gebhart/patrepeval huggingface dataset:
Source VUV pour les dépots photochimiques de couches mincesdiélectriques (1994)

Les techniques de dpt de couches minces assistes par rayonnement UV et VUV ont t tudies afin de dvelopper une technologie a faible budget thermique pour l'optolectronique. Une lampe Kr clairs de forte puissance mettant dans 1' VUV-UV-VIS-IR a t optimise pour permettre grce son spectre tendu et plus particulirement grce aux longueurs d'ondes VUV comprises entre 170 et 250 nm de dcomposer efficacement les prcurseurs gazeux conduisant la formation de dilectriques base de silicium. La luminance de ces lampes au taux de rptition de 1 Hz dans cette rgion VUV est de 42 mw/cm2.sr*. Grce cette source, il est possible de dposer la silice et le nitrure de silicium des tempratures proche de l'ambiante. L'interaction de ce rayonnement avec une phase solide et non plus gazeuse a t galement tudie. L'irradiation d'une couche mince dilectrique contenant des liaisons hydrogne a conduit la disparition lente de ces liaisons. Cette irradiation ralise froid a t dnomm "recuit UV" car elle provoque une volution des proprits structurelles de ces couches minces dilectriques quivalente celle qu'un recuit thermique provoquerait
Preparation of SilicoBoron CarboNitride fibers from inorganic polymers (2008)

International audience
Polysemy: Theoretical and Computational Approaches (2000)

1. Polysemy: An overview 2. Aspects of the Micro-Structure of Word Meanings 3. Autotroponomy 4. Lexical Shadowing and Argument Closure 5. Describing Polysemy: The case of 'Crawl' 6. 'The Garden Swarms with Bees' and the Fallacy of 'Argument Alternation' 7. Polysemy: A problem of definition 8. Lexical Representations for Sentence Processing 9. Large Vocabulary Word Sense Disambiguation 10. Polysemy in a Broad-Coverage Natural Language Processing System 11. Disambiguation and Connectionism
Selective area chemical vapor deposition of graphene (2018)

For more than half a century silicon-based CMOS transistors have been scaled continuously to fulfill the projections of Moore’s law and served as the backbone of semiconductor electronics. This scaling trend, however, is now approaching fundamental limits on computing speed and energy efficiency. Due to their unique properties, two dimensional (2D) materials, especially graphene and transition metal dichalcogenides (TMDCs), offer great opportunities for developing “beyond CMOS” electronic devices and other future electronic and photonic devices. However, there are still several critical challenges for graphene applications, such as mass production of high-quality single-crystal graphene films, bandgap opening, and heterostructure integration with other 2D materials. Chemical vapor deposition (CVD) of graphene is the most promising way by far for the synthesis of large-scale single-crystal graphene. In this dissertation, we study the low-pressure chemical vapor deposition (LPCVD) of graphene on commercial copper foils and develop a new graphene growth method called selective area chemical vapor deposition of graphene (SACVD). This SACVD method is a one-step seed-free method that can synthesize graphene on selective areas of the copper catalytic substrate by using a quartz mask. We study the growth model of the SACVD graphene growth and propose a growth mechanism to understand the SACVD growth of graphene. In SACVD graphene grows on both the front and back sides of the Cu foil that is sandwiched between the quartz mask and substrate. Furthermore, the graphene that grows on both sides of the copper foil shares the same pattern as defined by the smaller topside quartz mask. Based on this experimental observation, the proposed mechanism is that the oxygen released by the fused quartz accumulates sufficiently to promote graphene growth only in the regions where both sides of the copper foil are masked by quartz. The high diffusion coefficient of oxygen through copper would prevent this accumulation if fused quartz were placed on only one side of the copper foil. This SACVD method can be applied to the growth of an ordered array of large-size single-crystal graphene domains, and potentially to the growth of other 2D materials. Based on the SACVD growth of single crystal graphene, we also propose a continuous growth method to grow large-size single-crystal graphene controlled by a moving quartz mask. To pattern graphene at the nanoscale for bandgap opening and device fabrication, we also study atomic force microscope tip-based nanolithography methods and find that different types of localized chemical reactions, such as electrochemical oxidation and catalytic etching, can be induced by AFM tips under different conditions.
Diamine and Triamine Analogs and Derivatives as Inhibitors of Deoxyhypusine Synthase: Synthesis and Biological Activity (1995)

Deoxyhypusine synthase catalyzes the initial step in the posttranslational formation of the amino acid hypusine [N epsilon-(4-amino-2-hydroxybutyl)lysine] in eukaryotic initiation factor 5A (eIF-5A). eIF-5A and its hypusine modification are believed to be essential for cell growth. A number of compounds related to diamines and triamines were synthesized and tested as inhibitors of this enzyme. The findings indicate that the long chain triamines 2a and 2b and their guanyl derivatives 3a, 3b, 4a, and 4b exert inhibition by binding to enzyme through only a portion of their structures at any one time. The inhibition exhibited by N-ethyl-1,7-diaminoheptane 20 and its guanyl derivative 21 supports this notion and is evidence for participation of the secondary amino group in binding to enzyme. There is preliminary evidence that amidino and isothiuronium groups may also serve as basic centers for binding to enzyme. Few of the compounds tested here were comparable in inhibitory potency to 1-guanidino-7-aminoheptane (GC7) the most effective known inhibitor of deoxhypusine synthase, and none proved nearly as efficient as GC7 in inhibiting the enzyme in Chinese hamster ovary cells. Hence, unlike the antiproliferative effect of GC7, for which there is evidence of cause by interference with deoxhypusine synthase catalysis (Park, M. H.; Wolff, E. C.; Lee, Y. B.; Folk, J. E. J. Biol. Chem. 269, 1994, 27827-27832), the effective growth arrest exerted by several of the newly synthesized compounds cannot be attributed to inhibition of hypusine synthesis.
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity (2018)

Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of <i>KCNJ10,</i> which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive neurological decline. We investigated Kir4.1 functions in oligodendrocytes (OLs) during development, adulthood and after WM injury. We observed that Kir4.1 channels localized to perinodal areas and the inner myelin tongue, suggesting roles in juxta-axonal K<sup>+</sup> removal. Conditional knockout (cKO) of OL-<i>Kcnj10</i> resulted in late onset mitochondrial damage and axonal degeneration. This was accompanied by neuronal loss and neuro-axonal dysfunction in adult OL-<i>Kcnj10</i> cKO mice as shown by delayed visual evoked potentials, inner retinal thinning and progressive motor deficits. Axon pathologies in OL-<i>Kcnj10</i> cKO were exacerbated after WM injury in the spinal cord. Our findings point towards a critical role of OL-Kir4.1 for long-term maintenance of axonal function and integrity during adulthood and after WM injury.
Evaluation and Selection of A Non-PCR Based Technology for Improved Gene Expression Profiling from Clinical Formalin-Fixed, Paraffin-Embedded Samples (2016)

Quantitative nuclease protection assay represents an improved methodology for detecting gene expression in FFPE tissue and has the potential to advance the development of cancer biomarkers.
Efficacy of Anti-RON Antibody Zt/g4–Drug Maytansinoid Conjugation (Anti-RON ADC) as a Novel Therapeutics for Targeted Colorectal Cancer Therapy (2014)

Zt/g4-DM1 is highly effective in targeted inhibition of CRC cell-derived tumor growth in mouse xenograft models. This work provides the basis for development of humanized Zt/g4-DM1 for RON-targeted CRC therapy in the future.
Supplementary Figure 7 from Vascular Endothelial Growth Factor-C Protects Prostate Cancer Cells from Oxidative Stress by the Activation of Mammalian Target of Rapamycin Complex-2 and AKT-1 (2023)

Supplementary Figure 7 from Vascular Endothelial Growth Factor-C Protects Prostate Cancer Cells from Oxidative Stress by the Activation of Mammalian Target of Rapamycin Complex-2 and AKT-1
Molecular and Physiological Responses of Two Classes of Marine Chromophytic Phytoplankton (Diatoms and Prymnesiophytes) during the Development of Nutrient-Stimulated Blooms (2000)

Generic taxon-specific DNA probes that target an internal region of the gene (rbcL) encoding the large subunit of ribulose-1, 5-bisphosphate carboxylase/oxygenase (RubisCO) were developed for two groups of marine phytoplankton (diatoms and prymnesiophytes). The specificity and utility of the probes were evaluated in the laboratory and also during a 1-month mesocosm experiment in which we investigated the temporal variability in RubisCO gene expression and primary production in response to inorganic nutrient enrichment. We found that the onset of successive bloom events dominated by each of the two classes of chromophyte algae was associated with marked taxon-specific increases in rbcL transcription rates. These observations suggest that measurements of RubisCO gene expression can provide an early indicator of the development of phytoplankton blooms and may also be useful in predicting which taxa are likely to dominate a bloom.
Maxillary osteonecrosis after denosumab treatment (2018)

A 58-year-old patient with a history of intravenous use of denosumab was referred to the department of oral and maxillofacial surgery with inadequate recovery after a series of extractions. During physical and radiological examination, several sites of exposed necrotic bone with purulent discharge were seen, and the maxilla appeared fractured at the level of Le Fort 1. Treatment consisted of intravenous administration of antibiotics with consecutive sequestrectomy of the maxilla under general anaesthesia. While Medication Related Osteonecrosis of the Jaw (MRONJ) is most commonly seen in patients treated with bisphosphonates, in the past decade, it has become apparent that other types of medication, most notably denosumab, can cause comparable disorders. Treatment of MRONJ strongly depends on the stage the disease is in. In patients with a history of denosumab or bisphosphonate use (administered either intravenously or orally in combination with corticosteroids), abnormal radiological findings, or developing osteonecrosis, referral to a department of oral and maxillofacial surgery is recommended.
On the Impact of Blackhole-Attack Variations on ML-based Intrusion Detection Systems in IoT (2023)

Intrusion detection systems (IDS) are crucial components in a defense strategy for IoT networks, as such networks have applicability in safety-critical environments such as healthcare, manufacturing, and smart cities, to name but a few. A promising approach is to train IDS models using machine learning (ML) with data from previous attacks. Unfortunately, the models are only as good as the data provided in the training, and often access to realistic attack data is limited. In this paper we focus on Blackhole attacks in low-power and lossy IoT networks. Specifically, we study the impact of Blackhole attack variations on a ML-based IDS. We implemented the variation strategies in the Cooja network simulator, with the objective to create new data sets and to quantity the impact of an attack variation on the network and IDS model performance. Our initial results show that variations of the Blackhole attack have a negative impact on the performance of the IDS, and thus, paves the way forward for further research on how attack variations and corresponding data set complexity can improve the performance of an IDS.
Telepresence technology in medicine: principles and applications (1998)

Telepresence systems can improve surgeons' performance in minimally invasive surgery (MIS) and microsurgery and also enable them to operate on patients remotely over great distances. In MIS, telepresence technology allows surgeons to experiment surgery as if their hands and eyes were effectively inside the patient's closed abdomen, enabling them to work with improved skill and dexterity. In microsurgery, the technology can scale down the surgeons' motions, forces, and field of view, allowing them to skillfully operate on microscopic anatomy with relative ease. The systems also enable surgeons to treat patients remotely in inaccessible or hazardous locations with great effectiveness, allowing them to operate as if they were present at the remote site. The means for conveying human presence in such systems is through force-reflecting manipulators with digital servo controllers, stereo viewing systems, and communication links. Depending on the application, the surgeon at the telepresence workstation may be across the room from the patient or across the state, connected by a microwave link or communication network.
Novel Si-based nanowire devices: Will they serve ultimate MOSFETs scaling or ultimate hybrid integration? (2008)

Both CMOS scaling and NEMS sensor devices scaling converge to the same type of sub 100 nm objects. This opens new fields of application for IC chips integrating both complex signal treatment and very highly sensitive sensing functionalities.
Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy (1999)

Management of severe acute asthma attacks in children sometimes bring difficulties to the physician. Some current treatment strategies have focused on intravenous magnesium sulphate administration in patients nonresponding to therapy with beta-2 agonists and corticosteroids. The use and efficacy of this drug has been discussed in this randomized, double-blind, placebo-controlled clinical trial consisting of 20 children with moderate to severe acute asthma exacerbation admitted to the emergency department in Dicle University Hospital, Turkey. Magnesium sulphate infusion therapy of 40 mg/kg doses (maximum 2 g) or an equivalent volume of normal saline solution were administered to randomly assigned 10 patients in each group to the selected patients who were being treated for an acute asthma exacerbation with a peak expiratory flow rate (PEFR) less than 60% of the predicted value after receiving three beta-2 adrenergic nebulizer treatments (salbutamol) given at an interval of 20 minutes each. Vital signs, PEFR and physical examinations were serially recorded at 15 minutes intervals for a total of 90 minutes after the initiation of magnesium sulphate therapy. At 30 minutes, compared with the placebo group, the magnesium sulphate receiving group had lower clinical asthma scores (4.0+/-0.5 vs. 5.5+/-0.5, p = 0.0002) and a significantly greater percentage of improvement from baseline in PEFR (43.0+/-6.3% vs. 14.6+/-3.7%, p = 0.0002). These significant changes persisted at 45, 60, 75 and 90 minutes. No significant side effects were observed. In conclusion, severe asthmatic cases may benefit from magnesium sulphate therapy when beta-2 agonists are inadequate in preventing deterioration.
Visual cortical circuits revealed using fMRI and ICA (2010)

This research used the Infomax ICA algorithm to search for independent circuits within the functional activity evoked during saccadic and vergence tracking fMRI experiments. Image processing determined independent components from each subject's data and then identified which components had high correlation between subjects. Using the individual independent components that had high correlation between subjects, a group ICA was performed. The temporal properties between ROIs were then examined. The results of this study indicated that there are two separate spatial pathways; fronto-parietal and cerebellum, involved in oculomotor tracking tasks and the cerebellar pathway was delayed compared to the fronto-parietal component.
Pore-scale simulation of fluid flow and solute dispersion in three-dimensional porous media (2014)

In the present work fluid flow and solute transport through porous media are described by solving the governing equations at the pore scale with finite-volume discretization. Instead of solving the simplified Stokes equation (very often employed in this context) the full Navier-Stokes equation is used here. The realistic three-dimensional porous medium is created in this work by packing together, with standard ballistic physics, irregular and polydisperse objects. Emphasis is placed on numerical issues related to mesh generation and spatial discretization, which play an important role in determining the final accuracy of the finite-volume scheme and are often overlooked. The simulations performed are then analyzed in terms of velocity distributions and dispersion rates in a wider range of operating conditions, when compared with other works carried out by solving the Stokes equation. Results show that dispersion within the analyzed porous medium is adequately described by classical power laws obtained by analytic homogenization. Eventually the validity of Fickian diffusion to treat dispersion in porous media is also assessed.
Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro (1992)

Acquired immunodeficiency syndrome (AIDS) is frequently associated with dementia. The wide spectrum of neurological abnormalities associated with this dementia may involve a neurotoxin that activates the NMDA subtype of glutamate receptor in neurons. We have found that the antimicrobial agent pentamidine, which is prescribed for AIDS patients for the prophylaxis and treatment of Pneumocystis carinii pneumonia, is an effective NMDA receptor antagonist. Pentamidine inhibited 3H-dizocilpine binding to the NMDA receptor in rat brain membranes at a site separate from glutamate, glycine, and spermidine, with an affinity near 2 microM. Similar concentrations of pentamidine block NMDA-induced increases in intracellular Ca2+ and NMDA-induced currents in cultured forebrain and cortical neurons, apparently without use dependence or voltage dependence, suggesting that pentamidine may represent a novel chemical class of NMDA receptor antagonist. Finally, pentamidine protects neurons from the lethal effects of acute NMDA exposure in vitro. AS pentamidine may accumulate in the brain at relevant concentrations following repeated high-dose parenteral administration, these findings suggest that the drug may be neuroprotective in vivo.
Dithering of First-Order Sigma-Delta Modulators (1994)

A new dithering method to remove pattern-noise peaks in ?? modulators is presented. In the new method, the digital decimation filter is matched to the dither which results in total elimination of the dither power. With respect to existing dithering techniques, the decrease in dynamic range inside the loop filter is negligible because little dither power is required (≪30% FS). Experiments with a transducer interface IC in a 3?m BiCMOS technology prove good agreement with the theory. Adding only little hardware results in an improvement in the integral non-linearity from 13 bits to the 16 bits level.
Mucosal and systemic antiviral antibodies in mice inoculated intravaginally with herpes simplex virus type 2 (1990)

Herpes simplex virus type 2 (HSV-2) causes lethal illness after intravaginal (IVAG) inoculation into BALB/cJ mice. In the present studies, we demonstrated in mice that primary IVAG vaccination with an attenuated strain of HSV-2 induced humoral immunity in sera and in vaginal secretions. Secondary genital exposure to HSV-2 enhanced this response. However, intraperitoneal exposure to attenuated HSV-2 elicited an antiviral antibody response in sera but not in vaginal secretions. In both sera and vaginal secretions, antiviral IgG antibodies were the major isotype. Systemic exposure to HSV-2 elicited antibodies only in sera that were specific for the major viral antigens whereas IVAG inoculation with HSV-2 stimulated both serum and vaginal antibody responses. Intravenous transfer of antiviral monoclonal antibodies protected against systemic HSV-2 infection but were ineffective against vaginal infection due to a lack of transudation into vaginal secretions. These results suggested that local humoral immunity in the genital tract is important in resistance to HSV-2.
LEDA-F Storage Ring Dedicated to the Free Electron Laser Operation. Preliminary Design (1979)

The preliminary design of an electron storage ring dedicated to the free electron laser operation, is presented. The main feature of the proposed laser is the complete tunability in the wavelength range 0.3 μm < λ < 20 μm with an output average power of the order of 1 kW and an efficiency, electron beam-laser beam, of ~ 2%.
Loop mediated isothermal amplification (LAMP) for rapid detection of HBV in Iran (2009)

Hepatitis B virus (HBV) is one of the most important factors for hepatocellular carcinoma and a liver disease that seems 350 - 400 million persons are infected with all over the world. Loop mediated isothermal amplification (LAMP) is a novel nucleic acid amplification technique with high specificity and sensitivity which has been done under isothermal condition. In this study we tried to apply LAMP technique for rapid, accurate, and cost-effective diagnosis of HBV in patient's serum samples. 104 HBV quantities sera were supplied. Six LAMP specific primers were designed for HBs region of HBV. LAMP and PCR reactions were optimized. At the end of the LAMP reaction, SYBR Green was used for identifying negative and positive results. The PCR sensitivity up to 40 particles was observed and the LAMP sensitivity test was verified up to 4 particles. Among the 104 quantities sera, only 95 cases were PCR positive but 101 cases were LAMP positive. 9 cases were PCR negative among these, 6 cases were reported as LAMP positive. In 3 cases LAMP and PCR were both negative. In comparison, between LAMP and PCR, the LAMP technique in spite of its simplicity, high sensitivity and specificity, could be an appropriate replacement for PCR.

	                                                  

	Key word: Hepatitis B, PCR, LAMP.