gebhart/patrepeval huggingface dataset:
Efficient Collision Culling among Deformable Objects using Graphics Processors (2006)

February 01 2006 Efficient Collision Culling among Deformable Objects using Graphics Processors Naga K. Govindaraju, Naga K. Govindaraju Search for other works by this author on: This Site Google Scholar Ming C. Lin, Ming C. Lin Search for other works by this author on: This Site Google Scholar Dinesh Manocha Dinesh Manocha Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-3175 Search for other works by this author on: This Site Google Scholar Author and Article Information Naga K. Govindaraju Ming C. Lin Dinesh Manocha Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-3175 Correspondence to: naga@cs.unc.edu © 2006 by the Massachusetts Institute of Technology2006 Presence: Teleoperators and Virtual Environments (2006) 15 (1): 62–76. https://doi.org/10.1162/pres.2006.15.1.62 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Naga K. Govindaraju, Ming C. Lin, Dinesh Manocha; Efficient Collision Culling among Deformable Objects using Graphics Processors. Presence: Teleoperators and Virtual Environments 2006; 15 (1): 62–76. doi: https://doi.org/10.1162/pres.2006.15.1.62 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsPRESENCE: Virtual and Augmented Reality Search Advanced Search Abstract We present a fast collision culling algorithm for performing inter- and intra-object collision detection among complex models using graphics hardware. Our algorithm utilizes visibility queries on the GPUs to eliminate a subset of geometric primitives that are not in close proximity and computes a potentially colliding set (PCS) of primitives. We perform no precomputation and the algorithm proceeds in multiple stages: object-level PCS computation, subobject level PCS computation, followed by exact collision detection. We extend our PCS computation algorithm to perform intra-object or self-collisions between complex models. Furthermore, we describe a novel visibility-based classification scheme to reduce the size of potentially-colliding sets of objects and primitives, and the number of visibility queries for further improving the performance and culling efficiency. We have implemented our algorithm on a PC with an NVIDIA GeForce FX 6800 Ultra graphics card and applied it to three complex simulations, each consisting of objects with tens of thousands of triangles. In practice, we are able to compute all the self-collisions for cloth simulation up to image-space precision at interactive rates. This content is only available as a PDF. © 2006 by the Massachusetts Institute of Technology2006 You do not currently have access to this content.
Toward a PKB Inhibitor:  Modification of a Selective PKA Inhibitor by Rational Design (2002)

Protein kinase B/Akt (PKB) is an anti-apoptotic protein kinase that has strongly elevated activity in human malignancies. We therefore initiated a program to develop PKB inhibitors, “Aktstatins”. We screened about 500 compounds for PKB inhibitors, using a radioactive assay and an ELISA assay that we established for this purpose. These compounds were produced as combinatorial libraries, designed using the structure of the selective PKA inhibitor H-89 as a starting point. We have identified a successful lead compound, which inhibits PKB activity in vitro and in cells overexpressing active PKB. The new compound shows reversed selectivity to H-89: In contrast to H-89, which inhibits PKA 70 times better than PKB, the new compound, NL-71-101, inhibits PKB 2.4-fold better than PKA. The new compound, but not H-89, induces apoptosis in tumor cells in which PKB is amplified. We have identified structural features in NL-71-101 that are significant for the specificity and that can be used for future development and optimization of PKB inhibitors.
Biomaterials for Dental Surgical Implants (1993)

The evolution and current concepts of restorative dental implants are briefly reviewed. With more than 90% of the dental implant devices remaining stable after 15 years, the interest of all involved in the development and applications of musculoskeletal materials manufactured devices has been growing steadily. The article concludes with a discussion of the current materials, their applications, and in vivo reactivities.
Using subthreshold events to characterize the functional architecture of electrically coupled networks (2018)

Abstract The electrical connectivity in the inferior olive (IO) nucleus plays an important role in generating well-timed spiking activity. Here we combined electrophysiological and computational approaches to assess the functional organization of mice IO nucleus. Spontaneous fast and slow subthreshold events were commonly encountered during in vitro recordings. We show that the fast events represent a regenerative response in unique excitable spine-like structures in the axon hillock, whereas the slow events reflect the electrical connectivity between neurons (‘spikelets’). Recordings from cell pairs revealed the synchronized occurrence of distinct groups of spikelets; their rate and distribution enabled an accurate estimation of the number of connected cells and is suggestive of a clustered organization. This study thus provides a new perspective on the functional and structural organization of the olivary nucleus, insights into two different subthreshold non-synaptic events, and a novel experimental and theoretical approach to the study of electrically-coupled networks.
Somatic embryogenesis and Agrobacterium-mediated genetic transformation of geranium with chitinase-glucanase encoding genes. (2009)

Geranium (Pelargonium x hortorum) is a popular floricultural crop worldwide. This crop is attacked by various pathogenic fungi causing wilt and tip rots. Regeneration of ornamental geranium (Pelargonium x hortorum var Scarlet) was achieved through somatic embryogenesis using hypocotyl segments. The highest number of somatic embryos (12.60) per explant were obtained on MS medium containing 1.5mM thidizuron (TDZ) and somatic embryogenesis initiation was achieved in 14 days. Stable transgenic plants were obtained by co-cultivation of hypocotyls with Agrobacterium tumefaciens strains LBA 4404 harbouring the recombinant binary vector pBINAR vector containing chitinase-glucanase encoding gene. Transformants were selected using kanamycin (100 mg/l). Transgenic integration was confirmed by PCR and by southern blot analysis. Glucanase activity in the leaf of primary transformants was nearly double compared to non-transformed leaves. In-vitro testing of Fusarium growth by crude protein of transformed leaves showed 1.5 cm diameter of inhibition zone as against non-transformed leaves where it was 0.5 cm. The combined expression of these plant-defence proteins should be able to enhance the plant's resistance to fungal attack.
Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony- stimulating factor (1988)

Pure interleukin 1 (IL 1) was found to stimulate established human bone marrow stromal layers in long-term culture to produce colony-stimulating activity (CSA). Maximal concentrations in the culture medium were reached 24 hours after a single IL 1 pulse. The effect could be neutralized by a specific rabbit anti-IL 1 antiserum. Stromal layers, once stimulated by IL 1, continued to release CSA into the culture medium in the absence of exogenous IL 1. A second IL 1 pulse induced CSA release in an identical manner, as did the primary stimulation, indicating that the CSA released was actively produced. Using specific immunologic assays, both granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) could be identified in the culture supernatants, and production of both factors was inducible by IL 1. Shortly after initiation of the long-term marrow cultures "spontaneous" G-CSF and M-CSF release occurred. The release of G-CSF diminished following addition of the anti-IL 1 antiserum, indicating that endogenous production of IL 1 by stromal cells had contributed to this effect. These results further support the role of IL 1 as an important modulator of CSF production by cells of the hematopoietic microenvironment.
Triacontanol and Its Second Messenger 9-β-l(+)-Adenosine as Plant Growth Substances (1991)

Triacontanol (TRIA), a common constituent of plant waxes, was first shown in 1977 to be an active growth substance which at nanomolar concentrations increased the growth and yield of crops. TRIA is used to increase crop yields on millions of hectares, particularly in Asia. Many investigators have shown that it affects several basic metabolic processes including photosynthesis, nutrient uptake, and enzyme activity. However, the initial site of action has not been elucidated. TRIA rapidly elicits a second messenger (TRIM) in rice (Oryza sativa L.), which at nanomolar concentrations causes plants to respond in a manner similar to TRIA. TRIM has been identified as 9-beta-l(+)-adenosine (9H-purin-6-amine, 9-beta-l-ribofuranosyl). During the process of isolating and identifying 9-beta-l(+)-adenosine, it was shown that this enantiomer, which previously has not been reported as occurring in nature, made up about 1% of the total adenosine pool in roots from untreated rice seedlings.
Optimization of extension doping technology for roll-off suppression of industrial 0.1-um pMOSFETs (2000)

For the very first time, low biased PLAD technique was integrated in an industrial 0.1-μm pMOSFET process fabrication. The electrical results emphasize that an optimized PLAD process could overcome the limitations of the conventional ion implantation technique for the fabrication of the ultra-shallow P/N junctions required by the future CMOS technology.
Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes (2019)

The Ser/Thr protein kinase Akt regulates essential biological processes such as cell survival, growth, and metabolism. Upon growth factor stimulation, Akt is phosphorylated at Ser<sup>474</sup>; however, how this phosphorylation contributes to Akt activation remains controversial. Previous studies, which induced loss of Ser<sup>474</sup> phosphorylation by ablating its upstream kinase mTORC2, have implicated Ser<sup>474</sup> phosphorylation as a driver of Akt substrate specificity. Here we directly studied the role of Akt2 Ser<sup>474</sup> phosphorylation in 3T3-L1 adipocytes by preventing Ser<sup>474</sup> phosphorylation without perturbing mTORC2 activity. This was achieved by utilizing a chemical genetics approach, where ectopically expressed S474A Akt2 was engineered with a W80A mutation to confer resistance to the Akt inhibitor MK2206, and thus allow its activation independent of endogenous Akt. We found that insulin-stimulated phosphorylation of four <i>bona fide</i> Akt substrates (TSC2, PRAS40, FOXO1/3a, and AS160) was reduced by ∼50% in the absence of Ser<sup>474</sup> phosphorylation. Accordingly, insulin-stimulated mTORC1 activation, protein synthesis, FOXO nuclear exclusion, GLUT4 translocation, and glucose uptake were attenuated upon loss of Ser<sup>474</sup> phosphorylation. We propose a model where Ser<sup>474</sup> phosphorylation is required for maximal Akt2 kinase activity in adipocytes.
Erratum: Theoretical study on quantum effects in triangular antiferromagnets with axial anisotropy using the numerically constructed Bogoliubov transformation for magnons (1996)

The analysis of microwave dielectric data for TMTSF-based compounds has generated a lot of discussion recently. 1 Testing for the validity of the microwave resistivity approximation is of special interest.
47.3: Analysis of Subtriad Addressing Algorithms by Visual System Models (2001)

Abstract Recently, there is a renewed interest in improving the perceived horizontal resolution of triad‐pixel displays, such as LCDs. These techniques consider the spatial displacements of the individual red, green, and blue subpixels of the single displayed color pixel. Valid luminance information is essentially carried on a chromatic aliasing signal. Using spatiochromatic visual models, we present an analysis of the visibility of the false chromatic signal, as well as the additional luminance bandwidth.
Design and performance of a passive EMI filter for use with a voltage-source PWM inverter having sinusoidal output voltage and zero common-mode voltage (2003)

This paper deals with integrating a small-sized passive EMI filter with a voltage-source PWM inverter. The purpose of the filter is to eliminate both high-frequency common-mode and normal-mode voltages from the three-phase output voltages of the inverter. A laboratory system consisting of a 5-kVA inverter, a 3.7-kW induction motor, and a specially-designed passive EMI filter was constructed to verify the viability and effectiveness of the filter. As a result, both line-to-line and line-to-neutral output voltages look purely sinusoidal as if the inverter were an ideal three-phase variable-voltage, variable-frequency power supply, when the inverter is viewed from the motor terminals. This results in a complete solution to serious EMI issues related to high-frequency common-mode and normal-mode voltages produced by the PWM inverter.
[Estimation of L-selectin expression on neutrophils and level of soluble L-selectin form in serum of patient with chronic myelogenic leukemia]. (2006)

The aim of this study was the estimation of L-selectin expression on PMN and concentration of sL-selectin in patients serum with chronic myelogenic leukemia. The results indicate the increased expression of L-selectin on isolated neutrophils from peripheral blood of patients with chronic myelogenic leukemia. A concentration of sL-selectin was also increased in patients serum with chronic myelogenic leukemia. High concentration of L-selectin on PMN makes binding neoplastic cells easier. Increased level of sL-selectin might activate of the adhesion process in patients with chronic myelogenic leukemia. High expression of L-selectin on PMN may be a response to higher levels of TNF-alpha in serum blood patients with chronic myelogenic leukemia.
SMALL-SCALE ELECTRON DENSITY FLUCTUATIONS IN THE HALL THRUSTER, INVESTIGATED BY COLLECTIVE LIGHT SCATTERING (2009)

Les oscillations dans le plasma d'un propulseur à effet Hall sont susceptibles de provoquer le transport anormal à travers des lignes du champ magnétique. La théorie cinétique linéaire montre qu'en particulier certaines oscillations, de fréquence de l'ordre du mégahertz et de longueur d'onde millimétrique, peuvent jouer un rôle important dans le transport anormal. Les échelles caractéristiques de ces fluctuations ne sont pas détectables par des outils standards comme les sondes. Ce travail décrit pour la première fois l'utilisation d'un diagnostic de diffusion collective (PRAXIS) conçu pour l'étude du plasma du propulseur, qui a mené à l'identification des modes instables dans le plasma. Deux modes hautes fréquences ont été identifiés, se propageant dans les directions azimutale et axiale, avec des longueurs d'onde millimétriques et des fréquences de l'ordre du mégahertz. Les directions de propagation et les ouvertures angulaires de ces modes ont été déterminées. Le mode azimutal, identifié dans la théorie comme agent principal du transport, possède des composantes anti-parallèles au champ magnétique et parallèles au champ électrique et se propage dans une ouverture angulaire très restreinte. Le mode axial montre des caractéristiques liées à la vitesse et la divergence du faisceau d'ions. Le niveau de fluctuation de la densité est associé à une grande amplitude du champ électrique fluctuant. Les résultats des expériences sont en accord avec les prévisions théoriques et apportent de nouvelles informations, permettant ainsi d'améliorer et de développer des modèles pour les deux modes
Gout among Patients with Dialysis: Prevalence, Associated Factors, Treatment Patterns, and Outcomes—Population-Based Retrospective Cohort Study (2022)

Key Points Population-based retrospective cohort study to evaluate clinical correlates of gout and its impact on patients undergoing chronic dialysis. 13.5% of US dialysis-dependent patients had gout and were older and male, with a higher prevalence of hypertension and cardiovascular disease. Gout diagnosis was associated with a higher incidence of cardiovascular conditions, levels of anemia, hospitalization, and mortality. Background An association between gout and nondialysis chronic renal disease has long been recognized, yet limited research exists regarding prevalence, treatment, anemia management, and outcomes in patients with ESKD undergoing dialysis. Methods Using data from United States Renal Data System, we conducted a population-based retrospective cohort study in adult patients covered by Medicare and on dialysis in 2017. Multivariate logistic regression models were used to estimate potential factors and odds of gout diagnosis. Antigout medications and impact on anemia management were assessed and compared between gout and nongout dialysis patients using descriptive and regression analyses. Associations for all-cause mortality and cardiovascular-related hospitalizations during 1 year of study follow-up were compared between gout and nongout patients using multivariate Cox regression models. Results Of 231,841 ESKD Medicare patients in 2017 undergoing continuous dialysis, 31,300 (13.5%) had one or more gout diagnostic code(s). Increased odds of having a gout diagnosis were independently associated with older age, male sex, Asian race, obesity, hypertension, and cardiovascular disease. Gout diagnosis was associated with higher prevalence for anemia as indicated by increased erythropoietin-stimulating agent requirements (odds ratio=1.18 for high versus low erythropoietin-stimulating agent dose, 95% confidence interval [95% CI], 1.14 to 1.22) and likelihood of blood transfusions (odds ratio=1.34, 95% CI, 1.30 to 1.38). During the 1-year study follow-up, mortality among gout versus nongout patients was higher by 3% (95% CI, 0 to 6) and a composite association of mortality and cardiovascular disease hospitalization was higher by 6% (95% CI, 3 to 9) after adjusting for comorbid conditions. Conclusions A gout diagnosis was found in 13.5% of US dialysis-dependent patients and was associated with a higher burden of comorbid cardiovascular conditions as well as an elevated incidence of hospitalization and mortality. These observations improve our current understanding of gout among the dialysis population and highlight the importance of new and better treatments to improve outcomes.
Scale up of a chromatographic capture step for a clarified bacterial homogenate – Influence of mass transport limitation and competitive adsorption of impurities (2020)

A model-based approach for scaling up chromatographic capture step was developed. The purification of human basic fibroblast growth factor protein 2 (FGF2) from an E. coli homogenate on a cation exchange resin was selected as a case study. Non-ideal effects accompanying the capture operation were examined, including: reduction in the protein diffusivity in the presence of the homogenate, competitive adsorption between FGF2 and undefined impurities, and flow behavior in external column volumes. The viscosity of the homogenate was measured as a function of dilution degree and shear stress, and its contribution to the diffusivity reduction was quantified. A dynamic model was formulated which accounted for underlying kinetic and thermodynamic dependencies. The model parameters were determined for a lab scale system using a small 2-mL column. The model was successfully used to scale up the capture operation from the lab scale column to a preparative bench scale column of about 1 L volume.
Design considerations in PCM transmission of low-resolution monochrome still pictures (1967)

We present some results concerning the effects of changes in system parameters on the picture quality in PCM transmission systems. We restrict our attention to low-resolution monochrome still pictures, and discuss in particular the effects of the number of samples per frame, the number of brightness levels, the scanning pattern, and the channel noise, with a view to the optimal choice of these parameters.
Optical quality of foldable monofocal intraocular lenses before and after injection (2009)

Results indicate that after an IOL is placed in the eye, its optical performance will be good, providing good visual quality. The eye cell model attached to the double-pass system was useful and effective for fully characterizing the optical quality of IOLs and evaluating variations resulting from the injection process.
Electrical characteristics of layered palladium alkanethiolates by conducting atomic force microscopy (2008)

Current-voltage measurements on individual Pd(II) alkanethiolate nanostructures of varying bilayer thicknesses (hexyl to hexadecyl) employing conducting atomic force microscopy have shown the presence of a low current region near zero bias, the width of which increases with the bilayer thickness. The resistance in this region varies exponentially with the bilayer thickness with a low decay parameter value of 0.2±0.04Å−1 indicating a long-range nonresonant tunneling through the alkyl chains. The changeover from low current to high current with increasing bias is accompanied by a negative differential resistance feature, which arises due to Pd–S charge transfer.
Abstract 522: VWF Inhibition by an RNA Aptamer Improves Functional Outcome Compared to rTPA in Ferric Chloride-induced Carotid Artery Thrombosis in Mice (2018)

Objective: To compare the functional effects of von Willebrand Factor (VWF) inhibition by RNA aptamer (T79) vs rTPA utilizing in vivo arterial thrombosis in mice. Approach and Results: We previously demonstrated that inhibition of VWF by a targeted RNA aptamer (T79) both prevents thrombosis and thrombolyses stabilized clots in a murine model of ferric chloride (FeCl 3 )-induced vascular injury suggesting a pivotal role for VWF in the pro-thrombotic and anti-thrombotic milieu. We hypothesized that T79 treatment, which demonstrated no hemorrhagic complications and greater re-perfusion compared to rTPA, would result in improved behavioral outcome with 7 day survival after vascular injury. Baseline locomotor testing in an open field was performed on both male and female, 8-16 week old, wild-type C57BL/6J mice. Occlusive arterial thrombus formation was induced by a 3 minute exposure to 10% FeCl 3 on the right common carotid monitored by Doppler flow and time to occlusion (blood flow of 0 ml/min) was measured. Twenty minutes after thrombus stabilization either T79 (0.1 mg/kg or 0.5 mg/kg bolus), rTPA (10 mg/kg 45 min infusion) or saline vehicle (45 min infusion) was introduced via a saphenous catheter. Animals were recovered and locomotor testing was repeated 48 hours and 7 days after injury with baseline set as 100%. All groups including vehicle control resulted in a statistically significant decrease in distance traveled (meters) and speed (meters/sec) at 48 hours after injury. At 7 days, 0.1 mg/kg T79 increased 29.89% from 48 hours, 0.5 mg/kg T79 increased 22.50% from 48 hours but rTPA treatment showed no significant improvement (2.79% increase) (n=4, p&lt;0.001). In addition, 0.1 mg/kg and 0.5 mg/kg T79 resulted in a 28.46% and 22.44% increase in speed, respectively, at 7 days compared to 48 hours whereas rTPA did not (2.94% increase) (n=4, p&lt;0.001). Interestingly, males scored lower on most behavioral parameters at 48 hours, but recovered to the same level as females by 7 days. No significant differences in time to occlusion or baseline locomotor testing were observed in any group. Conclusion: Inhibition of VWF by T79 aptamer markedly improves behavioral outcomes compared to rTPA after survival carotid artery occlusion following ferric chloride-induced injury in mice.