gebhart/patrepeval huggingface dataset:
Expression of P2X receptors on rat microglial cells during early development (2005)

We have used single- and double-labeling immunfluorescence and reverse transcription-polymerase chain reaction (RT-PCR) methods to examine expression of P2X receptor subtypes on microglial cells of brain in late embryonic and postnatal rat, in the N9 microglial cell line and primary cultured microglial cells. P2X1, P2X4, and P2X7 receptors were shown on microglial cells from late embryonic day 16. Almost all the microglial cells that were positive for the marker ED1, expressed P2X1 and P2X4 receptors, whereas only about 30% of the cells with ED1-immunoreactivity were found to express the P2X7 receptor. Positive cells were localized mainly in the white matter and around ventricles. From postnatal day 7, many microglial cells with P2X4 receptor-immunoreactivity were seen around the blood vessels. At postnatal day 30, microglial cells with P2X1 receptor-immunoreactivity disappeared and the cells with P2X4 receptor-immunoreactivity were mainly localized around blood vessels and lining the subarachnoid space. From postnatal day 30, the microglial cells with P2X7 receptor-immunoreactivity were found to be distributed widely in the forebrain. Cells with P2X7 receptor-immunoreactivity from P30 were not labeled by ED1, but some were labeled by isolectin B4. The expression of P2X1, P2X4, and P2X7 receptor mRNA and protein on primary cultures of rat microglial cells and on the N9 microglial cell line was demonstrated with immunocytochemistry and RT-PCR. This is the first report that the P2X1 receptor is expressed on microglial cells, at least in early development, before postnatal day 30.
Changes in the Essential Oil Components during the Development of Fennel Plants from Somatic Embryoids (1987)

Quantitative and qualitative changes of essential oils during the development of clonal plants of fennel propagated through somatic embryogenesis were investigated. Although no essential oil could be detected either in cultured cells or in somatic embryoids, monoter-penes such as alpha-phellandrene and alpha-pinene were found in radical leaves of regenerated plantlets cultured on a hormone-free agar medium. The regenerated plants cultivated in the field for about one month accumulated phenylpropanoids such as estragole, anethole, and fenchone in addition to the two monoterpenes described above in radical leaves. Rich accumulations of phenylpropanoids and monoterpenes were observed in the fruits; especially the contents of estragole and anethole were much higher than in radical leaves.
[Immunologic characteristics of a polyvalent vaccine]. (1989)

A lot of bacterial vaccines show a very interesting immunostimulating profile. The AA. studied the effects of a polyvalent vaccine on the phagocytosis, on the cellular immunity and on the IgA production. They also investigated its capacity to reactivate the response to the C tetani toxin (Booster effect), both "in vitro" and in human volunteers. The results show a significant improvement in the immunity response to specific and aspecific stimuli.
Use of a percutaneous vascular suture device for closure of an inadvertent subclavian artery puncture (2003)

A well-known complication of central venous catheterization is inadvertent arterial sheath placement. Sheath removal from noncompressible arteries has the potential for severe complications. We report a case of inadvertent subclavian arterial sheath placement during an attempted internal jugular venous catheterization. This was successfully removed using a percutaneous vascular suture device.
Accuracy of behavioural threshold prediction using steady-state evoked potentials [Abstract] (1994)

This is a publisher’s version of an article published in Australian Journal of Audiology 1994. This version is reproduced with permission from the publisher, Australian Academic Press. http://www.australianacademicpress.com.au/
Association between the type of thyroid dysfunction induced by immune checkpoint inhibitors and prognosis in cancer patients (2021)

Abstract Background Immune checkpoint inhibitors (ICIs) cause thyroid immune-related adverse effects (irAEs). However, associations between each type of thyroid immune-related adverse effect (irAE) and the anti-tumor effect of ICI remains unknown. This study aimed to determine the effects of each type of thyroid dysfunction on patient survival. Methods Patients who initiated ICI treatment from January 2015 to December 2019 in Seoul St. Mary’s Hospital were retrospectively analyzed. Thyroid dysfunction was classified into four types: newly developed overt or subclinical hypothyroidism, thyrotoxicosis, worsened hypothyroidism, and subclinical hyperthyroidism. Patients were divided into two groups according to the presence or absence of thyroid dysfunction. Results Among the 196 patients, 66 (33.7%) developed thyroid irAEs. There was no significant difference in age, sex, or cancer type between the two groups. The overall survival in patients with thyroid irAEs was significantly higher than that in patients without thyroid irAEs (38 months vs. 13 months, respectively, p = 0.005). After adjusting for confounding factors, the hazard ratio for mortality in the thyroid irAE group compared to the no thyroid irAE group was 0.520 (p = 0.007). Newly developed overt or subclinical hypothyroidism patients showed a significantly lower hazard ratio for morbidity of 0.309 (p = 0.001). Patients with thyrotoxicosis showed a worse hazard ratio for morbidity than those without thyroid irAE, although the difference was not statistically significant. Conclusions It was verified that ICI treatment-induced thyroid dysfunction was associated with better survival, even in the real-world practice. Thus, endocrinologists should cooperate with oncologists to monitor patients treated with ICIs.
Engineering inorganic interfaces using molecular nanolayers (2023)

Advances in interface science over the last 20 years have demonstrated the use of molecular nanolayers (MNLs) at inorganic interfaces to access emergent phenomena and enhance a variety of interfacial properties. Here, we capture important aspects of how a MNL can induce multifold enhancements and tune multiple interfacial properties, including chemical stability, fracture energy, thermal and electrical transport, and electronic structure. Key challenges that need to be addressed for the maturation of this emerging field are described and discussed. MNL-induced interfacial engineering has opened up attractive opportunities for designing organic–inorganic hybrid nanomaterials with high interface fractions, where properties are determined predominantly by MNL-induced interfacial effects for applications.
Modeling the XPS Si 2p core‐level intensities of silicon nanocrystals for determination of oxide shell thickness (2006)

Abstract We have developed a simplified model of the core and oxide shell XPS intensities of 5‐nm diameter Si nanocrystals for determining the shell thickness. The model is based on a cylindrical shape of the nanocrystals that allows the use of Himpsel's model for planar Si oxidation, and takes into account different escape depths for photoelectrons emitted by the core and the shell. The experimental core/shell intensity ratio is obtained from high‐resolution XPS spectra recorded with synchrotron radiation (photon energy 320 eV). The resulting calculated shell thickness is found to vary over the 0.74–1.32 nm range in a consistent way, according to the surface treatment performed on the nanocrystals. Copyright © 2006 John Wiley &amp; Sons, Ltd.
Mechanisms of Photochemical Reactions in Solution. XVI.1 Photosensitized Dimerization of Conjugated Dienes (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of Photochemical Reactions in Solution. XVI.1 Photosensitized Dimerization of Conjugated DienesGeorge S. Hammond, Nicholas J. Turro, and Robert S. H. LiuCite this: J. Org. Chem. 1963, 28, 12, 3297–3303Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://doi.org/10.1021/jo01047a005RIGHTS & PERMISSIONSArticle Views426Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (929 KB) Get e-Alertsclose Get e-Alerts
Novel Digital Equalizer for XPM-induced Polarization Crosstalk using Overlapped Fast Independent Component Analysis (2013)

A novel equalization algorithm using overlapped fast independent component analysis (FastICA) is proposed and investigated for nonlinear polarization crosstalk (NPC). The algorithm is shown to provide better Q-factor improvement than conventional algorithms. Also shown are its advantages when used in the step prior to other DSP procedures.
P1‐111: Progress towards a neuronal cell model of the tauopathies (2010)

Mutations in the gene encoding the microtubule associated protein tau (MAPT) cause frontotemporal dementia (FTD). Alternative splicing of MAPT generates six distinct tau isoforms in the adult human CNS, where its major function is to stabilise the microtubule cytoskeleton. MAPT mutations cause either aberrant splicing or amino acid changes which reduce the ability of tau to bind microtubules. The complex pattern of tau splicing is not recapitulated in current cell models making it difficult to elucidate the mechanisms by which tau splice mutations lead to neuronal cell death. We aim to generate induced pluripotent stem (iPS) cells from fibroblasts taken from patients harbouring MAPT mutations. We will differentiate embryonic stem (ES) and iPS cells into neurons and evaluate them as a model of human tau splicing in order to investigate the effect of tau coding and splice mutations on neuronal viability. Patients carrying mutations in MAPT were identified in cognitive disorders clinics at the National Hospital for Neurology and Neurosurgery and University Hospital Wales. Primary fibroblast lines were generated from skin-punch biopsy samples using standard techniques. To generate iPS cells, fibroblasts were infected with OCT4, SOX2, KLF4 and MYC retroviruses. iPS clones were picked on the basis of morphology for expansion and further characterisation. Patient-specific iPS cells have been generated and are currently undergoing validation. Successful reprogramming was judged by morphology and expression of pluripotency -associated markers. Ongoing work aims to apply this technique to a larger cohort of patient samples. We are also differentiating ES and iPS cells into neurons to examine tau isoform expression. ES and iPS cell-derived neurons provide a novel cell model for the study of tau splicing and the affects of coding and splice-site tau mutations on neuronal viability.
Optical Beam Phase Conjugation By Stimulated Backscattering (1982)

We review the history and nature of stimulated scattering of optical beams and of the large phase-conjugate component often observed in stimulated backscattering, whether it be of Raman, Brillouin, Rayleigh, or other origin. We review the theory of the magnitude of the phase-conjugate component in stimulated backscattering of waves in a multimode optical guide (the usual experimental configuration) or in free focus. Wide applicability of stimulated backscattering for optical phase conjugation is found.
Nonexercise Models for Estimating VO2max with Waist Girth, Percent Fat, or BMI (2006)

Waist girth is an acceptable surrogate for body composition in the nonexercise models. All models were similar in accuracy and valid for estimating VO2max of most adults, but with reduced accuracy at the extremes of fitness (VO2max < 30 and >50 mL x kg(-1) x min(-1)).
Modification and Characterization of Metallized Tips for Scanning Probe Microscopy (2007)

Abstract The characterization of nanoscale regions in present and future device structures of leading-edge microelectronic products requires probes with dedicated features tailored on the nanoscale. SPM tips are used not only for conventional AFM characterization, but also for electrical, thermal and optical investigation of devices. For particular applications as nano-Raman spectroscopy or conductive AFM, highly reproducible metal tips or metallized tips are needed. In this paper, new approaches to tailor those tips using the FIB technique, and to characterize the tips using dedicated structures and adapted AFM methods are described. Based on a numerical procedure, the tip quality is described quantitatively. The described preparation and calibration techniques offer new possibilities for the routine application of nanostructures and nanodevices as needed for advanced SPM techniques and nanosensors.
Strange Stable Replicators Generated From Mumps Virus cDNA Clones (2018)

Abstract In reverse genetic experiments we have isolated recombinant mumps viruses (rMuV) based on a recent clinical isolate that carry large numbers of mutations clustered in small parts of their genome and which are not caused by biased hyper-mutation. In two separate experiments we obtained such rMuV: one virus had 19 mutations in the V/P region of the genome; the other, which also contained an extra transcription unit encoding green fluorescent protein (EGFP), had 32 mutations in the N gene. These specific constellations of mutations have not been observed in naturally occurring MuV isolates. The vast majority of the mutations (48/51) are synonymous. On passage in Vero cells and human B-LCL cells, a B lymphocyte-like cell Line, these mutations appear stable as no reversal occurs to the original consensus sequences, though mutations in other genes occur and change in frequency during passage. Defective Interfering RNAs accumulate in passage in Vero cells but not in B-LCL cells. Interestingly, in all passaged samples the level of variation in the EGFP gene is the same as in the viral genes, though it is unlikely that this gene is under any functionality constraint. The stability in repeated high multiplicity passage indicates that the constellation of mutations is placing the virus on a fitness peak from which it cannot escape. What mechanism gave rise to these mutant viruses and their stability remain open questions of interest to a wider field than mumps reverse genetics alone.
Spectroscopic and Structural Characterization of Water-Shared Ion-Pairs in Aqueous Sodium and Lithium Hydroxide (2021)

The structures of the ion-pairs formed in aqueous NaOH and LiOH solutions are elucidated by combining Raman multivariate curve resolution (Raman-MCR) experiments and <i>ab initio</i> molecular dynamics (AIMD) simulations. The results extend prior findings to reveal that the initially formed ion-pairs are predominantly water-shared, with the hydroxide ion retaining its full first hydration-shell, while direct contact ion-pairing only becomes significant at higher concentrations. Our results confirm previous experiments and simulations indicating greater ion-pairing in aqueous LiOH than NaOH as well as at high temperatures. Our results further imply that NaOH and LiOH ion-pairing free energies have an approximately linear (rather than square-root) dependence on ion concentration (in the molar range), with positive enthalpies and entropies that increase with concentration, thus implying that water-mediated interactions enthalpically disfavor and entropically favor ion-pair formation.
AI-Generated Virtual Instructors Based on Liked or Admired People Can Improve Motivation and Foster Positive Emotions for Learning (2022)

This paper presents the results of a study with 134 participants to explore the effects of learning from an AI-generated virtual instructor that resembles a person one likes or admires. Given the important role instructors play in shaping learning experiences, as well as the recent surge in demand for online education, we investigate the potential for AI-generated instructors to motivate learning. Recent advances in generative AI have made it easy to create virtual instructors based on the likeness of a present-day, historical or fictional person, thereby enabling customization of video instructors based on the material, context and student. We found that while greater degrees of liking and admiration do not result in increased test scores, they can significantly improve students’ motivation towards learning, foster more positive emotions, and boost their appraisal of the AI-generated instructor as serving as an effective instructor.
Sulfones from sodium benzenesulfinate (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfones from sodium benzenesulfinateJoel M. KauffmanCite this: J. Chem. Eng. Data 1969, 14, 4, 498–499Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://pubs.acs.org/doi/10.1021/je60043a007https://doi.org/10.1021/je60043a007research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DIAGNOSIS OF REYE SYNDROME (1976)

Three patients with acute encephalopathy and evidences of liver damage are presented. One of them was diagnosed as having Reye syndrome on the basis of light microscopic and electron microscopic observations on liver histology as well as clinical and laboratory evidences. Other 2 patients had liver histology different from that seen in Reye syndrome, despite they had clinical features and laboratory findings which were very similar to those of Reye syndrome. We propose from these experiences that diagnosis of Reye syndrome can only be made with histological evidence. Studies on the pathophysiology of other 2 patients who showed very similar metabolic alterations may given an alternative way to reach the essential pathogenesis of Reye syndrome, which may provide us with the possibility of nonhistologic diagnosis of Reye syndrome.
Undoing actions in collaborative work (1992)

Article Free Access Share on Undoing actions in collaborative work Authors: Atul Prakash View Profile , Michael J. Knister View Profile Authors Info & Claims CSCW '92: Proceedings of the 1992 ACM conference on Computer-supported cooperative workDecember 1992 Pages 273–280https://doi.org/10.1145/143457.143527Published:01 December 1992Publication History 36citation502DownloadsMetricsTotal Citations36Total Downloads502Last 12 Months12Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Investigation of surface water quality in magnitogorsk industrial area for the environmental estimation of technogenic watercourse state (2017)

It was established that the average chemical indicators of water (ml/l) were as follows: 760 for mineralization, 73 for chlorides, 54 for sulfates, and water pH was not more than 8. Taking into account the indicators of the groundwater quality in this area, it can be said that the general pollution resistance of natural waters is low.The main indicators characterizing quality and use of water from this source were considered. Coming of industrial effluents from ore mining and processing facilities and metallurgical production of the integrated metallurgical plant has led to a significant change in the physicochemical parameters of the aquatic environment, which limits this water use.In general, the irrigation indices calculated in this work comply with the norms. However within the city limits (pond-cooler), water is characterized by an elevated pH (&gt;8), which is already a limitation for the use of pond water for irrigation. It should be noted that water containing CO2&gt;1.5 mg-equ./l and pH&gt;8.4 has limitations for irrigation of crops.The obtained data are important for the use of water for the needs of population and the city-forming Magnitogorsk Metallurgical Works PJSC.
Automatic Classification of Cardiac Views in Echocardiogram Using Histogram and Statistical Features (2015)

Automatic classification cardiac views is the first step to automate wall motion analysis, computer aided disease diagnosis, measurement computation etc. In this paper a fully automatic classification of cardiac view in echocardiogram is proposed. The system is built based on a machine learning approach which characterizes two features 1) Histogram features and 2) Statistical features. In this system four standard views parasternal short axis (PSAX), parasternal long axis (PLAX), apical two chamber (A2C) and apical four chamber (A4C) views are classified. Experiments over 200 echocardiogram images show that the proposed method with an accuracy of 87.5% can be effectively used in cardiac view classification.