gebhart/patrepeval huggingface dataset:
Enceladus: Cassini observations and implications for the search for life (2006)

Aims.The recent Cassini discovery of water vapor plumes ejected from the south pole of the Saturnian satellite, Enceladus, presents a unique window of opportunity for the detection of extant life in our solar system.
Effect of Cement Kiln Dust and Rock Dust as Mineral Fillers on Bulk Specific Gravity of Fine Aggregates (2011)

Abstract The bulk specific gravity (Gsb) of aggregates is a critical parameter in the design of asphalt mixes. In the Superpave volumetric mix design, Gsb is used to determine the amount of asphalt binder absorbed by aggregates and the percentage of voids in the mineral aggregate. Problems with the current test methods of measuring the Gsb of fine aggregates, i.e., AASHTO T84 or ASTM C128, have been reported in some previous studies as well as in the current study. These standard test methods remain questionable under certain conditions: (1) When rough and angular as well as small and varying particle size distributions of fine aggregates are present and (2) when water reactive mineral fillers (passing No. 200 sieve) are added to fine aggregates. This study examined the addition of two selected mineral fillers, namely, Cement Kiln Dust (CKD) and rock dust, on the overall Gsb of fine aggregates by employing the AASHTO T84 and the CoreLok-Aggplus test procedures. When using the AASHTO T84 test method, the overall Gsb values reduce for both the additives. When using a newly developed CoreLok method, the Gsb values increased for rock dust up to 10 %, beyond which a reduction is observed. With CKD, the Gsb values show an increase for up to 6 % addition of it and then a decrease is observed. The data suggest that the AASHTO T84 test method may not be applicable in the presence of CKD due to the chemical reactions in the presence of water and the formation of cementitious products. A possibility of chemical reaction due to the presence of limestone in the rock dust and its fine gradation influence the results of the AASHTO T84 test method. Thus, use of the CoreLok method appears more appropriate in the presence of such reactive materials. To further analyze the problem, the specific surface area of fine aggregates and mineral fillers was measured using water vapor and nitrogen adsorption methods. This study also reveals that angular fine aggregates with a high angularity and rough surface texture pose significant difficulty in measuring Gsb by the AASHTO T84 test method.
The unintentional consequences of science teaching (1973)

Abstract In this study the possibility that variations in the nature and extent to which individual students interact with the teacher may, in fact, produce unintentional consequences is examined. A battery of tests measuring pupil cognitive, motivational, and personality characteristics was administered to 150 students in four classes prior to instruction. The nature and frequency of each student's interaction in a sample of five lessons was then determined. Canonical analysis was used to determine how these antecedent pupil characteristics and communication pattern variables were related to science achievement, attitudes towards science and socio‐metric measures. Four independent relationships were found and appear to represent “syndromes” some of which lead to undesirable consequences if allowed to run their full course.
Gradient Counterflow Electrophoresis Methods for Bioanalysis (2010)

CE has evolved as one of the most efficient separation techniques for a wide range of analytes, from small molecules to large proteins. Modern microdevices facilitate integration of multiple sample-handling steps, from preparation to separation and detection, and often rely on CE for separations. However, CE frequently requires complex geometries for performing sample injections and maintaining zone profiles across long separation lengths in microdevices. Two novel methods for performing electrophoretic separations, gradient elution moving boundary electrophoresis (GEMBE) and gradient elution isotachophoresis (GEITP), have been developed to simplify microcolumn operations. Both techniques use variable hydrodynamic counterflow and continuous sample injection to perform analyses in short, simple microcolumns. These properties result in instruments and microdevices that have minimal 'real-world' interfaces and reduced footprints. Additionally, GEITP is a rapid enrichment technique that addresses sensitivity issues in CE and microchips.
Prevalencia de caries en la primera dentinción en alumnos del primer año del Jardín de Niños, María L. Zenteno Zenteno, de la ciudad de San Cristóbal de las Casas, Chiapas (2018)

Director: Mtro. Alberto Ballinas Solis, Dr. Angel Gutierrez Zavala, Mtro. Arturo Mejia Gutierrez
Phase drift cancellation of remote radio frequency transfer using an optoelectronic delay-locked loop (2011)

In this Letter, we propose a phase drift cancellation method for remote radio frequency transfer. Phase fluctuation along the transmission fiber, which is induced by temperature and pressure changes, is measured and compensated by a heterodyne optoelectronic delay-locked loop. The control loop consists of a heterodyne optoelectronic phase detector, a microwave delay module, and the loop filter. We demonstrate the concept by transmitting a 10 GHz microwave frequency over 50 km single-mode fiber, with subpicosecond jitters measured at the remote end.
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation (2018)

Hydroxylation and fluorination of proline alters the pyrrolidine ring pucker and the trans:cis amide bond ratio in a stereochemistry-dependent fashion, affecting molecular recognition of proline-containing molecules by biological systems. While hydroxyprolines and fluoroprolines are common motifs in medicinal and biological chemistry, the synthesis and molecular properties of prolines containing both modifications, i.e., fluoro-hydroxyprolines, have not been described. Here we present a practical and facile synthesis of all four diastereoisomers of 3-fluoro-4-hydroxyprolines (F-Hyps), starting from readily available 4-oxo-l-proline derivatives. Small-molecule X-ray crystallography, NMR spectroscopy, and quantum mechanical calculations are consistent with fluorination at C<sup>3</sup> having negligible effects on the hydrogen bond donor capacity of the C<sup>4</sup> hydroxyl, but inverting the natural preference of Hyp from C<sup>4</sup>-exo to C<sup>4</sup>-endo pucker. In spite of this, F-Hyps still bind to the von Hippel-Lindau (VHL) E3 ligase, which naturally recognizes C<sup>4</sup>-exo Hyp in a stereoselective fashion. Co-crystal structures and electrostatic potential calculations support and rationalize the observed preferential recognition for (3 R,4 S)-F-Hyp over the corresponding (3 S,4 S) epimer by VHL. We show that (3 R,4 S)-F-Hyp provides bioisosteric Hyp substitution in both hypoxia-inducible factor 1 alpha (HIF-1α) substrate peptides and peptidomimetic ligands that form part of PROTAC (proteolysis targeting chimera) conjugates for targeted protein degradation. Despite a weakened affinity, Hyp substitution with (3 S,4 S)-F-Hyp within the PROTAC MZ1 led to Brd4-selective cellular degradation at concentrations >100-fold lower than the binary K<sub>d</sub> for VHL. We anticipate that the disclosed chemistry of 3-fluoro-4-hydroxyprolines and their application as VHL ligands for targeted protein degradation will be of wide interest to medicinal organic chemists, chemical biologists, and drug discoverers alike.
Imaging plasma docosahexaenoic acid (dha) incorporation into the brainin vivo, as a biomarker of brain DHA: Metabolism and neurotransmission (2011)

Docosahexaenoic acid (DHA) is critical for normal brain structure and function, and its brain concentration depends on dietary DHA content and hepatic conversion from its dietary derived n-3 precursor, a-linolenic acid (α-LNA). We developed an in vivo method in rats using quantitative autoradiography to image incorporation into brain of unesterified plasma DHA, and showed that the incorporation rate equals the rate of brain metabolic DHA consumption. Thus, quantitative imaging of DHA incorporation from plasma into brain can be used as a biomarker of brain DHA metabolism and neurotransmission. The method has been extended to humans with the use of positron emission tomography (PET). Furthermore, imaging in unanesthetized rats using DHA incorporation as a biomarker in response to N-methyl-D-aspartate (NMDA) administration confirms that regional DHA signaling is independent of extracellular calcium, and likely mediated by a calcium-independent phospholipase A2 (iPLA2). Studies in mice in which iPLA2-VIA (β) was knocked out confirmed that this enzyme is critical for baseline and muscarinic cholinergic signaling involving DHA.
Ability of Post-endotoxin serum from BCG-infected mice to induce nonspecific resistance and stimulation of granulopoiesis (1983)

Serum from BCG-infected mice obtained 2 h after injection with endotoxin induced elevated levels of colony-stimulating factor and an increase in splenic granulocyte-macrophage progenitor cells in C3H/HeJ mice. The capacity of such serum to stimulate granulopoiesis may be related to its ability to increase nonspecific resistance to lethal irradiation.
The Course of Glaucoma During Pregnancy (2015)

Objective:To better understand the course of glaucoma during pregnancy in women with preexisting disease. Methods: Retrospective case series of 28 eyes of 15 women with glaucoma followed up during pregnancy. Data were analyzed for age, race/ethnicity, medications, glaucoma type, intraocular pressure (IOP), and visual fields before, during, and after pregnancy. Results: In 16 (57.1%) of 28 eyes, IOP was stable during pregnancy,withnoprogressionofvisualfieldloss.In5eyes (17.9%),visualfieldlossprogressedduringpregnancy,while IOP remained stable or increased. In 5 eyes (17.9%), IOP increased during pregnancy, but there was no progression of visual field loss. In 2 eyes (7.1%), data were inconclusive because of medication noncompliance and preexisting severe visual field loss. Glaucoma medications were usedby13of15patientstocontrolglaucomaduringpregnancy.Theclassesofmedicationsusedmostfrequentlywere -blockers, 2-adrenergic agents, cholinergic agents, and topical carbonic anhydrase inhibitors. Conclusions: The course of glaucoma during pregnancyisvariable,andwomenmustbemonitoredclosely duringpregnancy.Medicationsmaybenecessarytocontrol IOP and to prevent vision loss during pregnancy.
Compensation for Process and Temperature Dependency in a CMOS Image Sensor (2019)

This paper analyzes and compensates for process and temperature dependency among a (Complementary Metal Oxide Semiconductor) CMOS image sensor (CIS) array. Both the analysis and compensation are supported with experimental results on the CIS's dark current, dark signal non-uniformity (DSNU), and conversion gain (CG). To model and to compensate for process variations, process sensors based on pixel source follower (SF)'s transconductance <i>g</i><sub>m</sub><sub>,</sub><sub>SF</sub> have been proposed to model and to be compared against the measurement results of SF gain <i>A</i><sub>SF</sub>. In addition, <i>A</i><sub>SF</sub>'s thermal dependency has been analyzed in detail. To provide thermal information required for temperature compensation, six scattered bipolar junction transistor (BJT)-based temperature sensors replace six image pixels inside the array. They are measured to have an untrimmed inaccuracy within ±0.5 ⁰C. Dark signal and CG's thermal dependencies are compensated using the on-chip temperature sensors by at least 79% and 87%, respectively.
Evaluation of hepatoprotective activity of aqueous extracts of leaves ofBasella albain albino rats (2014)

This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P < 0.001. Aqueous leaf extracts of B. alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin.
Mid-IR Optical and Nonlinear Properties of Germanium on Silicon Optical Waveguides (2014)

The influence of Germanium-on-Silicon waveguide geometries on single-mode and multimode operations as well as on zero birefringence conditions has been deeply investigated in the mid infrared spectrum. The design equations to estimate the single mode conditions have been carried out and interpolated by exponential functions. Moreover, the group velocity dispersion and third-order dispersion have been investigated in the range 3-6 μm as a function of various waveguide geometries. Finally, nonlinear properties, for instance the modal Raman gain, have been investigated, comparing with Silicon-on-Insulator waveguides. The set of results identifies accurate guidelines for the design of these optical waveguides for several applications.
Improved screen-bowl centrifuge recovery using polymer injection technology (2006)

The paper reports the improved screen-bowl centrifuge recovery process using polymer injection technology. Field test and economic analysis are also included in the paper. 3 refs., 3 figs., 1 tab.
Macrophages Offer A Paradigm Switch for CNS Delivery of Therapeutic Proteins (2013)

The optimized cross-linked nanozyme loaded into macrophages reduced neuroinflammatory responses and increased neuronal survival in mice. Importantly, the approach for nanoformulation design for cell-mediated delivery is different from the common requirements for injectable formulations.
Amine-Sulfur Dioxide Complexes. Solid-Liquid-Gas Equilibria and Infrared Spectra of Complexes with N,N-Dimethylanilines (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmine-Sulfur Dioxide Complexes. Solid-Liquid-Gas Equilibria and Infrared Spectra of Complexes with N,N-DimethylanilinesWillis E. ByrdCite this: Inorg. Chem. 1962, 1, 4, 762–768Publication Date (Print):November 1, 1962Publication History Published online1 May 2002Published inissue 1 November 1962https://pubs.acs.org/doi/10.1021/ic50004a010https://doi.org/10.1021/ic50004a010research-articleACS PublicationsRequest reuse permissionsArticle Views317Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tunable Nonlinear Viscoelastic “Focusing” in a Microfluidic Device (2007)

In this Letter we describe a novel method for tunable viscoelastic focusing of particles flowing in a microchannel. It is proposed that some elasticity, inherently present in dilute polymer solutions, may be responsible for highly nonuniform spatial distribution of flowing particles across the channel cross section, yielding their "focusing" in the midplane of the channel. A theory based on scaling arguments is presented to explain the lateral migration and is found to be in a very good agreement with the experimental observations. It was found that, in agreement with the theoretical prediction, the particles would have different spatial distribution depending on their size and rheology of the suspending medium. We demonstrate how the viscoelastic focusing can be precisely controlled by proper rheological design of the carrier solution.
Closed-loop design and time-optimal control for a series-capacitor buck converter (2016)

This paper explores the large-signal and smallsignal dynamics of a series-capacitor (SC) buck-type converter and introduces an optimal closed-loop control scheme to accommodate both the steady-state and transient modes. As opposed to a conventional buck converter, where time-optimal control is realized by a single on-off cycle, in the SC-buck topology there is a need to distribute the switching phases to satisfy the charge-balance of the flying capacitor. The new control method hybrids a voltage-mode small-signal controller for steady-state operation and a non-linear, state-plane based transient-mode control scheme for load transients. A detailed principle of operation of the SC-buck converter is provided and explained through an average behavioral model and state-plane analysis. The operation of the controller is experimentally verified on a 12W 12V-to-1.5V converter, demonstrating voltage-mode control operation as well as time-optimal response for load transients.
Dynamical Breaking of Charge Neutrality in Intrinsic Josephson Junctions: Common Origin for Microwave Resonant Absorptions and Multiple-Branch Structures in theI−VCharacteristics (1999)

We demonstrate that both microwave resonant absorptions and multiple-branch structures in the $I\ensuremath{-}V$ characteristics observed in intrinsic Josephson junctions are caused by the dynamical breaking of the charge neutrality inside the atomic-scale superconducting layers. The Lagrangian for the time-dependent Lawrence-Doniach model incorporating the charge neutrality breaking effect is proposed. On the basis of the Lagrangian, the longitudinal collective Josephson plasma mode is proved to exist. The branching behaviors in the $I\ensuremath{-}V$ curves are almost completely reproduced by careful numerical simulations for the model equation derived from the Lagrangian.
How flow cytometry is changing the study of TB immunology and clinical diagnosis (2008)

The application of flow cytometry has hugely advanced the field of tuberculosis (TB) across all areas of research ranging from diagnostic tests to understanding the underlying immunology. As cellular responses are understood to be the mainstay of the immune response in the control of TB it is very likely that polychromatic flow will become the tool of choice for assessing the effects of vaccination. Results are particularly encouraging in this area. The development of a new type of diagnostic test, a prototype of which has been reported, may be the spin-off of a broad and systematic approach to understanding and profiling the T-cell response to TB. It is obvious that flow cytometry will not be able to address all research questions in the field of TB. However, its enormous flexibility as a technology will make it the tool of choice in many situations. An ever increasing availability of flow cytometers, even in resource-poor countries, will rapidly change the face of TB research and management in the years ahead.
Reduction of Cesium Leaching Ratio from Cementitious Resin Forms Using Natural Active Silica. (1992)

Cesium adsorption behavior of active silica, which is a natural acid clay composed of cristobalite and quartz, was evaluated for its applicability as Cs adsorbent to be added to cementitious waste forms containing spent ion exchange resin. Since active silica carried the Cs exchangeable silanol group (—SiOH) originally, the Cs distribution coefficient was remarkably high (<104). It increased in saturated Ca(OH)2 solution, simulating the cement paste, due to formation of new silanol groups. With its addition to the cementitious forms with 134Cs adsorbed ion exchange resin solidified by slag cement, the Cs leaching ratio was reduced to below 1/10 that without active silica.
Charged Fog Technology Part I: Theoretical Background and Instrumentation Development (1983)

Water sprays, the most common method of controlling dust in mines and from fugitive emission sources, do not control inhalable particles very effectively. Since most industrial pollutants and naturally occurring fugitive dust particles acquire electric charges as they are dispersed into the air, the inhalable particle control efficiency of water sprays can be significantly improved if the water droplets are also electrically charged to the opposite polarity. Commercially available charged fog devices have several disadvantages. They require high pressure air and/or water, their nozzles are prone to clogging, and they generate charged droplets which are poorly suited for good inhalable particle control. This paper reviews the basic principles of charged fog technology and describes a new charged fog generator which overcomes the problems of commercial charged fog devices. In the charged fog generator (CFG), water from a reservoir is introduced into a rotating cup where the water forms a thin layer due to centrifugal forces. As the water moves towards the lip of the cup, high speed air from an axial fan strikes the thin water film, breaks it into fine droplets and projects the droplets forward. The droplets thus generated have a typical mass median diameter of about 200 μm and a concentration median diameter of about 100 μm. The droplets are electrically charged by contact charging the inflowing water, providing a typical charge to mass ratio of 1.2 X 10-6 C/g with an applied voltage of about 15 kV. The water flow rate in the CFG can be varied from 4-70 L/h and the spray pattern can be easily adjusted to conform to the size and shape of the dust source to be treated. Other advantages of this device are that it uses only about 1 kW power, it is portable, and it is easily adaptable for use at remote areas where commercial electrical power supply is not available.
Gateway (October 2013) (2013)

Articles: How Will The Government Shut Down Affect College Students? by Marissa Russo;&#13;\nAvoiding the Freshman Fifteen: Fitness and Health by Maria Almonte;&#13;\nFM Holds Transfer Fair by Marissa Russo;&#13;\n79 Million Young Adults Have HPV Sexual Disease by Corina Boehme;&#13;\nClub Fair Goes Up In Smoke by Anthony Auspelmyer;&#13;\n2013 Halloween Movie Reviews by Jordan Lincourt;&#13;\nStudents Elected To Fulmont College Association by Shaunice Harris;&#13;\nTACTConference by Lisa Gandia;&#13;\nTV, Music &amp; Entertainment by Erica Redwood;&#13;\nPure Heronie Review by Ruben;&#13;\nMental Health Counseling Now Offered by Corine Walker;&#13;\nIntramural Sports Delayed by Carlos Rivera;