gebhart/patrepeval huggingface dataset:
Phase matched optical dielectric waveguide using the artificial anisotropic structure (1983)

Abstract Birefringent material in a thin film dielectric waveguide is used to realize phase matching of the waves with different polarizations. However, this method cannot be used exclusively due to lattice mismatch as happens in a mode conversion type isolator. This paper proposes an artificial anisotropic waveguide realizing phase matching with isotropic dielectric materials only. the structure is a slab waveguide loaded with dielectric strips parallel to the wave propagation direction. This structure can equalize the phase velocities of the E x and E y modes. A numerical analysis based on the mode matching technique is used to obtain the phase match condition. the effect of an artificial anisotropy is confirmed in a waveguide fabricated in experiments. A waveguide is realized in which difference of the propagation constants of the E x and E y modes is extremely small. It is believed possible that a thin film optical isolator can be reproduced with this waveguide.
Les médias québécois (Marc Raboy et André Roy) (1993)

Proulx Serge. Les médias québécois (Marc Raboy et André Roy) . In: Réseaux, volume 11, n°59, 1993. Droit et communication. pp. 135-137.
Extending data mining techniques for frequent pattern discovery: Trees, low-entropy sets, and crossmining (2010)

The idea of frequent pattern discovery is to find frequently occurring events in large databases. Such data mining techniques can be useful in various domains. For instance, in recommendation and e-commerce systems frequently occurring product purchase combinations are essential in user preference modeling. In the ecological domain, patterns of frequently occurring groups of species can be used to reveal insight into species interaction dynamics. &#13;\n Over the past few years, most frequent pattern mining research has concentrated on efficiency (speed) of mining algorithms. However, it has been argued within the community that while efficiency of the mining task is no longer a bottleneck, there is still an urgent need for methods that derive compact, yet high quality results with good application properties. The aim of this thesis is to address this need. &#13;\n The first part of the thesis discusses a new type of tree pattern class for expressing hierarchies of general and more specific attributes in unstructured binary data. The new pattern class is shown to have advantageous properties, and to discover relationships in data that cannot be expressed alone with the more traditional frequent itemset or association rule patterns. &#13;\n The second and third parts of the thesis discuss the use of entropy as a score measure for frequent pattern mining. A new pattern class is defined, low-entropy sets, which allow to express more general types of occurrence structure than with frequent itemsets. The concept can also be easily applied to tree types of pattern. Furthermore, by applying minimum description length in pattern selection for low-entropy sets it is shown experimentally that in most cases the collections of selected patterns are much smaller than by using frequent itemsets. &#13;\n The fourth part of the thesis examines the idea of crossmining itemsets, that is, relating itemsets to numerical variables in a database of mixed data types. The problem is formally defined and turns out to be NP-hard, although it is approximately solvable within a constant-factor of the optimum solution. Experiments show that the algorithm finds itemsets that convey structure in both the binary and the numerical part of the data.
Gihon (Place) (1992)

[Heb gîḥôn]. The name of two sources of water; though it is possible that they are not independent of one another.1. According to three connected communications, an important spring in Jerusalem, presented as the place where Solomon is said to have been anointed king (cf. 1 Kgs 1:33, 38, 45). The co
Impact of the diagnosis and treatment of cancer on the course of inflammatory bowel disease (2014)

Occurrence of extra-intestinal cancer impacts IBD therapeutic management, with a trend towards less use of immunomodulators and more surgery. In the long-term, cancer diagnoses and treatments do not modify IBD outcomes.
Basic Design Concepts of Laminar Fluidic Digital Logic Elements Using Laminar Proportional Amplifiers With Positive Feedback (1979)

The basic design concepts of laminar digital logic elements using proportional amplifiers (LPA’s) with feekback are discussed. By using a decoupling amplifier, the input and output of these elements can be decoupled so that the switching threshold is independent of the output loading. Test results and theoretical predictions indicate that laminar digital logic elements with good performance characteristics can be designed by using LPA’s with feedback.
Multiple-Hypothesis Trilateration and Tracking with Distributed Radars (2006)

A novel algorithm to associate and trilaterate detections from multiple distributed radars is presented. The algorithm provides for flexible track state representations. The coordinate system of a track is switched from the measurement coordinates (range-Doppler) to cartesian coordinates when a detection from another sensor is associated to the track. In the case of multiple targets and false alarms we run into the complication of multiple association possibilities. These can be resolved by using a multi-hypothesis algorithm. In general, correctly formed tracks will have more likely associations. Therefore, hypotheses describing these tracks will be favored. Simulations with one or two targets and different false alarm rates show the need to preserve multiple hypotheses of the world state. Tracking performance for various false alarms rates is evaluated
Gender and Age Differences in Medications Dispensed from a National Chain Drugstore (2008)

Females, especially during the reproductive years, are dispensed more medications than males.
Development of Large Scale Particle Image Velocimetry Prototype for the Small Stream Discharge Monitoring (2017)

The Large Scale Particle Image Velocimetry (LSPIV) has been highlighted so far for measuring small stream flow discharge in terms of their high order...
Optimierung von generischen Operationen und Speicherstrukturen in Objekt-Datenbanken (1997)

Wesentliche Kriterien für den zukünftigen Erfolg oder Mißerfolg objekt-orientierter Datenbanksysteme werden die verfügbaren Konzepte und die Performance solcher Systeme sein. Die zur Zeit in kommerziellen Systemen verfügbaren Konzepte vernachlässigen beispielsweise Freiheitsgrade auf der physischen Ebene; zur Leistungssteigerung vorhandener Systeme ist es notwendig, das vorhandene Optimierungspotential aller Komponenten voll auszuschöpfen. Dieser Artikel beschreibt den Entwurf und die Realisierung eines objektorientierten Anfragebearbeitungssystems und Anfrageoptimierers auf Basis von OQL und ObjectStore. Dazu werden Plattformen wie objektorientierte Datenmodelle und deskriptive Anfragesprachen, Optimierungsansätze in objektorientierten Datenbankmanagementsystemen (OODBMS), Optimierungstechniken und unterstützende Maßnahmen wie Monoid-Kalküle, Speicherstrukturen, Suchstrategien sowie Kostenmodelle betrachtet und ihre Integration in einen einheitlichen Ansatz im Rahmen eines Forschungsprototypen diskutiert.
Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids (2015)

Bacterial pigments of the aryl polyene type are structurally similar to the well-known carotenoids with respect to their polyene systems. Their biosynthetic gene cluster is widespread in taxonomically distant bacteria, and four classes of such pigments have been found. Here we report the structure elucidation of the aryl polyene/dialkylresorcinol hybrid pigments of Variovorax paradoxus B4 by HPLC-UV-MS, MALDI-MS and NMR. Furthermore, we show for the first time that this pigment class protects the bacterium from reactive oxygen species, similarly to what is known for carotenoids. An analysis of the distribution of biosynthetic genes for aryl polyenes and carotenoids in bacterial genomes is presented; it shows a complementary distribution of these protective pigments in bacteria.
Leptin Treatment Induces Loss of Bone Marrow Adipocytes and Increases Bone Formation in Leptin-Deficient ob/ob Mice (2005)

Results indicate that both doses of leptin decreased the number of marrow adipocytes in ob/ob mice by >20% (p < 0.05) compared with PBS-treated ob/ob mice. The decrease in adipocyte number with leptin treatment is accompanied by an increase in concentration of the apoptosis marker caspase-3 in bone marrow adipocytes and hematopoietic cells. Both leptin doses also significantly (p < 0.05) increased the percentage of fluorochrome-labeled tibial endosteal surface by >30% compared with PBS-treated ob/ob mice. Leptin treatment increased whole body BMC by >30% in the ob/ob mice receiving the highest leptin dose. Leptin treatment provided no increase in bone formation, BMC, or BMD in normal, leptin-replete mice.
Self-organization and mechanical properties of active filament bundles (2003)

A general framework for the description of active bundles of polar filaments is presented. The activity of the bundle results from mobile cross-links that induce relative displacements between the aligned filaments. Our generic description is based on momentum conservation within the bundle. By specifying the internal forces, a simple minimal model for the bundle dynamics can be derived, capturing a rich variety of dynamic behaviors. In particular, contracted states as well as solitary and oscillatory waves appear through dynamic instabilities. We present the full bifurcation diagram of this model and study the effects of a dynamic motor distribution on the bundle dynamics. Furthermore, we discuss the mechanical properties of the bundle in the presence of externally applied forces. Our description is motivated by dynamic phenomena in the cytoskeleton and could apply to in vitro experiments as well as to stress fibers and to self-organization phenomena during cell locomotion.
Fire Properties of Refuse Derived Fuels: Measurements of Temperature Profiles and Mass Loss (2008)

Below is an excerpt of a recent article published by Engineering News Record describing recent efforts to rethink structural fire protection engineering for large, open-plan office spaces. 9/11 Blazes Debunk Code […]
Introduction: Biological Markers of Male Reproductive Toxicology (1987)

Reproduction is a complex, stepwise series of processes that begins with gametogenesis, continues through gamete interaction, implantation, embryonic development, growth, parturition, and postnatal adaptation, and is completed with the development and sexual maturation of the newly formed organism. These reproductive processes do not take place in a chemically pristine environment, but rather in an environment increasingly contaminated with the products and by-products of the chemical age in which we live. Some environmental pollutants are known to be carcinogenic, mutagenic, or toxic to the reproductive system, but most have not been adequately tested for reproductive toxicity. Just as reproduction is complex, biological mechanisms underlying toxicology are similarly complex and involve absorption, distribution, metabolism (toxification and/or detoxification), excretion, and repair. The synthesis of these sciences into the relatively nascent science of reproductive toxicology includes teratology, pharmacology, epidemiology, and occupational and environmental health. Female reproductive function (especially pregnancy outcome) has historically been the focus of attention, but there is increasing interest in the effects of chemical exposure on male reproductive function. Several reports have documented the physiology, biochemistry, and toxicology of male mammalian reproduction, and evaluated susceptibility of the male to the effects of exogenous chemicals (1-6).
Cyclic Nucleotide Signalling in Kidney Fibrosis (2015)

Kidney fibrosis is an important factor for the progression of kidney diseases, e.g., diabetes mellitus induced kidney failure, glomerulosclerosis and nephritis resulting in chronic kidney disease or end-stage renal disease. Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were implicated to suppress several of the above mentioned renal diseases. In this review article, identified effects and mechanisms of cGMP and cAMP regarding renal fibrosis are summarized. These mechanisms include several signalling pathways of nitric oxide/ANP/guanylyl cyclases/cGMP-dependent protein kinase and cAMP/Epac/adenylyl cyclases/cAMP-dependent protein kinase. Furthermore, diverse possible drugs activating these pathways are discussed. From these diverse mechanisms it is expected that new pharmacological treatments will evolve for the therapy or even prevention of kidney failure.
Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration (1996)

The ionic mechanisms by which dopamine (DA) regulates the excitability of layers V-VI prefrontal cortex (PFC) output neurons (including those that project to the nucleus accumbens) were investigated in rat brain slices using in vitro intracellular recording techniques. DA or the D1 receptor agonist SKF38393, but not the D2 agonist quinpirole, reduced the first spike latency and lowered the firing threshold of the PFC neurons in response to depolarizing current pulses. This was accomplished by enhancing the duration of a tetradotoxinsensitive, slowly inactivating Na+ current and attenuating a slowly inactivating, outwardly rectifying, dendrotoxin-sensitive K+ current. Furthermore, D1 receptor stimulation attenuated high-threshold Ca2+ spike(s) (HTS) evoked primarily from the apical dendrites of these PFC neurons. Taken together, these data suggest that D1 receptor stimulation on layers V-VI pyramidal PFC neurons: (1) restricts the effects of inputs to the apical dendrites of these neurons by attenuating the dendritic HTS-mediated amplification of such inputs; and (2) potentiates the influence of local inputs from neighboring deep layers V-VI neurons by enhancing the slowly inactivating Na+ current and attenuating the slowly inactivating K+ current. By influencing the input/output characteristics of PFC-->NAc neurons, DA may play an important role in the processes through which PFC signals are translated into action.
Significant Association Between Variant in SGCD and Age-Related Macular Degeneration (2018)

<i>CFH</i> and <i>HTRA1</i> genes are traditional markers of increased risk of age-related macular degeneration (AMD) across populations. Recent findings suggest that additional genes-for instance, in the dystrophin-associated protein complex-might be promising markers for AMD. Here, we performed a case-control study to assess the effect of <i>SGCD</i> single nucleotide polymorphisms (SNPs), a member of this protein family, on AMD diagnosis and phenotype. We performed a case-control study of an under-studied population from Hispanics in Mexico City, with 134 cases with 134 unpaired controls. Cases were 60 years or older (Clinical Age-Related Maculopathy Staging (CARMS) grade 4⁻5, as assessed by experienced ophthalmologists following the American Association of Ophthalmology (AAO) guidelines), without other retinal disease or history of vitreous-retinal surgery. Controls were outpatients aged 60 years or older, with no drusen or retinal pigment epithelium (RPE) changes on a fundus exam and a negative family history of AMD. We examined SNPs in the <i>SGCD</i> gene (rs931798, rs140617, rs140616, and rs970476) by sequencing and real-time PCR. Genotyping quality checks and univariate analyses were performed with PLINK v1.90b3.42. Furthermore, logistic regression models were done in SAS v.9.4 and haplotype configurations in R v.3.3.1. After adjusting for clinical covariates, the G/A genotype of the SGCD gene (rs931798) significantly increases the odds of being diagnosed with AMD in 81% of cases (1.81; 95% CI 1.06⁻3.14; <i>p</i> = 0.031), especially the geographic atrophy phenotype (1.82; 95% CI 1.03⁻3.21; <i>p</i> = 0.038) compared to the G/G homozygous genotype. Moreover, the GATT haplotype in this gene (rs931798, rs140617, rs140616, and rs970476) is associated with lower odds of AMD (adjusted odds ratio (OR) 0.13; 95% CI 0.02⁻0.91; <i>p</i> = 0.041). <i>SGCD</i> is a promising gene for AMD research. Further corroboration in other populations is warranted, especially among other Hispanic ethnicities.
Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury (2010)

Article Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury was published on January 1, 2011 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 49, issue 1).
Functional site of endogenous phospholipase A2 inhibitor from python serum (2002)

The functional site of 'phospholipase A2 inhibitor from python' (PIP) was predicted based on the hypothesis of proline brackets. Using different sources of secretory phospholipase A2 (sPLA2s) as enzyme, and [3H]arachidonate-labelled Escherichia coli as substrate, short synthetic peptides representing the proposed site were examined for their secretory phospholipase A2 (sPLA2) inhibitory activity. A decapeptide P-PB.III proved to be the most potent of the tested peptides in inhibiting sPLA2 enzymatic activity in vitro, and exhibited striking anti-inflammatory effects in vivo in a mouse paw oedema model. P-PB.III inhibited the enzymatic activity of class I, II and III PLA2s, including that of human synovial fluid from arthritis patients. When tested by ELISA, biotinylated P-PB.III interacted positively with various PLA2s, suggesting that the specific region of PIP corresponding to P-PB.III, is likely to be involved in the PLA2-PLI interaction. The effect of P-PB.III on the peritoneal inflammatory response after surgical trauma in rats was also examined. P-PB.III effectively reduced the extent of postsurgical peritoneal adhesions as compared to controls. sPLA2 levels at seventh postoperative day in the peritoneal tissue of P-PB.III-treated rats were also significantly reduced (P < 0.05) in comparison to those of the untreated controls. The present results shed additional insight on the essential structural elements for PLA2 binding, and may be useful as a basis for the design of novel therapeutic agents.
High dose mitoxantrone and melphalan followed by autologous stem cell transplantation for lymphoid malignancies (2006)

We evaluated outcomes in 44 patients with lymphoid malignancies who underwent autologous stem cell transplantation following a preparative regimen of mitoxantrone 20 mg/m2 over 1 hour × 3 (total dose 60 mg/m2) and melphalan 60 mg/m2 over 1 hour × 3 (total dose 180 mg/m2). Twelve patients (6 male) had nodular sclerosing (n = 9) or mixed cellularity (n = 3) Hodgkin’s Lymphoma (HL), while 32 patients (17 male) had diffuse large B-cell (n = 21), T-lymphoblastic (n = 4), mantle cell (n = 2), T cell rich B-cell (n = 1), or anaplastic large cell (n = 3) non-Hodgkin’s lymphoma (NHL). The median age among Hodgkin’s patients was 35 years (range 19–46 years) while the median age among NHL patients was 47 years (range 23–63 years). Two patients were in first complete remission (CR), 1 patient in CR2, while 15 patients had partial response, 14 patients had relapsed disease, and 12 patients had refractory disease at the time of transplant. All patients had a left ventricular ejection fraction of at least 40% at the time of transplant. Mitoxantrone and melphalan were well tolerated, with grade 3/4 mucositis the most common toxicity. Neutrophil engraftment was seen at the median of 13 days (range 8–34 days). Day 100 transplant related mortality (TRM) was 3%. The 3-year disease free (DFS) and overall survival (OS) were 63% and 67%, respectively. Three-year DFS were similar between HL and NHL patients (67% vs 63%: P = .66). There was no significant difference in 3-year DFS between patients with CR or PR versus relapsed or refractory disease (66% vs 62%: P = .96). DFS were similar among all disease subtypes. Congestive heart failure occurred in on 3 patients (7%). One patient died of complications from CHF while 2 others recovered cardiac function. In conclusion, mitoxantrone and melphalan preparative regimen is well tolerated with minimal cardiac toxicity in patients with lymphoid malignancies previously treated with anthracyclines.
Targeted Inactivation of Murine Band 3 (AE1) Gene Produces a Hypercoagulable State Causing Widespread Thrombosis In Vivo (1998)

Only 5% to 10% of band 3 null mice survive the neonatal period. To determine the cause of death, 3 adult and 11 newborn band 3 null mice were submitted for histopathologic examination. All but 1 pup showed evidence of thrombosis including: (1) large thrombotic lesions in the heart, which were partially organized, calcified in some fields, and endothelialized, indicating a process that developed premortem (3 of 3 adults and 6 of 11 pups). (2) Subcapsular necrotic areas in the liver suggestive of premortem ischemic events caused by arteriolar occlusions (8 of 11 pups). (3) Large vein thrombi (4 of 11 pups). To investigate the etiology of this hypercoagulable state, we have used the Russell’s viper venom test (RVV) to show that red blood cells (RBCs) from band 3 null mice significantly shorten the RVV clotting time of normal plasma in a dose-dependent fashion, whereas RBCs from normal mice have no effect, suggesting that the membrane of band 3 null RBCs provides a suitable surface for activation of the prothrombinase complex. Using flow cytometry, we have examined the phosphatidylserine (PS)-specific binding of fluorescein isothiocyanate (FITC)-annexin V to normal and band 3 null RBCs. A subpopulation of cells (3% to 5% of RBCs) with increased FITC-annexin V binding was detected in band 3 null RBCs as compared with normal RBCs. Furthermore, the entire cell population of band 3 null RBCs shows a measurable increase in the mean fluorescence intensity, suggesting that band 3 null RBCs may have increased PS exposure on the outer membrane leaflet. These findings are further supported by direct fluorescence microscopy of normal and band 3 null RBCs labeled with FITC-annexin V. Based on these observations, we postulate that the high mortality of band 3 null mice may be related to a hypercoagulable state, which appears to originate from changes in the phospholipid composition of the membrane leading to PS exposure on the outer leaflet. © 1998 by The American Society of Hematology.
A simple API to the knowledgestore (2014)

Abstract. RDF and SPARQL technologies have not gained widespread accep-tance amongst web developers. We describe a simple API which is used to pro-vide access to the KnowledgeStore, a scalable, fault-tolerant, and Semantic Web grounded storage system for interlinking structured and unstructured data, devel-oped in the contect of the FP7 NewsReader EU project. The simple API wraps a set of parameterised SPARQL queries to access the KnowledgeStore RDF structured content, and calls to the KnowledgeStore CRUD endpoint to retrieve unstructured resources. Responses are delivered as JSON, JSONP, HTML or CSV. The API is largely self-documenting. The API is written using the Flask Python library, and includes an extensive suite of tests. It is modular, so that new SPARQL queries can be added easily or it could be used as a template for providing an API to any SPARQL endpoint. The simple API was succesfully exploited by 38 web developers, many of them unfamiliar with RDF and SPARQL technologies, to build web applications on top of the KnowledgeStore.