gebhart/patrepeval huggingface dataset:
Improvement on Brook theorem for (3 Times K1)-free Graphs (2017)

Problem of finding an optimal upper bound for the chromatic no. of a (3 Times K1)-free graph is still open and pretty hard. Here we prove that for a (3 Times K1)-free graph G with maximum degree greater than or equal to 8, χ is less than or equal to max (maximum degree-1, ω). We also prove that if G is (3 Times K1)-free, ω is equal to 4 and maximum degree is greater than or equal to 7, then χ is less than or equal to maximum degree-1. This implies that Borodin &amp; Kostochka Conjecture is true for (3 Times K1)-free graphs as a corollary.
Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity (2019)

AAV vectors poorly transduce Dendritic cells (DC), a feature invoked to explain AAV's low immunogenicity. However, the reason for this non-permissiveness remained elusive. Here, we performed an in-depth analysis using human monocyte-derived immature DC (iDC) as model. iDC internalized AAV vectors of various serotypes, but even the most efficient serotype failed to transduce iDC above background. Since AAV vectors reached the cell nucleus, we hypothesized that AAV's intracellular processing occurs suboptimal. On this basis, we screened an AAV peptide display library for capsid variants more suitable for DC transduction and identified the I/VSS family which transduced DC with efficiencies of up to 38%. This property correlated with an improved vector uncoating. To determine the consequence of this novel feature for AAV's in vivo performance, we engineered one of the lead candidates to express a cytoplasmic form of ovalbumin, a highly immunogenic model antigen, and assayed transduction efficiency as well as immunogenicity. The capsid variant clearly outperformed the parental serotype in muscle transduction and in inducing antigen-specific humoral and T cell responses as well as anti-capsid CD8<sup>+</sup> T cells. Hence, vector uncoating represents a major barrier hampering AAV vector-mediated transduction of DC and impacts on its use as vaccine platform.
Abstract 3725: Myocardial Microvascular Obstruction in Sudden Death from Acute Myocardial Infarction Occurs more often in Coronary Plaque Erosion than in Plaque Rupture (2008)

Epicardial coronary artery thrombosis is associated with myocardial microvascular obstruction (MVO) and microemboli. Clinical consequences include acute myocardial infarction and sudden cardiac death from myocardial MVO and myocyte necrosis. We thus characterized myocardial histopathology and morphometry and related these findings to epicardial coronary artery plaque in patients dying from coronary artery occlusion. Hearts from patients with proven sudden coronary death from acute coronary artery occlusion underwent histopathologic characterization for MVO, cardiac microemboli, and epicardial coronary artery plaque. Immunohistochemistry was performed on microvascular thrombus to evaluate for platelet and fibrin content. Forty four cases were studied (mean age at death 51 ± 15 yrs). All emboli and MVO thrombus stained for both fibrin and platelets, and occurred in 54% of all patients, mean 4.5 microemboli/heart. Of all occluded microvessels, 89% were less than 120 um diameter (39% were &lt; 30 um dia), and only 4% were greater than 200 um diameter. Microvascular obstruction and emboli occurred more often in epicardial plaque erosion (74% vs 40% of cases with MVO), and was most common in the LAD territory. Histopathologic epicardial coronary stenosis severity was (mean) 74% in those with emboli and 75% in those without (p=ns). Microemboli and microvascular obstruction are very common in patients dying of acute coronary artery thrombosis. Plaque erosion may be most likely to cause such emboli, with accumulation in sub-200 micron vessels. These emboli and microvessel obstruction have a prominent clinical role due to associated myonecrosis. Interventional strategies for eliminating MVO may be useful to limit myocardial damage and prevent long term sequelae.
Antimicrobial peptide, tachyplesin I, isolated from hemocytes of the horseshoe crab (Tachypleus tridentatus). NMR determination of the beta-sheet structure. (1990)

The conformation of tachyplesin I, an antimicrobial cationic peptide of 17 residues found in the hemocyte debris of horseshoe crab, was investigated using two-dimensional NMR spectroscopy. The 1H NMR spectrum of tachyplesin I in aqueous solution could be completely assigned, and the secondary structure was substantiated by interpretation of the nuclear Overhauser effect, coupling constant, amide exchange rate, and temperature dependence of the amide chemical shift. Tachyplesin I takes on a fairly rigid conformation constrained by two disulfide bridges and adopts a conformation consisting of an anti-parallel beta-sheet (residues 3-8 and 11-16) connected by a beta-turn (residues 8-11). In this planar conformation, five bulky hydrophobic side groups are localized in one side of the plane and six cationic side groups are distributed at the "tail" part of the molecule (residues 1-5 and 14-17). This amphipathic structure of the molecule is presumed to be closely associated with the bactericidal activity.
DOMINO: a database of domain-peptide interactions (2006)

Many protein interactions are mediated by small protein modules binding to short linear peptides. DOMINO (http://mint.bio.uniroma2.it/domino/) is an open-access database comprising more than 3900 annotated experiments describing interactions mediated by protein-interaction domains. DOMINO can be searched with a versatile search tool and the interaction networks can be visualized with a convenient graphic display applet that explicitly identifies the domains/sites involved in the interactions.
Quality based frame selection for video face recognition (2012)

Quality based frame selection is a crucial task in video face recognition, to both improve the recognition rate and to reduce the computational cost. In this paper we present a framework that uses a variety of cues (face symmetry, sharpness, contrast, closeness of mouth, brightness and openness of the eye) to select the highest quality facial images available in a video sequence for recognition. Normalized feature scores are fused using a neural network and frames with high quality scores are used in a Local Gabor Binary Pattern Histogram Sequence based face recognition system. Experiments on the Honda/UCSD database shows that the proposed method selects the best quality face images in the video sequence, resulting in improved recognition performance.
Interplay of octahedral rotations and breathing distortions in charge-ordering perovskite oxides (2013)

We investigate the structure-property relationships in $AB$O${}_{3}$ perovskites exhibiting octahedral rotations and cooperative octahedral breathing distortions (CBD) using group theoretical methods. Rotations of octahedra are ubiquitous in the perovskite family, while the appearance of breathing distortions---oxygen displacement patterns that lead to approximately uniform dilation and contraction of the $B$O${}_{6}$ octahedra---are rarer in compositions with a single, chemically unique $B$ site. The presence of a CBD relies on electronic instabilities of the $B$-site cations, either orbital degeneracies or valence-state fluctuations, and often appear concomitant with charge order metal-insulator transitions or $B$-site cation ordering. We enumerate the structural variants obtained from rotational and breathing lattice modes and formulate a general Landau functional describing their interaction. We use this information and combine it with statistical correlation techniques to evaluate the role of atomic scale distortions on the critical temperatures in representative charge ordering nickelate and bismuthate perovskites. Our results provide microscopic insights into the underlying structure-property interactions across electronic and magnetic phase boundaries, suggesting plausible routes to tailor the behavior of functional oxides by design.
Effect of Dermoscopy Education on the Ability of Medical Students to Detect Skin Cancer (2012)

Students receiving the dermoscopy tutorial improve in diagnosis of cutaneous lesions compared with those not receiving the dermoscopy intervention. Teaching SCE with inclusion of dermoscopy may be an effective means of enhancing skin cancer knowledge.
Model of the Evaporating Meniscus in a Capillary Tube (1992)

A mathematical model describing the evaporating meniscus in a capillary tube has been formulated incorporating the full three-dimensional Young–Laplace equation, Marangoni convection, London–van der Waals dispersion forces, and nonequilibrium interface conditions. The results showed that varying the dimensionless superheat had no apparent effect on the meniscus profile. However, varying the dispersion number produced a noticeable change in the meniscus profile, but only at the microscopic level near the tube wall. No change in the apparent contact angle was observed with changes in the dimensionless superheat or dispersion number. In all cases, the dimensionless mean curvature was asymptotic to a value equal to that for a hemispherical meniscus. The local interfacial mass flux and total mass transfer rate increased dramatically as the dispersion number was increased, suggesting that surface coatings can play an important role in improving or degrading capillary pumping. The model also predicted that the local capillary pressure remains constant and equal to 2σ/rc regardless of changes in the dimensionless superheat and dispersion number. It should be noted that the results in this study are theoretical in nature and require experimental verification.
Synthesis and chemistry of the insect antifeedant azadirachtin (1994)

Abstract
D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase (2013)

d-Serine is an endogenous ligand for NMDARs generated from l-serine by the enzyme serine racemase (Srr). Both neuronal and glial localizations have been reported for d-serine and Srr. 3-Phosphoglycerate dehydrogenase is an exclusively astrocytic enzyme that catalyzes the first committed step of l-serine biosynthesis. Using transgenic mice expressing enhanced green fluorescent protein under the Srr promoter and mice with targeted deletion of Srr or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine. These findings clarify the cellular basis for the regulation of NMDAR neurotransmission by d-serine.
Space harmonics analysis of the main air gap flux of an induction motor and its applicability to detect faults (2014)

Condition monitoring of an induction motor may be based on measuring the electrical signals, such as stator current, electromagnetic flux etc. or mechanical signals such as vibration, noise etc. from the motor. Most of the existing electrical techniques of condition monitoring and fault diagnostics are based on the stator current and/or leakage flux measurement outside the motor. Besides, most of these methods only concentrate on the time harmonics analysis of the acquired signal. But the main air gap flux consists of both time and space harmonics. The latter is overlooked by most of the existing researches. We propose to analyse the space harmonics of the main air gap electromagnetic flux along with the time domain analysis. But to do so, a thorough knowledge of the space harmonics of the stator flux, the rotor flux and their insights is needed to be obtained. To this aim, we present the space harmonics analysis of the main air gap flux of a healthy induction in this paper. Then the applicability of the space harmonics analysis to detect the faults is discussed. Two types of rotor faults, i.e. eccentricity and the broken rotor bar fault are discussed.
A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity (2020)

Malaria is a global health concern, and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85-Å resolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity and the unusual utilization of an antibody N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites and lack of sporozoite inhibition in vitro and in vivo. Overall, our data do not support the inclusion of the 5D5 N-CSP epitope into the next generation of CSP-based vaccines.
Double-uniform Schottky diode nonlinear transmission line generating sub-picosecond transients (2018)

We report a double-uniform Schottky diode nonlinear transmission line on gallium arsenide generating a sub-picosecond 7.2 volt transient, doubling the amplitude of the earlier record result. Our optimized diode structure provides both high cut-off frequency, high current saturation limit, and 2:1 capacitance modulation over 8 volts. Current saturation becomes a limiting factor for ultrafast waveforms when the diffusion current through the capacitive depletion region exceeds the current carrying capacity of the unde-pleted resistive region. This work highlights a critical design parameter for frequency generating diodes, providing the ground work for large power increases in ultrafast diode-based circuits.
Apoplastic Alkalinization Is Instrumental for the Inhibition of Cell Elongation in the Arabidopsis Root by the Ethylene Precursor 1-Aminocyclopropane-1-Carboxylic Acid (2011)

In Arabidopsis (Arabidopsis thaliana; Columbia-0) roots, the so-called zone of cell elongation comprises two clearly different domains: the transition zone, a postmeristematic region (approximately 200-450 μm proximal of the root tip) with a low rate of elongation, and a fast elongation zone, the adjacent proximal region (450 μm away from the root tip up to the first root hair) with a high rate of elongation. In this study, the surface pH was measured in both zones using the microelectrode ion flux estimation technique. The surface pH is highest in the apical part of the transition zone and is lowest at the basal part of the fast elongation zone. Fast cell elongation is inhibited within minutes by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid; concomitantly, apoplastic alkalinization occurs in the affected root zone. Fusicoccin, an activator of the plasma membrane H(+)-ATPase, can partially rescue this inhibition of cell elongation, whereas the inhibitor N,N'-dicyclohexylcarbodiimide does not further reduce the maximal cell length. Microelectrode ion flux estimation experiments with auxin mutants lead to the final conclusion that control of the activity state of plasma membrane H(+)-ATPases is one of the mechanisms by which ethylene, via auxin, affects the final cell length in the root.
Plan Execution, Monitoring, and Adaptation for Planetary Rovers. (2000)

Planetary rovers must perform their missions in unknown environments with limited communication to ground controllers. To endow a rover with the capability for robust autonomous operation, we have designed an on-board executive architecture that incorporates robust flexible operation, monitoring of system and environmental state, and limited plan adaptation. The rover executive receives a plan with flexible time and resource contraints along with local and global contingency plans to handle deviations from the nominal plan. It internally monitors plan execution for communication and execution failures; through sensors and models of its operation it determines its internal state, its resource usage, and its interaction with respect to the environment. Based on the information it gathers from the sonsors, it chooses the most appropriate course of action, potentially inserting contingency plans into its current plan, thus adapting its plan to fit the current situation.
Preparation of 2‐(2‐(Dicyclohexylphosphino)phenyl)‐1‐methyl‐1 H ‐indole ( CM ‐phos) (2017)

Abstract The article describes the preparation of 2‐(2‐(Dicyclohexylphosphino)phenyl)‐1‐methyl‐1 H ‐indole (CM‐phos).We selected the Fischer indole synthesis as our primary tool to synthesize the indole templates from phenylhydrazine and 2’‐bromoacetophenone. With the methylated ligand precursor, CM‐phos could be afforded easily by lithiation and subsequently trapping with chlorodicyclohexylphosphine. It should be noted that CM‐phos in combination with the precatalyst palladium(II) acetate is highly active and effective in amination and Suzuki cross‐coupling reaction of aryl mesylates.
One-year clinical outcomes of the STENTYS Self-Apposing¨ coronary stent in patients presenting with ST-segment elevation myocardial infarction: results from the APPOSITION III registry (2015)

The use of the STENTYS Self-Apposing¨ stent in the setting of primary PCI was feasible and associated with acceptable cardiovascular event rates which improved when post-dilation was performed.
Supplementary materials from Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth (2023)

&lt;p&gt;Table S1. UV calibration line parameters for BMMPI quantification. Figure S1. MMP-2 expression in murine and human breast cancer cell lines and BMMPI structure. Figure S2. Selective MMP-2 inhibition by the BMMPIs ML104 and ML115. Figure S3. Impact of BMMPIs on 4T1 bone metastatic breast cancer growth and osteolysis. Figure S4. ML115 is rapidly cleared from the plasma and accumulates in the bone marrow microenvironment over time. effects.Figure S5. The addition of exogenous TGFβ protects breasts cancer cells from BMMPI&lt;/p&gt;
Data from Systemic Immune Activity Predicts Overall Survival in Treatment-Naïve Patients with Metastatic Pancreatic Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate &lt;7% and is ultimately refractory to most treatments. To date, an assessment of immunologic factors relevant to disease has not been comprehensively performed for treatment-naïve patients. We hypothesized that systemic immunologic biomarkers could predict overall survival (OS) in treatment-naïve PDAC patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Peripheral blood was collected from 73 patients presenting with previously untreated metastatic PDAC. Extensive immunologic profiling was conducted to assess relationships between OS and the level of soluble plasma biomarkers or detailed immune cell phenotypes as measured by flow cytometry.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Higher baseline levels of the immunosuppressive cytokines IL6 and IL10 were strongly associated with poorer OS (&lt;i&gt;P&lt;/i&gt; = 0.008 and 0.026, respectively; HR = 1.16 and 1.28, respectively), whereas higher levels of the monocyte chemoattractant MCP-1 were associated with significantly longer OS (&lt;i&gt;P&lt;/i&gt; = 0.045; HR = 0.69). Patients with a greater proportion of antigen-experienced T cells (CD45RO&lt;sup&gt;+&lt;/sup&gt;) had longer OS (CD4 &lt;i&gt;P&lt;/i&gt; = 0.032; CD8 &lt;i&gt;P&lt;/i&gt; = 0.036; HR = 0.36 and 0.61, respectively). Although greater expression of the T-cell checkpoint molecule CTLA-4 on CD8&lt;sup&gt;+&lt;/sup&gt; T cells was associated with significantly shorter OS (&lt;i&gt;P&lt;/i&gt; = 0.020; HR = 1.53), the TIM3 molecule had a positive association with survival when expressed on CD4&lt;sup&gt;+&lt;/sup&gt; T cells (&lt;i&gt;P&lt;/i&gt; = 0.046; HR = 0.62).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These data support the hypothesis that baseline immune status predicts PDAC disease course and overall patient survival. To our knowledge, this work represents the largest cohort and most comprehensive immune profiling of treatment-naïve metastatic PDAC patients to date. &lt;i&gt;Clin Cancer Res; 22(10); 2565–74. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Removal of Mercury by Emulsion Liquid Membranes: Studies on Emulsion Stability and Scale Up (2013)

Abstract Emulsion liquid membranes (ELM) have received significant attention in the separation of various metal ions from industrial wastewater. Still efforts are needed to get the desired level of stability to overcome the hindrance in the application of ELM at industrial scale. In this paper, the effects of various parameters such as emulsification speed, concentration of cosurfactant, surfactant, carrier and impeller speed during extraction on the stability of an emulsion liquid membrane are studied. Dispersion destabilization of w/o emulsion is checked by Turbiscan. Drop size distribution and photomicrographs of the emulsions are also analyzed to evaluate stability of the emulsion. Instability of emulsion liquid membrane during extraction process is measured in terms of membrane breakage. A stable emulsion is used for the extraction of mercury from aqueous solution in small scale as well as in large scale. Keywords: Cosurfactantemulsion liquid membranemembrane breakagemembrane swellingmercury extraction Notes a D = Tank diameter. b d = Impeller diameter. c H = Height of the tank.
Artificial Intelligence in PET: an Industry Perspective (2021)

Artificial intelligence (AI) has significant potential to positively impact and advance medical imaging, including positron emission tomography (PET) imaging applications. AI has the ability to enhance and optimize all aspects of the PET imaging chain from patient scheduling, patient setup, protocoling, data acquisition, detector signal processing, reconstruction, image processing and interpretation. AI poses industry-specific challenges which will need to be addressed and overcome to maximize the future potentials of AI in PET. This paper provides an overview of these industry-specific challenges for the development, standardization, commercialization, and clinical adoption of AI, and explores the potential enhancements to PET imaging brought on by AI in the near future. In particular, the combination of on-demand image reconstruction, AI, and custom designed data processing workflows may open new possibilities for innovation which would positively impact the industry and ultimately patients.