gebhart/patrepeval huggingface dataset:
ChemInform Abstract: BLDG. VON KOBALT‐KOHLENSTOFF‐SIGMA‐BINDUNGEN (1970)

Abstract Am Beispiel der Komplexe (I) wird die Möglichkeit der Reduktion und anschließenden Alkylierung unter Bildung von Co‐C‐o‐Bindungen in Verbindungen vom "Typ (II) diskutiert.
Post-translational Methylation of High Mobility Group Box 1 (HMGB1) Causes Its Cytoplasmic Localization in Neutrophils (2007)

High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation. HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation. HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu. However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure. Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42. The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus. Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils. This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu.
Deneyim Kalitesi odaklı Akıllı İşbirlikçi Çoklu-erişimli Uç Hesaplama Çerçevesi (2019)

Gunumuzun gelismis radyo erisim teknolojileri, yuksek-tanimli buyuk veri/video trafiginin hizli ve guvenilir iletimini kolaylastirmis olsa da, kullanicilar tarafindan deneyimlenen/algilanan kalite, kaynak (ornegin, bulut sunuculari) ve uc-nokta arasindaki mesafeye dayali yuksek gecikme nedeniyle beklenenden dusuktur. 5G ag erisim teknolojisiyle ivmelenen coklu-erisimli uc hesaplama (MEC) paradigmasinin, bu sorunu MEC sunucularini uc-noktalarin yogunlastigi ag kenarlarinda dagitarak, ve hesaplama, icerik dagitimi, depolama ve sanallastirma islemlerinin onemli bir kismini bu uclar uzerinden gerceklestirerek cozmesi beklenmektedir. Yalniz, MEC sunucularinin kendi aralarinda veya kaynaklar ile uc-noktalar arasinda iletisim kurmasini saglamak icin de yeni ve karmasik protokollere ihtiyac duyulmaktadir. Calisma kapsaminda, haberlesmenin sadece yardimci bir bilgi alisverisi saglayacagi varsayimindan farkli olarak, arac aglarda servis ve deneyim kalitesini ve yolcu konforunu artirmayi amaclayan, yeni nesil kablosuz ve hucresel ag erisim teknolojileri ile yazilim-tanimli aglarin (SDN), coklu-erisimli uc hesaplama (MEC) ve makine ogrenmesi (ML) tekniklerinin entegrasyonunun saglandigi, yeni ve ozgun bir mimari onerilmektedir. Onerilen calisma ile, sadece 5G/IEEE 802.11ac/p gibi yeni nesil ag erisim teknolojileri ve ozellikleri sistem optimizasyonuna dahil edilmeyecek, ayni zamanda sistem tasarimi isbirlikci ve sistematik bir perspektiften koklu degisikliklere ugratilacaktir. Onerilen cozumun, temel olarak yuksek guvenilirlik ve dusuk gecikme arasindaki ikilemi cozmesi ve sonuc olarak hizli ve guvenilir olan uygun fiyatli arac iletisiminin gerceklestirilmesini ve ticarilestirilmesini hizlandirmasi hedeflenmektedir.
Total variation approach for adaptive nonuniformity correction in focal-plane arrays (2011)

In this Letter we propose an adaptive scene-based nonuniformity correction method for fixed-pattern noise removal in imaging arrays. It is based on the minimization of the total variation of the estimated irradiance, and the resulting function is optimized by an isotropic total variation approach making use of an alternating minimization strategy. The proposed method provides enhanced results when applied to a diverse set of real IR imagery, accurately estimating the nonunifomity parameters of each detector in the focal-plane array at a fast convergence rate, while also forming fewer ghosting artifacts.
Analysis of the Salmonella typhimurium Proteome through Environmental Response toward Infectious Conditions (2006)

Salmonella enterica serovar Typhimurium (also known as Salmonella typhimurium) is a facultative intracellular pathogen that causes approximately 8,000 reported cases of acute gastroenteritis and diarrhea each year in the United States. Although many successful physiological, biochemical, and genetic approaches have been taken to determine the key virulence determinants encoded by this organism, the sheer number of uncharacterized reading frames observed within the S. enterica genome suggests that many more virulence factors remain to be discovered. We used a liquid chromatography-mass spectrometry-based "bottom-up" proteomic approach to generate a more complete picture of the gene products that S. typhimurium synthesizes under typical laboratory conditions as well as in culture media that are known to induce expression of virulence genes. When grown to logarithmic phase in rich medium, S. typhimurium is known to express many genes that are required for invasion of epithelial cells. Conversely stationary phase cultures of S. typhimurium express genes that are needed for both systemic infection and growth within infected macrophages. Lastly bacteria grown in an acidic, magnesium-depleted minimal medium (MgM) designed to mimic the phagocytic vacuole have been shown to up-regulate virulence gene expression. Initial comparisons of protein abundances from bacteria grown under each of these conditions indicated that the majority of proteins do not change significantly. However, we observed subsets of proteins whose expression was largely restricted to one of the three culture conditions. For example, cells grown in MgM had a higher abundance of Mg(2+) transport proteins than found in other growth conditions. A second more virulent S. typhimurium strain (14028) was also cultured under these same growth conditions, and the results were directly compared with those obtained for strain LT2. This comparison offered a unique opportunity to contrast protein populations in these closely related bacteria. Among a number of proteins displaying a higher abundance in strain 14028 were the products of the pdu operon, which encodes enzymes required for propanediol utilization. These pdu operon proteins were validated in culture and during macrophage infection. Our work provides further support for earlier observations that suggest pdu gene expression contributes to S. typhimurium pathogenesis.
Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer (2002)

Single-agent trastuzumab is active and well tolerated as first-line treatment of women with metastatic breast cancer with HER2 3+ overexpression by IHC or gene amplification by FISH.
ALK translocation detection in non‐small cell lung cancer cytological samples obtained by TBNA or EBUS‐TBNA (2015)

In this series, smears were unevaluable as a result of inadequate samples, cell overlapping or lack of fixation performed immediately after FNA.
A unique case of progressive hemifacial microsomia or Parry-Romberg syndrome associated with limb and brain anomalies with normal neurological findings: A review of the literature (2021)

In this report, we describe an unusual case of progressive hemifacial atrophy or Parry-Romberg syndrome in a 10-year-old girl with progressive hemifacial microsomia and limb anomalies who had brain magnetic resonance imaging (MRI) findings of white matter hyper-intensities. Patients typically present with neurological manifestations such as epilepsy, facial pain, and migraines and ophthalmological symptoms in conjunction with white matter lesions. The patient demonstrated normal cognition and psychomotor development despite the presence of white matter lesions in her frontal lobe that is commonly associated with neurological symptoms. This report brings attention to the complicated relationship between facial, limb and brain imaging findings in Parry-Romberg syndrome and differentiates it from hemifacial microsomia syndrome.
Development of a single coil coupled force VCM actuator for high TPI magnetic recording (2001)

A novel high bandwidth actuator assembly (HBX4) is developed for the applications of high TPI recording in hard disk drives. The novel design in voice coil motor (VCM) construction, with flat moving-coil, is as simple as a conventional one. The VCM generates orthogonal force or pure torque. A 3D finite element analysis (FEA) is conducted in the electromagnetic design to optimize some critical electromagnetic parameters and the main dimensions. A 3D FEA is also carried out to predict the dynamic performance. The study shows that the lateral quasirigid body vibration mode (QR mode), which limits the servo bandwidth in a conventional actuator, has been substantially suppressed. Measurement of the characteristics of a prototype is carried out and the result is discussed.
Développement de méthodes d'optimisation électromagnétique automatiques. Applications aux dispositifs microondes (1999)

Les performances croissantes des moyens informatiques et les developpements recents des outils de conception assistes par ordinateur permettent aujourd'hui aux concepteurs de circuits microondes d'envisager la mise au point de methodes d'optimisation electromagnetique automatique. L'objectif majeur des methodes d'optimisation electromagnetique est de minimiser le nombre de calculs electromagnetiques necessaires a la conception du dispositif etudie. Le principe actuel consiste a integrer un simulateur electromagnetique global dans une boucle d'optimisation et de la diriger en appliquant : un algorithme d'optimisation pour les methodes d'optimisation electromagnetique directes, un autre simulateur ou un modele simplifie pour les methodes d'optimisation electromagnetique hybrides. Le travail de these presente dans ce manuscrit s'est porte sur le developpement de deux methodes d'optimisation electromagnetique, appliquees en particulier a la conception de filtres hyperfrequences a resonateurs dielectriques. La premiere methode developpee est une methode hybride, generale, qui combine une analyse electromagnetique globale du dispositif par la methode des elements finis et un modele analytique deduit de son analyse electromagnetique segmentee et approchee par un simulateur de reseaux de neurones. La methode d'optimisation hybride est decrite etape par etape puis validee par la conception de deux filtres a resonateurs dielectriques a modes duaux sans reglage experimental. La seconde methode developpee est une methode directe, specifique aux filtres et aux multiplexeurs hyperfrequences, qui combine une methode de synthese de filtres passe-bande, une analyse electromagnetique globale par la methode des elements finis et une methode d'identification de la matrice de couplage basee sur un logiciel d'approximation rationnelle. La methode d'optimisation directe est decrite etape par etape, puis appliquee a la conception d'un filtre elliptique 4 poles a resonateurs dielectriques a encoches, sans reglage experimental et fonctionnant sur des modes duaux. Enfin, les concepts d'optimisation electromagnetique presentes dans ce manuscrit, permettent donc d'envisager avec le developpement des moyens informatiques, la conception de dispositifs et de modules hyperfrequences de traitement du signal dans leur globalite.
Unsuspected articulation side-strut extension during stenting in a tortuous right coronary artery (1997)

This case report demonstrates the effect of articulation stent-strut extension during attempts to deploy a stent in a tortuous, calcified right coronary artery. The manipulation of the stent-sheath relationship and the effect of a tortuous, calcified artery produced serial dissections resulting in the implantation of three stents to seal the dissection. Caution should be used when employing rigid sheathed stent systems through tortuous vessels.
Alkylpolyglucoside ‐ Technologie und Eigenschaften (1993)

Abstract Obwohl oberflächenaktive Kohlenhydratverbindungen seit langer Zeit bekannt sind, ist ihre großtechnische Herstellung erst seit wenigen Jahren aktuell geworden. Aus der Gruppe der bekannten Kohlenhydrattenside werden sich die langkettigen Alkylpolyglucoside in naher Zukunft als großvolumige Leittenside durchsetzen. Die Entwicklung der Zuckertensidchemie generell, und speziell die der Herstellverfahren für Alkylpolyglucoside, werden skizziert und die entscheidenden Produkt‐ und Verfahrensverbesserungen beschrieben, die eine unter ökonomischen und qualitativen Gesichtspunkten marktgerechte, großtechnische Alkylpolyglucosidherstellung ermöglichen. Eine Zusammenfassung der relevanten anwendungstechnischen Leistungsmerkmale der Alkylpolyglucoside vervollständigt das Bild dieser hautmilden, ökologisch und toxikologisch sehr günstig bewerteten Tensidklasse.
Metabolic dysfunction branches out (2016)

Amino acid metabolism is an important driver of heart failure and can be used for both diagnostic and therapeutic targeting in the failing heart.
H syndrome presenting as juvenile diabetes in algerian man (2023)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Localization of Islet-1–Positive Cells in the Healthy and Infarcted Adult Murine Heart (2012)

Our results identify Islet-1 as a novel marker of the adult sinoatrial node and do not provide evidence for Islet-1(+) cells to serve as cardiac progenitors.
Measurement of Vibrational Circular Dichroism Using a Polarizing Michelson Interferometer (1990)

Fourier transform infrared (FT-IR) vibrational circular dichroism (VCD) has been observed for the first time with the use of a polarizing Michelson interferometer (PMI). VCD spectra have been recorded for (–)- α-pinene between 900 and 1350 cm −1 at 4 cm −1 resolution with excellent signal-to-noise ratio. The FT-VCD spectra are virtually the same as those recorded for (–)- α-pinene under the same conditions with the use of the more conventional double modulation FT-IR approach.
Stable–streamlined and helical cavities following the impact of Leidenfrost spheres (2017)

We report results from an experimental study on the formation of stable–streamlined and helical cavity wakes following the free-surface impact of Leidenfrost spheres. Similar to the observations of Mansoor et al. ( J. Fluid Mech. , vol. 743, 2014, pp. 295–326), we show that acoustic ripples form along the interface of elongated cavities entrained in the presence of wall effects as soon as the primary cavity pinch-off takes place. The crests of these ripples can act as favourable points for closure, producing multiple acoustic pinch-offs, which are found to occur in an acoustic pinch-off cascade. We show that these ripples pacify with time in the absence of physical contact between the sphere and the liquid, leading to extremely smooth cavity wake profiles. More importantly, the downward-facing jet at the apex of the cavity is continually suppressed due to a skin-friction drag effect at the colliding cavity-wall junction, which ultimately produces a stable–streamlined cavity wake. This streamlined configuration is found to experience drag coefficients an order of a magnitude lower than those acting on room-temperature spheres. A striking observation is the formation of helical cavities which occur for impact Reynolds numbers $Re_{0}\gtrsim 1.4\times 10^{5}$ and are characterized by multiple interfacial ridges, stemming from and rotating synchronously about an evident contact line around the sphere equator. The contact line is shown to result from the degeneration of Kelvin–Helmholtz billows into turbulence which are observed forming along the liquid–vapour interface around the bottom hemisphere of the sphere. Using sphere trajectory measurements, we show that this helical cavity wake configuration has 40 %–55 % smaller force coefficients than those obtained in the formation of stable cavity wakes.
Method for Designing Adaptive UI Based on User's Context in the Environment Including Mobile Device and Public Display Device (2012)

The one of the most meaningful change in the recent ubiquitous environment is the omnipresence of public digital display device for providing ubiquitous information. It is the important issue to provide publicity as well as adaptive information to each user in the field of the public digital display device. This research proposes the idea ensuring fast response speed by the selection of user preference function. The preference function is selected by statistics using Zipf distribution in the system comprising mobile device and digital display device based on NFC (Near Field Communication). The idea is proved by CPM-GOMS model and the improvement of user response can be achieved.
Table S2 from Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy Are Identified in Ovarian Tumors by Bivalent Chromatin Domains at Initial Diagnosis (2023)

&lt;p&gt;genes with evidence for poised promoter chromatin states in multiple primary high-grade serous ovarian tumours, but not in normal ovarian surface or fallopian epithelia&lt;/p&gt;
Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during PulmonaryMycobacterium bovisBCG Infection (2007)

Gamma interferon (IFN-gamma) is a key cytokine in host defense against intracellular mycobacterial infection. It has been believed that both CD4 and CD8 T cells are the primary sources of IFN-gamma. However, the relative contributions of CD4 and CD8 T-cell subsets to IFN-gamma production and the relationship between CD4 and CD8 T-cell activation have not been examined. By using a model of pulmonary mycobacterial infection and various immunodetection assays, we found that CD4 T cells mounted a much stronger IFN-gamma response than CD8 T cells at various times after mycobacterial infection, and this pronounced IFN-gamma production by CD4 T cells was attributed to both greater numbers of antigen-specific CD4 T cells and a greater IFN-gamma secretion capacity of these cells. By using major histocompatibility complex class II-deficient or CD4-deficient mice, we found that the lack of CD4 T cells did not negatively affect primary or secondary CD8 T-cell IFN-gamma responses. The CD8 T cells activated in the absence of CD4 T cells were capable of immune protection against secondary mycobacterial challenge. Our results suggest that, whereas both CD4 and CD8 T cells are capable of IFN-gamma production, the former represent a much greater cellular source of IFN-gamma. Moreover, during mycobacterial infection, CD8 T-cell IFN-gamma responses and activation are independent of CD4 T-cell activation.
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors (2015)

Anaplastic Thyroid carcinoma is an extremely aggressive solid tumor that resists most treatments and is almost always fatal. Galectin-3 (Gal-3) is an important marker for thyroid carcinomas and a scaffold of the K-Ras protein. S-trans, transfarnesylthiosalicylic acid (FTS; Salirasib) is a Ras inhibitor that inhibits the active forms of Ras proteins. Modified citrus pectin (MCP) is a water-soluble citrus-fruit-derived polysaccharide fiber that specifically inhibits Gal-3. The aim of this study was to develop a novel drug combination designed to treat aggressive anaplastic thyroid carcinoma. Combined treatment with FTS and MCP inhibited anaplastic thyroid cells proliferation in vitro by inducing cell cycle arrest and increasing apoptosis rate. Immunoblot analysis revealed a significant decrease in Pan-Ras, K-Ras, Ras-GTP, p-ERK, p53, and Gal-3 expression levels and significant increase in p21 expression levels. In nude mice, treatment with FTS and MCP inhibited tumor growth. Levels of Gal-3, K-Ras-GTP, and p-ERK were significantly decreased. To conclude, our results suggest K-Ras and Gal-3 as potential targets in anaplastic thyroid tumors and herald a novel treatment for highly aggressive anaplastic thyroid carcinoma.
Cost-effectiveness of serological tests for human visceral leishmaniasis in the Brazilian scenario (2020)

Human visceral leishmaniasis (VL) is a severe and potentially fatal parasitic disease if not correctly diagnosed and treated. Brazil is one of the three countries most endemic for VL and, like most countries affected by this disease, has a large budget constraint for the incorporation of new health technologies. Although different diagnostic tests for VL are currently available in the country, economic studies evaluating diagnostic kits are scarce. The objective of this study was to conduct a cost-effectiveness analysis of the nine available diagnostic tests for human VL in HIV-infected and uninfected patients in Brazil. The perspective of analysis was the Brazilian public health system, and the outcome of interest was "cases diagnosed correctly". The costs of the tests were estimated using the microcosting technique, and comparisons were performed with decision trees. Sensitivity analyses were explored applying variations in cost and effectiveness values. For VL diagnosis among HIV-uninfected patients, using blood samples for the rapid tests (RDTs), the noncommercial direct agglutination test (DAT-LPC) and IT-LEISH were cost-effective tests compared with the baseline OnSite test, but they presented different incremental cost-effectiveness ratios (ICER) of US$7.04 and US$ 205.40, respectively. Among HIV-infected patients, DAT-LPC was the most cost-effective diagnostic test. Comparisons among the tests with the same methodology, based on the low ICER values, revealed that IT-LEISH was the most cost-effective test among the RDTs and the Ridascreen Leishmania Ab among the ELISA tests. These results confirm that cost-effectiveness analyses can provide useful information to support the incorporation of new health technologies within a known scenario and willingness to pay threshold. It was observed that tests based on the same methodologies presented different cost-effectiveness ratios for the same group of patients and that different tests should be recommended for different patient groups. DAT-LPC was an important cost-effective strategy for all patients, requiring minimum laboratorial infrastructure, and IT-LEISH was the cost-effective test for VL screening in HIV-uninfected patients. IT-LEISH and DAT-LPC have complementary profiles and should both be provided by the Brazilian health system.
Amine extraction of hydroxycarboxylic acids. 1. Extraction of citric acid with 1-octanol/n-heptane solutions of trialkylamine (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmine extraction of hydroxycarboxylic acids. 1. Extraction of citric acid with 1-octanol/n-heptane solutions of trialkylamineVladislav Bizek, Jan Horacek, Roman Rericha, and Michaela KousovaCite this: Ind. Eng. Chem. Res. 1992, 31, 6, 1554–1562Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ie00006a019https://doi.org/10.1021/ie00006a019research-articleACS PublicationsRequest reuse permissionsArticle Views431Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts