gebhart/patrepeval huggingface dataset:
Enhancement in the Magnetostriction of Sintered Cobalt Ferrite by Making Self-Composites from Nanocrystalline and Bulk Powders (2012)

Sintered polycrystalline cobalt ferrite is a potential magnetostrictive smart material for applications as sensors and actuators. A novel concept of enhancing the magnetostrictive strain of sintered cobalt ferrite by making self-composites from nanosized and bulk powders with different particle sizes of the same material as components is reported. The self-composites give higher magnetostriction coefficient and strain derivative when compared to the sintered products obtained from the individual powders. The individual components give a maximum magnetostriction up to ~310 ppm, whereas up to ~370 ppm is obtained for a two-component system consisting of powders of two different sizes. On the other hand, a three-component self-composite made from starting powders of 3 nm, 40 nm and >1 μm give very high magnetostriction of ~400 ppm at 800 kA/m, suitable for making devices.
Two decades of new drug discovery and development for Alzheimer's disease (2017)

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.
1156: The Impact of Cautery vs Cautery Free Preservation of the Neurovascular Bundle on Return of Potency in Robot Assisted Laparoscopic Radical Prostatectomy (RLP) (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 9:00 am - 12:00 pm1 Apr 20061156: The Impact of Cautery vs Cautery Free Preservation of the Neurovascular Bundle on Return of Potency in Robot Assisted Laparoscopic Radical Prostatectomy (RLP) Thomas E. Ahlering, Garret Matsunaga, James F. Borin, and Douglas W. Skarecky Thomas E. AhleringThomas E. Ahlering More articles by this author , Garret MatsunagaGarret Matsunaga More articles by this author , James F. BorinJames F. Borin More articles by this author , and Douglas W. SkareckyDouglas W. Skarecky More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33381-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1156: The Impact of Cautery vs Cautery Free Preservation of the Neurovascular Bundle on Return of Potency in Robot Assisted Laparoscopic Radical Prostatectomy (RLP)." The Journal of Urology, 175(4S), pp. 371–372 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 371-372 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Thomas E. Ahlering More articles by this author Garret Matsunaga More articles by this author James F. Borin More articles by this author Douglas W. Skarecky More articles by this author Expand All Advertisement PDF downloadLoading ...
Domain-Specific Human-Inspired Binarized Statistical Image Features for\n Iris Recognition (2018)

Binarized statistical image features (BSIF) have been successfully used for\ntexture analysis in many computer vision tasks, including iris recognition and\nbiometric presentation attack detection. One important point is that all\napplications of BSIF in iris recognition have used the original BSIF filters,\nwhich were trained on image patches extracted from natural images. This paper\ntests the question of whether domain-specific BSIF can give better performance\nthan the default BSIF. The second important point is in the selection of image\npatches to use in training for BSIF. Can image patches derived from\neye-tracking experiments, in which humans perform an iris recognition task,\ngive better performance than random patches? Our results say that (1)\ndomain-specific BSIF features can out-perform the default BSIF features, and\n(2) selecting image patches in a task-specific manner guided by human\nperformance can out-perform selecting random patches. These results are\nimportant because BSIF is often regarded as a generic texture tool that does\nnot need any domain adaptation, and human-task-guided selection of patches for\ntraining has never (to our knowledge) been done. This paper follows the\nreproducible research requirements, and the new iris-domain-specific BSIF\nfilters, the patches used in filter training, the database used in testing and\nthe source codes of the designed iris recognition method are made available\nalong with this paper to facilitate applications of this concept.\n
High speed cellular array computer realizations for low power applications (2004)

In this paper a design method for building high speed array computers on a single chip is demonstrated with two example realizations. The key idea in the method is that an array computer can be built using reusable, relatively simple building blocks. All necessary memory is distributed among processing units. The number of processing units in the array computer is selected based on speed requirements, yielding a low power, small die area realization. Two different measured array processor realizations designed using the method are depicted.
Creation of Cu2O@TiO2 Composite Photocatalysts with p–n Heterojunctions Formed on Exposed Cu2O Facets, Their Energy Band Alignment Study, and Their Enhanced Photocatalytic Activity under Illumination with Visible Light (2014)

The creation of photocatalysts with controlled facets has become an important approach to enhance their activity. However, how the formation of heterojunctions on exposed facets could affect their photocatalytic performance ranking had not yet been investigated. In this study, Cu2O@TiO2 core-shell structures were created, and Cu2O/TiO2 p-n heterojunctions were formed on various exposed facets of Cu2O cubes, Cu2O cuboctahedra, and Cu2O octahedra, respectively. These Cu2O@TiO2 polyhedra demonstrated an enhanced photocatalytic degradation effect on Methylene Blue (MB) and 4-nitrophenol (4-NP) under visible light illumination, because of the enhanced charge carrier separation by the formation of Cu2O@TiO2 p-n heterojunctions. It was further found that their photocatalytic performance was also facet-dependent as pure Cu2O polyhedra, while the photocatalytic performance ranking of these Cu2O@TiO2 polyhedra was different with that of their corresponding Cu2O polyhedron cores. By the combination of optical property measurement and XPS analysis, the energy band alignments of these Cu2O@TiO2 polyhedra were determined, which demonstrated that Cu2O@TiO2 octahedra had the highest band offset for the separation of charge carriers. Thus, the charge-carrier-separation-driven force in Cu2O@TiO2 polyhedra was different from their corresponding Cu2O polyhedron cores, which resulted in their different surface photovoltage spectrum (SPS) responses and different photocatalytic performance rankings.
Synthesis of mesoporous aluminophosphates using surfactants with long alkyl chain lengths and triisopropylbenzene as a solubilizing agent (1998)

Mesostructured organo-aluminophosphates were prepared by using surfactants with long alkyl chain lengths (C16 and C22) and by utilizing solubilization of triisopropylbenzene; calcination of the mesostructured materials yielded thermally stable mesoporous aluminophosphates with surface areas >700 m2 g–1 and with pore diameters in the range 1.8–3.9 nm.
Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer (2012)

Cancer and atherosclerosis are major causes of death in western societies. Deregulated cell death is common to both diseases, with significant contribution of inflammatory processes and oxidative stress. These two form a vicious cycle and regulate cell death pathways in either direction. This raises interest in antioxidative systems. The human enzymes paraoxonase-2 (PON2) and PON3 are intracellular enzymes with established antioxidative effects and protective functions against atherosclerosis. Underlying molecular mechanisms, however, remained elusive until recently. Novel findings revealed that both enzymes locate to mitochondrial membranes where they interact with coenzyme Q10 and diminish oxidative stress. As a result, ROS-triggered mitochondrial apoptosis and cell death are reduced. From a cardiovascular standpoint, this is beneficial given that enhanced loss of vascular cells and macrophage death forms the basis for atherosclerotic plaque development. However, the same function has now been shown to raise chemotherapeutic resistance in several cancer cells. Intriguingly, PON2 as well as PON3 are frequently found upregulated in tumor samples. Here we review studies reporting PON2/PON3 deregulations in cancer, summarize most recent findings on their anti-oxidative and antiapoptotic mechanisms, and discuss how this could be used in putative future therapies to target atherosclerosis and cancer.
Editorial: Experimental Hernia Research From Bench to Bedside and Translational Perspectives (2021)

EditorialExperimental Hernia Research from Bench to Bedside and Translational PerspectiveHernia repair has been the pioneering field for innovative surgical techniques and devices. The past two decades have been a period of steady progress in order to reduce the incidence of chronic pain, raise the standards of elective surgery and develop feasible approaches for complex cases. The enormous number of procedures allows high quality clinical research and substantial support for experimental trials. This has led to constant influx of knowledge obtained in hernia research to other surgical domains, eg plastic and trauma surgery.We are pleased to present this research topic, containing valuable contributions. These works reflect the continuous interest and striving activity of the research community and clinicians.
The Macrocyclic Peptide Natural Product CJ-15,208 Is Orally Active and Prevents Reinstatement of Extinguished Cocaine-Seeking Behavior (2013)

The macrocyclic tetrapeptide natural product CJ-15,208 (cyclo[Phe-d-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor (KOR) antagonist activity after oral administration. CJ-15,208 antagonized a centrally administered KOR selective agonist, providing strong evidence it crosses the blood-brain barrier to reach KOR in the CNS. Orally administered CJ-15,208 also prevented both cocaine- and stress-induced reinstatement of extinguished cocaine-seeking behavior in the conditioned place preference assay in a time- and dose-dependent manner. Thus, CJ-15,208 is a promising lead compound with a unique activity profile for potential development, particularly as a therapeutic to prevent relapse to drug-seeking behavior in abstinent subjects.
Flow optimization in IP networks with fast proactive recovery (2008)

A powerpoint presentation is given. The paper discusses flow optimization in IP networks with fast proactive recovery. IP fast rerouting includes equal-cost multiple paths, loop free alternate and multihop repair path. The main purpose of the optimization model is to exhibit the efficiency of the IPFR , to develop an efficient resolution method based on iterative heuristic partitioning method by numerical experiments, and to be able to eliminate almost all( disadvantageous) MHRP paths.
Multibit Error-Correction Methods for Latency-Constrained Flash Memory Systems (2009)

This paper presents multibit error-correction schemes for nor Flash used specifically for execute-in-place applications. As architectures advance to accommodate more bits/cell and geometries decrease to structures that are smaller than 32 nm, single-bit error-correction codes (ECCs) are unable to compensate for the increasing array bit error rates, making it imperative to use 2-b ECC. However, 2-b ECC algorithms are complex and add a timing overhead on the memory read access time. This paper proposes low-latency multibit ECC schemes. Starting with the binary Bose-Chaudhuri-Hocquenghem (BCH) codes, an optimized scheme is introduced which combines a multibit error-correcting BCH code with Hamming codes in a hierarchical manner to give an average latency as low as that of the single-bit correcting Hamming decoder. A Hamming algorithm with 2-b error-correcting capacity for very small block sizes (< 1 B) is another low-latency multibit ECC algorithm that is discussed. The viability of these methods and algorithms with respect to latency and die area is proved vis-a¿-vis software and hardware implementations.
Anomalous Contraction Scour? Vertical-Contraction Case (2010)

Clear-water scour due to a short vertical (pressure flow) contraction was investigated in a laboratory channel. Two approach velocities were studied for a (nominally) single configuration of depth and degree of contraction, with experiments conducted for various durations up to a maximum of 48 h, and the evolution of the scour hole over time monitored. The location of maximum scour in both cases was observed to occur downstream of the contraction, with maximum scour depths substantially in excess of values predicted by published models, even though equilibrium scour conditions were not reached.
Development of a Novel Enzyme/Prodrug Strategy for Gene Therapy of Breast Cancer (2000)

Abstract : We developed and tested a novel enzyme/prodrug strategy for cancer gene therapy using Carboxypeptidase A (CPA) to enzymatically convert the prodrug methotrexate-Alpha-phenylalanine (MTX-Phe) to methotrexate (MTX). CPA is normally synthesized as a zymogen that requires proteolytic removal of its pro-peptide by trypsin in order to gain catalytic activity. In Specific Aim I in order to use CPA as a therapeutic gene we engineered a battery of mutant forms of CPA which were designed to be activated by normal cellular secretory processes. We found that the best mutant, termed CPA(sub ST3), was secreted from tumor cells in an active form and biochemical analysis revealed that it had similar activity and substrate specificity to the wild-type enzyme. In Specific Aim II we produced recombinant retroviruses coding for this mutant form of CPA and demonstrated that tumor cells infected with these viruses were potently sensitized to MTX-Phe and that there was a significant 'bystander effect' even when less than 10% of the tumor cells were expressing CPA. We were unable to carry-out in vivo analysis of the MTX-Phe based system due to the unexpected instability of MTX-Phe in vivo. However, we did synthesize an active-site mutant of CPA(sub ST3) to convert the stable prodrug MTX-3-cyclopentyl-tyrosine.
Fluoxetine treatment increases trabecular bone formation in mice (2006)

Mounting evidence exists for the operation of a functional serotonin (5-HT) system in osteoclasts and osteoblasts, which involves both receptor activation and 5-HT reuptake. In previous work we showed that the serotonin transporter (5-HTT) is expressed in osteoclasts and that its activity is required by for osteoclast differentiation in vitro. The purpose of the current study was to determine the effect of treatment with fluoxetine, a specific serotonin reuptake inhibitor, on bone metabolism in vivo. Systemic administration of fluoxetine to Swiss-Webster mice for 6 weeks resulted in increased trabecular BV and BV/TV in femurs and vertebrae as determined by micro-computed tomography (microCT). This correlated with an increase in trabecular number, connectivity, and decreased trabecular spacing. Fluoxetine treatment also resulted in increased volume in vertebral trabecular bone. However, fluoxetine-treated mice were not protected against bone loss after ovariectomy, suggesting that its anabolic effect requires the presence of estrogen. The effect of blocking the 5-HTT on bone loss following an LPS-mediated inflammatory challenge was also investigated. Subcutaneous injections of LPS over the calvariae of Swiss-Webster mice for 5 days resulted in increased numbers of osteoclasts and net bone loss, whereas new bone formation and a net gain in bone mass was seen when LPS was given together with fluoxetine. We conclude that fluoxetine treatment in vivo leads to increased bone mass under normal physiologic or inflammatory conditions, but does not prevent bone loss associated with estrogen deficiency. These data suggest that commonly used anti-depressive agents may affect bone mass.
Nonagenarians in internal medicine: characteristics, outcomes and predictors for in-hospital and post-discharge mortality. (2010)

Hospitalized nonagenarians comprise a growing group with distinct characteristics and increasing significance in the daily practice of internal medicine departments. Comprehensive assessment of the elderly at admission together with identification of the above clinical and laboratory risk factors for mortality will help determine in-hospital management, discharge planning and rehabilitation programs.
Publisher’s Note: Observation of Optomechanical Strain in a Cold Atomic Cloud [Phys. Rev. Lett. 119, 163201 (2017)] (2017)

This corrects the article DOI: 10.1103/PhysRevLett.119.163201.
Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent (2009)

Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations in the sEH gene, designated EPHX2, are associated with ischemic stroke risk. In experimental studies, sEH inhibition and gene deletion reduce infarct size after focal cerebral ischemia in mice. Although the precise mechanism of protection afforded by sEH inhibition remains under investigation, EETs exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and post-ischemic inflammation. Herein we argue that by capitalizing on this broad protective profile, sEH inhibition represents a prototype "combination therapy" targeting multiple mechanisms of stroke injury with a single agent.
The Chemistry of Natural Products. Volume II. (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Natural Products. Volume II.Carl DjerassiCite this: J. Am. Chem. Soc. 1959, 81, 22, 6092Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/ja01531a072https://doi.org/10.1021/ja01531a072research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12 (2006)

Four phosphinic peptide libraries with compounds having the general formula p-Br-Ph-(PO2-CH2)-Xaa'-Yaa'-Zaa'-NH2 have been prepared and screened against 10 matrix metalloproteinases (MMPs). We identified two phosphinic peptides with Ki values of 0.19 and 4.4 nM toward MMP-12 (macrophage elastase) that are more than 2-3 orders of magnitude less potent toward the other MMPs tested. These highly selective MMP-12 inhibitors contain a Glu-Glu motif in their Yaa'-Zaa' positions. Incorporation of this Glu-Glu motif into the sequence of a nonspecific fluorogenic peptide cleaved by MMPs provides a highly selective substrate for MMP-12. A model of one of these inhibitors interacting with MMP-12 suggests that the selectivity observed might be due, in part, to the presence of two unique polar residues in MMP-12, Thr239 and Lys177. These MMP-12-selective inhibitors may have important therapeutic applications to diseases in which MMP-12 has been suggested to play a key role, such as in emphysema, atherosclerosis, and aortic abdominal aneurysm.
Formation of Tertiary Amides and Dihydrogen by Dehydrogenative Coupling of Primary Alcohols with Secondary Amines Catalyzed by Ruthenium Bipyridine‐Based Pincer Complexes (2013)

Abstract Dehydrogenative coupling of primary alcohols with secondary amines to form tertiary amides and dihydrogen (H 2 ) is efficiently catalyzed by bipyridyl‐based ruthenium pincer complexes (0.2–1 mol%) under neutral conditions (in case of the dearomatized complexes), or with added catalytic amount of base. The reaction is sensitive to steric hindrance; in the case of amidation of bulky secondary amines a less sterically hindered complex is more efficient. Selective acylation of primary amines in the presence of secondary amines was also demonstrated. magnified image
Multimicrophone signal-processing technique to remove room reverberation from speech signals (1977)

It is well known that room reverberation can significantly impair one’s perception of sounds recorded by a microphone in that room. Acoustic recordings produced in untreated rooms are characterized by a hollow echolike quality resulting from not locating the microphone close to the source. In this paper we discuss a multimicrophone digital processing scheme for removing much of the degrading distortion. To accomplish this the individual microphone signals are divided into frequency bands whose corresponding outputs are cophased (delay differences are compensated) and added. Then the gain of each resulting band is set based on the cross correlation between corresponding microphone signals in that band. The reconstructed broadband speech is perceived with considerably reduced reverberation.
Transplantation of umbilical cord blood in Fanconi's anemia. (1990)

It has been shown that human umbilical cord blood contains stem/progenitor cells comparable in number to that of adult bone marrow. We report here the first successful cases of transplantation of umbilical cord blood cells. The patients were suffering from Fanconi's anemia, complicated by severe aplastic anemia. During pregnancy, it was shown that the mother was carrying a sibling unaffected by the disease and with HLA identical to the patient. Cord blood was collected and frozen in liquid nitrogen at birth. After conditioning with low-dose cyclophosphamide (20 mg/kg) and thoraco-abdominal irradiation (5 grays), the patients received a cord blood transplant of thawed cells. Three patients have been transplanted without any immediate side-effect. One has not enough follow-up, but two patients are alive and well with complete donor hematologic reconstitution and no chronic graft versus host disease. Potential developments of this technique are an extension of applicability with regard to other diseases that might be transplanted and whether such transplants can be performed in adults. The relative immaturity of the lymphoid system at birth may be advantageous in decreasing the graft versus host reaction if these cells are used in a mismatched transplantation. Cord blood cell banks may be useful for transplants in patients lacking an HLA-identical donor.