gebhart/patrepeval huggingface dataset:
Antiobiotiques et antibiorésistance, un avatar singulier de l’histoire planétaire (2016)

La résistance des bactéries aux antibiotiques est le résultat d’un processus d’adaptation très ancien, accéléré par les usages immodérés des antibiotiques au xxe siècle, tant en ce qui concerne la santé humaine, que la santé animale. Ce phénomène constitue une menace majeure pour la médecine dont les pratiques et les avancées se trouvent ainsi remises en question. Le problème a aussi des aspects globaux et systémiques car la résistance des bactéries a suivi les évolutions économiques et géopolitiques des xxe et xxie siècles. Elle prend, de nos jours, une ampleur particulière du fait de la globalisation économique ainsi que des échanges touristiques et médicaux.
Conformer analysis and intramolecular excimer formation with the meso and racemic diastereoisomers of 2,4-di(2-pyrenyl)pentane: comparison of NMR and single-photon-counting data (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformer analysis and intramolecular excimer formation with the meso and racemic diastereoisomers of 2,4-di(2-pyrenyl)pentane: comparison of NMR and single-photon-counting dataPeter. Reynders, Herbert. Dreeskamp, Wolfgang. Kuehnle, and Klaas A. ZachariasseCite this: J. Phys. Chem. 1987, 91, 15, 3982–3992Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/j100299a013https://doi.org/10.1021/j100299a013research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
TQM Practices in Public Sector (2016)

This study aims to discuss the evolution, principles, and stages of total quality management (TQM) in public health care organizations. It also makes a comparison that how case organizations think about quality and TQM along with its applicability within public sector. The study can be categorized as qualitative research. The data is collected from semi structural interviews of the informants and the concerning documents, which consist of strategy, policy papers and audit reports of the case organizations. Altogether there are two case organizations. Furthermore, data is analyzed with the help of content analysis. Most vital issues in TQM practices are its comprehensiveness, and its application in such a way which is appropriate for the organization, with a logical way of operation and the participation of management and personnel. Training, guidance, teamwork, involvement and learning are imperative for achieving a continuous improvement culture and are vital elements when adopting TQM. Managers should learn from the experience of TQM implementers by studying expected challenges and pitfalls. They should also pay more attention to the crucial role of all stakeholders in the TQM implementation. The study could be quite valuable from a strategic perspective in providing guidelines to build up a proper plan for TQM practices more promptly. The paper also manages to shed light on TQM practices of public service organizations by comparing their current approaches to quality.
Heterogeneity of human platelets (1969)

In the previous communication, suggestive evidence was presented for large-heavy platelets being "young" platelets and light-small platelets being "old" platelets. Large-heavy, light-small, and total human platelet populations were compared with respect to their platelet function. After addition of adenosine diphosphate (ADP), thrombin, or epinephrine, platelet aggregation time was 3.0-, 4.5-, and 3.3-fold shorter with large-heavy platelets compared with light-small platelets, and large-heavy platelets released 3.7-, 7.6-, and 8.1-fold greater adenosine triphosphate (ATP) into the medium, respectively, than did light-small platelets. After platelet aggregation by thrombin or epinephrine, large-heavy platelets released 6.0- and 3.8-fold more ADP into the medium than did light-small platelets. After platelet aggregation by ADP, light-small platelets consumed 5.9-fold greater added extracellular ADP than did large-heavy platelets.Large-heavy platelets aggregated by ADP, thrombin, or epinephrine released 9.1-, 8.5-, and 12.7-fold greater platelet factor 4 than light-small platelets similarly treated.
Progress in the Formulation and Delivery of Somatostatin Analogs for Acromegaly (2017)

A 14 amino acid cystin bridge containing neuropeptide was discovered in 1973 and designated as growth hormone-inhibiting hormone, in other words, somatostatin. Its discovery led to the synthesis of three analogs which were licensed for the treatment of acromegaly: octreotide, lanreotide and pasireotide. Somatostatin analogs are currently approved only as either subcutaneous or intramuscular long-acting injections. We examine the challenges that must be overcome to create oral formulations of somatostatin analogs and examine selected clinical trial data. While octreotide has low intestinal permeability, similar to almost all other peptides, it has an advantage of being more stable against intestinal peptidases. The development of new oral formulation strategies may eventually allow for the successful oral administration of potent somatostatin analogs with high therapeutic indices.
Supplementary Data 6 from Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma (2023)

&lt;p&gt;Enrichment of transcription factor consensus binding motifs in regulatory elements predictive of gene expression associated with poor overall survival.&lt;/p&gt;
Simple HPLC Detector for the Detection of NIR Dyes (1995)

Abstract The development and evaluation of a simple, silicon photodiode-based near infrared HPLC detector is presented. The instrument was evaluated using dyes fluorescing in the near infrared region. It was found to have sensitivity comparable with those based on sensors built around high voltage photmultiplier tubes.
Steroid metabolism in ocular tissues of the rabbit. (1976)

The metabolism of cortisol and other steroids was studied in normal untreated rabbit iris-ciliary body and cornea as part of an investigation into the mechanism of glucocorticoid-induced glaucoma. Cortisol is readily converted to the inactive metabolite cortisone by these eye tissues indicating the presence of an 11beta-oxidoreductase system. This reaction is reversible with cortisone being converted to cortisol in the presence of appropriate cofactor. However, due to the absence of a (or as yet undetectable) cortisol-A-ring-reductase system (rate-limiting reaction) the steroid is not irreversibly metabolized to biologically inactive compounds. The 11beta-oxidoreductase system readily converts other C21-11beta-hydroxysteroids, such as corticosterone, to its appropriate C21-11-ketosteroid (11-dehydrocorticosterone). Some C21-steroids lacking the 11-hydroxyl group (11-deoxycortisol, 11-deoxycorticosterone) remain virtually unmetabolized (exception to this was found with progesterone). Evidence of a C21-steroid A-ring reductase system was found only when cortisone and progesterone were used as substrates. However, testosterone a C19 steroid was converted to clearly identifiable A-ring reduced and 17beta-and 3alpha(beta)-oxidoreduced metabolites, thus indicating the presence of testosterone A-ring reductase, 17beta-and 3alpha(beta)-oxidoreductase systems in the eye tissues studied. The presence of a steroid 5alpha(beta)-reductase for some steroids but not for cortisol indicates a distinct substrate specificity for this enzyme system in the eye tissues.
Biodegradable polymers as biomaterials (1995)

Biomaterials are used in prostheses and medical devices for different purposes. Polymers are the most diverse class of biomaterials. All biomaterials must meet certain criteria and regulatory requirements before they can be qualified for use in medical applications. Biocompatibility is one of the most important requirements. Both nondegradable polymers are designed to degrade in vivo in a controlled manner over a predetermined time. The main mechanism of in vivo degradation of polymers is 'hydrolytic degradation', in which enzymes may also play a role (i.e. 'enzymatic degradation'). Both natural e.g., collagen, and synthetic e.g., poly(alpha-hydroxy) acids, biodegradable polymers are used in biomedical applications. Many of the current polymers and processing techniques need to be improved in order to produce polymers with better performance in biological media. An important trend in related research and development is the synthesis of novel polymers, which would exhibit improved biocompatibility, and be bioresponsive.
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease (1993)

Tacrine hydrochloride concentration is valuable in predicting the development of adverse effects, and its measurement may improve the use of the drug.
Measurement of prompt and nonprompt $$\mathrm{J}/{\psi }$$ J / ψ production in $$\mathrm {p}\mathrm {p}$$ p p and $$\mathrm {p}\mathrm {Pb}$$ p Pb collisions at $$\sqrt{s_{\mathrm {NN}}} =5.02\,\text {TeV} $$ s NN = 5.02 TeV (2017)

This paper reports the measurement of [Formula: see text] meson production in proton-proton ([Formula: see text]) and proton-lead ([Formula: see text]) collisions at a center-of-mass energy per nucleon pair of [Formula: see text] by the CMS experiment at the LHC. The data samples used in the analysis correspond to integrated luminosities of 28[Formula: see text] and 35[Formula: see text] for [Formula: see text] and [Formula: see text] collisions, respectively. Prompt and nonprompt [Formula: see text] mesons, the latter produced in the decay of [Formula: see text] hadrons, are measured in their dimuon decay channels. Differential cross sections are measured in the transverse momentum range of [Formula: see text], and center-of-mass rapidity ranges of [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]). The nuclear modification factor, [Formula: see text], is measured as a function of both [Formula: see text] and [Formula: see text]. Small modifications to the [Formula: see text] cross sections are observed in [Formula: see text] relative to [Formula: see text] collisions. The ratio of [Formula: see text] production cross sections in [Formula: see text]-going and Pb-going directions, [Formula: see text], studied as functions of [Formula: see text] and [Formula: see text], shows a significant decrease for increasing transverse energy deposited at large pseudorapidities. These results, which cover a wide kinematic range, provide new insight on the role of cold nuclear matter effects on prompt and nonprompt [Formula: see text] production.
Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. (1994)

Two new members (Sar1a and Sar1b) of the SAR1 gene family have been identified in mammalian cells. Using immunoelectron microscopy, Sar1 was found to be restricted to the transitional region where the protein was enriched 20-40-fold in vesicular carriers mediating ER to Golgi traffic. Biochemical analysis revealed that Sar1 was essential for an early step in vesicle budding. A Sar1-specific antibody potently inhibited export of vesicular stomatitis virus glycoprotein (VSV-G) from the ER in vitro. Consistent with the role of guanine nucleotide exchange in Sar1 function, a trans-dominant mutant (Sar1a[T39N]) with a preferential affinity for GDP also strongly inhibited vesicle budding from the ER. In contrast, Sar1 was not found to be required for the transport of VSV-G between sequential Golgi compartments, suggesting that components active in formation of vesicular carriers mediating ER to Golgi traffic may differ, at least in part, from those involved in intra-Golgi transport. The requirement for novel components at different stages of the secretory pathway may reflect the recently recognized differences in protein transport between the Golgi stacks as opposed to the selective sorting and concentration of protein during export from the ER.
017 Laminin 10 in Wound Reepithelization and Angiogenesis (2008)

Extracellular matrix laminins are the major noncollagenous components in the basement membrane zones (BMZ) and influence a variety of important biological processes including cell attachment, migration, and tissue development. A newly discovered laminin family member, laminin 10 (alpha 5, beta 1, and gamma 1), is found a major laminin present in the BMZs at the dermal-epidermal junction and dermal microvascular vessels. We examined the roles of laminin 10 in cutaneous wound repair in vitro and in vivo. Purified laminin 10 protein promoted human keratinocyte spreading and attachment, which is mediated by integrins. In human wound lesions, immunoperoxidase staining, with antibody 4C7 specific to laminin alpha 5 chain, stained strongly positive for laminin 10 in newly formed BMZs of epidermis and dermal blood vessels. Using a laminin 10 alpha 5 chain knockout mouse, excisional wounds in this model had abnormal reepithelialization and decreased granulation tissue formation. Transmission electron microscopy analysis of the BMZ of the mutant skin showed discontinuous lamina densa formation in areas between hemidesmosomes. In a porcine burn wound model, Reverse Transcription and Polymerase Chain Reaction analysis found significant higher expression of laminin 10 shortly after wounding and persisted through day 21, peaking at day 10. This expression pattern is consistent with the reconstitution of BMZs in the epidermis and microvascular blood vessels. These studies indicate that laminin 10 plays important roles in wound healing by promoting cell migration, BMZ assembly, reepithelialization, and angiogenesis. This study was supported by grants from NIH/NIAMES, DOD/DARPA and the Dermatology Foundation of South Florida.
Preventive effects of galcanezumab in adult patients with episodic or chronic migraine are persistent: data from the phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2, and REGAIN studies (2018)

Study Identification: EVOLVE-1 (I5Q-MC-CGAG); EVOLVE-2 (I5Q-MC-CGAH); REGAIN (I5Q-MC-CGAI) TRIAL REGISTRATION: ClinicalTrials.gov ; NCT02614183 (EVOLVE-1); NCT02614196 (EVOLVE-2); NCT02614261 (REGAIN).
The third serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type‐II elastase (1998)

Preparations of chymotrypsin from Atlantic cod are heterogeneous and previously gave rise to two active peaks when subjected to pH-gradient chromatography. Extension of the pH-gradient resolved a third protein peak with benzoyltyrosine ethylester hydrolytic activity. The first two peaks have been characterized as chymotrypsin variants and designated A and B, whereas the identity of the third peak was not clear. Analysis of this protein by Edman sequencing and mass spectrometry has now confirmed a high degree of identity with the predicted protein sequence from a recently described cDNA clone. That sequence was named elastase B by sequence comparison. As the present elastase deviates in 16 positions from that of elastase B, we have named it elastase C. The elastase C was active in hydrolysing typical substrates used by chymotrypsin, namely benzoyl-L-tyrosine ethylester and succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, but inactive against the typical elastase substrates succinyl-Ala-Ala-Ala-p-nitroanilide and orcein-elastin. Comparison of the kinetic properties of the cod elastase C with bovine chymotrypsin and cod chymotrypsin variants A and B, using succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, showed a lower catalytic efficiency of elastase C. The effects of several inhibitors on cod elastase C were identical to effects on chymotrypsins variants A and B, but dissimilar when compared with porcine pancreatic elastase. On the basis of the specificity and amino acid sequence, we conclude that the enzyme under study is most correctly classified as a type-II elastase.
MRI Findings from a Case of Fulminating Adult-onset Measles Encephalitis (2006)

We report a rare case of fulminating adult-onset measles encephalitis. A 34-year-old man developed a comatose state after measles eruptions and ultimately akinetic mutism. Titers of anti-measles IgM antibodies were elevated in both serum and cerebrospinal fluid. Brain magnetic resonance imaging (MRI) 3 months after onset revealed widespread hyperintense lesions in the periventricular white matter and marginal hyperintense lesions in the brainstem on fluid-attenuated inversion recovery and diffusion-weighted images. The marginal lesions in the brainstem are similar to subpial demyelinating lesions seen in postinfectious encephalomyelitis. This case of encephalitis may be related to an autoimmune-mediated process triggered by measles infection.
Studies of Filipino patients with systemic lupus erythematosus: Autoantibody profile of first-degree relatives (2010)

This study surveyed the frequency of autoantibodies among un-affected first-degree relatives (FDRs) of Filipino systemic lupus erythematosus (SLE) patients compared with healthy un-related Filipino controls. The sensitivity, specificity and predictive value of the autoantibodies for SLE diagnosis were also assessed in this Filipino cohort. Filipino patients included in the University of Santo Tomas (UST) Lupus Database and un-affected FDRs were recruited. Healthy controls included those with no known personal or family history of autoimmune disease. The following autoantibodies were tested in all subjects: anti-nuclear antibody (ANA), anti-dsDNA, anti-Ro/SSA, anti-chromatin, anti-thyroid microsome, and anti-cardiolipin antibodies. Participants included 232 SLE patients, 546 FDRs, and 221 healthy controls. Median age of patients was 27 (range 8-66) years with median disease duration of 27.5 (range 1-292) months. Median age of FDRs was 42.0 (range 5-87) years. Compared with healthy controls, there were significantly more FDRs with positive ANA at titers 1 : 40 to 1 : 160 (p < 0.001) and 1 : 320 (p = 0.003), anti-Ro/SSA (4.94% versus 0.45%, p = 0.003), and anti-dsDNA ≥ 5.0 IU/ml (4.58% versus 1.36%, p = 0.031). ANA titer ≥1 : 160, anti-dsDNA, anti-Ro/SSA and anti-chromatin had the highest predictive value for SLE diagnosis. These findings reinforce the role of genetic influence in SLE risk among Filipinos, with a significant proportion of un-affected FDRs of SLE patients testing positive for autoantibodies compared with healthy Filipino controls. A longitudinal observational study in this same cohort will determine which proportion of these un-affected FDRs will evolve into clinical SLE disease in the future.
A comparison of thin-plate splines with automatic correspondences and B-splines with uniform grids for multimodal prostate registration (2011)

This paper provides a comparison of spline-based registration methods applied to register interventional Trans Rectal Ultrasound (TRUS) and pre-acquired Magnetic Resonance (MR) prostate images for needle guided prostate biopsy. B-splines and Thin-plate Splines (TPS) are the most prevalent spline-based approaches to achieve deformable registration. Pertaining to the strategic selection of correspondences for the TPS registration, we use an automatic method already proposed in our previous work to generate correspondences in the MR and US prostate images. The method exploits the prostate geometry with the principal components of the segmented prostate as the underlying framework and involves a triangulation approach. The correspondences are generated with successive refinements and Normalized Mutual Information (NMI) is employed to determine the optimal number of correspondences required to achieve TPS registration. B-spline registration with successive grid refinements are consecutively applied for a significant comparison of the impact of the strategically chosen correspondences on the TPS registration against the uniform B-spline control grids. The experimental results are validated on 4 patient datasets. Dice Similarity Coefficient (DSC) is used as a measure of the registration accuracy. Average DSC values of 0.97&plusmn;0.01 and 0.95&plusmn;0.03 are achieved for the TPS and B-spline registrations respectively. B-spline registration is observed to be more computationally expensive than the TPS registration with average execution times of 128.09 &plusmn; 21.7 seconds and 62.83 &plusmn; 32.77 seconds respectively for images with maximum width of 264 pixels and a maximum height of 211 pixels.
Scaffolded amino acids as a close structural mimic of type-3 copper binding sites (2007)

We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase.
Distributed Impedance Models (2012)

This chapter contains sections titled: Distributed RBULK|CBULK – RINT|CPEDL Circuit Model General Impedance Models for Distributed Electrode Processes Identification of Frequency Ranges for Conductivity and Permittivity Measurements
Kinetic study of the alkaline degradation of imidapril hydrochloride using a validated stability indicating HPLC method (2016)

An aqueous alkaline degradation study was performed for imidapril hydrochloride (IMD) drug in the presence of its degradation products and an isocratic stability indicating method was presented using HPLC.
Fuel Cell APU for Silent Watch and Mild Electrification of a Medium Tactical Truck (2004)

&lt;div class="htmlview paragraph"&gt;This paper investigates the opportunities for improving truck fuel economy through the use of a Fuel Cell Auxiliary Power Unit (FC APU) for silent watch, as well as for powering electrified engine accessories during driving. The particular vehicle selected as the platform for this study is a prototype of the Family of Medium Tactical Vehicles (FMTV) capable of carrying a 5 ton payload. Peak stand-by power requirements for on-board power are determined from the projected future digitized battlefield vehicle requirements. Strategic selection of electrified engine accessories enables engine shutdowns when the vehicle is stopped, thus providing additional fuel savings. Proton Exchange Membrane (PEM) fuel cell is integrated with a partial oxidation reformer in order to allow the use of the same fuel (JP8) as for the propulsion diesel engine. The APU system is modeled and linked with the complete vehicle system simulation, and accessory duty cycles are derived for both silent watch and driving. The results indicate six-fold improvements of the silent watch fuel economy with the FC APU compared to main-engine idling, and relatively modest improvements from the mild electrification and FC APU use during the driving cycle. Combined fuel economy benefits calculated over the hypothetical daily military mission with a combined 10 hour highway/local/off-road driving and 10 hour silent watch are 20.1%.&lt;/div&gt;