gebhart/patrepeval huggingface dataset:
GRIM-19, a Cell Death Regulatory Gene Product, Is a Subunit of Bovine Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) (2001)

The sequences of 42 subunits of NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria have been described previously. Seven are encoded by mitochondrial DNA, whereas the remaining 35 are nuclear gene products imported into the organelle from the cytoplasm. An additional protein, which does not correspond to any previously known subunit of the complex I assembly, has now been detected. Denaturing gels of subcomplex Ilambda, the hydrophilic arm of complex I, clearly show a hitherto unidentified band, which was digested with trypsin and subjected to mass-spectrometric analysis to provide several peptide sequences, used in cDNA cloning and sequencing. Measurement of the intact protein mass indicated that the N terminus is acetylated. The new complex I subunit (B16.6) is the bovine homolog of GRIM-19, the product of a cell death regulatory gene induced by interferon-beta and retinoic acid, thus providing a new link between the mitochondrion and its electron-transport chain and apoptotic cell death.
Improving tenderness of normal and callipyge lambs with calcium chloride. (1997)

Effects of CaCl2 injection on meat quality traits of 10 normal and 10 callipyge phenotype crossbred lambs were studied. Primal cuts from one side of each carcass served as the control and cuts from the other side were injected. After storage for 14 d at 2 degrees C, chops were evaluated by Warner-Bratzler shear (WBS) force, trained sensory panel, and consumer sensory panel. Treatment of the muscles with 200 mM CaCl2 increased (P < .05) tenderness and lamb flavor intensity scores by the trained sensory panel and decreased (P < .05) WBS force in both normal and callipyge phenotypes. When callipyge muscles were not injected, consumers rated 94% of leg chops, 60% of loin chops, and 89.4% of shoulder chops acceptable in tenderness. However, when callipyge muscles were CaCl2-injected, consumers rated 96.5% of leg chops, 85.4% of loin chips, and 93.5% of shoulder chops acceptable in tenderness. Normal phenotype carcasses had more marbling (P < .05) in a firmer, finer-textured, brighter cherry red longissimus muscle. Injection of CaCl2 did not affect visual lean color or L, a or b values during retail display of the chops. However, CaCl2 injection decreased color uniformity, increased discoloration, and increased browning at d 2. Therefore, a 5% (wt/wt) injection of 200 mM CaCl2 solution can be applied to improve normal and callipyge lamb tenderness and reduce tenderness and juiciness variation without detrimental effects on other palatability traits when evaluated by trained sensory panelists or consumers.
Effect of temperature and clay addition on the thermal behavior of phosphate sludge (2020)

The aim of the present work is to characterize the phosphate sludge from the area of Youssoufia (rich in CaO ∼ 31%) and to study its thermal behavior alone and when mixed with clay from Safi (Morocco). This may contribute to its valorization as an alternative raw material for ceramic industries. The evolution of phases during the thermal treatment of phosphate sludge, clay and sludge–clay mixtures at different mass ratios (25 wt%, 50 wt%, and 75 wt%) was performed at different levels of temperatures from 600 to 1120 °C. Mineralogical analysis by X-ray diffraction (XRD) showed that the sludge mainly consisted of quartz, calcite, dolomite, and francolite. Dolomite and calcite vanished after sludge heating and two new phases were formed, namely akermanite and monticellite. For clay, it mainly consisted of illite, kaolinite, quartz, calcite, and dolomite. After clay sintering at high temperature, a new phase was formed, i.e. anorthite. The effects of the MO/SiO2 ratio (MO = CaO + MgO) in mixtures (clay + sludge) on the crystallization behavior of diopside and fluorapatite, and the disappearance of the akermanite were investigated. The results showed that the crystallization of diopside–fluorapatite increased when the MO/SiO2 ratio increased. El objetivo del presente trabajo es caracterizar un lodo de fosfato del área de Youssoufia (rico en CaO ∼ 31%) y estudiar su comportamiento térmico tras su mezcla con una arcilla de Safi (Marruecos). Este estudio puede contribuir a su valorización como materia prima alternativa para la industria cerámica. La evolución de las fases minerales durante el tratamiento térmico de lodos de fosfato, arcilla y mezclas de lodos y arcilla en diferentes proporciones de masa (25, 50 y 75% de peso) se realizó a diferentes temperaturas, desde 600 a 1.120 °C. El análisis por difracción de rayos X (DRX) permitió conocer la composición mineralógica del lodo formado principalmente por cuarzo, calcita, dolomita y francolita. La dolomita y la calcita desaparecieron tras el calentamiento del lodo y se formaron 2 nuevas fases, a saber, akermanita y monticellita. En cuanto a la arcilla, el análisis mineralógico evideció la presencia de illita, caolinita, cuarzo, calcita y dolomita como fases mayoritarias. Tras la descomposicón de la arcilla se formó anortita como fase de alta temperatura. Se investigaron los efectos de la relación MO/SiO2 (MO = CaO + MgO) en mezclas (arcilla + lodo) sobre la cristalización de diópsido y fluorapatita y la desaparición de la akermanita. Los resultados mostraron que la cristalización de diopsido-fluorapatita aumentó cuando creció el cociente MO/SiO2.
Relationship between sympathetic activity and blood pressure in OSA patients (2013)

Obstructive sleep apnea syndrome (OSAS) is associated with high Sympathetic Activity (SA) and a subsequent risk of hypertension and atherosclerosis. Objectives of this study were to assess the relationship between SA, Blood Pressure (BP) and early cardiovascular disease markers in OSA We studied 38 OSA patients and 17 aged-matched controls. OSA patients were otherwise healthy, without evidence of clinic hypertension. SA was measured by direct peroneal microneurography: Muscle Sympathetic Nerve Activity (MSNA) and all subjects underwent a full polysomnography, 24h Ambulatory Blood Pressure Monitoring (ABPM), arterial stiffness by Pulse Wave Velocity (PWV), vascular reactivity by Peripheral Arterial Tone (PAT) and arterial carotid Intima Media Thickness (IMT). Groups were comparable for all but not for BMI (25.92 ± 2.71 vs 24.20 ± 2.39 kg/m², p= 0.02). Office Systolic and diastolic BP were the same in patients and controls, while on ABPM 24h-diastolic BP was higher in OSAS group (79.92 ± 8.73 vs 74.59 ± 8.83, p=0.046). There was a strong correlation between SA and all BP parameters: systolic and diastolic office BP (R=0.39 and 0.42,p&lt;0.01) and systolic and diastolic 24-ABPM (R=0.38 and 0.46, p&lt;0.001). Burst/min were correlated with PWV and IMT (R=0.52; p=0.036). Preliminary data on 15 OSA and 9 controls were obtained after 6 month and show that CPAP treatment reduced: SA (Bursts/min 40.49 ± 10.63 vs 35.47 ± 10.06, p&lt;0.05), Diurnal DBP (86.86±11.97 vs 82.07±11.12, P=0.03) and nocturnal dipping (-17.14±5.33 vs -11.07±3.54, P=0.002) In “Healthy” OSAS SA is likely to play a role in the pathogenesis of hypertension and atherosclerosis. SA reduction induced by CPAP, may reduce the risk of cardiovascular diseases.
Simplified generic on-line PWM technique for single phase grid connected current source inverters (2012)

Mandatory restrictions for a current source inverter's (CSI's) proper operation, like continuity of the DC link current, complicate the corresponding PWM generation especially in the case of single phase systems. Classical modulation techniques for single phase CSIs suffer from either complexity or unsymmetrical gate signals distribution for the inverter switches. In this paper, a PWM generation technique suitable for single phase CSI's is presented. The proposed technique ensures CSI's adequate operation with the advantages of: (i) Simple generic on-line implementation, (ii) Better utilization of the carrier frequency and (iii) Symmetrical distribution of the inverter's gate signals that ensures equal loss sharing, conduction and switching, among the inverter power semiconductors. System results, using simulations in addition to experimental setup, are utilized to validate the effectiveness of the proposed technique.
Boosting Multi-Task Weak Learners with Applications to Textual and Social Data (2010)

Learning multiple related tasks from data simultaneously can improve predictive performance relative to learning these tasks independently. In this paper we propose a novel multi-task learning algorithm called MT-Adaboost: it extends Ada boost algorithm to the multi-task setting; it uses as multi-task weak classifier a multi-task decision stump. This allows to learn different dependencies between tasks for different regions of the learning space. Thus, we relax the conventional hypothesis that tasks behave similarly in the whole learning space. Moreover, MT-Adaboost can learn multiple tasks without imposing the constraint of sharing the same label set and/or examples between tasks. A theoretical analysis is derived from the analysis of the original Adaboost. Experiments for multiple tasks over large scale textual data sets with social context (Enron and Tobacco) give rise to very promising results.
Lactococcus lactis M4, a potential host for the expression of heterologous proteins (2011)

Based on the 16S rRNA gene molecular analysis, eight Gram-positive cocci milk isolates were identified as L. lactis subsp. lactis. One of the strains, L. lactis M4 was able to maintain transformed low molecular weight plasmid vectors and expressed the GFP gene. This strain has the potential to be developed into a new lactococcal host for the expression of heterologous proteins.
Structure–activity relationships of peptidomimetics that inhibit PPI of HER2‐HER3 (2013)

Human epidermal growth factor receptor-2 (HER2) is a tyrosine kinase family protein receptor that is known to undergo heterodimerization with other members of the family of epidermal growth factor receptors (EGFR) for cell signaling. Overexpression of HER2 and deregulation of signaling has implications in breast, ovarian, and lung cancers. We have designed several peptidomimetics to block the HER2-mediated dimerization, resulting in antiproliferative activity for cancer cells. In this work, we have investigated the structure-activity relationships of peptidomimetic analogs of Compound 5. Compound 5 was conformationally constrained by N- and C-terminal modification and cyclization as well as by substitution with d-amino acids at the N-and C-termini. Among the compounds studied in this work, a peptidomimetic Compound 21 with d-amino acid substitution and its N- and C-termini capped with acetyl and amide functional groups and a reversed sequence compared to that of Compound 5 exhibited better antiproliferative activity in HER2-overexpressed breast, ovarian, and lung cancer cell lines. Compound 21 was further evaluated for its protein-protein interaction (PPI) inhibition ability using enzyme fragment complementation assay, proximity ligation assay, and Western blot analysis. Results suggested that Compound 21 is able to block HER2:HER3 interaction and inhibit phosphorylation of the kinase domain of HER2. The mode of binding of Compound 21 to HER2 protein was modeled using a docking method. Compound 21 seems to bind to domain IV of HER2 near the PPI site of EGFR:HER2, and HER:HER3 and inhibit PPI.
The pitfalls of resuscitative endovascular balloon occlusion of the aorta: Risk factors and mitigation strategies (2017)

Despite technological advancements, REBOA is associated with significant risks due to complications of vascular access and ischemia-reperfusion. The inherent morbidity and mortality of REBOA is often compounded by coexisting injury and hemorrhagic shock. Additionally, the potential for REBOA-related injuries is exaggerated due to the growing number of interventions being performed by providers who have limited experience in endovascular techniques, inadequate resources, minimal training in the technique, and who are performing this maneuver in emergency situations. In an effort to ultimately improve outcomes with REBOA, we sought to compile a list of complications that may be encountered during REBOA usage. To address the current knowledge gap, we assembled a list of anecdotal complications from high-volume REBOA users internationally. More importantly, through a consensus model, we identify contributory factors that may lead to complications and deliberate on how to recognize, mitigate, and manage such events. An understanding of the pitfalls of REBOA and strategies to mitigate their occurrence is of vital importance to optimize patient outcomes.
Investigation into the genetics of fetal congenital lymphatic anomalies (2023)

WES identified pathogenic and likely pathogenic variants and VOUS in LA genes in 51% of fetal edema cases, supporting WES and expanded hydrops panels in cases of idiopathic fetal hydrops and fluid collections.
Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics (2020)

Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography with [<sup>18</sup>F]AV-1451 PET scanning to quantify Tau-dependent network changes. Using a graph theoretical approach to brain connectivity, we quantified nodal measures of functional segregation, centrality, and the efficiency of information transfer and tested them against levels of [<sup>18</sup>F]AV-1451. Higher Tau burden in early Alzheimer's disease was associated with a shift away from the optimal small-world organization and a more fragmented network in the beta and gamma bands, whereby parieto-occipital areas were disconnected from the anterior parts of the network. Similarly, higher Tau burden was associated with decreases in both local and global efficiency, especially in the gamma band. The results support the translational development of neurophysiological "signatures" of Alzheimer's disease, to understand disease mechanisms in humans and facilitate experimental medicine studies.
Hamiltonians for “Codimension One” Quasi-Crystals (1988)

Hamiltonians for quasi-crystalline tilings are considered. It is shown for tilings of codimension one that: a) if the interaction is of finite range, then quasi-crystals are unstable; b) long-range forces can stabilize quasi-crystals but only in the zero-measure regions of phase diagram.
System on silicon-IC for motion compensated scan rate conversion picture-in-picture processing, split screen applications and display processing (1999)

An IC (available commercially as the SDA9410) for consumer electronics TV sets performing 100 Hz interlaced/60 Hz progressive scan rate conversion has been designed. Picture-in-picture (PIP), split screen and picture improvement capabilities are also integrated. It applies a motion compensating algorithm for high-quality scan rate conversion. The PIP processing is performed using a full frame based scan rate conversion method. Split screen and multi-picture applications with two asynchronous input sources are supported. All field memories are included using a high performance embedded DRAM technology. Therefore the IC, which is compatible with current TV concepts, meets economical demands with increased functionality.
Supplementary Figure 1 from Optical Detection of Buccal Epithelial Nanoarchitectural Alterations in Patients Harboring Lung Cancer: Implications for Screening (2023)

Supplementary Figure 1 from Optical Detection of Buccal Epithelial Nanoarchitectural Alterations in Patients Harboring Lung Cancer: Implications for Screening
The cross-entropy method for power system combinatorial optimization problems (2007)

We present an application of a cross-entropy based combinatorial optimization method for solving some unit commitment problems. We report simulation results and analyze, under several perspectives (accuracy, computing times, ability to solve efficiently large-scale problems), the performances of the approach.
Solid-State Physics (2021)

Abstract This short chapter gives a glimpse of how concepts studied in other areas of physics, e.g., energy losses of ionizing particles in matter, connect to solid-state physics. The basic ideas behind transistors are discussed, and a topic of current research interest is introduced: creation of vacancies in diamond by electron irradiation. It is also shown that a lot about magnetic domains can be understood from “back-of-the-envelope” estimates.
Progress in development of controlled-clearance pressure balance in NMIJ (2010)

A new controlled-clearance pressure balance is under development with the aim of improving the hydraulic high-pressure standard up to 1 GPa. This pressure balance consists of three parts: (i) a pressure generation device up to 1 GPa, (ii) a weight-loading unit which can load/unload weights automatically and independently, (iii) a controlled-clearance piston-cylinder which is designed to allow the jacket pressure to be applied independently. Some adjustments were made for loading heavy weights on/off the piston safely, keeping them in balance, then generating the pressure stably. Stability of the generated pressure was checked for several piston-cylinders, and it was found that pressure fluctuation was less than a few parts per million. The jacket pressure coefficient of a 500 MPa controlled-clearance piston-cylinder was precisely evaluated as a function of both the system pressure and the jacket pressure.
Leukocyte Apoptosis and Mitochondrial Dysfunction in β-Thalassemia Patients Treated with Deferasirox or Deferoxamine. (2007)

Abstract Iron overload has been shown to increase mitochondrial dysfunction and apoptosis and may be implicated in leukocyte apoptosis. We assessed whether markers of leukocyte apoptosis and mitochondrial dysfunction are higher in iron-overloaded thalassemia patients compared with control subjects and whether improvement in the control of iron overload with deferasirox or deferoxamine (DFO) is associated with a change in the level of apoptotic markers. Methods: Thalassemia Clinical Research Network patients participating in the Novartis CICL670A0107 trial (a randomized comparison of deferasirox, an oral iron chelator, vs. DFO) were eligible and 44 (25 male, 21.8 yrs) were enrolled in the study. Fasting blood samples were obtainedafter a 5-day washout of DFO prior to commencing treatment with study drug, and24 hours post-chelator at 1, 6, and 12 months on study. Thirty healthy controls matched for age, sex, race and antioxidant usage (15 male, 24.5 yrs) also supplied a blood sample at baseline. After blood collection, plasma, serum and cells were separated by centrifugation. The pro-apoptotic marker Bax (an inducer of mitochondrial dysfunction) and the anti-apoptotic marker Bcl-2 were determined by ELISA. A high ratio of Bax/Bcl-2 indicates decreased stability of the mitochondrial outer membrane and increased potential for mitochondrial dysfunction and apoptosis. Activity of caspase–3 and −9 (both pro-apoptotic) were determined by a luminescent enzyme activity assay and reported as the average relative light units (RLU)/μg protein. Apoptotic markers were log-transformed prior to analysis and means and % change are reported. Results: At baseline, thalassemia patients had elevated Bax compared to the controls (17.4 vs. 11.6 pg/μg protein, p = 0.006). Similarly the activity of caspase-3 and −9 was high relative to the controls (for caspase-3, 1823 vs. 1041 RLU/μg protein, p = 0.01; and for caspase-9, 2482 vs. 1322 RLU/μg protein, p = 0.001). In longitudinal analysis, liver iron concentration and ferritin declined in both treatment groups (p ≤ 0.02 for both). This paralleled a decline in the ratio of Bax/Bcl-2 (–27.3% /yr, average decline, p = 0.033) and ALT (–7.3% /yr, average decline, p = 0.040). There was no significant difference between chelators in the rate of change of these markers over time. Conclusions: These findings demonstrate that markers of leukocyte apoptosis and mitochondrial dysfunction are high in thalassemia compared to controls and that the Bax/Bcl-2 ratio (a marker of mitochondrial dysfunction in apoptosis) decreased with effective iron chelation. DFO and deferasirox showed equal effectiveness in decreasing iron burden, ALT and the ratio of Bax/Bcl-2. Thus, with effective chelation, it may be possible to improve leukocyte and mitochondrial function and the levels of apoptosis.
Increased regional ventilation as early imaging marker for future disease progression of interstitial lung disease: a feasibility study (2022)

• Voxelwise correlation of serial CT scans suggests spatial correspondence between increased ventilation at baseline and structural changes at follow-up. • Regional assessment of pathologically increased ventilation at baseline has the potential to prospectively identify tissue at risk for developing fibrosis. • Presence and extent of pathologically increased ventilation may serve as an early imaging marker of disease activity.
Application of self-ionization for enhancing stereochemical and positional effects from arylglycosides under electron ionization conditions in an ion trap mass spectrometer (2003)

Ion trap mass spectrometry has been used to structurally characterize and differentiate positional and stereo isomers of arylglycosides having potential antioxidant properties. The use of the self-ionization (SI) technique has allowed to evidence a strong reactivity of fragment ions produced from dissociations of the molecular ion towards the molecules introduced into the trap. Specific structural effects due to positional isomers and anomers have been also envisaged through the occurrence of bimolecular processes inside the ion trap analyzer. Under self-ionization conditions, even-electron ions are produced. The charge is retained on the sugar moiety, in agreement with its proton affinity higher than that of the substituted phenol moiety. Most of the fragmentation pathways involve elimination of acetic acid that protects the hydroxylic groups of the glycoside. SI also produces adduct ions, likely as covalent species, having higher m/z values than the molecular ion. The reaction site is mainly the double bond present in the pyranosidic ring. Even if some fragment ions have lost the initial stereochemistry, their formation can be related to the structure of the parent neutrals introduced into the cell. Collision-induced dissociation (CID) experiments, carried out on ions formed by ion-molecule reactions, have allowed to obtain further information on gas phase ion structures. The study of mass-selected ion-molecule reactions and their kinetics have evidenced a spectacularly different reactivity of the ion at m/z 111 towards the two anomers 2alpha and 2beta, with the latter showing a much more pronounced reactivity. The approach developed in this work revealed to be an useful tool in structural characterization, as well as in stereo and regiochemical differentiation of arylglycosides.