gebhart/patrepeval huggingface dataset:
Quantitative Liquid Chromatography–Nanoelectrospray Ionization–High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers (2020)

Cigarette smoking is an important source of human exposure to toxicants and carcinogens and contributes significantly to cancer morbidity and mortality worldwide. Acrolein, a widespread environmental pollutant, is present in relatively high amounts in cigarette smoke and can react directly with DNA to form DNA adducts, which serve as important biomarkers for the assessment of exposure to acrolein and its potential role in smoking related cancer. Etheno-DNA adducts are promutagenic DNA lesions that can derive from exogenous chemicals as well as endogenous sources, including lipid peroxidation. In this study, we developed a combined method for the quantitation of (6<i>R</i>/<i>S</i>)-3-(2'-deoxyribos-1'-yl)-5,6,7,8,-tetrahydro-6-hydroxypyrimido[1,2-<i>a</i>]purine-10(3<i>H</i>)-one (α-OH-Acr-dGuo), (8<i>R</i>/<i>S</i>)-3-(2'-deoxyribos-1'-yl)-5,6,7,8,-tetrahydro-8-hydroxypyrimido[1,2-<i>a</i>]purine-10(3<i>H</i>)-one (γ-OH-Acr-dGuo), 1,<i>N</i><sup>6</sup>-etheno-dAdo (εdAdo), and 3,<i>N</i><sup>4</sup>-etheno-dCyd (εdCyd) adducts in oral rinse and cytobrush DNA from smokers and nonsmokers by liquid chromatography-nanoelelctrospray ionization-high-resolution tandem mass spectrometry (LC-NSI-HRMS/MS). For oral rinse samples, there was a statistically significant difference between the levels of α-OH-Acr-dGuo, γ-OH-Acr-dGuo, εdAdo, and εdCyd in smokers (12.1 ± 17.9, 163 ± 227, 182 ± 568, and 194 ± 400 adducts/10<sup>9</sup> nucleotides, respectively) and nonsmokers (1.85 ± 2.08, 5.95 ± 4.23, 7.69 ± 11.7, and 6.07 ± 10.9 adducts/10<sup>9</sup> nucleotides, respectively). For cytobrush samples, there was a statistically significant difference between the levels of γ-OH-Acr-dGuo and εdAdo in smokers (259 ± 540 and 82.9 ± 271 adducts/10<sup>9</sup> nucleotides, respectively) and nonsmokers (7.37 ± 5.09 and 16.2 ± 30.2 adducts/10<sup>9</sup> nucleotides, respectively) but not for α-OH-Acr-dGuo and εdCyd. Our results demonstrate that oral mucosa cells are an excellent source of material for evaluating DNA adducts to be used as biomarkers of tobacco smoke exposure and molecular changes potentially related to cancer.
Vorlesung "Softwaretechnik I", SS 2013, gehalten am 17.07.2013 (2013)

Der Inhalt der Vorlesung ist der gesamte Lebenszyklus von Software von der Projektplanung über die Systemanalyse, die Kostenschätzung, den Entwurf und die Implementierung, die Validation und Verifikation, bis hin zur Wartung von Software. Weiter werden UML, Entwurfsmuster, Software-Werkzeuge, Programmierumgebungen und Konfigurationskontrolle behandelt.
A BIOSPI MODEL OF LYMPHOCYTE-ENDOTHELIAL INTERACTIONS IN INFLAMED BRAIN VENULES (2003)

This paper presents a stochastic model of the lymphocyte recruitment in inflammed brain microvessels. The framework used is based on stochastic process algebras for mobile systems. The automatic tool used in the simulation is the BioSpi. We compare our approach with classical hydrodinamical specifications.
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training (2022)

Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.
Discrete and continuous disorder in superlattices (1989)

We have derived a general diffraction relation for crystalline-crystalline superlattices including discrete fluctuations on the number of atoms in a layer and continuous fluctuations on the interface distance, both of a Gaussian type. We show that discrete fluctuations can markedly increase the linewidth of high-angle (large-q) diffraction peaks in lattice-mismatched systems. Moreover, we show that this line broadening increases strongly with increasing lattice mismatch and prove that these fluctuations on lattice-matched systems such as semiconductor superlattices are difficult to detect by high-angle diffraction techniques. These results have serious implications for the classical interpretation of x-ray diffraction from superlattices regarding the determination of elastic strains and the reconstruction of composition profiles.
A comprehensive evaluation of full-reference image quality assessment algorithms on KADID-10k (2019)

Significant progress has been made in the past decade for full-reference image quality assessment (FR-IQA). However, new large scale image quality databases have been released for evaluating image quality assessment algorithms. In this study, our goal is to give a comprehensive evaluation of state-of-the-art FR-IQA metrics using the recently published KADID-10k database which is largest available one at the moment. Our evaluation results and the associated discussions is very helpful to obtain a clear understanding about the status of state-of-the-art FR-IQA metrics.
Magnetic, Optical and Structural Property Studies of Mn-Doped ZnO Nanosheets (2012)

We report the synthesis of pure and Mn doped ZnO in the form of nanosheets using a simple and single step procedure involving a microwave assisted chemical method. As prepared Mn-doped ZnO nanosheets were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultra violet-visible (UV-Vis), Raman spectroscopy and magnetization measurements. The structural studies using XRD and TEM revealed the absence of Mn-related secondary phases and showed that Mn-doped ZnO comprise a single phase nature with wurtzite structure. FESEM and TEM micrographs show that the average diameter of Mn-ZnO assembled nanosheets is about approximately 50 nm, and the length of a Mn-doped ZnO nanosheet building block which is made up of thin mutilayered sheets is around approximately 300 nm. Concerning the Raman scattering spectra, the shift in peak position of E2 (high) mode toward low frequencies due to the Mn doping could be explained well by means of the spatial correlation model. Magnetic measurements showed that Mn-doped ZnO nanosheets exhibit ferromagnetic ordering at or above room temperature.
A Practical Synthesis of a Key Intermediate of Beraprost (2018)

A practical eight-step synthesis of a key intermediate of beraprost is described. The tricyclic cyclopent[ b]benzofuran core can be prepared from 2,6-dibromo-4-chlorophenol. The butyric side chain is introduced by ortho-selective metal–halogen exchange and subsequent coupling with 4-(benzyloxy)butanal. The procedure is operationally simple and amenable to scale-up synthesis.
Mutagenicity of Inhalable Particulate Matter at Four Sites in New Jersey (2018)

This chapter examines the mutagenicity of the extractable organic material associated with inhalable particles at the airbourne toxic element and organic substance urban and rural sites over a two-year period. It evaluates seasonal variations in mutagenic activity, and attempts to relate mutagenic activity to some aspects of chemical composition. These data may be used for future epidemiological studies on the effects of air pollution on human health. In assessing potential health impacts associated with airborne particulate matter, the size of the particles collected is a crucial factor. In addition, the mutagenicity data on ambient air in New Jersey will be essential in evaluating the results of future site-specific studies on local air pollution sources in the state, and in examining long-term trends in ambient air quality. The standard Ames Salmonella reverse mutation plate incorporation assay was initially conducted using bacterial strains TA98, TA100, TA1535, TA1537, and TA1538.
via water table management techniques: evolution and release of nitrous oxide (2000)

Nitrate (NO3‐N) commonly accumulates in soils because of fertilizer additions or when crop demand is much less than the rate of NO3‐N production. Water table management (WTM) has been proposed to stimulate denitrifying bacteria, thus removing the accumulated NO3‐N by converting it to N2O (a greenhouse gas) and N2. We studied the emission of N2O and N2 as aAected by water table depth. Undisturbed soil columns (30 cm dia by 90 cm long) from three soil series (Blount, somewhat poorly drained Aeric Ochraqualf; Clermont, poorly drained Typic Glossaqualf; and Huntington, well drained Fluventic Hapludoll) were treated with 2.11 g N (as KNO3) applied as a band 10 cm below the surface. Two diAerent WTM schemes were studied: static (WTM1) and dynamic (WTM2). We repeated WTM2 using 15 N and this treatment, applied to the Huntington
Supplementary Figure 5 from Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis (2023)

&lt;p&gt;Mortalin overexpression caused increase in MMP-2 and MMP-9.&lt;/p&gt;
Abstract 14736: Prevalence of Short Stature and Growth Hormone Deficiency and Factors Associated With Short Stature in Patients After Fontan Surgery (2018)

Background: Fontan circulation is characterized by many features commonly observed in heart failure, which may affect physical growth of patients with or without pituitary gland dysfunction. The pu...
ABAQUS implementation and simulation results of the MORPH constitutive model (2017)

Commercial Finite element methods software packages like MARC or ABAQUS provide the well known hyper-elastic and viscoelastic material models for rubber, the Ogden model or Prony series. Since ABAQUS is geared towards an Eulerian description of constitutive equations, the MORPH model has to be adapted to accommodate to this formulation. In addition, efficient methods to compute the material stiffness matrix are shown. Finally some results of 3D ABAQUS simulations using the MORPH material model are presented. The Morph Constitutive Model was developed to simulate large deformations in highly filled elastomers, with the main focus on the reproduction of the Mullins softening. To simulate rubber components with an adequate precision, a constitutive model is needed, which reproduces the complex material behaviour of filled rubber. This includes at least highly nonlinear stress–strain curves, hysteresis and the softening after prestrain known as the Mullins effect.
Scalable Web clusters with static and dynamic contents (2002)

Cluster systems are leading architectures for building popular Web sites that have to guarantee scalable services when the number of accesses grows exponentially. The most common Web cluster systems consist of replicated back-end and Web servers and a Web switch that routes client requests among the nodes. We propose a new scheduling policy, namely Multi-Class Round Robin (MC-RR) for Web switches operating at layer 7 of the OSI protocol stack. Its goal is to improve load sharing in recent Web clusters that provide multiple services such as static and dynamic information. We demonstrate through a wide set of simulation experiments that other dispatching policies aiming to improve locality in server caches give best results for traditional Web publishing sites providing static information and some simple database searches. On the other hand, when we consider more recent Web sites providing highly dynamic services, MC-RR is much more effective than state-of-the-art Web switch policies. The proposed algorithm has the additional benefit of guaranteeing stable results because its performance does not depend on several parameters that are very hard to tune in highly variable Web systems.
Activation of coagulation and deep vein thrombosis after bone marrow harvesting and insertion of a Hickman-catheter in ABMT patients with malignant lymphoma. (1996)

Evidence of activation of coagulation was sought in serial plasma samples from 25 ABMT candidates with malignant lymphoma admitted for bone marrow harvesting: 10 females and 15 males, median age 41 years (range 27-58 years). Nineteen patients had non-Hodgkin's lymphoma (NHL) and six had Hodgkin's disease. Of those with NHL, 14 had high-grade and five low- grade disease. The plasma levels of markers of activation (prothrombin fragment 1 + 2, thrombin-antithrombin complexes, fibrinopeptide A and fibrinmonomers) increased significantly (P < 0.001) in association with harvesting. Except for fibrinopeptide A, the indicators of activation were still significantly elevated 24 h after marrow aspiration. Beta-thromboglobulin, a marker of the platelet release reaction, also increased significantly (P < 0.01). Four out of nine patients in whom a long-term central venous catheter was inserted just after marrow aspiration, developed catheter-related deep vein thrombosis, verified venographically, shortly after harvesting. These results suggest that patient with malignant lymphoma undergoing marrow harvesting develop a hypercoagulable state, and that insertion of a central intravenous catheter immediately after marrow harvesting should be avoided to prevent the development of symptomatic deep vein thrombosis.
ChemInform Abstract: Thermal Generation of Carotenoid‐Derived Compounds (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highly-linear FM transmitter for mobile application in 65nm CMOS (2011)

An FM frequency synthesizer and antenna driver with >;63dB SNR, <;0.1% THD, and -101dBc out-of band emissions at 124 dBμV output swing in 65 nm digital CMOS is described. The optimized FLL incorporates a DCO with a highly linear capacitor array and flicker noise reduction techniques. Cascaded filtering and a segmented driver improve efficiency and tuning range with minimal high-order distortion.
Comparative Clinical Bioavailability of Delta-9-THC from a Suppository Formulation Containing the Hemisuccinate Ester vs. an Oral Preparation (1993)

s Third International Congress of Therapeutic Drug Monitoring and Clinical Toxicology: PDF Only
29.1: Invited Paper : Recent Progress in Light‐Emitting Polymers for Full Color OLEDs (2008)

Abstract We have significantly improved the efficiency, lifetime and hue of red, green, blue (RGB) light‐emitting polymers (LEPs) through intensive studies on degradation and charge balance in polymer organic light‐emitting diodes (OLEDs). The degradation of LEPs during device operation is shown to result from decreased emissive material fluorescence efficiency and a loss of charge‐carrier balance. Laser photolysis results show that low‐energy sites are generated in the LEP during driving, leading to the quenching of blue and green emission, but not red emission. Charge carrier balance also shifts due to decreased electron injection compared with hole injection. Taking these degradation mechanisms, we have focused on copolymerization of various functional units to stabilize the photoluminescence (PL) intensity and the balance of charge carriers. In this paper, we present the degradation mechanism and performance of our latest RGB LEPs.
Signs of life detection using wireless passive radar (2016)

Non-contact devices for monitoring signs of life have attracted a lot of attention in recent years for applications in security, emergency and disaster situations. Current devices however, generally utilize bespoke active systems to transmit large bandwidth signals. In this paper, a real-time phase extraction method based on passive Wi-Fi radar is proposed for detecting the chest movements associated with a person breathing. Since the monitored movements are of low amplitude and small Doppler shift, this method uses the phase variation rather than traditional range-Doppler processing. The processing is based on time domain cross correlation, with the addition of a Hampel filter for outlier detection and removal. In this paper the basic passive Wi-Fi model and limitations of traditional cross ambiguity function for signs of life detection are first introduced. The phase extraction method is then described followed by experimental results and analysis. Detection of breathing for a stationary person is shown in both in-room and through wall scenarios using both the Wi-Fi beacon and data transmissions. This is believed to be the first demonstration of signs of life detection using phase extraction in passive radar and extends the capability of such systems into a wide range of new applications.
Micropropagation: technology and application. (1990)

Micropropagation.- Laboratory design.- Problems in tissue culture: culture contamination.- Vitrification: morphological and physiological disorders of in vitro plants.- Acclimatization of micropropagated plants to the greenhouse and field.- Post culture behavior: genetic and epigenetic effects and related problems.- Economic considerations.- Marketing of micropropagated plants.- Commercial micropropagation in Western Europe and Israel.- Commercial production in Poland and other Eastern European countries.- Commercial micropropagation in North America.- Commercial micropropagation in Asia.- Commercial production in Australia and New Zealand.- Commercial micropropagation in South and Central America.- Micropropagation and plant tissue culture in developing countries of Africa.- Ornamentals.- Micropropagation of temperate zone fruit and nut crops.- Micropropagation of tropical and subtropical fruits.- Micropropagation of vegetable crop species.- Applications of micropropagation for agronomic crops.- Application of micropropagation to forestry.- Estate crops.- Automation.- Future technologies: model-reference control systems for the scale-up of embryogenesis and polyembryogenesis in cell suspension cultures.- Application of bioreactors in plant propagation.- Micropropagation under photoautotrophic conditions.- List of contributors.- Index of species.- Index of subjects.
Practical Algorithms for Programmers (1995)

From the Publisher:
This book focuses on practical, immediately usable code with extensive discussion of portability and implementation-specific details. The authors present the useful but rarely discussed algorithms for phonetic searches, date and time routines (to the year AD 1), B-trees and indexed files, data compression, arbitrary precision arithmetic, checksums and data validation, as well as the most comprehensive coverage available of search routines, sort algorithms, and data structures. Practical Algorithms for Programmers requires only a working knowledge of C and no math beyond basic algebra. The source code is ANSI-compliant and has been tested and run under UNIX and on compilers from Borland, Microsoft, and Watcom.
ChemInform Abstract: Radical Cyclization of N‐(Cyclohexenyl)acrylamides: Synthesis of Bicyclic N‐Heterocycles. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alter: Leveraging Breakable Dependences for Parallelization (2016)

For decades, compilers have relied on dependence analysis to determine the legality of their transformations. While this conservative approach has enabled many robust optimizations, when it comes to parallelization there are many opportunities that can only be exploited by changing or re-ordering the dependences in the program. This paper presents ALTER: a system for identifying and enforcing parallelism that violates certain dependences while preserving overall program functionality. Based on programmer annotations, ALTER exploits new parallelism in loops by reordering iterations or allowing stale reads. ALTER can also infer which annotations are likely to benefit the program by using a test-driven framework. Our evaluation of ALTER demonstrates that it uncovers parallelism that is beyond the reach of existing static and dynamic tools. Across a selection of 12 performance-intensive loops, 9 of which have loop-carried dependences, ALTER obtains an average speedup of 2.0x on 4 cores.
Necrotic Enteritis-Derived Clostridium perfringens Strain with Three Closely Related Independently Conjugative Toxin and Antibiotic Resistance Plasmids (2011)

ABSTRACT The pathogenesis of avian necrotic enteritis involves NetB, a pore-forming toxin produced by virulent avian isolates of Clostridium perfringens type A. To determine the location and mobility of the netB structural gene, we examined a derivative of the tetracycline-resistant necrotic enteritis strain EHE-NE18, in which netB was insertionally inactivated by the chloramphenicol and thiamphenicol resistance gene catP . Both tetracycline and thiamphenicol resistance could be transferred either together or separately to a recipient strain in plate matings. The separate transconjugants could act as donors in subsequent matings, which demonstrated that the tetracycline resistance determinant and the netB gene were present on different conjugative elements. Large plasmids were isolated from the transconjugants and analyzed by high-throughput sequencing. Analysis of the resultant data indicated that there were actually three large conjugative plasmids present in the original strain, each with its own toxin or antibiotic resistance locus. Each plasmid contained a highly conserved 40-kb region that included plasmid replication and transfer regions that were closely related to the 47-kb conjugative tetracycline resistance plasmid pCW3 from C. perfringens . The plasmids were as follows: (i) a conjugative 49-kb tetracycline resistance plasmid that was very similar to pCW3, (ii) a conjugative 82-kb plasmid that contained the netB gene and other potential virulence genes, and (iii) a 70-kb plasmid that carried the cpb2 gene, which encodes a different pore-forming toxin, beta2 toxin. IMPORTANCE The anaerobic bacterium Clostridium perfringens can cause an avian gastrointestinal disease known as necrotic enteritis. Disease pathogenesis is not well understood, although the plasmid-encoded pore-forming toxin NetB, is an important virulence factor. In this work, we have shown that the plasmid that carries the netB gene is conjugative and has a 40-kb region that is very similar to replication and transfer regions found within each of the sequenced conjugative plasmids from C. perfringens . We also showed that this strain contained two additional large plasmids that were also conjugative and carried a similar 40-kb region. One of these plasmids encoded beta2 toxin, and the other encoded tetracycline resistance. To our knowledge, this is the first report of a bacterial strain that carries three closely related but different independently conjugative plasmids. These results have significant implications for our understanding of the transmission of virulence and antibiotic resistance genes in pathogenic bacteria.