gebhart/patrepeval huggingface dataset:
Waste Tank Vapor Program: Vapor space characterization of Waste Tank 241-T-107. Results from samples collected on January 18, 1995 (1995)

This report describes inorganic and organic analyses results from samples obtained from the headspace of the Hanford waste storage Tank 241-T-107 (referred to as Tank T-107). The results described here were obtained to support safety and toxicological evaluations. A summary of the results for inorganic and organic analytes is listed in Table 1. Detailed descriptions of the results appear in the text. Quantitative results were obtained for the inorganic compounds ammonia (NH{sub 3}), nitrogen dioxide (NO{sub 2}), nitric oxide (NO), and water (H{sub 2}O). Sampling for hydrogen cyanide (HCN) and sulfur oxides (SO{sub x}) was not requested. In addition, quantitative results were obtained for the 39 TO-14 compounds plus an additional 14 analytes. Of these, I was observed above the 5-ppbv reporting cutoff. Six organic tentatively identified compounds (TICs) were observed above the reporting cutoff of (ca.) 10 ppbv and are reported with concentrations that are semiquantitative estimates based on internal-standard response factors. The estimated concentration of all 7 organic analytes observed in the tank headspace are listed in Table I and account for approximately 100% of the total organic components in Tank T-107. Two permanent gases, carbon dioxide (CO{sub 2}) and nitrous oxide (N{sub 2}O), were also detected in the tank-headspace samples.
Pathogenic Mitochondrial DNA Mutations Are Common in the General Population (2008)

Mitochondrial DNA (mtDNA) mutations are a major cause of genetic disease, but their prevalence in the general population is not known. We determined the frequency of ten mitochondrial point mutations in 3168 neonatal-cord-blood samples from sequential live births, analyzing matched maternal-blood samples to estimate the de novo mutation rate. mtDNA mutations were detected in 15 offspring (0.54%, 95% CI = 0.30-0.89%). Of these live births, 0.00107% (95% CI = 0.00087-0.0127) harbored a mutation not detected in the mother's blood, providing an estimate of the de novo mutation rate. The most common mutation was m.3243A-->G. m.14484T-->C was only found on sub-branches of mtDNA haplogroup J. In conclusion, at least one in 200 healthy humans harbors a pathogenic mtDNA mutation that potentially causes disease in the offspring of female carriers. The exclusive detection of m.14484T-->C on haplogroup J implicates the background mtDNA haplotype in mutagenesis. These findings emphasize the importance of developing new approaches to prevent transmission.
Novel and recurrent mutations in keratinKRT5andKRT14genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly (2006)

Epidermolysis bullosa simplex (EBS) is a group of autosomal dominant genetic skin disorders caused by mutations of the keratin genes KRT5 and KRT14. It is characterised by lysis of basal keratinocytes leading to the development of intraepidermal blisters upon minor mechanical trauma. We investigated 27 EBS patients and families of mainly German origin by sequence analysis of the entire coding sequences of KRT5 and KRT14 and identified 12 novel and seven previously reported mutations within the KRT5 and KRT14 genes. The study discusses possible implications of the novel mutations on protein structure, keratin intermediate filament (KIF) formation and the corresponding phenotype, and summarises the spectrum of mutations reported so far in EBS. Detailed knowledge of the spectrum of EBS mutations and their genotype-phenotype correlation is essential for accurate genetic counselling and prenatal diagnosis.
Compositon of the essential oil of rhizomes of kaempferia galanga L. (1992)

Abstract The compositon of the essential oil of rhizomes of Kaempferia galanga L. growing in Malaysia has been investigated by capillary GC, GC‐MS and 1 H‐NMR. The oil contained 54 components, of which the major constituents were ethyl trans ‐p‐methoxycinnamate (51.6%), ethyl cinnamate (16.5%), pentadecane (9.0%), 1,8‐cineole (5.7%), γ‐car‐3‐ene (3.3%) and borneol (2.7%). Terpenoid constituents amounted to 16.4%.
Flexible, Lightweight Sensor for Monitoring Wiring in Aircraft (2006)

In this paper, we have presented results for a flexible, lightweight, high bandwidth sensor for passive monitoring of the health of aircraft wiring. The sensor acquires discharge signals from aircraft wiring for identification of potential insulation failure. On-going work is aimed at improving the transfer function of the sensor and demonstrating in an aircraft wiring system
Early Environment and Neurobehavioral Development Predict Adult Temperament Clusters (2012)

Background&#13;\n&#13;\nInvestigation of the environmental influences on human behavioral phenotypes is important for our understanding of the causation of psychiatric disorders. However, there are complexities associated with the assessment of environmental influences on behavior.&#13;\nMethods/Principal Findings&#13;\n&#13;\nWe conducted a series of analyses using a prospective, longitudinal study of a nationally representative birth cohort from Finland (the Northern Finland 1966 Birth Cohort). Participants included a total of 3,761 male and female cohort members who were living in Finland at the age of 16 years and who had complete temperament scores. Our initial analyses (Wessman et al., in press) provide evidence in support of four stable and robust temperament clusters. Using these temperament clusters, as well as independent temperament dimensions for comparison, we conducted a data-driven analysis to assess the influence of a broad set of life course measures, assessed pre-natally, in infancy, and during adolescence, on adult temperament.&#13;\nResults&#13;\n&#13;\nMeasures of early environment, neurobehavioral development, and adolescent behavior significantly predict adult temperament, classified by both cluster membership and temperament dimensions. Specifically, our results suggest that a relatively consistent set of life course measures are associated with adult temperament profiles, including maternal education, characteristics of the family’s location and residence, adolescent academic performance, and adolescent smoking.&#13;\nConclusions&#13;\n&#13;\nOur finding that a consistent set of life course measures predict temperament clusters indicate that these clusters represent distinct developmental temperament trajectories and that information about a subset of life course measures has implications for adult health outcomes.
Late-Onset Alzheimer's Disease, Heating up and Foxed by Several Proteins: Pathomolecular Effects of the Aging Process (2014)

Late-onset Alzheimer's disease (LOAD) is the most common neurodegenerative disorder in older adults, affecting over 50% of those over age 85. Aging is the most important risk factor for the development of LOAD. Aging is associated with the decrease in the ability of cells to cope with cellular stress, especially protein aggregation. Here we describe how the process of aging affects pathways that control the processing and degradation of abnormal proteins including amyloid-β (Aβ). Genetic association studies in LOAD have successfully identified a large number of genetic variants involved in the development of the disease. However, there is a gap in understanding the interconnections between these pathomolecular events that prevent us from discovering therapeutic targets. We propose novel, pertinent links to elucidate how the biology of aging affects the sequence of events in the development of LOAD. Furthermore we analyze and synthesize the molecular-pathologic-clinical correlations of the aging process, involving the HSF1 and FOXO family pathways, Aβ metabolic pathway, and the different clinical stages of LOAD. Our new model postulates that the aging process would precede Aβ accumulation, and attenuation of HSF1 is an "upstream" event in the cascade that results in excess Aβ and synaptic dysfunction, which may lead to cognitive impairment and/or trigger "downstream" neurodegeneration and synaptic loss. Specific host factors, such as the activity of FOXO family pathways, would mediate the response to Aβ toxicity and the pace of progression toward the clinical manifestations of AD.
Degradation surveillance module for optical transport networks (2002)

We propose a system offering a common-equipment to detect several types of degradations helping a cost-effective and pro-active maintenance strategy in optical fibre networks. The principle of the described system is to sound both the power and frequency quality of the optical signals in a per link and per band basis.
Studies on the microflora, aflatoxin, and p-aminobenzoic acid content of peanut fruits from Mexico and the influence of selected gases on aflatoxin production in peanuts by Aspergillus flavus link (1969)

Sound, Mature peanut kernels grown in Mexico were examined for aflatoxin contamination previous to the normal harvest data and following storage. Peanut kernels were free of aflatoxins before harvesting but traces to high levels were found in stored peanuts. Fusarium spp. were more prevalent in kernels at harvest; however, following storage, fungi of the Aspergillus glaucus group were more commonly isolated. The efficacy was tested of Polyram, EL 305, PCNB, and Difolatan in controlling actively growing mycelium of Fusarium oxysporum, Rhizoctonia solani, and Sclerotium rolfsii. Results indicated that Difolatan had fungicidal effects against Fusarium oxysporum while EL 305 was most active against R. solani and S. rolfsii. Peanuts at kernel moisture contents of 48.9, 38.3, 36.9, 32.8, 25.4, 12.8, and 5.7 percent were inoculated with A. flavius and incubated under compressed air, 2-aminobutane, nitrogen, and a mixture of 87% CO₂, 13% N₂ for 9 days at 25 C. Compressed air and the mixed gas (87% CO₂, 13% N₂) allowed aflatoxin production in kernels with moisture contents of 32.8 and 25.4 percent. Peanut kernels stored under N₂ atmosphere developed an offensive odor. Peanut kernels stored under a 2-aminobutane atmosphere or washed with a liquid solution of the compound absorbed large quantities of the chemical. The p-aminobenzoic acid content of 15 peanut varieties grown in Mexico was determined by diazotizing and coupling an aqueous filtrate. The content of p-aminobenzoic acid was 15 ug for the variety Deschecho PNS and six other varieties contained more than 3.5 ug/g. The remaining 8 varieties contained p-aminobenzoic acid contents ranging from 0.5 to 3.0 ug/g.
The Internal Bony Architecture of the Sacrum (1998)

The internal bony architecture of the sacrum has several consistent features. The relatively uniform cortical thickness seen in each sacral specimen may have clinical significance in the internal fixation of this region.
Long Chain Branching Detection and Quantification in LDPE with Special Solvents, Polarization Transfer Techniques, and Inverse Gated 13C NMR Spectroscopy (2018)

Recent global demand of polyethylene was 187 billion pounds with 23% being low density polyethylene (LDPE). LDPE is used in a variety of applications including liners, consumer bags, heavy duty sacks, caps, closures, toys, lamination, and agricultural films. A key feature of LDPE is the presence of long chain branching (LCB) which has a significant impact on physical and rheological properties, including melt strength. Previously it was reported that there are no C6 branches in LDPE, and therefore the common practice has been to use the resonance around 32.2 ppm as a measure of LCB content. Herein, the existence of C6 branches in LDPE is reported for the first time, enabled by the use of 1-chloronaphthalene as the NMR solvent. It is shown that the C6 branches have a contribution to the resonance around 32.2 ppm. This finding suggests that C6 branches should be measured in LDPE samples and be excluded from LCB quantification because they do not affect LDPE rheological properties as LCB does. The data obtained strongly suggest that C7 branches are present in much lower concentrations in the LDPE samples studied. The quantification of these resonances traditionally requires long acquisition time, even with the use of a cryoprobe. In this work, different polarization transfer techniques, refocused insensitive nuclei enhanced by polarization transfer (RINEPT), and distortionless enhancement by polarization transfer (DEPT) were compared in terms of their ability to enhance CH2 sensitivity, thus leading to a greater ability to observe the CH2 resonances belonging to the C6 branches. It was found that RINEPT with hard 180° 13C pulses is most suitable for this purpose. A much faster method is proposed for measuring LCB in LDPE that employs a combination of a conventional quantitative 13C NMR technique and a polarization transfer technique.
Interaction between cholinergic neurons and substance P or calcitonin gene‐related peptide terminals of the rat sacral intermediolateral nucleus: Double immunostaining at the light and electron microscopic levels (1989)

The relationships both between cholinergic neurons and substance P (SP) and between cholinergic neurons and calcitonin gene-related peptide (CGRP) terminals were examined in the rat sacral intermediolateral nucleus at the light and electron microscopic levels by means of double-immunostaining methods. Cholinergic neurons were labeled by a monoclonal antibody to choline acetyltransferase (CAT) with the avidin-biotin technique and stained bluish-green by indolyl-beta-galactoside reaction products with beta-galactosidase as a marker. On the same sections, SP or CGRP fibers were labeled by polyclonal antisera to SP or CGRP after application of the peroxidase-antiperoxidase (PAP) method and stained brown by the p-dimethylaminoazobenzene (DAB) reaction. After embedding in Epon, light and electron microscopic sections were examined. At the light microscopic level, CGRP-like immunoreactive (CGRP-I) fibers and SP-like immunoreactive (SP-I) fibers were found to pass through the lateral edge of the dorsal horn and then into the dorsal region of the sacral intermediolateral nucleus. In addition, SP-I fibers also extend from the dorsolateral funiculus into the entire sacral intermediolateral region. At the electron microscopic level, many axosomatic and axodendritic synapses were found between CAT-I structures and SP-I terminals in the intermediolateral nucleus, whereas most of the CGRP-I terminals in this area made axodendritic synapses with CAT-I dendrites. These results indicate that cholinergic neurons in the sacral intermediolateral nucleus receive direct synaptic input from SP-I and CGRP-I terminals.(ABSTRACT TRUNCATED AT 250 WORDS)
Complete Genome Sequence of Rhodococcus sp. Strain WMMA185, a Marine Sponge-Associated Bacterium (2016)

The Rhodococcus strain WMMA185 was isolated from the marine sponge Chondrilla nucula as part of ongoing drug discovery efforts. Analysis of the 4.44-Mb genome provides information regarding interspecies interactions as pertains to regulation of secondary metabolism and natural product biosynthetic potentials.
Real-Time Monitoring of Thermal Response and Life-Time Varying Parameters in Power Modules (2020)

This article introduces new technologies for monitoring thermal response and life-time varying parameters of power electronic modules in real time without interrupting normal converter operation. The technologies are embedded in an adaptive thermal observer, which integrates temperature measurements and electrothermal models to estimate device losses and temperatures at reliability-critical locations of the power module. The observer structure includes a model reference adaptive system for adaptively calibrating device switching-loss models. This improves thermal monitoring accuracy, avoids time-consuming offline calibrations, and creates the opportunity for efficiency estimations during power module operation. The adaptive observer together with small-signal loss-excitation and system-identification technologies extract the thermal impedance of the power module in magnitude and phase over multiple frequency decades. This <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in situ</i> thermal impedance spectroscopy has the unique feature of continuously providing information on the thermal interface of the power devices without interrupting normal inverter operation. The extracted information, i.e., life-time varying electrical and thermal parameters, enables diagnosing power module state-of-health with improved accuracy compared to prior technologies. It even allows separating different degradation effects, such as bond wire lift-off, device and base-plate solder delamination as well as deterioration of the convection process. With these new features, next generation monitoring systems can extract thermal response and degradation and thus protect power modules from severe thermal stress and overload. Furthermore, the obtained state-of-health information can be selectively used to reduce thermal stress and to schedule predictive maintenance leading to a safer and more reliable operation of future converter systems.
Killing Effect of the Replicative Oncolytic Adenovirus SG511-pHSP70-IL24 on Hepatoma Cell in Vitro (2011)

The experiment is aimed at studying the anti-tumor effect of SG511-pHSP70-IL24 in hepatoma cells.First,ELISA experiment shows that IL-24 is expressed in Hep3B and SMMC-7721.Second,MTT assay is used to test the growth inhibition effects of single or combination therapy on tumor cell lines SMMC-7721,Hep3B and human normal cell line BJ and MRC-5.Cytopathic effect assay then is conducted to further demonstrate the efficacy of the combination therapy.Results show that the anti-tumor efficacy of SG511-pHSP70-IL24 has greater toxicity in killing Hep3B and SMMC-7721,showing no toxicity against normal cell line BJ and MRC-5.
Continuous Lyman-alpha generation by four-wave mixing in mercury for laser cooling of antihydrogenThis paper was presented at the International Conference on Precision Physics of Simple Atomic Systems, held at École de Physique, les Houches, France, 30 May – 4 June, 2010. (2011)

Cooling antihydrogen atoms is important for future experiments both to test the fundamental CPT symmetry by high resolution laser spectroscopy and also to measure the gravitational acceleration of antimatter. Laser cooling of antihydrogen can be done on the strong 1S–2P transition at the wavelength of Lyman-alpha (121.6 nm). A continuous wave laser at the Lyman-alpha wavelength based on solid-state fundamental lasers is described. By using a two-photon and a near one-photon resonance a scan across the whole phase matching curve of the four-wave mixing process is possible. Furthermore the influence of the beam profile of one fundamental beam on the four-wave mixing process is studied.
A Non - Dissipative Mechanism of Acoustic Radiation Force Generation (2006)

A general approach to the description of radiation force (RF) and shear displacement induced by an ultrasonic beam in a nonlinear rubber‐like medium is developed. A new, non‐dissipative mechanism of RF generation due to medium inhomogeneity is suggested, and the corresponding medium response is calculated for rubber‐like media such as biological tissues.
Rapid immunofluorescent determination of cells in the S phase in pea root meristems: An alternative to autoradiography (1987)

Root meristems of Pisum sativum L. cv. Lincoln were pulsed with bromodeoxyuridine, and after partial DNA denaturation the incorporated precursor was detected with an indirect immunofluorescent method by means of commercial anti‐bromodeoxyuridine monoclonal antibody and fluorescein isothiocyanate‐labeled secondary antibody. The nuclei were counterstained with the DNA‐specific fluorochrome 4′, 6‐diamidino‐2‐phenylindole (DAPI). The labeling indices (percentage of labeled calls) determined on slides prepared with the same nuclear population were very similar and in strict accordance with autoradiographic data. When DAPI fluorescence of the nuclei was measured, the unlabeled nuclei coincided with the G1 and part of the G2 regions, whereas all the labeled nuclei were in the S or G2 region. The method is reliable and, in contrast to autoradiography, data can be collected rapidly and almost immediately after the pulse. Furthermore, labeling index and the distribution of DNA contents can be obtained from the same side.
Hypoglycemia-induced effects on cell proliferation, cell death, and glucose metabolism in organogenesis-stage embryonic mouse heart. (2005)

Hypoglycemia is a common clinical condition and is believed to cause cardiac malformations in offspring born to diabetic mothers. This study investigates the in vivo and in vitro effects of hypoglycemia on glucose metabolism, cell death and cell proliferation in the organogenesis-stage embryonic mouse heart. This study also offers a possible way to prevent excessive cell death due to hypoglycemia by over expressing Hsp70. Effects on glucose metabolism were evaluated by 13C-NMR spectroscopy to study glucose utilization and lactate production in embryonic day (E) 10.5 embryonic hearts exposed to hypoglycemia (40 mg/dl glucose) compared to normoglycemia (150 mg/dl glucose). Cell death was evaluated by TUNEL, Lysotracker&amp;#174;, active caspase-3 protein expression in vivo and in vitro, and by flow cytometry using TUNEL and myosin heavy chain in vivo. Cell proliferation was evaluated by p53, and PCNA immunohistochemistry and Western analysis. Hsp70 over-expression was achieved in isolated heart cultures and the hearts post-culture were stained with Lysotracker&amp;#174; or used for Western analysis to analyze Hsp70 over-expression and active caspase-3 expression. 13C-NMR spectroscopy revealed increased lactate production in hearts exposed to hypoglycemia as compared to normoglycemia indicative of increased glucose metabolism by glycolysis. TUNEL, Lysotracker&amp;#174;, and active caspase-3 assays indicate increased cell death induced by hypoglycemia in E9.5 and E10.5 embryonic hearts but not in E8.5 embryonic hearts. Flow cytometry results are similar to TUNEL and Lyostracker&amp;#174; results. p53 and PCNA analysis demonstrates decreased cell proliferation in response to hypoglycemia during organogenesis. Over-expressing Hsp70 helped prevent excessive cell death induced by hypoglycemia in embryonic mouse hearts. Over-expressing Hsp70 significantly reduced active capase-3 expression as demonstrated by Western analysis. The results indicate that 24 hr hypoglycemic exposure in vivo and in vitro significantly alters glucose metabolism, cell death and cell proliferation in the organogenesis-stage embryonic mouse heart. These effects may eventually contribute to lethality in the embryo or congenital cardiac defects observed in diabetic offspring.
Two Dimensional Scanning LIDAR for Planetary Explorer (2006)

The two-dimensional scanning LIDAR system which used MEMS technology is proposed. The specification of LIDAR under development are measurable range of 50m–50km, ±5 degrees of scanning angles, 10Hz repetition rate, and ±1m in range finding accuracy. By adopting monolithic YAG laser as a laser source, the tolerance over machine vibration has been improved with volume and weight saving. For a transmitting laser scan, adoption of a magnetic resonance drive type single micro-mirror is considered. In this system, we propose a novel method on the beam scanning mechanism for a receiver telescope with big aperture by using MEMS technology. The scanning optics system of receiver telescope is composed by a telecentric telescope and a micro shutter array. This optical system has achieved a narrow viewing angle corresponding to aperture of the shutter by limiting the view of the telescope that has a wide viewing angle with the shutter. The basic function of the scanning system of receiver optics is already checked experimentally.