gebhart/patrepeval huggingface dataset:
A FURTHER METHOD FOR PRODUCTION OF 11-KETOSTEROIDS FROM Δ7,9(11)-DIENES (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA FURTHER METHOD FOR PRODUCTION OF 11-KETOSTEROIDS FROM Δ7,9(11)-DIENESLouis F. Fieser, John C. Babcock, Josef E. Herz, Wei-Yuan Huang, and William P. SchneiderCite this: J. Am. Chem. Soc. 1951, 73, 8, 4053–4054Publication Date (Print):August 1, 1951Publication History Published online1 May 2002Published inissue 1 August 1951https://pubs.acs.org/doi/10.1021/ja01152a546https://doi.org/10.1021/ja01152a546research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Translating Biomedical Research to the Bedside (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
[Coagulation, inflammation and immune response -- an evolutionary conserved plan as cause for disseminated intravasal coagulation?]. (2005)

The concomitant activation of the immune response and the coagulation system in response to injury represents a phylogenetic old and adaptive principle already present in the early eukaryotic development. The close connection between coagulation, inflammation, and immune defense has been conserved during evolution and can still be found in humans in a number of physiologic reactions to potentially detrimental effects.
Reduced 1/f noise in p-Si0.3Ge0.7 metamorphic metal–oxide–semiconductor field-effect transistor (2004)

We have demonstrated reduced 1/f low-frequency noise in sub-μm metamorphic high Ge content p-Si0.3Ge0.7 metal–oxide–semiconductor field-effect transistors (MOSFETs) at 293 K. Three times lower normalized power spectral density (NPSD) SID/ID2 of drain current fluctuations over the 1–100 Hz range at VDS=−50 mV and VG−Vth=−1.5 V was measured for a 0.55 μm effective gate length p-Si0.3Ge0.7 MOSFET compared with a p-Si MOSFET. Performed quantitative analysis clearly demonstrates the importance of carrier number fluctuations and correlated mobility fluctuations (CMFs) components of 1/f noise for p-Si surface channel MOSFETs, and the absence of CMFs for p-Si0.3Ge0.7 buried channel MOSFETs. This explains the reduced NPSD for p-Si0.3Ge0.7 MOSFETs in strong inversion.
Effects of Age and Sex on3H-Cortisol Uptake, Binding and Metabolism in Liver and on Enzyme Induction Capacity (1971)

The effects of age and sex upon the uptake, metabolism and binding of 3H-cortisol by rat liver and on the induction of hepatic tyrosine aminotransferase were studied. The livers of fetal rats, one day before term, concentrate the hormone only 20% as well as adult livers. Fetal hepatic cytosol proteins bind only 9% as much of the injected hormone as do those from adult female rats. Hormone uptake and binding reach nearly adult levels in 24-hr-old rats. The major binding proteins are named I, II and III in the order of increasing affinity for DEAE Sephadex A-50. After fractionation of adult cytosol proteins, 3–5, 4–10 and 80–90% of the recovered cortisol radioactivity associates with Binders I, II and III, respectively. The amount of radioactivity in Binder I is constant regardless of age. However, the relative amounts of radioactivity associated with Binders II (68–73%) and III (22–28%) in fetal cytosols are reversed from the adult pattern. After 16 days, the radioactivity in Binder II begins to fall and the radioactivity in Binder III begins to rise. At 39 days, a pattern of bound radioactivity resembling that of the adult is seen. Up to 11 days after birth, hepatic tyrosine aminotransferase levels are not affected by cortisol administration. At days 15, 26 and 39, injection of cortisol (100 mg/ kg body wt) results in 2.2-, 3.1- and 5.2-fold increases in the hepatic enzyme levels. The increase in the inducibility of hepatic tyrosine aminotransferase parallels the shift in the hepatic cortisol metabolite binding from the fetal to the adult pattern. Adult male rats metabolize cortisol to produce a small amount of a non-anionic compound (A) and larger amounts of 3 anionic derivatives B, C and D (in order of increasing negative charge). Adult female liver forms only C. Fetal rats do not produce these metabolites to any great extent. Over 90% of the radioactivity from fetal liver is comprised of cortisol and tetrahydrocortisol. Within 4 days after birth, rats start to produce metabolite C. Metabolites B and D appear only in male rats 32 days of age or older. (Endocrinology88: 1448, 1971)
Integration of Plug-In Hybrid Electric Vehicles into energy networks (2009)

Electrification of substantial percentages of individual transportation through Plug-In Hybrid Electric Vehicles (PHEVs) will lead to an integration of power and transport systems. This, in turn, will impose an additional demand on today's power system, potentially stressing hazardous for some pieces of equipment. Smart management schemes, investigated in this paper, can alleviate possible congestion issues in power systems by intelligently distributing available energy among connected PHEVs, modelled as agents with individual parameters and goals. The management scheme is integrated in aggregation entities, clustering PHEVs in various urban areas. Network impacts resulting from the smart management scheme will be studied based on power flow calculations. The analysis will give implications for PHEV integration schemes as well as tentative ideas of possible repercussions on hybrid power systems and how to counteract.
Efficiency of puromycin-based technologies mediated by release factors and a ribosome recycling factor (2013)

Two puromycin-based techniques, in vitro virus (IVV) and C-terminal labelling of proteins, were developed based on the observation that puromycin binds the C-terminus of a protein. Puromycin technology is a useful tool for the detection of proteins and analysis of protein-protein interactions (PPIs); however, problems arise due to the existence of stop codons in the native mRNAs. Release factors (RFs) that enter the A-site of the ribosome at stop codons compete with puromycin. To overcome this issue, we have used a highly controllable reconstituted cell-free system for puromycin-based techniques, and observed efficient IVV formation and C-terminal labelling using templates possessing a stop codon. The optimal conditions of IVV formation using templates possessing a stop codon was RF (-), while that of C-terminal labelling was RF (-) and the ribosome recycling factor (RRF) (+). Thus, we have overcome the experimental limitations of conventional IVV. In addition, we discovered that RRF significantly increases the efficiency of C-terminal protein labelling, but not IVV formation.
Vasospasm probability index: a combination of transcranial Doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage (2007)

Object The goal in this study was to create an index (vasospasm probability index [VPI]) to improve diagnostic accuracy for vasospasm after subarachnoid hemorrhage (SAH). Methods Seven hundred ninety-five patients in whom aneurysmal SAH was demonstrated by computed tomography, and in whom one or more intracranial aneurysms had been diagnosed, underwent transcranial Doppler (TCD) studies between April 1998 and January 2000. In 154 patients angiography was performed within 24 hours of the TCD examination, and in 75 133Xe cerebral blood flow (CBF) studies were obtained the same day. Seven cases were excluded because of a limited sonographic window. Forty-one women (60.3%) and 27 men (39.7%) between the ages of 35 and 84 years (58.0 ± 13.2 years [mean ± standard deviation]) were included. Clinical characteristics analyzed included age, sex, Hunt and Hess grade, Fisher grade, days after SAH, day of treatment, type of treatment (coil embolization, surgical clip occlusion, or conservative treatment), smoking history, and hypertension history. Lindegaard ratios and spasm indexes (TCD velocities/hemispheric CBF) were calculated bilaterally. Digital subtraction angiography images were measured at specific points of interest. Sensitivity, specificity, predictive values, and global accuracy of the different tests were calculated. Logistic regression was used to evaluate the possible predictive factors, and the coefficients of the logistic regression were integrated to create the VPI. Results In 18 patients (26.5%) symptomatic vasospasm was diagnosed, and 33 (48.5%) had angiographic evidence of vasospasm. For TCD velocities above 120 cm/second at the middle cerebral artery, the global accuracy was 81.1% for the diagnosis of clinical vasospasm and 77.2% for angiographic vasospasm. For a Lindegaard ratio higher than 3.0, the accuracy was 85% for clinical vasospasm and 83.2% for angiographic vasospasm. A spasm index higher than 3.5 had an accuracy of 82.0% for the diagnosis of clinical vasospasm and 81.6% for angiographic vasospasm. The selected model for estimation of clinical vasospasm included Fisher grade, Hunt and Hess grade, and spasm index. The VPI had a global accuracy of 92.9% for clinical vasospasm detection. For diagnosis of angiographic vasospasm, the model included Fisher grade, Hunt and Hess grade, and Lindegaard ratio. The VPI achieved a global accuracy of 89.9% for angiographic vasospasm detection. Conclusions The use of TCD velocities, Lindegaard ratio, and spasm index independently is of limited value for the diagnosis of clinical and angiographic vasospasm. The combination of predictive factors associated with the development of vasospasm in the new index reported here has a significantly superior accuracy compared with the independent tests and may become a valuable tool for the clinician to evaluate the individual probability of cerebral vasospasm after aneurysmal SAH.
Optimizing complex queries with multiple relation instances (2008)

Today's query processing engines do not take advantage of the multiple occurrences of a relation in a query to improve performance. Instead, each instance is treated as a distinct relation and has its own independent table access method. In this paper, we present MAPLE, a Multi-instance-Aware PLan Evaluation engine that enables multiple instances of a relation to share one physical scan (called SharedScan) with limited buffer space. During execution, as SharedScan pulls a tuple for any instance, that tuple is also pushed to the buffers of other instances with matching predicates. To avoid buffer overflow, a novel interleaved execution strategy is proposed: whenever an instance's buffer becomes full, the execution is temporarily switched to a drainer (an ancestor blocking operator of the instance) to consume all the tuples in the buffer. Thus, the execution is interleaved between normal processing and drainers. We also propose a cost-based approach to generate a plan to maximize the shared scan benefit as well as to avoid interleaved execution deadlocks. MAPLE is light-weight and can be easily integrated into existing RDBMS executors. We have implemented MAPLE in PostgreSQL, and our experimental study on the TPC-DS benchmark shows significant reduction in execution time.
High-power cw bismuth-fiber lasers (2007)

Continuous-wave lasing of Bi-doped fiber lasers in a wavelength range of 1150-1215 nm with a power of up to 15 W has been obtained for the first time. The unsaturable optical losses in Bi-doped fibers have been revealed and their influence on the Bi-laser operation is investigated. Frequency doubling of the Bi-fiber laser radiation is demonstrated that can be used as a yellow light source (wavelength of 580 nm).
A System for Making and Deploying Oxide‐Coated Plastic Films for Environmental Assessment of Soils (2018)

Core Ideas IRIS films document reducing soil conditions. IRIS films perform the same as IRIS tubes. IRIS films permit easy acquisition of two‐dimensional images. The IRIS film deployment system protects IRIS from abrasion or scratching. IRIS films require 5% of the storage volume of traditional IRIS tubes. The documentation of reducing conditions in soils is important in the study, monitoring, and delineation of hydric soils and wetlands. Over the last decade, IRIS (Indicator of Reduction In Soils) technology has moved from the periphery into common use in hydric soils studies. Their appeal has been their ease of use and their conceptual simplicity, and IRIS technology has been approved by the US National Technical Committee for Hydric Soils (NTCHS). Recent developments in IRIS applications have also utilized Mn oxide paint, in addition to Fe oxide paint. While IRIS technology has encompassed a variety of forms, polyvinyl chloride (PVC) tubes are used most commonly. There are, however, challenges when using traditional PVC IRIS tubes. These include: (1) difficulty in acquiring a two‐dimensional image from a three‐dimensional cylindrical structure; (2) abrasion or scratching of the tubes during transport and on insertion (especially in sandy or dense soil conditions); (3) expense of shipping due to their weight and size; (4) long term storage issues; (5) general environmental and/or sustainability concerns with using non‐reusable plastic tubing. This paper describes a system for the delivery and installation of oxide‐coated plastic films in soils. Field testing of both Fe‐coated and Mn‐coated devices demonstrates that data provided by films does not differ significantly from data provided by tubes. However, many of the problems and issues that have plagued the use of IRIS tubes are eliminated by use of IRIS films.
Learning Neural Representations of Human Cognition across Many fMRI Studies (2017)

Cognitive neuroscience is enjoying rapid increase in extensive public brain-imaging datasets. It opens the door to large-scale statistical models. Finding a unified perspective for all available data calls for scalable and automated solutions to an old challenge: how to aggregate heterogeneous information on brain function into a universal cognitive system that relates mental operations/cognitive processes/psychological tasks to brain networks? We cast this challenge in a machine-learning approach to predict conditions from statistical brain maps across different studies. For this, we leverage multi-task learning and multi-scale dimension reduction to learn low-dimensional representations of brain images that carry cognitive information and can be robustly associated with psychological stimuli. Our multi-dataset classification model achieves the best prediction performance on several large reference datasets, compared to models without cognitive-aware low-dimension representations, it brings a substantial performance boost to the analysis of small datasets, and can be introspected to identify universal template cognitive concepts.
Patterns of Innervation of the Anterior Maxilla: A Cadaver Study with Relevance to Canine Fossa Puncture of the Maxillary Sinus (2005)

There is significant variation in the pattern of ASAN and MSAN within the anterior face of the maxilla. By using the newly described landmarks when performing a canine fossa puncture, there is reduced risk of damage to these nerves and provides a reliable point to enter the maxillary sinus.
Radiation Pressure, Drag in Poynting-Robertson Drag, and the Restricted Three-Body Problem (1995)

In this paper, we examine the effects of radiation pressure, Poynting-Robertson (PR) drag, and solar wind drag on dust grains trapped in mean motion resonances with the Sun and Jupiter in the restricted (negligible dust mass) three-body problem. We especially examine the evolution of dust grains in the 1:1 resonance. As a first step, the Sun and Jupiter are idealized to both be in circular orbit about a common center of mass (circular restricted three-body problem). From the equation of motion of the dust particle in the rotating reference frame, the drag-induced time rate of change of its Jacobi constant, C, is then derived and expressed in spherical coordinates. This new mathematical expression in spherical coordinates shows that C, in the 1:1 resonance, both oscillates and secularly increases with increasing time. The new expression gives rise to an easy understanding of how an orbit evolves when the radiation force and solar wind drag are included. All dust grain orbits are unstable in time when PR and solar wind drag are included in the Sun-Jupiter-dust system. Tadpole orbits evolve into horseshoe orbits; and these orbits continuously expand in size to lead to close encounters with Jupiter. Permanent trapping is impossible. Orbital evolutions of a dust grain trapped in the 1 : 1 resonance in the planar circular, an inclined case, an eccentric case, and the actual Sun-Jupiter case are numerically simulated and compared with each other and show grossly similar time behavior. Resonances other than 1:1 are also explored with the new expression. Stable exterior resonance trapping may be possible under certain conditions. One necessary condition for such a trap is derived. Trapping in interior resonances is shown to be always unstable. © ,_sAcidic P_, i_.
On Quadratic Differential Metrics on a Closed Riemann Surface (2014)

We study properties of the space of quadratic differ- ential metrics on a closed Riemann surface of genus g ≥ 2. First, we introduce a natural metric on this space defined via length distortions which is proper and compact. Second, we study topological properties of this space and show equivalence of various convergences. Besides, we relate the preceding metric to another metric which is obtained via global Lipschitz constants. In this paper, we study properties of the space of quadratic differential metrics on a closed Riemann surface of genus g ≥ 2. Let X be a closed Riemann surface of genus g ≥ 2. Let Q(X) be the Banach space of holo- morphic quadratic differentials on X endowed with the L1-norm || ·| |1, and Q1(X) the unit sphere in Q(X). It is well-known that ((6, 8)) Q(X) can be viewed as the cotangent space to the Teichmuller space T (X )a tX. Each non-zero q ∈ Q(X) induces ((19)) a metric |q| on X known as a quadratic differential metric or q-metric. These metrics are complete geodesic metrics and have been studied extensively. The importance of such metrics lies in many aspects, e.g., they serve as ((7, 19)) extremal metrics in the defini- tion of extremal lengths. Let |Q(X)| = {|q| : q ∈ Q(X)} be the space of quadratic differential metrics on X. For a non-zero q, to each homotopy class of a closed curve α one associates its q-length lq(α) (see Section 2 for details). In this paper, we will study properties of |Q(X)| in terms of the length functions lq(α).
Integrating molecular knowledge in clinical decision-making for personalized cancer management: A user-friendly handbook for physicians, biologists and patients (2012)

He is involved in application of translational genetic research to the clinical setting and has implemented large-scale screening for EGFR mutations in lung cancer
Densification of Al 2 O 3 ‐SiO 2 ‐TiO 2 ‐Based Ceramic Coating Film by Grain Size Control (2006)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusion
Cover crops in the upper midwestern United States: Simulated effect on nitrate leaching with artificial drainage (2014)

A fall-planted winter cover crop is an agricultural management practice with multiple benefits that may include reducing nitrate (NO<sub>3</sub>) losses from artificial drained agricultural fields. While the practice is commonly used in the southern and eastern United States, little is known about its efficacy in midwestern states where winters are longer and colder, and artificial subsurface drainage is widely used in corn–soybean systems (<i>Zea mays</i> L.–<i>Glycine max</i> L.). We used a field-tested version of the Root Zone Water Quality Model (RZWQM) to simulate the adoption of cereal rye (<i>Secale cereale</i> L.) as a winter cover crop and estimate its impact on NO<sub>3</sub> losses from drained fields at 41 sites across the Midwest from 1961 to 2005. The average annual nitrogen (N) loss reduction from adding winter rye ranged from 11.7 to 31.8 kg N ha<sup>−1</sup> (10.4 to 28.4 lb N ac<sup>−1</sup>) among four simulated systems. One of the simulated treatments was winter rye overseeded (aerial seeded) into a no-till corn–soybean rotation at simulated main crop maturity (CC2). On average, this treatment reduced simulated N loss in drainage by 20.1 kg N ha<sup>−1</sup> (17.9 lb N ac<sup>−1</sup>) over the sites compared to systems without winter rye (NCC2), from 47.3 to 27.2 kg N ha<sup>−1</sup> (42.2 to 24.3 lb N ac<sup>−1</sup>). Adding spring tillage to this treatment and killing the rye earlier (CC3) reduced simulated N loss from 57.3 (NCC3) to 34.4 kg N ha<sup>−1</sup> (30.7 lb N ac<sup>−1</sup>). Replacing the corn–soybean rotation with continuous corn and spring tillage reduced simulated N loss from 106 (NCC4) to 74.2 kg N ha<sup>−1</sup> (CC4) (94.6 to 66.2 lb N ac<sup>−1</sup>). Adding a winter rye cover crop reduced N loss more in the continuous corn system despite earlier spring termination of the winter rye and slightly less N uptake by the rye possibly because of more denitrification. Regression analysis of the RZWQM variables from these sites showed that temperature and precipitation during winter rye growth, N fertilizer application rates to corn, and simulated corn yield account for greater than 95% of the simulated site-to-site variability in NO<sub>3</sub> loss reductions in tile flow due to winter rye. Our results suggest that on average winter rye can reduce N loss in drainage 42.5% across the Midwest. Greater N loss reductions were estimated from adding winter rye at sites with warmer temperatures and less precipitation because of more cover crop growth and more soil N available for cover crop uptake.