gebhart/patrepeval huggingface dataset:
Enantioselective Synthesis of α-Quaternary Mannich Adducts by Palladium-Catalyzed Allylic Alkylation: Total Synthesis of (+)-Sibirinine (2015)

A catalytic enantioselective method for the synthesis of α-quaternary Mannich-type products is reported. The two-step sequence of (1) Mannich reaction followed by (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in effect access asymmetric Mannich-type products of "thermodynamic" enolates of substrates possessing additional enolizable positions and acidic protons. Palladium-catalyzed decarboxylative allylic alkylation enables the enantioselective synthesis of five-, six-, and seven-membered ketone, lactam, and other heterocyclic systems. The mild reaction conditions are notable given the acidic free N-H groups and high functional group tolerance in each of the substrates. The utility of this method is highlighted in the first total synthesis of (+)-sibirinine.
Adsorption/membrane filtration as a contaminant concentration and separation process for mixed wastes and tank wastes. Progress report, 1996--1997 (1997)

'The goal of this research is the development of a treatment system for the separation of contaminants in low-organic Hanford tank wastes into sub-groups that can subsequently be processed and appropriately disposed of. Since many of the contaminants of concern are associated with solids, initial experimental work has focused on characterizing the particulate matter in Hanford waste and understanding the filterability of this waste through membranes. Removal of some of the soluble contaminants by adsorption has been studied as well. The experimental work conducted to date can be divided into four categories: speciation calculations; solid/aqueous phase partitioning; membrane filtration experiments; and sorption experiments. The work was conducted using two simulated Hanford wastes (SHWs), one that contained strong complexing agents (citrate and EDTA) and one that did not.'
Maturation of Cutaneous Sensory Neurons From Normal and NGF-Overexpressing Mice (2000)

In the rodent, cutaneous sensory neurons mature over the first two postnatal weeks, both in terms of their electrical properties and their responses to mechanical stimulation of the skin. To examine the coincidence of these events, intracellular recordings were made from neurons in the dorsal root ganglion (DRG) in an in vitro spinal cord, DRG, and skin preparation from mice between the ages of postnatal day 0 and 5 (P0-P5). We also examined mice in which nerve growth factor (NGF) is overexpressed in the skin. NGF has been shown to be involved in a number of aspects of sensory neuron development and function. Therefore we ask here whether excess target-derived NGF will alter the normal course of development, either of somal membrane properties, physiological response properties, or neuropeptide content. In wild-type mice, somal action potentials (APs) were heterogeneous, with some having simple, uninflected falling phases and some displaying an inflection or break on the falling limb. The proportion of neurons lacking an inflection increased with increasing age, as did mean conduction velocity. A variety of rapidly and slowly adapting responses could be obtained by gently probing the skin; however, due to relatively low thresholds and firing frequencies, as well as lack of mature peripheral receptors such as hairs, it was not possible to place afferents into the same categories as in the adult. No correlation was seen between the presence or absence of an inflection on the somal AP (a marker for high-threshold mechanoreceptors in adult animals) and either peripheral threshold or calcitonin-gene related peptide (CGRP) content. Small differences in the duration and amplitude of the somal AP were seen in the NGF-overexpressing mice that disappeared by P3-P5. Excess target-derived NGF did not alter physiological response properties or the types of neurons containing CGRP. The changes that did occur, including a loss of the normal relationship between AP duration and conduction velocity, and a decrease in mean conduction velocity in the inflected population, might best be explained by an increase in the relative proportions of myelinated nociceptors. Of greatest interest was the finding that in both NGF overexpressers and wild-type mice, the correlation between mechanical threshold and presence or absence of an inflection on the somal spike is not apparent by P5.
C-reactive Protein and Risk of Colorectal Adenomas or Serrated Polyps: A Prospective Study (2014)

Serum C-reactive protein (CRP) is a sensitive marker of systemic inflammation. Because there is a well-recognized relationship between local inflammation and colorectal cancer, we aimed to evaluate whether serum CRP levels were associated with the occurrence of colorectal adenomas and serrated polyps using data from a large adenoma prevention trial. A total of 930 participants with a history of colorectal adenomas were enrolled in a randomized trial of calcium supplementation (1,200 mg/day) for the prevention of colorectal adenomas. Outcomes in this analysis are metachronous adenomas (and advanced neoplasms specifically), and serrated polyps at follow-up colonoscopy. High-sensitivity CRP levels were measured 1 year following baseline colonoscopy. Multivariate analysis was performed to estimate risk ratios (RR) using Poisson regression, controlling for potential confounders. We measured serum CRP levels in 689 participants (mean CRP, 3.62 ± 5.72 mg/L). There was no difference in CRP levels with respect to calcium versus placebo treatment assignment (P = 0.99). After adjustment for potential confounders, we found no association between CRP level and risk of recurrent adenoma or advanced lesion [quartile 4 vs. quartile 1: RR, 95% confidence interval (CI) = 0.99 (0.73-1.34) and 0.92 (0.49-1.75), respectively]. Similarly, no association was seen between CRP levels and risk of serrated polyps or proximal serrated polyps [quartile 4 vs. quartile 1: RR (95% CI) = 1.32 (0.85-2.03) and 1.19 (0.54-2.58), respectively]. In conclusion, this large prospective colorectal adenoma chemoprevention study found no significant relationship between CRP levels and occurrence of adenomas, advanced neoplasms, or serrated polyps.
Inter-Rater Agreement of the Classification of Intraoperative Adverse Events (ClassIntra) in Abdominal Surgery (2021)

ClassIntra has an almost perfect inter-rater agreement for the classification of iAEs. An increasing grade of ClassIntra was associated with a higher incidence of postoperative complications. Discrepancies in grading related to common complications in abdominal procedures mostly consisted of intraoperative bleeding and adhesion-related injuries. Grading of interoperative events in abdominal surgery might further improve by consensus regarding the definitions of a number of frequent events.
Towards millimeter-wave high PAE high power using ultrathin Al-rich barrier GaN devices (2014)

We report on the development of an emerging AlN/GaN/AlGaN double heterostructure for millimeter-wave applications. These types of novel heterostructures are indeed extremely promising for high frequency applications, however, limited today in terms of drain bias operation typically around 20 V and power-added-efficiency (PAE). In this work, high RF output power density at drain bias above 30 V is demonstrated for the first time on a 6 nm ultrathin barrier AlN/GaN double heterostructure. Furthermore, state-of-the-art PAE has been achieved up to 40 GHz owing to the control of device leakage current, material and processing quality and current collapse under high electric field in spite of the very close proximity of the surface charges and the 2DEG.
Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences (2020)

ABSTRACT Congenital blindness is associated with atypical morphology, and functional connectivity within and from, visual cortical regions; changes that are hypothesized to originate from a life-long absence of visual input and could be regarded as a general (re)organization principle of sensory cortices. Challenging this is the fact that individuals with congenital anosmia (life-long olfactory sensory loss) display little to no morphological changes in primary olfactory cortex. To determine whether olfactory input from birth is essential to establish and maintain normal functional connectivity in olfactory processing regions, akin to the visual system, we assessed differences in functional connectivity within olfactory cortex between individuals with congenital anosmia (n=33) and matched controls (n=34). Specifically, we assessed differences in connectivity between core olfactory processing regions as well as differences in regional homogeneity and homotopic connectivity within primary olfactory cortex. In contrast to congenital blindness, none of the analyses indicated atypical connectivity in individuals with congenital anosmia. In fact, post-hoc Bayesian analysis provided support for an absence of group differences. These results suggest that a lifelong absence of olfactory experience has limited impact on the functional connectivity in olfactory cortex, a finding that indicates a clear difference between sensory modalities in how sensory cortical regions develop.
ChemInform Abstract: Cyclization of Allenyne‐1,6‐diols Catalyzed by Gold and Silver Salts: An Efficient Selective Synthesis of Dihydrofuran and Furan Derivatives. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
THERMODYNAMICS OF AMINO-ACID DISSOCIATION IN MIXED-SOLVENTS .3. GLYCINE IN AQUEOUS GLUCOSE SOLUTIONS FROM 5-DEGREES-C TO 45-DEGREES-C (1992)

The first thermodynamic dissociation constants of glycine in 5, 15 mass % glucose + water mixed solvents at five temperatures from 5 to 45-degrees-C have been determined from precise emf measurements of a cell without liquid junction using hydrogen and Ag-AgCl electrodes and a new method of polynomial approximation proposed on the basis of Pitzer's electrolytic solution theory in our previous paper. The results obtained from both methods agree within experimental error. The standard free energy of transfer for HCl from water to aqueous mixed solvent have been calculated and the results are discussed.
Infrared Screening of Residential Buildings for Energy Audit Purposes: Results of a Field Test (2013)

In the European Union (EU), the building sector is responsible for approximately 40% of total energy consumption. The existing building stock is inefficient and can, and indeed must be retrofitted to address this issue. The practical implementation of the European strategies requires knowledge of the energy performance of existing buildings through energy audit techniques. Application of thermography in the fields of energy are very widespread, since, through such a non-invasive investigation, and through correct interpretation of infrared images, it is possible to highlight inefficiencies in buildings and related facilities. The paper shows and discusses the results of an infrared audit campaign on 14 existing buildings located in Milan Province (Italy) made in different construction periods and characterised, therefore, by different building technologies. The U-values obtained in an indirect way through the thermography of the opaque walls of the buildings investigated, were compared with the actual known values in order to verify the reliability of the method and the possible margin of error. The study indicated that the category of buildings in which the application of this method is sufficiently reliable is that of solid-mass structure buildings, the most widespread in Italy, whereas in the case of buildings whose external walls are insulated, the percentage of deviation is very high.
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling (2016)

Photoaffinity labelling is a useful method for studying how proteins interact with ligands and biomolecules, and can help identify and characterise new targets for the development of new therapeutics. We present the design and synthesis of a novel multifunctional benzophenone linker that serves as both a photo-crosslinking motif and a peptide stapling reagent. Using double-click stapling, we attached the benzophenone to the peptide via the staple linker, rather than by modifying the peptide sequence with a photo-crosslinking amino acid. When applied to a p53-derived peptide, the resulting photoreactive stapled peptide was able to preferentially crosslink with MDM2 in the presence of competing protein. This multifunctional linker also features an extra alkyne handle for downstream applications such as pull-down assays, and can be used to investigate the target selectivity of stapled peptides.
APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New Directions (2021)

In the realm of DNA repair, base excision repair (BER) protein, APE1/Ref-1 (Apurinic/Apyrimidinic Endonuclease 1/Redox Effector - 1, also called APE1) has been studied for decades. However, over the past decade, APE1 has been established as a key player in reduction-oxidation (redox) signaling. In the review by Caston <i>et al.</i> (<i>The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease),</i> multiple roles of APE1 in cancer and other diseases are summarized. In this Review, we aim to expand on the contributions of APE1 to various diseases and its effect on disease progression. In the scope of cancer, more recent roles for APE1 have been identified in cancer cell metabolism, as well as chemotherapy-induced peripheral neuropathy (CIPN) and inflammation. Outside of cancer, APE1 signaling may be a critical factor in inflammatory bowel disease (IBD) and is also an emergent area of investigation in retinal ocular diseases. The ability of APE1 to regulate multiple transcription factors (TFs) and therefore multiple pathways that have implications outside of cancer, makes it a particularly unique and enticing target. We discuss APE1 redox inhibitors as a means of studying and potentially combating these diseases. Lastly, we examine the role of APE1 in RNA metabolism. Overall, this article builds on our previous review to elaborate on the roles and conceivable regulation of important pathways by APE1 in multiple diseases.
Laboratory Models for the Study of Normal and Pathologic Wound Healing (2017)

Current knowledge of wound healing is based on studies using various in vitro and in vivo wound models. In vitro models allow for biological examination of specific cell types involved in wound healing. In vivo models generally provide the full spectrum of biological responses required for wound healing, including inflammation and angiogenesis, and provide cell-cell interactions not seen in vitro. In this review, the authors aim to delineate the most relevant wound healing models currently available and to discuss their strengths and limitations in their approximation of the human wound healing processes to aid scientists in choosing the most appropriate wound healing models for designing, testing, and validating their experiments.
High-frequency mobilization of broad-host-range plasmids into Neisseria gonorrhoeae requires methylation in the donor (1991)

Antibiotic resistance in Neisseria gonorrhoeae has been associated with the acquisition of R plasmids from heterologous organisms. The broad-host-range plasmids of incompatibility groups P (IncP) and Q (IncQ) have played a role in this genetic exchange in nature. We have utilized derivatives of RSF1010 (IncQ) and RP1 (IncP) to demonstrate that the plethora of restriction barriers associated with the gonococci markedly reduces mobilization of plasmids from Escherichia coli into strains F62 and PGH 3-2. Partially purified restriction endonucleases from these gonococcal strains can digest RSF1010 in vitro. Protection of RSF1010-km from digestion by gonococcal enzymes purified from strain F62 is observed when the plasmid is isolated from E. coli containing a coresident plasmid, pCAL7. Plasmid pCAL7 produces a 5'-MECG-3' cytosine methylase (M.SssI). The M.SssI methylase only partially protects RSF1010-km from digestion by restriction enzymes from strain PGH 3-2. Total protection of RSF1010-km from PGH 3-2 restriction requires both pCAL7 and a second coresident plasmid, pFnuDI, which produces a 5'-GGMECC-3' cytosine methylase. When both F62 and PGH 3-2 are utilized as recipients in heterospecific matings with E. coli, mobilization of RSF1010 from strains containing the appropriate methylases into the gonococci occurs at frequencies 4 orders of magnitude higher than from strains without the methylases. Thus, protection of RSF1010 from gonococcal restriction enzymes in vitro correlates with an increase in the conjugal frequency. These data indicate that restriction is a major barrier against efficient conjugal transfer between N. gonorrhoeae and heterologous hosts.
Interruption of T‐cell signal transduction by lentivirus lytic peptides from HIV‐1 transmembrane protein (1998)

Two peptide segments designated LLP1 (residues 828-855) and LLP2 (residues 768-788) of the HIV-1 transmembrane (TM) envelope protein display structural and functional properties of calmodulin (CaM) binding. These LLP segments may contribute to cytopathogenesis by binding cellular CaM and inhibiting normal CaM-regulated signal transduction pathways. To determine whether these peptides could interrupt signal transduction in vivo, a cellular assay which uses a reporter gene linked to the nuclear factor of activated T cells (NF-AT) was used. Signal transduction perturbation was tested by exogenous addition of LLPs, W-7 or ionomycin; the LLPs inhibited NF-AT-mediated signal transduction as measured by reduced reporter activity. The LLP inhibition profile of NF-AT-driven luciferase activity was similar to the CaM inhibitor W-7. This was in direct contrast to ionomycin, a mobile calcium ion carrier which caused a significant increase in luciferase activity. These findings are consistent with the hypothesis that the CaM-binding properties of TM may contribute to defects in signal transduction leading to the T-cell anergy observed in patients infected with HIV-1.
Development of a spoken language system (1992)

The primary objective of this project is to develop a robust, high-performance spoken language system. We have achieved this by integrating the BYBLOS speech recognition system with the DELPHI natural language processing system to produce the HARC (Hear And Respond to Continuous speech) system.
Synthesis and Gas Transport Properties of Hydroxyl-Functionalized Polyimides with Intrinsic Microporosity (2012)

A newly designed diamine monomer, 3,3,3′,3′-tetramethyl-1,1′-spirobisindane-5,5′-diamino-6,6′-diol, was successfully used to synthesize two types of polyimides for membrane-based gas separation applications. The novel polymers integrate significant microporosity and polar hydroxyl groups, showing the combined features of polymers of intrinsic microporosity (PIMs) and functional polyimides (PIs). They possess high thermal stability, good solubility, and easy processability for membrane fabrication; the resulting membranes exhibit good permeability owing to the intrinsic microporosity introduced by the highly contorted PIM segments as well as high CO2/CH4 selectivity that arises from the hydroxyl groups. The membranes show CO2/CH4 selectivities of >20 when tested with a 1:1 CO2/CH4 mixture for feed pressures up to 50 bar. In addition, the incorporation of hydroxyl groups and microporosity in the polymers enhances their affinity to water, leading to remarkable water sorption capacities of up to 22 wt % at 35 °C and 95% relative humidity.
A Proxy Communication Method in Machine‐to‐Machine System to Enable the Device Connection to Different Multiple Services and Its Implementation (2013)

SUMMARY The use of machine‐to‐machine ( M2M ) systems has spread among people seeking to connect devices with remote systems via the Internet to provide services such as remote maintenance and remote energy management without human intervention. For the access network for M2M systems, not only security and immediacy, but also multiservice connectivity is required, which makes it possible to connect devices with multiple services. In this paper, an M2M proxy communication method is proposed as a communication method that achieves multiservice connectivity and security and immediacy at the same time. In the proposed method, a proxy server located between devices and application servers relays communications among them. In the relay processing, multiservice connectivity of the access network is achieved by performing access or exclusive control to devices. By adopting the M2M proxy communication method, the access network simultaneously provides multiservice connectivity, security, and immediacy at low cost without introducing any special scheme into devices. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(12): 74–84, 2013; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/ecj.11474
Carbon‐Based Metal‐Free ORR Electrocatalysts for Fuel Cells: Past, Present, and Future (2019)

Replacing precious platinum with earth-abundant materials for the oxygen reduction reaction (ORR) in fuel cells has been the objective worldwide for several decades. In the last 10 years, the fastest-growing branch in this area has been carbon-based metal-free ORR electrocatalysts. Great progress has been made in promoting the performance and understanding the underlying fundamentals. Here, a comprehensive review of this field is presented by emphasizing the emerging issues including the predictive design and controllable construction of porous structures and doping configurations, mechanistic understanding from the model catalysts, integrated experimental and theoretical studies, and performance evaluation in full cells. Centering on these topics, the most up-to-date results are presented, along with remarks and perspectives for the future development of carbon-based metal-free ORR electrocatalysts.
Prädisposition für eine vermehrte Echogenität der Substantia nigra (2005)

Fragestellung: Patienten mit idiopathischem Parkinson-Syndrom (IPS) zeigen eine vergrößerte Echogenitätsfläche der Substantia nigra (SN) in der Transkraniellen Sonographie (TCS). Diese Studie untersucht die Häufigkeit einer erhöhten Echogenität bei 1. und 2. gradigen Verwandten, sowie die mögliche Assoziation des Ultraschallmerkmales und einer verminderten Riechfunktion.
Photochemistry of halogenocarbon compounds. Part 5. Photolysis of fluorinated 1,2,3-triazine derivatives (1990)

Photolysis experiments are described on perfluoro-1,2,3-triazine (9) and its corresponding perfluoro-isopropyl derivatives. A polymer was obtained from (9) but a dimer of perfluoro-2,4-di-isopropylazete (16) is obtained, from (15) quantitatively. The endo structure of the dimer is revealed by formation of a stable carbanion on addition of CsF. Trapping of the azete (16) with furan gave interconvertible 1 :1 cycloaddition products. Products consistent with co-dimerisation of azetes are described.