gebhart/patrepeval huggingface dataset:
Indium(iii), antimony(iii) and bismuth(iii) dihalide complexes with tridentate, anionic thio- and selenosemicarbazonato ligands (2011)

Some indium(III), antimony(III) and bismuth(III) dihalide complexes containing deprotonated, tridentate thio- and selenosemicarbazone ligands were prepared and were fully characterized by spectroscopic methods. In addition, the crystal structures of some of the compounds were obtained. TGA and DSC analyses were carried out on selected samples to assess their suitability as single-molecule precursors for metal selenide nanomaterials.
Perfil microbiológico da infecção nosocomial numa unidade de cuidados intensivos respiratórios. (1994)

In 1987, in the Respiratory Intensive Care Unit of Santa Maria Hospital we developed a nosocomial surveillance program with specially created software that provides knowledge of NI in the ICU at any moment. The information gathered along the time is particularly useful in the correlation of the risk factors, the most frequent microorganisms and in the institution of empiric antibiotic therapy. Out of 2528 patients admitted in our ICU for the last 6 years (87/92), 10% had bacteriologically identified NI. Almost (93%) of them had occurred in mechanically ventilated patients, which corresponds to 20.7% NI in those patients. The gram-negative appeared in 63.37%, with the predominance of Enterobacteriaceae. From the gram-positives the most frequent were Staphylococcus spp. Their meticiline resistance was worrisome. NI patients had significantly higher severity and therapeutic intervention scores. Mechanical ventilation period was 4 fold higher and mortality 2.5 times higher in the patients with this complication.
Electronic Power Steering Compensating Control for Influence of Vehicle Dynamics on Steering Torque (2009)

&lt;div class="htmlview paragraph"&gt;The frequency response of steering effort torque changes according to the influence of vehicle dynamics. To help enhance feel, a new electronic power steering (EPS) control has been constructed. As the control can be achieved by the addition of a viscosity control with a filter to existing EPS systems, its structure is simple and easily installed. Actual vehicle tests have been performed to verify that the control is capable of enhancing convergence without adversely affecting response during steering.&lt;/div&gt;
Blockade of the Ras–Extracellular Signal–Regulated Kinase 1/2 Pathway Is Involved in Smooth Muscle 22α–Mediated Suppression of Vascular Smooth Muscle Cell Proliferation and Neointima Hyperplasia (2010)

These findings suggest that high expression of SM22 alpha inhibits cell proliferation via reduction of the response to mitogen stimuli in VSMCs and provide a novel mechanism by which VSMCs maintain their contractile phenotype and resist mitogenic stimuli in an SM22 alpha-dependent manner.
Clinical trial of interactive and videotaped educational interventions reduce infection, reactive depression, and rehospitalizations for sepsis in patients on home parenteral nutrition (2003)

The IEVI reduced CR-BSIs and reactive depression and increased problem solving with professionals. IEVI use also can result in fewer hospitalizations and improved quality of life. Long-term improvement did not occur for reactive depression and problem-solving outcomes because patients used these less often.
A haptic guidance system for Computer-Assisted Surgical Training using virtual fixtures (2016)

A simple and robust fuzzy logic controller with a forbidden region virtual fixture is proposed for a haptic guidance system developed to assist in simulation-based training of laparoscopic surgery. A surgical training system that involves human in the control loop is discussed. It uses a controller which adjusts control outputs for different trainees based on their skill level. The system involves virtual fixtures to improve human manipulation tasks inherent in this problem domain. The proposed controller cooperates with a heuristic-based scaling factor modifier to make such adjustments. The experimental results illustrate the feasibility and effectiveness of the proposed haptic guidance system.
(S)-2-Amino-2-(2-chlorophenyl)cyclohexanone (2011)

The crystal structure of the title compound, C(12)H(14)ClNO, was determined in order to confirm that the chiral center of the mol-ecule has an S configuration. The cyclo-hexa-none ring adopts a chair conformation. The 2-chloro-phenyl ring is slightly twisted from the axial C-N bond, with a N-C-C-C torsion angle of -5.7 (2)°. In the crystal, an inter-molecular N-H⋯O hydrogen bond links adjacent mol-ecules into an infinite chain, which propagates in the b-axis direction.
Abstract 3963: Deep serial analysis of the TCR/BCR CDR3 adaptome repertoire in peripheral blood of pancreatic cancer patients in a randomized study of neoadjuvant chemotherapy with or without autophagy inhibition (2019)

Abstract Pancreatic cancer has a paucity of dendritic cells and almost no T lymphocytes. Here, we used Next Generation Sequencing following dimer avoidance multiplexed PCR (DAM-PCR) immune repertoire to study the characteristics and diversity of the TCR repertoire among PDAC (Pancreatic Ductal Adenocarcinoma) patients who underwent chemotherapy with or without Hydroxycholoroquine followed by surgical extirpation. We sequenced the TCR α,β,γ, and δ chains and the B-cell receptor (BCR) heavy chain (IgH) complementary-determining region 3 (CDR3) repertoire in peripheral blood mononuclear cells (PBMCs) from 10 PDAC patients before (Pre-chemo) and after chemotherapy (Post-chemo) and following operation (Postop). The distribution of CDR3, VD indel, and DJ indel lengths were similar among the Prechemo, Postchemo and Postop groups. The TCR repertoire diversity of PDAC patients was much lower compared to healthy donors (HD). The diversity index (D50) of TCR α and β’s in PDAC patients who received HCQ during chemotherapy was less than in patients without HCQ (p&amp;lt;.05). TRBV expression increased and some public sequences diminished at individual time points following chemotherapy and postop. Full analysis of an ongoing study will be presented. Citation Format: Yue Wang, Michael T. Lotze. Deep serial analysis of the TCR/BCR CDR3 adaptome repertoire in peripheral blood of pancreatic cancer patients in a randomized study of neoadjuvant chemotherapy with or without autophagy inhibition [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3963.
Comparison of Lipoprotein Based Insulin Resistance Score and Traditional Risk Factors in Adolescents with Obesity (2020)

Click the PDF icon to download the abstract.
Worldwide differential GPS for Space Shuttle landing operations (2002)

A worldwide differential Global Positioning System (WWDGPS) is viewed as an effective method of offering continuous high-quality navigation worldwide. The concept utilizes a network with as few as 33 ground stations to observe most of the error sources of GPS and to provide error corrections to users on a worldwide basis. The WWDGPS real-time GPS tracking concept promises a threefold or fourfold improvement in accuracy for authorized dual-frequency users, and in addition maintains an accurate and current ionosphere model for single-frequency users. A real-time global tracking network also has the potential to reverse declarations of 'poor health' of marginal satellites, increasing the number of satellites in the constellation And lessening the probability of GPS navigation outage. For Space Shuttle operations, the use of WWDGPS-aided P-code equipment promises performance equal to or better than other current landing guidance systems in terms of accuracy and reliability. This performance comes at significantly less cost to NASA, which will participate as a customer in a system designed as a commercial operation serving the global civil navigation community.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
June 1987 annual report : development of an integrated mobile robot system at Carnegie Mellon (2018)

Robotics Institute
High-Contrast Visualization and Differentiation of Microphase Separation in Polymer Blends by Fluorescent AIE Probes (2017)

The visualization of microphase separation in immiscible polymer blends is of great academic and industrial significance as the phase-separated structures are directly associated with the properties and performances of the blend materials and ultimately influence the corresponding product quality. However, conventional techniques for detecting microphase separation are generally expensive and time-consuming with troublesome and even destructive sample preparation procedures. Complicated and highly material-dependent chemical reactions or interactions are often involved in some characterization approaches. In this work, we demonstrated a simple, fast, and powerful method for high-contrast visualization and differentiation of micrometer-sized phase separation in polymer blends using luminogens with aggregation-induced emission characteristics (AIEgens) as fluorescent probes. This method relies on the sensitive fluorescence response of AIEgens to the change of environmental rigidity and polarity and operates based on the mechanisms of “restriction of intramolecular motions” and “twisted intramolecular charge transfer”. The working principle indicates that this visualization strategy is applicable to a wide scope of polymer blends comprised of components with different rigidities and/or polarities.
Vagus nerve stimulation reduces cocaine seeking and alters plasticity in the extinction network (2016)

Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction learning reduces rates of relapse. Here we used vagus nerve stimulation (VNS) to induce targeted synaptic plasticity to facilitate extinction of appetitive behaviors and to reduce relapse. Rats self-administered cocaine and were given VNS during extinction. Relapse to drug-seeking was assessed in a cued reinstatement session. We used immunohistochemistry to measure changes in the expression of the phosphorylated transcription factor cAMP response-element binding protein (pCREB) in the PFC and the basolateral amygdala (BLA), which regulate cue learning and extinction. In vivo recordings of evoked field potentials measured drug- and VNS-induced changes in metaplasticity in the pathway from the PFC to the BLA. VNS-treated rats showed improved rates of extinction and reduced reinstatement. Following reinstatement, pCREB levels were reduced in the IL and BLA of VNS-treated rats. Evoked responses in the BLA were greatly reduced in VNS-treated rats, and these rats were also resistant to the induction of LTD. Taken together, these results show that VNS facilitates extinction and reduces reinstatement. Changes in the pathway between the PFC and the amygdala may contribute to these beneficial effects.
Effect of intake of linoleic acid and α‐linolenic acid levels on conversion into long‐chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs (2012)

A study was conducted to determine the effect of two levels of linoleic acid (LA) intake at either high or low α-linolenic acid (ALA) intake on their conversion and subsequent deposition into long-chain (20-22 C-atoms) polyunsaturated fatty acids (LC PUFA) in muscle and backfat in growing pigs. In a 2 × 2 factorial arrangement, 32 gilts from 8 litters were assigned to one of four dietary treatments, varying in LA and ALA intakes. Low ALA and LA intakes were 0.15 and 1.31 g/(kg BW(0.75) /day), respectively, and high ALA and LA intakes were 1.48 and 2.65 g/(kg BW(0.75) /day) respectively. There was a close positive relation between intake of ALA and the concentration of ALA in backfat and in intramuscular fat. Dietary ALA did not affect the concentration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), but increased docosapentaenoic acid (DPA) in backfat. High ALA intake did not significantly affect DHA but significantly increased EPA, 20:3 n-3 and DPA concentrations in intramuscular fat. The n-3 LC PUFA proportion in backfat was increased from approximately 1-3%, which may be useful to enrich meat with these fatty acids. The effect of ALA intake on n-3 LC PUFA was suppressed by LA intake. Dietary ALA suppressed the concentration of n-6 LC PUFA in blood plasma by more than 50%. When compared at equal incremental dose, the inhibiting effect of ALA on blood arachidonic acid was stronger than the stimulating effect of LA as precursor.
Design and performance of waveguide E-plane HTSC insert filters (2003)

A design theory is described for waveguide E-plane inductive strip filters that takes the high-order mode interaction, and the finite thickness of metal with a dielectric substrate underneath into account. The main idea was to use superconducting material, instead of metal, in the design of inductive strip insert filters. A design method is introduced for this purpose, and high-T/sub c/ superconducting (HTSC) films serve as perfect conductors. An X-band bandpass filter was fabricated with HTSC materials. The measured results of the HTSC bandpass filter are presented and compared with the CAD-predicted filter performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A novel pattern of distributed low-rate denial of service attack disrupts internet routing (2012)

Recently identified low-rate TCP-targeted DoS attacks can cause failures of Border Gateway Protocol sessions and route flappings without being detected by current defense mechanisms. Deliberately constructed Distributed low-rate DoS attacks can even generate surge of updates throughout the Internet. As this new breed of attacks needs a low-rate time gap between adjacent pulses, this time gap waste large number pulses to form other attack flows. In this paper, we investigate the possibility and methods of employing the time gap to evoke other attack flows against target network. Simulations show that this method can exponentially reduce the number of nodes and therefore lower the cost of the attack when attacking multiple BGP sessions simultaneously. Experiments show that the integrated attack is efficient in causing BGP session resets, delayed routing convergence and seriously impacting routing stability and network reachability. We also proposed the attack scheme and defense mechanisms of this kind of attacks.
Application of h‐BN particles using Ca‐assisted carbothermal reduction nitridation to high‐thermal‐conductive resin/h‐BN composites (2023)

Abstract Hexagonal boron nitride (h‐BN) particles exhibit high thermal conductivity and are promising fillers for resin filling. However, h‐BN particles are plate‐like particles with thermal anisotropy in the planar and thickness directions. Therefore, their applications are limited due to low thermal conductivity in the direction of the thickness of a resin sheet filled with h‐BN particles. In this study, we control the size and thickness of h‐BN particles using carbothermal reduction nitridation (CRN), which involves the carbothermic reduction of boric oxide in an N 2 gas atmosphere and develop them into resin sheets. In CRN using a CaO promoter, a novel method is developed to control the shape, size, and thickness of h‐BN particles. Using h‐BN particles grown in the thickness direction, we have successfully provided resin sheets with high thermal conductivity.
STAT5a Activation Mediates the Epithelial to Mesenchymal Transition Induced by Oncogenic RhoA. (2003)

The involvement of Rho GTPases in signal transduction pathways leading to transcription activation is one of the major roles of this family of GTPases. Thus, the identification of transcription factors regulated by Rho GTPases and the understanding of the mechanisms of their activation and its biological outcome are of great interest. Here, we provide evidence that Rho GTPases modulate Stat5a, a transcription factor of the family of signal transducers and activators of transcription. RhoA triggers tyrosine phosphorylation (Y696) of Stat5a via a JAK2-dependent mechanism and promotes DNA-binding activity of Stat5a. Tyrosine phosphorylation of Stat5a is also stimulated physiologically by lysophosphatidic acid (LPA) in a Rho-dependent manner. Simultaneously, RhoA reduces serine phosphorylation of Stat5a at both serine residues S726 and S780, resulting in a further increase of activity as defined by mutagenesis experiments. Furthermore, serine dephosphorylation of Stat5a by RhoA does not take place by down-modulation of either JNK1, MEK1, or p38 MAP kinases, as determined by transfection experiments or chemical inhibition of both MEK1, p38, and JNK serine kinases. Thus, RhoA regulates Stat5a via tyrosine phosphorylation and via a yet to be determined novel down-modulating pathway that involves serine dephosphorylation. Finally, we provide evidence for a role of Stat5a in RhoA-induced epithelial-to-mesenchymal transition with concomitant increase in vimentin expression, E-cadherin down-regulation, and cell motility.
Idiopathic Myelofibrosis Developing Isolated Granulocytic Sarcoma with der (1;7)(q10; p10) After Splenectomy and Finally Transforming to Acute Myelogenous Leukemia (2000)

A 47-year-old female with idiopathic myelofibrosis developed isolated granulocytic sarcoma with der (1; 7)(q10; p10) after splenectomy, followed by acute myelogenous leukemia. The patient had myelofibrosis since 22 years of age, received splenectomy at 47 years, and developed isolated submandibular granulocytic sarcoma, 8 months later. Although the initial tumor disappeared after irradiation, recurrent tumors selectively appeared in the areas of operative scars. She subsequently developed blastic transformation with der (1; 7)(q10; p10), and the blasts were refractory to different chemotherapy. This case is very rare in the following aspects: the onset of myelofibrosis occurred at a relatively young age; isolated granulocytic sarcoma after splenectomy preceded the transformation to acute leukemia; and the subcutaneous tumors developed in areas of operative scars.
Real-Time Prognosis for Metastatic Thyroid Carcinoma Based on 2-[18F]Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography Scanning (2006)

FDG-PET scanning is a simple, expensive, but powerful means to restage thyroid cancer patients who develop subsequent metastases, assigning them to groups that are either at low (FDG negative) or high (FDG positive) risk of cancer-associated mortality. We propose that the aggressiveness of therapy for metastases should match the FDG-PET status.
Book Review: Classical Light Scattering from Polymer Solutions. By P. Kratochvil (1988)

<em>Angewandte Chemie International Edition in English</em> is one of the prime chemistry journals in the world, publishing research articles, highlights, communications and reviews across all areas of chemistry.
Technology for producing carbon field emitters (1985)

This paper describes methods for producing field emitters from carbon filaments. Coating of Ni and two-layer coatings of Ni-Mo with a thickness of 10-40 um are applied to the carbon filaments by electrochemical deposition so that they can be spot welded to a metal holder. A technology for attaching carbon filaments with a refractory adhesive composition is also described. Field emitters with point radius of curvature of 0.2-0.4 um are made from three types of carbon filament.
Network subsystem design (1993)

It is argued that the bandwidth of the CPU/memory data path on workstations will remain within the same order of magnitude as the network bandwidth delivered to the workstation. This makes it essential that the number of times network data traverses the CPU/memory data path be minimized. Evidence which suggests that the cache cannot be expected to significantly reduce the number of data movements over this path is reviewed. Hardware and software techniques for avoiding the CPU/memory bottleneck are discussed. It is concluded that naively applying these techniques is not sufficient for achieving good application-to-application throughput; they must also be carefully integrated. Various techniques that can be integrated to provide a high bandwidth data path between I/O devices and application programs are outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Kinematics of the Heart: Finite Element and 3D Time-Resolved Phase Contrast Magnetic resonance Imaging (2002)

During the cardiac cycle, the myocardium (heart muscle) undergoes large elastic deformations as a consequence of the active muscle contraction along the muscle :fibers and their relaxation, respectively. A four-dimensional (4D) description (three spatial dimensions + time) of the kinematics of the myocardium would bring increased understanding of the mechanical properties of the heart and may be of interest in assessing regional myocardial function.The heart is a complex three-dimensional structure and therefore velocity components in three directions are necessary to accurately describe the velocities in the myocardium. The phase contrast MRI pulse sequence used in this work provides velocity vectors in a 3D spatial grid covering the entire heart throughout the cardiac cycle. The suggested method provides the strain-rate tensor in each measured voxel and time frame of the cardiac cycle, calculated from the velocity field. Coordinates for the measured voxels,obtained from the velocity data, defme the deformation of a finite element mesh. This mesh is used for calculation of myocardial strain.The method presented in this thesis enables automated delineation of the borders of the myocardium, definition of a parametric fmite element mesh and calculation of 4D myocardial strain and strain-rate throughout the cardiac cycle. The suggested visualization method displays the full tensors, including the main direction of deformation or deformation rate without any assumptions of myocardial motion directions in the calculations.
Breast cancer stem cells programs: enter the (non)-code (2016)

Breast tumors exhibit a hierarchical cellular organization driven by several subpopulations of cancer stem cells (CSCs). These breast CSC subpopulations are able to infinitely self-renew and to differentiate, giving rise to tumor heterogeneity. Accumulating evidence show that breast CSCs resist conventional therapies and i`nitiate tumor relapse. The development of anti-CSCs therapies may therefore greatly improve patient survival. A better elucidation of molecular circuitries involved in stemness would offer new relevant targets. Noncoding RNAs, especially microRNAs and long noncoding RNAs, are regulators of cell identity and are notably found deregulated in breast CSCs. This review will focus on noncoding RNAs involved in CSCs biology during breast cancer initiation, maintenance, therapeutic resistance and metastatic progression. Potential clinical applications using noncoding RNAs as biomarkers or therapies will be discussed.
Supplementary Table 8 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity (2023)

&lt;p&gt;XLS file, 3148K, Compiled expression array and ChIP-on-chip data.&lt;/p&gt;