gebhart/patrepeval huggingface dataset:
Bioinspired design and assembly of platelet reinforced polymer films with enhanced absorption properties (2014)

The brick–mortar structure CuS/PVDF nanocomposite films with enhanced absorption properties were fabricated based on the selectively synthesized CuS hexagonal nanoplatelets and PVDF.
Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins (2016)

Sirtuins are NAD(+)-dependent lysine deacylases, regulating a variety of cellular processes. The nuclear Sirt1, the cytosolic Sirt2, and the mitochondrial Sirt3 are robust deacetylases, whereas the other sirtuins have preferences for longer acyl chains. Most previous studies investigated sirtuin-catalyzed deacylation on peptide substrates only. We used the genetic code expansion concept to produce natively folded, site-specific, and lysine-acetylated Sirt1-3 substrate proteins, namely Ras-related nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation reaction. Some acetylated proteins such as Ras-related nuclear, p53, and Hsp10 were robustly deacetylated by Sirt1-3. However, other reported sirtuin substrate proteins such as cyclophilin D, superoxide dismutase, and PEPCK1 were not deacetylated. Using a structural and functional approach, we describe the ability of Sirt1-3 to deacetylate two adjacent acetylated lysine residues. The dynamics of this process have implications for the lifetime of acetyl modifications on di-lysine acetylation sites and thus constitute a new mechanism for the regulation of proteins by acetylation. Our studies support that, besides the primary sequence context, the protein structure is a major determinant of sirtuin substrate specificity.
[Combination Therapy of Hepatic Arterial Infusion Chemotherapy and Surgical Resection against Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis]. (2019)

We have performed a combination therapy of hepatic arterial infusion chemotherapy(HAIC), radiation therapy(RT), and surgical resection for the treatment of hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT)since 2013. We retrospectively analyzed 36 patients with HCC with PVTT who underwent hepatectomy between 1995 and 2016 to evaluate the clinical outcomes. Ten patients received preoperative HAIC, 7 underwent RT, and 14 received postoperative HAIC. The median survival time(MST)was 19.3 months, and the MST was significantly longer in the patients who underwent curative resection than those in patients who did not. In the non-curative resection group, postoperative HAIC prolonged the survival.
Dynamics of Water Droplet Distortion and Breakup in a Uniform Electric Field (2011)

Distortion of a free droplet in a uniform electric field is studied numerically using the boundary element method. It is assumed that the droplet is made of an ideally conducting liquid. There exists a critical magnitude of the electric field intensity. The droplet oscillates for weaker electric fields and elongates until a thin jet emanating from the droplet tip is formed for stronger electric fields. Numerical predictions agree reasonably well with the available experimental data.
On MIMO phase noise channels at high SNR (2016)

We consider the point-to-point multi-input-multiple-output (MIMO) channel with phase uncertainty (MIMO phase noise channel) at high SNR. With phase noise on the individual paths of the channel (model A), we show that the multiplexing gain is 1/2, which implies that the capacity does not scale with the channel dimension at high SNR. With phase noise at both the input and output of the channel (model B), the multiplexing gain is upper-bounded by 1/2 min{n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> , (n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> - 2) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> + 1}, and lower-bounded by 1/2 min{n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> , ⌊n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> +1/2⌋}, where n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> and n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> are the number of transmit and receive antennas, respectively. The multiplexing gain is enhanced to 1/2 min{n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> , n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> } without receive phase noise, and to 1/2 min{2n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> - 1, n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> } without transmit phase noise. Our main results rely on the derivation of non-trivial upper and lower bounds on the capacity of such channels.
Prolamine‐Based Matrices for Biomedical Applications (2015)

This chapter contains sections titled: Introduction Gliadin – Prolamine Isolated from Wheat Gluten Zein - Prolamine Isolated from Corn Gluten Meal Soy Protein – Prolamine Isolated from Soybean Kafirin – Prolamine Isolated from Sorghum Conclusion and Future Perspective
Formation of soluble complexes of cationic polypyridylphenylene dendrimers with DNA (2010)

The complexation of DNA with a dendrimer with the successive addition of the dendrimer solution to the solution of DNA leads to the appearance and accumulation of compact particles with a diameter of D h = 100 ± 10 nm that coexist with particles whose dimensions coincide with those of free DNA molecules (D h = 450 ± 50 nm). The fraction of large particles decreases regularly; moreover, when the equimolar ratio of charged groups of interacting components is achieved, these particles disappear. The coexistence of practically free DNA molecules and a compact soluble negatively charged complex is confirmed by a sedimentation assay. Further addition of the dendrimer up to a certain ratio of charged groups of the components, much higher than unity, brings about phase separation, while at a large excess of charge groups of the dendrimer (above fivefold), the system turns out to be fully single-phase and composed of compact (110 ± 10 nm) cationic soluble complexes. Owing to the positive charge and small size of complex particles no greater than a critical value of 150 nm, the particles possess an important ability to interact with a positively charged cell membrane and to enter a living cell via endocytosis.
State‐dependent life history models in a changing (and regulated) environment: steelhead in the California Central Valley (2009)

We use a state dependent life history model to predict the life history strategies of female steelhead trout (Oncorhynchus mykiss) in altered environments. As a case study of a broadly applicable approach, we applied this model to the American and Mokelumne Rivers in central California, where steelhead are listed as threatened. Both rivers have been drastically altered, with highly regulated flows and translocations that may have diluted local adaptation. Nevertheless, evolutionary optimization models could successfully predict the life history displayed by fish on the American River (all anadromous, with young smolts) and on the Mokelumne River (a mix of anadromy and residency). The similar fitness of the two strategies for the Mokelumne suggested that a mixed strategy could be favored in a variable environment. We advance the management utility of this framework by explicitly modeling growth as a function of environmental conditions and using sensitivity analyses to predict likely evolutionary endpoints under changed environments. We conclude that the greatest management concern with respect to preserving anadromy is reduced survival of emigrating smolts, although large changes in freshwater survival or growth rates are potentially also important. We also demonstrate the importance of considering asymptotic size along with maximum growth rate.
Activation domains for controlling plant gene expression using designed transcription factors (2013)

Targeted gene regulation via designed transcription factors has great potential for precise phenotypic modification and acceleration of novel crop trait development. To this end, designed transcriptional activators have been constructed by fusing transcriptional activation domains to DNA-binding proteins. In this study, a transcriptional activator from the herpes simplex virus, VP16, was used to identify plant regulatory proteins. Transcriptional activation domains were identified from each protein and fused with zinc finger DNA-binding proteins (ZFPs) to generate designed transcriptional activators. In addition, specific sequences within each transcriptional activation domain were modified to mimic the VP16 contact motif that interacts directly with RNA polymerase II core transcription factors. To evaluate these designed transcriptional activators, test systems were built in yeast and tobacco comprising reporter genes driven by promoters containing ZFP-binding sites upstream of the transcriptional start site. In yeast, transcriptional domains from the plant proteins ERF2 and PTI4 activated MEL1 reporter gene expression to levels similar to VP16 and the modified sequences displayed even greater levels of activation. Following stable transformation of the tobacco reporter system with transcriptional activators derived from ERF2, GUS reporter gene transcript accumulation was equal to or greater than those derived from VP16. Moreover, a modified ERF2 domain displayed significantly enhanced transcriptional activation compared with VP16 and with the unmodified ERF2 sequence. These results demonstrate that plant sequences capable of facilitating transcriptional activation can be found and, when fused to DNA-binding proteins, can enhance gene expression.
235. Improved Ex Vivo Gene Therapy Using Highly Purified Hematopoietic Stem and Progenitor Cells (2016)

Ex vivo gene addition into CD34+ hematopoietic stem and progenitor cells (HSPC) followed by autologous transplantation has proven a safe and efficacious therapy for immunodeficiencies, storage diseases and hemoglobinopathies. According to xenograft models and population size estimates of vector-marked cells in gene therapy-treated patients, less than 0.01% of infused CD34+ cells drive long-term (LT) repopulation. Advances in clinical-grade cell sorting technology may make HSC-enriched CD34+ subpopulations accessible for gene therapy, with advantages in terms of lentiviral vector (LV) cost, safety (lowering of integration load) and, potentially, efficacy. By differentially marking mobilized peripheral blood (mPB) CD34 subpopulations distinguished by increasing levels of CD38 expression in order to quantitatively assess their hematopoietic output in an NSG xenograft model over 6 months, we previously mapped most (>90%) LT repopulating capacity to CD34+CD38- cells (lowest 10% CD38 staining), while CD34+CD38int cells drove short-term (ST) reconstitution during the first 2 months after transplantation. We now characterize these subpopulations in terms of CD90 expression, a marker, which has been used in conjunction with CD34 for HSC purification in past clinical trials. CD34+ mPB cells were sorted into CD38-90+ (5% of CD34+), CD38-90- (5%), CD38+90+ (30%) and CD38+90- (60%) fractions and exhaustively transduced with GFP-, OFP-, BFP- and mCherry-expressing LVs, respectively. Differentially marked subfractions were pooled maintaining their original proportions and transplanted into NSG mice. ST engraftment mainly came from CD38+ cells, with equal contribution from the CD90+ and CD90- compartment. LT engraftment was almost exclusively derived from CD34+CD38- cells, of which 70% came from CD90+ and 30% from CD90- cells. Hence, CD34+CD38- is a more sensitive and specific marker combination than CD34+CD90+ to purify LT-HSC. CD34+CD38- cells can be purified by a sequential bead-based selection (CD34 selection of CD38-depleted cells) potentially applicable to clinical practice. We show that CD34+CD38- cells can be efficiently transduced with clinical grade LVs using shortened ex vivo manipulation protocols, reaching similar gene marking levels as with the standard protocol currently used in clinical trials that comprises a double dose of LV. Transduction was stable for at least 5 months when serially measured in xenotransplanted mice, and mice showed multi-lineage hematopoiesis indistinguishable from CD34+ grafts. Based on these results, we are aiming towards clinical development of a new gene therapy protocol based on CD34+CD38-HSPC efficiently transduced with minimum ex vivo culture time (<36h). Our platform will substantially improve the efficacy, safety and feasibility of future ex vivo gene therapy studies.
Supplementary Table S6 from Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup (2023)

&lt;p&gt;Supplementary Table S6&lt;/p&gt;
Contribución de los canales SK a la electrofisiología ventricular humana en pacientes con insuficiencia cardíaca (2021)

En este estudio se ha probado la presencia y funcionalidad de los canales SK en láminas de tejido ventricular provenientes de pacientes con insuficiencia cardíaca. Para ello se han utilizado técnicas de mapeo óptico y se han activado selectivamente los canales con el activador SKA-31.
CO<inf>2</inf> adsorption process simulation in ASPEN Hysys (2017)

The main objective of the paper consists to analyze the adsorption process for capturing the carbon dioxide generated from the fossil fuel power plants. For simplifying our analysis, we have considered that the stream contains only carbon dioxide and nitrogen in a mole concentration of 13/87 %. The adsorption process was simulated in the Aspen Adsorption V9 considering silica gel impregnated with amine and activated carbon. In this case, an adsorption column of 10 cm length was used according to the exhaust gases flow in order to achieve a CO2 capture efficiency of 85 %. However, the CO2 capture efficiency of 85 % was obtained only for silica gel due to its chemical properties. In the activated carbon case, the CO2 capture efficiency was 77 %. In both cases, the maximal efficiency was obtained after 10 s due to the adsorption capacity of the bed.
Synthesis of Bridgehead Nitrogen Heterocycles via Cyclization of α-Ammonio 5-Hexenyl Radicals (1999)

Ring-closure of the 2,2-dimethyl-2-azonia-5-hexenyl radical (4) proceeds smoothly and efficiently to give the 5-exo isomer essentially quantitatively, in accordance with predictions based on MP4SDTQ/6-31G ab initio calculations on the thermodynamic stability of alpha-ammonio radicals. The corresponding 5-hexynyl radical species 15 and its 6-phenyl derivative 19 display similar behavior affording the analogous 5-exo-3-methylenepyrrolidinium salts in high yield. In none of these cases were the products of reduction were detected. All of the radical intermediates were generated conveniently by treatment of the iodomethyl and/or phenylselenomethyl salts with tributyltin hydride. Application of this procedure to monocyclic precursors such as 1-methyl-1-iodomethyl-4-methylene-1-azoniacyclohexyl iodide (31) provided an attractive entry into quaternary derivatives of the 1-azabicyclo[2.2.1]heptyl system in good yield via a three-step sequence from 1-methylpiperidone. Dequaternization of the bicyclic salts so obtained unexpectedly leads to rupture of one of the rings rather than loss of the N-methyl group. The 1-azabicyclo[2.2.1]heptane could be accessed readily via tin hydride-induced cyclization of the corresponding N-phenylethylammonium salt 54, followed by Hofmann elimination with potassium tert-butoxide.
Hot coupling: a particle approach to inference and normalization on pairwise undirected graphs of arbitrary topology (2005)

This paper presents a new sampling algorithm for approximating functions of variables representable as undirected graphical models of arbitrary connectivity with pairwise potentials, as well as for estimating the notoriously difficult partition function of the graph. The algorithm fits into the framework of sequential Monte Carlo methods rather than the more widely used MCMC, and relies on constructing a sequence of intermediate distributions which get closer to the desired one. While the idea of using tempered proposals is known, we construct a novel sequence of target distributions where, rather than dropping a global temperature parameter, we sequentially couple individual pairs of variables that are, initially, sampled exactly from a spanning tree of the variables. We present experimental results on inference and estimation of the partition function for sparse and densely-connected graphs.
Human Papillomaviruses and Papillomatosis Lesions of the Female Lower Genital Tract (1994)

These data suggest that nodular papillomatosis was closely associated with HPV infection, but that papular papillomatosis of the lower female genital tract may have an etiology other than HPV infection.
Cell communication and signaling: how to turn bad language into positive one (2019)

Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant sites. The crosstalk between neoplastic cells and accessory elements, such as immune and stromal cells, fosters several processes that are necessary for tumor progression and dissemination, such as angiogenesis, immune-escape, epithelial-to-mesenchymal transition, invasion and multi-drug resistance. There are several means by which cells communicate to each other, either by direct cell interactions through membrane receptors and ligands, or by releasing soluble molecules, such as growth factors, cytokines and chemokines. More recently, additional means of cell communication have been identified, such as microRNAs and extracellular vesicles. These two peculiar ways of cell-to-cell interaction were the focus of the 31st Annual Conference of the Italian Association of Cell Cultures (AICC).
Abstract 17061: Primary Pci Strategy for Non-st Elevation Acute Coronary Syndrome in Elderly Patients (>75y/o): An Analysis of the Aboard Study (2010)

Aim: The multicenter randomized ABOARD Study demonstrated that in Non ST-Elevation Acute Coronary Syndrome (NSTEACS) patients, a primary PCI strategy is feasible and associated with a shorter hospi...
TimeWarp: Rethinking timekeeping and performance monitoring mechanisms to mitigate side-channel attacks (2012)

Over the past two decades, several microarchitectural side channels have been exploited to create sophisticated security attacks. Solutions to this problem have mainly focused on fixing the source of leaks either by limiting the flow of information through the side channel by modifying hardware, or by refactoring vulnerable software to protect sensitive data from leaking. These solutions are reactive and not preventative: while the modifications may protect against a single attack, they do nothing to prevent future side channel attacks that exploit other microarchitectural side channels or exploit the same side channel in a novel way. In this paper we present a general mitigation strategy that focuses on the infrastructure used to measure side channel leaks rather than the source of leaks, and thus applies to all known and unknown microarchitectural side channel leaks. Our approach is to limit the fidelity of fine grain timekeeping and performance counters, making it difficult for an attacker to distinguish between different microarchitectural events, thus thwarting attacks. We demonstrate the strength of our proposed security modifications, and validate that our changes do not break existing software. Our proposed changes require minor - or in some cases, no - hardware modifications and do not result in any substantial performance degradation, yet offer the most comprehensive protection against microarchitectural side channels to date.
Domain Specific Ontology Extractor For Indian Languages (2012)

We present a k-partite graph learning algorithm for ontology extraction from unstructured text. The algorithm divides the initial set of terms into different partitions based on information content of the terms and then constructs ontology by detecting subsumption relation between terms in different partitions. This approach not only reduces the amount of computation required for ontology construction but also provides an additional level of term filtering. The experiments are conducted for Hindi and English and the performance is evaluated by comparing resulting ontology with manually constructed ontology for Health domain. We observe that our approach significantly improves the precision. The proposed approach does not require sophisticated NLP tools such as NER and parser and can be easily adopted for any language.
Preparation of actinides for .alpha. spectrometry without electrodeposition (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of actinides for .alpha. spectrometry without electrodepositionClaude W. Sill and Rodger L. WilliamsCite this: Anal. Chem. 1981, 53, 3, 412–415Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ac00226a008https://doi.org/10.1021/ac00226a008research-articleACS PublicationsRequest reuse permissionsArticle Views480Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studying a Signal due to the Tangential Component of Stray Fluxes from a Surface Flaw Detected with a Vibrating Induction Transducer (2018)

Analytical dependences of the amplitude spectrum of the output signal of a vibrating induction transducer on its position with respect to a flaw and on vibration-displacement parameters have been derived. The locality of inspection and its selective sensitivity toward flaws have been evaluated. The results of theoretical research have been confirmed experimentally.