gebhart/patrepeval huggingface dataset:
The European BOOM Project: Silicon Photonics for High-Capacity Optical Packet Routers (2010)

During the past years, monolithic integration in InP has been the driving force for the realization of integrated photonic routing systems. The advent of silicon as a basis for cost-effective integration and its potential blend with III-V material is now opening exciting opportunities for the development of new, high-performance switching and routing equipment. Following this rationale, BOOM-as a European research initiative-aims to develop compact, cost-effective, and power-efficient silicon photonic components to enable optical Tb/s routers for current and new generation broadband core networks. This “siliconization” of photonic routers is expected to enable ultrahigh bit rates as well as higher levels of integration and power efficiency. The BOOM “device portfolio” includes all-optical wavelength converters, ultradense wave-division multiplexing (UDWDM) photodetectors, and high-speed transmitters; all based on silicon waveguide substrates. Here, we present the device concepts, the fabrication of photonic building blocks and the experiments carried out as the initial steps toward the realization of the first high-capacity silicon photonic router.
Electric potential invariants and ions-in-molecules effective potentials for molecular Rydberg states (2016)

The dependence of multipole moments and polarizabilities on external fields appears in many applications including biomolecular molecular mechanics, optical non-linearity, nanomaterial calculations, and the perturbation of spectroscopic signatures in atomic clocks. Over a wide range of distances, distributed multipole and polarizability potentials can be applied to obtain the variation of atom-centered atoms-in-molecules electric properties like bonding-quenched polarizability. For cylindrically symmetric charge distributions, we examine single-center and atom-centered effective polarization potentials in a non-relativistic approximation for Rydberg states. For ions, the multipole expansion is strongly origin-dependent, but we note that origin-independent invariants can be defined. The several families of invariants correspond to optimized representations differing by origin and number of terms. Among them, a representation at the center of dipole polarizability optimizes the accuracy of the potential with terms through 1/r<sup>4</sup>. We formulate the single-center expansion in terms of polarization-modified effective multipole moments, defining a form related to the source-multipole expansion of Brink and Satchler. Atom-centered potentials are an origin independent alternative but are limited both by the properties allowed at each center and by the neglected effects like bond polarizability and charge flow. To enable comparisons between single-center effective potentials in Cartesian or spherical form and two-center effective potentials with differing levels of mutual induction between atomic centers, we give analytical expressions for the bond-length and origin-dependence of multipole and polarizability terms projected in the multipole and polarizability expansion of Buckingham. The atom-centered potentials can then be used with experimental data and ab initio calculations to estimate atoms-in-molecules properties. Some results are given for BaF<sup>+</sup> and HF showing the utility and limitations of the approach. More detailed results on X <sup>1</sup>Σ<sup>+</sup> CaF<sup>+</sup> are published separately.
Fluorescence-based optical chemical sensors for personal protection (2010)

The World Health Organization has reported that each year approximately 3 million people are poised by organophosphate substances (pesticides and nerve agents) resulting in 220,000 deaths. Organophosphates (OP) are toxic compounds which cause rapid and severe inhibition of serine proteases, most markedly acetylcholinesterase, which is vital to nerve function. This inhibition is often fatal. OP nerve agents are generally stable, easy to disperse, and highly toxic. They can be absorbed through the skin, by ingestion, or by respiration. A release of a nerve agent has the potential to rapidly affect a large number of people. The ease of manufacturing and dispensability of nerve agents, as well as available, inexpensive starting materials make these agents a weapon of choice for criminal terrorist attacks. One of the major steps toward protection against dangerous substances is to develop sensor devices that can act as an early warning system to the endangered people.
Flow experience in game based learning – a systematic literature review (2017)

The entertaining elements implemented in a serious game are key factors in determining whether a player will be engaged in a play-learn process and able to achieve the desired learning outcomes. Thus, optimization of subjective playing experience is a crucial part of a game design process. Flow theory can be adopted for measuring user experience and analyzing the quality of serious game designs. In addition, flow seems to have a positive influence on performance enhancement, learning and engagement. The focus of this review is especially on examining the meaning of flow in the context of serious games as well as exploring the relationship between flow and learning, factors that influence occurrence of flow and how flow is operationalized. The review revealed that there are mainly conceptual considerations about flow in serious games, but no robust empirical evidence about the meaning of flow. This is in line with other studies. We argue that research on flow should focus on the specific aspects related to the very nature of serious games that combine enjoyment and learning. Furthermore, new methods to measure flow and analyse the data need to be developed and studied.
Reliability of the University of Miami Chronic Rhinosinusitis Staging System (2006)

The UMCRSS is a comprehensive and reliable staging system with very strong and positive correlation between the CT and endoscopic components.
Cellular HTS Assays for Pharmacological Characterization of Na V 1.7 Modulators (2007)

Ion channels are challenging targets in the early phases of the drug discovery process, especially because of the lack of technologies available to screen large numbers of compounds in functionally relevant assays. The electrophysiological patch-clamp technique, which is the gold standard for studying ion channels, has low throughput and is not amenable to screening large numbers of compounds. However, for random high-throughput screening (HTS) of compounds against ion channel targets, a number of functional cellular assays have become available during the last few years. Here we use the sodium channel NaV1.7 stably expressed in human embryonic kidney 293 cells and compare three HTS assays-a Li flux atomic absorption spectroscopy (AAS) assay, a fluorescent imaging plate reader (FLIP, Molecular Devices, Sunnyvale, CA) membrane potential assay, and a fluorescence resonance energy transfer (FRET)-based membrane potential assay-to an automated electrophysiological assay (the Ionworks HT [Molecular Devices] platform) and characterize 11 known NaV inhibitors. Our results show that all three HTS assays are suitable for identification of NaV1.7 inhibitors, but as an HTS assay the Li-AAS assay is more robust with higher Z' values than the FLIPR and FRET-based membrane potential assays. Furthermore, there was a better correlation between the Ionworks assay and the Li-AAS assay regarding the potency of the NaV inhibitors investigated. This paper describes the first comparison between all the HTS assays available today to study voltage-gated NaVs, and the results suggest that the Li-AAS assay is more suited as a first HTS assay when starting an NaV drug discovery campaign.
On the tomographic reconstruction resolution from compressive holography (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Rivenson, A. Stern, and J. Rosen, "On the tomographic reconstruction resolution from compressive holography," in Imaging and Applied Optics, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper CW1C.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Impact Damage and Strain Rate Effects for Toughened Epoxy Composite Structures (2006)

Structural integrity of composite systems under dynamic impact loading is investigated herein. The GENOA virtual testing software environment is used to implement the effects of dynamic loading on fracture progression and damage tolerance. Combinations of graphite and glass fibers with a toughened epoxy matrix are investigated. The effect of a ceramic coating for the absorption of impact energy is also included. Impact and post impact simulations include verification and prediction of (1) Load and Impact Energy, (2) Impact Damage Size, (3) Maximum Impact Peak Load, (4) Residual Strength, (5) Maximum Displacement, (6) Contribution of Failure Modes to Failure Mechanisms, (7) Prediction of Impact Load Versus Time, and (8) Damage, and Fracture Pattern. A computer model is utilized for the assessment of structural response, progressive fracture, and defect/damage tolerance characteristics. Results show the damage progression sequence and the changes in the structural response characteristics due to dynamic impact. The fundamental premise of computational simulation is that the complete evaluation of composite fracture requires an assessment of ply and subply level damage/fracture processes as the structure is subjected to loads. Simulation results for the graphite/epoxy composite were compared with the impact and tension failure test data, correlation and verification was obtained that included: (1) impact energy, (2) damage size, (3) maximum impact peak load, (4) residual strength, (5) maximum displacement, and (6) failure mechanisms of the composite structure.
<title>Three-dimensional surface profilometry using structured liquid crystal grating</title> (1999)

This paper describes a device for measuring the three dimensional surface profile using a grating projection method. A phase shifting technique without any mechanical moving is expected for profile analysis. A grating that is a key component in this technique is made using an active controlled liquid crystal (LC). This LC grating has the performances of more than 8 bits of gray levels and its grating period is 50 micro-meters per line without any colored filters. Surface profiles of some samples are measured for the demonstration of the system.
[EEG topographic changes of brain abscesses in children]. (1987)

EEG topography was investigated before and after surgical treatment in 4 patients with brain abscess aged from 5 to 13 years. According to the recording technique designed by Matsuoka and Ueno, the recorded EEG for each 5 seconds was analyzed to obtain square roots of power spectra for each band of delta (2-3.8 Hz), theta (4-7.8 Hz) and alpha (8-12.8 Hz) which were then added for the 60-seconds duration of each trial. After that, numerical matrix presenting the topographic distribution of spectral energy of each band were constructed and displayed as color images. In addition, the EEG topographies of brain abscesses were compared with the CT scans simultaneously obtained. In all of four cases before surgical treatment of the brain abscess, the location of the focal delta wave on the EEG topography was more closely related to the site of brain abscess comparing with its correlation between the location of the delta focus on the conventional EEG and the site of brain abscess. In contrast, as for the theta wave, there was no prominent correlation to the site of the brain abscess. In the early stage of 10-15 days after aspiration of the brain abscess, the most characteristic change of the EEG topography was an approximately 25% reduction of the maximum equivalent voltage of delta band with associated disappearance of the sharply located focal delta wave being noted before aspiration.(ABSTRACT TRUNCATED AT 250 WORDS)
Mobi3DSketch (2019)

Mid-air 3D sketching has been mainly explored in Virtual Reality (VR) and typically requires special hardware for motion capture and immersive, stereoscopic displays. The recently developed motion tracking algorithms allow real-time tracking of mobile devices, and have enabled a few mobile applications for 3D sketching in Augmented Reality (AR). However, they are more suitable for making simple drawings only, since they do not consider special challenges with mobile AR 3D sketching, including the lack of stereo display, narrow field of view, and the coupling of 2D input, 3D input and display. To address these issues, we present Mobi3DSketch, which integrates multiple sources of inputs with tools, mainly different versions of 3D snapping and planar/curves surface proxies. Our multimodal interface supports both absolute and relative drawing, allowing easy creation of 3D concept designs in situ. The effectiveness and expressiveness of Mobi3DSketch are demonstrated via a pilot study.
Bidirectional multi-symbol phase estimation scheme for optical communications (2014)

A bidirectional multi-symbol phase estimation (BD-MSPE) scheme for differentially encoded optical signals, which can realize high-speed processing with superior BER characteristics, is proposed. Conventional MSPE needs decision feedback to correct phases of past symbols, so it is not suitable for parallelization. BD-MSPE, in contrast, uses tentative decision to avoid feedback. Due to the tentative decision, both past and future symbols can be utilized for phase estimation. Moreover, BD-MSPE can be organized in multistage when the decision result of the first stage of MSPE is used as the second tentative decision result for the next stage. Simulation results show the bit-error-rate (BER) curve of the proposed scheme asymptotically approaches that obtained by coherent detection.
Restriction fragment length polymorphism analysis of variation in Fusarium species causing ear blight of cereals (1993)

Genetic variation in Fusarium species on wheat was investigated using restriction fragment length polymorphism (RFLP) analysis. Single‐spore lines (76) of Fusarium were recovered from 24 ears of wheat in a field plot exhibiting severe symptoms of Fusarium ear blight and identified using classical taxonomic criteria. Four Fusarium species were present, of which F. avenaceum and F. culmorum were predominant with F. lateritium and F. poae present in two ears and one ear, respectively. RFLP analysis using rDNA (pTA71) or total genomic DNA from an F. culmorum isolate clearly distinguished the four species. Genetic fingerprints of the isolates generated using DNA of bacteriophage M13 (which contains a mini‐satellite repeat sequence) revealed considerable variation within three of the four species (except F. poae). Generally, only a single clone was recovered from each ear and in all but one case only a single species was obtained from each spikelet. However, in several instances it appeared that more than one clone of a species was present within a single spikelet.
Selective and Mutational Patterns Associated With Gene Expression in Humans (2004)

We report the results of a comprehensive study of the influence of gene expression on synonymous codons, amino acid composition, and intron presence and size in human protein-coding genes. First, in addition to a strong effect of isochores, we have detected the influence of transcription-associated mutational biases (TAMB) on gene composition. Genes expressed in different tissues show diverse degrees of TAMB, with genes expressed in testis showing the greatest influence. Second, the study of tissues with no evidence of TAMB reveals a consistent set of optimal synonymous codons favored in highly expressed genes. This result exposes the consequences of natural selection on synonymous composition to increase efficiency of translation in the human lineage. Third, overall amino acid composition of proteins closely resembles tRNA abundance but there is no difference in amino acid composition in differentially expressed genes. Fourth, there is a negative relationship between expression and CDS length. Significantly, this is observed only among genes with introns, suggesting that the cause for this relationship in humans cannot be associated only with costs of amino acid biosynthesis. Fifth, we show that broadly and highly expressed genes have more, although shorter, introns. The selective advantage for having more introns in highly expressed genes is likely counterbalanced by containment of transcriptional costs and a minimum exon size for proper splicing.
Real-Time Quantitative PCR Assays for Detection andMonitoring of Pathogenic Human Viruses in ImmunosuppressedPediatricPatients (2004)

A panel of 23 real-time PCR assays based on TaqMan technology has been developed for the detection and monitoring of 16 different viruses and virus families including human polyomaviruses BK virus and JC virus, human herpesviruses 6, 7, and 8, human adenoviruses, herpes simplex viruses 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, parvovirus B19, influenza A and B viruses, parainfluenza viruses 1 to 3, enteroviruses, and respiratory syncytial virus. The test systems presented have a broad dynamic range and display high sensitivity, reproducibility, and specificity. Moreover, the assays allow precise quantification of viral load in a variety of clinical specimens. The ability to use uniform PCR conditions for all assays permits simultaneous processing and detection of many different viruses, thus economizing the diagnostic work. Our observations based on more than 50,000 assays reveal the potential of the real-time PCR tests to facilitate early diagnosis of infection and to monitor the kinetics of viral proliferation and the response to treatment. We demonstrate that, in immunosuppressed patients with invasive virus infections, surveillance by the assays described may permit detection of increasing viral load several days to weeks prior to the onset of clinical symptoms. In virus infections for which specific treatment is available, the quantitative PCR assays presented provide reliable diagnostic tools for timely initiation of appropriate therapy and for rapid assessment of the efficacy of antiviral treatment strategies.
Effect of ranolazine administered after trastuzumab treatment on cardiotoxicity in mice. (2015)

597 Background: Trastuzumab (T), a monoclonal antibody against ErbB2, has improved the prognosis of breast cancer patients, but ErbB2 blockade in cardiomyocytes can produce asymptomatic left ventricular dysfunction and heart failure, whose mechanism has not been elucidated and can include changes in Ca2+ regulation. We aim at assessing whether Ranolazine (R), an inhibitor of the late sodium current, administered after T treatment, blunts T cardiotoxicity in vivo and in vitro. Methods: In vitro, rat H9C2 cardiomyoblasts were treated with T (0.2µM) for 3 days and then treated in the absence or presence of R (1µM or 10μM) for 3 days. In vivo, fractional shortening (FS) and ejection fraction (EF) were measured by M-mode echocardiography and radial and longitudinal strain (RS and LS) were measured using 2D speckle-tracking, in C57/BL6 mice, at 0, 2 and after 7 days of daily administration of T (2.25 mg/kg/day). These measurements were repeated after 5 days of R treatment (305 mg/Kg/day) initiated at the end of T treatment. We have divided mice in 4 groups. The first group (G1) was treated with T for 7 days. The second group (G2) was treated with T for 7 days and then treated with R for 5 days. The other 2 were control groups: CG1 (sham) and CG2 (no R). We have evaluated tissue expression of BNP (brain natriuretic peptide) by PCR analysis on heart tissue. Results: R reduced T toxicity in H9C2 cardiomyoblasts as evidenced by higher percentage of viable cells treated with T+ R with respect to cells treated with T alone (p< 0.01). In vivo, after 7 days with T, FS decreased to 48.7 ± 4.1%, p< 0.01 vs 62.3 ± 0.8% (sham), EF to 81.8 ± 3.5%, p < 0.01 versus 91.7 ± 0.5% (sham), RS to 21 ± 8.1%, p < 0.01 versus 43.2 ± 4% (sham), and LS to -11 ± 3.7%, p < 0.01 versus -38.8 ± 6% (sham). In mice treated with R for 5 days after T treatment, the indices of cardiac function recovered: FS was 61 ± 1.2%, EF was 91 ± 0.7%, p < 0.01; RS was 35±1.8%, p < 0.05 versus T. However the alteration of LS persisted after treatment with R (-15.4 ± 5.1%, p = 0.3 vs. T). R prevents the increased expression of BNP (p < 0.05) on heart tissue Conclusions: R post-treatment blunts cardiotoxic effects due to T both in vitro and in vivo in a mouse model, as demonstrated by the normalization of the values of FS, EF and RS. LS is the first to impair and may be the last to recover.
Effect of SiC particle morphology on Co–P electroless coating characteristics (2015)

In this study, two kinds of micrometre sized SiC powders (as received and ball milled) were used as the starting materials to investigate the effect of ceramic surface morphology on the coating characteristics. Determined optimised electroless deposition bath values of pH (9) and bath temperature (70°C) were used. It was found that etching pretreatment was very effective on the coating quality for both types of SiC powders. The experimental results indicated that milling of the powders led to the formation of multimodal sized ceramic powders with sharp edges and rough surfaces, which resulted in a uniform adhesive metallic layer on the powders without any crack formation. Finally, the effect of cobalt coating on the incorporation of ceramic particles into the molten aluminium during fabrication of aluminium matrix composite was studied, and it was revealed that a significant improvement in incorporation could be obtained using cobalt coated ceramic particles.
Bacterial Cell–Cell Communication in the Host via RRNPP Peptide-Binding Regulators (2016)

Human microbiomes are composed of complex and dense bacterial consortia. In these environments, bacteria are able to react quickly to change by coordinating their gene expression at the population level via small signaling molecules. In Gram-positive bacteria, cell-cell communication is mostly mediated by peptides that are released into the extracellular environment. Cell-cell communication based on these peptides is especially widespread in the group Firmicutes, in which they regulate a wide array of biological processes, including functions related to host-microbe interactions. Among the different agents of communication, the RRNPP family of cytoplasmic transcriptional regulators, together with their cognate re-internalized signaling peptides, represents a group of emerging importance. RRNPP members that have been studied so far are found mainly in species of bacilli, streptococci, and enterococci. These bacteria are characterized as both human commensal and pathogenic, and share different niches in the human body with other microorganisms. The goal of this mini-review is to present the current state of research on the biological relevance of RRNPP mechanisms in the context of the host, highlighting their specific roles in commensalism or virulence.