gebhart/patrepeval huggingface dataset:
Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice (1995)

Sulfation represents a major pathway for the inactivation of steroid hormones such as estrogens and is catalyzed by a group of enzymes called sulfotransferases. Aberrant regulation of an estrogen sulfotransferase has been demonstrated previously in the livers of obese and diabetogenic C57BL/KsJ-db/db strain mice. In this paper, we report the molecular cloning and functional characterization of a full-length complementary DNA for estrogen sulfotransferase from mouse testis. The mouse estrogen sulfotransferase complementary DNA encodes 295 amino acids. It shares 88%, 77%, 75%, and 68% identity in amino acid sequence with the rat liver, human liver, guinea pig adrenal, and bovine placental estrogen sulfotransferase, respectively. The mouse enzyme was expressed as a glutathione-S-transferase fusion protein in Escherichia coli. The fusion protein was affinity purified, and milligram quantities of pure enzyme were obtained after cleavage of the fusion protein with thrombin. The expressed enzyme exhibits a high substrate specificity toward estrogens, including estradiol and estrone. Neither dehydroepiandrosterone, pregnenolone, testosterone, nor a simple phenolic compound, 4-nitrophenol appears to be a substrate. Northern hybridization indicates that messenger RNA (1.3 kilobases) for the estrogen sulfotransferase is expressed exclusively in the testes in control C57BL/KsJ mice. However, both the messenger RNA and protein are dramatically induced in the livers of obese and diabetogenic C57BL/KsJ-db/db mice. In contrast to the liver, the constitutive expression of the enzyme in the testis is not affected by the db/db genotype. These results recapitulate the species-specific nature in the tissue distribution of estrogen sulfotransferase and suggest complex regulatory mechanisms in its expression under normal and pathophysiological conditions.
Hole photogeneration in polycrystalline films of triphenylamine (1978)

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The influence of fixation peg design on the shear stability of prosthetic implants (1990)

The variety of fixation peg designs existing on prosthetic implants indicates uncertainty regarding the optimum design of fixation pegs for the reduction of stress and relative motion at the bone-implant interface. Fixation pegs have a number of important functions on a prosthesis, one of which is to reduce shear stress and shear displacement at the bone-implant interface. This is a parametric study intended to identify trends in the shear stability of prostheses incorporating a range of fixation peg designs. The parameters varied included the number of fixation pegs on a surface, the size of the pegs, and the aspect ratio (length/diameter) of the pegs. Mechanical tests were performed on urethane foam blocks with mechanical properties comparable to trabecular bone. The results indicated the following: (a) Fixation pegs act independently in resisting shearing force if they are spaced sufficiently far apart. (b) For any given shear displacement, smaller pegs generate a greater resistive shear force per unit of peg projected area in the direction of the applied load than larger pegs having the same aspect ratio. (c) Smaller diameter pegs cause the supporting material to yield at lower displacements. (d) Pegs with a high aspect ratio provide high shear stability with a minimum amount of bone removed, but may bend if the aspect ratio becomes excessive. (e) Smaller, slender pegs generate a greater resistive shear force at a given displacement per unit of peg volume than larger, lower aspect ratio pegs.(ABSTRACT TRUNCATED AT 250 WORDS)
Statistical Dialog Management Methodologies for Real Applications (2010)

In this paper we present a proposal for the development of dialog systems that, on the one hand, takes into account the benefits of using standards like VoiceXML, whilst on the other, includes a statistical dialog module to avoid the effort of manually defining the dialog strategy. This module is trained using a labeled dialog corpus, and selects the next system response considering a classification process that takes into account the dialog history. Thus, system developers only need to define a set of VoiceXML files, each including a system prompt and the associated grammar to recognize the users responses to the prompt. We have applied this technique to develop a dialog system in VoiceXML that provides railway information in Spanish. 1
SiGe technology: application to wireless digital communications (2002)

Heterojunction bipolar technology using SiGe epitaxial base grown by ultra high vacuum/chemical vapor deposition (UHV/CVD) offers very high performance and very low cost for the production of wireless communication high frequency ICs. This paper reports on the status of SiGe HBT development and compares it with existing Si and GaAs technologies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Routine sequencing in CLL has prognostic implications and provides new insight into pathogenesis and targeted treatments (2019)

Chronic lymphocytic leukaemia (CLL) is a genetically heterogeneous disease characterised by genomic alterations and gene mutations that may portend worse survival or resistance to treatments. A total of 680 blood or bone marrow samples underwent targeted sequencing of 29 genes previously identified as being mutated in CLL, which were correlated to known prognostic clinical characteristics. Overall, 400 (59%) patients were treatment-naïve (TN) and 280 (41%) were relapsed/refractory (R/R). Most patients (70%) had ≥1 mutation, with TP53 (22%), SF3B1 (18%), NOTCH1 (13%) and ATM (13%) being the most commonly mutated genes. A higher proportion of R/R patients had mutations in SF3B1 (P = 0·01) and TP53 (P < 0·001). Patients with mutated IGHV CLL more often had mutations in KLHL6 (P = 0·001) and MYD88 (P < 0·001). Pairwise associations showed mutational co-occurrences in the TN group including SF3B1/ATM [false discovery rate (FDR) < 0·05] and NOTCH1/POT1 (FDR < 0·01). Recurrent mutations resulting in premature truncation prior to the ubiquitination domains of NOTCH1 in its PEST domain and BIRC3 in its RING domain can produce proteins that constitutively activate CLL. Frequent missense mutations, such as K700E in SF3B1 and E571K in XPO1, have unknown function but are most likely to be activating mutations. Future directions include using these mutations to identify pathways for therapeutic targeting and rational drug design.
SOSTDC1 is down-regulated in non-small cell lung cancer and contributes to cancer cell proliferation (2016)

SOSTDC1 is down-regulated in NSCLC, and its expression level is indicative of clinical outcome of patients with the disease. SOSTDC1 might represent a tumor suppressor through inhibiting the proliferation of NSCLC cells by regulating p21Cip and p27Kip, which in turn affects Rb-E2F signaling.
Facile Fabrication of Durable Copper-Based Superhydrophobic Surfaces via Electrodeposition (2017)

Superhydrophobic surfaces have myriad industrial applications, yet their practical utilization has been limited by their poor mechanical durability and longevity. We present a low-cost, facile process to develop superhydrophobic copper-based coatings via an electrodeposition route, that addresses this limitation. Through electrodeposition, a stable, multiscale, cauliflower shaped fractal morphology was obtained and upon modification by stearic acid, the prepared coatings show extreme water repellency with contact angle of 162 ± 2° and roll-off angle of about 3°. Systematic studies are presented on coatings fabricated under different processing conditions to demonstrate good durability, mechanical and underwater stability, corrosion resistance, and self-cleaning effect. The study also presents an approach for rejuvenation of slippery superhydrophobic nature (roll-off angle <10°) on the surfaces after long-term water immersion. The presented process can be scaled to larger, durable coatings with controllable wettability for diverse applications.
Digitally controllable delay element using switched-current mirror (2009)

Abstract:-Controllable delay elements are essential for shifting the edges of signals in many digital and mixed-mode signal processing integrated circuits. Digitally programmable delay elements (DPDEs) are more flexible, less susceptible to noise and exhibit more robustness than their analog counterparts. In this paper, a partially programmable and a fully programmable delay elements are proposed. Together with a switched current mirror, a gate decoupling technique is applied to the former while a Schmitt type inverter is used in the later structure to achieve more significantly reduced static and short-circuit current. The delay elements are implemented in a 0.18um technology and simulation results with a 1V power supply show a more than 40 % power saving while operating at a speed of 450MHz in both structures.
Efficient Cell and Cell-Sheet Harvesting Based on Smart Surfaces Coated with a Multifunctional and Self-Organizing Elastin-Like Recombinamer (2013)

A wide range of smart surfaces with novel properties relevant for biomedical applications have been developed recently. Herein we focus on thermoresponsive surfaces that switch between cell-adherent and nonadherent states and their applications for cell harvesting. These smart surfaces are obtained by covalently coupling a tailored elastin-like recombinamer onto glass surfaces by means of the well-known and widely applied Click Chemistry methodology. The resulting recombinamer-functionalized surfaces have been characterized by means of water contact angle measurements, XPS and TOF-SIMS. A cell-based analysis of these surfaces with human fibroblasts showed a high degree of adhesion to the surface in its adherent state (37 °C), thus, promoting cell viability and proliferation. A temperature decrease triggers reorganization of the recombinamer, thus, markedly increasing the number of nonadherent domains and masking the adherent ones. This process allows a specific and efficient temporal control of cell adhesion and cell detachment. After determination of the properties required for a suitable cell-harvesting system, optimization of the process allows single cells or cell sheets from at least two types of cells (HFF-1 and ADSCs) to be rapidly harvested.
Luminescence of tartrate bridged dinuclear 2,2′-bipyridine platinum(ii) complexes: emission color controlled by intra- and inter-molecular interactions in the solid state (2017)

Novel dinuclear Pt<sup>II</sup> complexes with a chiral (l-) and an achiral (meso-) tartrate [{Pt<sup>II</sup>(bpy)}<sub>2</sub>(μ-x-tart)] (bpy: 2,2'-bipyridine; tartH<sub>2</sub><sup>2-</sup>: tartrate; x = l (1), meso (2)) and with a racemic (dl-) tartrate [{Pt<sup>II</sup>(bpy)}<sub>2</sub>(μ-d-tart)][{Pt<sup>II</sup>(bpy)}<sub>2</sub>(μ-l-tart)] (3) were synthesized, and the influence of their stereochemistry on their molecular and crystal structures affecting their luminescence was discussed. Effects of the dinuclearity on the structures and luminescence were revealed by comparison with those of a novel racemic mononuclear complex [Pt<sup>II</sup>(bpy)(d-tartH<sub>2</sub>)][Pt<sup>II</sup>(bpy)(l-tartH<sub>2</sub>)] (4). The X-ray crystallography showed the crystallization of 1 in two polymorphs, namely monoclinic 3[1·6H<sub>2</sub>O] (1α) and triclinic 2[1·6H<sub>2</sub>O] (1β), and those of other complexes in monoclinic hydrate crystals 2·12.5H<sub>2</sub>O, 3·4H<sub>2</sub>O, and 4·H<sub>2</sub>O. The chiral complexes in 1α, 1β, and 3·4H<sub>2</sub>O showed clamshell-like structures with Pt-Pt and π-π interactions, while the achiral complex in 2·12.5H<sub>2</sub>O displayed a twisted form without intramolecular interactions. The complexes in 1α were assembled in a right-handed helical arrangement through significant Pt-Pt interactions, and those in 1β and 3·4H<sub>2</sub>O were stacked in one-dimensional columns through significant and slight π-π interactions, respectively. The complex in 2·12.5H<sub>2</sub>O constructed an intermolecular dimer through Pt-Pt interactions with its adjacent complex. The crystal structure of 4·H<sub>2</sub>O displayed a three-dimensional network architecture through π-π interactions and hydrogen bonding. These crystals exhibited luminescence depending on their molecular and crystal structures (λ<sub>max</sub> nm = 535 (4·H<sub>2</sub>O), 569 (3·4H<sub>2</sub>O), 621 (2·12.5H<sub>2</sub>O), 649 (1β), and 656 (1α)). The formations of intermolecular dimers and clamshell-like structures through Pt-Pt interactions in 2·12.5H<sub>2</sub>O and in 3·4H<sub>2</sub>O, respectively, lead to red-shifts in emissions compared to 4·H<sub>2</sub>O, and further low-energy emissions of 1α and 1β were derived from the intermolecular Pt-Pt and π-π interactions, respectively.
Location of the gene for theta antigen in the mouse III. The position of Thy-1 relative to Lap-1 and Mpi-1 (1979)

The position of the Thy-1 (theta cell surface antigen) locus on chromosome 9 of the mouse was determined relative to the biochemical markers Lap-1 (leucine arylaminopeptidase) and Mpi-1 (mannosephosphate isomerase). Four-point backcrosses using both male and female heterozygotes showed that the order of these loci is Lap-1--Thy-1--Mpi-1. By observing the segregation of alleles at the Mod-1 (cytoplasmic malic enzyme) locus, which is known to lie distal to these three markers, it was possible to show that Lap-1 is at the centromeric end of this gene group. The overall map for this portion of chromosome 9 as determined by these crosses is: Lap-1--5--Thy-1--7--Mpi-1--14--Mod-1.
Laser Crystallization of Transparent AZO Films on Sapphire With High Electron Mobility for Photo-Application (2014)

Transparent and conductive alumina-doped ZnO (AZO) films were deposited on sapphire substrates at room temperature by room temperature pulsed laser deposition (PLD) and then followed by laser crystallization at 500K. As implied by the Multiphysics Simulation, X-ray diffraction spectra and morphological characterizations show grain growth and crystallinity enhancement during the crystallization process, resulting in less film internal imperfections. With lower internal defects, higher conductivity and transmittance were expected. Electrical and optical measurements show that the crystallization process dramatically improves the electron mobility and conductivity while the carrier concentration decreases, which in turn increases infrared transmittance. Under an optimal laser crystallization condition, AZO films with low resistivity of 9.90×10−4 Ω-cm and a high electron mobility of 79 cm2/Vs. UV-Vis-IR transmittance spectrum shows the laser crystallization significantly enhanced the AZO film transparency to 6000nm with over 60% transmittance. And the crystallized AZO film shows 36% higher transmittance than room temperature PLD deposited AZO film over 900–5000nm wavelength range.
A simplified method for the evaluation of antioxidants (1971)

Abstract A procedure is described for rapid evaluation of antioxidants. Dilute aqueous emulsions of an antioxidant, carotene and lipid were prepared in spectrometer tubes. The oxidative destruction of carotene in the emulsion was observed directly with a colorimeter. The antioxidants were then evaluated according to their effect on the rate of carotene decolorization.
Centromeric chromatin and its dynamics in plants (2015)

Centromeres are chromatin structures that are required for proper separation of chromosomes during mitosis and meiosis. The centromere is composed of centromeric DNA, often enriched in satellite repeats, and kinetochore complex proteins. To date, over 100 kinetochore components have been identified in various eukaryotes. Kinetochore assembly begins with incorporation of centromeric histone H3 variant CENH3 into centromeric nucleosomes. Protein components of the kinetochore are either present at centromeres throughout the cell cycle or localize to centromeres transiently, prior to attachment of microtubules to each kinetochore in prometaphase of mitotic cells. This is the case for the spindle assembly checkpoint (SAC) proteins in animal cells. The SAC complex ensures equal separation of chromosomes between daughter nuclei by preventing anaphase onset before metaphase is complete, i.e. the sister kinetochores of all chromosomes are attached to spindle fibers from opposite poles. In this review, we focus on the organization of centromeric DNA and the kinetochore assembly in plants. We summarize recent advances regarding loading of CENH3 into the centromere, and the subcellular localization and protein-protein interactions of Arabidopsis thaliana proteins involved in kinetochore assembly and function. We describe the transcriptional activity of corresponding genes based on in silico analysis of their promoters and cell cycle-dependent expression. Additionally, barley homologs of all selected A. thaliana proteins have been identified in silico, and their sequences and domain structures are presented.
An All-Polyamide Intercooler for Turbo-Charged Engines (2007)

&lt;div class="htmlview paragraph"&gt;An all-nylon intercooler for automotive applications has been shown to be possible. The heat rejecting element (cooling core) can be made employing the latest developments in plastic tubing, and the joining of the tanks to the tubes can be accomplished by advanced plastic welding techniques. The resultant part is similar in performance and environmentally robust compared to the aluminum parts made today. This paper will discuss assembly techniques and thermal performance, including test data and results.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Increasing the robustness of the design is the recent development of extrusion grade polyphthalamide plastic tubing. The feasibility of production has been enhanced by the commercialization of laser welding of plastics using diode lasers. Computer modelling of the heat exchange process shows that the thermal resistance of a thin plastic tube is not a major problem when compared to metal tube; it is the boundary layers between the tube material and the fluids which are the major components of the thermal resistance.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The advantages of a plastic Intercooler include the following: corrosion resistance; mechanical robustness (no fatigue failures); lighter weight and potential for lower cost. Metal intercoolers today are primarily aluminum alloys which contain special alloy to support the brazing process used in manufacture. Thin-walled metal alloys have potential to corrode very quickly and aluminum alloys suffer from a finite fatigue life. Most plastics do not corrode when exposed to the normal automotive environment: salt water, antifreeze and lubricants.&lt;/div&gt;
Gas geochemistry studies at the gas hydrate occurrence in the permafrost environment of Mallik (NWT, Canada) (2003)

We present real-time mud gas monitoring data as well as results of noble gas and isotope investigations from the Mallik 2002 Production Research Well Program, an international research project on Gas Hydrates in the Northwest Territories of Canada. The program participants include 8 partners; The Geological Survey of Canada (GSC), The Japan National Oil Corporation (JNOC), GeoForschungsZentrum Potsdam (GFZ), United States Geological Survey (USGS), United States Department of the Energy (USDOE), India Ministry of Petroleum and Natural Gas (MOPNG)/Gas Authority of India (GAIL) and the Chevron-BP-Burlington joint venture group.
Dynamic Hierarchical Search on the GPU (2015)

Presentation at Motion in Games, Paris, 2015.
Study of Automatic GPU Offloading Method from Various Language Applications (2020)

In recent years, utilization of heterogeneous hardware other than small core CPU such as GPU, FPGA or many core CPU is increasing. However, when using heterogeneous hardware, barriers of technical skills such as CUDA are high. Based on that, I have proposed environment-adaptive software that enables automatic conversion, configuration, and high performance operation of once written code, according to the hardware to be placed. However, the source language for offloading was mainly C/C++ language applications currently, and there was no research for common offloading for various language applications. In this paper, I study a common method for automatically offloading for various language applications not only in C language but also in Python and Java.
579: Effects of Imiquimod, a Toll-Like Receptor-7 Agonist, on Cell Proliferation and Cytokine Production in Bladder Cancer in Vitro and in Vivo (2005)

You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 8:00 am - 12:00 pm1 Apr 2005579: Effects of Imiquimod, a Toll-Like Receptor-7 Agonist, on Cell Proliferation and Cytokine Production in Bladder Cancer in Vitro and in Vivo Eric B. Smith, Hidekki Kawamoto, Xuecke You, Mathew Albert, and Douglas S. Scherr Eric B. SmithEric B. Smith More articles by this author , Hidekki KawamotoHidekki Kawamoto More articles by this author , Xuecke YouXuecke You More articles by this author , Mathew AlbertMathew Albert More articles by this author , and Douglas S. ScherrDouglas S. Scherr More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34819-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "579: Effects of Imiquimod, a Toll-Like Receptor-7 Agonist, on Cell Proliferation and Cytokine Production in Bladder Cancer in Vitro and in Vivo." The Journal of Urology, 173(4S), p. 158 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 158 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Eric B. Smith More articles by this author Hidekki Kawamoto More articles by this author Xuecke You More articles by this author Mathew Albert More articles by this author Douglas S. Scherr More articles by this author Expand All Advertisement PDF DownloadLoading ...
Sorption by Organic Substances. II. Effect of Functioinal Groups on Ammonia Sorption (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSorption by Organic Substances. II. Effect of Functioinal Groups on Ammonia SorptionA. C. Zettlemoyer, J. J. Chessick, and Amir ChandCite this: J. Phys. Chem. 1955, 59, 4, 375–378Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://pubs.acs.org/doi/10.1021/j150526a024https://doi.org/10.1021/j150526a024research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts