gebhart/patrepeval huggingface dataset:
Neuroprotective Effects of Hydrated Fullerene C60: Cortical and Hippocampal EEG Interplay in an Amyloid-Infused Rat Model of Alzheimer's Disease (2015)

We studied the effects of fullerene C60 nanoparticles, namely hydrated fullerene C60 (C60HyFn), on interrelations between EEG frequency spectra from the frontal cortex and the dorsal hippocampus (CA1) on an amyloid-β (Aβ) rat model of Alzheimer's disease (AD). Infusion of Aβ1-42 protein (1.5 μl) into the CA1 region two weeks before EEG testing diminished hippocampal theta (3.8-8.4 Hz) predominance and eliminated cortical beta (12.9-26.2 Hz) predominance observed in baseline EEG of rats infused with saline (control) or with C60HyFn alone. In contrast, these Aβ1-42 effects were abolished in rats pretreated with C60HyFn, 30 min apart. Dopaminergic mediation in AD has been shown to be involved in neuronal plasticity and Aβ transformation in different ways. To clarify its role in the cortex-hippocampus interplay in the Aβ model of AD, we used peripheral injection of a dopamine agonist, apomorphine (APO), at a low dose (0.1 mg/kg). In rats infused with C60HyFn or Aβ1-42 alone, APO attenuated the cortical beta predominance, with immediate and delayed phases evident in the Aβ1-42-rats. Pretreatment with C60HyFn diminished the APO effect in the Aβ1-42-treated rats. Thus, we show that intrahippocampal injection of Aβ1-42 dramatically disrupts cortical versus hippocampal EEG interrelations and that pretreatment with the fullerene eliminates this abnormality. We suggest that some effects of C60HyFn may be mediated through presynaptic dopamine receptors and that water-soluble C60 fullerenes have a neuroprotective potential.
Design of an IEEE 1149.4 Test Chip with Extended ABM Functionality (2008)

June
Examination of Mid-Infrared Photon Detection by Hot Electron Bolometer With Twin Slot Antenna (2023)

As a high-speed and sensitive mid-infrared (MIR) photon detector, we developed a MIR superconducting hot electron bolometer (MIR-HEB). The MIR-HEB consists of a twin-slot MIR-wavelength antenna and a small Nb/NbN superconducting strip located at the antenna's feeding point. To prevent the HEB from latching, a parallel shunt resistor was added. For detector evaluation, a continuous-wave quantum cascade laser with a wavelength of 4.57 μm was used as the source of MIR light. A constant bias current was applied near the HEB critical current during the detector operation. Upon illumination with MIR light, numerous voltage pulses with a width of approximately 4 ns were observed. Furthermore, it was demonstrated that the pulse count rates were nearly proportional to the incident power over a two-order magnitude range. We conclude that MIR-HEB achieved MIR photon detection based on this result. Also confirmed were the polarization dependences attributed to the antenna's operation.
Charge properties of low density lipoprotein subclasses (1997)

Measurements of electrophoretic mobility and particle size of low density lipoproteins (LDL) allowed use of standard electrokinetic theory to quantitate LDL charge characteristics from subjects with predominance of large LDL (pattern A, n = 9) or small LDL (pattern B, n = 8). Pattern A LDL was found to have significantly lower (P < or = 0.001) mobility (-0.22 +/- 0.01 micron s-1 cm V-1), surface potential (-4.2 +/- 0.3 mV) and charge density (-500 +/- 34 esu/cm2) than pattern B LDL (-0.25 +/- 0.01 micron s-1 cm V-1, -4.9 +/- 0.3 mV, and -580 +/- 30 esu/cm2), but no significant difference in particle valence (-22.0 +/- 1.4 for pattern A vs. -21.8 +/- 1.9 for pattern B). Thus, the greater mobility of pattern B LDL is due to similar net charge residing on a smaller particle. Comparison of subfractions in pattern B relative to pattern A LDL revealed greater surface potential in all pattern B subfractions and greater charge density in fractions of d > or = 1.032 g/ml. In a subset of subjects incubation with neuraminidase produced significant reductions in all LDL charge parameters for all subfractions, but did not abolish the differences between pattern A and B. Thus increased surface potential and charge density of unfractionated pattern B LDL is due both to charge properties of particles across the size and density spectrum as well as enrichment of pattern B LDL with smaller, denser particles that have higher surface charge density.
Neopterin as a Predictor of Total and Cardiovascular Mortality in Individuals Undergoing Angiography in the Ludwigshafen Risk and Cardiovascular Health Study (2009)

Neopterin is an independent predictor of all-cause and cardiovascular mortality in individuals with or without stable coronary artery disease.
Patient-reported outcomes (PROs) in KEYNOTE-921: Pembrolizumab (pembro) plus docetaxel for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). (2023)

129 Background: The double-blind, phase 3, randomized KEYNOTE-921 trial (NCT03834506) showed that pembro + docetaxel did not significantly improve rPFS or OS for pts with mCRPC treated with prior next-generation hormonal agent (NHA) therapy. We present PROs for pembro + docetaxel vs placebo + docetaxel in KEYNOTE-921. Methods: Pts were randomly assigned 1:1 to receive pembro 200 mg or placebo IV Q3W (≤35 cycles) + docetaxel 75 mg/m 2 IV Q3W (≤10 cycles) and prednisone 5 mg orally BID. PROs were evaluated in pts who received ≥1 dose of study treatment and had ≥1 PRO assessment. FACT-P and BPI-SF were administered at baseline, Q3W until wk 24, Q6W until wk 72, then Q12W for ≤2 y. A prespecified secondary end point was time to pain progression (TTPP) based on BPI-SF. Prespecified exploratory end points included least squares mean (LSM) change from baseline to wk 27 for FACT-P total and subscale scores (FACT-G total, TOI, FAPSI-6, FWB, PWB, and PCS) and wk 24 for BPI-SF scores (pain interference, pain severity, and worst pain), and time to deterioration (TTD) and overall improvement rate in FACT-P total and subscale scores. Differences were evaluated using 2-sided nominal P values not controlled for multiplicity. Results: Of 1030 pts enrolled, the PRO analysis population included 1028 (n = 514 in each arm). At the prespecified final analysis, median time from randomization to data cutoff of June 20, 2022, was 22.7 mo (range, 12.1-36.7). Completion rates for FACT-P and BPI-SF were &gt;78% at baseline, &gt;65% for FACT-P at wk 27, and &gt;63% for BPI-SF at wk 24. Median TTPP was 21.1 mo (95% CI, 13.7-NR) for pembro + docetaxel vs NR (95% CI, 13.8-NR) for placebo + docetaxel (HR, 1.05 [95% CI, 0.77-1.43]). No LSM differences were observed in FACT-P total scores with pembro + docetaxel (–5.31 [95% CI, –7.02 to –3.61]) vs placebo + docetaxel (–3.89 [95% CI, –5.59 to –2.19]) or BPI-SF scores. Median TTD in FACT-P total scores was 21.8 mo (95% CI, 20.0-NR) for pembro + docetaxel and NR (95% CI, 11.1-NR) for placebo + docetaxel (HR, 1.09 [95% CI, 0.88-1.35]). No differences were observed for TTD in FACT-G total, TOI, FAPSI-6, FWB, PWB, and PCS scores between groups. A numerically lower proportion of pts receiving pembro + docetaxel (39.9%) had improved + stable FACT-P total scores compared with placebo + docetaxel (45.3%). FACT-P and BPI-SF scores were generally maintained across all evaluated time points up to wk 81. Conclusions: HRQoL and disease-related symptom scores at all analyzed time points, as well as TTD and TTPP, were similar between the 2 trial arms. These data suggest that pembro + docetaxel did not negatively impact QoL in pts with mCRPC treated with prior NHA. Clinical trial information: NCT03834506 . [Table: see text]
Novel organic arsenic molecule darinaparsin: Development of IV and oral forms (2009)

8501 Background: Darinaparsin (ZIO-101) is a novel organic arsenical active against diverse cancers in vitro, and in vivo. Darinaparsin i.v. activity in lymphoma is being evaluated in a phase II study. Darinaparsin is orally bioavailable; the oral form is being investigated in two phase I studies in patients with advanced malignancies. Methods: Phase II trial is being conducted in patients diagnosed with advanced lymphomas who had ≥ 1 prior therapy. Patients receive 300 mg/m 2 /day of darinaparsin i.v. for 5 consecutive days every 28 days. Efficacy and safety are evaluated by standard criteria. Phase I oral dose escalation studies are being conducted in patients with advanced malignancies and explore safety, MTD, DLTs and preliminary efficacy of continuous and intermittent dosing schedules. Starting continuous dose is 100 mg BID for 3 weeks with 1 week rest, starting intermittent dose is 300 mg twice weekly for 3 weeks followed by 1 week rest. Results: The phase II study has accrued 28 lymphoma patients (21 non-Hodgkin's, 7 Hodgkin's); median age at baseline 61 years, ECOG ≤2, median number of prior therapies 3. Seventeen subjects have received at least 2 cycles of darinaparsin and are evaluable for efficacy. Of these, 1 subject (PTCL) has achieved a complete response, 3 - partial responses (2 marginal zone, 1 Hodgkin's), and 4 stable disease (2 PTCL, 1 DLBCL, 1 Hodgkin's). A total of 63 cycles of darinaparsin have been administered to subjects with lymphoma. No Gr. 3 or higher drug-related AEs were reported. Two SAEs were considered possibly drug-related (fall; neutropenic fever). Phase I studies accrued 35 patients; median age at baseline 58 years, ECOG ≤2, median number of prior therapies 3. Predominant tumor types include: colorectal (17), pancreatic (3), NHL (3). Current darinaparsin dose levels: continuous 200 mg BID, 2× weekly 900 mg. Of 18 patients evaluable for efficacy, 10 demonstrate SD ≥ 3 cycles. Oral darinaparsin bioavailability is 58%. Drug-related AEs include nausea/vomiting, fatigue, decreased appetite/anorexia. Conclusions: Darinaparsin is active in heavily pretreated patients with advanced lymphoma and has been very well tolerated. Oral darinaparsin is also well tolerated, and shows early activity. [Table: see text]
Klystrode experimental results (2003)

A 500-kW peak power, 50-kW average, 425-MHz Klystrode has been designed and built. The high-power Klystrode design evolved from earlier work on a new line of UHF TV Klystrodes. Experimental testing has proceeded in three phases. The initial testing was done on a beam simulation device to determine the characteristics of the gridded gun. The second phase consisted of low-duty-cycle, full-voltage and current RF testing on the Klystrode built for the contract. The third phase will continue the testing at the full specification conditions. The basic operating principles are summarized, and test results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Influence of Inter- and Intramolecular Hydrogen Bonding on Kemp Decarboxylations from QM/MM Simulations (2005)

The Kemp decarboxylation reaction for benzisoxazole-3-carboxylic acid derivatives has been investigated using QM/MM calculations in protic and dipolar aprotic solvents. Aprotic solvents have been shown to accelerate the rates of reaction by 7-8 orders of magnitude over water; however, the inclusion of an internal hydrogen bond effectively inhibits the reaction with near solvent independence. The effects of solvation and intramolecular hydrogen bonding on the reactants, transition structures, and the rate of reaction are elucidated using two-dimensional potentials of mean force (PMF) derived from free energy perturbation calculations in Monte Carlo simulations (MC/FEP). Free energies of activation in six solvents have been computed to be in close agreement with experiment. Solute-solvent interaction energies show that poorer solvation of the reactant anion in the dipolar aprotic solvents is primarily responsible for the observed rate enhancements over protic media. In addition, a discrepancy for the experimental rate in chloroform has been studied in detail with the conclusion that ion-pairing between the reactant anion and tetramethylguanidinium counterion is responsible for the anomalously slow reaction rate. The overall quantitative success of the computations supports the present QM/MM/MC approach, which features PDDG/PM3 as the QM method.
Performance analysis of power output of photovoltaic systems in San Diego County (2012)

Performance of photovoltaic (PV) systems installed in Southern California is analyzed. Measured power output of 400 PV sites, measured irradiation at 5 stations, and satellite-derived irradiation data are applied. Performance of the PV systems is estimated by using the satellite-derived irradiation data. Also, clear sky indices (kt) are obtained and compared for all these datasets. Over one year the largest hourly ramp was a 61% decrease based on the STC rating. The measured and satellite derived irradiation data are applied to evaluate the predictability of ramps. The effects of specific meteorological conditions, such as coastal marine layer clouds and frontal system effects, on occurrence of large ramps are investigated over the area. Satellite images are utilized to detect the weather condition for the days in which the ramps occurred.
An electrothermal model of memory switching in vertical polycrystalline silicon structures (1988)

The theoretical preswitching temperature, resistivity, and current-density distributions within the thin-film device were obtained from the solution of the transient two-dimensional heat equation. The results of the computer simulation, obtained for the case where conductivity is dependent on both temperature and electric field, show that current crowding occurs at the center of the device and that thermal runaway develops in a few tens of nanoseconds for voltages above a critical value. A simulated conductive irregularity forces the filament to nucleate away from the center and closer to or at the inhomogeneity. The excellent agreement between the experimental data and the simulation lends support to the idea that the fundamental switching mechanism is thermal in nature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Collusion-resistant intentional de-synchronization for digital video fingerprinting (2005)

A powerful class of attacks in multimedia fingerprinting is known as collusion attacks, where a clique of colluders, each having a copy of the same multimedia content with different fingerprint, combine their copies to form a colluded copy. In this paper, we propose a countermeasure against collusion attacks for digital video: pseudo-random intentional de-synchronization techniques. Each user's copy of video is slightly pseudo-randomly changed (de-synchronized) in such a way that these changes will not be noticeable for an individual copy, but will be significant enough to produce perceptual artifacts when multiple copies are combined (e.g., via averaging, replacement attacks, etc.). To achieve this task, we propose several novel effective techniques, including constrained random temporal and spatial sampling. We discuss feasibility issues and limitations of video de-synchronization, and present several examples.
Immunomodulatory Gene Therapy in Lysosomal Storage Disorders (2009)

Significant advances in therapy for lysosomal storage disorders have occurred with an accelerating pace over the past decade. Although enzyme replacement therapy has improved the outcome of lysosomal storage disorders, antibody responses have occurred and sometimes prevented efficacy, especially in cross-reacting immune material negative patients with Pompe disease. Preclinical gene therapy experiments have revealed the relevance of immune responses to long-term efficacy. The choice of regulatory cassette played a critical role in evading humoral and cellular immune responses to gene therapy in knockout mouse models, at least in adult animals. Liver-specific regulatory cassettes prevented antibody formation and enhanced the efficacy of gene therapy. Regulatory T cells prevented transgene directed immune responses, as shown by adoptive transfer of antigen-specific immune tolerance to enzyme therapy. Immunomodulatory gene therapy with a very low vector dose could enhance the efficacy of enzyme therapy in Pompe disease and other lysosomal storage disorders.
Query-time Entity Resolution (2007)

Entity resolution is the problem of reconciling database references corresponding to the same real-world entities. Given the abundance of publicly available databases that have unresolved entities, we motivate the problem of query-time entity resolution quick and accurate resolution for answering queries over such `unclean' databases at query-time. Since collective entity resolution approaches --- where related references are resolved jointly --- have been shown to be more accurate than independent attribute-based resolution for off-line entity resolution, we focus on developing new algorithms for collective resolution for answering entity resolution queries at query-time. For this purpose, we first formally show that, for collective resolution, precision and recall for individual entities follow a geometric progression as neighbors at increasing distances are considered. Unfolding this progression leads naturally to a two stage `expand and resolve' query processing strategy. In this strategy, we first extract the related records for a query using two novel expansion operators, and then resolve the extracted records collectively. We then show how the same strategy can be adapted for query-time entity resolution by identifying and resolving only those database references that are the most helpful for processing the query. We validate our approach on two large real-world publication databases where we show the usefulness of collective resolution and at the same time demonstrate the need for adaptive strategies for query processing. We then show how the same queries can be answered in real-time using our adaptive approach while preserving the gains of collective resolution. In addition to experiments on real datasets, we use synthetically generated data to empirically demonstrate the validity of the performance trends predicted by our analysis of collective entity resolution over a wide range of structural characteristics in the data.
Fast Turnaround HLS Debugging Using Dependency Analysis and Debug Overlays (2020)

High-level synthesis (HLS) has gained considerable traction over recent years, as it allows for faster development and verification of hardware accelerators than traditional RTL design. While HLS allows for most bugs to be caught during software verification, certain non-deterministic or data-dependent bugs still require debugging the actual hardware system during execution. Recent work has focused on techniques to allow designers to perform in-system debug of HLS circuits in the context of the original software code; however, like RTL debug, the user must still determine the root cause of a bug using small execution traces, with lengthy debug turns. In this work, we demonstrate techniques aimed at reducing the time HLS designers spend performing in-system debug. Our approaches consist of performing data dependency analysis to guide the user in selecting which variables are observed by the debug instrumentation, as well as an associated debug overlay that allows for rapid reconfiguration of the debug logic, enabling rapid switching of variable observation between debug iterations. In addition, our overlay provides additional debug capability, such as selective function tracing and conditional buffer freeze points. We explore the area overhead of these different overlay features, showing a basic overlay with only a 1.7% increase in area overhead from the baseline debug instrumentation, while a deluxe variant offers 2×--7× improvement in trace buffer memory utilization with conditional buffer freeze support.
Structure of a particle-laden round jet (1992)

The interaction of solid particles with the temporal features of a turbulent flow has direct relevance to problems in particle and spray combustion and the processing of particulate solids. The object of the present study was to examine the behaviour of particles in a jet dominated by vortex ring structures. An axisymmetric air jet laden with 55 μm glass particles was forced axially with an acoustic speaker to organize the vortex ring structures rolling up in the free shear layer downstream of the nozzle exit. Visualization studies of forced and unforced flow with Reynolds number of the order of 20000 were completed using a pulsed copper vapour laser. Instantaneous photographs and videotapes of strobed forced flow show that particles become clustered in the saddle regions downstream of the vortex rings and are propelled away from the jet axis by the outwardly moving flow in these regions. Phase-averaged spatial distribution of particle number density computed from digitized photographs and phase-averaged particle velocity measurements yield further evidence that local particle dispersion and concentration are governed by convection due to large-scale turbulence structures. The large-scale structures and convection mechanisms were shown to persist for particle-to-air mass loading ratios up to 0.65.
3933 Study on Smooth Movement of a Robot in Dynamic Environments (2005)

It is important for a robot to avoid collision with obstacles during its moving to a goal and a quick response, smooth change of the velocity and the steering of the robot are required, and especially the obstacles are moving. A simple fuzzy control system to avoid collision is presented here. In the system, the collision dangerous degree is judged according to the real distance from the robot to the moving obstacles and the initial minimum safety spacing. The necessary deceleration and the steering for avoiding the collision can be navigated using the fuzzy inference, which only needs to input one variable of the dangerous degree. Moreover, a predicting simulation is used to judger the danger of the robot in the next cycle, and the control values are adjusted according to the predicting simulation results in order to make the robot move smoothly.
Current-Fed Dual Inductor Push-Pull Partial Power Converter (2022)

Conventional full power dc-dc converters are processing the whole power flowing from the source to the load, which critically limits the overall efficiency of the system. Coming to the fact that the converter can perform the required functions by processing only the mandatory fraction of power, which is called power processing. In this paper, a Series Partial Power Converter (S-PPC) based on the current-fed push-pull dc-dc converter is presented. In order to get the full benefit of the S-PPC, the converter should process power less than 25% of the overall system power. Current-fed push-pull converter modulation is designed to ensure that all switches are operating at soft-switching. Basic system analysis and system simulation are discussed in the paper
Reliability Analysis of Physically Unclonable Function by Using Aging Variability Simulation (2022)

We applied Monte Carlo (MC) aging simulation flow to explain measured aging effects of PUF (Physically Unclonable Function) circuit. Simulation data provides a good understanding of how PUF circuit stability is degraded with the NBTI effect. Procedure of using MC aging simulation flow to predict PUF stability is explained in detail. Result from simulation is well matching with the measured data when the variability model is correctly extracted considering MOSFET device size. This flow was used to predict the stability of different types of PUF designs.
Potentiation of the insulinotropic and hypoglycemic actions of gliquidone by succinic acid esters (1997)

info:eu-repo/semantics/published
Evaluation of pulsed diode end-pumped Ytterbium doped sesquioxides: comparison of Sc2O3, Y2O3 and Lu2O3 (2005)

This paper deals with the thermal and optical properties of Ytterbium doped sesquioxide crystals. Thermal conductivities and performances are compared for different pumping transitions. We show that the zero-line is unsuitable for pulsed diode pumping.