gebhart/patrepeval huggingface dataset:
N-Terminally Modified Linear and Branched Spermine Backbone Dipeptidomimetics against Planktonic and Sessile Methicillin-Resistant Staphylococcus aureus (2014)

Toward the discovery of useful therapeutic molecules, we report the design and synthesis of a focused library of new ultrashort N-terminally modified dipeptidomimetics, with or without modifications in the spermine backbone leading to linear (series 1) or branched (series 2) tryptophans, as antimicrobial agents. Eight peptidomimetics in the library showed good antibacterial activity (MICs of 1.77 to 14.2 μg/ml) against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis bacterial strains. Tryptophan fluorescence measurements on artificial bacterial or mammalian mimic membranes and assessment of the MRSA potential depolarization ability of the designed compounds revealed membrane interactions dependent on tryptophan positioning and N-terminal tagging. Among active peptidomimetics, compounds 1c and 1d were found to be nonhemolytic, displaying rapid bactericidal activity (at 4× MIC) against exponentially growing MRSA. Further, scanning electron microscopy of peptidomimetic 1c- and 1d-treated MRSA showed morphological changes with damage to cell walls, defining a membrane-active mode of action. Moreover, peptidomimetics 1c and 1d did not induce significant drug resistance in MRSA even after 17 passages. We also investigated the activity of these molecules against MRSA biofilms. At sub-MIC levels (∼2 to 4 μg/ml), both peptidomimetics inhibited biofilm formation. At concentrations higher than the MIC (35 to 140 μg/ml), peptidomimetics 1c and 1d significantly reduced the metabolic activity and biomass of mature (24-h) MRSA biofilms. These results were corroborated by confocal laser scanning microscopy (live/dead assay). The in vitro protease stability and lower cytotoxicity of peptidomimetics against peripheral blood mononuclear cells (PBMCs) support them being novel staphylocidal peptidomimetics. In conclusion, this study provides two peptidomimetics as potential leads for treatment of staphylococcal infections under planktonic and sessile conditions.
N‐ and O‐Alkylation of 3‐Indolylcyclopropylacetic Acid Derivatives. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Multi-Site Photoplethysmographic and Electrocardiographic System for Arterial Stiffness and Cardiovascular Status Assessment (2019)

The development and validation of a system for multi-site photoplethysmography (PPG) and electrocardiography (ECG) is presented. The system could acquire signals from 8 PPG probes and 10 ECG leads. Each PPG probe was constituted of a light-emitting diode (LED) source at a wavelength of 940 nm and a silicon photomultiplier (SiPM) detector, located in a back-reflection recording configuration. In order to ensure proper optode-to-skin coupling, the probe was equipped with insufflating cuffs. The high number of PPG probes allowed us to simultaneously acquire signals from multiple body locations. The ECG provided a reference for single-pulse PPG evaluation and averaging, allowing the extraction of indices of cardiovascular status with a high signal-to-noise ratio. Firstly, the system was characterized on optical phantoms. Furthermore, in vivo validation was performed by estimating the brachial-ankle pulse wave velocity (baPWV), a metric associated with cardiovascular status. The validation was performed on healthy volunteers to assess the baPWV intra- and extra-operator repeatability and its association with age. Finally, the baPWV, evaluated via the developed instrumentation, was compared to that estimated with a commercial system used in clinical practice (Enverdis Vascular Explorer). The validation demonstrated the system's reliability and its effectiveness in assessing the cardiovascular status in arterial ageing.
Supplementary Figure 4 from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma (2023)

&lt;p&gt;PDF file, 77K, Analyses of SMS-KCNR cell xenografts.&lt;/p&gt;
Perturb-and-MAP Random Fields: Reducing Random Sampling to Optimization, with Applications in Computer Vision (2014)

This chapter contains sections titled: 7.1 Introduction, 7.2 Energy-BasedModeling: Standard Deterministic and Probabilistic Approaches, 7.3 Perturb-and-MAP for Gaussian and Sparse Continuous MRFs, 7.4 Perturb-and-MAP for MRFs with Discrete Labels, 7.5 Related Work and Recent Developments, 7.6 Discussion, Acknowledgments, 7.7 References
Delayed Choice Quantum Cryptography (2002)

Delayed-choice quantum cryptography is a novel protocol, incorporating an optical storage system, which achieves substantially higher effective data rates for quantum key distribution.
Highly Unusual Effects of π-Conjugation Extension on the Molecular Linear and Quadratic Nonlinear Optical Properties of Ruthenium(II) Ammine Complexes (2002)

We have used several techniques, including hyper-Rayleigh scattering and Stark spectroscopy, to investigate the effects of polyene chain length on the optical properties of complexes containing ruthenium(II) electron donor groups and pyridinium electron acceptors. In marked contrast with all other known donor-acceptor polyenes, conjugation extension beyond a single double bond in the dipolar complexes studied leads to blue-shifting of the intramolecular charge-transfer absorptions. Furthermore, the static first hyperpolarizabilities beta0 become maximized with trans-1,3-butadienyl linkages and then decrease in complexes with three CH=CH bonds. Our results clearly demonstrate that the molecular engineering criteria for metal-containing nonlinear optical chromophores can differ dramatically from those for purely organic compounds.
Lipophilic Statin Use and Risk of Breast Cancer Subtypes (2010)

These findings do not confirm previous reports of a possible preventive association.
Classification of proteins by sequence signatures (2004)

Abstract The prediction of a protein's function from its amino acid sequence is one of the most important tasks in bioinformatics. The traditional procedure of searching databases for related sequences and inferring the function from the best matches has several shortcomings and pitfalls. Alternatively, the sequence under study can be scrutinized for the occurrence of particular sequence signatures that can be associated with certain protein functionalities. Useful sequence signatures not only include short motifs such as protein modification sites or specific binding motifs but also encompass larger protein regions, such as homology domains. There exist a number of fundamentally different bioinformatical data structures, which can be used to store information about sequence signatures, thus making them available for the purpose of protein classification.
Microbial Genomics: Targeted Antimicrobial Therapy and Genome Vaccines (2014)

Abstract The first evidence that certain infectious diseases have a genetic predisposition initially came from a study showing an increased risk of mortality in children born to parents who also died from an infection. Since then, defects in genes encoding effectors of the immune response have been associated to an increased susceptibility to certain infections, like those caused by S. aureus and M. tuberculosis. High density DNA arrays capturing human genome wide variation can be used to analyze the association of certain single nucleotide polymorphisms (SNP) with susceptibility to different bacterial and viral diseases. Genome wide association studies have also identified a series of markers associated with the quality of individual responses to disease treatment. Large-scale profiling of the full RNA of peripheral blood mononuclear cells (PBMCs) by microarrays or deep RNA sequencing approaches has been applied to the identification of patterns of gene expression characteristic of certain human infections like tuberculosis, dengue, flu, S. aureus, salmonellosis etc. Data derived from these approaches will assist the diagnosis and prognosis of disease, the design of antiviral and antibiotic therapies, and the development of genetic tests to predict adverse reactions to antimicrobial drugs. In the vaccines field, novel tools of systems biology can be applied to the analysis of human immunological response patterns to vaccines in order to uncover molecular signatures of vaccine efficacy and guide the design and evaluation of new vaccines. This “systems vaccinology” strategy has been applied to examine the initial molecular signatures in individuals vaccinated against Yellow Fever or after administration of the trivalent inactivated influenza virus vaccine. Similar approaches have been used to study immune responses to Brucella melitensis and fungal infections. Integration of increasingly complex high throughput data into descriptive and predictive equations for immune responses to vaccines is expected to drive faster and more accurate ways of screening vaccine candidates for their effectiveness. Like in other genomic fields, the successful clinical application of these novel technologies will depend on the development of translational research approaches capable of dealing with the enormous amount and different types of generated information and with the uncertainty that is typical of common clinical scenarios.
Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population (2002)

Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is a prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae, has revealed natural factors that reduce the transmission of P. falciparum. Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated a large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations.
Structures of Four New Isoprenylated Xanthones, Cudraxanthones H,I,J, and K1,2 (1990)

Four new isoprenylated xanthones, cudraxanthone H,I,J, and K were isolated from the ethanol extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Moraceae), collected in China. The structures of cudraxanthones H,I,J, and K were shown to be 1- 4, respectively, on the basis of chemical and spectral evidence.
Abstract Derivation and Lie Algebras (1937)

If we set D\ =
UPWARD-SHIFT AND STEEPENING OF THE BLOOD PRESSURE RESPONSE TO EXERCISE IN HYPERTENSIVE SUBJECTS AT HIGH ALTITUDE (2018)

Objective: Acute exposure to high altitude hypobaric hypoxia induces a blood pressure rise in hypertensive humans, both at rest and during exercise. It is unclear whether this phenomenon reflects specific blood pressure hyperreactivity or rather an upward shift of blood pressure levels. We aimed at evaluating the extent and rate of blood pressure rise during exercise in hypertensive subjects acutely exposed to high altitude, and how these alterations can be counterbalanced by antihypertensive treatment. Design and method: Fifty-five mild hypertensive subjects, double-blindly randomized to placebo or to a fixed-dose combination of an angiotensin-receptor blocker (telmisartan 80 mg) and a calcium-channel blocker (nifedipine slow release 30 mg), performed a cardiopulmonary exercise test at sea level and after the first night of stay at 3260 m altitude. Results: High altitude exposure caused both a 8 mmHg upward-shift (p < 0.01) and a 0.4 mmHg/mL/Kg/min steepening (p < 0.05) of the systolic blood pressure/oxygen consumption relationship during exercise, independently of treatment (figure 1a). Telmisartan/nifedipine did not modify blood pressure reactivity to exercise, but downward shifted (p < 0.001) the relationship between systolic blood pressure and oxygen consumption by 26 mmHg, both at sea level and at altitude (figure 1a). Muscle oxygen delivery, as evaluated by means of the relationship between oxygen consumption and workload, was not influenced by altitude exposure, but was higher on telmisartan/nifedipine than on placebo (p < 0.01, figure 1b).Conclusions: In hypertensive subjects exposed to high altitude we observed a hypoxia-driven upward-shift and steepening of the blood pressure response to exercise. The effect of the combination of telmisartan/nifedipine slow-release outweighed these changes, and was associated with better muscle oxygen delivery.
Drawing on SketchPad: Reflections on Computer Science and HCI (2007)

This chapter contains section titled: Sutherland, 1963: “Sketchpad: A Man-Machine Graphical Communication System”
Quasilinear Elliptic Equations with Degenerations and Singularities (1997)

Presents modern methods and techniques for solving boundary value problems for nonlinear elliptic operators. Focus is upon existence and bifurcation results in appropriate Sobolev spaces. The subject of this book is the theory of nonlinear boundary value problems for elliptic operators with degeneration and singularity. It focuses on the existence and bifurcation of weak solutions in appropriate weighted Sobolev spaces. The main tools are functional analytic methods based on the variational approach and the theory of topological degree of monotone type nonlinear mapping. Topics covered include: existence results for higher order boundary value problems in a rather general setting. An extensive study of the p-Laplacian and its degenerated and singular modifications, mainly existence and bifurcation results on bounded domains as well as on the whole Euclidean space. The text requires some basic knowledge of nonlinear functional analysis and differential equations. Elementary facts on function spaces and the theory of nonlinear operators are discussed in the first chapter.
A Method for Growth Monitoring of Planted Quercus Forests by Photometry inside the Community (1998)

植物群落をモニタリングする手法の1つとして, 群落内の光環境に注目し, 群落内に入射する光の量を照度ではなく波長特性に応じて測定することによって, 群落の生育状況が把握できる可能性について考察を加えた. 葉の分光反射・分光透過率を分光放射計にて測定し, 樹葉の重なり合った時の光学モデルを作成したところLAの変化に対する感度は, 反射光よりも透過光が, 赤色光よりも近赤外光が高いということがわかった. 反射光の植生指数と同様に, 群落内透過植生指数 (R/IRとNDVI) の使用により群落の生育診断が可能である見通しを得た.
How Size and Performance of Hybrid Electric Vehicle Components are Influenced by Acceleration Patterns (1999)

&lt;div class="htmlview paragraph"&gt;The performance characteristics we expect of a car are determined by our experience with today's vehicles. This has led to a wide acceptance of acceleration patterns that require the power train and storage of an HEV (Hybrid Electric Vehicle) to operate under unfavorable load conditions. Since the power available from batteries not only depends on the State of Charge (SoC) but even more on the load history it is crucial to understand the relationship between acceleration power requirements and the different vehicle components involved. By means of simulation, it is shown that slight changes in the acceleration profile will have a tremendous impact on the size of the vehicle components and the fuel consumption.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The paper examines the power-distribution of the Federal Urban Drive Schedule and the optimization of the schedule to match the requirements of HEV's. The analysis is presented in the context of a gas turbine powered Hybrid Electric Vehicle which uses Advanced Lead Acid Batteries for energy storage&lt;/div&gt;
SU‐GG‐T‐458: Improved Accuracy and Potentially Faster CyberKnife Synchrony Treatments by Tightening Constraints (2008)

Purpose: To improve the accuracy and delivery time of CyberKnife Synchrony treatments. Method and Materials: The CyberKnife Synchrony system enables state of the art tumor tracking and targeting during stereotactic lung treatments. Unfortunately, for difficult cases some CyberKnife users have resorted to turning off all except one fiducial and loosening whatever constraints necessary to somehow complete every treatment. Is it possible to do better? We have discovered that ironically, judiciously tightening certain constraints can improve the correlation model and hence possibly decrease treatment time, while improving delivery accuracy. When tracking a single fiducial, the CyberKnife system has no way to realize when it has missed the fiducial and falsely locked to something else. This essentially can fill the correlation model with corrupted results that cause the algorithm to miss even worse on subsequent images. Alternatively, for these difficult cases if we still use multiple fiducials, loosen only the necessary parameters, while keeping the “Extraction Confidence Level” and “dxAB” threshold reasonably tight, the algorithm can determine when it has false locked. In this presentation we outline a simple procedure whereby the user can give the algorithm a “hint”, and hence salvage some of the potential misses to improve the correlation model rather than degrading it with corrupted estimates. Results: We present the values of parameters which enabled us to continue the treatments using at least three fiducials in selected case studies. Conclusion: The CyberKnife Synchrony system provides the tools to achieve unparalleled accuracy in delivering radiation to moving targets. However, the parameter set is so flexible and treatments are so intensely interactive, that attaining the full potential of the system is very dependent on the skill level and dedication of the staff.3
730 UPPER BODY POWER TESTING AS A PREDICTOR OF SUCCESS IN ELITE MALE BIATHLON SKIERS (1993)

Hilden, T. S.; Bacharach, D. W.; Rundoll, K.; Szmedra, L.; Taylor, M.; Wetzstein, C. J.; von Duvillard, S.; Street, G. Author Information
Surgical Management of Substernal Goiter (1994)

Seventeen cases of large substernal goiter are reviewed. The commonest clinical features were frequent upper respiratory tract infections, dyspnea and a cervical mass. Five of the patients had previous thyroidectomy. The substernal goiter was located in the right chest in 11 cases, the left chest in five and bilaterally in one case. On computed tomograms it was pretracheal or prevascular in ten cases and retrovascular in seven. Tracheal deviation was present in 15 cases, causing tracheal compression or stenosis in 14. Thyroidectomy was performed on all 17 patients (8 subtotal, 9 total) through a low transverse collar incision. The recommended technique for substernal goiter extending from the neck to a level below the subcarinal region includes concomitant finger dissection and upward traction of the cervical thyroid through the subcapsular plane, with obliteration of the postresection substernal dead space by sutures. Follow-up radiography showed that all the deviated tracheas had resumed near normal position 2-3 months postoperatively and the average diameter of the compressed tracheas had increased significantly.
Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking (2002)

Cigarette smokers inhale a broad range of carcinogens derived from tobacco and its pyrolysis products, including free radicals, which induce oxidative stress and subsequent lipid peroxidation (LPO). Miscoding carcinogen-DNA adducts are formed by cigarette smoke constituents and are thought to initiate lung carcinogenesis. The presence of various types of DNA damage was therefore analyzed in tumor adjacent uninvolved lung tissues of 13 smoking and 11 non-smoking operated lung cancer patients. O(4)-ethylthymidine (O(4)etT), 1,N(6)-ethenodeoxyadenosine ( epsilon dA) and 3,N(4)-ethenodeoxycytidine ( epsilon dC) were determined by immuno-enriched (32)P-postlabeling. Polycyclic aromatic hydrocarbon (PAH)-DNA adducts were measured as diagonal radioactive zones after nuclease P1 enriched (32)P-postlabeling. Mean O(4)etT and PAH-DNA adduct levels were higher in lung DNA of smokers than of non-smokers (O(4)etT/10(8) thymidine: 3.8 versus 1.6, P < 0.01; PAH-DNA adducts/10(8) nucleotides: 11.2 versus 2.2, P < 0.01). Pulmonary etheno-DNA adduct levels did not differ between smokers and non-smokers, but large inter-individual variations were observed (80- and 250-fold differences for epsilon dA and epsilon dC, respectively). As all smokers (except one) refrained from smoking at least for 1 week before surgery, our results demonstrate the persistence of O(4)etT and PAH-DNA adducts in human lung. A positive correlation obtained between O(4)etT and PAH-DNA adducts (R = 0.65, P < 0.01) suggests that both adducts are formed from cigarette smoke as the main exposure source. We conclude that in addition to the DNA adducts derived from PAH and tobacco-specific nitrosamines, miscoding O(4)etT lesions are formed by cigarette smoke that contribute to the increased genomic instability and increased lung cancer risk in smokers.
The Failure of 'The Failure of Poisson Modeling' for Internet Bandwidth Measurements (2005)

There is a classic paper, which claims that
many parameters of network traffic are best
modeled by stochastic distributions with
infinite variance.
We believe that although this paper is
correct, it has commonly been overinterpreted.
It is true that some distributions have infinite
variance, but not all. There are important cases
where distributions of traffic parameters have
finite variance.
As an example, we show that the end-to-end
available bandwidth must have finite variance,
outline a method for measuring it, and present
some experimental data.
Peldaños de una escalera (2000)

espanolAntonio Buero Vallejo fue un dramaturgo espanol, ganador de multiples premios como el Premio Lope de Vega de Teatro o el Premio Nacional de Teatro (tres veces). En este articulo se presentan aspectos de sus obras teatrales, de su biografia y de sus declaraciones. Todo esto se hace de manera alfabetica, sin que siga la verdadera linea temporal. En la ultima pagina se propone una actividad sobre Antonio Buero Vallejo y sus obras para el aula. EnglishAntonio Buero Vallejo was a Spanish playwright, winner of multiple awards such as the Premio Lope de Vega de Teatro or the Premio Nacional de Teatro (three times). This article presents aspects of his plays, his biography and his statements. All this is done alphabetically, without following the actual timeline. The last page proposes an activity about Antonio Buero Vallejo and his plays for teachers.
Nested polymerase chain reaction strategy simultaneously targeting DNA sequences of multiple bacterial species in inflammatory joint diseases. II. Examination of sacroiliac and knee joint biopsies of patients with spondyloarthropathies and other arthritides. (1997)

We found bacterial DNA in peripheral joints of patients with uOligo, while in patients with ReA, AS, and uSpA no bacterial DNA was detected in peripheral or SI joints. The failure to detect bacterial DNA in patients with SpA suggests autoimmune mechanisms operate in later stages of disease.