gebhart/patrepeval huggingface dataset:
Co-conception matérielle et logicielle pour du traitement de trafic flexible au-delà du terabit par seconde (2018)

La fiabilité et la sécurité des réseaux de communication nécessitent des composants efficaces pour analyser finement le trafic de données. La diversification des services ainsi que l'augmentation des débits obligent les systèmes d'analyse à être plus performants pour gérer des débits de plusieurs centaines, voire milliers de Gigabits par seconde. Les solutions logicielles communément utilisées offrent une flexibilité et une accessibilité bienvenues pour les opérateurs du réseau mais ne suffisent plus pour répondre à ces fortes contraintes dans de nombreux cas critiques.Cette thèse étudie des solutions architecturales reposant sur des puces programmables de type Field-Programmable Gate Array (FPGA) qui allient puissance de calcul et flexibilité de traitement. Des cartes équipées de telles puces sont intégrées dans un flot de traitement commun logiciel/matériel afin de compenser les lacunes de chaque élément. Les composants du réseau développés avec cette approche innovante garantissent un traitement exhaustif des paquets circulant sur les liens physiques tout en conservant la flexibilité des solutions logicielles conventionnelles, ce qui est unique dans l'état de l'art.Cette approche est validée par la conception et l'implémentation d'une architecture de traitement de paquets flexible sur FPGA. Celle-ci peut traiter n'importe quel type de paquet au coût d'un faible surplus de consommation de ressources. Elle est de plus complètement paramétrable à partir du logiciel. La solution proposée permet ainsi un usage transparent de la puissance d'un accélérateur matériel par un ingénieur réseau sans nécessiter de compétence préalable en conception de circuits numériques.
Brief Psychotic Disorder After Abrupt Withdrawal of Hydroxyzine Hydrochloride (2014)

Bock, Oliver MD; Wenzel, Claudia MD; Herrmann, Julian MD; Dillo, Wolfgang MD; Poehnert, Daniel MD, PhD; Bleich, Stefan MD; Frieling, Helge MD Author Information
Radiolucency and Pseudoarthrosis after 4 Year Follow-up on a Minimally Invasive Presacral Approach (2011)

20 patients (48.3 y/o, 29-70 range) with DDD at L4-L5 and L5-S1 underwent an axial lumbosacral minimal invasive fusion, which was performed through a 14 mm access cannula using an innovative minimally invasive axial presacral approach coupled with bone graft and posterior percutaneous pedicle screws. Analysis consisted on X-ray and CT evaluation by an independent radiologist and two spine surgeons. VAS and ODI clinical assessments were collected at preop and postop follow-up points. Learning Objectives
Hydrogenolysis of Palladium(II) Hydroxide and Methoxide Pincer Complexes (2009)

Hydrogenolysis reactions of palladium(II) hydroxide and methoxide complexes to form water and methanol, respectively, and the corresponding palladium(II) hydride are reported. In the presence of water, 1 was found to exist in solution as a water-bridged dimer; however, kinetic studies suggest the reaction of 1 and H(2) proceeds exclusively through the hydroxide monomer to form the palladium(II) hydride and water. Computational studies suggest a four-center intramolecular proton transfer as opposed to an oxidative addition/reductive elimination pathway.
Supplementary Figure S2 from Immunologic assessment of tumors from a race-matched military cohort identifies mast cell depletion as a marker of prostate cancer progression (2023)

&lt;p&gt;Supplementary Figure S2 shows non-significant relative cell type scores by race.&lt;/p&gt;
NLRP3 Protein Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1β (2014)

Background: The role of NLRP3 inflammasomes in hyperoxic acute lung injury (HALI) remains unclear. Results: NLRP3 deficiency exacerbated lethality and diminished Stat3 activation caused by inflammatory cells in a murine HALI model. Conclusion: NLRP3 regulates Stat3 activation by affecting inflammatory cell infiltration independent of IL-1. Significance: These findings demonstrate the novel role of NLRP3 in Stat3-mediated protective effects against HALI. Supplemental oxygen inhalation is frequently used to treat severe respiratory failure; however, prolonged exposure to hyperoxia causes hyperoxic acute lung injury (HALI), which induces acute respiratory distress syndrome and leads to high mortality rates. Recent investigations suggest the possible role of NLRP3 inflammasomes, which regulate IL-1 production and lead to inflammatory responses, in the pathophysiology of HALI; however, their role is not fully understood. In this study, we investigated the role of NLRP3 inflammasomes in mice with HALI. Under hyperoxic conditions, NLRP3 / mice died at a higher rate compared with wild-type and IL-1 / mice, and there was no difference in IL-1 production in their lungs. Under hyperoxic conditions, the lungs of NLRP3 / mice exhibited reduced inflammatory responses, such as inflammatory cell infiltration and cytokine expression, as well as increased and decreased expression of MMP-9 and Bcl-2, respectively. NLRP3 / mice exhibited diminished expression and activation of Stat3, which regulates MMP-9 and Bcl-2, in addition to increased numbers of apoptotic alveolar epithelial cells. In vitro experiments revealed that alveolar macrophages and neutrophils promoted Stat3 activation in alveolar epithelial cells. Furthermore, NLRP3 deficiency impaired the migration of neutrophils and chemokine expression by macrophages. These findings demonstrate that NLRP3 regulates Stat3 signaling in alveolar epithelial cells by affecting macrophage and neutrophil function independent of IL-1 production and contributes to the pathophysiology of HALI.
Evaluation of macrophage cell membrane preparations for proteomics analysis (2007)

Evaluation of macrophage cell membrane preparations for proteomics analysis: E1–11 N. Caceres;M. Aerts;M. Mingeot-Leclercq;R. Wattiez;P. Tulkens;B. Devreese;F. Bambeke; The FEBS Journal
NMR spectra of pureC13diamond (1994)

NMR measurements on single crystals of pure $^{13}\mathrm{C}$ diamond are reported. The line shape is very sensitive to the orientation of the external magnetic field relative to the crystallographic axes, typical of dipolar line broadening. With the magnetic field oriented along the [110] direction, the line is broad and flat, whereas a more narrow, Gaussian shape is seen along [001]. For the [111] direction, a spectacular line splitting of 8.5 kHz is observed. For the sample studied, the spin-lattice relaxation time was about 15 s at room temperature and 140 s at 140 K. The spectra are interpreted by a simple model using dipolar interactions.
An integrated microdevice for high‐performance short tandem repeat genotyping (2009)

Short tandem repeat (STR) analysis provides genetic fingerprinting of individuals, and is considered as a powerful and indispensable technique for forensic human identification. However, the current state-of-the-art STR genotyping processes and instruments are labor intensive, expensive, time consuming, and lack portability. Micro-total-analysis systems or lab-on-a-chip platforms based on microfabrication technologies have the capability to miniaturize and integrate bioanalysis steps in a single format. Recent progress in microsystems has demonstrated their successful performance for the forensic STR typing with a reduced cost, high speed, and improved high throughput. The purpose of this review article is to highlight up-to-date work on advanced microdevices for high-throughput STR genotyping, and a portable integrated microsystem for on-site forensic DNA analysis.
The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells. (1998)

Mast cells are found frequently in close proximity to blood vessels, and endothelial cells are likely to be exposed to high concentrations of their granule mediators. We have investigated the proinflammatory actions of the major mast cell product tryptase on HUVEC. Addition of purified tryptase was found to stimulate thymidine incorporation, but induced little alteration in cell numbers, suggesting it is not a growth factor for HUVEC. Expression of ICAM-1, VCAM-1, and E-selectin was not altered following incubation with tryptase, but the potent granulocyte chemoattractant IL-8 was released in a dose-dependent fashion in response to physiologically relevant concentrations, with maximal levels in supernatants after 24 h. The actions of tryptase on HUVEC were inhibited by heat inactivation of the enzyme, or by preincubating with the protease inhibitors leupeptin or benzamidine, suggesting a requirement for an intact catalytic site. Reverse-transcription PCR analysis indicated up-regulation of mRNA for IL-8 as well as for IL-1 beta in response to tryptase or TNF-alpha. However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. Leukocyte accumulation in response to tryptase may be mediated in part through the selective secretion of IL-8 from endothelial cells.
TTP (1992)

In this paper we describe TTP, a fast and robust natural language parser which can analyze written text and generate regularized parse structures for sentences and phrases at the speed of approximately 0.5 sec/sentence, or 44 word per second. The parser is based on a wide coverage grammar for English, developed by the New York University's Linguistic String Project, and it uses the machine-readable version of the Oxford Advanced Learner's Dictionary as a source of its basic vocabulary. The parser operates on stochastically tagged text, and contains a powerful skip-and-fit recovery mechanism that allows it to deal with extra-grammatical input and to operate effectively under a severe time pressure. Empirical experiments, testing parser's speed and accuracy, were performed on several collections: a collection of technical abstracts (CACM-3204), a corpus of news messages (MUC-3), a selection from ACM Computer Library database, and a collection of Wall Street Journal articles, approximately 50 million words in total.
Biofabrication of 3D printed hydroxyapatite composite scaffolds for bone regeneration (2020)

Biofabrication has been adapted in engineering patient-specific biosynthetic grafts for bone regeneration. Herein, we developed a three-dimensional (3D) high-resolution, room-temperature printing approach to fabricate osteoconductive scaffolds using calcium phosphate cement (CPC). The non-aqueous CPC bioinks were composed of tetracalcium phosphate, dicalcium phosphate anhydrous, and Polyvinyl butyral (PVB) dissolved in either ethanol (EtOH) or tetrahydrofuran (THF). They were printed in an aqueous sodium phosphate bath, which performs as a hardening accelerator for hydroxyapatite formation and as a retainer for 3D microstructure. The PVB solvents, EtOH or THF, affected differently the slurry rheological properties, scaffold microstructure, mechanical properties, and osteoconductivity. Our proposed approach overcomes limitations of conventional fabrication methods, which require high-temperature (>50 °C), low-resolution (>400 μm) printing with an inadequate amount of large ceramic particles (>35 μm). This proof-of-concept study opens venues in engineering high-resolution, implantable, and osteoconductive scaffolds with predetermined properties for bone regeneration.
NFC Mobile Parlor Games Enabling Direct Player to Player Interaction (2011)

Whilst there has been considerable research focus on the user experience of using NFC enabled mobile phones interacting with tags or objects, the ability to perform peer to peer contact has been given little consideration and is often dismissed as being only useful for setting up a connection or transferring business cards. In this research, we present two games that show how the intimate nature of this interaction can successfully be used as a game mechanic for social mobile games, where it is specifically designed to create a shared social experience and generating a near physical interaction between players. In particular, the two games presented use NFC within designs inspired by 19th century parlor games to illustrate how mobile games can benefit from the success console games such as Guitar Hero which move the focus of the player group from screen space to player space and allow a more intimate interaction and approach.
Evaluation of damage induced by electron-beam irradiation to metal-oxide semicondoctor gate pattern and method for damage-free inspection (2007)

We analyze the electron-irradiation damage induced in wafers by scanning electron microscope (SEM) inspection, which uses SEM images of voltage contrast formed by the charges on the pattern. The effects of electron-beam energy and charging on a metal-oxide semiconductor (MOS) capacitor are studied. We find that the higher energy electron beam, whose electron range is larger than the thickness of the gate electrode, creates traps at the interface between the silicon substrate and the gate dielectric. The flat-band voltage is shifted by the created traps. Although these traps are created by the transmission of the electron beam into the dielectric, they are not created only by charging on the gate electrode; neither is an oxide fixed charge created in the MOS capacitor. Accordingly, for damage-free inspection of MOS devices, the electron-beam energy should be low enough that the electron range is smaller than the thickness of the gate electrode. On the other hand, the flat-band voltage does not shift, owing to charging on the pattern surface during the electron irradiation. However, the gate dielectric is broken down by charging on the gate electrode at high voltage. Accordingly, for damage-free inspection, the charging voltage should be controlled so as not to break down the gate dielectric.
Hydrothermal synthesis of inorganic–organic hybrid gadolinium hydroxide nanoclusters with controlled size and morphology (2013)

A series of gadolinium hydroxide [Gd(OH)3] nanoclusters having different morphologies was synthesized in the presence of 3,4-dihydroxy hydrocinnamic acid (DHCA), an organic modifier, under subcritical water conditions. These well-shaped Gd(OH)3 clusters are composed of many nanorods in a parallel orientation, rather than a disordered aggregation of nanorods, which are linked together by organic DHCA molecules. Here DHCA works as an inter-linker to form these cluster-like structures through coordination bonds. All samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and SQUID magnetometry. We investigated the effect of the concentrations of DHCA and KOH on the size and morphology of the Gd(OH)3 clusters. Their possible formation mechanism is also briefly discussed.
A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients (2019)

Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascular risk. The clearance of these uremic toxins using current hemodialysis techniques is limited due to their hydrophobicity and their high binding affinity to plasma proteins. Adsorber techniques may be an appropriate alternative to increase hydrophobic uremic toxin removal. We developed an extracorporeal, whole-blood bifunctional adsorber particle consisting of a porous, activated charcoal core with a hydrophilic polyvinylpyrrolidone surface coating. The adsorption capacity was quantified using analytical chromatography after perfusion of the particles with an albumin solution or blood, each containing mixtures of hydrophobic uremic toxins. A time-dependent increase in hydrophobic uremic toxin adsorption was depicted and all toxins showed a high binding affinity to the adsorber particles. Further, the particle showed a sufficient hemocompatibility without significant effects on complement component 5a, thrombin-antithrombin III complex, or thrombocyte concentration in blood in vitro, although leukocyte counts were slightly reduced. In conclusion, the bifunctional adsorber particle with cross-linked polyvinylpyrrolidone coating showed a high adsorption capacity without adverse effects on hemocompatibility in vitro. Thus, it may be an interesting candidate for further in vivo studies with the aim to increase the efficiency of conventional dialysis techniques.
Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin (2013)

These studies show that although biologically different, BMP signaling is growth promoting in cancer cells expressing Oct4 or nestin. Inhibition of BMP signaling decreases expression of Id proteins and suppresses growth of cancer cells expressing Oct4 or Nestin. Small molecule antagonists of the BMP type I receptors represent potential novel drugs to target the population of cancer cells expressing stem cell markers.
Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin (2020)

Increase in blood-brain barrier (BBB) permeability is a crucial step in neuroinflammatory processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed on cerebral endothelial cells forming the BBB, regulate immune cell infiltration across this barrier in the mouse. Here, we describe the mechanism responsible for the action of NMDARs on BBB permeabilization. We report that mouse CNS endothelial NMDARs display the regulatory GluN3A subunit. This composition confers to NMDARs' unconventional properties: these receptors do not induce Ca<sup>2+</sup> influx but rather show nonionotropic properties. In inflammatory conditions, costimulation of human brain endothelial cells by NMDA agonists (NMDA or glycine) and the serine protease tissue plasminogen activator, previously shown to potentiate NMDAR activity, induces metabotropic signaling via the Rho/ROCK pathway. This pathway leads to an increase in permeability via phosphorylation of myosin light chain and subsequent shrinkage of human brain endothelial cells. Together, these data draw a link between NMDARs and the cytoskeleton in brain endothelial cells that regulates BBB permeability in inflammatory conditions.<b>SIGNIFICANCE STATEMENT</b> The authors describe how NMDARs expressed on endothelial cells regulate blood-brain barrier function via myosin light chain phosphorylation and increase in permeability. They report that these non-neuronal NMDARs display distinct structural, functional, and pharmacological features than their neuronal counterparts.
PW01-012 – Canakinumab in patients with FMF (2013)

In a recent pilot study, it was reported that Canakinumab reduced the frequency of attacks in 9 patients with Familial Mediterranean Fever (FMF) resistant to colchicine with no apparent side effects [1].
A synthetic route to the tricarbonyl region of FK-506 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA synthetic route to the tricarbonyl region of FK-506Melissa Egbertson and Samuel J. DanishefskyCite this: J. Org. Chem. 1989, 54, 1, 11–12Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jo00262a005https://doi.org/10.1021/jo00262a005research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Preparation of Viable Isolated Bovine Parathyroid Cells (1976)

A method is described for the preparation of isolated bovine parathyroid cells. Fresh, minced bovine parathyroid tissue is incubated with 2 mg/ml collagenase and 50 mug/ml DNAse for 1 h at 37 C with periodic pipetting. Parthyroid cells are separated from contaminating fat cells and red cells by low speed centrifugation. The resulting cell preparation is indistinguishable from parathyroid cells in intact bovine glands by light and electron microscopy. Hormone release is linear for at least 3 h at both high (2.0 mM) and low (0.5 mM) calcium concentrations and is inversely proportional to divalent cation concentration between 0.3 mM and 1.0 mM calcium as been observed previously both in vivo and in vitro. As in previous studies, hormone release is also stimulated up to 2-fold by 10(6) M (-)isoproterenol, an effect blocked by 10(-6)M (-)propranolol, suggesting a beta-adrenergic effect. Such a cell preparation should be useful for studying hormone binding and effects on cyclic nudleotides and cellular transport phenomena in both normal amd abnormal tissue.
Nonlinear and Linear Shielding of Rare-Earth Crystal-Field Interactions (1965)

It was shown previously that significant nonlinear shielding of the rare-earth electrostatic crystalline-field interactions may occur, and hence that the standard parametrization scheme used to determine the crystalfield parameters, ${{V}_{L}}^{M}={{A}_{L}}^{M}〈{r}^{L}〉$, was questionable. These nonlinear effects arise from the same distortions of the closed shells in rare-earth ions which produce the (larger) linear shielding of the crystal field ${V}_{\mathrm{c}}$. In this paper, both nonlinear and linear shielding effects have been investigated for the rare-earth ions ${\mathrm{Ce}}^{3+}$, and ${\mathrm{Tb}}^{3+}$ through ${\mathrm{Yb}}^{3+}$ inclusive. The method of single substituted configurations is employed and is shown to avoid the difficulties associated with the traditional single-determinant perturbation-theory approach previously used exclusively by various authors. Results based on both methods are given and compared; significant differences in linear-shielding predictions are found to be introduced by the inexact traditional approach. Calculations for the nonlinear $5p\ensuremath{\rightarrow}4f$ effects have been done, and results displayed, as a function of the strength of ${V}_{\mathrm{c}}$ (based on the point-charge model). The relevance of these effects to experiment is examined qualitatively.