gebhart/patrepeval huggingface dataset:
Supplementary Figure 1, Tables 1-4 from Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium (2023)

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Homogeneous Electrochemical Strategy for Human Telomerase Activity Assay at Single-Cell Level Based on T7 Exonuclease-Aided Target Recycling Amplification (2015)

As an important biomarker for early cancer diagnostics and a valuable therapeutic target, telomerase has attracted extensive attention concerning its detection and monitoring. Herein, a homogeneous electrochemical strategy based on T7 exonuclease-aided target recycling amplification is proposed for a simple, rapid, and highly sensitive assay of human telomerase activity from crude cancer cell extracts. In this strategy, a 5' methylene blue (MB)-labeled hairpin (HP) probe is designed, which can hybridize with the telomerase reaction products to initiate the subsequent digestion by T7 exonuclease, and a large amount of MB-labeled mononucleotides are released to result in the significantly amplified electrochemical signal. By taking advantage of the high amplification efficiency of T7-aided target recycling, the present assay enables the detection of telomerase activity at the single-cell level, which is superior or comparable to that of the reported literature. Furthermore, the assay was carried out in a homogeneous solution without complex modification or immobilization procedures, which has the merits of simplicity, rapid response, and improved recognition efficiency compared with heterogeneous biosensors. With the ability of fast detection, outstanding sensitivity, and excellent selectivity, this strategy offers a convenient and specific method for telomerase activity detection, which exhibits great potential in the practical application in telomerase-based early stage cancer diagnosis.
Electromagnetic loop vehicle detectors (1970)

Three different electromagnetic loop vehicle detector designs are described: self-tuning, bridge balance, and phase-shift. Principles of operation, design limitations, and design trade-offs for each method are presented in detail. The characteristics of the lead-in wire used are shown to be the primary limitation in loop detector performance and stability. Characteristics of commercially available wire used in present-day loop detector installations are discussed. Design equations and graphs illustrate the tradeoff considerations in the determination of optimum loop configuration and inductance.
SAXS Study of Sterically Stabilized Lipid Nanocarriers Functionalized by DNA (2012)

The structure of novel spontaneously self-assembled plasmid DNA/lipid complexes is investigated by means of small-angle X-ray scattering (SAXS) and Cryo-TEM imaging. Liquid crystalline (LC) hydrated lipid systems are prepared using the nonionic lipids monoolein and DOPE-PEG2000 and the cationic amphiphile CTAB. The employed plasmid DNA (pDNA) is encoding for the human protein brain-derived neurotrophic factor (BDNF). A coexistence of nanoparticulate objects with different LC inner organizations is established. A transition from bicontinuous membrane sponges, cubosome intermediates and unilamelar liposomes to multilamellar vesicles, functionalized by pDNA, is favoured upon binding and compaction of pBDNF onto the cationic PEGylated lipid nanocarriers. The obtained sterically stabilized nanovehicles, with confined supercoiled plasmid DNA (pBDNF), are important in the context of multicompartment lipid nanocarriers of interest for gene therapy of neurodegenerative diseases.
Total hip arthroplasty for femoral neck fractures as an urgent procedure (2016)

Background/Aim. Total hip arthroplasty (THA) is one of the most widely accepted operative methods for femoral neck fracture (FNF) in elderly. However, the data on the early THA for FNF are very limited. The aim of this study to determine if there were differences in postoperative complications and functional outcomes between an urgent and delayed THA following FNF. Methods. This prospective study included a total of 244 patients who had THA following FNF from January 2010 to January 2013. In the first group 41 FNF patients were treated with THA within less than 12 hours of admission. A total of 203 FNF patients were operated in delayed settings, of whom 162 required prolonged preoperative processing and comorbidities correction. The group II consisted of 41 FNF patients who were fit for the early surgery at admission, but the operation was delayed due to institution related reasons. Main outcome measurements included mortality, functional outcome assessement, cardiological and pulmonary complications, pressure ulcers, dislocations, infections, length of hospitalization and revisions. Results. There were no differences in terms of age, gender, type of implants, neither in mortality, nor complications. There were differences in hospital length of stay [t (51.72) = -10.25, p &lt; 0.001)]. The patients operated within less than 12 hours of admission, had significantly better scores at all three time points of functional outcome assessment: at discharge t (80) = 2.556, p &lt; 0.012; one month t (80) = 4.731, p &lt; 0.001; three months t (80) = 5.908, p &lt; 0.001. Conclusion. THA for FNF as an urgent procedure is not a widely accepted concept. Our findings indicate that the early operative treatment, does not worsen clinical outcomes, and our results give an advantage to the policy of the early THA for FNF.
Effect of standard and Aircast tennis elbow bands on integrated electromyography of forearm extensor musculature proximal to the bands (1989)

Classic tennis elbow, or lateral epicondylitis, has been described as an overuse or misuse injury resulting in a tendinitis. The extensor carpi radialis brevis (ECRB) and extensor digitorum communis (EDC) have been implicated as primary culprits in this pathology. Tennis elbow has been treated using a constrictive band placed several centimeters distal to the origin of these two muscles. Aircast (Aircast Inc., Summit, NJ) has developed a new style of band that employs an air-filled bladder as the counterpressure element. This study tested the effect of both standard and Aircast bands on EMG activity of the EDC and ECRB proximal to the band compared to control values. Ten normal subjects, ranging in age from 20 to 43 years, were tested. Right upper extremities were tested in all cases. The subjects' forearms were stabilized in the CYBEX II forearm stabilization V-pad. The ECRB and EDC were then impaled with monopolar EMG needle electrodes. The CYBEX data were recorded using the HUMAC system and the EMG data were recorded and analyzed using the Cadwell 7400. EMG data were recorded at 80% of maximum voluntary isometric contraction (MVIC) with no band, the standard band, and the Aircast band. An analysis of variance (ANOVA) with repeated measures of integrated EMG (IEMG) and Duncan's multiple comparison tests revealed that the Aircast caused a significant reduction in IEMG of the ECRB and EDC when compared with control values and the standard band. The decrease in IEMG with the standard band was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
Iterative decoding of product codes with a priori information over a Gaussian channel for still image transmission (2003)

In this paper we propose an optimized transmission system for still images. This system comprises a VQ source encoder with a compression rate of 9. The source data is encoded using a BCH product code and mapped on a 16-QAM constellation. The codebook and channel encoder have been optimized to minimize distortion in presence of transmission errors. We use a new joint source-channel turbo decoding algorithm of the product code. As compared to classical channel decoding algorithms (soft decoding), we obtain an improvement of 0.7 dB in terms of coding gain for a BER of 10/sup -5/. The PSNR of the received image exhibits an improvement of 11 dB as compared to conventional turbo decoding at low SNRs.
Patterns of early change and their relationship to outcome and early treatment termination in patients with panic disorder. (2014)

These findings suggest that early treatment changes are uniquely predictive of treatment outcome.
Wavelet estimation and multiple modeling in full wavefield inversion (2011)

Full‐wavefield inversion (FWI) is an emerging seismic technology with the potential to extract information not only from primary reflections, but also from other wave modes, such as multiples. We show that accurate modeling of multiples provides strong constraints on the amplitude, frequency spectrum and phase of the seismic wavelet. Thus the method presented here leads to a very robust estimation of the wavelet without relying upon well control. As a consequence, it is applicable to and could be particularly beneficial to the early stages of exploration.
UPTAKE AND BIOCONCENTRATION OF ATRAZINE BY SELECTED FRESHWATER ALGAE (1998)

Atrazine bioconcentration and uptake were determined for eight freshwater green algae and diatoms. Atrazine uptake was extremely rapid in all species examined, with nearly 90% of total uptake occurring within the first hour of exposure. Within each division, different species had different bioconcentration capacities, although the accumulation of atrazine was consistently higher in green algae (5.43–12.73 ng/mg) than in diatoms (0.33–1.69 ng/mg). Atrazine concentrations in the algal cells were much higher than in the medium, although the total amount of atrazine taken up by algae was small relative to the total atrazine in solution (1–3%). The ability of algal cells to accumulate atrazine was highly correlated with algal cell biovolume and surface area, and a strong relationship was observed between sensitivity to atrazine and bioconcentration, cell biovolume, and surface area. In general, higher bioconcentration factors were associated with increased atrazine sensitivity.
Formyl Peptide Receptor-Like 2 Is Expressed and Functional in Plasmacytoid Dendritic Cells, Tissue-Specific Macrophage Subpopulations, and Eosinophils (2009)

The formyl peptide receptor (FPR) is a key player in innate immunity and host defense mechanisms. In humans and other primates, a cluster of genes encodes two related receptors, FPR-like 1 and FPR-like 2 (FPRL1 and FPRL2). Despite their high sequence similarity, the three receptors respond to different sets of ligands and display a different expression pattern in leukocyte populations. Unlike FPR and FPRL1, FPRL2 is absent from neutrophils, and two endogenous peptide agonists, F2L and humanin, were recently described. In the present work, we investigated the detailed functional distribution of FPRL2 in leukocytes by quantitative PCR, flow cytometry, immunohistochemistry, and chemotaxis assays, with the aim of raising hypotheses regarding its potential functions in the human body. We describe that FPRL2 is highly expressed and functional in plasmacytoid dendritic cells and up-regulated upon their maturation. FPRL2 is also expressed in eosinophils, which are recruited but do not degranulate in response to F2L. FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions. However, in vivo, only specific subsets of macrophages express the receptor, particularly in the lung, colon, and skin, three organs chronically exposed to pathogens and exogenous aggressions. This distribution and the demonstration of the production of the F2L peptide in mice underline the potential role of FPRL2 in innate immunity and possibly in immune regulation and allergic diseases.
L'Etat et l'insécurité (2002)

info:eu-repo/semantics/published
Mixed cements for ecological concrete production and use (2004)

U radu su prikazani motivi i ciljevi pokretanja TP: Mijesani cementi za ekoloske betone. Ulaskom Hrvatske u EU, osim primjene niza normi iz podrucja metodologije ispitivanja i certifikacije cementa, pruža se i mogucnost napretka u razvoju i primjeni vise vrsta cementa. Istovremeno se radi na prilagođavanju propisa i normi iz podrucja zastite okolisa. Proizvodnjom mijesanih cemenata u tvornicama cementa, ostvaruju se ustede u potrosnji prirodnih resursa, zbrinjavaju sekundarne sirovine i smanjuje oneciscenje atmosfere. Primjenom mijesanih cemenata u proizvodnji betona, mogu se postici i određena poboljsanja trajnosnih svojstava betona, kojima se povecavaju doprinosi u održivom razvoju.
STRUCTURE OF THE EXTRACELLULAR POLYSACCHARIDE PRODUCED BY XANTHOMONAS ORYZAE (1962)

The extracellular polysaccharide isolated from cultures of Xanthomonas oryzae is composed of D-glucose (5 molecular proportions), D-glucuronic acid (2 molecular proportions), and D-mannose (5 molecular proportions). Acid hydrolysis of this polysaccharide, which contains 0.3% combined pyruvic acid, yields 2-O-β-D-glucopyranosyluronic acid D-mannose, which has been characterized as its crystalline fully methylated β-glycoside. Hydrolysis of the methylated polysaccharide gives 2,3,4,6-tetra-O-methyl-D-mannose (3 molecular proportions), 2,3,4-tri-O-methyl-D-glucuronic acid (1 molecular proportion), 2,3,6-tri-O-methyl-D-glucose (4 molecular proportions), 3,4,6-tri-O-methyl-D-mannose (2 molecular proportions), 2,6-di-O-methyl-D-glucose (3 molecular proportions), 2,3-di-O-methyl-D-glucose (1 molecular proportion). The polyalcohol derived from the polysaccharide by periodate oxidation followed by sodium borohydride reduction gives upon acid hydrolysis glycerol (2 molecular proportions), erythritol (1 molecular proportion), and D-glucose (1 molecular proportion). The general structural significance of these findings is discussed.
A Novel Approach to One Health Education and Collaboration across Academic Institutions and the Public/Private Sector (2017)

Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance global health, promote research, and foster the prevention and treatment of disease worldwide. Its goals are to improve the health and well-being of all people, advance health equity, and promote wise stewardship of the earth's environment. The latest journal impact factor is 2.90. Annals of Global Health is supported by the Program for Global Public Health and the Common Good at Boston College. It was founded in 1934 by the Icahn School of Medicine at Mount Sinai as the Mount Sinai Journal of Medicine. It is a partner journal of the Consortium of Universities for Global Health. From time to time, Annals of Global Health publishes Special Collections, a series of articles organized around a common theme in global health. Recent Special Collections have included "Local evidence and strategies in addressing NCDs Non-Communicable Diseases in Tanzania", "Universal Health Coverage through Integrated Care", and "The Minderoo-Monaco Commission on Plastics and Human Health". Global health workers interested in developing a Special Collection are strongly encouraged to contact the Managing Editor in advance to discuss the project.
A single mutation (Gly316Ala) of manganese lipoxygenase augments the hydroperoxide isomerase activity. : Mechanism of biosynthesis of epoxyalcohols (2006)

Polyunsaturated fatty acids can be bioactivated by two families of dioxygenases, which either contain non-heme iron (lipoxygenases) or heme (cyclooxygenases, linoleate diol synthases and α-dioxygenases).Lipoxygenases and their products play important roles in the pathophysiology of plants and fungi. The only known lipoxygenase with catalytic manganese (Mn-lipoxygenase) is secreted by a devastating root pathogen of wheat, the Take-all fungus Gaeumannomyces graminis. Its mycelia also contains linoleate diol synthase (LDS), which can oxidize linoleic acid to sporulation hormones.Mn-lipoxygenase belongs to the lipoxygenase gene family. Recombinant Mn-lipoxygenase was successfully expressed in the yeast Pichia pastoris with an expression level of 30 mg/L in fermentor culture. The tentative metal ligands of Mn-lipoxygenase were studied by site-directed mutagenesis. The results show that four residues His-274, His-278, His-462 and the C-terminal Val-602 likely coordinate manganese, as predicted by sequence alignments with Fe lipoxygenases.Mn-lipoxygenase (~100 kDa) contains an Asp-Pro peptide bond in the N-terminal region, which appears to hydrolyze during storage and in the acidic media during Pichia expression to an active enzyme of smaller size, mini-Mn-lipoxygenase (~70 kDa). The active form of Mn-lipoxygenase can oxygenate fatty acids of variable chain length, suggesting that the fatty acids enter the catalytic site with the ω-end (“tail first”).Mn-lipoxygenase is an R-lipoxygenase with a conserved Gly316 residue known as a determinant of stereospecificity in other R/S lipoxygenases. The Gly316Ala mutant showed an increased hydroperoxide isomerase activity and transformed 18:3n-3 and 17:3n-3 to epoxyalcohols.The genome of the rice blast fungus, Magnaporthe grisea, contains putative genes of lipoxygenases and LDS. Mycelia of M. grisea were found to express LDS activity. This enzyme was cloned and sequenced and showed 65% amino acid identity with LDS from G.graminis. Take-all and the rice blast fungi represent a constant threat to staple foods worldwide. Mn-lipoxygenase and LDS might provide new means to combat these pathogens.
Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma (2012)

The presence of drug-resistant cancer cells has been associated with poor clinical outcomes. Cisplatin is one of the most effective chemotherapeutic agents commonly used for several malignancies including oral squamous cell carcinoma (OSCC). Although cisplatin resistance is a major obstacle in cancer treatment, mechanisms by which it develops are not well understood. Midkine (MK), a heparin-binding growth factor, has various cancer-related functions. In this study, we investigated whether MK is involved in cisplatin resistance in OSCC. We demonstrated that the Sa-3R cell line, which is OSCC cisplatin-resistant, exhibited lower MK expression with slow growth compared with its parent, Sa-3 cells. In Sa-3 cells, downregulation of MK expression significantly reduced cisplatin sensitivity, cell growth, and the expression of cyclin D1 and cyclin E1. MK knockdown suppressed cellular cisplatin accumulation via induction of ATP-binding cassette efflux transporters. These data suggest that MK may play important roles in cisplatin resistance in OSCC by modulating both cell growth and intracellular cisplatin accumulation.
Microwave-Assisted Amidation of Arylacetic Acids by Reaction with 2-Aryl-ethylamines (2013)

Abstract Twenty-five amides were synthesized in almost quantitative yields by microwave-assisted condensation of arylacetic acids and 2-aryl-ethylamines under solventless conditions. The N-arylethyl-arylacetylamides are intermediates of the corresponding isoquinoline derivates. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
Models of tensile behaviour of two-phase alloys from their components (1987)

The main models (mixture laws, finite element methods, self-consistent methods) proposed to describe the stress–strain curve of a two-phase material from the stress–strain curves of its components have been considered. None of these models exactly describes the behaviour of the two-phase alloys (each phase equal vol.-%) studied (Cu–Ag and Cd–Zn).MST/473
AlN/diamond heterojunction diodes (2003)

An aluminum nitride/diamond p–n heterojunction has been realized by plasma-induced molecular-beam epitaxy growth of AlN on (100) diamond. The epitaxial nature of this heterojunction has been confirmed by high-resolution x-ray diffraction. The silicon-doped AlN film (n-type) on the natural boron-doped (p-type) diamond substrate formed a heterobipolar diode with good rectifying properties and surprisingly efficient light emission in the spectral range from 2.7 to 4.8 eV under forward bias. Results concerning the structural, electrical, and optical characterization of the AlN/diamond heterojunction are reported in this letter.
Detecting Malicious Activities Using Backward Propagation of Trustworthiness over Heterogeneous Social Graph (2013)

We present an extended trust model for detecting malicious activities in online social networks. The major idea is to perform a trust propagation process over a heterogeneous social graph in which different social activities are well modeled. We develop two trustworthiness measures and evaluate their performance of detecting malicious activities using a real Twitter data set.
GALILEO - Only a Better GPS or More? Performance Analysis with the Tool NAV-SIM (2002)

Since the European Commission (EC) decided to built up an own civil global navigation satellite system called Galileo, many people are asking why the EC want to built up an additional system. They say that they can use without any costs the U.S. navigation system GPS and, therefore, there is no need for the European GALILEO for the applications. But this is not really true. For some special applications GPS is not utilisable because it is no guarantee for the availability of the system.
Computer-Aided Approach for Rapid Post-Event Visual Evaluation of a Building Façade (2018)

After a disaster strikes an urban area, damage to the façades of a building may produce dangerous falling hazards that jeopardize pedestrians and vehicles. Thus, building façades must be rapidly inspected to prevent potential loss of life and property damage. Harnessing the capacity to use new vision sensors and associated sensing platforms, such as unmanned aerial vehicles (UAVs) would expedite this process and alleviate spatial and temporal limitations typically associated with human-based inspection in high-rise buildings. In this paper, we have developed an approach to perform rapid and accurate visual inspection of building façades using images collected from UAVs. An orthophoto corresponding to any reasonably flat region on the building (e.g., a façade or building side) is automatically constructed using a structure-from-motion (SfM) technique, followed by image stitching and blending. Based on the geometric relationship between the collected images and the constructed orthophoto, high-resolution region-of-interest are automatically extracted from the collected images, enabling efficient visual inspection. We successfully demonstrate the capabilities of the technique using an abandoned building of which a façade has damaged building components (e.g., window panes or external drainage pipes).
The influence of the strength of bone on the deformation of acetabular shells (2015)

Concerns have been raised that deformation of acetabular shells may disrupt the assembly process of modular prostheses. In this study we aimed to examine the effect that the strength of bone has on the amount of deformation of the acetabular shell. The hypothesis was that stronger bone would result in greater deformation. A total of 17 acetabular shells were inserted into the acetabula of eight cadavers, and deformation was measured using an optical measuring system. Cores of bone from the femoral head were taken from each cadaver and compressed using a materials testing machine. The highest peak modulus and yield stress for each cadaver were used to represent the strength of the bone and compared with the values for the deformation and the surgeon's subjective assessment of the hardness of the bone. The mean deformation of the shell was 129 µm (3 to 340). No correlation was found between deformation and either the maximum peak modulus (r² = 0.011, t = 0.426, p = 0.676) or the yield stress (r² = 0.024, t = 0.614, p = 0.549) of the bone. Although no correlation was found between the strength of the bone and deformation, the values for the deformation observed could be sufficient to disrupt the assembly process of modular acetabular components.