gebhart/patrepeval huggingface dataset:
Sensitivity of mononuclear cells to PUVA: effect on subsequent stimulation with mitogens and on exclusion of trypan blue dye (1981)

Journal Article Sensitivity of mononuclear cells to PUVA: effect on subsequent stimulation with mitogens and on exclusion of trypan blue dye Get access WARWICK L. MORISON, WARWICK L. MORISON Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114 Search for other works by this author on: Oxford Academic Google Scholar JOHN A. PARRISH, JOHN A. PARRISH Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114 Search for other works by this author on: Oxford Academic Google Scholar DANIELJ. MCAULIFFE, DANIELJ. MCAULIFFE Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114 Search for other works by this author on: Oxford Academic Google Scholar KURT J. BLOCH KURT J. BLOCH Clinical Immunology and Allergy Units of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114 Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 6, Issue 3, 1 May 1981, Pages 273–277, https://doi.org/10.1111/j.1365-2230.1981.tb02303.x Published: 01 May 1981 Article history Accepted: 12 June 1980 Published: 01 May 1981
Magnetic field shielding project. Final report (1998)

Magnetic field management research at EPRI has had three major components: transmission, distribution, and shielding. Shielding people and equipment from 60-Hz magnetic fields provided a particularly challenging objective. Although much was known and the science was well developed for shielding radio frequency fields, little was known about shielding power frequency fields. EPRI mounted a large research effort that reviewed basic principles; developed theory and practice; performed tests and verifications; and produced software and guides for design of effective shields.
Stationary characteristics in bipolar diffusion charging of aerosols: Improving the performance of electrical mobility size spectrometers (2018)

Stationary characteristics in bipolar diffusion charging of aerosols: Improving the performance of electrical mobility size spectrometers
Current and Future Trends in Using MS for Microbial Detection and Identification (2013)

One of the main issues of any biological detection method is how do you collect the microbes. In the case of fungi, you can generally see the fruiting body and so you collect it into a pouch and move on; in the case of fungal hyphae, fungal spores, and the fungi imperfecti, also known as the Deuteromycota, the problem of collection becomes complex. Added to this, the bacteria and then the viruses and the sampling and collection methods suddenly become important to any method designed to detect and identify them.
Four wave mixing based wavelength conversion and multicasting of 16-QAM signals in a silicon nanowire (2013)

We demonstrate error-free wavelength conversion of 16-QAM 28-GBaud (112 Gb/s) signals and 1-to-6 wavelength multicasting of 16-QAM 22-GBaud (6×88 Gb/s) signals based on four wave mixing in a dispersion engineered silicon nanowire.
Interference Localization using a Controlled Radiation Pattern Antenna (CRPA) (2016)

The need to ensure the continuous availability of Global Navigation Satellite Systems (GNSS) continues to increase along with the implementation of PBN and ADS-B. For this purpose, a Radio Frequency Interference (RFI) Mitigation Plan is being developed by Eurocontrol, which includes a comprehensive set of preventive and reactive measures to limit vulnerability to RF interference. Among the reactive measures is the need to be able to detect, locate and eliminate an RFI source in a timely and efficient manner. A cooperative concept is foreseen for this purpose, where aerial capabilities aim to quickly identify the approximate location of an RFI source. This should allow dispatching ground measurement vehicles to a limited search area, ensuring a good chance that the precise location of the source can be identified and lead to successful enforcement action. Limiting the time of exposure to an RFI source will then make an important contribution to mitigating GNSS vulnerability to RFI. However, currently, only very few flight inspection or other aerial work platforms are equipped with RFI localization capabilities with the sensitivity required to detect GNSS interference sources. Another problem is that if an aircraft flies into an area of GNSS interference, its own positioning capability may be impacted, affecting both aircraft navigation and the ability to fix the position of RFI sources. In order to both maintain ownship position while looking for RFI sources and improve the speed and accuracy of RFI source localization capabilities, the use of a GNSS CRPA is being evaluated. A CRPA is a Controlled Radiation Pattern Antenna, which can dynamically modify the gain pattern and either form beams of positive gain towards the satellite signals being received, or steer nulls (negative gain) towards the interference sources. The CRPA is expected to both preserve GNSS positioning while also providing at least an azimuth angle towards the source of the interference. If the latter is integrated with an AHRS (Attitude and Heading Reference System), only a few lines of position pointing towards the RFI source could provide a fast indication of the probable ground location. The paper will present the results of the conducted technical studies and test campaigns. Concept validation so far mainly includes laboratory simulations using a wavefront simulator, and open air tests using a moving van platform. An overflight with a flight inspection aircraft using a non-GNSS specific localization capability was conducted as well. The paper will discuss system integration challenges, operational concepts and provide results in terms of system sensitivity to typical RFI sources and angular accuracy.
The Gut Microbiota and its Contribution to Homeostasis (2010)

This chapter contains sections titled: Introduction Characteristics of the Gastrointestinal Microbiota The Symbiosis of the Gut Microbiota and the Host Conclusion Abbreviations References
Self-coherent reflective FDMA-PON for next generation access and LAN architectures (2015)

In this paper we will give an insight to the FABULOUS European Project, pertaining to the 7 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> Framework Program, showing a self-coherent passive optical network that employs Frequency Division Multiplexing and is compatible with legacy infrastructures and NG-PON2 power budget specifications, while exceeding them in terms of bit-rate. FABULOUS also envisions an innovative Optical Network Unit, based on a reflective Mach-Zehnder modulator, that is suitable for full integration in silicon-photonics, for realizing low-cost customer premises equipment, indispensable for a massive deployment of the solution. The novelty of this work compared to previous papers in the same areas is in focusing on different possible applications having different physical layer requirements, including the recent trend that propose high-capacity PON as an alternative solution for next-generation Local Area Network.
Electromagnetic induction by a finite electric dipole source over a 2-D earth (1993)

Abstract A numerical solution for the frequency domain electromagnetic response of a two-dimensional (2-D) conductivity structure to excitation by a three-dimensional (3-D) current source has been developed. The fields are Fourier transformed in the invariant conductivity direction and then expressed in a variational form. At each of a set of discrete spatial wavenumbers a finite-element method is used to obtain a solution for the secondary electromagnetic fields. The finite element uses exponential elements to efficiently model the fields in the far-field. In combination with an iterative solution for the along-strike electromagnetic fields, this produces a considerable reduction in computation costs. The numerical solutions for a horizontal electric dipole are computed and shown to agree with closed form expressions and to converge with respect to the parameterization. Finally some simple examples of the electromagnetic fields produced by horizontal electric dipole sources at both the seafloor and air-earth interface are presented to illustrate the usefulness of the code.
A Miniature Composite Energy Harvesting System for Wireless Sensor Nodes (2012)

A prototype of composite energy generator applied in wireless sensor nodes was designed and implemented.Based on a wireless magnetic traffic flow sensor,the design target was defined.Solar energy,wind energy and strain energy were selected as the ambient energy source.According to the features of the three sources,energy management module and energy storage module were designed.The prototype was implemented and tested.The experimental results show that the prototype can continuously supply 50 mW output power at 3.55 V for 35 h.
Book Review A Dictionary of Natural Products, by George Macdonald Hocking, Plexus Publishing, Inc., 143 Old Marlton Pike, Medford, NJ 08055, USA, $139.50, 994 pp., 1997 (1998)

(1998). Book Review A Dictionary of Natural Products, by George Macdonald Hocking, Plexus Publishing, Inc., 143 Old Marlton Pike, Medford, NJ 08055, USA, $139.50, 994 pp., 1997. Pharmaceutical Biology: Vol. 36, No. 3, pp. 233-233.
Inhibition of Myocardial Apoptosis as a Therapeutic Target in Cardiovascular Disease Prevention (2001)

Apoptosis is a type of programmed cell death that is evident during embryonic development and normal tissue turnover. When the apoptotic activity extends beyond physiologic limits, it can determine and/or contribute to those pathologic states characterized by excessive cell loss and impairment of organ function. The clinical development of caspase inhibitors may represent a potential therapeutic strategy for influencing the onset and progression of ventricular dysfunction to terminal failure. This article focuses on the caspase cascade, a fundamental enzymatic system for apoptotic cell death. Caspases do not constitute the death signals, but are implicated in their transmission. These cytoplasmic cysteine proteases have a dual role in apoptosis. Caspases can operate as initiators, activating an endonuclease that catalyzes deoxyribonucleic acid fragmentation. Alternatively, caspases can act as effectors, participating in the total disassembly of cell structures. For example, apoptosis represents the principal form of myocyte death in the region of an acute myocardial infarction. In addition, apoptosis in the region bordering the infarct can influence the development of ischemic cardiomyopathy and ventricular dilation.
Hand-pumps as reservoirs for microbial contamination of well water (2011)

The retention and release of total coliforms and Escherichia coli was investigated in hand-pumps removed from tubewells tapping a faecally contaminated aquifer in Matlab, Bangladesh, and from a new hand-pump deliberately spiked with E. coli. All hand-pumps were connected to reservoirs of sterile water and flushed. Faecal coliforms were observed in the discharge from all three of the previously used hand-pumps, at concentrations comparable to levels measured in discharge when they were attached to the tubewells. During daily flushing of one of the previously used hand-pumps, the concentration of total coliforms in the discharge remained relatively constant (approximately 10³ MPN/100 mL). Concentrations of E. coli in the pump discharge declined over time, but E. coli was still detectable up to 29 days after the start of flushing. In the deliberately spiked hand-pump, E. coli was observed in the discharge over 125 days (t₅₀ = 8 days) and found to attach preferentially to elastomeric materials within the hand-pump. Attempts to disinfect both the village and new hand-pumps using shock chlorination were shown to be unsuccessful. These results demonstrate that hand-pumps can act as persistent reservoirs for microbial indicator bacteria. This could potentially influence drinking water quality and bias testing of water quality.
Skin Reactions in Patients With Multiple Sclerosis Receiving Cladribine Treatment (2021)

This study provides Class IV evidence that skin-related AEs are frequent in patients with MS following cladribine in a real-world setting.
THE 2MASS REDSHIFT SURVEY—DESCRIPTION AND DATA RELEASE (2012)

We present the results of the 2MASS Redshift Survey (2MRS), a ten-year project to map the full three-dimensional distribution of galaxies in the nearby universe. The Two Micron All Sky Survey (2MASS) was completed in 2003 and its final data products, including an extended source catalog (XSC), are available online. The 2MASS XSC contains nearly a million galaxies with K_s ≤ 13.5 mag and is essentially complete and mostly unaffected by interstellar extinction and stellar confusion down to a galactic latitude of |b| = 5° for bright galaxies. Near-infrared wavelengths are sensitive to the old stellar populations that dominate galaxy masses, making 2MASS an excellent starting point to study the distribution of matter in the nearby universe. We selected a sample of 44,599 2MASS galaxies with K_s ≤ 11.75 mag and |b| ≥ 5° (≥8° toward the Galactic bulge) as the input catalog for our survey. We obtained spectroscopic observations for 11,000 galaxies and used previously obtained velocities for the remainder of the sample to generate a redshift catalog that is 97.6% complete to well-defined limits and covers 91% of the sky. This provides an unprecedented census of galaxy (baryonic mass) concentrations within 300 Mpc. Earlier versions of our survey have been used in a number of publications that have studied the bulk motion of the Local Group, mapped the density and peculiar velocity fields out to 50 h^(–1) Mpc, detected galaxy groups, and estimated the values of several cosmological parameters. Additionally, we present morphological types for a nearly complete sub-sample of 20,860 galaxies with K_s ≤ 11.25 mag and |b| ≥ 10°.
Purification and characterization of a secretory lipolytic enzyme, MgLIP2, from Malassezia globosa (2011)

Malassezia globosa is a lipid-dependent yeast that is found on the human skin and is associated with various skin disorders, including dandruff and seborrhoeic dermatitis (SD). Despite its important role in skin diseases, the molecular basis for its pathogenicity is poorly understood. The current hypothesis is that dandruff and SD are linked to fatty acid metabolism and secretory lipolytic enzymes, which hydrolyse sebaceous lipids and release irritating free fatty acids. A previous genomic analysis of M. globosa identified a family of 13 homologous genes predicted to encode secreted lipases. We have also reported that M. globosa had significantly higher extracellular lipase activity compared with other species. To identify the major secretory lipases of this yeast during its growth, we successfully purified and characterized an extracellular lipase MgLIP2. Based on MALDI-TOF MS, the peptide mass fingerprint of a tryptically digested protein MgLIP2 corresponded to ORF MGL_4054 of M. globosa. This lipase showed high esterase activity against 4-nitrophenyl palmitate and 1-naphthyl palmitate but not 1-naphthyl acetate. This enzyme had optimal activity at 30 °C and pH 5.0. Furthermore, the activity significantly increased in the presence of Triton X-100 and was partially inhibited by PMSF but was unaffected by univalent and divalent metal ions.
N‐methyl‐d‐aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case‐control analyses (2003)

The N-methyl-d-aspartate glutamate receptors (NMDAR) act in the CNS as regulators of the release of neurotransmitters such as dopamine, noradrenaline, acetylcholine, and GABA. It has been suggested that a weakened glutamatergic tone increases the risk of sensory overload and of exaggerated responses in the monoaminergic system, which is consistent with the symptomatology of schizophrenia. We studied two silent polymorphisms in GRIN1. GRIN1/1 is a G/C substitution localized on the 5' untranslated region; GRIN1/10 is an A/G substitution localized in exon 6 of GRIN1. Minor allele frequencies in our sample were calculated to be 0.05 and 0.2 respectively. We genotyped 86 nuclear families and 91 ethnically matched case-control pairs. Both samples were collected from the Toronto area. We tested the hypothesis that GRIN1 polymorphisms were associated with schizophrenia using the transmission disequilibrium test (TDT) and comparing allele frequencies between cases and controls. The results are as follows: GRIN1/1: chi(2) = 2.19, P = 0.14; GRIN1/10: chi(2) = 1.5, P = 0.22. For the case-control sample: GRIN1/1: chi(2) = 0.013, P = 0.908; GRIN1/10: chi(2) = 0.544, P = 0.461. No significant results were obtained. Haplotype analyses showed a borderline significant result for the 2,1 haplotype (chi(2) = 3.86, P-value = 0.049). An analysis of variance (ANOVA) to evaluate the association between genetic makeup and age at onset was performed, with no significant results: GRIN1/1, F[df = 2] = 0.42, P-value = 0.659; GRIN1/10, F[df = 2] = 0.16, P-value = 0.853. We are currently collecting additional samples to increase the power of the analyses.
A Scalable Architecture For High-Throughput Regular-Expression Pattern Matching (2006)

We present and evaluate an architecture for highthroughput pattern matching of regular expressions. Our approach matches multiple patterns concurrently, responds rapidly to changes in the pattern set, and is well suited for synthesis in an ASIC or FPGA. Our approach is based on a new and easily pipelined state-machine representation that uses encoding and compression techniques to improve density. We have written a compiler that translates a set of regular expressions and optimizes their deployment in the structures used by our architecture. We analyze our approach in terms of its throughput, density, and efficiency. We present experimental results from an implementation in a commodity FPGA, showing better throughput and density than the best known approaches.
Calibrating two scientific echo sounders (2003)

The Simrad EK500 has been the state-of-the-art scientific echo sounder for surveying marine fish stocks; the EK60 is its successor. Both echo sounders have been calibrated with the same 38-kHz, 12-deg-beamwidth, split-beam transducer by the standard-target method at the acoustic calibration facility on Iselin Dock at the Woods Hole Oceanographic Institution. The principal measurements were on-axis target strengths and the two-way directivity patterns of the main lobe, measured with a 60-mm-diameter copper sphere. For each echo sounder, the respective split-beam-determined and directly measured angles of the standard target are compared. The directivity pattern as approximated by Simrad firmware is fit to the experimental data, and both the split-beam-determined and newly compensated values of target strength are expressed through histograms. Target strength distributions are compared for two spheres: a 60-mm-diameter aluminum and 38.1-mm-diameter tungsten carbide with 6% cobalt binder spheres.
Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19: Study Protocol for a Retrospective Observational Multicenter Study (SELECT) (Preprint) (2023)

<sec> <title>BACKGROUND</title> In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose corticosteroids are often administered as salvage late in the disease course, whereas earlier administration may be more beneficial in preventing disease progression. Previous research has revealed that increased levels of various biomarkers are associated with mortality, and whole blood transcriptome sequencing has the ability to identify host factors predisposing to critical illness in patients with COVID-19. </sec> <sec> <title>OBJECTIVE</title> Our goal is to determine the most optimal dosing and timing of corticosteroid therapy and to provide a basis for personalized corticosteroid treatment regimens to reduce morbidity and mortality in hospitalized patients with COVID-19. </sec> <sec> <title>METHODS</title> This is a retrospective, observational, multicenter study that includes adult patients who were hospitalized due to COVID-19 in the Netherlands. We will use the differences in therapeutic strategies between hospitals (per protocol high-dose corticosteroids or not) over time to determine whether high-dose corticosteroids have an effect on the following outcome measures: mechanical ventilation or high-flow nasal cannula therapy, in-hospital mortality, and 28-day survival. We will also explore biomarker profiles in serum and bronchoalveolar lavage fluid and use whole blood transcriptome analysis to determine factors that influence the relationship between high-dose corticosteroids and outcome. Existing databases that contain routinely collected electronic data during ward and intensive care admissions, as well as existing biobanks, will be used. We will apply longitudinal modeling appropriate for each data structure to answer the research questions at hand. </sec> <sec> <title>RESULTS</title> As of April 2023, data have been collected for a total of 1500 patients, with data collection anticipated to be completed by December 2023. We expect the first results to be available in early 2024. </sec> <sec> <title>CONCLUSIONS</title> This study protocol presents a strategy to investigate the effect of high-dose corticosteroids throughout the entire clinical course of hospitalized patients with COVID-19, from hospital admission to the ward or intensive care unit until hospital discharge. Moreover, our exploration of biomarker and gene expression profiles for targeted corticosteroid therapy represents a first step towards personalized COVID-19 corticosteroid treatment. </sec> <sec> <title>CLINICALTRIAL</title> ClinicalTrials.gov NCT05403359; https://clinicaltrials.gov/ct2/show/NCT05403359 </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/48183 </sec>
OpenSAN (2014)

In recent years, with the rapid development of satellite technology including On Board Processing (OBP) and Inter Satellite Link (ISL), satellite network devices such as space IP routers have been experimentally carried in space. However, there are many difficulties to build a future satellite network with current terrestrial Internet technologies due to the distinguished space features, such as the severely limited resources, remote hardware/software upgrade in space. In this paper, we propose OpenSAN, a novel architecture of software-defined satellite network. By decoupling the data plane and control plane, OpenSAN provides satellite network with high efficiency, fine-grained control, as well as flexibility to support future advanced network technology. Moreover, we also discuss some practical challenges in the deployment of OpenSAN.