gebhart/patrepeval huggingface dataset:
DNA damage by ptaquiloside, a potent bracken carcinogen: detection of selective strand breaks and identification of DNA cleavage products (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDNA damage by ptaquiloside, a potent bracken carcinogen: detection of selective strand breaks and identification of DNA cleavage productsTatsushi Kushida, Motonari Uesugi, Yukio Sugiura, Hideo Kigoshi, Hideyuki Tanaka, Junichi Hirokawa, Makoto Ojika, and Kiyoyuki YamadaCite this: J. Am. Chem. Soc. 1994, 116, 2, 479–486Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ja00081a007https://doi.org/10.1021/ja00081a007research-articleACS PublicationsRequest reuse permissionsArticle Views344Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Efficient Solar Cells from Metallurgical-Grade Silicon (1980)

In order to examine the possibility of utilizing metallurgical-grade silicon (MG-Si) for terrestrial photovoltaic use, solar cells are fabricated either by epitaxial growth or by direct diffusion on a substrate which is obtained by Czochralski crystallization conducted once or twice. Even by single crystallization of this material it is possible to obtain 10% efficiency if a 50 µm active layer is grown on the substrate crystal. A 10.5% (11.9% on the active area) cell is realized for the case where this material is subjected to acid-leaching prior to crystallization. A conversion efficiency as high as 8.5% is obtained for a directly diffused cell when a proper gettering process is applied.
Effects of sex steroids on regulation of the levels of Cl peptide of rat prostatic steroid-binding protein mRNA evaluated by in-situ hybridization (1988)

Prostatic steroid-binding protein (PBP) is the most abundant protein synthesized in the rat ventral prostate. The protein is under strict androgenic control and is made of two subunits containing the polypeptides C1, C2 and C3. Using an 35S-labelled cDNA probe, we have used quantitative in-situ hybridization to assess the regulation of polypeptide C1 mRNA levels by sex steroids in the adult male rat. Densitometric quantification of autoradiographic hybridization signals revealed that a significant decrease in C1 mRNA levels could be detected 5 h after castration. Levels of C1 mRNA decreased by 50% 2.5 days after castration, while undetectable levels were reached within 7 days. Administration of the potent androgen 5 alpha-dihydrotestosterone to castrated rats caused a progressive increase in C1 mRNA levels which became significant 5 h after the first injection, while prolonged treatment, for 3 and 7 days, caused 50 and 100% reversals respectively of the effect of castration on C1 mRNA levels. Similar results were obtained by dot-blot hybridization using the same 32P-labelled cDNA probe, thus confirming the specificity and quantification achieved by in-situ hybridization. Administration of oestradiol-17 beta to orchiectomized adult rats for 14 days had no effect on steady-state C1 mRNA levels. Progesterone, on the other hand, at the dose used (2 mg twice daily) caused a marked increase in C1 mRNA levels, measured by in-situ hybridization, which was completely reversed by concomitant administration of the pure antiandrogen flutamide. The present data clearly demonstrate that the expression of PBP C1 peptide mRNA is under strict androgenic control and is a very sensitive and specific parameter of androgenic activity. They also indicate that quantitative in-situ hybridization is a powerful, sensitive and most efficient tool to study the regulation of gene expression while, in addition, providing precise information about the site of mRNA localization as well as information about the histology of the tissue, particularly the heterogeneous nature of the acinar response to androgenic stimulation and deprivation.
Plasmonic effects of ultra-thin Mo films on hydrogenated amorphous Si photovoltaic cells (2012)

We report on the improvement of short circuit current (JSC), fill factor (FF), and open circuit resistance (ROC) in hydrogenated amorphous silicon (a-Si:H) photovoltaic cells with a p-type/intrinsic/n-type structure, achieved by the addition of an ultra-thin molybdenum film between the p-type film and the transparent conductive oxide/glass substrate. For suitable conditions, improvements of ≈10% in average internal quantum efficiency and up to 5%–10% under standard illumination in JSC, FF, and ROC are observed. These are attributed to the excitation of surface plasmon polariton modes of the a-Si:H/Mo interface.
Actin polymerization in neutrophils. Cell density, molecular redistribution, and mass transfer rate-factors in response dynamics. (1995)

Regulation of cellular responses to stimulation is one of the major areas in contemporary biology. I studied regulation of the actin polymerization response in neutrophils stimulated by chemotactic peptides. Actin polymerization in neutrophils, as well as in many other cell types, is essential for polarization, motility, chemotaxis, and phagocytosis. I investigated the relationship between the actin response dynamics and distribution of the eliciting receptors and actin within the cell. I developed a method to visualize both receptors and F-actin in the same cell and showed that in polarized neutrophils the receptor and F-actin distributions do not coincide. Based on this finding, I proposed a novel mechanism of response regulation by translocation of signalling molecules within the cell. I also demonstrated the importance of extracellular chemical factors in response termination; I showed that a rapid termination of the response to high concentrations of chemoattractants is a result of ligand loss and inhibition by endogenously produced factors in the medium. By keeping cells in a diluted suspension or by exchanging the medium, I was able to stimulate sustained actin polymerization. The binding rate of the agonist is another factor that can influence the response kinetics. With sufficiently numerous and high-affinity receptors on the cell surface, binding can be diffusion-limited. However, the conditions determining whether the reaction is diffusion-limited have been formulated for stationary liquid only, whereas experiments with cell suspensions are usually done with stirring. Therefore I did a theoretical analysis of the effect of stirring (it can be a different kind of convective transport as well) on the kinetics of ligand-receptor interactions. I also considered another practically important case: binding kinetics to cells forming a monolayer on a surface, with or without perfusion. My theoretical results may help experimentalists correctly perform measurements of the rates of ligand-receptor interactions.
LD-pumped slab Yb:YAG laser (2000)

In recent years, the high power Yb:YAG lasers have been actively investigated due to the advantage of the high quantum efficiency of 91% which reduces the thermal loading in the Yb:YAG crystal. So far, the Yb:YAG laser with the output power higher than several hundreds watts has been developed using the crystal configurations of rod and thin disk. We have developed the Yb:YAG laser by employing the rectangular slab crystal in order to examine the possibility of realizing the high power slab Yb:YAG laser. The dimension of the Yb:YAG crystal used is 1 mm X 5 mm X 10 mm and its configuration is a rectangular parallelepiped, and the density of Yb is 1.1 atom%. The LD (Laser Diode) pump light focused with plano-convex lens is introduced through the 1 mm X 10 mm plane of this slab which is AR-coated at 940 nm while the opposite 1 mm X 10 mm plane is HR-coated at the same wavelength. The Yb:YAG laser cavity axis is in the direction perpendicular to the 1 mm X 5 mm planes which are AR-coated at 1030 nm. The two 5 mm X 10 mm planes are cooled by being contacted with the copper heat sinks which are cooled by the water at the temperature of 18 degrees Celsius. The CW output of 35 W was obtained when the power of LD pump light was 496 W. The optical efficiency was 7.1% with the optical slop efficiency of 12.2%.
Eplerenone in patients with systolic heart failure and mild symptoms : analysis of repeat hospitalisations (2012)

Risk of stroke, systemic embolism or death according to heart failure and left ventricular function status in patients with atrial fibrillation : results of the ARISTOTLE trial
Etat des lieux de la cartographie du génome du porc (1999)

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access
Halo antenna with cylindrical conductor for space of feed circuits (2011)

Slim and lightweight base station antennas are required in the next wireless communication systems to achieve low construction cost. Authors have investigated Halo antenna with parasitic element as a slim omni-directional horizontal-polarization antenna in past research. Halo antenna has symmetrical and cylindrical configuration and feed circuits should be inserted in the symmetrical plane to avoid impedance shift and pattern distortion. Thus Halo antenna has difficulties achieving high gain and beam tilt functionality because the feed circuits for high gain antennas and beam tilting antennas must be large and complex. In this paper, a cylindrical conductor for electrostatic shielding effects is inserted in Halo antenna, and the feed circuits are inserted in the cylindrical conductor without any effects on the antenna performance. The pattern distortion due to scattering current on the cylindrical conductor is canceled out by the symmetrical flow of scattering currents, thus, the cylindrical conductor is also inserted in Halo antenna without pattern distortion. The impedance and bandwidth of the Halo antenna depends on the size of cylindrical conductor. The numerical results, obtained by changing the size of cylindrical conductor, verified more than 1/3 space in Halo antenna can be assigned for feed circuits.
Reactivating Memories during Sleep by Odors: Odor Specificity and Associated Changes in Sleep Oscillations (2014)

Memories are reactivated during sleep. Re-exposure to olfactory cues during sleep triggers this reactivation and improves later recall performance. Here, we tested if the effects of odor-induced memory reactivations are odor-specific, that is, requiring the same odor during learning and subsequent sleep. We also tested whether odor-induced memory reactivation affects oscillatory EEG activity during sleep, as a putative mechanism underlying memory processing during sleep. Participants learned a visuospatial memory task under the presence of an odor. During subsequent SWS, the same odor, a different odor, or an odorless vehicle was presented. We found that odor re-exposure during sleep significantly improves memory only when the same odor was presented again, whereas exposure to a new odor or the odorless vehicle had no effect. The memory-enhancing effect of the congruent odor was accompanied by significant increases in frontal delta (1.5-4.5 Hz) and parietal fast spindle (13.0-15.0 Hz) power as well as by an increased negative-to-positive slope of the frontal slow oscillation. Our results indicate that odor-induced memory reactivations are odor specific and trigger changes in slow-wave and spindle power possibly reflecting a bottom-up influence of hippocampal memory replay on cortical slow oscillations as well as thalamo-cortical sleep spindles.
Comparing Stochastic Approaches to Spoken Language Understanding in Multiple Languages (2010)

One of the first steps in building a spoken language understanding (SLU) module for dialogue systems is the extraction of flat concepts out of a given word sequence, usually provided by an automatic speech recognition (ASR) system. In this paper, six different modeling approaches are investigated to tackle the task of concept tagging. These methods include classical, well-known generative and discriminative methods like Finite State Transducers (FSTs), Statistical Machine Translation (SMT), Maximum Entropy Markov Models (MEMMs), or Support Vector Machines (SVMs) as well as techniques recently applied to natural language processing such as Conditional Random Fields (CRFs) or Dynamic Bayesian Networks (DBNs). Following a detailed description of the models, experimental and comparative results are presented on three corpora in different languages and with different complexity. The French MEDIA corpus has already been exploited during an evaluation campaign and so a direct comparison with existing benchmarks is possible. Recently collected Italian and Polish corpora are used to test the robustness and portability of the modeling approaches. For all tasks, manual transcriptions as well as ASR inputs are considered. Additionally to single systems, methods for system combination are investigated. The best performing model on all tasks is based on conditional random fields. On the MEDIA evaluation corpus, a concept error rate of 12.6% could be achieved. Here, additionally to attribute names, attribute values have been extracted using a combination of a rule-based and a statistical approach. Applying system combination using weighted ROVER with all six systems, the concept error rate (CER) drops to 12.0%.
The Use of Capacitance Sensors for Phase Percentage Determination in Multiphase Pipelines (1980)

A variety of capacitance designs are considered for determining the volume fractions in two-phase pipelines. Experimental results are compared for the most promising structures and for slug (SL) and stratified (ST) flow patterns. It is concluded that the most practical linear sensor is the double helix capacitance, although in some instances a four concave-plate structure may be preferred for greater sensitivity and simplicity of construction if the flow pattern is known.
Intracisternal A Particle Formation and Inhibition in Preimplantation Mouse Embryos (1975)

Intracisternal A particles (IAP) appear in large numbers at approximately the 4 cell stage in murine development. Many cytoplasmic regions containing a few complete IAP’s and budding lAP’s are recognizable in the 2 cell—early 4 cell stages. Zygotes cultured to the 2 cell stage show regions interpreted as earlier stages in IAP formation. These cytoplasmic regions are characterized by fibrous material outlining agranular cisternae of the endoplasmic reticulum, 20 nm granule aggregations and occasionally show IAP budding into the endoplasmic reticulum. These presumptive IAP regions are also seen in zygotes cultured to the 2 cell stage in α-amanitin but are not present in embryos cultured in actinomycin D. This sensitivity to actinomycin D further underscores the similarities between IAP and mouse oncornaviruses.
A Novel Ambipolar Spirobifluorene Derivative that Behaves as an Efficient Blue-Light Emitter in Organic Light-Emitting Diodes (2007)

A novel ambipolar spiro-configured D-A blue-light emitter bearing hole-transporting diphenylamino groups and electron-transporting phenylbenzimidazole groups was synthesized, characterized, and incorporated into an efficient single-layer organic light-emitting diode (OLED) device exhibiting blue-emission Commission International d'Eclairage (CIE) coordinates of 0.15 and 0.14, a turn-on potential of 4 V, a maximum brightness of 2800 cd/m2 at 830 mA/cm2 (19 V), and a maximum quantum efficiency of 0.53% (0.61 cd/A).
Mechanical behavior of microstructures from a chemo-responsive polymer nanocomposite based on cotton cellulose nanofibers (2011)

This paper reports on the fabrication and characterization of MEMS-scale devices from a mechanically dynamic polymer nanocomposite, consisting of a cotton-derived cellulose nanofibers encased in a poly(vinyl acetate) matrix, with a stiffness modulated by the presence or absence of water. Microtensile testing showed that the Young's modulus (E) of the nanocomposite is initially ~2.7 GPa, but reduces to ~4 MPa upon immersion in water for 7 minutes. A combination of laser-micromachining and lithographic processing was used to produce an intracortical probe with switchable stiffness based on the dynamic nanocomposite. An electrode with area 2800 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> was found to have an impedance of 156 kΩ at 1 kHz. This investigation was the first time that a chemoresponsive nanocomposite based on cotton cellulose nanofibers was used in MEMS-scale structures.
A 0.8-1.2GHz Single-Phase Resonant-Clocked FIR Filter with Level-Sensitive Latches (2007)

In this paper, we present the design and experimental validation of RF1, a 0.8-1.2GHz frequency-scalable, resonant-clocked FIR filter test-chip with level-sensitive latches. Designed using a fully automated ASIC flow, RF1 was fabricated in a 0.13 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</i> m CMOS process with an on-chip inductor and clock generator. At its resonant frequency of 1.03GHz, RF1 dissipates 132mW, with clock power accounting for only 10.8% of total power dissipation. Resonating 42pF of clock load, RF1 achieves 76% clock-power efficiency over CV <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> .
Impact of Water on PEFC Performance Evaluated by Neutron Imaging Combined with Pulsed Helox Operation (2012)

A novel experimental method for the measurement of mass transport losses in a polymer electrolyte fuel cell (PEFC) was developed, based on the comparison of cell voltage during operation with air, helox, (79% He, 21% O<sub>2</sub>) or pure O<sub>2</sub>. Using only short periods (2 seconds) of helox or pure O<sub>2</sub> operation, the disturbing artifacts (dry out or change of catalyst surface oxidation state) associated with continuous operation with these gases were avoided. High resolution neutron imaging was conducted simultaneously in order to study the relation between mass transport loss and liquid water accumulation. For the studied design, comparisons in steady state and dynamic experiments indicated a larger impact of water accumulation in the gas diffusion layers (GDL) under the flow channels, or in the portion of the channels near the GDL surface. Increased diffusion losses were observed, as expected, under high humidity conditions, but also at very low humidity conditions in absence of any liquid water. The latter was explained by a redistribution of current toward the rib region, having longer diffusion paths.
A multi-scaled analysis of forest structure using individual-based modeling in a costa rican rainforest (2020)

Consideration of scale is essential when examining structural relationships in forests. In this study, we present a parameterization of the FORMIND individual-based forest model for old growth Atlantic lowland rainforest in La Selva, Costa Rica. Results show that the simulated forest reproduces the structural complexity of Costa Rican rainforest within 2.3% of aboveground biomass values, based on comparisons with CARBONO inventory plot data. The Costa Rica FORMIND simulation was then used to investigate the relationship between canopy height and aboveground biomass (AGB), leaf area index (LAI) and gross primary productivity (GPP) at different spatial scales (20 × 20 m, 60 × 60 m, 100mx100m). The relationship between aboveground biomass and height is of particular importance toward the calibration of various remote sensing products including lidar and radar, whereas the LAI and GPP relationships are understudied in this context. We found that the relationship between all three variables and height varies considerably: the relationship is stronger at finer scales and weaker at coarser resolution. However, in all three comparisons, RMSE also decreased as scales coarsened, with the largest difference shown between 100 m and 10 m resolutions in relating AGB to Lorey's height (R2 decreased by 0.3; RMSE decreased by 114.5 Mg/ha). This suggests that a trade-off between accuracy and precision exists, and further highlights the importance of spatial scale in determining the relatability of forest structure variables.
A latency-proof quantization noise reduction method for digitally-controlled ring oscillators (2010)

This paper describes a quantization noise reduction method for ΔΣ based digitally-controlled ring oscillators (DCRO). A concept of the hybrid finite-impulse response (FIR) filter from the fractional-N PLL is extended to the DCRO design. Thanks to the parallel operation, the proposed filter based noise reduction method does not cause any additional latency to the digital PLL. Both behavioral and circuit-level simulations are performed, showing that out-of-band phase noise or short-term jitter caused by the ΔΣ modulator can be significantly reduced with the proposed method.
The Art of Social Justice (2022)

As this HJSR special issue on social justice unfolded, it became clear to the editorial team that this publication would be incomplete without addressing the well-documented role of art in social justice movements. We asked two of our managing editors, Jennifer Miles and Laura Dawson, to research and write about this area of social action. They interviewed two artists, a spoken word performer and a visual artist, both of whom understand their art as part of larger social justice projects. These artists raise awareness, highlight obstacles and avenues for change, and create space for solidarity and sanctuary. The following montage situates their artistry within their own biographies and a rich history of social change through art. Mary Virnoche and Jennifer Eichstedt, Editors.
Mechanism of action of probiotics (2013)

The modern diet doesn't provide the required amount of beneficial bacteria. Maintenance of a proper microbial ecology in the host is the main criteria to be met for a healthy growth. Probiotics are one such alternative that are supplemented to the host where by and large species of Lactobacillus, Bifidobacterium and Saccharomyces are considered as main probiotics. The field of probiotics has made stupendous strides though there is no major break through in the identification of their mechanism of action. They exert their activity primarily by strengthening the intestinal barrier and immunomodulation. The main objective of the study was to provide a deep insight into the effect of probiotics against the diseases, their applications and proposed mechanism of action.