gebhart/patrepeval huggingface dataset:
A highly polymorphic locus is detected by probe CARLP II6.3 [D5S88] (1988)

Journal Article A highly polymorphic locus is detected by probe CARLP II6.3 [D5S88] Get access Peter Raeymaekers, Peter Raeymaekers Department of Biochemistry, Universitaire Instelling AntwerpenUIA, Universiteitsplein 1, B26l0 Wilrijk, Antwerp, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Christine Van Broeckhoven, Christine Van Broeckhoven Department of Biochemistry, Universitaire Instelling AntwerpenUIA, Universiteitsplein 1, B26l0 Wilrijk, Antwerp, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Antoon Vandenberghe Antoon Vandenberghe Department of Biochemistry, Universitaire Instelling AntwerpenUIA, Universiteitsplein 1, B26l0 Wilrijk, Antwerp, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 16, 25 August 1988, Page 8196, https://doi.org/10.1093/nar/16.16.8196 Published: 25 August 1988
Design, Characterization, and Application of Fast, Broadband, High-Dynamic Range, Three-Axis Field Strength Probes (2013)

Conventional field strength sensors use different detection methods, each having advantages and disadvantages. Modern signals in, for instance, wireless communication systems and radars use very complex modulation. Other signals, such as the ones often measured in reverberation chambers with mode stirring, are fast-varying with high dynamic range. Conventional probes struggle to give reliable measurement data in these situations, while the more expensive solutions based on optical-electric conversion and heterodyne receiver, are so costly that often only one component of the field is measured. The impact of conventional field strength probes when measuring (complex) modulated signals is discussed. Furthermore, this paper describes the design, fabrication, and characterization of fast, broadband, three-axis, and high-dynamic range probes. They have been designed for mapping the fast-changing electric field strength in complex electromagnetic environments such as reverberation chambers under mode-stirring operation.
Role of nitric oxide and guanosine 3′,5′‐cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea‐pig pulmonary arteries (1992)

1. Nonadrenergic, noncholinergic (NANC) nerves mediate vasodilatation in guinea-pig pulmonary artery (PA) by both endothelium-dependent and endothelium-independent mechanisms. The transmitter(s) involved in the endothelium-independent pathway have not yet been identified. We have therefore investigated the possibility that nitric oxide (NO) and guanosine 3',5'-cyclic monophosphate (cyclic GMP) may mediate this neural vasodilator response in guinea-pig branch PA rings denuded of endothelium. 2. Electric field stimulation (EFS, 50 V, 0.2 ms) induced a frequency-dependent (1-24 Hz), tetrodotoxin-sensitive relaxation of the U44069-precontracted PA rings in the presence of adrenergic and cholinergic blockade. 3. The NO synthase inhibitors NG-monomethyl L-arginine (L-NMMA, 100 microM) and NG-nitro L-arginine methyl ester (L-NAME, 30 microM), and the guanylyl cyclase inhibitor methylene blue (5 microM) inhibited the EFS (16 Hz)-induced relaxation by 53 +/- 5, 74 +/- 9 and 82 +/- 9% respectively (n = 5-7, P < 0.01, compared with control rings). 4. Excess concentrations of L-, but not D-arginine (300 microM) completely reversed the inhibitory effect of L-NMMA. 5. The EFS-elicited relaxation (4 Hz) was potentiated by 1 microM zaprinast, a type V phosphodiesterase inhibitor which inhibits guanosine 3':5'-cyclic monophosphate (cyclic GMP) degradation, but was unaffected by 0.1 microM zardaverine, a type III/IV phosphodiesterase inhibitor which inhibits cyclic AMP degradation. 6. EFS (50 V, 0.2 ms, 16 Hz) induced a 3 fold increase in tissue cyclic GMP content, an action which was inhibited by L-NMMA (100 microM). 7. Pyrogallol (100microM), a superoxide anion generator, also inhibited the EFS-induced relaxation by 53 +/- 9%, and this effect was prevented by superoxide dismutase.8. Chemical sympathetic denervation with 6-hydroxydopamine had no effect on the relaxant response to EFS in the endothelium-denuded PA rings.9. In endothelium-denuded branch PA rings at resting tone, L-NMMA (100 microM) significantly augmented the adrenergic contractile response, an effect which was completely reversed by L-arginine,but not by D-arginine. In the same groups of vessel rings, L-NMMA had no significant effect on the matched contractile response to exogenous noradrenaline.10. These results suggest that NO may be released from intramural nerve endings other than adrenergic nerves (probably NANC nerves), and this leads to vasodilatation via activation of guanylyl cyclase.
Two different thymidylate kinase gene homologues, including one that has catalytic activity, are encoded in the onion yellows phytoplasma genome (2003)

Thymidylate kinase (TMK) catalyses the phosphorylation of dTMP to form dTDP in both the de novo and salvage pathways of dTTP synthesis in both prokaryotes and eukaryotes. Two homologues of bacterial thymidylate kinase genes were identified in a genomic library of the onion yellows (OY) phytoplasma, a plant pathogen that inhabits both plant phloem and the organs of insects. Southern blotting analysis suggested that the OY genome contained one copy of the tmk-b gene and multiple copies of the tmk-a gene. Sequencing of PCR products generated by amplification of tmk-a enabled identification of three other copies of tmk-a, although the ORF in each of these was interrupted by point mutations. The proteins, TMK-a and TMK-b, encoded by the two intact genes contained conserved motifs for catalytic activity. Both proteins were overexpressed as fusion proteins with a polyhistidine tag in Escherichia coli and purified, and TMK-b was shown to have thymidylate kinase activity. This is believed to be the first report of the catalytic activity of a phytoplasmal protein, and the OY phytoplasma is the first bacterial species to be found to have two intact homologues of tmk in its genome.
Инфракрасная спектроскопия и комбинационное рассеяние света в поликристаллах глицина и тирозина (2016)

The study tested the low-frequency Raman spectra of crystal lattices of glycine and tyrosine amino acids and revealed intense sharp lines corresponding to the libration modes, related to pseudoscalar symmetry type. We found the essential difference between spectra of pure and racemic chiral phases of amino acids. The obtained results are useful for monitoring the chiral purity states of bioactive substances containing amino acids
Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: A matched control study (2002)

Infections contribute significantly to morbidity and mortality after myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). Whether recipients of nonmyeloablative HSCT have different posttransplantation infection risk was unknown. We therefore analyzed the incidence and risk of bacteremia during the first 100 days and of fungal infection during the first 365 days posttransplantation for 56 consecutive patients with hematological malignant disease who received nonmyeloablative HSCT (case patients). We compared the results with those among 112 control patients who received conventional myeloablative HSCT during the same years (January 1997-April 2000). Control patients were matched (2:1) for cytomegalovirus (CMV) risk group, HSC source, donor type, age, and underlying disease. Most donors (93%) were HLA-matched and related. Case patients had shorter periods of neutropenia (absolute neutrophil count, <100/mm3) than did control patients (median, 0 days; range, 0-11 versus 9 days; range, 4-25; P < .0001). This finding was associated with fewer episodes of bacteremia during the first 30 days (9% versus 27%; P = .01) and a trend to fewer episodes of bacteremia during the first 100 days posttransplantation (27% versus 41%, P = .07). Overall survival was significantly improved in case patients compared with control patients (day 100, 93% versus 81%; P = .04). During the first year posttransplantation, invasive aspergillosis occurred at a similar rate (case patients, 15%; control patients, 9%; P value not significant). Multivariate risk factor analyses identified neutropenia and CMV disease as the major factors associated with bacteremia and aspergillosis, respectively. We conclude that shorter periods of severe neutropenia in nonmyeloablative HSCT are associated with decreased risk of early bacteremia, although risk of fungal infection late after HSCT persists. This risk is an important consideration for the future development of preventive strategies.
Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 2. A Computational Approach (1999)

The molecular recognition of C2- or C8-substituted ATP derivatives by the P2Y(1)-receptor (P2Y(1)-R) is analyzed using ab initio quantum mechanical calculations. Parameters that may determine ligand specificity toward P2Y(1)-R were examined on reduced models and correlated with the biochemical data for the parent compounds. These include tautomerism and protonation energy in the gas and aqueous phases, as well as molecular electrostatic potential (MEP) and dipole moment vector. The calculated electronic parameters cannot explain the inactivity of the C8-substituted ATP derivatives, nor the difference in activity among the C2-substituted ATP analogues. These results indicate that neither tautomerism nor changes in the electronic distribution of the adenine ring play a major role in determining binding specificity of adenine nucleotides to the receptor. It is suggested that the higher potency of the C2-substituted ATP derivatives, compared to ATP, might be due to interaction between the C2 side chain heteroatom and the receptor. Furthermore, the interaction of the C2 alkyl side chain with a hydrophobic pocket at the receptor binding site is suggested. In addition, NMR data in the companion paper indicate that the inactivity of the C8-substituted ATP analogues may be due to steric and conformational, rather than electronic, effects.
A General Mixture Model for Nonlinear Heterogeneous Tumor Growth (2017)

In this paper we develop a general mixture model that incorporates a non-constant water fraction. A novel energy for the system is devised that allows for different water levels to be considered in the host and viable cell regions. For the first time the energy provides a way to flux the water out of the necrotic core and produce stable tumor spheroids with liquid centers. The model is also capable of producing invasive tumors with a detailed morphology. Parameter studies are performed to characterize the model. The parameters that can influence the size of the stable tumor and the growth rate are identified and the parameter regimes that can destabilize the tumor are explored. We demonstrate that this model is able to capture a wide range of tumor behavior. In particular, water fraction parameters for the host and viable cell regions allows us to consider the effects of different water fraction levels in the host and viable cell regions. Finally, the non-constant water fraction model is extended to describe hierarchical structures that incorporate cancer stem cells. This model is capable of producing a detailed invasive morphology that has hierarchical and heterogeneous cell distributions and develops necrotic cores. The model is also capable of forming stable tumors with heterogeneous cell distributions. A parameter study on the positive and negative feedback rates for the stem cell differentiation rate shows how the morphology of the tumor is dependent on the sensitivity to these parameters and possible avenues for therapy are seen.
MixSize: Training Convnets With Mixed Image Sizes for Improved Accuracy, Speed and Scale Resiliency (2021)

Convolutional neural networks (CNNs) are commonly trained using a fixed spatial image size predetermined for a given model. Although trained on images of a specific size, it is well established that CNNs can be used to evaluate a wide range of image sizes at test time, by adjusting the size of intermediate feature maps. In this work, we describe and evaluate a novel mixed-size training regime that mixes several image sizes at training time. We demonstrate that models trained using our method are more resilient to image size changes and generalize well even on small images. This allows faster inference by using smaller images at test time. For instance, we receive a 76.43% top-1 accuracy using ResNet50 with an image size of 160, which matches the accuracy of the baseline model with 2× fewer computations. Furthermore, for a given image size used at test time, we show this method can be exploited either to accelerate training or the final test accuracy. For example, we are able to reach a 79.27% accuracy with a model evaluated at a 288 spatial size for a relative improvement of 14% over the baseline. Our PyTorch implementation and pre-trained models are publicly available\footnote{\url{https://github.com/paper-submissions/mix-match}
Synthesis of 2‐alkoxy‐6‐aryl‐5‐cyano‐4(3H)‐pyrimidinones (1982)

Abstract The reaction of methyl 3‐aryl‐2‐cyano‐3‐methoxypropenoates 1 with cyanamide and sodium methoxide in methanol afforded after acid hydrolysis the methyl 3‐[(aminocarbonyl)amino]‐3‐aryl‐2‐cyanopropenoates 4 . By performing the reaction in higher boiling alcohols the 2‐alkoxy‐6‐aryl‐5‐cyano‐4(3 H )‐pyrimidinones 2 were obtained in good yields.
Dynamic Characteristics Analysis and Dynamic Model Modification on a Small Scale Vertical Axis Wind Turbine (2017)

The dynamic characteristics including natural frequencies and excitation frequencies were evaluated for a small 10 kW vertical axis wind turbine for investigating the root cause of excessive vibration of a structure under 30RPM of rotor speed. Acceleration responses were measured at 12 distributed locations for ambient vibration tests during non-operational and operational conditions. The natural frequencies for the lowest 2 bending modes were estimated and the excitation frequencies, i.e. 1P, 2P, 4P, were also estimated according to the rotational speed using the responses under operational conditions (i.e. power generation condition). It was verified that the excessive vibration was due to the resonance between the 4P excitation and the 1st vibration modes. To resolve the resonance issue, dynamic model modification was carried out and concrete filling inside the steel tower up to 7 m height was the most efficient way to increase the 1st natural frequency about 20% by numerical simulation. After the concrete filling, the acceleration responses were measured again and it was observed that the 1st natural frequency was increased as amount of 21% by concrete filling.
Interaction between iron(0) and formaldehyde, thioformaldehyde, and acetone: ab initio calculations on the model compounds Fe(CO)2(PH3)2(.eta.2-CH2O), Fe(CO)2(PH3)2(.eta.2-CH2S), Fe(PH3)4(.eta.2-CH2O), and Fe(PH3)4(.eta.2-CMe2O) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction between iron(0) and formaldehyde, thioformaldehyde, and acetone: ab initio calculations on the model compounds Fe(CO)2(PH3)2(.eta.2-CH2O), Fe(CO)2(PH3)2(.eta.2-CH2S), Fe(PH3)4(.eta.2-CH2O), and Fe(PH3)4(.eta.2-CMe2O)M. Rosi, A. Sgamellotti, F. Tarantelli, and C. FlorianiCite this: Inorg. Chem. 1988, 27, 1, 69–73Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ic00274a016https://doi.org/10.1021/ic00274a016research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A framework for real time communication in sensor networks (2010)

The introduction of real time communication has created additional challenges in the wireless networks area with different communication constraints. Sensor nodes spend most of their lifetime functioning as a small router to deliver packets from one node to another until the packet reaches the sink. Since sensor networks represent a new generation of time-critical applications, it is often necessary for communication to meet real time constraints as well as other constrains. Nevertheless, research dealing with providing QoS guarantees for real time traffic in sensor networks is still in its infancy. This paper presents a novel packet delivery mechanism, namely Multiple Level Stateless Protocol (MLSP), as a real time protocol for sensor networks to guarantee the quality of traffic in wireless Sensor Networks. MLSP improves the packet loss rate and handles holes in sensor networks. This paper also introduces the k-limited polling model. This model is used in a sensor network by the implementation of two queues served according to a 2-limited polling model in a sensor node. Here, two different classes of traffic are considered and the exact packet delay for each corresponding class is calculated. The analytical results are validated through an extensive simulation study.
A modeling cross-spectral analysis technique based on the Prony Spectral Line Estimator (PSLE) (1994)

The Cross-Prony Spectral Line Estimator (XPSLE) is proposed for spectral comparison of short data records. Basic theory is discussed. The XPSLE method is tested on pairs of synthetic data records and is shown to be sensitive to disparity of spectral content. Application to analysis of arteriolar vasomotion is discussed.
How I Learned to Stop Worrying and Love Re-optimization (2019)

Cost-based query optimizers remain one of the most important components of database management systems for analytic workloads. Though modern optimizers select plans close to optimal performance in the common case, a small number of queries are an order of magnitude slower than they could be. In this paper we investigate why this is still the case, despite decades of improvements to cost models, plan enumeration, and cardinality estimation. We demonstrate why we believe that a re-optimization mechanism is likely the most cost-effective way to improve end-to-end query performance. We find that even a simple re-optimization scheme can improve the latency of many poorly performing queries. We demonstrate that re-optimization improves the end-to-end latency of the top 20 longest running queries in the Join Order Benchmark by 27%, realizing most of the benefit of perfect cardinality estimation.
Fermentative Production of L-Arginine (1972)

Most of the bacteria, which were examined for the sensitivity to l-arginine analogs (l-canavanine, l-homoarginine, d-arginine and arginine hydroxamate), were insensitive to the analogs at a concentration of 8 mg/ml. Corynebacterium glutamicum DSS-8 isolated as d-serine-sensitive mutant from an isoleucine auxotroph KY 10150, was found to be sensitive to d-arginine and arginine hydroxamate. Furthermore, DSS-8 produced l-arginine in a cultural medium. l-Arginine analog-resistant mutants were derived from DSS-8 by N-methyl-N′-nitro-N-nitrosoguanidine (NTG) treatment. Most of them were found to produce a large amount of l-arginine. An isoleucine revertant from one of these mutants produced 19.6 mg/ml of l-arginine in the medium containing 15% (as sugar) of molasses. The mechanism of the sensitivity to l-arginine analogs and that of the production of l-arginine in the d-serine-sensitive mutant, DSS-8, were investigated. DSS-8 seems to be a mutant having increased permeability to d- and l-arginine.
Mechanism Design for Correlated Valuations: Efficient Methods for Revenue Maximization (2021)

Traditionally, much of the focus of the mechanism/auction design community has been on revenue optimal mechanisms for settings where bidders’ private valuations over outcomes can be reasonably thought of as independent of each other. This has been the case even though there is good reason to believe that valuations are often correlated and there are theoretical results suggesting that mechanisms designed with this correlation in mind can generate much higher revenue. In “Mechanism Design for Correlated Valuations: Efficient Methods for Revenue Maximization,” we look at the setting where there is correlation, but the exact distribution is unknown and must be estimated from samples. We show that in this setting, the previous extremely strong theoretical results around the usefulness of correlation are now very sensitive to the degree of correlation in the underlying distribution and the number of samples that the mechanism designer has access to. However, we also show that if correlation is sufficient, we can construct mechanisms, using a computationally efficient procedure, that significantly outperform traditional mechanism design paradigms.
An Influence of Fructan Containing Concentrate from Jerusalem Artichoke Tubers on the Development of Probiotic Dairy Starters on Milk and Oat-based Substrates (2007)

Abstract Supplementation of milk and oat hydrolysate containing medium with Jerusalem artichoke concentrate (JAC) and subsequent fermentation with probiotic dairy starters resulted in substantial stimulation of probiotics Bifidobacterium lactis and Lactobacillus acidophilus as well as yogurt starter culture Lactobacillus bulgaricus development and acidification rate. The strain-specific responses of the general yogurt cultures, as well as probiotics to the addition of JAC, should be considered to achieve optimal composition of probiotic strains and conformable fermentation conditions. JAC is suggested to be perspective prebiotic additive for fermented synbiotic milks or oat-hydrolysate-based products. Key Words: probioticfructansJerusalem artichokefermented milksoatsstarter cultures ACKNOWLEDGMENTS This study was supported by the European Social Foundation, Project ESSS 2004/3, Contracts' Nr. 2004/0001/VPD1/ESF/PIAA/04/NP/3.2.3.1/0001/0063
ChemInform Abstract: Allyl Complexes of Pentaammineosmium. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.