gebhart/patrepeval huggingface dataset:
Nonmyeloablative allogeneic stem cell transplantation as immunotherapy for pancreatic cancer and other solid tumors (2004)

2539 Background: For the treatment of advanced and metastatic disease, conventional anti-tumor therapies such as chemotherapy and radiotherapy have been largely unsuccessful. Particularly in cases of advanced pancreatic cancer, prognosis is extremely poor. Recently, nonmyeloablative allogeneic stem cell transplantation (NST) has been successfully applied for treatment of solid tumors such as renal cell carcinoma. We performed NST in order to establish the role of this immunotherapy in the treatment strategy for Japanese patients with pancreatic cancer and other solid tumors. Methods: Japanese patients under the age of 65 with advanced disease resistant against chemotherapy and/or radiotherapy were enrolled in this pilot study. Fludarabine (Flu) based reduced intensity conditioning was performed prior to the infusion of G-CSF mobilized peripheral blood stem cells obtained from HLA- matched sibling donors. Donor chimerism of both T cells and mononuclear cells (MNC) was determined by PCR-based analysis of polymorphic short tandem repeat markers. In order to investigate the mechanism by which NST elicits an anti-tumor effect, serum levels of TNFα were measured by ELISA in four cases of pancreatic cancer. Results: Outcome of patients is given in the table below. Complete T cell chimerism was achieved within 100 days in all cases. Elevation of TNFα compared to baseline level was noted in patients #5 and #7, who achieved CR and SD, respectively. Serum levels of TNFα were unchanged in patients #6 and #8, who had progressive disease.Conclusions: Successful engraftment and anti-tumor effect of NST were observed. TNFα has a possible immunological role during the clinical course of NST. No significant financial relationships to disclose.
An evolutionary design-support-system with structural representation (2002)

We propose a tool creation support system using evolutionary techniques. Here, a tool is defined as an object which consists of multiple parts and is encoded to a tree structure. The proposed system is composed of two phases: the fundamental-parts-generation-phase where each fundamental part is generated, and the structuring-phase where the generated parts are combined. In each phase, evolutionary techniques which utilize a user's evaluations as decision of fitness are employed. Therefore it is possible to obtain desirable shapes for users. We have implemented this system on the O2 computer, and have evaluated the proposed system. As a result, it is confirmed that various novel shapes can be obtained.
Temporal planning with semantic attachment of non-linear monotonic continuous behaviours (2015)

Non-linear continuous change is common in realworld problems, especially those that model physical systems. We present an algorithm which builds upon existent temporal planning techniques based on linear programming to approximate non-linear continuous monotonic functions. These are integrated through a semantic attachment mechanism, allowing external libraries or functions that are difficult to model in native PDDL to be evaluated during the planning process. A new planning system implementing this algorithm was developed and evaluated. Results show that the addition of this algorithm to the planning process can enable it to solve a broader set of planning problems.
Relation between Fatty Acid Composition of Cellular Phospholipids and the Excretion of L-Glutamic Acid by a Glycerol Auxotroph of Corynebacterium alkanolyticum (1973)

Relation between fatty acid composition of cellular phospholipids and the excretion of L-glutamic acid was investigated using Corynebacterium alkanolyticum GL–21 (a glycerol auxotroph). When grown on n-hexadecane, the proportion of unsaturated fatty acids was higher in L-glutamic acid-accumulating cells than in L-glutamic acid-nonaccumulating cells. When grown on fructose or acetic acid, the reverse relation was observed. Moreover, cells containing no oleic acid produced L-glutamic acid from n-pentadecane. These results suggest that the membrane permeability to L-glutamic acid is not always controlled by the cellular content of unsaturated fatty acids.
Organic vapor sensors based on SAW resonator and organic films (1997)

The majority of investigations of SAW devices used as chemical sensors are based on delay line oscillators. However, SAW resonator oscillator offers some advantages over the SAW delay line oscillator for its higher stability. In the incipient stage of fabricating gas sensors based upon SAW resonator, taking detection of organic vapor as an example, the analysis method that combines the SAW theory with organic film technology has been adopted to give an intensive insight into the responses of two-port SAW resonator coated with LB-film and cast-film after exposure to organic vapors.
Use of Gabapentin for Perioperative Pain Control – a Meta‐Analysis (2007)

Gabapentin improves the analgesic efficacy of opioids both at rest and with movement, reduces analgesic consumption and opioid-related adverse effects, but is associated with an increased incidence of sedation and dizziness.
Analysis of neonatal heart rate variability by a microprocessor-based on-line system (1985)

The effects of different rejection logic limits on the results of analysis of neonatal heart rate variability from electrocardiograms by a microprocessor-based system were studied on fourteen infants after normal labor and on ten infants after elective cesarean section. In addition to the infant's movements and crying, two further main sources of error in the calculation of variability indices were detected: premature beats and problems in the shape of QRS complexes in a neonatal electrocardiogram. No noteworthy problem was observed in the calculation of the interval index (II), which describes the long term variability of heart rate. In the calculation of the differential indices (DI), which describe the short term component of heart rate, distorted QRS complexes created very high DIs when the rejection logic was ten beats per minute (bpm). When stricter rejection limits were used (five bpm), the DI values even in these cases fell within the normal range. The DI values calculated using a rejection limit of five bpm were always lower than those calculated using a rejection limit of ten bpm, but the reference values of neonatal II and DI after normal labor were similar to those presented previously using a rejection limit of ten bpm. In conclusion, the neonatal electrocardiogram appears to be a noisy signal, comparable with the abdominal fetal electrocardiogram, and strict rejection limits are useful in processing it for indices of variability.
The Effect of Inhibitors on the Efflux of Betacyanin and Aerobic Respiration in Red Beet Tissue (1970)

Summary. The effects of various concentrations of cyanide, azide, and 2,4-dinitrophenol on 02 consumption and efflux of betacyanin from red beet disks were determined over a 4 hour test period. During the first hour the inhibitors produced only slight increases in betacyanin efflux, irrespective of inhibitor concentration and rate of 02 consumption. At incubation periods longer than 1 hour it was suggestive that higher inhibitor concentrations caused a larger efflux of betacyanin than the same inhibitor at a lower concentration. However, inhibitor comparison studies showed no direct relationship between aerobic respiration and efflux of betacyanin. It is s~ggested that the increase in the efflux of betacyanin and the decrease in respiration are two independent processes and it appears that cellular metabolism may not be directly involved in the maintenance of membrane integrity, however, further work is needed to verify this hypothesis.
Professional Java E-Commerce (2001)

From the Publisher:
J2EE can integrate services from a variety of vendors and legacy systems, i.e. applications and data that have been inherited from languages, platforms, and techniques before the current technology. The fact that J2EE is cross platform, scalable and portable means that server-side Java will play a very large part in the evolution of business systems and services. 
Building on the success of Professional Java Server J2EE edition (1861004656), this comprehensive compedium will provide the Java developer with the information they need to develop scalable and powerful e-commerce sites. Its ambitious coverage includes the broad sweep of B2C, B2B and M-Commerce. The book will start with an overview of the business considerations required when developing E-Commerce solutions, will move on to review the underlying technologies that are used in developing Java solutions. It will then move onto illustrate how Java can be used to address each of the listed E-Commerce problem domains through a combination of generic discussions and real-world case studies.
Coordinate elevation of serum markers in ovarian cancer but not in benign disease (1991)

Effective screening for occult ovarian cancer will require a strategy that is both sensitive and specific. Preliminary data suggest that CA 125 is elevated at diagnosis in a majority of patients with ovarian cancer. Although CA 125 is sufficiently specific to prompt its evaluation as one component of a strategy to detect ovarian cancer in postmenopausal women, a further improvement in specificity would facilitate cost-effective screening. In an attempt to develop a more specific screening strategy, multiple markers were assayed in a panel of sera from 47 patients with ovarian cancer and in a separate panel of sera from 50 individuals with benign disease whose serum CA 125 levels exceeded 35 U/ml. Among the patients with ovarian cancer, elevations of CA 125 (greater than 35 U/ml) were observed in 91%, CA 15-3 (greater than 30 U/ml) in 57%, TAG 72 (greater than 10 U/ml) in 49%, placental alkaline phosphatase (PLAP) in 25%, human milk fat globule protein (HMFG) 1 in 77%, HMFG2 in 62%, and NB/70K in 57%. Among the 50 sera selected from patients with benign disease, CA 125 was more than 35 U/ml in 100% and more than 65 U/ml in 42%. Among those patients with benign disease and elevated CA 125, NB/70K was elevated in 62%, HMFG1 in 26%, and HMFG2 in 12%, whereas TAG 72 and CA 15-3 were elevated in only 6% and 2%, respectively. In addition PLAP appeared promising; elevated enzyme levels were not found in the benign disease group. Among patients with ovarian cancer with CA 125 levels more than 35 U/ml, either TAG 72 or CA 15-3 was elevated in 77%. In the false-positive group, only 6% had elevations of one or the other marker. The CA 125 levels in cancer patients were, however, substantially greater than in patients with benign disease. If sera from patients with ovarian cancer were diluted to a range comparable to that found in benign disease, at least one of the two confirmatory tests was elevated in 63% of the samples from the malignant cases. Consequently, use of CA 15-3 and TAG 72 in combination with CA 125 can increase the apparent specificity of the CA 125 assay for distinguishing malignant from benign disease. Prospective studies will be required to test critically whether the use of additional serum markers in combination with the CA 125 assay would contribute to the specificity of a cost-effective screening strategy for ovarian cancer.
A method for implementing fractal image compression on reconfigurable architecture (1999)

No abstract available.
Reclamation of Acetone in Plastination Laboratories: A Simple and Inexpensive Method (1997)

Since the introduction of the plastination process by von Hagens [Anat Rec 194/2: 247-256, 1979], the cost of acetone used for the dehydration step has been considered an important factor in the cost of plastination. We have developed a three-step method that permits the reuse of acetone. The first step simply consists of storing the contaminated acetone in the freezer and separating the congealed fat by filtration. The second step is vacuum distillation of the acetone and can be conducted with the freezer and vacuum pump (found in any plastination laboratory) with just a few additions. It produces 95-97% pure acetone. The last step uses a desiccant to take away the residual water from the distilled acetone and brings the purity to 99.5%. With this method, we have reduced the amount of acetone to be purchased to a minimum and completely eliminated the cost of discarding used acetone. In addition vaporized acetone released during the impregnation step of plastination is recaptured.
Nuclear magnetic resonance investigation of alkylcobaloxime dimers (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear magnetic resonance investigation of alkylcobaloxime dimersAlbert W. Herlinger and Theodore L. BrownCite this: J. Am. Chem. Soc. 1972, 94, 2, 388–393Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/ja00757a014https://doi.org/10.1021/ja00757a014research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cystic Fibrosis Database (CFDB): A new web‐based tool for cystic fibrosis specialists (2014)

In order to help specialists involved in CF care and clinical research to know the current best evidence about clinical effectiveness of interventions in CF, we designed and developed a web-based, free access tool called "CFDB"--Cystic Fibrosis DataBase (www.inetflow.it/CFDB). The database was built by searching in Medline, Embase, Cochrane Library and worldwide trials registries all studies involving clinical interventions in CF. The tool lets the user define queries starting from one or more types of pathological conditions and one or more interventions. The output of the queries is structured in three levels: (1) how many and which studies deal with the conditions formulated in the query; (2) which are the main results of these studies; (3) a critical summary of the literature related to the query. This tool, providing a quick overview of the available evidence in clinical research in CF, may help clinical decision making, designing of new trials and building guidelines.
L'ENGAGEMENT CONTRE LA PAUVRET E EN BOLIVIE (2004)

Este trabajo muestra la conjunción de políticas macroeconómicas y políticas de desarrollo endógeno: la degradación económica, la realidad de la pobreza y el papel de las políticas endógenas. Bolivia es un ejemplo de este tipo de conjunción de ambas.
Long-Period Gratings in Highly Germanium-Doped, Single-Mode Optical Fibers for Sensing Applications (2018)

Long-period fiber gratings (LPGs) are well known for their sensitivity to external influences, which make them interesting for a large number of sensing applications. For these applications, fibers with a high numerical aperture (i.e., fibers with highly germanium (Ge)-doped fused silica fiber cores) are more attractive since they are intrinsically photosensitive, as well as less sensitive to bend- and microbend-induced light attenuations. In this work, we introduce a novel method to inscribe LPGs into highly Ge-doped, single-mode fibers. By tapering the optical fiber, and thus, tailoring the effective indices of the core and cladding modes, for the first time, an LPG was inscribed into such fibers using the amplitude mask technique and a KrF excimer laser. Based on this novel method, sensitive LPG-based fiber optic sensors only a few millimeters in length can be incorporated in bend-insensitive fibers for use in various monitoring applications. Moreover, by applying the described inscription method, the LPG spectrum can be influenced and tailored according to the specific demands of a particular application.
18F-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: approaches to synthesis and development prospects (2017)

The pathogenesis of many socially significant diseases such as neurodegenerative dementias and neuroendocrine tumours involves imbalance of neurotransmitters. Among the known neuroimaging methods, positron emission tomography (PET) is the most perfect and informative technique for diagnosing these diseases. The potential of PET is largely determined by the inventory of available radiopharmaceuticals, that is, biologically active molecules containing short-lived nuclides with positron decay. This review gives a systematic account of the application of fluorine-18-labelled catecholamine type radiopharmaceuticals in clinical investigations of the sympathetic and central nervous systems. The methods for the synthesis of these agents and existing problems are considered. The material is arranged according to the mechanisms of reactions that underlie the synthetic approaches: electrophilic, nucleophilic and metal-catalyzed reactions. The bibliography includes 198 references.
Refined effective-medium model for the optical properties of nanoparticles coated with anisotropic molecules (2021)

This work aims to provide a simple yet complete effective dielectric function for an anisotropic layer of polarizable molecules adsorbed on a metallic surface. This effective medium model considers the important and nontrivial case of nonvacuum embedding media and accounts for orientation effects, coverage dependence through dipole-dipole interactions, and image-dipole effects. To check the model's validity, we focus in particular on the experimentally relevant case of dyes adsorbed on metallic nanospheres. We can then use anisotropic Mie theory, together with the effective dielectric function describing the molecular coating, to calculate their optical properties. We show that this effective medium description is in very good agreement with more elaborate and computationally intensive microscopic calculations based on coupled-dipole models. The effective medium model therefore provides a simple means to investigate orientation effects and coverage dependence, including in more complex systems such as dyes adsorbed on nonspherical or ensembles of nanoparticles. This model can readily be used to further our theoretical understanding of dye-nanoparticle systems, for example in the context of dye-plasmon resonance coupling or surface-enhanced Raman and fluorescence spectroscopy.
MetaCarta at GeoCLEF 2005 (2005)

In this paper we divide the processing steps required for the GeoCLEF task into two parts: those that are likely common to all participants and those that are specific to the MetaCarta system.After analyzing the 2005 task we conclude that it has surprisingly little geographic content.
Four New Mutations in the Erythroid-Specific 5-Aminolevulinate Synthase (ALAS2) Gene Causing X-Linked Sideroblastic Anemia: Increased Pyridoxine Responsiveness After Removal of Iron Overload by Phlebotomy and Coinheritance of Hereditary Hemochromatosis (1999)

X-linked sideroblastic anemia (XLSA) in four unrelated male probands was caused by missense mutations in the erythroid-specific 5-aminolevulinate synthase gene (ALAS2). All were new mutations: T647C, C1283T, G1395A, and C1406T predicting amino acid substitutions Y199H, R411C, R448Q, and R452C. All probands were clinically pyridoxine-responsive. The mutation Y199H was shown to be the first de novo XLSA mutation and occurred in a gamete of the proband’s maternal grandfather. There was a significantly higher frequency of coinheritance of the hereditary hemochromatosis (HH)HFE mutant allele C282Y in 18 unrelated XLSA hemizygotes than found in the normal population, indicating a role for coinheritance ofHFE alleles in the expression of this disorder. One proband (Y199H) with severe and early iron loading coinherited HH as a C282Y homozygote. The clinical and hematologic histories of two XLSA probands suggest that iron overload suppresses pyridoxine responsiveness. Notably, reversal of the iron overload in the Y199H proband by phlebotomy resulted in higher hemoglobin concentrations during pyridoxine supplementation. The proband with the R452C mutation was symptom-free on occasional phlebotomy and daily pyridoxine. These studies indicate the value of combined phlebotomy and pyridoxine supplementation in the management of XLSA probands in order to prevent a downward spiral of iron toxicity and refractory anemia.
Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells (1997)

An important step in the pathogenesis of Neisseria meningitidis is the crossing of two cellular barriers, one in the nasopharynx and one in the brain. To approach the mechanisms by which this bacterium can achieve these goals, we studied the interactions between N. meningitidis and a monolayer of polarized tight junction-forming T84 cells grown on filter units. A capsulated, piliated, Opa-, and Opc- N. meningitidis strain is shown to be capable of adhering to and crossing this monolayer several orders of magnitude more efficiently than an isogenic nonpiliated derivative. This bacterial interaction does not affect the barrier function of tight junctions, as assessed by (i) the absence of modification of the transepithelial resistance, (ii) the lack of increase of [3H]inulin penetration across the monolayer, and (iii) the absence of delocalization of ZO-1, a tight junction protein. Electron microscopy studies and confocal examinations demonstrated that N. meningitidis (i) induces cytoskeletal rearrangements with actin polymerization beneath adherent bacteria, (ii) is intimately attached to the apical membrane of the cells, and (iii) can be internalized inside cells. Immunofluorescent staining with antipilus antibodies showed evidence that meningococcal piliation was dramatically reduced at later time points of bacterial cell interaction compared to the early phase of this interaction. In addition, adhesive bacteria recovered from an infected monolayer are piliated, capsulated, Opa-, and Opc-, a phenotype similar to that of the parental strain. Taken together, these data demonstrate that following pilus-mediated adhesion, N. meningitidis is involved in an intimate attachment which requires a bacterial component different from Opa and Opc and that meningococci cross a monolayer of tight-junction-forming epithelial cells by using a transcellular pathway rather than a paracellular route.