gebhart/patrepeval huggingface dataset:
Exploiting Transmission and Caching Diversity in Cache-Enabled User-Centric Network: Analysis and Optimization (2019)

User-centric network (UCN) organizes a dynamic base station group (BSG) for each user equipment (UE), consisting of potential base stations (BSs) with caching ability. However, the performance gain brought by the increased BS diversity of potential BSs has not yet been analyzed. Using stochastic geometry, the analytical expression of average outage probability is derived for the cache-enabled UCN, where a practical scenario is considered wherein inter-cache data transfer cannot be performed between BSs and the serving BS must have the requested content. Specifically, the gain of BS diversity within the BSG is characterized, where the UE benefits from transmission resource diversity of the BSG by always connecting to the BS with the best coverage performance among those with the required content, and the increased caching content diversity is utilized by searching the content within the BSG. Based on the analysis, to minimize the lower bound of outage probability, closed-form optimal caching distribution is obtained which is more uniform than the request distribution. Outage probability of the cache-enabled UCN is decreased by 42.1% compared to the case where the UE connects to the nearest BS with the required content. Moreover, the optimal caching distribution decreases outage probability by 28.5% compared to the policy of caching the most popular contents.
The mitogen‐activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1 (2016)

Arsenite is widely present in nature; therefore, cells have evolved mechanisms to prevent arsenite influx and promote efflux. In yeast (Saccharomyces cerevisiae), the aquaglyceroporin Fps1 mediates arsenite influx and efflux. The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1. In this study, we show that another MAPK, Slt2, is transiently phosphorylated in response to arsenite influx. Our findings indicate that the protein kinase activity of Slt2 is required for its role in arsenite tolerance. While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus. Our data suggest that Slt2 physically interacts with Fps1 and that this interaction depends on phosphorylation of S537. We hypothesize that Hog1 and Slt2 may affect each other's binding to Fps1, thereby controlling the opening and closing of the channel.
Fluorescence lifetime of Mn-doped ZnSe quantum dots with size dependence (2008)

Radiative lifetimes of high quality Mn:ZnSe nanocrystals synthesized by nucleation-doping method are experimentally measured at wavelength near 580nm. The slow decay rate in millisecond time scale is identified as the radiative decay from the T14 metastable excited state of Mn2+ ions embedded in the ZnSe nanocrystals. Also, two fast decay components are measured at this wavelength with much lower intensities, which can be attributed to the emission tails from the host ZnSe nanocrystals and from the surface-trap states or the self-activated luminescence due to Mn ion pairs, respectively. Size dependences of the radiative decay rates for the Mn:ZnSe samples are measured.
Targeted purification development enabled by computational biophysical modeling (2014)

Chromatographic and non-chromatographic purification of biopharmaceuticals depend on the interactions between protein molecules and a solid-liquid interface. These interactions are dominated by the protein-surface properties, which are a function of protein sequence, structure, and dynamics. In addition, protein-surface properties are critical for in vivo recognition and activation, thus, purification strategies should strive to preserve structural integrity and retain desired pharmacological efficacy. Other factors such as surface diffusion, pore diffusion, and film mass transfer can impact chromatographic separation and resin design. The key factors that impact non-chromatographic separations (e.g., solubility, ligand affinity, charges and hydrophobic clusters, and molecular dynamics) are readily amenable to computational modeling and can enhance the understanding of protein chromatographic. Previously published studies have used computational methods such as quantitative structure-activity relationship (QSAR) or quantitative structure-property relationship (QSPR) to identify and rank order affinity ligands based on their potential to effectively bind and separate a desired biopharmaceutical from host cell protein (HCP) and other impurities. The challenge in the application of such an approach is to discern key yet subtle differences in ligands and proteins that influence biologics purification. Using a relatively small molecular weight protein (insulin), this research overcame limitations of previous modeling efforts by utilizing atomic level detail for the modeling of protein-ligand interactions, effectively leveraging and extending previous research on drug target discovery. These principles were applied to the purification of different commercially available insulin variants. The ability of these computational models to correlate directionally with empirical observation is demonstrated for several insulin systems over a range of purification challenges including resolution of subtle product variants (amino acid misincorporations). Broader application of this methodology in bioprocess development may enhance and speed the development of a robust purification platform.
Questionnaire-based evaluation of everyday competence in older adults (2011)

The ECQ is a novel tool for the questionnaire-based evaluation of everyday competence among healthy subjects. By including leisure activities, it considers the changed living conditions of modern-day older adults.
Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury (2000)

We investigated the temporal and spatial expression patterns of the GDNF gene after subjecting rats to an acute contusion injury of the spinal cord using the weight drop technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that GDNF transcription in the spinal cord began to increase within 30 min after injury and peaked within 3 h. Immunohistochemical analysis showed GDNF immunoreactivity to be present mainly in microglia and macrophages 1 day after injury, but not in neurons or astrocytes. This immediate upregulation of GDNF gene expression may be a component of an inflammatory process and probably exerts a protective effect on neurons following spinal cord injury (SCI).
The Research on Collaborative Filtering Recommendation Algorithm Based on Improved Clustering Processing (2015)

In applications of personalized recommendation, user similarity of common clustering algorithms only considers user relationship without considering relationship between users and items, the similarity above reduces the accuracy of clustering, making it difficult to find similar users, and the same with item similarity. This paper improves the distance function of data clustering algorithm by Hamming distance, making accuracy of clustering much higher, so running Slope one on the processed data set above improves accuracy of recommendation significantly.
A reevaluation of the process of enucleation in mammalian erythroid cells. (1981)

In this paper, we have analysed cells which are in the process of enucleation in mouse spleen. We have provided additional support for the hypothesis that erythroid cells can autonomously undergo enucleation. The presence of a constriction in the nucleus and in the plasma membrane during this process has bee confirmed. Microfilaments have been described for the first time in the cytoplasm of maturing erythroid cells. Their position during enucleation is suggestive of an active role for these elements in this process.
Customer account management system for STEWEAG key accounts (1997)

The liberalisation (de-regulation) of the energy markets creates a new environment, with new requirements and demands on electric utilities and their business practices. STEWEAG (Austria) responded to these changes of the market by initiating an in-depth re-engineering process for the whole company in 1993. This re-engineering was mainly focused towards customer orientation, flat and flexible organisational structures, fast and correct answers to customer demands and increased transparency of processes. The customer account (billing) management system for industrial and commercial customers is to be regarded as part of this process of re-engineering.
Insect growth regulators as potential insecticides to control olive fruit fly ( Bactrocera oleae Rossi): insect toxicity bioassays and molecular docking approach (2012)

IGR molecules similar to the RH-5849 molecule, and different from methoxyfenozide and tebufenozide, might have potential in controlling this pest.
Interaction of staphylococci with bone (2009)

Staphylococci, in particular Staphylococcus aureus, are the predominant cause of bone infections worldwide. These infections are painful, debilitating and with the rise in antibiotic-resistant forms, increasingly difficult to treat. The growth in the number of prosthetic joint replacement procedures also provides new opportunities for these infections to take hold. Comprehending the mechanisms by which staphylococci interact with and damage bone is critical to the development of new approaches to meet this challenge. This review summarises current understanding of the mechanisms by which staphylococci infect and damage bone. We address the role of the inflammatory response to staphylococcal infection in disrupting the homeostatic balance of bone matrix deposition and resorption and thereby mediating bone destruction. A number of virulence factors that have been shown to contribute to bone infection and pathology are discussed, however no single factor has been defined as being specific to bone infections. Although traditionally considered an extracellular pathogen, there is increasing evidence that staphylococci are able to invade host cells, and that an intracellular lifestyle may facilitate long-term persistence in bone tissue, enabling evasion of antimicrobials and host immune responses. 'Small colony variant' strains, with mutations disabling the electron transport pathway appear particularly adept at invading and persisting within host cells, and exhibit enhanced antimicrobial resistance, and may represent a further complication in the treatment and management of staphylococcal bone disease.
Ion permeability induced in artificial membranes by the ATP/ADP antiporter (1994)

The hypothesis on the additional function of the ATP/ADP antiporter (ANT) as uncoupling protein has been tested in proteoliposomes and planar bilayer phospholipid membranes (BLM). It is found that dissipation of the light-induced delta pH in the dark is very much faster in ANT-bacteriorhodopsin proteoliposomes than in proteoliposomes containing bacteriorhodopsin as the only protein. Mersalyl treatment of ANT-bacteriorhodopsin proteoliposomes causes further increase in the delta pH dissipation rate due to formation of a high conductance pore. The properties of this pore are studied on ANT incorporated to BLM. They proved to be similar to those of so-called multiple conductance channel or permeability transition pore of inner mitochondrial membrane. The conductance of the single channel is as high as 2.2 nS. The channel fails to discriminate between K+, Na+, H+ and Cl-. Thus the obtained data are consistent with the assumption that native and modified ANT might function as an H(+)-specific conductor and as a permeability transition pore, respectively.
Electrical Properties and Applications of Carbon Nanotube Structures (2007)

The experimentally verified electrical properties of carbon nanotube structures and manifestations in related phenomena such as thermoelectricity, superconductivity, electroluminescence, and photoconductivity are reviewed. The possibility of using naturally formed complex nanotube morphologies, such as Y-junctions, for new device architectures are then considered. Technological applications of the electrical properties of nanotube derived structures in transistor applications, high frequency nanoelectronics, field emission, and biological sensing are then outlined. The review concludes with an outlook on the technological potential of nanotubes and the need for new device architectures for nanotube systems integration.
Purification and Characterization of the Polygalacturonases of Tomato Fruits (1982)

Endopolygalacturonase [poly(1,4-α-D-galacturonide) glycanohydrolase, EC 3.2.1.15] was purified from ripening tomato fruits. The dominant enzyme in fruits at an early stage of ripening had a native molecular weight (Mr) of about 115 000, an isoelectric point (pI) of 8.6, and retained 50% of activity after 10 min at 70°C. Divalent metal ions enhanced the activity of this enzyme and ethylenediaminetetraacetate (EDTA) inhibited activity. In fully ripe fruits, two enzymes of Mr about 43 000 and 46 000 were most prominent. These enzymes each had a pI of 9.4; when a mixture of these two enzymes was heated for 10 min at 50°C, 50% of activity was lost. Antibodies raised against the smallest enzyme, Mr 43 000, reacted also with the larger enzymes. After denaturation in sodium dodecyl sulfate, the largest (Mr 115 000) and smallest (Mr 43 000) enzymes yielded polypeptides of identical size while the third enzyme (Mr 46 000) was slightly larger. All three enzymes were glycoproteins. From fully ripe fruits, enzyme preparations with specific activities of 1.7 µkat mg-1 were obtained. This specific activity exceeds those described previously for plant polygalacturonases.
Mesoscopic structures in ferroelastic crystals: needle twins and right-angled domains (1996)

The shape and orientation of twin walls are calculated within the limits of elasticity theory. Single twin walls are oriented along lattice planes which are determined by the condition that the variation in the spontaneous strain through the twin walls does not generate secondary strain fields. The twin walls have a finite thickness which is described by the Landau - Ginzburg theory. Two twin walls can bend towards each other and form a wedge-shaped junction. The trajectories of the twin walls in the plane perpendicular to the junction are needle shaped so that domains enclosed by the twin walls are commonly called `needle domains'. It is shown that the actual shape of the trajectory varies widely between straight lines (i.e. planar walls near the junction) to parabolic or exponential (i.e. curved twin walls near the junction which make the needle tip appear blunt). The essential physical parameters which determine the shape of the trajectory are, firstly, the energies to bend a wall segment, secondly, the energy required to rotate a planar wall segment in an elastically anisotropic medium and, thirdly, the Peierls energy which is required to move a walls segment laterally. Various characteristic trajectories are discussed including those of junctions between orthogonal walls.
Computer-generated holograms for three-dimensional surface objects with shade and texture (2005)

Digitally synthetic holograms of surface model objects are investigated for reconstructing three-dimensional objects with shade and texture. The objects in the proposed techniques are composed of planar surfaces, and a property function defined for each surface provides shape and texture. The field emitted from each surface is independently calculated by a method based on rotational transformation of the property function by use of a fast Fourier transform (FFT) and totaled on the hologram. This technique has led to a reduction in computational cost: FFT operation is required only once for calculating a surface. In addition, another technique based on a theoretical model of the brightness of the reconstructed surfaces enables us to shade the surface of a reconstructed object as designed. Optical reconstructions of holograms synthesized by the proposed techniques are demonstrated.
UV Coatings: Basics, Recent Developments and New Applications (2008)

Chapter 1 Introduction to Coatings Technology Chapter 2 The UV Curing Process Chapter 3 Network Formation and Characterization Chapter 4 Raw Materials Chapter 5 Formulations Chapter 6 StructureProperty Relationships Chapter 7 Tackling the Drawbacks of UV Systems Chapter 8 Classical Applications Chapter 9 Recent Developments Chapter 10 New Applications Chapter 11 Health, Safety and Environment
Characterization of erythrocyte quality during the refrigerated storage of whole blood containing di-(2-ethylhexyl) phthalate (1984)

Di-(2-ethylhexyl) phthalate (DEHP) accumulates in blood brought into contact with materials utilizing this compound as a plasticizer. To determine whether this phthalate diester affects red blood cell integrity, we have compared cell morphology, plasma hemoglobin accumulation, micro-vesicle production, and the concentration of intracellular metabolites and electrolytes of erythrocytes from blood stored at 4 degrees C with and without DEHP. When sufficient emulsified DEHP was mixed with blood to give a final concentration of 300 micrograms/mL, plasma hemoglobin accumulation was reduced by an average of 70%, the percentage of cells exhibiting normal morphology was enhanced by at least 20-fold, and the volume of microvesicles released from red blood cells was reduced by 50% after 35 days of refrigerated storage compared to the values obtained from corresponding samples stored without added phthalate. Similar effects were observed regardless of whether blood was stored in nonplasticized polypropylene or tri-(2-ethylhexyl) trimellitate plasticized polyvinylchloride containers and with DEHP solubilized by a variety of emulsifiers. When 300 micrograms/mL DEHP was added to stored blood containing erythrocytes predominantly in the echinocyte conformation, many of the cells reverted to the normal discoid morphology. The addition of this quantity of DEHP to blood had no significant effect on the course of storage-induced changes in erythrocyte adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG), sodium or potassium concentrations. The data are consistent with the hypothesis that DEHP inhibits the deterioration of the red blood cell membrane that results from the refrigerated storage of whole blood.
A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors (2021)

To conclude, biodistribution of <sup>68</sup>Ga-DOTATATE was described with a whole-body PBPK model, where tissue distribution was mainly determined by variability in SSTR2 organ expression and differences in administered peptide amounts.
Central Regulation of Autonomic Functions (2011)

Central autonomic circuits in the brain and spinal cord are essential to vertebrate life: they control all basic bodily functions, including blood pressure, body temperature regulation, digestion, and reproduction. Edited by two experts in the field, Ida Llewellyn-Smith and Anthony Verberne, and extensively illustrated, the second edition of Central Regulation of Autonomic Functions presents the extraordinary advances that have been made over the last 20 years in the understanding of how the central nervous system controls autonomic functions. Written in a clear and readable manner by an international collection of neuroscientists and physiologists, and nine chapters describe central autonomic circuits from the cerebral cortex to the periphery. Eight more chapters address specific bodily functions and their control by central autonomic circuits. Two additional chapters discuss cardio-respiratory integration and regulation of autonomic function by visceral and somatic afferents. All of the chapters are up-to-date and cover topics such as the central autonomic regulation of airways, gastrointestinal function, energy homeostasis, body temperature, and sexual function, reflecting the latest research. One of the only texts to provide the whole story of how the brain controls basic bodily functions that are critical for life, Central Regulation of Autonomic Functions will be essential reading for graduate students and researchers in neuroscience, anatomy, pharmacology and physiology as well as a valuable reference work for established workers in the field.
The effect of metal clips on the tensile properties of healing skin wounds (1975)

The effects of nylon sutures and metal skin clips on the tensile properties of healing skin wounds have been studied in the pig. Wounds closed with clips have significantly poorer mechanical properties at 5, 7 and 14 days after wounding than similar wounds in the same animal closed with interrupted nylon sutures. This difference increased progressively with the period of retention of the clips. It is also shown that in equivalent groups of 14-day wounds, those in which clips were retained after the seventh day had a lower tensile strength, poorer ability to absorb energy and a lower elastic modulus than similar wounds where clips had been removed early. No such adverse effect was noted with nylon sutures.
The Viscoelastic-Plastic Displacement Back Analysis of Rock Mass with Non-Stationary Parameters (2012)

The FEM positive analysis is made using H-K non-stationary creep constitutive model in this paper, the finite element program for non-stationary viscoelastic-plastic displacement back analysis is compiled combining the non-stationary viscoelastic-plastic program with the complex shape optimization method, and the displacement back analysis of soft tunnel engineering is conducted. The result indicates that the viscous aging characteristics of rock mass can be reflected objectively if rock mass is regarded as non-stationary viscoelastic-plastic model, and the plastic zone development of surrounding rock can be predicted considering the plastic flow of rock mass and regarding the back analysis results as the calculation parameters.
Effect of omega‐3 fatty acid suplementation on Omega‐3 Index and red blood cell (RBC) membrane fatty acid composition (2008)

Omega‐3 fatty acids (n‐3 FA) have been shown from epidemiological studies and clinical trials to lower incidence of cardiovascular disease (CVD) in patients with pre‐existing CVD as well as in healthy individuals. In randomized secondary prevention trials fish or fish oil have been shown to lower total and coronary heart disease (CHD) mortality at intakes of about 1 g/day. The Omega‐3 Index (EPA + DHA expressed as % of total FA) has been proposed as a physiologically relevant, modifiable, independent and graded risk factor for death from CHD. RBC membrane FA composition correlates well with biomarkers of n‐3 FA including serum EPA and DHA, whole blood EPA, DPA and DHA and FA composition of cardiac tissue. The present dietary intervention study investigates the effect of a fish‐oil based, n‐3 FA supplement on Omega‐3 Index and RBC membrane FA composition. Thirty healthy men and women consumed a supplement providing 1070 mg total n‐3 FA (460 mg DHA, 480 mg EPA, and 80 mg other n‐3 FA) daily for 4 wks. At the end of this period there was a significant 24% increase (p&lt;0.01) in the Omega‐3 Index (Fig.1). While there were no significant changes in % linoleic, gamma linoleic, and alpha linolenic acid; EPA, DPA and DHA significantly (p&lt;0.01) increased compared to baseline values (0.76% versus 1.4%, 2.30% versus 2.58% and 5.49% versus 6.60% respectively), and % arachidonic acid significantly decreased (19.58% versus 18.83%, p&lt;0.05). This study shows that RBC membrane FA composition and so Omega‐3 Index can change in a short time using a fish‐oil based supplement.
IMPROVED PRESERVATION SOLUTIONS FOR ORGAN STORAGE (1999)

This large animal model study suggests significant improvements to human organ preservation solutions using prostacyclin analogues and adenosine with respect to hepatic bioenergetics.