gebhart/patrepeval huggingface dataset:
A unique isolate of Bacillus thuringiensis serovar japonensis with a high larvicidal activity specific for scarabaeid beetles (1992)

Journal Article A unique isolate of Bacillus thuringiensis serovar japonensis with a high larvicidal activity specific for scarabaeid beetles Get access M. Ohba, M. Ohba Institute of Biological Control, Faculty of Agriculture, Kyushu University, Fukuoka 812 Search for other works by this author on: Oxford Academic Google Scholar H. Iwahana, H. Iwahana Institute of Biological Control, Faculty of Agriculture, Kyushu University, Fukuoka 812*Department of Applied Biological Sciences, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 Search for other works by this author on: Oxford Academic Google Scholar S. Asano, S. Asano †Tsukuba Laboratories of Research and Development, Kubota Corp., Ryugasaki, Ibaraki 301, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Suzuki, N. Suzuki †Tsukuba Laboratories of Research and Development, Kubota Corp., Ryugasaki, Ibaraki 301, Japan Search for other works by this author on: Oxford Academic Google Scholar R. Sato, R. Sato *Department of Applied Biological Sciences, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183Institute of Biological Control, Faculty of Agriculture, Kyushu University, Fukuoka 812 Search for other works by this author on: Oxford Academic Google Scholar H. Hori H. Hori †Tsukuba Laboratories of Research and Development, Kubota Corp., Ryugasaki, Ibaraki 301, Japan Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 14, Issue 2, 1 February 1992, Pages 54–57, https://doi.org/10.1111/j.1472-765X.1992.tb00646.x Published: 01 February 1992 Article history Received: 12 September 1991 Accepted: 20 October 1991 Published: 01 February 1992
Abstract SY05-01: microRNAs: Micromanagers of human cancers (2012)

Abstract The newly discovered differential expression in numerous tissues, key cellular processes and multiple diseases for several families of long and short non-codingRNAs (ncRNAs, RNAs that do not codify for proteins but for RNAs with regulatory functions), including the already famous class of microRNAs (miRNAs) strongly suggest that the scientific and medical communities have significantly underestimated the spectrum of ncRNAs whose altered expression has significant consequences in diseases. MicroRNA and other short or long non-codingRNAs alterations are involved in the initiation, progression and metastases of human cancer. The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes. The causes of the widespread differential expression of non-codingRNAs in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the processing machinery. MicroRNA and other short or long non-codingRNAs expression profiling of human tumors has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify non-codingRNAs that may represent downstream targets of activated oncogenic pathways or that are targeting protein coding genes involved in cancer. Recent studies proved that miRNAs and non-coding ultraconserved genes are main candidates for the elusive class of cancer predisposing genes and that other types of non-codingRNAs participate in the genetic puzzle giving rise to the malignant phenotype. Last, but not least, the shown expression correlations of these new ncRNAs with cancer metastatic potential and overall survival rates suggest that at least some member of these novel classes of molecules could potentially find use as biomarkers or novel therapeutics in cancers and other diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr SY05-01. doi:1538-7445.AM2012-SY05-01
Xylanase, protease and superdosing phytase interactions in broiler performance, carcass yield and digesta transit time (2017)

The interaction of xylanase, protease and superdosing (1,500 FTU/kg) phytase in a 2 × 2 × 2 factorial arrangement was studied in broilers fed sorghum-based diets. A total of 2,800 one-day-old unsexed Ross 308 chicks were housed in 56 pens with 50 birds per pen, with or without inclusion of xylanase, protease and phytase, totaling 8 treatments and 7 replicates per treatment. Body weight (BW) and feed intake (FI) were measured at 21 and 42 days of age, and mortality corrected feed conversion ratio (FCR) was calculated for each period and cumulatively. Tibia ash and carcass yield were determined in 2 birds per replicate at 21 and 42 days of age, respectively. Digesta transit time was determined at 21, 28, 35 and 42 days of age using 5 birds per replicate. Results showed that superdosing phytase increased BW and FI at 42 days of age (<i>P</i> < 0.05) and xylanase improved FCR (<i>P</i> < 0.05). Xylanase and phytase also positively influenced carcass yield and breast weight, respectively. Overall, inclusion of superdosing phytase increased transit time when included in a diet containing xylanase, and no change with protease inclusion. In conclusion, the beneficial effects of xylanase, protease and superdosing phytase in broiler performance were not additive. This limitation is likely not related to the lack of efficacy of any one of the individual enzymes but to a limitation of the bird to respond additively to successive additions of enzymes.
Discrete-synapse recurrent neural network for nonlinear system modeling and seismic signal classification (2010)

A passive seismic sensor is very useful to a perimeter protection system since it is cheap, easily deployable and concealed underground so as not to be detected by intruders. However, its limited frequency response is challenging enough to necessitate wider temporal analysis or a hybrid method which combines spectral analysis and cadence analysis including gait pattern analysis. Although they are mutually complementary and independent analysis methods, they are computationally expensive and cause trade-off issues during the simplification process for hardware implementation on a small chip. In terms of analysis method, although Dynamic Synapse Neural Network (DSNN) as a biologically-inspired model is a good candidate for more fundamental understanding of seismic signals capturing its dynamics with wider temporal information, it is also computationally expensive in the terms of hardware implementation and inefficient in training. 
In this thesis, a simplified model of DSNN, Discrete-Synapse Recurrent Neural Network (DSRNN) is explored and developed so that the model not only does the seismic signal classification task with a more fundamental understanding of the signal, but also does the nonlinear system modeling task learning of a DSNN as a nonlinear system, establishing the DSRNN as a simplified and replaceable model of DSNN. 
DSRNN I was designed based on the differential equations for DSNN’s presynapse and nonlinear characteristics of the other part of DSNN. Also DSRNN II was designed with additional recurrent connections to DSRNN I so that it could capture wider temporal dynamics of the signal. DSRNN II’s nonlinear system modeling task learning of a 2x2 DSNN compared to DSRNN I’s learning of a single DSNN proved that DSRNN II outperforms DSRNN I by virtue of added recurrent connections. Also, seismic signal classification task produced the same conclusion by a much lower false recognition rate from DSRNN II and showed the possibility of a simple hardware implementation of a biologically-inspired model without losing its functionalities.
Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision (2017)

Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC) is universally accepted, but the mode of action of NEIL1 is still debated. Based on genetic experiments, it has been suggested that NEIL1 acts redundantly with TDG and excises 5fC and 5caC directly. However, this result has been disputed, and it was suggested instead that NEIL1 is recruited by the monofunctional TDG for the 2'-deoxyribose excision step. Using purified human NEIL1 and its catalytically impaired P2T and E3Q variants as controls, we detect NEIL1 activity on 5caC, but not a 5fC containing dsDNA substrate. We confirm direct NEIL1 TDG binding and NEIL1 mediated 2'-deoxyribose excision downstream of TDG glycosylase activity. NEIL1 acts not only downstream of TDG, but also enhances TDG activity on 5fC or 5caC containing DNA. NEIL1 mediated enhancement of the TDG glycosylase activity is substrate specific and does not occur for dsDNA with a T/G mismatch.
Incremental formal verification of hardware (2011)

Formal verification is a reliable and fully automatic technique for proving correctness of hardware designs. Its main drawback is the high complexity of verification, and this problem is especially acute in regression verification, where a new version of the design, differing from the previous version very slightly, is verified with respect to the same or a very similar property. In this paper, we present an efficient algorithm for incremental verification, based on the ic3 algorithm, that uses stored information from the previous verification runs in order to improve the complexity of re-verifying similar designs on similar properties. Our algorithm applies both to the positive and to the negative results of verification (that is, both when there is a proof of correctness and when there is a counterexample). The algorithm is implemented and experimental results show improvement of up to two orders of magnitude in running time, compared to full verification.
Long collector mirror lifetime demonstration around 100W average LP-EUV source for semiconductor high volume manufacturing (Conference Presentation) (2018)

We have been developing CO2-Sn-LPP EUV light source which is the most promising solution as the 13.5nm high power light source for HVM EUVL. Unique and original technologies such as; combination of pulsed CO2 laser and Sn droplets, dual wavelength laser pulses shooting and mitigation with magnetic field have been developed in Gigaphoton Inc.. We have developed first practical source for HVM; "GL200E" 1) in 2014. We have proved high average power CO2 laser more than 20kW at output power cooperate with Mitsubishi electric cooperation2). Pilot#1 is up running and its demonstrates HVM capability; EUV power recorded at111W average (117W in burst stabilized, 95% duty) with 5% conversion efficiency for 22hours operation in October 20163). Availability is potentially achievable at 89% (2weeks average), also superior magnetic mitigation has demonstrated promising mirror degradation rate (= 0.4%/Gp) above 100W level operation in burst (30W in average) with dummy mirror test.4). Recently we have demonstrated actual collector mirror reflectivity degradation rate is less than -0.4%/Gp by using real collector mirror around 100W ( at I/F clean ) in average power during one week operation. We will report latest data at symposium Reference 1) Hakaru Mizoguchi, et. al.: "Sub-hundred Watt operation demonstration of HVM LPP-EUV source", Proc. SPIE 9048, (2014) 2) Yoichi Tanino et.al.:" A Driver CO2 Laser Using Transverse-flow CO2 Laser Amplifiers", EUV Symposium 2013, ( Oct.6-10.2013, Toyama) 3) Hakaru Mizoguchi et al.:" Performance of 250W High Power HVM LPP-EUV Source", Proc. SPIE 10143, Extreme Ultraviolet (EUV) Lithography VIII (2017) 4) Hakaru Mizoguchi, et al: " High Power HVM LPP-EUV Source with Long Collector Mirror Lifetime", SPIE Advanced Lithography ( 2018)
Anti-CD20 monoclonal antibody (rituximab) in the treatment of pemphigus (2005)

This study highlights the prolonged effect and disease control after one single course of rituximab and further extends the spectrum of treatments of bullous autoimmune disorders.
CONTINUOUS VERSUS INTERMITTENT RENAL REPLACEMENT THERAPY (1999)

Society of Critical Care Medicine; 28th Educational and Scientific Symposium; San Francisco, California, USA; January 23-27, 1999: Poster Presentations: Poster Hall
Identification of a pheromone regulating caste differentiation in termites (2010)

The hallmark of social insects is their caste system: reproduction is primarily monopolized by queens, whereas workers specialize in the other tasks required for colony growth and survival. Pheromones produced by reigning queens have long been believed to be the prime factor inhibiting the differentiation of new reproductive individuals. However, there has been very little progress in the chemical identification of such inhibitory pheromones. Here we report the identification of a volatile inhibitory pheromone produced by female neotenics (secondary queens) that acts directly on target individuals to suppress the differentiation of new female neotenics and identify n-butyl-n-butyrate and 2-methyl-1-butanol as the active components of the inhibitory pheromone. An artificial pheromone blend consisting of these two compounds had a strong inhibitory effect similar to live neotenics. Surprisingly, the same two volatiles are also emitted by eggs, playing a role both as an attractant to workers and an inhibitor of reproductive differentiation. This dual production of an inhibitory pheromone by female reproductives and eggs probably reflects the recruitment of an attractant pheromone as an inhibitory pheromone and may provide a mechanism ensuring honest signaling of reproductive status with a tight coupling between fertility and inhibitory power. Identification of a volatile pheromone regulating caste differentiation in a termite provides insights into the functioning of social insect colonies and opens important avenues for elucidating the developmental pathways leading to reproductive and nonreproductive castes.
Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters (2005)

A series of aryl-substituted meperidine analogues was synthesized, and the binding affinities were determined at the DAT, SERT, and NET as well as at mu-opioid receptors. Generally the analogues exhibited increased affinity for the DAT and SERT relative to meperidine but exhibited low binding affinity for the NET. The 2-naphthyl derivative 7f was the most potent ligand at the SERT (K(i) = 0.0072 muM) and was the most selective ligand for the SERT over the DAT (DAT/SERT = 158) and mu-opioid receptors (mu/SERT = 281). The 3,4-dichlorophenyl derivative 7e was the most potent ligand at the DAT (K(i) = 0.125 muM) and was the most selective ligand for the DAT over mu-opioid receptors (mu/DAT = 16.3) but remained slightly more selective for the SERT over the DAT(DAT/SERT = 6.68). Three compounds, the 3,4-dichlorophenyl derivative 7e and the 2-naphthyl analogues 6f and 7f, were identified that were more potent at the DAT than meperidine and that exhibited well-defined biphasic dopamine uptake inhibition similar to meperidine. However, none of the analogues tested produced locomotor effects or substituted for cocaine in drug discrimination studies, suggesting that the mu-opioid effects of these analogues may contribute to the poor efficacy observed in vivo.
High Output Power InGaN Ultraviolet Light-Emitting Diodes Fabricated on Patterned Substrates Using Metalorganic Vapor Phase Epitaxy (2001)

Ultraviolet (UV) light-emitting diodes (LEDs) with an InGaN multi-quantum-well (MQW) structure were fabricated on a patterned sapphire substrate (PSS) using a single growth process of metalorganic vapor phase epitaxy. In this study, the PSS with parallel grooves along the &lt;1120&gt; sapphire direction was fabricated by standard photolithography and subsequent reactive ion etching (RIE). The GaN layer grown by lateral epitaxy on a patterned substrate (LEPS) has a dislocation density of 1.5×10 8 cm -2 . The LEPS-UV-LED chips were mounted on the Si bases in a flip-chip bonding arrangement. When the LEPS-UV-LED was operated at a forward-bias current of 20 mA at room temperature, the emission wavelength, the output power and the external quantum efficiency were estimated to be 382 nm, 15.6 mW and 24%, respectively. With increasing forward-bias current, the output power increased linearly and was estimated to be approximately 38 mW at 50 mA.
Analysis of Growth Curves in Children After Adenotonsillectomy (2014)

Weight gain after adenotonsillectomy occurs primarily in patients who are smaller and younger at the time of surgery and does not correlate with increased rates of obesity.
Forehead Fat Grafting: Asian Facial Contouring and Augmentation (2019)

Therapeutic, IV.
Visual Synset: Towards a higher-level visual representation (2008)

We present a higher-level visual representation, visual synset, for object categorization. The visual synset improves the traditional bag of words representation with better discrimination and invariance power. First, the approach strengthens the inter-class discrimination power by constructing an intermediate visual descriptor, delta visual phrase, from frequently co-occurring visual word-set with similar spatial context. Second, the approach achieves better intra-class invariance power, by clustering delta visual phrases into visual synset, based their probabilistic dasiasemanticspsila, i.e. class probability distribution. Hence, the resulting visual synset can partially bridge the visual differences of images of same class. The tests on Caltech-101 and Pascal-VOC 05 dataset demonstrated that the proposed image representation can achieve good accuracies.
Adhesive slip process between a carbon nanotube and a substrate (2013)

Since their discovery in 1991, carbon nanotubes (CNTs) have been attractive components for nanoelectromechanical (NEM) devices because of their excellent mechanical and electrical properties. Several CNT-based NEM devices have been reported. Experimental investigations have discovered that the force required for a CNT to slip on a SiO2 substrate is almost constant in the range of contact lengths from 140 to 246?nm and increases with the contact length for greater lengths. This study develops a theory based on the continuum mechanics to explain this observed phenomenon. The critical force needed to cause the CNT to slip over the whole substrate is determined by applying a beam theory which includes the bending, shear, and axial deformations of the CNT. At the stick?slip transition, the work of adhesion contributes a concentrated force and a concentrated moment to produce discontinuities in the internal forces and moments of the CNT. The modelling results obtained here provide the external force required for complete slip versus a dimensionless parameter related to the shear stress and the contact length. A comparison of the modelling result and the experimental data from the literature shows good agreement.
Anti-RBD IgG antibodies and neutralizing antibody levels after the second BNT162b2 dose in patients with plasma cell disorders (2023)

Patients with plasma cell disorders (PCD) are at an increased risk for severe morbidity and mortality due to COVID-19. Recent data have suggested that patients with hematological malignancies, including those with PCD, have suboptimal antibody response to COVID-19 vaccination. We compared the antibody titers of 213 patients with PCD to those of 213 immunocompetent healthcare workers after the second vaccine dose of the BNT162b2 mRNA vaccine. Blood samples were taken 2-4 weeks after the second vaccination and analyzed for anti-receptor binding-domain immunoglobulin G (RBD-IgG) antibodies and neutralizing antibodies (NA). At a median of 20 days after the second vaccine dose, 172 patients (80.8%) developed anti-RBD-IgG antibodies with a geometric mean titer (GMT) of 2.7 (95% confidence interval [CI], 2.4-3.1). In the control group 210 (98.9%) developed anti-RBD-IgG antibodies after a median of 21 days, with a GMT of 5.17 (95%CI, 4.8-5.6), p<0.0001. NA were observed in 151 patients with MM (70.9%) and in 210 controls (98.9%). The GMT of NA in patients with MM and controls was 84.4 (95% CI, 59.0-120.6), and 420.2 (95% CI, 341.4-517.1), respectively (p<0.0001). Multivariable logistic regression revealed that the number of prior therapy lines and age were significant predictors of poor humoral response among patients with MM. Injection site reaction, headache and fatigue were the most common adverse events after vaccination. Adverse events were less common in patients with MM than in controls. In conclusion, a significant percentage of patients with MM developed protecting NA to the BNT162b2 mRNA vaccine, which appears to be safe in this patient population.
MECHANICAL DAMPING SYSTEMS FOR TRAFFIC SIGNAL MAST ARMS (1998)

Several mast arm failures have been observed in Florida and other states from fatigue caused by wind-induced vibrations. An economical method to mitigate the effects of wind induced vibration on these types of structures is to install mechanical damping systems directly on the mast arm. These devices limit the amplitude and duration of vibrations resulting in an increase in the design life of the structure. This report describes the development and testing of several different damping devices for cantilevered mast arm structures. Prototype damping devices were tested on an 11.3 m (37 ft) mast arm constructed in the Structures Laboratory at the University of Florida. Successful devices were then field tested on several different lengths of mast arms (11.0 m to 21.4 m) to determine the effectiveness over the full range of installations. The optimum device developed was relatively insensitive to the natural frequency of the mast arm and consists of a tapered steel tube, weight and spring system.
DensiForm® Technology for Wrought-Steel-Like Performance of Powder Metal Components (2006)

<div class="htmlview paragraph">Power transmission components for automotive applications require high static and dynamic mechanical properties to insure long term system reliability. Historically, high quality wrought steel alloys have been the only materials used in the series manufacturing of high torque transmitting components such as one-way clutch races, transmission gears, sprockets and bearing races. Although powder metal technology offers lower cost components, limitations in static and fatigue properties of sintered materials preclude utilization of conventional powder metallurgy in these applications. To address these shortcomings we have developed DensiForm<sup>®</sup>, a surface densification technology. Specifically, a densification process is utilized with the net result of a full density layer on critical areas up to 1 mm deep into the part and an overall component density above 92% of the theoretical density. The combination of full density on critical areas, high core density and powder metal alloying flexibility enable the production of sintered components which match the performance of wrought steel in highly stressed applications. Contact and bending fatigue properties are presented along with applications to powertrain components.</div>