gebhart/patrepeval huggingface dataset:
Graphene for antenna applications: Opportunities and challenges from microwaves to THz (2012)

The use of graphene for antennas and other electromagnetic passives could bring significant benefit such as extreme miniaturization, monolithic integration with graphene RF nanoelectronics, efficient dynamic tuning, and even transparency and mechanical flexibility. Though recently different related theoretical works have been presented, relatively few applications have been proposed and realistically assessed. In this invited talk we will briefly review the main properties of graphene and the state of the art in its theoretical and experimental characterization. Then, we will discuss a number of potential antenna applications from microwave to THz, providing in each case a critical assessment of the benefits, limitations, and remaining issues towards actual real-life implementations. Here we provide a brief overview of different devices and associated developments in our group discussed in the talk, including graphene antennas and reflectarrays at microwave and THz, plasmonic switches, isotropic and anisotropic meta-surfaces, or graphene RF-NEMS.
Multiple target response of data-processing antennas (1962)

The response of nonlinear data-processing antenna arrays are evaluated for multiple target situations. These situations involve targets of various relative strengths and angular separations. The evaluation is carried out both analytically and graphically, and the results obtained are compared to the performance of a linear array.
Microwave-Assisted Extraction Applied to Merlot Grapes with Contrasting Maturity Levels: Effects on Phenolic Chemistry and Wine Color (2019)

Merlot grapes were harvested with three maturity levels (21.1, 23.1, and 25.1 Brix), and processed with or without the application of microwave-assisted extraction (MW). The detailed phenolic composition and color were followed during winemaking. The MW treatment did not affect the basic chemical composition of the wines. Upon crushing, MW caused a 211% improvement in anthocyanins in the wines of the first harvest and an 89% improvement in the wines of the third harvest. At bottling, MW favored the formation of pyranoanthocyanins and tannin-anthocyanin dimers. Tannin extraction was not affected by MW just after application of this process, but improvements of 30, 20, and 10% on MW-treated wines of the first, second, and third harvest, respectively, were recorded at pressing. The formation of polymeric pigments during aging generally increased along with harvest date and was only favored in MW-treated wines of the first and third harvest, with preferential formation of small polymeric pigments, in accordance with enhanced anthocyanin extraction in these wines. Initial improvements of wine color upon application of MW in the wines of the first, second, and third harvest were of 275, 300, and 175%, respectively. Although these differences subsided or disappeared for the wines of the second and third harvest during aging, the wines of the first harvest treated with MW retained 52% more color than Control wines at day 150 post-crushing. Results suggest the MW treatment was more efficient in extracting and retaining phenolics and color when applied to unripe fruit.
Twin boundary migration in an individual platinum nanocrystal during catalytic CO oxidation (2021)

At the nanoscale, elastic strain and crystal defects largely influence the properties and functionalities of materials. The ability to predict the structural evolution of catalytic nanocrystals during the reaction is of primary importance for catalyst design. However, to date, imaging and characterising the structure of defects inside a nanocrystal in three-dimensions and in situ during reaction has remained a challenge. We report here an unusual twin boundary migration process in a single platinum nanoparticle during CO oxidation using Bragg coherent diffraction imaging as the characterisation tool. Density functional theory calculations show that twin migration can be correlated with the relative change in the interfacial energies of the free surfaces exposed to CO. The x-ray technique also reveals particle reshaping during the reaction. In situ and non-invasive structural characterisation of defects during reaction opens new avenues for understanding defect behaviour in confined crystals and paves the way for strain and defect engineering.
Energy levels, charge injection, charge recombination and dye regeneration dynamics for donor–acceptor π-conjugated organic dyes in mesoscopic TiO2 sensitized solar cells (2011)

Two new D–π–A type organic sensitizers, MP124 and MP-I-50, were synthesized and their electrochemical and spectroscopic properties studied. Efficiencies of DSSC devices utilizing these dyes were also investigated, where sensitization solvent, sensitization time and additive concentration were all varied. Under standard AM 1.5G simulated solar radiation, optimized MP124 devices show an efficiency of 7.45% (Voc = 0.73 V; Jsc = 14.44 mA cm−2; FF = 70%) while optimized MP-I-50 devices show an efficiency of 5.66% (Voc = 0.68 V; Jsc = 12.06 mA cm−2; FF = 69%). Transient absorption spectroscopy studies show that regeneration of dye cations by the red-ox electrolyte was more efficient in MP124cells which is attributed to its higher HOMO energy leading to greater driving force for the regeneration reaction. Transient photovoltage studies showed that electron lifetimes were longer lived in MP124 explaining the higher Voc for these cells compared to MP-I-50cells. DFT and MP2 calculations indicate that this is due to the greater tendency of MP-I-50 to form charge-transfer complexes with the I2 species in the electrolyte, due to the presence of an additional EDOT in its structure compared to MP124. This work highlights the effect that small changes to the sensitizer structure can have on the interfacial charge transfer reactions and ultimately on the device efficiency.
Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence (2009)

Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosome binding regions. N-terminal LANA binds histones H2A/H2B to attach to chromosomes, and this binding is essential for episome persistence. We now investigate the role of C-terminal chromosome binding in LANA function. Alanine substitutions for LANA residues (1068)LKK(1070) and (1125)SHP(1127) severely impaired chromosome binding but did not reduce the other C-terminal LANA functions of self-association or DNA binding. The (1068)LKK(1070) and (1125)SHP(1127) substitutions did not reduce LANA's inhibition of RB1-induced growth arrest, transactivation of the CDK2 promoter, or C-terminal LANA's inhibition of p53 activation of the BAX promoter. When N-terminal LANA was wild type, the (1068)LKK(1070) and (1125)SHP(1127) substitutions also did not reduce LANA chromosome association or episome persistence. However, when N-terminal LANA binding to chromosomes was modestly diminished, the substitutions in (1068)LKK(1070) and (1125)SHP(1127) dramatically reduced both LANA chromosome association and episome persistence. These data suggest a model in which N- and C-terminal LANA cooperatively associates with chromosomes to mediate full-length LANA chromosome binding and viral persistence.
Autoimmune Diabetes and the Circle of Tolerance (2004)

The concept of immunological tolerance is central to our understanding of type 1 diabetes and the development of strategies for its prediction, prevention, and cure. Tolerance simply refers to the absence of an immune response. Most of us are born with an immune system that develops tolerance to all the other systems of our bodies as well as to the things that we eat. It is the loss of immunological tolerance that leads to autoimmunity. And when that autoimmune response directly or indirectly targets the beta-cell, type 1 diabetes is the result. In the U.S., 1 in 600 of us loses tolerance to pancreatic beta-cells. Interference with T-cell function after the loss of tolerance, as can be achieved with immunosuppressive drugs like cyclosporin, arrests the disease, but the cost in side effects is high. Clearly, stopping the loss of tolerance would be preferable. If we can stop the loss of tolerance, we can prevent the disease. We and many others have investigated both approaches. But what of the people who already have diabetes? For them a separate but related strategy, tolerance induction, is required. Specifically, islet transplantation tolerance induction holds out the promise of being able to cure the disease. This has been the ultimate goal of our laboratory's work for the past two decades.
Cancer in sub-Saharan Africa (2020)

Knowledge of cancer in Africa brings needed diversity to improve health worldwide
Technical Note: Hot Corrosion Resistance of Nano-Structured Sol-Gel Alumina-Coated 9Cr-1Mo Ferritic Steel in Air/Salt Environments (2013)

Synthesized boehmite (AlO[OH]) sol was deposited on 9Cr-1Mo ferritic steel substrates using a dip coating technique. The coated substrates were heat-treated at 300°C to obtain a precursor-free alumina coating. Atomic force microscopy (AFM) analysis of the coated surfaces confirmed the presence of nano-sized alumina particles (8 nm to 12 nm) in the coating. The alumina-coated and uncoated samples were subjected to a hot corrosion test in lithium chloride-sodium chloride (LiCl-NaCl) and sodium sulfate-potassium sulfate (Na2SO4-K2SO4) salt mixtures separately at 650°C and 850°C, respectively. Oxidation kinetics study has indicated a significant improvement in the hot corrosion resistances of the coated substrates. Microstructural examinations of the oxidized substrates have revealed the presence of comparatively compact and less porous oxide scale at the coated specimens, whereas relatively very thick scale filled with cracks and voids were noticed on the uncoated oxidized specimens.
Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria (2017)

Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime-avibactam and meropenem-vaborbactam have provided two novel therapeutic options for the treatment of multidrug-resistant infections caused by Gram-negative bacteria. Most importantly, these combination agents have satisfied an important medical need related to antibiotic-resistant Klebsiella pneumoniae that produce serine carbapenemases, especially the Klebsiella pneumoniae carbapenemase (KPC) enzymes. Both combinations contain non-β-lactam β-lactamase inhibitors of novel chemical classes not previously developed as antibacterial agents, the diazabicyclooctanes and cyclic boronic acid derivatives. Their rapid development and approval programs have spurred a number of similar inhibitor combinations that will need to differentiate themselves for commercial success. Gaps still exist for the treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa, Acinetobacter spp., and metallo-β-lactamase-producing pathogens. Overall, the new β-lactamase inhibitor combinations have infused new life into the search for new antibacterial agents to treat multidrug-resistant bacteria.
ChemInform Abstract: FOUR LAYER COMPLEXES. PART 2. NEW COURSE FOR TRINUCLEAR COMPLEXES ‐ STRUCTURE E OF THE FOUR LAYER SANDWICH COMPLEXES BIS(η‐THIADIBOROLENE‐COBALT‐μ,η‐THIADIBOROLENE) IRON (1980)

Abstract Struktur des Tetradecker‐Sandwichkomplexes Bis(n‐thiadiborolencobalt‐p,n‐thiadioborolen)eisen.
Where can I drive? A System Approach: Deep Ego Corridor Estimation for Robust Automated Driving (2021)

Lane detection is an essential part of the perception sub-architecture of any automated driving (AD) or advanced driver assistance system (ADAS). When focusing on low-cost, large scale products for automated driving, model-driven approaches for the detection of lane markings have proven good performance. More recently, data-driven approaches have been proposed that target the drivable area / freespace mainly in inner-city applications. Focus of these approaches is less on lane-based driving due to the fact that the lane concept does not fully apply in unstructured, residential inner-city environments. So-far the concept of drivable area is seldom used for highway and inter-urban applications due to the specific requirements of these scenarios that require clear lane associations of all traffic participants. We believe that lane-based, mapless driving in inter-urban and highway scenarios is still not fully handled with sufficient robustness and availability. Especially for challenging weather situations such as heavy rain, fog, low-standing sun, darkness or reflections in puddles, the mapless detection of lane markings decreases significantly or completely fails. We see potential in applying specifically designed data-driven freespace approaches in more lane-based driving applications for highways and inter-urban use. Therefore, we propose to classify specifically a drivable corridor of the ego lane on pixel level with a deep learning approach. Our approach is kept computationally efficient with only 0.66 million parameters allowing its application in large scale products. Thus, we were able to easily integrate into an online AD system of a test vehicle. We demonstrate the performance of our approach under challenging conditions qualitatively and quantitatively in comparison to a state-of-the-art model-driven approach. We see the current approach as part of a fallback path whenever model-driven approaches cannot cope with a challenging scenario. We give insights how such a fallback path can be integrated into an AD system, thereby extending the overall system availability.
Least action principles for incompressible flows and optimal transport between shapes (2016)

As V. I. Arnold observed in the 1960s, the Euler equations of incompressible fluid flow correspond formally to geodesic equations in a group of volume-preserving diffeomorphisms. Working in an Eulerian framework, we study incompressible flows of shapes as critical paths for action (kinetic energy) along transport paths constrained to be shape densities (characteristic functions). The formal geodesic equations for this problem are Euler equations for incompressible, inviscid potential flow of fluid with zero pressure and surface tension on the free boundary. The problem of minimizing this action exhibits an instability associated with microdroplet formation, with the following outcomes: Any two shapes of equal volume can be approximately connected by an Euler spray---a countable superposition of ellipsoidal geodesics. The infimum of the action is the Wasserstein distance squared, and is almost never attained except in dimension 1. Every Wasserstein geodesic between bounded densities of compact support provides a solution of the (compressible) pressureless Euler system that is a weak limit of (incompressible) Euler sprays. Each such Wasserstein geodesic is also the unique minimizer of a relaxed least-action principle for a two-fluid mixture theory corresponding to incompressible fluid mixed with vacuum.
Follistatin-like 1 Prevents Renal Ischemia-Reperfusion Injury by Inhibition of Apoptosis via Upregulating AMPK/PPAR-δ Pathway (2023)

Abstract Follistatin-like 1 (FSTL-1), a secreted glycoprotein, is upregulated in the serum of patients with acute kidney injury. However, it is unknown whether it protects against renal ischemia-reperfusion (I/R) injury. Our present study found that treatment with FSTL-1 (100 mg/kg) intravenous injection alleviated renal injury, as evidenced by reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels, along with reduced histopathological kidney damage. Moreover, FSTL-1 treatment reduced the number of apoptotic cells and the accumulation of reactive oxygen species (ROS) during I/R injury. The protective effect of FSTL-1 was via AMPK/PPAR-δ pathway, because, after blockade of AMPK/PPAR-δ pathway by individual inhibitor (GSK0660, a PPAR-δ antagonist, or compound C, an AMPK inhibitor), the protective effects of FSTL-1 on oxidative stress and apoptosis were blocked. Taken together, our results reveal that FSTL-1 attenuates renal I/R injury by inhibiting apoptosis in renal tubular epithelial cells, which is meditated by activating AMPK/PPAR-δ pathway.
High-Precision Dual-Stage Pointing Mechanism for Miniature Satellite Laser Communication Terminals (2020)

This article presents an innovative mechatronic design of a high-accuracy pointing mechanism for orbital laser communication terminals. The system is based on a dual-stage architecture and is miniaturized to fit nanosatellite-class spacecraft, aiming to enable optical communication on small-size space platforms. The focus is on control design aspects and on the performance assessment of an experimental prototype under emulated external environmental disturbances.
Targeting AREG derived from senescent stromal cells diminishes cancer resistance and averts PD-L1-mediated immunosuppression (2019)

Agingis characterized by a progressive loss of physiological integrity, while cancer represents one of the primarypathologicalfactorsthat severely threatenhuman lifespan and healthspan.In clinical oncology, drug resistance limits the efficacy of most anticancer treatments, andidentification of major mechanisms remains a key to solve thischallenging issue. Here we highlight the multifaceted senescence-associated secretory phenotype (SASP), which comprises numerous soluble factors including amphiregulin (AREG). Production of AREG is triggered by DNA damage to stromal cells which passively enter senescence in the tumor microenvironment (TME), aprocess that remarkably enhances cancer malignancy including acquired resistance mediated by EGFR. Furthermore, Paracrine AREG induces PD-L1 expression in recipient cancer cells and createsan immunosuppressive TME via immune checkpoint activation against cytotoxic lymphocytes. Targeting AREG not only minimizedchemoresistanceof cancer cells, but also restored immunocompetency when combined with classical chemotherapy in humanized animals. Our study underscores the potential of in vivoSASP in driving the TME-mediated drug resistance and shaping an immunosuppressive niche, and provides the proof-of-principle of targeting major SASP factors to improve therapeutic outcome in cancer medicine, the success of which can substantially reduce aging-related morbidity and mortality.
Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells (2001)

Bone marrow is the primary site of metastasis in patients with advanced stage prostate cancer. Prostate carcinoma cells metastasizing to bone must initially adhere to endothelial cells in the bone marrow sinusoids. In this report, we have modeled that interaction in vitro using two bone marrow endothelial cell (BMEC) lines and four prostate adenocarcinoma cell lines to investigate the adhesion mechanism. Highly metastatic PC3 and PC3M-LN4 cells were found to adhere rapidly and specifically (70-90%) to BMEC-1 and trHBMEC bone marrow endothelial cells, but not to human umbilical vein endothelial cells (15-25%). Specific adhesion to BMEC-1 and trHBMEC was dependent upon the presence of a hyaluronan (HA) pericellular matrix assembled on the prostate carcinoma cells. DU145 and LNCaP cells were only weakly adherent and retained no cell surface HA. Maximal BMEC adhesion and HA encapsulation were associated with high levels of HA synthesis by the prostate carcinoma cells. Up-regulation of HA synthase isoforms Has2 and Has3 relative to levels expressed by normal prostate corresponded to elevated HA synthesis and avid BMEC adhesion. These results support a model in which tumor cells with up-regulated HA synthase expression assemble a cell surface hyaluronan matrix that promotes adhesion to bone marrow endothelial cells. This interaction could contribute to preferential bone metastasis by prostate carcinoma cells.
Power Plant Classification from Remote Imaging with Deep Learning (2021)

Satellite remote imaging enables the detailed study of land use patterns on a global scale. We investigate the possibility to improve the information content of traditional land use classification by identifying the nature of industrial sites from medium-resolution remote sensing images. In this work, we focus on classifying different types of power plants from Sentinel-2 imaging data. Using a ResNet-50 deep learning model, we are able to achieve a mean accuracy of 90.0% in distinguishing 10 different power plant types and a background class. Furthermore, we are able to identify the cooling mechanisms utilized in thermal power plants with a mean accuracy of 87.5%. Our results enable us to qualitatively investigate the energy mix from Sentinel-2 imaging data, and prove the feasibility to classify industrial sites on a global scale from freely available satellite imagery.
An evolutionary treasure: unification of a broad set of amidohydrolases related to urease (1997)

The recent determination of the three-dimensional structure of urease revealed striking similarities of enzyme architecture to adenosine deaminase and phosphotriesterase, evidence of a distant evolutionary relationship that had gone undetected by one-dimensional sequence comparisons. Here, based on an analysis of conservation patterns in three dimensions, we report the discovery of the same active-site architecture in an even larger set of enzymes involved primarily in nucleotide metabolism. As a consequence, we predict the three-dimensional fold and details of the active site architecture for dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases, and proteins involved in animal neuronal development. Two member families are common to archaea, eubacteria, and eukaryota. Thirteen other functions supported by the same structural motif and conserved chemical mechanism apparently represent later adaptations for different substrate specificities in different cellular contexts. © 1997 Wiley-Liss Inc.