gebhart/patrepeval huggingface dataset:
1071-P: Long-Term Renin-Angiotensin System Inhibitor Use and Risk of Pneumonia and Pneumonia-Related Death in Type 2 Diabetes (2021)

Introduction: Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are renin angiotensin system inhibitors (RASi) which can reduce the proinflammatory-vasoconstricting activity of ACE/angiotensin II and enhance the anti-inflammatory-vasodilatory activity of ACE2/angiotensin 1-7. These drugs may be protective across a range of respiratory infections including bacterial and viral pneumonias. We examined long-term use of ACEi/ARBs on the risk of first pneumonia hospitalization and pneumonia-related death in Chinese patients with type 2 diabetes (T2D). Methods: Prospective analysis of 16,285 Chinese T2D patients with new RASi use observed between 2001 and 2019. Overlap weighting was performed to balance baseline characteristics. We used time-dependent Cox model to estimate the hazard ratio (HR) of outcomes while adjusting for the time-varying covariates. Results: There were 6,379 (39.2%) ACEi-users only, 4,065 (25.0%) ARBs-users and 5,841 (35.9%) non RASi-users. During a median observation of 7.6 years, 6.1% had first pneumonia hospitalization, 1.3% died during or within one month of pneumonia hospitalization and 17.6% died from other causes. No association was observed between RASi use and first pneumonia hospitalization. However, RASi-users had lower risk for pneumonia-related death (HR 0.51, 95% CI 0.35-0.76) than non-users [ACEi-users only: HR 0.53 (0.34-0.81); ARBs-users: HR 0.58 (0.32-1.04)]. We also noted reduced risk for all-cause death in RASi-users (HR 0.60, 95% CI 0.54-0.67) [ACEi-users only: HR 0.61 (0.54-0.69); ARBs-users: HR 0.67 (0.57-0.79)]. Conclusions: Long-term use of RASi was associated with reduced risk of pneumonia-related death and all-cause death, but not first pneumonia hospitalization, in Chinese patients with T2D. Relevance to other respiratory infections such as coronavirus-disease 2019 (COVID-19) merits further investigation. Disclosure M. Shi: None. E. Chow: Research Support; Self; Medtronic, Speaker’s Bureau; Self; Novartis Pharmaceuticals Corporation, Sanofi-Aventis. A. Yang: None. E. S. H. Lau: None. H. Wu: None. B. Fan: None. A. P. Kong: Advisory Panel; Self; Lilly Diabetes, Speaker’s Bureau; Self; Abbott, AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., Lilly Diabetes, Sanofi, Stock/Shareholder; Self; Aptorum. A. Luk: None. R. C. Ma: Other Relationship; Self; AstraZeneca, Medtronic, Research Support; Self; AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., Novo Nordisk, Pfizer Inc., Sanofi-Aventis, Tricida, Inc. J. C. Chan: Consultant; Self; Bayer AG, Boehringer Ingelheim International GmbH, MSD Corporation, Sanofi, Other Relationship; Self; Asia Diabetes Foundation, GemVCare, Research Support; Self; Applied Therapeutics, AstraZeneca, Hua Medicine, Lilly Diabetes, Merck KGaA.
Age-dependent Responses to Thermal Hyperalgesia and Mechanical Allodynia in a Rat Model of Acute Postoperative Pain (2003)

The more rapid recovery of the younger animals from the mechanical allodynia but not thermal hypersensitivity after surgery suggests the presence of developmental differences in modulation of A-fiber sensitization after surgery. However, the lack of age difference in recovery of thermal hypersensitivity after surgery suggests that sensitization of C-fiber input has a similar time course of resolution of pain over the ages studied in this model. The neural bases for these developmental differences are under study and may lead to a better understanding of pain during development and altered approaches to treatment of postoperative pain in neonates and infants.
Triggered Assembly of a DNA-Based Membrane Channel (2022)

Chemistry is in a powerful position to synthetically replicate biomolecular structures. Adding functional complexity is key to increase the biomimetics' value for science and technology yet is difficult to achieve with poorly controlled building materials. Here, we use defined DNA blocks to rationally design a triggerable synthetic nanopore that integrates multiple functions of biological membrane proteins. Soluble triggers bind via molecular recognition to the nanopore components changing their structure and membrane position, which controls the assembly into a defined channel for efficient transmembrane cargo transport. Using ensemble, single-molecule, and simulation analysis, our activatable pore provides insight into the kinetics and structural dynamics of DNA assembly at the membrane interface. The triggered channel advances functional DNA nanotechnology and synthetic biology and will guide the design of controlled nanodevices for sensing, cell biological research, and drug delivery.
Millimeter Wave: The Future of Commercial Wireless Systems (2016)

Millimeter wave (mmWave) is coming to fifth generation (5G) cellular, wireless local area networks (WLANs), and wireless personal area networks (WPANs). The benefits of using millimeter wave carriers arise from the potential for larger bandwidths (hundreds of megahertz to gigahertz) compared to lower carrier frequencies. Differences in the propagation, challenges introduced by hardware constraints, and computational issues related to the high data rates have reinvigorated research in wireless communications. This paper, which accompanies a keynote talk with the same name, provides a roadmap to the author's research results in the evolving area of mmWave for consumers.
Application of a modified elastic spectator model to proton transfer reactions in polyatomic systems (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of a modified elastic spectator model to proton transfer reactions in polyatomic systemsM. L. Vestal, A. L. Wahrhaftig, and J. H. FutrellCite this: J. Phys. Chem. 1976, 80, 26, 2892–2899Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/j100567a015https://doi.org/10.1021/j100567a015research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Biomimetic Synthesis of SNF4435C (I) and SNF4435D (II), and the Total Synthesis of the Polyene Metabolites Aureothin (IIIa), N‐Acetyl‐aureothamine (IIIb) and Spectinabilin (IV). (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) Antibody in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers (2014)

The MMp40 (BC28) monoclonal antibody is a high-quality screening antibody for determining squamous cell carcinoma in lung cancers, skin cancers of squamous or basal cell origin, squamous cell head and neck cancers, and urothelial carcinomas.
TCP/IP: The next generation (1995)

After tracing the evolution of Transmission Control Protocol/Internet Protocol (TCP/IP) from its academic and government research heritage to its current commercial use, we survey new directions in TCP/IP. We explore the issues that derive from growth in scale and function, which are prompting the Internet community to assess significant changes in the protocol suite. We relate these issues to the IBM Open Blueprint™. Much as the IBM Personal Computer brought computing to millions of people, the Internet service of the IBM Global Network and IBM's Internet Connection products are bringing networking to millions of people and are changing how customers are transacting business among themselves and with IBM.
Performance Testing of a Vehicular Flywheel Energy System (2005)

The University of Texas at Austin Center for Electromechanics has designed and integrated a 40,000 rpm, 150 kW, 1.93 kWh flywheel energy storage system into a hybrid electric transit bus as a demonstration of the technology. The flywheel stores energy recovered during braking and returns it to the power train during acceleration, reducing the peak power requirements and size for the prime power unit. Additionally, the system provides a longer life energy storage alternative to the more traditional chemical battery bank. While the flywheel system was demonstrated on a transit bus, similar improvements are possible on other terrestrial or marine mobile applications. This paper presents the results and information learned during several multi-thousand-cycle duration tests, composite flywheel tests, terrain-simulating shaker tests, and on-bus road tests.
Wide continuous wavelength tuning of a narrow linewidth DBR laser (1992)

A continuous wavelength tuning range of 5.4 nm is obtained for a three-section DBR (distributed Bragg reflector) laser by applying one control current in both forward and reverse bias directions. In the reverse direction no significant linewidth broadening is seen due to the absence of injection-recombination shot noise, and a linewidth of less than 3 MHz is obtained over a wavelength span of 1.8 nm. The minimum linewidth observed is 580 kHZ.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The mRNA expression of amino acid and sugar transporters, aminopeptidase, as well as the di- and tri-peptide transporter PepT1 in the intestines of Eimeria infected broiler chickens (2016)

Coccidiosis in chickens is caused by infection of gut epithelial cells with protozoan parasites of the genus Eimeria This disease causes losses to the poultry industry since infected birds fail to gain weight as rapidly as non-infected birds and efficiency of feed conversion is compromised. For the present study the effect of Eimeria on expression of components of amino acid and sugar uptake mechanisms was determined. Broiler chicks were infected with Eimeria maxima, which infects the jejunum; Eimeria acervulina, which infects the duodenum; or Eimeria tenella, which infects the ceca. Sections of the jejunum, duodenum, and ceca (depending on species of Eimeria) were taken at several time points between d zero and 14 post infection (PI) for mRNA expression analysis. Genes examined included one digestive enzyme, 7 peptide and amino acid transporters located on the brush border, 8 transporters located at the basolateral surface of the gut epithelium, and 5 sugar transporters. All 3 Eimeria species examined caused decrease in expression of brush border transporters particularly at d 5 to 7 PI, which corresponds to the time when pathology is greatest. The same pattern was seen in expression of sugar transporters. However, the expression of basolateral transporters differed among species. Eimeria tenella infection resulted in decreased expression of all basolateral transporters, while E. maxima infection caused increased expression of 2 genes and slight decrease in expression of the remaining 5 genes. Infection with E. acervulina resulted in increased expression at the height of infection of all but one basolateral transporter. In conclusion, Eimeria infection causes a general decrease in gene expression of sugar transporter and brush border AATs at the height of infection. However the expression of basolateral transporters is increased in E. maxima and E. acervulina infected birds. It is possible that decreased expression of brush border transporters in combination with increased expression of basolateral transporters leads to decrease of nutrients available for the parasite, thus limiting parasite reproduction.
A WSN Based Framework for Human Health Monitoring (2011)

Wireless Sensor Networks (WSN) is neoteric progressing technology which addresses solutions to critical application environments. It allows the assimilation of medical sensors to form a group scenario which makes it feasible to remotely collect and communicate the physiological signals of a patient, thus preventing the patient from being tied to a particular set of monitoring medical instruments and thereby facilitate the patient's prior acquittal from the hospital. The sensor nodes adhered to the human body form a network and transmit the collected data to the medical server at a remote location via internet thus forming a Wireless Body Area Network (WBAN). We propose a framework for WBAN which discusses the working of the WBAN in three phases and the parameters which influence the working of each phase. Further the work also concentrates to generate a full fledged monitoring system for patient monitoring in health care.
Shape from Thermal Radiation: Passive Ranging Using Multi-spectral LWIR Measurements (2022)

In this paper, we propose a new cue of depth sensing using thermal radiation. Our method realizes passive, texture independent, far range, and dark scene applicability, which can broaden the depth sensing subjects. A key ob-servation is that thermal radiation is attenuated by the air and is wavelength dependent. By modeling the wavelength-dependent attenuation by the air and building a multi-spectral LWIR measurement system, we can jointly estimate the depth, temperature, and emissivity of the target. We analytically show the capability of the thermal radiation cue and show the effectiveness of the method in real-world scenes using an imaging system with a few bandpass filters.
After two tracks: Integrating START and INF (1984)

Abstract Growing interest in comprehensive arms control has engendered increasing momentum for the proposal to integrate the START and INF negotiations. The author examines the premise that comprehensive arms control talks would be more effective, and considers whether the obstacles to integration currently blocking progress can be more easily solved in an integrated framework.
Information Overload: How the Wisconsin Supreme Court Expanded the Doctrine of Informed Consent, 46 J. Marshall L. Rev. 1097 (2013) (2013)

CaseOn the night of June 13, 2003, Thomas Jandre was drinking coffee at work when he suddenly began experiencing strange and uncomfortable symptoms. 1His coffee sprayed out of his nose, his speech was slurred, he felt dizzy, his face drooped, and he had trouble maintaining balance. 2 His co-workers rushed him to the hospital. 3 At the emergency room, Dr. Therese Bullis believed Jandre was suffering from either Bell's palsy or a transient ischemic attack (known as TIA or "mini-stroke"). 4 Bullis conducted various diagnostic tests including a CT scan and listening for bruits, a technique to detect an ischemic stroke event. 5 As a result of these tests, Bullis believed a stroke was a remote possibility, 6 so she chose not to order additional testing. 7 Because the preliminary test
High-Throughput Genetic Mapping of Mutants via Quantitative Single Nucleotide Polymorphism Typing (2009)

Advances in next-generation sequencing technology have facilitated the discovery of single nucleotide polymorphisms (SNPs). Sequenom-based SNP-typing assays were developed for 1359 maize SNPs identified via comparative next-generation transcriptomic sequencing. Approximately 75% of these SNPs were successfully converted into genetic markers that can be scored reliably and used to generate a SNP-based genetic map by genotyping recombinant inbred lines from the intermated B73 x Mo17 population. The quantitative nature of Sequenom-based SNP assays led to the development of a time- and cost-efficient strategy to genetically map mutants via quantitative bulked segregant analysis. This strategy was used to rapidly map the loci associated with several dozen recessive mutants. Because a mutant can be mapped using as few as eight multiplexed sets of SNP assays on a bulk of as few as 20 mutant F(2) individuals, this strategy is expected to be widely adopted for mapping in many species.
Unveiling the Challenges in Tandem Ureteral Stent Management for Malignant Ureteral Obstruction: Failure Rate, Risk Factors, and Durability of Their Replacement (2023)

TUS insertion for the treatment of MUO is feasible and has good outcomes with a relatively low failure rate. Primary pelvic mass and distal ureteral obstruction pose higher risks for TUS failure. Replacing failed TUSs with a new pair has a success rate of 42.8%. Consideration should be given to placing larger diameter stents when replacing failed TUS.
Photoluminescence properties and high resolution x-ray diffraction investigation of BInGaAs/GaAs grown by the metalorganic vapour phase epitaxy method (2012)

In this paper, we report the obtention of quaternary (B)InGaAs/GaAs alloys grown by metal organic vapour phase epitaxy has been studied using high resolution x ray diffraction (HRXRD) and photoluminescence (PL) measurements. HRXRD has been achieved to determine the indium fraction (35%) incorporated into BGaAs, which shows that the strain effects have been reduced compared to the InGaAs one. Through further careful inspection, boron-indium gallium arsenic (BInGaAs) epilayer exhibits several PL peak emissions. They are associated to the exciton bond induced by the boron isoelectronic and cluster defect states. In contrast, for the BInGaAs single quantum well (SQW), we have a band to band transition mainly influenced by the confinement of electron-hole pairs in the BInGaAs well. However, the PL of BInGaAs SQW temperature-dependence has shown a localization effect due to the conduction-band modulation induced by the boron clustering in the structure. At high PL temperature, we have a band to band transition of electron-hole pairs in the BInGaAs well.
HDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components (2015)

The current study suggests a clinical role for HDACi in human epithelioid sarcoma, which, when combined with EZH2 inhibitors, could serve as a novel therapeutic strategy for epithelioid sarcoma patients. Future investigations targeting specific HDAC isoforms along with EZH2 may potentially maximizing treatment efficacy.
Chirality and Biological Activity (2003)

Abstract Throughout the past two decades, the relationship between chirality and biological activity has become an area of vital importance to medicinal chemists in both the design and synthesis of novel small molecules. In this chapter, the definition of chirality and its biological implications are covered. The synthetic, chromatographic, and crystallization approaches to single isomer compounds are discussed with reference to the differing biological activities exhibited by stereoisomers.
Data from Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma (2023)

&lt;div&gt;Abstract&lt;p&gt;The symbiotic interactions between cancer stem cells and the tumor microenvironment (TME) are critical for tumor progression. However, the molecular mechanism underlying this symbiosis in glioblastoma (GBM) remains enigmatic. Here, we show that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 (BMAL1) in glioma stem cells (GSC) drive immunosuppression in GBM. Integrated analyses of the data from transcriptome profiling, single-cell RNA sequencing, and TCGA datasets, coupled with functional studies, identified legumain (LGMN) as a direct transcriptional target of the CLOCK–BMAL1 complex in GSCs. Moreover, CLOCK-directed olfactomedin-like 3 (OLFML3) upregulates LGMN in GSCs via hypoxia-inducible factor 1-alpha (HIF1α) signaling. Consequently, LGMN promotes microglial infiltration into the GBM TME via upregulating CD162 and polarizes infiltrating microglia toward an immune-suppressive phenotype. In GBM mouse models, inhibition of the CLOCK–OLFML3–HIF1α–LGMN–CD162 axis reduces intratumoral immune-suppressive microglia, increases CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration, activation, and cytotoxicity, and synergizes with anti–programmed cell death protein 1 (anti–PD-1 therapy). In human GBM, the CLOCK-regulated LGMN signaling correlates positively with microglial abundance and poor prognosis. Together, these findings uncover the CLOCK–OLFML3–HIF1α–LGMN axis as a molecular switch that controls microglial biology and immunosuppression, thus revealing potential new therapeutic targets for patients with GBM.&lt;/p&gt;&lt;/div&gt;
Music and Violence in History (2017)

The connection between music and violence is a powerful and transcultural source of mythic and historical narratives. It is the potentially destructive power of music that underpins Homer's account of Ulysses and the sirens whose song drew sailors to their death, and whose connection with danger would be commemorated in the name given to a sound alarm invented in the nineteenth century. Plato and Cassiodorus believed that certain modes could induce mental disturbances, and the early Christian church believed that pagan residues in music could be exploited by the Devil to produce depravity, and that witches used music to carry out their evil work. In the sixteenth century reports of hostility were found to the intrusiveness of travelling minstrelsy in the streets of one of Europe's most rapidly developing cities, London, and in particular, complaints about repetitiveness: 'the too speedy return of one manner of tune, doth too much annoy'.
Elemental bio-imaging of melanoma in lymph node biopsies (2008)

The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging of (31)P within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative (31)P concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the (31)P/(34)S ratio. (31)P/(66)Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.