gebhart/patrepeval huggingface dataset:
Collaborative virtual environments (2001)

article Share on Collaborative virtual environments Authors: Steve Benford Univ. of Nottingham Univ. of NottinghamView Profile , Chris Greenhalgh Univ. of Nottingham Univ. of NottinghamView Profile , Tom Rodden Univ. of Nottingham Univ. of NottinghamView Profile , James Pycock Cambridge Lab of Xerox Research Centre, Europe Cambridge Lab of Xerox Research Centre, EuropeView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 7July 2001 pp 79–85https://doi.org/10.1145/379300.379322Published:01 July 2001Publication History 220citation5,594DownloadsMetricsTotal Citations220Total Downloads5,594Last 12 Months344Last 6 weeks34 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid (1998)

Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers. As Tf transport through the brain barriers is restricted, Fe is probably released into the brain extracellular compartment as non-Tf-bound iron (NTBI). To evaluate NTBI in the brain and cerebrospinal fluid (CSF), different aged rats (P15, P20, P56) were injected intravenously with [59Fe-125I]Tf followed by sampling of CSF and brain tissue. Between 80 and 93% of 59Fe in CSF was absorbed with anti-Tf and 1 and 5% with anti-ferritin antibodies. The fraction of 59Fe from CSF passing through a 30,000 molecular weight (MW) cutoff filter was approximately 5% (P15), 10% (P20), and 15% (P56). Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded. In the supernatants of brain homogenates, between 94 and 99% of 59Fe was absorbed with anti-Tf and anti-ferritin antibodies. The respective fractions of 59Fe in the supernatants passing through the 30 kD cutoff filter were 4% (P15), 2% (P20), and 6% (P56). In brain homogenates mixed before filtering with desferroxamine (DFO) or nitrilotriacetic acid (NTA) which complex loosely protein-bound Fe and non-protein-bound Fe, these 59Fe fractions were 2-fold higher. The results indicate that NTBI is present extracellularly in CSF and probably in brain interstitium.
Self-reported discrimination and mental health among Asian Indians: Cultural beliefs and coping style as moderators. (2016)

The South Asian (SA) population has been underrepresented in research linking discrimination with health indicators; studies that focus on the unique cultural and psychosocial experiences of different SA subgroups are needed. The purpose of this study was to examine associations between self-reported discrimination and mental health among Asian Indians (AIs), and whether traditional cultural beliefs (believing that South Asian cultural traditions should be practiced in the US), coping style, and social support moderated these relationships. Asian Indians (<i>N</i> = 733) had been recruited from community-based sampling frames for the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study were included in this analysis. Multiple linear regression analyses were employed to evaluate relationships between discrimination and depressive symptoms, anger, and anxiety. Participants (men = 54%) were on average 55 years of age and had high levels of English proficiency, education, and income. Higher reports of discrimination were significantly associated with higher depressive symptoms, B = .27 (.05) <i>p</i> < .001, anger, B = .08 (.01), <i>p</i> < .001, and anxiety, B = .10 (.01), <i>p</i> < .001. Associations between discrimination and anger, B = -.005 (.002), <i>p</i> = .02, were weakest among those with stronger cultural beliefs. The link between discrimination and anxiety was attenuated by an active coping style, B = -.05 (.03), <i>p</i> = .04. In sum, self-reported discrimination appeared to adversely impact the mental health of AIs. Discrimination may be better coped with by having strong traditional cultural beliefs and actively managing experiences of discrimination.
Predictive Immunohistochemical Biomarkers in the Context of Neoadjuvant Therapy for Breast Cancer (2011)

The adoption of personalized medicine has led to the search for prognostic and predictive markers that can be applied to individual patients to give optimal information for their clinical management. We have used samples from randomized clinical trials of hormonal and chemotherapy to identify relevant markers of sensitivity and resistance using a neoadjuvant approach by linking expression of a panel of proteins involved in growth factor receptor signaling, angiogenesis, estrogen receptor signaling, and hypoxia to individual patient response. We evaluated samples from randomized clinical trials of epirubicin with or without tamoxifen, and letrozole with or without metronomic cyclophosphamide, to study chemotherapy, hormonal therapy, and antiangiogenic effects. We present a proof of principle of this approach in identifying several key pathways that are associated with clinical and pathological response. Thus, we have shown that the hypoxia-inducible factor (HIF) pathway, mitogen activated protein kinase, and phosphorylated estrogen receptor-α can identify patients who are likely to respond to hormonal therapy and that HIF signaling is also a marker of resistance for anthracycline-based chemotherapy. To redress the role of HIF, we then evaluated samples from a randomized control trial of an anthracycline chemotherapy with and without erythropoietin. These studies demonstrate that the approach of using primary systemic therapy in breast can identify markers of response and potentially targets for rationale design of new therapies.
Particle size distribution in mini-emulsion polymerization (2003)

The particle size distribution polydispersities of a number of macro- and mini-emulsion latexes are reported. In cases where the macro-emulsion and mini-emulsions were produced under very nearly identical conditions, the mini-emulsion will have a polydispersity equal to, or only very slightly greater than, the equivalent macro-emulsion.
Research on the characteristics of flexible antennas for general applications (2008)

In this paper, flexible inverted-F antennas (FIFA) printed on flexible substrate are presented for 2.4 GHz ISM band operation. The characteristics of the antennas in the form of flat and bend are studied first. Secondly, to reduce the negative effect caused by nearby objects on the performance of the antenna, the antenna is redesigned by adding a ferrite layer at the bottom of the flexible substrate. It is found that the ferrite material makes the redesigned antenna possible to be used under general environments or conditions.
Catalytic alkyl group exchange reaction of primary and secondary amines (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic alkyl group exchange reaction of primary and secondary aminesShunichi Murahashi, Noriaki Yoshimura, Tatsuo Tsumiyama, and Takeyuki KojimaCite this: J. Am. Chem. Soc. 1983, 105, 15, 5002–5011Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00353a025https://doi.org/10.1021/ja00353a025research-articleACS PublicationsRequest reuse permissionsArticle Views2598Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Establishment of a new cell line, VA-N-BR, from a primitive neuroblastoma tumor of the abdomen. (1992)

An established cell line was derived from a neuroblastoma originating in the abdomen of a six year old male. This patient had increased urinary homovanillic acid on two occasions, and the tumor had a unique pattern of local peritoneal and hepatic dissemination but not distant spread. The cells were initially highly refractile round cells forming firmly adherent cell clumps which later formed irregularly shaped bodies with mono- or bipolar short processes attached to the plastic surface of the culture flask. Chromosomal tetraploidy and marker chromosomes distinguished these cells from Ewings sarcoma, neuroepithelioma and the common disseminating neuroblastoma. Immunohistochemical staining positive for neurofilament, chromogranin, desmin and vimentin suggested it to be relatively undifferentiated. When heterotransplanted to nude mice, these cells expressed only desmin and vimentin reactivity. This neuroblastoma cell line was established and designated as VA-N-BR. It appears to be different from the more common partially differentiated neuroblastoma of childhood.
Long Term Efficacy of Rituximab in B-Cell Post Transplantation Lymphoproliferative Disorders (B-PTLD): Update of the Multicenter, Open Label, Phase II Trial (M39037 TRIAL). (2006)

Abstract Background: B-PTLD is a rare but severe complication observed after organ transplantation. There is no consensus on treatment modalities in this setting but Rituximab monotherapy has been presented as an effective and well tolerated treatment. Long term efficacy is unknown. Aim: We recently published results of the first prospective study on PTLD treatment, using four weekly injection of Rituximab in progressive or non responding tumours after immunosuppression diminution (Blood2006; 107; 3053–7). We present here update results up to 6 years after inclusion. Methods: From may 2000 to December 2001, 43 PTLD after solid organ transplantation have been enrolled in M39037, a franco-belgian multicentric prospective trial. The primary end point was day 80 response rate and one year results were also presented. Participating centres were contacted in order to obtain update data on surviving patients at one year, especially for their tumour status (complete response (CR), partial response (PR) or progressive disease (PD)), date of last information, eventual death and cause of death. Results: At one year, on 43 included patients, 26 were still alive, 12 in CR or Cru, one in PR, 10 in PD and two with insufficient information. At this time, update data are available on eight patients, six were in CR or Cru at one year and two in PD. Five patients died by organ failure (n=1), graft rejection (n=1), sudden death (n=2) or heart biopsy complication (n=1); all but one were in CR at this time. Three patients are still alive and in CR. No relapse has been diagnosed and median survival is 1188 days (with a median follow up of 1689 days for surviving patients). Final analysis on all patients will be presented at the ASH meeting. Conclusion: Rituximab in monotherapy seems to have a durable efficacy on PTLD after solid organ transplantation with a follow up of more than 4,5 years. Complete results will be presented at the ASH Meeting.
Migraine headaches in Chronic Fatigue Syndrome (CFS): Comparison of two prospective cross-sectional studies (2011)

Georgetown University IRB # 2006-481
A traffic model for networked devices in the building automation (2004)

Traffic models play a decisive part in the performance evaluation and design of communications systems. However, the growing diversification of devices in large networks asks for automated generated traffic models. In this paper, we present a generic device model which is suited for automated generation in the domain of building automation. The traffic is deduced successive for common devices from measurements and simulations using classification of the devices by their traffic behaviour and automated parameterization of the device models
Chromosome 15q13.3 microduplications are associated with treatment refractory major depressive disorder (2019)

Major depressive disorder (MDD) affects approximately 15 million Americans. Approximately 2 million of these are classified as being refractory to treatment (TR-MDD). Because of the lack of available therapies for TR-MDD, and the high risk of suicide, there is interest in identifying new treatment modalities and diagnostic methods. Understanding of the impact of genomic copy number variation in the etiology of a variety of neuropsychiatric phenotypes is increasing. Low copy repeat elements at 15q13.3 facilitate non-allelic homologous recombination, resulting in recurrent copy number variants (CNVs). Numerous reports have described association between microdeletions in this region and a variety of neuropsychiatric phenotypes, with CHRNA7 implicated as a candidate gene. However, the pathogenicity of 15q13.3 duplications is less clear. As part of an ongoing study, in which we have identified a number of metabolomic anomalies in spinal fluid from TR-MDD patients, we also evaluated genomic copy number variation in patients (n = 125) and controls (n = 26) via array-based copy number genomic hybridization (CGH); the case frequency was compared with frequencies reported in a prior study as well as a larger population-sized cohort. We identified five TR-MDD patients with microduplications involving CHRNA7. CHRNA7 duplications are the most common CNVs identified by clinical CGH in this cohort. Therefore, this study provides insight into the potential involvement of CHRNA7 duplications in the etiology of TR-MDD and informs those involved with care of affected individuals.
Effect of Patient Personality Profile and Verbal Presentation on Successful Rigid Contact Lens Adaptation, Satisfaction and Compliance (1998)

It was concluded that the method of presentation is important for successful RGP contact lens wear. If presented with genuine interest and a positive and realistic attitude, patients are more likely to succeed in RGP lens wear during the initial critical period.
OFDM for Next-Generation Optical Access Networks (2011)

In this tutorial overview, the principles, advantages, challenges, and practical requirements of optical orthogonal frequency division multiplexing (OFDM)-based optical access are presented, with an emphasis on orthogonal frequency division multiple access (OFDMA) for application in next-generation passive optical networks (PON). General OFDM principles, including orthogonality, cyclic prefix use, frequency-domain equalization, and multiuser OFDMA are summarized, followed by an overview of various optical OFDM(A) transceiver architectures for next-generation PON. Functional requirements are outlined for high-speed digital signal processors (DSP) and data converters in OFDMA-PON. A techno-economic outlook for such a “software-defined,” DSP-based optical access platform is also provided.
Online multicast routing with bandwidth guarantees: A new approach using multicast network flow (2003)

We present a new algorithm for online routing of bandwidth-guaranteed multicasts where routing requests arrive one by one without any prior knowledge of future requests. A multicast routing request consists of a source, a set of receivers, and a bandwidth requirement. Two multicast applications of interest are routing of point-to-multipoint label-switched paths in multiprotocol label switched (MPLS) networks, and the provision of bandwidth-guaranteed virtual private network (VPN) services under the "hose" service model. Without prior knowledge of multicast requests, offline multicast routing algorithms cannot be used. Online algorithms are needed to handle requests arriving one by one and to satisfy as many potential future demands as possible. Our new online algorithm is based on the idea that a newly routed multicast must follow a route that does not interfere too much with network paths that may be critical to satisfy future demands. We develop a multicast tree selection heuristic based on the idea of deferred loading of certain critical links. The algorithm identifies them as links that, if heavily loaded, would make it impossible to satisfy future demands between certain ingress-egress pairs. The algorithm uses link-state information and some auxiliary capacity information for multicast tree selection and is amenable to distributed implementation. Unlike previous algorithms, our algorithm exploits any available knowledge of the network ingress-egress points of potential future demands, even though the demands themselves are unknown. It performs very well.
Tryptophan 32 Potentiates Aggregation and Cytotoxicity of a Copper/Zinc Superoxide Dismutase Mutant Associated with Familial Amyotrophic Lateral Sclerosis (2007)

One familial form of the neurodegenerative disease, amyotrophic lateral sclerosis, is caused by gain-of-function mutations in the gene encoding copper/zinc superoxide dismutase (SOD-1). This study provides in vivo evidence that normally occurring oxidative modification to SOD-1 promotes aggregation and toxicity of mutant proteins. The oxidation of Trp-32 was identified as a normal modification being present in both wild-type enzyme and SOD-1 with the disease-causing mutation, G93A, isolated from erythrocytes. Mutating Trp-32 to a residue with a slower rate of oxidative modification, phenylalanine, decreased both the cytotoxicity of mutant SOD-1 and its propensity to form cytoplasmic inclusions in motor neurons of dissociated mouse spinal cord cultures.
Antimicrobial effects of airborne acoustic ultrasound and plasma activated water from cold and thermal plasma systems on biofilms (2020)

Bacterial biofilms are difficult to inactivate due to their high antimicrobial resistance. Therefore, new approaches are required for more effective bacterial biofilm inactivation. Airborne acoustic ultrasound improves bactericidal or bacteriostatic activity which is safe and environmentally friendly. While, plasma activated water (PAW) is attracting increasing attention due to its strong antimicrobial properties. This study determined efficacy of combined airborne acoustic ultrasound and plasma activated water from both cold and thermal plasma systems in inactivating Escherichia coli K12 biofilms. The application of airborne acoustic ultrasound (15 min) alone was significantly more effective in reducing E. coli counts in 48 and 72 h biofilms compared to 30 min treatment with PAW. The effect of airborne acoustic ultrasound was more pronounced when used in combination with PAW. Airborne acoustic ultrasound treatment for 15 min of the E. coli biofilm followed by treatment with PAW significantly reduced the bacterial count by 2.2-2.62 Log<sub>10</sub> CFU/mL when compared to control biofilm treated with distilled water. This study demonstrates that the synergistic effects of airborne acoustic ultrasound and PAW for enhanced antimicrobial effects. These technologies have the potential to prevent and control biofilm formation in food and bio-medical applications.
Intelligent Decision Support and Fusion Models for Fault Detection and Location in Power Grids (2021)

Computational intelligence-based diagnostic frameworks have emerged as rapidly evolving but highly efficient approaches for diagnosing faults in power grids. This work aims to build a diagnostic framework by resorting to computational intelligence techniques to improve decision-making and diagnostic accuracy. This diagnostic framework has three modules for signal processing, fault detection, and location. The signal-processing module uses the variational mode decomposition technique to extract informative time-frequency features from the voltage and frequency signals. Voltage features are then fed into the fault detection module to train a set of modular support vector machines that are used for monitoring the binary state of each node in the power grid. Once a faulty state on a node is detected, it activates the third module for identifying fault location. This module benefits from a novel zSlices-based general type-2 fuzzy fusion model for the sake of identifying the fault type as well as mitigating the false alarm rate. The exact location of the fault is then determined through a fuzzy decision support system that is equipped with a recommendation mechanism for the sake of consensus reaching. Various scenarios are simulated on the IEEE 39-bus system and on an experimental setup of a Three-Bus Two-Line transmission system, where the attained results verify the applicability, efficiency, and robustness of the proposed framework.
Notes: Lactobacillus oris sp. nov. from the Human Oral Cavity (1988)

Nucleic acid and biochemical studies were performed on some lactobacilli from the human oral cavity which phenotypically resemble Lactobacillus brevis. The oral strains were distinct from L. brevis and other heterofermentative Lactobacillus species and warrant a new species, for which the name Lactobacillus oris sp. nov. is proposed. The type strain of Lactobacillus oris is NCDO 2160T.
Particle–particle interaction effects in image projection lithography systems (1993)

Using commercially available software (Discrete Coulomb Interactions Software from Munro’s Electron Beam Software Ltd.) we have investigated image broadening as a result of stochastic interactions for projection systems. We have derived empirically, design constraints applicable to ion and electron projection systems and used them to analyze system designs suggested in the literature. We conclude that for many of the suggested designs stochastic interactions will prevent useful throughputs from being achieved. Finally, we discuss system design approaches which are necessary for a successful high-throughput, high-resolution image projection lithography system.