gebhart/patrepeval huggingface dataset:
Massive Twinning to Enhance Emergent Intelligence (2022)

As a complement to conventional AI solutions, emergent intelligence (EI) exhibits competitiveness in 6G IIoT scenario for its various outstanding features including robustness, protection to privacy, and scalability. However, despite the low computational complexity, EI is challenged by its high demand of data traffic in massive deployment. We propose to leverage massive twinning, which 6G is envisaged to support, to reduce the data traffic in EI and therewith enhance its performance.
Production of lymphotoxin, IFN-gamma and IFN-alpha, beta by murine T cell lines and clones. (1983)

The PCl-6 T cell line, derived from mice sensitized by skin painting with picryl chloride (PCl), shows antigen dependence for DNA synthesis and for lymphotoxin (LT) production. These cells produce LT, but not interferon (IFN), when exposed to 2,4,6-trinitrobenzene sulfonic acid- (TNBS) coupled syngeneic spleen cells. Concanavalin A (Con A) induces IFN production by PCl-6 cells, and IFN levels, but not LT titers, are increased by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). These results support the noncoordinate regulation of these two lymphokines. Line 32, a T cell growth factor- (TCGF) dependent T cell line and its Ly-1.2+, 2.2- derivative clone, 32H1, produce both antiviral and antiproliferative activity after exposure to several different mitogens. Tests for acid lability, sensitivity to anti-mouse IFN-alpha, beta antisera, and antiproliferative activity on non-mouse target cells indicates that an Ly-1+ clone, in the absence of both TCGF and accessory cells, can produce at least three separate lymphokine activities after Con A exposure: IFN-gamma (Type II), IFN-alpha, beta (Type I), and LT.
A Novel HARQ Using Grouping and Encoding Technique (2009)

In this paper, a novel HARQ scheme is proposed by grouping the information bit portion from failed packet and the new information bit portion from new transmit packet, and then both portions are encoded by CRC and turbo code. In the reception, both bit portions are jointly decoded to obtain grouped HARQ coding gain. System level simulation demonstrates that grouping based HARQ achieves 15% sector throughput gain as opposed to conventional Chase-combining HARQ by slightly suffering transmit latency and only adding an ACK/NAK bit.
Synthesis and Characterization of C-TiO2 Nanomaterials Via Carbon Assistance Method (2018)

Background: With the increasing serious problem of water environment pollution, it is a hot spot to study the high efficient sewage treatment method. Owning to the photosensitization of carbon nanomaterials, carbon doped TiO2 (C-TiO2) has higher photocatalytic activity. Method: Here, we proposed a new method, carbon-assisted method, to prepare C-TiO2 nanomaterials. We first used degreasing cotton as a dispersant to fully absorb the TiCl4 sol. Results: After high-temperature calcination, C-TiO2nanomaterials were obtained. Characterizations results showed that the high specific surface area C-TiO2 nanomaterials in the size of about 50 nm showed a broader light absorption and narrower bandgap spectrum than P25 (commercial TiO2 nanoparticles). Conclusion: The C-TiO2 nanomaterials showed stronger photocatalytic ability than P25.
Thyroid nodule ultrasound: which indication for FNA? a prospective study (2016)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Fast and Reliable Dispersal of Crash-Prone Agents on Graphs. (2019)

We study the ability of mobile agents performing simple local computations to completely cover an unknown graph environment while implicitly constructing a distributed spanning tree. Whenever an agent moves, it may crash and disappear from the environment. The agents activate autonomously at exponential waiting times of mean $1$ and enter the graph over time at a source vertex $s$. They are able to settle at vertices of the graph and mark a neighbour. The agents are identical and make decisions driven by the same local rule of behaviour. The local rule is only based on the presence of neighbouring agents, and whether a neighbour marks the agent's current location. 
An implicit spanning tree is gradually constructed by having certain agents settle and act as its vertices, marking their parent. Each vertex in the environment has limited physical space and may contain at most a settled and an unsettled agent. Our goal is to show that even under conditions of asynchronicity, frequent crashing, and limited physical space, the simple mobile agents successfully cover the environment and construct a distributed spanning tree in linear time. Specifically, we show that, assuming at most $ct/4$ crashes happen before time $t$ for all times $t$, the agents can complete the tree asymptotically almost surely in $8\big((1-c)^{-1}+o(1)\big)n$ time where $n$ is the number of vertices. The analysis relates our algorithm to the ``totally asymmetric simple exclusion process'' in statistical mechanics.
Blood microsampling from the ear capillary in non-human primates (2015)

Blood sampling from awake non-human primates (NHPs) is classically performed under constraint in the cephalic or saphenous vein. It is a challenging, potentially harmful and stressful procedure which may lead to biased results and raises ethical concerns. Laboratory NHPs undergo a head-restrained procedure allowing for a safer procedure of collecting blood from their ears. Using regular capillary blood collection devices 500 µL of blood can be easily withdrawn per puncture point, which is sufficient for performing most of the usual modern biological assays. This procedure has been validated by measuring total proteins, cortisol and vasopressin concentrations from concomitant blood samples taken from the saphenous vein and the ear capillary vessels of macaques (n = 16). We observed strong correlations between the blood concentrations of total proteins, cortisol and vasopressin (r = 0.72, r = 0.63, r = 0.83, respectively; all P values <0.01) taken from the saphenous vein and from the ear capillary. There were no significant differences between blood concentrations taken from the saphenous vein and the ear capillary. Our alternative to the classical blood collection procedure is harmless and can be routinely performed, which can therefore improve scientific results while increasing animal welfare in accordance with the 3R (replacement, reduction and refinement) principles.
Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro (2010)

Lipopolysaccharide exerts many effects on many cell lines, including cytokine secretion, and cell apoptosis and necrosis. We investigated the in vitro effects of lipopolysaccharide on apoptosis of cultured human dental pulp cells and the expression of Bcl-2 and Bax. Dental pulp cells showed morphologies typical of apoptosis after exposure to lipopolysaccharide. Flow cytometry showed that the rate of apoptosis of human dental pulp cells increased with increasing lipopolysaccharide concentration. Compared with controls, lipopolysaccharide promoted pulp cell apoptosis (P < 0.05) from 0.1 to 100 μg/mL but not at 0.01 μg/mL. Cell apoptosis was statistically higher after exposure to lipopolysaccharide for 3 days compared with 1 day, but no difference was observed between 3 and 5 days. Immunohistochemistry showed that expression of Bax and Bcl-2 was enhanced by lipopolysaccharide at high concentrations, but no evident expression was observed at low concentrations (0.01 and 0.1 μg/mL) or in the control groups. In conclusion, lipopolysaccharide induced dental pulp cell apoptosis in a dose-dependent manner, but apoptosis did not increase with treatment duration. The expression of the apoptosis regulatory proteins Bax and Bcl-2 was also up-regulated in pulp cells after exposure to a high concentration of lipopolysaccharide.
Snorkel (2017)

Labeling training data is increasingly the largest bottleneck in deploying machine learning systems. We present Snorkel, a first-of-its-kind system that enables users to train state-of- the-art models without hand labeling any training data. Instead, users write labeling functions that express arbitrary heuristics, which can have unknown accuracies and correlations. Snorkel denoises their outputs without access to ground truth by incorporating the first end-to-end implementation of our recently proposed machine learning paradigm, data programming. We present a flexible interface layer for writing labeling functions based on our experience over the past year collaborating with companies, agencies, and research labs. In a user study, subject matter experts build models 2.8× faster and increase predictive performance an average 45.5% versus seven hours of hand labeling. We study the modeling tradeoffs in this new setting and propose an optimizer for automating tradeoff decisions that gives up to 1.8× speedup per pipeline execution. In two collaborations, with the U.S. Department of Veterans Affairs and the U.S. Food and Drug Administration, and on four open-source text and image data sets representative of other deployments, Snorkel provides 132% average improvements to predictive performance over prior heuristic approaches and comes within an average 3.60% of the predictive performance of large hand-curated training sets.
Directed evolution strategies for improved enzymatic performance (2005)

The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic evolution on a laboratory timescale, is now well established. However, the general acceptance of these methods as a route to new biocatalysts for organic synthesis requires further improvement of the methods for both ease-of-use and also for obtaining more significant changes in enzyme properties than is currently possible. Recent advances in library design, and methods of random mutagenesis, combined with new screening and selection tools, continue to push forward the potential of directed evolution. For example, protein engineers are now beginning to apply the vast body of knowledge and understanding of protein structure and function, to the design of focussed directed evolution libraries, with striking results compared to the previously favoured random mutagenesis and recombination of entire genes. Significant progress in computational design techniques which mimic the experimental process of library screening is also now enabling searches of much greater regions of sequence-space for those catalytic reactions that are broadly understood and, therefore, possible to model. Biocatalysis for organic synthesis frequently makes use of whole-cells, in addition to isolated enzymes, either for a single reaction or for transformations via entire metabolic pathways. As many new whole-cell biocatalysts are being developed by metabolic engineering, the potential of directed evolution to improve these initial designs is also beginning to be realised.
Addition anionischer Lewis‐Basen an Arsinidenkomplexe (1981)

Abstract Der Chlorarsinidenkomplex CLAs[(CO) 5 Cr] 2 ( 1 ) reagiert mit Ammoniumsalzen der Halogenid‐ und Pseudohalogenid‐Ionen Cl − , Br − , I − , CN − , N 3 und SCN − unter Bildung von anionischen 1 : 1‐Addukten. Darstellung und Eigenschaften aller Komplexe sowie die an der Verbindung HPy + (CL 2 As[(CO) 5 Cr] 2 ) − durch Röntgenstrukturanalyse belegte Konstitution werden beschrieben.
Subsequent, Unplanned Spine Surgery and Life Survival of Patients Operated for Neuropathic Spine Deformity (2011)

Survival from subsequent spine operation was similar to adolescent idiopathic scoliosis series studied in the same manner. Life survival decline began at 4 years postoperative and was significantly associated with the occurrence of one or more perioperative complications. Even after successful spine deformity surgery, this population's health status is often precarious.
Tracker Integrity Performance Assessment (2020)

In Air Traffic Management, tracking components are key to optimize traffic, by ensuring spatial separation between airplanes. The aim of the work is to propose the monitoring of the tracking system through a tracker integrity performance assessment. It is based on two components. The first one computes in quasi-real time tracking Key Performance Indicators. The second one aggregates the mandatory and recommended requirements from the Eurocontrol ESASSP standard, and the preferences of the Air Controllers on the priority among these requirements, to construct a single score representing the overall tracking quality of service. We show that these two types of requirements must be handled separately.
Effect of raw material composition on the working performance of waterborne epoxy resin for road (2020)

The purpose of the study is to clarify the curing effect of raw material composition on waterborne epoxy resin, thereby further improving working performance of waterborne epoxy resin. Based on the preferred variety of epoxy resins and curing agents, different types of waterborne epoxy resins were prepared. The effects of different raw material compositions on the physical properties of waterborne epoxy resin were studied systematically. The reasonable material composition and proportion were determined. The influence of physical properties of waterborne epoxy resin on its adhesion properties was evaluated. The results show that raw material composition has a large impact on the working performance of waterborne epoxy resin. The combination of E–44 waterborne epoxy resin and alicyclic amine has the best comprehensive property. And it is 3.65–36.22% higher than other combinations. The adhesive property index of waterborne epoxy resin has a high correlation with the mechanical property index, and they are in direct proportion.
Research progress in of soy-based wood adhesives (2011)

Soy-based wood adhesives have drawn much attention because of its outstanding performance compared to other adhesives.In this article,the mechanism,history and research progress of soy-based wood adhesives were reviewed.The new kind of cross-linking agents were especially highlighted and discussed.The problems of soy-based wood adhesives were also pointed out.
Comparison between manometric and volumetric techniques for BMP measurements (2015)

International audience
Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and β-adrenergic hyporesponsiveness in heart failure (2006)

Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC) coupling and cardiac remodeling in heart failure (HF). beta-Adrenergic hyporesponsiveness and abnormalities in Ca(2+) cycling proteins are mechanistically linked features of the HF phenotype. Accordingly, we hypothesized that XO influences beta-adrenergic responsiveness and expression of genes whose products participate in deranged EC coupling. We measured inotropic (dP/dt(max)), lusitropic (tau), and vascular (elastance; E(a)) responses to beta-adrenergic (beta-AR) stimulation with dobutamine in conscious dogs administered allopurinol (100 mg po daily) or placebo during a 4-wk induction of pacing HF. With HF induction, the decreases in both baseline and dobutamine-stimulated inotropic responses were offset by allopurinol. Additionally, allopurinol converted a vasoconstrictor effect to dobutamine to a vasodilator response and enhanced both lusitropic and preload reducing effects. To assess molecular correlates for this phenotype, we measured myocardial sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA), phospholamban (PLB), phosphorylated PLB (P-PLB), and Na(+)/Ca(2+) transporter (NCX) gene expression and protein. Although SERCA mRNA and protein concentrations did not change with HF, both PLB and NCX were upregulated (P < 0.05). Additionally, P-PLB and protein kinase A activity were greatly reduced. Allopurinol ameliorated all of these molecular alterations and preserved the PLB-to-SERCA ratio. Preventing maladaptive alterations of Ca(2+) cycling proteins represents a novel mechanism for XO inhibition-mediated preservation of cardiac function in HF, raising the possibility that anti-oxidant therapies for HF may ameliorate transcriptional changes associated with adverse cardiac remodeling and beta-adrenergic hyporesponsiveness.
Anthocyanidins and Flavonols, Major nod Gene Inducers from Seeds of a Black-Seeded Common Bean (Phaseolus vulgaris L.) (1991)

Eleven compounds released from germinating seeds of a black-seeded bean (Phaseolus vulgaris L., cv PI165426CS) induce transcription of nod genes in Rhizobium leguminosarum biovar phaseoli. Aglycones from 10 of those compounds were identified by spectroscopic methods (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy), and their biological activities were demonstrated by induction of beta-galactosidase activity in R. leguminosarum strains containing nodA-lacZ or nodC-lacZ fusions controlled by R. leguminosarum biovar phaseoli nodD genes. By making comparisons with authentic standards, the chemical structures for aglycones from the 10 molecules were confirmed as being anthocyanidins (delphinidin, petunidin, and malvidin) and flavonols (myricetin, quercetin, and kaempferol). All anthocyanidins and flavonols had 3-O-glycosylation and free hydroxyl groups at the 4', 5, and 7 positions. Hydrolysis experiments showed that the mean concentration required for half-maximum nod gene induction (I(50)) by the 10 glycosides was about half that of the corresponding aglycones. The mean I(50) value for the three anthocyanidins (360 nanomolar) was less (P </= 0.05) than that of the three flavonol aglycones (980 nanomolar). Each seed released approximately 2500 nanomoles of anthocyanidin and 450 nanomoles of flavonol nod gene inducers in conjugated forms during the first 6 hours of imbibition. Based on amounts and activities of the compounds released, anthocyanins contributed approximately 10-fold more total nod-inducing activity than flavonol glycosides. These anthocyanidins from bean seeds represent the first nod-inducing compounds identified from that group of flavonoids.
Incompetence of the Pulmonary Artery (1894)

PULMONARY ARTERY.
Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup (2017)

The Cancer Genome Atlas recently identified a genomic-based molecular classification of endometrial carcinomas, with 4 molecular categories: (1) ultramutated (polymerase epsilon [POLE] mutated), (2) hypermutated (microsatellite instability), (3) copy number abnormalities-low, and (4) copy number abnormalities-high. Two studies have since proposed models to classify endometrial carcinomas into 4 molecular subgroups, modeled after The Cancer Genome Atlas, using simplified and more clinically applicable surrogate methodologies. In our study, 151 endometrial carcinomas were molecularly categorized using sequencing for the exonuclease domain mutations (EDM) of POLE, and immunohistochemistry for p53 and mismatch repair (MMR) proteins. This separated cases into 1 of 4 groups: (1) POLE EDM, (2) MMR-D, (3) p53 wildtype (p53 wt), or (4) p53 abnormal (p53 abn). Seven gynecologic pathologists were asked to assign each case to one of the following categories: grade 1 to 2 endometrioid carcinoma (EC), grade 3 EC, mucinous, serous carcinoma (SC), clear cell, dedifferentiated, carcinosarcoma, mixed, and other. Consensus diagnosis among all 7 pathologists was highest in the p53 wt group (37/41, 90%), lowest in the p53 abn group (14/36, 39%), and intermediate in the POLE EDM (22/34, 65%) and MMR-D groups (23/40, 58%). Although the majority of p53 wt endometrial carcinomas are grade 1 to 2 EC (sensitivity: 90%), fewer than half of grade 1 to 2 EC fell into the p53 wt category (positive predictive value: 42%). Pure SC almost always resided in the p53 abn group (positive predictive value: 96%), but it was insensitive as a marker of p53 abn (sensitivity 64%) and the reproducibility of diagnosing SC was suboptimal. The limitations in the precise histologic classification of endometrial carcinomas highlights the importance of an ancillary molecular-based classification scheme.
Physiology of IgD. II. Lack of humoral immune responsiveness in lymph nodes of mice treated with anti‐IgD from birth (1982)

Previous studies have shown that anti-IgD-suppressed mice give normal primary and secondary splenic plaque-forming cell responses following i.v. challenge, although mice suppressed by the injection of anti-IgD from birth lack IgD-bearing cells in all lymphoid tissue examined. The present studies show that, in contrast, secondary immune responses in regional lymph nodes of such mice, even after i.v. priming with trinitrophenylated B. abortus, respond to a challenge injection in the footpad up to only less than 10% of control levels. When compared with respect to B cell numbers transferred, primed spleen cells from control and anti-IgD-suppressed mice are about equally effective in producing adoptive secondary plaque-forming cell responses in the spleens of recipient mice. Lymph nodes in recipients of anti-IgD-suppressed primed spleen cells show much lower responses than do lymph nodes in recipients of control primed cells, both upon immediate and delayed challenge with antigen in the footpads. It is concluded that the immunodeficiency caused by suppression with anti-IgD is much more marked in peripheral lymph nodes than in the spleen. The possible relationship of these results to the migratory properties of IgD+ as compared to IgD-B cells is discussed.
Cardiovascular actions of dogfish urotensin II in the dogfish Scyliorhinus canicula (1993)

Bolus injections of synthetic dogfish urotensin II (0.1-1.0 nmol) into the celiac artery of the conscious dogfish Scyliorhinus canicula (n = 8) resulted in sustained and dose-dependent increases in arterial blood pressure and pulse pressure. A maximum rise in mean arterial pressure of 10.5 +/- 1.2 mmHg (equivalent to 38.6 +/- 4.2% over mean basal values) and a maximum increase in pulse pressure of 3.9 +/- 0.8 mmHg was elicited by injection of 0.5 nmol of peptide. In comparison, a bolus injection of epinephrine (5 nmol) elicited a rise of 24.8 +/- 3.3% in mean arterial pressure. Bolus injection of 0.5 nmol synthetic goby (Gillichthys mirabilis) urotensin II under the same conditions did not elicit a significant hypertensive response. When dogfish urotensin II (0.5 nmol) was administered 3 min after an intra-arterial injection of phentolamine, the rise in arterial blood pressure was completely abolished. Dogfish urotensin II produced a dose-dependent contraction (pD2 = 6.58 +/- 0.07; n = 8) of isolated rings of vascular muscle prepared from the first afferent branchial artery of the dogfish. A maximum contractile force of 1.3 mN was produced by 10(-5) M peptide. The urotensin II-induced contraction of the vascular rings was unaffected by pretreatment with tetrodotoxin (1 microM) or indomethacin (14 microM). It is concluded that urotensin II has potent hypertensive activity in the dogfish that is mediated, at least in part, through release of catecholamines, but the sustained nature of the pressor response suggests that the peptide may have a direct action on the heart.
Assessment of Predictive Capability of Aeromechanics Methods (2009)

A technique is described, based on simple statistics, that can be used to assess the accuracy of analytical predictions compared to measurements. It is demonstrated that the approach can be applied to a broad range of problems in the area of helicopter aeromechanics, including hover and forward flight performance, blade aerodynamic and structural loads, vibratory forces, stability, and rotorcraft icing. The method described has both strengths and weaknesses and these are shown with examples and discussed. It is also shown that there is currently a hierarchy of accuracy in aeromechanics problems, ranging from the necessarily accurate methods for performance prediction to the inaccurate and untrustworthy calculations of fixed-system vibration.