gebhart/patrepeval huggingface dataset:
Drug delivery and toxicity of adjuvant chemotherapy for non-small cell lung cancer (NSCLC): Washington University experience (2007)

To the EditorSeveral randomized trials utilizing platinum baseddoublet regimens have shown a survival benefit foradjuvant chemotherapy for non-small cell lungcancer (NSCLC) [1 5]. Adjuvant chemotherapy isincreasingly used in the USA following the publica-tions of the above mentioned studies. To our knowl-edge, there have been no reports on delivery andtoxicity of adjuvant chemotherapy for NSCLC out-side the clinical trial setting. We performed an auditof all patients with NSCLC who underwent surgicalresection and received adjuvant chemotherapy atWashington University School of Medicine betweenJanuary 2003 and December 2005. A total of 40patients were identified to have received adjuvantchemotherapy for NSCLC. The median age in thisgroup was 57 years (range 40 73). The majority ofpatients (68%) were Caucasian with African Amer-icans representing 27% of the population. Men andwomen were represented in equal proportions. Over90% of the patients had a favorable (0 1) Adultcomorbidity evaluation score-27 (ACE-27) at thetime of surgery. The median time from surgery tothe start of cycle 1 of chemotherapy was 49 (range16 118) days. Cisplatin with docetaxel was the mostfrequently used (43%) adjuvant chemotherapy regi-men during the study period followed by carboplatinand paclitaxel (17%), carboplatin and docetaxel(17%), and carboplatin and gemcitabine (15%).Of the 40 patients, 16 (40%) had received theintended dose (all the scheduled cycles without anydose modifications or delays). Seven patients (18%)did not receive the planned cycles of chemotherapywhile 21 (53%) patients had dose reductions and3 (8%) had dose delays (Table I). Adjuvant therapywas discontinued without completion of the sched-uled number of cycles due to toxicities in 6 (15%).Seventeen patients (42%) reported grade 3/4 toxi-cities, most commonly neutropenia and fatigue.Neutropenic fever occurred in two patients. Therewere no deaths resulting from adjuvant chemo-therapy.Most of the current data regarding delivery andtolerability of adjuvant chemotherapy for NSCLCare obtained from prospective studies [4,6 9] cis-platin and docetaxel, 11 (65%) received full doses ofchemotherapy without dose reduction, delays oromission. Grade 3/4 neutropenia in our studyoccurred in 25% of the patients as opposed to 36%in the CALGB 9633 trial, 17.5% (grade 4 alone) inthe IALT trial and 85% in the ANITA trial [2,4,7].This report provides the first ‘‘real life’’ experienceregarding the chemotherapy delivery and toxicity inpatients with resected non-small cell lung canceroutside the context of clinical trials.
Supplementary Figure 4 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity (2023)

Supplementary Figure 4 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Endocytosis: Relation to Capping and Cell Locomotion (1984)

Most mammalian cells, such as fibroblasts, continuously internalize part of their surface membrane by endocytosis, and then later return it to the cell surface. This cyclical process is initiated by coated pits in the plasma membrane. These pits collect specific receptors plus lipid for internalization, but exclude other proteins. On a motile cell, the sites of endocytosis (randomly located on the cell) and those of membrane return (located at the front of the cell) are not coincident. This causes a bulk flow of lipid plus receptors in the plasma membrane, away from the front of the cell. Large objects on the cell surface are swept to the rear of the cell by this flow, a process called capping. Cells may use this polarized endocytic cycle to move.
Mucosal Malignant Melanoma of the Paranasal Sinuses (1992)

We report a case of primary malignant melanoma arising in the mucosa of the nose and paranasal sinuses. Clinical presentation and course of this rare type of melanoma are described, and the surgical management is discussed.
Compatibility in Ozsvath-Szabo's bordered HFK via higher representations (2022)

We equip the basic local crossing bimodules in Ozsváth-Szabó's theory of bordered knot Floer homology with the structure of 1-morphisms of 2-representations, categorifying the $U_q(\mathfrak{gl}(1|1)^+)$-intertwining property of the corresponding maps between ordinary representations. Besides yielding a new connection between bordered knot Floer homology and higher representation theory in line with work of Rouquier and the second author, this structure gives an algebraic reformulation of a ``compatibility between summands'' property for Ozsváth-Szabó's bimodules that is important when building their theory up from local crossings to more global tangles and knots.
A tale of two houses: the human dimension of demand response enabling technology from a case study of an adaptive wireless thermostat. (2008)

Demand response—the management of customer electricity demand in response to supply—has emerged as a promising means of increasing grid reliability by reducing peak demand. One potential technology to enable residential Demand Response (DR) is a Programmable Communicating Thermostat (PCT) that receives price signals from the electrical utility. However, several issues preclude the widespread adoption of this technology and policy. One is the poor adoption and energy-conserving performance of a similar technology and policy—the programmable setback thermostat. Another is lukewarm customer response to residential DR air conditioning cycling programs. Finally, financial incentive alone may not suffice to persistently reduce peak electricity consumption.A team at UC Berkeley developed an alternative model for a residential demand response enabling technology, called the Demand Response Electrical Appliance Manager (DREAM). The DREAM system acts as both an intelligent thermostat and in-home energy display. DREAM consists of a wireless network of data sensors, appliance actuators and a central controller that can communicate variable price signals. We tested the DREAM in two houses in the summer of 2007 for six weeks. The DREAM controlled the HVAC system, monitored electricity from appliances, sensed temperature and occupancy, and displayed temperature and energy consumption. This paper discusses potential issues for DR policy and technology, and describes potential solutions in improving user adoption.
Use of elemental sulphur as an acidifying soil amendment for Brassica napus cultivation (2015)

Elemental sulphur is applied to alkaline soils as an acidifying material in order to improve nutrient availability and soil productivity. The oil industry extracts crude oils with ever higher concentrations of sulphur (S) that should not be released to the atmosphere and can be recovered by desulphurisation processes. The elemental S thus obtained has diverse applications, such as the manufacture of sulphuric acid, retreaded tyres, fungicides and acidifying agents. When used as a soil acidifying agent, S undergoes an oxidation process that depends on several soil-related factors: temperature, aeration, texture and organic matter content. The most important parameter appears to be the particle size of the S form applied to the soil. This study investigated the acidifying effects of two forms of elemental S, derived from an oil refinery, on an alkaline soil planted with oilseed rape. A trial was established in 300 L containers maintained outdoors in a site that received more than 1000 mm of precipitation during the study period, between October and the end of April. The treatments consisted of powdered (&amp;lt;0.5 mm) S at a dose of 1.5 t ha&lt;sup&gt;-1&lt;/sup&gt;, and sieved (0.5-2 mm) S at doses of 3 and 5 t ha&lt;sup&gt;-1&lt;/sup&gt;. Control soils were not treated with sulphur. The effects of the different treatments were studied by analysing leachates collected after every episode of rain during the crop cycle, foliar analysis of the crop produced, quantification of seed production and oil yield, and, finally, analysis of aqueous extracts of the soil obtained after harvesting the crop. The results obtained show that under the study conditions, sieved S (0.5-2 mm) was at least as effective as powdered S as a treatment for acidifying the alkaline calcareous soil used in the study. The sieved form offers two advantages relative to the powdered form: it requires less grinding and its storage and distribution in the field are simpler because the material does not disperse in the air (as the particles are larger) and is not explosive.
The participation of phytochrome in the signal transduction pathway of salt stress responses inMesembryanthemum crystallinumL. (1996)

Continuous irradiation of Mesembryanthemum crystallinum plants with light of equal amounts of photosynthetically active radiation, but widely different red:far red ratios was used to intervene in phytochrome-mediated signal transduction pathways in the presence and absence of salt stress. Light with a low ratio of red:far red (in contrast to light with a high ratio of red:far red), caused induction of PEP carboxylase activity, accumulation of the CAM isoform of PEP carboxylase, and the accumulation of malate anion. Taking these as indicators of CAM induction it is concluded that phytochrome can participate in the signal transduction pathway leading to CAM in M. crystallinum. A low ratio of red: far red light acted synergystically with salt stress in the induction of these CAM indicators. The simplest interpretation of this interaction is that the phytochrome-mediated effects and salt stress effects acted on the same signal transduction pathway. The accumulation of pinitol was also increased by light with a low ratio of red:far red, consistent with the existence of a stress syndrome in M. crystallinum which utilizes a common transduction pathway. A low ratio of red:far red light induced a strong shade avoidance response and, compared to light with a high red:far red ratio, modified chlorophyll content and betacyanin pigment complement. Plants grown in light with a low ratio of red:far red flowered earlier than plants grown in light with a high red:far red ratio. It is concluded that phytochrome can participate in the signal transduction pathway leading to the induction of both CAM and the processes which result in pinitol accumulation and pigmentation in M. crystallinum, as well as in the mediation of shade avoidance and flowering responses.
ns or fs pulsed laser ablation of a bulk InSb target in liquids for nanoparticles synthesis (2016)

International audience
Deep-based Ingredient Recognition for Cooking Recipe Retrieval (2016)

Retrieving recipes corresponding to given dish pictures facilitates the estimation of nutrition facts, which is crucial to various health relevant applications. The current approaches mostly focus on recognition of food category based on global dish appearance without explicit analysis of ingredient composition. Such approaches are incapable for retrieval of recipes with unknown food categories, a problem referred to as zero-shot retrieval. On the other hand, content-based retrieval without knowledge of food categories is also difficult to attain satisfactory performance due to large visual variations in food appearance and ingredient composition. As the number of ingredients is far less than food categories, understanding ingredients underlying dishes in principle is more scalable than recognizing every food category and thus is suitable for zero-shot retrieval. Nevertheless, ingredient recognition is a task far harder than food categorization, and this seriously challenges the feasibility of relying on them for retrieval. This paper proposes deep architectures for simultaneous learning of ingredient recognition and food categorization, by exploiting the mutual but also fuzzy relationship between them. The learnt deep features and semantic labels of ingredients are then innovatively applied for zero-shot retrieval of recipes. By experimenting on a large Chinese food dataset with images of highly complex dish appearance, this paper demonstrates the feasibility of ingredient recognition and sheds light on this zero-shot problem peculiar to cooking recipe retrieval.
A robust particle position controller for an electrodynamic chamber (1993)

A novel scheme for robust feedback control of a charged particle in an electrodynamic chamber has been designed and applied. The determination of the particle position is based on photodiode array (PDA) shadowgraphy. A 128 linear PDA is used to measure the trace of the particle. The PDA trace is transferred to a PC computer by a special purpose digitizer. Analog-to-digital conversion is realized by feeding the signal through a hard limiter and measuring the time that corresponds to the shadow and light zones. The designed hardware allows a high sampling rate (7.8 kHz). The obtained position value is used by a PID algorithm to control the particle position. The one-to-one correspondence between the calculated and experimental trajectories allows one to study the system performance by simulation rather than by experiments and to assign the proper controller to the specific application. It is shown that the system is insensitive to extreme variations in particle size.
Quality Control of Tooth Contact of Gear using Infrared Ray Imagery (2007)

We propose a non-contact method using infrared ray thermography for measuring gear tooth contact to focus attention on the heat generated on the tooth surface at meshing. First, the radiation performance of the gear tooth surface and the effect of lubrication oil were investigated. Then, the reliability of this technique was evaluated by comparing with the observation result of tooth contact with komyotan which is traditional red paint for industrial use. Finally, the possibility of evaluating the meshing transmission error was shown. The results show this technique is effective for monitoring the contact pattern and confirming the tooth surface pressure.
IL-4 and T Cells Are Required for the Generation of IgG1 Isotype Antibodies Against Cardiolipin (2002)

Infection with Mycobacterium tuberculosis induces Abs against a vast array of mycobacterial lipids and glycolipids. One of the most prominent lipid Ags recognized is cardiolipin (CL). The kinetics of the generation of anti-CL Abs during infection reveals that IgM titers to CL increase over time. Interestingly, at day 30 postinfection CL-specific IgG1 appears, an isotype usually dependent on T cell help. Using an immunization schedule with CL/anti-CL Ab complexes, which induces antiphospholipid syndrome in mice, we show that the generation of IgG1 to CL requires IL-4 and that optimal production is T cell dependent. IgG1 production to CL was impaired in nude (nu/nu) mice devoid in conventional T cells, but was not affected in mice deficient for either alphabeta TCR(+), gammadelta TCR(+), CD4(+), CD8(+), or NK1.1(+) T cells. We conclude that IgG1 production to CL depends on T cell help and IL-4, which can be provided by different T cell populations. This is the first report that IL-4 is indispensable for the induction of IgG1 Abs to lipid Ags.
Generation of Precise Reference Pressures Up to 15,750 Psi (1965)

This paper covers the design and the operational and performance characteristics of a precision pressure generation system utilizing a controlled-clearance type of piston gage. Programmed computer outputs for generating precise pressures automatically in increments smaller than 1 psi over the entire system range have been used to eliminate computational requirements and to generate a large number of pressures rapidly. Piston fall rates have been controlled using constantly varying jacket pressures to maintain sensitivity and flotation requirements, and to keep wear down to a minimum. Experience regarding constancy of pressure output over a period of three years is covered. The amount of actual time in use for the system is well over a thousand hr.
Data management and query---Multiple range query optimization with distributed cache indexing (2006)

MQO is a distributed multiple query processing middleware that can use resources available on the Grid to optimize query processing for data analysis and visualization applications. It does so by introducing one or more proxies that act as front-ends to a collection of backend servers. The basic idea behind this architecture is active semantic caching, whereby queries can leverage available cached results in the proxy either directly or through transformations. While this approach has been shown to speed up query evaluation under multi-client workloads, the caching infrastructure in the backend servers is not used well for query processing. Because this collective caching infrastructure scales with the number of servers, it is an important asset. In this paper, we describe a distributed multidimensional indexing scheme that enables the proxy to directly consider the cache contents available at the backend servers for query planning and scheduling. This approach is shown to produce better query plans and faster query response times as we experimentally demonstrate.
Matched filter based synchronizer design for rapid synchronization of packet data transmissions in DS-CDMA personal communications systems (2002)

This paper considers two types of digital matched filter-based synchronizers. One is applied with biphase spreading, and the other with quadri-phase spreading. The synchronizers are primarily designed for application on reverse links of the IS-95 type systems, but with minor modifications they can also be used in other DS-CDMA systems. Probabilities of correct acquisition and false alarm for both Gaussian and Rayleigh fading channels are derived. The differential approach is considered to reduce the number of required operations. Numerical results are presented when a specially designed packet synchronization preamble is used, and the mean acquisition time is evaluated.
Redox reactions of the nitrogenase complex from Azotobacter vinelandii (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRedox reactions of the nitrogenase complex from Azotobacter vinelandiiS. Lough, A. Burns, and G. D. WattCite this: Biochemistry 1983, 22, 17, 4062–4066Publication Date (Print):August 16, 1983Publication History Published online1 May 2002Published inissue 16 August 1983https://pubs.acs.org/doi/10.1021/bi00286a011https://doi.org/10.1021/bi00286a011research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidation of Aromatic 1,2-Dimethanols by Activated Dimethyl Sulfoxide (1994)

A series of substituted ortho-phthalaldehydes were prepared under mild conditions in respectable yields by oxidation of the corresponding dimethanols using oxalyl chloride activated dimethyl sulfoxide.
Fast Evaluation of Quadratic Control-Lyapunov Policy (2010)

The evaluation of a control-Lyapunov policy, with quadratic Lyapunov function, requires the solution of a quadratic program (QP) at each time step. For small problems this QP can be solved explicitly; for larger problems an online optimization method can be used. For this reason the control-Lyapunov control policy is considered a computationally intensive control law, as opposed to an “analytical” control law, such as conventional linear state feedback, linear quadratic Gaussian control, or H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> , too complex or slow to be used in high speed control applications. In this note we show that by precomputing certain quantities, the control-Lyapunov policy can be evaluated extremely efficiently. We will show that when the number of inputs is on the order of the square-root of the state dimension, the cost of evaluating a control-Lyapunov policy is on the same order as the cost of evaluating a simple linear state feedback policy, and less (in order) than the cost of updating a Kalman filter state estimate. To give an idea of the speeds involved, for a problem with 100 states and 10 inputs, the control-Lyapunov policy can be evaluated in around 67 μs, on a 2 GHz AMD processor; the same processor requires 40 μs to carry out a Kalman filter update.
Development of Novel Process for the Deposition of Nanostructured Ternary Alloys and Composites for Replacement of Cadmium Coatings (2003)

Abstract : The objective of this investigation was to develop novel processes for depositing ternary Zn-Ni-X (X=Cu or P) alloys for replacement of Cd coatings in sacrificial protection of steel substrates. Introducing small amounts of Cu in the Zn-Ni plating bath results in alloys with reduced amount of Zn in the final deposit. This alloy shows improved corrosion performance that is 4 times higher than that of Cd coatings. Also, the use of autocatalytic method was investigated to deposit amorphous Ni-Zn-P alloys. The electroless Ni-Zn-P alloy shows improved corrosion performance that is 5 times higher than that of Cd coatings and reduces the hydrogen ingress into steel to 94%. A novel electrolytic process was developed to deposit Ni-Zn alloys with high Ni content. Deposition parameters like pH and temperature were optimized based on composition and the surface morphology of the coating. The Zn content in the coating was optimized based on the corrosion resistance of the final deposit. Finally. corrosion studies shows that Ni-Zn coatings obtained using these methods show a 5 times increase in barrier resistance as compared to Cd coatings. Also a mathematical model was developed to study the electroless Ni-Zn-P deposition.