gebhart/patrepeval huggingface dataset:
Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation (2012)

Glucosamine (GS) is well known for the treatment of inflam-mation. However, the mechanism and efficacy of GS for skin inflammation are unclear. The aim of this study was to evaluate the effects and mechanism of GS in the mouse 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema model. TPA-induced ear edema was evoked in ICR or transglutaminase 2 (Tgase-2) (-/-) mice. GS was administered orally (10-100 mg/kg) or topically (0.5-2.0 w/v %) prior to TPA treatment. Orally administered GS at 10 mg/kg showed a 76 or 57% reduction in ear weight or myeloperoxidase, respectively, and a decreased expression of cyclooxy-genase-2 (COX-2), NF-κB and Tgase-2 in TPA-induced ear edema by western blot and immunohistochemistry. Role of Tgase-2 in TPA ear edema is examined using Tgase-2 (-/-) mice and TPA did not induce COX-2 expression in ear of Tgase-2 (-/-) mice. These observations suggested that Tgase-2 is involved in TPA-induced COX-2 expression in the inflamed ear of mice and anti-inflammatory effects of glucosamine is mediated through suppression of Tgase-2 in TPA ear edema.
Combination of Donepezil and Gabapentin for Behavioral Disorders in Alzheimer's Disease (2000)

Article AbstractLetter to the EditorSir: Behavioral symptoms are very frequent in patients with Alzheimer's disease, and management of these symptoms is a primary goal of therapy. Several drugs may be used with benefit, including atypical neuroleptics, selective serotonin reuptake inhibitors, anticonvulsants, tacrine, and the newer acetylcholinesterase inhibitors such as donepezil, recently indicated for the symptomatic treatment of Alzheimer's disease. Indeed, there are conflicting reports in the literature about the action of donepezil in behavioral disorders associated with Alzheimer's disease, with some authors reporting a benefit and others reporting a worsening of the symptoms.
Electromagnetic modeling as a constituent of multi-disciplined design (2005)

A scalable framework of multi-disciplined design that is able to accommodate any geometric based design discipline is presented. Of the several challenges in the way of high fidelity, physics based design and modeling are the focus of This work. The complexity of a problem described in its raw geometry is overwhelming. The second challenge discussed in This work is the coupling of most, if not all disciplines in an optimization problem when described at the geometric level. Often, the degree of discipline coupling is a function of the type and level of optimization that one is "willing" to pursue, or ignore. Application examples are given in the area of electromagnetic and structural analyses for components appearing in cellular phones.
UV stimulation of DNA-mediated transformation of human cells. (1985)

Irradiation of dominant marker DNA with UV light (150 to 1,000 J/m2) was found to stimulate the transformation of human cells by this marker from two- to more than fourfold. This phenomenon is also displayed by xeroderma pigmentosum cells (complementation groups A and F), which are deficient in the excision repair of UV-induced pyrimidine dimers in the DNA. Also, exposure to UV of the transfected (xeroderma pigmentosum) cells enhanced the transfection efficiency. Removal of the pyrimidine dimers from the DNA by photoreactivating enzyme before transfection completely abolished the stimulatory effect, indicating that dimer lesions are mainly responsible for the observed enhancement. A similar stimulation of the transformation efficiency is exerted by 2-acetoxy-2-acetylaminofluorene modification of the DNA. No stimulation was found after damaging vector DNA by treatment with DNase or gamma rays. These findings suggest that lesions which are targets for the excision repair pathway induce the increase in transformation frequency. The stimulation was found to be independent of sequence homology between the irradiated DNA and the host chromosomal DNA. Therefore, the increase of the transformation frequency is not caused by a mechanism inducing homologous recombination between these two DNAs. UV treatment of DNA before transfection did not have a significant effect on the amount of DNA integrated into the xeroderma pigmentosum genome.
Container Security: Issues, Challenges, and the Road Ahead (2019)

Containers emerged as a lightweight alternative to virtual machines (VMs) that offer better microservice architecture support. The value of the container market is expected to reach $2.7 billion in 2020 as compared to $762 million in 2016. Although they are considered the standardized method for microservices deployment, playing an important role in cloud computing emerging fields such as service meshes, market surveys show that container security is the main concern and adoption barrier for many companies. In this paper, we survey the literature on container security and solutions. We have derived four generalized use cases that should cover security requirements within the host-container threat landscape. The use cases include: (I) protecting a container from applications inside it, (II) inter-container protection, (III) protecting the host from containers, and (IV) protecting containers from a malicious or semi-honest host. We found that the first three use cases utilize a software-based solutions that mainly rely on Linux kernel features (e.g., namespaces, CGroups, capabilities, and seccomp) and Linux security modules (e.g., AppArmor). The last use case relies on hardware-based solutions such as trusted platform modules (TPMs) and trusted platform support (e.g., Intel SGX). We hope that our analysis will help researchers understand container security requirements and obtain a clearer picture of possible vulnerabilities and attacks. Finally, we highlight open research problems and future research directions that may spawn further research in this area.
An ecologically-controlled exoskeleton can improve balance recovery after slippage (2017)

The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human ability to control stability significantly increasing the risk of fall and reducing the overall autonomy. Accordingly, there is an urgent need, from both end-users and society, for novel solutions that can counteract the lack of balance, thus preventing falls among older and fragile citizens. In this study, we show a novel ecological approach relying on a wearable robotic device (the Active Pelvis Orthosis, APO) aimed at facilitating balance recovery after unexpected slippages. Specifically, if the APO detects signs of balance loss, then it supplies counteracting torques at the hips to assist balance recovery. Experimental tests conducted on eight elderly persons and two transfemoral amputees revealed that stability against falls improved due to the "assisting when needed" behavior of the APO. Interestingly, our approach required a very limited personalization for each subject, and this makes it promising for real-life applications. Our findings demonstrate the potential of closed-loop controlled wearable robots to assist elderly and disabled subjects and to improve their quality of life.
Design of Experiments (DoE): a multivariate approach to DSC optimization (2014)

Nowadays, modern science proposed and optimizes new materials and technologies, whose characteristics and performances are governed by many factors. However, the scientific community rarely adopts multivariate strategies for the comprehension of what is proposed. As a striking example, a standard Dye-sensitized Solar Cell (DSC) is a typical complex system assembled with different and heterogeneous layers (FTO/nanocrystalline semiconductor/sensitizer/electrolyte/Pt-FTO), each one affected by intrinsic variability; moreover the layers influence each other and this increases the number of variables involved at the same time in the photoconversion process. Despite the continuous advances of the last years, DSCs are not yet commercialized on large-scale, because they are still subjected to undesirable phenomena, i.e. photodegradation of the dye anchored on semiconductor (especially with metal-free sensitizers), leakage of the electrolyte, diffusion of pollutants from the outside and corrosion of some components. The idea of the present work started from the need to identify all the components by which the photoconversion processes may be influenced. In order to obtain a significant improvement of photovoltaic performances, particularly in reproducibility, long-term stability and efficiency, each stage of the production process of the cell should be investigated. However, this work cannot be conducted with the standard univariate approach, in fact, ranging one variable at a time, it results very difficult to understand and predict the possible synergistic or antagonistic effects (very common in complex systems) due to the interactions between the variables themselves. Therefore, this research was performed with a multivariate approach, exploiting a quantitative chemometric approach (Design of Experiments), because it allows maximizing the information content with the least number of experiments. The encouraging results obtained before in the formulation of novel electrolytes (gel, polymer) and on ZnO-based DSC allowed us to exploit the potentiality of this approach also to the dye loading process and finally to the whole standard TiO2-based DSC. We are firmly convinced that this approach will make possible to find the optimal experimental conditions to achieve, within a good reproducibility, optimized performances, both in term of efficiency and long term stability
Gene targeting in Chinese hamster ovary cells is conservative. (1991)

Two fundamentally different pathways for homologous recombination have been identified in mammalian cells. For most chromosomal recombination events, two copies of a homologous sequence recombine to yield two copies in the products; such events are said to be conservative because the number of copies is preserved. By contrast, virtually all extrachromosomal recombination events are nonconservative; two copies recombine to give a product containing a single intact copy (the other copy is destroyed in the mechanism). Since gene targeting involves an introduced (extrachromosomal) plasmid and a chromosomal target, it was not clear which pathway would apply. We used a marked vector to determine whether targeted integrants were products of recombination events that involved two copies (the conservative pathway) or three copies (the nonconservative pathway) of the homologous sequence. Among 51 gene targeting events, we identified 17 homologous integrants and analyzed their structures. All match the predictions for a conservative pathway. We conclude that the principal pathway for gene targeting in mammalian cells is conservative.
Adapting the Posterior Probability of Diagnosis Index to Enhance Evidence-Based Screening: An Application to ADHD in Primary Care (2020)

This study adapts the Posterior Probability of Diagnosis (PPOD) Index for use with screening data. The original PPOD Index, designed for use in the context of comprehensive diagnostic assessments, is overconfident when applied to screening data. To correct for this overconfidence, we describe a simple method for adjusting the PPOD Index to improve its calibration when used for screening. Specifically, we compare the adjusted PPOD Index to the original index and Naïve Bayes probability estimates on two dimensions of accuracy, discrimination and calibration, using a clinical sample of children and adolescents (N = 321) whose caregivers completed the Vanderbilt Assessment Scale to screen for Attention-Deficit/Hyperactivity Disorder (ADHD) and who subsequently completed a comprehensive diagnostic assessment. Results indicated that the adjusted PPOD Index, original PPOD Index, and Naïve Bayes probability estimates are comparable using traditional measures of accuracy (sensitivity, specificity, AUC) but the adjusted PPOD Index showed superior calibration. We discuss the importance of calibration for screening and diagnostic support tools when applied to individual patients.
Residues of six novel insecticides in unpolished rice and soil by high-performance liquid chromatography method (2013)

A high-performance liquid chromatography(HPLC) method was developed for the determination of flonicamid,chlorantraniliprole,methoxyfenozide,flubendiamide,chlorfenapyr and lufenuron in unpolished rice and soil.The residues were extracted with acetonitrile,and cleaned up with NH2 solid-phase extraction for unpolished rice samples(no cleanup for soil).Determination of analytes was completed using HPLC with DAD detection at 265,254 and 230 nm.The results showed that the coefficient of determination(R2) of this method was above 0.999 4 and the calibration curve was linear in the range of 0.05-5 mg/L.The fortified recoveries of these six pesticides in rice and soil samples at three levels(0.1,0.5,1 mg/kg) were in range of 84.5%-113.2%,with relative standard deviations(RSDs) less than 9.3%.The limit of detection(LOD) of the method was estimated to be 0.010-0.016mg/kg,and the limit of quantification was 0.03-0.05 mg/kg in these samples.
Creation of an Electronic Chronicle for a Ubiquitous Home: Sensing, Analysis and Evaluation (2006)

A system for continuous capture and retrieval of multimedia data from a home-like ubiquitous environment is presented. A large number of cameras and microphones are used for video and audio acquisition. Pressure based sensors mounted on the house floor are used to capture footsteps as context data. Both context and content are analyzed to create indices for efficient retrieval and summarization of the video and audio data. The system can be queried based on date and time, location, persons, sounds and basic activity in terms of footsteps. Key frame extraction adaptive to the activity of a person can be used to summarize the video. The system was evaluated by means of a real-life experiment where a family lived in the house and later used the system to retrieve experiences that they had during their stay. The results of this experiment are reported and discussed. The paper concludes with suggestions for possible future directions.
Magnetic-field-induced Actuation of Ni-Mn- Ga Micropillars (2019)

Preprint of the article:<br> D. Musiienko, L. Straka, L. Klimša, A. Saren, A. Sozinov O.<br> Heczko, K. Ullakko, Magnetic-field-induced Actuation of Ni-Mn-<br> Ga Micropillars, Actuator 18, Conference proceedings, ISBN 978-<br> 3-933339-30-0 MESSE BREMEN (2018) 229.<br> Presented at<br> 16th International Conference on New Actuators<br> 25 – 27 June 2018<br> Bremen, Germany<br> www.actuator.de<br> Preprint made available with the kind permission from the publisher.
Ultrasonic Radiation from an Ideal Piston Source (1949)

The Rayleigh formula for acoustic radiation from an ideal piston source reduces, under suitable approximation given below, to the ordinary Fresnel integral for diffraction through a circular opening. The Fresnel integral is usually expressed in a series of Bessel functions (Lommel function of two arguments) and reduces in the region of validity, to the correct solution along the axis, to the Fraunhofer solution at large distances, and agrees with R. B. Lindsay's solution on a cylinder based on the piston and coaxial with it. In this expansion, the first term represents the Fraunhofer solution but all the terms of the series must be included to give the solution along the axis. An alternative expansion can be given in which the first term represents both the Fraunhofer solution at large distances and the solution along the axis. This expansion is much easier to handle for regions near the axis than the first. For a piston of radius a, these expansions are valid for points at a distance d from the center of the piston within a cone of half-angle θ coaxial with the piston such that (a/d) sin2θ≪λ/a, where λ is the wave-length, and where (a/z)2≪1, z being the distance along the axis from the center of the piston.
Atmospheric pressure monitoring of trace gases using tunable diode lasers (1982)

High-sensitivity measurements of infrared absorptions due to isolated lines broadened by air at atmospheric pressure are reported. Tunable diode lasers and harmonic techniques were employed to detect absorptions as small as 0.01% over path lengths up to 250 m through the open air. The limiting noise source is caused by a base line signal which varies with the optical alignment. The reported sensitivity is not a fundamental limit. Techniques for further increasing sensitivity are discussed.
Preparations of regioselectively methylated cellulose acetates and their 1H and 13C NMR spectroscopic analyses (2002)

Abstract Seven possible regioselectively methylated cellulose acetates (RS‐MCAs)—2,3,6‐tri‐ O ‐methyl cellulose acetate, 3,6‐di‐ O ‐methyl cellulose acetate, 2,6‐di‐ O ‐methyl cellulose acetate, 2,3‐di‐ O ‐methyl cellulose acetate, 6‐ O ‐methyl cellulose acetate, 3‐ O ‐methyl cellulose acetate, and 2‐ O ‐methyl cellulose acetate—were prepared for the first time from chemically synthesized cellulose derivatives obtained by cationic ring‐opening polymerization and then were analyzed by 1 H and 13 C NMR spectroscopy. The chemical shifts of ring protons and carbons were influenced by substituent groups (methyl or acetyl) and clearly reflected the pattern of substituent distribution in anhydroglucose units. These data may conveniently be used for the determination of the substituent distribution of methyl cellulose. The synthesized RS‐MCAs also may be used for the elucidation of the structure–property relationship. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 4167–4179, 2002
Antibody Dependent Cell Mediated Cytotoxicity and Phagocytosis of Senescent Erythrocytes by Autologous Peripheral Blood Mononuclear Cells (2002)

Human red blood cells (RBCs) have a life span of 120 days in circulation, after which they are removed primarily by resident macrophages. Autoimmune antibodies are commonly found on effete RBCs and appear to contribute to their removal from the circulation. In this article, we focused on senescent erythrocytes and studied their removal, in comparison to young RBCs, in two RBC-depletion in vitro assays: antibody dependent cell mediated cytotoxicity (ADCC) and erythrophagocytosis. The results were determined prior to and following the addition of anti-D antibodies to the systems. Old (O-RBC) and young (Y-RBC) erythrocytes were separated by differential centrifugation. When incubated with autologous peripheral blood mononuclear cells as attacking cells, both anti-D treated O-RBCs and anti-D treated Y-RBCs were phagocytized and underwent contact lysis. However, O-RBCs had a significantly higher tendency to be phagocytized (p = 0.05) and a higher predisposition to undergo lysis (p = 0.043) than did Y-RBCs. When incubated with attacking cells without anti-D antibodies, O-RBCs were phagocytized while Y-RBCs were not phagocytized at all (p = 0.046). No contact lysis of either source of target cells occurred when incubated with attacking cells alone without anti-D sera. These in vitro results suggest that ADCC may serve as an additional pathway of elimination of senescent erythrocyte in addition to the classical phagocytosis pathway.
Tratamientos psicológicos y farmacológicos de la fobia social en Europa: un estudio meta-analítico (2002)

Mass spectrometry imaging (MSI) has become a mature, widespread analytical technique to perform non-targeted spatial metabolomics. However, the compounds used to promote desorption and ionization of the analyte during acquisition cause spectral interferences in the low mass range that hinder downstream data processing in metabolomics applications. Thus, it is advisable to annotate and remove matrix-related peaks to reduce the number of redundant and non-biologically-relevant variables in the dataset. We have developed rMSIcleanup, an open-source R package to annotate and remove signals from the matrix, according to the matrix chemical composition and the spatial distribution of its ions. To validate the annotation method, rMSIcleanup was challenged with several images acquired using silver-assisted laser desorption ionization MSI (AgLDI MSI). The algorithm was able to correctly classify m/z signals related to silver clusters. Visual exploration of the data using Principal Component Analysis (PCA) demonstrated that annotation and removal of matrix-related signals improved spectral data post-processing. The results highlight the need for including matrix-related peak annotation tools such as rMSIcleanup in MSI workflows.
Identification of acoustical noise source for electric power steering motor using finite element method (2015)

Recently, electric power steering (EPS) systems have attracted much attention due to their advantages such as high fuel efficiency, tunability of steering feel, weight reduction of steering system, environmental friendliness, etc. [1-4]. However, vibroacoustic radiation noise occurs, which is not seen in hydraulic steering systems. The fundamental source of the vibroacoustic noise is considered to be from the electric motor.
108P Wpływ transferu genów glikozylotransferazy na immunogeniczność czerniaka złośliwehgo u myszy (1998)

Glikozylotransferazy są swoistymi enzymami, biorącymi udział w glikozylacji białek wydzielniczych i powierzchniowych komórki. Ich niedobór lub brak wpływa na strukturę powierzchniowych antygenów i immunogenność komórki. Udoskonalenie metod transferu genów i uzyskiwania ich właściwej ekspresji umożliwiło wprowadzenie genów glikozylotransferaz do komórki. Komórki nowotworowe, pomimo ekspresji na swej powierzchni antygenów rozpoznawanych jako obce, nie ulegają eliminacji. Uważa się, że obniżona immunogenność transfoemowanych komórek wpływa na rozwój choroby nowotworowej. Określenie kinetyki wzrostu guza i czasu przeżycia myszy C57CL6/C3H, którym podskórnie podano komórki mysiego czerniaka (B78-H1) modyfikowane poprzez wprowadzenie genu (β1,4 galctosylotransferazy. Komórki słabo immunogennej linii mysiego czerniaka (B78-H1) transdukowano β1,4 galctosylotransferazą przy użyciu wektora retrowirusowego podwójnej kopii (DCCMV- β1.4GT). Poziom ekspresji mRNA dla 1.4 galaktozylotransferazy oceniano, wykorzystując swoiste 1) znakowane sondy cDNA (Northern Blott) oraz 2) primery (RT-PCR).Wyjściowe (B78-H1) i modyfikowane genetycznie (B78-1,4GT) komórki mysiego czerniaka wstrzykiwano s.c. 8 tygodniowym myszom C57BL6/C3H (5×105komórek). Analizowano dynamikę wzrostu guza, zdolność formowania przerzutów oraz czas przeżycia zwierząt. Wszystkie zwierzęta, którym podano wyjściowe komórki B78-H1 (grupa kontrolna) rozwinęły guz po 3 tygodniach. U myszy, którym zaszczepiono komórki B78-1.4GT guzy pojawiły się 2 tygodnie później. Analiza średniego czasu przeżycia zwierząt wykazała, że zwierzęta zaszczepione komórkami B78-1.4GT przeżywały dłużej w porównaniu z grupą kontrolną.
Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression (2004)

Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function.