gebhart/patrepeval huggingface dataset:
A Cloud Native SLA-Driven Stochastic Federated Learning Policy for 6G Zero-Touch Network Slicing (2022)

eration (6G)-enabled massive network slicing is a strong enabler for the expected pervasive digitalization of the vertical market. In such a context, artificial intelligence (AI)-driven zero-touch network automation should present a high degree of scalability and sustainability, especially when deployed in live production networks wherein the collected monitoring datasets at different points are non-independent and identically distributed (non-IID). This paper presents a new cloud-native service-level agreement (SLA)-driven stochastic policy to guarantee a scalable and fast operation of constrained federated learning (FL)-based analytic engines that perform statistical slice- level resource provisioning at RAN-Edge in a non-IID setup. Both simulated and cloud-native emulated scenarios are implemented to demonstrate the superiority of the solution in reducing SLA violation, convergence time and computation cost compared to different FL baselines, showcasing thereby a higher scalability.
Fabrication and Characterization of a Vacuum Encapsulated Curved Beam Switch for Harsh Environment Application (2014)

A vacuum-encapsulated silicon switch with a curved electrode is characterized for operation in harsh environments. An ultraclean vacuum encapsulation process (episeal) seals the switch after release, providing a pristine operating environment for switching operations. In these devices, the curved beam of the actuator enhances the overdrive voltage tolerance to be more than 100 V. The ON/OFF cycle tests were carried out up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> cycles at room temperature, and at least 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> cycles under an elevated temperature of 300°C. Throughout the 300°C tests, an average contact resistance of ~ 28 kΩ is measured, demonstrating the stability of the contact. Finally, high speed pulse I-V monitoring unit was used to observe 13-μs switching speed.
<title>Single-channel phase-tracker for the open-loop fiber optic gyroscope</title> (1992)

The present, simplified analog signal-processing technique for an open-loop FOG is based on Kersey and Moeller's (1990) closed-loop phase-shift-nulling concept. This approach emulates the operation of a true closed-loop gyroscope on the basis of low-cost phase tracking, and furnishes a linear output from an open-loop gyro configuration over a +/- 2-pi radian range in Sagnac phase shift. Good linearity and comparatively low noise and drift characteristics are obtained.
Lightweight Attention Convolutional Neural Network for Retinal Vessel Image Segmentation (2020)

Retinal vessel image is an important biological information that can be used for personal identification in the social security domain, and for disease diagnosis in the medical domain. While automatic vessel image segmentation is essential, it is also a challenging task because the retinal vessels have complex topological structures, and the retinal vessels vary in size and shape. In recent years, image segmentation based on the deep learning technique has become a mainstream method. Unfortunately, the existing methods cannot make the best use of the global information, and the model complexity is high. In this article, a convolutional neural network integrated with the attention mechanism is proposed. The overall network structure consists of a basic U-Net and an attention module, and the latter is used to capture global information and to enhance features by placing it in the process of feature fusion. Experiment results on five public datasets show that the proposed scheme outperforms other existing mainstream approaches, and most of the performance indicators are in the leading positions. More importantly, the proposed method has a significant reduction in the number of parameters.
Elevated endothelial microparticle—monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-β1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes (2005)

Monocyte migration through the disrupted cerebral endothelial cell (EC) junctions plays an essential role in formation of multiple sclerosis (MS) demyelinating lesions. During pathogenesis of MS, activated ECs release endothelial microparticles (EMP), which possibly facilitate transendothelial migration (TEMIG) of monocytes. To assess functional roles of EMP in MS, specifically, their (i) interaction with monocytes, (ii) effect on monocyte TEMIG in an in vitro model of the brain microvascular endothelial cells (BMVEC), (iii) phenotypic profiles of EMP elicited by MS plasma and (iv) the effects of IFN-beta 1b on release of EMP and on TEMIG of monocytes (mono) and monocytes:EMP complexes (mono:EMP) through the BMVEC. The effect of IFN-beta 1b on the release of EMP and the TEMIG of mono and mono:EMP was assessed by preincubating BMVEC cultures of IFN-beta 1b prior to addition of plasma. Three EMP phenotypes, CD54, CD62E and CD31 were assayed. Plasma specimens from 20 patients with relapsing remitting MS (11 in exacerbation, MS-E, and 9 in remission, ME-R) and 10 healthy controls were studied. Incubation of BMVEC with MS-E plasma yielded elevated levels of EMPCD54, EMP62E and EMPCD31 relative to MS-R and control plasmas. MS-E but not MS-R or control plasma also augmented TEMIG of monocytes, respectively. Mono:EMP complexes further augmented TEMIG relative to mono alone, but only in the presence of MS-E plasma; there was no significant effect with MS-R or control plasmas. The presence of IFN-beta 1b inhibited TEMIG of mono and mono:EMP by 20% and 30%, respectively. MS-E but not MS-R plasma elicited release of activation-derived EMP and enhanced TEMIG of mono and mono:EMP. IFN-beta 1b inhibited TEMIG and release of EMP, suggesting a role of EMP and a novel therapeutic mechanism for IFN-beta 1b in MS.
Crowdsourced Risk Minimization for Inter-Application Access in Android (2017)

Android's inter-application access enriches its application ecosystem. However, it exposes security vulnerabilities where end-user data can be exploited by attackers. While existing techniques have focused on minimizing the risks of inter-application access, they either suffer from inaccurate risk detection or are primarily available to expert users. This paper introduces a novel technique that automatically analyzes potential risks between a set of applications, aids end-users to effectively assess the identified risks by crowdsourcing assessments, and generates an access control policy which prevents unsafe inter-application access at runtime. Our evaluation demonstrated that our technique identifies potential risks between real-world applications with perfect accuracy, supports a scalable analysis on a large number of applications, and successfully aids end-users' risk assessments.
A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1 (1997)

In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive activity at both levels of mitogen-activated protein kinase (MAPK) and adenylyl cyclase. These activities could be blocked by the CB1-selective ligand, SR 141716A, that functions as an inverse agonist. Moreover, binding studies showed that guanine nucleotides decreased the binding of the agonist CP-55,940, an effect usually observed with agonists, whereas it enhanced the binding of SR 141716A, a property of inverse agonists. Unexpectedly, we found that CB1-mediated effects of SR 141716A included inhibition of MAPK activation by pertussis toxin-sensitive receptor-tyrosine kinase such as insulin or insulin-like growth factor 1 receptors but not by pertussis toxin-insensitive receptor-tyrosine kinase such as the fibroblast growth factor receptor. We also observed similar results when cells were stimulated with Mas-7, a mastoparan analog, that directly activates the Gi protein. Furthermore, SR 141716A inhibited guanosine 5'-0-(thiotriphosphate) uptake induced by CP-55,940 or Mas-7 in CHO-CB1 cell membranes. This indicates that, in addition to the inhibition of autoactivated CB1, SR 141716A can deliver a biological signal that blocks the Gi protein and consequently abrogates most of the Gi-mediated responses. By contrast, SR 141716A had no effect on MAPK activation by insulin or IGF1 in CHO cells lacking CB1 receptors, ruling out the possibility of a direct interaction of SR 141716A with the Gi protein. This supports the notion that the Gi protein may act as a negative intracellular signaling cross-talk molecule. From these original results, which considerably enlarge the biological properties of the inverse agonist, we propose a novel model for receptor/ligand interactions.
A Randomized Trial of Granulocyte-Macrophage Colony-Stimulating Factor in Neonates With Sepsis and Neutropenia (2001)

Treatment with rhGM-CSF is associated with an increase in absolute neutrophil, eosinophil, monocyte, lymphocyte, and platelet counts and decreased mortality in critically ill septic neutropenic neonates. These results suggest that rhGM-CSF may be effective in the treatment of neonatal sepsis with neutropenia, and further randomized trials are needed to confirm its beneficial effects.
A retargetable C compiler : design and implementation (1995)

From the Publisher:
This new text examines the design and implementation of Icc, a production-quality, retargetable compiler, designed at ATT covers compiler theory only as needed to understand the implementation of Icc, focusing instead on practical, applied issues; encourages a deeper understanding of programming in C, by providing C programmers with a tour of the language from the perspective of compiler authors; includes coverage of code generators for the MIPS R3000, SPARC, and Intel 386 and its successors; and provides access to the full source code for the Icc compiler, the three back ends, and the code-generator generator, either on disk or via FTP.
Mini-Review: Novel Therapeutic Strategies to Blunt Actions of Pneumolysin in the Lungs (2013)

Severe pneumonia is the main single cause of death worldwide in children under five years of age. The main etiological agent of pneumonia is the G+ bacterium Streptococcus pneumoniae, which accounts for up to 45% of all cases. Intriguingly, patients can still die days after commencing antibiotic treatment due to the development of permeability edema, although the pathogen was successfully cleared from their lungs. This condition is characterized by a dramatically impaired alveolar epithelial-capillary barrier function and a dysfunction of the sodium transporters required for edema reabsorption, including the apically expressed epithelial sodium channel (ENaC) and the basolaterally expressed sodium potassium pump (Na+-K+-ATPase). The main agent inducing this edema formation is the virulence factor pneumolysin, a cholesterol-binding pore-forming toxin, released in the alveolar compartment of the lungs when pneumococci are being lysed by antibiotic treatment or upon autolysis. Sub-lytic concentrations of pneumolysin can cause endothelial barrier dysfunction and can impair ENaC-mediated sodium uptake in type II alveolar epithelial cells. These events significantly contribute to the formation of permeability edema, for which currently no standard therapy is available. This review focuses on discussing some recent developments in the search for the novel therapeutic agents able to improve lung function despite the presence of pore-forming toxins. Such treatments could reduce the potentially lethal complications occurring after antibiotic treatment of patients with severe pneumonia.
Determination of the Signal-to-Noise Ratio for Noisy Electrocardiogram Using Lossless Data Compression (2019)

A numerical method for determining the signal-to-noise ratio (SNR) in electrocardiograms (ECG), distorted by various types of additive noise, is proposed. It is based on the calculation of the compression ratio (CRn) of an ECG fragment of 10 seconds duration. The functional dependences of SNR on CRn for ECG distorted by electrode motion, muscle artefacts and mixed noise, were found, and they are exponential. The values of root mean square error (RMSE) for such dependencies were 4.24 dB, 3.57 dB ii 3.33 dB accordingly for SNR in range -10...45 dB. It is proved that the inclusion of heart rate (HR) in the model reduces the error by 0.6-0.8 dB. The present approach is based on the standard library zlib and is recommended for use in portative mobile systems.
La chimie des saccharides (2012)

Synthèse de chimie des sucres
Immunoassays (2019)

The present chapter introduces readers to the properties of immunoassays and how smart materials have improved them. The combination of immunoreagents and materials allows us to profit from the advantages of both, yielding smart developments with optimal sensitivity, selectivity, and functionality. Particular achievements are presented and critically discussed.
Remote Spectral Light Sensing in the Home Environment: Further Development of the TWLITE Study Concept (2023)

Aging is a significant contributor to changes in sleep patterns, which has compounding consequences on cognitive health. A modifiable factor contributing to poor sleep is inadequate and/or mistimed light exposure. However, methods to reliably and continuously collect light levels long-term in the home, a necessity for informing clinical guidance, are not well established. We explored the feasibility and acceptability of remote deployment and the fidelity of long-term data collection for both light levels and sleep within participants' homes. The original TWLITE study utilized a whole-home tunable lighting system, while the current project is an observational study of the light environment already existing in the home. This was a longitudinal, observational, prospective pilot study involving light sensors remotely deployed in the homes of healthy adults (<i>n</i> = 16, mean age: 71.7 years, standard deviation: 5.0 years) who were co-enrolled in the existing Collaborative Aging (in Place) Research Using Technology (CART) sub-study within the Oregon Center for Aging and Technology (ORCATECH). For 12 weeks, light levels were recorded via light sensors (ActiWatch Spectrum), nightly sleep metrics were recorded via mattress-based sensors, and daily activity was recorded via wrist-based actigraphy. Feasibility and acceptability outcomes indicated that participants found the equipment easy to use and unobtrusive. This proof-of-concept, feasibility/acceptability study provides evidence that light sensors can be remotely deployed to assess relationships between light exposure and sleep among older adults, paving the way for measurement of light levels in future studies examining lighting interventions to improve sleep.
Manufacturing techniques and excipients used during the design of biodegradable polymer-based microspheres containing therapeutic peptide/protein for parenteral controlled drug delivery. (2008)

In the last couple of decades, use of biodegradable polymer-based microspheres has been recognized as an interesting and promising approach for parenteral controlled delivery of therapeutic peptide/protein, including antigens. The main objectives of this review are (i) to update the current state of art of manufacturing of peptide/protein-loaded microspheres through both conventional and newer microencapsulation techniques, and (ii) to bring into focus the various possible instability problems, and the investigated mechanistic ways to obviate the instability problems of peptide/protein drug during microspheres preparation as well as its release from the microspheres. The solubilization, stabilization, and preservation enhancing excipients that are used in peptide/protein-loaded microspheres are briefly overviewed.
HW 03-1 RENAL SYMPATHETIC DENERVATION FOR RESISTANT HYPERTENSION UNDER OPTIMAL DRUG THERAPY (2016)

Catheter-based renal sympathetic denervation (RDN) has opened the new world in the treatment of resistant or refractory hypertension. However, SYMPLICITY HTN-3, 2:1 randomization, blinded and sham-controlled study did not show a significant reduction of systolic blood pressure (BP) in patients with resistant hypertension 6 months after RDN as compared with a sham control. After that, substudy investigating the predictors of BP responses in SYMPLICITY HTN-3 trial was reported; racial difference and optimal medical treatment were issued for the optimal denervation therapy. Recent data (GSR Korea data) showed RDN provided a significant reduction in 6- and 12-month office SBP among Asian patients, with a favorable safety profile. The 12-month systolic BP reduction was larger than that observed in Caucasian patients, suggesting there could be ethnic difference in the effects of RDN for resistant hypertension. The optimal medical therapy is still mainstay in the treatment of resistant hypertension. OSLO RDN trial suggest that adjusted drug treatment has superior BP lowering effects compared with RDN in patients with true resistant hypertension. In DENERHTN (Renal Denervation for Hypertension) trial demonstrated that RDN plus standardized stepped-care antihypertensive treatment decreased ambulatory BP more than the same medication alone at 6 months. For the successful RDN therapy causing BP decrease, the effective perfect denervation by complete catheter contact would be still most important. Related with this, we should pay attention to the upcoming new-generation multi-electrode system, one shot system. In conclusion, RDN therapy is not the end. However, we need a more concrete data and should await future studies.
Case report Transient uterine contraction mimicking adenomyosis on MRI (1998)

Transient myometrial contraction as a phy- siological phenomenon may simulate pathological conditions, such as a focal or diffuse adenomyosis. Clinicians should be aware of the potential presence of this phenomenon and imaging should be repeated after a suitable interval when the nature of a bulge or a region of low intensity in the myometrium is in doubt. In this paper, we report a transient myometrial contraction that mimics an adenomyosis, but disap- pears in repeated series.
ChemInform Abstract: Selective N‐Dealkylation of Tertiary Amines Derived from Phenylglycinol or Ephedrine Family. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microwave and ultrasound promoted synthesis of substituted new arylhydrazono pyridinones (2009)

A variety of arylhydrazonopyridinones 6a,b were prepared via heating cyanoacetamide derivative with ethyl acetoacetate in the absence of solvent under reflux conventionally or ultrasound irradiation or in a microwave oven then coupling with heteroaromatic diazonium salts. Several attempts were made to synthesize corresponding aminothienopyridinones 7a,b from 6a,b. Also, attempts to add electron poor olefins to 6a,b have failed and only arylhydrazonopyridinones recovered.
Studies on the constituents of asclepiadaceae plants. LXIV. The structure elucidation of cynafogenin. (1986)

Cynafogenin (1) contains two distinct ester groups, acetate and benzoate, located at C-11 and C-12, respectively. The positions of the ester linkages were determined by an application of the long-range selective proton decoupling (LSPD) technique. Further, the aromatic carbons of benzoate and the methyl carbons at C-18 and C-19 were assigned.
Real-time generation of natural language (1991)

A language-generation approach that benefits significantly from object-oriented techniques is presented. The system achieves simplicity and efficiency from a C++ implementation of linguistic knowledge. Sentences tailored for specific contexts and for specific readers are generated in real time, even when a large English grammar is processed. A sample problem illustrates the method. Limitations and implications of the approach are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table 2 from Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas (2023)

Supplementary Table 2 from Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. (2003)

Cells contain a large number of antioxidants to prevent or repair the damage caused by reactive oxygen species. One component of the antioxidant system, manganese superoxide dismutase (MnSOD), is localized in the mitochondria, and the levels of this protein have been previously shown to inversely correlate with pancreatic cancer cell growth. The aim of the present study was to determine whether MnSOD overexpression could suppress the in vitro and in vivo malignant phenotype of a human pancreatic cancer cell line. Tumor cell behavior was determined in the pancreatic cancer cell line MIA PaCa-2 by examining cell growth, plating efficiency, and anchorage-independent growth in soft agar. MnSOD was overexpressed in the pancreatic cancer cell line MIA PaCa-2 by infection with an adenovirus-MnSOD construct. Cells were also injected s.c. in nude mice and tumor volume was calculated. Single and multiple direct injections of the adenoviral MnSOD construct (10(9) plaque-forming units) were delivered to the tumor. Increases in MnSOD immunoreactivity and activity were seen after transduction with the adenovirus-MnSOD construct. Increasing MnSOD levels correlated with increased doubling time. Cell growth, plating efficiency, and growth in soft agar decreased with increasing amounts of the adenovirus MnSOD construct. Tumors grew slower and survival was increased in nude mice injected with the adenoviral MnSOD construct compared with the parental cell line, whereas multiple injections of the adenoviral MnSOD construct further inhibited tumor cell growth and extended survival. These results suggest that MnSOD may be a tumor suppressor gene in human pancreatic cancer. Delivery of the MnSOD gene may prove beneficial for suppression of pancreatic cancer growth.
The Impact of the COVID-19 Pandemic on the Radiology Research Enterprise: Radiology Scientific Expert Panel (2020)

The current coronavirus disease 2019 (COVID-19) crisis continues to grow and has resulted in marked changes to clinical operations. In parallel with clinical preparedness, universities have shut down most scientific research activities. Radiology researchers are currently grappling with these challenges that will continue to affect current and future imaging research. The purpose of this article is to describe the collective experiences of a diverse international group of academic radiology research programs in managing their response to the COVID-19 pandemic. The acute response at six distinct institutions will be described first, exploring common themes, challenges, priorities, and practices. This will be followed by reflections about the future of radiology research in the wake of the COVID-19 pandemic.
Neonatal Respiratory Insufficiency Caused by an (Homozygous) ABCA3-Stop Mutation: a Systematic Evaluation of Therapeutic Options (2014)

More experience in the treatment of newborns with ABCA3 gene mutations is needed. Randomized, prospective evaluation of the different therapeutic approaches in a specific registry may improve prognosis and treatment of affected individuals.