gebhart/patrepeval huggingface dataset:
Coronary Artery Bypass in Totally Obstructed Major Coronary Arteries (1971)

Of 278 patients undergoing aorto-coronary artery bypass grafts through July 1970, a total of 167 (62.2%) had 220 complete occlusions of one or more major coronary arteries. The right coronary artery (RCA) was occluded in 61%, the left anterior descending (LAD) in 28%, the left circumflex (LCA) in 10%, and the left main (LM) in less than 1%. Previous myocardial infarctions, congestive heart failure, incapacitation, and elevated left ventricular end diastolic pressure were more common in this group than in those with stenotic lesions. The RCA was most often suitable for bypass graft, followed by the LAD, and lastly the LCA. In the small group without demonstrable distal collaterals on arteriograms, distal bypasses were done successfully beyond 70% of the occluded RCAs, 51% of the LADs, and none of the LCAs. Operative mortality (30 days) was only 3% higher in the occluded than in the stenotic group. Postoperative angiographic patency rates were the same.
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells (2016)

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastrointestinal stromal tumor, acute myeloid leukemia, melanoma, and other tumors, and these results have encouraged attempts toward improvement of using c-Kit as a capable target for cancer therapy. This paper presents the findings of previous studies regarding c-Kit as a receptor tyrosine kinase and an oncogene, as well as its gene targets and signaling pathways in normal and cancer cells. The c-Kit gene location, protein structure, and the role of c-Kit in normal cell have been discussed. Comprehending the molecular mechanism underlying c-Kit-mediated tumorogenesis is consequently essential and may lead to the identification of future novel drug targets. The potential mechanisms by which c-Kit induces cellular transformation have been described. This study aims to elucidate the function of c-Kit for future cancer therapy. In addition, it has c-Kit inhibitor drug properties and their functions have been listed in tables and demonstrated in schematic pictures. This review also has collected previous studies that targeted c-Kit as a novel strategy for cancer therapy. This paper further emphasizes the advantages of this approach, as well as the limitations that must be addressed in the future. Finally, although c-Kit is an attractive target for cancer therapy, based on the outcomes of treatment of patients with c-Kit inhibitors, it is unlikely that Kit inhibitors alone can lead to cure. It seems that c-Kit mutations alone are not sufficient for tumorogenesis, but do play a crucial role in cancer occurrence.
Supplementary Data from Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype (2023)

&lt;p&gt;SI Methods and legends&lt;/p&gt;
Tapping into the Influence of Keratinocyte Allografts and Biocenosis on Healing of Chronic Leg Ulcers: Split-Ulcer Controlled Pilot Study (2006)

In this small case series, it appears that cultured allogeneic keratinocytes may be helpful in the healing process of venous leg ulcers. However, a clean wound with reduced bacterial load seems to be the prerequisite condition for obtaining a beneficial effect.
Promoting the participation of adults with acquired hearing impairment in their rehabilitation (2010)

The aim of this tutorial is to review approaches that promote client participation in health care. More specifically, client-centeredness, joint goal setting, and shared decision making are defined ...
EXTH-35. SYNERGISTIC EFFECT OF TARGETING THIOREDOXIN REDUCTASE (TRX1) AND DEPLETION OF GLUTATHIONE SYSTEM (GSH) IN GLIOBLASTOMA STEM CELLS (2020)

Abstract Glioblastoma (GBM), the most common and advanced malignant primary brain tumor in adults remains incurable. GBM tumor recurrence occurs within a short time reflecting the failure to eradicate chemo-radioresistant GBM stem cells (GSCs). GSCs alter the redox system including Thioredoxin (Trx) and glutathione (GSH) systems to counteract increased reactive oxygen species (ROS). We previously showed the role of O6-methylguanine-DNA methyltransferase (MGMT) in response to PRIMAMET, a drug that targets the TP53 tumor suppressor gene and decrease Thioredoxin reductase1 (TRxR1) levels and further identified a positive relationship between MGMT and TrxR1 in established GBM cell lines isogenic for MGMT. Auranofin (Au), an orally available ROS-inducing FDA-approved drug is a potent irreversible inhibitor of TrxR1. The effect of Au on GSCs and the potential relationship between TrXR1, MGMT and p53 specifically in GSCs remain unknown. We hypothesized that increased ROS levels in GSCs might affect their drug resistant phenotype. we investigated the cytotoxic effects of Au on GSCs with known MGMT and P53 status and the mechanisms underlying these effects. Our results suggest that Au exerts strong cytotoxic effects in GSCs within a micromolar range. These effects were associated with increased ROS levels, decreased TrXR1, MGMT, phosphorylation of ERk1/2, activation of p53 and increased apoptosis, we also used a knockdown strategy to assess the role of p53 and showed that increased sensitivity to Au for p53-knockdown. We showed the role of ROS in response to Au using ROS inducer L-Buthionine Sulfoxamine (L-BSO), a GSH inhibitor, and ROS scavenger N-Acetylcysteine (NAc). L-BSO combined with Au drastically decreased the IC50 within a nanomolar range suggesting the crucial role of both Trx and GSH systems in GSCs redox balance. Increased ROS with concomitant GSH depletion using L-BSO might circumvent drug-induced oxidative stress and overcome drug resistance in MGMT-positive and negative GSCs
Nucleophilic Addition onto Methyl-4H-1,4-oxazine-3-carboxylate Moiety: Short Access to 1,4-Diazine Privileged Substructures (2009)

To determine the synthetic potential of the original 1,4-oxazine ring, which appears as a valuable building block for the synthesis of more complex derivatives, Michael-type nucleophilic additions were studied. According to the nature of the nucleophile, either acyclic or cyclic derivatives were isolated. In the presence of primary amines, a short and efficient access to diazinic hemiaminals was described.
Enhancing mobile services with DVB‐S2X superframing (2018)

Summary DVB‐S2X is the cornerstone for satellite communication standards forming the state of the art of broadband satellite waveforms. In this paper, we propose new application scenarios and advanced techniques, including a reference design implementing superframing, predistortion, a robust synchronization chain, and a plug‐and‐play channel interleaver. We demonstrate by means of software simulations and hardware tests that the DVB‐S2X can be a common technology enabler for land‐mobile, aeronautical, and maritime satellite scenarios in addition to the more traditional VSAT scenario, even in very challenging conditions (eg, very low signal‐to‐noise ratio).
Declarative Probabilistic Programming with Datalog (2014)

Probabilistic programming languages are used for developing statistical models, and they typically consist of two components: a specification of a stochastic process (the prior), and a specification of observations that restrict the probability space to a conditional subspace (the posterior). Use cases of such formalisms include the development of algorithms in machine learning and artificial intelligence. We propose and investigate an extension of Datalog for specifying statistical models, and establish a declarative probabilistic-programming paradigm over databases. Our proposed extension provides convenient mechanisms to include common numerical probability functions; in particular, conclusions of rules may contain values drawn from such functions. The semantics of a program is a probability distribution over the possible outcomes of the input database with respect to the program. Observations are naturally incorporated by means of integrity constraints over the extensional and intensional relations. The resulting semantics is robust under different chases and invariant to rewritings that preserve logical equivalence.
Small and Bright: Nanodiamonds for tissue repair, drug delivery, and biodetection (2014)

Transforming diamond sizes from the micron regime into a few billionths of a meter probably doesn't increase their value in jewelry, but it certainly adds an extraordinary value in numerous physical science, engineering, and medical applications. Nanodiamonds are generally defined as synthetic diamond materials that have crystalline or feature sizes (e.g., grain or particle sizes) between 1 and 100 nm (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> m) and include two forms: particulate (zero-dimensional) and thin film (two-dimensional). Figure 1 shows particulate nanodiamond (PND) and nanodiamond thin films under a scanning electron microscope (SEM) and atomic force microscope (AFM). Because the nanodiamond thin film is actually composed of nanosized columnar crystals or grains, the material is usually called nanocrystalline diamond (NCD) or ultra-NCD (UNCD, grains sizes <;10 nm).
On the pattern of gonadal development of the sea urchin, Diadema setosum off the coast of Singapore (2020)

18 collections of the sea urchin, Diadema setosum were made from coral reefs of islands off the coast of Singapore from July 1982 to July 1983. 9–36 sea urchins were collected on each occasion. The number of males exceeded that of the females in the most samples. The sea urchins were induced to spawn with isotonic KCl solution after which the specimens for histological observation were taken from the gonad to study oogenesis and spermatogenesis.
Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry (2018)

In an early stage of DR, supplementation with high-dose DHA plus xanthophyll carotenoid multivitamin during 90 days was associated with a progressive and significant improvement of macular function measured by microperimetry. Biochemical changes supported the effect of DHA.
IDEALIST control and service management solutions for dynamic and adaptive flexi-grid DWDM networks (2013)

Wavelength Switched Optical Networks (WSON) were designed with the premise that all channels in a network have the same spectrum needs, based on the ITU-T DWDM grid. However, this rigid grid-based approach is not adapted to the spectrum requirements of the signals that are best candidates for long-reach transmission and high-speed data rates of 400Gbps and beyond. An innovative approach is to evolve the fixed DWDM grid to a flexible grid, in which the optical spectrum is partitioned into fixed-sized spectrum slices. This allows facilitating the required amount of optical bandwidth and spectrum for an elastic optical connection to be dynamically and adaptively allocated by assigning the necessary number of slices of spectrum. The ICT IDEALIST project will provide the architectural design, protocol specification, implementation, evaluation and standardization of a control plane and a network and service management system. This architecture and tools are necessary to introduce dynamicity, elasticity and adaptation in flexi-grid DWDM networks. This paper provides an overview of the objectives, framework, functional requirements and use cases of the elastic control plane and the adaptive network and service management system targeted in the ICT IDEALIST project.
Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans (2007)

Motor responses evoked by stimulating the spinal cord percutaneously between the T11 and T12 spinous processes were studied in eight human subjects during walking and running. Stimulation elicited responses bilaterally in the biceps femoris, vastus lateralis, rectus femoris, medial gastrocnemius, soleus, tibialis anterior, extensor digitorum brevis and flexor digitorum brevis. The evoked responses were consistent with activation of Ia afferent fibres through monosynaptic neural circuits since they were inhibited when a prior stimulus was given and during tendon vibration. Furthermore, the soleus motor responses were inhibited during the swing phase of walking as observed for the soleus H-reflex elicited by tibial nerve stimulation. Due to the anatomical site and the fibre composition of the peripheral nerves it is difficult to elicit H-reflex in leg muscles other than the soleus, especially during movement. In turn, the multisegmental monosynaptic responses (MMR) technique provides the opportunity to study modulation of monosynaptic reflexes for multiple muscles simultaneously. Phase-dependent modulation of the MMR amplitude throughout the duration of the gait cycle period was observed in all muscles studied. The MMR amplitude was large when the muscle was activated whereas it was generally reduced, or even suppressed, when the muscle was quiescent. However, during running, there was a systematic anticipatory increase in the amplitude of the MMR at the end of swing in all proximal and distal extensor muscles. The present findings therefore suggest that there is a general control scheme by which the transmission in the monosynaptic neural circuits is modulated in all leg muscles during stepping so as to meet the requirement of the motor task.
ChemInform Abstract: Supported Metal Hydroxides as Efficient Heterogeneous Catalysts for Green Functional Group Transformations (2015)

Abstract Review: 65 refs.
Respiratory Francisella tularensis Live Vaccine Strain Infection Induces Th17 Cells and Prostaglandin E2, Which Inhibits Generation of Gamma Interferon-Positive T Cells (2020)

Two key routes of Francisella tularensis infection are through the skin and airway. We wished to understand how the route of inoculation influenced the primary acute adaptive immune response. We show that an intranasal inoculation of the F. tularensis live vaccine strain (LVS) with a 1,000-fold-smaller dose than an intradermal dose results in similar growth kinetics and peak bacterial burdens. In spite of similar bacterial burdens, we demonstrate a difference in the quality, magnitude, and kinetics of the primary acute T-cell response depending on the route of inoculation. Further, we show that prostaglandin E2 secretion in the lung is responsible for the difference in the gamma interferon (IFN-γ) response. Intradermal inoculation led to a large number of IFN-γ+ T cells 7 days after infection in both the spleen and the lung. In contrast, intranasal inoculation induced a lower number of IFN-γ+ T cells in the spleen and lung but an increased number of Th17 cells in the lung. Intranasal infection also led to a significant increase of prostaglandin E2 (PGE2) in the bronchoalveolar lavage fluid. Inhibition of PGE2 production with indomethacin treatment resulted in increased numbers of IFN-γ+ T cells and decreased bacteremia in the lungs of intranasally inoculated mice. This research illuminates critical differences in acute adaptive immune responses between inhalational and dermal infection with F. tularensis LVS mediated by the innate immune system and PGE2.
The Immunogenicity of the Influenza, Pneumococcal, and Hepatitis B Vaccines in Patients With Inflammatory Bowel Disease Treated With Vedolizumab (2020)

The inability to observe a response to the influenza vaccine was influenced by high baseline titers. For the hepatitis B vaccine, patients treated with vedolizumab experienced immunogenic response to vaccination that was noninferior to nonimmunosuppressed controls. All studied vaccines were well-tolerated. Vaccination should be encouraged in all adult patients with IBD.
My Father Knows. Sacred Song, with Pianoforte Accompaniment (1870)

TlIE MIJSICAL TIMES AInslJsT 1
Energy Sources of the Depth-Generalist Mixotrophic Coral Stylophora pistillata (2020)

Energy sources of corals, ultimately sunlight and plankton availability, change dramatically from shallow to mesophotic (30-150 m) reefs. Depth-generalist corals, those that occupy both of these two distinct ecosystems, are adapted to cope with such extremely diverse conditions. In this study, we investigated the trophic strategy of the depth-generalist hermatypic coral <i>Stylophora pistillata</i> and the ability of mesophotic colonies to adapt to shallow reefs. We compared symbiont genera composition, photosynthetic traits and the holobiont trophic position and carbon sources, calculated from amino acids compound-specific stable isotope analysis (AA-CSIA), of shallow, mesophotic and translocated corals. This species harbors different Symbiodiniaceae genera at the two depths: <i>Cladocopium goreaui</i> (dominant in mesophotic colonies) and <i>Symbiodinium microadriaticum</i> (dominant in shallow colonies) with a limited change after transplantation. This allowed us to determine which traits stem from hosting different symbiont species compositions across the depth gradient. Calculation of holobiont trophic position based on amino acid δ<sup>15</sup>N revealed that heterotrophy represents the same portion of the total energy budget in both depths, in contrast to the dogma that predation is higher in corals growing in low light conditions. Photosynthesis is the major carbon source to corals growing at both depths, but the photosynthetic rate is higher in the shallow reef corals, implicating both higher energy consumption and higher predation rate in the shallow habitat. In the corals transplanted from deep to shallow reef, we observed extensive photo-acclimation by the Symbiodiniaceae cells, including substantial cellular morphological modifications, increased cellular chlorophyll a, lower antennae to photosystems ratios and carbon signature similar to the local shallow colonies. In contrast, non-photochemical quenching remains low and does not increase to cope with the high light regime of the shallow reef. Furthermore, host acclimation is much slower in these deep-to-shallow transplanted corals as evident from the lower trophic position and tissue density compared to the shallow-water corals, even after long-term transplantation (18 months). Our results suggest that while mesophotic reefs could serve as a potential refuge for shallow corals, the transition is complex, as even after a year and a half the acclimation is only partial.
Tagesschwankungen des Ionengehalts in Salicornia europaea in Abhängigkeit vom Standort und von der Überflutung1 (1968)

Zusammenfassung . Salicornia europaea zeigt eine vom Standort abhängige Konzentration der Natrium‐ und Chloridionen im Preßsaft der Sprosse. Sie liegt für überflutete (Graben‐) Pflanzen niedriger als für nicht überflutete (Bult‐) Pflanzen. . Zu Beginn der Vegetationsperiode (Juni) beträgt das Verhältnis Na: Cl bei Grabenpflanzen 1:1,1 und bei Bultpflanzen 1:0,8 (Meerwasser 1:1,2). Zur Blütezeit im August liegt das Verhältnis bei Grabenpflanzen immer noch bei 1:1,1, während es sich bei Bultpflanzen auf 1:1 eingestellt hat. . Die Konzentration von Natrium und Chlorid verringert sich in den Sprossen beider Pflanzentypen zur Flutzeit, obwohl nur die Grabenpflanzen in ihren oberirdischen Teilen unter Wasser gelangen. . Es wird vermutet, daß die Natrium‐ und Chloridionen von den Sprossen in die Wurzeln verlagert und dort ausgewaschen werden.
Mathematical analysis of behavior systems (2005)

A behavior system consists of the components and control programs necessary to establish a particular behavior in a robotic agent. The paper proposes a mathematical approach for the analysis of behavior systems. The approach rests on viewing a behavior system as a dynamical system whose equilibrium state is attained when the behavior it is responsible for is achieved.
Properties of Misaligned Journal Bearings (1957)

Abstract Properties of misaligned journal bearings under hydrodynamic conditions of lubrication are presented as observed from experimental data. Curves in dimensionless form give journal-bearing attitude as a function of the usual bearing variables and the couples which produce misalignment. Examples are given showing the application of the dimensionless curves to typical problems of misaligned bearings.
Meson-Nucleon Scattering in the Tamm-Dancoff Approximation (1954)

An attempt is made to calculate meson-nucleon scattering by using charge-symmetric pseudoscalar meson theory with pseudoscalar coupling and without the use of perturbation theory. The Tamm-Dancoff formalism is used, with all states which are not directly coupled to the one-meson, one-nucleon state omitted. In this approximation an inhomogeneous integral equation in three-dimensional momentum space is derived for $g(\mathrm{p})$, the probability amplitude for relative momentum p between meson and nucleon. This equation is reduced to a separate one-dimensional integral equation for each of the six angular momentum and isotopic spin ($T$) states, ${S}_{\frac{1}{2}}$, ${P}_{\frac{1}{2}}$, and ${P}_{\frac{3}{2}}$ for $T=\frac{1}{2}, \frac{3}{2}$. The phase shifts for these states are given by the value of $g(p)$ on the energy-shell.All self-energy and renormalization terms are omitted and the present method is inapplicable to the two states of total angular momentum and $T$ equal to \textonehalf{}. The integral equations are solved by semi-numerical methods for the ${S}_{\frac{1}{2}}$ and ${P}_{\frac{3}{2}}$ states with $T=\frac{3}{2}$, obtaining the shape of $g(p)$ and the variation of phase shift with energy and coupling constant. It is shown that only for the ${P}_{\frac{3}{2}}$, $T=\frac{3}{2}$ (corresponding to an attractive potential) is the phase shift much larger than in Born approximation and depends strongly on the coupling constant and on energy. For the other, repulsive, states the phase shift is less than in Born approximation. For energies of about 150 Mev or more and for a large enough coupling constant, the ${P}_{\frac{3}{2}}$, $T=\frac{3}{2}$ phase shift is larger than any of the others. This is in rough qualitative (but by no means quantitative) agreement with experiment.
A Randomised, Double-Blind, Controlled Vaccine Efficacy Trial of DNA/MVA ME-TRAP Against Malaria Infection in Gambian Adults (2004)

DNA/MVA heterologous prime-boost vaccination is safe and highly immunogenic for effector T cell induction in a malaria-endemic area. But despite having produced a substantial reduction in liver-stage parasites in challenge studies of non-immune volunteers, this first generation T cell-inducing vaccine was ineffective at reducing the natural infection rate in semi-immune African adults.
Position control Of BLDC motor with modified bipolar PWM for clutch system Of PHEV (2013)

Generally, PHEV(plug-in hybrid electric vehicle) is driven by the engine, the primary traction motor, and the secondary auxiliary motor generating the electric power for battery charging. Secondary auxiliary motor should be connected to the engine or separated from the engine by the clutch system. This paper presents the position controller using BLDC motor for the clutch system of PHEV. BLDC motor can be applied to the clutch system in spite of it's low resolution of the position sensor due to high gear ratio between the clutch and the motor. Since the attachment and the detachment between the motor and the engine should be carried out within 0.3 seconds, the position controller with fast acceleration and deceleration must be implemented. For the torque control with braking operation for the BLDC motor, the modified bipolar PWM method with low current ripple compared to the conventional unipolar PWM is proposed. The position control performance of the BLDC motor for clutch system is verified through the simulation and experiments.