gebhart/patrepeval huggingface dataset:
Sleep Extension in Humans: Sleep Stages, EEG Power Spectra and Body Temperature (1991)

In eight male subjects the electroencephalogram (EEG) and core body temperature (Tcore) were recorded during long sleep episodes from 0000 to 1,500 hr. EEGs were visually scored and subjected to spectral analysis by fast Fourier transform. Slow-wave sleep [SWS, i.e. stages 3 + 4 of non-rapid eye movement (NREM) sleep and slow wave activity (SWA, mean EEG power density in the range of 0.75-4.5 Hz)] in NREM sleep attained highest values in the first 3 hr of sleep and lowest values in the morning hours when rapid eye movement (REM) sleep was at its maximum. Wakefulness was significantly enhanced in the last 3 hr of the recording period. Occasional NREM episodes containing SWS were observed in the late morning and early afternoon. However, no significant increase in SWS or SWA in the last 3 hr of the sleep episode over any of the preceding 3-hr intervals was present and SWA in this interval was significantly below the values observed at the beginning of sleep. The duration of NREM episodes varied significantly over the sleep episode. Analysis of the dynamics of SWA within NREM episodes revealed that SWA gradually rose during the episode. Consequently, SWA averaged per episode was positively correlated with episode duration. Tcore dropped in the initial part of sleep, rose during the morning hours and reached values in the afternoon that were higher than at the beginning of sleep. Thus the time course of Tcore dissociated from the time course of SWA. This indicates that SWA in NREM sleep is not directly related to the variation in core body temperature.
MicroRNA-132-3p, Downregulated in Myeloid Angiogenic Cells from Hereditary Hemorrhagic Telangiectasia Patients, Is Enriched in the TGFβ and PI3K/AKT Signalling Pathways (2022)

MiRNA dysregulation, specifically reduced expression of miR-132-3p, in HHT MACs was identified. The dysregulated miRNAs are significantly enriched in the TGFβ, PI3K/AKT, and Hippo signalling pathways. These data suggest that alteration in miRNA expression may impair these pathways and contribute to MAC dysfunction in HHT.
Design of a Quench Device for Synthesis and Hydrolysis of Zn Nanoparticles: Flow Modeling and Experiments (2008)

The synthesis and hydrolysis of zinc nanoparticles are carried out in a tubular reactor. A key component of the reactor is a coaxial jet quench device. Three co-axial and multi-inlet confined jets mix Zn(g), steam and argon to produce and hydrolyze zinc nanoparticles. The performance of the quench device is assessed with computational fluid dynamic modeling and measurements of hydrogen conversion and particle size and composition. Numerical data elucidate the impact of varying jet flow rates on temperature and velocity distributions within the reactor. Experiments produce hydrogen conversions of 61 to 79%. Particle deposition on sections of the reactor surface above 650 K favors hydrolysis. Residence time for in-flight particles is less than one second and these particles are partially hydrolyzed.
Oxalyl Amide Assisted Palladium-Catalyzed Arylation of C(sp2)–H Bond at the δ Position (2014)

A successful protocol has been developed for δ-arylation of β-arylethamines at the ortho position under mild conditions. The newly developed methodology first presents broad substrate scope, great functional group tolerance, and good to excellent yield in the synthesis of substituted β-arylethylamines. The transformation represents a practical advantage of oxalyl amide in assistance with C-H functionalization at a remote position.
Influence of different components of data error on the result of solving identification and approximation problems (2020)

Abstract The dependences of approximation and identification errors for solving problems of approximation of functions associated with the presence of various components of data errors in the numerical solution are investigated. Using the study of problems that have an exact solution, we found patterns of increasing errors associated with rounding numbers and conditionality of the matrix of the equations system. It is shown that the error of identification (finding the coefficients of representation of the desired function as the linear combination of the basic ones) can be significantly greater than the error of approximation, despite the fact that the second one was estimated using crude values of the coefficients. The found dependencies limit the accuracy of the solution for approximation of other functions. Artificial distortion of the original data by random error is applied. It is shown that the identification error increases rapidly with increasing degree of approximation polynomial and significantly exceeds the amount of distortion. It is also shown that an increase in the number of specified points leads to a decrease of identification and approximation errors caused by random perturbation, inversely proportional to the number of points. Using examples of approximation of various functions, it is shown that the result of approximation, and especially identification, significantly depends on the convergence of the Taylor series (or its absence) on the segment under consideration.
Clustering-based dynamic bandwidth allocation for point-to-multipoint coherent optics (2023)

This article introduces a modified version of clustering techniques that can be applied in traffic aggregation for point-to-multipoint optical network architectures employing digital subcarrier multiplexing. The algorithm dynamically assigns individual subcarriers to nodes with uncorrelated traffic profiles.
Novel α 1 ‐adrenergic receptor signaling pathways: Secreted factors and extracellular matrix regulate cell adhesion, motility and transcription (2006)

α 1 ‐adrenergic receptor (α 1 ‐ARs) subtypes (α 1A , α 1B and α 1D ) regulate multiple signal pathways such as PLC, PKC, and MAPKs. We employed microarray technology to explore the effects of both short (1h) and long‐term (18h) activation of the α 1A ‐AR to enable RNA changes to occur downstream of earlier well‐characterized signaling pathways, promoting novel couplings. PCR studies confirmed that PKC was a critical regulator of gene expression with secreted growth factors (IL‐6, FGF7) also contributing to expression alterations. We next focused on two novel pathways that may be mediated through α 1A ‐AR stimulation, due to the clustering of gene expression changes for cell adhesion/motility (syndecan‐4 and tenascin‐C) and hyaluronan (HA) signaling. We confirmed that α 1 ‐ARs mediated vitronectin‐dependent cell adhesion in three cell types that was also integrin and FGF7‐dependent. α 1 ‐AR activation also inhibited cell migration, which was substrate‐independent suggesting regulation of cell motility. α 1 ‐AR activation also increased the expression and deposition of HA, a glycosaminoglycan, which displayed two distinct structures: pericellular coats and long cable structures, as well as increasing expression of the HA receptor, CD44. Since long cable structures of HA can bind leukocytes, this suggests that α 1 ‐ARs may be involved in pro‐inflammatory responses. Our results indicate α 1 ‐ARs interact with the extracellular matrix to regulate cell adhesion, motility and pro‐inflammatory responses through novel signaling pathways.
The Isoengine: A Novel High Efficiency Engine With Optional Compressed Air Energy Storage (CAES) (2003)

A novel high efficiency reciprocating piston engine — the isoengine — is predicted to achieve net electrical efficiencies of up to 60% in units of 5 to 20 MWe size. The high efficiency and at the same time a high specific power output are achieved by integrating isothermal compression, recuperative preheating and isobaric combustion into a novel power cycle. The isoengine can utilize distillate oil, natural gas or suitable biofuels. While the first commercial isoengine is envisaged to have a power output of 7 MW, a 3 MW prototype engine is currently being tested. Since compression and combustion are performed in different cylinders, these processes can also be performed at different times such that the isoengine can be used to create a highly efficient small-scale compressed air energy storage (CAES) system. In such configuration, the engine can operate at more than 140% nominal load for a limited time, which depends on the air storage capacity.
Dataset on the solid-liquid separation of anaerobic digestate by means of wood ash-based treatment (2022)

Wood bottom and fly ashes were added to the anaerobic digestate using sulfuric, hydrochloric, nitric, and lactic acids, as pH conditioners and sorption activating agents. Minimum (pH of zero-point charge), mild, and severe acidification of the samples were tested. The solid-liquid separation achieved was accounted visually and with the measurement of the masses of water-soluble extract and water-insoluble material isolated. The average mass of the blend was 36.61 ± 0.68 g, including the extractant agent that was prepared with the commercial acids and ultrapure milli-Q<sup>Ⓡ</sup> water. During the 144-h incubation of the mixtures at 20 °C and 0.17 x g, the shares of the solid and liquid were determined by centrifugation of the destructive samples at 3,130.40 x g for 5 minutes and 3-µm filtration of the supernatant. Before weighing the water-insoluble material, both the pellet that remained in the tube and the filter cake were dried at 70 °C until reaching constant weight. There was a significant increase in the amount of water-insoluble phase of the wood bottom ash due to the activation with lactic and sulfuric acids. The treatment of the wood fly ash and the agrowaste digestate with the hydrochloric acid showed an increase in the formation of water-soluble extract, in direct relation with the acidic pH of the blend. The characterization of the pH of the WS extract was performed with a Mettler Toledo<sup>Ⓡ</sup> Seven Compact<sup>TM</sup> S220 pH/Ion meter. The conditions of this process can be further optimized and each of the fractions can be characterized, in terms of nutrient content, to confirm the efficiency of the separation. More complex and ambitious processes can be designed for combining the wood ash and the anaerobic digestate. The performance of this treatment involving wood ashes and commercial acids can be extrapolated to other type of organic manures with a moisture content of approximately 95%, to improve their management in terms of reducing the cost of storage and transportation for land application below £5 per tonne.
Human Beta-defensins: Differential Activity against Candidal Species and Regulation by Candida albicans (2005)

Oral epithelial cell-derived human beta-defensins-1, -2, and -3 participate in innate immune responses against Candida. We hypothesized that these peptides utilize several mechanisms for protection. Recombinant hBD-1 and -2 were produced with the use of an insect cell/baculovirus expression system, while rhBD-3 was expressed as a fusion protein in E. coli. RhBD-2 and -3 were more effective at killing the candidal species at low micromolar concentrations than was rhBD-1, except for C. glabrata. While this species was relatively resistant to rhBD fungicidal activity, its adherence to oral epithelial cells was strain-specifically inhibited by the rhBDs. C. albicans hyphae were important in regulating hBD2 and -3 mRNA expression in primary human oral epithelial cells. Confocal microscopy of rhBD-2-challenged C. albicans suggests disruption of the fungal membrane. Results support the hypothesis that hBDs control fungal colonization through hyphal induction, direct fungicidal activity, and inhibition of candidal adherence.
Practical Problems Arising in the Solution of Polynomial Equations (1971)

Practical Problems Arising in the Solution of Polynomial Equations Get access G. PETERS, G. PETERS Department of Numerical and Applied Mathematics, National Physical LaboratoryTeddington, Middlesex, England Search for other works by this author on: Oxford Academic Google Scholar J. H. WILKINSON J. H. WILKINSON Department of Numerical and Applied Mathematics, National Physical LaboratoryTeddington, Middlesex, England Search for other works by this author on: Oxford Academic Google Scholar IMA Journal of Applied Mathematics, Volume 8, Issue 1, August 1971, Pages 16–35, https://doi.org/10.1093/imamat/8.1.16 Published: 01 August 1971 Article history Received: 26 June 1970 Published: 01 August 1971
Search for resonances decaying into photon pairs in 139 fb−1 of pp collisions at s=13 TeV with the ATLAS detector (2021)

Searches for new resonances in the diphoton final state, with spin 0 as predicted by theories with an extended Higgs sector and with spin 2 using a warped extra-dimension benchmark model, are presented using 139 fb -1 of s = 13 TeV pp collision data collected by the ATLAS experiment at the LHC. No significant deviation from the Standard Model is observed and upper limits are placed on the production cross-section times branching ratio to two photons as a function of the resonance mass.
EFFECTS OF VASCULAR OCCLUSION ON MUSCULAR ENDURANCE IN DYNAMIC KNEE EXTENSION EXERCISE AT DIFFERENT SUBMAXIMAL LOADS (2006)

Strength training with low load under conditions of vascular occlusion has been proposed as an alternative to heavy-resistance exercise in the rehabilitation setting, when large forces acting upon the musculoskeletal system are unwanted. Little is known, however, about the relative intensity at which occlusion of blood flow significantly reduces dynamic muscular endurance and, hence, when it may increase the training effect. The purpose of this study was to investigate endurance during dynamic knee extension at different loads with and without cuff occlusion. Sixteen subjects (20–45 years of age) with strength-training experience were recruited. At 4 test sessions, the subjects performed unilateral knee extensions to failure with and without a pressure cuff around the thigh at 20, 30, 40, and 50% of their 1 repetition maximum (1RM). The pressure cuff was inflated to 200 mm Hg during exercise with occlusion. Significant differences in the number of repetitions performed were found between occluded and nonoccluded conditions for loads of 20, 30, and 40% of 1RM (p < 0.01) but not for the 50% load (p = 0.465). Thus, the application of a pressure cuff around the thigh appears to reduce dynamic knee extension endurance more at a low load than at a moderate load. These results may have implications regarding when it could be useful to apply a tourniquet in order to increase the rate of fatigue and perhaps also the resulting training effect. However, the short- and long-term safety of training under ischemic conditions needs to be addressed in both healthy and less healthy populations. Furthermore, the high acute pain ratings and the delayed-onset muscle soreness associated with this type of training may limit its potential use to highly motivated individuals.
A Patient with Crimean-Congo Hemorrhagic Fever Serologically Diagnosed by Recombinant Nucleoprotein-Based Antibody Detection Systems (2003)

We treated a male patient with Crimean-Congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin G (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.
A multimode equivalent network approach for the analysis of a "realistic" finite array of open ended waveguides (2003)

In this contribution we present a theoretical model for the analysis of finite arrays of open-ended waveguides mounted on finite mounting platforms or having radome coverages. This model is based on a Multi-mode Equivalent Network (MEN) representation of the radiating waveguides complete with their tuning and exciter elements and a high frequency description of the external region.
Heterogeneous Phase Microwave-Assisted Reactions under CO2 or CO Pressure (2016)

The present review deals with the recent achievements and impressive potential applications of microwave (MW) heating to promote heterogeneous reactions under gas pressure. The high versatility of the latest generation of professional reactors combines extreme reaction conditions with safer and more efficient protocols. The double aims of this survey are to provide a panoramic snapshot of MW-assisted organic reactions with gaseous reagents, in particular CO and CO₂, and outline future applications. Stubborn and time-consuming carbonylation-like heterogeneous reactions, which have not yet been studied under dielectric heating, may well find an outstanding ally in the present protocol.
Effects of Polyphosphates on the Solubility and Mineralization of HA: Relevance to a Rationale for Anticaries Activity (1977)

Preexposure of hydroxyapatite (HA) to polyphosphate reduced the near-equilibrium acid solubility of HA, the mineralization of HA, and the exchange of PO4 between medium and HA. Appreciably longer exposure times were required for maximal effects of trimetaphosphate (TMP) than of pyrophosphate (PP), tripolyphosphate (TPP), and hexametaphosphate (HMP). Calcifying solution solubilized small amounts of the HA-bound polyphosphates. This occurred to the smallest extent in the case of TMP, a fact which could have relevance for the superior anticaries effect of TMP.
Asymmetric Allylic C–H Alkylation via Palladium(II)/cis-ArSOX Catalysis (2018)

We report the development of Pd(II)/ cis-aryl sulfoxide-oxazoline ( cis-ArSOX) catalysts for asymmetric C-H alkylation of terminal olefins with a variety of synthetically versatile nucleophiles. The modular, tunable, and oxidatively stable ArSOX scaffold is key to the unprecedented broad scope and high enantioselectivity (37 examples, avg. > 90% ee). Pd(II)/ cis-ArSOX is unique in its ability to effect high reactivity and catalyst-controlled diastereoselectivity on the alkylation of aliphatic olefins. We anticipate that this new chiral ligand class will find use in other transition metal catalyzed processes that operate under oxidative conditions.
Circulating Angiogenic T Cells and Their Subpopulations in Patients with Systemic Lupus Erythematosus (2016)

Anti-dsDNA-positivity may identify a group of SLE patients with increased Tang cell subsets and circulating CD8+ Tang cells may be viewed as a potentially useful biomarker of endothelial damage and cardiovascular risk in SLE.
Digitalization Platform for Mechanistic Modeling of Battery Cell Production (2022)

The application of batteries in electric vehicles and stationary energy-storage systems is widely seen as a promising enabler for a sustainable mobility and for the energy sector. Although significant improvements have been achieved in the last decade in terms of higher battery performance and lower production costs, there remains high potential to be tapped, especially along the battery production chain. However, the battery production process is highly complex due to numerous process–structure and structure–performance relationships along the process chain, many of which are not yet fully understood. In order to move away from expensive trial-and-error operations of production lines, a methodology is needed to provide knowledge-based decision support to improve the quality and throughput of battery production. In the present work, a framework is presented that combines a process chain model and a battery cell model to quantitatively predict the impact of processes on the final battery cell performance. The framework enables coupling of diverse mechanistic models for the individual processes and the battery cell in a generic container platform, ultimately providing a digital representation of a battery electrode and cell production line that allows optimal production settings to be identified in silico. The framework can be implemented as part of a cyber-physical production system to provide decision support and ultimately control of the production line, thus increasing the efficiency of the entire battery cell production process.
Macrophage activation syndrome in a 74 years old man (1998)

Monsieur L., âge de 74 ans, est hospitalise en septembre 1997 pour des lombalgies de caractere inflammatoire evoluant depuis 2 mois. Un diagnostic de lymphome malin non hodgkinien avait ete porte en 1991 apres la biopsie d'une masse retroperitoneale realisee au cours d'une laparotomie exploratrice, dans le cadre du bilan d'une masse epigastrique decouverte fortuitement. Il s'agissait d'un lymphome malin folliculaire diffus a predominance de petites cellules clivees type « B » de la Working Formulation, dont la seule localisation etait cette masse retroperitoneale. Une remission complete avait ete obtenue apres sept cures de chlorambucil et corticoides. Au cours de l'hospitalisation de septembre 1997, le bilan des lombalgies comprend des cliches radiologiques standards, puis une IRM lombaire qui mettent en evidence une epidurite en regard des premiere et deuxieme vertebres lombaires associee a des lesions des corps vertebraux evoquant un processus tumoral. La palpation abdominale retrouve des masses dans la region para-ombilicale. Une tomodensitometrie abdominale confirme la presence de volumineuses adenopathies cœlio-mesenteriques et retroperitoneales avec des dilatations des cavites pyelocalicielles. Ces adenopathies sont ponctionnees sous scanner, permettant de poser le diagnostic de recidive du lymphome avec transformation en grandes cellules. La biopsie medullaire ne montre pas de proliferation tumorale. Il est decide d'entreprendre une chimiotherapie de type CHOP (cyclophosphamide, adriamycine, vincristine, prednisone) programmee pour six cures avec une periodicite de 28 jours.
Prevalence of molar incisor hypomineralization among school children in Rome, Italy (2022)

Molar incisor hypomineralization (MIH) is a highly prevalent condition associated with increased caries experience, dental pain and treatment need. Aim of this study was to determine the prevalence and severity of MIH in a group of 7-8 years old primary school children living in Rome, Italy; and to assess the association with caries experience and possible perinatal risk factors. A survey has been conducted in the city of Rome, between April 2019 and March 2020 with a total of 49 primary schools and 176 2nd grade primary school classes and a total of 3611 children being involved. Of these, a subset of 346 children of 21 primary schools was selected for the epidemiological investigation. The prevalence of MIH was of 18.2%, with girls showing twice the probability of being subject to a mild-severe condition. Molar location was present in 71.4%, while location on both molar plus incisor was present in 28.6% of cases. The mean DMFT was 0.44 ± 0.78, "D" was 0.17 ± 0.58; the mean dmft was 1.7 ± 2.56, "d" was 1.32 ± 2.21. Female gender, caries experience, insufficient oral hygiene were risk factors. The incidence of MIH is increasing in the pediatric population. Knowledge about diagnosis and treatment options should be disseminated among dental professionals.