gebhart/patrepeval huggingface dataset:
Effect of anti-fibroblast growth factor receptor 1 antibodies on phosphorus metabolism in laying hens and their progeny chicks (2019)

Targeting fibroblast growth factor 23 (FGF-23) signaling pathway is of interest in controlling body phosphate metabolism. This study investigated the effect of anti-fibroblast growth factor receptor 1 (FGFR1, major FGF-23 receptor in the kidney) antibodies on phosphate metabolism. White Leghorn laying hens (65-wk-old) were vaccinated with either a FGFR1 peptide vaccine (five 8-amino-acid peptides were selected, CrZ-1:LPEDPRWE, CrZ-2:LDKDKPNR, CrZ-3:RRPPGMEY, CrZ-4:GSPYPGVP, and CrZ-5:RMDKPSNC) or adjuvant control. At peak antibody titer, hens were artificially inseminated. Chicks from control-vaccinated hens were fed either a non-phytate phosphorus (nPP) sufficient (nPP = 0.45%, positive control) or deficient (nPP = 0.20%, negative control) diet, while chicks from each of the FGFR1 peptide vaccinated hens were fed with the above nPP-deficient diet, for 14 D. When compared to control hens, plasma phosphate in CrZ-1, CrZ-2, CrZ-3, CrZ-4, and CrZ-5 vaccinated hens were decreased by 33, 30, 24, 20, and 26%, respectively (P < 0.05); egg weight in CrZ-2 and CrZ-5 vaccinated hens were increased by 6 and 7%, respectively (P < 0.05); egg production in CrZ-3, CrZ-4, and CrZ-5 vaccinated hens tended to decrease (P = 0.085; decreased by 14, 15, and 13%, respectively). When compared to positive control, chicks from all other groups had decreased body weight gain (BWG) and feed intake (FI) during 1 to 14 D, and had decreased plasma phosphate, tibiotarsus ash, and 24-h phosphorus excretion on day 14. When compared to negative control, BWG of CrZ-1, CrZ-2, CrZ-3, and CrZ-4 antibody chicks were decreased by 23, 28, 26, and 20%, respectively (P < 0.05); FI of CrZ-1, CrZ-2, and CrZ-3 antibody chicks were decreased by 15, 15, and 18%, respectively (P < 0.05); plasma phosphate of CrZ-5 antibody chicks were decreased by 26% (P < 0.05); plasma FGF-23 levels of CrZ-4 antibody chicks were increased by 18% (P < 0.05); tibiotarsus ash content of CrZ-2, CrZ-3, and CrZ-4 antibody chicks were decreased by 20, 20, and 21%, respectively (P < 0.05). In conclusion, anti-FGFR1 peptide antibodies decreased egg production of hens and growth performance of their progeny chicks probably by activating FGF-23 signaling and stimulating FGF-23 production.
Succeed or Sink: Business sustainability under globalisation (2011)

Aimed at business strategists, policy makers, researchers and adult learners, this book has an Asian perspective on business sustainability and is about understanding how recent developments and future actions in one part of the world will have a global impact. The book magnifies the concept of so-called ?globalisation? and examines the topic of business sustainability from a broad and integrated approach to business: encapsulating people, prosperity and the planet. Furthermore, it acknowledges the contributions, challenges and potential of not only the big corporate houses, but also the smaller ones, in this situation. Chapters discuss the benefits organisations can attain with better governance, and social and environmental practices are also analysed.
	 

	
		Broad and integrated approach to business encapsulating people, prosperity and sustainability
	
		Details recent developments and future actions in the areas of business sustainability and applicable more globally
	
		Written by highly knowledgeable and well-respected academician and practitioners in the field; a perfect blend of the best of both worlds
Load forecast based on least square SVR and HHT (2017)

Load forecast provides a decision-making basis for scheduling system of power system, synchronous control, operate plan and development program. To achieve high-accuracy of load forecast, many scholars are trying many methods. But the non-stationary, volatile and nonlinear properties of load data makes it much harder for precise load forecast. In this paper a load forecast method is proposed, which is based on least squares support vector regression (LSSVR), an evolutive version of standard support vector regression, and Hilbert-Huang Transform (HHT). This method firstly decomposed the load data to several sub-level data with clear tendency by HHT. Then these sub-level data are forecasted with LSSVR respectively. At last these results were recomposed as the forecast output of the original load data. The appropriate emulation of above forecast model were checked based on some sample data.
Antihypertensive Effects of KW-3902, an Adenosine A1-Receptor Antagonist, in Dahl Salt-Sensitive Rats (1995)

We determined the effects of KW-3902 (8-(noradamantan-3-yl)-1,3- dipropylxanthine), a novel adenosine A1-receptor antagonist, on the development of hypertension in Dahl salt-sensitive (Dahl-S) rats. KW-3902 (0.00017% w/w-0.017% w/w), fed with the diet, prevented the development of hypertension at 2-6 weeks in response to the high (8% w/w) NaCl diet. KW-3902 increased urine volume and sodium excretion and attenuated cardiac hypertrophy. In another series of the experiments employing the clearance method, KW-3902 (0.1 mg/kg, i.v.) increased urine volume, sodium excretion and lithium clearance in anesthetized Dahl-S rats. These results suggest that the antihypertensive effect of KW-3902 in Dahl-S rats is mediated via its natriuretic effect, the site of action being, at least partly, the proximal tubule. The adenosine A1-receptor antagonist may be effective for the treatment of salt-sensitive hypertension.
High temperature sensing using higher-order-mode rejected sapphire fiber gratings (2007)

In this paper, we report the fabrication of higher-order-mode rejected fiber Bragg gratings (FBGs) in sapphire crystal fiber using infrared (IR) femtosecond laser illumination. The grating is tested in high temperature furnace up to 1600 degree Celsius. As sapphire fiber is only available as highly multimode fiber, a scheme to filter out higher order modes in favor for the fundamental mode is theoretically evaluated and experimentally demonstrated. The approach is to use an ultra thin sapphire crystal fiber (60 micron in diameter) to decrease the number of modes. The small diameter fiber also enables bending the fiber to certain radius which is carefully chosen to provide low loss for the fundamental mode LP01 and high loss for the other high-order modes. After bending, less-than-2-nm resonant peak bandwidth is achieved. The grating spectrum is improved, and higher resolution sensing measurement can be achieved. This mode filtering method is very easy to implement. Furthermore, the sapphire fiber is sealed with hi-purity alumina ceramic cement inside a flexible high temperature titanium tube, and the highly flexible titanium tube offers a robust packaging to sapphire fiber. Our high temperature sapphire grating sensor is very promising in extremely high temperature sensing application.
Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat† (2018)

Porphyromonas gingivalis (Pg) is an important periodontal pathogen that is also implicated in pregnancy complications involving defective deep placentation (DDP). We hypothesized that Pg invasion of the placental bed promotes DDP. Pregnant rats were intravenously inoculated with sterile vehicle, Pg strain W83, or A7436 at gestation day (GD) 14 (acute cohort). Nonpregnant rats received repeated oral inoculations for 3 months before breeding (chronic cohort). Tissues and/or sera were collected at GD18 for analysis. Pg infection status was determined by seroconversion (chronic cohort) and by presence of Pg antigen in utero-placental tissues processed for histology and morphometric assessment of spiral artery remodeling. Mesometrial tissues from seropositive dams were analyzed for expression of interleukin 1β, 6, and 10, TNF, TGF-β, follistatin-related protein 3, and inhibin beta A chain since these genes regulate extravillous trophoblast invasion. The in situ distribution of W83 and A7436 antigen in utero-placental tissues was similar in both cohorts. In the acute cohort, mesometrial stromal necrosis was more common with W83, but arteritis was more common with A7436 infection (P < 0.05). Increased vascular necrosis was seen in mesometrium of chronically infected groups (P < 0.05). Only A7436-infected animals had increased fetal deaths, reduced spiral artery remodeling, reduced inhibin beta A expression, and an increased proportion of FSLT3 positive extravillous trophoblasts within spiral arteries. While infection with both Pg strains produced varying pathology of the deep placental bed, only infection with strain A7436 resulted in impaired spiral artery remodeling.
Insulinotropin PACAP Potentiates Insulin Action: Stimulation of Glucose Uptake in 3T3‐LI Adipocytes (2000)

PAC1 receptor was expressed in the rat fat tissue and 3T3-L1 adipocytes. PACAP-38 (10 nM) significantly enhanced insulin induced 2-deoxyglucose uptake by 3T3-L1 adipocytes. GLP-1 has a similar effect. PACAP-38 further increased insulin stimulated phosphatidylinositol (PI) 3-kinase activity, but has not effect on tyrosine phosphorylation of insulin receptor beta-subunit or IRS-1. These results reveal that PACAP-38 enhances insulin induced glucose uptake, an effect probably mediated by PI 3-kinase. In conclusion, PACAP potentiates not only insulin secretion but also insulin action in adipocytes, thereby exhibiting antidiabetic actions at two important steps of glucose metabolism (Fig. 2).
SLIMM: Slice localization integrated MRI monitoring (2020)

Functional MRI (fMRI) is extremely challenging to perform in subjects who move because subject motion disrupts blood oxygenation level dependent (BOLD) signal measurement. It has become common to use retrospective framewise motion detection and censoring in fMRI studies to eliminate artifacts arising from motion. Data censoring results in significant loss of data and statistical power unless the data acquisition is extended to acquire more data not corrupted by motion. Acquiring more data than is necessary leads to longer than necessary scan duration, which is more expensive and may lead to additional subject non-compliance. Therefore, it is well established that real-time prospective motion monitoring is crucial to ensure data quality and reduce imaging costs. In addition, real-time monitoring of motion allows for feedback to the operator and the subject during the acquisition, to enable intervention to reduce the subject motion. The most widely used form of motion monitoring for fMRI is based on volume-to-volume registration (VVR), which quantifies motion as the misalignment between subsequent volumes. However, motion is not constrained to occur only at the boundaries of volume acquisition, but instead may occur at any time. Consequently, each slice of an fMRI acquisition may be displaced by motion, and assessment of whole volume to volume motion may be insensitive to both intra-volume and inter-volume motion that is revealed by displacement of the slices. We developed the first slice-by-slice self-navigated motion monitoring system for fMRI by developing a real-time slice-to-volume registration (SVR) algorithm. Our real-time SVR algorithm, which is the core of the system, uses a local image patch-based matching criterion along with a Levenberg-Marquardt optimizer, all accelerated via symmetric multi-processing, with interleaved and simultaneous multi-slice acquisition schemes. Extensive experimental results on real motion data demonstrated that our fast motion monitoring system, named Slice Localization Integrated MRI Monitoring (SLIMM), provides more accurate motion measurements than a VVR based approach. Therefore, SLIMM offers improved online motion monitoring which is particularly important in fMRI for challenging patient populations. Real-time motion monitoring is crucial for online data quality control and assurance, for enabling feedback to the subject and the operator to act to mitigate motion, and in adaptive acquisition strategies that aim to ensure enough data of sufficient quality is acquired without acquiring excess data.
Lack in Periodontal Care of Patients Suffering from Severe Heart Diseases—Results after 12 Months Follow-Up (2020)

Eighty-eight participants (HTx: 31, LVAD: 43, HF: 14) were included. The majority of patients (79.5%) followed the recommendation to visit their dentist. Within the total cohort, periodontal treatment need was significantly reduced from 91% (baseline) to 75% (follow-up; <i>p</i> < 0.01). Only 10% of total cohort stated that they received periodontal treatment. The outcome in periodontal and dental treatment need at follow-up appointment revealed no statistically significant associations to the questionnaire regarding dentist consultation (<i>p</i> > 0.05). Conclusions<b>:</b> The simple recommendation to visit the dentist appears not enough to obtain sufficient dental and periodontal conditions in patients with severe heart diseases. Thereby, a lack in periodontal treatment of patients with HF, HTx and LVAD was identified, making interdisciplinary dental special care programs recommendable.
Facile and Robust Production of Ultrastable Micrometer-Sized Foams (2023)

Stable foams that can resist disproportionation for extended periods of time have important applications in a wide range of technological and consumer materials. Yet, legislative initiatives limit the range of surface active materials that can be used for environmental impact reasons. There is a need for technologies to efficiently produce multiphase materials using more eco-friendly components, such as particles, and for which traditional thermodynamics-based processing routes are not necessarily efficient enough. This work describes an innovative foaming technology that can produce ultrastable Pickering-Ramsden foams, with bubbles of micrometer-sized dimensions, through pressure-induced particle densification. Specifically, aqueous nanosilica-stabilized foams are produced by foaming a suspension at subatmospheric pressures, allowing for adsorption of the particles onto large bubbles. This is followed by an increase back to atmospheric pressure, which induces bubble shrinkage and compresses the adsorbed particle interface, forming a strong elastoplastic network that provides mechanical resistance against disproportionation. The foam’s interfacial mechanical properties are quantified to predict the range of processing conditions needed to produce permanently stable foams, and a general stability criterion is derived by considering the interfacial rheological properties under slow, unidirectional compression. Foams that are stable against disproportionation are characterized by interfaces whose mechanical resistance to compressive deformations can withstand their tendency to minimize the interfacial stress by reducing their surface area. Our ultrastable nanosilica foams are tested in real-life applications by introducing them into concrete. In comparison to other commercial air entrainers, our microfoam improves concrete’s freeze–thaw resistance while supplying higher material strength, providing an economically attractive, industrially scalable, and durable alternative for use in real-life applications involving cementitious materials. The applicability of our stability criterion to other rheologically complex interfaces and the versatile nature of our foaming technology enables usage for a broad class of materials, beyond the construction industry.
A Highly Conductive and Thermally Stable Ionic Liquid Gel Electrolyte for Calcium-Ion Batteries (2020)

Calcium-ion batteries are promising alternatives for post-lithium-ion batteries. However, their progress remains limited by challenges associated with the development of stable and effective electrolytes. We report for the first time an ionic liquid polymer gel membrane as both the electrolyte and the separator for use in a calcium-ion battery operating at room temperature. The membrane is prepared via single-step photo-cross-linking of poly(ethylene glycol) diacrylate in the presence of calcium salt dissolved in an ionic liquid and shows room temperature ionic conductivities between 10–4 and 10–3 S/cm, ∼4 V stability vs Ca/Ca2+, a cationic transference number of 0.17, high thermal stability up to ∼300 °C, and full dissociation of the calcium salts in the ionic liquid. A prototype battery demonstrates intercalation-based room-temperature operation, delivering a promising initial discharge capacity of ∼140 mAh/g.
Algorithms for creating indexes for very large tables without quiescing updates (1992)

As relational DBMSs become more and more popular and as organizations grow, the sizes of individual tables are increasing dramatically. Unfortunately, current DBMSs do not allow updates to be performed on a table while an index (e.g., a B+-tree) is being built for that table, thereby decreasing the systems' availability. This paper describes two algorithms in order to relax this restriction. Our emphasis has been to maximize concurrency, minimize overheads and cover all aspects of the problem. Builds of both unique and nonunique indexes are handled correctly. We also describe techniques for making the index-build operations restartable, without loss of all work, in case a system failure were to interrupt the completion of the creation of the index. In this connection, we also present algorithms for making a long sort of operation restartable. These include algorithms for the sort and merge phases of sorting.
Part-Per-Billion Level Chemical Sensing with a Gold-Based SERS-Active Substrate (2022)

We used surface-enhanced Raman spectroscopy (SERS) for the rapid and sensitive detection and quantification of caffeine in solution. Such a technique incorporated into a portable device is finding wide applications in trace chemical analysis in various fields, including law enforcement, medicine, environmental monitoring, and food quality control. To realize such applications, we are currently developing portable and handheld trace chemical analyzers based on SERS, which are integrated with a sensor embedded with activated gold nanoparticles in a porous glass matrix. In this study, we used this gold SERS-active substrate to measure aqueous solutions of the drug caffeine as a test chemical to benchmark sensor performance by defining sensitivity (lowest measured concentration (LMC) and estimated limit of detection (LOD)), determining concentration dependence and quantification capabilities by constructing calibration curves; by evaluating the effects of pH values of 3, 7, and 11; and by examining the reproducibility of the SERS measurements. The results demonstrate that the SERS sensor is sensitive, with caffeine detected at an LMC of 50 parts per billion (ppb) with an LOD of 0.63 ppb. The results further show that the sensor is very stable and can be used to make reproducible measurements, even under extremely acidic to basic pH conditions. Vibrational assignments of all observed SERS peaks are made and reported for the first time for caffeine on a gold substrate.
A Low-Complexity Approach for the Color Display of Hyperspectral Remote-Sensing Images Using One-Bit-Transform-Based Band Selection (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a new approach for the color display of hyperspectral images. It is proposed to use the one-bit transform (1BT) of hyperspectral image bands to select three suitable bands for red, green, and blue (RGB) display. The proposed approach has low complexity and is very suitable for hardware implementation. A dedicated hardware architecture that computes the transitions in the 1BT of hyperspectral image bands to determine bands that contain more information and the corresponding field-programmable gate array implementation of the proposed architecture are presented. In the proposed approach, less-structured bands are initially eliminated using the total number of transitions in the 1BT of hyperspectral image bands. Then, three suitable bands are selected from within this remaining set of well-structured bands for RGB color display. The proposed approach provides a new method for facilitating the color display of hyperspectral images, which has very low complexity. </para>
Bearing envelope analysis window selection Using spectral kurtosis techniques (2011)

Envelope Analysis is a well-known signal processing technique for bearing fault detection. However, improper window selection can result in poor fault detection performance. Using a known fault data set, we quantify the performance of spectral kurtosis (SK) and envelope kurtosis (EK) as a technique for setting an optimal frequency and bandwidth window for the envelope analysis. We establish a measure of effectiveness (MOE): the correlation of fault energy with total spall length. With this MOE, we evaluate the ability of SK/EK to predict the optimal envelope analysis window.
Disentangling the biological and environmental control of M. edulis shell chemistry (2011)

Blue mussel individuals ( Mytilus edulis ) were cultured at four different salinities (17, 20, 29, and 34). During the course of the experiment, temperature was gradually increased from 6°C to 14°C. Mg/Ca and Sr/Ca ratios of the shell calcite portions produced during the 9 weeks of experimental treatment as well parts that were precipitated before the treatment phase were measured by laser ablation–multicollector–inductively coupled plasma–mass spectrometry. Mg/Ca ratios show a positive correlation with temperature for individuals cultured at salinity 29 and 34 (Mg/Ca (mmol/mol) ∼ (0.2–0.3)*T (°C)), while for individuals cultured at low salinities (17, 20) no trend was observed. Sr/Ca ratios were not affected by temperature but strongly by salinity. The data show very strong biological influence (“individual differences” and “physiological variability”) on elemental ratios (79% on Mg/Ca and 41% on Sr/Ca) in M. edulis calcite. The results challenge the use of blue mussel shell data as environmental proxies.
Increased Glutathione Synthesis through an ARE-Nrf2–Dependent Pathway by Zinc in the RPE: Implication for Protection against Oxidative Stress (2006)

Induction of the ARE-Nrf2 pathway by zinc provides powerful and prolonged antioxidation and detoxification that may explain the beneficial effects of zinc observed in the treatment of age-related macular degeneration (AMD).
A design of real-time traffic sensitive CSAT access control frame for unlicensed LTE operations (2016)

The incredible traffic increasing of wireless systems causes the serious radio resource shortage. The utilization of unlicensed frequency bands can be an effective resource expansion to various wireless system. The sharing radio resource with Wi-Fi is an essential part of unlicensed LTE. Applying different structures between LTE and Wi-Fi, we propose a real-time traffic sensitive CSAT frame that adopts an adaptive Almost Blank Subframe (ABS) operation. The unlicensed LTE simulator shows the applicability of the proposed control frame for delay sensitive VoIP traffic while achieving the relatively high UDP data traffic throughput.