gebhart/patrepeval huggingface dataset:
An Evaluation of Autoregressive Spectral Estimation Model Order for Brain-Computer Interface Applications (2006)

Autoregressive (AR) spectral estimation is a popular method for modeling the electroencephalogram (EEG), and therefore the frequency domain EEG phenomena that are used for control of a brain-computer interface (BCI). Several studies have been conducted to evaluate the optimal AR model order for EEG, but the criteria used in these studies does not necessarily equate to the optimal AR model order for sensorimotor rhythm (SMR)-based BCI control applications. The present study confirms this by evaluating the EEG spectra of data obtained during control of SMR-BCI using different AR model orders and model evaluation criteria. The results indicate that the AR model order that optimizes SMR-BCI control performance is generally higher than the model orders that are frequently used in SMR-BCI studies
Assessment of nutrient use in annual and perennial crops: A functional concept for analyzing nitrogen use efficiency (2010)

The use of more nutrient-efficient crops is important for maintaining yields while enhancing environmental sustainability. Various approaches are being applied to evaluate aspects of plant nutrient use efficiency, among them ecological concepts based on accumulation and losses of biomass and nutrients, agronomic concepts with a major focus on agricultural crops and harvested products, and physiological approaches assessing single physiological processes important for nutrient use. Unfortunately, the various approaches are often not compatible. Here we propose, with the example of nitrogen (N) use efficiency (NUE) of cereals, to integrate the functionally important components of NUE in a common conceptual framework. We link productivity to N in crops and seeds and consider the whole life-cycle of the crop (including seeds). Three major components of NUE are separated: The N uptake efficiency, grain-specific N efficiency and grain N concentration. The three components combine to a measure of overall NUE in terms of the N yield in harvested grain per unit of N in seed grain or soil N. The concept can be applied for both annual and perennial plants, which is demonstrated with the examples of winter wheat and a perennial energy crop (Salix) grown in Central Sweden.
International comparison of observation-specific spatial buffers: maximizing the ability to estimate physical activity (2017)

Results of this study inform the selection of spatial buffering methods to estimate physical activity outcomes using an internationally consistent set of BEMs. Using three different network-based buffering methods, the findings indicate significant variation among BEM values, however associations with physical activity outcomes were similar across each buffering technique. The study advances knowledge by presenting consistently assessed relationships between three different network buffer types and utilitarian travel, sedentary behavior, and leisure-oriented physical activity outcomes.
Changes of calmodulin and S-100 protein in C6 glioma cells as a result of cellular differentiation induced by forskolin. (1986)

and S-100 protein in C6 glioma cells as a result of cellular differentiation induced by forskolin.
Chromium Supplementation for Menstrual Cycle-Related Mood Symptoms (2013)

These preliminary observations suggest that chromium may be a useful monotherapy or adjunctive therapy for women suffering from significant menstrual cycle-related symptoms. Larger, controlled studies are needed to evaluate the efficacy of chromium treatment in this patient population.
Impact of NLOS on the path loss and channel capacity of a MIMO off-body system inside a mine (2017)

In this paper, the impact of NLOS on the path loss and channel capacity of MIMO Off-Body system using patch antenna is proposed. The improvement offered by multiple-input multiple-output (MIMO) systems is investigated at non-line-of-sight (NLOS) situations in terms of capacity and path-loss (PL). Measurements were performed in a real gold mine. results show a correlation between PL and channel capacity. The effect of directive antennas and that of obstructed channel are discussed.
A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours (2009)

Imatinib at 440 mg/m(2)/day is relatively safe in children with recurrent CNS tumours, but induced no objective responses. Demonstration of SD in previously progressing patients (KIT-expressing) suggests cytostatic activity of imatinib.
A Novel Peak Power Supply Noise Measurement and Adaptation System for Integrated Circuits (2015)

For 45-nm technologies and below, the maximum operation frequency of integrated circuits (ICs) has reached multiple gigahertz. At the same time, the size of modern ICs has increased significantly with several billions of transistors integrated on each die. When a large number of transistors switch at the same time, high current consumption is generated. The high current consumption combining with the parasitic resistance and inductance of the power supply network generates a significant power supply noise peak, which causes abnormal reset and generates excessive radiation emission, and hence needs to be accurately monitored, adapted, and mitigated. This paper presents a novel power supply noise measurement and adaptation system that can monitor the peak power supply noise and make dynamic adaptation within one clock cycle. The proposed system has been implemented in Nangate 45-nm technology. It has been proved that the proposed measurement and the adaptation system can successfully avoid the performance degradation or functional failure due to excessive power supply noise. The peak power supply noise monitoring accuracy is 5 mV. The adaptation reaction time is 75%-100% of single system clock cycle. The proposed system is robust against temperature and process variation, and of negligible area overhead and power consumption.
Acute effect of different antidepressants on glycemia in diabetic and non-diabetic rats (2001)

Diabetic patients have a 20% higher risk of depression than the general population. Treatment with antidepressant drugs can directly interfere with blood glucose levels or may interact with hypoglycemic agents. The treatment of depression in diabetic patients must take into account variations of glycemic levels at different times and a comparison of the available antidepressant agents is important. In the present study we evaluated the interference of antidepressants with blood glucose levels of diabetic and non-diabetic rats. In a first experiment, male adult Wistar rats were fasted for 12 h. Imipramine (5 mg/kg), moclobemide (30 mg/kg), clonazepam (0.25 mg/kg), fluoxetine (20 mg/kg) sertraline (30 mg/kg) or vehicle was administered. After 30 min, fasting glycemia was measured. An oral glucose overload of 1 ml of a 50% glucose solution was given to rats and blood glucose was determined after 30, 60 and 90 min. Imipramine and clonazepam did not change fasting or overload glycemia. Fluoxetine and moclobemide increased blood glucose at different times after the glucose overload. Sertraline neutralized the increase of glycemia induced by oral glucose overload. In the second experiment, non-diabetic and streptozotocin-induced diabetic rats were fasted, and the same procedures were followed for estimation of glucose tolerance 30 min after glucose overload. Again, sertraline neutralized the increase in glycemia after glucose overload both in diabetic and non-diabetic rats. These data raise the question of whether sertraline is the best choice for prolonged use for diabetic individuals, because of its antihyperglycemic effects. Clonazepam would be useful in cases with potential risk of hypoglycemia.
Orientation of Diamagnetic Layered Transition Metal Oxide Particles in 1-Tesla Magnetic Fields (2011)

The magnetic field-driven orientation of microcrystals of six diamagnetic layered transition metal oxides (HLaNb(2)O(7), HCa(2)Nb(3)O(10)·0.5H(2)O, KNaCa(2)Nb(4)O(13), KTiTaO(5), KTiNbO(5), and H(2.2)K(1.8)Nb(6)O(17)·nH(2)O) suspended in epoxy resins was studied by X-ray diffraction using permanent magnets producing a 0.8 T field. Although the degree of orientation, quantified as the Hermans order parameter, was strongly affected by the particle size distribution, in all cases microcrystals with ∼1-2 μm lateral dimensions were found to orient with the magnetic field vector in the layer plane. Control of the orientation of ionically conducting layered oxides is of interest for practical applications in batteries and fuel cells. The consistent direction of orientation of the lamellar oxides studied can be rationalized in the framework of a quantitative bond anisotropy model developed by Uyeda (Phys. Chem. Miner.1993, 20, 77-80). The asymmetry of metal-oxygen bonding at the faces of the octahedral layers results in long and short M-O bonds perpendicular to the plane of the sheets. This distortion of the M-O octahedra, which is a structural feature of almost all layered materials that contain octahedral bonding frameworks, gives rise to the diamagnetic anisotropy and results in an easy axis or plane of magnetization in the plane of the sheets.
Analysis of transmit antenna selection/switch-and-examine combining over Nakagami-m fading channels (2012)

In this paper, we analyze a diversity system with the transmit antenna selection (TAS) at the transmitter and the switch-and-examine combining (SEC) at the receiver over a Nakagami-m fading channel. This system has lower complexity as compared to the TAS schemes with maximum-ratio combining and generalized selection combining at the receiver. Furthermore, the TAS/SEC scheme requires a smaller number of branch estimations compared to the TAS/SC scheme. The performance of the TAS/SEC system with binary phase-shift keying over a Nakagami-m fading channel is examined. The expressions of the average output signal-to-noise ratio and bit-error rate are derived and presented.
Automatic Conversational Scene Analysis in Children with Asperger Syndrome/High-Functioning Autism and Typically Developing Peers (2014)

Individuals with Asperger syndrome/High Functioning Autism fail to spontaneously attribute mental states to the self and others, a life-long phenotypic characteristic known as mindblindness. We hypothesized that mindblindness would affect the dynamics of conversational interaction. Using generative models, in particular Gaussian mixture models and observed influence models, conversations were coded as interacting Markov processes, operating on novel speech/silence patterns, termed Steady Conversational Periods (SCPs). SCPs assume that whenever an agent's process changes state (e.g., from silence to speech), it causes a general transition of the entire conversational process, forcing inter-actant synchronization. SCPs fed into observed influence models, which captured the conversational dynamics of children and adolescents with Asperger syndrome/High Functioning Autism, and age-matched typically developing participants. Analyzing the parameters of the models by means of discriminative classifiers, the dialogs of patients were successfully distinguished from those of control participants. We conclude that meaning-free speech/silence sequences, reflecting inter-actant synchronization, at least partially encode typical and atypical conversational dynamics. This suggests a direct influence of theory of mind abilities onto basic speech initiative behavior.
Synthesis of aromatic modified prostaglandins from PGA2 (1983)

A general synthetic scheme, starting from PGA2(obtained from the marine coral Plexaura homomalla), of prostaglandins modified in the upper chain is detailed. Key aldehyde intermediates have been secured from 11-deoxy-PGF2α and PGF2α by an efficient regioselective hydroxylation procedure followed by cleavage of the 5,6-double bond. Wittig reaction with these aldehydes provided the novel prostaglandins (5)–(8), belonging to the E and F families, and containing an aromatic ring in the upper chain.
Susceptibility Testing Is Key for the Success of Cefiderocol Treatment: A Retrospective Cohort Study (2021)

Cefiderocol is a novel siderophore cephalosporin, which has proven in vitro activity against carbapenem-resistant (CR) Gram-negative pathogens and stability towards all carbapenemases. The aim of this study was to describe the first cases of prescriptions and the efficacy of cefiderocol for compassionate use in the 2 months following its access in France. We performed a national retrospective study of all patients who received at least one dose of cefiderocol from 2 November 2018 to 5 November 2019. We collected clinical characteristics and outcome through a standard questionnaire. Bacterial isolates from 12 patients were centralized and analyzed in the French National Reference Center for Antimicrobial Resistance, and sequenced using Illumina technology. Finally, 13 patients from 7 French university hospitals were included in the study. The main type of infection treated by cefiderocol was respiratory tract infections (RTI, <i>n</i> = 10). The targeted bacteria were <i>Pseudomonas aeruginosa</i> (<i>n</i> = 12), including carbapenemase-producing <i>P. aeruginosa</i> (<i>n</i> = 9), <i>Acinetobacter baumannii</i> (<i>n</i> = 2), <i>Klebsiella pneumoniae</i> (<i>n</i> = 1), and <i>Enterobacter hormaechei</i> (<i>n</i> = 1). Overall, of the 12 patients whose samples were analyzed, 5 <i>P. aeruginosa</i> strains were not susceptible to cefiderocol (4 categorized as resistant and 1 as intermediate) according to Clinical and Laboratory Standards Institute (CLSI) breakpoints. If considering susceptible strains, the cure rate was 6/7, while being 0/5 among not-susceptible strains. This study underlines the necessity to test strains in adequate conditions.
High Tech Start-ups: More Than High Tech (2009)

Join us as we talk with John Ketchersid, Chief Technology Officer for the Atlanta Seed Fund about issues relevant to start-up companies in the high tech arena.
Neuroprotection by Caffeine and A2AAdenosine Receptor Inactivation in a Model of Parkinson's Disease (2001)

Recent epidemiological studies have established an association between the common consumption of coffee or other caffeinated beverages and a reduced risk of developing Parkinson's disease (PD). To explore the possibility that caffeine helps prevent the dopaminergic deficits characteristic of PD, we investigated the effects of caffeine and the adenosine receptor subtypes through which it may act in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin model of PD. Caffeine, at doses comparable to those of typical human exposure, attenuated MPTP-induced loss of striatal dopamine and dopamine transporter binding sites. The effects of caffeine were mimicked by several A 2A antagonists (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (SCH 58261), 3,7-dimethyl-1-propargylxanthine, and (E)-1,3-diethyl-8 (KW-6002)-(3,4-dimethoxystyryl)-7-methyl-3,7-dihydro-1Hpurine-2,6-dione) (KW-6002) and by genetic inactivation of the A 2A receptor, but not by A 1 receptor blockade with 8-cyclopentyl-1,3dipropylxanthine, suggesting that caffeine attenuates MPTP toxicity by A 2A receptor blockade. These data establish a potential neural basis for the inverse association of caffeine with the development of PD, and they enhance the potential of A 2A antagonists as a novel treatment for this neurodegenerative disease.
Ischemic/bleeding event after short dual-antiplatelet therapy in patients with high bleeding risk: Sub-analysis of the MODEL U-SES study (2021)

In contemporary PCI practice, nearly half of patients had HBR and presence of HBR significantly increased risk of ischemic/thrombotic events. Both aspirin and P2Y<sub>12</sub> inhibitor monotherapy following short DAPT had low and comparable ischemic/bleeding events.
Autonomous Landing of an UAV Using H∞ Based Model Predictive Control (2022)

Possibly the most critical phase of an Unmanned Air Vehicle (UAV) flight is landing. To reduce the risk due to pilot error, autonomous landing systems can be used. Environmental disturbances such as wind shear can jeopardize safe landing, therefore a well-adjusted and robust control system is required to maintain the performance requirements during landing. The paper proposes a loop-shaping-based Model Predictive Control (MPC) approach for autonomous UAV landings. Instead of conventional MPC plant model augmentation, the input and output weights are designed in the frequency domain to meet the transient and steady-state performance requirements. Then, the H∞ loop shaping design procedure is used to synthesize the state-feedback controller for the shaped plant. This linear state-feedback control law is then used to solve an inverse optimization problem to design the cost function matrices for MPC. The designed MPC inherits the small-signal characteristics of the H∞ controller when constraints are inactive (i.e., perturbation around equilibrium points that keep the system within saturation limits). The H∞ loop shaping synthesis results in an observer plus state feedback structure. This state estimator initializes the MPC problem at each time step. The control law is successfully evaluated in a non-linear simulation environment under moderate and severe wind downburst. It rejects unmeasured disturbances, has good transient performance, provides an excellent stability margin, and enforces input constraints.
Multiple crossed-beam ultrasound Doppler velocimetry (1978)

A new ultrasound Doppler technique for obtaining calibrated 3D flow velocity information is reported. Theoretical expressions are derived for the expected Doppla shift and the spectral spread under a variety of flow conditions. Experimental results using a revolv-) ing turntable demonstrated the linearity of velocity detection, the ability to resolve an arbitrary velocity vector, and conrimed the theoretical predictions of spectral spread.
Vision-based navigation and environmental representations with an omnidirectional camera (2000)

Proposes a method for the visual-based navigation of a mobile robot in indoor environments, using a single omnidirectional (catadioptric) camera. The geometry of the catadioptric sensor and the method used to obtain a bird's eye (orthographic) view of the ground plane are presented. This representation significantly simplifies the solution to navigation problems, by eliminating any perspective effects. The nature of each navigation task is taken into account when designing the required navigation skills and environmental representations. We propose two main navigation modalities: topological navigation and visual path following. Topological navigation is used for traveling long distances and does not require knowledge of the exact position of the robot but rather, a qualitative position on the topological map. The navigation process combines appearance based methods and visual servoing upon some environmental features. Visual path following is required for local, very precise navigation, e.g., door traversal, docking. The robot is controlled to follow a prespecified path accurately, by tracking visual landmarks in bird's eye views of the ground plane. By clearly separating the nature of these navigation tasks, a simple and yet powerful navigation system is obtained.
Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target (2019)

Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug resistance, cancer stem cell survival and stemness, and invasion and migration. TG2 can exist in a GTP-bound signaling-active conformation or in a transamidase-active conformation. The GTP bound conformation of TG2 contributes to cell survival and the transamidase conformation can contribute to cell survival or death. We present evidence suggesting that TG2 has a role in human cancer, summarize what is known about the TG2 mechanism of action in a range of cancer types, and discuss TG2 as a cancer therapy target.
Obstructive sleep apnea is an independent predictor for dyslipidemia: Data from the European Sleep Apnea Database (ESADA) (2017)

<b>Background and aim:</b> Obstructive sleep apnea (OSA) and dyslipidemia are both independently well-recognized risk factors for cardiovascular disease. Previous data are inconclusive regarding the relationship between OSA and dyslipidemia. The aim of the present study was to investigate the association between OSA and dyslipidemia in ESADA (European Sleep Apnea Database). <b>Methods:</b> The cross-sectional analysis included 8592 patients (age 50.1±12.7 years, 69.1% male, BMI 30.8±6.6 kg/m2, mean AHI 25.7±25.9 n/h) from the ESADA. The independent relationship between measures of OSA (AHI, ODI, mean and lowest saturation) and lipid profile (total cholesterol [TC], HDL-cholesterol [HDL-C] (n=3289) and fasting triglyceride [TG] (n=4612)) was determined by means of General Linear Model analysis. Patients with known hyperlipidemia and/or lipid-lowering medication were excluded. <b>Results:</b> TC had a strong linear association with ODI (mean±SE [mg/dl] 180.33±2.46, 184.59±2.42, 185.44±2.42 and 185.73±2.44; p&lt;0.001 for ODI quartiles I-IV). Comparable results were seen for AHI, mean and lowest saturation. TG were slightly better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest quartile of AHI (mean±SE [mg/dl] 48.8±1.49 vs. 46.50±1.48; p=0.002, quartile I vs. IV). Morbid obesity was associated with lower TC and higher HDL-C values. European regions influenced lipid status, patients from the North had highest and from the West had lowest TC values (mean±SE [mg/dl] 192.55±2.27 versus 177.80±2.75, p&lt;0.001). <b>Conclusion:</b> OSA has an independent association with dyslipidemia, but the effect size is limited.
Catalytic Enantioselective Cyano‐Trifluoromethylation of Styrenes (2017)

Abstract Reported herein is the catalytic enantioselective cyano‐trifluoromethylation of styrenes allowing a straightforward preparation of a new structural class of fluorine‐containing compounds. We demonstrate that the desired transformation can be successfully realized using catalytic system of Cu(II)/chiral bidentate bis(oxazoline) ligand, TMS‐CN and Togni reagents, as sources of the CN and CF 3 groups, respectively. Preliminary results strongly suggest synthetic potential of this method as the target cyano‐trifluoromethylated products can be generally obtained with high chemical yields (59‐90 %) and excellent enantiomeric purity (91‐98 % ee).
A study of timing and frequency synchronization scheme in VSB systems for terrestrial 3D HDTV broadcasting (2012)

In this paper, we study the performance of a synchronization scheme in VSB modulation systems for terrestrial 3-D HDTV broadcasting. The synchronization scheme consisted of the symbol timing recovery, the frame controlling and the carrier recovery. The proposed scheme shows a bit error rate (BER) performance that is almost the same as the ideal synchronization in VSB modulation systems.
Catabolic mediators of cancer cachexia (2008)

These results suggest that blocking the PIF receptor or signalling pathways in skeletal muscle might yield new types of agents for the treatment of cancer cachexia.
α-Aminoallylation of aldehydes in aqueous ammonia (2004)

alpha-Aminoallylation of aldehydes in aqueous ammonia has been developed; commercial aqueous ammonia was successfully used, and this method does not require anhydrous conditions thus leading to easy and practical operations.