gebhart/patrepeval huggingface dataset:
Abstract 8789: Serial Measurements of C-Reactive Protein in Predicting Clinical Outcomes in Patients with Acute Aortic Intramural Hematoma (2011)

Background: Inflammation is involved in the pathogenesis and progression of acute aortic dissection, and a high circulating C-reactive protein (CRP) level may be a risk factor for adverse events in patients with aortic dissection. However, there is no data regarding time course in CRP levels during acute phase in patients with aortic intramural hematoma (IMH). The aim of this study was to evaluate the prognostic relevance of serial CRP measurements in patients with IMH. Methods: A total of 180 IMH patients (age; 70±11 years, male/female; 105/75) who were admitted to our institution within 48 hours from the onset, were evaluated. CRP data were obtained at admission, 2 days, 1 week, 2 weeks from the onset and maximal values during hospitalization. Patients who underwent surgery within 2 weeks from the onset were excluded. Clinical outcomes were evaluated with a mean follow-up of 5.1±3.9 years. Results: CRP levels were 3.0±4.6, 8.7±5.9, 9.0±5.5, and 5.7±4.5 mg/dL at admission, 2 days, 1 week and 2 weeks, respectively. Maximal value of CRP was 12.4±6.3 mg/dL. There were 23 deaths including 9 cases of aortic rupture, and 23 patients underwent surgical or percutaneous repair during follow-up and 19 patients showed progression to classic aortic dissection or aortic aneurysm without surgery. CRP levels at 2 weeks of patients with aorta-related events were significantly higher than that of patients without the events (8.8±5.2 vs 4.5±3.6; P&lt;0.001). Receiver-operating characteristic curve analysis identified CRP level of 5.0 mg/dL at 2 weeks as a cut off for predicting aorta-related events, with sensitivity, specificity, and positive and negative predictive values of 71%, 66%, 35%, and 86%, respectively. The aorta-related event free survival was significantly higher in patients with lower CRP (≤5.0) at 2 weeks (P&lt;0.001,Figure). Conclusions: Sustained high levels of CRP at 2 weeks from the onset were associated with a progressive disease course in patients with IMH.
New perturbation bounds for the discrete-time Hinf filtering problem (2002)

International audience
Optimization of the Double-Row 16-channel Transmit-only RF Array Coil for Human Brain Imaging at 9.4T. (2023)

At 9.4T, transmit-only RF array coils for human brain imaging provide mediocre transmit efficiency due to a weak loading factor, which implies low power dissipation in the tissues. In this work we aim to optimize using the full-wave simulations a dual row 16-channel transmit-only array to improve the transmit performance. For that purpose, we simulated eight different array designs containing the loops with overlapping and gaps between the rows and two configurations of loopoles. We have shown that the optimized design with the overlapped loops provides improvement ~15% in Tx-efficiency and 16.5% improvement in SAR-efficiency compared to the reference coil.
Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed (2013)

An agonist CD40 monoclonal antibody (CP-870,893), in combination with gemcitabine, is well tolerated in patients with advanced pancreatic adenocarcinoma. The combination results in induction of cytokines, B cell activation, and clinical responses. These findings support testing of immunotherapies in combination with other established and targeted therapies.
Performance conditioning of time delayed bilateral teleoperation system by scaling down compensation value of communication disturbance observer (2010)

Time delay in bilateral control system seriously deteriorates the performance and stability. A time delay compensation method based on the concept of network disturbance (ND) and communication disturbance obsrver (CDOB) has been proposed and the validity has been verified so far. Time delay compensation by CDOB improves the ¿Operationality¿ of master robot but simultaneously deteriorates ¿Reproducibility¿ of environmental impedance. This paper proposes scaling down compensation value(SDCV) of CDOB only in contact motion with an environment to realize both good reproducibility and operationality. Reproducibility is improved in all frequency range by scaling down compensation value from 0 to 1.0. The validity of proposal is verified by experimental results.
A Survey of Malware Detection Techniques (2007)

Abstract 31 Introduction 42 What is Malware? 4 2.1 Who are the Users and Creators of Malware? . . . . . . . . . . . . . . . 6 3 The Malware Detector 64 Malware Detection Techniques 7 4.1 Anomaly-based Detection . . . . . . . . . . . . . . . . . . . . . . . . . . 94.1.1 Dynamic Anomaly-based Detection . . . . . . . . . . . . . . . . 104.1.2 Static Anomaly-based Detection . . . . . . . . . . . . . . . . . . 154.1.3 Hybrid Anomaly-based Detection . . . . . . . . . . . . . . . . . . 164.2 Speciﬁcation-based Detection . . . . . . . . . . . . . . . . . . . . . . . . 184.2.1 Dynamic Speciﬁcation-based Detection . . . . . . . . . . . . . . 184.2.2 Static Speciﬁcation-based Detection . . . . . . . . . . . . . . . . 264.2.3 Hybrid Speciﬁcation-based Detection . . . . . . . . . . . . . . . 284.3 Signature-based detection . . . . . . . . . . . . . . . . . . . . . . . . . . 314.3.1 Dynamic Signature-based Detection . . . . . . . . . . . . . . . . 334.3.2 Static Signature-based Detection . . . . . . . . . . . . . . . . . . 344.3.3 Hybrid Signature-based Detection . . . . . . . . . . . . . . . . . 38
Functionally Graded Structures through Building Manufacturing (2013)

The construction industry is facing an increasing pressure to optimize its performance reducing costs and minimizing its impact on the environment. The built environment is a very demanding human and dynamic environment facing rising challenges to develop more innovative and efficient solutions. New technologies, growing client expectations and a shift in design thinking are motivating radical improvements in the construction sector towards more integrated systems through computational fabrication processes. A RapidConstruction System was developed based on extrusion-based technologies to enable the construction of eco-efficient buildings with complex forms and geometries. The optimization of this new system will enable to integrate the concept of material space, material composition information of building heterogeneous components with geometry information, assigning different spatial features according to requirements. This new 3D digital processing system was used to fabricate functional graded structural components with different material compositions, so its functional requirements can vary with location. The development of this multi-material deposition system is ongoing to enable the fabrication of more efficient structures regarding thermal, acoustic and structural conditions.
An Analysis: Hyperglycemic Intensive Care Patients Need Continuous Glucose Monitoring—Easier Said than Done (2008)

Experts and agencies increasingly advocate tight glycemic control (TGC) using intensive intravenous insulin therapy in critically ill patients. Questions remain about the "best" glucose goal, the universal benefit of TGC in the heterogeneous adult intensive care unit (ICU) population, and concerns about the underrecognized incidence of hypoglycemia and its neuropsychological sequelae. TGC is time-consuming for ICU staff, and pathophysiologic, technical, and personnel factors impact the accuracy of point-of-care glucose monitoring. TGC in the ICU requires safe, accurate, robust, rapid, and continuous glucose measurements (CGM) that lack interference from drugs or other substances. Establishment of reliable CGM may provide the foundation for a closed loop, microprocessed system resulting in an artificial islet cell. This commentary focuses on reports from two respected groups on the potential use of CGM devices in the critically ill. It emphasizes the challenges of applying this technology in the ICU and looks to future refinements to address them.
Potential Application of the Surface Reference Technique Over Land at Large Incidence Angle (1999)

Airborne meteorological radars typically operate at attenuating wavelengths. Correction for attenuation along the propagation path, therefore, is required to retrieve reflectivity factor for accurate estimation of the rainfall rate. The surface reference technique (SRT) to correct the observed reflectivity for the effects of attenuation has been developed for down-looking radars (Meneghini et al.,1983). The SRT algorithm uses the radar cross section of the ocean surface as a means of estimating the path integrated attenuation. In the SRT an initial value is determined for the radar cross section of a rain-free area in relatively close proximity to the rain cloud. During subsequent observations of precipitation any decrease in the observed surface cross section from the reference value is assumed to be a result of the two-way attenuation along the propagation path (PIA). The PIA for each beam is then used as a limiting condition in an attenuation correction algorithm (Iguchi and Meneghini, 1994).
Structure Effect of Imidazolium-Based Dicationic Ionic Liquids on Claisen Rearrangement (2014)

Abstract A large group of imidazolium-based dicationic ionic liquids (DILs) has been prepared in good yields. Thermal stability of all DILs has been determined. The effects of the reaction time, cation, imidazolium C2–H acidity, and anion on the Claisen rearrangement of allyl phenyl ether have been investigated. Type of anion and the presence of the acidic C2–H bond in the imidazolium moieties have proven to be essential for this reaction. The simple procedure and the possibility of avoiding the use catalysts and volatile organic solvents make this synthetic method environmentally benign and adaptable for large-scale applications.
GENE INTERACTIONS OF ALPHA-ADDUCIN AND LANOSTEROL SYNTHASE IMPACT RENAL IMPAIRMENT IN SALT SENSITIVE HYPERTENSION (2018)

Objective: The genes involved in the development of renal damage and salt sensitive hypertension (SS) are unknown. Renal impairment is considered to be the major determinant of salt sensitive hypertension. Design and method: We explored the roles of alpha-adducin (ADD1) and lanosterol synthase (LSS), genes coding for structural proteins of the cell membrane and Endogenous Ouabain (EO), respectively, on renal Na handling and their genetic interactions in a large cohort of naïve hypertensive patients (NHP) whose salt sensitive phenotype was characterized. Acute saline load (NaCl 308 mEq/2 h e.v.) was performed in 774 NHP (age 44.95 ± 9.61 years), and functional and hormone renal parameters were tested. Results: Under baseline conditions NHP carriers of the LSS AA genotype showed lower GFR (n = 68, 115.7 ± 4.6 ml/min) compared to LSS C carriers (124.6 ± 1.4 ml/min, p = 0.066). After an acute saline test, GFR increased in both groups, while the urinary volume and urinary creatinine were lower in LSS AA. Analysis of gene*gene interactions demonstrated that NHPs carrying both mutated GT ADD1 and homozygous for LSS C variants excreted the sodium load more rapidly than their ADD1*LSS mutated variants. On the other hand, an additive (p = 0.003) effect of ADD1 GT & LSS AA variants on the pressure-natriuresis relationship was observed, with a significant right shift along the x axis. Finally, circulating EO was modified according to the LSS variant: in SS LSS AA, EO rose signicantly during the recovery while in SR LSS AA, EO was suppressed as were aldosterone and PRA. Conclusions: The results demonstrate: 1. NHPs carrying the LSS AA genotype have reduced GFR under basal conditions; 2. Salt Sensitive LSS AA are EO non-modulators, since their circulating EO does not decline under circumstances where the RAAS is suppressed; 3. The ADD1*LSS interaction identifies those NHPs with impaired renal Na handling.
Radiation and chemical resistance of synthetic ceramics based on ferritic garnet (2008)

Critical dose of X-ray amorphization of the garnet phase Ca1.5Gd0.908Cm0.092Th0.5ZrFe4O12, which is the base of the synthetic ceramics doped with 241Cm (∼2 wt %), was determined. Amorphization occurs at a dose of 1.6 × 1018 α-decay g−1 or 0.17 dpa (displacements per atom). The chemical resistance of the amorphized ceramics to leaching (MCC-1 test) is comparable to that of the initial ceramics. The rates of Cm leaching from the freshly prepared and amorphized ceramics decrease with time and after storage for two weeks amount to 1.4 × 10−3 and 5.8 × 10−3 g m−2 day−1, respectively. Data on thermal restoration of the crystal structure of the ceramics are also presented.
Aberrarone: A Gorgonian-Derived Diterpene from Pseudopterogorgia elisabethae (2009)

A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum.
Conference chairs' message (2017)

Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
ÇEVRE EĞİTİMİ ÖZ-YETERLİK ALGISI ÜZERİNE BİR ÖLÇEK GELİŞTİRME ÇALIŞMASI (2009)

Bu calismada, “Cevre Egitimi Oz-yeterlik Algisi Olcegi” gelistirilmistir. Olcegin guvenirlik katsayisi 0.76 olup toplam varyansin %61.80’ ini aciklamaktadir. Olcek dort alt boyutludur (“Akademik Yetkinlik Algisi”, “Sorumluluk Algisi”, “Ogretici Yetkinlik Algisi...
The plane-wave short-term structure function with finite turbulence scales: an empirical approach (1991)

Abstract The short-term structure function Dst(ρ) with arbitrary outer (L0) and inner (l0) turbulence scales is evaluated by two different methods. In the first method, the short-term structure function is assumed to statistically represent all wavefront distortions other than tilt. The second method comprises a novel technique, in which the short-term structure function is evaluated by replacing the outer turbulence scale L0 in the Von-Karman spectrum by an effective short-term scale which also depends on the aperture diameter D, Lst(L0, D)<L0, thereby minimizing the contribution of large-size turbulence eddies which only give rise to beam tilts. While both methods give very close results when ρ≪D, the empirical approach has some computational advantages and a wider regime of validity.
Parallel changes in large scale software development: an observational case study (2002)

An essential characteristic of large scale software development is parallel development by teams of developers. How this parallel development is structured and supported has a profound effect on both the quality and timeliness of the product. We conduct an observational case study in which me collect and analyze the change and configuration management history of a legacy system to delineate the boundaries of, and to understand the nature of, the problems encountered in parallel development. The results of our studies are: 1) that the degree of parallelism is very high-higher than considered by tool builders; 2) there are multiple levels of parallelism and the data for some important aspects are uniform and consistent for all levels and 3) the tails of the distributions are long, indicating the tail, rather than the mean, must receive serious attention in providing solutions for these problems.
Reduced order model based state feedback control of Doubly Fed Induction Generators (2016)

A state feedback control strategy for Doubly Fed Induction Generator (DFIGs) is investigated. Both the rotor side converter and grid side converter control of DFIG has been designed using the proposed state feedback control technique. A comparison between the traditional PI based vector control (VC) of DFIG with the proposed form of control has also been presented. It has been shown that this methodology helps in easier controller design for DFIG, exhibits competitive performance in terms of low interaction between power and voltage control and provides better system damping. The simulation results for a system connected to a grid through a transmission line have been presented and the capabilities of the proposed controller are discussed.
Encapsulation by hypotonic dialysis in human erythrocytes: a diffusion or endocytosis process (1991)

Human erythrocytes subjected to controlled hypotonic dialysis are capable of encapsulating and retaining drugs. Under selected conditions encapsulation has been reported to occur by an endocytosis process. The mechanism by which encapsulation occurs under conditions which are conducive for endocytosis to occur was studied. An analysis of the percentage of cells with endocytic vacuoles was made for cells dialyzed to optimal and suboptimal osmotic pressures for encapsulation. No differences were found with approximately 20% of cells from all preparations containing vacuoles. Transmission electron micrographs of cells in different stages of carrier cell preparation reveal endocytic vacuoles both with and without hemoglobin. However, based on the percentage of exogenous substance encapsulated, encapsulation appears to occur primarily by diffusion and secondarily by endocytosis.
Taking into Account Manufacturing Faults in PMSM for Diagnosis Purposes (2012)

International audience
The original Bassini operation for inguinal hernia. A. Chinaglia. 200 × 275 mm. Pp. 114. Illustrated. 1988. Padua. Italy: Piccin Nuova Libreria. £22.00 (1989)

The original Bassini operation for inguinal hernia. A. Chinaglia. 200 × 275 mm. Pp. 114. Illustrated. 1988. Padua. Italy: Piccin Nuova Libreria. £22.00 Get access The Original Bassini Operation for Inguinal HerniaA Chinaglia. 200 × 275 mm. Pp. 114. Illustrated. 1988. Padua. Italy: Piccin Nuova Libreria. £22.00. H B Devlin H B Devlin Consultant Surgeon North Tees General Hospital, Stockton-on-Tees, UK Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 76, Issue 9, September 1989, Page 991, https://doi.org/10.1002/bjs.1800760948 Published: 07 December 2005
Unbiased Proteomic Approach Identifies Unique and Coincidental Plasma Biomarkers in Repetitive mTBI and AD Pathogenesis (2018)

The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer's disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Plasma biomarkers potentially provide non-invasive tools for detecting neurological changes in the brain, and can reveal overlaps between long-term consequences of r-mTBI and AD. In this study we address this by generating time-dependent molecular profiles of response to r-mTBI and AD pathogenesis in mouse models using unbiased proteomic analyses. To model AD, we used the well-validated hTau and PSAPP(APP/PS1) mouse models that develop age-related tau and amyloid pathological features, respectively, and our well-established model of r-mTBI in C57BL/6 mice. Plasma were collected at different ages (3, 9, and 15 months-old for hTau and PSAPP mice), encompassing pre-, peri- and post-"onset" of the cognitive and neuropathological phenotypes, or at different timepoints after r-mTBI (24 h, 3, 6, 9, and 12 months post-injury). Liquid chromatography/mass spectrometry (LC-MS) approaches coupled with Tandem Mass Tag labeling technology were applied to develop molecular profiles of protein species that were significantly differentially expressed as a consequence of mTBI or AD. Mixed model ANOVA after Benjamini-Hochberg correction, and a stringent cut-off identified 31 proteins significantly changing in r-mTBI groups over time and, when compared with changes over time in sham mice, 13 of these were unique to the injured mice. The canonical pathways predicted to be modulated by these changes were LXR/RXR activation, production of nitric oxide and reactive oxygen species and complement systems. We identified 18 proteins significantly changing in PSAPP mice and 19 proteins in hTau mice compared to their wild-type littermates with aging. Six proteins were found to be significantly regulated in all three models, i.e., r-mTBI, hTau, and PSAPP mice compared to their controls. The top canonical pathways coincidently changing in all three models were LXR/RXR activation, and production of nitric oxide and reactive oxygen species. This work suggests potential biomarkers for TBI and AD pathogenesis and for the overlap between these two, and warrant targeted investigation in human populations. Data are available via ProteomeXchange with identifier PXD010664.
MIDDLE MIOCENE WAVE INFLUENCED TIDAL DOMINATED LAMBIR FORMATION, MIRI, SARAWAK: CASE STUDY IN TUSAN BEACH AND LAMBIR HILL (2019)

The Middle Miocene sedimentary faciess classified as the Lambir Formation at Tusan Beach and Lambir Hill is revealed as tide dominated with exposed minor wave regimes association. Evidence of wave dominated facies is displayed mostly on shoreline deposits, such as planar cross stratified (PcS), swaley cross stratified (ScS), swaley-Hummocky cross stratified (SHcS) and hummocky cross stratified (HcS). The facies analysis reveals four facies associations, namely; foreshore facies association, upper shoreface, middle shoreface and lower shoreface. Whereas, tide dominated regime resulted three major facies association: tidal sand bar (TSB) facies association, tidal sand flat facies association (TSF) and subtidal mud flat (SMF). TSB facies association was developed from tide influenced shoreline that represented by herringbone cross stratified sandstone bed. The occurrence of herringbone cross stratified and other tidally structures within same facies explain that the current activities are in reversal process (flood and ebb). TSF and SMF facies associations, are widely distributed in the central Miri region including part of Lambir Hill and the Nakat River area. Wide exposure of frequent heterolitic beds, suggest that the Lambir Formation was deposited within the tidal flat environment.
Not Junk After All (2003)

Repetitive elements called Alu elements constitute more than 10% of the human genome yet do not appear to code for proteins. In his Perspective,
 Makalowski
 discusses new work (
 Lev-Maor
 et al.) that sheds light on how Alu elements become inserted into the coding regions of genes resulting in the formation of new proteins and thus contributing to evolution.