gebhart/patrepeval huggingface dataset:
Diagnostic histopathology of tumors (2013)

VOLUME 1: Introduction. Tumors of the Heart and Pericardium. Tumors of Blood Vessels and Lymphatics. Tumors of the Upper Respiratory Tract. Part A: Nose and Paranasal Sinuses. Part B: Larynx and Trachea. Tumors of the Lung and Pleura. Tumors of the Oral Cavity. Tumors of the Salivary Glands. Tumors of the Esophagus and Stomach. Tumors of the Small and Large Intestines (Including the Anal Region). Tumors of the Hepatobiliary System. Tumors of the Exocrine Pancreas. Tumors of the Urinary Tract. Tumors of the Female Genital Tract. Part A: Tumours of the Ovary. Part B: Tumours of the Fallopian Tubes and Broad Ligaments. Part C: Tumours of the Endometrium. Part D: Tumours of the Placenta. Part E: Tumours of Teh Myometrium. Part F: Tumours of the Cervix. Part G: Tumours of the Vagina. Part H: Tumours of the Vulva. Tumors and Tumorous Conditions of the Male Genital Tract. Part A: Tumours and Tumorous Conditions of the Prostate. Part B: Tumours and Tumourous Conditions of the Testis. Part C: Tumours and Tumorous Conditions of the Penis. Tumors of the Peritoneum. Tumors of the Breast VOLUME 2: Tumors of the Pituitary Gland. Tumors of the Thyroid and Parathyroid Glands. Tumors of the Adrenal Glands. Tumors of the Endocrine Pancreas. Tumors of the Lymphoreticular System (Including Thymus). Tumors of the Hemopoietic System. Tumors of the Skin. Soft Tissue Tumors. Tumors of the Osteoarticular System. Tumors of the Central Nervous System. Peripheral Neuroectodermal Tumors. Tumors of the Autonomic Nervous System (Including Paraganglia). Tumors of the Eye and Adnexae. Tumors of the Ear. Electron Microscopy in Tumor Diagnosis. Modern Techniques in Tumor Diagnosis Index
ChemInform Abstract: Synthesis of Aromatic Aldehydes by Laccase‐Mediator Assisted Oxidation. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Incremental Sigma-Delta Modulators for 3D-Imaging: System Architecture and Signal Processing (2006)

The design of a system for measuring the time-of-flight of a pulsed light beam for 3-D imaging with 2-4 ps resolution is described. An array of Spanks determines the arrival times of a single reflected photon measured by a coarse 10 ns clock period and a fine of about 14 bit accuracy. The designed circuit uses an incremental second order SigmaDelta modulator with a current and voltage feedback DAC on the integrators. The time-of-flight integrated circuit is for a 6.25 MHz pulsed laser and a 2-D 32 times 64 pixels SPAD array. The use of four time-to-digital converters enable obtaining 25 frame/s 3-D image with 23 m measurement range and 0.3 mm resolution.
FDL 60 — An Advanced Film Scanning System (1984)

The presentation of the FDL 60 film scanner in Montreux in early 1979 was a milestone in the development of modern telecine technology. This article describes in detail the FDL 60, which utilizes semiconductor CCD sensors to scan the film without interlace, and generates 60 fields/sec from 24 film frames via a digital frame store using component coding. With the same basic unit and different options, it is possible to perform many operations for both broadcast and post-production, using maintenance-free digital techniques.
Evaluation of the Quality of Life Associated with Zidovudine Treatment in Asymptomatic Human Immunodeficiency Virus Infection (1994)

For asymptomatic patients treated with 500 mg of zidovudine, a reduction in the quality of life due to severe side effects of therapy approximately equals the increase in the quality of life associated with a delay in the progression of HIV disease.
Endothelin-1 Induces Alveolar Epithelial–Mesenchymal Transition through Endothelin Type A Receptor–Mediated Production of TGF-β1 (2007)

Endothelin-1 (ET-1) is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but the cellular mechanisms underlying the role it plays in this disease are not well characterized. Epithelial-mesenchymal transition (EMT), which was recently demonstrated in alveolar epithelial cells (AEC), may play an important role in the pathogenesis of IPF and other forms of pulmonary fibrosis. Whether ET-1 contributes to the induction of EMT in AEC is unknown. The aims of this study were to evaluate AEC production of ET-1 and to determine if ET-1 induces EMT in AEC. We demonstrate that ET-1 is produced at physiologically relevant levels by primary AEC and is secreted preferentially toward the basolateral surface. We also demonstrate that AEC express high levels of endothelin type A receptors (ET-A) and, to a lesser extent, type B receptors (ET-B), suggesting autocrine or paracrine function for alveolar ET-1. In addition, ET-1 induces EMT through ET-A activation. Furthermore, TGF-beta1 synthesis is increased by ET-1, ET-1 induces Smad3 phosphorylation, and ET-1-induced EMT is attenuated by a TGF-beta1-neutralizing antibody. Thus, ET-1 is an important mediator of EMT in AEC, acting through ET-A-mediated TGF-beta1 production. These findings increase our basic understanding of the role of ET-1 in pulmonary fibrosis and suggest potential roles for AEC-derived ET-1 in the pathogenesis of other alveolar epithelial-mediated lung diseases.
Detection of Chromosomal Polysomy in Oral Leukoplakia, a Premalignant Lesion (1993)

Journal Article Detection of Chromosomal Polysomy in Oral Leukoplakia, a Premalignant Lesion Get access Jin S. Lee, Jin S. Lee Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston Correspondence to : Jin S. Lee, M.D., The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 80, Houston, TX 77030. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sun Y. Kim, Sun Y. Kim Department of Clinical Investigation, The University of Texas M. D. Anderson Cancer CenterHouston Search for other works by this author on: Oxford Academic PubMed Google Scholar Waun K. Hong, Waun K. Hong Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston Search for other works by this author on: Oxford Academic PubMed Google Scholar Scott M. Lippman, Scott M. Lippman Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston Search for other works by this author on: Oxford Academic PubMed Google Scholar Jae Y. Ro, Jae Y. Ro Department of Pathology, The University of Texas M. D. Anderson Cancer CenterHouston Search for other works by this author on: Oxford Academic PubMed Google Scholar Marion L. Gay, Marion L. Gay Department of Clinical Investigation, The University of Texas M. D. Anderson Cancer CenterHouston Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter N. Hittelman Walter N. Hittelman Department of Clinical Investigation, The University of Texas M. D. Anderson Cancer CenterHouston * See “Notes” section following “References.”. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 23, 1 December 1993, Pages 1951–1954, https://doi.org/10.1093/jnci/85.23.1951 Published: 01 December 1993 Article history Received: 26 April 1993 Revision received: 24 August 1993 Accepted: 01 September 1993 Published: 01 December 1993
Analysis and Optimization of Direct-Conversion Receivers With 25% Duty-Cycle Current-Driven Passive Mixers (2010)

The performance of zero-IF receivers with current-driven passive mixers driven by 25% duty-cycle quadrature clocks is studied and analyzed. It is shown that, in general, these receivers outperform the ones that utilize passive mixers with 50% duty-cycle clocks. The known problems in receivers with 50% duty-cycle mixers, such as having unequal high- and low-side conversion gains, unexpected IIP2 and IIP3 numbers, and IQ crosstalk, are significantly lowered due to the operating principles of the 25% duty-cycle passive mixer. It is revealed that with an intelligent sizing of the design parameters, the 25%-duty-cycle-mixer-based receiver is superior in terms of linearity, noise, and elimination of IQ crosstalk.
Investigation of the Skive Hobbing Process by Applying a Dexel-based Cutting Simulation (2015)

In this paper, a novel approach for cutting simulation of skive hobbing is presented. Skive hobbing is a process applied for finishing of already hardened gears. The process is characterized by varying tool engagements and very small chip thicknesses. The paper describes the process-modeling and the analysis of the workpiece-tool contact. For efficient modeling, a novel dexel-based method is presented for the description of a gear segment with discretized stock allowance. Characteristic of the method is an analytical description of the target workpiece contour which allows to describe points of the surface by Cartesian coordinates on the winding off. Dexel are oriented orthogonal to the surface of the final workpiece contour. The initial lengths of the dexel describe the stock allowance. By cutting these dexel with a tool, a time- and position-dependent prediction of material removal values, e.g. width of undeformed chip or undeformed chip thickness, is possible. Selected results are presented and interpreted.
Adipogenesis in a myeloid supporting bone marrow stromal cell line (1992)

The bone marrow stroma contains pre-adipocyte cells which are part of the hemopoietic microenvironment. Cloned stromal cell lines differ both in their ability to support myeloid and lymphoid development and in their ability to undergo adipocyte differentiation in vitro. These processes have been examined in the +/+2.4 murine stromal cell line and compared to other stromal and pre-adipocyte cell lines. In long-term cultures, the +/+2.4 stromal cells support myeloid cell growth, consistent with their expression of macrophage-colony stimulating factor mRNA. However, despite the presence of mRNA for the lymphoid supportive cytokines interleukins 6 and 7, +/+2.4 cells failed to support stromal cell dependent B lineage lymphoid cells in vitro, suggesting that these stromal cells exhibit only a myelopoietic support function. The +/+2.4 cells differentiate into adipocytes spontaneously when cultured in 10% fetal bovine serum. The process of adipogenesis can be accelerated by a number of agonists based on morphologic and gene marker criteria. Following induction with hydrocortisone, methylisobutylxanthine, indomethacin, and insulin in combination, a time dependent increase in the steady state mRNA and enzyme activity levels of the following adipocyte specific genes was observed: adipocyte P2, adipsin, CAAT/enhancer binding protein, and lipoprotein lipase. In contrast, adipogenesis was accompanied by a slight decrease in the signal intensity of the macrophage-colony stimulating factor mRNA level, similar to that which has been reported in other bone marrow stromal cell lines. These data demonstrate that although the lympho-hematopoietic support function of pre-adipocyte bone marrow stromal cell lines is heterogeneous, they share a common mechanism of adipogenesis.
The ODD offset between the galactic disk and its bar in NGC 3906 (2015)

We use mid-infrared 3.6 and 4.5 μm imaging of NGC 3906 from the Spitzer Survey of Stellar Structure in Galaxies (S^4G) to understand the nature of an unusual offset between its stellar bar and the photometric center of an otherwise regular, circular outer stellar disk. We measure an offset of ∼910 pc between the center of the stellar bar and photometric center of the stellar disk; the bar center coincides with the kinematic center of the disk determined from previous HI observations. Although the undisturbed shape of the disk suggests that NGC 3906 has not undergone a significant merger event in its recent history, the most plausible explanation for the observed offset is an interaction. Given the relatively isolated nature of NGC 3906 this interaction could be with dark matter substructure in the galaxy's halo or from a recent interaction with a fast moving neighbor that remains to be identified. Simulations aimed at reproducing the observed offset between the stellar bar/kinematic center of the system and the photometric center of the disk are necessary to confirm this hypothesis and constrain the interaction history of the galaxy.
A STUDY ON CHARACTER-PATTERNS BASED UPON THE THEORY OF PSYCHOLOGICAL POTENTIAL FIELD (1970)

Twenty students of Ss observed modified alphabetical characters and identified their names. Those specific modifications were made by changing the length of line or dislocating some parts of character elements. The state of distribution of the fields around these characters were determined on the basis of the author's theoretical formula on the psychological potential field. The results showed that the similarity in the degree of identification of modified characters is quite consistent with that of their distribution modes of the psychological potential field.These facts are suggestive to develop automatic reading machines which can read the hand-written characters.
Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial (2014)

Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities; however, studies with larger samples and specific objectives are required before definitive conclusions can be drawn.
PREPARATION AND PHOTOPHYSICAL STUDIES OF PORPHYRIN‐C60 DYADS (1994)

Abstract Porphyrin‐C 60 dyads in which the two chromophores are linked by a bicyclic bridge have been synthesized using the Diels‐Alder reaction. The porphyin singlet lifetimes of both the zinc (Pz n ‐C 60 ) and free base (P‐C 60 ) dyads, determined by time‐resolved fluorescence measurements, are ≦17 ps in toluene. This substantial quenching is due to singlet‐singlet energy transfer to C 60 The lifetime of Pzn‐ 1 C 60 is ‐5 ps in toluene, whereas the singlet lifetime of an appropriate C 60 model compound is 1.2 ns. This quenching is attributed to electron transfer to yield P zn bull; +‐C 60 bull; ‐. In toluene, P‐ 1 C 60 is unquenched; the lack of electron transfer is due to unfavorable thermodynamics. In this solvent, a transient state with an absorption maximum at 700 ran and a lifetime of‐10 μs was detected using transient absorption methods. This state was quenched by oxygen, and is assigned to the C 60 triplet. In the more polar benzonitrile, P‐ 1 C 60 underoes photoinduced electron transfer to give P • + ‐C 60 bull; ‐. The electron transfer rate constant is −2 × 10 11 s −1 .
Differential effect of plant lectins on mast cells of different origins (2005)

Histamine release induced by plant lectins was studied with emphasis on the carbohydrate specificity, external calcium requirement, metal binding sites, and mast cell heterogeneity and on the importance of antibodies bound to the mast cell membrane to the lectin effect. Peritoneal mast cells were obtained by direct lavage of the rat peritoneal cavity and guinea pig intestine and hamster cheek pouch mast cells were obtained by dispersion with collagenase type IA. Histamine release was induced with concanavalin A (Con A), lectins from Canavalia brasiliensis, mannose-specific Cymbosema roseum, Maackia amurensis, Parkia platycephala, Triticum vulgaris (WGA), and demetallized Con A and C. brasiliensis, using 1-300 microg/ml lectin concentrations applied to Wistar rat peritoneal mast cells, peaking on 26.9, 21.0, 29.1, 24.9, 17.2, 10.7, 19.9, and 41.5%, respectively. This effect was inhibited in the absence of extracellular calcium. The lectins were also active on hamster cheek pouch mast cells (except demetallized Con A) and on Rowett nude rat (animal free of immunoglobulins) peritoneal mast cells (except for mannose-specific C. roseum, P. platycephala and WGA). No effect was observed in guinea pig intestine mast cells. Glucose-saturated Con A and C. brasiliensis also released histamine from Wistar rat peritoneal mast cells. These results suggest that histamine release induced by lectins is influenced by the heterogeneity of mast cells and depends on extracellular calcium. The results also suggest that this histamine release might occur by alternative mechanisms, because the usual mechanism of lectins is related to their binding properties to metals from which depend the binding to sugars, which would be their sites to bind to immunoglobulins. In the present study, we show that the histamine release by lectins was also induced by demetallized lectins and by sugar-saturated lectins (which would avoid their binding to other sugars). Additionally, the lectins also released histamine from Rowett nude mast cells that are free of immunoglobulins.
Structure‐activity relationships of vanilloid receptor agonists for arteriolar TRPV1 (2011)

Arteriolar TRPV1 have different pharmacological properties from those located on sensory neurons in the rat.
Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair (2015)

The peripheral nervous system has a limited innate capacity for self-repair following injury, and surgical intervention is often required. For injuries greater than a few millimeters autografting is standard practice although it is associated with donor site morbidity and is limited in its availability. Because of this, nerve guidance conduits (NGCs) can be viewed as an advantageous alternative, but currently have limited efficacy for short and large injury gaps in comparison to autograft. Current commercially available NGC designs rely on existing regulatory approved materials and traditional production methods, limiting improvement of their design. The aim of this study was to establish a novel method for NGC manufacture using a custom built laser-based microstereolithography (μSL) setup that incorporated a 405 nm laser source to produce 3D constructs with ∼ 50 μm resolution from a photocurable poly(ethylene glycol) resin. These were evaluated by SEM, in vitro neuronal, Schwann and dorsal root ganglion culture and in vivo using a thy-1-YFP-H mouse common fibular nerve injury model. NGCs with dimensions of 1 mm internal diameter × 5 mm length with a wall thickness of 250 μm were fabricated and capable of supporting re-innervation across a 3 mm injury gap after 21 days, with results close to that of an autograft control. The study provides a technology platform for the rapid microfabrication of biocompatible materials, a novel method for in vivo evaluation, and a benchmark for future development in more advanced NGC designs, biodegradable and larger device sizes, and longer-term implantation studies.
Effects of controlled-released morphine on quality of life for cancer pain. (1989)

Oncology nursing is concerned with pain relief and overall Quality of Life (QOL). The purpose of this study was to determine the effects of controlled-release morphine on QOL for patients with cancer. Eighty-three subjects were randomly assigned in a clinical trial of short-acting versus controlled-release analgesia (MS Contin, Purdue Frederick Co., Norwalk, CT). Data was collected in a repeated measures design every 2 weeks for 6 weeks yielding a total of 240 visits. Five instruments were used to assess QOL, pain, and functional status. Study findings indicate improved pain management with controlled-release MS Contin and important nursing implications for the management of analgesia-induced gastrointestinal symptoms. Through appropriate pain management with pain therapies such as controlled-release analgesia, nurses can greatly enhance QOL for the patient with cancer.
Sequence of the protease inhibitor domain of the A4 amyloid protein precursor ofMus domesticus (1989)

Journal Article Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus Get access Ken-ichiro Fukuchi, Ken-ichiro Fukuchi 1Departments of 'Pathology Division of Medical Genetics, University of WashingtonSeattle, WA 98195, USA2Departments of Medicine Division of Medical Genetics, University of WashingtonSeattle, WA 98195, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar George M. Martin, George M. Martin 1Departments of 'Pathology Division of Medical Genetics, University of WashingtonSeattle, WA 98195, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Samir S. Deeb Samir S. Deeb * 2Departments of Medicine Division of Medical Genetics, University of WashingtonSeattle, WA 98195, USA * To whom corresspondance should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 13, 11 July 1989, Page 5396, https://doi.org/10.1093/nar/17.13.5396 Published: 11 July 1989 Article history Received: 15 May 1989 Published: 11 July 1989
A split‐mouth comparative study up to 16 years of two screw‐shaped titanium implant systems (2010)

The study failed to demonstrate significant differences in the outcome of the peri-implant bone for two implant systems with different surface characteristics. The marginal bone level around oral implants changed <0.5 mm after 15 years of loading.
Characteristics of Optical Fibres for Communications (2004)

This chapter contains sections titled: The Structure of Optical Fibres Modes of an Optical Fibre Numerical Aperture and Acceptance Angle Dispersion in Optical Fibres Single-mode Fibres: Mode Profile, Mode-field Diameter, and Spot Size Normalised Frequency, Normalised Propagation Constant, and Cutoff Wavelength References
Synthetic spatial coherence function for optical tomography and profilometry: Simultaneous realization of longitudinal coherence scan and phase shift (2002)

A new scheme for synthesizing three-dimensional longitudinal spatial coherence function is proposed. By manipulating the irradiance of an extended quasi-monochromatic spatially incoherent source with a spatial light modulator, we generated a special optical field that exhibits high coherence selectively for the specified location along the optical axis of propagation and for the specified inclination between the two mirrors in the interferometer. The feasibility of the proposed principle is demonstrated by measuring a step height made by standard gauge blocks. The proposed scheme permits one to perform phase shift without recourse to mechanical movement. The quantitative experimental proof of the principle is presented.
ChemInform Abstract: ALLENYLDIENE ELECTROCYCLIZATION, A STEREOSPECIFIC TANDEM CENTER‐AXIS‐CENTER CHIRALITY TRANSFER: SYNTHESIS OF DRIMATRIENES AND RELATED TRANS‐DECALINS (1985)

Abstract Die Beobachtung, daß Vinylallen‐Systeme wie (VII) anstelle ′von sigmatropen Umlagerungen elektrocyclische Reaktionen eingehen, wird zur Synthese von Driman‐ Derivaten ausgenutzt.