gebhart/patrepeval huggingface dataset:
Micro-Angiographic Fluoroscope: Comparison for Different Input Phosphors (2014)

Although flat panel detectors are preferred for image-guided interventional endo-vascular treatments of stroke, they still have limitations in spatial resolution and excess additive noise, which restricts their low-dose performance. The Micro-Angiographic Fluoroscope (MAF), a CCD-based region-of-interest indirect X-ray imager recently developed, can meet the needs for high-resolution, high-sensitivity, real-time image guidance. Although the prototype MAF has better resolution (MTF) and detective quantum efficiency (DQE) than a standard flat panel detector, its performance could be improved by a change in the phosphor. The spatial resolution of such X-ray-to-light converting phosphors is limited by stochastic blurring and k-fluorescent X-ray reabsorption. Thinner phosphors generally improve resolution at the cost of lowering quantum detection efficiency (QDE) and increasing Swank noise, while thicker phosphors provide better absorption at the expense of spatial resolution. Two other Hamamatsu CsI(Tl) phosphors, 300- μm-thick HR, and 500- μm-thick HR, both without front reflective surface, were compared with the current 300- μm HL phosphor with front reflective surface. The phosphors were evaluated by comparing the MTF, NNPS, and DQE of the MAF detector used with each phosphor. All detector configurations showed linearity and quantum noise limited operation for a large range of exposures appropriate for both fluoroscopy and angiography. While the 300- μm HR type prototype demonstrated better resolution than the 500- μm HR type, the latter demonstrated better overall DQE and improved resolution compared to the original 300- μm HL, suggesting it would be the better choice for the MAF design.
The Role of Neuroimmunomodulation in Alzheimer's Disease (2009)

The idea that alterations in the brain immunomodulation are critical for Alzheimer's disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines have revealed the involvement of inflammatory processes in AD. We have proposed the damage signal hypothesis as a unifying scheme in that release of endogenous damage/alarm signals, in response to accumulated cell distress (dyslipidemia, vascular insults, head injury, oxidative stress, iron overload, folate deficiency), is the earliest triggering event in AD, leading to activation of innate immunity and the inflammatory cascade. Inflammatory cytokines play a dual role, either promoting neurodegeneration or neuroprotection. This equilibrium is shifted toward the neurodegenerative phenotype upon the action of several risk factors that trigger innate damage signals that activate microglia and the release of tumor necrosis factor-alpha, interleukin-6, and some trophic factors. In this neuroimmunomodulatory hypothesis we integrate different risk factors with microaglial activation and the resulting neuronal alterations and hyperphosphorylations of tau protein. The progression of AD, with slowly increasing damage in brain parenchyma preceding the onset of symptoms, suggests that tissue distress triggering damage signals drives neuroinflammation. These signals via toll-like receptors, receptors for highly glycosylated end products, or other glial receptors activate sensors of the native immune system, inducing the anomalous release of cytokines and promoting the neurodegenerative cascade, a hallmark of brain damage that correlates with cognitive decline.
(Digital Presentation) Fundamentals of Deep Eutectic Solvents As Electrolytes for Lithium-Ion Batteries (2022)

Deep eutectic solvents (DESs) have emerged as an alternative to both common organic solvents and ionic liquids (ILs). DESs share physicochemical properties with ILs such as low vapor pressure, high thermal stability, high viscosity while offering advantages such as low toxicity, lower cost, and ease of preparation. Moreover, DESs are attractive candidates for electrochemical applications due to their large voltage windows and solubility properties. DESs as a solvent class share a general composition of a hydrogen bond donor (HBD), typically a polyol, amide, or acid, and a hydrogen box acceptor (HBA), usually a quaternary ammonium or phosphonium salt. At a specific molar composition of a HBD and HBD, the DES forms a eutectic mixture resulting in a large melting point depression due to extensive hydrogen bonding between the components. Despite being widely studied, the microscopic structures of DESs have remained largely uncharacterized. Herein, we present a multitechnique NMR study of two DESs: glyceline (glycerol + choline chloride) and ethaline (ethylene glycol + choline chloride). Fast-field cycling 1 H relaxometry, pulsed field gradient diffusion, nuclear Overhauser effect spectroscopy (NOESY), 13 C NMR relaxation, and pressure-dependent NMR experiments are deployed to sample a range of frequencies and modes of motion of the polyol and choline components of the DES. Generally, translational and rotational diffusion of polyols are more rapid than those of choline while short-range rotational motions observed from 13 C relaxation indicate slow local motion of glycerol at low choline chloride (ChCl) content. We show how the additional hydroxyl group present in glycerol contributes to not only higher viscosities, but a larger perturbation of the hydrogen bonding network by the addition of ChCl. Additionally, we have investigated the solubility properties of several lithium salts (LiTFSI, LiFSI, LiPF 6 , LiBF 4 , and LiOAc) in these DESs and utilized the same suite of NMR techniques to understand how they act as solvents. We observe that due to anion effects, the heterogeneities present in DES result in differential solvation for some species where there is a distinction of lithium salts co-existing in these holes as well as the bulk. The large changes in the structural organization of DESs that result from the presence of lithium salts will serve as a guide to the design of a new class of electrolytes for lithium-ion batteries.
An Unprecedented Rhodium‐Catalyzed Asymmetric Intermolecular Hydroacylation Reaction with Salicylaldehydes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design-Build Agreements: A Case Study Review of the Included Handover Requirements (2009)

Road infrastructure is a key component of any region’s transportation system. It allows unprecedented levels of mobility, accessibility, and economic growth. On the other hand, the cost associated with inadequate road infrastructure can amount to billions of dollars. In the U.S., the largest revenue source for the funding of transportation infrastructure is the federal and state fuel taxes. These taxes were conceived in the 1950s as an indirect charge to recover the costs of vehicle travel on the U.S. highway system. However, this tax has not increased with the inflation rate and given increasing maintenance and construction costs, and more fuel efficient vehicles, the vehicle per mile tax has become inadequate. State budget shortfalls affect the ability to maintain existing facilities properly and may lead to delayed maintenance which in turn may reduce the lifespan of roads, bridges, ports, and other infrastructures.
French law: what about a reasoned reimbursement of serum vitamin D assays? (2016)

The number of serum 25-hydroxyvitamin D (25OHD) assays has increased tenfold in France in less than 10 years, sometimes for invalidated reasons. In 2013, the French National Authority for Health (Haute autorité de santé, or HAS) limited the indications for serum 25OHD measurements to rickets/osteomalacia, older adults with recurrent falls, monitoring of kidney transplant in adults, and surgical treatment of obesity in adults. Our aim here was to note that other indications for serum 25OHD measurements are supported by previous literature and by a number of national and international recommendations, in particular the following: any situation of bone fragility, any chronic renal failure <45 mL/min/1.73m<sup>2</sup>, any situation of malabsorption, clinical signs consistent with vitamin D deficiency or vitamin D overload, and calcium phosphorus evaluation. We suggest that the measurement of serum 25OHD concentration should remain reimbursed as part of these extended indications.
ChemInform Abstract: THE KATADA REACTION: A STUDY OF EXPERIMENTAL CONDITIONS (1985)

Abstract Am Beispiel des 2‐Picolin‐N‐oxids (I) wird die Katada‐Reaktion zu (II) untersucht.
Chemical Reagents for the Development of Latent Fingerprints. III: Visualization of Latent Fingerprints by Fluorescent Reagents in Vapor Phase (1980)

The use of certain fluorescing vapor-phase chemicals for the development of latent fingerprints is described. Some advantages of these chemicals over other methods that use fluorescers are discussed.
Supplementary Figure 3 from Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer (2023)

&lt;p&gt;PDF file - 39K, Pathologic score of PanIN lesions in Pdx1-Cre; LSL-KRAS G12D mice, wild type (n=4 mice) or heterozygous (n=7) for the phospho-rpS6 mutant.&lt;/p&gt;
Dental Pulp Stem Cells (DPSCs), differentiating into osteoblasts, become a source of the pro-apoptotic factor TRAIL: evaluation of an experimental model for cancer therapy (2010)

The DPSCs belong to the family of mesenchymal stem cells (MSCs) and are capable, if properly stimulated to differentiate into different cell types including osteoblasts. It has been shown, in animal models, that MSCs derived from bone marrow, producing TNF-related apoptosis-inducing ligand (TRAIL), inhibit the growth of tumors that metastatize to the bone tissue, including lung cancer; however, the expression of TRAIL by the MSCs to be effective, must be stimulated with genetic engineering techniques with the involvement of bacterial vectors. TRAIL is a pro-apoptotic factor, member of the super-family of tumor necrosis factors, known for its peculiarity to selectively induce apoptosis in cancer cells. TRAIL can activate apoptotic signals by binding two different death receptors, DR4 and DR5. In our work we evaluated the production of TRAIL by DPSCs differentiated toward the osteoblastic phenotype. Microarray experiments, also supported by real-time PCR, showed that in DPSCs after differentiation, the expression of TRAIL increased fifteen times. Moreover, cell viability tests have shown that DPSCs differentiating into osteoblasts become resistant to the pro-apoptotic effect of the molecule. This strong resistance derives from a significant decrease in the expression of TRAIL receptors DR4 and DR5, and is confirmed by the weak activation of intracellular apoptotic signal (caspase 3) following the exposure to the molecule. Conversely, the tumor cell lines expressed high levels of DR4 and DR5, and in the presence of TRAIL, activate the intracellular apoptotic signals (caspase 3-8). Thus, the DPSCs, differentiated into osteoblasts, expressing high levels of TRAIL and developing a resistance to the apoptotic effect of the molecule, could represent a valuable therapeutic approach to cancer therapy.
General and Theoretical Aspects (2004)

This chapter contains sections titled: Introduction Theoretical Methodology Ab Initio Calculations Relativistic Effects Periodic Trends Structures and Bond Energies Singlet–Triplet Energy Differences Inversion Barriers Multiply Bonded Compounds Hypervalent Compounds Acknowledgments References
Database engines on multicores, why parallelize when you can distribute? (2011)

Multicore computers pose a substantial challenge to infrastructure software such as operating systems or databases. Such software typically evolves slower than the underlying hardware, and with multicore it faces structural limitations that can be solved only with radical architectural changes. In this paper we argue that, as has been suggested for operating systems, databases could treat multicore architectures as a distributed system rather than trying to hide the parallel nature of the hardware. We first analyze the limitations of database engines when running on multicores using MySQL and PostgreSQL as examples. We then show how to deploy several replicated engines within a single multicore machine to achieve better scalability and stability than a single database engine operating on all cores. The resulting system offers a low overhead alternative to having to redesign the database engine while providing significant performance gains for an important class of workloads.
Airborne radar antenna modules using lightweight temperature-resistant materials (2002)

In contemporary radar technology, increasingly complex antennas must maintain a low weight requirement and provide sufficient robustness to a harsh environment. Among many desired features, a high degree of antenna integration and the ability to incorporate the design into an aeroplane's fuselage or wings are of the highest priority. In order to meet such demands, advanced power dividing and phasing networks together with digital signal processors should be located close to the transmitting and receiving antennas preferably in multilayer architectures. Such architectures put stringent requirements on the electrical and mechanical properties of dielectric substrates. This paper presents some results concerning the design and development of multilayer antenna elements and the associated signal dividing and phasing networks using honeycomb and quartz-fibre composite materials, which are widely used in the aerospace industry.
Effect of Filler on the Aging Potential of Asphalt Mixtures (2005)

In this work, the effect that filler has on the aging of bitumen was analyzed but with the filler being incorporated by volume, not by weight. The Universal de Caracterización de Ligantes method was used as the process of accelerated aging, and a new direct tensile test was used to determine the toughness of the aged mixture and, thus, to assess the effect the filler has. All tests performed for this paper have shown the protective effect of the fillers used. The new direct tensile test developed by the Road Research Laboratory of the Technical University of Catalonia allows observation of how an increase in filler produces an increase in the breaking load and a decrease in the maximum deformation: the hydrated lime tends to stiffen the mixture less and make it less brittle than does calcium carbonate. To minimize the effect of aging on bitumen, the filler content proposed must be 20% or 30% less than the content recommended in conditions where there is no aging, so that when the mixture ages, the mastic is able to build up the maximum energy possible.
Hybrid, finite element-artificial neural network model for composite materials (2004)

An application of Artificial Neural Networks for a definition of the effective constitutive law for a composite is described in the paper. First, a classical homogenisation procedure is directly interpreted with a use of this numerical tool. Next, a self-learning Finite Element code (FE with ANN inside) is used in the case when the effective constitutive law is deduced from a numerical experiment (substituting here a purely phenomenological approach). The new contribution to the classical self-learning procedure consists of its adaptation to a case of a non-monotonic loading (non-to-one load-deformation curve). This new ability of the method is principally due to the incremental form of the constitutive equation and the respective scheme of the neural network structure. Also an organisation of a constitutive data-base containing learning patterns is suitably modified. It is shown by examples that the training process is very quick. The error of this method is smaller, comparing to other schemes of data acquisition.
Dietary lipid sources and levels for weanling pigs (2013)

Collaborative studies comprising growth performance and metabolism experiments were conducted to reevaluate growth performance and nutrient and energy utilization responses of nursery pigs to dietary lipid sources and levels. Two lipid sources (soybean oil or tallow) were included at the rate of 1%, 3%, or 5% at the expense of cornstarch in a 2 × 3 factorial arrangement for 6 diets, and Lys was added to maintain a constant calorie:Lys ratio. A growth performance experiment (d 0 to 7, d 7 to 21, and d 21 to 35 postweaning) involving a total of 822 crossbred pigs was conducted at 9 research stations. Each station contributed 2 to 7 replicate pens with 4 to 6 pigs per pen, resulting in a total of 28 replicate pens per diet. The initial BW ranged from 5.9 to 7.3 kg, and the final BW ranged from 20.9 to 28.9 kg. Diets fed during d 7 to 21 and d 21 to 35 were evaluated with 120 barrows in 2 metabolism experiments with 10 individually fed barrows per diet to determine digestibility and retention of nutrients and energy. Lipid source and the interaction between lipid level and source did not affect growth performance. Lipid did not affect growth performance from d 0 to 7. There was a quadratic decrease (P < 0.05) in ADG with increasing level of added lipid only during d 7 to 21 postweaning. The ADFI was decreased (P < 0.01) both during d 7 to 21 and d 21 to 35 postweaning with increasing level of lipid supplementation. A linear improvement (P < 0.001) in G:F with increasing level of lipid supplementation occurred during both d 21 to 35 and d 0 to 35 postweaning. There was a linear increase in DE, ME, and nitrogen-corrected ME (MEn) of diets fed during d 7 to 21 postweaning with increasing lipid level regardless of lipid source. For diets fed during d 21 to 35 postweaning, there were interactions (P < 0.05) between lipid source and level for digestibility of DM, N, lipid, and energy and for DE, ME, and MEn of diets. The improved feed efficiency was, perhaps, partly attributable to the increase in ME content of the diets with added lipids. There were interactions (P < 0.05) between lipid source and level for efficiency of energy use for BW gain for diets fed during d 21 to 35. The efficiencies of use of DE, ME, and NE for BW gain were not affected in pigs fed diets containing increasing levels of soybean oil; however, there were linear increases in these response criteria for pigs fed diets containing increasing levels of tallow. These results indicate that the energy values of soybean oil from the 2012 NRC study used in formulating these diets were fairly accurate.
Multi-optima exploration with adaptive Gaussian mixture model (2012)

In learning by exploration problems such as reinforcement learning (RL), direct policy search, stochastic optimization or evolutionary computation, the goal of an agent is to maximize some form of reward function (or minimize a cost function). Often, these algorithms are designed to find a single policy solution. We address the problem of representing the space of control policy solutions by considering exploration as a density estimation problem. Such representation provides additional information such as shape and curvature of local peaks that can be exploited to analyze the discovered solutions and guide the exploration. We show that the search process can easily be generalized to multi-peaked distributions by employing a Gaussian mixture model (GMM) with an adaptive number of components. The GMM has a dual role: representing the space of possible control policies, and guiding the exploration of new policies. A variation of expectation-maximization (EM) applied to reward-weighted policy parameters is presented to model the space of possible solutions, as if this space was a probability distribution. The approach is tested in a dart game experiment formulated as a black-box optimization problem, where the agent's throwing capability increases while it chases for the best strategy to play the game. This experiment is used to study how the proposed approach can exploit new promising solution alternatives in the search process, when the optimality criterion slowly drifts over time. The results show that the proposed multi-optima search approach can anticipate such changes by exploiting promising candidates to smoothly adapt to the change of global optimum.
Substructure Hybrid Simulation with Multiple-Support Excitation (2011)

Substructure hybrid simulation of engineering structures subjected to multiple-support excitation (MSE) is investigated. In time-history analysis of MSE problems, the equations of motion are generally posed in relative coordinates (designated EOM-rel), which only require the ground acceleration as an input. However, the suitability of EOM-rel for hybrid simulation with MSE is unclear. Because estimating the tangent stiffness of the experimental substructure during testing is challenging, constant stiffness is often adopted in widely used integration schemes for hybrid simulation (e.g., the operator-splitting method); the equivalent force is not updated during experimentation. In previous studies, the equations of motion in absolute coordinates (designated EOM-abs) have been employed for hybrid simulation considering MSE. With EOM-abs, nonlinearity in the stiffness matrix is naturally considered in the measured restoring force—no approximation is involved. One drawback to EOM-abs is that the displacement and velocity of the ground motion must be computed prior to the experiment. This paper carefully formulates the hybrid simulation problem for structures subjected to MSE and examines the tradeoffs in the two approaches. First, the EOM-rel approximation and the EOM-abs are formulated and compared for a nonlinear single degree of freedom structure with nonlinearities modeled by a Bouc-Wen model subjected to two ground inputs. Significant error is found in the EOM-rel approximation because of the constant stiffness matrices used. Both formulations are then evaluated in hybrid simulation of a four-span highway ramp bridge. This study demonstrates that the EOM-rel approximation can provide results with good accuracy if the nonlinear components of the experimental substructure do not significantly affect the global stiffness matrix. Otherwise, the EOM-abs is recommended for hybrid simulation with MSE.
Clinical and Microbiologic Effects of Subgingival Controlled‐Release Delivery of Chlorhexidine Chip in the Treatment of Periodontitis: A Multicenter Study (2008)

The adjunctive use of the CHX chip resulted in a significant PD reduction and a clinical attachment gain compared to SRP alone. These results were concomitant with a significant benefit of SRP + CHX treatment on the subgingival microbiota.
The Use of Blast Furnace Slag for Removal of Phosphorus from Wastewater in Sweden—A Review (2010)

Research on Phosphorus (P) removal capacity by blast furnace slags (BFS) has been undertaken in Sweden for the last decade. Both laboratory experiments and field trials have been carried out. While laboratory investigations revealed that BFS has a high P-sorption capacity (95–100%), P removal in field trials was much lower, ranging from 40 to 53%. In addition, a number of problems have been observed in BFS field testing including clogging, sulfuric odor and environmental (regulatory) concerns about possible leaching of heavy metals from the slag. In spite of these problems, and questioning by the environmental regulatory authorities, research continues to provide evidence that BFS can be regarded as a suitable filter media, and attempts have also been undertaken in order to further improve the P-removal capacity of this adsorbing material.
Effect of Lactoferrin and Iron on the Growth of Human Pathogenic Candida Species (2008)

Effect of lactoferrin and iron have been studied on the multiplication and pseudohyphae production by three pathogenic Candida species viz., C. albicans, C. krusei and C. tropicalis. Results showed that lactoferrin showed significant antifungal effect on the three species tested, while the addition of iron enhance the multiplication of Candida species.