gebhart/patrepeval huggingface dataset:
Evaluation of the impact of sulfuryl fluoride fumigation and heat treatment on stored-product insect populations in UK flour mills. (2009)

A study was carried out to compare the impact of a sulfuryl fluoride (ProFume™, Dow AgroSciences LLC) fumigation and a heat treatment upon populations of the rust red flour beetle (Tribolium castaneum), the confused flour beetle (Tribolium confusum) and the Mediterranean flour moth (Ephestia kuehniella) in UK flour mills. One mill was selected for fumigation with sulfuryl fluoride and was monitored for flour beetles and one mill was selected for heat treatment and was monitored for both flour beetles and moths. Traps baited with aggregation pheromone lure and an oil-based food attractant were used to monitor populations of rust red flour beetle and confused flour beetle. For the monitoring of Mediterranean flour moth, sticky traps baited with a pheromone lure were used. Traps were placed inside the mill buildings within the areas selected for treatment. Populations of stored products insects were monitored in these flour mills for 8 weeks prior to and 12 weeks following treatment.
A Review of the ASW Model in ITEM (2005)

Abstract : This is a brief, technical review of the Anti-Submarine Warfare (ASW) part of ITEM, a widely used theater combat model. Several apparent deficiencies are pointed out. The recommendation is that ITEM's documentation be improved, and that a more extensive verification be carried out.
Branch point evolution controls species-specific alternative splicing and regulates long term potentiation (2022)

Abstract Regulation and functionality of species-specific alternative splicing has remained enigmatic to the present date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants and plays a key role in learning and memory. Here, we identify and characterize several primate-specific CAMK2B splice isoforms, which show altered kinetic properties and changes in substrate specificity. Furthermore, we demonstrate that primate-specific Camk2β alternative splicing is achieved through branch point weakening during evolution. We show that reducing branch point and splice site strengths during evolution globally renders constitutive exons alternative, thus providing a paradigm for cis -directed species-specific alternative splicing regulation. Using CRISPR/Cas9 we introduced a weaker human branch point into the mouse genome, resulting in human-like CAMK2B splicing in the brain of mutant mice. We observe a strong impairment of long-term potentiation in CA3-CA1 synapses of mutant mice, thus connecting branch point-controlled, species-specific alternative splicing with a fundamental function in learning and memory.
Parallelism in Manipulator Dynamics (1985)

This paper addresses the problem of efficiently computing the motor torques required to drive a manipulator arm in free motion, given the desired trajectory—that is the inverse dynamics problem. It analyzes the high degree of parallelism inherent in the computations and presents two "mathemati cally exact "formulations especially suited to high-speed, highly parallel implementations using VLSI devices. The first method presented is a parallel version of the recent linear Newton-Euler recursive algorithm. The time cost is linear in the number of joints, but the real-time coefficients are re duced by almost two orders of magnitude. The second formu lation reports a new parallel algorithm that shows that it is possible to improve on the linear time dependency. The real time required to perform the calculations increases only as the [ log 2 ] of the number of joints. Either formulation is sus ceptible to a systolic pipelined architecture in which complete sets of joint torques emerge at successive intervals of four floating-point operations. Hardware requirements necessary to support the algorithm are not excessive, and a VLSI im plementation architecture is possible.
New focusing multilayer structures for X-ray plasma spectroscopy (2008)

New focusing short-period multilayer structures are developed which opens up wide possibilities for X-ray and VUV spectroscopy. Multilayer structures are deposited on a flat surface of a mica crystal which is then bent to a small-radius cylinder. The use of this structure in a von Hamos spectrometer for X-ray laser plasma diagnostics is demonstrated.
Subtyping recursive types in kernel Fun (2003)

The problem of defining and checking a subtype relation between recursive types was studied in Armadio and Cardelli (1993) for a first order type system, but for second order systems, which combine subtyping and parametric polymorphism, only negative results are known. This paper studies the problem of subtype checking for recursive types in system kernel Fun, a typed /spl lambda/-calculus with subtyping and bounded second order polymorphism. Along the lines of Armadio and Cardelli (1993), we study the definition of a subtype relation over kernel Fun recursive types, and then we present a subtyping algorithm which is sound and complete with respect to this relation. We show that the natural extension of the techniques introduced in Armadio and Cardelli (1993) to compare first order recursive types gives a non complete algorithm. We prove the completeness and correctness of a different algorithm, which also admits an efficient implementation.
The concentration dependence of the self‐diffusion coefficients of strontium ion in aqueous polystyrenesulfonic acid solutions (1960)

Abstract The diffusion coefficients of strontium in 10 −4 M aqueous solutions of polystyrenesulfonic acid were measured at 26°C. The coefficients were low, about 0.15 X 10 −5 cm. 2 /sec., until strontium equivalent to one‐fifth of the sulfonates had been added. They then increased relatively rapidly, to about 0.7 X 10 −5 cm. 2 /sec., as the concentration of strontium was increased to 10 −4 M . These results are interpreted to mean either that the binding of counterions to a polyelectrolyte is limited to parts of a chain and is not related to the chain as a whole, or else that there is a recurring regularity of structure in the atactic polystyrene sulfonic acid which limits binding of counterions to a fraction of the total charged sites.
Stereoselective synthesis and biological activities of diethyl (E)‐{[4‐cyano‐5‐[[(disubstitutedamino)methylene]amino]‐3‐(methylthio)‐ 1H‐pyrazol‐1‐yl]substituited phenylmethyl}phosphonates (2009)

Abstract magnified image Diethyl {[5‐amino‐4‐cyano‐3‐(methylthio)‐1 H ‐pyrazol‐1‐yl]substitutedphenylmethyl}phosphonates 3 were efficiently synthesized via the condensation of [(1‐hydrazino)substitutedphenylmethyl]phosphonates 1 with 2‐[bis(methylthio)methylene]malononitrile 2 . 3 reacted with triethyl orthoformate to afford diethyl ( E )‐{[4‐cyano‐5‐[(ethoxymethylene)amino]‐3‐(methylthio)‐1 H ‐pyrazol‐1‐yl]substitutedphenylmethyl}phosphonates 4 , which reacted with various secondary amines at room temperature to provide the target compounds 5 in good yields. Their structures were confirmed by ir, 1 H and 31 P NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassay indicated that compounds 5 possess potent herbicidal activity against the roots of dicotyledonous (oil rape) plants at the dosage of 100 mg/L, and compounds 5c and 5g exhibit 80.8% and 76.7% inhibitory activity against Colletotrichum gossypi at the concentration of 50 mg/L, respectively. Abstract end data: J. Heterocyclic Chem., 46, 555 (2009).
Évolution de l'activité métabolique du tissu adipeux de la chèvre au cours des 2 premiers mois de lactation. Relation avec la sécrétion lactée (1979)

Le poids de l’épiploon (rapporté au DNA) de 5 chèvres en 9e semaine de lactation est en relation inverse avec la quantité de lait produite au cours des 2 premiers mois de lactation. Cette relation semble résulter d'un dépôt de lipides dans le tissu adipeux, d’autant plus précoce que les animaux produisent moins de lait. L’activité de 4 enzymes lipogéniques et la monoinsaturation des acides gras de l’épiploon tendent par ailleurs à augmenter chez 4 des 5 chèvres, entre la 3e et la 9e semaine de lactation.
INFLUENCE OF SEXTANT PROSTATE NEEDLE BIOPSY OR SURGERY ON THE DETECTION AND HARVEST OF INTACT CIRCULATING PROSTATE CANCER CELLS (1999)

Prostate cancer cells can be harvested from men with clinically localized disease undergoing sextant needle biopsy or radical prostatectomy. Routine prostate biopsy and surgery may influence the number of measurable circulating cells in the short term but the clinical significance and long-term prevalence of detectable circulating cells are unknown. Further studies are needed to evaluate the clinical usefulness of this assay for detecting, staging and monitoring prostate cancer.
Atypical Patterns of Neural Infection Produced in Mice by Drugresistant Strains of Herpes Simplex Virus (1982)

Mice inoculated intracerebrally (i.c.) with a mutant strain of HSV were found to develop cataracts 1 to 2 months after inoculation. Cataract formation was subsequently shown to follow an acute retinitis which commenced within 1 week of inoculation. The mutant had been selected for high resistance to the nucleoside analogue acyclovir and has been shown previously to be defective in the induction of thymidine kinase and also to express an altered DNA polymerase. The LD50 for mice inoculated i.c. was greater than 10(5) p.f.u. compared with approx 7 p.f.u. for the parental strain. Studies of virus replication following i.c. inoculation with a sublethal dose of the mutant revealed that only small amounts of infectious virus were produced in the brain, but during a period from 6 to 12 days after inoculation vigorous replication occurred in retinal tissue, producing very high titres of virus.
Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction (2019)

The development of an intermolecular and enantioselective aza-Wacker reaction is described. Using indoles as the N-source and a selection of alkenols as the coupling partners selective β-hydride elimination toward the alcohol was achieved. This strategy preserves the newly formed stereocenter by preventing the formation of traditionally observed enamine products. Allylic and homoallylic alcohols with a variety of functional groups are compatible with the reaction in high enantioselectivity. Isotopic-labeling experiments support a syn amino-palladation mechanism for this new class of aza-Wacker reactions.
A calibration test of Stewart platform (2007)

A whole calibration test process of Stewart platform including the error analysis, calibration model, measure process, data analysis, parameter errors determination and the iterative result analysis is presented.
Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry" (2008)

Endogenous peptide sequences extracted from a 68-million-year-old Tyrannosaurus rex fossil bone and obtained by mass spectrometry have been shown to be statistically significant based on protein database searches using two different search engines and similarity comparisons to authentic tandem mass spectrometry spectra. Specifically, we have validated the sequence GVVGLP (OH) GQR.
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment (2022)

The testis is the second most frequent extramedullary site of relapse in pediatric acute lymphoblastic leukemia (ALL). The mechanism for B-cell (B) ALL cell migration towards and survival within the testis remains elusive. Here, we identified CXCL12-CXCR4 as the leading signaling axis for B-ALL cell migration and survival in the testicular leukemic niche. We combined analysis of primary human ALL with a novel patient-derived xenograft (PDX)-ALL mouse model with testicular involvement. Prerequisites for leukemic cell infiltration in the testis were prepubertal age of the recipient mice, high surface expression of CXCR4 on PDX-ALL cells, and CXCL12 secretion from the testicular stroma. Analysis of primary pediatric patient samples revealed that CXCR4 was the only chemokine receptor being robustly expressed on B-ALL cells both at the time of diagnosis and relapse. In affected patient testes, leukemic cells localized within the interstitial space in close proximity to testicular macrophages. Mouse macrophages isolated from affected testes, in the PDX model, revealed a macrophage polarization towards a M2-like phenotype in the presence of ALL cells. Therapeutically, blockade of CXCR4-mediated functions using an anti-CXCR4 antibody treatment completely abolished testicular infiltration of PDX-ALL cells and strongly impaired the overall development of leukemia. Collectively, we identified a prepubertal condition together with high CXCR4 expression as factors affecting the leukemia permissive testicular microenvironment. We propose CXCR4 as a promising target for therapeutic prevention of testicular relapses in childhood B-ALL. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Microfluidic hydrogels for tissue engineering (2011)

With advanced properties similar to the native extracellular matrix, hydrogels have found widespread applications in tissue engineering. Hydrogel-based cellular constructs have been successfully developed to engineer different tissues such as skin, cartilage and bladder. Whilst significant advances have been made, it is still challenging to fabricate large and complex functional tissues due mainly to the limited diffusion capability of hydrogels. The integration of microfluidic networks and hydrogels can greatly enhance mass transport in hydrogels and spatiotemporally control the chemical microenvironment of cells, mimicking the function of native microvessels. In this review, we present and discuss recent advances in the fabrication of microfluidic hydrogels from the viewpoint of tissue engineering. Further development of new hydrogels and microengineering technologies will have a great impact on tissue engineering.
Organometallic‐Mediated Radical Polymerization: Developing Well‐Defined Complexes for Reversible Transition Metal‐Alkyl Bond Homolysis (2009)

Abstract Organometallic‐mediated radical polymerization (OMRP) has emerged as a powerful new class of living controlled radical polymerization. In order to fulfill its potential in the polymerization of vinyl acetate (VOAc) and other challenging monomers, the effects of ancillary ligands on the metal‐alkyl bond dissociation energy in OMRP reagents must be thoroughly explored. Recent results investigating structure‐activity relationships in well‐defined cobalt, iron and chromium complexes will be discussed. The involvement of radical intermediates in oxidative addition of secondary alkyls for catalytic cross‐coupling reactions catalyzed by first row transition metals will also be examined for relevant design concepts. magnified image
Methoxy-P-Benzoquinone and Methoxyhydroquinone As Models for Chromophore Changes in the Bleaching of Softwood mechanical pulps. II. The Effect of Peroxide Charge, Reaction Ph, and Transition Metal Ions (1983)

Abstract Methoxy-p-benzoquinone and methoxyhydroquinone were reacted with-hydrogen peroxide in the presence of either Na5 DTPA/Mg2+ or silicate/Mg2+ stabilization systems. The conditions used approximated those in the technical bleaching process, and the resulting effect on color was ascertained by monitoring the absorbance at 457 nm. The results revealed that the initial color of solutions of the quinone and hydroquinone increased dramatically with the application of relatively small amounts of alkaline peroxide and was “bleached” to its original level only after application of excessively large amounts of this oxidant. Subsequent experimentation, in which the pH of the of the reaction mixture, order of reagent addition and mixing regimen were varied, provided evidence suggesting that the observed increase in “color” on alkaline peroxide treatment of the quinone was attributable to alkali-promoted condensation reactions, the products of which were only partly decolorized through action of the peroxide. The effect on “color” produced by the addition of transition metal ions was found to depend on the particular metal and the peroxide stabilization system employed. The responses of the quinone/hydroquinone and mechanical pulps toward alkaline peroxide in terms of optical properties are compared.
III–V/II–VI heterovalent double quantum wells (2006)

Abstract We report on design, fabrication by molecular beam epitaxy, and photoluminescence (PL) studies of III–V/II–VI heterovalent structures containing a GaAs/AlGaAs/ZnSe/ZnCdMnSe double quantum well (QW). The studies of temperature‐dependent and time‐resolved PL have provided an insight into the nature of the exciton localization potential induced by the heterovalent interface. It is found that under the resonant conditions the observed emission mostly originates from the recombination of excitons confined in type II quantum‐dot‐like structures, where the holes are localised within the GaAs QW due to the well width fluctuations and the electrons are localized in the plane of the ZnCdMnSe QW due to the fluctuations of the conduction band offset at the heterovalent interface, induced by random variation of the interface microscopic structure. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Authentication and integrity in outsourced databases (2006)

In the Outsourced Database (ODB) model, entities outsource their data management needs to a third-party service provider. Such a service provider offers mechanisms for its clients to create, store, update, and access (query) their databases. This work provides mechanisms to ensure data integrity and authenticity for outsourced databases. Specifically, this article provides mechanisms that assure the querier that the query results have not been tampered with and are authentic (with respect to the actual data owner). It investigates both the security and efficiency aspects of the problem and constructs several secure and practical schemes that facilitate the integrity and authenticity of query replies while incurring low computational and communication costs.
Derepressed Hyphal Growth and Reduced Virulence in a VH1 Family-related Protein Phosphatase Mutant of the Human PathogenCandida albicans (1997)

Mitogen-activated protein (MAP) kinases are pivotal components of eukaryotic signaling cascades. Phosphorylation of tyrosine and threonine residues activates MAP kinases, but either dual-specificity or monospecificity phosphatases can inactivate them. The Candida albicans CPP1 gene, a structural member of the VH1 family of dual- specificity phosphatases, was previously cloned by its ability to block the pheromone response MAP kinase cascade in Saccharomyces cerevisiae. Cpp1p inactivated mammalian MAP kinases in vitro and acted as a tyrosine-specific enzyme. In C. albicans a MAP kinase cascade can trigger the transition from the budding yeast form to a more invasive filamentous form. Disruption of the CPP1 gene in C. albicans derepressed the yeast to hyphal transition at ambient temperatures, on solid surfaces. A hyphal growth rate defect under physiological conditions in vitro was also observed and could explain a reduction in virulence associated with reduced fungal burden in the kidneys seen in a systemic mouse model. A hyper-hyphal pathway may thus have some detrimental effects on C. albicans cells. Disruption of the MAP kinase homologue CEK1 suppressed the morphological effects of the CPP1 disruption in C. albicans. The results presented here demonstrate the biological importance of a tyrosine phosphatase in cell-fate decisions and virulence in C. albicans.
Coherent Brightfield Microscopy Provides the Spatiotemporal Resolution To Study Early Stage Viral Infection in Live Cells (2017)

Viral infection starts with a virus particle landing on a cell surface followed by penetration of the plasma membrane. Due to the difficulty of measuring the rapid motion of small-sized virus particles on the membrane, little is known about how a virus particle reaches an endocytic site after landing at a random location. Here, we use coherent brightfield (COBRI) microscopy to investigate early stage viral infection with ultrahigh spatiotemporal resolution. By detecting intrinsic scattered light via imaging-based interferometry, COBRI microscopy allows us to track the motion of a single vaccinia virus particle with nanometer spatial precision (<3 nm) in 3D and microsecond temporal resolution (up to 100,000 frames per second). We explore the possibility of differentiating the virus signal from cell background based on their distinct spatial and temporal behaviors via digital image processing. Through image postprocessing, relatively stationary background scattering of cellular structures is effectively removed, generating a background-free image of the diffusive virus particle for precise localization. Using our method, we unveil single virus particles exploring cell plasma membranes after attachment. We found that immediately after attaching to the membrane (within a second), the virus particle is locally confined within hundreds of nanometers where the virus particle diffuses laterally with a very high diffusion coefficient (∼1 μm<sup>2</sup>/s) at microsecond time scales. Ultrahigh-speed scattering-based optical imaging may provide opportunities for resolving rapid virus-receptor interactions with nanometer clarity.
Intravascular metabolism of lipid emulsions with different fatty acid pattern: influence on fatty acid profile of membrane phospholipids in target organs and cells (2011)

\
Mediators of physical exercise for improvement in cancer survivors' quality of life (2013)

The beneficial effect of group-based physical exercise on QoL was mediated by increased physical activity, general self-efficacy and mastery, and subsequent reductions in fatigue and distress. In addition to physical activity, future interventions should target self-efficacy and mastery. This may lead to reduced distress and fatigue, and consequently improved QoL of cancer survivors.
An investigation of the active area of a small semiconductor particle detector (1981)

A slice of silicon with specially patterned electrodes on each side was fabricated in an effort to make a particle radiation detector with a small active area. The active area was mapped out with the aid of a narrow collimated beam of van de Graaff generated protons and the area thus found is compared with the shapes of the electrodes on the faces of the slice. An attempt was made, by altering the bias condition on the electrodes, to improve the coincidence between the active area and the electrodes.
D'Nealian Manuscript: A Continuous Stroke Print. (1975)

Citing five drawbacks to the traditional sticks anJ balloons method of printing used in beginning handwriting instruction, this pamphlet proposes instead the use of the DINealian continuous stroke printing method. The pamphlet contains arguments for using the method with learning disabled and dyslexic students, suggestions for developing a D,Nealian program, a discussion of the mechanics of writing, and suggestions for the timing and method for introducing small and cabital 1 tte s to students. Charts illustrating the differences in the 'traditional and D'Nealian manuscript methods and showing the relationship between D,Nealian and cursive writing are included. (FL) **** ********************* ******* * ********** ** * *** Rebroductions supplied by ERRS are the best that can be made from the original document. ******* ********* ******************** *** * ** 4 US CEPARTMENT OF WEALTH. 'EDUCATION A WELFARE NATIONAL INISTITUTE OF EDUCATION TNIS DDCUMEN' riAS SEEN REPRO. OUCED EXACTLY AS RECEIVED 'ADM TOIC PEWSON OR ORGAAIIZATION ORIGINATING IT POINTS OF VIEW OR OPINIONS STATED OQ NOT NECESSARILY REPRESENT OF.'ICIAL NATIONAL ThIST/TUTE OF EDUCATION POSfITION OR POLICY D1NEALIAN MANUSCRIPT A CONTINUOUS STROKE PRINT Donald N. Thurber ibraltar Schools Ro kw:,od, Michigan rim t-32, ofj J REPPODUCE TWS '1-'41.FRI,L HAS nEEN GRANTED BY