gebhart/patrepeval huggingface dataset:
Rheology of the Human Sclera (1965)

Research Articles| March 24 2010 Rheology of the Human Sclera: Unifying Formulation of Ocular Rigidity Subject Area: Ophthalmology W.K. McEwen; W.K. McEwen From the Francis I. Proctor Foundation, University of California, San Francisco Medical School, San Francisco, California Search for other works by this author on: This Site PubMed Google Scholar Roger St. Helen Roger St. Helen From the Francis I. Proctor Foundation, University of California, San Francisco Medical School, San Francisco, California Search for other works by this author on: This Site PubMed Google Scholar Ophthalmologica (1965) 150 (5): 321–346. https://doi.org/10.1159/000304862 Article history Published Online: March 24 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation W.K. McEwen, Roger St. Helen; Rheology of the Human Sclera: Unifying Formulation of Ocular Rigidity. Ophthalmologica 1 May 1965; 150 (5): 321–346. https://doi.org/10.1159/000304862 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsOphthalmologica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Characterization of a Mycobacterium tuberculosis insertion sequence, IS6110, and its application in diagnosis (1990)

An insertion sequence-like element, IS6110, was isolated from a Mycobacterium tuberculosis cosmid library as a repetitive sequence. IS6110 shows similarities with elements of the IS3 family. This insertion sequence was found to be specific to mycobacteria belonging to the M. tuberculosis complex. For detection and identification of M. tuberculosis bacilli in uncultured specimens, oligonucleotides derived from the IS6110 sequence were used as primers and probes in polymerase chain reaction studies. The results obtained were consistent with results of classical identification procedures, bacteriological data, and clinical criteria.
Interactive Cohort Identification of Sleep Disorder Patients Using Natural Language Processing and i2b2 (2015)

Natural language processing was shown to be powerful for quickly converting large amount of semi-structured or unstructured clinical data into discrete concepts, which in combination of intuitive domain specific ontologies, allows fast and effective interactive cohort identification through the i2b2 platform for research and clinical use.
UV Curable Thiol-Ene Adhesive for Flexible Packaging Based on CO (2014)

An important thiol ester photosensitive monomer COMP (CO-based mercaptopropionate) was prepared via melt polycondensation method using castor oil (CO) and 3-Mercaptopropionic acid (3-MPA). Structure of the thiol-compounds was characterized by FT-IR, 1H-NMR. When the thiol compound was used as photosensitive monomer and polyurethane-acrylate prepolymer was used as main material in UV curable adhesive. The UV curable adhesive showed good curing behaviors and thermal stability with curing time 100s, T-peel strength 3.8N/25mm and shrinkage rate 8%; so the UV curable adhesive could meet the requirements for flexible packaging composite.
Vitamin C measurement in critical illness: challenges, methodologies and quality improvements (2019)

Background There is renewed interest in high-dose vitamin C interventions in clinical medicine due to its antioxidant properties, safe use and cost-effectiveness. Yet, randomised control trials (RCTs) employing these interventions are failing to include robust analytical methodology and proper sample handling and processing techniques. Consequently, comparisons between studies becomes impossible as there is no metrological traceability and results may be prone to pre-analytical errors. Content Through published vitamin C stability studies, method comparison papers and data from vitamin C external quality assurance programs, an assessment was made on the functionality of current methods for critically ill patient samples. Summary Data was obtained from two external quality assurance programs, two papers assessing sample stability and interlaboratory agreement and a publication on vitamin C method comparisons. A shift from spectrophotometric and enzymatic methodologies to high performance liquid chromatography (HPLC) greatly improved the variability and interlaboratory agreement. Therefore, the current analytical performance of vitamin C HPLC methodologies are acceptable for the requirements of a high-dose vitamin C RCTs. Outlook Recommendations across the total testing process of vitamin C have been provided to improve the quality of the results. The harmonisation of sample handling and processing procedures will further improve the reliability of current analytical methodologies.
Recherche d’une rôle physiologique pour la protéine prion cellulaire (PrPc) (2004)

De nombreuses études sont menées pour élucider le mécanisme de la transformation de la protéine prion normale (PrPc) en protéine pathogène résistante aux protéases (PrPres) et pour comprendre comment l’accumulation de cette PrPres peut induire les dégénérescences nerveuses observées lors des Encéphalopathies Spongiformes Transmissibles (EST). Cependant, la protéine prion est une protéine ubiquitaire présente dans de nombreux tissus autres que le tissu nerveux et le rôle cellulaire «normal» joué par cette PrPc est très controversé et reste encore une énigme. Différentes équipes INRA utilisent leurs compétences en physiologie pour établir la présence et les voies de sécrétions de la protéine prion normale dans différents organes. Ces études se font en utilisant des modèles animaux et cellulaires classiques, mais aussi des souris où le gène codant pour la protéine prion est supprimé (PrP-/-) ou sa quantité sur-exprimée par introduction de multiples copies de ce gène. Ceci permettra d’une part d’étudier le ou les rôles possibles de cette protéine dans les différents tissus et fluides biologiques (protection contre le stress oxydatif, transport de métaux, signalisation cellulaire, etc.), d’autre part de rechercher si lors de l’infection, de la protéine prion pathogène est retrouvée dans certains de ces fluides biologiques tels que le lait et le sperme. En effet, si les études passées n’ont jamais montré de protéine prion pathogène dans ces fluides, des travaux utilisant des méthodes plus sensibles sont nécessaires pour confirmer ces résultats.
A Comparative Analysis of the Biomechanics and Biochemistry of Cell-Derived and Cell-Remodeled Matrices: Implications for Wound Healing and Regenerative Medicine (2004)

The purpose of this research was to study the synthesis and remodeling of extracellular matrix (ECM) by fibroblasts with special emphasis on the culture environment (media composition and initial ECM composition) and the resulting mechanical integrity of the ECM. This was investigated by culturing fibroblasts for 3 weeks in a variety of culture conditions consisting of collagen gels, fibrin gels, or media permissive to the self-production of ECM (Cell-Derived Matrix), and quantifying the mechanics of the resulting ECM. The mechanical characteristics were related to the biochemistry of the resulting ECM, notably in terms of collagen accumulation and collagen fibril diameters. The ultimate tensile strength (UTS) of the collagen gels and fibrin gels at the end of the 3-week period was 168.5 ± 43.1 kPa and 133.2 ± 10.6 kPa, respectively. The ultimate tensile strength of the cell-derived matrices was 223.2 ± 9 kPa, and up to 697.1 ± 36.1 kPa when cultured in a chemically-defined medium that was developed for the rapid growth of matrix in a more defined environment. Normalizing the strength to collagen density resulted in a UTS / Collagen Density in these groups of 6.4 ± 1.9 kPa/mg/cm3, 25.9 ± 2.4 kPa/mg/cm3, 14.5 ± 1.1 kPa/mg/cm3, and 40.0 ± 1.9 kPa/mg/cm3, respectively. Cells were synthetically more active when they produced their own matrix than when they were placed within gels. The resulting matrix was also significantly stronger when it was self-produced than when the cells rearranged the matrix within gels that corresponded to a significantly larger fraction of non-acid and pepsin extractable collagen. These studies indicate that cell-derived matrices have potential both as in vitro wound healing models and as soft connective tissue substitutes.
Biosynthesis of Cypridina Luciferin in Cypridina noctiluca (2007)

Luminescence in the marine ostracods Cypridina noctiluca and Vargula hilgendorfii is produced by Cypridina luciferin-luciferase reaction.In this study, a feeding experiment with stable isotope-labeled amino acids was performed in C. noctiluca.The results of LC/ESI-MS analyses indicated that C. noctiluca is able to synthesize Cypridina luciferin de novo from three amino acids (L-tryptophan, L-isoleucine, and L-arginine).Luminescence in living animals is produced principally through luciferin-luciferase reaction. 1In marine organisms, the chemical structures of several luciferins have been determined, including coelenterazine, 2 Watasenia luciferin, 3 Cypridina luciferin, 4 krill luciferin, 5 and dinoflagellate luciferin. 6The well-characterized luciferins are imidazopyrazinone (3,7-dihydroimidazopyrazin-3-one) compounds such as coelenterazine and Cypridina luciferin, and they are distributed in various marine animals. 1,7,8,9minous ostracods have been found in the genera of Vargula, Cypridina, Pyrocypris and Conchoecia. 1,10,11Vargula, Cypridina and Pyrocypris are classified in the family Cypridinidae and the luciferin for luciferase reaction is Cypridina luciferin. 10Conchoecia is classified in the family Halocyprididae and the luciferin for luciferase reaction is coelenterazine. 8,9,12As previously proposed, 4,13 imidazopyrazinone-type luciferins would be biosynthesized from three amino acids (i.e., arginine, isoleucine and tryptophan for Cypridina luciferin; phenylalanine and two tyrosines for coelenterazine).[16] However, the biosynthesis of Cypridina luciferin in other species such as Cypridina and Pyrocypris has
Improved Maximum Power Point Tracking for Solar PV Module using ANFIS (2013)

The output power delivered by solar photovoltaic (PV) module depends on weather conditions and to obtain maximum they are required to operate at maximum available power point for different weather conditions. Maximum power point tracking (MPPT) controllers are usually employed in PV power systems to extract maximum power. Since the solar PV module characteristics are highly nonlinear, conventional control techniques could be inefficient for an optimal use of these systems. This paper presents an improved methodology for maximum power point tracking of a solar PV module using adaptive neuro fuzzy inference system (ANFIS). Mathematical modeling of a solar PV module has been done in sequential steps using Matlab/Simulink software package and ANFIS based maximum power point tracking scheme is developed to control the extraction of maximum power from this solar PV module. The proposed ANFIS based reference model is trained to generate maximum power corresponding to varying solar irradiance level and operating temperature. Simulation results reveals that the response of proposed ANFIS based MPPT method is more accurate and fast as compared to the conventional techniques like perturb & observation (P&O). The main advantage of proposed MPPT scheme is fast response and high gain even at lower value of solar irradiance level without oscillations near the point of maximum power. The analytical and simulation results of this research are presented to validate the concept.
Integrated RF Silicon Photonics from High Power Photodiodes to Linear Modulators (2014)

Many photonic implementations of analog and radio-frequency transmission require a high degree of uncorrupted dynamic range. We present experimental results and discuss the dynamic range of CMOS compatible high power photodiodes and modulators.
Heredity in Febrile Convulsions: Is It HLA-Dependent? (1987)

One hundred children consecutively treated for simple febrile convulsions (FC) were investigated with respect to hereditary factors. Twenty-five of the children had parents or siblings with FC. HLA-typing was performed in all available members of ten families with one or two FC children and one FC parent, and in one family with two FC children but no FC parent. There was no clear association with a particular HLA haplotype in any of these families.
A Dynamic System Model for Estimating Surface-Induced Frame Loads During Off-Road Cycling (1994)

To facilitate the design analysis of off-road bicycle frames, this paper reports a dynamic model of the bicycle/rider system which estimates frame loads for bicycles traveling over rough surfaces. To develop this model, the frame loads at rider contact points were first measured experimentally as a rider coasted over a test track with randomly spaced surface irregularities in both seated and standing positions. Following this measurement, a dynamic system model was developed with the aid of the commercial software package, Dynamic Analysis and Design Software (DADS). The development process consisted of two stages. The first stage involved developing component models (e.g., seat) which could reproduce the essentials of the measured data. The second stage involved identification of parameter values for those parameters shown to most profoundly affect simulated load results. Following parameter identification, simulated loads were statistically tested and were not significantly different from experimental loads. Also, maximum magnitude dynamic loads were compared to corresponding static load magnitudes and were larger for eight of the ten load components measured. With the importance of dynamic loads demonstrated and the model verified, it can now be used advantageously to generate a loading database for design analysis purposes.
Making Sure That Hydrofluorocarbons Are “Ozone Friendly” (1996)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMaking Sure That Hydrofluorocarbons Are "Ozone Friendly"Joseph S. Francisco and M. Matti MaricqView Author Information Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 Research Laboratory, Ford Motor Company, P.O. Box 2053, MD 3083, Dearborn, Michigan 48121Cite this: Acc. Chem. Res. 1996, 29, 8, 391–397Publication Date (Web):August 13, 1996Publication History Received2 February 1996Published online13 August 1996Published inissue 13 August 1996https://pubs.acs.org/doi/10.1021/ar950114thttps://doi.org/10.1021/ar950114tresearch-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views437Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical reactions,Degradation,Fluorine,Kinetic parameters,Organic compounds Get e-Alerts
Theory of Disagreement-Based Active Learning (2014)

Active learning is a protocol for supervised machine learning, in which a learning algorithm sequentially requests the labels of selected data points from a large pool of unlabeled data. This contrasts with passive learning, where the labeled data are taken at random. The objective in active learning is to produce a highly-accurate classifier, ideally using fewer labels than the number of random labeled data sufficient for passive learning to achieve the same. This article describes recent advances in our understanding of the theoretical benefits of active learning, and implications for the design of effective active learning algorithms. Much of the article focuses on a particular technique, namely disagreementbased active learning, which by now has amassed a mature and coherent literature. It also briefly surveys several alternative approaches from the literature. The emphasis is on theorems regarding the performance of a few general algorithms, including rigorous proofs where appropriate. However, the presentation is intended to be pedagogical, focusing on results that illustrate fundamental ideas, rather than obtaining the strongest or most general known theorems. The intended audience includes researchers and advanced graduate students in machine learning and statistics, interested in gaining a deeper understanding of the recent and ongoing developments in the theory of active learning.
Calculation of 13C NMR chemical shifts for aromatic carbons in polyalkylated benzenes (1984)

Abstract 13 C NMR spectra of a large number of polyalkylated benzenes with branched and linear aliphatic chains have been studied. This resulted in the development of a general procedure that can be used for the calculation of the aromatic chemical shifts in any polyalkylated benzene.
Heat Transfer near Sharp and Blunt Fins Protruded in a Supersonic Flow (2007)

Heat transfer characteristic near a sharp fin and blunt fin were studied in a supersonic flow. The unit Reynolds number was 5x10/m, respectively. Infra-red thermography was used to obtain the variation of surface heat transfer coefficient distribution. The oil and lampblack method was conducted to understand flow fields near a fin. Heat transfer increase in a flow separation region and peak heating appears at a flow reattachment region. As the wedge angle increases, effective area and peak value also increased.
Democratisation and the environment: NGOs and deforestation policies in India (Karnataka) and Indonesia (North Sumatra) (1996)

(1996). Democratisation and the environment: NGOs and deforestation policies in India (Karnataka) and Indonesia (North Sumatra) The Journal of Commonwealth & Comparative Politics: Vol. 34, NGOs and Environmental Policies: Asia and Africa, pp. 9-37.
Stereoelectronic Factors That Influence Kinetic and Thermodynamic Sites of Protonation of (η6-Arene)molybdenum(phosphine)3Complexes (1999)

We have previously reported (J. Am. Chem. Soc. 1995, 117, 12639) the arene complex (η6-C6H6)Mo(TRIPOD) (1), where TRIPOD = 1,1,1-tris(diphenylphosphinomethyl)ethane, is protonated upon addition of 1 equiv of D+ to yield the metal−hydride [(η6-C6H5D)Mo(TRIPOD)H]+ (1H+-d1) via exo addition of D+ to the arene ligand followed by migration to the metal of the endo proton of the putative η5-cyclohexadienyl complex [(η5-C6H6D)Mo(TRIPOD)]+ (1‡). The opposite isotopomer is obtained when (η6-C6D6)Mo(TRIPOD) (1-d6) is employed to give [(η6-C6D5H)Mo(TRIPOD)D]+ (1D+-d6). Our recent investigation of the electronic structure of 1 and its one-electron oxidized derivative [(η6-C6H6)Mo(TRIPOD)]+ (1+) suggested the mechanism of protonation is not driven entirely by electronic factors; steric factors are likely important for indirect protonation of 1. Consistent with that conclusion, we report herein that some other phosphine derivatives are protonated directly at the metal center. Thus, under the same reaction conditions the monodentate phosphine derivatives (η6-C6D6)Mo(PR3)3, where PR3 = PPh2Me (3-d6), PPhMe2 (4-d6), and PMe3 (5-d6), are protonated directly at the metal 0%, 20%, and 40% of the time, respectively. The remainder of the protonations take place via the aforementioned indirect protonation of the arene ligand. Surprisingly, (η6-C6D6)Mo(TRIPHOS) (2-d6), where TRIPHOS = bis(2-diphenylphosphinoethyl)phenylphosphine, reacts with H+ by direct protonation of the metal center 80% of the time to give a C1-symmetric kinetic hydride [(η6-C6D6)Mo(TRIPHOS)H]+ (2KH+-d6). The other 20% of the time 2-d6 reacts via the arene mechanism to give [(η6-C6D5H)Mo(TRIPHOS)D]+ (2KD+-d6). The two enantiomeric forms of 2KH+are observed to be in rapid equilibrium (k = 6.4 × 103 s-1 at −87 °C). Compound 2KH+eventually isomerizes (k = 6.1 × 10-4 s-1 at −60 °C) to the Cs-symmetric thermodynamic hydride [(η6-C6H6)Mo(TRIPHOS)H]+ (2TH+). We conclude from the crystal structures of 1−4, tracer studies, and electronic structure calculations of the five derivatives 1−5 presented herein that indirect protonation does not represent a general mechanism for this class of compounds. In addition to electronic factors that favor direct protonation of the metal center from an equatorial trajectory, subtle steric demands of the phosphine ligands play an important role in dictating whether a proton initially attacks the arene ligand or the metal of 1−5. The semiempirical PM3(tm) method may be used to map metal-based frontier orbitals of the complexes 1−5 onto plots of their surface electron densities, thereby revealing sterically accessible metal electron density. Such plots provide straightforward models that predict the mechanisms of protonation.