gebhart/patrepeval huggingface dataset:
Clinical and Non-clinical Proof of Concept Supporting the Development of RJX As an Adjunct to Standard of Care Against Severe COVID-19 (2022)

ABSTRACT Background The identification of effective strategies capable of reducing the case mortality rate of high-risk COVID-19 is an urgent and unmet medical need. We recently reported the clinical safety profile of RJX, a well-defined intravenous GMP-grade pharmaceutical formulation of anti-oxidant and anti-inflammatory vitamins as active ingredients, in a Phase 1 study in healthy volunteers ( ClinicalTrials.gov Identifier: NCT03680105 ) (Uckun et al., Front. Pharmacol. 11, 594321. 10.3389/fphar.2020.594321). Here we report data from a pilot clinical study (RPI-015) which examined the safety, tolerability, and feasibility of using RJX in combination with clinical standard of care (SOC) in hospitalized COVID-19 patients with pneumonia ( ClinicalTrials.gov Identifier: NCT04708340 ). In addition to our early clinical proof of concept (POC) data, we also present non-clinical POC from a mouse model of CRS and ARDS that informed the design of the reported clinical study. Methods 13 patients, who were hospitalized with COVID-19 pneumonia and abnormally elevated serum inflammatory biomarkers markers ≥3 months prior to the identification of the first confirmed U.S case of the Omicron variant, were treated with IV RJX (daily x 7 days) plus SOC. Non-clinical POC study examined the ability of RJX plus dexamethasone (DEX) to improve the survival outcome in the lipopolysaccharide (LPS)-Galactosamine (GalN) mouse model of fatal cytokine release syndrome (CRS), sepsis and acute respiratory distress syndrome (ARDS). Findings In the Phase 1 clinical study, none of the 13 patients developed a treatment-related DLT, SAE, or Grade 3-5 AEs. Nine (9) of the 12 evaluable patients, including 3 patients with hypoxemic respiratory failure, showed rapid clinical recovery. In the non-clinical POC study in LPS-GalN challenged mice, the combination of RJX plus DEX was more effective than RJX alone or DEX alone, reversed the CRS as well as inflammatory tissue damage in the lungs and liver, and improved the survival outcome. Taken together, these findings provide the early clinical and non-clinical POC for the development of RJX as an adjunct to the SOC in the multi-modality management of high-risk COVID-19.
Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients (2021)

These findings support vaccination efficacy, also suggesting that vaccination likely offers more protection than natural infection.
GRIM-19 Disrupts E6/E6AP Complex to Rescue p53 and Induce Apoptosis in Cervical Cancers (2011)

The levels of GRIM-19 and p53 were concurrently down regulated in cervical cancers. The restoration of GRIM-19 can induce ubiquitination and degradation of E6AP, and disrupt the E6/E6AP complex through the interaction of N-terminus of GRIM-19 with both E6 and E6AP, which protected p53 from degradation and promoted cell apoptosis. Tumor xenograft studies also revealed the suppression of p53 degradation in presence of GRIM-19. These data suggest that GRIM-19 can block E6/E6AP complex; and synergistically suppress cervical tumor growth with p53.
FIE, a nuclear PRC2 protein, forms cytoplasmic complexes inArabidopsis thaliana (2016)

Polycomb group (PcG) proteins are evolutionarily conserved chromatin modifiers that regulate developmental pathways in plants. PcGs form nuclear multi-subunit Polycomb Repressive Complexes (PRCs). The PRC2 complex mediates gene repression via methylation of lysine 27 on histone H3, which consequently leads to chromatin condensation. In Arabidopsis thaliana, several PRC2 complexes with different compositions were identified, each controlling a particular developmental program.The core subunit FIE is crucial for PRC2 function throughout the plant life cycle, yet accurate information on its spatial and temporal localization was absent. This study focused on identifying FIE accumulation patterns, using microscopy and biochemical approaches. Analysing endogenous FIE and transgenic gFIE-green fluorescent protein fusion protein (gFIE-GFP) showed that FIE accumulates in the nuclei of every cell type examined. Interestingly, gFIE-GFP, as well as the endogenous FIE, also localized to the cytoplasm in all examined tissues. In both vegetative and reproductive organs, FIE formed cytoplasmic high-molecular-mass complexes, in parallel to the nuclear PRC2 complexes. Moreover, size-exclusion chromatography and bimolecular fluorescence complementation assays indicated that in inflorescences FIE formed a cytoplasmic complex with MEA, a PRC2 histone methyltransferase subunit. In contrast, CLF and SWN histone methyltransferases were strictly nuclear. Presence of PRC2 subunits in cytoplasmic complexes has not been previously described in plants. Our findings are in agreement with accumulating evidence demonstrating cytoplasmic localization and function of PcGs in metazoa. The cytosolic accumulation of PRC2 components in plants supports the model that PcGs have alternative non-nuclear functions that go beyond chromatin methylation.
Ultra-Broad-Band GaAs Monolithic Amplifier (1982)

GaAs monolithic IC design and fabrication techniques suitable for baseband pulse amplification have been developed. The developed GaAs monolithic amplifier has a two-stage construction using two source-grounded FET's. To reduce input VSWR without serious noise-figure degradation, an inter-gate-drain negative feedback circuit was adopted. An interstage circuit is a dc-coupled circuit consisting of an appropriate impedance transmission line. Gate voltage for the second-stage FET is self-biased. The amplifier has 13.5-dB gain over the 3-dB bandwidth from below 500 MHz to 2.8 GHz. Less than 6-dB (7-dB) noise figure was obtained from 700 MHz to 2.2 GHz (150 MHz to 3 GHz). Input VSWR is less than 1.5
Rotational Vibration of a Helical Gear Pair with Modified Tooth Surfaces. 3rd Report. Rotational Motion and Dynamic Increment of Tooth Load. (1991)

The rotational motion of a gear pair with the equivalent profile is analyzed under load. The path of contact consists of two different curves connected discontinuously. In its continuous region, equations of motion are solved and the fluctuated tooth load is calculated. At the point where it is discontinuous, the impact load is calculated from the difference of angular momentum. The dynamic incremental load on the tooth surface during one pitch can be given by a periodical function combined with the fluctuated load and the impact one, which is expressed through a Fourier series.
Electrochemical Biosensors - Ways to Improve Sensor Performance (1996)

(1996). Electrochemical Biosensors - Ways to Improve Sensor Performance. Biotechnology and Genetic Engineering Reviews: Vol. 13, No. 1, pp. 237-266.
专家视点：遵守环保法规 穿越绿色曲线 (2007)

为遵守环保法规（ERC）全球电子行业中的产品管理可能陷入混乱，这已不是秘密。从欧盟（EU）到环太平洋地区再到美洲，电子制造商正面临着复杂混乱的新法规，以及重大的商业风险。虽然有些公司希望这些新法规稍纵即逝，但是大多数公司意识到遵守环保法规已成定局。
Mid-infrared laser performance of Ce3+-doped selenide glass (2021)

An extensive study of a novel room-temperature mid-infrared Ce<sup>3+</sup>-doped Ge<sub>20</sub>Sb<sub>10</sub>Ga<sub>5</sub>Se<sub>65</sub> glass laser is reported. An influence of output-coupler transmission on laser efficiency and emission spectra is investigated. Pumped by a pulsed Fe:ZnSe laser at 4.1 µm, a maximum output energy of 35 mJ is demonstrated at 5.2 µm, with a laser threshold of about 60 mJ and a slope efficiency of 21%. The tuning range of a mid-infrared Ce:glass laser is reported for the first time: with an intracavity prism, the laser is continuously tunable in the spectral range of 4.5-5.6 µm. The internal losses are determined to be below 9% per roundtrip.
Factors affecting the stability of viral vaccines. (1996)

The stability of viral vaccines is determined by the rate of loss of "integrity" of the viral antigen during storage. For live vaccines, such as measles, mumps, rubella, canine distemper, stability is equivalent to the preservation of the infectious titres. For inactivated and subunit vaccines, the preservation of the antigenic structure and the correct steric presentation of the relevant epitopes are the parameters which determine their stability. In general, the following factors may have a negative effect on stability: temperature, pH outside the physiological limits, organic solvents, repeated freezing and thawing, some antiseptics and inactivating agents, and light. However their negative effect is in most cases specific for the individual viruses. Approaches to stabilisation of most vaccines are based on the elimination or neutralisation of the negative factors. Practical examples for the most relevant existing vaccines are described.
Cryoetching mechanisms and STiGer process evaluation (2016)

International audience
Uncontrolled polymerization that occurred during photoinitiated RAFT dispersion polymerization of acrylic monomers promotes the formation of uniform raspberry-like polymer particles (2020)

Uniform raspberry-like polymer particles are prepared by a different type of photoinitiated RAFT dispersion polymerization.
Abstract A75: Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: Biotransformation, chemical synthesis and biological evaluation (2012)

Abstract It is now well accepted that natural compounds provide the opportunity to interfere in early stages of cancer or prevent its development altogether. However, these types of compounds do have their limitations, such as short half-life and fast metabolism once ingested. Often, presence of the compound can only be assessed by quantification of metabolites, suggesting that these metabolites circulate in the body for a certain amount of time and potentially interact with biological processes. In the present study, we investigated the biotransformation of [6]-shogaol, a bioactive component in ginger (Zingiber officinale Rosc.), in cancer cells, mice and humans. Our results indicated that [6]-shogaol is extensively metabolized in cancer cells and in vivo. To further investigate whether these metabolites retain bioactivity, we synthesized the major metabolites of [6]-shogaol and evaluate their anti-cancer activities. Twelve metabolites of [6]-shogaol (M1, M2, and M4-M13) were successfully synthesized using simple and easily accessible chemical methods. Growth inhibition assays showed most metabolites of [6]-shogaol had measurable activities against human cancer cells HCT-116 and H-1299. In particular, metabolite M2 greatly retained the biological activities of [6]-shogaol. The toxicity evaluation of the synthetic metabolites (M1, M2, and M4-M13) against human normal fibroblast colon cells CCD-18Co and human normal lung cells IMR-90 demonstrated a detoxifying metabolic biotransformation of [6]-shogaol. The most active metabolite M2 had almost no toxicity to CCD-18Co and IMR-90 normal cells. TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay indicated apoptosis was triggered by metabolites M2, M13, and its two diastereomers M13-1 and M13-2. There was no significant difference between the apoptotic effect of [6]-shogaol and those of M2 and M13 at 6 hour time point treatment. (This project is supported by NIH grants CA138277 and CA138277-S1 to S. Sang). Citation Format: Huadong Chen, Yingdong Zhu, Dominique Soroka, Renaud Warin, Shengmin Sang. Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: Biotransformation, chemical synthesis, and biological evaluation. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr A75.
Distortion-Product Otoacoustic Emissions in (1992)

Cubic distortion-product otoacoustic emissions (DPEs) may have clinical and research applications. We reliably recorded DPEs at some frequencies in all of the normal-hearing human adults and newborns tested. Adult and newborn DPEs were of comparable amplitude, with the exception that a prominent dip between 1 and 3 kHz in the adult data was less evident in the newborn data. DPE amplitude was a linear function of the intensity of the eliciting primary stimuli. The slopes of the linear input-output functions increased with increasing frequency. Except at the highest frequencies assessed, adult input-output functions were steeper than newborn input-output functions.
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair? (2012)

Tendon injuries represent even today a challenge as repair may be exceedingly slow and incomplete. Regenerative medicine and stem cell technology have shown to be of great promise. Here, we will review the current knowledge on the mechanisms of the regenerative potential of mesenchymal stem cells (MSCs) obtained from different sources (bone marrow, fat, cord blood, placenta). More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. Based on the recently emerging role in regenerative mechanisms of soluble factors and of extracellular vesicles, we will discuss the potential of non-cellular therapies in horse tendon injuries.
Process and Device Performance of Submicrometer-Channel CMOS Devices Using Deep-Trench Isolation and Self-Aligned TiSi/sub 2/ Technologies (1985)

According to our scaling study, a deeper n-well allows for a lower n-well surface concentration with improved short-channel effects in submicrometer-channel PMOS-FET's. The deep n-well, however, requires a large space between n- and p-channel devices. This large space limits the integration density in scaled bulk CMOS VLSI's. The deep-trench isolation combined with an epitaxial layer resolves this drawback with significantly improved device-to-device isolation and latchup susceptibility. The 6-/spl mu/m-deep with 2-/spl mu/m-wide deep trench is etched in the epitaxial layer and is refilled with 1500 /spl Aring/ of thermal silicon-dioxide film and 2/spl mu/m of polysilicon film. The sheet resistances of N/sup +/ and P/sup +/ diffusion and N/sup +/ -doped polysilicon layers were reduced to 3 to 4 /spl Omega//spl square/ by using the self-aligned TiSi/sub 2/ layer with an oxide sidewall spacer. As a result of this low sheet resistance, the saturation drain current of submicrometer n- and p-channel MOSFET's was improved approximately 33 to 37 percent compared with conventional MOSFET's without the self-aligned TiSi/sub 2/ layer. The 0.5-/spl mu/m-channel CMOS devices using the deep-trench isolation with an epitaxial layer and the self-aligned TiSi/sub 2/ layer operated at a propagation delay time of 140 ps with a power dissipation of 1.1 mW per inverter and attained a maximum clock frequency of 400 MHz in a static /spl divide/ 4 counter without suffering from Iatchup even at the Iatchup trigger current of 200 mA.
Membrane-less organic–inorganic aqueous flow batteries with improved cell potential (2016)

A membrane-less organic-inorganic flow battery based on zinc and quinone species is proposed. By virtue of the slow dissolution rate of the deposited anode (<11.5 mg h<sup>-1</sup> cm<sup>-2</sup>), the battery has a cell voltage of ca. 1.52 V with an average energy efficiency of ca. 73% at 30 mA cm<sup>-2</sup> over 12 cycles.
Probabilistic models for personalizing web search (2012)

We present a new approach for personalizing Web search results to a specific user. Ranking functions for Web search engines are typically trained by machine learning algorithms using either direct human relevance judgments or indirect judgments obtained from click-through data from millions of users. The rankings are thus optimized to this generic population of users, not to any specific user. We propose a generative model of relevance which can be used to infer the relevance of a document to a specific user for a search query. The user-specific parameters of this generative model constitute a compact user profile. We show how to learn these profiles from a user's long-term search history. Our algorithm for computing the personalized ranking is simple and has little computational overhead. We evaluate our personalization approach using historical search data from thousands of users of a major Web search engine. Our findings demonstrate gains in retrieval performance for queries with high ambiguity, with particularly large improvements for acronym queries.
Adaption of an in vitro digestion method to screen carotenoid liberation and in vitro accessibility from differently processed spinach preparations (2016)

Dark green leafy vegetables are primary food sources for lutein and β-carotene, however these bioactives have low bioavailability. The effects of mechanical and thermal processing as well as fat addition and fat type on lutein and β-carotene liberation and in vitro accessibility from spinach were investigated. Lutein liberation and in vitro accessibility were three-fold higher from spinach puree compared to whole leaves. Results for β-carotene liberation were similar, whereas that of β-carotene accessibility was only about two-fold. Steaming had no or a negative effect on carotenoid liberation. Fat addition increased β-carotene liberation from raw and steamed puree, but reduced lutein liberation from steamed leaves and raw puree. Fat types affected β-carotene differently. Butter addition led to a 2.5 fold increased liberation from raw spinach puree, while the effect of olive and peanut oil was significantly lower, but only minor effects were observed for lutein.
<title>Transurethral canine prostatectomy with a cylindrically diffusing fiber</title> (1994)

In this study, visual laser ablation of the prostate (VLAP) was performed on eight mongrel dogs utilizing a cylindrically diffusing fiber attached to a 1.06 neodymium:YAG (Nd:YAG) laser. All dogs received one continuous dose totaling 15,000 J (25 W for 10 min) applied from the vesical neck to the colliculus seminalis. There was no visible hemorrhage from the lasing intraoperatively in any dog. Postoperative recovery was uneventful with no dog experiencing urinary incontinence and only one incident of dysuria with urinary retention during their observation period. Gross and histopathologic examinations of serial sections of the prostate were performed from 2 hours to 7 weeks postoperatively and demonstrated a consistent spherical zone of destruction 2.9 cm (average) in diameter. We believe the simplified fiber placement and complete lack of postoperative complications in this small group of dogs suggest that the cylindrically diffusing fiber offers significant advantage over laterally deflecting fibers for transurethral prostatectomies in the dog.
Single-factor Hensel lifting and its application to the straight-line complexity of certain polynomials (1987)

Three theorems are presented that establish polynomial straight-line complexity for certain operations on polynomials given by straight-line programs of unbounded input degree. The first theorem shows how to compute a higher order partial derivative in a single variable. The other two theorems impose the degree of the output polynomial as a parameter of the length of the output program. First it is shown that if a straight-line program computes an arbitrary power of a multivariate polynomial, that polynomial also admits a polynomial bounded straight-line computation. Second, any factor of a multivariate polynomial given by a division-free straight-line program with relatively prime co-factor also admits a straight-line computation of length polynomial in the input length and the degree of the factor. This result is based on a new Hensel lifting process, one where only one factor image is lifted back to the original factor. As an application we get that the greatest common divisor of polynomials given by a division-free straight-line program has polynomial straight-line complexity in terms of the input length and its own degree.
CREB-Binding Protein Modulates Repeat Instability in a Drosophila Model for PolyQ Disease (2007)

Although expansion of trinucleotide repeats accounts for over 30 human diseases, mechanisms of repeat instability remain poorly understood. We show that a Drosophila model for the CAG/polyglutamine (polyQ) disease spinocerebellar ataxia type 3 recapitulates key features of human CAG-repeat instability, including large repeat changes and strong expansion bias. Instability is dramatically enhanced by transcription and modulated by nuclear excision repair and a regulator of DNA repair adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein-a histone acetyltransferase (HAT) whose decreased activity contributes to polyQ disease. Pharmacological treatment to normalize acetylation suppressed instability. Thus, toxic consequences of pathogenic polyQ protein may include enhancing repeat instability.
Symphyseal distention in relation to serum relaxin levels and pelvic pain in pregnancy (2000)

Severe pelvic pain during pregnancy was strongly associated with an increased symphyseal distention. However, the severity of pain did not predict the degree of symphyseal distention in the individual case, indicating that other mechanisms are also involved. Serum relaxin levels were not associated with the degree of symphyseal distention or with pelvic pain in pregnancy.
Ultra-compact waveguide devices in thin film lithium niobate (2015)

International audience
Data-driven generation of plausible tissue geometries for realistic photoacoustic image synthesis. (2021)

Photoacoustic tomography (PAT) has the potential to recover morphological and functional tissue properties such as blood oxygenation with high spatial resolution and in an interventional setting. However, decades of research invested in solving the inverse problem of recovering clinically relevant tissue properties from spectral measurements have failed to produce solutions that can quantify tissue parameters robustly in a clinical setting. Previous attempts to address the limitations of model-based approaches with machine were hampered by the absence of labeled reference data needed for supervised algorithm training. While this bottleneck has been tackled by simulating training data, the domain gap between real and simulated images remains a huge unsolved challenge. As a first step to address this bottleneck, we propose a novel approach to PAT data simulation, which we refer to as learning to simulate. Our approach involves subdividing the challenge of generating plausible simulations into two disjoint problems: (1) Probabilistic generation of realistic tissue morphology, represented by semantic segmentation maps and (2) pixel-wise assignment of corresponding optical and acoustic properties. In the present work, we focus on the first challenge. Specifically, we leverage the concept of Generative Adversarial Networks (GANs) trained on semantically annotated medical imaging data to generate plausible tissue geometries. According to an initial in silico feasibility study our approach is well-suited for contributing to realistic PAT image synthesis and could thus become a fundamental step for deep learning-based quantitative PAT.