gebhart/patrepeval huggingface dataset:
Does Arctic warming reduce preservation of organic matter in Barents Sea sediments? (2020)

Over the last few decades, the Barents Sea experienced substantial warming, an expansion of relatively warm Atlantic water and a reduction in sea ice cover. This environmental change forces the entire Barents Sea ecosystem to adapt and restructure and therefore changes in pelagic–benthic coupling, organic matter sedimentation and long-term carbon sequestration are expected. Here we combine new and existing organic and inorganic geochemical surface sediment data from the western Barents Sea and show a clear link between the modern ecosystem structure, sea ice cover and the organic carbon and CaCO 3 contents in Barents Sea surface sediments. Furthermore, we discuss the sources of total and reactive iron phases and evaluate the spatial distribution of organic carbon bound to reactive iron. Consistent with a recent global estimate we find that on average 21.0 ± 8.3 per cent of the total organic carbon is associated to reactive iron (fOC-Fe R ) in Barents Sea surface sediments. The spatial distribution of fOC-Fe R , however, seems to be unrelated to sea ice cover, Atlantic water inflow or proximity to land. Future Arctic warming might, therefore, neither increase nor decrease the burial rates of iron-associated organic carbon. However, our results also imply that ongoing sea ice reduction and the associated alteration of vertical carbon fluxes might cause accompanied shifts in the Barents Sea surface sedimentary organic carbon content, which might result in overall reduced carbon sequestration in the future. This article is part of the theme issue ‘The changing Arctic Ocean: consequences for biological communities, biogeochemical processes and ecosystem functioning’.
Development of Economic Impact Models for RTU Economizer Faults (2014)

Stuck outdoor-air dampers can lead to significant energy waste when undiagnosed for extended periods of time. This is especially true for packaged (rooftop) air conditioners where preventative maintenance may not be frequent or only reserved for emergencies. Automated fault detection and diagnosis (AFDD) tools for outdoor-air dampers and economizers have been proposed in the past to reduce the effort and cost for this kind of maintenance and are even required by some new building standards (CA - Title 24 2013). While qualitatively, the effects of stuck damper faults are understood, much less has been written about these faults’ impacts on cooling cycle performance and actual operating costs. An investigation of incorrect outdoor-air fraction on cooling capacity, efficiency, sensible heat ratio (SHR), and run-time is presented. An evaluation of the commanded damper position based on economizer controller logic is used to capture impacts of stuck damper faults at the full range of position and under different ambient conditions. Using experimental data, these models are validated for a 4-ton rooftop air-conditioner (RTU) with integrated economizer. The combined effect of these impacts are analyzed based on air-side virtual sensors outputs and modified version of an economic performance degradation index (EPDI) first proposed by Li and Braun (2006). This performance index estimates fault impacts on operation costs as well as the added equipment costs due to the need to operate the air-conditioner longer. These economic performance impact outputs can be used in an optimal maintenance scheduling tool in future work.
The rumen: a feed-deconstructing reactor fueling milk production and superintending its composition (2012)

International audience
Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity (1995)

Apolipoprotein (apo) B48 is synthesized by mammalian small intestine as a result of post-transcriptional RNA editing. This process is mediated by an enzyme complex containing a catalytic subunit, apobec-1, which is homologous to other cytidine deaminases, particularly in a domain (H/C)-(A/V)-E-(X)24-30-P-C-(X)2-C which coordinates zinc, apobec-1, expressed as a glutathione S-transferase fusion protein, demonstrates both apoB RNA editing and cytidine deaminase activity. His61, Cys93, and Cys96, the putative zinc-coordinating residues, were mutated to Arg, Ser, and Ser, respectively, with loss of RNA editing activity and either great reduction or abolition of cytidine deaminase activity. Mutation of the catalytically active Glu63 residue to Gln and Pro92 to Leu abolished both cytidine deaminase and RNA editing activity. The conservative His61-->Cys mutation, which should coordinate zinc, retained both editing and cytidine deaminase activity. Thus, zinc binding is required for both apoB RNA editing and cytidine deaminase activity. Mutation of the first four leucines within the heptad repeat of the leucine-rich region (LRR) of apobec-1 resulted in reduced RNA editing but preservation of wild-type cytidine deaminase activity. GST/APOBEC-1 was also demonstrated to cross-link to apoB RNA. Mutation of His61-->Arg abolished RNA binding, while the Glu63-->Gln and Cys96-->Ser mutant proteins showed wild-type levels of RNA binding. The remaining mutants had reduced levels of activity. Overexpression of wild-type apobec-1 in McA 7777 cells resulted in a 5-6-fold increase in editing of endogenous apoB. Transfection of the His61-->Cys, LRR, and Cys93-->Ser mutants increased endogenous editing 2-3-fold, while Glu63-->Gln and His61-->Arg mutants acted as dominant negatives, reducing endogenous editing. These data suggest that apobec-1 has distinct functional domains which modulate activity in the context of the apoB mRNA editing enzyme.
Effects of Potassium Concentration on Firing Patterns of Low‐Calcium Epileptiform Activity in Anesthetized Rat Hippocampus: Inducing of Persistent Spike Activity (2006)

These results suggest that persistent status epilepticus-like spike activity can be induced by nonsynaptic mechanisms when synaptic transmission is blocked. The unique double-spike pattern of this activity is presumably caused by higher K+ concentration augmenting the frequency of typical low-calcium nonsynaptic burst activity.
Correction for Sakwinska et al., “Nasopharyngeal Microbiota in Healthy Children and Pneumonia Patients” (2019)

Volume 52, no. 5, p. 1590–1594, 2014, [https://doi.org/10.1128/JCM.03280-13][1]. Page 1591: The following paragraph should appear at the end of the Materials and Methods section.

Nucleotide sequence accession number. Raw 454 sequencing data have been deposited in the NCBI Short Read Archive under
Floating Capacitor Active Charge Balancing for PHEV Applications (2010)

Li-ion battery chemistry provides high energy density, which is extremely important for plug-in hybrid vehicles (PHEV). However, Li-ion batteries are also more prone to damage by overcharging and over-discharging. For PHEV applications, a battery pack consists of many battery cells in series and parallel configurations. Over time, the state of charge (SOC) of individual cells can deviate from one another because of various conditions and manufacturing variability, increasing the likelihood of over- charging and/or over-discharging individual cells. This project explores the use of a floating capacitor active charge balancing (ACB) system for a Li-ion battery pack. A prototype floating capacitor ACB system is built and implemented in a custom built pack consisting three parallel strings with four cells in each string (3P4S). The battery pack is exercised on a cycler to deviate the SOCs of the cells, and the ACB system is used for no-load balancing. Results verify previous simulations of the same system. The floating capacitor ACB system sufficiently balances the pack with no load balancing. In addition, the system is made of simple components, decreasing complexity and provides good economic efficiency.
A Comparison of DC and Pulsed Fe‐Ni Alloy Deposits (1993)

The effect of hydrodynamics and temperature on the electrodeposition of Fe‐Ni alloys has been investigated with dc, pulse, and pulse‐reverse electrodeposition techniques. Strong mass‐transfer effects in the co‐deposition of Fe on rotating cylindrical cathodes were indicated at high current densities. Many features of the present deposition process are shown to be consistent with the Hessami and Tobias model. A comparison of the polarization behavior of single‐metal and alloy deposition clearly demonstrate the lower rate of Ni co‐deposition in accord with previous reports of anomalous co‐deposition of Fe‐Ni alloys. X‐ray diffraction studies indicate that the crystalline phases (fcc, bcc, and mixed fcc + bcc) in the electrodeposited alloys depend on alloy composition and deposition conditions. Thermal expansion coefficients of electroformed cylinders of near‐Invar compositions ranged from for unannealed alloys to for alloys annealed at 680°C. Average internal stress of deposits increased with increasing Fe content.
Wavelet localization of the Radon transform (1994)

The authors develop an algorithm which significantly reduces radiation exposure in X-ray tomography, when a local region of the body is to be imaged. The algorithm uses the properties of wavelets to essentially localize the Radon transform. This algorithm differs from previous algorithms for doing local tomography because it recovers an approximation to the original image, not the image module the nullspace of the local tomography operator, or the Lambda transform of the image. This is possible because the authors do not truly invert the interior Radon transform, but rather sample the Radon transform sparsely away from the local region of interest. Much attention in the field has been directed towards localized tomography. The authors believe that this technique represents a significant contribution towards this effort.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Photorearrangement of 2-cyanobicyclo[2.2.1]hept-2-ene. Observation of 1,2- and 1,3-sigmatropic shifts (1982)

Irradiation of 2-cyanobicyclo[2.2.1]hept-2-ene (2-cyanonorbornene, 4) in hexane, with the full arc of a mercury vapour lamp, gives the rearrangement products 1-cyanobicyclo[4.1.0]hept-2-ene 5 and 7-cyanotricyclo[4.1.0.0 3.7 ]heptane 6 in the ratio 20:1. These products were separated by preparative vpc. The structure of the major product 5 was determined by single crystal X-ray analysis. Reduction of 5 with lithium aluminum hydride gave the corresponding primary amine, which was converted to the p-bromobenzenesulfonamide 9, mp 150–151 °C, which gave single crystals from ethanol–water. The crystal and molecular structures are described. The minor product 6 was hydrogenated to give 7-cyanobicyclo[2.2. 1]heptane. Formation of 5 and 6 may involve concerted σ 2s + π 2s and σ 2a + π 2a processes respectively, which are photochemically allowed.
PP.17.20 (2015)

Objective: Blood pressure variability is regarded as an independent marker of cardiovascular risk. Aerobic and isometric exercises are thought to reduce blood pressure mainly by reducing sympathetic activity, which affects blood pressure variability. In the current randomized controlled trial we assess the effect of different exercise modalities on blood pressure variability Design and method: 64 hypertensive patients were prospectively randomized in three groups to undergo the following training modalities for 12 weeks: A. handgrip isometric training 5 times weekly consisting of 2 contractions of 2 min at 30% of maximal power with each arm corresponding to an overall duration of 12 min per training session; B. placebo-handgrip training 5 times weekly consisting of 2 contractions of 2 min at 5% of maximal power with each arm corresponding to an overall duration of 12 min per training session and C. aerobic exercise training of 30 minutes at least 3 times per week (no structured exercise regimen). The coefficient of variation (CV) of systolic and diastolic blood pressure in the 24-ABP measurement was used as statistical measure of blood pressure variability. Results: Only patients in the aerobic exercise group showed a significant reduction of the 24 h ABPM systolic (p = 0.02) and of the daytime systolic blood pressure (p = 0.009) compared to patients undergoing handgrip or placebo-handgrip training. Aerobic training led to a borderline significant improvement of the systolic (p = 0.048) and diastolic blood pressure variability (0.047). Isometric training had no effect on blood pressure variability.Conclusions: Aerobic but not isometric training leads to a significant reduction of the ambulatory systolic blood pressure and to improvement of the daytime blood pressure variability.
A real-time parametric stiffness observer for VSA devices (2011)

We consider the problem of estimating non-linear time-varying stiffness of a mechanical system based only on force and position measurements. A recent work presented a non-parametric stiffness observer, which converges to within an Uniformly Ultimately Bounded neighborhood of the real stiffness value. The method provides excellent results for applications where the system is persistently excited. In this paper, we provide a parametric identification method that complements the previous solution in that it can provide, after a sufficiently long learning period, a complete model of the nonlinear stiffness, which can be applied henceforth even in the absence of excitation. Convergence conditions for the proposed method are discussed. Simulation and experimental results are provided, illustrating the performance of the proposed algorithm.
BIOFILTRATION CONTROLS ODORS FROM ASPHALT PROCESSING PLANT (1999)

The exact etiology of xerosis is not entirely understood and likely depends on several genetic and environmental mechanisms. Aging-associated changes in epidermal function include a marked reduction in total lipids in the stratum corneum relative to young skin due to reduced epidermal lipid synthesis. In aging skin, xerosis is significantly associated with pruritus. Studies have shown that lipid-containing skin care, such as a gentle ceramide-containing cleanser and moisturizer, promotes a healthy barrier reducing xerosis and pruritus in individuals with mature skin.&nbsp; Conclusions: The development of xerosis in mature skin involves several genetic and environmental mechanisms. Skincare, including gentle cleansers and moisturizers, has reduced xerosis and pruritus in mature skin individuals.&nbsp; &nbsp;&nbsp; J Drugs Dermatol. 2024;23(1):1253-1259.&nbsp; &nbsp;&nbsp; doi:10.36849/JDD.7560.
ChemInform Abstract: A New Family of Inhibitors of Mycobacterium tuberculosis Thymidine Monophosphate Kinase. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Detection of convergence areas in digital breast tomosynthesis using a contrario modeling (2009)

We propose a new method to detect architectural distortions and spiculated masses in digital breast tomosynthesis volumes. To achieve this goal, an a contrario approach is used. In this approach, an event, corresponding to a minimal number of structures converging toward the same location, is defined such that its expectation of occurrence within a random image is very low. Occurrences of this event in real images are then detected and considered as possible lesion locations. During the last step, the number of false positives is reduced through classification using attributes computed on histograms of structure orientations. The approach was tested using the leave-one-out method on a database composed of 38 breasts (10 containing a lesion and 28 containing no lesion). A sensitivity of 0.8 at 1.68 false positives/breast was achieved.
Games as Technological Entry Point: A Case Study of Uzbekistan (2003)

This paper considers cross-cultural patterns of game-playing activities.The paper is part of an overall argument regarding computer games as a possible technological entry point for novice users.In particular, increasing use of games in educational settings has drawn attention to the fact that computer games can be a way for young people to gain an initial exposure to computer technology.The paper discusses game-playing patterns in the US and South Korea in order to demonstrate that such patterns vary based on country.The paper then considers survey work conducted in March 2003 in Uzbekistan that presents a snapshot of game-playing activity in a country that is in early stages of computer technology adoption.This paper is part of a larger study that seeks to argue that game-playing, if fostered correctly, can serve as an effective point of entry to computer technology for youth in developing countries and in areas where computer penetration is relatively low.
A high-performance scalable submicron MOSFET for mixed analog/digital applications (2002)

A scalable submicron MOSFET with excellent analog characteristics has been designed and fabricated for integration as a 'third' transistor with conventional CMOS processes. Excellent analog device characteristics have been obtained, including a factor of 10 improvement in available gain, a factor of 100 reduction in peak substrate current, and significantly reduced hot-electron degradation. An angled implantation technique is utilized to allow easy incorporation into submicron processes with negligible impact on the conventional devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An Adaptive Quantization Using Iir Filter Bank For Speech Compression (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
Supplementary Figure 6 from Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors (2023)

&lt;p&gt;PDF file - 1066KB, MEK inhibition alone and combination PI3K + MEK inhibition decreases serotonin secretion, while BEZ235 decreases CgA expression. (A) BON and (B) QGP-1 cells were plated in 24 well plates at a density of 1x105 cells/cm2. After 24h, cells were washed and maintained with serum-free medium. Cells were subsequently treated with either (upper panels) control, BKM120 (5 �M), PD0325901 (100 nM), or combination BKM120 + PD0325901 (5 �M/100 nM), or (lower panels) control, BEZ235 (1000 nM), PD0325901 (100 nM), or combination BEZ235 + PD0325901 (1000 nM/100 nM) for 1h. Media was collected and serotonin measured by serotonin ELISA (* p &lt; 0.05 vs. control). (C) Whole cell lysates were collected following 24h of drug treatment with either control, BKM120 (5 �M), PD0325901 (100 nM), or combination BKM120 + PD0325901 (5 �M/100 nM), or control, BEZ235 (1000 nM), PD0325901 (100 nM), or combination BEZ235 + PD0325901 (1000 nM/100 nM) and analyzed for CgA expression. β-actin was used as a loading control.&lt;/p&gt;
XRF 100316D/SN 2010bh: CLUE TO THE DIVERSE ORIGIN OF NEARBY SUPERNOVA-ASSOCIATED GAMMA-RAY BURSTS (2010)

X-ray Flash (XRF) 100316D, a nearby super-long under-luminous burst with a peak energy E_p \sim 20 keV, was detected by Swift and was found to be associated with an energetic supernova SN 2010bh. Both the spectral and the temporal behavior of this burst are rather similar to that of XRF 060218, except that the latter was associated with a "less energetic" SN 2006aj and had a prominent soft thermal emission component in the spectrum. We analyze the spectral and temporal properties of this burst, and interpret the prompt gamma-ray emission and the early X-ray plateau emission as synchrotron emission from a dissipating Poynting-flux-dominated outflow, probably powered by a magnetar with a spin period of $P \sim 10$ ms and the polar cap magnetic field $B_{\rm p} \sim 3\times 10^{15}$ G. The energetic supernova SN 2010bh associated with this burst is, however, difficult to interpret within the slow magnetar model, which implies that the nascent magnetar may spin much faster with an initial rotation period $\sim 1$ ms, and thus suggests a delay between the core collapse and the emergence of the relativistic magnetar wind from the star. The diverse behaviors of low-luminosity GRBs and their associated SNe may be understood within a unified picture that invokes different initial powers of the central engine and different delay times between the core collapse and the emergence of the relativistic jet from the star.
Supplementary Figures from SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti–PD-1–Resistant Model of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Figures&lt;/p&gt;
Watching Vibrational Energy Transfer in Liquids with Atomic Spatial Resolution (2002)

Ultrafast spectroscopy was used to study vibrational energy transfer between vibrational reporter groups on different parts of a molecule in a liquid. When OH stretching vibrations of different alcohols were excited by mid-infrared laser pulses, vibrational energy was observed to move through intervening CH2 or CH groups, taking steps up and down in energy, ending up at terminal CH3 groups. For each additional CH2 group in the path between OH and CH3, the time for vibrational energy transfer increased by about 0.4 picosecond.
Image reconstruction using non-adjacent drive configurations (electric impedance tomography) (1994)

The standard 'back projection' image reconstruction algorithm developed at Sheffield uses data obtained by passing current between adjacent pairs of electrodes and measuring voltage differences between the remaining pairs. Previously it has been argued that this configuration gives the best resolution compared to all other bipolar drive configurations. However, it also gives the worst signal to noise ratio data and it is possible that under conditions of poor signal to noise ratio it may be advantageous to use an alternative drive configuration, even at the expense of resolution. A general image reconstruction algorithm for any bipolar drive configuration has been produced. Reconstruction algorithms for the adjacent, cross (drive electrodes 90 degrees apart) and polar drive (drive electrodes 180 degrees apart) have been examined and compared in terms of their resolution and noise performance.