gebhart/patrepeval huggingface dataset:
Nonlinear aeroelastic behavior of compliant airfoils (2010)

Since the beginning of aviation and up to the present time, airfoils have always been built as rigid structures. They are designed to fly under their divergence speed in order to avoid static aeroelastic instabilities and the resulting large deformations, which are not compatible with the typically low compliance of such airfoils. In recent years, research on airfoil morphing has generated interest in innovative ideas like the use of compliant systems, i.e. systems built to allow for large deformations without failure, in airfoil construction. Such systems can operate in the neighborhood of divergence and take advantage of large aeroelastic servo-effects. This, in turn, allows compact, advanced actuators to control the airfoil's deformation and loads, and hence complement or even replace conventional flaps. In order to analyze and design such compliant, active aeroelastic structures a nonlinear approach to static aeroelasticity is needed, which takes into account the effect of large deformations on aerodynamics and structure. Such an analytical approach is presented in this paper and applied to a compliant passive airfoil as the preliminary step in the realization of a piezoelectrically driven, active aeroelastic airfoil. Wind tunnel test results are also presented and compared with the analytic prediction. The good agreement and the observed behavior in the wind tunnel give confidence in the potential of this innovative idea.
Supplementary Figures 1-9 from MicroRNA-138 Modulates DNA Damage Response by Repressing Histone H2AX Expression (2023)

&lt;p&gt;PDF file - 1581K&lt;/p&gt;
An investigation into the effectiveness of heavy rollouts in UCT (2016)

General Intelligence in Game-Playing Agents (GIGA'16) Workshop at IJCAI'16, 9-15 July 2016, New York City, New York
Powder X-ray diffraction of azelastine hydrochloride, C 22 H 25 ClN 3 O·Cl (2020)

Commercial azelastine hydrochloride crystallizes in the monoclinic space group P 2 1/ n (#14) with a = 13.7844(5), b = 16.39920(14), c = 9.41231(22) Å, β = 97.5340(20)°, V = 2109.32(4) Å 3 , and Z = 4. The lattice parameters differ by −0.02, +0.04, and +0.04% from those in the previous determination (reflecting differences in the temperature and the sample source), and are more precise, from the use of synchrotron radiation. The experimental powder pattern is included in the Powder Diffraction File™ (PDF ® ) as entry 00-070-1219.
Robust Policy Learning over Multiple Uncertainty Sets (2022)

Reinforcement learning (RL) agents need to be robust to variations in safety-critical environments. While system identification methods provide a way to infer the variation from online experience, they can fail in settings where fast identification is not possible. Another dominant approach is robust RL which produces a policy that can handle worst-case scenarios, but these methods are generally designed to achieve robustness to a single uncertainty set that must be specified at train time. Towards a more general solution, we formulate the multi-set robustness problem to learn a policy robust to different perturbation sets. We then design an algorithm that enjoys the benefits of both system identification and robust RL: it reduces uncertainty where possible given a few interactions, but can still act robustly with respect to the remaining uncertainty. On a diverse set of control tasks, our approach demonstrates improved worst-case performance on new environments compared to prior methods based on system identification and on robust RL alone.
Here's the View From My Knothole (2021)

The author reflects on the state of U S public health amidst the coronavirus disease 2019 (COVID-19) pandemic as of February 2021 Topics include how the pandemic has transformed the school, workplace, and home environments, the strain and exhaustion experienced by Americans with social distancing, wearing mask and hygiene protocols, and the challenges faced by health workers in vaccination
Method of forming multi-leveled sequential patterns (2016)

The research is dedicated to the problem of large volumes of results acquired from sequential pattern mining. The new form of sequential patterns is proposed. The requirements for a programmed implementation of the described method are introduced. The results of experiments based on real malware behavior data are demonstrated.
Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells (2020)

Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a standardized photoreactor for visible light driven activation and photocatalytic chemical transformations. Using this single benchtop photoreactor, we perform photoredox reactions across multiple visible light wavelengths, a high throughput photocatalytic cross coupling reaction, and in vitro labeling of proteins and live cells. Given the success of this reactor in all tested applications, we envision that this multi-use photoreactor will be widely used in biology, chemical biology, and medicinal chemistry settings.
Raman gain flattening by using pump sources with different linewidths (2004)

Broadband Raman fibre amplifiers backward-pumped by sources with different linewidths are numerically studied for the first time. The approximation of the preliminary determined optimal continuous pump spectrum by four pump sources allowed the expansion of the spectral range of a 100-km Raman amplifier up to 1522–1596 nm with the gain ripple less than 0.2 dB. The pump scheme proposed in the paper is compared with schemes using pump sources with the same linewidths.
Genome analysis of C hitinivibrio alkaliphilus gen. nov., sp. nov., a novel extremely haloalkaliphilic anaerobic chitinolytic bacterium from the candidate phylum T ermite G roup 3 (2013)

Anaerobic enrichments from hypersaline soda lakes with chitin as substrate yielded five closely related anaerobic haloalkaliphilic isolates growing on insoluble chitin by fermentation at pH 10 and salinities up to 3.5 M. The chitinolytic activity was exclusively cell associated. To better understand the biology and evolutionary history of this novel bacterial lineage, the genome of the type strain ACht1 was sequenced. Analysis of the 2.6 Mb draft genome revealed enzymes of chitin-degradation pathways, including secreted cell-bound chitinases. The reconstructed central metabolism revealed pathways enabling the fermentation of polysaccharides, while it lacks the genes needed for aerobic or anaerobic respiration. The Rnf-type complex, oxaloacetate decarboxylase and sodium-transporting V-type adenosine triphosphatase were identified among putative membrane-bound ion pumps. According to 16S ribosomal RNA analysis, the isolates belong to the candidate phylum Termite Group 3, representing its first culturable members. Phylogenetic analysis using ribosomal proteins and taxonomic distribution analysis of the whole proteome supported a class-level classification of ACht1 most probably affiliated to the phylum Fibribacteres. Based on phylogenetic, phenotypic and genomic analyses, the novel bacteria are proposed to be classified as Chitinivibrio alkaliphilus gen. nov., sp. nov., within a novel class Chitinivibrione.
The patient is everything (2012)

When Deidre Criddle was announced as the Pharmaceutical Society of Western Australia's 2012 Eric Kirk Award winner in April no-one who knows her was in the least surprised. It was more a reaction of - good call! It's about time her work was recognised.
Synthesis of Reactive Intermediates for Natural Cyclopentane Derivatives from (−)‐Quinic Acid: Preparation of 11α‐hydroxy‐13‐oxaprostanoic acid (1981)

Abstract We describe a flexible, stereocontrolled synthesis of enantiomerically pure substituted cyclopentenes and cyclopentanes ‐ including 11α‐hydroxy‐13‐oxaprostanoic acid 20 ‐ (−)‐quinic acid via an acyclic precursor 6 by an intramolecular aldolisation‐dehydration reaction.
Supplementary Figure 3 from Reactivation of Suppressed RhoB is a Critical Step for the Inhibition of Anaplastic Thyroid Cancer Growth (2023)

Supplementary Figure 3 from Reactivation of Suppressed RhoB is a Critical Step for the Inhibition of Anaplastic Thyroid Cancer Growth
Attention-based active 3D point cloud segmentation (2010)

In this paper we present a framework for the segmentation of multiple objects from a 3D point cloud. We extend traditional image segmentation techniques into a full 3D representation. The proposed technique relies on a state-of-the-art min-cut framework to perform a fully 3D global multi-class labeling in a principled manner. Thereby, we extend our previous work in which a single object was actively segmented from the background. We also examine several seeding methods to bootstrap the graphical model-based energy minimization and these methods are compared over challenging scenes. All results are generated on real-world data gathered with an active vision robotic head. We present quantitive results over aggregate sets as well as visual results on specific examples.
Mechanical in-situ characterization of micro systems during encapsulation and integration processes in structural components (2016)

One of the present trends in microelectronic is the embedding of electronic devices directly into structural components. This integration of smart systems into hybrid and light weight structures also is a main objective of MERGE, the research cluster of excellence on Technologies for Multifunctional Lightweight Structures. The integrated silicon sensor system, also called stress monitor chip system (SMC), that allows health monitoring and failure detection in the hybrid structures is one of the MERGE demonstrators. It is capable of determining the magnitudes and the distribution of the mechanical load induced into electronics and sensor dies during embedding processes like encapsulation and moulding as well as afterwards in the service of the structural hybrid component. In the past years, the SMC system has already been shown to be highly accurate in stress monitoring during mechanical and thermal cyclic tests, in moisture swelling assessments and also during fabrication processes like transfer molding of Chip-on-Board (CoB) samples and epoxy underfilling of flip chip samples [1,2]. This paper investigates the individual process steps from the bare sensor chip up to the completion of the sensor integration in the lightweight structure regarding the induced mechanical stresses by using the SMC system.
High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil (2009)

HHV-8 is highly prevalent among recently HIV-1-infected subjects. Correlations with other sexually transmitted infections suggest common transmission routes.
TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition (2020)

Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription factors which belong to the p53 family, but their function and mechanism in CSCs remain elusive. Here, we investigated the role of TAp63α in colorectal CSCs and the effects of sulforaphane on TAp63α. We found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells. Overexpression of TAp63α promoted self-renewal capacity and enhanced CSC markers expression in colorectal sphere-forming cells. Furthermore, we showed that TAp63α directly bound to the promoter region of Lgr5 to enhance its expression and activate its downstream β-catenin pathway. Functional experiments revealed that sulforaphane suppressed the stemness of colorectal CSCs both in vitro and in vivo. Upregulation of TAp63α attenuated the inhibitory effect of sulforaphane on colorectal CSCs, indicating the role of TAp63α in sulforaphane suppression of the stemness in colorectal cancer. The present study elucidated for the first time that TAp63α promoted CSCs through targeting Lgr5/β-catenin axis and participated in sulforaphane inhibition of the stem cell properties in colorectal cancer.
A new skeletal muscle linear-pull energy convertor as a power source for prosthetic circulatory support devices [corrected]. (1992)

Previous studies show that stimulated skeletal muscle wrapped around the heart or a blood pumping pouch can provide partial circulatory assistance. However, skeletal muscle is accustomed to pulling in direct tension, and power obtained from using the muscle in wraparound configurations is very inefficient. Therefore we have developed a new skeletal muscle-powered, linear-pull energy convertor for powering a wide range of implanted devices, including circulatory support blood pumps such as counterpulsation devices or complete prosthetic ventricles. This energy convertor system is powered by a skeletal muscle such as the latissimus dorsi, which is stimulated with a pulse generator. With the muscle left intact and in situ as much as possible, its insertion at the humerus is removed and reattached to a small-cylinder hydraulic energy convertor that is firmly attached to the ribs. Mechanical force in direct tension from the muscle is converted to high-pressure, low displacement; hydraulic energy (at approximately 200 psi). The output of this hydraulic energy convertor is connected by a small-diameter tube to a hydraulic actuator to drive the pusher plate of an implantable ventricular assist device located in the thoracic cavity or abdomen or another suitable blood pump. Preliminary in vitro tests from an engineering model of the Thoratec muscle-powered ventricular assist device show flow outputs of 5.2 L/min at a mean arterial pressure of 99 mm Hg. The muscle-powered ventricular assist device is a specific application designed to provide completely implantable circulatory support as an alternative to heart transplantation. It will enable patients to experience a quality of life free from batteries and the electrical power-conditioning hardware required with electromechanical systems.
The botulinum toxin complex meets E-cadherin on the way to its destination (2011)

Botulinum neurotoxin (BoNT) causes the disease botulism, which is characterized by flaccid paralysis, in humans and animals. The metalloprotease activity of BoNT inhibits neurotransmitter release at neuro-muscular junctions. In most cases, poisoning occurs when BoNT is ingested. Therefore, BoNT must pass through the epithelial barrier of the gastrointestinal tract to enter the systemic circulation and reach the target site. BoNT forms large protein complexes by associating with non-toxic components referred to as non-toxic non-hemagglutinin (NTNH) and hemagglutinin (HA). These proteins protect BoNT from the low pH and proteases in the digestive tract. We recently determined that HA has an unexpected function of disrupting the intercellular epithelial barrier by directly binding to E-cadherin. HA binds to E-cadherin and disrupts its function in a species-specific manner, and this interaction is essential to disrupt tight junctions. This activity is thought to facilitate the absorption of BoNT through the paracellular route of the intestinal epithelium in susceptible species.
Solid-State Complexes of Hexafluoro-2-propanol with Benzophenone-Containing Polyimides (2001)

Films of benzophenone-containing polyimides were cast from hexafluoro-2-propanol (HFIP) solutions and vacuum-dried just above the HFIP boiling temperature (59 °C) until a constant weight was achieved. Upon heating, the films exhibited 15% weight loss beginning around 150 °C. Using infrared spectroscopy, it was determined that the evolved gas was HFIP, and it formed a hydrogen-bonded solid-state complex with the polyimide. The films still contained nearly 15% HFIP 18 months after casting, a testament to the room temperature stability of the complex. The HFIP-complexed polyimide films exhibited higher gas permeabilities and reduced selectivities compared to the same polyimide cast from dimethylformamide. These transport properties were attributed to plasticization of the polyimide by the HFIP, as evidenced by a reduced storage modulus and glass transition temperature compared to the uncomplexed polyimide.
<title>Molecular information from fluorescence spectroscopic investigations of breast tissues and tissue phantoms</title> (2002)

Polarized fluorescence spectroscopy in the visible range can be used to discriminate different types of human breast tissue, namely, malignant, benign and normal. The bandwidth of the 580nm band of the polarized spectra shows excellent discrimination among the different tissue types. This difference in the bandwidth of the 580nm band provides bio-molecular information of the breast tissues. The spatially dependent fluorescence spectra are recorded from different radial distances of the tissue sample. These spectral profiles show differences in broadening as one goes away from the excitation point. This broadening also provides information on the presence of porphyrin in the breast tissues. Various concentrations of two fluorophores with varying concentrations of scatterers have been studied based on the assumption that porphyrin plays a major role in progress of tumor. Correlations have been made with polarized fluorescence spectra as well as spatial profiles of fluorescence spectra of the different tissues with the measurements of tissue phantoms. Such correlations hint at porphyrin accumulation and scattering effects playing major roles in spectral differences among normal, benign and malignant tumor breast tissues.
Seasonal Variation in Penicillin Susceptibility and Invasive Pneumococcal Disease (2014)

We evaluated prospectively laboratory surveillance data from Massachusetts to investigate whether seasonal variation in invasive pneumococcal disease is associated with the proportion of penicillin-susceptible isolates. The proportion of penicillin-susceptible isolates associated with invasive pneumococcal disease varied by season, with proportions highest in the winter and lowest in the summer, and rates of invasive disease were highest in the autumn and winter seasons and lowest in the summer.
DCR current sensing method for achieving adaptive voltage positioning (AVP) in voltage regulators with coupled inductors (2006)

In microprocessor Voltage Regulators (VRs) with coupled inductors, the conventional DCR current sensing method doesn't work any more because of the current coupling effect among phases. A new DCR current sensing method for achieving Adaptive Voltage Positioning (AVP) in VRs with coupled inductors is proposed in this paper. The proposed DCR current sensing methods in VRs with two types of coupled inductors (integrated coupled inductors and center tap coupled inductors) are analyzed respectively in detail. After that, the current sharing of the coupled inductor VR with the proposed DCR current sensing method is analyzed. Finally, the proposed DCR current sensing method for achieving AVP in coupled inductor VRs is verified by the experimental results.
Dielectric-base transistors with doped channel (1997)

The dielectric-base transistor (DBT) is expected to be coupled with various functional oxides such as high-temperature superconductors and ferroelectrics. We experimented with lowering the conduction band of the channel to reduce the operating voltage. LaTiO3 deposited on SrTiO3 supplies carriers in the SrTiO3 substrate by displacing Sr2+ and La3+. With this technique, we fabricated a YBa2Cu3O7−x/In2O3/SrTiO3/LaTiO3/SrTiO3 transistor with a partially doped channel. The transistor operates at under 1 V while maintaining a voltage amplification factor of 2, which is one order smaller than the 15 V operating voltage of a transistor with an undoped channel. The base potential relative to the emitter conduction band has been reduced to 0.3 eV.
Synthesis and Biological Evaluation of N‐Substituted Indole Esters as Inhibitors of Cyclo‐Oxygenase‐2 (COX‐2). (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa (2023)

<i>Leptospira</i> was investigated in kidneys (<i>n</i> = 305) from slaughtered livestock in the Gauteng Province abattoirs, South Africa, using a culture medium to isolate <i>Leptospira</i>, followed by the <i>LipL32</i> qPCR to detect <i>Leptospira</i> DNA. The <i>SecY</i> gene region was amplified, sequenced, and analyzed for <i>LipL32</i> qPCR-positive samples or <i>Leptospira</i> isolates. The overall frequency of isolation of <i>Leptospira</i> spp. was 3.9% (12/305), comprising 4.8% (9/186), 4.1% (3/74), and 0% (0/45) from cattle, pigs, and sheep, respectively (<i>p</i> > 0.05). However, with <i>LipL32</i> qPCR, the overall frequency of <i>Leptospira</i> DNA was 27.5%, consisting of 26.9%, 20.3%, and 42.2% for cattle, pigs, and sheep, respectively (<i>p</i> = 0.03). Based on 22 <i>SecY</i> sequences, the phylogenetic tree identified the <i>L. interrogans</i> cluster with serovar Icterohaemorrhagiae and the <i>L. borgpetersenii</i> cluster with serovar Hardjo bovis strain Lely 607. This study is the first molecular characterization of <i>Leptospira</i> spp. from livestock in South Africa. The reference laboratory uses an eight-serovar microscopic agglutination test panel for leptospirosis diagnosis, of which <i>L. borgpetersenii</i> serovar Hardjo bovis is not part. Our data show that pathogenic <i>L. interrogans</i> and <i>L. borgpetersenii</i> are circulating in the livestock population. Diagnostic use of molecular methods will eliminate or reduce the under-reporting of leptospirosis in livestock, particularly sheep, in South Africa.
Specific Binding (In Dna-Protein Interactions) (2019)

Recommendations are given concerning the terminology of methods of bioanalytical chemistry. With respect to dynamic development particularly in the analysis and investigation of biomacromolecules, terms related to bioanalytical samples, enzymatic methods, immunoanalytical methods, methods used in genomics and nucleic acid analysis, proteomics, metabolomics, glycomics, lipidomics, and biomolecules interaction studies are introduced.
Francisco Rodríguez Marín (1855-1943), editor de "El Quijote" [IV Centenario de la publicación de El Qiujote] (2005)

Francisco Rodríguez Marín responde plenamente al término de polígrafo, puesto que su atención se dirigió a asuntos muy diversos, desde la edición de autores del Siglo de Oro, el folclore popular o la gastronomía. Hombre de una enorme erudición, trabajador incansable, hay que recordar su frase: “el gobierno en lugar de decretar el descanso dominical, debería decretar el trabajo semanal”, tuvo la suerte de vivir muchos años, aunque los últimos cuarenta sin apenas voz, algo que no le impidió seguir frecuentando a sus amigos y ostentar importantísimos cargos.