gebhart/patrepeval huggingface dataset:
HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer. (1993)

Tumor-associated lymphocytes (TAL) from the malignant ascites and tumor-infiltrating lymphocytes (TIL) from the solid tumor were isolated from six consecutive untreated ovarian cancer patients. Tumor-specific CTL were generated from both TAL and TIL using solid phase anti-CD3, low dose IL-2 (50 IU/ml), and repeated tumor stimulation. The specificity of TAL and TIL was tested in standard cytotoxicity assays using autologous tumor, several allogeneic ovarian tumors, and the NK-sensitive cell line, K562. Anti-HLA-A-B-C mAb, W6/32, was used to demonstrate that these tumor-specific TAL and TIL were HLA class I-restricted. The ability of the ascitic and solid tumor to present Ag by HLA class I was assessed using Brefeldin A, a fungal metabolite that blocks the endogenous Ag-processing pathway in the viral model. Brefeldin A significantly inhibited tumor-specific cytotoxicity as well as HLA class I expression on the cell surface, suggesting an endogenous source of tumor-associated Ag. Despite previous reports of antigenic heterogeneity in ovarian cancer, shared tumor-associated Ag were shown to exist in this disease as demonstrated by significant allogeneic recognition of HLA-A2-matched patients as opposed to unmatched controls. Specifically, CTL from HLA-A2+ patients lysed HLA-A2+ allogeneic targets significantly better than HLA-A2- allogeneic or HLA-A2+ melanoma targets. There was no such difference with HLA-A2- effectors. Furthermore, HLA-A2 was confirmed to be a major restriction element in ovarian cancer by the blocking of HLA-A2+ effectors against both autologous and allogeneic HLA-A2+ targets with the anti-HLA-A2 mAb, BB7.2. These findings verify a similar lymphocyte/tumor interaction as has been documented in melanoma, suggesting a common mechanism of recognition of these human tumors by lymphocytes.
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110 (2015)

Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. We previously discovered that CDK2 inhibition causes lung cancer cells with more than two centrosomes to undergo multipolar cell division leading to apoptosis, defined as anaphase catastrophe. Cells with activating KRAS mutations were especially sensitive to CDK2 inhibition. Mechanisms of CDK2-mediated anaphase catastrophe and how activated KRAS enhances this effect were investigated. Live-cell imaging provided direct evidence that following CDK2 inhibition, lung cancer cells develop multipolar anaphase and undergo multipolar cell division with the resulting progeny apoptotic. The siRNA-mediated repression of the CDK2 target and centrosome protein CP110 induced anaphase catastrophe of lung cancer cells. In contrast, CP110 overexpression antagonized CDK2 inhibitor-mediated anaphase catastrophe. Furthermore, activated KRAS mutations sensitized lung cancer cells to CDK2 inhibition by deregulating CP110 expression. Thus, CP110 is a critical mediator of CDK2 inhibition-driven anaphase catastrophe. Independent examination of murine and human paired normal-malignant lung tissues revealed marked upregulation of CP110 in malignant versus normal lung. Human lung cancers with KRAS mutations had significantly lower CP110 expression as compared with KRAS wild-type cancers. Thus, a direct link was found between CP110 and CDK2 inhibitor antineoplastic response. CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations.
Intratumoral cisplatin/epinephrine gel in advanced head and neck cancer: A multicenter, randomized, double‐blind, phase III study in North America (2003)

This phase III trial showed that CDDP/epi gel significantly reduces tumor burden, palliates tumor-related symptoms, and is an effective local treatment for recurrent tumors.
Photoactive Blend Morphology Engineering through Systematically Tuning Aggregation in All‐Polymer Solar Cells (2018)

Abstract Polymer aggregation plays a critical role in the miscibility of materials and the performance of all‐polymer solar cells (APSCs). However, many aspects of how polymer texturing and aggregation affect photoactive blend film microstructure and photovoltaic performance are poorly understood. Here the effects of aggregation in donor–acceptor blends are studied, in which the number‐average molecular weights ( M n s) of both an amorphous donor polymer, poly[4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo[1,2‐ b ;4,5‐ b′ ]dithiophene‐2,6‐diyl‐alt‐(4‐(2‐ethylhexyl)‐3‐fluorothieno[3,4‐ b ]thiophene‐)‐2‐carboxylate‐2‐6‐diyl)] ( PBDTT‐FTTE ) and a semicrystalline acceptor polymer, poly{[ N , N′ ‐bis(2‐octyldodecyl)naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diyl]‐alt‐5,5′‐(2,2′‐bithiophene)} ( P(NDI2OD‐T2) ) are systematically varied. The photovoltaic performance is correlated with active layer microstructural and optoelectronic data acquired by in‐depth transmission electron microscopy, grazing incidence wide‐angle X‐ray scattering, thermal analysis, and optical spectroscopic measurements. Coarse‐grained modeling provides insight into the effects of polymer aggregation on the blend morphology. Notably, the computed average distance between the donor and the acceptor polymers correlates well with solar cell photovoltaic metrics such as short‐circuit current density ( J sc ) and represents a useful index for understanding/predicting active layer blend material intermixing trends. Importantly, these results demonstrate that for polymers with different texturing tendencies (amorphous/semicrystalline), the key for optimal APSC performance, photovoltaic blend morphology can be controlled via both donor and acceptor polymer aggregation.
Heterogeneity and chronology of 6q15 deletion and ERG-fusion in prostate cancer (2015)

Prostate cancer is notorious for its heterogeneity, which poses a problem for the applicability of diagnostic molecular markers. However, heterogeneity analysis can provide valuable information on the chronology in which molecular alterations arise. Here, we constructed a heterogeneity tissue microarray (TMA) comprising samples from 10 different tumor areas of 189 prostate cancers each in order to study the sequence of two frequent molecular alterations, i.e. 6q15 deletion and TMPRSS2:ERG fusion. Previous work shows a marked inverse relationship between these alterations, suggesting that presence of one of these alterations might impact development of the other. 6q15 deletion was analyzed by fluorescence in situ hybridization and ERG-expression by immunohistochemistry. Only 6.6% of 334 ERG-positive but 28.4% of 440 ERG-negative TMA spots showed 6q15 deletions (p < 0.0001). A breakdown of these data to the level of tumor foci revealed 6q deletions in 138 tumor foci that were large enough to have at least 3 analyzable TMA spots. These included 42 tumor foci with homogeneous ERG positivity and 16 with homogeneous 6q15 deletions. Remarkably, six of the 42 homogeneously ERG-positive tumor foci (14.3%) harbored small 6q15-deleted areas, but none of the 34 6q15-deleted foci showed areas of ERG positivity (p = 0.022). In conclusion, our data suggest that ERG-fusion can precede 6q15 deletion, but not vice versa. The complete absence of ERG-positive tumor areas in 6q15-deleted tumor foci further suggest that the functional consequences of 6q15 deletions may prevent the development of TMPRSS2:ERG fusions.
Pyridyl terpenoid ethers with high juvenile hormone activity (1976)

Abstract Pyridyl terpenoid ethers have outstanding juvenile hormone activity in Tenebrio molitor compared with their phenyl analogues (6,7‐epoxy‐3,7‐dimethyloct‐2‐enyl 6‐ethyl‐3‐pyridyl ether and 7‐ethoxy‐3,7‐dimethyloct‐2‐enyl 6‐ethyl‐3‐pyridyl ether are active at 100 pg/larva). The compounds were also active in Galteria mellonella and Culex pipiens .
Reversing interleukin‐2 inhibition mediated by anti–double‐stranded DNA autoantibody ameliorates glomerulonephritis in MRL‐lpr/lpr mice (2010)

These findings suggest that penetration of T cells by anti-dsDNA may inhibit IL-2 production by activating GSK-3. Moreover, blocking GSK-3 activation as well as inhibiting anti-dsDNA penetration is a potential therapeutic approach for lupus.
Obese children and myocardial deformation changes: some discrepancies but a large number of common points: reply (2014)

We thank Saltijeral et al .1 for their comments regarding our recent work entitled ‘Alterations of left ventricular myocardial strain in obese children’. We agree our findings are consistent with the results of their previous study.2 A three-dimensional myocardial strain is an undeniable step …
Blazenet: A Phototonic Implementable Wide-Area Network (1987)

Abstract : High-performance wide-area networks are required to interconnect clusters of computers connected by local and metropolitan area networks. Optical fiber technology provides long distance channel in the multi-gigabit per second range. The challenge is to provide switching nodes that handle these data rates with minimum delay, and at a reasonable cost. In this paper, we describe a packet switching network, christened 'Blazenet,' that provides low delay and has minimal memory requirements. It can be extended to support multicast and priority delivery. Such a network can revolutionize the opportunities for distributed command and control, information and resources sharing, real-time conferencing, to mention but a few applications.
Corrosion Behavior of Nickel-Free High Nitrogen Austenitic Stainless Steel in Simulated Biological Environments (2002)

The corrosion resistance of the nickel-free high nitrogen austenitic stainless steel without manganese, Fe–23Cr–2Mo–1.5N (mass%) (HNS) as biomaterials, was evaluated by the polarization test in various electrolytes: 0.9%NaCl solution (saline), phosphate buffered saline (PBS(-)), Hanks’ solution (Hanks) and Eagle’s minimum essential medium (E-MEM). Conventional austenitic stainless steel, 316L, was also polarized for comparison. The both alloys were spontaneously passivated in all electrolytes. The HNS didn’t show pitting corrosion in the polarization range in all electrolytes although the 316L showed pitting corrosion. Passive current densities of the HNS in all electrolytes were lower than those of 316L . Therefore, the HNS shows higher passivity and resistance to pitting corrosion than 316L . The passive current density in Hanks of HNS was lower than that in saline, indicating that the protectiveness of surface oxide film increased with the existence of inorganic ions such as phosphate and calcium ions. On the other hand, the passive current density in E-MEM was higher than that in Hanks, but was lower than that in saline. Consequently, the HNS must show high corrosion resistance in vivo and be a promising biomaterials.
Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots (2021)

Bone marrow adipose tissue (BMAT) has recently been recognized as a distinct fat depot with endocrine functions. However, if and how it is regulated by chronic inflammation remains unknown. Here, we investigate the amount of white fat and BMAT in HLA-B27 transgenic rats and curdlan-challenged SKG mice, two well-established models of chronic inflammatory spondyloarthritis (SpA). Subcutaneous and gonadal white adipose tissue and BMAT was reduced by 65-70% and by up to 90% in both experimental models. Consistently, B27 rats had a 2-3-fold decrease in the serum concentrations of the adipocyte-derived cytokines adiponectin and leptin as well as a 2-fold lower concentration of triglycerides. The bone marrow of B27 rats was further characterized by higher numbers of neutrophils, lower numbers of erythroblast precursors, and higher numbers of IL-17 producing CD4<sup>+</sup> T cells. IL-17 concentration was also increased in the serum of B27 rats. Using a cell culture model, we show that high levels of IL-17 in the serum of B27 rats negatively impacted adipogenesis (-76%), an effect that was reversed in the presence of neutralizing anti-IL-17 antibody. In summary, these findings show BMAT is severely reduced in two experimental models of chronic inflammatory SpA and suggest that IL-17 is involved in this process.
Prevalence of diabetes mellitus and diabetic retinopathy in Filipino vs Caucasian Americans: a retrospective cross-sectional epidemiologic study of two convenience samples. (2012)

Filipino Americans may have a higher prevalence of type 2 diabetes mellitus and diabetic retinopathy than Caucasian Americans. Among those with type 2 diabetes, however, Filipino Americans were not found to be more likely to show manifestations of diabetic retinopathy than Caucasian Americans.
MODELING AND SIMULATION OF WATER AND PVP/WATER EVAPORATING SPRAY FLOWS USING THE DIRECT QUADRATURE METHOD OF MOMENTS (2014)

The direct quadrature method of moments (DQMOM) in an axisymmetric, two-dimensional configuration is extended to model evaporating water as well as polyvinylpyrrolidone (PVP)/water solution spray flows, where the sprays are injected into a vertical spray chamber and carried by air. For model evaluation, the water/air spray is also simulated using the discrete droplet model (DDM). The droplet evaporation is described by Abramzon and Sirignano's model for the water spray, whereas for the PVP/water spray flow, the extended two-film convective bi-component model of Brenn is used with modifications to account for a bi-component spray with polymer presence and resistance due to solid layer formation. The variable liquid and film properties, convective droplet heating and evaporation, as well as droplet motion are included in the model. In the Euler−Lagrangian formulation (DDM), the spray is described by source terms in the gas phase equations. The DQMOM constitutes an Euler−Euler formulation, where the spray is modeled accounting for droplet size and velocity distribution. Droplet coalescence is considered in DQMOM and neglected in DDM. Appropriate initial and boundary conditions for the simulations are generated from experimental data. The droplet size and velocity distributions were measured with phase-Doppler anemometry (PDA). The DQMOM and DDM simulation results are compared with experimental data at various cross sections, and very good agreement is observed. In conclusion, DQMOM shows a much better performance with respect to computational costs and the ease to include droplet coalescence, and therefore, it is chosen to model the PVP/water spray flow in air, which results in similar good agreement with experimental data.
Effective Doses in Radiology and Diagnostic Nuclear Medicine: A Catalog (2008)

Medical uses of radiation have grown very rapidly over the past decade, and, as of 2007, medical uses represent the largest source of exposure to the U.S. population. Most physicians have difficulty assessing the magnitude of exposure or potential risk. Effective dose provides an approximate indicator of potential detriment from ionizing radiation and should be used as one parameter in evaluating the appropriateness of examinations involving ionizing radiation. The purpose of this review is to provide a compilation of effective doses for radiologic and nuclear medicine procedures. Standard radiographic examinations have average effective doses that vary by over a factor of 1000 (0.01-10 mSv). Computed tomographic examinations tend to be in a more narrow range but have relatively high average effective doses (approximately 2-20 mSv), and average effective doses for interventional procedures usually range from 5-70 mSv. Average effective dose for most nuclear medicine procedures varies between 0.3 and 20 mSv. These doses can be compared with the average annual effective dose from background radiation of about 3 mSv.
Practical tests for evaluating hazardous radioactive chemical wastes (1984)

This quasi-experimental field study assessed whether an incentive/reward intervention can change the drinking behavior and the subsequent levels of intoxication among college students attending fraternity parties. A total of 356 blood alcohol concentration (BAC) assessments, using hand-held breathalyzers. were obtained at two baseline and at two intervention parties at the same fratenity house. At the intervention parties, the students were informed they could win a cash prize if their BAC was below .05, and they were given nomograms to aid in monitoring their levels of intoxication. Mean BAC and the percentage of partiers with intoxication levels above .05 were significantly lower at the two intervention parties. More than twice as many partygoers were legally intoxicated (i.e., BAC > .08) at the two baseline parties than at the two intervention parties. indicating a clinically significant impact of the incentive/reward intervention. Greek-life students, in particular, were significantly less intoxicated at intervention parties, compared to baseline parties (p < .001).
Supplementary tables 1-3 from Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC) (2023)

&lt;p&gt;Supplementary table 1. Hazard ratios (95% CI) for the incidence of total cancer and cancer types by quartile of serum β-2-microglobulin (B2M), ARIC, 1990-2006. Supplementary table 2a. Hazard ratios (95% CI) a for colorectal cancer incidence in strata of select characteristics. ARIC, 1990-2006. Supplementary table 2b. Hazard ratiosa (95% CI) for lung cancer incidence in strata of selected participants' characteristics; ARIC, 1990-2006. Supplementary table 3. Hazard ratios (95% CIs)a for colorectal cancer by quartiles of combined scores based on B2M and CRP; ARIC, 1990-2006.&lt;/p&gt;
Analytical Ancestry: “Firsts” in Fluorescent Labeling of Nucleosides, Nucleotides, and Nucleic Acids (2009)

Fluorescently labeled nucleosides, nucleotides, and nucleic acids are important types of reagents for biological assay methods and underpin current methods of chromosome analysis, gel staining, DNA sequencing and quantitative PCR. Although these methods use predominantly organic fluorophores, new types of particulate fluorophores in the form of nanoparticles, nanorods, and nanotubes may provide the basis of a new generation of fluorescent labels and nucleic acid detection methods.
A Supervised Learning Concept for Reducing User Interaction in Passenger Cars (2017)

In this article an automation system for human-machine-interfaces (HMI) for setpoint adjustment using supervised learning is presented. We use HMIs of multi-modal thermal conditioning systems in passenger cars as example for a complex setpoint selection system. The goal is the reduction of interaction complexity up to full automation. The approach is not limited to climate control applications but can be extended to other setpoint-based HMIs.
Impact of Al Pre-Deposition Layer on Crystalline Quality of GaN Grown on Si(111) Substrates (2018)

The effects of Al metal pre-deposition under different conditions on GaN grown on Si(111) substrates by metal-organic chemical vapor deposition (MOCVD) have been investigated. Al pre-deposition improves surface morphology and crystal quality of GaN grown on Si. The surface morphology of Al pre-deposition layer, AlN, and GaN vary depending on Al pre-deposition temperature. With the increase of Al pre-deposition temperature, Al cluster size is observed to increase in the Al predeposition layer due to increased lateral mobility of Al atoms. The Al pre-deposition carried out at about 750 °C enables to grow pit-free GaN layer on Si(111) substrate.
ChemInform Abstract: Phenethylamines via Heck Arylation of a New Vinylamine Equivalent. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Homogeneous 2D MoTe2 p–n Junctions and CMOS Inverters formed by Atomic‐Layer‐Deposition‐Induced Doping (2017)

Recently, α-MoTe<sub>2</sub> , a 2D transition-metal dichalcogenide (TMD), has shown outstanding properties, aiming at future electronic devices. Such TMD structures without surface dangling bonds make the 2D α-MoTe<sub>2</sub> a more favorable candidate than conventional 3D Si on the scale of a few nanometers. The bandgap of thin α-MoTe<sub>2</sub> appears close to that of Si and is quite smaller than those of other typical TMD semiconductors. Even though there have been a few attempts to control the charge-carrier polarity of MoTe<sub>2</sub> , functional devices such as p-n junction or complementary metal-oxide-semiconductor (CMOS) inverters have not been reported. Here, we demonstrate a 2D CMOS inverter and p-n junction diode in a single α-MoTe<sub>2</sub> nanosheet by a straightforward selective doping technique. In a single α-MoTe<sub>2</sub> flake, an initially p-doped channel is selectively converted to an n-doped region with high electron mobility of 18 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> by atomic-layer-deposition-induced H-doping. The ultrathin CMOS inverter exhibits a high DC voltage gain of 29, an AC gain of 18 at 1 kHz, and a low static power consumption of a few nanowatts. The results show a great potential of α-MoTe<sub>2</sub> for future electronic devices based on 2D semiconducting materials.
ChemInform Abstract: Stereoselective Nucleophilic Addition Reactions of Reactive Pseudopeptides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Selective contrast-enhanced MR angiography (2000)

In this study the feasibility of intraarterial contrast administration was investigated. Its use for navigation and treatment evaluation during MR-guided intravascular interventions was explored in phantom and animal experiments. An injection protocol was developed, which accounts for sequence parameters and vessel flow rate. Tracking a bolus of contrast agent was useful to verify the catheter tip position and to assess flow conditions. Compared to intravenous contrast-enhanced magnetic resonance angiography (CE-MRA), selective contrast administration permitted a strongly reduced dose. In two-dimensional (2D) acquisitions overlap of vessels was prevented. Injection and acquisition were easily and accurately synchronized in selective 3D CE-MRA, and a high contrast concentration could be maintained during the entire acquisition. Selective injection is useful in the course of an intervention, to facilitate navigation, provide information on flow conditions, and to evaluate treatment progress repeatedly.
Azobenzene-caged sulforhodamine dyes: a novel class of ‘turn-on’ reactive probes for hypoxic tumor cell imaging (2015)

New sulforhodamine-based fluorescent 'turn-on' probes have been developed for the direct imaging of cellular hypoxia. Rapid access to this novel class of water-soluble 'azobenzene-caged' fluorophores was made possible through an easily-implementable azo-coupling reaction between a fluorescent primary arylamine derived from a sulforhodamine 101 scaffold (named SR101-NaphtNH <sub>2</sub> ) and a tertiary aniline whose N-substituents are neutral, cationic, or zwitterionic. The detection mechanism is based on the bioreductive cleavage of the azo bond that restores strong far-red fluorescence (emission maximum at 625 nm) by regenerating the original sulforhodamine SR101-NaphtNH <sub>2</sub> . This valuable fluorogenic response was obtained for the three 'smart' probes studied in this work, as shown by an in vitro assay using rat liver microsomes placed under aerobic and then under hypoxic conditions. Most importantly, the probe namely SR101-NaphtNH <sub>2</sub> -Hyp-diMe was successfully applied for imaging the hypoxic status of tumor cells (A549 cells).