gebhart/patrepeval huggingface dataset:
Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia (1999)

Primitive subsets of leukemic cells isolated by using fluorescence-activated cell sorting from patients with newly diagnosed Ph(+)/BCR-ABL(+) chronic myeloid leukemia display an abnormal ability to proliferate in vitro in the absence of added growth factors. We now show from analyses of growth-factor gene expression, protein production, and antibody inhibition studies that this deregulated growth can be explained, at least in part, by a novel differentiation-controlled autocrine mechanism. This mechanism involves the consistent and selective activation of IL-3 and granulocyte colony-stimulating factor (G-CSF) production and a stimulation of STAT5 phosphorylation in CD34(+) leukemic cells. When these cells differentiate into CD34(-) cells in vivo, IL-3 and G-CSF production declines, and the cells concomitantly lose their capacity for autonomous growth in vitro despite their continued expression of BCR-ABL. Based on previous studies of normal cells, excessive exposure of the most primitive chronic myeloid leukemia cells to IL-3 and G-CSF through an autocrine mechanism could explain their paradoxically decreased self-renewal in vitro and slow accumulation in vivo, in spite of an increased cycling activity and selective expansion of later compartments.
Long-Term Results of Surgical Subxiphoid Pericardial Drainage (1997)

A series of 64 consecutive patients who underwent surgical subxiphoid drainage of pericardial effusion over an 11-year period, was analysed both for recurrence of pericardial pathology and survival. The mean follow-up time was 4 years (6 months to 10 years). Twelve patients had recurrent effusion (18%), all except one within 6 months: six patients (9%) had another drainage procedure which was the definitive treatment except in one terminal cancer patient with intractable malignant effusion who died of cardiac tamponade. The remaining six recurrent effusions could be treated conservatively. One patient with idiopathic effusion developed late constrictive pericarditis. Patients with underlying malignancy (n = 26) had significantly worse actuarial survival than the others (actuarial survival at 1 and 5 years of 51% and 0% vs 87% and 76%, respectively). However, their probability of remaining free of recurrence did not differ significantly (actuarial freedom at 1 year of 89% vs 76%). In conclusion, subxiphoid drainage provides a simple, safe and expeditious treatment of most symptomatic pericardial effusions with one in ten patients requiring a repeat drainage for recurrence. In particular, it offers a good palliation in most patients with underlying neoplastic disease. Routine echocardiography is recommended at one and six months to catch most of the recurrent effusions.
Translating a gene expression signature for multiple myeloma prognosis into a robust high-throughput assay for clinical use (2014)

The 70-gene assay, commercialized under the name 'MyPRS®' (Myeloma Prognostic Risk Score) and performed in Signal Genetics' CLIA-certified high throughput flow-cytometry and molecular profiling laboratory is a reproducible and standardized method of multiple myeloma prognostication.
Abstract 2896: Nanoparticle co-delivery of RNAi and chemotherapy for the treatment of drug-resistant cancers (2012)

Abstract The emergence of drug resistance has been a critical barrier for effective cancer chemotherapy. Recently, RNA interference (RNAi) has shown promise in suppressing the over-expression of drug resistance-associated proteins such as P-glycoprotein and Prohibitin1, and in treating multidrug resistant cancers through combination with chemotherapy. Nevertheless, the safe and effective delivery of RNAi therapeutics (e.g., siRNA and miRNA) to target cells remains a major hurdle for their clinical applications, and the co-delivery of RNAi and chemotherapeutic agents in a controlled fashion requires specific delivery vehicles. Herein, we present a novel nanoparticle (NP) platform to tackle the challenges associated with the delivery of siRNA and chemotherapeutic drugs, using biodegradable and biocompatible polymers and lipids. The hybrid lipid-polymer NP has a differentially charged hollow core/shell nanostructure which provides the delivery system with three distinct functional features: (i) a positively charged inner hollow core for dense loading of siRNA; (ii) a middle hydrophobic polymer layer for the encapsulation of anti-cancer drugs (e.g., taxanes) and for the controlled release of both siRNA and drug; and (iii) a relatively neutral lipid-polyethylene glycol (PEG) surface to keep the NP stable and prolong its systematic circulation. Moreover, such hybrid NPs can be formulated in a simple and robust way that could facilitate future scale-up. By screening various factors, such as inner cationic lipids, outer PEG chain length, and formulation parameters, the hybrid lipid-polymer NPs show excellent in vitro knockdown efficacy at low doses of siRNA, with greater than 80% luciferase silencing at an siRNA dose of 0.4 pmol (4.0 nM) and ∼ 95% silencing at a dose of 2.0 pmol (20 nM). These NPs can also efficiently reduce the expression of drug resistance-associated proteins (e.g., MDR1 and Prohibitin1), as evidenced by qPCR. Cellular cytotoxicity experiments further confirm that this NP co-delivery strategy can drastically improve the sensitivity of drug-resistant cells to chemotherapy. In addition, these hybrid NPs demonstrate promising in vivo results for co-delivering siRNA and chemotherapeutic drugs to treat drug-resistant cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2896. doi:1538-7445.AM2012-2896
Probing the Vanadyl and Molybdenyl Bonds in Complex Vanadomolybdate Structures (2005)

A solid solution was found to exist in the quaternary Li(2)O-MgO-V(2)O(5)-MoO(3) system between the two phases Mg(2.5)VMoO(8) and Li(2)Mg(2)(MoO(4))(3). Both Mg(2.5)VMoO(8) and Li(2)Mg(2)(MoO(4))(3) are isostructural with the mineral lyonsite, and substitution according to the formula square(1/4-x/6)Li(4x/3)Mg(15/4-7x/6)V(3/2-x)Mo(3/2+x)O(12) (0 < or = x < or = 1.5, where square denotes a cation vacancy) demonstrates that a complete solid solution exits coupling the addition of molybdenum and lithium with the subtraction of cation vacancies, magnesium, and vanadium and vice versa. Vibrational Raman spectroscopy indicates that molybdenum-oxo double bonds preferentially associate with the cation vacancies.
Statistically Analyzed Photoresponse of Elastically Bent CdS Nanowires Probed by Light-Compatible In Situ High-Resolution TEM (2016)

We demonstrate that high resolution transmission electron microscopy (HRTEM) paired with light illumination of a sample and its electrical probing can be utilized for the in situ study of initiated photocurrents in free-standing nanowires. Morphology, phase and crystallographic information from numerous individual CdS nanowires is obtained simultaneously with photocurrent measurements. Our results indicate that elastically bent CdS nanowires possessing a wurtzite structure show statistically unchanged values of ON/OFF (photocurrent/dark current) ratios. Photocurrent spectroscopy reveals red shifts of several nanometers in the cutoff wavelength after nanowire bending. This results from deformation-induced lattice strain and associated changes in the nanowire band structure, as confirmed by selected area electron diffraction (SAED) analyses and density functional tight binding (DFTB) simulations. The ON/OFF ratio stabilities and photocurrent spectroscopy shift of bent CdS nanowires are important clues for future flexible electronics, optoelectronics, and photovoltaics.
P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements (2013)

The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. Also PRODH2, which degrades 4-hydroxy-L-proline, a product of protein (e.g. collagen) catabolism, was recently described as a p53 target. Here, we confirmed p53-dependent induction of endogenous PRODH in response to genotoxic damage in cell lines of different histological origin. We established that over-expression of TAp73β or TAp63β is sufficient to induce PRODH expression in p53-null cells and that PRODH expression parallels the modulation of endogenous p73 by genotoxic drugs in several cell lines. The p53, p63, and p73-dependent transcriptional activation was linked to specific intronic response elements (REs), among those predicted by bioinformatics tools and experimentally validated by a yeast-based transactivation assay. p53 occupancy measurements were validated in HCT116 and MCF7 human cell lines. Conversely, PRODH2 was not responsive to p63 nor p73 and, at best, could be considered a weak p53 target. In fact, minimal levels of PRODH2 transcript induction by genotoxic stress was observed exclusively in one of four p53 wild-type cell lines tested. Consistently, all predicted p53 REs in PRODH2 were poor matches to the p53 RE consensus and showed very weak responsiveness, only to p53, in the functional assay. Taken together, our results highlight that PRODH, but not PRODH2, expression is under the control of p53 family members, specifically p53 and p73. This supports a deeper link between proteins of the p53-family and metabolic pathways, as PRODH modulates the balance of proline and glutamate levels and those of their derivative alpha-keto-glutarate (α-KG) under normal and pathological (tumor) conditions.
Nondestructive readout mode static induction transistor (SIT) photo sensors (1993)

The nondestructive readout (NDRO) performance of two static induction transistor (SIT) photosensors, a 40*40 pixel area array and a 140-b linear array, is examined. NDRO operation in the SIT sensors is demonstrated by imaging with the area array and by examining the output waveform of the linear array. The charge lost per NDRO cycle in the linear array was 0.014% near the saturation signal level, and no charge loss could be detected at the <or=0.5 saturation level. NDRO performance in the area array was degraded compared to the linear array, due to the larger value of the load capacitance connected to the output electrode of the SIT. NDRO operation also enables the cancellation of both the photosite reset noise and the signal nonuniformity by subtracting the first NDRO output from the following NDRO outputs, as well as the advantage of monitoring the signal state during the integration period.<<ETX>>
Comparison of Survival Rate between Posterior-Stabilized and Constrained Condylar Articulations in Revision Total Knee Arthroplasty: A Minimum 5-Year Follow-up Analysis (2022)

In RTKA, both PS and CCK showed similar survival rates and clinical outcomes at a mean follow-up of 9.2 years. Implant articulation did not affect the outcomes when properly indicated.
Moving the Needle: Promoting the Research, Dissemination, and Implementation of Oncology Acupuncture (2020)

MSKCC) that just celebrated two decades of leadership in the integrative oncology space. (Mao is also a past president of the Society for Integrative Oncology.) Mao and Liou first provide a brief review of the advances in research and uptake of acupuncture in oncology programs while identifying some present challenges related to dissemination and implementation-themes that were central to the robust SAR conference. The authors then invite readers to participate in a SAR-backed symposium April 24-25, 2020 at MSKCC that is meant to address some of the core issues facing clinicians, scientists, and policy leaders active in the field today. This column and the event are linked to SAR's commitment, through a grant from the quasi-public Patient-Centered Outcomes Research Institute (PCORI), to develop and advance an action plan for dissemination and implementation to reflect the advancing oncology acupuncture science.
alpha 1-Receptor localization in rat heart and kidney using autoradiography (1985)

To study the distribution of alpha 1-adrenergic receptors in rat heart, kidney, and skeletal muscle, we used light-microscopic autoradiography of [3H]prazosin. Scintillation spectrometry of frozen sections demonstrated rapid binding, saturability, stereospecificity, and agonist and antagonist binding characteristic of an alpha-receptor. For autoradiography, sections were incubated, processed, and grain density quantified using a computer-based image analyzer. Specific alpha 1-receptor binding was found over cardiac myocytes in the left and right ventricles but not over skeletal muscle. Scatchard analyses of specific grain densities over cardiac myocytes gave a dissociation constant (Kd) of 0.55 +/- 0.18 nM (SD, n = 4 rats) and a maximum number of binding sites (Bmax) of 448 +/- 90 grains/10(-2) mm2. Renal arterioles had a higher specific grain density than myocardial arterioles at all concentrations of [3H]prazosin (P less than 0.001). Scatchard analyses showed that renal arterioles had a Kd of 0.27 nM and a Bmax of 1,259 grains/10(-2) mm2, whereas myocardial arterioles had a Kd of 1.64 nM and a Bmax of 183 grains/10(-2) mm2. Arterioles in the flexor carpi radialis muscle were not labeled. Renal cortex tubules had the highest grain density of any structure studied, i.e., higher than grain density over glomeruli or tubules in the renal medulla. These observations indicate that significant differences exist in the distribution and affinity of alpha 1-adrenergic receptors in various vascular beds and parenchymal tissues.
Optical Observation of Thermal Disturbance and Quench Occurring in Immersion-Cooled Superconductors in Liquid Helium. (1994)

The present authors have succeeded in optical observation on thermal disturbance, quench zone, and its rapid propagation in a superconducting coil, immersion-cooled in liquid helium, by producing the respective dark zones corresponding to them on its illuminated surface. The thermal disturbance to the test coil was applied by pulse-heating of film heaters wound in it. Transient behavior of the dark zones under various conditions of pulse heating and transport current was recorded with a high-speed video system, and compared with the measured time histories of tap voltages and temperatures at various locations of the test coil; the agreement was very good.
ChemInform Abstract: Preparation of Indoles and Oxindoles from N‐(tert‐Butoxycarbonyl)‐2‐ alkylanilines. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nitro‐Mannich Reaction (2013)

Abstract Review: 274 refs.
Mini Focus: Interview With Dr James Birchall (2012)

James Birchall is a Reader in Pharmaceutics at the School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Dr Birchall graduated from Bath University in 1993 and completed his PhD researching drug and DNA delivery systems in 1998 (Cardiff University). His current research is focussed on the use of microneedles for cutaneous drug, vaccine and gene delivery, and the exploitation of novel dry powder and metered dose inhaler formulations for pulmonary drug and gene delivery. Dr Birchall has acted as Associate Editor of Critical Reviews in Therapeutic Drug Carrier Systems, is a member of the Editorial Board of Expert Review of Medical Devices and is an Honorary Senior Lecturer and Research Pharmacist with the National Health Service. His research is funded by the NIH, Royal Society, British Skin Foundation and 3M Healthcare Ltd. Dr Birchall speaks to Laura Harvey (Commissioning Editor) on some of the challenges and future directions of transdermal delivery research into gene delivery and microneedle technology today.
Certain surfactants show promise in the therapy of pulmonary tuberculosis. (2011)

The studies presented here establish that certain surfactants are proficient in removing MTB's shield and, because they are well known as cell permeabilizing agents, they may also enhance the effectiveness of antibiotics and the immune system's response in the treatment of pulmonary TB.
AI-driven Closed-loop Automation in 5G and beyond Mobile Networks (2021)

The 5th Generation (5G) mobile networks support a wide range of services that impose diverse and stringent QoS requirements. This will be further exacerbated with the evolution towards 6th Generation mobile networks. Inevitably, 5G and beyond mobile networks must provide stricter, differentiated QoS guarantees to meet the increasing demands of future applications, which cannot be satisfied with traditional human-in-the-loop service orchestration and network management approaches. In this paper, we lay out our vision for closed-loop service orchestration and network management of 5G and beyond mobile networks. We extend the MAPE (i.e., monitor, analyze, plan, and execute) control loop to facilitate closed-loop automation, and discuss the quintessential role of Artificial Intelligence/Machine Learning in its realization. We also instigate open research challenges for closed-loop automation of 5G and beyond mobile networks.
Multi-Band Wi-Fi Sensing With Matched Feature Granularity (2022)

Complementary to the fine-grained channel state information (CSI) and coarse-grained received signal strength indicator (RSSI) measurements, the mid-grained spatial beam attributes [i.e., beam SNR (bSNR)] during the millimeter-wave (mmWave) beam training phase were recently repurposed for Wi-Fi sensing applications, such as human activity recognition and indoor localization. This article proposes a multiband Wi-Fi sensing framework to fuse features from both CSI from 5-GHz bands and the mid-grained bSNR at 60 GHz with feature granularity matching (GM) that pairs feature maps from the CSI and bSNR at different granularity levels with learnable weights. To address the issue of limited labeled training data, we propose to pretrain an autoencoder-based multiband Wi-Fi fusion network in an unsupervised fashion. For specific sensing tasks, separate sensing heads can be attached to the pretrained fusion network with fine-tuning. The proposed framework is thoroughly validated for three sensing applications using in-house experimental data sets: 1) pose recognition; 2) occupancy sensing; and 3) indoor localization. Comparison to a list of baseline methods demonstrates the effectiveness of GM. An ablation study is performed as a function of the amount of labeled data, the latent space dimension, and learning rates.
Dynamic nuclear polarization experiments at 14.1 T for solid-state NMR (2010)

Instrumentation for high-field dynamic nuclear polarization (DNP) at 14.1 T was developed to enhance the nuclear polarization for NMR of solids. The gyrotron generated 394.5 GHz submillimeter (sub-mm) wave with a power of 40 W in the second harmonic TE(0,6) mode. The sub-mm wave with a power of 0.5-3 W was transmitted to the sample in a low-temperature DNP-NMR probe with a smooth-wall circular waveguide system. The (1)H polarization enhancement factor of up to about 10 was observed for a (13)C-labeled compound with nitroxyl biradical TOTAPOL. The DNP enhancement was confirmed by the static magnetic field dependence of the NMR signal amplitude at 90 K. Improvements of the high-field DNP experiments are discussed.
ChemInform Abstract: IR Transmission Spectroscopy of Silver Zeolite A. (1989)

Abstract A new FTIR technique covering the spectral range 20‐13800 cm ‐1 is used for detailed investigations of the interaction of metal exchanged zeolites with gaseous reactants such as H 2 O, D 2 O, CO, CO 2 , H2, and D2.
Magnetic resonance imaging urodynamics: technique development and preliminary results (2006)

The concept of MRI video urodynamics is feasible. In a clinical perspective, practical aspects represent a barrier to daily use and it should be recommended for research purposes.
Aqueous Diels-Alder Reactions of Electron Deficient 2-Arylfurans: A Highly Stereoselective Route to 2,2,5-Trisubstituted Tetrahydrofurans towards a Novel Class of Orally Active Azole Antifungals (1993)

with either I or 6-under the abovenon-aqueous conditions36 failedio provide the desired adducts.Wc have not studied these reactions under Lewis acid catalysis or high pressure conditions.
Robust depth-map estimation from image sequences with precise camera operation parameters (2000)

The depth-map of a scene conveys the fundamental information that is extremely useful for object segmentation, compact representation of videos, etc. We present an algorithm for robust depth-map estimation from image sequences with precise camera operation parameters. This algorithm exploits precise camera operation parameters to find correspondence points among multiple frames of an image sequence of a static scene. Our algorithm is able to deal with arbitrary camera movement. The experimental results show significant improvement in the accuracy of depth-maps compared with the conventional two-frame matching method.
CLAIRE: Combining Sets, Search and Rules to Better Express Algorithms (1999)

This paper presents a programming language which includes paradigms that are usually associated with declarative languages, such as sets, rules and search, into an imperative (functional) language. Although these paradigms are separately well known and are available under various programming environments, the originality of the CLAIRE language comes from the tight integration, which yields interesting run-time performances, and from the richness of this combination, which yields new ways in which to express complex algorithmic patterns with few elegant lines. To achieve the opposite goals of a high abstraction level (conciseness and readability) and run-time performance (CLAIRE is used as a C++ preprocessor), we have developed two kinds of compiler: first, a pattern pre-processor handles iterations over both concrete and abstract sets (data types and program fragments), in a completely user-extensible manner; secondly, an inference compiler transforms a set of logical rules into a set of functions (demons that are used through procedural attachment).