gebhart/patrepeval huggingface dataset:
Antimalarial activity of novel derivatives of primaquine (1981)

Journal Article Antimalarial activity of novel derivatives of primaquine Get access P. Pirson, P. Pirson ICP, 74 Avenue Hippocrate, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar R. F. Steiger, R. F. Steiger ICP, 74 Avenue Hippocrate, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Baurain, R. Baurain ICP, 74 Avenue Hippocrate, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Masquelier, M. Masquelier ICP, 74 Avenue Hippocrate, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Trouet A. Trouet ICP, 74 Avenue Hippocrate, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 75, Issue 1, 1981, Page 188, https://doi.org/10.1016/0035-9203(81)90080-8 Published: 01 January 1981
Variation in the Utilization of Postoperative Computed Tomography for Patients With Nonsyndromic Craniosynostosis: A National Claims Analysis (2019)

Over a quarter of patients underwent head CTs following reconstruction, and provider factors accounted for a large percentage of the variation. Given the risks of radiation, neurosurgeons and craniofacial surgeons face a critical need to establish postoperative imaging protocols to reduce unnecessary imaging in these vulnerable patients.
ChemInform Abstract: Greener Approach for the Synthesis of Substituted Alkenes by Direct Coupling of Alcohols with Styrenes Using Recyclable Broensted Acidic [NMP]+HSO4‐ Ionic Liquid (2014)

Abstract the ionic liquid, which acts both as a catalyst and solvent, is recyclable and reusable up to 5 times with only a slight decline in yield
Guidelines for the Development and Incorporation of Biomarker Studies in Early Clinical Trials of Novel Agents (2010)

The National Cancer Institute (NCI) Investigational Drug Steering Committee (IDSC) charged the Biomarker Task Force to develop recommendations to improve the decisions about incorporation of biomarker studies in early investigational drug trials. The Task Force members reviewed biomarker trials, the peer-reviewed literature, NCI and U.S. Food and Drug Administration (FDA) guidance documents, and conducted a survey of investigators to determine practices and challenges to executing biomarker studies in clinical trials of new drugs in early development. This document provides standard definitions and categories of biomarkers, and lists recommendations to sponsors and investigators for biomarker incorporation into such trials. Our recommendations for sponsors focus on the identification and prioritization of biomarkers and assays, the coordination of activities for the development and use of assays, and for operational activities. We also provide recommendations for investigators developing clinical trials with biomarker studies for scientific rationale, assay criteria, trial design, and analysis. The incorporation of biomarker studies into early drug trials is complex. Thus the decision to proceed with studies of biomarkers should be based on balancing the strength of science, assay robustness, feasibility, and resources with the burden of proper sample collection on the patient and potential impact of the results on drug development. The Task Force provides these guidelines in the hopes that improvements in biomarker studies will enhance the efficiency of investigational drug development.
Simple Techniques to Show the Distribution of Colloidal Gold 198 in Body Cavities (1957)

The injection of radioactive colloidal gold into the pleural and peritoneal cavities for the palliative treatment of effusions is now well established. After the 198Au has been injected it is very desirable to demonstrate that the radioactivity has spread throughout the effusion. It is always possible that the injection needle may not have penetrated into the cavity or that the cavity itself may be loculated so that the radioactive fluid cannot disperse. If the colloid remains at the point of injection then not only will there be a localised overdose to part of the mucosa, but the treatment is less likely to be effective. It is customary in some hospitals for a simple scan of the abdomen or chest to be made with a well-collimated Geiger counter with a scaler or rate-meter (Walton and Sinclair, 1952). It has been found here, however, that although this method is effective it suffers from practical disadvantages in that it is time consuming and, if an automatic device is not available, an appreciable radiation dose may be delivered to the operator. Also the equipment is heavy and inconvenient to carry to the ward and is usually mains-operated. This note presents a simple autoradiographic method of achieving the desired aim and also a cheap, portable, battery-operated monitor to measure the surface dose-rate or to carry out a scan.
Life cycle analysis of corn‐stover‐derived polymer‐grade l‐lactic acid and ethyl lactate: greenhouse gas emissions and fossil energy consumption (2016)

Abstract Co‐production of high‐value chemicals with biofuels could improve the economic viability of biorefineries while reducing biofuel life‐cycle greenhouse gas ( GHG ) emissions and fossil energy consumption ( FEC ). Polymer‐grade lactic acid ( PGLA ) is a high‐potential bioproduct currently produced from first‐generation feedstocks. Opportunity exists to enhance its environmental performance using cellulosic feedstocks. Moreover, ethyl lactate can be used as a functional replacement for high‐volume, energy‐intensive, and emissions‐intensive petroleum‐derived chemicals such as N‐methyl‐2‐pyrrolidone and ethyl acetate. Based on material and energy flows from Aspen Plus process models that we incorporated into the Greenhouse gases, Regulated Emissions, and Energy use in Transportation ( GREET ) model's bioproducts module, we developed life‐cycle GHG emissions and FEC estimates for ethyl lactate and PGLA produced from corn stover. We compared these results to those for fossil‐fuel‐derived counterparts, identified key LCA drivers, and explored the impact of end‐of‐life assumptions on LCA results. Irrespective of the end‐of‐life assumption, all the bioproducts demonstrated lower life‐cycle FEC (10–72%) and GHG emissions (23–90%) than fossil‐derived compounds for which they could serve as a functional replacement. Additionally, we reviewed the role of LCA in three major bioproduct sustainability certification schemes (the BioPreferred Program, the Roundtable on Sustainable Biomaterials, and International Sustainability and Carbon Certification Plus). None mandate an LCA of the bioproduct to assess whether, across the supply chain, these products offer environmental benefits as compared to conventional chemicals they could displace either directly or functionally. © 2016 Society of Chemical Industry and John Wiley &amp; Sons, Ltd
A new path-oriented effect-cause methodology to diagnose delay failures (2002)

A new methodology to diagnose delay failures is described. Key characteristics of the methodology are: (a) path-oriented diagnosis, (b) effect-cause reasoning, and (c) utilization of information obtained from the passing vectors. Two new representations are developed to make manageable the complexity of a path-oriented methodology. The results of diagnosis are: (a) proven to include all possible causes of observed delay errors, and (b) empirically found to have very high resolution.
Use of a Novel, Stable Gene Silencing Technology to Determine the Contribution of the Receptor Tyrosine Kinase to the Breast Cancer Phenotype (2004)

Abstract : An enormous amount of evidence has implicated members of the receptor protein tyrosine kinase (RPTK) family in many types of cancer. We have developed an extraordinarily powerful technique that uses small, DNA-encoded RNAs to suppress the expression of a desired gene in mammalian cells. For this project, short hairpin RNAs targeting each of the 58 human receptor protein tyrosine kinases will be created, introduced into MCF-7 cells and tested for effects on tumorigenicity in vivo and in vitro. At the end of the initial twelve months of the project there has been good progress. The goal of year one was to create a set of encoded hairpins targeted against the genomic complement of RPTKs. This goal has been met. By adopting high-throughput approaches to the construction of hairpins we have created a set of silencing agents not only for the genomic complement of receptor tyrosine kinases, but also all tyrosine kinases and a large number of genes functionally related to the RPTKs. Other developments include the use of shRNAs in the production of transgenic animals and microarray-based shRNA delivery for phenotypic screening. Both of these are potentially useful in future studies of the tyrosine kinase targeting constructs.
Observations of the Askaryan Effect in Ice (2007)

We report on observations of coherent, impulsive radio Cherenkov radiation from electromagnetic showers in solid ice. This is the first observation of the Askaryan effect in ice. As part of the complete validation process for the ANITA experiment, we performed an experiment at the Stanford Linear Accelerator Center in June 2006 using a 7.5 metric ton ice target. We measure for the first time the large-scale angular dependence of the radiation pattern, a major factor in determining the solid-angle acceptance of ultrahigh-energy neutrino detectors.
Ferromagnetic nanomaterials obtained by thermal decomposition of ferrocene in a closed chamber (2007)

Our investigation focused on the influence of the decomposition temperature, the work atmosphere (including organic-solvent vapor, water vapor, the presence or lack of reactive gases), the temperature-change rate, the process duration, and the influence of additional thermal treatments of the end materials. According to the conditions, Fe{sub 3}C, Fe{sub 3}O{sub 4}, and pure {alpha}-Fe particles have been created. Their composition and structure have been studied by Moessbauer spectroscopy, TEM, SEM, EPXMA and EDX. In a tightly closed chamber, all components obtained during the decomposition process remain there. This difference to the widely-used CVD method is very important. It inhibits the decomposition process and the growth of ordered structures, preventing the end materials to be separated from each other. During the process, the iron is liberated from the ferrocene molecule. Experiments have shown that it is highly chemically active to carbon and oxygen. For example, creation of carbide occurs in conditions that are not allowed according to the iron-carbon phase diagram valid for bulk iron. Water vapor has shown abnormal behaviour as well. Parallel to the reaction of iron with oxygen or carbon (according to the work atmosphere), the rest of the carbon and hydrogen atoms form a hydrocarbon substance, which covers the iron end product. This hydrocarbon cover is thermally and chemically resistant. Therefore, it can be used as a protection. During the syntheses, it also holds the particles together, building hollow agglomerations of different shapes (spherical, cylindrical, etc.). These are large structures with thin walls. In some experiments, even ideal hydrocarbon spheres without any iron products have been observed. When the chamber is kept at the ferrocene decomposition temperature, the particles with the highest load of {alpha}-Fe iron and the smallest sizes have been obtained. Increasing the temperature, especially in the presence of an organic solvent vapor, stimulates the iron to form carbide. The presence of water vapor or oxygen leads to iron oxides. Keeping high temperatures for longer periods of time increases the possibility of iron products to crystallize in highly symmetrical structures. The most common shape observed is cubical with cones growing at the sides. The ferromagnetic particles promise to be very useful due to their very small sizes and chemical resistance. They can be used for transport or extraction of substances from liquids, for local heating of living organisms, for changing of the liquid viscosity by magnetic fields, etc. (authors)
ChemInform Abstract: 1,10‐Dimethyl‐1,4,7,10,13,16‐hexaazacyclooctadecane L and 1,4,7‐ Trimethyl‐1,4,7,10,13,16,19‐heptaazacyclohenicosane L1: Two New Macrocyclic Receptors for ATP Biding. Synthesis, Solution Equilibria and the Crystal Structure of (H4L)(ClO4)4. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Statement on the Diagnosis and Management of Cyclic Vomiting Syndrome (2008)

Cyclic vomiting syndrome (CVS) is a disorder noted for its unique intensity of vomiting, repeated emergency department visits and hospitalizations, and reduced quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. Because no accepted approach to management has been established, the task force was charged to develop a report on diagnosis and treatment of CVS based upon a review of the medical literature and expert opinion. The key issues addressed were the diagnostic criteria, the appropriate evaluation, the prophylactic therapy, and the therapy of acute attacks. The recommended diagnostic approach is to avoid "shotgun" testing and instead to use a strategy of targeted testing that varies with the presence of 4 red flags: abdominal signs (eg, bilious vomiting, tenderness), triggering events (eg, fasting, high protein meal), abnormal neurological examination (eg, altered mental status, papilledema), and progressive worsening or a changing pattern of vomiting episodes. Therapeutic recommendations include lifestyle changes, prophylactic therapy (eg, cyproheptadine in children 5 years or younger and amitriptyline for those older than 5), and acute therapy (eg, 5-hydroxytryptamine receptor agonists, termed triptans herein, as abortive therapy, and 10% dextrose and ondansetron for those requiring intravenous hydration). This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the diagnosis and treatment of CVS in children and adolescents.
Synthesis of organic semiconductors functionalized with biological molecules (2010)

Organic polymeric and molecular semiconductors functionalized with biological molecules represent a very interesting class of materials for highly selective electrical and optical sensors. Molecular design and synthetic approaches to several bio-substituted conjugated oligomers and polymers are discussed, highlighting the impact of synthetic pathways on the properties of the materials.
Germanium Telluride Chalcogenide Switches for RF Applications (2021)

This project developed prototype germanium telluride switches, which can be used in RF applications to improve SWAP (size, weight, and power) and signal quality in RF systems. These switches can allow for highly reconfigurable systems, including antennas, communications, optical systems, phased arrays, and synthetic aperture radar, which all have high impact on current National Security goals for improved communication systems and communication technology supremacy. The final result of the project was the demonstration of germanium telluride RF switches, which could act as critical elements necessary for a single chip RF communication system that will demonstrate low SWAP and high reconfigurability.
ChemInform Abstract: (Supra)Molecular Systems Based on Crown Ethers and Secondary Dialkylammonium Ions (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo (2022)

Transcriptional regulator BCL11A plays a crucial role in coordinating a suite of developmental processes including skin morphogenesis, barrier functions and lipid metabolism. There is little or no reports so far documenting the role of BCL11A in postnatal adult skin homeostasis and in the physiological process of tissue repair and regeneration. The current study establishes for the first time the In Vivo role of epidermal BCL11A in maintaining adult epidermal homeostasis and as a negative regulator of cutaneous wound healing. Conditional ablation of <i>Bcl11a</i> in skin epidermal keratinocytes (<i>Bcl11a<sup>ep-/-</sup></i>mice) enhances the keratinocyte proliferation and differentiation program, suggesting its critical role in epidermal homeostasis of adult murine skin. Further, loss of keratinocytic BCL11A promotes rapid closure of excisional wounds both in a cell autonomous manner likely via accelerating wound re-epithelialization and in a non-cell autonomous manner by enhancing angiogenesis. The epidermis specific <i>Bcl11a</i> knockout mouse serves as a prototype to gain mechanistic understanding of various downstream pathways converging towards the manifestation of an accelerated healing phenotype upon its deletion.
Plan B (2011)

"Would someone please turn off that alarm?" asked Lieutenant Raleigh. "I can't concentrate!"KeywordsSolar CollectorMartian AtmosphereDeep BreathMeteor ShowerBackup PowerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Synaptic maturation of cultured hippocampal neurons from fragile‐X mice (2006)

Fragile X syndrome (FXS) is usually caused by transcriptional silencing of the FMR1 gene, which encodes the fragile X mental retardation protein (FMRP). The “mGluR theory” of FXS suggests that key aspects of the syndrome are caused by exaggerated signaling by group 1 metabotropic glutamate receptors (mGluRs). A prediction of the theory is that some rescue could be achieved by down‐regulating mGluRs, either pharmacologically or genetically. We have studied the maturation of excitatory synapses in hippocampal cultures prepared from Fmr1 knockout (KO) and wild‐type (WT) mice with the aim of testing this prediction. Findings to date indicate that dendrites of neurons lacking FMRP have a significantly higher density of GluR2 and synapsin puncta than controls. GluR2 puncta per 10 μm measured 7.0 ± 1.4 in WT (n = 4) and 11.1± 0.8 in KO (n = 7) neurons (P = 0.04). Similarly, synapsin puncta per 10 μm measured 7.2 ± 1.1 in WT (n = 5) and 11.7 ± 0.9 in KO (n = 10) neurons (P = 0.017). We also find that synaptic GluR2 expression is differentially affected by transient activation of mGluRs with DHPG (100 μM) in WT and KO neurons. DHPG treatment produces significant loss of synaptic GluR2 in cultures from KO (43 ± 6 % of untreated controls), but not WT animals (100 ± 20 % of untreated controls). Experiments are currently underway to see if chronic treatment of the cultures with MPEP, an mGluR antagonist, can rescue these phenotypes. Supported by HHMI, NIH, and FRAXA.
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy (2018)

Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been challenging, thus hindering the identification of effective therapeutics. Here, we report the generation of isogenic induced pluripotent stem cells carrying wild-type and P525L FUS-eGFP. We demonstrate that FUS-eGFP is recruited into SGs and that P525L profoundly alters their dynamics. With a screening campaign, we demonstrate that PI3K/AKT/mTOR pathway inhibition increases autophagy and ameliorates SG phenotypes linked to P525L FUS by reducing FUS-eGFP recruitment into SGs. Using a Drosophila model of FUS-ALS, we corroborate that induction of autophagy significantly increases survival. Finally, by screening clinically approved drugs for their ability to ameliorate FUS SG phenotypes, we identify a number of brain-penetrant anti-depressants and anti-psychotics that also induce autophagy. These drugs could be repurposed as potential ALS treatments.
Plasma Osmolality and Brain Water Content in a Rat Glioma Model (1994)

Little is known about how intravenous fluids influence peritumoral edema formation. This experiment was designed to determine, in a rat glioma model, whether changes in plasma osmolality alter water content, as assessed by specific gravity (SpGr), in normal and neoplastic cerebral tissue. Cells cultured from an ethylnitrosourea-induced rat glioma were stereotactically implanted into the right striatum of Fischer 344 rats. A tumor growth interval of 21 days was allowed. In a second experiment, rats underwent a 60-second cortical freeze injury followed by 24 hours' recovery. In both experiments, rats were assigned to one of three groups: hypotonic (100 ml/kg of 0.2 mol/L NaCl in H2O, intraperitoneally; resultant plasma osmolality approximately 268 mOsm/kg); isotonic (no treatment; plasma osmolality approximately 298 mOsm/kg); or hypertonic (10 ml/kg of 1.0 mol/L NaCl in H2O, intraperitoneally; plasma osmolality approximately 342 mOsm/kg). Thirty minutes after fluid injection, regional SpGr was determined using a kerosene-bromobenzene gradient. In subsets of rats, the tissue morphology and blood-brain barrier permeability of Evans blue dye were assessed. Tissue within the freeze lesion was stained by Evans blue dye with sharp demarcation. Evans blue dye did not stain gliomatous tissue, and central necrosis was not histologically evident. In isotonic rats, glioma SpGr was reduced (1.0411 +/- 0.0012 g/ml) relative to the contralateral striatum (1.0437 +/- 0.0008 g/ml; P < 0.001). Despite this, a strong linear relation was observed for SpGr and plasma osmolality in both neoplastic and normal tissue. Within the freeze lesion in isotonic rats, SpGr was severely reduced (1.0335 +/- 0.0008 g/ml; P < 0.0001) compared with contralateral frontal cortex.(ABSTRACT TRUNCATED AT 250 WORDS)
Investigation of compatibility in syndiotactic poly(methyl methacrylate)/poly(vinyl chloride) blends (1985)

peer reviewed
Recursive total least squares algorithm for single-user blind channel equalisation (2000)

The problem of blind channel identification/equalisation using second-order statistics or equivalent deterministic properties of the oversampled channel output has attracted considerable attention. Deterministic blind subspace algorithms are particularly attractive because of their finite sample convergence property and because their solution can be obtained in closed form. Most subspace algorithms developed up until now, however, are based on block processing and have high computational and memory requirements. In the paper, adaptive techniques are used to lower the computational burden. A single-user direct symbol estimation algorithm is presented. The first step in the algorithm consists of an adaptive matrix singular value decomposition for a (virtual) channel identification-type operation. A recursive total least squares algorithm is then used to recover the input symbols. The algorithm is able to track time-varying channels.