gebhart/patrepeval huggingface dataset:
Impact of IL-2 on Treatment Tolerance in Patients With High-Risk Neuroblastoma Treated With Dinutuximab Beta-Based Immunotherapy (2020)

Patients with high-risk neuroblastoma treated with continuous long-term infusion of anti-GD2 antibody dinutuximab beta (DB) in combination with IL-2 show an acceptable safety profile. Here, we compared treatment tolerance with and without IL-2. Ninety-nine patients with high-risk neuroblastoma received up to five cycles of DB given as long-term infusion (10 mg/m<sup>2</sup>/d, 100 mg/m<sup>2</sup>; per cycle) with IL-2 (53 patients; regimen A; 6 × 10<sup>6</sup> IU/m<sup>2</sup>/d; 60 × 10<sup>6</sup> IU/m<sup>2</sup>/cycle) and without IL-2 (46 patients; regimen B) in a single-center compassionate use program. Clinical parameters (body temperature, vital signs, Lansky performance score), laboratory values [C-reactive protein, IFN-γ, IL-6, and IL-18 (cycle 1)], and requirement of i.v. co-medication (e.g., morphine, metamizole) were systematically assessed. Patients with stable clinical parameters and that did not require co-medication were defined as potential "outpatient candidates." Patients showed higher levels of body temperature and CRP in regimen A compared to B. However, IL-6 serum concentrations were similar in pts of both cohorts in the first cycle. Patients receiving regimen B showed a shorter time to achieve normal vital parameters and required less co-medication compared to patients in regimen A that resulted in a shorter median time period to discharge and to achieve a potential outpatient status (6d regimen A and 3-5d regimen B after start of antibody infusion, respectively). This study shows that omitting IL-2 from immunotherapy with DB allows reduced co-medication and hospitalization time and therefore results in improved quality of life in patients with high-risk neuroblastoma.
Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III): a single-blind, parallel-group, randomised controlled trial (2021)

National Institute for Health Research (NIHR) Oxford Biomedical Research Centre and NIHR Oxford Health Biomedical Research Centre.
Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin (1996)

1. We compared the ability of rat amylin, rat calcitonin gene-related peptide (CGRP) and rat and salmon calcitonins to elevate cyclic AMP levels and to inhibit [U-14C]-glucose incorporation into glycogen in insulin-stimulated intact rat soleus muscle and in two cell lines derived from rodent skeletal muscle, L6 and C2C12. 2. In intact soleus muscle, both amylin (EC50S of 0.7-6.1 nM) and salmon calcitonin (EC50S of 0.5-1.4 nM) were more potent than CGRP (EC50S of 5.6-15.8 nM) and were much more potent than rat calcitonin (EC50S of 50-137 nM) at stimulating cyclic AMP production, activating glycogen phosphorylase and inhibiting insulin-stimulated [14C]-glycogen formation. 3. In contrast, in both L6 and C2C12 cells, CGRP (EC50S of 0.042-0.12 nM) stimulated cyclic AMP formation and inhibited insulin-stimulated [U-14C]-glucose incorporation into glycogen approximately 1000 times more potently than amylin (EC50S 34-240 nM), while salmon calcitonin was without measurable effect. 4. There was a correlation between elevation of cyclic AMP and inhibition of insulin-stimulated [U-14C]-glucose incorporation into glycogen evoked by these peptides in both intact muscle (r2 = 0.69, P < 0.0004) and muscle cell lines (r2 = 0.96, P < 0.0001). 5. In conclusion, the effects of amylin, CGRP, and calcitonin on soleus muscle glycogen metabolism appear to be mediated by adenylyl cyclase-coupled receptors which show a pharmacological profile similar to high affinity amylin binding sites that have been previously reported in rat brain. In contrast, the effects of amylin and CGRP in L6 and C2C12 rodent muscle cell lines appear to be mediated by adenylyl cyclase-coupled receptors that behave like CGRP receptors.
Learning mid-level motion features for the recognition of body movements (2010)

Robust Recognition of Body Movements based on Critical Mid-Level Features • Humans can recognize body movements (e.g. walking and running) accurately and robustly. • This robustness is demonstrated by the ability of subjects to recognize body movements from strongly impoverished stimuli, like Point-like walkers (PLW), which consist only of a small number of illuminated dots that move like the joints of a human actor [6]. Subjects can even recognize gender, emotions, and identity from these stimuli. • A possible explanation for this robust generalization is that the brain extracts specific motion features (of intermediate complexity) that are shared by both stimuli classes (normal walker and PLW). • The nature of these features is unknown, and it has been discussed whether they are based predominantly on motion or form information [7]. In a recent study, combining methods from image statistics and psychophysical experiments, it was shown that robust recognition can be accomplished based on mid-level motion features [2]. Supported by National Institute of Health grant 2R01-EY-07861-11, Volkswagenstiftung, DFG and HFSP.
Complete amino acid sequence of the precursor region of rat prolactin (1978)

Rat preprolactin was translated in a wheat germ in vitro synthetic system in the presence of 3H-labeled amino acids. The amino-terminal sequence of the radiolabeled precursor was quantitatively identified by high pressure liquid chromatography. The 29 residue precursor sequence is: Met-Asn-Ser-Gln-Val-Ser-Ala-Arg-Lys-Ala-Gly-Thr-Leu-Leu-Leu-Leu-Met-Met-Ser-Asn-Leu-Phe-Cys-Gln-Asn-Val-Gln-Thr-. A discussion of the structure-function relationships of the precursor region and the microsequencing methods used to determine the sequence is presented. The amino-terminal 30 residue sequence of the secreted form of rat prolactin was determined and found to differ at positions 7 and 8 (-Gly-Asp-) from a previously reported rat prolactin sequence (Parlow, A.F., & Shome, B. (1.76) Fed. Proc., Fed. Am. Soc. Exp. Biol. 35, 219).
SnakeFighter - Development of a Water Hydraulic Fire Fighting Snake Robot (2006)

This paper presents the SnakeFighter concept and describes the generic element within this concept in the form of a water hydraulic snake robot. Applications of a SnakeFighter system are presented with focus on fire intervention tasks. The development of a water hydraulic snake robot that demonstrates the concept is described. The robot is the first water hydraulic snake robot ever constructed. The paper identifies design challenges of a complete SnakeFighter system and describes future research on this concept
An Evaluation of the "Back-to-Back" Method of Measuring Adaptor Efficiency (1970)

The problem of adaptor evaluation is of considerable interest in the UHF and microwave art where, because of the several different types of transmission line in common use, there is a frequent need to extend an established measurement capability in one type of line to other types of lines, e.g., from rectangular waveguide to coax. In power and noise calibrations, it is the adaptor efficiency which is usually of interest, and one indication of the adaptor losses may be obtained by connecting an identical pair "back to back" and measuring the insertion loss of the combination by the usual techniques. If, then, the losses are assumed to divide equally between the two, the efficiency is thereby determined. As a practical matter, the losses do not, in general, divide equally, which leads to an error whose evaluation is the subject of this paper. In particular it is shown that the method is capable of good accuracy provided that the assumed identity of the two adaptors is satisfied.
A validated stability‐indicating ultra performance liquid chromatography method for the determination of potential process‐related impurities in eplerenone (2016)

A simple, sensitive, and accurate stability-indicating analytical method has been developed and validated using ultra high performance liquid chromatography. The developed method is used to evaluate the related substances of eplerenone (EP). The degradation behavior of EP under stress conditions was determined, and the major degradants were identified by ultra high performance liquid chromatography with tandem mass spectrometry. The chromatographic conditions were optimized using an impurity-spiked solution, and the samples, generated from forced degradation studies. The resolution of EP, its potential impurities, and its degradation products was performed on a Waters UPLC BEH C18 column (50 × 2.1 mm, 1.7 μm) by linear gradient elution using a mobile phase consisting of 10 mmol/L ammonium acetate adjusted to pH 4.5, methanol and acetonitrile. A photo-diode array detector set at 245 nm was used for detection. The flow rate was set at 0.3 mL/min. The procedure had good specificity, linearity (0.02-3.14 μg/mL), recovery (96.1-103.9%), limit of detection (0.01-0.02 μg/mL), limit of quantitation (0.03-0.05 μg/mL), and robustness. The correction factors of the process-related substances were calculated.
Effects of antidepressant treatment with rTMS and fluoxetine on brain perfusion in PD (2006)

Depression in patients with Parkinson disease is correlated with a dysfunction of the frontal-limbic network that can be modulated by two different antidepressant therapies.
Performance evaluation of modulation and multiple access schemes in ultraviolet optical wireless connections for two atmosphere thickness cases (2016)

The exploitation of optical wireless communication channels in a non-line-of-sight regime is studied for point-to-point and networking configurations considering the use of light-emitting diodes. Two environments with different scattering center densities are considered, assuming operation at 265 nm. The bit error rate performance of both pulsed and multicarrier modulation schemes is examined, using numerical approaches. In the networking scenario, a central node only receives data, one node transmits useful data, and the rest of them act as interferers. The performance of the desirable node&#x2019;s transmissions is evaluated. The access to the medium is controlled by a code division multiple access scheme.
Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus (2001)

Stimulation of the GPi reduces medication side effects, which leads to a better drug tolerance. There was no direct improvement of bradykinesia or tremor by GPi stimulation. Stimulation of the STN ameliorated all parkinsonian symptoms. Daily drug intake was reduced by STN stimulation. The STN is the target of choice for treating patients with severe Parkinson's disease who have side effects from drugs.
Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials (2017)

The first-in-class Bruton's tyrosine kinase inhibitor ibrutinib has proven clinical benefit in B-cell malignancies; however, atrial fibrillation (AF) has been reported in 6-16% of ibrutinib patients. We pooled data from 1505 chronic lymphocytic leukemia and mantle cell lymphoma patients enrolled in four large, randomized, controlled studies to characterize AF with ibrutinib and its management. AF incidence was 6.5% [95% Confidence Interval (CI): 4.8, 8.5] for ibrutinib at 16.6-months <i>versus</i> 1.6% (95%CI: 0.8, 2.8) for comparator and 10.4% (95%CI: 8.4, 12.9) at the 36-month follow up; estimated cumulative incidence: 13.8% (95%CI: 11.2, 16.8). Ibrutinib treatment, prior history of AF and age 65 years or over were independent risk factors for AF. Multiple AF events were more common with ibrutinib (44.9%; comparator, 16.7%) among patients with AF. Most (85.7%) patients with AF did not discontinue ibrutinib, and more than half received common anticoagulant/antiplatelet medications on study. Low-grade bleeds were more frequent with ibrutinib, but serious bleeds were uncommon (ibrutinib, 2.9%; comparator, 2.0%). Although the AF rate among older non-trial patients with comorbidities is likely underestimated by this dataset, these results suggest that AF among clinical trial patients is generally manageable without ibrutinib discontinuation (<i>clinicaltrials.gov identifier: 01578707, 01722487, 01611090, 01646021</i>).
Inverse Designed Plasmonic Metasurface with ppb Optical Hydrogen Detection (2022)

Plasmonic sensors rely on optical resonances in metal nanoparticles and are typically limited by their broad spectral features. This constraint is particularly taxing for optical H2 sensors, in which hydrogen is absorbed inside optically-lossy Pd nanoparticles and for which state-of-the-art detection limits are only at the low parts-per-million (ppm) range. Here, we overcome this limitation by inversely designing a plasmonic metasurface based on a periodic array of Pd nanoparticles. Guided by a particle swarm optimization algorithm, we numerically identify and experimentally demonstrate a sensor with an optimal balance between a narrow spectral linewidth and a large field enhancement inside the nanoparticles, enabling a measured hydrogen detection limit of 250 parts-per-billion (ppb). Our work significantly improves current plasmonic hydrogen sensor capabilities and, in a broader context, highlights the power of inverse design of plasmonic metasurfaces for ultrasensitive (gas) detection.
Profiling the TRB and IGH repertoire of patients with H5N6 Avian Influenza Virus Infection by high-throughput sequencing (2019)

Avian Influenza A (H5N6) Virus causes severe influenza disease in humans and is manifested by acute respiratory distress syndrome, multi-organ failure, and high mortality rates. T cells recognize antigens specifically through a membrane protein T cell receptor (TCR). To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast array of TCRs, which are collectively referred to as the TCR repertoire. The B cell receptor (BCR) is involved in inducing the humoral immune response. The generation of a diverse T cell and B cell repertoire is essential for protection against infection. In this study, multiplex PCR based on genomic DNA amplicons and Illumina high-throughput sequencing (HTS) were applied to study the characteristics and polymorphisms of the TRB and IGH repertoire in the peripheral blood mononuclear cells (PBMCs) from two H5N6 AIV patients and six healthy donors (NC). The CDR3 average length in the AIV group was different from the NC group. The TRBV12-3, TRBV12-4, and TRBV15 gene segments and TRBV30/TRBJ1-2, TRBV12-3/TRBJ1-1 and IGHV3-11/IGHJ6 gene segment pairings also exhibited a higher usage in the PBMCs of AIV donors and may provide more information for generating more effective T/B cell targeted diagnosis/protection strategies.
Allosteric Regulation and Spatial Distribution of Kainate Receptors Bound to Ancillary Proteins (2003)

A diverse range of accessory proteins regulates the behaviour of most ligand- and voltage-gated ion channels. For glutamate receptor 6 (GluR6) kainate receptors, two unrelated proteins, concanavalin-A (Con-A) and postsynaptic density protein 95 (PSD-95), bind to extra- and intracellular domains, respectively, but are reported to exert similar effects on GluR6 desensitization behaviour. We have tested the hypothesis that distinct allosteric binding sites control GluR6 receptors via a common transduction pathway. Rapid agonist application to excised patches revealed that neither Con-A nor PSD-95 affect the onset of desensitization. The rate of desensitization elicited by 10 mM L-glutamate was similar in control (taufast = 5.5 +/- 0.4 ms), Con-A-treated patches (taufast = 6.1 +/- 0.5 ms) and patches containing PSD-95 and GluR6 receptors (taufast = 4.7 +/- 0.6 ms). Likewise, the time course of recovery from GluR6 desensitization was similar in both control and Con-A conditions, whereas PSD-95 accelerated recovery almost twofold. Peak and steady-state (SS) dose-response relationships to glutamate were unchanged by lectin treatment (e.g. control, EC50(SS) = 31 +/- 28 microM vs Con-A, EC50(SS) = 45 +/- 9 microM, n = 6), suggesting that Con-A does not convert non-conducting channels with high agonist affinity into an open conformation. Instead, we demonstrate that the effects of Con-A on macroscopic responses reflect a shift in the relative contribution of different open states of the channel. In contrast, the effect of PSD-95 on recovery behaviour suggests that the association between kainate receptors and cytoskeletal proteins regulates signalling at glutamatergic synapses. Our results show that Con-A and PSD-95 regulate kainate receptors via distinct allosteric mechanisms targeting selective molecular steps in the transduction pathway.
Diagnosis of infectious laryngotracheitis using a monoclonal antibody ELISA (1988)

An ELISA has been developed which uses a selected monoclonal antibody specific for ILT virus. The ELISA proved to be as accurate as, yet faster than, virus isolation, more accurate than the fluorescent antibody test and more accurate and rapid than the relatively simple agar gel precipitin test. The ELISA clearly differentiated between chickens from commercial flocks infected with ILT virus and non-infected chickens, or chickens infected with other respiratory pathogens.
Disappearance of Afterimages at ‘Impossible’ Locations in Space (1984)

An eccentrically positioned afterimage, viewed in the dark, will disappear if the eye is positioned so that the afterimage now projects to a more extreme location relative to straight ahead. It was found that the afterimage disappeared when it projected to a location which corresponded to the edge of the visual field defined by the brow, cheek, and nose. This suggests that visibility of stimuli from those retinal regions shadowed by the head is influenced by eye-position information.
Facile access to amides and hydroxamic acids directly from nitroarenes (2014)

A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid whereas reaction in the presence of 1 mmol acetic acid produced amides as the only product.
N- and O-Glycosylation of a Commercial Bovine Whey Protein Product (2012)

Bovine whey protein products are used as a base ingredient in infant formulas to optimize the amino acid pattern to a more human-like composition. Although the protein composition of bovine milk has been studied in detail, glycosylation details of commercial whey protein products are missing. To this end, both the N- and O-glycans of such a protein concentrate were sequentially released, the N-glycans enzymatically and the O-glycans chemically (reducing and nonreducing conditions). For the structural analysis of the N- and O-glycans a combination of MALDI-TOF-MS, one-dimensional (1)H NMR spectroscopy, Wisteria floribunda agglutinin affinity chromatography, HPAEC-PAD profiling, and HPLC-FD profiling (2-aminobenzamide derivatives), together with exoglycosidase treatments, were used. A mixture of over 60 N-glycans and 10 O-glycans was characterized, giving a detailed insight into the glycosylation of a bovine whey protein product, Deminal 90, which is applied as an ingredient for infant formulas.
Differentiation and ?renewal? of multipotential cells in vitro (1982)

Cells obtained from in vitro colonies expressing multiple hemopoietic lineages (mixed-erythroid colonies) have been shown to produce secondary mixed-erythroid colonies. When individual mixed-erythroid colonies are studied, considerable variation has been observed in the capacity to produce secondary mixed-erythroid colonies. That this heterogeneity in self-renewal capacity may be an intrinsic property of the primary mixed-erythroid colonies has been shown by the ability to fractionate fetal liver mixed-erythroid colony-forming cells with high and low levels of secondary colony formation. In addition mixed-erythroid colony-forming cells obtained from spleens consistently produce higher numbers of secondary mixed-erythroid colonies (up to 250 secondary mixed-erythroid colonies per primary mixed-erythroid colony) than bone marrow-derived mixed-erythroid colonies (no secondary mixed-erythroid colonies obtained) suggesting that external factors may predetermine the ability of primary mixed-erythroid colony-forming cells to self-renew in vitro. The ability of supernatants obtained from long-term marrow cultures to enhance secondary colony formation by bone marrow-derived mixed-erythroid colony-forming cells raises the possibility of defining the nature of the proposed external factors that determine stem cell self-renewal.
Simultaneous scheduling, binding and floorplanning for interconnect power optimization (1999)

Interconnect power dissipation is becoming a major component of power consumption in a circuit especially in sub-micron technologies. The energy dissipated by a particular interconnection link is determined by the switching activity on that link and also on its capacitance. The switching activity is determined by the schedule and binding, whereas the capacitance is determined by the floorplan. Scheduling, binding and floorplanning are closely inter-related. A simultaneous scheduling, binding and floorplanning algorithm is presented which attempts to minimize interconnect energy dissipation. In comparison to a traditional approach which separates high-level synthesis from physical design, our algorithm is able to make these stages interact very closely, resulting in solutions with lower power, latency and area. We show that it is possible to reduce the interconnect energy dissipation by upto around 60 percent for high-level synthesis benchmark circuits.
Corrigendum: The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms (2021)

After the publication of the original article (Kikuchi et al., 2021), the authors noticed that the article contained some errors in the manuscript. The type of specimen to be analyzed in the study was serum, not plasma. Progesterone, estradiol, and testosterone can be measured in either serum or plasma (World Health Organization, 2002). The context of the findings, which is that the delivery of a placenta/fetus with high gonadal steroid production may cause a wider range of fluctuations in maternal gonadal steroid concentrations in the circulation, is not affected after this correction. The authors apologize for any inconvenience this has caused.
A Method for Preparing Codeinone (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Method for Preparing CodeinoneHenry Rapoport and Helen N. ReistCite this: J. Am. Chem. Soc. 1955, 77, 2, 490–491Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01607a086https://doi.org/10.1021/ja01607a086research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts