gebhart/patrepeval huggingface dataset:
Short-term outcomes after elective minimally invasive colectomy for diverticulitis (2010)

Abstract Background The role of minimally invasive surgery in complicated diverticulitis is still being elucidated. The aim of this study was to compare short-term outcomes in patients undergoing minimally invasive surgery for complicated or uncomplicated diverticular disease. Methods All patients who had elective minimally invasive surgery for diverticulitis between 2003 and 2008 were identified from a prospectively maintained database. Complicated disease was defined as diverticulitis associated with abscess, fistula, stricture or bleeding. Univariable analysis was performed to compare safety and short-term outcomes in patients with complicated and uncomplicated diverticulitis. Results A total of 361 patients (136 with complicated and 225 with uncomplicated diverticulitis) were operated on with either a laparoscopic (36·0 per cent) or a hand-assisted laparoscopic (64·0 per cent) surgical technique. There were no significant differences between the groups with respect to age, sex, body mass index, laparoscopic approach, postoperative recovery protocol or previous open surgery. Conversion rates were similar for complicated and uncomplicated disease (14·0 versus 11·6 per cent respectively; P = 0·514). There was no difference between the groups with respect to return of bowel function (mean 3·1 versus 3·2 days respectively; P = 0·156), morbidity (27·9 versus 19·6 per cent; P = 0·070) or mean length of stay (5·4 versus 4·8 days; P = 0·186). There were no deaths within 30 days. Conclusion Elective minimally invasive colectomy is feasible for patients with uncomplicated and complicated diverticulitis, with equivalent outcomes.
5'-Amido analogs of adenosine 3',5'-cyclic monophosphate (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5'-Amido analogs of adenosine 3',5'-cyclic monophosphateBernd Jastorff, Akira Murayama, Friedrich Cramer, and Hans HettlerCite this: J. Org. Chem. 1971, 36, 20, 3029–3033Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://doi.org/10.1021/jo00819a027RIGHTS & PERMISSIONSArticle Views179Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (562 KB) Get e-Alerts Get e-Alerts
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia (2012)

To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average onset age 14.12 ± 2.49 months) in a primary immunodeficiency disease center between 2004 and 2011. In 30 patients, detectable anti-neutrophil auto-antibodies were HNA1a in 16 patients, HNA1c in 15, MHC Class I in 14, HNA1b in eight, MHC Class II in five, and HNA2a in three. Their average neutropenia duration was 27.04 ± 2.08 months. Of eight patients without detectable auto-antibodies, three had ELANE mutations [Ser126Pro, Arg170Phe and Cys223stop] and recurrent muco-cutaneous infections and sepsis. The patient with nonsense ELANE mutation [Cys223stop] had the lowest NE activity (16.8). Thus, patients with ELANE mutations have undetectable antibodies and more severe and younger-onset muco-cutaneous infections, prolonged healing and decreased serum NE activity that require prompt intervention.
The relationship between thaumatin, a sweet protein and thaumatopain, a cysteine protease, from the arils of Thaumatococcus daniellii. (1991)

Conference Article| August 01 1991 The relationship between thaumatin, a sweet protein and thaumatopain, a cysteine protease, from the arils of Thaumatococcus daniellii. ANDREW G. STEPHEN; ANDREW G. STEPHEN 1Proteolysis Research Group, Department of Biochemistry, University of Liverpool, PO Box 147, LIVERPOOL, L69 3BX Search for other works by this author on: This Site PubMed Google Scholar ROY POWLS; ROY POWLS 1Proteolysis Research Group, Department of Biochemistry, University of Liverpool, PO Box 147, LIVERPOOL, L69 3BX Search for other works by this author on: This Site PubMed Google Scholar ROBERT J. BEYNON ROBERT J. BEYNON 1Proteolysis Research Group, Department of Biochemistry, University of Liverpool, PO Box 147, LIVERPOOL, L69 3BX Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (3): 297S. https://doi.org/10.1042/bst019297s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation ANDREW G. STEPHEN, ROY POWLS, ROBERT J. BEYNON; The relationship between thaumatin, a sweet protein and thaumatopain, a cysteine protease, from the arils of Thaumatococcus daniellii.. Biochem Soc Trans 1 August 1991; 19 (3): 297S. doi: https://doi.org/10.1042/bst019297s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Improved bearing and range estimation via high-order subspace based Unitary ESPRIT (2002)

Two new algorithms for the passive localization of near-field sources with a uniform linear array (ULA) are presented and compared in this paper. They exploit multiple invariances among certain fourth-order cross-cumulant matrices of non-zero and zero lags, respectively. Both algorithms utilize 2-D Unitary ESPRIT to obtain automatically paired bearing and range estimates. The resulting closed-form subspace-based methods incorporate forward-backward averaging, use efficient real-valued processing of the cumulant data, and outperform previously proposed high-order subspace-based algorithms for the localization of near-field sources. In the limit, the presented schemes also work for far-field sources.
Lipoprotein(a), Ethnicity, and Cardiovascular Risk (2011)

F or 20 years, textbooks of medicine and guidelines for cardiovascular risk screening have suggested that elevated levels of lipoprotein(a) [Lp(a)] are a risk marker for coronary heart disease in white populations, but not among blacks. This observation, included in the Adult Treatment Panel III guidelines in 2002, 1 has long been puzzling, because blacks have both higher Lp(a) levels and higher absolute cardiovascular event rates than age-and sex-matched whites. Many explanations for this assumed ethnicity-based Lp(a) paradox have been described in the cardiovascular literature, including effect modification on the basis of diverse environmental and social influences, as well as genetic differences related to variation in kringle IV type 2 copy number. In retrospect, however, this embedded piece of preventive cardiology wisdom may prove to be a faux clinical pearl that entered the literature because of little more than poor statistical power.
Effective WIP dependent lot release policies: A discrete event simulation approach (2011)

In this paper we explore a lot release policy for wafer fabs that is based on the WIP threshold of the bottleneck station. Our results show that this policy is effective in cycle time improvement while keeping the same level of throughput compared with a case where no policy is applied. The application of this policy is practical and needs less considerations compared to policies that aim at keeping the WIP constant throughout the fab.
Regulation of syringomycin synthesis in Pseudomonas syringae pv. syringae and defined conditions for its production (1985)

Production of the phytotoxin, syringomycin (SR), by Pseudomonas syringae pv. syringae strain B301D was regulated by both iron and inorganic phosphate similar to that of many bacterial secondary metabolites. Iron concentrations of 2 mumol/l or more in deferrated potato-dextrose broth (PDB) resulted in the production of 1024 SR units/ml, a yield comparable to that produced in non-deferrated PDB. Moreover, production of one SR unit required approximately 0.4 ng of available FeCl3. No SR was produced by strain B301D in deferrated PDB despite growth nearly identical with that of B301D in deferrated PDB supplemented with 10 mumol/l FeCl3. Furthermore, a phosphate concentration of 1 mmol/l or more was suppressive to SR production. Of the amino acids tested, L-histidine at a concentration of ca 20 mmol/l was the most effective nitrogen source for SR synthesis under defined conditions. Based on these observations, a synthetic medium, SR minimal, was formulated for SR or syringotoxin production by representative strains of Ps. syringae pv. syringae. The regulation of phytotoxin production is discussed in relation to pathogen survival and virulence.
In vivo evaluation of poorly crystalline hydroxyapatite-based biphasic calcium phosphate bone substitutes for treating dental bony defects (2010)

Poorly crystalline hydroxyapatite was improved so that it has better cell affinity in vitro. We studied the efficacy of a novel resorbable poorly crystalline hydroxyapatite-based biphasic calcium phosphate, BonaGraft, for bone regeneration in vivo. The beagle was used as an animal model, and cylindrical artificial bone defects (3 mm in diameter and 6 mm long) were produced in the alveolar bone. The BonaGraft (ratio of poorly crystalline hydroxyapatite to b-tricalcium phosphate, 60:40) was used to fill in the defect, and unfilled defects served as a control group. At 5, 8 and 10 weeks after the operation, the size of the residual graft and new bone formation were evaluation by a histomorphometric analysis. In a clinical trial, 33 enrolled patients included 15 males and 18 females with ages ranging from 35 to 54 years. The main indications were ridge augmentation (n = 12), sinus lifting (n = 2), repair of periodontal disease (n= 14), and repair of radicular cysts (n= 5). The clinical outcomes of the surgery were primarily evaluated by clinical radiographs. In the animal study, implanting BonaGraft produced greater new-bone formation (74.5% ± 1.0%) at 10 weeks postoperatively than that of the control (40.2% ± 0.3%). BonaGraft particles were gradually resorbed and substituted by bone. The in vivo graft resorption time and bone healing time of 12.1 weeks were mathematically determined by the least squares method. In the clinical test, all patients implanted with BonaGraft reported satisfactory clinical outcomes without major material-related side effects. According to the radiographic pictures, implantation of BonaGraft enhanced bone formation. According to the animal study results, BonaGraft has a suitable resorption period and satisfactory outcomes of new bone formation. The clinical study produced high satisfaction with clinical results both objectively and subjectively. For this reason, BonaGraft seems to be an alternative choice for a bone substitute in dental applications.
Efficient distributed routing algorithms for a synchronous circuit-switched hypercube (1992)

The authors discuss the development and performance of a series of distributed routing algorithms for a synchronous circuit-switched hypercube and enhanced hypercube. Several centralized routing algorithms were developed. All the routing algorithms developed were derived from a single high-level concept of how routing can be accomplished in a circuit-switched hypercube. The routing algorithms were derived from the corresponding packet switching routing algorithm. The routing algorithms have different strengths and weaknesses when compared with one another, and these are considered. It is shown that the highest performing algorithm has an extremely low probability of blocking for the enhanced hypercube and the standard hypercube.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The management of neurosurgical patients with postoperative bacterial or aseptic meningitis or external ventricular drain-associated ventriculitis (2000)

(2000). The management of neurosurgical patients with postoperative bacterial or aseptic meningitis or external ventricular drain-associated ventriculitis. British Journal of Neurosurgery: Vol. 14, No. 1, pp. 7-12.
Adsorption of Copper(II) on NH2-MCM-41 and Its Application for Epoxidation of Styrene (2011)

Amine functionalized MCM-41 (NH2-MCM-41) with varying amine amount (6.4, 10.2, 12.8, and 20 wt %) was prepared by the cocondensation method using cetyltrimethylammonium bromide (CTAB) as structure-directing agent (SDA), 3-aminopropyltriethoxysilane (APTES), and tetraethylorthosilicate (TEOS). The characterizations of the synthesized samples were performed by X-ray diffraction, scanning electron microscopy, UV–vis diffuse reflectance spectroscopy, and Fourier transform infrared spectral studies. The results revealed that the ordered hexagonal structure of MCM-41 was well retained after the amine functionalization irrespective of the amount of amine loading. Adsorption of Cu(II) from the aqueous state with varying parameters such as concentration, temperature, and pH was performed over as-synthesized and surfactant-removed NH2-MCM-41. Atomic adsorption spectroscopy investigations reported a higher percentage of adsorption in the case of as-synthesized NH2-MCM-41 compared to surfactant-removed samples. The experimental data fitted well to Langmuir and Freundlich adsorption isotherms. The sample (12.8)NH2-MCM-41 showed the highest copper adsorption at pH 5.5, Cu(II) concentration of 59.6 ppm, and temperature 323 K. The sample (12.8)NH2-MCM-41–Cu(59.6) was used as a catalyst for epoxidation of styrene using hydrogen peroxide as the oxidant. GC analyses reported a significant conversion of 17.2% with 64% selectivity toward formation of styrene epoxide.
Electrophilic warheads in covalent drug discovery: an overview (2022)

In spite of the numerous electrophilic warheads, only a fraction of them is used in current drug discovery projects. Recent studies identified new tractable residues by applying a wider array of warhead chemistries. However, versatile, selective warheads are not available for all targetable amino acids, hence discovery of new warheads for these residues is needed. Broadening the toolbox of the warheads could result in novel inhibitors even for challenging targets developing with significant therapeutic potential.
Photoelectric, nonlinear optical, and photorefractive properties of composites based on poly(N-vinylcarbazole) and gallium phthalocyaninate (2011)

Poly(N-vinylcarbazole) layers containing tetra-5-crown-5-gallium phthalocyaninate (R4Pc)Ga(OH) are shown to possess photoelectric and photorefractive sensitivity at a wavelength of 1064 nm. This effect is associated with the formation of supramolecular ensembles of (R4Pc)Ga(OH) molecules with electronic optical absorption in the near-IR range and nonlinear optical properties. For the composite containing 5 wt % (R4Pc)Ga(OH) supramolecular ensembles, the dependence of the quantum efficiency of mobile-charge photogeneration on electric field E 0 is well fit by the Onsager equation expanded to E 0 3 at a quantum yield of electron-hole pairs of φ0 = 0.9 s with an initial separation radius of r 0 = 9.8 Å susceptibility χ(3) equal to 1.85 × 10−10 esu is measured via the well-known method of electric-field-induced second-harmonic generation. Two-beam-coupling gain coefficient Γ is found to be 80 cm−1 at E 0 = 120 V/μm.
Dual conductor surface modified SOFC cathode particles and methods of making same (2023)

A novel method to produce ALD films disposed on powders is disclosed. Examples include the formation of a cobalt doped zirconia (CDZ), hafnia, and cobalt doped hafnia (CDH) films on lanthanum strontium cobalt iron oxide (LSCF) powder for solid oxide fuel cell cathodes. The coated powders are sintered into porous cathodes that have utility for preventing the migration of cations in the powder to the surface of the sintered cathode and/or other performance enhancing attributes.
DNA‐Based Barcodes, Nanoparticles, and Nanostructures for the Ultrasensitive Detection and Quantification of Proteins (2004)

Beyond the shadow of a doubt: Detecting antigens, antibodies, pathogens, tumor markers, and potential therapeutics on the femto- to attomolar concentration level is still challenging. Nanostructured materials and the innovative combination of immunoassays with (real-time) PCR and magnetic separation techniques hold promise for the field of ultrasensitive protein analytics.
Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury (2003)

Positive pressure mechanical ventilation has significant systemic effects, but the systemic effects associated with ventilator-induced lung injury (VILI) are unexplored. We hypothesized that VILI would cause systemic microvascular leak that is dependent on nitric oxide synthase (NOS) expression. Rats were ventilated with room air at 85 breaths/minute for 2 hours with either VT 7 or 20 ml/kg. Kidney microvascular leak, which was assessed by measuring 24-hour urine protein and Evans blue dye, was used as a marker of systemic microvascular leak. A significant microvascular leak occurred in both lung and kidney with large VT (20 ml/kg) ventilation. Injection of 0.9% NaCl corrected the hypotension and the decreased cardiac output related to large VT, but it did not attenuate microvascular leak of lung and kidney. Serum vascular endothelial growth factor was significantly elevated in large VT groups. Endothelial NOS expression significantly increased in the lung and kidney tissue with large VT ventilation but not inducible NOS. The NOS inhibitor, N-nitro-L-arginine methyl ester, attenuated the microvascular leak of lung and kidney and the proteinuria with large VT ventilation. Endothelial NOS may mediate the systemic microvascular leak of the present model of VILI.
Laparoscopic cholecystectomy in situs ambiguous with gallbladder stones with biliary pancreatitis: Report of a case (2021)

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Enhanced VLSI Manufacturability Using an Integrated CAD Framework (1994)

Continued improvements in VLSI performance, circuit density and production costs are possible, in part, do to significant advances in lithography. As feature sizes get smaller, design houses are faced with either improving the resolution of their optical lithography lines, or step-up to the cost of newer x-ray based machines. The work at Rice University proposes to integrate design and process-specific CAD tools to provide further use of optical lithography equipment, while reducing feature sizes to improve manufacturability. By integrating photolithography simulators to layout editors, and by providing expert information on the simulated optical and physical resolution of the feature to the designer, compact and smaller circuits can be designated, which are governed by local design rules. This work is complemented by the development of a novel phase shifting technique at Rice based on interferometry which allows for the manufacture of features with high contrast and reduced feature size.
Parallel electromagnetic modeling of 3D microstrip discontinuities using FEM and PML (2000)

An approach is developed for 3D microstrip discontinuities using the finite element method (FEM) and the perfectly matched layers (PML). It is shown that iterative solvers are not suitable for this problem since the matrix equations from the PML-used FEM modeling are rather ill-conditioned and lead to a very slow or nonconvergent result. A newly developed package SuperLU of the sparse LU decomposition solver is incorporated into our developed approach running on a PC-based parallel platform. Various implementation techniques are detailed. Numerical experiments clearly show that the developed approach is reliable, efficient, and suitable for modeling 3D microstrip discontinuities. © 2001 John Wiley & Sons, Inc. Int J RF and Microwave CAE 11: 38–47, 2001
Revisiting the Complexity of Hardware Cache Coherence and Some Implications (2014)

Cache coherence is an integral part of shared-memory systems but is also widely considered to be one of the most complex parts of such systems. Much prior work has addressed this complexity and the verification techniques to prove the correctness of hardware coherence. Given the new multicore era with increasing number of cores, there is a renewed debate about whether the complexity of hardware coherence has been tamed or whether it should be abandoned in favor of software coherence. This article revisits the complexity of hardware cache coherence by verifying a publicly available, state-of-the-art implementation of the widely used MESI protocol, using the Murφ model checking tool. To our surprise, we found six bugs in this protocol, most of which were hard to analyze and took several days to fix. To compare the complexity, we also verified the recently proposed DeNovo protocol, which exploits disciplined software programming models. We found three relatively easy to fix bugs in this less mature protocol. After fixing these bugs, our verification experiments showed that, compared to DeNovo, MESI had 15X more reachable states leading to a 20X increase in verification (model checking) time. Although we were eventually successful in verifying the protocols, the tool required making several simplifying assumptions (e.g., two cores, one address). Our results have several implications: (1) they indicate that hardware coherence protocols remain complex; (2) they reinforce the need for protocol designers to embrace formal verification tools to demonstrate correctness of new protocols and extensions; (3) they reinforce the need for formal verification tools that are both scalable and usable by non-expert; and (4) they show that a system based on hardware-software co-design can offer a simpler approach for cache coherence, thus reducing the overall verification effort and allowing verification of more detailed models and protocol extensions that are otherwise limited by computing resources.