gebhart/patrepeval huggingface dataset:
Abstract 1421: Interleukin-22, a protective factor for ovarian cancer during TNFa-induced apoptosis. (2013)

Abstract Ovarian cancer is the 5th leading cause of death from cancer in women. Overall, only 10% of patients with advanced ovarian cancer are curable; despite the advances in chemotherapy the 5-year survival is still less than 30%. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines is part of the innate immune system and is expressed by the Th17 cells. IL-22 has been shown to regulate several processes such as the acute-phase response, activation of the innate immune system, cell migration, differentiation and gene expression. However, its role in cancer immunology, especially in ovarian cancer has not been studied. The aim of this study is to investigate the expression and the role IL-22 in human ovarian cancer. In our work, we analyzed the expression of IL-22 protein in human ovarian cancer tissues and ascites samples using immunohistochemistry and ELISA; we tested the expression of IL-22 receptor on human ovarian cancer cells via Western Blot, and determined the association between disease outcome and IL-22 gene expression (Affymetrix)in patients with human ovarian cancer. We evaluated the effect of IL-22 on cellular proliferation using MTT assay and we assessed the effect of IL-22 on TNF-a induced apoptosis using caspase 3/7 activity (Caspase Glo) assay and 7AAD staining on multiple human ovarian cancer cell lines. Here we demonstrate that IL-22 was expressed in human ovarian cancer tissue (mostly in the stroma) and that the receptor for IL-22 was expressed on human ovarian cancer cells. We found that high expression of IL-22, as well as the IL-22-receptor in the tumor tissue leads to poor disease outcome in ovarian cancer patients. On the contrary, high expression of IL-22-binding protein (antagonist of IL-22) was associated with better survival in ovarian cancer patients. We showed that treatment with human recombinant (hr) IL-22 protein induced the activation of Stat-3, as well as increased the proliferation of human ovarian cancer cell lines. We also found that treatment with hr IL-22 at 100, 50 or even at 10 ng/mL concentrations inhibited TNF-a induced apoptosis in OVCAR-5 ovarian cancer cell line, and these results were reversed by the addition of IL22 binding protein to the culture. We conclude that interleukin-22 is an important factor in the tumor microenvironment of ovarian cancer; it promotes tumor growth by increasing proliferation and serves as a protective factor for ovarian cancer during TNF-s induced apoptosis. These data suggest that IL-22 is a potential therapeutical target and/or biomarker in human ovarian cancer. Citation Format: Klara Balint, Tamara Seedial, Phyllis Gimotty, George Coukos, Andrea Facciabene. Interleukin-22, a protective factor for ovarian cancer during TNFa-induced apoptosis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1421. doi:10.1158/1538-7445.AM2013-1421
PHASE II DRUG METABOLIZING ENZYMES (2010)

Phase II drug metabolizing enzymes play an important role in biotransformation of endogenous compounds and xenobiotics to more easily excretable forms as well as in the metabolic inactivation of pharmacologically active compounds. Reduced metabolising capacity of Phase II enzymes can lead to toxic effects of clinically used drugs. Gene polymorphism/ lack of these enzymes may often play a role in several forms of cancer.
Occult ventriculo -atrial shunt infection: a forgotten condition (2005)

Background For some time after introduction of the Holter valve, shunting for hydrocephalus was ventriculo – atrial (VA). Features of infection in ventriculoperitoneal (VP) and VA shunts differ considerably, and lack of familiarity of the latter has led to inappropriate referral and incorrect diagnosis and treatment. We present a recent illustrative case with new microbiological findings and re – emphasise the diagnostic criteria.
A coded bit-loading linear precoded discrete multitone solution for power line communication (2008)

Linear precoded discrete multitone modulation (LP-DMT) system has been already proved advantageous with adaptive resource allocation algorithm in a power line communication (PLC) context. In this paper, we investigate the bit and energy allocation algorithm of an adaptive LP-DMT system taking into account the channel coding scheme. A coded adaptive LP-DMT system is presented in the PLC context with a loading algorithm which accommodates the channel coding gains in bit and energy calculations. The performance of a concatenated channel coding scheme, consisting of an inner Wei’s 4-dimensional 16-states trellis code and an outer Reed-Solomon code, in combination with the proposed algorithm is analyzed. Simulation results are presented for a fixed target bit error rate in a multicarrier scenario under power spectral density constraint. Using a multipath model of PLC channel, it is shown that the proposed coded adaptive LP-DMT system performs better than classical coded discrete multitone.
A real-time system for tele-surgery (2002)

Describes a real-time system supporting a tele-surgery application based on the Zeus/sup TM/ system. The application involves performing minimally invasive surgical procedures remotely - i.e. without the surgeon being present in the same room with the patient. Because there is human life at stake, the underlying real-time system must be robust, fail-safe and resilient to communications problems. This paper focuses primarily on the approach taken in communicating between the surgeon-side and patient-side subsystems. In particular, techniques for dealing with the challenges of real-time communications are discussed, e.g. bit errors, packet errors and synchronization. In addition to the control actions and feedback data, several serial data streams are multiplexed, transmitted between one side and the other, demultiplexed, and delivered by the real-time system. These streams have a fundamentally different character from the control actions and feedback values used with the robots. Both types of real-time streams are sent over the same communications link.
Echolocation detection of fishing hooks and implications for the Hawaiian longline fishery (2016)

Interactions between marine mammals and fisheries have a biological and economic impact that is often detrimental to both fishermen and species of concern. False killer whale bycatch in the Hawaii longline fishery has exceeded the potential biological removal (PBR) triggering the designation of a take reduction team under the Marine Mammal Protection Act (MMPA). As an attempt to understand the importance of acoustic cues in depredation events, this study presents preliminary data looking at the echolocation ability of a false killer whale (Pseudorca crassidens) to detect a longline fishing hook at various distances. Using a go/no-go paradigm, the whale was trained to report the presence of the hook at distances varying in 50 cm increments. A total of 28 sessions of 25 trials each were collected and echolocation signals were recorded using a nine element acoustic array. Number of clicks, acoustic parameters, decision time and performance were recorded. The subject successfully reported the presence of the hook up to 6 m. This work presents evidence that false killer whales can easily detect fishing gear which could influence how they interact with longline fishery.
Psychological Injury in the Workplace (2008)

The article addresses the issue of work-related psychological injury in Australia through a review of newer developments in the field. In addition, it explores research on various initiatives in prevention, early intervention and return to work management. It acknowledges the vital role played by evidence-based psychological interventions in injury prevention and improved health and return to work outcomes.
A collision free data link layer protocol for wireless sensor networks and its application in intelligent transportation systems (2009)

Vehicular networks are the major ingredients of the envisioned intelligent transportation systems (ITS) concept. An important component of ITS which is currently attracting wider research focus is road traffic monitoring. The actual approaches for traffic road monitoring are characterized by longer response times and are also subject to higher processing requirements and possess high deployment costs. In this paper, we propose a completely distributed and scalable mechanism for wireless sensor network-based road traffic monitoring. The approach relies on the distributed and bidirectional exchange of traffic information between the vehicles traversing the routes and a miniature cluster head and takes into consideration both the security and reliability of data communication. In addition, the communication between nodes is collision free since the underlined data link layer protocol relies on a heuristic time multiplexed-based protocol. The performance analysis shows that the proposed mechanism usually outperforms other algorithms for different traffic densities.
Morphological changes of the surface structure of polymers due to excimer laser radiation: A synergetic effect? (1989)

Excimer-laser-induced ablation of polymers is often accompanied by a modification of the surface morphology at the irradiated regions. Only very recently models have been proposed for this effect, the origin being searched in different absorption properties of crystalline and amorphous material. A study by the authors on synthetic fibers irradiated by the UV laser is in contrast with that assumption and gave evidence of a thermal contribution to laser-polymer interaction. Furthermore, a strong influence of internal or external stress fields is found. On this basis a synergetic understanding of the surface structures is proposed.
Multiple Gene Deletion in Cryptococcus neoformans Using the Cre–lox System (2012)

Reverse genetics is commonly used to identify and characterize genes involved in a variety of cellular processes. There is a limited set of positive selectable markers available for use in making gene deletions or other genetic manipulations in Cryptococcus neoformans. Here, we describe the adaptation of the Bacteriophage P1 Cre-loxP system for use in C. neoformans, and its application in the excision and reuse of the geneticin drug marker. This tool will allow investigators to make multiple, sequential gene deletions in the same strain, which should facilitate the analysis of multigene families.
Elucidating Molecular Motion through Structural and Dynamic Filters of Energy-Minimized Conformer Ensembles (2014)

ABSTRACT: Complex RNA structures are constructed from helical segments connected by flexible loops that move spontaneously and in response to binding of small molecule ligands and proteins. Understanding the conformational variability of RNA requires the characterization of the coupled time evolution of interconnected flexible domains. To elucidate the collective molecular motions and explore the conformational landscape of the HIV-1 TAR RNA, we describe a new methodology that utilizes energy-minimized structures generated by the program “Fragment Assembly of RNA with Full-Atom Refinement (FARFAR)”. We apply structural filters in the form of experimental residual dipolar couplings (RDCs) to select a subset of discrete energy-minimized conformers and carry out principal component analyses (PCA) to corroborate the choice of the filtered subset. We use this subset of structures to calculate solution T1 and T1ρ relaxation times for 13C spins in multiple residues in different domains of the molecule using two simulation protocols that we previously published. We match the experimental T1 times to within 2 % and the T1ρ times to within less than 10 % for helical residues. These results introduce a protocol to construct viable dynamic trajectories for RNA molecules that accord well with experimental NMR data and support the notion that the motions of the helical portions of this small RNA can be described by a relatively small number of discrete conformations exchanging over time scales longer than 1 μs. 1.
Two Phase Non-Rigid Multi-Modal Image Registration Using Weber Local Descriptor-Based Similarity Metrics and Normalized Mutual Information (2013)

Non-rigid multi-modal image registration plays an important role in medical image processing and analysis. Existing image registration methods based on similarity metrics such as mutual information (MI) and sum of squared differences (SSD) cannot achieve either high registration accuracy or high registration efficiency. To address this problem, we propose a novel two phase non-rigid multi-modal image registration method by combining Weber local descriptor (WLD) based similarity metrics with the normalized mutual information (NMI) using the diffeomorphic free-form deformation (FFD) model. The first phase aims at recovering the large deformation component using the WLD based non-local SSD (wldNSSD) or weighted structural similarity (wldWSSIM). Based on the output of the former phase, the second phase is focused on getting accurate transformation parameters related to the small deformation using the NMI. Extensive experiments on T1, T2 and PD weighted MR images demonstrate that the proposed wldNSSD-NMI or wldWSSIM-NMI method outperforms the registration methods based on the NMI, the conditional mutual information (CMI), the SSD on entropy images (ESSD) and the ESSD-NMI in terms of registration accuracy and computation efficiency.
Improved SIV DNA vaccine can be effectively used as a boost for Ad5 in prime–boost immunization strategy (2012)

In the study under evaluation, optimized SIV DNA were used to boost T-cell responses induced by a highly immunogenic SIV Ad5-prime in Chinese rhesus macaques. A regular prime-boost regimen (SIV DNA-prime and rAd boost) and naive macaques were used as the control. After vaccination, the animals were challenged intrarectally with SIVmac251, and partial protection was observed in the macaques immunized by the Ad5-prime DNA-boost regimen. SIV-specific T-cell responses in the enzyme-linked immunospot assay were significantly higher in the Ad5-prime DNA-boost, compared with the responses in the control macaques. Viral control correlated with the generation of HLA-DR+ T cells 2 weeks after the viral challenge. Further studies using prime and boost strategies and alternative routes of vaccination (including a simultaneous approach) are warranted to fully explore the potential of prime and boost regimens for HIV-1 vaccine development.
Photoreceptor cell death by apoptosis in dogs with sudden acquired retinal degeneration syndrome. (1998)

Because apoptosis appears to be a final common pathway in many retinal degeneration syndromes, future treatment strategies that control apoptosis in other diseases may be applicable to dogs with SARDS. Halting this pathway may allow some photoreceptors to survive and, perhaps, preserve vision.
Launching the revenue rocket How revenue management can work for your business (1997)

Revenue management (RM) is the application of disciplined tactics that predict consumer behavior at the micromarket level and optimize product availability and price to maximize revenue growth. While the application of RM principles depends on each company's competitive situation, the process is similar for all firms. Each firm should examine the applicability of RM to its situation, and specifically if its market is characterized by vagaries of demand, a perishable product (e.g., hotel rooms, restaurant meals), and strong competition. The firm's management should use data-analysis techniques to estimate untapped revenue potential. This estimate involves analyzing all available data to uncover hidden revenue potential through the computerized emulation of actual business environments and control processes. Finally, the firm should quantify the benefits of revenue management. Those responsible for managing revenue should be given express control over all revenue-generating functions, and top management should allow those revenue managers the leeway to make constant and rapid changes in the price and product mix. In the final analysis, revenue management allows a firm to create new time-based products on the spot, as customer demand for those products becomes apparent.
Test-beam studies of a small-scale TORCH time-of-flight demonstrator (2020)

TORCH is a time-of-flight detector designed to perform particle identification over the momentum range 2–10 GeV/c for a 10 m flight path. The detector exploits prompt Cherenkov light produced by charged particles traversing a quartz plate of 10mm thickness. Photons are then trapped by total internal reflection and directed onto a detector plane instrumented with customised position-sensitive Micro-Channel Plate Photo-Multiplier Tube (MCP-PMT) detectors. A single-photon timing resolution of 70ps is targeted to achieve the desired separation of pions and kaons, with an expectation of around 30 detected photons per track. Studies of the performance of a small-scale TORCH demonstrator with a radiator of dimensions 120×350×10mm3 have been performed in two test-beam campaigns during November 2017 and June 2018. Single-photon time resolutions ranging from 104.3ps to 114.8ps and 83.8ps to 112.7ps have been achieved for MCP-PMTs with granularity 4 × 64 and 8 × 64 pixels, respectively. Photon yields are measured to be within ∼10% and ∼30% of simulation, respectively. Finally, the outlook for future work with planned improvements is presented.
Monoclonal and anti-idiotypic anti-EBV/C3d receptor antibodies detect two binding sites, one for EBV and one for C3d on glycoprotein 140, the EBV/C3dR, expressed on human B lymphocytes. (1988)

Glycoprotein (gp) 140, the EBV/C3dR of B lymphocytes, is a membrane site involved in human cell regulation. To analyze the specificities of the binding sites for EBV and for C3d on the gp 140 molecule, two distinct approaches were used. First, anti-EBV/C3dR mAb were prepared against highly purified EBV/C3dR. Nine anti-EBV/C3dR mAb were obtained. Four of these anti-EBV/C3dR mAb inhibited C3d binding but not EBV binding on gp 140, whereas four others exerted an inverse effect. These differences could not be due to differences in isotype, antibody concentration, affinity constant, and number of molecules bound on cell surface, as these parameters were identical for the nine used mAb. Second, polyclonal anti-idiotypic antibodies (Ab2) were prepared against F(ab)'2 fragments of polyclonal anti-EBV/C3dR (Ab1). Ab2 recognized the variable portion of Ab1 as controlled by immunoblotting experiments. Ab2, which did not react with the cell surface, inhibited Ab1 binding on Raji cells. Ab2 mimicked the EBV/C3dR by its properties to bind to particle-bound C3d and EBV, preventing their binding on Raji cell surface. C3d binding specificities contained in Ab2 were isolated by affinity chromatography on C3b/C3bi-Sepharose. These specificities, being the internal image of C3d binding site of EBV/C3dR, reacted with Ab1 and inhibited particle-bound C3d binding on Raji cells but did not react with EBV. Taken together, these data support strongly that gp 140, the EBV/C3dR, carried two distinct binding sites, one for EBV and one for C3d.
Mapping the Supply Chain Digitalization: An Exploratory Bibliometric Analysis (2023)

In a global business environment facing more and more risks (recession risk, geo-economic risk, natural risks) digitalization can represent a solution for increasing resilience at the level of the supply chain. The development of new technologies has created the premises for the transformation of traditional logistics chains into digital logistics chains and the pandemic crisis accelerated the process for most companies and institutions. The scope of this paper is identifying the interest in researching the subject of supply chain digitalization. The study is based on a quantitative research method, bibliometric analysis. A query was conducted on the Scopus platform database to identify scientific works (research articles, books, papers presented at conferences) that include keywords specific to our topic, in the title, abstract or body. The results of our study confirm a growing scientific interest for researching the topic of supply chain digitization: from 2002 to February 2023, 913 documents addressing this subject or related issues were identified.
Failed Back Surgery Syndrome (1991)

Long, Donlin M. MD, PhD.; North, Richard B. MD.; Kidd, David H. BA; Campbell, James N. MD.Author Information
Treatment Results of Hodgkin's Disease in Indian Children (1995)

This is a retrospective study of Hodgkin's disease in children less than 15 years of age who were registered at Tata Memorial Hospital in India from January 1985 through December 1990. Clinicopathologic characteristics and response were evaluated in 147 patients and survival was calculated in 187. There were 126 boys and 21 girls (6:1). All patients were treated with combination chemotherapy and involved field radiotherapy. The COPP schedule was given to 108 patients. COPP/ABVD to 33, and ABVD to 6. Ninety-three patients (63%) had stage I or II disease and 54 (37%) had stage III or IV disease. B symptoms were observed in 65 patients (56%) and bulky disease in 40 (27%). Histologically, the most common subtype was mixed cellularity, seen in 95 patients (65%). Complete response was observed in 136 (89%), partial response in 6 (4%), and there were 4 treatment-related deaths. Relapse has been observed in 11%. Seven-year actuarial survival was 73% and event-free survival was 64%. Median survival has not yet been reached, with a median follow-up of 36 months.
New results on the reactione+e−→μ+μ−at√s =29GeV (1985)

We have measured the process ${e}^{+}$${e}^{\mathrm{\ensuremath{-}}}$\ensuremath{\rightarrow}${\ensuremath{\mu}}^{+}$${\ensuremath{\mu}}^{\mathrm{\ensuremath{-}}}$ at \ensuremath{\surd}s =29 GeV using the High Resolution Spectrometer at SLAC PEP. The forward-backward charge asymmetry is ${A}_{\ensuremath{\mu}\ensuremath{\mu}}$=-(4.9\ifmmode\pm\else\textpm\fi{}1.5\ifmmode\pm\else\textpm\fi{}0.5)% based on 5057 events. A subsample of 3488 ${\ensuremath{\mu}}^{+}$${\ensuremath{\mu}}^{\mathrm{\ensuremath{-}}}$ events in the angular range \ensuremath{\Vert}cos\ensuremath{\theta}\ensuremath{\Vert}&lt;0.55 gives a cross-section ratio of ${R}_{\ensuremath{\mu}\ensuremath{\mu}}$=0.990\ifmmode\pm\else\textpm\fi{}0.017\ifmmode\pm\else\textpm\fi{}0.030. The resulting couplings of the weak neutral current are ${g}_{a}^{e}$${g}_{a}^{\ensuremath{\mu}}$=0.208\ifmmode\pm\else\textpm\fi{}0.064\ifmmode\pm\else\textpm\fi{} 0.021 and ${g}_{v}^{e}$${g}_{v}^{\ensuremath{\mu}}$=0.027 \ifmmode\pm\else\textpm\fi{}0.051\ifmmode\pm\else\textpm\fi{}0.089. The QED cutoff parameters are ${\ensuremath{\Lambda}}_{+}$&gt;170 GeV and ${\ensuremath{\Lambda}}_{\mathrm{\ensuremath{-}}}$&gt;146 GeV at 95% C.L.