gebhart/patrepeval huggingface dataset:
Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the actinomycete Streptomyces coelicolor A3(2) (1997)

The ATP-dependent phosphofructokinase (ATP-PFK) of Streptomyces coelicolor A3(2) was purified to homogeneity (1,600-fold) and characterized (110 kDa, with a single type of subunit of 40 kDa); it is allosterically inhibited by phosphoenolpyruvate. Cloning of the pfk gene of S. coelicolor A3(2) and analysis of the deduced amino acid sequence (343 amino acids; 36,667 Da) revealed high similarities to the PPi-PFK enzyme from Amycolatopsis methanolica (tetramer, nonallosteric; 70%) and to the allosteric ATP-PFK enzymes from other bacteria, e.g., Escherichia coli (tetramer; 37%) and Bacillus stearothermophilus (tetramer, 41%). Further structural and functional analysis of the two actinomycete PFK enzymes should elucidate the features of these proteins that determine substrate specificity (ATP versus PPi) and allosteric (in)sensitivity.
Frequency Ranges and Radio Licensing Regulations (2010)

Because radio frequency identification (RFID) systems generate and radiate electromagnetic waves, they are legally classified as radio systems. The function of other radio services must under no circumstances be disrupted or impaired by the operation of RFID systems. The International Telecommunication Union (ITU) is an international organization that works with technical and administrative questions regarding telecommunication. Its main tasks include standardisation, allocation and coordination of radio frequencies. It also provides extensive consulting to developing countries regarding the expansion of telecommunication services and networks. In Europe, the recommendations of the European Radiocommunications Committee (ERC) serve as the basis for national legislative and licensing regulations for radio systems. At first glance, a comparison of different licensing regulations appears to be rather difficult as different countries use different measuring units and distances. This chapter will therefore look at the conversion of different values for inductive as well as for UHF and microwave systems. Controlled Vocabulary Terms radiofrequency identification; telecommunication networks
The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration (2015)

Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.
Integrated analysis of error detection and recovery (1985)

An integrated modeling and analysis of error detection and recovery is presented. When fault latency and/or error latency exist, the system may suffer from multiple faults or error propagations which seriously deteriorate the fault-tolerant capability. Several detection models that enable analysis of the effect of detection mechanisms on the subsequent error handling operations and the overall system reliability were developed. Following detection of the faulty unit and reconfiguration of the system, the contaminated processes or tasks have to be recovered. The strategies of error recovery employed depend on the detection mechanisms and the available redundancy. Several recovery methods including the rollback recovery are considered. The recovery overhead is evaluated as an index of the capabilities of the detection and reconfiguration mechanisms.
Biológia BSc záróvizsga felkészülést elősegítő olvasóleckék (2020)

A biologia BSc zarovizsga tetelek rovid vazlatos osszefoglalasa, az osszefuggesek kiemelese az egyes temak kozt.
SEM analysis of microstructure of adhesive interface between resin cementand dentin treated with self-etching primer (2011)

The purpose of this study was to examine the microstructure of the adhesive interface between resin cement and dentin treated with a self-etching primer by SEM in order to clarify the adhesive efficiencies of four self-etch type resin cement systems, Bistite II (BII), Linkmax (LM), Panavia F2.0 (PF), and ResiCem (RC) to dentin. The fluidity and inorganic filler content of these cements were also determined to examine their influences on the adhesion. A hybrid layer with 0.5-1.5 µm thickness and many resin tags could be confirmed clearly at the interface between BII cement and dentin, but was not observed distinctly for the other resin cements. It was suggested that the hybrid layer and resin tags might contribute to the high adhesive efficiency for BII. As the fluidity of cement had been adjusted to be suitable for luting in all cements, it did not significantly influence the adhesive efficiency of cement.
Optimal Comfort Conditions in Residential Houses (2020)

The aim of this paper is to determine the optimal indoor comfort conditions for residential houses in two European countries through a thorough statistical analysis. Information from residential indoor environmental conditions, occupants' feedback and European standards are utilized. This analysis aims to understand and determine the optimal environmental conditions in indoor spaces based on occupants' satisfaction. The experimental results illustrate that the proposed analysis and its results can be the basis for the optimal indoor environmental conditions determination. A comfortable indoor environment was found to be when the indoor temperature is from 21.5 °C to 23.4 °C and humidity is from 43.5% to 46%. The visual comfort was estimated as neutral from 93 to 124 lux.
Evaluation of dengue serological tests available in Puerto Rico for identification of prior dengue infection for prevaccination screening (2019)

We assessed a dengue IgG rapid diagnostic test (RDT) and IgG enzyme-linked immunosorbent assay (ELISA) to determine their suitability for dengue prevaccination screening. Each exhibited ≥99% specificity. The RDT demonstrated no Zika cross-reactivity, while the ELISA displayed greater sensitivity. Both could safely guide vaccination in Puerto Rico pending availability of improved serotests.
Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake (2019)

Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age and body region on skin homeostasis, epidermal differentiation, and drug uptake. Fibroblasts derived from the breast skin of female 20- to 30-year-olds or 60- to 70-year-olds and fibroblasts from juvenile foreskin (<10 years old) were compared in cell monolayers and in reconstructed human skin (RHS). RHS containing aged fibroblasts differed from its juvenile and adult counterparts, especially in terms of the dermal extracellular matrix composition and interleukin-6 levels. The site from which the fibroblasts were derived appeared to alter fibroblast-keratinocyte crosstalk by affecting, among other things, the levels of granulocyte-macrophage colony-stimulating factor. Consequently, the epidermal expression of filaggrin and e-cadherin was increased in RHS containing breast skin fibroblasts, as were lipid levels in the stratum corneum. In conclusion, the region of the body from which fibroblasts are derived appears to affect the epidermal differentiation of RHS, while the age of the fibroblast donors determines the expression of proteins involved in wound healing. Emulating patient heterogeneity in preclinical studies might improve the treatment of age-related skin conditions.
A Framework for Robot Manipulation: Skill Formalism, Meta Learning and\n Adaptive Control (2018)

In this paper we introduce a novel framework for expressing and learning\nforce-sensitive robot manipulation skills. It is based on a formalism that\nextends our previous work on adaptive impedance control with meta parameter\nlearning and compatible skill specifications. This way the system is also able\nto make use of abstract expert knowledge by incorporating process descriptions\nand quality evaluation metrics. We evaluate various state-of-the-art schemes\nfor the meta parameter learning and experimentally compare selected ones. Our\nresults clearly indicate that the combination of our adaptive impedance\ncontroller with a carefully defined skill formalism significantly reduces the\ncomplexity of manipulation tasks even for learning peg-in-hole with\nsubmillimeter industrial tolerances. Overall, the considered system is able to\nlearn variations of this skill in under 20 minutes. In fact, experimentally the\nsystem was able to perform the learned tasks faster than humans, leading to the\nfirst learning-based solution of complex assembly at such real-world\nperformance.\n
Multiscale image segmentation by integrated edge and region detection (1997)

This paper is concerned with the detection of low-level structure in images. It describes an algorithm for image segmentation at multiple scales. The detected regions are homogeneous and surrounded by closed edge contours. Previous approaches to multiscale segmentation represent an image at different scales using a scale-space. However, structure is only represented implicitly in this representation, structures at coarser scales are inherently smoothed, and the problem of structure extraction is unaddressed. This paper argues that the issues of scale selection and structure detection cannot be treated separately. A new concept of scale is presented that represents image structures at different scales, and not the image itself. This scale is integrated into a nonlinear transform which makes structure explicit in the transformed domain. Structures that are stable (locally invariant) to changes in scale are identified as being perceptually relevant. The transform can be viewed as collecting spatially distributed evidence for edges and regions, and making it available at contour locations, thereby facilitating integrated detection of edges and regions without restrictive models of geometry or homogeneity. In this sense, it performs Gestalt analysis. All scale parameters of the transform are automatically determined, and the structure of any arbitrary geometry can be identified without any smoothing, even at coarse scales.
Reducing Handoff Latency for WiMAX Networks Using Mobility Patterns (2010)

In recent years, Worldwide Interoperability for Microwave Access (WiMAX) has become an important technology providing wireless connections for mobile terminals in a wireless Metropolitan Area Network (MAN), due to its large radio range. In a MAN environment, wireless clients always have high mobility; therefore, it is possible that the mobile clients will move away from the service coverage of serving base stations and change their associating base stations. The process of switching between different base stations is known as the handoff process. During the handoff process, the connection between the mobile terminal and the serving base station ceases. The quality of mobile wireless networks is significantly affected by handoff latency and packet loss ratio. In this paper, we propose a fast handoff scheme using mobility patterns for WiMAX networks. Mobility patterns are adopted to predict the next base station and therefore waive unnecessary scans, and the serving base station forwards the data packets received during the handoff process to the target base station for the minimizing of the packet loss ratio. Extensive simulation experiments are conducted to evaluate the performance of the proposed scheme. The results demonstrate that our scheme can shorten the handoff latency.
A pilot randomized trial to evaluate the efficacy of oral and nasal povidone iodine in reducing the burden of severe acute respiratory syndrome coronavirus 2 RNA in patients with coronavirus disease 2019 (2022)

A pilot randomized trial to evaluate the efficacy of oral and nasal povidone iodine in reducing the burden of severe acute respiratory syndrome coronavirus 2 RNA in patients with coronavirus disease 2019
CD46 Represents a Target for Adenoviral Gene Therapy of Malignant Glioma (2006)

Malignant gliomas remain refractory to adenovirus serotype 5 (Ad5) gene therapy because of the lack of the primary adenoviral receptor, the coxsackie-adenovirus receptor (CAR), on tumor cells. To bypass the dependence on CAR, we investigated the expression of adenovirus serotype 3 (Ad3) receptor, or CD46, on glioma cells. First, we analyzed the expression of CD46 by RT-PCR on primary and passaged glioma cells. We then performed immunofluorescence studies to examine protein expression of CAR and CD46 on the same tumor lines. Finally, we constructed a replication-defective Ad vector that binds to CD46 and contains a luciferase transgenic cassette in place of the deleted E1 region: Ad5/3 (containing tail/shaft domain of Ad5 and knob domain of Ad3). These vectors were analyzed in vitro and in vivo against malignant glioma and compared with wild-type Ad5 or control vector Ad3/5 (containing tail of Ad5, shaft of Ad3, and knob of Ad5). The chimeric vector Ad5/3 showed a significant increase in the transduction efficiency of glioma tumor cells. At the same time, blocking the CD46 receptor caused a 65% inhibition of adenoviral infection when using Ad5/3. Taken together, these results indicate that CD46 is overexpressed by malignant glioma. Retargeting to the Ad3 receptor enhances gene transfer and offers a novel target for gene therapy of malignant brain tumors.
Measurement of two-dimensional magnetostriction of a non-oriented electrical steel sheet under shear stress (2015)

The magnetic properties of electrical steel sheet used in motor cores are influenced by mechanical stress due to the inverse effect of the magnetostriction. Therefore, it is necessary to measure the magnetostriction of the electrical steel sheet in order to clarify the relationships between the str ess and magnetic properties. The present paper investigates the influence of shear stress on the two-dimensional magnetostriction of a non-oriented electrical steel sheet. The principal magnetostriction in the two-dimensional magnetostriction of a non-oriented electrical steel sheet is measured while varying the shear stress. The obtained results revealed that the amplitude of the principal magnetostriction along the 45° and 135° directions varied significantly when the shear stress was applied.
Convergence of Asynchronous Optimization Flow Control (2000)

We proposed earlier an optimization approach to reactive flow control where the objective of the control is to maximize the total source utility over their transmission rates. The source utility functions model their valuation of bandwidth and can be different for different sources. The control mechanism is derived as a gradient projection algorithm to solve the dual problem. In this paper we generalize the algorithm and the convergence result to an asynchronous setting where the computations at and the communications among the links and sources are uncoordinated and based on possibly outdated information.
Macromol. Biosci. 2/2017 (2017)

Back Cover: Aggregation-prone antibody single-chain variable fragments (scFv) are refolded from urea solutions in the presence of amphiphilic derivatives of poly(sodium acrylate) playing the role of artificial chaperons. Weak noncovalent interactions with the polymers impart solubility to partly-folded scFv intermediates, resulting in recovery of the native-like structure. This is reported by Nicolas Martin, Narciso Costa, Frank Wien, Françoise M. Winnik, Céline Ortega, Amaury Herbet, Didier Boquet, and Christophe Tribet, article number 1600213.
The nucleotide sequence and gene organization of red clover necrotic mosaic virus RNA-2 (1988)

Red clover necrotic mosaic virus, a member of the dianthovirus group, is characterized by a genome composed of two nonhomologous single-stranded RNAs of approximately 4.0 (RNA-1) and 1.4 kb (RNA-2). The complete nucleotide sequence of the RNA-2 has been determined. RNA-2 is 1448 nucleotides in length with a 5' terminal m7G cap and no 3' terminal poly-A tail or 5' terminal VPg. An open reading frame beginning at the first initiation codon at nucleotide 80 and ending at nucleotide 1030 has been identified which can encode a polypeptide of 35 kDa. RNA-2 directs the synthesis of a 35 kDa polypeptide in vitro. SP6 and T7 transcripts from full length RNA-2 cDNA clones directed the synthesis of a polypeptide with the same electrophoretic mobility as the polypeptide directed from authentic RNA-2. Clones with various 3' terminal deletions both outside and within the 35 kDa open reading frame were transcribed and translated in vitro to define the limits of the 35 kDa open reading frame. A second, small open reading frame capable of encoding a polypeptide of 4.9 kDa was also indicated from the sequence; however, there was no evidence for a protein product of that size. RNA-2 is presumed to be monocistronic and encode a cell-to-cell movement function. A small but significant amino acid sequence homology was observed with the brome mosaic virus RNA-3a polypeptide.
Synthesis and Bioactivity Profile of 5-S-Lipoylhydroxytyrosol-Based Multidefense Antioxidants with a Sizeable (Poly)sulfide Chain (2012)

Novel polyfunctionalized antioxidants, 5-S-lipoylhydroxytyrosol (1) and its disulfide 2, trisulfide 3, and tetrasulfide 4, were prepared from tyrosol and dihydrolipoic acid in the presence, when appropriate, of sulfur. Compound 1 exhibited significant activity in the ferric reducing/antioxidant power (FRAP) assay (1.60 Trolox equiv), whereas polysulfides 2-4 were more efficient in the DPPH reduction assay (88-93% reduction vs 68% by Trolox). At 10 μM concentration, all compounds 1-4 proved to be efficient hydroxyl radical scavengers (56-69% inhibition) in a Fenton reaction assay. When administered to human HepG2 cells, 1-4 proved to be nontoxic and exhibited marked protective effects against reactive oxygen species (ROS) generation (60-84% inhibition at 1 μM concentration) and cell damage induced by 400 μM tert-butylhydroperoxide. All compounds 1-4 exhibited overall greater antioxidant activity than hydroxytyrosol.
HIV Seroprevalence in Newborns in New York State (1989)

The prevalence of human immunodeficiency virus (HIV) infection was determined in women at the time of childbirth throughout New York State between November 30, 1987, and November 30, 1988. Mandatory blood specimens (276,609) obtained from all newborns were examined for HIV. The overall HIV seroprevalence rate was 0.66% (1816 newborns), with 0.16% in Upstate New York and 1.25% in New York City. Rates for newborns whose mothers were aged 20 to 29 years (1.30%) and 30 to 39 years (1.35%) were significantly higher than rates for those with mothers younger than 20 years of age (0.72%). Rates of seropositivity were higher among blacks (1.8%) and Hispanics (1.3%) than among whites (0.13%). Seropositivity of HIV was higher in zip code areas with high rates of drug use (2.2%) than in the rest of New York City (0.8%). It is estimated that more than 726 HIV-infected children were born in New York State during the 1-year study period, using 40% as the probable proportion of seropositives that will become infected.
Evidence for cytoskeleton implication in cell electropermeabilization and electrofusion (1991)

Permeabilization of the plasma membrane of Chinese hamster ovary cells by application of external electric field pulses can be described as a three step process of induction, expansion and annihilation of transient permeated structures. This phenomenon is associated to an increase in microvilli, density at the cell surface. In the case of cells into contact, the resealing of the permeated state can lead to the formation of polycaryons to which is associated to a reorganisation of microtubules into the cells. This observation shows an alteration of the cytoskeleton organization as a consequence of cell electropulsation. Annihilation of the permeated state depends on several physical parameters of the technique, but, in opposition to the two first steps of induction and expansion, it appears to be under the control of the cytoskeleton.These results suggest that microtubules play an important role in the process. Although it is still difficult to describe the exact role of the cytoskelteon in electropermeabilization, its interaction with plasma membrane makes it a candidate as a regulatory element.
Surgical Management of Osteoradionecrosis of the Temporal Bone (1988)

The surgical management of osteoradionecrosis of the temporal bone has met with limited success because of the difficulty in accurate assessment of the viability of nonnecrotic bone intraoperatively. Failure to resect all nonviable bone results in recurrence of a necrotic focus. With the use of hyperbaric oxygen therapy to stabilize marginal bone and oral tetracycline to label viable bone preoperatively, removal of all nonviable bone can be accomplished. Postoperatively, a second course of hyperbaric therapy enhances wound healing, thus assuring a successful outcome. This article details a successful systematic approach that was developed to resect a necrotic focus in the temporal bone of a 10-year-old boy who had undergone a full course of radiotherapy for treatment of a rhabdomyosarcoma.
Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla (2011)

The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro againstU251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), β-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 µg/mL), with exception of NCI-H460 cell line (TGI 191.31 µg/mL). The highest activity was observed against UACC-62 (TGI 7.30 µg/mL), and K562 (TGI 7.56 µg/mL) cell lines. The observed activity could be related to high content of germacrene D and β-caryophyllene, compounds known as cytotoxic.
Reduction of the hand representation in the ipsilateral primary motor cortex following unilateral section of the corticospinal tract at cervical level in monkeys (2005)

After cervical hemi-section, the ipsilesional motor cortex exhibited substantial reduction of the hand representation, whose extent did not match the small number of axotomized CS neurons. We hypothesized that the paradoxical reduction of hand representation in the ipsilesional hemisphere is secondary to the changes taking place in the contralesional hemisphere, possibly corresponding to postural adjustments and/or re-establishing a balance between the two hemispheres.
Adsorption Chromatography of Nucleic Acids on Silicone-Coated Porous Glass (1983)

Bovine liver tRNA was adsorbed on silicone-coated porous glass in 5 M NaCl, 10 mM Tris-HCl (pH 7.6) and fractionated by elution with decreasing NaCl concentrations. tRNAPro, tRNAVal, tRNAIle, tRNAThr, tRNASer, and tRNAPhe were eluted in this order. tRNA which had been digested with ribonuclease A was not adsorbed. Q beta RNA (adsorbed onto the glass in 5 M NaCl) was eluted with 1.5 M NaCl. RNA species in a crude rRNA fraction from Escherichia coli were separated into tRNA, 5S rRNA, and high molecular weight rRNA on siliconized porous glass. A half of calf thymus DNA was adsorbed on the glass in 5 M NaCl and the residual part passed through the column. The CD spectra showed that DNA and tRNA took the C-form and the A-form in 5 M NaCl, respectively. Therefore, the discrepancies of behavior of the DNA and RNA on siliconized porous glass may be related to the occurrence of these forms. The recovery of these nucleic acids from the column was 83-100%. Adsorption chromatography on siliconized porous glass may be a useful method for the separation of tRNA, rRNA, and mRNA.