gebhart/patrepeval huggingface dataset:
Machine Learning Reactivity in the Chemical Space Surrounding Vaska's Complex (2019)

Machine learning models, including neural networks, Bayesian optimization, gradient boosting and Gaussian processes, were trained with DFT data for the accurate, affordable and explainable prediction of hydrogen activation barriers in the chemical space surrounding Vaska's complex.
Report of Subcommittee G on Recommendation for Official Methods (1974)

Journal Article Report of Subcommittee G on Recommendation for Official Methods Get access Maynard J Pro, Maynard J Pro Chairman Bureau of Alcohol, Tobacco and Firearms, Department of the Treasury, Washington, D.C. 20224 Search for other works by this author on: Oxford Academic Google Scholar Chester A Luhman, Chester A Luhman Feed Laboratory, State Department of Agriculture, Sacramento, Calif. 95814 Search for other works by this author on: Oxford Academic Google Scholar Alfred Weissler, Alfred Weissler Division of Color Technology, Food and Drug Administration, Washington, D.C. 20204 Search for other works by this author on: Oxford Academic Google Scholar William W Wright William W Wright Secretary Office of Pharmaceutical Research and Testing, Food and Drug Administration, Washington, D.C. 20204 Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Analytical Chemists, Volume 57, Issue 2, 1 March 1974, Pages 441–443, https://doi.org/10.1093/jaoac/57.2.441 Published: 13 February 2020
P6590Androgenic effects on ventricular repolarization: a translational study from pharmacovigilance databases to iPSC-cardiomyocytes (2019)

Abstract Aim Male hypogonadism, arising from various etiologies including androgen-deprivation therapies (ADT), has been reported as a risk-factor for acquired long-QT (aLQT) and Torsades de pointe (TdP). A full description of clinical features of aLQTS associated with ADT and of underlying mechanisms are lacking. Method and results We searched the WHO pharmacovigilance database for men (n=6,560,565) presenting with aLQT, TdP or sudden death (SD) associated with ADT. We identified 184 cases of aLQTS and/or TdP (11% fatal), and 99 with SD. Of the 10 ADT examined, 7 had a disproportional association (reporting-OR=1.4–4.7, p&lt;0.05) with aLQT, TdP or SD. The minimum time to SD was 0.25 days. Enzalutamide (Enza, androgen antagonist) was associated with more deaths (17%, p&lt;0.001) than other ADT used for prostate cancer (8.1%,Table). In cardiomyocytes derived from induced pluripotent stem cells (IPS-CMs) from men, we studied electrophysiological effects of enza and dihydrotestosterone (DHT). Acute and chronic enza (25μM) prolonged action potential durations (APD90-paced0.5Hz; 414±63 (control) vs. 951±67 (acute, p&lt;0.01) and 1028±63msec (chronic, p&lt;0.01), and generated early/delayed afterdepolarizations and/or triggered activity in drug treated cells (4/7 acute and 3/5 chronic). Enza acutely and chronically inhibited IKr, and chronically enhanced INa-L. DHT (30nM) reversed enza effects on IPS-CMs. In 7 men with aLQT and hypogonadism, ECGs showed low amplitude, bifid T-waves typical of IKr block which resolved with testosterone. Table 1 ndeath/ntotal (%) aLQT TdP SD n/naLQTS±TdP±SD (%) with ADT considered suspect by reporter Leuprorelin 1,871/22,113 (8.5%) 33 16 18 28/55 (50.9%) Goserelin 471/5,821 (8.1%) 8 2 15 17/22 (77.3%) Triptorelin 52/1,517 (3.4%) 6 3 2 5/8 (62.5%) Degarelix 82/2,787 (2.9%) 7 4 3 10/11 (90.9%) Bicalutamide 724/10,144 (7.1%) 23 16 11 28/41 (68.3%) Flutamide 163/4075 (4%) 4 2 3 3/7 (42.9%) Enzalutamide 5,430/31,896 (17%) 19 4 13 30/32 (93.8%) Abiraterone 1,240/14,261 (8.7%) 19 7 10 29/31 (92.5%) Finasteride 1,062/33,877 (3.1%) 52 20 32 20/87 (23%) Dutasteride 248/15,177 (1.6%) 26 7 11 5/38 (13.2%) Total ADT* 10,540/127,385 (8.3%) 168 68 99 137/283 (48.4%) Number (n) of case reports in men in the WHO international pharmacovigilance database (VigiBase) by ADT through 08/09/2018. *Some patients were on combination ADT. Enzalutamide electrophysiology IPS-CMs Conclusion ADT is a risk factor for aLQT and TdP. Androgens may be useful in TdP treatment of hypogonadic men. Acknowledgement/Funding INSERM
Wetalla to Millmerran Pipeline: Reusing Effluent to Supply the Millmerran Power Station (2002)

Industrial process water for the Millmerran Power Station is provided by pumping secondary treated sewage effluent 100 km from the Wetalla Sewage Treatment Plant near Toowoomba. (A separate source is used for potable water.) The effluent is not of sufficient quality for discharge to a watercourse, but it is suitable, with further treatment, for the power station. In designing and constructing the pipeline, special emphasis was placed on preventing accidental spills or planned releases to the environment. The pipeline and associated works can transfer 1000 ML/annum for reuse in the power station and associated coal mine.
ChemInform Abstract: SELECTIVE CARBON‐CARBON BOND FORMATION VIA TRANSITION METAL CATALYSIS. 35. A CONVENIENT SYNTHESIS OF UNSYMMETRICAL BIBENZYLS, HOMOALLYLARENES, AND HOMOPROPARGYLARENES VIA PALLADIUM‐CATALYZED CROSS COUPLING (1984)

Abstract In Gegenwart von Pd‐ oder Ni‐Katalysatoren werden Organozink(II)‐chloride mit Iodiden Bromiden in hohen Ausbeuten in der angegebenen Weise kondensiert.
Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes (2023)

Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to use the best available evidence on the potential beneficial effects of vitamin D to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in the Kingdom of Saudi Arabia and the United Arab Emirates if minimum serum 25(OH)D concentrations were to be raised to 30 ng/mL. Estimated reductions by 25% for myocardial infarction incidence, 35% for stroke incidence, 20 to 35% for cardiovascular disease mortality, and 35% for cancer mortality rates depicted a promising potential for raising serum 25(OH)D. Methods to increase serum 25(OH)D concentrations at the population level could include food fortification with vitamin D<sub>3</sub>, vitamin D supplementation, improved dietary vitamin D intake, and sensible sun exposure.
Ozone generation by a discharge in bubbled water (2003)

The final goal of this research is to realize the efficient utilization of radicals such as atomic oxygen, OH radical, and ozone for water purification. The radicals were generated by a discharge occurring inside the bubbles produced by a bubbling tube immersed in water. The Blumlein line, a repetitive pulsed power generator, was used as the power source. In the experiments, a maximum ozone concentration of approximately 300 ppm was obtained when the repetition rate of pulsed power generator, the peak value of applied voltage and the gap length, were 15 pps, approximately 30 kV, and 7.5 mm, respectively. Oxygen was used as the bubbling gas. The time duration of voltage pulse was approximately 200 ns.
Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms (2018)

With the use of both a murine VEGF inhibitor in syngeneic models, and bevacizumab in human cell line-derived xenografts, we demonstrate that ONC201 in combination with anti-angiogenic therapies such as bevacizumab represents a promising approach for further testing in the clinic for the treatment of CRC.
A denoising method forwhole-body low-dose x-ray imageswith adaptable parameter control (2013)

A denoising method is proposed for full body X-ray images, acquired under low dose conditions. The suggested algorithm is based on a non local means filter adapted to the statistics of Poisson noise. A new feature of the method is to locally set the filtering parameters in order to denoise while preserving details in low absorption regions. Thus, we propose to adapt the denoising parameters for each pixel by exploiting a global noise level measure and the standard deviation image of the gradient magnitude. Quantitative and visual results on phantom and clinical images show the interest of the method, achieving the objectives.
Influence of the pore size on the sensitivity of flexible and wearable pressure sensors based on porous Ecoflex dielectric layers (2019)

The porous elastomer was used as the dielectric layer of flexible capacitive-type pressure sensors extensively to obtain high sensitivity, of which the pore size could play an important role in improving the sensitivity of sensors. Herein, the porous Ecoflex structures with various uniform pore sizes were fabricated to develop the flexible pressure sensors. The sensitivities of the as-prepared sensors depended on the interpore wall thickness of the porous Ecoflex in the low-pressure range (0–60 Pa). The sensor with the pore size about 150–200 μm exhibits a relatively high sensitivity (~1.096 kPa−1) in the low-pressure range. Meanwhile, the as-prepared sensors can be applied as wearable devices in detecting the pulses of the carotid artery, the heartbeats, and the hand movements.
The Effect of Electrical Boundary Conditions on the Thermal Properties of Ferroelectric Piezoelectric Ceramics (2016)

The thermal conductivity of polycrystalline bulk PZT (lead-zirconate-titanate) has been investigated according to electrical boundary conditions and poling. The thermal conductivity of poled PZT was measured in the poling direction for open circuit and short circuit conditions. The short circuit thermal conductivity had the largest thermal conductivity. The relationship between these two thermal properties, the electrothermal coupling factor $k_{33}^κ$, was found to be similar to the electromechanical coupling factor $k_{33}$ relating elastic compliance under short circuit and open circuit conditions. The thermal conductivity of the unpoled sample was found to have the lowest thermal conductivity. The significance of the thermal conductivity with regards to phonon mode scattering and elastic compliance was discussed.
Estimation in the Mean Residual Life Regression Model (1994)

SUMMARY The proportional mean residual life model was originally proposed by Oakes and Dasu. This model can be extended to a regression model with explanatory variables. We consider the problem of estimation of the regression parameter in this general model. We investigate two types of estimator, of which one is based on the maximum likelihood equation of the exponential regression model, and the other is based on the underlying proportional hazards structure of the model and Cox's estimating equation. We show that these estimators are consistent and asymptotically normal. We compare their performance by simulations.
Emotional Arousal Can Impair Feature Binding in Working Memory (2006)

To investigate whether emotional arousal affects memorial feature binding, we had participants complete a short-term source-monitoring task-remembering the locations of four different pictures over a brief delay. On each trial, the four pictures were all either high arousal, medium arousal, or low arousal. Memory for picture-location conjunctions decreased as arousal increased. In addition, source memory for the location of negative pictures was worse among participants with higher depression scores. Two subsequent functional magnetic resonance imaging experiments showed that relative to low-arousal trials, high- and medium-arousal trials resulted in greater activity in areas associated with visual processing (fusiform gyrus, middle temporal gyrus/middle occipital gyrus, lingual gyrus) and less activity in superior precentral gyrus and the precentral-superior temporal intersect. These findings suggest that arousal (and perhaps negative valence for depressed people) recruits attention to items thereby disrupting working memory processes that help bind features together.
Quasi-Two-Dimensional Intermetallic Electride CeRuSi for Efficient Alkaline Hydrogen Evolution (2023)

Electrides are emerging catalyst materials, in which excess electrons serve as periodic anions. Although they have been successfully used for various hydrogenation reactions, due to weak chemical stabilities, their applications in aqueous systems remain challenging. Herein, we develop a quasi-two-dimensional (2D) intermetallic electride CeRuSi as a high-performance alkaline hydrogen evolution electrocatalyst, realizing an ultralow overpotential of 28 mV at a current density of 10 mA/cm2 and long-term stability in 1.0 M KOH. The rate-determining step is deduced to be the Tafel step with accelerated kinetics. We show that CeRuSi is so far the best electride-based electrocatalyst for hydrogen evolution. We further demonstrate that high activity is mainly ascribed to the unique electride features and the coordinatively unsaturated Ru sites, exposed and activated via selective chemical etching. Finally, we confirm the superior catalytic performance using density functional theory calculations and find an optimized H adsorption energy over the Ru active centers. This work will stimulate more electrocatalytic studies on electrides and provide guidance for the design of electrocatalysts.
Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle. (1999)

Several reports indicate that protein kinase C (PKC) plays a role in insulin-induced glucose transport in certain cells. The precise effects of insulin on specific PKC isoforms are as yet unknown. Utilizing primary cultures of rat skeletal muscle, we investigated the possibility that insulin may influence the activation state of PKC isoenzymes by inducing their translocation and tyrosine phosphorylation. This, in turn, may mediate insulin effects on glucose transport. We identified and determined the glucose transporters and PKC isoforms affected by insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA). Insulin and TPA each caused an increase in glucose uptake. Insulin translocated GLUT3 and GLUT4 without affecting GLUT1. In contrast, TPA translocated GLUT1 and GLUT3 without affecting GLUT4. Insulin translocated and tyrosine phosphorylated and activated PKC-beta2 and -zeta; these effects were blocked by phosphatidylinositol 3-kinase (PI3K) inhibitors. TPA translocated and activated PKC-alpha, -beta2, and -delta; these effects were not noticeably affected by PI3K inhibitors. Furthermore, wortmannin significantly inhibited both insulin and TPA effects on GLUT translocation and glucose uptake. Finally, insulin-induced glucose transport was blocked by the specific PKC-beta2 inhibitor LY379196. These results indicate that specific PKC isoenzymes, when tyrosine-phosphorylated, are implicated in insulin-induced glucose transport in primary cultures of skeletal muscle.
All-Digital Closed-Loop Unified Retention/Wake-Up Clamp in a 10nm 4-Core x86 IP (2021)

A 10nm 4-core x86 IP with multiple low-power states including C1 (clock-gated core), C6 (power-gated core) and a new state called C1LP where the core voltage is lowered to its retention voltage (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RETENTION</inf> ) is presented. All-digital closed-loop unified retention clamp for C1LP and wake up for C6 shows power savings of 33%/28% for core/IP, with 120ns wake up latency while addressing impact of PVT variations.
Enterovirus 75 Encephalitis in Children, Southern India (2010)

Recent outbreaks of enterovirus in Southeast Asia emphasize difficulties in diagnosis of this infection. To address this issue, we report 5 (4.7%) children infected with enterovirus 75 among 106 children with acute encephalitis syndrome during 2005-2007 in southern India. Throat swab specimens may be useful for diagnosis of enterovirus 75 infection.
Re-Programming Photosynthetic Cells of Perennial Ryegrass (Lolium perenne L) for Fructan Biosynthesis through Transgenic Expression of Fructan Biosynthetic Genes under the Control of Photosynthetic Promoters (2017)

High molecular weight fructans are the main class of water-soluble carbohydrate used for energy storage in many temperate grass species including perennial ryegrass (Lolium perenne L.). As well as being important readily mobilisable energy reserves for the plant, fructans are also involved in stress tolerance. Fructans are also readily digested by grazing ruminants and hence are a valuable source of energy for sheep, beef and dairy production systems in temperate regions. This paper describes the re-programming of the expression of fructan biosynthesis genes through the transgenic manipulation of 6-glucose fructosyltransferase (6G-FFT) and sucrose:sucrose 1-fructosyl-transferase (1-SST) in perennial ryegrass. Transgenic events were developed with altered fructan accumulation patterns with increases in fructan accumulation and greatly increased accumulation of fructan in leaf blades as opposed to the traditional site of fructan accumulation in the pseudostem. This altered site of fructan accumulation has potential benefits for animal production as leaf blades form the major part of the diet of grazing ruminants. Some of the transgenic events also exhibited enhanced biomass production. This combination of high quality and enhanced yield is of great interest to forage plant breeders and whilst the expression of these phenotypes needs to be confirmed under field conditions, the identification and characterisation of the transgenic events described in this paper validate the potential for the manipulation of fructan biosynthesis in perennial ryegrass.
Jump-Diffusion Modeling of a Markov Jump Linear System with Applications in Microgrids (2021)

This paper is about the derivation of a jump-diffusion model of a microgrid operating between standalone and grid-tied modes.
The Liability of Advising Bank in Respect of Its Negligence (2011)

UCP600은 통지은행의 의무로 외견상 진위성의 확인과 통지의 정확성을 규정하고 있지만 통지은행의 수익자에 대한 신속한 통지에 대하여는 아무런 규정도 하지 않고 있다. 통지은행의 고의 또는 중대한 과실로 인한 통지 지연에 따른 손해에 대하여는 통지은행의 불법행위에 기초한 손해 배상청구가 가능하지만 태만으로 인한 통지 지연에 따른 손해에 대해서는 판례에서...
Polarography of Tin(IV)-Pyrogallol Complexes. (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarography of Tin(IV)-Pyrogallol Complexes.A. J. BardCite this: Anal. Chem. 1962, 34, 2, 266–269Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/ac60182a035https://doi.org/10.1021/ac60182a035research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A low-Ca2+ response operon encodes the V antigen of Yersinia pestis (1986)

Yersinia pestis has a virulence regulon called the low-Ca2+ response that is mediated by the plasmid pCD and manifested as regulation of growth and of expression of several virulence-associated properties by Ca2+ and temperature. We used Mu dI(Ap lac) to obtain a mutation in pCD1 of Y. pestis KIM that rendered the bacteria unable to express one of these properties, the V antigen. This mutant also had lost the Ca2+ requirement for growth at 37 degrees C and was avirulent in mice. Two-dimensional protein gel electrophoresis showed that the Mu dI(Ap lac) insertion had eliminated 13,000- and 18,000-molecular-weight proteins in addition to the V antigen. We mapped the Mu dI(Ap lac) insertion within pCD1, cloned the HindIII fragment spanning the insertion location, prepared two subclones of this fragment, and identified the proteins these clones expressed in Escherichia coli minicells. The data indicated that the V gene lies within an operon containing three genes; lcrG (encoding the 13,000-molecular-weight protein), lcrV (encoding the 38,000-molecular-weight V antigen), and lcrH (encoding the 18,000-molecular-weight protein). Therefore, the V operon contains the structural gene for V antigen, at least one virulence gene, and at least one Ca2+-dependence gene.
Representations of Vision: Trends and Tacit Assumptions in Vision Research (1991)

Preface Acknowledgements Part I. Visual Pyramids and Neural Networks E. Bienenstock and A. Gorea: 1. Pyramids and multiscale representations E. H. Adelson, E. P. Simoncelli and W. T. Freeman 2. Multidimensional pyramids in vision and video A. B. Watson 3. Self-similar oriented wavelet pyramids: conjectures about neural non-orthogonality J. G. Daugman 4. Issues of representation in neural networks E. Bienenstock and R. Doursat Part II. Visual Cortical Processing: From Perception to Memory Y. Fregnac and A. Gorea: 5. Recent progress toward an understanding of experience-dependent visual cortical plasticity at the molecular level M. F. Bear 6. Synchronous neuronal oscillations in cat visual cortex: functional implications C. M. Gray, A. K. Engel, P. Konig and W. Singer 7. How many cycles make an oscillation? Y. Fregnac 8. Elements of form perception in monkey prestriate cortex E. Peterhans and R. von der Heydt 9. Manipulating perceptual decisions by microstimulation of extrastriate visual cortex W. T. Newsome, C. D. Salzman, C. M. Murasugi and K. H. Britten 10. Primal long-term memory in the primate temporal cortex: linkage between visual perception and memory Y. Miyashita, N. Masui and S. Higuchi Part III. Eye Movement and Vision J. Findlay and Z. Kapoula: 11. The effect of cortical lesions on visuo-motor processing in man C. Kennard 12. Binocular eye-movements and depth perception H. Coolewijn, J. van der Steen and L. J. van Rijn 13. The parsing of optic flow by the primate oculomotor system F. A. Miles, U. Schwarz and C. Busettini 14. Current views on the visuo-motor interface of the saccadic system J. A. M. Van Gisbergen, A. J. Van Opstal and A. W. A. Minken Part IV. Tacit Assumptions in Vision Research A. Gorea and M. Imbert: 15. Thoughts on the specific nerve energy A. Gorea 16. The duality of psycho-physics S. Klein 17. Some tacit assumptions in visual psychophysics C. W. Tyler 18. Hidden assumptions in seeing shape from shading and apparent motion S. Anstis 19. What's up in top-down processing? P. Cavanagh 20. Tacit assumptions in the computational study of vision S. Ullman 21. Vision tells you more than 'what is where' H. B. Barlow 22. Some strategic questions in visual perception B. Julesz.