gebhart/patrepeval huggingface dataset:
Thyronin Treatment in Adult and Pediatric Heart Surgery: Clinical Experience and Review of the Literature (2002)

Thyroid hormone has multiple direct and indirect effects on the heart and the vasculature. Many signs and symptoms of thyroid dysfunction are manifest by the cardiovascular system. Furthermore, many cardiovascular diseases are adversely affected by the concomitant presence of either hyper- or hypothyroidism: it is still being debated whether these alterations are the consequence of increased cardiac workload alone or are due to the intrinsic properties of thyroid hormone. There are three potential mechanisms by which thyroid hormone might exert a cardiovascular action: (1) direct effects at the cellular level (inotropic and chronotropic effect); (2) interaction with the sympathetic nervous system; and (3) alteration of the peripheral circulation through changes in preload, afterload and energy metabolism. We treated 54 adult and seven pediatric patients suffering from severe low cardiac output in different clinical conditions with a mean bolus dosage of 2+/-1.5 microg h(-1) of T(3), followed by a continuous infusion of 0.4+/-0.3 microg h(-1) for a mean duration of 48+/-12 h. In 45 patients, stabilization of the hemodynamic situation with a decrease in inotropic support requirement was observed; however, in 11 patients no beneficial effects were observed. From this experience we suggest that T(3) treatment may improve hemodynamics in a substantial proportion of cardiac and cardiosurgical patients in whom more conventional treatment is unsuccessful.
Nicotinic Acid Inhibits Glucose-Stimulated Insulin Secretion Via the G Protein-Coupled Receptor PUMA-G in Murine Islet β Cells (2011)

The results indicated that PUMA-G stimulation by NA in islet β cells inhibited GSIS likely via activation of the Gi signaling pathway.
Reversible Posterior Leukoencephalopathy Occurring during Resection of a Posterior Fossa Tumor: Case Report and Review of the Literature (2001)

RPL can occur as a result of intraoperative variations in blood pressure, even among young, previously healthy individuals. With the aforementioned interventions, the patient experienced significant clinical and radiographic recovery.
DrugBank and its Relevance to Pharmacogenomics (2008)

DrugBank is a freely available web-enabled database that combines detailed drug data with comprehensive drug-target and drug-action information. It was specifically designed to facilitate in silico drug-target discovery, drug design, drug-metabolism prediction, drug-interaction prediction, and general pharmaceutical education. One of the most unique and useful components of the DrugBank database is the information it contains on drug metabolism, drug-metabolizing enzymes and drug-target polymorphisms. As pharmacogenomics is fundamentally concerned with the role of genes and genetic variation of how an individual responds to a drug, DrugBank is able to offer a convenient venue to explore pharmacogenomic questions in silico. This paper provides a brief overview on DrugBank and how it can facilitate pharmacogenomic research.
Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation (2014)

We thank Dr Tsuda 1 for the important remark and his interest in our work. Unfortunately, we did not perform measurements on the effect of diltiazem on sympathetic nerve activity in our study and as mechanism of action of the drug we observed some direct inhibitory action on the inflammatory activity of cultured monocytic cells. 2 Nevertheless, we agree that our proposed mechanism is probably not the only one operative in the highly complex model of angiotensin II-induced aneurysm formation in ApoE -/-mice 3 and that diltiazem in vivo may have additional effects. A role of the sympathetic nervous system in vascular inflammatory processes is established, 4 and in high concentrations diltiazem is known to inhibit neuronal voltagedependent calcium channels. 5 Thus, the mechanism proposed by Dr Tsuda is indeed plausible to contribute to the antianeurysmal effect of Diltiazem.
Fluctuations in millimeter-wave signals propagated through inclement weather (1988)

Results are presented from measurements of the effects of inclement weather on the fluctuations in amplitude and phase of millimeter-wave (MMW) signals propagated through the atmosphere. These measurements were made at frequencies near 116, 140, 173, and 230 GHz at a site near Champaign-Urbana, Illinois, in a community chosen for its exceptional flatness and lack of terrain features that might perturb the atmosphere. It was found that this inclement weather fluctuations are generally smaller than those observed in clear air under sunny conditions, and are also smaller than the corresponding effects observed at visible and near-infrared wavelengths. Rain has the greatest effect on MMW transmission, causing large, slow changes in received signal strength as a function of rain rate. It should also be noted that rain caused the only observed loss of the propagation link, during a thunderstorm in which the rain rate was as high as 60 mm/h. It is concluded that, in general, millimeter-wave radiation propagates well in adverse weather, with rain causing the major problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A novel design for the construction and startup of an eight inch pilot line (2003)

An 8-in wafer line with 0.5- mu m CMOS process technology for DRAM and SRAM pilot production is discussed. The pilot line is expected to achieve: (1) speedy construction and startup with overall duration of 16 months; (2) a class-0.1 clean environment at 0.3- mu m particle testing level; (3) the flexibility to advance to 0.2- mu m process technology when needed; (4) the flexibility to enlarge the processing capacity to mass production level (if needed) without interrupting pilot line production. Principles of this design are outlined, difficulties encountered on implementation are discussed, solution approaches employed are illustrated, and preliminary startup results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3GPP SA2 architecture and functions for 5G mobile communication system (2017)

The on-going development of Fifth Generation (5G) mobile communication technology will be the cornerstone for applying Information and Communication Technology (ICT) to various fields, e.g., smart city, smart home, connected car, etc. The 3rd Generation Partnership Project (3GPP), which has developed the most successful standard technologies in the mobile communication market such as Universal Mobile Telecommunication System (UMTS) and Long Term Evolution (LTE), is currently carrying out the standardization of both 5G access network system and 5G core network system at the same time. Within 3GPP, Service and System Aspects Working Group 2 (SA2) is responsible for identifying the main functions and entities of the network. In December 2016, the 3GPP SA2 group finalized the first phase of study for the architecture and main functions of 5G mobile communication system under the study item of Next Generation system (NextGen). Currently, normative standardization is on-going based on the agreements made in the NextGen Phase 1 study. In this paper, we present the architecture and functions of 5G mobile communication system agreed in the NextGen study.
Chemotaxis under flow disorder shapes microbial dispersion in porous media&#160; (2021)

&amp;lt;div&amp;gt; &amp;lt;div&amp;gt; &amp;lt;div&amp;gt; &amp;lt;p&amp;gt;Natural soils are host to a high density and diversity of microorganisms, and even deep-earth porous rocks provide a habitat for active microbial communities. In these environ- ments, microbial transport by disordered flows is relevant for a broad range of natural and engineered processes, from biochemical cycling to remineralization and bioremediation. Yet, how bacteria are transported and distributed in the sub- surface as a result of the disordered flow and the associ- ated chemical gradients characteristic of porous media has remained poorly understood, in part because studies have so far focused on steady, macroscale chemical gradients. Here, we use a microfluidic model system that captures flow disorder and chemical gradients at the pore scale to quantify the transport and dispersion of the soil-dwelling bacterium Bacillus subtilis in porous media. We observe that chemotaxis strongly modulates the persistence of bacteria in low-flow regions of the pore space, resulting in a 100% increase in their dispersion coefficient. This effect stems directly from the strong pore-scale gradients created by flow disorder and demonstrates that the microscale interplay between bacterial behaviour and pore-scale disorder can impact the macroscale dynamics of biota in the subsurface.&amp;lt;/p&amp;gt; &amp;lt;/div&amp;gt; &amp;lt;/div&amp;gt; &amp;lt;/div&amp;gt;
Influence of nanoparticles on the haemostatic balance: between thrombosis and haemorrhage (2021)

Maintenance of a delicate haemostatic balance or a balance between clotting and bleeding is critical to human health. Irrespective of administration route, nanoparticles can reach the bloodstream and might interrupt the haemostatic balance by interfering with one or more components of the coagulation, anticoagulation, and fibrinolytic systems, which potentially lead to thrombosis or haemorrhage. However, inadequate understanding of their effects on the haemostatic balance, along with the fact that most studies mainly focus on the functionality of nanoparticles while forgetting or leaving behind their risk to the body's haemostatic balance, is a major concern. Hence, our review aims to provide a comprehensive depiction of nanoparticle-haemostatic balance interactions, which has not yet been covered. The synergistic roles of cells and plasma factors participating in haemostatic balance are presented. Possible interactions and interference of each type of nanoparticle with the haemostatic balance are comprehensively discussed, particularly focusing on the underlying mechanisms. Interactions of nanoparticles with innate immunity potentially linked to haemostasis are mentioned. Various physicochemical characteristics that influence the nanoparticle-haemostatic balance are detailed. Challenges and future directions are also proposed. This insight would be valuable for the establishment of nanoparticles that can either avoid unintended interference with the haemostatic balance or purposely downregulate/upregulate its key components in a controlled manner.
ARGOS - Online mode processor architectural design (2008)

This Document describes the strategy for implementing the specified features for the ARGOS On-Board SAR processor online mode.&#13;\nProject managers, as well as software engineers are the intended audience.
REMARKS ON STOCHASTIC PROPERTIES OF MATERIALS THROUGH FINITE DEFORMATIONS (2015)

International audience
Olig Transcription Factors Are Expressed in Oligodendrocyte and Neuronal Cells in Human Fetal CNS (2005)

The transcription factors Olig1 and Olig2 are closely associated with the development of oligodendrocyte (OL) lineage in the vertebrate nervous system, but little is known about their role in the human developing CNS. To test the hypothesis that they contribute to initial OL specification in humans, we studied the expression of Olig1 and Olig2 in human fetuses at 5-24 gestational weeks (GW). Both transcription factors were present in well outlined regions of the ventral neuroepithelium at 5 GW, several weeks before oligodendrogenesis. Spatial differences in the expression of Olig1 and Olig2 along the neuronal axis suggest that they specify different subpopulations of progenitor cells. Olig1 was distributed rostrally, from the basal forebrain to the hindbrain, whereas Olig2 was also found in the ventral spinal cord. Furthermore, at 5 GW, Olig1 was coexpressed with vimentin, and Olig2 was coexpressed with a neuronal marker, microtubule-associated protein 2. With the progression of development at 15 GW, both proteins were present throughout the spinal cord and the ventricular-subventricular zone of the ganglionic eminences, whereas at midgestation (20 GW), they were also expressed in the telencephalic proliferative zones and the emerging white matter. Double-labeling studies revealed that early OL progenitor cells and radial glia expressed Olig1, whereas Olig2 was localized predominantly in mature OLs and a subset of neural progenitor cells and mature neurons. Thus, Olig1 and Olig2 transcription factors in the human CNS are important not only for differentiation of the OL lineage, but they may also have a role in neural cell specification.
A Simple and Efficient System for Green Note Compound Biogenesis by Use of Certain Lipoxygenase and Hydroperoxide Lyase Sources (2005)

Six-carbon (C(6)) aldehydes and alcohols are important components of the aroma and flavor of fruits and vegetables. Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products. Here, we examined the effects of LOX 3 on hexenal formation from linolenic acid homogenized with watermelon 13-hydroperoxide lyase (HL)-overexpressing Nicotiana tabacum leaves and soybean acetone powder. Compared to the wild type, which contains LOXs 1, 2, and 3, the elimination of LOX 3 in LOX 1 + 2 facilitates greater production of hexenals. The use of LOX 2 alone yielded the highest hexenal production, while a two-step conversion was required for LOX 1 to produce hexenals at high levels due to different pH optima of the enzymes involved. These results clearly demonstrate that the soybeans lacking LOX 3 in combination with watermelon HL-overexpressing leaf tissues greatly enhance hexenal formation.
Successful Clearance of 300 Day SARS-CoV-2 Infection in a Subject with B-Cell Depletion Associated Prolonged (B-DEAP) COVID by REGEN-COV Anti-Spike Monoclonal Antibody Cocktail (2021)

A 59-year-old male with follicular lymphoma treated by anti-CD20-mediated B-cell depletion and ablative chemotherapy was hospitalized with a COVID-19 infection. Although the patient did not develop specific humoral immunity, he had a mild clinical course overall. The failure of all therapeutic options allowed infection to persist nearly 300 days with active accumulation of SARS-CoV-2 virus mutations. As a rescue therapy, an infusion of REGEN-COV (10933 and 10987) anti-spike monoclonal antibodies was performed 270 days from initial diagnosis. Due to partial clearance after the first dose (2.4 g), a consolidation dose (8 g) was infused six weeks later. Complete virus clearance could then be observed over the following month, after he was vaccinated with the Pfizer-BioNTech anti-COVID-19 vaccination. The successful management of this patient required prolonged enhanced quarantine, monitoring of virus mutations, pioneering clinical decisions based upon close consultation, and the coordination of multidisciplinary experts in virology, immunology, pharmacology, input from REGN, the FDA, the IRB, the health care team, the patient, and the patient's family. Current decisions to take revolve around patient's follicular lymphoma management, and monitoring for virus clearance persistence beyond disappearance of REGEN-COV monoclonal antibodies after anti-SARS-CoV-2 vaccination. Overall, specific guidelines for similar cases should be established.
Off-line (Optimal) multiprocessor scheduling of dependent periodic tasks (2012)

This paper addresses the global scheduling of constrained deadline periodic dependent task sets on multiprocessor platforms composed of identical processors. We propose two orthogonal approaches: (1) an off-line computation of a valid fixed priority assignment (2) a computation of an off-line schedule. The method in both cases is based on the efficient exploration of a finite automaton encoding all the possible executions. Even if the problems are NP-complete, we obtain rather reasonable performances as illustrated in the benchmarks.
Color Quality of Fresh and Processed Strawberries (2008)

Color and appearance are very important quality attributes of fresh and processed strawberries (Fragaria x ananassa Duch. ex Rozier). In evaluating new germplasm, the plant breeder considers size, shape, uniformity, along with hue and whether the berries are too light or too dark. The attractive color of fresh strawberries is dramatically affected by processing. While some pigment degradation occurs with freezing, physical changes, which are manifested by drip loss, are largely responsible for deterioration of appearance. Canning and manufacture into jam, juice, and wine results in marked color degradation. Anthocyanin pigment degradation and accompanying browning reactions cause their color deterioration. Reaction of anthocyanins with enzymes, ascorbic acid, acetaldehyde and other reactive compounds account for much of the pigment degradation. L*, hue angle and chroma are very useful indices for monitoring color change, and they are complementary to measurement of total anthocyanins, polymeric color and anthocyanin pigment profiles.
The importance of diagnosing genital herpes (2001)

Genital herpes is the result of infection by herpes simplex virus type 2 (HSV-2) and, to a lesser extent, HSV-1. Recent years have seen a rise in the prevalence of genital HSV infection in both industrialized and developing countries. The main factors attributed to the spread of HSV infection include asymptomatic virus shedding, and under-recognition and under-diagnosis of the disease. At the level of the individual patient, genital herpes is associated with significant psychosocial morbidity and complications such as neonatal herpes, the result of transmission of HSV from mother to baby. HSV-2 infection is also implicated in the transmission and acquisition of human immunodeficiency virus (HIV). As genital HSV infection has substantial public health implications, increased awareness of the disease and its prevalence, together with better use of diagnostic tests, may be one step towards more effective management and infection control.
Topologies and design considerations for distributed power system applications (2001)

This paper describes developments in the technology of converters primarily intended for server-type distributed power system (DPS) applications. The paper first addresses the single-phase two-stage DPS, discussing the available options for simple power factor correction and high-performance DC-DC converters. Next, the concept is extended to three-phase high-power front-end converters, which also use a two-stage approach. Finally the paper presents the developments in load converters, with emphasis on low-, medium-, and high-voltage regulator modules used to supply high-performance microprocessors. The discussion throughout the paper is supported by an extensive list of references and experimental results.
Discrepancy in alloy composition of imported and non-imported porcelain-fused-to-metal (PFM) crowns produced by Norwegian dental laboratories (2020)

<b>Purpose:</b> Even though the use of full ceramic crowns have become a well-established practice in dental clinics compare to the last decade, the use of imported casted porcelain-fused-to-metal (PFMs) crowns is still prevalent. The use of imported PFMs is often economically driven; however, when dentists order PFMs, they do not have capabilities to examine its true alloy content. Therefore, we raise the questions whether cheaper imported PFMs have more discrepancies in alloy content compared to domestically produced PFMs? <b>Materials and Methods:</b> This study included 62 porcelain-fused-to-metal crowns: 41 produced in Norway and 21 imported. Their alloy-composition was determined non-destructively by EDX and SEM. <b>Results and Conclusions:</b> Imported PFMs demonstrated larger deviations compared with non-imported PFMs. Significant deviation was found in key metallic elements in the different alloys (W, In, Pd, Ag). The detected deviations in key element such as Wolfram and Indium could influence the PFMs service time. These finding may be of international concern.
Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region (2002)

Somatic hypermutation (SHM) and class switch recombination (CSR) cause distinct genetic alterations at different regions of immunoglobulin genes in B lymphocytes: point mutations in variable regions and large deletions in S regions, respectively. Yet both depend on activation-induced deaminase (AID), the function of which in the two reactions has been an enigma. Here we report that B cell stimulation which induces CSR but not SHM, leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region, uncoupled with CSR. These findings strongly suggest that AID itself or a single molecule generated by RNA editing function of AID may mediate a common step of SHM and CSR, which is likely to be involved in DNA cleavage.
Elaboration d'un kit diagnostique pour test de provocation nasale au persulfate (2001)

Afin de diagnostiquer une allergie professionnelle au persulfate (agent present dans les teintures) chez le personnel des salons de coiffure, un test de provocation nasale a ete mis au point en collaboration avec les medecins. Pour realiser ce test, il est necessaire de disposer d'une solution stable de persulfates. L'etude de stabilite d'une solution de 1 % de persulfates a montre que celle-ci etait stable 9 h a 25 °C. En pratique, la pharmacie prepare un kit comprenant des flacons de tampon et de persulfate a diluer extemporanement. La solution diluee est stable tout au long de la realisation clinique du test.
Une zone funéraire gallo-romaine aux Rues-des-Vignes (Nord) (1999)

Denis Gaillard en Daniel Roger, Een galloromeins grafveld in Rues-des- Vignes (Nord). Het dorp Rues-des-Vignes (Nord) heeft een galloro- meinse bewoning gekend, waarvan men de geografie en chronologie niet kent. De ontdekking van een tweede grafveld, naast dat van het sportcentrum (1976), is een nieuw geografisch element voor de galloromeinse bewoning. Men heeft zes verassingsgraven blootgelegd en drie andere. De overblijfselen bevinden zich in de origi- nele stratigrafie, waarin graf- en bezettingslagen afwis- selen. De site werd waarschijnlijk bezet tussen het einde van de eerste en het einde van de derde eeuw.
Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression. (2005)

Serotonin 5-HT2A receptor antagonists have been shown to attenuate the locomotor stimulant effects of cocaine in rats. The present study used the expression of c-Fos protein as a marker to identify brain areas through which 5-HT2A receptors may modulate cocaine-induced behaviors. Significant correlations were observed between cocaine-induced hyperactivity and c-Fos expression in the nucleus accumbens core (NAcC), caudate-putamen (CPu), and subthalamic nucleus. In a separate experiment, a low, behaviorally relevant dose of cocaine was found to increase c-Fos immunoreactivity in the medial CPu, NAcC, and nucleus accumbens shell (NAcSh). The selective 5-HT2A receptor antagonist M100907 significantly attenuated cocaine-induced c-Fos expression in the medial CPu and in the NAcSh. These data suggest that 5-HT2A receptors in the NAcSh and CPu or in afferents to these regions may contribute to genomic responses to cocaine in the brain as well as to cocaine-induced locomotor activity.
Negative Thermal Expansion in Open Perovskites near the Precipice of Structural Stability (2018)

Invited paper for Frontiers Chemistry (Research Topic: Towards the Control of Thermal Expansion: from 1996 to today)