gebhart/patrepeval huggingface dataset:
Activity of Non-basal slips in Polycrystalline hcp Metals (2018)

There are many types of slip modes and twins in hcp metals. Knowledge of their activities during plastic deformation is very important to improve their mechanical properties efficiently. According to von-Mises criterion, five kinds of independent slip systems are required for uniform deformation of polycrystalline material. Basal slip system is the main slip mode of hcp metals such as magnesium, but the independent slip number is one two. Therefore, activation of non-basal slip systems is important for hcp metals to show good ductility. In this study, to investigate activity of non-basal slips in polycrystalline hcp metals, pure magnesium and Mg – (0.5 - 1.2) at.%Y alloy rolled sheet were stretched at room temperature. Activated slip systems in each grains were evaluated from orientations of slips lines. In pure magnesium and Mg – Y alloys, slip lines of second order pyramidal (c+a) slip (SPCS), first order pyramidal (c+a) slip (FPCS) and prismatic slip (PS) were observed even at yielding in addition to basal slip lines. Activities of FPCS and prismatic slips were increased with increasing strain in Mg - Y alloy polycrystals. Our study suggested that active non-basal slip system is (c+a) pyramidal slip and enhanced ductility of magnesium - yttrium alloy would be caused from increased activity of FPCS by yttrium addition.
10-Year History of Pitted Nails. (2015)

A man presented with a 10-year history of itchy, scaly, brittle fingernails that were pitted but not painful. His toenails were unaffected. He also had patches of dry, scaly skin on his scalp, low back, and genitals.
INCREASING THE EFFECTIVENESS OF AFFORESTATION PROJECTS IN THE TROPICS INVOLVING NONGOVERNMENTAL ORGANIZATIONS (1984)

SUMMARY Non-Governmental Organizations (NGOs) play a significant role in the funding and implementation of social forestry projects in developing nations, although it is difficult to quantify the scale of afforestation, the number of NGOs involved, and the funds which they commit to such projects. A preliminary list is given of international NGOs and NGOs based in the OECD nations which are involved in or supportive of forestry or forestry-related activities. It is recommended that far more publicity should be given to the need for afforestation in order to encourage NGOs to expand their activities in this field. There should be greater coordination between NGOs, governments and inter-governmental organizations, and closer links between NGOs themselves. Steps should also be taken to strengthen the technical capabilities of NGOs in forestry.
Recurrent acute biliary pancreatitis: the protective role of cholecystectomy and endoscopic sphincterotomy (2009)

From the literature data it can be concluded that ES is as effective in reducing RABP as cholecystectomy but inferior in reducing mortality and overall morbidity. The combination of ES and cholecystectomy seems superior to either of the treatment methods alone. A prospective randomized clinical trial comparing ES plus cholecystectomy with cholecystectomy alone is needed.
Engineering of Antimicrobial Surfaces by Using Temporin Analogs to Tune the Biocidal/antiadhesive Effect (2019)

Proliferation of resistant bacteria on biomaterials is a major problem leading to nosocomial infections. Due to their broad-spectrum activity and their ability to disrupt bacterial membranes through a rapid membranolytic mechanism, antimicrobial peptides (AMPs) are less susceptible to the development of bacterial resistance and therefore represent good candidates for surface coating strategies to prevent biofilm formation. In this study, we report on the covalent immobilization of temporin-SHa, a small hydrophobic and low cationic antimicrobial peptide exhibiting broad-spectrum activity, and (SHa) analogs on modified gold surfaces. Several analogs derived from SHa with either a carboxamidated ([K³]SHa, d-[K³]SHa) or a carboxylated C-terminus ([K³]SHa-COOH) were used to achieve peptide grafting on gold surfaces modified by a thiolated self-assembled monolayer (SAM). Surface functionalization was characterized by polarization modulation infrared reflection absorption spectroscopy (PM-RAIRS) and X-ray photoemission spectroscopy (XPS). The antibacterial properties of the temporin-functionalized surfaces were tested against the Gram-positive <i>Listeria ivanovii</i>. Direct visualization of the peptide effects on the bacterial membrane was investigated by scanning electron microscopy equipped with a field emission gun (SEM-FEG). All active temporin analogs were successfully grafted and display significant antibacterial activity (from 80 to 90% killing efficiency) in addition to a 2-fold decrease of bacterial adhesion when all d-SHa analogs were used.
Highly Sensitive Assay for Detection of Enterovirus in Clinical Specimens by Reverse Transcription-PCR with an Armored RNA Internal Control (2004)

The objective of the present study was the development of a diagnostic reverse transcription (RT)-PCR for the specific detection of enterovirus (EV) RNA in clinical specimens controlled by an internal control (IC) RNA. The IC RNA contains the same primer binding sites as EV RNA but has a different probe region. The IC RNA was packaged into an MS2 phage core particle (armored) and was added to the clinical sample to allow monitoring of both extraction efficiency and RT-PCR efficiency. Serial dilutions of the IC RNA were made, and the detection limit of the RT-PCR was tested in a background of EV RNA-negative cerebrospinal fluid. The sensitivity and specificity of the RT-PCR assay were tested by using all 64 known EV serotypes, several non-EV serotypes, and two Quality Control for Molecular Diagnostics (QCMD) Program EV proficiency panels from 2001 and 2002. In total, 322 clinical specimens were tested by RT-PCR, and to establish the clinical utility of the RT-PCR, a comparison of the results of viral culture and RT-PCR was done with 87 clinical specimens. The lower limit of sensitivity was reached at about 150 copies of IC RNA/ml. All 64 EV serotypes were positive, while all non-EV serotypes were negative. All culture-positive samples of the 2001 QCMD proficiency panel (according to the 50% tissue culture infective doses per milliliter) were positive by RT-PCR. Invalid results, i.e., negativity for both EV RNA and IC RNA, due to inhibition of RT-PCR were observed for 33.3% of the members of the 2002 QCMD proficiency panel and 3.1% of the clinical specimens. Inhibition of RT-PCR could be relieved by the addition of 400 ng of bovine alpha-casein per microl to both the RT reaction mixture and the PCR mixture. With this optimized protocol, the results for all samples of the 2002 QCMD proficiency panel and all clinical specimens except one fecal sample (0.3%) were valid. Evaluation of the clinical samples demonstrated that EV infection could be detected in 12 of 87 samples (13.8%) by RT-PCR, while viral culture was negative. Our data show that the RT-PCR with armored IC RNA offers a very reliable and rapid diagnostic tool for the detection of EV in clinical specimens and that the addition of bovine alpha-casein relieved inhibition of the RT-PCR for 99.7% of clinical specimens.
20614 Biological Signal Analysis of Human Body Subjected to Chaotic Excitation (2006)

Results of biological signal analysis of human body subjected to chaotic excitation are presented. Sinusoidal pressure and chaotic pressure are applied to the loins, in reclined position on the bed, respectively. The experiment is then repeated with blood stagnated human body. Electrical signals on the skin are then measured. An electrocardiogram (ECG) is detected from a chest of the body, while electromyogram (EMG) is detected from the muscles of both arms. Pulse sound diagram (PSD) is recorded by using a microphone. Based on time-series of ECG, EMG and PSD, the signals were then analyzed by power spectra and by calculation of their Maximum Lyapunov exponents. It is found that human muscles show influences whether by sinusoidal or chaotic pressure. It is also found that chaotic pressure gives the ECG lower Maximum Lyapunov exponent in both normal and blood-stagnated condition.
Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies. (1992)

It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded with either IL-1 (delivery rate 0.5, 2.0, or 4.0 micrograms/24 h, ip, for 1 week) or saline. At the end of the treatment the rats were decapitated, the adrenals were weighed, and the in vitro release of beta-endorphin (beta E) by the anterior pituitary and that of B by the adrenal gland were measured. Continuous administration of 2.0 and 4.0 micrograms IL-1/24 h resulted in a persistent increase in plasma ACTH and B concentrations compared to the levels in saline-infused rats, with peak levels on the first day of administration. In addition, adrenal weights of IL-1 rats were significantly higher than those of saline rats. The 4.0-micrograms IL-1/day in vivo treatment induced an increase in spontaneous in vitro secretion of beta E and B, while the in vitro responses of the pituitary (to CRF) and the adrenal (to ACTH) of animals treated in vivo with IL-1 were significantly diminished. IL-1 at a dose of 0.5 microgram failed to affect plasma ACTH and B values, adrenal weight, and in vitro beta E and B secretion. Chronic infusion of rats with 4.0 micrograms IL-1/day induced prolonged fever, whereas at lower doses of IL-1 (2.0 and 0.5 micrograms), temperatures were elevated only on the first 2 days of infusion. IL-1 at doses of 2.0 and 4.0 micrograms/day induced suppression of body weight gain on the first 2 days of the treatment period compared to saline treatment. Plasma norepinephrine and/or epinephrine concentrations were raised only on day 1 of the 2.0- and 4.0-micrograms IL-1 experiments. Thus, the observed effects of IL-1 on the hypothalamo-pituitary-adrenal axis probably do not result merely from stress induced by the treatment. Taken together, our data show the potential of IL-1 to induce a dose-dependent and long term activation of the pituitary-adrenal axis.
Biomechanical design using in-vitro finite element modeling of distal femur fracture plates made from semi-rigid materials versus traditional metals for post-operative toe-touch weight-bearing (2020)

This proof-of-concept study designs distal femur fracture plates from semi-rigid materials vs. traditional metals for toe-touch weight-bearing recommended to patients immediately after surgery. The two-fold goal was to (a) reduce stress shielding (SS) by increasing cortical bone stress thereby reducing the risk of bone absorption and plate loosening, and (b) reduce delayed healing (DH) via early callus formation by optimizing axial interfragmentary motion (AIM). Finite element analysis was used to design semi-rigid plates whose elastic moduli E ensured plates permitted AIM of 0.2 - 1 mm for early callus formation. A low hip joint force of 700 N (i.e. 100% x body weight) was applied, which corresponds to a typical 140 N toe-touch foot-to-ground force (i.e. 20% x body weight) recommended to patients after surgery. Analysis was done using 2 screw materials (steel or titanium) and types (locked or non-locked). Steel and titanium plates were also analyzed. Semi-rigid plates (vs. metal plates) had lower overall femur/plate construct stiffnesses of 508 - 1482 N/mm, higher cortical bone stresses under the plate by 2.02x - 3.27x thereby reducing SS, and lower E values of 414 - 2302 MPa to permit AIM of 0.2 - 1 mm thereby reducing DH.
A Pervasive Network Control Algorithm for Multicamera Networks (2014)

Owing to the increasingly large volume and complexity of captured videos, renewable energy systems based on solar energy are of particular interest in the design of energy harvesting (EH) wireless visual sensor networks (WVSNs). Since additional energy consumption following image capture occurs owing to image processing, mote operation, data transmission, and reception, the capture rate significantly affects the lifetime of a node. To this end, we explore a novel energy-efficient framework for EH-WVSN design by developing an optimal algorithm named capture rate and pervasive network control for multicamera networks where the quality of service is maximized by obtaining optimal values for the capture rate, allocated energy, and transmit power, based on field of view-based networking in the presence of event and power acquisition patterns. Through simulations, we demonstrate the feasibility of EH-WVSNs in terms of energy consumption, energy allocation, and capture rate in a realistic scenario (parking surveillance).
Targeted Immunomodulation of the NF-κB Pathway in Airway Epithelium Impacts Host Defense against Pseudomonas aeruginosa (2006)

We investigated the impact of inflammatory signaling in airway epithelial cells on host defense against Pseudomonas aeruginosa, a major cause of nosocomial pneumonia. In mice, airway instillation of P. aeruginosa resulted in NF-kappaB activation in the lungs that was primarily localized to the bronchial epithelium at 4 h, but was present in a variety of cell types by 24 h. We modulated NF-kappaB activity in airway epithelium by intratracheal delivery of adenoviral vectors expressing RelA (AdRelA) or a dominant inhibitor of NF-kappaB before P. aeruginosa infection. Bacterial clearance was enhanced by up-regulation of NF-kappaB activity following AdRelA administration and was impaired by treatment with a dominant inhibitor of NF-kappaB. The TNF-alpha concentration in lung lavage was increased by AdRelA treatment and beneficial effects of NF-kappaB up-regulation were abrogated in TNF-alpha-deficient mice. In contrast, NF-kappaB inhibition reduced MIP-2 expression and neutrophil influx following P. aeruginosa infection. Therefore, inflammatory signaling through the NF-kappaB pathway in airway epithelial cells critically regulates the innate immune response to P. aeruginosa.
Structure of the wall peptidoglycan of Streptomyces R39 and the specificity profile of its exocellular DD-carboxypeptidase-transpeptidase for peptide acceptors (1973)

peer reviewed
Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inﬂammation (2003)

The sesquiterpene lactone fraction of Saussurea lappa roots was evaluated for its effect on the transudative, exudative and proliferative phases of inflammation using the cotton pellet granuloma assay in rats. The fraction (25-100 mg/kg, p.o.) showed significant dose-dependent inhibition of the increase in wet weight of the cotton pellet at 3 h (transudative phase), leakage of dye from the bloodstream around granuloma at 24 h (exudative phase) and increase in dry weight of the cotton pellet on day 6 (proliferative phase). It significantly lowered the elevated biochemical parameters such as alkaline phosphatase, acid phosphatase, gamma-glutamyltranspeptidase and significantly elevated the lowered albumin concentration in serum. The studies suggest that the antiinflammatory activity of the sesquiterpene lactone fraction of S. lappa may, in part, be due to stabilization of lysosomal membranes and an antiproliferative effect.
Minimal Incision Technique Using a Two-Hole Plate for Fixation of Stable Intertrochanteric Hip Fractures (2004)

This article presents a minimally invasive adaptation of the sliding hip screw technique. This two-hole side plate construct for the repair of intertrochanteric hip fractures minimizes blood loss and soft-tissue dissection.
Synthesis and Properties of Hexafluoroisopropylidenecontaining Polyarylates and Copolyarylates (1991)

A homologous series of four aromatic polyesters and two series of copolyarylates were synthesized under phase-transfer conditions from monomers containing the isopropylidene (IP) and/or the hexafluoroisopropylidene (HFIP) moiety. The homopolymers were obtained in good yields, were soluble in common organic solvents, and would readily form clear, colorless films from solution. Thermal stabilities in air (dynamic-10% weight losses at 440°C-490°C; isothermal-100 h at 350°C, 7%-86% weight loss) revealed that resistance to thermo-oxidation was highest when the HFIP group replaced the IP moiety in the bisphenol rather than in the diacid. Other properties of the homopolymers which were measured were water absorption of 0.07%-0.35% (by weight), and the dielectric constant of 2.32 for the fully fluorinated polymer. Copolymers were prepared from mixtures of bisphenols A and AF, and each of the two diacids. The thermal stability and water absorption of both series were measured as functions of BPAF content. No significant change in properties was observed for copolymers with less than 70 mol.% BPAF comonomer.
Stimulated Desorption of Cations from Pristine and Acidic Low-Temperature Water Ice Surfaces (2004)

Electron-impact ionization of low-temperature water ice leads to H+, H+2, and H+(H2O)(n=1-8) desorption. The 22 eV H+ desorption threshold is correlated with localized 2-hole 1-electron and 2-hole final states which Coulomb explode, while the 22 eV H+2 threshold is due to H2O+ unimolecular dissociation. The 70 eV primary cluster ion threshold is consistent with holes in the 2a(1) level and secondary ionization channels. All cation yields are sensitive to local structural changes and probe surface acidity. The cluster size distribution indicates hole-hole screening distances of 1-2 nm.
Polyurea microcapsules from isocyanatoethyl methacrylate copolymers (2016)

ABSTRACT The synthesis of two types of isocyanate side chain containing copolymers, poly(methyl methacrylate‐ co ‐isocyanatoethyl methacrylate) (P(MMA‐ co ‐IEM)) and poly(benzyl methacrylate‐ co ‐isocyanatoethyl methacrylate) (P(BnMA‐ co ‐IEM)), which were synthesized by Cu(0)‐mediated radical polymerization, is reported. Polymerization proceeded to high conversion giving polymers of relatively narrow molar mass distributions. The incorporation of the bulky aromatic groups in the latter copolymer rendered it sufficiently stable toward hydrolysis and enabled the isolation of the product and its characterization by 1 H and 13 C NMR, and FTIR spectroscopy and SEC. Both P(MMA‐ co ‐IEM) and P(BnMA‐ co ‐IEM) were functionalized with dibutylamine, octylamine, and ( R )‐(+)‐α‐methylbenzyl‐amine, which further proved the successful incorporation of the isocyanate groups. Furthermore, P(BnMA‐ co ‐IEM) was used for the fabrication of liquid core microcapsules via oil‐in‐water interfacial polymerization with diethylenetriamine as crosslinker. The particles obtained were in the size range of 10–90 µm in diameter independent of the composition of copolymer. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 2698–2705
High-pulse-energy Q-switched Ho3+:YAG laser (2020)

We report on a high-energy Ho 3 + :YAG laser with a maximum average power of 20 . 1W at a central wavelength of 2 . 09µm and M 2 &lt; 1 . 5. In Q-switched operation a maximum pulse energy of 15mJ at 700Hz repetition rate was achieved.
Resolving conflicts with committing transactions in distributed real-time databases (2002)

In a distributed real-time database system, if data conflicts occur between executing and committing transactions, the performance can be severely affected. In this paper, we propose an approach, called deadline driven conflict resolution (DDCR), which integrates concurrency control and commitment management in resolving data conflicts between executing and committing transactions, while at the same time maintaining the schedules to be serializable. With DDCR, many of the data conflicts can be alleviated, and concurrent execution of transactions is allowed to access data items being held by committing transactions. The impact of temporary failures occurred during the commitment of a transaction on other transactions is reduced by reversing the dependencies between the transactions. Simulation experiments have been performed and the results show that DDCR can significantly improve the system performance especially when the duration for the voting phase is long.
Signalling and regulation of the α1B-adrenergic receptor (1995)

Conference Article| February 01 1995 Signalling and regulation of the α1B-adrenergic receptor S. Cotecchia; S. Cotecchia * *To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar A. L. Lattion; A. L. Lattion 1Institut de Pharmacologie et Toxicologie, Faculté de Médecine, Lausanne, Switzerland Search for other works by this author on: This Site PubMed Google Scholar D. Diviani; D. Diviani 1Institut de Pharmacologie et Toxicologie, Faculté de Médecine, Lausanne, Switzerland Search for other works by this author on: This Site PubMed Google Scholar A. Cavalli A. Cavalli 1Institut de Pharmacologie et Toxicologie, Faculté de Médecine, Lausanne, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (1): 121–125. https://doi.org/10.1042/bst0230121 Article history Received: September 05 1994 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation S. Cotecchia, A. L. Lattion, D. Diviani, A. Cavalli; Signalling and regulation of the α1B-adrenergic receptor. Biochem Soc Trans 1 February 1995; 23 (1): 121–125. doi: https://doi.org/10.1042/bst0230121 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: AR, adrenergic receptor, βARK, β-adrenergic receptor kinase, G protein, guanine nucleotide regulatory protein, LH, luteinizing hormone, PI, polyphosphoinositide, PKC, protein kinase C, PLC, phospholipase C, PMA, phorbol 12-myristate 13-acetate, TMD, transmembrane domain, TSH, thyroid-stimulating hormone This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Salt effect on the quality and recovery of essential oil of citronella (Cymbopogon winterianus Jowitt) (2002)

Abstract Four different salts, sodium chloride, calcium chloride, sodium carbonate and calcium carbonate, were used as additives in the distillation of Java citronella to monitor the effect of salts on the quality and recovery of oil. Only calcium chloride was found to enhance the oil yield and the citronellal content with significant reduction in elemol content of the essential oil. Copyright © 2002 John Wiley &amp; Sons, Ltd.
GRP78 protects a disintegrin and metalloprotease 17 against protein‐disulfide isomerase A6 catalyzed inactivation (2017)

The shedding of ectodomains is a crucial mechanism in many physiological and pathological events. A disintegrin and metalloprotease-17 (ADAM17) is a key sheddase involved in essential processes, such as development, regeneration, and immune defense. ADAM17 exists in two conformations which differ in their disulfide connection in the membrane-proximal domain (MPD). Protein-disulfide isomerases (PDIs) on the cell surface convert the open MPD into a rigid closed form, which corresponds to inactive ADAM17. ADAM17 is expressed in its open activatable form in the endoplasmic reticulum (ER) and consequently must be protected against ER-resident PDI activity. Here, we show that the chaperone 78-kDa glucose-regulated protein (GRP78) protects the MPD against PDI-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition.