gebhart/patrepeval huggingface dataset:
The Paraffin Hydrocarbons of Wool Wax. Homologous Series of Methyl Alkanes* (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Paraffin Hydrocarbons of Wool Wax. Homologous Series of Methyl Alkanes*James D. Mold, Richard E. Means, Robert K. Stevens, and John M. RuthCite this: Biochemistry 1966, 5, 2, 455–461Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/bi00866a009https://doi.org/10.1021/bi00866a009research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthetic Trehalose Dicorynomycolate(S-TDCM): Behavioral Effects and Radioprotection. (1997)

This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation (n) and gamma-photon irradiation. The 30-day survival rates for mice treated with 100-400 micrograms/mouse S-TDCM were significantly enhanced compared to controls. Toxicity of S-TDCM was measured in nonirradiated mice by locomotor activity, food intake, water consumption, and alterations in body weight. A dose-dependent decrease was noted in all behavioral measures in mice treated with S-TDCM. Doses of 100 and 200 micrograms/mouse S-TDCM significantly reduced motor activity beginning 12 hr postinjection with recovery by 24 hr. A dose of 400 micrograms/mouse significantly decreased activity within the first 4 hr after administration and returned to control levels by 32 hr following injection. Food and water intake were significantly depressed at doses of 200 and 400 micrograms/mouse on the day following drug administration, and were recovered in 24 hr. Body weight was significantly decreased in the 200 micrograms/mouse group for 2 days and in the 400 micrograms/mouse group for 4 days following injection. A dose of 100 micrograms/mouse effectively enhanced survival after fission-neutron irradiation with no adverse effect on food consumption, water intake, or body weight and a minimal, short-term effect on locomotor activity.
Urotensin-II as a novel therapeutic target in the clinical management of cardiorenal disease. (2004)

The pronounced pharmacodynamic effects of human urotensin-II (U-II), a 'somatostatin-like' cyclic undecapeptide, are mediated via the G protein-coupled receptor UT (formerly known as GPR14). Emerging clinical studies implicate U-II in the etiology of several cardiorenal and metabolic disease states in humans. Although the specific pathogenic role(s) of U-II remain to be clearly defined, existing data warrant further clinical investigation. The therapeutic development of specific U-II/UT inhibitors will assist in establishing a causative role for U-II in the progression and/or maintenance of hypertension, heart failure, renal tubular disease and diabetes.
Reply to “Premature Proposal of the Pine Weevil as a Vector of a Human Pathogen” (2014)

We thank [our Swedish colleagues][1] ([1][2]) for reading our paper ([2][3]). We feel honored that our description of the first clinical case of sepsis caused by Capnocytophaga canimorsus, which was most probably vector transmitted, has attracted attention. We feel delighted by the fact that our
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis (2023)

ClinicalTrials.gov, http://clinicaltrials.gov, NCT03444220.
Analytic Wigner distribution function for tunneling and trajectory models (2019)

The Wigner function is assembled from analytic wave functions for a one-dimensional closed system (well with infinite barriers). A sudden change in the boundary potentials allows for the investigation of time-dependent effects in an analytically solvable model. A trajectory model is developed to account for tunneling when the barrier is finite. The behavior of the density (the zeroth moment of the Wigner function) after an abrupt change in potential shows net accumulation and depletion over time for a weighting of energy levels characteristic of the supply function in field emission. However, for a closed system, the methods have application to investigations of tunneling and transmission associated with field and photoemission at short time scales.
T. S. Eliot (2021)

Poet, dramatist, and critic Thomas Stearns Eliot (b. 1888–d. 1965) won fame for such poems as “The Love Song of J. Alfred Prufrock” (1915), The Waste Land (1922), and “The Hollow Men” (1925), which ushered in and helped define the modernist era of literature. His critical writings also shaped literary taste and study in the 20th century. Born and raised in St. Louis, Missouri, by a Unitarian family with deep roots in American history, he was educated at Harvard and wrote his first significant poems during his year abroad in Paris, 1910–1911. After completing most of the work for a PhD in philosophy, he found himself abroad again during the outbreak of World War I, and he decided to marry an Englishwoman, Vivienne Haigh-Wood, and put down roots in London. His first book of poems, Prufrock and Other Observations (1917), surprised readers with its modern vocabulary, free-verse rhythms, and compelling dramatic voices. While working as a teacher and then a banker, Eliot established himself as an authoritative new voice in literary criticism with essays including “Tradition and the Individual Talent” (1919), “Hamlet” (1919), and “The Metaphysical Poets” (1921). He introduced terms that shaped literary study throughout the 20th century: “impersonality,” “the objective correlative,” and “dissociation of sensibility.” In 1920 he collected his early essays in The Sacred Wood and published another volume of poems, including “Gerontion.” His personal life was not happy; he regretted having married a woman he did not love instead of the American girl he left behind in Massachusetts, Emily Hale (during his lifetime he wrote over one thousand letters to her). Considered his greatest work and probably the most significant poem of the 20th century, The Waste Land (1922) expresses his personal emotional conflict in terms of the larger historical currents of the immediate postwar period: the aftershocks of war, a crisis of faith, changing gender roles, urbanization, and a sense of deracination from the past. Erudite, multilingual, and difficult to read, but also highly charged with feeling, this poem captured the spirit of the interwar era, received more sustained attention than any other literary work in the 20th century, and is known and quoted across the globe. Eliot further distinguished himself by converting to the Anglican church in 1927 and becoming its leading poet and dramatist with his conversion poem Ash-Wednesday (1930), the play Murder in the Cathedral (first performed 1935), and the long lyric sequence Four Quartets (1936–1941). He also became a British citizen, so he can be considered both an American and an English writer. In the 1930s and 1940s he turned more toward drama and engaged with cultural and social debates in his criticism from a Christian perspective. Eliot won the Nobel Prize in literature in 1948.
Ni/CeO2 for hydrogen production: The role of metal-support interactions (2015)

A first-principles calculation of the recently discovered interatomic multiatom resonant photoemission (MARPE) effect is presented. In this phenomenon, core photoelectron intensities are enhanced when the photon energy is tuned to a core-level absorption edge of nonidentical neighboring atoms, thus enabling direct determination of near-neighbor atomic identities. Both the multiatom character of MARPE and retardation effects in the photon and electron interactions in the resonant channel are shown to be&#13;\ncrucial. Measured peak-intensity enhancements of 40% in MnO and spectral shapes similar to the corresponding x-ray absorption profiles are well reproduced by this theory.
1P1-J06 Construction of Fuzzy Inference-based Terrain Traversability Analysis Method for Mobile Robots (2015)

This paper describes a novel rough terrain traversability analysis method for a mobile robot navigation. We focused on the scenario of mobile robot operation in disaster environment with limited sensor data. The proposed method enables mobile robots to analyze terrain traversability of surrounding area and select safe course direction in spite of the limited sensor data acquisition area. Terrain traversability analysis and course direction judgment are realized based on feature value calculation of terrain, fuzzy inference and vector field histogram. The experimental results show that the proposed method can select safe course direction of the mobile robot successfully.
Continuous-wave ultraviolet generation at 354nm in a periodically poled MgO:LiNbO3 by frequency tripling of a diode end-pumped Nd:GdVO4 microlaser (2004)

Continuous-wave UV radiation at 354nm, the third harmonic of a Nd:GdVO4 laser operating at 1063nm, is reported from single-pass cascaded, first-order periodically poled MgO:LiNbO3 (PPMgLN) crystals. A high-voltage multipulse poling method was used in order to realize PPMgLN with uniform domain period (Λ) of micron-order width and 50% duty cycle along the entire crystal length. Initially, second-harmonic generation of the 1063nm Nd:GdVO4 laser at 2.1%∕W conversion efficiency, producing 1.15W at 531nm, is obtained from a 10-mm-long PPMgLN with Λ=6.95μm. Sum frequency mixing of this 531nm light with the residual 1063nm fundamental radiation in a 3.6-mm-long PPMgLN with Λ=1.78μm produces 47mW of UV with 3.9%∕W∕cm normalized conversion efficiency.
ChemInform Abstract: Caffeine and Related Purine Alkaloids: Biosynthesis, Catabolism, Function and Genetic Engineering (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Towards Applying Logico-numerical Control to Dynamically Partially Reconfigurable Architectures (2015)

International audience
ChemInform Abstract: Aluminum‐ and Gallium‐Containing Open‐Dawson Polyoxometalates. (2016)

Abstract K 10 [{Al 4 (μ‐OH) 6 }{α,α‐Si 2 W 18 O 66 }]·28.5H 2 O (I) and K 10 [{Ga 4 (μ‐OH) 6 } (α,α‐Si 2 W 18 O 66 )] ·25H 2 O (II) are prepared in 14 and 26% yield, resp., by the reaction of a 1:2 aqueous molar mixture of the trilacunary Keggin compounds Na 10 [A‐α‐SiW 9 O 34 ] or K 10 [A‐α‐SiW 9 O 34 ] with Al(NO 3 ) 3 or Ga(NO 3 ) 3 , resp.
DREADD: A Chemogenetic GPCR Signaling Platform (2020)

Recently, we created a family of engineered G protein-coupled receptors (GPCRs) called DREADD (designer receptors exclusively activated by designer drugs) which can precisely control three major GPCR signaling pathways (Gq, Gi, and Gs). DREADD technology has been successfully applied in a variety of in vivo studies to control GPCR signaling, and here we describe recent advances of DREADD technology and discuss its potential application in drug discovery, gene therapy, and tissue engineering.
Production of High-Value Proteins under Stringent Cost Constraints—The Case of Hollow Fiber Technology for Cell Culture (2023)

For decades, the benefits of utilizing hollow fiber bioreactors for continuous cell culture to produce monoclonal antibodies have been widely recognized. However, the suitability of this technology for laboratories or centers with limited resources and expertise seeking to expand their production capacity is uncertain, mainly due to unknown cost-effectiveness. In this study, a hollow fiber bioreactor with a 4.7-mL culture volume was used to culture a hybridoma clone producing immunoglobulin G antibody specific to hemoglobin F (HbF). The antibody reached a maximum concentration of 1.22 g/L and totaled 21 mg over a 44-day culture period. This preliminary production data was used to estimate the cost of consumables required for using the hollow fiber bioreactor to produce 130 mg of monoclonal antibodies, which was found to be THB35.8k (£880). The cost was slightly more expensive than batch cultivation in typical culture dishes, which ranged from THB27.8 to 30.2k (£680 to 740). Despite the advantages in terms of reduced hands-on time, shorter production duration, and highly concentrated products, the primary challenges associated with using hollow fiber bioreactors were the cost and availability of the cartridges.
Microscopie électronique à haute tension (1968)

L'auteur, après avoir rappelé brièvement le principe d'un microscope électronique par transmission, essaie de dégager quelques domaines d'application que la microscopie électronique à haute tension permettrait d'étudier efficacement. Il semble que deux questions sont à résoudre en priorité : l'étude des contrastes et celle des défauts ponctuels qui doivent être créés si la tension est assez élevée.
Comparative Synergistic Activity of Nafcillin, Oxacillin, and Methicillin in Combination with Gentamicin Against Enterococci (1975)

The effectiveness of three semisynthetic, penicillinase-resistant penicillins alone and in combination with gentamicin was tested against 29 clinical isolates of enterococci. The minimal inhibitory concentrations of nafcillin were considerably lower than those of oxacillin and methicillin but were slightly higher than those of penicillin. At clinically achievable concentrations, the combination of nafcillin plus gentamicin produced enhanced killing against 13 of 14 strains of enterococci and was synergistic (by very rigid criteria) against 10 of 14 strains. In contrast, combinations of oxacillin plus gentamicin were synergistic against only 3 of 14 strains, and methicillin plus gentamicin produced synergistic killing against only 1 of 14 strains.
Ultrafast All-Optical Switching in an AlGaAs X-Junction (1992)

Several recent experiments have verified the existence of relatively large refractive nonlinearities in the region of half the band gap of AlGaAs and GaAs/AlGaAs quantum well structures1-3. Working in this wavelength region has several advantages; it minimizes the effects of two-photon absorption (TPA), which has limited the usefulness of previous devices, it gives rise to devices with very low linear loss and hence high throughput, finally, it also allows the material to be chosen so that the operating wavelength is in the low-loss, 1.55 μm, telecommunications window.
Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy (2019)

A facile preparation of nanoparticles with enhanced properties obtained by co-precipitation containing radium-224 and functional groups to connect target (bio)molecules for therapeutic applications in oncology is described.
EVIDENCE THAT A 36kD β2m ASSOCIATED sHLA IS DERIVED FROMβ2m-FREE HLA HEAVY CHAINS CLEAVED FROM ACTIVATED CELLS BY METALLOPROTEASE (1998)

260 Background: We and others have found soluble donor-derivedβ2m associated HLA proteins (sHLA/β2m) in the serum of kidney, pancreas and heart transplant recipients with acute and chronic rejection. We have also shown that β2m-free HLA heavy chains(β2m-free HC) are cleaved from the surface of activated cells via a specific metalloprotease. In addition, recent analysis of broncheoalveolar lavage fluid from lung transplant recipients with poor graft outcome has shown increased sHLA/β2m and β2m-free HC.Hypothesis: The sHLA/β2m detected during allograft rejection is derived from β2m-free HC cleaved by metalloprotease from the surface of activated cells. Methods: To test this hypothesis we determined the concentration and molecular weight of theβ2m-free HC and sHLA/β2m proteins released from PWM activated PBL in the presence and absence of the metalloprotease inhibitor BB9.4. Tissue culture supernatants (TCS) were sampled daily and the concentration of sHLA/β2m and β2m-free HC was determined by specific ELISA. At 4 or 7 days of culture, the tissue culture supernatants were immunoprecipitated with w6/32 or HC-10-coupled Sepharose(for sHLA/β2m or β2m-free HC respectively). The absorbed proteins were separated by SDS-PAGE, and subjected to Western blot analysis with antibodies specific for HLA HC and human β2m.Results: The metalloprotease inhibitor BB9.4 inhibited not only the release of β2m-free HC, but also sHLA/β2m from cells activated with PWM. The concentration of both types of antigen in TCS with BB9.4 was similar to that seen in cultures without PWM stimulation. The molecular weight of both the sHLA/β2m and β2m-free HC was 36kD (i.e. the metalloprotease cleaved form) rather than 44kD (intact form) or 39kD (alternately spliced form). The Western blot analysis also supported the concentrations determined by ELISA as the amount of HLA precipitated from cultures with both PWM and BB9.4 was similar to that precipitated from cultures without PWM and much less than that obtained from cultures stimulated with PWM alone. Conclusions: Activated lymphocytes release 36kD HLA heavy chains via a specific metalloprotease and in the β2m rich environment, like serum, these heavy chains reassociate with β2m to form the typically measured classical 36kD HLA proteins. This data supports the hypothesis that metalloprotease activation during allograft acute and chronic rejection is a limiting step in the generation of soluble HLA proteins.
The spatial and temporal variation of the electron energy distribution function (EEDF) in the HiPIMS discharge (2009)

Summary form only given. We describe measurements of the plasma parameters in a high power impulse magnetron sputtering (HiPIMS) discharge. A Langmuir probe is used to determine the plasma parameters, such as the effective electron temperature T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> , the electron density n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> , the floating potential Va and the plasma potential V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pl</sub> , as well as the electron energy distribution function (EEDF). The spatial and temporal variation of the plasma parameters and the EEDF are recorded in the pressure range 3-20 mTorr. The electron density peaks at 5 x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> for 40-80 mm distance from the target surface for all pressures investigated. The EEDF is more broad for lower discharge pressure. Furthermore, the EEDF becomes narrower as the pulse progresses, which indicates that the plasma cools off, probably due to increased presence of metal species in the discharge. The electron temperature reaches its peak value of 1.5-3 V at 80 microseconds after pulse initiation, in the pressure range 5-20 mTorr.
Satellite Irrigation Management Support With the Terrestrial Observation and Prediction System: A Framework for Integration of Satellite and Surface Observations to Support Improvements in Agricultural Water Resource Management (2012)

In California and other regions vulnerable to water shortages, satellite-derived estimates of key hydrologic fluxes can support agricultural producers and water managers in maximizing the benefits of available water supplies. The Satellite Irrigation Management Support (SIMS) project combines NASA's Terrestrial Observation and Prediction System (TOPS), Landsat and MODIS satellite imagery, and surface sensor networks to map indicators of crop irrigation demand and develop information products to support irrigation management and other water use decisions. TOPS-SIMS provides the computing and data processing systems required to support automated, near real-time integration of observations from satellite and surface sensor networks, and generates data and information in formats that are convenient for agricultural producers, water managers, and other end users. Using the TOPS modeling framework to integrate data from multiple sensor networks in near real-time, SIMS currently maps crop fractional cover, basal crop coefficients, and basal crop evapotranspiration. Map products are generated at 30 m resolution on a daily basis over approximately 4 million ha of California farmland. TOPS-SIMS is a fully operational prototype, and a publicly available beta-version of the web interface is being pilot tested by farmers, irrigation consultants, and water managers in California. Data products are distributed via dynamic web services, which support both visual mapping and time-series queries, to allow users to obtain information on spatial and temporal patterns in crop canopy development and water requirements. TOPS-SIMS is an application framework that demonstrates the value of integrating multi-disciplinary Earth observation systems to provide benefits for water resource management.
Economic evaluation of field bindweed (Convolvulus arvensis) control (1997)

This research compared seven field bindweed control treatments to a check in a 3-yr winter wheat-sorghum-fallow rotation. Treatments included 3 wk intervals of sweep tillage combined with one or two annual applications of 2,4-D (tillage and 2,4-D). Two other treatments were the same as tillage and 2,4-D, except dicamba or a mixture of picloram and 2,4-D were applied once in October after wheat harvest. A fourth treatment was identical to tillage and 2,4-D, except imazapyr was sprayed immediately after harvest of wheat. Also, three no-tillage systems using glyphosate and 2,4-D at monthly intervals were supplemented with either dicamba, picloram and 2,4-D, or imazapyr the same as in treatments involving tillage and 2,4-D. The check was sweep tilled every 6 wk. All treatments controlled field bindweed in one rotation of two fallow periods and two crops. After control was accomplished, wheat and sorghum yields were about twice the check. Using 1995 costs and returns, profit for an owner-operator for the two fallow periods and two crops was $123 ha −1 for tillage and 2,4-D, compared to $19 ha −1 for the check. Tillage and 2,4-D supplemented with picloram or imazapyr were almost as profitable as tillage and 2,4-D. Because of high herbicide cost and low yields, no-tillage treatments lost money. Profits with a 33:67 owner-tenant rental agreement were $105 and $21 ha −1 , respectively, for owner and tenant using tillage and 2,4-D. With no field bindweed control practice, the tenant lost $33 ha −1 and the owner made $51 ha −1 .
EXPERIMENTAL STUDY ON MECHANICAL CHARACTERISTICS OF LARGE SCALE SLIDING SEISMIC ISOLATION BEARING OF TOKYO GATE BRIDGE (2011)

東京ゲートブリッジでは大規模地震に対応するため超大型の機能分離型すべり免震支承を採用した．機能分離型すべり免震支承は鉛直反力を支える鉛直支承と水平反力に抵抗するゴムバッファーの2つの支承部材からなり，鉛直支承のすべり面での摩擦抵抗によりエネルギー減衰を図るものである．ここで，すべり面の摩擦係数が設計上の重要な要素となる．本論文では，すべり面の摩擦係数の面圧依存性，速度依存性等の力学特性をせん断載荷試験により調べた．また，動的応答計算によりこの要因が本橋の地震応答に及ぼす影響を調べるとともに，採用した機能分離型すべり免震支承が設計地震動に対して許容値以内であることを確認した．