gebhart/patrepeval huggingface dataset:
Chromatographically Fractionated Complementary Strands of Bacillus subtilis Deoxyribonucleic Acid: Biological Properties (1973)

Biological, physical, and chromatographic properties of methylated albuminkieselguhr (MAK)-fractionated complementary strands, designated as light (L) and heavy (H), of Bacillus subtilis deoxyribonucleic acid (DNA) are presented. The pattern of transforming activity along the MAK elution profile of alkilidenatured DNA shows that the residually active molecules selectively fractionated ahead of the L strand fraction, whereas the most active self-annealed molecules fractionated preferentially at the trailing end of the H strand fraction. The restoration rate of transforming activity in the late-eluting H molecules was rapid and independent of concentration during the annealing reaction. The data suggest that the self-annealing activity in the H strand is due in part to the formation of intrastrand secondary structures. Hydroxyapatite chromatography of self-annealed L and H strands yielded a major fraction (I) of highly purified strand preparations devoid of transforming activity and hypochromicity, and a minor "nativelike" fraction (II). Sedimentation velocity measurements show that, in addition to the mutual complementary nature of the L and H fractions, they differ in molecular size and possibly configuration.
Review article: Helicobacter pylori and gastro‐oesophageal reflux disease (2005)

Epidemiological studies demonstrate a negative association between Helicobacter pylori infection and gastro-oesophageal reflux disease and its complications. This might represent a protective effect because of the tendency for H. pylori infection to lower gastric acid secretion with advancing age. However, studies of the effect of H. pylori eradication on gastro-oesophageal reflux disease have failed to show any worsening of gastro-oesophageal reflux disease symptoms. Several interactions between H. pylori and proton-pump inhibitor therapy used to treat gastro-oesophageal reflux disease need to be considered. Helicobacter pylori infection improves the control of gastric acidity by proton-pump inhibitors and this produces a small advantage in clinical control of reflux disease. The infection prevents rebound acid hypersecretion occurring when proton-pump inhibitor therapy is discontinued. However, concerns have been expressed that the body gastritis induced by proton-pump inhibitor therapy in H. pylori-infected subjects might increase the risk of gastric cancer. At present, it is unclear whether H. pylori should be eradicated in gastro-oesophageal reflux disease patients.
Purification of Beryllium by Acetylacetone — EDTA Solvent Extraction: Procedure and Chemistry (1965)

A procedure, described previously, for the preparation of high purity beryllium hydroxide has been improved and demonstrated on a kilogram scale, and a systematic study of its chemistry has been carried out. The Be(OH)2·xH2O starting material is dissolved in acetylacetone (HX) as BeX2, scrubbed with aqueous EDTA to remove metallic impurities, stripped with nitric acid, and precipitated with ammonia. The dried Be(OH)2 · 0.3 H2O, a granular, free-flowing powder, was obtained in 85% yield. Detectable metallic impurities totalled <5 parts/106. The variation of BeX+ and BeX2 formation quotients with ionic strength as well as the variation of BeX2 and HX distribution coefficients with both aqueous ionic strength and organic phase composition are summarized. Decontamination efficiencies for some 13 cations were estimated to be very high. Effective purification was demonstrated on a sample of Be(OH)2 starting material which was contaminated with 1000 parts/106 parts BeO of Na+, Mg2+, B(III), Cu2+, Al3+, Fe3+ and Cr3+.
Rinçage pulsé et dispositif d’accès vasculaire (2010)

L’occlusion est la principale complication des acces vasculaires. Le rincage est souvent conseille pour desobstruer les catheters ou eviter les depots chimiques ou proteiques. Mais aucune technique de rincage n’est precisee. Le but de ce travail est de comparer experimentalement les differents rincages souvent utilises en clinique (perfusion continue, injection continue ou intermittente) et d’en verifier les effets. L’hydrodynamique est determinante dans ce cadre prophylactique : un flux intermittent peut mobiliser la majorite des depots intraluminaux et ainsi prevenir occlusion et infection.
Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations (2023)

While small differences were noticeable, they did not systematically emerge between Chinese and Western populations, but rather diffusively across all data sets. These findings suggest that DM presents similar properties, notwithstanding sociocultural backgrounds, and that it is equally effective in capturing the loss of homeostasis that occurs during aging in diverse industrial human populations.
C to U editing and modifications during the maturation of the mitochondrial tRNAASPin marsupials (1995)

In marsupial mitochondria, the nucleotide residue at the second position of the anticodon of the tRNA for aspartic acid is changed post-transcriptionally such that the translational machinery recognizes it as a uracil rather than the cytosine residue encoded in the gene. By postlabeling nucleotide analysis, we show here that the cytosine residue is converted to a conventional uracil residue in an RNA editing event that affects approximately half of the tRNA molecules under steady state conditions. Furthermore, we have identified three different tRNA(Asp) species which all carry three pseudouridines and two methylations but have the anticodons GCC, GUC and QUC respectively, the latter representing a rare example of queuine incorporation into a mitochondrial tRNA. This allows us to describe a likely sequential order of modification of the tRNA(Asp), where methylations and conversions of uridines to pseudouridines precede the editing event, while the exchange of guanine by queuine takes place after the C to U editing event.
[Determination of triptophenolide in Chinese herb leigongteng by TLCS]. (1999)

The method is proper for the quality control of Leigongteng.
Role of angiogenesis and angiogenic factors in acute and chronic wound healing (2015)

Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue. This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment. Vascular endothelial growth factor, angiopoietin, fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis. Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair. In particular integrin (v3) receptors for fibrin and fibronectin, appear to be required for wound angiogenesis: v3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot, and any functional inhibitors of v3 such as monoclonal antibodies, cyclic RGD peptide antagonists, and peptidomimetics rapidly inhibit granulation tissue formation. In spite of clear knowledge about influence of many angiogenic factors on wound healing, little progress has been made in defining the source of these factors, the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair.
Multiscale entropy to distinguish physiologic and synthetic RR time series (2003)

We address the challenge of distinguishing physiologic interbeat interval time series from those generated by synthetic algorithms via a newly developed multiscale entropy method. Traditional measures of time series complexity only quantify the degree of regularity on a single time scale. However, many physiologic variables, such as heart rate, fluctuate in a very complex manner and present correlations over multiple time scales. We have proposed a new method to calculate multiscale entropy from complex signals. In order to distinguish between physiologic and synthetic time series, we first applied the method to a learning set of RR time series derived from healthy subjects. We empirically established selected criteria characterizing the entropy dependence on scale factor for these datasets. We then applied this algorithm to the CinC 2002 test datasets. Using only the multiscale entropy method, we correctly classified 48 of 50 (96%) time series. In combination with Fourier spectral analysis, we correctly classified all time series.
Prognostische Wertigkeit disseminierter Tumorzellen im Knochenmark von Prostatakarzinompatienten. Veränderung unter endokriner Therapie? (2006)

Einleitung: Für verschiedenen Tumorentitäten (Mamma, Ösophagus, Colorectum) konnte der Nachweis disseminierter Tumorzellen (DTC) im Knochenmark (KM) als prognostisch relevant nachgewiesen werden. In der größten diesbezüglichen Untersuchung konnte dies von Weckermann et al auch für das Prostatakarzinom (PC) gezeigt werden. Unverändert stellt die Hormonablation die systemische Therapie der Wahl beim Prostatakarzinom dar. Aufgrund der damit verbundenen PSA Suppression ist jedoch insbesondere in der adjuvanten Situation eine posttherapeutische Risikoabschätzung der Patienten derzeit nicht möglich. Hier stellt die Untersuchung des KM Status möglicherweise eine interessante Alternative dar. Informationen zur prognostischen Wertigkeit DTC im KM nach endokriner Therapie liegen bislang jedoch nicht vor. Dieser Frage wird in der vorgelegten Untersuchung nachgegangen.
Simulation of the Transverse Fractures of the Sacrum Using a Finite Element Model of Lumbar Spine-Pelvis Segment (2008)

The sacrum fractures are very severe trauma which frequently accompanied with lumbar spine fractures. The surgical procedures often require primary stabilization of both lumbar spine and sacrum. To understand the rationale of the instrumentation numerous cadaveric studies were conducted to elucidate the anatomy of fractures and treatment options [1,2,3]. The modern computer technology allowed simulating the fractures and repairing using the Finite Element Analysis, also [4,5]. The last method has a raw of advantages versus cadaveric method such as higher reliability, accuracy, and safety. Finite element investigations of the pelvic fractures allowed comparing the influence of implants on pelvis stability. However, the extensive search of the literature failed to find a finite element model which includes the pelvis and lumbar spine together. Current study is the first step to accomplish this goal. An experimentally validated model of ligamentous lumbar spine was combined with the FE model of pelvis [7], and simulation of the sacrum fractures was conducted.
Mild Silver(I)-Mediated Regioselective Iodination and Bromination of Arylboronic Acids (2010)

A convenient and regioselective silver(I)-mediated electrophilic iodination and bromination reaction of arylboronic acids has been developed. The boronic acid does not require protection prior to the reaction, which can be performed on a multigram scale with moderate to excellent yields. A mild, simple, and effective method is disclosed to provide ortho-haloarylboronic acids that can be used as useful intermediates in selective sequential Suzuki-Miyaura cross-coupling reactions to provide ortho-triaryl derivatives in good yields.
Data-Driven Forecasting of Postflutter Responses of Geometrically Nonlinear Wings (2020)

Ensuring adequate flutter margins is a critical step in aircraft design. However, in the presence of nonlinear effects, subcritical limit-cycle oscillations can arise even before flutter occurs. When nonlinear effects are anticipated, postflutter analyses have to be integrated into aircraft design in addition to flutter computations for preventing this undesirable subcritical behavior. Therefore, there is a need for computationally fast postflutter analysis methods suitable for design applications. This paper investigates a data-driven method to forecast the bifurcation behavior of a geometrically nonlinear wing, demonstrating its suitability to analyze realistic nonlinear aeroelastic systems. The method efficiently forecasts postflutter responses using only a few system transient computations in the preflutter regime. First, the accuracy of forecasted bifurcation diagrams is verified against time-marching results. Next, wing design parameters are varied to investigate their impact on postflutter responses and show the method suitability to parametric studies.
The RNA Binding Domain of Influenza A Virus NS1 Protein Affects Secretion of Tumor Necrosis Factor Alpha, Interleukin-6, and Interferon in Primary Murine Tracheal Epithelial Cells (2007)

Primary differentiated respiratory epithelial cell cultures closely model the in vivo environment and allow for studies of innate immune responses generated specifically by epithelial cells, the primary cell type infected by human influenza A virus strains. We used primary murine tracheal epithelial cell (mTEC) cultures to investigate antiviral and cytokine responses to influenza A virus infection, focusing on the contribution of the RNA binding domain of the NS1 protein. rWSN NS1 R38A replication is attenuated in mTEC cultures; however, viral antigen is detected predominantly in ciliated cells, similar to wild-type virus. NS1 and NS1 R38A proteins display a primarily cytoplasmic localization in infected mTEC cultures. Increased production of tumor necrosis factor alpha, interleukin-6, and beta interferon is observed during rWSN NS1 R38A infection, and cytokines are secreted in a directional manner. Cytokine pretreatment of mTEC cultures and Vero cells suggest that rWSN NS1 R38A is more sensitive to the presence of antiviral/inflammatory cytokines than wild-type virus. Our results demonstrate that the RNA binding domain is a critical regulator of both cytokine production and cytokine sensitivity during influenza A virus infection of primary tracheal epithelial cells.
The influence of dietary intake on the serum lipid profile, body mass index and risk of cardiovascular diseases in adults on the Niger Delta region (2010)

This study is designed to assess some of the risk factors for cardiovascular diseases (CVD) in healthy adult subjects in the Niger Delta region of Nigeria, in relation to their dietary intake habits. 131 male and female adults aged 20 - 40 years were assessed. Anthropometric measurements, blood pressure, serum lipid profile and electrolytes among two populations were estimated. Diet history recall questionnaire, food sample analysis and food composition tables were used to compute energy and nutrients intake. In Delta State subjects, the body mass index (BMI) was significantly different from those of Cross River State. There was a significantly higher intake in energy and protein and a lower fibre and ash intake by the participants from Delta State. Total serum cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triacylglycerides (TG) and TC/HDL-C ratio, were also higher in Delta State participants. In conclusion, we inferred that 22, 15 and 35% of the participants from Delta State were at risk of CVD compared to 5, 6 and 10% from Cross River based on the respective BMI, blood pressure and TC/HDL-C ratio values.

	 

	 Key words: Body mass index, cardiovascular diseases, dietary intakes, serum lipids.
Design of a Security Management Middleware in Ubiquitous Computing Environments (2005)

In this paper, we propose a security management middleware in ubiquitous computing environments. This security management should be applicationoriented security and provides user-centric security. This middleware provides the services for user or administrator to define security policies which can reflect dynamic context and trust management. We define a new security specification policy language for policy management. It also provides management services which can monitor and control the managed objects and sensors for the domain security management.
Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue (2017)

In highly organized tissues, such as cartilage, tendons and white matter, several quantitative MRI parameters exhibit dependence on the orientation of the tissue constituents with respect to the main imaging magnetic field (B<sub>0</sub>). In this study, we investigated the dependence of multiple relaxation parameters on the orientation of articular cartilage specimens in the B<sub>0</sub>. Bovine patellar cartilage-bone samples (n = 4) were investigated ex vivo at 9.4 Tesla at seven different orientations, and the MRI results were compared with polarized light microscopy findings on specimen structure. Dependences of T<sub>2</sub> and continuous wave (CW)-T<sub>1ρ</sub> relaxation times on cartilage orientation were confirmed. T<sub>2</sub> (and T<sub>2</sub>*) had the highest sensitivity to orientation, followed by T<sub>RAFF2</sub> and adiabatic T<sub>2ρ</sub>. The highest dependence was seen in the highly organized deep cartilage and the smallest in the least organized transitional layer. Increasing spin-lock amplitude decreased the orientation dependence of CW-T<sub>1ρ</sub>. T<sub>1</sub> was found practically orientation-independent and was closely followed by adiabatic T<sub>1ρ</sub>. The results suggest that T<sub>1</sub> and adiabatic T<sub>1ρ</sub> should be preferred for orientation-independent quantitative assessment of organized tissues such as articular cartilage. On the other hand, based on the literature, parameters with higher orientation anisotropy appear to be more sensitive to degenerative changes in cartilage.
Beamline optimization for 100keV diagnostic neutral beam (DNB) injector for ITER (2009)

The 100 kV negative hydrogen ion source based Diagnostic Neutral Beam (DNB) injector, which forms a part of the IN Procurement Package for ITER, targets a delivery of ~18-20A of neutral hydrogen atom beam current into the ITER torus for charge exchange resonance spectroscopy (CXRS) diagnostics. Considering stripping losses, ~70A negative ion current is required to be extracted from the ion source, which leads to a production of 60 A of accelerated ion beam. Subsequent process of neutralization, electrostatic ion separation and transport to the duct leads to a large separation between the points of generation of ion beam to the point of delivery of the neutral beam into the Torus (~23 m). This forms one of the most important constraints for the transport of neutral beams to ITER. The requirements are not only for a stringent control over ion optics, the transport to electrostatic separator, minimum loss of beam due to intercepting elements, low reionization loss, focusing to control interception losses, adequate compensation of residual magnetic fields to overcome magnetic field induced deflections also forms important design issues for a reasonable transmission efficiency. Due to the multi parameter dependence, it becomes necessary to assess different scenarios using numerical codes. In the present case the assessment has been carried out for the DNB using the beam transport codes PDP, BTR and the MCGF codes which are developed by the Russian Federation. An optimized configuration of the beam line has been arrived at on the basis of these codes enabled studies. These parameters are: listing of the vertical and horizontal focal lengths as 20.6 m, a spacing between ground grid and neutralizer of 1 m, positioning of RID at a distance of 0.75 m from the neutraliser exit. Further, optimizing the gas feed to the source and neutralizer lead to a final transmission of ~35% of the extracted beam power to the torus. The paper shall present the methodology, the issues concerned and the final configuration which forms the basis for the present engineering.
A Guide to Thin-Layer Chromatographic Systems for the Separation of Aflatoxin B1, B2, G1and G2 (1981)

Abstract The separation of aflatoxin B1, B2, G1 and G2 was compared on six commercial silica gel plates in twelve solvent systems. Two of the solvent systems, chloroform: acetone: ammonium hydroxide (90: 10: 0.25) and chloroform: acetone: hexane (85: 15: 20) resolved the four aflatoxins on all the tested plates. The solvent modifier played an important role in the resolution of these compounds. The effect of the hardness of the plate is also discussed.
Wafer integrated bubble memory chip (1979)

A wafer level integration method is proposed for building large capacity bubble memory chips using present processing technology. A single cell pattern is stepped and repeated to generate a matrix of cells. Each cell has basically a major-minor structure. With exchange switch pairs and geometry tolerant junction elements, the bubbles can be transferred between major loops of the adjacent cells in the same row or column. The control functions of those cells in the same row are also interconnected to the edge of the wafer, and thus can share the same driver electronics. These cells are integrated magnetically and electrically. They can share one or a few I/O ports and effectively form a large capacity chip. Since all the cells are identical, the final chip size can be any combination of the cells. A yield model study is performed to show the relationship between chip size and yield.
Dihydroxyacetone Reductase Responsible for Less-aerobic Growth of a Methylotrophic Yeast,Hansenula ofunaensis (1988)

Correlation between the activity of dihydroxyacetone reductase (DHAR) and the intracellular content of glycerol in a methylotrophic yeast, Hansenula ofunaensis, was observed when it was grown on methanol. The DHAR activity and the glycerol synthesis were low in the presence of a high concentration of NaCl or KC1. DHAR activity increased with growth under less-aerobic conditions in the methanol medium. The less-aerobic conditions after aerobic cultivation increased the glycerol synthesis. Methanol was the most effective carbon source for DHAR synthesis and glycerol did not repress the synthesis. From these results, it was concluded that DHAR in methanol-grown cells of H. ofunaensis might be responsible for the growth under less-aerobic conditions, but not for that under salt stress conditions or for glycerol synthesis itself.
Utility of the Diamond-Forrester Classification in Stratifying Acute Chest Pain in an Academic Chest Pain Center (2016)

In a contemporary low-risk acute chest pain population, typical angina, as defined by the DF classification, was not predictive of CAD or useful for identifying patients with higher symptom burden.
Plan B and the Politics of Doubt (2006)

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