gebhart/patrepeval huggingface dataset:
Method for Measurement of Dietary Secoisolariciresinol Using HPLC with Multichannel Electrochemical Detection (1999)

We describe a sensitive and specific assay for the determination of the plant lignan secoisolariciresinol, one of the main dietary precursors to the mammalian derived lignans, enterodiol and enterolactone. Quantification of secoisolariciresinol aglycone is achieved by reversephase high-performance liquid chromatography with multichannel electrochemical detection after hydrolysis of the glycoside moieties. This approach affords greater specificity than conventional ultraviolet detection and has a detection limit of 2.8 pmol. The method is ideally suited to the determination of secoisolariciresinol in processed flaxseed samples and can be used to assess the level of incorporation of flaxseed in fortified foods.
Assessing the Comparative Effectiveness of Antidepressant Therapies (2001)

Although most patients received a physical treatment, they commonly judged psychotherapy and spontaneous improvement to be influential in their recovery. Reasons for such attributions are worthy of clarifying studies. Despite patients' concerns about the side effects and stigma of ECT as well as the side effects associated with the older antidepressants, these therapies were rated as more helpful by patients-and were more strongly associated with recovery-than the newer antidepressant drugs. Such overall results are compatible with an earlier study undertaken by us involving an independent sample and retrospective data. The overall gradient is clarified by studying depressive subtypes, allowing an important conclusion. Although the newer and older antidepressant drugs may be of similar effectiveness in nonmelancholic depression, the newer agents appear comparatively inferior for the treatment of melancholia, findings that have clinical implications and perhaps inform us about the pathogenesis of melancholia.
Microstructural Characterization of the Emulsified Cu<sub>47</sub>Ti<sub>33</sub>Zr<sub>11</sub>Ni<sub>6</sub>Sn<sub>2</sub>Si<sub>1</sub> Alloy Powder (2006)

Phase selection and microstructural morphology change of the Cu47Ti33Zr11Ni6Sn2Si1 alloy were investigated through the droplet emulsion technique(DET). The emulsified Cu47Ti33Zr11Ni6Sn2Sil alloy powders showed several different microstructures depending on the amount of undercooling. The amount of undercooling of the powders was monitored by differential thermal analysis and was matched with the microstructures. The phase transition of Cu47Ti33Zr11Ni6Sn2Sil alloy powders according to the increase of undercooling proceeds by the process Cu4Ti3 +CuTi +Cu2Ti +Cu51Zr14 → Cu4Ti3 + CuTi + Cu2Ti + Cu51Zr14 + CuTi2 → Cu2Ti + Cu51Zr14 + CuTi2 → Cu51Zr14 +CuTi2. Specifically, the morphology and scale of the CuTi2 phase were examined by SEM observation, and area fraction measurement using an image analyzer, transmission electron microscopy studies, and microhardness tests showed that the amorphous phase could be synthesized by DET. A microstructure selection map of Cu47Ti33Zr11Ni6Sn2Sil alloy powders for tailored solidification was also suggested.
InAs/AlSb double-barrier structure with large peak-to-valley current ratio: a candidate for high-frequency microwave devices (1990)

Negative differential resistance (NDR) in InAs/AlSb/InAs/AlSb/InAs double-barrier structures with peak-to-valley current (PVC) ratios as large as 11 at room temperature and 28 at 77 K is reported. This is a large improvement over previous results for these materials and is also considerably better than those obtained for the extensively studied GaAs/AlGaAs material system. The peak current density was also improved by reducing the barrier thickness, and values exceeding 10/sup 5/ A/cm/sup 2/ have been observed. These results suggest that InAs/AlSb structures are interesting alternatives to conventional GaAs/AlGaAs structures in high-frequency devices. NDR in a InAs/AlSb superlattice double-barrier structure with a lower PVC ratio than in the solid barrier case has also been observed. This result indicates that valley current contributions arising from X-point tunneling are negligible in these structures, consistent with the large band offset.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Transformations of meso‐Iminofunctionalized Pd(II) and Ni(II)‐Complexes of β‐Alkylsubstituted Porphyrins (2019)

The meso ‐imino derivatives of the palladium (II) and nickel (II) complexes of coproporphyrins I and II and β‐octaethylporphyrin were obtained by the Vilsmeier formylation followed by interaction with amines. The metal complexes of the azomethines obtained were transformed to the corresponding complexes of cyclopentane and cyclopentane‐pyrrolidone fused porphyrin derivatives by thermolysis. The plausible mechanism of such transformations was suggested and substantiated with quantum chemical calculations. Meso‐cyano‐, meso ‐hydroxy‐, and meso ‐aminocarbonyl derivatives of β‐octaethylporphyrin were obtained by treatment of the corresponding meso ‐imino derivatives with bases. Demetalation of the nickel complex of the meso ‐ hydroxy‐β‐octaethylporphyrin led to formation of the free base derivative. The structures of new types of the porphyrin derivatives were determined via X‐ray powder diffraction analysis. The obtained types of porphyrins are promising candidates to use as photosensitizers in medicine applications due to their longer wave absorption combined with high stability.
Assessing Leadership Readiness Using Developmental Personality Style: A tool for leadership coaching (2010)

This article presents a conceptual application for use in executive and leader development coaching engagements. The Leadership Readiness Index uses developmental personality style theory to establish categories of leadership readiness that can be used during the assessment phase of a coaching relationship. The article begins with an overview of leader development and is followed by a description of developmental personality style theory and its role in the construction of the Leadership Readiness Index. A brief discussion of potential uses for the index within the context of executive/leader coaching is provided. The article concludes with a discussion of the limitations of the index, future research strategies that can be applied to evaluate its viability and a summary of its potential contributions to evidence-based coaching practice.
Isolation and quantitation of immune complexes in diabetic syrian hamsters: a chronological study. (1983)

Immune complexes (IC) were isolated from the serum of streptozotocin (Sz)-induced diabetic hamsters by coprecipitation with an equine rheumatoid-C1q factor (RhC). The IC, comprised of an unknown antigen(s) and IgG, occurred at 2 distinct time intervals during the 12-week chronological study. Although all diabetic hamsters with hyperglycemia of 300 mg/dl had IC, there was no correlation between the occurrence or concentration of IC and the degree of hyperglycemia. The cycling nature of IC in the serum of diabetic hamsters suggests that the antigen component either fluctuates chronologically or that the IC contain different antigens that do not occur simultaneously.
SAW radio-frequency identification tag for the 6-GHz band (2015)

A SAW radio-frequency identification (RFID) tag has been investigated theoretically and experimentally in the 6-GHz frequency band. In the calculations, the finite thickness of the electrodes, the difference between the acoustic properties of thin-film and bulk aluminum, and the bulk scattering of the SAW energy by the electrodes are taken into account. The computed test RFID tag (with equidistant arrangement of signal reflectors) has been manufactured with the use of electron-beam lithography. It is shown that the measured and calculated RFID-tag time responses to the interrogating pulse are in good agreement and the code-pulse loss level is 50–55 dB.
Distribution of Monoclonal Antibodies in Intestinal and Urogenital Secretions of Mice Bearing Hybridoma ‘Backpack’ Tumours (1997)

Mice bearing IgA hybridoma 'backpack' tumours have been used to demonstrate that secretion of a single monoclonal IgA can protect against mucosal infection, but the relevance of this model to normal IgA protection is not clear. The authors analysed the distribution of specific monoclonal and total antibodies in bile, local intestinal secretions, cervical-vaginal secretions, urine and serum of mice bearing anti-cholera toxin (CT) IgA and IgG backpack tumours, with and without bile duct ligation. Backpack tumours resulted in high levels of both anti-CT and total IgA or IgG in serum, and IgA (but not IgG) in bile. Secretions recovered by absorbent filter 'wicks' from mucosal surfaces throughout the intestines of backpack tumour mice contained significant concentrations of monoclonal anti-CT IgA, but total IgA levels were as in normal mice. Neither monoclonal nor total IgA levels on mucosal surfaces were altered by bile duct ligation. Furthermore, anti-CT monoclonal IgA levels in local intestinal secretions of backpack tumour mice were comparable to specific polyclonal IgA levels previously elicited by mucosal immunization with CT. Thus, IgA-mediated protection against enteric challenge in the backpack tumour model may be a valid predictor of protection provided by natural mucosal immunization in vivo. High monoclonal IgA levels in bile, urine and the female genital tract, however, may not reflect the situation in normal immunized mice.
Helping dyslexic children attend to letters within visual word forms (2012)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
The breakup of a turbulent liquid jet in a gaseous atmosphere (1973)

An electrical method of detecting and measuring the breakup of liquid jets is applied to the turbulent case. New data produced by this means, together with previous data, support the conjecture that the theory and understanding that were developed in connexion with the breakup of laminar jets can be used as a guide for turbulent jets as well.
Interpretation of Positive Flow Cytometric Crossmatch in the Era of the Single-Antigen Bead Assay (2010)

Identification of HLA-DSA in D0 sera by the two sensitive techniques FCXM and SAB assay indicates which patients are at highest risk of subsequent acute allograft rejection and chronic allograft dysfunction.
Policy Improvement Directions for Reinforcement Learning in Reproducing Kernel Hilbert Spaces (2019)

The celebrated policy gradient algorithm solves the reinforcement learning problem by updating the control policy in the direction of the gradient of the value function. For the algorithm to converge it requires to be reset to the initial state after each policy update, or to perform exploring starts in which the system is reset to a random state. These restarts are possible in an offline setup where the policy is trained over multiple trajectories of the system. However, they prevent a fully online implementation in which the policy is optimized on the fly, that is, while the system is continuously following a single trajectory. In this work, we focus on the latter problem. We assume that the spaces of states and actions are continuous, and the policies are sought to be randomized versions of continuous functions belonging to a reproducing kernel Hilbert space. Under this framework, our main result is proving that gradients computed when the system is in a state down the trajectory serve as ascent directions for the value function defined with respect to the initial state. Building on that result we can prove convergence of the policy iterates to a ball of the critical points of the original value function. Numerical experiments in navigation problems support the theoretical conclusions.
Open Cirrus: A Global Cloud Computing Testbed (2010)

Open Cirrus is a cloud computing testbed that, unlike existing alternatives, federates distributed data centers. It aims to spur innovation in systems and applications research and catalyze development of an open source service stack for the cloud.
Enabling LAAS airport surface movement: mitigating the anomalous ionospheric threat (2010)

The Local Area Augmentation System (LAAS) can be used for both precision approach and Differentially Corrected Positioning Service (DCPS) applications. Through its support of DCPS, the LAAS Ground Facility (LGF) is required to meet the integrity requirements of all other operations that could use the LAAS VHF Data Broadcast (VDB). Our previous work demonstrated that the existing DCPS integrity requirements cannot be met by CAT I LAAS without changes to both the definition of DCPS integrity and the airborne receiver requirements. One of the implications is that some future applications of LAAS that planned to use DCPS, such as airport surface movement, cannot be supported by DCPS with the CAT I LAAS architecture. However, if airport surface movement is defined as a separate operation, it could be supported by the existing LGF geometry screening that mitigates the anomalous ionospheric threat for CAT I precision approach. The only change needed would be to increase σ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pr_air</sub> in airborne equipment to bound the higher multipath errors in the airport surface environment. Confirming this hypothesis requires a more-intensive study of the requirements of airport surface movement and is the subject of this paper. If LGF geometry screening itself cannot support airport surface movement, the results in this paper include additional aircraft geometry screening proposed in to lower the Maximum Acceptable Error (MAE) to a usable level while maintaining useful availability.
Case 3-1992 (1992)

Case Records of the Massachusetts General Hospital from The New England Journal of Medicine — Case 3-1992 — A 40-Year-Old Woman with Intermittent Hemoptysis and Mucosal Ulceration Found on Bronchoscopic Examination
Lepidoptera collecting in Kenya and Tanzania. (1993)

Situated in tropical Africa, on both sides of the Equator, Kenya and Tanzania possess an extraordinary rich Lepidoptera fauna (according to Larsen's latest book on Kenya: 871 species only for the Rhopalocera and Grypocera). The present paper reports on the author's participation in a non-entomological mini-expedition during January 1977 across those two countries, with comments on the areas where collecting was possible and practiced by him as a serious amateur lepidopterist. In addition there are photos of some interesting landscapes and, last but not least, a complete list of all the species captured and noted. En pleine Afrique equatoriale, a cheval sur 1'Equateur, le Kenya et la Tanzanie possedent une faune de Lepidopteres extraordinairement riche (871 especes seulement pour les Rhopaloceres et Hesperiides du Kenya, selon le tout recent ouvrage de Larsen). La presente note relate une mini-expedition non specifiquement entomologique en Janvier 1977 a travers ces deux pays, avec commmentaires de 1'auteur, lepidopteriste amateur eclaire, sur les lieux ou il a eu la possibilite de collectionner, recit agremente de quelques photos de biotopes interessants et surtout avec la liste complete des especes capturees et notees.
Comparison of current solutions for the provision of voice services to passengers on high speed trains (2002)

This paper examines the railway environment from the point of view of the provision of 2nd generation voice services. It examines the radio environment including fading, Doppler, transients, and penetration loss into carriages, as well as special situations such as cuttings and tunnels. The paper reports on the operation of the IS-95 and GSM voice services at high speeds, both assuming track side base stations and non-track side base stations. The paper draws conclusions on the different types of environment encountered both for conventional and high speed rail lines, and the effect these factors have on the overall link budget.
Therapeutic advances in gout (2007)

Proper gout management requires changes to the physician's attitude towards the disease; essentially: (1) an unequivocal diagnosis based in urate crystal identification, (2) a clearly settled aim of the treatment: crystal elimination from the joints and elsewhere, and (3) proper use of the available therapeutic alternatives. Promoting a proper lifestyle appears to be especially important.
Stem Cells & Regenerative Medicine (2010)

Advances in stem cell research in recent decades have been aided by progress in the development of novel technologies aimed at biological systems. At the same time mimicking stem cell niches in vitro has become crucial for both basic stem cell research and the development of innovative therapies based on stem cells. Innovative microscale technologies can contribute to our quantitative understanding of how phenomena at the microscale can determine stem cell behavior based on our increasing ability to control culture conditions and the throughput of data while reducing times and costs. In particular, microtechnologies must be designed and developed to capture the complexity of cell–substrate, cell–cell, and cell–soluble environment interactions considering the characteristic time and length scales of biological phenomena. While acknowledging the advantages of applying these technologies to stem cell culture, this chapter focuses on issues related to the control and mimicking of microenvironmental cues of the stem cell niche, such as substrate properties, cell topology, the soluble environment, and the electrophysiology.
13. Generation of a Conditional Gnaq Mutant Mouse Model of Capillary Malformation (2023)

PURPOSE: Capillary malformation (CM) is the most common type of vascular malformation. It is a sporadic, non-hereditary lesion caused by a somatic GNAQ-R183Q activating mutation in an endothelial cell (EC). Treatment for CM includes pulsed-dye laser and excision; drugs for CM do not exist. Our goal is to generate a mouse CM model in order to study the pathophysiology of CM and to develop drugs for patients. METHODS: A Gnaq-R183Q cDNA-IRES-GFP cassette was inserted into the mouse ROSA locus under control of the CAG promoter. To prevent expression from this allele a LoxP flanked gene trap (GT) was inserted downstream of the promotor. The GT was removed by Cre recombinase allowing expression of GNAQ-R183Q and GFP. By using a tamoxifen inducible Cre recombinase (CreERT2) specifically expressed in ECs (Cdh5CreERT2) we activated the ROSA-GT-Gnaq-R183Q allele in ECs at a chosen developmental time. RESULTS: Expression of GNAQ-R183Q in all ECs of a developing embryo using Cdh5Cre was embryonic lethal. ROSA-GT-GNAQ-R183Q+/-;Cdh5-Cre+/- (mutant) embryos had hemorrhaging blood vessels at embryonic day 14.5 (E14.5) and died at E15.5. ROSA-GT-GNAQ-R183Q+/-;Cdh5-CreERT2+/- (mutant) animals (n=3) were injected subcutaneously with tamoxifen after birth. Three months later animals developed intestinal vascular malformations. CONCLUSION: We successfully generated a conditional GNAQ mouse model of capillary malformation by activating mutant GNAQ-R183Q protein expression in ECs. Mutant animals developed a vascular malformation in the intestines. This murine model can be used to study the pathophysiology of capillary malformation as well as test drugs against the lesion.
CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells (2014)

Genome-wide association studies (GWAS) of 10 different cancers have identified pleiotropic cancer predisposition loci across a region of chromosome 5p15.33 that includes the TERT and CLPTM1L genes. Of these, susceptibility alleles for pancreatic cancer have mapped to the CLPTM1L gene, thus prompting an investigation of the function of CLPTM1L in the pancreas. Immunofluorescence analysis indicated that CLPTM1L localized to the endoplasmic reticulum where it is likely embedded in the membrane, in accord with multiple predicted transmembrane domains. Overexpression of CLPTM1L enhanced growth of pancreatic cancer cells in vitro (1.3-1.5-fold; PDAY7 < 0.003) and in vivo (3.46-fold; PDAY68 = 0.039), suggesting a role in tumor growth; this effect was abrogated by deletion of two hydrophilic domains. Affinity purification followed by mass spectrometry identified an interaction between CLPTM1L and non-muscle myosin II (NMM-II), a protein involved in maintaining cell shape, migration, and cytokinesis. The two proteins colocalized in the cytoplasm and, after treatment with a DNA-damaging agent, at the centrosomes. Overexpression of CLPTM1L and depletion of NMM-II induced aneuploidy, indicating that CLPTM1L may interfere with normal NMM-II function in regulating cytokinesis. Immunohistochemical analysis revealed enhanced staining of CLPTM1L in human pancreatic ductal adenocarcinoma (n = 378) as compared with normal pancreatic tissue samples (n = 17; P = 1.7 × 10(-4)). Our results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis, indicating that it should be considered as a plausible candidate gene that could explain the effect of pancreatic cancer susceptibility alleles on chr5p15.33.
A Comparison of Moments-Based Logo Recognition Methods (2014)

Logo recognition is an important issue in document image, advertisement, and intelligent transportation. Although there are many approaches to study logos in these fields, logo recognition is an essential subprocess. Among the methods of logo recognition, the descriptor is very vital. The results of moments as powerful descriptors were not discussed before in terms of logo recognition. So it is unclear which moments are more appropriate to recognize which kind of logos. In this paper we find out the relations between logos with different transforms and moments, which moments are fit for logos with different transforms. The open datasets are employed from the University of Maryland. The comparisons based on moments are carried out from the aspects of logos with noise, and rotation, scaling, rotation and scaling.
Wavelet analysis of air-jet injection stall control effects in an axi-centrifugal gas turbine engine (1997)

In this paper, Multi-Resolution Modal Analyses (MRMA) on experimental data are presented to assess the stall-suppressant potential of air injection for an axi-centrifug al turbo-jet engine. Compact Harmonic Wavelets (CHW) are used in MRMA to analyze the rotating and axial modes at compressor Stage 1 and 2. Air injection tests on the engine were done with eight, almost equally spaced injectors in front of the compressor Stage 1. In stall/surge and air-injection open-loop tests, static pressure oscillations are recorded with eight fastresponse sensors at each compressor stage. The MRMA algorithm, applied to the sensed static-pressure oscillations, is capable of detecting pre-stall instabilities in the rotating and axial modes at more than 400 rotor revolutions before stall/surge. It also yields accurate estimates for the open-loop frequency response of the modes under air-injection. The results reveal a high coherence in modal responses to jetvalves actuation, high transfer gains, and reliable position tracking of the rotating modes. The frequency response of mode amplitudes are also reliably predictable by the MRMA methods. Effective stall suppression with air injection is feasible with either a linear scheme on the modal spatial Fourier coefficients (SFC) or on their amplitude. The MRMA results also suggest that, to effectively suppress stall in this engine it is necessary to control not only the rotating modes, but also the axial mode.