gebhart/patrepeval huggingface dataset:
Deep Rest: An Integrative Model of How Contemplative Practices Combat Stress and Enhance the Body’s Restorative Capacity (2022)

Engaging in contemplative practices like meditation, yoga, and prayer, is greatly beneficial for psychological and physical well-being. Recent research has identified some of the underlying psychological and biological pathways that explain these benefits. However, an overarching model has yet to be developed that incorporates the latest research from intervention and experimental studies with the physiological processes related to contemplative practices. In this paper, we link divergent scientific literature on contemplative practice interventions, stress science, and mitochondrial biology, presenting a unified and biologically focused model of how contemplative practices promote physical health. We argue that engaging in contemplative practice facilitates a restorative state termed ‘deep rest,’ largely facilitated by safety signaling, during which energetic resources move towards cellular optimization and away from an energy-demanding threat-arousal state. In sum, our model presents a framework for how contemplative practices enhance positive psychological and physical functioning by improving how cellular energy is consumed.
Bacillus pocheonensis sp. nov., a moderately halotolerant, aerobic bacterium isolated from soil of a ginseng field (2007)

A Gram-positive, non-motile, endospore-forming bacterial strain, designated Gsoil 420T, was isolated from soil of a ginseng field in Pocheon Province, South Korea, and was characterized, using a polyphasic approach, in order to determine its taxonomic position. The novel isolate consisted of strictly aerobic, rod-shaped cells and was able to grow in medium supplemented with up to 12% NaCl at 25 degrees C and pH 6.5-7.0. Comparative 16S rRNA gene sequence analysis showed that strain Gsoil 420T fell within the radiation of the cluster comprising Bacillus species and formed a coherent cluster with Bacillus niacini (16S rRNA gene sequence similarity, 98.6%), Bacillus bataviensis (98.6%), Bacillus soli (98.3%), Bacillus drentensis (98.0%), Bacillus novalis (98.0%), Bacillus vireti (97.9%), Bacillus foraminis (97.6%), Bacillus fumarioli (97.4%) and Bacillus jeotgali (97.0%). The levels of 16S rRNA gene sequence similarity with respect to other Bacillus species with validly published names were less than 96.8%. Strain Gsoil 420T had a genomic DNA G+C content of 44.9 mol% and the predominant respiratory quinone was MK-7. The major fatty acids were anteiso-C15:0 (33.9%), iso-C15:0 (24.5%) and iso-C14:0 (19.9%). These chemotaxonomic results supported the affiliation of strain Gsoil 420T to the genus Bacillus. However, low DNA-DNA relatedness values and distinguishing phenotypic characteristics allowed genotypic and phenotypic differentiation of strain Gsoil 420T from recognized Bacillus species. On the basis of its phenotypic properties and phylogenetic distinctiveness, strain Gsoil 420T represents a novel species of the genus Bacillus, for which the name Bacillus pocheonensis sp. nov. is proposed. The type strain is Gsoil 420T (=KCTC 13943T=DSM 18135T).
Nanometer-scale observation of ferroelectric domains using an apertureless near-field optical microscope (2000)

Optical observation of the polarization domain structure of a ferroelectric material (triglycine sulfate) is achieved using a reflection apertureless near-field optical microscope operating with an electrical ac polarization of the tip. By showing that there is no detectable contribution of the converse piezoelectric effect of the sample nor of the electrical forces acting on the tip in the optical signal detected, we explain the observed contrast between domains of opposite polarity by the electro-optic effect. Using the phase of the demodulated optical signal, we image the ferroelectric domain structure with a resolution better than 35 nm.
Microbial iron transport via a siderophore shuttle: A membrane ion transport paradigm (2000)

A mechanism of ion transport across membranes is reported. Microbial transport of Fe(3+) generally delivers iron, a growth-limiting nutrient, to cells via highly specific siderophore-mediated transport systems. In contrast, iron transport in the fresh water bacterium Aeromonas hydrophila is found to occur by means of an indiscriminant siderophore transport system composed of a single multifunctional receptor. It is shown that (i) the siderophore and Fe(3+) enter the bacterium together, (ii) a ligand exchange step occurs in the course of the transport, and (iii) a redox process is not involved in iron exchange. To the best of our knowledge, there have been no other reports of a ligand exchange mechanism in bacterial iron transport. The ligand exchange step occurs at the cell surface and involves the exchange of iron from a ferric siderophore to an iron-free siderophore already bound to the receptor. This ligand exchange mechanism is also found in Escherichia coli and seems likely to be widely distributed among microorganisms.
Central Neurogenic Antiinflammatory Action of α-MSH: Modulation of Peripheral Inflammation Induced by Cytokines and Other Mediators of Inflammation (1994)

The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) has potent antipyretic and antiinflammatory properties. When administered systemically, the naturally occurring molecule and its COOH-terminal tripeptide sequence inhibit inflammation induced by peripherally applied irritants and intradermal injections of mediators of inflammation such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF alpha). We recently found that alpha-MSH can act solely within the brain to inhibit inflammation caused by a general irritant applied to the skin. This activity appears to be shared with salicylate drugs and the combined observations suggest the existence of descending neurogenic antiinflammatory signals capable of modulating inflammation in peripheral tissues. To improve our knowledge of the scope of this action of the peptide, alpha-MSH was injected into the cerebral ventricles (i.c.v.) of mice that had received intradermal injections in the ear of mediators of inflammation: IL-1 beta, IL-8, leukotriene B4, and platelet-activating factor. The centrally administered peptide inhibited the actions of all of these proinflammatory agents as determined from comparisons with measures of ear edema over time in control animals; this indicates that the central peptide can alter inflammation induced in the periphery by major mediators of inflammation. In tests confined to IL-1 beta, central administration of alpha-MSH(11-13) was also effective. These findings support the concept of a descending neurogenic antiinflammatory influence promoted by an action of alpha-MSH within the brain, an inhibitory influence that is not restricted to modulation of just one or a limited set of the mediators of inflammation.
Directly Probing the Racemization of Imidazolines by Vibrational Circular Dichroism: Kinetics and Mechanism (2010)

The first report of monitoring the kinetics of racemization in solution by online vibrational circular dichroism (VCD), chemometrics, and density functional theory (DFT) calculations is presented. The activation energy for the racemization of an imidazoline based on the experimental VCD was determined, and the detailed mechanism of the process utilizing DFT calculations was elucidated. This study demonstrates the utility of VCD for the determination of reaction mechanisms in asymmetric transformations.
A fleet of multiparameter observatories for geophysical and environmental monitoring at seafloor (2006)

Seafloor long-term, multiparameter, single-frame observatories have been developed within the framework of European Commission and Italian projects since 1995. A fleet of five seafloor observatories, built-up starting from 1995 within the framework of an effective synergy among research institutes and industries, have carried out a series of long-term sea experiments. The observatories are able to operate from shallow waters to deep sea, down to 4,000 m w.d., and to simultaneously monitor a broad spectrum of geophysical and environmental processes, including seismicity, geomagnetic field variations, water temperature, pressure, salinity, chemistry, currents, and gas occurrence. Moreover, they can transmit data in (near)-real-time that can be integrated with those of the on-land networks. The architecture of the seafloor observatories follows the criteria of modularity, interoperability and standardisation in terms of materials, components and communication protocols. This paper describes the technical features of the observatories, their experiments and data.
Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO). 3. Effect of Mildly Acidic pH on the Thermodynamics and Kinetics of Adduct Formation (2008)

The nitrone, 5,5-dimethylpyrroline N-oxide (DMPO), is a commonly used spin trap for the detection of superoxide radical anion (O2*-) using electron paramagnetic resonance spectroscopy. This work investigates the reactivity of DMPO to O2*- in mildly acidic pH (5.0-7.0). Mild acidity is characteristic of acidosis and has been observed in hypoxic systems, e.g., ischemic organs and cancer cells. Although the established pKa for O2*- is 4.8, the pKa for DMPO is unknown. The pKa of the conjugate acid of DMPO was determined to be 6.0 using potentiometric, spectrophotometric, 1H and 13C NMR, and computational methods. 1H and 13C NMR were employed to investigate the site of protonation. An alternative mechanism for the spin trapping of O2*- in mildly acidic pH was proposed, which involves protonation of the oxygen to form the N-hydroxy imino cation and subsequent addition of O2*-. The exoergicity of O2*- addition to protonated DMPO was rationalized using density functional theory (DFT) at the PCM/B3LYP/6-31+G**//B3LYP/6-31G* level of theory.
Isolation and characterization of membrane-bound L-sorbose dehydrogenase from Gluconobacter melanogenus UV10. (1991)

Membrane-bound L-sorbose dehydrogenase was purified from the membrane fraction of Gluconobacter melanogenus UV10. The reaction with 2, 6-dichlorophenolindophenol or phenazine methosulfate as acceptor was formulated as; L-sorbose + acceptor →-sorbosone + reduced acceptor. The enzyme was purified by DEAE-Cellulose, DEAE-Sepharose, and Sephadex G-200 column chromatographies after differential solubilization with Triton X-100 and Tween 80, and appeared as a single band in a SDS-PAGE gel at the molecular weight of about 58, 000. It was most active at pH 7.0 and 48°C, and rather stable at around 7.0 in a buffer containing 200 mM L-sorbose, below 30°C. It showed high substrate specificity for L-sorbose, and its activity was stimulated by Fe3+ and Co2+, and inhibited by Cu2+, quinine, mono-iodoacetate, and sodium fluoroacetate.
Dressing spray enhances the adhesive strength of surgical dressing tapes (2006)

The results indicated that dressing spray tested has an additional adhesive power besides its well known features and that it can be used as an efficient alternative material among other adhesive compounds.
Intracytoplasmic sperm injection: current status of the technique and outcome (2007)

Since the birth of Louise Brown in 19781, in vitro fertilization (IVF) has proved to be an efficient treatment to alleviate female factor infertility (tubal infertility and endometriosis) and unexplained infertility. When IVF was applied in couples with male infertility, it became apparent for all groups that the results were much less efficient. The normal fertilization rate of inseminated oocytes was significantly lower, resulting in the formation of many fewer embryos, which meant that embryos were not available for transfer in a substantial number of cycles2.
7.1.4 Monitoring breath carbon monoxide gas using micro thermoelectric sensor (2012)

The CO gas, which is several ppm level in the human breath, is used for medical examination. In this study, CO combustion catalysts of Au, Pt and Pd loaded on CoO on the thermoelectric gas sensor (TGS) were developed and the combustion performance of these catalysts was evaluated. We have demonstrated that the micro-THS detected the CO concentration in air from low as 1 ppm to high as 1 vol%. The noise voltage level of the sensor was 0.13V, and the signal to noise ratio, S/N was 2.09V/0.13V = 16.1 for 1ppm CO/air.
The effect of non‐ionic detergent tween 80 on colcemid‐resistant transformed mouse cells in vitro (1975)

The effect of the non-ionic detergent tween 80 on one colcemid-resistant and one sensitive subline of mouse L cells has been studied. The colcemid-resistant subline was also resistant to colchicine and Vinca alkaloids. Tween 80 at concentrations of 0.01% (v/v) or higher increased the sensitivity of drug-resistant cells to the antimitotic effect of colcemid, colchicine and vinblastine. Tween 80 also potentiated the initial rate and the maximal level of the (3-H)-cholchicine uptake by both sensitive and resistant cells. However, the detergent at concentrations of up to 1% had no effect on (3-H)-colchicine binding by cell homogenates. Thus it appears that the effects of tween 80 were due to an increase in cell membrane permeability to the drugs. The effect was completely reversible. The cells did not become adapted to the sensitizing action of tween 80 even after prolonged incubation in medium containing the detergent. A considerable increase in the permeability to the drug was obtained with doses of tween 80 which were non-toxic and which had no effect on cell proliferation, morphology and locomotion. The increase in membrane permeability caused by tween 80 at these concentrations was selective, the membrane permeability to ions and to (3-H)-2-deowy-D-glucose being, in fact, unchanged.
Insights from the sharp end of intravenous medication errors: implications for infusion pump technology (2005)

Medication errors associated with IV pumps occur frequently, have the potential to cause harm, and are epidemiologically diverse. Smart pumps are a necessary component of a comprehensive safe medication system. However, currently available smart pumps will fail to generate meaningful improvements in patient safety until they can be interfaced with other systems such as the electronic medical record, computerized prescriber order entry, bar coded medication administration systems, and pharmacy information systems. Future research should focus on the effectiveness of new technology in preventing latent and active errors, and on new types of error that any technology can introduce.
Range correlation effects on phase and amplitude noise (2002)

The authors address the problem of characterizing the effects of range correlation and local oscillator amplitude and phase noise on the intermediate-frequency (IF) spectrum of a coherent, continuous wave or pulsed Doppler radar. Since the amplitude and phase noises are stochastic processes, the problem is defined in a stochastic processes context, and a reasonable set of assumptions is imposed to produce a general, straightforward, and easily understood solution. The solution clearly indicates how the natural spectrum of the scatterer, the amplitude and phase noise spectra, and range correlation combine to produce the IF spectrum. A specific example is provided for the case of a pulsed Doppler radar. The results presented indicate that range correlation can have a significant impact on the IF spectrum and thus should be considered in radar analysis and design activities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice (2022)

Hemophilia A is an inherited bleeding disorder caused by defective or deficient coagulation factor VIII (FVIII) activity. Until recently, the only treatment for prevention of bleeding involved IV administration of FVIII. Gene therapy with adeno-associated vectors (AAVs) has shown some efficacy in patients with hemophilia A. However, limitations persist due to AAV-induced cellular stress, immunogenicity, and reduced durability of gene expression. Herein, we examined the efficacy of liver-directed gene transfer in FVIII knock-out mice by AAV8-GFP. Surprisingly, compared with control mice, FVIII knockout (F8TKO) mice showed significant delay in AAV8-GFP transfer in the liver. We found that the delay in liver-directed gene transfer in F8TKO mice was associated with absence of liver sinusoidal endothelial cell (LSEC) fenestration, which led to aberrant expression of several sinusoidal endothelial proteins, causing increased capillarization and decreased permeability of LSECs. This is the first study to link impaired liver-directed gene transfer to liver-endothelium maladaptive structural changes associated with FVIII deficiency in mice.
One-Pot Synthesis of Hyperbranched Polyethoxysiloxanes (2006)

Hyperbranched polyethoxysiloxanes were prepared via a one-pot synthetic route based on a condensation reaction of tetraethoxysilane with acetic anhydride in the presence of an organotitanium catalyst. Volatile compounds can be fully removed using a thin-film evaporator. According to size-exclusion chromatography and viscosity measurements, the average molecular weight as well as the molecular weight distribution of the products increased exponentially by increasing the molar ratio of acetic anhydride to tetraethoxysilane from 1.0 to 1.2. At the molar ratio 1.3, a solid gel was formed. The liquid products are stable and hydrophobic; they are miscible with most organic solvents. 29Si NMR spectroscopy and MALDI-ToF mass spectrometry show that they have a hyperbranched structure with additional internal loop formation.
Energy dependence of energy transfer in the collisional relaxation of vibrationally highly excited carbon disulfide (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnergy dependence of energy transfer in the collisional relaxation of vibrationally highly excited carbon disulfideGyorgy Lendvay and George C. SchatzCite this: J. Phys. Chem. 1991, 95, 22, 8748–8753Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/j100175a061https://doi.org/10.1021/j100175a061research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Fermentative Approaches to Hydrogen Production (Presentation) (2005)

A PowerPoint presentation given as part of the 2005 Hydrogen Program Review, May 23-26, 2005, in Washington, D.C.
Branching Songs (2022)

In cities, trees are seen predominantly as entities that beautify streets, parks and gardens. Often they’re regarded as obstacles to urban development, where their importance to ecosystem health plays a secondary role to economic growth. How can multispecies art offer new perspectives on trees and their crucial contributions to urban life? Branching Songs is a project with old trees in the Vancouver area, including the ‘1308 Trees’, urban forest sites where trees are being cleared for the Transmountain Pipeline expansion. The intention is to bear witness to trees who are supporting the well-being of human and nonhuman life. The project combines new technologies, such as 360° photography and video, ambisonic and geophonic sound recording, biomidi data, and contact mic recording, with approaches from acoustic ecology, multispecies creativity, and performance. The Branching Songs team produced methods for working collaboratively with trees and composed a collection of soundscapes and accompanying 360° photos and videos. The soundscapes present the complex biophony and anthropophony of each site, weaving in soundings from electromagnetic fields produced by the trees and our touch interactions with the tree bodies. The touch gestures are improvisational, responding to the emergent sounds heard on site, and the specific features of the participating tree. Multiple microphones allow us to listen to varied perspectives refracted across the tree body. Our video article includes an introduction to the project, the methods we developed, two soundscape compositions and accompanying visuals with the trees in the collaboration.@font-face{font-family:"Cambria Math";panose-1:2 4 5 3 5 4 6 3 2 4;mso-font-charset:0;mso-generic-font-family:roman;mso-font-pitch:variable;mso-font-signature:-536870145 1107305727 0 0 415 0;}@font-face{font-family:"Helvetica Neue";panose-1:2 0 5 3 0 0 0 2 0 4;mso-font-charset:0;mso-generic-font-family:auto;mso-font-pitch:variable;mso-font-signature:-452984065 1342208475 16 0 1 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal{mso-style-unhide:no;mso-style-qformat:yes;mso-style-parent:"";margin:0in;mso-pagination:widow-orphan;font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman";}.MsoChpDefault{mso-style-type:export-only;mso-default-props:yes;font-family:"Calibri",sans-serif;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;}div.WordSection1{page:WordSection1;}