gebhart/patrepeval huggingface dataset:
Loss of Heterozygosity on Chromosome 11q13 in Two Families with Acromegaly/Gigantism Is Independent of Mutations of the Multiple Endocrine Neoplasia Type I Gene1 (1999)

Familial acromegaly/gigantism occurring in the absence of multiple endocrine neoplasia type I (MEN-1) or the Carney complex has been reported in 18 families since the biochemical diagnosis of GH excess became available, and the genetic defect is unknown. In the present study we examined 2 unrelated families with isolated acromegaly/gigantism. In family A, 3 of 4 siblings were affected, with ages at diagnosis of 19, 21, and 23 yr. In family B, 5 of 13 siblings exhibited the phenotype and were diagnosed at 13, 15, 17, 17, and 24 yr of age. All 8 affected patients had elevated basal GH levels associated with high insulin-like growth factor I levels and/or nonsuppressible serum GH levels during an oral glucose tolerance test. GHRH levels were normal in affected members of family A. An invasive macroadenoma was found in 6 subjects, and a microadenoma was found in 1 subject from family B. The sequence of the GHRH receptor complementary DNA in 1 tumor from family A was normal. There was no history of consanguinity in either family, and the past medical history and laboratory results excluded MEN-1 and the Carney complex in all affected and unaffected screened subjects. Five of 8 subjects have undergone pituitary surgery to date, and paraffin-embedded pituitary blocks were available for analysis. Loss of heterozygosity on chromosome 11q13 was studied by comparing microsatellite polymorphisms of leukocyte and tumor DNA using PYGM (centromeric) and D11S527 (telomeric), markers closely linked to the MEN-1 tumor suppressor gene. All tumors exhibited a loss of heterozygosity at both markers. Sequencing of the MEN-1 gene revealed no germline mutations in either family, nor was a somatic mutation found in tumor DNA from one subject in family A. The integrity of the MEN-1 gene in this subject was further supported by demonstration of the presence of MEN-1 messenger ribonucleic acid, as assessed by RT-PCR. These data indicate that loss of heterozygosity in these affected family members appears independent of MEN-1 gene changes and suggest that a novel (tissue-specific?) tumor suppressor gene(s) linked to the PYGM marker and expressed in the pituitary is essential for regulation of somatotrope proliferation.
Heat of Adsorption of Butane on Multiwalled Carbon Nanotubes (2004)

We report the isosteric heats of adsorption, qst, for butane on multiwalled carbon nanotubes (MWNTs) over a range of surface loadings at temperatures below the normal boiling point. Butane is a nonspherical, nonpolar molecule that may exhibit different orientations in multilayer adsorption. The morphology of our MWNTs is such that only surface adsorption or capillary condensation can occur: no interstitial sites between nanotubes are available to butane. For these nanotubes, exterior surface adsorption is the principal mechanism measured by gravimetric analysis as the internal pores are only a small volume fraction of the total solid volume. The isosteric heat of adsorption varied with the surface coverage, θ, defined as the ratio of adsorbed butane to the MWNT butane monolayer capacity. The initial heat of adsorption was in the region ∼22−26 kJ/mol, which is approximately 1/3 lower than the corresponding value for various graphite−butane systems. At θ = 1, qst displays a minima (13.5−15.9 kJ/mol). The isosteric heat of adsorption approaches the butane heat of condensation for θ > 2.5, suggesting that the surface film is similar to a bulk phase. The isosteric heat of adsorption of butane on MWNTs can be related to the morphology of the MWNTs. The higher heats of adsorption at low coverages are likely related to the presence of surface defects. The minima in qst near the monolayer coverage relates to a high self-association of butane. At high loadings, the butane surface film is similar to a bulk phase.
BlackjackBench: Portable Hardware Characterization with Automated Results' Analysis (2013)

DARPA's AACE project aimed to develop Architecture Aware Compiler Environments. Such a compiler automatically characterizes the targeted hardware and optimizes the application codes accordingly. We present the BlackjackBench suite, a collection of portable micro-benchmarks that automate system characterization, plus statistical analysis techniques for interpreting the results. The BlackjackBench benchmarks discover the effective sizes and speeds of the hardware environment rather than the often unattainable peak values. We aim at hardware characteristics that can be observed by running executables generated by existing compilers from standard C codes. We characterize the memory hierarchy, including cache sharing and non-uniform memory access characteristics of the system, properties of the processing cores affecting the instruction execution speed and the length of the operating system scheduler time slot. We show how these features of modern multicores can be discovered programmatically. We also show how the features could potentially interfere with each other resulting in incorrect interpretation of the results, and how established classification and statistical analysis techniques can reduce experimental noise and aid automatic interpretation of results. We show how effective hardware metrics from our probes allow guided tuning of computational kernels that outperform an autotuning library further tuned by the hardware vendor.
Dielectric property and thermal stability of HfO2 on silicon (2002)

A stoichiometric, uniform, and amorphous hafnium oxide thin film is deposited by an atomic layer deposition process. The as-deposited hafnium oxide films showed superior electrical properties compared to zirconium oxides, including a dielectric constant of 23, a flatband voltage shift of +0.3 V, a hysteresis of 25 mV, an interfacial trap density of 1.8×1011 cm−2 eV−1, and a leakage current density several orders of magnitude lower than SiO2 at an equivalent oxide thickness of 9.3 Å, suitable for metal–oxide–semiconductor device applications. The thermal stability of hafnium oxide on silicon was determined to be better than that of zirconium oxide. Post-deposition annealing in oxygen and ammonia further improved the thermal stability of HfO2 to 1000 and 1100 °C, respectively.
Graphene oxide for electronic and photonic chips (2023)

&lt;p&gt;As a derivative of graphene, graphene oxide (GO) was initially developed by chemists to emulate some of the key properties of graphene, but it was soon recognized as a unique material in its own right, addressing an application space that is not accessible to chemical vapor deposition based materials. Over the past decade, GO has emerged as a new frontier material with tremendous advances in its material fabrication and quality control over its properties. These in turn have led to rapid progress in GO based photonics, electronics, and optoelectronics concepts and devices, evoking new science and paving the way for many technological breakthroughs with exceptional performance. Here, we review the unique fundamental characteristics of GO, its thin film fabrication methods, patterning techniques, and mechanisms for tuning its material properties. This latter capability in particular has enabled novel advanced functional photonic, electronic, and optoelectronic devices. Understanding these insights is essential for designing and tailoring GO properties for state-of-the-art applications including solar energy harvesting, energy storage, medical diagnosis, image displays, and optical communications. We conclude by discussing the open challenges and exciting opportunities of this field, together with future prospects for major technological advancements and breakthroughs.&lt;/p&gt;
Inversion Recovery Based Magnetization Transfer Mapping in the Human Myocardium In the presence of Incomplete Bound Pool Saturation at 3T (2023)

Quantitative imaging of magnetization transfer (MT) may enable non-contrast assessment of myocardial scar and fibrosis. However, its application at 3T has so far been limited. In this work we investigate an inversion recovery based method for joint quantification of T1 and MT maps. A numerical binary spin-bath model is used to account for incomplete bound pool saturation in the presence of limited preparation durations. In vivo images were obtained with high visual map quality for both T1 and MT quantification, and comparable, low CoV across the two parameters (T1: 5.5+-0.6% and MT: 5.8+-0.9%).
Fast Optical Circuit Switch Using Monolithically Integrated Silicon-Photonic Space Switch and Wavelength-Tuneable Filter (2018)

We demonstrate fast optical circuit switching from a monolithically integrated optical space switch and wavelength-tuneable filter on a silicon-photonic chip. Feasibility is confirmed by proof-of-concept experiments using 43-Gbps DQPSK signals. Switching time of 10 μs is attained.
Deterministic 3D self-assembly of Si through a rim-less and topology-preserving dewetting regime (2019)

International audience
System-in-a-package technology for 3D integration of radar modules (2008)

3D thin-film technology including substrate vias and integrated passives is used as a platform for heterogeneous integration of high frequency wireless systems and radar. The features of the technology are first described and next demonstrated with an integrated Doppler radar operating in the Ku band.
Une séquence radiométrique du Néolithique final à La Tène finale: le "Pilier stratigraphique" de Han-sur-Lesse (prov. de Namur, Belgique) (2012)

info:eu-repo/semantics/published
High-performance on-road vehicle detection in monocular images (2013)

This paper addresses the problem of monocular vehicle detection for forward collision warning. We present a system that is able to process large images with high speed and delivers high detection rates at only one false alarm every 100 frames.
3D Particle Simulation of Hot Dense Plasma. (1991)

is a 3D particle code SCOPE which has been developed to simulate a large scale two component strongly coupled plasma.
Recertification (1999)

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CLXXXVIII.—A synthesis of pyrylium salts of anthocyanidin type (1922)

D. D. Pratt and R. Robinson, J. Chem. Soc., Trans., 1922, 121, 1577 DOI: 10.1039/CT9222101577
Shaft currents in electric machines (1924)

W. F. Dawson: I can endorse one point which Mr. Alger made, namely that shaft currents are often associated with high saturation in the stationary armature cores of synchronous generators.
Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors (2016)

Our novel approach to quantifying both inhibitory and co-agonist effects of pentobarbital provides a basis for future structure-function analyses of GABAA receptor mutations in putative pentobarbital binding sites.
Foaming in anaerobic digesters caused by (1998)

Three large wastewater treatment plants in the greater Stockholm area have experienced serious anaerobic digester foaming. Microscopic studies of the sludge from the foam phase showed a network of the filamentous organism Microthrix parvicella . The morphology of the long, coiled filament appeared to be affected by the anaerobic conditions where it became broken up into to shorter and thicker filaments. The operating strategy to prevent foam in the anaerobic digesters at these plants is to control the growth of M. parvicella in the activated sludge tanks by increasing the sludge load. Top installed stirrers and the addition of poly-aluminium salt have also been used to prevent foam formation.
Pressure mapping system for physiological measurements (2006)

Abstract: Pressure mapping provides knowledge about interface pressure between a person and the surface person is laying or sitting on. In medical applications the surface is commonly a bed or a wheelchair. The distribution of pressure applied to the skin by a supporting surface can be measured with a pressure mapping system. Depending on the magnitude and duration of the pressure, it can cause pain and tissue injuries, such as pressure ulcers to the person. By means of pressure mapping technology, it is possible to detect the areas where the pressure is concentrated and thus prevent the development of pressure ulcer. However, the properties of the commercial pressure mapping systems are usually inadequate for physiological measurements. In this study, properties of a commercial Xsensor pressure mapping system were studied. Measurements with test persons as well as measurements with a constant measurement load were carried out. Repeatability, sensitivity, temperature sensitivity and hysteresis of the pressure sensor were determined. Only the hysteresis was noticed to be poor while the other properties were satisfactory.
FASTBUS readout system for the CDF DAQ upgrade (1994)

The Data Acquisition System (DAQ) at the Collider Detector at Fermilab is currently being upgraded to handle a minimum of 100 events/sec for an aggregate bandwidth which is at least 25 Mbytes/sec. The DAQ System is based on a commercial switching network which has interfaces to VME bus. The modules that read out the front end crates (FASTBUS and RABBIT) have to deliver the data to the VME bus based host adapters of the switch. This paper describes a read out system that has the required bandwidth while keeping the experiment deadtime due to the read out to a minimum.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Anti-gingivitis effects of a novel 0.454% stabilized stannous fluoride dentifrice relative to a positive control. (2012)

A total of 196 subjects completed the trial and were evaluable. At Month 2, both test dentifrices produced statistically significant reductions in number of bleeding sites, GBI, and MGI on average relative to pre-treatment (P< 0.0001). The Month 2 adjusted mean improvement from baseline for the stannous fluoride dentifrice group was 62% greater for number of bleeding sites, 60% greater for GBI, and 45% greater for MGI versus the triclosan/copolymer positive control group; groups differed significantly (P<0.0001) for each gingivitis measure at Month 2. Both dentifrices were well-tolerated.
Faculty Opinions recommendation of Two functionally different vacuoles for static and dynamic purposes in one plant mesophyll leaf cell. (2004)

It is a common belief that plant mesophyll cells are occupied up to 95% by a single multipurpose vacuole. The common ice plant, Mesembryanthemum crystallinum L., however, requires two contrasting functions of the vacuole under salt stress. Large amounts of NaCl have to be sequestered permanently for osmotic purpose and for protecting the cytoplasm from NaCl toxicity. A dynamic exchange with the cytoplasm is required because photosynthesis proceeds under these conditions via the metabolic cycle of crassulacean acid metabolism (CAM). Nocturnally acquired CO2 must be kept as malate in the vacuole and re-mobilized in the daytime. Here, we show that two large independent types of vacuoles with different transport properties meet the requirements for the contrasting functions within the same cell. PMID: 14690512
Molecular cloning, expression and exon/intron organization of the bovine -galactoside 2,6-sialyltransferase gene (1999)

In this study, we report the first isolation and characterization of a bovine sialyltransferase gene. Bovine cDNAs prepared from different tissues contain an open-reading frame encoding a 405 amino acid sequence showing 83%, 75%, and 60% identity with human, murine, and chicken ST6Gal I (beta-galactoside alpha2,6-sialyltransferase) sequences, respectively. When transfected into COS-7 cells, a recombinant enzyme was obtained which catalyzed the in vitro alpha2, 6-sialylation of LacNAc (NeuAcalpha2-6Galbeta1-4GlcNAc) and LacdiNAc (NeuAcalpha2-6GalNAcbeta1-4GlcNAc) acceptor substrates. The K (m) values were 2.8 and 6.9 mM, respectively. Different relative efficiencies (Vmax/Km) for the two precursors (36 for LacNAc and 4.3 for LacdiNAc) were observed. Bovine ST6Gal I gene consists of four 5'-untranslated exons E(-2) to E(1), and five coding exons from E(2) to E(6). This later carries a 3'-untranslated region of 2. 7 kb. Gene sequence spans at least 80 kb of genomic DNA. Two processed pseudogenes have been identified. They are 94.3 and 95.6% similar to the bovine cDNA, respectively. Three families of mRNA isoforms were isolated. They differed by their 5'-untranslated regions and could be generated by three tissue-specific promoters. Family 1 is made up of exons E(-2) and E(1) to E(6), family 2 of exons E(-1) to E(6), and family 3 of exons E(1) to E(6). Tissular distribution of transcript families appears noticeably different than those described in human and rat.
Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease (2017)

Neem leaf extract, containing polyphenols that adhere to oral surfaces, have the potential to provide long-lasting antibacterial as well as synergic antioxidant activities when in complex with bacteria, red blood cells and lisozyme. Thus, it might be especially effective in periodontal diseases.
<title>Hologram counterfeiting: problems and solutions</title> (1990)

A brief survey of simple hologram counterfeiting techniques
and appropriate countermeasures is given and specific cases of
successful and unsuccessful counterfeiting attempts are discussed.
An inverse method for determining parameters for folded structures (1996)

General analytic solutions are presented here to an equation relating two angles describing fault shape, and two angles describing fold shape. The analytic solutions provide any of the four angles when the other three are given.
Widely tunable erbium-doped fiber ring laser for fiber optics tests and measurements in the C and L bands (2000)

A widely tunable multilongitudinal-mode erbium-doped fiber ring laser covering both C and L bands (1506.4-1618.6 nm) is reported. This source presents an excellent wavelength and power repeatability and high optical signal-to-ASE-noise ratio.
The mannose 6‐phosphate/insulin‐like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells (2008)

The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) mediates biosynthetic sorting and endocytosis of various factors that impinge on the proliferation, migration and invasiveness of tumour cells. The gene encoding M6P/IGF2R is frequently lost or mutated in a wide range of malignant tumours including squamous cell carcinomas. We have previously shown that M6P/IGF2R-deficient SCC-VII murine squamous cell carcinoma cells secrete large amounts of pro-invasive lysosomal proteinases. Furthermore, the formation of mature lysosomes is impaired in SCC-VII cells. To assess the link between M6P/IGF2R status and tumour invasion, we have now generated SCC-VII lines stably transfected with human M6P/IGF2R cDNA. Reconstitution of functional M6P/IGF2R expression in SCC-VII cells strongly improves the intracellular retention of lysosomal proteinases and restores the formation of mature lysosomes. In addition, the presence of heterologous M6P/IGF2R compromises the growth of SCC-VII cells both in vitro and in vivo. Remarkably, M6P/IGF2R expression also reduces the invasive capacity of SCC-VII cells in response to various chemoattractants. These results indicate that the M6P/IGF2R status influences the metastatic propensity of squamous cell carcinomas.
Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. (1997)

The results suggest the following: (1) that the deletions of p15 and/or p16 genes play a key role in the progression of ATL; and (2) that these deletions are reliable prognostic factors that predict shortened survival times.
Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach (2023)

Bronchial asthma is the most frequent inflammatory non-communicable condition affecting the airways worldwide. It is commonly associated with concomitant conditions, which substantially contribute to its burden, whether they involve the lung or other districts. The present review aims at providing an overview of the recent acquisitions in terms of asthma concomitant systemic conditions, besides the commonly known respiratory comorbidities. The most recent research has highlighted a number of pathobiological interactions between asthma and other organs in the view of a shared immunological background underling different diseases. A bi-univocal relationship between asthma and common conditions, including cardiovascular, metabolic or neurodegenerative diseases, as well as rare disorders such as sickle cell disease, α1-Antitrypsin deficiency and immunologic conditions with hyper-eosinophilia, should be considered and explored, in terms of diagnostic work-up and long-term assessment of asthma patients. The relevance of that acquisition is of utmost importance in the management of asthma patients and paves the way to a new approach in the light of a personalized medicine perspective, besides targeted therapies.