gebhart/patrepeval huggingface dataset:
Spotting overgeneration suspects (2007)

We present a method for quickly spotting overgeneration suspects (i.e., likely cause of overgeneration) in hand-coded grammars. The method is applied to a medium size Tree Adjoining Grammar (TAG) for French and is shown to help reduce the number of outputs by 70% almost all of it being overgeneration.
Réacteurs à hautes densités cellulaires pour la production de solutions concentrées de bactériocines (1998)

Production of concentrated bacteriocin solutions in high cell density bioreactors. Bacteriocins are natural proteinaceous antimierobial substances produced by mieroorganisms like lactic acid bacteria to dominate the other microflora. Their use in the food industry as natu-raI preservatives is tightly linked to the emergence of efficient and inexpensive production and purification procedures. The production of an anti-Listeria bacteriocin, named Divercin, by Carnobacterium divergens, has been studied in batch, continuous culture and with viabl cells imrnobilized in alginate gel beads retained in a plug flow bioreactor-The.latter system gave the highest volumetrie productivity with more than 10 5 AU L-I h-I , which was one hundred'times the productivity of the batch system. A new simple (two steps) bacteriocin purification method was . developed based on Triton -114 phase partitioning. The pilot production of bacteriocin can then be achieved allowing the exploration of the impact of such additions on the microflora of foodstuffs. InralElsevier, Paris. bacteriocin / immobilized cells / purification / Carnobacterium / Triton X-
URODYNAMIC EFFECTS OF INTRAVESICAL RESINIFERATOXIN IN HUMANS: PRELIMINARY RESULTS IN STABLE AND UNSTABLE DETRUSOR (1997)

Our results suggest that in humans there may be substantial differences in urodynamic effects between resiniferatoxin and capsaicin when the drugs are instilled into the bladder. Further studies, in vitro and in vivo, are necessary to define the pharmacological and clinical effects of resiniferatoxin. Because resiniferatoxin did not produce warm or burning sensations at the suprapubic/urethral level during infusion and seems to have rapid desensitization, it could be an interesting alternative to intravesical capsaicin in the treatment of select cases of bladder hyperactivity.
Quantitative Trait Loci Associated with Resistance to Gray Leaf Spot of Corn (2000)

ABSTRACT The susceptible parent FR1141, the resistant parent 061, the F1 cross, and 301 families selfed once from backcrosses to the susceptible parent were evaluated for gray leaf spot (GLS) severity for two years in Urbana, IL, and one year in Andrews, NC. Linkage between ear height and GLS severity was suspected. Therefore, plant height characteristics were noted for two years in Urbana, IL. Eighty-six polymorphic probes were used to construct a random fragment length polymorphism linkage map, and the presence, locations, effects, and interactions of quantitative trait loci (QTL) associated with GLS, plant and ear height were determined. Five QTL were significantly associated with GLS resistance across all environments and rating periods. These five regions are associated with additive effects on phenotype and account for between 51.0 and 58.7% of the phenotypic variation associated with GLS severity. Additionally, six QTL were identified with maturity-dependent associations to GLS severity. Heritability of GLS resistance was estimated to be approximately 0.73. Four QTL were identified with associations to ear height relative to total plant height. One of the four was associated with higher ear height and GLS resistance.
The Haar measure on a locally compact group (1996)

We have used the term ‘measure’ for any non-negative, additive, set function which vanishes on the empty set [cf. Course on Integration].
Reliable detection of beta-thalassemia and G6PD mutations by a DNA microarray. (2002)

β-Thalassemia is an autosomal recessive disorder caused by the absence or reduction of β-globin chain synthesis. There are >400 million β-thalassemia carriers worldwide, and >160 β-thalassemia mutations have been described (1). Different populations exhibit a specific subset of mutations, as in Sardinia, where carriers are ∼11% of the population and 95% of them present the β 39 mutation (1)(2)(3). In those populations, glucose 6-phosphate dehydrogenase (G6PD) deficiency is also common (4)(5)(6). For the G6PD gene, ∼130 mutations or combinations of mutations have been described (7), and early detection might reduce the risk of hemolytic crisis in childhood. A program of screening newborns would be desirable in those populations. The molecular diagnosis of β-globin and G6PD mutations currently involves a combination of classic methodologies such as restriction fragment length polymorphism analysis, allele-specific oligonucleotide (ASO) hybridization, reverse dot blots, amplification refractory mutation system (ARMS), and direct sequencing (2)(8)(9)(10)(11). These methods are laborious for large-scale screening.

We set up a microarray-based assay for parallel one-shot detection of 17 mutations commonly found in the Mediterranean population: β+ −101(C→T); β+ −87(C→G); β codon 6 (-A); β codon 39 (C→T); β-IVSI-1 (G→A); β+-IVSI-6 (T→C); β+-IVSI-110 (G→A); β-IVSII-1 (G→A); β+-IVSII-745 (C→G); β+-IVSII-844 (C→G); G6PD A− variant (202G→A; 376A→G); Mediterranean variant (563C→T); Seattle variant (844G→C); Montalbano variant (854G→A); S. Antioco variant (1342A→G); and Maewo (1360C→T). We called this microarray “Thalassochip”.

Thalassochip is based on the arrayed primer extension (APEX) technology (12) implemented with allele-specific primed extension (ASPEX) (13). APEX consists of a sequencing reaction primed by an oligonucleotide anchored to a glass slide (with its 5′ end) terminating just one nucleotide before the mutation site. DNA polymerase extends it by adding one fluorescently labeled …
Informing the development of assistive technologies for persons with dementia by connecting financial measures of wealth to perceptions of task dependence (2019)

BACKGROUND: Older adults with dementia have been targeted toward the development of assistive technologies intended to facilitate aging in place. Researchers have documented financial and occupation strain for the caregiver and the financial limitations experienced by persons with dementia. These factors constitute a potential hindrance to the use and applicability of assistive technologies; technologies that may reduce caregiver burden, allow more time for paid work, and, in consequence, reduce occupational strain. OBJECTIVE: To unpack how financial burden, operationalized as direct (e.g., income) and indirect (e.g., caregiver education, employment status) measures of wealth and assets, affect the perceived independence of people with dementia. METHODS: We draw on data collected through a cross-Canada survey of caregivers to develop a set of predictive models of care-recipient task independence. RESULTS: Our findings suggest that said measures of wealth can predict task independence, and more complicated or instrumental daily tasks (e.g., shopping, driving) are perceived as being those with which care recipients need most assistance. CONCLUSIONS: Considering the economical and emotional obstacles that affect both the caregiver and the care recipient, the development of assistive technologies that would be both financially realistic and assistive for this population in these instrumental daily tasks is warranted.
Carbon-13 Nuclear Magnetic Resonance Determination of Monomer Composition and Sequence Distribution in Ethylene-Propylene Copolymers Prepared with a Stereoregular Catalyst System (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 Nuclear Magnetic Resonance Determination of Monomer Composition and Sequence Distribution in Ethylene-Propylene Copolymers Prepared with a Stereoregular Catalyst SystemG. Joseph Ray, Paul E. Johnson, and Jack R. KnoxCite this: Macromolecules 1977, 10, 4, 773–778Publication Date (Print):July 1, 1977Publication History Published online1 May 2002Published inissue 1 July 1977https://pubs.acs.org/doi/10.1021/ma60058a010https://doi.org/10.1021/ma60058a010research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust Estimator for Non-Line-of-Sight Error Mitigation in Indoor Localization (2006)

Indoor localization systems are undoubtedly of interest in many application fields. Like outdoor systems, they suffer from non-line-of-sight (NLOS) errors which hinder their robustness and accuracy. Though many ad hoc techniques have been developed to deal with this problem, unfortunately most of them are not applicable indoors due to the high variability of the environment (movement of furniture and of people, etc.). In this paper, we describe the use of robust regression techniques to detect and reject NLOS measures in a location estimation using multilateration. We show how the least-median-of-squares technique can be used to overcome the effects of NLOS errors, even in environments with little infrastructure, and validate its suitability by comparing it to other methods described in the bibliography. We obtained remarkable results when using it in a real indoor positioning system that works with Bluetooth and ultrasound (BLUPS), even when nearly half the measures suffered from NLOS or other coarse errors.
Coherence Properties of Light in a Dispersive Medium. (1962)

Thesis (Ph.D.)--University of Rochester. Institute of Optics.
Diffusion of Two Potential Anti-HIV Microbicides across Intact and De-Epithelialised, Human Vaginal Mucosa (2008)

The lectins derived from Hippeastrum hybrid ( Hippeastrum hybrid agglutinin, HHA) and from the stinging nettle Urtica dioica (UDA) have been investigated as anti-HIV microbicides. The present study was conducted to determine their diffusion through intact and de-epithelialised human vaginal epithelium. Both lectins were labelled with fluorescein isothiocyanate groups (FITC) and analysed by SDS-polyacrylamide gel electrophoresis. While UDA appeared to be fairly homogeneous with an average Mw of ∼ 8.5 kDa, HHA was a heterogeneous mixture of compounds with Mw's ranging between ∼ 13 and 52 kDa. Fresh human vaginal mucosa was snap-frozen in liquid nitrogen and stored at −85°C. Prior to an experiment, the tissue was defrosted to 20°C in PBS buffer, pH 7.4, and placed in the seven flow cells of a flow-through perfusion apparatus. Either FITC-labelled HHA or UDA was then pipetted into the donor chamber of the flow cell. Samples from each flow cell were collected every 2 hours (1.5 ml/h) over a 24-hour period and analysed by fluorospectrophotometry. Permeability experiments were repeated with vaginal mucosa specimens from which the epithelial layers had been removed by heat-stripping. Both lectins diffused through vaginal mucosa at rates proportionate to their average molecular weights, the flux rates of the smaller UDA being ∼ 5x higher than that of the larger HHA. Removal of the vaginal epithelium increased the flux rates of both HHA and UDA across the mucosa and this may have implications for a more rapid in vivo uptake of these lectins when used as anti-HIV microbicides.
Photodoping of amorphous chalcogenides by metals (1991)

Abstract The present paper reviews the results of experimental investigations of the photodoping of amorphous chalcogenides by metals, and in particular by silver. The kinetics of the photodissolution of the metal are described as also is the influence on the photodissolution rate of such factors as the wavelength and intensity of light, the composition and temperature of the semiconductor, and an external electric field. A separate section describes lateral diffusion. The properties of photodoped semiconductors (electrical, optical, photoelectric, etc.) are presented. The results in the literature are analysed, giving answers to such fundamental questions as the following. Where is the actinic light which is efficient for the photodissolution absorbed? Which is the diffusion-limiting step? What is the state of the diffusing species (neutral atoms or ions)? The dissolution of silver induced by electron or ion beams and the photodissolution of group II metals are mentioned. The experimental results are followed by a section on models for the photodissolution process with a detailed consideration of the processes at the metal-semiconductor boundary, the transport of the metal through the doped layer and the penetration of the metal species into the undoped semiconductor. Electronic processes at the doped-undoped chalcogenide interface are considered. The review is concluded by a section devoted to practical applications of the photodissolution process.
Physiology and molecular biology of the lignin peroxidases ofPhanerochaete chrysosporium (1994)

The white-rot basidiomycete Phanerochaete chrysosporium produces lignin peroxidases (LiPs), a family of extracellular glycosylated heme proteins, as major components of its lignin-degrading system. Up to 15 LiP isozymes, ranging in M(r) values from 38,000 to 43,000, are produced depending on culture conditions and strains employed. Manganese-dependent peroxidases (MnPs) are a second family of extracellular heme proteins produced by P. chrysosporium that are also believed to be important in lignin degradation by this organism. LiP and MnP production is seen during secondary metabolism and is completely suppressed under conditions of excess nitrogen and carbon. Excess Mn(II) in the medium, on the other hand, suppresses LiP production but enhances MnP production. Nitrogen regulation of LiP and MnP production is independent of carbon and Mn(II) regulation. LiP activity is also affected by idiophasic extracellular proteases. Intracellular cAMP levels appear to be important in regulating the production of LiPs and MnPs, although LiP production is affected more than MnP production. Studies on the sequencing and characterization of lip cDNAs and genes of P. chrysosporium have shown that the major LiP isozymes are each encoded by a separate gene. Each lip gene encodes a mature protein that is 343-344 amino acids long, contains 1 putative N-glycosylation site, a number of putative O-glycosylation sites, and is preceded by a 27-28-amino acid leader peptide ending in a Lys-Arg cleavage site. The coding region of each lip gene is interrupted by 8-9 introns (50-63 bp), and the positions of the last two introns appear to be highly conserved. There are substantial differences in the temporal transcription patterns of the major lip genes. The sequence data suggest the presence of three lip gene subfamilies. The genomic DNA of P. chrysosporium strain BKMF-1767 was resolved into 10 chromosomes (genome size of 29 Mb), and that of strain ME-446 into 11 chromosomes (genome size of 32 Mb). The lip genes have been localized to five chromosomes in BKMF-1767 and to four chromosomes in ME-446. DNA transformation studies have reported both integrative and non-integrative transformation in P. chrysosporium.
Symbolic pole/zero calculation using SANTAFE (1995)

The aim of symbolic analysis is to gain insight into circuit behavior. To study the behavior of analog circuits, the locations of the poles and zeros have to be known. Unfortunately, no general method exists to calculate the poles and zeros symbolically for polynomials of degree greater than four from transfer functions in coefficient form. The CAD tool SANTAFE (Symbolic Analysis of Transfer Functions) applies the signal-flow graph method, which permits to keep the result in a factorized or partially factorized form. The graphic view provided by a signal-flow graph offers insight into the internal interactions between the circuit elements and, as will be demonstrated, enables the user to perform circuit knowledge-based approximations. A novel procedure based on symbolic Newton-iteration, accurately calculates high-order transfer functions in the desired pole/zero form. Another special routine, based on element weight ratios rather than numerical values, enables the simplification of large symbolic expressions without numerical values for each parameter. With the program SANTAFE, even large networks can be analyzed symbolically. This will be shown with an example of a wide band BiCMOS operational amplifier.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Silicon micromachined high-contrast artificial dielectrics for millimeter-wave transformation optics antennas (2017)

Transformation optics methods and gradient index electromagnetic structures rely upon spatially varied arbitrary permittivity. This, along with recent interest in millimeter-wave lens-based antennas demands high spatial resolution dielectric variation. Perforated media have been used to fabricate gradient index structures from microwaves to THz but are often limited in contrast. We show that by employing regular polygon unit-cells (hexagon, square, and triangle) on matched lattices we can realize very high contrast permittivity ranging from 0.1-1.0 of the background permittivity. Silicon micromachining (Bosch process) is performed on high resistivity Silicon wafers to achieve a minimum permittivity of 1.25 (10% of Silicon) in the WR28 waveguide band, specifically targeting the proposed 39GHz 5G communications band. The method is valid into the THz band.
[Usefulness of Palliative Gastrojejunal Bypass Surgery]. (2015)

Gastrojejunal bypass surgery is found to have the potential to not only make relatively long-term oral ingestion possible, but also broaden available treatment options, such as home care or chemotherapy, thereby contributing to improved quality of life.
Irritable Bowel Syndrome Therapeutic Has Broad-Spectrum Antimicrobial Activity (2021)

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here, we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. Our results suggest otilonium bromide acts on enteric pathogens and may offer a new scaffold for poorly absorbed intestinal antimicrobial therapy.
Crystal structure of 3,8-di-tert-butyl-4-methoxy-1-methyl-9,10- diphenylmethylidenedioxy)dibenzo[b,d]pyran-6-one, C6H[O2C(C6H5)2](C4H9)COO(C6H)(CH3)(OCH3)(C4H9) (2000)

2), a = 10.7518(9) A, b= 10.9501(9) A,c = 14.372(1) A, a = 72.022(6), P = 73.190(6), y = 73.099(7), V= 1502.5 A 3 ,Z=2, R gl (F) = 0.061, wR K{ iF 2 ) = 0.182, 7= 293 K.
Golgi Apparatus Immunolocalization of Endomannosidase Suggests Post-Endoplasmic Reticulum Glucose Trimming: Implications for Quality Control (2000)

Trimming of N-linked oligosaccharides by endoplasmic reticulum (ER) glucosidase II is implicated in quality control of protein folding. An alternate glucosidase II-independent deglucosylation pathway exists, in which endo-alpha-mannosidase cleaves internally the glucose-substituted mannose residue of oligosaccharides. By immunogold labeling, we detected most endomannosidase in cis/medial Golgi cisternae (83.8% of immunogold labeling) and less in the intermediate compartment (15.1%), but none in the trans-Golgi apparatus and ER, including its transitional elements. This dual localization became more pronounced under 15 degrees C conditions indicative of two endomannosidase locations. Under experimental conditions when the intermediate compartment marker p58 was retained in peripheral sites, endomannosidase was redistributed to the Golgi apparatus. Double immunogold labeling established a mutually exclusive distribution of endomannosidase and glucosidase II, whereas calreticulin was observed in endomannosidase-reactive sites (17.3% in intermediate compartment, 5.7% in Golgi apparatus) in addition to the ER (77%). Our results demonstrate that glucose trimming of N-linked oligosaccharides is not limited to the ER and that protein deglucosylation by endomannosidase in the Golgi apparatus and intermediate compartment additionally ensures that processing to mature oligosaccharides can continue. Thus, endomannosidase localization suggests that a quality control of N-glycosylation exists in the Golgi apparatus.
Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research (2022)

Cannabinoid CB1 receptors (CB1Rs) have been major targets in medication development for the treatment of substance use disorders. However, clinical trials with rimonabant, a CB1R antagonist/inverse agonist, failed due to severe side effects. Here, we evaluated the therapeutic potential of PIMSR, a neutral CB1R antagonist lacking an inverse agonist profile, against cocaine's behavioral effects in experimental animals. We found that systemic administration of PIMSR dose-dependently inhibited cocaine self-administration under fixed-ratio (FR5), but not FR1, reinforcement, shifted the cocaine self-administration dose-response curve downward, decreased incentive motivation to seek cocaine under progressive-ratio reinforcement, and reduced cue-induced reinstatement of cocaine seeking. PIMSR also inhibited oral sucrose self-administration. Importantly, PIMSR alone is neither rewarding nor aversive as assessed by place conditioning. We then used intracranial self-stimulation (ICSS) to explore the possible involvement of the mesolimbic dopamine system in PIMSR's action. We found that PIMSR dose-dependently attenuated cocaine-enhanced ICSS maintained by electrical stimulation of the medial forebrain bundle in rats. PIMSR itself failed to alter electrical ICSS, but dose-dependently inhibited ICSS maintained by optical stimulation of midbrain dopamine neurons in transgenic DAT-Cre mice, suggesting the involvement of dopamine-dependent mechanisms. Lastly, we examined the CB1R mechanisms underlying PIMSR's action. We found that PIMSR pretreatment attenuated Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC)- or ACEA (a selective CB1R agonist)-induced reduction in optical ICSS. Together, our findings suggest that the neutral CB1R antagonist PIMSR deserves further research as a promising pharmacotherapeutic for cocaine use disorder.