gebhart/patrepeval huggingface dataset:
Maximizing the success rate of minimal model insulin sensitivity measurement in humans: the importance of basal glucose levels (2001)

Minimal model analysis of glucose and insulin concentrations in the intravenous glucose tolerance test (IVGTT) has been widely used to obtain a measure of insulin sensitivity in humans. Issues of model validity and IVGTT protocol have been explored extensively. Less attention has been paid, however, to the computer programming protocol for estimating the model parameters (programming implementation). Minimal model analysis of data from an IVGTT protocol involving a high glucose dose (0.5 g/kg) and a reduced sample schedule, employed in healthy pre- or post-menopausal women, healthy men or men with coronary heart disease or chronic heart failure (20 in each group), was undertaken according to 12 different programming implementations using a commercially available model-equation-solving program. The ability of the program to arrive at an acceptable solution to the model equations gave a success rate of between 39% and 96%, depending on the implementation. Variation in basal glucose assignment significantly affected the magnitude of estimates of insulin sensitivity. The maximum modelling success rate was achieved by introduction of an imputed glucose measurement at 360 min from the glucose injection, taking the basal glucose level as the fasting glucose concentration, and overweighting the initial glucose measurement after a delay for mixing. Use of this implementation to analyse data from a study comparing insulin sensitivities obtained using the minimal model and a euglycaemic clamp reference gave a correlation of 0.80 (P < 0.001) between the two methods. Straightforward variations in programming implementation, involving appropriate assignment of the basal glucose concentration and use of an imputed glucose measurement signifying re-establishment of basal glucose levels following the IVGTT, can considerably improve modelling success rate.
Gyejigachulbu‐Tang Relieves Oxaliplatin‐Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation (2014)

Activation of spinal glial cells plays a crucial role in the pathogenesis of neuropathic pain. An administration of oxaliplatin, an important anticancer drug, often induces acute neuropathic cold hypersensitivity and/or mechanical hypersensitivity in patients. Gyejigachulbu-tang (GBT), a herbal formula comprising Cinnamomi Cortex, Paeoniae Radix, Atractylodis Lanceae Rhizoma, Zizyphi Fructus, Glycyrrhizae Radix, Zingiberis Rhizoma, and Aconiti Tuber, has been used in East Asia to treat various pain symptoms, especially in cold patients. This study investigated whether and how GBT alleviates oxaliplatin-induced cold and mechanical hypersensitivity in rats. The behavioral signs of cold and mechanical hypersensitivity were evaluated by a tail immersion test in cold water (4°C) and a von Frey hair test, respectively. The significant cold and mechanical hypersensitivity were observed 3 days after an oxaliplatin injection (6 mg/kg, i.p.). Daily oral administration of GBT (200, 400, and 600 mg/kg) for 5 days markedly attenuated cold and mechanical hypersensitivity. Immunoreactivities of glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by GBT administration. These results indicate that GBT relieves oxaliplatin-induced cold and mechanical hypersensitivity in rats possibly through the suppression of spinal glial activation.
Abstract 15: Serum Amyloid A is Not Just an HDL-Associated Lipoprotein (2017)

Serum Amyloid A (SAA) is traditionally thought to be only found with HDL; however, recently several groups have found that SAA is found on apoB-containing lipoproteins (LDL and VLDL) under some circumstances. The goal of this study was to determine the relative lipoprotein association of SAA. Native human acute phase SAA was isolated from acute phase plasma collected from patients undergoing cardiovascular bypass surgery; the SAA was purified and delipidated. Plasma was collected from a group of healthy, non-obese humans with low levels of SAA (&lt; 2 mg/L) and lipoproteins (VLDL, LDL and HDL) were isolated by density gradient ultracentrifugation. The delipidated SAA (at 2 concentrations) was incubated in vitro with the various lipoprotein preparations then samples were re-isolated by fast protein liquid chromatography and SAA was analyzed by ELISA and immunoblot. When SAA was incubated with any single lipoprotein all of the SAA was found associated with that lipoprotein and none remained in a lipid-free form. When SAA was incubated with a mixture of VLDL, LDL and HDL (based on equal protein and corresponding to concentrations in plasma) a majority of SAA (50-60%) was found on HDL with the remaining SAA found on VLDL and LDL. When SAA first complexed to HDL was added to a mixture of SAA-free LDL and VLDL the majority of SAA remained with the HDL (76-86%) but 5-10% of the SAA was found on each of LDL and VLDL. When SAA first complexed to either apoB-containing lipoprotein was then added to a mixture of HDL and the other apoB-containing lipoprotein most SAA moved to HDL (55-70%) but the remainder was found on the apoB-containing particles. Thus, SAA can move between lipoprotein particles in vitro. To determine if the presence of SAA on apoB-containing lipoproteins had a functional effect we evaluated lipoprotein-proteoglycan binding affinity. Proteoglycan mediated lipoprotein retention in the vessel wall is thought to be one of the key steps in initiation of atherosclerosis. Compared to SAA-free LDL or VLDL, the presence of SAA on apoB-containing lipoproteins caused increased proteoglycan binding affinity. Thus, SAA is not simply an HDL lipoprotein, but SAA can move between lipoprotein particles, and the presence of SAA on apoB particles may increase their atherogenicity.
Improved Synthesis of Zebularine [1-(β-D-Ribofuranosyl)-Dihydropyrimidin-2-One] Nucleotides as Inhibitors of Human Deoxycytidylate Deaminase (1995)

The 2'-deoxy (2a) and 2'-ara-fluoro (3a) derivatives of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one, 1a] were phosphorylated in high yield to the 5'-nucleotides 2b and 3b, respectively, and characterized by HPLC, enzyme degradation, 1H, 13C and 31P NMR, and high resolution mass spectral analysis. Their inhibitory activity against partially purified MOLT-4 deoxycytidylate deaminase (dCMPD) in the presence of the allosteric effector deoxycytidine triphosphate (dCTP) and Mg+2 ion was examined. Compounds 2b and 3b inhibited dCMPD with Ki values of 2.1 x 10(-8) M and 1.2 x 10(-8) M, respectively. The parent nucleotide, zebularine monophosphate 1b was ineffective at concentrations > 100 mumol. The effect of the nucleosides, 1a-3a, as well as tetrahydrouridine (THU) and 2'-deoxy THU (dTHU), on the cellular production of DNA precursors was examined in human MOLT-4 peripheral lymphoblasts. It was shown that 1a, 2a and 3a all elevated intracellular dCTP and TTP levels in whole cells with the most powerful effect elicited by 1a. The 2'-fluoro derivative 3a was chemically phosphorylated much more cleanly and higher yield than 2a, without the formation of diphosphorylated by-products. This compound was found to be infinitely less sensitive to acid-catalyzed degradation than 2a. Since the substitution of fluorine for hydrogen had a slight potentiating effect on the dCMPD inhibitory activity while stabilizing the compound toward acid-catalyzed and enzymatic depyrimidination, compound 3b emerges as a very attractive tool for the pharmacological modulation of pyrimidine deaminase activity.
Regulation of Receptor Trafficking by GRKs and Arrestins (2006)

To ensure that extracellular stimuli are translated into intracellular signals of appropriate magnitude and specificity, most signaling cascades are tightly regulated. One of the major mechanisms involved in the regulation of G protein-coupled receptors (GPCRs) involves their endocytic trafficking. GPCR endocytic trafficking entails the targeting of receptors to discrete endocytic sites at the plasma membrane, followed by receptor internalization and intracellular sorting. This regulates the level of cell surface receptors, the sorting of receptors to degradative or recycling pathways, and in some cases the specific signaling pathways. In this chapter we discuss the mechanisms that regulate receptor endocytic trafficking, emphasizing the role of GPCR kinases (GRKs) and arrestins in this process.
Instance selection for efficient and reliable camera calibration (2016)

The popularity of cameras for perception is enabled in part by powerful intrinsic calibration routines, commonly requiring a user to manually collect images of a known calibration target. The manual nature of this process produces training data that is unevenly spread in the camera relative pose space. If we desire camera parameters that perform well on average over the entire relative pose space, training on such a dataset results in poor performance. To address this, we show that reasoning about the training data distribution to select a more uniformly-spread subset of images produces more accurate and stable calibrations with fewer images. Our approach can be used easily with most camera calibration algorithms. We demonstrate in large-scale physical experiments the effect of non-uniform training data and show that our approach outperforms baselines in reprojection error and parameter variance.
Crack patterns in binary mixes of dairy colloids: The impact of protein properties. (2019)

The production of milk powders is a strategic sector of the dairy industry. Due to its complex macromolecular composition, shedding light on the mechanisms governing milk drying constitutes a main industrial concern and a scientific challenge at the same time. In this study, we used the single droplet[1] and the directional drying[2] approaches to investigate the evaporation of colloidal mixes of the two major milk proteins (whey protein isolates and native phosphocaseinates). Notably, we observed the crack development in the samples to evaluate the competitive impact of the physico-chemical properties of whey proteins (rigid globular shape) and casein micelles (deformable sponge-like structure) on the drying process. Our outcomes are potentially useful to better control the functional properties of milk powders. Furthermore, they contribute to improve the understanding of the drying mechanisms in binary colloidal systems, which are still far from being fully elucidated.
Synthetic Oligosaccharides In Glycobiology (1994)

Glycoconjugates play important roles in biological systems via recognition of oligosaccharides. Natural glycoconjugates are much too complicated for the currently available analytical and separation methodologies to allow dissection of their individual roles in biological systems to be clearly defined. Therefore chemical and enzymatic syntheses to produce useful quantities of oligosaccharides of definitive structures are very important in understanding functions of glycoconjugates. Refinement of oligosaccharide synthesis for mass production and cost reduction is urgently needed for development of glycobiotechnology.
Local Color Oppugnant Mesh Extrema Patterns: A New Feature Descriptor for Image Retrieval (2017)

Objectives: This paper presents a new feature extractor which we named as Local Color Oppugnant Mesh Extrema Patterns (LCOMeEP) for retrieval of images. Methods/Statistical Analysis: The suggested method gathers the colortexture statistics among the RGB (Red, Green and Blue) and gray scale of the given image. The color-texture statistics is extracted based on mesh extrema which assembles the relationship among the neighbors using extrema. Findings: The proposed method is diverse from the Directional Local Extrema Patterns (DLEP) collect the directional information which is based on local extrema in an image. Whereas the method presented in this paper, (LCOMeEP) gathers the mesh extremas amid the RgG (red, gray, green), GgB (green, gray, blue) and BgR (blue, gray, red) spaces. The enactment of the presented technique is amended by assimilating the LCOMeEPs with histograms of HSV (hue, saturation, value). The enactment of the research work is estimated by simulating on standard data sets, Corel-5K and Corel-10K in context of recall, precision, Average Retrieval Rate (ARR) and Average Retrieval Precision (ARP). Application/Improvements: The outcome after inspection illustrates a substantial enhancement as related to the contemporary features for image retrieval. Keywords: Image Retrieval, Local Binary Patterns (LBP), Local Extrema Patterns, Local Oppugnant Patterns, Pattern Recognition, Texture
Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery (2022)

In our pilot study, AS-OCTA was able to detect changes in the episcleral VD following trabecular bypass MIGS, which may be a useful modality to evaluate surgical outcomes if validated in future studies.
Distributed Acquisition and Image Super-Resolution Based on Continuous Moments from Samples (2006)

Recently, new sampling schemes were presented for signals with finite rate of innovation (FRI) using sampling kernels reproducing polynomials or exponentials. In this paper, we extend those sampling schemes to a distributed acquisition architecture in which numerous and randomly located sensors are pointing to the same area of interest. We emphasize the importance played by moments and show how to acquire efficiently FRI signals with a set of sensors. More importantly, we also show that those sampling schemes can be used for accurate registration of affine transformed and low-resolution images. Based on this, a new super-resolution algorithm was developed and showed good preliminary results.
ADSNARK: Nearly Practical and Privacy-Preserving Proofs on Authenticated Data (2015)

We study the problem of privacy-preserving proofs on authenticated data, where a party receives data from a trusted source and is requested to prove computations over the data to third parties in a correct and private way, i.e., The third party learns no information on the data but is still assured that the claimed proof is valid. Our work particularly focuses on the challenging requirement that the third party should be able to verify the validity with respect to the specific data authenticated by the source -- even without having access to that source. This problem is motivated by various scenarios emerging from several application areas such as wearable computing, smart metering, or general business-to-business interactions. Furthermore, these applications also demand any meaningful solution to satisfy additional properties related to usability and scalability. In this paper, we formalize the above three-party model, discuss concrete application scenarios, and then we design, build, and evaluate ADSNARK, a nearly practical system for proving arbitrary computations over authenticated data in a privacy-preserving manner. ADSNARK improves significantly over state-of-the-art solutions for this model. For instance, compared to corresponding solutions based on Pinocchio (Oakland'13), ADSNARK achieves up to 25x improvement in proof-computation time and a 20x reduction in prover storage space.
The effect of the immunophilin ligands rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines. (1992)

The immunosuppressive drugs FK506 and cyclosporin A have an identical spectrum of activities with respect to IgE receptor (Fc epsilon RI)-mediated exocytosis from mast cells and T cell receptor-mediated transcription of IL-2. These findings suggest a common step in receptor-mediated signal transduction leading to exocytosis and transcription and imply that immunosuppressive drugs target specific signal transduction pathways, rather than specific cell types. This hypothesis is supported by studies on the effect of rapamycin on IL-3 dependent proliferation of the rodent mast cell line PT18. Rapamycin inhibits proliferation of PT18 cells, achieving a plateau of 80% inhibition at 1 nM. This inhibition is prevented in a competitive manner by FK506, a structural analogue of rapamycin. Proliferation of rat basophilic leukemia cells and WEHI-3 cells was also inhibited, at doses comparable to those shown previously to inhibit IL-2-dependent proliferation of cytotoxic T lymphocyte line (CTLL) cells. In contrast, proliferation of A-431 cells, a epidermoid cell line, was not affected by rapamycin. DNA histograms indicate that complexes formed between the rapamycin-FK506-binding protein (FKBP) and rapamycin arrest-proliferating PT18 cells in the G0/G1-phase. It is concluded that FKBP-rapamycin complexes may inhibit proliferative signals emanating from IL-3 receptors, resulting in growth arrest of cytokine-dependent, hematopoietic cells.
RAPID RECOVERY FROM SYNCOPE. (1907)

For overcomming cerebral anemia it is the common practice to lower the head, according to the accepted theory, to permit the blood to reach the brain without working against gravity. To do this the patient is made to lie supine. In fact, the unconsciousness and fall of a fainting person is a natural provision to bring about the same end. In the absence of medicinal restoratives the treatment of unconsciousness caused by mental excitement or emotion, slight pain, excessive heat or other nervous causes is deficient in that the end reaction, cerebral hyperemia, is usually not sufficiently sought. In case of fainting from being in overcrowded rooms, from exciting surroundings, from slight concussion or other pain or discomfort, the most rapid relief comes from forcing the blood out of the abdomen, where it has largely collected. This is of more avail than to elevate or to compress the extremities, and
System performance of interference alignment under TDD mode with limited backhaul capacity (2015)

This paper considers a MIMO interference system where interference alignment (IA) technique is adopted to manage the problem of interference. We consider a time division duplex (TDD) system where each transmitter estimates its channel state information (CSI) by probing the receivers. In addition, the transmitters share their local CSI estimate between each other using a backhaul links of limited capacity. A quantization over the backhaul is therefore required to reduce the amount of information to exchange. We study in this paper the impact of this quantization on the system performance and determine the optimal number of transmitter-receiver pairs that maximizes the system throughput.
1A2-R04 Development of Micro-needle Electrode Array for Electro Tactile Display(VR and Interface) (2013)

This paper describes electro tactile display with micro-needle electrodes that stimulate tactile receptors using electric stimulation. Electro tactile displays can be thin and flexible, however, the high electric impedance of the stratum corneum requires high voltage to stimulate the tactile receptors. In our device, we use needles as electrodes and the needle length was designed to have approximately the same length as the stratum corneum so as not to injure nerve area. This device allowed subjects to feel tactile sensation with lower voltage than a flat electrode array with good repeatability. In addition, the tactile sensation was created in the vicinity of the needles, i.e., tactile display with a high spatial resolution was achieved.
Prograde and retrograde precession of a fluid-filled cylinder (2021)

Abstract We numerically study precession driven flows in a cylindrical container whose nutation angle varies between 60 and 90 degrees for prograde and retrograde precession. For prograde precession we observe sharp transitions between a laminar and a turbulent flow state with low and high geostrophic axisymmetric flow components related with a centrifugal instability, while for retrograde precession a rather smooth transition between a low state and a high state occurs. At the same time prograde and perpendicular precession shows an abrupt breakdown of the flow directly excited by the forcing mechanism, which is not the case for retrograde motion. We characterize the corresponding flow states in terms of the directly driven, non-axisymmetric Kelvin mode, the axisymmetric geostrophic mode, and an axisymmetric poloidal flow which is promising for precession-driven dynamo action. The latter issue is discussed with particular view on an optimal parameter choice for the DRESDYN dynamo project.
Biotechnology of biofilms: strategies to control the bacterial community life style (2010)

Trabajo presentado en la 5th International Meeting on Biotechnology (Biospain 2010), celebrada en Pamplona del 29 de septiembre al 1 de octubre de 2010.
The Epidermis (2002)

Various attempts at growing keratinocytes are given in an historical review, with emphasis on the 3T3 feeder layer technique. Protocols are provided for the disaggregation of skin by warm or cold trypsin, and the subsequent culture of epidermal keratinocytes on 3T3 feeder layers. Subculture and the removal of fibroblasts are described, and details given for cryopreservation. The relative merits of culture in selective serum-free media are compared with culture on 3T3 feeder cells. Culture methods for cells derived from keratinocyte tumors are discussed and their resistance to terminal differentiation noted. The chapter concludes with a section on epidermal keratinocyte markers and presents optimal conditions for their induction.
Synthese und Strukturbestimmung eines intramolekular alkylierten, überbrückten Cobaloxims (1976)

Ein überbrücktes Cobaloxim ( 1 ), das zugleich intramolekular am Cobalt‐Atom alkyliert ist, wurde synthetisiert. Nach Auskunft der Röntgenanalyse besitzen die Moleküle keine Symmetrieebene, sondern liegen in chiralen Konformationen vor. magnified image
High Strength Corrosion Resistance Alloy 686 for Seawater Fastener Service (2001)

The excellent corrosion resistance of nickel-alloys has been put to good use in marine engineering for many years. Some applications, such as fasteners, require high levels of strength as well as corrosion resistance. New high strength nickel-alloys and their weldments exhibit excellent resistance to hydrogen embrittlement and seawater corrosion. Solid solution nickel-based alloys such as INCONEL® alloy 686 (UNS N06686) obtain their strength through cold work. Cold worked alloy 686 exhibits excellent resistance to hydrogen embrittlement and corrosion, and exceptional strength, ductility and toughness.
CMOS RF Modeling, Characterization and Applications (2002)

RF MOS measurements, F. Sischka and T. Gneiting MOSFET modelling and parameter extraction for RF IC's, M. Je et al MOSFET modelling for RF IC design, Y. Cheng RF CMOS noise characterization and modelling, C.-H. Chen and M.J. Deen SOI CMOS transistors for RF and microwave applications, D. Flandre et al RF CMOS reliability, S. Naseh and M.J. Deen.
Development of a technique for in situ high temperature TEM observation of catalysts in a highly moisturized air atmosphere (2012)

To clarify the influence of moisture on the structural changes of heated nano materials, in situ high temperature transmission electron microscopy (TEM) has been carried out using a conventional analytical TEM combined with a gas injection-specimen heating holder. Air with high moisture content, above 94% relative humidity (RH), from a humidifier was directly injected onto the heated platinum catalyst dispersed on carbon black (Pt/CB), and the morphological changes of the specimens were observed at high magnification dynamically. The result of the experiment was compared with a result obtained from an experiment using air with a low moisture content, 34% RH. Active movement of the Pt particles, leading agglomeration and grain growth, occurred prior to degradation of the CB support at high moisture content. In contrast, the degradation of the CB support leading agglomeration and grain growth of the Pt particles occurred before the displacement of the Pt particles on the CB supports in a low humidity environment.