gebhart/patrepeval huggingface dataset:
Chromogranin A and the Autonomic System: Decomposition of Heart Rate Variability and Rescue by Its Catestatin Fragment (2010)

Chromogranin A (CHGA/Chga) has been implicated in the genesis of systemic hypertension and consequent cardiac abnormalities. Catestatin (CST) (human CHGA(352-372)) replacement reduces blood pressure elevation and increases baroreflex sensitivity in Chga knockout (KO) mice. Because of the dampened baroreflex sensitivity, we reasoned that KO mice would display altered heart rate variability (HRV). Thus, we evaluated beat-to-beat measurements in HRV in wild-type (WT) and KO mice, before and after CST replacement. HR dynamics were evaluated by bipolar Einthoven electrocardiogram, with deconvolution into time and frequency domains, as well as Lorenz nonlinear return analyses. At baseline, HR was higher [444 +/- 24 beats per minute (bpm)] in KO compared with WT (330 +/- 18 bpm) mice. The total power in the HRV spectra was substantially diminished in KO animals. CST increased total power but only in KO mice. Each time-domain parameter was substantially lower in KO compared with WT mice, and the CST in the KO group could reverse the differences. Lorenz analysis revealed reductions in S1 (short axis perpendicular to the line of identity in the ellipse) and S2 (long axis along the line of identity in the ellipse) in KO animals, indicating that regulation of HRV is diminished in the parasympathetic and sympathetic domains. CST replacement caused restoration of both S1 and S2, in the KO group. These data suggest that Chga has a profound effect on autonomic tone to the heart and that its CST fragment is responsible for such actions. The results suggest future strategies for intervention in cardiovascular disorders accompanied by adverse HRV profiles.
Regulation of human heart contractility by essential myosin light chain isoforms. (1996)

Most of the patients with congenital heart diseases express the atrial myosin light chain 1 (ALC-1) in the right ventricle. We investigated the functional consequences of ALC-1 expression on the myosin cycling kinetics in the intact sarcomeric structure using multicellular demembranated fibers ("skinned fibers") from the right ventricular infundibulum of patients with Tetralogy of Fallot (TOF), double outlet right ventricle (DORV), and infundibular pulmonary stenosis (IPS), Force-velocity relation was analyzed by the constant-load technique at maximal Ca2+ activation (pCa 4.5). Half-time of tension development (t1/2) was investigated by monitoring contraction initiation upon photolytic release of ATP from caged-ATP in rigor. The patients investigated here expressed between 0 and 27% ALC-1. There was a statistically significant correlation between ALC-l and maximal shortening velocity (Vmax) which rose 1.87-fold from 1.2 muscle length per second (ML/s) to 2.25 ML/s in a normal (0% ALC-1) and diseased (19.9% ALC-1) ventricle. Half-time of tension development decreased 1.85-fold with increasing ALC-1 expression (t1/2) was 0.252 s and 0.136 s at 2 and 18.4% ALC-1, respectively). We conclude that the expression of ALC-1 in the human heart modulates cross-bridge cycling kinetics accelerating shortening velocity and isometric tension production.
Altered Surface Properties of Escherichia coli Associated With a Specific Amino Acid Change in the S12 Ribosomal Protein of Streptomycin-Resistant Mutants (1977)

Escherichia coli mutants resistant to streptomycin exhibited differences in countercurrent distribution from the parental strains. The degree of difference from the parental strain correlated with the degree of restriction of translation and thus the particular strA allele. The changes in countercurrent distribution in the phase systems used probably resulted predominantly from surface charge alterations. The differences in countercurrent distribution in these and other mutants may be a useful selective technique to obtain different types of mutants for which specific selective techniques may not be available. In addition, it appears that the surface properties of cells, which determine their position in countercurrent distribution, are a function of the translational efficiency and fidelity, and that the surface of cells consists of a mosaic that is an expression of this translational fidelity.
Sinonasal Sarcoidosis: Review and Report of Fifteen Cases (2004)

On the basis of this study, we propose the following diagnostic criteria: 1) histopathologic confirmation of noncaseating granuloma; 2) chronic rhinosinusitis poorly responsive to conventional treatment and radiologic evidence of rhinosinusitis, often with nodules on the septum and/or the turbinates; 3) elevated level of angiotensin-converting enzyme; 4) positive gallium scan (if performed); 5) frequent evidence of systemic, especially pulmonary, sarcoidosis; 6) no evidence of other granulomatous diseases, such as Wegener granulomatosis.
Regulation of GLS1 Expression by Scleraxis in Cardiac Fibroblasts (2020)

Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix, including fibrillar collagens, proteoglycans, and fibronectin. This process is energy‐intensive for cardiac fibroblasts, however it remains unclear how these energy metabolic requirements are met. Liver fibrosis, and in particular collagen synthesis, has been shown to be dependent on glutaminolysis, in which glutamine is converted to glutamate by the enzyme glutaminase (GLS) with further conversion to a‐ketoglutarate to fuel oxidative metabolism via the tricarboxylic acid cycle, but a role for glutaminolysis in cardiac fibrosis remains to be demonstrated. We previously showed that scleraxis (Scx) is a transcription factor that is critically required for the conversion of cardiac fibroblasts to myofibroblasts, but its potential role in glutaminolysis in these cells is unknown. We report here that freshly‐isolated rat cardiac fibroblasts (P0 – unpassaged) passaged twice to become myofibroblasts (P2) show concomitant up‐regulation of Scx by 5‐fold and GLS1 by 4‐fold in P2 versus P0. Scx over‐expression induced a 20‐fold increase in GLS1 expression. To determine whether GLS1 expression is dependent on Scx, we examined GLS1 expression in activated mouse cardiac fibroblasts (P1) isolated from wild type or Scx knockout mice. Scx knockout attenuated GLS1 expression by almost 90%. TGFb is a potent inducer of cardiac fibrosis that both dramatically up‐regulates Scx expression, and requires Scx for many of its downstream effects. TGFb treatment of wild type mouse P1 activated fibroblasts doubled the expression of GLS1, but had no effect in Scx KO cells. In silico analysis revealed four putative Scx binding sites in the GLS1 promoter. While TGFb significantly up‐regulated expression of the myofibroblast marker periostin in cardiac fibroblasts, both scleraxis knockout and the glutaminase inhibitor CB‐839 attenuated this induction, indicating a failure to convert to myofibroblasts. These findings suggest that Scx regulates GLS1 expression to facilitate increased energy metabolism during cardiac fibroblast to myofibroblast conversion. Support or Funding Information Canadian Institutes of Health Research (PJT‐162422).
Quantification of cell identity from single-cell gene expression profiles (2015)

The definition of cell identity is a central problem in biology. While single-cell RNA-seq provides a wealth of information regarding cell states, better methods are needed to map their identity, especially during developmental transitions. Here, we use repositories of cell type-specific transcriptomes to quantify identities from single-cell RNA-seq profiles, accurately classifying cells from Arabidopsis root tips and human glioblastoma tumors. We apply our approach to single cells captured from regenerating roots following tip excision. Our technique exposes a previously uncharacterized transient collapse of identity distant from the injury site, demonstrating the biological relevance of a quantitative cell identity index.
Effect of CO2 Treatment on Storage and Shelf Life of Sweet Peppers1 (1977)

Abstract Exposure of sweet peppers ( Capsicum annuum L.) to 30% CO 2 for 6 days at 13°C immediately after harvest retarded wall softening and ripening in air at 13° but caused the subsequent development of severe calyx injury and decay at 20°. Slight to moderate calyx injury was induced by a 6-day exposure to 20% CO 2 . Severity of the injury was greater when the CO 2 was used with 3% O 2 as compared to 21% O 2 . Injury was not induced by a 6-day treatment with 10% CO 2 . When stored at 13°, quality of peppers with this treatment was superior after 10 days, but inferior after 20 days to that of peppers kept continuously in an atmosphere of 5% CO 2 and 3% O 2 . Benefits obtained from the 3-day elevated CO 2 treatment (10 to 30%) were nullified after 10 days’ storage at 13°. Ethylene production was greatly inhibited in high CO 2 atmospheres but rose immediately after transfer to air. Red color development, chlorophyll degradation, and ascorbic acid accumulation were retarded only in the presence of high CO 2 .
Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. (1993)

A series of potent and highly selective time-dependent monocyclic beta-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is described. The intrinsic potency of these compounds, as exemplified by L-680,833 (k(inactivation)/K(i) of 622,000 M-1.s-1), is reflected at the cellular level where it inhibits generation of the specific N-terminal cleavage product A alpha-(1-21) from the A alpha chain of fibrinogen by enzyme released from isolated polymorphonuclear leukocytes stimulated with fMet-Leu-Phe with an IC50 of 0.06 microM. The inhibitory activity of L-680,833 is also apparent in whole blood stimulated with A23187, where it inhibits formation of A alpha-(1-21) and PMNE-alpha 1-proteinase inhibitor complex formation with IC50 values of 9 microM. Pharmacokinetic studies indicate that after oral dosing L-680,833 is bioavailable in rats and rhesus monkeys. This oral bioavailability is reflected by the inhibition (i) of tissue damage elicited in hamster lungs by intratracheal instillation of human PMNE and (ii) enzyme released from human PMN stimulated after their transfer into the pleural cavity of mice. The properties of L-680,833 allow it to effectively supplement the activity of natural inhibitors of PMNE in vivo, suggesting that this type of low-molecular-weight synthetic inhibitor could have therapeutic value in diseases where PMNE damages tissue.
Observation of Dispersion Cancellation and Inversion in the Anomalous and Normal GVD Regimes (2022)

We observe for the first t ime g roup-velocity d ispersion ( GVD) i nversion and cancellation in both the normal and anomalous GVD regimes while using space-time wave packets that are endowed with non-differentiable angular dispersion.
CCDC 232552: Experimental Crystal Structure Determination (2006)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Characterization of peanut lines with interspecific introgressions conferring late leaf spot resistance (2020)

Abstract Late leaf spot (LLS) disease caused by Nothopassalora personata (Berk. &amp; M.A. Curtis) U. Braun, C. Nakash, Videira &amp; Crous is prevalent among pathogens encountered in peanut ( Arachis hypogaea L.) growing regions. Chemical control is expensive, sometimes inaccessible, and can be difficult to apply. One effective solution to control this disease is the deployment of resistant cultivars. IAC 322 is a breeding line resistant to foliar fungal disease and harbors alien introgressions from A. cardenasii Krapov. &amp; W.C. Gregory, a wild diploid relative of peanut. The objective of this study was to determine the level of LLS resistance conferred by introgressed segments in families derived from TifNV‐High O/L × IAC 322. Phenotyping for LLS resistance was performed under both in vitro and field conditions, which provided sufficient disease pressure to separate the means of susceptible and resistant checks, although there was no statistically significant separation of LLS resistance among the families with introgressions. However, consistent levels of LLS resistance observed in the family with A02‐top/A03‐bottom segments makes it a valuable resource for peanut breeding. In addition, late‐season field disease ratings were found to correlate with the entire LLS infection progression under both field and in vitro conditions. Among the parameters collected for in vitro experiments, numbers of LLS lesions and sporulating LLS lesions at late stages of LLS infection and incubation period can be used to predict LLS resistance under field conditions.
Global Strong Solutions to Some Nonlinear Dirac Equations in Super-Critical Space (2013)

We study the initial value problem of some nonlinear Dirac equations which are<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:msup><mml:mrow><mml:mi>L</mml:mi></mml:mrow><mml:mrow><mml:mi>m</mml:mi></mml:mrow></mml:msup><mml:mfenced separators="|"><mml:mrow><mml:mi>ℝ</mml:mi></mml:mrow></mml:mfenced></mml:math>critical. Corresponding to the structure of nonlinear terms, global strong solutions can be obtained in different Lebesgue spaces by using solution representation formula. The uniqueness of weak solutions is proved for the solution<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>U</mml:mi><mml:mo>∈</mml:mo><mml:msup><mml:mrow><mml:mi>L</mml:mi></mml:mrow><mml:mrow><mml:mi>∞</mml:mi></mml:mrow></mml:msup><mml:mfenced separators="|"><mml:mrow><mml:mfenced open="[" close="]" separators="|"><mml:mrow><mml:mn>0</mml:mn><mml:mo>,</mml:mo><mml:mi>T</mml:mi></mml:mrow></mml:mfenced><mml:mo>;</mml:mo><mml:mi> </mml:mi><mml:msup><mml:mrow><mml:mi>Y</mml:mi></mml:mrow><mml:mrow><mml:mi>m</mml:mi><mml:mo>+</mml:mo><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mfenced separators="|"><mml:mrow><mml:mi>ℝ</mml:mi></mml:mrow></mml:mfenced></mml:mrow></mml:mfenced></mml:math>.
Novel Deception Techniques for Malware Detection on Industrial Control Systems (2021)

To maintain the availability of industrial control systems (ICS), it is important to robustly detect malware infection that spreads within the ICS network. In ICS, a host often communicates with the determined hosts; for instance, a supervisory control host observes and controls the same devices routinely via the network. Therefore, a communication request to the unused internet protocol (IP) address space, i.e., darknet, in the ICS network is likely to be caused by malware in the compromised host in the network. That is, darknet monitoring may enable us to detect malware that tries to spread indiscriminately within the network. On the other hand, clever malware, such as malware determining target hosts of infection with reference to host lists in the networks, infects the confined hosts in the networks, and consequently evades detection by security sensors or honeypots. In this paper, we propose novel deception techniques that lure such malware to our sensor, by embedding the sensor information continuously in the lists of hosts in the ICS networks. In addition, the feasibility of the proposed deception techniques is shown through our simplified implementation by using actual malware samples: WannaCry and Conficker.
Generalized Concatenated Types of Codes for Erasure Correction (2014)

Generalized Concatenated (GC), also known as Integrated Interleaved (II) Codes, are studied from an erasure correction point of view making them useful for Redundant Arrays of Independent Disks (RAID) types of architectures combining global and local properties. The fundamental erasure-correcting properties of the codes are proven and efficient encoding and decoding algorithms are provided. Although less powerful than the recently developed PMDS codes, this implementation has the advantage of allowing generalization to any range of parameters while the size of the field is much smaller than the one required for PMDS codes.
An analytical approach for estimating optimal multi-layer network cost, exploiting the flexible-grid optical technology (2013)

In this paper we provide analytical insights for dimensioning a multi-layer network and in particular the virtual optical transport network topology exported to the packet client layer according to cost and power consumption. A new approach is described, approximating optimum routing, that can be effectively used to provide an estimation of network cost and reference architectures in network implementations. Results using this estimation approach are compared with those obtained using other estimation approaches regarding bandwidth allocation and network costs. We found that the approximated routing calculations, applied on a virtual network topology, do not significantly penalize the accuracy of the results. This approach can be extended to analyze the impact of new a optical networking technique, flexible-grid wavelength division multiplexing (WDM), providing some insights regarding scenarios in which migration from fixed-grid WDM systems to flexible-grid WDM systems would be advantageous in terms of capital cost and power consumption.
Voltage-dependent potentiation of the activity of cardiac L-type calcium channel alpha 1 subunits due to phosphorylation by cAMP-dependent protein kinase. (1993)

Barium currents mediated by the alpha 1 subunit of the cardiac L-type Ca channel expressed in Chinese hamster ovary (CHO) cells were increased up to 10-fold during dialysis of the cell with the catalytic subunit of cAMP-dependent protein kinase. After partial activation by exogenous kinase, the activity of the alpha 1 subunit was also reversibly potentiated up to 3.5-fold by prepulses to voltages in the range of 0 to +150 mV. Potentiation at +48 mV developed with a biphasic time course with time constants of 131 ms and 8 s. Reversal at -60 mV was biphasic with half-times of 12 ms and 100 ms and was blocked in the presence of the phosphatase inhibitor okadaic acid. Both the increase in calcium-channel activity during dialysis with kinase and the voltage-dependent potentiation were accompanied by shifts in the voltage dependence of activation to more negative membrane potentials. The increases in Ba current due to protein phosphorylation and to the dihydropyridine Ca channel agonist Bay K8644 were approximately additive. The results show that the alpha 1 subunit of the cardiac L-type Ca channel is sufficient for substantial modulation of Ca-channel activity by cAMP-dependent protein kinase and for potentiation by state-dependent protein phosphorylation. Voltage-dependent potentiation of the activity of the alpha 1 subunit may contribute to the increase in contractile force in response to increased rate of stimulation, the positive staircase effect in heart muscle.
A 110 dB CMRR/PSRR/gain CMOS Operational Amplifier (2005)

A CMOS operational amplifier with 110 dB CMRR/PSRR/gain is described. High CMRR is achieved using a cascoded input stage with high output impedance tail current source. A lateral PNP transistor and low-threshold voltage MOS transistor are used to create the voltage source stabilizing the drain-source voltage of the input transistors. The common-mode input signal range includes the negative rail voltage. A high stability self-regulated bias PTAT core is used to improve PSRR. The amplifier comprises two gain stages connected via a cascoded current mirror with voltage gain boost. The output class AB stage uses local feedback control of the reference voltages, and has an improved quiescent current vs. supply voltage stability.
Removal of formaldehyde at low concentration using various activated carbon fibers (2007)

Abstract Adsorption of low concentration formaldehyde on pitch‐based, rayon‐based, and PAN‐based activated carbon fibers (ACFs) and an unactivated PAN‐based carbon fiber (PAN‐CF) was investigated by a dynamic method. The pore structure and surface chemistry of these samples were characterized by liquid nitrogen adsorption, elemental analysis, and X‐ray photoelectron spectroscopy. Results revealed that the pore structure, especially surface chemical composition, greatly influence the formaldehyde adsorption. PAN‐based ACFs showed the highest formaldehyde adsorption capacity because there are more abundant nitrogen‐containing groups, especially pyrrolic, pyridonic, pyridinic, and quaternary on the surface. The breakthrough time and formaldehyde adsorption capacity of one kind of PAN‐ACF were 361 min and 0.478 mmol/g, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
DESARROLLO DE LA INTELIGENCIA EMOCIONAL EN EL EMPRENDIMIENTO EDUCATIVO EN LOS ESTUDIANTES DE BACHILLERATO GENERAL DE LA UNIDAD EDUCATIVA "LIBERTAD” (2022)

La presente investigación tiene como objetivo establecer la influencia del desarrollo de habilidades de inteligencia emocional en el emprendimiento educativo de los estudiantes de la Unidad Educativa Libertad. La metodología tiene un enfoque cuantitativo, utilizando los métodos: científico, deductivo y analítico, con la participación de 86 estudiantes y 10 docentes, el instrumento utilizado fue la encuesta en formato online, mediante Google forms. Los resultados obtenidos, determinaron la carencia en el desarrollo de habilidades de inteligencia emocional con respecto al emprendimiento formativo como habilidad que contribuye al crecimiento personal y educativo del alumnado. Se precisa que los estudiantes son conscientes que el adecuado manejo de sus emociones, constituye una competencia esencial en el ámbito personal como profesional.
Modular Arrangement and Secretion of a Multidomain Serine Protease (2002)

The Limulus Factor C (FC), a multidomain glycoprotein that binds bacterial endotoxin with high affinity, belongs to the serine protease family of the complement and blood coagulation cascade. Here, we provide compelling evidence for the importance of modular arrangement and relevance of the proline-rich region (PRR) and N-glycosylation to the secretion and function of FC. We propose that PRR could be a universal conformational domain that regulates protein folding and targeting. FCs lacking PRR preceding the serine protease domain, were localized intracellularly. Misfolded conformers of the intracellular FCs were more susceptible to trypsin digestion. Glycosylation inhibition studies indicate that the presence but not the exact structure of the N-glycans affects the secretion of FC, although the complexity of glycosylation may influence its endotoxin-induced proteolytic cleavage with resultant enzymatic activity. Disruption of specific N-glycan sites at positions 740, 767, and 912, downstream of the PRR, at or near the serine protease domain, blocks its secretion. Co-expressed molecular chaperones like canine calnexin associates with glycosylated FCs to increase its solubility and secretion level but did not alter their expression profiles. Our results clearly demonstrate that the folding and secretion of a multidomain serine protease like FC are determined by its modular domain arrangement and site-specific N-glycans. The secreted FCs containing the N-terminal portion of FC are able to detect lipopolysaccharide with high sensitivity. We also identified the lectin-like and sushi 4 domains to contribute to the binding of lipopolysaccharide.