gebhart/patrepeval huggingface dataset:
Additive Manufacturing Advances to Facilitate Novel Robot and Remote System Construction (2023)

Additive manufacturing (AM) in both polymer and metal has advanced to the point where it can substantially facilitate robot and remote system design and implementation. While AM is not a panacea to fix bad design concepts, properly used AM can create features and capabilities otherwise not possible in machined or cast products. AM design rules are still being developed and must be applied differently based on the process and purpose of the final component, but progress is being made in practical implementation. Polymer-based AM has been available commercially for quite some time and is regularly used to facilitate prototyping and test fitting of parts later to be fabricated in metal or to produce low production quantity parts that do not require high structural strength. However Oak Ridge National Laboratory (ORNL) has pioneered large scale polymer additive manufacturing with sufficient strength to print a car and frame, a small house, a “wet” submarine, and tooling to mold wind generator blades. While polymer processes use a variety of materials, all polymer printers basically lay down a heated extruded bead of a certain width and height. Print resolution is based on the deposition rate of the printer. The larger the deposition rate, the lower the print resolution. Large scale polymer builds often rely on post processing (machining) to provide a smooth finish to the part surface.Metal printing processes are much more diverse than polymer print processes. Electron beam (ebeam), laser, and binder jet are common methods to fuse metal powder-based systems. Metal powder spray can be done with laser or plasma. While metal powder systems produce high definition parts, part size is limited. Larger parts are currently done with wire feed systems based on laser or arc (metal inert gas (MIG) or tungsten inert gas (TIG)) processes. Part definition decreases, but part size can be on the order of tens of cubic feet and hundreds of pounds.Two implementation examples are presented in this paper to illustrate the possibilities and to identify issues that remain. A dual arm hydraulic manipulator was printed in titanium using the ebeam process. All hydraulics and electrical cabling passageways were printed into the manipulator; there are no external hoses or cables. The distal link of an excavator arm was printed using a wire feed metal inert gas (MIG) process. The excavator was then used for digging as part of an equipment exposition validating the metallurgy of the printed part.
Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t (2005)

Cell therapy has demonstrated the potential to restore injured myocardium. A reliable in vivo imaging method to localize transplanted cells and monitor their restorative effects will enable a systematic investigation of this therapeutic modality. The dual MRI capability of imaging both magnetically labeled mouse embryonic stem cells (mESC) and their restorative effects on cardiac function in a murine model of acute myocardial infarction is demonstrated. Serial in vivo MR detection of transplanted mESC and monitoring of the mESC-treated myocardium was conducted over a 4-week period using a 1.5 T clinical scanner. During the 4-week duration, the mESC-treated myocardium demonstrated sustained improvement of the left ventricular (LV) ejection fraction and conservation of LV mass. Furthermore, no significant difference of their restorative effects on the cardiac function was created by the magnetic labeling of mESC. Thus, in vivo MRI enables simultaneous detection of transplanted mESC and their therapeutic effect on the injured myocardium.
Determination of Rosuvastatin and Ezetimibe in a Combined Tablet Dosage Form Using High-Performance Column Liquid Chromatography and High-Performance Thin-Layer Chromatography (2010)

This paper describes validated HPLC and HPTLC methods for the simultaneous determination of rosuvastatin (ROS) and ezetimibe (EZE) in a combined tablet dosage form. The isocratic RP-HPLC analysis was performed on a Chromolith C18 column (100 x 6 mm id) using 0.1% (v/v) orthophosphoric acid solution (pH 3.5)-acetonitrile (63 + 37, v/v) mobile phase at a flow rate of 1 mL/min at ambient temperature. Quantification was carried out using a photodiode array UV detector at 245 nm over the concentration range of 0.5-10 microg/mL for ROS and EZE. The HPTLC separation was carried out on an aluminum-backed sheet of silica gel 60F(254) layers using n-butyl acetate-chloroform-glacial acetic acid (1 + 8 + 1, v/v/v) mobile phase. Quantification was achieved with UV densitometry at 245 nm over a concentration range of 0.1-0.9 micro/spot for ROS and EZE. The analytical methods were validated according to International Conference on Harmonization guidelines. Low RSD values indicated good precision. Both methods were successfully applied for the analysis of the drugs in laboratory-prepared mixtures and commercial tablets. No chromatographic interference from the tablet excipients was found. These methods are simple, precise, and sensitive, and are applicable for simultaneous determination of ROS and EZE in pure powder and tablets.
Affinity Partitioning of Phosphofructokinase from Baker's Yeast Using Polymer-Bound Cibacron Blue F3G-A (1983)

1. Phosphofructokinase from baker's yeast is partitioned between the phases of an aqueous two-phase system, containing dextran (Mr = 500000) and poly(ethyleneglycol) (Mr = 6000), in favour of the dextran-rich phase. By covalent binding of the dye Cibacron blue F3G-A to poly(ethyleneglycol) the enzyme can be extracted to the phase rich in this polymer, i.e. affinity partitioning. 2. The affinity partitioning effect, measured as the logarithmic increase of the partition coefficient by introducing polymer-bound Cibacron blue, depends on several factors. The influence of dye-polymer concentration, polymer concentration, polymer molecular weight, kind of salt and salt concentration, pH and temperature has been studied. 3. The effect of ATP, ADP, AMP, ITP, fructose 1,6-bis-phosphate and fructose 6-phosphate show large differences in the binding strength of these substances to the Cibacron blue binding sites. AMP cannot compete with Cibacron blue while ATP is strongly competing. 4. The use of affinity partitioning for enzyme isolation and determination of ligand binding is discussed, as well as possible mechanisms concerning this type of liquid/liquid extraction.
Thin-film metal hydrides for solar energy applications (2012)

Thin-film metal hydrides may become important solar energy materials in the future. This thesis demonstrates interesting material properties of metal hydride films, relevant for applications as semiconducting materials for photovoltaic (PV) solar cells and for regulation of light using smart window technology.
Possible Involvement of Endogenous Opioid Peptides in the Inhibition of Arginine Vasopressin Release by γ-Aminobutyric Acid in Conscious Rats (1991)

We examined the effects of gamma-aminobutyric acid (GABA) and naloxone, a potent opioid antagonist, on arginine vasopressin (AVP) secretion in conscious rats in order to study the relationship of GABA and endogenous opioid peptides in the regulation of AVP secretion. Intracerebroventricular administration of GABA caused a time- and dose-dependent decrease in the plasma concentration of AVP that was elevated by hypertonic saline injection, whereas it did not affect the basal AVP. Pretreatment with naloxone (10 mg/kg) significantly attenuated the inhibitory effect of GABA (100 micrograms) on AVP release. These results suggest that GABA produces an inhibition of AVP release stimulated by hypertonic saline, and that this inhibitory effect may be mediated at least in part by the endogenous opioid systems.
Intraperitoneal carboplatin: rationale and experience. (1992)

We conducted a phase I/II trial of intraperitoneal (IP) carboplatin in 27 patients with advanced gynecologic malignancies. This was based on the known activity of carboplatin in ovarian cancer and pharmacologic measurements that predict a favorable ratio of IP to plasma drug exposure when carboplatin is administered by the IP route. All patients had extensive prior therapy with cisplatin (mean dose, 554 mg/m2). Starting dose was 200 mg/m2, which was escalated to 500 mg/m2. Patients with compromised renal function (creatinine clearance 30 to 60 mL/min) had slower escalations than patients with creatinine clearances greater than 60 mL/min. Myelosuppression, especially thrombocytopenia, was the dose-limiting toxicity. In pretreated patients, we recommend a starting dose of 400 mg/m2. Patients with creatinine clearances of 30 to 60 mL/min should start at the lower dose of 200 mg/m2. This is in general agreement with the results of other trials of IP carboplatin. Measurements of IP carboplatin in preclinical studies predict less tissue penetration by carboplatin than the parent compound cisplatin. Nevertheless, in our series of heavily pretreated patients receiving IP carboplatin, eight patients remained free of disease progression for more than 2 years. Further trials of IP carboplatin are indicated.
High-aperture beams: reply to comment (2007)

Seshadri's claim [J. Opt. Soc. A23, 3238 (2006)] that the singularity in the simple complex-source point model is not nonphysical is disputed. The branch cut behavior is further discussed. Two different forms for the complex-source point model for a Gaussian beam are identified, corresponding to different choices for the sign of a square root or in terms of oblate spheroidal coordinates to two different branch cuts. One of these solutions corresponds to a beamlike solution, while the second gives a wave that radiates outward from the source. Both exhibit nonphysical singularities. These singularities are avoided by using a complex-source/sink model. The choice of branch cut is also important in defining the oblate spheroidal beams, based on spheroidal harmonics.
Pneumonia with Serological Evidence of Acute Infection with the Chlamydia-like Microorganism “Z” (1997)

"Z" is a recently discovered microorganism that may belong to a new genus in the family Chlamydiaceae. Using an ELISA test we developed, we measured levels of serum antibody against "Z" for 308 paired sera obtained from adult patients hospitalized with community-acquired pneumonia (CAP). In 114 patients (37%), serological evidence of past infection with "Z" was found. In eight patients (2.6%) there was serological evidence of acute infection with this pathogen. In four of these eight patients, no other pathogen for CAP was identified despite an intensive serological investigation encompassing 13 etiological agents. The four patients were about 30 yr old, and three of them had no history of chronic illness. Their illness was characterized by high fever, a nonproductive cough, gastrointestinal symptoms, a shift to the left in the white blood cell count, and a prompt, dramatic response to erythromycin therapy. We conclude that the microorganism "Z", or a close variant, is infectious for humans, in some cases causing CAP. In these cases the disease is mild and responds quickly to treatment with erythromycin.
Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines (2012)

The search for effective plant-derived anti-cancer agents or their synthetic analogs has continued to gain interest in drug development. The anti-cancer activity of parthenolide (PTL) isolated from Tanacetum parthenium, has been attributed to the presence of α-methylene-γ-lactone skeleton. In the present study we aimed to investigate the anti-cancer potential of a new synthetic compound, 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6), with the same as in PTL α-methylene-γ-lactone motif, on two breast cancer cell lines, MCF-7 and MDA-MB-231. For comparison, PTL was included in the study. PTL and MZ-6 reduced the number of viable MCF-7 and MDA-MB-231 cells, with half maximal inhibitory concentration values between 6 and 9 μM. Both compounds dose-dependently inhibited incorporation of [(3)H]thymidine, up-regulated Bax and down regulated Bcl-2 mRNA. The levels of the end product of lipid peroxidation, malondialdehyde, were significantly higher. In MCF-7 cells, MZ-6 induced early apoptosis and cell cycle arrest in G0/G1 phase. The effect produced by MZ-6 was much stronger compared with PTL. In MDA-MB-231 cells, both tested compounds had similar effect and induced mostly late apoptosis. In conclusion, the observed anticancer activity makes MZ-6 an attractive drug candidate and shows that simple analogs of α-methylene-γ-lactones can be good substitutes for more complex structures isolated from plants.
THE MOLECULAR BASIS OF ANTIBODY FORMATION (1960)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
157 nm Resist Materials: A Progress Report. (2000)

The goal or this work has been to study candidate fluorocarbon materials that might serve as platforms from which to design 157nm resists. A specific goal of the work has been to identify transparent candidate materials that might provide a polymer backbone and acceptable etch resistance. Several model compounds were synthesized and their vacuum UV spectra were measured in the gas phase. Substituted norbornane (bicyclo[2.2.1]heptane) was of significant interest in this regard because we had used this structure successfully in the design systems for 193nm exposure. Surprisingly, 2-monofluoronorbornane is unstable and undergoes spontaneous dehydrohalogenation upon exposure to glass in vacuo. However, 2, 2-substitution with fluorine and with other electron withdrawing groups such as trifluoromethyl and even carbonyl groups gives norbornyl derivatives with greatly improved transparency at 157nm. These observations led to the design a variety of novel norbornenes that can be polymerized by metal catalyzed addition polymerization to give etch resistant polymer platforms with greatly improved transparency at 157nm and led to the study of acrylic co-polymers derived from 2-(trifluoromethyl)acrylic acid.
Looking Beyond the Digital Divide (2005)

Book Review: Digital Nation: Toward an Inclusive Information Society, Anthony G. Wilhelm, Cambridge, Mass., MIT Press, 2004, 184 pages.\nA review of Anthony G. Wilhelm's Digital Nation: Toward an Inclusive Information Society, MIT Press, 2004. An important attempt to frame the debate about the importance of technological literacy, this book explores world-wide successes and failures to bring technology to the masses and provides a plan to accomplish it in the United States.
Multiple Resolution Texture Analysis and Classification (1984)

Textures are classified based on the change in their properties with changing resolution. The area of the gray level surface is measured at serveral resolutions. This area decreases at coarser resolutions since fine details that contribute to the area disappear. Fractal properties of the picture are computed from the rate of this decrease in area, and are used for texture comparison and classification. The relation of a texture picture to its negative, and directional properties, are also discussed.
CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia (2022)

Summary Most tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment, demonstrate an immunosuppressive phenotype and contribute to tumor progression, treatment resistance and poor clinical outcomes 1,2 . Due to their functional plasticity, these cells could be reprogrammed to acquire a pro-inflammatory phenotype and promote tumor clearance 1 . Several therapeutic approaches targeting TAMs to alleviate their immunosuppressive properties or to harness their tumoricidal capacities have been developed 3,4 . Inhibition of interactions between phagocytic inhibitor receptors on macrophages and “don’t eat me signals” on cancer cells, which promotes cancer cell engulfment, showed therapeutic benefits for several tumor types 4–6 . Investigating mechanisms involved in macrophage-mediated phagocytosis of tumor cells, we demonstrate here a key role for the cyclin-dependent kinase inhibitor CDKN1A (p21). Through transcriptional repression of SIRPα (Signal-Regularity Protein α), which encodes a phagocytic inhibitor, CDKN1A promotes the ability of monocyte-derived macrophages (MDMs) to engulf leukemic cells. In turn, these MDMs acquire a pro-inflammatory phenotype that extends to surrounding MDMs in an Interferon γ (IFNγ)-dependent manner. Human monocytes genetically engineered to overexpress p21 (p21TD-Mo) differentiate into anti-inflammatory MDMs that are primed for leukemic cell phagocytosis when transferred into mice xenografted with patient-derived T-cell acute lymphoblastic leukemia (T-ALL) cells. After leukemic cell engulfment, engineered macrophages undergo a pro-inflammatory activation, reducing leukemic burden and substantially prolonging survival of mice. These results reveal p21 as a trigger of phagocytosis-guided pro-inflammatory reprogramming of TAMs and demonstrate the potential for p21TD-Mo-based cell therapy in cancer immunotherapy.
Variational mode decomposition based denoising in side channel attacks (2016)

In this paper, we present two kinds of noise reduction methods for improving the attack performance in side channel attacks (SCA). One is wavelet transform combined with variational mode decomposition (VMD-WT), the other is an iterative variation mode decomposition combined with wavelet transform (IVMD-WT). We test them both on simulated piece-regular signal and practical leakages including software implementation and hardware implementation of AES. Results of all experiments show that the proposed methods outperform widely used wavelet transform and can improve the success rate of correlation power analysis (CPA) significantly. The proposed methods not only are more suitable to general condition but also are superior to some existing methods from the view point of usability and efficiency for denoising.
Study of Si Nanowire Surface Cleaning (2019)

The Gate-All-Around (GAA) Field-Effect-Transistor (FET) is proposed as a promising candidate to replace Fin FET. In GAA architecture, Si Nanowires (NWs), which are fabricated by selective etching of SiGe from Si/SiGe multilayer fin structure, are used as channel. One of the concerns for fabricating GAA architecture is residual Ge, which is diffused SiGe from the Si/SiGe multilayer stack, in the Si NWs after their release. This Ge residue is a concern, since it could cause a degradation in device performance. The roughness of the Si NWs' surface, which is a further factor in the degradation of device performance, was also examined. In this study, residual Ge removal and surface roughness with commodity chemistry was investigated. Finally, it was confirmed that residual Ge could be completely removed from Si without increasing Si surface roughness by dH2O2.
A pivotal role of nitric oxide in endothelial cell dysfunction (2000)

The functional role of the vascular endothelium is a subject of growing interest and appreciation. Some of the key functions of the endothelium are modulated by the activity and expression of endothelial nitric oxide synthase (eNOS), suggesting a role for this enzyme in endothelial dysfunction. Several well-known angiogenic stimulators exert their effect only in the presence of the functional eNOS. In this setting NO production is responsible for the scalar podokinetic cell motility, which is a prerequisite for the acquisition of vectorial movement when guidance cues are applied. The mode of this NO action appears to lie in the accelerated turnover of focal adhesions through the process of activation/inactivation of protein tyrosine phosphatases. Localization of eNOS to the caveolar domains, in the proximity of clustered beta1 integrins, provides an additional level of regulatory complexity through the modulation of caveolar dynamics and the state of caveolin oligomerization. Therefore, eNOS serves various important functions in the endothelium and is a putative target for therapeutic interventions.
Structural Modification To Minimize Response Of Electro-Optical Systems To Random Excitation (1987)

Future electro-optical space systems require low ambient vibration response levels in the presence of numerous broad and narrow-band disturbances. A structural design methodology which addresses this vibration suppression problem is devised. Dynamic response is described in terms of random vibration theory. Input power spectral density is represented compactly in terms of its poles and zeroes. Output power spectral density is integrated in closed form using residue theory to obtain root mean square re-sponse. An optical performance index based on this response is minimized subject to a constraint on structural weight. That structural design which provides the best combination of stiffening, tuning and mode shape changes is thus employed. Large gains in optical performance with little or no weight penalty are demonstrated.
Thru-silicon interconnect technology (2002)

Wafer-level packaging (WLP) is forecast to be less expensive than die-level packaging, though many fundamentally new technologies are needed to fulfil this potential. For a complete WLP process flow to be cost-effective, all newly developed technologies should be simple and inexpensive to implement in high-volume manufacturing. Chip-scale packages (CSPs) produced with a WLP process flow are particularly advantageous when combined with flip-chip/BGA connections, since direct-chip attach (DCA) parts can thus be produced entirely by a wafer-fab. A new process technology-atmospheric downstream plasma (ADP) gas etching-allows for the WLP formation of backside thru-silicon contacts for DCA applications. Thru-silicon designs and manufacturing process flows are introduced as means to produce 3D wafer level packaging solutions. Standard silicon IC manufacturing unit-processes must be combined into robust process-flows to allow for the rapid deployment of wafer-level packaging throughout the industry.
Enhanced‐output‐power broadband terahertz‐wave emitter based on slot‐antenna‐integrated uni‐travelling‐carrier photodiode (2015)

Resonant slot‐antenna‐integrated uni‐travelling‐carrier photodiodes were developed for enhancing terahertz (THz)‐wave output powers while maintaining relatively broad bandwidths. Their output powers were two to three times larger at their peaks than those of a non‐resonant bowtie‐antenna‐integrated device. The output powers were enhanced at frequencies from 900 GHz to 1.6 THz for a narrow‐slot device and from 350 to 850 GHz for a wide‐slot device. Typical output powers were 3.5 μW at 1.25 THz and 28 μW at 700 GHz for a photocurrent of 10 mA with a bias voltage of only −0.4 V.
Integrated photoelectrochemical energy storage: solar hydrogen generation and supercapacitor (2012)

Current solar energy harvest and storage are so far realized by independent technologies (such as solar cell and batteries), by which only a fraction of solar energy is utilized. It is highly desirable to improve the utilization efficiency of solar energy. Here, we construct an integrated photoelectrochemical device with simultaneous supercapacitor and hydrogen evolution functions based on TiO(2)/transition metal hydroxides/oxides core/shell nanorod arrays. The feasibility of solar-driven pseudocapacitance is clearly demonstrated, and the charge/discharge is indicated by reversible color changes (photochromism). In such an integrated device, the photogenerated electrons are utilized for H(2) generation and holes for pseudocapacitive charging, so that both the reductive and oxidative energies are captured and converted. Specific capacitances of 482 F g(-1) at 0.5 A g(-1) and 287 F g(-1) at 1 A g(-1) are obtained with TiO(2)/Ni(OH)(2) nanorod arrays. This study provides a new research strategy for integrated pseudocapacitor and solar energy application.