gebhart/patrepeval huggingface dataset:
Implementation of an extended prediction self-adaptive controller using LabVIEW<sup>TM</sup> (2015)

The implementation of the Extended Prediction Self-Adaptive Controller is presented in this paper. It employs LabVIEW <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> graphical programming of industrial equipment and it is suitable for controlling fast processes. Three different systems are used for implementing the control algorithm. The research regarding the controller design using graphical programming demonstrates that a single advanced control application can run on Windows, real time operating systems and FPGA targets without requiring significant program modifications. The most appropriate device may be selected according to the required processing time of the control signal and of the application. A relevant case study is used to exemplify the procedure.
Precision Medicine in Hymenoptera Venom Allergy: Diagnostics, Biomarkers, and Therapy of Different Endotypes and Phenotypes (2020)

Allergic reactions to stings of Hymenoptera species may be severe and are potentially fatal deviations of the immunological response observed in healthy individuals. However, venom-specific immunotherapy (VIT) is an immunomodulatory approach able to cure venom allergy in the majority of affected patients. An appropriate therapeutic intervention and the efficacy of VIT not only depend on a conclusive diagnosis, but might also be influenced by the patient-specific manifestation of the disease. As with other diseases, it should be borne in mind that there are different endotypes and phenotypes of venom allergy, each of which require a patient-tailored disease management and treatment scheme. Reviewed here are different endotypes of sting reactions such as IgE-mediated allergy, asymptomatic sensitization or a simultaneous presence of venom allergy and mast cell disorders including particular considerations for diagnosis and therapy. Additionally, phenotypical manifestations of venom allergy, as e.g. differences in age of onset and disease severity, multiple sensitization or patients unsusceptible to therapy, are described. Moreover, biomarkers and diagnostic strategies that might reflect the immunological status of the patient and their value for therapeutic guidance are discussed. Taken together, the increasing knowledge of different disease manifestations in venom hypersensitivity and the growing availability of diagnostic tools open new options for the classification of venom allergy and, hence, for personalized medical approaches and precision medicine in Hymenoptera venom allergy.
Quantitative Evaluation of Glycine Crystal Growth from Solution by a Phase Field Simulation (2015)

Quantitative evaluation of crystal growth is important to understand the mechanism upon crystallization from supersaturated solution. In the present work, the prediction of crystal growth was quantitatively performed by phase-field simulation. The program on the crystal growth following the concentration difference as the driving force was developed. The validity of simulation results was evaluated by comparing the crystal morphology obtained by phase-field simulation with experimental results. The rate of crystal growth was estimated by calculating the change in crystal morphology against time. The crystal growth rate was different between constant and non-constant supersaturation ratios. The growth rate on each face strongly depended on the supersaturation ratio. This simulation method would help to design operating conditions for obtaining the desired crystal morphology. We could quantitatively predict the crystal growth by introducing the substance-specific parameters.
Age-adjusted Charlson Comorbidity Index as a prognostic factor for radical prostatectomy outcomes of very high-risk prostate cancer patients (2018)

The ACCI is an effective prognostic factor for other-cause survival and OS in very high-risk PC patients. RP should be considered carefully for patients with an ACCI score >3.
Generation of induced pluripotent stem cells from a patient with Best Dystrophy carrying 11q12.3 (BEST1 (VMD2)) mutation (2018)

Best disease (BD), also termed Best vitelliform macular dystrophy (BVMD), is a juvenile-onset form of macular degeneration and central visual loss. In this report, we generated an induced pluripotent stem cell (iPSC) line, TVGH-iPSC-012-04, from the peripheral blood mononuclear cells of a female patient with BD by using the Sendai virus delivery system. The resulting iPSCs retained the disease-causing DNA mutation, expressed pluripotent markers and could differentiate into three germ layers. We believe that BD patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease.
Extract of Scutellaria baicalensis inhibits dengue virus replication (2013)

Our study demonstrates the in vitro anti-dengue virus replication property of S. baicalensis against all the four DENV serotypes investigated. The extract reduced DENV infectivity and replication in Vero cells. The extract was rich in baicalein, and could be considered for potential development of anti-DENV therapeutics.
Incremental Mining of Across-streams Sequential Patterns in Multiple Data Streams (2011)

Sequential pattern mining is the mining of data sequences for frequent sequential patterns with time sequence, which has a wide application. Data streams are streams of data that arrive at high speed. Due to the limitation of memory capacity and the need of real-time mining, the results of mining need to be updated in real time. Multiple data streams are the simultaneous arrival of a plurality of data streams, for which a much larger amount of data needs to be processed. Due to the inapplicability of traditional sequential pattern mining techniques, sequential pattern mining in multiple data streams has become an important research issue. Previous research can only handle a single item at a time and hence is incapable of coping with the changing environment of multiple data streams. In this paper, therefore, we propose the IAspam algorithm that not only can handle a set of items at a time but also can incrementally mine across-streams sequential patterns. In the process, stream data are converted into bitmap representation for mining. Experimental results show that the IAspam algorithm is effective in execution time when processing large amounts of stream data.
Benefits of Network Coding in Disruption Tolerant Networks (2010)

In this report, we investigate the benefits of applying a form of network coding known as Random Linear Coding (RLC) to unicast communications in mobile Disruption Tolerant Networks (DTNs). Under RLC, DTN nodes store and forward random linear combinations of packets as they encounter other DTN nodes. We first consider RLC applied to a single block of K packets where (a) all K packets have the same source and destination, (b) the K packets have different sources but a common destination and (c) the K packets each have a different source/destination pair; we also consider the case where blocks of K packets arrive according to a Poisson bulk arrival process. The performance metric of interest is the delay until the last packet in a block is delivered. We show that for the single block case, when bandwidth is constrained, applying RLC over packets destined to the same node achieves (with high probability) the minimum delay to deliver the block of data. We find through simulation that the benefit over non-network-coded packet forwarding increases further when buffer space within DTN nodes is limited. For the case of multiple blocks, our simulations show that RLC offers only slight improvement over the non-coded scenario when only bandwidth is constrained, but more significant benefits when both bandwidth and buffers are constrained. We remark that when the network is relatively loaded, the RLC scheme achieves improvements over non-coded schemes only if the spreading of the information is appropriately controlled.
<title>Microfabricated electric impedance chamber for the electrical characterization of single cells</title> (1998)

Micromachining technologies were applied to fabricate metal- electrode-instrumented microchannels with cross-sectional dimensions similar in size to blood cells. The instruments enable electric impedance measurement of femptoliter quantities of materials and solutions. The completed micro- electric impedance devices were characterized with varying concentrations of phosphate buffered saline solutions, DI water, and air in the recording zone. With the microdevices on the stage of an inverted light microscope, individual living cells were positioned tightly between metal electrodes using mechanical suction. Impedance spectra form 100 Hz to 2 MHz measured in isolated toadfish red blood cells (RBCs) and human neutrophils were distinct and demonstrated the ability to permeate the cell membrane at high frequency. The cell/shunt path cut-off frequency were approximately 400 kHz at -3dB indicating that non- invasive electric impedance characterization of the cytoplasm may be feasible for his configuration. In addition, the area specific membrane capacitance was estimated for both cell types by fitting the data to a simple RC circuit model.
Display Lighting Preferences (1974)

A pair of display boxes containing indentical objects displayed under six different lighting conditions were viewed by 134 individual observers. Each observer had to make a forced-choice pair comparison in response to six questions concerning different aspects of the lighted object. Relative rankings of the six lighting conditions are given. The direction from which the light source shines on the object is important with the most preferred to least preferred directions being front, top, and back, respectively. If two source locations are used, the sources should be located in as different directions as possible. Incandescent spot lights were preferred over fluorescent lights, and light intensity was only important for initially attracting attention. It also appears that display lighting is more effective for visually simple objects such as household applicances than for visually complicated objects such as much household furniture.
Structural studies of tRNAs by capillary high performance liquid chromatography/electrospray mass spectrometry. (1995)

Capillary high performance liquid chromatography/ electrospray mass spectrometry (LC/ ESI/MS) was applied to studies of nucleic acids. Since the presence of salt adducts obscures the molecular peaks and hinders the precise determination of molecular mass, conditions were sought in which effective online desalting and efficient ionization could be achieved simultaneously. In the presence of triethylamine, which is routinely used for the reversed-phase separation of nucleic acid, small oligo-nucleotides could be measured satisfactorily, while RNA tended to show more pronounced adduct peaks. When tributylamine was used instead of the shorter analogue, the adduct peak formation was well suppressed, and the hydrophobic nature of the counter ion made the nucleotides binding to the column tighter, resulting in the better chromatographic separation. The efficient ionization and suppression of the ion adducts make it possible to determine precisely the molecular mass of large nucleotides such as tRNA.
Efficient Sensor Fingerprint Matching Through Fingerprint Binarization (2012)

It is now established that photo-response nonuniformity noise pattern can be reliably used as a fingerprint to identify an image sensor. The large size and random nature of sensor fingerprints, however, make them inconvenient to store. Further, associated fingerprint matching method can be computationally expensive, especially for applications that involve large-scale databases. To address these limitations, we propose to represent sensor fingerprints in binary-quantized form. It is shown through both analytical study and simulations that the reduction in matching accuracy due to quantization is insignificant as compared to conventional approaches. Experiments on actual sensor fingerprint data are conducted to confirm that only a slight increase occurred in the probability of error and to demonstrate the computational efficacy of the approach.
Paper #55 Effects of administration of transforming growth factor‐beta into the bone tunnel on tendon graft healing within the tunnel in anterior cruciate ligament reconstruction (2003)

A firm attachment of a tendon graft to the bone is a significant factor for the success in anterior cruciate ligament (ACL) reconstruction. Our previous studies have shown that the bonding strength of the flexor tendon autograft to the tunnel wall is inferior to that of the bone-patellar tendon-bone (BTB) graft in the earliest several weeks after ACL reconstruction (JARR, 2001). Therefore, it is important to study therapeutic methods to increase the bonding strength of the flexor tendon graft in this early phase. It has been well known that transforming growth factor-beta (TGF-beta) stimulates the cell proliferation and collagen synthesis in tendon fibroblasts. Therefore, we have hypothesized that administration of TGF-beta 1 into the bone tunnel may enhance in vivo healing of flexor tendon graft within the tunnel in ACL reconstruction. The purpose of this study is to test this hypothesis with a canine model.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Novel Derivatives of Benzofuran. Part 2. The Synthesis and Antimicrobial Activity of Some Novel 1‐(1‐Benzofuran‐2‐yl)‐2‐mesitylethanone Derivatives. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Conversion of asynchronous 10 Gbit/s Ethernet NRZ frame into a synchronous RZ frame and multiplexing to 170 Gbit/s (2010)

This paper presents an optical circuit for frame synchronization and pulse compression of 10G Ethernet frames with 12000 bits and multiplexing to a 170 Gbit/s optical timedivision multiplexed data stream.
Curative treatments and survival benefit in elderly patients with hepatocellular carcinoma: A SEER population-based analysis. (2015)

355 Background: Transplant, resection, and ablation are potentially curative treatments for hepatocellular carcinoma (HCC) with limited outcome data in young-old (65-74) and older (≥75) patients. Methods: We evaluated curative treatment and relative survival (RS) outcomes in patients with HCC in 3 age groups (&lt;65 years, 65-74 years, and ≥75 years). Patients with HCC diagnostic codes (histology 8,170-8,175, morphology C22) were identified in the SEER 18 database from 2000 to 2011. Treatments included curative (transplant, resection, radiofrequency ablation (RFA), and other ablations) and palliative therapies. Primary outcome was 5 year RS. Statistical analysis was performed using Kaplan-Meier and Chi-Square tests. Results: We identified 29,654 cases. The mean age was 62 years with almost 40% of HCC cases in patients over 65 years old. Potentially curable, localized stage rates were similar in all age groups, 46%, 48% and 46%, respectively. As a result of less resection and rare transplant use, fewer cases underwent curative treatments in the group 75 years and older in comparison to all other age groups (15% vs. 27%, p = 0.001). Five-year RS in all 3 age groups (&lt;65 years, 65-74 years, and ≥75 years) was better after resection relative to RFA (47% vs. 35% p&lt;0.0001, 44% vs. 37%, p=0.0093, and 43% vs. 28% p=0.0002). The highest survival was seen after liver transplant. Interestingly, among transplanted patients with HCC, 13% were 65-75 years old. Five-year RS was similar in transplanted patients 65-75 vs. those under 65 (76% vs 74% p=0.65). Conclusions: The use of curative treatments for HCC significantly decreases with age, yet there are clear survival benefits in elderly patients receiving such. Even when considering transplant, the data shows that outcome is as good in elderly patients as in younger patients. The benefit of hepatic resection appears to be superior compared to RFA in all age groups, in our analysis. [Table: see text]
λ3/1000 Plasmonic Nanocavities for Biosensing Fabricated by Soft UV Nanoimprint Lithography (2011)

Arrays of plasmonic nanocavities with very low volumes, down to λ(3)/1000, have been fabricated by soft UV nanoimprint lithography. Nearly perfect omnidirectional absorption (3-70°) is demonstrated for the fundamental mode of the cavity (λ ≃ 1.15 μm). The second-order mode exhibits a sharper resonance with strong angular dependence and total optical absorption when the critical coupling condition is fulfilled (45-50°, λ ≃ 750 nm). It leads to high refractive index sensitivity (405 nm/RIU) and figure of merit (∼21) and offers new perspectives for efficient biosensing experiments in ultralow volumes.
ON THE MODEL-BASED DESIGN OF SEMI-ACTIVE AND ACTIVE SUSPENSION FOR PRIVATE CARS (1992)

Using a full car model, this paper presents the design of semi-active and active suspensions with four types of controller. The types considered are: (1) Proportional Integral Derivative (PID); (2) Linear Quadratic Regulator (LQR); (3) Linear Quadratic Gaussian (LQG); and (4) Variable Structure System (VSS). The designs are required to achieve good ride quality and road handling, as well as the classical passive suspension trade-offs. New computer-aided design (CAD) methods, based on automatic control theory, are proposed. The corresponding controllers dramatically improve car behaviour in terms of occupants' comfort and security. The paper describes in some detail: (1) the mathematical model used; (2) the control problem of automotive suspension; (3) the design of the controllers; and (4) the simulation results. The efficiency of the approaches and the performances of the controllers are compared with the results of various alternative approaches. Finally, some comments are made on technology and implementation. For the covering abstract see IRRD 870290.
Optical biosensor technologies for molecular diagnostics at the point-of-care (2015)

Label-free optical schemes for molecular biosensing hold a strong promise for point-of-care applications in medical research and diagnostics. Apart from diagnostic requirements in terms of sensitivity, specificity, and multiplexing capability, also other aspects such as ease of use and manufacturability have to be considered in order to pave the way to a practical implementation. We present integrated optical waveguide as well as magnetic nanoparticle based molecular biosensor concepts that address these aspects. The integrated optical waveguide devices are based on low-loss photonic wires made of silicon nitride deposited by a CMOS compatible plasma-enhanced chemical vapor deposition (PECVD) process that allows for backend integration of waveguides on optoelectronic CMOS chips. The molecular detection principle relies on evanescent wave sensing in the 0.85 μm wavelength regime by means of Mach-Zehnder interferometers, which enables on-chip integration of silicon photodiodes and, thus, the realization of system-on-chip solutions. Our nanoparticle-based approach is based on optical observation of the dynamic response of functionalized magneticcore/ noble-metal-shell nanorods (‘nanoprobes’) to an externally applied time-varying magnetic field. As target molecules specifically bind to the surface of the nanoprobes, the observed dynamics of the nanoprobes changes, and the concentration of target molecules in the sample solution can be quantified. This approach is suitable for dynamic real-time measurements and only requires minimal sample preparation, thus presenting a highly promising point-of-care diagnostic system. In this paper, we present a prototype of a diagnostic device suitable for highly automated sample analysis by our nanoparticle-based approach.
O, K, and H Antigens Predict Virulence Factors, Carboxylesterase B Pattern, Antimicrobial Resistance, and Host Compromise among Escherichia coli Strains Causing Urosepsis (1994)

The O:K:H serotypes of 75 Escherichia coli blood isolates from patients with urosepsis were compared for the presence and expression of determinants for P fimbriae, hemolysin, and aerobactin; antimicrobial resistance; the carboxylesterase B phenotype; and associated compromising host conditions. O groups, K types, and O:K:H serotypes previously associated with urovirulence accounted for 69%, 60%, and 31% of the population, respectively. Chromosomal determinants for P fimbriae, hemolysin, and aerobactin were present in combination more commonly among strains belonging to urovirulence-associated O groups, K types, and O:K:H serotypes. Similarly, antimicrobial resistance was strikingly less prevalent, the B2 carboxylesterase phenotype more common, and associated host compromise less common among such strains. These data demonstrate that the O groups, K types, and O:K:H serotypes traditionally associated with urovirulence are prominent among E. coli strains causing urosepsis, in which they are associated with presence and expression of multiple chromosomal virulence factor determinants, susceptibility to antimicrobial agents, the B2 carboxylesterase phenotype, and noncompromised hosts.
Assessment of Hospice Nurses' Technique in the Use of Inhalers and Nebulizers (2007)

Dyspnea, a common distressing end-of-life symptom, is treated with oral (i.e., opioids and anxiolytics) and inhaled medications (anti-inflammatory and bronchodilator agents). Health care providers and patients have demonstrated an inability to use inhaler devices correctly, which can lead to suboptimal drug delivery and poor symptom relief. Hospice nurses are the primary health care providers educating patients, making it critical that they convey accurate device technique. This study assessed hospice nurses' ability to demonstrate proper inhaler device technique and their knowledge of agents used to treat dyspnea. Forty-seven nurses participated. Participants completed a written questionnaire, which gathered demographic data, as well as information regarding previous training with an inhaler device, administration, pharmacokinetics, mechanism of action, patient assessment, and nursing technique. Additionally, each nurse demonstrated the use of a metered dose inhaler, spacer, dry powder inhaler, and a nebulizer, while being observed by a pharmacist trained in the use of inhalers. A standardized evaluation form was used to ensure consistency between evaluators and subjects. Percentage of steps completed correctly by the study participants ranged from 34.9% with the dry powder inhaler to 67.6% with the metered dose inhaler. Years of experience, presence of hospice certification, personal use of inhaler, and nursing comfort level significantly impacted ability to use inhalation devices. This study demonstrated the existence of knowledge gaps regarding patient assessment, pharmacology and pharmacokinetics of inhaled medications, and inhalation device technique among hospice nurses. Formal education of hospice practitioners regarding inhaled medications and inhalation delivery devices is needed.