gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of 1,5‐Substituted Tetrazoles from Secondary Thioamides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Centrosome and Centriole Abnormalities During Cancer In the Transgenic Adenocarcinoma Mouse Prostate (Tramp) Model (1999)

Abstract Centrosome abnormalities and abnormal mitotic formations have been shown in human breast cancer tissue and in LNCaP and DU145 prostate cancer cells in culture. Here we report on abnormal centrosome and centriole organization in the transgenic adenocarcinoma mouse prostate (TRAMP) model and on the implications for abnormal cell divisions, genomic instability, and apoptosis. Centrosomes are microtubule organizing centers which assemble bipolar spindles in normal cells. In cancer, centrosomes cause the formation of mono-, tri-, and multipolar mitoses which will separate chromosomes unequally during cell division. We investigated the occurence of abnormal mitoses in TRAMP tissue in different stages of cancer progression using transmission electron microscopy (TEM). Advanced stages of prostate cancer are characterized by multiple abnormal mitoses ranging from tripolar to unusual multipolar formations. In addition, apoptotic bodies are abundant which may indicate that multipolar mitoses will lead to cell death or apoptosis.
Carrier Mobility Variations in Self-Aligned Germanium MOS Transistors (2010)

Abstract not Available.
Advanced Polymeric Nanotechnology to Augment Therapeutic Delivery and Disease Diagnosis (2020)

Therapeutic and diagnostic payloads are usually associated with properties that compromise their efficacy, such as poor aqueous solubility, short half-life, low bioavailability, nonspecific accumulation and diverse side effects. Nanotechnological solutions have emerged to circumvent some of these drawbacks, augmenting therapeutic and/or diagnostic outcomes. Nanotechnology has benefited from the rise in polymer science research for the development of novel nanosystems for therapeutic and diagnostic purposes. Polymers are a widely used class of biomaterials, with a considerable number of regulatory approvals for application in clinics. In addition to their versatility in production and functionalization, several synthetic and natural polymers demonstrate biocompatible properties that dictate their successful biological performance. This article highlights the physicochemical characteristics of a variety of natural and synthetic biocompatible polymers, as well as their role in the manufacture of nanotechnology-based systems, state-of-art applications in disease treatment and diagnosis, and current challenges in finding a way to clinics.
Layered Fibrous Treatments for a Sound Absorption and Sound Transmission (1997)

&lt;div class="htmlview paragraph"&gt;In this paper, experimental evidence will be presented to demonstrate that unstiffened, low density fibrous materials are “limp”: i.e., their &lt;i&gt;in vacuo&lt;/i&gt; bulk stiffness is very small compared to that of air with the result that the materials' solid phase motion becomes acoustically significant. Next, a new limp porous material model is presented. It is shown that this model may be used in conjunction with transfer matrices to predict the absorption or transmission loss of arbitrarily layered combinations of fibrous layers, permeable or impermeable membranes, and air spaces. The predictions of this model agree well with experimental measurements and so may be used to optimize sound absorption or transmission treatments.&lt;/div&gt;
Hayabusa Re-entry: Trajectory Analysis and Observation Mission Design (2011)

On June 13th, 2010, the Hayabusa sample return capsule successfully re-entered Earth s atmosphere over the Woomera Prohibited Area in southern Australia in its quest to return fragments from the asteroid 1998 SF36 Itokawa . The sample return capsule entered at a super-orbital velocity of 12.04 km/sec (inertial), making it the second fastest human-made object to traverse the atmosphere. The NASA DC-8 airborne observatory was utilized as an instrument platform to record the luminous portion of the sample return capsule re-entry (~60 sec) with a variety of on-board spectroscopic imaging instruments. The predicted sample return capsule s entry state information at ~200 km altitude was propagated through the atmosphere to generate aerothermodynamic and trajectory data used for initial observation flight path design and planning. The DC- 8 flight path was designed by considering safety, optimal sample return capsule viewing geometry and aircraft capabilities in concert with key aerothermodynamic events along the predicted trajectory. Subsequent entry state vector updates provided by the Deep Space Network team at NASA s Jet Propulsion Laboratory were analyzed after the planned trajectory correction maneuvers to further refine the DC-8 observation flight path. Primary and alternate observation flight paths were generated during the mission planning phase which required coordination with Australian authorities for pre-mission approval. The final observation flight path was chosen based upon trade-offs between optimal viewing requirements, ground based observer locations (to facilitate post-flight trajectory reconstruction), predicted weather in the Woomera Prohibited Area and constraints imposed by flight path filing deadlines. To facilitate sample return capsule tracking by the instrument operators, a series of two racetrack flight path patterns were performed prior to the observation leg so the instruments could be pointed towards the region in the star background where the sample return capsule was expected to become visible. An overview of the design methodologies and trade-offs used in the Hayabusa re-entry observation campaign are presented.
Effect of prior oxygen exposure on the electroretinographic responses of infant rats. (1995)

The function of the rod photoreceptors, as well as the inner retina, is altered in infant rats with a history of oxygen exposure.
Effect of omega-3 supplementation on neuropathy in type 1 diabetes (2017)

This study provides Class IV evidence that for patients with T1DM and evidence of DSP, 12 months of seal oil omega-3 supplementation increases CNFL.
Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives (2017)

Over the last decades, extensive basic and clinical knowledge has been acquired on the use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease (PD). It is now clear that mechanisms involved in the effects of this therapy are far more complex than previously anticipated. At frequencies commonly used in clinical practice, neural elements may be excited or inhibited and novel dynamic states of equilibrium are reached. Electrode contacts used for chronic DBS in PD are placed near the dorsal border of the nucleus, a highly cellular region. DBS may thus exert its effects by modulating these cells, hyperdirect projections from motor cortical areas, afferent and efferent fibers to the motor STN. Advancements in neuroimaging techniques may allow us to identify these structures optimizing surgical targeting. In this review, we provide an update on mechanisms and the neural elements modulated by STN DBS.
The oxygen effect and therapeutic approaches to tumour hypoxia (2018)

The response of cells to ionizing radiation is strongly dependent upon oxygen. Cell surviving fraction is shown as a function of radiation dose administered either under normal aerated conditions or under hypoxia. The enhancement of radiation damage by oxygen is approximately dose modifying (i.e. the radiation dose that gives a particular level of survival is reduced by the same factor at all levels of survival). This allows us to calculate an oxygen enhancement ratio (OER) for the same level of biological effect. For most cells the maximum OER in culture (comparing doses under 21% air and under anoxia) for X-rays is around 2.5–3. However, some studies suggest that at radiation doses of 3 Gy or less the OER is somewhat reduced. This is an important finding because this is the dose range for clinical fractionation treatments.
Infrasound Array Analysis of Debris Flow Activity and Implication for Early Warning (2019)

Debris flows constitute a severe natural hazard and studies are performed to investigate triggering mechanisms and to identify and evaluate early warning systems. We present a seismoacoustic analysis of debris flow activity at Illgraben, Switzerland, with infrasound data collected with a small aperture array. Events are recorded as emergent signals of long duration, with seismic and infrasound amplitudes scaling with the flow discharge. The spectral content is stable and peaking at 8 Hz for the seismic and at 5 Hz for the infrasound that suggests two separate processes of elastic energy radiation, most likely bed‐load transport for the seismic and waves at the free surface for the infrasound. Although amplitude and frequency content of the infrasound signal are well within the processing limits, most of the signal is not showing any correlation among the array elements. We suggest that this is a consequence of the contribution of multiple sources of infrasound acting with variable amplitude and phase along the surface of the debris flow. At Illgraben, coherent infrasound is recorded only from fixed sources, corresponding to check dams within the channel. Here infrasound radiation is increased and the dams turn into predominant sources of energy. This allows to unambiguously identify the occurrence of debris flow at Illgraben with the infrasound array, from a remote and safe position and with a timing that is similar to the early warning system based on in‐channel sensors. This clearly shows how infrasound arrays could be used as an efficient early warning systems.
Methodology for tDCS integration with fMRI (2019)

Abstract Integration of tDCS with fMRI holds promise for investigation the underlying mechanism of stimulation effect. There are 118 published tDCS studies (up to 1 st Oct 2018) that used fMRI as a proxy measure of neural activation to answer mechanistic, predictive, and localization questions about how brain activity is modulated by tDCS. FMRI can potentially contribute as: a measure of cognitive state-level variance in baseline brain activation before tDCS; inform the design of stimulation montages that aim to target functional networks during specific tasks; and act as an outcome measure of functional response to tDCS. In this systematic review we explore methodological parameter space of tDCS integration with fMRI. Existing tDCS-fMRI literature shows little replication across these permutations; few studies used comparable study designs. Here, we use a case study with both task and resting state fMRI before and after tDCS in a cross-over design to discuss methodological confounds. We further outline how computational models of current flow should be combined with imaging data to understand sources of variability in responsiveness. Through the case study, we demonstrate how modeling and imaging methodology can be integrated for individualized analysis. Finally, we discuss the importance of conducting tDCS-fMRI with stimulation equipment certified as safe to use inside the MR scanner, and of correcting for image artifacts caused by tDCS. tDCS-fMRI can address important questions on the functional mechanisms of tDCS action (e.g. target engagement) and has the potential to support enhancement of behavioral interventions, provided studies are designed rationally.
Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes (2002)

Experimental data support a role for FAK, an important component of the integrin signaling pathway, in insulin action. To test the hypothesis that FAK plays a regulatory role in hepatic insulin action, we overexpressed wild type (WT), a kinase inactive (KR), or a COOH-terminal focal adhesion targeting (FAT) sequence-truncated mutant of FAK in HepG2 hepatoma cells. In control untransfected (NON) and vector (CMV2)- and WT-transfected cells, insulin stimulated an expected 54 +/- 13, 37 +/- 4, and 47 +/- 12 increase in [U-(14)C]glucose incorporation into glycogen, respectively. This was entirely abolished in the presence of either KR (-1 +/- 7%) or FAT mutants (0 +/- 8%, n = 5, p < 0.05 for KR or FAT versus other groups), and this was associated with a significant attenuation of incremental insulin-stimulated glycogen synthase (GS) activity. Insulin-stimulated serine phosphorylation of Akt/protein kinase B was significantly impaired in mutant-transfected cells. Moreover, the ability of insulin to inactivate GS kinase-3beta (GSK-3beta), the regulatory enzyme immediately upstream of GS, by serine phosphorylation (308 +/- 16, 321 +/- 41, and 458 +/- 34 optical densitometric units (odu) in NON, CMV2, and WT, respectively, p < 0.02 for WT versus CMV2) was attenuated in the presence of either FAT (205 +/- 14, p < 0.01) or KR (189 +/- 4, p < 0.005) mutants. FAK co-immunoprecipitated with GSK-3beta, but only in cells overexpressing the KR (374 +/- 254 odu) and FAT (555 +/- 308) mutants was this association stimulated by insulin compared with NON (-209 +/- 92), CMV2 (-47 +/- 70), and WT (-39 +/- 31 odu). This suggests that FAK and GSK-3beta form both a constitutive association and a transient complex upon insulin stimulation, the dissociation of which requires normal function and localization of FAK. We conclude that FAK regulates the activity of Akt/protein kinase B and GSK-3beta and the association of GSK-3beta with FAK to influence insulin-stimulated glycogen synthesis in hepatocytes. Insulin action may be subject to regulation by the integrin signaling pathway, ensuring that these growth and differentiation-promoting pathways act in a coordinated and/or complementary manner.
Macrophage colony-stimulating factor in patients with rheumatoid arthritis. (1995)

Macrophage colony-stimulating factor (M-CSF) is a cytokine involved in the development and proliferation of the monocyte/macrophage lineage cells. M-CSF has also been reported to participate in the induction of osteoclasts, and may be important in the destruction of bone and cartilage and the periarticular osteoporotic changes seen in patients with rheumatoid arthritis (RA). We developed a new ELISA technique to measure M-CSF levels in synovial fluid with high sensitivity and reproducibility. The mean M-CSF level in the synovial fluid of patients with RA was 1.38 +/- 0.56 ng/ml, and that of patients with osteoarthritis (OA) was 0.67 +/- 0.13 ng/ml. In contrast, serum levels of M-CSF in patients with RA and in normal controls were 1.32 +/- 0.50 ng/ml and 0.90 +/- 0.09 ng/ml, respectively. These differences were both statistically significant. Since serum M-CSF levels correlate with inflammatory signs obtained from examination of blood, they indicate the general condition of patients with RA. Synovial fluid M-CSF levels increase even in the early phase of RA and remain high despite drug therapy, which suggests that they reflect the condition of affected joints including joint spaces and inflamed synovia more directly than do the levels of serum M-CSF. Measurement of the M-CSF level in the synovial fluid may be useful in the diagnosis, clinical evaluation, and assessment of the effects of treatment in patients with RA.
Shock wave demagnetization of BaFe12O19 hard ferrimagnetics (2002)

A study of the effect of shock waves on the phase state of a hard ferrimagnetic material has been performed. A plane shock wave was passed along the axis of a cylindrical BaFe12O19 hard ferrite magnet. The shock wave demagnetized the cylinder, reducing the magnetic flux. This change in magnetic flux generated an electromotive force (EMF) in a coil wound around the ferrite. The value of the EMF calculated on the assumption that the ferrite was completely demagnetized by the shock wave is in good agreement with the peak EMF value obtained experimentally.
Built-in testing of integrated circuit wafers (1990)

Production testing of a digital circuit requires the generation of a sequence of tests and their application to the circuit being tested. Currently, in test application, the output of the circuit under test is compared to a known correct output for each test. The method has some drawbacks likely to become more critical in the near future. In homogeneous systems of identical integrated circuits of silicon wafers, testing can be done in another way, i.e. by applying a common test to several processing elements at once and comparing the results produced by them. The authors analyze such schemes and show that they are inherently as accurate as current methods that use assumed correct results for production testing. Since this approach could allow wafers to be tested for production faults significantly more quickly than by using a probe tester, the results indicate that it can provide an attractive alternative to current methods for production testing of silicon wafers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Draft Genome Sequence of Mycobacterium bohemicum Strain DSM 44277 T (2015)

The Mycobacterium bohemicum strain is a nontuberculosis species mainly responsible for pediatric cervical lymphadenitis. The draft genome of M. bohemicum DSM 44277(T) comprises 5,097,190 bp exhibiting a 68.64% G+C content, 4,840 protein-coding genes, and 75 predicted RNA genes.
Vacuole Acidification Is Not Required for Survival of Salmonella enterica Serovar Typhimurium within Cultured Macrophages (2000)

Phagosome acidification is an important component of the microbicidal response by infected eukaryotic cells. Thus, intracellular pathogens that reside within phagosomes must either block phagosome acidification or be able to survive at low pH. In this work, we studied the effect of phagosomal acidification on the survival of intracellular Salmonella enterica serovar Typhimurium in different cell types. Bafilomycin A1, a specific inhibitor of the vacuolar proton-ATPases, was used to block acidification of salmonella-containing vacuoles. We found that in several epithelial cell lines, treatment with bafilomycin A1 had no effect on intracellular survival or replication. Furthermore, although acidification was essential for Salmonella intracellular survival in J774 cultured macrophages, as reported previously (13), it is not essential in other macrophage cell lines. These data suggest that vacuolar acidification may play a role in intracellular survival of salmonellae only under certain conditions and in specific cell types.
Synthesis and reactions of 3‐OXO‐2H‐furan derivatives (1973)

Abstract 2‐Alkyl‐4‐ethoxycarbonyl‐5‐methyl‐3‐oxo‐2 H ‐furans ( I, R ′ = Et) can be prepared at − 20° from ethyl acetoacetate and α‐bromo carboxylic acid chlorides. The furans do not enolize to hydroxyfurans, but behave essentially as unsaturated ketones towards various nucleophiles. With potassium hydroxide, ring opening and closure leads ultimately to 3‐acetyl‐5‐alkyl‐4‐hydroxy‐2‐oxo‐5 H ‐furans (II); with sodium methoxide the overall process is one of decarboxylation while oxidative decarboxylation with hydrogen peroxide in an alkaline medium yields 2‐alkyl‐4‐hydroxy‐5‐methyl‐3‐oxo‐2 H ‐furans (IV). As illustrated in Scheme 1 all three processes are thought to be initiated by the addition of a nucleophile (HO − , CH 3 O − , HOO − ) on the activated double bond in the furans.
Frequency of sister chromatid exchange in peripheral lymphocytes of male pesticide applicators (1991)

In the present study 61 male pesticide applicators who worked in cotton fields and regularly sprayed pesticides such as DDT, BHC, endosulfan, malathion, methyl parathion, phosphamidon, dimethoate, monocrotophos, quinalphos fenvelrate, and cypermethrin were analyzed for sister chromatid exchanges, mitotic index, and cell cycle kinetics in peripheral lymphocytes. Subjects who handled pesticides were non-smokers and teetotalers and the data were compared with the matched control group. Statistical analysis revealed that the frequency of sister chromatid exchanges was significantly higher among the pesticide applicators at all the durations of exposure when compared to controls. Subjects exposed to pesticides also showed cell cycle delay and decrease in mitotic index when compared to the control group.
Benzoato[hydrotris(3-phenylpyrazol-1-yl-N2)borato]zinc(II) (1995)

The structure of the title complex, [Zn{HB(C 9 H 7 N 2 ) 3 }(C 7 H 5 O 2 )], has been determined ; the central Zn atom is coordinated in a distorted tetrahedral environment by three N atoms, one from each pyrazole ring [Zn-N 2.038(5)-2.084(5) A], and by a benzoate O atom [Zn-O 1.935 (5) A]. A hydrophobic pocket is formed around the fourth coordination site of the Zn atom by the phenyl substituent on each pyrazole ring ; this pocket is occupied by the benzoate ligand.
Fusion proteins with chromogenic and keratin binding modules (2019)

The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide (KP). The KP-UM fusion protein explores UM chromogenic nature together with KP affinity towards hair. For the first time a fusion protein with a chromogenic nature is explored as a hair coloring agent. The KP-UM protein colored overbleached hair, being the color dependent on the formulation polarity. The protein was able to bind to the hair cuticle and even to penetrate throughout the hair fibre. Molecular dynamics studies demonstrated that the interaction between the KP-UM protein and the hair was mediated by the KP sequence. All the formulations recovered the mechanical properties of overbleached hair and KP-UM proved to be safe when tested in human keratinocytes. Although based on a chromogenic non-fluorescent protein, the KP-UM protein presented a photoswitch phenomenon, changing from chromogenic to fluorescent depending on the wavelength selected for excitation. KP-UM protein shows the potential to be incorporated in new eco-friendly cosmetic formulations for hair coloration, decreasing the use of traditional dyes and reducing its environmental impact.
Activity of self-depolarizing pacemaker cells bio-engineered in virtual heterogeneous ventricular tissue (2006)

Genetically engineered cardiac pacemakers are a proposed alternative or support to the state-of-the-art electronic devices. Down-regulation of the expression of Kir2.1 channels reduces the activity of the inward rectifier current IK1 and turns ventricular cardiomyocytes to pacemaker cells. This effect was mimicked in computational cells describing heterogeneous human ventricular electrophysiology by blocking the IK1 current. These intrinsic self-depolarizing cells were inserted into a long and thin parallelepipedal anatomical structure describing a ventricular strand from endocardium to epicardium. The width and position of the pacemaking region was variable. The required width for successfully driving the tissue mainly depended on the amount of adjacent normal ventricular myocytes. Attachment of the pacemaker region to any tissue boundary reduced the necessary size. The smallest width was required for attachment to the endocardium. The cycle length of spontaneous activation was smallest for endocardial attachment and decreased with the size of the self-depolarizing region.