gebhart/patrepeval huggingface dataset:
Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function (1995)

Conference Article| August 01 1995 Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function M. Bouvier; M. Bouvier * *To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar T. P. Loisel; T. P. Loisel 1Département de Biochimie, Faculté de Médecine, Université de Montréal, Montréal, Qc, P.O. Box 6128, Succursale Centre-Ville, Canada H3C 3J7 Search for other works by this author on: This Site PubMed Google Scholar T. Hebert T. Hebert 1Département de Biochimie, Faculté de Médecine, Université de Montréal, Montréal, Qc, P.O. Box 6128, Succursale Centre-Ville, Canada H3C 3J7 Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: March 08 1995 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1995 Biochemical Society1995 Biochem Soc Trans (1995) 23 (3): 577–581. https://doi.org/10.1042/bst0230577 Article history Received: March 08 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation M. Bouvier, T. P. Loisel, T. Hebert; Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function. Biochem Soc Trans 1 August 1995; 23 (3): 577–581. doi: https://doi.org/10.1042/bst0230577 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: AR, adrenergic receptor, LH, luteinizing hormone, hGC, human chorionic gonadotropin, PKA, cyclic-AMP-dependent protein kinase This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Planning for variable generation integration through balancing authorities consolidation (2012)

As more and more variable generation is integrated into power grids, many challenges and concerns arise for an individual balancing authority (BA) to balance the system with limited flexible generation resources. Consolidating balancing authorities provides a promising method to mitigate these problems by enabling the sharing of balancing resources through operating different BAs as a single BA. The diversity in load and renewable generation over a wide area can be effectively used, which makes it possible to achieve significant savings in balancing requirements. This paper develops a detailed procedure to compute savings in load following and regulation service requirements due to BAs consolidation. It proposes several evaluation metrics for demonstrating the benefits of BA consolidation. Several study scenarios are designed for a set of BAs in the western United States to test the proposed procedure. Results have shown significant savings in the capacity, ramp rate, and energy of balancing service requirements. Important factors affecting the savings, such as forecast accuracy and cross correlation between forecast errors, are also discussed.
INACTIVATION OF CLOSTRIDIUM BOTULINUM TYPE E SPORES BY HIGH PRESSURE PROCESSING (1999)

ABSTRACT The effect of high pressure treatments at various temperature combinations on the inactivation of Clostridium botulinum type E spores of strains, Alaska and Beluga in phosphate buffer (0.067 M, pH 7.0) was investigated. No reduction of spores was observed at any pressurization (Maximum = 827 MPa) for temperatures below 35C. At pressurization of 827 MPa for 5 min, log unit reduction of spores increased as temperatures increased from 35 to 55C. An increase in the processing time from 5 to 10 min at a combination of high pressure (827 MPa) and low temperature (40C) resulted in a 5‐log reduction of Alaska spores. About 5‐log reductions for strains Alaska and Beluga occurred at 50 and 55C, respectively, after processing at pressures of 827 MPa for 5 min.
0140 Genetic and environmental components of disease traits in dairy cattle (2016)

Diseases in U.S. Holstein are responsible for losses of approximately $ 1 billion annually in dairy production due to reduced milk production and increased costs. The objective was to assess the impact of environmental factors and magnitude of genetic parameters on the incidence of diseases in dairy cows early (<10 d) and late (35 to 60 d) postpartum. Binary and multinomial disease records on approximately 6000 Holstein cows from farms in Texas, Minnesota, California, and Florida were evaluated using mixed effects logistic and Poisson models. Early postpartum binary diseases included: dystocia, retained placenta, subclinical ketosis (blood β-hydroxybutyrate BHBA > 1), and metritis. Late postpartum binary diseases included: displacement of abomasum, mastitis, respiratory problems, and clinical endometritis. Mucus score at 7 d, number of mastitis cases up to 60 d, and lameness at 35 d (five levels) were analyzed assuming a Poisson model. Fixed effects in all models included: lactation number (3 levels), season (summer and winter), U.S. region, and farm. Other fixed effects evaluated depending on the disease included: twins, body condition score, BHBA level, calf gender, stillbirth, first test-day milk production record, and other diseases. The cow's sire was included as a random effect in the models. Overall lactation, region, and season had a significant effect on the incidence of all diseases, except for lactation on respiratory problems, and season on mastitis and displacement of abomasum. First lactation cows exhibited the highest incidence of dystocia, metritis, and clinical endometritis and lowest incidence of mastitis, retained placenta, lameness, and displacement of abomasum. Clinical endometritis, metritis, lameness, and respiratory problems were lower in summer than winter. Dystocia, retained placenta, and subclinical ketosis were positively and significantly associated with clinical endometritis and metritis. Subclinical ketosis and dystocia were positively and significantly associated with displacement of abomasum. Mastitis was negatively and significantly associated with milk yield at first test-day. Heritability estimates for the diseases ranged from 0.06 (retained placenta) to 0.4 (respiratory problems). The differences in genetic parameter estimates among alternative disease descriptors offer insights into effective approaches to lower the incidence of disease through genetic selection. These findings contribute to a long-term multistate project database (USDA-NIFA-AFRI-003542) for direct measures of fertility.
Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease (S1.001) (2017)

To determine whether an aggregate burden of variants in lysosomal storage disorder (LSD) genes besides GBA are associated with Parkinson’s disease (PD) susceptibility.
Critical amino acid residues involved in the electrogenic sodium–bicarbonate cotransporter kNBC1‐mediated transport (2005)

We have previously reported a topological model of the electrogenic Na(+)-HCO(3)(-) cotransporter (NBC1) in which the cotransporter spans the plasma membrane 10 times with N- and C-termini localized intracellularly. An analysis of conserved amino acid residues among members of the SLC4 superfamily in both the transmembrane segments (TMs) and intracellular/extracellular loops (ILs/ELs) provided the basis for the mutagenesis approach taken in the present study to determine amino acids involved in NBC1-mediated ion transport. Using large-scale mutagenesis, acidic and basic amino acids putatively involved in ion transport mediated by the predominant variant of NBC1 expressed in the kidney (kNBC1) were mutated to neutral and/or oppositely charged amino acids. All mutant kNBC1 cotransporters were expressed in HEK-293T cells and the Na(+)-dependent base flux of the mutants was determined using intracellular pH measurements with 2',7'-bis-(carboxyethyl)-5(6)-carboxyfluorescein (BCECF). Critical glutamate, aspartate, lysine, arginine and histidine residues in ILs/ELs and TMs were detected that were essential for kNBC1-mediated Na(+)-dependent base transport. In addition, critical phenylalanine, serine, tyrosine, threonine and alanine residues in TMs and ILs/ELs were detected. Furthermore, several amino acid residues in ILs/ELs and TMs were shown to be essential for membrane targeting. The data demonstrate asymmetry of distribution of kNBC1 charged amino acids involved in ion recognition in putative outward-facing and inward-facing conformations. A model summarizing key amino acid residues involved in kNBC1-mediated ion transport is presented.
Biological Applications of Total Internal Reflection Fluorescence (2018)

Total internal reflection fluorescence (TIRF) is an optical technique especially well suited to the study of macromolecule/surface interactions. In particular, TIRF can be used to continuously monitor fluorescent macromolecules either close to (within about 2000 A or less) or directly adsorbed to a solid surface. This chapter provides a brief overview of some selected examples of recent applications of TIRF to the study of protein adsorption to solid surfaces. It begins with a brief overview of theoretical aspects related to TIRF. Factors recognized to be fundamentally relevant to protein/ surface interactions include adsorption, desorption, and diffusion kinetics, chemical equilibrium between surface-adsorbed proteins and free solution proteins, effects of the hydrodynamic environment on the adsorption process, and the conformation of the adsorbed protein layer. TIRF studies of protein adsorption can be divided into two categories: the quantitative investigation of kinetic, diffusion, and equilibrium characteristics; and the investigation of adsorbed protein conformation.
Application of POSS Compounds for Modification of the Wetting Properties of TISS Paint Coatings (2012)

This chapter contains sections titled: Introduction Wetting of Surfaces POSS Nanocomposites as Low Surface Energy Additives for Coatings Anti-wetting Properties of Coatings with Smooth Surfaces – Lacquers for Polymeric Glazing Anti-wetting Properties of Coatings on Rough Surfaces – TISS Paint Coatings Conclusions References
Toll‐like receptors: key activators of leucocytes and regulator of haematopoiesis (2007)

Toll-like receptors (TLRs) play a critical role in the induction of the immune response to invading pathogens. The detection of pathogens by TLRs initiates a signalling cascade that results in the activation of transcription factors such as nuclear factor (NF)-kappaB and interferon regulatory factors leading to the production of pro-inflammatory cytokines and type 1 interferons. Five cytoplasmic adaptors, MyD88, Mal, Trif, TRAM and SARM, are utilized by the TLRs to activate these signalling pathways. Through the years the main focus of research has been on the activation and function of TLRs in monocytic cells. This review discusses several additional roles of TLRs. TLR activation plays a role in influencing the differentiation of haematopoietic stem cells. Their activation also prevents apoptosis in neutrophils following pathogen invasion. B cells and T cells proliferation and differentiation is influenced by TLR activation and the possible therapeutic benefits of using TLR ligands for the treatment of chronic lymphocytic leukaemia will also be discussed.
Gas bubble size estimation in peat soils from EM wave scattering observed with ground penetrating radar (2017)

Abstract The size of biogenic gas bubbles in peatlands is believed to regulate ebullition of carbon gases to the atmosphere. The measurement of electromagnetic (EM) wave travel times using ground penetrating radar (GPR) is a proven field‐scale method for indirect estimation of volumetric gas content. However, there is also the possibility that information on the size of the gas bubbles can be determined from the analysis of the spectral content of GPR signals as scattering attenuation possesses a frequency dependence for bubbles smaller than the EM wavelength (Rayleigh‐type scattering). Theoretical modeling shows that GPR data acquired with typical antenna frequencies are likely to be affected by bubble size in peat soils. Analysis of GPR data from two recent studies on peat monoliths where biogenic gas production was documented produced results consistent with the model predictions. Using the approach, zero offset cross‐borehole GPR data in a northern peatland suggest that large bubble clusters (i.e., 0.05 m radius) occur in peat. These findings broaden the utility of GPR for providing information on biogenic gas dynamics in peatlands.
Evaluation of Absolute Number Densities by Diode Laser Atomic Absorption Spectroscopy (1991)

A simple method of evaluating absolute number densities in atom reservoirs is described. It consists of measuring the difference in the integrated absorption signals obtained from a reference cell and an analytical cell with a frequency-modulated diode laser as primary source. The evaluation of the number density of atoms in the analytical cell is straightforward and, in optically thin conditions both in the vapor cell and in th analytical cell, does not even require the knowledge of the absorption oscillator strength of the transition. Conversely, for a given, known value of the atomic density, the number density in the analytical cell can be obtained.
Isotopic signature and nano-texture of cesium-rich micro-particles: Release of uranium and fission products from the Fukushima Daiichi Nuclear Power Plant (2017)

Highly radioactive cesium-rich microparticles (CsMPs) released from the Fukushima Daiichi Nuclear Power Plant (FDNPP) provide nano-scale chemical fingerprints of the 2011 tragedy. U, Cs, Ba, Rb, K, and Ca isotopic ratios were determined on three CsMPs (3.79-780 Bq) collected within ~10 km from the FDNPP to determine the CsMPs' origin and mechanism of formation. Apart from crystalline Fe-pollucite, CsFeSi<sub>2</sub>O<sub>6</sub> · nH<sub>2</sub>O, CsMPs are comprised mainly of Zn-Fe-oxide nanoparticles in a SiO<sub>2</sub> glass matrix (up to ~30 wt% of Cs and ~1 wt% of U mainly associated with Zn-Fe-oxide). The <sup>235</sup>U/<sup>238</sup>U values in two CsMPs: 0.030 (±0.005) and 0.029 (±0.003), are consistent with that of enriched nuclear fuel. The values are higher than the average burnup estimated by the ORIGEN code and lower than non-irradiated fuel, suggesting non-uniform volatilization of U from melted fuels with different levels of burnup, followed by sorption onto Zn-Fe-oxides. The nano-scale texture and isotopic analyses provide a partial record of the chemical reactions that occurred in the fuel during meltdown. Also, the CsMPs were an important medium of transport for the released radionuclides in a respirable form.
Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6 (2011)

Our current study establishes the existence of a unique and significant population of basal progenitor cells in the thalamus and their dependence on neurogenins and Pax6. These progenitor cells may have important roles in enhancing the generation of neurons within the thalamus and may also be critical for generating neuronal diversity in this complex brain region.
Dynamic Reconfiguration of Agent-Based Applications (1999)

This paper examines the problem of dynamic application reconfiguration. We show that the addition of event-driven agents to an application built from interconnected components greatly improves the ability to reconfigure the application while in operation, for customization or added functionalities. Our preliminary experience is based on a specific architecture of interconnected components and agents, used for several distributed applications, including a firewall system. 1 Introduction In recent years, the software engineering community has devoted many efforts to the development of techniques and tools to support the design and implementation of applications to be distributed across networks and workstations. Some of this focus has been on support for initial development and configuration of applications while other research has focused on techniques to support these types of applications at runtime. We are currently conducting research intended to develop techniques for supporting...
Effect of additives on fat uptake and sensory quality of deep fried foods (2008)

Purpose The purpose of this paper is to investigate the effect of incorporation of selected additives on fat uptake and sensory quality of two traditional deep fried snacks. Design/methodology/approach A wheat‐based snack Diamond cuts , and a rice and gram‐based spicy snack Kodbale , were chosen. The products were prepared by incorporating to the dough, 0.2, 0.5, 0.75 and 1.0 per cent of 11 different additives like gum acacia, gum Tragacanth, Methylcellulose, Gaur Gum, Pectin, Gum Karaya, Gum Carageenan, Xanthan Gum, Gum Gellan, Seafoam and Beligara . Products were evaluated for sensory attributes and fat uptake was estimated by soxhlet extraction. Findings Results indicated that average fat uptake in Diamond cuts and Kodbale was 28.00 and 30 per cent, respectively. In Diamond cuts , while addition of additives did not alter fat uptake remarkably, a slight decrease in the case of gum Tragacanth (0.2 per cent) and Gaur Gum and Gum Carageenan (0.75 per cent) was observed. Statistical analysis of sensory attributes revealed only a marginal difference in textural quality of Diamond cuts incorporated with Gaur Gum, Pectin and Beligara . In Kodbale , fat uptake was marginally lowered by the addition of Gaur Gum, gum Tragacanth, Xanthan Gum and Gum Carageenan at 0.75 per cent. No significant differences were observed among the sensory qualities except for marginal differences in textural quality of Kodbale incorporated with Gaur Gum, Gum Carageenan and Beligara. It can be concluded that addition of additives did not influence the fat uptake or sensory quality of fried products studied to a significant extent. Originality/value Since some of the additives improved textural quality of products and fried products are usually stored and consumed, these additives can probably help in improving the texture of stored products. Further studies in this area would help in confirming this.
Pre-Lithiation Strategies for Rechargeable Energy Storage Technologies: Concepts, Promises and Challenges (2018)

In order to meet the sophisticated demands for large-scale applications such as electro-mobility, next generation energy storage technologies require advanced electrode active materials with enhanced gravimetric and volumetric capacities to achieve increased gravimetric energy and volumetric energy densities. However, most of these materials suffer from high 1st cycle active lithium losses, e.g., caused by solid electrolyte interphase (SEI) formation, which in turn hinder their broad commercial use so far. In general, the loss of active lithium permanently decreases the available energy by the consumption of lithium from the positive electrode material. Pre-lithiation is considered as a highly appealing technique to compensate for active lithium losses and, therefore, to increase the practical energy density. Various pre-lithiation techniques have been evaluated so far, including electrochemical and chemical pre-lithiation, pre-lithiation with the help of additives or the pre-lithiation by direct contact to lithium metal. In this review article, we will give a comprehensive overview about the various concepts for pre lithiation and controversially discuss their advantages and challenges. Furthermore, we will critically discuss possible effects on the cell performance and stability and assess the techniques with regard to their possible commercial exploration.
Comparison of radiographic parameters for analysis of normal and dysplastic hips in the adult. (1990)

Radiographic quantitation of the dysplastic hip in adults is difficult. This study compares the values for commonly used indices, the acetabular angle (AA), the center edge angle (CEA), and femoral head coverage, and the X-Y coordinate system on the anteroposterior pelvic radiograph in 30 adult patients with 60 normal hips, and 20 adult patients with 27 dysplastic hips. Dysplastic hips demonstrated significantly higher values for the AA and the X-Y coordinates, and significantly lower values for the CEA and femoral head coverage compared to normal hips. Femoral head coverage in dysplastic hips correlated best (negatively) with the Y coordinate, i.e., poorer coverage was associated with greater superior migration of the femoral head. The AA describes the slope of the acetabular roof, but does not take into account the relative position of the femoral head. The CEA measures the position of the femoral head in relation to the lateral lip of the acetabulum, but does not necessarily use the true acetabulum. The X-Y coordinate system relates the center of the femoral head to an identifiable acetabular landmark, the teardrop shadow. These coordinates are easily determined and can serve as an adjunct to other radiographic indices that quantitate the amount of subluxation in dysplastic hips in adults.
Assistance-On-Demand (2016)

We evaluated a system to support the driver in urban intersections (called "Assistance on Demand" AoD system). The system is controlled via speech and supports the driver in monitoring and decision making by providing recommendations for suitable time gaps to enter the intersection. This speech-based control of the system allows the implementation of an "on-demand"-concept where the driver can activate the assistance only if he desires support. 24 drivers took part in the study, performing three drives each. A comparison with a manual condition without system support showed that the AoD system was highly accepted, decreased workload and facilitated monitoring of traffic. In addition, subjective acceptance highly correlated with objective acceptance measured by the actual usage of the system. This clearly justifies the "on-demand"-concept.
Exocytosis and protein secretion in Trypanosoma (2010)

This study brings out several unexpected features of the secreted proteins and opens novel perspectives concerning the survival strategy of Trypanosoma as well as possible ways to control the disease. In addition, concordant lines of evidence support the original hypothesis of the involvement of microvesicle-like bodies in the survival strategy allowing Trypanosoma to exchange proteins at least between parasites and/or to manipulate the host immune system.
Effects of Different Mill Types on Ethanol Production Using Uncooked Dry‐Grind Fermentation and Characteristics of Residual Starch in Distiller's Dried Grains (DDG) (2017)

This study aimed to investigate impacts of milling methods on ethanol production using an uncooked dry‐grind (cold fermentation) process and characterize residual starch in the distiller's dried grains (DDG) coproduct. Four corn lines with different chemical compositions were ground with cyclone, ultra‐centrifugal, or hammer mills equipped with a screen of 0.5 mm opening and used for the cold fermentation process. Greater starch hydrolysis and ethanol yield were obtained from cyclone‐milled corn, resulting from larger damaged starch contents and smaller particle sizes of the ground corn. Corn grains and ground corn after five‐month storage showed less starch hydrolysis than the freshly ground counterpart. Residual starch (2.8–8.0%) with large proportions of intact amylopectin contents (up to 42.5%) was found in the DDG from all types of milling. The results suggested that the entrapment of starch granules in ground corn and a low activity of amylolytic enzymes at a high ethanol concentration were accountable for the remaining of starch in the DDG.