gebhart/patrepeval huggingface dataset:
Abstract 1424: KCNJ2 comprises a marker of poor prognosis and a therapeutic target in non-WNT/non-SHH medulloblastoma (2012)

Abstract Medulloblastoma comprises the most common malignant brain tumor in childhood. Recently, integrated genomic approaches revealed four major biological disease variants: WNT (wingless), SHH (sonic hedgehog), group 3, and group 4. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk non-WNT/non-SHH medulloblastoma. Thus, novel therapeutic options for these patients are urgently warranted. Through mRNA expression profiling of 64 primary tumor samples, we identified potassium inwardly-rectifying channel J2 (KCNJ2) as one of the most upregulated genes on chromosome 17q in tumors with 17q gain. Notably, recent reports have linked deregulation of voltage-dependent ion channels to the development of other types of cancer. We first validated our microarray findings on KCNJ2 transcript levels using quantitative real-time PCR. High KCNJ2 transcript levels were significantly associated with non-WNT/non-SHH grouping, anaplastic histology, metastatic dissemination, and poor clinical outcome. KCNJ2 protein expression was analyzed by immunohistochemistry in a large cohort of patients (n=199), and high protein expression levels were found to be strongly correlated with 17q gain, metastatic dissemination, and inferior overall and progression-free survival (p&amp;lt;0.0001). To functionally validate the potential role of KCNJ2 in medulloblastoma biology, we performed knockdown experiments by small interfering RNA-mediated silencing in two well characterized medulloblastoma cell lines. Knockdown of KCNJ2 resulted in a reduced proliferation rate and induction of apoptosis. Furthermore, treatment of the medulloblastoma cell lines with Amiodarone and SR 59230A, two inhibitors of this class of Kir channels, phenocopied these promising anti-proliferative and pro-apoptotic effects in a time- and dose-dependent manner. Whole cell patch clamp results revealed a remarkable current reduction upon inhibitor treatment with SR 59230A. In summary, we could delineate KCNJ2 immunopositivity as an independent biomarker for medulloblastoma with dismal prognosis. Thus, pharmacological inhibition of this candidate gene may constitute a new therapeutic option for patients with high-risk medulloblastomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1424. doi:1538-7445.AM2012-1424
Trigon Based Authentication Service Creation with Globus Middleware (2011)

A Grid allows its constituent resources to be used in a coordinated fashion to deliver various qualities of service, relating for example to response time, throughput, availability, and security, and/or co-allocation of multiple resource types to meet complex user demands, so that the utility of the combined system is significantly greater than that of the sum of its parts. Security is a major concern as a grid enables sharing of valuable resources and sensitive information across heterogeneous users. Authentication, message integrity and confidentiality are the major concerns in grid security. The proposed approach uses a trigon based authentication and authorization of the grid entities. Grid service is stateful and transient web service, which can be invoked by clients, and is considered to be the mainstream of future internet. A service is defined by identifying sequences of specific message exchanges that cause the service to perform some operation. By thus defining these operations only in terms of message exchange, we achieve great flexibility in how services are implemented and where they may be located.The creation of Web Services standards is an industry-led initiative, with some of the emerging standards in various states of progress through the World Wide Web Consortium (W3C). The security protocol has been implemented and tested using Globus middleware. To achieve reuse of behaviors of this authentication concept, operations are often grouped together to form a SHA based authentication service using prerequisites as build.xml , globus-build-service.sh, WSDL file and globus as middleware.
Cover Feature: Polymers Based on Cyclic Carbonates as Trait d'Union Between Polymer Chemistry and Sustainable CO2 Utilization (ChemSusChem 4/2019) (2019)

The Cover Feature shows five-membered cyclic organic carbonate monomers strategically placed at the heart of a process that combines renewable, naturally available building blocks with abundantly available waste CO2 for the synthesis of polymers. In this way, cyclic carbonates play a pivotal role in connecting sustainable chemistry with the synthesis of everyday-life materials represented by foams, adhesives and components of lithium batteries”. More information can be found in the Review by Neha Yadav et al. on page 724 in Issue 4, 2019 (DOI: 10.1002/cssc.201802770).
Energy-Efficient Virtual Machine Consolidation (2013)

A novel approach to virtual machine (VM) consolidation, based on energy-efficient storage migration and live VM migration, is implemented using Eucalyptus, an open source clone of the Amazon Elastic Compute Cloud. Several experiments demonstrate the potential energy savings.
Inferring 3-D shapes from 2-D codons (1985)

All plane curves can be described at an abstract level by a sequence of five primitive elemental shapes, called codons, which simply capture the relations between the extrema of curvature. The codon description provides a basis for enumerating all smooth 2-D curves. Let each of these smooth plane curves be considered as the silhouette of an opaque 3-D object. Clearly an infinity of 3-D objects can generate any one of our codon silhouettes. How then can we predict which 3-D object corresponds to a given 2-D silhouette? To restrict the infinity of choices, we impose two mathematical properties of smooth surfaces plus one simple viewing constraint. The constraint is an extension of the notion of general position and seems to drive our preferred inferences of 3-D shapes, given only the 2-D contour.
Secretory IgA response in oral immunotherapy (1994)

A rationale for oral immunotherapy (OIT) might be founded on two potential mechanisms: induction of a mucosal secretory IgA response, or induction of systemic hyporesponsiveness (oral tolerance). Previous studies have shown clinically that there is a beneficial effect of OIT in birch pollinosis, in both children and adults. During OIT, birch pollen antigens in enterocoated capsules were given to 20 adults (participating in a double-blind, placebo-controlled trial) and 10 children, all suffering from birch pollinosis. Saliva and tears (only adults) samples were collected before, during, and after OIT. Each sample was assayed for both IgA antibodies against birch pollen antigens and total IgA by enzyme-linked immunosorbent assay. IgA antibody levels were also expressed in relation to total IgA concentrations, to correct for variations in secretion and flow rate between subjects and at different times. Changes in birch-specific secretory IgA antibodies in saliva and tears could not explain the beneficial effect of OIT in birch pollinosis. Further studies in this field are warranted.
Application of digital micromirror devices for spectral-response characterization of solar cells and photovoltaics (2010)

A key parameter in evaluating the performance of photovoltaic (PV) solar cells is characterization of electrical response to various incident source spectra. Conventional techniques utilize monochromators that emit single band-passes across a spectral region of interest. Since many solar cells respond differently at different broadband source light levels, a white bias light source that raises the overall light level to simulate the sun's broadband emission is typically introduced. However, such sources cannot render realistic solar continua. We present some initial results demonstrating how a spectrally-dispersed broadband source modulated with Texas Instruments' Digital Light Projection (DLP®) technology can be used to more faithfully synthesize solar spectra for this application.
Securing trade lanes using an autonomous tracking device (2009)

This study describes the experience of building a highly autonomous, secure, container tracking device using commercial, off-the-shelf, hardware to optimise and secure global trade lanes. We describe the motivation for the project and the hardware and software architectures. Our approach to power conservation is discussed, including a key decision algorithm to detect the loading of a container onto an ocean-going vessel. The paper concludes with findings and insights from various field-tests.
Characterization of AES Implementations on Microprocessor-based IoT Devices (2022)

The increased proliferation of IoT devices and the emergence of 5G networks have necessitated increased security of data storage and communication in such connected devices. Thus, cryptography is used in IoT environments to provide secrecy and integrity to the data as well as both authentication and anonymity to the communications across the IoT network. However, IoT devices are resource-constrained devices; have limited memory, network bandwidth, power, and compute units. Since most of the existing cryptographic algorithms were designed to run on resource powerful devices (e.g., desktops or servers), many of these algorithms may not fit into resource-constrained devices. Therefore, in this work, we present a practical performance analysis of different implementations of the Advanced Encryption Standard (AES), which is the most widely used symmetric-key cryptosystem in the IoT environment. Specifically, we explore execution times, energy consumption, and memory usage of the different AES implementations across 4 different public libraries. Furthermore, our analysis is done using various modes, key sizes, plaintext sizes, and microprocessor-based IoT devices. Our results show that for the same combination of inputs and a given algorithm, different crypto library implementations give results with widely varying relative differences. As per the obtained results, the PyCryptodome library seems to be the most suitable one in terms of both execution time and energy on a resource-constrained IoT device and has the most efficient memory usage.
Cushioning perception is associated with both tibia acceleration peak and vibration magnitude in heel-toe running (2019)

International audience
UKF-based channel estimation and LOS/NLOS classification in UWB wireless networks (2016)

The paper addresses ultra-wideband (UWB) channel estimation and line-of-sight (LOS) vs. non-line-of-sight classification based on the  application of the unscented Kalman filter (UKF) and the analysis of the multipath channel response characteristics.  For non-linear models, the UKF provides an efficient recursive minimum mean squared error estimation technique that is successfully applied in this work, and supported by numerical results demonstrating its effectiveness in UWB multipath channel gain and time delay estimation. The multipath channel response obtained from a limited number of channel taps is subsequently characterized in terms of relevant statistical parameters including kurtosis and mean excess delay. This characterization reveals clear differences in the statistics of these parameters under LOS and NLOS propagation conditions for various channel types in residential, office, outdoor and industrial environments. Based on the estimated parameters probability density functions under LOS/NLOS conditions, a likelihood ratio test (LRT) for hypothesis classification is performed for the different UWB channel models, and numerical results show that highly reliable LOS vs. NLOS classification is achievable, with accuracy exceeding 90% for most cases of practical interest. These results can then be further exploited in enhancing the performance of positioning applications.
Comparison of Trap‐state Distribution and Carrier Transport in Nanotubular and Nanoparticulate TiO2 Electrodes for Dye‐Sensitized Solar Cells (2010)

Abstract Dye‐sensitized solar cells (DSCs) with nanotubular TiO 2 electrodes of varying thicknesses are compared to DSCs based on conventional nanoparticulate electrodes. Despite the higher degree of order in one‐dimensional nanotubular electrodes, electron transport times and diffusion coefficients, determined under short‐circuit conditions, are comparable to those of nanoparticulate electrodes. The quasi‐Fermi level, however, is much lower in the nanotubes, suggesting a lower concentration of conduction band electrons. This provides evidence for a much higher diffusion coefficient for conduction band electrons in nanotubes than in nanoparticulate films. The electron lifetime and the diffusion length are significantly longer in nanotubular TiO 2 electrodes than in nanoparticulate films. Nanotubular electrodes have a trap distribution that differs significantly from nanoparticulate electrodes; they possess relatively deeper traps and have a characteristic energy of the exponential distribution that is more than two times that of nanoparticulate electrodes.
ChemInform Abstract: Synthesis and Ion Exchange Properties of Sodium Stannosilicate: A Silver Selective Inorganic Ion Exchanger. (1990)

Abstract The title ion exchanger, synthesized by refluxing an 1:1 mixture of 0.1 M Na 2 SnO 3 ·3 H 2 O solution and 0.1 M Na 2 SiO 3 ·5 H 2 O solution for 24 h, may be described by the formula Nax(SnO2)y(SiO2)y·zH2O. The material, obtained as hard granules, is very stable at high temperatures.
Improving Handwritten Signatures Fluency via the Lognormality Principle (2020)

This chapter proposes two efficient methods to modify the fluency of dynamic signatures. The main idea is to modify the number of velocity minima or virtual target points and reconstruct the signature with the new virtual target points. If the number of virtual target points is reduced, the fluency is improved, and vice versa. The modification of the virtual target points is accomplished initially by linking the samples of an on-line signature by 8-connected Bresenham’s lines to obtain the interpolated trajectory. Then, the most perceptually important points are estimated from the corners in the trajectory. To this end, two methods are proposed. The first method, which we term resampling-wise, develops a lognormal synthetic velocity profile used for resampling the static trajectory. The second method, recovering-wise, consists in estimating the virtual target points from the perceptually important points in the trajectory, linking them by circular trajectories, and reconstructing the dynamic trajectory. Additionally, both methods can be used to generate synthetic on-line signatures from static trajectories. Both methods’ efficiency has been tested in automatic signature verification by increasing skilled forgeries’ fluidity with the proposed methods.
Uncertainties in Achieving Energy Savings from HVAC Maintenance Measures in the Field (2012)

HVAC maintenance measures in residential and small commercial buildings have been demonstrated in the laboratory to have the potential to save a significant amount of energy. This significant potential for savings has prompted utilities across the nation to include HVAC maintenance measures in energy efficiency programs. This is currently seen as the cutting edge of utility HVAC programs. However, evaluation, measurement and verification (EM&V) studies of these programs have shown mixed results. This paper presents analysis of the sources of uncertainty in delivering and measuring these programs. The gaps that can account for the discrepancy between the potential and the measured savings are described. By identifying the range of issues, program planners can address as many as possible of the potential sources of uncertainty. Measurement issues are of particular focus. An analysis is done of the uncertainties in the measurements of common variables as measured in the laboratory, by EM&V teams, by participants in maintenance programs, and by typical contractors. These uncertainties were combined to identify the resulting uncertainty in the calculated subcooling, superheat, EER values and annual kWh. The remainder of this paper presents recommendations for improving maintenance measures, based upon the uncertainties identified.
A Multiple Hydrogen-Bond Scaffold Based on Dipyrimidin-2-ylamine (2001)

A multiple hydrogen-bond array based on dipyrimidin-2-ylamine is presented, which is easily accessible. The influence of a preorganizing intramolecular hydrogen bond, tautomeric equilibria, and steric effects on the association behavior were investigated. X-ray diffraction shows that the molecules feature an ADA (acceptor-donor-acceptor) array of hydrogen-bonding sites in the solid state. The array persists in solution, and (1)H NMR titrations show that molecules with sterically nondemanding DAD arrays are selectively bound. [structure: see text]
Organocatalytic Kinetic Resolution of Propargylic Alcohols (2006)

A Lewis base catalyzed kinetic resolution of propargylic alcohols has been developed. Acylation of racemic secondary alcohols 1 in the presence of propionic anhydride and 4 mol% of chiral benzotetramisole (BTM) 2 provides enantioenriched products of type 3 and 4 with selectivity factors of up to 32. Linear and branched alkyl substrates as well as aryl precursors can be used.
Residential Community Load Management Based on Optimal Design of Standalone HRES With Model Predictive Control (2020)

Microgrids being an important entity in the distribution system, and to get their full advantages by incorporating maximum distributed generation, standalone hybrid renewable energy systems (HRESs), being environmentally-safe and economically-efficient, are considered as the promising solution to electrify remote areas where the grid power is not available. In this work, a techno-economic investigation with an optimal design of HRES is presented to fulfill the domestic electricity need for a residential area of the Sherani district in the Province of Baluchistan, Pakistan. Nine case studies based on PV/wind/diesel/battery are analyzed based on net present cost (NPC), cost of energy (COE), and emission to decide the feasible solution. HOMER tool is utilized to accomplish modeling and simulation for economic analysis and optimal sizing. Simulation results demonstrated that HRES with PV-wind-battery is the most viable option for the specified area, and the optimal sizing of components are also obtained with $ 28,620 NPC and $ 0.311/kWh COE which shows 81.65 % reduction in cost and 100 % preserving in toxic emission while fulfilling 100 % energy demand with 67.3 % of excess energy. Furthermore, MATLAB/Simulink modeling for the optimally designed system is built for technical analysis while its effectiveness is proved by keeping dc and ac buses voltage constant, safe operating range of battery state of charge (SOC) with active power balance between HRES components, as well as efficient ac voltage quality, regardless of generation disturbances and load fluctuations. The output signal has total harmonic distortion (THD) of 0.30 % as compared to 5.44 % with the conventional control scheme. The novelty lies in the sequential application of both HOMER and MATLAB simulations of the proposed HRES model and validation of the proposition for the studied area; by using and implementing model predictive control (MPC) of a reconfigurable inverter.
High performance tangential flow filtration (1997)

Conventional tangential flow filtration (TFF) has traditionally been limited to separation of solutes that differ by about ten-fold in size. Wide pore-size distributions, membrane fouling, and concentration polarization phenomena have commonly been cited as reasons for this limitation. The use of TFF in the biotechnology industry has therefore been restricted to cell-protein, virus-protein, and protein-buffer separations. A multi-disciplinary team with industrial and academic members was formed to overcome these limitations and enable protein-protein separations using High Performance TFF (HPTFF) systems. Pore-size distributions have been improved with the development of new membrane formulation and casting techniques. Membrane fouling has been controlled by operating in the transmembrane pressure-dependent regime of the filtrate flux curve and by carefully controlling fluid dynamic start-up conditions. Concentration polarization was exploited to enhance, rather than limit, the resolution of solutes. Concentration polarization has also been controlled by operating a co-current filtrate stream that maintains transmembrane pressure constant along the length of the TFF module. High yields and purification factors were obtained even with small differences in protein sieving. IgG-BSA and BSA monomer-oligomer mixtures have successfully been separated with these systems. HPTFF technology provides a competitive purification tool to complement chromatographic processing of proteins.
Solution of Sitnikov Restricted Four Body Problem When the Primaries are Point Masses or Spherical in Shape: Circular Case (2012)

In the present paper we have studied the Sitnikov problem when extended to four body problems. Here all the three primaries are moving in the circular orbit in the x-y plane and fourth particle is moving along the z-axis. First we have determined the equation of motion and then using the Lindstedt-Poincare methods and Green's function we have determined the motion of the fourth particles. Here we have find the analytical solution up to the second order. Then we have determined the time period of the motion.
Endoscopic Ultrasound-Guided Enteroenterostomy for Afferent Limb Syndrome (2020)

Afferent limb syndrome (ALS) is a rare complication of duodenopancreatectomy, resulting from the mechanical obstruction of the afferent limb usually after local malignancy recurrence. Management of ALS (ie, surgery and palliative therapy) is often unsatisfactory. We present 5 cases of endoscopic ultrasound-guided internal drainage of the afferent limb using lumen-apposing metal stents. All procedures were successful, with no related complications; 2 patients had a complete regression of their symptoms, one experienced cholangitis recurrence, and 2 patients died after some weeks because of their malignancies. Endoscopic ultrasound-guided enteroenterostomy offers a convenient and safe palliative solution for patients presenting ALS.
ICT and minibeasts: One click, one creep (2003)

Use ICT to support the teaching of a science project on minibeasts. By Dave Smith, a former primary school teacher, who is now assistant marketing director for Anglia Polytechnic University's mPowerNet ICT Training for Teachers