gebhart/patrepeval huggingface dataset:
Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain (2003)

Mammalian short TRP channels (TRPCs) are putative receptor- and store-operated cation channels that play a fundamental role in the regulation of cellular Ca2+ homeostasis. Assembly of the seven TRPC homologs (TRPC1-7) into homo- and heteromers can create a large variety of different channels. However, the compositions as well as the functional properties of native TRPC complexes are largely undefined. We performed a systematic biochemical study of TRPC interactions in mammalian brain and identified previously unrecognized channel heteromers composed of TRPC1, TRPC4, or TRPC5 and the diacylglycerol-activated TRPC3 or TRPC6 subunits. The novel TRPC heteromers were found exclusively in embryonic brain. In heterologous systems, we demonstrated that assembly of these novel heteromers required the combination of TRPC1 plus TRPC4 or TRPC5 subunits along with diacylglycerol-sensitive subunits in the channel complexes. Functional interaction of the TRPC subunits was verified using a dominant negative TRPC5 mutant (TRPC5DN). Co-expression of TRPC5DN suppressed currents through TRPC5- and TRPC4-containing complexes; TRPC3-associated currents were unaffected by TRPC5DN unless TRPC1 was also co-expressed. This complex assembly mechanism increases the diversity of TRPC channels in mammalian brain and may generate novel heteromers that have specific roles in the developing brain.
Multivoxel pattern analysis of chromatic responses in LGN and V1 (2010)

Behavioural measurements have repeatedly shown that the four unique hues are different from the chromatic mechanisms found in the Lateral Geniculate Nucleus (LGN), a sub-cortical structure involved in visual processing: the cone-opponent LGN mechanisms (i.e. cardinal directions ‘L-M’ and ‘S-(L+M)’) do not map onto the colours human observers usually label as red, green, yellow, and blue. Unique hues must therefore be encoded at a later processing stage, in the primary visual cortex or in the extrastriate visual areas. We use multi-voxel pattern analysis (MVPA) to study the spatial clustering of color-selective neurons in the human brain. Our main objective was to investigate whether MVPA reveals the spatial arrangements of color-selective neurons in LGN and in human primary visual cortex (V1). We measured the distributed fMRI activation patterns for different color stimuli (Experiment 1: cardinal colors (to which the LGN is known to be tuned), Experiment 2: unique hues) in LGN and V1. Our main findings were: (i) In LGN, cone-opponent cardinal directions produce unique activation patterns for each of the three cardinal colour directions. (ii) Cone-opponent cardinal color modulations produce highly reproducible patterns of activity in V1, but these were not unique to each color. These results suggests that V1 neurons with tuning characteristics similar to those found in LGN are not spatially clustered. (iii) Unique activation patterns for perceptual (unique) hues in V1 support current evidence for a spatially clustered hue map.
Analysis of influence of seepage on stability of foundation pit (2017)

Numerical analysis is executed to deep foundation pit by using the finite element software. In combination with the site data, the consequences with the consideration of groundwater seepage are contrasted to the consequences without the consideration of groundwater seepage including the stability of the foundation pit. The analysis indicates that the result with the consideration of seepage is relatively close to the site data. Compared with the result without consideration of groundwater seepage, the maximum horizontal offset of the pile increases approximate 5mm and the location of the maximum horizontal displacement moves 2m down. So seepage is harmful to the retaining structure of foundation pit and should be considered in the design of foundation pit.
Invariant Deletion of One Mir-34b/C Locus in CLL with del11q. (2008)

Abstract CLL with del11q constitutes a clinical syndrome characterized by a relatively aggressive disease course, short response duration to therapies and compromised overall survival. CLL with del11q carries mutations in ATM in about one third of cases, which may further negatively affect prognosis. Little is known about additional molecular changes within or due to del11q in CLL and it remains unclear what the selective advantage of acquisition of del11q is for CLL cells. To gain insights into the physiology of CLL with del11q, we have mapped this lesion using the Affymetrix 50K SNP array platform in 178 CLL cases using DNA from sorted CD19+ cells versus paired buccal DNA. Focusing on the region that spans ATM, a minimal deleted region (MDR) of approximately 8 Mb was identified, spanning approximately 106.6–114.6 Mb physical position. Scanning the MDR for genes with the potential to affect the physiology of cancerous cells uncovered invariant monoallelic deletion of the miR-34b/c gene, the only known human microRNA gene within the del11q MDR. miR-34a-c have been implicated as direct p53 target genes by a number of groups and these microRNAs have been shown to be direct regulators of pro-proliferative and anti-apoptotic genes, including E2F3, Cyclin E2, Cdk6 and Bcl2. Given that ATM acts upstream of p53 in the ds-DNA damage response pathway, it appears that del11q lesions in CLL affect p53 apoptotic effector functions through two independent processes (ATM loss or mutation and miR-34b/c loss). Work is in progress measuring miR-34 b/c expression levels in a large CLL cohort and correlating miR-34b/c levels with expression levels of critical miR-34 targets in CLL. In summary, our data implicate miR-34b/c loss as a potential contributor to the physiology of del11q in CLL and should stimulate investigations into miR-34 function as a response predictor of therapy for CLL.
Synthese und Struktur der Nitridokomplexe(Ph3Sb)2Cl3Os≡≡N-RhCl(COD),(Me2PhP)2(PhCN)Cl2Re≡≡N-RhCl2(C5Me5),[(Me2PhP)3(PhCN)ClRe≡≡N-OsCl2(CO)3][OsCl3(CO)3] und[(Me2PhP)3(PhCN)ClRe≡≡N-ReCl4-N≡≡ReCl(NCPh)(PMe2Ph)3][OsCl4(CO)2] (2003)

The reaction of (Ph 3 Sb) 2 Cl 3 OsN with [Rh(μ-Cl)(COD)] 2 in benzonitrile yields the heteronuclear nitrido complex (Ph 3 Sb) 2 Cl 3 Os≡N-RhCl(COD) (1). It crystallizes as dark brown blocks in the triclinic space group P1 witha = 1080.09(5), b = 1173.15(5), c = 1702.28(9) pm, α = 101.214(4), β = 92.923(8), y = 92.836(5)°, and Z = 2. The complex fragment RhCl(COD) is coordinated to the osmium nitrido complex via a linear nitrido bridge Os≡N-Rh, with a bond angle Os-N-Rh = 175.3(5)° and distances Os-N = 168.6(6) and Rh-N = 184.6(6) pm. The heteronuclear complexes (Me 2 PhP) 2 (PhCN)Cl 2 Re≡N-RhCl 2 (C 5 Me 5 ) (2) and [(Me 2 PhP) 3 (PhCN)ClRe≡N-OsCl 2 (CO) 3 ][OsCl 3 (CO) 3 ] (3) are obtained by the reaction of (Me 2 PhP) 3 Cl 2 ReN with [RhCl(μ-Cl)(C 5 Me 5 )] 2 and [OsCl(μ-Cl)(CO) 3 ] 2 , respectively, in benzonitrile. 2 forms orange red crystals with the composition 2.C 6 H 5 CN in the monoclinic space group P2 1 /c and a = 910.23 (7), b = 1255.4(1), c = 3761.5(3) pm, β = 95.617(9)° and Z = 4. The nitrido bridge Re≡N-Rh to the complex fragment [RhCl 2 (C 5 Me 5 )] has a bond angle Re-N-Rh of 171.9(3)° and distances Re-N = 169.4(5) and Rh-N = 201.9(5) pm. 3 forms yellow orange plates with the monoclinic space group P2 1 /c and a = 1113.74(5), b = 2038.5(2), c = 2130.1(1) pm, β = 90.298(6)° and Z = 4. The nitrido bridge within the complex cation [(Me2PhP)3(PhCN)ClRe≡N-OsCl 2 (CO)3]+ is characterized by a bond angle Re-N-Os of 167.7(4)° and distances Re-N = 169.5(8) and Os-N = 206.1(8) pm. The ligands of the octahedral anion [OsCl 3 (CO) 3 ] - are in a facial arrangement. The synthesis of 3 yields [{(Me 2 PhP) 3 (PhCN)ClRe≡N} 2 ReC 4 ][OsCl 4 (CO)2] (4) as a byproduct. It crystallizes as red brown blocks with the composition 4.CH 2 Cl 2 in the space group P1 and a = 1444.2(1), b = 1536.3 (1), c = 2150.5(2) pm, α=87.41(1), β=88.54(1), γ=62.453(8)° and Z = 2. In the two symmetry independent, centrosymmetric cations [(Me 2 PhP) 3 (PhCN)ClRe≡N-ReCl 4 -N≡ReCl(NCPh)(PMe 2 Ph) 3 ] 2 + of 4 two nitrido complexes [(Me 2 PhP) 3 (PhCN)ClReN] + coordinate with their terminal nitrido ligands a central, square planar ReCl 4 unit. The resulting nitrido bridges with bond angles Re(1)-N(1)-Re(2) = 167.0(4)° and Re(3)-N(2)-Re(4) = 168.9(4)°, respectively, exhibit distances Re(1)-N(1) = 172.4(7) and Re(2)-N(1) = 197.1(7) or Re(3)-N(2) = 171.4(6) and Re(4)-N(2) = 197.1(6) pm. The two carbonyl ligands of the anion [OsCl 4 (CO) 2 ] 2 - are in cis position.
Characterizing Full-Duplex V2V Broadcast Performance through Stochastic Geometry (2019)

Broadcast traffic in IEEE 802.11 vehicular networks is known to suffer from poor performance due to the lack of recovery mechanisms from packet losses, based on the rules of the Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) protocol. This may have a detrimental impact on cooperative vehicular safety applications that build on the reliable regular broadcasting of status messages by vehicles in a local neighborhood. Full-Duplex (FD) techniques can improve the broadcast CSMA/CA performance by letting a sending vehicle sense the channel while transmitting, thus enabling “collision detection”. The vehicle, consequently, can abort the packet prone to collision and reattempt a later transmission. In this paper, we define a stochastic geometry model that captures the collision detection capability of FD-enabled vehicles, while accurately characterizing the interference power generated by other vehicles on a road segment, and the dynamics of the backoff mechanism used for broadcast packet retransmissions. The model provides helpful insights into the FD broadcast CSMA/CA behaviour, highlighting a clear relationship between the settings for the carrier sense threshold and the collision detection threshold and the number of covered receivers on the road.
An Introduction to the Analysis of Linkage-Driven Compliant Underactuated Fingers (2006)

This paper presents an analysis of a two-phalanx linkage-driven underactuated finger with substantial compliance in all the joints of the system. The primary goal of the paper is to illustrate with an example, the theoretical issues faced in designing compliant underactuated fingers. To this aim, a two-phalanx linkage-driven underactuated finger is analyzed throughout the paper to clarify the concepts presented. First, a method to compute the contact forces generated by compliant underactuated fingers is presented and discussed. Finally, the self-mobility of the finger is discussed and a method to predict if this mobility will converge to a stable grasp or not is presented. The paper presents an exemplified theoretical analysis whose layout provides very useful insights for the design of compliant underactuated fingers and emphasizes the challenges to be met in order to design successful prototypes.
Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury (2022)

These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients.
Chronic myelocytic leukemia: eosinophils involved in the malignant clone (1980)

Chronic myelocytic leukemia (CML) is a clonal disorder involving neutrophil, monocyte, erythrocyte, and platelet precursors. In order to determine if the eosinophils are also involved in the leukemic clone, we purified the eosinophils from a woman heterozygous for the common electrophoretic variants of the G6PD gene. Only type B enzyme was demonstrable in the eosinophils, neutrophils, and red cells, but both A and B enzymes were found in the fibroblasts. The data provide evidence that the eosinophil is involved in the malignant clone.
Structure and Immune Recognition of the HIV Glycan Shield (2018)

Vaccine design efforts against the human immunodeficiency virus (HIV) have been greatly stimulated by the observation that many infected patients eventually develop highly potent broadly neutralizing antibodies (bnAbs). Importantly, these bnAbs have evolved to recognize not only the two protein components of the viral envelope protein (Env) but also the numerous glycans that form a protective barrier on the Env protein. Because Env is heavily glycosylated compared to host glycoproteins, the glycans have become targets for the antibody response. Therefore, considerable efforts have been made in developing and validating biophysical methods to elucidate the complex structure of the Env-spike glycoprotein, with its combination of glycan and protein epitopes. We illustrate here how the application of robust biophysical methods has transformed our understanding of the structure and function of the HIV Env spike and stimulated innovation in vaccine design strategies that takes into account the essential glycan components.
Resolution Constraints in Web Real Time Communications (2013)

This document specifies the constraints necessary for a Javascript
application to successfully indicate to a browser that supports WebRTC
what resolutions it desires on a video stream. It also discusses the
possible use of SDP to carry that information between browsers.
Saxophone acoustics and marching bands (2017)

Historically saxophones appear in bands far after the beginning of Jazz history. Marching bands were mainly built around brass instruments and the saxophone appears alone in these bands. The main question that arises is “how this brass-woodwind succeeded to mix in such brass bands? The power of brass instruments is known to cover most woodwinds but the saxophone survives when flutes, with the exception of piccolo, disappeared. The answer could be in the design of saxophone and mainly in the design of tenor saxophone. The saxophone has been built and designed by A. Sax to be a powerful instrument able to cover or to compete with the sound of brass instruments, and he has been successful. We will show that in addition with the native sound power of its side, the saxophone exhibits a formant in the most sensitive part of our hearing system that gives it such “voicy” sound. Finally, we will show that saxophones are as wild instruments as the other members of marching bands with theses two characteristics power and voice.
GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children (2005)

The role of all-trans retinoic acid (ATRA) in pediatric acute promyelocytic leukemia (APL) is the topic of several ongoing studies. The results of the Italian pediatric experience with the multicentric Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA)-Italian Pediatric Hematology and Oncology Group (AIEOP) "AIDA" (ATRA and idarubicin) trial are presented. Of the 983 patients with APL enrolled in this protocol between January 1993 and June 2000, 124 (13%) had younger than 18 years. Treatment consisted of ATRA and idarubicin induction followed by 3 polychemotherapy consolidation courses. Molecular response by reverse transcriptase-polymerase chain reaction (RT-PCR) was assessed after consolidation and patients who were PCR- were randomized for different maintenances. One hundred and seven children were eligible and evaluable for induction: 103 (96%) achieved a hematologically complete remission. Overt ATRA syndrome was observed in 2 patients and pseudotumor cerebri was observed in 10 patients. Ninety-four patients were evaluable for RT-PCR analysis at the end of consolidation: 91 (97%) proved PCR+ and 3 PCR-. The overall survival and event-free survival (EFS) are 89% (95% confidence interval [c.i.]: 83%-95%) and 76% (c.i.: 65%-85%), respectively, at more than 10 years. A white blood cell (WBC) count at diagnosis of greater than 10 x 10(9)/L had a significant impact on EFS (59% vs 83% at 10 years). These results highlight the efficacy and feasibility of the AIDA protocol in the pediatric APL population.
Nucleotide Analog Interference Mapping (2015)

Methods collectively known as modification interference are exceptionally powerful approaches used to identify functionally important chemical groups in the phosphodiester backbone or nucleobases of an RNA. In a modification interference assay, end-labeled RNAs that have been modified at different positions are allowed to participate in a reaction of interest, and then functional RNA molecules (e.g., those bound by protein or that successfully participate in a processing reaction) are separated from nonfunctional RNA molecules (e.g., those not bound by protein or unable to participate in a processing reaction). Nucleotide analog interference mapping (NAIM) involves the incorporation of α-thionucleotides containing a modified base into the RNA molecule of interest. The sites containing the modified base are identified by cleavage with iodoethanol. NAIM is useful whenever the thiophosphate substitution on its own does not prevent or inhibit a specific reaction. To perform NAIM, it is first necessary to perform a thiophosphate interference analysis. Any positions that are not affected by thiophosphate substitution can then be analyzed by NAIM.
A Neural Network for Quality of Experience Estimation in Mobile Communications (2016)

High data rates are usually envisaged by operators to satisfy the subscribers using multimedia services. However, due to the increasing number of tablets, smartphones, and push applications, user needs can require low throughput. A new analysis of user satisfaction is necessary--the so-called quality of experience (QoE). The authors consider specific key performance indicators (KPIs) and propose using neural networks to provide an automatic classification among these KPIs (related to quality of service) and QoE. The adoption of the neural network ensures replicability of QoE estimation regardless of user involvement and simplifies QoE analysis for future communications systems.
Optical cavity effects in InGaN/GaN quantum-well-heterostructure flip-chip light-emitting diodes (2003)

Optical cavity effects have a significant influence on the extraction efficiency of InGaN/GaN quantum-well-heterostructure flip-chip light-emitting diodes (FCLEDs). Light emitted from the quantum well (QW) self-interferes due to reflection from a closely placed reflective metallic mirror. The interference patterns couple into the escape cone for light extraction from the FCLED. This effect causes significant changes in the extraction efficiency as the distance between the QW and the metallic mirror varies. In addition, the radiative lifetime of the QW also changes as a function of the distance between the QW and the mirror surface. Experimental results from packaged FCLEDs, supported by optical modeling, show that a QW placed at an optimum distance from the mirror provides a ∼2.3× increase in total light output as compared to a QW placed at a neighboring position corresponding to a minimum in overall light extraction.
Time-Resolved Grazing-Incidence Diffraction Studies of Thin Films Using an Imaging-Plate Camera and Focusing Monochromator (1998)

A multiple imaging-plate (IP) detector system and focusing monochromator have been developed and successfully applied to the time-resolved study of phase transitions in Langmuir-Blodgett (LB) films by grazing-incidence X-ray diffraction (GIXD). The first reported application of imaging plates to a GIXD study was carried out by our group and proved to be very successful in the determination of thin-film structure [Foran, Peng, Steitz, Barnes & Gentle (1996). Langmuir, 12, 774-777]. To extend the capabilities of this system, an IP camera was designed and built which can accommodate up to 13 IPs (40 x 20 cm) inside the vacuum chamber of the main diffractometer at the Australian Beamline at the Photon Factory. The camera allows the enclosed IPs to be successively exposed and stored inside the diffractometer for later scanning. The focusing monochromator employed in this technique combines fixed exit-beam height with sagittal focusing of the second crystal and delivers a gain in flux of >/=20 times when measured through a 0.1 x 0.1 mm aperture. The utility of the system incorporating the IP camera and the focusing monochromator has been demonstrated through the study of temperature-dependent phase transitions in LB films of metal fatty acids.
Computational efficiency improvements for image colorization (2014)

We propose an efficient algorithm for colorization of greyscale images. As in prior work, colorization is posed as an optimization problem: a user specifies the color for a few scribbles drawn on the greyscale image and the color image is obtained by propagating color information from the scribbles to surrounding regions, while maximizing the local smoothness of colors. In this formulation, colorization is obtained by solving a large sparse linear system, which normally requires substantial computation and memory resources. Our algorithm improves the computational performance through three innovations over prior colorization implementations. First, the linear system is solved iteratively without explicitly constructing the sparse matrix, which significantly reduces the required memory. Second, we formulate each iteration in terms of integral images obtained by dynamic programming, reducing repetitive computation. Third, we use a coarseto- fine framework, where a lower resolution subsampled image is first colorized and this low resolution color image is upsampled to initialize the colorization process for the fine level. The improvements we develop provide significant speedup and memory savings compared to the conventional approach of solving the linear system directly using off-the-shelf sparse solvers, and allow us to colorize images with typical sizes encountered in realistic applications on typical commodity computing platforms.
Integrated System for the Parallel Detection of Multiple Antibiotics in Milk (2008)

Although the fractures of femoral neck are not so common, their accompanying complications are more frequent and important. This research aims at studying the results of reverse triangle screw fixation in patients suffering from femoral neck fractures in two groups with perfect and imperfect position of the mentioned screw. In a cohort study, 51 patients with femoral neck fracture appointed for the so-called reverse triangle screw fixation were divided into two perfect and imperfect groups considering surgeon comment on position of the screws. The patients were followed up for 12 months and the resulted outcomes were compared. There were 34 patients in the perfect group with mean age of 48.7 +/- 18.6 (18-80) and 17 patients in the imperfect group with mean age of 50.4 +/- 15.9 (19-80) years old. Both groups were the same considering underlying causes and fraction grades. The overall frequency of nonunion and avascular necrosis was 7.8 and 3.9%, respectively. These rates were 2.9 and 0% in the perfect group and 17.6 and 12.5% in the imperfect group, respectively (p > 0.05). The mean Harris hip score and motion range of the hip at different directions in the perfect group were substantially higher than those of the imperfect one. According to present results, position of the screws determined by the surgeon after operating the reverse triangle screw fixation in femoral neck fractures may significantly affect the prognosis of patients.