gebhart/patrepeval huggingface dataset:
Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats (2022)

Inflammation-mediated alterations in glutamate neurotransmission constitute the most important pathway in the pathophysiology of various brain disorders. The excessive signalling of glutamate results in excitotoxicity, neuronal degeneration, and neuronal cell death. In the present study, we investigated the relative efficacy of black cumin (<i>Nigella sativa</i>) oil with high (5 % w/w) and low (2 % w/w) thymoquinone content (BCO-5 and BCO-2, respectively) in alleviating ibotenic acid-induced excitotoxicity and neuroinflammation in Wistar rats. It was found that BCO-5 reversed the abnormal behavioural patterns and the key inflammatory mediators (TNF-α and NF-κB) when treated at 5 mg/kg body weight. Immunohistochemical studies showed the potential of BCO-5 to attenuate the glutamate receptor subunits NMDA and GluR-2 along with increased glutamate decarboxylase levels in the brain tissues. Histopathological studies revealed the neuroprotection of BCO-5 against the inflammatory lesions, as evidenced by the normal cerebellum, astrocytes, and glial cells. BCO-2 on the other hand showed either a poor protective effect or no effect even at a 4-fold higher concentration of 20 mg/kg body weight indicating a very significant role of thymoquinone content on the neuroprotective effect of black cumin oil and its plausible clinical efficacy in counteracting the anxiety and stress-related neurological disorders under conditions such as depression and Alzheimer's disease.
Descoberta de Vizinhos Baseada em Vetores de Potencia para Comunicações D2D (2015)

Resumo-No contexto das comunicac es diretas Device-to-Device (D2D), a descoberta de Terminais Mveis (TMs) vizinhos torna-se crucial para que essa comunicac o acontec a.Em vista disso,
Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia (2012)

Given that most bone marrow cells are short-lived, the accumulation of multiple leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). We investigated this model through genomic analysis of HSCs from six patients with de novo acute myeloid leukemia (AML). Using exome sequencing, we identified mutations present in individual AML patients harboring the FLT3-ITD (internal tandem duplication) mutation. We then screened the residual HSCs and detected some of these mutations including mutations in the NPM1, TET2, and SMC1A genes. Finally, through single-cell analysis, we determined that a clonal progression of multiple mutations occurred in the HSCs of some AML patients. These preleukemic HSCs suggest the clonal evolution of AML genomes from founder mutations, revealing a potential mechanism contributing to relapse. Such preleukemic HSCs may constitute a cellular reservoir that should be targeted therapeutically for more durable remissions.
Characterization of thermosetting polymer mortars (1990)

Abstract The behavior of epoxy and polyester mortars were studied under various curing conditions, temperatures, and strain rates. The effect of curing temperatures on the compressive stress–strain relationships of polymers and polymer mortars were also investigated. The properties of interest of the two polymer mortars cured under optimum conditions are the compressive strength, splitting tensile strength, compressive modulus, and compressive stress–strain relationship. The compressive strength of polymer mortars are related to the testing temperature and logarithmic strain rate. The compressive modulus and splitting tensile strength of polymer mortars are related to their compressive strength. A new nonlinear constitutive model is proposed to predict the complete compressive stress–strain behavior of epoxy and polyester polymer mortars.
Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene. (1991)

Complete deficiency of lipoprotein lipase (LPL) causes the chylomicronemia syndrome. To understand the molecular basis of LPL deficiency, two siblings with drastically reduced postheparin plasma lipolytic activities were selected for analysis of their LPL gene. We used the polymerase chain reaction to examine the nine coding LPL exons in the two affected siblings and three relatives. DNA sequence analysis revealed a single nucleotide change compared with the normal LPL cDNA: a G----A substitution at nucleotide position 680. This transition caused a replacement of glutamic acid for glycine at amino acid residue 142 of the mature LPL protein. Amino acid sequence comparisons of the region surrounding glycine-142 indicated that it is highly conserved among lipases from different species, suggesting a crucial role of this domain for the LPL structure. Expression studies of the mutant LPL cDNA in COS-7 cells produced normal amounts of enzyme mass. However, the mutated LPL was not catalytically active, nor was it efficiently secreted from the cells. This established that the Gly----Glu substitution at amino acid 142 is sufficient to abolish enzymatic activity and to result in the chylomicronemia syndrome observed in these patients.
Cell viability screening method using optical oxygen sensor (2000)

Conference Abstract| February 01 2000 Cell viability screening method using optical oxygen sensor Tomas O'Riordan; Tomas O'Riordan 1Biochemistry Department, National University of Ireland, Cork Search for other works by this author on: This Site PubMed Google Scholar Deirdre Buckley; Deirdre Buckley 1Biochemistry Department, National University of Ireland, Cork Search for other works by this author on: This Site PubMed Google Scholar Rosemary O'Connor; Rosemary O'Connor 1Biochemistry Department, National University of Ireland, Cork Search for other works by this author on: This Site PubMed Google Scholar Dmitri Papkovsky Dmitri Papkovsky 1Biochemistry Department, National University of Ireland, Cork Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (1): A43. https://doi.org/10.1042/bst028a043b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Tomas O'Riordan, Deirdre Buckley, Rosemary O'Connor, Dmitri Papkovsky; Cell viability screening method using optical oxygen sensor. Biochem Soc Trans 1 February 2000; 28 (1): A43. doi: https://doi.org/10.1042/bst028a043b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
PO187 Parkinson’s families project recruiting via the bnsu: baseline data (2017)

<h3>Background</h3> Parkinson’s disease (PD) is associated with motor and non-motor symptoms, including cognitive impairment. Genetic features may influence clinical symptoms. <h3>Objective</h3> Familial PD patients have been recruited through the ABN British Neurological Surveillance Unit (BNSU) to the Parkinson’s Families Project. A primary aim of this study is to examine how genetic factors influence phenotype. We present baseline clinical data and a description of cognitive impairment in familial PD patients from this cohort. <h3>Methods</h3> Eligible patients are referred through the BNSU. Blood samples are collected for DNA. Systematic clinical data is collected using a similar approach to the Tracking Parkinson’s (PRoBaND) study. <h3>Results</h3> 101 patients with familial PD have been recruited to date from participating hospitals or remotely. Cognitive outcomes were assessed in the Montreal Cognitive Assessment (MoCA). In the first 85 familial PD patients, 27.1% of patients met criteria for mild cognitive impairment, 10.6% patients met criteria for severe cognitive impairment, and 62.4% of patients had normal cognition. Analysis of genetic data is underway and results with rare Mendelian mutations will be reported. <h3>Conclusions</h3> The BNSU is an essential source of recruitment to the Parkinson’s Families Project. Identification of genetic factors that influence phenotype will lead to new drug targets.
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO (2012)

AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In addition to its role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which leads to DNA damage and increased mutation frequency. Although this latter function may promote leukemogenesis, concurrent p53 activation also leads to an increased baseline apoptotic rate. It is unclear how AE expression is able to counterbalance this intrinsic apoptotic conditioning by p53 to promote survival and self-renewal. In this report, we show that Bcl-xL is up-regulated in AE cells and plays an essential role in their survival and self-renewal. Further investigation revealed that Bcl-xL expression is regulated by thrombopoietin (THPO)/MPL-signaling induced by AE expression. THPO/MPL-signaling also controls cell cycle reentry and mediates AE-induced self-renewal. Analysis of primary AML patient samples revealed a correlation between MPL and Bcl-xL expression specifically in t(8;21) blasts. Taken together, we propose that survival signaling through Bcl-xL is a critical and intrinsic component of a broader self-renewal signaling pathway downstream of AML1-ETO-induced MPL.
Fibronectin Is Overproduced by Keloid Fibroblasts during Abnormal Wound Healing (1989)

Wound healing in certain individuals leads to the development of keloid tumors which exhibit abnormal collagen metabolism and an increased abundance of extracellular matrix components. Comparison of fibronectin levels in fibroblasts derived from keloids and normal dermis revealed a relative increase in intracellular and extracellular fibronectin in the keloid-derived cells. While fibronectin was similarly processed, compartmentalized, and degraded by both cell types, fibronectin biosynthesis was found to be accelerated as much as fourfold in keloid fibroblasts due to a corresponding increase in the amount of accumulated fibronectin mRNA. These changes account for the elevated steady-state level of the molecule in keloid fibroblasts and suggest that increased fibronectin in keloid lesions is due to overproduction by the wound-healing fibroblasts. Glucocorticoid treatment stimulated fibronectin biosynthesis in both normal and keloid fibroblasts. However, the amount of stimulation was less for the keloid-derived cells, indicating a limitation on maximal rates of fibronectin biosynthesis. These observations suggest that separate mechanisms act to control basal and maximal rates of fibronectin production. Biosynthesis of the 140-kilodalton fibronectin receptor was also found to be increased in keloid fibroblasts, suggesting some level of coordinate regulation for fibronectin and fibronectin receptor expression.
Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat*1 (2004)

Thus, myocardial ischemia induced by left coronary artery ligation resulted in a sustained increase in Ang-2 expression and a reciprocal decrease in Ang-1, consistent with a predominant role for Ang-2 in the angiogenic response to MI.
Dynamic Migration Strategy for Mobile Multi-Access Edge Computing Services (2022)

The concept of Internet-of-Vehicles (IoV) has emerged to support the future Intelligent Transportation System (ITS). As an enabling technology for the IoV, Multi-access Edge Computing (MEC) provides cloud computing capabilities at the edge of the radio access network and supports vehicular task offloading of low-latency services. However, vehicles move across radio cells and, computing services offloaded to the Mobile Edge Hosts (MEH)s might be interrupted. The key to ensuring service continuity is to preemptively anticipate the service migration process to a well-identified subset of available MEHs, at the optimal time. In this paper, we develop a new algorithm that combines the exponential-weight algorithm for exploration and exploitation (EXP3) and the Lyapunov optimization to jointly and proactively decide when to trigger migration and where to migrate the service before the handover. Our algorithm leads to significant cost saving while meeting any given risk and availability targets which are new metrics introduced to assess service continuity.
Measurement and modeling of stimulus-evoked electromyography in lengthened and shortened muscles for spinal cord injured subjects during an electrically-elicited fatigue process (2006)

This study compares the amplitude and temporal features of stimulus-evoked electromyography (EMG) of paralyzed muscle, rectus femoris (RF), in both lengthened and shortened positions of six spinal cord injured (SCI) subjects during an electrically elicited fatigue process. The torque output and evoked EMG were fitted by hyperbolic tangent functions from which their amplitude residual levels and temporal inflection times can be extracted. Furthermore, a structural EMG model of Fuglevand et al (1992 Biol. Cybern. 67 143-53) was modified to include type I (slow twitch) and type II (fast twitch) of motor unit (MU) fibers with viable parameters obtained from paralyzed muscles to observe their amplitude and temporal changes. Our results showed that the amplitude of stimulus-evoked EMG decreased earlier in the lengthened muscle with a shorter inflection time (48.53 +/- 8.7 s versus 55.13 +/- 4.03 s) than that of the shortened position during 120 s of stimulation time (p < 0.05). Similarly, the peak-to-peak duration (PTPd) of the evoked EMG increased faster at an earlier time to a higher asymptotical value in lengthened muscle (2.23 +/- 0.74 versus 1.77 +/- 0.54), compared to that of a shortened one (p < 0.05). These observations coincided with the higher rising rate and larger final value of the temporal coefficients, i.e., longer duration, in both type I and II MUs of lengthened muscles. From the observation of all parameters, the fatigue process in lengthened muscle proceeds faster than that in shortened muscle.
IndividualEscherichia coli cells studied from light scattering with the scanning flow cytometer (2000)

The indicatrices of E. coli were reproducible and could be used for identification of these cells in biologic suspensions. The angular location of the indicatrix minimum can be used in separation of cells in logarithmic and stationary phases. To use effectively the indicatrices for that purpose, the light-scattering properties of other microorganisms have to be studied.
Selecting appropriate tremor patients for DBS (2009)

Introduction - Patient-related factors - Tremor-related factors - Clinical and instrumental assessments of tremor - Surgical planning
Toward Green Media Delivery: Location-Aware Opportunities and Approaches (2014)

Mobile media has undoubtedly become the predominant source of traffic in wireless networks. The result is not only congestion and poor Quality-of-Experience, but also an unprecedented energy drain at both the network and user devices. In order to sustain this continued growth, novel disruptive paradigms of media delivery are urgently needed. We envision that two key contemporary advancements can be leveraged to develop greener media delivery platforms: 1) the proliferation of navigation hardware and software in mobile devices has created an era of location-awareness, where both the current and future user locations can be predicted; and 2) the rise of context-aware network architectures and self-organizing functionalities is enabling context signaling and in-network adaptation. With these developments in mind, this article investigates the opportunities of exploiting location-awareness to enable green end-to-end media delivery. In particular, we discuss and propose approaches for location-based adaptive video quality planning, in-network caching, content prefetching, and long-term radio resource management. To provide insights on the energy savings, we then present a cross-layer framework that jointly optimizes resource allocation and multi-user video quality using location predictions. Finally, we highlight some of the future research directions for location-aware media delivery in the conclusion.
Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops. (1992)

Existing data suggest that the human keratin 10 intermediate filament protein is polymorphic in amino acid sequence and in size. To precisely define the nature of the polymorphism, we have used PCR amplification and sequence analyses on DNA from several individuals including five with documented size variations of the keratin 10 protein. We found no variation in the N-terminal or rod domain sequences. However, we observed many variations in the V2 subdomain near the C terminus in glycine-rich sequences with a variation of as much as 114 base pairs (38 amino acids), but all individuals had either one or two variants. Our results show that (i) the keratin 10 system is far more polymorphic than previously realized, (ii) the polymorphism is restricted to insertions and deletions of the glycine-rich quasipeptide repeats that form the glycine-loop motif in the C-terminal domain, (iii) the polymorphism can be accounted for by simple allelic variations that segregate by normal Mendelian mechanisms, and (iv) the differently sized PCR products most likely represent different alleles of a single-copy gene per haploid genome.
Small-signal Approximations of Frequency Estimation Algorithms (2022)

Estimates of power system frequency are beginning to be used in critical, real-time applications such as synthetic inertia. The behavior of the algorithms used to estimate frequency from point-on-wave signals can be complicated, and algorithm tuning difficult for non-experts. In this paper, small-signal approximations for four common frequency estimation algorithms are presented. These approximations are demonstrated to be both theoretically and empirically sound. They are valuable for three primary reasons: 1) they reduce the level of technical expertise required for effective tuning; 2) they effectively capture the dynamics of the algorithm so can be used as a proxy for the algorithm itself in the analysis of feedback control loops that employ frequency feedback; and 3) they can easily be implemented in transient stability simulation software in order to represent realistic frequency estimation.
The Threadwire Saw (1996)

†Department of Orthopaedic Surgery, School of Medicine, Kanazawa University. 13-1, Takaramachi, Kanazawa 920, Japan. E-mail address: [email protected]
Live‐Cell Super‐Resolution Imaging Goes Multicolor (2012)

New resolutions: The combined use of photoactivatable fluorescent proteins and synthetic fluorophores considerably expands our options for multicolor super-resolution fluorescence imaging and enables for the first time the simultaneous imaging of more than two proteins with subdiffraction optical resolution in living cells.
Outbreaks of E coli (1997)

Verotoxin producing Escherichia coli causes severe gastrointestinal disease, often with frank blood in the stool (haemorrhagic colitis). In about 2-7% of cases infection is complicated by haemolytic uraemic syndrome,1 which has a mortality of 3-5%. The current outbreak of infection with E coli 0157 in Scotland,2 described as “the second largest recorded outbreak anywhere,” is the subject of an interim report by Professor Hugh Pennington's expert group, produced with commendable speed.

Perhaps inevitably, the group has been able to discharge some parts of its remit better than others. With various legal proceedings pending, the first part of its remit—to examine the specific “circumstances which led to the outbreak”—receives only a brief reference. There are no descriptive or other data. Regarding the second part of its remit—“the implications for food safety and …
Structural Changes of the Prion Protein in Lipid Membranes Leading to Aggregation and Fibrillization (2003)

Prion diseases are associated with a major refolding event of the normal cellular prion protein, PrP(C), where the predominantly alpha-helical and random coil structure of PrP(C) is converted into a beta-sheet-rich aggregated form, PrP(Sc). Under normal physiological conditions PrP(C) is attached to the outer leaflet of the plasma membrane via a GPI anchor, and it is plausible that an interaction between PrP and lipid membranes could be involved in the conversion of PrP(C) into PrP(Sc). Recombinant PrP can be refolded into an alpha-helical structure, designated alpha-PrP isoform, or into beta-sheet-rich states, designated beta-PrP isoform. The current study investigates the binding of beta-PrP to model lipid membranes and compares the structural changes in alpha- and beta-PrP induced upon membrane binding. beta-PrP binds to negatively charged POPG membranes and to raft membranes composed of DPPC, cholesterol, and sphingomyelin. Binding of beta-PrP to raft membranes results in substantial unfolding of beta-PrP. This membrane-associated largely unfolded state of PrP is slowly converted into fibrils. In contrast, beta-PrP and alpha-PrP gain structure with POPG membranes, which instead leads to amorphous aggregates. Furthermore, binding of beta-PrP to POPG has a disruptive effect on the integrity of the lipid bilayer, leading to total release of vesicle contents, whereas raft vesicles are not destabilized upon binding of beta-PrP.
Efficacy and safety of cimicoxib in the control of perioperative pain in dogs (2013)

Cimicoxib had non-inferior efficacy and tolerability when compared to carprofen for the control of perioperative pain in dogs undergoing orthopaedic or soft tissue surgery.
Stereoscopic image quality assessment via convolutional neural networks (2017)

This paper mainly introduces an image quality assessment for stereoscopic images via Convolutional Neural Networks (CNN). Firstly, the left and the right view images of a stereoscopic image need to be fused in the way of Principal Component Analysis (PCA). Secondly, method of Mean Subtraction and Contrast Normalization (MSCN) is applied in the fusion images. Finally, taking non-overlapping small patches of each image as the input, the CNN can train an evaluation model between image features and Different Mean Opinion Scores (DMOS). The model can predict quality scores of image patches and we average the patch scores of each image to get the final predicted quality scores of large images.