gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Chemistry of Inorganic Sulfonates and Sulfates of Polyvalent Iodine (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antenna Testing and Measurements (2005)

Abstract Although extensive modeling codes exist to predict antenna performance, no model can certify hardware without some obtaining representative patterns of the antenna as it will be used. Extensive facilities using various methods to evaluate antenna performance have been developed over many years. This article covers the accepted technologies that allow verification of design performance.
Studies on the Mechanism of Hybridization of Lactic Dehydrogenases in Vitro* (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the Mechanism of Hybridization of Lactic Dehydrogenases in Vitro*Oscar P. Chilson, Louis A. Costello, and Nathan O. KaplanCite this: Biochemistry 1965, 4, 2, 271–281Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://pubs.acs.org/doi/10.1021/bi00878a015https://doi.org/10.1021/bi00878a015research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal behaviour of germanium dioxide (1966)

The thermal behaviour of the two crystalline forms of germanium dioxide has been investigated by differential thermal analysis. Small amounts of lithium increase the rate of transformation. The enthalpy and entropy of transformation have been estimated as 5·05 ± 0·6 kcal. mole–1 and 3·9 ± 0·5 e.u., and the enthalpy of fusion as 4·1 ± 0·5 kcal. mole–1, at the respective transformation and fusion temperatures. Use of the available specific-heat data for both forms of germania to extrapolate to 298°K leads to a standard entropy of tetragonal germania of 9·7 ± 0·7 e.u.
[Rupture of the female urethra in fractures of the pelvic bones. Apropos of 2 new cases]. (1992)

Female urethra ruptures associated with pelvic ring fractures are exceptionally observed. The authors compared these 2 cases (Besançon and Toulon) to already published cases. This diagnosis must be contemplated and established by the surgeon or in his/her presence using urethral catheterization. The surgical approach (most of time abdominoperineal) allows an accurate injury repair and prevents from fearsome complications due to late diagnosis and treatment. An active attitude following this urological act is highly required, in case of osteoarticular injuries, whose instability and rules are currently known.
Extension of the Pierce Model to Multiple Transmission Lines Interacting With an Electron Beam (2014)

A possible route toward achieving high-power microwave (HPM) devices is through the use of novel slow-wave structures, represented by multiple coupled transmission lines (MTLs), and whose behavior when coupled to electron beams has not been sufficiently explored. We present the extension of the 1-D linearized Pierce theory to MTLs coupled to a single electron beam. We develop multiple formalisms to calculate the k-ω dispersion relation of the system and find that the existence of a growing wave solution is always guaranteed if the electron propagation constant is larger than or equal to the largest propagation constant of the MTL system. We verify our findings with illustrative examples that bring to light unique properties of the system in which growing waves were found to exist within finite bands of the electron propagation constant and also present possible means to improve the gain. By treating the beam-MTL interaction as distributed dependent current generators in the MTL, we derive relations characterizing the power flux and energy exchange between the beam and the MTLs. For the growing wave, we show that the beam always behaves as an energy source causing power flux along the transmission lines. The theory developed in this paper is the basis for the possible use of degenerate band edges in periodic MTL systems for HPM amplifiers.
Data from An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;AtezoTRIBE phase II randomized study demonstrated that adding atezolizumab to first-line FOLFOXIRI (5-fluorouracil, oxaliplatin, irinotecan) plus bevacizumab prolongs progression-free survival (PFS) of patients with metastatic colorectal cancer (mCRC), with a modest benefit among proficient mismatch repair (pMMR). DetermaIO is an immune-related 27-gene expression signature able to predict benefit from immune checkpoint inhibition in triple-negative breast cancer. In this analysis of AtezoTRIBE, we investigated the predictive impact of DetermaIO in mCRC.&lt;/p&gt;Experimental Design:&lt;p&gt;Patients with mCRC unselected for MMR status were randomly assigned (1:2) to FOLFOXIRI plus bevacizumab (control arm) or the same regimen with atezolizumab (atezolizumab arm). qRT-PCR by DetermaIO was performed on RNA purified from pretreatment tumors of 132 (61%) of 218 enrolled patients. A binary result (IO&lt;sup&gt;pos&lt;/sup&gt; vs. IO&lt;sup&gt;neg&lt;/sup&gt;) adopting the preestablished DetermaIO cut-off point (0.09) was obtained, and an exploratory optimized cut-off point (IO&lt;sup&gt;OPT&lt;/sup&gt;) was computed in the overall population and in pMMR subgroup (IO&lt;sup&gt;OPTpos&lt;/sup&gt; vs. IO&lt;sup&gt;OPTneg&lt;/sup&gt;).&lt;/p&gt;Results:&lt;p&gt;DetermaIO was successfully determined in 122 (92%) cases, and 23 (27%) tumors were IO&lt;sup&gt;pos&lt;/sup&gt;. IO&lt;sup&gt;pos&lt;/sup&gt; tumors achieved higher PFS benefit from atezolizumab arm than IO&lt;sup&gt;neg&lt;/sup&gt; (HR: 0.39 vs. 0.83; &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.066). In pMMR tumors (&lt;i&gt;N&lt;/i&gt; = 110), a similar trend was observed (HR: 0.47 vs. 0.93; &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.139). In the overall population, with the computed IO&lt;sup&gt;OPT&lt;/sup&gt; cut-off point (0.277), 16 (13%) tumors were IO&lt;sup&gt;OPTpos&lt;/sup&gt; and they derived higher PFS benefit from atezolizumab than IO&lt;sup&gt;OPTneg&lt;/sup&gt; (HR: 0.10 vs. 0.85, &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.004). Similar results were found in the pMMR subgroup.&lt;/p&gt;Conclusions:&lt;p&gt;DetermaIO may be useful to predict benefit of adding atezolizumab to first-line FOLFOXIRI plus bevacizumab in mCRC. The exploratory IO&lt;sup&gt;OPT&lt;/sup&gt; cut-off point should be validated in independent mCRC cohorts.&lt;/p&gt;&lt;/div&gt;
Chemistry of Alkoxy Radicals: Cleavage Reactions (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Alkoxy Radicals: Cleavage ReactionsJay K. KochiCite this: J. Am. Chem. Soc. 1962, 84, 7, 1193–1197Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://pubs.acs.org/doi/10.1021/ja00866a026https://doi.org/10.1021/ja00866a026research-articleACS PublicationsRequest reuse permissionsArticle Views1531Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Short-term genomic stability of Clostridium difficile within patients and a gut model (2011)

Background: Clostridium difficile (CD) whole genome sequencing (WGS) has potential to identify related isolates for transmission studies, even among otherwise indistinguishable strains, but depends on understanding the genomic variation within isolates and individuals. Methods: Serial isolates (n=11) were taken over 31 days from a triple stage chemostat human gut model inoculated with a CD NAP1/027 strain for WGS, including baseline, clindamycin exposure, toxin induction, and antibiotic treatment phases. Multiple isolates were also obtained for WGS from 10 patients (range 2-8 isolates per patient, n=29) with recurrent symptomatic NAP1/027 CD infection during 2007-09. Extracted DNA from each isolate was sequenced using the Illumina GA2 and HighSeq platforms and mapped to the CD196 reference genome using STAMPY. Base and variant calls were made using SAMTOOLS, PICARD and bespoke Python scripts. Results: The first 9 isolates from the gut model were identical by WGS. During antibiotic treatment, 1 single nucleotide variant (SNV) emerged and persisted in the subsequent isolate, introducing a non-synonymous change in the coding sequence for a glucose transport protein. WGS of 3 duplicate DNA extract pairs produced fully concordant data. In serially sampled patients, the median (IQR) time between baseline and subsequent tests was 76 (1-95) days. In 8 of the 10 patients no SNVs were observed up to a maximum of 192 days later. A single SNV occurred transiently in another patient after 82 days. Among 8 isolates from the final patient, 1 SNV occurred after 75 days and another the next day, and both persisted over the next 32 days. A further SNV was identified in a single sequence and not found in subsequent isolates. Conclusions: The consistency of WGS data for gut model CD isolates demonstrates the reliability of our sequencing and analysis techniques. The high stability of mapped genomic sequences in CD isolates from patients supports their use in detailed transmission studies
Estudio de la evolución de la velocidad deultrasonidos en probetas de hormigón condistintos grados de humedad (2011)

El hormigon es uno de los materiales mas utilizados en el mundo de la construccion y la ingenieria a lo largo de la Historia. El comportamiento y las propiedades de este material a lo largo del tiempo son objeto de numerosos estudios debido a las caracteristicas monoliticas y mecanicas que presenta y a la abundancia de sus componentes en la naturaleza. [1] Se ha realizado un estudio experimental sobre probetas cubicas de hormigon en masa (dimensiones: 10x10x10 cm) de la evolucion de la velocidad de propagacion de ultrasonidos (US) a traves del hormigon y el grado en que afectan distintas variables a dicha velocidad, y su posible relacion con su resistencia a compresion. Se han fabricado 32 probetas con hormigon H-25, tomando dos dosificaciones diferentes en cuanto a la relacion agua/cemento (A/C) (A/C=0,5 y A/C=0,6), y empleando dos tipos distintos de arido grueso. Sobre dichas probetas se han llevado a cabo medidas periodicas de velocidad de propagacion de US y del grado de humedad que adquieren durante el tiempo de curado en camara humeda y durante su endurecimiento en ambiente de laboratorio hasta su rotura a compresion. Tambien se las sometio a ensayos de rotura a compresion con el fin de determinar posibles dependencias entre la resistencia a rotura adquirida y la maxima deformacion experimentada con dicha velocidad de propagacion y contenido de humedad. [2] [3] Una vez realizados los ensayos, se puede observar un comportamiento respecto a la velocidad de propagacion a traves del hormigon. El ambiente al que se expone el hormigon es determinante a la hora de establecer correlaciones entre la velocidad y el contenido de humedad. En cuanto a la fase de ensayos destructivos, se observa una evolucion frente a esfuerzos de compresion similar, presentando una resistencia y un limite elastico un 16% aproximadamente superior en el hormigon con menor cantidad de humedad (relacion A/C=0,5).
Technology Advances for Prostate Biopsy and Needle Therapies (2012)

No AccessJournal of UrologyEditorial1 Oct 2012Technology Advances for Prostate Biopsy and Needle Therapies Dan Stoianovici Dan StoianoviciDan Stoianovici More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.06.127AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Technology Advances for Prostate Biopsy and Needle Therapies." The Journal of Urology, 188(4), pp. 1074–1075 References 1 : Cancer statistics, 2012. CA Cancer J Clin2012; 62: 10. Google Scholar 2 : Screening for prostate cancer—the controversy that refuses to die. N Engl J Med2009; 360: 1351. Google Scholar 3 : Challenges in clinical prostate cancer: role of imaging. AJR Am J Roentgenol2009; 192: 1455. Google Scholar 4 Han M, Kim C, Chang D et al: Geometric evaluation of systematic transrectal ultrasound-guided prostate biopsy. Unpublished data. Google Scholar 5 : Documenting the location of prostate biopsies with image fusion. BJU Int2011; 107: 53. Google Scholar 6 : Innovations in prostate biopsy strategies for active surveillance and focal therapy. Curr Opin Urol2011; 21: 115. Google Scholar 7 : Endocavity ultrasound probe manipulators. IEEE/ASME Trans Mechatron2012; 99: 1. Google Scholar 8 : Tandem-robot assisted laparoscopic radical prostatectomy to improve the neurovascular bundle visualization: a feasibility study. Urology2011; 77: 502. Google Scholar 9 : Robotic transperineal prostate biopsy: pilot clinical study. Urology2011; 78: 1203. Google Scholar 10 : Development of a novel robot for transperineal needle based interventions: focal therapy, brachytherapy and prostate biopsies. J Urol2012; 188. 1369. Google Scholar 11 : Does needle rotation improve lesion targeting?. Int J Med Robot2011; 7: 138. Google Scholar 12 : Transperineal prostate intervention: robot for fully automated MR imaging—system description and proof of principle in a canine model. Radiology2008; 247: 543. Google Scholar 13 : Robotic image-guided needle interventions of the prostate. Rev Urol2009; 11: 7. Google Scholar Robotics Laboratory, Urology Department, Johns Hopkins University, Baltimore, Maryland© 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 4October 2012Page: 1074-1075 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dan Stoianovici More articles by this author Expand All Advertisement PDF downloadLoading ...
Size heterogeneity of EBV and mitochondrial DNAs in Burkitt's lymphoma lines (1987)

A simple, reproducible affinity chromatography method has been adapted for separation of high molecular weight supercoiled circular molecules from mammalian cells. Electron microscopic analysis of EB viral DNA obtained by this method, from the non-producer Burkitt's lymphoma line Raji, revealed monomer-sized viral molecules only. In contrast, the EB viral episomes from recently established human producer lines BL-8 and LY91 were very heterogeneous in size, some being considerably smaller and others much larger than the monomeric DNA. The former are probably related to defective viral species in the B-cell population, but the origin of the latter are as yet unclear. All cell lines contained both monomers and concatemers of mitochondrial DNA; among the latter, molecules apparently greater than 100 kb were observed in the population.
Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides (2012)

<i>N</i>-Aryl-<i>O</i>-alkylhydroxamic acid derivatives were prepared by copper-catalyzed cross-coupling of hydroxamates with aryl iodides. The reaction conditions are compatible with standard hydroxy-protecting groups on the hydroxylamine moiety and are applicable to a broad range of coupling partners.
Des Outils pour de Nouvelles Perspectives en Electrochimie Analytique (2015)

National audience
Constraints for symmetry breaking in graph representation (2018)

Many complex combinatorial problems arising from a range of scientific applications (such as computer networks, mathematical chemistry and bioinformatics) involve searching for an undirected graph satisfying a given property. Since for any possible solution there can be a large number of isomorphic representations, these problems can quickly become intractable. One way to mitigate this problem is to eliminate as many isomorphic copies as possible by breaking symmetry during search - i.e. by introducing constraints that ensure that at least one representative graph is generated for each equivalence class, but not the entire class. The goal is to generate as few members of each class as possible - ideally exactly one: the symmetry break is said to be complete in this case. In this paper we introduce novel, effective and compact, symmetry breaking constraints for undirected graph search. While incomplete, these prove highly beneficial in pruning the search for a graph. We illustrate the application of symmetry breaking in graph representation to resolve several open instances in extremal graph theory. We also illustrate the application of our approach to graph edge coloring problems which exhibit additional symmetries due to the fact that the colors of the edges in any solution can be permuted.
A Multiple Insertion/Deletion Correcting Code for Run-Length Limited Sequences (2012)

A code construction is proposed to add a multiple insertion/deletion error correcting capability to a run-length limited sequence. The codewords of this code are themselves run-length limited. The insertion/deletion correcting capability is achieved by requiring several weighted sums of run-lengths in the codewords to satisfy certain congruences modulo primes. The construction is similar to the number-theoretic code proposed by Dolecek and Anantharam, which can correct multiple repetition errors or, equivalently, multiple insertions of zeros. It is shown that if the codewords in this code are run-length limited, then the code is capable of correcting both insertions and deletions of zeros and ones. An algorithm is proposed for decoding over a multiple insertion/deletion channel. Following the work of Dolecek and Anantharam, a systematic encoding method is also proposed for the codes. Furthermore, it is shown that the proposed construction has a higher rate asymptotically than the Helberg code, which is unconstrained in terms of run-lengths, even though our construction has the additional run-length constraints. The need for run-length limited codes that can correct insertion/deletion errors is motivated by bit-patterned media for magnetic recording.
Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease (2020)

Autophagy refers to the degradation of cytoplasmic constituents by a lysosomal-mediated pathway, which plays a critical role in maintaining cellular homeostasis. Importantly, dysregulation of autophagy has been implicated in multiple neurodegenerative disorders. Previous studies reported that autophagy affects the processing of amyloid precursor protein (APP), thus stimulating &amp;beta;‐amyloid (A&amp;beta;) production in Alzheimer&amp;rsquo;s disease (AD) eventually. Although the mechanism of autophagy modulation on APP processing and its pathogenesis has not yet been fully elucidated at the molecular level, but modulation of autophagy has received considerable attention as a promising approach for the treatment of AD. In the early stage of AD, A&amp;beta; may prompt autophagy to facilitate its removal via mTOR‐independent as well as-dependent pathways. However, a recent study proposed that autophagy processes are not properly regulated as AD continues to progress, and consequently, the production of A&amp;beta; tends to accumulate rapidly. Meanwhile, a number of autophagy-related genes (Atg) as well as APP genes are also thought to influence the development of AD, which may serve as a bi‐directional link to autophagy and AD pathology. In this review, we summarized current observations related to autophagy regulation and APP processing, focusing on their dynamic modifications associated with the progression of AD. Recent findings together highlight the essential role of autophagy in the removal and clearance of APP and A&amp;beta; deposition in the pathological condition of AD.
Redistribution of GABAB(1)Protein and Atypical GABABResponses in GABAB(2)-Deficient Mice (2004)

GABAB receptors mediate slow synaptic inhibition in the nervous system. In transfected cells, functional GABAB receptors are usually only observed after coexpression of GABAB(1) and GABAB(2) subunits, which established the concept of heteromerization for G-protein-coupled receptors. In the heteromeric receptor, GABAB(1) is responsible for binding of GABA, whereas GABAB(2) is necessary for surface trafficking and G-protein coupling. Consistent with these in vitro observations, the GABAB(1) subunit is also essential for all GABAB signaling in vivo. Mice lacking the GABAB(1) subunit do not exhibit detectable electrophysiological, biochemical, or behavioral responses to GABAB agonists. However, GABAB(1) exhibits a broader cellular expression pattern than GABAB(2), suggesting that GABAB(1) could be functional in the absence of GABAB(2). We now generated GABAB(2)-deficient mice to analyze whether GABAB(1) has the potential to signal without GABAB(2) in neurons. We show that GABAB(2)-/- mice suffer from spontaneous seizures, hyperalgesia, hyperlocomotor activity, and severe memory impairment, analogous to GABAB(1)-/- mice. This clearly demonstrates that the lack of heteromeric GABAB(1,2) receptors underlies these phenotypes. To our surprise and in contrast to GABAB(1)-/- mice, we still detect atypical electrophysiological GABAB responses in hippocampal slices of GABAB(2)-/- mice. Furthermore, in the absence of GABAB(2), the GABAB(1) protein relocates from distal neuronal sites to the soma and proximal dendrites. Our data suggest that association of GABAB(2) with GABAB(1) is essential for receptor localization in distal processes but is not absolutely necessary for signaling. It is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB(2) subunits.