gebhart/patrepeval huggingface dataset:
Global Register Partitioning (2000)

Modern computers have taken advantage of the instruction-level parallelism (ILP) available in programs with advances in both architecture and compiler design. Unfortunately, large amounts of ILP hardware and aggressive instruction scheduling techniques put great demands on a machine's register resources. With increasing ILP, it becomes difficult to maintain a single monolithic register bank and a high clock rate. To provide support for large amounts of ILP while retaining a high clock rate, registers can be partitioned among several different register banks. Each bank is directly accessible by only a subset of the functional units with explicit inter-bank copies required to move data between banks. Therefore, a compiler must deal not only with achieving maximal parallelism via aggressive scheduling, but also with data placement to limit inter-bank copies. Our approach to code generation for ILP architectures with partitioned register resources provides flexibility by representing machine dependent features as node and edge weights and by remaining independent of scheduling and register allocation methods. Experimentation with our framework has shown a degradation in execution performance of 10% on average when compared to an unrealizable monolithic-register-bank architecture with the same level of ILP.
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models (2019)

This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models, the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified by γ-secretase inhibition. Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset, progression and spreading.
Shifted plasmonic nanorods to enhance the density of hot-spots for surface-based nonlinear optics (2016)

Strong field enhancements are observed in the nano-gaps of plasmonic nanostructures. We propose a novel structure made of shifted nanorods to maximize the density of hot-spots, which is a crucial parameter for surface-based nonlinear optics.
UV‐curable thio‐ether‐urethane network with tunable properties (2016)

ABSTRACT A photoinitiating system composed of a sensitizer (isopropylthioxanthone, ITX) and a photobase generator (triazabicyclodecene tetraphenylborate TBD.HBPh4) was successfully applied to the photopolymerization of a thiol‐isocyanate‐epoxy mixture. The final polymer network was considered in term of the compositional ratio between the thiol‐isocyanate and thiol‐epoxy coupling reactions. In parallel with structural investigation by spectroscopic technics, the relationships between the compositional ratio and kinetics of photopolymerization, thermomechanical properties and hardness were investigated. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 3119–3126
An Acoustic Phase Shift Technique for the Non-Invasive Measurement of Temperature Changes in Tissues (1985)

An acoustic phase shift technique for non-invasive measurement of temperature changes in tissues is described, The technique uses a tone burst to monitor acoustic phase shifts which are correlated with temperature changes from the temperature dependence of the acoustic propagation velocity. The stability and accuracy of the system are discussed. Results o f i n-vitro experiments in beef and in-vivo experiments o n a renal adenocarcinoma I mplanted subcutaneously in a rat during local hyperthermia by scanned focused ultrasound are described. A high correlation between the change in acoustic propagation velocity and the peak measured temperature is reported. Ektension of the technique to clinical use is discussed.
Separation and characterization of very large neutral polycyclic molecules in fossil fuels by microcolumn liquid chromatography and mass spectrometry (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation and characterization of very large neutral polycyclic molecules in fossil fuels by microcolumn liquid chromatography and mass spectrometryMilos. Novotny, Akio. Hirose, and Donald. WieslerCite this: Anal. Chem. 1984, 56, 8, 1243–1248Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ac00272a012https://doi.org/10.1021/ac00272a012research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gender Differences in Suicidal Behavior in Korea (2008)

Our study should be understood within the context of the specific cultural background of South Korea. We found that males and females use similar methods when attempting suicide and share a similar ambivalence regarding the outcome of the attempt; however, there was a difference in severity of the attempt between the two groups. Our findings may aid in the identification of more effective methods of intervention to prevent suicide.
An Enhanced Control System for Single-Phase Inverters Interfaced With Weak and Distorted Grids (2019)

This paper presents an enhanced current controller for improving the performance of a class of single-phase grid-connected inverters operating in weak and distorted grid conditions. An inverter designed to operate at normal (strong or stiff and clean) grid conditions may not perform satisfactorily during weak and distorted grid conditions. One major reason is the interfering dynamics of the synchronization or phase-locked loop (PLL). This paper proposes an enhanced control structure for a popular class of single-phase inverters to address this problem. The proposed idea is to include the PLL state variables into the main inverter controller thereby minimizing the undesirable interactions of the PLL with the other components. A method for optimally designing the controller gains is also proposed. Compared to the conventional one, the proposed controller is shown to have a more robust performance over a substantially wider range of weak and distorted grid conditions. Extensive simulation and experimental results are presented to validate the proposed controls.
A New Clustering-based Radio Resource Allocation Scheme for C-V2X (2021)

The Cellular Vehicle-to-Everything (C-V2X) is an emerging technology for vehicular networks in which resource allocation mechanisms play a crucial role in its overall performance. In C-V2X, there are two resource allocation modes known as mode 3 and mode 4. This study focuses on mode 3 where the resources are scheduled and allocated by the eNB to vehicles. Contrary to mode 4, the 3GPP has not standardized a specific resource allocation algorithm for mode 3. In this context, we propose in this paper, a new clustering-based resource allocation algorithm for mode 3, named Maximum Inter-Centroids Reuse Distance (MIRD). The main goal of our scheduling scheme is to efficiently allocate resources to vehicles with the application of a specific resource reuse mechanism between clusters. MIRD scheduling scheme is validated through simulations in realistic urban scenario, conducted using the LTEV2VSim simulator. The results demonstrate that our proposed algorithm outperforms another reference algorithm for mode 3 found in the literature.
Eravacycline (TP-434) Is Efficacious in Animal Models of Infection (2015)

Eravacycline is a novel broad-spectrum fluorocycline antibiotic being developed for a wide range of serious infections. Eravacycline was efficacious in mouse septicemia models, demonstrating 50% protective dose (PD50) values of ≤ 1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50 values against Escherichia coli isolates were 1.2 to 4.4 mg/kg q.d. In neutropenic mouse thigh infection models with methicillin-sensitive S. aureus (MSSA) and S. pyogenes, eravacycline produced 2 log10 reductions in CFU at single intravenous (i.v.) doses ranging from 0.2 to 9.5 mg/kg. In a neutropenic mouse lung infection model, eravacycline administered i.v. at 10 mg/kg twice a day (b.i.d.) reduced the level of tetracycline-resistant MRSA in the lung equivalent to that of linezolid given orally (p.o.) at 30 mg/kg b.i.d. At i.v. doses of 3 to 12 mg/kg b.i.d., eravacycline was more efficacious against tetracycline-resistant Streptococcus pneumoniae in a neutropenic lung infection model than linezolid p.o. at 30 mg/kg b.i.d. Eravacycline showed good efficacy at 2 to 10 mg/kg i.v. b.i.d., producing up to a 4.6 log10 CFU reduction in kidney bacterial burden in a model challenged with a uropathogenic E. coli isolate. Eravacycline was active in multiple murine models of infection against clinically important Gram-positive and Gram-negative pathogens.
Surface Effects of Quench Methodology on Lithium Rich Nickel Manganese Oxide Cathode Particles (2022)

Our investigation found that rapid cooling, through use of a water quench, of layered lithium rich nickel manganese oxide (LLRNMO) cathodes, post 900 °C calcination, resulted in cathode materials with significantly improved electrochemical performance and more homogenous physio-structural properties near the surfaces. Our investigation was conducted on LLRNMO from the Li[Ni x Li (1/3-2x/3) Mn (2/3-x/3) ]O 2 compositional series, where x = 0.25. Our material was prepared using a hybrid sol-gel route where the post 900 °C cooling step was varied between the two extremes, rapid quenching through water immersion (sample Wq), and slow natural oven cooling (sample Oc). Surface analysis of these samples was conducted before and after repeated galvanostatic-static constant-current potential limited (GCPL) cycling of coin cells with cathodes made of these active materials to elucidate any electrochemical effects that could arise from the physio-structural differences between the samples. Surface analysis was conducted using high resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM), energy dispersive spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). The rapidly quenched Wq samples were found to have higher specific capacities, higher average discharge voltages, greater cycle stability, and greater voltage stability when compared to the Oc samples. This is consistent with one of our previous investigations. 1 Surface studies of the samples revealed that the pristine Oc samples had evidence of phase segregation between the nickel poor bulk phase and a nickel rich surface phase. These two phases were reminiscent of a core/shell architecture. Surface analysis conducted after the course of cycling suggested that the concentration of transition metals homogenized over the course of cycling, resulting in less distinction between the surface and bulk phases, as well as the nucleation of defect phases. These behaviors of the Oc samples are in large contrast to the Wq samples’ where the surface and bulk phases were isostructural with more homogenous concentrations of transition metals. These data suggest that more rapidly quenched samples see increased stabilization of the meta-stable R-3m phase resulting in the reported superior electrochemical properties. S. Burke and J. F. Whitacre, J. Electrochem. Soc. , 167 , 160518 (2020). Figure 1
Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles (2020)

Sea turtles have been proposed as health indicators of marine habitats and carriers of antibiotic-resistant bacterial strains, for their longevity and migratory lifestyle. Up to now, a few studies evaluated the antibacterial resistant flora of Mediterranean loggerhead sea turtles (<i>Caretta caretta</i>) and most of them were carried out on stranded or recovered animals. In this study, the isolation and the antibiotic resistance profile of 90 Gram negative bacteria from cloacal swabs of 33 Mediterranean wild captured loggerhead sea turtles are described. Among sea turtles found in their foraging sites, 23 were in good health and 10 needed recovery for different health problems (hereafter named weak). Isolated cloacal bacteria belonged mainly to Enterobacteriaceae (59%), Shewanellaceae (31%) and Vibrionaceae families (5%). Although slight differences in the bacterial composition, healthy and weak sea turtles shared antibiotic-resistant strains. In total, 74 strains were endowed with one or multi resistance (up to five different drugs) phenotypes, mainly towards ampicillin (~70%) or sulfamethoxazole/trimethoprim (more than 30%). Hence, our results confirmed the presence of antibiotic-resistant strains also in healthy marine animals and the role of the loggerhead sea turtles in spreading antibiotic-resistant bacteria.
Transbuccal Absorption of Diclofenac Sodium in a Dog Model (1987)

The buccal permeability of the non-steroidal antiinflammatory drug, diclofenac sodium, has been evaluated in a dog model. The dog was selected because of the similarity of its buccal mucosa to that of man. Analysis of the buccal data indicated that diclofenac sodium permeability followed an essentially zero-order kinetic process with a minimal lag phase. Permeability of the drug was estimated to be 3 mg/cm2.h but significant differences were observed between animals. The absorption rate with the transbuccal delivery device decreased with time whereas the corresponding rate with a saturated solution was constant. This difference was attributed to the time dependency of drug delivery from the device and was modeled on the basis of release from a membrane-ispersed monolith combined with constant buccal permeability. The predictions of the model showed excellent agreement with the experimental data.
Studies on the Compounds related to Colistin. IX. On the Chemical Deacylation of Colistin and Colistin Derivatives (1974)

In order to investigate the deacylation of colistin or colistin derivatives with the free amino group protected, these compounds were treated with various acids. De-acylcolistin was obtained by reaction of colistin with 6N formic acid for 7 hr at 70° or with 1N oxalic acid for 9 hr at 70°. Pentabenzyloxycarbonylcolistin gave its deacylated compound when treated with 11N formic acid for 4 hr at 70° or with 1N oxalic acid for 4 hr at 50°. Deacylation of penta-tert-butoxycarbonylcolistin was carried out by its reaction with 11N formic acid for 4 hr at 70° or with 1N oxalic acid for 4 hr at 50°.
Nano-imprint lithography for single electron tunneling devices using novel mold (2003)

A novel mold fabrication method for nano-imprint lithography is newly proposed. Utilizing anisotropic wet chemical etching, the mold formation having narrow gaps is principally confirmed, which would be useful for fabrication of tunneling barriers for single electron devices by imprinting lithography.
Investigation of Experimental Parameters with a Quadrupole ICP/MS (1987)

Preliminary studies have shown that signal behavior in ICP/MS is quite different from that in ICP-OES. This is particularly true for the manner in which ICP operating parameters affect the responses of elements detected, and results from behavior occurring both in the interface and in the mass spectrometer. This paper describes in detail the response of a commercially available instrument (VG PlasmaQuad) to variations in several important operating parameters. The effects of nebulizer flow rate, rf plasma power, and sampling depth on ion populations, on ratios of singly charged to doubly charged ions, and on singly charged ions to oxide and hydroxide ions are described for selected elements. A comparison is also made of the results obtained with the present instrument, with data published from other commercial instrumentation.
Development of an autonomous underwater vehicle for survey of cobalt-rich manganese crust (2015)

AUV BOSS-A with visual and acoustic instrument device has been developed to survey manganese crusts located at the depth of 1,000 to 2,400 m. The AUV navigates at constant speed and altitude along waypoints with primary set, and automatically observes the seafloor by developed instruments. Visual instrument device mounted on the AUV creates 3D color reconstruction which shows the condition and the distribution of manganese crusts. Mounted acoustic instrument device is able to measure manganese crusts thickness. This paper describes the system and survey method of the AUV BOSS-A and survey results of sea trial for the demonstration of the manganese crust survey using the AUV. Survey results shows that manganese crusts with thickness of 15 to 45 mm are distributed at Katamaya sea mount. coustic instrument devices.
Synthesis of regioisomeric analogues of crisamicin A (2003)

The synthesis of bis-furonaphthopyrans 12a and 12b, regioisomeric analogues of the dimeric pyranonaphthoquinone antibiotic crisamicin A 1 is described. The key intermediate 16 was prepared via a one-pot in situ Suzuki-Miyaura homocoupling of naphthyl triflate 23 using bis(pinacolato)diboron. Oxidation of binaphthyl 16 to bis-naphthoquinone 14 was then effected with silver(II) oxide and nitric acid. Efficient double furofuran annulation of bis-naphthoquinone 14 with 2-trimethylsilyloxyfuran 8 afforded bis-furonaphthofuran adducts 13a and 13b as an inseparable 1:1 mixture of diastereomers. Oxidative rearrangement of this mixture of bis-furonaphthofuran adducts 13a and 13b using silver(II) oxide and nitric acid afforded unstable bis-furonaphthopyrans 12a and 12b also as a 1:1 mixture of diastereomers. Addition of 2-trimethylsilyloxyfuran 8 to naphthoquinone 25 afforded adduct 26 that underwent oxidative rearrangement to furonaphthopyran 27, however attempts to effect Suzuki-Miyaura homocoupling of triflates 26 and 27 to their respective dimers 13 and 12, was unsuccessful.
Psychologists seek the unexpected, not the negative, to provoke innovative theory construction (2004)

Krueger &amp; Funder (K&amp;F) see social psychologists as driven to demonstrate that people's behavior falls below relevant moral and intellectual standards. We suggest that social psychologists search for demonstrations of when it is that people's actual behaviors and decisions deviate from expected or ideal behaviors and decisions, and what these “deviations” tell us about general decision processes, including those that do not produce unexpected actions. Often the discoveries are of positive rather than negative behaviors.
Diurnal variations in serum biochemical and haematological measurements. (1989)

Twenty five biochemical and haematological measurements were determined on nonfasting blood and serum samples collected between 9 am and 7 pm from a representative group of 7685 British middle-aged men. Most measurements showed significant diurnal variations, but only for bilirubin, phosphate, and triglyceride did time of day account for more than 5% of the between subject variance. Serum bilirubin concentrations showed a pronounced downward trend in the afternoon, the mean value after 6 pm being 30% lower than the mean value in the morning. Mean serum triglyceride and phosphate concentrations increased steadily through the day. Mean concentrations of potassium, haemoglobin, and haematocrit and red cell count were higher in the morning, while urea and creatinine concentrations and white cell count had higher means in the afternoon. Glucose showed a pattern consistent with short term response to meals. The effects of these diurnal trends on routine use of biochemical tests needs careful consideration, and a greater understanding of their biological mechanisms is required.
Development of an improved carbon electrode chemically modified with cobalt phthalocyanine as a re-usable sensor for glutathione (1989)

Cyclic voltammetry, differential-pulse voltammetry (DPV), amperometry and flow injection with electrochemical detection were used to investigate the electrochemical behaviour of reduced glutathione (GSH) at a carbon paste electrode and also at a carbon paste electrode doped with cobalt phthalocyanine (CPC). The modified electrode was found to reduce greatly the overpotential necessary for the oxidation of GSH at the electrode surface; the process was dependent on the ionic strength and pH of the supporting electrolyte. The oxidation of GSH in the presence of CPC was found to occur at two potentials, 0.27 and 0.75 V versus a saturated calomel electrode. Using DPV the first wave was found to give optimum sensitivity for the measurement of GSH concentations in the range 2.5 × 10–6–6.25 × 10–5M; whereas the second was preferential for GSH concentrations of 1.25 × 10–4–2.5 × 10–3M. Electrode deterioration rendered the other techniques unsuitable for routine quantitative analyses. Similar investigations were also carried out on a carbon-epoxy resin composite electrode containing CPC; the various techniques were used to optimise the electrode response for the determination of GSH in biological fluids. This electrode was found to be superior to the graphite paste electrode as GSH could be determined in flowing or stirred solutions. The modified composite electrode was stable and could be used over a period of at least 10 h. The limits of detection were 10 ng ml–1 and 450 pg injected on column for amperometry and high-performance liquid chromatography with electrochemical detection (LCEC), respectively. Preliminary studies using LCEC have shown that the method is suitable for the determination of circulating levels of GSH in human plasma.
Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1? mRNA in ischemic brain tolerance (2000)

A short duration of ischemia (i.e., ischemic preconditioning) was shown to result in significant tolerance to subsequent ischemic injury. Since previous reports suggest that interleukin-1beta (IL-1beta) may be involved in both ischemic damage and neuroprotection, the present work examined the expression of IL-1beta mRNA in cortical brain tissue after an established preconditioning (PC) stimulus known to produce significant brain tolerance to focal stroke after 1-7 days. Significant induction of IL-1beta mRNA was observed in the ipsilateral cortex at 6 hr (87+/-9 copies of the mRNA per microgram of brain tissue compared to 16+/-5 copies in sham-operated samples, P < 0.001, n = 4) and 8 hr (46+/-4 copies, P < 0.01, n = 4) after PC by means of real-time Taqman polymerase chain reaction (PCR). The peak expression of IL-1beta mRNA after PC was significantly (P < 0.01) lower than that after permanent occlusion of the middle cerebral artery (MCAO), i.e., 87+/-9 and 546+/-92 copies of RNA per microgram tissue at peak levels for PC and focal stroke, respectively. Immunohistochemistry studies revealed a parallel induction of IL-1beta in the ipsilateral cortex after PC. The maximal expression of IL-1beta was observed during the first week post-PC, showing marked parallelism with the duration of ischemic tolerance. These data suggest that the significant but low levels of IL-1beta induction after PC may contribute to ischemic brain tolerance.