gebhart/patrepeval huggingface dataset:
Tampoprint inspection by artificial vision (2002)

In this paper an application of artificial vision to production line quality control is described. This work has lead to the creation of an inspection system for tampoprint impressions on plastic casings. The specificity of the process and the economic constraints of the project specifications drove the originators to develop an all software product which uses standard material only. The originality of the presented solution lies in the optimal exploitation of camera resolution (256/spl times/256 pixels). It uses, in particular, an adaptive thresholding algorithm on the difference image resulting from the comparison between a reference image and the tampoprint image, after subpixel alignment by subimages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity (1998)

This study was performed to examine the neuroprotective action of bifemelane against glutamate cytotoxicity in cultured cortical neurons obtained from fetal rats. Cell viability was markedly reduced by a brief exposure to glutamate. Glutamate cytotoxicity was reduced by exposing cultures to bifemelane at concentrations of 1-10 microM for 24 hr prior to glutamate exposure. In contrast, glutamate cytotoxicity was not affected by adding bifemelane to the glutamate-containing-medium without pretreatment. Bifemelane did not affect N-methyl-D-aspartate (NMDA)-induced currents, although the higher concentration (100 microM) of the drug reduced them. These findings suggest that bifemelane protects against glutamate neurotoxicity without affecting NMDA receptors.
ChemInform Abstract: SYNTHESIS OF OPTICALLY ACTIVE (+)‐19‐NORTESTOSTERONE BY ASYMMETRIC BIS‐ANNULATION REACTION (1980)

Abstract 2‐Methyl‐1,3‐cyclopentandion (II) reagiert mit dem Dienon (I) zu einem Addukt (III), das in Gegenwart von optisch aktiven Aminosäuren unter optischer Induzierung zu (IV) cyclisiert wird.
Heating of liquid substrate by low-pressure sputtering plasma (2022)

The heating of the liquid substrate by low-pressure (∼1 Pa) sputtering plasma has been investigated by in situ temperature measurements. The combination of “green” non-toxic solvent, castor oil, copper target, and direct current magnetron sputtering was chosen as a model system. The temperature increase induced by plasma was registered with two thermocouples placed immediately under the liquid surface and in the bulk solution. The effect of the working gas pressure and sputter power was studied. It was shown that the liquid temperature increases at a rate of up to 1 °C/min, depending on the sputtering conditions. The experimental data were compared with numerical calculations and COMSOL simulation. Provided information is essential data for the detailed explanation of the formation of nanoparticles during sputtering onto liquids, a clean approach for production of colloidal solutions of “naked” nanoparticles.
The Stomach Anatomy of Some Eastern North american Margaritiferidae (Unionoida, Unionacea) (1986)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation (2018)

As there are no immediate cures for food allergy or asthma, early intervention aimed at protecting the skin barrier and effective control of local and systemic inflammation may improve long-term outcomes and reduce allergen sensitization in the airway and gut.
Analogues of a lupane-type triterpene as potential anti-HIV agents (2011)

Infection with human immunodeficiency virus (HIV), the etiologic agent of acquired immunodeficiency syndrome (AIDS), continues to be ranked high on the list of the most important health issues facing the world. Although significant progress has been made since the introduction of highly active antiretroviral therapy, it has also led to increased adverse effects and the emergence of multidrug-resistant viral strains. Therefore, there is a need for new classes of drugs involving novel molecular mechanisms [1].
Results From DEFUSE 3 (2019)

Background and Purpose- The effect of leptomeningeal collaterals for acute ischemic stroke patients with large vessel occlusion in the late window (>6 hours from last known normal) remains unknown. We sought to determine if collateral status on baseline computed tomography angiography impacted neurological outcome, ischemic core growth, and moderated the effect of endovascular thrombectomy in the late window. Methods- This is a prespecified analysis of DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke). We included patients with computed tomography angiography as their baseline imaging and rated collateral status using the validated scales described by Tan and Maas. The primary outcome is functional independence (modified Rankin Scale score of ≤2). Additional outcomes include the full range of the modified Rankin Scale, baseline ischemic core volume, change from baseline in the ischemic core volume at 24 hours, and death at 90 days. Results- Of the 130 patients in our cohort, 33 (25%) had poor collaterals and 97 (75%) had good collaterals. There was no difference in the rate of functional independence with good versus poor collaterals in unadjusted analysis (30% versus 39%; P=0.3) or after adjustment for treatment arm (odds ratio [95% CI], 0.61 [0.26-1.45]). Good collaterals were associated with significantly smaller ischemic core volume and less ischemic core growth. The difference in the treatment effect of endovascular thrombectomy was not significant ( P=0.8). Collateral status also did not affect the rate of stroke-related death (n [%], good versus poor collaterals, 18/97 [19%] versus 8/33 [24%], P=0.5]. Conclusions- In DEFUSE 3 patients, good leptomeningeal collaterals on single phase computed tomography angiography were not predictive of functional independence or death and did not impact the treatment effect of endovascular thrombectomy. These unexpected findings require further study to confirm their validity and to better understand the role of collaterals for stroke patients with anterior circulation large vessel occlusion in the late therapeutic window. Clinical Trial Registration- URL: https://www.clinicaltrials.gov . Unique identifier: NCT02586415.
Framed Structures: Detection of Building Torsional Modes Using a Simplified Experimental Approach (2014)

Heavy structural damage on buildings subjected to seismic motion is frequently due to torsional effects. These effects have been extensively studied in the last years and incorporated in seismic codes. The standard approach for the experimental evaluation of such effects involves the installation of a multi-channel accelerometric system on buildings, either for continuous monitoring of earthquakes or to record forced vibrations. This time- and resource-consuming approach is usually applied to single buildings, but cannot be used in large scale studies in order to validate, as example, building code provisions or for a quick estimations of building dynamic properties during large scale vulnerability evaluations. In this paper a simplified experimental approach based on ambient vibration recordings, which is widely used for the dynamic characterization of structures, has been proposed. In order to test the proposed approach experimental tests have been performed. Several sensor configurations have been tested. Using just two three-directional seismic stations installed at the top floor of a building it is possible to identify the most important building eigenfrequencies related to torsional modes. On the contrary, installing at least one station for each floor it is possible to identify also the mode shapes. In order to validate the proposed technique a comparison between the results provided from the proposed technique (using velocimeters), and those obtained from another full experimental campaign (using accelerometers) performed on a two-story steel frame at the University of Basilicata, have been compared.
64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET Radiotracer Targeting Neuroblastoma and Melanoma (2012)

(64)Cu-p-NH(2)-Bn-DOTA-hu14.18K322A represents a novel PET radiotracer to facilitate clinical investigations of anti-GD2 immunotherapies and to complement other imaging modalities in the staging and treatment of neuroblastoma.
Chromosome Translocation in Peripheral Neuroepithelioma (1984)

PERIPHERAL neuroepithelioma (peripheral neuroblastoma) is an uncommon malignant tumor of the peripheral nervous system with a histologic appearance similar to that of classical childhood neuroblastoma.1 2 3 In contrast to neuroblastoma, it typically presents in older children and young adults, it can be associated with peripheral nerves, and it spares the adrenal glands and sympathetic ganglia.We have studied both tumor specimens and tumor-cell lines from two patients with peripheral neuroepithelioma; in each case, we found these karyotypes to include an rcp(11;22)(q24;q12) indistinguishable from the one that has been reported in Ewing's sarcoma.4 , 5 This finding supports the hypothesis that these two entities . . .
Rotational Landmarks and Sizing of the Distal Femur in Total Knee Arthroplasty (1996)

In 100 knees undergoing a total replacement, the angles between the tangent line of the posterior condylar surfaces, the anteroposterior axis as described by Whiteside, the transepicondylar line, and the trochlear line were measured. Also measured were the sulcus angle, the transepicondylar width, the height of the condyles, and the thickness of the various cuts. Radiologic measurements made were: the mechanical angle, the hip center-femoral shaft angle, the transcondylar angle, and the tibial plateau-tibial shaft angle. The mean values of these measurements were calculated, and comparisons were made according to gender and the mechanical axis using the Student's t test. Correlations between the various measurements were calculated. The transepicondylar axis was found to be a reliable landmark to properly rotate the femoral component, and was easier to locate at surgery than the anteroposterior axis. In trochlear dysplasia and in some valgus knees, relying on the anteroposterior axis can induce an excessive external rotation of the femoral component, and the opposite can happen in some varus knees. The anterior extent of the condyles is highly variable in arthritic knees, and cannot be used to orient the prosthesis. The ratio between the transepicondylar width and the height of the condyles is constant, but some narrow femora could require narrower implants to avoid medial-lateral overhang of the femoral component.
Metal nanofilm in strong ultrafast optical fields (2013)

We predict that a metal nanofilm subjected to an ultrashort (near-single oscillation) optical pulse of a high field amplitude $\ensuremath{\gtrsim}$$3\phantom{\rule{0.28em}{0ex}}\mathrm{V}/\AA{}$ at normal incidence undergoes an ultrafast (at subcycle times $\ensuremath{\lesssim}$$1\phantom{\rule{0.28em}{0ex}}\mathrm{fs}$) transition to a state resembling semimetal. Its reflectivity is greatly reduced, while its transmissivity and the optical field inside the metal are greatly increased. Despite the metal being a centrosymmetric medium, the strong pulse causes net charge transfer in the direction determined by the carrier envelope phase (CEP) of the pulse, which is opposite to the direction of the maximum field.
Minimum variance guided wave imaging in a quasi-isotropic composite plate (2011)

Ultrasonic guided waves are capable of rapidly interrogating large, plate-like structures for both nondestructive evaluation and structural health monitoring (SHM) applications. Distributed sparse arrays of inexpensive piezoelectric transducers offer a cost-effective way to automate the interrogation process. However, the sparse nature of the array limits the amount of information available for performing damage detection and localization. Minimum variance techniques have been incorporated into guided wave imaging to reduce the magnitude of imaging artifacts and improve the imaging performance for sparse array SHM applications. The ability of these techniques to improve imaging performance is related to the accuracy of a priori model assumptions, such as scattering characteristics and dispersion. This paper reports the application of minimum variance imaging under slightly inaccurate model assumptions, such as are expected in realistic environments. Specifically, the imaging algorithm assumes an isotropic, non-dispersive, single mode propagating environment with a scattering field independent of incident angle and frequency. In actuality, the composite material considered here is not only slightly anisotropic and dispersive but also supports multiple propagating modes, and additionally, the scattering field is dependent on the incident angle, scattered angle, and frequency. An isotropic propagation velocity is estimated via calibration prior to imaging to implement the non-dispersive model assumption. Imaging performance is presented under these inaccurate assumptions to demonstrate the robustness of minimum variance imaging to common sources of imaging artifacts.
PHYSIOLOGIC AND THERMAL RESPONSES OF MALE AND FEMALE PATIENTS WITH MULTIPLE SCLEROSIS TO HEAD AND NECK COOLING1 (1999)

Personal cooling systems are used to alleviate symptoms of multiple sclerosis and to prevent increased core temperature during daily activities. The objective of this study was to determine the thermal and physiologic responses of patients with multiple sclerosis to short-term maximal head and neck cooling. A Life Support Systems, Inc. Mark VII portable cooling system and a liquid cooling helmet were used to cool the head and neck regions of 24 female and 26 male patients with multiple sclerosis in this study. The subjects, seated in an upright position at normal room temperature (approximately 22 degrees C), were cooled for 30 min by the liquid cooling garment, which was operated at its maximum cooling capacity. Oral, right, and left ear temperatures and cooling system parameters were logged manually every 5 min. Forearm, calf, chest, and rectal temperatures, heart rate, and respiration rate were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. This protocol was performed during the winter and summer to investigate the seasonal differences in the way patients with multiple sclerosis respond to head and neck cooling. No significant differences were found between the male and female subject group's mean rectal or oral temperature responses during any phase of the experiment. The mean oral temperature decreased significantly (P < 0.05) for both groups approximately 0.3 degrees C after 30 min of cooling and continued to decrease further (approximately 0.1-0.2 degrees C) for a period of approximately 15 min after removal of the cooling helmet. The mean rectal temperatures decreased significantly (P < 0.05) in both male and female subjects in the winter studies (approximately 0.2-0.3 degrees C) and for the male subjects during the summer test (approximately 0.2 degrees C). However, the rectal temperature of the female subjects did not change significantly during any phase of the summer test. These data indicate that head and neck cooling may, in general, be used to reduce the oral and body temperatures of both male and female patients with multiple sclerosis by the approximate amount needed for symptomatic relief as shown by other researchers. However, thermal response of patients with multiple sclerosis may be affected by gender and seasonal factors, which should be considered in the use of liquid cooling therapy.
Titelbild (2001)

Das Titelbild zeigt niedermolekulare Verbindungen, die nach einer neuen Methode, die Anwendung in der Proteomanalyse finden könnte, in einem räumlich adressierbaren Format angeordnet wurden. Jede niedermolekulare Verbindung (als Kalottenmodell dargestellt) ist an einen Peptidnucleinsäure(PNA)-Marker (gelbes Band) gebunden, der den Ablauf der Synthese der niedermolekularen Verbindung kodiert. Nach dem Durchmustern der Bibliothek potentieller Proteinliganden mit einer Proteinprobe erfolgt die Hybridisierung mit einem Oligonucleotid-Mikro-Array, um die biologisch aktiven Verbindungen und/oder die Aktivität der Proteine zu bestimmen. Einzelheiten über diese Methode beschreiben Schultz und Mitarbeiter auf S. 3254 ff. (Das Bild wurde von einem der Coautoren, Nicolas Winssinger, erstellt.)
Ask The Experts: Current Obstacles and Future Developments in Cell Culture (2019)

In this 'Ask the experts' feature, a panel of international experts share their perspective on
Inspection of Complex Objects Using Multiple-X-Ray Views (2014)

This paper presents a new methodology for identifying parts of interest inside of a complex object using multiple-X-ray views. The proposed method consists of five steps: 1) image acquisition, that acquires an image sequence where the parts of the object are captured from different viewpoints; 2) geometric model estimation, that establishes a multiple-view geometric model used to find the correct correspondence among different views; 3) single-view detection, that segment potential regions of interest in each view; 4) multiple-view detection, that matches and tracks potential regions based on similarity and geometrical multiple-view constraints; and 5) analysis, that analyzes the tracked regions using multiple-view information, filtering out false alarms without eliminating existing parts of interest. In order to evaluate the effectiveness of the proposed method, the algorithm was tested on 32 cases (five applications using different segmentation approaches) yielding promising results: precision and recall were 95.7% and 93.9%, respectively. Additionally, the multiple-view information obtained from the tracked parts was effectively used for recognition purposes. In our recognition experiments, we obtained an accuracy of 96.5%. Validation experiments show that our approach achieves better performance than other representative methods in the literature.
Design of a high gain circularly polarized microstrip antenna (2011)

Circularly polarized microstrip antennas catch more and more eyes in military applications with its low profile, conformality, easy integration and good concealment, etc. This paper provides from a practical viewpoint a design of small-sized compact wide-band circularly polarized microstrip antenna with an dual capacitively coupled feeds. The antenna has the advantages of simple feeding ang band width,ideal for a circularly polarized design.
Nbn−Mre11 interaction is required for tumor suppression and genomic integrity (2019)

We derived a mouse model in which a mutant form of Nbn/Nbs1<sup>mid8</sup> (hereafter Nbn<sup>mid8</sup>) exhibits severely impaired binding to the Mre11-Rad50 core of the Mre11 complex. The <i>Nbn</i><sup><i>mid8</i></sup> allele was expressed exclusively in hematopoietic lineages (in <i>Nbn</i><sup><i>-/mid8vav</i></sup> mice). Unlike <i>Nbn</i><sup><i>flox/floxvav</i></sup> mice with Nbn deficiency in the bone marrow, <i>Nbn</i><sup><i>-/mid8vav</i></sup> mice were viable. <i>Nbn</i><sup><i>-/mid8vav</i></sup> mice hematopoiesis was profoundly defective, exhibiting reduced cellularity of thymus and bone marrow, and stage-specific blockage of B cell development. Within 6 mo, <i>Nbn</i><sup><i>-/mid8</i></sup> mice developed highly penetrant T cell leukemias. <i>Nbn</i><sup><i>-/mid8vav</i></sup> leukemias recapitulated mutational features of human T cell acute lymphoblastic leukemia (T-ALL), containing mutations in <i>NOTCH1</i>, <i>TP53</i>, <i>BCL6</i>, <i>BCOR</i>, and <i>IKZF1</i>, suggesting that <i>Nbn</i><sup><i>mid8</i></sup> mice may provide a venue to examine the relationship between the Mre11 complex and oncogene activation in the hematopoietic compartment. Genomic analysis of <i>Nbn</i><sup><i>-/mid8vav</i></sup> malignancies showed focal amplification of 9qA2, causing overexpression of <i>MRE11</i> and <i>CHK1</i> We propose that overexpression of <i>MRE11</i> compensates for the metastable Mre11-Nbn<sup>mid8</sup> interaction, and that selective pressure for overexpression reflects the essential role of Nbn in promoting assembly and activity of the Mre11 complex.
Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte (2016)

Diabetes mellitus (DM) during pregnancy causes congenital malformation, macrosomia, respiratory distress syndrome, and other abnormalities in neonates, but whether maternal DM affects the neonatal innate immune system is unknown. Therefore we aimed to reveal the influence of DM in pregnancy on the toll-like receptor (TLR)-mediated innate immune response in neonates. Cord blood was collected after full-term vaginal or cesarean delivery and classified into a DM group (n=8) and non-DM (control) group (n=7). Mononuclear cells were harvested from cord blood by using density gradient centrifugation, after which anti-CD14 magnetic beads were used to isolate monocytes from the mononuclear population. After monocytes were cultured with lipopolysaccharide (TLR4 ligand), flagellin (TLR5 ligand), Pam3CSK4 (TLR1/TLR2 ligand), zymosan (TLR2/TLR6 ligand), or macrophage-activating lipopeptide (TLR2/TLR6 ligand) for 12h, the cytokine levels (interleukin [IL]-8, IL-6, IL-1β, IL-10, tumor necrosis factor alpha and IL-12) in the culture supernatants were measured. Compared with the control group, the DM group had higher concentrations of IL-8 (P=0.01) and tumor necrosis factor alpha (P=0.02) after monocyte cultures were stimulated with Pam3CSK4 and higher concentrations of IL-8 (P=0.01) after flagellin treatment. In contrast, stimulation with lipopolysaccharide, zymosan, or macrophage-activating lipopeptide did not lead to any difference in cytokine profiles between the two groups. These data indicate that maternal DM induces excessive inflammatory activation in neonates via a TLR5- or TLR1/2-mediated innate immune response.
Johann N. Neem, Creating a Nation of Joiners: Democracy and Civil Society in Early National Massachusetts (Cambridge, MA: Harvard University Press, 2008, £36.95/$49.95). Pp. 259. isbn978 0 674 03079 4. (2009)

Johann N. Neem, Creating a Nation of Joiners: Democracy and Civil Society in Early National Massachusetts (Cambridge, MA: Harvard University Press, 2008, £36.95/$49.95). Pp. 259. isbn978 0 674 03079 4. - Volume 43 Issue 3
Supplementary Methods from An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors (2023)

&lt;p&gt;PDF file - 27K, Antibody cross-competition studies; Alphascreen Assay to detect ERK phosphorylation.&lt;/p&gt;