gebhart/patrepeval huggingface dataset:
Significantly different proliferative potential of oral mucosal epithelial cells between six animal species (2013)

There has been an upsurge in regenerative medicine in recent years. In particular, because oral mucosal epithelial cells can be obtained noninvasively, cultured epithelial cell sheets have been used in a number of ectopic transplantations. Additionally, the verification of the properties of experimental animals' cultured cells has accelerated the application of regenerative medicine. In the present study, the properties of oral mucosal epithelial cells were compared between six animal species. The human and pig epithelia were relatively thicker than the epithelia of the other species. The colony-forming efficiency of the rat was the highest, followed by those of the dog, human, rabbit, and pig, whereas the colonies of the mouse cells were all paraclone and uncountable in the colony-forming assay. We also found that the rabbit and pig cells proliferated poorly and were unable to form cell sheets without feeder layers. In contrast, even in the absence of feeder layers and cholera toxin, cultured dog and mouse cells formed contiguous sheets, when the cell seeding density was high. These results indicate that interspecies variation is considerable in oral mucosal epithelial cells and that specific experimental animal or human cells must be chosen according to the intended use.
Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine (2011)

Plasma levels of ADMA, SDMA, L-arginine, and L-arginine/ADMA ratio are reliable and feasible markers of an early ischemia-reperfusion injury. During CPB operation, the plasma concentration of ADMA increased significantly and remained elevated until the first postoperative day due to extensive ischemia-reperfusion injury caused by CPB.
Enforcing Eigenvector Smoothness for a Compact DFT-Based Polynomial Eigenvalue Decomposition (2018)

A variety of algorithms have been developed to compute an approximate polynomial matrix eigenvalue decomposition (PEVD). As an extension of the ordinary EVD to polynomial matrices, the PEVD will generate paraunitary matrices that diagonalise a parahermitian matrix. While iterative PEVD algorithms that compute a decomposition in the time domain have received a great deal of focus and algorithmic improvements in recent years, there has been less research in the field of frequency-based PEVD algorithms. Such algorithms have shown promise for the decomposition of problems of finite order, but the state-of-the-art requires a priori knowledge of the length of the polynomial matrices required in the decomposition. This paper presents a novel frequency-based PEVD algorithm which can compute an accurate decomposition without requiring this information. Also presented is a new metric for measuring a function's smoothness on the unit circle, which is utilised within the algorithm to maximise eigenvector smoothness for a compact decomposition, such that the polynomial eigenvectors have low order. We demonstrate through the use of simulations that the algorithm can achieve superior levels of decomposition accuracy to a state-of-the-art frequency-based method.
Multimodal estimation of a driver's spontaneous irritation (2009)

In this paper we present our latest achievements in the continuous estimation of a driver's spontaneous irritation. Experiments are conducted with data from 20 drivers, recorded under real driving conditions. While driving, participants also interact with a speech dialogue system to retrieve and play music. A fusion method is proposed to integrate information on the driving environment, driver behavior, driver's physiological state, and speech recognition results. Overall, we are able to correctly detect 80% (true positive rate) of the irritation, and, when drivers are not irritated, we only make mistakes 9% of the time (false positive rate). Results also support the relevance of gas- and brake-pedal operation as well as speech recognition results in irritation estimation.
Wideband optical elastography ofin vivohuman skin using geometrically focused surface waves (2014)

Viscoelastic models are fit to shear moduli derived from geometrically focused surface waves (GFS) on human skin using viscoelastic wave theory. Unlike in previous studies on the analytical solution and experimental measurement of radially outward traveling surface waves, measurable radially inward traveling GFS waves can be generated over a wider range of frequencies as attenuation is countered by the converging nature of the wavefront. This enables a more accurate and broader assessment of both the shear storage and loss moduli of the material, which are expected to vary with frequency. In the present study, GFS waves are applied to human skin on the posterior side of the forearm using a scanning LASER Doppler vibrometer. Surface wave measurements can then be used to estimate the complex frequency dependent viscoelastic properties of biological tissue, which are affected by numerous pathologies. Using a phantom gel this technique was validated through comparison with other studies. It was found that spring-pot and fractional Voigt models yield a potentially stable model parameter for skin, but more study is needed to confirm. [Work supported by NIH: Grant # EB012142.]
Metoprine-induced thirst and diuresis in Wistar rats (1999)

In the present study, the renal responses to metoprine, a histamine-N-methyltransferase inhibitor, were studied in conscious rats. Metoprine (10-20 mg kg(-1)) or vehicle were administered i.p. to male Wistar rats and the effects were followed for the subsequent 24 h. It was found that as early as 3 h after the drug administration metoprine 20 mg kg(-1) had increased water consumption and urine flow approximately 6-8-fold. The treatment decreased urine osmolality and increased free water clearance, but caused no change in plasma renin activity or plasma vasopressin concentration. In addition, a metoprine-induced elevation in the systolic blood pressure was observed during the first few hours of the experiment. During the nocturnal period of the study, glomerular filtration rate and the excretion of electrolytes did not increase in metoprine-treated rats as they did in control rats. A decrease in the release of atrial natriuretic peptide was also found. The present results show that inhibition of histamine catabolism by metoprine causes massive changes in renal functions. It seems to promote water excretion by the kidneys but, on the other hand, to reduce the excretion of electrolytes. Although the exact mechanisms, especially the role of increased blood pressure and nocturnal suppression of atrial natriuretic peptide, require further clarification, the present data suggest that renin-angiotensin system and vasopressin were not involved in these renal responses to metoprine.
Processing and enhanced piezoelectric properties of highly oriented compositionally modified Pb(Zr,Ti)O3ceramics fabricated by magnetic alignment (2015)

Highly oriented compositionally modified Pb(Zr,Ti)O3 (PZT) ceramics were successfully obtained by slip casting in a high magnetic field. PZT is a well-known superior ceramic with the highest piezoelectric properties, and these properties have been expected to be further improved through crystalline orientation. However, highly oriented PZT ceramics fabricated by slip casting in a high magnetic field have never been reported. We obtained oriented ceramics using compositionally modified PZT with Pb(Ni,Nb)O3, and their Lotgering factor was 0.77. The electromechanical coupling coefficient (k31) increased by 30%, and an extremely high value of 0.44 was achieved for the oriented ceramics.
Comprehensive study of the alkylation of thiophenic (2012)

International @ RAFFINAGE+GTU:DLA:MTF:CGE
Robust estimation of print mottle (2007)

Mottle is a common defect in printing. Mottle evaluation is crucial in image quality assessment and system diagnosis. In this paper, we present a new automatic mottle estimation method which improves the existing technologies in two aspects. First, a modified mottle noise frequency range is proposed, which further separates the banding and streak spectra from mottle spectrum. Second, a robust estimation algorithm is introduced. It is less sensitive to the outliers that may appear in the measurement. These outliers include other defects within the mottle frequency range, such as spots, or defects outside of mottle frequency range, but are strong enough that can not be completely eliminated by normal spatial filtering.
Parallelized Kalman-Filter-Based Reconstruction of Particle Tracks on Many-Core Processors and GPUs (2017)

For over a decade now, physical and energy constraints have limited clock speed improvements in commodity microprocessors. Instead, chipmakers have been pushed into producing lower-power, multi-core processors such as Graphical Processing Units (GPU), ARM CPUs, and Intel MICs. Broad-based efforts from manufacturers and developers have been devoted to making these processors user-friendly enough to perform general computations. However, extracting performance from a larger number of cores, as well as specialized vector or SIMD units, requires special care in algorithm design and code optimization. One of the most computationally challenging problems in high-energy particle experiments is finding and fitting the charged-particle tracks during event reconstruction. This is expected to become by far the dominant problem at the High-Luminosity Large Hadron Collider (HL-LHC), for example. Today the most common track finding methods are those based on the Kalman filter. Experience with Kalman techniques on real tracking detector systems has shown that they are robust and provide high physics performance. This is why they are currently in use at the LHC, both in the trigger and offine. Previously we reported on the significant parallel speedups that resulted from our investigations to adapt Kalman filters to track fitting and track building on Intel Xeon and Xeon Phi. Here, we discuss our progresses toward the understanding of these processors and the new developments to port the Kalman filter to NVIDIA GPUs.
Persisting Bone Marrow Aplasia Following Interferon-Alpha Combined with Ara-C for Chronic Myelogenous Leukemia (1999)

A 37-year-old man with a newly diagnosed chronic myelogenous leukemia received induction therapy with hydroxyurea and interferon-alpha, and maintenance therapy with low-dose ara-C and interferon-alpha. Subsequent to a rapid hematological remission, a continuously aggravating pancytopenia with bone marrow aplasia developed which persisted after withdrawal of maintenance therapy. Bone marrow examination exhibited aplastic areas and residual hematopoiesis with impaired maturation; cytogenetically, there was a 100% persistence of Philadelphia chromosome-positive metaphases. By allogeneic bone marrow transplantation, a complete reconstitution of hematopoiesis was achieved.
Deriving activity from RFID detection records in an assisted living context (2008)

There has been a significant growth in the deployment of Radio Frequency Identification (RFID) in the supply chain in the recent years. Since RFID requires less cost and infrastructure than the sensor networks such as Ultrasonic or Wi-Fi, it has been applied in many business and research domains. The major applications of RFID technology include location position, object tracking and activity monitoring. Particularly in the individual activity monitoring circumstance, it is expected that by detecting the object with which the person interacted, the related personal movement is able to be recognized. However, the inherent unreliability of RFID data results in the uncertainty of the RFID detection of activity. This research estimates the accuracy of using RFID detection records to monitor personal activity in an assisted living context. The methodology for this research is a quantitative approach by using design science. Two real experiments are conducted for performing activity monitoring in a laboratory environment. Both experiment results show that false positive reads have a serious influence on the accuracy of detecting individual motion. In order to remove the noisy data from the original RFID data stream, the multi-level data pre-processing method is used and analysed in the research. The cleaned dataset shows the perfect accuracy of personal activity inference. Although this proposed method is efficient for filtering the noisy data and predicting the correct individual movement in this research, it only focuses on recognizing the regular personal activity in a clean indoor environment. Due to the complexity of human indoor behaviour, future exploration needs to be carried out in other different environmental backgrounds.
Pulse assessment is important with blood pressure measurement in individuals with continuous flow left ventricular assist devices (2020)

While Doppler and cuff blood pressure techniques are prevalent methods of assessing blood pressure in patients with continuous flow left ventricular assist devices, the impact of pulsatility on measurement is not well established. Retrospective chart analysis of clinical variables including pulse perception, blood pressure (Doppler and standard cuff), and aortic valve opening on echo at clinic visit were abstracted. Stable outpatients on continuous flow left ventricular assist devices support with concomitant portable echo assessment were included. Mean average difference was calculated and Pearson's correlation performed for all those patients who had both Doppler and cuff pressure obtained. In all, 74 Heartmate-II patients with a median time from implant of 380 days were analyzed. A pulse was perceived in 82% of patients with persistent aortic valve opening on portable echo and also in 30% of those who had a persistently closed aortic valve. The mean average difference between the Doppler and systolic cuff pressure was ~13 mmHg (<i>r</i> = 0.5, <i>p</i> = 0.004) when a pulse was present and ~11 mmHg when aortic valve was open (<i>r</i> = 0.68, <i>p</i> < 0.0001). Pulse presence seems to reflect aortic valve opening a majority of the time but not always. In the presence of a prominent pulse or persistent aortic valve opening, the Doppler pressure seems to be more reflective of a systolic pressure than mean perfusion pressure. Hence, assessment of pulsatility needs to be incorporated into blood pressure measurement methods for patients with continuous flow left ventricular assist devices.
Spatial light-modulated stimulated Raman scattering (SLM-SRS) microscopy for rapid multiplexed vibrational imaging (2019)

High speed imaging is pre-requisite for monitoring of dynamic processes in biological events. Here we report the development of a unique spatial light-modulated stimulated Raman scattering (SLM-SRS) microscopy that tailors the broadband excitation beam with sparse-sampling masks designed for rapid multiplexed vibrational imaging to monitor real-time cancer treatment effects and <i>in vivo</i> transport of drug solvent. <b>Methods:</b> We design an optimal mask pattern that enables selection of predominant windows in SRS spectrum for collective excitation at the highest possible peak power, thus providing an improved signal-to-noise ratio (SNR) without compromise of chemical specificity. The mask pattern generated is applied to the broad excitation beam using a flexible spatial light modulator. The SLM module further offers complementary function whereby rapid scanning of SRS spectrum can be facilitated prior to the mask generation, thereby making the SLM-SRS system a stand-alone imaging platform. <b>Results:</b> We demonstrate that SLM-SRS microscopy permits rapid multiplexed SRS imaging of polystyrene and polymethyl methacrylate beads in Brownian motion in dimethyl sulfoxide (DMSO) at 70 ms intervals without motion artiacts. We further apply SLM-SRS to monitor the therapeautic effect of mild alkaline solution on cancer cells, which shows immediate apoptotic response. Finally, we visualize <i>in vivo</i> penetration of DMSO into the plant tissue and evaluate acute toxicity of DMSO on cellulose and proteins within the tissue. <b>Conclusion:</b> We develop novel SLM-SRS microscopy and affirm its broad applicability for rapid monitoring of dynamic biological processes at the subcellular and molecular level.
Impact of UV radiation on the red seaweed Gelidium lingulatum and its associated bacteria (2020)

Sergey Dobretsovab* , Karina Vélizc, María Soledad Romeroc, Fadia Talacd & Martin Thielcefa Department of Marine Science and Fisheries, Sultan Qaboos University, Muscat, Omanb Center of Excellence in Marine Biotechnology, Sultan Qaboos University, Muscat, Omanc Departamento de Biología Marina, Universidad Católica del Norte, Coquimbo, Chiled Centro de Investigación y Desarrollo Tecnológico en Algas (CIDTA), Facultad de Ciencias del Mar, Universidad Católica del Norte, Coquimbo, Chilee Millennium Nucleus Ecology and Sustainable Management of Oceanic Island (ESMOI), Coquimbo, Chilef Centro de Estudios Avanzados en Zonas Áridas, Coquimbo, Chile
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells (1992)

Synthetic lipopeptide analogues of the N-terminus of bacterial lipoprotein are effective activators of macrophages, neutrophils and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]- (R)-cysteinyl-(S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3Cys-Ser-(Lys)4] on tyrosine phosphorylation in dibutyryl-cyclic-AMP-differentiated HL-60 cells, using anti-phosphotyrosine antibodies. Pam3Cys-Ser-(Lys)4 concentration-dependently stimulated tyrosine phosphorylation of 100/110 kDa and 60 kDa proteins and, to a lesser extent, of 55 kDa and 70/75 kDa proteins. Half-maximal and maximal effects were observed at concentrations of 1-6 and 5-50 micrograms/ml respectively. The lipopeptide-induced increase in phosphorylation was rapid and transient, with a peak response after 30-60 s. The lipopeptide (2S)-2-palmitoylamino-6-palmitoyloxymethyl-7-palmitoyloxy heptanoyl-Ser-(Lys)4 [Pam3Ahh-Ser-(Lys)4] was as potent as Pam3Cys-Ser(Lys)4, whereas (2S,6S)-2-palmitoylamino-6,7-bis(palmitoyloxy)heptanoyl++ +-Ser-(Lys)4 [Pam3Adh-Ser-(Lys)4] and Pam3Cys-Ser-Gly did not induce tyrosine phosphorylation. Lipopeptide-induced tyrosine phosphorylation was not affected by treatment of cells with pertussis toxin. Neither phorbol 12-myristate 13-acetate nor A23187 induced tyrosine phosphorylation in dibutyryl-cyclic-AMP-differentiated HL-60 cells. In HL-60 promyelocytes, Pam3Cys-Ser-(Lys)4 had no effect on tyrosine phosphorylation, whereas the lipopeptide also induced tyrosine phosphorylation in 1,25-dihydroxyvitamin-D3-differentiated HL-60 cells and in human neutrophils. These results show that lipopeptides are effective stimulators of tyrosine phosphorylation in mature human myeloid cells.
NIOM for Spinal Deformity Surgery (2012)

The combined use of somatosensory evoked potentials, transcranial electric motor evoked potentials, descending neurogenic evoked potentials, and electromyography monitoring allowed accurate detection of permanent neurologic status in 99.6% of 3436 patients and reduced the total number of permanent neurologic injuries to 6.
Agonist-Biased Signaling at the sst2A Receptor: The Multi-Somatostatin Analogs KE108 and SOM230 Activate and Antagonize Distinct Signaling Pathways (2009)

Somatostatin analogs that activate the somatostatin subtype 2A (sst2A) receptor are used to treat neuroendocrine cancers because they inhibit tumor secretion and growth. Recently, new analogs capable of activating multiple somatostatin receptor subtypes have been developed to increase tumor responsiveness. We tested two such multi-somatostatin analogs for functional selectivity at the sst2A receptor: SOM230, which activates sst1, sst2, sst3, and sst5 receptors, and KE108, which activates all sst receptor subtypes. Both compounds are reported to act as full agonists at their target sst receptors. In sst2A-expressing HEK293 cells, somatostatin inhibited cAMP production, stimulated intracellular calcium accumulation, and increased ERK phosphorylation. SOM230 and KE108 were also potent inhibitors of cAMP accumulation, as expected. However, they antagonized somatostatin stimulation of intracellular calcium and behaved as partial agonists/antagonists for ERK phosphorylation. In pancreatic AR42J cells, which express sst2A receptors endogenously, SOM230 and KE108 were both full agonists for cAMP inhibition. However, although somatostatin increased intracellular calcium and ERK phosphorylation, SOM230 and KE108 again antagonized these effects. Distinct mechanisms were involved in sst2A receptor signaling in AR42J cells; pertussis toxin pretreatment blocked somatostatin inhibition of cAMP accumulation but not the stimulation of intracellular calcium and ERK phosphorylation. Our results demonstrate that SOM230 and KE108 behave as agonists for inhibition of adenylyl cyclase but antagonize somatostatin's actions on intracellular calcium and ERK phosphorylation. Thus, SOM230 and KE108 are not somatostatin mimics, and their functional selectivity at sst2A receptors must be considered in clinical applications where it may have important consequences for therapy.
Statistical thermodynamics of liquid mixtures: A new expression for the excess Gibbs energy of partly or completely miscible systems (1975)

Abstract To obtain a semi‐theoretical equation for the excess Gibbs energy of a liquid mixture, Guggenheim's quasi‐chemical analysis is generalized through introduction of the local area fraction as the primary concentration variable. The resulting universal quasi‐chemical (UNIQUAC) equation uses only two adjustable parameters per binary. Extension to multicomponent systems requires no ternary (or higher) parameters. The UNIQUAC equation gives good representation of both vapor‐liquid and liquid‐liquid equilibria for binary and multicomponent mixtures containing a variety of nonelectrolyte components such as hydrocarbons, ketones, esters, amines, alcohols, nitriles, etc., and water. When well‐defined simplifying assumptions are introduced into the generalized quasi‐chemical treatment, the UNIQUAC equation reduces to any one of several well‐known equations for the excess Gibbs energy, including the Wilson, Margules, van Laar, and NRTL equations. The effects of molecular size and shape are introduced through structural parameters obtained from pure‐component data and through use of Staverman's combinatorial entropy as a boundary condition for athermal mixtures. The UNIQUAC equation, therefore, is applicable also to polymer solutions.
Molybdenum container development for Na/S cells (2003)

The authors describe the progress which has been made to date in the utilization of molybdenum as a cathode container material for aerospace sodium/sulfur cells. Two basic designs were utilized during this effort. The first of these was a tubular, central sodium cell designed for application in spacecraft batteries in geosynchronous earth orbits. The second cell was a flat plate cell designed as a proof-of-concept cell for use in a bipolar configuration in high, pulsed power applications. These two types of cells are described. The welding development process is outlined. The initial thermo-compression bonding trials of molybdenum to alpha-alumina are discussed. Typical performance characteristics for the two cell types are summarized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>