gebhart/patrepeval huggingface dataset:
Control of Surface Functional Groups on Pertechntate Sorption on Activated Carbon (2006)

{sup 99}Tc is highly soluble and poorly adsorbed by natural materials under oxidizing conditions, thus being of particular concern for radioactive waste disposal. Activated carbon can potentially be used as an adsorbent for removing Tc from aqueous solutions. We have tested six commercial activated carbon materials for their capabilities for sorption of pertechnetate (TcO{sub 4}{sup -}). The tested materials can be grouped into two distinct types: Type I materials have high sorption capabilities with the distribution coefficients (K{sub d}) varying from 9.5 x 10{sup 5} to 3.2 x 10{sup 3} mL/g as the pH changes from 4.5 to 9.5, whereas type II materials have relatively low sorption capabilities with K{sub d} remaining more or less constant (1.1 x 10{sup 3} - 1.8 x 10{sup 3} mL/g) over a similar pH range. The difference in sorption behavior between the two types of materials is attributed to the distribution of surface functional groups. The predominant surface groups are identified to be carboxylic and phenolic groups. The carboxylic group can be further divided into three subgroups A, B, and C in the order of increasing acidity. The high sorption capabilities of type I materials are found to be caused by the presence of a large fraction of carboxylic subgroups A and B, while the low sorption capabilities of type II materials are due to the exclusive presence of phenolic and carboxylic subgroup C. Therefore, the performance of activated carbon for removing TcO{sub 4}{sup -} can be improved by enhancing the formation of carboxylic subgroups A and B during material processing.
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes (2023)

Substituted arenes are ubiquitous in molecules with medicinal functions, making their synthesis a critical consideration when designing synthetic routes. <sup>1,2</sup> Regioselective C-H functionalization reactions are attractive for preparing alkylated arenes, <sup>3-5</sup> however, the selectivity of existing methods is modest and primarily governed by substrate electronic properties. <sup>6,7</sup> Here, we demonstrate a biocatalyst-controlled method for the regioselective alkylation of electron-rich and electron-deficient heteroarenes. Starting from an unselective 'ene'-reductase (ERED) (GluER-T36A), we evolved a variant that selectively alkylates the C4 position of indole, an elusive position using prior technologies. Mechanistic studies across the evolutionary series indicate that changes to the protein active site alter the electronic character of the charge transfer (CT) complex responsible for radical formation. This resulted in a variant with a significant degree of ground state change transfer in the CT complex. Mechanistic studies on a C2 selective ERED suggest that the evolution of GluER-T36A helps disfavor a competing mechanistic pathway. Additional protein engineering campaigns were carried out for a C8 selective quinoline alkylation. This study highlights the opportunity to use enzymes for regioselective reactions where small molecule catalysts struggle to alter selectivity.
Innovative Six Sigma Design Using the Eigenvector Dimension-Reduction (EDR) Method (2007)

&lt;div class="htmlview paragraph"&gt;This paper presents an innovative approach for quality engineering using the Eigenvector Dimension Reduction (EDR) Method. Currently industry relies heavily upon the use of the Taguchi method and Signal to Noise (S/N) ratios as quality indices. However, some disadvantages of the Taguchi method exist such as, its reliance upon samples occurring at specified levels, results to be valid at only the current design point, and its expensiveness to maintain a certain level of confidence. Recently, it has been shown that the EDR method can accurately provide an analysis of variance, similar to that of the Taguchi method, but is not hindered by the aforementioned drawbacks of the Taguchi method. This is evident because the EDR method is based upon fundamental statistics, where the statistical information for each design parameter is used to estimate the uncertainty propagation through engineering systems. Therefore, the EDR method provides much more extensive capabilities than the Taguchi method, such as the ability to estimate not only mean and standard deviation of the response, but also the skewness and kurtosis. The uniqueness of the EDR method is its ability to generate the probability density function (PDF) of system performances. This capability, known as the probabilistic “what-if” study, provides a visual representation of the effects of the design parameters (e.g., its mean and variance) upon the response. In addition, the probabilistic “what-if” study can be applied across multiple design parameters, allowing the analysis of interactions among control factors. Because of these advantages, it is apparent that the EDR method provides an alternative platform of quality engineering to the Taguchi method. For easy execution by field engineers, the proposed platform for quality engineering using the EDR method, known as Quick Quality Quantification (Q&lt;sup&gt;3&lt;/sup&gt;), will be developed as a Microsoft EXCEL add-in.&lt;/div&gt;
Osmium-Promoted σ-Bond Activation Reactions on Nucleosides (2020)

OsH6(PiPr3)2 has been used to selectively activate C–H, O–H, and C–C sigma bonds in nucleobases and nucleosides, including derivatives of 6-phenylpurine and 4-phenylpyrimidine, leading to cyclometalated mononuclear Os–trihydride complexes, in excellent yields and as single products. Additionally, OsH6(PiPr3)2 promotes the efficient dehydrogenative decarbonylation of primary alcohols in nucleosides having unprotected sugar moieties. The incorporation of OsH2Cl2(PiPr3)2 in the structure of cyclometalated Ir(III) and Rh(III) half-sandwich complexes derived from nucleosides allows the preparation of a class of heterobimetallic bioorganometallic complexes having at least one M–C bond. These methodologies could be used in the future as a way for the orthogonal functionalization of oligonucleotides.
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism (1999)

The results indicate a significant association of UGT1A1 phenotype and genotype based on in vitro phenotypic measurements. The clinical significance of our finding remains to be established.
Acylation of Amino Acids by Aminoacylase in Non-Conventional Media (1994)

N-Acylation of amino acids by aminoacylase (EC 3.5.1.14) isolated from pig kidney was investigated. In water containing organic solutions native aminoacylase proved to be unsuitable for acylation reactions. Covalent immobilization enhanced the stability of aminoacylase in organic solvents (dimethylformamide and dioxane).The support gel beads showed extraordinary swelling behaviour in dimethylformamide solutions of different water content with respect to their liquid uptake and the temperature sensitivity of swelling.N-Acylation activity of immobilized enzyme proved to be sufficient in case of L-methionine as substrate and acetate as acylating agent. In addition, the peptide (Ala-Ala) formation was unambiguous but the reaction was much slower than acylation under the given conditions.
Deazaflavin photocatalyzed methyl viologen reduction in water. A laser flash-photolysis study (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeazaflavin photocatalyzed methyl viologen reduction in water. A laser flash-photolysis studyAntone J. W. G. Visser and Janos H. FendlerCite this: J. Phys. Chem. 1982, 86, 13, 2406–2409Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/j100210a031https://doi.org/10.1021/j100210a031research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Architecture support for single address space operating systems (1992)

article Free Access Share on Architecture support for single address space operating systems Authors: Eric J. Koldinger View Profile , Jeffrey S. Chase View Profile , Susan J. Eggers View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 27Issue 9Sept. 1992 pp 175–186https://doi.org/10.1145/143371.143508Published:01 September 1992Publication History 90citation1,561DownloadsMetricsTotal Citations90Total Downloads1,561Last 12 Months102Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Real-time prediction of length of stay using passive Wi-Fi sensing (2017)

The proliferation of wireless technologies in today's everyday life is one of the key drivers of the Internet of Things (IoT). In addition to being an enabler of connectivity, the vast penetration of wireless devices today gives rise to a secondary functionality as a means of tracking and localization of the devices themselves. Indeed, in order to discover and automatically connect to known Wi-Fi networks, mobile devices have to scan and broadcast the so-called probe requests on all available channels, which can be captured and analyzed in a non-intrusive manner. Thus, one of the key applications of this feature is the ability to track and analyze human behaviors in real-time directly from the patterns observed from their Wi-Fi-enabled devices. In this paper, we develop such a system to obtain these Wi-Fi signatures in a completely passive manner and use the Wi-Fi features it captures within a set of adaptive machine learning techniques to predict in real-time the expected length of stay (LOS) of the device owners at a specific location.
Renal glycerol metabolism and the distribution of glycerol kinase in rabbit nephron (1981)

Glycerol and dihydroxyacetone are metabolized by rabbit kidney-cortex tubules, isolated by collagenase treatment. Half-maximal concentrations of both substrates were determined with regard to uptake rates and product formations. Maximal uptake rates were 643 and 329 mumol/h per g of protein for dihydroxyacetone and glycerol respectively. Glucose and lactate were found as major metabolic products. Glycerol kinase, the enzyme catalysing the first step in renal glycerol and dihydroxyacetone metabolism, was measured radiochemically as described by Newsholme, Robinson & Taylor [(1967) Biochim, Biophys. Acta 132, 338-346] and adapted for studies of the localization of this enzyme along the different structures of rabbit nephron. The results show that glycerol kinase is located exclusively in the proximal segments, i.e. the proximal convoluted tubules and the pars recta, but is negligible in the other structures studied. The activities were close to the maximal dihydroxyacetone uptake rates measured in tubule suspensions.
A Fail-Safe Semi-Centralized Impedance Controller: Validation on a Parallel Kinematics Ankle (2018)

This paper proposes the implementation of an impedance controller on the ankle level of COMAN+, a robot with parallel kinematics ankles actuated by a dual four-bar mechanism. The main contribution of the work is a realization of said control scheme that grants a less abrupt and safer robot response in case of system failures, that would cause the local joint torque controllers to lose their torque reference inputs. In particular, we propose a semi-centralized impedance control implementation which eliminates the instability of the pure joint torque control schemes used in the classical fully centralized methods when torque reference interruptions occur. Finally, we present experimental results, proving the effectiveness of our method and demonstrating how it ensures a safer behaviour compared to a fully centralized impedance control implementation when the communication to the ankle joints is interrupted. This paper is a follow-up work of [1], which presented and analyzed the parallel kinematics ankles.
Heterochronies in the formation of the nervous and digestive systems in early postlarval development of opisthobranch mollusks: Organization of major organ systems of the arctic dorid Cadlina laevis (2015)

For the first time using laser confocal microscopy and histochemical and immunocytochemical methods (detection of F-actine, catecholamines, acetylcholintransferase, substances of P and FM RFamide) in combination with classical histological methods and electron microscopy of total preparations, the general structure and regularities of formation of the main organs and the nervous, muscular, and digestive systems in early postlarval development (2 to 4 months) in the opistobranch mollusk Cadlina laevis were studied. Heterochronies manifested in positive allometry of the sensory organs, ganglia of the central nervous system, and the pharyngeal region of the digestive system in relation to general body sizes in juvenile individuals compared to adult animals were detected.
Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover (2001)

The p53 tumour suppressor protein is a short-lived transcription factor that becomes stabilized in response to a wide range of cellular stresses. Ubiquitination and the targeting of p53 for degradation by the proteasome are mediated by Mdm2 (mouse double minute clone 2), a negative regulatory partner of p53. Previous studies have suggested that DNA-damage-induced phosphorylation of p53 at key N-terminal sites has a pivotal role in regulating the interaction with Mdm2 but the precise role of phosphorylation of serines 15 and 20 is still unclear. Here we show that replacement of serine 15 and a range of other key N-terminal phosphorylation sites with alanine, which cannot be phosphorylated, has little effect on the ubiquitination and degradation of full-length human p53. In contrast, replacement of serine 20 makes p53 highly sensitive to Mdm2-mediated turnover. These results define distinct roles for serines 15 and 20, two sites previously demonstrated to be dependent on phosphorylation through mechanisms mediated by DNA damage and ATM (ataxia telangiectasia mutated). We also show that the polyproline region of p53, a domain that has a key role in p53-induced apoptosis, exerts a critical influence over the Mdm2-mediated turnover of p53.
[Acute myocardial infarct in Switzerland: results from the PIMICS Heart Infarct Register. PIMICS Project (Prospective Ischemia Myocardial Infarction Captopril Survey)]. (1998)

The aim of the PIMICS project was to create, for the first time in Switzerland, a registry of data concerning epidemiology and therapy in patients hospitalised for acute myocardial infarction covering all regions of the country. During 1995/96 73 Swiss hospitals of all categories took part in the PIMICS project. The ratio between males and females in the 3877 registered patients was 2.6:1 (2791 men vs. 1086 women). Female patients were significantly older than males (70.4 +/- 12.0 years vs. 63.4 +/- 12.6 years; p < 0.0001). The prevalence of risk factors differed between men and women: significantly more women had hypertension or diabetes, whereas smoking was more prevalent in males. The median delay between onset of symptoms and arrival at the hospital was 5.5 hours. Thrombolysis and primary angioplasty were more frequently performed in men (40.4% vs. 31.2% in women, p < 0.0001, and 5.7% in men vs. 3.5% in women, p = 0.005 respectively). During the acute phase males were treated more frequently with betablockers. The overall in-hospital mortality was 9.1%. It was significantly higher in female patients (13.5% vs. 7.4% in men; p < 0.0001) and in patients with reinfarction (14.5% vs. 7.1%; p < 0.0001). The mean hospital stay was 12.6 +/- 5.3 days. Only 7.7% of all patients with acute myocardial infarction were discharged within 6 days. At discharge, 51.7% were treated with betablockers and 69.3% with aspirin; 44.8% received ACE-inhibitors and only 13.8% lipid-lowering drugs. Follow-up measures such as coronary angiography and/or angioplasty or bypass surgery were performed significantly more often in males (45.0% vs. 32.9%; p < 0.0001). Likewise, men were more frequently assigned to a rehabilitation program than women (38.2% vs. 32.9%; p = 0.0004). The pre-hospital delay in patients with acute myocardial infarction remains too long. Primary and secondary prevention should be intensified in high risk groups, particularly in females. Thrombolysis and primary angioplasty as mainstays of treatment in acute myocardial infarction are generally used too sparingly, especially in women. With such measures the hospital stay could be shortened further.
Modeling and analysis of the behavior of successive reactive programs (2015)

Finite state transducers extend the finite state automata to model functions on strings or lists. They may be used also as simple models of sequential reactive programs. These programs operate in the interaction with the environment permanently receiving data (requests) from it. At receiving a piece of data such program performs a sequence of actions. When certain control points are achieved a program outputs the current results of computation as a response. It is significant that different sequences of actions may yield the same result. Therefore, the basic actions of a program may be viewed as generating elements of some appropriate semigroup, and the result of computation may be regarded as the composition of actions performed by the program. This paper offers an alternative technique for the analysis of finite state transducers over semigroups. To check the equivalence of transducers and we associate with them a Labeled Transition Systems . Each path in this LTS represents all possible runs of and on the same input word. Every node of keeps track of the states of and achieved at reading some input word and the deficiency of the output words computed so far. If both transducers reach their final states and the deficiency of their outputs is nonzero then this indicates that and produce different images for the same word, and, hence, they are not equivalent. The nodes of that capture this effect are called rejecting nodes. Thus, the equivalence checking of and is reduced to checking the reachability of rejecting nodes in LTS . We show that one needs to analyze only a bounded fragment of to certify (un)reachability of rejecting nodes. The size of this fragment is polynomial of the size of and if both transducers are deterministic, and single-exponential if they are k-bounded. The same approach is applicable for checking k-valuedness of transducers over semigroups.
Supplementary Table 1 from MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer (2023)

&lt;p&gt;Supplementary Table 1: RT-qPCR primers sequences.&lt;/p&gt;
Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblasts (2010)

It can be concluded that these findings, together with upregulation in gene expression, show that it is possible to stimulate the cells to produce more collagen with short-pulsed heat shocks.
Quantitative Evaluation of Angular Measurements on Plain Radiographs in Patients With Slipped Capital Femoral Epiphysis (2008)

Level II; 23 consecutive patients with SCFE in the senior authors practice; evaluation of the reliability of angular measurements on plain radiographs; CT based 3D computer models of the same femora as a reference.
Compact Belief Rule Base Learning for Classification with Evidential Clustering (2019)

The belief rule-based classification system (BRBCS) is a promising technique for addressing different types of uncertainty in complex classification problems, by introducing the belief function theory into the classical fuzzy rule-based classification system. However, in the BRBCS, high numbers of instances and features generally induce a belief rule base (BRB) with large size, which degrades the interpretability of the classification model for big data sets. In this paper, a BRB learning method based on the evidential C-means clustering (ECM) algorithm is proposed to efficiently design a compact belief rule-based classification system (CBRBCS). First, a supervised version of the ECM algorithm is designed by means of weighted product-space clustering to partition the training set with the goals of obtaining both good inter-cluster separability and inner-cluster pureness. Then, a systematic method is developed to construct belief rules based on the obtained credal partitions. Finally, an evidential partition entropy-based optimization procedure is designed to get a compact BRB with a better trade-off between accuracy and interpretability. The key benefit of the proposed CBRBCS is that it can provide a more interpretable classification model on the premise of comparative accuracy. Experiments based on synthetic and real data sets have been conducted to evaluate the classification accuracy and interpretability of the proposal.
Regulation of insulin secretion: fuel hypothesis (1989)

info:eu-repo/semantics/published
Reconfigurable FSR-free microring resonator filter with wide hitless tunability (2021)

We present a novel design for a reconfigurable silicon microring resonator filter exploiting non-integer Vernier ratio to achieve FSR-free spectral response. Hitless tunability across the extended C+L band (1520 nm-1620 nm) is achieved by introducing controllable loss in the MRRs of the filter.
SLAM for Direct optimization based Visual-Inertial Fusion (2018)

The tightly coupled fusion of inertial sensors and direct visual odometry is extended by a SLAM approach in order to further improve the localization accuracy in case that places are revisited (loop closure). For that keyframes stored along the trajectory are used to represent the SLAM map. If the current position is close to a previously stored keyframe, the transformation to the current frame is calculated using the direct image alignment method. Depth information available from the stereo camera is used as additional measurement for better convergence. On successful calculation the current sensor system pose is corrected according to the found transform and by that the position errors are reduced significantly. Our online SLAM implementation is a filter based approach where the filter state is augmented by the keyframe poses in order to properly model uncertainties and correlation.