gebhart/patrepeval huggingface dataset:
3D vibration measurements by a virtual-stereo-camera system based on a single low frame rate camera (2018)

A 3D full-field optical system for high frequency vibration measurement is proposed. The system is composed of a single low-frame-rate camera and two planar mirrors. This compact optical setup overcomes the typical drawback of capturing synchronous acquisitions in the case of a camera pair. Moreover, planar mirrors allow for the use of the classical pinhole model and, thus, conventional stereo-calibration techniques. The use of a low-frame-rate camera provides on the one hand a high-resolution sensor with a relatively low-cost hardware but imposes, on the other, the adoption of a down-sampling approach, which is applicable only when a single (known) sinusoidal load is applied to the structure. The effectiveness of the proposed setup has been verified by the 3D vibration measurement of two different targets up to a frequency of 1 kHz, corresponding to a displacement amplitude of 0.01 mm.
Active Frequency Tuning for Microresonators by Localized Thermal Stressing Effects (2000)

Active frequency tuning for comb-shape micro resonators has been successfully demonstrated by means of localized stressing effects. A mechanical beam structure that can be resistively heated to generate thermal stress is integrated as part of the micro resonator for frequency tuning. Experimentally, frequency change up to 6.5% is measured for resonators with central frequency around 31kHz. The required tuning power is 25mW in the form of localized joule heating. Analytically, both a one-dimensional electrothermal model and a dynamic model are established to characterize electrical, thermal and frequency responses of active frequency tuning.
STIM1, STIM2, and Orai1 regulate store‐operated calcium entry and purinergic activation of microglia (2014)

Activation of microglia is the first and main immune response to brain injury. Release of the nucleotides ATP, ADP, and UDP from damaged cells regulate microglial migration and phagocytosis via purinergic P2Y receptors. We hypothesized that store-operated Ca(2+) entry (SOCE), the prevalent Ca(2+) influx mechanism in non-excitable cells, is a potent mediator of microglial responses to extracellular nucleotides. Expression analyses of STIM Ca(2+) sensors and Orai Ca(2+) channel subunits, that comprise the molecular machinery of SOCE, showed relevant levels of STIM1, STIM2, and Orai1 in cultured mouse microglia. STIM1 expression and SOCE were down-regulated by treatment of microglia with lipopolysaccharide, suggesting that inflammation limits SOCE by lower STIM1 abundance. Ca(2+) entry induced by cyclopiazonic acid, ATP, the P2Y6 receptor agonist UDP, or the P2Y12 receptor agonist 2-methylthio-ADP (2-MeSADP) was clearly affected in microglia from Stim1(-/-) , Stim2(-/-) , and Orai1(-/-) mice. SOCE blockers or ablation of STIM1, STIM2, or Orai1 severely impaired nucleotide-induced migration and phagocytosis in microglia. Thus, this study assigns SOCE, regulated by STIM1, STIM2, and Orai1 an essential role in purinergic signaling and activation of microglia.
Targeted delivery of reactive species for anticancer therapy (2016)

A promising approach for tumor destruction and eradication of drug-resistant pathogens1 is targeted production of singlet oxygen and other reactive species by photosensitizers (PSs). Excited by visible light, PSs generate singlet oxygen (1O2) and free radicals. Since photo-generated reactive species have short life, damage is limited to structures in close proximity to the PS. Depending on the site and extent of oxidative damage, different cellular responses and mechanisms of cell death are triggered2. Therefore localization of the PS molecule is critical for the outcome of the treatment. Using N-alkylpyridylporphyrins, we determined molecular features that are essential for high photo-efficiency, selectivity and specificity of PSs. Among them are the nature of the coordinated metal, which affects the lifetime of the excited triplet state, and the character of substituents at the periphery of the porphyrin ring. Such substituents introduce charges, modulate lipophilicity3, alter symmetry, and build the overall three-dimensional shape of the molecule4. Each of these features contributes to photodynamic efficiency by affecting singlet oxygen quantum yield, cellular uptake, and subcellular distribution of the PS. Such knowledge is essential for rational design of photoactive and redox-active compounds5 for therapeutic and imaging purposes.
Estimation of Mean Body Temperature from Mean Skin and Core Temperature (2006)

The authors concluded that estimation of MBT from mean skin and core temperatures is generally accurate and precise.
Survey of breast‐feeding practices and outcomes in the cystic fibrosis population (2004)

The aim of this study was to survey cystic fibrosis (CF) patients to determine the frequency of breast-feeding and its association with onset and severity of CF symptoms. Three thousand, two hundred questionnaires were sent to 30 accredited CF centers for anonymous completion. Eight hundred and sixty-three questionnaires were returned and scanned into a database. All results were adjusted for age at time of filling out the questionnaire. Age at onset of symptoms, percent forced expired volume in 1 sec (FEV1%) predicted, and intravenous (IV) antibiotic use were analyzed based on breast-feeding history. Approximately 49% of respondents received human breast milk at some time, but only 18% were exclusively breast-fed. Breast-feeding exclusively for greater than 6 months was associated with a decrease in disease severity based on recent intravenous antibiotic use compared to no breast-feeding (P = 0.03). There was no statistically significant change in onset of symptoms in the setting of breast-feeding; however, a trend toward delayed onset was seen in those receiving human milk. Fifty-three percent of those who breast-fed exclusively > or = 6 months had FEV1% values > 90%, compared to 47% of those not breast-fed. This is a suggestive but not statistically significant difference. In conclusion, breast-feeding for > or = 6 months is associated with decreased use of intravenous antibiotics in the 2 years prior to administering the questionnaire. This survey indicates that breast-feeding is not harmful to children with CF, and may be beneficial.
Investigating the usage of the Chinese wall security policy model for data mining (2005)

Access control requirements for the protection of information/data objects in an information system environment are well defined and successfully implemented by means of access control policies and models. Whenever these objects are used in a data-mining environment, a change in the access control requirements becomes necessary. During a data-mining activity the data miner may expose unexpected results or trends. It is important for all companies involved in data-mining activities to be aware of these potential access control problems.Brewer and Nash (1989) first defined the Chinese Wall Security Policy model (CWSP model). It provides access control for the commercial environment based on conflict of interest classes. Shortly after the introduction of this model, Lin (1989) reported an error in it and presented a modified version called the Aggressive Chinese Wall Security Policy model (ACWSP model). This model introduced the concept of an overlap between conflict of interest classes. It became evident that these two models had the potential to be used in a data-mining environment.
Ultracold matter systems and atomtronics instrumentation. (2011)

Lower limb compartment syndrome is an unusual complication of the genu-pectoral position in lumbar spine surgery. We report a case of compartment syndrome in a patient who was operated in the genu- pectoral position for lumbar schwannoma resection. Overweigth and long time surgery could be important predisposing factors. Early diagnosis and treatment are mandatory to prevent permanent neurological deficits and other possible complications.
Electronic-Controlled Suspension (ECS) (1984)

&lt;div class="htmlview paragraph"&gt;While setting the spring constant and the damping coefficient to small values provide a car with good, soft riding comfort on well-paved roads, it causes poor road-holding characteristics on rough roads and large attitude variations during cornering, acceleration and deceleration. Moreover, it compromises the accident avoidance performance and the high speed directional stability. We have overcome these problems by developing the ELECTRONIC-CONTROLLED SUSPENSION (ECS) which normally responds softly but increases the spring constant and the damping coefficient automatically when running at high speed, cornering, accelerating or decelerating.&lt;/div&gt;
Ordered Submicron Structures in Optical Coatings Obtained by Laser Dewetting of Metallic Thin Film Stacks (2022)

Obtaining large surfaces covered by submicron structures is a challenge in patterning coatings. Using laser induced dewetting, large surface self-assembled ordered metallic structures were used to modify optical properties of interference coatings.
Membrane Fouling in Membrane Bioreactors for Wastewater Treatment (2002)

Membrane bioreactors (MBRs), in which membranes are applied to biological wastewater treatment for biomass separation, provide many advantages over conventional treatment. However, membrane fouling in MBRs restricts their widespread application because it reduces productivity and increases maintenance and operating costs. Recently much research and development has taken place to investigate, model, and control membrane fouling processes. However, unified and well-structured theories on membrane fouling are not currently available because of the complexity of the biomass matrix, which is highly heterogeneous and includes living microorganisms. Membrane fouling in MBR systems can be reversible (i.e., removable by physical washing) or irreversible (removable by chemical cleaning only), and can take place on the membrane surface or into the membrane pores. Although establishing a general model to describe membrane fouling in such a process is made extremely difficult by the inherent heterogeneity of the system, the nature and extent of fouling in MBRs is strongly influenced by three factors: biomass characteristics, operating conditions, and membrane characteristics. Fouling control techniques which have been investigated include low-flux operation, high-shear slug flow aeration in submerged configuration, periodical air or permeate backflushing, intermittent suction operation or addition of powdered activated carbon (PAC). Of these, only PAC addition is currently not used in existing large-scale installations.
PanParser: a Modular Implementation for Efficient Transition-Based Dependency Parsing (2018)

Abstract We present PanParser, a Python framework dedicated to transition-based structured prediction, and notably suitable for dependency parsing. On top of providing an easy way to train state-of-the-art parsers, as empirically validated on UD 2.0, PanParser is especially useful for research purposes: its modular architecture enables to implement most state-of-the-art transition-based methods under the same unified framework (out of which several are already built-in), which facilitates fair benchmarking and allows for an exhaustive exploration of slight variants of those methods. PanParser additionally includes a number of fine-grained evaluation utilities, which have already been successfully leveraged in several past studies, to perform extensive error analysis of monolingual as well as cross-lingual parsing.
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia (1999)

Maternal folic acid supplementation has been suggested to play a role in the prevention of nonsyndromic orofacial clefts, i.e., cleft lip +/- cleft palate. Using a case-control design, we investigated vitamin-dependent homocysteine metabolism in 35 mothers with nonsyndromic orofacial cleft offspring and 56 control mothers with nonmalformed offspring. A standardized oral methionine loading test was performed, in which fasting and afterload plasma total homocysteine, serum and red-cell folate, serum vitamin B12, and whole-blood vitamin B6 levels were determined. We found that both fasting (P < 0.01) as well as afterload (P < 0.05) homocysteine concentrations were significantly higher in cases compared to controls. Hyperhomocysteinemia, defined by a fasting and/or afterload homocysteine concentration above the 97.5th percentile, was present in 15.6% of the cases and in 3.6% of controls (odds ratio, 5.3 (1.1-24.2)). The median concentrations of serum (P < 0. 01) and red-cell (P < 0.05) folate were significantly higher, and vitamin B6 concentrations appeared to be significantly lower (P < 0. 05), in cases compared with controls. No significant difference was observed between groups for vitamin B12. These preliminary data offer evidence that maternal hyperhomocysteinemia may be a risk factor for having nonsyndromic orofacial cleft offspring.
Electrochemical Biosensors for the Determination of Cardiovascular Markers: a Review (2014)

Abstract Nowadays there is a growing interest in the development of devices for the fast and reliable detection and quantification of biomarkers associated with cardiovascular diseases (CVDs). The main objective is not only an early diagnosis of these diseases but also predicting the risk that an individual can suffer CVD. Electrochemical biosensors can play a key role in the development of low cost, portable and rapid sensing platforms for this purpose. This review discusses critically the state of the art in the development, applications and potential suitability of electrochemical biosensors for the determination of cardiovascular biomarkers as well as the required characteristics that these sensors should fulfill to be finally accepted in the clinical community.
In vitro studies of interferon-alpha neurotoxicity (174.14) (2012)

Abstract Elevated levels of interferon-alpha (IFNα) in the CNS is linked to cognitive dysfunction in patients with inflammatory CNS diseases such as HIV-associated dementia. Previous studies showed that IFNα treatment of neuronal cultures caused a dose dependent decrease in dendritic branching and length, mostly prevented after pre-treatment with IFNα neutralizing antibodies. To begin to evaluate the mechanism of decreased dendritic arborization, microtubule associate protein 2 (MAP2), cytoskeleton protein required for dendritic growth and stability in neurons, was looked at. IFNα was found to cause a decrease in total MAP2 protein levels in vitro as soon as 2 hrs after treatment that remained decreased through 48 hrs.. To begin to determine the signaling cascade leading up to effects on MAP2, the cell signaling pathway involving IFNα receptor (IFNAR) was evaluated to show STAT1 phosphorylation, an indicator for JAK-STAT cascade activation, peaks 2 hrs after IFNα stimulation. Both the MAPK/ERK and CREB pathways are being looked at due to their involvement in neuronal growth and STAT1 interaction. IFNα treatment appears to cause an increase ERK activity. The significance of these changese in transcription factor activity is yet to be determined. Our preliminary studies suggest that IFNα is in part acting through its receptor to reduce MAP2 expression in neurons. Determining the mechanism of IFNα neurotoxicity could lead to therapies for cognitive dysfunction during neuroinflammation.
Synthesis of fluorinated phosphonoacetate derivatives of carbocyclic nucleoside monophosphonates and activity as inhibitors of HIV reverse transcriptase (1999)

C. J. Hamilton and S. M. Roberts, J. Chem. Soc., Perkin Trans. 1, 1999, 1051 DOI: 10.1039/A900339H
Efficacy of i-Scan Imaging for the Detection and Diagnosis of Early Gastric Carcinomas (2014)

We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twelve endoscopists (three different skill levels) blinded to patient information evaluated the images. Correlation between demarcation accuracy and lesion brightness on still images was investigated. No significant differences were found in diagnostic accuracy between white light and i-Scan moving images for tumor detection rate (91.7% versus 90.8%, P = 0.777). Diagnostic accuracy of tumor size was comparable between novice and experienced endoscopists for i-Scan moving images (65.7% versus 71.1%, P = 0.528), whereas it was significantly lower for white light moving images (41.2% versus 79.5%, P = 0.019). Tumor demarcation accuracy was significantly better with white light than i-Scan still images (71.0% versus 65.8%, P = 0.033). Correlations between demarcation accuracy and brightness reached highs of 0.75 for white light and 0.89 for i-Scan imaging. Efficacy of i-Scan over that of white light imaging for detecting and diagnosing gastric cancer was not shown; however, the diagnostic capability of i-Scan can be improved if imaging conditions are optimized.
Mineria tecnológica: maneras múltiples para explotar los recursos de la ciencia, tecnología e información (2008)

International audience
A link between frontal white matter integrity and dizziness in cerebral small vessel disease (2022)

One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance.
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci (2019)

Annotating genes based on transcriptomic regulation improves the identification and functional characterization of candidate loci and genes for substance use traits.
Multiphysic Modeling of a High-Speed Interior Permanent-Magnet Synchronous Machine for a Multiobjective Optimal Design (2011)

International audience
Copula-HDP-HMM: Non-parametric Modeling of Temporal Multivariate Data for I/O Efficient Bulk Cache Preloading (2016)

Caching is an important determinant of storage system performance. Bulk cache preloading is the process of preloading large batches of relevant data into cache, minutes or hours in advance of actual requests by the application. We address bulk preloading by analyzing high-level spatio-temporal motifs from raw and noisy I/O traces by aggregating the trace into a temporal sequence of correlated count vectors. Such temporal multivariate data from trace aggregation arise from a diverse set of workloads leading to diverse data distributions with complex spatio-temporal dependencies. Motivated by this, we propose the Copula-HDP-HMM, a new Bayesian non-parametric modeling technique based on Gaussian Copula, suitable for temporal multivariate data with arbitrary marginals, avoiding limiting assumptions on the marginal distributions. We are not aware of prior work on copula based extensions of Bayesian non-parametric modeling algorithms for discrete data. Inference with copulas is hard when data is not continuous. We propose inference based on extended rank likelihood that circumvents specifying marginals, making our inference suitable for count data and even data with a combination of discrete and continuous marginals, enabling the use of Bayesian nonparametric modeling, for several data types, without assumptions on marginals. Finally, we propose HULK, a strategy for I/O efficient bulk cache preloading using our Copula-HDP-HMM model to leverage high-level spatio-temporal motifs in Block I/O traces. In experiments on benchmark traces, we show near perfect hitrate of 0.95 using HULK, a tremendous improvement over baseline using Multivariate Poisson, with only a fourth of I/O overhead.
NEW YORK STATE EDUCATION DEPARTMENT (1966)

A Survey of Registered Professional Nurses Employed in Hospitals in If. Y. State. Albany, N. Y., State Education Department, New York State University.
E PluriBus Unum: High Performance Connectivity On Buses (2008)

Abstract – We present PluriBus, a system that enables high-performance Internet access on-board moving vehicles. It seamlessly bonds multiple wide-area wireless links, which individually tend to be lossy and have high delays, into a reliable communication channel. PluriBus employs a novel technique called opportunistic erasure coding. It sends erasure coded packets only when there is an opening in a path’s spare capacity. Packets are coded using Evolution codes that we have developed to greedily maximize the expected number of packets recovered with each coded packet. These methods let us opportunistically use any spare resources, in a way that minimizes the impact on data traffic. We have deployed PluriBus on two buses. Our experiments show that it reduces the median flow completion time for a realistic workload by a factor of 2.5, compared to an existing method for spreading traffic across multiple paths. 1.
Safety Analysis Results of Representative DEC Accidental Transients for the ALFRED Reactor (2015)

The conceptual design of the Advanced Lead Fast Reactor European Demonstrator (ALFRED) is under development within the LEADER project to meet the safety objectives of Gen IV nuclear energy systems. This paper presents the main results of the safety analysis for beyond design basis conditions, namely design extension conditions (DEC), which include the failure of prevention and mitigation systems, like the reactor scram in the so called unprotected transients. The main objective of this analysis is to evaluate the impact of the core and plant design features on the intrinsic safety behaviour of the ALFRED reactor. Several computer codes: SIM LFR, RELAP5, CATHARE, SPECTRA and TRACE are applied to evaluate the consequences of representative unprotected accident scenarios such as Loss of Flow, Loss of Heat Sink and Reactivity initiated accidents. Additionally, the consequences of steam generator tube rupture and partial sub assembly flow blockage events are assessed by means of appropriate fluid dynamic codes.
Development and Assessment of a Quantitative Reverse Transcription-PCR Assay for Simultaneous Measurement of Four Amplicons (2003)

This is the first study of a quadruplex QRT-PCR assay. Our approach has diagnostic utility in the detection of biomarkers, biological and toxicologic agents, and genes of inherited diseases and cancer.