gebhart/patrepeval huggingface dataset:
Abstract 1812: XCE853: A novel PDI inhibitor that inhibits proliferation of human tumor cells in vitro, ex-vivo and in vivo (2014)

Abstract XCE853 was originally identified within a family of synthetic compounds displaying a preferential antiproliferative activity on drug resistant human cancer cells (Gutmann et al, AACR annual meeting, 2013). XCE853 induced an irreversible cytolysis of human tumor cells after a short in vitro exposure independently of efflux pumps leading to a tumor cell death by autophagy and particles release (vesicles or protein aggregates). The interest for XCE853 has been reinforced by three in vitro observations: 1) XCE853 inhibits the recombinant human enzyme PDI recognized as one novel target linked to drug resistance 2) XCE853 has a unique antiproliferative profile compared to the NCI database compounds when using the NCI Compare assay and 3) XCE853 has no activity on human normal prostate cells even at high concentrations whereas XCE shows an IC50 in the nanomolar range on human tumoral cells. In addition, the ex-vivo approach using fresh human tumor explants cultivated in 3 dimensions with low concentrations of XCE853 has shown a strong decrease of the proliferation (KI-67 labeling) with an apoptosis induction (Caspase-3 labeling) of Head &amp; Neck cancers following 24h of exposure. Finally, XCE853 which displayed an excellent oral bioavailability in mouse is able to block growth of human ovarian cancer using in vivo xenograft model leading to a complete tumor growth arrest even after the stop of the treatment. Altogether, these data support further efforts on this drug candidate to initiate the preclinical studies and to define the most relevant human tumor types. Citation Format: Gregoire P. Prevost, Shili Xu, Marine Garrido, Maria Serova, Olivier DE Vewer, Christian Gespach, Jean-François Briand, Annemilaï Tijeras-Raballand, Mathieu Gutmann, An Hendrix, Michele Sabbah, Anne Chachereau, Armand de Gramont, Nouri Neamati, Denis Carniato, Marc-Henry Pitty, Paul Foster. XCE853: A novel PDI inhibitor that inhibits proliferation of human tumor cells in vitro, ex-vivo and in vivo. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1812. doi:10.1158/1538-7445.AM2014-1812
Challenges in intrusion detection for wireless ad-hoc networks (2003)

This paper presents a brief survey of current research in intrusion detection for wireless ad-hoc networks. In addition to examining the challenges of providing intrusion detection in this environment, this paper reviews current efforts to detect attacks against the ad-hoc routing infrastructure, as well as detecting attacks directed against the mobile nodes. This paper also examines the intrusion detection architectures that may be deployed for different wireless ad-hoc network infrastructures, as well as proposed methods of intrusion response.
ChemInform Abstract: The Tetrazolylmethyl and Related Radicals: A Convenient Access to Tetrazoles and Other Heterocyclic Derivatives. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Some aspects of FMDV-production in growing cells and a closed system for concentration of FMDV by polyethylene glycol. (1979)

Different commercially available peptone preparations, all derived by enzymatic digestion of meat, were tested for their ability to replace the individual amino acids and polyethylene glycol (PEG)-treated serum in BHK suspended cell culture growth medium. Cell growth was not impaired if the individual amino acids were replaced by 3 g/l of peptone in combination with 3 g/l LAH and 5% PEG-treated bovine serum. The concentration of the latter could be reduced to 1% by gradually lowering the concentration in successive cell passages. No significant differences in growth stimulating properties were observed between the peptone preparations. The virus produced was concentrated and partly purified by precipitation with PEG, collection of the precipitate by filter-aid filtration and direct elution from filter cake in the filter by pumping one tenth the original volume of buffer through the filter. The whole procedure was performed in a simple closed system, offering maximum guarantee of bacteriological sterility and preventing virus aerosol formation in the surroundings.
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas (2012)

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were compared for HIST1H3B, IDH, ATRX and TP53 mutations, copy number alterations and clinical outcome. K27M-H3.3 occurred in 71 %, TP53 mutations in 77 % and ATRX mutations in 9 % of DIPGs. ATRX mutations were more frequent in older children (p < 0.0001). No G34V/R-H3.3, IDH1/2 or H3.1 mutations were identified. K27M-H3.3 DIPGs showed specific copy number changes, including all gains/amplifications of PDGFRA and MYC/PVT1 loci. Notably, all long-term survivors were H3.3 wild type and this group of patients had better overall survival. K27M-H3.3 mutation defines clinically and biologically distinct subgroups and is prevalent in DIPG, which will impact future therapeutic trial design. K27M- and G34V-H3.3 have location-based incidence (brainstem/cortex) and potentially play distinct roles in pediatric GBM pathogenesis. K27M-H3.3 is universally associated with short survival in DIPG, while patients wild-type for H3.3 show improved survival. Based on prognostic and therapeutic implications, our findings argue for H3.3-mutation testing at diagnosis, which should be rapidly integrated into the clinical decision-making algorithm, particularly in atypical DIPG.
Röd flagga över Hongkong: En studie av svenska företags perceptioner av en politisk risk (2004)

A1144Problem: I och med att ingen visste hur det socialistiska Kina skulle behandla det genomkapitalistiska Hongkong efter overtagandet var framtiden for Hongkongs foretag att beteckna som osaker. ...
Data from A Molecular Diagnostic Test for Distinguishing Lung Adenocarcinoma from Malignant Mesothelioma Using Cells Collected from Pleural Effusions (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Patients with malignant mesothelioma or adenocarcinoma of the lung often present with respiratory complications associated with a malignant pleural effusion. Distinguishing between these malignancies is frequently problematic, as many of the clinical, cytologic, and histologic features of the diseases overlap. Following cytologic analysis of pleural effusions, subsequent confirmatory tissue biopsies involve increased patient morbidity and expense. We have therefore designed a gene expression–based test to classify the primary tumor causing a malignant pleural effusion, using cells collected from the effusion itself.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We have used microarray data for 190 lung adenocarcinomas and 33 malignant mesotheliomas to identify genes differentially expressed between the two diseases. Genes expressed in normal mesothelial cells were removed, allowing the development of a PCR-based test to measure the expression of genes that discriminate between mesothelioma and lung adenocarcinoma from cytology specimens.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Applying an real-time PCR–based assay involving 17 genes to 13 independent samples from biopsy-proven malignant mesothelioma and lung adenocarcinomas resulted in the correct identification of all samples.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; We have developed a test that is able to distinguish between lung adenocarcinoma and mesothelioma in cells collected from pleural effusions.&lt;/p&gt;&lt;/div&gt;
Towards a Digital Knowledge Base of Circular Design Examples through Product Teardowns (2022)

Design of more circular products is key to achieving Sustainable Development Goal 12, Responsible Consumption and Production. However, many designers lack the knowledge and confidence to bring aspects of circular design into their design practices. One problem is the lack of examples on how circular design is implemented in different types of products and their components. In this work, we present a framework to generate a digital knowledge base of circular design examples from product teardowns (product dissections). Leveraging teardowns, a commonly practiced activity among product designers, can allow the knowledge base to include rich and up-to-date design examples and help inspire future design. The knowledge base covers three categories of circular design aspects: reliability, RRU (repair, reuse, upgrade), and recycling. Under each aspect, we generate a comprehensive list of prompts to guide designers to analyze the product and collect circular design examples. A subset of prompts is showcased in a study of a newly released laptop. We also gathered feedback and suggestions for future developments from experienced design practitioners.
Potential Induced Degradation Effects on Crystalline Silicon Cells with Various Antireflective Coatings (2012)

The first experiences with potential induced degradation (PID) of silicon solar cells have been presented in literature since 1989 [1-4]. It has been shown that PID may cause power losses of more than 30% for modules out in the field. Critical issues on the cell level are the SiNx anti-reflective coatings (ARC), their deposition method, the emitter thickness and metallization (thus influencing the electrical series resistance). The leakage current was found as an indicator for the intensity of degradation. Moreover, different test methods to prove the stability or susceptibility of samples have been presented. In this paper we are showing the influence of the anti-reflection coating to provoke PID and the ability of silicon nitrite layers to prevent PID. For each layer structure, at least four different designs have been manufactured and tested for their stability against PID. To do so, it was necessary to find an appropriate test sequence, which would show polarization effects in an adequate time frame, while there is no standard procedure available that addresses this problem for the time being. Furthermore, it has been necessary to develop suitable reference samples to compare the results and to prove the repeatability of the test sequences. The experiment has been divided into two parts: The pre-evaluation has been realized with small onecell mini-modules to probe the adequate testing parameters and to analyze the leakage currents for various prone samples. During the second part, we also investigated the reversibility of PID - depending on the state of degradation of these samples - to check whether PID is one 100% reversible, or whether the degradation mechanism also shows an irreversible part.
Theoretical Study of the Adsorption and Dissociation of Oxygen on Pt(111) in the Presence of Homogeneous Electric Fields (2005)

The effect of homogeneous electric fields on the adsorption energies of atomic and molecular oxygen and the dissociation activation energy of molecular oxygen on Pt(111) were studied by density functional theory (DFT). Positive electric fields, corresponding to positively charged surfaces, reduce the adsorption energies of the oxygen species on Pt(111), whereas negative fields increase the adsorption energies. The magnitude of the energy change for a given field is primarily determined by the static surface dipole moment induced by adsorption. On 10-atom Pt(111) clusters, the adsorption energy of atomic oxygen decreased by ca. 0.25 eV in the presence of a 0.51 V/Å (0.01 au) electric field. This energy change, however, is heavily dependent on the number of atoms in the Pt(111) cluster, as the static dipole moment decreases with cluster size. Similar calculations with periodic slab models revealed a change in energy smaller by roughly an order of magnitude relative to the 10-atom cluster results. Calculations with adsorbed molecular oxygen and its transition state for dissociation showed similar behavior. Additionally, substrate relaxation in periodic slab models lowers the static dipole moment and, therefore, the effect of electric field on binding energy. The results presented in this paper indicate that the electrostatic effect of electric fields at fuel cell cathodes may be sufficiently large to influence the oxygen reduction reaction kinetics by increasing the activation energy for dissociation.
Shear Wave Tensiometry Tracks Reductions in Collateral Ligament Tension Due to Incremental Releases (2021)

Surgeons routinely perform incremental releases on overly tight ligaments during total knee arthroplasty (TKA) to reduce ligament tension and achieve their desired implant alignment. However, current methods to assess whether the surgeon achieved their desired reduction in the tension of a released ligament are subjective and/or do not provide a quantitative metric of tension in an individual ligament. Accordingly, the purpose of this study was to determine whether shear wave tensiometry, a novel method to assess tension in individual ligaments based on the speed of shear wave propagation, can detect changes in ligament tension following incremental releases. In seven medial and eight lateral collateral porcine ligaments (MCL and LCL, respectively), we measured shear wave speeds and ligament tension before and after incremental releases consisting of punctures with an 18-gauge needle. We found that shear wave speed squared decreased linearly with decreasing tension in both the MCL (r^2 avg = 0.76) and LCL (r^2 avg = 0.94). We determined that errors in predicting tension following incremental releases were 24.5 N and 12.2 N in the MCL and LCL, respectively, using specimen-specific calibrations. These results suggest shear wave tensiometry is a promising method to objectively measure the tension reduction in released structures. Clinical Significance: Direct, objective measurements of the tension changes in individual ligaments following release could enhance surgical precision during soft tissue balancing in TKA. Thus, shear wave tensiometry could help surgeons reduce the risk of poor outcomes associated with overly tight ligaments, including residual knee pain and stiffness.
Temperature compensation of crystal oscillators using an Artificial Neural Network (2012)

Temperature Compensated Crystal Oscillators (TCXOs) are widely used and well known frequency control products. Their performance has improved over the decades with the advent of newer and improved technologies. Evolution of the TCXO from resistor thermistor networks to modern polynomial generators has pushed TCXO temperature stabilities to nearly +/-100ppb deviation over the industrial temperature range of -40 to +85°C. Even with these great advances, users always need tighter stabilities. This paper focuses on a new temperature compensation technique for crystal oscillators. Through the use of an Artificial Neural Network (ANN), temperature compensation of AT cut crystal oscillators can be achieved with better than +/-10ppb stability over the industrial temperature range (-40 to +85 °C). This is more than a 10 fold improvement over state of the art polynomial function generator compensation. The theory of this compensation method will be discussed, and data showing the results of temperature compensation on actual oscillators will be presented.
Standardized quality control workflow to evaluate the reproducibility and differentiation potential of human iPSCs into neurons (2021)

Abstract Induced pluripotent stem cells (iPSCs) derived from human somatic cells have created new opportunities to generate disease-relevant cells. Thus, as the use of patient-derived stem cells has become more widespread, having a workflow to monitor each line is critical. This ensures iPSCs pass a suite of quality control measures, promoting reproducibility across experiments and between labs. With this in mind, we established a multistep workflow to assess our newly generated iPSCs for variations and reproducibility relative to each other and iPSCs obtained from external sources. Our benchmarks for evaluating iPSCs include examining iPSC morphology and proliferation in two different media conditions and evaluating their ability to differentiate into each of the three germ layers, with a particular focus on neurons. Genomic integrity in the human iPSCs was analyzed by G-band karyotyping and a qPCR-based test for the detection of hotspot mutations test. Cell-line identity was authenticated by Short Tandem Repeat (STR) analysis. Using standardized dual SMAD inhibition methods, all iPSC lines gave rise to neural progenitors that could subsequently be differentiated into cortical neurons. Neural differentiation was analyzed qualitatively by immunocytochemistry and quantitatively by qPCR for progenitor, neuronal, cortical, and glial markers. Taken together, we present a multistep quality control workflow to evaluate variability and reproducibility across and between iPSCs.
The practice of Chinese medicine = [Chung yao chen chiu chih liao hsüeh] : the treatment of disease with acupuncture and Chinese herbs (1994)

Headaches. Dizziness. Breathlessness. Wheezing. Asthma. Allergic Rhinitis. Sinusitis. Cough. Mental-Emotional Problems. Insomnia. Tinnitus. Tiredness. Chest Painful Obstruction Syndrome. Epigastric Pain. Hypochondrial Pain. Abdominal Pain. Abdominal Masses. Diarrhoea. Constipation. Painful Urination Syndrome. Enuresis and Incontinence. Oedema. Painful Obstruction Syndrome. Lower Back-Ache and Sciatica. Myalgic Encephalomyelitis. Parkinson's Disease. Wind-Stroke. Atrophy Syndrome. Multiple Sclerosis. Bleeding. Dysmenorrhoea. Menorrhagia and Metrorrhagia. Pre-Menstrual Tension. Common Cold and Influenza. Appendices. Glossary of Chinese Terms. Bibliography. Index
Internet Printing Protocol/1.1: IPP URL Scheme (2003)

by expanding and clarifying Section 5, "IPP URL Scheme", of RFC 2910. An "ipp" URL is used to specify the network location of a print service that supports the IPP Protocol (RFC 2910), or of a network resource (for example, a print job) managed by such a print service.
An Assessment of Environmental Costs Associated with Crude Oil Pipeline Damage Caused by Earthquakes (1992)

This paper presents a methodology for assessing the risk of environmental contamination from oil pipeline leaks caused by earthquakes. Risk is measured both as volume of oil released and remediation cost. The methodology was developed for use on a regional scale and thus relies on a limited amount of input data. Monte Carlo techniques are used to simulate earthquake events, while a deterministic model is used to estimate the volume of oil released at a particular site. A library of cost models is used to estimate the contamination and resulting remediation cost based on the volume of oil released and the general site conditions. This methodology has been implemented in a computer program, OILOSS, and the results are presented as frequency of exceedance curves for volume of oil released and cost of remediation. The methodology is applied to two crude oil pipelines near the New Madrid Seismic Zone (NMSZ) and preliminary results are presented. This study is being sponsored by a grant from the National Center for Earthquake Engineering Research (NCEER).
Decision Support Systems: Directed and Nondirected Change (1990)

The Decision Support Systems (DSS) literature is in general agreement that use of DSS leads to individual and organizational change, but there is no consensus as to whether DSS and their designers serve as agents for directed or nondirected change. Researchers have proceeded from two different sets of premises, drawing different conclusions about the nature of DSS. This paper considers both views, examining how differences in designers' attitudes toward change agency ought to be manifest in the features of the DSS they implement. Two attributes of DSS, “system restrictiveness” and “decisional guidance,” are discussed as the basis for understanding differences in DSS following from differences in designer attitudes toward change. Using these two attributes, four DSS strategies for directed change and five strategies for nondirected change are presented.
Randomized controlled trial of S-1 maintenance therapy in metastatic esophagogastric cancer – the multinational MATEO study (2017)

NCT02128243 (date of registration: 29-04-2014).
The wetting behavior of NiAl and NiPtAl on polycrystalline alumina (2007)

In order to understand the beneficial effect of Pt on the adherence of thermally grown alumina scales, sessile drop experiments were performed to study the wetting of poly-crystalline alumina by nickel-aluminum alloys with or without platinum addition where the amount of Pt ranged from 2.4 to 10 at.%. Subsequent interfacial structure was evaluated using atomic force microscopy. Platinum addition enhances the wettability of NiAl alloys on alumina, reduces the oxide/alloy interface energy and increases the interfacial mass transport rates.
Monolithic LaBr3:Ce crystals on silicon photomultiplier arrays for time-of-flight positron emission tomography (2012)

Positron emission tomography detectors based on monolithic scintillation crystals exhibit good spatial and energy resolution, intrinsically provide depth-of-interaction information, have high γ-photon capture efficiency, and may reduce the manufacturing costs compared to pixelated crystal arrays. Here, we present the characterization of a detector consisting of a 18.0 mm×16.2 mm×10.0 mm monolithic LaBr₃:5%Ce scintillator directly coupled to a 4×4 array of silicon photomultipliers. An energy resolution of 6.4% full-width-at-half-maximum (FWHM) was obtained. The point-spread-function (PSF) was determined for different regions of the detector. The full-width-at-half-maximum (FWHM) of the PSF was measured to be <1.5 mm at the center of the detector and <1.7 mm averaged over the entire crystal. Both values are not corrected for the ~0.6 mm FWHM test beam diameter. Furthermore, the influence of edge effects was investigated. We found that near the edges of the detector the spatial resolution degrades to 2.2 mm (FWHM), and a bias in the position estimates, up to 1.5 mm, was observed. Moreover, the coincidence resolving time for two identical detectors in coincidence was measured to be as small as ~198 ps FWHM.