gebhart/patrepeval huggingface dataset:
The Narrow Focus of Minimalism in Films -Hidden Genres, Strategies, and Pleasures (2011)

Most feature films use the traditional three-act story structure that employs an active protagonist facing clear obstacles, and through his/her will through a pattern of escalating conflict, culminate into a final and irreversible climax that creates a closed ending. However, several international and prominent filmmakers use a different approach to storytelling, which one can label as Minimalism. These films follow a passive protagonist who goes through his/her daily routine in a specific time and space frame, embodying a shallow dramatic arc in which not much happens and often results in an open end with no resolution. This approach to story is often visualized through a spare visual aesthetic: long takes, eye-level camera angles, long shots, minimum camera movement, and wide-angle lenses which does not visually emphasize certain dramatic moments but treats all moments in the story as the same. These films strive to capture what is extraordinary in the ordinary moment. Rather than trying to re-create the mundane world or facade of reality, minimalism, by stripping so much away, strives to capture the minute, but ever shifting, changes of human behavior, and reveal what we normally cannot see: characters being rather than doing. The use of episodic storytelling strings a series of moments that stand by themselves rather than building into a larger arc of conflict. Vignettes focus only on a moment itself between characters to create an impression or an idea in the audience with no set-up, development, or resolution as in a plot.
Contact between 3 phakic intraocular lens models and the crystalline lens: An anterior chamber optical coherence tomography study (2004)

Three phakic intraocular lens (IOL) models were implanted in 3 different patients. With the usual slitlamp examination, it was not possible to determine whether there was contact between the IOLs and the natural crystalline lens. Using the anterior chamber optical coherence tomography (AC OCT) scanner, direct contact between the natural crystalline lens and the 3 phakic IOLs was revealed. A dynamic study of the contact was performed during accommodation. These observations show that examination of the anterior segment with the AC OCT scanner provides new data about the status of the anterior segment after implantation of phakic IOLs.
A paradoxical relationship between hemoglobin A1C and in-hospital mortality in intracerebral hemorrhage patients (2019)

Among patients with no reported history of diabetes, both very low and very high HbA1c were directly associated with higher in-hospital mortality. Only very low HbA1c was associated with higher mortality in known diabetic patients. Further studies are needed to better define the relationship between HbA1c and outcomes, for it may have important implications for care of ICH patients.
A Methodological Framework for SysML: a Problem Frames-based Approach (2007)

Recently, SysML has been adopted by the Object Management Group as a modelling language for Systems Engineering. SysML is a UML profile that represents a subset of UML 2 with extensions. A wide adoption of the language could be hindered by the lack of a methodology that drives the modelling activities. Problem Frames (PFs) are a rigorous approach to requirements modelling that has the potential to improve the software development process. Unfortunately, PFs are not supported by an intuitive notation and easy to use tools. As a consequence, their adoption in industry is limited. This paper explores the possibility of exploiting the PFs ideas in the context of SysML models. The goal is to provide model-based development processes using SysML with a set of concepts and guidelines that are sound and have already been used and validated.
Device for the control of oxygen concentration in multiwell cell culture plates (2009)

Oxygen is a key modulator of many cellular pathways but current devices permitting in vitro oxygen modulation fail to meet the needs of many researchers. In this study, a microfabricated insert for multiwell formats has been developed to control the gas concentration of each well independent of the global incubator's condition. The platform consists of a polydimethylsiloxane (PDMS) insert that nests into a standard multiwell plate and serves as a passive network with a gas permeable membrane aimed to deliver gas to adherent cell cultures. Preliminary data demonstrate that the insert is effective in controlling the oxygen concentration at the cell surface inside a well with equilibration times in minutes rather than hours for conventional technologies. A wide variety of oxygen profiles can be attained based on the device design, such as the cyclic profile achieved in this study, and even gradients in local oxygen concentration to mimic those found in vivo for more biomimetic cellular models.
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 (2013)

Metastatic colorectal cancer (CRC) is incurable for most patients. Since mammalian target of rapamycin (mTOR) has been suggested as a crucial modulator of tumor biology, we aimed at evaluating the effectiveness of mTOR targeting for CRC therapy. To this purpose, we analyzed mTOR expression and the effect of mTOR inhibition in cancer stem-like cells isolated from three human metastatic CRCs (CoCSCs). CoCSCs exhibited a strong mTOR complex 2 (mTORC2) expression, and a rare expression of mTOR complex 1 (mTORC1). This latter correlated with differentiation, being expressed in CoCSC-derived xenografts. We indicate Serum/glucocorticoid-regulated kinase 1 (SGK1) as the possible main mTORC2 effector in CoCSCs, as highlighted by the negative effect on cancer properties following its knockdown. mTOR inhibitors affected CoCSCs differently, resulting in proliferation, autophagy as well as apoptosis induction. The apoptosis-inducing mTOR inhibitor Torin-1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly, Torin-1 did not affect the survival of normal colon stem cells in vivo, suggesting its selectivity towards cancer cells. Thus, we propose Torin-1 as a powerful drug candidate for metastatic CRC therapy.
Modal Analysis Employing In-plane Strain of Cantilever Plates Undergoing Translational Acceleration (2005)

A modeling method for the modal analysis of cantilever plates undergoing in-plane translational acceleration is presented in this paper. Cartesian deformation variables are employed to derive the equations of motion and the resulting equations are transformed into dimensionless forms. To obtain the modal equation from the equations of motion, the in-plane equilibrium stram measures are substituted into the stram energy expression based on Von Karman stram measures. The effects of two dimensionless parameters (related to acceleration and aspect ratio) on the modal characteristics of accelerated plates are investigated through numerical studies.
The Hypocholesterolemic Effects of β-Glucan (1991)

<h3>To the Editor.</h3> —There are several troubling aspects to the recent article by Davidson et al<sup>1</sup>on oat products. In their study, the authors purport to show a dose-response effect of 28, 56, and 84 g (1,2, and 3 oz, respectively) of oat products per day on serum cholesterol levels. Unfortunately, proper control was lacking in the authors' design, which renders their conclusion untenable. To show an independent action of oats, it is critical to use for a control the identical amount of a low-fiber cereal product, such as refined wheat. The authors actually compared 28, 56, and 84 g of oat products (28 g is equivalent to one serving of oatmeal or oat bran) with 28 g of wheat. The only well-controlled comparison in this study, 28 g of oats vs 28 g of wheat, showed no statistically significant effect of the oats. Incredibly, the conclusion of the
A mixed wave finite-element approach for solving Biot’s poroelasticity equations in acoustics (1999)

The use of finite-element models for solving Biot’s poroelasticity equations often leads to large frequency-dependent systems. Recently, the authors have investigated the use of a selective modal analysis to decrease the size of large finite-element models involving poroelastic structures. The method used a dual real modal basis associated with the skeleton in vacuo and the fluid phase occupying the volume of the porous material to approximate the {U,p} variables. However, this method converges poorly due to the importance of the damping brought in by the porous material. In this paper, an alternate reduction technique, based on a plane waves expansion method combined with a finite-element approach, is investigated in the case of a single porous layer. The theory behind the technique, together with numerical examples illustrating the performance of the approach, will be presented. [Work supported by Centre Jacques Cartier.]
Putative clinical and genetic antecedents of dementia associated with Parkinson's disease (1996)

Dementia is a constant manifestation of Parkinson's disease; it is the third most common cause of dementia after Alzheimer's disease and stroke. The clinical manifestations are similar to those seen in other degenerative disorders that cause dementia with some minimal differences; some specific disturbances such as depression and a decline in verbal fluency may identify individuals who are in the early stages of dementia. While patients advanced in age seem to be at higher risk of dementia with Parkinson's disease, the risk is uniform throughout the duration of disease. There are no known environmental risk factors specific for dementia, though many putative factors have been identified for Parkinson's disease. There is a strong evidence to suggest a genetic etiology, but more work is essential because of the unusual relationship between Alzheimer's disease, Lewy body dementia and the dementia of Parkinson's disease.
Three dimensional electrical impedance tomography of the human thorax (2002)

A problem associated with two dimensional (2D) EIT is that the injected current is not confined to the plane in which it is applied. Off-plane conductivity changes therefore have a significant effect on the reconstructed image. We have implemented a 3D reconstruction algorithm with 64 electrode data collection system and have produced 3D images of the human thorax.
Lack of Effect of Lithium Carbonate in Patients With Glycogenosis Ib (1987)

Lithium carbonate has been observed to induce neutrophilia in psychiatric patients and has been used in a number of childhood neutropenic disorders. We tried lithium carbonate in three children with glycogenosis Ib to see if the drug would alleviate the neutropenic complications of the disorder. Mean absolute neutrophil counts rose in one patient but not in the other two. Despite high-dosage schedules, serum lithium levels were highly erratic. Two patients developed potentially severe side effects, including polyuria, diarrhea, and altered mental status. One patient developed pneumonia despite a neutrophil count rise in response to therapy. Lithium carbonate is not useful in patients with glycogenosis Ib.
Wideband Radomes for Millimeter-Wave Automotive Radars (2021)

We demonstrate the efficacy of periodic corrugations, fabricated as part of the radar cover to serve the dual purpose of protecting the radar circuitry and maximizing transmission in millimeter-wave (mmW) automotive radars. A 2-D array of square-base pyramids engraved on the plastic radar cover was optimized to achieve minimum reflection for a wide range of incident angles, ±40°, and across the operating frequency band of 76–81 GHz. More importantly, we present an alternative radome texture, namely, the inverse-pyramid corrugations, which results in improved structural integrity compared to the pyramidal corrugations. This novel inverse-pyramid radome structure is also much easier to manufacture and achieves similar performance as the more conventional pyramid structure. Both designs are shown to significantly reduce radar cover reflections, which is perhaps the most significant bottleneck in modern mmW automotive radar sensor performance.
$\mu\mathrm{NF}$: A Disaggregated Packet Processing Architecture (2019)

Network Function Virtualization (NFV) promises to reduce the capital and operational expenditure for network operators by moving packet processing from purpose-built hardware to software running on commodity servers. However, the state-of-the-art in NFV is merely replacing monolithic hardware with monolithic Virtual Network Functions (VNFs), i.e., software that realizes different network functions. This is a good first step towards deploying NFV, however, common functionality is repeatedly implemented in monolithic VNFs. Repeated execution of such redundant functionality is particularly common when VNFs are chained to realize Service Function Chains (SFCs) and results in wasted infrastructure resources. This stresses the need for re-architecting the NFV ecosystem, through modular VNF design and flexible service composition. From this perspective, we propose MicroNF ( μNF in short), a disaggregated packet processing architecture facilitating the deployment of VNFs and SFCs using reusable and independently deployable components. Experimental results show that compared to monolithic VNF based SFCs, μNF-based ones achieve the same throughput by using less CPU cycles per packet on average.
Empagliflozin added to metformin and sulfonylurea therapy in patients with sub-optimally controlled type 2 diabetes mellitus (2015)

The combination of metformin and a sulfonylurea is commonly used in type 2 diabetes mellitus. Many patients on this combination therapy do not achieve or maintain glycemic targets and require the addition of a third antihyperglycemic agent. Among the options are the sodium glucose cotransporter 2 (SGLT2) inhibitors, a recently developed class of medications that effectively improve glycemic control and are associated with reduction in body weight and blood pressure. This article evaluates a 24-week, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin, added to metformin plus sulfonylurea regimens. Empagliflozin led to significant reductions in glycated hemoglobin and fasting plasma glucose, as well as body weight and systolic blood pressure. Adverse events typically recorded with SGLT2 inhibitors were observed; notably, genital infections occurred in more patients on empagliflozin than placebo. Overall, empagliflozin was well tolerated. These results indicate that SGLT2 inhibitors can be successfully added to metformin plus sulfonylurea regimens. SGLT2 inhibitors are not the only therapeutic option in this clinical situation; however, based on the secondary effects observed in this and other studies, they appear to be of particular value for patients who are obese or overweight.
Genetic Analysis of the Transition from Wild to Domesticated Cotton ( Gossypium hirsutum L.) (2019)

Abstract The evolution and domestication of cotton is of great interest from both economic and evolutionary standpoints. Although many genetic and genomic resources have been generated for cotton, the genetic underpinnings of the transition from wild to domesticated cotton remain poorly known. Here we generated an intraspecific QTL mapping population specifically targeting domesticated cotton phenotypes. We used 466 F2 individuals derived from an intraspecific cross between the wild Gossypium hirsutum var. yucatanense (TX2094) and the elite cultivar G. hirsutum cv. Acala Maxxa, in two environments, to identify 120 QTL associated with phenotypic changes under domestication. While the number of QTL recovered in each subpopulation was similar, only 22 QTL were considered coincident (i.e., shared) between the two locations, eight of which shared peak markers. Although approximately half of QTL were located in the A-subgenome, many key fiber QTL were detected in the D-subgenome, which was derived from a species with unspinnable fiber. We found that many QTL are environment-specific, with few shared between the two environments, indicating that QTL associated with G. hirsutum domestication are genomically clustered but environmentally labile. Possible candidate genes were recovered and are discussed in the context of the phenotype. We conclude that the evolutionary forces that shape intraspecific divergence and domestication in cotton are complex, and that phenotypic transformations likely involved multiple interacting and environmentally responsive factors.
A Unified Mode of Epigenetic Gene Silencing: RNA Meets Polycomb Group Proteins (2005)

Recently, an essential role for RNA in the epigenetic silencing of genes packaged within heterochromatin in animals has been recognized. The RNA appears to be involved in targeting chromatin remodeling activity to a specific locus and in later maintaining the repressed state of the gene. Epigenetic silencing of Hox cluster genes by the Polycomb group proteins also involves the formation of a stably inherited repressive chromatin structure. Recent studies of the C. elegans PcG gene sop-2 reveled an evolutionarily conserved property of PcG proteins in the binding of RNA, suggesting an important role for RNA in PcG-mediated Hox gene repression.
You cannot tell a book by looking at the cover: Cryptic complexity in bacterial evolution (2014)

Do genetically closely related organisms under identical, but strong selection pressure converge to a common resistant genotype or will they diverge to different genomic solutions? This question gets at the heart of how rough is the fitness landscape in the local vicinity of two closely related strains under stress. We chose a Growth Advantage in Stationary Phase (GASP) E scherichia coli strain to address this question because the GASP strain has very similar fitness to the wild-type (WT) strain in the absence of metabolic stress but in the presence of metabolic stress continues to divide and does not enter into stationary phase. We find that under strong antibiotic selection pressure by the fluoroquinolone antibiotic ciprofloxacin in a complex ecology that the GASP strain rapidly evolves in under 20 h missense mutation in gyrA only 2 amino acids removed from the WT strain indicating a convergent solution, yet does not evolve the other 3 mutations of the WT strain. Further the GASP strain evolves a prophage e14 excision which completely inhibits biofilm formation in the mutant strain, revealing the hidden complexity of E. coli evolution to antibiotics as a function of selection pressure. We conclude that there is a cryptic roughness to fitness landscapes in the absence of stress.
Risky Business: Managing Closely Held Assets in Trusts and Estates (1998)

Journal Article Risky Business: Managing Closely Held Assets in Trusts and Estates Get access Mary G. Boehler Mary G. Boehler The Northern Trust CoFifty South La Salle Street, Chicago, Illinois 60675, United States of America Search for other works by this author on: Oxford Academic Google Scholar Trusts & Trustees, Volume 4, Issue 9, September 1998, Pages 18–23, https://doi.org/10.1093/tandt/4.9.18 Published: 01 September 1998
Fourth-order interference technique for determining the coherence time of a light beam (1989)

A new experimental procedure for determining the (second-order) coherence time of a light beam is described that is based on a combination of conventional interferometry with an intensity-correlation technique. It permits measurements of coherence times that are several orders of magnitude shorter than the resolving times of the detectors, which ordinarily limit correlation measurements. The validity of the method is demonstrated by an experiment in which the transverse fluorescent light from a dye laser is measured.
Extended-range digital holographic imaging (2010)

We report the results of experiments demonstrating large-format coherent imaging at a range of 1.5 km. For this work, we use digital holographic detection to record coherent data and are thus able to measure the complex-valued optical field from a flood-illuminated scene over an extended aperture. Images are formed using digital Fourier processing. The return light is interfered with a coherent reference beam, and the intensity of the interference pattern is recorded using a conventional large-format detector array. Experimental results obtained using a coherent, pulsed laser source operating at 1.6 microns are presented. We also demonstrate the utility of this technique for advanced imaging functions such as 3D imaging.
A federated Edge Cloud-IoT architecture (2016)

The provisioning of powerful decentralized services in the Internet of Things (IoT), as well as the integration of innovative IoT platforms, requires ubiquity, reliability, high-performance, efficiency, and scalability. Towards the accomplishment of the above requirements, the contemporary technological trends leaded to the IoT and Cloud convergence. This combination created the approach of federated Cloud-IoT architectures. The Cloud-IoT architectural vision is paving the way to the vital step, beyond the IoT cognitive capabilities, that refers to the IoT world leveraging cloud principles. For the success of the deployment of such innovative and high-performance solutions, the introduction and the exploitation of 5G technological principles will empower the way forward. Towards this direction, this paper presents a federated architecture combined by distributed Edge Cloud-IoT platforms, that enables the semantic-based service combination and provisioning. The 5G technological features, such as low-latency, zero-losses, high-bitrates are studied and proposed for the empowerment of the federation of the Edge Cloud-IoT architectures. A smart health use case is presented for the evaluation of the proposed solution.
Improving the crystallinity and texture of oblique-angle-deposited AlN thin films using reactive synchronized HiPIMS (2023)

Many technologies, such as surface-acoustic-wave (SAW) resonators, sensors, and piezoelectric MEMS require highly-oriented and textured functional thin films. The best results are typically achieved for on-axis sputter geometries, but in some scenarios, this is not feasible, such as during co-deposition from multiple magnetrons or when coating substrates with high aspect ratios. Ionized physical vapor deposition (PVD) techniques such as HiPIMS can be used to accelerate the film-forming species onto the growing film using substrate-bias potentials, thus increasing ad-atom mobility and film texture. However, gas-ion incorporation can limit the feasibility of such synthesis approaches for defect-sensitive functional thin films. This work reports on the oblique-angle deposition of highly textured, c-axis oriented AlN (0002) films using reactive metal-ion synchronized HiPIMS. AlN thin films deposited using direct current magnetron sputtering (DCMS) and HiPIMS are discussed for comparison and the effect of ion irradiation through substrate biasing is investigated. We find that combining HiPIMS with a moderate substrate bias of only −30 V improves the crystalline quality and texture of the films significantly, while the process-gas incorporation and point defects formation can be further reduced by synchronizing the negative substrate bias potential to the Al-rich fraction of each HiPIMS pulse. In addition to a pronounced out-of-plane texture, the films show uniform polarization of the grains making this synthesis route suitable for piezoelectric applications. While the compressive stress in the films is still comparatively high, the results already demonstrate, that metal-ion synchronized HiPIMS can yield promising results for the synthesis of functional thin films under oblique-angle deposition conditions - even with low substrate-bias potentials.