gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of Chiral Palladium(II) Complexes Containing a Pd-C*(sp3) .sigma.-Bond (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of Chiral Palladium(II) Complexes Containing a Pd-C*(sp3) .sigma.-BondAkio Yoneda, Tadao Hakushi, G. R. Newkome, and Frank R. FronczekCite this: Organometallics 1994, 13, 12, 4912–4918Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/om00024a038https://doi.org/10.1021/om00024a038research-articleACS PublicationsRequest reuse permissionsArticle Views275Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Reduction of four-wave mixing crosstalk in WDM systems using unequally spaced channels (1994)

Crosstalk due to four-wave mixing (FWM) is the dominant nonlinear effect in long-haul multichannel optical communication systems employing dispersion-shifted fiber. A technique to design the channel frequency allocation in order to minimize the crosstalk due to FWM is presented. It is shown that suitable unequal channel separations can be found for which no four-wave mixing product term is superimposed on any of the transmitted channels. This is obtained at the expense of some expansion of the system bandwidth. Simulations are presented to show the effectiveness of this technique in a 10-channel, 10-Gb/s per channel, system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Arsenite oxidase in complex with antimonite and arsenite oxyanions: Insights into the catalytic mechanism (2023)

Arsenic contamination of groundwater is among one of the biggest health threats affecting millions of people in the world. There is an urgent need for efficient arsenic biosensors where the use of arsenic metabolizing enzymes can be explored. In this work, we have solved four crystal structures of arsenite oxidase (Aio) in complex with arsenic and antimony oxyanions and the structures determined correspond to intermediate states of the enzymatic mechanism. These structural data were complemented with density-functional theory calculations providing a unique view of the molybdenum active site at different time points that, together with mutagenesis data, enabled to clarify the enzymatic mechanism and the molecular determinants for the oxidation of As(III) to the less toxic As(V) species.
Optofluidic droplet router (2014)

Abstract This contribution presents an optofluidic droplet router which is able to route and steer microdroplets using optically induced forces created solely by the bulk photovoltaic effect on a nonlinear substrate. The combination of microfluidic tools with the properties of a photorefractive crystal allows for the generation of dielectrophoretic forces that can be either repulsive, leading to virtual barriers , or attractive, creating virtual rails . The sign of these forces is solely determined by the electrical properties of the liquid medium under investigation. Moreover, the induced structures on the bottom of the microfluidic channel are optically reconfigurable, so that the same device can easily be adopted for different purposes. Appropriate droplet‐generating devices are fabricated by UV illumination of SU‐8 and polydimethylsiloxane replica molding of the master structures. The bottom of the channels is formed by an iron‐doped lithium niobate crystal, whose internal electric fields are induced by structured illumination patterns and exert dielectrophoretic forces on droplets in the microfluidic section. image
A dual-bit split-gate EEPROM (DSG) cell in contactless array for single-Vcc high density flash memories (2002)

A new source-side injection Dual-bit Split-Gate (DSG) flash EEPROM cell is designed and characterized. With a 0.6 /spl mu/m process, the cell-size of 1.95 /spl mu/m/sup /spl and//2 per bit in a contactless array is achieved. With a shared select-gate, the cell consists of three directly jointed channels. Taking advantage of the split-gate structure, the threshold voltage of the floating-gate transistor is allowed to move from enhancement-mode to depletion-mode between write and erase operations. Only moderate voltages (less than 10 V) are required the for the cell operations, which relax the high-voltage device requirements on peripheral circuitry and thus simplify the process with less masking steps. With on-chip charge pumps, this cell is suitable for very high density and low power mass-storage applications with single-Vcc power supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of 2-Hydroxypropyl-β-cyclodextrin on Percutaneous Absorption of Methyl Paraben (1995)

A potential use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) to solubilize methyl paraben and to suppress its percutaneous absorption was examined, and compared with nonionic surfactant HCO-60. HP-beta-CyD significantly increased the solubility of methyl paraben in water, where the apparent 1:1 stability constant of the soluble complex was determined to be 2150 M-1. The in-vitro cutaneous permeability of methyl paraben through an isolated skin of hairless mouse was suppressed by HP-beta-CyD, thus promoting the bioconversion of methyl paraben to the less toxic metabolite, p-hydroxybenzoic acid (p-HBA) in the epidermis. These effects of HP-beta-CyD were greater than those of HCO-60. HP-beta-CyD (2% w/v) reduced the in-vivo percutaneous absorption of methyl paraben by 66% 24 h after the topical application of a solution containing [14C]methyl paraben to hairless mouse skin. Additionally, the percutaneous absorption of [14C]HP-beta-CyD was confirmed to be extremely low. These results suggest that HP-beta-CyD is useful in liquid preparations of methyl paraben for topical application.
Arthroscopic Rotator Cuff Repair: Establishing the Footprint (2005)

Arthroscopic rotator cuff repair has gained much momentum and acceptance over the past decade due to the excellent patient outcomes and diminished patient morbidity. The optimal technique and repair construct continues to be a subject of much interest and debate. This article will explore the subject of footprint restoration and describe our technique for maximizing the footprint coverage in rotator cuff repairs.
Abstract 122: Surgical Angiogenesis To Nerve Allografts Improves Early Functional Recovery In A Rat Sciatic Nerve Defect Model (2020)

Purpose: It is widely accepted that functional results are poor when nerve grafts are transplanted in severely scarred tissue beds and that independent blood supply of nerve grafts could improve outcomes. Optimized processed allografts (OPA) have no vascular supply. Addition of vascularization to the OPA promotes immediate revascularization and minimizes the period of ischemia, diminishing fibrosis and central necrosis potentially enhancing functional recovery. The purpose of this study was to determine how addition of vascularization to nerve allografts would affect functional recovery. Methods: Sixty Lewis rats were divided into three groups of 20 animals each. Nerves harvested from Sprague Dawley rats were decellularized according to protocol (Hundepool et al, 2017), irradiated and stored until use as OPA. Unilateral 10 mm sciatic nerve defects were repaired with (i) OPA, (ii) OPA wrapped with a superficial inferior epigastric fascial (SIEF) flap to provide vascularization to the nerve bed, and (iii) autografts. Twelve and 16 weeks after surgery, nerve regeneration was assessed using functional, electrophysiologic, histomorphologic, and immunofluorescence analyses (N=10/time point). Ultrasound was used during the survival period to noninvasively evaluate muscle atrophy. Results: Rats in which a well-vascularized SIEF flap was provided to the nerve allograft showed significantly better isometric tetanic force (ITF) recovery at 12 weeks, compared to allograft alone. ITF recovery normalized between groups at 16 weeks. Ultrasound showed a trend toward less atrophy in SIEF rats, compared to allograft only, however, this was not significant. Electrophysiology showed superiority of autografts at both time points. Histomorphometric analysis revealed no differences between groups with regard to axon area, axon count and myelin area, however, the N-ratio was significantly inferior in allografts at 12 weeks compared the autograft and SIEF group. Using immunofluorescence, the expression of CD34, indicating vascularity, showed significantly improved levels in SIEF samples compared to allografts at 12 weeks, and highest expression at 16 weeks compared to all groups. Protein gene product 9.5 (PGP9.5), a pan-neuronal marker, did not reveal any differences between groups at 12 or 16 weeks. Conclusion: This study suggests that addition of a well-vascularized fascial flap to the nerve allograft bed increases vascularity in the nerve allograft, subsequently improving early functional recovery, comparable to autografts.
Genetic manipulation by means of microcell-mediated transfer of normal human chromosomes into recipient mouse cells. (1980)

Microcell-mediated chromosome transfer is an innovative approach to the production of karyotypically simple hybrids. This method of gene transfer, employing micronuclei formed by prolonged Colcemid treatment, has been utilized for rodent systems. Expansion of this technology to include transfer of normal human genetic material has been hindered because large micronucleate populations from diploid human cells have been unobtainable. This report describes the production of micronuclei in 40-60% of normal human fibroblasts. These micronucleated cells have been enucleated by combining centrifugation and cytochalasin B treatment, and the resultant microcells have been purified and fused to recipient mouse (LMTK-) cells. Microcell hybrid clones containing a single human chromosome have been isolated from three separate fusion experiments. The time course for production of these hybrids, from fusion to karyotypic analysis, was 6 weeks. With a transfer frequency of about 2 x 10(-6), a single intact human chromosome has become a functioning element of the murine genome.
Compensation of physiological motion enables high-yield whole-cell recording in vivo (2020)

1.1.1 Abstract Whole-cell patch-clamp recording in vivo is the gold-standard method for measuring subthreshold electrophysiology from single cells during behavioural tasks, sensory stimulations, and optogenetic manipulation. However, these recordings require a tight, gigaohm resistance, seal between a glass pipette electrode’s aperture and a cell’s membrane. These seals are difficult to form, especially in vivo, in part because of a strong dependence on the distance between the pipette aperture and cell membrane. We elucidate and utilize this dependency to develop an autonomous method for placement and synchronization of pipette’s tip aperture to the membrane of a nearby, moving neuron, which enables high-yield seal formation and subsequent recordings in the deep in the brain of the living mouse, in the thalamus. This synchronization procedure nearly doubles the reported gigaseal yield in the thalamus (&gt;3 mm below the pial surface) from 26% (n=17/64) to 48% (n=32/66). Whole-cell recording yield improved from 10% (n = 9/88) to 24% (n=18/76) when motion compensation was used during the gigaseal formation. As an example of its application, we utilized this system to investigate the role of the sensory environment and ventral posterior medial region (VPM) projection synchrony on intracellular dynamics in the barrel cortex. This method results in substantially greater subcortical whole-cell recording yield than previously reported and thus makes pan-brain whole-cell electrophysiology practical in the living mouse brain.
An Asymmetric Synthesis of Lactones from Cyclic Acid Anhydrides with Chiral Binaphthyldiamines (1986)

Journal Article An Asymmetric Synthesis of Lactones from Cyclic Acid Anhydrides with Chiral Binaphthyldiamines Get access Yukio Kawakami, Yukio Kawakami Institute for Chemical Research, Kyoto University, Uji. Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Jun Hiratake, Jun Hiratake Institute for Chemical Research, Kyoto University, Uji. Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Yukio Yamamoto, Yukio Yamamoto Institute for Chemical Research, Kyoto University, Uji. Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Jun’ichi Oda Jun’ichi Oda Institute for Chemical Research, Kyoto University, Uji. Kyoto 611, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 3, 1 March 1986, Pages 693–698, https://doi.org/10.1080/00021369.1986.10867431 Published: 01 March 1986 Article history Received: 25 September 1985 Published: 01 March 1986
LiDAR-Based 3D Scans of Soil Surfaces and Furrows in Two Soil Types (2019)

Soil surface measurements play an important role in the performance assessment of tillage operations and are relevant in both academic and industrial settings. Manual soil surface measurements are time-consuming and laborious, which often limits the amount of data collected. An experiment was conducted to compare two approaches for measuring and analysing the cross-sectional area and geometry of a furrow after a trailing shoe sweep. The compared approaches in this study were a manual pinboard and a Light Detection and Ranging (LiDAR) sensor. The experiments were conducted in coarse sand and loamy sand soil bins exposed to three levels of irrigation. Using the LiDAR, a system for generating 3D scans of the soil surface was obtained and a mean furrow geometry was introduced to study the geometrical variations along the furrows. A comparison of the cross-sectional area measurements by the pinboard and the LiDAR showed up to 41% difference between the two methods. The relation between irrigation and the resulting furrow area of a trailing shoe sweep was investigated using the LiDAR measurements. The furrow cross-sectional area increased by 11% and 34% under 20 mm and 40 mm irrigation compared to non-irrigated in the coarse sand experiment. In the loamy sand, the cross-sectional area increased by 17% and 15% by irrigation of 20 mm and 40 mm compared to non-irrigated measured using the LiDAR.
Double correlating interferometer scheme for measuring PM and AM noise (1998)

A new scheme is proposed to measure close-to-carrier PM and AM noise by means of correlation between two interferometric measurements. The most relevant feature is the ability to reject interferometric system noise, thus improving the sensitivity. Implementation and experimental results are discussed.
Effects of laser shock processing on the fatigue crack growth rates of 2024-T62 aluminum alloy (1998)

Laser Shock Processing (LSP) is a new technique for strengthening the metals. This paper investigates the effects of LSP on the fatigue crack growth (FCG) behavior of 2024-T62 aluminum alloy. The FCG tests results show that the fatigue crack growth rates (FCGRs) at a given stress intensity have been reduced by over one order of magnitude.
Transport layer identification of P2P traffic (2004)

Since the emergence of peer-to-peer (P2P) networking in the late '90s, P2P applications have multiplied, evolved and established themselves as the leading `growth app' of Internet traffic workload. In contrast to first-generation P2P networks which used well-defined port numbers, current P2P applications have the ability to disguise their existence through the use of arbitrary ports. As a result, reliable estimates of P2P traffic require examination of packet payload, a methodological landmine from legal, privacy, technical, logistic, and fiscal perspectives. Indeed, access to user payload is often rendered impossible by one of these factors, inhibiting trustworthy estimation of P2P traffic growth and dynamics. In this paper, we develop a systematic methodology to identify P2P flows at the transport layer, i.e., based on connection patterns of P2P networks, and without relying on packet payload. We believe our approach is the first method for characterizing P2P traffic using only knowledge of network dynamics rather than any user payload. To evaluate our methodology, we also develop a payload technique for P2P traffic identification, by reverse engineering and analyzing the nine most popular P2P protocols, and demonstrate its efficacy with the discovery of P2P protocols in our traces that were previously unknown to us. Finally, our results indicate that P2P traffic continues to grow unabatedly, contrary to reports in the popular media.
Novel Quantitative Methods for the Determination of Biomaterial Cytotoxicity (1992)

Two novel methods for the determination of biomaterial cytotoxicity using cell culture are presented. The methods combine a standardized protocol for producing extracts from medical devices with either the established MTT assay or a new fluorimetric assay. The suitability of both methods for evaluating the toxicity of candidate materials was demonstrated by resolution of the differences in the toxic effects of serial dilutions of a PVC extract on BHK21 and HT1080 cells. The tests yield highly reproducible, quantitative results and can be applied to materials in the usual physical forms applicable to artificial organs.
Supplementary Figure 1 from Autoantibodies Drive Heart Damage Caused by Concomitant Radiation and PD-1 Blockade (2023)

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Surface modification of carbon nanotubes with dendrimers or hyperbranched polymers (2011)

The different methods for modification of carbon nanotubes with dendrimers or hyperbranched polymers are summarized, and recent development is highlighted by discussing some representative examples in detail.
Mechanical Bond-Induced Radical Stabilization (2012)

A homologous series of [2]rotaxanes, in which cyclobis(paraquat-p-phenylene) (CBPQT(4+)) serves as the ring component, while the dumbbell components all contain single 4,4'-bipyridinium (BIPY(2+)) units centrally located in the midst of oligomethylene chains of varying lengths, have been synthesized by taking advantage of radical templation and copper-free azide-alkyne 1,3-dipolar cycloadditions in the formation of their stoppers. Cyclic voltammetry, UV/vis spectroscopy, and mass spectrometry reveal that the BIPY(•+) radical cations in this series of [2]rotaxanes are stabilized against oxidation, both electrochemically and by atmospheric oxygen. The enforced proximity between the BIPY(2+) units in the ring and dumbbell components gives rise to enhanced Coulombic repulsion, destabilizing the ground-state co-conformations of the fully oxidized forms of these [2]rotaxanes. The smallest [2]rotaxane, with only three methylene groups on each side of its dumbbell component, is found to exist under ambient conditions in a monoradical state, a situation which does not persist in acetonitrile solution, at least in the case of its longer analogues. (1)H NMR spectroscopy reveals that the activation energy barriers to the shuttling of the CBPQT(4+) rings over the BIPY(2+) units in the dumbbells increase linearly with increasing oligomethylene chain lengths across the series of [2]rotaxanes. These findings provide a new way of producing highly stabilized BIPY(•+) radical cations and open up more opportunities to use stable organic radicals as building blocks for the construction of paramagnetic materials and conductive molecular electronic devices.
New Principles in Medicinal Organometallic Chemistry (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dopamine signaling: target in glioblastoma (2014)

Despite numerous promising discoveries in contemporary cancer research, and the emerging innovative cancer treatment strategies, the global burden of malignant diseases is expected to rise, in part due to the rapidly aging human populations. Consequently, there is an urgent need to design and validate new treatments in oncology, especially for cancer types with presently dismal prognosis due to limited treatment options, such as for patients suffering from glioblastoma multiforme. The efforts to address such need rely in large part on the recently introduced powerful technologies including high-throughput screens to uncover genetic and functional vulnerabilities of specific types of human tumors. Such effort also raises hopes to identify molecular targets so far associated with pathologies other than malignancies, and thereby bring about opportunities to repurpose already existing, approved drugs that target such mechanisms. Apart from lower cost of introducing such treatments for oncological diseases, drug repurposing is also good news due to much shorter time needed from target discovery to clinical applications, an aspect particularly valuable in disease contexts such as glioblastoma.
An English grammar checker as a writing aid for students of English as a second language (1997)

No abstract available.
Parallel photonics: based on VCSEL and microphotonics array (2004)

We review the progress of photonic subsystems based upon parallel devices and components such as vertical cavity surface emitting laser and microlens arrays. This concept of ultraparallel formation will become one of key issues in future high speed and wide-band networks as well as large variety of optoelectronics systems.
Hyaluronan and Hyaluronan Binding Proteins Are Normal Components of Mouse Pancreatic Islets and Are Differentially Expressed by Islet Endocrine Cell Types (2012)

The pancreatic islet comprises endocrine, vascular, and neuronal cells. Signaling among these cell types is critical for islet function. The extracellular matrix (ECM) is a key regulator of cell-cell signals, and while some islet ECM components have been identified, much remains unknown regarding its composition. We investigated whether hyaluronan, a common ECM component that may mediate inflammatory events, and molecules that bind hyaluronan such as versican, tumor necrosis factor-stimulated gene 6 (TSG-6), and components of inter-α-trypsin inhibitor (IαI), heavy chains 1 and 2 (ITIH1/ITIH2), and bikunin, are normally produced in the pancreatic islet. Mouse pancreata and isolated islets were obtained for microscopy (with both paraformaldehyde and Carnoy's fixation) and mRNA. Hyaluronan was present predominantly in the peri-islet ECM, and hyaluronan synthase isoforms 1 and 3 were also expressed in islets. Versican was produced in α cells; TSG-6 in α and β cells; bikunin in α, β, and δ cells; and ITIH1/ITIH2 predominantly in β cells. Our findings demonstrate that hyaluronan, versican, TSG-6, and IαI are normal islet components and that different islet endocrine cell types contribute these ECM components. Thus, dysfunction of either α or β cells likely alters islet ECM composition and could thereby further disrupt islet function.