gebhart/patrepeval huggingface dataset:
Isoforms of U1-70k Control Subunit Dynamics in the Human Spliceosomal U1 snRNP (2009)

Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ten proteins, several of which are post-translationally modified and exist as multiple isoforms. Unresolved and challenging to investigate are the effects of these post translational modifications on the dynamics, interactions and stability of the particle. Using mass spectrometry we investigate the composition and dynamics of the native human U1 snRNP and compare native and recombinant complexes to isolate the effects of various subunits and isoforms on the overall stability. Our data reveal differential incorporation of four protein isoforms and dynamic interactions of subunits U1-A, U1-C and Sm-B/B'. Results also show that unstructured post-translationally modified C-terminal tails are responsible for the dynamics of Sm-B/B' and U1-C and that their interactions with the Sm core are controlled by binding to different U1-70k isoforms and their phosphorylation status in vivo. These results therefore provide the important functional link between proteomics and structure as well as insight into the dynamic quaternary structure of the native U1 snRNP important for its function.
Emerging metrics in technology transfer I. Case studies in the life sciences (2011)

Technology transfer (TT) from academia to industry is one of the key components that is required in the translation of basic research discoveries into commercial opportunities that benefit humanity. This paper examines the TT process at four premier universities and research institutions across the USA: Harvard University, Emory University, the University of Wisconsin-Madison, and The Scripps Research Institute. In this inaugural publication in a series of related publications studying multiple aspects of TT, we develop a variety of initial metrics and ratios measuring critical factors contributing to the success of TT and provide a generic model that can address certain bottlenecks in the process and enhance its efficiency.
High-resolution MRI of a peroneal intraneural ganglion cyst arising from the knee joint: illustrative case (2021)

This case adds to the mounting evidence that intraneural cyst pathology is dependent on a connection to a synovial joint as stated in the unifying theory of intraneural cyst development.
Origin-Destination Matrix Prediction via Hexagon-based Generated Graph (2021)

With the rapid development of online ride-hailing services, people have increasingly relied on platforms providing these services to travel. The corresponding companies need to accurately obtain passengers&#x0027; travel demand to allocate orders and drivers to regions. Therefore, traffic demand prediction is a critical problem of Intelligent Transportation Systems (ITS). Origin-Destination Matrix Prediction (ODMP) is a challenging extension of traffic demand prediction that needs to consider the temporal and spatial dependence of traffic data and predict the relationship between origin and destination of passengers&#x0027; demand. In this paper, we proposed a method to convert order paths of passenger demand to the hexagon-based path graph. The path graph shows the origin and the destination of the paths of a period. Specifically, considering that traffic flows are time-varying, we generate different hexagon-based path graphs for different time periods. Then, we propose a Hexagon-based Dynamic-Graph Convolutional Network (Hex D-GCN) to make the GCN suitable for dynamic graphs, in which graph connections are different in time series. Furthermore, We evaluate our model on the Didi Chuxing KDD CUP 2020 dataset and get the state-of-art performance. It is shown that our method combines the spatial correlation and temporal correlation well and also captures the passenger&#x0027;s demand pattern.
2743 Microstructures and mechanical properties of extruded Mg-(7〜9%) Al-Zn-RE-Ca alloys (2006)

Authors attempt to improve proof stresses and their anisotropic properties of Mg-Al-Zn wrought alloys by microstructural controls utilizing dynamic recrystallization and dynamic precipitation during hot extrusion. In the alloy specimens extruded at lower temperatures increasing Al and Zn contents enhance dynamic recrystallization and dynamic precipitation, resulting in grain refinement and large amount of Mg_<17> Al_<12> precipitates. As a result, the extruded Mg-9%Al-1%Zn alloy specimen shows high tensile strength of 370MPa, 0.2% tensile proof stress of 240MPa and moderate elongation of 20%, which are comparable to those of T5-treated 6N01 Al extruded alloy. Furthermore, a ratio of compressive proof stress to tensile proof stress of the as-extruded specimen improves up to a higher ratio of 0.9 than that of Mg-3%Al-1%Zn alloy specimen with no precipitation, 0.5, due to prevention of tensile twin, which easily occurs during compressive deformation even under a low applied stress perpendicular to the extrusion direction, by dynamic precipitation of Mg_<17> Al_<12> phase.
High-pressure Reactions of Quinazoline and Indoles with Dimethyl Acetylenedicarboxylate (1980)

y 8 -m e t h y l q u i n a z o l i n e , inert at 1 bar, with dj methyl acetylenedicarboxylate at 10 kbar gave tetramethyl 6e t h o x y -l O -m e t h y l -4 a H -p y r i d o [ l , 2 -a ] q ~i n a ~o l i n e -2 , 3 , 4 , 4 ~-t e t r a -
Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder (2010)

Polymorphisms in the PER3 promoter could affect its expression, leading to potential differences in the observed functions of PER3.
A Robotic Deburring Methodology for Tool Path Planning and Process Parameter Control of a Five-Degree-of-Freedom Robot Manipulator (2019)

Industrial robotics is a continuously developing domain, as industrial robots have demonstrated to possess benefits with regard to robotic automation solutions in the industrial automation field. In this article, a new robotic deburring methodology for tool path planning and process parameter control is presented for a newly developed five-degree-of-freedom hybrid robot manipulator. A hybrid robot manipulator with dexterous manipulation and two experimental platforms of robot manipulators are presented. A robotic deburring tool path planning method is proposed for the robotic deburring tool position and orientation planning and the robotic layered deburring planning. Also, a robotic deburring process parameter control method is proposed based on fuzzy control. Furthermore, a dexterous manipulation verification experiment is conducted to demonstrate the dexterous manipulation and the orientation reachability of the robot manipulator. Additionally, two robotic deburring experiments are conducted to verify the effectiveness of the two proposed methods and demonstrate the highly efficient and dexterous manipulation and deburring capacity of the robot manipulator.
Design and performance of constrained envelope continuous phase modulation (2009)

We have developed a coded modulation system with continuous phase and a small controlled envelope variation called Constrained Envelope Continuous Phase Modulation (ceCPM). For the spectrally efficient scenarios, within the ceCPM framework it is possible to find schemes with an SNR gain up to 2.5 dB over Continuous phase modulation (CPM) at symbol error probability 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> , under the same requirement on spectral confinement and spectral efficiency as for the best CPM scheme. In this paper we discuss the design process for how to obtain such ceCPM schemes, and we elaborate on the properties of these ceCPM schemes.
La projection par plasma : une revue (1989)

La qualité d'un dépôt projete par plasma dépend de nombreux paramètres que l'on commence à mieux appréhender du fait des progrès de la modélisation et de la métrologie tant des écoulements plasmas que des transferts plasma-particules ou que des conditions d'écrasement et de refroidissement des particules lors de leur impact sur le substrat ou les couches déjà déposées. Les techniques de mesure utilisdes et leurs limitations sont d'abord rappelées tant pour les jets de plasma que pour les particules en vol et l'importance des différents phénomènes intervenant dans les transferts plasma-particules est soulignée : gradients de température et de concentration d'espèces chimiques très élevés autour des particules, effets de propagation de la chaleur, notamment pour les particules céramiques, effet d'évaporation, effet de raréfaction sensible dès la pression atmosphérique. Les problèmes de distribution de taille et de vitesse d'injection des particules sont également abordés car ils conditionnent les distributions de trajectoires et donc le traitement des particules dans le jet de plasma. La génération du plasma montre d'une part 1'influence considérable de l'injection du gaz, de sa nature, du dessin de la chambre d'arc et de la tuyère ainsi que du pompage de l'air ambiant sur la longueur des jets de plasma d'arc et d'autre part les problèmes d'injection pour éviter le couplage avec la décharge dans les jets de plasmas R.E Tout ceci est illustré avec des exemples de dépôt d'alumine, de zircone, de cermet carbure et de nickel. L'écrasement des particules est ensuite abordé avec les problèmes de réactions chimiques, de trempe ultra-rapide et donc de structure cristalline des dépôts, d'adhdsion mais aussi de containtes résiduelles et de leur contrôle via les gradients de température dans les dépôts pendant le tir. Enfin quelques applications actuelles sont présentées notamment pour l'aéronautique et la mécanique.
[Diaphragmatic rupture in present-day injuries]. (1989)

In this report the authors took all material found on KBC Zemun for period from 1968 to 1988 on 43 causes traumatic rupture of diaphragms treated on this clinic. On their own experience and taking the experience of the others the authors found that: Traumatic rupture of diaphragm is a consequence of thoracoabdominal compressive trauma, which it accompanies in 3% of cases. Any traumatic rupture of diaphragm is an acute surgical state which requires an urgent surgical treatment. No other treatment is justified. Radiological method is applied in diagnosing the traumatic rupture of diaphragm. The surgical operation ought to secure a good detection of accompanying injuries. They are surgically taken care of by breaking the communication between the two cavities and, by providing their proper drainage. The major factor causing this type of traumatism presents the traffic accidents. The death rate with these traumas is very high and largely depending on accompanying injuries, reaching 20.9% in the material that we studied.
Measurement of angular parameters from the decay B0 → K⁎0μ+μ− in proton–proton collisions at s=8TeV (2018)

Angular distributions of the decay B⁰ → K$^{⁎0}$ μ⁺ μ⁻ are studied using a sample of proton–proton collisions at √s=8TeV collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 20.5fb⁻¹ . An angular analysis is performed to determine the P₁ and P$^{'}$₅ parameters, where the P$^{'}$₅ parameter is of particular interest because of recent measurements that indicate a potential discrepancy with the standard model predictions. Based on a sample of 1397 signal events, the P₁ and P$^{'}$₅ parameters are determined as a function of the dimuon invariant mass squared. The measurements are in agreement with predictions based on the standard model.
Frequency-segregated dynamic channel allocation for asynchronized TDMA/TDD frame among base stations (2002)

We propose a novel dynamic channel allocation (DCA) algorithm with a distributed control scheme for mobile radio systems in which the TDMA/TDD frames of inter-base station links are not synchronized. TDMA/TDD is one of the best radio access technologies for mobile radio systems such as PHS and DECT because the same frequency is used by the forward and reverse links and many hardware parts can be commonly used in the transmitter and the receiver. A distributed control scheme significantly facilitates dynamic channel allocation, however, it makes it difficult to synchronize TDMA frames among the base stations. This asynchronization degrades the frequency utilization because one slot may interfere with two slots of a near-by base station. Furthermore, the EIRP difference between the forward and reverse links of TDMA/TDD severely degrades the frequency utilization factor if the TDMA frame phase is not synchronized. This paper proposes a frequency-segregated dynamic channel allocation scheme that makes it possible to use some of the inactive forward link channel resources for asynchronized TDMA/TDD. Those resources cannot be utilized because of excessive interference that cannot be avoided by a conventional DCA algorithm. The proposed DCA algorithm is evaluated by computer simulations. The results indicate that the proposed DCA algorithm improves blocking probability characteristics by 10-20%. This algorithm compensates the defects of TDMA/TDD due to the asynchronized frame and unbalanced EIRP.
Development of Computer Aided Engineering for Piston Design (1989)

&lt;div class="htmlview paragraph"&gt;Computer Aided Engineering system for automotive piston design was developed which can predict total piston performance in a short time at the planning stage of piston design.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Many previous studies attempted to calculate piston performance accurately with experimental data and their main purpose was not to create a tool for piston design. The purpose of this CAE system is to provide a tool for a designer to predict total piston performance easily and rapidly without experimental data. This system has following two characteristics.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Firstly, new finite element methods were developed which can predict temperature distribution without experimental data, thermal skirt expansion for a strutted piston and skirt-to-bore contact pressure under engine operating conditions. The predicted result are accurate enough to predict piston performance at the planning stage of piston design.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Secondly, the automatic mesh generating software was developed which creates three-dimensional piston modeling in less than 30 minutes. This software was developed so that a designer who has no experience of finite element analysis can operate easily and conversationally.&lt;/div&gt;
Calorimetric Measuring Systems: Characterizing High-Frequency Power Losses in Power Electronic Components and Systems (2004)

This paper discusses the calorimetric measuring system. The calorimetric principle is one of the most promising methods for accurate power measurements. A calorimetric wattmeter provides a useful tool for use in the developments of new, energy-efficient, electrical components for industrial and consumer products. Power measurements can be performed with an accuracy of 0.2% of full-scale deflection using the proposed calorimetric measuring method.
Nitrogen affects the phosphorus response of VA mycorrhiza (1990)

Root colonization by vesicular-arbuscular (VA) mycorrhizal fungi is often suppressed by phosphorus (P) additions; however, nitrogen (N) additions have been reported to both stimulate and suppress root colonization. The objective of this research was to examine colonization of Allium cepa L. roots at a range of P and N concentrations in order to clarify the effects of these nutrients on root colonization. In the first experiment, conducted under N-limiting conditions, P addition had no effect on root colonization by Glontus etunicatum Becker & Gerdemann and increased root colonization by Gigaspora margarita Gerdemann and Trappe. In the second experiment, conducted under N-sufficient conditions, P addition suppressed colonization by G. etunicatum. In the third experiment, P and N additions were such that tissue P:N ratios ranged from 0-03 (P limiting) to 017 (N limiting). No relationship was found between P:N ratio and root colonization for two isolates of G. etunicatum. Root colonization was not affected by P addition when plants were deficient in N but, when N was sufficient, P addition suppressed root colonization. These results demonstrate that plant N stress affects the resistance of the host root to colonization by VA mycorrhizal fungi.
Denaturant mediated unfolding of both native and molten globule states of maltose binding protein are accompanied by large ΔCp's (1999)

Maltose binding protein (MBP) is a large, monomeric two domain protein containing 370 amino acids. In the absence of denaturant at neutral pH, the protein is in the native state, while at pH 3.0 it forms a molten globule. The molten globule lacks a tertiary circular dichroism signal but has secondary structure similar to that of the native state. The molten globule binds 8-anilino-1-naphthalene sulfonate (ANS). The unfolding thermodynamics of MBP at both pHs were measured by carrying out a series of isothermal urea melts at temperatures ranging from 274-329 K. At 298 K, values of deltaGdegrees , deltaCp, and Cm were 3.1+/-0.2 kcal mol(-1), 5.9+/-0.8 kcal mol(-1) K(-1) (15.9 cal (mol-residue)(-1) K(-1)), and 0.8 M, respectively, at pH 3.0 and 14.5+/-0.4 kcal mol(-1), 8.3+/-0.7 kcal mol(-1) K(-1) (22.4 kcal (mol-residue)(-1) K(-1)), and 3.3 M, respectively, at pH 7.1. Guanidine hydrochloride denaturation at pH 7.1 gave values of deltaGdegrees and deltaCp similar to those obtained with urea. The m values for denaturation are strongly temperature dependent, in contrast to what has been previously observed for small globular proteins. The value of deltaCp per mol-residue for the molten globule is comparable to corresponding values of deltaCp for the unfolding of typical globular proteins and suggests that it is a highly ordered structure, unlike molten globules of many small proteins. The value of deltaCp per mol-residue for the unfolding of the native state is among the highest currently known for any protein.
ChemInform Abstract: Domino Asymmetric Conjugate Addition—Conjugate Addition. (2014)

Abstract Diketones and phenylsulfonylketones can be obtained via the title reaction by using the corresponding enolates which undergo electrophilic trapping by nitroolefins or vinylsulfones.
Effect of Chiral Cavities Associated with Molecularly Imprinted Platinum Centers on the Selectivity of Ligand-Exchange Reactions at Platinum (2000)

The metallomonomer (vinyl dppe)Pt[(R)-Bu2BINOL] (1) was copolymerized with ethylene glycol dimethacrylate to produce the molecularly imprinted polymer (MIP) P1. The chiral imprinting ligand (R)-Bu2BINOL was removed from P1 by treatment with HCl or an excess of α,α,α-trifluoro-m-cresol, BINOL, or Br2BINOL, giving polymers P2−P5. The amount of imprinting ligand released from P1 varied inversely with the steric bulk of the cleaving agent, indicating that a distribution of Pt sites with different accessibilities exists in the MIP. Exposure of P3 (containing Pt(OAr)2 centers surrounded by (R)-Bu2BINOL-shaped cavities) to rac-BINOL, an imprinting ligand analogue, led to preferential rebinding of the imprinted enantiomer via ligand exchange. Both aggregate selectivity and extent of reaction (percent of the total Pt sites in the MIP that participated in rebinding) increased with rebinding time and with temperature, up to 69% ee and 58% Pt sites rebound, respectively. A positive linear correlation between selectivity and reactivity was observed. Open, easily accessible Pt sites were proposed to be less selective than unreactive sites because their associated chiral cavities are less well-defined and therefore less capable of shape-based enantiodiscrimination. The kinetic selectivity of the least reactive sites in P3 was assessed by sequential rebinding of rac-BINOL and then rac-Br2BINOL. Rebound BINOL was recovered from 8 to 20% of the least reactive Pt sites accessible in the MIP in 89−94% ee. All data indicate that chiral cavities (outer sphere) associated with the reactive Pt centers in these MIPs are responsible for the selectivities observed for stoichiometric ligand-exchange reactions at the metal center.
Cladding-Pumped Bismuth-Doped Fiber Laser Emitting in the Wavelength Range 1.3–1.4 μm (2022)

For the first time, the paper reports on the development of a bismuth-doped fiber laser with a generation wavelength of 1.3–1.4 μm pumped into the inner cladding of the active optical fiber by radiation of multimode semiconductor diodes at λ = 0.79 μm. The experimental data concerning the generation modes of various configurations of such laser obtained at variation in the reflectivity and spectral selectivity of used mirrors, as well as the length of active optical fiber are presented. The slope efficiency of the bismuth-doped fiber laser operating at wavelength of 1360 nm achieves 1.4% with respect to the pumping power launched into the optical fiber cladding, and the maximum output power increases 300 mW.
Automatable High Sensitivity Tracer Detection: Toward Tracer Data Enriched Production Management of Hydrocarbon Reservoirs (2021)

Abstract The development of automatable high sensitivity analytical methods for tracer detection has been one of the most central challenges to realize ubiquitous full-field tracer deployment to study reservoirs with many cross-communicating injector and producer wells. Herein we report a tracer analysis approach, inspired by strategies commonly utilized in the biotechnology industry, that directly addresses key limitations in process throughput, detection sensitivity and automation potential of state-of-the-art technologies. A two-dimensional high performance liquid chromatography (2D-HPLC) method was developed for the rapid fluorescence detection and simultaneous identification of a class of novel barcoded tracers in produced water down to ultra-trace concentration ranges (&amp;lt;1ppb), matching the sensitivity of tracer technologies currently used in the oil industry. The sample preparation process throughput was significantly intensified by judicious adaptations of off-the-shelf biopharma automation solutions. The optical detection sensitivity was further improved by the time-resolved luminescence of the novel tracer materials that allows the negation of residual background signals from the produced water. To showcase the potential, we applied this powerful separation and detection methodology to analyze field samples from two recent field validations of a novel class of optically detectable tracers, in which two novel tracers were injected along with a benchmarking conventional fluorobenzoic acid (FBA)-based tracer. The enhanced resolving power of the 2D chromatographic separation drastically suppressed the background signal, enabling the optical detection of a tracer species injected at 10x lower concentration. Further, we orthogonally confirmed the detection of this tracer species by the industry standard high-resolution accurate mass spectrometry (HRAM) technique, demonstrating comparable limits of detection. Tracer detection profile indicated that the transport behavior of the novel optical tracers through highly saline and retentive reservoir was similar to that of FBAs, validating the performance of this new class of tracers. Promising steps toward complete automation of the tracer separation and detection procedure have drastically reduced manual interventions and decreased the analysis cycle time, laying solid foundation to full-field deployment of tracers for better reservoir characterizations to inform decisions on production optimization. This paper outlines the automatable tracer detection methodology that has been developed for robustness and simplicity, so that efficient utilization of the resultant high-resolution tracer data can be applied toward improving production strategy via intelligent and active rate adjustments.