gebhart/patrepeval huggingface dataset:
1571. In Vitro Activity of Ceftazidime-Avibactam and Comparator Agents Against MDR Enterobacterales and Pseudomonas aeruginosa Collected in Latin America During the ATLAS Global Surveillance Program 2017-2018 (2020)

Abstract Background Ceftazidime-avibactam (CAZ-AVI) is a β-lactam/non-β-lactam β-lactamase inhibitor combination that can inhibit class A, C and some class D β-lactamases. Resistance caused by these β-lactamases often results in multidrug-resistance (MDR). This study evaluated the in vitro activity of CAZ-AVI and comparators against MDR Enterobacterales and Pseudomonas aeruginosa isolates collected from patients in Latin America. Methods Non-duplicate clinical isolates were collected in 2017-2018 in 10 countries in Latin America. Susceptibility testing was performed using CLSI broth microdilution and interpreted using CLSI 2020 and FDA (tigecycline) breakpoints. MDR was defined as resistant (R) to ≥3 of 7 sentinel drugs: amikacin (AMK), aztreonam (ATM), cefepime (FEP), colistin (CST), levofloxacin (LVX), meropenem (MEM), and piperacillin-tazobactam (TZP). Results The activity of CAZ-AVI and comparators against all isolates and MDR subsets is shown in the table. MDR rates for the studied species ranged from 17.6% among E. cloacae to 31.0% among K. pneumoniae. CAZ-AVI was active against 99% of Enterobacterales isolates and maintained activity against 85-99% of MDR isolates of the examined species. Only tigecycline showed comparable or higher activity. Among P. aeruginosa, CAZ-AVI was active against 86% of all isolates and 45% of MDR isolates; no other studied drug was more active. The three most common MDR phenotypes among Enterobacterales were 1) R to ATM, FEP, and LVX (n=538, 50% of all MDR Enterobacterales; 100% susceptible (S) to CAZ-AVI), 2) R to all sentinel drugs except AMK and CST (n=112, 10% of all MDR isolates; 88% S to CAZ-AVI), and 3) R to ATM, FEP, LVX, and TZP (n=111, 10% of all MDR Enterobacterales; 100% S to CAZ-AVI). The three most common MDR phenotypes among P. aeruginosa were 1) R to all sentinel drugs except CST (n=70, 22% of all MDR isolates; 20% S to CAZ-AVI), 2) R to AMK, LVX, and MEM (n=33, 10% of all MDR isolates; 33% S to CAZ-AVI), and 3) R to all sentinel drugs except AMK and CST (n=30, 9% of all MDR isolates; 70% S to CAZ-AVI). Table Conclusion These in vitro data suggest that CAZ-AVI can be an effective treatment option for infections caused by MDR Enterobacterales and P. aeruginosa collected in Latin America. Disclosures Krystyna Kazmierczak, PhD, IHMA (Employee)Pfizer, Inc. (Consultant) Sibylle Lob, PhD, IHMA (Employee)Pfizer, Inc. (Consultant) Greg Stone, PhD, AztraZeneca (Shareholder, Former Employee)Pfizer, Inc. (Employee) Daniel F. Sahm, PhD, IHMA (Employee)Pfizer, Inc. (Consultant)Shionogi &amp; Co., Ltd. (Independent Contractor)
Phase Noise Influence on Radar Signal Focusing and SAR Tomography (2019)

International audience
Plasmon-Activated Water Reduces Amyloid Burden and ImprovesMemory in Animals with Alzheimer’s Disease (2019)

With the great extension of the human lifespan in recent times, many aging diseases have inevitably followed. Dementia is one of the most-commom neurodegenerative aging diseases, in which inflammation-related Alzheimer's disease (AD) is the most prevalent cause of dementia. Amyloid accumulation in the brain, which occurs before any clinical presentations, might be the first and key step in the development of AD. However, many clinical trials have attempted to remove amyloid from brains of AD patients, but none has so far been successful. Negatively charged plasmon-activated water (PAW) is created by resonantly illuminated gold (Au) nanoparticles (NPs), which reduce the hydrogen-bonded (HB) structure of water. PAW was found to possess anti-oxidative and anti-inflammatory effects. Herein, we report on an innovative strategy to retard the progression of AD by the daily consumption of PAW instead of normal deionized (DI) water. APPswe/PS1dE9 transgenic mice were treated with PAW or DI water from the age of 5 months for the next 9 months. Encouragingly, compared to DI water-treated mice, mice treated with PAW presented better memory performance on a test of novel object recognition and had a significantly lower amyloid burden according to 18F-florbetapir amyloid-PET and phosphorylated (p)-tau burden according to Western blotting and immunohistochemistry measurements. There were no obvious side effects in PAW-treated mice. Collectively, our findings support that PAW was able to reduce the amyloid and p-tau burden and improve memory in an AD mouse model. However, the protein levels of molecules involved in amyloid metabolism and oligomeric amyloid did not change. We propose that the effects of PAW of reducing the amyloid burden and improving memory function cannot be attributed to synthesis/degradation of amyloid-βprotein but probably in preventing aggregation of amyloid-β proteins or other mechanisms, including anti-inflammation. Further applications of PAW in clinical trials to prevent the progression of AD are being designed.
Soil Enzyme Activities as an Integral Part of the Environmental Risk Assessment of Nanopesticides (2020)

Sem resumo
Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling (1999)

To study constitutive Janus kinase signaling, chimeric proteins were generated between the pointed domain of the ets transcription factor TEL and the cytosolic tyrosine kinase Jak2. The effects of these proteins on interleukin-3 (IL-3)-dependent proliferation of the hematopoietic cell line, Ba/F3, were studied. Fusion of TEL to the functional kinase (JH1) domain of Jak2 resulted in conversion of Ba/F3 cells to factor-independence. Importantly, fusion of TEL to the Jak2 pseudokinase (JH2) domain or a kinase-inactive Jak2 JH1 domain had no effect on IL-3-dependent proliferation of Ba/F3 cells. Active TEL-Jak2 constructs (consisting of either Jak2 JH1 or Jak2 JH2+JH1 domain fusions) were constitutively tyrosine-phosphorylated but did not affect phosphorylation of endogeneous Jak1, Jak2, or Jak3. TEL-Jak2 activation resulted in the constitutive tyrosine phosphorylation of Stat1, Stat3, and Stat5 as determined by detection of phosphorylation using activation-specific antibodies and by binding of each protein to a preferential GAS sequence in electrophoretic mobility shift assays. Elucidation of signaling events downstream of TEL-Jak2 activation may provide insight into the mechanism of leukemogenesis mediated by this oncogenic fusion protein.
ChemInform Abstract: Improved Method for Bisallylation of cis‐Bicyclo(3.3.0)octane‐3,7‐ dione via the Claisen Rearrangement. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in Parkinson’s Disease? (2014)

Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has separate items for measuring sleep problems (item 1.7) and daytime sleepiness (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the PD Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 PD patients were enrolled. Spearman's rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lin's Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the "disturbed sleep" domain of PDSS-2 showed high correlation with "sleep problems" item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with "daytime sleepiness" item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both sleep problems and daytime sleepiness and identifies subjects whose disabilities need further investigation.
Sudden Cardiac Arrest in Athletic Medicine. (2001)

OBJECTIVE: To emphasize the importance of decreasing the response time by a trained target responder to increase the survival rate among athletes experiencing sudden cardiac arrest at an athletic event. BACKGROUND: Death due to sudden cardiac arrest that is witnessed is preventable in many cases. However, most people who experience this condition die because of a prolonged response time from onset of the fatal arrhythmia to defibrillation by trained treatment providers. If athletic trainers or other members of the athletic care medical team are trained as target responders and equipped with automated electronic defibrillators, they can immediately treat an athlete who experiences a sudden, life-threatening tachyarrhythmia. This prompt response to the life-threatening emergency should result in a higher survival rate. DESCRIPTION: We review the causes of sudden cardiac arrest during athletic events, note some unusual clinical presentations, discuss improved methods of response and new equipment for treatment, and define the athletic trainer's role as a target responder trained to treat people experiencing sudden cardiac arrest at an athletic event. CLINICAL ADVANTAGES: An athletic care team willing to become part of an emergency response team can help improve the survival rate of athletes experiencing sudden cardiac arrest at an athletic event.
Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease (2013)

Presented mechanism can explain why moderate inhibition of γ-secretase cannot lead to effective therapies, the pharmacodynamics of Aβ-rebound phenomenon, and recent failures of the major drug-candidates such as semagacestat. Novel improved drug-candidates can be prepared from competitive inhibitors that can bind to different sites on γ-secretase simultaneously. Our quantitative analysis of the catalytic capacity can facilitate the future studies of the therapeutic potential of γ-secretase and the pathogenic changes in Aβ metabolism.
084 Effect of Omnigen-AF on the preweaning performance of beef calves (2017)

The objective of this research was to determine the effects of feeding OmniGen-AF (OG; Phibro Animal Health Corp., Teaneck, NJ) to mature cows (n = 112) and primiparous heifers (n = 48) from 60 d before calving to breeding and to their calves in creep feeds for 90 d before weaning on calf performance. Mature cows were randomized into 16 pasture groups by age and heifers were randomized into 4 pasture groups at the University of Arkansas Southwest Research and Extension Center from 60 d prior projected calving to breeding (December 15, 2015, through May 2, 2016). Corn gluten feed was supplemented to all cows at 1.4 kg·cow−1·d−1, prorated for 5 d/wk feeding (2.5 kg/cow). Cows were fed OG a daily rate of 4 g/45.4 kg. Calves (n = 146) were born between February 10 and April 15, with an average calving date of March 1. Creep feed (67% soybean hulls and 33% corn gluten feed, as-fed basis) was offered at 1% BW from July 14 through October 7, 2016. Calves were offered OG at a daily rate of 4 g/45.4 kg in the creep feed. A subset of heifer calves in each pasture (n = 3/pasture) were inserted with an intravaginal device containing a temperature data recorder for a 9-d period during September, and core body temperatures (CBT) were recorded every 20 min. Birth date, birth weight, BW, and BW change of calves were recorded and analyzed as CRD by ANOVA, using the mixed procedure of SAS. Fixed effects included treatment, parity group, and the treatment × parity interaction, with sire (AI vs. natural service) and birth date included as covariables and pasture within treatment as the random effect. Analysis of CBT was conducted as a repeated measures analysis by hour with day as the repeated measure and calf as the subject. Calves supplemented with OG gained more BW (P = 0.03) than control calves during the creep feeding period (80.7 vs. 72.5 kg, respectively); however, BW at weaning did not differ (P = 0.27). A treatment × hour interaction (P < 0.01) for CBT was observed, with OG-supplemented heifers having numerically lower CBT (−0.7°C; P = 0.19) at 1400 h than control heifers. Providing OG in the creep diet of calves was shown to have a positive influence on BW gain before weaning. Numerically lower CBT may indicate less heat stress in OG-supplemented calves, but more research is needed to further substantiate these effects.
Abstract 355: A monoclonal antibody against laminin alpha 4 inhibits both MCAM and integrin-a6b1 binding, blocks tumor cell adhesion in vitro and slows melanoma tumor growth in vivo (2015)

Abstract Laminin is an extracellular matrix molecule that is secreted as a trimeric protein composed of an α, β and γ chain. There are five distinct laminin α chains that impart distinct binding and signaling activities for cell adhesion, migration, and differentiation in a tissue-specific fashion. Laminin a4 (LAMA4) is expressed by vascular endothelial cells throughout the body, but is also overexpressed by cells within tumors of different origin compared to healthy human tissue. LAMA4 serves as a ligand for the cell adhesion receptors MCAM and a6b1 integrin, as well as for cell surface heparin sulfate proteoglycans. In order to probe how the MCAM/Laminin interaction contributes to tumor growth, we screened for LAMA4-specific monoclonal antibodies that block MCAM binding. We identified several such antibodies, and found that a subset also inhibits LAMA4 binding to a6b1 integrin, indicating that MCAM and a6b1 integrin recognize a similar region of LAMA4. Examining cells from multiple types of tumors, we found that these antibodies were potent inhibitors of tumor cell adhesion to LAMA4 in vitro. Finally, with in vivo administration, we demonstrated dose-dependent inhibition of human melanoma tumor growth in a mouse xenograft model, accompanied by morphologic changes in LAMA4 tumor distribution. These findings suggest that the MCAM/a6b1 integrin binding activity of LAMA4 contributes to both tumor adhesion and growth and that LAMA4 may provide a therapeutic drug target for several different oncology indications. Citation Format: Stephen J. Tam, Lauri E. Li, Carlos Lorenzana, Yue Liu, Ken Flanagan, Philip J. Dolan, Lana Alexander, Josh Salmans, Robin M. Barbour, Jeffrey N. Higaki, Tarlochan Nijjar, Wagner Zago, Ted A. Yednock, Gene Kinney. A monoclonal antibody against laminin alpha 4 inhibits both MCAM and integrin-a6b1 binding, blocks tumor cell adhesion in vitro and slows melanoma tumor growth in vivo. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 355. doi:10.1158/1538-7445.AM2015-355
Oligonucleotide and Water Self-Diffusion in Systems of Pluronic Triblock Copolymers and in Buffer Solutions by Pulsed Field Gradient Nuclear Magnetic Resonance (2000)

Pulsed field gradient nuclear magnetic resonance (PFGNMR) measurements of oligonucleotide (poly-thymidine, T1 to T30) self-diffusion coefficients in gels of Pluronic [poly(ethylene oxide) (PEO)−poly(propylene oxide) (PPO)−poly(ethylene oxide) (PEO)] micelles follow the Zimm scaling theory that predicts the diffusion coefficient to vary with solute molecular weight to the −0.5 power. The ratio of the diffusion coefficients in a 20% Pluronic gel-like liquid crystal phase to those in buffer solutions (without Pluronics) was approximately equal to 0.5 for all molecule sizes tested. PFGNMR water self-diffusion coefficient measurements in the gel phase and the solution phase of Pluronic micelles were interpreted within the context of volume averaging theory and known structural features of Pluronic micelles for various Pluronic concentrations. The result of combining the volume averaging theory and measurements of water and oligonucleotide self-diffusion indicates that the geometrical constraints of the Pluronic structure are sufficient to explain the majority of the oligonucleotide self-diffusion coefficient reduction in the Pluronic gel-like system.
Las Ortografías de Mayans y Bordazar: el fondo de una polémica (1990)

En 1730 se publicó la segunda edición de la Ortografía Española del impresor valenciano Antonio Bordazar de Artazú. El tratado fue en principio uno más entre los muchos que aparecieron a lo largo del siglo, incluso después de la publicación de la primera Ortografía académica de 1741. Sin embargo, la obra ha merecido una atención particular por una cuestión en gran parte ajena a su contenido doctrinal y relacionada, en cambio, con una de las características del ambiente cultural de nuestro siglo XVIII. Se trata de la polémica desatada en torno a la autoría de la obra, en la que intervinieron de forma activa personajes como Mañer y que enfrentó a dos de las figuras principales de aquel siglo: Feijoo y Mayans. La información sobre los datos históricos de la polémica y la publicación de las principales cartas en las que se plasmó han centrado hasta ahora la atención de los autores que se han ocupado del tema. No se ha abordado, sin embargo, lo que constituye el fondo de la cuestión y a lo que Mayans aludió repetidamente como prueba que zanjaría cualquier especulación. Se trata del cotejo de su propio sistema ortográfico con el expuesto por Bordazar.
Controller design with regional pole constraints - Hyperbolic and horizontal strip regions (1992)

Peer Reviewed
ChemInform Abstract: Reaction of Sodium Cyanide with 5‐Bromo‐1‐benzosuberone: A Reappraisal. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
20 GHz bandwidth 1.5 μm wavelength VUG DFB laser using a zero net strain In x Ga 1− x As y P 1− y well active structure grown at constant y (1993)

A 20 GHz bandwidth VUG (V-on-U groove) DFB GalnAsP laser based on a zero net strain quaternary quantum well active structure grown at a constant phosphorus/arsenic ratio is described. The active structure is designed such that emission wavelength has excellent thermal stability in order to avoid gain peak shifts during two epitaxial regrowths. Using this active material, the Letter shows that highperformance high-speed DFB devices can be designed and fabricated.
Diamond Nanowire Transistor with High Current Capability (2022)

Carrier confinement in nanowire (NW) structures can offer a host of new material properties compared to bulk electronic devices. Diamond can be considered an ultimate semiconductor given its superlative electronic, physical, and optical properties. However, the development of diamond device technology has been hindered by doping problems in conventional device structures. Here, heavily doped diamond NWs, some 15 nm wide and only 1–2 nm deep overcome these issues and offer a significant advance in NW technology; transistor action can be induced with remote side gates alone, without the need for semiconductor junctions. Quasi‐ballistic transport is most‐likely responsible for extraordinary current handling capability of the NW transistors fabricated here at some 20 MA cm −2 , being around 0.04 G 0. This unipolar technology opens up a new paradigm in diamond nanoelectronic device technology.
Screening, Mutagenesis of Nitrite‐Degrading Lactobacilli in Chinese Traditional Fermented Sauerkraut and its Application in the Production of Sauerkraut (2016)

Abstract Sauerkraut is a Chinese traditional fermented vegetable product. However, excessive nitrite in sauerkraut may cause food safety problems. This study screened three highly‐efficient nitrite‐degrading lactobacilli, namely, B1, C1 and D2, with over 75% degradation rate. According to the morphology, physiological and biochemical characteristics, as well as the 16S rDNA analysis, we found that B1 belonged to Lactobacillus pentosus , whereas C1 and D2 belonged to Lactobacillus plantarum . After ultraviolet (UV)‐nitrosoguanidine compound mutation, the degradation rates of the three lactobacilli to nitrite improved by 5.8, 8.0 and 12.7%, respectively. After the acclimation of sauerkraut juice with 80% concentration, single lactobacillus and mixed lactobacilli were applied in the sauerkraut product. The results indicated that the degradation effects of mixed strains on nitrite were better than that of single one. Compared with the control group (0–36.6 mg/kg), the mixed strains inoculated in the early fermentation period can significantly decrease the nitrite residue in sauerkraut (0–20.8 mg/kg) and the fermentation period can be shortened from 30 to 20 days. The sauerkraut produced showed good quality and flavor. Therefore, this study has significant application value for industrial production of sauerkraut. Practical Applications Nitrite formed in traditional fermented sauerkraut is an unsolved safety problem. This study screened three highly‐efficient nitrite‐degrading lactobacilli strains. After ultraviolet (UV)‐nitrosoguanidine compound mutation, the degradation rates of the three lactobacilli to nitrite were over 81.5%. Compared with the control group (36.6 mg/kg), the mixed strains inoculated in the early fermentation period could significantly decrease the nitrite residue in sauerkraut (20.8 mg/kg) and the fermentation period could be shortened from 30 to 20 days. Therefore, this study has significant application value for the industrial production of sauerkraut.
Monitoring Nonsurgical and Surgical Root Canal Treatment of Teeth with Primary and Secondary Infections (2014)

The aim of this study was to monitor nonsurgical and surgical root canal treatment (RCT) of teeth with primary and secondary infections and apical periodontitis (AP). This prospective clinical study comprised the treatment of 80 patients with primary and persistent secondary infections and AP. Of this initial sample, forty patients did not return. Periapical index using cone beam computed tomography scans (CBCTPAI) was used to aid diagnosis, planning and to determine the better therapeutic strategy. Twenty patients (26 teeth) diagnosed with primary infection and AP received conventional RCT and were followed up for 10 to 36 months. Twenty patients (31 teeth) diagnosed with persistent secondary infection were submitted to periapical surgical and followed up for 6 to 30 months. The results showed RCT successful in 19/26 cases with complete AP healing (5/26 with partial repair) in 10-36 months of follow up. For the surgically managed cases, effectiveness of surgical therapy was detected in 10/31 cases with complete healing (10/31 cases with partial repair) within 6-30 months follow up. The return of patients for clinical and radiographic follow-up, and obedience to the proposed time period was very short from ideal. The levels of success in both therapeutic protocols were high. RCT failures were detected even with rigorous standard clinical protocols.