gebhart/patrepeval huggingface dataset:
Syndrome of Inappropriate Antidiuresis in Small‐Cell Lung Cancer (1987)

Patients with small-cell lung cancer and hyponatremia were examined for the syndrome of inappropriate antidiuresis (SIAD). A comparison was made between the definition based on hyponatremia, serum hypoosmolality and urine hyperosmolality (classic SIAD, 12 patients) and a definition based on measurement of plasma ADH concentration by radioimmunoassay (RIA-SIAD, nine patients) and patients without SIAD (eight patients). A standard water load test was performed as a reference before initiation of cytostatic treatment. All tests were repeated if remission of the malignant disease occurred. RIA-SIAD patients were a subgroup of classic SIAD patients, with more pronounced homeostatic abnormalities. Biochemical abnormalities were reduced after tumor regression but a completely normal renal water handling was achieved in only few patients, even when complete remission of the tumor was achieved, presumably due to the persistence of subclinical disease. However, an effect of other yet unknown factors might be of influence.
Magnetic spectroscopy at high pressures using X-ray magnetic circular dichroism (2008)

The imbalance in the electronic density of states between spin-up and spin-down electrons characteristic of ferro(ferri)-magnetic materials gives rise to X-ray magnetic circular dichroism (XMCD) in the absorption of circularly polarized X-rays with opposite helicity. These dichroic effects are largest near element-selective atomic resonances and can be used to probe ferro(ferri)-magnetic ordering with element- and electronic orbital-selectivity. We describe recent developments at the Advanced Photon Source that allow measurements of XMCD in a diamond anvil cell. We discuss the challenges associated with these measurements as well as their potential to further our understanding of complex magnetic materials.
On Using Cloud Platforms in a Software Architecture for Smart Energy Grids (2010)

We report on the results of extensive optical measurements on the ferroelectric smectic-C* phase of the chiral liquid crystal 4-(2(') methyl butyl) phenyl 4(')-n-octylbiphenyl-4-carboxylate. We have explored the entire temperature-electric-field phase space searching for all possible phase transitions in the C* region and have characterized them both as to their character, including whether they are first or second order, and also whether they are of instability or nucleation type. Our results lead us to conclude that the experimental phase diagram is incompatible with all existing theoretical models for the C* phase transitions. We propose instead a phase diagram where two second-order lines and one first-order line meet at a triple point that we tentatively identify as a Lifshitz point.
A Study on Ultraviolet Protection of 100% Cotton Knitted Fabric: Effect of Fabric Parameters (2014)

The effect of fabric parameters such as weight, thickness, and stitch density on the ultraviolet (UV) protection of knitted fabrics was studied. Different knitting structures such as plain, pineapple, lacoste, and other combinations of different knitting stitches of knit, tuck, and miss as well as half milano, full milano, half cardigan, full cardigan, 1 × 1 rib, and interlock were prepared. Experimental results revealed that weight was the most important factor that affected UV protection while thickness and stitch density were not the leading factor in determining UV protection.
[Does the ferritin level have a practical value in chronically hemodialized patients?]. (1984)

In order to determine whether serum ferritin assay has any advantages compared with usual hematologic parameters, serum ferritin was assessed in 70 hemodialysed patients. It was positively correlated with the number of blood units infused, but there was no correlation with iron treatment, serum iron or the degree of anemia. However, the interpretation of the results is difficult, because of the large dispersion of serum ferritin levels. Therefore, the determination of serum ferritin concentration cannot be recommended as a current method to follow-up and manage anemic chronic hemodialysed patients, especially when the cost of the test is taken into account.
Children’s development of humour in everyday interactions: two case-studies in French and Brazilian Portuguese (2020)

In order to understand how children learn to recognize and use humor in their own cultural environment, we have chosen to study their production in two different languages and cultures. We studied a French-speaking monolingual child and a Brazilian Portuguese-speaking child, video-recorded once a month up to seven years old. The detailed multimodal linguistic coding of our data enabled us to draw the multimodal paths the two children followed from the first instances of shared amusement initiated by the adult, expressed mainly through reactive behavior such as laughing, to the children’s own verbal production of successful humor in dialogue. Our study demonstrates that the production of children’s humor is closely linked to the family input (their micro-culture), and to children’s multimodal linguistic and meta-cognitive development. We did not observe important differences between the two children at the macro-cultural level, but there were noticeable inter-individual differences.
Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo (1996)

Quantitative measurement of oxygen concentrations in the microvasculature is of prime importance in issues related to oxygen transport to tissue. The introduction of the quenching of the Pd-porphyrin phosphorescence as oxygen sensor in vivo by Wilson et al. (J. Appl. Physiol. 74: 580-589, 1993) has provided in this context a major advance in this area of research. For in vivo application, the dye is coupled to albumin to restrict the dye to the circulation and to measure oxygen in the physiological range. In this study a phosphorimeter with a gated photomultiplier is presented and validated. Furthermore, a nonlinear-fit method using the Marquardt-Levenberg algorithm is used to calculate the decay time. With this new phosphorimeter, calibration measurements were performed to investigate the effects of pH, temperature, and diffusivity. The results present a preparation method for albumin coupling of the dye that eliminates the pH dependency of the quenching kinetics. Furthermore, the decreased oxygen diffusivity of serum was compared with that of water, and it was shown that calibration constants measured in water can be extrapolated to serum.
Preparation and Characterization of Homogeneous YBCO Single Crystals with Doping Level near the SC-AFM Boundary (2001)

High-purity and homogeneous YBa2Cu3Oy single crystals with carrier doping level near the AFM-SC boundary have been obtained in the oxygen content range between y = 6.340 and 6.370. The crystals are ortho-II phase at room temperature and undergo the orthorhombic to tetragonal transition at about 140_Degree_C. They show sharp superconducting transitions, with Tc between 4 and 20 K. Tc changes by 0.8 K when the oxygen content y is changed by 0.001, and is also sensitive to annealing conditions near room temperature, due to the dependence of doping on oxygen ordering correlation lengths. Crystals with oxygen content y lower than 6.345 are non-superconducting.
Antimicrobial activity of Vitex agnus-castus Essential Oil and Molecular Docking Study of Its Major Constituents (2020)

Antimicrobial resistance represents a public health problem worldwide that is associated with high morbidity and mortality which rose up the need for natural products as being an effective alternative. This study aims to evaluate the antimicrobial activity of the Vitex agnus-cactus L. essential oil (EO) towards bacterial and fungal strains of economic importance, besides, correlating its chemical constituents to the observed antimicrobial and antifungal activity using molecular docking. The chemical composition of essential oil was analyzed by gas chromatography-mass spectroscopy (GC-MS), where oxygenated monoterpenes (44.98 %) and monoterpenes (32.2 %) represented the major classes. Molecular docking study was carried out for the major identified essential oil constituents against bacterial protein targets, where, sabinene, 1,8 cineole, and linalool (the major oil constituents) acted on multi targets and reflected the effective antibacterial activity. Additionally, caryophyllene and verticiol showed a high binding affinity to Candida’s Farnesyl pyrophosphate synthase, a critical enzyme responsible for cell membrane integrity. V. agnus-cactus L. oil demonstrated itself as a powerful anticandidal agent providing a possible candidate in the pharmaceutical formulations.
From classical mendelian randomization to causal networks for systematic integration of multi-omics (2022)

The number of studies with information at multiple biological levels of granularity, such as genomics, proteomics, and metabolomics, is increasing each year, and a biomedical questaion is how to systematically integrate these data to discover new biological mechanisms that have the potential to elucidate the processes of health and disease. Causal frameworks, such as Mendelian randomization (MR), provide a foundation to begin integrating data for new biological discoveries. Despite the growing number of MR applications in a wide variety of biomedical studies, there are few approaches for the systematic analysis of omic data. The large number and diverse types of molecular components involved in complex diseases interact through complex networks, and classical MR approaches targeting individual components do not consider the underlying relationships. In contrast, causal network models established in the principles of MR offer significant improvements to the classical MR framework for understanding omic data. Integration of these mostly distinct branches of statistics is a recent development, and we here review the current progress. To set the stage for causal network models, we review some recent progress in the classical MR framework. We then explain how to transition from the classical MR framework to causal networks. We discuss the identification of causal networks and evaluate the underlying assumptions. We also introduce some tests for sensitivity analysis and stability assessment of causal networks. We then review practical details to perform real data analysis and identify causal networks and highlight some of the utility of causal networks. The utilities with validated novel findings reveal the full potential of causal networks as a systems approach that will become necessary to integrate large-scale omic data.
Abstract 5288: MPNST treatment and diagnosis in NF1: A health economic model (2018)

Abstract Biomarkers have many applications along the care process in rare cancers and have potential to optimize treatment decisions. However, many diagnostic tests struggle to gain market access and appropriate value in terms of payer coverage because of a lack of evidence on their health economic benefit to patients. CMS reimbursement guidelines, of cost-plus pricing for diagnostics does not always work for niche small rare disease subpopulations. Nor does it reflect the lifelong value of effective patient care. To address this, we have developed a cost benefit model for early diagnostic intervention, based on retrospective data to determine mutation status and monitor for disease progression in people diagnosed with neurofibromatosis type 1 (NF1) and soft tissue tumors. NF1 is an autosomal dominant hereditary cancer syndrome that affects around 1:2,500 people and is caused by mutations in the NF1 gene. 50% of patients can have few to many neurofibroma which vary in clinical behavior from benign to malignant. About 10% of people can develop malignant peripheral nerve sheath tumors (MPNSTs) thought to develop from pre-existing benign neurofibroma. Currently, there is no reliable way of knowing which individual and which tumors are malignant. MPNSTs are often difficult to diagnose in the early phases with current imaging methods like CT or MRI. Overall, these patients face a lifetime risk of cancer up to 16-26% higher than the normal population. Once metastasizes MPNSTs are associated with poor prognosis, less than 25% survival rate at 5 years. We built a model used retrospective anonymized patient treatment records to demonstrate cost and risk based benefits to patients, payers and clinical practitioners, on the effect of early intervention versus late on treatment cost, and patient outcome in the long-term care process. For NF1 patients. In conclusion, our model proposes a new framework to engage healthcare insurers and managed care physician groups in the US to quantify the health economic benefits of prognostic biomarker tests in patient populations with a lifelong genetic predisposition to cancer. Citation Format: Lydia Turkson, Hannah Mamuszka, Kyla Grimshaw, Erica Marie Marshall. MPNST treatment and diagnosis in NF1: A health economic model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5288.
Breakpoint identification and smoothing of array comparative genomic hybridization data (2004)

aCGH-Smooth is free for researchers at academic and non-profit institutions at http://www.few.vu.nl/~vumarray/.
Cell Based Therapy for Chronic Liver Disease: Role of Fetal Liver Cells in Restoration of the Liver Cell Functions (2012)

Cell Based Therapy for Chronic Liver Disease: Role of Fetal Liver Cells in Restoration of the Liver Cell Functions
In the right words: addressing language and culture in providing health care. (2003)

As part of its continuing mission to serve trustees, executives, and staff of health foundations and corporate giving programs, Grantmakers In Health (GIH) convened a group of experts from philanthropy, research, health care practice, and policy on April 4, 2003, to discuss the roles of language and culture in providing effective health care. During this Issue Dialogue, In the Right Words: Addressing Language and Culture in Providing Health Care, health grantmakers and experts from policy and practice participated in an open exchange of ideas and perspectives on language access and heard from fellow grantmakers who are funding innovative programs in this area. Together they explored ways to effectively support comprehensive language services, including the use of interpreters and translation of written materials. This Issue Brief synthesizes key points from the day's discussion with a background paper previously prepared for Issue Dialogue participants. It focuses on the challenges and opportunities involved with ensuring language access for the growing number of people who require it. Sections include: recent immigration trends and demographic changes; the effect of language barriers on health outcomes and health care processes; laws and policies regarding the provision of language services to patients, including an overview of public financing mechanisms; strategies for improving language access, including enhancing access in delivery settings, promoting advocacy and policy change, improving interpreter training, and advancing research; and roles for foundations in supporting improved language access, including examples of current activities. The Issue Dialogue focused mainly on activities and programs that ensure linguistic access to health care for all patients. Although language and culture are clearly inseparable, a full exploration of the field of cultural competence and initiatives that promote its application to the health care setting are beyond the scope of this Issue Brief. The day's discussion did, however, raise provocative issues of culture that are reflected throughout this report.
New concepts on the pathogenesis of autoimmune diseases (2001)

info:eu-repo/semantics/published
Mutual information statistics for dual MIMO systems in correlated Rayleigh fading (2006)

In this letter, we derive very simple and exact expressions for the mutual information (MI) distributions under isotropic Gaussian input of dual multiple-input multiple-output (MIMO) systems, where the minimum number of antennas at either side of the wireless link is two, in a semicorrelated Rayleigh fading environment with correlation at the dual-antenna side only. Furthermore, exact closed-form expressions for the MI moments (mean, variance), and other higher order statistics, such as the skewness and kurtosis, are derived. The proposed methodology for evaluating the MI statistics, is easily extendable to other multielement antenna settings such as single-input multiple-output (SIMO), multiple-input single-output (MISO) and dual MIMO systems for both uncorrelated and semicorrelated Rayleigh fading, where correlation can be assumed at the side with the largest number of antennas
Phase-field modelling of ternary eutetic solidification in hot dip galvanization (2017)

Continuous hot dip galvanizing is one of the commercially most important process techniques used for protecting steel sheets against corrosion. Preheated steel sheets are con-tinuously drawn through a pot with a molten zinc alloy. After passing a gas jet that controls the layer thickness multiple cooling units act to cool down the sheet. During passing these aggregates nucleation, dendritic primary solidification and the formation of a binary and ter-nary eutectic occurs. In the present paper, the coupled modelling of macroscopic heat flow, multiphase thermodynamics and crystal growth during solidification of a Zn-2.5 wt.% Al-1.5 wt.% Mg alloy is presented. The heat flow problem requires a numerical domain in the order of meters, growth of primary Zn-dendrites in the order of several hundred micrometers, and the interdendritic eutectic in the order of several nanometers. For technical alloys like the ternary system considered here, a thermodynamic database has been online linked to a phase-field model to describe phase transformations including all occurring solid/liquid or sol-id/solid interfaces. Process simulations have been used for getting appropriate thermal bound-ary conditions for 3D phase field simulations which were performed at three different length-scales. For modelling primary dendritic Zn-a seed density model was used for predicting the grain structure within the Zn layer. At a smaller length-scale, a small part of a Zn-dendrite surface was taken as starting point for simulating the transition between primary binary eutec-tic and ternary eutectic coupled growth of Zn-rich, Al-rich, and MgZn2-phases. Finally, the morphology of the ternary eutectic has been evaluated at the smallest length scale. The com-parison with real solidification microstructure reveals encouraging agreements.
Liquid surface tension and refractive index sensor based on a tilted fiber Bragg grating (2018)

A refractive index (RI) and liquid surface tension (ST) (at the level of 10&#x2212;3&#x2009;&#x2009;N) measurement system has been proposed by using a 1.80-cm-long, 8&#x00B0;-tilted fiber Bragg grating (TFBG). When the TFBG is pulled up from the liquid into the air at a fixed height (corresponding to a fixed contact angle between the fiber and the liquid), the ST acting upon the TFBG depends on the length of the TFBG covered with the liquid film along the fiber axis direction. The liquid film covering the grating results in the shifts of the resonant cladding modes of the TFBG. For the liquid with an RI in the range from 1.3341 to 1.4415, its RI and ST can be obtained through the measurements of shifts in the resonant wavelengths of the cutoff mode and changes in the intensities of the resonant wavelength dips in the TFBG spectrum by using the known ST and RI of water as a reference.
Direct evidence for loss of human suppressor cells during active autoimmune disease. (1978)

These studies indicate that a regulatory subset of lymphocytes is missing in patients with juvenile rheumatoid arthritis but these patients have antibodies in their serum that react with normal T cells. This regulatory subset of T cells is, however, present in patients whose serum shows little or no reactivity with normal T cells. In addition, patients who are deficient in this regulatory subset of lymphocytes significantly higher numbers of cells secreting Ig as measured by a hemolytic plaque assay. The significance of these observations is twofold: first, they represent a positive relationship among the loss of regulation overproduction of immunoglobulin, and the presence of anti-T cell antibodies and second and perhaps of equal importance, is the indication that serum from patients with autoimmune diseases may give us a readily available reagent with which to dissect further functionally distinct subsets of normal T cells in man.
Greater Philadelphia Bioinformatics Alliance (GPBA) 3rd Annual Retreat 2005 (2005)

Abstract : Community structure is a topological property common to many networks. We present in this paper an efficient and accurate approach to detecting a community in a protein-protein interaction network from a given seed protein. Our experimental results show strong structural and functional relationships among member proteins within each of the communities identified by our approach, as verified by MIPS complex catalogue database and annotations.
t‐Bu‐Amphos—RhCl3×3H2O: A Highly Recyclable Catalyst System for the Cross‐Coupling of Aldehydes and Aryl‐ and Alkenylboronic Acids in Aqueous Solvents. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Array processing techniques for broadband mode estimation (1997)

Normal mode representations are useful in many aspects of underwater acoustics, e.g., modal acoustic tomography uses precise measurements of the travel time of broadband pulses to invert for environmental parameters. A thorough understanding of the resolution of mode estimators is crucial for tomographic applications. Typically, acoustic modes are used for describing and analyzing the temporal and spatial structure of narrow-band signals. As source bandwidth increases, however, mode estimation algorithms can no longer ignore frequency variations of the modal wave numbers, which result in temporal dispersion and frequency-dependent mode shapes. To address the issue, this study establishes an array processing framework for estimating the modal composition of broadband receptions. Within this framework, the time/frequency resolution tradeoffs inherent in the processing of modal pulse arrivals are explored. Specifically, the effects of mode shape frequency variations on standard modal beamformers are investigated. In addition to characterizing the performance of spatial filters for mode separation, this study considers the problem of designing receivers to compensate for the dispersion (pulse-spreading) introduced by the waveguide. Techniques developed through theoretical work have been applied to data from the Acoustic Thermometry of Ocean Climate (ATOC) project. Some results of modal time series analysis for 1996 ATOC receptions are presented.
Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation (2015)

The application of the Rho-kinase inhibitor will be beneficial when culturing pCECs, and may provide a novel therapy to reduce inflammation after corneal xenotransplantation.