gebhart/patrepeval huggingface dataset:
A New Family of Insulin‐Mimetic Vanadium Complexes Derived from 5‐Carboalkoxypicolinates (2003)

The reaction of 5-carboalkoxypicolinic acid (5 ROpicH, R=Me, Et, iPr, sBu; 1 a-d) with vanadyl sulfate yielded the complexes [VO(H(2)O)(5 ROpic)(2)], 2 a-d, with H(2)O and one of the picolinato ligands in the equatorial positions, and the second picolinate occupying equatorial (N) and axial (O) positions. Reaction of 1 a with [NH(4)][VO(3)] yielded [NH(4)][VO(2)(5 MeOpic)(2)], [NH(4)]-3, in which the N functions of the picolinates are trans to the doubly bonded, cis-positioned oxo groups. Complexes 1 a.H(2)O, 1 b, 1 c, 2 a.3.5 H(2)O and [NH(4)]-3.4 H(2)O have been structurally characterised. A detailed pH-potentiometric solution speciation analysis of the system VO(2+)-1 a revealed a dominance of VO(5 OMepic)(2) between pH 2 and 6, with the same coordination pattern, evidenced by EPR spectroscopy, as in the crystalline solid state. In ternary systems containing physiological concentrations of the low molecular mass biogenic binders (B) lactate, oxalate, citrate or phosphate, ternary species of general composition VO(5 MeOpic)B dominate at physiological pH, with citrate being the most effective competitor for picolinate. All of the complexes trigger glucose uptake and degradation by simian virus modified mice fibroblasts at non-toxic concentrations (<100 microM), with 2 a, [VO(2)(pic)(2)](-) and [VO(2)(dipic)](-) being at least as effective as insulin. Vanadium uptake by the cells is most effective in the case of 2 a. 2 a also effectively inhibits free fatty acid release by rat adipocytes treated with epinephrine, thus mimicking the inhibition of lipolysis by insulin.
Cytotoxic T lymphocytes form an antigen-independent ring junction (2004)

Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cell receptor cluster, the central supramolecular activation cluster (cSMAC). In CD8(+) cytotoxic T lymphocytes, the immunological synapse is thought to facilitate specific killing by confining cytotoxic agents to the synaptic cleft. We have investigated the interaction of human CTLs and helper T cells with supported planar bilayers containing ICAM-1. This artificial substrate provides identical ligands to CD4(+) and CD8(+) T cells, allowing a quantitative comparison. We found that cytotoxic T lymphocytes form a ring junction similar to a pSMAC in response to high surface densities of ICAM-1 in the planar bilayer. MICA, a ligand for NKG2D, facilitated the ring junction formation at lower surface densities of ICAM-1. ICAM-1 and MICA are upregulated in tissues by inflammation- and stress-associated signaling, respectively. Activated CD8(+) T cells formed fivefold more ring junctions than did activated CD4(+) T cells. The ring junction contained lymphocyte function associated antigen-1 and talin, but did not trigger polarization and granule translocation to the interface. This result has specific implications for the mechanism of effective CTL hunting for antigen in tissues. Abnormalities in this process may alter CTL reactivity.
Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles (2017)

Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles. The wrinkle on each side of the subject's face was randomly assigned to a HA microneedle patch or HA essence application twice a week for 8 weeks. Efficacy was evaluated at weeks 2, 4, and 8. Skin wrinkles were measured as average roughness using replica and PRIMOS. Skin elasticity was assessed using a cutometer. Two independent blinded dermatologists evaluated the changes after treatment using the global visual wrinkle assessment score. Subjects assessed wrinkles using the subject global assessment score. Skin wrinkles were significantly reduced and skin elasticity significantly increased in both groups, although improvement was greater in the patch group at week 8 after treatment. In the primary and cumulative skin irritation tests, the HA microneedle patch did not induce any skin irritation. The HA microneedle patch is more effective than the HA essence for wrinkle improvement and is a safe and convenient without skin irritation.
The van der Waals Interactions of n‐Alkanethiol‐Covered Surfaces: From Planar to Curved Surfaces (2017)

Abstract The van der Waals (vdW) interactions of n ‐alkanethiols (ATs) adsorbed on planar Au(111) and Au(100) surfaces and curved Au nanoparticles of different diameters are reported. By means of electrochemical measurements and molecular dynamic calculations, the increase in the average geometrical curvature of the surface influences the global interactions, that is, decreasing vdW interactions between neighboring molecules. Small NPs do not present the same electrochemical behavior as planar surfaces. The transition between nanoparticle to flat surface electrochemical response is estimated to occur at a circa 13–20 nm diameter range.
Valproic Acid Protects Motor Neuron Death by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Cytochrome C Release after Spinal Cord Injury (2013)

Both oxidative stress and endoplasmic reticulum (ER) stress are known to contribute to secondary injury, ultimately leading to cell death after spinal cord injury (SCI). Here, we showed that valproic acid (VPA) reduced cell death of motor neurons by inhibiting cytochrome c release mediated by oxidative stress and ER stress after SCI. After SCI, rats were immediately injected with VPA (300 mg/kg) subcutaneously and further injected every 12 h for an indicated time period. Motor neuron cell death at an early time after SCI was significantly attenuated by VPA treatment. Superoxide anion (O2-) production and inducible NO synthase (iNOS) expression linked to oxidative stress was increased after injury, which was inhibited by VPA. In addition, VPA inhibited c-Jun N-terminal kinase (JNK) activation, which was activated and peaked at an early time after SCI. Furthermore, JNK activation and c-Jun phosphorylation were inhibited by a broad-spectrum reactive oxygen species (ROS) scavenger, Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), indicating that ROS including O2- increased after SCI probably contribute to JNK activation. VPA also inhibited cytochrome c release and caspase-9 activation, which was significantly inhibited by SP600125, a JNK inhibitor. The levels of phosphorylated Bim and Mcl-1, which are known as downstream targets of JNK, were significantly reduced by SP600125. On the other hand, VPA treatment inhibited ER stress-induced caspase-12 activation, which is activated in motor neurons after SCI. In addition, VPA increased the Bcl-2/Bax ratio and inhibited CHOP expression. Taken together, our results suggest that cell death of motor neurons after SCI is mediated through oxidative stress and ER stress-mediated cytochrome c release and VPA-inhibited cytochrome c release by attenuating ROS-induced JNK activation followed by Mcl-1 and Bim phosphorylation and ER stress-coupled CHOP expression.
Gold-Catalyzed Intramolecular Aminoarylation to Pyrrolidines (2010)

Based on previous work on gold-catalyzed hydroamination reactions by the same group (Angew. Chem. Int. Ed. 2010, 49, 598), the corresponding gold-catalyzed intramolecular aminoarylation reaction of N-sulfonylalkenes with boronic acids has been shown to lead to N-protected pyrrolidines and piperidines. [dppm(AuBr)2] in combination with Selectfluor® as an oxidative agent was found to catalyze the formation of pyrrolidines at room temperature in good yields while the formation of piperidines required heating at 40-60 ˚C. The reaction is proposed to proceed via a redox cycle involving the initial oxidation of gold(I) into gold(III) by Selectfluor®. Based on studies of competitive reactions using Ph-AuPPh3 and ArB(OH)2 the incorporation of the Ar moiety was demonstrated, thus suggesting that the C-C bond formation does not proceed through a reductive elimination from a phenylgold(III) species but through a bimolecular reductive elimination process.
Desarrollo de una plataforma eficiente de análisis de datos en bioinformática y biología computacional (2010)

La difusion de tecnicas experimentales a gran escala en el area biomedica ha permitido el estudio de la Biologia Molecular desde una perspectiva global, pero tambien ha generado una enorme cantidad de informacion que es necesario procesar y analizar para extraer conocimiento biologico, ya sea con el fin de plantear nuevas hipotesis de trabajo o para confirmar las hipotesis previamente consideradas. 
En esta tesis doctoral se ha desarrollado una plataforma de analisis funcional orientada al analisis de datos de expresion genica y a su integracion con informacion biologica externa de diversa naturaleza. En concreto, se partio del desarrollo de una novedosa metodologia de extraccion de patrones frecuentes a partir de grandes conjuntos de datos que sirvio para la creacion de una aplicacion basada en enriquecimiento modular de anotaciones biologicas para caracterizar listas de genes y la elaboracion de una metodologia de extraccion de reglas asociativas a partir de datos de expresion genica. Sin embargo, los metodos de analisis funcional actuales se encuentran limitados por la gran redundancia inherente a la informacion biologica y por el sesgo en la distribucion de esta informacion. En esta tesis se estudia este problema y se propone un novedoso y robusto metodo de recuperacion de modulos de genes y topicos biologicos que soluciona el problema de la redundancia en datos, explicando de manera veraz y resumida la biologia asociada a un conjunto de genes. 
Adicionalmente, el afan puesto en el estudio e integracion de datos desemboco en la recopilacion de un conjunto genes y proteinas considerados centrosomales en base a una serie de evidencias y a la consecuente creacion de una base de datos orientada al estudio de dicho complejo celular desde diversos puntos de vista, incluida una perspectiva evolutiva. 
La plataforma de analisis funcional y datos se enmarca dentro de una infraestructura eficiente que conecta los diversos modulos funcionales a traves de la tecnologia de Web Services SOAP, proporcionando adicionalmente un interfaz programatico, y haciendo uso de un cluster computacional y un entorno multigrid, que ha permitido mejorar la productividad del sistema y completar el trabajo con el desarrollo y agregacion de diferentes metodologias y aplicaciones, repositorios de datos e incluso un framework de desarrollo de aplicaciones bioinformaticas. 
Esperamos que el resultado de esta tesis doctoral sea de utilidad para los investigadores del area de genomica y...
ITI-007 (2011)

The 15th Biennial Winter Workshop in Psychoses, 15–18 November 2009, Barcelona, Spain: Oral Platform Presentations
The Study of Cutaneous Melanomas in Camargue‐Type Gray‐Skinned Horses (2): Epidemiological Survey (2000)

An epidemiological survey was made on cutaneous melanomas occurring in Camargue-type, gray-skinned horses in southern France. The population investigated was composed of 264 horses, which were selected from the Camargue horse stud registry and were allowed to be examined by the owners. The presence of tumors was inspected macroscopically according to the standardized protocols of veterinary medicine specialists, and some tumors were subjected to macroscopic histopathological examination. The results indicated that: 1) the prevalence of melanomas in the overall population was 31.4%; 2) the odds ratio was obtained for an age class of 5-9 years, in which most melanomas were presumed to occur; 3) the incidence of melanomas was significantly correlated with age, giving a prevalence of 67% at ages > 15 years; 4) the size and number of tumorous lesions were significantly related to age; 5) little correlation was observed between melanoma incidence and gender; and 6) the most frequently occurring body site of these tumors was underneath the tail. Because of their frequent occurrence in shaded body regions, sun exposure was not likely to be a risk factor for melanoma formation in these horses. In view of the slightly darker skin pigmentation in these horses at younger ages, the unique characteristics of their melanocytes may be associated with melanoma formation.
Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus (2022)

Monocyte subset distribution is altered in T2DM with reduced non-classical monocytes and increased TEM percentage in the intermediate monocyte subset. Increased angiopoietin-2 levels together with increased frequency of TEMs might promote plaque vulnerability in T2DM which could however not be confirmed at tissue level in advanced atherosclerotic lesions.
A computational study on the effect of exhaust gas recirculation on auto-ignition timing of HCCI engine fuelled with N-heptane, iso-octane, ethanol and methane (2002)

The homogeneous charge compression ignition, HCCI, uses compression ignition to auto-ignite a homogeneous air/fuel mixture. Using internally trapped engine exhaust gas, IEGR, as an indirect control method, HCCI offers superior fuel economy and pollutant emission reductions. Fuel structure has direct impact on its auto-ignition performance. In this research, the effect of IEGR on auto-ignition timing of four typical fuels with distinct Octane number: N-heptane, Iso-octane, Ethanol and Methane have been studied using a single zone adiabatic combustion model and detailed chemical kinetics. It was found that the introduction of internal exhaust gas recirculation, IEGR, delays ignition timing of all four fuels, but differently. N-heptane is the most sensitive fuel to IEGR, iso-octane and ethanol has a much higher endurance, while methane is somewhere in between.
Microarray results: how accurate are they? (2002)

In view of these pitfalls, data from microarray analysis need to be interpreted cautiously.
Effects of speech coding on text-dependent speaker recognition (2002)

The introduction of speech coding systems in the telephone network raises the question of their impact on formant frequencies, fundamental frequency trajectories and other acoustics features used for text dependent speaker identification. This paper presents results of the investigation of three common speech coding systems (CELP, LPC and GSM) on the pitch and formant frequencies of speech extracted from several dialect regions of the TIMIT Speech Corpus. Voice pitch (F0) and formant frequencies (F1, F2, F3) extracted from time aligned, uncoded and coded speech samples are compared to establish the statistical distribution of error attributed to the coding system.
pH-metric and thermodynamic studies of rare earth metal chelates (2009)

包含 nitro 组(2-Hydroxy-4-nitrobenzoic 酸和 3-Hydroxy-4-nitrobenzoic 酸) 的 hydroxybenzoic 酸的质子 ligand 稳定性常数通过 Irving-Rossoti pH 滴定技术被决定。作为 ligands 包含 2-Hydroxy-4-nitrobenzoic 酸和 3-Hydroxy-4-nitrobenzoic 酸的稀土元素金属 chelates 的稳定性常数在不同离子的力量在水的媒介被学习( =0.01 ， 0.05 和 0.1 mol/L )并且温度( 298 ， 308 和 318 獡?琠敨琠慲獮潰瑲攠晦'?景????眠獡琠敨戠獥??湯捩猠牴湥瑧?慨?潮漠癢潩獵攠晦'?湯琠慲獮潰瑲漠?祄???唠摮牥琠敨漠瑰浩浵挠湯楤楴湯猠畴楤摥?桷湥椠楮楴污挠湯散瑮慲楴湯漠?祄???慷????桔?敲?瑬?景琠敨洠牯桰汯杯捩污洠摯汥湩?桳睯摥琠慨?敧敮慲汬?桴?慢歮椠?祤慮業
RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype (2018)

Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenicity have previously been restricted by relatively small sample sizes from individual trials. Here we combine data from six Phase II RTS,S trials and evaluate the relationship between HLA allele groups and RTS,S-mediated protection in controlled human malaria infections (CHMI), using multivariate logistic or linear regression. We observed significant associations between three allele groups (HLA-A<sup>∗</sup>01, HLA-B<sup>∗</sup>08, and HLA-DRB1<sup>∗</sup>15/<sup>∗</sup>16) and protection, while another three allele groups (HLA-A<sup>∗</sup>03, HLA-B<sup>∗</sup>53, and HLA-DRB1<sup>∗</sup>07) were significantly associated with lack of protection. It is noteworthy that these 'protective' allele groups are thought to be at a lower prevalence in sub-Saharan African populations than in the UK or USA where these Phase II trials occurred. Taken together, the analyses presented here give an indication that HLA genotype may influence RTS,S-mediated protective efficacy against malaria infection.
Orientation-singularity analysis and orientationability evaluation of a special class of the Stewart–Gough parallel manipulators (2013)

SUMMARY This paper addresses the orientation-singularity analysis and the orientationability evaluation of a special class of the Stewart–Gough parallel manipulators in which the moving and base platforms are two similar semi-symmetrical hexagons. Based on the half-angle transformation, an analytical polynomial of degree 13 that represents the orientation-singularity locus of this special class of parallel manipulators at a given position is derived. Graphical representations of the orientation-singularity locus of this class of manipulators are illustrated with examples to demonstrate the results. Based on the description of the orientation-singularity and nonsingular orientation region of this class of parallel manipulators, a performance index, referred to as orientationability , which describes the orientation capability of this class of manipulators at a given position, is introduced. A discretization algorithm is proposed for computing the orientationability of the special class of parallel manipulators at a given position in the workspace. Moreover, the effects of the design parameters and position parameters on the orientationability are also investigated in detail. Based on the orientationability performance index, another performance index, referred to as practical orientationability , representing the practical orientation capability of the manipulators at a given position, is introduced. In this performance index, singularities, the limitations of active and passive joints and link interferences are all taken into consideration. Furthermore, the practical orientationability of the special class of parallel manipulators studied here is also analyzed over several plane sections of the position-workspace in detail.
Inspection of aeronautics parts for shape defect detection using a multi-camera system (2008)

International audience
Operating characteristics of rotating beds (1988)

Vapor-liquid contacting in high gravitational fields offers prospects for significant reductions in the physical size, capital, and operating costs of packed towers. Pressure drops, power requirements, mass transfer coefficients and liquid residence time distributions are reported for a rotating bed separator. The beds studied were rigid, foamed aluminum, with specific surface areas ranging from 650 to 3000 m{sup 2}/m{sup 2}. Gravitational fields were varied from 50 to 300g.
Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins (2012)

Most chemotherapeutic agents are blood-brain barrier (BBB) impermeants. HIV-1-derived TAT protein variants contain a transmembrane domain, which may enable them to cross the BBB and reach the brain. Here we synthesized CAYGRKKRRQRRR, a peptide containing a cysteine moiety attached to the N terminus of the transmembrane domain (C-TAT peptide), and studied its effects in an in vitro BBB model, which we found to reflect penetration by a receptor-independent pathway. Incubation of the brain capillary endothelial cell monolayer with 0.3-0.6 μmol/ml of this C-TAT peptide, for a period of 1-2 h, destabilizes brain capillary endothelial cell monolayer and introduces the ability of impermeant therapeutic agents including high molecular weight proteins to penetrate it substantially. The cysteinyl moiety at position 1 of the C-TAT peptide contributes largely to the destabilizing potency and the penetration efficacy of impermeant substances. The destabilizing effect was reversed using heparin. In summary, experimental conditions allowing a significant increase in entry of impermeant low and high molecular weight substances from the luminal (blood) to the abluminal side (brain) were found in an in vitro BBB model reflecting in vivo protein penetrability by a receptor-independent pathway.
Unraveling the Arthus Mystery: Fc Receptors and the Holy Grail of Inflammation (2022)

Abstract This Pillars of Immunology article is a commentary on “Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade,” a pivotal article written by D. L. Sylvestre and J. V. Ravetch, and published in Science, in 1994. https://www.science.org/doi/10.1126/science.8066448.
QUASILINEAR APPROXIMATION IN THE KINETICS OF A RAREFIED PLASMA (1962)

A set of quasilinear equations is deduced from the equations with a self- consistent field for a rarefied hightemperature plasma. The equations are intended for describing the processes taking place in a weakliy turbulent plasma, that is, for the case when the spectral energy density of the plasma oscillations considerably exceeds the thermodynamical equilibrium value but remains much smaller than the plasma particle kinetic energy density. The quasi-linear equation set includes (1) an equation for the averaged distribution function of particles diffusing in phase space under the action of stray fields and (2) an equation for the rate of variation of the spectral energy density of these stray fields due to energy exchange with the particles. (auth)
605. Potential purine antagonists. Part X. Purines and pyrazolopyrimidines: comparisons of ionisation (1958)

B. M. Lynch, R. K. Robins and C. C. Cheng, J. Chem. Soc., 1958, 2973 DOI: 10.1039/JR9580002973
Supplementary Table 4 from Differentiation of Human Embryonal Carcinomas <i>In vitro</i> and <i>In vivo</i> Reveals Expression Profiles Relevant to Normal Development (2023)

Supplementary Table 4 from Differentiation of Human Embryonal Carcinomas &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; Reveals Expression Profiles Relevant to Normal Development
Early Indications of Learning Problems (1971)

(1972). Early Indications of Learning Problems. School Psychology Review: Vol. 1, No. 2, pp. 35-38.
Synthesis and potential central nervous system stimulant activity of 5,8‐methanoquinazolines and bornano‐triazines fused with imidazole and pyrimidine (2001)

Abstract Starting from 3‐chloro‐5,8‐methanoquinazoline 1 and 3‐chloro‐bornano[1,2,4]triazine 7 , the novel 5,8‐methanoquinazolines 5a‐b and bornano[1,2,4]triazines 10a‐b fused with imidazole and pyrimidine were prepared. None of these compounds showed any satisfactory central nervous system stimulant activities.