gebhart/patrepeval huggingface dataset:
Device design requirements for MOS analog circuits (1987)

A hierarchical framework is presented for evaluating the impact of various device design parameters on the performance of MOS circuits. Various circuit classifications and the circuit parameters that are most important for that particular application are defined. As an example, the optimization of the design for analog circuits is considered, addressing the circuit performance parameters of gain, bandwidth, signal swing, and noise.
Regioselectivity and Network Structure of Difunctional Alkyl-Substituted Aromatic Amine-Based Polybenzoxazines (2000)

The regioselectivity of the benzoxazine polymerization in aromatic amine-based polybenzoxazines is investigated through systematic manipulation of the monomer chemistry. The network structures of the cured materials are elucidated by FTIR and GC/MS. Selectively protecting or activating sites on the pendant aromatic ring toward electrophilic aromatic substitution with alkyl groups allows a series of materials to be developed which contain a varying amount of phenolic Mannich bridges, arylamine Mannich bridges, and methylene linkages. Activation of sites on the pendant rings by methyl substituent groups lowers the peak exotherm temperature by up to 45 °C. Temperature-modulated differential scanning calorimetry shows that in some of these materials the development of the glass transition temperature exceeds that of the curing temperature.
β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment (2019)

Heterodimeric integrin receptors control cell adhesion, migration and extracellular matrix assembly. While the α integrin subunit determines extracellular ligand specificity, the β integrin chain binds to an acidic residue of the ligand, and cytoplasmic adapter protein families such as talins, kindlins and paxillin, to form mechanosensing cell matrix adhesions. Alternative splicing of the β1 integrin cytoplasmic tail creates ubiquitously expressed β1A, and the heart and skeletal muscle-specific β1D form. To study the physiological difference between these forms, we developed fluorescent β1 integrins and analyzed their dynamics, localization, and cytoplasmic adapter recruitment and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP-β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP-β1A integrin was sensitive to C-terminal tail mutagenesis, GFP-β1D integrin was recruited independently of the distal NPXY motif. In addition, a P786A mutation in the proximal, talin-binding NPXY<sup>783</sup> motif switched β1D to a highly dynamic integrin. In contrast, the inverse A786P mutation in β1A integrin interfered with paxillin recruitment and proliferation. Thus, differential β1 integrin splicing controls integrin-dependent adhesion signaling, to adapt to the specific physiological needs of differentiated muscle cells.
Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin (2018)

MDCK dog kidney epithelial cells express two isoforms of nonmuscle myosin heavy chain II, IIA and IIB. Using the CRISPR/Cas9 system, we established cells in which the IIA gene was ablated. These cells were then transfected with a vector that expresses GFP-IIA chimeric molecule under the control of a tetracycline-responsible element. In the absence of Dox (doxycyclin), when GFP-IIA is expressed (GFP-IIA+), the cells exhibit epithelial cell morphology, but in the presence of Dox, when expression of GFP-IIA is repressed (GFP-IIA-), the cells lose epithelial morphology and strong cell-cell adhesion. Consistent with these observations, GFP-IIA- cells failed to assemble junction components such as E-cadherin, desmoplakin, and occludin at cell-cell contact sites. Therefore, IIA is required for assembly of junction complexes. MDCK cells with an ablation of the α-catenin gene also exhibited the same phenotype. However, when in GFP-IIA- cells expressed α-catenin lacking the inhibitory region or E-cadherin/α-catenin chimeras, the cells acquired the ability to establish the junction complex. These experiments reveal that IIA acts as an activator of α-catenin in junction assembly.
Optimization of Bypass Outlet Guide Vane for Low Interaction Noise (2014)

An optimization approach has been developed and applied to a fan stage representative of a modern turbofan engine to achieve novel, realistic, low-interaction-tone noise bypass outlet guide vanes with acceptable mechanical and aerodynamic properties. The incorporation of axial sweep in the design of the bypass stators is used as a passive method to achieve sizeable reductions in the discrete frequency tones generated by the impingement of the fan wakes. The acoustic benefits, mechanical properties, and aerodynamic performance of an unconventional sweep profile of the stator leading edge have been investigated numerically in an optimization framework using a combination of computational fluid dynamics and finite-element methods to solve each part of the problem. The results obtained in two separate optimizations to reduce interaction noise at the noise-critical sideline operating condition are presented and analyzed.
Liquid Metal Embrittlement in Resistance Spot Welding (Fourth Report) (2020)

This paper describes the development of the finite element (FE) analysis system for comprehensive evaluation of the phenomena occurring during resistance spot welding. The framework underlying this system is FE calculation based on an incrementally coupled electrical-thermal-mechanical simulation procedure. In recent years, evaluation of stress in the spot welding process has been important for elucidating the mechanism of liquid metal embrittlement (LME) crack formation. This analytic system is applied to evaluating the influence of clearance between steel sheets and electrodes on residual stress in the spot welded zone.
Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 (2005)

Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequently have unacceptably low oral bioavailabilities. We now report that water-solubility can be achieved by inserting an amino functionality in the N(9) side chain. This results in compounds that are potent, soluble in aqueous media, and orally bioavailable. In an HER-2 degradation assay, the highest potency was achieved with the neopentylamine 42 (HER-2 IC(50) = 90 nM). In a murine tumor xenograft model (using the gastric cancer cell line N87), the H(3)PO(4) salts of the amines 38, 39, and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day. The amines 38, 39, and 42 are the first Hsp90 inhibitors shown to inhibit tumor growth upon oral dosage.
High prevalence of right ventricular systolic dysfunction in early systemic sclerosis. (2004)

Reduced RVEF appears to be a common feature in early SSc; it may be due to intrinsic myocardial involvement and is acutely improved by nicardipine.
Effect of Headgroup Chirality in Nanoassemblies. Part 1. Self-Assembly of d-Isoascorbic Acid Derivatives in Water (2009)

L-(+)-Ascorbic acid and D-(-)-isoascorbic acid are epimers, with an opposite configuration at the C5 stereogenic chiral center. Single-chained surfactants that carry a L-ascorbic or d-isoascorbic acid residue as hydrophilic headgroup and an alkanoate tail as hydrophobic chain were synthesized. We refer to these as L-ASCn and D-ASCn, with n=8, 10, or 12. The role of the headgroup configuration in determining the nature of both the pure compounds and their nano assembly in aqueous dispersions were studied. Surface tension, infrared spectroscopy, differential scanning calorimetry, conductivity, small-angle X-ray scattering, and wide-angle X-ray diffractometry were used to characterize surfactant properties as a function of temperature and concentration. The L and D headgroup forms have significantly different hydration. This greatly affects the structure and stability of the aggregates in the micellar and coagel states.
Comprehensive defect-detection method for a small-sized curved optical lens (2019)

During quality-assurance procedures in the mass production of small-sized curved optical lenses, fine defects are usually detected via manual observation, which is not recommended owing to the associated drawbacks of high error rate, low efficiency, and nonamenability to quantitative analysis. To address this concern, this paper presents a comprehensive defect-detection system based on transmitted fringe deflectometry, dark-field illumination, and light transmission. Experimental results obtained in this study reveal that the proposed method demonstrates efficient and accurate detection of several microdefects occurring in small-sized optical lenses, thereby providing valuable insights into the optimization of parameters concerning the mass production of optical lenses. The proposed system can be applied to the actual mass production of small-sized curved optical lenses.
Guest Editors' Introduction: Overview of Sensor Networks (2004)

Wireless sensor networks could advance many scientific pursuits while providing a vehicle for enhancing various forms of productivity, including manufacturing, agriculture, construction, and transportation.
Designing and Injecting a Chemical Formulation for a Successful Off-Shore Chemical EOR Pilot in a High-Temperature, High-Salinity, Low-Permeability Carbonate Field (2016)

Abstract This article describes the formulation design, optimization, implementation, and lessons learned leading up to a successful 1-spot surfactant-polymer (SP) pilot in the Middle East. The target field is a high-temperature, high-salinity, low-permeability carbonate, and thus presents both great challenges and great potential for the application of chemical EOR technology. A surfactant-polymer (SP) formulation was optimized for these conditions based upon a novel, hydrophilicity-enhanced molecule for high-temperature, high-salinity reservoirs synthesized by Total R&amp;D labs. Thermal stability tests, over 5000 microemulsion pipette tests, and more than 40 corefloods were performed during the screening and optimization process leading up to the 1-spot SP pilot. Additionally, a novel method was developed to optimize polymer molecular weight distribution, in order to decouple in-situ viscosity from near-wellbore injectivity. The final formulation consists of a 0.4 pore volume (PV) SP slug of 1.35% active surfactant, plus 1% clarifier, and SAV-225 polymer (SNF Floerger) in a 80 g/l brine corresponding to a hypothetical softened mixture of seawater and local aquifer water. This is followed by a polymer drive of AN-125 polymer (SNF Floerger) in softened seawater, such that a negative salinity gradient is imposed between the 230 g/l formation brine, 80 g/l SP slug, and 42 g/l seawater. The formulation was designed and implemented without need for a preflush. Residual oil saturation to chemicals (Sorc) in analog limestone cores was measured as 5%±2%, corresponding to a recovery factor (RF) of 90%±4%. Reservoir limestone contains significant heterogeneity on the core-scale, likely preventing the formation of an oil bank, and thus yielded lower recoveries (Sorc: 13%±2%, RF: 84%±4%). One-spot pilot recovery corresponded closely to recovery in analog cores (Sorc: 4%, RF = 90%, Al-Amrie et al., 2015), suggesting that the reason for the lower recovery in reservoir cores was in fact due to the short core length with respect to the mixing zone, as suggested in a previous publication (Levitt et al., 2012).
Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. (1983)

Topical 2% l- or d-timolol reduced the elevation of intraocular pressure induced by water-loading in conscious rabbits. This drug effect appeared on the peak elevation (in pigmented eyes) and on the down-phase (in albino and pigmented eyes) of elevated intraocular pressure. The contralateral eye and the treated eye responded similarly. In urethane anesthetized, water-loaded rabbits, a greater inhibitory effect of l-timolol was observed in pigmented eyes than in albino eyes. Two per cent l-timolol caused alterations of heart rate and arterial blood pressure in water-loaded anesthetized rabbits, but time courses of these alterations did not correlate with the inhibitory effect on the elevation of intraocular pressure. The beta-adrenergic antagonistic activity of l-timolol and d-timolol were compared by their ability to inhibit l-isoproterenol-stimulated cyclic AMP synthesis in the rabbit iris-ciliary body preparation in vitro. The I50S for l- and d-timolol differ by about 1.5 log units. In our studies, d-timolol has little of the intraocular pressure lowering and the beta-adrenergic antagonistic activity of l-timolol. Thus, the conscious, water-loaded, pigmented rabbit can be used as a model for studying the effects of beta-adrenergic antagonists on intraocular pressure.
Slow light and band gaps in metallodielectric cylinder arrays (2009)

We consider two-dimensional three-component photonic crystals wherein one component is modeled as a drude-dispersive metal. It is found that the dispersion relation of light in this environment depends critically on the configuration of the metallic and dielectric components. In particular, for the case of an incident electromagnetic wave with electric field vector parallel to the axis of the cylinders it is shown that the presence of dielectric shells covering the metallic cylinders leads to a closing of the structural band gap with increased filling factor, as would be expected for a purely dielectric photonic crystal. For the same polarization, the photonic band structure of an array of metallic shell cylinders with dielectric cores do not show the closing of the structural band gap with increased filling factor of the metallic component. In this geometry, the photonic band structure contains bands with very small values of group velocity with some bands having a maximum of group velocity as small as .05c.
Operation and maintenance (2021)

Abstract This chapter first provides information on general health and safety rules to be applied by operators in monitoring urban drainage and stormwater management (UDSM) systems, especially in the harsh confined environment of underground sewer systems. Second, it presents experience-based key recommendations for best practice and quality in operation, management and maintenance of sensors and installations for rainfall and discharge measurements. In the last part, three numerical methods (ordinary least squares, Williamson least squares, non-linear regression) are presented, with detailed examples of application, to establish calibration functions which are necessary for all sensors used in UDSM monitoring.
Programmable Motion and Separation of Single Magnetic Particles on Patterned Magnetic Surfaces (2005)

Motion of single micrometer-sized magnetic particles on patterned magnetic surfaces is controlled by a rotating magnetic field (see Figure and cover). Patterns of thin-film magnetic elements are tailored to form transport lines. Individual particles are separated by adding junctions to the transport lines. The method can improve existing applications in biotechnology and generate new ones in life sciences.
Development of a microwave calorimeter for simultaneous thermal analysis, infrared spectroscopy and dielectric measurements (2004)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Adapting Construction Staking to Modern Technology (2017)

This report summarizes the tasks and findings of the ICT Project R27-163, Adapting Construction Staking to Modern Technology, which aims to develop written procedures for the use of modern technologies (such as GPS and civil information modeling) in construction staking of highway projects, for inclusion in the Illinois Department of Transportation’s (IDOT’s) Construction Manual. Six primary research tasks were completed: (1) conducting a comprehensive literature review on the use of modern technologies in construction staking by state departments of transportation (DOTs) and contractors; (2) conducting a survey to gather information from state DOTs and contractors on current practices employed by other states; (3) identifying a set of potential practices for employment in Illinois; (4) conducting a survey to gather feedback from IDOT staff and Illinois contractors; (5) developing draft summarized written procedures for review by the Technical Review Panel (TRP); and (6) developing complete written procedures for the use of modern technologies in construction staking of highway projects, for inclusion in IDOT’s Construction Manual. The written procedures are intended to support construction-staking processes when a contractor employs such technologies. The procedures are expected to enable the employment of these technologies in Illinois and, in turn, to offer major opportunities for quality improvements, cost savings, and expediting project delivery.
Financial deepening in sub-Saharan Africa : theory and innovations (1992)

The three papers in this volume relate to different aspects of the problem of developing the financial system in low-income countries so that it is better able to facilitate widespread mobilization of financial resources, investment, trade, and risk-taking. While these papers focus on sub - Saharan Africa, their analysis is relevant to any low-income country with a relatively underdeveloped financial system. The papers are concerned with financial deepening not only in the sense of raising the ratio of monetary aggregates to gross national product, but also in the sense of improving access to financial services through out the economy and increasing the linkages between formal and informal segments. They are intended for both policy analysts and practioners. Two principal themes run through these papers and are especially relevant in the African context. First, the importance of overcoming fragmentation in which different segments and units of the financial systems have little interaction with each other and funds and clients cannot move easily between them. Second, the dilemma of increasing access to financial services for small-scale enterprises (SSEs), which appear to be both underserved and underrepresented compared to fast-growing Asian countries and to what would be expected in a less constrained economic environment.
Ultimate Bearing Capacity Assessment of Hull Girder With Asymmetric Cross Section (2018)

The objective of this study is to investigate the variation of neutral axis of ship hull girder due to asymmetric geometry or asymmetric load, and its influence on the ultimate strength (ULS) of hull girder. In order to account for asymmetric geometries and loads of hull girders, the force equilibrium and force-vector equilibrium criteria together with a minimum convergence factors (error) method are employed to determine the translation and rotation of neutral axis plane (NAP) of symmetric or asymmetric hull cross section in the application of Smith's method at each step of curvature of the hull girder. The ULSs of Dow's 1/3 frigate model with three predefined structural integrity states, one intact and two damaged, respectively, is investigated by the improved Smith's method (ISM) for a range of variation of heeling angles. The influence of asymmetric geometry and load on the motion of NAP and on the ULS are analyzed and discussed. The results show that the improved iteration strategy together with the minimum convergence factors (error) method is efficient and more accurate in searching the translation and rotation of NAP. Finally, the envelope curves of the bending moments in the three predefined integrity states are obtained, which can be used for assessing ULS of hull girders under combined vertical and horizontal wave bending moments.
In Vitro Induction of the Expression of Multiple IgA Isotype Genes in Rabbit B Cells by TGF-β and IL-2 (1999)

Abstract The rabbit genome has 13 different Cα genes that are expressed at different levels in mucosal tissues. To analyze the factors involved in the differential expression of these Cα genes, we cloned and sequenced the promoters of the Iα regions that control the expression of sterile mRNA. We found that all Cα genes, including Cα3 and Cα8, which are not expressed, and Cα4, which is expressed at high levels, have similar nucleotide sequences in the Iα region, and all contain the recognition elements for TGF-β in the promoter. B lymphocytes from popliteal lymph nodes or Peyer’s patch activated in vitro could be induced by TGF-β to express sterile IgA transcripts of all IgA isotypes, except Cα2, Cα3, and Cα8. Many single B lymphocytes transcribed sterile mRNA of more than one IgA isotype, which demonstrates that transcription of sterile mRNA alone does not regulate the IgA isotype switch. The addition of IL-2 led to the expression of transcripts of mature IgA of all isotypes, except Cα2, Cα3, and Cα8. The predominantly expressed isotype in these experiments was Cα4. With the use of an IgA4-specific mAb we found that IgA4+ plasma cells are unevenly distributed throughout the small intestine such that many of the IgA+ plasma cells in the duodenum-jejunum produced IgA4, whereas in the lower part of the ileum IgA4-producing cells were almost absent. Because the microbial flora varies throughout the intestine, we suggest that the microbial flora creates different local environments and thus affects either isotype switching or homing of IgA-expressing cells.
Exome and transcriptome sequencing identifies loss of <em>PDLIM2</em> in metastatic colorectal cancers (2017)

Taken together, our findings uncovered various genomic alterations potentially leading to metastasis in CRC and provide important insights into the development of potential therapeutic targets for preventing metastatic progression of CRC.
Physical characterization of carbonaceous products from fire and fire retardants:assessment of the impact on fire performance (2017)

International audience
Extending Bayesian RFS SLAM to multi-vehicle SLAM (2012)

In this paper we present a novel solution to the Multi-Vehicle SLAM (MVSLAM) problem by extending the random finite set (RFS) based SLAM filter framework using two recently developed multi-sensor information fusion approaches. Our solution is based on the modelling of the measurements and the landmark map as RFSs and factorizing the MVSLAM posterior into a product of the joint vehicle trajectories posterior and the landmark map posterior conditioned the vehicle trajectories. The joint vehicle trajectories posterior is propagated using a particle filter while the landmark map posterior conditioned on the vehicle trajectories is propagated using a Gaussian Mixture (GM) implementation of the probability hypothesis density (PHD) filter.
Observation of Regenerated Fungiform Taste Buds After Severing the Chorda Tympani Nerve Using Confocal Laser Scanning Microscopy In vivo (2014)

Regenerated fungiform taste bud could be observed in vivo using confocal laser scanning microscopy, indicating that regenerated taste bud can be detected without biopsy.