gebhart/patrepeval huggingface dataset:
Targeting RET Kinase in Neuroendocrine Prostate Cancer (2019)

Abstract Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also express neuroendocrine markers, termed neuroendocrine prostate cancer (NEPC). Recent evidence suggests kinase signaling may be an important driver of NEPC. To identify targetable kinases in NEPC, we performed global phosphoproteomics comparing AR-negative to AR-positive prostate cancer cell lines and identified multiple altered signaling pathways, including enrichment of RET kinase activity in the AR-negative cell lines. Clinical NEPC and NEPC patient derived xenografts displayed upregulated RET transcript and RET pathway activity. Pharmacologically inhibiting RET kinase in NEPC models dramatically reduced tumor growth and cell viability in mouse and human NEPC models. Our results suggest that targeting RET in NEPC tumors with high RET expression and may be a novel treatment option. Statement of Significance There are limited treatment options for patients with metastatic aggressive variant prostate cancer and none are curative. Here we identified aberrantly activated RET kinase signaling in multiple models of NEPC. Inhibiting RET restricted tumor growth, providing a novel approach for treating NEPC.
Design and Performance Evaluation of a Compact Beam-Tilted Circularly Polarized Slotted Waveguide Antenna (2022)

This paper presents design configuration and performance analysis of a compact and thin beam-tilted circularly polarised (CP) radial line slot array (RLSA) waveguide antenna. In conventional CP RLSA beam-tilting method, the aperture efficiency degrades significantly due to sparsely distributed slots throughout the aperture. In this paper, we have presented a new design configuration by utilizing the most effective aperture of the antenna, and eliminating the least effective area. Using this method, an antenna was designed at 18 GHz with a beam tilt angle of 30° and a total aperture of 10λ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> . The antenna has demonstrated a directivity of 25.9 dBic and a realized gain of 25.6 dBic at 18 GHz with a tilt angle of 30°. The far-field radiation pattern has shown a side lobe level of less than -21 dB.
SER GEJ JENSEN. (2012)

The article reviews a 2011 art exhibition featuring the paintings of Sergej Jensen held at the Galerie Neu in Berlin, Germany.
Do Vascular Surgeons Improve the Outcome of Carotid Endarterectomy? An Analysis of 12,618 Elective Cases in the State of Connecticut (2004)

Because cardiac complications may predict long-term survival after carotid endarterectomy (CEA), this study evaluates contemporary outcome, including cardiac complications, after CEA. Patients in Connecticut hospitals undergoing CEA between 1991 and 2002 were identified using the state discharge database (Chime, Inc.; <www.cthosp.org>). Of the 12,618 CEAs performed, there were 53 (0.4%) deaths, 155 (1.2%) neurologic complications, and 300 (2.4%) cardiac complications. Despite an increase in patient age (p < .0001, Kruskal-Wallis test) over time, there were decreases in mortality (p = .0001, chi-square), postoperative stroke (p = .001), and cardiac complications (p = .0003). Vascular surgeons performed a minority of the procedures in the state (11%), but there were fewer cardiac complications after CEA performed by vascular surgeons than general surgeons (0.8% vs 3.0%; p < .0001). Multivariable logistic regression demonstrated that the risk of a cardiac complication was elevated in patients operated on by a nonvascular surgeon, patients with previous heart disease or stroke, and the elderly. In a state with very high performance of CEA by general and nonvascular surgeons, postoperative mortality and neurologic complications remain low. However, there were fewer cardiac complications when a vascular surgeon performed the procedure. These results suggest that increased referral to vascular surgeons could improve procedural safety.
R-phycoerythrin proteins@ZIF-8 composite thin films for mercury ion detection (2019)

Mercury, as one of the most prevalent toxic metals released by various natural and anthropogenic processes, causes severe pollution of soil and groundwater. In this work, R-phycoerythrin (R-PE) proteins encapsulated into ZIF-8 composite thin films were prepared via a solid-confinement conversion process and applied as fluorescent sensors for mercury ion detection. The R-PE proteins encapsulated into ZIF-8 exhibit dual color emissions including green (518 nm) and red (602, 650 nm) fluorescence, while the original orange emission (578 nm) of pure R-PE is significantly suppressed. R-PE@ZIF-8 presents excellent selectivity and sensitivity for mercury detection in a large pH range without buffer solution. Under the optimal conditions, there is a good linear relationship between the fluorescence quenching efficiencies of R-PE@ZIF-8 and logarithmic concentrations of mercury ions in the range of 0.001-50 μM with the detection limit (LOD) of 6.7 nM much lower than the guideline value given by the World Health Organization. Furthermore, multi-peak detection of R-PE@ZIF-8 improves the detection accuracy of Hg<sup>2+</sup> concentration.
Convergent Algorithms for H2 Optimal Discrete Filter Reduction (1997)

This paper deals with an order reduction problem for a given full order filter associated with a stable discrete linear signal model. The reduced order filter is required to minimize the H2-norm of the filter- ing error transfer function rather than that of the crror between the full order filter and the reduced order filter. By an orthogonal parameterization, the above problem is formulated as minimising the filtering error variance over a set of orthogonal matrices. Two gradient based algorithms are derived to compute an optimal reduced order filter. The algorithms are very simple and more importantly, they possess nice properties, including the desirable convergence property. A numerical example is presented to demonstrate the effectiveness and sig- nificance of the proposed algorithms.
ChemInform Abstract: Effect of Additives on the Structure and Reactivity of the Surface Vanadium Oxide Phase in V2O5/TiO2 Catalysts. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison (2013)

Rilpivirine is a nonnucleoside reverse transcriptase inhibitor used to treat HIV-1. In the present study, the pathways responsible for the biotransformation of rilpivirine were defined. Using human liver microsomes, the formation of two mono- and two dioxygenated metabolites were detected via ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Mass spectral analysis of the products suggested that these metabolites resulted from oxygenation of the 2,6-dimethylphenyl ring and methyl groups of rilpivirine. Chemical inhibition studies and cDNA-expressed cytochrome P450 (CYP) assays indicated that oxygenations were catalyzed primarily by CYP3A4 and CYP3A5. Glucuronide conjugates of rilpivirine and a monomethylhydroxylated metabolite of rilpivirine were also detected and were found to be formed by UDP-glucuronosyltransferases (UGTs) UGT1A4 and UGT1A1, respectively. All metabolites that were identified in vitro were detectable in vivo. Further, targeted UHPLC-MS/MS-based in vivo metabolomics screening revealed that rilpivirine treatment versus efavirenz treatment may result in differential levels of endogenous metabolites, including tyrosine, homocysteine, and adenosine. Rilpivirine biotransformation was also assessed across species using liver microsomes isolated from a range of mammals, and the metabolite profile identified using human liver microsomes was largely conserved for both oxidative and glucuronide metabolite formation. These studies provide novel insight into the metabolism of rilpivirine and the potential differential effects of rilpivirine- and efavirenz-containing antiretroviral regimens on the endogenous metabolome.
Black tea aroma inhibited increase of salivary chromogranin-A after arithmetic tasks (2018)

Inhaling black tea aroma may diminish stress levels caused by arithmetic mental stress tasks, and Darjeeling tea aroma tended to improve mood before mental stress load.
Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer’s disease mouse model (2022)

Abstract Modulation of physical activity represents an important intervention that may delay, slow, or prevent mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD). One mechanism proposed to underlie the beneficial effect of physical exercise involves the apparent stimulation of adult hippocampal neurogenesis (AHN). BCI-838 is a pro-drug whose active metabolite BCI-632 is an antagonist at the group II metabotropic glutamate receptor (mGluR2/3). We previously demonstrated that administration of BCI-838 to a mouse model of cerebrovascular accumulation of oligomeric Aβ E22Q ( APP E693Q = “Dutch APP” ) reduced learning behavior impairment and anxiety, both of which are associated with the phenotype of the Dutch APP mice. Here we show that (i) administration of BCI-838, physical exercise, or a combination of BCI-838 and physical exercise enhanced AHN in a four-month old mouse model of AD amyloid pathology ( APP KM670/671NL / PSEN1 Δexon9 = APP/PS1), (ii) administration of BCI-838 alone or associated with physical exercise led to stimulation of AHN and improvement in both spatial and recognition memory, (iii) significantly, the hippocampal dentate gyrus transcriptome of APP/PS1 mice following BCI-838 treatment up-regulated brain-derived neurotrophic factor (BDNF), PIK3C2A of the PI3K-MTOR pathway, and metabotropic glutamate receptors, and down-regulated EIF5A of ketamine-modulating mTOR activity, and finally (iv) qPCR findings validate a significantly strong association between increased BDNF levels and BCI-838 treatment. Our study points to BCI-838 as a safe and orally active compound capable of mimicking the beneficial effect of exercise on AHN, learning behavior, and anxiety in a mouse model of AD neuropathology.
Residual Learning from Demonstration. (2020)

Contacts and friction are inherent to nearly all robotic manipulation tasks. Through the motor skill of insertion, we study how robots can learn to cope when these attributes play a salient role. In this work we propose residual learning from demonstration (rLfD), a framework that combines dynamic movement primitives (DMP) that rely on behavioural cloning with a reinforcement learning (RL) based residual correction policy. The proposed solution is applied directly in task space and operates on the full pose of the robot. We show that rLfD outperforms alternatives and improves the generalisation abilities of DMPs. We evaluate this approach by training an agent to successfully perform both simulated and real world insertions of pegs, gears and plugs into respective sockets.
Mission d'évaluation des possibilités de valorisation de la mangue en Haïti : rapport de mission effectuée du 15 au 27 juin 1998 (contrat N.321.2/98) (1998)

Parmi les productions agricoles d'Haïti le manguier tiendrait la seconde place en volume de production aprés le café et le cacao. Les estimations globales de la production varient considérablement en fonction des sources consultées : entre 90 000 et 400 000 tonnes par an. Ce rapport de mission s'inscrit dans ce contexte. Il s'intéresse particulièrement à la transformation de ce produit et à la commercialisation des produits transformés obtenus. Il a été réalisé à la demande des professionnels de cette filière en Haïti. Les quatre grands thèmes retenus par le Centre de développement industriel sont une évaluation de la production, en quantité et en qualité, une évaluation des possibilités de transformation et de développement, une analyse spécifique des possibilités de produits biologiques, et une proposition de développement de la transformation, en identifiant quelques entreprises suceptibles d'être aidées
Computationally efficient neuro-dynamic programming approximation method for the capacitated re-entrant line scheduling problem (2011)

Abstract This paper presents a computationally efficient neuro-dynamic programming approximation method for the capacitated re-entrant line scheduling problem by reducing the number of feature functions. The method is based on a statistical assessment of the significance of the various feature functions. This assessment can be made by combining the weighted principal components with a thresholding algorithm. The efficacy of the new feature functions selected is tested by numerical experiments. The results indicate that the feature selection method presented here can extract a small number of significant features with the potential capability of providing a compact representation of the target value function in a neuro-dynamic programming framework. Moreover, the linear parametric architecture considered holds considerable promise as a way to provide effective and computationally efficient approximations for an optimal scheduling policy that consistently outperforms the heuristics typically employed. Keywords: capacitated re-entrant linedata miningfeature selectionschedulingneuro-dynamic programmingprincipal component analysis Acknowledgement This work was supported by Grant Nos. 2009-0070818 and 2010-0003811 from the National Research Foundation of Korea and Brain Korea 21 (Network Enterprise). Notes Note 1. For the case of configuration 1, the reported percent errors are non-zero as in Table 4, which results from the randomising nature of the applied policy.
NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer (2020)

NF-κB is an antiapoptotic transcription factor that has been shown to be a mediator of treatment resistance. Bcl-3 is a regulator of NF-κB that may play a role in oncogenesis. The goal of this study was to correlate the activation status of NF-κB and Bcl-3 with clinical outcome in a group of patients with metastatic colorectal cancer (CRC).
THz plasmonic waves launchers for metamaterials studies (2010)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Coal derived porous carbon fibers with tunable internal channels for flexible electrodes and organic matter absorption (2015)

CPCFs with tunable internal channels were prepared<italic>via</italic>single-nozzle electrospinning, which exhibited excellent performance for energy storage and environmental protection.
Channel doping impact on FinFETs for 22nm and beyond (2012)

The natural choice to achieve multiple threshold voltages (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> ) in fully-depleted devices is by choosing the appropriate gate workfunction for each device. However, this comes at the cost of significantly higher process complexity. The absence of a body contact in FinFETs and insensitivity to back-gate bias leaves the conventional channel doping approach as the most practical technique to achieve multiple V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> . This choice, however, introduces a variable that is usually not considered in the context of fully depleted devices. For the first time, we demonstrate a multiple V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> solution at relevant device geometries and gate pitch for the 22nm node. We investigated the impact of FinFET channel doping on relevant device parameters such as T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">inv</inf> , mobility, electrostatic control and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> mismatch. We also show that V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> extraction by the “constant current” method could mislead the DIBL analysis of devices with greatly different channel mobility.
Automated Optimization of Aptamer Selection Buffer Conditions (2004)

Optimizing the buffer conditions of the selection of nucleic acid binding species (aptamers), increases the likelihood of producing a target aptamer. Aptamers, with high target affinity and specificity, are often compared to antibodies, as aptamers emerge in the industry as diagnostic and therapeutic tools. The increased demand for aptamers encourages high-throughput aptamer generation. The selection buffer conditions may vary as widely as the selection targets, and therefore buffer optimization is helpful if not required for effective aptamer selections. Such optimization work is time consuming and repetitious, which bodes well for high-throughput applications. To accommodate this, an automated buffer testing protocol has been developed to test target-to-unselected RNA pool binding in the presence of 96 different buffer conditions. The dynamic program may vary the monovalent salt(s) identity, monovalent salt(s) concentration, divalent salt(s) identity, divalent salt concentration, buffer identity, buffer concentration, and pH. The optimized buffer conditions likely increase the probability of a successful selection and therefore promote higher ratios of successful aptamer selections against a variety of targets. Preliminary results show trends with the buffer matrix solutions and lysozyme:unselected pool binding. In general, an inverse relationship between lysozyme binding and monovalent salt concentration is observed. (JALA 2004;9:117-22)
Gaining the Consent of the Governed: A Prerequisite to Peace in Northern Ireland (1994)

This address asserts that in seeking to resolve the political dilemma of Northern Ireland, the lesson of the U.S. Constitution is particularly relevant. The root of the political conflict in Northern Ireland is that, unlike in America, no consensus exists as to fundamental constitutional principles or the idea that the source of political authority is legitimately derived from the “consent of the governed.” The author argues that there is little hope of accommodation between the unionist and nationalist communities as long as the symbols of sovereignty and the structures of government administration serve or express the partisan agenda of one side only, whether unionist or nationalist. The principle of the consent of the governed, which is central to the U.S. Constitution, is the golden thread which may guide Northern Ireland out of the labyrinth.
Dectin-1 mediatesin vitrophagocytosis ofCandida albicansyeast cells by retinal microglia: Figure 1 (2011)

We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b(+) retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b(+) cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.
Efficacy and Safety of Dif1stat ® for the Treatment of Secondary Dyslipidemia in Chronic Kidney Disease (2013)

1104 patients with Secondary Dyslipidemia and CKD (Chronic Kidney Disease) (females: 387; males: 717; aged: 70 ± 11&#13;\nyears), were given Dif1stat® with diet to evaluate efficacy and safety. The study lasted two years. Patients were assigned to three&#13;\ngroups (A, B, C) based upon basal renal function. Group A consisted of 180 patients with GFR (glomerular filtration rate) of 67 ±&#13;\n16ml/min/m2. TC (Total-Cholesterol) (-31%), LDLC (LDL-Cholesterol) (-42%), TG (triglycerides) (-36.8%) levels, and nonHDLC&#13;\n(non HDLC holesterol) (-41%) and TC/HDLC ratio (-40%) were significantly reduced (P &lt; 0001). GFR (+2.5%) increased&#13;\nsignificantly. No significant changes were observed in HDLC (+13%). Group B was of 744 patients, 69% (males: 514), 31%&#13;\n(females: 230) (median age: 70 ± 13 years), and moderate stage III CKD (GFR: 38 ± 12 mL/min/1.73m2). After 24 months the&#13;\nchange of HDLC (+3.5%) was not significant, while TC (-27%), TG (-32%), LDLC (-33%), non-HDLC (33.4%), TC/HDLC (-30%),&#13;\nand GFR (+2.1%) were statistically significant (P &lt; 0.001). Group B consisted of 180 patients, 51.6% (males: 93), 48.3% (females:&#13;\n87) (median age: 72 ± 11 years), with severe stage IV CKD (GFR: 19 mL/min/1.73m2). HDLC (+13%) was not significant, while TC&#13;\n(-32%), TG (-38%), LDLC (-35%), non-HDLC (-38.5%), TC/HDLC (-40%), and GFR (+2.1%) were statistically significant (P &lt;&#13;\n0.001). An effective but safe lipid-lowering therapy in patients with CKD, may be crucial to prevent cardiovascular events. The&#13;\ntreatment with Dif1stat® combined with diet is to be started as soon as possible in patients with CKD in order of improving lipid and lipoprotein profile, and reducing the progression of renal damage.
Interference in finite-sized highly dense millimeter wave networks (2015)

The potential of millimeter wave (mmWave) frequencies for device-to-device communication among wearable electronics is enormous for applications requiring Gbps through-put. In a dense usage scenario such as inside a train car or airplane cabin, many devices may be present within close proximity where interference is significant. Previous work that models interference in wireless networks has leveraged stochastic geometry and often assumes an infinite number of interferers. In the indoor wearables setting, a finite network may be a more realistic assumption. This paper analyzes mmWave networks with a finite number of interferers that are located in fixed positions. The paper considers the effect of blockages, which are primarily caused by the human bodies present in the operating environment. Expressions for coverage and rate are developed, which capture the effects of key antenna characteristics such as directivity and gain.