gebhart/patrepeval huggingface dataset:
TIP60 mediated regulation of ΔNp63α is associated with Cisplatin resistance (2022)

About 5.4 million basal and squamous cell skin cancers are diagnosed each year in the US. Cisplatin, a chemotherapeutic drug is often used to treat squamous cell carcinoma (SCC) patients. However, 55% of cancers fail to respond leading to lower response rates and higher rates of disease re‐occurrence. ΔNp63α a member of the p53 transcription factor family is overexpressed and considered oncogenic in non‐melanoma skin cancer where it regulates cell survival and proliferation. TIP60 (Tat‐interacting protein 60kDa), a histone acetyltransferase has been shown to mediate cellular processes such as transcription regulation and the DNA damage response (DDR). We recently reported that TIP60 positively regulates ΔNp63α protein levels in a catalytic‐dependent manner to promote SCC proliferation. Since ΔNp63α is known to transcriptionally regulate several DDR genes and promote resistance to cisplatin, its stabilization by TIP60 may contribute to the failure of platinum‐based drugs in SCC. We hypothesis that TIP60 mediated acetylation of ΔNp63α regulates its transcriptional activity thereby modulates chemoresistance. In this study, we showed that silencing of endogenous TIP60 in multiple SCC cell lines led to decrease in ΔNp63α transcript and protein levels confirming that TIP60 positively regulates ΔNp63α. Increased levels of TIP60 positively correlated with increased ΔNp63α expression and contributes to cisplatin resistance. Further, stable expression of TIP60 or ΔNp63α individually promoted resistance to cisplatin and reduced cell death, whereas loss of ΔNp63α and TIP60 sensitized cells to cisplatin. Higher acetylation of ΔNp63α and TIP60 were seen in cisplatin resistant cell line. Taken together, our data suggest that TIP60‐mediated stabilization of ΔNp63α increases cisplatin resistance and has potential implication for SCC cancer treatment and drug design. Additionally, since ΔNp63α confers cisplatin resistance through regulation of genes involved in DNA damage repair, our findings provide critical insights into the mechanism by which genes involved in chemoresistance are regulated and may lead to strategic treatment for resistant SCC tumors and other epithelial cancers with increased efficacy.
Highlights from this issue (2019)

Choriocapillaris and retinal vascular plexus density of diabetic eyes using Split-spectrum Amplitude-Decorrelation spectral domain optical coherence tomography angiography (see page 452) Capillary perfusion density in Choriocapillaris and retinal vascular plexuses in diabetic patients were observed in association with worsening retinopathy in comparison with healthy eyes using split-spectrum amplitude decorrelation spectral domain optical coherence tomography angiography. Possible connection of short posterior ciliary arteries to choroidal Neovascularization in eyes with pathologic myopia (see page 457)Residual blood flow was detected in eyes with Myopic choroidal neovascularization (mCNV) retained detectable blood flow even in the atrophic phase on Optical Coherence Tomography (OCT) angiography.OCT B scans and Indocyanine Green Angiography revealed that the mCNVs were continuous with scleral branches of the short posterior ciliary arteries.
Calculation of end-winding forces of inverter fed drives (2012)

End-winding forces can be approximated applying the Biot-Savart law. Usually constant speed and ideal sinusoidal currents are assumed. Applying these constrains a simulation of the forces for one electrical period is sufficient. However, for inverter fed drives, the harmonic content of the current is dependent on the operational load and speed. In this case the forces for each time step of the drive cycle of traction drive have to be calculated individually. This paper proposes a superposition of so called unit-current forces for each current harmonic. Still, the forces are calculated for one electrical period with unit-current amplitude based on Biot-Savarts law. The calculation of the resulting forces is performed by means of a current superposition. This allows for a computational cost effective simulation of end-winding forces taking current harmonics due to inverter supply, speed and load dynamic operations into account. Streszczenie. Sily w polączeniach czolowych mogą byz wyznaczane przy uzyciu prawa Biota-Savarta. Zwykle przyjmuje sie stalą predkośc obwodową i sinusoidalny przebieg prądu. Te zalozenia są wystarczające dla symulacji sil w jednym okresie elektrycznym. Jednakze w sytuacji gdy naped zasilany jest przeksztaltnika i wystepują zalezne od obciązenia i predkości harmoniczne sily muszą byc obliczane indywidualnie dla kazdego kroku czasowego w cyklu trakcyjnym. W artykule proponowana jest metoda superpozycji sil od jednostkowych prądow dla kazdej harmonicznej prądu. Wowczas sily mogą byc, podobnie jak dla przebiegow sinusoidalnych, obliczane w jednym okresie elektrycznym z wykorzystaniem prawa Biota-Savarta. Obliczanie sily wypadkowej wykonywane jest poprzez superpozycje prądow. Procedura taka pozwala na uwzglednienia predkości i obciązenia w obliczeniach sil w polączeniach czolowych. (Obliczenia sil w polączeniach czolowych napedow zasilanych z przeksztaltnika).
Distribution of Rht Genes in Modern and Historic Winter Wheat Cultivars from the Eastern and Central USA (2010)

ABSTRACT Over 70% of wheat ( Triticum aestivum L.) cultivars grown worldwide have a semidwarf phenotype controlled by the major genes Rht‐B1, Rht‐D1 , and Rht8c The objective of this study was to determine their frequency in a set of historic and modern soft and hard winter wheat cultivars grown in the central and eastern USA. Three hundred sixty‐two cultivars that were developed from 1808 to 2008 were evaluated with molecular markers for Rht‐B1 , Rht‐D1 , and Rht8c All cultivars released before 1964 (41 soft winter wheat and 6 hard winter wheat) had wild‐type (tall) alleles at all three loci. After introduction of the dwarfing genes, the percentage of tested lines carrying either Rht‐B1b or Rht‐D1b increased rapidly to greater than 90% of modern varieties. Among soft winter wheat cultivars, the Rht‐D1b dwarfing gene was the most frequent being present in 45% of all lines tested and Rht‐B1b was present in 28%, while in the hard winter wheat cultivars the Rht‐B1b allele is the most prevalent in 77% of lines. Only 8% of the hard cultivars tested had the Rht‐D1b allele. The presence of the 192‐base pair (bp) allele of the microsatellite marker Xgwm261 indicated that Rht8c was less frequently used as a source of dwarfing in U.S. winter wheat germplasm, being present in 8 and 3% of the soft winter wheat and the hard winter wheats, respectively. A number of modern cultivars were identified that did not carry any of the dwarfing genes assayed and may possess alternative reduced height genes.
Modeling, design and demonstration of ultra-short and ultra-fine pitch metastable Cu-Sn interconnections with high-throughput SLID assembly (2015)

Advances in high-performance package with high I/O densities, and power modules with escalating current needs are driving the need for a new class of interconnection technologies, with thermal stability, current-carrying capability and pitch scalability beyond that of traditional solders. Solid-liquid interdiffusion (SLID or SoLID) or transient liquid phase (TLP) bonding systems, in which the bonding layer is fully converted to intermetallics, are highly sought after to extend the applicability of solders to pitches below 30μm, and for die-attachment in high-temperature high-power systems. This paper introduces an innovative SLID concept, consisting of isolating a metastable intermetallic phase between barrier layers for a faster conversion to metastable composition than that in traditional SLID. The Cu-Sn system was used for this demonstration with a designed transition to metastable Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> instead of the stable Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn phase, usually targeted. The novel interconnection structure enables assembly within seconds and improved thermomechanical reliability, with all the benefits of SLID bonding such as outstanding thermal stability over 10x reflow and enhanced power handling capability with a current density of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The paper first describes the design and fabrication of the interconnection structure, including the barrier and bonding layers based on diffusion and thermomechanical modeling. Ultra-fast assembly by low-pressure thermocompression bonding was demonstrated on die-attach joints and interconnections at 100μm pitch, followed by extensive reliability characterization, including thermal stability evaluation, electromigration test, and die-shear test. The designed interconnections successfully passed JEDEC standards, qualifying this novel interconnection technology for high-temperature, high-power operations at fine-pitch.
The effect of placement and light conditions during foliar application of Insol U fertilizer on gas exchange, yield and the quality of spinach (Spinacia oleracea L.) (2009)

Abstract Pot experiments conducted in a growth chamber studied the effectiveness of foliar fertilization of spinach (Spinacia oleracea L.) with macro- and microelements in the form of a 1% water solution of Insol U fertilizer applied with fluorescent light of the PAR intensity of 200 μmol m -2 s -1 and with dispersed daylight of the intensity of 600 μmol m -2 s -1 . Insol U was applied three times, supplied on the upper, lower or both sides of the leaf blades. The control consisted of plants sprayed with distilled water. The obtained results pointed out that foliar fertilization of spinach with Insol U significantly increased the leaf gas exchange, the yield of the fresh leaf mass, the content of vitamin C, chlorophyll, carotenoids, as well as potassium and phosphorus in the leaves. The application of the fertilizer onto the upper and the lower side of the leaf blade had the most positive effect on the analysed property of the leaves. Independently of the side leaf, the application of the fertilizer at a higher light intensity had a significantly better consecutive effect on all the analysed properties of the leaves.
A convolution model for computing the far-field directivity of a parametric loudspeaker array (2015)

This paper describes a method to compute the far-field directivity of a parametric loudspeaker array (PLA), whereby the steerable parametric loudspeaker can be implemented when phased array techniques are applied. The convolution of the product directivity and the Westervelt's directivity is suggested, substituting for the past practice of using the product directivity only. Computed directivity of a PLA using the proposed convolution model achieves significant improvement in agreement to measured directivity at a negligible computational cost.
The Influence of St. John's Wort on the Pharmacokinetics and Protein Binding of Imatinib Mesylate (2004)

Coadministration of imatinib with St. John's wort may compromise imatinib's clinical efficacy.
Kinetics of the Oxidation of Chromium (1957)

The oxidation of high purity chromium was studied over the temperature range 700°–1100°C using the vacuum microbalance method. Below 900°C conventional oxidation curves were obtained which can be fitted to the parabolic rate law. Above 900°C and for a film thickness of approximately 4800Aå, the rate of oxidation increased in an unusual manner. This increase in the rate of oxidation disappeared on further oxidation. At temperatures of 1050°C and higher a large increase occurred in the rate of oxidation, suggesting that the oxide film was no longer protective for film thicknesses greater than 42,000Aå.
Multiline Operation from a Single Plasmon-Assisted Laser (2017)

The demonstration of plasmon-assisted lasing by associating optical gain media with plasmonic nanostructures has led to a new generation of nanophotonic devices with unprecedented performances. However, despite the variety of designs demonstrated so far, the operation of these systems is in most cases limited to a single output wavelength, and some reports on multiline emission refer to mixing single nanolasers with the subsequent limitation in compactness. Here, we show multiline operation from a single plasmon-assisted nonlinear solid-state laser on which a linear chain of Ag nanoparticles is deposited. The system provides lasing at 1.08 μm, which is self-converted to the visible range through different parametric frequency-mixing processes generated at metal-dielectric interfaces. Near infrared and simultaneously green and tunable blue radiation with a subwavelength confinement in the direction perpendicular to the nanoparticle chain, are obtained at room temperature in CW regime. The results demonstrate the possibility of multifunctional operation from a single plasmon-assisted laser and offer new avenues for the development of highly integrable sources of coherent radiation.
Quantitative perfusion measurements using pulsed arterial spin labeling: Effects of large region‐of‐interest analysis (2005)

Analysis of ASL data based on a large ROI may suffer from inaccuracies arising from a distribution of transit times, implying that averaging of ASL kinetic data over such regions should therefore be avoided. When possible, a PBP fit should be performed.
Analysis of Processing Contaminants in Edible Oils. Part 2. Liquid Chromatography–Tandem Mass Spectrometry Method for the Direct Detection of 3-Monochloropropanediol and 2-Monochloropropanediol Diesters (2013)

A method was developed and validated for the detection of fatty acid diesters of 2-monochloropropanediol (2-MCPD) and 3-monochloropropanediol (3-MCPD) in edible oils. These analytes are potentially carcinogenic chemical contaminants formed during edible oil processing. After separation from oil matrices using a two-step solid-phase extraction (SPE) procedure, the target compounds are quantitated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization (ESI). The first chromatographic conditions have been developed that separate intact diesters of 2-MCPD and 3-MCPD, allowing for their individual quantitation. The method has been validated for 28 3-MCPD diesters of lauric, myristic, palmitic, linolenic, linoleic, oleic, and stearic acids in coconut, olive, and palm oils, as well as 3 2-MCPD diesters, using an external calibration curve. The range of average recoveries and relative standard deviations (RSDs) across the three oil matrices at three spiking concentrations are 88-118% (2-16% RSD) with maximum limits of quantitation of 30 ng/g (ppb).
Theoretical investigation of electronic and molecular structures of bithiopyranylidene and related conducting complexes (1984)

Electronic structures of bipyranylidene (BIPO)and bithiopyranylidene (BIPS) have been investigated by means of ab initio theoretical calculations. Evolution of the molecular structures of bithiopyranylidene and related compounds upon substitution and doping with electron acceptors (iodine, TCNQ)are explained on the basis of Molecular Orbital theory.
Obsessive-compulsive disorder with psychotic features: a phenomenologic analysis (1986)

The authors review the literature on obsessive-compulsive disorder and present clinical vignettes to illustrate that delusions can arise in the course of this illness. These delusions do not signify a schizophrenic diagnosis but represent reactive affective or paranoid psychoses, which are generally transient. Using a phenomenologic analysis of 23 patients, the authors further argue that obsessive-compulsive disorder represents a psychopathological spectrum varying along a continuum of insight. Patients at the severe end of this spectrum are best described as having an "obsessive-compulsive psychosis." The authors discuss the implications of these considerations for DSM-III revisions.
Photoperception cellulaire et protéines photoactives (2007)

National audience
Surface Acoustic Wave Devices (1999)

Abstract A surface‐acoustic‐wave (SAW) device employs an acoustic wave guided along the surface of a piezoelectric crystal, in which the stresses and strains of the wave are coupled to electric fields. The wave has a low velocity, typically 3500 m/s, and propagates with low attenuation. These features enable compact low‐loss devices to be developed for electronics applications at frequencies up to several GHz. Arrays of metal electrodes are used to generate, detect or reflect the waves. This technology has enormous versatility because standard lithographic techniques can be used to fabricate almost arbitrary geometries. This article summarises the nature of surface waves and some relevant propagation effects, including diffraction. The interdigital transducer, used in all these devices for wave generation, is described. A survey of suitable materials is given, including quartz, lithium niobate and lithium tantalate. Transversal bandpass filters are weighted using apodisation or withdrawal weighting. They are widely used in TV receivers, as well as in professional equipment which calls for very high performance devices. For radar, SAW pulse compression filters perform a correlation operation, increasing the range capability. Other devices perform correlation for spread‐spectrum communication waveforms, an example being the SAW non‐linear convolver which is capable of instantaneous programmability. For mobile telephony there has been a strong demand for miniature low‐loss bandpass filters, and a wide variety of novel SAW devices have been developed. For example, impedance element filters give 1 dB loss at 900 MHz, with 30 MHz bandwidth and a package size of 2 × 2 mm 2 . For IF filtering in the CDMA mobile phone system, a modified type of transversal filter called the R‐SPUDT enables both low loss and small size to be obtained. For GSM IF circuits, transverse‐coupled resonator filters have been developed to give a very narrow bandwidth of 200 kHz. The article concludes with a superficial survey of the theory of these devices. Introduction Interdigital Transducers Propagation Effects Materials Basic SAW Filters Low‐Loss Bandpass Filters Leaky Surface Waves Analysis Methods
Expression of Multidrug Resistance Associated Protein 5 (MRP5) on Cornea and Its Role in Drug Efflux (2009)

Taken together immunolocalization on human cornea, in vitro efflux in human, rabbit corneal and MRP5 over expressing cells, ex vivo and in vivo studies in intact rabbit cornea suggest that MRP5 on cornea can significantly lower the permeability of antiviral and glaucoma drugs. These findings may be valuable in developing formulation strategies to optimize ocular bioavailability of topically administered ocular agents.
Real-time qPCR as a tool for evaluating RNAi-mediated gene silencing (2008)

This article describes how rt-qPCR can be implemented as a tool to monitor silencing efficiency and functional effects of RNA interference (RNAi)-mediated gene knockdown, using examples from our research on neuroblastoma.
Anatomie resection for severe blunt liver trauma in 100 patients: Significant differences between young and elderly (2002)

The liver is the organ most commonly injured during blunt abdominal trauma. As our society ages, emergency surgery for active elderly patients increases, but data on aggressive emergency hepatic resection remain scarce in the literature. The purpose of this study was to determine whether the elderly (70 years of age or older) can tolerate major liver injury and subsequent hepatic resection. We investigated 100 patients who were treated by an anatomic resection for severe blunt liver trauma (29 elderly patients who were 70 years of age or older and 71 young patients who were younger than 70 years of age) in a retrospective study. The elderly patients were more severely injured as demonstrated by a higher Injury Severity Score, a lower Glascow Coma Scale, and lower survival (80.3% vs. 65.5%; p < 0.05). The total number of associated injuries was greater in elderly patients. Motor vehicle accidents were responsible for 71.8% of the injuries in the young group, and the predominant mechanism in the elderly patients was also motor vehicle accidents (51.7%). The 71 anatomic hepatic resections performed on the young patients included right hemihepatectomy (n = 45), left lateral segment resection (n = 14), bisegmentectomy (n = 5), and others. The 29 anatomic hepatic resections performed for the elderly patients were right hemihepatectomy (n = 15), left lateral segment resection (n = 5), left hemihepatectomy (n = 4), and others. Pneumonia, subphrenic abscess, and urosepsis occurred at a significantly higher frequency in elderly patients than in young patients. Our data clearly indicated that (1) the mechanism of injury, grade of associated intraabdominal injuries, distribution of surgical procedures, and complications differ significantly between young and elderly patients; and (2) the survival rate (65.5%) in elderly patients may be sufficient to consider anatomic hepatic resection to be a useful, safe procedure.
Immunization and Hedging of Post Retirement Income Annuity Products (2017)

Designing post retirement benefits requires access to appropriate investment instruments to manage the interest rate and longevity risks. Post retirement benefits are increasingly taken as a form of income benefit, either as a pension or an annuity. Pension funds and life insurers offer annuities generating long term liabilities linked to longevity. Risk management of life annuity portfolios for interest rate risks is well developed but the incorporation of longevity risk has received limited attention. We develop an immunization approach and a delta-gamma based hedging approach to manage the risks of adverse portfolio surplus using stochastic models for mortality and interest rates. We compare and assess the immunization and hedge effectiveness of fixed-income coupon bonds, annuity bonds, as well as longevity bonds, using simulations of the portfolio surplus for an annuity portfolio and a range of risk measures including value-at-risk. We show how fixed-income annuity bonds can more effectively match cash flows and provide additional hedge effectiveness over coupon bonds. Longevity bonds, including deferred longevity bonds, reduce risk significantly compared to coupon and annuity bonds, reflecting the long duration of the typical life annuity and the exposure to longevity risk. Longevity bonds are shown to be effective in immunizing surplus over short and long horizons. Delta gamma hedging is generally only effective over short horizons. The results of the paper have implications for how providers of post retirement income benefit streams can manage risks in demanding conditions where innovation in investment markets can support new products and increase the product range.