gebhart/patrepeval huggingface dataset:
Synthesis of related forms of the lysosomal enzyme alpha-mannosidase in Dictyostelium discoideum. (1983)

Purified lysosomal alpha-mannosidase from the cellular slime mold, Dictyostelium discoideum, is composed of two subunits of Mr = 58,000 and 60,000 as revealed by polyacrylamide gel electrophoresis under denaturing conditions. The pattern of peptide fragments produced when these two species are digested with proteases indicates that they are related but not identical. Using monoclonal antibodies prepared against purified alpha-mannosidase, we have analyzed the different forms of the enzyme synthesized in vivo. In addition to two bands that co-migrate with the pure enzyme, a large Mr (140,000) species is found in immunoprecipitated [35S] methionine-labeled extracts of cellular and secreted proteins. The precipitation of all three bands is inhibited by preadsorption of the antibodies with pure enzyme and all three proteins are absent in extracts of an alpha-mannosidase structural gene mutant. One-dimensional peptide maps indicate that all sequences present in the smaller species are found in the Mr = 140,000 form. In addition, the large form accounts for about 20% of the extracellular alpha-mannosidase activity secreted by amoebae during growth in axenic culture. These results lead to the conclusion that alpha-mannosidase is first synthesized as a large enzymatically active precursor which is modified and proteolytically cleaved to form the smaller subunits.
[Interactions between electrical activities of the sensomotor cortex and the hippocampus during 'animal hypnosis' in rabbits]. (2000)

The electrical activity of the left and right sensorimotor cortex and left and right dorsal hippocampus (CA3 fields) was recorded during "animal hypnosis" in rabbits. The "animal hypnosis" produced asymmetry in the spectral power of the hippocampal electrical activity due to an increase in the power of delta 1, delta 2, and theta 1 components in the left-hippocampus and decrease in the spectral power in the same ranges in the right-hippocampus. Hemispheric asymmetry in the electrical activity during the "animal hypnosis" was also expressed in the indices of coherence between the sensorimotor cortex and hippocampus. EEG coherence between the left sensorimotor cortex and left hippocampus in the delta 1, theta 1, and theta 2 ranges was higher than that between the right-side structures.
Type‐specific localization of monoamine oxidase in the enteric nervous system: Relationship to 5‐hydroxytryptamine, neuropeptides, and sympathetic nerves (1990)

The localization in the guinea pig enteric nervous system (ENS) of monoamine oxidase (MAO) types A and B was investigated at the light and electron microscopic levels. Immunocytochemistry was used to visualize the enzyme protein and histochemistry was employed to study catalytic activity. Type specificity was achieved in histochemical studies by using deprenyl (0.5 microM) to inhibit MAO-B or clorgyline (0.1 microM) to inhibit MAO-A. The distribution of MAO-B immunoreactivity in the ENS corresponded to that of the sites of MAO activity found histochemically to be inhibited by deprenyl, but not clorgyline. MAO-B was observed to be the primary type of MAO found in the intrinsic elements of the ENS and was located in subsets of neurons in both submucosal and myenteric plexuses. MAO-B was not demonstrated immunocytochemically or histochemically in enteric glia, nor, at the light microscopic level, was there significant MAO-B activity or immunoreactivity in serotonin (5-HT)-immunoreactive neuronal cell bodies. In the submucosal plexus about 50% of the neurons expressed MAO-B; these neurons also contained neuropeptide y (NPY) and/or calcitonin gene related peptide (CGRP), but not substance P or vasoactive intestinal polypeptide (VIP). About 10% of myenteric neurons were intensely reactive for MAO-B; again MAO-B was co-localized with NPY and/or CGRP. In contrast to intrinsic neurons, extrinsic CGRP-immunoreactive nerve fibers contained no demonstrable MAO activity or immunoreactivity. Moreover, the sympathetic innervation, identified as varicose axons that degenerated after administration of 6-hydroxydopamine, contained abundant MAO-A, but no MAO-B activity or immunoreactivity. It is concluded that MAO-B is characteristic of a subset of intrinsic enteric neurons, while MAO-A is confined to the sympathetic innervation, which is extrinsic. At the electron microscopic level individual cells varied greatly in their degree of immuno- or cytochemically demonstrable MAO-B, which was most concentrated on the outer membranes of mitochondria. MAO-B immunoreactivity (but not cytochemical activity) was found on mitochondria in some serotoninergic perikarya identified by the simultaneous radioautographic detection of the uptake of 3H-5-HT. Mitochondria in most serotoninergic axon terminals displayed both MAO-B activity and immunoreactivity. Neurons receiving serotoninergic synapses often, but not invariably, contained MAO-B. Inhibition of neither MAO-B nor MAO-A appeared to slow the disappearance of 3H-5-HT loaded into enteric neurons significantly, even when intraneuronal storage of 5-HT was inhibited with tetrabenazine.(ABSTRACT TRUNCATED AT 400 WORDS)
Synthesis of Ag@Polycarbazole Nanocomposite using Ferric Acetate as an Oxidant (2020)

Silver nanowires and Ag@polycarbazole nanocables have been effectively fabricated. Polyol-reduction and ion adsorption process were used to fabricate pure silver nanowires and Ag@polycarbazole nanocomposite by using an oxidant (iron acetate). Ions of oxidant were adsorbed on the surface of pure silver nanowires to oxidize carbazole monomers for efficient polymerization. The morphology of nanowires and Ag@PCz composite were characterized by using SEM, FT-IR and photoluminescence analysis. The SEM shows the presence of a smooth polymeric sheath. FT-IR and photoluminescence analysis shows dominant peaks that indicate the presence of silver nanowires and polycarbazole (PCz) with a smooth polymeric coating. Nanoparticle analyzer was used to determine z-average and actual size of sample. UV-visible spectrum shows two bands that were dominant at 345 and 410 nm. These are π to π* transitions that indicates the presence of polycarbazole nanocables.
Progress of Traditional Chinese Medicine Treating Chronic Atrophic Gastritis (2013)

Chronic atrophic gastritis(CAG)is a common chronic disease.Due to its ease of intestinal metaplasia and atypical hyperplasia of gastric cancer,it is closely related to the occurrence.WHO has made its positioning as a precancerous condition of gastric mucosa.Therefore,prevention and treatment of the disease by blocking its carcinogenesis has become a hot topic of research of traditional Chinese medicine and Western medicine.In recent years,traditional Chinese medicine syndrome differentiation and treatment of CAG in clinical and experimental studies have made some progress,showing some advantages.This article summarized CAG from the pathogenesis,clinical and experimental study on TCM treatment.
Clinical Responses Following Periodontal Treatment by Local Drug Delivery (1985)

A 4-quadrant, single-blind study was designed to test the efficacy of periodontal disease therapy by local drug delivery. A delivery system made of extruded ethylene vinyl acetate fibers loaded with 25% USP tetracycline hydrochloride was placed and maintained in periodontal pockets for 10 days. The clinical effects of this form of therapy were compared with treatment by periodontal scaling. In addition, the effect of treatment by combined local delivery and scaling was investigated. Untreated quadrants were included as control. Placement of tetracycline-loaded ethylene vinyl acetate fibers into periodontal pockets established a drug concentration of approximately 0.06%. By covering the delivery system with a periodontal dressing, this concentration level was maintained throughout the 10-day therapeutic period. The average tetracycline dose used was 2.4 mg/tooth treated. Following fiber therapy, treated sites improved clinically, as evidenced by a gain in periodontal attachment and a decrease in periodontal pocket depth. The rate of new lesion formation at fiber-treated sites decreased from a pretreatment rate of 26.5% of sites/year to a posttreatment rate of 4.8% of sites/year. Periodontal scaling also produced clinical improvement, as indicated by significant attachment gain, pocket depth reduction and a decreased rate of new lesion formation. However, in no case were clinical results by scaling superior to results by local drug delivery, and by several measures local drug delivery was found to provide a better clinical response. Principal measures by which the clinical response using local drug delivery exceeded that by scaling were in early (3-6 months) attachment gain and in the degree of reduction of new lesion formation. The combination of fiber therapy with scaling reduced the rate of new lesion formation; however, attachment gain appeared delayed in comparison with either scaling alone or fiber therapy alone. This delay in healing was probably due to mechanical interference by the delivery system, which was packed into the periodontal pocket immediately following scaling. Although delayed, the final attachment gain was equal to that of other treatment modalities. Untreated sites exhibited clinical signs of significant improvement which appeared 6 to 12 months after the therapeutic period. Attachment level gains were consistently less than at periodontal sites which had been treated but were nevertheless significant when compared to pretreatment levels. It is suggested that host response mechanisms triggered by periodontal scaling may have been responsible for this effect.
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills (2018)

The hydroalcoholic extract obtained from wild-growing Juniperus communis native to Romanian southern sub-Carpathian hills has genoprotective, antioxidant, antifungal and anti-inflammatory properties.
Facile Synthesis of Cyclic Peptide–Phthalocyanine Conjugates for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy (2021)

A facile procedure for in situ peptide cyclization and phthalocyanine conjugation was developed by utilizing a bifunctional linker incorporated with a bis(bromomethyl)benzene unit and a cyclopentadiene moiety. These functional groups facilitated the nucleophilic substitution with the two cysteine residues of the linear peptides followed by the Diels-Alder reaction with the maleimide moiety attached to a zinc(II) phthalocyanine. With this approach, three cyclic peptide-phthalocyanine conjugates were prepared in 20-26% isolated yield via a one-pot procedure. One of the conjugates containing a cyclic form of the epidermal growth factor receptor (EGFR)-binding peptide sequence CMYIEALDKYAC displayed superior features as an advanced photosensitizer. It showed preferential uptake by two EGFR-positive cancer cell lines (HT29 and HCT116) compared with two EGFR-negative counterparts (HeLa and HEK293), resulting in significantly higher photocytotoxicity. Intravenous administration of this conjugate into HT29 tumor-bearing nude mice resulted in selective localization in tumor and effective inhibition of tumor growth upon photodynamic treatment.
Face detection from color images using a fuzzy pattern matching method (1999)

This paper describes a new method to detect faces in color images based on the fuzzy theory. We make two fuzzy models to describe the skin color and hair color, respectively. In these models, we use a perceptually uniform color space to describe the color information to increase the accuracy and stableness. We use the two models to extract the skin color regions and the hair color regions, and then comparing them with the prebuilt head-shape models by using a fuzzy theory based pattern-matching method to detect face candidates.
Financial Programming and Policy: The Case of Sri Lanka (1996)

This book, by a staff team in the IMF Institute, contains a series of workshops that introduce the process of formulating a hypothetical macroeconomic and structural adjustment program, which is a central element in the financial programming courses offered by the IMF Institute. In addition to elaborating key concepts for the four major sectoral accounts, the workshops are designed to allow the development of a step by step reference scenario for Sri Lanka
Regulation of Herpesvirus Macromolecular Synthesis: Evidence for Multilevel Regulation of Herpes Simplex 1 RNA and Protein Synthesis (1974)

The choice of herpes simplex virus for analyses of regulation of viral macromolecular metabolism in mammalian cells stems from two considerations. The first is that the general pattern of viral metabolism mimics events in uninfected cells. Thus viral DNA is replicated and transcribed in the nucleus, and the transcripts are processed both by cleavage and adenylation prior to transport into the cytoplasm. Viral polypeptides are made in cytoplasmic-free and -bound polyribosomes (Sydiskis and Roizman 1966, 1967) and differ widely in their function. Some are transported into the nucleus (Olshevsky et al. 1967; Roizman and Spear 1968), others are incorporated into the cellular membranes, become glycosylated and, at least in part, form the specialized membranes which envelop the virus (Spear et al. 1970; Spear and Roizman 1970; Roizman 1971). In many respects, the above processes superficially appear to follow the course of analogous events in uninfected cells. Since viral macromolecules are...
Domain Adaptation For Formant Estimation Using Deep Learning (2016)

In this paper we present a domain adaptation technique for formant estimation using a deep network. We first train a deep learning network on a small read speech dataset. We then freeze the parameters of the trained network and use several different datasets to train an adaptation layer that makes the obtained network universal in the sense that it works well for a variety of speakers and speech domains with very different characteristics. We evaluated our adapted network on three datasets, each of which has different speaker characteristics and speech styles. The performance of our method compares favorably with alternative methods for formant estimation.
Pressure drop across artificially induced stenoses in the femoral arteries of dogs. (1975)

Stenoses were artificially induced in 13 large mongrel dogs by implanting small hollow cylindrical plugs in their femoral arteries. The instantaneous pressure drop across the stenosis and the flow rate were measured for a series of stenoses varying in severity from 52.3 to 92.2%. Mean pressure drops ranged from approximately 2 to 30 mm Hg with peak pressure drops ranging from 9 to 53 mm Hg. The pressure drop could be estimated from a relatively simple equation that was originally developed for flow through model stenoses. With this equation, the effects of several factors that contribute to the pressure drop, including stenosis size and shape, artery lumen diameter, blood density, blood viscosity, and velocity and acceleration of flow, could be clearly delineated. For severe stenoses, unsteady flow effects were small and flow could be treated as quasi-steady. Calculations based on data obtained from the dog experiments revealed that the mean pressure drop across a stenosis increased nonlinearly with percent stenosis and showed quantitatively that the value of critical stenosis decreased with increasing demand for blood flow.
Osmotically inactive skin Na + storage in rats (2003)

Compared with age-matched men, women are resistant to the hypertensive effects of dietary NaCl; however, after menopause, the incidence of salt-sensitive hypertension is similar in women and men. We recently suggested that osmotically inactive Na+ storage contributes to the development of salt-sensitive hypertension. The connective tissues, including those immediately below the skin that may serve as a reservoir for osmotically inactive Na+ storage, are affected by menopause. We tested the hypothesis that ovariectomy (OVX) might reduce osmotically inactive Na+ storage capacity in the body, particularly in the skin. Male, female-fertile, and female OVX Sprague-Dawley (SD) rats were fed a high (8%)- or low (0.1%)-NaCl diet. The groups received the diet for 4 or 8 wk. At the end of the experiment, subgroups received 0.9% saline infusion and urinary Na+ and K+ excretion was measured. Wet and dry weight (DW), water content in the body and skin, total body Na+ (rTBNa+) and skin Na+ (rSKNa+) content were measured relative to DW by desiccation and dry ashing. There were no gender differences in osmotically inactive Na+ storage in SD rats. All SD rats accumulated Na+ if fed 8% NaCl, but rTBNa+ was lower in OVX rats than in fertile rats on a low (P < 0.001)- and a high (P < 0.05)-salt diet. OVX decreased rSKNa+ (P < 0.01) in the rats. A high-salt diet led to Na+ accumulation (DeltaSKNa+) in the skin in all SD rats. Osmotically inactive skin Na+ accumulation was approximately 66% of DeltaSKNa+ in female and 82% in male-fertile rats, but there was no osmotically inactive Na+ accumulation in OVX rats fed 8% NaCl. We conclude that skin is an osmotically inactive Na+ reservoir that accumulates Na+ when dietary NaCl is excessive. OVX leads to an acquired reduction of osmotically inactive Na+ storage in SD rats that predisposes the rats to volume excess despite a reduced Na+ content relative to body weight.
Data Protection and Computer Misuse Act Reference List (2010)

This is the reference lists for the resource set we have produced for the INFO2009 Assignment 2 Group Poster.
Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation (1981)

Micropuncture studies were performed in three groups of male Munich-Wistar rats 1 wk after surgery: group I, eight control rats that underwent laparotomy and were fed a normal diet; group II, nine rats that underwent right nephrectomy and segmental infarction of five-sixths of the left kidney and were fed a normal diet; and group III, seven rats that underwent the same renal ablative procedure and were fed a low protein diet. Single nephron glomerular filtration rate (SNGFR) was higher in the remnant kidney of group II rats compared with group I rats due to higher average values for mean glomerular transcapillary hydraulic pressure difference (delta P) and initial glomerular plasma flow rate (QA) in group II. Glomeruli in remnant kidneys of group II showed striking alterations in morphology, including epithelial cell protein reabsorption droplets, foot process fusion, and mesangial expansion. Group III rats demonstrated a mean SNGFR not statistically different from that of group I, but significantly less than that of group II rats. This lack of absolute hyperfiltration in remnant glomeruli of group III rats relative to group I obtained because QA and delta P did not increase above values found in group I. The glomerular structural lesions seen in group II were also largely attenuated in group III. These studies demonstrate that alterations in glomerular hemodynamics associated with renal ablation are accompanied by structural lesions and suggest that sustained single nephron hyperfiltration may have maladaptive consequences by damaging remnant glomeruli.
Tuning the spin-related transport properties of FePc on Au(111) through single-molecule chemistry (2018)

Tuning the spin-dependent electron transport through molecules is of fundamental importance in single-molecule spintronics. Here, the transport properties of iron phthalocyanine on Au(111) was investigated by a combination of scanning tunneling microscopy and density functional theory calculations. Using high-resolution scanning tunneling spectroscopy performed at 0.5 K, a Kondo resonance was observed on FePc. After removing its eight outermost hydrogen atoms, the spectroscopic feature changed into a double-step structure, which reflected inelastic transitions of molecular spin states. The density functional theory calculations revealed that the coupling between Fe and Au(111) became much weaker after cutting the hydrogen atoms. This explained the change of the spin-related fingerprints in the differential spectra.
Energy level evolution of molybdenum trioxide interlayer between indium tin oxide and organic semiconductor (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Irfan, Huanjun Ding, Yongli Gao, Do Young Kim, Jegadesan Subbiah, Franky So; Energy level evolution of molybdenum trioxide interlayer between indium tin oxide and organic semiconductor. Appl. Phys. Lett. 15 February 2010; 96 (7): 073304. https://doi.org/10.1063/1.3309600 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Target tracking using fuzzy logic association (2002)

Multistatic active sonar systems are being developed for the mission of tracking enemy submarines in harsh underwater environments. This paper focuses on a revolutionary new method with which to track a target. A fuzzy logic based tracker has been developed which performs remarkably better than a Kalman filter tracker. This is accomplished through the use of additional, non-kinematic information about each of the detections. The fuzzy logic engine combines these additional clues with the kinematic clues. This framework allows for the implementation of user-designed rules which take advantage of the additional information that is provided as input to the tracker. This additional information, effectively handled, yields a significant improvement in tracker performance.
Development of a wireless intra-ocular pressure monitoring system for incorporation into a therapeutic glaucoma drainage implant (2008)

Glaucoma is a common cause of blindness. Wireless, continuous monitoring of intraocular pressure (IOP) is an important, unsolved goal in managing glaucoma. An IOP monitoring system incorporated into a glaucoma drainage implant (GDI) overcomes the design complexity associated with incorporating a similar system in a more confined space within the eye. The device consists of a micro-electro-mechanical systems (MEMS) based capacitive pressure sensor integrated with an inductor printed directly onto a polyimide printed circuit board (PCB). The device is designed to be incorporated onto the external plate of a therapeutic GDI. The resonance frequency changes as a function of IOP, and is tracked remotely using a spectrum analyzer. A theoretical model for the reader antenna was developed to enable maximal inductive coupling with the IOP sensor implant. Pressure chamber tests indicate that the sensor implant has adequate sensitivity in the IOP range with excellent reproducibility over time. Additionally, we show that sensor sensitivity does not change significantly after encapsulation with polydimethylsiloxane (PDMS) to protect the device from fluid environment. In vitro experiments showed that the signal measured wirelessly through sheep corneal and scleral tissue was adequate indicating potential for using the system in human subjects.