gebhart/patrepeval huggingface dataset:
Complete amino acid sequence of guanaco (Lama guanicoe) cytochrome c (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplete amino acid sequence of guanaco (Lama guanicoe) cytochrome cR. L. Niece, E. Margoliash, and Walter M. FitchCite this: Biochemistry 1977, 16, 1, 68–72Publication Date (Print):January 11, 1977Publication History Published online1 May 2002Published inissue 11 January 1977https://pubs.acs.org/doi/10.1021/bi00620a011https://doi.org/10.1021/bi00620a011research-articleACS PublicationsRequest reuse permissionsArticle Views23Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differences in delineation of organs at risk lead to dose uncertainties during intensity-modulated radiotherapy for nasopharynx carcinoma (2014)

Objective To assess the differences in delineation of organs at risk (OAR) and dosimetry between junior and senior physicians during intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and to evaluate the role of specific training in reducing the differences.Methods Sixteen patients newly diagnosed with NPC were selected in the study.The OAR was delineated separately by three junior physicians and three senior physicians,and the geometric and dosimetric differences were assessed relative to the reference OAR.Delineation was performed again for the two OARs with the biggest difference after specific training in the two groups of physicians,and the differences were evaluated again.The difference was determined by paired t test.Results The maximum dose differences (Dmax) of OAR in the junior and senior physicians were (2.33 ± 12.06) ％ (-48.06％-137.82％) and (0.09 ± 4.72) ％ (-49.54％-42.96％),respectively (P =0.039),and the difference in the optic chiasm was the greatest ((5.85 ± 19.63) ％ ∶ (1.36 ± 4.64) ％,P =0.042).The mean dose differences (Dmean) of OAR in the junior and senior physicians were (3.10 ± 8.07)％ (-46.76％-59.76％) and (-0.93 ± 2.03) ％ (-45.54％-35.69％),respectively (P =0.021),and the difference in the parotid gland was the greatest ((13.23 ± 13.39) ％ ∶ (3.20 ± 6.71) ％,P =0.002).In the secondary delineation after training,the Dmax of the optic chiasm in the junior and senior physicians was (1.68 ± 3.34)％ and (1.50 ± 1.87) ％,respectively (P =0.841),and the difference in junior physicians was reduced significantly compared with before training ((1.68 ± 3.34) ％ ∶ (5.85 ± 19.63) ％,P =0.048) ; the Dmean of the parotid gland in the junior and senior physicians was (2.46 ± 3.06) ％ and (1.35 ± 3.00) ％,respectively (P =0.2 7 4),significantly reduced compared with before training ((2.46 ± 3.0 6) ％ ∶ (13.23 ± 13.39)％,P=0.002; (1.35 ± 3.00)％ ∶ (3.20 ± 6.71) ％,P =0.033).Conclusions The differences in delineation of OAR lead to dose uncertainties during IMRT for NPC,and specific training can improve the accuracy of delineation.

Key words: 
Organs at risk delineation;  Dosimetry;  Nasopharynx neoplasms/intensity modulated radiotherapy
DNAMAT: an efficient graphic matrix sequence homology algorithm and its application to structural analysis (1986)

We present a fast algorithm to produce a graphic matrix representation of sequence homology. The algorithm is based on lexicographical ordering of fragments. It preserves most of the options of a simple naive algorithm with a significant increase in speed. This algorithm was the bais for a program, called DNAMAT, that has been extensively tested during the last three years at the Weizmann Institute of Science and has proven to be very useful. In addition we suggest a way to extend our approach to analyse a series of related DNA or RNA sequences, in order to determine certain common structural features. The analysis is done by 'summing' a set of dot-matrices to produce an overall matrix that displays structural elements common to most of the sequences. We give an example of this procedure by analysing tRNA sequences.
Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists (2016)

We describe the synthesis of a novel class of brain penetrating P2X7 antagonists with high potency at both the rat and human P2X7 receptors. Disclosed herein are druglike molecules with demonstrated target engagement of the rat P2X7 receptors after an oral dose. Specifically, compound 20 occupied the P2X7 receptors >80% over the 6 h time course as measured by an ex vivo radioligand binding experiment. In a dose-response assay, this molecule has a plasma EC50 of 8 ng/mL. Overall, 20 has suitable druglike properties and pharmacokinetics in rat and dog. This molecule and others disclosed herein will serve as additional tools to elucidate the role of the P2X7 receptor in neuropsychiatric disorders.
Simple Correlations between Rock Abrasion and Other Significant Rock Properties for Rock Mass and Intact Quartzite (2017)

Rock abrasion plays a significant role in geotechnical design, tunneling operations and the safety of foundations from scour. It is imperative to determine such properties of uniaxial compression strength (UCS), rock quality designation (RQD) and hardness for rock engineering to help determine the amount of scour at foundation locations in order to prevent structural collapse, wear on drilling tools and help predict unstable rock conditions. Current practice for estimating maximum rock abrasion is based on the Los Angeles abrasion test; however, more research is needed to provide a more accurate and compatible method for all subsurface materials used in mining and civil engineering projects. This report will provide simple correlations relating abrasion resistance to RQD, UCS, Geological Strength Index (GSI) and Rock Mass Rating (RMR) and shear strength of metamorphic rock (Quartzite). Methods, results, recommendations and conclusions are presented. The paper also introduces recommendations for future rock abrasion techniques and discusses the use of these correlations exhibiting strong relationships between the mentioned rock properties.
Wireless Biometric Individual Identification Utilizing Millimeter Waves (2017)

Biometrics offer a personal and convenient way of keeping our identities and our data secure. Here, we introduce a method of using mm-wave sensors to identify various individuals. In our system prototype, the compact radar sensor has two transmit antennas and four receive ones. The transmitter(s) send a sequence of signals which are reflected and scattered from a nearby part of the body of a user (a hand in our demo case). Different signal processing algorithms are applied to the received signals in order to create a rich feature dataset. In our demo system, the resulting dataset is classified using a random forest machine learning model, which is shown to facilitate identifying a group of individuals with high accuracy. This technology has promising implications in terms of using mm-wave radars as an independent or an auxiliary tool for biometric authentication.
Taller staff occupationally exposed to less radiation to the temple in cardiac procedures, but risk higher doses during vascular cases (2020)

This study aimed to evaluate the effect of nurse and doctor height on occupational dose to the temple during fluoroscopically guided cardiovascular procedures. Additionally, an evaluation of the relationship between doctor height and table height was performed. Staff exposed during fluoroscopic procedures may be at elevated risk of cardiovascular damage or oncogenesis and have demonstrated a higher incidence of subscapular cataracts. The heads of taller staff may be exposed to reduced levels of radiation due to the increased distance from the area of highest intensity X-ray scatter. Limited research has been performed investigating height as a predictor of head dose to nursing staff. The level of radiation dose at the level of the temple to the doctor (n = 25), scrub (n = 28), and scout nurse (n = 29) was measured in a prospective single-center, observational study using Philips DoseAware badges. Procedural characteristics were recorded for vascular and cardiac cases performed in three dedicated angiography suites. Data were also collected to investigate relationships between doctor height and table height. Data were collected for 1585 cardiac and 294 vascular procedures. Staff height was a statistically significant predictor of temple dose for doctors, scrub, and scout nurses when considering the full data sample. The log temple dose demonstrated an inverse relationship to staff height during cardiac procedures, but a positive relationship for scrub and scout nurses during vascular studies. This observational study has demonstrated that taller staff are exposed to less cranial exposure dose during fluoroscopically guided cardiac examinations but has revealed a positive correlation between height and temple dose during vascular procedures. It was also determined that doctor height was correlated with average procedural table height and that vascular access point influences the choice of table elevation.
Saturation of the ionospheric polar cap potential during the October–November 2003 superstorms (2005)

The question of whether the cross polar cap potential drop in the Earth's ionosphere saturates under conditions of extreme electric field in the solar wind has been tested observationally during the past several years. The challenge to proving the existence of this phenomenon is that periods of such extreme electric fields in the solar wind are relatively rare. The three superstorms of October and November 2003 provided ideal cases for testing this idea. We first review the earlier evidence of the saturation seen by the DMSP‐F13 spacecraft during the 31 March 2001 superstorm and other storm events during the 1998–2002 time period. Then we present observations from the DMSP‐F13 spacecraft during the October and November 2003 superstorms that show definite evidence of this saturation. In addition, some of the electric fields during these superstorms were almost twice as large as the largest fields previously studied, thus increasing the range of our sample set and further increasing our confidence in the existence of the saturation phenomenon. The data are compared with the saturated potentials predicted by the Hill‐Siscoe model to test its validity. The DMSP measurements indicate that the saturation limit of the cross polar cap is about 260 kV.
OPERATING MODEL OF KNOWLEDGE QUANTUM ENGINEERING FOR DECISION-MAKING IN CONDITIONS OF INDETERMINACY (2007)

Abstract: The operating model of knowledge quantum engineering for identification and prognostic decisionmaking in conditions of α-indeterminacy is suggested in the article. The synthesized operating model solves three basic tasks: Аt-task to formalize tk-knowledge; Вt-task to recognize (identify) objects according to observed results; Сt-task to extrapolate (prognosticate) the observed results. Operating derivation of identification and prognostic decisions using authentic different-level algorithmic knowledge quantum (using tRAKZ-method) assumes synthesis of authentic knowledge quantum database (BtkZ) using induction operator as a system of implicative laws, and then using deduction operator according to the observed tk-knowledge and BtkZ a derivation of identification or prognostic decisions in a form of new tk-knowledge.
Biological Variation in Tests of Hemostasis (2009)

The two components of biological variability are interindividual variability, which is the variability due to the heterogeneity of physiologic influences among subjects, and intraindividual variability, which is due to the variability in the same individual over time. Analysis of biological variation is crucial for estimating the critical difference, which corresponds with a threshold suggestive of a statistically significant difference between two consecutive results of a laboratory parameter in the same subject and is therefore unlikely attributable to casual (random) oscillation of values. Studies on biological variation of tests of hemostasis are outdated, and the published results should be confirmed by using modern, fully automated methods. Biological variation for coagulation screening tests (prothrombin time and activated partial thromboplastin time) is low and comparable with the values registered for hematologic parameters. However, the index of individuality (ratio between intraindividual and interindividual variability) suggests that the usual preoperative screening for coagulation disorders is influenced by the between-subjects variability. Thrombin time is very constant within and between subjects. Proteins such as fibrinogen, clotting factors, and antithrombin show a low biological variability. In contrast, fibrinolytic parameters, such as plasminogen activator inhibitor 1 and fibrinopeptide A, show very high variability, and their interpretation in the clinical setting must take this into consideration.
Effect of CYP2C19 Polymorphism on Treatment Success in Lansoprazole-Based 7-Day Treatment Regimen for Cure of H. pylori Infection in Japan (2008)

Recently, Helicobacter pylori (H. pylori)-positive peptic ulcer patients were treated by a 1-week triple therapy [lansoprazole (LPZ) 30 mg, amoxicillin 750 mg and clarithromycin 200 or 400 mg, each twice daily] without the checking CYP2C19 genotype in Japan. This regimen was done to obtain sufficient cure rates for H. pylori infection using a high dose of LPZ (60 mg/day) without the great cost of having to determine the genotype. However, the failure rate for eradicating H. pylori was reported to be 12.5%. The reasons for this were studied in 33 Japanese patients with H. pylori-positive gastric or duodenal ulcer. Blood samples of the patients were collected to determine the genotype of CYP2C19 and plasma concentrations of LPZ and its metabolites at 3 h postdose on the morning of the 7th day of treatment. H. pylori infection was cured in 25 of the 33 patients (75.8%). The cure rate was highest in the group of poor metabolizers (PM), intermediate in the group of extensive metabolizers of the heterozygous type (htEM) and lowest in the group of extensive metabolizers of the homozygous type (hmEM). The relative ratio of mean plasma concentration for LPZ among the 3 groups was 1.00:1.43:2.93 (hmEM:htEM:PM groups). Our data suggest that success of the eradication is dependent on the CYP2C19-related genotypic status or the plasma concentrations of LPZ in a steady state condition after a multiple dosing regimen; that is to say, checking CYP2C19 is necessary even on occasions when treatment is done by H. pylori eradication methods as performed in Japan.
Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative Study (2023)

FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH Mobetron system. The two centers used similar beam parameters but otherwise conducted the studies independently. The FLASH-enabled animal survival and intestinal crypt regeneration after irradiation were comparable between the two centers. These findings, together with previously published data using a converted linear accelerator, show that a robust and reproducible FLASH effect can be induced as long as the same set of irradiation parameters are used.
Emerging Therapies in Friedreich’s Ataxia (2016)

Friedreich's ataxia (FRDA) is an inherited, progressive neurodegenerative disease that typically affects teenagers and young adults. Therapeutic strategies and disease insight have expanded rapidly over recent years, leading to hope for the FRDA population. There is currently no US FDA-approved treatment for FRDA, but advances in research of its pathogenesis have led to clinical trials of potential treatments. This article reviews emerging therapies and discusses future perspectives, including the need for more precise measures for detecting changes in neurologic symptoms as well as a disease-modifying agent.
Prospects for point-of-care pathogen diagnostics using surface-enhanced Raman scattering (SERS) (2016)

Surface-enhanced Raman scattering (SERS) has enabled the detection of pathogens and disease markers at extremely low levels. This review examines the potential impact of SERS in addressing unmet needs in pathogen diagnostics both in a traditional clinical setting and in the point of care (POC) arena. It begins by describing the strengths and weaknesses of today's diagnostics technologies in order to set a contextual stage for an overview which highlights a few of the many recent developments using SERS in biodefense, human and animal health, and monitoring food and water safety. These sections are followed by discussions of the challenges for the translation of these developments to POC settings, including the performance attributes and metrics for quantification of analytical and clinical figures of merit (e.g., limit of detection and clinical accuracy), and the pathways for large-scale test validation and the build-out of instrumentation and tests kits for POC deployment.
Cell-Based Electrochemical Assay for Endotoxin Using a Secreted Alkaline Phosphatase Reporter System (2008)

We developed a cell-based assay device for the detection of endotoxin, the potentially toxic compound that induces septic shock. Genetically-engineered cells that secrete alkaline phosphatase (SEAP) on exposure to endotoxin were cultured in an electrochemical cell device in medium containing p-aminophenyl phosphate and various concentrations of endotoxin. After 24 hr incubation, p-aminophenol (pAP), generated by SEAP-catalyzed hydrolysis, was detected by amperometry at +0.35 V. The amperometric response increased with the concentration of endotoxin in the range of 0.01–1 ng/ml.
Immunochemical Comparison of Glutamine Synthetases from Some Solanaceae Plants (1986)

The presence of different glutamine synthetase isoenzymes in different Solanaceae plants and their relative antigenicities against antiglutamine synthetase from tomato leaf serum were studied. All the plants tested showed one glutamine synthetase isoenzyme except for Mandragora autumnalis, which showed two, after discontinuous polyacrylamide gel electrophoresis and specific in situ assay. Antigenicities were compared by the double immunodiffusion technique. The Nicotiana glauca enzyme showed equal reactivity to that of Lycopersicon esculentum, but its antigenicity was higher than Withania frutescens, Datura stramonium, and Hyoscyamus niger. The study of relative antigenicities permitted differentiation of the glutamine synthetase enzymes from uncultivated species of Solanaceae.
Development of a calculator for Edge and Parallel Coupled Microstrip band pass filters (2014)

This paper presents an implemented calculator tool for the design of Edge/ Parallel Coupled Microstrip Band Pass Filters (PCMBPF) that makes use of the MATLAB software. This calculator allows estimating both the parameters required for the design of the PCMBPF and the electrical response which is obtained by means of the equivalent circuit of this type of filters. Based on the transmission line theory approach (TLTA), the calculator herein proposed is a good solution to simply obtain the design parameters of this type of filters given that all formulas required for the PCMBPF design are programmed using close-form mathematic expressions and the coupling matrix concept. In order to validate our calculator performance, we implemented the proposed filter in a commercial electromagnetic simulator CST MWs that considers a set of electromagnetic effects, and accurately determine the final filter design. Secondly, we compared these simulation outcomes with the measurement results, achieving a reasonable agreement.
Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer (2011)

Here, we have shown that PLX4720 preferentially inhibits migration and invasion of B-Raf(V600E) thyroid cancer cells and tumor aggressiveness. Normal thyroid cells were generated to be heterozygous for wild-type B-Raf/B-Raf(V600E), mimicking the condition found in most human thyroid cancers. PLX4720 was effective in reducing cell proliferation, migration, and invasion in this heterozygous model. PLX4720 therapy should be tested and considered for a phase I study for the treatment of patients with B-Raf(V600E) ATC.
Synchronization state buffer (2007)

Efficient fine-grain synchronization is extremely important to effectively harness the computational power of many-core architectures. However, designing and implementing finegrain synchronization in such architectures presents several challenges, including issues of synchronization induced overhead, storage cost, scalability, and the level of granularity to which synchronization is applicable. This paper proposes the Synchronization State Buffer (SSB), a scalable architectural design for fine-grain synchronization that efficiently performs synchronizations between concurrent threads. The design of SSB is motivated by the following observation: at any instance during the parallel execution only a small fraction of memory locations are actively participating in synchronization. Based on this observation we present a fine-grain synchronization design that records and manages the states of frequently synchronized data using modest hardware support. We have implemented the SSB design in the context of the 160-core IBM Cyclops-64 architecture. Using detailed simulation, we present our experience for a set of benchmarks with different workload characteristics.
T-RAID: TEE-based Remote Attestation for IoT Devices (2022)

Abstract The Internet of Things (IoT) consists of network-connected embedded devices that enable a multitude of new applications, but also create new risks. In particular, embedded IoT devices can be infected by malware. Operators of IoT systems not only need malware detection tools, but also scalable methods to reliably and remotely verify malware freedom of their IoT devices. In this paper, we address this problem by proposing T-RAID, a remote attestation scheme for IoT devices that takes advantage of the security guarantees provided by a Trusted Execution Environment running on each device.
Pre‐gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity (2008)

Pre-gravid vigorous/sports activity is associated with a reduced risk of glucose intolerance in pregnancy, an effect likely mediated by enhanced insulin sensitivity.