gebhart/patrepeval huggingface dataset:
Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster (2016)

The composition of the intestinal microbiota of Drosophila has been studied in some detail in recent years. Environmental, developmental and host-specific genetic factors influence microbiome composition in the fly. Our previous work has indicated that intestinal bacterial load can be affected by chromatin-targeted regulatory mechanisms. Here we studied a potential role of the conserved chromatin assembly and remodeling factor CHD1 in the shaping of the gut microbiome in Drosophila melanogaster. Using high-throughput sequencing of 16S rRNA gene amplicons, we found that Chd1 deletion mutant flies exhibit significantly reduced microbial diversity compared to rescued control strains. Specifically, although Acetobacteraceae dominated the microbiota of both Chd1 wild-type and mutant guts, Chd1 mutants were virtually monoassociated with this bacterial family, whereas in control flies other bacterial taxa constituted ~20% of the microbiome. We further show age-linked differences in microbial load and microbiota composition between Chd1 mutant and control flies. Finally, diet supplementation experiments with Lactobacillus plantarum revealed that, in contrast to wild-type flies, Chd1 mutant flies were unable to maintain higher L. plantarum titres over time. Collectively, these data provide evidence that loss of the chromatin remodeler CHD1 has a major impact on the gut microbiome of Drosophila melanogaster.
Electrodermal activity in suicidal and nonsuicidal depressive patients and in matched healthy subjects (1987)

The electrodermal activity (EDA) was measured in 25 suicidal and 34 nonsuicidal depressive patients and 59 individually matched healthy subjects during stimulation with neutral tone stimuli. Suicidal behaviour, especially the occurrence of attempts, was related to low electrodermal responsivity (EDR) and low stimulus-unrelated phasic activity, but unrelated to tonic EDA. The EDR of different groups of subjects was successfully illustrated and tested by statistical methods known as survival statistics. The extreme hyporesponsivity in the attempters was observed irrespective of whether the attempt had been made previously or during the current depression. Electrodermal hyporesponsivity among depressive patients may be a part of a mechanism operating in the suicidal process, and an expression for a factor related to the ability to carry out a suicide attempt. This nonverbal and noninvasive method may yield additional valuable information when estimating the suicide risk in depressive patients in clinical work.
Carcinogenicity and polarographic behaviour of dibenzo[a,h]pyrene, 4,11-diazadibenzo[a,h]pyrene and 7,14-diazadibenzo[a,h]pyrene. (1979)

In a simultaneous test of carcinogenicity the writers have studied the activities of dibenzo[a,h]pyrene (I), 4,11-diazadibenzo[a,h]pyrene (II) and 7,14-diazadibenzo[a,h]pyrene (III). These compounds were dispersed in paraffin disks and subcutaneously implanted in rats. Each experimental group consisted of 30 animals. The number of sarcomas induced by (I) and (II) was 23 and 16 respectively. The compound (III) has proved wholly inactive. Tumorigenicity of (I) and (II) was found to be proportional to their electron donation and inversely proportional to their electron acceptance in the performed polarographic test. Inactivity of (III) is being discussed from the aspect of molecular geometry.
Local Force and Deformation Calculation using the 2D Finite Element Method (1997)

COMPUMAG'97
Processing and Characterization of Electrolytes Based on Doped Lanthanum Gallates for IT-SOFCs. (2004)

peer reviewed
Pulse shaping during laser percussion drilling by using fiber laser radiation (2012)

Laser percussion drilling is commonly used for drilling holes such as cooling holes in the aerospace industry. Flash lamp pumped Nd:YAG laser sources are state of the art for drilling. For a short time pulsed diode pumped laser sources such as fiber lasers with high average power are available coming along with benefits due to the productivity and reproducibility of drilled holes [1]. Pulse shaping can be done easily with these laser sources. The temporal intensity distribution of each pulse - intrapulse shaping - and the intensity in a sequence of pulses - interpulse shaping - can be modulated by the laser control software. The temporal intensity distribution using intrapulse shaping has no visible influence on the drilling results. The same energy is required to get a through hole. Thus using rectangular pulses which can be emitted by fiber lasers the pulse peak power can be lower. Using interpulse shaping by increasing the pulse peak power within a sequence of pulses the hole geometry can be modified due to a smaller diameter and a rectangular hole entrance. Furthermore the spatter on the workpiece surface is less and can be removed by wiping by hand. Thus economic benefits are established by using pulse shaping during laser percussion drilling with fiber lasers due to lower required pulse peak power and the disappearance of finishing steps like grinding.
A Statistical Design Rule Developer (1986)

In this paper, a general methodology for design rule development and the CAD tool which implements this methodology, Statistical Design Rule Developer (STRUDEL), are presented. The focus of the proposed approach is the concept of a statistical design rule, which is defined as a geometric design rule with an associated probability of failure. Global lateral variations obtained from FABRICS, and local spot defects obtained from measurements are taken into account when calculating the probability of failure. A failure model which accounts for catastrophic faults has been enhanced to include some parametric faults. STRUDEL can be used as a guide to generate layout design rules and may be extended to a wide range of applications including coarse yield estimation during design rules check.
Activation of the ErbB3-AKT axis promotes melanoma cell survival and proliferation in response to RAF/MEK inhibition (2014)

Background Therapy of advanced melanoma has been improved with the advent of BRAF inhibitors. However, a limitation to such treatment is the occurrence of resistance. Several mechanisms have been implied in the development of resistance, which in most cases lead to downstream MEK reactivation. In order to overcome resistance MEK inhibitors are being clinically developed with promising results. However, also in this case resistance inevitably occurs. It is commonly believed that the establishment of resistance is facilitated by adaptive changes that take place in cancer cells shortly after exposure to kinase inhibitors. Our laboratory is interested in the identification of these early adaptive changes with the intent to discover additional targets for therapeutic intervention. Methods
Operational Experiences Related to Severe Turbulence Between September 1973 and August 1975 (1976)

This paper represents the severe turbulence data encountered by civil transports between September 1973 and August 1975.This programme was conducted in accordance with the task assigned to the members in the repost of the 10th Meeting of ICAO Airworthiness Committee,paragraphy 6:3.3(6),and the flight recorder data in excess of 1g incremental acceleration were collected by the airlines.Six events were obtained in total,one of which ha
Neville Moray (1935–2017) (2018)

Research Article| October 01 2018 Neville Moray (1935–2017) Peter Hancock; Peter Hancock Department of Psychology and Institute for Simulation and Training, University of Central Florida, Orlando, FL 32816, E-mail: peter.hancock@ucf.edu Search for other works by this author on: This Site Google John Senders; John Senders University of Toronto (Emeritus) Search for other works by this author on: This Site Google John Lee John Lee University of Wisconsin Search for other works by this author on: This Site Google The American Journal of Psychology (2018) 131 (3): 381–384. https://doi.org/10.5406/amerjpsyc.131.3.0381 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Peter Hancock, John Senders, John Lee; Neville Moray (1935–2017). The American Journal of Psychology 1 January 2018; 131 (3): 381–384. doi: https://doi.org/10.5406/amerjpsyc.131.3.0381 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressThe American Journal of Psychology Search Advanced Search The text of this article is only available as a PDF. Copyright 2018 by the Board of Trustees of the University of Illinois2018 Article PDF first page preview Close Modal Issue Section: IN MEMORIAM You do not currently have access to this content.
Study of Super Olefine Polymer by the Control of Nano-Order Structure I. Mechanical Properties and Morphology of the Polypropylene and Ethylene-Propylene Rubber Blends. (1993)

従来, 自動車用バンパーなどには, 耐衝撃性ポリプロピレンにエチレンプロピレンゴム (EPR) が20～30wt%添加された材料が広く使用されている. この種の材料においては, その量比からポリプロピレン (PP) の海にEPRが島として存在するとする考え方が定説であった. しかし, そのような考え方では物性の解釈が困難な場合があり, 今回, 高分解能電子顕微鏡観察, 粘弾性解析, パルスNMRなどにより詳細な構造解析を実施した. その結果, EPRの一部とPP非晶部とが相互溶解して一体となりエラストマ-化するとともに, 三次元的に連結しているEPR相が存在することがわかった. 結論として, この種の材料の構造は従来の定説であるPPマトリックスにEPRが分散する構造ではなく, PP非晶相とエラストマーから成るマトリックス中にPP結晶ラメラが分散する構造であること, および, その構造モデルによって, 従来は説明困難であった物性の解釈が可能となることが判明した.
Neutralizing and non-neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patient (2010)

HMAbs against DENV can be successfully generated by EBV transformation of B cells from patients at least two years after naturally acquired DENV infections. These antibodies show different patterns of cross-reactivity, neutralizing, and enhancement activity.
Acetylene as a Driving and Organizing Molecule in One‐Pot Transition‐Metal‐Free Synthesis of Furans using Chalcones and their Analogues (2017)

Abstract Acetylene reacts with chalcones and their heterocyclic analogues in NaO t Bu/DMSO catalytic system (70 °C, 15 min) to afford substituted furans in a yield of up to 85 %, thus providing a simple and technologically feasible access to rare furan compounds.
Determination of Gentamicin Residual in Duck Meat Using Fluorescence Analysis Method (2014)

Gentamicin is a kind of aminoglycoside antibiotics and widely used in the prevention and treatment of the duck diseases. A prediction model was established for the rapid detection of Gentamicin residue in duck meat using fluorescence analysis method according to the strong fluorescent characteristic of the generated derivative for Gentamicin and o-phthaldialdehyde (OPA) in the presence of emulsifier OP-10 and mercaptoethanol.The fluorescence spectra of the duck meat containing Gentamicin were analyzed, the optimum excitation wavelength of the material was 340 nm and the optimum emission wavelength was 442 nm. Fluorescence intensity and the concentration of the standard samples presented the good linear relationship, the linear correlation coefficient was 0.9963 and the limit of detection was 0.47 μg/mL in the dynamic rang of 0.5 ~6.5μg/mL. The correlation coefficient of regression equation was 0.9968 for the samples of duck meat extract. The experimental results showed that the fluorescence analysis method had a good performance and accuracy in detecting the Gentamicin residue in duck meat.
Oxidation of Methionine 77 in Calmodulin Alters Mouse Development and Behavior (2018)

Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown. We therefore created a mutant mouse in which wild-type calmodulin-1 was replaced by a calmodulin containing a mimic of methionine sulfoxide at residue 77. Total calmodulin levels were unchanged in the homozygous M77Q mutant, which is viable and fertile. No differences were observed on learning tests, including the Morris water maze and associative learning. Cardiac stress test results were also the same for mutant and wild type mice. .However, young male and female mice were 20% smaller than wild type mice, although food intake was normal for their weight. Young M77Q mice were notably more active and exploratory than wild type mice. This behavior difference was objectively documented on the treadmill and open field tests. The mutant mice ran 20% longer on the treadmill than controls, and in the open field test, the mutant mice explored more than controls and exhibited reduced anxiety These phenotypic differences bore a similarity to those observed in mice lacking calcium/calmodulin kinase Ii&amp;alpha; (CaMKII&amp;alpha;). We then showed that M77Q calmodulin was less effective in activating CaMKII&amp;alpha; than wild type calmodulin. Thus, characterization of the phenotype of a mouse expressing a constitutively active mimic of calmodulin led to the identification of the first calmodulin target that can be differentially regulated by the oxidation state of Met77. We conclude that reversible oxidation of methionine 77 in calmodulin by MSRA can regulate cellular function.
A SIMPLE AND RAPID PLASMINOGEN ACTIVATOR INHIBITOR (PAI) ASSAY IN PLASMA, USING A UNIQUE CONCENTRATION OF TISSUE PLASMINOGEN ACTIVATOR (tPA) AND PAI-DEPLETED PLASMA (1987)

Interferences of plasmin inhibitors are a main drawback in the functional assay of PAI in plasma. To overcome them, an acidification step, prior to residual tPA assay has been frequently used. A simple chromogenic method, based on the inhibition of purified tPA by plasma prediluted in PAI-depleted plasma, is described. The residual tPA was subsequently measured in the presence of fibrinogen fragments used as Stimulator, plasminogen and chromogenic substrate (CBS 30.41). The assay can discriminate between PAI and plasmin inhibitors since the concentration of these proteins remains constant because brought in excess by the PAI-depleted plasma. Parallel dose-response curve were obtained when PAI-depleted plasma was used instead of buffer, for the preparation of the reference curve and for the dilution of samples. The residual tPA activity measured was directly proportional to the PAI activity of the sample using a single concentration of tPA. Samples containing 0 to 30 IU/ml of PAI could be measured using a 1:40 dilution. Values for 27 normal volunteers at rest were 5.1 IU/ml (range : 0 to 11.8 IU/ml). PAI activity was decreased in afternoon samples (4.6 IU/ml) compared to those of the morning (5.8 IU/ml). After stasis, when a concomitant release of tPA was observed, the values obtained (3.1 IU/ml) were significantly lower than the values obtained before (4.1 IU/ml). The activity measured is probably related to PAI-1 (endothelial ceil type PAI), but PAI-2 related activity (placental PAI) can be also estimated since pregnancy plasma showed high levels of inhibitor (mean : 15.1 IU/ml, range : 9.5 to 28.1 IU/rni). The present method is simple and rapid to perform. It can be routinely used in the screening of various thrombotic disorders.
Selective Pseudocapacitive Deionization of Calcium Ions in Copper Hexacyanoferrate (2020)

In recent years, the capacitive deionization (CDI) technology has gradually become a promising technology for hard water treatment. Up to now, most of the work for water softening in CDI was severely limited by the inferior selectivity and electrosorption performances of carbon-based electrodes in spite of combining Ca<sup>2+</sup>-selective ion-exchange resin or membranes. Pseudocapacitive electrode materials that selectively interact with specific ions by Faradic redox reactions or ion (de)intercalation offer an alternative strategy for highly selective electrosorption of Ca<sup>2+</sup> from water because of brilliant ion adsorption capacity. Here, we first used copper hexacyanoferrate (CuHCF) as a pseudocapacitive electrode to methodically study the selective pseudocapacitive deionization of Ca<sup>2+</sup> over Na<sup>+</sup> and Mg<sup>2+</sup>. Using the hybrid CDI cell consisting of a CuHCF cathode and an activated carbon anode without any ion-exchange membrane, the outstanding Ca<sup>2+</sup> electrosorption capacity of 42.8 mg·g<sup>-1</sup> and superior selectivity &(Ca<sup>2+</sup>/Na<sup>+</sup>) of 3.05 at a molar ratio of 10:1 were obtained at 1.4 V, surpassing those of the reported carbon-based electrodes. Finally, electrochemical measurements and molecular dynamics (MD) simulations provided an in-depth understanding of the selective pseudocapacitive deionization of Ca<sup>2+</sup> ions in a CuHCF electrode. Our study would be helpful for developing high-efficiency selective electrosorption of target charged ions by intrinsic properties of pseudocapacitive materials.
Effects of Si doping on normal incidence InAs∕In0.15Ga0.85As dots-in-well quantum dot infrared photodetectors (2006)

The effects of doping on InAs∕In0.15Ga0.85As quantum dots-in-well infrared photodetectors have been studied by measuring the dark current, photocurrent, and spectral response. A significant reduction of dark current with decrease in doping concentration in the quantum dots has been observed. However, the photocurrent of the detectors increases with the doping. By measuring the background limited infrared photodetector temperature, we find that the optimum sheet doping concentration in these detectors is n=3×1010cm−2 (corresponding to about one electron per dot).
Bandgap-tunable lateral and vertical heterostructures based on monolayer Mo1-xWxS2 alloys (2015)

合金，经常甚至在轻轻的条件下面降级，被涂层完成有另外的单层的合金。现在的调查结果表明学习并且优化基于 TMDC 的 heterostructures 的光、电的性质在未来设备应用允许材料的使用的一个有效工具。
Light-induced modification of a-SiOx II: Laser crystallization (2004)

Amorphous hydrogenated silicon suboxides (a-SiOx:H) were deposited by plasma enhanced chemical vapor deposition from the source gases SiH4, H2, and CO2. The band gap of the samples can be tuned from 1.9 to 3.0 eV by varying the oxygen content from 0 to 50 at. %. H-effused samples were irradiated by ultraviolet laser pulses with intensities up to 480 mJ/cm2. The structural changes and the crystallization behavior were investigated as a function of oxygen content and laser intensity. A decrease of the melting threshold by a factor of two with increasing oxygen content (0–44 at. %) was observed for the SiOx samples. Above the respective melting thresholds, not only a deterioration of the structural properties but also indications of a segregation of Si crystallites were found. Raman spectroscopy and transmission electron microscopy gave evidence for the existence of Si crystallites up to oxygen contents of 40 at. %. The crystal size reached an optimum for oxygen concentrations between 10 and 30 at. %.
Reexamination of PDC Bit Walk in Directional and Horizontal Wells (2008)

Abstract This paper describes several mechanisms of PDC bit walk in directional wells drilled by steerable systems and how these mechanisms can be numerically modeled. The developed computer model calculates bit walk rate and walk force with consideration for bit gauge geometry, hole size, formation compressive strength, steering mechanism of the RSS, bit rotational speed, penetration rate and dogleg severity. Application of the model in Alaskan horizontal wells has revealed that an oversized hole and the bit tilt motion are major causes of the bit walk. A matched bit/RSS system is then provided and the results are very successful: bit walk to the right is avoided and bit steerability is increased significantly.
Nitrosyl Iron(II) Complex of meso-Tetrakis(α,α,α,α-o-pivalamidophenyl)porphyrin with a Covalently Linked 2-Methylimidazolylalkyl Group (2000)

Abstract meso-Tetrakis(α,α,α,α-o-pivalamidophenyl)porphinatoiron(II) with an intramolecularly bound 2-methylimidazole forms a six-coordinate nitrosyl complex in toluene at 298 K, which is revealed by ESR and IR spectroscopy; the NO-binding affinity (P1/2) is 1.8 × 10−8 Torr and the association rate constant (kon) is 8.9 × 108 M−1s−1.
Inhibition of IFN-γ-Induced STAT1 Tyrosine Phosphorylation by Human CMV Is Mediated by SHP2 (2008)

Human CMV (HCMV) is a ubiquitous beta-herpesvirus which has developed several mechanisms of escape from the immune system. IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-Tyr), and its binding to IFN-gamma activation site sequences of IFN-gamma-inducible promoters. Activation of those promoters leads to the expression of genes involved in the immune response and in the antiviral effects of IFN-gamma. Src homology region 2 domain-containing phosphatase 2 (SHP2) is a ubiquitous phosphatase involved in the regulation of IFN-gamma-mediated tyrosine phosphorylation. Several mechanisms account for the inhibition IFN-gamma signaling pathway by HCMV. In this study, we have identified a new mechanism that involved the inhibition of STAT1 tyrosine phosphorylation within 12-24 h postinfection. This defect was dependent on HCMV transcription. Consequences were impaired nuclear translocation of STAT1-P-Tyr, inhibition of IFN-gamma activation site-STAT1 interaction, and inhibition of HLA-DR expression. Expression of indoleamine-2,3-dioxygenase which is involved in the antiviral effects of IFN-gamma was also inhibited. Treatment of cells with sodium orthovanadate rescued STAT1 tyrosine phosphorylation, suggesting that a tyrosine phosphatase was involved in this inhibition. Coimmunoprecipitation of STAT1 and SHP2 was induced by HCMV infection, and SHP2 small interfering RNA restored the expression of STAT1-P-Tyr. Our data suggest that SHP2 activation induced by HCMV infection is responsible for the down-regulation of IFN-gamma-induced STAT1 tyrosine phosphorylation.
Cross-cultural cognition and online information design: identifying cognitive styles among web designers of diverse national origin (2005)

There are vast differences in the way people think, behave, assign value, and interact on the Internet. As a result, culture becomes an increasingly relevant area for Internet researchers to investigate how information should be designed for a cross-cultural audience. Numerous studies in computer-mediated communication (CMC) have identified links among culture, user preferences, and Web usability. Most of these studies were reports of findings from a behavioral perspective in explaining how cultural factors affect processes of Web-related content design and use. Based on the research of Vygotsky and Nisbett, this author proposed a broader model by which Web design, like other types of information production, is seen as being shaped by cultural cognitive processes that impact the designers' cognitive style. This dissertation was an exploration of issues related to Web designers' cultural cognitive styles and their impact on user responses. The author posited that a number of measures would show that American 1 and Chinese users would respond to Web content created by designers from their own cultures with a faster performance speed and higher levels of preference. A two-phase study, using an online and in-lab methodology, resulted in the null hypothesis being rejected for two of three hypotheses. Other results provided insights into the role of emotion, cultural bias, and their influence on the cultural cognitive responses of Web users. 1America(n) always refers to the United States of America throughout this dissertation.