gebhart/patrepeval huggingface dataset:
Phage P68 Virion-Associated Protein 17 Displays Activity against Clinical Isolates of Staphylococcus aureus (2005)

Phage-encoded murein hydrolases are either part of the lysis cassette or found as structural components of the phage virion. Here, we show that Staphylococcus aureus bacteriophage P68 contains a virion-associated muralytic enzyme. Protein 17 has a composite structure. The N-terminal part comprises the muralytic activity, whereas the C-terminal part is required for binding to the cell surface. A high multiplicity of infection with phage P68 caused rapid lysis, and purified protein 17 triggered premature lysis when added to S. aureus cells prior to infection with P68, suggesting that it functions to weaken the murein at the site of phage DNA entry. Protein 17 displayed activity against clinical S. aureus isolates, which are resistant to infection by phage P68, demonstrating that the protein targets surface structures distinct from the phage receptor. This broad activity spectrum of protein 17 could qualify virion-associated muralytic enzymes as attractive antimicrobials.
Deformable Image Registration: A Survey (2012)

Deformable image registration is a fundamental task in medical image processing. Among its most important applications, one may cite: i) multi-modality fusion, where information acquired by different imaging devices or protocols is fused to facilitate diagnosis and treatment planning; ii) longitudinal studies, where the development of phenomenon is studied over time; and iii) population modeling towards studying normal anatomical variability. In this research report, we attempt to give an overview of the deformable registration methods, putting emphasis on the most recent advances in the domain. Additional emphasis has been given to techniques applied to medical images. In order to study in depth image registration methods, their main components are identi ed and then studied independently. The most recent techniques are presented in a principled fashion.
Prediction of vinyl chloride monomer migration from rigid PVC pipe (1976)

Abstract Data on the solubility and diffusion of vinyl chloride monomer (VCM) in PVC resin powders have been combined with published solutions of Fick's diffusion equation to yield predictions of the amount and rate of loss of residual VCM (RVCM) from rigid PVC pipe under storage and service conditions. The principal factors controlling VCM migration are the initial VCM content, thickness of the PVC section, temperature and the age of the PVC product. Analysis Solutions are presented for RVCM loss from freshly exturded pipe (uniform VCM concentration) into either the storage environment or the pipe contents. From these solutions, estimates are made for the real‐world situation of closed‐system service following variable storage periods. The validity of this approach for rigid PVC pipe in water‐service is supported by reasonable agreement between its predictions and experimental laboratory data on the VCM content of water stored in PVC pipes. Both the predictive model and experimental data indicate that PVC pipe containing ≤ mg/kg (1 part per million) residual VCM will result in VCM concentrations in water of less than 0.002 mg/kg ‐ under any expected service conditions.
Improved 3D ray launching method forwireless propagation prediction (1997)

3D ray tracing produces accurate, deterministic channel models for wireless system design. Increasing a ray tracing algorithm&apos;s ability to identify correct propagation paths reduces the kinematic errors of a simulation. A new 3D ray tracing technique is presented that reduces kinematic errors associated with ray launching algorithms.
The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions (2020)

Crotoxin (CTX), the main neurotoxin from <i>Crotalus durissus terrificus</i> snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use. Under this scenario, the use of nanoparticle such as nanostructured mesoporous silica (SBA-15) as a carrier might become a feasible approach to improve CTX safety. Here, we determined the benefits of SBA-15 on CTX-related neuroinflammatory and immunomodulatory properties during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis that replicates several histopathological and immunological features observed in humans. We showed that a single administration of CTX:SBA-15 (54 μg/kg) was more effective in reducing pain and ameliorated the clinical score (motor impairment) in EAE animals compared to the CTX-treated EAE group; therefore, improving the disease outcome. Of interest, CTX:SBA-15, but not unconjugated CTX, prevented EAE-induced atrophy and loss of muscle function. Further supporting an immune mechanism, CTX:SBA-15 treatment reduced both recruitment and proliferation of peripheral Th17 cells as well as diminished IL-17 expression and glial cells activation in the spinal cord in EAE animals when compared with CTX-treated EAE group. Finally, CTX:SBA-15, but not unconjugated CTX, prevented the EAE-induced cell infiltration in the CNS. These results provide evidence that SBA-15 maximizes the immunomodulatory and anti-inflammatory effects of CTX in an EAE model; therefore, suggesting that SBA-15 has the potential to improve CTX effectiveness in the treatment of MS.
Systemic Carnitine Deficiency — A Treatable Inherited Lipid-Storage Disease Presenting as Reye's Syndrome (1980)

A 3 1/2-year-old boy presented at three months of age with an acute episode of lethargy, somnolence, hypoglycemia, hepatomegaly, and cardiomegaly, which responded poorly to restoration of the blood sugar level to normal. The absence of ketonuria during subsequent episodes of severe hypoglycemia prompted a search for a defect in fatty acid oxidation. Plasma carnitine (2.0 to 5.0 mumol per liter), muscle carnitine (0.01 to 0.02 mumol per gram, wet weight) and liver carnitine (0.021 to 0.065 mumol per gram, wet weight) were all less than 5 per cent of the normal mean. During a 36-hour fast, ketones were barely detectable. Prolonged treatment with oral carnitine over a six-month period resulted in increased muscle strength, a dramatic reduction in cardiac size, relief of cardiomyopathy, partial repletion of carnitine levels in plasma and muscle, and complete repletion in the liver. Systemic carnitine deficiency is an easily treatable cause of recurrent Reye's-like syndrome. Its diagnosis requires measurement of carnitine levels.
Hypocholesterolaemic effect of rat-administered oral doses of the isolated 7S globulins from cowpeas and adzuki beans (2015)

The role of seed proteins, especially soyabean 7S globulins, in controlling dyslipidaemia is widely acknowledged. Amino acid sequence homology among the proteins of this family could reflect similar biological functions in other species. The aim of the present study was to unveil a hypolipidaemic effect of the 7S globulins from cowpeas (7S-C) and adzuki beans (7S-A), administered orally to rats fed a hypercholesterolaemic (HC; high cholesterol and TAG) diet for 28 d. A total of forty-five rats were divided into five groups (nine rats per group): (1) standard (STD) diet; (2) HC diet; (3) HC diet + 7S-C (300 mg/kg per d); (4) HC diet + 7S-A (300 mg/kg per d); and (5) HC diet + simvastatin (SVT; 50 mg/kg per d), as a control. Significant decreases in food intake and final body weight of rats receiving HC + 7S-C and HC + 7S-A diets compared with groups fed the HC and STD diets were observed. Significant decreases in serum total and non-HDL-cholesterol of 7S-C, 7S-A and SVT groups were also observed. HDL-cholesterol levels increased in the 7S-C, 7S-A and SVT groups, while hepatic cholesterol and TAG concentrations were significantly lower than in the HC diet group for the 7S-C-supplemented group only. Faecal excretions of fat and cholesterol in HC diet groups were considerably higher in animals consuming the 7S globulins. The results show that cowpea and adzuki bean 7S globulins promote cholesterol-decreasing effects in hypercholesterolaemic rats even at low dosages, as already observed for other legume seed storage proteins of this family. This main effect is discussed in relation to the possible mechanisms of action.
Industrial Practices in Sustainability (2020)

This chapter deals with the evaluation of global efforts to achieve environmental sustainability. The aim is to assess the impact of industrialization and the efforts made by businesses, corporations, industrial units and governments to check environmental degradation. The strategies that have been adopted by industries to ensure sustainability and a balance between environment and economic growth are evaluated. The chapter examines a number of strategic initiatives being adopted by industries to achieve a balance between the environment, economic growth and society..
Artifacts induced by concomitant magnetic field in fast spin‐echo imaging (1998)

It has been observed that fast spin-echo (FSE) images with a large field of view (>40 cm) in certain directions exhibit unusual ghosting artifacts that cannot be eliminated with existing ghost removal methods. These artifacts have been related to a higher-order magnetic field perturbation (known as the concomitant field, or Maxwell field) concomitant to the linear imaging gradient, in accordance with the Maxwell equations V z B = 0 and V x B approximately 0. Several methods have been developed to eliminate or minimize the effects of the concomitant magnetic field by redesigning the FSE pulse sequences. In the slice-selection direction, the gradient waveforms are made symmetrical about the refocusing RF pulses wherever possible. Surrounding the first refocusing pulse, such symmetry cannot be achieved due to the slice-refocusing gradient, which is often combined with the left crusher. In this case, it is shown how crusher gradients can be reshaped to nullify the phase due to the concomitant field. In the phase-encoding direction, the gradient amplitude is reduced and its duration is prolonged. Artifacts due to the readout gradient are eliminated by reshaping the prephasing lobe, while keeping its area fixed. In all the three directions, the gradient waveforms are adjusted so that they have minimal overlap. Selected methods have been implemented on a clinical scanner, and typically reduce the ghost intensities in phantom and human images by a factor of 3.
X/X/Ka-band horn design (2002)

The NASA's Deep Space Network has a need for a multifrequency horn for simultaneous X/X/Ka-band operation in a beam waveguide antenna. The multifrequency horn will receive an X-band downlink (8.4-8.5 GHz) and a Ka-band downlink (31.8-32.3 GHz), and transmit an X-band uplink (7.145-7.235 GHz) signals simultaneously. The horn is designed for circularly polarized wave operation. Low loss (noise) and high power (up to 20 kilowatts) operation are considered in the horn design.
Normal metal - insulator - superconductor thermometers and coolers with titanium-gold bilayer as the normal metal (2018)

We have fabricated superconductor - insulator - normal metal - insulator - superconductor (SINIS) tunnel junctions in which Al acts as the superconductor, AlOx is the insulator, and the normal metal consists of a thin Ti layer (5 nm) covered with a thicker Au layer (40 nm). We have characterized the junctions by measuring their current-voltage curves between 60 mK and 750 mK. For comparison, the same measurements have been performed for a SINIS junction pair whose normal metal is Cu. The Ti-Au bilayer decreases the SINIS tunneling resistance by an order of magnitude compared to junctions where Cu is used as normal metal, made with the same oxidation parameters. The Ti-Au devices are much more robust against chemical attacks, and their lower tunneling resistance makes them more robust against static charge. More significantly, they exhibit significantly stronger electron cooling than Cu devices with identical fabrication steps, when biased close to the energy gap of the superconducting Al. By using a self-consistent thermal model, we can fit the current-voltage characteristics well, and show an electron cooling from 200 mK to 110 mK, with a non-optimized device.
Alexithymia as Predictor of Treatment Outcome in Patients with Functional Gastrointestinal Disorders (2003)

Alexithymia is a reliable and stable predictor of treatment outcome in FGID patients. Although further studies are needed, clinicians might improve treatment outcome by identifying patients with high alexithymia, and attempting to improve these patients' skills for coping with emotionally stressful situations.
Study of Forward Voltage Drift in Diffused SiC PiN Diodes Doped by Al or B (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Nondispersive hole transport in a spin-coated dendrimer film measured by the charge-generation-layer time-of-flight method (2002)

Measurements of the mobility of a first-generation (G1) bis-fluorene cored dendrimer have been performed on spin-coated samples of 500 nm thickness using the charge-generation-layer time-of-flight (TOF) technique. A 10 nm perylene charge generation layer was excited by the 532 nm line of a Q-switched Nd:YAG laser and the generated carriers swept through the dendrimer film under an applied field. We observe nondispersive hole transport in the dendrimer layer with a room-temperature mobility μ=2.0×10−4 cm2/V s at a field of 0.55 MV/cm. There is a weak field dependence of the mobility and it increases from μ=1.6×10−4 cm2/V s at 0.2 MV/cm to μ=3.0×10−4 cm2/V s at 1.4 MV/cm. These results suggest that the measurement of mobility by TOF in spin-coated samples on thickness scales relevant to organic light-emitting diodes can yield valuable information, and that dendrimers are promising materials for device applications.
The morphology and deformation behavior of poly(butylene terephthalate) blends (1987)

Impact-modified blends of BPA polycarbonate (BPAPC) and poly(butylene terephthalate) (PBT) are being used to an increasing extent in engineering applications requiring superior low temperature toughness (e.g., automotive bumpers). In order to optimize the performance of these materials in such demanding situations, it is essential to develop a thorough understanding of the factors affecting their microstructure and deformation behavior. To be successful in this endeavor, an interdisciplinary effort involving detailed microscopic characterization, sophisticated mechanical testing, and careful analytical studies is required. Although some work of this type has appeared in the literature (1,2) together with more fundamental research on BPAPC/PBT miscibility (3-6), major questions with respect to phase segregation, distribution of blend components, and morphological changes which occur during deformation remain. In response to these issues, a more complete investigation of the microstructure and deformation characteristics of several PBT blends containing various combinations of polycarbonate and impact modifier was recently carried out in our laboratory.
VTOL UAV - A Concept Study (2008)

This thesis deals with the development of a Conceptual Design Tool for unmanned helicopters, so called VTOL UAVs. The goal of the Design Tool is: • Quick results • Good accuracy • Easy to use The two first points of the goal are actually more or less dependent on each other. In almost all cases a high accuracy gives a slow calculator and vice versa. In order to fulfill the goal a compromise between calculation accuracy and calculation time needs to be done. To make the Design Tool an easy to use program a graphical user interface is used. The graphical user interface allows the user to systematically work his way thru the program from a fictive mission to a complete design of a helicopter. The pre-requirements on the user have been eliminated to a minimum, but for the advanced user the possibilities to create more specific and complex helicopters are good. In order to develop a Conceptual Design Tool the entire helicopter needs to be seen as a complete system. To see the helicopter as a system all of the sub parts of a helicopter need to be studied. The sub parts will be compared against each other and some will be higher prioritized than other. The outline of this thesis is that it is possible to make a user friendly Conceptual Design Tool for VTOL UAVs. The design procedure in the Design Tool is relatively simple and the time from start to a complete concept is relatively short. It will also be shown that the calculation results have a good agreement with real world flight test data.
High Bandwidth Non-Resonant High Voltage Generator for X-Ray Systems (2018)

High-voltage supplies for medical X-ray systems require up to 150 kV DC at up to 100 kW to supply the tube. The challenge for the power supply however is not only to deal with the high voltage and high power demand, but also to provide short voltage rise- and fall times in the range of 100μs. A coupled interleaved circuit variant of a single active bridge concept, the coupled interleaved single active bridge converter, is demonstrated in this work providing very fast output voltage control due to its non-resonant structure. The conduction modes of the circuit are analysed in detail and compared to the uncoupled interleaved single active bridge approach, demonstrating the advantages of low inverter RMS current, zero voltage switching (or at least zero current switching) over the full operating range with constant switching frequency. Analytic expressions for the output current-duty cycle relationship are provided. Experiments on a 60 kW (low voltage equivalent) prototype show that rise times as low as five switching cycles are possible, allowing to reach the target of 100μs rise time using a switching frequency of only 50 kHz.
Real-World Data from the MiniMed™ 670G System Commercial Launch—Patients Previously Using MDI Therapy (2018)

The Medtronic MiniMed™ 670G hybrid closed-loop system with SmartGuard™ technology was released for commercial use in the U.S. in March 2017. Data from patients previously managing their diabetes with multiple daily insulin injections (MDI) therapy who transitioned to the MiniMed™ 670G system are reported. MiniMed™ 670G system data from patients who voluntarily uploaded to CareLink™ Personal software, from 3/17/17 to 12/14/17 (n=158), were de-identified and analyzed if there were ≥7 days of sensor wear. Comparisons were made of glycemic metrics between 4,529 patient-days in the initial open-loop Manual Mode and 14,1patient-days after initiating closed-loop Auto Mode features. The Table shows glycemic metrics during Manual Mode and after Auto Mode start and that time spent in target range increased, while time spent in low and high glucose levels decreased. Real-world findings from patients previously using MDI who transitioned to the MiniMed™ 670G system demonstrated increased TIR and reduced time in hypoglycemia and hyperglycemia, consistent with pivotal trial1 results in patients previously using pump therapy +/- CGM. Prior MDI patients also showed greater TIR the more time spent in Auto Mode. Disclosure S. Gopalakrishnan: Employee; Self; Medtronic. P. Agrawal: None. M. Stone: None. C. Fogel: Employee; Self; Medtronic. S.W. Lee: Employee; Self; Medtronic.
Bandwidth variability prediction with rolling interval least squares (RILS) (2012)

Real Time prediction of end-to-end bandwidth is crucial for network quality of service. It remains a challenge for providing prediction in good quality. This is mainly because of uncertainties involved in network communication. Very recently a new algorithm called Rolling Interval Least Squares (RILS) [3] has been developed which significantly improved the variability forecast of the stock market. In this paper we extend the interval computing approach and applied RILS to innovatively predict bandwidth based on a wide range of rates. Experimental results indicate that RILS improved the quality of bandwidth variability prediction by about 24% when compared to current methods.
Ex-vivo-Expansion perikardialer Patchstrukturen : zur Frage des Einflusses von zyklischem Stress und laminaren Strömungsbedingungen auf das Ex-vivo-Remodelling perikardialer Patchstrukturen (2009)

BACKGROUND: Pericardium is widely used as a patch structure in paediatric cardiovascular heart surgery. However, the major problem still is the restricted availability and level of quality of autologous pericardium. Based on those limiting factors, a new concept has already been tested in a pilot study combining the mesh graft technique of burn surgery with the principles of tissue engineering to expand pericardial tissue ex vivo. The aims of this dissertation were to verify the preliminary result and improve the culture conditions and systems to optimize the synthesis of pericardial neo-tissue. In addition, the characteristics of native and pre-isolated pericardial cells concerning active migration and proliferation in fibrin gel scaffolds should be investigated. METHODS: Perforated porcine pericardial patches filled up with a fibrin-cell-carrier were cultivated in custom-designed bioreactor systems up to 20 days, one group under cyclic stress conditions observing the influences of different frequencies (f equal to or less than 10/min) on tissue-engineered samples and the other under laminar shear stress conditions using cell-seeded and cell-free fibrin gel scaffolds to compare levels of cell migration and proliferation. Extracellular matrix- (ECM) composition was analysed in all samples using routine histological and immunohistochemical techniques. RESULTS: Under stimuli of cyclic stress the neo-tissue synthesis has shown cell necrosis and scaffold dissections while under laminar flow conditions a positive development of ECM-deposition and matrix-remodelling could be observed. Moreover, active migration of pericardial cells into fibrin gel matrices from native tissue could be shown for the first time. The high number of migrated pericardial cells caused an extensive remodelling of fibrin gel matrix by typical ECM-proteins like type I and type III collagen as same as elastin. But in 20 days of cultivation the fibrin gel scaffold has not been entirely replaced by neo-tissue in any perforated patch. CONCLUSIONS: Native pericardial cells represent a promising resource to generate patch structures for pediatric cardiovascular heart surgery. In addition, this concept of ex vivo expansion can be realized without any cell culture. Nevertheless, further investigations have to verify the present results. Optimized culture parameters may increase the mechanical and functional characteristics of expanded pericardial tissue to the point of total replacement of scaffold while prospective animal studies will clarify the possible clinical benefit.