gebhart/patrepeval huggingface dataset:
“Occlusal consideration for fixed implant prosthesis in mandibular posterior region” (2016)

インプラント治療が補綴歯科臨床の場で必要不可欠となった今日においても，未だ「インプラント支持固定性補綴装置に付与すべき咬合様式」のガイドラインまたは明確な基準は示されていない．本ポジションペーパーにおいては，その推奨されるべき一定の基準を示し，臨床上の指針として提案することを目的とした．本稿では，典型的な欠損形態である下顎大臼歯部欠損にインプラント支持補綴装置を装着した場合を想定している．口腔インプラントを適用した治療に関して経験豊富なエキスパートパネルを，（公社）日本補綴歯科学会会員から選出し，臨床の現場における事象を検証した結果として得られた意見を集積し，パネル会議で検討した．その結果，補綴装置の形態，咬合接触点の位置と数，側方運動時の咬合接触の有無，歯根膜の変位量の考慮，補綴装置咬合面の材料等に関する知見が得られ，推奨される一定の基準が示された．しかしながら，上記内容は明確な根拠に支持されるものではなく，治療効果と術後経過に関する研究が不十分であり，今後さらなる知見の集積と検証のもとに，ガイドラインを策定すべきである．
Diadem: Prefetch-Based Traffic Shaping for Energy Saving in Wireless Networks (2011)

Energy efficiency is critical to wireless networks. Power Saving Mode (PSM) in 802.11 allows wireless devices to sleep periodically to save energy. To assist PSM for better performance, traffic shaping approaches have been leveraged to achieve longer sleep time. Existing traffic shaping solutions mostly delay the data transmission which, however, may fail to deliver data on time due to network dynamics. Instead of delay-based measures, we propose a prefetch-based traffic shaping strategy in this paper. For applications where data requests could be sent in advance (e.g., video streaming), the data is requested in batches, which enables the device to sleep during the rest of time. Our proposal Diadem (Data-in-advance energy-saving mechanism), is more reliable against network churns, and more confidently avoids packets' missing deadlines. Diadem works where the bandwidth monitor in delay-based solutions is absent, or multiple devices coexist in a wireless LAN. Moreover, Diadem introduces extra chances for improved power saving schemes, such as Suspend-to-RAM. Through simulations, we show that Diadem can help devices to sleep for more than 80% of the running time, while the probability to impact application performance is 50% lower in Diadem (with batch size of 4) than in the delay-based one. We also build a prototype application on a Set-Top Box platform showing the posed programming overhead for developers is acceptable.
Liver and kidney transplantation from non-heart beating donors: the Pittsburgh experience. (1995)

Nineteen liver and 51 kidney retrievals (one pediatric pair is considered as a single organ) were performed in 26 non–heart-beating donors (NHBD) over a 5.5-year period. Consent for liver procurement was not obtained in seven cases. Fifty-seven allografts (14 livers and 43 kidneys) were transplanted while the remainder (5 livers and 8 kidneys) were discarded because of macroscopic and/or microscopic findings. This report discusses the outcome in this series of liver and kidney allografts from NHBD.
Molecular Engineering on MoS2 Enables Large Interlayers and Unlocked Basal Planes for High‐Performance Aqueous Zn‐Ion Storage (2021)

Abstract Aqueous Zn‐storage behaviors of MoS 2 ‐based cathodes mainly rely on the ion‐(de)intercalation at edge sites but are limited by the inactive basal plane. Herein, an in‐situ molecular engineering strategy in terms of structure defects manufacturing and O‐doping is proposed for MoS 2 (designated as D‐MoS 2 ‐O) to unlock the inert basal plane, expand the interlayer spacing (from 6.2 to 9.6 Å), and produce abundant 1T‐phase. The tailored D‐MoS 2 ‐O with excellent hydrophilicity and high conductivity allows the 3D Zn 2+ transport along both the ab plane and c ‐axis, thus achieving the exceptional high rate capability. Zn 2+ diffusion through the basal plane is verified by DFT computations. As a proof of concept, the wearable quasi‐solid‐state rechargeable Zn battery employing the D‐MoS 2 ‐O cathode operates stably even under severe bending conditions, showing great application prospects. This work opens a new window for designing high‐performance layered cathode materials for aqueous Zn‐ion batteries.
Experimental Validation of Autodesk® 3ds Max® Design 2009 and Daysim 3.0 (2009)

This article compares daylight simulation results generated with two simulation programs, Autodesk® 3ds Max® Design 2009 (3ds Max Design) and Daysim 3.0 (Daysim), to indoor illuminance measurements in a sidelit space. The sidelit space was in a single location, but was configured with five fenestration and glazing options, and operated under a variety of sky conditions. The measurements form a set of ‘daylighting test cases’ that were recently developed to evaluate the simulation capabilities and limitations of different daylight simulation programs. Both 3ds Max Design and Daysim were given external direct and diffuse irradiances as simulation input, from which the programs predicted indoor illuminances on a grid of upward facing work plane sensors and downward facing ceiling sensors.3ds Max Design is based on Exposure™ technology, a lighting analysis module that includes a ‘shader’ of the Perez sky model and that uses the mental ray® raytracer for the global illumination calculation. Daysim also uses the Perez sky model and is based on the Radiance backward raytracer combined with a daylight coefficient approach. The comparison of both programs with measurements demonstrated that 3ds Max Design simulated indoor illuminances for the daylighting test cases with reliability comparable to Daysim. Most mean bias errors and root mean square errors were in the range of those reported in earlier validation studies: both programs succeeded in reproducing measurements for a sidelit space with and without a lightshelf. While 3ds Max Design consistently underestimated the incoming light flux going through a translucent panel, Daysim results were lower than measurements for the internal venetian blind test case. The results suggest that the accuracy of both programs is sufficient for typical daylighting design investigations of spaces with complexity comparable to the five daylighting test cases.
Automatic Kronecker Product Model Based Detection of Repeated Patterns in 2D Urban Images (2013)

Repeated patterns (such as windows, tiles, balconies and doors) are prominent and significant features in urban scenes. Therefore, detection of these repeated patterns becomes very important for city scene analysis. This paper attacks the problem of repeated patterns detection in a precise, efficient and automatic way, by combining traditional feature extraction followed by a Kronecker product low-rank modeling approach. Our method is tailored for 2D images of building facades. We have developed algorithms for automatic selection of a representative texture within facade images using vanishing points and Harris corners. After rectifying the input images, we describe novel algorithms that extract repeated patterns by using Kronecker product based modeling that is based on a solid theoretical foundation. Our approach is unique and has not ever been used for facade analysis. We have tested our algorithms in a large set of images.
ChemInform Abstract: A Convenient Procedure for Converting Organic Thiols into Ethyldithio Derivatives. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microbubbles for Medical Applications (2014)

Ultrasound contrast agent (UCA) suspensions contain encapsulated microbubbles with radii ranging from 1 to 10 micrometers. The bubbles oscillate to the driving ultrasound pulse generating harmonics of the driving ultrasound frequency. This feature allows for the discrimination of non-linear bubble echoes from linear tissue echoes facilitating the visualization and quantification of blood perfusion in organs. Targeting the microbubbles to specific receptors in the body has led to molecular imaging application with ultrasound and targeted drug delivery with drug-loaded microbubbles. Traditional UCA production methods offer high yield but poor control over the microbubble size and uniformity. Medical ultrasound transducers typically operate at a single frequency, therefore only a small selection of bubbles resonates to the driving ultrasound pulse. Here we discuss recent lab-on-a-chip based production and sorting methods that have been shown to produce highly monodisperse bubbles, thereby improving the sensitivity of contrast-enhanced ultrasound imaging and molecular imaging with microbubbles. Moreover, monodisperse UCA show great potential for targeted drug delivery by the well-controlled bubble response.
Millimeter Wave V2X Communications: Use Cases and Design Considerations of Beam Management (2018)

Sharing perception sensor information (e.g., camera, radar, and LIDAR) among vehicles in proximity using vehicle-to-everything (V2X) communications provides non-line-of-sight (NLOS) information about the surrounding environment, improving the safety and traffic efficiency of cooperative automated driving. However, such application requires high data rates on the order of 10s to 100s of Mbps (or 1 Gbps), which cannot be supported by the existing V2X communication technologies such as IEEE 802.11p-based dedicated short-range communication (DSRC) in 5.9 GHz band. Millimeter wave (mmWave) communication has the potential to meet the high data rate demand thanks to its wide bandwidth. In this paper, we introduce potential use cases of mmWave V2X communications. Also, we discuss technical challenges and design considerations for mmWave V2X beam management. Particularly, we elaborate on how we can utilize low-frequency communication (e.g., 5.9 GHz DSRC), onboard sensors mounted at vehicles and infrastructures, and DSRC messages (e.g., vehicle position, speed, acceleration, and path prediction) to facilitate mmWave V2X beam management.
Screening of cervical cytological samples using coherent optical processing Part 2 (1978)

This paper is Part 2 of a three-part sequence dealing with coherent optical signal processing methods for screening Pap smears. Part 2 is devoted to model analysis and evaluation. A mathematical cell model is established to develop the radial spatial frequency profiles of representative cells F(rho). The quantity rho(2)|F(rho)|(2) is shown to be most effective in bringing out normal/malignant cell transform differences. Photographic contrast and gamma play a major role in amplifying cell discriminant features and reducing the effects of the aperture contribution.
Stability and ionization-induced structural transitions of sodium chloride microclusters from Hartree-Fock calculations:Na2Cl2(+)andNa2Cl(+) (1986)

The equilibrium properties of ${\mathrm{Na}}_{2}$${\mathrm{Cl}}_{2}$ and ${\mathrm{Na}}_{2}$Cl in both the neutral and the singly ionized state are evaluated by the Hartree-Fock method in a pseudopotential approach. Specific attention is given to ionization processes, in relation to observations on the relative abundance of ${\mathrm{Na}}_{\mathrm{n}}$${\mathrm{Cl}}_{\mathrm{n}\mathrm{\ensuremath{-}}1}$${\mathrm{}}^{+}$ and ${\mathrm{Na}}_{\mathrm{n}}$${\mathrm{Cl}}_{\mathrm{n}}$${\mathrm{}}^{+}$ clusters in mass spectra. Ionization is shown to be followed in both systems by symmetry breaking, leading to an equilibrium linear structure for ${\mathrm{Na}}_{2}$${\mathrm{Cl}}^{+}$ and to a triangular shape for the ionized dimer. The latter is very weakly bound against dissociation into ${\mathrm{Na}}_{2}$${\mathrm{Cl}}^{+}$ and a chlorine atom. These results provide a natural explanation for mass spectroscopy data on clusters, showing that chlorine-deficient ionized aggregates are more frequently observed than stoichiometric ones, and are also in broad agreement with experimental data on dissociation energies, ionization potentials, and equilibrium structural parameters.
Enhancing the Activity of Aspartate Kinase for an Overproduction of L-lysine by Corynebacterium glutamicum (2016)

Background: As in all the bacteria investigated, lysine biosynthesis in Corynebacterium glutamicum starts from aspartate and aspartate kinase is the principal enzyme involved in the lysine biosynthesis metabolic pathway. In C. glutamicum, this enzyme was regarded as potential target for improved production of lysine. Here the increased production of lysine by deregulating aspartate kinase gene in wild type C. glutamicum ATCC 13032 was described. Materials and Methods: Key regulatory enzyme aspartate kinase of C. glutamicum was manipulated by performing site-directed mutagenesis. The region coding for regulatory $-subunit in the aspartate kinase (lys C) gene was mutated by replacing the codon TCC-GTC to deregulate it from feedback inhibition, which resulted in improved lysine production. Results: About 4.2 g LG 1 of more lysine yield was observed in the recombinant mutant compared to the wild type and the studies proved recombinants of C. glutamicum with feedback resistant aspartate kinase would be a potential option to increase the L-lysine production by biotechnological process. The mutant lysine producing strain reported in this investigation can be economical for industrial application. Conclusion: It was concluded that the metabolic engineering strategy reported here could serve as good concept for the development of microorganisms as capable cellular factories for the production of industrially important metabolites.
Dual modulation of neuron‐specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons (2019)

Direct neuronal reprogramming can be achieved using different approaches: by expressing neuronal transcription factors or microRNAs; and by knocking down neuronal repressive elements. However, there still exists a high variability in terms of the quality and maturity of the induced neurons obtained, depending on the reprogramming strategy employed. Here, we evaluate different long-term culture conditions and study the effect of expressing the neuronal-specific microRNAs, miR124 and miR9/9*, while reprogramming with forced expression of the transcription factors Ascl1, Brn2, and knockdown of the neuronal repressor REST. We show that the addition of microRNAs supports neuronal maturation in terms of gene and protein expression, as well as in terms of electrophysiological properties.
Sensitivity to Triazolam in the Elderly (1991)

Triazolam caused a greater degree of sedation and greater impairment of psychomotor performance in healthy elderly persons than in young persons who received the same dose. These effects resulted from reduced clearance and higher plasma concentrations of triazolam rather than from an increased intrinsic sensitivity to the drug. On the basis of these results, the dosage of triazolam for elderly persons should be reduced on average by 50 percent.
Chaos game representation of gene structure (1990)

This paper presents a new method for representing DNA sequences. It permits the representation and investigation of patterns in sequences, visually revealing previously unknown structures. Based on a technique from chaotic dynamics, the method produces a picture of a gene sequence which displays both local and global patterns. The pictures have a complex structure which varies depending on the sequence. The method is termed Chaos Game Representation (CGR). CGR raises a new set of questions about the structure of DNA sequences, and is a new tool for investigating gene structure.
Geochemical and Clay-Size Minerals Evidence for the Provenance of LQC Loess Deposits in the Central Shandong, Northern China (2018)

The identification of the Shandong loess provenance adjacent to the floodplain of the Yellow River external the Loess Plateau is very important for revealing the path of dust accumulation and paleoenvironment, which has aroused widespread concern. In this study, the clay-size(
ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization (2023)

The actin cytoskeleton is tightly controlled by RhoGTPases, actin binding-proteins and nucleation-promoting factors to perform fundamental cellular functions. We have previously shown that ERK3, an atypical MAPK, controls IL-8 production and chemotaxis (Bogueka et al., 2020). Here, we show in human cells that ERK3 directly acts as a guanine nucleotide exchange factor for CDC42 and phosphorylates the ARP3 subunit of the ARP2/3 complex at S418 to promote filopodia formation and actin polymerization, respectively. Consistently, depletion of ERK3 prevented both basal and EGF-dependent RAC1 and CDC42 activation, maintenance of F-actin content, filopodia formation, and epithelial cell migration. Further, ERK3 protein bound directly to the purified ARP2/3 complex and augmented polymerization of actin in vitro. ERK3 kinase activity was required for the formation of actin-rich protrusions in mammalian cells. These findings unveil a fundamentally unique pathway employed by cells to control actin-dependent cellular functions.
Subcellular and Cell-Cycle Expression Profiles of CDK-Inhibitors in Normal Differentiating Myeloid Cells (1999)

A central question in hematopoiesis is how cell-cycling behavior changes during the emergence of the differentiated state. To further understand what genetic regulators might couple proliferation status to differentiation, we studied the expression of the cell-cycle inhibitors p21 and p27 during the in vitro differentiation of normal CD34(+) blast cells along the myeloid lineage. We find p27 but not p21 to be expressed in freshly harvested resting CD34(+) cells. Thereafter, p21 levels peak concurrent with cellular proliferation and then decline in expression as cells undergo terminal differentiation. In contrast, p27 levels are fairly constant but the subcellular localization of p27 changes from nuclear expression to predominantly cytoplasmic expression and finally to perinuclear localization at progressive stages of differentiation. This report discusses the implications of these findings.
Fabrication and Characterization of an 8 × 8 Terahertz Photoconductive Antenna Array for Spatially Resolved Time Domain Spectroscopy and Imaging Applications (2021)

Terahertz (THz) technology is promising in several applications such as imaging, spectroscopy and communications. Among several methods in the generation and detection of THz waves, a THz time-domain system that is developed using photoconductive antennas (PCA) as emitter and detector presents several advantages such as simple alignment, low cost, high performance etc. In this work, we report the design, fabrication and characterization of a 2-D PCA array that is capable of detecting both the amplitude and phase of the THz pulse. The PCA array is fabricated using LT-GaAs and has 8 channels with 64 pixels ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$8 \times 8$ </tex-math></inline-formula> ). A novel approach using a spatial light modulator (SLM) to steer and focus the infrared probe beam towards pixels of the PCA array is presented. Each channel records the photocurrent generated by the THz signal (amplitude and phase) separately and frequencies up to 1.4 THz can be detected. Furthermore, the parameters such as directional time delay of the THz pulse, crosstalk between the channels etc., were characterized. Finally, we show that the proposed 2D PCA array design is flexible and can be used for accelerated THz spectral image acquisition.
Data from Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib (2023)

&lt;div&gt;Abstract&lt;p&gt;Strains within the genus &lt;i&gt;Salinospora&lt;/i&gt; have been shown to produce complex natural products having antibiotic and antiproliferative activities. The biochemical basis for the cytotoxic effects of salinosporamide A has been linked to its ability to inhibit the proteasome. Synthetically accessible salinosporamide A (ML858) was used to determine its biochemical and biological activities and to compare its effects with those of bortezomib. ML858 and bortezomib show time- and concentration-dependent inhibition of the proteasome &lt;i&gt;in vitro&lt;/i&gt;. However, unlike bortezomib, which is a reversible inhibitor, ML858 covalently binds to the proteasome, resulting in the irreversible inhibition of 20S proteasome activity. ML858 was equipotent to bortezomib in cell-based reporter stabilization assays, but due to intramolecular instability is less potent in long-term assays. ML858 failed to maintain levels of proteasome inhibition necessary to achieve efficacy in tumor models responsive to bortezomib. Our results show that ML858 and bortezomib exhibit different kinetic and pharmacologic profiles and suggest that additional characterization of ML858 is warranted before its therapeutic potential can be fully appreciated. [Mol Cancer Ther 2006;5(12):3052–61]&lt;/p&gt;&lt;/div&gt;
Influence of interchain forces and supermolecular structure on the drawing behavior of nylon 66 fibers in the presence of supercritical carbon dioxide (2004)

Abstract The drawing behavior and mechanical properties of as‐spun and highly oriented nylon 66 fibers drawn in supercritical carbon dioxide (SCCO 2 ) were investigated. Conditions including different temperatures, CO 2 pressures, and plasticizers with different polarity were systematically studied. Results indicate that CO 2 is an efficient plasticizer for as‐spun nylon 66 fibers as shown by decreases in the draw stress. In contrast, CO 2 shows only a slight influence on the drawability of highly oriented nylon 66 fiber. The effect of other plasticizers such as water, methanol, and ethanol on the drawability of nylon 66 fibers is very similar to that of CO 2 . Tenacity and modulus of one‐stage drawn fibers were less than 0.8 and 5.0 GPa, respectively. Fibers with the highest tenacity and modulus, 0.96/5.04 and 1.06/5.04 GPa, were obtained by two‐stage drawing in SCCO 2 from as‐spun and drawn nylon 66 fibers, respectively. The main reason for the extremely low draw ratios (&lt;6.0) of nylon 66 fibers was the presence of hydrogen bonds in the crystalline phase. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2282–2288, 2004
544. Some 1- and 2-halogenobenzimidazoles (1963)

D. Harrison, J. T. Ralph and A. C. B. Smith, J. Chem. Soc., 1963, 2930 DOI: 10.1039/JR9630002930
Learning based control compensation for multi-axis gimbal systems using inverse and forward dynamics (2021)

Unmanned aerospace vehicles usually carry sensors (i.e., electro-optical and/or infrared imaging cameras) as their primary payload. These sensors are used for image processing, target tracking, surveillance, mapping, and providing high-resolution imagery for environmental surveys. It is crucial to obtain a steady image in all these applications. This is typically accomplished by using multi-axis gimbal systems. This paper concentrates on the modeling and control of a multi-axis gimbal system. A novel and fully outlined procedure is proposed to derive the nonlinear and highly coupled Equations of Motion of the two-axis gimbal system. Different from the existing literature, Forward Dynamics of the two-axis gimbal system is modeled using multi-body dynamics modeling techniques. In addition to the Forward Dynamics model, the Inverse Dynamics model is developed to estimate the complementary torques associated with the state and mechanism-dependent, complex disturbances acting on the system. A disturbance compensator based on multilayer perceptron (MLP) structure is implemented to cope with external and internal disturbances and parameter uncertainties through the torque input channel. Our initial simulations and experimental work show that the new NN (neural network)-based controller is performs better in the full operational range without requiring any tuning or adjustment when compared with well-known controllers such as cascaded PID, ADRC (Active Disturbance Rejection Control), Inverse Dynamics based controllers.