gebhart/patrepeval huggingface dataset:
Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator (2001)

The Quebec platelet disorder (QPD) is an autosomal dominant platelet disorder associated with delayed bleeding and alpha-granule protein degradation. The degradation of alpha-granule, but not plasma, fibrinogen in patients with the QPD led to the investigation of their platelets for a protease defect. Unlike normal platelets, QPD platelets contained large amounts of fibrinolytic serine proteases that had properties of plasminogen activators. Western blot analysis, zymography, and immunodepletion experiments indicated this was because QPD platelets contained large amounts of urokinase-type plasminogen activator (u-PA) within a secretory compartment. u-PA antigen was not increased in all QPD plasmas, whereas it was increased more than 100-fold in QPD platelets (P <.00009), which contained increased u-PA messenger RNA. Although QPD platelets contained 2-fold more plasminogen activator inhibitor 1 (PAI-1) (P <.0008) and 100-fold greater u-PA-PAI-1 complexes (P <.0002) than normal platelets, they contained excess u-PA activity, predominantly in the form of two chain (tcu-PA), which required additional PAI-1 for full inhibition. There was associated proteolysis of plasminogen in QPD platelets, to forms that comigrated with plasmin. When similar amounts of tcu-PA were incubated with normal platelet secretory proteins, many alpha-granule proteins were proteolyzed to forms that resembled degraded QPD platelet proteins. These data implicate u-PA in the pathogenesis of alpha-granule protein degradation in the QPD. Although patients with the QPD have normal to increased u-PA levels in their plasma, without evidence of systemic fibrinogenolysis, their increased platelet u-PA could contribute to bleeding by accelerating fibrinolysis within the hemostatic plug. QPD is the only inherited bleeding disorder in humans known to be associated with increased u-PA.
Efficient multicast packet authentication using signature amortization (2005)

We describe a novel method for authenticating multicast packets that is robust against packet loss. Our main focus is to minimize the size of the communication overhead required to authenticate the packets. Our approach is to encode the hash values and the signatures with Rabin's Information Dispersal Algorithm (IDA) to construct an authentication scheme that amortizes a single signature operation over multiple packets. This strategy is especially efficient in terms of space overhead, because just the essential elements needed for authentication (i.e., one hash per packet and one signature per group of packets) are used in conjunction with an erasure code that is space optimal. To evaluate the performance of our scheme, we compare our technique with four other previously proposed schemes using analytical and empirical results. Two different bursty loss models are considered in the analyses.
Thin-Plate Splines For Printer Data Interpolation (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Eye Movements in Dyslexia (1985)

The study of eye movements during reading has provided many important insights about the process of reading. Until recently, there has been a relatively broad consensus that the erratic eye movements of poor readers were a consequence of difficulties in learning the visual-verbal associations involved in reading, rather than being a primary cause of poor reading themselves. However, recent data has begun to question this assumption. In this month's Topical Review, the author reviews the research suggesting the erratic eye movements of dyslexics are not simply a consequence of poor reading skills. This research is important because, if it is substantiated in future work, examination of eye movement patterns may contribute significantly to the diagnosis of dyslexia. —J.K.T.
Experimental and numerical investigation on the open-hole compressive strength of AFP composites containing gaps and overlaps (2017)

Laminated composite structures manufactured via the automated fiber placement process inherently contain process defects know as gaps and overlaps. These defects raise concerns when they are located on or near holes intended for mechanical fastening. This investigation attempts to predict the effect of automated fiber placement-generated defects on the open-hole compression strength by combining both experimental tests and numerical simulation. Tested open-hole compression specimens containing gaps and overlaps oriented at 0° or 90° and centered on or shifted near the hole show that, depending on their location, the gaps and overlaps may have negative, negligible, or positive effects on the open-hole compression strength. The better than expected effects are compatible with microscopic observations that clearly show the rearrangement of the plies during the consolidation process, which prevent the formation of deleterious discontinuities. Incorporating these observations in a numerical model, which simulates gaps and overlaps embedded inside the composite laminates, and applying a progressive failure analysis, confirms that the effects of automated fiber placement defects depend as much on their type as on their location relative to the hole center. Finally, the results obtained from a parametric study provided further explanation on the effects of automated fiber placement defects on the failure strength of perforated composite laminates.
Ecalectin as a T Cell-Derived Eosinophil Chemoattractant (1999)

In our previous papers, we have shown that human T cells produce a unique eosinophil chemotactic factor (ECF), termed Ecalectin, with a molecular weight of about 30-50 kD during interaction with BALL-1 (a B cell line) extracts, antigen or mitogen. A 1.6-kB cDNA was isolated from a human T cell-derived expression library that encodes Ecalectin. Ecalectin is a 36-kD protein consisting of 323 amino acids based on its deduced amino acid sequence. Ecalectin was found to be a variant of human galectin-9, a member of the growing family of animal lectins exhibiting affinity for beta-galactosides. Recombinant Ecalectin, expressed in COS cells, exhibited potent ECF activity in vitro and in vivo in a dose-dependent manner but not chemotactic activity for neutrophils, lymphocytes, or monocytes. The finding that the Ecalectin transcript is present in various lymphatic tissues and that its expression increases substantially in antigen-activated peripheral blood mononuclear cells suggests that Ecalectin is an important T cell-derived regulator of eosinophil recruitment in allergic reaction sites.
Design of π-Conjugated Organic Materials for One-Dimensional Energy Transport in Nanochannels (2005)

Various end-substituted distyrylbenzenes have been synthesized to serve as guest molecules in inclusion compounds to promote efficient energy transport along one-dimensional channels. Their optical and photophysical properties have been characterized at both experimental and theoretical levels. All molecules display a large transition dipole moment between the ground state and lowest excited state and hence a short radiative lifetime (on the order of 1-2 ns). They also exhibit a large spectral overlap between the emission and absorption spectra, which enables efficient energy transport between molecules arranged in a head-to-tail configuration in nanochannels. Hopping rates on the order of 10(12) s(-1) are calculated at a full quantum-chemical level; this is much larger than the radiative lifetimes and opens the way for energy migration over large distances. Changes in the nature of the terminal substituents are found to modulate the optical properties weakly but to impact significantly the energy transfer rates.
The Effects of Surgically Removing Subcutaneous Fat on the Metabolic Profile and Insulin Sensitivity in Obese Women after Large-Volume Liposuction Treatment (2002)

The aim of this study was to identify the effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large-volume liposuction treatment. An open clinical trial with a non-intervention parallel group was carried out on 12 young, obese women. After randomization, six volunteers were selected to the surgical intervention consisting of large-volume liposuction; the other six women were considered as the non-intervention group. Metabolic profiles and insulin tolerance tests to assess insulin sensitivity were performed on all volunteers before intervention or non-intervention and 21 - 28 days afterwards. There were a significant decrease in glucose (4.9 +/- 0.4 vs. 4.6 +/- 0.2 mmol/l, p < 0.05) and uric acid (250.8 +/- 56.2 vs. 224.0 +/- 53.4 micromol/l, p < 0.05) levels after liposuction; insulin sensitivity improved after the surgical intervention (4.3 +/- 0.9 vs. 5.3 +/- 0.8 %/min, p = 0.046). In conclusion, surgical removal of subcutaneous fat by large-volume liposuction led to an improvement in insulin sensitivity and a decrease in glucose and uric acid concentrations.
Principes des télécommunications analogiques et numériques (2008)

AvertissementLa matire de ce cours a fortement volu ces dernires annes.Par contre, depuis 2013, ces notes n'ont plus t mises jour ; la matire connatre pour l'examen est dtermine par le contenu des transparents et non les notes.En consquence, il est primordial de se baser sur les transparents du cours pour l'tude du cours et la prparation l'examen.Nanmoins, ces notes peuvent complter les explications du cours pour certains chapitres.Pour la facilit, la matire essentielle est reprise dans le corps principal du texte ; certaines annexes fournissent un complment d'information.2.2.5.Systme de transmission idal . . . . . . .
Peroxide detected in imidazolium-based ionic liquids and approaches for reducing its presence in aqueous and non-aqueous environments (2015)

Peroxide species appearing in imidazolium-based ionic liquids could be removed by salen–manganese complexes or the enzyme catalase.
Temperature Extremes in the Community Atmosphere Model with Stochastic Parameterizations* (2015)

Abstract This paper evaluates the performance of the NCAR Community Atmosphere Model, version 4 (CAM4), in simulating observed annual extremes of near-surface temperature and provides the first assessment of the impact of stochastic parameterizations of subgrid-scale processes on such performance. Two stochastic parameterizations are examined: the stochastic kinetic energy backscatter scheme and the stochastically perturbed parameterization tendency scheme. Temperature extremes are described in terms of 20-yr return levels and compared to those estimated from ERA-Interim and the Hadley Centre Global Climate Extremes Index 2 (HadEX2) observational dataset. CAM4 overestimates warm and cold extremes over land regions, particularly over the Northern Hemisphere, when compared against reanalysis. Similar spatial patterns, though less spatially coherent, emerge relative to HadEX2. The addition of a stochastic parameterization generally produces a warming of both warm and cold extremes relative to the unperturbed configuration; however, neither of the proposed parameterizations meaningfully reduces the biases in the simulated temperature extremes of CAM4. Adjusting warm and cold extremes by mean conditions in the respective annual extremes leads to good agreement between the models and reanalysis; however, adjusting for the bias in mean temperature does not help to reduce the observed discrepancies. Based on the behavior of the annual extremes, this study concludes that the distribution of temperature in CAM4 exhibits too much variability relative to that of reanalysis, while the stochastic parameterizations introduce a systematic bias in its mean rather than alter its variability.
Design and basic characteristics of permanent magnet hybrid type axial magnetic bearings (2010)

In order to improve rotor-impeller suspension performance of the developing ventricular assist device, axial magnetic bearing with various permanent magnet arrangements are designed and fabricated. Separate permanent magnets type stator shows wide linear range and improved force characteristics.
Tunable Delay Lines in Silicon Photonics: Coupled Resonators and Photonic Crystals, a Comparison (2010)

In this paper, we report a direct comparison between coupled resonator optical waveguides (CROWs) and photonic crystal waveguides (PhCWs), which have both been exploited as tunable delay lines. The two structures were fabricated on the same silicon-on-insulator (SOI) technological platform, with the same fabrication facilities and evaluated under the same signal bit-rate conditions. We compare the frequency- and time-domain response of the two structures; the physical mechanism underlying the tuning of the delay; the main limits induced by loss, dispersion, and structural disorder; and the impact of CROW and PhCW tunable delay lines on the transmission of data stream intensity and phase modulated up to 100 Gb/s. The main result of this study is that, in the considered domain of applications, CROWs and PhCWs behave much more similarly than one would expect. At data rates around 100 Gb/s, CROWs and PhCWs can be placed in competition. Lower data rates, where longer absolute delays are required and propagation loss becomes a critical issue, are the preferred domain of CROWs fabricated with large ring resonators, while at data rates in the terabit range, PhCWs remain the leading technology.
Grazing affects methanotroph activity and diversity in an alpine meadow soil (2009)

The role of methane-oxidizing bacteria (MOB) in alpine environments is poorly understood, but is of importance given the abundance of alpine environments and the role of MOB in the global carbon cycle. Using a combination of approaches we examined both seasonal and land usage effects on the ecology of microbial methane oxidation in an alpine meadow soil. Analysis of the abundance and diversity of MOB demonstrated that the abundance and diversity of the dominant type II MOB, predominantly Metylocystis and relatives, was only influenced by season. Conversely type Ia MOB abundance was significantly affected by season and land usage, while diversity changes were effected predominantly by land use. Assessment of methane oxidation potential and soil physical properties demonstrated a strong link between type Ia MOB abundance and methane oxidation potential as well as a complex series of relationships between soil moisture, pH and MOB abundance, changing with season. The results of this study suggest that, while type II MOB, unaffected by land use, represent the dominant MOB, Methylobacter-related type Ia MOB appear to be responsible for the majority of methane oxidation and are strongly affected by the grazing of cattle.
Application of Wireless Sensor Network for the Monitoring Systems of Vessels (2012)

This chapter studies the feasibility of WSN on board ships. Several measurement campaigns are conducted on board a ferry-boat to verify the possibility of wireless communications between ship parts and to analyse the performance of WSN on board. These measurements aim at determining path loss models for typical shipboard environments and testing the possibility of wireless communication between adjacent rooms or adjacent decks. Using the results of these experiments, a WSN is tested on board the ferry. The results obtained from the measurement campaigns are then used to propose an architecture for a large-scale shipboard WSN. As the network test uses a limited number of nodes, the full monitoring system based on the proposed architecture is simulated using a network simulator.
Chip Embedding for Printed Circuit Boards and Subsystems (2010)

The reason for chip embedding by means of PCB technology are manifold. Actually there are several emerging technologies on the market which all face one common problem: To realize the escape routing of a high pin count die one has to use several build up layers or very fine lines &amp; spaces for the PCB. Both approaches have a significant influence on the cost of a electrical component because both solutions raise the manufacturing complexity. Due to this problem approaches like “chip first” or “chip last” are being discussed in plenty of papers. With this paper, an alternative way of producing embedded systems is mentioned, which overcomes many of the actual problems.
Acadesine: Prototype adenosine regulating agent for treating myocardial ischemia‐reperfusion injury (1993)

Abstract Acadesine is an adenosine regulating agent currently being developed for treatment of ischemia‐reperfusion injury in the setting of cardiac surgery. While the cardioprotective effects of adenosine are well recognized, the intrinsic hemodynamic and cardiac effects of adenosine limit its potential usefulness as a therapeutic agent. In contrast, acadesine has been shown to elevate endogenous levels of adenosine during periods of ischemia without exhibiting systemic hemodynamic action. The site‐specific and event‐specific mechanism of action thus provides cardioprotection without the adverse sequelae commonly observed with adenosine. This review describes the pertinent literature which establishes acadesine's action as an adenosine regulating agent, and discusses past and recent studies which focus on the cardioprotective actions of acadesine. These studies include in vitro and in vivo models of regional and global ischemia, and models of cardiac surgery. Aspects of dose‐response, timing of administration, and pharmacokinetics of acadesine are described which reconcile prior controversy regarding acadesine'e cardioprotective actions. These studies, taken together, demonstrate that acadesine is the prototype of a new class of adenosine regulating agents useful as therapy for cardiac ischemia. © 1993 Wiley‐Liss, Inc.
Novel Balanced Coupled-Line Bandpass Filters With Common-Mode Noise Suppression (2007)

Novel balanced coupled-line bandpass filters, using suitable balanced coupled-line sections and quarter-wavelength resonators, are proposed. For design purposes, the differential- and common-mode equivalent half-circuits are established. Based on these circuits, a better balanced filter structure is implemented so that the desired differential-mode response may be realized and the level of common-mode noise may be minimized simultaneously. Besides, a suitable capacitive or inductive cross-coupled effect is introduced so as to create two transmission zeros for improving the filter selectivity; however, it also enhances the signal imbalance and degrades the common-mode rejection. In this study, various second- and fourth-order balanced filters are implemented to discuss the associated differential-mode responses and the signal-imbalance phenomena resulted from the cross-coupled effect. Specifically, the fourth-order filter with a common-mode rejection ratio of 40 dB within the passband is demonstrated and examined
Enhanced Production of Mouse Mammary Tumor Virus in DexamethasoneTreated, 5-Iododeoxyuridine-Stimulated Mammary Tumor Cell Cultures 2 (1974)

The production of virus-related RNA-dependent DNA polymerase, cell-associated mouse mammary tumor virus (MMTV) antigens, and B particles by 5-iododeoxyuridine in C3H mouse mammary tumor cell cultures was enhanced by dexamethasone, a synthetic glucocorticoid hormone. This enhancement further implicates hormones in MMTV replication and provides the basis for an in vitro MMTV production system.
A comparison of software code reordering and victim buffers (1999)

No abstract available.
Constructing and conceptualising suicide and self-harm (2022)

In this chapter, the authors provide an overview of suicide and self-harm, with particular reference to social theory, epidemiology, societal attitudes, law and ethics, and management strategies. Against a background of their research and clinical experience of working in community and residential settings, the authors present a specific examination of self-harm and suicide grounded in theory and practice, taking account of both societal- and individual-level analyses. The aim is to explore the conceptualisation of suicide and self-harm and related empirical data.
Effect of Chlorhexidine/Silver Sulfadiazine-Impregnated Central Venous Catheters in an Intensive Care Unit with a Low Blood Stream Infection Rate after Implementation of an Educational Program: A Before–After Trial (2007)

Although chlorhexidine/silver sulfadiazine-impregnated catheters are useful in specific patient populations, they did not result in a statistically significant decrease in the CR-BSI rate in this study, beyond what was achieved with education alone.
Antigen Unmasking in Formalin-Fixed Routinely Processed Paraffin Wax-Embedded Sections by Pressure Cooking (1995)

Miller, K; Auld, J.; Jessup, Eileen; Rhodes, A.; Ashton-Key, Margaret Author Information
A low-heat-leak support structural member for the superconducting Chicago Cyclotron Magnet (1982)

This paper reports on the successful building of a support structure capable of high mechanical load and low heat leak. The structure contributed much to the achievement of the low LHe usage rate of the Chicago Cyclotron Magnet and therefore to the success of the project. The design of the single column is desbribed with a schematic drawing. Prototype testing is presented in terms of compression, testing, side loading, loading at an angle, slider, proof testing, and system performance during magnet testing. Column stresses are itemized and measurements given.
Microplasma stamps for selective surface modification: design and characterization (2008)

Microplasma stamps are based upon the principle of dielectric barrier discharges. They are applied to a new type of area-selective surface modification process at atmospheric pressure. This process integrates the surface treatment and lateral microstructuring within one process step. For this purpose the plasma is ignited in cavities which are formed temporarily by compressing the microplasma stamp and the substrate to be treated. The advantage of the microplasma stamp designs described in this work is the use of polydimethylsiloxane (PDMS) as a dielectric barrier. Because of its flexibility, PDMS enables a good adjustment to varying surfaces and with it ensures completely closed cavities. In this work the design of two different microplasma stamps is presented. Both designs are characterized considering the influence of the aspect ratio on the ignition and breakdown voltage as well as the ignition under varying conditions. All experiments have been carried out at atmospheric pressure with medium frequency excitation (33 kHz). Furthermore the experimental results are verified by simulations using an SIPDP and FEM model.
Application of workplace correction factors to dosemeter results for the assessment of personal doses at nuclear facilities (2007)

Ratios of H(p)(10) and H*(10) were determined with reference instruments in a number of workplace fields within the nuclear industry and used to derive workplace-specific correction factors. When commercial survey meter results together with these factors were applied to the results of the locally used personal dosemeters their results improved and became within 0.7 and 1.7 of the reference values or better depending on the response of the survey meter. A similar result was obtained when a correction was determined with a prototype reference instrument for H(p)(10) after adjustment of its response. Commercially available survey instruments both for photon and neutron H*(10) measurements agreed with the reference instruments in most cases to within 0.5-1.5. Those conclusions are derived from results reported within the EC supported EVIDOS contract.
Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls (2009)

Melanoma risk at different body sites is associated with different amounts and patterns of sun exposure. Recreational sun exposure and sunburn are strong predictors of melanoma at all latitudes, whereas measures of occupational and total sun exposure appear to predict melanoma predominately at low latitudes.