gebhart/patrepeval huggingface dataset:
Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: A case report (2017)

Whether somatostatin analogs for acromegaly improve or worsen a patient's glycemic profile is controversial. A risk of hypoglycemia should be presumed, especially when patients receive insulin therapy, as the package inserts caution. However, a detailed clinical course of such a case has never been reported in research articles. An 80-year-old Japanese female diabetes patient treated with insulin therapy was diagnosed with acromegaly, and the somatostatin analog, lanreotide, was given. On day 4 of lanreotide treatment, repeated hypoglycemia as a result of exogenous insulin arose and the patient required inpatient care. After lanreotide treatment, the total daily insulin dose could be reduced, but her fasting C-peptide level decreased from 1.6 to 0.4 ng/mL, implying improved insulin resistance and impaired endogenous insulin secretion. In the present case, marked alteration surrounding lanreotide administration was observed; careful co-administration with insulin therapy is required, as the package insert cautions.
Examining the effect of task on viewing behavior in videos using saliency maps (2012)

Research has shown that when viewing still images, people will look at these images in a different manner if instructed to evaluate their quality. They will tend to focus less on the main features of the image and, instead, scan the entire image area looking for clues for its level of quality. It is questionable, however, whether this finding can be extended to videos considering their dynamic nature. One can argue that when watching a video the viewer will always focus on the dynamically changing features of the video regardless of the given task. To test whether this is true, an experiment was conducted where half of the participants viewed videos with the task of quality evaluation while the other half were simply told to watch the videos as if they were watching a movie on TV or a video downloaded from the internet. The videos contained content which was degraded with compression artifacts over a wide range of quality. An eye tracking device was used to record the viewing behavior in both conditions. By comparing the behavior during each task, it was possible to observe a systematic difference in the viewing behavior which seemed to correlate to the quality of the videos.
Accurate tuning of 90° cells in a FODO lattice (2002)

The Superconducting Super Collider was designed with a very exacting emittance budget. In order to avoid emittance dilution in the transfer of beam from the Low Energy Booster to the Medium Energy Booster, it is helpful to ensure that the transfer line connecting the two machines is tuned as designed. We discuss beam-based techniques for ensuring that the transfer line is tuned as designed, and errors associated with this procedure.
Inhibition ofStreptococcus mutanspolysaccharide synthesis by molecules targeting glycosyltransferase activity (2016)

Glycosyltransferase (Gtf) is one of the crucial virulence factors of Streptococcus mutans, a major etiological pathogen of dental caries. All the available evidence indicates that extracellular polysaccharide, particularly glucans produced by S. mutans Gtfs, contribute to the cariogenicity of dental biofilms. Therefore, inhibition of Gtf activity and the consequential polysaccharide synthesis may impair the virulence of cariogenic biofilms, which could be an alternative strategy to prevent the biofilm-related disease. Up to now, many Gtf inhibitors have been recognized in natural products, which remain the major and largely unexplored source of Gtf inhibitors. These include catechin-based polyphenols, flavonoids, proanthocyanidin oligomers, polymeric polyphenols, and some other plant-derived compounds. Metal ions, oxidizing agents, and some other synthetic compounds represent another source of Gtf inhibitors, with some novel molecules either discovered by structure-based virtual screening or synthesized based on key structures of known inhibitors as templates. Antibodies that inhibit one or more Gtfs have also been developed as topical agents. Although many agents have been shown to possess potent inhibitory activity against glucan synthesis by Gtfs, bacterial cell adherence, and caries development in animal models, much research remains to be performed to find out their mechanism of action, biological safety, cariostatic efficacies, and overall influence on the entire oral community. As a strategy to inhibit the virulence of cariogenic microbes rather than eradicate them from the microbial community, Gtf inhibition represents an approach of great potential to prevent dental caries.
Immunological Events Underlying the Induction of T Cell Non-Responsiveness (1994)

T lymphocytes recognise antigen in the form of short peptides complexed with the class I and II products of the Major Histocompatibility Complex (MHC). Cellular activation follows T cell recognition of peptide-MHC complexes at immunogenic cell surface concentrations together with the participation of the appropriate costimulatory signals. Interaction of TCRs and peptide-MHC complexes under inappropriate conditions may result in antigen-specific non-responsiveness, commonly referred to as anergy. Here we review some recent model systems which have been employed to study the phenomenon of anergy and the use of peptides to induce antigen-specific non-responsiveness both in vitro and in vivo.
On physical frame time-slot switching over DWDM (2004)

The merging trend of three separate networks, i.e. telephone, cable TV and computer networks, demands underlying communication systems to provide a mechanism to transmit and switch bit streams at very high speed, and to satisfy different users' QoS requirements. DWDM, with its transmission rate at tens of tera bits per second in a single fiber, becomes the most promising candidate for such convergence. However, switching techniques in DWDM have not yet fledged for such a merged high-speed network. We present a novel concept called the physical frame time-slot switching (PFTS). With PFTS, transmission time of a fixed-length physical frame is defined as a "time-slot", and used for multiplexing a single lambda channel and for user data switching over a DWDM platform. A maximum length of Ethernet MAC frame is exactly fitted into a PFT (physical frame time-slot), and one or more PFT(s) can be assigned to a time-critical user data stream according to required QoS parameters, such as throughput and time delay. PFT switching operates in an asynchronous mode on the basis of single PFT in a lambda; and hence eliminates the need of lambda switching and global synchronization among clocks in a network. In an "out-band signaling" network, PFTS enables user data transfer platform to be reduced to a single physical layer.
Charge-transfer excited states of ruthenium(II) complexes. II. Relation of level parameters to molecular structure (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge-transfer excited states of ruthenium(II) complexes. II. Relation of level parameters to molecular structureG. D. Hager, R. J. Watts, and G. A. CrosbyCite this: J. Am. Chem. Soc. 1975, 97, 24, 7037–7042Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ja00857a014https://doi.org/10.1021/ja00857a014research-articleACS PublicationsRequest reuse permissionsArticle Views616Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synchronization dynamics and evidence for a repertoire of network states in resting EEG (2012)

Intrinsically driven neural activity generated at rest exhibits complex spatiotemporal dynamics characterized by patterns of synchronization across distant brain regions. Mounting evidence suggests that these patterns exhibit fluctuations and nonstationarity at multiple time scales. Resting-state electroencephalographic (EEG) recordings were examined in 12 young adults for changes in synchronization patterns on a fast time scale in the range of tens to hundreds of milliseconds. Results revealed that EEG dynamics continuously underwent rapid transitions between intermittently stable states. Numerous approximate recurrences of states were observed within single recording epochs, across different epochs separated by longer times, and between participants. For broadband (4-30 Hz) data, a majority of states could be grouped into three families, suggesting the existence of a limited repertoire of core states that is continually revisited and shared across participants. Our results document the existence of fast synchronization dynamics iterating amongst a small set of core networks in the resting brain, complementing earlier findings of nonstationary dynamics in electromagnetic recordings and transient EEG microstates.
Evidence for the Involvement of Sucrose Phosphate Synthase in the Pathway of Sugar Accumulation in Sucrose-Accumulating Tomato Fruits (1992)

To better understand the mechanism of sugar unloading and sugar concentration in hexose- and sucrose-accumulating tomato fruits (Lycopersicon chmielewskii and L. esculentum, respectively) and to determine the causes of the late accumulation of sucrose present in sucrose-accumulating tomato fruits, the assimilation of [(3)H](fructosyl)-sucrose was studied. Key enzymes involved in carbohydrate metabolism were also assayed. The results demonstrated that the low level of sucrose present in young fruits accumulates directly without undergoing hydrolysis, suggesting a symplastic pathway for sucrose unloading. By contrast, the large quantity of the sucrose present in ripe sucrose-accumulating fruits originates from hydrolysis and resynthesis, suggesting an apoplastic pathway for sucrose unloading. The increase in sucrose level observed in sucrose-accumulating fruits is associated with a gradual decline in invertase activity and an increase in sucrose phosphate synthase activity. This latter enzyme seems to play a key biochemical role in the accumulation of sucrose and the establishment of a high sugar content in tomato fruits.
Draft Genome Sequence of Streptococcus sp. X13SY08, Isolated from Murray Cod ( Maccullochella peelii peelii ) (2016)

Streptococcus sp. X13SY08, isolated from freshwater Murray cod ﬁsh, likely presents a novel species of Streptococcus. Here, we present an annotated draft genome sequence of this species, which will improve our understanding of its physiology and pathogenesis.
Effect of Core-Forming Molecules on Molecular Weight Distribution and Degree of Branching in the Synthesis of Hyperbranched Polymers (1998)

The polydispersity index, the molecular weight distribution (MWD), and the degree of branching ( ) are calculated for hyperbranched polymers obtained in self-condensing vinyl polymerization of AB* monomers in the presence of a core-forming molecule (i.e. a multifunctional initiator, Bf*). Two cases are considered: (a) batch polymerization, i.e., with all components mixed together; (b) semibatch polymerization, i.e., slow addition of the monomer to the core-forming molecule. The results obtained for the latter case are also valid for polycondensation of AB2 monomers. The presence of core-forming molecules leads to a considerable narrowing of the MWD's, the polydispersity index decreasing with increasing initiator functionality, f. In the batch process, we find w/ n ≈ 1 + n/f2 and in the semibatch mode w/ n ≈ 1 + 1/f. The degree of branching obtained in semibatch mode approaches = 2/3, which is higher than for the synthesis using a batch process with or without initiator. The polymers resulting from semibatch mode are predicted to consist of highly branched cores, while the outer parts of the molecules contain the majority of the functional groups. Thus, they are closer to dendrimers than the polymers obtained in batch mode.
ChemInform Abstract: CHARGE‐SHIFT PROBES OF MEMBRANE POTENTIAL. SYNTHESIS (1984)

Abstract Die Darstellung verschiedener Aminostyryl‐pyridinium‐Verbindungen wird beschrieben.
Regulation of Riboflavin Biosynthesis in Bacillus subtilis Is Affected by the Activity of the Flavokinase/Flavin Adenine Dinucleotide Synthetase Encoded by ribC (1998)

This work shows that the ribC wild-type gene product has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism of Bacillus subtilis, as growth of a ribC deletion mutant strain was dependent on exogenous supply of FMN and the presence of a heterologous FAD-synthetase gene in its chromosome. Upon cultivation with growth-limiting amounts of FMN, this ribC deletion mutant strain overproduced riboflavin, while with elevated amounts of FMN in the culture medium, no riboflavin overproduction was observed. In a B. subtilis ribC820 mutant strain, the corresponding ribC820 gene product has reduced flavokinase/FAD-synthetase activity. In this strain, riboflavin overproduction was also repressed by exogenous FMN but not by riboflavin. Thus, flavin nucleotides, but not riboflavin, have an effector function for regulation of riboflavin biosynthesis in B. subtilis, and RibC seemingly is not directly involved in the riboflavin regulatory system. The mutation ribC820 leads to deregulation of riboflavin biosynthesis in B. subtilis, most likely by preventing the accumulation of the effector molecule FMN or FAD.
Investigation of the directional emissivity of materials using infrared thermography coupled with a periodic excitation (2016)

This article concerns the determination of the directional emissivity of materials. Several materials (conducting materials or dielectrics) are investigated and the influence of surface roughness is also considered. The experimental method used for the determination is based on the use of a periodic excitation and the recording of the surface temperature variations of the sample using infrared thermography. Several consecutive measurements are performed for emission angles varying from 0 (for the determinat ion of normal emissivity) to 85. The experimental device developed (SPIDER instrument) is simple compared to existing devices but the variation of directional emissivity is limited to the spectral bandwith of the camera used. program to acquire the temperature of the Duralumin plate and to generate the control signal of the power amplifier and the camera synchronization signal.
Hierarchically-Designed 3D Flower-Like Composite Nanostructures as an Ultrastable, Reproducible, and Sensitive SERS Substrate (2017)

Surface-enhanced Raman spectroscopy (SERS) is an attractive tool in the analytical sciences due to its high specificity and sensitivity. Because SERS-active substrates are only available as two-dimensional arrays, the fabrication of three-dimensional (3D) nanostructures allows for an increased number of hot spots in the focus volume, thus further amplifying the SERS signal. Although a great number of fabrication strategies for powerful SERS substrates exist, the generation of 3D nanostructures with high complexity and periodicity is still challenging. For this purpose, we report an easy fabrication technique for 3D nanostructures following a bottom-up preparation protocol. Enzymatically generated silver nanoparticles (EGNPs) are prepared, and the growth of hierarchically-designed 3D flower-like silica-silver composite nanostructures is induced by applying plasma-enhanced atomic layer deposition (PE-ALD) on the EGNPs. The morphology of these nanocomposites can be varied by changes in the PE-ALD cycle number, and a flower height of up to 10 μm is found. Moreover, the metallized (e.g., silver or gold) 3D nanostructures resulting from 135 PE-ALD cycles of silica creation provide highly reproducible SERS signals across the hydrophobic surface. Within this contribution, the morphological studies, optical properties, as well as the SERS response of these metallized silica-silver composite nanostructures applying vitamin B2 as a model analyte are introduced.
Inert competitive adsorption for the inhibition of oligomerization of alkenes during alcohol dehydration (2018)

Inert competitive adsorbents inhibit secondary undesired reactions.
Concept development for a minimally invasive Autonomous Underwater Vehicle (2020)

We are presenting the concept, initial developments and in-situ component tests towards an optically tethered underwater vehicle (OTV). The concept is developed to enable operations in close proximity to the ocean floor without disturbing the sea-floor interface. During a recent technology cruise in the Ligurian Sea (22. - 25. February 2020) some of the crucial sub-components, such as bottom camera, optical communication module and overall system hardware were tested successfully. Close range direct control using optical communication was tested and qualitatively evaluated through purposely disturbed suspended sediment.
Mesenchymal stem cell therapy in the treatment of hip osteoarthritis (2017)

This study was performed to investigate the safety and efficacy of the intra-articular infusion of <i>ex vivo</i> expanded autologous bone marrow-derived mesenchymal stem cells (BM-MSC) to a cohort of patients with articular cartilage defects in the hip. The above rationale is sustained by the notion that MSCs express a chondrocyte differential potential and produce extracellular matrix molecules as well as regulatory signals, that may well contribute to cure the function of the damaged hip joint. A cohort of 10 patients with functional and radiological evidences of hip osteoarthritis, either in one or both legs, was included in the study. BM-MSC (the cell product) were prepared and infused into the damaged articulation(s) of each patient (60 × 10<sup>6</sup> cells in 3 weekly/doses). Before and after completion of the cell infusion scheme, patients were evaluated (hip scores for pain, stiffness, physical function, range of motion), to assess whether the infusion of the respective cell product was beneficial. The intra-articular injection of three consecutive weekly doses of <i>ex vivo</i> expanded autologous BM-MSC to patients with articular cartilage defects in the hip and proved to be a safe and clinically effective treatment in the restoration of hip function and range of motion. In addition, the statistical significance of the above data is in line with the observation that the radiographic scores (Tönnis Classification of Osteoarthritis) of the damaged leg(s) remained without variation in 9 out of 10 patients, after the administration of the cell product.
Oil Field Chemicals Synergy Upstream Arab Heavy Crude Handling Facilities (2012)

Abstract The presentation key objective is to show how synergizing the use of corrosion inhibitor and demulsifiers has enhanced the performance and optimized the cost of Oil Field Chemical (OFC) treatment at Safaniya Onshore Arab Heavy wet crude handling facilities. The various steps involved in synergizing the use of oil field chemicals at Safaniya Onshore Arab Heavy wet crude handling facilities have also been discussed. The key performance factors used to assess the overall impact of the process including the total cost of chemical treatment, the effective mitigation of corrosion in the system, the oil in water content in the produced water system, other process parameters like emulsion and foaming tendency were addressed. Synergizing the use of OFC at Safaniya Onshore Arab Heavy wet crude handling facilities has resulted in chemical treatment cost savings of approximately $2.0 MM per year, better treatment of produced water system and improved corrosion mitigation efficiency of 99.6%.
Building Performance Simulation (2023)

Abstract Simulation is a proven technique that uses computational, mathematical, and machine learning models to represent the physical characteristics, expected or actual operation, and control strategies of a building and its energy systems. Simulations can be used in a number of tasks along the deep renovation life cycle, including: (a) integrating simulations with other knowledge-based systems to support decision-making, (b) using simulations to evaluate and compare design scenarios, (c) integrating simulations with real-time monitoring and diagnostic systems for building energy management and control, (d) integrating multiple simulation applications, and (e) using virtual reality (VR) to enable digital building design and operation experiences. While building performance simulation is relatively well established, there are numerous challenges to applying it across the renovation life cycle, including data integration from fragmented building systems, and modelling human-building interactions, amongst others. This chapter defines the building performance simulation domain outlining significant use cases, widely used simulation tools, and the challenges for implementation.
MSE optimal bit rate allocation in the application of JPEG2000 part 2 to meteorological data (2004)

The problem of optimal bit rate allocation for 3-D JPEG2000 compression is dicussed. In this paper we consider data where the 2-D slices are compressed using JPEG2000, and the third dimension is decorrelated using the Karhunen-Loeve Transform. Here two new methods are proposed. The first approach is called the Rate Distortion Optimal (RDO) method and is based on Post-Compression Rate-Distortion (PCRD) optimization concept. The second approach is here called the Mixed Model (MM) approach and consists of extending the traditional high-resolution model with a region that is accurate for low bit rates. The proposed bit allocation methods are tested by applying them to Meteorological (Met) data. The specific data set used was generated by the Battlescale Forecast Model (BFM). The test results shows that these approach significantly reduces the computational complexity.