gebhart/patrepeval huggingface dataset:
Supplementary Figure from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome (2023)

Supplementary Figure from DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome
Tutorial on Practical Prediction Theory for Classification (2005)

We discuss basic prediction theory and it&amp;apos;s impact on classification success evaluation, implications for learning algorithm design, and uses in learning algorithm execution. This tutorial is meant to be a comprehensive compilation of results which are both theoretically rigorous and practically useful. There are two important implications...
Observation of the Λb0→Λc+K+K−π− decay (2021)

The Λb0→Λc+K+K−π− decay is observed for the first time using a data sample of proton-proton collisions at centre-of-mass energies of s=7 and 8TeV collected by the LHCb detector, corresponding to an integrated luminosity of 3fb−1. The ratio of branching fractions between the Λb0→Λc+K+K−π− and the Λb0→Λc+Ds− decays is measured to beB(Λb0→Λc+K+K−π−)B(Λb0→Λc+Ds−)=(9.26±0.29±0.46±0.26)×10−2, where the first uncertainty is statistical, the second systematic and the third is due to the knowledge of the Ds−→K+K−π− branching fraction. No structure on the invariant mass distribution of the Λc+K+ system is found, consistent with no open-charm pentaquark signature.
Biosynthesis of l-Phenylalanine and l-Tyrosine in the Actinomycete Amycolatopsis methanolica (1995)

Auxotrophic mutants of the actinomycete Amycolatopsis methanolica requiring l-Phe or l-Tyr were isolated and identified as strains lacking prephenate dehydratase (strain GH71) or arogenate dehydrogenase (strain GH70), respectively. A. methanolica thus employs single pathways only for the biosynthesis of these aromatic amino acids. Anion-exchange chromatography of extracts revealed two peaks with Phe as well as Tyr aminotransferase (AT) activity (Phe/Tyr ATI and Phe/Tyr ATII) and three peaks with prephenate AT activity (Ppa ATI to Ppa ATIII). Phe/Tyr ATI and Ppa ATI coeluted and appear to function as the A. methanolica branched-chain amino acid AT. Ppa ATII probably functions as the aspartate AT. Mutant studies showed that Phe/Tyr ATII is the dominant AT in l-Phe biosynthesis and in l-Tyr catabolism but not in l-Tyr biosynthesis. Biochemical studies showed that Ppa ATIII is highly specific for prephenate and provided evidence that Ppa ATIII is the dominant AT in l-Tyr biosynthesis.
Hematopoietic regulatory factors produced in long-term murine bone marrow cultures and the effect of in vitro irradiation (1984)

The nature of hematopoietic regulatory factors elaborated by the adherent (stromal) cells of long-term murine bone marrow cultures and the effect of in vitro stromal irradiation (XRT) on the production of these factors was investigated. Using an in situ stromal assay employing a double layer of semisolid agar, it was possible to demonstrate stromal elaboration of at least two colony-stimulating activities, ie, granulocyte/macrophage colony-stimulating activity (G/M- CSA) and megakaryocyte colony-stimulating activity (Meg-CSA). Exposure of the stroma to XRT resulted in dose-dependent elevations of both activities that correlated inversely with total myeloid cell mass as determined by concurrent reductions in total supernatant cell recoveries from irradiated cultures. Mixture experiments that combined control and irradiated stroma revealed that the hematopoietically active control stroma could block detection of XRT-related G/M-CSA elevations. These data implicate a local negative feedback mechanism in the regulation of hematopoiesis. Antiserum directed against purified L cell colony-stimulating factor (CSF) reduced granulocyte/macrophage colony formation in the target layer but did not effect the increased Meg-CSA. While a radioimmunoassay for L-cell type CSF was unable to detect significant differences in concentrated media from control and irradiated cultures, bioassays of these media revealed XRT-related G/M- CSA elevations. These results indicate that the G/M-CSA elaborated in these cultures is immunologically distinct from the Meg-CSA produced, and although distinct from L cell CSF, the G/M-CSA is crossreactive with the L cell CSF antiserum. Morphologic, histochemical, and factor VII antigen immunofluorescent studies were performed on the stromal cell population responsible for production of these stimulatory activities. In addition to “fat” cells, the stromal cells remaining after XRT were composed of two predominant cell populations. These included a major population of acid phosphatase and nonspecific esterase-positive macrophage-like cells and a minor population of factor VII antigen negative epithelioid cells.
Minireview: MicroRNA Function in Pancreatic β Cells (2014)

MicroRNAs are small noncoding ribonucleotides that regulate mRNA translation or degradation and have major roles in cellular function. MicroRNA (miRNA) levels are deregulated or altered in many diseases. There is overwhelming evidence that miRNAs also play an important role in the regulation of glucose homeostasis and thereby may contribute to the establishment of diabetes. MiRNAs have been shown to affect insulin levels by regulating insulin production, insulin exocytosis, and endocrine pancreas development. Although a large number of miRNAs have been identified from pancreatic β-cells using various screens, functional studies that link most of the identified miRNAs to regulation of pancreatic β-cell function are lacking. This review focuses on miRNAs with important roles in regulation of insulin production, insulin secretion, and β-cell development, and will discuss only miRNAs with established roles in β-cell function.
Role of interleukin 1 in antigen-specific T cell proliferation. (1984)

The role of interleukin 1 (IL 1) in human antigen-specific T cell proliferation was examined. Nylon wool-purified T cells proliferated in the presence of autologous monocytes (Mo.) pulsed for 18 h with tetanus toxoid (TT) antigen (Mo.TT). Irradiation of Mo.TT with ultraviolet (UV) light (72 J/m2) abolished their capacity to support T cell proliferation and drastically reduced their capacity to secrete IL 1 after stimulation with Staphylococcus albus. The defect in antigen presentation induced by UV irradiation of Mo.TT was reversed in a dose-dependent manner by the addition of two different preparations containing human interleukin 1 (IL 1). The first preparation consisted of supernatants of Mo. stimulated with Con A for 18 hr and in which Con A activity was blocked by alpha-D-methyl-mannoside (Mo.-Con A-Sup). The second preparation consisted of human IL 1 partially purified from supernatants of human peripheral blood mononuclear cells stimulated with S. albus. This IL 1 copurified with human leukocyte pyrogen (LP) and was termed IL 1/LP. Both IL 1-containing preparations enhanced the response of C57BL/6 mouse thymocytes to phytohemagglutinin. A rabbit antibody to human IL 1/LP inhibited the capacity of T cells to proliferate in response to Mo.TT and inhibited the capacity of Mo.-Con A-Sup to reconstitute the T cell response to UV-irradiated Mo.TT. IL 1/LP was not necessary for T cells to recognize the immunogenic moiety presented by Mo., because monolayers of UV-irradiated Mo.TT were equivalent to monolayers of unirradiated MO.TT in their capacity to adsorb TT-reactive T cells specifically. Furthermore, the addition of rabbit antibody to IL 1/LP did not interfere with the capacity of UV-irradiated Mo.TT to adsorb TT-reactive T cells. The results obtained in this study indicate that IL 1 is involved in optimal antigen-driven proliferation of human T lymphocytes.
Evaluation of three algorithms for ab initio determination of three-dimensional shape from one-dimensional solution scattering profiles (2003)

In recent years, several methods for determining ab initio three-dimensional shape from solution scattering have been reported. In order to clarify the common and unique features of these programs, we verified the stability and convergence of three major programs, 'dammin', 'saxs3d' and 'dalai_ga', for experimental data. Two different types of samples were prepared: troponin-C and denatured apomyoglobin. With all of the three programs, the stability of the models and fitting among different runs increased as the diameters of the packing spheres were reduced in the region larger than 4Å. In the case of troponin-C, the models obtained always bore a striking resemblance irrespective of different runs of three algorithms. The averaged model coincided with the averaged structure of multiple nuclear magnetic reasonance models. In the case of denatured apomyoglobin, the best models from different algorithms also have similar features. These results suggest that if the molecule contains highly mobile portions, the resulting model corresponds to the averaged structure.
The Development of Cortical Sensitivity to Visual Word Forms (2011)

The ability to extract visual word forms quickly and efficiently is essential for using reading as a tool for learning. We describe the first longitudinal fMRI study to chart individual changes in cortical sensitivity to written words as reading develops. We conducted four annual measurements of brain function and reading skills in a heterogeneous group of children, initially 7-12 years old. The results show age-related increase in children's cortical sensitivity to word visibility in posterior left occipito-temporal sulcus (LOTS), nearby the anatomical location of the visual word form area. Moreover, the rate of increase in LOTS word sensitivity specifically correlates with the rate of improvement in sight word efficiency, a measure of speeded overt word reading. Other cortical regions, including V1, posterior parietal cortex, and the right homologue of LOTS, did not demonstrate such developmental changes. These results provide developmental support for the hypothesis that LOTS is part of the cortical circuitry that extracts visual word forms quickly and efficiently and highlight the importance of developing cortical sensitivity to word visibility in reading acquisition.
The Not so Sweet Side of Added Sugar (2021)

Consumption of sugar in its many forms produces energy required by the brain and body yet can also confer harmful health effects. Chronic sugar ingestion can lead to the development of Type 2 diabetes, metabolic syndrome, cardiovascular illness and neurodegenerative disorders. Although there is a wealth of knowledge about the negative human health effects of added dietary sugar, there is limited understanding about the effects on the bacteria enriched in the human digestive tract. This human microbiome is highly complex, diverse, and has been linked to disease and poor health.
Fast falsification based on symbolic bounded property checking (2006)

Symbolic property verification is an increasingly popular debugging method based on Binary Decision Diagrams (BDDs). The lack of optimization of the state space search is often responsible for the excessive growth of the BDDs. In this paper we present an accelerated symbolic property verification by means of a new guiding technique that automatically finds the set of interesting variables by exploiting the property and the transition relation of a design. Our property based state space guiding can substantially speed up the verification process. The heuristic picks up the interesting state or the input variables automatically and utilizes them in guiding the state space traversal. This guiding approach is a novel one as it is automatic, efficient and stable for fast falsification. Furthermore it does not degrade as much for full validation.
The Effect of Product Regulation on Business Global Competitiveness: A Contingency Approach (1995)

This paper focuses on product regulation, which is one important type of regulation that influences business firms. We develop a theoretical model that describes the effect of product regulation on the global competitiveness of business. Special emphasis is given to the contingency effects of several variables on the relationship between product regulation and business global competitiveness. We derive three propositions about these contingency effects, and also discuss higher-order interactions that may occur between the contingency. The overall thrust of our argument is to question the universality of the assumption that regulation is detrimental to business competitiveness.
A Collaborative Support Tool for Creativity Learning: Idea Storming Cube (2007)

Creativity plays an important role in many learning activities but how to enhance creativity with the support of modern computer tools deserves further studies. In this paper, we propose a game-based collaborative creativity support system called Idea storming cube to support creative thinking and help a user form a perspective-shift thinking habit. The system analyzes the knowledge acquired from the history of user inputs and compares it with the ideas possessed by the domain expert and other users in the current brainstorming group. The system is designed to provide user-, goal- and context-sensitive supports with this mechanism that stimulates more divergent thinking. We have implemented the proposed game with a magic-cube-like HCI for collaborative idea generation. A case study for preliminary evaluation of the system is also reported in this paper.
The assessment of advanced pre-treatment chains. TO2 Advanced pre-treatment of biomass; Task A3 (2016)

The overall objective of the TO2 project ‘Advanced pre-treatment of biomass’ was to design optimal energy-driven refinery chains for the susta inable valorization of non-woody biomass to biobased commodities. Therefore optimal combination s need to be found of upstream biorefining and the production of high-quality (sol id) energy carriers from a broad spectrum of non-woody biomass streams. Task A3. within this TO2 project focused on modelling chains and performing an economic evaluation of these chains. Three cases of biomass chains were modelled and evaluated in this report.
[Interim recommendations concerning the functioning of nursing homes (Central Board for Public Health)]. (1982)

In june 1982 the Advisory Committee of the Central Board of Health presented its latest report on the functioning of nursing homes in the Netherlands. This publication is actually the Committee's fourth report in succession, the third report having been submitted in 1972. When seeking renewed advice, the Minister of Health and Environmental Control required an answer to eight very concrete questions, centering on the conception that the quality of life in nursing homes should be greatly improved without involving any additional expenditure. It is considered an asset of the Advisory Committee that their recommendations do not require the tapping of other financial sources. The fact, however, that no contribution was made to the improvement of the living conditions in nursing homes, the very question so urgently raised by the Minister, is looked upon as a great disadvantage. In brief, the latest report contains no new ideas! A repetition of the arguments quoted ten years ago can hardly have been the object the Minister had in mind, when seeking renewed advice. It goes without saying that a new report will have to be submitted on the qualitative functioning of nursing homes. Time presses! It will be necessary for a Committee of wise men to be appointed, willing to put forward innovating ideas and being able to defend them with enthusiasm.
An ultralow-noise high-speed CMOS linescan sensor for scientific and industrial applications (2004)

This paper describes a 2048x1 linear image sensor implemented in a 0.35 &mu;m 4M1P CMOS process that uses a low fixed pattern noise capacitive transimpedance amplifier (LFPN CTIA) pixel architecture. The pixel also includes circuitry for reducing 1/f noise, correlated double sampling, electronic shuttering, and a horizontal anti-blooming drain. High speed non-destructive readout of the sensor is achieved by using a hierarchical readout structure with two output ports. Using a JTAG interface the sensor can be programmed to operate in multiple readout modes. In the fastest readout mode, ROI, the sensor achieves 90Mpixel/sec (43.4Klines/sec) with 14e- RMS read noise. In the lowest noise mode, MRDI, with 13x oversampling of each pixel the sensor achieves 2.7Klines/sec with 1.2e- RMS read noise.
Pressure Swing Adsorption (2002)

ADVERTISEMENT RETURN TO ISSUECommentaryNEXTPressure Swing AdsorptionShivaji SircarView Author Information Air Products and Chemicals, Inc., Allentown, Pennsylvania 18195Cite this: Ind. Eng. Chem. Res. 2002, 41, 6, 1389–1392Publication Date (Web):February 9, 2002Publication History Published online9 February 2002Published inissue 1 March 2002https://pubs.acs.org/doi/10.1021/ie0109758https://doi.org/10.1021/ie0109758brief-reportACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views12944Altmetric-Citations214LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adsorption,Animal feed,Atmospheric chemistry,Separation science,Zeolites Get e-Alerts
Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023)

Dietary methionine restriction, defined as reduction of methionine intake by around 80%, reproducibly decreases tumor growth and synergizes with cancer therapies. Here, we combined dietary methionine restriction with immune checkpoint inhibitors in a model of colon adenocarcinoma. <i>In vitro</i> , we observed that methionine restriction increased the expression of MHC-I and PD-L1 in both mouse and human colorectal cancer cells. We also saw an increase in the gene expression of STING, a known inducer of type I interferon signaling. Inhibition of the cGAS-STING pathway, pharmacologically or with siRNA, blunted the increase in MHC-I and PD-L1 surface and gene expression following methionine restriction. PD-L1 expression was also This indicated that the cGAS-STING pathway in particular, and interferon in general, is playing a role in the immune response to methionine restriction. We then combined dietary methionine restriction with immune checkpoint inhibitors targeted against CTLA-4 and PD-1 in a MC38 colorectal cancer tumor model in C57BL/6 mice. The combination treatment was five times more effective at reducing tumor size than immune checkpoint inhibition alone in males. We noted sex differences in the response to dietary methionine restriction for the MC38 tumor model in C57BL/6 mice. Finally, we observed an increase in PD-L1 protein expression in MC38 tumors from animals who were fed a methionine-restricted diet. Furthermore, the distribution of CD8 staining changed from mostly peripheric in the controls, to intratumoral in the methionine-restricted tumors. MHC-I, which has a high basal expression in MC38 cells, was highly expressed in all tumors. These results indicate that methionine restriction improves the response to immune checkpoint inhibitors in mice, and that this improvement is associated with the cGAS-STING pathway and interferon signaling.
Defining a remote village typology to improve the technical standard for off-grid electrification system design (2018)

Access to affordable and clean energy to the rural communities in the developing nations has been the pivotal aim on a global stage. Universal access to reliable and clean electricity to the ever-increasing global population has directed the governmental bodies to switch towards a decentralized energy access approach. However, the efforts of the nodal agencies around the world have not yielded the desired results. A knowledge gap in terms of a village typology that corresponds to an inappropriate electrification system selection has been identified. A suitable typology for remote villages in developing countries is subsequently defined for rural electrification system classification. Also, amendments to the technical standard IEC/TS 62257-2 for rural electrification are suggested, which is decisive in the techno-economic assessments of microgrids in such contexts.
Using Inertial Sensors for Position and Orientation Estimation (2017)

Microelectromechanical system (MEMS) inertial sensors have become ubiquitous in modern society. Built into mobile telephones, gaming consoles, virtual reality headsets, we use such sensors on a daily basis. They also have applications in medical therapy devices, motion-capture filming, traffic monitoring systems, and drones. While providing accurate measurements over short time scales, this diminishes over longer periods. To date, this problem has been resolved by combining them with additional sensors and models. This adds both expense and size to the devices. This tutorial focuses on the signal processing aspects of position and orientation estimation using inertial sensors. It discusses different modelling choices and a selected number of important algorithms that engineers can use to select the best options for their designs. The algorithms include optimization-based smoothing and filtering as well as computationally cheaper extended Kalman filter and complementary filter implementations. Engineers, researchers, and students deploying MEMS inertial sensors will find that this tutorial is an essential monograph on how to optimize their designs.