gebhart/patrepeval huggingface dataset:
Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint (2022)

Excessive collagen deposition by fibroblasts surrounding some tumors has seriously limited the efficacy of checkpoint inhibitor therapies. Chen et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210693) show that IL-17 promotes collagen deposition by cancer-associated fibroblasts, enhancing immune exclusion of tumors, and that targeting IL-17-triggered HIF1α expression can reverse matrix mediated immune exclusion.
multiplierz v2.0: A Python‐based ecosystem for shared access and analysis of native mass spectrometry data (2017)

The continued evolution of modern mass spectrometry instrumentation and associated methods represents a critical component in efforts to decipher the molecular mechanisms which underlie normal physiology and understand how dysregulation of biological pathways contributes to human disease. The increasing scale of these experiments combined with the technological diversity of mass spectrometers presents several challenges for community-wide data access, analysis, and distribution. Here we detail a redesigned version of multiplierz, our Python software library which leverages our common application programming interface (mzAPI) for analysis and distribution of proteomic data. New features include support for a wider range of native mass spectrometry file types, interfaces to additional database search engines, compatibility with new reporting formats, and high-level tools to perform post-search proteomic analyses. A GUI desktop environment, mzDesktop, provides access to multiplierz functionality through a user friendly interface. multiplierz is available for download from: https://github.com/BlaisProteomics/multiplierz; and mzDesktop is available for download from: https://sourceforge.net/projects/multiplierz/.
Growth of Healthy Term Infants Fed Partially Hydrolyzed Whey-Based Infant Formula (2014)

Partially hydrolyzed formulas (pHF) represent a significant percentage of the infant formula market. A new whey-based, palm olein oil (PO)-free pHF was developed and a masked, randomized, parallel growth study was conducted in infants fed this formula or a commercially available whey-based pHF with PO. Infants between 0 and 8 days were to be enrolled and studied to 119 days of age. Growth and tolerance of infants were evaluated. Mean weight gain from 14 to 119 days of age was similar between groups. There were no significant differences between groups in weight, length, head circumference (HC), or length or HC gains. Infants fed the new PO-free pHF had significantly softer stools than those fed the PO-containing formula except at 119 days of age. This study demonstrates that whereas growth of infants fed different formulas during the first 4 months of life may be similar, infants may tolerate individual formulas differently.
Context activity selection and scheduling in context-driven simulation (2014)

Human activities in smart spaces are traced by sensors and logged, as sensor events, in the form of sensory values, when the sensors detect elements of the activities. The event-driven approach that models the combination of the sensor events is one of the most common human activity simulation approaches. However, this approach is scale-wise challenged as activities and spaces get more complex. A large volume of sensor events demands more human efforts in modeling, and requires higher processing overhead. We observe that rather than simulating by combining sensor events, semantical abstraction could offer a scalable alternative in managing such complexity. In our previous work, we proposed a context-driven such an approach, which scales well in complex simulation. The approach evaluates current state space and advances the simulation loop by units of context, not by sensor events. By changing the domain of simulation from event to context, we could measure a remarkable performance advantage. Through the experiment, we noticed that activity design was critical to end performance. In this paper, therefore, we focus on modeling activities for a better fit to the context-driven approach. We introduce a new activity model along with associated algorithms to select and schedule the activities. We also provide an evaluation of the performance and computational complexity of the algorithms.
Validation of breath biomarkers for obstructive sleep apnea (2021)

"Mass Spectral Fingerprinting in Obstructive Sleep Apnoea", NCT02810158, www.ClinicalTrials.gov.
Cyclopropanes from an Easily Prepared, Highly Active Zinc—Copper Couple, Dibromomethane, and Olefins (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopropanes from an Easily Prepared, Highly Active Zinc—Copper Couple, Dibromomethane, and OlefinsEugene LeGoffCite this: J. Org. Chem. 1964, 29, 7, 2048–2050Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/jo01030a529https://doi.org/10.1021/jo01030a529research-articleACS PublicationsRequest reuse permissionsArticle Views2518Altmetric-Citations202LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma Growth Hormone Is Elevated Immediately after Resistance Exercise with Electrical Stimulation and Voluntary Muscle Contraction (2010)

Resistance exercise is a physiological stimulus for acute increases in growth hormone (GH) secretion, and it also causes lactate accumulation and stimulates norepinephrine (NE) secretion as a sympathetic nervous response. The hybrid exercise method (HYB) is a novel resistance exercise method that combines a voluntary concentric muscle contraction and an electrically stimulated eccentric muscle contraction. This study was designed to compare the hormonal responses of HYB with typical weight training (WT), as regards GH, lactate, and NE. Twenty-four healthy male subjects (20-27 years) were divided into the HYB group and the WT group. All the subjects performed bilateral leg exercises with 10 sets of 10 reciprocal 2-second (45 degrees /sec) knee flexion-and-extension contractions, and with 1-min interset rest intervals. Plasma concentrations of GH, lactate, and NE were determined before exercise and immediately after exercise (0 min) as well as at 15, 30, 60, and 120 min. The plasma concentrations of GH and lactate were significantly increased immediately after HYB or WT (P < 0.05). Moreover, the degree of the increases of GH and lactate after HYB was significantly higher than that after WT (P < 0.05). The plasma concentration of NE was significantly increased after HYB or WT (P < 0.01), but no significant difference was observed between the two groups. These results indicate that HYB is more efficient in stimulating acute increases in plasma GH and lactate without enhancing sympathetic nerve stimulation, compared to WT. Therefore, HYB may be an effective countermeasure to muscle disuse associated with bed rest or spaceflight.
Signal integrity issues in high-speed wireline links: analysis and integrated system solutions (2006)

This work focuses on the basic signal integrity issues of high-speed wireline links. It bridges the gap between optimum system design and circuit design for such links by: (1) understanding the effects of the system parameters on the bit error rate (BER), (2) introducing circuit architectures for the realization of systems that minimize the BER, and (3) demonstrating integrated circuit prototypes that verify the solutions. First, we develop a theory that analytically relates the data link BER to the system characteristics, e.g., the channel response, the pre-amplifier bandwidth, and the transmitter clock jitter. We generate the BER contours to find the optimum receiver bandwidth as well as the optimum sampling point and its associated timing margin. We also develop the theory of the data-dependent jitter (DDJ), which is a significant component of the timing jitter in high-speed links. We provide an analytical distribution function for the DDJ of an arbitrary linear time-invariant system and include the impact of the DDJ on the BER. Second, we propose a bandwidth enhancement method for wideband amplifiers. This is useful for the realization of high-speed links in technologies that suffer from large parasitic components. The method leverages two-port broadband matching to enable amplifier stages to achieve their maximum gain-bandwidth product. We demonstrate a 10Gb/s CMOS 0.18um amplifier with this technique that has 2.4 times the bandwidth improvement over a design that does not apply the technique. Third, we develop an eye-opening monitor (EOM) that enables full integration of adaptive equalizers. The EOM evaluates the signal eye diagram quality and reports a quantitative measure, which is correlated to the signal integrity. We demonstrate a prototype in 0.13um standard CMOS that operates up to 12.5Gb/s and has 68dB error dynamic range. Finally, we introduce an instantaneous clockless demultiplexer for burst-mode communication applications. We propose a clockless finite state machine that recovers and demultiplexes the received burst of data instantaneously. The architecture consists of a combinational logic structure and a bit-period-delayed feedback loop. We demonstrate a 1:2 clockless demultiplexer based on this concept in SiGe BiCMOS technology that operates at 7.5Gb/s.
A Method to Provide Conditions for Sustained Excitation (2018)

For the linear regression model, the problem of relaxing conditions for sustained excitation in the problems of estimation of the unknown constant parameters of the model was discussed. An approach was suggested enabling one to form from a damped regressor a new signal for which the conditions of sustained excitation are satisfied. The cases of one and two unknown parameters giving one an insight into the root idea of the proposed approach were analyzed in detail. Operability of the algorithms considered in the paper was illustrated by computer-aided modeling.
Quantum Euler-Manakov top on the three-sphere S3 (1991)

The authors construct the harmonic polynomials on the real S3-sphere associated with the separation of the Laplace operator in general ellipsoid coordinates. They describe a basis of an irreducible unitary representation of the o(4) Lie algebra coming from the quantum integrable system: the Euler-Manakov top on the 3-sphere S3 or, equivalently, a two-site su(2) XYZ Gaudin magnet. An isomorphism of this model with the four-site su(1, 1) XXX Gaudin magnet is established. The final two-parameter spectral problem is efficiently solved.
IP Switching and Routing Essentials: Understanding RIP, OSPF, BGP, MPLS, CR-LDP, and RSVP-TE (2002)

Introduction. IP--The Internet Protocol. Transport Protocols--An Overview of TCP and UDP. Link State Routing and OSPF. Distance Vector Routing and RIP. Path Vector Routing and BGP. MPLS--Multi--Protocol Label Switching. LDP--Label Distribution Protocol. RSVP--TE--Resource Reservation for Traffic Engineering. Glossary.Index.
Mean and fluctuating velocity fields of a diamond turbulent jet (2013)

The present paper reports the first investigation on a turbulent jet issuing from a diamond orifice (hereafter termed a "diamond jet") with an aspect ratio of 1.7. Velocity measurements were conducted in the transitional region, and the exit Reynolds number of the jet was 50000. For comparison, a round jet with identical normalized boundary conditions was also measured. It is shown that the diamond jet decays and spreads faster than the round jet does over the measured flow region. The axis-switching phenomenon is observed in the diamond jet. Although both jets display primary coherent structures in the near field, these structures are found to break down more rapidly in the diamond jet, due to the higher three-dimensionality of the flow. Moreover, the streamwise components of the Reynolds normal stress and all the shear stresses reach their maxima around the location of the maximal mean shear while the maxima of the lateral components of the Reynolds normal stresses occur around the centreline of the jet.
Automation of screening device for cancer cell-specific binding peptides using spheroids (2019)

This study develops a microfluidic device for screening for cancer cell-specific binding peptides targeting spheroids. The goal of this study is the full automation of the screening device. The washing process of the screening involves multiple executions of liquid drain, merge with a dilution solution and mixture. In this paper, we propose a flow path design and a control system for position/speed control of a droplet containing spheroids and peptides to achieve the washing process. Preliminary experiments are conducted to validate the proposed flow path design and the control system.
Modulation of SARS-CoV-2 Spike-induced Unfolded Protein Response (UPR) in HEK293T cells by selected small chemical molecules (2021)

Abstract Coronaviruses (CoV) exploits the endoplasmic reticulum (ER) of the host cells for replication and in doing so, increases ER stress. evokes Unfolded Protein Response (UPR) and possibly autophagy, which could all attribute to the pathophysiology of the viral infections. To date, little is known about the roles of ER stress, UPR, and autophagy in SARS-CoV-2 infection. Here we over-expressed the viral Spike (S) protein in cultured HEK293T cells, as it has been shown that such protein is largely responsible for UPR activation in other CoV-infected cells. We noticed, in the transfected cells, heightened ER stress, activation of the PERK-eIF2α arm of the UPR, induction of autophagy and cell death. When we treated the transfected cells with Tauroursodeoxycholic acid (TUDCA), 4-phenyl butyric acid (PBA), Salubrinal, Trazadone hydrochloride, and Dibenzoylmethane (DBM), we saw reduced the BiP/GRP78 levels, but only PBA and TUDCA could significantly diminish the levels of peIF2α and autophagy expression.
Polyelectrolyte multilayer-like films from layer-by-layer processing of protected polyampholytic block copolymers (2018)

Polyelectrolyte multilayer films (PEMs) are conventionally prepared by a layer-by-layer (LbL) deposition of alternating polycation and polyanion solutions. We introduce herein a block copolymer (BCP) approach employing a BCP with an H-bond acceptor block and a protected H-donor block as a masked polyampholyte to form new types of PEMs.
COLLABORATING GLOBALLY : CULTURE AND ORGANIZATIONAL COMPUTER -MEDIATED COMMUNICATION (2011)

Culture shapes interpersonal communication. However, little is known about how culture interacts with computer-mediated communication (CMC) tools in a business context. We present a large-scale empirical study of cultural differences in computer mediated social interactions in a global company. Our dataset includes 9,000 volunteer users and more than 20 million records of their email and Instant Messaging conversations. We compared social network characteristics, preferences for CMC tools, and expression of sentiment across employees working in seven countries. Significant differences emerged and the patterns are consistent with the inherent cultural characteristics as suggested by cultural theories. In addition, we uncover the complex manner in which culture interacts with preference and use of different communication mediums. The existence of pervasive and complex cultural differences, points to the need to understand and account for such differences in designing cross-cultural collaborative systems.
Statistical Comparison of High-Shear Versus Low-Shear Granulation Using a Common Formulation (2000)

Experimental combinations from the ranges assigned to the independent factors were studied using both a low-shear (planetary) mixer and a high-shear mixer for granulation. The independent factors studied were X1 calcium phosphate/mannitol ratio, X2 pregelatinized starch, X3 magnesium stearate, X4 mixer type, and X5 compression pressure. To optimize the tablet properties fully, the experimental range was varied from -2 to +2 experimental units, with the exception of X4, which was assigned -1 for the planetary mixer and +1 for the high-shear mixer. Drug dissolution did not seem to be affected by mixer type, but tablet hardness was affected by mixer type.
Phase Improvement by Multi-Start Simulated Annealing Refinement and Structure-Factor Averaging (1998)

Macromolecular crystallography increasingly pushes the limits of the size and complexity of the molecules and assemblies under study. Conformational variability in these assemblies frequently results in limited diffraction or in poorer phase information than that typically obtained from smaller macromolecules. Current methods for solving and refining crystal structures often perform poorly under these adverse conditions and thus new methods must be developed. Atomic-model refinement is particularly sensitive to the low information content of limited diffraction data. Here a multi-start procedure is presented for simulated annealing refinement. After multi-start refinement, poorly fitted regions of the model often display increased variability compared with correctly fitted regions. Structure-factor averaging over the resulting models improves the quality of phases derived from atomic models and reduces model bias. Averaging can be performed even at a minimum Bragg spacing of 3.5 Å, taking into account variability of atomic positions due to errors or intrinsic flexibility even when individual B factors cannot be refined. The average structure factor is thus closer to the true structure factor and should provide a better starting point for estimations of σ A values for electron-density-map calculations. Test cases show increased phase quality of the average structure factor. The method is most useful when the initial model is poor or when only moderate-resolution diffraction data are available and may allow meaningful phase improvement through atomic-model refinement where it was not previously possible.
Vitalising porous inorganic silica networks with organic functions—PMOs and related hybrid materials (2010)

Mesoporous organic-inorganic hybrid materials are an interesting class of materials, which combine the advantages of two worlds; the inorganic part builds a robust substrate while organic functions make them alive in a way that they can be potentially used in a number of applications. In this tutorial review, we provide an overview of how mesoporous materials are synthesised via the 'soft template' path and how the incorporation of organic functions can be achieved. Furthermore, a colourful survey full of examples is presented, providing a small overview of field of applications that can potentially benefit from the use of periodic mesoporous organosilicas (PMOs) and related materials.
3H-Thymidine Incorporation into Nuclear DNA of Leaf Cells (1967)

The incorporation of (3)H-thymidine into nuclear DNA of leaf cells of Nanthium pennsylvanicum was studied as a function of concentration and specific activity of the radioisotope. From the assessment of the average number of grains per nucleus and the percent of labeled nuclei, it was concluded that the incorporation was a linear function of concentration of the exogenous radioisotopic solution and a logarithmic function of the incubation time. Ten microcuries per milliliter on the average yielded 20% of labeled nuclei with 18 grains per nucleus. Seven-fold increase in concentration only doubled the amount of (3)H-thymidine incorporated. The lamina regions near the vein incorporated a significantly greater amount of the radioisotope than the lamina region at some distance from the vein. The specific activities of 2, 3.35, 6.7 and 15.3 c/mmole had no effect upon the amount of (3)H-thymidine incorporated, if the amount of microcuries of the incubation solution was the same in each activity. Considering the total number of molecules, the estimated rates of incorporation indicated that at the activity of 2 c/mmole, the system operated with about 7 times higher rates as compared with the activity of 15.3 c/mmole.
Endovascular Stent–Graft Placement for the Treatment of Acute Aortic Dissection (1999)

These initial results suggest that stent-graft coverage of the primary entry tear may be a promising new treatment for selected patients with acute aortic dissection. This technique requires further evaluation, however, to assess its therapeutic potential fully.
Thermal anomalies associated with forced and free ground-water convection in the Dead Sea rift valley: Discussion and reply (1999)

Research Article| July 01, 1999 Thermal anomalies associated with forced and free ground-water convection in the Dead Sea rift valley: Discussion and reply Gerald M. Friedman; Gerald M. Friedman 1Department of Geology, Brooklyn College and Graduate School of the City University of New York, Brooklyn, New York 11210, and Northeastern Science Foundation affiliated with Brooklyn College, Rensselaer Center of Applied Geology, 15 Third Street, P.O. Box 746, Troy, New York 12181-0746. Correspondence address: P.O. Box 746, Troy, New York 12181-0746; gmfriedman@juno.com Search for other works by this author on: GSW Google Scholar Haim Gvirtzman; Haim Gvirtzman 3Institute of Earth Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel; haimg@vms.huji.ac.il Search for other works by this author on: GSW Google Scholar Grant Garven; Grant Garven 5Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland 21218 Search for other works by this author on: GSW Google Scholar Gdaliahu Gvirtzman Gdaliahu Gvirtzman 6Department of Geography, Bar Ilan University, Ramat Gan 52900, Israel Search for other works by this author on: GSW Google Scholar GSA Bulletin (1999) 111 (7): 1098–1102. https://doi.org/10.1130/0016-7606(1999)111<1098:TAAWFA>2.3.CO;2 Article history first online: 01 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation Gerald M. Friedman, Haim Gvirtzman, Grant Garven, Gdaliahu Gvirtzman; Thermal anomalies associated with forced and free ground-water convection in the Dead Sea rift valley: Discussion and reply. GSA Bulletin 1999;; 111 (7): 1098–1102. doi: https://doi.org/10.1130/0016-7606(1999)111<1098:TAAWFA>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract No Abstract Available. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.