gebhart/patrepeval huggingface dataset:
Genotyping analysis of human papillomavirus in women in Danzhou (2013)

Objective To understand the infection of human papillomavirus (HPV) in Danzhou and the genotype distribution, and HPV infection status of the women of different ages, in order to provide a scientific basis for the prevention and treatment of HPV infection. Methods A total of 1 602 women in Danzhou were tested by HPV DNA chip technology (PCR-reverse dot blot hybridization) for 23 HPV genotypes. The infection of the subtypes was compared. Results ① HPV was detected positive in 360 cases, with the positive rate of 22.47%. The total number of the detected subtypes was 461. High-risk infection accounted for 79.39%, with the HPV genotypes of 16, 52, 58 type, and low-risk infection accounted for 20.61%, with the HPV genotypes of 43, 6 type. ② Results showed single infection in 282 cases (78.33%), multiple infection in 78 cases (21.67%). ③ The highest infection rate of women aged 40~50 (123/360, accounting for 34.17% ); ≤20 age group the highest rates of infection (7/11, accounting for 63.64%). ④ Multiple infection mostly occurred in women of 21~30 years old. Conclusion HPV genotyping can detect various subtypes at the same time, which is beneficial to early warning and early treatment of cervical cancer, and can be used as an effective method for cervical cancer screening.
Efficient quantum simulation for thermodynamics of infinite-size many-body systems in arbitrary dimensions (2019)

In this work we propose to simulate many-body thermodynamics of infinite-size quantum lattice models in one, two, and three dimensions, in terms of few-body models of only O(10) sites, which we coin as quantum entanglement simulators (QES's). The QES is described by a temperature-independent Hamiltonian, with the boundary interactions optimized by the tensor network methods to mimic the entanglement between the bulk and environment in a finite-size canonical ensemble. The reduced density matrix of the physical bulk then gives that of the infinite-size canonical ensemble under interest. We show that the QES can, for instance, accurately simulate varieties of many-body phenomena, including finite-temperature crossover and algebraic excitations of the one-dimensional spin liquid, the phase transitions and low-temperature physics of the two- and three-dimensional antiferromagnets, and the crossovers of the two-dimensional topological system. Our work provides an efficient way to explore the thermodynamics of intractable quantum many-body systems with easily accessible systems.
Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor (2012)

Several p38 MAPK inhibitors have been shown to effectively block the production of cytokines such as IL-1β, TNFα, and IL-6. Inhibitors of p38 MAP kinase therefore have significant therapeutic potential for the treatment of autoimmune disease. Compound 2a was identified as a potent TNFα production inhibitor in vitro but suffered from poor oral bioavailability. Structural modification of 2a led to the discovery of tetrahydropyrazolopyrimidine derivatives, exemplified by compound 3, with an improved pharmacokinetic profile. We found that blocking metabolism at the methyl group of the amine and constructing the tetrahydropyrimidine core were important to obtaining compounds with good biological profiles and oral bioavailability. Pursuing the structure-activity relationships of this series led to the discovery of AS1940477 (3f), with excellent cellular activity and a favorable pharmacokinetic profile. This compound represents a highly potent inhibitor of p38 MAP kinase with regard to in vivo activity in an adjuvant-induced arthritis model.
Synthesis and characterization of emulsion‐type curing agent of water‐borne epoxy resin (2013)

ABSTRACT Self‐emulsified water‐borne epoxy curing agent of nonionic type was prepared using triethylene tetramine (TETA) and derivative of epoxy resin as a capping agent, which was synthesized by liquid epoxy resin (E51) and polyethylene glycol (PEG), and the curing agent possessed emulsification and curing properties at the same time. The curing agent with good property of emulsifying liquid epoxy resin could be obtained under the condition of the molar ratio of PEG : E51 : TETA as 0.8 : 1 : 3.5 at 80°C for 5 h. The mean particle size of the emulsion liquid was about 220 nm with the prepared curing agent and epoxy resin at the mass ratio of 1 : 3. The structure of the emulsion‐type curing agent was confirmed by FTIR and 1 H NMR spectra, and the mechanism of cured film formation was also analyzed by SEM photographs. The cured film prepared by the emulsion‐type curing agent and epoxy resin under ambient cure conditions showed good properties even at high staving temperature. This study provides useful suggestions for the application of the water‐borne epoxy resins in coating industry. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2652–2659, 2013
Genetic Control of Autoantibody Production to Spermatozoa in Vasectomized Rats* (1982)

Previous studies from our laboratory using vasectomized rats of different inbred strains have suggested that MHC-linked genes do not play a major role in the formation of autoantibodies to spermatozoa. In the present paper, we demonstrate that sperm autoantibody product in is not influenced by genes in major histocompatibility complex, using vasectomized congenic rats and various crosses between high and low responder strains. We also show that autoimmune responses to spermatozoa are not influenced by genes on the Y-chromosome.
Immunotoxins in the Treatment of Hematologic Malignancies (2006)

Immunotoxins, composed of protein toxins connected to cell binding ligands including monoclonal antibodies and growth factors, have been developed for several decades to target hematologic malignancies. Protein toxins from either plants or bacteria are extremely potent based on their enzymatic inhibition of protein synthesis and induction of apoptosis. Plant toxins, particularly ricin, are useful for chemically conjugating to monoclonal antibodies, and have shown clinical activity in several types of lymphoma and leukemia. Their dose is generally limited by vascular leak syndrome. Bacterial toxins have been used to produce single chain fusions with either growth factors or recombinant antibody fragments. These agents are smaller in size (55-65 kDa) and exit the bloodstream much more rapidly than the chemical conjugates, and generally do not cause severe vascular leak syndrome. The only approved drug containing a protein toxin is denileukin diftitox, a fusion of human interleukin 2 with truncated diphtheria toxin. Denileukin diftitox has shown efficacy in cutaneous T-cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkins lymphoma. Recombinant immunotoxin BL22 is an anti-CD22 Fv fragment fused to truncated Pseudomonas exotoxin; it induces complete remissions in a high percentage of patients with chemoresistant hairy cell leukemia. The anti-CD25 recombinant immunotoxin LMB-2 is active in several CD25+ hematologic malignancies. Several other recombinant immunotoxins are undergoing preclinical development for other target antigens expressed on hematologic malignancies.
Improved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi Reaction (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTImproved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi ReactionChristopher Hulme, John Peng, Sheng-Yuh Tang, Christopher J. Burns, Isabelle Morize, and Richard LabaudiniereView Author Information Lead Discovery Department, Rhône-Poulenc Rorer Central Research, 500 Arcola Road, Collegeville, Pennsylvania 19426-0995 Cite this: J. Org. Chem. 1998, 63, 22, 8021–8023Publication Date (Web):October 1, 1998Publication History Received3 April 1998Published online1 October 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo980622rhttps://doi.org/10.1021/jo980622rbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1137Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Amines,Cyclization,Reagents,Solution phase Get e-Alerts
Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry (2007)

A conserved structural feature of human IgG molecules is the presence of an oligosaccharide moiety within the Fc region at Asn297. In addition, 15-20% of normal polyclonal IgG molecules bear N-linked oligosaccharides in the variable (V) regions of the light (L) and/or heavy (H) chains. Electrospray ionization mass spectrometry (ESI-MS) has been applied to the glycan analysis of two IgG1 myeloma proteins (Wid and Cri) after mild reduction and acidification. Heterogeneous ion peaks were observed for both the H and L chains of Wid in contrast to Cri whose L chain peak was homogeneous. Site-specific deglycosylation of the H and L chains of IgG Wid was achieved under native conditions with peptide-N-glycosidase F and endoglycosidase F2, respectively. The Fc glycoforms differed between the two proteins in that Cri-Fc bears diantennary complex-type glycans that are fully core-fucosylated and partially sialylated while Wid-Fc glycans are non-fucosylated, partially galactosylated and non-sialylated. In contrast to the Fc glycans, the L chain glycans of Wid were shown to be fucosylated, fully galactosylated and sialylated, indicating that the glycosylation machinery of the Wid-producing myeloma cells is intact. Thus, combination of the two endoglycosidases can provide a simple means of glycan analysis of both Fab and Fc by ESI-MS, which may contribute to the development of therapeutic IgG with customized glycan profiles.
Size and symmetry of the superconducting gap in the f.c.c. Cs3C60 polymorph close to the metal-Mott insulator boundary (2014)

The alkali fullerides, A(3)C(60) (A = alkali metal) are molecular superconductors that undergo a transition to a magnetic Mott-insulating state at large lattice parameters. However, although the size and the symmetry of the superconducting gap, Δ, are both crucial for the understanding of the pairing mechanism, they are currently unknown for superconducting fullerides close to the correlation-driven magnetic insulator. Here we report a comprehensive nuclear magnetic resonance (NMR) study of face-centred-cubic (f.c.c.) Cs(3)C(60) polymorph, which can be tuned continuously through the bandwidth-controlled Mott insulator-metal/superconductor transition by pressure. When superconductivity emerges from the insulating state at large interfullerene separations upon compression, we observe an isotropic (s-wave) Δ with a large gap-to-superconducting transition temperature ratio, 2Δ0/k(B)T(c) = 5.3(2) [Δ0 = Δ(0 K)]. 2Δ0/k(B)T(c) decreases continuously upon pressurization until it approaches a value of ~3.5, characteristic of weak-coupling BCS theory of superconductivity despite the dome-shaped dependence of Tc on interfullerene separation. The results indicate the importance of the electronic correlations for the pairing interaction as the metal/superconductor-insulator boundary is approached.
Geriatric nephrology and urology (1985)

Geriatric nephrology and urology , Geriatric nephrology and urology , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Hydrogen on graphene: Electronic structure, total energy, structural distortions and magnetism from first-principles calculations (2008)

Density-functional calculations of electronic structure, total energy, structural distortions, and magnetism for hydrogenated single-layer, bilayer, and multilayer graphenes are performed. It is found that hydrogen-induced magnetism can survive only at very low concentrations of hydrogen (single-atom regime) whereas hydrogen pairs with optimized structure are usually nonmagnetic. Chemisorption energy as a function of hydrogen concentration is calculated, as well as energy barriers for hydrogen binding and release. The results confirm that graphene can be perspective material for hydrogen storage. Difference between hydrogenation of graphene, nanotubes, and bulk graphite is discussed.
Characterization of serum-induced alterations in the cyclic AMP pathway in S49 lymphoma cells. (1981)

We have grown the 549 lymphoma cell line in a serum-free, chemically defined medium which contains casein, insulin, transferrin, testosterone, and linoleic acid.When grown in this medium, wild type 549 cells display a 2-3-fold increase in hormonal @-adrenergic, prostaglandin El) and nonhormonal (cholera toxin) stimulation of CAMP accumulation compared to cells grown in 10% horse serum.Wild type cells grown in serum-free medium contained 30% more 8-adrenergic receptors than did serum-grown cells, although the affinity of the receptors for [3H]dihydroalprenolo1 was unchanged.The 549 variants, UNC and kin-, failed to show the alterations in cholera toxin-or isoproterenolstimulated CAMP accumulation that were observed with wild type cells.lZ6I-labeled cholera toxin binding studies showed no change in the number or affinity of cholera toxin receptors in wild type or kin-cells grown under the two conditions.In cell homogenates, wild type cells grown in serum-containing medium had 28-45% higher activity of cyclic nucleotide phosphodiesterase than did cells grown in serum-free medium.Growth with or without serum produced no change in the K, values (14 and 0.25 p ~, respectively, for the two forms) of phosphodiesterase in these cells.Basal, NaF-, Gpp(NH)p-, and isoproterenol plus GTP-stimulated adenylate cyclase activities were similar in crude plasma membrane preparations from serum-free and serum-grown wild type cells.Horse serum contained a nondialyzable (greater than 8000 daltons), nonlipid factor which depressed the isoproterenol-stimulated CAMP accumulation of wild type 549 cells and which required 3-4 h to produce this effect.This factor appears to act via the nucleotide-coupling unit of the adenylate cyclase system and protein kinase, and ultimately results in an increase in cyclic nucleotide phosphodiesterase activity.We suggest that studies of the CAMP pathway in 549 cells should ideally be carried out under the less perturbing conditions offered by serum-free medium.The S49 lymphoma cell line provides a useful model system
Three-Dimensional Microwave Imaging: Fast and Accurate Computations with Block Resolution Algorithms (2020)

This paper considers the microwave imaging reconstruction problem, based on additive penalization and gradient-based optimization. Each evaluation of the cost function and of its gradient requires the resolution of as many high-dimensional linear systems as the number of incident fields, which represents a large amount of computations. Since all such systems involve the same matrix, we propose a block inversion strategy, based on the block-biconjugate gradient stabilized (BiCGStab) algorithm, with efficient implementations specific to the microwave imaging context. Numerical experiments performed on synthetic data and on real measurements show that savings in computing time can reach a factor of two compared to the standard, sequential, BiCGStab implementation. Improvements brought by the block approach are even more important for the most difficult reconstruction problems, that is, with high-frequency illuminations and/or highly contrasted objects. The proposed reconstruction strategy is shown to achieve satisfactory estimates for objects of the Fresnel database, even on the most contrasted ones.
Styrning av råvarulager och förbättrat materialflöde (2004)

Detta examensarbete är utfört vid Ahlstrom Cores AB som tillverkar spirallindade pappershylsor vid tre anläggningar i Sverige. Pappershylsor används främst vid tillverkning av papper av olika kvalitéer och företagets kunder använder då hylsorna till att linda upp det färdiga pappret på. Råvaror vid tillverkningen är hylskartong av olika kvalitéer och bredder samt lim. Rapporten behandlar två separata uppgifter. Den första och större av de två är att utforma ett nytt system för styrning av råvarulager och den andra är att förbättra materialflödet vid en av företagets anläggningar. I dagsläget saknar företaget regler för när och i vilka mängder råmaterial ska köpas in. Detta föranleder företaget att tro att man skulle kunna minska sina lager utan att för den skull minska sin servicegrad. Samtliga slutprodukter produceras efter ett recept som specificerar hur en slutprodukt byggs upp. Rapporten visar hur företaget utifrån ett givet produktionsschema och samlingen av recept kan beräkna sitt materialbehov för den kommande tidsperioden. Rapporten drar också slutsatsen att företaget bör använda partiformningsmetoden Lot-for-lot för samtliga sina råmaterial utom två. Att dessa två råmaterial inte kan styras på samma sätt som de övriga beror på att dessa materials förbrukning varierar mycket mot den som beskrivs i recepten. För de två materialen rekommenderas att beställningspunktsystem används för den ena och återfyllnadsnivå för den andra. En beräkning visar att det nya lagerstyrningssystemet kommer att minska företagets råvarulagrer med cirka 45 %. För materialflödesproblemet vid en av anläggningarna ger rapporten ett antal åtgärdsförslag som samtliga har det gemensamt att inga större investeringar kommer att krävas för att genomföra dem. Bland dessa åtgärdsförslag kan nämnas en ny disposition av företagets råvaru- och färdigvarulager. Denna nya disposition syftar till att minska längden på de interna materialtransporterna. Rapporten ger också ett förslag på hur råvarulagren ska organiseras och rekommenderar att en större maskin flyttas inom anläggningen. Detta genomförs framförallt för att bättre kunna utnyttja en yta som idag knappt används, samtidigt som denna maskin med dagens placering tar upp mer plats än vad som kan anses nödvändigt. Övergripande för åtgärderna vid anläggningen är att ingen exakt bedömning av hur stor förbättring åtgärderna innebär har gjorts, utan rapporten nöjer sig med att konstatera att det blir bättre.
Automated Ad Hoc Networking for Mobile and Hybrid Music Performance. (2011)

Zero-configuration networking is a helpful device to mitigate numerous problems of manual configuration of connections of network connection in performance. We discuss how this technique can be used to create a networked name-space. This helps organize networked music performance making them robust and easy to set up and use. Participatory networking which scales becomes easy to achieve and explicit addressing is made unnecessary.
Studies on Comb-like Polymers. 2. Poly(octadecylethylene oxide) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Comb-like Polymers. 2. Poly(octadecylethylene oxide)F. Andruzzi, D. Lupinacci, and P. L. MagagniniCite this: Macromolecules 1980, 13, 1, 15–18Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ma60073a003https://doi.org/10.1021/ma60073a003research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of Initial Shear Strength on Time-to-Failure of Copper (Cu) Wire Bonds in Thermal Aging Condition (2018)

Abstract Copper (Cu) wire bond is used in a majority of microelectronic devices but has not been fully accepted by all industries due to potential reliability issues. Good quality bond is believed to provide high reliability. Shear strength and intermetallic (IMC) coverage are being used as indicators, however there is no developed model. High shear strength is a result of large IMC coverage laterally under the ball, but the reliability of the bond is also related to IMC longitudinal growth (thickness). This work involves studying effect of shear strength on reliability of a variety of experimental Cu ball bonds by performing temperature aging experiments on test devices, in QFN packages. The ball bonds are made by altering ultrasonic power and time to obtain different IMC coverage. All test packages are monitored for resistance change at specific intervals by performing four point resistance measurement. Resistance increase is analyzed with initial shear strength to determine whether “good quality” bonds always lead to high reliability.
Rules based voltage control for distribution networks combined with TSO- DSO reactive power exchanges limitations (2015)

This article deals with the evolution of voltage and reactive power control strategies in distribution networks with distributed generation. First a comprehensive review of voltage control and reactive power management techniques is given. The gap between actual or short-term industrial possibilities of distribution grids and techniques proposed in literature is highlighted. A realistic control based on local rules using the reactive power capabilities of distributed generators, capacitor banks and on load tap changer (OLTC) voltage setpoint is then presented. Its objective is to control both distribution network voltages and reactive power flows at the Transport System Operator (TSO) - Distribution System Operator (DSO) interface. The proposed control allows limiting OLTC bounds and conflicts between local rules. At last, this paper presents simulations results based on French MV distribution network in order to depict the efficiency of such a control.