gebhart/patrepeval huggingface dataset:
Quantum Annealing Based Binary Compressive Sensing with Matrix Uncertainty (2019)

Compressive sensing is a novel approach that linearly samples sparse or compressible signals at a rate much below the Nyquist-Shannon sampling rate and outperforms traditional signal processing techniques in acquiring and reconstructing such signals. Compressive sensing with matrix uncertainty is an extension of the standard compressive sensing problem that appears in various applications including but not limited to cognitive radio sensing, calibration of the antenna, and deconvolution. The original problem of compressive sensing is NP-hard so the traditional techniques, such as convex and nonconvex relaxations and greedy algorithms, apply stringent constraints on the measurement matrix to indirectly handle this problem in the realm of classical computing. We propose well-posed approaches for both binary compressive sensing and binary compressive sensing with matrix uncertainty problems that are tractable by quantum annealers. Our approach formulates an Ising model whose ground state represents a sparse solution for the binary compressive sensing problem and then employs an alternating minimization scheme to tackle the binary compressive sensing with matrix uncertainty problem. This setting only requires the solution uniqueness of the considered problem to have a successful recovery process, and therefore the required conditions on the measurement matrix are notably looser. As a proof of concept, we can demonstrate the applicability of the proposed approach on the D-Wave quantum annealers; however, we can adapt our method to employ other modern computing phenomena -like adiabatic quantum computers (in general), CMOS annealers, optical parametric oscillators, and neuromorphic computing.
Add-On Therapy in Epilepsy with Calcium Entry Blockers (1986)

In view of the known role of Ca2+ in the paroxysmal depolarization shifts of epileptic neurones, the possibility arises that certain Ca2+ entry blockers possess antiepileptic activity. The only drug of the class which readily passes the blood-brain barrier is flunarizine. This is effective in experimental models of epilepsy and produced significant seizure reduction in two therapeutic trials in therapy-resistant patients. It has few and mild side effects at therapeutic blood levels.
Network Coding-Aware Multipath Routing in Multi-Hop Wireless Networks (2011)

Abstract: This paper proposes a network coding-aware multi-path routing (CAMP) protocol, which forwards packets over multiple paths dynamically based on path reliability and coding opportunity. CAMP employs a route discovery mechanism which returns to the source multiple paths along with ETX (expected transmission count) of all links on each path. With its unique forwarding mechanism, CAMP splits the traffic among multiple paths and actively creates, while not merely waiting for, the coding opportunity by switching its path to maximize the switching gain and thus improves the network throughput. The experimental results demonstrate that CAMP can achieve much higher throughput than peer schemes for delivering packets in wireless networks.
Clinical relevance of major allergens compared to extract-based IgE diagnosis in pollen-allergic patients in Austria (2022)

Background: Pollen-allergy is common in Austria. The present study investigated if the use of major pollen-allergens on top of extract-based diagnosis may improve the diagnostic accuracy and if this additional knowledge helps to identify patients eligible for allergen-specific immunotherapy (AIT). Methods: In this retrospective database analysis patients sensitized to a grass, birch, ash-tree, mugwort or ragweed were investigated and results of pollen extracts compared to the respective major allergens (Phl p 1, Bet v 1, Ole e 1, Art v 1, Amb a 1) were assessed. Furthermore, extract- and MD- results of patients double-sensitized to both tree-extracts or both weed-extracts were compared. In patients with discrepant results, their charts were reviewed to define if this difference was clinically relevant in regard to their doctors´ AIT-decision. Results: 4234 patients (age 1.2-89.7yrs) could be included in the analyses. There was high agreement between extract-based IgE results and major allergens concerning single-sensitization to grass/Phl p 1+5 (94.4%), birch/Bet v 1 (94.4%), and ash-tree/Ole e 1 (82.9%), with lower agreement between mugwort/Art v 1 (64.1%) and ragweed/Amb a 1 (73.8%). Among patients double-sensitized to both tree pollen extracts only 76% were also sensitized to both major allergens (Bet v 1 and Ole e 1) and therefore suitable for AIT. In patients double-sensitized to both weeds, only 25% were also sensitized to both major allergens (Art v 1 and Amb a 1), 46.2% of mugwort extract positive patients tested negative for Art v 1. Of these patients, 41.3% were recommended a ragweed AIT as their Amb a 1 results were positive. Conclusion: MD can improve diagnostic accuracy in patients with pollen-allergy and should be implemented in standard clinical care, especially when double-sensitization to allergens of plants with overlapping pollen seasons cannot be clearly discerned by patients´ symptoms alone.
Fractional optical vortex creates a curved "spin-jet" (2020)

We discover an entirely novel phenomenon, so-called the formation of curved “spin-jet”, in which an irradiated fractional optical vortex provides a donor film non-axisymmetric torque to form a “spin-jet” with a curved trajectory. This phenomenon allows the development of a novel pattering technology to scan the ejected donor dots without any mechanical systems.
Insights into the Eco-Friendly Adsorption of Caffeine from Contaminated Solutions by Using Hydrogel Beads (2015)

The presence of drugstore products in water streams has become a major concern in environmental remediation. Preliminary studies have reported that caffeine has negative impacts in animals and ecology in general. Bioremediation emphasizes on the elimination of heavy metals and toxic organic pollutants, but little attention has been paid to the so-called pollutants of emerging concern (i.e. caffeine). This research evaluates the role of pH, adsorbent dose, salinity and time on the elimination of caffeine from aqueous solutions by using chitosan and alginate hydrogel beads. Experimental data indicates a strong pH effect on the adsorption, showing its highest values around neutral conditions. On the other hand, salinity has a negative effect on the adsorption, due to competition for the adsorption sites of both hydrogels. Finally, time dependence experiments demonstrate that less than 20 minutes are needed to reach adsorption equilibrium. These results suggest that biodegradable and cost-effective materials are good candidates for the removal of pollutants of emerging concern from contaminated waters.
Allogeneic hematopoietic cell transplantation in acute myeloid leukemia with intermediate-risk - results of the randomized ETAL-1 trial (2022)

Abstract The ideal post-remission strategy in patients with intermediate-risk (IR) acute myeloid leukemia (AML) in first complete remission (CR) has been a matter of debate. To address this question, one hundred and forty-three patients with AML, IR cytogenetics in first CR or CRi, aged ≤ 60 years with an available HLA-matched sibling or unrelated donor were randomized 1:1 to either receive allogeneic HCT or high-dose cytarabine for consolidation and salvage HCT only in case of relapse. According to the intent-to-treat analysis, the probability of survival at 2 years was 71% (95%-CI 60-81%) and 84% (95%.CI 73-92%) in Arm A (Primary allogeneic HCT) and Arm B (Chemo-consolidation), respectively ( p =.120). Disease-free survival after HCT in CR1 at 2 years was 69% (95%-CI 57-80%) compared to 41% (95%-CI 29-54%; p =.001). The cumulative incidence of relapse was 20% (95% CI 13-31%) and 57% (95%-CI 46-71%; p &lt;.001), respectively. Non-relapse mortality at 2 years after primary allogeneic HCT was below 10% in both arms. No significant differences in health-related quality of life measures were observed. In summary, delayed allogeneic HCT in case of relapse may be a reasonable approach to patients ≤ 60 years of age with intermediate-risk AML in CR1 with an available donor.
Estimation of the Origin-Destination Matrix for Trucks That Use Highways: A Case Study in Chile (2022)

Nowadays, freight transport is crucial in the functioning of cities worldwide. To dig further into the understanding of urban freight transport movements, in this research, we conducted a case study in which we estimated an origin-destination matrix for the trucks traveling on Autopista Central, one of Santiago de Chile’s most important urban highways. To do so, we used full real-world vehicle-by-vehicle information of freight vehicles’ movements along the highway. This data was collected from several toll collection gates equipped with free-flow and automatic vehicle identification technology. However, this data did not include any vehicle information before or after using the highway. To estimate the origins and destinations of these trips, we proposed a multisource methodology that used GPS information provided by SimpliRoute, a Chilean routing company. Nevertheless, this GPS data involved only a small subset of trucks that used the highway. In order to reduce the bias, we built a decision tree model for estimating the trips’ origin, whose input data was complemented by other public databases. Furthermore, we computed trip destinations using proportionality factors obtained from SimpliRoute data. Our results showed that most of the estimated origins belonged to outskirt municipalities, while the estimated destinations were mainly located in the downtown area. Our findings might help improve freight transport comprehension in the city, enabling the implementation of focused transport policies and investments to help mitigate negative externalities, such as congestion and pollution.
<title>Fabrication of a single- to dual-mode fiber coupler for realizing two-mode fiber sensors</title> (1999)

We report here the fabrication of a single to dual mode evanescent field directional coupler for the first time. Experimental results are presented to show that such a coupler can be used to couple light into or to take out energy from the two modes of a two mode fiber (TMF) through a single-mode fiber (SMF). Such a coupler should be useful in the practical implementation of a two-mode fiber sensor making it compatible with the single mode fiber networks.
Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production From a Nox1-Based NADPH Oxidase (2004)

Atherosclerosis is an inflammatory disease occurring preferentially in arterial regions exposed to disturbed flow conditions including oscillatory shear stress (OS). OS exposure induces endothelial expression of bone morphogenic protein 4 (BMP4), which in turn may activate intercellular adhesion molecule-1 (ICAM-1) expression and monocyte adhesion. OS is also known to induce monocyte adhesion by producing reactive oxygen species (ROS) from reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, raising the possibility that BMP4 may stimulate the inflammatory response by ROS-dependent mechanisms. Here we show that ROS scavengers blocked ICAM-1 expression and monocyte adhesion induced by BMP4 or OS in endothelial cells (ECs). Similar to OS, BMP4 stimulated H2O2 and O2- production in ECs. Next, we used ECs obtained from p47phox-/- mice (MAE-p47-/-), which do not produce ROS in response to OS, to determine the role of NADPH oxidases. Similar to OS, BMP4 failed to induce monocyte adhesion in MAE-p47-/-, but it was restored when the cells were transfected with p47phox plasmid. Moreover, OS-induced O2- production was blocked by noggin (a BMP antagonist), suggesting a role for BMP. Furthermore, OS increased gp91phox (nox2) and nox1 mRNA levels while decreasing nox4. In contrast, BMP4 induced nox1 mRNA expression, whereas nox2 and nox4 were decreased or not affected, respectively. Also, OS-induced monocyte adhesion was blocked by knocking down nox1 with the small interfering RNA (siRNA). Finally, BMP4 siRNA inhibited OS-induced ROS production and monocyte adhesion. Together, these results suggest that BMP4 produced in ECs by OS stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step.
Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling (2002)

Syndecan-4 is a ubiquitous transmembrane proteoglycan that localizes to the focal adhesions of adherent cells and binds to a range of extracellular ligands, including growth factors and extracellular-matrix proteins. Engagement of syndecan-4 is essential for adhesion formation in cells adhering via certain integrins, and for cell proliferation and migration in response to growth factors. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. PDZ domain-containing scaffold proteins (syntenin and CASK) bind to the C-terminus of the syndecan-4 cytoplasmic domain and co-ordinate clustering of receptors and connection to the actin cytoskeleton. Syndecan-4 also binds and activates protein kinase Calpha in the presence of phosphatidylinositol 4,5-bisphosphate, and regulates signalling by Rho-family GTPases and focal adhesion kinase. This review discusses the cytoplasmic interactions of syndecan-4 and how they affect cell behaviour as a consequence of the interaction with extracellular ligands. These conclusions also offer an insight into the role of syndecan-4 in vivo, and are consistent with phenotypes generated as a consequence of abnormal syndecan-4 expression in pathologies and gene disruption studies.
Prandtl–Blasius temperature and velocity boundary-layer profiles in turbulent Rayleigh–Bénard convection (2010)

The shapes of the velocity and temperature profiles near the horizontal conducting plates' centre regions in turbulent Rayleigh–Bénard convection are studied numerically and experimentally over the Rayleigh number range 10 8 ≲ Ra ≲ 3 × 10 11 and the Prandtl number range 0.7 ≲ Pr ≲ 5.4. The results show that both the temperature and velocity profiles agree well with the classical Prandtl–Blasius (PB) laminar boundary-layer profiles, if they are re-sampled in the respective dynamical reference frames that fluctuate with the instantaneous thermal and velocity boundary-layer thicknesses. The study further shows that the PB boundary layer in turbulent thermal convection not only holds in a time-averaged sense, but is most of the time also valid in an instantaneous sense.
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease (2020)

Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chronic kidney disease (CKD). However, it seems to play a pathogenic role in the progression of renal diseases. There has been increasing focus on the link between hyperuricemia and CKD. The results of randomized controlled trials have implied independent associations between hyperuricemia and the progression of cardiovascular and renal morbidities. These associations may be mediated by renin-angiotensin system activation, nitric oxide synthase inhibition, and macrovascular/microvascular disease development. There remains controversy regarding the use of serum UA level as an indirect index of renal vascular disease. This literature review focuses on the role of asymptomatic hyperuricemia in the progression of CKD, as well as the association between hyperuricemia and cardiovascular disease. It also provides a general overview of the physiological metabolism of UA.
Tilted Fiber Bragg Grating for Chirped Microwave Waveform Generation (2010)

A tilted fiber Bragg grating (TFBG) as an optical spectral shaper to generate a chirped microwave waveform in a spectral-shaping and wavelength-to-time (SS-WTT) mapping system is proposed and demonstrated. The key component in the system is the TFBG, which has multiple resonant peaks with linearly increasing spacing in its transmission spectrum. By incorporating a TFBG into an SS-WTT system, a chirped microwave waveform is generated with the chirp rate determined by the tilt angle of the TFBG. A proof-of-concept experiment is carried out. Two TFBGs with tilt angles of 10 and 4 are fabricated and employed to generate two chirped microwave waveforms with chirp rates of 0.00700 and 0.05956 GHz/ps, respectively.
Chemical synthesis of branched RNAs: a new method for construction of synthetic units for branched RNAs by use of 2'-phosphorylation on the basis of steric control. (1991)

A 3',5'-unprotected 2'-O-bis(tert-butoxy)-phosphinyl-6-N-benzoyladenosine derivative was prepared as a key intermediate for the synthesis of branched RNAs, and used for construction of building units from which chain elongation in any of 2'-, 3'-, and 5'-directions would be possible. From this synthetic intermediate, 2'-phosphorylated ApC dimer was also synthesized.
Effect of Ofatumumab on Serum Immunoglobulin Levels and Infection Risk in Relapsing Multiple Sclerosis (RMS) Patients from the Phase 3 ASCLEPIOS I and II Trials (1300) (2021)

To determine serum immunoglobulin (Ig) levels and investigate associations between IgG/IgM levels and infection risk in ofatumumab-treated patients.
Pickering Stabilized Miniemulsion Polymerization:  Preparation of Clay Armored Latexes (2005)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPickering Stabilized Miniemulsion Polymerization: Preparation of Clay Armored LatexesSéverine Cauvin, Patrick J. Colver, and Stefan A. F. BonView Author Information Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK Cite this: Macromolecules 2005, 38, 19, 7887–7889Publication Date (Web):August 26, 2005Publication History Received25 May 2005Revised12 August 2005Published online26 August 2005Published inissue 1 September 2005https://doi.org/10.1021/ma051070zCopyright © 2005 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3235Altmetric-Citations240LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (134 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Clay,Emulsions,Lipids,Liquids,Nanoparticles Get e-Alerts
The FHA domain mediates phosphoprotein interactions (2000)

The forkhead-associated (FHA) domain is a phosphopeptide-binding domain first identified in a group of forkhead transcription factors but is present in a wide variety of proteins from both prokaryotes and eukaryotes. In yeast and human, many proteins containing an FHA domain are found in the nucleus and involved in DNA repair, cell cycle arrest, or pre-mRNA processing. In plants, the FHA domain is part of a protein that is localized to the plasma membrane and participates in the regulation of receptor-like protein kinase signaling pathways. Recent studies show that a functional FHA domain consists of 120-140 amino acid residues, which is significantly larger than the sequence motif first described. Although FHA domains do not exhibit extensive sequence similarity, they share similar secondary and tertiary structures, featuring a sandwich of two anti-parallel (beta)-sheets. One intriguing finding is that FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine, distinguishing them from other well-studied phosphoprotein-binding domains. The diversity of proteins containing FHA domains and potential differences in binding specificities suggest the FHA domain is involved in coordinating diverse cellular processes.
Structural gate decomposition for depth-optimal technology mapping in LUT-based FPGA design (1996)

In this paper, we study the problem of decomposing gates in fanin-unbounded or K-bounded networks such that the K-input LUT mapping solutions computed by a depthoptimal mapper have minimum depth. We show (1) any decomposition leads to a smaller or equal mapping depth regardless the decomposition algorithm used, and (2) the problem is NP-hard for unbounded networks when K 3 and remains NP-hard for K-bounded networks when K 5. We propose a gate decomposition algorithm, named DOGMA, which combines level-driven node packing technique (Chortle-d) and the network flow based optimal labeling technique (FlowMap). Experimental results show that networks decomposed by DOGMA allow depthoptimal technology mappers to improve the mapping solutions by up to 11% in depth and up to 35% in area comparing to the mapping results of networks decomposed by other existing decomposition algorithms.
Linear and Circular Polarization Filters Using Sculptured Thin Films (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Ian Hodgkinson, Qi Hong Wu, Akhlesh Lakhtakia, and Russell Messier, "Linear and Circular Polarization Filters Using Sculptured Thin Films," Optics & Photonics News 10(12), 30-31 (1999) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Canadian Galactic Plane Survey - Phase 2. (1999)

Subgingival irrigation with propolis extract as an adjuvant to periodontal treatment was more effective than conventional treatment both by clinical and microbiological parameters.
Dilated U-net based approach for multichannel speech enhancement from First-Order Ambisonics recordings (2020)

We present a CNN architecture for speech enhancement from multichannel first-order Ambisonics mixtures. The data-dependent spatial filters, deduced from a mask-based approach, are used to help an automatic speech recognition engine to face adverse conditions of reverberation and competitive speakers. The mask predictions are provided by a neural network, fed with rough estimations of speech and noise amplitude spectra, under the assumption of known directions of arrival. This study evaluates the replacing of the recurrent LSTM network previously investigated by a convolutive U-net under more stressing conditions with an additional second competitive speaker. We show that, due to more accurate short-term masks prediction, the U-net architecture brings some improvements in terms of word error rate. Moreover, results indicate that the use of dilated convolutive layers is beneficial in difficult situations with two interfering speakers, and/or where the target and interferences are close to each other in terms of the angular distance. Moreover, these results come with a two-fold reduction in the number of parameters.