gebhart/patrepeval huggingface dataset:
Detection of HTLV-1 replication and CD4+ proliferation in the humanized BLT mouse model (2015)

Human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL) and a number of lymphocyte-mediated inflammatory conditions including HTLV-1–associated myelopathy/tropical spastic paraparesis. Development of animal models to study the pathogenesis of HTLV-1–associated diseases has been problematic and the mechanisms driving disease remain poorly understood. Here we report our findings of HTLV-1 infection in humanized nonobese diabetic (NOD) severe combined immunodeficiency (SCID) common gamma chain knockout (NSG) mice that have been implanted with fetal bone marrow-liver-thymus tissue (BLT). BLT mice were injected with lethally irradiated CD4+ HTLV-1 producing cells. Blood samples were collected every four weeks to monitor CD4 and CD8 phenotypes and DNA isolation. Concomitant with an increase in the number of CD4+CD25+ T-lymphocytes in exposed animals compared to controls, we observed a significant increase in the HTLV-1 viral DNA load. Surprisingly, unlike what we observed in macaques, HTLV-1 virus mutated to knockout Orf-I protein expression was able to infect BLT mice and high viral DNA loads were detected. However, after sequencing the orf-I region of proviral DNA from infected animals, we found reversion of the point mutation to wild type. This was observed as early as four weeks after exposure, indicating in vivo viral replication and selection for Orf-I expression. Thus, the BLT mouse model successfully recapitulates HTLV-1 infection and may serve as an important tool for investigating in vivo mechanisms of HTLV-1 disease pathology and in evaluating drugs and treatment strategies.
Dimeric Inhibin A as a Fourth Marker for Down's Syndrome Maternal Serum Screening in Native Japanese Women (2000)

This report shows for the first time that dimeric inhibin A can be informative as a fourth marker for Down's syndrome screening in native Japanese women. We expect the addition of dimeric inhibin A to a triple marker protocol will increase the accuracy of predicted risk for all pregnancies screened and increase the detection rate of Down's syndrome affected pregnancies.
Energy-efficient skewed static logic design with dual Vt (2002)

In this paper, we describe skewed static logic (S/sup 2/L) with topology-dependent dual Vt which exhibits energy-efficient operation. S/sup 2/L consumes less dynamic and static power compared to Monotonic Static (MS) CMOS. Speed degradation of S/sup 2/L can be offset by the accelerator. We have designed NAND-NOR gate chains using 0.18 /spl mu/m CMOS technology and verified that S/sup 2/L reduces energy/spl times/delay over MS CMOS by 27-50%. Synthesis algorithm for S/sup 2/L developed and the experimental results show S/sup 2/L consumes 23% less power than MS CMOS with minor increase in delay.
1P1-O04 Development of a MEMS Capacitive Ultrasonic Sensor Usable for Both Receiver and Transmitter Having Parylene Diaphragm (2007)

The final goal of this research is to develop a condenser type micro ultrasonic sensor, which would be used as both receiver and transmitter. Polymer diaphragm is flexible and non-brittle, allowing good sensitivity and durability. Besides that, Parylene has good C-MOS compatibility, since it can be deposited at room temperature. Based on the FEM simulation results on the resonant frequency under tensile stress of Parylene, the diaphragm radius of 500〜1200 μm is employed to realize the bandwidth up to ultrasonic range of 40〜100 kHz. The influence of the number and the radius of acoustic holes on damping ratio is investigated by FEM simulation, in order to achieve a moderate damping of the diaphragm. Practical sensor devices are fabricated. They can receive an impulsive ultrasonic pulse transmitted by a spark discharge. The open-circuit sensitivity is 0.3 mV/Pa, in reference to B&K 4138 microphone. The ranging system using this sensor can detect the distance up to 1 m with the error less than 1 mm. The developed sensor can be approximated to be non-directional.
Idiopathic adult‐onset nemaline myopathy presenting with isolated respiratory failure (2009)

Idiopathic adult-onset nemaline myopathy is a rare condition of unknown etiology that usually presents with proximal weakness. This case study reports a 60-year-old woman who presented with isolated type 2 respiratory failure secondary to bilateral hemidiaphragm weakness. A left vastus medialis muscle biopsy examined under light microscopy revealed appearances typical of nemaline myopathy. Electron microscopy confirmed the presence of nemaline rods in most muscle fibers, thus establishing idiopathic adult-onset nemaline myopathy as the cause of her respiratory failure. Our patient's presentation highlights the importance of considering neuromuscular weakness as a cause of respiratory failure. Unless appropriate tests are performed-including a muscle biopsy, if indicated-specific neuromuscular diseases are easily missed. This can lead to inappropriate counseling and treatment.
Applications of a low-cost level III interactive videodisc system for engineering education (2003)

An overview is presented of a low-cost level III system (consisting of a computer-controlled videodisc player) for improving instructional delivery. This system provides the capability of superimposing computer and video displays and allows for transmitting the display to a room full of ordinary television monitors. Application software that allows easy preparation of video-enhanced lectures and videodisc-based interactive instructional materials is described. The level III system combines a one-megabyte, 32-bit computer (the Amiga 2000) with an industrial model videodisc player.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
BRIDGE: Bridging Warfarin With LMWH Increases Bleeding in Patients With AF (2015)

In the BRIDGE trial, bridging with low molecular weight heparin in patients with atrial fibrillation who underwent surgery or an invasive procedure that required warfarin interruption resulted in similar rates of arterial thromboembolism but significantly higher rates of minor and major bleeding.
Hydrodynamic Manipulation of Nano-Objects by Thermo-Osmotic Flows (2021)

The manipulation of micro- and nano-objects is of great technological significance to construct new materials, manipulate tiny amounts of liquids in fluidic systems, or detect minute concentrations of analytes. It is commonly approached by the generation of potential energy landscapes, for example, with optical fields. Here we show that strong hydrodynamic boundary flows enable the trapping and manipulation of nano-objects near surfaces. These thermo-osmotic flows are induced by modulating the van der Waals interaction at a solid-liquid interface with optically induced temperature fields. We use a thin gold film on a glass substrate to provide localized but reconfigurable point-like optical heating. Convergent boundary flows with velocities of tens of micrometres per second are observed and substantiated by a quantitative physical model. The hydrodynamic forces acting on suspended nanoparticles and attractive van der Waals or depletion induced forces to enable precise positioning and guiding of the nanoparticles. Fast multiplexing of flow fields further provides the means for parallel manipulation of many nano-objects. Our findings have direct consequences for the field of plasmonic nano-tweezers and other thermo-plasmonic trapping schemes and pave the way for a general scheme of nanoscopic manipulation with boundary flows.
Ionic structural transitions in perfluorosulfonate ionomers (1980)

Abstract An experimental and theoretical effort has been made to determine the ionic-hydrate molecular architecture within the hydrophilic clusters of perfluorosulfonate ionomers and environmentally induced structural transitions in these regions. The sidechain-counterion association-dissociation equilibrium in poly-electrolyte gels, as well as ion pairing in electrolyte solutions, has been recognized. It is appropriate to possess a theoretical molecular-based analysis of this equilibrium. FTIR and NMR spectroscopies have been used to monitor counterion associations in perfluorosulfonate salts. The onset of spectral changes with decreasing water content has been attributed to an increasing population of counterions that strongly interact with the sulfonate moiety. A statistical mechanical model, motivated by a formerly proposed multistep mechanism for the dissociation of ion pairs in simple electrolytes, is based on a four-state representation of counterion-sidechain association. The relative populations of these states depend on solvation and interionic energy formulations. The calculated shift in the spectrum of states with decreasing water content is entirely consistent with the conceptual model arising from spectroscopic interpretation. FTIR spectra of those ionomers that had been equilibrated in concentrated alkali hydroxide solutions have indicated the presence of a tunneling of protons that displays transitional behavior with ionic strength variance. In addition, polymer morphology-related aspects of the internal hydrogen bond structure have been noted.
INTRAMUSCULAR ADMINISTRATION OF 15‐METHYL PROSTAGLANDIN F2α FOR INDUCTION OF LABOUR IN PATIENTS WITH INTRAUTERINE FETAL DEATH OR AN ANENCEPHALIC FETUS (1976)

The 15-methyl analogue of PGF2alpha was administered intramuscularly between 23 and 36 weeks of gestation, to induce labour in 11 mothers with intrauterine fetal death and two with anencephaly. All were delivered within 20 hours (mean 7 hours). The mean dose of 15-me-PGF2alpha was 400 mug (range 100 to 700) given by a mean of 3-1 (range 1 to 7) injections. Diarrhoea was the most frequent side-effect.
Factors Affecting the Intention to Adopt Electronic Bill Presentation and Payment (2003)

Electronic Bill Presentation and Payment (EBPP) is a technology that is slowly gaining acceptance by consumers.The study intends to investigate the factors that affect adoption intentions of consumers.The attitudinal, social and behavioral factors, based on the decomposed Theory of Planned Behavior Model, which may influence the intention to adopt, will be determined.
Long-arm two-color interferometer for measuring the change of air refractive index (1990)

This paper presents a two-color optical path-1ength-cdulated reversible fringe-counting interferometer system for iieasuring the change of the air refractive index. By measuring the changes of the optical path for infrared and visible light the interferoieter cancels the effect of the geoietrical distance change. This system is being tested over a 235 ii path in the tunnel at NRLM. 1.
Calibration of a class of 3 DOF serial micro robotic systems through SEM vision: application to vertical AFM tip landing (2019)

When performing manipulation at small scales, the micro-robotic system and the vision system axes often aren't aligned, leading to low accuracy. To asses this issue it is possible to manually align the manipulator axes to the ones of the vision system or to calibrate the robot coordinate system with respect to the vision coordinate system. Manual alignment is a tedious procedure that requires no computation, however its performance is directly linked to the operator's experience. Calibration on the other end aims at compensating the misalignment by adjusting control laws or actuator references. In this paper a new methodology for the calibration of a class of 3 DOF serial micro-robots inside a Scanning Electron Microscope (SEM) is presented. This methodology presents the advantage of taking few assumptions about the robot, only requiring an imaging system performing an affine projection of the scene thus being applicable to a large class of systems. Moreover the proposed methodology allow the robot to move in a straight line orthogonal to the image plane, which can be used for peg-on-hole operations. The method is first tested in simulation and then is applied on a 3 DOF micromanipulator under a SEM for AFM tip landing on selected red blood cells. Theory and practice provide accurate results even in the presence of significant misalignment between robot and vision axes. Finally, some conclusions are drawn.
Gout and hyperuricemia (1997)

Although there continue to be relatively few basic studies of the metabolism and transport of urate, clinical interest in gout and hyperuricemia remains high. A number of interesting new observations are described here from the published literature of the past year. Various aspects of the diagnosis, management, and pathophysiology of gout and gouty arthritis have been recently reviewed. The therapy of gout and hyperuricemia continue to lead to significant complications.
Detecting the Site of Phosphorylation in Phosphopeptides without Loss of Phosphate Group Using MALDI TOF Mass Spectrometry (2008)

Phosphopeptides with one and four phosphate groups were characterized by MALDI mass spectrometry. The molecular ion of monophosphopeptide could be detected both as positive and negative ions by MALDI TOF with delayed extraction (DE) and in the reflector mode. The tetraphospho peptide could be detected in linear mode. When MS/MS spectra of the monophospho peptides were obtained in a MALDI TOF TOF instrument by CID, b and y ions with the intact phosphate group were observed, in addition the b and y ions without the phosphate group. Our study indicates that it is possible to detect phosphorylated peptides with out the loss of phosphate group by MALDI TOF as well as MALDI TOF TOF instruments with delayed extraction and in the reflector mode.
Parallel methods for the numerical integration of ordinary differential equations (1967)

In this paper we derive a class of numerical integration formulas of a parallel type for ordinary differential equations. These formulas may be used simultaneously on a set of arithmetic processors to increase the integration speed. Conditions for the convergence of such formulas are formulated. Explicit examples for two and four processor cases are derived. Results of numerical experiments are given which show an effective improvement in computation speed.
On cloaking for elasticity and physical equations with a transformation invariant form (2006)

International audience
[The effect of a calcium carbonate-bismuth subsalicylate combination on intragastric acidity over the course of 24 hours. A randomized study of healthy probands]. (1989)

Bismuth salts are successfully used for the treatment of campylobacter-pylori-associated gastritis. It cannot be excluded, however, that calcium carbonate, which is present in one of the recommended preparations (calcium carbonate/bismuth subsalicylate, Jatrox), may have an additional therapeutic effect due to an increase of intragastric pH. Therefore, the in-vitro H+ buffering capacity of Jatrox was determined in comparison to other antacids using the pH-stat technique, and its effect on intragastric acidity was tested in 15 healthy volunteers using ambulatory 24-hour pH-metry (combined glass electrode in gastric corpus, solid state memory recorder, sampling rate 30/min). At two study sessions, the volunteers received standardized normal meals (8:00 a.m., 12:00 noon, 6:00 p.m.) and, in randomized order, either Jatrox (three times 2 tablets one hour before meals) or no medication. Under in-vitro conditions, the buffering capacity of Jatrox amounts to 7.82 mmol H+ per tablet (equivalent to 47 mmol H+/24 h at recommended dosage), which is relatively low. Under in-vivo conditions, gastric pH only increases significantly during the first hour after medication. This short-lasting effect, however, has no influence on the 24-hour median pH. It is concluded from these results that the calcium carbonate contained in Jatrox probably does not contribute directly towards its therapeutic effect in promoting the healing of gastritis.
CAST constraints on the axion-electron coupling (2013)

In non-hadronic axion models, which have a tree-level axion-electron interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton scattering, and axio-recombination, the "BCA processes." Based on a new calculation of this flux, including for the first time axio-recombination, we derive limits on the axion-electron Yukawa coupling g_ae and axion-photon interaction strength g_ag using the CAST phase-I data (vacuum phase). For m_a < 10 meV/c2 we find g_ag x g_ae< 8.1 x 10^-23 GeV^-1 at 95% CL. We stress that a next-generation axion helioscope such as the proposed IAXO could push this sensitivity into a range beyond stellar energy-loss limits and test the hypothesis that white-dwarf cooling is dominated by axion emission.
Influence of ligand field stabilization energy on the elastic properties of multiferroic MOFs with the perovskite architecture (2012)

We report the mechanical properties of four isostructural metal-organic frameworks (MOFs) that adopt the ABX(3) perovskite topology: [(CH(3))(2)NH(2)]M(HCOO)(3), where M = divalent Mn, Co, Ni, and Zn. Their Young's moduli were measured via single-crystal nanoindentation. We show that the mechanical stability of such isostructural frameworks with octahedral coordination increases with greater ligand field stabilization energy (LFSE).
Targeting the Heart Using in vivo Phage Display (2009)

Background: Ischemic heart disease remains the number one killer in the developed world. A protein transduction peptide specific for the heart capable of efficiently delivering agents of therapeutic potential at the time of injury, would be of immense public health significance. This work was undertaken to identify peptide(s) able to transduce heart tissue in vivo in a tissue-specific manner. Biopanning was performed in cell culture followed by in vivo with an M13 phage peptide display library. Using the heart-specific peptide, we delivered nemo-binding domain peptide in a murine infarct model to test if NF-kB inhibition can reduce infarct size.Methods and Results: A cardiomyoblast cell line, H9C2, was incubated with M13 twelve amino acid phage peptide display library. Internalized phage was recovered, amplified and subjected to a total of three rounds of in vivo biopanning where infectious, internalized phage was isolated from cardiac tissue following intravenous injection. After the third round, 60% of sequenced plaques carried the peptide sequence APWHLSSQYSRT, termed cardiac targeting peptide (CTP). This peptide was synthesized either fluorescently labeled, biotinylated, or in combination with a NEMO-binding peptide (NBD), an inhibitor of the inducible NF-kappa B Kinase (IKK). We demonstrate that CTP was able to transduce cardiomyocytes functionally in culture in a concentration and cell-type dependent manner. Mice injected with CTP showed significant transduction of heart tissue with minimal uptake by lung and kidney capillaries, and no uptake in liver, skeletal muscle, spleen or brain. The level of heart transduction by CTP also was not observed with a cationic transduction domain. CTP-NBD was able to inhibit NF-kB activation in cell culture in a dose-dependent fashion. When administered to mice in a murine infarct model, CTP-NBD showed a trend towards smaller infarct size, which did not reach statistical significance. Conclusions: Biopanning using a peptide phage display library identified a peptide, termed CTP, able to transduce cardiomyoblast cell line in vitro, and heart tissue in vivo, efficiently and specifically. Administration of CTP-NBD to post-infarct mice showed a trend towards reduction of infarct size. CTP could be used to deliver therapeutic peptides, proteins and nucleic acid specifically to the heart.
One-Step Multiple Addition of Amine to [60]Fullerene. Synthesis of Tetra(amino)fullerene Epoxide under Photochemical Aerobic Conditions (2000)

A secondary amine undergoes a one-step multiple addition to [60]fullerene under photochemical aerobic conditions to produce tetra(amino)fullerene epoxide 1 in moderate to excellent yield.
An ESR study of titanium(III)-exchanged zeolite A (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn ESR study of titanium(III)-exchanged zeolite ASteven M. Kuznicki, K. Larry DeVries, and Edward M. EyringCite this: J. Phys. Chem. 1980, 84, 5, 535–537Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/j100442a018https://doi.org/10.1021/j100442a018research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
High Q defected ground structures in grounded coplanar waveguide (2012)

The correlation between the placement of spiral defected ground structures in each ground plane of a grounded coplanar waveguide and the corresponding frequency response are investigated. S-parameters and current density plots from an EM-based simulation study are examined to understand this relationship. Simulation and measurement results show that the highest rejection is obtained when placing defected ground structures in both the top and the bottom ground planes. Furthermore, placing unique defects in both ground planes allows the design of dual-behaviour resonators.
Energy-Efficient Power Allocation for UAV Cognitive Radio Systems (2017)

We study the deployment of unmanned aerial vehicles (UAV) based cognitive system in an area covered by the primary network (PN). An UAV shares the spectrum of the PN and aims to maximize its energy efficiency (EE) by optimizing the transmit power. We focus on the case where the UAV simultaneously communicates with the ground receiver (G), under interference limitation, and with another relaying UAV (A), with a minimal required rate. We analytically develop the power allocation framework that maximizes the EE subject to power budget, interference, and minimal rate constraints. In the numerical results, we show that the minimal rate may cause a transmission outage at low power budget values. We also highlighted the existence of optimal altitudes given the UAV location with respect to the different other terminals.