gebhart/patrepeval huggingface dataset:
Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells (2021)

Oxidative metabolism is crucial for leukemic stem cell (LSC) function and drug resistance in acute myeloid leukemia (AML). Mitochondrial metabolism also affects the immune system and therefore the anti-tumor response. The modulation of oxidative phosphorylation (OxPHOS) has emerged as a promising approach to improve the therapy outcome for AML patients. However, the effect of mitochondrial inhibitors on the immune compartment in the context of AML is yet to be explored. Immune checkpoints such as ectonucleotidase CD39 and programmed dead ligand 1 (PD-L1) have been reported to be expressed in AML and linked to chemo-resistance and a poor prognosis. In the present study, we first demonstrated that a novel selective electron transfer chain complex (ETC) I inhibitor, EVT-701, decreased the OxPHOS metabolism of murine and human cytarabine (AraC)-resistant leukemic cell lines. Furthermore, we showed that while AraC induced an immune response regulation by increasing CD39 expression and by reinforcing the interferon-γ/PD-L1 axis, EVT-701 reduced CD39 and PD-L1 expression in vitro in a panel of both murine and human AML cell lines, especially upon AraC treatment. Altogether, this work uncovers a non-canonical function of ETCI in controlling CD39 and PD-L1 immune checkpoints, thereby improving the anti-tumor response in AML.
Evaluation of corneal endothelium before and after neodymium : Yttrium-aluminium-garnet laser capsulotomy in posterior capsular opacification (2013)

Imaging plays an important role in diagnosing most orbital conditions. Imaging modalities commonly employed in orbital imaging are ultrasound, computed tomography, and magnetic resonance imaging. Conventional radiography plays a small role in imaging the orbits, particularly in rural areas in low-income countries such as Sudan. In this review, we will classify orbital conditions according to the systemic surgical sieve. Ophthalmologists need to understand the role and nature of each imaging modality to use the most appropriate investigation for a particular patient or condition. When requesting an imaging study, the radiologist needs to get full clinical information, including the surgical history, previous investigations, and a well-formulated question regarding what the clinician expects and wants.
Initial Upgrade of the ATLAS Level 1 Calorimeter Trigger (2015)

The Level-1 calorimeter trigger (L1Calo) of the ATLAS experiment has been operating well since the start of Large Hadron Collider (LHC) data taking, and played a major role in the Higgs boson discovery. To face the new challenges posed by the upcoming increases of the LHC proton beam energy and luminosity, a series of upgrades is planned for the L1Calo. This paper presents the first L1Calo upgrade program for the initial upgrade phase in 2013-14. The program includes substantial improvements to the analogue and digital signal processing. Two existing digital algorithm processor subsystems will receive substantial hardware and firmware upgrades, allowing topological information to be transmitted and processed. An entirely new subsystem, the L1 topological processor, will receive real-time data from both the upgraded L1Calo and L1 muon trigger to perform trigger algorithms based on entire event topologies. The expected performance improvements are described together with the upgraded hardware and firmware implementations.
Identification and Clinical Relevance of Naturally Occurring Human CD8+HLA-DR+ Regulatory T Cells (2014)

The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be cell-to-cell contact dependent and may involve CTLA-4 signaling between neighboring T cells. These regulatory T cells can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8(+)HLA-DR(+) T cells. The high frequency of CD8(+)HLA-DR(+) T cells that we detected in patients with non-small cell lung cancer deserves further work to confirm their putative suppressor effect within the tumor.
Novel functional properties of Ca2+ channel β subunits revealed by their expression in adult rat heart cells (2002)

Recombinant adenoviruses were used to overexpress green fluorescent protein (GFP)-fused auxiliary Ca(2+) channel beta subunits (beta(1)-beta(4)) in cultured adult rat heart cells, to explore new dimensions of beta subunit functions in vivo. Distinct beta-GFP subunits distributed differentially between the surface sarcolemma, transverse elements, and nucleus in single heart cells. All beta-GFP subunits increased the native cardiac whole-cell L-type Ca(2+) channel current density, but produced distinctive effects on channel inactivation kinetics. The degree of enhancement of whole-cell current density was non-uniform between beta subunits, with a rank order of potency beta(2a) approximately equal to beta(4) > beta(1b) > beta(3). For each beta subunit, the increase in L-type current density was accompanied by a correlative increase in the maximal gating charge (Q(max)) moved with depolarization. However, beta subunits produced characteristic effects on single L-type channel gating, resulting in divergent effects on channel open probability (P(o)). Quantitative analysis and modelling of single-channel data provided a kinetic signature for each channel type. Spurred on by ambiguities regarding the molecular identity of the actual endogenous cardiac L-type channel beta subunit, we cloned a new rat beta(2) splice variant, beta(2b), from heart using 5' rapid amplification of cDNA ends (RACE) PCR. By contrast with beta(2a), expression of beta(2b) in heart cells yielded channels with a microscopic gating signature virtually identical to that of native unmodified channels. Our results provide novel insights into beta subunit functions that are unattainable in traditional heterologous expression studies, and also provide new perspectives on the molecular identity of the beta subunit component of cardiac L-type Ca(2+) channels. Overall, the work establishes a powerful experimental paradigm to explore novel functions of ion channel subunits in their native environments.
Large-Eddy Simulation of Roughened NACA65 Compressor Cascade (2017)

Large eddy simulations over a NACA65 compressor cascade with roughness were performed for multiple roughness heights. The experiments show flow separation as airfoil roughness is increased. In LES computations, surface roughness was represented by regularly arranged discrete elements using guidelines from Schlichting. Results from wall-resolved LES indicate that specifying an equivalent sandgrain roughness height larger than the one in experiments is required to reproduce the same effects observed in experiments. This highlights the persisting uncertainty with matching the experimental roughness geometry in LES computations, pointing towards surface imaging and digitization as a potential solution. Some initial analysis of flow physics has been conducted with the aim of guiding the RANS modeling for roughness.
Formal verification of PLC controlled systems using Sensor Graphs (2009)

This paper describes how a system, consisting of a discrete controller (e.g. a PLC) that controls a physical plant/process, can be formally verified. The physical process is assumed to be modeled using <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Sensor</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Graphs</i> , a discrete event modeling language directed at physical systems with binary and identity sensors (e.g. RFID). The formal and graphical syntaxes of Sensor Graphs are presented and exemplified. The ldquosemitimedrdquo semantics is defined considering a process model together with a controller model, represented as a discrete state equation. Finally, it is shown how requirements on the closedloop system, represented by a sensor graph and a controller model, can be verified using the model checker Cadence SMV.
Phosphorus and calcium retention in steers fed a roughage diet is influenced by dietary 25OH-vitamin D (2012)

Active absorption of phosphorus (P) from the alimentary tract is promoted by increased concentrations of active vitamin D [1,25(OH)2D3] in blood; however, the production of this active vitamin is determined by plasma concentrations of calcium (Ca) and not P. As a consequence, diets of adequate Ca content, but insufficient P, will not promote active P absorption. Dietary supplements of 25OH-vitamin D (25OHD), the precursor of 1,25(OH)2D3, may stimulate P absorption and P retention of ruminants consuming diets marginally deficient in P. To evaluate this hypothesis, steers (n = 18) were fed a pelleted low-quality roughage diet containing an adequate Ca concentration (0.68%). Nine steers received a supplement of 25OHD mixed into their feed, at a rate of 3.25 mg/head.day, before pelleting. The other nine steers were fed the Control diet without supplementation. All steers were individually housed for 10 days before being moved into metabolism crates for a further 3-day period. The steers which received the diet containing 25OHD exhibited increased retention of P and Ca, ~4 and 3 g/day, respectively. Blood samples were taken before the adaptation period and then daily during the period in the metabolism crates. Plasma concentrations of both P and Ca were increased by 25OHD supplementation throughout the collection period. Addition of 25OHD to the diet of grazing animals may reduce the need for P supplementation programs and improve productivity.
HOMOGENOUS HYDROGENATION USING OSMIUM COMPLEXES (1974)

Abstract Os(II)ClH(PPh3)3 (I) was generated and its catalytic properties were investigated. Solutions of 1 catalysed the hydrogenation of 1-alkenes, and of some internal alkenes with activated double bonds. Stereoselective cis addition of hydrogen was demonstrated with suitable model compounds. In some cases the hydrogenation reaction was accompanied by cis-trans or positional isomerization. Some reactions of 1 are reported and the nmr data of 1 and related complexes are presented.
Bone conduction responses of middle ear structures in Thiel embalmed heads (2015)

Thiel-embalmed human whole-head specimens offer a promising alternative model for bone conduction (BC) studies of middle ear structures. In this work we present the Thiel model's linearity and stability over time as well as its possible use in the study of a fixed ossicle chain. Using laser Doppler vibrometry (LDV), the motion of the retroauricular skull, the promontory, the stapes footplate and the round window (RW) were measured. A bone-anchored hearing aid stimulated the ears with step sinus tones logarithmically spread between 0.1 and 10 kHz. Linearity of the model was verified using input levels in steps of 10 dBV. The stability of the Thiel model over time was examined with measurements repeated after hours and weeks. The influence of a cement-fixed stapes was assessed. The middle ear elements measured responded linearly in amplitude for the applied input levels (100, 32.6, and 10 mV). The variability of measurements for both short-(2 h) and long-term (4-16 weeks) repetitions in the same ear was lower than the interindividual difference. The fixation of the stapes induced a lowered RW displacement for frequencies near 750 Hz (-4 dB) and an increased displacement for frequencies above 1 kHz (max. +3.7 dB at 4 kHz). LDV assessment of BCinduced middle ear motion in Thiel heads can be performed with stable results. The vibratory RW response is affected by the fixation of the stapes, indicating a measurable effect of ossicle chain inertia on BC response in Thiel embalmed heads.
[2.2]Paracyclophane as a bridging unit in the design of organic dyes for sensitized solar cells (2011)

Organic dyes consisting of a [2.2]paracyclophane unit along the main chromophore are examined for their application in sensitized solar cells. These materials exhibit considerably high values of open-circuit voltage (V(oc)) ranging 0.69-0.72 V, and an overall efficiency up to 3.8%.
Selective mGluR5 antagonists MPEP and SIB‐1893 decrease NMDA or glutamate‐mediated neuronal toxicity through actions that reflect NMDA receptor antagonism (2000)

1. The metabotropic glutamate receptors (mGluRs) are a family of G-protein linked receptors that can be divided into three groups (group I, II and III). A number of studies have implicated group I mGluR activation in acute neuronal injury, but until recently it was not possible to pharmacologically differentiate the roles of the two individual subunits (mGluR1 and mGluR5) in this group. 2. We investigated the role of mGluR5 in acute NMDA and glutamate mediated neurodegeneration in cultured rat cortical cells using the mGluR5 antagonists MPEP and SIB-1893, and found that they provide significant protection at concentrations of 20 or 200 microM. 3. These compounds act as effective mGluR5 antagonists in our cell culture system, as indicated by the ability of SIB-1893 to prevent phosphoinositol hydrolysis induced by the specific mGluR5 agonist, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG). 4. However, they also significantly reduce NMDA evoked current recorded from whole cells voltage clamped at -60 mV, and significantly decrease the duration of opening of NMDA channels recorded in the outside out patch configuration. 5. This suggests that although MPEP and SIB-1893 are effective mGluR5 antagonists, they also act as noncompetitive NMDA receptor antagonists. Therefore, the neuroprotective effects of these compounds are most likely mediated through their NMDA receptor antagonist action, and caution should be exercised when drawing conclusions about the roles of mGluR5 based on their use.
Moulding techniques in lipstick manufacture: a comparative evaluation (1980)

Synopsis This paper examines two methods of lipstick bulk manufacture: one via a direct method and the other via stock concentrates. The paper continues with a comparison of two manufactured bulks moulded in three different ways - first by split moulding, secondly by Rotamoulding, and finally by Ejectoret moulding. Full consideration is paid to time, labour and cost standards of each approach and the resultant moulding examined using some novel physical testing methods. The results of these tests are statistically analysed. Finally, on the basis of the gathered data and photomicrographical work a theoretical lipstick structure is proposed by which the results may be explained.
Platform-based Shear Force Sensor (2015)

In this paper, we will present the development of a flexible fiber optic bend loss sensor for the measurement of plantar pressure and shear stress for diabetic patients. The sensor will allow the measurement of shear stress on the foot, which is a critical parameter in studying diabetic foot ulcers. The basic configuration of the optical sensor systems incorporates a mesh that is comprised of two sets of parallel optical waveguide planes; the planes are configured so the parallel rows of waveguides of the top and bottom planes are perpendicular to each other. The planes are sandwiched together creating one sensing sheet. Two-dimensional information is determined by measuring the loss of light from each of the waveguide to map the overall pressure distribution. The shifting of the layers relative to each other produces different patterns of the sensor output, and shear force information is characterized through repeated training of the sensor and analysis of the training data. The latest development and improvement in the sensors design is presented. Fabrication and sensor characterization results will be presented.
NATIONAL TRANSPLANTATION PREGNANCY REGISTRY—OUTCOMES OF 154 PREGNANCIES IN CYCLOSPORINE-TREATED FEMALE KIDNEY TRANSPLANT RECIPIENTS (1994)

Outcomes of pregnancies from 115 female kidney transplant recipients maintained on cyclosporine before and during pregnancy were obtained from questionnaires, hospital records, and telephone interviews. The mean age of conception was 29 years with a mean transplant interval of 2.2 years. There were 156 outcomes (2 sets of twins): ectopic 1%, therapeutic abortion 12%, miscarriage 16%, stillborn 2.6%, live birth 68.6%. The incidence of prematurity (< 37 weeks) was 56%, and that of low birthweight (< 2500 g) 49.5%. Complications occurred in 21.7% of newborns, but with only 1 neonatal death. Liveborn infants had a mean gestational age of 35.6 weeks (term 37-42 weeks) and a mean birthweight of 2407 g. The incidence of drug-treated hypertension prior to pregnancy was 51.7%; of diabetes prior to pregnancy, 11.7%; of preeclampsia, 24.8%; and of rejection during pregnancy or within 3 months postdelivery 14.5%. When infants born to women with or without a given risk factor were compared, mothers with pregnancy drug-treated hypertension had significantly lower-birth-weight infants (2250 vs. 2603 g, P = 0.028 by Wilcoxon). Similarly, mothers with prepregnancy creatinine > or = 1.5 mg/dl had smaller infants (2090 vs. 2505 g, P = 0.031 by Wilcoxon). There was a trend toward lower birth-weight in infants of diabetic recipients. Of 107 recipients interviewed, 12(11%) experienced graft loss, 8 associated with graft dysfunction or rejection during pregnancy. There was 1 graft loss during pregnancy due to rejection and 8 grafts were lost within 2 years of the pregnancy. There was one maternal death 4.3 years postpregnancy. For the 8 recipients who lost their graft within 2 years of pregnancy, outcomes included 1 miscarriage and 7 live births. The 7 live births had a mean gestational age of 35.7 weeks and a mean birth-weight of 2194 g. Five of 8 recipients who had graft loss within 2 years of pregnancy were in the drug-treated hypertensive group. Prepregnancy factors that appear to increase the risk to the newborn of a female kidney transplant recipient include maternal drug-treated hypertension, diabetes, and serum creatinine > or = 1.5 mg/dl. More data are needed before specific prepregnancy predictors for maternal graft loss can be determined in this population.
Alpha-Melanocyte Stimulating Hormone Promotes Regrowth of Injured Axons in the Adult Rat Spinal Cord (1999)

Peptides related to melanotropin (alphaMSH) and corticotropin (ACTH), collectively termed melanocortins, are known to improve the postlesion repair of injured peripheral nerves. In addition, melanocortins exert trophic effects on the outgrowth of neurites from central nervous system neurons in vitro. Here we report, for the first time, the stimulation by alpha-MSH of spinal neurite outgrowth in vivo after injury. In the in vivo model, spinal cord trauma was produced at lower thoracic spinal levels of adult rats. Under a surgical microscope a laminectomy was performed exposing the dorsum of the spinal cord. Then the dura was cut longitudinally and the dorsal columns were identified. Iridectomy scissors were used to transect the dorsal half of the spinal cord bilaterally, thereby completely lesioning the main corticospinal tract component. Then the lesion gap was immediately filled with a solid collagen matrix. Ingrowth of fibers was quantified using an advanced image analyser using a video image of sections transmitted by a camera. In the control situation virtually no ingrowth of sprouting injured fibers into the collagen implant in the lesion gap was seen. However, when the collagen matrix contained 10(-8) M alpha-MSH, a profound and significant stimulation of fiber ingrowth into the implant was observed (alpha-MSH, 21.5 +/- 2.9%; control, 1.4 +/- 0.6% p < 0.01). A small percentage of these ingrowing fibers was CGRP-immunoreactive (17.0 +/- 4%), whereas no serotonergic ingrowth was observed. Furthermore, we found that local application of alpha-MSH directs a substantial amount of lesioned anterogradely labelled corticospinal tract axons to regrow into the collagen implant (alpha-MSH, 15.2 +/- 5.2%; control, 0.5 +/- 0.3%, p < 0.01). The observed fiber ingrowth is not accompanied by an invasion of astroglial or reactive microglial cells into the implant. In conclusion, inclusion of alpha-MSH in the collagen implant stimulates the regrowth of injured axons in the adult rat spinal cord.
Towards the Web of Embeddings: Integrating multiple knowledge graph embedding spaces with FedCoder (2022)

The Semantic Web is distributed yet interoperable: Distributed since resources are created and published by a variety of producers, tailored to their specific needs and knowledge; Interoperable as entities are linked across resources, allowing to use resources from different providers in concord. Complementary to the explicit usage of Semantic Web resources, embedding methods made them applicable to machine learning tasks. Subsequently, embedding models for numerous tasks and structures have been developed, and embedding spaces for various resources have been published. The ecosystem of embedding spaces is distributed but not interoperable: Entity embeddings are not readily comparable across different spaces. To parallel the Web of Data with a Web of Embeddings, we must thus integrate available embedding spaces into a uniform space. Current integration approaches are limited to two spaces and presume that both of them were embedded with the same method — both assumptions are unlikely to hold in the context of a Web of Embeddings. In this paper, we present FedCoder— an approach that integrates multiple embedding spaces via a latent space. We assert that linked entities have a similar representation in the latent space so that entities become comparable across embedding spaces. FedCoder employs an autoencoder to learn this latent space from linked as well as non-linked entities. Our experiments show that FedCoder substantially outperforms state-of-the-art approaches when faced with different embedding models, that it scales better than previous methods in the number of embedding spaces, and that it improves with more graphs being integrated whilst performing comparably with current approaches that assumed joint learning of the embeddings and were, usually, limited to two sources. Our results demonstrate that FedCoder is well adapted to integrate the distributed, diverse, and large ecosystem of embeddings spaces into an interoperable Web of Embeddings.
Synthese von Hetaryl‐ und Hetarylvinylphosphonsäureestern aus 2‐Brom‐1‐oxoalkylphosphonaten und 4‐Brom‐3‐oxo‐1‐alkenylphosphonaten (1984)

Abstract 3‐Oxo‐1‐alkenylphosphonate 1 werden mit NBS zu den (Bromacyl)vinyl‐Derivaten 2 , Acylphosphonsäureester 3 mit Brom zu den α‐Bromacylphosphonaten 4 umgesetzt. Letztere reagieren mit Thioacetamid und Thioharnstoff zu den Thiazolylphosphonaten 7 bzw. 8 , mit 2‐Pyridylessigester zu den Indolizinylphosphonaten 15 , mit 2‐Aminopyridin zu den Imidazo[1,2‐ a ]pyridinylphosphonaten 16 , mit 2‐Aminopyrimidin bzw. 2‐Amino‐4,6‐dimethylpyrimidin zu den Imidazo‐[1,2‐ a ]pyrimidinyl‐Systemen 17 bzw. 18. – Aus den 4‐Brom‐3‐oxoalkenylphosphonaten 2 werden nach dem gleichen Reaktionsprinzip entsprechende vinyloge Thiazole 9 und 10 , Indolizine 19 , Imidazo[1,2‐ a ]pyrimidine 20 und Imidazo[1,2‐ a ]pyrimidine 21 erhalten. Kondensation mit Cytosin liefert die Imidazo[1,2‐ c ]pyrimidine 24.