gebhart/patrepeval huggingface dataset:
Bacillus thuringiensis var. morrisonistrain PG14: nucleotide sequence of a gene encoding a 27kDa crystal protein (1987)

Journal Article Bacillus thuringiensis var. morrisoni strain PG14: nucleotide sequence of a gene encoding a 27kDa crystal protein Get access David J. Earp, David J. Earp Cambridge University, Department of BiochemistryTennis Court Road, Cambridge CB2 1QW, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar David J. Ellar David J. Ellar Cambridge University, Department of BiochemistryTennis Court Road, Cambridge CB2 1QW, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 15, Issue 8, 24 April 1987, Page 3619, https://doi.org/10.1093/nar/15.8.3619 Published: 24 April 1987 Article history Received: 30 March 1987 Published: 24 April 1987
Antiidiotypic Antibodies as Probes for Receptor Structure and Function (1985)

The immune system has evolved to recognize itself and respond to nonself (antigens) within the context of self (1, 2). The immune response needs to be specific, augmentable and yet limited in extent and temporally to the defense requirements of the organism (1, 2). Rearrangement of immunoglobulin (Ig)1 genes brings one VH segment into proximity with those of one of several J segments and a single CL segment and VH, D, J, and one of eight CH segments to assemble active light and heavy chain genes, respectively. This process entails somatic recombination and RNA splicing. The large number of gene line components to choose from, point mutations in V region and flexibility of the recombinational process between certain segments contribute to the extraordinary antibody diversity (2, 3).
S3258 Characterization of Referral for Transient Elastography With Fibroscan® in Hawaii in Patients With Chronic Liver Disease (2020)

INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) will become the leading indication for liver transplantation in the U.S in the next decade. Amongst those with non-cirrhotic Chronic Liver Disease (CLD), NAFLD has been found to be the most common cause of CLD in Japanese Americans, and Native Hawaiians, followed by Latinos and Caucasians. Prevalence rates of NAFLD are speculated to be even higher in “westernized Asian populations” making this even more concerning for the population in the state of Hawai’i. Risk stratification of patients with NAFLD is essential in preventing progression. Transient elastography using FibroScan® is useful in stratifying patients with CLD as it is noninvasive and gives real-time results regarding hepatic fibrosis and level of fatty changes. While hepatitis B (HBV) and hepatitis C (HCV) are readily diagnosed and well established as major causes of cirrhosis, NAFLD represents an insidious disease without a clear path forward for the primary care provider (PCP) or the patient. METHODS: This was a retrospective study looking at Fibroscan® results of approximately 1101 patients in Hawai’i. Patients were de-identified, grouped by diagnosis, age, gender, Controlled attenuation parameter (CAP) score and kilopascals (kPa). Median age, kPa, and CAP scores were compared using Wilcoxon rank sum test between groups. RESULTS: In the cohort of 1101 patients, the most common indications for Fibroscan® were HCV (324), HBV (285), NAFLD (298) and other (194). Groups with the highest kPa values were those with known cirrhosis, abnormal transaminases, HCV, followed by abnormal LFTs, Nonalcoholic Fatty Liver (NAFL), and Nonalcoholic steatohepatitis (NASH). The median age of patients referred for Fibroscan® for NAFLD was 60.19 vs. HBV or HCV at 57.51 (P < 0.001). There was no significant difference between median kPa of NAFLD vs. HBV or HCV 5.8 vs. 5.5 respectively (P = 0.22). Median CAP scores of NAFLD vs. HBV or HCV groups were 322 vs. 222 respectively (P < 0.001). CONCLUSION: Patients receiving Fibroscan® in Hawai’i for NAFLD were significantly older than those with HBV or HCV. The kPa values were not statistically different in these two groups but CAP values were significantly higher patients with NAFLD. These findings indicate a bias towards earlier referral for HBV and HCV patients than NAFLD. NAFLD represents a concerning insidious disease and prevention of progression to cirrhosis in these patients could be monitored using more frequent referral for Fibroscan®.
User profiles for access to telecom services (1999)

This paper first gives a brief introduction to a number of technologies related to supporting user profiles. Then the issues which need to be considered when planning user profiles for access to telecom services are discussed in detail.
The Pseudomonas aeruginosa quorum‐sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, inhibits porcine arterial smooth muscle contraction (1999)

The Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) has been shown to suppress cytokine production in macrophages. We have examined the effect of OdDHL and related compounds on constrictor tone of porcine blood vessels. OdDHL (1-30 microM) caused a concentration-dependent inhibition of U46619-induced contractions of the coronary artery through a largely endothelium-independent mechanism, but was markedly less effective in the pulmonary artery. Quantitively similar effects to those produced by OdDHL were observed with N-(3-oxododecanoyl)-L-homocysteine thiolactone, a thiolactone derivative, while N-3-oxododecanamide, a lactone-free acyl analogue, possessed 1/3rd the potency as a vasorelaxant. Neither N-butanoyl-L-homoserine lactone nor L-homoserine lactone (up to 30 microM) were active. Our findings indicate that OdDHL inhibits vasoconstrictor tone of both pulmonary and coronary blood vessels from the pig. The vasorelaxant action of OdDHL appears to be primarily determined by the N-acyl chain length, with a minor contribution by the homoserine lactone moiety.
Mefloquine Is Active In Vitro and In Vivo againstMycobacterium aviumComplex (1999)

Despite the development of several agents, new classes of antimicrobials with activity against the Mycobacterium avium complex (MAC) are needed. Based on a broad screening of compounds, we found that mefloquine has MICs of 8 to 16 microg/ml by the BACTEC system and 16 microg/ml by broth microdilution for five MAC strains tested. An expansion of the screening with broth microdilution to 24 macrolide-susceptible strains and 6 macrolide-resistant strains determined that the MIC for all strains was 16 microg/ml. To determine the intracellular activity of mefloquine, U937 macrophage monolayers infected with MAC strain 101, 100, or 109 (serovars 1, 8, and 4) were treated with mefloquine daily, and the number of intracellular bacteria was quantitated after 4 days. Significant growth inhibition against the three MAC strains at concentrations greater than or equal to 10 microg/ml (P < 0.05) was obtained. Due to the encouraging anti-MAC activity, in vivo efficacy in beige mice infected with MAC 101 was evaluated. Animals were treated with 5, 10, 20, or 40 mg/kg of body weight daily, three times a week, twice a week, or once a week for 4 weeks, and bacteria were quantitated in blood, liver, and spleen. No toxicity was observed with any of the treatment regimens. Mefloquine had borderline bactericidal activity at a dosage of 40 mg/kg daily (100% inhibition compared with a 1-week control), and significant inhibition was obtained at dosages of 40 mg/kg three times a week, as well as 20 mg/kg daily. Mefloquine had no significant effect on bacteremia. A combination of mefloquine and ethambutol showed significantly more activity than did either drug alone in liver, spleen, and blood; the combination was also bactericidal against M. avium. Although safety is a potential concern, mefloquine and related compounds deserve further investigation as anti-MAC therapies.
Systematic study of azimuthal anisotropy in Cu + Cu and Au + Au collisions atsNN=62.4and 200 GeV (2015)

We have studied the dependence of azimuthal anisotropy ${v}_{2}$ for inclusive and identified charged hadrons in $\mathrm{Au}+\mathrm{Au}$ and $\mathrm{Cu}+\mathrm{Cu}$ collisions on collision energy, species, and centrality. The values of ${v}_{2}$ as a function of transverse momentum ${p}_{T}$ and centrality in $\mathrm{Au}+\mathrm{Au}$ collisions at $\sqrt{{s}_{{}_{\mathit{NN}}}}=200$ and 62.4 GeV are the same within uncertainties. However, in $\mathrm{Cu}+\mathrm{Cu}$ collisions we observe a decrease in ${v}_{2}$ values as the collision energy is reduced from 200 to 62.4 GeV. The decrease is larger in the more peripheral collisions. By examining both $\mathrm{Au}+\mathrm{Au}$ and $\mathrm{Cu}+\mathrm{Cu}$ collisions we find that ${v}_{2}$ depends both on eccentricity and the number of participants, ${N}_{\mathrm{part}}$. We observe that ${v}_{2}$ divided by eccentricity ($\ensuremath{\varepsilon}$) monotonically increases with ${N}_{\mathrm{part}}$ and scales as ${N}_{\mathrm{part}}^{1/3}$. The $\mathrm{Cu}+\mathrm{Cu}$ data at 62.4 GeV falls below the other scaled ${v}_{2}$ data. For identified hadrons, ${v}_{2}$ divided by the number of constituent quarks ${n}_{q}$ is independent of hadron species as a function of transverse kinetic energy $K{E}_{T}={m}_{T}\ensuremath{-}m$ between $0.1&lt;K{E}_{T}/{n}_{q}&lt;1$ GeV. Combining all of the above scaling and normalizations, we observe a near-universal scaling, with the exception of the $\mathrm{Cu}+\mathrm{Cu}$ data at 62.4 GeV, of ${v}_{2}/({n}_{q}\ifmmode\cdot\else\textperiodcentered\fi{}\ensuremath{\varepsilon}\ifmmode\cdot\else\textperiodcentered\fi{}{N}_{\mathrm{part}}^{1/3})$ vs $K{E}_{T}/{n}_{q}$ for all measured particles.
Religious Attendance and Health Behavior in Cross-National Perspective: The Role of Religious Context (2022)

Background A substantial body of evidence shows that individuals with higher levels of religious attendance are more likely to avoid risky health behaviors and adopt beneficial health behaviors. Yet, less is known about the extent to which these patterns vary across national context. Purpose The current study aims to examine how religious attendance is associated with health behavior cross-nationally. More importantly, it assesses the ways that country-level religiosity moderates this association. In this endeavor, the current study focuses on five health behaviors—smoking, drinking, eating fruit, eating vegetables, and participating in physical activity. Methods The current study uses multilevel modeling with data from the seventh round of the European Social Survey (2014). Results The multilevel analyses demonstrate that religious attendance is negatively associated with drinking and smoking whereas it is positively associated with eating fruit, eating vegetables, and participating in physical activity cross-nationally. In addition, religious context moderates these associations in a way that lends support to the moral communities thesis. Specifically, the negative association between religious attendance and smoking behavior is stronger in countries with higher levels of religiosity. In a similar vein, the positive association between religious attendance and participating in physical activity is stronger in countries with higher levels of religiosity. However, the positive association between religious attendance and eating fruit is weaker in countries with higher levels of religiosity, which runs counter to the moral communities thesis. Conclusions and Implications The results in the study suggest that religious attendance has beneficial effects on health behavior. By analyzing a large, cross-national dataset, the current study lays a firmer basis for the generalization that religious attendance may discourage negative health behavior and promote positive health behavior. In addition, the current study elaborates on this pattern by documenting the moderating role of national religious context. The findings in the study implicate the importance of considering national context in research on religious involvement and health behavior.
Control of an electrostrictive polymer actuator with no sensor (2003)

It is usual to use sensors for controlling an electrostrictive polymer (EP) actuator system. However, it may make the whole actuator system larger and more complex. Thus, it is quite difficult to use some sensors for building a simple and small EP actuator system. In this paper, a technique based on neural networks is proposed to control a simple EP actuator without any sensor. First, a closed loop controller with a sensor is applied to control this EP actuator and its data are measured. Then these data and the characteristics of EP polymers are used to train a neural network offline. The resultant neural network is applied to control a simple EP actuator with no sensor. The experimental data under the proposed technique are compared with those under the closed loop controller and its result is discussed.
Plants as a Potential Source of Acetylcholinesterase Inhibitors for Nutraceutical Therapy Disease (2021)

Acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer’s disease (AD). AChE hydrolyzes a neurotransmitter acetyl-choline in choline and acetate, which reduces the amount of acetylcholine. The inhibition of AChE has been studied for a long time not only for AD but also in anxiety treatment. There are some plants with an inhibitory effect on AChE that can be used as an adjuvant in AD in dietary supplements. Extracts from Cucurbita pepo L., Solanum melongena L., and Spinacia oleracea L. contain a considerable number of compounds with inhibition effect on AChE. Evernic acid, usnic acid, atranorin, and vulpinic acid are plant growth inhibitors from Umbilicaria esculenta. Thus, plants seem to be a potential alternative to become a valuable nutraceutical source for the preparation of functional food. The purpose of this chapter consists on describe a great variety of plants with the inhibitory effect on AChE and to provide a broad view of their applications. The fact that naturally occurring compounds from plants are a potential source of new inhibitors has led to the discovery of an essential number of secondary metabolites and plant extracts with the ability to inhibit the enzyme AChE.
An empirical investigation of concerns of everyday tracking and recording technologies (2008)

This paper presents an exploration and analysis of attitudes towards everyday tracking and recording technologies (e. g., credit cards, store loyalty cards, store video cameras). Interview participants reported being highly concerned with information privacy. At the same time, however, they also reported being significantly less concerned regarding the use of everyday technologies that have the capabilities to collect, process, and disseminate personal information. We present results from this study that both identify and begin to explain this discrepancy.
A Functionally Redundant Altimeter (1976)

A scheme to provide redundant sensor data in an automatic control system using the principle of functional redundancy is described. Normally there are three redundant radar altimeters used in the terminal phase of automatic landing of jet transport airplanes. This scheme replaces one of these altimeters with a data processing scheme based on a Kalman filter. The filter is driven by altitude rate and acceleration signals from the air data computer and vertical accelerometer. A special initialization technique employs the two altimeter signals. The feasibility of this scheme is indicated by tests in which data obtained from these several sensors during flight tests are used to drive the functionally redundant altimeter.
Feature of Parturient and Fetus. (1991)

of more anesthesiologists are needed in the management of labor, although anesthesia for c-section is more often than not is given by anesthesiologists in Japan at such a rather big institution as a university hospital. Anesthesiologists may be called for to give an epidural anesthesia at the start of labor or during an active labor after various system medications for balanced analgesia have been given. Presented here are 1) current status of analgesia and anesthesia during labor, 2) evaluation of the course of labor, and 3) diagnosis and management of fetal distress. I Current status of analgesia and anesthesia during labor at the university hospitals in Japan and other developed countries The total number of annual deliveries and c-section rate were examined to know the background of each university hospital in Japan, in USA, in United Kingdom, in West Germany, in East Germany,and in France (Fig 1). Fewer deliveries are noted at the university hospitals in Japan. It is at only one institution that more than 1500 deliveries are done annually. C-section rate in Japan, how-
ChemInform Abstract: Core—Shell AgNP@CeO2 Nanocomposite Catalyst for Highly Chemoselective Reductions of Unsaturated Aldehydes. (2013)

Abstract Different unsaturated aldehydes are hydrogenated by using the title nanocomposite (17 examples).
[Prevalence of metallo-beta-lactamase in carbapenem resistant Pseudomonas aeruginosa at a university hospital of Buenos Aires City]. (2006)

The present study was conducted to estimate the prevalence of metallo-beta-lactamases in 91 consecutive carbapenem resistant Pseudomonas aeruginosa isolates, recovered from inpatients at Hospital de Clínicas in Buenos Aires. Both, phenotypic and genotypic methods detected the presence of carbapenemases in 10 (11%) isolates, corresponding to VIM-11 in 7/10 and VIM-2 in the others. Codifying genes were all included in class 1 integrons, upstream genes coding for aminoglycoside modifying enzymes. One hundred percent sensitivity and specificity was achieved by the metallo-beta-lactamases phenotypic screening method using EDTA (1 micromol) disks in the Pseudomonas aeruginosa isolates included in this study. Sensitivity to aztreonam in carbapenem resistant isolates was suspicious of the presence of these enzymes.
Distinctive cellular and junctional dynamics independently regulate the rotation and elongation of the internal organ (2023)

Abstract Complex structures of organs are formed at high reproducibility, and deformations of epithelia play major roles in these processes. To acquire the intricate morphology, an epithelium simultaneously suffers multiple structural changes. For example, to form the left-right asymmetric structure of Drosophila embryonic hindgut, its epithelial tube concurrently rotates and elongates, which are driven by cell sliding and convergent extension, respectively. However, how an epithelium simultaneously accomplishes multiple structural changes remains unclear. To address this issue, we here studied the relevancy between these two mechanisms in the hindgut morphogenesis. Our live imaging analysis revealed that Myosin1D and E -cad herin , or Par-3 are required only for cell sliding or convergent extension, respectively, while Myosin II is essential for both. Mathematical models showed that these cellular dynamics share a single mechanical system in the same time window. Such specificity and universality of the machineries controlling epithelial dynamics might be a general strategy adopted in complex tissue morphogenesis.
High Electron Drift Mobility in an Amorphous Film of 2,4,6,-Tris[4-(1-naphthyl)phenyl]-1,3,5-triazine (2004)

Abstract 2,4,6-Tris[4-(1-naphthyl)phenyl]-1,3,5-triazine exhibited a high electron drift mobility of 8.0 × 10−4 cm2 V−1 s−1.
Modeling Ethylene/Methyl Methacrylate and Ethylene/Methacrylic Acid Copolymers Using Acyclic Diene Metathesis Chemistry (2004)

The synthesis, characterization, and thermal behavior of ADMET models of ethylene/methyl methacrylate (EMMA) and ethylene/methacrylic acid (EMAA) copolymers are described. These model copolymers exhibit sharper melting transitions and lower melting points relative to random copolymers made using chain-growth polymerization methods. The EMMA and EMAA model copolymers are compared with ADMET ethylene-based model copolymers reported previously, comparisons which support the earlier finding that melting points decrease with an increase in the steric bulk of the pendant group.
Cationic photopolymerization of polyfunctional 1‐propenyl ether systems (2001)

Abstract The cationic photopolymerization of trimethylolpropane tripropenyl ether (TPE), initiated by a diaryl iodonium salt, has been investigated. The influence of the presence of different alcoholic additives on the rates of photopolymerization and on the properties of the networks obtained has been studied. New 1‐propenyl ethers (trimethylolpropane dipropenyl ether (DPE) and its acetyl ester) were synthesized and employed as modifying agents in TPE photopolymerization. The thermal and dynamic‐mechanical properties of the films obtained have been investigated and are correlated with the structure of the networks and to the mechanism of the curing reaction; a microheterogeneous structure of the network was shown by dynamic‐mechanical thermal analysis. © 2001 Society of Chemical Industry
Novel Approach for Designing a Low Weight Hip Implant Used in Total Hip Arthroplasty Adopting Skeletal Design Techniques (2011)

Aseptic loosening is the major cause of failure of hip implants after total hip arthroplasty. Stress shielding of the femur is known to be the principal factor involved in the aseptic loosening of hip implants. Solid stems are found to have a greater rigidity; therefore, they transfer less load proximally, which results in greater stress shielding of the proximal femur. A stem of low stiffness alone would not suffice in achieving a reduced or optimal stress shielding. The femoral stem of the light weight hip implant has a skeletal design with a hexagonal base and neck cross-section. This novel design would ameliorate the implant fixation, aid in optimal rigidity, enhance the medullary revascularization, and offer better mobility to the patient.