gebhart/patrepeval huggingface dataset:
Feather Meal: A Previously Unrecognized Route for Reentry into the Food Supply of Multiple Pharmaceuticals and Personal Care Products (PPCPs) (2012)

Antimicrobials used in poultry production have the potential to bioaccumulate in poultry feathers but available data are scarce. Following poultry slaughter, feathers are converted by rendering into feather meal and sold as fertilizer and animal feed, thereby providing a potential pathway for reentry of drugs into the human food supply. We analyzed feather meal (n = 12 samples) for 59 pharmaceuticals and personal care products (PPCPs) using EPA method 1694 employing liquid chromatography tandem mass spectrometry (LC/MS/MS). All samples tested positive and six classes of antimicrobials were detected, with a range of two to ten antimicrobials per sample. Caffeine and acetaminophen were detected in 10 of 12 samples. A number of PPCPs were determined to be heat labile during laboratory simulation of the rendering process. Growth of wild-type E. coli in MacConkey agar was inhibited by sterilized feather meal (p = 0.01) and by the antimicrobial enrofloxacin (p < 0.0001) at levels found in feather meal. Growth of a drug-resistant E. coli strain was not inhibited by sterilized feather meal or enrofloxacin. This is the first study to detect antimicrobial residues in feather meal. Initial results suggest that more studies are needed to better understand potential risks posed to consumers by drug residues in feather meal.
P3–072: Mild cognitive impairment – the danger of basing the diagnosis on published normative groups (2006)

The value of published neuropsychological normative values has become a recent focus of attention, since many researchers want to define MCI in terms of 1.0 s.d. or 1.5 s.d. below means for published normal controls on standardized neuropsychological tests. The most widely used tests and batteries (WAIS, WMS–R, Boston Naming Test) acquired population norms from large mixed American populations with varying educational background. But how closely do these published norms reflect the reality in the local urban elderly multicultural population of Montreal, Canada who are assessed in our Memory Clinic? To evaluate the local normative population, and assess to what degree MCI based on their values would differ from MCI based on published norms. We carried out a slightly modified neuropsychological battery in 118 volunteer community subjects screened by a physician and judged to be neuropsychologically normal. We compared their results with published norms. A cohort of 60 patients judged as meeting criteria for MCI clinically were evaluated against both sets of normative stimuli. Our normal control group deviates significantly from published norms for virtually all tests utilized. Minor variation in technique (eg, we do the Logical Memory with one story and double the score) was perhaps contributive to one score difference. Almost all our normal controls exceeded published norms on construction and executive function tasks, sometimes by several standard deviations. Results on BNT were lower than published norms. These results are explained by cultural and educational factors such as multilingualism. The overall impact was that the degree of short term memory loss in our MCI cohort was much greater (mean 1.8 SD vs. 1.1 SD) when local normals were utilized. Furthermore, most were judged as multiple domain involvement rather than strictly amnestic loss when local norms were used. The sum effect is that published norms may be substantially different from the local community base. It is proposed that normative means and standard deviations may need to be checked locally before coherence with published norms is assumed. Basing a diagnosis of MCI on published norms (rather than clinical evaluation) will underestimate the impairment of many MCI patients.
Ultrastructure of an arterial lesion induced in rats by fenoldopam mesylate, a dopaminergic vasodilator. (1989)

Fenoldopam mesylate (FM) is a dopaminergic vasodilator with demonstrated efficacy and a favourable safety profile in hypertensive and congestive heart failure patients. FM produced a novel arterial lesion in renal and splanchnic arteries of rats, but not dogs or monkeys. The studies reported here were undertaken to investigate the ultrastructure of the arterial lesion induced in rats by FM in an attempt to shed light on its pathogenesis. Rats were infused intravenously with FM, either 50 micrograms/kg/min for 1 or 4 h, or 5 or 100 micrograms/kg/min for 24 h. Control rats were infused for 4 or 24 h with vehicle alone. Perfusion-fixed tissue from the stomach and pancreas of control and drug-treated rats was examined by transmission electron microscopy. No arterial lesions were seen in rats infused with the drug for 1 or 4 h, or in control rats. All drug-treated rats infused with 5 or 100 micrograms/kg/min of FM for 24 h had lesions in subserosal gastric arteries and interlobular pancreatic arteries. In areas of mild arterial damage, medial smooth muscle cells contained intracytoplasmic pseudovacuoles, autophagic vacuoles, and electron-dense, myofilamentous inclusions. More severe lesions were characterized by overt medial necrosis and haemorrhage. The endothelium of affected arteries was invariably intact, except in areas of severe medial damage. The internal elastic lamina and connective tissue elements within the arterial wall were unaffected. These findings suggest that medial smooth muscle cells are the primary site of damage caused by fenoldopam mesylate in splanchnic arteries of the rat. This iatrogenic arterial lesion could provide an interesting model to study the response of medial smooth muscle to pharmacologically mediated injury.
OBSERVATION AND MODEDELLING OF UFORMANTU TRANSITIONS USING ISASS (An Interactive Speech Analysis-Synthesis System) (1980)

The rules for vocalic sound transitions usually consider a limited frequency range for each forrnant. Current acoustic knowledge of speech production allows us to give a different interpretation of vocalic sound transitions. This interpretation would explain the existence of the so— called 'spurious formants, the observed asyn— chrony between transitions, and the effects of coarticulation across consonants. We show as an example that the second forniant of 1w! is transformed through the transition into the fourth formant of lu in the sequence /wi/; a result implied in K.N. STEVENS theoretical model (1). Implications for automatic speech pattern discrimination and synthesis are discussed.
Highly sensitive nanoparticle-based multifunctional biosensor for antigen detection (2011)

Precise and selective positioning of nanoparticles gives rise to many applications where assembly of nano building blocks with different biological or chemical functionalization is necessary. One remarkable application is the simultaneous early detection of multiple biomarkers in the field of miniaturized multiplex biosensors. To enable multiplex detection of antigens, nanoparticles with various antibody coatings can be selectively assembled in trenches on different regions on a biochip so that they bind selectively to the specific antigen of interest. The presented work utilizes electric field assisted assembly techniques to assemble nanoparticles with various surface functionalization and coatings. Nanoparticles are assembled into pre-fabricated via and trench patterns generated on a PMMA coated gold surface, using electron-beam lithography. Two techniques have been developed for selective assembly of nanoparticles: sequential size-selective directed assembly and sequential site-selective assembly. Both selective assembly techniques provide fast and reproducible assembly over large areas while achieving high yield. The sequential size-selective assembly is a template-assisted technique where the selectivity is achieved by controlling the size of the nanopatterns and the size of the nanoparticles. The possibility of particle detachment and the factors affecting the sorting efficiency for this technique is studied. We show that a complete sorting can be achieved when the size of the vias is close to the diameter of the nanoparticles and the size distribution of the chosen nanoparticles do not overlap. In the site-selective assembly, the selectivity is achieved by having electrically isolated sites (regions) on the same chip. Electrophoresis is performed for each region in a step by step process. Selective assembly results, for up to four nanoparticles with various coating/functionalization are presented using the site-selective assembly technique. We use the electrophoresis technique to assemble the cancer specific anti-PSA, mAb-2C5 and CEA coated nanoparticles to show that the nanoparticle-based biochip can successfully measure low concentrations of various antigen. The principle of operation of these biosensors is the fluorescence based ELISA. Testing results of the nanoparticle-based biochips indicate very high specificity and the detection limit 200 times smaller than the commercially available devices for antigen detection, laying the foundation for early detection of various diseases. The optimized assembly of antibody coated particles and selective assembly techniques introduced in this work provide the necessary tools for fabricating a miniaturized nanoparticle-based in-vivo multiplex biosensor. The antigen detection results show the great potential for early detection of various diseases using the fabricated in-vivo device.
Service Function Chaining and Embedding With Heterogeneous Faults Tolerance in Edge Networks (2022)

In the 5G-and-beyond era, ultra-reliable low latency communication (URLLC) services are ubiquitous in edge networks. To enhance the performance metrics and the quality of service (QoS), URLLC services are delivered via a sequence of software-based network functions, also known as a service function chain (SFC). Towards reliable SFC delivery, it is imperative to incorporate fault-tolerance during SFC deployments. However, deploying an SFC with fault-tolerance is challenging because the protection mechanism needs to jointly consider multiple concurrent physical/virtual network failures and hardware/software failures. Considering these concurrent heterogeneous failures, this work investigates how to effectively deliver an SFC in edge networks with the objective of minimizing bandwidth resource consumption. First, we introduce the concept of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -heterogeneous-faults-tolerance and propose an augmented protection graph, called <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -connected service function slices layered graph (KC-SLG). Based on the KC-SLG, we formulate a novel problem called <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -heterogeneous-faults-tolerant SFC embedding and propose an effective algorithm, called fault-tolerant service function graph embedding (FT-SFGE). FT-SFGE employs two proposed techniques: <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -connected network slicing (KC-NS) and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -connected function slicing (KC-FS). Via thorough mathematical proofs, we show that KC-NS is 2-approximate. Extensive simulations show that KC-FS has the best average cost-efficiency when <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> = 2, and FT-SFGE outperforms the schemes directly extended from the state-of-the-art.
An open-source state-of-the-art toolbox for broadcast news diarization (2013)

This paper presents the LIUM open-source speaker diarization toolbox, mostly dedicated to broadcast news.This tool includes both Hierarchical Agglomerative Clustering using well-known measures such as BIC and CLR, and the new ILP clustering algorithm using i-vectors.Diarization systems are tested on the French evaluation data from ESTER, ETAPE and REPERE campaigns.
Status of VIRGO (2004)

In this paper, we present the status of the VIRGO interferometer, the French-Italian gravitational wave detector. During the last two years the construction of the apparatus has been completed. At the same time, the commissioning of the detector central part, the VIRGO central interferometer, has been used to test all the technical solutions and in particular the most original part: the seismic isolation system. In the next few months the commissioning of the whole detector will start with the alignment and the locking of one of the two 3 km long Fabry-Perot cavities.
Low-noise THz-wave generation from a dual-wavelength fiber Brillouin cavity coupled to a UTC-photodiode (2019)

A dual-wavelength photonic system for carrier-frequency-stable THz signal generation is demonstrated. An in-loop fractional frequency instability &lt;10−16 via synchronization to an external reference while preserving the intrinsic low phase noise of a Brillouin cavity is experimentally demonstrated.
Control of Pickering emulsion properties by the structural characteristics of nanocelluloses (2018)

International audience
Graph Partitioning and Sparse Matrix Ordering using Reinforcement Learning and Graph Neural Networks (2021)

We present a novel method for graph partitioning, based on reinforcement learning and graph convolutional neural networks. Our approach is to recursively partition coarser representations of a given graph. The neural network is implemented using SAGE graph convolution layers, and trained using an advantage actor critic (A2C) agent. We present two variants, one for finding an edge separator that minimizes the normalized cut or quotient cut, and one that finds a small vertex separator. The vertex separators are then used to construct a nested dissection ordering to permute a sparse matrix so that its triangular factorization will incur less fill-in. The partitioning quality is compared with partitions obtained using METIS and SCOTCH, and the nested dissection ordering is evaluated in the sparse solver SuperLU. Our results show that the proposed method achieves similar partitioning quality as METIS and SCOTCH. Furthermore, the method generalizes across different classes of graphs, and works well on a variety of graphs from the SuiteSparse sparse matrix collection.
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice (2004)

Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is known to be involved in various cellular processes, such as DNA repair, genomic stability, transcription, and cell death. During apoptosis, PARP-1 is cleaved by caspases to generate 89-kDa and 24-kDa fragments, a hallmark of apoptosis. This cleavage is thought to be a regulatory event for cellular death. In order to understand the biological significance of PARP-1 cleavage, we generated a PARP-1 knockin (PARP-1(KI/KI)) mouse model, in which the caspase cleavage site of PARP-1, DEVD(214), was mutated to render the protein resistant to caspases during apoptosis. While PARP-1(KI/KI) mice developed normally, they were highly resistant to endotoxic shock and to intestinal and renal ischemia-reperfusions, which were associated with reduced inflammatory responses in the target tissues and cells due to the compromised production of specific inflammatory mediators. Despite normal binding of NF-kappaB to DNA, NF-kappaB-mediated transcription activity was impaired in the presence of caspase-resistant PARP-1. This study provides a novel insight into the function of PARP-1 in inflammation and ischemia-related pathophysiologies.
Erweitertes Optimierungsverfahren für den Spritzgießprozess (2001)

Abstract Zur Prozessoptimierung beim Spritzgießen wird ein Betriebspunkt bestimmt, an dem vorgegebene Eigenschaften der Teile eingehalten werden und der Prozess unempfindlich gegen Störungen ist. Das vorgestellte Optimierungskonzept basiert auf Antwortflächen, welche durch Scattered Data Interpolation Methoden erzeugt werden. Probleme die im Zusammenhang mit der Wahl des geeigneten Interpolationsmodells auftreten werden diskutiert.
Solving the protein sequence metric problem (2005)

Biological sequences are composed of long strings of alphabetic letters rather than arrays of numerical values. Lack of a natural underlying metric for comparing such alphabetic data significantly inhibits sophisticated statistical analyses of sequences, modeling structural and functional aspects of proteins, and related problems. Herein, we use multivariate statistical analyses on almost 500 amino acid attributes to produce a small set of highly interpretable numeric patterns of amino acid variability. These high-dimensional attribute data are summarized by five multidimensional patterns of attribute covariation that reflect polarity, secondary structure, molecular volume, codon diversity, and electrostatic charge. Numerical scores for each amino acid then transform amino acid sequences for statistical analyses. Relationships between transformed data and amino acid substitution matrices show significant associations for polarity and codon diversity scores. Transformed alphabetic data are used in analysis of variance and discriminant analysis to study DNA binding in the basic helix-loop-helix proteins. The transformed scores offer a general solution for analyzing a wide variety of sequence analysis problems.
Use of System Peaks in Liquid Chromatography for Continuous Online Monitoring of Chemical Reactions (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of System Peaks in Liquid Chromatography for Continuous Online Monitoring of Chemical ReactionsNira. Mizrotsky and Eli. GrushkaCite this: Anal. Chem. 1995, 67, 10, 1737–1741Publication Date (Print):May 15, 1995Publication History Published online1 May 2002Published inissue 15 May 1995https://pubs.acs.org/doi/10.1021/ac00106a014https://doi.org/10.1021/ac00106a014research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interferometric phase measurement with two-photon states (2009)

We demonstrate experimentally a phase measurement using general two-photon superposition states in a multiport interferometer shown schematically. A pair of photons, produced in the process of spontaneous parametric down-conversion, is transformed into the desired superposition state using beam splitters BS1 and BS2, provided that no photon escapes through the unmonitored port of BS2. In the signal arm, the photon pair experiences losses introduced by the beam splitter BS3 and monitored by a detector C, and subsequently probes the phase shift phi. The phase information is read out by sending the photons onto the beam splitter BS4, whose output ports are monitored by detectors A and B.
Bandgap Engineering in High-Efficiency Multijunction Concentrator Cells (2005)

This paper discusses semiconductor device research paths under investigation with the aim of reaching the milestone efficiency of 40%. A cost analysis shows that achieving very high cell efficiencies is crucial for the realization of cost-effective photovoltaics, because of the strongly leveraging effect of efficiency on module packaging and balance-of systems costs. Lattice-matched (LM) GaInP / GaInAs / Ge 3-junction cells have achieved the highest independently confirmed efficiency at 175 suns, 25°C, of 37.3 % under the standard AM1.5D, low-AOD terrestrial spectrum. Lattice-mismatched, or metamorphic (MM), materials offer still higher potential efficiencies, if the crystal quality can be maintained. Theoretical efficiencies well over 50 % are possible for a MM GaInP / 1.17-eV GaInAs / Ge 3-junction cell limited by radiative recombination at 500 suns. The bandgap – open circuit voltage offset, (Eg/q) – Voc, is used as a valuable theoretical and experimental tool to characterize multijunction cells with subcell bandgaps ranging from 0.7 to 2.1 eV. Experimental results are presented for prototype 6-junction cells employing an active ~1.1-eV dilute nitride GaInNAs subcell, with active-area efficiency greater than 23 % and over 5.3 V open-circuit voltage under the 1-sun AM0 space spectrum. Such cell designs have theoretical efficiencies under the terrestrial spectrum at 500 suns concentration exceeding 55 % efficiency, even for lattice-matched designs. 1.
Ocular Neovascularization Caused by Herpes Simplex Virus Type 1 Infection Results from Breakdown of Binding between Vascular Endothelial Growth Factor A and Its Soluble Receptor (2011)

Abstract The normal cornea is transparent, which is essential for normal vision, and although the angiogenic factor vascular endothelial growth factor A (VEGF-A) is present in the cornea, its angiogenic activity is impeded by being bound to a soluble form of the VEGF receptor-1 (sVR-1). This report investigates the effect on the balance between VEGF-A and sVR-1 that occurs after ocular infection with HSV, which causes prominent neovascularization, an essential step in the pathogenesis of the vision-impairing lesion, stromal keratitis. We demonstrate that HSV-1 infection causes increased production of VEGF-A but reduces sVR-1 levels, resulting in an imbalance of VEGF-A and sVR-1 levels in ocular tissues. Moreover, the sVR-1 protein made was degraded by the metalloproteinase (MMP) enzymes MMP-2, -7, and -9 produced by infiltrating inflammatory cells that were principally neutrophils. Inhibition of neutrophils, inhibition of sVR-1 breakdown with the MMP inhibitor marimastat, and the provision of exogenous recombinant sVR-1 protein all resulted in reduced angiogenesis. Our results make the novel observation that ocular neovascularization resulting from HSV infection involves a change in the balance between VEGF-A and its soluble inhibitory receptor. Future therapies aimed to increase the production and activity of sVR-1 protein could benefit the management of stromal keratitis, an important cause of human blindness.