gebhart/patrepeval huggingface dataset:
High‐sensitivity liquid chromatography–combustion isotope ratio mass spectrometry of fat‐soluble vitamins (1995)

Abstract The sensitivity of high‐precision liquid chromatography/combustion isotope ratio mass spectrometry (LC/C‐IRMS) was improved by more than two orders of magnitude by modifications which permit optimization of flows. The lower limits for high precision are about 3 μg of analyte on‐column for flow injection and LC modes. Pneumatic aerosol spray coating was implemented and compared with simple dip coating. The signal enhancement for aerosol compared with dip coating is up fourfold at higher levels but drops to less than twofold at lower levels, while the dynamic range is extended at higher levels by fourfold at high sample load levels. LC separations for underivatized tocopherols, retinyl acetate and ergocalciferol are demonstrated with precision and accuracy of about δ 13 C &lt; 2.5% for replicates. This work demonstrates sensitivity useful for a wide range of LC analyses and extends high‐precision LC/C‐IRMS to the determination of several fat‐soluble vitamins.
Experiments with QoS-Aware Gaming-on-Demand Service (2006)

This paper presents experiments with an adaptation architecture for a novel client-server based broadband gaming solution, a gaming-on-demand service. The adaptation solution was implemented to an experimental gaming-on-demand setup to evaluate its advantages by measuring adaptation performance under emulated real world network conditions. The obtained results show that the gaming-on-demand service performance is improved significantly when the adaptation solution is used
Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10 (2010)

Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with RET exon 10 mutations for clinical-risk profiles. Presentation, age-dependent penetrance, and stage at presentation of medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism were studied. A total of 340 subjects from 103 families, age 4-86, were registered. There were 21 distinct single nucleotide germline mutations located in codons 609 (45 subjects), 611 (50), 618 (94), and 620 (151). MTC was present in 263 registrants, pheochromocytoma in 54, and hyperparathyroidism in 8 subjects. Of the patients with MTC, 53% were detected when asymptomatic, and among those with pheochromocytoma, 54%. Penetrance for MTC was 4% by age 10, 25% by 25, and 80% by 50. Codon-associated penetrance by age 50 ranged from 60% (codon 611) to 86% (620). More advanced stage and increasing risk of metastases correlated with mutation in codon position (609→620) near the juxtamembrane domain. Our data provide rigorous bases for timing of premorbid diagnosis and personalized treatment/prophylactic procedure decisions depending on specific RET exon 10 codons affected.
ChemInform Abstract: (3.3)Orthocyclophanes with Facing Benzene and Naphthalene Rings. (1988)

Abstract The unsymmetrically substituted bicyclic ketone (Vc) is synthesized as outlined in the reaction scheme.
Adjuvant Treatment of Pancreatic Cancer in 2009: Where Are We? (2009)

Summary Despite attempted curative resection of localized pancreatic adenocarcinoma, most patients succumb a recurrence and die of their disease. The Gastrointestinal Tumor Study Group, European Organization for Research and Treatment of Cancer, and European Study Group for Pancreatic Cancer trials have suggested the benefit of adjuvant therapy. However, the relatively few randomized trials available have not established a definite standard of care due to study limitations. Although these trials, and the recently published Charite Onkologie (CONKO)-001 trial, have shown a definite advantage of adjuvant chemotherapy, the most effective chemotherapy and the role of radiation therapy remain unclear. This review will discuss the data available from reported trials of adjuvant therapy in pancreatic cancer, especially the results of the ESPAC-3 study presented at the annual meeting of ASCO 2009, and consider future directions for clinical trials.
Detection of Explosives Vapors with a Portable Detector Based on Quartz-Crystal Microbalance (2007)

This paper presents the development of a portable gas sensor device prototype able to detect explosives vapors as 2,4 dinitrotoluene (DNT). This detector is based on a single polymer coated quartz crystal microbalance and an appropriate data processing implemented on a microcontroller. Several polymeric materials have been chosen and their sensitivity performances have been evaluated to determinate the most suitable material for DNT detection. This device offers a great sensitivity for DNT exposures (150 Hz/ppm), but this one is also selective towards interfering solvents exposures (< 1 Hz/ppm), independently from temperature and moist conditions.
The 3.0GHz 64-thread SPARC T4 processor (2012)

The SPARC T4 processor introduces the next generation multi-threaded S3 core and delivers a significant single-thread performance improvement over its predecessor. The chip integrates eight S3 cores, an 8-Bank 4MB L3 Cache, a 768GB/sec crossbar, a memory controller, PCI Gen2.0, 10G Ethernet and a cache coherency controller with 2.4Tb/s highspeed I/Os. The dual-issue, out-of-order execution core features a 16-stage integer pipeline, extensive branch predictions, dynamic threading and an enhanced cryptographic processing unit. The 406mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die is fabricated in TSMC's 40nm process and contains 855million transistors and 2.6million flip-flops in a flipchip ceramic package. Enhanced physical design methodologies and extensive power management features enable 3.0GHz operation in the same power envelope of its predecessor.
HOXA9 Overexpression Contributes to Stem Cell Overpopulation That Drives Development and Growth of Colorectal Cancer (2022)

HOX proteins are transcription factors that regulate stem cell (SC) function, but their role in the SC origin of cancer is under-studied. Aberrant expression of HOX genes occurs in many cancer types. Our goal is to ascertain how retinoic acid (RA) signaling and the regulation of <i>HOXA9</i> expression might play a role in the SC origin of human colorectal cancer (CRC). Previously, we reported that aldehyde dehydrogenase (ALDH) and other RA pathway components are co-expressed in colonic cancer SCs (CSCs) and that overpopulation of ALDH-positive CSCs occurs during colon tumorigenesis. Our hypothesis is RA signaling regulates HOXA9 expression, and dysregulated RA signaling results in HOXA9 overexpression, which contributes to CSC overpopulation in CRC. Immunostaining showed that HOXA9 was selectively expressed in ALDH-positive SCs, and HOXA9 expression was increased in CRCs compared to normal epithelium. Modulating RA signaling in CRC cells (HT29 and SW480) with ATRA and DEAB decreased cell proliferation and reduced HOXA9 expression. Bioinformatics analyses identified a network of proteins that functionally interact with HOXA9, and the genes that encode these proteins, as well as <i>HOXA9</i>, contain RA receptor binding sites. These findings indicate that the expression of HOXA9 and its functional network is regulated by RA signaling in normal colonic SCs, and, when dysregulated, HOXA9 may contribute to CSC overpopulation that drives CRC development and growth. Our study provides a regulatory mechanism that might be useful in developing treatments against CSC overpopulation in CRC.
Myosin heavy chain and cardiac troponin T damage is associated with impaired myofibrillar ATPase activity contributing to sarcomeric dysfunction in Ca2+-paradox rat hearts (2017)

This study aimed to explore the potential contribution of myofibrils to contractile dysfunction in Ca<sup>2+</sup>-paradox hearts. Isolated rat hearts were perfused with Krebs-Henseleit solution (Control), followed by Ca<sup>2+</sup>-depletion, and then Ca<sup>2+</sup>-repletion after Ca<sup>2+</sup>-depletion (Ca<sup>2+</sup>-paradox) by Langendorff method. During heart perfusion left ventricular developed pressure (LVDP), end-diastolic pressure (LVEDP), rate of pressure development (+ dP/dt), and pressure decay (-dP/dt) were registered. Control LVDP (127.4 ± 6.1 mmHg) was reduced during Ca<sup>2+</sup>-depletion (9.8 ± 1.3 mmHg) and Ca<sup>2+</sup>-paradox (12.9 ± 1.3 mmHg) with similar decline in +dP/dt and -dP/dt. LVEDP was increased in both Ca<sup>2+</sup>-depletion and Ca<sup>2+</sup>-paradox. Compared to Control, myofibrillar Ca<sup>2+</sup>-stimulated ATPase activity was decreased in the Ca<sup>2+</sup>-depletion group (12.08 ± 0.57 vs. 8.13 ± 0.19 µmol P<sub>i</sub>/mg protein/h), besides unvarying Mg<sup>2+</sup> ATPase activity, while upon Ca<sup>2+</sup>-paradox myofibrillar Ca<sup>2+</sup>-stimulated ATPase activity was decreased (12.08 ± 0.57 vs. 8.40 ± 0.22 µmol P<sub>i</sub>/mg protein/h), but Mg<sup>2+</sup> ATPase activity was increased (3.20 ± 0.25 vs. 7.21 ± 0.36 µmol P<sub>i</sub>/mg protein/h). In force measurements of isolated cardiomyocytes at saturating [Ca<sup>2+</sup>], Ca<sup>2+</sup>-depleted cells had lower rate constant of force redevelopment (k <sub>tr,max</sub>, 3.85 ± 0.21) and unchanged active tension, while those in Ca<sup>2+</sup>-paradox produced lower active tension (12.12 ± 3.19 kN/m<sup>2</sup>) and k <sub>tr,max</sub> (3.21 ± 23) than cells of Control group (25.07 ± 3.51 and 4.61 ± 22 kN/m<sup>2</sup>, respectively). In biochemical assays, α-myosin heavy chain and cardiac troponin T presented progressive degradation during Ca<sup>2+</sup>-depletion and Ca<sup>2+</sup>-paradox. Our results suggest that contractile impairment in Ca<sup>2+</sup>-paradox partially resides in deranged sarcomeric function and compromised myofibrillar ATPase activity as a result of myofilament protein degradation, such as α-myosin heavy chain and cardiac troponin T. Impaired relaxation seen in Ca<sup>2+</sup>-paradoxical hearts is apparently not related to titin, rather explained by the altered myofibrillar ATPase activity.
Error-free milestones in error prone measurements (2009)

A predictor variable or dose that is measured with substantial error may possess an error-free milestone, such that it is known with negligible error whether the value of the variable is to the left or right of the milestone. Such a milestone provides a basis for estimating a linear relationship between the true but unknown value of the error-free predictor and an outcome, because the milestone creates a strong and valid instrumental variable. The inferences are nonparametric and robust, and in the simplest cases, they are exact and distribution free. We also consider multiple milestones for a single predictor and milestones for several predictors whose partial slopes are estimated simultaneously. Examples are drawn from the Wisconsin Longitudinal Study, in which a BA degree acts as a milestone for sixteen years of education, and the binary indicator of military service acts as a milestone for years of service.
Selective Electrolytic Removal of Bis(alkoxycarbonyl)methano Addends from C60 Bis-adducts and Electrochemical Stability of C70 Derivatives (2000)

The novel mixed bis-adducts of C60, (+/-)-4-(+/-)-8 and 9, with a bis(ethoxycarbonyl)methano addend (Bingel addend) and a second addend ([1,2]benzeno, but[2]eno, methaniminomethano, or diarylmethano) bridging 6,6-closed bonds of the carbon sphere were synthesized in two-step reactions. Each bis-adduct was exhaustively electrolyzed at the potential of the second fullerene-centered reduction step, resulting in the selective removal of the Bingel addend (retro-Bingel reaction) to produce the corresponding mono-adducts, which were isolated in yields of over 60%. These results open up the possibility of using the Bingel addend as a temporary protecting and directing group in the construction of multiple adducts of C60 with unusual addition patterns. The Bingel-type mono-adduct of C70 10 and the constitutionally isomeric bis-adducts 11, (+/-)-12, and (+/-)-13 were also included in this investigation. A large difference in the electrochemical behavior between C70 bis-adducts and the corresponding C60 derivatives was observed. Thus, the intramolecular "walk-on-the-sphere" isomerization which occurs readily with Bingel-type bis-adducts of C60 under the conditions of two-electron controlled potential electrolysis (CPE) is only a minor reaction pathway in the series of C70 derivatives. The latter preferentially undergo retro-Bingel reaction.
Topography of Genetic Loci in Tissue Samples: Towards New Diagnostic Tool Using Interphase FISH and High‐Resolution Image Analysis Techniques (2000)

Using single and dual colour fluorescence in situ hybridisation (FISH) combined with image analysis techniques the topographic characteristics of genes and centromeres in nuclei of human colon tissue cells were investigated. The distributions of distances from the centre-of-nucleus to genes (centromeres) and from genes to genes (centromeres to centromeres) were studied in normal colon tissue cells found in the neighbourhood of tumour samples, in tumour cell line HT-29 and in promyelocytic HL-60 cell line for comparison. Our results show that the topography of genetic loci determined in 3D-fixed cell tissue corresponds to that obtained for 2D-fixed cells separated from the tissue. The distributions of the centre-of-nucleus to gene (centromere) distances and gene to gene (centromere to centromere) distances and their average values are different for various genetic loci but similar for normal colon tissue cells, HT-29 colon tumour cell line and HL-60 promyelocytic cell line. It suggests that the arrangement of genetic loci in cell nucleus is conserved in different types of human cells. The investigations of trisomic loci in HT-29 cells revealed that the location of the third genetic element is not different from the location of two homologues in diploid cells. We have shown that the topographic parameters used in our experiments for different genetic elements are not tissue or tumour specific. In order to validate high-resolution cytometry for oncology, further investigations should include more precise parameters reflecting the state of chromatin in the neighbourhood of critical oncogenes or tumour suppresser genes.
On-wafer time-domain characterization of power GaN HEMTs for accurate nonlinear modeling of thermal and trapping effects and their impacts on pulse to pulse reliability (2018)

International audience
Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review (2020)

Ezrin, as encoded by the EZR gene, is a member of the Ezrin/Radixin/Moesin (ERM) family. The ERM family includes three highly related actin filament binding proteins, Ezrin, Radixin, and Moesin. These three members share similar structural properties containing an N-terminal domain named FERM, a central helical linker region, and a C-terminal domain that mediates the interaction with F-actin. Ezrin protein is highly regulated through the conformational change between a closed, inactivate form and an open, active form. As a membrane-cytoskeleton linker protein, Ezrin facilitates numerous signal transductions in tumorigenesis and mediates diverse essential functions through interactions with a variety of growth factor receptors and adhesion molecules. Emerging evidence has demonstrated that Ezrin is an oncogene protein, as high levels of Ezrin are associated with metastatic behavior in various types of cancer. The diverse functions attributed to Ezrin and the understanding of how Ezrin drives the deadly process of metastasis are complex and often controversial. Here by reviewing recent findings across a wide spectrum of cancer types we will highlight the structures, protein interactions and oncogenic roles of Ezrin as well as the emerging therapeutic agents targeting Ezrin. This review provides a comprehensive framework to guide future studies of Ezrin and other ERM proteins in basic and clinical studies.
On turbulence modeling for unsteady transonic flows (1979)

A detailed examination of the turbulent field in an unsteady transonic flow undergoing shock-induced separation is conducted. Ensemble-averaged mean and fluctuating velocities, obtained from conditionally sampled laser velocimeter data, are described and analyzed to assess the applicability of modeling concepts usually employed in steady-flow problems. Some comparisons with computations employing the Reynolds averaged Navier-Stokes equations with a mixing length turbulence model are then presented to illustrate the status of current predictive capabilities. The results appear to imply that turbulence models developed for steady flows apply and that the model need not reflect all the fine details of the turbulent structure but rather account in an approximate way for the production and destruction of the turbulence.
Finite bandwidth and space charge effects in the MUSE model (2002)

Summary form only given. We have recently developed a new one-dimensional nonlinear model of a Traveling Wave Tube (TWT) being driven by an input signal with multiple frequencies. The MUltifrequency Spectral Eulerian (MUSE) model is ideally suited to predict the pre-saturation evolution of drive, harmonic, and intermodulation frequencies when there are many closely-spaced drive frequencies. The primary benefits of MUSE include reduced computation time for dense input spectra and enhanced analytic tractability over the conventional "disk" model. Since MUSE uses an Eulerian description of the electron beam it can not predict saturation accurately. However, the model is of practical use since TWTs are often driven with backed off input levels during multifrequency excitation so that they do not saturate. The first formulation of MUSE did not incorporate a frequency dependent cold circuit phase velocity, frequency dependent interaction impedance, or beam space charge. In this paper we present an enhanced MUSE model that accounts for these physical effects. Several test cases are presented and compared with a disk model. Additionally, we discuss the foundation of the MUSE model and comment on some physical insights elucidated by the model.
Supplementary Table 6 from Using a Stem Cell–Based Signature to Guide Therapeutic Selection in Cancer (2023)

Supplementary Table 6 from Using a Stem Cell–Based Signature to Guide Therapeutic Selection in Cancer
Computer aided weld seam tracking approach (2017)

Purpose This paper aims to automate the welding operation that motion control, sensor integration and coordination with the welding power source. Therefore, there is a need for sophisticated technologies to control precisely the process in terms of positioning the welding torch, and controlling the welding parameters through the use of correct devices which are aided by appropriate control tools and techniques. Design/methodology/approach A new seam tracking methodology, named sewing technique, has been introduced for the welded joints available in computer-aided design (CAD) environment. This methodology gives the seam path by drawing a line through the adjacent centroids of curve fitted in the weld joint volume. Obtained geometric path and kinematic constraints are given as input to the modeled robot for performing welding operation followed by desired trajectory. Findings In this investigation, a novel and efficient weld seam technique has been developed to produce uniform welded joints. The key feature of this approach is that the initial and end positions of the weld seams can be obtained easily. Because of this, the robot can be controlled flexibly during welding operation. Originality/value This investigation deals with the development of an automated seam tracking methodology for the welded joints available in CAD environment. Validation of the developed methodology has been done through simulation results while performing welding operations for different weld profiles.
Cosine-Gauss Plasmon Beam: A Localized Long-Range Nondiffracting Surface Wave (2012)

A new surface wave is introduced, the cosine-Gauss beam, which does not diffract while it propagates in a straight line and tightly bound to the metallic surface for distances up to 80 μm. The generation of this highly localized wave is shown to be straightforward and highly controllable, with varying degrees of transverse confinement and directionality, by fabricating a plasmon launcher consisting of intersecting metallic gratings. Cosine-Gauss beams have potential for applications in plasmonics, notably for efficient coupling to nanophotonic devices, opening up new design possibilities for next-generation optical interconnects.
Toxicity of Bacillus thuringiensis Spore and Crystal Protein to Resistant Diamondback Moth (Plutella xylostella) (1996)

A colony of Plutella xylostella from crucifer fields in Florida was used in mortality bioassays with HD-1 spore, CryIA(a), CryIA(b), CryIA(c), CryIB, CryIC, CryID, CryIE, or CryIIA. The data revealed high levels of field-evolved resistance to HD-1 spore and all CryIA protoxins and no resistance to CryIB, CryIC, or CryID. CryIE and CryIIA were essentially not toxic. When HD-1 spore was combined 1:1 with protoxin and fed to susceptible larvae, spore synergized the activity of CryIA and CryIC 5- to 8-fold and 1.7-fold, respectively, and did not synergize the mortality of CryIIA. When fed to Florida larvae, spore failed to synergize the activity of all three CryIA protoxins, synergized the activity of CryIC 5.3-fold, and did not synergize the mortality for CryIIA. Binding studies with CryIA(b), CryIB, and CryIC were performed to determine possible mechanisms of resistance. The two techniques used were (i) binding of biotinylated toxin to tissue sections of larval midguts and (ii) binding of biotinylated toxin to brush border membrane vesicles prepared from whole larvae. Both showed dramatically reduced binding of CryIA(b) in resistant larvae compared with that in susceptible larvae but no differences in binding of CryIB or CryIC.
Retrospective chart review and survey to identify adverse safety events in the emergency medical services care of children with out-of-hospital cardiac arrest in the USA: a study protocol (2020)

This study has been approved by the Oregon Health & Science University Institutional Review Board (IRB Approval# 00018748). Study results will be disseminated through scientific publications and presentations, and to EMS leaders and staff through local EMS medical directors, quality and training officers and community engagement activities.
LTE Experimental validation in a Gas Metal Arc Welding plasma column (2011)

[Post-Publication PLASMA 2010]