gebhart/patrepeval huggingface dataset:
Trisannelated Benzenes by Cyclotrimerization of Bromostannylalkenes (1997)

Up to 80% yields of cyclotrimers, including 2 depicted below, can be achieved by reaction of bromo(stannyl)alkenes such as 1 with Cu(NO3)2 · 3H2O at room temperature in THF. This route, a definite improvement over previously reported methods, makes such molecules available in sufficient quantity for study, for example, as precursors of fullerene fragments.
Ceramide-based lipid profiles and the prevalence of type 2 diabetes differ between patients with coronary artery disease and those with peripheral artery disease (2022)

Abstract Introduction Serum lipids and metabolic diseases, in particular type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), predict the atherosclerotic diseases coronary artery disease (CAD) and peripheral arterial disease (PAD). Purpose The purpose of this study was to investigate in how far a more detailed characterization including serum lipids improves discrimination of PAD from CAD. Method A cohort of 274 statin-naïve patients with either PAD (n=89) or stable CAD (n=185) were referred to metabolic screening and were characterized using nuclear magnetic resonance- and liquid chromatography-tandem mass spectrometry based advanced lipid and lipoprotein analysis. Results were validated in an independent cohort of 1239 patients with PAD or CAD. Results We found a significant difference in T2D prevalence and in the ceramide-based lipid profile between PAD and CAD patients. However, neither cholesterol-based markers (including LDL-C, HDL-C) and detailed lipoprotein profiles nor the LD status differed significantly between PAD and CAD patients (figure). The difference between ceramide-based lipid profiles of CAD and PAD remained significant also after adjusting for body composition, smoking, inflammatory parameters, and T2D. Conclusion We conclude that PAD and CAD differ in ceramide-based lipid profiles and T2D status, but not in other lipid characteristics or metabolic diseases. Funding Acknowledgement Type of funding sources: None.
Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review (2017)

Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite <i>Echinococcus granulosus</i> (<i>E. granulosus</i>). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity. In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of <i>E. granulosus</i> infection in man. The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect <i>E. granulosus</i> from elimination and to minimize host severe pathology. Understanding the immune mechanisms of <i>E. granulosus</i> infection in an intermediate human host will provide, we believe, a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections. Besides that, the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides. More studies for the better understanding of the mechanisms of parasite immune evasion is necessary. It will enable a novel approach in protection, detection and improving of the host inflammatory responses. In contrast, according to the "hygiene hypothesis", clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergic and autoimmune diseases. Thus, an understanding of the immune mechanisms of <i>E. granulosus</i> infection is extremely important.
Characterization of a secondary uptake system for l-glutamate inCorynebacterium glutamicum (1996)

A new transport system for the uptake of l-glutamate was characterized in Corynebacterium glutamicum strain Δglu, in which the previously described binding protein-dependent glutamate uptake system is not present. Kinetic characterization revealed a highly specific secondary transport system, dependent on sodium ions. Glutamate uptake showed Michaelis-Menten kinetics, with a Km of 0.6 mM and a Vmax of 15 nmol min−1 (mg dw)−1. For the co-transported sodium ions, a relatively low Km of 3.3 mM was determined.
On-Plate Electrochemical Detection for Thin-Layer Chromatography (1989)

Abstract Voltammetric electrochemical detection (ECD) coupled with thin-layer chromatography (TLC) was demonstrated for the quantification of trace organic compounds directly on a TLC plate. the electrochemical detection solvent was a thin layer of aqueous potassium chloride. For undeveloped plates, detection limits for p-anisidine and p-phenetidine were 10 ng and 13 ng, respectively. Linearity was demonstrated over nearly 2 orders of magnitude. After development, detection limits increased by approximately a factor of ten. Advantages of this method over other quantitative TLC methods include sensitivity, speed, simplicity, and cost. in addition, this method is selective for electrochemically active compounds. Major sources of experimental error include spot size reproducibility, working electrode placement, and supporting electrolyte film thickness.
A polymorphic 15GHz/mW inductorless frequency prescaler using implication logic in 0.13&#x03BC;m CMOS (2012)

This paper describes a power-efficient frequency prescaler operating at maximum frequency of 12.3GHz without using inductors. A novel logic concept and reconfigurable technique is presented to achieve two division factors by using just one single-phase clock flip-flop. The prescaler is implemented in 0.13μm CMOS technology. It occupies 14×12μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 817μW at maximum frequency. Experimental results indicate a power efficient and compact frequency divider working in wide frequency range from 5GHz to 12.3GHz.
ChemInform Abstract: A NOVEL METHOD FOR HETEROATOM‐SUBSTITUTED FREE RADICAL GENERATION BY PHOTOCHEMICAL ELECTRON TRANSFER INDUCED DESILYLATION OF RXCH2SIME3 SYSTEMS (1985)

Abstract Lösungen der Ether bzw. Thioether (II) mit dem Pyrroliniumsalz (I) weisen konkurrierend zur Fluoreszenzlöschung einen reversiblen Elektronentransfer auf, der nach vorangehender Desilylierung zur regioselektiven Bildung der Photoaddukte (III) führt.
AccuRate: constellation based rate estimation in wireless networks (2010)

This paper proposes to exploit physical layer information towards improved rate selection in wireless networks. While existing schemes pick good transmission rates, this paper takes a step further towards computing the optimal bit rate. The main idea is to capture the channel behavior through symbol level dispersions, and replay these dispersions on different rate encodings of the same packet. The replay action can be emulated at the receiver without requiring the transmitter to send the packet at every other rate. The maximum successful rate is likely to be the optimal rate of the received packet, and assuming that the channel remains coherent, the same rate can be prescribed for the next transmission. We design, implement, and evaluate this idea over a small testbed of USRP hardware and GNURadio software. Our proposal, called AccuRate, predicts a packet's optimal rate 95% of times when the packet is received correctly. When the packet is received in error, AccuRate computes its optimal rate with 93% accuracy. In terms of throughput, we show that AccuRate improves over the state-of-the-art scheme SoftRate by around 10%, and is reasonably close to the optimal.
Contact principle and the realization on the 5 axis - NC machining tool (2003)

2003-2004 > Academic research: refereed > Publication in refereed journal
Bacterial contamination hypothesis: a new concept in endometriosis (2018)

For the first time, a new concept called the "bacterial contamination hypothesis" is proposed in endometriosis. This study's findings of IUMC in women with endometriosis could hold new therapeutic potential in addition to the conventional estrogen-suppressing agent.
Hydrogenation of alkynyl ketones catalyzed by tetrabutylammonium bromide (2022)

<p indent="0mm">Propargyl alcohol compounds have many applications in medicine, pesticides and functional molecular materials, and are also important intermediates in organic synthesis because they contain alkynyl and hydroxyl groups in the molecules. The common preparation methods for propargyl alcohol usually rely on the transition metal catalyzed hydrogenation reaction and the alkynylation of ketones, which is high cost and with poor tolerance of the substitution groups. In this article, the hydrogenation reaction of alkynyl ketones with pinacolborane was developed with tetrabutylammonium bromide as catalyst. The present method provided a convenient, economical and efficient method for the synthesis of propargyl alcohol compounds.
Supplementary Figures 1-4 from Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and Tumorigenesis (2023)

Supplementary Figures 1-4 from Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and Tumorigenesis
Compressed sensing based cone‐beam computed tomography reconstruction with a first‐order methoda) (2010)

It is demonstrated that compressed sensing outperforms the traditional algorithm when dealing with sparse, and potentially noisy, CBCT projection views.
Effekt einer extrakorporalen sFlt-1-Apherese auf die maternale Nierenfunktion bei Präeklampsie (2013)

Einleitung: Eine Dysbalance zwischen angiogenen (placental growth factor = PlGF) und anti-angiogenen Faktoren (soluble fms-like tyrosine kinase 1 = sFlt1) ist heute als entscheidender pathogenetischer Faktor für die Entstehung der Präeklampsie (PE) akzeptiert. Eine extrakorporale sFlt-1-Apherese ist eine innovative Methode, durch serielle Reduktion der maternalen sFlt-1-Konzentration die Schwangerschaft zu stabilisieren. Ziel dieser Untersuchung ist zu analysieren, wie eine Abnahme der sFlt-1-Konzentration die nichtspezifische Proteinurie beeinflusst.
Energy–saving & Membrane Fouling Control for MBR Technology (2015)

The market of MBR spreads and is strengthening the position as the social infrastructure technology. Several plans have been made for MBR with a treatment capacity of more than 10,000 m3/d also in Japan. This is owing to cost reduction in MBR membranes and reduction in energy consumption, which is the biggest challenge for the spread of MBR market. The major factor influencing on energy consumption is membrane fouling. Fouling can be suppressed by increasing the amount of air for cleaning on the membrane surface, but it will increase energy consumption. Therefore, it is important to control both energy consumption and membrane fouling. As a result of R&D in Japan, the value of energy consumption has become close to that of conventional process. It is expected that the former will become equal to or less than the latter in the near future. Various membrane fouling control methods have also been developed, the adoption of them being expected in large–scale MBR plants.
Strawberry Cultivar Use in North America (2000)

Strawberry ( Fragaria × ananassa Duch.) cultivars used by commercial producers in North America often change rapidly due to several factors including modified cultural practices, processing and marketing practices, the desire for new cultivars with larger and higher quality berries, resistant insect and disease pests, loss of traditional chemical control methods, and private sector breeding programs. Within the past decade, the annual plastic-mulched production system has quickly expanded into eastern North America prompting the need for cold-hardy cultivars adapted to that system. The continuing loss of traditional chemical controls for strawberry insects and diseases, including the impending loss of methyl bromide, has prompted the need for increased insect and disease resistance. In addition, consumer demands for a healthier food product with lower chemical residues has heightened this need. Small fruit experts from across North America provided information on the primary strawberry cultivars used in the recent past, the present, and potential cultivars for the future, as well as on current strawberry acreage in their respective states and provinces.
Picosecond Time-Resolved Absorption Dynamics in the Artificial Bacteriorhodopsin Pigment BR6.9 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPicosecond Time-Resolved Absorption Dynamics in the Artificial Bacteriorhodopsin Pigment BR6.9J. K. Delaney, G. H. Atkinson, M. Sheves, and M. OttolenghiCite this: J. Phys. Chem. 1995, 99, 19, 7801–7805Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/j100019a069https://doi.org/10.1021/j100019a069research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Spotted the Site? (2000)

A free e-mail Legionella newsletter (about once a
Contact lens management of keratoconus (2015)

Contact lenses are the primary form of visual correction for patients with keratoconus. Contemporary advances in contact lens designs and materials have significantly expanded the available fitting options for patients with corneal ectasia. Furthermore, imaging technology, such as corneal topography and anterior segment optical coherence tomography, can be applied to both gain insight into corneal microstructural changes and to guide contact lens fitting. This paper provides a comprehensive review of the range of contact lens modalities, including soft lenses, hybrid designs, rigid lenses, piggyback configurations, corneo-scleral, mini-scleral and scleral lenses that are currently available for the optical management of keratoconus. The review also discusses the importance of monitoring for disease progression in patients with keratoconus, in particular children, who tend to undergo more rapid progressive changes, so as to facilitate appropriate modification to contact lens fitting and/or potential referral for corneal collagen cross-linking treatment, as appropriate.
Progress on the Coupling Coil for the Mice Channel (2006)

This report describes the progress on the coupling magnet for the international Muon Ionization Cooling Experiment (MICE). MICE consists of two cells of a SFOFO cooling channel that is similar to that studied in the level 2 study of a neutrino factory. The MICE RF coupling coil module (RFCC module) consists of a 1.56 m diameter superconducting solenoid, mounted around four cells of conventional 201.25 MHz closed RF cavities. This report discusses the progress that has been made on the superconducting coupling coil that is around the center of the RF coupling module. This report describes the process by which one would cool the coupling coil using a single small 4 K cooler. In addition, the coupling magnet power system and quench protection system are also described.
ChemInform Abstract: Catalytic Enantioselective Conjugate Allylation of Unsaturated Methylidene Ketones. (2011)

Abstract The reaction tolerates aromatic and aliphatic substituents.
N-(Ferrocenylmethyl)-N-methylaminocyclotriphosphazenes (2001)

The reactions of N-(ferrocenylmethyl)-N-methylamine, C(5)H(5)FeC(5)H(4)CH(2)(Me)NH, with hexachlorocyclotriphosphazene, N(3)P(3)Cl(6), led to the formation of the N-(ferrocenylmethyl)-N-methylaminocyclotriphosphazene derivatives, N(3)(-)P(3)Cl(6-n)[N(Me)CH(2)C(5)H(4)FeC(5)H(5)](n) (n = 1-3). Only small amounts of higher degrees of substitution could be detected. In the case of the disubstituted products, the ratio of isomers was dependent on the polarity of the solvent. In nonpolar solvents the ratio was trans > geminal > cis while in acetonitrile only equal amounts of trans and cis isomers were observed. The reaction of N-(ferrocenylmethyl)-N-methylamine with (methacryloylbutenedioxy)pentachlorocyclotriphosphazene, N(3)P(3)Cl(5)O(CH(2))(4)OC(O)C(Me)=CH(2), gives the surprising geminal isomer 2,2-N(3)P(3)Cl(4)[O(CH(2))(4)OC(O)C(Me)=CH(2)]N(Me)CH(2)C(5)H(4)FeC(5)H(5) and the tris derivative 2,2',4-N(3)P(3)Cl(3)[O(CH(2))(4)OC(O)C(Me)=CH(2)][N(Me)CH(2)C(5)H(4)FeC(5)H(5)](2). All of the phosphazene derivatives were characterized by elemental analyses, mass spectrometry, IR and NMR ((1)H, (13)C, (31)P) spectroscopy, and electrochemical techniques (cyclic, normal pulse, and differential pulse voltametry). The compounds all undergo a single, reversible oxidation reduction process.
Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats (2019)

The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure contains ~80% corticotropin-releasing factor (CRF) neurons and that the optogenetic inactivation of these CeA CRF+ neurons prevents recruitment of the neuronal ensemble, decreases the escalation of alcohol drinking, and decreases the intensity of somatic signs of withdrawal. Optogenetic dissection of the downstream neuronal pathways demonstrates that the reversal of addiction-like behaviors is observed after the inhibition of CeA CRF projections to the bed nucleus of the stria terminalis (BNST) and that inhibition of the CRF<sup>CeA-BNST</sup> pathway is mediated by inhibition of the CRF-CRF<sub>1</sub> system and inhibition of BNST cell firing. These results suggest that the CRF<sup>CeA-BNST</sup> pathway could be targeted for the treatment of excessive drinking in alcohol use disorder.
Abstract B010: Antitumor cellular immune response elicited by Toca 511 and Toca FC therapy in preclinical and clinical studies (2018)

Abstract Toca 511 (vocimagene amiretrorepvec), in combination with Toca FC (5-FC; flucytosine extended-release tablets), is an investigational combination product currently under development for the treatment of high-grade glioma (HGG) and other solid tumors. Toca 511 is a gamma-retroviral replicating vector (RRV) delivering a cytosine deaminase transgene to infected cells to convert antifungal drug 5-fluorocytosine (5-FC) into antineoplastic drug 5-fluorouracil (5-FU). Toca 511 can be administered by multiple routes; selectively infects, spreads, and persists in cancer cells; and through multiple mechanisms of action can elicit an antitumor immune response. Treatment directly kills infected cancer cells. Diffusible 5-FU also kills neighboring susceptible cells that contribute to the immune-suppressed tumor microenvironment, especially myeloid immune suppressor cells. After multiple cycles of 5-FC, treated animals that clear tumor are resistant to tumor rechallenge. Adoptive transfer recipients of splenocytes from animals that previously cleared their tumor through treatment with Toca 511 and 5-FC experience a significant survival benefit compared to animals receiving spleen cells from naïve donors. Toca 511 and Toca FC have been administered to 126 recurrent high-grade glioma (rHGG) patients in three phase I studies (NCT01156584, NCT01470794, NCT01985256), and a phase 2/3 trial (Toca 5) is ongoing (NCT02414165). Toca 511 plus Toca FC has been well tolerated in these patients. In the clinical study presented, Toca 511 is injected into resection cavity walls at time of tumor resection, and followed with multiple courses of Toca FC. In a subset of phase I patients that mimic the phase 2/3 rHGG enrollment criteria, there were 3 complete responses and 2 partial responses out of 24 patients observed. The median duration of response is 26.7 months. These responders have an overall survival range from 24.0+ to 42.6+ months and ongoing. Data are consistent with induction of antitumor immune responses after Toca FC administration. Changes in peripheral immune populations as well as interrogation of immunogenic biomarkers in responding compared to nonresponding patients will be presented. Citation Format: Tiffany T. Montellano, Derek Ostertag, Daniel J. Hogan, Oscar R. Diago, Dawn Gammon, Ali Haghighi, William Accomando, Leah Mitchell, Asha Das, Harry Gruber, Douglas J. Jolly. Antitumor cellular immune response elicited by Toca 511 and Toca FC therapy in preclinical and clinical studies [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B010.
Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors (2021)

The Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein we report novel NHE-1 inhibitors realized via functionalization of N<sup>1</sup>-alkyl quinazoline-2,4(1H,3H)-dione and quinazoline-4(3H)-one with N-acylguanidine or 3-acyl(5-amino-1,2,4-triazole) side chain. Lead compounds show activity in a nanomolar range. Their pharmacophoric features were elucidated with neural network modeling. Several compounds combine NHE-1 inhibition with antiplatelet activity. Compound 6b reduces intraocular pressure in rats and effectively inhibits the formation of glycated proteins. Compounds 3e and 3i inhibit pro-inflammatory activation of murine macrophages, LPS-induced interleukin-6 secretion and also exhibit antidepressant activity similar to amiloride. Hence, novel compounds represent an interesting starting point for the development of agents against cardiovascular diseases, thrombotic events, excessive inflammation, long-term diabetic complications and glaucoma.