gebhart/patrepeval huggingface dataset:
Remote Sensing for Bio-Aerosol Detection. (2015)

Abstract not provided.
TaqMan-Based Detection of Trichomonas vaginalis DNA from Female Genital Specimens (2001)

A double-labeled fluorescent probe was designed and evaluated for detecting Trichomonas vaginalis DNA in a 5' nuclease (TaqMan) assay. The T. vaginalis-specific probe contains a 5'-fluorescein (5'-FAM) and a 3'-rhodamine (TAMRA) derivative. Female genital secretions were collected on Amplicor (Roche Molecular, Indianapolis, Ind.) swabs and by a transport system used for Chlamydia trachomatis and/or Neisseria gonorrhoeae DNA detection by PCR. Five hundred fifty-two female genital specimens, of which 248 (45%) were vaginal specimens and 304 (55%) were introital, were tested for both T. vaginalis DNA and viable microorganisms using the 5' nuclease assay and broth culture, respectively. Of these, 304 of 552 (55%) were also evaluated by direct microscopic examination for the characteristic motile organism. After resolving discrepancies, the comparisons produced an analytical sensitivity and specificity for the TaqMan-based PCR assay of 97.8 and 97.4%, respectively. As a result, DeltaRQ values (differences in fluorescence due to probe hybridization and resulting 5'-FAM cleavage from the specific PCR product) of > or =2.0 and < or =1.5 were established for T. vaginalis-positive and -negative cutoffs, respectively. DeltaRQ values between 1.5 and 2.0 were considered indeterminate. Overall findings revealed a high level of agreement between PCR and culture for detecting T. vaginalis. Potential benefits of the 5' nuclease assay include a greater sensitivity compared to direct microscopic examination and the ease of testing large numbers of clinical specimens in a significantly shorter turnaround time compared to culture.
Synapsin I, Synapsin II, and Synaptophysin: Marker Proteins of Synaptic Vesicles (1993)

The nerve terminal of neurons is filled with small synaptic vesicles, specialized secretory organelles involved in the storage and release of neurotransmitters. The synapsins are a family of four proteins that are the major peripheral proteins on the cytoplasmic face of synaptic vesicles. Synaptophysin is the major integral membrane protein of synaptic vesicles. The characterization of the synapsins and of synaptophysin during the last years has revealed exciting information about their structure, regulation and possible function. To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter.
Estudio de las propiedades de espín metalicidad en compuestos tipo A 2 FeMoO 6 , con A=Ba, Ca (2006)

Se estudian las propiedades electronicas y estructurales en los compuestos A 2 FeMoO 6 (A=Ba, Ca), a traves de calculos de densidades de estados con polarizacion de espin obtenidas con metodos de primeros principios. Como resultado, se aprecia la propiedad de espin-metalicidad en los dos compuestos. Ademas, empleando las densidades de estados parciales es posible inferir el mecanismo de conduccion en este tipo de compuestos, fundamentado en el modelo de Sarma.
AMP-activated Protein Kinase Phosphorylates Golgi-specific Brefeldin A ResistanceFactor 1 at Thr 1337 to Induce (2008)

Sufficiency and depletion of nutrients regulate the cellular activities through the protein phosphorylation reaction; how- ever, many protein substrates remain to be clarified. GBF1 (Golgi-specific brefeldin A resistance factor 1), a guanine nucle- otide exchange factor for the ADP-ribosylation factor family associated with the Golgi apparatus, was isolated as a phospho- protein from the glucose-depleted cells by using the phospho- Akt-substrate antibody, which recognizes the substrate proteins of several protein kinases. The phosphorylation of GBF1 was induced by 2-deoxyglucose (2-DG), which blocks glucose utili- zation and increases the intracellular AMP concentration, and by AICAR, an AMP-activated protein kinase (AMPK) activator. This phosphorylation was observed in the cells expressing the constitutively active AMPK. The 2-DG-induced phosphoryla- tion of GBF1 was suppressed by Compound C, an AMPK inhib- itor, and by the overexpression of the kinase-negative AMPK. Analysis using the deletion and point mutants identified Thr 1337 as the 2-DG-induced phosphorylation site in GBF1, which is phosphorylated by AMPK in vitro. ATP depletion is known to provoke the Golgi apparatus disassembly. Immunofluorescent microscopic analysis with the Golgi markers indicated that GBF1 associates with the fragmented Golgi apparatus in the cells treated with 2-DG and AICAR. The expression of the kinase-negative AMPK and the GBF1 mutant replacing Thr 1337 by Ala prevented the 2-DG-induced Golgi disassembly. These results indicate that GBF1 is a novel AMPK substrate and that the AMPK-mediated phosphorylation of GBF1 at Thr 1337 has a
Statistical model of a signal of Raman spectroscopy: Detection (2013)

Raman spectroscopy (RS) is a technique to find the spectral fingerprint of a material under study. To reach the spectrum, it is necessary to pass the acquired signal at the spectrometer by a bank of filters known as Raman signal's preprocessing system, which should eliminate all noise components accompanying the signal. The behavior of these noise components, and even the signal itself, are information that can be useful in order to optimize the system and to study the signal itself. This paper proposes a statistical model of Raman signal as the pre-processing system receives it, the signal's noise components and their statistical behavior, including its mathematical representation are presented. Additionally, it shows the results of the implementation of the simulation model leaving the door open for the validation, on which work is being done. The implementation of this model may be useful as an input signal for the optimization of the filter banks, since there are not always sufficient Raman signals for detailed study and development of filters for a specific signal under study. The model could also be used as a base for the study for systems using Raman spectroscopy to recognize substances.
Montelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation (2004)

Combined antihistamine and antileukotriene treatment started 6 weeks before the pollen season is effective in preventing AR symptoms and reduces allergic inflammation in nasal mucosa during natural allergen exposure.
Overview: PAF Receptor Antagonists: Recent Advances (1992)

(1992). Overview: PAF Receptor Antagonists: Recent Advances. Current Opinion on Therapeutic Patents: Vol. 2, No. 5, pp. 583-623.
Enhancing Osteogenic Differentiation of MC3T3-E1 Cells by Immobilizing Inorganic Polyphosphate onto Hyaluronic Acid Hydrogel (2014)

In tissue engineering, precise control of cues in the microenvironment is essential to stimulate cells to undergo bioactivities such as proliferation, differentiation, and matrix production. However, current approaches are inefficient in providing nondepleting cues. In this study, we have developed a novel bioactive hydrogel (HAX-PolyP) capable of enhancing tissue growth by conjugating inorganic polyphosphate chains onto hyaluronic acid macromers. The immobilized polyphosphates provided constant osteoconductive stimulation to the embedded murine osteoblast precursor cells, resulting in up-regulation of osteogenic marker genes and enhanced levels of ALP activity. The osteoconductive activity was significantly higher when compared to those stimulated with free-floating polyphosphates. Even at very low concentrations, immobilization of polyphosphates onto the scaffold allowed sufficient signaling leading to more effective osteoconduction. These results demonstrate the potential of our novel material as an injectable bioactive scaffold, which can be clinically useful for developing bone grafts and bone regeneration applications.
A Real-Time Approach to Modeling Soft Tissue Deformation (2001)

Abstract We are working toward developing a physically accurate real-time abdominal palpation simulator. To achieve this, two major goals must be met. The first is to develop a model that accurately simulates the physical characteristics of the tissues in the human abdomen. The model must not only be physically accurate, it must run in real-time for the simulation to be usable. The second major goal is to design a framework within which to parameterize physical properties of different tissues as well as a methodology to extract those parameters non-invasively.
Effect of Super Acid and Heteropolyacid on Residue Hydroprocessing (2015)

Production of highly branched aromatics and saturates from conversion of vacuum residue is of interest for production of high octane gasoline, gasoil, jet fuels and lubricants. In this study vacuum residue is hydroprocessed with superacid and hetropolyacid based catalysts at severe reaction conditions: 400-440pC reaction temperature, 100 bar of hydrogen pressure, 4-8 hours of reaction run time. A moderate conversion level, over 85% achieved with Mo-superacid at given reaction conditions. Upto 90% residue conversion and hydrotreating activities like HDM, HDS and HDAsp observed with Mo based heteropolyacid. Mo based acid catalysts have superiority over W based catalysts. Product distribution indicated that most part of liquid yield contain gasoil than gasoline.
Debugging at Full Speed (2014)

Debugging support for highly optimized execution environments is notoriously difficult to implement. The Truffle/Graal platform for implementing dynamic languages offers an opportunity to resolve the apparent trade-off between debugging and high performance.
Indoor Air Flow and Pollutant Removal in a Room with Task Ventilation (1991)

We studied the performance of a task ventilation system that permits occupants to control the flow rate and direction of air supplied to their work space through four floor-mounted supply grill. Air exited the room through a ceding-mounted return grill. To study air-flow patterns, we measured the age of air at multiple locations using a tracer gas stepup. To study the intra-room transport of tobacco smoke particles, cigarettes were smoked mechanically in one workstation and particle concentrations were measured at multiple locations. Our major findings were as follows: (1) deviations from uniform age of air, and uniform particle concentration, were generally less than 30 percent; (2)some supply air short-circuits to the return grill when directed toward the return with high velocity; (3) low supply velocities resulted in a floor-to-ceiling displacement flow; (4) directing the supply air toward the occupant, of partially toward the occupant, typically yielded an age of air at the occupant's breathing level that was 15 to 25 percent lower than the age at other breathing-level locations; (5) with low supply velocities und air directed toward the occupants, tobacco smoke particle concentrations in a ventilated non-smoking workstation were 50 percent of the chamber-average concentration.
HMGA1 and MMP-11 Are Overexpressed in Human Non-melanoma Skin Cancer (2018)

Our data confirm previous observations in mice studies, and suggest that HMGA1 and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans.
APPLICATION OF OFF-NADIR SATELLITE IMAGERY IN EARTHQUAKE DAMAGE ASSESSMENT USING OBJECT-BASED HOG FEATURE DESCRIPTOR (2019)

Abstract. One of the most crutial applications of very-high-resolution (VHR) satellite images is disaster management. In disaster management, time is of great importance. Therefore, it is vital to acquire satellite images as quickly as possible and benefit from automatic change detection to speed up the process. Automatic damage map generation is performed by overlaying the co-registered before and after images of the area of interest and, compring them to highlight the affected infrastructures. For speeding up image capture, satellites tilt their imaging sensor and take images from oblique angles. However, this kind of image acquisition causes severe geometric distortion in the images, which hinders image co-registration in automatic change detection. In this study, a Patch-Wise Co-Registration (PWCR) solution is used. In this algorithm, the before and after images are co-registered in a segment-by-segment manner. From the literature, this algorithm is followed by a spectral comparison to detect changes. However, due to the complicated structure of debris in damage detection applications, spectral comparison methods cannot perform well. In this work, we developed an object-based method using Histogram of Oriented Gradient descriptor to detect damges and compared our results to different existing spectral and textural change detection methods. The algorithm is tested on images from the 2010-Heidi earthquake, captured by DigitalGlobe. The achieved highly accurate results demonstrate the potential of using off-nadir remote sensing images for automatic urban damage detection possibly in early response systems as it speeds up the damage map generation by providing flexibility to utilize images taken from different anlges.
Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft (2009)

Leucocyte function-associated antigen-1 (LFA-1) is known to be involved in immune reactions leading to allograft rejection. The role of deactivating LFA-1 in this context has not been investigated yet, although it is accepted that regulating LFA-1 activity is essential for T-cell function. Expressing LFA-1 locked in an active state in mice (LFA-1(d/d)) allowed us to investigate the in vivo function of LFA-1 deactivation for allograft rejection in a model of heterotopic cardiac transplantation. We provide in vivo evidence that regulating LFA-1 activity from an active to an inactive state controls antigen-specific priming and proliferation of T cells in response to allogeneic stimuli. Consequently, defective LFA-1 deactivation significantly prolonged cardiac allograft survival. Furthermore, reduced numbers of alloantigen-specific T cells and non-allo-specific innate immune cells within allografts of LFA-1(d/d) recipients indicate that expression of active LFA-1 impairs inflammatory responses involving all major leucocyte subpopulations. Taken together, our in vivo data suggest that LFA-1 deactivation is important for the formation of inflammatory lesions and rejection of cardiac allografts. Thus, the dynamic regulation of LFA-1 activity, rather than the mere presence of LFA-1, appears to contribute to the control of immune reactions inducing allogeneic transplant rejection.
Ribosomal DNA internal transcribed spacers to estimate the proportion of Pisolithus tinctorius and Eucalyptus globulus RNAs in ectomycorrhiza (1997)

International audience
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C?, -? and -? transgenic mice (2001)

To define the in vivo role of individual PKC isoforms in mouse skin carcinogenesis, we previously characterized FVB/n transgenic mice that over-expressed epitope-tagged PKC delta (T7-PKC delta) or PKC epsilon (T7-PKC epsilon) isoforms under the regulation of the human K14 promoter. In continuation of our prior PKC isoform specificity studies, we now report the generation of FVB/n transgenic mice with K14-regulated, epitope-tagged PKC alpha (T7-PKC alpha). T7-PKC alpha transgenic mice (line 115) express 8-fold more PKC alpha protein than wild-type mice. Using high-resolution immunogold cytochemistry, we determined that transgenic over-expression of T7-PKC alpha did not alter the subcellular localization of PKC alpha but that the density of PKC alpha staining increased. PKC alpha localized primarily to the cytoskeleton (tonofilaments, tight junctions) and cell membranes, with modest but definite nuclear labeling also identified. Also, PKC alpha over-expression did not alter the immunoreactive protein levels of other PKC isoforms (delta, epsilon, eta, zeta, mu) in the epidermis. Skin tumor-promotion susceptibility was compared among all 3 lines of T7-PKC transgenic mice (alpha, delta and epsilon). While T7-PKC alpha had no effect on skin tumor promotion by TPA, T7-PKC delta reduced papilloma burden by 76% compared to wild-type controls. T7-PKC epsilon further reduced papilloma burden to 93% compared to wild-type controls but still resulted in the development of squamous-cell carcinoma. To find potential mechanisms of PKC-associated differences in tumor promotion, the induction of known downstream effectors of tumor promotion, ornithine decarboxylase (ODC) activity and epidermal hyperplasia, was determined. Despite long-term papilloma inhibition in both PKC delta and PKC epsilon transgenic mice, the induction of ODC by TPA was not attenuated in PKC delta and epsilon mouse lines. Both PKC transgenic and wild-type mice exhibited sustained hyperplasia after repeated TPA treatments. However, TPA-induced epidermal hyperplasia in T7-PKC epsilon mice was significantly increased (52%) compared with T7-PKC alpha, T7-PKC delta and wild-type mice. TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice.
3 Bioassays of Prions (1999)

Prior to the experimental transmission of scrapie to goats inoculated with tissue extracts prepared from sheep with scrapie (Cuille and Chelle 1939), no experimental studies of the disease were possible. Despite the cumbersome bioassays in sheep and goats, some limited information was obtained. For example, the susceptibility of 24 different breeds of sheep was measured after subcutaneous inoculation with brain extract prepared from a sheep with scrapie (Gordon 1946). The resistance of the scrapie agent to inactivation by formalin and heat was also shown using bioassays performed in sheep (Pattison and Millson 1960). The first evidence for strains of prions accumulated with goats that presented with two different clinical syndromes (Pattison and Millson 1961b). One set of prion-infected goats was described as “drowsy” due to the lethargy manifest during the clinical phase of scrapie, and the other was called “hyper” because these animals were highly irritable and easily aroused. One of the most distinctive and remarkable features of slow infections, such as those caused by prions, is their prolonged incubation periods, during which the host is free of recognizable clinical dysfunction. The onset of clinical symptoms marks the end of the incubation period and the beginning of a relatively short, progressive course of illness that ends in death. Although prolonged incubation periods are a fascinating phenomenon, they have been the biggest impediment to prion research. Because animals remain healthy throughout the incubation period, investigators must wait until signs of clinical illness appear before assigning a positive score. In early studies...
Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42 (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Familial multiple sclerosis: volumetric assessment in clinically symptomatic and asymptomatic individuals (1999)

A genetic basis for clustering of multiple sclerosis (MS) cases, based on studies of MS families, has been proposed for decades. Few reports provide detailed neurological as well as neuroradiological findings on these patients. We report total T2-weighted intracranial lesion volumes on members of three familial MS cohorts: a mother and father with conjugal MS with one affected son and a neurologically normal son and daughter, one pair of monozygotic twin sisters with MS, and a female sibling pair with MS. We hypothesized that asymptomatic siblings in a family with two affected parents and another affected child might demonstrate clinically silent T2-weighted lesions; and that monozygotic twins with MS are more likely to express similar T2-weighted lesion volumes than non-twin sibling pairs. We found clinically silent lesions in unaffected children of the symptomatic parent couple, with a significant difference in total T2 lesion volume between these unaffected siblings and their parents, as well as their affected brother. In our other sibling pairs, T2 lesion volumes were similar between the twins and significantly different in the non-twin pair, despite similar levels of clinical functioning as determined by EDSS scoring. These results suggest that foci of demyelination might be expected in clinically normal offspring of parents with MS, possibly reflecting a genetic predisposition to subsequent development of MS.
Magnetic moment and reluctance network mixed method applied to transformer modeling (2005)

The aim of the study is to find a method to model electromagnetic devices which generate consequent magnetic leakage. Classical methods have proved to be efficient but time consuming. The method proposed in this paper is based on the magnetic moment method (MMM). An original methodology to obtain a simplified MMM model is described, adjusted with simple RNM model results. Besides the good accuracy, the simplicity of the model makes it possible to consider complicated studies with reasonable resolution times.
Atomic Layer Deposition and Lithium-ion Batteries: Studies on new materials and reactions for battery development (2017)

The increasing interest in both portable electronic devices and electric vehicles has given rise to a new wave of research into lithium-ion batteries. Lithium-ion batteries are the technology of choice for these applications, as they offer both high power and high energy densities. However, much research on this subject is still needed to answer the technology demands of future applications. For example, the safety concerns related to liquid electrolytes in the batteries of electric vehicles could be resolved by moving to all-solid-state batteries, which would not combust in the case of an accident. In addition, all-solid-state batteries could be manufactured into 3D structures, which would decrease the footprint area of the battery without sacrificing the amount of material. Thus, these structures would make even higher energy densities possible, which is important for example for laptops and cellphones. In addition, by combining smaller batteries with energy harvesters, such as solar cells, integrated autonomous devices could be realized.&#13;\n&#13;\nAtomic layer deposition, or ALD, is a thin film deposition method based on sequential, saturative reactions of gaseous precursors with a substrate surface. ALD generally produces highly pure films with very good thickness uniformity also in difficult, 3D substrates. Therefore, ALD should be well-suited for the deposition of Li-ion battery materials for future applications.&#13;\n&#13;\nThe deposition of lithium containing materials is a fairly new avenue for ALD, the first paper being published only in 2009. It has been found that the Li-ion often bends the basic rules of ALD with its high reactivity and mobility during film growth, resulting in both unexpected reactions and film stoichiometries.&#13;\n&#13;\nThis thesis provides a comprehensive review on the atomic layer deposition of lithium containing materials with a focus on the behavior of lithium in the growth process. In the experimental part, new ALD processes were developed for potential Li-ion battery materials LiF and AlF3. Both processes show reasonable ALD characteristics and produce pure films in proper deposition temperatures. In addition, conversion reactions taking place in ALD conditions were studied, and both LiF and Li3AlF6 were deposited using these reactions. The conversions were very clean, illustrated by the low impurity contents of the converted films. Lastly, the deposition of lithium containing ternary oxides was studied by heating atomic layer deposited film stacks in air. This ALD-solid state reaction -procedure resulted in pure, crystalline films of LiTaO3, LiNbO3 and Li2TiO3.