gebhart/patrepeval huggingface dataset:
Hydrobenzo[b]quinolizines. II.1 The Synthesis and Stereochemistry of Derivatives of 1,3,4,11a-Tetrahydro-8,9-dimethoxy-2H-benzo[b]quinolizin-11(6H)-one2 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrobenzo[b]quinolizines. II.1 The Synthesis and Stereochemistry of Derivatives of 1,3,4,11a-Tetrahydro-8,9-dimethoxy-2H-benzo[b]quinolizin-11(6H)-one2S. Morris Kupchan, A. D. J. Balon, and C. George DeGraziaCite this: J. Org. Chem. 1966, 31, 6, 1713–1716Publication Date (Print):June 1, 1966Publication History Published online1 May 2002Published inissue 1 June 1966https://pubs.acs.org/doi/10.1021/jo01344a011https://doi.org/10.1021/jo01344a011research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cross correlation of neuronal activity in the auditory cortex of guinea pig-reconsideration of cross-correlogram method application (2003)

Unit discharges and local field potentials (LFPs) were recorded simultaneously in primary auditory cortex (A1) of a guinea pig for cross-correlograms and cross correlation functions of LFPs were compared. From the results, the adequate periods of signals applied for cross correlation analysis were discussed. Consequently this application period must be selected correspondingly to temporally changing response periods.
Outcomes following administration of tranexamic acid in combat-related intracranial hemorrhage: a cohort study (2020)

Abstract BACKGROUND : Tranexamic acid (TXA) may be a useful adjunct for military patients with severe traumatic brain injury (TBI). These patients are often treated in austere settings without immediate access to neurosurgical intervention. The purpose of this study was to evaluate any association between TXA use and progression of intracranial hemorrhage (ICH), neurologic outcomes, and venous thromboembolism (VTE) in TBI. METHODS : This was a retrospective cohort study of combat casualties from October 2010 to December 2015 who were transferred to a military treatment facility (MTF) in the United States. Data collected included: demographics, types of injuries, initial and interval head computerized tomography (CT) scans, Glasgow Coma Scores (GCS), and six-month Glasgow Outcome Scores (GOS). Results were stratified based on TXA administration, progression of ICH, and VTE. RESULTS : Of the 687 active duty service members reviewed, 71 patients had ICH (10.3%). Most casualties were injured in a blast (80.3%), with 36 patients (50.7%) sustaining a penetrating TBI. Mean ISS was 28.2 ± 12.3. Nine patients (12.7%) received a massive transfusion within 24 hours of injury, and TXA was administered to 14 (19.7%) casualties. Patients that received TXA had lower initial reported GCS (9.2 ± 4.4 vs. 12.5 ± 3.4, p=0.003), similar discharge GCS (13.3 ±4.0 vs. 13.8±3.2, p=0.58), and a larger improvement between initial and discharge GCS (3.7±3.9 vs. 1.3±3.1, p=0.02). However, there was no difference in mortality (7.1% vs. 7.0%, p=1.00), progression of ICH (45.5% vs. 14.7%, p=0.09), frequency of cranial decompression (50.0% vs. 42.1%, p=0.76), or mean GOS (3.5±0.9 vs. 3.8±1.0, p=0.13). Patients administered TXA had a higher rate of VTE (35.7% vs. 7.0%, p=0.01). On multivariate analysis, however, TXA was not independently associated with VTE. CONCLUSIONS : Patients that received TXA were associated with an improvement in GCS but not in progression of ICH or GOS. TXA was not independently associated with VTE, although this may be related to a paucity of patients receiving TXA. Decisions about TXA administration in combat casualties with ICH should be considered in the context of the availability of neurosurgical intervention as well as severity of extracranial injuries and need for massive transfusion.
Enantioselective Double C−H Activation of Dihydronaphthalenes (2005)

Dirhodium tetrakis((S)-N-dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4) catalyzed reaction of 1,2-dihydronaphthalenes with an excess of methyl vinyldiazoacetates results in a formal double C−H activation, generating four new stereogenic centers with very high stereoselectivity. The mechanism of the C−H activation is complex, involving a combined C−H activation/Cope rearrangement followed by a retro-Cope rearrangement.
Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions (2018)

At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge emerges. Our understanding of these fascinating viruses thus remains incomplete but it seemed appropriate at this moment to look back and reflect on our progress and most important questions that still puzzle us. It is also essential of being careful about concepts that seem so well established, but could still be better validated using new approaches. I hope that the few reflections presented here will stimulate discussions and maybe attract new investigators into the field of reovirus research. Many other aspects of the viral multiplication cycle would merit our attention. However, I will essentially limit my discussion to these central aspects of the viral cycle that are transcription of viral genes and their phenotypic expression through the host cell translational machinery. The objective here is not to review every aspect but to put more emphasis on important progress and challenges in the field.
Transplantation of dedifferentiation fat cells promotes intervertebral disc regeneration in a rat intervertebral disc degeneration model (2017)

Our group has reported that mature adipocyte-derived dedifferentiated fat (DFAT) cells show multilineage differentiation potential similar to that observed in mesenchymal stem cells. In the present study, we examined whether DFAT cell transplantation could contribute to intervertebral disc regeneration using a rat intervertebral disc degeneration (IDD) model. The IDD was created in Sprague-Dawley rats by puncturing at level of caudal intervertebral disc under fluoroscopy. One week after injury, rat DFAT cells (5 × 10<sup>4</sup>, DFAT group, n = 13) or phosphate-buffered saline (PBS, control group, n = 13) were injected into the intervertebral disc. Percent disc height index (%DHI) was measured every week and histology of injured disc was evaluated at 8 weeks after transplantation. Radiographic analysis revealed that the %DHI in the DFAT group significantly higher than that in the control group at 2-3 weeks after transplantation. Histological analysis revealed that ectopic formation of nucleus pulposus (NP)-like tissue at the outer layer of annulus fibrosus was frequently observed in the DFAT group but not in the control group. Transplantation experiments using green fluorescent protein (GFP)-labeled DFAT cells revealed that the ectopic NP-like tissue was positive for GFP, suggesting direct differentiation of DFAT cells into NP-like cells. In conclusion, DFAT cell transplantation promoted the regeneration of intervertebral disc and improved intervertebral disc height in the rat IDD model. Because adipose tissue is abundant and easily accessible, DFAT cell transplantation may be an attractive therapeutic strategy against IDD.
Factores que influyen en la viabilidad y crecimiento de "Undaria pinnitifida" en cultivo, "fouling", tamaño de plántula y períodos de aclimatación presiembra (1996)

Loss-of-function mutations in parkin are the predominant cause of familial Parkinson's disease. We previously reported that parkin-/- mice exhibit nigrostriatal deficits in the absence of nigral degeneration. Parkin has been shown to function as an E3 ubiquitin ligase. Loss of parkin function, therefore, has been hypothesized to cause nigral degeneration via an aberrant accumulation of its substrates. Here we employed a proteomic approach to determine whether loss of parkin function results in alterations in abundance and/or modification of proteins in the ventral midbrain of parkin-/- mice. Two-dimensional gel electrophoresis followed by mass spectrometry revealed decreased abundance of a number of proteins involved in mitochondrial function or oxidative stress. Consistent with reductions in several subunits of complexes I and IV, functional assays showed reductions in respiratory capacity of striatal mitochondria isolated from parkin-/- mice. Electron microscopic analysis revealed no gross morphological abnormalities in striatal mitochondria of parkin-/- mice. In addition, parkin-/- mice showed a delayed rate of weight gain, suggesting broader metabolic abnormalities. Accompanying these deficits in mitochondrial function, parkin-/- mice also exhibited decreased levels of proteins involved in protection from oxidative stress. Consistent with these findings, parkin-/- mice showed decreased serum antioxidant capacity and increased protein and lipid peroxidation. The combination of proteomic, genetic, and physiological analyses reveal an essential role for parkin in the regulation of mitochondrial function and provide the first direct evidence of mitochondrial dysfunction and oxidative damage in the absence of nigral degeneration in a genetic mouse model of Parkinson's disease.
A Comprehensive Mechanistic Picture of the Isomerizing Alkoxycarbonylation of Plant Oils (2014)

Theoretical studies on the overall catalytic cycle of isomerizing alkoxycarbonylation reveal the steric congestion around the diphosphine coordinated Pd-center as decisive for selectivity and productivity. The energy profile of isomerization is flat with diphosphines of variable steric bulk, but the preference for the formation of the linear Pd-alkyl species is more pronounced with sterically demanding diphosphines. CO insertion is feasible and reversible for all Pd-alkyl species studied and only little affected by the diphosphine. The overall rate-limiting step associated with the highest energetic barrier is methanolysis of the Pd-acyl species. Considering methanolysis of the linear Pd-acyl species, whose energetic barrier is lowest within all the Pd-acyl species studied, the barrier is calculated to be lower for more congesting diphosphines. Calculations indicate that energy differences of methanolysis of the linear versus branched Pd-acyls are more pronounced for more bulky diphosphines, due to involvement of different numbers of methanol molecules in the transition state. Experimental studies under pressure reactor conditions showed a faster conversion of shorter chain olefin substrates, but virtually no effect of the double bond position within the substrate. Compared to higher olefins, ethylene carbonylation under identical conditions is much faster, likely due not just to the occurrence of reactive linear acyls exclusively but also to an intrinsically favorable insertion reactivity of the olefin. The alcoholysis reaction is slowed down for higher alcohols, evidenced by pressure reactor and NMR studies. Multiple unsaturated fatty acids were observed to form a terminal Pd-allyl species upon reaction with the catalytically active Pd-hydride species. This process and further carbonylation are slow compared to isomerizing methoxycarbonylation of monounsaturated fatty acids, but selective.
Self-consistent relativistic full-potential Korringa-Kohn-Rostoker total-energy method and applications (1996)

The self-consistent full-potential total-energy Korringa-Kohn-Rostoker electronic-structure method is generalized to include all relativistic effects. The Dirac equation for a general anisotropic 4\ifmmode\times\else\texttimes\fi{}4 potential is solved inside Voronoi polyhedra surrounding each basis atom. As an illustration, the method is used to calculate the self-consistent electronic band structure, the Fermi surface, the equilibrium lattice constant and the bulk modulus of the fcc transition metals Pd, Ir, Pt, and Au. If the cutoff of the multipole expansions of the wave functions is at least ${\mathit{l}}_{\mathrm{max}}$=4, the calculated equilibrium lattice constants of the transition metals deviate from experiment by less than 1%, and the calculated bulk moduli deviate between 6% and 20%, which is comparable to results of other local-density calculations. In addition, the method is used to calculate the self-consistent electronic band structure of the semiconductors GaAs, InSb, and InN, and the equilibrium lattice constant and the bulk modulus of InSb. We find that the inclusion of both spin-orbit coupling and full-potential effects influences the size of the valence-band-width and the band gap in comparison with scalar relativistic local-density calculations. Interestingly, if after self-consistency has been achieved in scalar relativistic calculations, spin-orbit coupling is taken into account by the so-called second variation, the energy bands are found to agree very well with the results obtained here with the full relativistic treatment. \textcopyright{} 1996 The American Physical Society.
Optical Differential-Phase-Shift-Keying Demodulation Using a Silicon Microring Resonator (2009)

We have for the first time experimentally demonstrated an ultrasmall, low power penalty, and robust 10 - Gb/s differential-phase-shift-keying demodulator using a silicon-based microring resonator. The microring resonator is compatible with a wide range of signal bit rates. In optical transmission measurements with 11.6-km nonzero dispersion-shifted fiber, the microring resonator demodulator had comparative power penalty compared with a Mach-Zehnder delay interferometer both in single ended detection. Error-free detection was achieved.
Vestibular Evoked Myogenic Potentials in Newborns (2006)

This study presents a novel method for recording vestibular evoked myogenic potential (VEMP) in newborns, used to investigate the maturation of sacculocollic reflex at birth. Twenty full-term newborns aged 2-5 days old were enrolled in this study. During natural sleep, each newborn underwent distortion product otoacoustic emission test, and VEMP test using the head rotation method. For comparison, 20 healthy adults also underwent VEMP test using the same method. Based on adult criteria, 40 newborn ears revealed normal VEMPs in 40%, prolonged VEMPs in 35%, and absent VEMPs in 25%, indicating that great variation exists in the maturation of the sacculocollic reflex at birth. Comparison of VEMP characteristics between healthy newborns and adults revealed nonsignificant difference in the response rate and the latency of n23. However, significant differences existed in the latency of p13, interpeak p13-n23 interval and p13-n23 amplitude between newborns and adults. In conclusion, VEMPs in newborns can be easily recorded by the head rotation method. Prolonged or absent VEMPs in newborns may reflect incomplete maturity of the sacculocollic reflex pathway, especially the myelination. A further large number of newborns receiving MRI scan for other reasons may undergo VEMP test to verify this hypothesis.
Disclosing verifiable partial information of signed CDA documents using generalized redactable signatures (2009)

Digital signatures are an invaluable tool to provide a means for verifying the integrity and authenticity of digital medical documents. Since these documents may be used by several parties in medical treatment processes, the aforementioned properties are essential. However, the general principle of digital signatures is all or nothing. This means, that given a digital signature it is only possible to verify whether it is valid for the entire document or not. Nevertheless, often there is a necessity that only a part of a already signed medical document is relevant in a subsequent process, e.g. in case of second opinions. Another scenario is the anonymization of medical documents for clinical studies, where the holder of a document solely wants to disclose parts of the document, i.e. for privacy reasons. Consequently, the original signature cannot be used to verify the integrity and authenticity of the ?redacted? document anymore. Hence, the receiver of this redacted document needs to fully trust the content of the document. In this paper we propose a novel concept to solve the aforementioned problem. It is based on so called redactable signatures, which were recently introduced, and allow parties to remove certain parts of a document while preserving the property of verifiability. However, when dealing with documents based on the clinical document architecture (CDA), all existing redactable signatures fail to be really practical. To overcome the problems and shortcomings of existing redactable signatures we propose a novel concept of generalized redactable signatures which is especially applicable for structured documents, e.g. XML documents. Additionally, we will show that our solution can be used to sign partial information of CDA documents, which cannot be realized efficiently with existing solutions (e.g. XML signatures), when the redacted information can be chosen arbitrarily. Finally, the proposed concept provides a solution to an unsolved problem in context of secure eHealth architectures that are based on anonymization.
Image Stitching With Manifold Optimization (2022)

Image stitching usually relies on spatial transformations to perform the overlap alignment and distortion mitigation. This paper presents a manifold optimization method to seek these transformations. The purpose is not to present a new formulation of image stitching, as the proposed method uses common transformations such as homography to align feature correspondences in the overlap and similarity transformations to preserve the shape. Instead, the proposed method is based on a new treatment of these transformations as elements of a prescribed matrix manifold. Its advantage lies in its more effective and efficient optimization in the manifold domain. Specifically, spatially varying homographies are computed by an efficient second-order minimization (ESM) of the geometric error of aligning feature correspondences, but with their intrinsic manifold parameterization. To mitigate the distortion, the interpolation between homography and similarity transformation is performed on a general matrix manifold. These on-manifold operations improve the stitching quality with fewer ghosting and distortion artifacts. The experiments show our manifold optimization for image stitching outperforms other methods.
Catalyse de transformation des oléfines par les complexes du tungstène. II. Télomérisation des oléfines cycliques en présence d'oléfines acycliques (1971)

Abstract La co‐réaction des oléfines cycliques avec les oléfines acycliques en présence des systèmes WOCl 4 /Al(C 2 H 5 ) 2 Cl et WOCl 4 /Sn(C 4 H 9 ) 4 conduit à une télomérisation de l'oléfine cyclique; aux extrémités des molécules de télomère sont fixés deux groupements, identiques ou différents, issus de l'oléfine acyclique par une réaction non consécutive. Ont été plus particulièrement étudiés: le cyclopentène et le cyclooctène d'une part, le pentène‐2, le pentène‐1, le butène‐2 et le propylène d'autre part. Le cyclooctadiène‐1.5 et le cyclododécatriène‐1.5.9 réagissent avec le pentène‐2, par réaction non consécutive, en tant que reste CHCH 2 CH 2 CH. La répartition des télomères obéit à une loi statistique. On propose un schéma réactionnel en accord avec les faits observés dans la réaction de disproportion des oléfines acycliques, la polymérisation des oléfines cycliques et la télomérisation des oléfines cycliques par les oléfines acycliques.
The use of mesenchymal stromal cells improves wound repair in rat abdominal incisions (2012)

More than 200,000 abdominal hernias are repaired each year. Although new surgical techniques and technologies have attempted to combat the occurrence of hernias, patients continue to suffer from hernias following abdominal surgeries. Regenerative therapy, including the use of bone marrow derived‐mesenchymal stromal cells (MSCs), offers a new avenue to reducing the problem of hernias seen in post‐operative patients. Midline laparotomies were performed on three groups of Lewis rats. Group 1 rats were designated as the control group and were repaired without additives. CollaTape containing platelet‐rich plasma (PRP) was used to repair the abdominal incisions of group 2 rats. The incisions of group 3 rats were repaired similarly to group 2 but with the addition of MSCs. At 4 and 8 weeks postoperative, abdominal fascia was excised (n=7 per group). Collagen deposition and organization (as determined by a Trichrome stain) was rated by blinded observers. Group 3 showed significantly increased neovascularization and collagen deposition compared to the abdominal fascia of groups 1 and 2. The results of this study suggest that the use of MSCs in abdominal repairs could serve as a beneficial tool to improve wound healing. Grant Funding Source : LifeCell Hernia Resident/Fellow Research Grant