gebhart/patrepeval huggingface dataset:
Adhesion-Peptide Conjugates of Thermo-Responsive Polymers Co-Electrospun into Fibrous Scaffolds Enable Growth and Enzyme-Free Recovery of Quiescent Human Corneal Stromal Cells (hCSCs) (2019)

Here we report the development of a PLA/thermo-responsive (PDEGMA) blend 3D electrospun fibre-based scaffold to create an enzymatic-free 3D cell culture platform for the expansion of mammalian cells with the desired phenotype for clinical use. Human corneal stromal cells (hCSCs) were used as an exemplar as they have been observed to de-differentiate to an undesirable myo-fibroblastic phenotype when cultured by conventional 2D cell culture methods. Scaffolds were functionalised with a cell adherence peptide sequence GGG-YIGSR by thiol-ene chemistry to improve cell adherence and phenotype support. This was obtained by functionalising the thermo-responsive polymer with a thiol (PDEGMA/PDEGSH) by co-polymerisation. These incorporated thiols react with the norbornene acid functionalised peptide (GGG-YIGSR) under UV exposure. Presence of the thiol in the scaffold and subsequent peptide attachment on the scaffolds were confirmed by fluorescence labelling, ToF-SIMS and XPS analysis. The biocompatibility of the peptide containing scaffolds was assessed by the adhesion, proliferation and immuno-staining of hCSCs. Significant increase in hCSCs adherence and proliferation was observed on the peptide containing scaffolds. Immuno-staining showed maintained expression of the desired phenotypic markers ALDH, CD34 and CD105, while showing no or low expression of the undesired phenotype marker α-SMA. This desired expression was observed to be maintained after thermo-responsive passaging and observed higher when cells were cultured on PLA scaffolds with 10 wt% PDEGMA/4 mole% PDEGS-Nor-GGG-YIGSR. This paper describes the fabrication and application of a first generation, biocompatible thermo-responsive peptide conjugates fibrous scaffolds. The ease of fabrication, successful adherence and expansion of a therapeutically relevant cell type makes these scaffolds a promising new class of materials for the application of cell culture expansion platforms in the biomaterials and tissue engineering field.
Enhancing acronym/abbreviation knowledge bases with semantic information. (2007)

Utilizing ADAM, an existing collection of (SF,LF) pairs extracted from MEDLINE, our system achieved an f-measure of 87% when assigning eight UMLS-based semantic groups to LFs. The system has been incorporated into a web interface which integrates SF knowledge from multiple SF knowledge bases. Web site: http://gauss.dbb.georgetown.edu/liblab/SFThesurus.
Estimulación de la adenilato ciclasa por las prostaglandinas E1, E2, y sus agonistas en cultivos de células de epitelio pigmentario retiniano humano (1994)

Se postula que la accion de las prostaglandinas es una de las causas del edema quistico macular en las inflamaciones intraoculares. El edema quistico macular representa un acumulo de agua en la macula, sugiriendo que existe una disminucion en la extraccion de agua a traves de barrera existente entre la retina y el epitelio pigmentario retiniano (E.P.R.). Se ha demostrado que un aumento en los niveles de AMPc inhibe el transporte de liquido a traves del E.P.R. -coroides. Despues de examinar los efectos de diferentes prostaglandinas en la adenilato ciclasa en celulas del E.P.R. De humanos, comparamos en el presente trabajo, el efecto de algunos agonistas en este sistema. Hemos examinado los agonistas de las PGs que mas estimulacion produjeron en la adenilato ciclasa (PGE1 y PGE2). Se utilizaron celulas del E.P.R. En el quinto pase para el ensayo. Celulas del E.P.R. Humano fueron incubadas en presencia de las PGE2, PGE1, asi como los analogos 16-16 dimetil PGE2 y 11 deoxi PGE1 en un rango de concentracion de 3x10-8M a 10-4 M durante 15 minutos a 370° C con l.B.M.X. 1 mM (3-isobutil-1 metil-xantina). El acumulo intracelular de AMPc fue extraido y cuantificado por radioinmunoensayo. Las prostaglandinas probablemente estimulan la adenilato ciclasa por una interaccion con los receptores E1 y E2. Nuestros resultados indican que la PGE1 y sus analogos son mas potentes que la PGE2 en la estimulacion del AMPc. Es posible que los antagonistas especificos de los receptores de PG, en combinacion con inhibidores de sus sintesis, puedan proveer un tratamiento alternativo para el edema quistico macular.
Editorial: Patient cooperative robotics in neurorehabilitation (2023)

EDITORIAL article Front. Neurorobot., 17 May 2023 Volume 17 - 2023 | https://doi.org/10.3389/fnbot.2023.1211287
578-P: Effect of Two Timings for Postprandial Exercise Onset on Hypoglycemic Risk in Adults Living with Type 1 Diabetes (2023)

Introduction: To limit hypoglycemic risk of during postprandial aerobic exercise the importance of reducing prandial insulin dose have been established with exercise starting 90-min after the meal. People with type 1 diabetes also exercise closer or further away of their mealtime and hypoglycemic risk associated with those timings may be different. Objective: We aimed to evaluate the effect of two different timings for exercise onset (60-min vs. 120-min post-meal) during moderate intensity exercise. Methods: 37 participants (25 M/ 12 F; HbA1c: 7.4 ± 0.9%) received an ultra-rapid insulin dose reduced by 50% and performed 1 hour of continuous moderate intensity exercise (at 60% of VO2peak) started either 60-min (EX60min) or 120-min (EX120min) after breakfast. Venous blood glucose was measured every 10-min during exercise. Results: Decrease in blood glucose between exercise onset and nadir (lowest point during exercise) was more important with EX120min (-68.5 ± 43.2 mg/dL, EX60min vs. -75.7 ± 39.6 mg/dL, EX120min, p=0.015). The number of hypoglycemic events during exercise and during recovery (90-min post-exercise) were similar between EX60min and EX120min (3 vs. 4 and 3 vs. 0, respectively). Postprandial glucose excursion before exercise onset was reduced with Ex60min compared to Ex120min. Conclusion: For postprandial aerobic exercise, with a reduced insulin meal bolus, hypoglycemic risk is comparable if exercise is started at 60 or 120min after the meal. Guidelines established with exercise starting 90min after the meal can probably be used for earlier or later timing. Disclosure J.Molveau: None. É.Myette-côté: None. S.Tagougui: None. N.Taleb: Consultant; Viatris Inc. E.Heyman: None. C.Suppere: None. R.Rabasa-lhoret: Consultant; Dexcom, Inc., Abbott, Janssen Pharmaceuticals, Inc., Novo Nordisk Canada Inc., Sanofi, Lilly, Tandem Diabetes Care, Inc., Insulet Corporation.
Anti-agglomeration in Cyclopentane Hydrates from Bio- and Co-surfactants (2010)

Hydrate formation in subsea pipelines is a serious problem in gas and oil production for offshore fields. Current methods are mainly based on thermodynamic inhibitors to change bulk phase properties. Thermodynamic inhibitors, such as methanol, are very effective, but large quantities, sometimes as high as a 1:1 volume of alcohol/water, are required. Kinetic inhibitors generally in a 0.005−0.02 volume ratio of surfactant/water can either inhibit hydrate formation or reduce the rate of growth. In the sea bed, the subcooling for hydrates is around 20−25 °C because of the sea bed temperature of about 4 °C. The kinetic inhibitors are not effective at such a high subcooling. An effective method is the use of anti-agglomerants, which allow for hydrate formation in the form of small particles and prevent agglomeration of such particles. Rhamnolipid biosurfactant and methanol are used recently to demonstrate anti-agglomeration in tetrahydrofuran (THF) hydrates. In this work, we present data for cyclopentane hydrates to demonstrate that a mixture of rhamnolipid and methanol is the ideal combination for effective anti-agglomeration. The formation of cyclopentane hydrates is believed to be closely analogous to methane hydrate formation because of the low solubility of cyclopentanes in water and various aspects of crytallization.
Preliminary results of ENCORE 601, a phase 1b/2, open-label study of entinostat (ENT) in combination with pembrolizumab (PEMBRO) in patients with non-small cell lung cancer (NSCLC). (2016)

e20659 Background: Treatment with single agent PD-1 blockade improves survival in patients with chemotherapy-refractory NSCLC, yet only a minority respond. Rational combination approaches are needed to improve frequency, depth, and durability of response. ENT is an oral, class I selective histone deacetylase (HDAC) inhibitor. In animal models, ENT selectively reduces immunosuppressive myeloid derived suppressor cells (MDSCs) and enhances response to immune checkpoint blockade. ENCORE 601 is a Ph1b/2 study designed to evaluate ENT in combination with PEMBRO in patients with advanced NSCLC or melanoma. Methods: Patients with Stage III/IV NSCLC previously treated with platinum-based chemotherapy were enrolled in the 3+3 dose escalation phase. ENT 3mg qW and 5mg qW PO + PEMBRO 200mg q3W IV in 21-day cycles were explored to determine the safety and MTD or RP2D. Planned correlates included tumor PD-L1 expression and change in MDSCs and regulatory T cells in peripheral blood. Results: To date, 9 patients have been enrolled (6 @ 3mg qW and 3 @ 5mg qW). No DLTs have been observed in 8 of 9 patients. One patient, treated at ENT 3mg, developed grade 3 elevated alkaline phosphatase and bilirubin during cycle 2, which were considered manifestations of immune-mediated hepatitis; this was successfully and rapidly managed by holding study drugs and administering systemic corticosteroids. Stable disease has been observed in 3 of 6 patients thus far evaluated. The longest ongoing patient is in cycle 8. In 2 of 3 patients with paired peripheral blood samples, decreases in MDSCs from baseline were observed. Nine (9) additional patients are being enrolled in the dose confirmation phase of 1b; updated safety, efficacy, and correlative data will be reported. Conclusions: ENT combined with PEMBRO appears to be well tolerated and has preliminary immunomodulatory activity as hypothesized. Clinical trial information: NCT02437136.
Association Between Antihypertensive Medication Adherence and Visit‐to‐Visit Variability of Blood Pressure (2012)

It has been hypothesized that high visit-to-visit variability (VVV) of systolic blood pressure (SBP) may be the result of poor antihypertensive medication adherence. The authors studied this association using data from 1391 individuals taking antihypertensive medication selected from a large managed care organization. The 8-item Morisky Medication Adherence Scale, administered during 3 annual surveys, captured self-report adherence, with scores<6, 6 to <8, and 8 representing low, medium. and high adherence, respectively. The mean (standard deviation [SD]) for SD of SBP across study visits was 12.9 (4.4), 13.5 (4.8), and 14.1 (4.5) mm Hg in participants with high, medium, and low self-reported adherence, respectively. After multivariable adjustment and compared with those with high self-report adherence, SD of SBP was 0.60 (95% confidence interval, 0.13-1.07) and 1.08 (95% confidence interval, 0.29-1.87) mm Hg higher among participants with medium and low self-report adherence, respectively. Results were consistent when pharmacy fill was used to define adherence. These data suggest that low antihypertensive medication adherence explains only a small proportion of VVV of SBP.
Integrated cost-optimal residential envelope retrofit decision-making and power systems optimisation using Ensemble models (2020)

The dynamic integration of building energy models and power system models is essential to analyse the potential supply-side benefits of adopting Energy Conservation Measures (ECM) at the national, regional scale. The integration of these models requires the development of linear building energy models which are numerically compatible with linear power systems models. Ensemble Calibration is an automated model calibration methodology which identifies a cluster of lumped parameter building energy models (denoted Ensemble models) using an archetype building energy model. Each lumped parameter building energy model represents an ECM configuration (i.e., a combination of ECMs). The current paper introduces a novel mechanism by which Ensemble models are integrated with power systems models in a manner such that cost-optimal retrofit decision-making problems and power systems optimisation problems can be simultaneously solved. To achieve this objective, Ensemble models are reformulated as bi-linear models, which are then co-optimised with power systems models using a multi-stage optimisation algorithm. The methodology is tested using two building energy archetypes: a detached house archetype and a mid-floor apartment archetype. The archetypes are representative of the Irish residential stock built prior to 1970. The results show that the proposed multi-stage optimisation algorithm provides computational advantages to the solution of the equivalent problem using a brute force approach (i.e., solving building-to-grid models for each ECM configuration). The proposed method is 4.73 times faster than the brute force approach when the archetypes are decoupled and 73 times faster when the models are deemed to be coupled via a power systems model.
XXI.—Nitroarylsulphuric acids and their reduction products (1929)

G. N. Burkhardt and H. Wood, J. Chem. Soc., 1929, 141 DOI: 10.1039/JR9290000141
Influence of Shock Structure on Stabilization of Hydrogen Jet Flames (2021)

Non-premixed hydrogen jet flames spouted from a nozzle with a divergent channel were investigated experimentally to clarify the effect of shock structure created in the vicinity of a nozzle exit on flame stability. The experimental results show that the flame accompanied with ideal-expanded jet was the most difficult to stabilize, compared to both conditions of under- and over-expanded jet. To better understand how the shock structures affect to flame stabilization, a concept of characteristic length Lv based on the Damköhler number in turbulent flow was proposed, and CFD including LES turbulent model was performed under the conditions that either flame can stabilize or not. Consequently, Lv in blow-out condition was longer than that in stable condition. As Lv may indicate the quantity of delay of chemical characteristic time, the effect of shock structures can be discussed in various nozzles.
RF-based connectivity management of aerial sensor networks for 3D coverage optimization (2010)

For efficient sensor coverage of large industrial and incident areas, fast and flexible strategies for collecting optical sensor data through an autonomous, wirelessly connected swarm of Micro Unmanned Aerial Vehicles (MUAV) is still an emerging challenge. Of particular interest are strategies for spatial coverage optimization of mobile networks and the acquisition of high quality image material targeting a photogrammetric 3D reconstruction of the area of interest. In MUAV based swarms continuous and excellent communication links are a key factor for the success of the overall achievement of objectives. However, disregarding communication aspects in mission strategies is a common simplification. In this paper we examine an agent-based approach that targets (a) high spatial sensor coverage and (b) high quality communication links. For these key figures, the performance of the suggested algorithm is evaluated. We particularly focus on channel aware mobility and on self organizing mesh topologies of MUAV based sensor swarms.
Detection of cabinet in equipment floor based on AlexNet and SSD model (2019)

With the rapid development of technologies such as computer technology and sensors technology, intelligent inspection robots gradually replace manual inspections in industrial inspection positions. In order to improve the accuracy and stability of the cabinet detection of inspection robot, this study proposes a new model which combines the adjusted AlexNet model and adjusted single shot multi‐box detector (SSD) model to detect cabinet and its effective information at railway station equipment floor. The first is to determine whether there is a cabinet in view based on the AlexNet. If a cabinet exists, then locate the effective information position of the objects with the SSD. The experimental results reveal that the new model can detect the cabinet, two digital metres and indicator lights more efficiently.
An Energy-Efficient Message Passing Approach in MAC Design for Wireless Sensor Networks (2008)

As wireless sensor networks are used more widely, the design of medium access control protocol will be largely various. The paper reviews Sensor MAC (S-MAC), which is the basic MAC protocol for wireless sensor networks, and points its advantages and disadvantages. Several improving S-MAC protocols that focus on different problems in S-MAC are introduced. The Fragment Indication Message Passing (FIMP), a new energy-efficient message passing approach, is proposed to solve the turnaround consumption problem in S-MAC. It exploits a set of special binary codes to indicate each fragment. Thus, the receiver can easily check the failed fragments. Moreover two ACK packets are used to reduce the possible of retransmission.
The universal planar manipulator (robotics) (2000)

This dissertation is about a novel technology for planar part manipulation. A device has been developed, called the Universal Planar Manipulator (UPM), based on a single actuator: a rigid, horizontal plate which vibrates in its own plane (3 degrees of freedom). Generic parts (bottles, tools, etc.) placed on the UPM's plate move as a result of friction. Our main contribution has been to develop control algorithms for the UPM which allow it to manipulate several parts in parallel. The UPM's actuation simplicity combined with its open workspace (no grippers) renders it appealing to existing industrial applications and novel interactive devices such as toys and active desks.
Undersized Mitral Annuloplasty Alters Left Ventricular Shape During Acute Ischemic Mitral Regurgitation (2004)

Acute proximal circumflex occlusion caused IMR and increased end-systolic LV radii of curvature in this experimental preparation. Annular reduction sufficient to abolish IMR also decreased end-systolic anterior and posterior LV ROC, which would be expected to reduce LV wall stress and oxygen consumption in these regions, both potentially beneficial effects. The long-term effects of undersized annuloplasty on LV remodeling and function, however, will require further study in chronic animal preparations or patients with chronic IMR.
Angle Diversity Trasmitter For High Speed Data Center Uplink Communications (2021)

This paper proposes an uplink optical wireless communication (OWC) link design that can be used by data centers to support communication in spine and leaf architectures between the top of rack leaf switches and large spine switches whose access points are mounted in the ceiling. The use of optical wireless links reduces cabling and allows easy reconfigurability for example when data centres expand. We consider three racks in a data center where each rack contains an Angle Diversity Transmitter (ADT) positioned on the top of the rack to realize the uplink function of a “top-of-the-rack (ToR)” or a “leaf” switch. Four receivers are considered to be installed on the ceiling where each is connected to a spine switch. Two types of optical receivers are studied which are a Wide Field-of- View Receiver (WFOVR) and an Angle Diversity Receiver (ADR). The performance of the proposed system is evaluated when the links run at data rates higher than 19 Gbps. The results indicate that the proposed approach achieves excellent performance using simple On-Off Keying (OOK) modulation.
Endoluminal Methods for Gastrotomy Closure in Natural Orifice TransEnteric Surgery (NOTES) (2006)

Natural orifice transenteric surgery (NOTES) is a new and rapidly evolving concept for intra-abdominal operations that offers the potential for a revolutionary advance in patient care. Conceptually, operations that currently require an open or laparoscopic approach could be performed without incisions in the abdomen, with their concomitant pain and scarring. A recent consensus statement by a joint group of gastrointestinal surgeons and gastroenterologists has identified several technical and technologic hurdles that would need to be overcome before NOTES becomes a clinical reality. One of the most significant requirements identified is the need for a very secure closure of the gastrotomy site that is required for scope passage and specimen removal. Although a rapidly expanding variety of transgastric procedures has been reported, only a few reports address the basic problem of gastrotomy closure. Availability of a safe and simple gastrotomy closure device, however, will be essential for the widespread adoption of the new field of NOTES. Unless new safe and simple devices for endoscopic gastrotomy closure are available and have proven efficacy, NOTES will remain in the hands of a few specialists at centers of excellence because the risk of complications due to insufficient gastrotomy closure will not be acceptable for the surgeon and gastroenterologist in general practice. In this article, we describe three new devices in development or newly on the market that are targeted to advance the safe endoscopic closure of gastrotomy from NOTES.
The Role of DNA Methylation in Mammalian Epigenetics (2001)

Genes constitute only a small proportion of the total mammalian genome, and the precise control of their expression in the presence of an overwhelming background of noncoding DNA presents a substantial problem for their regulation. Noncoding DNA, containing introns, repetitive elements, and potentially active transposable elements, requires effective mechanisms for its long-term silencing. Mammals appear to have taken advantage of the possibilities afforded by cytosine methylation to provide a heritable mechanism for altering DNA-protein interactions to assist in such silencing. Genes can be transcribed from methylation-free promoters even though adjacent transcribed and nontranscribed regions are extensively methylated. Gene promoters can be used and regulated while keeping noncoding DNA, including transposable elements, suppressed. Methylation is also used for long-term epigenetic silencing of X-linked and imprinted genes and can either increase or decrease the level of transcription, depending on whether the methylation inactivates a positive or negative regulatory element.
Compressed parametric difference frequency sound with chirp signal (2013)

The directivity of parametric difference frequency sound is narrower than that of linear sound with same frequency radiated from a sound source with same aperture size. In addition, the parametric difference frequency sound can propagate a long distance in a dissipative medium, because sound absorption at low frequency is less than those at usual ultrasound frequency for measurements and medical imaging. However, for applications of parametric difference frequency sound on measurements and imaging, that has the disadvantage of low spatial resolution because. In this study, we proposed the application of pulse compression technique with chirp signal to parametric difference frequency sound for the improvement of spatial resolution. Nonlinear propagation of ultrasound in water was numerically simulated to confirm the realization of compressed parametric difference frequency sound. A sound source at center frequency of 1 MHz was driven by up and down linear chirp signals to generate chirp difference frequency with band width of 100 to 400 kHz, and the autocorrelation function of generated difference frequency sound was calculate to archive pulse compression. The results indicated the realization of pulse compressed parametric difference frequency sound with desired pulse width which is inversely proportional to the band width.