gebhart/patrepeval huggingface dataset:
The Different Effects on Recognition Memory of Perirhinal Kainate and NMDA Glutamate Receptor Antagonism: Implications for Underlying Plasticity Mechanisms (2006)

To investigate the involvement of different types of glutamate receptors in recognition memory, selective antagonists of NMDA and kainate receptors were locally infused into the perirhinal cortex of the rat temporal lobe. Such infusion of a selective kainate receptor antagonist produced an unusual pattern of recognition memory impairment: amnesia after a short (20 min) but not a long (24 h) delay. In contrast, antagonism of perirhinal NMDA glutamate receptors by locally infused AP-5 (2-amino-5-phosphonopentanoic acid) impaired recognition memory after the long but not the short delay. For both drugs, impairment was found when the drug was present during acquisition but not when it was present during retrieval. Experiments in vitro indicate that selective antagonism of NMDA receptors containing NR2A subunits blocks perirhinal long-term potentiation (LTP), whereas antagonism of NMDA receptors containing NR2B subunits blocks long-term depression (LTD). However, recognition memory after a 24 h delay was impaired only when both an NR2A and an NR2B antagonist were infused together, not when either was infused separately. These results establish that kainate receptors have a role in recognition memory that is distinct from that of NMDA receptors, that there must be at least two independent underlying memory mechanisms in the infused region, that this region and no other is necessary for both short-term and long-term familiarity discrimination, and that perirhinal-dependent long-term recognition memory does not rely solely on processes used in NMDA-dependent LTP or LTD (although it might be independently supported by components of each type of process with one substituting for the other).
A novel algorithm for incompressible flow using only a coarse grid projection (2010)

Large scale fluid simulation can be difficult using existing techniques due to the high computational cost of using large grids. We present a novel technique for simulating detailed fluids quickly. Our technique coarsens the Eulerian fluid grid during the pressure solve, allowing for a fast implicit update but still maintaining the resolution obtained with a large grid. This allows our simulations to run at a fraction of the cost of existing techniques while still providing the fine scale structure and details obtained with a full projection. Our algorithm scales well to very large grids and large numbers of processors, allowing for high fidelity simulations that would otherwise be intractable.
Small-Angle Neutron Scattering of a Solvent-Swollen Segmented Polyurethane as a Probe of Solvent Distribution and Polymer Domain Composition (2008)

Segmented polyurethanes consist of alternating rigid aromatic (hard) and flexible (soft) segments that phase separate into hard and soft segment-rich nanodomains. The domain structure results in what has been presumed to be an extended, cross-linked network, giving these materials unique mechanical properties. Because of poor contrast and volume fractions of the discontinuous phase, previous scattering studies have focused on polyurethanes with hard segment contents greater that 30 wt %. This study focused on a commercial poly(ester urethane), Estane 5703, containing only 23 wt % hard segment content. To probe the domain structure and composition, we used small-angle neutron scattering (SANS) with contrast variation methods on bulk samples swollen with deuterated/protonated mixtures of benzene, toluene, or o-, m-, or p-xylene isomers. We used the fluid model and Pedersen’s micelle model to describe the SANS data as a function of contrast. Both the fluid and micelle models consider Estane as a fluid of spherical, discrete domains in a soft segment-rich matrix. The discrete domains have a closest center-to-center approach defined by the Percus−Yevick hard-sphere potential. The micelle model divides the discontinuous domain into a core and a surrounding corona. We find that the micelle model completely described the data, whereas the fluid model required the ad hoc addition of an additional length scale. The models, which were in good agreement with each other, show that in Estane the discrete domains comprised a small fraction, 0.05−0.06, of the sample volume and have a radius of about 5 nm, giving a number density of the order 1017 cm−3. Furthermore, the discrete domains contain a higher hard segment concentration than the matrix, but incorporated only 0.06−0.13 of the hard segment volume. The results also show there is considerable mixing of the hard and soft segments, and there is a significant amount of soft segment in the discrete domains. Using these results, we were able to determine some important factors behind the thermomechanical properties of Estane. Furthermore, we make a critical assessment of the view that the discrete domains are cross-links for a continuous network and forward the hypothesis that the domains are more like filler particles coupled to the matrix by polymer entanglements.
APPENDIX III Lambda Vectors (1983)

In the list of λ vectors (which follows), the estimated positions of the targets for restriction enzymes are listed as base pairs from the left end of the mature DNA of the phage, although in some cases the values may only be reliable to within a few hundred base pairs. The data for many vectors are from Table 1 of Williams and Blattner (1980), those for newer vectors sometimes rely only on their genotypes together with the λ map circulated by F.R. Blattner in 1981. The name of each vector corresponds as closely as possible to that designated by its authors. The numbers indicated in parentheses are references that either describe the original vector or provide informative maps. A complete list of references follows the list.
Quantitation of circulating DNA in the serum of breast cancer patients by real-time PCR (2004)

The purpose of this study was to quantify the level of serum DNA in different groups of primary breast cancer patients and in healthy controls using real-time quantitative PCR in order to determine whether such measurements have diagnostic or prognostic value. A total of 96 serum samples of patients with primary breast cancer before surgery (with positive or negative lymph nodes and with high or low relapse-free survival) as well as 24 healthy controls were analysed. DNA concentrations in the serum of the patients differed significantly from the concentration of serum DNA in the controls (medians were 221 and 63 ng x ml(-1), respectively, P<0.001 M-W test). However, no statistically significant difference was observed between the patient groups (P=0.87, M-W test). The serum DNA levels were elevated independently of the size of primary tumour or lymph node metastases. The overall survival of patients with serum DNA concentrations >221 ng x ml(-1) was better than patients with serum DNA concentration <or=221 ng ml(-1) (Kaplan-Meier, P=0.028).
Planar HTS gradiometers with large baseline (1997)

We have designed an HTS single-layer planar rf double-hole gradiometer with long and well defined baseline up to 5 mm and small washer areas. We measured a gradient field resolution of about 1 pT/(cm/spl middot//spl radic/Hz) above 10 Hz in an unshielded environment. The gradiometer could be operated placed on a swinging pendulum in the geomagnetic field. This permitted a simple demonstration of a movable SQUID system. We placed a SQUID system on a scanning table and performed two-dimensional eddy-current nondestructive evaluation measurements on realistic samples.
Comparing User-Assisted and Automatic Query Translation (2005)

For the 2002 Cross-Language Evaluation Forum Interactive Track, the University of Maryland team focused on query formulation and reformulation.Twelve people performed a total of forty eight searches in the German document collection using English queries.Half of the searches were with user-assisted query translation, and half with fully automatic query translation.For the user-assisted query translation condition, participants were provided two types of cues about the meaning of each translation: a list of other terms with the same translation (potential synonyms), and a sentence in which the word was used in a translationappropriate context.Four searchers performed the official iCLEF task, the other eight searched a smaller collection.Searchers performing the official task were able to make more accurate relevance judgments with user-assisted query translation for three of the four topics.We observed that the number of query iterations seems to vary systematically with topic, system, and collection, and we are analyzing query content and ranked retrieval measures to obtain further insight into these variations in search behavior.
Reversibly Light‐Switchable Wettability of Hybrid Organic/Inorganic Surfaces With Dual Micro‐/Nanoscale Roughness (2009)

Abstract Here, an approach to realize “smart” solid substrates that can convert their wetting behavior between extreme states under selective light irradiation conditions is described. Hybrid organic/inorganic surfaces are engineered by exploiting photolithographically tailored SU‐8 polymer patterns as templates for accommodating closely packed arrays of colloidal anatase TiO 2 nanorods, which are able to respond to UV light by reversibly changing their surface chemistry. The TiO 2 ‐covered SU‐8 substrates are characterized by a dual micro‐/nanoscale roughness, arising from the overlapping of surfactant‐capped inorganic nanorods onto micrometer‐sized polymer pillars. Such combined architectural and chemical surface design enables the achievement of UV‐driven reversible transitions from a highly hydrophobic to a highly hydrophilic condition, with excursions in water contact angle values larger than 100°. The influence of the geometric and compositional parameters of the hybrid surfaces on their wettability behavior is examined and discussed within the frame of the available theoretical models.
Knowledge-based intrusion detection (2003)

The authors describe the expert-system aspects of IDES (intrusion-detection expert system). A system for computer intrusion detection IDES uses two distinct approaches to detect anomalies (which could signify intrusions) in a computer system, namely, statistical and rule-based anomaly detection. In the statistical approach, recent behavior of a subject of a computer system is compared with observed behavior and any significant deviation is considered anomalous. In the rule-based approach, acceptable behaviour of a subject is captured by a set of rules which is used to identify anomalous observed behavior. The authors claim that integrating the two approaches in IDES provides for a comprehensive system for detecting intrusions as they occur.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparison of Material Behavior and Economic Effects of Cold and High Temperature Forming Technologies Applied to High-Strength Steels (2005)

The focus of forming high-strength steel at elevated temperature is to improve its forming properties like elongation and to reduce the power requirements during the forming process in opposite to cold forming. Because of the undefined and large spring-back effects parts made by cold forming are not able to achieve the demanded dimensional accuracy, which is necessary for laser welding operations in car body assembly. The reduction of the spring-back behavior is another advantage of the temperature controlled forming technology. On the other side the forming at elevated temperatures requires increased costs for forming tools and tempering equipment. For a fundamental evaluation of this technology, expenditures for the complete process chain have to be considered.
Mapping QTL affecting resistance to Marek's disease in an F6 advanced intercross population of commercial layer chickens (2009)

There was considerable evidence suggesting that MD resistance alleles tend to be recessive. The width of the QTLR for these QTL appeared to be reduced about two-fold in the F6 as compared to that found in the previous BC study. These results provide a firm basis for high-resolution linkage disequilibrium mapping and positional cloning of the resistance genes.
The Immune Response of Tetraparental Mice to Two Synthetic Amino Acid Polymers: “High-Conjugation” 2,4 Dinitrophenyl-Glutamic Acid57-Lysine38-Alanine5 (DNP-GLA5) and Glutamic Acid60 Alanine30 Tyrosine10 (Gat10) (1973)

Abstract Allophenic (tetraparental) mice of the following types were produced: C57BL/6J ↔ C3H/HeJ, C57BL/6J ↔ DBA/1J, C3H/HeJ ↔ CF1, C3H/HeJ ↔ DBA/1J, C57BL/6J ↔ BALB/cJ, SJL/J ↔ C3H/HeJ, SJL/J ↔ DBA/2J, SJL/J ↔ C57BL/6J, and DBA/1J ↔ A/J. These mice were immunized with 35 or 77 µg of “high-conjugation” (50 to 75%) 2,4 dinitrophenyl-poly (glu57 lys38 ala5), DNP-GLA5, or with 10 µg of poly (glu60 ala30 try10), GAT10. The primary and secondary antibody responses to the DNP group or GAT10 were tested. Many of the mice expressing the presence of “responder” cells, as shown by coat color phenotype, failed to respond to these antigens. We suggest two possible explanations: 1) An allophenic mouse may need a minimum number of responder lymphoid cells in order to respond to an antigen. 2) Cross-tolerance may be responsible for the non-response to some antigens in some strains of mice.
Solid-Liquid Separation of Lanthanide/Lanthanide and Lanthanide/Actinide Using Ionic Imprinted Polymer Based on a DTPA Derivative (2002)

Abstract Competitive extraction of Gd/La, Gd/Nd, Gd/Eu, Gd/Lu and Am/Eu with a gadolinium-imprinted polymer leads to improvement of the selectivity compare to the corresponding blank material.
Water-cooled bimorph correctors (2005)

Water-cooled bimorph mirrors for beam correction and formation in high power CW lasers were developed and investigated. Different type of substrate has been considered to thermally stabilize of the mirror surface shape. Silicon bimorph mirror was tested in ceramic Nd:YAG CW laser.
Crystal Structure of Yeast Thymidylate Kinase Complexed with the Bisubstrate Inhibitor P1-(5‘-Adenosyl) P5-(5‘-Thymidyl) Pentaphosphate (TP5A) at 2.0 Å Resolution:  Implications for Catalysis and AZT Activation, (1998)

The crystal structure of yeast thymidylate kinase (TmpK) complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) was determined at 2.0 A resolution. In this complex, TmpK adopts a closed conformation with a region (LID) of the protein closing upon the substrate and forming a helix. The interactions of TmpK and TP5A strongly suggest that arginine 15, which is located in the phosphate binding loop (P-loop) sequence, plays a catalytic role by interacting with an oxygen atom of the transferred phosphoryl group. Unlike other nucleoside monophosphate kinases where basic residues from the LID region participate in stabilizing the transition state, TmpK lacks such residues in the LID region. We attribute this function to Arg 15 of the P-loop. TmpK plays an important role in the phosphorylation of the AIDS prodrug AZT. The structures of TmpK with dTMP and with AZT-MP [Lavie, A., et al. (1997) Nat. Struct. Biol. 4, 601-604] implicate the movement of Arg15 in response to AZT-MP binding as an important factor in the 200-fold reduced catalytic rate with AZT-MP. TmpK from Escherichia coli lacks this arginine in its P-loop while having basic residues in the LID region. This suggested that, if such a P-loop movement were to occur in the E. coli TmpK upon AZT-MP binding, it should not have such a detrimental effect on catalysis. This hypothesis was tested, and as postulated, E. coli TmpK phosphorylates AZT-MP only 2.5 times slower than dTMP.
Chain Flexibility of Polymethacrylic Systems Bearing Aromatic Polar Groups with Alkylene Spacers As Studied by the Tg of Polymers and Copolymers with 2-Hydroxyethyl Methacrylate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChain Flexibility of Polymethacrylic Systems Bearing Aromatic Polar Groups with Alkylene Spacers As Studied by the Tg of Polymers and Copolymers with 2-Hydroxyethyl MethacrylateBelen Levenfeld and Julio San RomanCite this: Macromolecules 1995, 28, 10, 3650–3656Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://doi.org/10.1021/ma00114a019RIGHTS & PERMISSIONSArticle Views73Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (773 KB) Get e-Alerts Get e-Alerts
Effect of Polymeric IgG on Human Monocyte Functions (1987)

Fc and iC3b receptors are involved in various biological functions of phagocytic cells, such as immune adherence and phagocytosis of opsonized particles, degranulation and superoxide generation. In the present study we examined the expression of specific receptors for the Fc portion of IgG (FcR) and for iC3b (CR3), a cleavage product of the third complement component, on human monocytes following in vitro treatment with polymeric and monomeric IgG. Interaction of polymeric IgG (fluid phase) with the monocyte membrane led to a concomitant modulation of both Fc and iC3b receptors. Monomeric IgG, however, down modulated Fc receptor expression only if surface bound. Under these conditions, no concomitant modulation of the iC3b receptor could be observed. The down modulation of Fc and iC3b receptors induced by fluid-phase IgG polymers was also accompanied by a decrease in monocyte functions as expressed by reduced Fc receptor-mediated phagocytosis, decreased release of oxygen metabolites following stimulation by aggregated IgG and opsonized zymosan, as well as in impaired killing of bacteria. These data suggest that a down modulation of Fc and iC3b receptors might have important implications for host defense mechanisms, since interaction with these receptors is required for the proper elimination of many pathogens.
Integration of HSR and IEEE1588 over Ethernet networks (2010)

Some of the key infrastructure requirements for Smart Grid are the uninterrupted and reliable distribution of network data, information security and distribution of time information among network elements in order to accurately timestamp and correlate different network events. High Availability Seamless Ring (HSR) enabled networks can provide zero recovery time and PTPv2 enabled network can provide sub-microsecond accuracy. Although the integration of HSR and PTPv2 seem a natural next step to achieve high availability and time synchronization requirements of IEC61850, there are some assumptions made in the design of HSR and PTPv2 that are orthogonal in nature. This paper presents an instance of network design that integrates these two technologies by using the subset of PTPv2 without compromising network precision. Information security is beyond the scope of this paper.
A sensor for stiffness change sensing based on three weakly coupled resonators with enhanced sensitivity (2015)

This paper reports on a novel MEMS resonant sensing device consisting of three weakly coupled resonators that can achieve an order of magnitude improvement in sensitivity to stiffness change, compared to current state-of-the-art resonator sensors with similar size and resonant frequency. In a 3 degree-of-freedom (DoF) system, if an external stimulus causes change in the spring stiffness of one resonator, mode localization occurs, leading to a drastic change of mode shape, which can be detected by measuring the modal amplitude ratio change. A 49 times improvement in sensitivity compared to a previously reported 2DoF resonator sensor, and 4 orders of magnitude enhancement compared to a 1DoF resonator sensor has been achieved.
OPTIMUM CONTROL OF TRAFFIC SIGNALS AT CONGESTED INTERSECTIONS (ABRIDGMENT) (1977)

A theory is developed that provides an analytical solution to the problem of optimum control of traffic signals at congested intersections with queue length constraints. The theory is first used with an isolated congested intersection, then extended to a system of two or more intersections. Using two or more does not present any problem because it is a straightforward application of the pair of intersections. As the number of intersections increase or when a large number of queues length constraints are imposed, the optimum control policy becomes more complex. As system and performance requirements increase, closed loop control (computer control) should be considered.
The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction (2021)

Mycoplasma immunoglobulin binding (MIB) and mycoplasma immunoglobulin protease (MIP) are surface proteins found in the majority of mycoplasma species, acting sequentially to capture antibodies and cleave off their V<sub>H</sub> domains. Cryo-electron microscopy structures show how MIB and MIP bind to a Fab fragment in a "hug of death" mechanism. As a result, the orientation of the V<sub>L</sub> and V<sub>H</sub> domains is twisted out of alignment, disrupting the antigen binding site. We also show that MIB-MIP has the ability to promote the dissociation of the antibody-antigen complex. This system is functional in cells and protects mycoplasmas from antibody-mediated agglutination. These results highlight the key role of the MIB-MIP system in immunity evasion by mycoplasmas through an unprecedented mechanism, and open exciting perspectives to use these proteins as potential tools in the antibody field.