gebhart/patrepeval huggingface dataset:
Aims and Results of the NIMH Systematic Treatment Enhancement Program for Bipolar Disorder (STEP‐BD) (2011)

The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) was funded as part of a National Institute of Mental Health initiative to develop effectiveness information about treatments, illness course, and assessment strategies for severe mental disorders. STEP-BD studies were planned to be generalizable both to the research knowledge base for bipolar disorder and to clinical care of bipolar patients. Several novel methodologies were developed to aid in illness characterization, and were combined with existing scales on function, quality of life, illness burden, adherence, adverse effects, and temperament to yield a comprehensive data set. The methods integrated naturalistic treatment and randomized clinical trials, which a portion of STEP-BD participants participated. All investigators and other researchers in this multisite program were trained in a collaborative care model with the objective of retaining a high percentage of enrollees for several years. Articles from STEP-BD have yielded evidence on risk factors impacting outcomes, suicidality, functional status, recovery, relapse, and caretaker burden. The findings from these studies brought into question the widely practiced use of antidepressants in bipolar depression as well as substantiated the poorly responsive course of bipolar depression despite use of combination strategies. In particular, large studies on the characteristics and course of bipolar depression (the more pervasive pole of the illness), and the outcomes of treatments concluded that adjunctive psychosocial treatments but not adjunctive antidepressants yielded outcomes superior to those achieved with mood stabilizers alone. The majority of patients with bipolar depression concurrently had clinically significant manic symptoms. Anxiety, smoking, and early age of bipolar onset were each associated with increased illness burden. STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders.
ChemInform Abstract: Polynuclear Metal Complexes with Bridging Carbene or Carbyne Ligands. Part 50. Synthesis and Crystal Structures of the Complexes (RuW3(μ‐CO)(μ3‐η‐CO)(μ‐CPh)2(μ3‐CPh)(CO)2(η‐C5H5)3) and (RuW3(μ‐CO)(μ3‐η‐CO)(μ‐C(Ph)C(O))(μ‐CPh)(μ3‐CPh)(CO)(PMePh2)# (η‐C5H5)3). (1987)

Abstract The 3:1 molar reaction of the alkylidyne‐W complexes (I) with the Ru(0) complexes (II) leads to a chromatographically separable mixture of the cluster compounds (III) and (IV).
Solution Processable Direct Bandgap Copper‐Silver‐Bismuth Iodide Photovoltaics: Compositional Control of Dimensionality and Optoelectronic Properties (2022)

Abstract The search for lead‐free alternatives to lead‐halide perovskite photovoltaic materials resulted in the discovery of copper(I)‐silver(I)‐bismuth(III) halides exhibiting promising properties for optoelectronic applications. The present work demonstrates a solution‐based synthesis of uniform Cu x AgBiI 4+ x thin films and scrutinizes the effects of x on the phase composition, dimensionality, optoelectronic properties, and photovoltaic performance. Formation of pure 3D CuAgBiI 5 at x = 1, 2D Cu 2 AgBiI 6 at x = 2, and a mix of the two at 1 &lt; x &lt; 2 is demonstrated. Despite lower structural dimensionality, Cu 2 AgBiI 6 has broader optical absorption with a direct bandgap of 1.89 ± 0.05 eV, a valence band level at ‐5.25 eV, improved carrier lifetime, and higher recombination resistance as compared to CuAgBiI 5 . These differences are mirrored in the power conversion efficiencies of the CuAgBiI 5 and Cu 2 AgBiI 6 solar cells under 1 sun of 1.01 ± 0.06% and 2.39 ± 0.05%, respectively. The latter value is the highest reported for this class of materials owing to the favorable film morphology provided by the hot‐casting method. Future performance improvements might emerge from the optimization of the Cu 2 AgBiI 6 layer thickness to match the carrier diffusion length of ≈40–50 nm. Nonencapsulated Cu 2 AgBiI 6 solar cells display storage stability over 240 days.
Weak ferromagnetism in the molecular compound Cu(ta)(3-pic).cntdot.H2O(ta=terephthalato,3-pic=3-picoline). Crystal structure of Cu(ta)(3-pic)2.cntdot.0.5(3-pic).cntdot.0.5CH3OH (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWeak ferromagnetism in the molecular compound Cu(ta)(3-pic).cntdot.H2O(ta=terephthalato,3-pic=3-picoline). Crystal structure of Cu(ta)(3-pic)2.cntdot.0.5(3-pic).cntdot.0.5CH3OHEvangelos Bakalbassis, Pierre Bergerat, Olivier Kahn, Suzanne Jeannin, Yves Jeannin, Yves Dromzee, and Maurice GuillotCite this: Inorg. Chem. 1992, 31, 4, 625–631Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/ic00030a019https://doi.org/10.1021/ic00030a019research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Carbon loading from nanoparticles to fibers for the electromagnetic absorption (2018)

International audience
Erythrocyte adenylate kinase isoenzyme as a marker for hemolysis (1997)

The presence in serum of adenylate kinase isoenzyme originating from erythrocyte can be useful as a marker for detecting hemolysis. We have presented preliminary evidence for identifying hemolytic anemia patients earlier by determining erythrocyte AK isoenzyme activity in serum (or plasma) rather than using measurement of plasma hemoglobin concentration. This test being quite specific for hemolysis should find use as a quick method for estimating the extent of in vivo hemolysis in hemolytic patients earlier than heretofore possible.
Fluorescent Spectrophotometry in the Identification of Bacteria (1972)

S ummary : Preliminary results on a technique for identifying bacteria by spectrophoto‐fluorometry are presented. The 3 parameters involved, emission wavelength, excitation wavelength and intensity, are used to produce a topographic map characteristic of the fluorescence of the chemical bonds. Enhancement of the differences between species is possible using dyes such as acridine orange. Various improvements in the technique are presented.
Identification of a myometrial molecular profile for dystocic labor (2011)

These findings suggest an underlying molecular basis for dystocia in nulliparous women in spontaneous labor. Differentially expressed genes suggest an important role for the immune response in dystocic labor and may provide important indicators for new diagnostic assays and potential intrapartum therapeutic targets.
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents (2016)

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.
Anonymous Tracking Using RFID Tags (2007)

The increasing use of RFID tags in many applications have brought forth valid concerns of privacy and anonymity among users. One of the primary concerns with RFID tags is their ability to track an individually tagged entity. While this capability is currently thought to be necessary for supporting some features of RFID systems, such practice can lead to potential privacy violations. In this paper, we propose a privacy-preserving scheme that enables anonymous estimation of the cardinality of a dynamic set of RFID tags, while allowing the set membership to vary in both the spatial and temporal domains. In addition, the proposed scheme can identify the dynamics of the changes in the tag set population. The main idea of the scheme is to avoid explicit identification of tags. We demonstrate that the proposed scheme is highly adaptive and can accurately estimate tag populations across many orders of magnitude, ranging from a few tens to millions of tags. The associated probing latency is also substantially lower (les 10%) than that of the schemes which require explicit tag identification. We also show that our proposed scheme performs well even in highly dynamic environments, where the tag set keeps changing rapidly.
Instant: A TSCH Schedule for Data Collection from Mobile Nodes (2019)

Low-power wearable devices are becoming increasingly important for fitness and healthcare applications. However, existing protocols based on the IEEE 802.15.4 low-power wireless standard are not optimized for data collection from mobile devices. This paper presents Instant: a schedule for the IEEE 802.15.4 TSCH protocol tailored for this application. We evaluate the data collection speed, energy consumption, and fairness of Instant, and show that Instant achieves several times higher data collection speed from mobile nodes compared with the state-of-the-art Orchestra schedule.
CVD Co and its application to Cu damascene interconnections (2010)

Fundamental material interactions as pertinent to nano-scale copper interconnects were studied for CVD Co with a variety of micro-analytical techniques. Native Co oxide grew rapidly within a few hours (XPS). Incorporation of oxygen and carbon in the CVD Co films (by AES and SIMS) depended on underlying materials, such as Ta, TaN, or Ru. Copper film texture (by XRD) and agglomeration resistance (by AFM) showed correlations with amounts of in-film oxygen/carbon. Cobalt diffused through copper at normal processing temperatures (by SIMS). CVD Co demonstrated diffusion barrier performance to Cu (by Triangular Voltage Sweep, TVS), but not to O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . CVD Co was applied to 32 nm/22 nm damascene Cu interconnect fabrication in a scheme defined by the material studies. Lower post-CMP defect density and longer electromigration lifetimes were obtained.
Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice (2016)

Aging diminishes bone formation engendered by mechanical loads, but the mechanism for this impairment remains unclear. Because Wnt signaling is required for optimal loading-induced bone formation, we hypothesized that aging impairs the load-induced activation of Wnt signaling. We analyzed dynamic histomorphometry of 5-month-old, 12-month-old, and 22-month-old C57Bl/6JN mice subjected to multiple days of tibial compression and corroborated an age-related decline in the periosteal loading response on day 5. Similarly, 1 day of loading increased periosteal and endocortical bone formation in young-adult (5-month-old) mice, but old (22-month-old) mice were unresponsive. These findings corroborated mRNA expression of genes related to bone formation and the Wnt pathway in tibias after loading. Multiple bouts (3 to 5 days) of loading upregulated bone formation-related genes, e.g., Osx and Col1a1, but older mice were significantly less responsive. Expression of Wnt negative regulators, Sost and Dkk1, was suppressed with a single day of loading in all mice, but suppression was sustained only in young-adult mice. Moreover, multiple days of loading repeatedly suppressed Sost and Dkk1 in young-adult, but not in old tibias. The age-dependent response to loading was further assessed by osteocyte staining for Sclerostin and LacZ in tibia of TOPGAL mice. After 1 day of loading, fewer osteocytes were Sclerostin-positive and, corroboratively, more osteocytes were LacZ-positive (Wnt active) in both 5-month-old and 12-month-old mice. However, although these changes were sustained after multiple days of loading in 5-month-old mice, they were not sustained in 12-month-old mice. Last, Wnt1 and Wnt7b were the most load-responsive of the 19 Wnt ligands. However, 4 hours after a single bout of loading, although their expression was upregulated threefold to 10-fold in young-adult mice, it was not altered in old mice. In conclusion, the reduced bone formation response of aged mice to loading may be due to failure to sustain Wnt activity with repeated loading. © 2016 American Society for Bone and Mineral Research.
Visual object-oriented programming (1993)

article Visual object-oriented programming Share on Author: Margaret M. Burnett Oregon State University Oregon State UniversityView Profile Authors Info & Claims ACM SIGPLAN OOPS MessengerVolume 5Issue 2April 1994 pp 127–129https://doi.org/10.1145/260304.261240Online:01 April 1993Publication History 3citation704DownloadsMetricsTotal Citations3Total Downloads704Last 12 Months26Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A New Analogue of Yessotoxin, Carboxyyessotoxin, Isolated from Adriatic Sea Mussels (2000)

A new analogue of yessotoxin (YTX), carboxyYTX, 3, was isolated from the digestive glands of mussels cultured on the Italian Adriatic coast. Its structure was determined by MS and NMR spectroscopy.
Photocontrolled Ring‐Opening Polymerization of Strained Dicarba[2]Ferrocenophanes: A Route to Well‐Defined Polyferrocenylethylene Homopolymers and Block Copolymers (2009)

The ring-opening polymerization (ROP) behavior of a variety of substituted 1,1'-ethylenylferrocenes, or dicarba[2]ferrocenophanes, is reported. The electronic absorption spectra and tilted solid-state structures of the monomers rac-[Fe(eta(5)-C(5)H(4))(2)(CHiPr)(2)] (7), [Fe(eta(5)-C(5)H(4))(2)(C(H)MeCH(2))] (8), and rac-[Fe(eta(5)-C(5)H(4))(2)(CHPh)(2)] (9) are consistent with the presence of substantial ring strain, which was exploited to synthesize soluble, well-defined polyferrocenylethylenes (PFEs) [Fe(eta(5)-C(5)H(4))(2)(C(H)MeCH(2))](n) (12) and [Fe(eta(5)-C(5)H(4))(2)(CHPh)(2)](n) (13) through photocontrolled ROP. Polymer chain lengths could be controlled by the monomer-to-initiator ratio up to about 50 repeat units and, consistent with the "living" nature of the polymerizations, sequential block copolymerization with a sila[1]ferrocenophane led to polyferrocenylethylene-polyferrocenylsilane (PFE-b-PFS) block copolymers (14 and 15). PFE polymers 12 and 13 showed two reversible oxidation waves, indicative of appreciable FeFe interactions along the polymer backbone. The diblock copolymers were characterized by NMR spectroscopy, GPC analysis, and cyclic voltammetry.
Evaluate Impact of Catalyst Type on Oil Yield and Hydrogen Consumption from Mild Hydrotreating (2014)

Bio-oil derived by fast pyrolysis of biomass represents a potentially attractive source of hydrocarbon transportation fuels. Raw bio-oil, however, is unsuitable for application as a fuel due primarily to high organic oxygen content, which imparts a number of undesirable properties including high acidity and low stability. These problems can be overcome by catalytic hydrodeoxygenation; however, removing oxygen to very low levels by hydrotreating carries a strong economic penalty. Mild hydrotreating (where moderate levels of deoxygenation take place) coupled with coprocessing in a petroleum refinery represents an alternative to deep hydrotreating which may improve the economics of manufacture of hydrocarbon transportation fuels from biomass. This study reports on the effect of catalyst type on the quality of bio-oil produced via mild hydrotreating in a semibatch reactor at three severities. Sulfided Ni–Mo/Al2O3, Pd/C(activated), Pd/char, Pt/char, and Ru/char were compared. Speciation of oxygen functional groups in distillate and bottom products was carried out, and the form of much of the organic oxygen was determined. These results show that a 55% conversion of the carbon in the biomass pyrolysis oil to a low-oxygen (5%), low-acid, volatile, hydrocarbon-miscible liquid product can be achieved. This was, however, possible only with the NiMo–S catalyst. The precious-metal catalysts while producing oil with acceptable carbon conversion, miscibility, and oxygen content did not convert enough acid to produce oil with acid numbers below 15. Water washing was successfully tested for removing residual acids. The various catalysts have different advantages, and using a different catalyst for the two stages of the process may provide the best process—for example ruthenium for minimizing coke during stabilization and nickel or platinum for deoxygenation.
Molecular Orientation at the Squalene/Air Interface from Sum Frequency Generation Spectroscopy and Atomistic Modeling (2021)

Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments, and squalene is a major ozone-active constituent. Here, we present a combined spectroscopic and atomistic modeling approach to elucidate the conformational and orientational preferences of squalene at the air/oil interface and their implications for reactions with ozone. We find that squalene chains have a tendency to align with the surface normal, resulting in different concentrations of the various types of its double bonds and thus different reactivities. We also observe the presence of water at the surface of this hydrophobic compound. Both findings have possible implications for the design and outcomes of kinetic models describing this important aspect of indoor air chemistry.
Electronegative Low-Density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated With Metabolic Syndrome (2017)

L5 induces adipose inflammation through LOX-1 by promoting macrophage maturation and infiltration into adipose tissue. Elevated plasma L5 levels may be a novel etiology of adipose tissue inflammation in patients with MetS.
Functional Characterization of the Primate Sperm Acrosomal Antigen (PSA‐63) (1995)

Monoclonal antibody (HS-63) raised in mice against human ejaculated sperm, polyclonal antibodies raised in rabbits against the cognate mouse testicular antigen (MSA-63; or Fab) and polyclonal antibodies raised in the rabbit against recombinant fusion proteins (GST-63) showed acrosomal localization in permeabilized rhesus monkey and human ejaculated sperm. Tail localization of the cognate primate sperm antigen (PSA-63) was also seen with intact MSA-63 antibodies and Fab fragments. The ability of these antibodies to inhibit sperm binding to the zona pellucida was measured with hemizona binding assays (HZAs). HS-63 (1.2 mg/ml) inhibited rhesus monkey sperm binding (mean +/- SEM) to homologous hemizonae (treatment, 15.5 +/- 3.3; control, 58.9 +/- 9.4; P < 0.025), whereas comparable concentrations of protein from nonimmunized mouse preparations were inactive (ascites fluid, 67.6 +/- 43.5; no ascites fluid, 72.0 +/- 44.6). Intact MSA-63 antibodies inhibited (up to 99%) monkey sperm-zona binding in a concentration-dependent manner. Moreover, inhibition in this case by intact MSA-63 antibody was limited to capacitated sperm. Similarly, intact MSA-63 antibodies inhibited (up to 85%) human sperm binding to homologous zonae in an antibody concentration-dependent manner. Fab fragments derived from MSA-63, when present in insemination mixtures (0.5 mg/ml), inhibited (P < 0.01) primate sperm binding to homologous hemizonae (monkey, 9.6 +/- 3; human sperm 9.4 +/- 2) compared with matched hemizona controls (monkey, 117 +/- 29; human, 20.4 +/- 3). Furthermore, rhesus monkey sperm-zona binding was reduced by 84% in the presence of rabbit anti-GST-63 antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)
Clinical Evaluation of Single-Dose Oral Bacampicillin or Ampicillin in Therapy of Uncomplicated Gonorrhea (1981)

Two hundred twenty-eight patients with uncomplicated gonorrhea who returned for follow-up cultures were evaluated for determination of the efficacy of three different regimens of single-dose oral treatment. The regimens included 2.4 g of bacampicillin plus 1.0 g of probenecid, 1.6 g of bacampicillin plus 1.0 g of probenecid, and 3.5 g of ampicillin plus 1.0 g of probenecid. All three regimens were highly effective in the treatment of urogenital and rectal gonorrhea but often failed cure pharyngeal gonorrhea. The highest rate of adverse reactions was reported for patients treated with 2.4 g of bacampicillin plus probenecid. The efficacies of a single oral dose of 1.6 g of bacampicillin (molar equivalent, 1.1 g of ampicillin) plus probenecid and of 3.5 g of ampicillin plus probenecid in the treatment of uncomplicated gonorrhea were equivalent as were the frequencies of adverse reactions to these two regimens.
Maxwell's Equations in the 21st Century (1993)

Maxwell's equations in the 21st Century The finite-difference time-domain method is a novel method for solving Maxwell's curl equations, especially when parallel-processing techniques are applied. The next generation of computers will bring a revolution by exploiting the use of parallel processing in computation to the maximum.
ChemInform Abstract: Tandem Reactions of Anions: A Short and Efficient Route to (.+‐.)‐ Anatoxin‐a (XI). (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.