gebhart/patrepeval huggingface dataset:
The roles of microRNA families in hepatic fibrosis (2017)

When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists of several miRNAs which have the potential for synergistic regulation of these signaling pathways. However, it is poor to understand the roles of miRNA family as a whole in hepatic fibrosis. Increasing studies have suggested several miRNA families are related with activation of hepatic stellate cells and hepatic fibrosis through cooperatively regulating certain signaling pathways. During the process of hepatic fibrosis, miR-29 family primarily induces cell apoptosis by modulating phosphatidylinositol 3-kinase/AKT signaling pathway and regulates extracellular matrix accumulation. miR-34 family promotes the progression of hepatic fibrosis by inducing activation of hepatic stellate cells, while miR-378 family suppresses the process in Glis dependent manner. miR-15 family mainly promotes cell proliferation and induces apoptosis. The miR-199 family and miR-200 family are responsible for extracellular matrix deposition and the release of pro-fibrotic cytokines. These miRNA family members play pro-fibrotic or anti-fibrotic roles by targeting genes collectively or respectively which involve in hepatic fibrosis related signaling pathways and hepatic stellate cell activation. Thus, good understandings of molecular mechanisms which are based on miRNA families may provide new ideas for the molecular targeted therapy of hepatic fibrosis in the future.
Albuminuria and sodiuria in IUGR children (2014)

Our results show glomerulosclerosis and albuminuria in IUGR children aged 18 months. Elevated sodium excretion in the absence of abnormal lysozymuria may represent a epiphenomenon of glomerulosclerosis and of albuminuria.
Use of the LMS adaptive signal processing technique to improve signal data rates from practical oil well logging equipment (1998)

The simulation and development work that has been undertaken to produce a signal equaliser used to improve the data rates from oil well logging instruments is presented. The instruments are lowered into the drill bore hole suspended by a cable which has poor electrical characteristics. The equaliser described in the paper corrects for the distortions that occur from the cable (dispersion and attenuation) with the result that the instrument can send data at 100 K.bits/second down its own suspension cable of 12 Km in length. The use of simulation techniques and tools were invaluable in generating a model for the distortions and proved to be a useful tool when site testing was not available.
Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-gamma (1999)

The purpose of this study was to localize intercellular adhesion molecule (ICAM)-1 and ICAM-2 in human endometrium and myometrium throughout the menstrual cycle, and to determine whether the expression of these molecules is regulated by interferon (IFN)-gamma. ICAM-1 and ICAM-2 distribution was examined in endometrial biopsies by immunocytochemistry, and Northern blotting was used to quantify ICAM-1 and ICAM-2 mRNA expression in isolated endometrial glands. Stromal fibroblast cultures were exposed to IFN-gamma and the effect on expression of ICAM-1 and ICAM-2 was determined by immunocytochemistry and Northern blotting. ICAM-1 was localized in vivo to the apical surface of the glandular epithelium, the vascular endothelium and endometrial stromal cells throughout the menstrual cycle. Stromal expression of ICAM-1 was up-regulated in menstrual specimens. Northern blotting confirmed the presence of ICAM-1 mRNA in isolated endometrial glands. The expression of ICAM-1 antigen and message was increased in stromal cell culture after incubation with IFN-gamma in a time-dependent manner, suggesting that this cytokine stimulates the expression of ICAM-1 in the endometrial stroma. ICAM-2 antigen expression was restricted to the vascular endothelium. ICAM-2 mRNA was absent in endometrial glands. The widespread distribution of ICAM-1 in human endometrium suggests that this molecule is involved in the process of menstruation, the functioning of glands, blood vessels and stroma, and in regulating leukocyte trafficking into the tissue. ICAM-2 is restricted to the vascular endothelium where it might modulate leukocyte invasion of the stroma and myometrial connective tissue.
Study of Groundwater Prediction on Manasi River Basin of Xinjiang (1999)

Temperature and precipitation inside the glacierized area are the major factors controlling groundwater formation in a glaciation valley The application of mechanism forecast model encounters difficulty for data shortage This paper is on the basis of the yearly runoff time series of the groundwater on Manasi River basin, and a combination model of yearly runoff time series for grondwater is established It is formed from tendency item, period item and the random series The model has a self adaptation function The model parameters can be rectified by increasing information and feedback This model is applied in the groundwater yearly runoff forecast in the Manasi River basin Forecast efficiency is satisfied
Editorial (2000)

I'm very pleased to have the opportunity to take over as editor-in-chief after Holly Rushmeier's strong leadership of the past three years. ACM has made a big effort to get TOG back on schedule after the delays caused by changing to a new publication system. With this issue, we are almost on schedule again and the backlog of accepted papers is significantly reduced. I hope to further shorten the time the return reviews to authors and to get accepted paper to readers. As part of that effort, I have asked Steve Fortune for Bell Labs, John Hart from Washington State, Joe Marks from MERL, and Jorg Peters from the University of Florida to be new members of the editorial board to replace those who retired with the end of Holly's term. I expect that we'll see significant changes in the role of journals during my three-year term. Right now, journals utilize peer reviews and a revision cycle to provide accreditation to research, but this process is tied to a particular distribution medium and requires financial support in the form of subscription fees. With the increasing use of web-baed publishing, I expect that the accreditation and distribution functions will begin to separate. Accreditation will continue to play an important role in scientific reputations and academic careers, while the publication media will become far more diverse. This diversification is particularly important for graphics because many of its important results are not represented well on paper. TOG has moved in this direction with a web page that is expertly maintained by Eric Haines and contains occasional supplemental material (http://www.acm.org./tog/). If TOG is to represent the true breadth of graphics, however, we will have to make much more of an effort in this direction. During the next three years, we will almost certainly see significant changes in graphics as well. Clearly, the field is expanding beyond the creation of beautiful and useful images and image sequences. New emphases include increasingly realistic physical modeling, interactive worlds, and nonvisual modalities. Graphics is a fascinating field, in part because researchers are able to adopt and adapt new ideas from so many other fields: art, vision, physics, materials science, control, optimization and biomechanics. I look forward to the innovative and creative work that the community will submit to TOG during the next three years.
Cath‐Finder‐TM Catheter Tracking System: a new device for positioning of central venous catheters. Early experience from implantation of brachial portal systems (1990)

To simplify the implantation procedure of a new brachially implantable venous access system (P.A.S. Port. Pharmacia Deltec Inc., St. Paul, MN, USA), the Cath-Finder Catheter Tracking System (Pharmacia Deltec) was evaluated. The Cath-Finder senses the catheter tip position by utilizing a preconnected sensor wire (guidewire) within a catheter to detect an electromagnetic signal transmitted through the body tissue from a locator wand positioned over an appropriate external landmark. The aim of the study was to evaluate the accuracy of the Cath-Finder (compared to fluoroscopy) in determining the catheter tip position peroperatively during implantation of P.A.S. Port systems in patients with malignant diseases. The accuracy of the Cath-Finder in assessing the position of the catheter tip was registered in 16 implantation procedures. The tip positions determined with the Cath-Finder (when projected on the skin) correlated well to fluoroscopy (within 1 cm in eleven patients, 2-3 cm in four patients, and 4 cm in one patient). By using the right 3rd rib parasternally as an external landmark for the locator wand, the Cath-Finder Catheter Tracking System appears to be an alternative to fluoroscopy peroperatively for accurate placement of central venous catheters in the superior vena cava. However, a postoperative confirmatory x-ray control is recommended until further experience of the system is available.
Exploring Feasibility for Application of Luminescent CdTe Quantum Dots Prepared in Aqueous Phase to Live Cell Imaging (2006)

This paper explored the feasibility for the application of luminescent CdTe quantum dots prepared in aqueous phase to live cell imaging. The highly luminescent CdTe quantum dots (QDs) were first prepared in aqueous phase, and then were covalently coupled to a plant lectin (UEA-1), as a fluorescent probe. After incubating with of human umbilical vein endothelial cells (HUVECs), the QD probe with UEA-1 was able to specifically bind the corresponding cell receptor. The good cell images were obtained in live cells using laser confocal scanning microscopy. We predict that QDs prepared in water phase will probably become an attractive alternative probe in cellular imaging and bio-labeling.
Maternal prenatal gut microbiota composition predicts child behaviour (2021)

This study was funded by the National Health and Medical Research Council of Australia (1082307, 1147980), Murdoch Children's Research Institute, Barwon Health and Deakin University.
Developmental Progress of Five Groups of Disabled Children Attending an Early Intervention Program (1987)

Developmental progress of 64 disabled children comprising five diagnostic groups was measured during intervention at an infant development program by means of an Intervention Efficiency Index (IEI). The index was then compared with admission developmental quotient (DQ) to determine acceleration, deceleration or maintenance of expected developmental progress. This ratio, the Proportional Change Index (PCI), is 1.0 in the case of children or groups who maintain their admission developmental status. Rates of progress of each group are discussed. Finally, independent variables which might be progress predictors were correlated with both the IEI and the PCI. Higher admission DQ and cognition developmental age and a younger admission chronological age were significantly correlated with greater developmental progress.
Radiation therapy for Ewing’s sarcoma (2005)

8555 Purpose: To evaluate the outcome of patients with Ewing’s sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques using MRI imaging along with optimal chemotherapy. Materials and Methods: The records of all 60 patients with ESFT who received radiation to the primary site at MSKCC between 1990 and 2004 were reviewed. All patients received chemotherapy including vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide with or without surgical resection. All patients had MRI and CT scan based treatment planning and 43% received intensity modulated radiation therapy (IMRT). Radiation doses ranged from 30–60 Gy, median 51 Gy. Hyperfractionation was used in 35% of patients. We analyzed outcome and the effect of potential prognostic factors. Follow-up of surviving patients is 6–178 (median 41) months. Results: Median age was 16 (2–40) years with a male:female ratio of 1.1:1. Because of selection bias for radiotherapy, the majority of tumors were in the axial skeleton: spine (18), pelvis (15), extremities (12), chest wall (5), head and neck (5), and other (5) with 78% arising in bone and 22% in soft tissue. Metastases were present at diagnosis in 38% of patients and 52% of primary tumors were ≥ 8 cm. Actuarial 3-year local control was 77%. Time to local failure ranged from 8 to 32 months. The presence of metastases at diagnosis was an adverse prognostic factor for local control, 84% vs. 62% (p=0.04). No other predictive factors for local failure were identified including patient age, tumor size and site, as well as radiation dose, timing, fractionation or whether it was definitive or postoperative. In patients without metastatic disease, 3-year disease-free and overall survival were 70% and 87%, respectively, while in patients with metastases, they were both 21%. Conclusion: In this unfavorable cohort of ESFT patients, radiation therapy was an effective modality for local control, especially for patients without metastases. The presence of metastases at diagnosis is a predictive factor not only for death but also for local failure. Future strategies for metastatic patients may include short course, high dose per fraction regimens. No significant financial relationships to disclose.
Preparation of resin filled ethylene vinyl alcohol copolymer hollow fiber membrane (2008)

Using ethylene vinyl alcohol copolymer(EVAL) as membrane matrix material,anion exchange resin D301R as functional particles,resin filled EVAL hollow fiber membrane are prepared by dry-wet spinning process.The effects of temperature of coagulation bath and concentration of EVAL on pure water flux and rejection of BSA are discussed.The experimental results show that the resin filled EVAL hollow fiber membrane is possessed of high water flux and BSA retention rate,when the concentration of EVAL,concentration of ion exchange resin in the casting solution and coagulation bath temperature are 18%,24% and 40-50 ℃ respectively.
Safeguarding Abila: Discovering evolving activist networks VAST 2014 mini challenge 1: Unstructured text and network data analysis (2014)

We introduce a system for visual analysis of news articles and emails. This system was developed in response to VAST Mini-Challenge 1 and comprises different interfaces for mining textual data and network data.
Comparing Energy Efficiency of CPU, GPU and FPGA Implementations for Vision Kernels (2019)

Developing high performance embedded vision applications requires balancing run-time performance with energy constraints. Given the mix of hardware accelerators that exist for embedded computer vision (e.g. multi-core CPUs, GPUs, and FPGAs), and their associated vendor optimized vision libraries, it becomes a challenge for developers to navigate this fragmented solution space. To aid with determining which embedded platform is most suitable for their application, we conduct a comprehensive benchmark of the run-time performance and energy efficiency of a wide range of vision kernels. We discuss rationales for why a given underlying hardware architecture innately performs well or poorly based on the characteristics of a range of vision kernel categories. Specifically, our study is performed for three commonly used HW accelerators for embedded vision applications: ARM57 CPU, Jetson TX2 GPU and ZCU102 FPGA, using their vendor optimized vision libraries: OpenCV, VisionWorks and xfOpenCV. Our results show that the GPU achieves an energy/frame reduction ratio of 1.1-3.2× compared to the others for simple kernels. While for more complicated kernels and complete vision pipelines, the FPGA outperforms the others with energy/frame reduction ratios of 1.2-22.3×. It is also observed that the FPGA performs increasingly better as a vision application's pipeline complexity grows.
Nanoengineered microcapsules for the fluorescent sensing of oxygen (2002)

Self-assembled microcapsules allow for the encapsulation of fluorescent dyes capable of the detection of many biochemicals. The stability and detection range of these sensors might make them optimal for use in microgravitational environments. A microencapsulated fluorescent oxygen sensor was. developed for the detection of O/sub 2/ in fluidic and cultured systems. This sensor provides real-time response for differing O/sub 2/ concentration in a useable range.
Viscose fabric bonded with soy protein isolate by foam application method (2013)

A soy protein-based water-soluble binder composition for natural fiber nonwoven fabric is discussed in this paper. Before applying to viscose fibers, foam decay studies of soy protein and acrylic binders are carried out and results are compared. The bio-binder (soy protein and sodium dodecyl sulphate modified soy protein) composition effectively binds natural fibers in a nonwoven fabric by foam application method. Such fabrics are widely used for industrial wipes and non-reusable products such as diapers, sanitary napkins, bandages, etc. The mechanical and thermal properties of viscose fabric bonded with soy protein bio-binder are compared with the same fabric produced with commercially applied acrylic binder. Scanning electron microscope was used to confirm the bonding of the viscose fiber with the bio-binders.
Drug product stability of aclidinium bromide in Genuair (2012)

Introduction: Aclidinium bromide is a novel, long-acting inhaled anticholinergic bronchodilator developed for the treatment of COPD. It is administered using a novel multidose dry powder inhaler called Genuair®, designed with an intuitive feedback system. The following studies were performed to evaluate the stability of the drug product (DP: Aclidinium bromide 400µg formulation & inhaler). Methods: The stability of commercial scale batches were tested (Appearance, identity, purity, content of active, delivered dose (DD), fine particle dose (FPD) and microbial purity) as follows: 1) Packed DP: ≤ 24 months storage in 2 orientations at different climatic conditions. 2) Opened DP: - In use: 12 months packed storage at different climatic conditions, then open storage, without the protective cap during the in use period. - Effect of moisture: 4 weeks open storage at 20°C/ 34%R.H. versus 25°C/ 75% R.H. 3) Stability under extreme stress conditions was tested: - Temperature cycling study: 2 weeks storage at -10°C to 40°C (alternating every 24 h). - Vibrational stability: stressed at 50 Hz, amp. 1 mm using 3 durations. 4) Photostability evaluated according to ICH conditions. Results: All tested samples and parameters confirmed the excellent stability of the packed and unpacked DP. Especially, the data for the pharmaceutical parameters DD (mean values: 362.4µg - 385.7µg) and FPD (mean values: 138.7µg - 164.3µg) were consistent and remained unchanged independent of storage time and conditions. Conclusion: The advanced design and technological features of the Genuair® combined with the Aclidinium bromide inhalation powder guarantee a stable and robust product under various climatic, mechanical, and light radiation stress conditions.
Concise Encyclopedia of Bioresource Technology (2004)

An easy-to-use reference source on the applications and management of biotechnology! The Concise Encyclopedia of Bioresource Technology is a unique resource for state-of-the-art research findings on biotechnological innovations and their potential for commercial exploitation. This comprehensive reference gives you immediate access to information on the application of bioresource technology as it relates to industrial, food, and environmental biotechnology. Practitioners, academics, and researchers representing a wide range of disciplines examine vital issues including the production and applications of microbial enzymes and organic acids, fermentation, wastewater treatment, and air pollution. The Concise Encyclopedia of Bioresource Technology will bring you up-to-date on advances in the applications and management of bioprocesses, biomass, bioenergy, biological waste treatment, biotransformations, and conversion and production technologies. This vital information has been organized in an easy-to-use format that lets you become familiar with highlights of the most relevant topics and includes photographs, figures, and tables. Issues addressed in the book include: agro-industrial residues for bioprocesses solid-state fermentation for bioconversion of biomass alcoholic fermentation food grade yeast production treatment of industrial effluents anaerobic animal waste environments reactors for wastewater treatment and much more! The Concise Encyclopedia of Bioresource Technology is a vital resource for practitioners, researchers, and academics working in the areas of biotechnology, chemical engineering, resource, energy and conservation sciences, process technology, applied microbiology, and farm and industrial waste technology.
Xen on ARM: System Virtualization Using Xen Hypervisor for ARM-Based Secure Mobile Phones (2008)

Mobile phones security is becoming an important issue because they are being connected to an Internet through wireless modem technologies. System virtualization technology provides trusted computing capability by running isolated multiple virtual machines under hypervisor. In this paper, we propose a design of system virtualization for ARM CPU architecture and describe implementation of prototype called Xen on ARM using Xen hypervisor. Secure and nonsecure guest Linux virtual machines are executing under Xen on ARM isolated with each other and virtualization overhead is shown to be moderate compared to native Linux running on bare metal H/W.
Improved energy and power balance at Nova targets (1990)

Cell and gene therapies (CGTs) are progressively entering into clinical practice in different parts of the world. The International Society for Cell & Gene Therapy (ISCT), a global scientific society, has been committed since 1992 to supporting and developing knowledge on clinical applications of CGTs. Considering the number of products that have been progressively approved and, in some cases, withdrawn in recent years, the ISCT would like to present a brief annual report on CGTs with marketing authorization (MA) in different regions. This article reflects the dynamic momentum around authorized CGTs coinciding with the parallel increase of unproven approaches where cells are delivered without appropriate and rigorous scientific and regulatory assessment and authorization. This is intended to be a living document with a yearly update linked to a dedicated section of the ISCT website for faster adjustments. The aim is to ultimately inform, by periodic snapshots, the scientific community, healthcare stakeholders and patient associations on authorized CGT products as a way to increase communication around the approved therapeutic approaches charged with heightened expectations.