gebhart/patrepeval huggingface dataset:
Molecular structure of the teichuronic acid of Bacillus megaterium (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structure of the teichuronic acid of Bacillus megateriumR. J. Ivatt and C. GilvargCite this: Biochemistry 1978, 17, 19, 3997–4003Publication Date (Print):September 19, 1978Publication History Published online1 May 2002Published inissue 19 September 1978https://pubs.acs.org/doi/10.1021/bi00612a019https://doi.org/10.1021/bi00612a019research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Re-Evaluation of Some Thermodynamic Properties of Gadolinium Metal (1966)

The heat capacity of Gd metal has previously been measured over the temperature range 15 to 355\ifmmode^\circ\else\textdegree\fi{}K by M. Griffel et al. In this note, the $\ensuremath{\gamma}$ coefficient (16\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}4}$ cal/g atom ${\mathrm{deg}}^{2}$ in the original work) used in calculating the electronic specific heat of Gd has been replaced by the more recent value of 22\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}4}$, cal/g atom ${\mathrm{deg}}^{2}$. This leads to a slightly higher calculated Debye temperature and a subsequent readjustment of the lattice-specific-heat term. In addition, an error was discovered in the evaluation of the thermodynamic functions, particularly the (${{S}_{T}}^{0}$) term. A Simpson's-rule integration procedure was applied to the original heat-capacity data and the thermodynamic functions were re-evaluated. These changes lead to a magneticentropy calculation considerably closer to the complete spin-order entropy, RIn8, than was reported in the original work.
FPGA based wheelchair autonavigation for people with mobility issues (2015)

About 65 million people out of 650 million with disabilities in the world require wheelchairs for mobility. Only a minority of them have access to electric wheelchairs in developing and underdeveloped nations. The count is even less when it comes to sophisticated wheelchairs. These electric wheelchairs come with joystick control which is not suitable for people with stroke and spinal cord injury. In this research work we propose a FPGA based solution for automatic navigation of electric wheelchairs in indoor navigation. The house floor is divided into virtual grids with specific co-ordinates assigned to each grid. As a predefined path is fed into the system to reach a destination from a source the system works faster compared to the specific path finding algorithms for path calculation. The Matlab implementation and the Verilog HDL implementation, analysis, synthesis are discussed detailed in this paper.
Brief exercise increases circulating myeloperoxidase in boys with maturational influences observed at baseline (2008)

Rationale: Circulating myeloperoxidase (cMPO) is elevated in asthmatics suggesting leukocytes are inordinately activated in these individuals and may play a role in wheezing. Intriguingly, MPO is increased in response to exercise in non‐asthmatic adults, and exercise is a major trigger for bronchoconstriction in asthmatics. We hypothesized that exercise would increase cMPO in children and the response to exercise would be greater in asthmatics. Methods: Thirty‐one boys [9‐asthmatic late pubertal (AL), mean age 16.1 years; 8‐asthmatic early pubertal (AE), mean age 10.6 years; and 14 healthy control late pubertal (CL), mean age 17.0 years] performed 6–8 minutes of moderate exercise on a cycle ergometer. Blood was sampled at pre‐exercise (PE) and end‐exercise (EE). Results: CMPO did not differ between groups at PE (AL 8.0±1.6 ng/mL, AE 9.8±1.7 ng/mL, and CL 5.8±1.3 ng/mL); however, in 3 asthmatics PE cMPO was &gt;2SD above normal. All groups demonstrated a significant increase from PE to EE [AE Δ =3.9±1.5 ng/mL, p=0.013; AL Δ =4.5±1.4 ng/mL, p=0.0032; and CL Δ =5.0±1.1 ng/mL, p=0.0001] without a significant difference among groups. There was no correlation (|r|&lt;0.4) in PE cMPO or ΔcMPO to leukocytes, lung function, or fitness (BMI%, max VO2, VO2/kg). There was a significant negative correlation (r=0.54, p&lt;0.02) between PE cMPO and age in controls. Conclusions: Baseline cMPO may be influenced by maturational status. Brief exercise led to significant increases in cMPO in all children. The magnitude of difference was not related to asthma. We speculate that exercise‐induced asthma may result from an exaggerated response to leukocyte activation that occurs normally in children even with brief exercise.
Does Optimal Source Task Performance Imply Optimal Pre-training for a\n Target Task? (2021)

Fine-tuning of pre-trained deep nets is commonly used to improve accuracies\nand training times for neural nets. It is generally assumed that pre-training a\nnet for optimal source task performance best prepares it for fine-tuning to\nlearn an arbitrary target task. This is generally not true. Stopping source\ntask training, prior to optimal performance, can create a pre-trained net\nbetter suited for fine-tuning to learn a new task. We perform several\nexperiments demonstrating this effect, as well as the influence of the amount\nof training and of learning rate. Additionally, our results indicate that this\nreflects a general loss of learning ability that even extends to relearning the\nsource task.\n
Clasificación holística de la hipertrofia de labios menores (2021)

La hipertrofia de los labios menores o ninfas es una característica física bien descripta en muchos trabajos quirúrgicos previamente publicados. En muchos casos puede provocar sintomatología clínica o social que motivan la consulta de las pacientes.&#x0D; Aunque no existe un estándar anatómico establecido con respecto al tamaño de los labios menores para ser considerados “normales” la mayoría de los autores considera que dicha normalidad se basa en el concepto de que los labios mayores deben estar al mismo nivel o por debajo del borde de los labios mayores, y que deben converger superiormente y cubrir parcialmente el clítoris cuando se examina a la paciente en una posición anatómica, es decir, con las piernas levantadas.&#x0D; Las características anatómicas y el aspecto externo de estas estructuras en muchas pacientes interfieren con la higiene personal las relaciones sexuales e incomodan durante el uso de ropas ajustadas por lo que cada vez mas mujeres llegan a nuestra consulta tratando de encontrar una solución a lo que consideran un problema.&#x0D; La mayoría de las pacientes manifiestan que el aspecto de sus genitales afecta su autopercepción femenina y ese grado de afectación dependerá en mucho de la comparación entre pares o a través de las revistas o material visual de contenido sexual explícito.
The dependence of mesomorphic behaviour on the extent of hydrogen-bonding in sugar derived polyols (1998)

The thermotropic liquid crystalline properties of a variety of chiral and racemic dodecyloxy substituted polyols derived from carbohydrates were investigated as a function of the number of hydroxyl groups associated with the polyol unit. It was found that all of the materials exhibited smectic A* phases, and that the clearing points increased monotonically with the number of hydroxyl groups. The linear increase was found to be independent of stereochemical structure and the degree of optical purity. A model suggesting that the smectic A* phase has an internal microphase separated structure can be used to account for these observations.
Martin Bucer's Doctrine of Justification: Reformation Theology and Early Modern Irenicism. By Brian Lugioyo. Oxford Studies in Historical Theology. Oxford: Oxford University Press, 2010. xiv + 256 pp. $74.00 cloth. (2012)

Martin Bucer's Doctrine of Justification: Reformation Theology and Early Modern Irenicism. By Brian Lugioyo. Oxford Studies in Historical Theology. Oxford: Oxford University Press, 2010. xiv + 256 pp. $74.00 cloth. - Volume 81 Issue 4
ChemInform Abstract: A Short Synthesis of 3,6‐Disubstituted N‐2‐Thienyl/Aryl‐indoles. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol (2010)

Human kinesin Eg5, which plays an essential role in mitosis by establishing the bipolar spindle, has proven to be an interesting drug target for the development of cancer chemotherapeutics. Here, we report the crystal structures of the Eg5 motor domain complexed with enastron, dimethylenastron, and fluorastrol. By comparing these structures to that of monastrol and mon-97, we identified the main reasons for increased potency of these new inhibitors, namely the better fit of the ligand to the allosteric binding site and the addition of fluorine atoms. We also noticed preferential binding of the S-enantiomer of enastron and dimethylenastron to Eg5, while the R-enantiomer of fluorastrol binds preferentially to Eg5. In addition, we performed a multidrug resistance (MDR) study in cell lines overexpressing P-glycoprotein (Pgp). We showed that one of these inhibitors may have the potential to overcome susceptibility to this efflux pump and hence overcome common resistance associated with tubulin-targeting drugs.
Natural nutrient mixture effectively reduces collagen matrix contraction driven by human uterine smooth muscle cells (2006)

Based on these findings, we found that nutrients can effectively counteract uterine myometrial contraction and MMP activity in vitro, suggesting that pathophysiological mechanisms of abnormal uterine myometrial contractility can be counteracted by a combination of naturally occurring nutrients. These mechanisms might involve extracellular matrix remodeling.
Risk Factors for Pseudarthrosis After Surgical Site Infection of the Spine (2019)

This is the first known study to specifically identify risk factors for the development of symptomatic pseudarthrosis.
Unconventional superconductivity in Y5Rh6Sn18 probed by muon spin relaxation (2015)

Conventional superconductors are robust diamagnets that expel magnetic fields through the Meissner effect. It would therefore be unexpected if a superconducting ground state would support spontaneous magnetics fields. Such broken time-reversal symmetry states have been suggested for the high-temperature superconductors, but their identification remains experimentally controversial. We present magnetization, heat capacity, zero field and transverse field muon spin relaxation experiments on the recently discovered caged type superconductor Y5Rh6Sn18 ( TC= 3.0 K). The electronic heat capacity of Y5Rh6Sn18 shows a T(3) dependence below Tc indicating an anisotropic superconducting gap with a point node. This result is in sharp contrast to that observed in the isostructural Lu5Rh6Sn18 which is a strong coupling s-wave superconductor. The temperature dependence of the deduced superfluid in density Y5Rh6Sn18 is consistent with a BCS s-wave gap function, while the zero-field muon spin relaxation measurements strongly evidences unconventional superconductivity through a spontaneous appearance of an internal magnetic field below the superconducting transition temperature, signifying that the superconducting state is categorized by the broken time-reversal symmetry.
Application of Pattern Recognition Techniques to Breast Cancer Detection: Ultrasonic Analysis of 100 Pathologically Confirmed Tissue Areas (1982)

Ultrasonic pulse-echo rf waveform analysis and selected pattern recognition methods were applied to classification of breast tissue. Emphasis was placed on the classification of solid tissue areas since fluid areas are easily identified by present B-scan techniques. Pattern recognition techniques such as the Fisher Linear Discriminant (FLD), Probability Density Function (PDF) curves, jackknife estimate and committee vote were used to construct and evaluate a two class algorithm, malignant versus benign tissue areas. A data base consisting of frequency domain features from 100 pathologically confirmed tissue areas from 87 patients were used to train the algorithm. Algorithm performance was acquired via the generalized jackknife procedure to significantly reduce the bias frequently encountered in algorithm evaluation. Estimated values of algorithm performance are sensitivity and specificity values of 96 percent and 68 percent, respectively.
Deconstructing stereotypes: Stature, match-playing time, and performance in elite Women's World Cup soccer (2022)

Recruiting companies recommend elite female soccer players be ≥165 cm (5'5″) in stature. This study investigated if stature limits match-playing time and performance in elite World Cup soccer among players, positions, and countries. We hypothesized stature would not affect match-playing time or performance. Descriptive data were collected on 552 players from 2019 FIFA Women's World Cup. Odds ratios determined likelihood of starting for players <165 cm and ≥165 cm. ANOVAs compared playing time between stature groups, among positions, and between countries. Performance factors including assists, goals, attempts, corners, shots blocked, and defending blocks were reported. Independent t-tests compared differences between players (≥165 cm, < 165 cm). Data are reported, mean difference [95% confidence interval] [MD (95%CI)] and effect sizes (ES). On average, 32.3% of players were <165 cm. Of total players, no differences existed in total minutes (<i>F = </i>0.98, <i>p</i> = 0.32)<i>,</i> matches (<i>F</i> = 0.27 <i>p </i>= 0.59), or average minutes per match (<i>F = </i>0.48, <i>p </i>= 0.49) between stature groups, regardless of position. No differences existed in playing time between players <165 cm and ≥165 cm among any positions (<i>p</i> > 0.05), or between countries (<i>p</i> > 0.05). Taller mid-fielders exhibited greater performance in goals, assists, attempts, shots blocked, and defending blocks (MD [95%CI] ES; assists, -0.44[-0.76,-0.11]0.59, <i>p</i> = 0.009; goals, -0.35[-0.69,-0.01]0.44, <i>p</i> = 0.047); attempts, 3.14[1.38, 4.90]0.80, <i>p</i> = 0.001; corners, 2.04[0.12, 3.95]0.48, <i>p</i> = 0.037; shots blocked, 0.96[0.40, 1.51]0.75, <i>p</i> = 0.001; defending blocks, 0.43[0.32,0.82]0.48, <i>p</i> = 0.035), however, actual differences were minimal. Our findings indicate stature does not inhibit playing and performing elite women's soccer, as nearly one-third of players were <165 cm.
Toward Amide-Linked RNA Mimics:  Total Synthesis of 3‘-C Branched Uridine Azido Acid via an Ene−Iodolactonization Approach (2002)

[reaction: see text] A novel synthesis of 3'-C branched uridine azido acid has been accomplished by a sequence of stereoselective ene and iodolactonization reactions. Compared to traditional routes that start from carbohydrates, the present methodology is more flexible and can be further optimized by incorporation of novel future developments of synthetic chemistry. Because the key chemistry does not involve the 3'-C substituent, our route is a general approach to 3'-C alkyl nucleoside analogues.
Diagnosing and mapping pulmonary emphysema on X-ray projection images (2013)

To assess whether grating-based X-ray dark-field imaging can increase the sensitivity of X-ray projection images in the diagnosis of pulmonary emphysema and allow for a more accurate assessment of emphysema distribution. Lungs from three mice with pulmonary emphysema and three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Median signal intensities of transmission (T), dark-field (V) and a combined parameter (normalized scatter) were compared between emphysema and control group. To determine the diagnostic value of each parameter in differentiating between healthy and emphysematous lung tissue, a receiver-operating-characteristic (ROC) curve analysis was performed both on a per-pixel and a per-individual basis. Parametric maps of emphysema distribution were generated using transmission, dark-field and normalized scatter signal and correlated with histopathology. Transmission values relative to water were higher for emphysematous lungs than for control lungs (1.11 vs. 1.06, p&lt;0.001). There was no difference in median dark-field signal intensities between both groups (0.66 vs. 0.66). Median normalized scatter was significantly lower in the emphysematous lungs compared to controls (4.9 vs. 10.8, p&lt;0.001), and was the best parameter for differentiation of healthy vs. emphysematous lung tissue. In a per-pixel analysis, the area under the ROC curve (AUC) for the normalized scatter value was significantly higher than for transmission (0.86 vs. 0.78, p&lt;0.001) and dark-field value (0.86 vs. 0.52, p&lt;0.001) alone. Normalized scatter showed very high sensitivity for a wide range of specificity values (94% sensitivity at 75% specificity). Using the normalized scatter signal to display the regional distribution of emphysema provides color-coded parametric maps, which show the best correlation with histopathology. In a murine model, the complementary information provided by X-ray transmission and dark-field images adds incremental diagnostic value in detecting pulmonary emphysema and visualizing its regional distribution as compared to conventional X-ray projections.
Myxobacteria: Chemical Diversity and Screening Strategies (2014)

Myxobacteria have proven to be an excellent source of natural products with a broad range of biological activities. The combination of unique structures and novel mechanisms of action makes myxobacteria-derived natural products excellent candidates for drug discovery programs. This chapter provides an update on the isolation and biological activity of compounds reported from myxobacteria since the last review published in 2009. Additionally, an overview of some of the approaches used in this research group to identify novel scaffolds from myxobacteria has been provided. During the last three years, approximately 60 new myxobacteria-derived natural products showing unique activities and amazing structural diversity have been reported. The screening of these new myxobacterial strains is carried out using NMR and LC-ESIMS profiling for unique chemical constituents followed by their isolation and broad evaluation in diverse biological assays.
RIBA, una herramienta cuantitativa de seguimiento y evaluación de riesgos (2002)

La asunción de riesgos puede implicar la posibilidad de perder, pero esto no significa necesariamente que tenga que haber un perde-dor. Dado que los proyectos de renovación y mantenimiento se basan cada vez con más frecuencia en el rendimiento obtenible, la evaluación de riesgos ha evolucionado hasta convertirse en un valioso instrumento para las ofertas de ABB a de sus clientes. La evaluación RiBA (Risk-Based Assessment) basada en riesgos es una herramienta de software desarrollada por ABB con el fin de constituir una sólida plataforma para la gestión de riesgos y para el desarrollo de estrategias que permitan reducir los mismos en proyectos competitivos
Low Power Interstitial Laser Hyperthermia - Potential For Clinical Use (1989)

The use of single fibre for interstitial low power laser hyperthermia (1-2 W) is associated with the development of a lesion of thermal necrosis measuring 1.4-1.8 cm in liver, pancreas and prostate. These lesions heal safely and can be well visualised with ultrasound. The use of a multiple fibre (4) system has enabled the production of larger lesions in all these organs which take a longer time to heal than single fibre lesions, but do so safely. Again, ultrasound enables these lesions to be studied in their creation and in their resolution. Following this experimental work early clinical application to a variety of otherwise untreatable tumours (breast, skin, pancreas and liver) has been carried out. This has resulted in a partial response in all treated and complete response in a smaller number of cases. The method appears to be safe and practical for the treatment of some tumours.
Alemtuzumab Treatment of Multiple Sclerosis (2013)

Alemtuzumab is a humanized monoclonal antibody directed against CD52. A single cycle of alemtuzumab, administered over 5 days, depletes lymphocytes. Reconstitution causes prolonged alterations in the lymphocyte repertoire, with relatively increased regulatory T-cell numbers and reduced naïve T cells. It is currently approved for the treatment of B-cell chronic lymphocytic leukemia and is being considered for licensing for multiple sclerosis (MS).When first used, alemtuzumab successfully reduced relapses and new lesion formation based on magnetic resonance imaging in people with progressive MS, but this cohort continued to accumulate disability, associated with progressive cerebral atrophy, presumably due to axonal degeneration. From this experience, we advocated that immunotherapies should be given early in the course of the disease. Since then, one phase II and two phase III trials have shown that alemtuzumab reduces the relapse rate, compared with the active comparator interferon beta-1a (IFNβ-1a), in treatment-naïve and treatment-experienced MS up to 10 years from disease onset. Furthermore, in two of these trials, alemtuzumab reduced the risk of accumulating disability compared with IFNβ-1a; indeed alemtuzumab treatment led to an improvement in disability and reduction in cerebral atrophy. Safety issues are infusion-associated reactions, mainly controlled by methyl-prednisolone, antihistamines, and antipyretics; mild to moderate infections; and autoimmunity. After 5 years, 30 to 40% of alemtuzumab patients have developed autoimmunity, largely against the thyroid gland, but rarely (2%) against platelets in immune thrombocytopenia, and in a few cases, Goodpasture's renal syndrome.Alemtuzumab is an effective therapy for early relapsing-remitting multiple sclerosis, offering disability improvement at least to 5 years after treatment. Its use requires careful monitoring so that potentially serious side effects can be treated early and effectively.
Emergence of room-temperature ferroelectricity at reduced dimensions (2015)

The enhancement of the functional properties of materials at reduced dimensions is crucial for continuous advancements in nanoelectronic applications. Here, we report that the scale reduction leads to the emergence of an important functional property, ferroelectricity, challenging the long-standing notion that ferroelectricity is inevitably suppressed at the scale of a few nanometers. A combination of theoretical calculations, electrical measurements, and structural analyses provides evidence of room-temperature ferroelectricity in strain-free epitaxial nanometer-thick films of otherwise nonferroelectric strontium titanate (SrTiO3). We show that electrically induced alignment of naturally existing polar nanoregions is responsible for the appearance of a stable net ferroelectric polarization in these films. This finding can be useful for the development of low-dimensional material systems with enhanced functional properties relevant to emerging nanoelectronic devices.