gebhart/patrepeval huggingface dataset:
Computerized Psychological Test System for Art Therapy (2010)

In this paper, we propose a computerized psychological test system for art therapy. The proposed system with the computerized devices can measure various information, such as colors, characters of lines, pen pressure, size of objects, position of objects, and so on, from the drawn pictures by the child. The measured information can be analyzed to extract more meaningful information about the child and to provide more effective remedial information for art therapy. Art therapy essentially has a potential drawback that the results of test can be influenced by therapist's subjectivity. The results can be different from the method of gathering information, the method of analysis, the interpretation of analyzed data, and even the therapist's academic backgrounds. Therefore, in this paper, we focus on what information needs to be measured and how to measure the data from drawn pictures and propose a computerized psychological test system for art therapy. The proposed system can measure and analyze various information from the drawn picture by the child. Since the proposed system can provide valuable psychological information of child in the form of quantitative data, it can be exploited as a new method for art therapy.
Supplementary Tables S1-S3 from Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor (2023)

&lt;p&gt;Supplementary Table S1. Background of Prostate Cancer Patients. Supplementary Table S2. List of the primers. Supplementary Table S3. 91 miRNAs upregulated in at least 1 of 3 cell lines.&lt;/p&gt;
<title>Role of RIE in microchip bond pad corrosion</title> (1996)

The discoloration of microchip bond pads due to the corrosive effects of the chemistries they are exposed to, poses a special problem for subsequent wire bonding operations. Such corrosion constitutes not only a cosmetic defect, but also interferes with the adhesion of the gold ball bonds to the bonding pads and compromises electrical connections to the device. These defects pose a serious reliability problem, and precautions must be taken in the manufacture of microelectronic devices to ensure that bond pad corrosion does not occur. This paper describes the phenomenon of bond pad staining/corrosion as well as the factors which influence its occurrence. A series of experiments were conducted to isolate and understand the corrosion mechanism, and the results of these experiments are presented. Finally, two different process modifications are presented which eliminate the occurrence of bond pad corrosion: a double sintering process, and the elimination of rf sputter etch prior to TiN ARC deposition on top layer metal.
Fabrication and Characterization of Cermet Supported Cell with SDC Electrolyte (2007)

Cermet supported cells with Sm0.2Ce0.8O1.9 (SDC) electrolyte have been developed and scaled up to 55mm x 55mm at NRC-IFCI. A solid oxide fuel cell with SDC electrolyte of 10µm in thickness and Ni-SDC anode of 15µm in thickness on a 0.8mm thick Ni-YSZ cermet substrate was fabricated by tape casting, screen printing, and co-firing. A composite cathode, 75 wt% Sm0.5Sr0.5CoO3 (SSCo) + 25 wt% SDC, approximately 50µm in thickness, was printed on the co-fired half-cell, and sintered at 1000{degree sign}C. The cell with effective cathode area of 16 cm2 showed a high electrochemical performance at 600{degree sign}C, and peak power density of 0.9W cm-2 was obtained with hydrogen fuel.
Interferon-Alpha Affects the Immune Response in Post-Transplant Lymphoproliferative Disorder (1996)

Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction. We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft. A reduction in immunosuppression and the addition of acyclovir did not result in improvement. Treatment with interferon-alpha (IFN-alpha), however, led to dramatic clinical, radiographic, and histologic improvement. Semiquantitative measurements of cytokine mRNA in his bronchoalveolar lavage cells prior to therapy with IFN-alpha revealed high levels of IL-4 and IL-10 mRNA, which decreased significantly with treatment. We speculate that the beneficial effect of IFN-alpha in the treatment of PTLD is directly related to the inhibition of type 2 helper (Th2-like) T-cells.
Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study (2023)

NCT02250729.
Multi‐scale compressional wave velocity structure of the San Gregorio Fault zone (2004)

Understanding fault architecture at multiple scales is crucial to delineate in situ fault zone physical properties and rupture dynamics through modeling and geophysical imaging/monitoring. An exposure of the active large‐offset, strike‐slip San Gregorio Fault at Moss Beach, CA provides a unique field site to relate the well‐mapped fault zone architecture with compressional wave velocity ( V p ) structure measured at centimeter to meter scales. Laboratory ultrasonic velocities of fault zone samples, adjusted for fluid‐related frequency and structural dispersion, indicate that (i) a seismic velocity reduction of ∼30% characterizes the central smectite‐rich clay gouge relative to the rocks 100 m away in the relatively undeformed host rocks, and (ii) the across‐fault velocity profile trends for the seismic to ultrasonic bandwidth correlate almost exactly to the previously mapped macroscale fault zone structure. These results highlight the value of conducting multiscaled investigations when measuring fault zone properties defined by physical elements at multiple scale lengths.
Heterologous biosynthesis of artemisinic acid in Saccharomyces cerevisiae (2016)

Artemisinic acid is a precursor of antimalarial compound artemisinin. The titre of biosynthesis of artemisinic acid using Saccharomyces cerevisiae platform has been achieved up to 25 g l(-1) ; however, the performance of platform cells is still industrial unsatisfied. Many strategies have been proposed to improve the titre of artemisinic acid. The traditional strategies mainly focused on partial target sites, simple up-regulation key genes or repression competing pathways in the total synthesis route. However, this may result in unbalance of carbon fluxes and dysfunction of metabolism. In this review, the recent advances on the promising methods in silico and in vivo for biosynthesis of artemisinic acid have been discussed. The bioinformatics and omics techniques have brought a great prospect for improving production of artemisinin and other pharmacal compounds in heterologous platform.
Structure and conformation of two coprogen-type siderophores. Neocoprogen I and neocoprogen II (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and conformation of two coprogen-type siderophores. Neocoprogen I and neocoprogen IIM. B. Hossain, M. A. F. Jalal, B. A. Benson, C. L. Barnes, and D. Van der HelmCite this: J. Am. Chem. Soc. 1987, 109, 16, 4948–4954Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ja00250a031https://doi.org/10.1021/ja00250a031research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Report of a double-blind crossover study of flurbiprofen and placebo in detrusor instability. (1983)

Thirty-seven elderly patients with idiopathic detrusor instability attending St. Pancras Hospital were entered into a double-blind crossover study of the prostaglandin synthetase inhibitor flurbiprofen (50 mg four times a day) and placebo, and twenty-seven patients completed the crossover. Flurbiprofen was significantly better than placebo in increasing the maximum contractile pressure. Flurbiprofen also significantly reduced the total number of voids and the number of urgent voids compared to baseline. Those patients whose volume to first contraction at baseline was less than 100 cm3 had further significant beneficial effects with flurbiprofen (increased volume at first sensation, volume at first contraction and total bladder capacity). Significant beneficial effects of placebo treatment (compared to baseline) were found for volume at first sensation and volume at first contraction, but only in those patients whose volume to first contraction at baseline was less than 50 cm3 and 100 cm3, respectively.
Orchestration of Reactions of Glycoluril Templates (1997)

Glycoluril 1 has been shown to act as a template, facilitating intramolecular Claisen-type condensations between bound acyl units. Repetitive acylations, condensations, and functional group manipulations allow the synthesis of complex structures from simple starting materials. Thus, the natural product tetradec-2-enoic acid-4,5-epoxide 2 was prepared by condensation on 1 of decanoic acid with two units of acetate. The 1-(3'-oxodecanoyl) glycoluril 3 was prepared from 1 via 4. Conversion to the dodecenoyl derivative 5 (2 steps), followed by a second cycle of acetylation, condensation, reduction and dehydration provided tetradeca-2,4-dienoyl glycoluril 6. Direct cleavage to the carboxylic acid, followed by epoxidation gave 2. Mono- (7) and di-thio (8) analogues of 1 are readily prepared using Lawesson's reagent; this novel application of Lawesson's reagent can be extend to N-acylglycolurils, leading to monacylmonothio derivatives (9) in which thionation occurs at the least hindered urea carbonyl. The thio analogues 7 and 8 are more readily acylated than 1; acylation of 7 occurs exclusively on the NH site adjacent to sulfur to give 10. All diacetylthioglycolurils underwent the Claisen-like condensation reaction to give acetoacetyl thioglycoluril derivatives; 11 undergoes selective deprotonation of the acetyl group adjacent to oxygen to give a mixture of 12 and 13 (2.2:1). Crossed-Claisen condensations of both isomers of acetyl-butanoyl monothioglycoluril (14, 15) afforded 3-ketohexanoyl and 2-ethyl-3-ketobutanoyl thioglycolurils (16 and 17, 18 and 19, respectively). Condensation of 14 led to a highly selective crossed-Claisen condensation (16:17 6:1); while condensation of 15 led to a reversal of regioselectivity (18:19 0.75:1). The x-ray crystallographic structures of key compounds in the glycoluril cycle were compared in order to improve understanding of geometrical factors involved in the condensation reaction. Additionally, several reactions in the cycle, including the first acylation, the condensation, the reduction, and the cleavage reactions were investigated to find conditions which lead to improved yields.
The histologic and functional characterization of enzymatically dispersed intestinal mast cells of nonhuman primates: effects of secretagogues and anti-allergic drugs on histamine secretion. (1985)

Despite the apparent involvement of gastrointestinal mast cells in hypersensitivity reactions in the mucosa, remarkably little information is available concerning the characteristics of these cells from man and higher animals. To study the characteristics of gastrointestinal mast cells from nonhuman primates, a previously described technique which uses a combination of mechanical and enzymatic methods to obtain mast cells from the tissues of rodents required modification to permit the successful dispersion of normal gastrointestinal tissues of higher animals. This modified procedure, as described in this report, appears to be relatively selective for mast cells located in the mucosal site, and typically yields ca 9 X 10(5) mast cells per gram of tissue. The mucosal mast cells obtained comprised ca 2% of the total nucleated cells, contained approximately 1 pg of histamine per cell, and stained metachromatically with toluidine blue only at low pH. The cells exhibited a dose-dependent release of histamine on challenge with goat anti-human IgE or the ionophores A23187 and Br-x537A but were refractory to the action of compound 48/80. IgE-mediated histamine release from monkey intestinal mast cells differed from that observed from rat intestinal mast cells in that release was inhibited not only by quercetin but also by theophylline. Disodium cromoglycate gave variable results. The data indicate that viable nonhuman primate mucosal mast cells can be obtained for study, and that these cells, although sharing some characteristics of mucosal mast cells from lower species, have distinct and unique properties. The availability of this nonhuman primate model for the study of mast cell function in higher animals should contribute to the understanding of mast cell-mediated diseases in man.
The Role of Tyk2 in Regulation of Breast Cancer Growth (2011)

The antigrowth and immunomodulatory actions of interferons (IFNs) have enabled these cytokines to be used therapeutically for the treatment of a variety of hematologic and solid malignancies. IFNs exert their effects by activation of the Jak/Stat signaling pathway. IFNγ stimulates the tyrosine kinases Jak1 and Jak2, resulting in activation of the Stat1 transcription factor, whereas type 1 IFNs (IFNα/β) activate Jak1 and Tyk2, which mediate their effects through Stat1 and Stat2. Disruption in the expression of IFNγ, IFNα receptors, or Stat1 inhibits antitumor responses and blunt cancer immunosurveillance in mice. Mutations in Jak2 or constitutive activation of Jak1 or Jak2 also promote the development of a variety of malignancies. Although there are data indicating that Tyk2 plays a role in the pathogenesis of lymphomas, the effects of Tyk2 expression on tumorigenesis are unknown. We report here that Tyk2(-/-) mice inoculated with 4T1 breast cancer cells show enhanced tumor growth and metastasis compared to Tyk2(+/+) animals. Accelerated growth of 4T1 cells in Tyk2(-/-) animals does not appear to be due to decreased function of CD4(+), CD8(+) T cells, or NK cells. Rather, the tumor suppresive effects of Tyk2 are mediated at least in part by myeloid-derived suppressor cells, which appear to be more effective in inhibiting T cell responses in Tyk2(-/-) mice. Our results provide the first evidence for a role of Tyk2 in suppressing the growth and metastasis of breast cancer.
Modification of the virtual-crystal approximation for ternary III-V compounds (1983)

We discuss a modification of the virtual-crystal approximation for alloys in the semiempirical tight-binding method of band-structure calculations, which explicitly includes the interactions between unlike second neighbors. The results are applied to the quaternary ${\mathrm{Ga}}_{y}{\mathrm{In}}_{1\ensuremath{-}y}{\mathrm{As}}_{x}{\mathrm{P}}_{1\ensuremath{-}x}$ and its constituent ternary compounds.
Uncertainty visualization in the VisIt visualization environment (2008)

Visualization and analysis of very large datasets remains a significant challenge to the visualization community. Scientists have tried various techniques to deal with large data. Multiresolution data models reduce the size of the data using techniques such as mesh decimation, wavelet transformation, or data compression. The low resolution representation raises issues concerning the authenticity of the data at its resolution level. We address this issue by presenting our extensions to the VisIt visualization environment that enable the scientist to visualize both multiresolution data and the uncertainty information associated with the lower resolution representations of the data.
A Modular Bioplatform Based on a Versatile Supramolecular Multienzyme Complex Directly Attached to Graphene (2016)

Developing generic strategies for building adaptable or multifunctional bioplatforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and because multifunctionality usually necessitates specific combinations of heterogeneous elements. Here, we introduce a generic, modular bioplatform construction strategy that uses cage-like supramolecular multienzyme complexes as highly adaptable building blocks immobilized directly and noncovalently on graphene. Thermoplasma acidophilum dihydrolipoyl acyltransferase (E2) supramolecular complexes organize as a monolayer or can be controllably transferred onto graphene, preserving their supramolecular form with specific molecular recognition capability and capacity for engineering multifunctionality. This E2-graphene platform can bind enzymes (here, E1, E2's physiological partner) without loss of enzyme function; in this test case, E1 catalytic activity was detected on E2-graphene over 6 orders of magnitude in substrate concentration. The E2-graphene platform can be multiplexed via patterned cotransfer of differently modified E2 complexes. As the E2 complexes are robust and highly customizable, E2-graphene is a platform onto which multiple functionalities can be built.
Transduction for Pheromones in the Main Olfactory Epithelium Is Mediated by the Ca2+-Activated Channel TRPM5 (2014)

Growing evidence suggests that the main olfactory epithelium contains a subset of olfactory sensory neurons (OSNs) responding to pheromones. One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential channel M5). Using GFP driven by the TRPM5 promoter in mice, we show that this subpopulation responds to putative pheromones, urine, and major histocompatibility complex peptides, but not to regular odors or a pheromone detected by other species. In addition, this subpopulation of TRPM5-GFP+ OSNs uses novel transduction. In regular OSNs, odorants elicit activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2+ gating of Cl- channels; in TRPM5-GFP+ OSNs, the Ca2+ -activated Cl- ANO2 (anoctamin 2) channel is not expressed, and pheromones elicit activation of the CNG channel leading to Ca2+ gating of TRPM5. In conclusion, we show that OSNs expressing TRPM5 respond to pheromones, but not to regular odors through the opening of CNG channels leading to Ca2+ gating of TRPM5.
OP09 Histological remission and mucosal healing in a randomised, placebo-controlled, Phase 2 study of etrasimod in patients with moderately to severely active ulcerative colitis (2019)

Etrasimod (APD334), an oral, selective sphingosine-1-phosphate receptor modulator, was evaluated in the randomised, double-blind, placebo-controlled, parallel-group, Phase 2 OASIS study (ClinicalTrials.gov identifier: NCT02447302) in patients with moderately to severely active ulcerative colitis (UC). Etrasimod demonstrated dose-dependent improvements in clinical response, clinical remission, and endoscopic appearance and decreased circulating lymphocytes. Here, we describe histological remission and mucosal healing results at Week 12. Patients were randomised to receive once-daily etrasimod 1 mg (n = 52) or 2 mg (n = 50), with no dose titration, or placebo (n = 54). At baseline and Week 12, endoscopic severity was assessed by sigmoidoscopy with central readings using the Mayo endoscopic subscore. Biopsies were taken, and histology results were scored by a blinded central pathologist using the Geboes index. Prespecified endpoint definitions were endoscopic improvement (Mayo endoscopic subscore of 0 or 1); histological improvement (Geboes score <3.1); and histological remission (Geboes score <2.0). Mucosal healing (a post hoc analysis) was defined as both endoscopic improvement and histological remission. Differences between groups were estimated using the Mantel–Haenszel analysis adjusted for current corticosteroid use at baseline and prior anti-tumour necrosis factor α use. Of 156 patients randomised, 90% completed the study. Etrasimod 2 mg, compared with placebo, resulted in significantly more patients who achieved endoscopic improvement (43.2% vs. 16.3%, respectively; p = 0.003), histological improvement (31.7% vs. 10.2%; p = 0.006), and histological remission (19.5% vs. 6.1%; p = 0.027) at Week 12 (Table). Mucosal healing was seen in 19.5% and 4.1% of patients treated with etrasimod 2 mg and placebo, respectively (p = 0.010). More patients receiving etrasimod 1 mg also achieved each endpoint compared with placebo; however, results did not reach statistical significance. Etrasimod 2 mg induced significantly higher rates of endoscopic improvement, histological improvement and remission, and mucosal healing in patients with moderately to severely active UC when compared with placebo. Mucosal healing may prove to be an achievable and objective measure of drug efficacy in UC induction studies. Abstract OP09 – Table. Endoscopic, histological, mucosal measures at Week 12.
Highly flexible connection unit for electrical machines with concentrated windings (2015)

This paper discusses a highly flexible connection unit for electrical machines with concentrated windings. First, some general restrictions and requirements on connection units are identified. Then a suitable joining technology for the connection unit is investigated. Afterwards, the design of the highly flexible connection unit is introduced and applied to a sample machine.
Research on Carbon Peak Prediction in Electric Power Industry Based on DeBruyn and System Dynamics Model (2023)

As a critical field of carbon emission, the clean and low-carbon transformation of power industry is extremely critical to the smooth realization of country’s "dual carbon" goal. From the perspective of the whole power industry chain, the DeBruyn decomposition method was firstly used to determine critical influence factors of carbon emission in the power industry. Next, the response relationship between the influence factors and carbon emission was established. Finally, the peak value and its occurrence time under various scenarios were identified through designing four typical scenarios. The obtained results demonstrated that, under the context of interactive influence among positive driving factors (population size, thermal power generation, industrial structure, GDP), negative driving factors (forest area, energy structure, science and technology investment) and other factors, the carbon-emission amounts of the power industry under baseline scenario were increased continuously; conversely, the peak value of carbon emission under two single carbon reduction policy scenarios (i.e. carbon trading policy and renewable energy quota policy) and their composition scenario would become decrease, being 5.46×109 tons, 5.61×109 tons and 5.16×109 tons, respectively. Correspondingly, the occurrence time of peak value under three scenarios was in 2029, 2029 and 2028, respectively.