gebhart/patrepeval huggingface dataset:
Purification of soluble murine transplantation antigens by isoelectric focusing (1970)

Hydrosoluble transplantation antigens were prepared from membranes and microsomes of C(3)H mice (BP8 tumoral cells) and purified by isoelectric focusing. A biologically active fraction which seems homogenous by acrylamide gel electrophoresis was characterized: it specifically inhibits anti C(3)H hemagglutinin antibodies and provokes a highly significant prolongation of skin graft.
Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926 (2016)

The formation of the d-homocyclopamine ring system in IPI-926 is the key step in its semisynthesis and proceeds via a chemoselective cyclopropanation followed by a stereoselective acid-catalyzed carbocation rearrangement. In order to perform large-scale cyclopropanation reactions, we developed new iodomethylzinc bis(aryl)phosphate reagents that were found to be both effective and safe. These soluble reagents can be prepared under mild conditions and are stable during the course of the reaction. Importantly, they have favorable energetics relative to other cyclopropanating agents such as EtZnCH2I. Herein, we describe the process optimization studies that led to successful large-scale production of the d-homocyclopamine core necessary for IPI-926.
Motion Strategies for Surveillance (2008)

We address the problem of surveillance in an environment with obstacles.We show that the problem of tracking an evader with one pursuer around one corner is completely decidable.The pursuer and the evader have complete information about each other's instantaneous position.The pursuer has complete information about the instantaneous velocity of the evader.We present a partition of the visibility region of the pursuer where based on the region in which the evader lies, we provide strategies for the evader to escape the visibility region of the pursuer or for the pursuer to track the target for all future time.We also present the solution to the inverse problem: given the position of the evader, the positions of the pursuer for which the evader can escape the visibility region of the target.These results have been provided for varying speeds of the pursuer and the evader.Based on the results of the inverse problem we provide an O(n 3 log n) algorithm that can decide if the evader can escape from the visibility region of a pursuer for some initial pursuer and evader positions.Finally, we extend the result of the target tracking problem around a corner in two dimensions to an edge in three dimensions.
From Epiraikovenal, an Instrumental Niche‐Exploitation Sesquiterpenoid of Some Strains of the Marine Ciliated Protist euplotes raikovi, to an unusual intramolecular tele‐dienone‐olefin [2+2] photocycloaddition (1995)

Abstract It is shown that strains of the marine ciliate Euplotes raikovi are subtly variable in their production of secondary metabolites. Strains GA8 and 39W from Mediterranean and SB8 from Californian coasts produce the sesquiterpenoid epiraikovenal ( 3 ), while strains GA8 and SB8 also produce secoepiraikovenal ( 4 ), which play an instrumental niche‐exploitation role and have also taxonomic significance. Comparison of 3 and 4 with raikovenal ( 2 ) and its putative biogenetic precursor 1 , which have similar roles in the conspecific strain Morl from Casablanca coast in the Atlantic Ocean, inspired us the first case of intramolecular tele ‐dienone‐olefin [2+2] photocycloaddition, exemplified here by the transformation of 1 into ent ‐ 3 . This served also to unequivocally clarify the stereochemical relationship between 3 and 2 .
Intracranial chemical-shift artifacts on MR images of the brain : observations and relation to sampling bandwidth (1990)

The purpose of this study was to evaluate the presence of chemical-shift artifacts on cranial MR and to illustrate the interrelationship among chemical-shift artifacts, variable acquisition parameters, and field strength. Measurements of chemical-shift artifacts were performed on scans obtained from a volunteer imaged in a 1.5-T General Electric system at bandwidths of 8, 16, and 32 kHz, using a 24-cm field of view and an 8-kHz bandwidth with a 48-cm field of view. Chemical-shift displacements at 8 kHz were 6.6 and 14.2 mm at the respective fields of view. Retrospective review was also performed in 77 cases of cranial MR performed on a 1.4-T Technicare unit for the presence and source of chemical-shift artifact on spin-density and T2-weighted images. Most data reviewed showed no significant interference of chemical-shift artifacts on cranial images. An artifactual subdural fluid collection was a common artifact (n = 30/77). When present, this was due to shift of fat signal from subcutaneous tissues onto the brain in patients younger than 10 years old (n = 4/10) and correlated with the distance between brain and subcutaneous fat of less than the linear value of the chemical shift. When this artifact was present in adults (n = 25/67), it was due to shift of the medullary fat signal across the inner table of the skull. The latter also occurred in one child under 10. Apparent location shifts, consistent with the displacement expected from the chemical-shift artifact, were noted in five of five cases of intracranial lipoma. In one of these, the chemical-shift artifact disguised the presence of a large associated vessel. The method of calculating the linear displacement of chemical-shift artifact is reviewed, and the interrelationship of machine parameters and chemical-shift artifact is illustrated. Chemical-shift artifact increases proportionally with field strength and field of view. Increasing the bandwidth to decrease chemical-shift artifact has a resultant penalty in signal to noise but allows a lower time to echo. A lower time to echo can also be accomplished without increasing the bandwidth if asymmetric sampling is used. Awareness of the relationships among chemical-shift artifacts, acquisition parameters, and field strengths can result in a more tailored examination when the chemical-shift artifact is going to be a significant factor. In addition, interpreter error can be avoided by awareness of these relationships when reviewing images from outside institutions.
Supercontinuum generation in microstructured ZBLAN fibre with six nanobore cores (2016)

We report fabrication of a microstructured ZBLAN fibre with six cores each containing a nanobore of diameter ~330 nm. Spectral broadening is observed when pumped by 1042 nm pulses in both fundamental and higher order modes.
Relationship between compliance by adolescent orthodontic patients and performance on psychological tests. (1990)

Two hundred and fifty-two adolescent orthodontic patients were categorized according to their general level of compliance during orthodontic treatment. Each patient completed three standardized psychological tests, (1) The Comprehensive Personal Assessment System: Self-Report Inventory, by Oliver H. Bown, (2) The Adolescent Alienation Index, by F. K. Heussenstamm, and (3) The Home Index, by Harrison Gough. The most important variable in predicting compliance was the sex of the patient. Females were more compliant than males. The psychological tests indicated that more compliant patients scored higher on self-esteem, derived self-satisfaction from personal achievement, were optimistic regarding the future, had higher socioeconomic status and had a low degree of general alienation from society. These easy-to-administer, brief psychological inventories could be helpful to clinicians in anticipating compliance problems during orthodontic treatment.
RF bridges to the network [RF IC design] (2001)

Chips that dwell at the boundary between the electronics and the transmission medium and run at network speeds are growing in importance, and so are the tools that design them. In this paper, RF IC design tools and their developers are examined by the author.
Evaluation of first generation CASA radar waveforms in the IP1 testbed (2007)

The Center for Collaborative Adaptive Sensing of the Atmosphere (CASA), an engineering research center (ERC) established by the National Science Foundation (NSF) deployed its first generation network of four low-power, short-range, X- band, dual-polarized Doppler weather radars known as NE- TRAD. The short range CASA radars will have range overlay and velocity folding problems with conventional pulse-pair processing. The first testbed of X-band radar systems (developed within the ERC) in central Oklahoma called IP-1 (Integrated Project 1) have a low unambiguous velocity due to their short wavelength, and increasing the PRF will result in multiple trip overlays since storms can extend over a large distance. In addition the radar observations at short ranges are contaminated by ground clutter. This paper describes the waveforms for the individual radar nodes based on NETRAD operational requirements such as scan speeds, volume coverage pattern and system/hardware limitations to resolve range and velocity ambiguities. A dual PRF waveform has been suggested for operational use based on a simulation study. This paper presents an evaluation of the waveform from data collected by the first generation CASA radars.
MEDIUM TERM FOLLOW UP OF PATIENTS WITH PERCUTANEOUS OR OPEN LUMBAR DISCECTOMY – CAN MRI ACCURATELY DIAGNOSE THE EXTRUDED DISC PROLAPSE? (2006)

Study design: A prospective comparison of MRI findings with surgical findings in patients presenting to our spinal triage service with a prospective diagnosis of a lumbar disc herniation. Objective: To investigate consistency between radiologists interpretation of MRI scans, and comparison between MRI and surgical findings, in an attempt to identify those patients suitable for percutaneous treatment. Background: MRI has assumed a preeminent position in the diagnosis of lumbar disc prolapse. Methods: 87 consecutive patients presenting with signs and symptoms suggestive of a lumbar disc prolapse that underwent an MRI and based on that a discectomy. Results: Reliability tests show only fair agreement (k=0.36) between the radiologists and at best only moderate agreement (k=0.41) between the radiologists and surgical findings. Conclusions: MRI is an excellent tool for diagnosis of a disc prolapse but does not appear to help in classifying discs suitable for percutaneous treatment.
Novel Open-Framework Material:  Cerium Oxyfluoride with CeO6F2 Dodecahedron (2000)

A novel open-framework cerium oxyfluoride, YU-1, has been hydrothermally synthesized. Its structure contains CeO6F2 dodecahedra as a new type of basic building unit. The octahedral Ce6O24F12 cage formed by CeO6F2 dodecahedra connect to one another via bridging oxygen atoms to give rise to a 3-D channel system with an eight-ring pore opening. At the intersections of the channels, there are large supercages with the longest body diagonal of ∼17 Å.
Response speed of SnO2-based H2S gas sensors with CuO nanoparticles (2004)

CuO nanoparticles on sputtered SnO2 thin-film surface exhibit a fast response speed (14 s) and recovery time (61 s) for trace level (20 ppm) H2S gas detection. The sensitivity of the sensor (S∼2.06×103) is noted to be high at a low operating temperature of 130 °C. CuO nanoparticles on SnO2 allow effective removal of excess adsorbed oxygen from the uncovered SnO2 surface due to spillover of hydrogen dissociated from the H2S–CuO interaction.
Hyaluronic acid therapy. (2000)

A significant amount of evidence exists suggesting beneficial effects of intra-articular hyaluronate preparations in treating the symptoms of OA. The beneficial effects of these compounds tend to persist for several months after cessation of therapy, unlike anti-inflammatory drug effects. In addition, several clinical trials comparing these agents to anti-inflammatory medications indicate efficacy of symptom improvement equivalent to that of the anti-inflammatories. A few clinical studies have failed to demonstrate an effect, and clearly much work remains to be done in this area to fully determine rational treatment strategies with these agents. The symptom improvement is generally moderate, and additive effects of these agents with anti-inflammatories have not been demonstrated. Adverse local reactions have been reported in some clinical series of hyaluronate injections. Although the invasive nature of the procedure is a drawback, overall it appears to be well tolerated and is probably not harmful to articular cartilage, a major advantage over the widely practiced introduction of intra-articular steroids. Documentation of true chondroprotective effects or alteration of the natural history of cartilage degeneration by these agents is lacking in the clinical literature and awaits further study. Cost effectiveness of this therapy versus other treatments, including the costs of treatment of side effects, also requires further rigorous evaluation, and may influence acceptability of this form of treatment to various health care providers and organizations.
A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection (2011)

A genetic absence of the common IFN-α/β signaling receptor (IFNAR) in mice is associated with enhanced viral replication and altered adaptive immune responses. However, analysis of IFNAR(-/-) mice is limited for studying the functions of type I IFN at discrete stages of viral infection. To define the temporal functions of type I IFN signaling in the context of infection by West Nile virus (WNV), we treated mice with MAR1-5A3, a neutralizing, non cell-depleting anti-IFNAR antibody. Inhibition of type I IFN signaling at or before day 2 after infection was associated with markedly enhanced viral burden, whereas treatment at day 4 had substantially less effect on WNV dissemination. While antibody treatment prior to infection resulted in massive expansion of virus-specific CD8(+) T cells, blockade of type I IFN signaling starting at day 4 induced dysfunctional CD8(+) T cells with depressed cytokine responses and expression of phenotypic markers suggesting exhaustion. Thus, only the later maturation phase of anti-WNV CD8(+) T cell development requires type I IFN signaling. WNV infection experiments in BATF3(-/-) mice, which lack CD8-α dendritic cells and have impaired priming due to inefficient antigen cross-presentation, revealed a similar effect of blocking IFN signaling on CD8(+) T cell maturation. Collectively, our results suggest that cell non-autonomous type I IFN signaling shapes maturation of antiviral CD8(+) T cell response at a stage distinct from the initial priming event.
Nonmetallic Dielectric Resonator Antenna Using Carbon Nanotube Composite Materials (2012)

In this letter, we present a nonmetallic antenna for wireless applications comprising a circular disk dielectric resonator (DR) on a duroid substrate, with carbon nanotube (CNT) composite material. The radiation characteristics of the proposed DR-CNT antenna such as impedance bandwidth and peak gain are studied both numerically and experimentally. The effect of the ohmic losses in the CNT composite on the antenna efficiency is investigated. The DR-CNT antenna has useful gain and radiation characteristics over the operating frequency band near the resonance of DR, and therefore the proposed antenna is a good candidate for wireless applications requiring a nonmetallic antenna.
Paradoxical Embolism (1930)

Journal Article Paradoxical Embolism Get access Theodore Thompson, Theodore Thompson London Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar William Evans William Evans London Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume os-23, Issue 90, January 1930, Pages 135–150, https://doi.org/10.1093/qjmed/os-23.90.135 Published: 01 January 1930 Article history Received: 08 July 1929 Published: 01 January 1930
Schistosomiasis of spinal cord and skin. (1975)

We record the simultaneous occurrence of cutaneous and spinal cord lesions of schistosomiasis and speculate upon the mode of this distant spread.
The Simple and Protected Generic Security Service Application Program Interface (GSS-API) Negotiation Mechanism (2005)

This document specifies a negotiation mechanism for the Generic Security Service Application Program Interface (GSS-API), which is described in RFC 2743. GSS-API peers can use this negotiation mechanism to choose from a common set of security mechanisms. If per-message integrity services are available on the established mechanism context, then the negotiation is protected against an attacker that forces the selection of a mechanism not desired by the peers.
Direct synthesis of novel quinoxaline derivatives via palladium-catalyzed reductive annulation of catechols and nitroarylamines (2020)

Here, a palladium-catalyzed new hydrogenative annulation reaction of catechols and nitroarylamines, allowing straightforward access to two classes of novel quinoxaline derivatives, is reported. The reaction proceeds with operational simplicity, an easily available catalyst system, and a broad substrate scope, and without the need for pre-functionalization, which offers the potential for further design of new reductive transformations of renewable resources into value-added products.
Enabling Synchronous Joint Action in Human-Robot Teams (2015)

Joint action is an increasing area of interest for HRI researchers. To be effective team members, robots need to be able to understand, anticipate, and react appropriately to high-level human social behavior. We have designed a new approach to enable an autonomous robot to act fluently within a synchronous human-robot team. We present an initial description and validation study of this approach. Using a synchronous dance scenario as an experimental testbed, we found that our robot was able to execute appropriate actions using our method. Moving forward, we aim to extend this method by developing predictions for the robot's actions using an understanding of the group's dynamics. Our method will be helpful to other researchers working to achieve fluency of action within human-robot groups.
A 2/3-in. 9.5-Mpixel CMOS Imager With High Frame Rate and HDR Capabilities (2021)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">This study explains the architecture and readout schemes used to achieve a 2/3-in. 9.5-Mpixel complementary metal oxide semiconductor (CMOS) imager, with 3.6 Gpixels/s enabling high frame-rate operation in native UHD-1/4K ultrahigh-definition (UHD) resolution and full high-dynamic range (HDR) support. The presented imager demonstrates an architecture that supports high spatial and temporal resolutions and a high output data rate. To fulfill the transfer time requirements, an innovative row addressing scheme has been developed to toggle between the different rows</i> .
Advanced Cascade Multilevel Converter with Reduction in Number of Components (2014)

In this paper a novel converter structure based on cascade converter family is presented. The suggested multilevel advanced cascade converter has benefits such as reduction in number of switches and power losses. Comparison depict that proposed topology has the least number of IGBTs among all multilevel cascade type converters which have been introduced recently. This characteristic causes low cost and small installation area for suggested converter. The number of on state switches in current path is less than conventional topologies and so the output voltage drop and power losses are decreased. Symmetric and asymmetric modes are analyzed and compared with conventional multilevel cascade converter. Simulation and experimental results are presented to illustrate validity, good performance and effectiveness of the proposed configuration. The suggested converter can be applied in medium/high voltage and PV applications.
The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets. (1988)

Recombinant-derived human Factor VIII was labeled intrinsically with [35S]methionine, and its binding to washed human platelets was studied. Binding measurements were performed by incubating Factor VIII and platelets for 15 min at room temperature in Tyrode's solution supplemented with Ca2+ (5.0 mM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (5.0 mM), 0.50% bovine serum albumin, and the Factor Xa and thrombin inhibitors 5-dimethylaminonaphthalene-1-sulfonylglutamylglycinylarginyl chloromethyl ketone and 5-dimethylaminonaphthalene-1-sulfonyl-arginine-N-(3-ethyl-1, 5-pentanediyl)amide. Separation of free from bound Factor VIII was accomplished by centrifugation through oil, and nonspecific binding was determined with excess unlabeled Factor VIII. Binding was saturable, reversible, and stimulated 20-fold after platelet activation with thrombin. Furthermore, binding was specific in that bound labeled Factor VIII could be displaced by excess unlabeled Factor VIII, but not by Factor V. Scatchard analysis indicated a single class of binding sites with Kd = 2.9 nM and 450 sites/activated platelet. The time course of displacement indicated a t1/2 of bound Factor VIII of approximately 5 min. When platelets were incubated in Ca2+, both the heavy and light chains of Factor VIII were bound, whereas exposure to EDTA resulted in the binding of the light chain only. These results demonstrate the specific reversible binding of Factor VIII to human platelets, likely mediated through the light chain.
Changes in the plasma free amino acid profile of the Norway lobster Nephrops norvegicus at different stages of infection by a parasitic dinoflagellate (genus Hematodinium) (1999)

DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials DAO 38:151-157 (1999) - doi:10.3354/dao038151 Changes in the plasma free amino acid profile of the Norway lobster Nephrops norvegicus at different stages of infection by a parasitic dinoflagellate (genus Hematodinium) G. D. Stentiford1,*, D. M. Neil1, G. H. Coombs2 1Division of Environmental & Evolutionary Biology, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK 2Laboratory for Biochemical Parasitology, Division of Infection & Immunity, University of Glasgow, Glasgow G12 8QQ, Scotland, UK *E-mail: g.stentiford@udcf.gla.ac.uk ABSTRACT: The haemolymph free amino acid (FAA) composition of Norway lobsters Nephrops norvegicus from the Clyde estuary, Scotland, UK, at different stages of infection by the parasitic dinoflagellate Hematodinium sp. was determined by reverse phase high performance liquid chromatography (HPLC). In uninfected lobsters the total detected haemolymph FAA concentration was 3.79 µmol ml-1. Collectively, glycine, histidine/glutamine, alanine, serine, taurine and asparagine constituted 80% of the total. The concentrations of several FAAs, notably serine, were reduced in early infections (Stage 1), while at later stages (2-4) several FAAs were increased in concentration. The most significant change was in taurine, which had increased 13-fold (from 0.22 to 2.56 µmol ml-1) in the final infection stage, when its relative contribution to the total FAA was 41.6%. Possible causes of these changes in the lobster haemolymph FAAs are the breakdown of host tissues including the hepatopancreas and muscle, haemocyte lysis, a host stress response and release of FAAs from the parasite cells. Results indicate that the taurine:serine ratio in the haemolymph provides a sensitive diagnostic measure of patent Hematodinium infections. Implications of these FAA alterations for Hematodinium-infected N. norvegicus are discussed. KEY WORDS: Nephrops norvegicus · Haemolymph · Free amino acids · Taurine · Hematodinium Full text in pdf format PreviousNextExport citation RSS - Facebook - Tweet - linkedIn Cited by Published in DAO Vol. 38, No. 2. Publication date: November 08, 1999 Print ISSN:0177-5103; Online ISSN:1616-1580 Copyright © 1999 Inter-Research.