gebhart/patrepeval huggingface dataset:
The Immunological and Functional Measurement of Antibodies to Streptokinase before and after Streptokinase Administration (1991)

Conference Abstract| October 01 1991 The Immunological and Functional Measurement of Antibodies to Streptokinase before and after Streptokinase Administration MB Buchalter; MB Buchalter 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar G Suntharalingam; G Suntharalingam 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar I Jennings; I Jennings 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar C Hart; C Hart 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar RJ Luddington; RJ Luddington 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar PL Weissberg; PL Weissberg 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar TP Baglin TP Baglin 1Dept of Clinical Pharmacology, University of Cambridge and Dept of Haematology, Addenbrookes Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1991) 81 (s25): 13P. https://doi.org/10.1042/cs081013Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation MB Buchalter, G Suntharalingam, I Jennings, C Hart, RJ Luddington, PL Weissberg, TP Baglin; The Immunological and Functional Measurement of Antibodies to Streptokinase before and after Streptokinase Administration. Clin Sci (Lond) 1 October 1991; 81 (s25): 13P. doi: https://doi.org/10.1042/cs081013Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1991 The Biochemical Society and the Medical Research Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Four intracellular genomes direct weevil biology: Nuclear, mitochondrial, principal endosymbiont, andWolbachia (1999)

Cell physiology in the weevil Sitophilus oryzae is coordinated by three integrated genomes: nuclear, mitochondrial, and the "S. oryzae principal endosymbiont" (SOPE). SOPE, a cytoplasmic bacterium (2 x 10(3) bacteria per specialized bacteriocyte cell and 3 x 10(6) bacteria per weevil) that belongs to the proteobacteria gamma3-subgroup, is present in all weevils studied. We discovered a fourth prokaryotic genome in somatic and germ tissues of 57% of weevil strains of three species, S. oryzae, Sitophilus zeamais, and Sitophilus granarius, distributed worldwide. We assigned this Gram-negative prokaryote to the Wolbachia group (alpha-proteobacteria), on the basis of 16S rDNA sequence and fluorescence in situ DNA-RNA hybridization (FISH). Both bacteria, SOPE and Wolbachia, were selectively eliminated by combined heat and antibiotic treatments. Study of bacteria involvement in this insect's genetics and physiology revealed that SOPE, which induces the specific differentiation of the bacteriocytes, increases mitochondrial oxidative phosphorylation through the supply of pantothenic acid and riboflavin. Elimination of this gamma3-proteobacterium impairs many physiological traits. By contrast, neither the presence nor the absence of Wolbachia significantly affects the weevil's physiology. Wolbachia, disseminated throughout the body cells, is in particularly high density in the germ cells, where it causes nucleocytoplasmic incompatibility. The coexistence of two distinct types of intracellular proteobacteria at different levels of symbiont integration in insects illustrates the genetic complexity of animal tissue. Furthermore, evolutionary timing can be inferred: first nucleocytoplasm, then mitochondria, then SOPE, and finally Wolbachia. Symbiogenesis, the genetic integration of long-term associated members of different species, in the weevil appears to be a mechanism of speciation (with Wolbachia) and provides a means for animals to acquire new genes that permit better adaptation to the environment (with SOPE).
Ruthenium-catalyzed aldol and Michael reactions of nitriles. Carbon-carbon bond formation by .alpha.-C-H activation of nitriles. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium-catalyzed aldol and Michael reactions of nitriles. Carbon-carbon bond formation by .alpha.-C-H activation of nitriles.Shun-Ichi Murahashi, Takeshi Naota, Hiroshi Taki, Masahiko Mizuno, Hikaru Takaya, Sanshiro Komiya, Yuji Mizuho, Naohiko Oyasato, Makiko Hiraoka, and Cite this: J. Am. Chem. Soc. 1995, 117, 50, 12436–12451Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00155a008https://doi.org/10.1021/ja00155a008research-articleACS PublicationsRequest reuse permissionsArticle Views2315Altmetric-Citations180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information Get e-Alerts
GaInNAs for multi-junction tandem solar cells (2003)

We have investigated the effect of atomic H irradiation on the growth of GaInNAs/GaAs films in hydrogen-assisted RF-molecular beam epitaxy (RF-MBE) from the viewpoint of growth dynamics and material quality. The crystal quality of GaInNAs films was characterized by using X-ray diffraction (XRD) and photoluminescence (PL), and the surface morphology was characterized by using atomic force microscope (AFM). The atomic H irradiation during the growth of GaInNAs was found to be very effective in improving the overall quality of epilayers. Further, we found that atomic H irradiation acts to suppress 3-dimensional islanded growth, and promote a 2-dimensional growth mode. Atomic H was also effective in passivating the active recombination defect centers. An improved PL characteristics was observed for GaInNAs grown on GaAs with atomic H at /spl sim/1.0 eV, measured at 77 K. In addition, we have also investigated the growth of GaInNAs films on Ge substrates, which is attractive for use in multi-junction III-V tandem solar cells.
Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: A review (2020)

This review presents an introduction to Raman scattering and describes the various Raman spectroscopy, Raman microscopy, and chemical imaging techniques that have demonstrated utility in biocolloidal self-assemblies, pharmaceutical drug delivery systems, and pulmonary research applications. Recent Raman applications to pharmaceutical aerosols in the context of pulmonary inhalation aerosol delivery are discussed. The “molecular fingerprint” insight that Raman applications provide includes molecular structure, drug-carrier/excipient interactions, intramolecular and intermolecular bonding, surface structure, surface and interfacial interactions, and the functional groups involved therein. The molecular, surface, and interfacial properties that Raman characterization can provide are particularly important in respirable pharmaceutical powders, as these particles possess a higher surface-area-to-volume ratio; hence, understanding the nature of these solid surfaces can enable their manipulation and tailoring for functionality at the nanometer level for targeted pulmonary delivery and deposition. Moreover, Raman mapping of aerosols at the micro- and nanometer level of resolution is achievable with new, sophisticated, commercially available Raman microspectroscopy techniques. This noninvasive, highly versatile analytical and imaging technique exhibits vast potential for in vitro and in vivo molecular investigations of pulmonary aerosol delivery, lung deposition, and pulmonary cellular drug uptake and disposition in unfixed living pulmonary cells.
Complete Genome Sequences of Bioluminescent Staphylococcus aureus Strains Xen31 and Xen36, Derived from Two Clinical Isolates (2023)

Here, we report complete genome sequences of two clinical isolates of Staphylococcus aureus, namely, Xen31 and Xen36, which have been genetically modified to express an optimized Photorhabdus luminescens luciferase operon. Xen31 and Xen36 are bioluminescent strains used widely for investigation of bacterial pathogenesis, drug discovery, and development of novel therapies.
Inpainting of local wavefront attributes using artificial intelligence (2019)

We propose a fast method to calculate local wavefront attributes for 3D prestack seismic data. First step is to compute attributes on a coarse regular or irregular grid in time and space using conventional approaches. Second step is very fast and efficient inpainting of the attributes in remaining locations by artificial intelligence utilizing a specially trained deep neural network. The method incorporates multi-parameter attributes using a special colouring scheme and allows estimation of multiple attributes simultaneously during one run. We demonstrate that inpainting of local wavefront attributes for nonlinear beamforming can greatly speed up prestack enhancement of 3D seismic data. Other applications such as velocity analysis or seismic tomography can be implemented using a similar approach. Presentation Date: Monday, September 16, 2019 Session Start Time: 1:50 PM Presentation Time: 2:40 PM Location: 221D Presentation Type: Oral
Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis. (1995)

To evaluate the effects of a p53-inducible gene WAF1/Cip1 on cell proliferation and apoptosis, a recombinant adenovirus vector (E1 minus) expressing WAF1/Cip1 cDNA (AdWAF1) was constructed and compared with a previously studied recombinant adenovirus vector expressing wild-type p53 (AdWTp53). Infection of normal and tumor cells of lung and mammary epithelial origin with AdWAF1 resulted in high levels of WAF1/Cip1 gene expression, which was comparable to that induced by AdWTp53. AdWAF1 and AdWTp53 inhibited growth of all cells studied; tumor cells devoid of endogenous p53 (H-358) or cells expressing endogenous mutant p53 (MDA-MB-231) were more sensitive to the inhibitory effect than tumor (MCF-7) or normal mammary epithelial cells expressing endogenous wild-type p53. Cell cycle analysis of AdWTp53-infected cells indicated a decline in the cell number in S phase and a significant increase in cell number in G2-M phase. AdWAF1 infection also led to a decline in the percentage of cells in S phase and a significant accumulation of cells in G1. AdWAF1 failed to induce apoptosis in any of the cells tested. In contrast, AdWTp53 induced apoptosis in H-358 and in MDA-MB-231 cells. These data suggest that AdWTp53-mediated WAF1/Cip1 induction and cytotoxicity are likely to be associated with WAF1/Cip1-mediated cell cycle arrest. However, because overexpression of WAF1/Cip1 protein failed to induce apoptosis, AdWTp53 effects on apoptosis apparently require cellular factors in addition to WAF1/Cip1 induction.
Synthesis, antifertility activity, and protein binding affinity of 7(8 .fwdarw. 11.alpha.)abeo steroids (1977)

A series of 7(8 leads to 11 alpha)abeo steroids was synthesized by a modification of the previously described total synthesis of this class of compounds and evaluated for biological activity. In general, there was a marked reduction in the relative binding affinities of these compounds for the rabbit uterus estrogen and progestin receptor proteins. None of the compounds which were subjected to uterotropic, antiuterotropic, postcoital, progestational, antiprogestational, or antiandrogenic assays showed any significant activity.
Sensitivity of Hybrid NEP-Chemical Vehicle Mass to Assumptions for Crewed Opposition-Class Mars Missions (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-3612.vid This research illustrates the impact of different technology choices and their associated performance on overall sizing for a hybrid Nuclear Electric Propulsion (NEP) and chemical crewed Mars transportation vehicle. A set of models for the trajectory and vehicle mass, power system specific mass (alpha), and power conversion performance enable the analysis. Vehicle mass required to close the mission is calculated as a function of alpha and specific impulse (Isp) for multiple choices of high-level assumptions including system alpha vs. power scaling and electric thruster type. System alpha is built up and compared for multiple cases of technology assumptions. A Brayton cycle model is used to illustrate the alpha sensitivities to assumptions in cycle design such as peak operating temperature and component performance. The analysis illustrates how technology performance sensitivities affect the alpha and thus vehicle sizing for a range of mission and technology assumptions.
Electromagnetic Nonreciprocity Using Electron Beam in a Waveguide (2020)

We theoretically show how the Lorentz reciprocity can be broken via inter action of electron beams with electromagnetic waves in cylindrical waveguides. Salient features such as the operating frequency range and nonreciprocity’s strength are discussed.
Winners of the 2017 MTT-S Undergraduate/Pregraduate Scholarships [Education News] (2018)

Eight extraordinary students were awarded an IEEE Microwave Theory and Techniques Society (MTT-S) undergraduate/pre-graduate scholarship for 2017. Scholarship winners were selected based on two calls for nominees: one in October 2016 to select the spring 2017 awardees and one in April 2017 to select the fall 2017 awardees. Every application was evaluated by three reviewers, each an esteemed MTT-S member working in either academia or industry (or both). The MTT-S Education Committee highly appreciates the valuable assistance and feedback of these reviewers. At the same time, we thank university staff for encouraging students to participate in this program, taking their first steps toward generating research in the RF and microwaves field. Project descriptions and awardee biographies are presented.
The results analysis of using MIGME-RRC methodology for software process improvement (2011)

Software process improvement is an obvious and logical way to address the increasing need to be competitive in the software industry. Consequently, software industry is more and more concerned about software process improvement (SPI). However, even when many organizations are motivated to improve their software processes, very few know how best to do so. Therefore, introducing software process improvement has been a path full of obstacles, leaving those who are involved in the improvement frustrated and more convinced than ever that they must continue doing their work as before. This paper shows the results analysis of implementing a software process improvement in the project management processes of fourth offices at a multinational organization. The process improvement was done by using a methodology which implements a smooth and continuous process improvement through the use of a multi-model environment as a reference model.
Book Reviews: Topics in Current Chemistry. Vol 105. Organic Chemistry (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBook Reviews: Topics in Current Chemistry. Vol 105. Organic ChemistryIwao OjimaCite this: Organometallics 1983, 2, 7, 941Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a038https://doi.org/10.1021/om50001a038research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hinge-Motion Binding Proteins: Unraveling Their Analytical Potential (2006)

ADVERTISEMENT RETURN TO ISSUEPREVFEATURENEXTHinge-Motion Binding Proteins: Unraveling Their Analytical PotentialElizabeth A. Moschou, Leonidas G. Bachas, Sylvia Daunert, and Sapna K. DeoCite this: Anal. Chem. 2006, 78, 19, 6692–6700Publication Date (Web):October 1, 2006Publication History Published online1 October 2006Published inissue 1 October 2006https://doi.org/10.1021/ac069464rRIGHTS & PERMISSIONSArticle Views862Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (370 KB) Get e-Alerts Get e-Alerts
Production of Antibodies against Multipass Membrane Proteins Expressed in Human Tumor Cells Using Dendritic Cell Immunization (2009)

Antibody mediated therapeutic strategies against human malignant tumors have been widely authorized and clinically applied to cancer patients. In order to develop methods to generate antibodies reactive to the extracellular domains of multipass plasma membrane proteins specifically expressed in malignant tumors, we examined the use of dendritic cells (DCs) for immunization. DCs were transduced with genes encoding the human six transmembrane epithelial antigen of prostate 1 (STEAP1), STEAP4, and seven transmembrane prostate specific G-protein coupled receptor (PSGR). Mice were immunized with these DCs and followed by repeated booster immunization with plasmids expressing each protein. The immunized mice produced significant amounts of antibodies against these proteins. Our results suggest that DC immunization is an effective method to produce antibodies reactive to extracellular regions of plasma membrane proteins with multiple-transmembrane domains, and may be useful to develop antibody mediated antitumor therapies.
Silica Monolith for the Removal of Pollutants from Gas and Aqueous Phases (2021)

This study focused on the application of mesoporous silica monoliths for the removal of organic pollutants. The physico-chemical textural and surface properties of the monoliths were investigated. The homogeneity of the textural properties along the entire length of the monoliths was assessed, as well as the reproducibility of the synthesis method. The adsorption properties of the monoliths for gaseous toluene, as a model of Volatile Organic Compounds (VOCs), were evaluated and compared to those of a reference meso-structured silica powder (MCM-41) of commercial origin. Silica monoliths adsorbed comparable amounts of toluene with respect to MCM-41, with better performances at low pressure. Finally, considering their potential application in water phase, the adsorption properties of monoliths toward Rhodamine B, selected as a model molecule of water soluble pollutants, were studied together with their stability in water. After 24 h of contact, the silica monoliths were able to adsorb up to the 70% of 1.5 × 10<sup>-2</sup> mM Rhodamine B in water solution.
Monitoring the thermally induced structural transitions of collagen by use of second-harmonic generation microscopy (2005)

The thermal disruption of collagen I in rat tail tendon is investigated with second-harmonic generation (SHG) microscopy. We investigate its effects on SHG images and intensity in the temperature range 25 degrees-60 degrees C. We find that the SHG signal decreases rapidly starting at 45 degrees C. However, SHG imaging reveals that breakage of collagen fibers is not evident until 57 degrees C and worsens with increasing temperature. At 57 degrees C, structures of both molten and fibrous collagen exist, and the disruption of collagen appears to be complete at 60 degrees C. Our results suggest that, in addition to intensity measurement, SHG imaging is necessary for monitoring details of thermally induced changes in collagen structures in biomedical applications.