gebhart/patrepeval huggingface dataset:
Data from Molecular Characterization and Prospective Evaluation of Pathologic Response and Outcomes with Neoadjuvant Therapy in Metaplastic Triple-Negative Breast Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer that is commonly triple-negative and poorly responsive to neoadjuvant therapy in retrospective studies.&lt;/p&gt;Experimental Design:&lt;p&gt;To better define clinical outcomes and correlates of response, we analyzed the rate of pathologic complete response (pCR) to neoadjuvant therapy, survival outcomes, and genomic and transcriptomic profiles of the pretreatment tumors in a prospective clinical trial (NCT02276443). A total of 211 patients with triple-negative breast cancer (TNBC), including 39 with MpBC, received doxorubicin-cyclophosphamide–based neoadjuvant therapy.&lt;/p&gt;Results:&lt;p&gt;Although not meeting the threshold for statistical significance, patients with MpBCs were less likely to experience a pCR (23% vs. 40%; &lt;i&gt;P&lt;/i&gt; = 0.07), had shorter event-free survival (29.4 vs. 32.2 months, &lt;i&gt;P&lt;/i&gt; = 0.15), metastasis-free survival (30.3 vs. 32.4 months, &lt;i&gt;P&lt;/i&gt; = 0.22); and overall survival (32.6 vs. 34.3 months, &lt;i&gt;P&lt;/i&gt; = 0.21). This heterogeneity is mirrored in the molecular profiling. Mutations in &lt;i&gt;PI3KCA&lt;/i&gt; (23% vs. 9%, &lt;i&gt;P&lt;/i&gt; = 0.07) and its pathway (41% vs. 18%, &lt;i&gt;P&lt;/i&gt; = 0.02) were frequently observed and enriched in MpBCs. The gene expression profiles of each histologically defined subtype were distinguishable and characterized by distinctive gene signatures. Among nonmetaplastic (non-Mp) TNBCs, 10% possessed a metaplastic-like gene expression signature and had pCR rates and survival outcomes similar to MpBC.&lt;/p&gt;Conclusions:&lt;p&gt;Further investigations will determine if metaplastic-like tumors should be treated more similarly to MpBC in the clinic. The 23% pCR rate in this study suggests that patients with MpBC should be considered for NAT. To improve this rate, a pathway analysis predicted enrichment of histone deacetylase (HDAC) and RTK/MAPK pathways in MpBC, which may serve as new targetable vulnerabilities.&lt;/p&gt;&lt;/div&gt;
Aurora Kinase B (2020)

Aurora kinase B (344 aa, ~39 kDa) is encoded by the human AURKB gene. This protein plays a role in both the modulation of microtubule structure and facilitation of chromosome segregation during mitosis and meiosis.
[Acute myocardial infarction: time delay from onset of pain to hospital presentation and thrombolysis]. (2000)

75% of patients with acute chest pain arrived at the hospital within 6 hours of onset of symptoms. Most of the delay was caused by the patients themselves, a factor which needs to be improved by better education. Moreover, optimising in-hospital processes should further shorten the delay to thrombolysis.
Model‐Based Learning Controls And Their Comparisons Using Lyapunov Direct Method (2002)

ABSTRACT Model‐based learning control of nonlinear systems is studied. Two types of learning algorithms, described by differential equations and/or difference equations to learn unknown time functions, are designed and compared using the Lyapunov's direct method. The time functions to be learned are classified into several classes according to their properties such as continuity, periodicity, and value at the origin of the state space. Conditions are found for iterative learning controls to achieve asymptotic stability and asymptotic learning convergence. For a comparative study, learning capability of a control is defined and, using the criterion, other model‐based controls with learning capability such as adaptive controls and robust controls are investigated. Through the study, iterative learning control is shown to be the one best suited for learning unknown time functions of known period. Finally, it is shown for the first time that an iterative learning control is directly applicable to systems described by nonlinear partial differential equation.
Nanometer Scale Axial Localization of Fluorescent Emitters for Cellular Imaging (2007)

Nanometer scale axial localization of fluorescent monolayers is demonstrated by utilizing self-interference of fluorescence in a 4Pi Type C confocal microscope.
Autotandem Catalysis: Inexpensive and Green Access to Functionalized Ketones by Intermolecular Iron‐Catalyzed Amidoalkynylation/Hydration Cascade Reaction via N‐Acyliminium Ion Chemistry (2021)

Iron-based catalysts were applied in cascade-type reactions for the synthesis of different carbonyl compounds. The reactions proceeded by a new iron-catalyzed cascade of alkynylation/hydration by using both the σ- and π-Lewis acid properties of iron salts. The alkynylation reactions of several endo and exocyclic acetoxylactams were achieved with three different catalysts including FeCl<sub>3</sub> ⋅ 6H<sub>2</sub> O, FeCl<sub>3</sub> , and Fe(OTf)<sub>3</sub> showing the efficiency of σ-Lewis acidity of iron (III) salts in catalyzing the alkynylation reaction. We also demonstrated that the reaction sequence could be shortened by the direct use of hydroxylactams, leading to an environmentally friendly protocol, avoiding the need to perform unnecessary lengthy steps. A combination of the hard/soft iron Lewis acid properties was then used to implement an unprecedented tandem intermolecular alkynylation/intramolecular hydration sequence allowing expedient access to a new carbonyl structures from trivial materials.
Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients (2003)

We describe a new one-step RT-PCR assay for the detection of the mammaglobin (MGB1) gene transcript in the peripheral blood of breast cancer patients. With this approach, the MGB1 transcript could be detected in the peripheral blood of 22 of 54 (41%) breast cancer patients prior to any therapy. This method, using specific primers for cDNA synthesis, proved to be more sensitive (10(-6) to 10(-11), usually 10(-7)) than previously reported methodologies. This increased sensitivity was achieved without compromising specificity, as the MGB1 transcript was not detected in 38 blood samples of healthy donors and in only 1 of 18 blood samples of patients presenting with hematologic malignancies. A positive correlation was seen between MGB1 positivity and breast cancer stage: 0/3 (0%) in stage 0, 3/13 (23%) in stage I, 6/17 (35%) in stage II, 5/10 (50%) in stage III, 8/11 (73%) in stage IV (p = 0.003). The prognostic and therapeutic implications of MGB1 positivity by one-step RT-PCR in the peripheral blood of breast cancer patients, especially in clinically localized disease (stages I and II), should be evaluated after long-term clinical follow-up of these patients.
In vitro Study Anti-proliferative Potential of Algae Extract against Cancer Cell Line (2019)

Background: Oxidative stress is defined as imbalance between oxidant and antioxidant ratio, that lead to oxidative damage of biologically active molecules, finally lead to different disease and initiate carcinogenesis. The drug discovery using natural products as medicinal plants or marine organism still an important target for recent research. This study investigated anticancer activity of algae extract obtained from Red sea at Jeddah.&#x0D; Materials and Methods: Aqueousand methanol extracts ofDictyotaciliolata(DC) were tested on HCT-116 and HepG2 cell lines using WST-1. Aqueous extract (AEDC) and methanol extract (MEDC) at doses 0.05, 0.1, 0.5, 1 mg/ml and positive control 0.3% H2O2 at doses 0.5 mg/ml for 24,48 and 72 h (for two cell lines).&#x0D; Results: AEDC showed the mosteffective antitumor activity against HCT116 and HePG2, the IC50 dose for HCT116 cells was 0.05 mg/ml at 72 h, while for the HePG2 it was 0.01 mg/ml at 72 h. These results showed that HePG2cells was more sensitive to the AEDC. However, IC50 for MEDC were 0.01 mg/ml for HCT116 and 0.05 for HepG2 at 48 Hrs. The algae extracts contain sulfated polysaccharides and different pigments as chlorophylls, carotenoids and phycobiliproteins. These pigments were approved as biological active biomolecules that exert different biological activities as antioxidants, antitumor and rich source of micronutrients. In addition, AEDC or MEDC exert apoptotic activity by increase activity of caspase 3 and 9 in HepG2.&#x0D; Conclusıon: The antitumor effect of AEDC or MEDC is promising for development of chemotherapeutic agent as effective with no side effects.
Computational Discovery of Complex Material Systems by Design Optimization (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-1269.vid Complexity in a material’s structure, along with that of the geometrical elements’ individual and collective responses, enables the emergence of extraordinary properties. The principles underlying these properties have begun to be unlocked via research into metamaterial and mesoscale architected materials. The practical realization of these materials has been enabled by advanced manufacturing (e.g. additive manufacturing) which can control design features of one or more materials at unprecedented scale. We will present our new digital engineering approach to discover transformational materials for mitigating impacts via formulating a multiscale optimization approach.
PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, VOLUME 51, RHIC SPIN COLLABORATION MEETINGS XV AND XVI. (2003)

The Center is dedicated to the study of strong interactions, including spin physics, lattice QCD, and RHIC physics through the nurturing of a new generation of young physicists.
Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer —Association With Patient and Disease Characteristics and Effect on Prognosis (2021)

Multigene panel testing may be considered in all patients with mBC because of the high frequency of germline mutations in <i>BRCA1/2</i> and other BC predisposition genes. Although the prognosis of mutation carriers and nonmutation carriers with mBC was similar, differences observed in tumor characteristics have implications for treatment and for future studies of targeted therapies.
IRS-Enhanced OFDMA: Joint Resource Allocation and Passive Beamforming Optimization (2019)

Intelligent reflecting surface (IRS) is an emerging technique to enhance the wireless communication spectral efficiency with low hardware and energy cost. In this letter, we consider the integration of IRS to an orthogonal frequency division multiple access (OFDMA) based multiuser downlink communication system, and study the pertinent joint optimization of the IRS reflection coefficients and OFDMA time-frequency resource block as well as power allocations to maximize the users' common (minimum) rate. Specifically, due to the lack of frequency-selective passive beamforming capability at the IRS, only one set of reflection coefficients can be designed for adapting to a large number of channels of multiple users over different frequency sub-bands. To tackle this difficulty, we propose a novel dynamic passive beamforming scheme where the IRS reflection coefficients are dynamically adjusted over different time slots within each channel coherence block to create artificial time-varying channels and select only a subset of the users to be simultaneously served in each time slot, thus achieving a higher passive beamforming gain. Although the formulated optimization problem is non-convex, we propose an efficient algorithm to obtain a suboptimal solution to it. Numerical results show that the proposed scheme significantly improves the system common rate over the setup without IRS and that with random IRS reflection coefficients. Moreover, our proposed dynamic passive beamforming outperforms the fixed passive beamforming which employs a common set of reflection coefficients in each channel coherence block, by more flexibly balancing between passive beamforming and multiuser diversity gains.
Effect of Phosphate Supplements on Cavitation in Hamsters Infected with Caries-Conducive Streptococci (1970)

Anticavitation findings from this study on the administration of phosphated compounds in a caries-inducing ration to hamsters coincide with the findings of other investigations in rats, but indicate that a regimen of phosphate supplements tends to lose its retarding effect on cavitation unless administered continuously.
Improved Reproducibility and Intercalation Control of Efficient Planar Inorganic Perovskite Solar Cells by Simple Alternate Vacuum Deposition of PbI2 and CsI (2017)

Vacuum deposition is a simple and controllable approach that aims to form higher-quality perovskite films compared with those formed using solution-based deposition processes. Herein, we demonstrate a novel method to promote the intercalation control of inorganic cesium lead iodide (CsPbI<sub>3</sub>) perovskite thin films via alternate vacuum deposition. We also investigated the effect of layer-by-layer deposition of PbI<sub>2</sub>/CsI to fabricate efficient planar heterojunction CsPbI<sub>3</sub> thin films and solar cells. This procedure is comparatively simple when compared with commonly used coevaporation techniques; further, precise intercalation control of the CsPbI<sub>3</sub> thin films can be achieved by increasing the number of layers in the layer-by-layer deposition of PbI<sub>2</sub>/CsI. The best control and the highest reproducibility were achieved for the deposition of four double layers owing to the precise intercalation control during the deposition of the CsPbI<sub>3</sub> thin film. A power conversion efficiency of 6.79% was obtained via alternating vacuum deposition of two double layers with a short-circuit current density (<i>J</i> <sub>sc</sub>) of 12.06 mA/cm<sup>2</sup>, an open-circuit voltage (<i>V</i> <sub>oc</sub>) of 0.79 V, and a fill factor (FF) of 0.72. Our results suggest a route for inorganic precursors to be used for efficient perovskite solar cells via alternating vacuum deposition.
New one-dimensional conductors: Graphitic microtubules (1992)

On the basis of realistic tight-binding band-structure calculations, we predict that carbon microtubules exhibit striking variations in electronic transport, from metallic to semiconducting with narrow and moderate band gaps, depending on the diameter of the tubule and on the degree of helical arrangement of the carbon hexagons. The origin of this drastic variation in the band structure is explained in terms of the two-dimensional band structure of graphite.
Constrained least-squares regression in color spaces (1997)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Bio-inspired sensor skins for structural health monitoring (2009)

This paper presents the simulation and experimental work that proved the feasibility of using a patch antenna for strain measurement. A patch antenna, besides serving as a data transmitting device, can function as a transducer that directly encodes the strain experienced into its resonant frequency. Printed on a flexible substrate, the antenna sensor is small in size, has a low profile and can be conformal to any attached surface. The technique for interrogating the antenna sensor using a wireless non-contact method is also demonstrated. Without needing electric wiring for power supply and data transmitting, the antenna sensor has a great potential for the realization of engineered sensor skins that imitate the sense of pain for structural health monitoring purposes.
Energy budgets of animals: behavioral and ecological implications (1979)

This year's progress has been: (1) to extend the general microclimate model two ways: (a) to incorporate wet ground surfaces (bogs), and (b) to incorporate slope effects. Tests of the model in a Michigan bog and the Galapagos Islands show temperature accuracies to within 4/sup 0/C at worst at any soil or air location, which is about a 2% error in estimation of metabolism. (2) The addition to ectotherm modeling an analysis of: (a) reproduction in heterogeneous and uncertain environments; (b) prediction of distribution limits due to egg incubation requirements; (c) addition of appendage-torso modeling and tests on large ectotherms; (d) social systems interactions with environmental and physiological variables; and (3) to continue the endotherm (deer mouse) experimental research and extend the growth and reproduction studies to include the entire reproductive and growth cycle in the deer mouse.
Incidental findings in imaging diagnostic tests: a systematic review (2010)

The objective of this review is to summarise the available evidence on the frequency and management of incidental findings in imaging diagnostic tests. Original articles were identified by a systematic search of the MEDLINE, EMBASE and Cochrane Library Plus databases using appropriate medical headings. Extracted variables were study design; sample size; type of imaging test; initial diagnosis; frequency and location of incidental findings; whether clinical follow-up was performed; and whether a definitive diagnosis was made. Study characteristics were assessed by one reviewer and checked by a second reviewer. Any disagreement was solved by consensus. The relationship between the frequency of incidental findings and the study characteristics was assessed using a one-way ANOVA test, as was the frequency of follow-up of incidental findings and the frequency of confirmation. 251 potentially relevant abstracts were identified and 44 articles were finally included in the review. Overall, the mean frequency of incidental findings was 23.6% (95% confidence interval (CI) 15.8-31.3%). The frequency of incidental findings was higher in studies involving CT technology (mean 31.1%, 95% CI 20.1-41.9%), in patients with an unspecific initial diagnosis (mean 30.5, 95% CI 0-81.6) and when the location of the incidental findings was unspecified (mean 33.9%, 95% CI 18.1-49.7). The mean frequency of clinical follow-up was 64.5% (95% CI 52.9-76.1%) and mean frequency of clinical confirmation was 45.6% (95% CI 32.1-59.2%). Although the optimal strategy for the management of these abnormalities is still unclear, it is essential to be aware of the low clinical confirmation in findings of moderate and major importance.
Distributed acoustic sensing for shallow seismic investigations and void detection (2021)

ABSTRACT During the past few decades, fiber-optic-based distributed acoustic sensing (DAS) has emerged as an affordable, easy-to-deploy, reliable, and noninvasive technique for high-resolution seismic sensing. We have determined that fiber deployments dedicated to near-surface seismic applications, commonly used for the detection and localization of voids, can be used effectively with conventional processing techniques. We tested a variety of small sources in different geologic environments. These sources, operated on and below the surface, were recorded by horizontal and vertical DAS arrays. Our results and comparisons to data acquired by vertical-component geophones demonstrate that DAS may be sufficient for acquiring near-surface seismic data. Furthermore, we tried to address the issue of directional sensing by DAS arrays and use it to solve the problem of wave-mode separation. Records acquired by a unique acquisition setup suggest that one can use the nature of standard DAS systems as uniaxial strainmeters to record separated wave modes. Finally, we applied two seismic methods on DAS data acquired at a test site: multichannel analysis of surface waves (MASW) and shallow diffraction imaging. These methods allowed us to determine the feasibility of using DAS systems for imaging shallow subsurface voids. MASW was used to uncover anomalies in the S-wave velocity, whereas shallow diffraction imaging was applied to identify the location of the void. The results we obtained illustrate that by using these methods we are able to accurately detect the true location of the void.
Influencia del contenido de finos del hormigón en la respuesta estructural a flexión y cortante de vigas de hormigón armado (2015)

Este artículo presenta un estudio experimental sobre el comportamiento a flexión y cortante de vigas de hormigón armado con un contenido de finos (275 kg/m3) superior al límite permitido por la Instrucción EHE-08 (175 kg/m3). En el rango estudiado, el contenido de finos apenas afectó a la respuesta a flexión. La resistencia a cortante de vigas con alto contenido de finos fue menor que la de las vigas de hormigón convencional, en especial para las vigas con cuantía alta de armadura longitudinal y con armadura de cortante, con una reducción de hasta el 23 % en la carga última. Esta reducción se considera debida a la disminución de propiedades mecánicas del hormigón que afecta especialmente al cortante resistido por fricción en la fisura. Por último, los ensayos realizados han permitido verificar un modelo numérico de análisis no lineal evolutivo para predecir el comportamiento de estructuras de hormigón con distintos contenidos de finos.
Relaxation in a high-stress environment: the molecular bases of extensible cell walls and cell enlargement. (1997)

SUMMARY AND PERSPECTIVE The enlargement of plant cells involves the coordinate con- trol of wall synthesis and expansion, solute and water trans- port, membrane synthesis, Golgi secretion, ion transport, and many other processes. In this review, I have focused on the wall because it is the major control point for cell enlarge- ment. Some of the key processes that may be involved in wall enlargement are summarized in Figure 4. I offer the following speculative picture as a tentative working model for the control of wall expansion. The primary wall is initially secreted and assembled in a form that is me- chanically tough yet has “hot spots” where expansin can weaken microfibril-matrix adhesion. Expansin activity, which is modulated both by secretion of the protein to the wall and by changes in the pH and redox potential of the wall, in- duces the stress relaxation and polymer creep needed for wall enlargement and water uptake by the cell. By altering Synthesis & secretion secretion of wall polysaccharides and proteins
Experimental Image Analyzer-synthesizer based on the novel discrete orthogonal transforms (2013)

Altera's and Terasic's FPGA based (Hardware) Image Analyzer-Synthesizer (HIMANSY) is presented. The present tool has been used for both analysis and synthesis of images using the rotation angles based discrete orthogonal transforms. HIMANSY is equipped with video camera, DE2/DE3 Development Kit and LCD display. The core of the tool is based on the embedded NIOS II processor. The prototyping of novel image processing devices is possible using HIMANSY.