gebhart/patrepeval huggingface dataset:
Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma (2015)

miR-223 regulates STMN1 in MPM, and both are in turn regulated by the JNK signaling pathway. As such, miR-223 and STMN1 play an important role in regulating MPM cell motility and may be therapeutic targets.
Automated quantitative coronary arteriography: morphologic and physiologic validation in vivo of a rapid digital angiographic method. (1987)

Quantitative coronary arteriography has been shown to be useful in assessing the extent of coronary disease, its functional significance, and its response to therapeutic interventions. Most current methods rely either on hand-drawn arterial contours or automatic edge-detection algorithms applied to 35 mm cineangiograms. To assess the performance in vivo of a new, fully automatic, rapid coronary quantitation program, dogs were instrumented with precision-drilled, plastic cylinders to create intraluminal stenoses in the left anterior descending and/or circumflex arteries, as well as with high-fidelity micromanometers and electromagnetic flow probes. Stenosis diameters ranged from 0.83 to 1.83 mm. Biplane, on-line, digital coronary angiograms and cineangiograms were recorded during standard selective coronary arteriography in the closed-chest preparation. The on-line digital images were analyzed in nonsubtracted and subtracted modes. Cineangiograms were digitized to allow coronary quantitation by the same computer program. There was an excellent correlation between known and measured minimal diameter stenoses (r = .87 to .98, SEE = 0.09 to 0.24 mm). Interobserver and intraobserver variability analysis showed high reproducibility (r = .90 to .97, SEE = 0.12 to 0.23 mm). The best results in both analyses were achieved by nonsubtracted digital imaging and the worst by cineradiography. Measures of percent diameter stenosis, percent area stenosis (geometric and videometric), and absolute minimal cross-sectional area (geometric and videometric) were all significantly correlated with independent measures of actual coronary flow reserve. This study provides direct anatomic and physiologic validation in vivo of a new and rapid coronary quantitation method suitable for analysis of both digital angiograms and cineangiograms.
Adaptive Step Size Gradient Ascent ICA Algorithm for Wireless MIMO Systems (2018)

Independent component analysis (ICA) is a technique of blind source separation (BSS) used for separation of the mixed received signals. ICA algorithms are classified into adaptive and batch algorithms. Adaptive algorithms perform well in time-varying scenario with high-computational complexity, while batch algorithms have better separation performance in quasistatic channels with low-computational complexity. Amongst batch algorithms, the gradient-based ICA algorithms perform well, but step size selection is critical in these algorithms. In this paper, an adaptive step size gradient ascent ICA (ASS-GAICA) algorithm is presented. The proposed algorithm is free from selection of the step size parameter with improved convergence and separation performance. Different performance evaluation criteria are used to verify the effectiveness of the proposed algorithm. Performance of the proposed algorithm is compared with the FastICA and optimum block adaptive ICA (OBAICA) algorithms for quasistatic and time-varying wireless channels. Simulation is performed over quadrature amplitude modulation (QAM) and binary phase shift keying (BPSK) signals. Results show that the proposed algorithm outperforms the FastICA and OBAICA algorithms for a wide range of signal-to-noise ratio (SNR) and input data block lengths.
Mucocutaneous manifestations in 150 HIV-infected Indian patients and their relationship with CD4 lymphocyte counts (2009)

Mucocutaneous findings in 150 HIV+ve cases (F, 79; M, 71) were evaluated over a one-year period. Mucocutaneous manifestations were seen in 96% with 2.9 mean number of dermatoses and mean cluster of differentiation (CD4) count of 196.33 cells/mm(3). The highest number of mean dermatoses, 3.29, was seen in individuals with severe immunosuppression. The most common mucocutaneous manifestation seen was candidiasis (35.33%), followed by seborrhoeic dermatitis (31.33%), oral pigmentation (29.33%), xerosis/ichthyosis (22.67%), pyodermas (22%), periodontitis (17.33%) and nail pigmentation (16.67%). Patient stratification according to the WHO immunological staging, according to CD4 counts, showed a statistically significant association (P < 0.05) for candidiasis, scabies, paronychia, oral pigmentation and diffuse hair loss. Nail and oral pigmentary changes, trichomegaly and subcutaneous fungal infections caused by dermatophytes were highlights of the study. Incidences of xerosis/ichthyosis, pyodermas, scabies and molluscum contagiosum reported in our study were higher and pruritic popular eruptions was lower than those in previous Indian studies. Cutaneous neoplasms were not seen in the present study.
Alkoxy‐substituted diaryliodonium salt cationic photoinitiators (1989)

Abstract This paper describes the synthesis and characterization of a series of (4‐alkoxyphenyl)phenyliodonium salts which are excellent photo‐ and thermal‐initiators for the cationic polymerization of vinyl and heterocyclic monomers. These compounds are easily prepared by straightforward synthetic techniques and display very good solubility and photoresponse characteristics which make them especially attractive for use in UV curing applications. Those compounds with alkoxy chains of eight carbons and longer are essentially nontoxic.
Evaluation of environmentally conscious product designs (1998)

Design-for-retirement is a concept that allows one to design a product such that its retirement time and post-life treatment are optimized, i.e., its environmental impact is minimized and financial gain is maximized. Retired products face four primary multilifecycle engineering treatments: 1) to recondition for reuse in the next lifecycle; 2) to convert into a material form for recycling back into new parts, 3) to disassemble into several components for further assessment and 4) to landfill. Each option has a different environmental cost-benefit ratio. This paper proposes several matrices to represent the connection information, interference directions among nodes, and disassembly complexity. It presents a method to evaluate a design in terms of cost and apply it to two personal computer designs.
A weakness in Sun-Chen-Hwang's three-party key agreement protocols using passwords. (2004)

Recently, Sun, Chen and Hwang [J. Syst. Software, 75 (2005), 63–68] have proposed two new three-party protocols, one for password-based authenticated key agreement and one for verifier-based authenticated key agreement. In this paper, we show that both of Sun-Chen-Hwang’s protocols are insecure against an active adversary who can intercept messages, start multiple sessions of a protocol, or otherwise control the communication in the network. Also, we present a simple solution to the security problem with the protocols.
Isolation and Characterization of the RNA2, RNA3, and RNA11 Genes of Saccharomyces cerevisiae (1984)

Temperature-sensitive mutations in the genes RNA2 through RNA11 cause accumulation of intervening sequence containing precursor mRNAs in Saccharomyces cerevisiae. Three different plasmids have been isolated which complement both the temperature-sensitive lethality and precursor mRNA accumulation when introduced into rna2, rna3, and rna11 mutant strains. The yeast sequences on these plasmids have been shown by Southern transfer hybridization and genetic mapping to be derived from the RNA2, RNA3, and RNA11 genomic loci. Part of the RNA2 gene is homologous to more than one region of the yeast genome, whereas the RNA3 and RNA11 genes are single copy. RNAs homologous to these loci have been identified by RNA transfer hybridization, and the specific RNAs which are associated with the Rna+ phenotype have been mapped. This was done by a combination of transcript mapping, subcloning, and in vitro mutagenesis. The transcripts are found to be enriched in polyadenylated RNA and are of very low abundance (0.01-0.001% polyadenylated RNA).
Transport of lactate and other short-chain monocarboxylates in the yeast Saccharomyces cerevisiae (1987)

Saccharomyces cerevisiae IGC4072 grown in lactic acid medium transported lactate by an accumulative electroneutral proton-lactate symport with a proton-lactate stoichiometry of 1:1. The accumulation ratio measured with propionate increased with decreasing pH from ca. 24-fold at pH 6.0 to ca. 1,400-fold at pH 3.0. The symport accepted the following monocarboxylates (Km values at 25 degrees C and pH 5.5): D-lactate (0.13 mM), L-lactate (0.13 mM), pyruvate (0.34 mM), propionate (0.09 mM), and acetate (0.05 mM), whereas apparently a different proton symport accepted formate (0.13 mM). The lactate system was inducible and was subject to glucose repression. Undissociated lactic acid entered the cells by simple diffusion. The permeability of the plasma membrane for undissociated lactic acid increased exponentially with pH, and the diffusion constant increased 40-fold when the pH was increased from 3.0 to 6.0.
An Interval Analysis Based Study for the Design and the Comparison of Three-Degrees-of-Freedom (2014)

This paper addresses an interval analysis based study that is applied to the design and the comparison of three-degrees-of-freedom (3-DoF) parallel kinematic machines. Two design criteria are used: (i) a regular workspace shape and (ii) a kinetostatic performance index that needs to be as homogeneous as possible throughout the workspace. The interval analysis based method takes these two criteria into account; on the basis of prescribed kinetostatic performances, the workspace is analyzed to find the largest regular dextrous workspace enclosed in the Cartesian workspace. An algorithm describing this method is introduced. Two 3-DoF translational parallel mechanisms designed for machining applications are compared using this method. The first machine features three fixed linear joints which are mounted orthogonally and the second features three linear joints which are mounted in parallel. In both cases, the mobile platform moves in the Cartesian x--y--z space with fixed orientation.
Angular limit for coronal joint deformity correction using intramedullary guidance in total knee arthroplasty. A pilot study (2020)

Our results suggest that the bony correction obtained via IM guiding depends exclusively on the primary deformation of the tibia. In cases of a varus of more than 94°, the IM guide was found to yield sub-optimal corrections. Thus, other solutions need to be investigated.
Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials (2014)

Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured parasites in the presence of a representative member of the aminopyrazole series, GNF-Pf4492, to select for resistance. Whole genome sequencing of three resistant lines showed that each had acquired independent mutations in a P-type cation-transporter ATPase, PfATP4 (PF3D7_1211900), a protein implicated as the novel Plasmodium spp. target of another, structurally unrelated, class of antimalarials called the spiroindolones and characterized as an important sodium transporter of the cell. Similarly to the spiroindolones, GNF-Pf4492 blocks parasite transmission to mosquitoes and disrupts intracellular sodium homeostasis. Our data demonstrate that PfATP4 plays a critical role in cellular processes, can be inhibited by two distinct antimalarial pharmacophores, and supports the recent observations that PfATP4 is a critical antimalarial target.
Soft X-Ray Critical-Angle Transmission Grating Spectrometer for the International X-Ray Observatory (2009)

See also http://space.mit.edu/home/dph/ixo/ (IXO/CAT-GS Development) http://snl.mit.edu/ (Space Nanotechnology Laboratory) ABSTRACT: We have developed a new type of soft x-ray diffraction grating. This critical-angle transmission (CAT) grating [1-4] combines the advantages of traditional transmission gratings (very low mass, extremely relaxed alignment and flatness tolerances) with those of x-ray reflection gratings (high efficiency due to blazing in the direction of grazing-incidence reflection). In addition, grating spectrometers based on CAT gratings are well-suited for co-existence with high-energy focal plane microcalorimeter detectors as planned for the International X-Ray Observatory, since most high-energy x rays are undeflected and arrive at the telescope focus. We have previously micro-fabricated 574 and 200 nm-period prototypes of the smooth, high-aspect ratio, and sub-micron period structures necessary for efficient CAT gratings through interference lithography, anisotropic etching of silicon crystals, and critical-point drying. X-ray test have demonstrated high-efficiency blazing in accordance with theoretical predictions. We will describe the CAT grating principle and design, fabrication, and x-ray efficiency measurements, and discuss various high-resolution (E/ΔE ~ 5000), high-effective area (up to 10,000 cm2) implementations for a CAT grating spectrometer.
Nondestructive assessment of beef-marbling grade using hyperspectral imaging technology (2011)

The objective of this study was to assess the beef-marbling grade using hyperspectral imaging technology. A hyperspectral scanning imaging system was developed to collect hyperspectral images in the spectral region of 400-1100 nm. Original turned line-scanning hyperspectral images were transformed into three-dimensional spectral data with a computer program developed by authors. The maximal ratio of gray value of fat and lean in each band was used to select characteristic bands. As a result, the images at 530nm were used to differentiate beef-marbling. Three characteristic parameters were extracted, and used to establish prediction model by multiple linear regression (MLR) methods. The MLR model gave a good result with R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.92, SE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CV</sub> = 0.45. The research demonstrated that hyperspectral imaging technology is useful for nondestructive determination of beef marbling level.
Thermochromism in copper(II) complexes. Structures of the red and blue-violet forms of bis(N,N-diethylethylenediamine)copper(II) perchlorate and the nonthermochromic violet bis(N-ethylethylenediamine)copper(II) perchlorate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermochromism in copper(II) complexes. Structures of the red and blue-violet forms of bis(N,N-diethylethylenediamine)copper(II) perchlorate and the nonthermochromic violet bis(N-ethylethylenediamine)copper(II) perchlorateI. Grenthe, P. Paoletti, M. Sandstroem, and S. GlikbergCite this: Inorg. Chem. 1979, 18, 10, 2687–2692Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://doi.org/10.1021/ic50200a010RIGHTS & PERMISSIONSArticle Views1882Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (742 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Orthotopic Xenograft Model of Cervical Cancer for Studying Microenvironmental Effects on Metastasis Formation and Response to Drug Treatment (2011)

Cancers arising in the uterine cervix are usually squamous cell carcinomas that develop from preneoplastic lesions. They invade locally, and then typically metastasize to the regional lymph nodes and eventually to distant sites. Orthotopically grown xenografts are technically challenging to perform, but recapitulate the clinical situation to a greater extent than xenografts grown at subcutaneous or intramuscular sites. Thus, orthotopic xenografts develop lymphovascular invasion and metastasize to the para-aortic lymphatic chain in a pattern similar to that seen in patients. The extent of (lymph node) metastases is particularly apparent when the implanted tumor cells are transfected to express a fluorescent marker, such as DsRed, which allows the exposed retroperitoneum to be examined by fluorescence microscopy. Described in this unit is a surgical technique for orthotopic implantation and the use of this model for investigating the effects of novel agents as inhibitors of tumor growth and metastasis.
Does 𝓿 Cep indicate a non-axisymmetric dynamo? (1986)

Abstract According to observations of Scholz and Gerth the super-giant 𝓿 Cep has a magnetic field with a maximum field strength up to 2500 Gauss. This field shows a period of about 5 years. It is unplausible that this magnetic field is a relic since 𝓿 Cep was formed by expansion of a B-star. We claim here that 𝓿 Cep represents a dynamo exciting a magnetic field which in the average strongly deviates from symmetry about the rotation axis.
Microscopic Fluorescence Studies on Brain Intracellular Ca2+ Responses to Ischemia with and without Ca2+- Channel Blockade (2006)

This study presents the experimental results of intracellular calcium responses to ischemia with and without calcium channel blockade with nimodipine in the brain using fluorescence microscopic imaging.
Portable top drive cuts horizontal drilling costs (1993)

Economic analysis of a seven-well, long-reach horizontal drilling program into an unconsolidated, heavy-oil-bearing reservoir in Winter field near the Alberta/Saskatchewan border in Canada reveals that -- in the right application -- renting a portable top drive drilling system can reduce total drilling costs. Use of the portable top drive combined with other cost-saving measures enabled Saskoil, one of Canada`s larger independents, to drill more cheaply, on a cost-per-meter basis, in 1993 than in 1992. This was despite significant rental rates for drilling rigs and directional drilling services caused by increased demand in Western Canada. Total cost savings of 10% on wells that would otherwise cost in the (C) $500,000 range are believed realistic. Based on this year`s performance, Saskoil recommends top drive for the company`s future horizontal wells in this area. This article describes the operator`s horizontal well program, advantages of top drive in that program and how it was installed and applied. Estimated time savings for six wells, plus other ways top drive can cut costs and improve operations are discussed.
“PADA ZAMAN ITU TIDAK ADA RAJA DI ANTARA ORANG ISRAEL” DALAM HAKIM-HAKIM 17 – 21: (2012)

Artikel ini membahas tentang tema yang diusung dalam kelima pasal terakhir dari kitab Hakim-hakim. Kelima pasal ini berikut tema yang diusung seringkali dilihat sebagai sebuah tambahan atau sisipan yang tidak memiliki hubungan yang kuat dengan tema dari kitab Hakim-hakim. Penulis melalui artikel ini hendak menunjukkan bahwa tema yang diusung dalam kelima pasal terakhir ini bukan hanya merupakan satu kesatuan dengan seluruh kitab, malah justru menjadi tema utama dari kitab Hakim-hakim karena tema ke-raja-an adalah tema yang lebih populer dan mendominasi dalam bahasan kitab nabi awal (former prophet) dibanding dengan topik tentang “hakim.” “Tidak ada raja di Israel” justru menjadi jawaban yang sangat erat terkait dengan lingkaran kesesatan yang seringkali dilihat sebagai tema dalam kitab Hakim-hakim. Dengan struktur sebagai akhiran atau ending, maka tema yang diusung di kelima pasal terakhir ini merupakan kesimpulan yang merangkum seluruh berita dalam kitab Hakim-hakim pada akhirnya.
CXLIX.—Dihydrocinnamenylcarbimide (β-phenylethyl isocyanate) (1911)

M. O. Forster and H. Stötter, J. Chem. Soc., Trans., 1911, 99, 1337 DOI: 10.1039/CT9119901337
Crystallization of a novel esterase which inactivates the macrolide toxin brefeldin A (1996)

A novel esterase obtained from Bacillus subtilis and capable of hydrolyzing the phytotoxin brefeldin A was crystallized using the hanging-drop technique. The crystals have two forms and both are monoclinic: form I, space group P2(1) with a = 101.7, b = 64.1, c = 55.4 A and beta = 102.5 degrees, and form II, space group C2 with a = 140.7, b = 82.6, c = 81.5 A and beta = 112.5 degrees. There are two molecules related by a pronounced non-crystallographic dyad per asymmetric unit in both crystal forms. The crystals diffract to 2.3 A using a rotating-anode X-ray source.
The Reaction of Cyclopolyphosphines with Boron Halides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Cyclopolyphosphines with Boron HalidesA. H. Cowley and R. P. PinnellCite this: Inorg. Chem. 1966, 5, 8, 1463–1464Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/ic50042a045https://doi.org/10.1021/ic50042a045research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multicore Erbium Doped Fiber Amplifiers for Space Division Multiplexed System (2013)

We report on recent development of core-and cladding-pumped multicore fiber amplifiers suitable for amplifying space division multiplexed signals. Amplification, noise properties of these amplifiers are shown, and scopes for further development will be discussed.
c-Met activation leads to the establishment of a TGF-B receptor regulatory network required for bladder cancer invasion (2018)

No Abstract Available