gebhart/patrepeval huggingface dataset:
Estabilização de Cu(III) em meio contendo peptídeos: estudos eletroquímicos e aplicações analíticas (2018)

\n Neste trabalho são apresentados alguns resultados relacionados a estudos sobre o comportamento eletroquímico do Cu(II) em meio contendo diferentes peptídeos (tri, tetra e pentaglicina) em função da acidez utilizando-se voltametria cíclica. Os experimentos foram realizados em uma faixa de pH entre 7,0 e 10,0. Experimentos espectrofotométricos e coulométricos também foram feitos, ambos para se caracterizar as espécies de Cu(II) e Cu(III) em solução e provar a existência da degradação dos complexos de Cu(III). Além disso, experimentos para esses sistemas também foram realizados em diferentes temperaturas utilizando eletrodo rotativo na configuração disco-anel. Estudos eletroanalíticos demonstraram a potencialidade de se empregar o sistema Cu(II)/Cu(III) no desenvolvimento de metodologia eletroanalítica para a determinação de sulfito. Neste contexto, um método amperométrico indireto para a determinação de sulfito em fluxo é proposto neste trabalho. O método baseia-se na medida amperométrica (OV vs Ag/AgCI (sat. NaCI)) do Cu(III) gerado quimicamente no processo de auto¬-oxidação do S(IV) em soluções de Cu(II)/tetraglicina na presença de traços de Ni(II) utilizando uma célula em fluxo com sistema adequado para separação de gases. A oxidação espontânea do complexo pelo oxigênio dissolvido e S(IV) é muito lenta ao contrário do que ocorre quando há traços de Ni(II). A faixa de trabalho foi de 20-100 &amp;#181;moIL-1 com limite de detecção de 2&amp;#181;moIL-1 (S/N=3). A repetibilidade para a determinação (100&amp;#181;moIL-1) levou a um desvio de 4,9% (n = 38), valor superior aos encontrados na literatura para determinações de sulfito em vinho por FIA com detecção amperométrica indireta (1-4,6%), e a freqüência analítica foi de 40h-1, valor coerente com os dos outros métodos amperométricos. Ambas as análises de sulfito em amostras de vinhos e de sucos tiveram seus resultados comparados com aqueles obtidos utilizando-se o método padrão.\n
Kidney Transplantation Under a Tolerogenic Regimen of Recipient Pretreatment and Low-Dose Postoperative Immunosuppression With Subsequent Weaning (2003)

With this approach to immunosuppression, it has been possible to avoid early posttransplant overimmunosuppression and thereby to promote the evolution of a degree of partial tolerance sufficient to undertake substantial dose reduction. The strategy, which is applicable for all organ grafts, constitutes a paradigm shift in transplant management at our center.
Synthesis, Reactivity, And Applications Of P-nitrophenyl 3-diazopyruvate And 3-diazopyruvamides (cross-linking, Cyclopeptides). (1986)

p-Nitrophenyl 3-diazopyruvate (PNPDAP) has been developed as a reagent for the modification of proteins, and as a synthon for organic synthesis. PNPDAP alkylates primary and secondary amines to form 3-diazopyruvamides in high yields. 3-Diazopyruvamide derivatives have been formed from a wide variety of amines including aromatic amines, amino acids, and peptides. 3-Diazopyruvamides undergo photolysis and Wolff rearrangement at 300 nm to produce a ketene amide which efficiently acylates nucleophilic species to form malonic acid amide derivatives. PNPDAP was made available to a number of researchers and has been found to be an efficient photoactivatable cross-linking agent. Metal-catalyzed decompositions of 3-diazopyruvamides to produce carbenoids were not found to be synthetically useful. Lewis acid catalyzed addition of hydroxy nucleophiles to the diazoketone forms 3-aryloxy-, 3-alkyloxy-, and 3-acyloxypyruvamide derivatives. Cyclization of a 3-diazopyruvamide tripeptide by formation of the aryl ether bond of a cyclopeptide ring skeleton failed. 3-Diazopyruvamides react efficiently with hydrochloric acid to produce 3-chloropyruvamides which rapidly alkylate thiol nucleophiles. Reactions aimed at the development of 3-chloropyruvamides as affinity labels and cross-linking agents were investigated. A model 3-chloropyruvamide cross-linking agent could be cleaved after reaction with p-thiocresole, by oxidation with hydrogen peroxide. A family of hetero-bifunctional, photoactivatable 3-diazopyruvamide cross-linking agents was synthesized from amino acids. A cleavable, photoactivatable cross-linking agent as synthesized from cystamine. All of these reagents and the 3-chloropyruvamide reagent were reacted with rabbit muscle aldolase to form dimeric cross-linked species.
Prevalence and Incidence of Urinary Incontinence in a Diverse Population of Women With Noncancerous Gynecologic Conditions (2010)

OBJECTIVE: To determine the prevalence and incidence of urinary incontinence (UI) in a diverse cohort of women presenting with noncancerous gynecologic conditions and to assess factors associated with UI prevalence and incidence. METHODS: We conducted a secondary analysis of data from SOPHIA (Study of Pelvic Problems, Hysterectomy and Intervention Alternatives), a longitudinal study of women with noncancerous gynecologic conditions (bleeding, pelvic pain, and symptomatic fibroids). UI was defined as incontinence in the last 4 weeks as reported on interviewer-administered annual questionnaires. We also evaluated the type of UI: stress (SUI), urge (UUI) or mixed incontinence (MUI). RESULTS: The study population of 907 women was 40.8% White, 28.0% African American, 17.3% Latina and 8.1% Asian. The mean age was 44.1 ± 5.4 years and 48.5% had an annual household income of ≤$50,000. The overall prevalence of any UI was 51.1%. At baseline, SUI was the most common at 39.4% followed by UUI at 23.7% and MUI at 18.9%. The average annual incidence for any UI was 4.2%. 13% of the women who underwent hysterectomy developed incident UI after their surgery. In multivariable logistic regression analysis, prevalent UI was associated with the following: age in decades (OR 1.6, 95% CI 1.2, 2.2), Latina race/ethnicity compared to white (OR 2.1, 95% CI 1.3, 3.3), and parity (OR 1.7, 95% CI 1.2, 2.4). None of the factors evaluated were associated with incidence of UI. CONCLUSION: Urinary incontinence is very common in women seeking care for noncancerous gynecologic conditions, particularly among older, parous Latinas.
Application of Heterogeneous Catalysts for Organic Synthesis by Controlling the Oxidation State of Metal Species (2013)

One of the important research topics in the synthesis of pharmaceuticals and fine chemicals is to convert homogeneous reactions to heterogeneous versions by immobilization of metal species on polymer or inorganic supports. The oxidation state of the metal species can affect the character and reactivity of the catalyst. Recently, chemists have gained excellent techniques to control particle size and oxidation state of metal species, which has led to the development of new heterogeneous catalysts for organic reactions.
Seamless Fast Handover in Mobile IPv4 Using Layer-2 Triggers (2007)

In this paper, we propose a new layer-3 (L3) handover scheme which is able to provide the more seamless service than the existing schemes even without buffer. The proposed scheme uses layer-2(L2) triggers and applies the tunnel mechanism and pre- registration method of the low latency handoff scheme in mobile IPv4 (LLH) [1] simultaneously. The tunnel is used to transfer the traffic to the mobile node (MN), which has registered the care-of address of new foreign agent (FA) with home agent (HA) while being still connected to the subnet of the old FA, until the MN connects to the new link By simulation, we prove its enhanced performance in terms of throughput, delivery rate, end-to-end packet transmission delay, and delay jitter.
Biometrics security system: A review of multimodal biometrics based techniques for generating crypto-key (2015)

In today's world the life is very fast we want to do everything so quickly and easily without putting much physical and mental effort. With the advancement of technology we are provided with higher level of knowledge through the invention of different devices. However each technological innovation has its pros and cons. One of the emerging devise for biometric security system is Smartphone's we are using today. Today we cannot think of living without smart phones as they have become the part of our life. We depend on our phone for our so man day to day activities like paying bills connecting with friends and office, making money transaction. But using the traditional security features we cannot get appropriate security as anyone who knows the password to unlock my phone can get access to my phone. Using biometrics traits like fingerprint, voice, face, and iris one cannot get access to the device. In this paper we focus on how biometrics help in making the device more secure and fool proof and what were the lacking in the traditional methods of security system which give birth to the implementation of biometric security system.
Effects of Powder Shape and Processing Parameters on Heat Dissipation of Heat Pipes with Sintered Porous Wicks (2009)

The thermal performance of sintered-type heat pipes can be determined from their permeability, capillary pressure, and capillary speed. These characteristics are closely related to the pore structure, which is influenced by the powder used. To investigate the effects of powder shape on the heat dissipation of a heat pipe, gas atomized, water atomized, and electrolytic copper powders were used in this study. The results showed that the gas atomized spherical powder, despite having the lowest porosity, provided the highest permeability and capillary speed and thus the best heat dissipation. The water atomized irregular powder had a smaller permeability, slightly higher capillary speed, and better thermal performance compared to dendritic electrolytic powder. These results suggest that capillary speed is favorable over the permeability for evaluating whether a copper powder is suitable for heat pipe applications or not. The geometrical factor in the Kozeny-Carman permeability equation, which takes into account the effective pore length, pore surface roughness, and tortuosity, could vary from the 250 of the spherical powder to the 3108 of the dendritic powder for compacts with similar permeabilities, showing the effect of powder shape. The processing parameters, compacting pressure and sintering temperature, were also important. Compacts that were loose-powder-sintered at high temperatures showed higher permeability than those using compaction and low temperature sintering due to the differences in the pore surface roughness. These results demonstrate that the thermal performance of heat pipes is closely related to the powder shape and the process used, in addition to the effects of particle size and particle size distribution.
Structural and Functional Analysis of Urease Accessory Protein E fromVancomycin-Resistance Staphylococcus aureus MU50 Strain (2023)

Structural studies on VRSA urease accessory proteins could aid in the identification of new drug targets or the development of effective antibiofilm strategies (in combination with other drug targets) against infections caused by biofilm-producing strains.
A general purpose temperature controller (1980)

A simple, inexpensive temperature controller is described. This controller is capable of maintaining temperatures constant to less than 100 mu K in a variety of thermostats. It uses a thermistor in a DC Wheatstone bridge. The simplicity of DC detection allows the use of readily available electronic components, and ensures a low total cost. Furthermore, thermostatting of the electronics is generally not necessary.
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade (2002)

Glutamate, one of the excitatory neurotransmitters, contributes to the neuronal death associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and with ischemia. In Alzheimer's disease brains, there is a decreased number of dopamine D2 receptors, which might cause neuronal dysfunction or death. In the present study, bromocriptine exerted a protective effect against glutamate-induced cytotoxicity in rat cortical neurons. This neuroprotective effect was mediated via D2 receptors, because it was attenuated by domperidone, a D2 dopaminergic receptor antagonist. Another dopamine D2 agonist, quinpirole, also protected cells against glutamate toxicity. D2 agonists protected cells from calcium influx, nitric oxide, and peroxynitrite toxicity, which are thought to be the mediators of glutamate toxicity. The phosphatidylinositol 3 kinase (PI3K) inhibitor (LY294002) inhibited this neuroprotective effect of bromocriptine, in contrast to the mitogen-activated protein kinase kinase (MAPKK) inhibitor (PD98059), which did not counter the protective effect. Furthermore, Akt protein kinase, which is an effector of PI3K, was activated by bromocriptine, and the antiapoptotic protein Bcl-2 was up-regulated by bromocriptine treatment. These results suggest that D2 dopaminergic receptor activation plays an important role in neuroprotection against glutamate cytotoxicity and that the up-regulation of Bcl-2 expression via the PI3K cascade is, at least partially, involved in this effect.
CH and CC Bond Activation by Bare Transition‐Metal Oxide Cations in the Gas Phase (1995)

Abstract Over the last decade the gas‐phase chemistry of bare transition‐metal oxide cations MO + has received considerable attention. This interest is primarily due to the particular role of metal oxides in the oxidation of organic compounds in a variety of chemical and biochemical transformations. At a molecular level the simplest model system for these processes deals with reactions of bare metal‐oxide ions in the gas phase. Due to the high oxophilicities of the early transition metals, their monoxide cations MO + do not mediate O‐atom transfer to any organic compounds at all. In contrast, monoxide cations of late transition metal can oxygenate a variety of hydro‐carbons, and the most reactive ions, MnO + , FeO + , NiO + , OsO + , and PtO + , even activate methane. Insight into the reaction mechanisms of these oxidation processes can be obtained by analysis of reaction kinetics, isotope effects, product distributions etc., and for the reactions of MO + with alkanes the initial CH bond activation by MO + is often rate‐determining. Interestingly, the high reactivity of some MO + ions is not always associated with a decrease in regioselectivity; for example, FeO + ions induce regiospecific γ‐CH bond activation of dialkylketones in the gas phase. The situation for the epoxidation of olefins in the gas phase turns out to be even more complex than for condensedphase analogues. This is primarily because the metal ion that mediates O‐atom transfer to the olefin also catalyzes the isomerization of the epoxides formed, to afford the energetically more stable aldehydes or ketones. Aromatic compounds can also be hydroxylated by MO + ions, and particularly the oxidation of benzene by bare FeO + ions in the gas phase reveals striking parallels to the metabolism of arenes. Furthermore, the storing capabilities of ion cyclotron resonance mass spectrometers even permit the design of catalytic processes in which a single metal ion converts more than one substrate molecule into an oxygenated product in a sequence of strictly bimolecular reactions. The most outstanding examples are the Pt + ‐mediated oxidation of methane by molecular oxygen and the Co + ‐mediated hydroxylation of benzene by N 2 O as oxidant. Finally, the key features of the gas‐phase reactions are compared with observations in condensed‐phase systems in which metal oxides are anticipated as central intermediates. The result of this comparison is promising in the sense that, in general, the understanding of transition‐metal‐mediated oxidations in the gas phase may lead to a more uniform description of these processes at a molecular level. Ultimately, it is hoped that gas‐phase studies will serve as one of the building blocks in the evolution of tailor‐made catalysts.
Authors of Their Lives: The Personal Correspondence of British Immigrants to North America in the Nineteenth Century (2005)

2008 United States Postal System's Rita Lloyd Moroney AwardIn the era before airplanes and e-mail, how did immigrants keep in touch with loved ones in their homelands, as well as preserve links with pasts that were rooted in places from which they voluntarily left? Regardless of literacy level, they wrote letters, explains David A. Gerber in this path-breaking study of British immigrants to the U.S. and Canada who wrote and received letters during the nineteenth century.Scholars have long used immigrant letters as a lens to examine the experiences of immigrant groups and the communities they build in their new homelands. Yet immigrants as individual letter writers have not received significant attention; rather, their letters are often used to add color to narratives informed by other types of sources.Authors of Their Lives analyzes the cycle of correspondence between immigrants and their homelands, paying particular attention to the role played by letters in reformulating relationships made vulnerable by separation. Letters provided sources of continuity in lives disrupted by movement across vast spaces that disrupted personal identities, which depend on continuity between past and present. Gerber reveals how ordinary artisans, farmers, factory workers, and housewives engaged in correspondence that lasted for years and addressed subjects of the most profound emotional and practical significance
Effect of State Workplace Safety Laws on Occupational Injury Rates (2001)

The purpose of this study was to evaluate the effect of four common types of mandatory state-level workplace safety regulations on injury severity rates during the period 1992 to 1997 for the manufacturing sector. The full Poisson regression model showed safety committee regulations to have a highly significant reducing effect on injury rates, chi 2 (1, n = 3286) = 10.1774, P = 0.0014. Safety program regulations were significant at the alpha = 0.10 level, chi 2 (1, n = 3286) = 3.5676, P = 0.0589. The effect of insurance carrier loss control regulations in the full model was nonsignificant. However, insurance carrier loss control regulations were highly significant (alpha = 0.01) in the final reduced model. Targeting initiatives were nonsignificant in both the full and reduced models (alpha = 0.05). The study results are important to state and federal agencies considering adopting workplace safety regulations that are similar to the four types evaluated in this study.
Exploring friend's influence in cultures in Twitter (2013)

What does a user do when he logs in to the Twitter website? Does he merely browse through the tweets of all his friends as a source of information for his own tweets, or does he simply tweet a message of his own personal interest? Does he skim through the tweets of all his friends or only of a selected few? A number of factors might influence a user in these decisions. Does this social influence vary across cultures? In our work, we propose a simple yet effective model to predict the behavior of a user - in terms of which hashtag or named entity he might include in his future tweets. We have approached the problem as a classification task with the various influences contributing as features. Further, we analyze the contribution of the weights of the different features. Using our model we analyze data from different cultures and discover interesting differences in social influence.
A mathematical model of ischemic cutaneous wounds (2009)

Chronic wounds represent a major public health problem affecting 6.5 million people in the United States. Ischemia, primarily caused by peripheral artery diseases, represents a major complicating factor in cutaneous wound healing. In this work, we sought to develop a mathematical model of ischemic dermal wounds. The model consists of a coupled system of partial differential equations in the partially healed region, with the wound boundary as a free boundary. The extracellular matrix (ECM) is assumed to be viscoelastic, and the free boundary moves with the velocity of the ECM at the boundary. The model equations involve the concentration of oxygen, PDGF and VEGF, the densities of macrophages, fibroblasts, capillary tips and sprouts, and the density and velocity of the ECM. Simulations of the model demonstrate how ischemic conditions may limit macrophage recruitment to the wound-site and impair wound closure. The results are in general agreement with experimental findings.
Electron paramagnetic resonance studies of tetrasulfur tetranitride in sulfuric acid (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron paramagnetic resonance studies of tetrasulfur tetranitride in sulfuric acidSteven A. Lipp, James J. Chang, and William L. JollyCite this: Inorg. Chem. 1970, 9, 9, 1970–1973Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/ic50091a002https://doi.org/10.1021/ic50091a002research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France (2020)

ABSTRACT An indirect immunofluorescent assay was developed in order to assess the serological status of 888 RT-PCR-confirmed COVID-19 patients (1,302 serum samples) and controls in Marseille, France. Incorporating an inactivated clinical SARS CoV-2 isolate as the antigen, the specificity of the assay was measured as 100% for IgA titre ≥ 1:200; 98.6% for IgM titre ≥ 1:200; and 96.3% for IgG titre ≥ 1:100 after testing a series of negative controls as well as 150 serums collected from patients with non-SARS-CoV-2 Coronavirus infection, non-Coronavirus pneumonia and infections known to elicit false-positive serology. Seroprevalence was then measured at 3% before a five-day evolution up to 47% after more than 15 days of evolution. We observed that the seroprevalence as well as the titre of specific antibodies were both significantly higher in patients with a poor clinical outcome than in patients with a favourable evolution. These data, which have to be integrated into the ongoing understanding of the immunological phase of the infection, suggest that serotherapy may not be a therapeutic option in patients with severe COVID-19 infection. The IFA assay reported here is useful for monitoring SARS-CoV-2 exposure at the individual and population levels.