gebhart/patrepeval huggingface dataset:
Abstract 3245: IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity of murine breast and colon carcinomas (2016)

Abstract Interleukin (IL)-15-N72D superagonist-complexed with IL-15RαSushi-Fc fusion protein (IL-15SA/IL-15RαSu-Fc; ALT-803) has been reported to exhibit significant anti-tumor activity in murine myeloma, rat bladder cancer, and murine glioblastoma models. In this study, we examined the immunomodulatory and anti-tumor effects of IL-15SA/IL-15RαSu-Fc in tumor-free and highly metastatic tumor-bearing mice. Here, IL-15SA/IL-15RαSu-Fc significantly expanded NK and CD8+ T cells. In examining natural killer (NK) cell subsets, the greatest significant increase was in highly cytotoxic and migrating (CD11b+, CD27hi; high effector) NK cells, leading to enhanced function on a per-cell basis. CD8+ T cell subset analysis determined that IL-15SA/IL-15RαSu-Fc significantly increased IL-15 responding memory (CD122+, CD44+) CD8+ T cells, in particular those having the innate (NKG2D+, PD1-) phenotype. In 4T1 breast tumor-bearing mice, IL-15SA/IL-15RαSu-Fc induced significant anti-tumor activity against spontaneous pulmonary metastases, depending on CD8+ T and NK cells, and resulting in prolonged survival. Similar anti-tumor activity was seen in the experimental pulmonary metastasis model of CT26 colon carcinoma cells, particularly when IL-15SA/IL-15RαSu-Fc was combined with a cocktail of checkpoint inhibitors, anti-CTLA-4 and anti-PD-L1. Altogether, these studies showed for the first time that IL-15SA/IL-15RαSu-Fc (1) promoted the development of high effector NK cells, (2) enhanced function of NK cells, and (3) played a vital role in reducing tumor metastasis and ultimately survival, especially in combination with checkpoint inhibitors. Citation Format: Peter S. Kim, Anna R. Kwilas, Wenxin Xu, Sarah Alter, Emily K. Jeng, Hing C. Wong, Jeffrey Schlom, James W. Hodge. IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity of murine breast and colon carcinomas. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3245.
Role of the Receptor in the Mechanism of Action of Adenosine 3′:5′-Cyclic Monophosphate (1971)

Highly purified cAMP-dependent protein phosphokinase from adrenal-cortical tissue contains cAMP-receptor activity. In activating the kinase, cAMP binds to the receptor and causes it to dissociate from its complex with the kinase. The kinase, freed of receptor, is fully activated and no longer stimulable by cAMP. Kinase can be similarly activated by differentially denaturing the receptor with heat. Addition of receptor suppresses kinase activity; this suppression can be overcome by cAMP. After dissociation of receptor, two molecular forms of the activated kinase exist. The cAMP receptor thus functions as a repressor of the protein kinase; binding of cAMP to receptor causes it to dissociate from the kinase, which is then fully activated.
Evaluation of Sleeve Gun Effectiveness in Repelling Adult Striped Bass (1990)

This reports documents tests of the effectiveness of low frequency sounds produced by a sleeve gun in redistributing adult striped bass (Morone saxatilis) in net pens in the forebay of John H. Kerr Dam, Virginia. Behavioral observations and statistical analyses indicated that adult striped bass in 20- by 4- by 4-ft (6.1- by 1.2- by 1.2-m) pens exhibited only subtle and inconsequential responses to sounds produced by a 150-cm3 sleeve gun. Startle responses were apparent only early in the tests, and fright responses, that would have been suggested by increased swimming speeds or strong directional movements away from the sound source, were never observed.
Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells (2000)

Mammalian secreted phospholipases A(2) (sPLA2s) comprise a group of at least eight enzymes, including the recently identified group X sPLA2. A bacterial expression system was developed to produce human group X sPLA2 (hGX). Inhibition studies show that the sPLA2 inhibitor LY311727 binds modestly more tightly to human group IIA sPLA2 than to hGX and that a pyrazole-based inhibitor of group IIA sPLA2 is much less active against hGX. The phospholipid head group preference of vesicle-bound hGX was determined. hGX binds tightly to phosphatidylcholine vesicles, which is thought to be required to act efficiently on cells. Tryptophan 67 hGX makes a significant contribution to interfacial binding to zwitterionic vesicles. As little as 10 ng/ml hGX releases arachidonic acid for cyclooxygenase-2- dependent prostaglandin E(2) generation when added exogenously to adherent mammalian cells. In contrast, human group IIA, rat group V, and mouse group IB sPLA2s are virtually inactive at releasing arachidonate when added exogenously to adherent cells. Dislodging cells from the growth surface enhances the ability of all the sPLA2s to release fatty acids. Studies with CHO-K1 cell mutants show that binding of sPLA2s to glycosaminoglycans is not the basis for poor plasma membrane hydrolysis by group IB, IIA, and V sPLA2s.
Insulin-like growth factor I treatment reduces clinical deficits and lesion severity in acute demyelinating experimental autoimmune encephalomyelitis (1995)

Our goal was to test the effects of insulin-like growth factor I (IGF-I) treatment on clinical deficits, lesion number and lesion size in acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with an emulsion containing guinea pig spinal cord. In this EAE model, there is severe immune-mediated demyelination, which resembles that seen in actively demyelinating MS lesions. On day 12-13 after EAE induction, a total of 23 pairs of rats with the same mild degree of tail and hind limb weakness were given either intravenous IGF-I or placebo twice daily for 8 days. The daily IGF-I dose used in the first trial was 200 micrograms (about 0.6 mg kg-1) and in the second and third trials was 1 mg (about 3.0 mg kg-1). IGF-I treatment reduced permeability of the blood-spinal cord barrier to Evans blue-albumin. Maximum clinical deficit scores of IGF-I-treated rats were significantly lower and treated rats recovered faster than controls. IGF-I treatment produced significant reductions in weight loss and hind limb weakness. Treatment also improved treadmill walking, stride length and climbing performance. Morphometric analysis showed that spinal cord inflammatory lesions were significantly smaller and fewer in IGF-I-treated rats. The higher IGF-I dose produced a greater reduction in clinical and pathological deficits. We conclude that IGF-I treatment promotes clinical recovery by reducing EAE-induced blood-spinal cord barrier changes and the associated immune-mediated inflammatory lesions. Our results suggest that IGF-I may be useful in treating patients with multiple sclerosis and other demyelinating diseases.
Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults (2017)

Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired. Experimental gait data was processed using musculoskeletal modeling to calculate the contact forces, impulses and pressure distribution in the tibiofemoral joint. Correlates to local cartilage thickness and mean T1ρ and T2 relaxation times of the weight-bearing area of the femoral condyles were examined. Local thickness was significantly correlated with local pressure: medial thickness was correlated with medial condyle contact pressure and contact force, and lateral condyle thickness was correlated with lateral condyle contact pressure and contact force during stance. Furthermore, average T1ρ and T2 relaxation time correlated significantly with the peak contact forces and impulses. Increased T1ρ relaxation time correlated with increased shear loading, decreased T1ρ and T2 relaxation time correlated with increased compressive forces and pressures. Thicker cartilage was correlated with higher condylar loading during walking, suggesting that cartilage thickness is increased in those areas experiencing higher loading during a cyclic activity such as gait. Furthermore, the proteoglycan and collagen concentration and orientation derived from T1ρ and T2 relaxation measures were related to loading.
Effects of plant bioregulators on nutrients, insect resistance and yield of corn (Zea mays L.] (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of plant bioregulators on nutrients, insect resistance and yield of corn (Zea mays L.]Paul A. Hedin, W. Paul Williams, Frank M. Davis, and Alonzo C. ThompsonCite this: J. Agric. Food Chem. 1988, 36, 4, 746–748Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/jf00082a017https://doi.org/10.1021/jf00082a017research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prognostic significance of VEGF‐C, semaphorin 3F, and neuropilin‐2 expression in oral squamous cell carcinomas and their relationship with lymphangiogenesis (2014)

Results indicate SEMA3F is an inhibitor of tumor progression and provide evidence for an association between NRP2 and VEGF-C, lymphangiogenesis, lymph node metastasis. This suggests the prognostic significance and potential therapeutic value of the VEGF-C/SEMA3F/NRP2 axis for OSCCs.
Bis(η 5 ‐Pentamethylcyclopentadienyl) Complexes of Scandium (2014)

Use of pentamethylcyclopentadienyl ligands (C5Me5) in place of cyclopentadienyl (Cp) provides reactive, but thermally robust monomelic 14-electron scandocene derivatives. A useful starting material for the synthesis of a variety of derivatives of permethylscandocene is the chloride complex. All experiments discussed in this chapter are conducted under argon in a glove box or a high-vacuum line. The chapter describes the procedures for the preparation and properties of bis(η5-pentamethylcyclopentadienyl) chloroscandium, bis(η5-pentamethylcyclopentadienyl) methylscandium, bis(η5-pentamethylcyclopentadienyl) phenylscandium, and bis(η5-pentamethylcyclopentadienyl)(o-tolyl) scandium.
Complex electrochemical processing of the metallic wastes from a rhenium-containing nickel superalloy in sulfuric acid electrolytes (2011)

A principal technological scheme for the complex electrochemical processing of the wastes from a rhenium-containing nickel superalloy in sulfuric acid electrolytes is developed on the basis of physicochemical studies. The process according to the technological scheme produces potassium perrhenate, calcium tungstate, nickel sulfate, and a tantalum concentrate as marketable products.
Preparation of LiClO4-doped Titanium Organodiphosphonates Possessing Oligomeric Ethylene Oxide Chains and Their Ionic Conductivity (2013)

Abstract Hybrids possessing both oligomeric ethylene oxide chains and Ti–O–P networks were prepared from TiCl4 and organodiphosphonic acid [(HO)2OP(C2H4O)3C2H4PO(OH)2] via a nonhydrolytic sol–gel process and subsequently treated with a LiClO4 solution. The P/Ti ratio was fixed at 2 and the ethylene oxide unit/Li+ ratio was changed from 5 to 20. Li+ ions are likely to be solvated by ether oxygen atoms. Li+ ion transport in the hybrids with ionic conductivity values in the 10−5 S cm−1 range was observed at ambient temperatures.
A Meta-Learning Scheme for Adaptive Short-Term Network Traffic Prediction (2020)

Network traffic prediction is a fundamental prerequisite for dynamic resource provisioning in wireline and wireless networks, but is known to be challenging due to non-stationarity and due to its burstiness and self-similar nature. The prediction of network traffic at the user level is particularly challenging, because the traffic characteristics emerge from a complex interaction of user level and application protocol behavior. In this work we address the problem of predicting the network traffic at the user level over a short horizon, motivated by its applications in cellular scheduling. Motivated by recent works on robust adversarial learning, we treat the prediction problem for non-stationary traffic in an adversarial context, and propose a meta-learning scheme that consists of a set of predictors, each optimized to predict a particular kind of traffic, and of a master policy that is trained for choosing the best fit predictor dynamically based on recent prediction performance, using deep reinforcement learning. We evaluate the proposed meta-learning scheme on a variety of traffic traces consisting of video and non-video traffic. Our results show that it consistently outperforms state-of-the-art predictors, and can adapt to before unseen traffic without the need for retraining the individual predictors.
Phase synchronization of inverter linking power system network with distributed generation under voltage sag (2013)

This paper investigates a phase synchronization of an inverter between distributed generation and power system network. The phase synchronization is focused based on equivalent inertia of the inverter to synchronous generator. It is experimentally clarified that the phase synchronization of the inverter maintains stable linkage with the power system network at an abrupt voltage sag.
Reliability and contact resistance of polysilicon beam leads for use in a high-density connector (2002)

A study was conducted to measure and characterize the reliability of polysilicon cantilever beams with electroplated gold pads for use in a high-density connector. Beam leads of various lengths and widths with electroplated gold contact pads on their ends were tested over 1000 cycles to determine their mechanical reliability, and to measure their contact resistance with gold bumps on a separate substrate. The optimum length and width of polysilicon beams, insulated on top and bottom with CVD oxide and nitrides, were determined to be 400 /spl mu/m and 125 /spl mu/m, respectively. The contact resistance was measured to be about 1.22/spl plusmn/0.68 /spl Omega/ after 1000 cycles. These results indicate very high-density connectors with high mechanical reliability and low contact resistance can be fabricated.
Organoboranes as alkylating agents (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboranes as alkylating agentsGeorge W. Kabalka , John D. Baker Jr., and Gary W. Neal Cite this: J. Chem. Educ. 1976, 53, 9, 549Publication Date (Print):September 1, 1976Publication History Received3 August 2009Published online1 September 1976Published inissue 1 September 1976https://doi.org/10.1021/ed053p549RIGHTS & PERMISSIONSArticle Views125Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
A demonstrator of all-optronic multifunctional down-looking synthetic aperture LADAR (2015)

The design and laboratory experiment of a demonstrator of all-optronic down-looking synthetic aperture imaging ladar (SAL) is presented in this paper, in which the sensing-to-processing chain is carried out with light. The ultra-fast processing capability from image acquisition to real-time reconstruction is shown. The demonstrator consists of a down-looking SAL unit with a beam scanner and an optical processor. The down-looking SAL unit has a transmitter of two coaxial orthogonally polarized beams and a receiver of polarization-interference self-heterodyne balanced detection. The linear phase modulation and the quadratic phase history are produced by the projection of movable cylindrical lenses. Three functions of strip-map mode, spotlight mode and static mode are available. The optical processor is an astigmatic optical system, which reduces to a Fourier transform system and a free-space of the Fresnel diffraction to realize the matched filtering. A spatial light modulator is used as the input interface. The experiment is performed with an optical collimator. The system design is given, too. The down-looking SAL has the features such as a big coverage with an enhanced receiving aperture and little influence from atmospheric turbulence and the optical processor is simple.
Daily wind power profiles determination using clustering algorithms (2012)

Wind power will become a major contributor to electricity supply in many countries around the world over the next decades. Therefore, the wind farms owners must be equipped with tools that allow assisting them in managing and planning the wind power generation. With this work it is intended to extract from a database of wind power generation useful knowledge to support the wind farm owners in the management of their wind farms and also to improve their behaviour in the electricity market. To achieve the proposed goal, it was implemented a framework architecture based on the knowledge discovery process, involving several steps, specifically the pre-processing data phase, the application of the several clustering algorithms and finally the evaluation of the algorithms performance based on several clusters validity indices. In order to validate the proposed survey, a case study with a real database from a Portuguese wind farm is used.
Two-color fluorescent in situ hybridization in the embryonic zebrafish brain using differential detection systems (2011)

Since POD activity is rather quickly quenched by substrate excess, less abundant transcripts can often not be efficiently visualized even when applying TSA. The use of AP-Fast Blue fluorescent detection may provide a helpful alternative for fluorescent transcript visualization, as the AP reaction can proceed for extended times with a high signal-to-noise ratio. Our protocol thus provides a novel alternative for comparison of two different gene expression patterns in the embryonic zebrafish brain at a cellular level. The principles of our method were developed for use in zebrafish but may be easily included in whole-mount FISH protocols of other model organisms.
HIV-1 protease inhibitors. (1997)

The PIs have emerged as critical drugs for people with HIV infection. Optimal use involves combination with reverse transcriptase inhibitors. Resistance develops to each agent, and cross-resistance is likely. These agents must be used at full doses with attention to ensuring patient compliance. The expense of these agents may be offset by forestalling disease progression and death and returning people to productive life. Selecting the initial PI must be individualized, and factors to consider include proven activity, possible toxicities, dosing regimens, drug interactions, and costs.
Drug Delivery: On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications (Adv. Funct. Mater. 10/2015) (2015)

On page 1488, B. Herranz-Blanco, H. A. Santos, and co-workers fabricate a multistage drug delivery nanocomposite, comprising porous silicon nanoparticles and micellar pH-responsive polymers, by microfluidic nanoprecipitation. The drug-loaded multistage platform shows high cytocompatibility, pH-dependent cell growth inhibition capacity, and reduced internalization by phagocytic macrophage cells. This nanocomposite is a good candidate for further development as a platform for cancer drug delivery.
ChemInform Abstract: REACTIONS OF 1‐CHLORO‐2‐PHENYL‐1‐CYCLOPROPENES (1977)

Abstract Da sich die bei 20‐25°C instabilen Cyclopropene (I) auch in CCl 4 ‐Lösungen nach wenigen Tagen zersetzen, ist es von Interesse, ihre Reaktivität zu untersuchen.
Precise Quantification of Next Generation Sequencing Ion Torrent™ and Illumina Libraries using the QuantStudio™ 3D Digital PCR Platform (2014)

Current methods for quantifying NGS libraries do not provide precise measurements of functionally relevant molecules. Accurate absolute quantification of NGS libraries is critical for obtaining optimal throughput from each sequencing run using the Ion Torrent PGM™ and Proton™ platforms and the Illumina HiSeq and MiSeq® platforms. Thus a need exists to precisely measure library concentration prior to clonal amplification for these sequencing systems. The QuantStudio™ 3D Digital PCR System (QS3D) offers a highly precise method for quantifying libraries prior to sequencing. Compared to alternative methods, Life Technologies chip-based dPCR approach is particularly attractive to accurately quantify libraries due to a simple workflow and eliminating the need for standard curves as required by traditional qPCR methods. TaqMan® gene expression assays were specifically designed that span the P1 and A adapters for Ion Torrent™ libraries, and that span the P5 and P7 adapters for Illumina libraries. A reaction mix was formulated by mixing diluted library with the QS3D Master Mix and TaqMan® assay and then loaded onto a QS3D chip. This chip was then sealed and the mixture amplified on a thermal cycler. Lastly, the data was visualized using the QuantStudio™ 3D AnalysisSuite Cloud Software which displays the target concentration. The concentration obtained from the digital platform was correlated to the percent of template beads (pre-enriched) for the Ion Torrent™ libraries and showed a tight range between 10–14% as determined by flow cytometry. The digital data obtained from the Illumina libraries showed a tight correlation with cluster density on an Illumina platform. We therefore present a simple and accurate workflow for quantifying NGS libraries using the QuantStudio™ 3D Digital PCR Platform.