gebhart/patrepeval huggingface dataset:
Lonicera hypoglaucaInhibits Xanthine Oxidase and Reduces Serum Uric Acid in Mice (2009)

Xanthine oxidase (XOD) catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, and is a key enzyme in the pathogenesis of hyperuricemia. The ability of extracts of Lonicera hypoglauca (Caprifoliaceae) to inhibit XOD was investigated in this study. An ethanol extract (LH-crude) of the leaves of L. hypoglauca and its derived EtOAc soluble sub-fractions (LH-EA) significantly inhibited XOD activity, with IC50 values for LH-crude and LH-EA of 48.8 and 35.2 microg/mL. Moreover, LH-EA reduced serum urate levels IN VIVO in a potassium oxonate-induced hyperuricemic mouse model, by 70.1% and 93.7% of the hyperuricemic untreated group at doses of 300 and 500 mg/kg of LH-EA, respectively. Finally, we used bioactivity-guided fractionation to isolate a new bisflavonoid, loniceraflavone, which showed significant inhibition of XOD (IC50=0.85 microg/mL). These results suggest that L. hypoglauca and its extracts may have a considerable potential for development as an anti-hyperuricemia agent for clinical application.
Ferromagnetic dimer interactions in Cu2Cl4(CH3CN)2 (2003)

The magnetic properties of Cu2Cl4(CH3CN)2 are reported. Initially reported by Rundle and Willett [J. Chem. Phys. 40, 838, (1964)], the title compound consists of dimeric Cu(II) ions doubly bridged by two chloride ions. Each Cu(II) ion is further bonded to an additional nonbridging chloride ion and a nonbridging acetonitrile molecule. The dimers stack along the crystallographic a axis to form a ladder structure. Static magnetization measurements indicate the two Cu(II) ions within a dimer interact ferromagnetically with J/kB=40±2 K, while a weak ferromagnetic interaction, J′/kB=0.9±0.1 K, also exists between dimers. Ferromagnetic exchange is unusual for this structural motif and is attributed to the reduction of electronic density on the bridging ions due to the electron-accepting nature of the nitrile group in acetonitrile.
Recipes on hard thresholding methods (2011)

We present and analyze a new set of sparse recovery algorithms within the class of hard thresholding methods. We provide optimal strategies on how to set up these algorithms via basic “ingredients” for different configurations to achieve complexity vs. accuracy tradeoffs. Simulation results demonstrate notable performance improvements compared to state-of-the-art algorithms both in terms of data reconstruction and computational complexity.
Can graphene outperform indium tin oxide as transparent electrode in organic solar cells? (2015)

http://www.gianlucafiori.org/articles/paletti_2Dmaterials.pdf &#13;\n&#13;\nGraphene holds promises as a transparent electrode in flexible solar cells due to its high mobility and transparency. However, the experimental power conversion efficiency of cells with graphene electrode is still small (&lt;7%). In this paper, we evaluate possible engineering options to improve the power conversion efficiency, by means of multi-scale simulation approach including ab-initio simulations of graphene contacts to improve electrode workfunction and conductance, electromagnetic simulations to improve light management, and electrical simulations of complete cells. We find that the combined effect of using a transparent electrode of graphene with a few monolayers of MoO3 on top to optimize work function and resistivity, and of applying optimized grating to the graphene electrode, can increase power efficiency by up to 29%–47%, with respect to the ITO benchmark, depending on the material used for the hole transport layer (P3HT,PTB7, and Perovskite).
Editorial (2007)

Contents: W. Zima - K. Kolenberg - M. Briquet - M. Breger, Moment Method & Pixel-by-Pixel Method: Complementary Mode Identification I. Testing FG Vir-like pulsation modes; P. Van Cauteren - P. Lampens - A. Pigulski, Note on the short-period variability of V521 Cas in NGC 7789; K. D. Gazeas, P. G. Niarchos, K. A. Boutsia, SZ Lyn: New BVRI CCD observations and improved pulsational and orbital elements; A. Thoul - R. Scuflaire - M. Ausseloos - C. Aerts - A. Noels, Asteroseismology of the Beta Cephei star HD 129929. Effects of a change in the metal mixture; P. Lenz, Period04 - A successor to Period98 to be completed this year; J. Nendwich - U. Heiter - F. Kupka - N. Nesvacil - W. W. Weiss, Interpolation of Stellar Model Grids and Application to the NEMO Grid
3-D Scanning of Nonopaque Objects by Means of Imaging Emitted Structured Infrared Patterns (2010)

Three-dimensional surface acquisition is a subject that has been studied to a large extent; a significant number of techniques for acquiring shapes have been proposed, and a wide range of commercial solutions is available. Nevertheless, today's systems still have difficulties when digitizing objects that are transparent or semitransparent in the visible range. In this paper, some of the issues of traditional scanning systems are addressed by considering the radiative properties of materials. As a result, an infrared laser light-based scanner is presented for successfully acquiring the shape of complex surfaces by analyzing heat patterns that are emitted by the object.
A scalable divide-and-conquer parallel algorithm for finite state automata and its applications (1995)

Finite state automata (FSA) have been used to model dynamic systems found in many areas. They are also the building blocks of cellular automata. We present a new scalable divide-and-conquer alogrithm for the parallel simulation of FSAs that is fast and efficient, regardless of the relation between input size and the number of processors, and discuss its application to sequential circuit and queuing system analysis.
Comparison of Short-Term Effects of High-Intensity Interval Training vs Moderate Intensity Continuous Training on Anthropometric Characteristics of Overweight Young Women (2022)

Objectives: To conduct a comprehensive research work in order to find out the (time bound) efficient way to bring about changes in anthropometric measures with weight/fat reduction. Methods: In this study the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) were compared to see the reduction in body fat percentage in young university girls age between 20 to 25 years. Thirty subjects were recruited in HIIT (n=15) and MICT group (n=15) for 8 weeks. Pre and post fat percentage was assessed to see the changes before and after work out of two different exercise regimens. Results: Statistically significant improvement was found in both groups for weight (Mean difference = 3.04, P value = 0.00), However in the same manner other factors also showed significant improvement, BMI (Mean difference = 1.20, P value = 0.00), Waist circumference (Mean difference = 1.67, P value = 0.001), Hip circumference (Mean difference = 1.73, P value = 0.00) and body fat (Mean difference = 2.92, P value = 0.00). Therefore, all anthropometric measures showed differences but HIIT group showed maximum reduction in weight after regime (P value &lt; 0.00) Conclusion: Eight weeks of HIIT and MICT resulted in improvements in anthropometric measures along with changes in dietary habit intake. HIIT appears to be the predominant strategy for controlling weight because of its adherence and time efficiency. Keywords: Overweight Young women, Moderate intensity continuous training , Weight reduction, Abbreviations: High intensity interval training (HIIT), Moderate intensity continuous training (MICT), Maximum Heart Rate (MHR), Body Mass index (BMI), Body Fat (BF)
Momentum-Resolved Ultrafast Electron Dynamics in SuperconductingBi2Sr2CaCu2O8+δ (2011)

The nonequilibrium state of the high-T(c) superconductor Bi(2)Sr(2)CaCu(2)O(8+δ) and its ultrafast dynamics have been investigated by femtosecond time- and angle-resolved photoemission spectroscopy well below the critical temperature. We probe optically excited quasiparticles at different electron momenta along the Fermi surface and detect metastable quasiparticles near the antinode, since their decay toward the nodal region through e-e scattering is blocked by phase space restrictions. The observed lack of momentum dependence in the decay rates is in agreement with relaxation dynamics dominated by Cooper pair recombination in a boson bottleneck limit.
Comparison of Full Power and Partial Power Buck-Boost DC-DC Converters for Residential Battery Energy Storage Applications (2022)

In this paper, a Series Partial Power dc-dc Converter (S-PPC) is compared with Buck-Boost Full Power dc-dc Converter (BBFPC) as an interface between Battery Energy Storage System (BESS) and dc microgrid. To achieve a fair and accurate result, several Key Performance Indicators (KPI) are considered. non-active power processing, Component Stress Factor (CSF), and efficiency of both converters are compared at three points of battery charging (3 kW,2 kW, and 1 kW) and three points of battery discharging (3 kW, 2 kW, and 1 kW) application. Due to full power processing in BBFPC, higher non-active power processing, and CSF occurs in all operation points of the converters. Furthermore, the efficiency estimation results show that S-PPC has higher efficiency than BBFPC in all operation points, which was estimated using PSIM thermal module. Datasheet parameters of all the components are imported to the software library to simulate both converters. The simulation results confirm theoretical calculations and predictions.
Trans [OReV–OH] core stabilised by chelating N-heterocyclic dicarbene ligands (2012)

Three Re(v) N-heterocyclic carbene complexes [ReO(OH)(L(Me))(2)][PF(6)](1.4)[ReO(4)](0.6), [ReO(OH)(L(iPr))(2)][PF(6)](1.4)[ReO(4)](0.6) and [ReO(OH)(L(Bn))(2)][PF(6)](1.3)[ReO(4)](0.7) (L(Me) = 1,1'-methylene-bis(3-methylimidazole-2-ylidene); L(iPr) = 1,1'-methylene-bis(3-isopropylimidazole-2-ylidene) and L(Bn) = 1,1'-methylene-bis(3-benzylimidazole-2-ylidene)) with trans oxo and hydroxo at axial positions have been synthesized.
Supplementary Methods from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i> (2023)

Supplementary Methods from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;
An approach to turbulent flame theory (1970)

Is it possible to express the problem of calculating turbulent flame speeds as an eigenvalue problem that is analogous to the laminar flame speed problem? It is argued for grid turbulence that the answer is affirmative, and some benefits of pursuing such a calculation are exploited for the limiting case of a first-order reaction with vanishingly small heat release. The streamwise turbulent transport of reactant occupies a central role in the analysis. The equation governing the ensemble average of this quantity assumes different simplified forms in the limits of small-scale and large-scale turbulence. The criterion which is obtained for separating the small-scale and large-scale régimes differs from that of Damköhler and also from that of Kovasznay and Klimov. In the small-scale régime, turbulence produces a spatially varying diffusivity, the form of which can be ascertained only through an investigation of non-linear equations describing the statistical dynamics of production and decay of the velocity–concentration correlation. In the large-scale régime, which is of greater practical importance, the ensemble average of the streamwise turbulent reactant flux satisfies a linear ordinary differential equation whose solution for the growth and decay of the flux contains effects resembling wrinkling of the laminar flame, increasing of the effective diffusivity and augmentation of the effective reaction rate. An exact solution to the linear eigenvalue problem which arises in the large-scale limit reveals that turbulence enhances mean reactant consumption in the upstream portion of the flame and retards reactant consumption downstream. Formulas are given for the increase in flame speed and the increase in flame thickness that are produced by turbulence in the large-scale limit. Since the equations are relatively tractable in the large-scale limit, it is suggested that further study of these equations may yield improved descriptions of realistic turbulent flames.
Distributed fault-tolerant channel assignment in mobile networks with mobile base stations (1999)

Each cell has a fixed base station in traditional mobile networks. But, in a virtual cellular network (VCN), the fixed base stations are replaced by mobile base station. Thus, the mobile host-mobile base station communication link is wireless and the mobile base station-mobile base station communication link is also wireless. Due to the mobility of base stations, the co-channel interference range changes with time. As result, the channel reuse pattern is highly dynamic. Also, the link failure possibility is high. In previous works, although a cold cell turns into hot cell in a minute, a cold cell lends its own channels to current other hot cells. Thus, the lending cold cell becomes hot cell and borrows the request channels from other cold cells redundantly. We solve the problem of redundant borrowing using two thresholds and statistical analysis based on historic traffic information. Thus, our scheme supports fault-tolerant channel assignment in VCN.
Histone Deacetylase Inhibition Rescues Gene Knockout Levels Achieved with Integrase-Defective Lentiviral Vectors Encoding Zinc-Finger Nucleases (2013)

Zinc-finger nucleases (ZFNs) work as dimers to induce double-stranded DNA breaks (DSBs) at predefined chromosomal positions. In doing so, they constitute powerful triggers to edit and to interrogate the function of genomic sequences in higher eukaryotes. A preferred route to introduce ZFNs into somatic cells relies on their cotransduction with two integrase-defective lentiviral vectors (IDLVs) each encoding a monomer of a functional heterodimeric pair. The episomal nature of IDLVs diminishes the risk of genotoxicity and ensures the strict transient expression profile necessary to minimize deleterious effects associated with long-term ZFN activity. However, by deploying IDLVs and conventional lentiviral vectors encoding HPRT1- or eGFP-specific ZFNs, we report that DSB formation at target alleles is limited after IDLV-mediated ZFN transfer. This IDLV-specific underperformance stems, to a great extent, from the activity of chromatin-remodeling histone deacetylases (HDACs). Importantly, the prototypic and U.S. Food and Drug Administration-approved inhibitors of metal-dependent HDACs, trichostatin A and vorinostat, respectively, did not hinder illegitimate recombination-mediated repair of targeted chromosomal DSBs. This allowed rescuing IDLV-mediated site-directed mutagenesis to levels approaching those achieved by using their isogenic chromosomally integrating counterparts. Hence, HDAC inhibition constitutes an efficacious expedient to incorporate in genome-editing strategies based on transient IDLV-mediated ZFN expression. Finally, we compared two of the most commonly used readout systems to measure targeted gene knockout activities based on restriction and mismatch-sensitive endonucleases. These experiments indicate that these enzymatic assays display a similar performance.
3D Reconstruction of Anatomical Structures from Endoscopic Images (2012)

Copyright c ○ 2010 by Chenyu Wu. All rights reserved. This thesis is dedicated to my father who taught me to use what I have learned to help people, It is also dedicated to my mother who taught me that if I make a wish and work hard, it will come true. Finally this thesis is dedicated to my grandmothers who taught me Endoscopy is attracting increasing attention for its role in minimally invasive, computer-assisted and tele-surgery. Analyzing images from endoscopes to obtain meaningful information about anatomical structures such as their 3D shapes, deformations and appearances, is crucial to such surgical applications. However, 3D reconstruction of bones from endoscopic images is challenging due to the small field of view of the endoscope, large image distortion, featureless surfaces and occlusion by blood and particles. In this thesis, a novel methodology is developed for accurate 3D bone reconstruction from endoscopic images, by exploiting and enhancing computer vision techniques such as shape from shading, tracking and statistical modeling. We first designed a complete calibration scheme to estimate both geometric
Multivariate Analysis Reveals That Unsubstituted β-Ring and C8-Keto Structures Are Important Factors for Anti-Inflammatory Activity of Carotenoids (2021)

Carotenoids are natural lipophilic pigments with substantial health benefits. Numerous studies have demonstrated the anti-inflammatory activities of carotenoids, especially toward lipopolysaccharide-induced inflammatory responses. As such, there are few reports on the evaluation and comparison of the anti-inflammatory activities of carotenoids against inflammation induced by other stimuli. In this study, we used pathogen-associated molecular patterns, proinflammatory cytokines, degenerated proteins, and chemical irritants as inflammatory inducers to evaluate the anti-inflammatory activities of eight different carotenoids. Each carotenoid showed characteristic anti-inflammatory activities; thus, we conducted a multivariate analysis to clarify the differences among them. Unsubstituted β-ring (i.e., provitamin A) and C8-keto structures of carotenoids were found to be crucial for their inhibitory effects on the activation of nuclear factor-kappa B and interferon regulatory factors, respectively. Furthermore, we found that β-carotene and echinenone treatment increased intracellular retinoid levels in monocytes and that the retinoids showed the similar activities to β-carotene and echinenone. Taken together, the intake of both provitamin A and C8-keto carotenoids (e.g., siphonaxanthin and fucoxanthin) might be effective in improving the inflammatory status of individuals. A multivariate analysis of anti-inflammatory activities is a useful method for characterizing anti-inflammatory compounds.
Identification of Novel Serotonin Transporter Compounds by Virtual Screening (2014)

The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) plays an essential role in the termination of serotonergic neurotransmission by removing 5-HT from the synaptic cleft into the presynaptic neuron. It is also of pharmacological importance being targeted by antidepressants and psychostimulant drugs. Here, five commercial databases containing approximately 3.24 million drug-like compounds have been screened using a combination of two-dimensional (2D) fingerprint-based and three-dimensional (3D) pharmacophore-based screening and flexible docking into multiple conformations of the binding pocket detected in an outward-open SERT homology model. Following virtual screening (VS), selected compounds were evaluated using in vitro screening and full binding assays and an in silico hit-to-lead (H2L) screening was performed to obtain analogues of the identified compounds. Using this multistep VS/H2L approach, 74 active compounds, 46 of which had K(i) values of ≤1000 nM, belonging to 16 structural classes, have been identified, and multiple compounds share no structural resemblance with known SERT binders.
Selective M+-H+ coupled transport of cations through a liquid membrane by macrocyclic calixarene ligands (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective M+-H+ coupled transport of cations through a liquid membrane by macrocyclic calixarene ligandsReed M. Izatt, John D. Lamb, Richard T. Hawkins, Philip R. Brown, Steven R. Izatt, and James J. ChristensenCite this: J. Am. Chem. Soc. 1983, 105, 7, 1782–1785Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/ja00345a016https://doi.org/10.1021/ja00345a016research-articleACS PublicationsRequest reuse permissionsArticle Views529Altmetric-Citations186LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females (2018)

IgE sensitisation has increased significantly over the last decades and is a crucial factor in the development of allergic diseases. IgE antibodies are produced by B cells through the process of antigen presentation by dendritic cells, subsequent differentiation of CD4⁺ Th2 cells, and class switching in B cells. However, many of the factors regulating these processes remain unclear. These processes affect males and females differently, resulting in a significantly higher prevalence of IgE sensitisation in males compared to females from an early age. Before the onset of puberty, this increased prevalence of IgE sensitisation is also associated with a higher prevalence of clinical symptoms in males; however, after puberty, females experience a surge in the incidence of allergic symptoms. This is particularly apparent in allergic asthma, but also in other allergic diseases such as food and contact allergies. This has been partly attributed to the pro- versus anti-allergic effects of female versus male sex hormones; however, it remains unclear how the expression of sex hormones translates IgE sensitisation into clinical symptoms. In this review, we describe the recent epidemiological findings on IgE sensitisation in male and females and discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system at mucosal surfaces and how sex hormones may be involved in translating IgE sensitisation into clinical manifestations.
Molecular characterization of a carbapenem-hydrolyzing Î²-lactamase fromChryseobacterium(Flavobacterium)indologenes (1999)

Chryseobacterium (Flavobacterium) indologenes 001 clinical strain was resistant to several beta-lactam classes including carbapenems. Shotgun cloning experiments of Sau3AI restricted genomic DNA of C. indologenes 001 into pBKCMV cloning vector followed by transformation into Escherichia coli DH10B gave one recombinant plasmid possessing a 4.2-kb DNA insert. It encoded a pI 7.2 beta-lactamase of 239 amino acids (IND-1) which is a metallo-enzyme with a broad spectrum beta-lactam hydrolysis profile. This class B carbapenem-hydrolyzing beta-lactamase shares the highest identity (43%) with BlaB from C. meningosepticum, thus showing heterogeneity of carbapenem-hydrolyzing beta-lactamases in Chryseobacterium spp.
A Mean Line Prediction Method for Axial Flow Turbine Efficiency (1982)

A mean line loss system is described, capable of predicting the design point efficiencies of current axial turbines of gas turbine engines. This loss system is a development of the Ainley/Mathieson technique of 1951. The prediction method is tested against the “Smith’s chart” and against the known efficiencies of 33 turbines of recent design. It is shown to be able to predict the efficiencies of a wide range of axial turbines of conventional stage loadings to within ± 1 1/2 percent.