gebhart/patrepeval huggingface dataset:
Mechanical Design, Assembly, and Test of LPF1: A 10.2 T Nb3Sn Common-Coil Dipole Magnet With Graded Coil Configuration (2018)

An Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn/NbTi subscale dipole magnet named LPF1 with graded coil design and common-coil configuration has been designed, assembled, and tested at the Institute of High Energy Physics, Beijing, China. Compared to the previously proposed FECD1, LPF1 is designed with a longer outer NbTi racetrack coil to reduce the peak field in the coil end. The computed bore field and peak coil field of LPF1 is 12.0 T and 12.1 T, if it works at 6100 A with a safety margin of 17% at 4.2 K. The horizontal and vertical directions of the coil packs are preloaded by using bladder and key technology while the axial direction of the coil packs is preloaded by pretightening four aluminum rods. Before assembly, we tested the electron-beam welded bladders in a subscale shell-support structure and verified the strain measurement system. During assembly, we preloaded the coil packs gradually by referring to the measured shell strain after inserting stainless steel keys and removing the bladders. After assembly, we started to test the subscale dipole magnet vertically at 4.2 K. LPF1 reached a bore field of 10.2 T after 13 training quenches and then it reached a stable quench current without detraining. This paper presents the updated design parameters, the stress analysis, the magnet assembly, and test of LPF1.
Recombinant interferon beta and gamma in the treatment of adult T-cell leukemia (1987)

Adult T-cell leukemia (ATL) is one of the most difficult diseases to treat because of severe underlying immune deficiency and metabolic disturbance. Interferon has potent antiviral, antiproliferative, and immunomodulating properties, and therefore, this may be a good agent to treat such immune deficient patients with peripheral T-cell leukemia. During a period from April 1984 to August 1985, six patients were treated with interferon-beta (IFN-beta), and interferon-gamma (IFN-gamma) was given to five patients. Three patients achieved partial remission by IFN-beta administration with a response duration of 1, 1.5, and 12 months respectively, whereas one complete remission and two partial responses were experienced by IFN-gamma treatment with 4, 4, and 2 months of response. Side effects of IFN-beta were similar to those of IFN-gamma including fever, chills, fatigue, mild hematologic depression, and transient hepatic enzyme abnormalities. These promising results warrant further well-designed clinical trials including combination with other agents or modalities of treatment.
VTArtWorks White Paper (2016)

VTArtWorks, an interdisciplinary team at Virginia Tech focused on serving the field of Community Cultural Development (CCD) through innovative web technology, began working together in the fall of 2015 thanks to a generous grant from the Institute of Museum and Library Services (IMLS). From the fall of 2015 to the summer of 2016 the VTArtWorks team has performed original research with the eventual goal of informing development of an online communication platform for the field of CCD.
Methanol Marker for the Detection of Insulating Paper Degradation in Transformer Insulating Oil (2019)

This manuscript presents a comprehensive literature review with the aim to provide readers a reference document with up-to-date information on the field of methanol use as a chemical marker. It has been a little more than a decade since methanol was first introduced as a marker for assessing solid insulation condition in power transformers. It all started when methanol was identified in the laboratory during thermal ageing tests carried out with oil-immersed insulating papers and was subsequently also identified in transformer field samples. The first publication on the subject was released in 2007 by our research group. This review covers the methanol fundamentals such as the analytical methods for its determination in transformer oil, which is generally performed by headspace gas chromatography with mass spectrometry or flame ionization as a detector. Current standardization efforts for its determination include ASTM working group 30948 and IEC TC10. Kinetic studies have confirmed the relationship between methanol generation, the number of broken 1,4-β-glycosidic bonds of cellulose and changes in mechanical properties. Laboratory tests have confirmed its stability at different accelerated ageing temperatures. Several utilities have identified methanol during field measurements, case studies on power and some distribution transformers are presented, as well as transformer postmortem investigations. These field-testing results demonstrate its utility in monitoring cellulosic insulation degradation. Recently, a model of methanol interpretation has become available that allows for evaluation of the average degree of polymerization of core type transformer cellulose winding. Methanol has a role as an indicator of cellulosic solid insulation ageing in transformer mineral oil, and it is expected that in the future it will be in routine use by utilities.
ChemInform Abstract: DIE 9‐FLUORENYLMETHOXYCARBONYL‐GRUPPE ALS AMIN‐SCHUTZGRUPPE (1973)

Abstract 9‐Fluorenylmethanol (I) liefert mit Phosgen glatt den Chlorkohlensäureester (II), der bei der Behandlung mit Aminen (III) zu den 9‐Fluorenylmethoxycarbonyl‐Verbindungen (IV) umgesetzt werden kann.
How I became myself after merging with a computer: Does human-machine symbiosis raise human rights issues? (2023)

Novel usages of brain stimulation combined with artificially intelligent (AI) systems promise to address a large range of diseases. These new conjoined technologies, such as brain-computer interfaces (BCI), are increasingly used in experimental and clinical settings to predict and alleviate symptoms of various neurological and psychiatric disorders. Due to their reliance on AI algorithms for feature extraction and classification, these BCI systems enable a novel, unprecedented, and direct connection between human cognition and artificial information processing. In this paper, we present the results of a study that investigates the phenomenology of human-machine symbiosis during a first-in-human experimental BCI trial designed to predict epileptic seizures. We employed qualitative semi-structured interviews to collect user experience data from a participant over a six-years period. We report on a clinical case where a specific embodied phenomenology emerged: namely, after BCI implantation, the patient reported experiences of increased agential capacity and continuity; and after device explantation, the patient reported persistent traumatic harms linked to agential discontinuity. To our knowledge, this is the first reported clinical case of a patient experiencing persistent agential discontinuity due to BCI explantation and potential evidence of an infringement on patient right, where the implanted person was robbed of her de novo agential capacities when the device was removed.
Integration-ready version of AI algorithms to traverse the parametric solution space (2021)

This document describes the integration-ready version of AI algorithms to traverse the parametric solution space. The software deliverable includes the generative algorithms which explore the parametric space guided by constraints, objectives and diversity measures defined in D2.1. The algorithms can generate solutions from scratch, or adapt the user’s own designs, using artificial evolution, constrained optimization, and quality-diversity search.
Precisely determining photon-number in real time (2024)

Superconducting transition-edge sensors (TES) are extremely sensitive microcalorimeters used as photon detectors with unparalleled energy resolution. They have found application from measuring astronomical spectra through to determining the quantum property of photon-number, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mover><mml:mi>n</mml:mi><mml:mo stretchy="false">&amp;#x005E;</mml:mo></mml:mover></mml:mrow><mml:mrow class="MJX-TeXAtom-ORD"><mml:mo>=</mml:mo></mml:mrow><mml:msup><mml:mrow class="MJX-TeXAtom-ORD"><mml:mover><mml:mi>a</mml:mi><mml:mo stretchy="false">&amp;#x005E;</mml:mo></mml:mover></mml:mrow><mml:mo>&amp;#x2020;</mml:mo></mml:msup><mml:mrow class="MJX-TeXAtom-ORD"><mml:mover><mml:mi>a</mml:mi><mml:mo stretchy="false">&amp;#x005E;</mml:mo></mml:mover></mml:mrow></mml:math>, for energies from 0.6-2.33eV. However, achieving optimal energy resolution requires considerable data acquisition – on the order of 1GB/min – followed by post-processing, which does not allow access to energy information in real time. Here we use a custom hardware processor to process TES pulses while new detections are still being registered, allowing photon-number to be measured in real time as well as reducing data requirements by orders-of-magnitude. We resolve photon number up to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>16</mml:mn></mml:math> – achieving up to parts-per-billion discrimination for low photon numbers on the fly – providing transformational capacity for applications of TES detectors from astronomy through to quantum technology.
α2-Macroglobulin Exposure Reduces Calcium Responses to N-Methyl-d-Aspartate via Low Density Lipoprotein Receptor-related Protein in Cultured Hippocampal Neurons (2002)

There is increasing evidence that the low-density lipoprotein receptor-related protein (LRP) can function as a signaling link in the central nervous system. To investigate the pathophysiological role of LRP in the central nervous system, we examined the effects of activated alpha(2)-macroglobulin (alpha2M*), a ligand of LRP, on intracellular calcium signaling in cultured rat hippocampal neurons. Neuronal effects of alpha2M* (50 nm) were assessed by a comparison of calcium signals produced in control and alpha2M*-pretreated neurons by N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid. alpha2M* pretreatment significantly decreased the calcium signals to NMDA, whereas little change was observed for the signals to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid. Native alpha2M, which is not a ligand for LRP, did not affect signals to NMDA. The receptor-associated protein prevented alpha2M*-induced decrease of calcium responses to NMDA, suggesting that alpha2M* exerted its effects through an LRP-mediated pathway. Experiments changing calcium sources demonstrated that alpha2M* pretreatment altered calcium responses to NMDA by primarily changing extracellular calcium influx and subsequently affecting calcium release from intracellular calcium stores. Immunoblot analysis demonstrated that alpha2M* caused a reduction in the levels of the NMDA receptor subunit, NMDAR1. These results suggest that alpha2M* can alter the neuronal response to excitatory neurotransmitters and that alpha2M* pretreatment selectively reduced the calcium responses to NMDA by down-regulating the NMDA receptor.
Physical and genetic map of the chromosome of the unicellular cyanobacterium Synechocystis sp. strain PCC 6803 (1995)

A combined physical and genetic map of the cyanobacterium Synechocystis sp. strain PCC 6803 chromosome was constructed. An estimated genome size of 3.82 Mb was obtained by summing the sizes of 25 MluI or 40 NotI fragments seen by pulsed-field electrophoresis. The order of the restriction fragments was determined by using two independent experimental approaches: pulsed-field fragment hybridization and linking clone analysis. The relative positions of 30 known genes or gene clusters were localized.
Plant members of a family of sulfate transporters reveal functional subtypes. (1995)

Three plant sulfate transporter cDNAs have been isolated by complementation of a yeast mutant with a cDNA library derived from the tropical forage legume Stylosanthes hamata. Two of these cDNAs, shst1 and shst2, encode high-affinity H+/sulfate cotransporters that mediate the uptake of sulfate by plant roots from low concentrations of sulfate in the soil solution. The third, shst3, represents a different subtype encoding a lower affinity H+/sulfate cotransporter, which may be involved in the internal transport of sulfate between cellular or subcellular compartments within the plant. The steady-state level of mRNA corresponding to both subtypes is subject to regulation by signals that ultimately respond to the external sulfate supply. These cDNAs represent the identification of plant members of a family of related sulfate transporter proteins whose sequences exhibit significant amino acid conservation in filamentous fungi, yeast, plants, and mammals.
A Feature Dictionary for a Multi-Domain Medical Knowledge Base. (1988)

Because different terminology is used by physicians of different specialties in different locations to refer to the same feature (signs, symptoms, test results), it is essential that our knowledge development tools provide a means to access a common pool of terms. This paper discusses the design of an online medical dictionary that provides a solution to this problem for developers of multi-domain knowledge bases for MEDAS (Medical Emergency Decision Assistance System). This Feature Dictionary supports phrase equivalents for features, feature interactions, feature classifications, and translations to the binary features generated by the expert during knowledge creation. It is also used in the conversion of a domain knowledge to the database used by the MEDAS inference diagnostic sessions. The Feature Dictionary also provides capabilities for complex queries across multiple domains using the supported relations. The Feature Dictionary supports three methods for feature representation: 1) binary, 2) continuous valued, and 3) derived.
Representation and coding of large-scale 3D dynamic maps (2016)

combined with depth and color measurements of the surrounding environment. Localization could be achieved with GPS, inertial measurement units (IMU), cameras, or combinations of these and other devices, while the depth measurements could be achieved with time-of-flight, radar or laser scanning systems. The resulting 3D maps, which are composed of 3D point clouds with various attributes, could be used for a variety of applications, including finding your way around indoor spaces, navigating vehicles around a city, space planning, topographical surveying or public surveying of infrastructure and roads, augmented reality, immersive online experiences, and much more. This paper discusses application requirements related to the representation and coding of large-scale 3D dynamic maps. In particular, we address requirements related to different types of acquisition environments, scalability in terms of progressive transmission and efficiently rendering different levels of details, as well as key attributes to be included in the representation. Additionally, an overview of recently developed coding techniques is presented, including an assessment of current performance. Finally, technical challenges and needs for future standardization are discussed.
Alteration of human pain thresholds by nutritional manipulation and l-tryptophan supplementation (1982)

Pain perception and tolerance thresholds of 30 normal subjects were determined by electrical stimulation of dental pulps before and after dietary manipulation which included either tryptophan supplementation or placebo. Perception threshold levels were similar in tryptophan and placebo subjects; however, pain tolerance levels were significantly higher in the group receiving tryptophan. Side effects such as nausea, skin itching, weight loss and mood elevation were more common in the tryptophan group than in the placebo group.
Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C (2021)

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this variation being associated with differences in the onset and progression of some human diseases. However, the molecular bases underlying these associations remain unresolved. Here, we determined the crystal structures of KIR2DL2 and KIR2DL3 in complex with HLA-C*07:02 presenting a self-epitope. KIR2DL2 differed from KIR2DL3 in docking modality over HLA-C*07:02 that correlates with variabilty of recognition of HLA-C1 allotypes. Mutagenesis assays indicated differences in the mechanism of HLA-C1 allotype recognition by KIR2DL2 and KIR2DL3. Similarly, HLA-C1 allotypes differed markedly in their capacity to inhibit activation of primary NK cells. These functional differences derive, in part, from KIR2DS2 suggesting KIR2DL2 and KIR2DL3 binding geometries combine with other factors to distinguish HLA-C1 functional recognition.
SpineCore treatment for early scoliosis: 15° to 24° (2009)

The purpose of this prospective observational study was to evaluate the effectiveness of the Dynamic SpineCor brace for early adolescent idiopathic scoliosis following the outcome SRS criteria.
On the Energy-Spectral Efficiency Trade-off of the MRC Receiver in Massive MIMO Systems with Transceiver Power Consumption (2014)

We consider the uplink of a multiuser massive MIMO system wherein a base station (BS) having $M$ antennas communicates coherently with $K$ single antenna user terminals (UTs). We study the energy efficiency of this system while taking the transceiver power consumption at the UTs and the BS into consideration. For a given spectral efficiency $R$ and fixed transceiver power consumption parameters, we propose and analyze the problem of maximizing the energy efficiency as a function of $(M,K)$. For the maximum ratio combining (MRC) detector at the BS we show that with increasing $R$, $(M,K)$ can be adaptively increased in such a way that the energy efficiency converges to a positive constant as $R \rightarrow \infty$ ($(M,K)$ is increased in such a way that a constant per-user spectral efficiency $R/K$ is maintained). This is in contrast to the fixed $(M,K)$ scenario where the energy efficiency is known to converge to zero as $R \rightarrow \infty$. We also observe that for large $R$, the optimal $(M,K)$ maximizing the energy efficiency is such that, the total power consumed by the power amplifiers (PA) in all the $K$ UTs is a small fraction of the total system power consumption.
Linkage mapping an indoxacarb resistance locus in Helicoverpa armigera (Lepidoptera: Noctuidae) by genotype‐by‐sequencing (2019)

We mapped indoxacarb resistance in GY7-39 to two closely linked loci IndoR1 and IndoR2 in a narrowed 2.6 Mbp region of H. armigera chromosome 16. The results provide essential background data for future genetic investigations including fine mapping of the indoxacarb resistance gene and the eventual development of an effective DNA-based diagnostic to support resistance management. © 2019 Society of Chemical Industry.
“Dopamine homeostasis” requires balanced polypharmacy: Issue with destructive, powerful dopamine agents to combat America’s drug epidemic (2017)

The well-researched pro-dopamine regulator KB220 and variants result in increased functional connectivity in both animal and human brains, and prolonged neuroplasticity (brain cell repair) having been observed in rodents. Moreover, in addition to increased functional connectivity, recent studies show that KB220Z increases overall brain connectivity volume, enhances neuronal dopamine firing, and eliminates lucid dreams in humans over a prolonged period. An unprecedented number of clinical studies validating this patented nutrigenomic technology in re-balancing brain chemistry and optimizing dopamine sensitivity and function have been published. On another note, it is sad that unsuspecting consumers could be deceived and endangered by false promises of knock-off marketers with look- and- sound-alike products. Products containing ingredients having potential dangers (i.e., combinations of potent D2 agonists including L-Dopa and L-Theanine) threaten the credibility and reputation of validated, authentic, and ethical products. We encourage clinicians and neuroscientists to continue to embrace the concept of "dopamine homeostasis" and search for safe, effective, validated and authentic means to achieve a lifetime of recovery, instead of reverting to anti-dopaminergic agents doomed to fail in the war against the devastating drug epidemic, or promoting powerful D2 agonists that compromise needed balance.
Effect of Grafted Oligopeptides on Friction (2013)

Frictional and normal forces in aqueous solution at 25 °C were measured between a glass particle and oligopeptide films grafted from a glass plate. Homopeptide molecules consisting of 11 monomers of either glutamine, leucine, glutamic acid, lysine, or phenylalanine and one heteropolymer were each "grafted from" an oxidized silicon wafer using microwave-assisted solid-phase peptide synthesis. The peptide films were characterized using X-ray photoelectron spectroscopy and secondary ion mass spectrometry. Frictional force measurements showed that the oligopeptides increased the magnitude of friction compared to that on a bare hydrophilic silicon wafer but that the friction was a strong function of the nature of the monomer unit. Overall we find that the friction is lower for more hydrophilic films. For example, the most hydrophobic monomer, leucine, exhibited the highest friction whereas the hydrophilic monomer, polyglutamic acid, exhibited the lowest friction at zero load. When the two surfaces had opposite charges, there was a strong attraction, adhesion, and high friction between the surfaces. Friction for all polymers was lower in phosphate-buffered saline than in pure water, which was attributed to lubrication via hydrated salt ions.
Stochastic bandits with pathwise constraints (2011)

We consider the problem of stochastic bandits, with the goal of maximizing a reward while satisfying pathwise constraints. The motivation for this problem comes from cognitive radio networks, in which agents need to choose between different transmission profiles to maximize throughput under certain operational constraints such as limited average power. Stochastic bandits serve as a natural model for an unknown, stationary environment. We propose an algorithm, based on a steering approach, and analyze its regret with respect to the optimal stationary policy that knows the statistics of the different arms.
Detection of subacromial bursa thickening by sonography in shoulder impingement syndrome. (2007)

Increased bursa thickness in the symptomatic side may be an alternative sonographic indicator of subacromial bursitis and partial-thickness rotator cuff tears, even when measured to be less than 2 mm. Sonographic examination of subacromial bursa thickness is not an appropriate technique to differentiate the Neer stages I and II impingement. Further study is needed to quantify the echogenicity of the supraspinatus tendon and to show a level of accuracy in patients with rotator cuff tendinosis or partial tears.