gebhart/patrepeval huggingface dataset:
Hepatotoxicidad y senescencia. Parámetros estructurales y funcionales relacionados con el estrés oxidativo en hepatocitos de rata (1996)

La destruccion selectiva de los hepatocitos centrilobulares producida por una dosis subletal de tioacetamida y el estado proliferativo del higado en regeneracion que sigue inmediatamente a la necrosis, se han utilizado como modelo para estudiar las variaciones en la respuesta hepatica a lo largo de la edad frente a la agresion de un agente toxico. Para ello, el periodo de vida elegido en ratas macho wistar abarca desde los 2 hasta los 30 meses (2 anos y medio). Se han realizado estudios morfologicos determinantes del grado de lesion, relacionados con el ciclo redox del glutation e implicados en el proceso proliferativo del higado. De los resultados obtenidos se deduce que en la senescencia se produce una disminucion en la eliminacion de xenobioticos y un retraso en la regeneracion hepato-celular y la restauracion de su funcionalidad. Por ello, la conclusion a nivel clinico y farmacologico es que las dosis de farmacos administrados a pacientes en edad avanzada han de ser cuidadosamente controladas por presentar estos una mayor susceptibilidad a situaciones de estres oxidativo
One‐Step Photochemical Green Synthesis of Water‐Dispersible Ag, Au, and Au@Ag Core–Shell Nanoparticles (2019)

A simple and green synthetic protocol for the rapid and effective preparation of Ag, Au and Au@Ag core-shell nanoparticles (NPs) is reported based on the light irradiation of a biocompatible, water-soluble dextran functionalized with benzophenone (BP) in the presence of AgNO<sub>3</sub> , HAuCl<sub>4</sub> , or both. Photoactivation of the BP moiety produces the highly reducing ketyl radicals through fast (<50 ns) intramolecular H-abstraction from the dextran scaffold, which, in turn, ensures excellent dispersibility of the obtained metal NPs in water. The antibacterial activity of the AgNPs and the photothermal action of the Au@Ag core-shell are also shown.
Animal Models in AIDS Research (2021)

This chapter summarizes the knowledge gained from various animal models, particularly primate models, due to their genetic and physiologic similarities to humans and their general usefulness in planning human clinical trials of human immunodeficiency virus (HIV) vaccines and therapeutic strategies. An ideal animal model for HIV/Acquired immunodeficiency syndrome (AIDS) in humans would involve HIV or a close relative, such that the host range, tissue distribution, disease progression, and route of infection are similar, if not identical. Experimentally, rabbits can be infected with bovine immunodeficiency virus, and some studies have attempted to establish the BIV-infected rabbit as a useful animal model for HIV/AIDS. Of all the animal models explored for studies related to HIV/AIDS in humans, the SIV-infected monkey model has proven the most useful for understanding various aspects of HIV pathobiology and immunology. Most of the prime-and-boost modalities tested for vaccination against HIV in the nonhuman primate model used HIV structural proteins.
Disorder and polymorphism in Cu(ii)-polyoxometalate complexes: [Cu1.5(H2O)7.5PW12O40]·4.75H2O, cis- & trans-[Cu2(H2O)10SiW12O40]·6H2O (2016)

Three highly crystalline Cu(<sc>ii</sc>)-polyoxometalate (POM) complexes, [Cu<sub>1.5</sub>(H<sub>2</sub>O)<sub>7.5</sub>PW<sub>12</sub>O<sub>40</sub>]·4.75H<sub>2</sub>O and <italic>cis</italic>- and <italic>trans</italic>-[Cu<sub>2</sub>(H<sub>2</sub>O)<sub>10</sub>SiW<sub>12</sub>O<sub>40</sub>]·6H<sub>2</sub>O, were successfully synthesized and characterized by single crystal and powder X-ray diffraction as well as thermogravimetric analysis.
Intramolecular generation and rearrangement of ammonium ylides from copper carbenoids: a general method for the synthesis of cyclic amines (1994)

J. S. Clark and P. B. Hodgson, J. Chem. Soc., Chem. Commun., 1994, 2701 DOI: 10.1039/C39940002701
Uncertainty and Variability in Point Cloud Surface Data (2004)

We present a framework for analyzing shape uncertainty and variability in point-sampled geometry. Our representation is mainly targeted towards discrete surface data stemming from 3D acquisition devices, where a finite number of possibly noisy samples provides only incomplete information about the underlying surface. We capture this uncertainty by introducing a statistical representation that quantifies for each point in space the likelihood that a surface fitting the data passes through that point. This likelihood map is constructed by aggregating local linear extrapolators computed from weighted least squares fits. The quality of fit of these extrapolators is combined into a corresponding confidence map that measures the quality of local tangent estimates. We present an analysis of the effect of noise on these maps, show how to efficiently compute them, and extend the basic definition to a scale-space formulation. Various applications of our framework are discussed, including an adaptive re-sampling method, an algorithm for reconstructing surfaces in the presence of noise, and a technique for robustly merging a set of scans into a single point-based representation.
Adult Burkitt lymphoma: advances in diagnosis and treatment. (2008)

Burkitt lymphoma is a unique B-cell malignancy with a high proliferation rate and characteristic genetic changes involving the c-myc oncogene. Burkitt lymphoma is common in children but also occurs in adults, where distinction from diffuse large B-cell lymphoma may pose a problem. The development of brief, very intensive chemotherapy regimens has led to a very high cure rate in children with Burkitt lymphoma. The use of these regimens in adults, often in combination with the antibody rituximab (Rituxan), has also made the cure of a majority of adults possible. Burkitt lymphoma in adults cannot be treated effectively with the common regimens used for diffuse large B-cell lymphoma such as CHOP-R (cyclophosphamide, doxorubicin HCl, vincristine [Oncovin], prednisone, rituximab). Prompt diagnosis and initiation of appropriate therapy with attention to the possibility of tumor lysis syndrome are necessary for optimal results.
An iterative method for optical reconstruction of graded index profiles in planar dielectric waveguides (2000)

A nondestructive technique for the reconstruction of refractive index profiles in planar waveguides is presented and analyzed. The approach is based on the integral scattering equations, which permit one to relate the refractive index of an inhomogeneous layer to the reflected field intensity at different incidence angles. From this formulation, an iterative algorithm is developed, such as at each iteration step the problem is formulated as the minimization of a functional representing the error between the measurements and the model data. The recovered profile is then used to improve the validity of the approximation in performing the next step. In this approach, the unknown index profile is represented as the sum of a finite series of basis functions avoiding to select a priori the particular functional form (e.g., Gaussian function, complementary error function, etc). The practical effectiveness of this approach is demonstrated by numerically simulating the measurements for different planar waveguides. The influence of measurement uncertainty and noise on the stability of the technique is also evaluated.
Multiple Lyapunov Function Based Reaching Condition for Orbital Existence of Switching Power Converters (2008)

A methodology to analyze the reaching condition of a switching power converter (SPC) using Lyapunov's direct method and a piecewise linear model is outlined. By using a multiple Lyapunov function, the reaching criteria for orbital existence of a SPC is formulated as a linear matrix inequality that is solved using a convex optimization solver. Further, the criterion is modified to distinguish the different modes (i.e., sliding and asymptotic modes and combination of the two fundamental modes) of convergences of the reaching dynamics. The applicability of the reaching criteria for solving practical problems using case illustrations of dc-dc converters and three-phase dc-ac converters operating with different control and modulation techniques is demonstrated. The methodology developed in this paper can be potentially extended to other SPCs and may lead to the development of optimal-sequence control techniques that can dynamically change the mode and the rate of convergence of a SPC.
Electrically driven terahertz radiation of 2DEG plasmons in AlGaN/GaN structures at 110 K temperature (2017)

We experimentally observed a terahertz (THz) radiation of electrically driven 2D electron gas (2DEG) plasmons in AlGaN/AlN/GaN structures at T = 110 K. The grating with a period of 1.0 μm and a filling factor of 0.35 was used to couple electromagnetic radiation out from the plasmonic sample excited in a pulsed regime. The peak power radiated from ungated 2DEG plasmons at a frequency of 5.0 THz under an electric field of 450 V/cm was up to 940 nW. The intensity of the radiation was sufficient to measure spectra with a conventional far-infrared Fourier transform spectrometer. The analysis of the data revealed that the 2DEG plasmon radiation was superimposed with the black-body radiation of the sample and electroluminescence of the impurities. The strategy to reach higher powers of THz emission for practical applications is discussed.
Geotechnical Analysis of Paleoseismic Shaking Using Liquefaction Features: Part I. Major Updating of Analysis Techniques (2003)

A new methodology is proposed for the geotechnical analysis of strength of paleoseismic shaking using liquefaction effects. The proposed method provides recommendations for selection of both individual and regionally located test sites, techniques for validation of field data for use in back-analysis, and use of a recently developed energy-based solution to back-calculate paleoearthquake magnitude and strength of shaking. The proposed method allows investigators to assess the influence of post-earthquake density change and aging. The proposed method also describes how the back-calculations from individual sites should be integrated into a regional assessment of paleoseismic parameters.
Androgenetic Alopecia in the Female (1994)

Topical minoxidil was significantly more effective than placebo in the treatment of female androgenetic alopecia.
Data from DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway (2023)

&lt;div&gt;Abstract&lt;p&gt;Cancer stem cell (CSC) marker doublecortin-like kinase 1 (DCLK1) contributes greatly to the malignancy of gastrointestinal cancers, and DCLK1-targeted agents have potential therapeutic value. However, the molecular pathways regulated by DCLK1-S (DCLK1 isoform 4), a shortened splice variant of DCLK1, still remain obscure. Here we found that the expression of DCLK1-S is significantly increased in human esophageal squamous cell carcinoma (ESCC) tissues and associated with malignant progression and poor prognosis. Functional studies indicated that silencing total of DCLK1 mediated by CRISPR/Cas9 inhibited ESCC cell proliferation, migration, and invasion. Conversely, these changes were largely reversed after DCLK1-S rescue or overexpression. More importantly, DCLK1-S significantly enhanced primary tumor formation and metastatic lung colonization &lt;i&gt;in vivo&lt;/i&gt;. The Cancer Genome Atlas database and molecular analysis showed that DCLK1-S was closely related to the epithelial–mesenchymal transition (EMT) process in patients with ESCC. Further RNA sequencing and Kyoto Encyclopedia of Genes and Genomes analysis demonstrated that MAPK signaling pathway was significantly enriched. Our &lt;i&gt;in vitro&lt;/i&gt; study proclaimed that DCLK1-S induced MMP2 expression in ESCC cells via MAPK/ERK signaling, leading to the activation of EMT. In addition, administration of ERK1/2 blocker SCH772984 attenuated the proliferative and migratory phenotype induced by DCLK1-S. In conclusion, these findings suggest that DCLK1-S may be a key molecule in MAPK/ERK/MMP2 pathway–mediated progression of ESCC, and that it has potential as a biomarker or therapeutic target to improve outcomes in patients with ESCC.&lt;/p&gt;Implications&lt;p&gt;: DCLK1-S induces ESCC progression by activating the MAPK/ERK/MMP2 axis and may serve as a prognostic biomarker or therapeutic target for patients with ESCC.&lt;/p&gt;&lt;/div&gt;
SIGNAL-MEDIATED SORTING OF MEMBRANE PROTEINS BETWEEN THE ENDOPLASMIC RETICULUM AND THE GOLGI APPARATUS (1996)

Each organelle of the secretory pathway is required to selectively allow transit of newly synthesized secretory and plasma membrane proteins and also to maintain a unique set of resident proteins that define its structural and functional properties. In the case of the endoplasmic reticulum (ER), residency is achieved in two ways: (a) prevention of residents from entering newly forming transport vesicles and (b) retrieval of those residents that escape. The latter mechanism is directed by discrete retrieval motifs: Soluble proteins have a H/KDEL sequence at their carboxy-terminus; membrane proteins have a dibasic motif, either di-lysine or di-arginine, located close to the terminus of their cytoplasmic domain. Recently it was found that di-lysine motifs bind the complex of cytosolic coat proteins, COP I, and that this interaction functions in the retrieval of proteins from the Golgi to the ER. Also discussed are the potential roles this interaction may have in vesicular trafficking.
Cover Picture: Ultrathin Magnesium Metal Anode – An Essential Component for High‐Energy‐Density Magnesium Battery Materialization (Batteries & Supercaps 9/2022) (2022)

The Front Cover illustrates the rechargeable magnesium batteries incorporating ultrathin magnesium metal foils as an anode with the energy densities of 72 Wh kg−1 based on the weight of cathodes and anodes. More information can be found in the Research Article by T. Mandai, H. Somekawa.
Office form definition and processing using a relational data model (1984)

Office forms have a particular structure and semantics that make them a suitable communication medium. The Natural Forms Query Language, NFQL, capitalizes on these features of ordinary forms to provide a communication language between human beings and the computer. Given a form, NFQL analyzes it to deduce plausible interpretations and then generates database queries and function specifications applicable to the form. This paper explains how NFQL recognizes computational relationships between arguments and results and formulates function specifications. General rules are given, in terms of a relational data model, that can resolve computational relationships for ordinary forms.
Electrophysiological Effects of Monophasic and Biphasic Stimuli in Normal and Infarcted Dogs (1990)

Though some biphasic waveforms significantly decrease the energy required for defibrillation, little is known about the effect of biphasic stimulation on the determination of other electrophysiological parameters in normal and infarcted hearts. To evaluate this, nine normal dogs and 12 dogs with myocardial infarction had activation threshold (AT), effective refractory period (ERP), strength-interval curves, and ventricular fibrillation threshold (VFT) determined with constant current stimulation to a pair of right ventricular plunge electrodes, and upper limit of vulnerability (ULV) and defibrillation threshold (DFT) determined with truncated exponential shocks delivered to a pair of wire electrodes coiled to contour the right and left ventricular epicardium. Each electrophysiological parameter was determined with a 5.5 msec monophasic and 5.5-msec biphasic (3.5 msec first phase) waveform. Though AT and VFT were not significantly different for the two waveforms, the ERP was significantly longer, the strength-interval curve shifted rightward, and the threshold for repetitive responses higher for biphasic stimuli. Compared to the monophasic waveform, the ULV and DFT were significantly decreased in a parallel fashion for the biphasic waveform. Neither the presence nor size of myocardial infarction significantly affected any of the measured electrophysiological parameters. In six additional dogs, sigmoid defibrillation probability curves were constructed from biphasic shocks of four energies including that of the DFT and ULV. The ULV energy predicted an effective dose that defibrillated 97% of the time (range 90%-100%). In conclusion, the increased defibrillation efficacy of the biphasic waveform is independent of its ability to activate fully repolarized myocardium and cannot be explained by a greater ability of biphasic waveforms to activate partially depolarized tissue. The parallel decrease in the ULV and DFT for biphasic stimulation and the finding that the ULV energy defibrillates with a high probability of success suggest similar underlying mechanisms for the ULV and defibrillation.
Sulfonation of unsaturated compounds. I. Sulfonation of branched chain ketones with sulfur trioxide. One-step synthesis of tetramethylene sulfate through a retro pinacol-type) rearrangement (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfonation of unsaturated compounds. I. Sulfonation of branched chain ketones with sulfur trioxide. One-step synthesis of tetramethylene sulfate through a retro pinacol-type) rearrangementJohn C. Sheehan and Uri ZollerCite this: J. Org. Chem. 1974, 39, 23, 3415–3416Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jo00937a025https://doi.org/10.1021/jo00937a025research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of metal stearate antacid on the melt stabilization performance of phenolic/phosphite antioxidants in metallocene LLDPE. Part 1: Melt processing stability (2004)

Abstract The influence of metal stearates on the melt stabilization performance of combinations of phenolic and phosphite antioxidants in a metallocene LLDPE (mLLDPE) has been investigated. This study focused on the effect of both the origin of the stearine blend (i.e., vegetable or animal) used in the formation of the metal stearates and the type of metal stearate (i.e., calcium and zinc stearate). A multiple extrusion experiment was carried out and melt stabilization performance was monitored by melt flow rate (MFR) measurements. The level of consumption of antioxidants was evaluated by HPLC analysis of solvent extracts. Although antagonism was observed with all formulations containing metal stearates, a noticeably greater detrimental effect was apparent with metal stearates based on the vegetable derived stearine blend. Furthermore, it was apparent that the vegetable zinc stearate had a greater detrimental effect than the calcium stearate equivalent. The presence of impurities such as peroxides and metal oxides in the metal stearates investigated was believed to account for the antagonism observed. J. Vinyl Addit. Technol. 10:137–143, 2004. © 2004 Society of Plastics Engineers.
Pathophysiological Role of Magnesium in Familial Bartter's Syndrome. (1994)

We studied three siblings with Bartter's syndrome associated with hypomagnesemia; two of them showing marked hypomagnesemia and the other mild hypomagnesemia. Urinary potassium, sodium and chloride excretions were determined and distal fractional chloride reabsorption and free water clearance on water loading test were compared before and after magnesium supplementation. Baseline urinary potassium and magnesium excretions were elevated in spite of the decreased plasma levels, whereas distal fractional chloride reabsorption and free water clearance were depressed in all patients. Magnesium repletion resulted in significant decrease in urinary potassium, sodium and chloride and subsequent increase in plasma potassium in all patients. However, neither distal fractional chloride reabsorption nor free water clearance was affected. Hypomagnesemia may contribute to urinary potassium wasting and aggravate urinary sodium and chloride wasting in familial Bartter's syndrome by a mechanism independent of the defect in free-water formation by the active reabsorption of chloride in Henle's loop.
Off-stoichiometric silver antimony telluride: An experimental study of transport properties with intrinsic and extrinsic doping (2015)

AgSbTe2 is a thermoelectric semiconductor with an intrinsically low thermal conductivity and a valence band structure that is favorable to obtaining a high thermoelectric figure of merit zT. It also has a very small energy gap Eg ∼ 7.6 ± 3 meV. As this gap is less than the thermal excitation energy at room temperature, near-intrinsic AgSbTe2 is a two carrier system having both holes (concentration p) and electrons (n). Good thermoelectric performance requires heavy p-type doping (p &amp;gt; &amp;gt; n). This can be achieved with native defects or with extrinsic doping, e.g. with transition metal element. The use of defect doping is complicated by the fact that many of the ternary Ag-Sb-Te and pseudo-binary Sb2Te3-Ag2Te phase diagrams are contradictory. This paper determines the compositional region most favorable to creating a single phase material. Through a combination of intrinsic and extrinsic doping, values of zT &amp;gt; 1 are achieved, though not on single-phased material. Additionally, we show that thermal conductivity is not affected by defects, further demonstrating that the low lattice thermal conductivity of I-V-VI2 materials is due to an intrinsic mechanism, insensitive to changes in defect structure.
1H NMR Studies of Alginate Interactions with Amino Acids (2003)

The interactions between alginate and the amino acids, histidine, lysine, phenylalanine, and alanine, were studied by Proton Nuclear Magnetic Resonance. The characterization of the amino acids interaction with alginate was performed by 1D and 2D-NOESY experiments. Measurements of 1 H NMR nonselective and selective relaxation rates in the absence and presence of alginate were used to calculate interaction constants between each amino acid and alginate. The interaction constants were found to be related to the hydrophobicity of the different amino acid side-chains. The interaction constant between phenylalanine and Ca 2+ crosslinked alginate was also determined. There was no apparent differences observed in the crosslinked and the solution amino acid-alginate interactions. On the basis of the experimental results obtained, a model of the interaction between amino acids and alginate was proposed.