gebhart/patrepeval huggingface dataset:
Catálogo razonado de castillos y fortalezas de la provincia de Valencia (2011)

En el ano 2010 la UPV concedio una ayuda para el proyecto de investigacion titulado: “Catalogo razonado de castillos y fortalezas de la provincia de Valencia”. Ha sido desarrollado durante 18 meses1. 
El objetivo principal era el inventariado de todos los castillos existentes en la provincia, recopilando datos relativos a su localizacion, estado juridico, descripcion, analisis de las estructuras, materiales, estado de conservacion y, en su caso, levantamiento de planos. Estos datos han sido introducidos en una ficha tipo 
que puede ser consultada a traves de una aplicacion SIG (Sistema de informacion geografica). 
Se han catalogado un total de 87 castillos, de los cuales 45 disponen de levantamientos de planos. 
La aplicacion permite realizar consultas relativas a cualquiera de los campos introducidos en la ficha, lo que ha facilitado la elaboracion de conclusiones 
directamente aplicadas a la conservacion de estos monumentos.
Electrical characterization of SiO2(Si) films as a medium for charge storage (2008)

Abstract At present, the nonvolatile memory devices based on different kinds of nanocrystals are intensively developed. The important problem for further progress is connected with the optimization of gate multilayer structure. The aim of this work is the investigation of the electrical properties of thin nanocomposite SiO 2 (Si) films as a medium for the charge storage. The silicon enriched SiO x films were deposited by plasma enhanced chemical vapor deposition (PE CVD) method. The film composition was controlled changing the ratio of the flows of reactive gases SiH 4 and N 2 O in a vacuum chamber. Subsequent thermal annealing led to the phase separation in SiO x films with a formation of nanocomposite SiO 2 (Si) structure of Si nanocrystals in dielectric matrix. Capacity‐voltage and current‐voltage measurements of MIS structures with gate nanocomposite SiO 2 (Si) films allowed to optimize the technological conditions of the formation of MIS structures with good charge storage properties. The value and the sign of stored charge were determined from the shift of C‐V characteristics. Analysis of the C‐V characteristics of MIS structures with nanocomposite SiO 2 (Si) films used equivalent circuit with the capacity of nanocrystals connected in parallel to the capacity of dielectric. The decrease of capacity in the accumulation region caused by nanocrystals was observed. The mechanism of current transport through the SiO 2 (Si) films was analyzed. It is determined to occur by tunneling through the SiO 2 layers between the Si nanocrystals. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
THE CONVERSION OF FIBRINOGEN TO FIBRIN (1953)

1. Fibrin clots prepared in the absence of calcium can be dissolved in solutions of lithium chloride and bromide and sodium bromide and iodide, as well as of guanidine hydrochloride and urea. These salts do not denature fibrinogen under the same conditions of concentration, temperature, and time. Sedimentation experiments on the fibrin solutions show in each case a single sharp peak with a sedimentation constant close to that of fibrinogen. 2. At lower concentrations, these salts inhibit the clotting of fibrinogen by thrombin, but in the case of lithium bromide and sodium iodide, at least, allow an intermediate polymer to accumulate whose sedimentation constant is close to that of the polymer observed in systems inhibited by hexamethylene glycol or urea.
Phase reference for the generalized multichannel Wiener filter (2016)

The multichannel Wiener filter (MWF) is a well-established noise reduction technique for speech processing. Most commonly, the speech component in a selected reference microphone is estimated. The choice of this reference microphone influences the broadband output signal-to-noise ratio (SNR) as well as the speech distortion. Recently, a generalized formulation for the MWF (G-MWF) was proposed that uses a weighted sum of the individual transfer functions from the speaker to the microphones to form a better speech reference resulting in an improved broadband output SNR. For the MWF, the influence of the phase reference is often neglected, because it has no impact on the narrow-band output SNR. The G-MWF allows an arbitrary choice of the phase reference especially in the context of spatially distributed microphones. In this work, we demonstrate that the phase reference determines the overall transfer function and hence has an impact on both the speech distortion and the broadband output SNR. We propose two speech references that achieve a better signal-to-reverberation ratio (SRR) and an improvement in the broadband output SNR. Both proposed references are based on the phase of a delay-and-sum beamformer. Hence, the time-difference-of-arrival (TDOA) of the speech source is required to align the signals. The different techniques are compared in terms of SRR and SNR performance.
Prenatal microRNA miR-200b Therapy Improves Nitrofen-induced Pulmonary Hypoplasia Associated With Congenital Diaphragmatic Hernia (2017)

Our data indicate that miR-200b improves PH and decreases the incidence of CDH. Future studies will further exploit this newly discovered prenatal therapy for lung hypoplasia and CDH.
Overcoming Information Overload in the Enterprise: The Active Approach (2010)

Knowledge workers are central to an organization's success, yet their information management tools often hamper their productivity. This has major implications for businesses across the globe because their commercial advantage relies on the optimal exploitation of their own enterprise information, the huge volumes of online information, and the productivity of the required knowledge work. The Active project addresses this challenge through an integrated knowledge management workspace that reduces information overload by significantly improving the mechanisms for creating, managing, and using information. The project's approach follows three themes: sharing information through tagging, wikis, and ontologies; prioritizing information delivery by understanding users' current-task context; and leveraging informal processes that are learned from user behavior.
Collaborative Filtering: A Machine Learning Perspective (2004)

Collaborative filtering was initially proposed as a framework for filtering information based on the preferences of users, and has since been refined in many different ways. This thesis is a comprehensive study of rating-based, pure, non-sequential collaborative filtering. We analyze existing methods for the task of rating prediction from a machine learning perspective. We show that many existing methods proposed for this task are simple applications or modi cations of one or more standard machine learning methods for classifi cation, regression, clustering, dimensionality reduction, and density estimation. We introduce new prediction methods in all of these classes. We introduce a new experimental procedure for testing stronger forms of generalization than has been used previously. We implement a total of nine prediction methods, and conduct large scale prediction accuracy experiments. We show interesting new results on the relative performance of these methods.
The Mobile Application Environment (2008)

This chapter contains sections titled: The Mobile Web Architecture Mobile Browser Mobile Content Data Formats Multiple Interaction Modalities and Devices Summary
ChemInform Abstract: An Improved Synthetic Route to Huperzine A. New Analogues and Their Inhibition of Acetylcholinesterase. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Overall survival (OS) in patients (pts) with advanced breast cancer (ABC) with visceral metastases (mets), including those with liver mets, treated with ribociclib (RIB) plus endocrine therapy (ET) in the MONALEESA (ML) -3 and -7 trials. (2020)

1054 Background: In the Phase III ML-3 (NCT02422615) and ML-7 (NCT02278120) trials, RIB + ET demonstrated a significant OS benefit (ML-3: HR, 0.72, P = 0.00455; ML-7: HR, 0.71, P = 0.00973) over placebo (PBO) + ET in pts with HR+/HER2- ABC (Im et al. N Engl J Med. 2019; Slamon et al. N Engl J Med. 2019). The presence of visceral mets generally portends a poor prognosis, which is especially poor in pts with liver mets (He et al. Ann Oncol. 2019). Here we report OS in pts with visceral mets with a focus on those with liver mets in ML-3 and ML-7. Methods: In ML-3, postmenopausal pts were randomized 2:1 to receive RIB + fulvestrant (FUL) or PBO + FUL as first- (1L) or second-line (2L) treatment. In ML-7, premenopausal pts were randomized 1:1 to receive RIB + ET or PBO + ET (this analysis included only pts who received an NSAI as ET partner to match approved indication). Results: Visceral mets were identified in 293 pts (60.5%) in the RIB arm and 147 (60.7%) in the PBO arm in ML-3 and 150 (44.8%) and 142 pts (42.1%), respectively, in ML-7. In ML-3, the median age of pts with visceral mets was 63 and 65 years in the RIB and PBO arms, and in ML-7 it was 42.5 and 45.0 years, respectively. In ML-3, 214 pts with visceral mets received 1L therapy (RIB, n = 137; PBO, n = 77), while 219 pts received 2L therapy or had early relapse (RIB, n = 151; PBO, n = 68). Lung and liver were the most common sites of visceral mets for pts in ML-3 (49.8% and 44.8%, respectively) and ML-7 (51.4% and 58.2%, respectively). OS HRs in pts with visceral mets were consistent with the benefit in the overall pt populations and suggested a particularly substantial OS benefit in pts with liver mets (HR for liver mets group in ML-3, 0.629 [95% CI, 0.421-0.942]; HR in ML-7, 0.531 [95% CI, 0.321-0.877]; Table). No new safety signals were observed. Conclusions: Approximately half of the pts in ML-3 and ML-7 had visceral mets. The OS data in these pts are consistent with the benefit observed with RIB in the overall populations of each trial. In pts with liver mets, a group with an especially poor prognosis, RIB + ET demonstrated a substantial OS benefit compared with PBO + ET. Clinical trial information: NCT02422615; NCT02278120 . [Table: see text]
Electrospun nanofiber mesh with fibroblast growth factor and stem cells for pelvic floor repair (2019)

Abstract Surgical outcome following pelvic organ prolapse (POP) repair needs improvement. We suggest a new approach based on a tissue‐engineering strategy. In vivo, the regenerative potential of an electrospun biodegradable polycaprolactone (PCL) mesh was studied. Six different biodegradable PCL meshes were evaluated in a full‐thickness abdominal wall defect model in 84 rats. The rats were assigned into three groups: (1) hollow fiber PCL meshes delivering two dosages of basic fibroblast growth factor (bFGF), (2) solid fiber PCL meshes with and without bFGF, and (3) solid fiber PCL meshes delivering connective tissue growth factor (CTGF) and rat mesenchymal stem cells (rMSC). After 8 and 24 weeks, we performed a histological evaluation, quantitative analysis of protein content, and the gene expression of collagen‐I and collagen‐III, and an assessment of the biomechanical properties of the explanted meshes. Multiple complications were observed except from the solid PCL‐CTGF mesh delivering rMSC. Hollow PCL meshes were completely degraded after 24 weeks resulting in herniation of the mesh area, whereas the solid fiber meshes were intact and provided biomechanical reinforcement to the weakened abdominal wall. The solid PCL‐CTGF mesh delivering rMSC demonstrated improved biomechanical properties after 8 and 24 weeks compared to muscle fascia. These meshes enhanced biomechanical and biochemical properties, demonstrating a great potential of combining tissue engineering with stem cells as a new therapeutic strategy for POP repair. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:48–55, 2020.
StructureMapper: a high-throughput algorithm for analyzing protein sequence locations in structural data (2018)

Supplementary data are available at Bioinformatics online.
Mobile IPv6 Bootstrapping in Split Scenario (2007)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements.Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol.Distribution of this memo is unlimited.
Derivatization Design of Synthetically Accessible Space for Optimization: In Silico Synthesis vs Deep Generative Design (2021)

Molecular design is of utmost importance in lead optimization programs ultimately determining the fate of the project and the speed to reach preclinical stage. Newly designed lead analogues or new chemotypes must successfully address the challenges in the multidimensional optimization process throughout several optimization cycles. The speed, quality, and creativity of the designs can have a major impact on the cycle time, the number of required cycles, and the number of compounds needed to be synthesized and evaluated that in combination affect the overall timeline and cost of the lead optimization phase. Recently, a new concept, generative design with deep learning, has become popular for de novo design of project relevant analogue sets. We have developed a de novo design technology called "derivatization design" that applies artificial-intelligence-assisted forward <i>in silico</i> synthesis for the generation of near neighbor lead analogues as well as scaffold variations. The several attractive features of the methodology include synthetic feasibility, reagent availability and cost data associated with each new molecule; thus, detailed synthetic assessment is automatically generated during the design. As a result, these practically important data types can become an early part of the ranking and selection process for cycle time reduction. The power of derivatization design is demonstrated in a simple design study of DDR1 inhibitors and comparison of the produced molecules to a recently published data set obtained with deep generative design.
Comparison of the Effects of Coconut Oil and Soyabean Oil on TSH Level and Weight Gain in Rabbits (2009)

The present study was conducted on 12 albino rabbits of either sex and weighing between 1-1.5kg to see the influence of coconut oil and soyabean oil on serum TSH levels and weight gain for a period of 12 weeks.  The rabbits were divided into 2 groups of six each.  Rabbits in group 1 were fed on coconut oil and in group 2 were fed on soyabean oil in addition to their standard diet.  At the end of 12 weeks we found that rabbits fed on soyabean oil had significant increase in TSH levels (p= 0.003) and gained more weight (p=0.000) when compared to rabbits fed on coconut oil.
The Clinical Outcomes of New Hyaluronan Nasal Dressing: A Prospective, Randomized, Controlled Study (2013)

In this clinical study, data analyses suggest that this new absorbable hyaluronan hydrogel, as nasal dressing/packing after ESS is safe and promotes the postoperative reepithelization process and reduces the presence of synechia, edema, crust, and mild mucopurulent drainage.
ESTUDO DO EFEITO DE MATERIAL PARTICULADO NA FORMAÇÃO DA TORTA DE FILTRAÇÃO E NA INVASÃO DE FILTRADO (2015)

Partículas sólidas são usadas como adensante e material obturante na formulação de fluidos de perfuração. As características físico-químicas destes materiais têm forte influência na formação da torta e consequentemente na taxa de filtração e invasão de filtrado nas formações rochosas. A invasão indesejável pode causar danos irreversíveis à formação. Desta forma, o controle das propriedades da torta é fundamental no processo de perfuração de poços de petróleo. Neste trabalho, objetivou-se estudar o efeito da forma e da distribuição granulométrica de carbonato de cálcio e da esfera de vidro na taxa de filtração estática. Os experimentos foram realizados em uma célula high temperature/high presssure (HTHP) para a filtração estática e dinâmica em condições compatíveis com aquelas encontradas durante a perfuração de poços de petróleo. Concluiu-se que quando é utilizado um fluido não newtoniano ocorre a influência no volume de filtrado devido à interação da granulometria do carbonato de cálcio e goma
Transceive surface coil array for magnetic resonance imaging of the human brain at 4 T (2005)

As the static magnetic field strength used in human magnetic resonance imaging increases, the wavelength of the corresponding radiofrequency field becomes comparable to the dimensions of the coil and volume of interest. The dielectric resonance effects that arise in this full wavelength regime may be partially compensated for through the use of surface coils. A novel high-field (4 T) transceive surface coil array is presented that allows arbitrary surface coil placement and size while maintaining the ability to independently transmit and/or receive through conventional 50-ohm power amplifiers and preamplifiers, respectively. A ninefold signal-to-noise ratio (SNR) increase is shown in close proximity to the transceive array and there is an overall 38% increase throughout the entire brain volume in comparison to the standard hybrid birdcage coil. Furthermore, the ability to independently transmit and receive through each surface coil within this array enables transmit and/or receive-only fast parallel imaging techniques to be employed while maintaining the increased SNR sensitivity inherent to surface coil designs.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas. (2012)

Abstract An efficient one‐pot protocol for the synthesis of unsymmetrical ureas such as (IV) or (VII) via palladium‐catalyzed cross‐coupling of aryl chlorides and triflates with sodium cyanate and amines is developed.
Ferumoxytol Use as an Intravenous Contrast Agent for Magnetic Resonance Angiography (2011)

Data from small pilot studies suggest that ferumoxytol may improve image quality in MRA; however, further investigation is necessary to establish its efficacy and safety. Large randomized, active-comparator trials are needed to establish optimal dosing, imaging procedures, and safety monitoring.
ChemInform Abstract: DIRECT PREPARATION OF MANGANESE(I)‐ISOCYANIDE COMPLEXES (1973)

Abstract Hexaaquomangan(II)‐nitrat (I) liefert mit den Isocyaniden (IIa)‐(IIc) die Mangan‐Komplexe (IIIa)‐(IIIc) und (IVb).
MDL-motivated compression of GLM ensembles increases interpretability and retains predictive power (2016)

Over the years, ensemble methods have become a staple of machine learning. Similarly, generalized linear models (GLMs) have become very popular for a wide variety of statistical inference tasks. The former have been shown to enhance out- of-sample predictive power and the latter possess easy interpretability. Recently, ensembles of GLMs have been proposed as a possibility. On the downside, this approach loses the interpretability that GLMs possess. We show that minimum description length (MDL)-motivated compression of the inferred ensembles can be used to recover interpretability without much, if any, downside to performance and illustrate on a number of standard classification data sets.
Immunological signaling networks: Integrating the body's immune response1,2 (2007)

The role of the immune system is to protect against infection and to eliminate disease from the host. Nonimmune cells can not only act as physical barriers, but also respond to microbial stimulation to release antimicrobial molecules, whereas immune cells are primarily responsible for eliminating pathogens or cancerous cells. In addition, immune cells regulate the immune response affecting the types of cells that are activated or suppressed. The following discussion is an overview of the immune system and its interconnection with the host. How nonimmune cells and innate and adaptive immune cells work separately and together to respond to a pathogenic challenge is discussed. In addition, how the immune system can be affected by factors such as nutrition and stress, and how the immune system can affect factors such as fertility demonstrates the integration of the immune system in processes other than elimination of pathogens.
一个“外行的”领导观 (2001)

关于领导，人们已经写得太多了，以至于很难再写出或谈出新意，或者很难完全避免陈词滥调。我有这样一种感觉，我们大多数人将会说：“当我看到了领导我就知道了领导。”领导者常常是想象中的人、有效的交流者、有效的决策制定者和知识分子；他们尊重并重视个人和他们的尊严；他们许诺为组织服务并服从不可强迫的命令；他们要百分之百的诚实和正直：他们是平易近人的；以及他们常常认为自己是教师。
Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor (2013)

We report the synthesis of a GDP analogue, SML-8-73-1, and a prodrug derivative, SML-10-70-1, which are selective, direct-acting covalent inhibitors of the K-Ras G12C mutant relative to wild-type Ras. Biochemical and biophysical measurements suggest that modification of K-Ras with SML-8-73-1 renders the protein in an inactive state. These first-in-class covalent K-Ras inhibitors demonstrate that irreversible targeting of the K-Ras guanine-nucleotide binding site is potentially a viable therapeutic strategy for inhibition of Ras signaling.
Nuclear Data for Reactor Physics: Cross sections and level densities in the actinide region (2010)

Nuclear data in the actinide region are particularly important because they are basis behind all simulations of nuclear reactor core behaviour over both long time scales (fuel depletion and waste production) and short time scales (accident scenarios). Nuclear reaction cross sections must be known as precisely as possible so that core reaction rates can be accurately calculated. Although cross section measurements in this region have been widely performed, for certain nuclei, particularly those with short half lives, direct measurements are either very difficult or impossible and thus reactor simulations must rely on theoretical calculations or extrapolations from neighbouring nuclei. The greatest uncertainty in theoretical cross section calculations comes from the lack of knowledge of level densities, for which predicted values can often be incorrect by a factor of two or more. Therefore there is a strong case for a systematic experimental study of level densities in the actinide region for the purpose of a) providing a stringent test of theoretical cross section calculations for nuclei where experimental cross section data are available and b) for providing better estimations of cross sections for nuclei in which no cross section data are available.
Adsorption-Freezing Transition for Random Heteropolymers near Disordered 2D Manifolds due to “Pattern Matching” (1996)

We study the simplest model for random heteropolymers near chemically disordered surfaces, and predict a new phenomenon that may have implications for pattern recognition applications. As the strength of surface fluctuations increases a smooth adsorption transition occurs first, with a multitude of chain conformations being sampled. More interestingly, beyond a larger threshold value of the strength of surface fluctuations, a sharp second adsorption transition is observed that is accompanied by the polymer freezing into a few dominant conformations that match the pattern of the surface fluctuations.