gebhart/patrepeval huggingface dataset:
Kaiso Contributes to DNA Methylation-Dependent Silencing of Tumor Suppressor Genes in Colon Cancer Cell Lines (2008)

Abstract Aberrant CpG methylation of tumor suppressor gene regulatory elements is associated with transcriptional silencing and contributes to malignant transformation of different tissues. It is presumed that methylated DNA sequences recruit repressor machinery to actively shutdown gene expression. The Kaiso protein is a transcriptional repressor expressed in human and murine colorectal tumors that can bind to methylated clusters of CpG dinucleotides. We show here that Kaiso represses methylated tumor suppressor genes and can bind in a methylation-dependent manner to the CDKN2A in human colon cancer cell lines. The contribution of Kaiso to epigenetic silencing was underlined by the fact that Kaiso depletion induced tumor suppressor gene expression without affecting DNA methylation levels. As a consequence, colon cancer cells became susceptible to cell cycle arrest and cell death mediated by chemotherapy. The data suggest that Kaiso is a methylation-dependent “opportunistic” oncogene that silences tumor suppressor genes when they become hypermethylated. Because Kaiso inactivation sensitized colon cancer cell lines to chemotherapy, it is possible that therapeutic targeting of Kaiso could improve the efficacy of current treatment regimens. [Cancer Res 2008;68(18):7258–63]
All-optical output-port contention resolution using subcarrier-multiplexing (2002)

We demonstrate an all-optical contention resolution technique that preserves the wavelength of two same-wavelength contending incoming 2.5 Gbit/s channels. This is achieved by optically subcarrier-multiplexing one channel to a higher RF frequency beyond the first baseband channel on the same input wavelength. By using narrow (/spl sim/5 GHz) fiber Fabry-Perot filters for demultiplexing we recovered each channel using a baseband receiver with <1 dB power penalty.
Reconstruction of the Proximal Aspect of the Radius After Desmoplastic Fibroma Resection (2019)

At the 2-year follow-up, radiographs showed integration of the autograft; additionally, good results were noted with the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity and Physical Function Short Form T-score and the QuickDASH (an abbreviated version of the Disabilities of the Arm, Shoulder and Hand Score [DASH]) questionnaire, along with good range of motion.
Evaluating large-scale propensity score performance through real-world and synthetic data experiments (2018)

L1-regularization incorporates all covariates simultaneously into the propensity score model and offers propensity score performance superior to the hdPS marginal screen.
Zonation of glucokinase in rat liver changes during postnatal development (1993)

In the liver many metabolic pathways are preferentially localized in different zones of the acinus. It is assumed that this zonation allows an efficient adaptation to different states of nutrition, because alternative pathways can be regulated independently. It is reported that the rate limiting enzyme for the glycolytic pathway, glucokinase (EC 2.7.1.2), is predominantly located in the pericentral zone. The gene expression of glucokinase is induced to a maximum level after a carbohydrate-rich diet. In starved or diabetic rats glucokinase gene expression is barely detectable. In postnatal development glucokinase is induced to significant levels only from day 14 onwards. The distribution of the glucokinase protein in the rat liver lobule in the first 4 weeks of postnatal life was investigated by immunohistochemistry and compared to the distribution observed in adult rats. In adult rats considerably high levels of glucokinase are measureable as shown by immunoblotting utilizing a monospecific antibody and a photometric assay of glucokinase enzyme activity, respectively. Immunohistochemically the hepatic glucokinase protein is detected in the perivenous area. During postnatal development, the quantities of hepatic glucokinase protein and glucokinase enzyme activity start to increase significantly from day 15 onwards. Subsequently, glucokinase levels rise further until day 29. In contrast to the results obtained by immunoblotting, glucokinase is already detectable in some liver cells in sections from 6-day-old rats by immunohistochemistry. The liver lobule structure at this age is not completely developed, therefore it is not possible to definitely assign these cells to periportal or pericentral areas. At day 10 post partum the number of glucokinase expressing cells, which appear to be localized preferentially in the periportal zone, increases. In agreement with the immunoblotting, an immense increase in glucokinase activity was observed at day 14. The periportal zonation, clearly detectable at this time, remains stable until day 24. In sections from 29-day-old rats the periportal zonation begins to change into a more homogeneous pattern with a slight preference for periportal areas. The observed appearance of the periportal zonation of glucokinase during neonatal development is obviously in contrast to the perivenous expression of glucokinase in adult rats.
Supplemental Methods from Zfx Facilitates Tumorigenesis Caused by Activation of the Hedgehog Pathway (2023)

&lt;p&gt;Supplemental Materials and Methods&lt;/p&gt;
The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development (2020)

Preventing factor VIII (FVIII) inhibitors following replacement therapies with FVIII products in patients with hemophilia A remains an unmet medical need. Better understanding of the early events of evolving FVIII inhibitors is essential for risk identification and the design of novel strategies to prevent inhibitor development. The Hemophilia Inhibitor Previously Untreated Patients (PUPs) Study (HIPS; www.clinicaltrials.gov #NCT01652027) is the first prospective cohort study to evaluate comprehensive changes in the immune system during the first 50 exposure days (EDs) to FVIII in patients with severe hemophilia A. HIPS participants were enrolled prior to their first exposure to FVIII or blood products ("true PUPs") and were evaluated for different immunological and clinical parameters at specified time points during their first 50 EDs to a single source of recombinant FVIII. Longitudinal antibody data resulting from this study indicate that there are 4 subgroups of patients expressing distinct signatures of FVIII-binding antibodies. Subgroup 1 did not develop any detectable FVIII-binding immunoglobulin G (IgG) antibodies. Subgroup 2 developed nonneutralizing, FVIII-binding IgG1 antibodies, but other FVIII-binding IgG subclasses were not observed. Subgroup 3 developed transient FVIII inhibitors associated with FVIII-binding IgG1 antibodies, similar to subgroup 2. Subgroup 4 developed persistent FVIII inhibitors associated with an initial development of high-affinity, FVIII-binding IgG1 antibodies, followed by IgG3 and IgG4 antibodies. Appearance of FVIII-binding IgG3 was always associated with persistent FVIII inhibitors and the subsequent development of FVIII-binding IgG4. Some of the antibody signatures identified in HIPS could serve as candidates for early biomarkers of FVIII inhibitor development.
Magnetic properties of the Co–C60 and Fe–C60 nanocrystalline magnetic thin films (2005)

The basic magnetic properties of Co–C60 and Fe–C60 nanocrystalline magnetic thin films and the temperature effects on these properties have been investigated. Experimental results show that the Co–C60 films possess an in-plane magnetic anisotropy, but such an anisotropy is not found in the Fe–C60 films. At room temperature, the magnetic coercivity decreases with increasing C60 concentration in the Co–C60 films while it increases with increasing C60 concentration in the Fe–C60 film. Strong temperature-dependent remanence and saturation magnetization are found in both the Co–C60 and Fe–C60 films with high C60 concentration due to the nanosize grain effects. The effects of temperature on the coercivity of the Co–C60 and Fe–C60 films are different and determined by the intrinsic magnetocrystalline anisotropy energy of Co and Fe, respectively.
Preparation of High Temperature Resistant High Strength Supramolecular Gels Based on Hydrophobic Association and Hydrogen Bonding and its Application in Formation Pluggingg (2023)

Abstract The traditional chemical cross-linking method is based on the formation of covalent bonds between molecules to connect three-dimensional networks to enhance the strength of hydrogels. Although this method can significantly improve the mechanical properties, it also has many problems, such as irreversibility and fatigue. Therefore, the design and preparation of supramolecular hydrogels with high mechanical properties and good temperature resistance have very important research significance and practical value. This paper prepared a supramolecular gel with both temperature resistance and mechanical properties through hydrophobic association and hydrogen bonding, and evaluated its thermal stability, rheology, temperature resistance and pressure plugging ability. The results showed that the supramolecular gel had excellent thermal stability, and there was strong physical entanglement between its three-dimensional network structures, which made it difficult to be destroyed by increasing temperature. The excellent rheological properties of supramolecular gels enable them to maintain good viscoelastic changes in the linear viscoelastic region within the strain range of 0.1-30%. When the strain was greater than 30%, the supramolecular gel began to undergo different degrees of sol-gel phase transition, which showed that the energy storage modulus of supramolecular gel decreased. In addition, the energy storage modulus of supramolecular gel was always greater than the loss modulus in the whole frequency scanning range, and there was no intersection between the two gel and the gel always showed high elasticity. Meanwhile, the supramolecular gel still had good structure and strength after high temperature aging. Its tensile and compressive properties did not change significantly, but the color of the gel surface changed slightly, which could maintain good structural stability under high temperature environment. Supramolecular gel particles could be used as plugging materials for drilling fluid, and had excellent plugging ability of formation fractures and pores. The plugging ability of 1mm aperture plate model was up to 6.3MPa, and the plugging ability of 1mm seam width was up to 4.9MPa. Therefore, the development and application of supramolecular gel plays an important supporting role in drilling fluid plugging.
HPV Prevalence in cytomorphologically normal cervical scrapes of pregnant women as determined by PCR: The age‐related pattern (1995)

Diverging data exist on human papillomavirus (HPV) prevalence in cytomorphologically normal scrapes during pregnancy. The prevalence of HPV was therefore investigated by polymerase chain reaction method (PCR) in cytomorphologically normal scrapes of 709 pregnant women and 3,948 non-pregnant women visiting the same hospital during the same time period. The prevalence of all types of HPV among pregnant women was 9.6% (68/709) and the high risk HPV types of 16 and 18 were found in 3.1% (22/709). In the non-pregnant women the prevalence of all types of HPV was 10.9% (432/3,948) with 2.9% (116/3,948) HPV types 16 and 18. The highest prevalence of HPV was present in women at younger ages in both groups. With increasing age the prevalence declines from about 19% (15-25 yrs) to 5% (40-49 yrs). The age-adjusted odds ratio of prevalence of all types of HPV in pregnant versus non-pregnant women was 0.73 (95% CI 0.56-0.96, P = 0.025) and statistically significant. When HPV types 16 and 18 were considered, significant differences were not found. HPV of all types and types 16/18 prevalence was higher in the second half of pregnancy than in the first part but did not reach statistical significance. High HPV copy numbers in the scrapes were found during the first half of the pregnancy and not during the second half using a semi-quantitative HPV 16/18 PCR detection method. Since the difference in HPV prevalence between non-pregnant and pregnant women is very small, it is concluded that HPV prevalence in cytomorphologically normal smears is hardly influenced by pregnancy.
Reduction of outgassing rate from residual gas analyzers for extreme high vacuum measurements (1996)

One problem associated with partial pressure measurement in an extreme high vacuum region is outgassing from the residual gas analyzer (RGA) itself. In order to reduce the outgassing rate from the RGA, the temperature of the filament should be lowered, and the heat generated around the ion source of the RGA should be dissipated in the atmosphere. We modified a RGA and reduced its outgassing rate to 1.5×10−12 Pa m3/s. We also determined the partial outgassing rate from the ion source and chamber quantitatively and found that hydrogen constituted more than 99% of the outgassing from the stainless steel.
Authorʼs Reply (1992)

Psychiatry Service Department of Veterans Affairs Medical Center, Department of Psychiatry, Georgetown University School of Medicine, Washington, D.C.
Improved parameter estimation of Time Dependent Kernel Density by using Artificial Neural Networks (2018)

Time Dependent Kernel Density Estimation (TDKDE) used in modelling time-varying phenomenon requires two input parameters known as bandwidth and discount to perform. A Maximum Likelihood Estimation (MLE) procedure is commonly used to estimate these parameters in a set of data but this method has a weakness; it may not produce stable kernel estimates. In this article, a novel estimation procedure is developed using Artificial Neural Networks which eliminates this inherent issue. Moreover, evaluating the performance of the kernel estimation in terms of the uniformity of Probability Integral Transform (PIT) shows a significant improvement using the proposed method. A real-life application of TDKDE parameter estimation on NASDQ stock returns validates the flawless performance of the new technique. Keywords: Time Dependent Kernel Density Estimation, Artificial Neural Networks, Probability Integral Transform, Finance, Machine learning, 2010 MSC: 62G07, 62M45, 91G50
Tryptophan Analogues with Fixed Side‐Chain Orientation: Expanding the Scope (2020)

A generalized synthetic strategy is proposed here for the synthesis of asymmetric β-indoylated amino acids by 8-aminoquinoline (8AQ)-directed C(sp<sup>3</sup>)-H functionalization of suitably protected precursors. Peptides containing one of the four stereoisomers of (indol-3-yl)-3-phenylalanine at position 2 of the parent peptide KwFwLL-NH<sub>2</sub> (w=d-Trp) cover a wide range of activities as ghrelin receptor inverse agonists, among them the most active described until now. This application exemplarily shows how β-indoylated amino acids can be used for the systematic variation of the position of an indole group in a bioactive peptide.
Introducing WIREs Computational Statistics (2009)

This article is categorized under: Applications of Computational Statistics &gt; Organizations and Publications
Advertising a Router's Local Addresses in OSPF Traffic Engineering (TE) Extensions (2010)

OSPF Traffic Engineering (TE) extensions are used to advertise TE Link
State Advertisements (LSAs) containing information about TE-enabled
links. The only addresses belonging to a router that are advertised in
TE LSAs are the local addresses corresponding to TE-enabled links, and
the local address corresponding to the Router ID. In order to allow
other routers in a network to compute Multiprotocol Label Switching
(MPLS) Traffic Engineered Label Switched Paths (TE LSPs) to a given
router's local addresses, those addresses must also be advertised
by OSPF TE. This document describes procedures that enhance OSPF TE
to advertise a router's local addresses. [STANDARDS-TRACK]
Focused ion beam as a tool for graphene technology: Structural study of processing sequence by electron microscopy (2014)

Electron microscopy (EM) techniques are used to investigate the microstructure of ultrathin carbon layers obtained by focused ion beam induced deposition (FIBID). The investigation determines the crystalline structure, chemical bonding and elemental contents of FIBID-C materials. The effect of a thermal treatment to the ultrathin C films is analyzed. As-deposited FIBID-C is a metastable material transforming at mid-high temperatures. Evidence of its graphitization by metal catalysis is presented. Understanding of the heat transformation and crystallization is established based on the observations. Specifically, carbonization, H desorption decomposition, and graphitization, driven by high temperature metal-induced crystallization, are the identified processes. Demonstration of the graphitization of ultrathin FIBID-C enables a strategy towards graphene integrative planar technologies.
Synthesis and Physicochemical Characterization of Bis(macrocycles) Involving a Porphyrin and a meso‐Substituted Corrole – X‐ray Crystal Structure of a [(Free‐base porphyrin)–corrole]bis(pyridine)cobalt Complex (2005)

Abstract A very efficient, simple synthesis of face‐to‐face porphyrin–corrole free‐bases bearing substituents at the meso positions of the corrole ring is reported. Starting from the (porphyrin–aldehyde)zinc species 1Zn , porphyrin–corrole free‐bases ( 3M , 3C ) are obtained in two steps, in fairly good yields (40–43 %), compared to 11 steps for their corrole β‐pyrrole‐substituted counterparts. Moreover, the possibility to directly synthesize the free‐base (porphyrin–corrole)cobalt complex ( 5M or 5C ) allows for the further preparation of heterodimetallic derivatives. Crystals of the bis(pyridine) adduct of 5M have been grown; the molecular structure clearly shows that the two pyridine molecules are coordinated to the cobalt ion in endo and exo positions, leading to an open‐mouth geometry of the bis(macrocycle). The structure of 5M(py) 2 also shows intermolecular π–π interactions along the [1 0 0] direction, leading to stacking of the complexes. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Polymer‐Assisted Growth of Molybdenum Oxide Whiskers via a Sonochemical Process. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Surface Heat Treatment of Silicon Wafer Using a Xenon Arc Lamp and Its Implant Activation Applications (2015)

A surface heat-treatment method for semiconductor wafers using a xenon arc lamp is described. High absorption coefficients of silicon wafers in ultra violet (UV) region and short process time made selective surface heating possible. The surface melting of entire 150 mm diameter Si wafers was demonstrated in less than 2 s at a lamp power of 15 kW. By focusing UV light into a limited area on Si wafer surface, surface melting of a selectively exposed area was demonstrated at a much lower lamp power. The surface temperature ramp rate is estimated to be on the order of 1000°C/s. Si wafers, with various implanted species (P+, As+, B+ and BF2+) and energies (1 keV–70 keV), were annealed for implant damage recovery and electrical activation using the Xe lamp under different scanning speeds. Sheet resistance and secondary ion mass spectroscopy (SIMS) depth profiling measurement results from the scanning rapid thermal annealing (RTA) successfully demonstrated the feasibility of the technique in semiconductor RTA processing applications. Electrical activation with desired levels of dopant diffusion can be achieved by optimizing process variables such as lamp power, distance between the lamp and Si wafer, area of light exposure and scanning speed.
A fully bio-based polyimine vitrimer derived from fructose (2019)

A bio-based polyimine vitrimer containing 100% renewable carbon content has been synthesised and characterised, based on bio-based furan dialdehyde derived from fructose.
Role of MAC/RLC in achieving higher data rates and QoS in third generation (3G) UMTS system (2002)

This paper highlights the key requirements of IMT-2000. The main characteristic of the proposed 3G solution is to satisfy the IMT-2000 requirements. A layered structure based on the Open System Interconnection (OSI) model is discussed to provide multimedia services. The functions of a flexible and efficient MAC/RLC (medium access control/radio link control) sublayer are identified. The paper is concluded by presenting the proposed implementations of the MAC/RLC sublayer in the 3G UMTS system. The MAC protocol has to resolve contention between mobiles accessing the same physical resources and also has to manage the packet access procedure. Since 3G systems will offer services to mobiles having varying QoS requirements, the MAC will need to be capable of managing the access demands of different users and different service classes. This can be achieved by using reservation and priority schemes. Delay sensitive services can use a capacity reservation scheme to guarantee quality of service. Priority schemes can be used to prioritize the requests from different services.
1995 ASME Gas Turbine Award Paper: Development and Application of a Multistage Navier–Stokes Solver: Part I—Multistage Modeling Using Bodyforces and Deterministic Stresses (1998)

A multistage compressor performance analysis method based on the three-dimensional Reynolds-averaged Navier-Stokes equations is presented in this paper. This method is an average passage approach where deterministic stresses are used to ensure continuous physical properties across interface planes. The average unsteady effects due to neighboring blades and/or vanes are approximated using deterministic stresses along with the application of bodyforces. Bodyforces are used to account for the “potential” interaction between closely coupled (staged) rows. Deterministic stresses account for the “average” wake blockage and mixing effects both axially and radially. The attempt here is to implement an approximate technique for incorporating periodic unsteady flow physics that provides for a robust multistage design procedure incorporating reasonable computational efficiency. The present paper gives the theoretical development of the stress/bodyforce models incorporated in the code, and demonstrates the usefulness of these models in practical compressor applications. Compressor performance prediction capability is then established through a rigorous code/model validation effort using the power of networked workstations. The numerical results are compared with experimental data in terms of one-dimensional performance parameters such as total pressure ratio and circumferentially averaged radial profiles deemed critical to compressor design. This methodology allows the designer to design from hub to tip with a high level of confidence in the procedure.
Metrics for Evaluation and Design of Large-Displacement Linear-Motion Compliant Mechanisms (2012)

This work introduces metrics for large-displacement linear-motion compliant mechanisms (LLCMs) that evaluate the performance tradeoff between displacement and off-axis stiffness. These metrics are nondimensionalized, consisting of relevant characteristics used to describe displacement, off-axis stiffness, actuation force, and size. Displacement is normalized by the footprint of the device, transverse stiffness by a new performance characteristic called virtual axial stiffness, and torsional stiffness by the characteristic torque. These metrics account for the variation of both axial and off-axis stiffness over the range of displacement. The metrics are demonstrated for several microelectromechanical systems (MEMS) that are sensitive to size because of high cost and off-axis stiffness because of function. The use of metrics in design is demonstrated in the design of an LLCM; the resulting design shows increased values for both the travel and transverse-stiffness metrics.