gebhart/patrepeval huggingface dataset:
Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212 (2019)

<b>Background:</b> A deleterious, late-onset side effect of thoracic radiotherapy is the development of radiation-induced heart disease (RIHD). It covers a spectrum of cardiac pathology including also heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction. MicroRNA-212 (miR-212) is a crucial regulator of pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced heart failure. We aimed to investigate whether miR-212 and its selected hypertrophy-associated targets play a role in the development of RIHD. <b>Methods:</b> RIHD was induced by selective heart irradiation (50 Gy) in a clinically relevant rat model. One, three, and nineteen weeks after selective heart irradiation, transthoracic echocardiography was performed to monitor cardiac morphology and function. Cardiomyocyte hypertrophy and fibrosis were assessed by histology at week 19. qRT-PCR was performed to measure the gene expression changes of miR-212 and forkhead box O3 (FOXO3) in all follow-up time points. The cardiac transcript level of other selected hypertrophy-associated targets of miR-212 including extracellular signal-regulated kinase 2 (ERK2), myocyte enhancer factor 2a (MEF2a), AMP-activated protein kinase, (AMPK), heat shock protein 40 (HSP40), sirtuin 1, (SIRT1), calcineurin A-alpha and phosphatase and tensin homolog (PTEN) were also measured at week 19. Cardiac expression of FOXO3 and phospho-FOXO3 were investigated at the protein level by Western blot at week 19. <b>Results:</b> In RIHD, diastolic dysfunction was present at every time point. Septal hypertrophy developed at week 3 and a marked LVH with interstitial fibrosis developed at week 19 in the irradiated hearts. In RIHD, cardiac miR-212 was overexpressed at week 3 and 19, and FOXO3 was repressed at the mRNA level only at week 19. In contrast, the total FOXO3 protein level failed to decrease in response to heart irradiation at week 19. Other selected hypertrophy-associated target genes failed to change at the mRNA level in RIHD at week 19. <b>Conclusions:</b> LVH in RIHD was associated with cardiac overexpression of miR-212. However, miR-212 seems to play a role in the development of LVH via FOXO3-independent mechanisms in RIHD. As a central regulator of pathologic remodeling, miR-212 might become a novel target for RIHD-induced LVH and heart failure.
Inferring and predicting context of mobile users (2007)

User context characterizes the user's environment and situation. Knowledge of user context helps to improve how people communicate and enables new context-aware applications. This letter concerns inferring and predicting mobile users' context from time-stamped sequences of location identifiers. Results are validated using data from operational Global System for Mobile Communications <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∗</sup> (GSM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∗</sup> ) networks. © 2007 Alcatel-Lucent.
Effects of a wastewater treatment plant effluent on the marine bivalve Mytilus galloprovincialis through a metabolomics approach (2018)

International audience
Three-dimensional ultrahigh-resolution optical coherence tomography imaging of lung tissues (2013)

We have been investigating ultrahigh resolution optical coherence tomography (UHR-OCT) imaging of lung tissues using fiber based super continuum (SC) sources. The high power, low-noise, Gaussian shaped SC generated with ultrashort pulses and optical fibers at several wavelength regions were used as the broadband light sources for UHROCT. Since the lung consists of tiny alveoli which are separeted by thin wall, the UHR-OCT is supposed to be effective for lung imaging. The normal and diseased lung tissues were observed without invasive procedures to the lung itself. The clear images of alveoli were observed with index matching effect by saline. In this work, we investigated the three-dimensional UHR-OCT imaging of lung structure. The lungs of rats inflated with 10% formalin at 5 cmH<sub>2</sub>O, 15 cmH<sub>2</sub>O, and 20 cmH<sub>2</sub>O pressure were prepared as the sample for investigation of size and shape of the lung structure. These samples were fixed with 10% formalin. The interalveolar septa, thin walls separating the alveoli, were clearly observed. The difference of size and shape of alveoli and thier three-dimensional network was clearly observed from the UHR-OCT images. The clear images of alveoli were observed with index matching effect of 10% formalin. We investigated the wavelength dependence of 3D UHR-OCT image of lung structure at 800 nm, 1060 nm, and 1700 nm wavelength regions. The 3D UHR-OCT images of structure of rat lung were clearly observed in all wavelength regions and wavelength dependence of imaging was discussed.
Reinforcement Learning-Based Genetic Algorithm in Optimizing Multidimensional Data Discretization Scheme (2020)

Feature discretization can reduce the complexity of data and improve the efficiency of data mining and machine learning. However, in the process of multidimensional data discretization, limited by the complex correlation among features and the performance bottleneck of traditional discretization criteria, the schemes obtained by most algorithms are not optimal in specific application scenarios and can even fail to meet the accuracy requirements of the system. Although some swarm intelligence algorithms can achieve better results, it is difficult to formulate appropriate strategies without prior knowledge, which will make the search in multidimensional space inefficient, consume many computing resources, and easily fall into local optima. To solve these problems, this paper proposes a genetic algorithm based on reinforcement learning to optimize the discretization scheme of multidimensional data. We use rough sets to construct the individual fitness function, and we design the control function to dynamically adjust population diversity. In addition, we introduce a reinforcement learning mechanism to crossover and mutation to determine the crossover fragments and mutation points of the discretization scheme to be optimized. We conduct simulation experiments on Landsat 8 and Gaofen-2 images, and we compare our method to the traditional genetic algorithm and state-of-the-art discretization methods. Experimental results show that the proposed optimization method can further reduce the number of intervals and simplify the multidimensional dataset without decreasing the data consistency and classification accuracy of discretization.
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births (2018)

Abstract Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood. Histopathological studies of preterm birth suggest advanced villous maturity may have a role in idiopathic spontaneous preterm birth (isPTB). To better understand pathological and molecular basis of isPTB, we compared placental villous transcriptomes from carefully phenotyped cohorts of PTB due to infection or isPTB between 28-36 weeks gestation and healthy term placentasu. Transcriptomic analyses revealed a unique expression signature for isPTB distinct from the age-matched controls that were delivered prematurely due to infection. This signature included the upregulation of three IGF binding proteins ( IGFBP1, IGFBP2, and IGFBP6 ), supporting a role for aberrant IGF signaling in isPTB. However, within the isPTB expression signature, we detected secondary signature of inflammatory markers including TNC , C3 , CFH, and C1R , which have been associated with placental maturity. In contrast, the expression signature of the gestational age-matched infected samples included upregulation of proliferative genes along with cell cycling and mitosis pathways. Together, these data suggest an isPTB molecular signature of placental hypermaturity, likely contributing to the premature activation of inflammatory pathways associated with birth and providing a molecular basis for idiopathic spontaneous birth.
Cloning and characterization of ribosomal RNA genes from wheat and barley (1979)

Wheat and barley DNA enriched for ribosomal RNA genes was isolated from actinomycin D-CsCl gradients and used to clone the ribosomal repeating units in the plasmid pAC184. All five chimeric plasmids isolated which contained wheat rDNA and eleven of the thirteen which had barley rDNA were stable and included full length ribosomal repeating units. Physical maps of all length variants cloned have been constructed using the restriction endonucleases Eco Rl, Bam Hl, Bgl II, Hind III and Sal I. Length variation in the repeat units was attributed to differences in the spacer regions. Comparison of Hae III and Hpa II digestion of cereal rDNAs and the cloned repeats suggests that most methylated cytosines in natural rDNA are in -CpG-. Incomplete methylation occurs at specific Bam Hl sites in barley DNA. Detectable quantities of ribosomal spacer sequences are not present at any genomic locations other than those of the ribosomal RNA gene repeats.
Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 (2021)

In this single-center cohort study of patients with COVID-19, lower testosterone concentrations during hospitalization were associated with increased disease severity and inflammation in men. Hormone signaling pathways in monocytes did not parallel serum hormone concentrations, and further investigation is required to understand their pathophysiologic association with COVID-19.
Ecology and Evolution of Plant Microbiomes (2019)

Microorganisms colonizing plant surfaces and internal tissues provide a number of life-support functions for their host. Despite increasing recognition of the vast functional capabilities of the plant microbiome, our understanding of the ecology and evolution of the taxonomically hyperdiverse microbial communities is limited. Here, we review current knowledge of plant genotypic and phenotypic traits as well as allogenic and autogenic factors that shape microbiome composition and functions. We give specific emphasis to the impact of plant domestication on microbiome assembly and how insights into microbiomes of wild plant relatives and native habitats can contribute to reinstate or enrich for microorganisms with beneficial effects on plant growth, development, and health. Finally, we introduce new concepts and perspectives in plant microbiome research, in particular how community ecology theory can provide a mechanistic framework to unravel the interplay of distinct ecological processes-i.e., selection, dispersal, drift, diversification-that structure the plant microbiome.
New Amebacides. II. The Preparation of Some N-Alkyl-N-benzylhaloacetamides (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Amebacides. II. The Preparation of Some N-Alkyl-N-benzylhaloacetamidesAlexander R. Surrey and Marcia K. RukwidCite this: J. Am. Chem. Soc. 1955, 77, 14, 3798–3801Publication Date (Print):July 1, 1955Publication History Published online1 May 2002Published inissue 1 July 1955https://pubs.acs.org/doi/10.1021/ja01619a035https://doi.org/10.1021/ja01619a035research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fehldiagnose einer Lebermetastase als benigner Tumor in der kontrastmittelgestützten „Low-MI-Real-Time”-Sonographie mit SonoVue (2005)

Die kontrastmittelverstärkte Sonographie im phaseninvertierten kontrastharmonischen Modus stellt eine viel versprechende neue Technik zur Detektion und Charakterisierung von Leberherden dar. So wird berichtet, dass sich maligne von benignen Lebertumoren mit einer fast 100 %igen Sensitivität differenzieren lassen bzw. eine Artdiagnose mit einer Genauigkeit von über 90 % möglich sei (Hohmann et al. Fortschr Röntgenstr 2003; 175: 835 - 843).
Physics-Based Device-Level Power Electronic Circuit Hardware Emulation on FPGA (2014)

Accurate models of power electronic devices are necessary for hardware-in-the-loop (HIL) simulators. This paper proposes a digital hardware emulation of device-level models for the insulated gate bipolar transistor (IGBT) and the power diode on the field programmable gate array (FPGA). The hardware emulation utilizes detailed physics-based nonlinear models for these devices, and features a fully paralleled implementation using an accurate floating-point data representation in VHSIC hardware description language (VHDL) language. A dc-dc buck converter circuit is emulated to validate the hardware IGBT and diode models, and the nonlinear circuit simulation process. The captured oscilloscope results demonstrate high accuracy of the emulator in comparison to the offline simulation of the original system using Saber software.
Supplementary Figure S4 from Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells (2023)

&lt;p&gt;tBreg-induced MDSC express multiple surface and intra-cellular markers.&lt;/p&gt;
Makrofág adenozin receptorok szepszisben = Macrophage adenosine receptors in sepsis (2011)

Csoportunk korábbi kísérletek során kimutatta, hogy az adenozin növeli a hőinaktivált Escherichia coli kezelés által indukált IL-10 termelést egér makrofág sejtekben és a Raw 264.7 egér makrofág sejtvonalban is. Munkánk során arra kerestük a választ, hogy mely toll-szerű receptorok (TLR) játszanak szerepet a folyamatban. Kísérleteink során egérből származó intraperitoneális (IP) makrofágokat illetve Raw 264.7 egér makrofág sejtvonalat kezeltünk különböző TLR agonistákkal adenozin jelenlétében illetve hiányában. Eredményeink alapján az IP makrofágoknál a HKLM illetve az LPS, míg a Raw 264.7 sejteknél a PAM3CSK4, az LPS, illetve az ODN1826 kezelés esetében detektáltuk a legnagyobb mennyiségű IL-10 felszabadulást adenozin jelenlétében. Ezek az adatok a TLR2, a TLR4, a TLR1/2, a TLR9 szerepét valószínűsítik. A továbbiakban az adenozin receptor stimulációnak T sejtek aktiváció által indukált sejthalálában (AICD) játszott szerepét vizsgáltuk. Eredményeink szerint az A2A receptor agonista CGS216820-val végzett kezelések csökkentették az AICD során kulcs szerepet játszó Fas receptor illetve liganduma (FasL) kifejeződését, illetve a caspase-3 és PARP apoptotikus fehérjék hasítását. |
Millimeter Wave Channel Modeling and Cellular Capacity Evaluation (2014)

With the severe spectrum shortage in conventional cellular bands, millimeter wave (mmW) frequencies between 30 and 300 GHz have been attracting growing attention as a possible candidate for next-generation micro- and picocellular wireless networks. The mmW bands offer orders of magnitude greater spectrum than current cellular allocations and enable very high-dimensional antenna arrays for further gains via beamforming and spatial multiplexing. This paper uses recent real-world measurements at 28 and 73 GHz in New York, NY, USA, to derive detailed spatial statistical models of the channels and uses these models to provide a realistic assessment of mmW micro- and picocellular networks in a dense urban deployment. Statistical models are derived for key channel parameters, including the path loss, number of spatial clusters, angular dispersion, and outage. It is found that, even in highly non-line-of-sight environments, strong signals can be detected 100-200 m from potential cell sites, potentially with multiple clusters to support spatial multiplexing. Moreover, a system simulation based on the models predicts that mmW systems can offer an order of magnitude increase in capacity over current state-of-the-art 4G cellular networks with no increase in cell density from current urban deployments.
Photodecarboxylation of Xanthone Acetic Acids:  C−C Bond Heterolysis from the Singlet Excited State (2006)

[reaction: see text] Irradiation of 2- and 4-xanthone acetic acid in aqueous buffer (pH 7.4) leads to efficient (Phi = 0.67 and 0.64, respectively) photodecarboxylation to give the corresponding methyl products, consistent with an intermediate benzylic carbanion. Fluorescence and laser flash photolysis (LFP) studies suggest singlet state reactivity, which is unusual for aromatic ketones. 3-Xanthone acetic acid is photoinert under the same conditions. The results suggest that the reactive xanthone acetic acids are promising precursors for carbanion-mediated photocages.
Synthesis of Atropisomeric Heterotopic S-Donor Ligands through Asymmetrization of C2-Symmetry 2,2’-Disubstituted 1,1’-Binaphthalene Derivatives (2000)

Useful synthetic procedures for the conversion of C2 symmetry 1,1’-binaphthalene-2,2’-dithiol (BINAS) and 1,1’-binaphthalene-2,2’-diol (BINOL) into heterotopic S,S’- and heterodonor O,S-chelating atropisomeric ligands have been devised. Monoalkylation of the dithiol is successfully accomplished by asymmetrization of the corresponding dicarbamate through selective removal of one S-carbamoyl group, while asymmetrization of the diol can be more readily achieved by selective monoacylation.
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase (2006)

Separase is an evolutionarily conserved protease that is essential for chromosome segregation and cleaves cohesin Scc1/Rad21, which joins the sister chromatids together. Although mammalian separase also functions in chromosome segregation, our understanding of this process in mammals is still incomplete. We generated separase knockout mice, reporting an essential function for mammalian separase. Separase-deficient mouse embryonic fibroblasts exhibited severely restrained increases in cell number, polyploid chromosomes, and amplified centrosomes. Chromosome spreads demonstrated that multiple chromosomes connected to a centromeric region. Live observation demonstrated that the chromosomes of separase-deficient cells condensed, but failed to segregate, although subsequent cytokinesis and chromosome decondensation proceeded normally. These results establish that mammalian separase is essential for the separation of centromeres, but not of the arm regions of chromosomes. Other cell cycle events, such as mitotic exit, DNA replication, and centrosome duplication appear to occur normally. We also demonstrated that heterozygous separase-deficient cells exhibited severely restrained increases in cell number with apparently normal mitosis in the absence of securin, which is an inhibitory partner of separase.
Simultaneously constraining SPECT activity estimates with primary and secondary energy window projection data (2003)

Single photon emission computed tomography (SPECT) projection data acquired in primary (photopeak) and secondary energy windows provide independent constants on the source activity distribution. A novel image reconstruction method is developed which uses these constraints simultaneously and solves a single matrix equation to estimate the source activity. This simultaneous constraint reconstruction method (I) is evaluated in a Monte Carlo experiment and compared with activity estimation using only primary window projection data with (III) and without (II) modeling the detection of scattered photons in the system matrix, and with estimation using dual energy window scatter subtraction (IV). The detection of photons emitted by Tc-99m within a water-filled cylinder is simulated at different count levels. The energy windows are 91-125 and 126-154 keV, and the images are reconstructed using noise-dependent generalized matrix inverses. Activity estimation using the simultaneous constraint method (I) yields no appreciable improvement in quantitative accuracy or resolution over method III. Methods I and III, which require Monte Carlo modeling of photon scatter, are only slightly superior to activity estimation using dual energy window scatter subtraction (IV).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A simulation study of a hierarchical, rule-based method for system-level fault detection and diagnostics in HVAC systems (2005)

A system-level fault detection and diagnostic (FDD) method for heating, ventilation, and air conditioning (HVAC) systems was developed. It functions as an interface between multiple, equipment-specific FDD tools and a human operator. The method resolves conflicting fault reports from equipment-specific FDD tools, performs FDD at the system level, and presents an integrated view of an HVAC system's fault status to an operator. A simulation study to test and evaluate the method was conducted.
Formation of shallow acceptor states in the surface region of thin film diamond (2001)

Considerable interest exists in fabrication of electronic devices from thin film polycrystalline diamond. To date, doping this material to achieve good free carrier concentrations and mobilities at room temperature has proved difficult. In this letter we report low temperature Hall effect measurements made on diamond films subjected to a hydrogenation process, such that the near surface region becomes p type without the addition of conventional dopant atoms. High carrier concentrations and mobilities can be achieved. The change in carrier concentration within the temperature range 10–300 K does not change as expected for most films, actually increasing as the temperature falls. This effect could be related to the confinement of carriers at the surface caused by the dipole provoked by adsorbed hydrogen on the diamond. However, polished films display more conventional behavior in that the carrier concentration falls with falling temperature.