gebhart/patrepeval huggingface dataset:
Synthèse de RNA stables dans une souche d'Escherichia coli stringent pendant la carence en acide aminé spécifique (1970)

By definition amino‐acid starvation of an RC str Escherichia coli strain causes simultaneous arrest of RNA and protein synthesis. However, it has recently been demonstrated that under such conditions mRNA synthesis does not stop and this result showed that RNA synthesis is not a coordinated process. The present study, which was carried out to determine the effects of amino‐acid starvation on net RNA synthesis in an RC str E. coli strain, has led to the following results: a) during amino‐acid starvation net RNA synthesis is reduced to about 5% of the normal level; b) ribosomal RNA appears in 50 S and 30 S ribosomes and in 38 S and 21 S particles which seem to be precursors of 50 S and 30 S ribosomes, respectively; c) analysis by chromatography on methylated albumin column and by electrophoresis on polyacrylamide gels shows that the 38 S particle is devoid of 5 S RNA; d) a 5 S RNA appears in the supernatant fraction of ribosome preparations. This RNA, which is slightly different from the true 5 S RNA, is called 5 S stringent RNA. With respect to its chromatographic behaviour on G‐100 Sephadex and methylated albumin column, its mobility on disc electrophoresis, it is identical to 5 S relax RNA and 5 S chloromycetin RNA which are synthesized when protein synthesis is blocked either by amino‐acid starvation of a RC rel E. coli strain or by addition of chloromycetin; e) from the relative quantity of the different classes of RNA it is concluded that RNA synthesis is not coordinated and from the appearance of rRNA in ribosomal particles, a mechanism concerning the regulation of RNA synthesis is proposed.
Immobilization of Trypsin on Graphene Oxide Nanosheets for Increased Proteolytic Stability (2012)

Abstract To increase the thermal and chemical stabilities of trypsin-proteolysis activity, trypsin was immobilized on graphene oxide nanosheets (GONSs) by a one-step diimide-activated amidation. The trypsin-immobilized GONS (1.9 mg per mg-GONS) showed significantly higher thermal and chemical stabilities than the free form. After heat treatment at 50 °C for 6 h, the trypsin–GONS retained 80% of its initial activity, but free trypsin retained only 4% of its initial activity.
In Situ Grafting Made Easy (1988)

In situ bypass grafting has come of age following a period of disenchantment. It has become, in some centers, the operation of choice for bypasses to the tibial and peroneal vessels. Two fundamentally different techniques for this procedure have evolved. The first, following the method of Hall, uses a retrograde valvulotome passed from the distal saphenous vein to the proximal vein; on withdrawal, it severs the valves. A second approach, that of Leather, uses microscissors and a right-angle valvulotome, along with a disposable valve stripper, to disrupt the valves. Proponents exist for both approaches. In 1983 we reported our protocol for in situ grafting using the Hall technique. A number of modifications have since been made to expedite the technique. We describe and provide illustrations of these modifications.
A BDD-based fast heuristic algorithm for disjoint decomposition (2003)

This paper presents a heuristic algorithm for disjoint decomposition of a Boolean function based on its ROBDD representation. Two distinct features make the algorithm feasible for large functions. First, for an n-variable function, it checks only O(n2) candidates for decomposition out of O(2n) possible ones. A special strategy for selecting candidates makes it likely that all other decompositions are encoded in the selected ones. Second, the decompositions for the approved candidates are computed using a novel IntervalCut algorithm. This algorithm does not require re-ordering of ROBDD. The combination of both techniques allows us to decompose the functions of size beyond that possible with the exact algorithms. The experimental results on 582 benchmark functions show that the presented heuristic finds 95% of all decompositions on average. For 526 of those functions, it finds 100% of the decompositions.
S0830 The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study (2020)

INTRODUCTION: There are limited data on how vedolizumab (VDZ) impacts extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD). We aimed to determine the outcomes of pre-existing EIMs after initiation of VDZ. METHODS: A multicenter retrospective study of IBD patients with pre-existing EIMs who received at least 1 dose of VDZ between January 1, 2014 and August 1, 2019 was conducted. EIMs included: peripheral arthritis (PA), uveitis, episcleritis, erythema nodosum (EN), pyoderma gangrenosum (PG), stomatitis, sacroiliitis (SI), and ankylosing spondylitis (AS). The primary outcome was the rate of worsening EIMs after VDZ. We assessed factors associated with worsening EIMs, and compared arthritis EIMs (combined PA, SI and AS) to non-arthritis-EIMs after VDZ. RESULTS: A total of 201 IBD patients with EIMs prior to VDZ (median age 38.4 years (IQR, 29–52.4); 62.2% female; 72.6% Crohn’s disease) were included. VDZ was dosed every 6–8 weeks in 59.7% of patients and 66 (32.8%) received combination therapy with immunomodulator. The most common type of EIM prior to VDZ was PA (68.2%), followed by EN/PG (18.9%), SI (15.4%); AS (14.4%); stomatitis (13.9%); and episcleritis/uveitis (12.9%). Worsening of EIMs after VDZ occurred in 34.8% (Table 1). Exacerbations of EIMs occurred more frequently after 3 months of VDZ initiation (58.6%). Patients with worsening of EIM after VDZ were more commonly dosed every 6–8 weeks vs. every 4 weeks (70% vs 45.8%, P = 0.03). There was no significant difference between those with worsened EIM (n = 70) and stable EIM (n = 131) in terms of age, IBD type, concomitant immunosuppressive therapy or IBD disease activity parameters (Table 1). PA was significantly more common in the worsening EIM group (84.3% vs 59.6%, P = 0.0004). Among the 157 patients with arthritis-EIMs combined, 64 (40.8%) demonstrated worsening after VDZ, which was significantly higher compared to 6 (13.6%) among the 44 with non-arthritis-EIM (Figure 1). Worsening of EIM was associated with higher rate of discontinuation of VDZ during study follow-up when compared to the stable EIM group (61.4% vs. 44%, P = 0.02). VDZ was discontinued specifically due to worsening EIM in 9.5%. CONCLUSION: EIM worsening rate after VDZ was 34.8%, more commonly due to arthritis (40.8%) vs. non-arthritis (13.6%) EIMs. Concomitant immunosuppressive therapy, corticosteroids or IBD disease activity did not predict the course of EIMs after VDZ. VDZ had to be discontinued in almost 10% due to worsening EIMs.Table 1.: Characteristics of Patients with Worse and Stable EIM after VedolizumabFigure 1.: Arthritis Extra-intestinal manifestations following Vedolizumab Use (n = 201).
Figure S6 from Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy (2023)

&lt;p&gt;SUPPLEMENTARY FIG. S6. Signaling pathways activated in SK-OV-3MISRII donor cells exposed to 213Bi-anti-MISRII mAb + filipin and in recipient cells.&lt;/p&gt;
On the Access Pricing and Network Scaling Issues of Wireless Mesh Networks (2007)

Distributed wireless mesh network technology is ready for public deployment in the near future. However, without an incentive system, one should not assume that private self-interested wireless nodes would participate in such a public network and cooperate in the packet forwarding service. This paper studies the use of pricing as an incentive mechanism for stimulating participation and collaboration in public wireless mesh networks. Our focus is on the "economic behavior" of the network nodes-the pricing and purchasing strategies of the access point, wireless relaying nodes, and clients. We use a "game-theoretic approach" to analyze their interactions from one-hop to multihop networks and when the network has an unlimited or limited channel capacity. The important results that we show are that the access point and relaying wireless nodes will adopt a simple yet optimal fixed-rate pricing strategy in a multihop network with an unlimited capacity. However, the access price grows quickly with the hop distance between a client and the access point, which may limit the "scalability" of the wireless mesh network. In case where the network has limited capacity, the optimal strategy for the access point is to vary the access charge and even interrupt service to connecting clients. To this end, we focus on the access point adopting a non-self-enforcing but more practical "fixed-rate noninterrupted service" model and propose an algorithm based on the Markovian decision theory to devise the optimal pricing strategy. Results show that the scalability of a network with limited capacity is upper bounded by one with an unlimited capacity. We believe that this work will shed light on the deployment and pricing issues of distributed public wireless mesh networks.
Left Ventricular Dilatation and Posterior Papillary Muscle Displacement in an Ex Vivo Pulsatile Model of Functional Mitral Regurgitation (2018)

The large patch ex vivo pulsatile heart model demonstrated outward displacement of the PPM and significantly produced MR flow. This ex vivo pulsatile heart model can be used to facilitate surgical techniques that targets the PPM displacement in FMR patients.
Three voting protocols: ThreeBallot, VAV, and twin (2007)

We present three new paper-based voting methods with interesting security properties. Our goal is to achieve the same security properties as recently proposed cryptographic voting protocols, but using only paper ballots and no cryptography. From a security viewpoint we get reasonably close, particularly for short ballots. However, our proposals should probably be considered as more “academic ” than “practical.” In these proposals, not only can each voter verify that her vote is recorded as intended, but she gets a “receipt ” she can take home that can be used later to verify that her vote is actually included in the final tally. But her receipt does not allow her to prove to anyone else how she voted. All ballots cast are scanned and published in plaintext on a “public bulletin board ” (web site), so anyone may correctly compute the election result. In ThreeBallot, each voter casts three paper ballots, with certain restrictions on how they may be filled out. These paper ballots are of course “voterverifiable.” A voter receives a copy of one of her ballots as her “receipt”, which she may take home. Only the voter knows which ballot she copied for her receipt. The voter is unable to use her receipt to prove how she voted or to sell her vote, as the receipt doesn’t reveal how she voted. A voter can check that the web site contains a ballot matching her receipt. Deletion or modification of ballots is thus detectable; so the integrity of the election is verifiable. VAV is like ThreeBallot, except that the ballotmarking rules are different: one ballot may “cancel” another (VAV = Vote/Anti-Vote/Vote). VAV is better suited to – i.e. yields better security properties The latest version of this paper is always at
ChemInform Abstract: Efficient Syntheses of Acromelic Acid B and E, Which are Potent Neuroexcitatory Amino Acids. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chronic lymphocytic leukemia with prostate infiltration mediated by specific clonal membrane-bound IgM. (2003)

Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of monoclonal B lymphocytes in the hematopoietic organs. Rarely, CLL cells accumulate in a single atypical site. The mechanism underlying this unusual distribution of CLL cells has not been studied previously. We obtained peripheral blood from five patients having early stage CLL with heavy prostate infiltration. These patients' circulating CLL cells bound strongly in vitro to cultured prostate cell lines PC3, LNCaP, and DU145 and to short-term cultures of fresh prostate cells but not to colon, breast, or bladder cells. CLL cells from patients without prostate infiltration did not bind in vitro to any cell line. Peripheral blood CLL cells from one patient with CLL with heavy prostate infiltration were fused with a mouse-human heteromyeloma line to make hybridomas expressing the same monoclonal IgM as the patient's CLL cells. The hybridoma cells bound specifically to prostate cells. IgM secreted by the hybridoma blocked binding of the patient's CLL cells to prostate cells. Flow cytometry and immunohistochemistry demonstrated that the secreted IgM bound specifically to prostate cells. These results indicate that CLL with atypical prostate infiltration can be mediated by specific surface-bound IgM against an antigen expressed specifically by prostate cells and suggest that a similar mechanism might also apply to cases of CLL with atypical infiltration into other organs.
<title>Trade-offs for quenched avalanche photodiode (QAPD) sensors for imaging turbid media</title> (1999)

We evaluate the efficiency of a new optoelectronic quenched avalanche sensor, with the potential of enabling high resolution imagin through turbid media with femtosecond lasers. Our target application is for imaging cancer in the human breast.
Edge-Based Color Constancy (2007)

Color constancy is the ability to measure colors of objects independent of the color of the light source. A well-known color constancy method is based on the gray-world assumption which assumes that the average reflectance of surfaces in the world is achromatic. In this paper, we propose a new hypothesis for color constancy namely the gray-edge hypothesis, which assumes that the average edge difference in a scene is achromatic. Based on this hypothesis, we propose an algorithm for color constancy. Contrary to existing color constancy algorithms, which are computed from the zero-order structure of images, our method is based on the derivative structure of images. Furthermore, we propose a framework which unifies a variety of known (gray-world, max-RGB, Minkowski norm) and the newly proposed gray-edge and higher order gray-edge algorithms. The quality of the various instantiations of the framework is tested and compared to the state-of-the-art color constancy methods on two large data sets of images recording objects under a large number of different light sources. The experiments show that the proposed color constancy algorithms obtain comparable results as the state-of-the-art color constancy methods with the merit of being computationally more efficient.
Thermodynamic study of Fe-Ta and Fe-Nb alloys by means of the Knudsen cell mass spectrometry. (1989)

The activity of iron in the Fe–Ta and Fe–Nb alloys at 1 873 K was determined by means of the Knudsen cell mass spectrometry. A modified internal standard method was employed, in which a piece of pure iron foil placed on the sample surface in the Knudsen cell served as the internal standard material. The ion intensity of iron from the foil was first measured at several temperatures before the alloy sample and the foil melted together. The ion intensity from pure solid iron thus obtained was extrapolated to give ion intensity from pure liquid iron at higher temperatures. The temperature of the sample was then raised to form uniform liquid alloy and the ion intensity of iron from the alloy was measured. The activity of iron in the alloy was determined by comparing the ion intensities from pure iron and from alloy.The activities of Ta and Nb were derived from that of iron by integrating the Gibbs-Duhem equation. The activity coefficients of Ta and Nb in the infinitely dilute solution with liquid pure metal as the standard state were also calculated. The interaction parameters were determined. These results were compared with those of elements adjacent to Ta and Nb in the periodic table.Invariant reactions appeared in the Fe–Ta binary alloy system at high temperature were investigated by employing the ion intensity thermal analysis, in which the ion intensity represented the temperature of the sample. Heat treatment and metallographic study was also carried out for the identification and composition determination of phases.
Discovery and properties of a new indigoid structure type based on dimeric cis-indigos (2020)

Reactions of indigo with quinones in the presence of sodium hydride leads unexpectedly to products containing two indigo subunits; one indigo is featured in a cis configuration and fused via its indole nitrogen atoms to a second indigo at the central C-C bond of the latter. Structural, optical, and redox properties of the new compounds are reported.
MODELING COOPERATION IN VIRTUAL DISTRICTS: A METHODOLOGY FOR E-SERVICE DESIGN (2004)

E-services can be used to wrap an organization's information system and to provide a standard interface that enables cooperation with other information systems. As a consequence, e-services should not only support operating activities, but also embed mechanisms for inter-organizational coordination and control over operating activities. Inter-organizational coordination and control are based on contractual agreements that coordinate processes across cooperating companies and establish mechanisms to control the fulfillment of production goals. The objective of this paper is to describe a methodological approach for the design of e-services that supports the specification of inter-organizational coordination and control requirements. The paper explains how the methodology is structured in three phases, from requirements specification to conceptual design and implementation. The first phase of the methodology supports the specification of cooperation requirements, which constitute the static description of coordination and control requirements. In the second methodological phase, this static description is completed with a dynamic description of the actions to be taken upon exceptions, which occur when cooperating partners do not comply with cooperation goals. The static and dynamic description of coordination and control represent a conceptual specification of a business transaction. In the final methodological phase, this conceptual specification is implemented based on the WSDL and BPEL4WS languages for e-service design. The methodology is tested on the case study of the Italian production district of Matera.
Organization and primary sequence of multiple genes encoding type II mRNA species of rice prepro-glutelin. (1989)

We have isolated four independent genomic DNA fragments encoding a rice storage protein, glutelin, by using its cDNA as a probe. Restriction mapping and sequencing analyses showed that all four clones encode type II mRNA of glutelin and have very similar nucleotide sequences. However, several differences were found among the four clones with respect to the nucleotide sequences of their coding and S'-upstream regions, some of which confirmed corresponding changes in the amino acid sequences of the encoded proteins. These results indicate that the genes encoding type II mRNA species of glutelin constitute a multi-gene family of closely related members.
CR-39 polymer, a promising new solid state track recorder for high energy neutron applications (1980)

CR-39 Polymer, a new solid state track recorder with unprecedented sensitivity to lightly ionizing particles (such as protons) is being developed for eventual neutron dosimetry applications in the Fusion Materials Irradiation Test Facility and elsewhere. The diameters of proton tracks have been found to vary smoothly and reproducibly as a function of energy from 0.20 to 18.0 MeV. Preliminary results on the response of CR-39 polymer to proton tracks as a function of angle show a rapid decrease of the registration efficiency from 100% to 0 for angles of incidence less than 75/sup 0/. Proton recoil track size distributions in CR-39 polymer irradiated with monoenergetic neutrons of varying energy are presented. Some proposed high energy neutron dosimetry and radiography systems using CR-39 polymer are discussed.
Purely Relational FLWORs. (2005)

We report on a compilation procedure that derives relational algebra plans from arbitrarily nested XQuery FLWOR blocks. While recent research was able to develop relational encodings of trees which may turn RDBMSs into highly efficient XPath and XML Schema processors, here we describe relational encodings of nested iteration, variables, and the item sequences to which variables are bound. The developed techniques are purely relational in more than one sense: (a) we rely on a standard (or rather: classical) algebra that is readily supported by relational engines, and (b) we use relational concepts like functional and multivalued dependencies to significantly simplify the emitted plans. This work blends well with the mentioned tree encodings and thus contributes a further important building block to investigations into XQuery processors based on relational database technology.
A PERSONAL ACCOUNT OF DEVELOPING THE STERILE INSECT TECHNIQUE TO ERADICATE THE SCREWWORM FROM CURACAO, FLORIDA AND THE SOUTHEASTERN UNITED STATES (2002)

The history is recounted of developing the sterile insect technique to eradicate the screwworm, Cochliomyia hominivorax (Coquerel), from the Caribbean island of Curacao, Florida and the southeastern U.S. Observations of screwworm biology and challenges faced in conducting these eradication projects are described by the author who worked on all aspects of the research and field operations. Eradication was first demonstrated on Curacao, essentially a 170 mi2 outdoor laboratory. The population dynamics of the wild screwworm was determined and overflooding ratios and dispersal patterns essential for population suppression were defined. Eradication was achieved with minimal resources by attacking the pest during the time of year when it is least abundant. In Florida, eradication was greatly facilitated by an unusually cold winter that reduce the range and density of the target population. Eradication could not be attained easily by only suppressing the reproduction of adult screwworms. The larval population also had to be reduced to increase the ratio of sterile to wild males. It was essential to control the immature stages by diligent inspection and treatment of animal wounds. Leadership of the cattle producers was critical not only for securing program resources from the clientele, state legislatures and U.S. Congress, but also for gaining the cooperation of virtually all livestock owners. Additionally, leadership was required to acquire adequate research, extension and public information resources. Lessons learned from this work were corroborated repeatedly as the screwworm eradication program moved into the Southwest, Mexico and the Central America.
Generating text from compressed input (1992)

article Free AccessGenerating text from compressed input: an intelligent interface for people with severe motor impairments Authors: Patrick W. Demasco Univ. of Delaware, Newark Univ. of Delaware, NewarkView Profile , Kathleen F. McCoy Univ. of Delaware, Newark Univ. of Delaware, NewarkView Profile Authors Info & Claims Communications of the ACMVolume 35Issue 5May 1992 pp 68–78https://doi.org/10.1145/129875.129881Published:01 May 1992Publication History 64citation735DownloadsMetricsTotal Citations64Total Downloads735Last 12 Months49Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF