gebhart/patrepeval huggingface dataset:
Segregation of mitochondrial DNA mutations in the human placenta: implication for prenatal diagnosis of mtDNA disorders (2017)

These data indicate that (1) mutant load determined from CVS has to be interpreted with caution for PND of some mtDNA disorders and should be associated with/substituted by a mutant load measurement on amniocytes; (2) the m.3243A>G mutation behaves differently from other mtDNA mutations with respect to the impact on mtDNA copy number, as previously shown in human preimplantation embryogenesis.
A proposed concept for a crustal dynamics information management network (1980)

The findings of a requirements and feasibility analysis of the present and potential producers, users, and repositories of space-derived geodetic information are summarized. A proposed concept is presented for a crustal dynamics information management network that would apply state of the art concepts of information management technology to meet the expanding needs of the producers, users, and archivists of this geodetic information.
Synthesis and Blood Compatibility of Fluorinated Polyurethane Elastomer (2014)

In this paper, for the purpose of improving the hemocompatibility and surface tension of thermoplastic polyurethane (TPU) elastomers, poly butylene glycol ether hexafluoride fluoride ether glycol (PF) mixture with polytetramethylene ether glycol (PTMEG) was used as soft segments to synthesize a series of fluorinated thermoplastic polyurethane elastomers (FTPU) by two-step polymerization. The hemocompatibility in vitro was evaluated with platelet-rich plasma (PRP) contact tests. It was found that almost no platelet adhesion and activation was observed on the surface of FTPU elastomer when fluorine content was above 6wt% because of its low surface energy. The results indicated that fluorinated chain can be easily enriched on the surface of films because of higher C-F bond energy which due to greater micro-phase separation.
Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study (2011)

Within its limitations, the present study has indicated that (i) both treatment procedures resulted in comparable but limited CAL gains at 6 months, and (ii) OHI+AAD was associated with significantly higher BOP reductions than OHI+MDA.
Logic Gates Implementation with Coupled Oscillators (2018)

The rapid request increase for computing resources is leading to explore novel and often intriguing computing architectures. Among them, coupled oscillators have been rediscovered as a potential “beyond Moore” solution for several applications. We discuss in this work the realization of a complete set of logic gates (NOT and MAJORITY operators) as well as an inverter and a register employing coupled RLC oscillators with non-linear (cubic) resistance. The simple design allows for both analytical and numerical analysis, and it is ultimately realizable as discrete component hardware for testing purposes. It represents a simple tool to explore applications involving new computing paradigms.
A novel pilot protection scheme for distribution network with DGs (2014)

With the rapid interconnection of a large number of distributed generations(DGs), new challenges for protection of distribution network are posed. Three-section current protection will be no longer applied due to the change of structure of distribution network. To date, the majority of the solutions are adding directional elements or using differential protection scheme of high-voltage transmission. The former requires additional voltage transformer, the latter requires communication channel of high synchronization. However, that can not be realized in distribution network of low voltage. In allusion to the low voltage distribution network (weak communication, lacks of enough voltage transformer), this paper proposes a novel pilot protection scheme based on positive sequence current phase. Firstly, phase variation is obtained by compare the phase of sequence current before and after fault. Then, internal fault and external fault can be determined by compare phase variation of two terminals. Compared with traditional phase comparison pilot protection, this scheme only needs to transmit numerical value of phase variation, therefore communication channel of high synchronization is not required; compared with the traditional directional comparison pilot protection, this scheme only needs to collect current information, therefore there is no need for additional voltage transformer. Simulation proves the validity and superiority of proposed pilot protection scheme.
Photocrystallography and IR spectroscopy of light-induced linkage NO isomers in [RuBr(NO)2(PCyp3)2]BF4 (2015)

One single photo-induced linkage NO isomer (PLI) is detected and characterized in the dinitrosyl pentacoordinated compound [RuBr(NO)2(PCyp3)2]BF4 by a combination of photocrystallographic and IR analysis. In the ground state, the molecule adopts a trigonal-bipyramidal structure with the two NO ligands almost linear with angles Ru-N1-O1 = 168.92 (16), Ru-N2-O2 = 166.64 (16)°, and exactly equal distances of Ru-N = 1.7838 (17) and O-N = 1.158 (2) Å. After light irradiation of 405 nm at T = 10 K, the angle of Ru-N2-O2 changes to 114.2 (6)° by rotation of the O atom towards the Br ligand with increased distances of Ru-N2 = 1.992 (6) and N2-O2 = 1.184 (8) Å, forming a bent κN bonded configuration. Using IR spectroscopy, the optimal wavelength and maximum population of 39 (1)% of the PLI is determined. In the ground state (GS), the two symmetric νs(NO) and asymmetric νas(NO) vibrations are measured at 1820 and 1778 cm(-1), respectively. Upon photo-irradiation, the detection of only one new vibrational ν(NO) stretching band at 1655 cm(-1), assigned to the antisymmetric coupled vibration mode and shifted to lower wavenumbers by -123 cm(-1), supports the photocrystallographic result. These experimental results are supported by additional DFT calculations, which reproduce the structural parameters and vibrational properties of both the ground state and the photo-induced linkage isomer well. Especially the experimentally characterized molecular structure of the PLI state corresponds to an energy minimum in the calculations; the stabilization of the bent κN bonded configuration of the PLI state originates from specific intramolecular orbital overlap.
Differences Between Study‐Specific and Subject‐Specific Heart Rate Corrections of the QT Interval in Investigations of Drug Induced QTc Prolongation (2004)

A computational study was designed to investigate the differences between the so-called study-specific and subject-specific heart rate corrections of QT interval. In 53 healthy subjects (25 women, mean age 26.7 +/- 8.7 years), serial 10-second electrocardiograms (ECG) were obtained during daytime hours. In each subject, 200 ECGs were selected representative of the individual QT/RR relationship. Of the population of 53 subjects, 30,000 different subgroups of 16 subjects were considered and their data used to model drug induced QT interval prolongation by 0, 5, 10, and 20 ms combined with drug induced heart rate acceleration and deceleration. In each modeled study, QTc changes were assessed by: (1) Six study-specific heart rate corrections designed by regression modeling of the baseline QT/RR data pooled from all subjects; (2) Six subject-specific heart rate corrections designed by the same regression modeling of the baseline QT/RR data in each subject separately; (3) subject optimized correction that selected the best fitting regression model for each individual; and (4) by Bazett and Fridericia corrections. In each modeled study, the errors of the correction approaches were estimated and statistically summarized over all modeled studies. The subject-specific corrections led to maximum errors in single milliseconds (error range of 2.4, 5.7, and 2.6 ms with linear, log/log linear, and exponential models, respectively) while the study-specific corrections led to substantially greater errors (error range of 17.8, 19.4, and 16.9 ms with linear, log/log linear, and exponential models, respectively). Both Bazett and Fridericia corrections led not only to substantial errors (error range of 28.3 and 16.9 ms) but also to regular bias with systematically false negative and false positive conclusions dependent on modeled heart rate acceleration and deceleration. Thus, subjects-specific corrections should be used in the intensive and definite studies aimed at providing the final answer on the ability of a drug to prolong the QT interval.
Telematic Tubs Against Terror: Bathing in the Immersive Interactive Media of the Post-Cyborg Age (2004)

October 01 2004 Telematic Tubs Against Terror: Bathing in the Immersive Interactive Media of the Post-Cyborg Age Steve Mann Steve Mann University of Toronto, 10 King's College Road, Dept. ECE, Mailstop SFB540, Toronto, Ontario, Canada. E-mail: mann@eecg. toronto.edu. Search for other works by this author on: This Site Google Scholar Author and Article Information Steve Mann University of Toronto, 10 King's College Road, Dept. ECE, Mailstop SFB540, Toronto, Ontario, Canada. E-mail: mann@eecg. toronto.edu. Online Issn: 1530-9282 Print Issn: 0024-094X © 2004 ISAST2004 Leonardo (2004) 37 (5): 372–373. https://doi.org/10.1162/0024094041956024 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Steve Mann; Telematic Tubs Against Terror: Bathing in the Immersive Interactive Media of the Post-Cyborg Age. Leonardo 2004; 37 (5): 372–373. doi: https://doi.org/10.1162/0024094041956024 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsLeonardo Search Advanced Search This content is only available as a PDF. © 2004 ISAST2004 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of heat denaturation of bovine milk beta-lactoglobulin on its epithelial transport and allergenicity (2006)

Beta-lactoglobulin (β-lg) is the main whey protein in bovine milk. It belongs to the lipocalin protein family, and it is one of the main milk allergens. Resistance to hydrolysis is a particular feature of βlg making it possible that β-lg reaches the small intestine in its native form. Heat treatments during milk processing may change the native structure of bovine β-lg and change its intestinal transport properties. Heat induced conformational alterations may also expose new antigenic sites. However, there have been no previous studies on the effects of heat treatment on the transport of β-lg or on its sensitizing properties. Cow's milk allergy is one of the most important food allergies affecting about 2.4% of infants. Milk proteins, including β-lg, in breast milk substitute formulas are often the earliest foreign antigens in the diet of newborns. According to the hygiene hypothesis, natural infections and vaccinations may modify the immunological balance and decrease the risk of allergy. Isoelectric precipitations followed by anion exchange and gel filtration were used to purify bovine milk β-lg in its native form. Transport of native and heat-denatured β-lg was compared in two in vitro cell models, Caco-2 and M-cells. Sensitization properties of native and heat-denatured β-lg were studied with an animal model using Hooded-Lister rats. Effects of BCG vaccination in combination with the native β-lg were also studied. Effects of different sensitizations were assessed by antibody levels in serum and inflammation locally in the gastrointestinal tract. Heat denaturation of β-lg made its transport slower in both enterocytes and M-cells. M-cells were more effective transporters of both native and heat-denatured β-lg than caco-2 cells. Animals generated higher levels of IgE when sensitized with native β-lg, but heat-denatured β-lg induced a more intense inflammatory cell reaction in the gastrointestinal tract. Vaccination with BCG decreased serum IgE concentration and modified the predominant site of the inflammatory cell response in intestine. The results indicate that, heat denaturation of β-lg and BCG vaccination, change both the systemic and the mucosal response to bovine milk β-lg. The reasons for this remain speculative. The effect of BCG vaccination is consistent with the hygiene hypothesis. The observed alteration of transport properties could be one mechanism by which heat denaturation modifies the allergenic properties of this protein, but additional studies are necessary to assess whether other mechanisms, such as exposure of new antigenic determinants are also relevant.
Disposable Amperometric Immunosensor for the Determination of Human P53 Protein in Cell Lysates Using Magnetic Micro-Carriers (2016)

An amperometric magnetoimmunosensor for the determination of human p53 protein is described in this work using a sandwich configuration involving the covalent immobilization of a specific capture antibody onto activated carboxylic-modified magnetic beads (HOOC-MBs) and incubation of the modified MBs with a mixture of the target protein and horseradish peroxidase-labeled antibody (HRP-anti-p53). The resulting modified MBs are captured by a magnet placed under the surface of a disposable carbon screen-printed electrode (SPCE) and the amperometric responses are measured at -0.20 V (vs. an Ag pseudo-reference electrode), upon addition of hydroquinone (HQ) as a redox mediator and H₂O₂ as the enzyme substrate. The magnetoimmunosensing platform was successfully applied for the detection of p53 protein in different cell lysates without any matrix effect after a simple sample dilution. The results correlated accurately with those provided by a commercial ELISA kit, thus confirming the immunosensor as an attractive alternative for rapid and simple determination of this protein using portable and affordable instrumentation.
Heat Transfer - Engineering Applications (2011)

Heat transfer is involved in numerous industrial technologies. This interdisciplinary book comprises 16 chapters dealing with combined action of heat transfer and concomitant processes. Five chapters of its first section discuss heat effects due to laser, ion and plasma-solid interaction. In eight chapters of the second section engineering applications of heat conduction equations to the curing reaction kinetics in manufacturing process, their combination with mass transport or ohmic and dielectric losses, heat conduction in metallic porous media and power cables are considered. Analysis of the safety of mine hoist under influence of heat produced by mechanical friction, heat transfer in boilers and internal combustion engine chambers, management for ultrahigh strength steel manufacturing are described in this section as well. Three chapters of the last third section are devoted to air cooling of electronic devices.
Animating to Build Higher Cognitive Understanding: A Model for Studying Multimedia Effectiveness in Education* (2004)

Abstract This paper presents a model for designing experiments to test the effectiveness of multimedia and other technological enhancements in education. It is based upon a discussion of an experimental study that examined the impact of one specific multimedia enhancement—animation—on a very specific aspect of learning—the ability to apply knowledge, for a well‐defined population—adult, continuing education students, in a highly specified knowledge domain–Boolean algebra. The paucity of substantial evidence supporting the value of multimedia as an educational enhancement can at least partially be attributed to definitional problems within experimental designs. What specifically does “learning,” and, for that matter, “multimedia”, mean? If these terms are not explicitly defined and intimately incorporated into the experimental controls, there is little hope for creditable results. This study indicates that careful attention to defining these two terms can produce meaningful results.
Status of IVHS technical developments in the United States (2003)

The authors address the state of domestic technical developments in the five components of intelligent vehicle highway systems (IVHS): advanced traffic management systems (ATMS), advanced traveler information systems (ATIS), advanced vehicle control systems (AVCS), commercial vehicle operations (CVO), and advanced public transportation systems (APTS). Each component and current operational tests are briefly described. Particular emphasis is given to three current large-scale operational field tests (Pathfinder, TravTek, and ADVANCE) to illustrate the integration of the IVHS components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of electric fields on long-wavelength response of infra-red detectors (1983)

The effect of electric fields on extrinsic semiconductor infrared-detector response at low temperatures is examined quantitatively at wavelengths beyond the zero-field cutoff. General formulas are presented along with numerical results for Si:P and Si:In. These results illustrate the possibility of narrow-bandwidth detection and electronically modulated response.
Collagen model peptides: Sequence dependence of triple-helix stability (2000)

The triple helix is a specialized protein motif, found in all collagens as well as in noncollagenous proteins involved in host defense. Peptides will adopt a triple-helical conformation if the sequence contains its characteristic features of Gly as every third residue and a high content of Pro and Hyp residues. Such model peptides have proved amenable to structural studies by x-ray crystallography and NMR spectroscopy, suitable for thermodynamic and kinetic analysis, and a valuable tool in characterizing the binding activities of the collagen triple helix. A systematic approach to understanding the amino acid sequence dependence of the collagen triple helix has been initiated, based on a set of host-guest peptides of the form, (Gly-Pro-Hyp)(3)-Gly-X-Y-(Gly-Pro-Hyp)(4). Comparison of their thermal stabilities has led to a propensity scale for the X and Y positions, and the additivity of contributions of individual residues is now under investigation. The local and global stability of the collagen triple helix is normally modulated by the residues in the X and Y positions, with every third position occupied by Gly in fibril-forming collagens. However, in collagen diseases, such as osteogenesis imperfecta, a single Gly may be substituted by another residue. Host-guest studies where the Gly is replaced by various amino acids suggest that the identity of the residue in the Gly position affects the degree of destabilization and the clinical severity of the disease.
ETDD-based synthesis of term-based FPGAs for incompletely specified Boolean functions (2002)

Complex terms are logic expressions which can be mapped directly to cell arrays of cellular architecture devices such as Atmel 6000 series FPGAs. This paper presents an approach to generation of complex terms for incompletely specified Boolean functions using ETDD (EXOR Ternary Decision Diagram)s. Basically the decompositions, Shannon, positive Davio and negative Davio, inherent in ETDDs are employed to generate complex terms. While traversing the ETDD can be done in a simple and efficient way for completely specified functions, the manipulation of ETDDs with don't care terms becomes very complex because the three decompositions require different evaluations of the function. The changes made to the function due to don't cares in each decomposition are analyzed and an approximation algorithm is presented with its applications to the synthesis of complex terms.
Influence of the organic film thickness on the second order distributed feedback resonator properties of an organic semiconductor laser (2017)

We report on the cavity numerical characterization of a second order one-dimensional distributed feedback organic laser. The gain medium containing 6 wt. % of 4,4′-bis[(N-carbazole)styryl]biphenyl) in a 4,4′-bis[9-dicarbazolyl]-2,2′-biphenyl) host is vacuum deposited to form an organic thin film on a SiO2 grating. The influence of the organic film thickness on the properties of the resonant cavity is investigated through numerical calculations of both the confinement factor Γ and the Q-factor. The Q-factor is obtained using two methods, one by calculating the eigenmodes of the resonant cavity and the other by calculating the reflection spectrum. It was found that while the Γ increases with the organic film thickness, the Q-factor shows a non-monotonic function with a maximum value for a thickness of 200 nm.
Design of a wearable wide-angle projective color display (2002)

Purpose: We investigate the design and fabrication of ultra-light weight projection lenses for color wearable displays.Methods: Driven by field of view requirements from 40 degree to 90 degrees, plastic, glass, and diffractive optics are combined to yield &lt;10g per eye. The approach centers on the use of projection optics instead of eyepiece optics to yield most compact and high image quality designs.Results: We completed the design and fabrication of an 8g, 52 degree lens. The polychromatic MTF holds well over the entire field of view with a 20% modulation at 55cycles/mm or equivalently 1.8 arcmin resolution over a 3 mm pupil size. Over a 12 mm pupil size the polychromatic MTF still holds well over the entire field of view reaching 10% modulation at 38cycles/arcmin. The implementation of the fabricated 52 degrees lens in a teleportal head-mounted display and remote collaborative environment will be demonstrated. We shall also present design results for a 70degrees design.Conclusion: Projection optics offers unique solutions for compact light-weight designs for wearable displays. Furthermore, it offers the unique capability to scale field of view to large angles in the order of 70 degrees without cubic scaling of the weight of the optics as a consequence.
PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS). (2004)

Human epidemiological studies suggest an association between N-acetyltransferase (NAT) activity and the incidence of bladder and colorectal cancers. In this study, paclitaxel was selected to examine the inhibition of arylamine NAT activity, gene expression and 2-aminofluorene-DNA adduct formation in a human osteogenic sarcoma cell line (U-2 OS). The activity of NAT was determined by high performance liquid chromatography (HPLC) assay for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and nonacetylated AF and PABA. Human osteogenic sarcoma cell cytosols and intact cells were used to examine the NAT activity, gene expression and AF-DNA adduct formation. The results demonstrated that NAT activity percent of NAT in examined cells, gene expression (NAT1 mRNA) and AF-DNA adduct formation in human osteogenic sarcoma cells were inhibited and decreased by paclitaxel in a dose-dependent manner. The results also demonstrated that paclitaxel decreased the apparent values of Km and Vmax from intact human osteogenic sarcoma cells (U-2 OS). Thus, paclitaxel is an uncompetitive inhibitor of the NAT enzyme.
DeepDTA: deep drug–target binding affinity prediction (2018)

Supplementary data are available at Bioinformatics online.