gebhart/patrepeval huggingface dataset:
Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane (2020)

Abstract Seipin is a disk-like oligomeric ER protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can trap TAGs in the ER bilayer via the luminal hydrophobic helices of the protomers delineating the inner opening of the seipin disk. This promotes the nanoscale sequestration of TAGs at a concentration that by itself is insufficient to induce TAG clustering in a lipid membrane. We identify Ser166 in the α3 helix as a favored TAG occupancy site and show that mutating it compromises the ability of seipin complexes to sequester TAG in silico and to promote TAG transfer to LDs in cells. While seipin-S166D mutant colocalizes poorly with promethin, the association of nascent wild-type seipin complexes with promethin is promoted by TAGs. Together, these results suggest that seipin traps TAGs via its luminal hydrophobic helices, serving as a catalyst for seeding the TAG cluster from dissolved monomers inside the seipin ring, thereby generating a favorable promethin binding interface.
Physiological Responses to Narrative Anger Recall and Correlates to Anger, Forgiveness, and Rumination (2022)

Abstract. Narrative recall, or describing an event from one’s past, is a common method to study anger in the laboratory. However, most research using this method has not included a neutral speaking control, and therefore the physiological response attributable to emotion versus the act of speech is unknown. We evaluated heart rate, blood pressure, skin conductance level, heart rate variability, and salivary alpha-amylase during silent baseline, neutral speaking, anger recall, and recovery periods, and correlated these measures with trait anger, forgiveness, and rumination ( n = 104). Only systolic blood pressure and skin conductance levels were elevated in the anger recall period above the values in the neutral speaking period, showing the need for this important control. Alpha-amylase was inversely correlated to forgiveness, particularly in females. A neutral speaking control is critical for anger recall protocols because the physiological responses are mostly due to speaking, not anger. Salivary alpha-amylase may be a promising autonomic marker in studies of forgiveness and anger.
One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial (2022)

Efficacy improved beyond the 12-week trials, with a 40.9% complete disease clearance rate, ∼4-month off therapy remittive effect, durability on therapy, and consistent safety.
Selectable flight tube design developments for iter fueling, ELM pacing, and impurity pellets (2015)

ITER fueling and Edge Localized Mode (ELM) pacing pellets will be created by punching and chambering pellets with a solenoid operated cutter from an extrudate formed by a twin-screw extruder. The cut pellets are then accelerated down a flight tube by a fast pneumatic valve. The impurity pellets are formed in-situ with a pipe gun technique and accelerated down a flight tube with the same pneumatic valve design.
The influence of rat suspension-hypokinesia on the gastrocnemius muscle. (1984)

Hind-limb hypokinesia was induced in rats by the Morey method to characterize the response of the gastrocnemius muscle. A comparison of rats suspended for 2 weeks with weight, sex, and litter-matched control rats indicate no difference in gastrocnemius wet weight, contraction, or one-half relaxation times, but less contractile function as indicated by lowered dP/dt. Myosin ATPase staining identified uniform Type I (slow-twitch) and II (fast-twitch) atrophy in the muscles from 4 of 10 rats suspended for 2 weeks and 1 of 12 rats suspended for 4 weeks; muscles from three other rats of the 4-week group displayed greater Type I atrophy. Other histochemical changes were characteristic of a neuropathy. These data together with recently acquired soleus data (29) indicate the Morey model, like space flight, evokes greater changes in the Type I or slow twitch fibers of the gastrocnemius and soleus muscles.
Epitaxial Bi-layered perovskite ferroelectric thin film heterostructures by large area pulsed laser deposition (1999)

Abstract Epitaxial thin films of Bi4Ti3O12, SrBi2Ta2O9 and BaBi4Ti4O15 have been epitaxially deposited onto 3-inch substrates by large area pulsed laser deposition. The out-of-plane orientation of the layers is characterized by a FWHM of the rocking curve Δωin the range of 0.9° to 2.1° and their in-plane orientation by a FWHM of the phi-scan ω π ranging from 3° to 4.5°. The composition is uniform across the whole 3-inch wafer and a thickness uniformity in the range of 5 to 10% of the mean thickness has been achieved. The ferroelectric properties of the Bi-layered perovskite layers depend strongly on their microstructure and crystallographic orientation. The remnant polarization of SrBi2Ta2O9 films is ranging from Pr = 0.2 μC/cm2 for films having only c-oriented crystallites to Pr = 1 μC/cm2 for films containing a substantial fraction of crystallites with their c-axis in the plane of the film.
Reply (2012)

Lyamina, Nadezhda P.; Lyamina, Svetlana V.; Senchikhin, Valery N.; Mallet, Robert T.; Downey, H. Fred; Manukhina, Eugenia B. Author Information
Reducing the Impact of Intrachannel Nonlinearities By Pulse-Width Optimisation in Multi-level Phase-Shift-Keyed Transmission (2009)

We investigate the reduction in the duty-cycle for M-phase-shift-keyed transmission, demonstrating performance improvement in the range of 2-8 dB in nonlinear threshold (NLT) due to intrachannel-four wave mixing (IFWM) and nonlinear phase noise (NLPN). © VDE VERLAG GMBH.
MMSE scaling enhances performance in practical lattice codes (2014)

We investigate the value of MMSE scaling for practical lattice codes. For ideal lattices, MMSE scaling has been shown to be a key ingredient in achieving the capacity of the AWGN channel. We demonstrate that MMSE scaling enhances the performance, particularly at low SNR, for practical lattice codes. For example, a dimension n = 10000 LDLC lattice exhibits approximately 0.6 dB gain when MMSE scaling is used for a rate of 1 bit/dimension. Furthermore, we provide a novel derivation of the MMSE scaling rule, showing that it emerges naturally from principles of belief propagation decoders which account for the transmit power constraint.
Pressure losses and flow field distortion induced by tip clearance of centrifugal and axial compressors. (1987)

The flow field near the tip of compressor rotor blades is distorted by leakage through the tip clearance and the performance of the compressor is deteriorated. The literature regarding the tip clearance of compressor blades consists of computational fluid mechanics and experimental studies on the flow field and the pressure loss. Empirical equations expressing the pressure loss and the efficiency drop are varied. They relate to the lift coefficient in different ways, such as proportional to CL, CL1.5, CL2, or the sum of two terms, depending upon the ways of understanding the mechanics of pressure losses. These methods are examined and compared. Also, a brief discussion is made on the optimum value of the tip clearance.
Transmission Benefit Quantification, Cost Allocation and Cost Recovery (2008)

This project was commissioned to perform a scoping study to understand transmission benefit quantification, cost allocation, cost recovery, and project approval processes with a particular focus on recommending new methods for improved benefit quantification and cost allocation that better fits the new electric industry structure and planning environment.Research goals and objectives included:1. Review methodologies currently being used for transmission project quantification.2. Review and summarize benefit analysis that have been carried out for some recent transmission projects in California.3. Present and summarize research results to improve benefit quantification methods for new transmission projects.4. Outline approaches to apply improved benefit quantification method to: evaluate project cost effectiveness, allocate project costs among participants, and develop framework for cost recovery.Key conclusions and research recommendations are: Use a social rate of discount to calculate the present worth of benefits of a new major regional transmission projects rather than utility cost of capital to recognize the public good and long life attributes of transmission. Calculate explicitly the fuel diversity benefit from integration of large renewable resources. Utilize a stakeholder consensus approach, such as Delphi method, to assign value to some of the strategic benefits such as risk mitigation against extreme reliability and market volatility events. Initiate research into (a) dynamic analysis to evaluate the impact on generation expansion in exporting regions (b) resource portfolios analysis to assess performance of different combination of demand response, renewables and fuel based generation, transmission and energy conservation programs, and (c) quantification of extreme event benefits (Insurance Value) in terms of reliability and reduced market volatility to estimate the benefits from the low probability/high impact events.
A Method for Studying the Structure of Low-Temperature Ionic Liquids by XAFS (1999)

An in situ method of studying the structure of reactive ionic materials in the solid and liquid states by XAFS is described. These salts have novel catalytic and solvent properties, and the results show that their structure may be studied using transmission XAFS by utilizing pressed disks of BN, graphite, and LiF and is not affected by the sample matrix used.
FOXO3A acts as immune response modulator in human virus-negative inflammatory cardiomyopathy (2023)

FOXO3A might act as modulator of the cardiac immune response, diminishing cardiac inflammation and injury in pathogen-negative DCMi.
Advanced Ceramics Property Measurements (2013)

Mechanical and physical properties of ceramic bodies can be difficult to measure correctly unless the proper techniques are used. The Advanced Ceramics Committee of ASTM, C-28, has developed dozens of consensus test standards and practices to measure various properties of a ceramic monolith, composite, or coating. The standards give the what, how, how not, and why for measurement of many mechanical, physical, thermal, and performance properties. Using these standards will provide accurate, reliable, and complete data for rigorous comparisons with other test results from your test lab, or another. The C-28 Committee has involved academics, producers, and users of ceramics to write and continually update more than 45 standards since the committee's inception in 1986. Included in this poster is a pictogram of the C-28 standards and information on how to obtain individual copies with full details or the complete collection of standards in one volume.
Effects of Glyphosate/Growth Regulator Combinations on Blackberry Control, The (1982)

Blackberry plants (Rubus allegheniensis Porter) from a wild o l on e were treated with growth regul at o rs at known rates f or g rowth inhibition in c ombina ti on with a glyph osate application at 1. 26 kg ae/ha.Results of these experiments indicated that applic ati on of ABA at 300 ppm w/ v applied 24 h ours after a glyphoaate treatment, ABA at 300 ppm w/ v applied in the Bpr~ s olution, or ethephon applied at 500 or 1, 000 ppm w/v applied in the spray solution had no beneficial effect on g lyphosate activity.Th e use of MH at 1 t 000 ppm applied in the 8p~ s oluti on reduced the effectiveness of glyphosate.The use of SADH at 2, 000 ppm w/ v in the spray s olution or applied 9 dB3B before a glyphosate treatment g enerally reduced.the number of' adventitious buds per crown and increased herbicidal activity.The use of SADH at 5, 000 ppm w/ v applied in the spra;y solution or applied 9 dBJ's before a glyphosate treatment in most cases was not as effective as the 2 , 000 ppm w/ v * Grad.Res.Assft.and Assoc.Prof. of Ha rt., respectively, Plant Sci.Dep., Univ. of Conn., storrs, CT
Real-time single-workstation obstacle avoidance using only wide-field flow divergence (1996)

A real-time robot vision system is described which uses only the divergence of the optical flow field for both steering control and collision detection. The robot has wandered about the lab at 20 cm/s for as long as 26 minutes without collision. The entire system is implemented on a single ordinary UNIX workstation without the benefit of real-time operating system support. Dense optical flow data are calculated in real-time across the entire wide-angle image. The divergence of this optical flow field is calculated everywhere and used to control steering and collision behavior. Divergence alone has proven sufficient for steering past objects and detecting imminent collision. The major contribution is the demonstration of a simple, robust, minimal system that uses flow-derived measures to control steering and speed to avoid collision in real time for extended periods. Such a system can be embedded in a general, multi-level perception/control system.
Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood (2012)

Binding of Glu-plasminogen (the native, circulating form of the zymogen) to cells results in enhancement of its activation. Cell-associated plasmin proteolytic activity is a key component of physiologic and pathologic processes requiring extracellular matrix degradation. Recently, we developed antiplasminogen mAbs that recognize receptor-induced binding sites (RIBS) in Glu-plasminogen and, therefore, preferentially react with cell-associated Glu-plasminogen in the presence of soluble Glu-plasminogen. Here we have used FACS with a representative antiplasminogen receptor-induced binding site mAb, mAb49, to examine whether plasminogen associates with peripheral blood cells in blood. Plasminogen binding to neutrophils, monocytes, B-lymphocytes, T-lymphocytes, and platelets was clearly detected. Treatment of whole blood with lipopolysaccharide or 12-0 tetradecanoylphorbol-13-acetate up-regulated plasminogen binding to neutrophils and in vivo treatment with all-trans retinoic acid decreased plasminogen binding to acute promyelocytic leukemia blasts. Our results demonstrate that mAb49 can be used to monitor cell-bound plasminogen in blood under both normal and pathologic conditions.
Investigation into Sizing Photovoltaic with Energy Storage for Off-Grid Transactive Scenarios (2021)

In this study, a novel sizing methodology was developed for centralized and interconnected operating strategies of transactive microgrids and several variables were investigated including starting month, initial charge of battery, load variability, unit cost of solar panels and energy storage, number of systems, climate, and required reliability to determine their effect on total cost. The centralized strategy improved cost by seven to ten percent compared to the isolated strategy in every case. The interconnected strategy saved an incremental amount of money consistently compared to the isolated standard. The number of connected systems was not a strong effect. It was thought that increasing the number of systems would increase the benefit of energy sharing. Climate zones studied (“Cold”; “Hot-Dry/Mixed Dry”; “Mixed Humid”; and “Cold but with lower solar irradiation”) showed a large variation on cost with the Hot-Dry/Mixed Dry being the least expensive and Cold, with lower solar irradiation being the most expensive. Cost sensitivity analysis was performed showing that the unit cost of solar has a greater effect on the total cost. Required reliability of power, measured in outage hours, exhibited an inverse relation with cost.
Investigations on the Separation of Platinum Nanoparticles With Magnetic Beads (2014)

The magnetic capture and manipulation of metallic nanoparticles can be interesting for many small-scale synthetic reactions, e.g., in the area of fine chemical production. Here, the separation of colloidal platinum nanoparticles from solution by means of magnetic beads is investigated. Therefore, magnetic beads functionalized with avidin are employed and a functionalization of the metal nanoparticles with biotin is performed. It is shown that the functionalized nanoparticles can be separated by the magnetic beads with common external magnetic field strengths. Furthermore, since a regain of the catalytic nanoparticles material is of inherent interest, several means of separation of the nanoparticles from the magnetic beads are investigated and compared.
Space Vehicle Communication and Networking (2010)

Abstract Space missions range from Earth‐orbiting satellites to deep space and planetary surface missions. Issues such as time delay, blackout periods, bandwidth limitations, and power constraints make space‐based communication a unique challenge. This chapter overviews the challenges associated with spacecraft communication and solutions adopted and advanced for spaceflight. These challenges have motivated the development and deployment of strategically placed relay stations on the Earth and in space. Spacecraft communications structure and protocols will be overviewed, and associated engineering considerations with ground systems. Data compression and onboard processing will be introduced as methods with potential to better utilize available bandwidth.
Estrogen receptor based in vitro assays for the evaluation of endocrine disrupters (2002)

An increasing number of environmental chemicals is suspected to act similarly as endogenous estrogens at concentrations far below the so called No Observed Adverse Effect Levels. In man, as in wildlife, these substances are held responsible for several reproductive disorders e.g. the decline in sperm quality and the increase in testicular cancer incidence in different countries worldwide. Several in vitro bioassays have recently been developed to screen single compounds for their ability to bind to estrogen receptors (ER) resulting in a hormone specific response. However, divergent results from these assays indicate the lack of validation and standardisation. Moreover, the proven cell specificity of estrogen response questions the relevance of the observed effects and necessitates the development of assays in a fertility related cellular context.
Cardiovascular health and cognitive outcomes: Findings from a biracial population‐based study in the United States (2023)

Promoting CVH in communities with Black residents may lower the future risk of Alzheimer's dementia.
Impacts of Periodical Burst Packet Loss on Streaming Applications -- Focusing on a Mobile Network in a High-Speed Train (2014)

This paper investigates impacts of periodical burst packet loss on three typical streaming applications: YouTube, Internet Radio, and Skype, supposing a mobile network in a high-speed train. Although the characteristics of YouTube and Skype are well analyzed, the characteristics of Internet Radio and the characteristics of these applications under periodical burst packet loss have not been analyzed. First, this paper analyses how much these applications are tolerant to periodical burst packet loss. Second, this paper analyses correlation between application layer protocols and transport layer protocols. As a result, some correlations between transport layer protocols and application layer protocols were found. For example, in YouTube, if TCP segment retransmissions frequently occur before starting content download, a client tries to download the entire content with a single HTTP request while a client repeatedly downloads a chunk of the content with multiple HTTP requests under ordinary network condition.
Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration (2014)

Epithelial adhesion molecules play essential roles in regulating cellular function and maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to provide structural support for epithelial monolayers and act as a selectively permeable barrier separating luminal contents from the surrounding tissue. Others serve as docking structures for invading viruses and bacteria, while also regulating the immune response. They can either obstruct or serve as footholds for the immune cells recruited to mucosal surfaces. Currently, it is well appreciated that adhesion molecules collectively serve as environmental cue sensors and trigger signaling events to regulate epithelial function through their association with the cell cytoskeleton and various intracellular adapter proteins. Immune cells, particularly neutrophils (PMN) during transepithelial migration (TEM), can modulate adhesion molecule expression, conformation, and distribution, significantly impacting epithelial function and tissue homeostasis. This review discusses the roles of key intestinal epithelial adhesion molecules in regulating PMN trafficking and outlines the potential consequences on epithelial function.
Modeling Sensor Networks Through Design and Simulation (2010)

This chapter contains sections titled: Introduction Why a New Simulator Currently Available Simulators Simulation Design Implementation Details Experimental Results Final Comments Appendix Acknowledgments Problems References
DroidAutoML: uma Ferramenta de AutoML para o Domínio de Detecção de Malwares Android (2022)

Neste trabalho apresentamos a DroidAutoML, uma ferramenta de AutoML especializada para o domínio de detecção de malwares Android. A partir de um dataset de entrada e um pipeline de dados de quatro estágios, a DroidAutoML possibilita a geração automática de modelos preditivos otimizados. Os resultados iniciais indicam que a ferramenta é capaz de gerar modelos muito bons, chegando a 95% de recall.
Quantum behavior of a flux qubit coupled to a resonator (2010)

The detailed theory for the system of a superconducting qubit coupled to the transmission line resonator is presented. We describe the system by solving analytically and numerically the master equation for the density matrix, which includes dissipative Lindblad term. We calculate the transmission coefficient, which provides the way to probe the dressed states of the qubit. The theoretical results are related to the experiment with the intermediate coupling between the qubit and the resonator, when the coupling energy is of the same order as the qubit relaxation rate.
Elastography of multicellular aggregates submitted to osmo-mechanical stress (2015)

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