gebhart/patrepeval huggingface dataset:
Farm exposurein uteromay protect against asthma, hay fever and eczema (2008)

The aim of the present study was to assess which factors contribute to the lower prevalence of allergic diseases in farmers' children, and the importance of timing of exposure. In a cross-sectional questionnaire survey, asthma symptoms, hay fever and eczema were assessed, as well as current, early and prenatal farm-related exposures in 1,333 farmers' children and 566 reference children aged 5-17 yrs. Farmers' children had a lower incidence of asthma symptoms and eczema. Current and maternal exposure during pregnancy to animals and/or grain and hay reduced the risk of asthma symptoms, hay fever and eczema. The exposure-response association for maternal exposure was nonlinear for most outcomes. After mutual adjustment, the effects of prenatal exposure remained unchanged whereas current exposure remained protective only for asthma medication, asthma ever and hay fever. Exposure during the first 2 yrs was not associated with symptoms, after controlling for prenatal exposure. A combination of prenatal and current exposure was most strongly associated with wheeze (odds ratio (OR) 0.48, 95% confidence interval (CI) 0.28-0.80), asthma medication (OR 0.50, 95% CI 0.30-0.82), asthma ever (OR 0.50, 95% CI 0.33-0.76), hay fever (OR 0.47, 95% CI 0.30-0.73) and eczema (OR 0.46, 95% CI 0.30-0.70). Prenatal exposure may contribute to the low prevalence of asthma, hay fever and eczema in farmers' children, but continued exposure may be required to maintain optimal protection.
Color cast detection for surveillance video using additive and subtractive color system (2015)

To tackle color cast detection challenge, a new approach is proposed in this paper to detect color cast and estimate the extent of color cast using additive and subtractive color system. First, the proposed approach calculates bright and dark information and extreme intensity ratio, and then determines the type of bright and dark information according to extreme intensity ratio. Finally, the proposed approach determines color system type and cast variation channel, and estimates the extent of color cast using extreme intensity ratio and difference intensity. Experimental results show that the proposed approach is reliable and effective, as well as consistent to human's subjective evaluation.
Magnetic resonance imaging and histopathological characterization of prostate tumors in TRAMP mice as model for pre‐clinical trials (2006)

Prostate cancer in TRAMP mice is multifocal and heterogeneous: a non-invasive methodology such as MRI facilitates the rational design of translational pre-clinical trials in this widely used animal model.
Differential Regulation of Soybean Seed Storage Protein Gene Promoter-GUS Fusions by Exogenously Applied Methionine in Transgenic <italic>Arabidopsis thaliana</italic> (1994)

Expression of the gene encoding the β subunit of β-conglycinin, the 7S seed storage protein of soybean (Glycine max [L.] Merr.), has been shown to be down-regulated by exogenously applied L-methionine in in vitro soybean cotyledon cultures, whereas expression of the gene encoding the a′ subunit is not affected. We constructed transgenic Arabidopsis thaliana(L.) Heynh. carrying the β-glucuronidase (GUS) reporter gene under the control of the promoter regions from either the a′ or β subunit gene. An in vitro culture system of immature siliques of A. thaliana was developed for exogenous application of L-methionine to immature seeds. Expression of the fi subunit gene promoter-GUS fusion was down-regulated by the application of L-methionine, and this response was reversible. As an alternative way to apply L-methionine, A. thaliana plants were grown on rockwool and irrigated with L-methionine-supplemented medium. GUS activity driven by the β subunit gene promoter was repressed by L-methionine, and the degree of repression depended on the concentration of L-methionine in the medium. On the other hand, the a′ subunit gene promoter-GUS fusion did not show such a response. These results indicate that A. thaliana has a system to differentially regulate the expression of the β-conglycinin genes by L-methionine at the level of transcription. This work establishes a system to genetically analyze plants′ responses to nutritional stimuli.
Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling (2018)

Myocardial infarctions (MIs) cause the loss of myocytes due to lack of sufficient oxygenation and latent revascularization. Although the administration of histone deacetylase (HDAC) inhibitors reduces the size of infarctions and improves cardiac physiology in small-animal models of MI injury, the cellular targets of the HDACs, which the drugs inhibit, are largely unspecified. Here, we show that WNT-inducible secreted protein-1 (Wisp-1), a matricellular protein that promotes angiogenesis in cancers as well as cell survival in isolated cardiac myocytes and neurons, is a target of HDACs. Further, Wisp-1 transcription is regulated by HDACs and can be modified by the HDAC inhibitor, suberanilohydroxamic acid (SAHA/vorinostat), after MI injury. We observe that, at 7 days after MI, Wisp-1 is elevated 3-fold greater in the border zone of infarction in mice that experience an MI injury and are injected daily with SAHA, relative to MI alone. Additionally, human coronary artery endothelial cells (HCAECs) produce WISP-1 and are responsive to autocrine WISP-1-mediated signaling, which functionally promotes their proangiogenic behavior. Altering endogenous expression of WISP-1 in HCAECs directly impacts their network density in vitro. Therapeutic interventions after a heart attack define the extent of infarct injury, cell survival, and overall prognosis. Our studies shown here identify a potentially novel cardiac angiokine, Wisp-1, that may contribute to beneficial post-MI treatment modalities.
Un Test Non-paramétrique d'Homogénéité Séquentiel (2015)

Given samples from two distributions, a nonparametric two-sample testaims at determining whether the two distributions are equal or not,based on a test statistic. This statistic may be computed on the wholedataset, or may be computed on a subset of the dataset by a functiontrained on its complement. We propose a third tier, consisting offunctions exploiting a sequential framework to learn the differenceswhile incrementally processing the data. Sequential processingnaturally allows optional stopping, which makes our test the firsttruly sequential nonparametric two-sample test.We show that any sequential predictor can be turned into a sequentialtwo-sample test for which a valid $p$-value can be computed, yieldingcontrolled type I error. We also show that pointwise universalpredictors yield consistent tests, which can be built with anonparametric regressor based on $k$-nearest neighbors in particular.We also show that mixtures and switch distributions can be used toincrease power, while keeping consistency.
Activation of Cardiac Tissue by Extracellular Electrical Shocks (1998)

This study investigated the activation of cardiac tissue by "secondary sources," which are localized changes of the transmembrane potential (Vm) during the application of strong extracellular electrical shocks far from the shock electrodes, in cultures of neonatal rat myocytes. Cell monolayers with small intercellular clefts (length, 45 to 270 microm; width, 20 to 70 microm [mean+/-SD, 54+/-13 microm]; n = 46) were produced using a technique of directed cell growth. Changes in Vm relative to the action potential amplitude (deltaVm/APA) were measured using a fluorescent voltage-sensitive dye and a 10 x 10 photodiode array. Shocks with voltage gradients of 4 to 18 V/cm were applied across the clefts during either the action potential (AP) plateau or diastole. During the AP plateau, shocks induced secondary sources in the form of localized hyperpolarizations and depolarizations in the regions immediately adjacent to opposite sides of the clefts. The strength of the secondary sources, defined as the difference of deltaVm/APA across a cleft, increased with increasing cleft length or increasing electrical field gradient. For shocks with a gradient of 8.5 V/cm, the estimated critical cleft length necessary to reach a Vm level corresponding to the diastolic threshold of excitation was 171+/-7 microm. Accordingly, shocks with average strength of 8.2 V/cm applied during diastole produced secondary sources that directly excited cells adjacent to the clefts when the cleft length was 196+/-53 microm (n = 14) and that failed when the cleft length was 84+/-23 microm (n = 9, P<.001). The area of earliest excitation in such cases coincided with the area of maximal depolarization induced during the plateau phase. These data suggest that small inexcitable obstacles may contribute to the Vm changes during the application of strong extracellular electrical shocks in vivo.
Addressing dresses (2015)

Wearable technology projects afford the opportunity to work within interdisciplinary teams to create truly innovative solutions. Sometimes it is difficult for teams of designers and engineers to work together because of process differences and communication issues. Here we present a case study that describes how one team developed a system to overcome these obstacles and propose viewing interdisciplinary collaboration tools as boundary objects. The system described here allows designers to work with programmers to create full color light effects in real time, through a calibration process and interface that allows designers an easy entry into discussions about the placement of electronics in an LED-embedded garments.
Stabilization of the R Allosteric Structure of Escherichia coli Aspartate Transcarbamoylase by Disulfide Bond Formation (2002)

Here we report the first use of disulfide bond formation to stabilize the R allosteric structure of Escherichia coli aspartate transcarbamoylase. In the R allosteric state, residues in the 240s loop from two catalytic chains of different subunits are close together, whereas in the T allosteric state they are far apart. By substitution of Ala-241 in the 240s loop of the catalytic chain with cysteine, a disulfide bond was formed between two catalytic chains of different subunits. The cross-linked enzyme did not exhibit cooperativity for aspartate. The maximal velocity was increased, and the concentration of aspartate required to obtain one-half the maximal velocity, [Asp](0.5), was reduced substantially. Furthermore, the allosteric effectors ATP and CTP did not alter the activity of the cross-linked enzyme. When the disulfide bonds were reduced by the addition of 1,4-dithio-dl-threitol the resulting enzyme had kinetic parameters very similar to those observed for the wild-type enzyme and regained the ability to be activated by ATP and inhibited by CTP. Small-angle x-ray scattering was used to verify that the cross-linked enzyme was structurally locked in the R state and that this enzyme after reduction with 1,4-dithio-dl-threitol could undergo an allosteric transition similar to that of the wild-type enzyme. The complete abolition of homotropic and heterotropic regulation from stabilizing the 240s loop in its closed position in the R state, which forms the catalytically competent active site, demonstrates the significance that the quaternary structural change and closure of the 240s loop has in the functional mechanism of aspartate transcarbamoylase.
Effects of the plasma-facing materials on the negative ionH−density in an ECR (2.45 GHz) plasma (2018)

International audience; Within the framework of fundamental research, the present work focuses on the role of surface material in the production of H− negative ion, with a potential application of designing cesium-free H− negative ion sources oriented to fusion application. It is widely accepted that the main reaction leading to H− production, in the plasma volume, is the dissociative attachment of low-energy electrons (T e ≤ 1 eV) on highly ro-vibrationally excited hydrogen molecules. In parallel with other mechanisms, the density of these excited molecules may be enhanced by means of the recombinative desorption, i.e. the interaction between surface absorbed atoms with other atoms (surface adsorbed or not) through the path Hads + Hgas/ads --&gt; H2(v,J)gas + ΔE. Accordingly, a systematic study on the role played by the surface in this reaction, with respect to the production of H− ion in the plasma volume, is here performed. Thus, tantalum and tungsten (already known as H− enhancers) and quartz (inert surface) materials are employed as inner surfaces of a test bench chamber. The plasma inside the chamber is produced by electron cyclotron resonance (ECR) driving and it is characterized with conventional electrostatic probes, laser photodetachment, and emission and absorption spectroscopy. Two different positions (close to and away from the ECR driving zone) are investigated under various conditions of pressure and power. The experimental results are supported by numerical data generated by a 1D model. The latter couples continuity and electron energy balance equations in the presence of magnetic field, and incorporates vibrational kinetics, H2 molecular reactions, H electronically excited states and ground-state species kinetics. In the light of this study, recombinative desorption has been evidenced as the most probable mechanism, among others, responsible for an enhancement by a factor of about 3.4, at 1.6 Pa and 175 W of microwave power, in the case of tantalum.
Die effektive Öffnung des C60-Gerüsts durch eine ungewöhnliche Reaktionsfolge (1999)

Ein großes Loch in einem Fulleren: Die Addition von Sauerstoff an die äußerst reaktive 1,4-Diaminobutadien-Einheit der Verbindung 1, die durch Reaktion von C60 mit einem starren Diazidobutadien entsteht, führt sehr effizient zur Bildung der bislang größten Öffnung in einem Fullerengerüst (siehe Kalottenmodell). Deren Durchmesser könnte groß genug sein, um kleinen Atomen, Molekülen oder Ionen den Durchtritt zu ermöglichen.
Acaricidal activity of the aqueous and hydroethanolic extracts of 15 South African plants against Rhipicephalus turanicus and their toxicity on human liver and kidney cells (2019)

Hot water and hydroethanolic (70:30) extracts were prepared from 15 plant species, which were investigated to discover eco-friendly and less expensive tick control methods as an alternative to synthetic acaricides. A contact bioassay was used to determine the acaricidal activity of these extracts against the cattle tick, Rhipicephalus turanicus (Acari: Ixodidae) at a concentration of 20% (200 mg/mL). The hydroethanolic extracts had better activity than the hot water extracts against R. turanicus. The hydroethanolic extract from Tabernaemontana elegans (leaves) had the best mortality (87.0%). This was followed by Calpurnia aurea (stems) with a mortality of 75.0%, Schkuhria pinnata (whole plant) with a mortality of 67.0% and Aloe rupestris (leaves) with a mortality of 66.6%. The toxicity of the plant extracts was also investigated and it was found that most of the hydroethanolic and hot water extracts were either safe or very safe on human Vero kidney and liver HepG2 cells. From this study, it was evident that botanicals have the potential to be developed as environmentally benign natural acaricides against R. turanicus.
Response to Hulman and colleagues regarding “Glucotypes reveal new patterns of glucose dysregulation” (2021)

In a response to a Formal Comment critiquing their model for classifying individualized glucose patterns into glucotypes, these authors stand by their results and conclusions, which can be reproduced using their publicly available data, and maintain that improved algorithms for analyzing CGM data will continue to emerge and enrich the field.
The heap-sort based ATM cells spacer (2003)

After situating the spacing function within the context of a multiservices ATM network which carries both isochronous and non-isochronous flows, the paper presents a novel spacing device, based on the classical heap-sort algorithm. Two new aspects of this spacer are: firstly, it is theoretically optimal in complexity; by using log(N) pipelined controllers, the sorter embedded within this spacer is able to sort in a half cell time the N elements situated at the head of N connection related queues, and this is done without very high-speed logic; secondly, it can cope with both real-time services and non-real-time services by combining spacing and weighted fair queuing. Finally, some ATM switch structures making use of the proposed spacer are sketched.
New-found phenolic glycolipids in Mycobacterium bovis BCG (1989)

A crude phenolic glycolipid extract from Mycobacterium bovis bacille Calmette-Guerin (BCG) was fractionated until homogeneity at the intact level into four phenolic glycolipids called B, B-1, B-2, and B-3 according to their polarity. The apolar one, which is the most abundant was assigned to the well-known mycoside B. The B-2 and B-3 phenolic glycolipids were purified by direct-phase high performance liquid chromatography using a 5 micron Spherisorb column but were only recovered in small amounts (3 mg). A linear gradient of 0-20% methanol in chloroform was used. The B-1, B-2, and B-3 glycolipids were subjected to suitable modern analytical techniques selected for their potential to elucidate the structure at the intact level. Desorption chemical ionization-mass spectrometry allowed the molecular mass of B-3 to be determined as 1652 Da for the major homolog establishing the molecular formula as C103H192O14. Thus, the B-3 polar phenolic glycolipid contained two deoxyhexoses, one molecule of phenolphthiocerol esterified by two molecules of mycocerosic acid. Using two-dimensional 1H NMR (correlated chemical shift and nuclear Overhauser effect spectroscopy) at the intact level the B-3 oligosaccharide structure was determined as an alpha-L-Rhap-(1----3)-2-O-Me-alpha-L-Rhap. This is the first report of a diglycosylated phenolic glycolipid in a nonpathogenic mycobacteria. The disaccharide unit, the antigenic determinant, appears to be characteristic of M. bovis BCG. This polar glycolipid B-3 and the apolar ones, B-1 and B-2, were reactive in enzyme-linked immunosorbent assay against serum from rabbit hyperimmunized with M. bovis BCG.
Use of radial arterial tonometric continuous blood pressure measurement in cardiovascular reactivity studies (2002)

Radial tonometric continuous beat-to-beat blood pressure monitoring with the Colin Pilot was associated with a low artifact rating and high accuracy of blood pressure measurement during reactivity testing.
Support agnostic Bayesian recovery of jointly sparse signals (2014)

A matching pursuit method using a Bayesian approach is introduced for recovering a set of sparse signals with common support from a set of their measurements. This method performs Bayesian estimates of joint-sparse signals even when the distribution of active elements is not known. It utilizes only the a priori statistics of noise and the sparsity rate of the signal, which are estimated without user intervention. The method utilizes a greedy approach to determine the approximate MMSE estimate of the joint-sparse signals. Simulation results demonstrate the superiority of the proposed estimator.
Technologiereifebewertung Faserdirektablage zur CFK-Herstellung (2014)

Kurzfassung Kohlenstofffaserverstärkte Kunststoffe (CFK) werden zunehmend in Großserienanwendungen der Automobilindustrie eingesetzt. Neue Fertigungstechnologien, wie z. B. Faserdirektablagetechnologien, haben ein großes Potenzial, die Herstellkosten von CFK zu senken. Um die Wettbewerbsfähigkeit sicherzustellen, müssen jedoch organisatorische und technische Risiken bewertet werden. Der Beitrag beschreibt daher ein Vorgehen zur technologiespezifischen Anpassung eines bestehenden Reifemodells und wendet dieses auf eine Faserdirektablagetechnologie an.
Braeuner (Gabriel), Colmar. L’esprit d’une ville. Éditions du Belvedère, 2011, 205 p. (2012)

Pendant plusieurs annees, Gabriel Braeuner a regulierement delivre un billet sur un aspect historique de Colmar dans un quotidien regional. L’exercice necessite une recherche constante de sujets, pas toujours de premiere main, suffisamment varies pour ne pas engendrer de repetitions, suffisamment cibles pour interesser un lecteur peu familier de Clio. Comme le veut le genre, il faut eviter un texte longuet, ecrire de facon concise et nerveuse, soutenir l’attention afin d’eviter le fatal decro...
Central infusion of leptin into well-fed and undernourished ewe lambs: effects on feed intake and serum concentrations of growth hormone and luteinizing hormone (2001)

Leptin has been implicated in the regulation of feed intake, growth, and reproduction. The objective of this study was to determine if centrally administered leptin would affect feed intake and the secretion of growth hormone (GH) and luteinizing hormone (LH) in ewe lambs. Eighteen ewe lambs were ovariectomized and fitted with intracerebroventricular (i.c.v.) cannulae. Lambs were randomly assigned to receive either a maintenance diet (fed), or a diet that provided 38% of maintenance requirements (diet-restricted) for 14 weeks. Subsequently, recombinant ovine leptin or vehicle was continuously infused, via i.c.v. cannulae, in a linearly increasing dose for 8 days, reaching a maximum of 1.25 microg/kg per h. Feed intake was recorded on days -1 to 7. Blood was collected via jugular cannulae every 10 min for 4 h on days 0, 2, 4, 6 and 8 for the determination of serum leptin, insulin, LH and GH. Leptin suppressed feed intake in fed lambs on days 4 to 7 (P<0.001), but had no effect on feed intake in diet-restricted lambs (P>0.25). Fed lambs had greater serum concentrations of leptin than diet-restricted lambs (P=0.007). Also, although not different on day 0 (pretreatment), on day 8 serum leptin concentrations were greater in leptin-treated lambs than in saline-treated lambs (P=0.003). Insulin was lower in diet-restricted than in fed lambs (P=0.003), but was not affected by leptin treatment (P=0.82). LH pulse frequencies were lower in diet-restricted lambs than in fed lambs (P=0.038), but were not affected by leptin treatment (P=0.85). Mean serum GH was greater in diet-restricted than in fed lambs (P<0.01). In diet-restricted lambs treated with leptin or saline, mean GH did not differ on day 0, but increased in response to leptin treatment (P<0.006). Treatment of fed lambs with leptin did not affect serum GH (P>0.32). From this work, we propose that leptin represents an important functional link between adipose stores and hypothalamic function in ruminants. We demonstrate that leptin concentrations change in response to reduced nutritional status, and that leptin has the ability to regulate multiple physiological processes in lambs, including both feed intake and secretion of GH.
Collapse and large signal modelling of GaAs field effect transistors at 77 K (1994)

A complete electrical characterization of different types of GaAs field effect transistors at liquid nitrogen temperature is performed. The trapping-detrapping mechanisms on deep levels are particularly adressed and a method is proposed to circumvent the collapse phenomenon which otherwise limits the electrical performances. From these measurements a HEMT non-linear model is extracted and is found efficient for the prediction of the large signal power out versus power in characteristic of a cooled HEMT. A further application could be the optimized design of a cooled low phase noise oscillator.