gebhart/patrepeval huggingface dataset:
Mechanical stimulation promotes the proliferation and the cartilage phenotype of mesenchymal stem cells and chondrocytes co-cultured in vitro (2019)

Mesenchymal stem cells and chondrocytes are an important source of the cells for cartilage tissue engineering. Therefore, the culture and expansion methods of these cells need to be improved to overcome the aging of chondrocytes and induced chondrogenic differentiation of mesenchymal stem cells. The aim of this study was to expand the cells for cartilage tissue engineering by combining the advantages of growing cells in co-culture and under a mechanically-stimulated environment. Rabbit chondrocytes and co-cultured cells (bone mesenchymal stem cells and chondrocytes) were subjected to cyclic sinusoidal dynamic tensile mechanical stimulationusing the FX-4000 tension system. Chondrocyte proliferation was assayed by flow cytometry and CFSE labeling. The cell cartilage phenotype was determined by detecting GAG, collagen II and TGF-β1 protein expression by ELISA and the Col2α1, TGF-β1 and Sox9 gene expression by RT-PCR. The results show that the co-culture improved both the proliferation ability of chondrocytes and the cartilage phenotype of co-cultured cells. A proper cyclic sinusoidal dynamic tensile mechanical stimulation improved the proliferation ability and cartilage phenotype of chondrocytes and co-cultured cells. These results suggest that the co-culture of mesenchymal stem cells with chondrocytes and proper mechanical stimulation may be an appropriate way to rapidly expand the cells that have an improved cartilage phenotype for cartilage tissue engineering.
‘Babesia gibsoni’ of dogs from North America and Asia belong to different species (2000)

18S rDNA sequences from 4 isolates of Babesia gibsoni originating from Japan, Malaysia and Sri Lanka were compared with a previously published, 0·5 kb portion of the 18S rDNA from a B. gibsoni isolate from California, USA, and with the corresponding 18S rDNA sequences of other Babesia spp. Distance, parsimony and maximum likelihood analyses showed almost identical genotypes among the small canine Babesia from Asia, but an unexpectedly distant genetic relationship to that from the USA. While the American isolate segregated together with B. equi, the Asian isolates showed a close relationship to B. divergens and B. odocoilei. These results indicate that small Babesia of dogs originating from North America and Asia belong to different, genetically distantly related species.
Supplementary Data from First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis (2023)

Supplementary Data from First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis
PREMIS-Lite, a Preservation Metadata Generator (2014)

Digital preservation is without question an important, if not essential, facet of our now digital society. Implementing a digital preservation strategy is crucial to ensuring the longevity and sustained usability of digital content. The importance of digital preservation is not limited to large-scale institutions and organizations, but also extends to private individuals and small-scale businesses. PREMIS is currently the international preservation metadata standard. The objective of PREMIS was to identify and create a wide ranging and implementable set of "core" preservation metadata elements while following the recommendations of the Open Archival Information System (OAIS) reference model. However, the depth and complexity of that coverage can be confusing and discourage its potential use. Using the PREMIS standard as a model this project creates a “PREMIS-Lite” xml preservation metadata generator. This PREMIS-Lite XML generator and its supporting PREMIS-Lite semantic unit definition, user guide, and crosswalk combine to allow for the simple capture and creation of preservation metadata at the object level.
Vinylogy in nitronates: utilization of α-aryl conjugated nitroolefins as a nucleophile for a highly stereoselective aza-Henry reaction (2015)

Vinylogous nitronates generated from α,β-disubstituted nitroolefins undergo stereoselective bond formation with aldimines at the sterically encumbered α-position, establishing contiguous tertiary–quaternary stereocenters.
Thyroid Hormone Receptor β (THRB) Is a Major Target Gene for MicroRNAs Deregulated in Papillary Thyroid Carcinoma (PTC) (2010)

MiRs up-regulated in PTC tumors directly inhibit the expression of THRB, an important tumor suppressor gene.
A Cluster of ABA-Regulated Genes onArabidopsis thalianaBAC T07M07 (1999)

Arabidopsis thaliana BAC T07M07 encoding the abscisic acid-insensitive 4 (ABI4) locus has been sequenced completely. It contains a 95,713-bp insert and 24 predicted genes. Most putative genes were confirmed by gel-based RNA profiling and a cluster of ABA-regulated genes was identified. One of the 24 genes, designated PP2C5, encodes a putative protein phosphatase 2C. The encoded protein was expressed in Escherichia coli, and its enzyme activity in vitro was confirmed.
Preserved visuoconstruction in patients with Alzheimer's pathology and anti-neural autoantibodies: A case control study (2022)

Our pilot findings are encouraging us to conduct large-scale studies to replicate our discovery of preserved visuoconstruction in AP Aab+ patients with hippocampus-based memory dysfunction. The role of anti-neural autoantibodies is still not fully understood. The detection of these autoantibodies might imply another disease pathology that could be either neuroprotective or be affecting other brain regions, i.e., less pronounced disease activity in the right temporo-parietal regions mainly involved in visuoconstruction.
Tunneling selection of optical vortices (2003)

We have studied the process of separation of the dominant mode and guided vortices in a Y-shaped directional fiber beam splitter. It is shown that, under certain conditions, the dominant mode field is completely pumped to the second channel, leaving the optical vortex field in this channel unchanged. Based on such a splitter, a vortex fiber interferometer has been created and characterized with respect to linearity and temperature sensitivity.
Optical fiber system for video and telemetry signal transmission (2002)

A cost effective optical fiber system for transmission of video and telemetry signal (2 Mbps) in one direction and command signal (2 Mbps) in the other has been designed and developed. The optical fiber system using single mode optical fiber and semiconductor lasers operates at 1550 nm and 1300 nm wavelength full-duplex mode through optical Wavelength Division Multiplexer (WDM)/Bidirectional couplers. Pulse-Frequency-Modulation/Optical Intensity Modulation PFM/IM is adopted for the transmission of video signal while the transmission of telemetry signal adopts the Frequency-Shift-Keying FSK/IM technique. The system developed achieves a data bit error rate of better than 10/sup -10/ and video signal-to-noise ratio of 48 dB for a transmission span of above 3 km with very good system margin. A computer simulation program for evaluation of optical fiber data transmission system performance was adopted in the system development.
UNE REMARQUE SUR LA FORMULE DU CHANGEMENT DE VARIABLES DANS Rn (2004)

The aim of this paper is to give a result which generalizes the usual change of variables formula in euclidean spaces.
프랑스 지역학 / 언어학 / 웹 ( Web ) 을 활용한 프랑스어와 문화 학습 (2000)

Avec le dveloppement du reseau Internet et de son standard d`criture Html, on peut dire que 1`ensemble des applications d`information ou d`enseignement est bash actuellement sur le Principe de 1`hypermedia `Web`. Cette mthode de construction, associe aux outils classiques de realisation d`hypertexte devrait permettre dobtenir des hypermedias avec une structure moms complexe et plus efficace. Done, les applications p~dagogique futures seront construites sur le Principe de 1`hypermdia `Web`. Une application hypermedia `Web` se caracterise par 1`association des specificites de 1`hypertexte et du multimedia. De part sa structure hypertextuelle, le Web sera bash sur une navigation de 1`utilisateur dans un rseau de donnes relies entre eux par simple clic la souris. Ce concept dveloppe ces dernires annexes par 1$quot;adjonction des possibilits multimrsdias des nouveaux matriels informatiques. Ainsi, il est devenu possible d`intgrer des sequences provenant de diffrents supports (images firs ou animes, sons, videos) 1`intrieur mime de 1`hypertexte. qui est devenu, de ce fait un hypermedia. On peut expliquer le succs de ce type de presentation, par la facility et la conviviality d`utilisation, mais surtout par la rapidity avec laquelle, il est possible de slctionner et d`acceder une information. En effet, les aspects de 1$quot;interactivity et de la participation de 1`apprenant la sequence educative peuvent tre actuellement considrs comme prformants (notamment avec les nouvelles possibilitess de traitements de rponses du standard Html). Si 1`on veut rendre les hypermdias plus efficaces pdagogiquement, il parait ncessaire d$quot;apprendre utiliser un hypermedia ou tre efficace sur le Web. La meilleur mani8re de rendre efficace 1`utilisation de ce genre d`application reside pour les concepteurs a ne pas se contenter d`informatiser des donnes, mais plutot construire un rseau de liens permettant, en plus de la transmission de connaissances, de dwelopper les facults intellectuelles de 1`utilisateur. Nous pensons que cette augmentation de 1`efficacit des hypermdias est directement lie 1`accentuation des possibilits de travail autonome et surtout aux attitudes actives des professeurs et des tudiants quant aux quantits d`informations. Comme nous 1`avons vu, les caractristiques du Web`(hypertexte et multimedia) nous permettent de montrer les plusieurs aspects de la culture franaise et de transmettre une image reelle de la France ($quot;`pays de fart$quot; et en meme temps `$quot;pays de la technique$quot;$quot;). Et puffs, le `Web` nous permette de transmettre les informations rcents de la France plus raidement aux gens qui s`intressent la culture franaise et d`apprendre le franais aux tudiants avec plusieurs mthodes de multimedia.
The spectral response of BSF silicon solar cells fabricated through masked ion implantation (1983)

The work presents the main peculiarities of the spectral response of back-surface-field (BSF) silicon solar cells fabricated through masked ion implantation of the n+-p junction. The emphasis is on the shift of maximum responsivity toward the visible spectrum and on the large bandwidth of these n+-p-p+ optical sensors. The dependence of these parameters on technological parameters are outlined in the communication.
Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-.ANG. resolution (1993)

Kanamycin nucleotidyltransferase, as originally isolated from Staphylococcus aureus, inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside. The molecular structure of the enzyme described here was determined by X-ray crystallographic analysis to a resolution of 3.0 A. Crystals employed in the investigation belonged to the space group P4(3)2(1)2 with unit cell dimensions of a = b = 78.9 A and c = 219.2 A. An electron density map phased with seven heavy-atom derivatives revealed that the molecules packed in the crystalline lattice as dimers exhibiting local 2-fold rotation axes. Subsequent symmetry averaging and solvent flattening improved the quality of the electron density such that it was possible to completely trace the 253 amino acid polypeptide chain. Each monomer is divided into two distinct structural domains: the N-terminal motif composed of residues Met 1-Glu 127 and the C-terminal half delineated by residues Ala 128-Phe 253. The N-terminal region is characterized by a five-stranded mixed beta-pleated sheet whereas the C-terminal domain contains five alpha-helices, four of which form an up-and-down alpha-helical bundle very similar to that observed in cytochrome c'. The two subunits wrap about one another to form an ellipsoid with a pronounced cleft that could easily accommodate the various aminoglycosides known to bind to the enzyme.
Behavior of forged S-816 turbine blades in steady-state operation of J33-9 turbojet engine with stress-rupture and metallographic evaluations (1953)

An investigation was conducted to determine the behavior of recently produced, forged S-816 turbine blades in a full-scale turbojet engine, and in particular, the scatter in performance of the alloy. The turbine blades were operated as continuously as possible at a temperature of 1500 degrees F and a centrifugal stress of 21,500 pounds per square inch. The operating lives of the turbine blades varied from 181 to 539 hours, a range of 358 hours. Stress-rupture properties of specimens cut from blade airfoils also varied considerably, as much as 1257 hours at 20,000 pounds per square inch and 1500 degrees F. Since the variability of scatter of stress-rupture data is greater than that of blade performance, the scatter is probably caused by variations in the properties of the forged blades rather than by variations caused by engine operation or installation of the blades. Metallographic examinations were made to determine possible causes of the scatter and although numerous differences in microstructures of blades were found, no consistent tendencies were observed and the findings did not permit an explanation of the scatter of blade performance. The results of the metallographic examinations and of the physical tests indirectly indicated variables in the fabricating method caused the scatter in properties.
Evaluation of flow battery technology : an assessment of technical and economic feasibility (2009)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2009.
2D lagrangian code "ATLANT-HE" for simulation of laser-plasma interaction with allowance for hot electron generation and transport (2003)

Hot electrons may significantly influence interaction of ultra short laser pulses with solids. Accurate consideration of resonant absorption of laser energy and hot electrons generation at a critical surface was achieved through the developed physical and mathematical models. 2D ray tracing algorithm has been developed to simulate laser beam refraction and Bremsstrahlung absorption with allowance for non-linear influence of a strong electromagnetic field. Hot electrons transport was considered as a straight-line flows weakening by a friction force calculated in the approximation of the average state of ionization. Developed models were coupled with 2D Lagrangian gas dynamic code "ATLANT" that takes into account non-linear heat transport. The developed program has been applied to simulate irradiations of Al foils by picosecond laser double pulses. Hot electrons transport and heating resulted in thin foil explosions. The transition from exploding foil regime to the ablative one with foil thickening has been simulated and analyzed at various values of laser light intensity.
The responses of some Lepidoptera to labiate herb and white clover extracts (1985)

Abstract Herbs have been traditionally used as intercrops with crop plants on the assumption that their odour repels pest species. Alcohol extracts and essential oils of labiate herbs were tested in the laboratory for deterrent/repellent responses to ovipositing Plutella xylostella (L.) and feeding larvae of P. xylostella and Pieris brassicae L. Alcohol extracts of hyssop, rosemary, sage, thyme and white clover reduce oviposition by P. xylostella on pieces of brassica leaf in dual‐choice tests. Essential oils of sage and thyme reduce oviposition on pieces of brassica leaf. Feeding, in dual‐choice tests, by final instar P. xylostella and P. brassicae larvae is reduced by application of alcohol extracts of herbs. RÉSUMÉ Résponses de quelques lepidopteres a des labiées médicinales et à des extraits de trèfle blanc Des plantes médicinales ont traditionnellement été utilisées en association avec des plantes cultivées dans l'espoir que leur odeur repousserait les insectes nuisibles. Des extraits à l'alcool et des essences volatiles de labiées médicinales ont été essayés au laboratoire pour examiner leur effets répulsif et dissuadant pour la ponte de Plutella xylostella et l'alimentation des chenilles de P. xylostella et Pieris brassicae . Les extraits alcooliques d'hysope, de romarin, de sauge, de thym et de trèfle blanc réduisent la ponte de P. xylostella sur des morceaux de feuilles de chou traitées. Les essences volatiles de sauge et de thym réduisent la ponte de P. xylostella sur des morceaux de feuilles de chou dans des expériences de choix. L'alimentation des chenilles de dernier stade de P. xylostella et P. brassicae dans des expériences de choix est réduite par l'application d'extraits alcooliques des labiées médicinales.
Synthesizing animatable body models with parameterized shape modifications (2003)

Based on an existing modeller that can generate realistic and controllable whole-body models, we introduce our modifier synthesizer for obtaining higher level of manipulations of body models by using parameters such as fat percentage and hip-to-waist ratio. Users are assisted in automatically modifying an existing model by controlling the parameters provided. On any synthesized model, the underlying bone and skin structure is properly adjusted, so that the model remains completely animatable using the underlying skeleton. Based on statistical analysis of data models, we demonstrate the use of body attributes as parameters in controlling the shape modification of the body models while maintaining the distinctiveness of the individual as much as possible.
Exclusion in the semiconductor p+-p-p+structure under conditions of a temperature gradient (1998)

The paper presents theoretical and experimental investigations of the exclusion and accumulation effects in rectangular p+-p-p+ structures with a homogeneously doped p-region under conditions of a temperature gradient along its base. It is shown that the temperature gradient causes a strong asymmetry of properties, such as current-voltage characteristics, distributions of non-equilibrium carriers and electric field, with regard to polarity of the voltage drop across the base. The results obtained can be useful for the technology of infrared devices working at room temperature as well as for sensors sensitive to the polarity of an electric field.
4D maximuma posteriorireconstruction in dynamic SPECT using a compartmental model-based prior (2001)

A 4D ordered-subsets maximum a posteriori (OSMAP) algorithm for dynamic SPECT is described which uses a temporal prior that constrains each voxel's behaviour in time to conform to a compartmental model. No a priori limitations on kinetic parameters are applied; rather, the parameter estimates evolve as the algorithm iterates to a solution. The estimated parameters and time-activity curves are used within the reconstruction algorithm to model changes in the activity distribution as the camera rotates, avoiding artefacts due to inconsistencies of data between projection views. This potentially allows for fewer, longer-duration scans to be used and may have implications for noise reduction. The algorithm was evaluated qualitatively using dynamic 99mTc-teboroxime SPECT scans in two patients, and quantitatively using a series of simulated phantom experiments. The OSMAP algorithm resulted in images with better myocardial uniformity and definition, gave time-activity curves with reduced noise variations, and provided wash-in parameter estimates with better accuracy and lower statistical uncertainty than those obtained from conventional ordered-subsets expectation-maximization (OSEM) processing followed by compartmental modelling. The new algorithm effectively removed the bias in k21 estimates due to inconsistent projections for sampling schedules as slow as 60 s per timeframe, but no improvement in wash-out parameter estimates was observed in this work. The proposed dynamic OSMAP algorithm provides a flexible framework which may benefit a variety of dynamic tomographic imaging applications.
Promote HIV Chemoprophylaxis Research, Don't Prevent It (2005)

Preexposure chemoprophylaxis (PrEP) is a promising approach to HIV-1 prevention that warrants clinical evaluation, especially in regions of the world hit hardest by the epidemic. Controversy has arisen that highlights the needs of high-risk populations who frequently have limited access to information and medical care. The authors of this
 Policy Forum
 recommend involvement of community leaders and local investigators early in the development of research projects, open communication of accurate information about research, and active development of prevention and treatment infrastructure, which all serve to build the community trust that is the basis for research into finding ways to stop the spread of HIV/AIDS.
Rinderwürmer werden resistent (2011)

Um Weidetiere vor Endoparasiten zu schützen, greift man meist zu Entwurmungsmitteln. Mit folgen: Während ein großer Teil der Magen- und Darm-Würmer bei Schafen und Ziegen schon lange gegen bestimmte Wirkstoffe resistent ist, tauchen nun auch bei Rinderwürmern erste Resistenzen auf.
Follow-up study to prove the prognostic value of P-53, S-100-??, ICAM-1 and 5-S-cysteinyldopa in serum of patients with malignant melanoma (1997)

Stockfleth, E; Meyer, T1; DammY, ; Heckmann, O; Christophers, A E; Hauschild, A Author Information
Erratum: Giant Acoustic Concentration by Extraordinary Transmission in Zero-Mass Metamaterials [Phys. Rev. Lett.110, 244302 (2013)] (2013)

Received 14 October 2013DOI:https://doi.org/10.1103/PhysRevLett.111.199901© 2013 American Physical Society
Automatic knowledge acquisition for an expert system for distillation control (1988)

A process continuously produces data about the state of its variables. Knowledge about the process is embodied in these data. If data representing stable and recovery states are selectively used to induce and refine rules, these rules will contain the best knowledge of the operators and also knowledge intrinsically contained in the mathematical model of the process control computer. A system is presented which acquires knowledge about an industrial process in the form of rules about how monitored variables can be related to controlled variables to produce stability in dependent variables. The system uses a genetic rule induction algorithm on data specifically selected to contain knowledge about the setting of controlled variables.
Experimental study on performance of two types of corrugated plate gas-liquid separators (2017)

The performance of corrugated plate gas-liquid separators with streamlined plates and streamlined plates with hook was carried out by experiment. Overall and grade separation efficiencies of water droplets by Promo 3000 aerosol spectrometer and static pressure drops were investigated for two types of plates with 20 and 30 mm transverse pitch. The results show that the efficiency can be improved by increasing gas velocities and shortening transverse pitch while the optimal separation efficiency does not corresponds to the economic pressure drop. The grade efficiencies of fine droplets smaller than 4μm are abnormally high and the curve shows a fish-hook shape, which is also found in gas-solid separation.