gebhart/patrepeval huggingface dataset:
Analysis of antinociceptive effects of flurbiprofen enantiomers ina rat model of arthritic pain (2000)

The potential antinociceptive effects of the S(+)- and R(-)-enantiomers of flurbiprofen (SFB and RFB, respectively) were investigated when given intravenously to rats using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain. Groups of 6 rats received either vehicle or the enantiomer in turn and antinociception was determined by evaluating the dose-response curves over time. Although SFB and RFB produced dose-dependent effects with similar efficacy (SFB: 277.4 +/- 29.9 au and RFB: 293.5 +/- 20.1 au), the R(-)-enantiomer was unable to produce any antinociceptive action when assessed at the same dose ranges as SFB. It was necessary to increase the dose of RFB by 100 times to produce similar antinociception. Accordingly, S(+)-flurbiprofen was 100-fold more potent (ED50 = 0.33 +/- 0.13 mg/kg) than its antipode R(-)-(ED50 = 30.0 +/- 1.7 mg/kg). SFB generated from metabolic inversion (> 1%) after i.v. dosage of RFB, as well as impurities of SFB present in RFB preparations, tend to confirm the hypothesis that the efficacy of RFB achieved at 100 mg/kg, similar to that observed with 1 mg/kg of SFB, is attributable to SFB.
Electrochemical Analysis of Anomalous Conductivity Effects in the AgClAgI Two Phase System (1992)

Abstract The overall conductivity of the system AgCl/AgI is studied and distinct anomalies are found in the miscibility gap (Ag + ‐conductivity enhancement up to 1.5 orders of magnitude). An impedance spectroscopic investigation accompanied by studies of phase diagram and microstructure proposes two main conclusions: i) the conducting interfacial pathways are composed of homo‐ (AgX/AgX) and hetero‐(AgX/AgX′) contacts, both exhibiting enhanced conductivities (compared to AgCl and β‐AgI bulk). ii) Both pathways are characterized by vacancy conduction in the relevant space charge layers.
Problem of the unit of reference in expressing biomedical data. (1970)

This paper reviews various bases used by investigators in the biomedical field for expressing analytical data obtained from biological tissues. The advantages of certain units of reference in certain research situations and the pitfalls of other modes of expression are discussed. I suggest that authors express their data using several bases when no particular one is fully adequate. Use of wet weight, DNA, and total protein (as polypeptide) as bases would add new dimensions to the data and may suggest new possibilities for further experimental investigation.
Observations of Nonlinear Phenomena in Rotordynamics (2008)

Observations, analysis and understanding of nonlinear rotordynamic phenomena observed in aircraft gas turbine engines and other high-speed rotating machinery over the course of the author's career are described. Included are observations of sum-and-difference frequency response; effects of roller bearing clearance; relaxation oscillations; subharmonic response; chaotic response; and other generic nonlinear responses such as superharmonic and ultra-subharmonic response.
Data for: Root cause analysis for inverters in photo-voltaic solar plants (2020)

Random Committee (RC) with Random_test4 and Logistic Model Trees (LMT) with LMTver1.
Biocement—A New Material (1982)

A newly developed material, which we call biocement, consisting of bisphenol-a-glycidyl methacry-later` (‘epoxide methacrylate’) as organic matrix and Bio-ceramic Battelle, Bioglass Hench and/or pentacalcium hydroxide triphosphate (‘tri-calcium phosphate’) powder as filling particles is presented. In an extension of previous experiments, various types of this biocement, containing different admixtures of paniculate matter, were employed to test their usefulness in head surgery, in particular maxillo-facial reconstruction, on dogs and a rhesus monkey. Encouraging results were obtained with regard to (a) fixing a titanium alloimplant under some degree of mechanical stress; (b) covering a defect in the skull cap, including the closure of an artificially induced meningeal fistula with liquorrhea; and (c) reconstruction of defects in the anterior wall of frontal sinuses. Spescial emphasis is placed on direct contact between biocement and bone, interdigitations between these two, reactions of meningeal tissue, and regeneration of ciliated epithelium underneath fixed reimplants over the frontal sinus.
Liquid crystal elastomers: Influence of the orientational distribution of the crosslinks on the phase behaviour and reorientation processes (1994)

Abstract The influence of the crosslinking conditions on the phase behaviour and reorientation processes of nematic elastomers is investigated. Two series of elastomers with various network anisotropies crosslinked either in the nematic or in the isotropic state were investigated by means of IR‐dichroism and stress‐strain measurements. The experimental results clearly demonstrate that for nematic elastomers not only the coupling between the network anisotropy and the state of order has to be considered. It is shown that the influence of the crosslinks and their orientational distribution on the phase behaviour, the state of order as well as on director reorientation processes cannot be neglected.
Porous Starch Materials via Supercritical- and Freeze-Drying (2019)

The production of porous materials based on starch has been explored with supercritical drying-yielding aerogel-and freeze-drying. The two drying procedures were applied on the same gelling solution of amylomaize starch pasted at 140 °C and for two concentrations (5 and 10 wt.%). After gelation and retrogradation, water from the samples to be supercritically dried was exchanged to ethanol. The resulting starch aerogel presented high specific surface area (197 m²/g). Freeze-drying was assessed by investigating the effect of the gelation, retrogradation, freezing temperature, and sublimation pressure. The resulting starch materials were macroporous, with limited specific surface area and limited mechanical integrity. Cohesive open cell foam with pore size of ~20 µm was produced by quenching the hot starch melt in liquid nitrogen. The highest specific surface area obtained with freeze-drying was 7.7 m²/g for the hot starch melt frozen at -20 °C.
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments (2019)

Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control microbiota composition and play a key role in intestinal barrier function and homeostasis. Dynamic conditions in the local microenvironment, such as pH and redox potential, significantly affect the antimicrobial spectrum. In contrast to oxidized peptides, some reduced defensins exhibit increased vulnerability to proteolytic degradation. In this report, we investigated the susceptibility of Paneth-cell-specific human α-defensin 5 (HD-5) and -6 (HD-6) to intestinal proteases using natural human duodenal fluid. We systematically assessed proteolytic degradation using liquid chromatography-mass spectrometry and identified several active defensin fragments capable of impacting bacterial growth of both commensal and pathogenic origins. Of note, incubation of mucus with HD-5 resulted in 255-8,000 new antimicrobial combinations. In contrast, HD-6 remained stable with consistent preserved nanonet formation. In vivo studies demonstrated proof of concept that a HD-5 fragment shifted microbiota composition (e.g., increases of <i>Akkermansia</i> sp.) without decreasing diversity. Our data support the concept that secretion of host peptides results in an environmentally dependent increase of antimicrobial defense by clustering in active peptide fragments. This complex clustering mechanism dramatically increases the host's ability to control pathogens and commensals. These findings broaden our understanding of host modulation of the microbiome as well as the complexity of human mucosal defense mechanisms, thus providing promising avenues to explore for drug development.
A predictive sampling scale model for direct torque control of the induction machine fed by multilevelvoltage-source inverters (1999)

This paper is aimed at the characterization of Electric Power Drive Systems based on the Induction Machine fed by Multi-level Voltage-source inverters, to be used within instantaneous torque and flux control methodologies. The input/output transfer function for a N-level inverter is discussed and the correspondent available output voltage vectors, as well as the input sequences that give them rise, represented in the stationary Park reference plane. Concerning the induction machine characterization, an analytical study on the torque and stator flux instantaneous behavior is made, demonstrating that the first one highly depends on the delivered torque and speed. In consequence, a sampling scale predictive model of the induction machine is deduced in order to make possible the optimal choice of the inverter configuration for a sampling period. Finally, a DEADBEAT based control law is discussed and simulated as an illustration example of both the voltage-inverter and induction machine models presented within this paper.
Influence of LiPF6on the Aluminum Current Collector Dissolution in High Voltage Lithium Ion Batteries after Long-Term Charge/Discharge Experiments (2017)

The long-term influence of the most commonly used conducting salt in electrolyte formulations, lithium hexafluorophosphate, on the aluminum current collector stability in high voltage lithium ion batteries was investigated. By means of different surface sensitive techniques (scanning electron microscopy, atomic force microscopy and X-ray photoelectron spectroscopy), after 1003 simulated charge/discharge cycles, anodic aluminum dissolution was found to take place at elevated potential (4.95 V vs. Li/Li+) but only to a minor extent. Pitting of the Al collector could be assessed in the nanometer range. Furthermore, it could be revealed that local pit formation is related to local "native" grooves on the aluminum foil, which develop during the production process of the aluminum foil. The obtained results were evaluated and compared to a reference electrolyte containing the alternative conducting salt lithium bis(trifluoromethanesulfonyl)imide. Our findings imply two possible mechanisms for the occurring Al dissolution behavior at elevated potentials. Either, an accelerated aluminum dissolution process, or a continuous passivation/LiPF6-decomposition process.
Are production, reading, and listening co-lateralized ? fMRI investigation in 296 healthy individuals (2017)

International audience
An iterative approach to comprehensive performance evaluation of integrated services networks (2002)

Future networks are expected to integrate diverse services. For this purpose, new algorithms and protocols have been proposed for link scheduling, admission control, and routing. The interaction between these three components is crucial to the performance of the network. However, this interaction is difficult to model realistically using available techniques. We present an iterative discrete-time approach that yields a realistic model which takes into account this interaction. The model applies to connection-oriented networks with different types of real-time connections. It allows the investigation of various control schemes for both transient and steady-state performances. Preliminary results indicate that our approach is computationally much cheaper than discrete-event simulation, and yields sufficiently accurate performance measures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structural and electrostatic effects at the surfaces of size- and charge-selected aqueous nanodrops (2017)

The effects of ion charge, polarity and size on the surface morphology of size-selected aqueous nanodrops containing a single ion and up to 550 water molecules are investigated with infrared photodissociation (IRPD) spectroscopy and theory. IRPD spectra of M(H<sub>2</sub>O) <sub><i>n</i></sub> where M = La<sup>3+</sup>, Ca<sup>2+</sup>, Na<sup>+</sup>, Li<sup>+</sup>, I<sup>-</sup>, SO<sub>4</sub><sup>2-</sup> and supporting molecular dynamics simulations indicate that strong interactions between multiply charged ions and water molecules can disrupt optimal hydrogen bonding (H-bonding) at the nanodrop surface. The IRPD spectra also reveal that "free" OH stretching frequencies of surface-bound water molecules are highly sensitive to the ion's identity and the OH bond's local H-bond environment. The measured frequency shifts are qualitatively reproduced by a computationally inexpensive point-charge model that shows the frequency shifts are consistent with a Stark shift from the ion's electric field. For multiply charged cations, pronounced Stark shifting is observed for clusters containing ∼100 or fewer water molecules. This is attributed to ion-induced solvent patterning that extends to the nanodrop surface, and serves as a spectroscopic signature for a cation's ability to influence the H-bond network of water located remotely from the ion. The Stark shifts measured for the larger nanodrops are extrapolated to infinite dilution to obtain the free OH stretching frequency of a surface-bound water molecule at the bulk air-water interface (3696.5-3701.0 cm<sup>-1</sup>), well within the relatively wide range of values obtained from SFG measurements. These cluster measurements also indicate that surface curvature effects can influence the free OH stretching frequency, and that even nanodrops without an ion have a surface potential that depends on cluster size.
382. Vitamin D Supplementation and Covid 19: Results from the U.S. N3C Data Enclave (2021)

Abstract Background It is estimated that 18% of adults in the U.S. take Vitamin D supplements. Some observational studies suggest that vitamin D supplementation activates the innate immune system and reduces the incidence and severity of viral infections. During the SARS-CoV-2 pandemic, vitamin D supplements were touted as a potential therapy to prevent the disease and/or complications. However, supportive evidence is lacking. Methods The National COVID Cohort Collaborative (N3C) enclave is the largest COVID-19 data base with nearly 1.4 million positive patients at 56 sites in the U.S. We performed a retrospective analysis of vitamin D supplementation, either prescribed before or during hospitalization for SARS-CoV-2. Results 137,399 people took vitamin D supplements out of 1.4 million. Females prescribed vitamin D outnumbered males by almost 2:1, whereas in non-users there were no sex differences. Most supplement users were older than 50. African Americans constituted 13% of the non-users, but 23% of those prescribed vitamin D. Infected individuals with any vitamin D supplementation, pre-Covid, post-Covid or both, had a 6.66% mortality rate vs 2% mortality in non-users. Similarly, nearly a third of the supplement users were hospitalized compared to 11% in the non-users. The Charlson Co-Morbidity Index was 3.0±3 (SD) in users vs 1.0±2 (SD) in non-users. Conclusion 10% of SARS-CoV-2 infected patients were taking vitamin D. They tended to be older, more likely to be African American and have significant co-morbidities. Hospitalization and mortality were higher among those taking Vitamin D in this cohort. Vitamin D is widely used to prevent and treat SARS-CoV-2 but without evidence of efficacy. Disclosures Sally L. Hodder, M.D., Gilead (Advisor or Review Panel member)Merck (Grant/Research Support, Advisor or Review Panel member)Viiv Healthcare (Grant/Research Support, Advisor or Review Panel member)
Role of Ceria in Oxidative Dehydrogenation on Supported Vanadia Catalysts (2010)

The effect of the suppport on oxidative dehydrogenation activity for vanadia/ceria systems is examined for the oxidation of methanol to formaldehyde by use of well-defined VO(x)/CeO(2)(111) model catalysts. Temperature-programmed desorption at low vanadia loadings revealed reactivity at much lower temperature (370 K) as compared to pure ceria and vanadia on inert supports such as silica. Density functional theory is applied and the energies of hydrogenation and oxygen vacancy formation also predict an enhanced reactivity of the vanadia/ceria system. At the origin of this support effect is the ability of ceria to stabilize reduced states by accommodating electrons in localized f-states.
Tubal factors in infertility (1992)

Proximal, distal, and peritubal damage can be caused by a number of pathologic processes such as inflammation, endometriosis, and surgical trauma. The diagnosis of tubal occlusion relies primarily on hysterosalpingography, hysteroscopy, and laparoscopy. A number of innovative diagnostic procedures such as sonosalpingography, falloposcopy, and selective salpingography improved our ability to accurately diagnose tubal pathology. The long-standing surgical corrective approach to treat tubal occlusion has been replaced by noninvasive methods in selected patients with endoluminal damage. The development of noninvasive transcervical catheter methods to recanalize proximally obstructed fallopian tubes also allows access to the fallopian tubes for deposition of gametes and embryos and improves the diagnosis and treatment of tubal pregnancies. Transcervical tubal cannulation reduces the risks, costs, and morbidity of surgical procedures. The diverse applications of the transcervical tubal approach may also replace surgical invasive procedures in assisted reproductive procedures. Although radical changes have occurred in the treatment of proximal tubal occlusion, the repair of distal and peritubal damage frequently yields disappointing results, and will probably remain the challenge of the 1990s.
Control of Ground State Dynamics in Polymers with Shaped Pulses (2002)

Coherent control of the ground state vibrational dynamics via a Raman process is demonstrated in polydiacetylene. The relative amplitudes and phases of the normal modes could be set.
RECEPTOR PHOSPHORYLATION (1984)

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, U.S.A.
Temperature tunable behavior of planar terahertz metamaterials fabricated on bulk strontium titanate substrates (2011)

We demonstrate thermal tuning of the inductive capacitive (LC) resonance in terahertz metamaterials made up of gold split-ring resonator (SRR) arrays on ferroelectric bulk Strontium Titanate (STO) substrates. Heating the metamaterial from temperature of 150 K to 425 K causes as high as 69% blue shift in metamaterial resonance frequency due to the change in refractive index of the substrate.
Activity of two doses of rifampin against Mycobacterium leprae. (1994)

In the course of a clinical trial designed to re-examine the bactericidal efficiency of 600-mg doses of rifampin (RMP) against Mycobacterium leprae, two doses of RMP, either 600 mg or 1200 mg, were administered 28 days apart to 29 previously untreated patients with lepromatous or borderline leprosy. Seven, 28, and 35 days after the start of the trial, skin biopsies were performed and immunologically normal mice were inoculated with 5 x 10(3) or 10(4) M. leprae in each hind foot pad. The patients assigned to the two regimens did not differ significantly in terms of sex, age, disease classification, bacterial index, or the concentration of M. leprae in the skin lesion biopsied for the inoculation of mice. The concentrations of organisms in the skin-biopsy specimens did not change significantly over the course of the trial among the patients, whether they were being treated by the first or the second regimen. The M. leprae recovered from specimens obtained from 21 of the patients, before beginning treatment, multiplied in a majority of the mice inoculated. The results of mouse inoculation confirmed the rapid bactericidal effects of RMP against M. leprae: a single dose of RMP rendered the organisms obtained from all but two of the patients incapable of multiplying in mice. No significant difference was demonstrated between the two regimens, nor was an additional effect of the second dose of RMP observed.
Pneumococcal Endocarditis (1984)

SummaryThe clinical and bacteriological observation of a 52 year old man with pneumococcal endocarditis is presented. Two successive surgical interventions combined with appropriate antibiotic treatment cured our patient. The pathogenesis of pneumococcal infection and the problems involved in bacteriological diagnosis are discussed.
Robust visual servoing in 3-D reaching tasks (1996)

This paper describes a novel approach to the problem of reaching an object in space under visual guidance. The approach is characterized by a great robustness to calibration errors, such that virtually no calibration is required. Servoing is based on binocular vision: a continuous measure of the end-effector motion field, derived from real-time computation of the binocular optical flow over the stereo images, is compared with the actual position of the target and the relative error in the end-effector trajectory is continuously corrected. The paper outlines the general framework of the approach, shows how visual measures are obtained and discusses the synthesis of the controller along with its stability analysis. Real-time experiments are presented to show the applicability of the approach in real 3-D applications.
Detection of adsorbed explosive molecules using thermal response of suspended microfabricated bridges (2008)

Here we present a thermophysical technique that is capable of differentiating vapor phase adsorbed explosives from nonexplosives and is additionally capable of differentiating individual species of common explosive vapors. This technique utilizes pairs of suspended microfabricated silicon bridges that can be heated in a controlled fashion. The differential thermal response of the bridges with and without adsorbed explosive vapor shows unique and reproducible characteristics depending on the nature of the adsorbed explosives. The tunable heating rate method described here is capable of providing unique signals for subnanogram quantities of adsorbed explosives within 50 ms.
A dynamic QoS algorithm for wireless AV home networks (2006)

Due to the high bandwidth demands and the variability of wireless link quality, AV transmission has presented challenges to wireless networks. Traditional technologies have achieved little success. IEEE 802.11e standard (IEEE P802.11e/D13.0, 2005) has introduced dedicated bandwidth in combination with prioritization techniques at MAC layer to enhance QoS capability of wireless networks. However, the QoS mechanisms provided in IEEE 802.11e standard face challenges if the required bandwidth is greater than the available bandwidth (P.C. Li, 2003). Therefore, new QoS technologies beyond MAC layer need to be deployed for a complete QoS solution. This paper presents a dynamic QoS algorithm at LLC layer for wireless AV networks.
Supplementary Table S3 from Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells <i>In vitro</i> and <i>In vivo</i> (2023)

&lt;p&gt;Embryonic stem cell and EMT-MET markers selected for the nCounter® Customized Gene Expression Codeset showing differentially expressed genes (p &lt; 0.05) between CTRLs and SFN-treated groups during primary tumor growth&lt;/p&gt;
Scanning limitations of liquid-crystal displays (1974)

The scanning limitations of rms-responding liquid-crystal devices as influenced by device characteristics, the type of matrix addressing scheme, and waveform tolerances are quantified in this paper. An rms selection scheme that yields a greater number of scanned lines than a 3:1 selection scheme is presented and analyzed, together with a two-frequency addressing scheme that overcomes limitations on scanning associated with the cutoff frequency for dynamic-scattering, Dynamic-scattering liquid-crystal displays are the main emphasis of this paper. However, many of the results apply to field-effect liquid-crystal displays.