gebhart/patrepeval huggingface dataset:
Fully stabilized optical frequency comb with sub-radian CEO phase noise from a SESAM-modelocked 15-µm solid-state laser (2011)

We report the first full stabilization of an optical frequency comb generated from a femtosecond diode-pumped solid-state laser (DPSSL) operating in the 1.5-μm spectral region. The stability of the comb is characterized in free-running and in phase-locked operation by measuring the noise properties of the carrier-envelope offset (CEO) beat, of the repetition rate, and of a comb line at 1558 nm. The high Q-factor of the semiconductor saturable absorber mirror (SESAM)-modelocked 1.5-µm DPSSL results in a low-noise CEO-beat, for which a tight phase lock can be much more easily realized than for a fiber comb. Using a moderate feedback bandwidth of only 5.5 kHz, we achieved a residual integrated phase noise of 0.72 rad rms for the locked CEO, which is one of the smallest values reported for a frequency comb system operating in this spectral region. The fractional frequency stability of the CEO-beat is 20‑fold better than measured in a standard self-referenced commercial fiber comb system and contributes only 10(-15) to the optical carrier frequency instability at 1 s averaging time.
Homo Ludens: A Study of the Play-Element in Culture. (1951)

The sociology of culture seeks to locate the world of the arts within the broader context of the institutions and ideology of society. This wide-ranging set covers the sociology of dance, literary taste and cinema. Taking into account also the cultural context of play and child-rearing, this is important reading for students and researchers in Cultural Studies.
Advances in real-time magnetic resonance imaging of the vocal tract for speech science and technology research (2016)

Real-time magnetic resonance imaging (rtMRI) of the moving vocal tract during running speech production is an important emerging tool for speech production research providing dynamic information of a speaker's upper airway from the entire mid-sagittal plane or any other scan plane of interest. There have been several advances in the development of speech rtMRI and corresponding analysis tools, and their application to domains such as phonetics and phonological theory, articulatory modeling, and speaker characterization. An important recent development has been the open release of a database that includes speech rtMRI data from five male and five female speakers of American English each producing 460 phonetically balanced sentences. The purpose of the present paper is to give an overview and outlook of the advances in rtMRI as a tool for speech research and technology development.
Reliability of large conductive polymer flip chip assemblies for multichip modules (MCMs) (2002)

Work has already been reported on two thermoset adhesives for solder replacement flip chip attachment using both gold and copper flip chip test vehicles. The one drawback with any thermoset material is that rework is difficult should there be a failure after assembly so precise alignment is necessary. Thermoplastic material offers the advantage of reworking. This paper discusses work with thermoplastic epoxy. However, the new material being tested is so different from the previously tested conductive pastes that new fabrication and assembly procedures had to be developed. Initial work has begun in evaluating the performance of thermoplastic epoxy. Not only is this thermoplastic paste viscous enough to prevent smearing during the stencil printing process, but also rigid enough to create 2 mil height bumps by stencil printing twice onto the same substrate. Some disadvantages of this paste is that processes after the bumps are applied must be performed at low temperatures and the paste appears to be more compatible with palladium than gold.
Rapid Genotyping for Tumor Necrosis Factor-α (TNF-α) −863C/A Promoter Polymorphism That Determines TNF-α Response (2004)

Tumor necrosis factor-α (TNF-α) plays a central role in orchestrating the inflammatory response (1). Accordingly, blocking TNF-α activity has become a standard treatment of several inflammatory diseases (2)(3). TNF-α production shows high interindividual variations, which have been assigned mainly to inherited factors (4). Several genetic polymorphisms related to TNF-α synthesis have been detected in the TNF gene (5)(6). The −308 promoter polymorphism was found to affect TNF-α production by some authors (7) but not by others (8). Similar inconsistencies have been found for the association of this polymorphic site with susceptibility to and/or outcome of sepsis (8)(9). The Nco I polymorphism located within the first intron of the lymphotoxin A (LTA) gene was reported to be associated with TNF-α plasma concentrations (8). In a recent report, de Jong et al. (10) found no relationship between ex vivo TNF-α production on endotoxin stimulation of human whole blood and +489, −238, and −376 single-nucleotide polymorphisms or TNFa microsatellites of the TNF-α gene (10). Thus, the genetic factors determining the TNF-α response to infection are still poorly defined.

Recently, Skoog et al. (11) identified a C/A exchange at position −863 of the TNF-α gene promoter and found higher transcriptional activity of the C allele in reporter gene assays. This polymorphic site was found to be associated with thyroid-associated ophthalmopathy (12), Crohn disease(13), juvenile rheumatoid arthritis (14), and the lumbar spine area (15).

In the present study we sought to determine the association of the −863 TNF-α promoter polymorphism with the TNF-α production capacity of human blood cells. We describe a new real-time PCR assay with specific fluorescently labeled hybridization probes for genotyping for this polymorphism. We also genotyped samples for other polymorphic sites implicated in TNF-α production capacity and evaluated the possible existence of linkage …
Periodically poled 5mm-thick MgO-doped congruent LiNbO3 for high power/energy wavelength conversion (2005)

5mm-thick MgO-doped congruent LiNbO3 crystal was poled periodically with 32.1µm period by temperature-elevated field poling technique. The quasi-phase matching structure was evaluated by second-harmonic generation measurement using d 31-coefficient. The improved periodic structure compared to our 3mm-thick device was obtained.
Determinants and prognostic value of pulmonary arterial pressure in patients with chronic heart failure (2010)

Using a definition of PASP > 45 mmHg, 7% of the patients with HF have PAH, which is associated with worse LV function, MR, and prognosis. Whether PAH is a target for therapy in this population remains to be elucidated.
Impact of radiotherapy on surgical repair and outcome in patients with rectourethral fistula (2013)

Few patients with radiation-induced rectourethral fistula avoid permanent colostomy and urostomy. In contrast, most patients with nonradiation-related fistulae undergo successful perineal repair without permanent faecal and urinary diversion.
A Heterodyne Optical Fiber Current Sensor Based on a Nanowire-Grid In-Line Polarizer (2012)

A heterodyne optical fiber current sensor based on a nanowire-grid (NWG) in-line polarizer is proposed. The NWG is a one-dimension Au grating fabricated on a fiber tip by focused ion beam machining. Because the grating pitch is far smaller than the wavelength of the incident light, it works like an in-line transflective fiber polarizer with both the transmission and reflection light power being measured simultaneously. Based on this unique feature, an all-fiber optical current sensor is demonstrated. The heterodyne measurement makes it withstand light power variations showing good sensing stability. As an all-fiber sensor, discrete and bulky optical components are saved, making it more reliable in practical applications.
Enterprise Cloud Deployment: Integration Patterns and Assessment Model (2016)

The term "cloud" is increasingly used in association with the trend of using IT services supplied by a third party over the Internet to support business, consumers, and general users. Although the cloud can be confusing because of the breadth of services made available, the technology has clearly gained significant momentum in all industries. This article presents an approach for assessing the suitability for building or migrating enterprise-scale IT applications to the cloud. Because integration is a key factor influencing cloud deployment, the authors describe several patterns as a basis for enabling enterprise cloud solutions. Building on the integration patterns, the authors propose a method for an initial evaluation of the risk and effort required to move new and existing applications to a cloud service provider by assessing a range of additional factors that influence the complexity of cloud deployment. Hence, this article presents a set of patterns and processes intended to serve as a practical guide for technologists deploying cloud-based solutions.
Carbon Networks Based on 1,5-Naphthalene Units. Synthesis of 1,5-Naphthalene Nanostructures with Extended π-Conjugation (2002)

The synthesis and spectroscopic characterization of nanometer-sized conjugated molecules of 5-X-naphthylethynyl (X= NO(2), NMe(2)) units with precise length and constitution have been carried out. A new extended pi-conjugated 5-nitronaphthyl family was synthesized by palladium-catalyzed cross-coupling reaction between the protected 5-iodonaphthylethynyl 5a and 1-ethynyl-5-nitronaphthalene 9, or the resulting ethynyl compound 11 and the 1-iodo-5-nitronaphthalene 3. Catalytic oxidative dimerization of the terminal acetylene compounds permits the isolation of the corresponding 1,3-butadiyne derivatives 16-18, with the nitro groups at the ends of the conjugation, in excellent yields. A new family of conjugated 5-nitro-(naphthylethynyl)-[5-(N,N-dimethylamino)]naphthalene (20-22), was also synthesized by palladium-catalyzed cross-coupling reaction between 5-iodo-N,N-dimethylnaphthalene-1-amine (19) with the appropriate terminal acetylene (9, 11, and13 respectively). Compounds 20-22 show a fluorescence emission and also exhibit a charge-transfer absorption in the visible spectrum. X-ray structure of 20 confirms a centrosymmetric dimer association with an interplanar distance of 3.43 A, and the naphthalene rings adopt an anti conformation around the Ctbd1;C triple bond.
Method — Intra-bone marrow transplantation of hematopoietic stem cells in non-human primates: long-term engraftment without conditioning (2004)

Founded in 1683 in Leiden, the Netherlands, Brill is a leading international academic publisher in the Humanities, Social Sciences, International Law, and Biology. With offices in the Netherlands, Germany, Austria, the USA and Asia, Brill today publishes more than 360 journals and 2,000 new books and reference works each year as well as a large number of databases and primary source research collections.
PERANCANGAN APLIKASI ANDROID KONSULTASI KESEHATAN MENGGUNAKAN REACT NATIVE (2022)

Konsultasi kesehatan merupakan suatu layanan kesehatan yang bertujuan sebagai tindak pencegahan dalam menghentikan perkembangan berbagai penyakit terhadap pasien yang memiliki faktor resiko. Konsultasi pada saat ini, merupakan kegiatan yang sulit untuk dilakukan terlebih pada saat jam kerja maupun jam sibuk lainnya. Kemudian pada masa pandemi covid-19 membuat berbagai klinik tidak dapat di kunjungi guna mencegah penyebaran virus covid-19. Pada permasalahan tersebut, maka diterapkan penggunaan aplikasi konsultasi kesehatan dengan mengapliakasikan segala sistem di dalamnya. Aplikasi tersebut bermanfaat dalam memberikan informasi terkait kesehatan baik fisik, mental, maupun gizi seseorang. Dalam perkembangan teknologi informasi yang sangat pesat khususnya aplikasi mobile sehingga perancangan aplikasi android konsultasi kesehatan dirasa penting untuk dikembangkan guna memantau kesehatan pada setiap individu tanpa harus pergi ke klinik. Saat ini masyarakat sudah terbiasa mencari informasi kesehatan di internet, tapi sumbernya sering tidak valid. Lebih baik cari sumber dengan dokter-dokter yang kompeten melalui aplikasi android konsultasi kesehatan tersebut. Metode yang digunakan pada pengembangan aplikasi android konsultasi kesehatan ialah metode RAD (Rapid Application Development). Aplikasi dirancang menggunakan kerangka kerja React Native dan berjalan pada sistem operasi Android. Layanan Firebase yang digunakan pada aplikasi ini terdiri dari Firebase Authentication, Firebase Realtime Database dan Firebase Storage. Bedasarkan penelitian dan hasil implementasi yang dilakukan, aplikasi android konsultasi kesehatan dapat memberikan solusi yang efisien dan mudah untuk digunakan dalam melakukan layanan konsultasi kesehatan
A new path-gain/delay-spread propagation model for digital cellular channels (1997)

We derive a statistical model for the distribution of RMS delay spread (/spl tau//sub rms/) within a cellular environment, including the effects of base-to-mobile distance, environment type (urban, suburban, rural, and mountainous areas), and the correlation between delay spread and shadow fading. We begin with intuitive arguments that /spl tau//sub rms/ should be lognormally distributed at any given distance d; that the median of this distribution should grow as some (weak) power of d and that the variation about the median should be negatively correlated with shadow fading gain. We then present empirical evidence, drawn from a wide array of published reports, which gives strong support to these conjectures. Finally, we combine our findings with the widely used model for path gain in a cellular environment. The result is a compact statistical model for the joint distribution of path gain and delay spread. The model lends itself readily to Monte Carlo simulation and is useful for performance studies of cellular systems with bandwidths up to tens of kilohertz.
Phase II study of docetaxel and oxaliplatin in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer (NSCLC). (2010)

e18022 Background: Docetaxel (D) is active in advanced NSCLC. Bevacizumab (B) enhances conventional chemotherapy with increased response rate and prolonged survival. The study objective is to evaluate efficacy and safety of D and oxaliplatin (O) in combination with B as first-line therapy in patients (pts) with non-squamous IIIB/IV NSCLC. Methods: Pts with non-squamous, IIIB/IV NSCLC, measurable disease, Performance Status (PS) ≤ 2, and adequate organ function were treated with D 70 mg/m2, O 100 mg/m2 and B 15 mg/kg, intravenously on day 1 in a q3 week cycle up to 6 cycles. B was continued up to a total of one year unless disease progression or unacceptable toxicity occurred. Prophylactic G-CSF was not required. Uncontrolled hypertension and untreated brain metastasis were excluded. Assessments included tumor response (every 6 weeks) and toxicity. Results: Fifty-three pts were enrolled (median age, 62 years; range 36, 77). There were 72% male, 79% Caucasian, 89% stage IV, 94% adenocarcinoma and 6% PS = 2. Among 52 treated pts, a median of 6 cycles were received per pt. 40% patients received at least one cycle of B monotherapy as maintenance. Dose reduction/delay occurred in 19 pts (36%). Nine (17%) pts discontinued treatment due to adverse events. The confirmed overall response rate (ORR) was 30.2% in 16 pts including one complete response (CR). 20 pts (38%) had stable disease (SD). The clinical benefit (CR+PR+SD) was 68%. Median progression free survival was 5.6 months (95% CI: 2.9, 7.9). Median time to treatment failure was 4.7 months (95% CI: 2.9, 5.6). Median overall survival was 14 months (95% CI: 10.3, 18.1). The commonly reported grade (G) 3/4 adverse events included neutropenia (15%) diarrhea (14%), fatigue (12%), and dehydration (10%). One G3 neuropathy (1.9%) and no G3/4 hemoptysis were reported. Four deaths occurred during treatment period and one (pneumonia) was considered treatment related. Conclusions: The docetaxel, oxaliplatin and bevacizumab regimen showed favorable clinical activity in this setting, comparable with historical results of antiangiogenic therapy. This triplet has shown an acceptable toxicity profile. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration sanofi-aventis Genentech, sanofi-aventis Genentech, sanofi-aventis
Studies on organic fluorine compounds. XVIII. On the mechanism of the conversion of trifluoromethyl group to amino group on a quinoline ring. (1975)

The mechanism for a novel reaction of a trifluoromethyl group as a leaving group is confirmed. Reaction of 2-(heptafluoro-n-propyl) quinoline with sodium amide gave 2-aminoquinoline, which shows that a perfluoroalkyl group could behave as a leaving group in some SNAr reactions. Tris (trifluoromethyl)-s-triazine gave a 1, 4-ammonia adduct, which shows that the reaction passed through addition-elimination mechanism.
LogBoy meets FilterGirl--a toolkit for multivariant movies (1994)

Thesis (M.S.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1994.
Tibial rotation in single‐ and double‐bundle ACL reconstruction: a kinematic 3‐D in vivo analysis (2011)

Both "anatomic" single- and double-bundle ACL reconstruction adequately restore tibial rotational excursion in a human, "in vivo" kinematic model. As knee stability measurements by in vivo kinematic 3-D analysis more accurately represent actual knee loading during activities, the results of this study might better correlate with functional outcome after ACL reconstructions compared with static knee stability tests or ex vivo laboratory experiments. In such, the results of this dynamic study do not support the theoretical advantage of a double-bundle ACL reconstruction over an "anatomic" single-bundle ACL reconstruction.
Effects of Intravenous Patient Controlled Analgesia with Morphine, Meperidine or Fentanyl on Bowel Function after Gastrectomy (2003)

Background: Although opioids are widely used and effectively control postoperative pain, they contribute to the delayed recovery of gastrointestinal function. The aim of this study was to investigate the effects of intravenous patient controlled analgesia (iv PCA) with morphine, meperidine or fentanyl on postoperative bowel function. Methods: Sixty ASA physical status I or II adult patients who were scheduled for elective gastrectomy were randomly allocated to morphine, meperidine, or fentanyl groups. After administering an initial bolus dose of morphine 5 mg, meperidine 25 mg, or fentanyl 50g at OR, each iv PCA pump was started at PACU. The following program was used: morphine group-concentration 3 mg/ml, basal infusion rate 1.5 mg/hr, bolus 1.5 mg, meperidine group-concentration 15 mg/ml, basal infusion rate 7.5 mg/hr, bolus 7.5 mg, fentanyl group-concentration 30g/ml, basal infusion rate 15g/hr, bolus 15g. The lockout time was 15 min in all groups. Postoperative pain at rest was evaluated with NRS (0-100) 6, 24, 48 and 72 hr after the end of surgery. Times from end of surgery to the passage of the first flatus were recorded. Results: Pain scores were comparable at rest in the three groups over the three postoperative days. Time from the end of surgery to the first postoperative flatus was 116.6 13.2 hr in morphine group, 97.5 17.6 hr in meperidine group, and 91.8 19.1 hr in fentanyl group. Time from the end of surgery to first postoperative flatus was significantly longer in the morphine group than in the other two groups (P = 0.002, P = 0.000). Side effects were not significantly different among the groups. Conclusions: Meperidine or fentanyl were found to have an advantage in terms of bowel function over morphine when used for iv PCA after gastrectomy.
Ultrasonic analysis of precision-engineered acoustically active lipospheres produced by microfluidic (2009)

The development of a ¿magic bullet¿ that could carry therapeutic dose of drug to a target organ or tumor with high specificity is the ideal goal of targeted drug delivery. Acoustically active drug carriers must possess a layer with drug-carrying capacity, similar to a liposome, yet at the same time, they must have a core with significantly different density and compressibility than the surrounding media - such as a gas. Factors such as consistent response to acoustic pulses and consistent loading per particle are important characteristics for reliable delivery. Here, we utilize microfluidic technology to precision engineer acoustically-active drug delivery vehicles. Microfluidic multi-layer flow focusing enables production of acoustically active lipospheres (AALs) with nearly identical diameter. We perform ultrasonic interrogation of these multi layer vehicles as they are produced to determine their acoustic activity and diameter consistency. Acoustic response from lipospheres was measured to be on the same order of magnitude as responses from thin-wall lipid shelled contrast agents, indicating the oil layer did not produce notable damping effects on the acoustic scattering. We hypothesize that based on nearly identical echo signatures, that it will be easier to optimize ultrasound radiation-force mediated concentration and acoustically-mediated drug release to affect all AALs similarly.
A review of NASA's propulsion programs for aviation (1978)

A review of five NASA engine-oriented propulsion programs of major importance to civil aviation are presented and discussed. Included are programs directed at exploring propulsion system concepts for (1) energy conservation subsonic aircraft (improved current turbofans, advanced turbofans, and advanced turboprops); (2) supersonic cruise aircraft (variable cycle engines); (3) general aviation aircraft (improved reciprocating engines and small gas turbines); (4) powered lift aircraft (advanced turbofans); and (5) advanced rotorcraft.
Genetic analysis of goldsinny wrasse reveals evolutionary insights into population connectivity and potential evidence of inadvertent translocation via aquaculture (2017)

The salmon industry is heavily dependent on wrasse for delousing infected fish. The goldsinny wrasse is numerically the most important, and each year, millions are harvested from the wild and transported large distances into fish farms. Population genetic knowledge is required to sustainably exploit this species. Here, 1051 goldsinny wrasses from 16 locations across Scandinavia, the British Isles, and Spain were genotyped with 14 microsatellite and 36 SNP markers. Within-population genetic diversity decreased towards north, and a genetic break was observed across the North Sea. Samples from Northern Norway differed from rest of the Scandinavian samples, and samples from the British Isles differed from the Spanish ones. Within Scandinavia, isolation-by-distance was detected. Observed genetic patterns fitted well with expectations derived from oceanographic drift simulations. A sample from mid-Norway deviated from these patterns however, and was genetically very similar to southern Scandinavian samples. We conclude that the population structure of this species is primarily determined by the opposing evolutionary forces of passive drift, limited adult migration and spawning-site fidelity, whereas the deviation in isolation-by-distance observed in mid-Norway is potentially caused by inadvertent translocations of wrasse from southern Scandinavia via current aquaculture practise. Inclusion of outlier loci gave greater resolution, suggesting that diversifying selection may also affect population structuring among goldsinny wrasses.
High Cutoff Membrane to Reduce Systemic Inflammation Due to Differentiation Syndrome: A Case Report (2014)

HCO-CVVHD should be explored as a part of treatment in systemic inflammation states other than sepsis (e.g., differentiation syndrome). Furthermore, its immunomodulatory effects could be particularly useful in immunocompromised patient treated with corticosteroids.