gebhart/patrepeval huggingface dataset:
Formation of small negative and positive cluster ions of gold, silver, and copper by direct laser vaporization (1988)

Direct laser vaporization techniques have been employed to produce small cluster cations and anions of gold, silver, and copper in a Fourier transform ion cylotron resonance mass spectrometer using pure metal samples. Aupn (p=+1 and −1, n=1–6), Ag+n (n=1–3), Ag−, Cu+n (n=1–3), and Cu−n (n=1–2) were observed, using two different experimental configurations. In one configuration ions were produced by Nd:YAG laser irradiation directed collinear with the magnetic field in the FTICR mass spectrometer while in the second laser light directed perpendicularly to the magnetic field was used. Relative kinetic energies of the aggregates, the relative intensities of positive vs negative ions, and the nature of the neutrals in the plasma formed by direct laser vaporization are discussed.
Rapid Method for Detection of Gram-Positive and -Negative Bacteria in Milk from Cows with Moderate or Severe Clinical Mastitis (2001)

A rapid method for demonstration of gram-positive and gram-negative bacteria in milk is described. The technique is based on dilution of the sample in a medium, followed by filtration through a porous polysulfone membrane with a pore size retaining and concentrating bacteria from the sample. The bacteria concentrated on the surface of the membrane are stained with a cationic dye (toluidine blue) that can be visualized by the naked eye. After staining, the membrane is treated with ethanol-acetic acid (pH 2.8 to 3.0), which causes decolorization of gram-negative bacteria, whereas gram-positive bacteria retain the stain. The method does not require heat fixation, electrical power, microscopic examination, or specially trained personnel. The time needed to perform the test is approximately 5 min. The technique was applied to artificially infected milk and milk from cows with moderate or severe clinical mastitis for detection and differentiation of bacteria. The sensitivity of the filtration method was 92 and 100% for gram-positive and gram-negative bacteria, respectively, compared with traditional bacteriological culture of milk samples. The detection limit was 5 x 10(6) CFU/ml for Staphylococcus aureus and 1 x 10(6) CFU/ml for Escherichia coli in spiked milk samples. The overall specificity of the method was 86%. This diagnostic method can provide on-site guidance to the veterinarian to optimize use of antibiotics in mastitis therapy.
Seamless object tracking in distributed vision sensor network (2004)

Robots will be able to coexist with humans and support humans effectively in near future. We proposed the intelligent space in order to achieve such human-centered system. The intelligent space is the space where many intelligent devices, such as computers and sensors, are distributed. The intelligent space achieves the human centered services by accelerating the physical and psychological interaction between humans and intelligent devices. The intelligent space requires functions of identifying and tracking the multiple objects to realize appropriate services to users under the multi-camera environments. This paper describes color histogram based object tracking process for intelligent space to achieve seamless tracking and location estimation.
Morphological observations on rat livers perfused with a perfluorodecalin + N,N-perfluorodiethylcyclohexylamine emulsion having oxyphoretic properties. (1990)

Perfusion of Rat liver with an oxyphoretic emulsion containing a mixture of perfluorodecalin and N,N-perfluorodiethylcyclohexylamine provides a good oxygenation of the tissue. During perfusion hepatocytes take up some emulsion micelles and this uptake markedly increases when tissue perfusion is suboptimal.
Silent phase qubit based ond-wave Josephson junctions (2005)

A flux qubit is designed and fabricated that capitalizes on intrinsic properties of submicron YBCO (yttrium-barium-copper oxide high-${T}_{c}$ superconductor) grain boundary junctions. The operating point is protected from the fluctuations of the external fields, already on the classical level. The effects of external perturbations only appear in the third or fourth order, depending on the character of the coupling. The estimates of the decoherence due to fluctuations of the external flux show that an experimental observation of coherent quantum tunneling and Rabi oscillations in the system is feasible.
On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin (2018)

A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
E-Textile Conductors and Polymer Composites for Conformal Lightweight Antennas (2010)

We present a conformal and lightweight antenna technology based on E-textile conductors and polymer-ceramic composites. Unique advantages of the proposed technology are its structural integrity, light weight and conformity to the platform. E-textile conductors are fabricated with single wall carbon nanotube (SWNT) and Ag coated textiles. They demonstrate good structural integrity with polymer composites due to their mechanical compatibility. Similarly, polymer composites demonstrate superior RF performance with permittivity ranging from 3 to 13. Fabrication process for E-textile conductors and integration process with polymer composites is described in detail. We also demonstrated merit of the proposed technology with a simple patch antenna whose radiation performance is measured when it was flat and conformed onto a cylindrical surface. We compared its performance with that of an ideal patch. Experiments suggested that the sample patch antenna based on the proposed technique achieved 6 dB gain, which is 2 dB below a patch which has the same dimensions and made of ideal lossless materials. When it is conformed onto a cylindrical surface, we achieved 2.5 dB less gain than that of antenna realized with a PEC surface. This clearly validates the merit of the proposed conformal antenna technique based on non-traditional materials.
ASO silencing of a glycosyltransferase, Poglut1, improves the liver phenotypes in mouse models of Alagille syndrome (2023)

Our preclinical studies establish ASO-mediated POGLUT1 knockdown as a potential therapeutic strategy for ALGS liver disease and possibly other diseases associated with BD paucity.
Effect of polymer concentration on polarization switching in polysiloxane‐dispersed ferroelectric liquid crystals (2002)

Abstract Ferroelectric liquid crystal–polysiloxane composite films were prepared after dissolving them in diethyl ether as a solvent. The crosslinking was done by adding room temperature vulcanizer (mixture of tetra ethoxy silane and dibutyl tin dilaurate) as curing agent. These composite films show good electro‐optic properties with switching times on the order of few milliseconds. The preliminary results show that these systems can be useful as functional materials in electronic displays. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1209–1215, 2003
ChemInform Abstract: PALLADIUM(II)‐CATALYZED OXIDATIVE RING CLEAVAGE OF CYCLIC ACETALS WITH TERT‐BUTYL HYDROPEROXIDE: PREPARATION OF MONOESTERS OF DIOLS (1984)

Abstract Durch Oxidative Spaltung der cyclischen Acetale (I) erhält man die Hydroxycarbonsäureester (II).
A stochastic model of intonation for French text-to-speech synthesis (1997)

This paper presents a stochastic model of French intonation contours for use in text-to-speech synthesis. The model has two modules, a linguistic module that generates abstract prosodic labels from text, and a phonetic module that generates an F0 curve from the abstract prosodic labels. This model differs from previous work in the abstract prosodic labels used, which can be automatically derived from the training corpus. This feature makes it possible to use large corpora or several corpora of different speech styles, in addition to making it easy to adapt to new languages. The present paper focuses on the linguistic module, which does not require full syntactic analysis of the text but simply relies on a part-of-speech tagging technique. The results were validated by means of a perception test which showed that listeners did not perceive a significant difference in quality between the sentences synthesized with the original F0 curve (from a recording), and those synthesized with the model-generated curve. The proposed model thus appears to capture a large part of the grammatical information needed to generate F0.
Dispersion management in soft glass all-solid photonic crystal fibres (2012)

Abstract The development of all-solid photonic crystal fibres for nonlinear optics is an alternative approach to air-glass solid core photonic crystal fibres. The use of soft glasses ensures a high refractive index contrast (&gt; 0.1) and a high nonlinear coefficient of the fibres. We report on the dispersion management capabilities in all-solid photonic crystal fibres taking into account four thermally matched glasses which can be jointly processed using the stack-and-draw fibre technique. We present structures with over 450 nm broadband flat normal dispersion and ultra-flat near zero anomalous dispersion below 5 ps/nm/km over 300 nm dedicated to supercontinuum generation with 1540 nm laser sources. The development of an all-solid photonic crystal fibre made of F2 and NC21 glasses is presented. The fibre is used to demonstrate supercontinuum generation in the range of 730–870 nm (150 nm) with flatness below 5 dB.
Brief alcohol screening in a clinical psychiatric population: Special attention needed (2011)

The findings of this study suggest that the HED screener is not sensitive enough in the clinical psychiatric setting. When designing alcohol screening measures to be used all over health-care organisations, special attention should be paid to psychiatric patients. If a somewhat more extensive screening tool is used, the full AUDIT is recommended.
Optimum angles for a polarimeter: part I (1995)

The four optimum rotation angles for a polarimeter consisting of a quarter-wave plate in conjunction with a linear polarizer are found. This is done by using the determinant and condition numbers of the system measurement matrix as objective functions in a minimization procedure. The four angles so found result in the polarimeter's estimate of the incident Stokes vector to have a minimum sensitivity with respect to fluctuations in the detected flux and errors in the angular position of the optical components constituting the polarimeter. Four optimal angles are presented. These four angles also retain a simplicity of form for the measurement matrix.
Peptide boronic acids Versatile synthetic ligands for affinity chromatography of serine proteinases* (1996)

Peptide boronic acids are potent transition-state analogue inhibitors of serine proteinases. We prepared the peptide boronic acids Ala-Ala-boroPhe (AAbF), targeted at chymotrypsin-like proteinases, and Ala-Ala-boroVal (AAbV), targeted at elastolytic enzymes. Analogues protected on the N-terminus with the carbonylbenzyloxy (Cbz) group were powerful inhibitors of human neutrophil elastase (HNE) and human cathepsin G (CatG), as well as the non-human counterparts, porcine pancreatic elastase (PPE) and bovine alpha-chymotrypsin (ChT) Removal of N-Cbz protecting groups and immobilization with Sepharose 6B provided affinity matrices. Columns consisting of the AAbF or AAbV affinity matrix separated a mixture of PPE and ChT. PPE was specifically retained by the AAbV column and ChT was specifically retained by the AAbF column. HNE and CatG were not separated using the AAbF matrix, but were separated with the AAbV matrix. To demonstrate the practical utility of these affinity ligands, HNE was isolated from crude human neutrophil extracts, resulting in an 18-fold purification in one chromatographic step, with a 41% recovery of elastolytic activity. Because peptide boronic acids can be synthesized having specificity for a wide range of target enzymes, this method is readily adaptable as a general procedure for isolation and purification of serine proteinases.
Report from the 1st MYCOKEY International Conference Global Mycotoxin Reduction in the Food and Feed Chain Held in Ghent, Belgium, 11–14 September 2017 (2017)

This conference is organized within the framework of the H2020-Research and Innovation Action-Societal Challenge 2-"Food security, sustainable agriculture and forestry, marine, maritime and inland water research and the bioeconomy challenge"-GA 678781 MycoKey "Integrated and innovative key actions for mycotoxin management in the food and feed chain" [...].
Nonlinearity Mitigation Using a Machine Learning Detector Based on <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math> </inline-formula>-Nearest Neighbors (2016)

A powerful machine learning detector based on the k-nearest neighbors (KNN) algorithm is proposed to overcome system impairments. The zero-dispersion link (ZDL), dispersion managed link (DML), and dispersion unmanaged link (DUL) are considered. Meanwhile, an improved algorithm, the distance-weight KNN, is introduced, which outperforms the conventional maximum likelihood-post compensation approach. The numerical results show that KNN is feasible for overcoming various impairments, especially for non-Gaussian symmetric noise, such as laser phase noise and nonlinear phase noise in the ZDL or DML.
Properties and structural characterization of the mixed-ligand complex oxydiacetato(2,2′:6′,2″-terpyridyl)copper(II) dihydrate (1983)

The crystal structure of the title complex has been determined by X-ray methods. Crystals are monoclinic, space group P21/c with Z= 4 in a unit cell of dimensions a= 10.681(6), b= 22.44(1), c= 11.534(6)Å, and β= 136.1(2)°. The complex has a distorted octahedral stereochemistry with the two ligands co-ordinating in two approximately perpendicular planes.
pH-Responsive Polymeric siRNA Carriers Sensitize Multidrug Resistant Ovarian Cancer Cells to Doxorubicin via Knockdown of Polo-like Kinase 1 (2010)

Small interfering RNA (siRNA)-based therapies have great potential for the treatment of debilitating diseases such as cancer, but an effective delivery strategy for siRNA is elusive. Here, pH-responsive complexes were developed for the delivery of siRNA in order to sensitize drug-resistant ovarian cancer cells (NCI/ADR-RES) to doxorubicin. The electrostatic complexes consisted of a cationic micelle used as a nucleating core, siRNA, and a pH-responsive endosomolytic polymer. Cationic micelles were formed from diblock copolymers of dimethylaminoethyl methacrylate (pDMAEMA) and butyl methacrylate (pDbB). The hydrophobic butyl core mediated micelle formation while the positively charged pDMAEMA corona enabled siRNA condensation. To enhance cytosolic delivery through endosomal release, a pH-responsive copolymer of poly(styrene-alt-maleic anhydride) (pSMA) was electrostatically complexed with the positively charged siRNA/micelle to form a ternary complex. Complexes exhibited size (30-105 nm) and charge (slightly positive) properties important for endocytosis and were found to be noncytotoxic and mediate uptake in >70% of ovarian cancer cells after 1 h of incubation. The pH-responsive ternary complexes were used to deliver siRNA against polo-like kinase 1 (plk1), a gene upregulated in many cancers and responsible for cell cycle progression, to ovarian cancer cell lines. Treatment resulted in approximately 50% reduction of plk1 gene expression in the drug-resistant NCI/ADR-RES ovarian cancer cell model and in the drug-sensitive parental cell line, OVCAR8. This knockdown functionally sensitized NCI/ADR-RES cells to doxorubicin at levels similar to OVCAR8. Sensitization occurred through a p53 signaling pathway, as indicated by caspase 3/7 upregulation following plk1 knockdown and doxorubicin treatment, and this effect could be abrogated using a p53 inhibitor. To demonstrate the potential for dual delivery from this polymer system, micelle cores were subsequently loaded with doxorubicin and utilized in ternary complexes to achieve cell sensitization through simultaneous siRNA and drug delivery from a single carrier. These results show knockdown of plk1 results in sensitization of multidrug resistant cells to doxorubicin, and this combination of gene silencing and small molecule drug delivery may prove useful to achieve potent therapeutic effects.
Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides. (1984)

The complete nucleotide sequence of a human interferon-alpha gene is reported. The gene, designated IFN-alpha M1, was isolated from a human genomic library in phage lambda Charon 4A using synthetic oligonucleotides as hybridization probes. Based on a comparison of nucleotide sequence data obtained from this recombinant phage with published interferon-alpha gene sequences, a region of DNA capable of coding for a pre-interferon of 189 amino acids was identified. An AluI fragment containing the coding region for the mature interferon was inserted into the HincII site of the phage M13mp11, resulting in a fusion of portions of the IFN-alpha M1 and the beta-galactosidase genes. Antiviral activity was detected in extracts from E. coli infected with the recombinant M13 phage carrying the fused gene. The antiviral activity was completely neutralized by antibodies to human interferon-alpha.
Grain Boundary Property Determination through Measurement of Triple Junction Geometry and Crystallography (2006)

This work was supported primarily by the MRSEC program of the National Science Foundation under Award Number DMR-0079996. Microstructure controls the properties of most useful materials. Thus an ability to control microstructure through the processing of materials is a key to optimization of materials performance. Most materials are polycrystalline and their grain structure is a very important aspect of their microstructure. Thanks to their complexity there is a great variety of grain boundary types even in relatively isotropic materials such as the cubic metals. Simply describing the crystallography requires five (macroscopic) parameters (e.g. disorientation and inclination). Evidently, acquiring a knowledge of the variation of properties such as energy and mobility as a function of grain boundary type would be of great value in predicting properties and optimizing processing. This paper outlines the methods being employed to extract such properties from the geometry and crystallography of triple junctions between grain boundaries.
Self-consistent field theory simulations of block copolymer assembly on a sphere (2007)

Recently there has been a strong interest in the area of defect formation in ordered structures on curved surfaces. Here we explore the closely related topic of self-assembly in thin block copolymer melt films confined to the surface of a sphere. Our study is based on a self-consistent field theory (SCFT) model of block copolymers that is numerically simulated by spectral collocation with a spherical harmonic basis and an extension of the Rasmussen-Kalosakas operator splitting algorithm [J. Polym. Sci. Part B: Polym. Phys. 40, 1777 (2002)]. In this model, we assume that the composition of the thin block copolymer film varies only in longitude and colatitude and is constant in the radial direction. Using this approach we are able to study the formation of defects in the lamellar and cylindrical phases, and their dependence on sphere radius. Specifically, we compute ground-state (i.e., lowest-energy) configurations on the sphere for both the cylindrical and lamellar phases. Grain boundary scars are also observed in our simulations of the cylindrical phase when the sphere radius surpasses a threshold value R_{c} approximately 5d , where d is the natural lattice spacing of the cylindrical phase, which is consistent with theoretical predictions [Bowick, Phys. Rev. B 62, 8738 (2000); Bausch, Science 299, 1716 (2003)]. A strong segregation limit approximate free energy is also presented, along with simple microdomain packing arguments, to shed light on the observed SCFT simulation results.
An improved algorithm for high speed autocorrelation with applications to spectral estimation (1970)

A common application of the method of high speed convolution and correlation is the computation of autocorrelation functions, most commonly used in the estimation of power spectra. In this case the number of lags for which the autocorrelation function must be computed is small compared to the length of the data sequence available. The classic paper by Stockham, revealing the method of high speed convolution and correlation, also discloses a number of improvements in the method for the case where only a small number of lag values are desired, and for the case where a data sequence is extremely long. In this paper, the special case of autocorrelation is further examined. An important simplification is noted, based on the linearity of the discrete Fourier transform, and the circular shifting properties of discrete Fourier transforms. The techniques disclosed here should be especially important in real-time estimation of power spectra, in instances where the data sequence is essentially unterminated.
Simulation of Flow Transients in a Water Filling Pipe Containing Entrapped Air Pocket with VOF Model (2011)

Abstract:he pressure within an entrapped air pocket in a filling pipeline without air release is investigated both experimentally and numerically. Volume of Fluid (VOF) model is introduced to simulate the transient flow. Both VOF model and experimental observations show that the air-water interface moves irregularly, and the water column near bottom pipe wall firstly reaches and impacts on pipe end wall, which could induce a sudden pressure jump. Due to assumptions of "air pocket occupies entire cross section" and "air-water interface is perpendicular to pipe centerline", the existing one-dimensional model is incapable of calculating the jump pressure. Comparisons between calculated and measured results demonstrate that VOF model is effective to simulate movement of air pocket and pressure surge. In a one-dimensional model, only the first peak pressure is close to the measured value, but the following peak pressures are not. Therefore, VOF model is a feasible and more advanced method to investigate further this problem.Keywords: transient flowwater pipelineentrapped air pocketVOF model1D elastic modelpressure jump
A Method for the Kinematic Evaluation of the Knee following Anterior Cruciate Ligament Injury and Reconstruction (1993)

A quantitative method for assessing the kinematics of the knee in the sagittal plane has been developed in order to evaluate the role of the anterior cruciate ligament following injury and reconstruction. Measurements were made on a series of lateral radiographs obtained at different angles of flexion with the limb weight-bearing and the foot and ankle rotated so that the condyles of the femur overlapped. The kinematics of the joint were then defined by recording the path of the tip of the medial tibial spine as flexion proceeded, using a coordinate system based on the femur. This method overcomes the problems inherent in quantifying knee kinematics by using the pathway of the centre of rotation. In an amputated knee, tibial positions could be specified to within approximately 1.2 mm. There were no significant differences between results obtained at the beginning and end of a six month period for the normal knees of two patients; the standard deviation of the measured tibial positions was approximately 1.6 mm.