gebhart/patrepeval huggingface dataset:
Reduction of electronic noise in inductively coupled plasma atomic emission and fluorescence spectrometric measurements (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of electronic noise in inductively coupled plasma atomic emission and fluorescence spectrometric measurementsG. L. Long, E. G. Voigtman, M. A. Kosinski, and J. D. WinefordnerCite this: Anal. Chem. 1983, 55, 8, 1432–1434Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ac00259a060https://doi.org/10.1021/ac00259a060research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations999LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DROPLET STREAM DYNAMICS AT HIGH AMBIENT PRESSURE (1996)

The wake of a leading droplet can influence a trailing droplet's behavior by altering the environment through which the trailing droplet travels. A high-ambient-pressure environment not only changes the result of any collisions by adding a strong shearing element, but the increase in aerodynamic forces also alters the droplet wake. Despite these effects, this work shows experimentally that classical small-perturbation theory for a cylindrical jet breakup into droplets holds over the range of ambient pressure from 1 to 70 atm. Further, the length of the stable droplet stream is controlled by droplet wake interactions and a droplet's ability to resist the inertial and shearing influences of the ambient gas. Secondary breakup transitions at high ambient pressures do not match those observed in isolated-droplet experiments. Collisions with satellite droplets at elevated pressures enhances deformation breakup significantly. Interestingly, shear stripping in a stream of droplets occurs in the Reynolds and Weber number regime associated with droplet deformation breakup in the isolated-droplet case. This rapid stripping phenomena may also be a result of wake interactions.
A reduced complexity cross between BALB/c substrains identifies Zhx2 as a candidate gene underlying oxycodone metabolite brain concentration and state‐dependent learning of opioid reward (2022)

Understanding the pharmacokinetic profile of an opioid drug is vital to therapeutic success, and mutations in human PK genes can drastically alter therapeutic efficacy of opioids. We observed that at 30 min post‐oxycodone administration (1.25 mg/kg, i.p.) BALB/cJ mice showed a higher whole brain concentration of oxycodone, and female specific increase in noroxycodone, and oxymorphone compared to BALB/cByJ. This observation could explain the sex‐specific increase in oxycodone state‐dependent conditioned place preference in BALB/cJ female mice. To potentially link behavioral differences with PK differences, we conducted quantitative trait locus ( QTL ) mapping of whole brain oxycodone and metabolite concentrations in a reduced complexity cross ( RCC ). Because BALB/cJ and BALB/cByJ substrains differ by ~8,500 SNPs/indels, large genetic loci identified in an F2 cross are offset by a dramatic reduction in potentially causal variants. QTL mapping in 133 BALB/cJ x BALB/cByJ F2 mice (68F, 65M) revealed a single QTL on chromosome 15 associated with brain oxymorphone concentration that explained 29% of the phenotypic variance in females. Oxymorphone is a full agonist at the mu opioid receptor, with 8x the potency of oxycodone, and likely contributes to oxycodone addictive properties. Hippocampal and striatal cis‐eQTL analysis revealed genetically regulated expression of Zhx2, a transcriptional inhibitor known to harbor a private BALB/cJ retroviral insertion that dramatically reduces protein expression and leads to sex specific dysregulation of CYP450 genes within the liver. Whole brain mass spectroscopy proteomics in the parental strains corroborated these eQTL findings. We hypothesize that decreased Zhx2 expression leads to increased CYP450 expression, increased brain oxymorphone, and increased oxycodone‐induced behaviors. Interestingly, human GWAS of nicotine consumption identified a nominal association (10^‐7) with ZHX2, indicating that this transcriptional repressor could influence metabolism of multiple drugs of abuse.
A new bias scheme for a low power consumption ReRAM crossbar array (2016)

This paper proposes a new bias scheme for a crossbar array that can improve the power consumption and read margin. The concept of the newly proposed 5/12 bias scheme is to reduce the bias of the unselected cells for power consumption and the bias of half-selected cells for a reduced line voltage drop of the selected cell. In the 5/12 bias scheme, the unselected word line and bit line are biased to 5 × Vapp/12 and 7 × Vapp/12, respectively. The electrical characteristics of the 5/12 bias scheme are evaluated by HSPICE simulations and it is found that appropriate nonlinearity of selector can simultaneously achieve low power consumption and high read margin for 5/12 bias scheme.
Direct detection of illicit drugs from biological fluids by desorption/ionization mass spectrometry with nanoporous silicon microparticles (2015)

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a high throughput analytical technique capable of detecting low molecular weight analytes, including illicit drugs, and with potential applications in forensic toxicology as well as athlete and workplace testing, particularly for biological fluids (oral fluids, urine and blood). However, successful detection of illicit drugs using SALDI-MS often requires extraction steps to reduce the inherent complexity of biological fluids. Here, we demonstrate an all-in-one extraction and analytical system consisting of hydrophobically functionalized porous silicon microparticles (pSi-MPs) for affinity SALDI-MS of prescription and illicit drugs. This novel approach allows for the analysis of drugs from multiple biological fluids without sample preparation protocols. The effect of pSi-MP size, pore diameter, pore depth and functionalization on analytical performance is investigated. pSi-MPs were optimized for the rapid and high sensitivity detection of methadone, cocaine and 3,4-methylenedioxymethamphetamine (MDMA). This optimized system allowed extraction and detection of methadone from spiked saliva and clinical urine samples. Furthermore, by detecting oxycodone in additional clinical saliva and plasma samples, we were able to demonstrate the versatility of the pSi-MP SALDI-MS technique.
Distributed and autonomous resource allocation for femto-cellular networks (2012)

A distributed and autonomous technique for resource and power allocation in femto-cell networks is presented. Resource blocks (RBs) are assigned to the user(s) in each cell individually without coordination between base stations (BSs). The allocatability of each resource is determined using only local information: · the user's required rate; · the quality of the desired signal; · the level of interference incident on each RB; and · the frequency-selective fading on each RB. Using fuzzy logic, these inputs are combined to determine which RBs are most suitable for allocation in a particular cell. A comprehensive study of this system yields a staggering system performance improvement over state-of-the-art interference coordination techniques.
YAPISAL İNŞACILIK KAPSAMINDA SURİYE SORUNU (2012)

ayaklanmaya kar uluslararas gelitirilen inisiyatif vaka almas olarak seilmitir
Antibacterial activity of long-chain alcohols against Streptococcus mutans (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntibacterial activity of long-chain alcohols against Streptococcus mutansIsao. Kubo, Hisae. Muroi, and Aya. KuboCite this: J. Agric. Food Chem. 1993, 41, 12, 2447–2450Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/jf00036a045https://doi.org/10.1021/jf00036a045research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Review of A23.3-94 simplified method of shear design and comparison with results using shear friction (1998)

A review of the so-called simplified method of shear design described in CSA A23.3-94 "Design of concrete structures" shows that the method is not simple. The designer is required to check numerous equations and limits. The resulting relation between stirrup spacing and shear strength is found to be an extremely complex line resulting from the intersection of seven separate surfaces. A shear friction model has been developed which seems to predict the shear strength of beams rather well. Stirrups and longitudinal reinforcement provide a clamping force thereby increasing the friction force which can be transferred across a crack along a potential failure plane. This model is based on the shear strength after cracking so that no diagonal tension strength is included. The shear friction model has been used as the basis for determining approximate equations for maximum stirrup spacing. A comparison of these approximate shear friction predictions with those using the simplified method indicates a high degree of correlation but many important differences. It seems that shear design can be clarified as well as simplified by adoption of the shear friction approach.Key words: reinforced concrete, shear, shear friction, shear tests, stirrup spacing.
Reviews of Books (1957)

Journal Article Reviews of Books Get access The Journals of Captain James Cook. Vol. i: The Voyage of tht Endeavour, 1768–1771. Additional volume of charts and views. Edited by J. C. BEAGLEHOLE. ( Cambridge University Press, for Hakluyt Society, 1955.) J. N. L. BAKER J. N. L. BAKER Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXII, Issue CLXXXII, January 1957, Pages 133–136, https://doi.org/10.1093/ehr/LXXII.CLXXXII.133 Published: 01 January 1957
A dynamic bandwidth resource allocation based on neural networks in euroskyway multimedia satellite system (2003)

Abstract Advanced traffic management based on the dynamic resource assignment allows a broadband satellite system such as euroskyway (ESW) to dynamically assign the resources of connections. The mechanisms of the dynamic assignment exploit variations of burstiness exhibited by real time and non‐real time variable bit rate traffic sources to perform an optimized resource redistribution. The efficiency of the dynamic bandwidth allocation capability (DBAC) depends on the accuracy of the traffic source description; inaccurate assessment of the arrival process will cause an overhead and a degraded utilisation of system resources. In this paper a flexible traffic burstiness predictor for dynamic bandwidth resource allocation based on neural network is presented. The approach is able to perform an online estimation of expected resource requests implementing traffic resource assignment by using a sub‐symbolic adaptive representation of the traffic source. The achieved results prove that the flexible approach is more effective than the ones based on fixed schemes designed using analytical traffic source description when applied on the satellite terminal ESW system component. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Konstruktion eines wassergekühlten Schweißkopfes zum Verschweißen von bis zu 20 mm breiten Stahlbandelektroden unter Schutzgas (1977)

Die in Vorversuchen durchgeführten Schweißungen, bei denen weder eine ausreichende Qualität der Auftragschweißungen noch eine gute Reproduzierbarkeit gewährleistet werden konnte, ergaben für das Verfahren ohne Verwendung von Steuermagneten die Notwendigkeit, den vorhandenen Schweißautomaten mit einem speziellen Kopf auszustatten, der es erlaubt, bis zu 20 mm breite Stahlbandelektroden zu verwenden. Dabei muß eine gute Kontaktierung, eine ausreichende Kühlung und eine geeignete Schutzgasführung gegeben sein, um Auftragschweißungen erstellen zu können, die den gestellten Anforderungen weitgehend genügen. Als Anforderungen stehen zunächst ein möglichst geringer und gleichmäßiger Einbrand, eine zum Plattieren geeignete Raupengeometrie und -oberfläche und die Vermeidung von Spritzern und zu großen Abbrandverlusten im Raum.
Silencing echoes on the telephone network (1980)

Echo of a trasmitted signal can occur in the telephone network and is sometimes a disturbing phenomenon. Various methods of echo control have been used for over 50 years but recent introduction of transmission delays in excess of 300 ms, over satellite circuits, has resulted in a general reexamination of suppression methods. This led to development of the echo canceller. Adaptive echo cancellation is accomplished by automatically synthesizing a replica of the echo path response, convolving the incoming signal with the replica and subtracting the resulting echo estimate from the echo path output. Transmission is not thereby interrupted in any way and two-way information transmission proceeds normally with little or no echo. Detailed mathematical formulations for the convergence properties of such devices allow understanding of the effects of various hardware configurations and input signal properties. Echo cancellers may be applied to the network in a number of ways and the development of a VLSI canceller chip promises inexpensive implementation of these applications. Worldwide tests have shown the effectiveness of cancellation methods for satellite transmission.
Proteomic Differences Between Hepatocellular Carcinoma and Nontumorous Liver Tissue Investigated by a Combined Gel-based and Label-free Quantitative Proteomics Study (2013)

Proteomics-based clinical studies have been shown to be promising strategies for the discovery of novel biomarkers of a particular disease. Here, we present a study of hepatocellular carcinoma (HCC) that combines complementary two-dimensional difference in gel electrophoresis (2D-DIGE) and liquid chromatography (LC-MS)-based approaches of quantitative proteomics. In our proteomic experiments, we analyzed a set of 14 samples (7 × HCC versus 7 × nontumorous liver tissue) with both techniques. Thereby we identified 573 proteins that were differentially expressed between the experimental groups. Among these, only 51 differentially expressed proteins were identified irrespective of the applied approach. Using Western blotting and immunohistochemical analysis the regulation patterns of six selected proteins from the study overlap (inorganic pyrophosphatase 1 (PPA1), tumor necrosis factor type 1 receptor-associated protein 1 (TRAP1), betaine-homocysteine S-methyltransferase 1 (BHMT)) were successfully verified within the same sample set. In addition, the up-regulations of selected proteins from the complements of both approaches (major vault protein (MVP), gelsolin (GSN), chloride intracellular channel protein 1 (CLIC1)) were also reproducible. Within a second independent verification set (n = 33) the altered protein expression levels of major vault protein and betaine-homocysteine S-methyltransferase were further confirmed by Western blots quantitatively analyzed via densitometry. For the other candidates slight but nonsignificant trends were detectable in this independent cohort. Based on these results we assume that major vault protein and betaine-homocysteine S-methyltransferase have the potential to act as diagnostic HCC biomarker candidates that are worth to be followed in further validation studies.
Transcriptomic landscape of circulating mononuclear phagocytes in Langerhans cell histiocytosis at the single-cell level (2021)

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm caused by aberrant activation of the mitogen-activated protein kinase (MAPK) pathway. Circulating myeloid cells from patients often carry disease-associated mutations and can be differentiated into langerinhigh LCH-like cells in vitro, but their detailed immune-phenotypic and molecular profiles are lacking and could shed key insights into disease biology. Here we recruited 217 pediatric LCH patients and took blood and tissue samples for BRAFV600E analysis. Immune-phenotyping of the circulating Lin-HLA-DR+ immune population in 49 of these patients revealed that decreased frequency of plasmacytoid dendritic cells was significantly linked to disease severity. By single-cell RNA sequencing of samples from 14 patients, we identified key changes in expression of RAS-MAPK-extracellular signal-regulated kinase (ERK) signaling-related genes and transcription factors in distinct members of the mononuclear phagocyte system in the presence of BRAFV600E. Moreover, treatment of patients with the BRAF inhibitor dabrafenib resulted in MAPK cascade inhibition, inflammation prevention, and regulation of cellular metabolism within mononuclear phagocytes. Finally, we also observed elevated expression of RAS-MAPK-ERK signaling-related genes in a CD207+CD1a+ cell subcluster in skin. Taken together, our data extend the molecular understanding of LCH biology at single-cell resolution, which might contribute to improvement of clinical diagnostics and therapeutics, and aid in the development of personalized medicine approaches.
Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity (2022)

Steroid receptor RNA activator gene (SRA1) emerges as a player in pathophysiological responses of adipose tissue (AT) in metabolic disorders such as obesity and type 2 diabetes (T2D). We previously showed association of the AT SRA1 expression with inflammatory cytokines/chemokines involved in metabolic derangement. However, the relationship between altered adipose expression of SRA1 and the innate immune Toll-like receptors (TLRs) as players in nutrient sensing and metabolic inflammation as well as their downstream signaling partners, including interferon regulatory factors (IRFs), remains elusive. Herein, we investigated the association of AT SRA1 expression with TLRs, IRFs, and other TLR-downstream signaling mediators in a cohort of 108 individuals, classified based on their body mass index (BMI) as persons with normal-weight (N = 12), overweight (N = 32), and obesity (N = 64), including 55 with and 53 without T2D. The gene expression of SRA1, TLRs-2,3,4,7,8,9,10 and their downstream signaling mediators including IRFs-3,4,5, myeloid differentiation factor 88 (MyD88), interleukin-1 receptor-associated kinase 1 (IRAK1), and nuclear factor-κB (NF-κB) were determined using qRT-PCR and SRA1 protein expression was determined by immunohistochemistry. AT SRA1 transcripts' expression was significantly correlated with TLRs-3,4,7, MyD88, NF-κB, and IRF5 expression in individuals with T2D, while it associated with TLR9 and TRAF6 expression in all individuals, with/without T2D. SRA1 expression associated with TLR2, IRAK1, and IRF3 expression only in individuals with obesity, regardless of diabetes status. Furthermore, TLR3/TLR7/IRAK1 and TLR3/TLR9 were identified as independent predictors of AT SRA1 expression in individuals with obesity and T2D, respectively. Overall, our data demonstrate a direct association between the AT SRA1 expression and the TLRs together with their downstream signaling partners and IRFs in individuals with obesity and/or T2D.
Increased Vulnerability to Focal Ischemic Brain Injury in Human Apolipoprotein E4 Knock-In Mice (2003)

Accumulating evidence suggests that among the 3 human apolipoprotein E (apoE) isoforms encoded by the human APOE gene, the e4 allele may act to exacerbate brain damage in humans and animals. This study aimed to compare the isoform-specific vulnerability conferred by human apoE to ischemic brain damage, using mice expressing human apoE isoforms (apoE2, apoE3, or apoE4) in place of mouse apoE, produced by the gene-targeting technique in embryonic stem cells (knock-in, KI). Homozygous human apoE2 (2/2), apoE3 (3/3), or apoE4 (4/4) KI mice were subjected to permanent focal cerebral ischemia by a modified intraluminal suture method. Twenty-four h thereafter, brain damage, (as estimated by infarct volume and neurologic deficit) was significantly worse in 4/4 KI mice versus 2/2 or 3/3 KI mice (p < 0.001 for each comparison), with no significant differences between 2/2 and 3/3 KI mice. Immunohistochemistry for human apoE expression revealed similar apoE distribution with no significant difference in the immunostaining intensity among the 3 lines of KI mice. Notably. increased expression of human apoE was detected in neurons and astrocytes in the peri-infarct area, and a punctate expression pattern was evident in the border between the infarct and peri-infarct areas in all KI mice subjected to ischemia. Taken together, our results show that apoE affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 > apoE3 = apoE2) in genetically engineered mice.