gebhart/patrepeval huggingface dataset:
Optomechanical Dynamics in Vertical-Cavity Surface-Emitting Lasers (2017)

Vertical-cavity surface-emitting lasers (VCSELs) have emerged as one of the most numerous and diverse categories of semiconductor laser, serving applications in telecommunications, imaging, ranging, and sensing. Improving the behavior of these devices, while extending them into new application spaces, is currently one of the most active fields of optoelectronics research. Concurrently, improvements in micro-optics, micro-mechanics, and low-noise experimentation have produced a field of cavity optomechanics studying the forces of confined light to excite or cool mechanical systems. This thesis explores the interaction of those fields by observing optomechanical forces acting on the MEMS-supported high-contrast grating (HCG) reflector in VCSELs. The unique properties of the HCG as a lightweight, ultra-high-reflectivity mirror enable optomechanical forces to be more salient in these devices than in typical distributed Bragg reflector (DBR) VCSELs. Through optical, electrical, and microscopy characterization methods, we demonstrate the use of radiation pressure to drive the mirror through current modulation and self-oscillation, notably producing a large amplitude oscillation resulting in broad-spectrum self-swept light. By demonstrating optomechanical effects in a single device, we simplify the traditional cavity optomechanics experiment and open a new design space in which to obtain the ingredients necessary for feedback-based optomechanical damping. Looking to both the applications of passive cavity optomechanics and those of wavelength-swept VCSELs, we highlight applications for these phenomena and design and fabrication changes to further explore and harness optomechanical forces in VCSELs. Additionally, we show the development of the first physics-based compact model of VCSELs, which enables simultaneous design of VCSELs and circuits to enhance VCSELs’ performance in communications, ranging, and optomechanics.
The tumor suppression function of p21Waf is contained in its N-terminal half ('half-WAF'). (1995)

The Waf-1 encoded protein, p21, mediates p53 suppression of tumor cell growth. Overexpression of p21 in the H1299 tumor cell line suppresses colony formation similar to that resulted from p53 overexpression. In an effort to localize the tumor suppression function within the structure of p21 we utilized vectors constructed with systematic truncations of p21 and tested their efficiency in suppressing tumor cell growth. We demonstrate that the N-terminal half of the p21 molecule (residues 1-80 and 1-89) shows better tumor cell growth suppression than the entire p21 molecule whereas the C-terminal half of p21 does not show this effect. These results may have implications for gene therapy of cancer.
Influence of Sinusoidally Modulated Visual Stimuli at Extremely Low Frequency Range on the Human EEG Activity (2006)

The purpose of this study was to investigate whether sinusoidally modulated visual stimuli at extremely low frequencies (ELF) of 50, 16.66, 13, 10, 8.33 and 4Hz could influence the changes in EEG activity in 33 human subjects. An improved design of visual stimulator system has addressed an issue of electrical interference from electrical signals driven by LED arrays onto simultaneously recorded EEG. A comparison between 1 and 3-Way ANOVA was performed in order to evaluate whether visual stimuli at ELFs could influence the EEG in humans to compliment the currently active medical research in seasonal affective disorder (SAD) and photic driving. The results revealed that under evaluation of 1 and 3-Way repeated-measures ANOVA tests, the Theta, Alpha2 and Gamma EEG bands exhibited a common significant difference between ELF visual stimuli.
Carbamoylmethylphosphinoxide Derivatives Based on the Triphenylmethane Skeleton. Synthesis and Extraction Properties (2005)

Two different strategies were used to synthesize tri(2-alkoxy-5-nitrophenyl)methanes 6a,b. The X-ray structures of 6a and its precursor 5 show the molecules in a conformation with a syn-orientation of the nitro and alkoxy groups. Hydrogenation and acylation by the appropriate active ester gave the corresponding tri-CMPO derivatives 4a,b. Their ability to complex lanthanide ions was studied by NMR spectroscopy and by nuclear magnetic relaxation dispersion and further characterized by quantum mechanical calculations. Extraction experiments from acidic solution to dichloromethane reveal a reasonable selectivity of Am(III) over Eu(III), but in contrast to similar tetra-CMPOs derivatives of calix[4]arenes the distribution coefficients strongly decrease with increasing concentration of HNO(3).
에니어그램과 의식의 발달 수준 (2016)

Purpose: The purpose of this study was to investigate the development levels of human`s consciousness. To achieve the goal, Following research questions were established: 1) To investigate Maslow`s theory of the hierarchy of needs in humanistic perspective. 2) To investigate the development levels of the Enneagram. In the Enneagram, this study has tried to investigate Gurdjieff`s and Riso`s levels of development. 3) to understand the integrated approach of the levels of development on the Enneagram and Maslow`s theory. Methods: This study is based on literature review. Results: The results of this research are follow. Firstly, it is possible for a person to grow higher consciousness and to elaborate the development levels with comprehending the developmental levels in the Enneagram and Maslow`s theory. Secondary, the Enneagram is to be used not only as a tool which classifies the types of personality in the horizontal view but also as an instruction in the vertical view through witch a person attains self-development and ultimately achieves one`s spiritual growth. Conclusion: In integrating the development levels of the Enneagram and Maslow`s theory, this study will be used as a guide with which counselors, therapists and individuals are interested in spiritual growth and investigate the human growth.
Urban Form and Climate: Case Study, Toronto (1995)

Abstract Abstract This article describes a joint urban design study by the Berkeley Environmental Stimulation Laboratory and the Centre for Landscape Research at the University of Toronto. The study analyzed the effect of future development in Toronto's Central Area on street-level conditions of sun, wind, and thermal comfort. The study originated in response to public concern about the quality of the downtown environment and to implementation measures adopted by the Toronto city council in May 1993. The research presented in this article examines the shadowing produced by downtown buildings and recommends procedures and standards for preserving sunlight on Toronto's downtown sidewalks and open spaces. Second, this study considers the effects of buildings on wind conditions at street level. Third, the study evaluates the combined effects of sun and wind conditions on pedestrian comfort. Rather than focusing on just the effects of individual buildings, this research evaluates the cumulative effects of area-wide development.
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system (2020)

Cardiac disease is a frequent and significant adverse event associated with radiotherapy for cancer. Identifying the underlying mechanism responsible for radiation injury to the heart will allow interventions to be developed. In the present study, we tested if local kidney irradiation results in remodeling of the shielded, nontargeted heart. One kidney, two kidneys, or the total body of male WAG and Dahl SS rats were irradiated with 10 Gy of X-rays. Local kidney irradiation resulted in systemic hypertension, increased BUN, infiltration of T lymphocytes, natural killer cells, and macrophages into the renal cortex and medulla, and renal fibrosis. Local irradiation of kidneys in WAG rats resulted in remodeling in the nontargeted heart after 120 days, manifested by perivascular fibrosis and increased interventricular septal thickness, but was not seen in Dahl SS rats due to a high baseline level of fibrosis in the sham-irradiated animals. Genetic depletion of T cells mitigated the nephropathy after local kidney irradiation, indicating a role for the immune system in mediating this outcome. Local kidney irradiation resulted in a cascade of pro-inflammatory cytokines and low-molecular weight metabolites into the circulation associated with transmission of signals resulting in pathologic remodeling in the nontargeted heart. A new model is proposed whereby radiation-induced cardiac remodeling in susceptible animals is indirect, with lower hemi body organs such as the kidney exporting factors into the circulation that cause remodeling outside of the irradiated field in the shielded, nontargeted heart. This nontargeted effect appears to be mediated, in part, by the immune system.
Development of substrate integrated waveguide power dividers (2004)

Two classes of substrate integrated waveguide (SIW) power divider are presented, namely, Y- and T-types. Using arrays of via, the SIW power dividers and microstrip transitions are integrated on the same substrate. Design models are presented respectively for the Y- and T-junctions. Experimental results over the Ka band are given for both structures. The Y-junction shows a bandwidth of 25.2% at -18.5 dB while the T-junction shows a bandwidth of 10.2% at -19.0 dB.
High Quality SiC Crystals Grown by the Physical Vapor Transport Method with a New Crucible Design (2006)

SiC single crystal ingots grown by sublimation physical vapor transport (PVT) technique were prepared and then the SiC crystal quality with varying crucible design employing a guide tube and tantalum foil was systematically investigated. The growth rate of 2-inch SiC crystal grown by these crucible designs was about 0.3 mm/hr. The n-type and p-type 2”-SiC single crystals exhibiting the polytype of 6H-SiC were successfully fabricated. The doping concentration level of below ~1017/cm3 was extracted from the absorption spectrum and Hall measurement. The densities of micropipes and inclusions in SiC crystal boules grown using the graphite/Ta foil double layer guide tube were significantly decreased. Finally we improved crystal quality through the introduction of new crucible design.
Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia (2023)

&lt;p&gt;Transcription Factor Enrichment Analysis of MOLM13 Bulk RNA-Seq (24 Hours After Drug Treatment)&lt;/p&gt;
Independence of Contour and Biological-Motion Cues for Motion-Defined Animal Shapes (1998)

The effects of different kinds of cues on the perception of second-order motion-defined animal shapes were assessed. In the first experiment discrimination thresholds for motion-defined animals without biological motion (non-BioM) were compared with motion-defined animals with biological motion (BioM). The results show no significant difference between the two conditions, suggesting that BioM does not interact with simple contour motion. In order to isolate the relative strength and interaction between the motion cues a second experiment was conducted where four conditions were used. The first condition consisted of animal contours with non-BioM, the second condition consisted of animal contours with BioM, the third condition was composed of dots present at the joints of the animals with non-BioM, and the fourth condition was composed of dots with BioM. In all cases the animal shapes traveled across the screen for a given number of frames. As in the first experiment, the results of the second study show no interaction between cues. Furthermore, the data show that the thresholds are similar whether BioM or contour cues are presented. The only condition which is significantly different is the condition without either contour or BioM cues. It is concluded that the form representation generated from these cues in motion-defined animal shapes consists of separate mechanisms which appear equally efficient for discrimination and which do not interact with one another.
A MEQ-Deleted Marek's Disease Virus Cloned as a Bacterial Artificial Chromosome Is a Highly Efficacious Vaccine (2010)

The Marek's disease virus (MDV) induces T-cell tumors in susceptible chickens. Of the 80 to 100 known MDV genes, only the MDV MEQ gene was shown to have transforming properties. Further evidence that MEQ is probably the principal oncogene in MDV came when researchers used overlapping cosmid clones of MDV and demonstrated that deleting MEQ resulted in a highly protective Marek's disease (MD) vaccine. We deleted both copies of MEQ from a bacterial artificial chromosome clone (BAC) of MDV. The virus, BACdelMEQ, was completely attenuated and did not appear to have any adverse effect on chicken body weight in MDV maternal-antibody-positive chickens, as measured at 8 wk of age. In two protection studies, BACdelMEQ efficiently protected susceptible chickens from a challenge by MDV strain 686, one of the most virulent MDV strains. In both protection studies, the BACdelMEQ protected chickens significantly better than the commercial MD vaccine, CVI988/Rispens. Only the protein-coding sequences of MEQ were deleted and all upstream and downstream regulatory sequences were left intact. Thus, BACdelMEQ has the potential to be a superior MD vaccine as well as a vector to deliver various foreign genes to poultry.
Neuropharmacological profile of 1-azaphenothiazine-10-thiolcarboxylates (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNeuropharmacological profile of 1-azaphenothiazine-10-thiolcarboxylatesEdward R. Atkinson, Pamela L. Russ, Margaret A. Tucker, and Franklin J. RosenbergCite this: J. Med. Chem. 1971, 14, 10, 1005–1007Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jm00292a038https://doi.org/10.1021/jm00292a038research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-Related Disorders (2006)

Mitochondrial diseases are a diverse group of disorders characterized by impairment of mitochondrial function. The diversity is most easily seen in the bewildering array of clinical phenotypes that result from errors not only in maternally inherited mitochondrial DNA (mtDNA) and mendelian-inherited nuclear DNA (nDNA), but also from spontaneous mutations and environmental insults that can affect either genome. The human mitochondrial genome is a 16,569-bp double-stranded DNA circle (Anderson et al., 1981). It contains only 37 genes (Fig. 1): two encode ribosomal RNAs, 22 encode transfer RNAs, and 13 encode polypeptides. Significantly, all 13 polypeptides are components of the respiratory chain/oxidative phosphorylation system. They include seven subunits of complex I (NADH dehydrogenase–ubiquinone oxidoreductase), one subunit of complex III (ubiquinone–cytochrome c oxidoreductase), three subunits of complex IV (cytochrome c oxidase), and two subunits of complex V (ATP synthetase). The respiratory complexes also contain subunits encoded by nuclear DNA (nDNA) imported into the organelle from the cytosol and co-assembled with the mtDNAencoded subunits into their in respective complexes in the mitochondrial inner membrane.
On the nonlinear deterministic and stochastic dynamics of a cable - mass system with time-varying length (2017)

Nonlinear deterministic and stochastic oscillations of a moving long slender continuum (LSC) carrying a concentrated inertia element is analyzed. When the system is subjected to external excitations transient resonance and modal interactions occur. These phenomena can be studied by using a stochastic linearised model of the system comprising cable carrying a concentrated mass.
In Vitro and In Vivo Degradation of Glucose Oxidase Enzyme Used for an Implantable Glucose Biosensor (2000)

The presence of glucose in vitro and in vivo led to the production of H2O2, suggesting this to be the main agent responsible for enzyme degradation. The use of a Nafion coating did not provide any additional protection.
Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016 (2019)

Active surveillance for candidemia yielded important information about the disease incidence and death rate and persons at greatest risk. The surveillance was expanded to nine sites in 2017, which will improve understanding of the geographic variability in candidemia incidence and associated clinical and demographic features. This surveillance will help monitor incidence trends, track emergence of resistance and species distribution, monitor changes in underlying conditions and predisposing factors, assess trends in antifungal treatment and outcomes, and be helpful for those developing prevention efforts. IDU has emerged as an important risk factor for candidemia, and interventions to prevent invasive fungal infections in this population are needed. Surveillance data documenting that approximately two thirds of candidemia cases were caused by species other than C. albicans, which are generally associated with greater antifungal resistance than C. albicans, and the presence of substantial fluconazole resistance supports 2016 clinical guidelines recommending a switch from fluconazole to echinocandins as the initial treatment for candidemia in most patients.
Integration of Digital Earth and physics engine for spatial simulation (2013)

The spatial simulation such as one of the landslide may play an important part for research, decision-making or forecast of spatial variation. Digital Earth (DE) can be become a very useful platform for the spatial simulation. Google Earth, very successful use case for DE, is very useful platform for visualizing geo-referenced data, but limited for the spatial simulation. In the paper, a method for integration of DE and a physics engine was proposed. The proposed method simulates a spatial change by the local physics engine and combines the simulation result with images of DE on online. The paper presents simple landslide simulation by the simple integration software, implemented by the proposed method.
Platform for an open architecture controller based on a general operation system with a hard real-time extension (2003)

A new open architecture controller, Platform for Open Architecture Controller (POAC), is discussed. Using a general operating system with a hard real-time extension, POAC divides the application software of the controller into the developing and application systems. The developing system includes the function subsystem and communication subsystem, which respectively realize the function module capable of running on the different operating systems and the communication interface uniform to all kinds of operating systems. The application system defines the model of the task module, realizing the interoperability and interchangeability between the task modules. POAC establishes a modular developing method and implements the real-time and non-real-time functions separately. The comparison with Next Generation Controller (NGC), the Open System Architecture for Controls within Automation Systems (OSACA), the Open, Modular Architecture Controls (OMAC) and the Open System Environment for Controller (OSEC) shows that POAC is a good, open architecture controller with the advantages of real-time performance, simplicity and practicability. In summary, POAC develops a simple and practical architecture and a standard of open architecture controller that largely decreases the developing time from the standard to the product.
ChemInform Abstract: Asymmetric Synthesis of anti‐β‐Hydroxy‐α‐amino Acids. (1987)

Abstract The N‐haloacetyloxazolidinones (I) are stereoselectively coupled with the aldehydes (II) in the presence of dibutylboryl trifluoroacetate (III), producing the derivatives (IV).
Surface Modification of Fluorinated Polymers by Microwave Plasmas (1990)

Abstract We developed a new plasma treating method, incorporating the use of microwaves generated by an electronic cooking range. Using this method, polytetrafluorethylene (PTFE) and a copolymer of tetrafluoroethylene and hexafluoropropylene (FEP) were treated. Dialkylphthalates (DAP) were used as the standard liquids of contact angle measurements for evaluation of the wetting properties of plasma treated polymers. The components of surface tension (γL) due to the dispersion force (γd L) and the polar force (γP L) of DAP were calculated by Fowkes' equation from the contact angles (θ) on polypropylene. After plasma treatment cos θ of several standard liquids on PTFE and FEP increased. The linear relationship between γL(1 + cos θ)/(γd L)½ and (γP L/γP L)½ was verified. γs and γd s and γd s of the plasma treated PTFE and FEP also increased. From the results of ESCA analysis, it was found that a significant amount of oxygen was introduced to the polymer surface by the plasma treatment. Peel strengths of a pressure sensitive adhesive bonded to PTFE and FEP increased approximately two-to threefold if the plasma treatment was used prior to bonding. Key Words: Fluorinated polymersmicrowave plasmassurface modificationcontact angleswettingpeel strength
To Clot or Not To Clot (2006)

Purpose: Many patients with gastroparesis require sustained central IV access for hydration, medication, and/or nutrition. A recent report has shown that over 90% of gastroparetics are hypercoaguable. We studied a group of patients with gastroparesis and prolong IV access to identify factors associated with an increased risk of catheter related thrombosis. Methods: We analyzed serum coagulation studies and autoimmune antibodies in 53 consecutive patients with gastroparesis and central IV access. This patient group fell into two catergories: those who formed clinically significant line related thrombosis (CLOT) and those that did not (NOCLOT). Data was then statistically compared between the two groups. Results: We found patients in the CLOT group had higher titers of Scl 70 antibodies than the NOCLOT group. Also, our study revealed that higher titers of Ku 66 antibodies were present in the NOCLOT group as compaired to the CLOT group. There was no significant difference between the two groups when comparing other autoantibodies {See Table 1} nor other serum coagulation factors {See Table 2}.Table: Autoimmune Markers in the CLOT and NOCLOT Groups.Table: Coagulation Studies in the CLOT and NOCLOT Groups.Conclusions: We conclude that the patients that formed thromboses had significantly higher serum titers of Scl 70 antibodies, and those that did not had higher titers of Ku 66 antibodies. These findings suggest autoimmune factors may play a role in thrombosis in patients with gastroparesis and in the future may be used to risk stratify these patients for line-related thrombosis.