinary Intelligent Information-Analytical System for Supporting Rehabilitation Processes in a Pandemic (TISP)", all the capabilities of the basic cognitive information technology were focused on the implementation of the strategy of rehabilitation measures, which consists in taking into account the pathogenetic features of the development of the disease. In the subsystem of information and analytical support of the complex of diagnostic procedures, the central is the assessment of the effectiveness of rehabilitation based on the indicators of the electrocardiogram (ECG) and heart rate variability (HRV), control of the patient's condition using psychophysiological (PF) and psychological testing, the use of biological feedback (BF) to improve the efficiency of rehabilitation, as well as the use of PF testing for the implementation of BF. The purpose of the article is detailing the composition and functionality of a complex of diagnostic procedures for supporting rehabilitation processes in a pandemic. Results. The composition and functionality of the complex of diagnostic procedures are presented. It includes three components: first, an innovative technique for scaling electrocardiograms and heart rate variability (Universal Scoring System) with software and a miniature electrocardiograph (with the ability to use on-line mode). Secondly, the study of psychophysiological testing tools based on the software-hardware complex "Psykholot-1" with the prospect of its addition by means of Biological Feedback (BF). Thirdly, the analysis of existing means of BF therapy and their application for rehabilitation with the proposed method of rehabilitation based on BF using artificial intelligence tools that are being developed within the framework of this project. In the future, it is planned to monitor patients undergoing rehabilitation in order to develop new rules specially adapted for assessing and monitoring the current state of patients undergoing rehabilitation, as well as the effectiveness of BF for rehabilitation. To implement the BF, the Psykholot-1 complex should be used in a trainer mode with a visual presentation of PF tests to the patient in real time. Conclusions. Hardware and software systems of biomanagement must be present at every workplace of a doctor, psychologist, coach, teacher. They can not only help in the treatment of patients, but also can change motivation, mobilize personal resources, and this is what many of us lack today. Keywords: rehabilitation, diagnosis, psychophysiological testing, electrocardiogram, heart rate variability, biological feedback.