gebhart/patrepeval huggingface dataset:
Automatic C to Simulink Model Converter (C2M) Tool (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The automotive industry today follows Model Based Development (MBD) for developing modern automotive applications. This method involves creating models for a system under design and then using tools like MATLAB/Simulink to auto-generate code for target platforms. This method is popular since maintenance of MBD based applications is simple and less time consuming as compared to maintaining hand-written application code. Thus, MBD facilitates correct designs and easy maintenance of automotive applications. However, there are legacy automotive applications that are not developed using models. It is difficult to accommodate and test any changes in such application codes since it requires extensive testing. Additionally, for application code generated from models, many a times, code is changed during testing and these changes are not reflected in the model. Hence, there is a need to convert legacy automotive application codes to models. A novel Code to Model (C2M) tool is described in the paper that can automatically convert a given code to Simulink model. We also discuss the design and few implementation challenges of this tool. The C2M tool has been tested with an automotive powertrain code. It has resulted in near 100% productivity improvement with respect to the conversion process while adhering to the MathWorks Automotive Advisory Board (MAAB) guidelines and has 95% accurate conversion rate.&lt;/div&gt;&lt;/div&gt;
Variable length genomes for evolutionary algorithms (2000)

A general variable length genome, called exG, is developed here to address the problems of fixed length representations in canonical evolutionary algorithms. Convergence aspects of exG are discussed and preliminary results of exG usage are presented. The generality of this variable legnth genome is also shown via comparisons with other variable length representations. 1
Cronobacter sakazakii DNA Detection in Cerebrospinal Fluid of a Patient with Amyotrophic Lateral Sclerosis Mimic Syndrome (2015)

A 45-year-old male noticed progressive weakness of the right lower limb with gait disturbance. Over the following months, motor deficits worsened, spreading to the right upper limb. Electromyography showed active denervation in the upper and lower limb muscles. A diagnosis of amyotrophic lateral sclerosis (ALS) was made. About 2 years after symptom onset, gradual improvement occurred. Cerebrospinal fluid analysis performed about 3 years after the beginning of symptoms identified Cronobacter sakazakii. Since no other possible causes were identified, we suggest that an almost completely reversible ALS-like syndrome had been triggered by Cronobacter infection in our immunocompetent patient.
Cost of decentralized CAR T‐cell production in an academic nonprofit setting (2020)

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries are exploring alternative T-cell production modes. Our study is based on the T-cell production experience in a nonprofit setting in Germany. We first identified the work steps and main activities in the production process. Then we determined the fixed costs and variable costs. Main cost components included personnel and technician salaries, expenditure on equipment, a clean room, as well as production materials. All costs were calculated in 2018 euros and converted into U.S. dollars. For a clean room with one machine for closed and automated manufacturing installed, annual fixed costs summed up to approximately €438 098 ($584 131). The variable cost per production was roughly €34 798 ($46 397). At the maximum capacity of one machine, total cost per product would be close to €60 000 ($78 849). As shown in the scenario analysis, if three machines were to be installed in the clean room, per production cost could be as low as €45 000 (roughly $59905). If a cheaper alternative to lentivirus was used, per production total cost could be further reduced to approximately €33 000 (roughly $44309). Decentralized T-cell production might be a less costly and more efficient alternative to the current centralized production mode that requires a high acquisition cost.
Identification and characterization of a surface-exposed, 66-kilodalton protein from Borrelia burgdorferi (1995)

The surface-exposed antigens of Borrelia burgdorferi represent important targets for the development of a protective immune response. We have identified a proteinase K-accessible, 66-kDa protein from B. burgdorferi and have demonstrated that at least a portion of this protein is surface exposed. The 66-kDa protein was purified by sequential extraction of spirochetes with butanol and Triton X-114 followed by preparative gel electrophoresis. Polyclonal antibodies developed against the purified 66-kDa protein were Borrelia spp. specific, whereas a monoclonal antibody, Route 66, displayed a genospecies-specific pattern of recognition for the 66-kDa protein. N-terminal amino acid sequence was obtained from an internal fragment, a truncated version, and the full-length form of the 66-kDa protein. A search of protein and gene databases for homologous sequences yielded a match with the predicted amino acid sequence from a segment of B. burgdorferi chromosomal DNA (P. A. Rosa, D. Hogan, and T. G. Schwan, J. Clin. Microbiol. 29:524-532, 1991). The construction of primers based on this DNA sequence and the N-terminal amino acid sequence allowed the amplification and cloning of the 66-kDa-protein gene. The identity of the cloned gene was verified by the recognition of the expressed gene product by Route 66. Pulsed-field gel electrophoresis and Southern blot analysis were performed to confirm the chromosomal location of the 66-kDa-protein gene. This study describes the identification and cloning of the first chromosomally encoded, surface-exposed protein from B. burgdoferi.
On the ‘‘band-A’’ emission and boron related luminescence in diamond (1992)

Cathodoluminescence spectra of undoped and boron-doped diamond films are reported and are compared with each other. The dominant spectra feature of these samples is the broad luminescence bands centered around 2.83 and 2.32 eV in undoped and relatively heavily doped samples, respectively. Our result indicates that the commonly observed 2.83 eV band (often called by the name ‘‘band-A’’) is neither related to boron nor to donor-acceptor pairs in diamond. From all of the available data, we conclude that the 2.32 eV band is due to boron related centers and the 2.83 eV band is due to dislocations in diamond.
Ring expansion with four C atoms by tandem (2 + 2)cycloaddition and electrocyclic ring opening (1985)

A four-carbon ring expansion is presented which involves reaction of enamines of cyclic ketones with methyl propiolate followed by reaction of the resulting cis,cis-cycloalkadienes, also containing an ‘enamine’ type of double bond, with dimethyl acetylenediacarboxylate (DMAD).
Evaluation of the Associations Between the Single Nucleotide Polymorphisms of the Promoter Region of the Tumor Necrosis Factor-α Gene and Nasopharyngeal Carcinoma (2006)

Allelic variants of the TNF-alpha promoter gene may not be used as biomarkers of susceptibility to NPC. The role of the -806T allele needs to be studied further.
A Lysosomal Lair for a Pathogenic Protein Pair (2011)

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. Although many of the causes of PD remain unclear, a consistent finding is the abnormal accumulation of the protein α-synuclein. In a recent issue of Cell, Mazzuli et al. provide a molecular explanation for the unexpected link between PD and Gaucher's disease, a glycolipid lysosomal storage disorder caused by loss of the enzyme glucocerebrosidase (GBA). They report a reciprocal connection between loss of GBA activity and the accumulation of α-synuclein in lysosomes that establishes a bidirectional positive feedback loop with pathogenic consequences. Understanding how lysosomes are implicated in PD may reveal new therapeutic targets for treating this disease.
Surface Engineered Doping of Hematite Nanorod Arrays for Improved Photoelectrochemical Water Splitting (2014)

Given the narrow band gap enabling excellent optical absorption, increased charge carrier density and accelerated surface oxidation reaction kinetics become the key points for improved photoelectrochemical performances for water splitting over hematite (α-Fe2O3) photoanodes. In this study, a facile and inexpensive method was demonstrated to develop core/shell structured α-Fe2O3 nanorod arrays. A thin, Ag-doped overlayer of ~2-3 nm thickness was formed along α-Fe2O3 nanorods via ultrasonication treatment of solution-based β-FeOOH nanorods in Ag precursor solution followed by high temperature annealing. The obtained α-Fe2O3/AgxFe2-xO3 core/shell nanorod films demonstrated much higher photoelectrochemical performances as photoanodes than the pristine α-Fe2O3 nanorod film, especially in the visible light region; the incident photon-to-current efficiency (IPCE) at 400 nm was increased from 2.2% to 8.4% at 1.23 V vs. RHE (Reversible hydrogen electrode). Mott-Schottky analysis and X-ray absorption spectra revealed that the Ag-doped overlayer not only increased the carrier density in the near-surface region but also accelerated the surface oxidation reaction kinetics, synergistically contributing to the improved photoelectrochemical performances. These findings provide guidance for the design and optimization of nanostructured photoelectrodes for efficient solar water splitting.
Untangling the web from DNS (2004)

The Web relies on the Domain Name System (DNS) to resolve the hostname portion of URLs into IP addresses. This marriage-of-convenience enabled the Web&amp;apos;s meteoric rise, but the resulting entanglement is now hindering both infrastructures---the Web is overly constrained by the limitations of DNS, and DNS is unduly burdened by the demands of the Web. There has been much commentary on this sad state-of-affairs, but dissolving the ill-fated union between DNS and the Web requires a new way to resolve Web references. To this end, this paper describes the design and implementation of Semantic Free Referencing (SFR), a reference resolution infrastructure based on distributed hash tables (DHTs).
The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review (2017)

Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell. Different chemopreventative approaches have been sought to interfere with initiation and control malignant progression. Here we present research on dietary compounds with evidence of cancer prevention activity that highlights the potential beneficial effect of a diet rich in cruciferous vegetables. The Brassica family of cruciferous vegetables such as broccoli is a rich source of glucosinolates, which are metabolized to isothiocyanate compounds. Amongst a number of related variants of isothiocyanates, sulforaphane (SFN) has surfaced as a particularly potent chemopreventive agent based on its ability to target multiple mechanisms within the cell to control carcinogenesis. Anti-inflammatory, pro-apoptotic and modulation of histones are some of the more important and known mechanisms by which SFN exerts chemoprevention. The effect of SFN on cancer stem cells is another area of interest that has been explored in recent years and may contribute to its chemopreventive properties. In this paper, we briefly review structure, pharmacology and preclinical studies highlighting chemopreventive effects of SFN.
Learning from litigation. The role of claims analysis in patient safety (2006)

Claims for malpractice and medical negligence are a potentially important source of information on the causes of harm to patients and have provided valuable lessons in the past. However today, with many additional sources of information and methods of analysis, the role of claims analysis needs to be reappraised. We consider the role of claims analysis in relation to other methods of studying adverse outcomes, review previous studies of claims and summarize the findings of four recent British specialty claims reviews. Claims analysis has a number of inherent limitations. We suggest that there is now no case for ad hoc claims reviews which rely on data that have been assembled for legal purposes only. Claims review is still potentially useful for rare events or in cases where other sources of data are not available. However, future claims reviews need to meet basic criteria before being undertaken; these include prospective identification of the relevant questions and variables, adequacy and completeness of the data set, availability of expert reviewers and clear protocols for review.
ChemInform Abstract: Characterization of New Infrared Nonlinear Optical Material with High Laser Damage Threshold, Li2Ga2GeS6. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Survey of In-Car Jammers - Analysis and Modeling of the RF Signals and IF Samples (Suitable for Active Signal Cancelation) (2011)

Innovative distance based charging (DBC) systems for road user charging (RUC) or pay-as-you-drive insurances charge their users on the mileage recorded. The primary sensor therefore is GNSS. GNSS allows the charging system a high degree of flexibility, but is also very vulnerable due to its low signal power. It is the weakest point of the charging system, which can be target for possible fraud attempts. This brings so called in-car jammers in place. In-car jammers are small devices, powered from the cigarette lighter of a car, transmitting a high power signal within the GNSS frequency band. Thereby, they are blocking the signal reception not only in the targeted GNSS receiver, but also in its vicinity and degrading the position determination, proportional to the distance, over a wide area. To understand how serious the real threat of these jammers is, seven devices were analyzed in the frequency and time domain. With this knowledge, mathematical models are derived, which support the development of mitigation technologies. Finally, a novel mitigation approach called “Active Signal Cancellation” will be introduced.
Differential Regulation of the Secretions of Matrix Metalloproteinase‐9 and Tissue Inhibitor of Metalloproteinases‐1 from Human Keratinocytes in Culture (2000)

To investigate the pathophysiological roles of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinases (TIMP)-1 in the differentiation of keratinocytes, we used human keratinocytes in culture to examine the gelatinolytic activity of MMP-2 and MMP-9 by zymographic analysis, MMP-9 mRNA by reverse transcriptase-polymerase chain reaction, and TIMP-1 mRNA by Northern blot analysis. Adding of calcium (1 mM) to the culture medium increased the activity of MMP-9 and MMP-9 mRNA without affecting MMP-2 activity or the expression of TIMP-1 mRNA. These results suggest that keratinocytes regulate the expressions of MMP-9 and TIMP-1 differently during the process of differentiation.
The nature of CuA in cytochrome c oxidase (1989)

Kroneck et al. [(1988) FEBS Lett. 242, 70-74] have recently suggested, on the basis of a comparison with the EPR properties of nitrous oxide reductase, that cytochrome c oxidase contains a mixed-valence binuclear copper site, and that this is responsible for the EPR spectrum generally ascribed to CuA. Here we question this hypothesis in view of a multitude of analytical and spectroscopic data available. We maintain that a mononuclear Cu site with two cysteine sulfur and two imidazole nitrogen atoms as ligands is consistent with the current experimental information on the CuA site.
INVESTIGATIONS ON CODEPOSITED ALUMINUM–TIN SYSTEMS WITH SIMS (2001)

Sputter deposited coatings of immiscible two-component systems as aluminum–tin are used for automotive applications as plain bearings to obtain longer lifetimes for high performance diesel engines. In the manufacturing process many parameters as temperature, deposition rate, deposition time or element ratio can be varied. In an experimental two target sputter plant coatings have been produced at different temperatures, especially one near the melting point of Sn, by applying a codeposition technique. The structures and the distributions of Al and Sn in these coatings have been investigated with secondary Ion mass spectroscopy (SIMS).
Efficient TLM sensitivity analysis exploiting rubber cells (2008)

The Adjoint Variable Method (AVM) is applied for the first time to perform sensitivity analysis for Transmission Line Modeling (TLM) using rubber cells with modified tensor properties. Rubber cells allow the conformal modeling of off-grid boundaries in the TLM domain using modified tensor properties. The scattering matrix of the rubber cell is analytically dependent on the dimensions of the modeled discontinuities. Using this property, an exact adjoint system is derived. The original and adjoint systems supply the necessary field information for the rubber cell based sensitivity calculations. Our technique is illustrated through sensitivity analysis and optimization of a waveguide bandpass filter.
Solute-Solvent Interactions in Discotic Mesophases (1979)

Abstract A 1:l mixture of benzenehexa-n-heptanoate and benzenehexa-n-octanoate is used as a solvent for small nonmesogenic molecules. As opposed to the general expectation of depressions of phase transition temperatures by solute, enhancement, decreases, and maxima as a function of solute concentration are seen. Enthalpic changes parallel the transition temperature changes. Rod-disc interactions are also discussed.
Improved Detection of the Sickle Mutation by DNA Analysis (1982)

DETECTION of sickle hemoglobin in the human fetus was first accomplished nearly 10 years ago.1 , 2 This marked the beginning of a technology for prenatal diagnosis of the hemoglobinopathies. When methods for acquisition of fetal blood and for analysis of globin-chain synthesis were developed, the prenatal diagnosis of sickle-cell anemia and the thalassemia syndromes became a practical reality.3 , 4 Nearly 2000 fetuses at risk for these disorders have now been studied worldwide.5 However, a fetal loss of about 5 per cent due to these invasive procedures has provided the impetus for the development of diagnostic approaches that use fetal DNA rather than . . .
Role of cannabinoids in chronic liver diseases (2008)

Cannabinoids are a group of compounds acting primarily via CB1 and CB2 receptors. The expression of cannabinoid receptors in normal liver is low or absent. However, many reports have proven up-regulation of the expression of CB1 and CB2 receptors in hepatic myofibroblasts and vascular endothelial cells, as well as increased concentration of endocannabinoids in liver in the course of chronic progressive liver diseases. It has been shown that CB1 receptor signalling exerts profibrogenic and proinflammatory effects in liver tissue, primarily due to the stimulation of hepatic stellate cells, whereas the activation of CB2 receptors inhibits or even reverses liver fibrogenesis. Similarly, CB1 receptor stimulation contributes to progression of liver steatosis. In end-stage liver disease, the endocannabinoid system has been shown to contribute to hepatic encephalopathy and vascular effects, such as portal hypertension, splanchnic vasodilatation, relative peripheral hypotension and probably cirrhotic cardiomyopathy. So far, available evidence is based on cellular cultures or animal models. Clinical data on the effects of cannabinoids in chronic liver diseases are limited. However, recent studies have shown the contribution of cannabis smoking to the progression of liver fibrosis and steatosis. Moreover, controlling CB1 or CB2 signalling appears to be an attractive target in managing liver diseases.
La ville et le sport : autour du Projet sportif territorial de Brest (2016)

International audience
Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana (2018)

A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC<sub>50</sub>s 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).
Molecular analysis of the first avian influenza H5N1 isolates from fowl in Romania. (2008)

Since the events of avian influenza (AI) caused by H5N1 subtype from Hong Kong (1997), the people worldwide have been confronted with new waves of epizootic influenza. In 2005 in Romania an unprecedent H5N1 epizootic occurred in domestic and wild birds. Therefore an immediate investigation by molecular approach of this highly pathogenic H5N1 strain was necessary. The virus isolation and the RNA extraction were performed in the Institute of Diagnosis and Animal Health while PCR and sequencing were carried out in Cantacuzino Institute. Herein we report the first evidence of H5N1 presence in Romanian fowls. The phylogenetic analysis of haemagglutinin and neuraminidase gene indicated a close relationship of Romanian strains to those from Siberia and China. The virological and molecular analysis of the first strains of avian virus from Romania confirmed the presence of H5N1 subtype, belonging to the genetic line Z. These results indicate that the avian virus from this genetic line is directly derived from the highly pathogenic viruses isolated in China and Russia in 2005.
Nonlinear effects in ultrasmall silicon-on-insulator ring resonators (2006)

We investigate the significance of secondary effects caused by free carrier accumulation and subsequent heating on the nonlinear behaviour of ultrasmall Silicon-On-Insulator ring resonators. All-optical bistability based on thermal dispersion was experimentally obtained for an input power of only 0.28mW. At higher powers, pulsating behaviour was observed which is problematic for the stability of thermal memory and switching operations. Using free carrier dispersion, we also demonstrate all-optical wavelength conversion with a pulse length of 10 ns, indicating that bitrates of 0.1 Gb/s are feasible. Also here, the presence of unstable pulsations was observed, leading to significant errors in the converted data pattern.
Phase 2 Study of Intralesional PV-10 in Refractory Metastatic Melanoma (2014)

Intralesional PV-10 yielded durable local control with high rates of complete response. Toxicity was confined predominantly to the injection site. Cutaneous bystander tumor regression is consistent with an immunologic response secondary to ablation. This intralesional approach for local disease control could be complementary to current and investigational treatments for melanoma.