gebhart/patrepeval huggingface dataset:
Novel design of a low-cost heterodyne frequency domain-diffuse optical spectroscopy instrument (Conference Presentation) (2023)

Diffuse optical spectroscopy is a widely used method for the non-invasive recovery of important biological factors such as tissue oxygenation and total hemoglobin concentration. Frequency domain-diffuse optical spectroscopy improves the accuracy of parameter recovery over continuous wave-diffuse optical spectroscopy by enabling the decoupling of tissue absorption from tissue scattering. However, this comes at the price of increased instrumentation cost and complexity. Here we detail an easy to build, low-cost, and robust frequency domain-diffuse optical spectroscopy system to increase accessibility to this technology along with testing of the system’s stability and accuracy to ensure its applicability for biological measurements.
LGG-01. DEVELOPMENT OF A WEB-BASED CALCULATOR APPLICATION FOR PREDICTING SHORT- AND LONG-TERMSURVIVAL IN PEDIATRIC OPTIC PATHWAY GLIOMA: A POPULATION-BASED DATABASE ANALYSIS (2023)

Abstract Optic pathway gliomas (OPG) are generally low-grade lesions arising from the astrocytes of the visual pathway, most commonly of the optic nerves and chiasm. Uncertainty remains regarding the optimal management of this patient population. We sought to leverage population-level data from the Surveillance, Epidemiology, and End Results program database to develop a predictive calculator for overall survival (OS) amongst pediatric patients with OPG. A total of 1,052 patients who had been diagnosed with OPG were included. Multivariate cox proportional hazard model demonstrated patients of “other” race (hazard ratio [HR]=4.109, 95% confidence interval [CI] 1.076-15.694, p=0.039) exhibited a decreased overall survival, while patients with a median household income ≥$55,000 (HR=0.172, 95% CI 0.065-0.457, &amp;lt;0.001) and those who underwent subtotal resection (HR=3.549, 95% CI 1.092-13.364, p=0.047) had a higher overall survival rate. An online, interactive survival prediction tool (https://spine.shinyapps.io/optic_glioma/) was created to estimate 5-, 10-, and 15-year overall survival probability as well as median survival months. C-index was 0.722 (95% CI 0.642-0.776) for the training set and 0.745 (95% CI 0.661-0.790) for the validation set. Good concordance between the predicted probability and the actual probability of the dataset was also observed. This calculator may serve as a useful clinical tool during patient counseling. Further investigations aimed at developing calculators of visual acuity preservation and progression-free survival are merited; progress toward this end will benefit from continued multicenter collaborations.
Clinical and Microbiological Effects of Minocycline‐Loaded Microcapsules in Adult Periodontitis (1997)

Clinical and microbiological effects of subgingival delivery of 10% minocycline-loaded (MC), bioabsorbable microcapsules were examined in 15 adult periodontitis patients. Patients received oral hygiene instruction 2 weeks prior to the study. At baseline (day 0) all teeth received supragingival scaling (SC); 2 quadrants received no further treatment and 1 quadrant received subgingival scaling and root planning (SRP). In the fourth quadrant, the tooth with the deepest probing sites (at least 1 site > or = 5 mm) was treated with minocycline microcapsules. The sites were evaluated at baseline and weeks 1, 2, 4, and 6. Clinical indices included bleeding on probing (BOP), probing depths (PD), and attachment loss (AL). Microbiological evaluations included percent morphotypes by phase-contrast microscopy; cultivable anaerobic, aerobic, and black-pigmented Bacteroides (BPB); and percent Porphyromonas gingivalis, Prevotella intermedia, Eikenella corrodens, and Actinomyces viscosus by indirect immunofluorescence. In the SC + MC group, BOP, PD, and AL were significantly reduced from baseline for weeks 1 to 6. BOP in the SC + MC group was significantly reduced compared to the SRP group from weeks 2 to 6. In the SC + MC group the percent of spirochetes and motile rods decreased and the percent of cocci increased after 1 week. The increased cocci and decreased motile rods were statistically greater at weeks 4 and 6 in the SC + MC group compared to the SRP group. This study demonstrates that local subgingival delivery of 10% minocycline-loaded microcapsules as an adjunct to scaling results in reduction in the percent sites bleeding on probing greater than scaling and root planning alone and induces a microbial response more favorable for periodontal health than scaling and root planing.
Inducible over‐expression of cardiac Nos1ap causes short QT syndrome in transgenic mice (2022)

Recent evidence demonstrated that alterations in the QT interval duration on the ECG are not only determined by mutations in genes for ion channels, but also by modulators of ion channels. Changes in the QT interval duration beyond certain thresholds are pathological and can lead to sudden cardiac death. We here focus on the ion channel modulator nitric oxide synthase 1 adaptor protein (Nos1ap). Whole-cell patch-clamp measurements of a conditional transgenic mouse model exhibiting cardiac-specific Nos1ap over-expression revealed a Nos1ap-dependent increase of L-type calcium channel nitrosylation, which led to increased susceptibility to ventricular tachycardias associated with a decrease in QT duration and shortening of APD<sub>90</sub> duration. Survival was significantly reduced (60% after 12 weeks vs. 100% in controls). Examination of the structural features of the hearts of transgenic mice revealed constant heart dimensions and wall thickness without abnormal fibrosis content or BNP production after 3 months of Nos1ap over-expression compared to controls. Nos1ap over-expression did not alter cGMP production or ROS concentration. Our study showed that myocardial over-expression of Nos1ap leads to the shortening of the QT interval and reduces the survival rate of transgenic animals, perhaps via the development of ventricular arrhythmias. We conclude that Nos1ap overexpression causes targeted subcellular localization of Nos1 to the CaV1.2 with a subsequent decrease of ADP<sub>90</sub> and the QT interval. This causes detrimental cardiac arrhythmias in transgenic mice.
Hydrogen Acceptor‐ and Base‐Free N‐Formylation of Nitriles and Amines using Methanol as C1 Source (2015)

Abstract An N ‐formylation method using methanol as the C 1 source without a stoichiometric amount of activating reagent is described. Nitriles as well as amines can be directly used as substrates. The reaction is catalyzed by an N‐heterocyclic carbene coordinated ruthenium(II) dihydride complex, which mediates methanol dehydrogenation, nitrile reduction, and CN bond formation without any external base, hydrogen acceptor, or oxidant. magnified image
Methanol Cross-over in Direct Methanol Fuel Cells (1995)

Transport rates of methanol in ionomer membranes exposed to methanol aqueous solutions were determined electrochemically in cells identical to direct methanol fuel cells (DMFCs) and by NMR measurements on the membrane equilibrated with the methanol solutions. We will compare the electrochemical and NMR results and discuss them in the context of temperature and membrane thickness effects on methanol cross-over in DMFCs. In addition, we show results for CO2 emission from the cathode of an operating DMFC as a function of cell current and methanol concentration in the feed stream, that indicate (1) at low concentrations, methanol cross-over can be lowered by methanol consumption in the anode; and (2) at higher concentrations, methanol is carried across the cell significantly by electroosmosis.
Optical injection in semiconductor ring lasers (2011)

We theoretically investigate optical injection in semiconductor ring lasers and disclose several dynamical regimes. Through numerical simulations and bifurcation continuation, two separate parameter regions in which two different injection-locked solutions coexist are revealed, in addition to a region in which a frequency-locked limit cycle coexists with an injection-locked solution. Finally, an antiphase chaotic regime without the involvement of any carrier dynamics is revealed. Parallels are drawn with the onset of chaos in the periodically forced Duffing oscillator.
Bidirectional AC-DC Converters Using One Cycle Control (OCC) for Electric Vehicles (2016)

Thesis (Master, Electrical &amp; Computer Engineering) -- Queen's University, 2016-07-12 22:55:21.356
Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells (2005)

Our findings show that cag+H pylori cause rapid induction of Egr-1 in gastric epithelial cells which may contribute to H pylori mediated pathogenesis.
Suggesting Design Method for Performance Evaluation System Based on IoT Data: Considering UX (2018)

The rapid development of Internet of Things (IoT) technology makes it possible to connect various objects among each other and to collect sensor data from the objects. Connected car, achieved by advanced driver assistance system (ADAS), is one of the representative example of IoT technology. Since massive amount of IoT data could be effectively analyzed with appropriate methods, it is helpful to introduce supportive systems for the analysis. This study proposes a method to design supportive system for the analysis of IoT data considering user experience (UX). The suggested method is applied to design the supportive system for lane keeping assistance system (LKAS), which is one of the ADAS.
Bacterial, archaeal, and eukaryal diversity in the intestines of Korean people (2008)

The bacterial, archaeal, and eukaryal diversity in fecal samples from ten Koreans were analyzed and compared by using the PCR-fingerprinting method, denaturing gradient gel electrophoresis (DGGE). The bacteria all belonged to the Firmicutes and Bacteroidetes phyla, which were known to be the dominant bacterial species in the human intestine. Most of the archaeal sequences belonged to the methane-producing archaea but several halophilic archarea-related sequences were also detected unexpectedly. While a small number of eukaryal sequences were also detected upon DGGE analysis, these sequences were related to fungi and stramenopiles (Blastocystis hominis). With regard to the bacterial and archaeal DGGE analysis, all ten samples had one and two prominent bands, respectively, but many individual-specific bands were also observed. However, only five of the ten samples had small eukaryal DGGE bands and none of these bands was observed in all five samples. Unweighted pair group method and arithmetic averages clustering algorithm (UPGMA) clustering analysis revealed that the archaeal and bacterial communities in the ten samples had relatively higher relatedness (the average Dice coefficient values were 68.9 and 59.2% for archaea and bacteria, respectively) but the eukaryal community showed low relatedness (39.6%).
Vapor etching of ion tracks in fused silica (2002)

We have used vapor etching of ion tracks to create high aspect ratio (i.e., length much greater than diameter), isolated cylindrical holes through ∼600-nm-thick films of thermally fused silica on silicon. Samples were exposed to the vapor from water-based liquids with various HF and HF+HCl concentrations. Independent control of the temperatures of the vapor and the samples provided the means to vary separately the etching rates for the tracks and the track-free material. The very rapid etching of the small latent track zone can be explained by preferential capillary condensation. Holes with diameters of ∼24 to ∼80 nm have been documented with length/diameter ratios of up to 22. Although we have restricted this study to thin-film silica, we have evidence that such holes are also formed in bulk fused silica.
A Data Base for Arabic Handwritten Text Recognition Research. (2004)

In this paper we present a new database for off-line Arabic handwriting recognition, together with associated preprocessing procedures. We have developed a new database for the collection, storage and retrieval of Arabic handwritten text (AHDB). This is an advance both in terms of the size of the database as well as the number of different writers involved. We further designed an innovative, simple yet powerful, in place tagging procedure for our database. It enables us to easily extract the bitmaps of words. We also constructed a preprocessing class, which contains some useful preprocessing operations. In this paper the most popular words in Arabic writing were identified for the first time, using an associated program.
Molecular clusters of the main group elements (2008)

"To summarize, Molecular Clusters of the Main Group Elements is certainly not a popular science book, nor is it a textbook; it is a very good, up-to-date collection of articles for the specialist.&lt;br /&gt; Als Fazit bleibt: Molecular Clusters of the Main Group Elements ist sicher kein populissenschaftliches Werk, auch kein Lehrbuch, aber eine gelungene, hoch aktuelle Zusammenstellung fen interessierten Fachmann."&lt;br /&gt; -Michael Ruck, TU Dresden, &lt;i&gt;Angewandte Chemie&lt;/i&gt;, 2004 - 116/36 + International Edition 2004 - 43/36
Dynamic Conic Finance: Pricing and Hedging in Market Models with Transaction Costs via Dynamic Coherent Acceptability Indices (2012)

In this paper we present a theoretical framework for determining dynamic ask and bid prices of derivatives using the theory of dynamic coherent acceptability indices in discrete time. We prove a version of the First Fundamental Theorem of Asset Pricing using the dynamic coherent risk measures. We introduce the dynamic ask and bid prices of a derivative contract in markets with transaction costs. Based on these results, we derive a representation theorem for the dynamic bid and ask prices in terms of dynamically consistent sequence of sets of probability measures and risk-neutral measures. To illustrate our results, we compute the ask and bid prices of some path-dependent options using the dynamic Gain-Loss Ratio.
Avian malaria: transmission blocking strategies for the malaria parasite in domestic chicken gallus gallus domesticus and applications for human malaria disease control. (2017)

The malaria disease is caused by the parasitic protozoa in the genusPlasmodium. Of the malaria parasites infecting birds, Plasmodium gallinaceumis the causative agent of the malaria disease in domestic chickens (Gallus gallus domesticus). Infections with P. gallinaceumin domestic chickens may cause severe pathology and death that contributes to substantial economic loss to poultry industry in Thailand. Despite its veterinary significance, P. gallinaceum has shared a number of biological characteristics to the human malaria parasites and has therefore served as a research tool for identification of drug targets and vaccine candidates for the human malaria diseases. The goals of this review were to provide an overview of the life cycle of the avian malaria parasite P. gallinaceum and the progress toward developing transmission blocking strategies for the avian malaria disease. The applications of the transmission blocking tools such as drugs and vaccines for the human malaria diseases were also discussed.
Chipmunk Parvovirus Is Distinct from Members in the Genus Erythrovirus of the Family Parvoviridae (2010)

The transcription profile of chipmunk parvovirus (ChpPV), a tentative member of the genus Erythrovirus in the subfamily Parvovirinae of the family Parvoviridae, was characterized by transfecting a nearly full-length genome. We found that it is unique from the profiles of human parvovirus B19 and simian parvovirus, the members in the genus Erythrovirus so far characterized, in that the small RNA transcripts were not processed for encoding small non-structural proteins. However, like the large non-structural protein NS1 of the human parvovirus B19, the ChpPV NS1 is a potent inducer of apoptosis. Further phylogenetic analysis of ChpPV with other parvoviruses in the subfamily Parvovirinae indicates that ChpPV is distinct from the members in genus Erythrovirus. Thus, we conclude that ChpPV may represent a new genus in the family Parvoviridae.
Combining optical and neural components in physiological visual image quality metrics as functions of luminance and age (2020)

Visual image quality metrics combine comprehensive descriptions of ocular optics (from wavefront error) with a measure of the neural processing of the visual system (neural contrast sensitivity). To improve the ability of these metrics to track real-world changes in visual performance and to investigate the roles and interactions of those optical and neural components in foveal visual image quality as functions of age and target luminance, models of neural contrast sensitivity were constructed from the literature as functions of (1) retinal illuminance (Trolands, td), and (2) retinal illuminance and age. These models were then incorporated into calculation of the visual Strehl ratio (VSX). Best-corrected VSX values were determined at physiological pupil sizes over target luminances of 104 to 10-3 cd/m2 for 146 eyes spanning six decades of age. Optical and neural components of the metrics interact and contribute to visual image quality in three ways. At target luminances resulting in >900 td at physiological pupil size, neural processing is constant, and only aberrations (that change as pupil size changes with luminance) affect the metric. At low mesopic luminances below where pupil size asymptotes to maximum, optics are constant (maximum pupil), and only the neural component changes with luminance. Between these two levels, both optical and neural components of the metrics are affected by changes in target luminance. The model that accounted for both retinal illuminance and age allowed VSX, termed VSX(td,a), to best track visual acuity trends (measured at 160 and 200 cd/m2) as a function of age (20s through 70s) from the literature. Best-corrected VSX(td,a) decreased by 2.24 log units between maximum and minimum target luminances in the youngest eyes and by 2.58 log units in the oldest. The decrease due to age was more gradual at high target luminances (0.70 log units) and more pronounced as target luminance decreased (1.04 log units).
Rapid and Accurate Automatic Temperature Calibration of Disposable Screen-printed Heated Gold Electrodes (2019)

Joule-heated electrodes have been used to enhance electrochemical analysis. Due to such direct heating, a steep temperature gradient is created near the electrode surface. The heating device that provides the high-frequency AC (50 kHz or more) has to be calibrated, in order to apply the desired temperature during analysis. The applied temperature of the working electrode influences both its electrical resistance and the electrochemical potential of a redox couple. Open circuit potentiometric (OCP) measurements were performed automatically with screen-printed gold loop electrodes (Au-LE), while applying 50 kHz AC heating pulses of increasing intensity provided by a ThermaLab® AC generator. Potentiometric temperature calibrations were performed using 5 mM equimolar ferri/ferrocyanide in 0.1 M of potassium chloride at 20 °C bulk temperature. Potential differences produced during each heat pulse were used to automatically calculate the electrode temperature using the temperature coefficient of this redox couple (-1.6 mV/K). The electrode resistance values at each heating pulse were obtained by measuring the heating voltage and heating current. The automatic temperature calibration experiments with five Au-LEs were shown to be highly reproducible and precise, with an RSD for the temperature of 0.24% and 4% for resistance. The average margin error of OCP temperatures were ±0.66 K at a 95% confidence level. The temperature coefficient (α) of electrical resistivity of the screen-printed gold layers was found to be 0.0025 °C&lt;sup&gt;-1&lt;/sup&gt;, which is 27% lower than the theoretical value for gold metal. These findings were confirmed by DC resistance measurements using a potentiostat. Comparing the OCP temperature with the resistivity method, the temperature difference was about 0.94 °C (2.8%). Both methods enable quick, reproducible and accurate temperature calibration for disposable Au-LE, which were also used for trace mercury detection in lake water samples
Pesticide Effect on Faunal Composition, Abundance, and Body Length of Spiders (Araneae) in Apple Orchards (1997)

Journal Article Pesticide Effect on Faunal Composition, Abundance, and Body Length of Spiders (Araneae) in Apple Orchards Get access Joanna Wisniewska, Joanna Wisniewska Department of Entomology, University of Massachusetts, Amherst, MA 01003 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald J. Prokopy Ronald J. Prokopy Department of Entomology, University of Massachusetts, Amherst, MA 01003 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 26, Issue 4, 1 August 1997, Pages 763–776, https://doi.org/10.1093/ee/26.4.763 Published: 01 August 1997 Article history Received: 17 May 1996 Accepted: 28 March 1997 Published: 01 August 1997
A Bio-Economic Feasibility Model For Remote Setting: Potential For Oyster Aquaculture In Virginia (2008)

for their participation in the remote setting program
Pyridinylpiperazines, a new class of selective .alpha.2-adrenoceptor antagonists (1983)

A series of 1-(2-pyridinyl)piperazine derivatives was synthesized and evaluated for adrenergic activity. In vitro activity was assessed through the antagonism of clonidine's effect in the rat, isolated, field-stimulated vas deferens and by the displacement of [3H]clonidine from membrane binding sites of calf cerebral cortex. Antagonism of clonidine-induced mydriasis in the rat was used as an in vivo assay. Several members of the series proved to be potent, selective alpha 2-adrenoceptor antagonists. 1-(3-Fluoro-2-pyridinyl)piperazine was more potent than either yohimbine or rauwolscine in displacement of [3H]clonidine and had a higher affinity for this binding site (alpha 2) than for the [3H]prazosin site (alpha 1). In vivo, the 3-F derivative was more potent than the reference standards in reversing clonidine-induced mydriasis. None of the members of this series was more selective or potent than rauwolscine in antagonizing clonidine in the rat vas deferens.