gebhart/patrepeval huggingface dataset:
ERRATUM (2015)

The authors apologize and state that in the original article “WEB-DL Endovascular Treatment of Wide-Neck Bifurcation Aneurysms: Short- and Midterm Results in a European Study” by B. Lubicz, J. Klisch, J.-Y. Gauvrit, I. Szikora, M. Leonardi, T. Liebig, N.P. Nuzzi, E. Boccardi, F.D. Paola, M.
Photographic and Luminometric Detection of Luciferase Reporter Phages for Drug Susceptibility Testing of Clinical Mycobacterium tuberculosis Isolates (2003)

Luciferase reporter phages (LRPs) have proven to be efficient tools for drug susceptibility testing of Mycobacterium tuberculosis. Luminometric detection of LRP activity offers higher sensitivity and quantitative results, while a Polaroid film detection method offers a "low-tech" inexpensive alternative that is called the Bronx box. In this work we evaluated, improved, and compared the performance of the luminometer and the Bronx box formats for drug susceptibility testing with LRPs by using 51 clinical isolates of M. tuberculosis, with the agar proportion method (PM) serving as reference. The sensitivity in detecting resistance to isoniazid and rifampin, antibiotics that define multidrug resistance (MDR), was 100% for both methods. The turnaround time for results was reduced from 3 weeks for PM to 54 or 94 h for luminometry or the Bronx box, respectively. These results support the utility of LRPs as a screening test for the surveillance of MDR tuberculosis.
Evaluation of lignins and particle films as solar protectants for the granulovirus of the codling moth,Cydia pomonella (2008)

Abstract The identification of effective solar protectants for field application of the codling moth, Cydia pomonella (L.), granulovirus (CpGV) is of interest to improve its efficacy and commercial viability as a biological pesticide. We evaluated several materials as potential adjuvants to protect CpGV from ultraviolet degradation. In laboratory tests with a solar simulator (9.36×106 J/m2), the addition of kaolin clay (Surround® WP at 3 and 6%, w/v), a paraffin wax-based emulsion (SPLAT™ at 5%, v/v), and a bark extract trans-cinnamaldehyde combined with a film agent (both at 1%, v/v) did not significantly reduce larval entries or increase larval mortality in irradiated apples that were treated with a commercial CpGV product (Cyd-X). In semi-field tests in an apple orchard, a spray-dried lignin formulation containing CpGV (6.57×1012 OBs/ha) and a lignin-based adjuvant used with Cyd-X (both applied at 4.7–5.6 kg lignin/ha) significantly improved residual activity of CpGV compared with Cyd-X alone applied at the same rate. However, the benefits were short lived and could not be detected after 7 days. In orchard tests, we evaluated two additional refined lignin-products (Lignosulfonate and Vanisperse™ CB at 5.61 kg/ha) and two particle film materials (kaolin clay, ‘Cocoon™’, and calcium with boron ‘Eclipse™’) as adjuvants for UV protection of Cyd-X (6.57×1012 OBs/ha) in tests against a dense codling moth infestation. Although all virus treatments were highly effective (causing ≥90% larval mortality), no significant effects of the adjuvant treatments could be detected. In these latter tests, the use of a silicone based wetting agent at 0.025% (v/v) may have been beneficial at increasing mortality among older larvae inside the fruit.
Origin of the neurotensinergic innervation of the rat basal forebrain studied by retrograde transport of cholera toxin (1998)

Basal forebrain cholinergic neurons project to the hippocampus and cerebral cortex where they play an important role in cortical activation, attention, and memory. These neurons have been shown to express functional neurotensin receptors and to receive a dense neurotensinergic innervation. In the present study, we investigated the origin of this innervation by combining retrograde transport of cholera toxin with immunohistochemical detection of neurotensin. After injection of cholera toxin in the anterior substantia innominata and diagonal band of Broca, retrogradely labelled cells were widely distributed throughout forebrain limbic structures. Only a small proportion of these cells, located (by decreasing order of frequency) in the lateral septum, medial preoptic area, rostral hypothalamus, nucleus accumbens, and rostral basal forebrain, were dually labelled for neurotensin. After injection of cholera toxin in the posterior substantia innominata and magnocellular preoptic nucleus, retrogradely labelled cells were detected throughout the limbic forebrain and ponto-mesencephalic tegmentum. Here again, only a small proportion of these cells, located (by decreasing order of frequency) in the nucleus accumbens, lateral septum, rostral basal forebrain, hypothalamus, bed nucleus of the stria terminalis, supramammilliary nucleus, ventral tegmental area, and raphe complex co-localized neurotensin. In view of the burst generating properties of neurotensin on basal forebrain cholinergic neurons, our results suggest that neurotensin projections may be part of the septo-hippocampo-septal loop regulating hippocampal theta activity. More caudally, neurotensin axons originating from the lateral hypothalamus and pontomesencephalic tegmentum may contribute to the contingent of ascending reticular formation fibers involved in the regulation of the sleep-wake cycle. J. Comp. Neurol. 391:30–41, 1998. © 1998 Wiley-Liss, Inc.
Pumping approximately integrable systems (2017)

Weak perturbations can drive an interacting many-particle system far from its initial equilibrium state if one is able to pump into degrees of freedom approximately protected by conservation laws. This concept has for example been used to realize Bose-Einstein condensates of photons, magnons and excitons. Integrable quantum systems, like the one-dimensional Heisenberg model, are characterized by an infinite set of conservation laws. Here, we develop a theory of weakly driven integrable systems and show that pumping can induce large spin or heat currents even in the presence of integrability breaking perturbations, since it activates local and quasi-local approximate conserved quantities. The resulting steady state is qualitatively captured by a truncated generalized Gibbs ensemble with Lagrange parameters that depend on the structure but not on the overall amplitude of perturbations nor the initial state. We suggest to use spin-chain materials driven by terahertz radiation to realize integrability-based spin and heat pumps.
ЗАДАЧИ БАССЕЙНОВОГО МОДЕЛИРОВАНИЯ НА РАЗНЫХ ЭТАПАХ ГЕОЛОГО-РАЗВЕДОЧНЫХ РАБОТ (2015)

Article is devoted to the use of basin modeling, which is increasingly used in conducting geological exploration for oil and gas in Russia. Basin modeling should be performed in all stages of exploration work, with each stage of this work correspond to their tasks. Regional stage comprises the steps of prediction and evaluation of oil and gas bearing zones of oil and gas. On search and evaluation stage become objects of study areas with established or possible oil and gas content, as well as prepared traps and open fields. The exploration stage studies industrial fields, clarifies their structure and reserves. Effective geological exploration process is a process cycle where the economy plays an important role - assessment of profitability of the whole project.
Species intelligence: Hazards of structural parallels (1990)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Role of the GTPase Rab1b in Ebolavirus Particle Formation (2010)

The Ebolavirus matrix protein VP40 is essential for virion assembly and egress. Recently, we reported that the coat protein complex II (COPII) transport system plays an important role in the transport of VP40 to the plasma membrane. Here, we show that dominant-negative mutants of the GTPase Rab1b interfere with VP40-mediated particle formation. Rab1b activates GBF1 (Golgi-specific BFA [brefeldin A] resistance factor 1), a critical factor in the assembly of COPI vesicles. Activated GBF1 stimulates ARF1 (ADP ribosylation factor 1), which recruits coat protein to cellular membranes for the assembly of COPI vesicles. Here, we demonstrate that GBF1 and ARF1 are involved in Ebolavirus virion formation, suggesting that both the COPII and COPI transport systems play a role in Ebolavirus VP40-mediated particle formation. These findings provide new insights into the cellular pathways employed for Ebolavirus virion formation.
Reproducibility of Skin Temperature Response after Cold Stress Test Using the Game Ready System: Preliminary Study (2021)

The objective of this preliminary study was to determine the reproducibility of lower limbs skin temperature after cold stress test using the Game Ready system. Skin temperature of fourteen participants was measured before and after cold stress test using the Game Ready system and it was repeated the protocol in four times: at 9:00, at 11:00, at 19:00, and at 9:00 h of the posterior day. To assess skin temperature recovery after cold stress test, a logarithmic equation for each region was calculated, and constant (β<sub>0</sub>) and slope (β<sub>1</sub>) coefficients were obtained. Intraclass correlation coefficient (ICC), standard error (SE), and within-subject coefficient of variation (CV) were determined. No differences were observed between measurement times in any of the regions for the logarithmic coefficients (<i>p</i> > 0.38). Anterior thigh (β<sub>0</sub> ICC 0.33-0.47; β<sub>1</sub> ICC 0.31-0.43) and posterior knee (β<sub>0</sub> ICC 0.42-0.58; β<sub>1</sub> ICC 0.28-0.57) were the regions with the lower ICCs, and the other regions presented values with a fair and good reproducibility (ICC > 0.41). Posterior leg was the region with the better reproducibility (β<sub>0</sub> ICC 0.68-0.78; β<sub>1</sub> ICC 0.59-0.74; SE 3-4%; within-subject CV 7-12%). In conclusion, cold stress test using Game Ready system showed a fair and good reproducibility, especially when the posterior leg was the region assessed.
ChemInform Abstract: Intercalation of Multiple Carbon Atoms Between the Carbonyls of α‐Diketones. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Energy Cost of Rehabilitation Calisthenics (1979)

This study examined the relationship between total energy cost and cardiac effort for a set of graded calisthenics that have been used in cardiac rehabilitation programs. Cardiac effort was quantified by calculating myocardial oxygen cost from the product of heart rate and systolic blood pressure. Total energy cost was determined by measuring oxygen uptake during steady-state exercise. Results indicate that total energy-cost values accurately reflect the cardiac effort required during the performance of these calisthenic exercises by normal subjects.
[Pharmacologic concepts for clinical use of prostaglandin E1]. (1991)

This presentation reviews pharmacological properties of PGE1 which may be relevant for its clinical use to treat peripheral arterial occlusive diseases. These include inhibition of receptor-mediated stimulation of human PMN and platelets which is caused via cAMP as intracellular second messenger. Further actions are an endothelium-independent vessel relaxation and a yet poorly defined "cytoprotective" action, i.e. an improved organ and tissue preservation without direct relation to cell metabolism or blood flow. Recent evidence suggests that these biological effects of PGE1 may also include one of its metabolite, i.e. PGE0. Details about the biological activities of this compound in comparison to PGE1 will be presented separately at this meeting. It is concluded that the beneficial effects of PGE1 in treatment of peripheral arterial occlusive disease are a multifactorial event and might involve PGE0, in particular at intravenous administration of high doses.
Current therapeutic options for endodontic biofilms (2010)

Microbial biofilms in the infected root canal space are the primary cause of apical periodontitis. Root canal treatment therefore aims to either remove the biofilms from the root canal or kill all of the microbes in the biofilms. Instrumentation mechanically removes or disrupts biofilm organization and creates sufficient space in the canal to allow effective irrigation and disinfection to occur. While none of the mechanical or chemical factors alone can predictably eradicate the infective agents, their combined action under optimal efforts is the key factor for long‐term success of endodontic treatment and healing of the lesion. In this article, the role and impact of various mechanical (physical) and chemical means of attacking root canal biofilms are discussed in light of relevant literature ( F ig. ). Green symbols: factors that effect the development and characteristics of endodontic biofilms. Red symbols: factors that are important in eradication of biofilms and biofilm bacteria. figure
ChemInform Abstract: Suzuki and Heck Reactions Catalyzed by Preformed Palladium Clusters and Palladium/Nickel Bimetallic Clusters. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bacterial/archaeal/organellar polyadenylation (2010)

Although the first poly(A) polymerase (PAP) was discovered in Escherichia coli in 1962, the study of polyadenylation in bacteria was largely ignored for the next 30 years. However, with the identification of the structural gene for E. coli PAP I in 1992, it became possible to analyze polyadenylation using both biochemical and genetic approaches. Subsequently, it has been shown that polyadenylation plays a multifunctional role in prokaryotic RNA metabolism. Although the bulk of our current understanding of prokaryotic polyadenylation comes from studies on E. coli, recent limited experiments with Cyanobacteria, organelles, and Archaea have widened our view on the diversity, complexity, and universality of the polyadenylation process. For example, the identification of polynucleotide phosphorylase (PNPase), a reversible phosphorolytic enzyme that is highly conserved in bacteria, as an additional PAP in E. coli caught everyone by surprise. In fact, PNPase has now been shown to be the source of post-transcriptional RNA modifications in a wide range of cells of prokaryotic origin including those that lack a eubacterial PAP homolog. Accordingly, the past few years have witnessed increased interest in the mechanism and role of post-transcriptional modifications in all species of prokaryotic origin. However, the fact that many of the poly(A) tails are very short and unstable as well as the presence of polynucleotide tails has posed significant technical challenges to the scientific community trying to unravel the mystery of polyadenylation in prokaryotes. This review discusses the current state of knowledge regarding polyadenylation and its functions in bacteria, organelles, and Archaea.
Kinetic Studies on the Heat Inactivation of Peroxidase in Sweet Corn a (1962)

SUMMARY A kinetic procedure employing D values was used instead of the usual end‐point method to study heat inactivation of peroxidase in whole‐kernel sweet corn. Results at 150–200°F indicated that a heat‐labile fraction and a heat‐stable fraction were being inactivated. The resistant fraction represented 5% of total enzyme activity, and was concentrated in the pericarp. Increasing the blanch time at 200°F from 2 to 5 min decreased residual enzyme activity from 3.3% to 1.7%. Inactivation of the heat‐resistant fraction at 210–290°F also followed a first‐order reaction. The phantom inactivation‐time curve showed that an HTST process based on microbial destruction could leave residual enzyme activity.
Cocrystals of the antimalarial drug 11-azaartemisinin with three alkenoic acids of 1:1 or 2:1 stoichiometry (2018)

The stoichiometry, X-ray structures and stability of four pharmaceutical cocrystals previously identified from liquid-assisted grinding (LAG) of 11-azaartemisinin (11-Aza; systematic name: 1,5,9-trimethyl-14,15,16-trioxa-11-azatetracyclo[10.3.1.0<sup>4,13</sup>.0<sup>8,13</sup>]hexadecan-10-one) with trans-cinnamic (Cin), maleic (Mal) and fumaric (Fum) acids are herein reported. trans-Cinnamic acid, a mono acid, forms 1:1 cocrystal 11-Aza:Cin (1, C<sub>15</sub>H<sub>23</sub>NO<sub>4</sub>·C<sub>9</sub>H<sub>8</sub>O<sub>2</sub>). Maleic acid forms both 1:1 cocrystal 11-Aza:Mal (2, C<sub>15</sub>H<sub>23</sub>NO<sub>4</sub>·C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>), in which one COOH group is involved in self-catenation, and 2:1 cocrystal 11-Aza<sub>2</sub>:Mal (3, 2C<sub>15</sub>H<sub>23</sub>NO<sub>4</sub>·C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>). Its isomer, fumaric acid, only affords 2:1 cocrystal 11-Aza<sub>2</sub>:Fum (4). All cocrystal formation appears driven by acid-lactam R<sub>2</sub><sup>2</sup>(8) heterosynthons with short O-H...O=C hydrogen bonds [O...O = 2.56 (2) Å], augmented by weaker C=O...H-N contacts. Despite a better packing efficiency, cocrystal 3 is metastable with respect to 2, probably due to a higher conformational energy for the maleic acid molecule in its structure. In each case, the microcrystalline powders from LAG were useful in providing seeding for the single-crystal growth.
Study of Slope Failure due to Rainfall: A Comparison Between Experiment and Simulation (2006)

The green house effect has brought change in climate all over the world. In Japan many slope failures due to rainfall often occur in the rainy season. Therefore, it is necessary to investigate the mechanical behavior of unsaturated soil in order to clarify the slope failure mechanisms due to heavy rainfall. In this paper a soil tank test on sandy soil called Shirasu was carried out to investigate the failure mechanism of an unsaturated slope due to the increase in degree of saturation. The numerical simulations using 2D unsaturated-saturated seepage analysis and slope stability analysis is then performed to compare with the experiment in order to prove the validity of numerical simulations at the model scale. It is found from our research results that the proposed models can be used to simulate the seepage behavior of unsaturated Shirasu and to estimate the change in safety factor of the slope with elapsed time due to rainfall.
Functional midbody assembly in the absence of a central spindle (2022)

Contractile ring constriction during cytokinesis is thought to compact central spindle microtubules to form the midbody, an antiparallel microtubule bundle at the intercellular bridge. In Caenorhabditis elegans, central spindle microtubule assembly requires targeting of the CLASP family protein CLS-2 to the kinetochores in metaphase and spindle midzone in anaphase. CLS-2 targeting is mediated by the CENP-F-like HCP-1/2, but their roles in cytokinesis and midbody assembly are not known. We found that although HCP-1 and HCP-2 mostly function cooperatively, HCP-1 plays a more primary role in promoting CLS-2-dependent central spindle microtubule assembly. HCP-1/2 codisrupted embryos did not form central spindles but completed cytokinesis and formed functional midbodies capable of supporting abscission. These central spindle-independent midbodies appeared to form via contractile ring constriction-driven bundling of astral microtubules at the furrow tip. This work suggests that, in the absence of a central spindle, astral microtubules can support midbody assembly and that midbody assembly is more predictive of successful cytokinesis than central spindle assembly.
A 28 Gb/s 560 mW Multi-Standard SerDes With Single-Stage Analog Front-End and 14-Tap Decision Feedback Equalizer in 28 nm CMOS (2014)

This paper presents a 28 Gb/s multistandard SerDes macro which is fabricated in TSMC 28 nm CMOS process. The transimpedance amplifier (TIA) base analog front-end achieved 15 dB high-frequency boost with an on-chip compact passive inductor. The adaptation loop for the boost is decoupled from the decision feedback equalizer (DFE) adaptation by the use of a group delay algorithm. The DFE is a half-rate 1-tap unrolled design with only two total error latches for power and area reduction. A two-stage sense amplifier-based latch achieved sensitivity of 15 mV. The high-speed clock buffer uses a PMOS active inductor circuit with common-mode feedback to optimize the circuit performance. The transceiver achieves error-free operation at 28 Gbps with 34 dB channel loss, consumes the worst case power of 560 mW/lane, and fully complies with multiple standards and applications.
Stabilin-1 mediated monocyte adhesion protects against adverse cardiac inflammation during viral myocarditis (2013)

Purpose: Viral myocarditis is a life-threatening disease characterized by severe cardiac inflammation that can result in sudden death or congestive heart failure in previously healthy adults, and there are no current therapies. Inflammatory cell recruitment is necessary to eliminate the virus but also plays a large role in the pathophysiology therefore understanding the cellular and molecular steps of cardiac inflammation is essential in order to develop new therapies. Methods: In the coxsackie B3 (CVB3) murine model of viral myocarditis, transcript levels of stabilin-1, a transmembranal glycoprotein, increased 3-fold in heart tissue at 9 days post infection. Immunohistochemical detection of stabilin-1 showed an increase of stabilin-1 expression in mouse heart tissue after CVB3 infection and in endomyocardial biopsies from patients with viral myocarditis. Furthermore, stabilin-1 was expressed on mac-3 positive cells in the mouse model and CD68-positve cells in the human biopsies. Stabilin-1 null (KO) mice showed increased cardiac related mortality when challenged with the CVB3 virus in comparison to wild type (WT) mice. Histological analysis of the heart showed that the stabilin-1 KO mice had increased cardiomyocyte necrosis and CD3+ lymphocyte infiltration but lower levels of macrophages cells, in comparison to WT animals. In vitro, Stabilin-1 KO monocytes (cd11b+ cells) had a significant decreased adherence to endothelial cells as compared to WT cells. Fibronectin was identified as the binding partner of stabilin-1, through a 2-yeast hybrid screen and GST-pulldown. Furthermore, Stabilin-1 KO monocytes (cd11b+ cells) had a significant decreased adherence to fibronectin -coated plastic as compared to WT cells. Conclusions: This study shows that the transmembranal glycoprotein Stabilin-1 is up regulated during myocarditis, both in the animal model and in patients with acute fulminant myocarditis. Stabilin-1 is needed for the recruitment of monocytes to the site of infection and interacts with fibronectin in order for monocytes to adhere. These data demonstrate that Stabilin-1 and monocyte recruitment are necessary in order to eliminate the virus and prevent exaggerated inflammation during viral myocarditis.