gebhart/patrepeval huggingface dataset:
A Rapid Viscous-Inviscid Interaction Method for the Preliminary Design of S-Shaped Transition Ducts (2021)

Abstract For preliminary design of compressor transition ducts, knowledge-based tools for the rapid assessment of aerodynamic performance of S-shaped ducts are not currently available in the open literature. This is due to the highly complex flow developing under the combined influence of pressure gradients and streamline curvature. This paper presents a new approach enabling an agile design process avoiding premature use of time-consuming high-fidelity CFD calculations. The features of a 2D axisymmetric incompressible steady flow field are captured with a semi-analytical viscous inviscid interaction method. A potential core, based on streamline curvature and implicit velocity profile by parametric spline reconstruction, is coupled to an integral method predicting the turbulent boundary layer growth up to separation. The shear stress distribution is generated by a modified mixing length model for strongly curved flows and wall shear stress closure is performed by inverse calculation of a composite law-of-the-wall. When compared to CFD, the aerodynamic loading is generally predicted to within ±3% but convergence is achieved 20 times faster.
Donor site morbidity following resection of the fibula (1990)

Ten adults were studied two to seven years after resection of a fibula for use as a free vascularised bone graft. Six had no symptoms in the donor leg, four had some aching, weakness or paraesthesia and three had definite weakness of the long toe flexors and extensors. All knees and ankles were clinically and radiologically stable, but the distal fibular remnant was osteoporotic in nine patients. Gait analysis of the donor leg and the contralateral normal leg showed definite differences, which could be attributed to weakness of the deep muscles caused by loss of their normal origin and to the change in load transmission through the fibula.
Design Requirements for the SNAP Telescope Structures (2000)

This document summarizes thermal, mechanical, stability, and other requirements and assumptions used by HYTEC in designing structural subsystems and components for the SNAP telescope. This is a working document; it is intended to be continuously updated and refined to reflect our best estimate of the baseline configuration and design requirements, and document the assumptions made in ini tial design studies. It should eventually evolve into a requirement document per se.
Creativity in Seventeen Syllables - Haiku for Learning (2017)

BRIEF SESSION DESCRIPTION: This session will offer the use of haiku poetry as a method for promoting creativity in the classroom as part of a mindfulness exercise. ________________________________________________________________ FULL ABSTRACT: In this session, I will demonstrate the use of haiku to promote creativity in thinking and discuss the role of creativity in learning theory. This process can be used as a mindfulness exercise to transform the learning environment from a structured focus to a rich more open-ended engaged thought process. In distance learning and the traditional classroom setting, students can compose a haiku in a few minutes with no prior experience, given a few guidelines. In my graduate-level capstone course at Mason, I use haiku writing as a way for students to think about their practice, characterizing their work as a vision-based calling instead of a series of tasks. Such creative mindfulness exercises take a constructivist approach useful in any discipline, including the social and physical sciences to help students step back from a linear daily world and into a more creative learning environment. We will spend most of the session crafting and sharing our haiku creations to demonstrate the simplicity of the activity, the creativity locked inside all of us, and the value of transformative critical thinking. In this session, I will provide learning-focused images and objects to prompt participants in haiku crafting and they will write about a specific moment in classroom learning. I will also provide a reference guide citing informing principles and specific resources. Teachers in virtually any discipline could use this as an opening exercise to transform minds from a digital world into deeper thinking about the topic of the day. In my experience in teaching a range of subjects from astronomy to conflict analysis and resolution, this technique would be of value, in my view.
Transcription Factor Mohawk and the Pathogenesis of Human Anterior Cruciate Ligament Degradation (2013)

Reduced expression of MKX is a feature of degenerated ACL in OA-affected joints, and this may be mediated in part by IL-1β. MKX appears necessary to maintain the tissue-specific cellular differentiation status and ECM production in adult human tendons and ligaments.
Synthetic vision - the display concept of the Collins team (2002)

The synthetic vision implementation discussed in this paper comprises elements in the navigation display, the vertical profile display and the primary flight display. The design rationale is provided based on an overview of the intended functions, options to implement these functions and the justifications used in the selection of a specific option.
Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways (2021)

Neutralizing antibodies (NAbs) strongly limit adeno-associated virus (AAV) vector transduction and repeated administration. Previous studies have shown that NAbs induced by AAVs are associated with T and B cell activation and that the B7/CD28 and CD40/CD40L costimulation signaling pathways are involved. Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and CD40 are vital molecules that participate in the costimulatory pathway. In this study, we evaluated CTLA4-Ig and CD40-Ig immunosuppreve efficacies through AAV and investigated their effects on the feasibility for multiple systemic administrations of AAV vectors. The results showed that a single administration of AAV vector carrying either CTLA4-Ig alone or with CD40-Ig could greatly reduce the level of NAbs. An AAV serotype-specific immune tolerance could be successfully established, which enabled repeated, that is, second and third, systemic administration of AAV vectors in the same mice. A combination of CTLA4-Ig and CD40-Ig delivered via AAV vectors significantly inhibited T and B cell activations without affecting the immune response to the total immunoglobulin G production and cytokines. Interestingly, exogenous gene expression significantly improved after multiple administrations of AAV vector <i>in vivo</i>. Our study generates a reliable and effective method for repeated dosing of AAV vectors that is needed on gene therapy.
If You Cannot Beat Them, Why Not Have Them Join Up? (2016)

This paper explores the plausibility of a rather novel solution to the problem of domestic terrorist threats: might the risk posed by individuals from communities that are thought to be prone to acts of political violence and terrorism be mitigated by recruiting to the military members of communities that public and political discourse has deemed a fifth pillar? The military presents a stable, well-paying career to individuals marginalized by their ethno-religious identity that have to this point been grossly under-represented in the Canadian Armed Forces. It can also bring members of these communities into a closer relationship with the state and mainstream society that will foster allegiance, combat alienation, and stifle the desire to commit violence against Canada and its citizens. Two implications follow for the Canadian Armed Forces from the explanation of the Toronto 18 as a non-peaceful node of an identity-based network. One is that the institution should be cautious not to fall into the trap of a populist vernacular reification of identity that might inadvertently further the community’s collective alienation by overtly appealing to “Arabs” or “Muslims”. The other is that the military may do well to focus on the equality of treatment within their institution rather than material benefits when attempting to extend an olive branch to Canada’s marginalized communities, instead making an emotional appeal based on the common good.
Improving Anesthesiologists’ Ability to Speak Up in the Operating Room (2015)

An educational intervention alone was ineffective in improving the speaking-up behaviors of practicing nontrainee anesthesiologists. Other measures to change speaking-up behaviors could be implemented and might improve patient safety.
Immunochemical characterization of two isoforms of rat liver ecto-ATPase that show an immunological and structural identity with a glycoprotein cell-adhesion molecule with Mr 105,000 (1991)

One of the cell-adhesion molecules (CAMs) responsible for rat hepatocyte aggregation has been described as a glycoprotein having an Mr of 105,000 (cell-CAM105). The Mr and localization of cell-CAM105 in liver membranes are very similar to those of liver ecto-ATPase, an ATPase with its nucleotide-hydrolysing site localized on the outside of the cell membrane. The protein sequence of the ecto-ATPase has been deduced from cDNA cloning. Structural analysis of the sequence indicates that the ecto-ATPase has immunoglobulin-like domains and is a member of the immunoglobulin superfamily. Since a group of proteins in the immunoglobulin superfamily has been shown to have functions related to cell adhesion, the structural characteristics of the ecto-ATPase further led to the possibility that the ecto-ATPase may have functions related to cell adhesion. In this paper, using the cDNA for the ecto-ATPase, the anti-peptide antibodies produced against peptides derived from the ecto-ATPase cDNA sequence and monoclonal antibodies against the cell-CAM105, we present evidence of identity between cell-CAM105 and ecto-ATPase. First, in Western immunoblots, two anti-cell-CAM105 monoclonal antibodies cross-reacted with the purified ecto-ATPase. Secondly, in immunodepletion experiments, antibodies against the ecto-ATPase depleted the same protein recognized by the anti-cell-CAM105 antibodies. Thirdly, in two-dimensional gel-electrophoretic analysis, anti-peptide antibodies generated against an extracellular N-terminal peptide and the intracellular C-terminal peptides of the ecto-ATPase immunoprecipitated proteins of similar isoelectric points and Mr values to those of the cell-CAM105. Fourthly, proteins immunoprecipitated by anti-ecto-ATPase antibodies and anti-cell-CAM105 antibodies have similar V8-proteinase-digest peptide maps. Finally, monoclonal antibodies against the cell-CAM105 specifically recognized the protein expressed in COS cells transfected with the ecto-ATPase cDNA. These results indicate that the ecto-ATPase cDNA codes for a protein that is identical with the cell-CAM105. Since the ecto-ATPase has structural features of immunoglobulin domains, the identity of cell-CAM105 with ecto-ATPase leads to the conclusion that this liver CAM, similarly to neuronal CAM, is also a member of the immunoglobulin supergene family. Furthermore, immunological studies indicate that the cell-CAM105/ecto-ATPase is composed of two isoforms of different C-terminal sequences. The association of ATPase activity with cell-CAM105 raises the possibility that extracellular nucleotides may play important roles in regulating cell adhesion.
Effects of Alar ligament transection on upper cervical spine rotation (1991)

Fresh human cadaveric specimens of occiput (C0) to C3 were subjected to axial torque. The resulting physiological motions were studied in an unconstrained three-dimensional manner. Effects of sequential transections of the left and right alar ligaments on the relative motions of C0-C1 and C1-C2 were studied. After transection of the left alar ligament, ranges of motion--due to 1.5 Nm torque--increased at both the C0-C1 and C1-C2 joints. Increases were small, on average 1.9 degrees to each side and at each level. Increases due to subsequent cutting of the right alar ligament were, on average, only 0.5 degrees and statistically not significant. In general, neutral zones showed greater increases, e.g., 3.9 degrees to each side at the C1-C2 joint. Comparing right and left axial rotations, after transection of the left alar ligament, showed greater percentage increases for the right, as compared to the left, axial rotation, at both C0-C1 and C1-C2 joints. Functional loss of the alar ligaments indicates a potential for rotatory instability, which, however, must be determined in conjunction with other clinical findings, such as neurological dysfunction, pain, and deformity.
EL SILENCIO Y LA PALABRA. ESTUDIOS SOBRE LA CIUDAD Y LOS PERROS, DE MARIO VARGAS LLOSA (2013)

Coincidiendo con la publicación en 2012 por parte de la Real Academia Española, en colaboración con la Asociación de Academias de la Lengua Española de la obra de Mario Vargas Llosa: La ciudad y los perros (edición conmemorativa del cincuentenario), la cátedra Mario Vargas Llosa de la Universidad de Málaga ha publicado, en este mismo año, una monografía colectiva titulada: El silencio y la palabra. Estudios sobre La ciudad y los perros de Mario Vargas Llosa.
The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia (2015)

Recent studies have revealed that cell competition can occur between normal and transformed epithelial cells; normal epithelial cells recognize the presence of the neighboring transformed cells and actively eliminate them from epithelial tissues. Here, we have established a brand-new high-throughput screening platform that targets cell competition. By using this platform, we have identified Rebeccamycin as a hit compound that specifically promotes elimination of RasV12-transformed cells from the epithelium, though after longer treatment it shows substantial cytotoxic effect against normal epithelial cells. Among several Rebeccamycin-derivative compounds, we have found that VC1-8 has least cytotoxicity against normal cells but shows the comparable effect on the elimination of transformed cells. This cell competition-promoting activity of VC1-8 is observed both in vitro and ex vivo. These data demonstrate that the cell competition-based screening is a promising tool for the establishment of a novel type of cancer preventive medicine.
The emerging role of transforming growth factor-beta in kidney diseases (1994)

Transforming growth factor-beta (TGF-beta) is a prototypical multifunctional cytokine, with growth being only one of its many functions. Its receptors and actions are germane to almost every cell in the body involved in tissue injury and repair, and its effects are best understood in the context of a cellular response to a changing environment. The broad areas in which TGF-beta plays a crucial role include cell proliferation and extracellular matrix production. TGF-beta is a key regulatory molecule in the control of the activity of fibroblasts and has been implicated in several disease states characterized by excessive fibrosis. In the kidney, TGF-beta promotes tubuloepithelial cell hypertrophy and regulates the glomerular production of almost every known molecule of the extracellular matrix, including collagens, fibronectin, tenascin, and proteoglycans, as well as the integrins that are the receptors for these molecules. Furthermore, TGF-beta blocks the destruction of newly synthesized extracellular matrix by upregulating the synthesis of protease inhibitors and downregulating the synthesis of matrix-degrading proteases such as stromelysin and collagenase. As will be discussed, there is a strong body of in vitro and in vivo evidence suggesting that persistent overproduction of TGF-beta 1 in glomeruli after the acute inflammatory stage of glomerulonephritis causes glomerulosclerosis. TGF-beta may also be important in a variety of other chronic renal disorders characterized by hypertrophy and sclerosis, such as diabetic nephropathy. In this review we will attempt to offer a basic understanding of the cellular and molecular biology of TGF-beta and its receptors, with special focus on the role of the TGF-beta system in the kidney during development, growth, and disease.
Potentially Preventable Hospitalizations and the Burden of Healthcare-Associated Infections (2017)

Clinical implications include increased risk of HAI among diabetic patients admitted for lower extremity amputation. Methodological implications include identification of rare events for inpatient subpopulations and the need for improved codification of HAIs to improve cost and policy analyses regarding allocation of resources toward clinical improvements.
Characterization of the shrimp eyestalk cDNA encoding a novel fushi tarazu‐factor 1 (FTZ‐F1)1 (1999)

To study the role of ecdysone and the ecdysone inducible gene in the regulation of molting and development in crustaceans, we have cloned a cDNA encoding an orphan nuclear receptor family member from the eyestalk of the shrimp Metapenaeus ensis. The size of the cDNA is 4.3 kb with the longest open reading frame (ORF) encoding a protein of 545 amino acid residues. The deduced amino acid sequence of the shrimp cDNA consists of regions that are characteristic of those of the nuclear hormone receptors. It shows a high degree of amino acid sequence identity in the DNA binding domain, ligand binding domain and the FTZ box as compared to those of invertebrates and vertebrates. Unlike the insects Drosophila melanogaster and Bombyx mori, an AF2 transactivation domain was present in the shrimp FTZ-F1. Northern blot analysis using total RNA indicated that the FTZ-F1 mRNA could also be detected in the mature ovary. Northern blot analysis and RT-PCR analysis showed that the shrimp FTZ-F1 transcripts could be detected in the ovary, newly hatched nauplius, testis, eyestalk and epidermis of the adult shrimp. Although the cDNA clone was isolated from the eyestalk library, the shrimp FTZ-F1 appeared to express most abundantly in the mature oocytes. The presence of abundant FTZ-F1 specific maternal message in the late vitellogenic ovary and early nauplius indicates that it may be important for the early embryonic and larval development of the shrimp. Interestingly, shrimp FTZ-F1 can also be found in testis of the male shrimp. The presence of FTZ-F1 in other tissues such as epidermis suggests that it may also be involved in other physiological processes such as molting.
Grid Independent Task Scheduling Multi-Objective Optimization Model and Genetic Algorithm (2010)

The characteristic of heterogeneous grid environment results in that the task scheduling is constrained by a number of factors such as the length of scheduling, the performance of security, and the cost of scheduling , etc. Firstly, under the consideration of the task scheduling demand for secure performance. A security benefit function and the corresponding time cost model are constructed. Secondly , according to the past behavior of grid resource nodes, a simple and efficient node’s credibility dynamic evaluation model is built by using the weighted function. Thirdly, b ased on these, a new constrained multi-objective grid task scheduling mode is proposed. In order to solve this model, the relationship between the characteristic of the task and the different performance among nodes is used to define the individual relationship matrix; then the subjection degree function is used to transform each relationship matrix into a fuzzy matrix . A ccording to the different effects of each objective in the final objective , each weight in the final decision-making is determined. By doing so, the multi-objective model is transformed into a single-objective model. Through the design of new crossover operator and an uniform mutation operator, a genetic algorithm called MUGA for the transformed problem is proposed. Finally, s imulation results show that the proposed algorithm is better than the compared ones in terms of the length of the task scheduling, security efficiency value, reliability and scheduling costs.
Supplementary Figure S1 from RNA Interference Using <i>c-Myc</i>–Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models (2023)

&lt;p&gt;Supplementary Figure S1: TEM, size and zeta potential analysis of the nanoparticles&lt;/p&gt;
Multi-view Aggregation for Color Naming with Shadow Detection and Removal (2018)

This paper presents a set of methods for classifying the color attribute of objects when multiple images of the same objects are available. This problem is more complex than the single image estimation since varying environmental effects, such as, shadows or specularities from light sources, can result in poor accuracy. These depend primarily on the camera positions and the material type of the objects. Single image techniques focus on improving the discrimination of between colors, whereas in multi-view systems additional information is available but should be utilized wisely. To this end, we propose three methods to aggregate image pixel information in multi-view that boost the performance of color name classification. Moreover, we study the effect of shadows by employing automatic shadow detection and correction techniques on the color naming problem. We tested our proposals on a new multi-view color names dataset (M3DCN) which contain indoor and outdoor objects. The experimental evaluation shows that one out of the three presented aggregation methods is very efficient and it achieves the highest accuracy in term of classification results. Also, we experimentally show that addressing visual outliers like shadow in multi-view images improves the performance of the color attribute decision process.
Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression (2021)

Neuroendocrine prostate cancer (NEPrCa) arises de novo or after accumulation of genomic alterations in pre-existing adenocarcinoma tumors in response to androgen deprivation therapies. We have provided evidence that small extracellular vesicles released by PrCa cells and containing the αVβ3 integrin promote neuroendocrine differentiation of PrCa in vivo and in vitro. Here, we examined αVβ3 integrin expression in three murine models carrying a deletion of PTEN (SKO), PTEN and RB1 (DKO), or PTEN, RB1 and TRP53 (TKO) genes in the prostatic epithelium; of these three models, the DKO and TKO tumors develop NEPrCa with a gene signature comparable to those of human NEPrCa. Immunostaining analysis of SKO, DKO and TKO tumors shows that αVβ3 integrin expression is increased in DKO and TKO primary tumors and metastatic lesions, but absent in SKO primary tumors. On the other hand, SKO tumors show higher levels of a different αV integrin, αVβ6, as compared to DKO and TKO tumors. These results are confirmed by RNA-sequencing analysis. Moreover, TRAMP mice, which carry NEPrCa and adenocarcinoma of the prostate, also have increased levels of αVβ3 in their NEPrCa primary tumors. In contrast, the αVβ6 integrin is only detectable in the adenocarcinoma areas. Finally, analysis of 42 LuCaP patient-derived xenografts and primary adenocarcinoma samples shows a positive correlation between αVβ3, but not αVβ6, and the neuronal marker synaptophysin; it also demonstrates that αVβ3 is absent in prostatic adenocarcinomas. In summary, we demonstrate that αVβ3 integrin is upregulated in NEPrCa primary and metastatic lesions; in contrast, the αVβ6 integrin is confined to adenocarcinoma of the prostate. Our findings suggest that the αVβ3 integrin, but not αVβ6, may promote a shift in lineage plasticity towards a NE phenotype and might serve as an informative biomarker for the early detection of NE differentiation in prostate cancer.