gebhart/patrepeval huggingface dataset:
Long-Term Colonization Dynamics of Enterococcus faecalis in Implanted Devices in Research Macaques (2018)

<i>Enterococcus faecalis</i> is a common opportunistic pathogen that colonizes cephalic recording chambers (CRCs) of macaques used in cognitive neuroscience research. We previously characterized 15 <i>E. faecalis</i> strains isolated from macaques at the Massachusetts Institute of Technology (MIT) in 2011. The goal of this study was to examine how a 2014 protocol change prohibiting the use of antimicrobials within CRCs affected colonizing <i>E. faecalis</i> strains. We collected 20 <i>E. faecalis</i> isolates from 10 macaques between 2013 and 2017 for comparison to 4 isolates previously characterized in 2011 with respect to the sequence type (ST) distribution, antimicrobial resistance, biofilm formation, and changes in genes that might confer a survival advantage. ST4 and ST55 were predominant among the isolates characterized in 2011, whereas the less antimicrobial-resistant lineage ST48 emerged to dominance after 2013. Two macaques remained colonized by ST4 and ST55 strains for 5 and 4 years, respectively. While the antimicrobial resistance and virulence factors identified in these ST4 and ST55 strains remained relatively stable, we detected an increase in biofilm formation ability over time in both isolates. We also found that ST48 strains were typically robust biofilm formers, which could explain why this ST increased in prevalence. Finally, we identified mutations in the DNA mismatch repair genes <i>mutS</i> and <i>mutL</i> in separate ST55 and ST4 strains and confirmed that strains bearing these mutations displayed a hypermutator phenotype. The presence of a hypermutator phenotype may complicate future antimicrobial treatment for clinically relevant <i>E. faecalis</i> infections in macaques.<b>IMPORTANCE</b><i>Enterococcus faecalis</i> is a common cause of health care-associated infections in humans, largely due to its ability to persist in the hospital environment, colonize patients, acquire antimicrobial resistance, and form biofilms. Understanding how enterococci evolve in health care settings provides insight into factors affecting enterococcal survival and persistence. Macaques used in neuroscience research have long-term cranial implants that, despite best practices, often become colonized by <i>E. faecalis</i> This provides a unique opportunity to noninvasively examine the evolution of enterococci on a long-term indwelling device. We collected <i>E. faecalis</i> strains from cephalic implants over a 7-year period and characterized the sequence type, antimicrobial resistance, virulence factors, biofilm production, and hypermutator phenotypes. Improved antimicrobial stewardship allowed a less-antimicrobial-resistant <i>E. faecalis</i> strain to predominate at the implant interface, potentially improving antimicrobial treatment outcomes if future clinical infections occur. Biofilm formation appears to play an important role in the persistence of the <i>E. faecalis</i> strains associated with these implants.
Evidence for a neuroimmunomodulatory and a hematopoietic role of the Luschka's coccygeal body(3). (2000)

OBJECTIVES: In humans the glomus coccygeus was described in 1860 by Luschka. It is present at the coccyx tip and corresponds to a complex anastomosis between the median sacral artery and vein, and it is innervated by sympathetic fibers. In rats and mice it has been located in the tail ventral face. Its function is not known. According to our previous work, which demonstrated that hematopoiesis is under a noradrenergic control and based on the presence of epithelioid cells and sympathetic innervation, we assumed that the coccygeal gland might influence hematopoiesis via neuroendocrine or neural mechanisms. Therefore, the present study was undertaken to analyze the effect of glomus coccygeus on hematopoiesis. MATERIAL AND METHODS: Peripheral blood leukocyte and platelet concentrations as well as body temperature (BT) and body weight (BW), and norepinephrine (NE), adrenaline (A) and dopamine (DA) content in bone marrow of Luschkaectomized (LCGx), Sham LCGx operated (ShLCGx) and normal mice (Co) were investigated. RESULTS: We found that in LCGx vs. ShLCGx and Co, platelets and neutrophils increased while lymphocytes decreased. The effect of LCGx was significant from day 0 until day 65. Total leukocytes, monocytes, granulocytes, eosinophils and BT did not show any variation. Moreover, 22 days after the operation the amount of NE, A and DA seemed to be decreased in LCGx vs. ShLCGx while the difference was less evident between ShLCGx vs. Co. CONCLUSIONS: This study suggests for the first time a possible hematopoietic function and an immunomodulatory activity of the "Luschka's body" or Coccygeal body by a modulation of the sympathetic nervous system.
Distribution and Seasonal Occurrence of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) on the Island of Kauai in the Hawaiian Islands1 (1983)

Journal Article Distribution and Seasonal Occurrence of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) on the Island of Kauai in the Hawaiian Islands Get access Roger L. Vargas, Roger L. Vargas 2Tropical Fruit and Vegetable Research Laboratory. USDA-ARS. P.O. Box 2280 Honolulu. HI 96804 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ernest J. Harris, Ernest J. Harris 2Tropical Fruit and Vegetable Research Laboratory. USDA-ARS. P.O. Box 2280 Honolulu. HI 96804 Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshiyuki Nishida Toshiyuki Nishida 3Dept. of Entomology. University of Hawaii. 3050 Maile Way. Honolulu. HI 96822 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 12, Issue 2, 1 April 1983, Pages 303–310, https://doi.org/10.1093/ee/12.2.303 Published: 01 April 1983 Article history Received: 02 March 1982 Published: 01 April 1983
The Long Shadow of Temperament (2009)

Prologue 1. Overview 2. The Tapestries of Temperament 3. Biological Responses to Unfamiliarity 4. Behavioral and Biological Assessments 5. Integrating Behavior and Biology 6. Implications References Index
PIM Designated Router Load Balancing (2020)

On a multi-access network, one of the PIM-SM (PIM Sparse Mode) routers
is elected as a Designated Router. One of the responsibilities of the
Designated Router is to track local multicast listeners and forward
data to these listeners if the group is operating in PIM-SM. This
document specifies a modification to the PIM-SM protocol that allows
more than one of the PIM-SM routers to take on this responsibility so
that the forwarding load can be distributed among multiple routers.
SYNTHÈSE PROTÉIQUE IN VIVO DANS DIVERS TISSUS DU RAT EN CROISSANCE EN FONCTION DU RYTHME ALIMENTAIRE (1975)

Des rats croissance rapide (6, 7 g/j), clairs de 7 19 h et nourris, soit ad libitum, soit en 6 repas gaux distribus toutes les 4 heures partir de 10 h 30 , reoivent 10 yci de L-lysine-14 C par injection intrapritonale, soit 15 h soit 23 h. La synthse protique dans le foie, l'appareil digestif et diffrentes fractions protiques du muscle est estime par la mesure de la radioactivit incorpore dans les protines en tenant compte de la radioactivit du prcurseur. Le catabolisme protique dans le foie et le muscle est estim par la mesure de l'activit catheptasique (D) totale des tissus. Le catabolisme oxydatif de la lysine est dtermin par la mesure de l'volution de la RAS du l4 C0 2 aprs l'injection.
dc field effect on stability of piezoelectric PZN-0.06PT single crystals under compressive stress (2009)

A reversible elastic instability was observed in PZN-0.06PT high coupling single crystals when subjected to uniaxial compressions similar to those used in sound projectors. The strain magnitude at the onset of the instability supported a free energy prediction of a ferroelectric rhombohedral (FR)-ferroelectric orthorhombic (FO) phase transition. The thermal response of the normalized phase transition strain is in a good agreement with model calculation. A dc bias field drastically enhanced the crystal stability under compression. dc bias and compressive stress levels that are required for their stable operation in sound projectors have been deduced and will be presented.
Chloroplast Damage Induced by the Inhibition of Fatty Acid Synthesis Triggers Autophagy in Chlamydomonas (2018)

Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function. Here, we show that inhibition of fatty acid synthesis in the model alga <i>Chlamydomonas reinhardtii</i> activates autophagy, a highly conserved catabolic process by which cells degrade intracellular material under adverse conditions to maintain cell homeostasis. Treatment of <i>Chlamydomonas</i> cells with cerulenin, a specific fatty acid synthase inhibitor, stimulated lipidation of the autophagosome protein ATG8 and enhanced autophagic flux. We found that inhibition of fatty acid synthesis decreased monogalactosyldiacylglycerol abundance, increased lutein content, down-regulated photosynthesis, and increased the production of reactive oxygen species. Electron microscopy revealed a high degree of thylakoid membrane stacking in cerulenin-treated cells. Moreover, global transcriptomic analysis of these cells showed an up-regulation of genes encoding chloroplast proteins involved in protein folding and oxidative stress and the induction of major catabolic processes, including autophagy and proteasome pathways. Thus, our results uncovered a link between lipid metabolism, chloroplast integrity, and autophagy through a mechanism that involves the activation of a chloroplast quality control system.
Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. (2010)

Adoptive immunotherapy using gammadelta T-cells was shown here to be clinically beneficial and safe, and may become a therapeutic option for patients with advanced RCC.
The relationship between dental caries status and dental plaque urease activity (2007)

This study suggests that loss of alkali-generating potential of tooth biofilms via the urease pathway has a positive relationship to dental caries.
Functional Assessment of the Pharynx at Rest and during Swallowing in Partially Paralyzed Humans (1997)

Vecuronium-induced partial paralysis cause pharyngeal dysfunction and increased risk for aspiration at mechanical adductor pollicis TOF ratios < 0.90. Pharyngeal function is not normalized until an adductor pollicis TOF ratio of > 0.90 is reached. The upper esophageal sphincter muscle is more sensitive to vecuronium than is the pharyngeal constrictor muscle.
Actigraphy Validation with Insomnia (2006)

Actigraphy proved to be a satisfactory objective measure of sleep on 4 of 5 sleep parameters, but these results are specific to this particular instrument using this particular algorithm and should not be construed as a blanket endorsement of actigraphy for measuring insomnia.
ChemInform Abstract: Neutral Six‐Coordinate Phosphorus (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance of SOI devices transferred onto passivated HR SOI substrates using a layer transfer technique (2006)

High resistivity (HR) silicon wafers are promising candidates for RF applications due, mainly, to their low cost, CMOS compatibility and substantial substrate loss reduction (Eggert et al., 1997). However, oxidized HR silicon (such as HR SOI material) is known to suffer from parasitic surface conduction (PSC) below the oxide (Gamble et al., 1999) which can reduce the effective resistivity (rho <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> ) of the wafers by more than one order of magnitude (Lederer and Raskin, 2003). This issue can be overcome by introducing a trap-rich passivation layer between the oxide and the Si substrate, such as polysilicon (Gamble et al., 1999). In this paper we demonstrate for the first time that: (1) polySi substrate passivation can be efficiently realized on an industrial SOI technology using a post-process circuit transfer technique and that: (2) this technique preserves the performance of active devices
A network protocol for distributed orchestration using intent-based forwarding (2019)

Network management systems have undergone tremendous changes to adapt to the growing complexity and diversity of network deployments. A new trend of intent-based frameworks has emerged, where network administrators only input an abstract view of their desired network model instead of specifying the necessary steps to attain it. Intent-based networking holds the promise of autonomous, agile, and learning networks that configure themselves according to abstract policy without requiring human intervention.In this demonstration, we introduce a novel architecture for distributed intent-based network orchestration. For this purpose, we first extend the standard YANG to carry intent rather than configuration, adding missing features for in-network orchestration. Second, we use the model intents as network-native objects on which to perform routing and forwarding in-between orchestrators. Finally, we highlight the benefits of pushing intent in the network rather than fully processing it in a centralized orchestrator and illustrate potential improvements in term of scalability, programmability, and reliability.
Lightweight Exoskeletons with Controllable Actuators (2004)

A proposed class of lightweight exoskeletal electromechanical systems would include electrically controllable actuators that would generate torques and forces that, depending on specific applications, would resist and/or assist wearers movements. The proposed systems would be successors to relatively heavy, bulky, and less capable human-strength-amplifying exoskeletal electromechanical systems that have been subjects of research during the past four decades. The proposed systems could be useful in diverse applications in which there are needs for systems that could be donned or doffed easily, that would exert little effect when idle, and that could be activated on demand: examples of such applications include (1) providing controlled movement and/or resistance to movement for physical exercise and (2) augmenting wearers strengths in the performance of military, law-enforcement, and industrial tasks. An exoskeleton according to the proposal would include adjustable lightweight graphite/epoxy struts and would be attached to the wearer's body by belts made of hook-and-pile material. At selected rotary and linear joints, the exoskeleton would be fitted, variously, with lightweight, low-power-consumption rotary and linear brakes, clutches, and motors. The exoskeleton would also be equipped with electronic circuitry for monitoring, control, and possibly communication with external electronic circuits that would perform additional monitoring and control functions.
Is There Functional Collateral Flow During Vascular Occlusion in Angiographically Normal Coronary Arteries? (2003)

In humans with angiographically normal coronary arteries, there are functional collateral vessels to the extent that one fifth to one quarter of them do not show signs of myocardial ischemia during brief vascular occlusions.
Abstract 3129: A platform to assess multiple therapy options simultaneously in a patient's own tumor (2014)

Abstract Proper selection of anti-cancer agents at the earliest stage of patient treatment following diagnosis of disease relapse is expected to substantially impact clinical response to treatment. Currently, genomic approaches to personalized cancer treatments have been yielded mixed results, while empirical tests to assess tumor responsiveness have been limited to ex vivo systems that disrupt the native tumor microenvironment and show limited predictive value. To address the need for multiplexed in vivo chemosensitivity testing, we have developed a technology that allows simultaneous assessment of multiple cancer therapeutics directly in a patient's tumor. This technology could provide a valuable decision-making tool to prioritize effective treatments in the oncology clinic. Data herein highlight how this technology enables controlled and reliable microinjection of multiple drugs simultaneously in preclinical tumor models, canine lymphoma, and human lymphoma patients. Consistent with the controlled drug delivery of this system, spatially localized, readily detectable, and mechanism-specific cellular changes were observed around sites of microinjection in response to classic chemotherapy drugs (vincristine and doxorubicin) as well as to a small molecule inhibitor of TOR kinase. Importantly, localized response (or lack thereof) to individual components of CHOP combination therapy correlated with response to long-term systemic drug administration across multiple cell line and patient-derived xenograft models of lymphoma. Underscoring the importance of assessing drug efficacy in the context of an intact in vivo system, tumor responses to vincristine were impacted by the local tumor microenvironment. Our results also emphasize the importance of selecting effective therapies early in the course of treatment, as drug resistance mechanisms induced cross-resistance to otherwise efficacious drugs. These studies set the stage for use of this platform in oncology drug development, where the ability to more rapidly assess drug efficacy using clinically relevant in vivo tumors may decrease the current reliance on in vitro cell-based models of cancer and possibly increase the likelihood of clinical success. This platform may thus be useful a clinical decision-making tool for selection of patient-specific anti-cancer therapies. Citation Format: Richard Klinghoffer, Alicia Moreno-Gonzalez, Michael Carleton, Jason Frazier, Marc Grenley, Ilona Tretyak, Nathan Hedin, Joyoti Dey, Joseph Casalini, Beryl Hatton, Sally Ditzler, James Olson, Daniel Pierce, Ellen Filvaroff, Nathan Caffo. A platform to assess multiple therapy options simultaneously in a patient's own tumor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3129. doi:10.1158/1538-7445.AM2014-3129
Evaluation of carotid artery atherosclerotic plaque distribution by using long-axis high-resolution black-blood magnetic resonance imaging (2008)

Long-axis BB-MR imaging can provide a noninvasive and accurate way to show CA plaque distribution; it is of great use not only for stroke risk assessment in patients with CA atherosclerosis but also for preoperative evaluation in patients requiring CA endarterectomy or CA stent placement.
Depression Following Myocardial Infarction (1993)

Major depression in patients hospitalized following an MI is an independent risk factor for mortality at 6 months. Its impact is at least equivalent to that of left ventricular dysfunction (Killip class) and history of previous MI. Additional study is needed to determine whether treatment of depression can influence post-MI survival and to assess possible underlying mechanisms.
Novobiocin-dependent topA deletion mutants of Escherichia coli (1991)

Previous reports of the transduction of topA deletions in Escherichia coli suggested that delta top A transductants grow normally only if they acquire spontaneous mutations that compensate for the topoisomerase I defect. We show that P1-mediated transduction of delta topA in the presence of sublethal concentrations of novobiocin, an inhibitor of the DNA gyrase B subunit, yields uncompensated Top- isolates which are dependent on novobiocin for optimum growth. In the absence of novobiocin these delta topA strains grow slowly, indicating that topA deletions are deleterious but not lethal to the cell. We propose that inhibitors of DNA gyrase B, presumably by lowering intracellular levels of DNA supercoiling, can phenotypically suppress a topoisomerase I defect in E. coli.
A Thin Silicon Solar Cell on Glass: Cell Design and Process Physics (1999)

We describe a new design for a low-cost thin-film solar cell on a glass substrate. The structure of the cell is discussed in detail. Several verified steps in the fabrication of this cell are also presented.
Concatenation of space-time block codes and "turbo"-TCM (2003)

For high data rate transmission over wireless fading channels space-time block codes provide the maximal possible diversity advantage for multiple transmit antenna systems with a very simple decoding algorithm. To achieve also a significant coding gain space-time block codes have to be concatenated with an outer code. We derive a symbol by symbol MAP decoding rule for space-time block codes. We describe two schemes for "turbo"-TCM which have been shown to achieve decoding results close to the Shannon limit in AWGN channels. These turbo-TCM schemes are concatenated to space-time block codes. The MAP decoding algorithm is described. We also discuss a feedback to the space-time block decoder. Significant coding gain in addition to the diversity advantage is shown to be achieved while the decoding complexity is mainly determined by the trellis complexity of the outer code.
122 Preoperative imaging assessment of Peritoneal Cancer Index (PCI): concordance with surgical findings in advanced ovarian cancer. A prospective study (2021)

<h3>Introduction/Background*</h3> The extent of peritoneal spread in advanced ovarian cancer (AOC) heavily impacts on the chance of a complete surgical cytoreduction. The decision-making process on the feasibility of cytoreductive surgery should include a dedicated imaging evaluation. The aim of this study was to prospectively compare a radiologic Peritoneal Cancer Index (rPCI) with the surgical PCI (sPCI). <h3>Methodology</h3> 128 consecutive AOC patients planned for cytoreductive surgery underwent preoperative contrast-enhanced Computed Tomography (CT) scan to calculate the rPCI, then the sPCI was determined intraoperatively. CT scans were performed by two dedicated radiologists, and re-evaluated by a third. The rPCI correlation with sPCI was calculated by Lin’s Concordance Correlation Coefficient (CCC), and represented by Bland-Altman agreement plot and Passing-Bablok regression line. <h3>Result(s)*</h3> Primary debulking surgery (PDS), and interval debulking surgery (IDS) were performed in 88 and 40 patients, respectively (complete cytoreduction in 56.8% PDS and 67.5% IDS). Overall, mean±SD rPCI was 16.2±6.4 (95%CI:15.1-17.3) and sPCI 14.7±6.9 (95%CI:13.5-15.9), showing a moderate correlation between preoperative CT scan and surgical findings (figures 1-2, CCC=0.64). The best concordance was reported for PDS vs. IDS (CCC=0.64 vs. 0.60) and in middle-high abdominal vs. low quadrants (CCC=0.57 vs. 0.40), while rPCI overestimated ileo-jejunal spread (CCC=0.21). <h3>Conclusion*</h3> CT is moderately accurate in predicting the sPCI in AOC patients. The rPCI scoring seems to be helpful and should be part of the decision-making process on surgical cytoreduction.