gebhart/patrepeval huggingface dataset:
Effect of partially modified retro‐inverso analogues derived from C‐reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages (1997)

1. The ability of three modified tetrapeptides, representing fragments of the C-reactive protein (CRP) sequence and stabilized in the first peptide bond by retro-inverso modification, to affect the secretion of nitric oxide (NO) was studied in macrophages of BALB/c mice. 2. These tetrapeptides, resembling the aminoacid sequence of tuftsin (CRP 1, H-gThr-(R,S)mLys-Pro-Leu-OH, ITF 1192; CRP II, H-gGly-(R, S)mLys-Pro-Arg-OH, ITF 1127; CRP III, H-gThr-(R,S)mLys-Pro-Gln-OH. ITF 1193), were able to induce NO synthesis by peritoneal macrophages in a dose-dependent manner; the most stimulating dose was 1000 ng ml-1 for CRP II and 100 ng ml-1 for CRP I and CRP III. NO synthesis was not strictly dependent on lipopolysaccharide (LPS) activation. 3. The enhanced effect of retro-inverso CRP-related analogues on the expression of iNOS (inducible NO synthase) was confirmed by higher levels of iNOS activity in the cytosol and by the increase in iNOS protein, as evaluated by Western blot analysis, in macrophages stimulated by CPR compared with untreated ones. 4. The production of NO by retro-inverso CRP-peptide analogues was significantly inhibited by dexamethasone (20 microM), NG-monomethyl-L-arginine (L-NMMA) (500 microM) and pyrrolidine dithiocarbamate (PDTC) (100 microM). 5. Retro-inverso CRP-peptide analogues stimulated macrophages to produce high levels of interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha) in the presence of LPS. 6. Retro-inverso CRP-peptide analogues stimulated NO synthesis by the enhancement of endogenously produced IL-1 and TNF-alpha, as the treatment of peritoneal macrophages with LPS in the presence of neutralizing anti-IL-1 and anti-TNF monoclonal antibodies (mAbs) reduced retro-inverso analogue-induced NO secretion. Data indicate a predominant role for IL-1 alpha in the induction of NO secretion by retro-inverso analogues. 7. These results suggest that retro-inverso CRP derived analogues act as costimulators of NO and cytokine synthesis in macrophages. The mechanisms by which they cause iNOS induction appear to be strongly dependent on the activation of nuclear factor-kappa B (NF-kappa B).
Removal of 1,3-Dichloro2-Propanol and 3-Chloro1,2-Propanediol by the Whole Cell System ofPseudomonas putidaDSM 437 (2006)

The removal of 1,3-dichloro-2-propanol (1,3-DCP), 3-chloro-1,2-propanediol (3-CPD) and their mixtures at concentrations up to 1,000 mg . L(-1) by the whole cell system of Pseudomonas putida DSM 437 was investigated. The 1,3-DCP removal rates ranged from 2.36 to 10.55 mg . L(-1) . h(-1); 3-CPD exhibited approximately two times higher removal rates compared to 1,3-DCP for all concentrations tested. Removal of 1,3-DCP and 3-CPD followed first-order kinetics with rate constants of 0.0109 h(-1) and 0.0206 h(-1), respectively. When the whole cell system of P. putida DSM 437 was applied to mixtures of the two halohdrins, complete removal of 1,3-DCP was achieved at 144 h while removal of 3-CPD was completed at times ranging from 72 to 144 h. Time to achieve 50% removal of both halohydrins depends on the initial concentration of each in the mixture. For 1,3-DCP, it ranged from 40.55 h at 200 mg . L(-1) to 53.28 h at 500 mg . L(-1) while the respected values for 3-CPD were 33.39 and 68.91 h.
Effect of electron beam-irradiation on the structure and catalytic performance of Pd nanoparticles supported on Al2O3 and carbon (2006)

The electron-beam irradiation of Pd/Al2O3 and Pd/C increased dispersion of Pd nanoparticles and activity in toluene hydrogenation by a factor of 3–4.
Blood Group A Antigen Is a Coreceptor in Plasmodium falciparum Rosetting (2000)

The malaria parasite Plasmodium falciparum utilizes molecules present on the surface of uninfected red blood cells (RBC) for rosette formation, and a dependency on ABO antigens has been previously shown. In this study, the antirosetting effect of immune sera was related to the blood group of the infected human host. Sera from malaria-immune blood group A (or B) individuals were less prone to disrupt rosettes from clinical isolates of blood group A (or B) patients than to disrupt rosettes from isolates of blood group O patients. All fresh clinical isolates and laboratory strains exhibited distinct ABO blood group preferences, indicating that utilization of blood group antigens is a general feature of P. falciparum rosetting. Soluble A antigen strongly inhibited rosette formation when the parasite was cultivated in A RBC, while inhibition by glycosaminoglycans decreased. Furthermore, a soluble A antigen conjugate bound to the cell surface of parasitized RBC. Selective enzymatic digestion of blood group A antigen from the uninfected RBC surfaces totally abolished the preference of the parasite to form rosettes with these RBC, but rosettes could still form. Altogether, present data suggest an important role for A and B antigens as coreceptors in P. falciparum rosetting.
Demonstration of supercontinuum generation in a long-cavity fiber ring laser (1998)

We demonstrate generation of supercontinuum pulses directly from a passively mode-locked long-cavity fiber ring laser. The laser output exhibited a blueshifted spectrum extending from 1350 to 1550 nm with an average output power greater than 60 mW.
A 1.3μW 0.6V 8.7-ENOB successive approximation ADC in a 0.18μm CMOS (2009)

A 100KS/s, 1.3μW, 8.7-ENOB successive approximation ADC is proposed with a time-domain comparator which uses a highly digital differential VCDL architecture. Without any reference voltage, the capacitor DAC performs a rail-to-rail conversion range. The ADC, implemented in a standard 0.18μm CMOS, shows a FoM of 31fJ/conversion-step with a single supply voltage of 0.6V.
EFFICIENT CLUSTERING WITH FUZZY ANTS (2004)

this paper we show how the combination of the ant-based approach with fuzzy rules leads to an algorithm which is conceptually simpler, more e#cient and more robust than previous approaches
Progressive Degeneration of the Retinal Nerve Fiber Layer in Patients with Multiple Sclerosis (2012)

Progressive axonal loss can be detected in the optic nerve fiber layer of MS patients. Analysis of the RNFL by OCT can be useful for evaluating MS progression and efficacy of treatment as a neuroprotective factor against axonal degeneration.
Exchange tab readback transducer using reactive ion etching to define the trackwidth (2002)

IrMn was used to stabilize the free layer in exchange tab type magnetic recording readback heads. These heads were fabricated using either reactive ion etching (RIE) or argon ion beam etching (IBE) to define the trackwidth. The two processes were used to eliminate the coupling between the exchange tab material (IrMn) and the free layer (NiFe), which creates a sensitive, nonhysteretic, linear, stable free layer. Wafer level test structures were measured during the head build process and results for the RIE and IBE processes are compared. Transmission electron micrographs were taken. Undercutting of the electrodes can be seen on the RIE processed heads. Spin-stand data for the read heads were compared and the RIE processed heads had a larger low frequency amplitude and sensitivity. Micro-track profiles and tack scans were also taken using the RIE processed heads. The increased process latitude that the RIE process has over the IBE process leads to, on average, overall better performing heads.
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells (2023)

<b>Background:</b> The cGAS/STING pathway, part of the innate immune response to foreign DNA, can be activated by cell's own DNA arising from the processing of the genome, including the degradation of nascent DNA at arrested replication forks, which can be upregulated in cancer cells. Recent evidence raises a possibility that the cGAS/STING pathway may also modulate the very processes that trigger it, e.g., DNA damage repair or processing of stalled forks. <b>Methods:</b> We manipulated STING levels in human cells by depleting or re-expressing it, and assessed the effects of STING on replication using microfluidics-assisted replication track analysis, or maRTA, a DNA fiber assay, as well as immuno-precipitation of nascent DNA, or iPOND. We also assessed STING subcellular distribution and its ability to activate. <b>Results:</b> Depletion of STING suppressed and its re-expression in STING-deficient cancer cells upregulated the degradation of nascent DNA at arrested replication forks. Replication fork arrest was accompanied by the STING pathway activation, and a STING mutant that does not activate the pathway failed to upregulate nascent DNA degradation. cGAS was required for STING's effect on degradation, but this requirement could be bypassed by treating cells with a STING agonist. Cells expressing inactive STING had a reduced level of RPA on parental and nascent DNA of arrested forks and a reduced CHK1 activation compared to cells with the wild type STING. STING also affected unperturbed fork progression in a subset of cell lines. STING fractionated to the nuclear fractions enriched for structural components of chromatin and nuclear envelope, and furthermore, it associated with the chromatin of arrested replication forks as well as post-replicative chromatin. <b>Conclusion:</b> Our data highlight STING as a determinant of stalled replication fork integrity, thus revealing a novel connection between the replication stress and innate immune responses.
Clinical Experience with Intravesical Prostaglandin E 2 | A Prospective Study of 36 Patients (1980)

In a prospective study, intravesical prostaglandins were given to 36 patients who had urinary symptoms associated with a poorly functioning detrusor; 67% of these patients were found to be in chronic retention. Using standard urodynamic techniques, 72% showed objective evidence of an immediate improvement in detrusor function and there was prolonged therapeutic benefit in 39%. A prolonged response occurred only in patients who had an intact sacral reflex arc and urodynamic evidence of a pathologically enlarged bladder, and who did not have radiologically demonstrable outflow obstruction. The use of intravesical prostaglandin to stimulate the detrusor was also found to be of value as a urodynamic technique for the investigation of the lower urinary tract.
Reality forge (2016)

Creating digitals assets, especially surface textures is a tedious, and often unintuitive task. We built a fun to use, interactive projection-mapping system that aims to simplify this process.
Fabrication of AlGaN/GaN HFET with a high breakdown voltage of over 1050 V (2006)

We performed an AlGaN/GaN Schottky barrier diode (SBD) with a high breakdown voltage of over 1000V on Si (111) substrate. An AlGaN/GaN heterostructure without any crack was realized on a Si (111) substrate using a metalorganic chemical vapor deposition (MOCVD). We also fabricated an AlGaN/GaN heterojunction field effect transistor (HFET) using an AlGaN/GaN heterostructure on a Si (111) substrate. The fabrication process was the same as SBD. The gate length and width were 2000 nm and 0.4 mm, respectively. The distance of gate and drain was 15000 nm. The off-state breakdown voltage of the HFET was over 1050V
Exploring doxorubicin localization in eluting TiO2 nanotube arrays through fluorescence correlation spectroscopy analysis (2012)

Drug elution properties of TiO(2) nanotube arrays have been largely investigated by means of solely macroscopic observations. Controversial elution performances have been reported so far and a clear comprehension of these phenomena is still missing as a consequence of a lack of molecular investigation methods. Here we propose a way to discern drug elution properties of nanotubes through the evaluation of drug localization by Fluorescence Correlation Spectroscopy (FCS) analysis. We verified this method upon doxorubicin elution from differently loaded TiO(2) nanotubes. Diverse elution profiles were obtained from nanotubes filled by soaking and wet vacuum impregnation methods. Impregnated nanotubes controlled drug diffusion up to thirty days, while soaked samples completed elution in seven days. FCS analysis of doxorubicin motion in loaded nanotubes clarified that more than 90% of drugs dwell preferentially in inter-nanotube spaces in soaked samples due to decorrelation in a 2D fashion, while a 97% fraction of molecules showed 1D mobility ascribable to displacements along the nanotube vertical axis of wet vacuum impregnated nanotubes. The diverse drug localizations inferred from FCS measurements, together with distinct drug-surface interaction strengths resulting from diverse drug filling techniques, could explain the variability in elution kinetics.
Glucoamylase and glucose oxidase preparations and their combined application for conversion of maltose to gluconic acid (1977)

Abstract The kinetic behavior of a system of multiple enzyme in solution has been studied in a variable volume batch reactor at pH 5, controlled dissolved oxygen concentration, and T = 30°C. The enzymes used were glucoamylase ( R. delemar ), glucose oxidase ( A. niger ), and gluconolactonase ( A. niger ), all of which are important commercial biocatalysts, and a disaccharide was employed as the starting substrate. This study includes the basic kinetic properties of individual enzymes and interactions between components of the reaction mixture. Classical Michaelis–Menten single substrate or two substrate kinetic with parameters based on initial rate data predict correctly the batch time course of the sequential reaction network.
Scheduling and resource management techniques for multiprocessors (1990)

and related areas. Application requirements motivated the major research areas, processor scheduling and non-uniform memory management, as these areas contain the most important problems raised by the changing design and use of multiprocessors.
Probabilistic trust models for social and service networks (2011)

Trust is a fundamental basis for interaction in multiagent systems. Probabilistic trust models support an agent estimating trustworthiness of another agent based on prior experience. We extend and enhance an existing probabilistic trust model to (1) enable agents to establish trust relations between each other based on no more than limited experience, and (2) provide approaches for agents to find and choose desired interaction partners based on the trust they place in others. Our approaches are inspired by challenges arising in the context of social networks and service-oriented computing. All our approaches can be integrated into the base trust model seamlessly.
When a truster needs to estimate the trust to place in a trustee with whom the truster has little prior experience, the truster must rely upon intermediary agents to lead it to one or more witnesses who would have direct experience with the trustee. Trust propagation approaches that exploit the imperfectly transitive nature of trust address this very problem. Where trustworthy witnesses can be found, such approaches can be quite effective. We propose a generalized way to propagate trust that accommodates situations where trustworthy witnesses cannot be found through typical propagation. Our approach supports an agent customizing the patterns by which to search for witnesses. The resulting approach is generic in that it can capture existing network-based approaches merely through the introduction of appropriate patterns.
In service-oriented computing, we consider service selection wherein service consumers choose services with desired nonfunctional properties. To do this, a service consumer needs trust-based approaches to analyze its service network, which is composed of the trust relations the consumer builds from its interactions with service providers. Existing service selection approaches either fail to capture the dynamic relationships between services or assume that the environment is fully observable. Besides, they do not emphasize the relationship between a consumer's interests and the utility the consumer draws from a service. We propose two trust models that build trust by accurately punishing or rewarding services in terms of the qualities they offer. Both models are effective despite incomplete observations regarding the services under consideration. We also design a service selection approach, built on our trust models, to enable consumers to select services based on their individual utility functions, which reflect their preferences, and estimate trust to capture the providers’ quality. This approach guides consumers to construct service compositions that satisfy their quality requirements. An extension of this approach with contracts approximates Pareto optimality without the use of a market mechanism.
Total Solar Irradiance Variability: A Review (1996)

Observations of total solar irradiance from space within the last two decaades convinced the skeptics that total irradiance varies over a wide range of periodicities: from minutes to the 11-year solar activity cycle. Analyses based on these space-borne observations have demonstrated that the irradiance variations are directly related to changes at the photosphere and the solar interior.
Cytotoxic and Mutagenic Effects of Cinnamomum cassia Bark-Derived Materials (2004)

The cytotoxic activities of Cinnamomum cassia (Blume) bark-derived materials toward six human HeLa epithelioid cervix, A549 lung, SK-OV-3 ovarian, SK-MEL-2 melanoma, XF-498 central nerve system, and HCT-15 colon tumor cell lines were evaluated by using sulforhodamine B assay and compared to those of the anticancer agents, cisplatin and mitomycin C. The biologically active constituent of the Cinnamomum bark was characterized as trans- cinnamaldehyde by spectroscopic analysis. The cytotoxic activity of cinnamaldehyde against HeLa, SK-MEL-2, and HCT-15 cell lines was comparable to that of cisplatin and mitomycin C. The compound showed lower activity against A549, SK-OV-3, and XF-498 cell lines than the anticancer agents. Eugenol exhibited moderate activity against SK-OV- 3, XF-498, and HCT-15 tumor cells, and trans-cinnamic acid, cinnamyl alcohol, α -pinene, and β-pinene showed little or no activity against model tumor cells. Cinnamaldehyde was not mutagenic against four strains (TA 98, TA 100, TA 1535, and TA 1537) of Salmonella typhimurium (Castel and Chalm). These results indicate at least one pharmacological action of C. cassia.
I. GAS PHASE CHEMISTRY AND PHOTOCHEMISTRY OF CARBON(7)HYDROGEN(7)OXYGEN(+). II. GAS PHASE CHEMISTRY AND PHOTOCHEMISTRY OF IONS GENERATED IN REACTIONS OF ATOMIC METAL IONS WITH NITROALKANES AND ALKYL NITRITES (PHOTODISSOCIATION) (1984)

Gas phase chemistry and photochemistry of organic and inorganic ions have been investigated using ion cyclotron resonance (ICR) and Fourier transform mass spectrometry (FTMS). The techniques employed for determining ion structures include ion-molecule reactions, collision-induced dissociation (CID), and photodissociation. A study of C(,7)H(,7)O('+) ions from a series of compounds yields evidence for five unique structures and demonstrates the utility of FTMS for the elucidation of isomeric species. In addition, photodissociation and CID studies have been performed on the molecular ions of various substituted toluenes. The reactions of a series of late transition metal ions with methyl nitrite have been studied and are found to proceed through a common intermediate. The products resulting from this intermediate are dependent on the metal ion. The reactions of nitromethane with these metal ions have also been investigated, with the dominant reaction pathway observed being a nitro-to-nitrite rearrangement. The reactions of Fe('+), Co('+), Ni('+), and Rh('+) with a series of nitroalkanes are outlined. These ions exhibit a rich and unusual chemistry in their reactions with nitroalkanes. Evidence is presented for a long-lived (>1 ms) reaction intermediate of C-N insertion. The D(Fe('+)-OH) and D(Co('+)-OH) bond energies have been determined by deprotonation reactions and by photodissociation. Reasonable agreement is observed for the two methods with values of D(Fe('+)-OH) = 77 (+OR-) 6 kcal/mol and D(Co('+)-OH) = 71 (+OR-) 6 kcal/mol obtained by proton transfer and D(Fe('+)-OH) = 73 (+OR-) 3 kcal/mol and D(Co('+)-OH) = 71 (+OR-) 3 kcal/mol obtained by photodissociation. Photodissociation is shown to be a relatively simple technique which gives accurate metal ion-ligand bond energies and which may be applied to many inorganic systems. The reactions of FeOH('+) and CoOH('+) with alkanes have been studied and are found to proceed by both C-H and C-C insertion. No evidence is seen for ROH formation at the metal center. The MOH('+) ions appear to be less reactive than the bare metal ions.
Facing the SNR Wall Detection in Full Duplex Cognitive Radio Networks Using a GLRT Multipath-Based Detector (2021)

Recently, with the advances in self-interference cancellation, full-duplex (FD) techniques have become a feasible approach to improve the spectrum usage in new generation wireless systems. In particular, in cognitive radio networks, FD allows a secondary user to simultaneously sense the spectrum and transmit, improving the network efficiency. However, the residual self interference (RSI) arising from an imperfect cancellation, represents a bottleneck for the spectrum sensing performance. This paper analytically demonstrates that RSI represents a colored noise which leads to the SNR Wall phenomenon making the typical OFDM signal detectors no longer robust. To overcome this drawback, we propose a generalized likelihood ratio test detector exploiting the multipath correlation due to the primary user’s (PU) channel. It is proven that the proposed method is not affected by the SNR Wall, hence it is robust w.r.t an imperfect self-interference cancellation. Specifically, best detection performance is achieved when an approximated knowledge of the maximum delay spread of the PU channel is available, otherwise it is shown that a limited performance degradation occurs. Moreover, provided results highlight that our approach outperforms the classical alternatives in different scenarios, including when PU employs a mixed numerology OFDM signal, which characterizes the 5G New Radio waveform.
Quantitative study of signal decay due to magnetic susceptibility interfaces: MRI simulations and experiments (2007)

Characterization of magnetic susceptibility artifacts is required in a wide range of MRI studies. Experiments with a 0.2T magnet and MRI simulations were used to assess the signal decay over echo time at different pixel sizes in the case of air-water interfaces. The specific experimental signal modulation which was reproduced in simulation was interpreted. Concordance between simulation and experiments should make possible further studies of magnetic susceptibility effects with more complex objects as in molecular imaging and in porous medium imaging.