gebhart/patrepeval huggingface dataset:
Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines (2010)

We previously demonstrated that baseline synovial overexpression of the interleukin-7 receptor α-chain (IL-7R) is associated with poor response to tumour necrosis factor (TNF) blockade in rheumatoid arthritis (RA). We found that IL-7R gene expression is induced in fibroblast-like synovial cells (FLS) by the addition of TNF-α, IL-1β and combinations of TNF-α+ IL-1β or TNF-α+ IL-17, thereby suggesting that these cytokines play a role in the resistance to TNF blockade in RA. Because FLS and CD4 T cells also produce a soluble form of IL-7R (sIL-7R), resulting from an alternative splicing of the full-length transcript, we wondered whether expression of sIL-7R is similarly regulated by pro-inflammatory cytokines. We also investigated whether sIL-7R is detectable in the serum of RA patients and associated with response to TNF blockade. RA FLS were cultured in the presence of pro-inflammatory cytokines and sIL-7R concentrations were measured in culture supernatants. Similarly, sIL-7R titres were measured in sera obtained from healthy individuals, early untreated RA patients with active disease and disease-modifying anti-rheumatic drug (DMARD)-resistant RA patients prior to initiation of TNF-blockade. Baseline serum sIL-7R titres were correlated with validated clinical measurements of disease activity. We found that exposure of RA FLS to pro-inflammatory cytokines (TNF-α, IL-1β and combinations of TNF-α and IL-1β or TNF-α and IL-17) induces sIL-7R secretion. Activated CD4 T cells also produce sIL-7R. sIL-7R serum levels are higher in RA patients as compared to controls. In DMARD-resistant patients, high sIL-7R serum concentrations are strongly associated with poor response to TNF-blockade. In conclusion, sIL-7R is induced by pro-inflammatory cytokines in RA FLS. sIL-7R could qualify as a new biomarker of response to therapy in RA.
Sensitive and specific detection of sporadic Creutzfeldt–Jakob disease brain prion protein using real-time quaking-induced conversion (2011)

Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can be monitored in real time using the dye thioflavin T. It therefore has potential advantages over analogous cell-free PrP conversion assays such as protein misfolding cyclic amplification (PMCA). The QuIC assay and the related amyloid seeding assay have been developed largely using rodent-passaged sheep scrapie strains. Given the potential RT-QuIC has for Creutzfeldt-Jakob disease (CJD) research and human prion test development, this study characterized the behaviour of a range of CJD brain specimens with hamster and human recPrP in the RT-QuIC assay. The results showed that RT-QuIC is a rapid, sensitive and specific test for the form of abnormal PrP found in the most commonly occurring forms of sporadic CJD. The assay appeared to be largely independent of species-related sequence differences between human and hamster recPrP and of the methionine/valine polymorphism at codon 129 of the human PrP gene. However, with the same conditions and substrate, the assay was less efficient in detecting the abnormal PrP that characterizes variant CJD brain. Comparison of these QuIC results with those previously obtained using PMCA suggested that these two seemingly similar assays differ in important respects.
Histidine decarboxylase expression in pancreatic endocrine cells and related tumors (2004)

Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors. Recent findings have demonstrated a high percentage of HDC immunoreactivity in many neuroendocrine tumors, including carcinoid tumors, small cell carcinomas of the lung, pheochromocytomas, and medullary carcinomas of the thyroid. HDC immunostaining was applied to pancreatic islet cells and related tumors to explore possible expression of HDC as a wide spectrum marker for neuroendocrine differentiation. A total of 24 cases (22 pancreatic endocrine neoplasms, one small cell carcinoma of the pancreas, and one mixed exocrine-endocrine carcinoma) along with normal pancreatic tissue were immunostained with the anti-HDC antibody. In a normal pancreas, a double immunostaining revealed possible colocalization of HDC with glucagon- or insulin-positive cells in the islets. Seventeen of 22 pancreatic endocrine neoplasms (77%) were found to be positive for HDC, and no distinct relation to hormonal activity was observed. One small cell carcinoma was strongly positive to HDC. One non-functional tumor with mixed exocrine and endocrine components showed a diffuse positive immunostaining for HDC, and some neoplastic glucagon- or somatostatin (SRIF)-positive cells coexpressed HDC. In conclusion, we demonstrated that the majority of pancreatic endocrine tumors expressed HDC, and we suggest that HDC is a wider new marker for neuroendocrine differentiation.
INEX-MED: a Knowledge Graph to explore and link heterogeneous bio-medical data (2019)

International audience
A kinetic study of reactions of tocopherols with a substituted phenoxyl radical (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic study of reactions of tocopherols with a substituted phenoxyl radicalKazuo Mukai, Kazuyuki Fukuda, Kunihiko Tajima, and Kazuhiko IshizuCite this: J. Org. Chem. 1988, 53, 2, 430–432Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/jo00237a040https://doi.org/10.1021/jo00237a040research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Challenges in the Early Diagnosis and Staging of Fallopian-Tube Carcinomas Associated with BRCA Mutations (2003)

The histopathologic diagnosis of fallopian-tube carcinoma has been traditionally made at an advanced stage. More recently, predictive genetic BRCA testing is leading to the recognition in prophylactic oophorectomy specimens of clinically occult tubal carcinomas that are frequently in situ or small early-stage invasive carcinomas. These early lesions present a challenge in diagnosis and staging because the available criteria for the histopathologic diagnosis and staging of tubal carcinoma were derived from the clinicopathologic experience derived from the usual high-stage tubal carcinomas. The detection of early-stage tubal carcinomas requires that all tubal tissue be submitted for histologic examination. The diagnostic criteria for tubal in situ carcinoma have been defined, although the natural history of this lesion is unclear. Similarly defined criteria for a diagnosis of tubal dysplasia are lacking. Any early, invasive tubal carcinoma should be staged using a refined staging system suitable for early stage and fimbrial carcinomas. The adoption of these methods should increase our knowledge of early-stage tubal carcinoma and may add to our understanding of the development of ovarian-epithelial neoplasia.
Electrophoretic Component of Electric Pulses Determines the Efficacy of In Vivo DNA Electrotransfer (2005)

Efficient DNA electrotransfer can be achieved with combinations of short high-voltage (HV) and long low voltage (LV) pulses that cover two effects of the pulses, namely, target cell electropermeabilization and DNA electrophoresis within the tissue. Because HV and LV can be delivered with a lag up to 3000 sec between them, we considered that it was possible to analyze separately the respective importance of the two types of effects of the electric fields on DNA electrotransfer efficiency. The tibialis cranialis muscles of C57BL/6 mice were injected with plasmid DNA encoding luciferase or green fluorescent protein and then exposed to various combinations of HV and LV pulses. DNA electrotransfer efficacy was determined by measuring luciferase activity in the treated muscles. We found that for effective DNA electrotransfer into skeletal muscles the HV pulse is prerequisite; however, its number and duration do not significantly affect electrotransfer efficacy. DNA electrotransfer efficacy is dependent mainly on the parameters of the LV pulse(s). We report that different LV number, LV individual duration, and LV strength can be used, provided the total duration and field strength result in convenient electrophoretic transport of DNA toward and/or across a permeabilized membrane.
Abstract 17523: Incidence of Atrial Fibrillation and Relation with Cardiovascular Events, Heart Failure and Mortality in a European Community-Based Study - Data of PREVEND (2014)

Objectives: We investigate the incidence of atrial fibrillation (AF), risk factors of incident AF, and associations with cardiovascular events, systolic and diastolic heart failure and all cause mo...
Ontogeny of primary lymphoid organs and lymphoid stem cells (1984)

Cells of the immune system go through a series of important developmental steps that begin early in embryonic life and include, first, the various waves of hemopoietic-cell production in the embryo and, second, the homing of these cells to the hemopoietic organs, which are the sites of hemopoiesis and lymphopoiesis in embryonic and adult life. The avian embryo is an important model for investigating these early steps; and this paper presents a comprehensive review of the work done on the early ontogeny of the avian immune system.
DESIGN OF RADIX-8 MODIFIED BOOTH ENCODED BASED MODULO 2n+1 MULTIPLIER USING HARD MULTIPLE GENERATOR (2017)

The method 2n + 1 multiplier is the congestion of a wide drift of applications from silt collection structure arithmetic to cryptanalysis.Recently, with the request for low-power and energy-efficient designs, the radix-8 Booth recoding archaic considered to evolve modulo 2n + 1 multipliers.This temporary presents two different manners to raise the performance and improve the competence of radix-8 modulo 2n + 1 multipliers.The first skill is a manner to far cut down on the part of bias terms that need afterlife organized.The assist routine is a new hard numerous alternator stationed on a parallel-prefix network that computer only for odd positions; it gravitates a lightweight parallel prefix adder for the computing of a third of a portion with significant area-saving and upgraded fan-out.The implementation results positioned on the TSMC 65-nm robotics show improvements of not fully 27% and meantime 57% in the area-time2 stock when compared with the lately planned radix-8 multiplier.
Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital (2018)

Our study reinforces the importance of monitoring the consumption of antifungal agents, which helps in proposing actions that lead to their rational use and, consequently, reduces the appearance of resistant strains.
Adhesion of Single Wall Carbon Nanotubes to a Copper Substrate by Means of a Self-Assembly Monolayer as Lithium-Ion Battery Anodes (2010)

Abstract not Available.
Introduction and overview (2020)

Economic reform since 1978 has led to an unprecedented growth in the history of population and economic development in China. A large portion of the increased urban population and the corresponding economic growth has been concentrated in the mega-city regions, such as Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (YRD) and Pearl River Delta (PRD). These three largest mega-city regions in China accounted for only 5% of the land area, but possessed 24.1% of the population and over 38.6% of the GDP of the national total in 2018. The importance of mega-city regions in China can be manifested in the 13th Five-year Plan (2016–2020) in which 19 urban agglomerations have been explicitly identified as national engines of urbanization and economic growth. Most of these urban agglomerations are mega-city regions. In this context, a series of reviews and case studies are presented in this book to explore the dynamics and challenges of economic, social, transport, environment and governance of mega-city region development in China, so that appropriate strategies can be formulated to facilitate their future planning and development. As an introductory chapter of the book, this chapter first conceptualizes mega-city regions and revisits their emergence in China. Then it proceeds to summarize the pathway and dynamics of mega-city region development during the three consecutive waves of economic transition since 1978. Thereafter, the chapter provides an overview of the whole book and summarizes the theoretical standpoints, research questions and objectives, and main findings of the 14 studies presented in the remaining chapters.
Seafloor Production Tools for the Resources of the Future (2011)

Abstract Soil Machine Dynamics (SMD) is one of the world's leading subsea engineering companies specialising in the design, manufacture, assembly and marinisation of equipment for the oil and gas, telecommunications, defence, scientific, renewable and mining sectors. The company has progressively developed since 1971, quickly gaining a reputation for supplying innovative equipment for the burial of pipelines and cables. In 2003, with the acquisition of Hydrovision, we entered the work-class ROV market. Further growth led to the recent acquisition of Hallin Robotics and an expansion from our deep-sea trenching skills base into seafloor mining equipment. This paper focuses on the design of Seafloor Production Tools (SPT's) for Nautilus Minerals Inc.(NMI)'s Solwara 1 copper/gold deposits in the Bismarck Sea, off Papua New Guinea. The design solutions adopted are described, highlighting advances and adaptations to existing mining and dredging technology. In particular, the paper focuses on the solutions developed to overcome challenges relating to;specific operating conditions in the Bismarck Sea,marinisation of heavy duty mining equipment for deep-sea operation,remote control of machines and pilot interfaces,interfaces with Nautilus' Production Support Vessel (PSV) and Subsea Lifting Pumps (SSLP). This project is undoubtedly one of the most exciting offshore engineering projects currently being undertaken. There has been keen interest from subsea, mining and dredging component suppliers and a high level of cross-industry cooperation since the start of the project. The technology described will help encourage subsea mining companies to seek out new deposits and cross resource frontiers that were hitherto considered as inaccessible. Introduction As economic surface resources are gradually depleted, the search for replacement mineral commodities is shifting towards new environments. SMD's client, Nautilus Minerals Inc. is a pioneer in the exploration of the seafloor to find economically attractive massive sulphide deposits. As Nautilus's exploration programme releases more geological and geotechnical detail and mining plans become firmer, the design of tools to exploit the sulphide deposits is being refined. Material strengths- accounting for estimates of hyperbaric effects- are within the bounds of the strength of materials already excavated by subsea Rock Trenchers previously designed and built by SMD, such as " RT1??.
Reported Cases of Human Plague Infections in the United States, 1970–1991 (1993)

From 1970 to 1991, 295 indigenous cases and one imported case of human plague were reported in the United States. Eighty-two percent of the total indigenous cases occurred in New Mexico, Arizona, and Colorado. Ninety-three percent of these cases had onset in the months of April through November. Most cases (89%) presented as bubonic or septicemic plague, or both. Cases were reported more frequently in males (58%), and male mortality exceeded that of females (17 versus 11%). Ground squirrels were the most frequently implicated sources of infection in cases associated with flea bites, and domestic cats were found to play an increasingly important role in transmission of disease to humans during these decades.
Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions (2017)

Papillomaviruses are small, double-stranded DNA viruses that encode the E2 protein, which controls transcription, replication, and genome maintenance in infected cells. Posttranslational modifications (PTMs) affecting E2 function and stability have been demonstrated for multiple types of papillomaviruses. Here we describe the first phosphorylation event involving a conserved tyrosine (Y) in the bovine papillomavirus 1 (BPV-1) E2 protein at amino acid 102. While its phosphodeficient phenylalanine (F) mutant activated both transcription and replication in luciferase reporter assays, a mutant that may act as a phosphomimetic, with a Y102-to-glutamate (E) mutation, lost both activities. The E2 Y102F protein interacted with cellular E2-binding factors and the viral helicase E1; however, in contrast, the Y102E mutant associated with only a subset and was unable to bind to E1. While the Y102F mutant fully supported transient viral DNA replication, BPV genomes encoding this mutation as well as Y102E were not maintained as stable episomes in murine C127 cells. These data imply that phosphorylation at Y102 disrupts the helical fold of the N-terminal region of E2 and its interaction with key cellular and viral proteins. We hypothesize that the resulting inhibition of viral transcription and replication in basal epithelial cells prevents the development of a lytic infection. Importance Papillomaviruses (PVs) are small, double-stranded DNA viruses that are responsible for cervical, oropharyngeal, and various genitourinary cancers. Although vaccines against the major oncogenic human PVs are available, there is no effective treatment for existing infections. One approach to better understand the viral replicative cycle, and potential therapies to target it, is to examine the posttranslational modification of viral proteins and its effect on function. Here we have discovered that the bovine papillomavirus 1 (BPV-1) transcription and replication regulator E2 is phosphorylated at residue Y102. While a phosphodeficient mutant at this site was fully functional, a phosphomimetic mutant displayed impaired transcription and replication activity as well as a lack of an association with certain E2-binding proteins. This study highlights the influence of posttranslational modifications on viral protein function and provides additional insight into the complex interplay between papillomaviruses and their hosts.
Novel FD SOI Devices Structure for Low Standby Power Applications (2006)

In this paper, full-depleted SOI devices with source/drain extension shift and high-κ offset spacer were investigated in detail. The calculated results show that the source/drain extension shift can decrease off-state leakage current Ioff significantly by utilizing the extra electron barrier height in source/drain extension shift region to reduce standby power dissipation. However, the on-state driving current Ion is also sacrificing simultaneously. In order to overcome this drawback, the high-κ offset spacer is used to increase the on-state driving current Ion effectively due to the enhanced vertical fringing electric field to elevate the channel voltage drop and reduce series resistance. Consequently, a nanoscale FD SOI device with 8-nm S/D extension shift and TiO2 offset spacer can possess high driving current Ion and ultra-low leakage current Ioff about 0.003 times lower than conventional SOI structure.
Préface (2020)

La vallée du Rhône, un espace si fragmenté et si cohérent à la fois, une vieille frontière d’Empire parcourue d’incessantes circulations d’hommes, de marchandises, d’idées… et d’armées. L’une de ces dernières, équipée par la Convention nationale, vint y rétablir son ordre révolutionnaire à l’été 1793. Tandis que Kellermann assiégeait Lyon, l’armée des Alpes commandée par le général Carteaux progressait vers le sud, de Valence jusqu’à Marseille, pour y réduire les rebelles. À l’arrivée des tro...
Percent reduction in LDL cholesterol following high-intensity statin therapy: potential implications for guidelines and for the prescription of emerging lipid-lowering agents (2016)

As documented for low- and moderate-intensity regimens, variability in % LDLC reduction following high-intensity statin therapy is wide yet the magnitude of this % reduction directly relates to efficacy. These data support guideline approaches that incorporate % reduction targets for statin therapy as well as absolute targets, and might provide a structure for the allocation of emerging adjunctive lipid-lowering therapies such as PCSK9 inhibitors should these agents prove broadly effective for cardiovascular event reduction.
Estimation and identification of two-dimensional images (1983)

Estimation of image pixel density can be performed using a reduced update Kalman filter provided that a mathematical model for the image generating process is available. To this effect various algorithms suitable for identifying the parameters of autoregressive image models are discussed and evaluated in terms of the mean-squared error between the true and filtered images. Algorithms considered include general and bias-compensated least-square procedures, a correlation-based algorithm, and procedures involving the simultaneous estimation of both the image model coefficient vector and pixel estimates. Experiments using two real images and two random fields indicate that bias-compensated least squares and correlation-based procedures might be most useful for image identification and adaptive filtering.
Serial concatenation of interleaved codes: performance analysis, design, and iterative decoding (1998)

A serially concatenated code with interleaver consists of the cascade of an outer encoder, an interleaver permuting the outer codewords bits, and an inner encoder whose input words are the permuted outer codewords. The construction can be generalized to h cascaded encoders separated by h-1 interleavers. We obtain upper bounds to the average maximum-likelihood bit error probability of serially concatenated block and convolutional coding schemes. Then, we derive design guidelines for the outer and inner encoders that maximize the interleaver gain and the asymptotic slope of the error probability curves. Finally, we propose a new, low-complexity iterative decoding algorithm. Throughout the paper, extensive comparisons with parallel concatenated convolutional codes known as "turbo codes" are performed, showing that the new scheme can offer superior performance.