Challenges in an ever changing climate (2008)

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate-An Overview K. Gadamasetti Emerging Trends in Process Chemistry T.F. Braish, F. De Knaep, and K. Gadamasetti Varenicline: Discovery Synthesis and Process Chemistry Developments J.W. Coe, H.A. Watson Jr., and R.A. Singer The SUTENT(R) Story R. Vaidyanathan An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist C. Savarin, J. Chung, J.A. Murry, R.J. Cvetovich, C. McWilliams, D. Hughes, J. Amato, G. Boice, K. Conrad, E. Corley, R. Reamer, and L. DiMichele Process Research and Development of LY414197, a 5HT2B Antagonist A. Borghese and A. Merschaert To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant H. J.Federsel and A. Sveno Chiral Amine Synthesis-Strategies, Examples, and Limitations T.C. Nugent Unnatural Amino Acids D.J. Ager The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862 C.P. Ashcroft, S. Challenger, A.M. Derrick, Y. Hajikarimian, and N.M. Thomson Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals T. Norris The Lithium-Halogen Exchange Reaction in Process Chemistry W.F. Bailey and T.L. Rathman Oxetan-3-one: Chemistry and Synthesis G. Wuitschik, E.M. Carreira, M. Rogers-Evans, and K. Muller Well-Defined (NHC)Pd (II) Complexes and Their Use in C-C and C-N Bond-Forming Reactions O. Navarro and S.P. Nolan Toward Truly Efficient Organic Reactions in Water C. Ogawa and S. Kobayashi The Chemical Development of the Commercial Route to Sildenafil Citrate P.J. Dunn Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds R.L. Hanson Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients-From Art to Science D. Wieckhusen In Situ Mid-Infrared Spectroscopy for Process Development D.A. Conlon, W. Izzo, J. Christopher McWilliams, R.A. Reamer, F. Xu, and P. Collins Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation-Homoaldol Reaction J.C. McWilliams and R.A. Reamer Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism F. Xu Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend(R)) D.A. Conlon, W. Izzo, and P. Collins Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals-Promise, Practice, and Challenges C.A. Mojica and L. St. Pierre-Berry PEGylation of Biological Macromolecules J.J. Buckley, R.F. Finn, J. Mo, L.A. Bass, and S.V. Ho Microwave Technology in Process Optimization F. Mavandadi Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture S. Casnocha, R. Fedechko, P. Mensah, J. Mott, and S. Nema Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps N. Zotova, S.P. Mathew, H. Iwamura, and D.G. Blackmond Trends in Outsourcing J. Lu and I. Shinkai Sourcing Pharmaceutical Products in China and India D. Robins and S. Hannon Index