gebhart/patrepeval huggingface dataset:
The novel genus, ‘Candidatus Phosphoribacter’, previously identified as Tetrasphaera, is the dominant polyphosphate accumulating lineage in EBPR wastewater treatment plants worldwide (2022)

The bacterial genus Tetrasphaera encompasses abundant polyphosphate accumulating organisms (PAOs) that are responsible for enhanced biological phosphorus removal (EBPR) in wastewater treatment plants. Recent analyses of genomes from pure cultures revealed that 16S rRNA genes cannot resolve the lineage, and that Tetrasphaera spp. are from several different genera within the Dermatophilaceae. Here, we examine 14 recently recovered high-quality metagenome-assembled genomes from wastewater treatment plants containing full-length 16S rRNA genes identified as Tetrasphaera, 11 of which belong to the uncultured Tetrasphaera clade 3. We find that this clade represents two distinct genera, named here Ca. Phosphoribacter and Ca. Lutibacillus, and reveal that the widely used model organism Tetrasphaera elongata is less relevant for physiological predictions of this uncultured group. Ca. Phosphoribacter incorporates species diversity unresolved at the 16S rRNA gene level, with the two most abundant and often co-occurring species encoding identical V1-V3 16S rRNA gene amplicon sequence variants but different metabolic capabilities, and possibly, niches. Both Ca. P. hodrii and Ca. P. baldrii were visualised using fluorescence in situ hybridisation (FISH), and PAO capabilities were confirmed with FISH-Raman microspectroscopy and phosphate cycling experiments. Ca. Phosphoribacter represents the most abundant former Tetrasphaera lineage and PAO in EPBR systems in Denmark and globally.
Joint Least Squares Estimation of Frequency, DC Offset, I-Q Imbalance, and Channel in MIMO Receivers (2008)

Multiple-input-multiple-output (MIMO) receivers with direct-conversion radio-frequency (RF) architecture are investigated in this paper. Direct conversion is a low-cost RF design that requires fewer external components in chip implementation. Nevertheless, it introduces extra RF impairments such as I-Q imbalance and dc offset in addition to frequency offset that is commonly encountered in all RF architectures. This paper proposes to do the joint least squares (LS) estimation of frequency, dc offset, I-Q imbalance, and a channel in MIMO receivers to improve performance; frequency-dependent and frequency-independent I-Q imbalances are included. Previously, RF impairments were separately estimated in MIMO receivers, which leads to inferior performance. In particular, a receiver architecture that facilitates the joint estimation of the frequency, the dc offset, the I-Q imbalance, and the channel is proposed. The LS criterion is then applied to obtain the joint estimators, with a special training-sequence design to reduce complexity. Simplified estimators on the frequency and dc offset are also proposed with almost no loss in performance. Finally, the estimators are shown through analysis to be unbiased and approach the Cramer-Rao lower bound (CRLB) for signal-to-noise ratios (SNRs) of interest. The analysis is verified by computer simulations.
Spectroscopic Study of Terahertz Generation in Mid-Infrared Quantum Cascade Lasers (2016)

Terahertz quantum cascade laser sources based on intra-cavity difference-frequency generation are currently the only room-temperature mass-producible diode-laser-like emitters of coherent 1-6 THz radiation. Device performance has improved dramatically over the past few years to reach milliwatt-level power output and broad tuning from 1.2 to 5.9 THz, all at room-temperature. Terahertz output in these sources originates from intersubband optical nonlinearity in the laser active region. Here we report the first comprehensive spectroscopic study of the optical nonlinearity and investigate its dependence on the mid-infrared pump frequencies. Our work shows that the terahertz generation efficiency can vary by a factor of 2 or greater depending on the spectral position of the mid-infrared pumps for a fixed THz difference-frequency. We have also measured for the first time the linewidth for transitions between the lower quantum cascade laser states, which is critical for determining terahertz nonlinearity and predicting optical loss in quantum cascade laser waveguides.
Multichannel urodynamics: ambulatory versus standard urodynamics (1999)

Standard urodynamics in the office setting has been the mainstay of urodynamic evaluation. Ambulatory urodynamics has previously been viewed as a research tool only. This article summarizes new studies on ambulatory urodynamics that highlight its potentially more practical and clinical use.
Micellar catalysis of ester hydrolysis. Influence of chirality and head group structure in simple surfactants (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicellar catalysis of ester hydrolysis. Influence of chirality and head group structure in simple surfactantsRobert A. Moss and Warren L. SunshineCite this: J. Org. Chem. 1974, 39, 8, 1083–1089Publication Date (Print):April 1, 1974Publication History Published online1 May 2002Published inissue 1 April 1974https://pubs.acs.org/doi/10.1021/jo00922a015https://doi.org/10.1021/jo00922a015research-articleACS PublicationsRequest reuse permissionsArticle Views526Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sustainable bio-based furan epoxy resin with flame retardancy (2019)

A sugar-based bis-furan diepoxide (OmbFdE) was developed which imparted epoxy resins with excellent fire retardancy.
LITE SABR M1: a Phase I Trial of Lattice Stereotactic Body Radiotherapy for Large Tumors (2021)

Abstract Purpose Stereotactic body radiotherapy (SBRT) is an attractive treatment option for patients with metastatic and/or unresectable tumors, however its use is limited to smaller tumors. Lattice is a form of spatially fractionated radiotherapy that may offer safe delivery of SBRT for bulky tumors. We previously described Lattice SBRT, which delivers 20 Gy in 5 fractions with a simultaneous Lattice boost to 66.7 Gy. The goal of this study was to prospectively evaluate the acute toxicity and quality of life (QoL) of patients with large tumors (&gt; 5 cm) treated with Lattice SBRT. Methods This was a single-arm phase I trial conducted between October 2019 and August 2020. Patients with tumors &gt;4.5 cm were eligible. Lattice SBRT was delivered every other day.. The primary outcome was the rate of 90-day treatment-associated (probably or definitely attributable) grade 3+ acute toxicity by Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 criteria. Other outcomes included changes in patient reported toxicity and QoL inventories, GTV, and peripheral blood cytokines. Results Twenty patients (22 tumors) were enrolled. Median GTV was 783 cc (range: 64-3713 cc). Fifty percent of tumors were in the thorax, 45% abdomen/pelvis, and 5% extremity. There was no treatment-associated grade 3+ toxicity.. There was one case of grade 4 toxicity possibly associated with Lattice SBRT. Conclusions This phase I study met its primary endpoint of physician reported safety. An ongoing phase II clinical trial of Lattice SBRT will evaluate late safety and efficacy of this novel technique.
Macroscopic Directional Analysis of Pedestrian Flow (2016)

Incidents at mass gatherings all over the world continue to raise concern about pedestrian safety. This rising concern calls for researchers to understand the underlying dynamics behind pedestrian and mass movements. The literature offers several approaches that reproduce reality to varying degrees, simulate it, and model it under different circumstances. Across these approaches, limited effort has been invested in looking at the projection of flow measures along different directions of travel (e.g., longitudinal versus lateral movement in omnidirectional environments) at the macroscopic level. To address this gap, this paper looks at directional flows and speeds and how they relate to each other at the macroscopic level. The results from analysis of experimental three-dimensional trajectory data show that a macroscopic analysis of directional travel, particularly of lateral travel, helps explain when and to what extent sidestepping occurs in the corridor. An increase in areawide density results in a decrease in flow in the direction of travel but increases the lateral direction flow. Furthermore, the relationship between speed and density in the lateral direction delineates two regimes in the corridor, whereby pedestrians do not increase their speed in the lateral direction until areawide density levels reach magnitudes that cause an areawide capacity drop in the system. The work in this paper therefore suggests that there is useful insight to be gained by complementing nondirectional flow analysis with directional flow analysis.
HDLand endothelial protection (2013)

High-density lipoproteins (HDLs) represent a family of particles characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver. In addition to this function, HDLs display pleiotropic effects including antioxidant, anti-apoptotic, anti-inflammatory, anti-thrombotic or anti-proteolytic properties that account for their protective action on endothelial cells. Vasodilatation via production of nitric oxide is also a hallmark of HDL action on endothelial cells. Endothelial cells express receptors for apoA-I and HDLs that mediate intracellular signalling and potentially participate in the internalization of these particles. In this review, we will detail the different effects of HDLs on the endothelium in normal and pathological conditions with a particular focus on the potential use of HDL therapy to restore endothelial function and integrity.
Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients (2016)

Spleen tyrosine kinase (SYK) is a protein kinase involved in cell proliferation and the regulation of inflammatory pathways. Due to the increasing evidence that kinase inhibitors have potential as specific anti-inflammatory drugs, we have investigated the potential for SYK inhibition as a therapeutic target in autoimmune diseases, particularly cutaneous lupus erythematosus (CLE). Skin samples of patients with different CLE subtypes and appropriate controls were analysed for the expression of SYK and SYK-associated pro-inflammatory mediators via gene expression analysis and immunohistochemistry. The functional role of SYK in keratinocytes was investigated in vitro, using LE-typical pro-inflammatory stimuli and a selective inhibitor of SYK. SYK-associated genes are strongly upregulated in CLE skin lesions. Importantly, phosphorylated SYK (pSYK) is strongly expressed by several immune cell types and also keratinocytes in CLE skin. In vitro, immunostimulatory nucleic acids are capable of inducing SYK phosphorylation in keratinocytes leading to the induction of pro-inflammatory cytokines, while small-molecule SYK inhibition decreases the expression of these proteins. The results demonstrate that pSYK is expressed by immune cells and keratinocytes in skin lesions of CLE patients. LE-typical stimuli induce the expression of pSYK in vitro. Small-molecule SYK inhibition leads to a reduction of pSYK expression and downregulation of pro-inflammatory cytokines in keratinocytes. We therefore believe that pSYK provides a potential future drug target for the treatment of patients who suffer from CLE and related skin disorders. Specifically, our study reveals evidence supporting the use of topical SYK inhibitors in treating lupus.
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy (2021)

Dysregulation of lipid metabolism affects the behavior of cancer cells, but how this happens is not completely understood. Neutral sphingomyelinase 2 (nSMase2), encoded by <i>SMPD3</i>, catalyzes the breakdown of sphingomyelin to produce the anti-oncometabolite ceramide. We found that this enzyme was often downregulated in human metastatic melanoma, likely contributing to immune escape. Overexpression of nSMase2 in mouse melanoma reduced tumor growth in syngeneic wild-type but not CD8-deficient mice. In wild-type mice, nSMase2-overexpressing tumors showed accumulation of both ceramide and CD8<sup>+</sup> tumor-infiltrating lymphocytes, and this was associated with increased level of transcripts encoding IFNγ and CXCL9. Overexpressing the catalytically inactive nSMase2 failed to alter tumor growth, indicating that the deleterious effect nSMase2 has on melanoma growth depends on its enzymatic activity. <i>In vitro</i>, small extracellular vesicles from melanoma cells overexpressing wild-type nSMase2 augmented the expression of IL12, CXCL9, and CCL19 by bone marrow-derived dendritic cells, suggesting that melanoma nSMase2 triggers T helper 1 (Th1) polarization in the earliest stages of the immune response. Most importantly, overexpression of wild-type nSMase2 increased anti-PD-1 efficacy in murine models of melanoma and breast cancer, and this was associated with an enhanced Th1 response. Therefore, increasing <i>SMPD3</i> expression in melanoma may serve as an original therapeutic strategy to potentiate Th1 polarization and CD8<sup>+</sup> T-cell-dependent immune responses and overcome resistance to anti-PD-1.
Bytecode-based Java program analysis (1999)

Program analysis is the process of collecting control and data-flow information from a program. Current automated program analysis tools employ front-ends that process a program at the source code level. Unfortunately, creating such a conventional front-end is an expensive undertaking -akin to writing the front-end of a compiler. This article presents a new approach to building front-ends for automated program analysis tools. In this approach, a front-end processes a Java program at the object code level.
Opiate Detection in Saliva and Urine—A Prospective Comparison by Gas Chromatography–Mass Spectrometry (1999)

Saliva, of adequate amount in 85% of samples, may be appropriate for analysis of drugs of abuse.
Mohr's Salt Hexahydrate: A Novel, Cheap and Powerful Reagent for Green Synthesis of Biscoumarins on Water (2013)

Abstract A new and convenient method for the synthesis of biscoumarins based on the condensation of 4‐hydroxycoumarin and aromatic aldehydes in the presence of Mohr's salt hexahydrate (ferrous ammonium sulfate hexahydrate) as a novel catalyst on water is developed. This method has advantages such as the use of inexpensive and available reagent, avoidance of organic solvents, short reaction times, and high product yields.
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells (2014)

G(i)α proteins differentially regulate the activation of Akt, mTORC1 and ERK1/2 by different families of growth factors. G(i)α proteins are important for breast cancer cell growth and invasion.
Synthesis and Properties of YBa2Cu4O8 Superconductor by Aerosol Flow Reacting Method (1990)

The superconducting phase YBa 2 Cu 4 O 8 has been synthesized using an aerosol flow reacting method with starting solutions containing stoichiometric compositions of Y/Ba/Cu=1/2/4. The powders obtained were spherical and their diameters were uniformly distributed below 1 µm. The heat treatment was made at about 800°C for 5 h in flowing oxygen. The sintered bodies fabricated from these powders show the onset of superconducting transition at 80 K. Our result shows that the YBa 2 Cu 4 O 8 phase can be synthesized in a short time in the form of the fine powder using an aerosol flow reacting method.
Estimating the Energy Consumption in Pervasive Java-Based Systems (2008)

We define and evaluate a framework for estimating the energy consumption of pervasive Java-based software systems. The framework's primary objective is to enable an engineer to make informed decisions when adapting a system's architecture, such that the energy consumption on hardware devices with a finite battery life is reduced, and the lifetime of the system's key software services increases. Our framework explicitly takes a component-based perspective, which renders it well suited for a large class of today's distributed, embedded, and pervasive applications. The framework provides a novel approach that facilitates the accurate estimation of a system's energy consumption both during system construction-time and during runtime. In a large number of distributed application scenarios, the framework showed very good precision on the whole, giving results that were within 5% of the actually measured power losses incurred by executing the software.
Etude de la propagation et de la bifurcation de fissures de fatigue en plasticité généralisée (2017)

National audience
NOx Storage and Reduction on Pt/Alumina Catalysts:  Effects of Alkaline-Earth and Rare-Earth Metal Additives (2005)

A series of Pt/Al2O3 catalysts, modified with alkaline-earth or rare-earth metal oxides, were prepared by the incipient-wetness impregnation method. The catalysts were characterized by N2 sorption, scanning electron microscopy, and transmission electron microscopy. The performance and durability of NOx storage of the catalysts were investigated under a lean-burn/rich-burn cycle process. The effects of reaction temperature on the capacity for NOx and duration of the catalysts were also studied. The transient experiments consisted of a storing phase using a lean gas mixture (NO/O2/N2/C3H6/CO) and a regeneration phase during which the O2 flow was switched off. The catalysts consisted of nonuniform aggregates of very small and distinct particles. The barium-promoted catalyst had better storage capability and duration. On the other hand, the cerium-promoted catalyst had a higher NO storage capability than those without cerium. Comparing the influences of cerium and lanthanum additives, Pt2.5Ce30.5Ba33.4Al100 had a storage capacity of 1020 × 10-6 mol/g at 30 min, but Pt2.5La30.5Ba33.4Al100 had a storage capacity of 341 × 10-6 mol/g. The catalysts containing both barium and cerium demonstrated high NO storage/conversion. The best compositions of the catalysts for high NO storage capacity were Pt2.5Ce30.5Ba33.4Al100 (1020 μmol/g) and Pt2.5Ce22.5Ba41.7Al100 (911 μmol/g). The operating temperature also had a pronounced effect on both NO storage and reduction. The best operating range was 350−400 °C.
Poly ICLC Induces Anti-IC Antibodies in Mice and Rabbits (1984)

Poly ICLC is an interferon (IFN) inducer and antiviral, antitumor, radioprotective, and immunoregulatory agent. We show that administration of poly ICLC to mice and rabbits also results in the presence of anti-IC antibodies in their serum.
Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection (2022)

[This corrects the article DOI: 10.1371/journal.ppat.1010219.].
Facile Synthesis of Gold Nanoparticles for Anticancer, Antioxidant Applications, and Photocatalytic Degradation of Toxic Organic Pollutants (2022)

In the current study, a facile, rapid, and ecologically safe photosynthesis of gold nanoparticles (AuNPs) that remained stable for 3 months is reported to advocate the main aspects of green chemistry, such as safer solvents and auxiliaries, and the use of renewable feedstock. <i>Zi</i>-AuNPs were phytosynthesized by the aqueous extract of <i>Ziziphus spina-christi</i> leaves, and numerous techniques were employed for their characterization. The results demonstrated the successful phytofabrication of crystalline AuNPs with brownish-black color, spherical nanoparticles with a size between 0 and 10 nm, a plasmon peak at 540 nm, and a surface charge of -25.7 mV. <i>Zi</i>-AuNPs showed an effective photodegradation efficiency (81.14%) against malachite green and a good recycling capacity of 69.2% after five cycles of regeneration. The cytotoxicity test by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay signified a high anticancer efficiency for both <i>Zi</i>-AuNPs and <i>Z. spina-christi</i> extract against human breast cancer cells (MCF7 cell line) with IC<sub>50</sub>'s of 48 and 40.25 μg/mL, respectively. Highly efficient antioxidant capabilities were proven with 2,2-diphenyl-1-picrylhydrazyl (DPPH) removal percentages of 67.5% for <i>Zi</i>-AuNPs and 92.34% for <i>Z. spina-christi</i> extract.
Development of a 1D-2D coupled hydrodynamic model for the Øyeren Delta in southern Norway (2011)

In this study a coupled 1D-2D hydrodynamic model, MIKE FLOOD was used to simulate flood inundation extent, water levels and water velocities in the delta region of Lake Øyeren in southern Norway. The objective was to evaluate the improvement gained using a more complex framework. In addition, the credibility of existing flood zone maps made for Lillestrøm by Norges Vassdrag- og Energidirektorat (NVE) in 2005 was assessed. They were based on the assumption that the water levels predicted for Fetsund were applicable for the construction of \nflood zone maps at Lillestrøm. The model was set up and calibrated from historical hydrometric data as well as newly measured data. A methodology to correctly integrate the data required for flood inundation modeling was put forward. In addition, an assessment of the model sensitivity to various factors such as interpolation method, mesh resolution and model parameters was performed. The model performance seems to be greatly influenced by the quality of the digital elevation model (DEM), and hence also influenced by methods used to interpolate bathymetry, and mesh resolution. According to the results from the model, the assumption behind flood zone maps was determined to be conservative, overestimating water levels at Lillestrøm. The simulations also show a model capable of representing the hydraulic conditions of the delta, and demonstrate that the use of advanced numerical methods is now feasible, being an efficient way \nto obtain flood information. \n\nKeywords MIKE FLOOD.Delta.Flood Management.Numerical methods.Model responses
Techniques in Treating Mild or High-level Aphasic Impairment (1980)

TBA
Solar Thermal Plant Integration into an Industrial Process (2014)

The present abstract summarizes the main analysis and design steps made for the integration of a solar thermal plant of one thousand square meters into the dyeing process of Benetton industrial facility in Tunisia. The analysis of the actual process load is done by a static model based on assumed energy and water consumptions and the real performance of the heat recovery system. The methodology to build the simplified model and its validation by monitored data will be presented. The results show the optimization potential of the heat recovery system and the temperature constraints for a good integration of the solar plant. This study presents some choices to reach an optimized integration of the solar plant and the sizing of the main components. The main design alternatives are evaluated in this article based on dynamic simulations and personal experience.