gebhart/patrepeval huggingface dataset:
Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease (2020)

The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation. Unfortunately, hepatocytes cannot be expanded in vitro, and allogenic cell transplantation requires long-term immunosuppression. Organoid-derived adult liver stem cells can be cultured indefinitely to create sufficient cell numbers for transplantation, and they are amenable to gene correction. This study provides preclinical proof of concept of the potential of cell transplantation in a large animal model of inherited copper toxicosis, such as Wilson's disease, a Mendelian disorder that causes toxic copper accumulation in the liver. Hepatic progenitors from five <i>COMMD1</i>-deficient dogs were isolated and cultured using the 3D organoid culture system. After genetic restoration of COMMD1 expression, the organoid-derived hepatocyte-like cells were safely delivered as repeated autologous transplantations via the portal vein. Although engraftment and repopulation percentages were low, the cells survived in the liver for up to two years post-transplantation. The low engraftment was in line with a lack of functional recovery regarding copper excretion. This preclinical study confirms the survival of genetically corrected autologous organoid-derived hepatocyte-like cells in vivo and warrants further optimization of organoid engraftment and functional recovery in a large animal model of human liver disease.
Studies on the desamidation of bovine collagen (1997)

The most important reactive groups in collagen are amino, amido, guanidino, and carboxyl, all of which are present in comparatively large numbers. It is possible to modify amide groups present in the collagen of achilles tendons and hide trimmings by desamidation (DAM). DAM causes progressive hydrolysis of the amide groups of asparagine and glutamine side chains of collagen, thereby resulting in the reduction of the amide content of collagen. Loss of amide brings about an increase in the number of free carboxyl groups in the desamidated collagen, shown by reduction in its isoionic pH. The new modified collagen, like type I bovine collagen, has high viscosity and high hydroxyproline content. The fibril formation of the modified collagen showed slight variation, and polyacrylamide gel electrophoretic analysis indicated largely alpha components, indicating destruction of inter- and intramolecular crosslinks. The swelling behavior of the modified collagen is significantly higher compared to type I bovine collagen.
Integrated Inverse Class-F Silicon Power Amplifiers for High Power Efficiency at Microwave and mm-Wave (2016)

This paper presents two 2-stage inverse class-F power amplifiers (PAs) at 24 GHz and 38 GHz, integrated in 0.13 μm SiGe BiCMOS technology. The PAs are composed of an inverse class-F output stage proceeded by a class-AB driving amplifier. An inter-stage matching network between the driver and output stage delivers an optimal inter-stage power to the output stage with a maximum PAE in the driver amplifier. The output stage's load network based on multi-resonance LC resonators terminates harmonic impedance explicitly up to the third of the fundamental signal. By leveraging a native low capacitive reactance, the class-F <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> load network shapes a quasi-rectangular current waveform that effectively contains up to the fifth harmonic spectral component. A high impedance control is limited up to the second harmonic, shaping a half-sinusoid voltage peaking induced by DC, fundamental, and the second harmonic voltage spectra. The 24 GHz PA achieves 50% peak PAE, 16 dBm OP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1dB</sub> , 18 dBm P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> , and 19 dB saturated power gain with 2.3 V supply voltage at 24 GHz. The 24 GHz PA can maintain >45% PAE over 23.5-25.5 GHz and 1.5-2.4 V supply voltage range, manifesting a PAE robustness to the frequency and supply variations. For 38 GHz PA, measurements show 38.5% peak PAE, 15 dBm OP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1dB</sub> , 17 dBm P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> with 15 dB of saturated power gain at the OP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1dB</sub> point when 2.4 V supply voltage is applied. The 38 GHz PA can sustain >35% PAE over 36-39 GHz and 1.5-2.5 V supply variation. The PAs also are tested under the input of band-limited signals modulated by various modulation schemes including 8-PSK, QAM, 16-QAM, 64-QAM, and 128QAM, and test results are presented in this paper. The chip size is 0.95 × 0.6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for 24 GHz PA and 0.93 × 0.55 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for 38 GHz PA, including all pads.
A Tractable Model of Pair Density Wave (2023)

The paper describes a simple mechanism for superconducting pairing with finite wave vector (Pair Density Wave) which is illustrated with a quasi one-dimensional model. Within this model pair and charge density wave order parameters are intertwined emerging as components of the same matrix field and are related by particle-hole symmetry. Experimental applications are discussed.
Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins (2008)

Abstract. Here we develop a multi-template analysis for tensor-based morphometry (TBM) which aims to reduce error from the registration step. In conventional TBM, a single template is nonlinearly registered to all images in the study, and the deformation field statistics are computed from the transformations. Using an MRI dataset from 23 monozygotic and 23 dizygotic twin pairs, we instead registered each individual twin image to 9 additional brain templates using a Riemannian fluid algorithm [3]. Average deformation tensors from multiple registrations were computed within each image, using a log-Euclidean framework [1]. To quantify improvements as the number of registration templates increased from 1 to 9, sequential t-tests assessed the significance of any error reduction, as each new template was added. For each number of templates, we also computed two tensor-derived metrics, and maps of the intraclass correlation of local volume differences, to evaluate any power advantages of multi-atlas TBM. 1
Sur la théorie de la photographie des couleurs simples et composées par la méthode interférentielle (1894)

Pas de Résumé disponible
<title>Extraction of moving objects for content-based video coding</title> (1998)

This paper considers video object plane (VOP) segmentation for the content-based video coding standard MPEG-4. To provide multimedia applications with new functionalities, such as content-based interactivity and scalability, the new video coding standard MPEG-4 relies on a content-based representation. To take advantage of these functionalities, a prior decomposition of sequences into semantically meaningful, physical objects is required. We formulate this problem as one of separating foreground objects from the background based on motion information. For the object of interest, a two- dimensional binary model is derived and tracked throughout the sequence. The model points consist of edge pixels detected by the Canny operator. To accommodate rotation and changes in shape of the tracked object, the model is updated every frame. These binary models then guide the actual VOP extraction. Due to the excellent edge localization properties of the Canny operator, the resulting VOP contours are very accurate. Both the model initialization and update stage exploit motion information. The main assumption underlying our approach is the existence of a dominant global motion that can be assigned to the background. Areas that do not follow this background motion indicate the presence of independently moving physical objects. Two methods to identify such objects are presented. The first one employs a morphological motion filter with a new filtering criterion that measures the deviation of the locally estimated optical flow from the corresponding global motion. The second method computes a change detection mask by taking the difference between consecutive frames. The first version is more suitable for sequences involving little motion, whereas the second version is stronger at dealing with fast moving objects.
Sequence of two new HLA‐Cw alleles: HLA‐Cw*0313 and HLA‐Cw*1208 (2002)

Two new HLA-C alleles have been identified by reverse line blot assay and direct sequencing of polymerase chain reaction (PCR) products. The first polymorphism encodes an amino acid change from lysine in Cw*12022 to asparagine in Cw*1208 at residue 66. The second polymorphism encodes two amino acid changes from isoleucine in Cw*03031 to threonine in Cw*0313 at residue 93 and isoleucine to leucine at residue 94. The functional significance of these polymorphisms on peptide-binding and/or T-cell recognition is unknown.
Fusion of human cells with carrot protoplasts induced by polyethylene glycol (2009)

HeLa cells were fused with protoplasts of carrot (Daucus carota) by the use of polyethylene glycol as fusion agent. The two types of nuclei can be recognized in the heterokaryon by their differential staining ability and by the tritium labelling of HeLa cells. Seventy-two hours after fusion the cells appeared surrounded by cell walls and in some cases contained HeLa and carrot fused interphase nuclei. The percentage of fusion is estimated to be approximately 0.3 to 0.6%.
Neonatal Airway Obstruction (2013)

Airway obstruction is one of the most common life-threatening conditions among newborns and presents a diagnostic and therapeutic challenge to the neonatologist. Successfully distinguishing between the many potential airway lesions will lead to a more rapid and efficient evaluation and enhance patient outcomes. This review addresses each anatomic level of potential upper airway compromise, highlighting appropriate studies to determine the diagnosis and outline the necessary treatments.
Delta-Radiomics Signature For Prediction Of Survival In Advanced Nsclc Patients Treated With Immunotherapy (2021)

with an approximate 5-years survival rate of 13% from diagnosis. The potential of computational image analysis to provide decision support in oncology and the importance of identifying predictive and non-invasive biomarkers of disease progression and response to therapy has led to Radiomics. The objective of this study was to develop a delta-radiomics signature to predict survival and treatment response in patients with advanced non-small cell lung cancer (NSCLC) undergoing immunotherapy. Pre-treatment and first follow-up CT images and intra-nodular and peri-nodular regions from 88 patients have been used to calculate delta-features. The deltaradiomics signature significantly stratified highand low-risk patients (p = 0.018), it was significantly associated with Overall Survival (p = 0.03) and it predicted responders with an area under the receiver operating characteristic curve (ROC-AUC) of 0.76 in an independent test set. The results demonstrate the potential of delta-radiomics to be an early biomarker of immunotherapy response.
Topical Co-Delivery Of Indomethacin And Nigella Sativa L. Essential Oil In Poly--Caprolactone Nanoparticles: In Vivo Study Of Anti-Inflammatory Activity. (2018)

Indomethacin is a potent, nonselective Non-steroidal Anti-inflammatory Drug (NSAID) but its low water-solubility precludes its use as topical dosage form. As with other NSAIDs, the systemic delivery is associated with high risk of serious gastrointestinal adverse events including bleeding, ulceration and perforation of stomach and intestines. Here we demonstrate a safer way of administration i.e via topical demonstrating synergistic effects when co-delivered with Nigella sativa L. seeds essential oil (NSSEO) in the form of co-encapsulated particles (~200 nm) of poly--caprolactone. The particles showed penetrability across stratum corneum to dermis layer in ex-vivo human skin. Further study in the xyline-induced ear edema in mice was performed, and co-encapsulated particles demonstrated highest anti-inflammatory effect compared to indomethacin particles and indomethacin gels. Despite slower onset compared to indomethacin gels, the inflamed ear continued to show reduction in thickness over 8 hours of observation demonstrating synergistic and pro-longed effect contributed by NSSEO. In immunohistochemistry study of CD45+, the mice ears treated with co-encapsulated particles showed considerable reduction in lesions, epidermal-dermal separation and inflamma?tory cells (lymphocytes and neutrophils) infiltration as compared to other formulation. Based on microscopic evaluation, the anti-inflammatory inhibition effect of co-encapsulated particles is the highest (90%) followed by indomethacin particles (79%) and indomethacin gel (49%). The findings suggest not only skin permeability of indomethacin significantly improved but also the therapeutic effects, all provided by the presence of NSSEO in the particles. This study paves the way to more co-encapsulation of any other contemporary medicines in combination with this wholesome natural oil, NSSEO.
Molecular organization via ionic interactions at interfaces. 1. Monolayers and LB films of cyclic bisbipyridinium tetracations and dimyristoylphosphatidic acid (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular organization via ionic interactions at interfaces. 1. Monolayers and LB films of cyclic bisbipyridinium tetracations and dimyristoylphosphatidic acidRamesh C. Ahuja, Pier Lorenzo Caruso, Dietmar Moebius, Gerald Wildburg, Helmut Ringsdorf, Douglas Philp, J. F. Stoddart, and Jon A. PreeceCite this: Langmuir 1993, 9, 6, 1534–1544Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/la00030a019https://doi.org/10.1021/la00030a019research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase. (1979)

The isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase from Pseudomonas (ATCC 29574) are described. The dehydrogenase component abstracts electrons from the substrate and transfers them to oxidation-reduction dyes such as potassium ferricyanide and 2,6-dichlorophenolindophenol but not to molecular oxygen. It is composed of a single polypeptide chain with a molecular weight of 72,000 and exhibits the absorption spectrum of a reduced b-type cytochrome with maxima at 563, 532, 433, 323, and 278 nm. The oxidase component transfers electrons, derived from the former component, to oxygen, and has a molecular weight of 48,000. The absorption spectrum exhibits broad peaks at 680, 438, and 358 nm, and a peak at 280 nm. On sucrose gradient centrifugation and polyacrylamide gel electrophoresis, these two components are shown to form a molecular complex, which has the reconstituted oxidase activity. The turnover number of the reconstituted enzyme is comparable to that of the native enzyme.
August consultation #7 (2008)

Journal of Cataract & Refractive Surgery: August 2008 - Volume 34 - Issue 8 - p 1235-1237 doi: 10.1016/j.jcrs.2008.06.008
An Efficient Self-Service Pre-Payment Courier System on Mobile NFC Technology (2015)

The business and payment can be achieved not only using real money but also virtual one. With the rapid development of e-commerce, the virtual one will be more convenient for transaction. Therefore, an SSPP (Self-Service Pre-Payment) courier system is presented, which characterizes an innovative, convenient and efficient NFC (Near Field Communication) pre-payment system based on card simulation mode. The pre-payment process concerning virtual currency has been supported through a simple NFC device, which operates in RF (Radio Frequency) band. It ensures the micro-payment services of mobile to POS can be achieved. In this paper, an efficient scheme is described to check its feasibility, and some experimental results have also been given to verify that this system is candidate for the future express industry.
Optimization of dual-mixer time-difference multiplier (2004)

The dual-mixer time-difference (DMTD) multiplication technique used in frequency stability measurement of precision frequency sources shows potential for achieving a frequency stability measurement floor as low as a few parts in 10 15 at 1 s in terms of Allan deviation (ADEV) at 5 MHz at ambient temperature. The paper discusses the optimization of the DMTD multiplier using the frequency stability floor as a criterion for its efficiency. The instability sources of concern are all the noise sources as well as non linear effects and deterministic effects, such as phase noise in the common oscillator, noise in the mixers and amplifiers, intermodulation products including the power-line pickup, electrical asymmetry (impairs the common-mode rejection of the phase and amplitude variations), phase dependence on environmental fluctuations, disturbing electromagnetic fields, and inappropriate construction (connectors, cabling, shielding, grounding). The optimization is demonstrated on the second version of DMTD multiplier designed at the Institute of Radio Engineering and Electronics (IREE). The IREE system has the classical DMTD structure, i.e. with a time-interval counter measuring the time difference between the zero crossings of the two beat-note signals. The modular construction allows modifications of the DMTD critical elements. The common oscillator as well as the time-interval counter are located outside the mixer-amplifier unit. The system can be operated at 5 and 10 MHz with the beat frequencies of 5 and 10 Hz, respectively, giving the multiplication factor of 10 6 . The frequency stability measurement floor achieved through the optimization shows ADEV(tau = 1 s) = 6.9times10 -15 at 5 MHz. At the basic sampling interval, tau 0 = 0.2 s, the time deviation TDEV is 3.5 fs with the TDEV floor of 2 fs. This outstanding performance makes it possible to measure the frequency stability of future 5MHz quartz crystal oscillators of a f
Autoradiographic Analyses of the Effects of Adrenalectomy and Corticosterone on 5-HT<sub>1A</sub> and 5-HT<sub>1B</sub> Receptors in the Dorsal Hippocampus and Cortex of the Rat (1992)

Quantitative autoradiography was used to evaluate the effects of adrenalectomy (ADX) and corticosterone (CORT) on binding at 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. ADX increased binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin at 5-HT1A receptors in the oriens and lacunosum moleculare layers of CA2 and CA3, in the lacunosum moleculare layer of CA4 region, and in the dentate gyrus. In restraint-stressed ADX rats, binding was increased only in the oriens and lacunosum moleculare layers of CA2. Restoration of baseline levels of CORT reversed the effects of ADX on 5-HT1A receptors in the hippocampus, while high levels of CORT decreased binding at 5-HT1A receptors in the dentate gyrus. No treatment affected binding at 5-HT1A receptors in the CA1 region of the hippocampus or in the cortex. ADX increased binding of [125I]iodocyanopindolol at 5-HT1B receptors in the infrapyramidal dentate, but this effect was not observed in ADX rats that were restrained. CORT treatment in both ADX and SHAM (adrenally intact) rats resulted in binding at 5-HT1B receptors that was lower than that in untreated ADX and SHAM rats in the infrapyramidal dentate, and lower than that in ADX rats in the suprapyramidal dentate and CA4. In ADX and SHAM rats, CORT also reduced binding at 5-HT1B receptors in area 2 of the cortex. It is suggested that decreases in binding at 5-HT1A and 5-HT1B/1D receptors resulting from chronic exposure to high levels of CORT may also occur in animals that fail to adapt to chronic severe stress. Such changes in binding may play important roles in the etiology of depression.
Robust single stage detector based on two-stage regression for SAR ship detection (2018)

Automatic ship detection in SAR imagery plays an indispensable role in the surveillance of maritime activity. With the spring of the deep neural network and the rapid development of SAR imaging technique, SAR ship detection based on deep convolutional neural networks has attracted increasing attention in remote sensing imagery interpretation. However, the ships of variant sizes (multi-scale) and complicated background result in the essential challenge of using deep learning based methods. The initial motivation of this paper is to design a structure that can achieve better accuracy as well as maintain compatible time efficiency on small object detection. Aiming at solving this problem, we develop anelaborately designed network based on single-shot detector and two-stage regression called Robust two-stage regression network (R2RN). Our network comprises an anchor modified first module and an object detection second module as well as the connective block between them which inherits the essence of feature pyramid. Experiments on SAR ship dataset have demonstrated the effectiveness and efficiency of the proposed method.
Adjustable impact-time-control guidance law against non-maneuvering target under limited field of view (2021)

This article proposes an impact-time-control guidance law that can keep a non-maneuvering moving target in the seeker’s field of view (FOV). For a moving target, the missile calculates a predicted intercept point (PIP), designates the PIP as a new virtual stationary target, and flies to the PIP at the desired impact time. The main contribution of the article is that the guidance law is designed to always lock onto the moving target by adjusting the guidance gain. The guidance law for the purpose is based on the backstepping control technique and designed to regulate the defined impact time error. In this procedure, the desired look angle, which is a virtual control, is designed not to violate the FOV limit, and the actual look angle of the missile is kept within the FOV by tracking the desired look angle. To validate the performance of the guidance law, numerical simulation is conducted with different impact times. The result shows that the proposed guidance law intercepts the moving target at the desired impact time maintaining the target lock-on condition.