gebhart/patrepeval huggingface dataset:
IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection (2019)

Chronic infection and cancer are associated with suppressed T cell responses in the presence of cognate antigen. Recent work identified memory-like CXCR5<sup>+</sup> TCF1<sup>+</sup> CD8<sup>+</sup> T cells that sustain T cell responses during persistent infection and proliferate upon anti-PD1 treatment. Approaches to expand these cells are sought. We show that blockade of interferon type 1 (IFN-I) receptor leads to CXCR5<sup>+</sup> CD8<sup>+</sup> T cell expansion in an IL-27- and STAT1-dependent manner. IFNAR1 blockade promoted accelerated cell division and retention of TCF1 in virus-specific CD8<sup>+</sup> T cells. We found that CD8<sup>+</sup> T cell-intrinsic IL-27 signaling safeguards the ability of TCF1<sup>hi</sup> cells to maintain proliferation and avoid terminal differentiation or programmed cell death. Mechanistically, IL-27 endowed rapidly dividing cells with IRF1, a transcription factor that was required for sustained division in a cell-intrinsic manner. These findings reveal that IL-27 opposes IFN-I to uncouple effector differentiation from cell division and suggest that IL-27 signaling could be exploited to augment self-renewing T cells in chronic infections and cancer.
Transfer Across Random versus Deterministic Fractal Interfaces (2000)

A numerical study of the transfer across random fractal surfaces shows that their responses are very close to the response of deterministic model geometries with the same fractal dimension. The simulations of several interfaces with prefractal geometries show that, within very good approximation, the flux depends only on a few characteristic features of the interface geometry: the lower and higher cutoffs and the fractal dimension. Although the active zones are different for different geometries, the electrode responses are very nearly the same. In that sense, the fractal dimension is the essential "universal" exponent which determines the net transfer.
Localised Stress Measurements in Composite Laminates Using a Raman Stress Sensor (1995)

A new remote laser Raman stress/ strain sensor for localised measurements in polymer based composites, has been developed and tested. Measurements can be conducted in reinforcing fibres near the surface of laminates. For measurements in the bulk of composites, the exciting laser light has to be transported to the reinforcing fibres via an embedded fibre optic cable. The backscattered light is transmitted through the same fibre optic and is sent to the Raman spectrometer for analysis. The effect of the direction of the fibre optic cable with respect to the axis of the reinforcing fibres is examined. Finally, the relationships between the local fibre stress or strain obtained from the Raman sensor and the far field stress or strain measured conventionally, are established.
Effect of prophylactic digitalization on the development of myocardial hypertrophy (1977)

The effect of prophylactic digitalization on the development of left ventricular hypertrophy was studied in adult rats. Digitoxin, 0.1 mg/100 g body wt or solvent was given daily for 1 wk prior to either aortic constriction or sham operation and was continued until the animals were killed, either 1 or 4 wk after surgery. A hemodynamic study was done in those animals killed 1 wk after surgery; hearts of all animals were examined for evidence of myocardial hypertrophy. Constriction of the ascending aorta had no significant effect on cardiac output but did reduce peak flow velocity and flow acceleration. An increase in left ventricular mass, RNA, and hydroxyproline was found in the animals with aortic constriction. Digitoxin treatment did not alter peak flow velocity or flow acceleration, but did significantly increase isovolumic (dP/dt)P-1. Digitoxin had no effect on body weight, heart weight, RNA, or hydroxyproline in either the sham-operated animals or in the animals with aortic constriction. Therefore, despite plasma digitoxin levels sufficient to affect myocardial contractility, left ventricular hypertrophy still developed after aortic constriction.
Abstract 18343: Antisynthetase Syndrome-Associated Myocarditis (2014)

Background: The antisynthetase (AS) syndrome is characterized by fever, non-erosive arthritis, inflammatory myopathy, interstitial lung disease, cutaneous involvement, and antibody specificity. Cardiac involvement is extremely rare; we present one of two cases of AS syndrome-associated myocarditis from our institution. Clinical Case: A 51 year old woman with history of inflammatory arthritis and hypothyroidism presented with 6 months of increasing fatigue, bilateral proximal muscle weakness, leg edema, dyspnea, and orthopnea. Physical examination revealed a Caucasian woman, markedly dyspneic while speaking, with signs of acute decompensated heart failure (HF) including elevated jugular venous pulse, bilateral rales, S3 gallop, and massive peripheral edema with bilateral proximal upper and lower extremity weakness. Diagnostic Testing: Her muscle weakness was concerning for myopathy along with new HF symptoms. Laboratory studies revealed elevations of serum creatine kinase, aldolase, and cardiac troponin I. Thyroid stimulating hormone and free T4 were consistent with subclinical hypothyroidism. MRI and electromyography of the lower extremities and skeletal muscle biopsy were consistent with myositis. Anti-Jo1 antibody was positive, confirming the diagnosis of AS syndrome. Electrocardiogram showed sinus rhythm and low-voltages in all leads. Echocardiography showed severely depressed biventricular function, left ventricular (LV) ejection fraction of 10-15%, normal LV cavity size and wall thickness. Cardiac MRI and endomyocardial biopsy revealed active myocarditis. She received pulse dose corticosteroid therapy, intravenous furosemide, inotropic therapy, and hemofiltration therapy for renal failure. She was discharged home on intravenous dobutamine palliative therapy. Two months later, she presented in cardiogenic shock, failed intensive medical therapy, and died after a cardiac arrest. Conclusions: AS syndrome is a rare entity not typically associated with cardiac involvement. We report one of only two known cases of AS syndrome-associated myocarditis, to our knowledge. Based on these observations, we suggest that myocarditis be considered and evaluated for in patients with AS syndrome presenting with HF.
Development of Bio-chemical Sensor System Integrated with Blood Extraction Device (2007)

The fabrication of a blood extraction device integrated with an electrolyte-monitoring system is reported in this paper. The device has advantages in precise controlled dosage of blood extracted including the slightly damaged blood vessels and nervous system. Main components of the portable system are; the blood extraction device and electrolyte-monitoring system. The monitoring system consists of ISFET (ion selective field effect transistor) for measuring the concentration level of minerals in blood. In this work, the authors measured the level of 3 ions; Na <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> , K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> and Cl <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> . The 100 hollow-microneedles fabricated by synchrotron radiation deep X-ray lithography through PCT (plane-pattern to cross-section transfer) technique were revealed in 5times5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> area. The total size of the blood extraction device is 2times2times2 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . The package is made from an acrylic socket consisting of microneedle array block, ion-sensors block, blood and reference reservoirs. ISFET was connected to an electrical circuit for monitoring the potential different.
Comparison of isoelectronic aluminum-nitrogen and silicon-carbon double bonds using valence bond methods (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of isoelectronic aluminum-nitrogen and silicon-carbon double bonds using valence bond methodsMary M. Lynam, Leonard V. Interrante, Charles H. Patterson, and Richard P. MessmerCite this: Inorg. Chem. 1991, 30, 8, 1918–1922Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ic00008a044https://doi.org/10.1021/ic00008a044research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Agitation and aggression in people with Alzheimer's disease (2013)

Currently, the best approach for managing these symptoms is within a framework of good practice that promotes prevention, monitoring and the use of nonpharmacological alternatives, with judicious short-term use of antipsychotics, when appropriate.
P3‐284: Ethanol effect over Aβ aggregates and toxicity reduction in cell cultures (2010)

The pathology of Alzheimer's disease (AD) involves loss of superior cognitive functions. It has been recently acknowledged that the toxic agents in AD are soluble aggregates. Prospective clinical studies have shown that moderate alcohol intake may reduce the probability of developing neurodegenerative diseases. In this work we observed the toxic effects exhibited by Aβ peptides (Aβ) aggregates in HEK and PC-12 cell cultures compared with Aβ aggregates formed in the presence of milimolar ethanol concentrations. Our findings show that already 5 μM of Aβ concentration reduce the cell culture viability in both types. In contrast, these alterations appear to be blocked in presence of Aβ aggregates formed with 10 mM ethanol. Besides, we suggest that ultrastructural modifications of the aggregates could furnish an explanation of the reduced toxicity of the Aβ over the cultured cells. By simulating this protein in an ethanol environment we observe that the dimer of the Aβ is less stable, favoring formation of new non-toxic structures. These evidences support the idea that ethanol protect cell viability from the effects of the Aβ aggregates, thus furnishing a possible explanation for the clinic effects described in AD. Moreover these techniques allow studying new molecules with similar effects and searching new mechanism of protection.
Early detection of the low dose of Lead exposure prevents mental disorders using non-invasive fluorescence and multi-omics (2022)

Lead poisoning is an epidemic that can affect anyone. Lead toxicity most commonly affects children and causes neurodevelopmental problems chronically. Lead is a heavy metal that alters calcium metabolism and deactivates enzymes essential in activating heme in the blood. Heme is an integral part of homeostasis and body defense in the shuttling of oxygen throughout the tissues, most notably the brain metabolism. The lack of oxygen throughout the brain slows down brain development (e.g., Neuronal cell migration, polarization, neuronal cell differentiation) and leads to lower IQs, learning disabilities, and lifelong ailments. The most common form of lead exposure comes from lead-based paint, toys, cosmetic materials, other household materials, various environments, and occupational pollutants. The current biomarkers used for lead toxicity successfully detect current lead levels in the blood but are not excellent at determining duration. Bone-Pb allows for the detection of lead toxicity duration, but it is not widely accepted throughout the United States. Significant limitations exist because all biomarkers test for lead poisoning after it has already happened which makes it challenging to prevent lead exposure in a clinical setting. Prevention needs to happen at the governmental and, more importantly at the individual levels. The focus of this study is on lead toxicity and prevention followed by reducing risk and improvement of detection utilized tools-driven molecular-based assessment along with visual imaging technique. It examines how lead finds its way into the human body for storage or metabolomic by-products. Identifying the risks of exposure would inform the mechanisms that can be employed to prevent further exposure and toxicity in other organs or intervene with metabolism or biotransformation. It predicts the potential counteract mechanisms through which lead affects the health of pregnant mothers, or interaction between prenatal, or the unborn, and post-natal status, different stages of developmental, and post-menopausal women. The study outlines the various ways of detecting the presence of low levels of lead in the blood and bones using non-invasive fluorescence combined with multidimensional omics such as metabolomic and proteomic by which early detection of organ dysfunction can be used to monitor Ca2+ metabolism in the cell or tissue/organ level before the onset of disease
Constitutive parameter retrieval for uniaxial metamaterials with spatial dispersion (2016)

We propose a constitutive parameter retrieval approach in which all electromagnetic parameters of the medium are obtained taking spatial dispersion into account. Moreover, the constraint on nonmagnetic metal/dielectric metamaterials is relaxed. This procedure is applied to metal/dielectric stacks in order to address the effects of the layer thickness, layer number, and material choice on the spatial dispersion. The results demonstrate that the investigated metal/dielectric stacks have a clear magnetic response, particularly for thicker layers. Moreover, this magnetic response is also a function of the magnitude of the $|{k}_{x}/{k}_{0}|$ ratio, where ${k}_{x}$ is the wave vector parallel to the interface planes and ${k}_{0}$ is the free-space wave number. We demonstrate that the real part of the dispersion curve flattens out (with a corresponding large imaginary part being present) as a result of the absence of propagating modes inside the metamaterial. This flat region is strongly dependent on the thickness of the layers and is a direct manifestation of spatial dispersion. Using this parameter retrieval method we calculate the Purcell factor for Rb atoms 10 nm above the surface of a ${\mathrm{Ag}/\mathrm{TiO}}_{2}$ stack with two filling factors $\ensuremath{\rho}$ $[\ensuremath{\rho}=l/(l+d)$ with $l$ and $d$ as the metal and dielectric layer thicknesses, respectively], $\ensuremath{\rho}=0.3$ and $\ensuremath{\rho}=0.5$, and having $N=13$ layers, for the emission wavelengths of 435 nm and 785 nm. Results are then compared with three different approaches, and we show that if spatial dispersion is not properly taken into account, then the Purcell factor is overestimated. Our approach shows excellent agreement with Purcell factors obtained from precise and accurate numerical calculations of the corresponding nonhomogenized structures.
Photonic trimming of quantum emitters via direct fabrication of metallic nanofeatures (2018)

In this paper, we demonstrate the control of the emission of a GaAs quantum dot embedded in a GaAs/AlGaAs nanowire by the post-fabrication of a plasmonic grating on its surface. Using a direct electron beam-induced deposition of Pt nanowires, we demonstrate an enhancement of the emission efficiency for the polarization parallel to the nanowires of 45%, with a 17% reduction in the photon lifetime. We believe that these results will help establish a new hybrid nanophotonic platform for efficient single photon sources.
The Organisation of Jewish Burials in ancient Rome in the Light of Evidence from Palestine and the Diaspora (1994)

A partir de l'etude des sepultures rupestres des Juifs de Palestine et de la Diaspora, depuis les temps les plus anciens jusqu'au 3eme siecle apr. J.-C., l'auteur discute les 2 hypotheses emises a propos de l'organisation des sepultures des catacombes de la communaute juive de l'ancienne Rome: selon les uns, celles-ci sont regies par un principe unique pour l'ensemble de la communaute, alors que l'autre courant de pensee penche pour une organisation differente suivant chaque congregation.
Erythrocyte‐mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease (2001)

Human erythrocytes from ten patients with chronic obstructive pulmonary disease (COPD) were loaded with increasing amounts of dexamethasone 21-phosphate and were re-infused into the original donors. Drug-loaded erythrocytes acted as circulating bioreactors, converting the non-diffusible dexamethasone 21-phosphate into the diffusible dexamethasone. Pharmacokinetic analyses on these patients showed that a single administration of drug-loaded erythrocytes was able to maintain detectable dexamethasone concentrations in blood for up to seven days. This continuous release of dexamethasone was paralleled by the suspension of beta2-agonist and oral corticosteroid treatments by all of the patients. Thus dexamethasone 21-phosphate-loaded erythrocytes are safe carriers for corticosteroid analogues and are a useful alternative to frequent oral or inhaled drugs in elderly patients with COPD.
Non-destructive fault isolation in through-silicon interposer based system in package (2020)

The importance of IC packaging technologies within semiconductor manufacturing has increased dramatically over the last decade. Advanced packaging, including 2.5D ICs, is becoming more widely used due to its integrated functionality. However, due to the complexity of the advanced package architectures, it also poses challenges in localizing the defect, which is required for the successful investigation of faults. In this paper, an approach to accurately localize the failures in 2.5-D integrated system-in-package is presented. Two different case studies are discussed to demonstrate fault isolation, the first one with a short defect at the die, and the second one having an open defect at the substrate. The proposed method to locate faults rapidly with an accuracy of less than <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$10\mu\mathrm{m}$</tex> will provide an effective solution for investigating yield-loss in advanced packages.
Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. (1994)

A cDNA encoding human glutamine phosphoribosylpyrophosphate amidotransferase for step one in de novo purine nucleotide synthesis was cloned, sequenced, and expressed in Chinese hamster ovary cells to yield functional enzyme. Enzyme function was dependent upon removal of an 11-amino-acid propeptide. A mutant enzyme having three propeptide amino acid replacements was not processed and was not active. The human genes GPAT, encoding the amidotransferase, and AIRC, encoding a bifunctional enzyme for steps six and seven in the pathway, were cloned and characterized. GPAT and AIRC are closely linked and divergently transcribed from an intergenic region of approximately 625 base pairs. Expression of a luciferase reporter from the GPAT promoter was approximately 3-4-fold higher than from the AIRC promoter. The GPAT gene was mapped to the q12 region of chromosome 4.
Qantitative changes in the cellular population of the growth plate of triamcinolone-treated mice (1977)

Triamcinolone-induced changes in the number of cartilage within the proximal growth plate of the humerus were determined in ICR male mice. It was found that pharmacological doses of corticosteroid hormone possess a direct inhibitory effect upon the proliferative activity of young cartilage cells and thereby adversely affect the growth potential of this growth center. Concomitantly, the activity of chondroclasts also appears to be depressed, thus resulting in a decreased rate of cartilage reorption followed by a slight increase in the number of hypertrophic chondrocytes. It therefore appears that systemic treatment with corticosteroid hormones inhibits the renewal of cartilage cells in the epiphyseal plate, leading to an accelerated 'aging' of this growth center with subsequent impairment of long bone growth.
Surface states and dipoles on Si(111)1×1:Na (1986)

A theoretical study of the interface formed by adsorption of one monolayer of Na on the Si(111) surface is presented. The equilibrium structure is predicted by minimizing the energy using the first principles pseudopotential method and local density approximation. The dispersion of the Na induced surface states, and the dipole resulting from charge transfer from the Na 3s orbitals into these surface states is calculated. The ionization potential of the overlayer system is predicted to be 2.1 eV.
Hybrid rate control for IEEE 802.11 (2004)

Streaming multimedia content in real-time over a wireless link is a challenging task because of the rapid fluctuations in link conditions that can occur due to movement, interference, and so on. The popular IEEE 802.11 standard includes low-level tuning parameters like the transmission rate. Standard device drivers for today's wireless products are based on gathering statistics, and consequently, adapt rather slowly to changes in conditions. To meet the strict latency requirements of streaming applications, we designed and implemented an advanced control algorithm that uses signal-strength (SNR) information to achieve fast responses. Since SNR readings are quite noisy we do not use that information to directly control the rate setting, but rather as a safeguard limiting the range of feasible settings to choose from. We report on real-time experiments involving two laptops equipped with IEEE 802.11a wireless interface cards. The results show that using SNR information greatly enhances responsiveness in comparison to statistics-based rate controllers.
An Atomic Receiver for AM and FM Radio Communication (2020)

Radio reception relies on antennas for the collection of electromagnetic fields carrying information, and receiver elements for demodulation and retrieval of the transmitted information. Here, we demonstrate an atom-based receiver for AM and FM microwave communication with a 3 dB bandwidth in the baseband of ~100 kHz that provides optical circuit-free field pickup, multiband carrier capability, and inherently high field sensitivity. The atom-based receiver exploits field-sensitive cesium Rydberg vapors in a centimeter-sized glass cell, and electromagnetically induced transparency, a quantum-optical effect, as a readout of baseband signals modulated onto carriers with frequencies ranging over four octaves, from C-band to Q-band. Receiver bandwidth, dynamic range and sideband suppression are characterized, and acquisition of audio waveforms of human vocals demonstrated. The atomic receiver is a valuable receiver technology because it does not require antenna structures and is resilient against electromagnetic interference, while affording multiband operation in a single compact receiving element.