gebhart/patrepeval huggingface dataset:
RCMS: Rapid Cloud Migration Solution (2013)

Cloud has been rapidly and broadly discussed in the last several years, definitely it's been carried into practice by many enterprises due to its undoubted expectation. Plenty of corporations (IT or Non-IT) have chosen to provide their services through cloud. To reconsider providing the same or better services through cloud, the corporations will have to implement the reengineering of all their software services. During reengineering, how to rapidly migrate the applications into cloud and how to reconstruct the development framework and architecture is the key point of success, which have not be deeply researched over by the cloud vendors yet. So this paper proposes a rapid cloud migration solution (RCMS) which includes advanced migration strategy, complete security framework, rapid development process, highly automatic reengineering, guaranteed performance monitoring and flexible storage services. These features make the migration rapid and stable which are proved cost saving and easy-maintenance.
Muscle-Adipose Tissue Cross Talk (2017)

Exercise training results in adaptations to both skeletal muscle and white adipose tissue (WAT) and protects against metabolic disorders including obesity and type 2 diabetes. Exercise-induced adaptations include an altered profile of secreted proteins, both myokines (from skeletal muscle) and adipokines (from adipose tissue). These secreted proteins may act in an endocrine manner to facilitate tissue-to-tissue communication and "cross talk," likely working together to improve overall metabolic health. Some studies suggest that contracting skeletal muscles release myokines that may function to alter the phenotype of WAT, including WAT "beiging," in which there is increased expression of beige marker genes and increased presence of multilocular cells within the WAT.
Oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in relapsed diffuse large B-cell lymphoma (DLBCL): Final results of a phase II trial (2007)

18511 Background: Vorinostat (Zolinza™) is a histone deacetylase inhibitor (HDACI) approved in the US for the treatment of cutaneous manifestations in patients (pts) with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following 2 systemic therapies. Clinical responses with vorinostat have been reported in other lymphoma subtypes. Methods: Open-label, single-arm, nonrandomized Phase II trial of oral vorinostat 300 mg bid (initially 14 d/3 wks; amended to 3 d/wk) until disease progression or intolerable toxicity. Eligibility: measurable, relapsed/refractory DLBCL; = 2 prior systemic therapies; adequate hematologic, hepatic and renal function. Pts who had prior HDACI treatment, allogeneic transplant, or had failed &gt; 3 prior therapies were excluded. Primary endpoint: objective response rate (ORR) measured by CT/PET. Secondary endpoints: assessment of response duration (DOR), time to progression (TTP), time to response (TTR) and safety. Results: Eighteen pts (median age, 66 y [range, 59–86 y]; median 2 prior systemic therapies) were enrolled from 5/05 - 3/06 at 8 centers. Seven pts were initially treated with 300 mg bid 14 d/3 wks, but 4 had DLT (Gr 3 muscle spasms; Gr 4 thrombocytopenia, n = 3). The schedule was amended to 300 mg bid 3 d/wk and no other pt had DLT. One pt on the 3d/wk schedule achieved a CR (TTR = 85 d; DOR = 225+ d) and the ORR was 5.6%. One pt had SD for 301 d. Sixteen pts discontinued (DC) due to PD; median TTP for all pts was 44 d. Median number of treatment cycles was 2 (range, 1–14+). Two pts received &gt; 6 cycles (126 d). Common drug-related adverse experiences (AE; mostly = Gr 2) were diarrhea (61%), fatigue (50%), nausea (39%), anemia (33%) and vomiting (33%). Three pts had dose reduction (300 -&gt; 200 mg bid 14 d/3 wks) and none DC due to a drug-related AE. Drug-related AE = Gr 3 included thrombocytopenia (n = 3; 300 mg bid 14 d/3 wk) and asthenia (n = 2; 300 mg bid 3 d/wk). Two pts died on study of causes unrelated to drug: PD + GI hemorrhage (d 40) and acute myocardial infarction (d 95). Conclusion: Vorinostat has modest activity in pts with relapsed DLBCL and is well tolerated at 300 mg bid 3 d/wk or 200 mg bid 14 d/3 wks. The optimal dose/schedule and predictive response biomarkers require further study. No significant financial relationships to disclose.
Transepicardial or transendocardial injury: controversies regarding angiogenic potential and mechanism of action (2001)

Time for primary review 20 days. 

Over the past decade, surgical and now catheter-based approaches using various mechanical devices and energy sources aimed to enhance tissue perfusion are being explored as new adjunctive therapies in patients with refractory ischemic coronary disease [1,2]. It has been suggested that the likely mechanism associated with the initiation of angiogenesis is the induction of local inflammatory processes, and that tissue changes trigger endogenous expression of variety of angiogenic cytokines acting in concert to initiate and maintain microvessel formation (i.e. angiogenesis) [3]. The improved collateral pathways may change the local ischemic milieu in a way that may culminate in a long-standing therapeutic effect in selected patients. Since angiogenesis was assumed to be a primary mechanism associated with ‘direct’ myocardial revascularization (DMR) procedures, it has been termed ‘the mechanical approach for myocardial angiogenesis’. Nevertheless, the evidence for a therapeutically significant angiogenesis following mechanical myocardial injury is inconclusive.

In the current paper we attempt to review the myocardial response to various mechanical channeling and ablative energy sources being used in practice and/or clinical investigations. Data indicative for angiogenesis in response to direct myocardial injury or to a combination of energy sources with pro-angiogenic pharmacotherapy (i.e. ‘hybrid’ approaches) are also provided and critically assessed.

### 1.1 Myocardial tissue responses to mechanical injury

#### 1.1.1 Laser energy

Laser energy has specific tissue interactions that are fundamental to our ability to achieve a desirable tissue response and avoid unwarranted excessive myocardial damage. For example, unlike CO2 laser, which provides more precise ‘ablative’ characteristics with some collateral damage [4], the holmium (Ho):YAG laser (currently used in most catheter-based and several surgical DMR protocols) has profound photoacoustic effects and hence a marked thermal and photochemical impact on myocardial tissue [5,6]. Minimizing the energy being directly delivered to the myocardium may predominantly trigger natural tissue processes that may cause local … 

* Corresponding author. Tel.: +1-202-877-3321; fax: +1-202-877-2715 rxk3{at}mhg.edu
Occurrence of trona in alkaline soils of the IndoGangetic Plains of Uttar Pradesh (U.P.), India (2002)

Efflorescent crusts consisting predominantly of the sodium carbonate minerals trona (Na 2 CO 3 NaHCO 3 2H 2 O) with minor thermonatrite (Na 2 CO 3 H 2 O) are commonly developed on less vegetated portions of the Indo-Gangetic Plains of the state of Uttar Pradesh in India.
A 90 GHz Amplifier Assembled Using a Bump-Bonded InP-Based HEMT (1998)

We report on the performance of a novel W-band amplifier fabricated utilizing very compact bump bonds. We bump-bonded a high-speed, low-noise InP high electron mobility transistor (HEMT) onto a separately fabricated passive circuit having a GaAs substrate. The compact bumps and small chip size were used for efficient coupling and maximum circuit design flexibility. This new quasi-monolithic millimeter-wave integrated circuit (Q-MMIC) amplifier exhibits a peak gain of 5.8 dB at approx. 90 GHz and a 3 dB bandwidth of greater than 25%. To our knowledge, this is the highest frequency amplifier assembled using bump-bonded technology. Our bump-bonding technique is a useful alternative to the high cost of monolithic millimeter-wave integrated circuits (MMIC's). Effects of the bumps on the circuit appear to be minimal. We used the simple matching circuit for demonstrating the technology - future circuits would have all of the elements (resistors, via holes, bias lines, etc.) included 'in conventional MMIC's. Our design in different from other investigators' efforts in that the bumps are only 8 microns thick by 15 microns wide. The bump sizes were sufficiently small that the devices, originally designed for W-band hybrid circuits, could be bonded without alteration. Figure 3 shows the measured and simulated magnitude of S-parameters from 85-120 GHz, of the InP HEMT bump-bonded to the low noise amplifier (LNA) passive. The maximum gain is 5.8 dB at approx. 90 GHz, and gain extends to 117 GHz. Measurement of a single device (without matching networks) shows approx. 1 dB of gain at 90 GHz. The measured gain of the amplifier agrees well with the design in the center of the measurement band, and the agreement falls off at the band edges. Since no accommodation for the bump-bonding parasitics was made in the design, the result implies that the parasitic elements associated with the bonding itself do not dominate the performance of the LNA circuit. It should be noted that this amplifier was designed for good noise performance, which is why the input and output return losses are poorer than one would expect for an amplifier simply matched for gain. However, noise performance has not been measured at this time. While the agreement between modeled vs. experimental data is not exact, the data prove that bump-bonded technology can be used for amplifiers at frequencies at least as high as 100 GHz. JPL is pursuing this technology as a way to economically and quickly incorporate the best available HEMTs into a circuit with all of the reliability and circuit design flexibility offered by MMIC technology. We are currently using the technology to fabricate 4-stage, wide-band, W-band LNA's. We have also performed pull and shear tests which show that the bump bonds are sufficiently robust for any anticipated application.
Biliary tract large cell neuroendocrine carcinoma: current evidence (2019)

The prognosis of hepatobiliary LCNEC remains poor with median survival of only 11 months from initial diagnosis. Studies focusing on high grade neuroendocrine carcinoma are needed to enhance our understanding of biology and therapeutics in this rare but aggressive cancer.
Bioactive Lignans from the Trunk of Abies holophylla (2013)

Six new lignans (1-6) were isolated from the trunk of Abies holophylla MAXIM, together with 11 known lignans (7-17). The structures of 1-7 were elucidated by spectroscopic methods, acid hydrolysis, and use of the modified Mosher's method. The effects of the isolates on nerve growth factor induction in a C6 rat glioma cell line were evaluated. Compounds 6, 7, and 13 showed significant induction of nerve growth factor secretion at concentrations of 10 μM. Compounds 1, 5, 6, and 16 showed moderate inhibitory effects on nitric oxide production in lipopolysaccharide-activated BV-2 cells (IC50 28.5-36.4 μM).
Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing (2016)

Mechanical and structural changes of right ventricular (RV) in response to pulmonary hypertension (PH) are inadequately understood. While current standard biaxial testing provides information on the mechanical behavior of RV tissues using surface markers, it is unable to fully assess structural and mechanical properties across the full tissue thickness. In this study, the mechanical and structural properties of normotensive and pulmonary hypertension right ventricular (PHRV) myocardium through its full thickness were examined using mechanical testing combined with 3D ultrasound speckle tracking (3D-UST). RV pressure overload was induced in Sprague-Dawley rats by pulmonary artery (PA) banding. The second Piola-Kirchhoff stress tensors and Green-Lagrangian strain tensors were computed in the RV myocardium using the biaxial testing combined with 3D-UST. A previously established non-linear curve-fitting algorithm was applied to fit experimental data to a Strain Energy Function (SEF) for computation of myofiber orientation. The fiber orientations obtained by the biaxial testing with 3D-UST compared well with the fiber orientations computed from the histology. In addition, the re-orientation of myofiber in the right ventricular free wall (RVFW) along longitudinal direction (apex-to-outflow-tract direction) was noticeable in response to PH. For normotensive RVFW samples, the average fiber orientation angles obtained by 3D-UST with biaxial test spiraled from 20° at the endo-cardium to -42° at the epi-cardium (Δ = 62°). For PHRV samples, the average fiber orientation angles obtained by 3D-UST with biaxial test had much less spiral across tissue thickness: 3° at endo-cardium to -7° at epi-cardium (Δ = 10°, P<0.005 compared to normotensive).
Sulfated Alginate as an Effective Polymer Binder for High-Voltage LiNi0.5Mn1.5O4 Electrodes in Lithium-Ion Batteries (2022)

Although the increasing demand for high-energy-density lithium-ion batteries (LIBs) has inspired extensive research on high-voltage cathode materials, such as LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> (LNMO), their commercialization is hindered by problems associated with the decomposition of common carbonate solvent-based electrolytes at elevated voltages. To address these problems, we prepared high-voltage LNMO composite electrodes using five polymer binders (two sulfated and two nonsulfated alginate binders and a poly(vinylidene fluoride) conventional binder) and compared their electrochemical performances at ∼5 V vs Li/Li<sup>+</sup>. The effects of binder type on electrode performance were probed by analyzing cycled electrodes using soft/hard X-ray photoelectron spectroscopy and scanning transmission electron microscopy. The best-performing sulfated binder, sulfated alginate, uniformly covers the surface of LNMO and increased its affinity for the electrolyte. The electrolyte decomposition products generated in the initial charge-discharge cycle on the alginate-covered electrode participated in the formation of a protective passivation layer that suppressed further decomposition during subsequent cycles, resulting in enhanced cycling and rate performances. The results of this study provide a basis for the cost-effective and technically undemanding fabrication of high-energy-density LIBs.
Prognostics framework [for weapon systems health monitoring] (1999)

US Army Policy is outpacing technology capability in the requirements for systems' prognostics. During the past five years, research and development (R&D) has been ongoing in the area of component prognostic techniques in laboratories, universities, and industry. The R&D has resulted in point solutions to specific items, but in general, they are expensive and provide limited system-level information. The US Army Logistics Integration Agency has funded the development of a "Prognostics Framework". This "Prognostics Framework" is generic, open architecture, horizontal technology, and tailorable. The Prognostics Framework approach will save time, money, and program-specific funds. It is the fastest way to converge various prognostics capabilities into manageable information for the system operators, the maintenance crew, and logistics planners across Army systems. The Prognostic Framework, a system-level prognostic manager, ties-in to logistics infrastructure, (e.g., IETM, logistics planning, mission planning, and spare parts provisioning). Prognostics Framework will be integrated with embedded diagnostics to provide a total "Health Management" capability. This paper will provide the initial information about Prognostics Framework architecture, design approach, and a brief summary of the prognostic mechanisms survey.
J0204-1-4 Study on evaluation of muscle conditionsusing a mechanomyogram sensor (2009)

In this study, a mechanomyogram (MMG) sensor system for monitoring muscle conditions is developed. The polyvinylidene fluoride (PVDF) film is used as the sensory receptor of the MMG sensor. The sensor performance is verified by the fundamental experiment. The results show that the mean power frequency (MPF) of the sensor output is related to firing rate of action potential (AP) of muscle and the variance of the sensor output is related to the activity of fast fibers and complete recruitment. Next, muscle activities of isometric contraction are studied using the developed MMG sensor before and after muscle fatigue. Measurements were conducted on biceps and triceps brachii of healthy subjects with load. Experimental results show that contraction of fast fibers is occurred earlier and fast fibers activity increase earlier due to muscle fatigue. Focusing on the time shift of local maximum point in MPF and decrease of growth rate in variance, parameters for evaluation of muscle fatigue degree are proposed.
Appreciating the variety of goals in computational neuroscience (2020)

Within computational neuroscience, informal interactions with modelers often reveal wildly divergent goals. In this opinion piece, we explicitly address the diversity of goals that motivate and ultimately influence modeling efforts. We argue that a wide range of goals can be meaningfully taken to be of highest importance. A simple informal survey conducted on the Internet confirmed the diversity of goals in the community. However, different priorities or preferences of individual researchers can lead to divergent model evaluation criteria. We propose that many disagreements in evaluating the merit of computational research stem from differences in goals and not from the mechanics of constructing, describing, and validating models. We suggest that authors state explicitly their goals when proposing models so that others can judge the quality of the research with respect to its stated goals.
Subject-oriented programming (1993)

Object-Oriented technology is often described in terms of an interwoven troika of themes: encapsulation, polymorphism, and inheritance. But these themes are firmly tied with the concept of identity. If object-oriented technology is to be successfully scaled from the development of independent applications to development of integrated suites of applications, it must relax its emphasis on the objecf. The technology must recognize more directly that a multiplicity of subjective views delocalizes the concept of object, and must emphasize more the binding concept of identity to tie them together. This paper explores this shift to a style of objectoriented technology that emphasizes the subjective views: Subject-
A Dosimetry Methodology for Two-Photon Absorption Induced Single-Event Effects Measurements (2014)

A pulsed-laser dosimetry approach for two-photon absorption (TPA) single-event effects (SEE) measurements is presented. Development and implementation of three online beam monitors is described. The beam monitors permit characterization of the primary laser beam parameters of interest: the pulse energy delivered to the device under test, the pulse duration, and the focused laser spot size. A direct consequence of this methodology is the ability to monitor continuously the operating point of the TPA SEE pulsed-laser beamline and to make the necessary adjustments when parameters drift, either during an experiment or between experiments.
An insulin delivery system from oxidized cellulose (1981)

Cellulose oxidized with periodate (OC) has been shown to be a biocompatible, biodegradable matrix suitable for immobilization and sustained release of drugs. In the present work, insulin was immobilized on the OC-matrix and the release profile in vivo and in vitro was examined. The hormone is bound to the matrix by Schiff's bond formation and is released by hydrolysis of this bond as well by degradation of the OC-matrix. The release can be sustained over longer periods by reducing the Schiff's base with NaBH4. The insulin depots could be conveniently injected as suspensions and are able to maintain glucose levels in diabetized rabbits at normal values over several days.
Applying IDC theory to education in the Alps region: a response to Chan et al.’s contribution (2019)

Abstract In this paper, we present a response to the Interest-Driven Creator (IDC) theory from a European perspective. Specifically, we raise six questions intended to start a dialog with respect to IDC theory’s placement in existing learning theories, its adoption in educational systems, and how it can be influenced by emerging learning technologies and digitalization, which is currently a driving force in the Alps region. By referring to our own work in vocational education and classroom orchestration, we demonstrate how IDC can begin to play a part in guiding innovations and its potential impact on education both in and outside of Asia. With respect to digitalization, rather than allowing technological innovations to fully guide educational decisions, we call for IDC theory to be part of the conversation to help guide future educational designs.
Modifications of the cyclic mu receptor selective tetrapeptide Tyr‐c[d‐Cys‐Phe‐d‐Pen]NH2 (Et): effects on opioid receptor binding and activation (2000)

The previously described cyclic mu opioid receptor-selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et) (JOM-6) was modified at residues 1 and 3 by substitution with various natural and synthetic amino acids, and/or by alteration of the cyclic system. Effects on mu and delta opioid receptor binding affinities, and on potencies and efficacies as measured by the [35S]-GTPgammaS assay, were evaluated. Affinities at mu and delta receptors were not influenced dramatically by substitution of Tyr1 with conformationally restricted phenolic amino acids. In the [35S]-GTPgammaS assay, all of the peptides tested exhibited a maximal response comparable with that of fentanyl at the mu opioid receptor, and all showed high potency, in the range 0.4-9nM. However, potency changes did not always correlate with affinity, suggesting that the conformation required for binding and the conformation required for activation of the opioid receptors are different. At the delta opioid receptor, none of the peptides were able to produce a response equivalent to that of the full delta agonist BW 373,U86 and only one had an EC50 value of less than 100nM. Lastly, we have identified a peptide, D-Hat-c[D-Cys-Phe-D-Pen]NH2 (Et), with high potency and > 1,000-fold functional selectivity for the mu over delta opioid receptor as measured by the [35S]-GTPgammaS assay.
Republished: Successful treatment of direct carotid–cavernous fistula in a patient with Ehlers–Danlos syndrome type IV without arterial puncture: the transvenous triple-overlay embolization (TAILOREd) technique (2020)

We report successful transvenous treatment of direct carotid-cavernous fistula in a patient with Ehlers-Danlos syndrome type IV using a novel triple-overlay embolization (TAILOREd) technique without the need for arterial puncture, which is known to be highly risky in this patient group. The TAILOREd technique allowed for successful treatment using preoperative MR angiography as a three-dimensional overlay roadmap combined with cone beam CT and live fluoroscopy, precluding the need for an arterial puncture.