gebhart/patrepeval huggingface dataset:
The influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes (2008)

Bulk, surface and bioactivity of newly synthesized hydroxy telechelic polyisoprene-based (H-HTPI) polyurethane were investigated by means of ATR-FT-IR, contact-angle measurements, cell viability, calcification, and platelet and fibrinogen quantification. The influence of isophorone diisocyanates isocyanurate (I-IPDI) content on these properties was determined. Results generally showed a non-significant difference in these properties when they were compared with a commercially available biomedical polyurethane (PU), such as Tecoflex. Unexpectedly, where the increase of isocyanate content for commercial diisocyanate-based biocompatible PU significantly increases the surface contact angle, the new hydroxy telechelic polyisoprene-based PU showed a decrease of water contact angle with increasing I-IPDI content in the polymer. Nevertheless, the overall surface exhibited hydrophobic properties, i.e., theta > 85. Polymer cytotoxicity, assessed with L929 cell line in direct contact with the surface of the samples, showed no toxic effects on the cells. Interestingly, regardless of the I-IPDI content, platelet adhesion and fibrinogen adsorption, as well as the mineral deposition were fairly similar for all synthesized PUs. Our findings revealed that replacing diisocyanates by their isocyanurate homologues is a very relevant approach for preparation of polyurethanes with different mechanical properties while maintaining similar surface properties.
Critical evaluation of the JDO API for the persistence and portability requirements of complex biological databases (2005)

The SigPath JDO benchmark and our discussion of JDO technology in the context of biological databases will be useful to bioinformaticians who design new complex biological databases and aim to create systems that can be ported easily to a variety of database backends.
A comparison between automated generated code tools using model based development (2011)

The use of automated generated code tools has been increasing in the last years mainly because it helps engineers to faster and better develop documented software in comparison with hand coded development. Nowadays, there are many tools available from different vendors. However, the most used tools for critical environments and real-time applications are the Rational Rose Real Time (RRRT) and the Rational Rhapsody. Recently, National Instruments, the LabVIEW software vendor, has released a toolkit to develop C code from its visual programming language. This represented a breakthrough for LabVIEW developers, allowing verification of what is being properly developed. Mathworks, the Matlab software vendor, has provided a similar toolkit to the LabVIEW. A case study comparing source codes generated by CASE Tools with hand coded was presented at the ITNG 2008 Conference. In this case study, authors have concluded that hand-made source code is less complex than CASE tools source codes. However, the cost/benefit becomes better when using CASE tools. The main purpose of this paper is to provide an insight about automated generated code using Model Based Development (MBD) tools (LabVIEW, Matlab, and Rational Rose Real Time). The case study presents the modeling of a 100 points sine wave application. A comparison between code metrics is performed, in order to verify which tool best fits into your project.
Corrigenda (1979)

W. H. Kruizinga, R. M. Kellogg, C. J. Marsden, R. D. Brown, P. D. Godfrey, H. K. L. Hundt, D. G. Roux, J. J. Botha and D. Ferreira, J. Chem. Soc., Chem. Commun., 1979, 727 DOI: 10.1039/C39790000727
Vaginal Apical Pain After Sacrocolpopexy in Absence of Vaginal Mesh Erosion (2015)

The development of de novo pain in the absence of mesh erosion after sacrocolpopexy is an uncommon event but in our cases required complete excision for relief of symptoms. Further research will be needed to understand if surgical technique or materials may be related to the development of symptoms.
A Low-Power Low-Noise Single-Chip Receiver Front-End for Automotive Radar at 77 GHz in Silicon-Germanium Bipolar Technology (2007)

This paper presents a single chip receiver front-end, including low-noise amplifier and mixer, for application in automotive radar systems at 77GHz. The circuit has been implemented in a SiGe HBT technology. The complete circuit occupies 1030 × 1130 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μm<sup>2</sup></i> including bond pads and dissipates 440mW from a 5.5V supply. The front-end shows a minimum measured single sideband noise figure (SSB NF) of 11.5dB and a maximum conversion gain of 30dB at 77GHz. Linearity measurements show a 1dB input compression point of -26dBm and a third order intercept point of -21.6dBm at 77GHz.
Analysis of Drone assisted Network Coded Cooperation for Next Generation Wireless Network (2019)

In this paper, use of drone as a relay node in Network Coded Cooperation (NCC) for upcoming wireless networks is proposed to achieve additional diversity as well as improve throughput. Unlike static relay cases, in drone assisted scenarios, better performance can be achieved simply by changing the position of relay. In order to quantify the network performance in drone assisted NCC, analytical closed form expression of outage probability has been calculated using two approaches namely, Analytical and Semi-analytical. Using a generalized system model, Probability Density Function (PDF) of Signal to Noise Ratio (SNR) of the path from source to destination via drone (relay) is derived. Closed form expression for outage probability in absence of direct link is also investigated. By analyzing Analog Network Coding (ANC) noise, statistical parameters of variance of ANC-noise have been obtained. Analytical findings have been verified through extensive simulations using MATLAB. Effects of drone height on system performance is also investigated through simulations. Framework presented here can be useful while analysing networks having resource constraint devices. PDF of SNR of relay path can be utilized for performing diversity calculations. Two outage expressions derived may be useful in determining system parameters for achieving any particular Quality of Service (QoS) in next generation wireless networks. Valuable insights obtained through the analysis of optimum height of drone are conducive while deploying the nodes in deterministic fashion for NCC.
Release of interlayer potassium in Norwegian grassland soils (2005)

Abstract Potassium (K) release from sources that are not initially exchangeable is attributed to depletion of interlayer K of micas and clay minerals or weathering of feldspars. The aim of the present study was to estimate the K release from interlayer K. Soil samples from 17 field experiments in ley on a range of mineral soils in Norway were used in the study. The change in K‐fixation capacity was used as an estimate of depletion of interlayer K. It was assumed that the increase in K‐fixation capacity during 3 yr of cropping was equivalent to the amount of K depleted from the interlayer positions. Mean K fixation increased in the majority of the soils during 3 yr of grass cropping both with and without K application. The increase in K fixation indicated that without K application, the K uptake from interlayer K amounted to 43%, 28%, and 26% of the K yield for clay soils, high‐K sandy soils, and low‐K sandy soils, respectively. Including K uptake from exchangeable K in the topsoil and from subsoil, the explained K uptake amounted to 79%, 69%, and 81% for the three groups of soil, respectively. Simple linear‐regression analyses showed that the change in K fixation during 3 yr of grass cropping was best explained by the percentage of clay in the soil.
An Architecture for Spatial Audio Servers (1993)

Before spatial sound can be useful in large software systems, there must be a sufficient application programmer's interface (API) for the control of the spatial audio system and for the management of finite audio processing resources. Researchers are using virtual environments as driving applications to determine the requirements of such an interface.
Lytic Phage-Based Magnetoelastic Biosensors for On-site Detection of Methicillin-ResistantStaphylococcus aureuson Spinach Leaves (2015)

A lytic phage-based magnetoelastic (ME) biosensor method was firstly employed for on-site detection of methicillin-resistant Staphylococcus aureus (MRSA) on spinach leaves. Due to the virulent activity of this lytic phage, the effect of time and temperature on the extent of MRSA lysis was examined by incubating a mixture of the MRSA and lytic phage at various times (0, 15, 30, 45, 60, 75, and 90 min) and temperatures (0, 4, 15, 22, 37, and 45°C). After optimization of incubation time and temperature, spinach leaves were spiked with serial concentration of MRSA and the attachment of MRSA was confirmed using SEM. The phage-immobilized sensor and control (devoid of the lytic phage) sensor were placed on the surface of the leaves and the resonant frequency shifts of both sensors were compared. The optimal incubation time and temperature for contact of the phage-immobilized ME biosensor with the MRSA were determined to be ≤ 30 min and ≤ 22°C. The attachment of the lytic phage on the sensor was observed and the density of lytic phage on the sensor was determined to be 26 ± 3 particles/μm2. The resonant frequency shifts of the phage-immobilized sensor linearly increased with the increase in the MRSA concentration and had a correlation coefficient and slope of 0.819 and 840.9 Hz/log CFU, respectively. Detection limit was determined to be 1.76 log CFU/25 mm2 surface of spinach.
Noninvasive Separation of Large, Medium, and Small Myocardial Infarcts in Survivors of Reperfused ST-Elevation Myocardial Infarction (2008)

Circumferential and longitudinal strains by 2D-STE correlate with myocardial infarct mass and significantly differentiate among large, medium, and small myocardial infarcts.
Use of substituted benzyl esters as carboxyl-protecting groups in solid-phase peptide synthesis (1976)

The effect of confinement on the coalescence of Newtonian (polydimethylsiloxane) droplets in a Newtonian (polyisobutylene) matrix is investigated experimentally. A counter rotating parallel plate device, equipped with a microscopy setup, is used to visualize two interacting droplets during shear flow. The ratio of droplet-to-matrix viscosity is kept constant at 1.1. Droplet collisions are studied for a range of droplet sizes, both in bulk conditions and for gap spacings that are comparable to the droplet size. As a result, we present the first quantitative experimental data set for the coalescence of two equal-sized droplets in a pure shear flow with varying degrees of confinement. Compared to bulk conditions, for droplets smaller than roughly 0.2 times the gap spacing, a slight degree of confinement only decreases the orientation angle at which the droplets coalesce whereas the critical conditions for coalescence remain unaltered. For more confined conditions, the critical capillary number up to which coalescence can occur, increases. Therefore, confinement clearly promotes coalescence. In addition, the droplet trajectories, the time-dependent orientation angle of the droplet pair, and the droplet deformation prior to the coalescence event are systematically studied, and a comparison between the confined and the unconfined situation is provided. It is shown that the presence of two parallel walls can induce changes in the flow field around the droplet pair, which cause an increase of the interaction time between the droplets. Moreover, for sufficiently confined droplets, the additional force originating from the presence of the walls becomes comparable to the hydrodynamic force on the droplet pair, thus influencing the drainage of the matrix film between the droplet surfaces
Hemodynamics and metabolism of the in vivo vascularly isolated canine pancreas. (1979)

Surgical procedures are detailed that have yielded for the first time an in vivo vascularly isolated, autoperfused preparation of the entire pancreas in anesthetized dogs. Previous studies had isolated only part of the pancreas or had resorted to blood-flow techniques not requiring pooled pancreatic venous blood, necessary for metabolic studies of the organ. Pancreatic blood flow (48 ml/min), O2 uptake (180 mumol/min), glucose uptake (51.0 mumol/min), lactate output (6.6 mumol/min), net free fatty acid uptake (2.23 mumol/min), all per 100 g tissue, and various other measured and calculated hemodynamic and metabolic variables were determined on the preparation during control conditions. The stability of the preparation was verified by serial determinations of these parameters and of blood alpha-amylase and beta-glucuronidase levels from 1 to 2.5 h postsurgery. Metabolic rate and glucose uptake were both found to be much higher than in intestinal tissues and approached values characteristic of liver tissue.
Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells (2023)

Prostate cancer (PCa) is the second most prevalent malignancy in males across the world. A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa. Herein, we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients, including gene mutations, mRNA/protein/surface protein distributions, and pharmaceutical responses. The multi-omics analyses identify Anterior Gradient 2 (AGR2) as a pre-operative prognostic biomarker in PCa. Through the drug library screening, we describe crizotinib as a selective compound for malignant PCa primary cells. We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations. Surprisingly, the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model. Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses, allowing for more precise diagnosis and therapies.
Supplementary Table from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer (2023)

Supplementary Table from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
Co3O4 Nanoparticles with Multi-Enzyme Activities and Their Application in Immunohistochemical Assay (2014)

Co3O4 nanoparticles (Co3O4 NPs), synthesized by the coprecipitation method, showed intrinsic catalase-like, peroxidase-like, and SOD-like activity. The catalytic activity of Co3O4 NPs was much higher than analogous Fe3O4 NPs. Co3O4's mechanisms of catalytic activity were analyzed in detail using the electron spin resonance (ESR) method, which confirmed that Co3O4 NPs don't follow the classical Fenton reactions with hydrogen peroxide the way Fe3O4 NPs do. The high redox potential of Co(3+)/Co(2+) was supposed to be the leading cause of the differences in both activity and mechanism with Fe3O4. Based on the high, peroxidase-like activity, a new immunohistochemical assay was designed in which the avastin antibody was conjugated onto the surface of Co3O4 NPs. The conjugates obtained were used to detect vascular endothelial growth factor (VEGF) that was overexpressed in tumor tissue. When the experimental and control groups were stained, there were clear distinctions between them. This study showed that there are many opportunities to improve the enzyme-like activities of nanomaterials and also to improve their potential applications for biocatalysis and bioassays, especially in relatively harsh conditions.
Catalytic Scaffolding Ligands: An Efficient Strategy for Directing Reactions (2008)

The design and application of a scaffolding ligand that promotes branch and diastereoselective hydroformylation of terminal olefins as well as the regio- and diastereoselective hydroformylation of disubstituted olefins is reported. It is shown that the ligand covalently and reversibly bonds to the substrate, allowing for directed hydroformylation. As the substrate ligand interaction is dynamic, hydroformylations are catalytic in ligand and do not require any additional synthetic steps to add or remove the directing group. Using a catalytic quantity of a scaffolding ligand (20-25 mol %), excellent regioselectivity for disubstituted olefins (up to 98:2) and high branch selectivity (up to 88:12) for terminal olefins were obtained.
Lysolecithinase of Rat Brain (1974)

Abstract The inhibition of lysolecithinase by its substrate is further analyzed. A considerable portion of lysolecithin was adsorbed onto particulate or microsomal preparations of rat brain. The adsorbed substrate could be desorbed by isotonic sucrose and, to a greater extent, by serum albumin. The degree of adsorption depended on the quantity of protein and the concentration of lysolecithin. The V/S curves were biphasic, having an ascending portion, an point, and a descending part. When the reaction rates were related to the unadsorbed, rather than the total concentration of the substrate, the inversion point (the substrate concentration at which the peak of the biphasic V/S curve occurs) coincided with the critical micellar concentration of lysolecithin. This supports the hypothesis of Leibovitz-BenGershon et al. ((1972) J. Biol. Chem. 247, 6840) that the enzyme utilizes molecular solutions of lysolecithin and is inhibited by its micellar aggregates. The substrate also partly inhibited the enzyme at concentrations smaller than the inversion point. Evidence is presented that this is most probably an irreversible inactivation of the enzyme, caused by lysolecithin molecules or micelles which were adsorbed onto the particles or the microsomes. This inhibition could be prevented by premixing the substrate with serum albumin before adding the enzyme.
A triple redundant controller which adopts the time-sharing fault recovery method and its application to a power converter controller (2002)

A novel fault recovery method, in which memory copy from a normal system to a fault detected system is executed in time-sharing fashion, has been implemented in a triple redundant controller. This method reduces data copy bandwidth required for recovery of the fault detected system, and allows non-stop fault recovery with only a little hardware overhead, even when the controller contains multiple processors and operates at a very short operating period. The developed controller contains triplicated processing units, each of which consists of seven 60 MIPS processor boards connected by a 30 MHz 4 byte bus. One processor board contains a bus arbiter, and each of the remaining six processor boards contains three sets of 100 Mbps two-way optical links, which can be utilized for inter-system memory copy as well as for connecting to 10 units. This controller has been applied to a power converter controller, and a 104 microsecond operating period was achieved.
A preliminary study of the influence of water potential on sclerotium germination in Sclerotinia sclerotiorum (1977)

Sclerotia of Sclerotinia sclerotiorum (Lib.) de Bary buried in a heavy clay soil at 15 °C germinated over a range of moisture levels from 15% to 50%. A method of germinating sclerotia held at constant matric water potentials was tested. Sclerotia were placed in soil in bags of a semipermeable membrane; the bags were immersed in solutions of polyethylene glycol 20 000.Germination occurred between 0 and −7.5 bars but not at lower potentials.
Specific Determination and Identification of Cross-Linked Fibrin Degradation Products in Patients Under Thrombolytic Therapy for Myocardial Infarction (1987)

We have demonstrated that the specific determination and identification of plasma FbDP alone is not sufficient to follow the effectiveness of thrombolytic therapy. Some patients who received an intravenous infusion of rt-PA for myocardial infarction had very high plasma FbDP levels, although no recanalization was observed angiographically. Since in many cases the FbDP levels increased after recanalization, it is assumed that rethrombosis may occur during and after t-PA treatment.
Message Framing and Error Control (1965)

Two problems which arise in the transmission of digital data are message framing and error control. A technique has been developed whereby polynomial coding can be used simultaneously for both error detection and message framing. With this technique, encoded data blocks can be transmitted asynchronously without incorporating any special signals or bit patterns for "start-of-message" and "end-of-message" indications. Erroneously received blocks are automatically deleted from the accepted data stream. The standard systems use a special signal for a start-of-message (SOM) indication at the beginning of each block of data, and independently create and detect a specified format (usually based on parity check sums) to determine when errors have occurred in transmission of the data. In order to achieve high reliability it is necessary to use sophisticated techniques and to devote a large number of transmitted digits to each of these functions. By considering these two problems together a technique which provides a solution to both was found. This technique uses fewer bits than would be required by many conventional approaches to framing to get the same reliability. The error-detection capability which is included is so strong that the mean time between undetected errors is usually dependent on equipment reliability rather than on channel error statistics.
A High Swing Low Power CMOS Differential Voltage-Controlled Ring Oscillator (2007)

This paper presents a two-stage CMOS differential voltage-controlled ring oscillator (VCO). The VCO is intended to operate as a frequency synthesizer in a PLL to generate local oscillator frequency (LO) for an acquisition system, providing in-phase/Q-phase outputs. This work proposes a differential VCO design that has a wide operating frequency tuning range with low power consumption, better phase-noise performance and good linearity between the frequency and control voltage. Simulation results verify the theoretical development and address the layout design. The circuit was designed and simulated in 0.18mum IBM CMOS technology
ChemInform Abstract: Water‐Promoted Reactions: Generation of Oxyallyl Intermediates and Their [4 + 3] Cycloadditions with Furan and Cyclopentadiene. Facile Access to Bridged Cycloheptenones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.