gebhart/patrepeval huggingface dataset:
Whole-organ enzymology of the creatine kinase system in heart (1991)

Conference Article| November 01 1991 Whole-organ enzymology of the creatine kinase system in heart Joanne S. Ingwall Joanne S. Ingwall 1N.m.r. Laboratory for Physiological Chemistry, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (4): 1006–1010. https://doi.org/10.1042/bst0191006 Article history Received: August 09 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Joanne S. Ingwall; Whole-organ enzymology of the creatine kinase system in heart. Biochem Soc Trans 1 November 1991; 19 (4): 1006–1010. doi: https://doi.org/10.1042/bst0191006 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: [Ca+], external calcium ion concentration This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Search for Heavy Neutrinos and WR Bosons with Right-Handed Couplings in a Left-Right Symmetric Model in pp Collisions at √s=7 TeV (2012)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Analysis and design of a multi-tapped high-frequency auto-transformer based inverter system (2016)

The Google Little Box Challenge, an open competition to build the world smallest 2 kW Photo-Voltaic (PV) inverter, triggered a trend in the power electronic community to design PV inverter systems with a very high power density. In particular, in this paper, a novel single-phase non-isolated PV inverter topology is presented, achieving both high efficiency and high power density. The proposed solution takes advantage of a highly efficient resonant DC-DC stage to generate multiple intermediate DC voltage levels; these levels are then modulated by means of a high-frequency operating tap-selector and the resulting waveform is filtered and unfolded to obtain a low-frequency sinusoidal voltage at the output. Only a fraction of the full DC-link voltage is switched in every commutation of the tap-selector, consequently the occurring switching losses are reduced with respect to single-stage PWM inverters. At the core of the DC-DC stage, a high-frequency auto-transformer with multiple output taps is employed. Since it is realized only with a single winding and a fraction of the input current directly flows to the output, its utilization increases the efficiency and reduces the volume with respect to an equivalent transformer based solution. A detailed analysis of the working principle of the investigated inverter is presented in this paper together with a Pareto optimal design, focusing in particular on the resonant operation and on the modeling of the autotransformer. The performance in terms of losses and volume is finally provided for the optimal solution.
Transition from cylindroma to spiradenoma in CYLD‐defective tumours is associated with reduced DKK2 expression (2011)

Patients carrying heterozygous germline truncating mutations in the CYLD gene develop multiple primary hair follicle-related tumours. A highly patterned tumour, termed cylindroma, and a highly disorganized tumour, termed spiradenoma, may both develop in the same patient. Furthermore, histological features of both tumour types have been described within the same tumour specimen. We used three-dimensional computer-aided reconstruction of these tumours to demonstrate contiguous growth of cylindromas into spiradenomas, thus suggesting a transition between the two tumour types. To explore factors that may influence cutaneous tumour patterning, genome-wide transcriptomic analysis of 32 CYLD-defective tumours was performed. Overexpression of the Wnt/β-catenin signalling pathway was observed relative to normal perilesional tissue. Morphometric analysis was used to investigate the relationship between Wnt pathway-related gene expression and tumour organization. This revealed an association between reduced Dickkopf 2 (DKK2-a negative regulator of the Wnt/β-catenin signalling pathway) expression and loss of tumour patterning. Reduced DKK2 expression was associated with methylation of the DKK2 gene promoter in the majority of tumour samples assayed. RNA interference-mediated silencing of DKK2 expression in cylindroma primary cell cultures caused an increase in colony formation, cell viability, and anchorage-independent growth. Using these data, we propose a model where epigenetic programming may influence tumour patterning in patients with CYLD mutations.
Tuberculosis, Pulmonary Cavitation, and Matrix Metalloproteinases (2014)

Abstract Tuberculosis (TB), a chronic infectious disease of global importance, is facing the emergence of drug-resistant strains with few new drugs to treat the infection. Pulmonary cavitation, the hallmark of established disease, is associated with very high bacillary burden. Cavitation may lead to delayed sputum culture conversion, emergence of drug resistance, and transmission of the infection. The host immunological reaction to Mycobacterium tuberculosis is implicated in driving the development of TB cavities. TB is characterized by a matrix-degrading phenotype in which the activity of proteolytic matrix metalloproteinases (MMPs) is relatively unopposed by the specific tissue inhibitors of metalloproteinases. Proteases, in particular MMPs, secreted from monocyte-derived cells, neutrophils, and stromal cells, are involved in both cell recruitment and tissue damage and may cause cavitation. MMP activity is augmented by proinflammatory chemokines and cytokines, is tightly regulated by complex signaling paths, and causes matrix destruction. MMP concentrations are elevated in human TB and are closely associated with clinical and radiological markers of lung tissue destruction. Immunomodulatory therapies targeting MMPs in preclinical and clinical trials are potential adjuncts to TB treatment. Strategies targeting patients with cavitary TB have the potential to improve cure rates and reduce disease transmission.
Evaluation of F2 and F3 plants introgressed with QTLs for clubroot resistance in cabbage developed by using SCAR markers (2005)

Clubroot disease caused by Plasmodiophora brassicae is one of the major diseases of Brassica crops, often devastating to the cultivation of cruciferous crops in temperate regions. In a previous study (Moriguchi et al. 1999) identified three major quantitative trait loci (QTLs) for clubroot resistance, each in a separate linkage group, in a population derived from a cross between a clubroot-susceptible inbred cabbage line, Y2A and a resistant inbred kale line, K269. In this study, the original random amplified polymorphic DNA (RAPD) and restriction fragment length polymorphism (RFLP) markers were converted into sequence-characterized amplified region (SCAR) markers to facilitate large-scale marker-assisted screening of clubroot resistance in cabbage breeding. Of 15 RAPD markers closely linked to the three QTLs, nine SCARs were developed as dominant markers after cloning and sequencing. In addition, two RAPD markers were converted into co-dominant cleaved amplified polymorphic sequence (CAPS) markers, and one RFLP marker out of three tested was converted to a dominant SCAR marker. The effect of selection for resistance by the improved markers was evaluated in progeny plants in the F2 and F3. A total of 138 F2 plants were genotyped with nine SCARs and 121 well-distributed makers consisting of 98 RAPD, 19 RFLP, two isozymes, and two morphological markers in order to estimate the level of resistance and the proportion of undesirable alleles from the kale in non-target areas in each of the F2 populations. An F2 plant, YK118, had kale alleles at QTL1, QTL3 and QTL9. Three F2 plants, namely, YK107, YK25 and YK51 had kale alleles at only QTL1, QTL3 and QTL9, respectively. These F2 plants were selected for their low proportion of alleles derived from kale in non-target regions. YK118, like the resistant kale parent, expressed very high resistance to three field isolates of Plasmodiophora brassicae, whereas the mean disease index in the F2 and F3 plants carrying only single QTLs was intermediate. The QTLs showed no differential response to the isolates. These plants with improved resistance will be useful as parental inbred lines for F1 hybrids.
Cohesive Zone Modeling of Ductile Crack Growth in Circumferential Through-Wall-Cracked Pipe Tests (2011)

Cohesive zone modeling has been shown to be a convenient and effective method to simulate and analyze the ductile crack growth behavior in fracture specimens and structures. However, the cohesive zone modeling has not been applied to simulate the ductile crack growth behavior of a circumferential through-wall cracked pipe. In this paper, cohesive zone modeling has been applied to simulate the ductile crack growth of a past through-wall-cracked pipe test that was conducted during Degraded Piping Program. The ABAQUS code was used for the three-dimensional finite element analysis. The bending moment at crack initiation, maximum bending moment, crack extension, and J-integral values were calculated from the finite element analysis. These results were compared with the experimental results. In addition, results obtained from an existing J-estimation scheme (LBB.ENG2) were provided for comparison. All results showed reasonable agreement. The results of the present study demonstrate that the cohesive zone modeling can be applied to simulate the ductile crack growth behavior of a through-wall cracked pipe.
Stochastic Detectability and Mean Bounded Error Covariance of the Recursive Kalman Filter with Markov Jump Parameters (2010)

In this article, we study the error covariance of the recursive Kalman filter when the parameters of the filter are driven by a Markov chain taking values in a countably infinite set. We do not assume ergodicity nor require the existence of limiting probabilities for the Markov chain. The error covariance matrix of the filter depends on the Markov state realizations, and hence forms a stochastic process. We show in a rather direct and comprehensive manner that this error covariance process is mean bounded under the standard stochastic detectability concept. Illustrative examples are included.
Acute Pancreatitis (1994)

From mild disease to multiorgan failure and sepsis, acute pancreatitis is a disorder that has numerous causes, an obscure pathogenesis, few effective remedies, and an often unpredictable outcome. In 1925, Moynihan aptly described the dramatic nature of acute pancreatitis as the “most terrible of all calamities that occur in connection with the abdominal viscera. The suddenness of its onset, the illimitable agony which accompanies it, and the mortality attendant upon it render it the most formidable of catastrophes”1. Just over 100 years ago, Reginald Fitz2 described many of the modern clinical and pathologic features of severe acute pancreatitis3. . . .
Extensions of Broad Brands: The Role of Retrieval in Evaluations of Fit (1996)

Brand breadth is a function of not only the number and variability of products represented by the brand but also of the strength of association between the brand and the products it represents. The strength of association is reflected in the re‐trievability from memory of product associations. This, in turn, influences the evaluation of fit of brand extensions. Two types of brands were studied: those with a strong association to a single product (and weaker associations with other products) and those with strong associations to multiple products. Results from an experiment showed that for brands with a single product association, brand knowledge and context interact to influence evaluations of fit for extensions to products weakly associated with the brand. For brands strongly associated with more than 1 product, context influences evaluations of the fit of brand extensions.
Empirical Bayesian energy estimation for multi-voltage threshold digitizer in PET (2013)

Multi-voltage threshold (MVT) digitization is a cost-effective low-power sampling solution for fast scintillation pulse signal sampling, which has been proven to be practical in our preclinical scanner - Trans-PET BioCaliBurn. However, MVT digitization does not provide the amplitude information directly, while regular-time sampling (RTS) provides energy information as an integral form. This work focuses on event energy estimation for MVT digitizer, which is a crucial task for scintillation detection systems. Generally, critical scintillation pulses characteristics related with MVT can be summarized as: a. fixed pulse shape; b. fast leading edge; c. relatively slow decay; d. filtered Poisson noise. Based on these knowledge, we propose an empirical method, referred to as the empirical Bayesian energy estimation (EBEE), to obtain the pulse energy for MVT samples. In EBEE method, event energy information is the assumed pulse height which maximizes a posteriori probability of the given MVT samples. To evaluate the method, we set up a library of scintillation pulses. Scintillation pulses in this digital library are obtained at a high sampling rate of 50 Giga-samples per second so that their waveforms are recorded with high accuracy. Evaluation results are implemented between EBEE and pulse fitting(PF). With eight voltage thresholds, 4.335 keV Root Mean Square Error (RMSE) is obtained by EBEE, while 18.464 keV RMSE by PF. The evaluation shows that MVT of eight thresholds can produce nearly the same estimated energys as 50 GSps RTS when the MVT digitizer works with EBEE. The results have therefore demonstrated the potential advantage of EBEE in energy measurement for the MVT digitizer.
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria (2023)

Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partially or even entirely resistant to known antibiotics. AMR is caused by several mechanisms, among which the (over)expression of multidrug efflux pumps plays a central role. Multidrug efflux pumps are transmembrane transporters, naturally expressed by Gram-negative bacteria, able to extrude and confer resistance to several classes of antibiotics. Targeting them would be an effective way to revive various options for treatment. Many efflux pump inhibitors (EPIs) have been described in the literature; however, none of them have entered clinical trials to date. This review presents eight families of EPIs active against Escherichia coli or Pseudomonas aeruginosa. Structure–activity relationships, chemical synthesis, in vitro and in vivo activities, and pharmacological properties are reported. Their binding sites and their mechanisms of action are also analyzed comparatively.
The Accessory Posterolateral Nerve: An Immunohistological Analysis (2012)

This histological study supports prior descriptions defining a newly recognized neural pathway for innervation of the nasal mucosa. Our data confirm that these accessory posterolateral nerves project directly through the perpendicular plate of the palatine bone and are composed of autonomic fibers. Recognition of this pathway may be exploited in the treatment of sinonasal disease resulting from autonomic dysregulation.
A novel digital predistortion technique for class-E PA with delay mismatch estimation (2011)

This paper proposes a polynomial-based adaptive digital predistortion (DPD) method with delay mismatch estimation for the class-E power amplifier (PA), which can compensate the AM-AM and the strong AM-PM distortion produced by the switching operation of class-E PA. On the other hand, due to the strict requirement of timing alignment in polar transmission, a low-complexity correlation-based scheme for delay mismatch estimation and compensation filter is developed. Simulation results confirmed that the proposed DPD can improve the EVM performance from 5.67% to 0.72%, leading also to 18 dB rejection of spectrum re-growth under the condition of perfect timing alignment. The results also reveal that our proposed method of digital predistortion with delay mismatch estimation, as well as delay mismatch compensation has 1% EVM improvement as compared with applying DPD method directly without timing alignment.
Nano Letters in the Time of COVID-19 (2022)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNano Letters in the Time of COVID-19Teri W. OdomTeri W. OdomMore by Teri W. Odomhttps://orcid.org/0000-0002-8490-292XCite this: Nano Lett. 2022, 22, 1, 1–2Publication Date (Web):January 4, 2022Publication History Published online4 January 2022Published inissue 12 January 2022https://doi.org/10.1021/acs.nanolett.1c04813Copyright © 2022 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views4272Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (565 KB) Get e-AlertsSUBJECTS:Batteries,COVID-19,Magnetic materials,Nanoscience,Two dimensional materials Get e-Alerts
A standardized kodecyte method to quantify ABO antibodies in undiluted plasma of patients before ABO‐incompatible kidney transplantation (2019)

The kodecyte assay is a simple method that requires no sample dilution, and an optimized two-cell kodecyte panel is potentially capable of informing ABO-incompatible kidney transplantation decisions based on antibody levels.
Synthesis of switched-capacitor circuits simulating canonical reactance sections (1985)

A design method is described for switched-capacitor (SC) circuits based on the simulation of doubly terminated reactance filters in canonical tandem section configuration, employing the bilinear <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</tex> -to- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</tex> - transformation. The SC circuits are completely insensitive to parasitic capacitances. The approach permits the SC realization not only of all types of minimum phase <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</tex> -filters (low-pass, high-pass, bandpass, and bandstop filters with arbitrarily situated finite transmission zeros), which have been described previously but also of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</tex> -allpasses and nonreciprocal lossless two-ports.
Holy and Unholy Rites: Lies and Mistakes in Liturgy (2017)

Kieran Flanagan is a Reader in Sociology at the University of Bristol. His publications and research so far have been about various aspects of the sociology of religion, particularly liturgy, ethics and identities, but also the presentation of religions in visual media. Since the Second Vatican Council, there has been a tendency amongst theologians and liturgists to give modern culture a benign, undifferentiated &quot;reading&quot;, one innocent of the sociological complications such a view poses. A stress on incarnational theology gave a blanket blessing to culture, that was not offset by an awareness of the degree to which it has ambiguous, limited qualities that beg questions of meaning. Within an inductive approach to liturgy, the implications of a virtuous dissimulation emerge. The actor confronts particular dilemmas in practice that require regulation and disguise, if the social act of worship is to be accomplished in an authentic and intended manner.
Evaluation and Correction of the Non-linear Distortion of CEBAF Beam Position Monitors (2011)

The beam position monitors at CEBAF have four antenna style pickups that are used to measure the location of the beam. There is a strong nonlinear response when the beam is far from the electrical center of the device. In order to conduct beam experiments at large orbit excitation we need to correct for this nonlinearity. The correction algorithm is presented and compared to measurements from our stretched wire BPM test stand.
Pulsed Laser Deposited ZnO for Thin Film Transistor Applications (2008)

The film growth conditions were optimized for pulsed laser deposited ZnO thin films for high performance field effect transistor applications. Transistors fabricated on Si and GaAs substrates with various gate lengths and gate widths and demonstrated current on/off ratios better than 1012, current density of &gt;700mA/mm, sub-threshold gate voltage slope of 109mV/decade, current gain cutoff frequency of 500MHz, and power gain cutoff frequency of 400MHz (2um gate device).
Absence Seizures Induce a Decrease in Cerebral Blood Flow: Human and Animal Data (1996)

Our previous studies on cerebral metabolic activity in genetic absence epilepsy rats from Strasbourg (GAERS) were in favor of decreased functional activity during absences and normal or increased interictal activity. To ascertain that hypothesis, in the present study we performed continuous measurements of CBF in both children with typical absence epilepsy and GAERS, using Doppler ultrasonography and laser-Doppler flowmetry, respectively. CBF fluctuations during absences were recorded in four children between 5 and 6 years of age and 16 adult GAERS. In both children and animals, CBF measured in the middle cerebral artery and cortical capillaries, respectively, significantly decreased by a median value of 20-24% under basal levels during spontaneous absences. In GAERS, CBF levels were continuously decreased during haloperidol-induced absence status epilepticus, while they were not affected by ethosuximide. Conversely, convulsive seizures induced in rats either by kainate or picrotoxin led to a 175-664% increase in CBF levels. In conclusion, the present data show that during spontaneous absences, CBF decreases under basal levels in both cortical capillaries (GAERS) and the middle cerebral artery (children). Moreover, these fluctuations occur in vessels with normal vascular reactivity, are not mediated by changes in PO2, PCO2, or arterial blood pressure, and represent rather a response to reduced metabolic demand.