gebhart/patrepeval huggingface dataset:
Large Scale Genomic Instability as an Additive Prognostic Marker in Early Prostate Cancer (2009)

Background : The clinical outcome for the individual prostate cancer patient is often difficult to predict, due to lack of reliable independent prognostic biomarkers. We tested DNA ploidy as a prognostic factor for clinical outcome in 186 patients treated with radical prostatectomy. Methods : DNA ploidy was measured using an automatic image cytometry system and correlated with preoperative PSA, age at surgery, Mostofi grade, surgical margins and Gleason score. Results : The mean follow up time after operation was 73.3 months (range 2–176 months). Of the 186 prostatectomies, 96 were identified as diploid, 61 as tetraploid and 29 as aneuploid. Twenty-three per cent, 36% and 62% of the diploid, tetraploid and aneuploid cases respectively, suffered from relapse during the observation time. DNA ploidy, Gleason score, Mostofi grading, surgical margins and preoperative PSA were all significant predictors of relapse in a univariate analysis. On multivariate analysis, only Gleason score and DNA ploidy proved to be independently predictors of disease recurrence. Furthermore, among the 68 cases identified with Gleason score 7, DNA ploidy was the only significant predictor of disease recurrence. Conclusion : Our data suggest that DNA ploidy should be included as an important additive prognostic factor for prostate cancer, especially for patients identified with Gleason score 7 tumours.
Pengaruh Lingkungan Keluarga Dan Motivasi Belajar Terhadap Minat Menjadi Guru Pada Mahasiswa Program Studi S1 Pendidikan Ekonomi (2020)

Penelitian untuk mengetahui dan menganalisis pengaruh lingkungan keluarga dan motivasi belajar terhadap minat menjadi guru. Penelitian kuantitatif dengan teknik pengumpulan data menggunakan kuesioner, wawancara dan dokumentasi. Populasi dan sampel dalam penelitian ini total keseluruhan 81 mahasiswa dengan menggunakan sampel jenuh. Teknik analisis data menggunakan analisis regresi linier berganda yang sebelumnya telah di uji asumsi klasik. Dilihat secara parsial, hasil uji regresi linier berganda untuk variabel lingkungan keluarga memberikan pengaruh sebesar 0,616 atau sebesar 52,55% dan untuk variabel motivasi belajar memberikan pengaruh sebesar 0,556 atau sebesar 47,45%. Dan secara simultan, nilai R Square sebesar 0,524 atau sebesar 52,4%, sisanya 48,6% dipengaruhi variabel lain diluar variabel penelitian ini.
Biological length scale topography enhances cell-substratum adhesion of human corneal epithelial cells (2004)

The basement membrane possesses a rich 3-dimensional nanoscale topography that provides a physical stimulus, which may modulate cell-substratum adhesion. We have investigated the strength of cell-substratum adhesion on nanoscale topographic features of a similar scale to that of the native basement membrane. SV40 human corneal epithelial cells were challenged by well-defined fluid shear, and cell detachment was monitored. We created silicon substrata with uniform grooves and ridges having pitch dimensions of 400-4000 nm using X-ray lithography. F-actin labeling of cells that had been incubated for 24 hours revealed that the percentage of aligned and elongated cells on the patterned surfaces was the same regardless of pitch dimension. In contrast, at the highest fluid shear, a biphasic trend in cell adhesion was observed with cells being most adherent to the smaller features. The 400 nm pitch had the highest percentage of adherent cells at the end of the adhesion assay. The effect of substratum topography was lost for the largest features evaluated, the 4000 nm pitch. Qualitative and quantitative analyses of the cells during and after flow indicated that the aligned and elongated cells on the 400 nm pitch were more tightly adhered compared to aligned cells on the larger patterns. Selected experiments with primary cultured human corneal epithelial cells produced similar results to the SV40 human corneal epithelial cells. These findings have relevance to interpretation of cell-biomaterial interactions in tissue engineering and prosthetic design.
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. (2001)

Estrogen can increase insulin-like growth factor-I receptor (IGF-IR) and insulin receptor substrate-1 (IRS-1) expression, two key components of IGF-I-mediated signaling. The result is sensitization of breast cancer cells to IGF-I and synergistic growth in the presence of estrogen and IGF-I. We hypothesized that loss of estrogen receptor alpha (ERalpha) would result in reduced IGF-mediated signaling and growth. To test this hypothesis, we examined IGF-I effects in MCF-7 breast cancer cell sublines that have been selected for loss of ERalpha (C4 and C4-12 cells are ERalpha-negative) by long-term estrogen withdrawal. C4 and C4-12 cells had reduced IGF-IR and IRS-1 mRNA and protein expression (compared with MCF-7 cells) that was not inducible by estrogen. Furthermore, C4 and C4-12 cells showed reduced IGF-I signaling and failed to show any growth response to either estrogen or IGF-I. To prove that loss of IGF and estrogen-mediated signaling and growth was a consequence of loss of ERalpha, we re-expressed ERalpha in C4-12 cells by stable transfection with HA-tagged ERalpha. Three independent C4-12 ERalpha-HA clones expressed a functional ERalpha that (a) was down-regulated by estrogen, (b) conferred estrogen-induction of cyclin D1 expression, and (c) caused estrogen-mediated increase in the number of cells in S phase. All of the effects were completely blocked by antiestrogens. Interestingly, ERalpha-HA expression in C4-12 cells did not restore estrogen induction of progesterone receptor expression. However, ERalpha-positive C4-12 cells now exhibited estrogen-induction of IGF-IR and IRS-1 levels and responded mitogenically to both estrogen and IGF-I. These data show that ERalpha is a critical requirement for IGF signaling, and to our knowledge this is the first report of functional ERalpha expression that confers estrogen-mediated growth of an ER-negative breast cancer cell line.
3D bio-modelling of ulcer lesions for disease diagnostic (2008)

This paper describes a non-invasive technology to allow measurement and monitoring of nonhealing\n\nchronic wounds. These lesions significantly impair the life quality of millions of people.\n\nTheir diagnosis and treatment constitute a challenge in patient rehabilitation, since a variety of\n\nclassification systems is available and highly skilled and experienced personnel is required. In\n\nthis context, the proposed system involves the integration of a 3D scanner with a thermal\n\nimager, permitting the acquisition of geometrical data, which include both chromatic texture and\n\ntemperature information. A prototype tool for the automatic detection and measurement of\n\ndamaged skin areas has been developed by segmenting both color and thermal images. The\n\ndescribed methodology, which constitutes an objective and consistent approach to automated\n\ndiagnosis, significantly increases the efficiency and monitoring capabilities of medical experts.\n\nThe technology has been clinically experienced in medical environments. The physicians\n\nconfirmed that this prototype tool can be a valuable support in their work improving the quality of\n\ndisease diagnosis and prediction of healing.
Ion Channels Meet Auxin Action (2006)

The regulation of cell division and elongation in plants is accomplished by the action of different phytohormones. Auxin as one of these growth regulators is known to stimulate cell elongation growth in the aerial parts of the plant. Here, auxin enhances cell enlargement by increasing the extensibility of the cell wall and by facilitating the uptake of osmolytes such as potassium ions into the cell. Starting in the late 1990s, the auxin regulation of ion channels mediating K+ import into the cell has been studied in great detail. In this article we will focus on the molecular mechanisms underlying the modulation of K+ transport by auxin and present a model to explain how the regulation of K+ channels is involved in auxin-induced cell elongation growth.
Quantitative evaluation of two-photon calcium imaging modalities for high-speed volumetric calcium imaging in scattering brain tissue (2017)

Abstract Considerable efforts are currently being devoted to enhance the speed, spatial resolution and the size of the 3D sample volumes in which calcium imaging methods can capture neuronal network activity in different model systems. In the mammalian brain, tissue scattering severely limits the use of parallel acquisition techniques such as wide-field imaging and, as a consequence, methods based on two-photon point-scanning (2PM) have become the method of choice. However, 2PM faces severe restrictions due to technical limitations such as scan speed, laser power, and those related to the fluorescent probes, calling for conceptually new approaches to enhance the performance of two-photon calcium imaging schemes. Here we provide a detailed quantitative evaluation and comparison of different excitation/detection modalities from the perspective of detecting neuronal activity that are based on different point-spread functions (PSF), laser repetition rates and sampling strategies. We demonstrate the conditions for which imaging speed and signal-to-noise ratio are optimized for a given average power. Our results are based on numerical simulations which are informed by experimentally measured parameters and show that volumetric field of view and acquisition speed can be considerably improved compared to traditional 2PM schemes by a holistic optimization approach.
Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients (2015)

At a given level of serum cholesterol, patients with T2D have an increased risk of developing atherosclerosis compared with nondiabetic subjects. We hypothesized that T2D patients have an increased interstitial fluid (IF)-to-serum gradient ratio for LDL, due to leakage over the vascular wall. Therefore, lipoprotein profiles in serum and IF from 35 T2D patients and 35 healthy controls were assayed using fast performance liquid chromatography. The IF-to-serum gradients for VLDL and LDL cholesterol, as well as for apoB, were clearly reduced in T2D patients compared with healthy controls. No such differences were observed for HDL cholesterol. Contrary to our hypothesis, the atherogenic VLDL and LDL particles were not increased in IF from diabetic patients. Instead, they were relatively sparser than in healthy controls. The most probable explanation to our unexpected finding is that these lipoproteins are more susceptible to retainment in the extravascular space of these patients, reflecting a more active uptake by, or adhesion to, tissue cells, including macrophages in the vascular wall. Further studies are warranted to further characterize the mechanisms underlying these observations, which may be highly relevant for the understanding of why the propensity to develop atherosclerosis is increased in T2D.
Clinical Thermofiltration: Initial Application (2000)

Guest Editor's Introduction: This paper was submitted for publication in June 1985 and published in the “Thought and Progress” section of Artificial Organs, Vol. 9, No. 4, 1985, pages 425–427. The first clinical thermofiltration procedures (plasma filtration near and above normal physiologic temperature) were performed on a secondary hypercholesterolemia patient. The intent of this filtration scheme is the selective removal of low density lipoprotins (LDL) and maintenance of high density limpoproteins (HDL) and other essential plasma proteins including albumin. The EVAL 4A filter, at a filtration temperature of 37°C, was selected for on‐line thermofiltration. The sieving coefficients of LDL + very low density lipoproteins (VLDL) cholesterol, HDL cholesterol, and albumin were 0.02, 0.75, and 0.78, respectively. These results were comparable to in vitro filtration tests using the plasma of the same patient. This system is simple to apply and does not require replacement solution. Compared with plasma exchange, a high return of HDL and other essential plasma solutes can be returned to the patient by this method. Abstract: The first clinical thermofiltration procedures (plasma filtration near or above normal physiologic temperature) were performed on a secondary hypercholesterolemia patient. The intent of this filtration scheme is the selective removal of low density lipoproteins (LDL) and maintenance of high density lipoproteins (HDL) and other essential plasma proteins including albumin. The EVAL 4A filter, at a filtration temperature of 37°C, was selected for on‐line thermofiltration. The sieving coefficients of LDL + very low density lipoproteins (VLDL) cholesterol, HDL cholesterol, and albumin were 0.02, 0.75, and 0.78, respectively. These results are comparable to in vitro filtration tests using the plasma of the same patient. This system is simple to apply and does not require replacement solution. Compared with plasma exchange, a high return of HDL and other essential plasma solutes can be returned to the patient by this method.
On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging (2007)

This paper presents a new manufacturing method to generate monodisperse microbubble contrast agents with polydispersity index (sigma) values of <2% through microfluidic flow-focusing. Micron-sized lipid shell-based perfluorocarbon (PFC) gas microbubbles for use as ultrasound contrast agents were produced using this method. The poly(dimethylsiloxane) (PDMS)-based devices feature expanding nozzle geometry with a 7 microm orifice width, and are robust enough for consistent production of microbubbles with runtimes lasting several hours. With high-speed imaging, we characterized relationships between channel geometry, liquid flow rate Q, and gas pressure P in controlling bubble sizes. By a simple optimization of the channel geometry and Q and P, bubbles with a mean diameter of <5 microm can be obtained, ideal for various ultrasonic imaging applications. This method demonstrates the potential of microfluidics as an efficient means for custom-designing ultrasound contrast agents with precise size distributions, different gas compositions and new shell materials for stabilization, and for future targeted imaging and therapeutic applications.
Upper Bounding the Deletion Channel Capacity by Auxiliary Memoryless Channels (2009)

We present two upper bounds on the capacity of the binary deletion channel. Both bounds are obtained by providing the transmitter and the receiver with genie-aided information on suitably-defined random processes. Since the closed-form expressions of the proposed bounds involve infinite series, we also introduce provable inequalities that lead to more manageable results. For most values of the deletion probability, these bounds improve the existing ones and significantly narrow the gap with the available lower bounds.
Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies (2019)

In contrast to prior studies, we demonstrate for the first time that liraglutide treatment, administered over a longer period at the highest doses approved for obesity, does not alter brain activation in response to food cues. A counter-regulatory increase in reward-related OFC activation in response to food cues can be observed when neuroimaging data are controlled for BMI changes, indicating changes in CNS that could lead to later plateaus of weight loss. These data point to a promising focus for additional interventions which, by contributing to the CNS reward system, could provide tangible benefits in reversing the plateauing phenomenon and promoting further weight loss.
Non-asymptotic confidence regions for model parameters in the presence of unmodelled dynamics (2007)

This paper deals with the problem of constructing confidence regions for the parameters of truncated series expansion models. The models are represented using orthonormal basis functions, and we extend the “Leave-out Signdominant Correlation Regions” (LSCR) algorithm such that non-asymptotic confidence regions can be constructed in the presence of unmodelled dynamics. The constructed regions have guaranteed probability of containing the true parameters for any finite number of data points. The algorithm is first developed for FIR models and then generalized to orthonormal basis functions expansions. The usefulness of the developed approach is demonstrated for Laguerre models in a simulation example.
Solid-State Emissive Triarylborane-Based [2.2]Paracyclophanes Displaying Circularly Polarized Luminescence and Thermally Activated Delayed Fluorescence (2018)

New types of [2.2]paracyclophane derivatives, g-BNMe<sub>2</sub>-Cp and m-BNMe<sub>2</sub>-Cp, in which electron-donating NMe<sub>2</sub> and the electron-accepting BMes<sub>2</sub> are introduced at the pseudo -gem and pseudo -meta positions, were designed and synthesized. The efficient through-space charge transfer enables the intense fluorescence with thermally activated delayed fluorescence characteristics. The quantum yields are up to 0.72 and 0.39 in cyclohexane. In addition, no significant fluorescence quenching was observed in the solid state with fluorescence quantum yields of powder up to 0.53 and 0.33. Moreover, the enantiomerically pure forms of g-BNMe<sub>2</sub>-Cp exhibit strong CPL signals with g<sub>lum</sub> up to 4.24 × 10<sup>-3</sup>.
Cellulases and hemicellulases of the anaerobic fungus Piromyces constitute a multiprotein cellulose-binding complex and are encoded by multigene families (1995)

Abstract More than 80% of the extracellular Avicelase, endoglucanase, xylanase and mannanase activities of the anaerobic fungus Piromyces were associated with a cellulose-binding complex. The complex was composed of at least 10 polypeptides ranging in size from 190 kDa to 50 kDa, and contained numerous endoglucanases, xylanases and mannanases. Multiple genes encoding each of these activities were isolated from an expressing cDNA library.
Enhancing the Bluetooth Service Discovery Protocol (2001)

Bluetooth Service Discovery Protocol (SDP) enables a client application on a device to discover information about services on other Bluetooth devices. Every service is represented by a profile, identified by a 128-bit Universally Unique Identifier (UUID). A match occurs on a peer device if and only if at least one UUID specified by the client is contained in one or more of its service records. We believe that the advantages of UUID-based matching to support service discovery are restricted to ad-hoc Bluetooth networks consisting of resource constrained devices. The more common case for applications using Bluetooth networks, is the existence of one or more resource rich devices (e.g., the Compaq iPAQ) in the network. This calls for a matching mechanism that uses semantic information associated with services and attributes to decide the success or failure of a query. We present an enhanced version of Bluetooth SDP that supports semantic matching and provides service registration. We evaluate the performance of this enhanced version of SDP and compare it with regular SDP. We show that enhanced SDP performs comparably to regular SDP in terms of Round Trip Time and matching time.
Panorama Científico da Busca para o Tratamento da Leishmaniose (2010)

Anualmente, a leishmaniose, uma doença infecto-parasitária crônica, acomete milhares de pessoas em todo o mundo. Mesmo assim, é uma das doenças mais negligenciadas. A comunidade científica constantemente se esforça para alcançar êxito na descoberta de novas moléculas que possam originar medicamentos menos tóxicos e mais eficazes, novos métodos para diagnóstico, e novas vacinas. No Brasil, a doença atinge, predominantemente, as regiões Norte e Nordeste, mas dados epidemiológicos aqui apresentados, mostram o crescimento da incidência e da prevalência da leishmaniose no município do Rio de Janeiro. Com o objetivo de dimensionar as pesquisas em busca de novos tratamentos para a leishmaniose, foram feitos levantamentos das publicações, patentes nacionais e internacionais, além do número de pesquisadores brasileiros inseridos nessa busca.
A position sensorless control for IPMSM at low speed based on current response at zero voltage vector without any additional signal injection (2016)

This paper describes a novel rotor position estimation method for IPMSM at low speed without any signal injection. The basic idea of proposed method is using derivative currents in zero vector state, because the derivative currents include the rotor position information. This paper presents the relationship between rotor position and current response at zero vector mathematically. By this relationship, a parameter sensitivity could also be deduced. Then, the validity of proposed method is demonstrated by experiments.
Synthesis and structure-activity relationships of 3-(2-imidazolyl)thiomethyl cephalosporins. (1989)

The synthesis and structure-activity relationships of a series of 3-(2-imidazolyl)thiomethyl cephalosporins are described. Among the compounds, 7 beta-[2-(2-amino-1,3-thiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3- [(4,5-dicarboxyimidazol-2-yl)thiomethyl]-3-cephem-4-carboxylic acid (1) exhibited potent activity against both Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa. We also estimated lipophilicity of the compounds from the chromatographic log k' value of reversed-phase HPLC. The relationship between lipophilicity and biological activity showed that compound 1 had the most suitable lipophilicity.
Selective p-type Doping of GaN:Si by Mg Ion Implantation and Multicycle Rapid Thermal Annealing (2015)

Selective p-type doping of Si-doped GaN by Mg ion implantation and multicycle rapid thermal annealing (MRTA) is demonstrated. Samples of GaN were capped by AlN and annealed in N2 overpressure at temperatures up to 1330°C. MRTA resulted in a lower resistivity films, compared to a conventionally-annealed reference sample. Mg acceptor activation for the MRTA annealed sample was calculated using a two-layer corrected Hall method to be about 1% at room temperature. Low temperature photoluminescence revealed donor-acceptor bound electron-hole pair recombination near 3.2 eV, indicating activation of Mg upon MRTA annealing.
Bildung von Metall‐Metall‐Mehrfachbindungen zwischen zwei Wolfram‐Calix[4]aren‐Einheiten durch reduktive Kupplung (1997)

Eine Wolfram‐Wolfram‐Doppel‐ bzw. ‐Dreifachbindung enthalten die W 2 ‐Komplexe 1 (Strukturbild rechts, Substituenten an den Calixareneinheiten teilweise weggelassen) und 2 , die durch reduktive Dimerisierung des entsprechenden einkernigen Komplexes mit zwei Chloridliganden zugänglich sind. In 1 befinden sich die beiden Na + ‐Ionen in den Calixarenhohlräumen, in 2 verbrücken sie die beiden Calixareneinheiten. py = Pyridin. magnified image equation image
Computer-aided diagnosis of proliferative diabetic retinopathy (2012)

Monitoring the openness of the major temporal arcade (MTA) and how it changes over time could facilitate improved diagnosis and timely treatment of proliferative diabetic retinopathy (PDR). We present methods for user-guided modeling and measurement of the openness of the MTA based on a form of the generalized Hough transform for the detection of parabolas, and to compare it with a method of arcade angle measurement. The methods, implemented via a graphical user interface, were tested with retinal fundus images of 10 normal individuals and 15 patients with PDR. The results using the openness parameters of single- and dual-parabolic models as well as the arcade angle measurements indicate areas under the receiver operating characteristics of A(z)= 0.94, 0.87, and 0.84, respectively. The proposed methods should facilitate improved quantitative analysis of the architecture of the MTA, as well as assist in detection, diagnosis, and improved treatment of PDR.