gebhart/patrepeval huggingface dataset:
[A clinical and pathological report of delayed encephalopathy after heat stroke]. (2021)

<b>Objective:</b> To explore the clinical manifestations, dynamic neuroimaging changes and brain histopathologic characteristics of a patient with delayed encephalopathy after heat stroke. <b>Methods:</b> In October 2019, the clinical manifestations, electroencephalogram, cerebrospinal fluid, imaging changes and brain histopathological characteristics of a patient with brain damage caused by heat stroke were retrospectively analyzed. <b>Results:</b> The patient was a 40-year-old male who suddenly appeared dizziness, unconscious, high fever when working in the high temperature environment. The EEG showed diffuse slow wave activity. Early CT was normal, and abnormal signals gradually appeared in the basal ganglia region of the thalamus after a few days. In the late, the MRI found a large area of abnormal signals under the cerebral cortex, and white matter was involved. Pathological examination of brain biopsy showed that cortical neuron loss, loose white matter changes, and significant demyelination changes, while no inflammatory cell infiltration was observed in subarachnoid space, meninges, and dermal white matter. <b>Conclusion:</b> Imaging examination dynamic changes of the delayed encephalopathy is important in the heat stroke, and the main pathological manifestation is demyelination.
Metrics for rate maximization in multiuser-MISO systems with Zero-Forcing Beamforming (2014)

In this work we present a unified treatment on the most common metrics used in the utility function of state-of-the-art user selection algorithms for sum rate maximization in MISO systems under Zero-Forcing Beamforming. We present the way that such metrics are used to maximize the total sum rate and the relations held among each other. Via simulation we found upper bounds of the average total sum rate for each metric which allow us to establish a benchmark in terms of sum rate performance and a trade-off between the metric accuracy needed to maximize the sum rate and the computational complexity required to determine each metric.
Influence of rapid thermal annealing temperature on the electrical properties of Be-implanted GaAs p-n junctions (1988)

Planar, Be-implanted p-n junctions were fabricated in GaAs with rapid thermal annealing (RTA). Five second isochronal anneals over a temperature range of 600–1000 °C were studied with secondary ion mass spectrometry (SIMS), sheet resistance measurements, and variable diameter p-n junctions. Sheet resistance measurements indicate that a minimum RTA temperature of 600 °C is necessary for electrical activation of the implanted Be. SIMS analysis indicates that significant outdiffusion and surface evaporation of Be occur at all RTA temperatures in this range, while indiffusion of Be is insignificant for concentrations below 1×1018 cm−3. Forward bias current in diodes ranging in diameter from 10 to 1000 μm is dominated by surface recombination, rather than bulk space-charge recombination, over the entire 600–1000 °C temperature range. The magnitude of the surface recombination current is insensitive to the RTA temperature, which suggests that 600 °C RTA should be sufficient for the formation of satisfactory p-n junctions.
Supplementary Fig 4 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Supplementary Fig. 4. p53 pathway is dysregulated in ALL.&lt;/p&gt;
Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis (2000)

The functional 5A/6A polymorphism of the stromelysin-1 promoter has been implicated as a potential genetic marker for the progression of angiographically determined atherosclerosis in patients with coronary artery disease. Recently, a novel interleukin-6 (IL-6) gene functional G/C polymorphism at -174 in the promoter has also been reported. In this study, we analyzed the relation of these two polymorphisms with carotid artery atherosclerosis in 109 randomly selected, middle-aged men without exercise-induced ischemia. Atherosclerosis was quantified as intima-media thickness (IMT) by high-resolution ultrasonography. Univariately, stromelysin genotype was significantly (P:=0.015) associated with IMT, and this relation remained (P:=0.033) after adjustments for age, cardiorespiratory fitness, body mass index, smoking, LDL cholesterol, and systolic blood pressure and for sonographers. The 5A/6A polymorphism independently explained 7% of the variance in carotid bifurcation IMT. The IL-6 polymorphism was also significantly associated (P:=0. 036) with increased IMT, with men homozygous for the G allele having IMT that was 11% greater than men homozygous for the C allele. Men who were homozygous for both the 6A and G alleles had an covariate adjusted IMT that was 36% greater than men who were homozygous for neither allele (P:&lt;0.003). These data suggest that genetic factors that predispose to reduced matrix remodeling (stromelysin 6A allele) and to increased inflammation (IL-6 G allele) combine to increase susceptibility for intima-media thickening in the carotid bifurcation, a predilection site for atherosclerosis.
Limb girdle and facial weakness in female carriers of X-linked myotubular myopathy mutations (2001)

Although X-linked myotubular myopathy (XLMTM) is a recessive disorder, heterozygous female carriers of MTM1 mutations may present with limb girdle and facial weakness. It is proposed that manifesting heterozygote females with XLMTM have a skewed pattern of X-chromosome inactivation. However, skewed X-chromosome inactivation was not detected in either the lymphocyte or muscle DNA of a woman who presented with limb girdle/facial weakness and was found to be heterozygous for the R224X mutation.
Replacement of Stoichiometric DDQ with a Low Potentialo-Quinone Catalyst Enabling Aerobic Dehydrogenation of Tertiary Indolines in Pharmaceutical Intermediates (2019)

A transition-metal/quinone complex, [Ru(phd)<sub>3</sub>]<sup>2+</sup> (phd = 1,10-phenanthroline-5,6-dione), is shown to be effective for aerobic dehydrogenation of 3° indolines to the corresponding indoles. The results show how low potential quinones may be tailored to provide a catalytic alternative to stoichiometric DDQ, due to their ability to mediate efficient substrate dehydrogenation while also being compatible with facile reoxidation by O<sub>2</sub>. The utility of the method is demonstrated in the synthesis of key intermediates to pharmaceutically important molecules.
ChemInform Abstract: Radical Cyclization of O‐Trityl Oximino Esters: A Ring Closure that Preserves the Oxime Function. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A review of supersonic cruise flight path control experience with the YF-12 aircraft (1976)

Flight research with the YF-12 aircraft indicates that solutions to many handling qualities problems of supersonic cruise are at hand. Airframe/propulsion system interactions in the Dutch roll mode can be alleviated by the use of passive filters or additional feedback loops in the propulsion and flight control systems. Mach and altitude excursions due to atmospheric temperature fluctuations can be minimized by the use of a cruise autothrottle. Autopilot instabilities in the altitude hold mode have been traced to angle of attack-sensitive static ports on the compensated nose boom. For the YF-12, the feedback of high-passed pitch rate to the autopilot resolves this problem. Manual flight path control is significantly improved by the use of an inertial rate of climb display in the cockpit.
High gain cavity backed UWB antenna with and without band notch feature (2013)

High directivity antennas are often used in communication systems to meet specific coverage requirements. This paper presents a unidirectional, high gain UWB antenna. A reference UWB antenna is considered and a metallic cavity is built around it, this arrangement along with a stacked parasitic patch shows a maximum increase of 8.5 dB in the gain of the UWB antenna. A maximum increase of 8.43 dB in the gain is seen for the UWB antenna having band rejection feature.
Synthesis and characterization of thin film composite membranes made of PSF-TiO2/GO nanocomposite substrate for forward osmosis applications (2017)

Support layer of thin film composite (TFC) membrane plays an important role in forward osmosis (FO) performance. A new type of support layer or nanocomposite substrate was developed by incorporating titanium dioxide (TiO2)/graphene oxide (GO) into polysulfone (PSF) matrix. Prior to performance evaluation, the developed substrates were characterized with respect to surface chemistry, roughness and cross-sectional morphology. The results showed that both surface hydrophilicity and roughness of PSF-based substrates were increased upon incorporation of nanomaterials. Substrates with long finger-like voids extended from the top to the bottom could be developed upon incorporation of TiO2 (SubstrateTiO2) or TiO2/GO mixture (SubstrateTiO2/GO). The improved surface hydrophilicity and favorable structure formed are the main factors leading to higher water flux of nanocomposite substrate. Moreover, the water flux of FO using TFC membranes could be enhanced using this nanocomposite substrate. Comparing to the control TFC membrane, the TFC membranes made of SubstrateTiO2 and SubstrateTiO2/GO exhibited greater water flux with minimum increase in reverse draw solute flux. Based on the results obtained, it can be concluded that the incorporation of TiO2 and/or GO nanoparticles into PSF substrate could potentially improve the TFC membrane performance during FO applications. Keywords: Nanocomposite substrate, TFC membrane, TiO2, Graphene oxide, Forward osmosis
Whisper: Profile-Guided Branch Misprediction Elimination for Data Center Applications (2022)

Modern data center applications experience frequent branch mispredictions– degrading performance, increasing cost, and reducing energy efficiency in data centers. Even the state-of the-art branch predictor, TAGE-SC-L, suffers from an average branch Mispredictions Per Kilo Instructions (branch-MPKI) of 3.0 (0.5-7.2) for these applications since their large code footprints exhaust TAGE-SC-L’s intended capacity. In this work, we propose Whisper, a novel profile-guided mechanism to avoid branch mispredictions. Whisper investigates the in-production profile of data center applications to identify precise program contexts that lead to branch mispredictions. Corresponding prediction hints are then inserted into code to strategically avoid those mispredictions during program execution. Whisper presents three novel profile-guided techniques: (1) hashed history correlation which efficiently encodes hard-to-predict correlations in branch history using lightweight Boolean formulas, (2) randomized formula testing which selects a locally-optimal Boolean formula from a randomly selected subset of possible formulas to predict a branch, and (3) the extension of Read-Once Monotone Boolean Formulas with Implication and Converse Non-Implication to improve the branch history coverage of these formulas with minimal overhead. We evaluate Whisper on 12 widely-used data center applications and demonstrate that Whisper enables traditional branch predictors to achieve a speedup close to that of an ideal branch predictor. Specifically, Whisper achieves an average speedup of 2.8% (0.4%-4.6%) by reducing 16.8% (1.7%-32.4%) of branch mispredictions over TAGE-SC-L and outperforms the state-of the-art profile-guided branch prediction mechanisms by 7.9% on average.
Generation of ultralow tensions over a wide EACN range using Pennsylvania State University surfactants (1983)

Saturated paraffinic and naphthenic hydrocarbons without aromatics have been vapor-phase oxidized to produce cyclic ethers and lesser amounts of olefins. These cyclic ethers appear to be effective cosurfactants for the preparation of slugs containing petroleum sulfonate surfactants. The cyclic-ether/olefin mixture has been reacted with SO/sub 3/ from oleum or liquid SO/sub 3/ to form sulfonates comprising a mixture of mono-, di-, and polysulfonates. The reaction products consisting of the sulfonates, unreacted oxidized products, and residual hydrocarbons have been extracted with isopropanol (IPA) to give two sulfonate fractions. The first fraction is predominantly monosulfonate with lesser quantities of disulfonates. The second fraction consists primarily of di-, tri-, and polysulfonates. The monosulfonate fraction in a low-concentration slug exhibits ultralow interfacial tension (IFT) against hydrocarbons of low equivalent alkane carbon number (EACN). The behavior of this fraction is similar to that of the commercial sulfonates in that its ability to generate low IFT is confined to a narrow range of EACN. To achieve low IFT's at higher EACN in the range of a Pennsylvania crude oil, it is necessary to raise the equivalent weight of the Pennsylvania State U. monosulfonate fraction by blending with a commercial sulfonate of higher equivalent weight.
Feasibility, Validity, and Reliability of the Italian Pediatric Quality of Life Inventory Multidimensional Fatigue Scale for Adults in Inpatients with Severe Obesity (2018)

The Italian modified PedsQL MFS for adults showed to be a valid and reliable tool for the assessment of fatigue in inpatients with severe obesity. Future studies should assess its discriminant validity as well as its responsiveness to weight reduction.
Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells (2014)

Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor-cell death. The resulting 'immunotoxicity' in the tumor, but not in healthy tissues, may finally lead to immune-mediated destruction of the tumor. However, little is known about the best irradiation scheme in this setting. This study examines the immunological effects of differently irradiated human colorectal tumor cells on human monocyte-derived dendritic cells (DC). Human SW480 tumor cells were irradiated with a norm-fractionation scheme (5 × 2 Gy), a hypo-fractionated protocol (3 × 5 Gy), and with a high single irradiation dose (radiosurgery; 1 × 15 Gy). Subsequently, human immature DC (iDC) were co-incubated with supernatants (SN) of these differently treated tumor cells. Afterwards, DC were analyzed regarding the expression of maturation markers, the release of cytokines, and the potential to stimulate CD4(+) T-cells. The co-incubation of iDC with SN of tumor cells exposed to norm- or hypo-fractionated RT resulted in a significantly increased secretion of the immune activating cytokines IL-12p70, IL-8, IL-6, and TNFα, compared to iDC co-incubated with SN of tumor cells that received a high single irradiation dose or were not irradiated. In addition, DC-maturation markers CD80, CD83, and CD25 were also exclusively elevated after co-incubation with the SN of fractionated irradiated tumor cells. Furthermore, the SN of tumor cells that were irradiated with norm- or hypo-fractionated RT triggered iDC to stimulate CD4(+) T-cells not only in an allogenic, but also in an antigen-specific manner like mature DC. Collectively, these results demonstrate that norm- and hypo-fractionated RT induces a fast human colorectal tumor-cell death with immunogenic potential that can trigger DC maturation and activation in vitro. Such findings may contribute to the improvement of irradiation protocols for the most beneficial induction of anti-tumor immunity.
Classifying Foreground Pixels in Document Images (2009)

We present a system that classifies pixels in a document image according to marking type such as machine print,handwriting, and noise. A segmenter module first splits an input image into fragments, sometimes breaking connected components. Each fragment is then classified by an automatically trained multi-stage classifier that is fast and considers features of the fragment, as well as its neighborhood. Features relevant for discrimination are picked out automatically from among hundreds of measurements. Our system is trainable from example images in which each foreground pixel has a ldquoground-truthrdquo label. The main distinction of our system is the level of accuracy achieved in classifying fragments at sub-connected component level, rather than larger aggregate groups such as words or text-lines.We have trained this system to detect handwriting, machine print text, machine print graphics, and noise.
TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells (2009)

Previous studies in pulmonary arterial smooth muscle cells (PASMCs) showed that the TRPC1 channel mediates capacitative Ca(2+) entry (CCE), but the molecular signal(s) that activate TRPC1 in PASMCs remains unknown. The aim of the present study was to determine if TRPC1 mediates CCE through activation of STIM1 protein in mouse PASMCs. In primary cultured mouse PASMCs loaded with fura-2, cyclopiazonic acid (CPA) caused a transient followed by a sustained rise in intracellular Ca(2+) concentration ([Ca(2+)](i)). The transient but not the sustained rise in [Ca(2+)](i) was partially inhibited by nifedipine. In addition, CPA increased the rate of Mn(2+) quench of fura-2 fluorescence that was inhibited by SKF 96365, Ni(2+), La(3+) and Gd(3+), exhibiting pharmacological properties characteristic of CCE. The nifedipine-insensitive sustained rise in [Ca(2+)](i) and the increase in Mn(2+) quench of fura-2 fluorescence caused by CPA were both inhibited in cells pretreated with antibody raised against an extracellular epitope of TRPC1. Moreover, STIM1 siRNA reduced the rise in [Ca(2+)](i) and Mn(2+) quench of fura-2 fluorescence caused by CPA, whereas overexpression of STIM1 resulted in a marked increase in these responses. RT-PCR revealed TRPC1 and STIM1 mRNAs, and Western blot analysis identified TRPC1 and STIM1 proteins in mouse PASMCs. Furthermore, TRPC1 was found to co-immunoprecipitate with STIM1, and the precipitation level of TRPC1 was increased in cells subjected to store depletion. Taken together, store depletion causes activation of voltage-operated Ca(2+) entry and CCE. These data provide direct evidence that CCE is mediated by TRPC1 channel through activation of STIM1 in mouse PASMCs.
Antibacterial properties of novel Eumelanin-Inspired Phenylene Indolyne derivatives (2020)

BACKGROUND: The eumelanin core represents a novel compound having the intrinsic ability to act as scaffolding for functional groups which may possess antibacterial properties. The purpose of this study was to investigate the antibacterial potential of eumelanin-inspired phenylene indolyne (EIPE) derivatives EIPE-1 and EIPE-HCl which are hydrophobic and hydrophilic, respectively.
FEASIBILITY OF SMARTPHONE BASED PHOTOGRAMMETRIC POINT CLOUDS FOR THE GENERATION OF ACCESSIBILITY MAPS (2018)

Accessible cities with accessible services are an old claim of people with reduced mobility. But this demand is still far away of becoming a reality as lot of work is required to be done yet. First step towards accessible cities is to know about real situation of the cities and its pavement infrastructure. Detailed maps or databases on street slopes, access to sidewalks, mobility in public parks and gardens, etc. are required. In this paper, we propose to use smartphone based photogrammetric point clouds, as a starting point to create accessible maps or databases. This paper analyses the performance of these point clouds and the complexity of the image acquisition procedure required to obtain them. The paper proves, through two test cases, that smartphone technology is an economical and feasible solution to get the required information, which is quite often seek by city planners to generate accessible maps. The proposed approach paves the way to generate, in a near term, accessibility maps through the use of point clouds derived from crowdsourced smartphone imagery.
Auditory Imperception (1976)

The diagnosis, evaluation and treatment of learning disabilities involves many disciplines. The Otolaryngologist can play an important role in reducing the psychosocial-educational effects of perceptual hanicaps by being active in early diagnosis. This paper presents: 1) an overview of significant information pertaining to auditory perceptual problems and 2) suggestions for the clinican interested in identifying children with auditory perceptual defects.
Primary sternal plating in high-risk patients prevents mediastinitis☆ (2004)

Patients who benefited from sternal closure with rigid plate fixation showed a significant decrease in the incidence of post-operative mediastinitis when compared to similar population of patients whose sterna were closed with wire.
Maternal plasma viral load, zidovudine and mother-to-child transmission of HIV-1 in Africa: DITRAME ANRS 049a trial (2001)

High maternal viral load at inclusion strongly predicts MTCT of HIV in Africa. A short ZDV treatment regimen decreases significantly maternal viral load from its pretreatment level.
Ion adsorption and equilibrium distribution of charges in a cell of finite thickness (1990)

By using a self-consistent method the equilibrium distribution of charges in a liquid cell of finite thickness, when the adsorption phenomenon is present, is evaluated. The analysis is performed for the two limiting cases where the neutral density is fixed : either very weak (total dissociation), or very large (weak dissociation). The surface adsorbed charge is evaluated, by extending the classical Langmuir problem of adsorption to the case far from the saturation regime. The importance of the considered problem on the interfacial properties of liquid is discussed. In particular it is shown that by taking into account the surface electric field associated with the adsorbed charges, a non-local character of the anisotropic part of the anchoring energy of liquid crystals is expected. This agrees with recent experimental observations showing that nematic samples of different thicknesses, but with the same surface treatment, seem to have different anchoring energies.
Continuous recordings of skin conductance change during sleep (2000)

Using a new compact and stable device, skin conductance change (SCC) was measured in five female undergraduates during sleep. The SCC trends and waveforms were almost identical to those of simultaneously recorded skin potential activity (SPA). A gradual increase in sympathetic sweating during sleep was also observed using SCC. However, the confounding effects of a burst of positive skin potential responses usually seen in SPA were absent using SCC.
Experience with a Simplified Technique for the Treatment of Female Stress Urinary Incontinence (1990)

Over a 9-year period a simple procedure for the correction of stress urinary incontinence was performed in 86 consecutive patients, 31 of whom had failed a previous anti-incontinence procedure. Success was achieved in 81 cases (94%). Of the 5 failures, 2 were successfully treated with a repeat procedure. Operative time ranged from 14 to 49 min (median 27). The average hospital stay was 2 days. Because of its simplicity and reliability, this technique is recommended for the surgical correction of female stress urinary incontinence.