gebhart/patrepeval huggingface dataset:
Bilateral image subtraction features for multivariate automated classification of breast cancer risk (2014)

Early tumor detection is key in reducing breast cancer deaths and screening mammography is the most widely available method for early detection. However, mammogram interpretation is based on human radiologist, whose radiological skills, experience and workload makes radiological interpretation inconsistent. In an attempt to make mammographic interpretation more consistent, computer aided diagnosis (CADx) systems has been introduced. This paper presents an CADx system aimed to automatically triage normal mammograms form suspicious mammograms. The CADx system co-reregister the left and breast images, then extracts image features from the co-registered mammographic bilateral sets. Finally, an optimal logistic multivariate model is generated by means of an evolutionary search engine. In this study, 440 subjects form the DDSM public data sets were used: 44 normal mammograms, 201 malignant mass mammograms, and 195 mammograms with malignant calci cations. The results showed a cross validation accuracy of 0.88 and an area under receiver operating characteristic (AUC) of 0.89 for the calci cations vs. normal mammograms. The optimal mass vs. normal mammograms model obtained an accuracy of 0.85 and an AUC of 0.88.
Moire fringe reduction by optical filters in integral three-dimensional imaging on a color flat-panel display (2005)

We propose a method to reduce the color moire fringes that are attributable to the structure of a color flat-panel display in integral three-dimensional imaging. The method uses two types of optical low-pass filter, diffuser and defocus. The effectiveness of the method was confirmed in an experiment. We describe a way to design these filters with moire's residual energy and video signal energy as indices and demonstrate the validity of the model, which combines two filters to reduce moire fringes.
Serge Nikitine (1987)

35°K in 4 hours at a fraction of the cost of conventionaly pumped systems.• Variable temperatures from .35°K to 300°K Also available-4
Jamun Seed: A Review on Bioactive Constituents, Nutritional Value and Health Benefits (2022)

Jamun fruit, a member of the Myrtaceae family, is commercially grown in tropical and subtropical areas of the world for its fruits with sweet, sour, and astringent luscious flesh. Seeds of jamun fruits are discarded as trash during the industrial processing of fruit pulp into beverages, jellies, jam, vinegar, wine, and squash. These seeds are a potential source of bioactive compounds including hydrolysable tannins, phenolic acids, flavonoids, other phenolics, terpenoids, phloroglucinol derivatives and saponins, which have been endorsed several biological activities, such as antidiabetic, anticancer, anti-inflammatory, antioxidant, antimicrobial, antihyperlipidemic and antihypercholesterolemic, as well as cardioprotective, hepatoprotective and neuroprotective properties. High contents of carbohydrates, dietary fiber, minerals, and ascorbic acid have also been found in jamun seeds. However, potential utilization of these seeds as innovative implements for health benefits has not yet been fully understood. We aim to compile scientific research and recent advances on jamun seed nutritional profile, bioactive compounds composition, bioactive properties, and their potential as an ingredient in functional food formulation.
Flashover voltage of epoxy-resin surfaces in carbonized transformer oil (2002)

This paper reports on experimental investigations dealing with the influence of carbon particles on the flashover voltage of the interface between epoxy resin rods and mineral based transformer oil in a homogeneous as well as in an inhomogeneous electrode configuration. The obtained results reveal that In an uniform field the flashover voltage under carbonized oil for long gap distances is slightly higher than under new oil. In case of a non-uniform electrode arrangement an increase of the carbon content is combined with a significant improvement of the breakdown and the flashover voltage.
Supplementary Methods, Figures 1 - 8 from Selenium Suppresses Leukemia through the Action of Endogenous Eicosanoids (2023)

&lt;p&gt;PDF file - 772KB, Supplementary Figure 1. Selenium supplementation abrogates leukemia in a Friend leukemia (FVP) model. Supplementary Figure 2. Effect of selenium supplementation on the splenic histopathology in FVP-infected mice. Supplementary Figure 3. Selenium supplementation increases apoptosis in the spleen of FVP infected mice.Supplementary Figure 4. Essential role of the COX/eicosanoid pathway in the ablation of LSCs in FVP-infected Se-S mice. Supplementary Figure 5. Modulation of expression of NADPH oxidases (A) and Gpx4 (B) by selenium-treatment of BCR-ABL+LSCs. Supplementary Figure 6. Expression of Tp53, Cat and Sod2 in the spleen of FVP-infected mice. Supplementary Figure 7. Activation of p53 in FVP-infected Se-S and MSA mice. Supplementary Figure 8. Selenium-dependent expression of selenoproteins and CyPG synthesis machinery and endogenous production of 12-PGJ2 by LC-MS/MS in BCRABL+ LSCs.&lt;/p&gt;
On-demand loop-free routing with link vectors (2004)

We present the on-demand link vector (OLIVE) protocol, a routing protocol for ad-hoc networks based on link-state information that is free of routing loops and supports destination-based packet forwarding. Routers exchange routing information reactively for each destination in the form of complete paths, and each node creates a labeled source graph based on the paths advertised by its neighbors. A node originates a broadcast route request to obtain a route for a destination for which a complete path does not exist in its source graph. When the original path breaks, a node can select an alternative path based on information reported by neighbors, and a node can send a unicast route request to verify that the route is still active. A node that cannot find any alternate path to a destination sends route errors reliably to those neighbors that were using it as next hop to the destination. Using simulation experiments in ns2, OLIVE is shown to outperform DSR, AODV, OLSR and TBRPF, in terms of control overhead, throughput, and average network delay, while maintaining loop-free routing with no need for source routes.
Cross-tier interference mitigation considering pilot overhead for TDD MIMO heterogeneous networks (2020)

In a two-tier heterogeneous network, cross-tier interference mitigation between macro-cell (MC) and small-cell (SC) is an important issue, where MC and SC share the same time/frequency resources. In this article, we propose a method to mitigate downlink cross-tier interference between MC and SC, where macro-cell base-station (MBS) and small-cell base-stations have multiple antenna arrays and their precoding weights are optimized to mitigate mutual cross-tier interference under a given pilot overhead. Simulation results show that the proposed scheme improves the downlink sum-rate compared with conventional scheme that coordinates cross-tier interference from MBS to small-cell users under the same pilot overhead condition.
A new ‘aging males’ symptoms' rating scale (1999)

Unlike in women, where instruments are available to measure the severity of symptoms, standardized instruments are lacking for aging males. However, a new ‘aging males’ symptoms' (AMS) rating scale has been developed in the present study, as well as reference values.A total of 116 medically well-characterized males (aged over 40 years) were recruited to complete a questionnaire of symptoms, the prevalence of which commonly changes with increasing age. Factor analysis was used to establish the raw scale and to identify the dimensions of the scale. This raw scale was applied to a large representative population sample of 992 German males, to establish reference values for the severity of symptoms in males over 40 years.Three dimensions of symptoms were identified in the patient group: a psychological, a somatovegetative and a sexual factor, that explained 51.6% of the total variance. Reference values of the three dimensions were defined to be used in daily practice. The severity of symptoms assessed using the AMS scale was found to be related to the clinically defined ‘male climacteric’ in the patient group.The AMS scale is a new and valuable tool for assessing aging males' symptomsc and can be easily used in practice.
Optimization of phase-locked loop performance in data recovery systems (1994)

Optimized design conditions are presented for a phase-locked loop (PLL) used as a functional block in data recovery systems with the primary function of timing recovery. A mathematical model is presented which takes into account the nonlinear and discrete-time nature of the PLL when used in data recovery applications. Performance attributes for these systems such as acquisition, tracking, and noise are considered. A systematic design procedure is presented which permits quantitative trade-offs among these performance attributes. The validation of the mathematical model and the systematic design procedure on a practical circuit implementation in CMOS technology is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization (1991)

The expression of a major cellular substrate for protein kinase C, the MARCKS protein, is regulated in a cell-, tissue-, and developmental stage-specific fashion; in addition, this expression can be stimulated acutely by various cytokines in certain cell types. We have begun to characterize the human gene in order to elucidate the genetic elements responsible for this highly regulated expression. We first cloned a human MARCKS cDNA, which encoded a predicted protein of 332 amino acids (Mr 31,600) that was approximately 89, 74, and 59% identical to the bovine, mouse, and chicken proteins, respectively. Regions conserved at the amino acid level included the amino-terminal myristoylation consensus sequence, the site of intron splicing, and the phosphorylation site domain. The human cDNA was used to demonstrate that tumor necrosis factor-alpha could rapidly stimulate MARCKS gene transcription in the human promyelocytic leukemia cell line HL60. Genomic clones were then isolated; sequence analysis identified a putative promoter region that had no TATA box and contained multiple transcription initiation sites in a region spanning 57 base pairs (bp). This was followed by a 5'-untranslated region of approximately 400 bp, which displayed a complex predicted secondary structure with a delta G of -73.4 kcal/mol. Plasmid constructions containing between 52 and 1453 bp of the human MARCKS promoter linked to the human growth hormone gene were then used in transient expression experiments. Constructions containing 52 and 110 bp of the MARCKS promoter did not exhibit promoter function while the larger constructions all exhibited promotor function; the 248-bp fragment of the MARCKS promoter was 80% as effective as the human ferritin promoter in stimulating expression of human growth hormone in intact cells. Using an insert from the human genomic clone as a probe, we identified human chromosome 6, q21-qter, as the location of the MARCKS gene; this has been assigned the gene symbol MACS.
Digital Position Control for Analog Servos (2006)

Abstract — RC-servos are widely used to build robots with many degrees of freedom, because they are small, inexpensive, and easy to interface. Their main advantage, though, is their good weight-to-torque ratio. Many robots in the RoboCup Humanoid League, for example, almost entirely consist of servos. RC-servos come in two flavors: analog and digital. In analog servos, the internal controller is synchronized to the pulse train that encodes the target position. A typical problem of analog servos is that they suffer from large position tracking errors and variations of the zero-position which are caused by changes in temperature and/or supply voltage. To overcome these problems, digital servos have been introduced in the last years. Digital servos are, however, about twice as expensive as analog servos. Furthermore, all large servos are still analog. We constructed the legs of a 120cm humanoid robot from large analog servos. To improve position control, we modified the servos by replacing in the internal circuit the potentiometer with two equivalent resistors. The potentiometer is now interfaced to a microcontroller that measures position, implements digital position control, and sends motion commands to the analog servo controller. This approach makes it possible to use more advanced control techniques, compared to the original controller. For example, long-term position errors can be avoided by integrating the short-term error. Similar to other intelligent actuators, the parameters of the controller can be changed on a fast time scale, e.g. depending on the gait phase. Furthermore, the digital actuator is able to generate feedback for higher control levels. As the microcontroller is shared between multiple servos and was already in place prior to the modification, the additional hardware needed is negligible. We evaluate the proposed approach using systematic test signals. The results indicate that position control is more precise, more flexible, and more stable than before. I.
Adaptive precoding in MIMO wireless communication systems using blind channel prediction over frequency selective fading channels (2005)

This paper investigates the feasibility of Tomlinson-Harashima precoding when transmitting over multiple-antenna radio interfaces. In particular, we focus on the robustness of adaptive methods with respect to channel estimation errors. Two approaches are investigated to obtain predictions of the channel impulse response required to select the precoding parameters: Kalman filtering and particle filtering. Kalman filtering exhibits good performance but requires knowledge of the transmitted symbols in advanced. The particle filtering method considered in this work, on the other hand, is a blind technique that provides higher spectral efficiencies with a small loss in performance
Managing Procurements in the Time of Covid-19: SNS-PPU as a Case Study (2022)

In early 2020, COVID-19 swept across the world. The accelerator industry, like many others, was impacted by disease, delays, shortages, and new working conditions. All Thomas Jefferson National Accelerator Facility (JLab) employees were sent home in mid-March 2020, with many still working remotely now. At the time, JLab was working on the Proton Power Upgrade (PPU) to the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL). Procurements had been placed and were being managed, parts were being received and inspected. This paper details the JLab procurement plan for the SNS PPU project, and the mitigations that were developed to continue to support this project smoothly under the limitations imposed by COVID-19.
Structure, viability and bacterial kinetics of an in vitro biofilm model using six bacteria from the subgingival microbiota (2011)

An in vitro biofilm model was developed and validated, demonstrating a pattern of bacterial colonization and maturation similar to the in vivo development of the subgingival biofilm.
Appearance analysis for diagnosing malignant lung nodules (2010)

An alternative method of diagnosing malignant lung nodules by their visual appearance rather than conventional growth rate is proposed. Spatial distribution of image intensities (or Hounsfield values) comprising the malignant nodule appearance is accurately modeled with a rotation invariant second-order Markov-Gibbs random field. Its neighborhood system and potentials are analytically learned from a training set of nodule images with normalized intensity ranges. Preliminary experiments on 109 lung nodules (51 malignant and 58 benign ones) resulted in the 96.3% correct classification (for the 95% confidence interval), showing the proposed method is a promising supplement to current technologies for early diagnostics of lung cancer.
From Isocyanides to Trichloropyruvamides: Application to a New Preparation of Oxamide Derivatives. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The design of an intelligent monitoring system for human hand behaviors (2020)

Intelligent monitoring to observe human behaviors and report anomaly activities is a common application of computer vision technologies. However, to the authors knowledge, there has not been a widely accepted structure of building such a system with the fast-developing deep learning method. Within the author's knowledge, current works focus on industrial and traffic conditions, such as measuring the speeds of vehicles in highways, or to help arrange agriculture productions. This paper presents an efficient approach to applying deep learning techniques in such systems to help analyze human behaviors. Specifically, we combined the advancing object detection, pose estimation and image classification methods in our work to recognize some anomaly or special behaviors in determined scenes.
Could HIV-1 RNA Testing be an Option as the Second Step in the HIV Diagnostic Algorithm? (2020)

The APT-Quant has excellent performance for diagnostic use. The 2-test algorithm works well in ART-naive samples, but its performance decreases after the IgG response is elicited and with ART-induced suppressed viremia. Providing confirmation and viral load assay with 1 test result could be advantageous for patient care. However, additional factors and challenges associated with the implementation of this 2-test algorithm, such as cost, specimen type, and collection need further evaluation.
A Reconfigurable 5G Testbed for V2X and Industry4.0 Applications (2017)

Future 5G technologies need to support different types of
use cases, each with different type of requirements. In this
paper, we present a Reconfigurable 5G Testbed Solution used
to support different V2X and Industry 4.0 use cases. Enabling
Cooperative Collision Avoidance for automated driving using
5G technology to improve the road safety. 5G enhanced with
low-latency, high reliability and throughput is one of the
crucial goals fitting the diverse requirements for V2X communications.
5G is also a key enabler for new industry addressing
challenging solutions. We discuss different V2X and industrial
use cases implemented in real field test, using a 5G radio
testbed based on flexible and re-configurable software defined
radio that is designed for cooperative automated driving and
new generation industrial communication. The use cases of
Emergency Brake, Teleoperated Driving and Robot As A
Service are elaborated and tested with the same 5G Testbed.
We present our 5G testbed solution showing system design
and technical enablers that can achieve the most stringent linklevel
communication requirements.We finally present the trials
results.
White lupin has developed a complex strategy to limit microbial degradation of secreted citrate required for phosphate acquisition (2006)

White lupins (Lupinus albus L.) respond to phosphate deficiency by producing special root structures called cluster roots. These cluster roots secrete large amounts of carboxylates into the rhizosphere, mostly citrate and malate, which act as phosphate solubilizers and enable the plant to grow in soils with sparingly available phosphate. The success and efficiency of such a P-acquisition strategy strongly depends on the persistence and stability of the carboxylates in the soil, a parameter that is influenced to a large extent by biodegradation through rhizosphere bacteria and fungi. In this study, we show that white lupin roots use several mechanisms to reduce microbial growth. The abundance of bacteria associated with cluster roots was decreased at the mature state of the cluster roots, where a burst of organic acid excretion and a drastic pH decrease is observed. Excretion of phenolic compounds, mainly isoflavonoids, induced fungal sporulation, indicating that vegetative growth, and thus potential citrate consumption, is reduced. In addition, the activity of two antifungal cell wall-degrading enzymes, chitinase and glucanase, were highest at the stage preceding the citrate excretion. Therefore, our results suggest that white lupin has developed a complex strategy to reduce microbial degradation of the phosphate-solubilizing agents.
Mass Spectrometric Analyses of Brain Synaptic Peptides Containing Taurine (1984)

The structure of a number of low-molecular-weight acidic peptides containing taurine prepared from calf brain synaptosomes and their subcellular vesicles was studied using electron impact mass spectrometry. At least seven sequences could be identified: N-acetylaspartyl-glutamyl-taurine, N-acetylaspartyl-taurine, N-acetylglutamyl-taurine, glutamyl-taurine, aspartyl-taurine, seryl-glutamyl-seryl-taurine, and seryl-taurine.
Presynaptic BDNF Promotes Post-Synaptic Long-Term Potentiation in the Dorsal Striatum - eScholarship (2010)

Brain-Derived Neurotrophic Factor (BDNF) facilitates the formation of long-term potentiation (LTP) in hippocampus but whether this involves release from pre- vs. post- synaptic pools is unclear. We therefore tested if BDNF is essential for LTP in dorsal striatum, a structure in which the neurotrophin is present only in afferent terminals. Whole cell recordings were collected from medium spiny neurons in striatal slices prepared from adult mice. High frequency stimulation (HFS) of neocortical afferents produced a rapid and stable NMDA receptor-dependent potentiation. The ratio of AMPA to NMDA receptor-mediated components of the EPSPs was substantially increased after inducing potentiation, suggesting that potentiation involved post-synaptic changes. In accord with this, paired pulse response ratios, a measure of transmitter release kinetics, were reduced by elevated calcium but not by LTP. Infusion of the BDNF scavenger TrkB-Fc blocked the formation of potentiation, beginning with the second minute post-HFS, without reducing responses to HFS. These results suggest that presynaptic pools of BDNF can act within 2 minutes of HFS to support the formation of a post-synaptic form of LTP in striatum.
Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma (2023)

These results demonstrated that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated EC transcytosis pathway. Our findings identify Wnt signaling as a promising therapeutic target to improve drug delivery for GBM treatment.
The arterial system in pre‐eclampsia and chronic hypertension with superimposed pre‐eclampsia (2005)

The normal gestational changes in systemic arterial mechanical properties are significantly altered in pre-eclampsia and these alterations are more marked with superimposed hypertensive disease.
An Asymmetric Watermarking System With Many Embedding Watermarks Corresponding to One Detection Watermark (2004)

In this letter, we propose a new asymmetric watermarking system which can accommodate many embedding watermarks but needs only one reference watermark for detection. Such a system is useful in averting attacks that seek to estimate the embedding watermark. In the proposed system, the phase of the reference watermark is shifted randomly (clockwise or counterclockwise) in the discrete Fourier transform domain to make embedding watermarks. They are correlated with one another and have the same correlation with the reference one. We also address how to select the design parameters.