gebhart/patrepeval huggingface dataset:
IBRUTINIB WITH RITUXIMAB (IR) AND SHORT COURSE R‐HYPERCVAD/MTX IS VERY EFFICACIOUS IN PREVIOUSLY UNTREATED YOUNG PTS WITH MANTLE CELL LYMPHOMA (MCL) (2019)

Introduction: Ibrutinib with rituximab (IR) combination induces durable responses in relapsed MCL. This is a single institution phase II trial of IR with short course (4 cycles) of R-HCVAD/R-MTX consolidation as frontline therapy in MCL. Methods: Previously untreated young (≤65 years) MCL pts (n=50) were included. The study was registered with a ClinicalTrials.gov identifier number NCT02427620. Pts received IR induction (part-A), until they achieved complete remission (CR) up to a maximum of 12 cycles, followed by only 4 cycles of R-HCVAD/R-MTX (part-B). None of the patients received stem cell transplant or maintenance. The primary objective was to assess response rates after part-A. Among evaluable samples, minimal residual disease (MRD) by flow cytometry at best response, clonal evolution using circulating tumor DNA (ctDNA) at various time points, baseline somatic mutations and baseline gene expression profile (GEP) was performed. Results: Overall, the median follow up was 36 months (10-42). Forty nine percent had high Ki-67 (≥30%), 72% had low risk MIPI score, one pt had TP53 mutation and 2 pts had aggressive MCL (one blastoid and one pleomorphic). Median number of cycles on IR was 6 (2-12). Overall response (ORR) on part-A of therapy was 100% (90% CR and 10% PR) and at the time of last follow up after completion of part A and part B, ORR was 100% (All CR). MRD negative CR rate assessed by bone marrow flow cytometry performed at best response at any phase of treatment was 91%. Overall, the median PFS and OS were not reached (3 year 89% and 100% respectively). Four pts had progressed after 17, 24, 34, 35 months of treatment (3 pts had Ki-67% ≥ 30% and one was blastoid MCL). None of the pts died. Grade 3-4 toxicities on part A were 4% myelosuppression and 8% each with fatigue, myalgia and rashes. GEP was done in 18 pts (2 PR, 16 CR on part A). Pts in PR had higher expression of HES1while those in CR had significantly higher expression of CTLA4 and ITK genes compared to those in PR. Targeted DNA sequencing was done in 18 pts at baseline, one pt with PR had NSD2, KMT2C and another pt had TP53 mutations and had CR. Keywords: hyper-CVAD; ibrutinib; mantle cell lymphoma (MCL). Disclosures: Wang, M: Consultant Advisory Role: Janssen, AstraZeneca, MoreHealth, Pulse Biosciences, AxImmune, Celgene, Juno Therapeutics, Pharmacyclics, IO Biotech, BioInvent; Stock Ownership: MoreHealth; Honoraria: Janssen, Dava Oncology, OMI, PeerView Institute for Medical Education (PVI); Research Funding: Janssen, AstraZeneca, Acerta Pharma, Juno Therapeutics, Kite Pharma, BeiGene, Novartis, Celgene, BioInvent, Karus, Oncternal, Amgen.
Percutaneous Transcatheter Recanalization in the Management of Acute Renal Failure due to Sudden Occlusion of the Renal Artery to a Solitary Kidney (1987)

Percutaneous angioplasty was attempted in 5 patients with acute renal failure due to occlusion of the artery to a solitary functioning kidney. Angioplasty was technically successful in all patients. Renal function was completely restored in 3 and renal perfusion improved in 1 patient. In the fifth patient, renal function did not return despite ultrasound and radionuclide scan evidence of renal reperfusion. Transcatheter thrombolytic therapy was attempted in 2 patients, 1 of whom also underwent angioplasty. In this patient, perfusion was restored to most of the kidney. In the other patient an infrarenal aortic occlusion was present. During thrombolytic therapy, intrarenal microembolization occurred from lysis of the aortic thrombus, leading to irreversible renal damage.
Transient dynamics during stress overshoots in binary colloidal glasses (2014)

We investigate, using simultaneous rheology and confocal microscopy, the time-dependent stress response and transient single-particle dynamics following a step change in shear rate in binary colloidal glasses with large dynamical asymmetry and different mixing ratios. The transition from solid-like response to flow is characterised by a stress overshoot, whose magnitude is linked to transient superdiffusive dynamics as well as cage compression effects. These and the yield strain at which the overshoot occurs vary with the mixing ratio, and hence the prevailing caging mechanism. The yielding and stress storage are dominated by dynamics on different time and length scales, the short-time in-cage dynamics and the long-time structural relaxation respectively. These time scales and their relation to the characteristic time associated with the applied shear, namely the inverse shear rate, result in two different and distinct regimes of the shear rate dependencies of the yield strain and the magnitude of the stress overshoot.
Frontiers in ruminant nutrition: An ASAS-CSAS-WSASAS 2020 Symposium overview (2020)

Journal Article Frontiers in ruminant nutrition: An ASAS-CSAS-WSASAS 2020 Symposium overview Get access Joel S Caton, Joel S Caton Department of Animal Sciences, North Dakota State University, NDSU Dept., Fargo, ND, USA Corresponding author: joel.caton@ndsu.edu Search for other works by this author on: Oxford Academic PubMed Google Scholar Terry Engle, Terry Engle Animal Sciences, Colorado State University, Fort Collins, CO, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Matthew S Crouse, Matthew S Crouse USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA https://orcid.org/0000-0003-4579-2737 Search for other works by this author on: Oxford Academic PubMed Google Scholar Shawn Archibeque, Shawn Archibeque Animal Sciences, Colorado State University, Fort Collins, CO, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar T G Nagaraja, T G Nagaraja Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA https://orcid.org/0000-0002-0899-878X Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald Huntington Gerald Huntington Animal Science, North Carolina State University, Box 7621. Raleigh, NC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Animal Science, Volume 98, Issue 9, September 2020, skaa276, https://doi.org/10.1093/jas/skaa276 Published: 15 September 2020 Article history Received: 01 August 2020 Accepted: 23 August 2020 Corrected and typeset: 15 September 2020 Published: 15 September 2020
포스트모던 시대 영성적 교회에 대한 연구 -틸리히 교회론의 영성적 재구성 (2012)

새로운 영성의 추구가 높아지는 시대 속에서, 교회가 영적 본질을 제대로 드러내지 못하는 현실은 교회 쇠퇴의 원인 중 하나이다. 반면에 현대의 다양한 영성의 흐름 속에서, 교회가 영적 추구를 향해 갈 때 그 기준과 진정성의 식별이 모호한 현실 역시 교회가 직면하는 어려움이다. 이와 같은 시점에서 깊은 영성을 추구하면서도 분별력 있는 신학적 기준을 세울 수 있는 교회론이 절실하다. 더구나 포스트모던 시대는 모던적 사유의 이분법적이고 교리적이며 개념화된 방식을 넘어서는 통합적이고 관계적인 영성을 추구하고 있다. 본 글은 이러한 포스트모던 시대에 응답하는 교회의 방향을 ‘영성적교회론’ 으로 제시하고자 한다. 영성적 교회론은 영성과 공동체성을 담아 내며 교회의 왜곡에 대한 분명한 기준을 세울 수 있어야 한다. 이를 위해 틸리히의 교회론을 영성적 관점에서 재구성하고자 시도하였다. 틸리히의 ‘영 공동체 교회론’을 영성적 관점으로 새롭게 읽어보는 것은 그의 성령론과 교회론이 영성의 원형적 특징을 갖추고 있다고 보기 때문이다. 틸리히의 교회론의 재구성을 위한 영성적 관점은, 현대 영성연구에서 통합적 영성의 길을 신인세계관계구조의 측면에서 모색하고 양가적 원형의 차원에서 밝힌 김화영의 연구를 주로 참고하였다. 일반적으로 이해되고 있는 전통적 영성은 ‘합일’을 강조하고, 현대적 영성은 ‘임재’를 강조하지만, 이 두 유형은 각각의 한계를 갖는다. 그러나 틸리히는 영성을 통합적인 관계구조의 관점으로 보며, 영성의 원형적 양가성을 영적 성장의 중요한 개념으로 밝힌다. 이러한 영성의 양가성은 영성의 한쪽 측면만을 강조하여 왜곡되는 것을 분별할 수 있게 한다. 또한 종교개혁의 핵심인 ‘오직’과 하나님의 절대 자유와 주권을 양가적 원형을 회복하는 것으로 해석하여 종교개혁적 영성의 정체성을 규명하고 있다. 이러한 영성의 양가적 본질과 왜곡을 돌파하는 종교개혁적 원리는 틸리히의 교회론과 상응한다. ‘영 공동체’의 가장 기본적인 특성이자영적 현존의 핵심인 ‘황홀’은 영적 인간의 자기초월적인 상태를 표현한 것이다. 이때 ‘황홀’은 인간 영의 합리적 구조를 깨지 않는다. ‘황홀’의 양가성은 ‘황홀’이 합리적 구조를 잠식할 때 마성화로, 황홀이 합리적 구조에 의해 제도화되거나 교리화될 때 세속화로 나타난다. 틸리히는 ‘황홀과 합리적 구조의 일치’의 원리를 성령의 나타남과 그 경험, 즉 영성을 추구하는 교회들이 적용해야 하는 원리로서 제시하고 있다. 교회는 영 공동체를 영적 원형으로서 갖고 있으며 동시에 사회적 실재이므로 역설성과 함께 종교의 모호성을 드러낸다. 이때 이 모호성과 왜곡을 극복할 수 있는 원리 역시 영적 현존의 원리, 즉 성령의 자유의 원리이다. 이것은 개혁의 원리로 작용하는 ‘프로테스탄트 원리’로서, 모든 인간적인 것을 초월하는 하나님의 주권과 절대성을 드러낸다. 하나님의 영의 원리는 마성화와 세속화의 왜곡을 돌파하는 개혁의 원리이다. 이러한 기준은 영성을 추구하는 교회들에게 혼란스러운 영적 현상들을 분별할 수 있게 할 것이다. 또한 영적 본질을 왜곡하는 제도화와 교리화를 탈피하고 교회의 영적 현존을 드러내도록 촉구할 것이다. 본 논문은 틸리히의 교회론을 영성적 차원으로 재구성한 새로운 시도로서 의의를 가지며, 현실 교회의 삶에 실제적으로 적용할 수 있는 원리들을 제시하고 있다.
The MADlib Analytics Library or MAD Skills, the SQL (2012)

MADlib is a free, open source library of in-database analytic methods. It provides an evolving suite of SQL-based algorithms for machine learning, data mining and statistics that run at scale within a database engine, with no need for data import/export to other tools. The goal is for MADlib to eventually serve a role for scalable database systems that is similar to the CRAN library for R: a community repository of statistical methods, this time written with scale and parallelism in mind. In this paper we introduce the MADlib project, including the background that led to its beginnings, and the motivation for its open source nature. We provide an overview of the library's architecture and design patterns, and provide a description of various statistical methods in that context. We include performance and speedup results of a core design pattern from one of those methods over the Greenplum parallel DBMS on a modest-sized test cluster. We then report on two initial efforts at incorporating academic research into MADlib, which is one of the project's goals. MADlib is freely available at http://madlib.net, and the project is open for contributions of both new methods, and ports to additional database platforms.
Heterocalixarenes featuring the benzimidazol-2-one subunit. Synthesis and X-ray structural studies of solvent inclusions (1996)

The heterocalixarenes 4a,b and 5a–f have been synthesized. Compounds 4a,b and 5a–d were obtained by two-step fragment condensation from benzimidazol-2-one and 1,3-bis(bromornethyl)benzene building elements using blocking/deblocking, high dilution and template (Cs2CO3) techniques to give 4a/5a and 4b/5b in an approximate 1 : 2 or 1 : 3 ratio of the cyclo oligomers. The cleavage of the methyl ether groups of 5a and 5b yielded the tetraphenols 5e and 5f, respectively. The calix hosts 4a, 5a–c and 5f form crystalline inclusion compounds with organic solvent molecules. X-Ray crystal structures of the solvent inclusions 5a·methylene chloride (1 : 1), 5b·toluene·water (1 : 2 : l), Sc·acetone·methylene chloride (1 : 1 : 1) and 5f·toluene (1 : 3) have been studied. The molecular structures show a general trend of having enhanced calix-forming ability compared with conventional calix[8]arenes of the same ring size. The shape of the host molecules appear to be determined by the packing of the symmetry centres of related host molecules on either one of the benzimidazolone rings yielding basket-like hosts (5a–c) or on one of the phenol rings resulting in a chair-like host shape (5f), always exhibiting base-stacking characteristics between the aromatic planes concerned.
Comparison of methodologies and geostatistical approaches for diagenesis quantification (2009)

http://www.searchanddiscovery.com/author.shtml#d
In-Place Data Sliding Algorithms for Many-Core Architectures (2015)

In-place data manipulation is very desirable in many-core architectures with limited on-board memory. This paper deals with the in-place implementation of a class of primitives that perform data movements in one direction. We call these primitives Data Sliding (DS) algorithms. Notable among them are relational algebra primitives (such as select and unique), padding to insert empty elements in a data structure, and stream compaction to reduce memory requirements. Their in-place implementation in a bulk synchronous parallel model, such as GPUs, is specially challenging due to the difficulties in synchronizing threads executing on different compute units. Using a novel adjacent work-group synchronization technique, we propose two algorithmic schemes for regular and irregular DS algorithms. With a set of 5 benchmarks, we validate our approaches and compare them to the state-of-the-art implementations of these benchmarks. Our regular DS algorithms demonstrate up to 9.11x and 73.25x on NVIDIA and AMD GPUs, respectively, the throughput of their competitors. Our irregular DS algorithms outperform NVIDIA Thrust library by up to 3.24x on the three most recent generations of NVIDIA GPUs.
GUNSHOT WOUNDS OF THE URETER (1974)

LANKFORD, ROBERT M.D.; BLOCK, NORMAN L. M.D.; POLITANO, VICTOR A. M.D. Author Information
Flow Tube Kinetics Investigation of the Mechanism of Detection in the Sulfur Chemiluminescence Detector (1997)

Rate constants and their temperature dependencies were measured for the chemiluminescent reaction of ozone with the flame and furnace effluents of two commercially available sulfur detectors, the Sulfur Chemiluminescence detector (registered trademark of Sievers Instruments, Inc.) and the Chemiluminescent Sulfur Detector (registered trademark of Antek Instruments, Inc.). The absolute rate constants and activation energies agreed within experimental error with the well-established values for the SO + O(3) reaction in all detector configurations. When ozone was present in the reaction zone, the reaction of the furnace effluent with NO(2) also was in good agreement with the rate constant for the SO + NO(2) reaction. However, when ozone was not present in the reaction zone, little or no reaction occurred with NO(2). These results imply that an unknown sulfur species, X, is formed in the combustion zone and/or transfer line of the instrument and converted to SO upon reaction with ozone in the chemiluminescence detection cell. Based on our experimental results and known reaction rate constants, we can eliminate S(2), S(2)O, SO(2), S(2)O(2), HS, HSO, HSO(2), HOSO(2), and H(2)S as X. We hypothesize that X is S(3) formed in the association reaction of S atoms with S(2) within the transfer line.
Proteins and immunohistochemical markers of breast diseases (2020)

In this work, we have compared malignant and non-malignant diseases of the mammary gland using 8 proteins: HRG, MUC1, PAI-1, HSP90αA1, CDH1, ERα, PGR and IL-12. Their concentrations in the supernatants of blood cells and breast biopsies were compared in terms of spontaneous production, induced by a polyclonal activator and after exposure to biopsy samples of the HLDF differentiation factor, as well as the indices of the effect of the polyclonal activator and HLDF on the protein production. In addition, the correlation relationships of the above indicators with the expression of markers of the epithelial-mesenchymal transition: collagen type II (CII), β-1 integrin (CD29) and cadherin-E (CDH1) were studied. The study revealed statistically significant differences in the concentration of HRG in the supernatant of blood cells, IL-12 during spontaneous production by biopsy specimens, PGR production of biopsy specimens induced by the polyclonal activator, CDH1 and IL-12 production biopsy specimens exposed to HLDF. According to the influence index of the polyclonal activator and HLDF, statistically significant differences were found for CDH1production. Comparison of non-specific invasive carcinoma biopsy specimens and non-malignant breast diseases by means of the markers of the epithelial-mesenchymal transition revealed statistically significant differences in CD29 expression and the lack of differences in the expression of CDH1 and CII. This indicates the presence of cell atypia in samples of non-malignant breast diseases; it is confirmed by the recognized correlation between the production of certain proteins and the expression of the epithelial-mesenchymal transition markers.
ACOUSTICS OF KINEMATICALLY COMPLEX SHEAR FLOWS (2001)

A new nonasymptotic method is presented that reveals an unexpected richness in the spectrum of acoustic fluctuations in a shear flow with nontrivial (kinematically complex) mean kinematics. The usefulness of the method is illustrated by analysing three different specific cases of compressible hydrodynamic shear flows. The temporal evolution of perturbations spans a wide range of nonexponential behavior from shear-modified oscillations, transitions between oscillatory and nonperiodic (vortical) modes of motion to monotonic growth. The principal characteristic of the revealed acoustic phenomena is their asymptotic persistence. Exotic regimes like "Echoing" as well as unstable (including parametrically driven) solutions are identified. Further areas of application, for both the method and the new physics, are outlined.
Pacific Northwest Laboratory quarterly report to ERDA Nuclear Research and Applications Division, January--March 1976. [Use of /sup 90/SrF/sub 2/ and /sup 137/CsCl WESF capsules as heat sources] (1976)

Progress in the strontium heat source and beneficial isotopes utilization programs is discussed. The couples required for the long-term tests compatibility were fabricated and the tests are under way. The 1000-hr tests were completed, and examination of the test couples has been started. Compatibility testing of two full-scale WESF /sup 90/SrF/sub 2/ capsules at 800/sup 0/C has started. Additional short-term compatibility testing of 25 potential containment materials are also under way. The 5000-hr aging tests of Hastelloy C-4 were completed and the specimens are being examined. Conceptual flowsheets were drawn up for recovery of various combinations of radioisotopes from stored high level wastes, and rough cost estimates were made. Additional calculations of /sup 137/CsCl capsule irradiation efficiency are reported. Conclusions of a study of the beneficial utilization of WESF /sup 90/SrF/sub 2/ capsules are presented.
Optochemical HCl Gas Detection Based on Tetraphenylporphine Dispersed in Ethyl Cellulose (1995)

Abstract To detect sub-ppm levels of dry HCl gas, spectral changes of tetraphenylporphine dispersed in ethylcellulose were examined in the visible region. The Soret and Q-bands of free base tetraphenylporphine are sensitive to sub-ppm levels of HCl with a good reversibility and insensitive to NH3, Cl2, NO2 and NO at room temperature.
Table ronde avec la participation de viticulteurs et d'experts. Video youtube https://www.youtube.com/watch?v=RhwUT6hE86g (2023)

communication orale, video youtube
Decomposition of Dithiocarbamates. V. The Dissociations of N-Monosubstituted Dithiocarbamic Acids in strongly Acidic and Alkaline Solutions (1973)

The dissociations of five N-monosubstituted dithiocarbamic acids (I) in strongly acidic and alkaline solutions were investigated spectrophotometrically. The existence following equilibrium, _??_(eq. 6) was established. The values of dissociation constants were determined. The Brønsted correlations between pK'Ior pK'III and pKa of corresponding amines (pKN) were found; pK'I or pK'III 0.48 pKN+α(α=-9.06 for pK'I;eq. 7, and α=12.43 for pK'III;eq.8).
Identification and quantification of diesel fuel components derived from off‐shore drilling operation discharges (1985)

Abstract A GC/MS technique that provides quantitative and qualitative information on diesel fuel components in drilling muds is described. Several low molecular mass aromatic components of diesel fuel are identified as indicators of diesel fuel. The presence and relative concentration of these indicators is used to identify diesel fuel contamination. This information can be used to approximate the amount of diesel fuel contamination in off‐shore drilling discharges.
Optimal Control of Seismic Structures (1986)

This paper presents the algorithm for optimal design of structural systems with active tendon controllers and/or active mass dampers. The structure is subjected to earthquake excitation modelled as a stationary random process. Using the approach one may economically resize structural members and effectively determine the optimal level of the control forces and control parameters.
Hydrogen-Bonding Effects on the Properties of Phenoxyl Radicals. An EPR, Kinetic, and Computational Study (2003)

The effect of 1,1,1,3,3,3-hexafluoropropan-2-ol (HFP) on the properties of phenoxyl radicals has been investigated. HFP produces large variations of the phenoxyl hyperfine splitting constants indicative of a large redistribution of electron spin density, which can be accounted for by the increased importance of the mesomeric structures with electric charge separation. The conformational rigidity of phenoxyl radicals with electron-releasing substituents is also greatly enhanced in the presence of HFP, as demonstrated by the 2 kcal/mol increase in the activation energy for the internal rotation of the p-OMe group in the p-methoxyphenoxyl radical. By using the EPR equilibration technique, we have found that in phenols the O-H bond dissociation enthalpy (BDE) is lowered in the presence of HFP because it preferentially stabilizes the phenoxyl radical. In phenols containing groups such as OR that are acceptors of H-bonds, the interaction between HFP and the substituent is stronger in the phenol than in the corresponding phenoxyl radical because the radical oxygen behaves as an electron-withdrawing group, which decreases the complexating ability of the substituent. In phenols containing OH or NH(2) groups, EPR experiments performed in H-bond accepting solvents showed that the interaction between the solvent and the substituent is much stronger in the phenoxyl radical than in the parent phenol because of the electron-withdrawing effect of the radical oxygen, which makes more acidic, and therefore more available to give H-bonds, the OH or NH(2) groups. These experimental results have been confirmed by DFT calculations. The effect of HFP solvent on the reactivity of phenols toward alkyl radicals has also been investigated. The results indicated that the decrease of BDE observed in the presence of HFP is not accompanied by a larger reactivity. The origin of this unexpected behavior has been shown by DFT computations. Finally, a remarkable increase in the persistency of the alpha-tocopheroxyl radical has been observed in the presence of HFP.
Six-Vertex Hydrogen-Rich Cp2M2B4H8 Dimetallaboranes of the Second- and Third-Row Transition Metals: Effects of Skeletal Electron Count on Preferred Polyhedra (2014)

The complete series of hydrogen-rich six-vertex cyclopentadienyl dimetallaboranes Cp2M2B4H8 (Cp = η5-C5H5; M = Ir, Ru/Os, Re, Mo/W, and Ta), including the experimentally known Ir, Ru, and Re derivatives synthesized by Fehlner and co-workers, have now been examined by density functional theory. The nature of the central M2B4 polyhedra in the lowest energy Cp2M2B4H8 structures relates to the skeletal electron count as determined by the Wade–Mingos rules. Thus, the lowest energy Cp2Ir2B4H8 structures with 16 Wadean skeletal electrons have central pentagonal-pyramidal Ir2B4 units similar to that of the known pentagonal-pyramidal B6H10. The lowest energy Cp2M2B4H8 (M = Ru, Os) structures with 14 Wadean skeletal electrons have central capped-tetragonal-pyramidal rather than octahedral M2B4 units. However, isomeric Cp2M2B4H8 (M = Ru, Os) structures with central M2B4 octahedra are found at energies starting at ∼15 kcal/mol (M = Ru) and ∼10 kcal/mol (M = Os) above the capped-tetragonal-pyramidal global minima. The lowest energy electron poorer Cp2M2B4H8 structures (M = Re, Mo, W, Ta) have central M2B4 bicapped tetrahedra with the metal atoms at the degree 5 vertices. Higher energy Cp2Re2B4H8 structures include capped-tetragonal-pyramidal structures with surface Re═Re double bonds and a pentagonal-pyramidal structure with a surface Re≡Re triple bond. The lowest energy Cp2M2B4H8 (M = Mo, W) structures appear to have surface M═M double bonds and thus also the 12 skeletal electrons for their bicapped-tetrahedral structures. However, the lowest energy likewise bicapped-tetrahedral Cp2Ta2B4H8 structure is best interpreted in having CpTa units with 16-electron rather than 18-electron tantalum configurations and a surface Ta–Ta single bond.