gebhart/patrepeval huggingface dataset:
An NN-based dynamic time-slice scheme for bandwidth allocation in ATM networks (2002)

In this paper, we propose a neural network (NN) approach for adaptive bandwidth allocation in ATM networks. This method is essentially based on the dynamic time-slice (DTS) scheme proposed by K. Sriram (1993) which guarantees a required bandwidth for each traffic class and/or virtual circuit (VC). Instead of using analytical static traffic tables to allocate bandwidth, we use NNs to adaptively estimate the effective bandwidths of different call types to reflect the time-varying nature of traffic conditions. Simulation results show that the neural estimation is more accurate and hence leads to higher resource utilization. The NN approach also provides faster response in reallocation of bandwidth to meet the stringent delay requirements.
Graphene enriched with pyrrolic coordination of the doped nitrogen as an efficient metal-free electrocatalyst for oxygen reduction (2012)

We report an efficient template-free synthetic route for the preparation of mesoporous nitrogen-doped graphene (NGE) containing a high weight percentage of pyrrolic nitrogen, good specific surface area and comparable electrochemical oxygen reduction activity as that of the state-of-the-art 40 wt% Pt/C catalyst. The desired coordination of nitrogen in the carbon framework of graphene has been conceived by a mutually assisted redox reaction between graphene oxide (GO) and pyrrole, followed by thermal treatment at elevated temperatures. NGE exhibits a high surface area of 528 m2 g−1 and a pore diameter of ∼3 to 7 nm. The heat treatment temperature plays a pivotal role in establishing the desired pyrrolic coordination of nitrogen in graphene for the electrochemical oxygen reduction reaction. The NGE sample obtained after heat treatment at 1000 °C (NGE-1000) has 53% pyrrolic nitrogen content compared to the similar samples prepared by treating at low temperatures. Most importantly, NGE-1000 has displayed a significantly low overpotential for oxygen reduction with the onset potential very closely matching that of the commercial 40 wt% Pt/C. It is noteworthy that the reaction involves the desired 4 electron transfer as observed in the case of the Pt based electrocatalysts, leading to a significantly high kinetic current density of 6 mA cm−2 at −0.2 V. Moreover, the fuel tolerance and durability under the electrochemical environment of the NGE catalyst is found to be superior to the Pt/C catalyst.
The Cellular Form of Human Fibronectin as an Adhesion Target for the S Fimbriae of Meningitis-Associated Escherichia coli (1999)

The adhesion of the S fimbriae of meningitis-associated Escherichia coli O18ac:K1:H7 to the cellular and the plasma forms of human fibronectin was studied. E. coli HB101(pAZZ50) expressing the complete S-fimbria II gene cluster of E. coli O18 adhered to cellular fibronectin (cFn) on glass but not to plasma fibronectin (pFn). Adhesion to cFn was specifically inhibited by neuraminidase treatment of cFn as well as by incubation of the bacteria with sialyl-alpha2-3-lactose, a receptor analog of the S fimbriae. No significant adhesion to cFn or pFn was detected with E. coli HB101(pAZZ50-67) expressing S fimbriae lacking the SfaS lectin subunit. Strain HB101(pAZZ50) also adhered to a human fibroblast cell culture known to be rich in cFn, and the adhesion was specifically inhibited in the presence of polyclonal antibodies to cFn. The results show that the SfaS lectin of the S fimbriae mediates the adherence of meningitis-associated E. coli to sialyl oligosaccharide chains of cFn.
FASTER-CE: Fast, Sparse, Transparent, and Robust Counterfactual Explanations (2022)

Counterfactual explanations have substantially increased in popularity in the past few years as a useful human-centric way of understanding individual black-box model predictions. While several properties desired of high-quality counterfactuals have been identified in the literature, three crucial concerns: the speed of explanation generation, robustness/sensitivity and succinctness of explanations (sparsity) have been relatively unexplored. In this paper, we present FASTER-CE: a novel set of algorithms to generate fast, sparse, and robust counterfactual explanations. The key idea is to efficiently find promising search directions for counterfactuals in a latent space that is specified via an autoencoder. These directions are determined based on gradients with respect to each of the original input features as well as of the target, as estimated in the latent space. The ability to quickly examine combinations of the most promising gradient directions as well as to incorporate additional user-defined constraints allows us to generate multiple counterfactual explanations that are sparse, realistic, and robust to input manipulations. Through experiments on three datasets of varied complexities, we show that FASTER-CE is not only much faster than other state of the art methods for generating multiple explanations but also is significantly superior when considering a larger set of desirable (and often conflicting) properties. Specifically we present results across multiple performance metrics: sparsity, proximity, validity, speed of generation, and the robustness of explanations, to highlight the capabilities of the FASTER-CE family.
Effects of Co-Base Alloy Powder Addition on Wear-Resistance and Anti-Seizure Property of Cu-Sn-Pb Alloys. (1997)

An attempt was made to develop an automotive plane bearing material having improved wear-resistant and anti-seizure properties to meet severe requirements for the greater load and boundary lubrication. Wear-resistant and hard cobalt-base alloy powder up to 7wt% was blended in the soft Cu-3%Sn-23%Pb matrix alloy powder. The mixture was spread over the backing steel sheet, primarily sintered in the decomposed propane gas, rolled for densifying and secondarily sintered. The cobalt-base hard particles containing molybdenum and chromium are evenly dispersed in the soft matrix. These dispersoids having heterogeneous microstructure lead to hardening of the sintered composite alloy and to improvements in its wear-resistance and anti-seizure property. The wear of shaft is also lightened.
Live Wire – A Low-Complexity Body Channel Communication System for Landmark Identification (2020)

This paper presents a robust simplex Body Channel Communication (BCC) system aimed at providing an interactive infrastructure solution for visually impaired people. Compared to existing BCC solutions, it provides high versatility, wearability and installability in an environment in a low complexity hardware-software solution. It operates with a ground referred–transmitter (TX) and it is based on an asynchronous threshold receiver (RX) architecture. Synchronization, demodulation and packetizing and threshold control are completely software defined and implemented using MicroPython. The RX includes Bluetooth® (BT) radio connectivity and a cell-phone application provides push text-to-speech notifications to a smartphone. The hardware achieves a Packet Error Rate (PER) of <inline-formula><tex-math notation="LaTeX">$\sim$</tex-math></inline-formula> 0.1 at 550 kHz pulse center frequency, Synchronized-On Off Keying (S-OOK) modulation and 1 kbps data rate, for an average current consumption of 44 mA.
Autoantibodies in SLE: prediction and the p value matrix (2019)

Autoantibodies (AA) and antinuclear antibodies (ANA) serve as key diagnostic and classification criteria for systemic lupus erythematosus (SLE). More than 200 different AA have been reported in SLE, although only a handful (<20) are considered "mainstream" because they are widely and routinely used in diagnostic, research and clinical medicine. Although the vast majority of AA have been relegated to the diminished status of "orphan" AA, some serve as predictors of SLE because they first appear in very early or subclinical SLE. Some AA are pathogenic, whereas others are thought to protect against or ameliorate disease progression and, hence, taken together can be used as predictive biomarkers of prognosis. Although studies have shown that specific AA are detected in the preclinical phase of SLE and are biomarkers of increased risk of developing the disease, AA are currently not widely used to predict very early SLE in individuals who have low pretest probability of disease. With the advent of multianalyte arrays with analytic algorithms, emerging evidence indicates that when certain combinations of biomarkers, such as the interferon signature and stem cell factor accompany AA and ANA, the predictive power for SLE is markedly increased.
Environmental Influences on Panicle Differentiation and Spikelet Number of Pennisetum americanum (1986)

Journal Article Environmental Influences on Panicle Differentiation and Spikelet Number of Pennisetum americanum Get access PETER D. COALDRAKE, PETER D. COALDRAKE Department of Agronomy and Horticultural Science, University of SydneyN.S.W 2006, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar CRAIG J. PEARSON CRAIG J. PEARSON Department of Agronomy and Horticultural Science, University of SydneyN.S.W 2006, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Experimental Botany, Volume 37, Issue 6, June 1986, Pages 865–875, https://doi.org/10.1093/jxb/37.6.865 Published: 01 June 1986 Article history Received: 05 August 1985 Published: 01 June 1986
Binding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication (1989)

The binding of a herpes simplex virus type 1 (HSV-1) encoded polypeptide to a viral origin of DNA replication has been studied by using a gel retardation assay. Incubation of nuclear extract from HSV-1 infected cells with a labelled origin-containing fragment resulted in the formation of a specific retarded complex, the migration of which was further reduced in the presence of an antibody reactive with the UL9 gene product. Introduction of an additional copy of the UL9 gene, under the control of an immediate early (IE) promoter, conferred the ability to express origin binding activity at the non-permissive temperature upon an HSV-1 ts mutant blocked at the IE stage of infection. Endogenous or exogenous proteolytic activity revealed the presence of a relatively protease-resistant domain which retained sequence-specific DNA binding activity. The C-terminal 317 amino acids of the UL9 gene expressed as a fusion protein in Escherichia coli also bound to the origin. Our results demonstrate that the UL9 gene product binds to a viral origin and that sequence specific recognition and binding are specified by the C-terminal 37% of the polypeptide.
C‐terminal region of Bfl‐1 induces cell death that accompanies caspase activation when fused with GFP (2005)

Previously, we reported that anti-apoptotic Bfl-1 is converted to a pro-apoptotic protein following fusion at its N-terminus with green fluorescent protein (GFP) (GFP-Bfl-1). In this study, we performed a Bfl-1 deletion study in order to elucidate the underlying mechanism of GFP-Bfl-1-induced cell death. We found that the Bcl-2 homology (BH) domains in Bfl-1 are dispensable with respect to cell death and that GFP fusion with the 29 amino acids of the C-terminal region of Bfl-1 (GFP-BC) is sufficient to induce cell death. Moreover, when BC was fused with other tagging partners like GST or MBP, little cell death was observed, implying that the GFP region is as important as the BC region for GFP-BC-induced cell death. Further deletion analysis defined a region of GFP as a determinant of GFP-BC-induced cell death. Confocal microscopic analysis showed that GFP-chimeras containing the BC region of Bfl-1 are located mainly in mitochondria. The GFP-BC-induced cell death accompanied cellular caspase activation, and treatment with the pan-caspase inhibitor, Boc-D-FMK, partially inhibited GFP-BC-induced cell death. However, the over-expression of anti-apoptotic molecules, such as Bcl-x(L) and CrmA, did not block GFP-BC-induced cell death. In summary, GFP-BC induces cell death with caspase activation through mitochondria dependent process.
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation (2020)

ADP-ribosylation factor (Arf) family consisting of six family members, Arf1-Arf6, belongs to Ras superfamily and orchestrates vesicle trafficking under the control of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins. It is well established that brefeldin A, a potent inhibitor of ArfGEFs, blocks cytokine secretion from activated T cells, suggesting that the Arf pathway plays important roles in T cell functions. In this study, because Arf1 and Arf6 are the best-characterized members among Arf family, we established T lineage-specific Arf1-deficient, Arf6-deficient, and Arf1/6 double-deficient mice to understand physiological roles of the Arf pathway in the immune system. Contrary to our expectation, Arf deficiency had little or no impact on cytokine secretion from the activated T cells. In contrast, the lack of both Arf1 and Arf6, but neither Arf1 nor Arf6 deficiency alone, rendered naive T cells susceptible to apoptosis upon TCR stimulation because of imbalanced expression of Bcl-2 family members. We further demonstrate that Arf1/6 deficiency in T cells alleviates autoimmune diseases like colitis and experimental autoimmune encephalomyelitis, whereas Ab response under Th2-polarizing conditions is seemingly normal. Our findings reveal an unexpected role for the Arf pathway in the survival of T cells during TCR-induced activation and its potential as a therapeutic target in the autoimmune diseases.
Modeling electrical double-layer effects for microfluidic impedance spectroscopy from 100 kHz to 110 GHz (2017)

Broadband microfluidic-based impedance spectroscopy can be used to characterize complex fluids, with applications in medical diagnostics and in chemical and pharmacological manufacturing. Many relevant fluids are ionic; during impedance measurements ions migrate to the electrodes, forming an electrical double-layer. Effects from the electrical double-layer dominate over, and reduce sensitivity to, the intrinsic impedance of the fluid below a characteristic frequency. Here we use calibrated measurements of saline solution in microfluidic coplanar waveguide devices at frequencies between 100 kHz and 110 GHz to directly measure the double-layer admittance for solutions of varying ionic conductivity. We successfully model the double-layer admittance using a combination of a Cole-Cole response with a constant phase element contribution. Our analysis yields a double-layer relaxation time that decreases linearly with solution conductivity, and allows for double-layer effects to be separated from the intrinsic fluid response and quantified for a wide range of conducting fluids.
Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells (1994)

In the present study, we investigated the effect of Listeria monocytogenes infection on the cellular level of the transcription factors NF-kappa B, AP-1, and NF-IL6 in the macrophage-like cell line P388D1 by using electrophoretic mobility shift assays. Infection with L. monocytogenes enhanced the formation of two NF-kappa B-like DNA-protein complexes, C1 and C2, whereas the concentration of AP-1 and NF-IL6 complexes remained unaffected. In supershift assays using NF-kappa B-specific antibodies, complex C2 was identified to be a p50 homodimer (KBF1) and complex C1 was identified as a p50/p65 heterodimer. Both complexes were formed within 10 min after addition of the bacteria. Since the synthesis of tumor necrosis factor alpha and interleukin-1 occurs at later times, these cytokines cannot be the mediators of enhanced NF-kappa B formation. Infection experiments with different nonhemolytic mutants of L. monocytogenes and the use of the phagocytosis inhibitor cytochalasin B suggest that events prior to invasion and escape of the bacteria from the phagosome into the cytoplasm enhance the nuclear transport of p50/p65 NF-kappa B components.
Securing electronic medical records using attribute-based encryption on mobile devices (2011)

We provide a design and implementation of self-protecting electronic medical records (EMRs) using attribute-based encryption on mobile devices. Our system allows healthcare organizations to export EMRs to locations outside of their trust boundary. In contrast to previous approaches, our solution is designed to maintain EMR availability even when providers are offline, i.e., where network connectivity is not available. To balance the needs of emergency care and patient privacy, our system is designed to provide fine-grained encryption and is able to protect individual items within an EMR, where each encrypted item may have its own access control policy. We implemented a prototype system using a new key- and ciphertext-policy attribute-based encryption library that we developed. Our implementation, which includes an iPhone app for storing and managing EMRs offline, allows for flexible and automated policy generation. An evaluation of our design shows that our ABE library performs well, has acceptable storage requirements, and is practical and usable on modern smartphones.
Strategies towards the synthesis of anti-tuberculosis drugs (2019)

Antituberculosis drugs have captured the attention of the scientific community due to the emergence of drug resistance. Hence, the development of new analogs and new drugs which can treat drug-resistant tuberculosis is required. In this report, we reviewed the strategies towards the synthesis of antituberculosis drugs. These strategies include semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis. As stereochemistry is an important hallmark of many drugs, the strategies based on asymmetric synthesis are described in detail. The emphasis on semisynthetic approaches is given for aminoglycoside antibiotics.
Response of Influenza Virus-Infected Mice to Selected Doses of Ribavirin Administered Intraperitoneally or by Aerosol (1977)

The effects of graded doses of ribavirin administered either by aerosol or intraperitoneally were compared in influenza virus-infected mice. The median effective dose values (based upon percent survival) were 3.3 and 15.8 mg/kg per day for the aerosol and intraperitoneal routes, respectively. Lung lesion scores and titer of virus were lower after aerosol than intraperitoneal therapy.
THE REGULATION OF FIRST NATIONS SEXUALITY (1998)

I Resume This paper examines Canada's Indian Act and documents official colonial efforts toward making heterosexuality compulsory in First Nations commu­ nities. The first part of the paper establishes critically the broad range of gender and erotic diversity in First Nations communities prior to European contact. The second part explores racist, patriarchal and heterosexist knowledges and how they worked to regulate those preferring same-sex intimacies. The paper endorses a move away from treating race, gender and sexuality as separate or mutually exclusive categories of experience and analysis toward recognizing these configurations as a system of relations. It proposes de-marginalizing the intersection of race, gender and sexuality in current theories of state formation and First Nations research. Cet article examine la loi sur les indiens du Canada et retrace les efforts coloniaux officiels deployes pour rendre I'heterosexualite obligatoire dans les communautes de Premieres Nations. La premiere partie de I'article etablit de fayon critique la grande diversite des pratiques erotiques et des comportements lies a la masculinite et a la feminite au sein des commu­ nautes autochtones avant Ie contact avec les Europeens. La seconde partie se penche sur les attitudes racistes, patriarcales et heterosexistes et la maniere dont elles se sont appliquees pour controler les individus preferant les rapports homosexuels. L'article rejette Ie traitement de la race, des categories masculine et feminine et de la sexualite comme categories d'experience et d'analyse separees ou encore mutuellement exclusives; iI souscrit a la reconnaissance de ces configurations comme systeme de rapports unifies. \I propose d'ouvrir les frontieres rattachees a la race, a I'orientation sexuelle ainsi qu'a I'acceptation des genres masculin et feminin, et ce tant dans les theories contemporaines de la formation de I'etat que dans les recherches en etudes autochtones.
In the absence of obstructive coronary artery disease, patients with class II and III obesity have decreased myocardial perfusion reserve (2014)

Background Obesity is associated with cardiovascular morbidity and mortality. This quantitative CMR perfusion study aims to examine the contribution of body mass index (BMI) to decreased myocardial perfusion reserve (MPR). Methods 123 patients with no obstructive epicardial coronary artery disease, defined by coronary computed tomographic angiogram demonstrating < 30% stenosis, underwent regadenoson CMR 1st-pass perfusion imaging, using 0.05 mmol/kg gadolinium (Gd) followed by rest perfusion imaging (also 0.05 mmol/kg Gd) performed 20 minutes later. The subjects were categorized into 4 groups: normal BMI (between 18.5-24.9 kg/m2, overweight (BMI 25-29.9 kg/m2), Class I obese (BMI 30-34.9), and Class II and III obese (BMI≥35). Myocardial blood flow (MBF) in ml/min/g and myocardial perfusion reserve (MPR) were quantified using a fully quantitative model constrained deconvolution.
An S- and V-Band Dual-Polarized Antenna Based on Dual-Degenerate-Mode Feeder for Large Frequency Ratio Shared-Aperture Wireless Applications (2020)

An S-/V-band dual-polarized antenna is proposed for large frequency ratio shared-aperture wireless applications, which includes a 2.4 GHz patch and a structural-reused 60 GHz substrate integrated waveguide (SIW) parallel-plate orthogonal long-slot array. A dual-degenerate-mode feeder including a circular waveguide and a coaxial cavity is designed to excite the developed S-/V-band shared-aperture dual-polarized antenna. Two degenerate dominant modes of the circular waveguide and a 180° hybrid junction with five ports are used to realize the dual-polarized differential feeding at V-band. By the use of this differential feeding method, the beam direction of the V-band long-slot array antenna is unchanged with the frequency. Two degenerate high-order modes TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1,1,0.5</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> and TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1,1,0.5</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of the coaxial cavity are used to realize the dual-polarized feeding at S-band. Two SMA connectors for two orthogonal-polarized feeding are placed at their respective electric held minimum points to increase the isolation between input ports. Finally, the dual-band dual-polarized antenna is fabricated and measured.
Quantified Facial Expressiveness for Affective Behavior Analytics (2021)

The quantified measurement of facial expressiveness is crucial to analyze human affective behavior at scale. Unfortunately, methods for expressiveness quantification at the video frame-level are largely unexplored, unlike the study of discrete expression. In this work, we propose an algorithm that quantifies facial expressiveness using a bounded, continuous expressiveness score using multimodal facial features, such as action units (AUs), landmarks, head pose, and gaze. The proposed algorithm more heavily weights AUs with high intensities and large temporal changes. The proposed algorithm can compute the expressiveness in terms of discrete expression, and can be used to perform tasks including facial behavior tracking and subjectivity quantification in context. Our results on benchmark datasets show the proposed algorithm is effective in terms of capturing temporal changes and expressiveness, measuring subjective differences in context, and extracting useful insight.