gebhart/patrepeval huggingface dataset:
Supplementary Figure 3C from BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma (2023)

&lt;p&gt;Alteration of total protein amount of MEK1, ERK1/2, c-Jun, Akt and ATF2 by MAPK inhibition. Total amount of MEK1, ERK1/2, c-Jun, Akt and ATF2 of HepG2 (A), Hep3B (B) and Huh-7 (C) cells after treatment with 0.2, 1 or 5µM sorafenib, PLX4720, U0126, AZD6244, PD0325901, GW5074 or sunitinib at different time points.&lt;/p&gt;
Abnormalities of Cilia in the Middle Ear in Chronic Otitis Media (1988)

We studied the fine structure of nasal and middle ear mucosa in 18 patients with chronic otitis media, comparing them with ten age-matched control patients. Electron microscopy revealed no single fundamental defect of cilia in the tissue samples; however, patients with chronic otitis media had a significantly higher incidence of abnormal cilia in the middle ear without correlating abnormalities of nasal cilia. These findings indicated that ciliary anomalies, including deletion of ciliary microtubules, presence of supernumerary tubules, and fusion of cilia, occur as a result of infection or inflammation. Such abnormalities would impair normal mucociliary clearance and exacerbate clinical complications.
Theoretical Considerations Of The Influence Of Mechanical Uniaxial Stress On Pixel Readout Circuits (2012)

In this work the effects of uniaxial mechanical stress on a pixel readout circuit are theoretically analyzed. It is the effects of mechanical stress on the in-pixel transistors do not arise at the output, when a correlated double sampling circuit is used. However, mechanical stress effects on the photodiode will directly appear at the readout chain output. Therefore, compensation techniques are needed to overcome this situation. Moreover simulation technique of mechanical stress is proposed and diverse layout as well as design recommendations are put forward, in order to minimize stress related effects on the output of a circuit. he shown, that wever, Moreover, a out
Targeted drug delivery to mammalian mitochondria in living cells (2005)

Mitochondrial dysfunction causes or contributes to a large number of human disorders including neuromuscular and neurodegenerative diseases, diabetes, ischaemia-reperfusion injury and cancer. Increasing efforts are being made towards mitochondria-directed pharmacological intervention, leading to the emergence of 'mitochondrial medicine' as a new field of biomedical research. The identification of new molecular mitochondrial drug targets in combination with the development of methods for selectively delivering biologically active molecules to the site of mitochondria will eventually launch new therapies for the treatment of mitochondria-related diseases, based either on the selective protection, repair or eradication of cells. This review discusses the need for the development of mitochondria-specific drug and DNA delivery systems, and evaluates the currently employed strategies for mitochondrial drug targeting, including some of their potential therapeutic applications.
Contribution of the crystalline lens gradient refractive index to the accommodation amplitude in non-human primates: In vitro studies (2011)

The purpose of this study was to determine the contribution of the gradient refractive index to the change in lens power in hamadryas baboon and cynomolgus monkey lenses during simulated accommodation in a lens stretcher. Thirty-six monkey lenses (1.4-14.1 years) and twenty-five baboon lenses (1.8-28.0 years) were stretched in discrete steps. At each stretching step, the lens back vertex power was measured and the lens cross-section was imaged with optical coherence tomography. The radii of curvature for the lens anterior and posterior surfaces were calculated for each step. The power of each lens surface was determined using refractive indices of 1.365 for the outer cortex and 1.336 for the aqueous. The gradient contribution was calculated by subtracting the power of the surfaces from the measured lens power. In all lenses, the contribution of the surfaces and gradient increased linearly with the amplitude of accommodation. The gradient contributes on average 65 ± 3% for monkeys and 66 ± 3% for baboons to the total power change during accommodation. When expressed in percent of the total power change, the relative contribution of the gradient remains constant with accommodation and age in both species. These findings are consistent with Gullstrand's intracapsular theory of accommodation.
Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR (2017)

The proposed bead-beating CSP-ELISA/qPCR methodology considerably increases throughput for the detection of mosquito infection. qPCR remains necessary to confirm infections in mosquitoes with low CSP-ELISA signal. This methodology may prove particularly useful for studies where very low mosquito infection prevalence is expected and study sites where experience with oocyst detection is limited.
Nonlinear Analysis of Pulsating Instabilities in Diffusion Flames (2005)

Recent experiments of diffusion flames have identified fascinating nonlinear behavior, especially near the extinction limit. In this work, we carry out a systematic analysis of pulsating instabilities in diffusion flames. We consider the simple geometric configuration of a planar diffusion flame situated in a channel at the interface between a fuel being supplied from below, and oxidant diffusing in from a stream above. Lewis numbers are assumed greater than unity in order to focus on pulsating instabilities. We employ the asymptotic theory of Cheatham and Matalon, and carry out a bifurcation analysis to derive a nonlinear evolution equation for the amplitude of the perturbation. Our analysis predicts three possible flame responses. The planar flame may be stable, such that perturbations decay to zero. Second, the amplitude of a perturbation can eventually become unbounded in finite time, indicating flame quenching. And finally, our amplitude equation possesses timeperiodic (limit cycle) solutions, although we find that this regime cannot be realized for parameter values typical of combustion systems. The various possible burning regimes are mapped out in parameter space, and our results are consistent with available experimental and numerical data.
A Novel Location Management Scheme for Wireless Mesh Networks (2009)

Conventional location management schemes are not designed for Wireless mesh networks and result in considerable signaling cost if used directly in the circumstance. In this paper, a Cluster-based location management scheme is introduced, which takes adequately into account the characteristic of the mesh structure. Numerical result reveals that the proposed scheme enables to significantly lessen the signaling cost.
Polyphenolic content and antioxidant activity of an extractive fraction from Abies alba bark. (2014)

The ability of the ethyl acetate fraction to scavenge free radicals and chelate ferrous ions justifies further studies on the possible therapeutic applications of its antioxidant potential.
High-resolution incoherent imaging of crystals (1990)

A Bloch-wave analysis shows how a signal dependent on the electron intensity at the atom sites can be used to form an incoherent image of a crystal structure. To a good approximation the image is given by a convolution of a compositionally sensitive object function with an appropriate resolution function, and as such can be predicted and interpreted intuitively. Information on a scale below the resolution limit can be interpreted by deconvolution.
Figure S2 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk (2023)

&lt;p&gt;Figure S2. Biologic Signature Interrogates Comprehensive Set of Pathways.&lt;/p&gt;
ChemInform Abstract: An Easy Access to Enantio‐Enriched α‐Substituted Aldehydes by Carbolithiation of β‐Phenyl or β‐Silyl‐α,β‐ethylenic Aldehydes, Protected with the Monolithioamide of a Chiral Diamine. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Case of Sigmoid Colon Cancer Accompanied by an Inverted Cecum Successfully Treated with Laparoscopic Surgery (2021)

症例は40歳，男性．早期S状結腸癌に対し内視鏡的粘膜切除を施行後，病理組織的診断結果から追加切除の適応で手術目的に当科へ紹介となった．術前画像検査で，盲腸および虫垂が右上前腸骨棘の高さに位置し，盲腸の盲端側が頭側に向いている腸回転異常の亜型を伴っており，右側結腸の大半はそのまま骨盤腔に下降しているのが確認できた．この形態をinverted cecumと表現している成書もある．腹部造影CTでは腹腔内遠隔転移やリンパ節腫大，SMV rotation signも認めず，型の如く腹腔鏡下S状結腸切除術を施行した．腸回転異常症の亜型で，このような形姿をなす報告例は認めていないが，腹腔鏡下でもS状結腸より肛門側の手術であれば解剖学的に大きな問題はなく，安全に手術を施行しえた1例を経験したので報告する．
Deubiquitylation Regulates Activation and Proteolytic Cleavage of ENaC (2008)

The epithelial sodium channel (ENaC) is critical for sodium and BP homeostasis. ENaC is regulated by Nedd4-2-mediated ubiquitylation, which leads to its internalization; this process can be reversed by deubiquitylation, which is regulated by the aldosterone-induced enzyme Usp2-45. In a second regulatory pathway, ENaC can be activated by luminal serine protease-mediated cleavage of its extracellular loops. Whether these two regulatory processes interact, however, is unknown. Here, in HEK293 cells stably transfected with ENaC, Usp2-45 interacted with ENaC, leading to deubiquitylation of the channel and stimulation of ENaC activity >20-fold. This was accompanied by a modest increase in cell surface expression of ENaC and by proteolytic cleavage of alphaENaC and gammaENaC at their extracellular loops. When endocytosis was inhibited with dominant negative dynamin (DynK44R), channel density and gammaENaC cleavage were increased, but alphaENaC cleavage and ENaC activity were not augmented. When Usp2-45 was coexpressed with DynK44R, both alphaENaC cleavage and activity were recovered. In summary, these data suggest that Usp2-45 deubiquitylation of ENaC enhances the proteolytic activation of both alphaENaC and gammaENaC, possibly by inducing a conformational change and by interfering with endocytosis, respectively.
Student as Institutional Mirror (2011)

Jeff Davis explains how the challenges of students on the autism spectrum shine a light on the often-invisible impediments of first-generation students.
High cycle fatigue life estimation of AlSi10Mg processed by laser powder bed fusion (2018)

Fatigue life is known to be dependent on the surface properties of the material. Surface roughness provokes local stress concentration and cause crack initiation even at minute cyclic loads. In laser powder bed fusion, the as-built surfaces show variable roughness depending on the orientation of the specimens with respect to the build plate. In order to analyse the effect of build angle on surface properties, flat tensile specimens were produced from an AlSi10Mg alloy in a Concept Laser M2 Cusing machine. Seven specimens were arranged from flat to perpendicular with respect to the build plate at 15° intervals. The as-built surface topography of each specimen was characterised by white light interferometry. Two methods for calculating the stress concentration factor for high cycle fatigue simulation were developed. The presence of subsurface porosity was a crucial factor in expanding the stress concentration as demonstrated by finite element analysis.
Combination Antibiotic Treatment with Clarithromycin for Human Immunodeficiency Virus-Associated Rhodococcus equi Infection (1993)

Journal Article Combination Antibiotic Treatment with Clarithromycin for Human Immunodeficiency Virus-Associated Rhodococcus equi Infection Get access Gilles Pialoux, Gilles Pialoux Department of Infectious and Tropical Diseases and of Molecular Microbial Pathogenesis, Pasteur Institute; and Department of Medical Microbiology, St. Joseph Hospital, Paris, France Reprints or correspondence: Dr. Gilles Pialoux, Department of Infectious Diseases, Hôpital de l'Institut Pasteur, 209 rue de Vaugirard, 75015 Paris, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Fred Goldstein, Fred Goldstein Department of Infectious and Tropical Diseases and of Molecular Microbial Pathogenesis, Pasteur Institute; and Department of Medical Microbiology, St. Joseph Hospital, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Bertrand Dupont, Bertrand Dupont Department of Infectious and Tropical Diseases and of Molecular Microbial Pathogenesis, Pasteur Institute; and Department of Medical Microbiology, St. Joseph Hospital, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Gustavo Gonzalez Canali, Gustavo Gonzalez Canali Department of Infectious and Tropical Diseases and of Molecular Microbial Pathogenesis, Pasteur Institute; and Department of Medical Microbiology, St. Joseph Hospital, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Sansonetti Philippe Sansonetti Department of Infectious and Tropical Diseases and of Molecular Microbial Pathogenesis, Pasteur Institute; and Department of Medical Microbiology, St. Joseph Hospital, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 17, Issue 3, September 1993, Pages 513–514, https://doi.org/10.1093/clinids/17.3.513 Published: 01 September 1993
Self-Attention Channel Combinator Frontend for End-to-End Multichannel Far-Field Speech Recognition (2021)

When a sufficiently large far-field training data is presented, jointly optimizing a multichannel frontend and an end-to-end (E2E) Automatic Speech Recognition (ASR) backend shows promising results. Recent literature has shown traditional beamformer designs, such as MVDR (Minimum Variance Distortionless Response) or fixed beamformers can be successfully integrated as the frontend into an E2E ASR system with learnable parameters. In this work, we propose the self-attention channel combinator (SACC) ASR frontend, which leverages the self-attention mechanism to combine multichannel audio signals in the magnitude spectral domain. Experiments conducted on a multichannel playback test data shows that the SACC achieved a 9.3% WERR compared to a state-of-the-art fixed beamformer-based frontend, both jointly optimized with a ContextNet-based ASR backend. We also demonstrate the connection between the SACC and the traditional beamformers, and analyze the intermediate outputs of the SACC.
Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms (2019)

This study failed to detect a difference in change of anxiety between bipolar depressed patients treated with supraphysiologic doses of L-T4 or placebo. Comorbid anxiety symptoms should not be considered a limitation for the administration of supraphysiologic doses of L-T4 refractory bipolar depressed patients. Trial registration ClinicalTrials, ClinicalTrials.gov identifier: NCT01528839. Registered 2 June 2012-Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT01528839.
Laser or Razor? A Novel Experimental Peripheral Nerve Repair Technique (1988)

An operative repair technique for crushed sciatic nerve in the rat was used to examine whether removal of the damaged tissue could be better achieved with a low wattage CO2 laser or a blade. This approach was compared to results in rats undergoing conventional end-to-end nerve anastomosis using a microsurgical approach. Crushed sciatic nerves were exposed bilaterally 24 hours after injury and treated as follows. A longitudinally split polyethylene catheter was placed under the nerve, which was fixed to the catheter with 9-0 stitches placed away from lesion area; the nerve was bathed in ice-cold polyvinyl alcohol/chlorpromazine (PVA/CPZ) solution. After the nerve was crushed, the lesioned tissue was removed using laser pulses or a thin blade. A collagen matrix was used to fill the gap, and the preparation was covered and allowed to recover for 6 weeks. End-to-end anastomosis was done following same parameters, but with omission of the nerve catheter, PVA/CPZ solution, and collagen matrix; these nerves were reunited using epineurial stitches. High performance liquid chromotography (HPLC) analysis of each group showed that the laser approach reduced the levels of norepinephrine distal to the lesion, least, suggesting better regeneration of proximal axonal growth. Morphological and neuroelectric findings, although suggestive, showed no significant differences between laser and blade repair, a finding that reinforces the idea that such endpoints are not as sensitive as chemical assays of tissue transmitter levels such as HPLC. Laser or blade repair using nerve-catheter fixation and collagen bridge matrix was superior to end-to-end nerve anastomosis when morphological, neuroelectric, and HPLC values were compared in this model.(ABSTRACT TRUNCATED AT 250 WORDS)
Cripto/GRP78 modulation of the TGF‐β pathway in development and oncogenesis (2012)

Cripto is a small, GPI-anchored signaling protein that regulates cellular survival, proliferation, differentiation and migration during normal developmental processes and tumorigenesis. Cripto functions as an obligatory co-receptor for the TGF-β ligands Nodal, GDF1 and GDF3 but attenuates signaling of others such as activin-A, activin-B and TGF-β1. Soluble, secreted forms of Cripto also activate Src, ras/raf/MAPK and PI3K/Akt pathways via a mechanism that remains largely obscure. This review describes the biological roles and signaling mechanisms of Cripto, highlighting our identification of the 78 kDa glucose regulated protein (GRP78) as a cell surface receptor/co-factor required for Cripto signaling via both TGF-β and Src/MAPK/PI3K pathways. We discuss emerging evidence indicating that Cripto/GRP78 signaling regulates normal somatic stem cells and their tumorigenic counterparts.
Reconstruction of signal phases for signals closer than the DFT frequency resolution (2021)

Abstract. Radar signal processing is a promising tool for vital sign monitoring. For contactless observation of breathing and heart rate a precise measurement of the distance between radar antenna and the patient's skin is required. This results in the need to detect small movements in the range of 0.5 mm and below. Such small changes in distance are hard to be measured with a limited radar bandwidth when relying on the frequency based range detection alone. In order to enhance the relative distance resolution a precise measurement of the observed signal's phase is required. Due to radar reflections from surfaces in close proximity to the main area of interest the desired signal of the radar reflection can get superposed. For superposing signals with little separation in frequency domain the main lobes of their discrete Fourier transform (DFT) merge into a single lobe, so that their peaks cannot be differentiated. This paper evaluates a method for reconstructing the phase and amplitude of such superimposed signals.
Generation oftransgenic micewithelevated bloodpressure by introduction oftheratrenin andangiotensinogen genes (1990)

ABSTRACT The role of the renin-angiotensin system inblood pressurecontrol andin thedevelopmentofhypertension was investigatedbygeneratingtransgenicmicecarryingthe rat reninorangiotensinogengeneorbothgenesunderthecontrol of the mouse metallothionein I promoter. The systolic blood pressurewassignificantlyelevatedintransgenicmicecarrying both transgenesbutwasmaintainednormally in thosebearingeither of the transgenes. The transgene was effectively and properly transcribed to formthe maturemRNAin the trans-genicmice.Theproductionofratrenin and angiotensinogen in thetransgenicmicecarryingthecorrespondingtransgenewas also verified by immunoanalyses of these proteins. Further-more, the specific angiotensin-converting enzyme inhibitorcaptopril waseffective inreducingtheelevatedbloodpressure of thehypertensivetransgenic mice. Theseresultsindicate that the combinedaction ofthe exogenousrat renin andangioten-sinogen is responsible and necessary for elevation of bloodpressure in the hypertensive transgenic mice.The renin-angiotensin system consists ofthree major com-ponents: angiotensinogen, renin (EC 3.4.23.15), and an-giotensin-convertingenzyme(dipeptidylcarboxypeptidaseI,peptidyl-dipeptide hydrolase, EC3.4.15.1) (1, 2). Angioten-sinogenis mainlysynthesizedin
A LABORATORY STUDY OF SEDIMENT TRANSPORT CAPACITY IN THE DYNAMIC PROCESS OF RILL EROSION (2001)

The transport capacity of flowing water in a rill is one of the important parameters in soil erosion, especially insoil erosion prediction and soil erosion process modeling. Theory suggests that under steady flow, sediment yield will increasewith slope length and will approach its limit: the highest possible sediment concentration at transport capacity of the flow.The objective of this study was to develop a method to measure transport capacity of flow. A series of 405 flume experimentswere conducted with a siltyclay (loess) soil. A mathematical expression was presented to estimate transport capacity fromthe experimental data under five slopes (5, 10, 15, 20, 25), and three flow rates (2, 4, 8 l/min). The transport capacityis simply given as the product of unitwidth flow rate with the limit value of the sediment function with rill length. Transportcapacity was found to be related to slope and flow rate. For practical purposes, a method was suggested to estimate the rilllength required for determining transport capacity at different slope and flow rate.
A 240×180 10mW 12us latency sparse-output vision sensor for mobile applications (2013)

This paper proposes a 0.18um CMOS vision sensor that combines event driven asynchronous readout of temporal contrast with synchronous frame-based active pixel sensor readout of intensity. The sensor is suitable for mobile applications because it allows low latency at low data rate and therefore, low system-level power consumption. The image frames can be used for scene analysis and the temporal contrast events with 12us latency can be used to track fast moving objects. © 2013 JSAP.
The Influence of Lateral Load Transfer Distribution on Directional Response (1993)

&lt;div class="htmlview paragraph"&gt;Lateral load transfer occurs when vehicles engage in directional maneuvers. The distribution of lateral load transfer between front and rear axles depends on both roll stiffness and suspension geometry.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper uses computer simulation to examine the influence of lateral load transfer distribution on directional response. The simulation indicates that in mid-range maneuvers, say from .4g to .6g on a dry surface characterized by a friction limit of .85, the distribution of lateral load transfer has significant implications for directional response. This paper illustrates these differences by calculations in the time domain and by tracking peak response variables in ramped steer maneuvers as a function of lateral load transfer distribution. Differences are also apparent in the limit range where the distribution of lateral load transfer is shown to be very influential, differentiating in some cases between spin out and plow out response.&lt;/div&gt;