gebhart/patrepeval huggingface dataset:
Diagnostic, Clinical and Post-SARS-CoV-2 Scenarios in Cancer Patients with SARS-CoV-2: Retrospective Analysis in Three German Cancer Centers (2021)

Oncologists face challenges in the management of SARS-CoV-2 infections and post-SARS-CoV-2 cancer treatment. We analyzed diagnostic, clinical and post-SARS-CoV-2 scenarios in patients from three German cancer centers with RT-PCR confirmed SARS-CoV-2 infection. Sixty-three patients with SARS-CoV-2 and hematologic or solid neoplasms were included. Thirty patients were initially asymptomatic, 10 of whom developed COVID-19 symptoms subsequently. Altogether 20 (32%) patients were asymptomatic, 18 (29%) had mild, 12 (19%) severe and 13 (20%) critical courses. Lymphocytopenia increased risk of severe/critical COVID-19 three-fold (<i>p</i> = 0.015). Asymptomatic course was not associated with age, remission status, therapies or co-morbidities. Secondary bacterial infection accompanied more than one third of critical COVID-19 cases. Treatment was delayed post-SARS-CoV-2 in 46 patients, 9 of whom developed progressive disease (PD). Cancer therapy was modified in 8 SARS-CoV-2 survivors because of deteriorating performance or PD. At the last follow-up, 17 patients had died from COVID-19 (<i>n</i> = 8) or PD (<i>n</i> = 9) giving an estimated 73% four-month overall survival rate. SARS-CoV-2 infection has a heterogenous course in cancer patients. Lymphocytopenia carries a significant risk of severe/critical COVID-19. SARS-CoV-2 disruption of therapy is as serious as SARS-CoV-2 infection itself. Careful surveillance will allow early restart of the anti-cancer treatment.
Suppression of Polarization Mode Dispersion Influence in Long Span Optical Repeater Transmission Systems (1993)

Recent investigations regarding long-haul high-speed transmission systems using Er-doped fiber amplifier repeaters have shown a possibility of realizing the systems of up to 10000 km transmission distance [1][2]. In these system, accumulated polarization dependencies, such as polarization mode dispersion (PMD) and polarization depending loss (PDL) in the fiber and EDFAs, induce a fading in bit error rate (BER) characteristic [3]-[5]. Polarization mode dispersion induces inter-symbol-interference (ISI) in IM-DD systems according to input polarization states because of propagation delay time between the two orthogonal eigen modes (principal states). This influence becomes a serious problem by increasing the bit rate or the transmission length. To avoid polarization mode dispersion influence, the authors have been proposed a "principal states transmission method [6]", which launches the signal light at one of principal states. However, the formerly proposed method can not be applied to optical repeater systems, which include optical isolators, because a pilot light is required to transmit in the opposite direction of the signal light in the same fiber.
Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells (2007)

Murine gammadelta T cell subsets, defined by their Vgamma chain usage, have been shown in various disease models to have distinct functional roles. In this study, we examined the responses of the two main peripheral gammadelta T cell subsets, Vgamma1(+) and Vgamma4(+) cells, during collagen-induced arthritis (CIA), a mouse model that shares many hallmarks with human rheumatoid arthritis. We found that whereas both subsets increased in number, only the Vgamma4(+) cells became activated. Surprisingly, these Vgamma4(+) cells appeared to be Ag selected, based on preferential Vgamma4/Vdelta4 pairing and very limited TCR junctions. Furthermore, in both the draining lymph node and the joints, the vast majority of the Vgamma4/Vdelta4(+) cells produced IL-17, a cytokine that appears to be key in the development of CIA. In fact, the number of IL-17-producing Vgamma4(+) gammadelta T cells in the draining lymph nodes was found to be equivalent to the number of CD4(+)alphabeta(+) Th-17 cells. When mice were depleted of Vgamma4(+) cells, clinical disease scores were significantly reduced and the incidence of disease was lowered. A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17.
Regionale virkninger av kulturhusprosjektet innOvata i Volda (2006)

Denne rapporten er dokumentasjonen av SNF-prosjekt 3340 om regionale virkninger av det planlagte kultursenteret innOvata i Volda.\nProsjektet ble gjennomført august til oktober 2006.
Novel Measurement Method to Study Thermal Aspects of Molding Mixture Decomposition (2018)

A wide variety of molding mixtures are extensively used in the process of the sand casting of metal components today. The sector is continuously developing in production volume; moreover, the expectations of customers are increasing on a monthly basis (also from a quality point of view). Even though mold and core manufacturing are well-organized routines in most foundries, technological problems still appear that can lead to technological problems and casting defects. These trends are forcing metal casters to come up with fitting strategies to solve their daily production challenges, while their suppliers are expected to keep up the continuous development of their existing foundry products and to find innovative solutions as well as new material combinations. Research on molding materials and their properties must, therefore, take a step forward accordingly to generate the necessary new knowledge to understand the behavior of mold and core mixtures during casting.This paper summarizes the latest results of a novel measurement method suitable for studying the degradation characteristics of different molding materials from a new perspective. The fundamentals of the method are based on a thermal analysis, focusing on the heat-absorption behavior of greensand and two types of chemically bonded sands regardless of the binder type and amount or the manufacturing process.
A Large-Scale Exploration of Factors Affecting Hand Hygiene Compliance Using Linear Predictive Models (2017)

This large-scale study, consisting of 24.5 million hand hygiene opportunities spanning 19 distinct facilities in 10 different states, uses linear predictive models to expose factors that may affect hand hygiene compliance. We examine the use of features such as temperature, relative humidity, influenza severity, day/night shift, federal holidays and the presence of new residents in predicting daily hand hygiene compliance. The results suggest that colder temperatures and federal holidays have an adverse effect on hand hygiene compliance rates, and that individual cultures and attitudes regarding hand hygiene exist among facilities.
Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (1990)

Insulin-like growth factor binding protein-3 (IGFBP-3) can modulate the mitogenic and metabolic effects of the insulin-like growth factors (IGFs). IGFBP-3 protein levels are developmentally regulated and influenced by a number of hormonal stimuli both in vitro and in vivo. As a first step toward understanding how hormonal and developmental factors regulate IGFBP-3 production, we are characterizing the human IGFBP-3 chromosomal gene and promoter. Southern analysis demonstrates a single copy of the IGFBP-3 gene in the human genome. This gene spans 8.9 kilobases; the protein-coding region is divided into four exons while a fifth exon contains the 3'-untranslated region. Primer extension studies locate the IGFBP-3 mRNA cap site 132 base pairs 5' to the ATG translation initiation codon. On the chromosomal gene, this cap site is located 30 base pairs 3' to the start of a TATA box and 97 base pairs 3' to a consensus GC upstream promoter element, an organization common to many eukaryotic promoters. When this potential IGFBP-3 promoter region is placed upstream to the chloramphenicol acetyltransferase reporter gene, it directs high-level production of chloramphenicol acetyltransferase in transfected COS-1 cells. These observations suggest an uncomplicated organization for the IGFBP-3 chromosomal gene and promoter in the human genome.
Building on a strong foundation (2021)

Ali Shilatifard

Just over 5 years ago, Science Advances launched with great expectations. Small at the start—five deputy editors and about 30 associate editors—the journal received 1865 submissions the first year. Our focus was to publish groundbreaking Research Articles and Reviews on a range of topics in an open-access format, providing content to a broad audience. Over the years, small but mighty has morphed into large and strengthening. To support journal growth, the board has now expanded to 38 deputy editors, active scientists who are leaders in their fields, and more than 250 scientists and engineers as associate editors (https://advances.sciencemag.org/content/editorialboard). In 2020, the journal received …
GPS and video data collection in Los Angeles County-a status report (2002)

Starting August, 1993, aCIM Co has driven thousands of miles of Los Angeles county streets to develop maps and video images tied to those maps. The practical problems in the data collection effort, the change in thinking that have to accompany a new technology with great promise and the new uses that have appeared as video images, precisely located, become available will be addressed. The technologies in the GeoVan are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury (2009)

Despite efforts aimed at developing novel therapeutics for traumatic brain injury (TBI), no specific pharmacological agent is currently clinically available. Here, we show that the pan-histone deacetylase (HDAC) inhibitor ITF2357, a compound shown to be safe and effective in humans, improves functional recovery and attenuates tissue damage when administered as late as 24 h postinjury. Using a well-characterized, clinically relevant mouse model of closed head injury (CHI), we demonstrate that a single dose of ITF2357 administered 24 h postinjury improves neurobehavioral recovery from d 6 up to 14 d postinjury (improved neurological score vs. vehicle; P< or =0.05), and that this functional benefit is accompanied by decreased neuronal degeneration, reduced lesion volume (22% reduction vs. vehicle; P< or =0.01), and is preceded by increased acetylated histone H3 levels and attenuation of injury-induced decreases in cytoprotective heat-shock protein 70 kDa and phosphorylated Akt. Moreover, reduced glial accumulation and activation were observed 3 d postinjury, and total p53 levels at the area of injury and caspase-3 immunoreactivity within microglia/macrophages at the trauma area were elevated, suggesting enhanced clearance of these cells via apoptosis following treatment. Hence, our findings underscore the relevance of HDAC inhibitors for ameliorating trauma-induced functional deficits and warrant consideration of applying ITF2357 for this indication.
Comparative Study on Enzymatic Properties of Acid Carboxypeptidase of Molds of the Genus Aspergillus (1972)

Journal Article Comparative Study on Enzymatic Properties of Acid Carboxypeptidase of Molds of the Genus Aspergillus Get access Eiji ICHISHIMA, Eiji ICHISHIMA The Laboratory of Microbiology and Enzymology, Tokyo Noko UniversityFuchu, Tokyo 183 Search for other works by this author on: Oxford Academic PubMed Google Scholar Shigenori SONOKI, Shigenori SONOKI The Laboratory of Microbiology and Enzymology, Tokyo Noko UniversityFuchu, Tokyo 183 Search for other works by this author on: Oxford Academic PubMed Google Scholar Keiko HIRAI, Keiko HIRAI The Laboratory of Microbiology and Enzymology, Tokyo Noko UniversityFuchu, Tokyo 183 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshiaki TORII, Yoshiaki TORII The Laboratory of Microbiology and Enzymology, Tokyo Noko UniversityFuchu, Tokyo 183 Search for other works by this author on: Oxford Academic PubMed Google Scholar Sadaji YOKOYAMA Sadaji YOKOYAMA The Laboratory of Microbiology and Enzymology, Tokyo Noko UniversityFuchu, Tokyo 183 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 72, Issue 4, October 1972, Pages 1045–1048, https://doi.org/10.1093/oxfordjournals.jbchem.a129967 Published: 01 October 1972 Article history Received: 18 April 1972 Published: 01 October 1972
Modeling Metalloenzymes with Density Functional and Mixed Quantum Mechanical/Molecular Mechanical (QM/MM) Calculations: Progress and Challenges (2011)

Abstract We discuss the application of density functional theory (DFT)‐based quantum chemical and mixed quantum mechanics/molecular mechanics (QM/MM) methods to the modeling of metalloenzyme chemistry. The state of the art of current approaches in terms of accuracy and reliability is considered, primarily in the context of two example systems, methane monooxygenase (MMO) and cytochrome P450. Key issues include the intrinsic accuracy of current DFT functionals for metal‐containing systems, modeling of conformational changes in protein structure, treatment of environmental electrostatic effects, use of spectroscopic calculations to help in identifying the structures of intermediates, and the validity of standard transition state theory approximations using a small number of optimized structures, as opposed to performing full statistical mechanical sampling with methods such as free energy perturbation theory. Considerable insight into the catalytic cycles of both MMO and P450 have been obtained over the past decade using existing computational methods, in close coupling with experimental efforts. However, significant challenges remain, both for the two systems that we consider here and for the modeling of metalloenzyme chemistry in the general case. A number of the most important of these challenges are identified and prospects for addressing them via improvements of the theoretical methodology are discussed.
Isoelectric Focusing Followed by Silver Staining (1984)

Cerebrospinal fluid (CSF) and serum samples from 361 consecutive patients were investigated. The protein pattern of each sample was examined by isoelectric focusing (IEF) of unconcentrated CSF followed by silver staining and by agar gel electrophoresis of concentrated CSF stained with amido black. 347 paired samples were compared. The results were the same in 83% of the samples. Discordant results were found in 10% of the samples. and in 7% additional information was achieved by one of the methods. IEF was superior to agar gel electrophoresis for the identification of oligoclonal immune reactions of the central nervous system. Tau globulin increase was seen in a few CSF samples, more often with IEF and then associated with other changes of the pattern. IEF of unconcentrated CSF followed by silver staining only requires 20 microliters CSF, while 3-4 ml CSF is needed for the agar gel electrophoretic method. It was concluded that IEF has several advantages compared to agar gel electrophoresis and is suitable as a routine method in clinical laboratories.
Synthesis and reactivity of trinuclear osmium and dinuclear and trinuclear ruthenium compounds derived from hydroxyalkynes (1981)

3-Hydroxy-3-methylbut-1-yne (HCCCMe2OH) reacts with [Ru3(CO)12] to give [Ru3H(CO)9(CCCMe2OH)] in very low yield as already described, but we can now report that the main products are isomeric compounds with empirical formula [Ru2(CO)6(alkyne)2], which contain ruthenacyclopentadiene groups, and substituted benzenes formed by oligomerisation of three alkyne molecules. Much better yields of [Os3H(CO)9(C2CMe2OH)] are obtained in a similar way with no evidence for alkyne trimerisation or complex dimer formation. The complex [Os3H2(CO)10] reacts at room temperature with HC2CMe2OH to give [Os3(CO)10(HC2CMe2OH)] and [Os3H(Co)10(CHCHCMe2OH)]. The dynamic n.m.r. behaviour of the first of these and the thermal decarbonylations of both are described. The 1H n.m.r. spectra of cationic clusters formed by hydroxide-ion loss in acidic solution are reported and the involvement of such cations in substitution and dehydration reactions of the η3 ligands.
Growth Hormone Secretagogue Peptide A233 Up-Regulates Mx Expression in Teleost Fish In Vitro and In Vivo (2021)

Abstract Aquaculture constitutes an alternative source for food production and contributes to the reduction of indiscriminate catch of aquatic organisms from their natural environment (Diaz &amp; Neira, 2005; Beveridge et al., 2013). However, high mortality during larval state remains a challenge in this sector, mainly because of factors like diets and diseases induced by pathogens (Helvik et al., 2009; Stentiford et al., 2017). Therefore, growth and health management is a key strategy for sustainable aquaculture (Martinez et al., 2016a).
Direct Observations of the Solar Wind Interaction with Jupiter (1975)

Pioneer 10 and Pioneer 11 plasma ion and electron observations in the vicinity of Jupiter are summarized. The data, obtained by the Ames Research Center Plasma Analyzer Experiments during the flybys of Jupiter in 1973 and 1974, indicate that the solar wind interaction with Jupiter (e.g., the formation of the Jovian bow shock, the magnetosheath, etc.) is basically similar to the solar wind interaction with the earth and only differs in terms of the scale size of the interaction. The plasma ion and electron measurements obtained on Pioneer 10 and Pioneer 11 are consistent with the proton measurements and indicate that the large, thick Jovian Magnetosphere which is inflated with a thermal plasma, is responsive to relatively minor changes in the solar wind dynamic pressure. The inferred motion of the Jovian bow shock and the speed at which it moved were strikingly similar during the Pioneer 10 and Pioneer 11 flybys.
Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria (2001)

We have examined IgG and complement factor C3d deposition on erythrocytes by means of the direct Coombs' test (DAT) and looked for an association with the anaemia seen in falciparum malaria in children living in an area of hyperendemic malaria transmission (in Ghana). In one study (in 1997), 53 out of 199 patients had a positive DAT. Of these, 45 samples reacted with anti-C3d antibodies, 2 with anti-IgG and 6 with both reagents. There were significantly lower haemoglobin (Hb)-levels and higher prevalence of spleen enlargement in DAT-positive than in DAT-negative patients. Hb-levels were independently associated with DAT and age. This initial study was designed to investigate the role of intravascular haemolysis (IVH), but we found no association between IVH and either DAT result or anaemia. Because of the risk of selection bias we repeated the study using consecutive enrollment of malaria patients and were able to confirm the results in a total of 49 DAT-positive and 183 DAT-negative patients. This second study (in 1998) was designed to look at the importance of erythrophagocytosis through measurement of plasma neopterin levels and total nitrite and nitrate as markers of NO-release. Both parameters were significantly higher in DAT-positive than in DAT-negative patients (P < 0.001), indicating that complement binding to erythrocytes was associated with macrophage activation. Plasma levels of haptoglobin, interleukin-10 and tumour necrosis factor-alpha did not vary between the groups. The studies support the role of complement activation and erythrophagocytosis in the pathogenesis of anaemia in falciparum malaria in African children.
The Cassini mission Ka-band TWT (2002)

A 10-watt, 32 GHz TWT is being developed and space-qualified for delivery to the Jet Propulsion Laboratory (JPL) for incorporation into the Ka-Band Transmitter Package for the Cassini Mission. The TWT program is a collaboration between NASA Lewis Research Center (LeRC), Hughes Electron Dynamics Division, and JPL. The Cassini Mission is planned for launch to the environment of Saturn in 1997. Designated Hughes 955H, the TWT has demonstrated an overall saturated efficiency in excess of 40 percent. To achieve this performance, several LeRC-developed technologies, including computer-aided advanced designs of the helix and the multistage depressed collector (MDC), along with suppression of secondary electron emission from the MDC electrodes, were used in the TWT design. An engineering model TWT and two flight model TWT's have been fabricated, packaged, and performance-tested for delivery to JPL. The production of flight hardware as a part of a program which originally was intended as a research effort has resulted in reduced overall costs and a shortened delivery schedule. This development demonstrates the value of vacuum electron devices in low-power microwave applications, frequently conceded to solid state devices in system planning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Crusade Preaching and the Ideal Crusader (2020)

Crusade preaching as a subject of historical research is thriving. For a long time, the standard resource has been Penny Cole’s The Preaching of the Crusades to the Holy Land (Cambridge [MA], 1991)...
Advanced Surface Finishes for Ceramic Electronics for Soldering, Conductive Adhesive, Aluminum- , Gold-, and Copper Wire Bonding. (2013)

Surface finishes for ceramic electronics are an important feature. . The suitable surface finish allows the appropriate assembly technology to be performed on the ceramic substrate. The paper will present the possible surface finish options for ceramic substrates and include the advantages and challenges of each surface finish. Furthermore it will show the potential of a new surface finish called “Direct EPAG”. The demand for these new finishes is based on needs for new assembly technologies like copper wire bonding and for high frequency applications. Furthermore Nickel which the main layer of many surface finishes like ENIG or ENEPIG, is more and more regarded as an unpleasant element due to several disadvantages. All these concerns are supporting the introduction of a new surface finish called “direct EPAG” (Electroless Palladium, Autocatalytic Gold) finish. In particular, its suitability for copper wire bonding and its fine line capability makes it very attractive from a cost standpoint. In addition, the mentioned technological drawbacks of nickel based finishes could be solved by applying a revolutionary surface finish: “direct palladium with an optional direct gold layer on copper”. The direct deposition of palladium on copper with an optional gold layer does have a number of technological, environmental and economic benefits. The suggested paper will describe and discuss the advantages and challenges using this new surface finish. It will also exhibit the results of various soldering and wire bond tests on the EPAG finish.
A Polymorphism in the Cytidine Deaminase Promoter Predicts Severe Capecitabine-Induced Hand-Foot Syndrome (2011)

The deleted allele of rs3215400 shows an increased allele-specific expression and is significantly associated with an increased risk of capecitabine-induced HFS.
Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)

Patients with COPD had no significant heterogeneity in airway dimensions at different anatomic locations. The airway and lung attenuation measurements of the lower lung field were more strongly correlated with airflow limitation than those of the upper lung field.