gebhart/patrepeval huggingface dataset:
Substituted Polyesters by Thiol–Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization (2017)

Many proteins, especially those used as therapeutics, are unstable to storage and shipping temperatures, leading to increased costs in research and industry. Therefore, the design and synthesis of novel stabilizers is an important area of investigation. Herein we report new degradable polymers that stabilize proteins to environmental stressors such as refrigeration and elevated temperature. Specifically, polycaprolactones with different pendant groups were synthesized and surveyed for their ability to stabilize an important therapeutic protein to storage and shipping conditions. Ring-opening polymerization (ROP) of an allyl-substituted caprolactone monomer was carried out using the organocatalyst 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to yield a well-defined, alkene-substituted degradable polymer, which was used as a common backbone to control for the degree of polymerization. Relevant side chains such as trehalose, lactose, glucose, carboxybetaine, and oligo(ethylene glycol) were installed via postpolymerization thiol-ene reactions. These degradable polymers were then employed as excipients for the stabilization of the therapeutic protein granulocyte colony-stimulating factor (G-CSF) against storage at 4 °C and shipping temperatures of 60 °C. The best stabilization was observed using the trehalose- and zwitterion- substituted polyesters. Both the trehalose- and carboxybetaine-substituted pCL were further investigated with regard to molecular weight dependence, and it was found that the molecular weight was minimally important for stabilization to refrigeration, but critical for G-CSF stabilization at elevated temperatures. Both high performing zwitterionic and trehalose polyesters were also degraded, and the polymers and degradation products were shown to be noncytotoxic. This work provides potential biocompatible polymers for stabilization of the important therapeutic G-CSF, as well as a general platform for the future discovery of new polymeric protein stabilizers.
Vitamin A, nutrition, and health values of algae: Spirulina, Chlorella, and Dunaliella (2011)

Spirulina, chlorella, and dunalliella are unicellular algae that are commercially produced worldwide. These algae are concentrated sources of carotenoids (especially provitamin A carotenoids) and other nutrients, such as vitamin B12. Their health benefits as a complementary dietary source for macro and micro nutrients have been studied and confirmed in various populations. The safety of human consuming these algae and products derived from these algae by humans has been widely studied. It is generally concluded that these algae and its products are safe if cultivated properly in a non-contaminated environment, and if consumed in moderation.
Damage Monitoring for Semi-Transparent Composites Using Luminance of EL Backlight. (2000)

The present paper a new damage monitoring system that employs luminance of EL backlight for semi-transparent composites. For the semi-transparent composites, damage is easily found by visual inspections. In the cases that the structures are sealed or huge structures, however, the visual inspections are difficult. The present paper adopts a system using change of luminance of transmitted light. When the composite structures are damaged, the damage reduces luminance of the transmitted light from the backside. The present study adopts an Electro Luminescent device (EL) as the backlight. The EL device can emit uniform-plane-light and is a very flexible device. The EL device can be mounted on a curved surface. Fatigue tests are conducted using rectangular specimens with an open hole fabricated from fabric glass/epoxy composites. The monitoring system is applied to the fatigue tests, and it is experimentally shown that the method can detect the fatigue damage without loading.
It is with great pleasure that we present to you the 1991 Swine Day Report. This report contains summaries of applied and basic swine research conducted at Kansas State University during the past year. Topics range from economics to meats, and physiology to nutrition. We hope that the information will be of benefit, as we attempt to meet the needs of the Kansas swine industry. Editors, 1991 Swine Day Report, (1991)

ABBREVIATIONS USED IN THIS REPORT avg = average BW = body weight cm = centimeter(s) CP = crude protein cwt = 100 lb d = day(s) DM = dry matter = Fahrenheit ft = foot(feet) ft = square foot(feet) 2 g = gram(s) gal = gallon(s) h = hour(s) in. = inch(es) IU = international unit(s) kg = kilogram(s) Kcal = kilocalorie(s) lb = pound(s) Mcal = megacalorie(s) mEq = milliequivalent(s) min = minute(s) mg = milligram(s) ml = cc (cubic centimeters) mo = month(s) = microgram(s) = .001 mg N = nitrogen ng = nanogram(s) = .001 no. = number ppm = parts per million sec = second(s) wk = week(s) wt = weight(s) yr = year(s)
Enhancing enterprise field productivity via cross platform mobile cloud apps (2011)

This paper describes the design, implementation, deployment, and ongoing management of a cross-platform native mobile application that empowers the Field (Sales, Marketing, Systems Engineers) in an Enterprise to collaborate with Customers through sharing "the right enterprise content & services: anytime, anywhere, from many mobile devices". The mobile application is designed as a thin smart phone native client that assumes its (a) User Interface as well as (b) Productivity enhancing Content & Services, from a cloud service. The cloud service provides enterprise-grade capabilities including (a) enterprise authentication & role-based access control (b) connectors for enterprise backend services such as Customer Relationship Management (CRM), Sales Force Automation (SFA), Content Management, Knowledge Bases, Ordering, and Pricing and (c) global scalability and high availability. A single application specification hosted on the cloud drives a consistent use interface and user experience across multiple mobile devices including Android, Blackberry and IOS. We describe, one active production use of this application by thousands of Cisco's Worldwide Field users, live for almost a year, and used in 54 countries. We describe the technical challenges, business use cases, usage tracking, and real world experience gained over the course of this duration.
Synthesis and Characterisation of Two Supramolecular Polymers [CuAg4(CN)6(tacn)]n and [CuAu2(CN)4(tacn)]n Containing Metal−Metal Interactions (2004)

Abstract Two novel heterobimetallic supramolecular polymers, [CuAg 4 (CN) 6 (tacn)] n ( 1 ) and [CuAu 2 (CN) 4 (tacn)] n ( 2 ) (tacn = 1,4,7‐triazacyclononane), have been synthesised from the building block [Cu(tacn)] 2+ , together with [Ag(CN) 2 ] − (for 1 ) and [Au(CN) 2 ] − (for 2 ). The large difference in structural type between 1 and 2 is probably due to the fact that the Ag I centre is three‐coordinate and trigonal whereas the Au I centre is linear. Metal−metal interactions play an important role in the formation of the supramolecular framework of 1 and the novel topology of 2 . (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Maximum Likelihood Identification of a Posture Control System (1987)

To identify characteristics of a sensory feedback path of a posture control system without external disturbances, the maximum likelihood identification method was applied to data of an antero-posterior sway during quiet stance. A subject stood on a force plate and the sway angle of a body (input) was measured by a position sensor camera and the ankle joint moment (output) was measured by the force plate. Using data of 500 input-output pairs sampled every 0.1 s, parameters of the sensory feedback path were estimated and frequency response functions were calculated. These showed derivative characteristics that are necessary for stabilization of the posture control system. Gain characteristics under the closed eyes condition tended to be greater than those under the open eyes condition.
Developments in Hybrid Si – SiC Power Modules (2006)

This paper investigates utilization of silicon carbide (SiC) Schottky power diodes as inverter Free Wheel Diodes (FWD) in a commercially available standard Econopak module also packaged with latest generation low-loss IGBT silicon. Static and switching characteristics of SiC diodes over standard module operating temperature 25 0C to 125 0C (298 0K - 398 0K) are measured. Module Turn-on, Turn-off and conduction losses vs. frequency are calculated and measured for three phase motor drive operation. Measurements are compared to standard modules using all Silicon (Si) IGBT- diode. System benefits justifying the increased SiC diode cost, such as EMI reduction, increased efficiency, reduced magnetic filter volume and reduced cooling requirements at higher allowable switching frequencies is investigated.
Expression and epitopic conservation of calponin in different smooth muscles and during development (1996)

Calponin is a thin filament associated protein found in smooth muscle as a potential modulator of contraction. Five mouse monoclonal antibodies (mAbs CP1, CP3, CP4, CP7, and CP8) were prepared against chicken gizzard alpha-calponin. The CP1 epitopic structure is conserved in smooth muscles across vertebrate phyla and is highly sensitive to CNBr cleavage in contrast with the chicken-specific CP4 and the avian-mammalian-specific CP8 epitopes that are resistant to CNBr fragmentation. Using this panel of mAbs against multiple epitopes, only alpha-calponin was detected in adult chicken smooth muscles and throughout development of the gizzard. Western blotting showed that the calponin content varied among different smooth muscle tissues and correlated with that of h-caldesmon. In contrast with the constitutive expression of calponin in phasic smooth muscle of the digestive tract, very low levels of calponin were detected in adult avian tracheas and no calponin expression was detected in embryonic and young chick tracheas. These results provide information on the structural conservation of calponins and suggest a relationship between calponin expression and smooth muscle functional states.
Sound transmission between 50 and 600 Hz in excised pig lungs filled with air and helium (2000)

This study measured transit time (TT) and attenuation of sound transmitted through six pairs of excised pig lungs. Single-frequency sounds (50-600 Hz) were applied to the tracheal lumen, and the transmitted signals were monitored on the tracheal and lung surface using microphones. The effect of varying intrapulmonary pressure (Pip) between 5 and 25 cmH(2)O on TT and sound attenuation was studied using both air and helium (He) to inflate the lungs. From 50 to approximately 200 Hz, TT decreased from 4.5 ms at 50 Hz to 1 ms at 200 Hz (at 25 cmH(2)O). Between approximately 200 and 600 Hz, TT was relatively constant (1.1 ms at upper and 1.5 ms at lower sites). Gas density had very little effect on TT (air-to-He ratio of approximately 1.2 at upper sites and approximately 1 at lower sites at 25 cmH(2)O). Pip had marked effects (depending on gas and site) on TT between 50 and 200 Hz but no effect at higher frequencies. Attenuation was frequency dependent between 50 and 600 Hz, varying between -10 and -35 dB with air and -2 and -28 dB with He. Pip also had strong influence on attenuation, with a maximum sensitivity of 1.14 (air) and 0.64 dB/cmH(2)O (He) at 200 Hz. At 25 cmH(2)O and 200 Hz, attenuation with air was about three times higher than with He. This suggests that sound transmission through lungs may not be dominated by parenchyma but by the airways. The linear relationship between increasing Pip and increasing attenuation, which was found to be between 50 and approximately 100 Hz, was inverted above approximately 100 Hz. We suggest that this change is due to the transition of the parenchymal model from open to closed cell. These results indicate that acoustic propagation characteristics are a function of the density of the transmission media and, hence, may be used to locate collapsed lung tissue noninvasively.
The interaction of buthionine sulphoximide (BSO) and the topoisomerase I inhibitor CPT-11. (1996)

Buthionine sulphoximide (BSO)-induced depletion of glutathione (GSH) was found to be associated with an increased sensitivity to CPT-11 (topoisomerase I-reactive agent) in V79 hamster lung fibroblast cells. When V79 cells were exposed to 2.5 mM BSO for 28 h beginning 4 h prior to a 24 h coincubation with CPT-11, cytotoxicity was increased compared with CPT-11 alone. It was determined that BSO resulted in a G1 cell cycle arrest and a decrease in the percentage of cells in S-phase. Since CPT-11 is known to be S-phase-specific, this BSO-induced cell cycle redistribution did not appear to account for the chemosensitisation of CPT-11. Additionally, BSO did not alter intracellular accumulation of CPT-11, conversion of CPT-11 to its active metabolite SN-38, or efflux of either CPT-11 or SN-38 from the cell. Finally, BSO resulted in a slight reduction, rather than an increase, in the number of stabilised DNA-topoisomerase I complexes induced by CPT-11. Therefore, these results suggest that BSO-induced sensitisation of V79 cells to the cytotoxic effects of CPT-11 occurs by a mechanism independent of the stabilisation of DNA-topoisomerase I complexes.
Solvolysis of iodopentaaquachromium(III) ion in acidic aqueous dimethyl sulfoxide (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvolysis of iodopentaaquachromium(III) ion in acidic aqueous dimethyl sulfoxideDennis B. Vanderheiden and Edward L. KingCite this: J. Am. Chem. Soc. 1973, 95, 12, 3860–3866Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://doi.org/10.1021/ja00793a007RIGHTS & PERMISSIONSArticle Views48Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (968 KB) Get e-Alerts Get e-Alerts
Detection of antibodies to the benzo(a)pyrene diol epoxide-DNA adducts in sera from individuals exposed to low doses of polycyclic aromatic hydrocarbons. (2001)

The exposure to DNA reactive carcinogens is known to elicit a specific humoral immunological response, with the production of antibodies toward the carcinogen adducts. Consequently, the presence of circulating anti-carcinogen antibodies has been proposed as a marker of carcinogen exposure, and as a potential modulating factor in chemical carcinogenesis. In this work, the presence of serum antibodies to 7beta,8alpha-dihydroxy-9alpha10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-DNA (BPDE-DNA) adducts was determined in two groups of workers occupationally exposed to low doses of polycyclic aromatic hydrocarbons (PAHs), i.e. policemen (194 subjects) and workers in the aluminum industry (105 subjects). Specific anti BPDE-DNA antibodies were detected in 5.7% (11/194) of policemen and 13.3% (14/105) of aluminium industry workers. Among policemen, a small, not significant (p=0.09), prevalence of positives was observed in traffic wardens compared to office workers. A borderline significant (p=0.052) prevalence of positives was also observed in heavy smokers compared to light smokers among aluminium industry workers. These results basically support previous findings on the association between chronic exposure to polycyclic aromatic hydrocarbons and formation of anti-BPDE-DNA antibodies, even though such association appears to be weak, possibly biased by individual factors which are still largely unidentified.
Enantioselective Intramolecular Aldol Addition/Dehydration Reaction of a Macrocyclic Diketone: Synthesis of the Musk Odorants (R)‐Muscone and (R,Z)‐5‐Muscenone (2007)

One hundred years after the first isolation of natural (R)-muscone [(R)-1], a short and efficient access to the outstanding odorants (R)-1 and (R,Z)-5-muscenone [(R)-2] has become possible thanks to an unprecedented, reversible intramolecular aldol addition/enantioselective dehydration (up to 76 % ee; see scheme).
Development of an Error-Correction Method for Data Packet Multiplexed with TV Signals (1987)

By using the vertical blanking period of television signals, it is possible to transmit coded data such as teletext, telesoftware, music, etc. However, the quality of data transmission on television transmission channels is very poor and a powerful error-correction code is required to reliably transmit coded data. From the results of simulations using error pattern data collected in field tests and the comparison of various error-correction codes under many conditions, it has been determined that the shortened (272, 190) majority-logic decodable difference-set cyclic code is a suitable code for NTSC TV signals. By using error-correction codes proposed to date for teletext, it has been difficult to obtain a page error rate (PER) of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> in many measurement points. However, PER's of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> can be obtained in this system, even when random noise, ghost interference, or waveform distortion are present and bit error rates (BER's) are 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . This paper also gives an empirical equation according to the error data and shows that the error-correction capability increased equivalently up to 11 error-bits in a packet by modifying the decoding algorithm.
Low degradation and fast annealing effects of amorphous silicon multilayer processed through alternate hydrogen dilution (2000)

Alternately hydrogen diluted a-Si:H multilayers are shown to be a promising concept for the fabrication of stable a-Si:H solar cells or other a-Si:H based devices. The alternately hydrogen diluted amorphous silicon multilayers were obtained by toggling both the H2/SiH4 dilution ratio and the total flow rate of the gases under continuous UV light irradiation into the reaction chamber of a photochemical vapor deposition system. The films were characterized by Fourier transformed infrared spectroscopy, spectroscopic ellipsometry, cross-sectional transmission electron microscopy, and atomic force microscopy. We applied these multilayers as the active layer of p–i–n type thin film solar cells. The multilayer solar cells are compared to solar cells incorporating a-Si:H made from pure SiH4 gas and to solar cells incorporating a-Si:H made at a constant hydrogen dilution ratio containing nearly the same hydrogen amount as the multilayer. We report on the light-soaking and annealing behavior of the solar cells. The multilayer solar cell has an exceptionally high recovery rate at low temperatures, which makes the solar cell degradation behavior highly sensitive to the cell temperature during degradation. Following the relation, DH∝1/τ, where DH and τ are the diffusion coefficient for hydrogen and time constant for annealing, respectively, the layered structure in the multilayer possibly elevates DH, which accounts for rapid stabilization and annealing.
Combining Catalyzed Reporter Deposition-Fluorescence In Situ Hybridization and Microautoradiography To Detect Substrate Utilization by Bacteria and Archaea in the Deep Ocean (2004)

The recently developed CARD-FISH protocol was refined for the detection of marine Archaea by replacing the lysozyme permeabilization treatment with proteinase K. This modification resulted in about twofold-higher detection rates for Archaea in deep waters. Using this method in combination with microautoradiography, we found that Archaea are more abundant than Bacteria (42% versus 32% of 4',6'-diamidino-2-phenylindole counts) in the deep waters of the North Atlantic and that a larger fraction of Archaea than of Bacteria takes up l-aspartic acid (19% versus 10%).
Exposure to Heptachlorodibenzo-p-dioxin (HpCDD) Regulates microRNA Expression in Human Lung Fibroblasts (2019)

These studies reveal that miRNAs previously identified in sera from personnel deployed to sites with open burn pits are altered by HpCDD exposure in HLFs.
ISP 47 ''containment thermal-hydraulics'' computer codes exercise based on TOSQAN, MISTRA and THAI experiments (2002)

International consensus is that a detailed knowledge of containment thermal-hydraulics is necessary to predict the local distribution of hydrogen, steam and air inside the containment under representative conditions of severe accident. Looking back at the ISPs that have been reviewed in the SOAR, it becomes all too apparent that every ISP has involved a rather complicated integral test and that there has been a lack of separate phenomena testing within the ISP framework. The main objective of the ISP-47 is to demonstrate the actual capability of CFD and 'lumped parameter' codes in the field of containment thermal-hydraulics, e.g. to predict the hydrogen distribution under LOCA conditions. The proposed activities will lead to a significant improvement of the reliability of severe accident containment models/codes. As recommended in the SOAR this approach follows a strategy being progressive in modelling difficulty and it is proposed to realize this ISP in two main steps, the first one is dedicated to the validation of refined models in the separate effect facility TOSQAN (7 m{sup 3}) and at larger scale in MISTRA (100 m{sup 3}) and the second one addresses the validation of codes in a complex and more realistic compartmented geometry ThAI (60 m{sup 3}). Descriptions of the three experiments on which the ISP is based and the presentation of the specific test selected for the ISP are given. (orig.)
Effects of loperamide‐oxide on fentanyl drug discrimination in rats (1988)

Abstract The effects of loperamide and loperamide‐oxide were studied in rats trained to discriminate 0.04 mg/kg, fentanyl from saline. After oral pretreatment with the doses of 0.63, 2.50, 10.0, and 40.0 mg/kg, neither loperamide nor loperamide‐oxide produced any generalization with fentanyl. Both compounds depressed the response rate at 10 and 40 mg/kg. These results indicate that loperamide and loperamide‐oxide produce no fentanyl generalization in rats up to doses at least 250 times their antidiarrheal dose and that both drugs are expected to be devoid of an opiate‐like addiction liability in man.
Corrigendum: Heterogeneous Catalytic Hydrogenation of Biobased Levulinic and Succinic Acids in Aqueous Solutions (2013)

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