gebhart/patrepeval huggingface dataset:
A clinically useful approach to enhance immunological memory and antitumor immunity (2014)

Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
NT-ProBNP Levels in Saliva and Its Clinical Relevance to Heart Failure (2012)

We have firstly demonstrated that NT-proBNP can be detected in saliva and that the levels were higher in heart failure patients compared with healthy control subjects. Further studies will be needed to demonstrate the clinical relevance of salivary NT-proBNP in unselected, previously undiagnosed populations.
Harmonic torque suppression by manual voltage injection (2010)

A method of suppressing the harmonic torques of electrical machines is presented. Three different saturated motors are simulated using finite element analysis. Harmonic voltages are introduced in the supply voltage in order to eliminate the air-gap harmonic torques. The harmonic voltages were selected manually based on basic electrical machine theory. The results show that torque ripple decreases significantly. Torque ripple could be totally removed with modern frequency converters in order to produce smooth torque. This would be beneficial especially in traction motor applications as well as in metal applications, where smooth torque guarantees better quality.
The World of Books (1987)

South Africa Without Apartheid: Dismantling Racial Domination. By Heribert Adam and Kogila Moodley. Berkeley, Los Angeles, and London: University of California Press, 1986. Move Your Shadow: South Africa Black and White. By Joseph Lelyveld. New York, N.Y.: Times Books, 1985. Kaffir Boy: The True Story of a Black Youth Coming of Age in Apartheid South Africa. By Mark Mathabane. New York, N.Y.: MacMillan Publishing Co., 1986. The Political Mythology of Apartheid. By Leonard Thompson. New Haven, Conn., and London: Yale University Press, 1985. By Pauline H. Baker The Media Elite By S. Robert Lichter, Stanley Rothman, and Linda S. Lichter. Bethesda, Md.: Adler & Adler, Publishers, Inc., 1986. By David Gergen
Adrenal Cortical Carcinoma Associated With Lynch Syndrome: A Case Report and Review of Literature (2019)

ACC can be the only manifestation of LS. A best case-detection approach for ACC in the asymptomatic patient with LS is unclear, however urine steroid profiling could be considered.
Changes in the association between postpartum depression and mother-infant bonding by parity: Longitudinal results from the Japan Environment and Children's Study (2018)

The results of several epidemiological studies have shown a moderate association between postpartum depression (PPD) and mother-infant bonding (MIB); however, associations and changes that longitudinally considered parity were not reported. We investigated the possible association between PPD and MIB at one month after birth, in addition, the changes of these indices by parity. From a dataset comprising 103,099 maternal registrations in The Japan Environment and Children's Study, the present study analyzed complete data on questionnaires for 76,363 women who participated once (cross-sectional group) and 3753 women who participated twice (follow-up subgroup). Edinburgh Postnatal Depression Scale (EPDS) scores and the Mother-to-Infant Bonding Scale-Japan (MIBS-J) scores were obtained one month after delivery. We identified the two factors of the MIBS-J, "lack of maternal feeling (LMF)" and "anxiety about caregiving (AC)" through confirmatory factor analysis. Associations between total EPDS and each factor of MIBS-J were evaluated using multiple regression analyses after adjusting for potential confounders. Total EPDS and both factors (LMF and AC) were positively related in the cross-sectional group (fully adjusted β = 0.26 and 0.39 for LMF and AC, respectively), in the follow-up subgroup at first participation (0.24 and 0.40, respectively) and at the second participation (0.25 and 0.39, respectively). Multiple regression analyses revealed a robust, moderate relationship between postpartum depression and mother-infant bonding. PPD and MIB scores were shown to decrease from the first child to the second in the follow-up subgroup. Consequently, interventions which would increase a mother's child care experience and expertise would prevent PPD and improve MIB.
Genetic Expression Analysis To Detect Type Of Leukemia Using Machine Learning (2019)

One of the worst epidemics in the history of mankind is the deadly disease known as cancer. There are several types of cancer and the one that is more commonly heard of these days is leukemia. There are two types of leukemia - acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) - and the purpose of this study is to take into account the gene expression data of several people and predict what type of leukemia they have by using three machine learning algorithms, XGBoost, Random Forest Classification and Artificial Neural Networks. The dataset's dimensionality was reduced using principal component analysis (PCA) before using the algorithms on them.
Web Information Retrieval in Collaborative Tagging Systems (2006)

Collaborative tagging on the Web has been quickly gaining ground as a new paradigm for Web information retrieval, discovering and filtering. There are a number of successful deployments of collaborative tagging systems that effectively recruits the activity of human users into collecting and annotating vast amounts of Web resources. They lead to an emergent categorization of Web resources in terms of tags, and create a different kind of Web directory. However, the current ways of exploration in the tagging space are limited, which cannot get the most out of the real value of it. This paper presents our methodology, observations, and experimental results in the way we propose how to improve the user experience in exploring information captured by collaborative tagging systems
Low-frequency noise behavior of graded-channel SOI n-MOSFETs (2007)

It is shown that the low-frequency noise in graded-channel (GC) SOI nMOSFETs is generally of the flicker or 1/f noise type. The corresponding input-referred noise spectral density is markedly higher than for the conventional uniformly doped or the intrinsic un-doped fully depleted n-channel SOI transistors. However, this increase can only be partially explained by the effective channel length reduction provided by the lightly doped region of the GC structure. It is furthermore demonstrated that the underlying noise mechanism for the GC structures is rather related to carrier number fluctuations compared with mobility fluctuations for the intrinsic or the uniformly doped fully depleted device. It is concluded that for optimal analog performance of GC SOI nMOSFETs, high gain has to be traded off for higher 1/f noise.
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival (2010)

Hemoconcentration is significantly associated with measures of aggressive fluid removal and deterioration in renal function. Despite this relationship, hemoconcentration is associated with substantially improved survival. These observations raise the question of whether aggressive decongestion, even in the setting of worsening renal function, can positively affect survival.
Antibody to Capsular Polysaccharide ofStreptococcus pneumoniaeat the Time of Hospital Admission for Pneumococcal Pneumonia (2000)

IgG to capsular polysaccharide (CPS) of Streptococcus pneumoniae is thought to provide the greatest degree of protection against pneumococcal disease. Serum obtained at hospital admission from 14 (27%) of 51 patients with bacteremic pneumococcal pneumonia and 11 (37%) of 30 with nonbacteremic pneumococcal pneumonia contained IgG to CPS of the infecting serotype; these percentages are similar to the prevalence of IgG to CPS in a control population. However, when compared with antibody from healthy adults, this IgG had far less capacity to opsonize the infecting pneumococcal serotype for phagocytosis in vitro by normal human polymorphonuclear leukocytes or to protect mice against experimental challenge. Failure to opsonize correlated closely with failure to protect mice, and each of these parameters correlated well with poor avidity for CPS. Future vaccine studies may need to examine the functional capacity of antibodies as a surrogate for infection, in addition to measuring their concentration in serum.
Electrochemistry of Copper in Aqueous Ethylenediamine Solutions (2002)

Potential-pH equilibria and potentiodynamic polarization studies were used to examine the electrochemical behavior of copper in aqueous ethylenediamine solutions. Potential-pH diagrams for the copper-water-ethylenediamine system were derived at different total copper and ethylenediamine activities. The diagrams show that the solubility range of copper is significantly extended in the presence of ethylenediamine. Polarization experiments were conducted in deaerated and aerated aqueous solutions of ethylenediamine with cupric sulfate, and ethylenediamine with cupric sulfate over a wide pH range. The results of these experiments are discussed in terms of relevant potential-pH diagrams. Good correlations were observed. © 2002 The Electrochemical Society. All rights reserved.
Rapid Detection of Subtype-Selective Nuclear Hormone Receptor Binding with Bacterial Genetic Selection (2005)

Subtype-selective nuclear hormone receptor modulators could potentially allow the development of valuable tissue-specific therapeutics. A simple biosensor that allows subtype-specific nuclear hormone receptor binding to be reflected by the growth phenotype of Escherichia coli cells has been constructed. This system will potentially enable the facile detection or evolution of subtype-selective hormone analogues.
Revisiting [PtCl2(cis-1,4-DACH)]: An Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-Refractory Colorectal Cancer (2012)

Although the encouraging antitumor activity of [PtCl(2)(cis-1,4-DACH)] (1; DACH = diaminocyclohexane) was shown in early studies almost 20 years ago, the compound has remained nearly neglected. In contrast, oxaliplatin, containing the isomeric 1(R),2(R)-DACH carrier ligand, enjoys worldwide clinic application as a most important therapeutic agent in the treatment of colorectal cancer. By extending the investigation to human chemotherapy-resistant cancer cells, we have demonstrated the real effectiveness of 1 in circumventing cisplatin and oxaliplatin resistance in LoVo colon cancer cells. The uptake of compound 1 by the latter cells was similar to that of sensitive LoVo cells. This is not the case for all other compounds considered in this investigation. Interaction with double-stranded DNA, investigated by a biosensor assay and by quantum mechanical/molecular mechanical geometry optimization of the 1,2-GG intrastrand cross-link, does not show significant differences between 1 and oxaliplatin. However, the DNA adducts of 1 are removed from repair systems with lower efficiency and are more effective in inhibiting DNA and RNA polymerase.
Oxidative stress and pharmacologic quercetin during intense exercise (2007)

This study examined the effect of pharmacologic doses of the polyphenolic antioxidant quercetin on oxidative stress after 3‐days of intense cycling. Forty male endurance athletes were recruited and randomized to a quercetin (Q) or placebo (P) group. Subjects consumed 1000mg quercetin or placebo dissolved in 6 oz of Tang orange drink for six‐weeks prior to, during the 3‐days of cycling at at 57% Watts maximum for 3‐h, and for two weeks afterwards. Blood samples were collected pre‐exercise and immediately post‐exercise on each day and analyzed for F2‐isoprostanes, nitrite, ferric reducing ability of plasma (FRAP), and Trolox Equivalent Antioxidant Capacity (TEAC). A 2 (treatment) x 6 (times) repeated measures ANOVA was used for statistical analyses. F2‐isoprostanes, nitrite, FRAP, and TEAC were significantly elevated as a result of exercise but no group effects were found. Significant but weak positive correlations existed between F2‐isoprostanes, FRAP, and TEAC with quercetin and between F2‐isoprostanes and TEAC with placebo. Administration of pharmacologic doses of quercetin does not exert protection from exercise‐induced oxidative stress. Supported by a grant from DARPA, award number W911NF‐06‐0014.
Large Electric Polarization and Exchange Bias in Multiferroic BiFeO3 (2006)

Low-leakage BiFeO3 films have been grown with saturated ferroelectric hysteresis loops (see figure) and a very large remanent polarization. The antiferromagnetic nature of BiFeO3 films is confirmed by the appearance of an exchange bias in BiFeO3-based spin-valve multilayers. The results imply that there is potential for room-temperature applications of BiFeO3 that combine ferroelectric and antiferromagnetic functionality.
L’Ultrastructure des plaquettes thrombasthéniques (Effets de l’ADP et du fibrinogène bovin) (1967)

Résumé L’ultrastructure des thrombocytes de 7 patients atteints de thrombasthénie, préparés immédiatement après le prélèvement, a été étudiée systématiquement. Un nombre variable des thrombocytes de chacun de ces prélèvements contient des gouttelettes lipidiques et des granulations denses de morphologie inhabituelle, caractères qui ont été décrits précédemment par plusieurs auteurs comme « indices morphologiques d’un état pathologique des thrombocytes », et que l’on sait ne pouvoir être considérés comme pathognomoniques. Néanmoins, l’étude ultrastructurale permet d’envisager une subdivision de ces patients en 2 groupes distincts, subdivision comparable à celle que fournit l’étude enzymatique et immuno-électrophorétique des plaquettes des mêmes patients. De plus, une proportion élevée des thrombocytes de chaque prélèvement contient des organites inhabituels, tels que mitochondries de grande taille, vacuoles multivésiculaires et granulations denses « en oeil de boeuf », qui peuvent être considérés comme l’indice d’un trouble ou d’une déficience de la thrombopoïèse. L’incubation de dix PRP thrombasthéniques en présence d’une forte quantité d’ADP met en évidence une certaine tendance à la micro-agrégation, variable de cas en cas, ainsi qu’une discrète modification de la structure de la membrane périphérique plaquettaire aux points d’accolement des thrombocytes entre eux. L’incubation de deux PRP thrombasthéniques en présence de fibrinogène bovin provoque une « agrégation » particulière qui se manifeste, au microscope électronique, par la présence de dépôts d’une « substance-ciment » interthrombocytaire, sans modification de la structure des membranes périphériques plaquettaires. Ces expériences paraissent confirmer que l’ADP agit réellement sur la plaquette thrombasthénique ; les rapports qui pourraient exister cependant entre ces modifications morphologiques et celles provoquées sur le profil protéique dell’extrait plaquettaire par ce même nucléotide restent encore à préciser.
Accelerated Discovery in Photocatalysis using a Mechanism‐Based Screening Method (2016)

Herein, we report a conceptually novel mechanism-based screening approach to accelerate discovery in photocatalysis. In contrast to most screening methods, which consider reactions as discrete entities, this approach instead focuses on a single constituent mechanistic step of a catalytic reaction. Using luminescence spectroscopy to investigate the key quenching step in photocatalytic reactions, an initial screen of 100 compounds led to the discovery of two promising substrate classes. Moreover, a second, more focused screen provided mechanistic insights useful in developing proof-of-concept reactions. Overall, this fast and straightforward approach both facilitated the discovery and aided the development of new light-promoted reactions and suggests that mechanism-based screening strategies could become useful tools in the hunt for new reactivity.
Data mining techniques for effective and scalable traffic analysis (2005)

This paper describes a novel approach to traffic analysis in high speed networks based on data mining techniques. Data mining techniques are here applied as a means to effectively process the significant amount of captured data. The paper provides a first evaluation of the proposed approach in terms of its ability of extracting relevant information and its computational requirements. Such evaluation is based on experiments run on a prototypal implementation of the proposed approach.
DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders (2012)

Genetic risk factors for major psychiatric disorders play key roles in neurodevelopment. Thus, exploring the molecular pathways of risk genes is important not only for understanding the molecular mechanisms underlying brain development, but also to decipher how genetic disturbances affect brain maturation and functioning relevant to major mental illnesses. During the last decade, there has been significant progress in determining the mechanisms whereby risk genes impact brain development. Nonetheless, given that the majority of psychiatric disorders have etiological complexities encompassing multiple risk genes and environmental factors, the biological mechanisms of these diseases remain poorly understood. How can we move forward to our research for discovery of the biological markers and novel therapeutic targets for major mental disorders? Here we review recent progress in the neurobiology of disrupted in schizophrenia 1 (DISC1), a major risk gene for major mental disorders, with a particular focus on its roles in cerebral cortex development. Convergent findings implicate DISC1 as part of a large, multi-step pathway implicated in various cellular processes and signal transduction. We discuss links between the DISC1 pathway and environmental factors, such as immune/inflammatory responses, which may suggest novel therapeutic targets. Existing treatments for major mental disorders are hampered by a limited number of pharmacological targets. Consequently, elucidation of the DISC1 pathway, and its association with neuropsychiatric disorders, may offer hope for novel treatment interventions.
A New Formulation of Fenofibrate: Suprabioavailable Tablets (2000)

The rationale for, and development of, a new suprabioavailable fenofibrate tablet formulation is described. The new suprabioavailable tablet formulation combines well-established micronisation technology with a new micro-coating process. The new formulation provides more predictable and reliable drug absorption. Owing to the strong relationship between the fenofibrate dissolution performance and its oral bioavailability, equivalent plasma levels of active principal are achieved at a lower dose, with less inter-subject variability and a reduced food effect. The new suprabioavailable tablet may, therefore, be a more efficient and better tolerated formulation.
Multilocus Genotypes Determined by Enzyme Electrophoresis of Neisseria meningitidis Isolated from Patients with Systemic Disease and from Healthy Carriers (1986)

Variation in nine enzymes in 152 isolates of Neisseria meningitidis from Norway (118 from blood or cerebrospinal fluid of patients with systemic disease and 34 from the pharynx of healthy carriers) was analysed by starch-gel electrophoresis. All nine enzymes were polymorphic and the number of allozymes (electromorphs) identified per locus ranged from 3 to 12, with a mean of 6.1. Among the 152 isolates, 55 unique combinations of electromorphs (electrophoretic types, ETs) were distinguished. Twenty ETs were represented among the carrier isolates and 37 among the systemic isolates; hence, only two ETs were found in both groups of isolates. ET-5 was identified 67 times among the 118 systemic isolates (58%), indicating an association of this ET with invasiveness; ET-5 was also the most common type among the carrier isolates (18%). Genetic similarity between ETs was analysed by pairwise comparison of all 55 ETs with respect to the number of electromorphs by which they differed. No evidence of a general genetic difference between carrier and case isolates was found. Two well-defined clusters of ETs were observed, each including one of the two most common ETs identified among the systemic isolates (ET-5 and ET-37), together with isolates differing from them only at one or two loci. All isolates of ET-5 and ET-37, as well as their closely related variants defined by the similarity matrix, were resistant to sulphonamide, independent of their antigenic characteristics and isolation site. The extensive allozyme variation among isolates of the same serogroup demonstrated the limited value of serogrouping as an epidemiological tool. All but one isolate of serotype 15:P1.16 were electrophoretically similar, as were all the 2a:P1.2 isolates. The 15:P1.15 isolates, however, were genetically heterogeneous. The distribution of alleles in genotypes identified among the systemic isolates indicated that genetic recombination may occur in natural populations of N. meningitidis.
Epitaxial Growth of AgxCu1−xI on Al2O3(0001) (2023)

The cover image shows X-ray diffraction patterns of γ-phase AgxCu1–xI films with Ag content up to 52% epitaxially grown on (0001)-oriented Al2O3 by a close distance sublimation technique, reflecting the key message of article number 2200493 by Evgeny Krüger et al. In addition to the 2Θ-ω-scans on the left, the Φ-scans on the right illustrate the in-plane orientation of the layers as well as the absence of an additional β-phase. The gradient bar on the left, connecting the symbols for silver and copper, indicates the varying Ag content in the layers. The background shows the surface morphology of different AgxCu1–xI layers, illustrating the transition from closed layers to isolated crystals with increasing Ag content.
Realization of Third-Order OAM Mode Using Ring Patch Antenna (2020)

Using single structure antennas to generate electromagnetic waves with orbital angular momentum (OAM) modes can greatly simplify the OAM application systems. However, at present, there is a lack of theoretical guidance for the realization of OAM modes using only a single antenna. In this communication, the characteristic mode theory (CMT) is applied to analyze the current wavemodes of the patch antenna. Then, the orthogonal degenerate modes are selected and the feeding structure is determined to obtain the desired OAM mode. For example, a third-order OAM radio wave is implemented by a ring patch antenna, and the performance of this OAM mode is explained by using the modal excitation coefficient. It is verified that the CMT is an effective analysis tool for a single antenna to achieve OAM modes.
Collocation methods for multi-vehicle trajectory optimization (2013)

Direct collocation offers an efficient way of transcribing optimal control problems to form nonlinear optimizations. Collocation is particularly attractive for variable time problems as the finishing time can be made a decision variable. However, this causes problems in coupled multivehicle problems, for example, where different vehicles may have different finishing times. This paper proposes a way of capturing coupling constraints - in particular, collision avoidance - between vehicles without requiring a common time of arrival. The approach exploits a recently-developed dualization approach for avoidance constraints, extended to act time as well as spatial dimensions.