gebhart/patrepeval huggingface dataset:
Estudo experimental da eficácia clínica e microbiológica da associação do diclofenaco sódico e sulfato de gentamicina no tratamento da ceratite por Pseudomonas aeruginosa (1997)

RESUMO Objetivo: Comparar o efeito da associação de diclofenaco sódico 0,1%, mais sulfato de gentamicina 0,3% em olhos de coelhos infectados por meio de injeção intra-estromal de Pseudomonas aeruginosa, após remoção do epitélio da região central da córnea. Métodos: Os animais foram tratados com soluções tópicas contendo diferentes drogas. Grupo I: Associação de diclofenaco sódico 0,1%, mais sulfato de gentamicina 0,3%. Grupo II: Veículo da associação de diclofenaco sódico 0,1%, mais sulfato de gentamicina 0,3%. Grupo III: Apenas diclofenaco sódico 0,1%. Grupo IV: Sulfato de gentamicina 0,3% isoladamente. Grupo V: BSS. Grupo VI: Não recebeu nenhuma medicação. Os animais do grupo VI foram sacrificados no primeiro dia do experimento para verificar o comportamento da infecção corneal. Nos demais grupos as drogas foram usadas de uma em uma hora, no primeiro dia e sete vezes ao dia, nos seis dias restantes. A colheita de espécimes da conjuntiva foi feita 24 horas antes de se provocar a infecção, no primeiro, terceiro e oitavo dias do experimento. Após os animais terem sido sacrifícados as córneas foram removidas para contagem do número de bactérias remanescentes. Resultados: O número de coelhos com descemetocele, no terceiro dia do experimento, foi signifícantemente maior nos grupos tratados com BSS e apenas diclofenaco. Não houve diferença significante, quanto ao número de colônias isoladas da conjuntiva e córnea, nas diferentes fases do experimento. Conclusão: Diclofenaco sódico 0,1% não afetou a atividade antibacteriana do sulfato de gentamicina 0,3% no tratamento da ceratite experimental, por Pseudomonas aeruginosa, quando comparado com o uso apenas do sulfato de gentamicina 0,3%.
A strategic review of MXenes as emergent building blocks for future two-dimensional materials: recent progress and perspectives (2022)

The breathtaking success of MXenes arising from a library of unique and fascinating properties has triggered world-wide research interest and opened up several new directions in understanding the science and technology of two-dimensional materials.
Effects of expression Fli1 transcription factor on lupus disease development in NZM2410 mice (99.35) (2009)

Abstract The Fli1 gene is a member of the ets family of transcription factors that is expressed in hematopoietic cells. Two-fold overexpression of Fli1 protein in transgenic mice results in the development of a lupus-like disease. Expression of Fli1 in systemic lupus erythematosus (SLE) patients and animal models of lupus is higher compared to normal controls. Here we examined the effects of reduced Fli1 expression on disease development in NZM2410 mice, an animal model of SLE. We generated Fli1 knockout heterozygous mice (Fli1+/-; Fli-1 homozygous knockout is embryonic lethal). Compared to wild-type (Fli1+/+) mice, we found that expression of Fli1 protein in Fli1+/- mice was reduced by half. Autoantibodies, Urinary albumin excretion and serum immunoglobulin concentrations were measured by ELISA. Fli1+/- NZM2410 mice survived significantly longer than Fli1+/+ NZM2410 mice. At the age of 52 weeks, 81% Fli1+/- NZM 2410 mice survived, whereas only 35% of Fli1+/+ mice survived. There were significant low urinary albumin excretions in Fli1+/- NZM2410 mice compared to Fli1+/+ NZM2410 mice at the age of 34 weeks. Compared with Fli1+/+ NZM2410 mice, Fli1+/- NZM2410 mice have significantly decreased levels of IgG anti-dsDNA and glomerular antigen (GA) antibodies at the age of 34 weeks. Our results suggest that the expression of Fli1 plays an important role in disease development in NZM2410 mice.
Allosteric Modulation of the Adenosine Family of Receptors (2005)

Allosteric modulators for adenosine receptors (ARs) are of an increasing interest and may have potential therapeutic advantage over orthosteric ligands. Benzoylthiophene derivatives (including PD 81,723), 2-aminothiazolium salts, and related allosteric modulators of the A(1) AR have been studied. The benzoylthiophene derivatives were demonstrated to be selective enhancers for the A(1) AR, with little or no effect on other subtypes of ARs. Allosteric modulation of the A(2A) AR has also been reported. A(3) allosteric enhancers may be predicted to be useful against ischemic conditions. We have recently characterized two classes of A(3) AR allosteric modulators: 3-(2-pyridinyl)isoquinolines (e.g. VUF5455) and 1H-imidazo-[4,5-c]quinolin-4-amines (e.g. DU124183), which selectively decreased the agonist dissociation rate at the human A(3)AR but not at A(1) and A(2A) ARs. DU124183 left-shifted the agonist conc.-response curve for inhibition of forskolin-stimulated cAMP accumulation in intact cells expressing the human A(3)AR with up to 30% potentiation of the maximal efficacy. The increased potency of A(3) agonists was evident only in the presence of an A(3) antagonist, since VUF5455 and DU124183 also antagonized, i.e. displaced binding at the orthosteric site, with K(i) values of 1.68 and 0.82 microM, respectively. A(3)AR mutagenesis studies implicated F182(5.43) and N274(7.45) in the action of the enhancers and was interpreted using a rhodopsin-based A(3)AR molecular model, suggesting multiple binding modes. Amiloride analogues, SCH-202676 (N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine), and sodium ions were demonstrated to be common allosteric modulators for at least three subtypes (A(1), A(2A), and A(3)) of ARs.
Transparent functional oxide stretchable electronics: micro-tectonics enabled high strain electrodes (2013)

Fully transparent and flexible electronic substrates that incorporate functional materials are the precursors to realising next-generation devices with sensing, self-powering and portable functionalities. Here, we demonstrate a universal process for transferring planar, transparent functional oxide thin films on to elastomeric polydimethylsiloxane (PDMS) substrates. This process overcomes the challenge of incorporating high-temperature-processed crystalline oxide materials with low-temperature organic substrates. The functionality of the process is demonstrated using indium tin oxide (ITO) thin films to realise fully transparent and flexible resistors. The ITO thin films on PDMS are shown to withstand uniaxial strains of 15%, enabled by microstructure tectonics. Furthermore, zinc oxide was transferred to display the versatility of this transfer process. Such a ubiquitous process for the transfer of functional thin films to elastomeric substrates will pave the way for touch sensing and energy harvesting for displays and electronics with flexible and transparent characteristics. A universal process for transferring planar, transparent functional oxide thin films on to elastomeric polydimethylsiloxane (PDMS) substrates is demonstrated. This overcomes the challenge of incorporating high-temperature-processed crystalline oxide materials with low-temperature organic substrates. The process is demonstrated using indium tin oxide (ITO) thin films to realise fully transparent and flexible resistors and zinc oxide thin films. The ITO thin films on PDMS are shown to withstand uniaxial strains of 15%, enabled by microstructure tectonics. This ubiquitous process will pave the way for touch sensing and energy harvesting for displays and electronics with flexible and transparent characteristics. Sharath Sriram, Madhu Bhaskaran and colleagues have developed a process for the transfer of high-temperature functional oxides onto flexible substrates, and used it to construct stretchable electrodes that can bear high strains. Structures of indium tin oxide (ITO) — a widely used transparent metallic conductor —were fabricated on a silicon wafer coated with platinum, and casted onto an elastic polymer substrate, polydimethylsiloxane (PDMS). The platinum–ITO–PDMS film is then easily peeled off, as platinum poorly adheres to the silicon substrate; the platinum layer is subsequently removed. When the resulting ITO–PDMS film is stretched, the ITO layer cracks into small, movable plates that remain connected with each other and are therefore still electrically conducting. The high flexibility of the plates means that the ITO–PDMS structure can withstand strains of up to 15%. These conducting structures may find applications in transparent flexible electronics, for example in displays, energy harvesters, or solar cells.
High-Efficiency Dual-Band Filtering Doherty Power Amplifier Based on Multi-Function Circuit (2022)

This article presents a high-efficiency dual-band filtering Doherty power amplifier (DPA) using multi-function circuits for simplifying the structure. A dual-band filtering power combiner also plays the role of real-to-real impedance matching, in which one resonator is shared by both the power combing and filtering circuits. Thus, only one extra resonator is needed for the power combiner to provide second-order dual-band filtering responses, which contributes to high efficiency of the DPA. Transmission zeros are generated between the two passbands, realizing a sharp roll-off rate and greatly enhancing the isolation between the two passbands. Meanwhile, an impedance control network is designed to simultaneously suppress the harmonics and transform the optimized complex impedance desired by the transistor to a real one. In this way, the output matching network and extra filter in conventional design are realized by the filtering power combiner and impedance control network in the proposed design, resulting in a simpler structure. A dual-band DPA operating at 2.14 and 2.6 GHz is implemented with the measured peak efficiencies of 64.4&#x0025; and 69&#x0025; at the output power of 43.25 and 43.3 dBm, respectively. The 6-dB back-off efficiencies are 50&#x0025; and 57&#x0025; at the two passbands. Under 20-MHz long term evolution (LTE) modulated signals with a peak-to-average power ratio (PAPR) of 7.5 dB, the DPA after digital predistortion (DPD) is measured with an adjacent channel leakage ratio (ACLR) of better than &#x2212;45.2 dBc and the efficiencies of 51.6&#x0025; and 54.3&#x0025; at interested bands. The peak efficiency under the excitation of the concurrent modulated signal is 48.6&#x0025;.
QOAR: Adaptive QoS Scheme in Multi-Rate Wireless LANs (2008)

With the availability of multiple rates in IEEE 802.11 a/b/g wireless LANs, it is desirable to improve the network capacity and temporal fairness by sending multiple consecutive frames over high rate links, as proposed in opportunistic auto rate (OAR [1]). However, the basic OAR does not provide quality of service (QoS) guarantee and thus is not sufficient in supporting real time voice/video traffic. In this paper, we further enhance the OAR protocol with a set of QoS mechanisms. The proposed QOAR protocol consists of two protocols: (i) a traffic- differentiating flow weight adaptation protocol (FWA) that dynamically tunes both contention window and concatenation number per channel access; (ii) an admission control protocol (AC) that guarantees the bandwidth/delay requirements of multimedia services. Extensive simulation studies show that QOAR enables QoS for real-time traffic yet maximizes performance of best effort traffic.
Corneal laser surgery (1995)

Myopic PRK with the VISX excimer laser the US experience photorefractive keratectomy with the summit excimer laser correction of high myopia with the excimer laser computerized corneal topography of surface ablations with the TOMEY (TMS) system radial keratotomy and excimer laser photoablation for the correction of myopia solid state photoablative decomposition the NOVATEC laser laser correction of hyperiopia. (Part contents).
Integrating a QPSK Quantum Key Distribution Link (2006)

We present the integration of the optical and electronic subsystems of a BB84-QKD fiber link. A high speed FPGA MODEM generates the random QPSK sequences for a fiber-optic delayed self-homodyne scheme using APD detectors.
OpenRAN Gym: An Open Toolbox for Data Collection and Experimentation with AI in O-RAN (2022)

Open Radio Access Network (RAN) architectures will enable interoperability, openness, and programmatic data-driven control in next generation cellular networks. However, developing scalable and efficient data-driven algorithms that can generalize across diverse deployments and optimize RAN performance is a complex feat, largely unaddressed as of today. Specifically, the ability to design efficient data-driven algorithms for network control and inference requires at a minimum (i) access to large, rich, and heterogeneous datasets; (ii) testing at scale in controlled but realistic environments, and (iii) software pipelines to automate data collection and experimentation. To facilitate these tasks, in this paper we propose OpenRAN Gym, a practical, open, experimental toolbox that provides end-to-end design, data collection, and testing workflows for intelligent control in next generation Open RAN systems. OpenRAN Gym builds on software frameworks for the collection of large datasets and RAN control, and on a lightweight O-RAN environment for experimental wireless platforms. We first provide an overview of OpenRAN Gym and then describe how it can be used to collect data, to design and train artificial intelligence and machine learning-based O-RAN applications (xApps), and to test xApps on a softwarized RAN. Then, we provide an example of two xApps designed with OpenRAN Gym and used to control a large-scale network with 7 base stations and 42 users deployed on the Colosseum testbed. OpenRAN Gym and its software components are open source and publicly-available to the research community.
Hybrid fiber optic sensors (1990)

For more than 10 years, fiber optic sensors have been projected as a dominant sensor technology for the future. This projection has yet to be realized. There continues to be a substantial level of research and development in various fiber sensors concepts, yet only a few products are available commercially. The major factors limiting the success of the fiber sensors in the marketplace will be identified. An alternate approach to fiber sensors is described which takes a systems approach to producing fiber sensors. It combines the advantages of optical fibers with the low-power electronic sensor technology currently available. A single multimode fiber connected between the readout is converted to electricity at the transducer. Optical energy transmitted from the readout is converted to electricity at the transducer. Digital data from the transducer are synchronously transmitted over the fiber to the readout. Magnetic (i.e., current), temperature, position, and proximity sensors have been built and will be described. A discussion comparing optical and electrical sensors is also included.
Targeting the Intestine to Treat Osteoporosis (2018)

Osteoporosis is estimated to affect 200 million women worldwide. After the age of 50, 1 in 3 women and 1 in 5 men will experience an osteoporotic fracture and its associated pain, increased dependency, morbidity and mortality (National Osteoporosis Foundation). While there are a variety of pharmaceuticals available to treat osteoporosis, the number of people with osteoporosis continues to grow. This is in part due to reduced treatment compliance and reduced prescriptions for osteoporosis medications (Khosla and Shane, 2016). Thus, there is a need for expansion of safe, non‐prescription based treatment options for prevention or treatment of early stage osteoporosis. My talk will discuss development of therapeutics targeting the gut‐bone axis, which represents a novel, rapidly growing area of research. Reports from our lab and others indicate a key role for the microbiota in regulating bone density. Prebiotic and probiotic modulation of the intestinal microbiota and gut function is demonstrated to benefit bone health parameters in animal models and humans. Our studies and reports by others indicate that bone responses to gut manipulations are regulated by many factors including sex hormones, inflammation status, disease condition and age. Identification of specific signaling mechanisms (gut barrier function, microbiota composition, probiotic metabolites and secretory factors) will lead to further optimization of straightforward and cost‐effective treatments. Support or Funding Information NIH DK101050, NIH AT007695 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Radiographing the High-Speed Implosion of Condensed Liner at 35 MA Current Prodused by Explosive Magnetic Generator (2005)

The high-speed implosion of a condensed liner is an efficient method to achieve the state of substance characterized by high energy density, temperature and pressure. The experimental procedure for radiographing the perturbations growing in the cylindrical aluminum liner having the walls 2 mm thick, which is imploded under the effect of 35 MA pulses produced by high-power explosive magnetic disk generator (DEMG), is described. System shielding the X-ray film situated at a distance of ~ 40 sm from HE explosive of ~ 100 kg in the explosive magnetic generator is described in detail. Specially arranged units having low total thickness equivalent to shield the film ~ 15 mm of aluminum were used to provide the necessary protection from damage but still allowed the needed picture contrast. The developed procedure demonstrates the efficiency of EMG in the experiments on pulsed hydrodynamics and high-speed implosion of liners.
Excellent optoelectrical properties of graphene oxide thin films deposited on a flexible substrate by Langmuir–Blodgett assembly (2013)

Transparent conductive films (TCFs) composed of ultra-large graphene oxide (GO) sheets are produced on a flexible poly(ethylene terephthalate) (PET) substrate using the Langmuir–Blodgett (L–B) assembly. The GO films are reduced using hydriodic (HI) acid followed by chemical doping treatments. The TCFs deliver excellent optoelectrical properties with a remarkable sheet resistance 1100 Ω sq−1 at a transmittance of 91%, which is considered among the best. The plasma-treated PET substrate plays an important role in determining the chemistry and surface morphology of GO films: a combination of strong covalent bonds and π–π interactions between the GO and PET is revealed. The L–B assembly technique is suitable for the fabrication of flexible TCFs of optoelectronic devices on a large scale.
Rotating Principal Stress Axes in High-Cycle Fatigue (1967)

A new modified octahedral shear stress failure theory for high-cycle fatigue has been developed. This theory considers rotating principal stress axes and nonsynchronous stresses. This theory was then compared to the commonly used octahedral shear stress theory using data from the literature. The new theory was found to be significantly better in predicting failures.
Integration of monopole slot and monopole strip for internal WWAN handset antenna (2012)

Abstract A novel internal handset antenna formed by a monopole slot and a monopole strip for the wireless wide area network (WWAN) operation in the 824–960 and 1710–2170 MHz bands is presented. The monopole strip is disposed in the monopole slot, and both are embedded in the system ground plane of the handset with a small board space of 9 × 40 mm 2 at about the bottom edge of the circuit board. The monopole strip serves as a feed for the monopole slot and also functions as an efficient radiator. In the proposed design, the monopole slot generates a quarter‐wavelength slot mode in the antenna's lower band, while the monopole strip contributes its quarter‐wavelength mode in the antenna's upper band. By including a vertical strip that can be enclosed inside the handset casing or be a part of the bezel surrounding, the periphery of the handset casing and connected to the bottom edge of the system ground plane, the impedance matching of the excited slot mode can be greatly improved. In this case, the proposed antenna can provide two wide operating bands with good impedance matching to cover the pentaband WWAN operation. Detailed operating principle of the integrated monopole slot and monopole strip for the internal WWAN handset antenna is described. The proposed antenna is also fabricated and obtained results are presented and discussed. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:1718–1723, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26870
Mechanisms of recovery from mechanical injury of cultured rat hepatocytes (1996)

The mechanism(s) whereby hepatocytes restore denuded areas remains unknown. We therefore studied the recovery of denuded areas made in monolayers of primary cultures of rat hepatocytes. Minimal recovery occurred in cells plated on plastic. Plating on Matrigel produced modest recovery (25% at 24 h), whereas plating on a type I collagen substrate resulted in &gt; 70% recovery at 24 h. The rate of recovery on collagen could be attenuated by a monoclonal antibody directed against the extracellular domain of the beta 1-integrin subunit. Monoclonal antibodies directed against CD44 (the hyaluron receptor) and E-cadherin did not influence the rate of recovery. Recovery could be stimulated, in a dose-dependent fashion, by epidermal and hepatocyte growth factors. The effects of epidermal and hepatocyte growth factors to promote recovery occurred in the absence of 5-bromo-2'-deoxyuridine uptake, suggesting a proliferation-independent mechanism. Transforming growth factor-beta 1 inhibited recovery. Exposure to selected cytokines (interleukins 1 and 2), an adenine nucleotide [adenosine 5'-O-(3-thiotriphosphate)], adenosine, pertussis toxin, and selected agents that bind to fibronectin and other matrix component adhesive sites (heparin and the RGD peptide) did not influence the rate of recovery of hepatocytes. However, the peptide DGEA, which can bind to collagen adhesive sites, attenuated recovery. These studies demonstrate that primary cultures of rat hepatocytes require a particular type of extracellular matrix to renew denuded areas and that the beta 1-integrin subunit may be involved in this recovery process. Hepatocyte recovery of denuded areas can be modulated by growth factors in both a stimulatory (epidermal and hepatocyte growth factors) and an inhibitory (transforming growth factor-beta 1) fashion.
Liquid Cooling Applications in Twin Builder- Industrial Paper (2019)

This industrial paper introduces the new Liquid Cooling Library (LCL) that is available in ANSYS Twin Builder Heating and Cooling Library bundle. This library is a multi-tool compatible Modelica Library which can help customers to deploy simulation of cooling systems in a new way. In general, LCL can be used for modeling cooling circuits across many industries like aerospace, automotive and process industry. The combination with the extensive electronics and electrical machine libraries in Twin Builder makes LCL a natural fit for cooling of power electronics and thermal management of electric vehicles.
Liver Regeneration (2003)

Koniaris, Leonidas G MD, FACS*, **; McKillop, Iain H PhD*; Schwartz, Seymour I MD, FACS*; Zimmers, Teresa A PhD* Author Information