gebhart/patrepeval huggingface dataset:
The challenge with teach-back: learning from negative results from the health literacy in pharmacy (HeLP) RCT in Australia (2016)

Introduction: Limited health literacy (HL) is highly prevalent in Australia With a consensus that services must adapt to meet patient needs. A dearth of interventions in pharmacy needs to be addressed.

Methodology: The HeLP educational programme for pharmacy staff was developed to enhance services and reduce the impact of medicines misadventure, evaluated by a cluster-randomised controlled trial, conducted in 77 pharmacies. HeLP was designed and delivered over 9 111onths by a consortium of 6 universities, Which introduced HL concepts and effects and then strategics to minimise risk. A core HL strategy is using 'teach-back' during counselling to determine and reinforce patient understanding. This, with other behavioural strategies, was assessed by observation, self-report, patient interviews (pre /post intervention) and focus groups with pharmacy staff.

Results: Use of teach-back decreased significantly after the intervention. Focus groups described greater awareness of the significance of teach-back and its risks, particularly if appearing to test or judge patients. After the intervention previous, subconscious use of teach-back evolved to a conscious and considered action, which could be withheld. Subsequently only those con1fortable with it used the technique managing impact on patient relationships. Sustainability of behavioural change was not assessed but needs consideration.

Conclusion: 'Textbook' examples of teach-back techniques were not well adopted. Participants understood the importance of teach-back to assess patients' understanding following intervention, but recognised it may upset or offend patients. Increased opportunity to explore variations of this strategy would allow staff to develop processes and phrases that suit their confidence level, personality and clientele. Peer feedback is also recommended.
Revealing Agile Mindset Using LEGO SERIOUS PLAY: Experience from an Online Agile Training Project (2022)

LEGO SERIOUS PLAY (LSP) is an effective methodology to enable the representation of abstract concepts and has been applied to teach several Software Engineering topics. However, there is limited evidence on how LSP can be used in training on agile mindset, which is the core and central element of agile methods. This paper demonstrates how LSP can be utilized in agile training to reveal the agile mindset of participants. We describe our experience of utilising LSP in an agile training project for local software companies. Since the project was run during the COVID-19 pandemic, we adapted the LSP methodology for online settings, which was not straightforward because face-to-face interactions and tangible objects are key characteristics of LSP. In this experience report, we describe the design of the online LSP workshops and explain how to analyze LSP models to reveal the agile mindset of the participants and to tailor the training accordingly. We also provide evidence of the effectiveness of the LSP methodology in our training project. Drawing upon our experience, we synthesize a set of lessons learned and sketch recommendations for educators who intend to apply LSP in their future endeavours.
Reduced natural killer cell activity in patients with systemic sclerosis (1988)

Natural killer (NK) cell number and function were determined in 69 systemic sclerosis (SSc) patients (41 with diffuse cutaneous SSc, 24 with limited cutaneous SSc, and 4 with scleroderma in an overlap syndrome). The results were compared with those obtained from 5 patients with Raynaud's disease and from 27 normal controls. Natural and antibody-dependent killing was reduced in the total group of SSc patients compared with controls, but these differences were primarily attributable to patients with the diffuse form of the disease who were seen early in their illness (less than 5 years after onset). NK cell numbers were not significantly reduced in patients compared with controls, although lower numbers were observed in individuals with early diffuse disease. Other clinical parameters, such as treatment with D-penicillamine or the presence of scleroderma-specific autoantibodies, did not exert an independent effect on NK cell function. These findings suggest a possible central role for NK cells in the pathogenesis of SSc.
Loss minimization in high-speed Permanent Magnet Synchronous Machines with tooth-coil windings (2013)

This paper investigates loss minimization in high-speed, low-power Permanent Magnet Synchronous Machines (PMSMs) with tooth-coil windings (TC-PMSMs). The influence of the main geometric parameters on the loss distribution is studied. Stator core and winding losses as well as rotor sleeve and permanent magnet (PM) losses are evaluated. The effect of the magnetic wedges on the loss distribution is examined. The machine working temperature and related PM demagnetization risks at the rated working point are presented for two- and three-phase short-circuits. The total losses of the designed PMSM are evaluated and a minimum total loss value is obtained.
On target: Rational approaches to KRAS inhibition for treatment of non-small cell lung carcinoma (2021)

Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer death. Approximately one-third of patients with NSCLC have a KRAS mutation. KRAS<sup>G12C</sup>, the most common mutation, is found in ~13% of patients. While KRAS was long considered 'undruggable', several novel direct KRAS<sup>G12C</sup> inhibitors have shown encouraging signs of efficacy in phase I/II trials and one of these (sotorasib) has recently been approved by the US Food and Drug Administration. This review examines the role of KRAS mutations in NSCLC and the challenges in targeting KRAS. Based on specific KRAS biology, it reports exciting progress, exploring the use of novel direct KRAS inhibitors as monotherapy or in combination with other targeted therapies, chemotherapy, and immunotherapy.
Cosecretion of peptides derived from gamma-human atrial natriuretic polypeptide in normal volunteers and patients with essential hypertension and adrenal disorders (1988)

Using two radio-immunoassays for N-terminal and C-terminal fragments of human atrial natriuretic polypeptide (ANP) precursor, gamma-hANP [human atrial natriuretic factor-(1-126)], that is gamma-hANP(1-25) [human atrial natriuretic factor-(1-25)] and alpha-hANP [human atrial natriuretic factor-(99-126)], we studied the secretion of gamma-hANP-derived peptides into circulation from the heart in normal subjects and patients with essential hypertension and adrenal disorders. Volume expansion with 2 litres physiological saline increased plasma gamma-hANP(1-25)-like immunoreactivity concomitantly with plasma alpha-hANP-like immunoreactivity in normal subjects. Infusion of angiotensin II (20 ng/kg per min) or noradrenaline (200 ng/kg per min) also caused a parallel increase in plasma gamma-hANP(1-25)-like and alpha-hANP-like immunoreactivity. Plasma gamma-hANP(1-25)-like immunoreactivity levels were changed together with alpha-hANP-like immunoreactivity in patients with essential hypertension and adrenal disorders. These results indicate that gamma-hANP-derived peptides, alpha-hANP and the 10-k N-terminal fragment of gamma-hANP (N-peptide) are cosecreted from the heart and that the simultaneous measurement of N-peptide and alpha-hANP serves as an indicator of the cardiac endocrine function. The significance of N-peptide as a hormone must await further clarification.
Stem Cell Factor Is Localized in, Released from, and Cleaved by Human Mast Cells (1999)

Stem cell factor (SCF) is the most important cytokine regulating human mast cell growth and functions. The immunogold technique showed SCF in the secretory granules of skin mast cells and in lung parenchymal mast cells (HLMC). Immunoreactive SCF (iSCF) was detected in cell lysates of HLMC, but not in basophils; iSCF and histamine were detected in supernatants of HLMC 3 min after challenge with anti-FcepsilonRI or anti-IgE, and iSCF in supernatants rapidly declined after 30 min, whereas histamine remained unchanged for 120 min. HPLC and electrospray mass spectrometry (ES/MS) analysis of recombinant human SCF1-166 (18,656. 9 +/- 0.9 Da) treated with chymase showed a polypeptide of 17,977.1 +/- 0.6 Da and a minor component of 697.4 +/- 0.1 Da generated by specific cleavage at Phe159. SCF1-166 and SCF1-159 similarly activated HLMC, potentiated anti-IgE-induced activation of these cells, and stimulated HLMC chemotaxis. SCF159-166 had no effect on mast cells. Western blot analysis of supernatants of anti-IgE-activated HLMC incubated with recombinant human SCF1-166 showed that SCF1-166 was rapidly cleaved to SCF1-159 and SCF1-144. Experiments with supernatants of anti-IgE-activated HLMC incubated with SCF1-166 yielded similar results. In conclusion, SCF is stored in mast cell secretory granules and is immunologically released by human mast cells. SCF1-166 is rapidly and specifically cleaved to SCF1-159 by chymase, which retains its biological effect on mast cells. SCF is also cleaved by other proteases to several SCF species whose possible biological activities remain to be established.
Comparisons of the simulated emissions and fuel efficiencies of diesel and gasoline hybrid electric vehicles (2011)

This paper presents results from gasoline- and diesel-powered hybrid electric vehicles (HEVs) and plug-in hybrid electric vehicles (PHEVs) that account for the interaction of drive cycle transients and engine start–stop events with after-treatment devices and their associated fuel penalties. These simulations were conducted using the Powertrain Systems Analysis Toolkit software combined with after-treatment component models developed at Oak Ridge National Laboratory. The present authors employed a three-way catalyst model for gasoline emissions control and a lean nitrogen oxide (NO x ) trap model to simulate diesel exhaust NO x reduction. A previously reported methodology based on experimentally calibrated corrections to steady state maps was used to simulate engine-out emissions and thermal variations. As expected, the simulations indicate a higher baseline fuel efficiency for diesel-powered hybrid vehicles, but this advantage is reduced by about a third for both HEVs and PHEVs when the fuel penalty for the lean NO x trap is included. These preliminary studies demonstrate that existing engine and exhaust systems models can capture important features of the highly transient engine operation in hybrid vehicles and can provide useful comparisons between advanced hybrid vehicle engine options.
Progesterone Represses Interleukin-8 and Cyclo-Oxygenase-2 in Human Lower Segment Fibroblast Cells and Amnion Epithelial Cells1 (2003)

Labor is preceded by cervical ripening through upregulation of interleukin (IL)-1beta, IL-8, and increased prostaglandin synthesis via inducible type 2 cyclooxygenase (COX-2). Progesterone maintains myometrial quiescence during pregnancy. In this study, we examined the effects of IL-1beta and progesterone on IL-8 and prostaglandin E2 (PGE2) synthesis and IL-8 and COX-2 mRNA and promoter activity in amnion cells and lower segment fibroblast (LSF) cells. In both cell types, progesterone had no effect on basal IL-8 or PGE2 synthesis. In LSF cells, IL-1beta significantly increased IL-8 and PGE2 synthesis and COX-2 and IL-8 mRNA expression, but progesterone significantly attenuated these effects. In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression. In postlabor amnion cells, IL-1beta increased IL-8 and PGE2 synthesis and COX-2 expression, but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis. Progesterone repression of IL-8 and COX-2 in LSF cells suggests that IL-8 and COX-2 have similar regulatory mechanisms in LSF cells and that progesterone may play a role in maintenance of cervical competence. The lack of effect of progesterone on IL-8 in postlabor cells may be the result of downregulation of the progesterone receptor during labor.
Extended depth-of-focus by digital holographic microscopy (2010)

A recurrent problem in microscopy is the finite depth-of-focus linked to the NA of microscope objectives. Digital holographic microscopy (DHM) has the unique feature of being able to numerically change the focus from a single hologram without the need of moving the sample. Extended depth of focus of amplitude images has been demonstrated, but it has marginal interest for the metrological application of DHM that needs the topography. In this Letter, we demonstrate that DHM is able to provide not only extended depth-of-focus amplitude images but extended focused complex data from which the topography is computed. For this purpose, reflection and transmission measurements on micro-optics (microlens and retroreflector) performed by using standard reconstruction or the extended focused complex data are compared. These experiments demonstrate that DHM measures, from a single hologram acquisition, the accurate sample topography on a numerically increased depth-of-focus.
AN IMMUNOLOGICAL APPROACH TO THE STUDY OF EVOLUTION OF TRYPSINS (1969)

Antibodies were prepared in rabbits against trypsins obtained from four different species-namely bovine, porcine, spiny Pacific dogfish, and starfish (Evasterias trochelii). Each of the antisera, or the immunoglobulin G fraction thereof, was tested for its capacity to react with each of the four enzymes. The immunological reaction was assessed by three different techniques-precipitin reaction, antigen binding capacity, and inhibitory effect of the antibodies on the proteolytic activity of the enzymes. In each case, the homologous enzyme gave the strongest reaction with its antiserum but the heterologous enzymes were also capable of reacting to an appreciable extent. The cross-precipitation was the least sensitive method, and gave relatively low values, whereas cross-inhibition and cross-binding of radioactively labeled antigens indicated high extent of cross-reaction between the various trypsins. The relative capacity of interaction of the four enzymes with the four antibodies could be related to the order in which these enzymes developed during evolution. Thus the "order" of similarity was bovine > porcine > dogfish > starfish.
Holographic optical coherence imaging of rat osteogenic sarcoma tumor spheroids (2004)

Holographic optical coherence imaging is a full-frame variant of coherence-domain imaging. An optoelectronic semiconductor holographic film functions as a coherence filter placed before a conventional digital video camera that passes coherent (structure-bearing) light to the camera during holographic readout while preferentially rejecting scattered light. The data are acquired as a succession of en face images at increasing depth inside the sample in a fly-through acquisition. The samples of living tissue were rat osteogenic sarcoma multicellular tumor spheroids that were grown from a single osteoblast cell line in a bioreactor. Tumor spheroids are nearly spherical and have radial symmetry, presenting a simple geometry for analysis. The tumors investigated ranged in diameter from several hundred micrometers to over 1 mm. Holographic features from the tumors were observed in reflection to depths of 500-600 microm with a total tissue path length of approximately 14 mean free paths. The volumetric data from the tumor spheroids reveal heterogeneous structure, presumably caused by necrosis and microcalcifications characteristic of some human avascular tumors.
Fish Skin Grafts with Omega-3 for Treatment of Chronic Wounds: Exploring the Role of Omega-3 Fatty Acids in Wound Healing and A Review of Clinical Healing Outcomes. (2022)

Chronic, non-healing wounds, such as diabetic foot ulcers and venous leg ulcers, have a significant economic impact on healthcare and are associated with elevated patient morbidity. Among the toolset of treatment options available to clinicians, skin grafts from other species (xenografts) are often used to promote wound closure. While porcine xenografts have been the most used skin xenograft over the years, acellular fish skin grafts from Atlantic cod (Gadus morhua) have steadily gained traction in usage. Unlike other skin grafts, acellular fish skin grafts have a substantial lipid profile primarily composed of omega-3 fatty acids, notably eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fish oil supplementation has been shown to result in faster rates of wound epithelialization, and omega 3 fatty acids provide barrier protection against bacteria and alter the inflammatory profile of wounds. EPA and DHA have been shown to have modulatory effects on the progression of wound healing. These characteristic omega-3 fatty acids and their metabolites alter skin physiology at a cellular and molecular level. Clinically, fish skin grafts continually demonstrate increased efficacy in treatment of wounds. When applied to non-responsive diabetic foot ulcers, acellular fish skin grafts have resulted in accelerated healing rates and significantly more fully healed wounds when compared to standard options. Here, we explore the role of omega-3 fatty acids in wound regeneration and repair, with particular focus on EPA and DHA. Then, we review clinical research outcomes to address notable clinical research studies and highlight the therapeutic potential of fish skin grafts with omega-3 as a treatment for chronic, non-healing wounds.
Speciation of Organometallic Compounds in Environmetal Samples by Gas Chromatography after Flow Preconcentration on Fullerenes and Nanotubes (2005)

The development of a simple speciation method for the determination of lead (trimethyllead(I), dimethyllead(II), triethyllead(I), and diethyllead(II)), mercury (methylmercury(I), ethylmercury(I), mercury(II)), and tin (n-butyltin(III), di-n-butyltin(II), tri-n-butyltin(I), tin(IV)) compounds in environmental samples was described. The potential of C70 fullerenes and multiwalled carbon nanotubes (MWNTs) as sorbents was investigated for the first time; this study revealed that there are no significant differences between them in terms of sensitivity, selectivity, precision, and reusability. Comparative studies showed that MWNTs and C60 and C70 fullerenes were superior to graphitized carbon black and RP-C18 for the extraction of the 11 compounds studied. The accuracy of the MWNT method was evaluated from recovery values with two standard reference coastal sediments, and good concordance in the results were obtained. Detection limits of 0.5-2 pg/mL were obtained when using a sorbent column containing 160 mg of MWNTs (sample breakthrough, 50 mL of water). The method was successfully applied to the determination of lead, mercury, and tin compounds in water and coastal sediment samples with satisfactory results.
Bio-efficacy of different group of insecticides against the major sucking pests complex of Bt-Cotton crop (2020)

The present experiments were conducted to evaluate different group of insecticide molecules as foliar application for their bio-efficacy against major sucking pests of Bt-Cotton crop at JNKVV, Zonal Agricultural Research Station Chandangaon Chhindwara during Kharif-2017 & Kharif-2018 with seven treatments and three replications. Over all two spray were carried out during both years and thus the data obtained revealed that the insecticide molecule Flonicamid 50 % WG@ 150 g/ha was found best for managing the major sucking pest viz. Aphids, jassids, whitefly and thrips of Bt-cotton crop followed by Thiamethoxam 25% WG @ 200 g/ha, Diafenthiuron 50% WP @ 600 g/ha and Fipronil 5% SC @1000 ml/ha were also found effective against the major sucking pests of Bt-cotton crop.
<title>Interactive visualization and manipulation of 3-D reconstructions for the planning of surgical procedures</title> (1992)

The requirements for 3-D reconstructions to be useful in a clinical environment include availability of the imaging and computing hardware; sophisticated and user-friendly software that can be used by physicians or technicians; robust data that can be efficiently segmented into clinically relevant structures; interactive speed; and the ability to manipulate the visualized structures for the simulation of surgical procedures. We have developed an efficient hardware, software, and application environment that fulfills these requirements and have initiated testing of its performance.
Can we image quantitatively complex models with rays? (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998Can we image quantitatively complex models with rays?Authors: Stéphane OpertoSheng XuGilles LambaréStéphane OpertoÉcole des Mines de Paris, France, Sheng XuÉcole des Mines de Paris, France, and Gilles LambaréÉcole des Mines de Paris, Francehttps://doi.org/10.1190/1.1820085 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820085FiguresReferencesRelatedDetailsCited ByTarget-oriented beamlet migration based on Gabor-Daubechies frame decompositionLing Chen, Ru-Shan Wu, and Yong Chen10 March 2006 | GEOPHYSICS, Vol. 71, No. 2Prestack Gaussian‐beam depth migrationN. Ross Hill7 February 2012 | GEOPHYSICS, Vol. 66, No. 4Can we quantitatively image complex structures with rays?M. Stéphane Operto, Sheng Xu, and Gilles Lambaré7 February 2012 | GEOPHYSICS, Vol. 65, No. 4 SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 06 Jan 2005 CITATION INFORMATION Stéphane Operto, Sheng Xu, and Gilles Lambaré, (1998), "Can we image quantitatively complex models with rays?," SEG Technical Program Expanded Abstracts : 1120-1123. https://doi.org/10.1190/1.1820085 Plain-Language Summary PDF DownloadLoading ...
Growth factors effects on preimplantation development of mouse embryos exposed to tumor necrosis factor alpha. (2005)

The success rates of assisted reproduction techniques are still unsatisfactory. Relatively few in vitro cultured embryos reach the blastocyst stage. The purpose of the study was to evaluate the protective potential of epidermal growth factor (EGF), insulin-like growth factors 1 and 2 (IGF-I, IGF-II) and stem cell factor (SCF) on in vitro development of pre-implantation mouse embryos exposed to tumor necrosis factor alpha (TNFalpha). C3B6F1 female mice were superovulated with 5 IU of pregnant mare serum gonadotropin (PMSG) and 48 h later with 5IU of equine chorionic gonadotropin (eCG). Following the second injection females were mated with DBA males. Two cell embryos were flushed out from the fallopian tubes 40 h after eCG administration. After retrieval, the embryos were divided into control and experimental media and incubated in groups of ten for 96 h (37 degrees C, 5%CO(2), in droplets of 50 microl under mineral oil). In the first part of experiment, the embryo development was tested in media containing EGF, IGF-I, IGF-II, SCF, TNF-alpha (1 to 1000 ng/ml). In the second part of the study, the development of embryos was examined in medium containing 100 ng/ml TNFalpha and one of following factors: IGF-I, IGF-II; EGF or SCF (100 ng/ml). During the culture embryos were examined at 24 hours intervals to assess the embryo development. Blastocyst rate was determined following 96 hours of culture. Evaluation of total blastocyst cell number (TB) and inner cell mass (ICM) was also performed. TNFalpha significantly reduced (p<0.05) the blastocyst rates as well as TB and ICM. The examined growth factors improved the development of embryos exposed to TNFalpha. Thus, in this study, the protective action of IGF-I and II, EGF and SCF against the detrimental influence of TNFalpha was demonstrated.