gebhart/patrepeval huggingface dataset:
Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies (1995)

Antibodies to several epitopes of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120-gp41) can synergize in inhibiting HIV-1 infection. In the present study we tested the ability of a monoclonal antibody (MAb), 5A8, which interacts with CD4 domain 2, and other CD4-specific MAbs to synergize with antibodies against gp120. We have previously found that 5A8 inhibits HIV-1 entry without interfering with gp120 binding to CD4, presumably by affecting a postbinding membrane fusion event. Because antibodies to the gp120 V3 loop also affect post-CD4-gp120-binding events, 5A8 was first tested in combination with anti-V3 loop antibodies for possible synergy. The anti-V3 loop antibodies 0.5 beta, NEA-9205, and 110.5 acted synergistically with 5A8 in inhibiting syncytium formation between gp120-gp41- and CD4-expressing cells. A human MAb to an epitope of gp120 involved in CD4 binding, IAM 120-1B1, and another anti-CD4 binding site antibody, PC39.13, also exerted synergistic effects in combination with 5A8. Similarly, an antibody against the gp120 binding site on CD4, 6H10, acted synergistically with an anti-V3 loop antibody, NEA-9205. However, a control anti-CD4 antibody, OKT4, which does not significantly inhibit syncytium formation alone, produced only an additive effect when combined with NEA-9205. Serum from HIV-1-infected individuals, which presumably contains antibodies to the V3 loop and the CD4 binding site, exhibited a strong synergistic effect with 5A8 in inhibiting infection by a patient HIV-1 isolate (0104B) and in blocking syncytium formation. These results indicate that therapeutics based on antibodies affecting both non-gp120 binding and gp120 binding epitopes of the target receptor molecule, CD4, could be efficient in patients who already contain anti-gp120 antibodies and could also be used to enhance passive immunization against HIV-1 in combination with anti-gp120 antibodies.
Energetics of Leukocyte Integrin Activation (1995)

Cell adhesion mediated by leukocyte integrin CR3 (CD11b/CD18, alpha m beta 2) may be rapidly modulated without changes in receptor number, and transient changes in adhesivity are thought to be driven by reversible alteration of the affinity of CR3 for ligand. Here we measure the binding affinity of CR3 using purified active and inactive receptor and the ligand, C3bi, coupled to alkaline phosphatase. Immobilized, active CR3 bound saturably and with high affinity (12.5 +/- 4.7 nM). In contrast, inactive CR3 exhibited no measurable binding. High affinity binding could be restored by the addition of the activating anti-CR3 monoclonal antibody KIM-127 to inactive CR3. Since the affinity of KIM-127 for active and inactive receptor was identical, it cannot contribute the energy to convert a low affinity receptor into a high affinity receptor. Rather, KIM-127 appears to facilitate binding of C3bi by lowering the activation energy for the shift from an inactive to an active state. These results suggest that CR3-mediated binding and detachment of cells is not driven by a reversible change in affinity but by two mechanistically distinct processes, an energetically neutral activation step for binding and an energy-dependent step that reverses binding of ligand.
Extended generalized impedance control for redundant manipulators (2004)

An impedance control method for redundant manipulators called an extended generalized impedance control is developed. It is based on an extended task space formulation and generalized impedance control. With generalized impedance control, the manipulator's end-effector position and force tracking abilities can be balanced by properly adjusting impedance parameters. Null space motion is controlled by tracking a minimal parameterization of null space velocity. Redundancy is then exploited by specifying a desired null space velocity trajectory that optimizes a performance index. The control algorithm is implemented as part of OSCAR (Operational Software Components for Advanced Robotics), keeping with the generality concept. Therefore, it can be easily deployed with any serial manipulator. The effectiveness of the proposed controller is illustrated by computer simulations of a complex 10-DOF spatial manipulator performing a cutting task.
Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015 (2020)

Adults hospitalised with pCAP in the age cohort of 50-64 years contribute significantly to the burden of illness, suggesting that an age-based recommendation for adults aged ≥50 years should be considered in order to optimise the impact of pneumococcal vaccination programmes in Canada.
ChemInform Abstract: A Green N‐Detosylation of Indoles and Related Heterocycles Using Phase Transfer Catalysis. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Iterative Design Techniques for All-Pole Dual-Bandpass Filters (2007)

Two iterative techniques to design all-pole dual-bandpass filters are presented. The oversized aspect of the problem is highlighted and the system is solved by relaxing a parameter, which ensures the convergence. The proposed methods are based on the Remez algorithm and the match points technique. Both methods are applied to design filters by relaxing either a bandpass edge frequency or a ripple level. Also, two examples are presented and demonstrate the speed and accuracy of the proposed techniques.
Identification of the Current—Voltage Characteristic of Photovoltaic Arrays (2016)

International audience
Predicting the suitability for scene matching using SVM (2008)

Interrelation and constraint between multi-measure parameters of reference image and suitable matching area have not been considered in most of methods for selecting matching area. In order to overcome this drawback, we present a novel method of predicting the suitability using support vector machine (SVM). Firstly, gray-based and edge-based measure parameters are selected. Then the sample images data set are trained with radial basis kernel function after normalization of input vectors composed of measure parameters. Finally, we separate suitable matching area class and unsuitable matching area class using decision function. Thus we can predict the suitability and guide scene matching process. The experimental results show that this method holds the capability of flexibility and jamming resistance as well as proper guide to selection of suitable matching area from complex reference image.
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features (2021)

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown.In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluorescence (mIF).Our results demonstrate that anti-tumor immunity evolved as a continuum from lung preneoplasia, to preinvasive ADC, minimally-invasive ADC and frankly invasive lung ADC with a gradually less effective and more intensively regulated immune response including down-regulation of immuneactivation pathways, up-regulation of immunosuppressive pathways, lower infiltration of cytotoxic T cells (CTLs) and anti-tumor helper T cells (Th), higher infiltration of regulatory T cells (Tregs), decreased T cell clonality, and lower frequencies of top T cell clones in laterstages.Driver mutations, chromosomal copy number aberrations (CNAs) and aberrant DNA methylation may collectively impinge host immune responses and facilitate immune evasion, promoting the outgrowth of fit subclones in preneoplasia into dominant clones in invasive ADC.
System-Level Integrated Circuit (SLIC) Technology Development for Phased Array Antenna Applications (1997)

This report documents the efforts and progress in developing a 'system-level' integrated circuit, or SLIC, for application in advanced phased array antenna systems. The SLIC combines radio-frequency (RF) microelectronics, digital and analog support circuitry, and photonic interfaces into a single micro-hybrid assembly. Together, these technologies provide not only the amplitude and phase control necessary for electronic beam steering in the phased array, but also add thermally-compensated automatic gain control, health and status feedback, bias regulation, and reduced interconnect complexity. All circuitry is integrated into a compact, multilayer structure configured for use as a two-by-four element phased array module, operating at 20 Gigahertz, using a Microwave High-Density Interconnect (MHDI) process. The resultant hardware is constructed without conventional wirebonds, maintains tight inter-element spacing, and leads toward low-cost mass production. The measured performances and development issues associated with both the two-by-four element module and the constituent elements are presented. Additionally, a section of the report describes alternative architectures and applications supported by the SLIC electronics. Test results show excellent yield and performance of RF circuitry and full automatic gain control for multiple, independent channels. Digital control function, while suffering from lower manufacturing yield, also proved successful.
The handbook of plant mutation screening: mining of natural and induced alleles. (2010)

INDUCED MUTATIONS Physically induced mutagenesis: Ion beam mutagenesis (Magori, Tanaka, Kawaguchi) Ds transposon mutant lines for saturation mutagenesis of the Arabidopsis genome (Kuromori, Hirayama) Use of mutants from T-DNA insertion populations generated by high-throughput screening (Stracke, Huep, Weisshaar) Making mutations is an active process: Examining DNA polymerase errors (Eckert, Gestl) Tnt1 induced mutations in Medicago: Characterisation and Applications (Ratet, Cosson, Wen, Tadege, Mysore) MUTATION DISCOVERY Sequencing by synthesis: Mutation detection with the Illumina Genome Analyzer (Lakdawalla, Schroth) Chemical methods for mutation detection: The chemical cleavage of mismatch (CCM) method (Tabone, Sallmann, Cotton) Mutation detection in plants by enzymatic mismatch cleavage (Till) Mutation scanning and genotyping in plants by high resolution DNA melting (McKinney, Nay, Koeyer, Reed, Wall, Palais, Jarret, Wittwer) In silico methods: Mutation detection software for Sanger sequencing, fragment and genome analysis (LeVan, Liu, Shouyong) HIGH-THROUGHPUT SCREENING METHODS Use of TILLING for reverse and forward genetics of rice (Terauchi) Sequencing-based high-throughput mutation screening using KeyPointTM technology (Rigola, van Eijk) APPLICATIONS IN PLANT BREEDING Natural and induced mutants of barley: SNPs in genes important for breeding (Thomas, Waugh, Forster, Franckowiak) Association mapping for the exploration of genetic diversity and identification of useful loci for plant breeding (Belo, Luck) Using mutations in corn breeding programs (Scott, Bodnar) Gene targeting as a precise tool for plant mutagenesis (Zobell, Reiss) EMERGING TECHNOLOGIES Direct single-molecule DNA sequencing:Helicos BioSciences technology and applications (Jenkins, Kahvejian) Mutation detection by genome sequencing with universal probes (Linnarsson) Emerging Technologies: Detection of mutations with the Pinpoint Sequencer (Ju) Emerging Technologies: Nanopore Sequencing for Mutation Detection (Rollings, Li) Glossary
Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma. (1999)

Activating mutations of the RET proto-oncogene cause hereditary medullary thyroid carcinoma. To examine whether selective inactivation of mutant RET could prevent transformation, a hammerhead ribozyme was designed to cleave RET mRNA containing a transforming mutation of codon 634 TGC --> TAC (Cys634Tyr). In vitro RNA cleavage assay demonstrated that the ribozyme selectively cleaved RET RNA with a Cys634Tyr but not Cys634Arg or the normal sequence. Expression of ribozyme in NIH/3T3 cells prevented RET-mediated colony formation in soft agar. This inhibition required catalytically active ribozyme and was specific for the TAC mutation. Therefore, ribozymes designed to selectively target mutant RET RNA may provide an effective therapeutic in the treatment of this syndrome.
Self-matched high-voltage rectangular wave pulse generator (1985)

This article describes the self-matched pulse generator, an efficient high-voltage generator which produces a rectangular wave pulse. It generates rectangular wave pulses with a duration from a few nanoseconds to a few microseconds. The waveform of the generated pulses is maintained regardless of the resistivity of the load. The principles of its operation and applications are described.
A segmented ring, cylindrical ion trap source for time-of-flight mass spectrometry (1996)

An ion trap source has been designed for use with time-of-flight (TOF) mass analysis. Two thin diaphragms make up a segmented ring electrode; the end cap electrodes are planar wire mesh. The potential field produced by the rf voltage applied between the ring and end cap electrodes resembles that of the cylindrical ion trap. The trapped ion population for ions created by electron impact exhibits linear growth against a first-order loss that has a time constant of about 50 µs; no ion loss occurs when the electron beam is off. The observed value of q z at low-mass cutoff for rf ion storage is -0.84. Pulsed extraction of all ions is accomplished by switching the trap electrodes from rf to voltages required to provide a linear dc extraction field. The TOF flight path includes a wide energy range reflectron. Better than unit mass resolution is achieved through m/z 500 without collisional ion cooling. With an extraction rate of 1 kHz and a recording rate of 4 spectra per second, a linear working curve is obtained between 36 pg and 18 ng of chlorobenzene delivered chromatographically. The system has demonstrated the potential to achieve a very high sample utilization efficiency at high spectral generation rates.
Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery (2018)

Five lymphoblastoid cell lines derived from mitochondrial disease patients harboring point mutations in mtND1, mtND4, or mtATP6 were characterized in two high throughput assays assessing mitochondrial function. In a pilot "clinical trial in a dish" experiment, the efficacy of idebenone-an approved therapy for mitochondrial disease-on the lymphoblastoid cell lines was tested. Idebenone increased the basal respiration of all lymphoblastoid cell lines except those harboring the 8993T>G point mutation in mtATP6. Our results posit lymphoblastoid cell lines as a strong model for mitochondrial disease research with small molecules and have implications for the clinical efficacy of idebenone.
Removal of Nano-sized Particles Using Carbon Dioxide (CO2) Gas Cluster Cleaning without Pattern Damage (2015)

As pattern size of semiconductor device becomes less than 20 nm, the removal of particles smaller than 10 nm without pattern damages requires new physical dry cleaning technology. CO2 gas cluster cleaning is an alternative dry cleaning process to meet these cleaning requirements. To demonstrate gas cluster cleaning performance, particle removal efficiency (PRE) and gate structure pattern damages were evaluated. When pressurized and low temperature CO2 gas was passed through a convergence–divergence (C–D) nozzle, high energy CO2 gas clusters were generated at high speed in a vacuum atmosphere. The cleaning force of the CO2 gas cluster is related to the flow rate of the CO2 gas. The optimum CO2 gas flow rate for the particle removal without pattern damage was found to be 6 L/min (LPM). Removal efficiency for 50 nm silica particles was greater than 90%, and no pattern damage was observed on 60 nm poly-Si and a-Si gate line patterns. It was confirmed that the CO2 gas cluster cleaning force could be controlled by the CO2 gas flow rate supplied to nozzle.
Differential Expression of Profibrotic and Growth Factors in Chronic Allograft Nephropathy (2006)

Microarrays might be an important tool to uncover the mechanisms of multifactorial diseases, such as CAN.
In(iii)-dictated formation of double Cs2AgxNa1−xFeyIn1−yCl6 perovskites (2023)

Doping with In( iii ) induces the formation of stable and phase-pure Cs 2 Ag x Na 1− x Fe y In 1− y Cl 6 perovskites with bandgaps close to 2 eV.
Optimal Mixture Designs for Heavy Metal Encapsulation in Municipal Solid Waste Incineration Fly Ash (2020)

Mixing municipal solid waste incineration fly ash (MSWIFA) with industrial by-products such as ground granulated blast furnace slag (GGBFS) and ladle furnace slag (LFS) can lead to a hardened system which can encapsulate the heavy metals present in the MSWIFA. The objective of this study is to find optimal mixture designs to effectively encapsulate these heavy metals. The nature of the hydrates and the strength of the mixtures are studied to develop a sustainable and practical construction material incorporating MSWIFA. Heavy metals including Cr, Cu, Zn and Cd are safely encapsulated in several developed mixtures with leachate concentration below EPA drinking water limit. The encapsulation behavior is complex and depends on metal type, age of testing, and hydration products. In general, mixtures containing LFS have more aluminate hydrates, and show greater encapsulation capacity for most heavy metals. However, they also generally show significant Sb leaching. Mixtures which show satisfactory encapsulation for all ions and adequate strength development are identified. Three ideal mixtures, including one containing zero cement, are identified which satisfy both leaching and strength requirements.
Thin film BAW filters for wide bandwidth and high performance applications (2004)

Thin film bulk acoustic wave (BAW) resonator based filter technology offers several options for the implementation of wide bandwidth and high performance filters for emerging wireless applications. By employing wafer scale manufacturing using IC processing techniques BAW shows potential for low cost manufacturing. This paper will give examples of high performance filters including design results using ladder and coupled resonator filters.
Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/Obese Adults (2008)

Obesity is associated with vascular endothelial dysfunction, as indicated by impaired endothelium-dependent dilation. Presently there is no direct evidence that energy intake-restricted weight loss alone improves conduit or resistance artery endothelium-dependent dilation, the mechanisms involved, or whether improvements differ with patient age. A total of 40 overweight or obese (body mass index: >or=25<40 kg/m(2)) nondiabetic men and women aged 21 to 69 years completed 12 weeks of reduced energy intake (n=26; 15 male) or attention control (n=14; 9 male) and 4 weeks of weight maintenance (randomized trial). Energy intake restriction reduced estimated total energy intake (33%), body weight (10.5%), total and abdominal body fat, plasma leptin, oxidized low-density lipoprotein, and improved several metabolic risk factors. Brachial artery flow-mediated dilation was increased by 30% (6.0+/-0.7% versus 7.9+/-0.7%Delta; P=0.01; n=17). Peak forearm blood flow during intrabrachial artery infusion of acetylcholine was increased by 26% (16.8+/-1.4 versus 21.1+/-1.9 mL/100 mL per minute; P<0.05; n=15); this was inversely related to the reduction in the abdominal visceral:subcutaneous fat ratio (r=-0.46; P<0.05) and was abolished by inhibition of NO synthesis with N(G)-monomethyl-L-arginine. Improvements in endothelium-dependent dilation were not related to age: mean increases in subjects >50 years of age were similar to or greater than those <50 years of age. Energy intake-restricted weight loss alone is an effective intervention for improving peripheral conduit and resistance artery endothelial function in young and older overweight/obese adults. The improvements in resistance artery function are mediated by an increase in NO bioavailability and are related to reductions in abdominal visceral fat.
SIMPLIFIED TECHNIQUE OF ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS1 (2001)

Simplified technique without VVB is appropriate for successfully achieving OLT in pigs.
<title>Conformal dome aberration correction with counter-rotating phase plates</title> (1999)

ABSTRACT Domes have been designed that conform to the aerodynamic requirements of airborne systems, as well as the opticalrequirements. Such domes have large amounts of aberrations - lOs to lOOs of waves. Typical systems also have gimbals thatpoint the optical line of sight through different parts of the domes. Aberrations vary significantly with pointing angle andtherefore require dynamic correction. This paper describes the performance of a new class of optical systems that employcounter-rotating phase plates to correct conformal dome aberrations. The correctors are described by Zernike circularpolynomials. Since the shear is rotational, only aberrations with non-rotational symmetry can be created, like coma orastigmatism. A theoretical development shows the relationship between the corrector surface shapes and the aberrationscreated. Code V was used to model the correction capabilities of the angular shear corrector plates.Keywords: conformal optics, dome, window, aberration, correction, phase plate
Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation (2019)

Development of simple and fully characterized immunomodulatory molecules is an active area of research to enhance current immunotherapies. Monophosphoryl lipid A (MPL), a nontoxic lipidic derivative from bacteria, is the first and currently only adjuvant approved in humans. However, its capacity to induce a potent response against weak immunogenic tumoral-associated antigens remains limited. Herein, a new generation of lipidic immunomodulators to conduct a structure-activity relationship study to determine the minimal structural elements conferring immunomodulatory properties is introduced. Two lead molecules characterized by a short succinyl linker between two oleyl chains and a polar headgroup consisting of either naturally occurring tobramycin (DOST) or kanamycin (DOSK) are identified. These two lipoaminoglycosides self-assemble in very small vesicles. In a wide variety of cells including 3D human cell culture, DOST and DOSK induce the upregulation of proinflammatory cytokines and interferon-inducible proteins in a dose and time-dependent manner via a caveolae-dependent proinflammatory mechanism and phosphatidylinositol phospholipase C activation. Furthermore, after intratumoral administration, these lipoaminoglycosides induce an efficient immune response leading to significant antitumor activity in a mouse breast cancer model. Altogether, these findings indicate that DOST and DOSK are two groundbreaking synthetic lipid immunostimulators that can be used as adjuvants to enhance current immunotherapeutic treatments.