gebhart/patrepeval huggingface dataset:
Standard handbook of biomedical engineering and design (2002)

Standard handbook of biomedical engineering and design , Standard handbook of biomedical engineering and design , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential (2010)

The reviewed studies provide promising results demonstrating fractalkine and CX3CR1 as potential target molecules for future therapeutics that may attenuate pain, inflammation and furthermore serve as an anti-cancer therapy. However, to date, no therapeutics targeting fractalkine or CX3CR1 are in clinical use.
Treibstoffe (Kapitel 3 der Vorlesung Chemische Raumfahrtantriebe I an der Universität Stuttgart) (2011)

Dieser Vortrag in einer Vorlesungsreihe gibt einen Uberblick uber das Gebiet der Treibstoffe
Vessel-associated myogenic precursors control macrophage activation and clearance of apoptotic cells (2014)

Swift and regulated clearance of apoptotic cells prevents the accumulation of cell remnants in injured tissues and contributes to the shift of macrophages towards alternatively activated reparatory cells that sustain wound healing. Environmental signals, most of which are unknown, in turn control the efficiency of the clearance of apoptotic cells and as such determine whether tissues eventually heal. In this study we show that vessel-associated stem cells (mesoangioblasts) specifically modulate the expression of genes involved in the clearance of apoptotic cells and in macrophage alternative activation, including those of scavenger receptors and of molecules that bridge dying cells and phagocytes. Mesoangioblasts, but not immortalized myoblasts or neural precursor cells, enhance CD163 membrane expression in vitro as assessed by flow cytometry, indicating that the effect is specific. Mesoangioblasts transplanted in acutely or chronically injured skeletal muscles determine the expansion of the population of CD163(+) infiltrating macrophages and increase the extent of CD163 expression. Conversely, macrophages challenged with mesoangioblasts engulf significantly better apoptotic cells in vitro. Collectively, the data reveal a feed-forward loop between macrophages and vessel-associated stem cells, which has implications for the skeletal muscle homeostatic response to sterile injury and for diseases in which homeostasis is jeopardized, including muscle dystrophies and inflammatory myopathies.
Studies on Pyrazines. Part 33.1 Synthesis of 2,3-Diaminopyrazines via [1,2,5]Thiadiazolo[3,4-b]pyrazines (1997)

N. Sato and H. Mizuno, J. Chem. Res. (S), 1997, 250 DOI: 10.1039/A701579H
HLODs for faster display of large static and dynamic environments (2001)

Article HLODs for faster display of large static and dynamic environments Share on Authors: Carl Erikson Univ. of North Carolina, Chapel Hill Univ. of North Carolina, Chapel HillView Profile , Dinesh Manocha Univ. of North Carolina, Chapel Hill Univ. of North Carolina, Chapel HillView Profile , William V. Baxter Univ. of North Carolina, Chapel Hill Univ. of North Carolina, Chapel HillView Profile Authors Info & Claims I3D '01: Proceedings of the 2001 symposium on Interactive 3D graphicsMarch 2001 Pages 111–120https://doi.org/10.1145/364338.364376Online:01 March 2001Publication History 64citation781DownloadsMetricsTotal Citations64Total Downloads781Last 12 Months17Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Satellite architecture [for autonomous on-orbit servicing] (2002)

This paper describes an effort to develop an avionics architecture that enables replacement of deficient satellite hardware on-orbit as well as upgrade/adapt on-orbit systems. It is anticipated that routine, safe, and reliable spacecraft servicing will have significant payoff for many future types of science and military missions. Satellites that are placed on-orbit and are functionally lost due to simple failures beg for the development of an on-orbit replacement capability. To date, this has been performed by an astronaut. Human intervention in space, however, carries risk and cost associated with it that would not be necessary if an autonomous satellite repair capability was developed. The associated capability to perform pre-planned upgrades and adaptations to on-orbit space assets also has the potential for architecting high performance future spacecraft. The first step in developing a serviceable satellite is to evolve the tightly integrated satellite architectures of today toward an architecture that supports functional and/or physical replacement of anomalous or failed hardware. Draper Laboratory has performed a trade study to develop a single-point architecture that provides a growth path from the functionally efficient satellite designs of today to a functionally reliable modular architecture that will support the autonomous on-orbit upgrade and functional enhancement of tomorrow's satellites. This paper presents an overview of an architecture that can enable autonomous satellite servicing.
Integrin alpha 4 / beta 1 (CD49d/CD29) is a component of the murine IgG3 receptor (2017)

Summary Antibodies exert several of their effector functions by binding to cell surface receptors. For murine IgG3 (mIgG3) the identity of its receptors (and the very existence of a receptor) is still under debate, as not all mIgG3 functions can be explained by interaction with Fcγ-receptor I (FcγRI). This implies the existence of an alternate receptor, whose identity we sought to pinpoint. We found that blockage of the alpha4/beta1 integrin (Itga4/Itgb1) selectively hampered binding of mIgG3 to macrophages and mIgG3-mediated phagocytosis. Manganese, an integrin activator, increased mIgG3 binding to macrophages. Blockage of FcγRI or Itgb1 inhibited binding of different mIgG3 antibodies to variable extents. Our results indicate an integrin component in the mIgG3 receptor. Given the more ancient origin of integrins in comparison with FcγR, this observation could have far ranging implications for our understanding of the evolution of antibody-mediated immunity, as well as in immunity to microorganisms, pathogenesis of autoimmune diseases and antibody engineering.
A mathematical model for predicting coupled heat and water movement in unsaturated soil (1978)

Abstract An investigation was conducted to develop a comprehensive moisture model for predicting non‐isothermal moisture conditions in soils. An extensive literature review indicated that a model based on the Philip and de Vries equations for non‐isothermal moisture movement and heat conduction would give the best results. By using numerical methods, the implicit finite difference approximations to the moisture movement and heat‐transfer equations were programmed for computer solution of water content and temperature in the soil with time. Validation studies indicate that the moisture model can be used to predict accurately moisture conditions in the soil. The model was validated by using hydraulic data from laboratory studies conducted on soil columns compacted with AASHO A‐3 and AASHO A‐4 soil. The application of the moisture model to the study of non‐isothermal moisture movement in the field is demonstrated. The influence of parameters such as water table depth, precipitation, and soil hydraulic properties on soil moisture content are shown by use of the moisture model. The model is shown to be applicable to a wide range of boundary conditions and that it predicts the moisture‐temperature regime with time in soils utilizing climatic input data.
Long-term monitoring of the urban impervious surface mapping using time series Landsat imagery: A 23-year case study of the city of Wuhan in China (2016)

Impervious surface is a significant indicator of urban environments. In order to better understand the pattern of urban expansion, this study adopted random forest algorithm for a long-term urban impervious surface mapping of Wuhan in China. We produced 23-year (1993 to 2015) urban impervious surface mapping data via a dense Landsat time series and the results indicated that the impervious surface area in Wuhan increased rapidly from 4.33% to 15.34% of the total land area from 1993 to 2015. Moreover these map showed that the loss of agricultural land plays a major role in the development of urbanization and impervious surface spread from center area to rural areas, and NDVI showed a higher influence than MNDWI and BCI. Specifically, it was a more important finding that obvious decreasing tendency within the old city zones when they are faced the transformation of old urban renewal. With respect to the formulation of the new urban area, the impervious surface percent can be regarded as an indication of land use because the number and distribution of urban impervious areas have a close and inter-annually correlation with land use/cover types. Finally, it was clearly that RF has a good performance to deal with massive data.
5.2 Energy-Efficient Low-Noise CMOS Image Sensor with Capacitor Array-Assisted Charge-Injection SAR ADC for Motion-Triggered Low-Power IoT Applications (2019)

As IoT is increasingly integrated into our everyday life, the demand for different sensor modalities, especially imaging, is rising. IoT imagers are often compact and have small form-factor batteries and thus must be designed with both low power (improving battery life) and high image quality (maximizing utility). Previously reported sensors [1, 2], along with this work, adopt motion-detection (MD) triggering of full-array capture where MD is performed on a heavily subsampled frame to enable continuous low-power operation. MD limits energy-hungry full-array captures to cases where activity is detected. To further reduce power consumption, the full-frame capture energy itself needs to be addressed, which is typically dominated by the ADC.
A constitutive expression system for glycosyl hydrolase family 7 cellobiohydrolases in Hypocrea jecorina (2015)

The elimination of background cellulase induction provides much more consistent measured specific activity compared to a traditional cbh1 promoter system induced with lactose. This expression system provides a powerful tool for the expression and comparison of mutant and/or phylogenetically diverse cellobiohydrolases in the industrially relevant cellulase production host H. jecorina.
Increased Airways Responsiveness in Mice Depends on Local Challenge with Antigen (1994)

In Balb/C mice, painting the skin with ovalbumin (OVA) over a period of 14 days resulted in sensitization of the animals. This was documented by the appearance of OVA-specific IgE and IgG1 antibodies and increased total serum IgE levels. In addition, in regional (inguinal) lymph nodes of sensitized animals, OVA-specific T cell proliferative responses and increased IgE and IgG production could be detected in vitro. Sensitized animals also developed immediate cutaneous responses to intradermal injection of OVA. In contrast to previous results following OVA sensitization via the airways, increased airways responsiveness to electrical field stimulation (AREFS) of tracheal smooth muscle preparations was not observed in skin-sensitized mice. Only 24 h after a single local challenge of the airways with aerosolized OVA on Day 14 could a significant increase in AREFS be observed in skin-sensitized but not nonsensitized control mice. These data indicate that sensitization of Balb/C mice to OVA via the skin provides an effective means for inducing a systemic IgE and IgG1 antibody response and immediate cutaneous hypersensitivity. Despite these IgE and IgG1-mediated responses, however, the development of altered function as reflected in an increase in AREFS was dependent on challenge with the allergen via the airways.
A star-shaped triphenylamine π-conjugated system with internal charge-transfer as donor material for hetero-junction solar cells (2006)

Introduction of dicyanovinyl groups on a triphenylamine-based conjugated system leads to an intramolecular charge transfer which extends the spectral response and raises the open-circuit voltage of the resulting hetero-junction solar cells.
Expanding the Repertoire of Modified Vaccinia Ankara-Based Vaccine Vectors via Genetic Complementation Strategies (2009)

Our identification of a spontaneously-immortalized (but not transformed) chicken embryo fibroblast cell line (DF-1) that is fully permissive for MVA growth and that can be engineered to stably express MVA genes provides the basis for a genetic system for MVA. DF-1 cells (and derivatives thereof) constitute viable alternatives, for the manufacture of MVA-based vaccines, to primary CEFs -- the conventional cell substrate for MVA vaccines that is not amenable to genetic complementation strategies due to these cells' finite lifespan in culture. The establishment of a genetic system for MVA, as illustrated here to allow udg deletion, enables the generation of novel replication-defective MVA mutants and expands the repertoire of genetic viral variants that can now be explored as improved vaccine vectors.
IDENTIFICATION OF n-STATE SPATIO-TEMPORAL DYNAMICAL SYSTEMS USING A POLYNOMIAL MODEL (2008)

A multivariable polynomial model is introduced to describe n-state spatio-temporal systems. Based on this model, a new neighborhood detection and transition rules determination method is proposed. Simulation results illustrate that the new method performs well even when the patterns are corrupted by static and dynamical noise.
DTM, DVS, optimal control (2003)

Modern out-of-order processors tolerate long-latency memory operations by supporting a large number of in-flight instructions. This is achieved in part through proper sizing of critical resources, such as register files or instruction queues. In light of the increasing gap between processor speed and memory latency, tolerating upcoming latencies in this way would require impractical sizes of such critical resources.To tackle this scalability problem, we make a case for resource-conscious out-of-order processors. We present quantitative evidence that critical resources are increasingly underutilized in these processors. We advocate that better use of such resources should be a priority in future research in processor architectures.
The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota (2009)

Background: Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides an opportunity for comparative analysis of the three genomes. Results: The 1.57 Mbp genome of the hyperthermophilic crenarchaeote Staphylothermus marinus has been completely sequenced. The main energy generating pathways likely involve 2-oxoacid: ferredoxin oxidoreductases and ADP-forming acetyl-CoA synthases. S. marinus possesses several enzymes not present in other crenarchaeotes including a sodium ion-translocating decarboxylase likely to be involved in amino acid degradation. S. marinus lacks sulfur-reducing enzymes present in the other two sulfur-reducing crenarchaeotes that have been - sequenced Thermofilum pendens and Hyperthermus butylicus. Instead it has three operons similar to the mbh and mbx operons of Pyrococcus furiosus, which may play a role in sulfur reduction and/or hydrogen production. The two marine organisms, S. marinus and H. butylicus, possess more sodium-dependent transporters than T. pendens and use symporters for potassium uptake while T. pendens uses an ATP-dependent potassium transporter. T. pendens has adapted to a nutrient-rich environment while H. butylicus is adapted to a nutrient-poor environment, and S. marinus lies between these two extremes. Conclusion: The three heterotrophic sulfur-reducing crenarchaeotes have adapted to their habitats, terrestrial vs. marine, via their transporter content, and they have also adapted to environments with differing levels of nutrients. Despite the fact that they all use sulfur as an electron acceptor, they are likely to have different pathways for sulfur reduction.
Wireless Sensor Network for Energy and Environmental Monitoring: Helping Old Buildings Go Green (2011)

Today, the rising cost of energy and social trend of “going green” has put increasing pressure on commercial property owners to improve the efficiency of their investments. There is good reason for this, too. In the State of California, office buildings represent the single largest user of energy in the commercial sector. This project consisted of the design, implementation, construction, testing, and deployment of a wireless sensor network for energy and environmental monitoring in retrofit commercial office installations. The analyzed data generated by this system can be used by building management and owners to identify areas of inefficiency within the building’s major energy using systems – namely heating, ventilation, and air conditioning (HVAC) and lighting. While suitable for use in new construction, the system was designed for ease-of-use in retrofit installations in existing construction. The final system consists of a self-expanding mesh network of lightweight, battery- and line-powered sensor nodes which are installed at various locations throughout the building to gather power consumption, environmental, occupancy, and space utilization data for a complete energy audit.
Orphon spliced-leader sequences form part of a repetitive element inAngiostrongylus cantonensis (1995)

In nematodes, the 22 nucleotide (nt) spliced leader (SL) is normally encoded by a multi-copy, tandemly reiterated SL gene and is trans-spliced from SL-RNA onto the 5' end of a subset of mRNAs. We have found that the SL is also encoded at multiple (> 100) orphon genomic sites in the parasitic nematode Angiostrongylus cantonensis. At these sites the sequence forms part of a 198 bp repetitive element (designated con-198). Transcription from two genomic elements that contain the con-198 sequence has been characterised. At one element (G-2) an approximately 850 nt RNA with an internal SL is transcribed. At the other (G-1), transcription takes place 3 kb downstream of the con-198 sequence.
The effect of Co(II)‐mediated catalytic chain transfer on the emulsion polymerization kinetics of methyl methacrylate (2009)

Abstract The effect the catalytic chain transfer agent, bis[(difluoroboryl) dimethylglyoximato] cobalt(II) (COBF), on the course of the ab initio emulsion polymerization of methyl methacrylate, and the product properties in terms of the molecular weight distribution were investigated. The emulsion polymerization kinetics have been studied with varying surfactant, initiator, and COBF concentrations. The experimentally determined average number of radicals per particle strongly depends on the concentration of COBF and proves to be in good agreement with the results of model calculations. The apparent chain transfer constant, determined up to high conversion, is in excellent agreement with the predicted value based on a mathematical model based on COBF partitioning and the Mayo equation. The results of this work enhance the fundamental understanding of the influence a catalytic chain transfer agent has on the course of the emulsion polymerization and the control of the molecular weight distribution. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5078–5089, 2009
Particle-BasedReconfigurable Scattering Masks forLensless Imaging (2020)

Light scattering
is typically undesired in optical systems as it
often introduces defects or otherwise negatively impacts device performance.
However, rather than being a hindrance, scattering can also be exploited
to achieve lensless imaging using a scattering mask instead of lenses
to enable devices with low-cost, compact construction, and yet a large
field of view. Lensless imaging can benefit greatly from the ability
to dynamically tune the scattering pattern produced by the mask; however,
this often results in increased complexity and cost. Herein, we propose
and demonstrate particle-based reconfigurable scattering masks to
dynamically tune light scattering for lensless imaging, enabling multishot
image reconstruction. Disordered particle populations are tuned by
rational application of electric fields without requiring bulky or
expensive components. Several assembly motifs are explored and studied
for optimal performance; in particular, gold nanowires chained between
planar electrodes yield the best reconstruction quality and are the
main focus in this study. The distinct gold nanowire based scattering
masks achieve a complex wavelet structural similarity as low as 0.36.
By leveraging the submicrometer thickness of particles and the resultant
large optical memory effect, an angular field of view of ±45°
is demonstrated. The reconfigurable nature of the particle arrays
enables multishot reconstruction which results in enhanced image quality
and improved signal-to-noise ratios by up to 10-fold. These results
suggest that reconfigurable particle masks could be a broadly applicable
means of achieving dynamically tunable light scattering with potential
applications in lensless microscopy or high-resolution imaging.
Encoding Knowledge of Commonsense Psychology (2005)

Abstract : In previous papers (Gordon and Hobbs, 2003, 2004) we have described a methodology for determining what knowledge should be included in the knowledge base for an intelligent agent, capable of constructing and executing plans to achieve its goals. An intelligent agent is at least a planning mechanism, so Gordon (2004) asked what concepts are necessary for the common strategies that people use in achieving their goals. He investigated ten different domains, including politics, personal relationships, artistic performance, and warfare, and collected 372 strategies. He authored representations of these strategies in order to identify a controlled vocabulary involving these concepts. These concepts were categorized into 48 different representational areas, such as sets, space, and time. Thirty of the representational areas, involving 635 concepts, were concerned with commonsense psychology; among these are memory, knowledge management, planning, and so on. This result by itself demonstrates the very great importance of commonsense psychology in the construction of intelligent agents. Gordon et al. (2003) then, to define further each of the representational areas, augmented the list of concepts by investigating the English language expressions for concepts in each area. The result was a list of 528 concepts, a set that identifies the target coverage of a formal theory of commonsense psychology. The authors began the development of formal theories that would encompass this list of concepts. In our earlier work (Gordon and Hobbs, 2003), we described the first theory we constructed, memory, as an illustration of the method. We have now completed 14 of the 30 theories, and this paper provides an overview of this work as we close in on the halfway mark.
Meeting Highlights: Adjuvant Therapy for Breast Cancer (1988)

Despite advances in early diagnosis and primary treatment of breast cancer with surgery, radiation therapy, or both modalities, more than one-third of newly diagnosed patients will develop recurrent or systemic disease and ultimately die. All these patients are potential candidates for some form of systemic adjuvant therapy involving the use of cytotoxic drugs and/or endocrine therapy after definitive local treatment The Third International Conference on Adjuvant Therapy of Primary Breast Cancer in St. Gallen, Switzerland, March 2-5, 1988, brought together experts from all over the world to present their most recent data and to discuss the remaining challenges that confront both clinicians and basic scientists.