gebhart/patrepeval huggingface dataset:
Arbete, familjeliv och återhämtning : en explorativ studie om "tredje skiftet" (2019)

Med utgångspunkt i dygnsberättelser undersöker föreliggande studie förutsättningar för återhämtning. Baserat på gruppintervjuer och en dagboksstudie med anställda på ett svenskt försäkringsbolag fokuserar vi relationen och spänningen mellan första (arbete), andra (icke betalt hemarbete) och tredje (planering/organisering av andra skiftet) skiftet. Begränsade möjligheter för intern återhämtning under arbetet kompenserades av de flesta deltagarna med extern återhämtning under arbetsfri tid. Att ha ensamt ansvar för tredje skiftet reducerade emellertid möjligheterna för återhämtning under dagen och veckan. Materialet visade att kvinnor i åldern 30-45 - i större utsträckning än andra - hade huvudansvaret ett komplext tredje skift.
Die Behandlung der Angle Klasse II mit dem Herbstscharnier unter Berücksichtigung der Auswirkungen auf das Kiefergelenk (2001)

Ziel der vorliegenden Arbeit war es, die Behandlung der Klasse-II-Malokklusion mit dem Herbstscharnier unter besonderer Berücksichtigung der posttherapeutischen Kiefergelenksposition darzustellen. Es sollte das Postulat überprüft werden, ob eine erreichte Klasse-I-Okklusion nach einer 6-8-monatigen Behandlung mit dem Herbstscharnier [ 21] wieder dieselbe zentrische Kondylenposition zeigt [ 15, 16, 20], wie sie vor der Behandlung im Kiefergelenk vorgelegen hatte. Eine kernspintomographische Untersuchung an 96 Kiefergelenken, die jeweils vor, unmittelbar nach Einsetzen und bei Abnahme des Herbstscharniers stattfand, belegte eindeutig, dass es keine signifikanten Veränderungen der posttherapeutischen gegenüber der prätherapeutischen Kiefergelenksposition gab. Die Kondylus-Diskus-Fossa-Relation war nach visueller Überprüfung unverändert. Auch die metrischen Werte, die die Breite des anterioren und posterioren Gelenkspaltes betrafen, ließen statistisch keinerlei signifikante Veränderungen erkennen. Eine Falldokumentation zeigt eine Patientin aus der untersuchten Gruppe, die eine 6-monatige Herbstscharnierbehandlung erfahren hat. Das Ergebnis zeigt eine stabile Klasse-I-Okklusion, bei posttherapeutisch wiedererlangter zentrischer Kondylenposition. Die Kondylus-Diskus-Fossa-Relation ist unverändert. Eine 1 1/2 Jahre später erfolgte Überprüfung der Gelenkposition und die Bisssituation belegen die mit der Herbstscharnier-Behandlung erreichte Stabilität. Die vorliegende Arbeit soll der Beweisführung dienen, dass die Behandlung mit dem Herbstscharnier keinen negativen Einfluss auf die Kiefergelenke ausübt.
Road-to-vehicle communication using LED traffic light (2005)

We propose a parallel wireless optical communication system for road-to-vehicle communication, which uses a LED traffic light as a transmitter and a high-speed camera as a receiver. The newly proposed system which enables multichanneling in LED two dimension arrangement and spatially dividing them. LED transmitters arranged in the shape of a plane are modulated individually, and a camera is used as a receiver for demodulating the signals by using image processing techniques. We performed examination of the transmission speed according to the proposed system in this paper. The actual proof experiment of the proposed system was conducted under the laboratory conditions. We checked that it communicates with a speed of 2.78kbps while 192 LED are spatially divided into eight groups and the high-speed camera set to 500fps.
Quantification of Mechanical Ventricular Dyssynchrony: Direct Comparison of Velocity-Encoded and Cine Magnetic Resonance Imaging (2011)

Measurements of the IVMD by VENC-MRI and the SDt-16 by cine-MRI provide a similar accuracy to identify clinical responders to CRT. However, data analysis of the IVMD is significantly less time-consuming compared to data analysis of the SDt-16.
Scintigraphy and Radiography in Oleic Acid Pulmonary Microvascular Injury (1982)

Using computerized gamma scintigraphy, 10-cm H2O PEEP did not alter the rate of capillary protein leakage in dogs following pulmonary microvascular injury with 0.01 to 0.2 ml/kg oleic acid. A rising lung:heart radioactivity ratio, or 'slope of injury,' was seen during PEEP which paralleled the 'slope of injury' had PEEP not been used. A sudden decrease in lung and heart count activity (p less than 0.001) and decreased lung:heart radioactivity ratio (p less than 0.001) occurred with PEEP at all doses of oleic acid studied. An apparent improvement in the standard chest roentgenogram was seen within 2 minutes following PEEP in dogs given 0.2 ml/kg oleic acid. However, progression of the radiographic infiltrate occurred in these animals during 30 minutes of PEEP. When all vessels leading to and from the heart and lungs were ligated, PEEP produced a 60% fall in count activity over the lung without any change in cardiac radioactivity. The apparent radiographic improvement and 2/3 of the fall in lung radioactivity with PEEP were due to an increased pulmonary air volume and 1/3 due to a decreased pulmonary blood volume. The decreased cardiac output with PEEP must be secondary to decreased ventricular filling rather than decreased ventricular function.
The Effects of Low-Dose Growth Hormone in HIV-Infected Men with Fat Accumulation: A Pilot Study (2004)

Pharmacologic doses of growth hormone (GH) reduce HIV-associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity. Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.
The Role of Extracellular Matrix Quality in Pulmonary Fibrosis (2014)

This review discusses the role of extracellular matrix (ECM) quality in the pathogenesis of pulmonary fibrosis (PF). In PF, the highly ordered structure of collagens and elastin within the ECM of the lung is severely disrupted and lacks its original tissue quality. Discussions about the ECM have focused on the role of protein quantity in relation to the progression of PF, while the importance of lung ECM quality, defined by the levels of ECM protein modifications and by the protein distribution in lung tissue, has not been properly addressed. The quality and function of proteins may be altered by different post-translational modifications (PTMs), such as cross-linking, proteolytic cleavage, citrullination, misfolding and glycosylation. This paper is the first to review key data from the literature related to the lung ECM at the molecular level, relate these to changes observed at a macroscopic level and evaluate which PTMs most likely contribute to PF. This paper also reviews the role of novel neo-epitope-specific biomarkers in the early diagnosis and prognosis of fibrotic disorders. We discuss and argue that the altered quality of the individual ECM proteins contributes to the progression of PF and may also lead to the increased quantity of lung proteins. Thus, both quantity and quality appear to be of utmost importance.
Self-tuning control algorithm design for vehicle adaptive cruise control system through real-time estimation of vehicle parameters and road grade (2016)

The main purpose of this paper is to design a self-tuning control algorithm for an adaptive cruise control (ACC) system that can adapt its behaviour to variations of vehicle dynamics and uncertain road grade. To this aim, short-time linear quadratic form (STLQF) estimation technique is developed so as to track simultaneously the trend of the time-varying parameters of vehicle longitudinal dynamics with a small delay. These parameters are vehicle mass, road grade and aerodynamic drag-area coefficient. Next, the values of estimated parameters are used to tune the throttle and brake control inputs and to regulate the throttle/brake switching logic that governs the throttle and brake switching. The performance of the designed STLQF-based self-tuning control (STLQF-STC) algorithm for ACC system is compared with the conventional method based on fixed control structure regarding the speed/distance tracking control modes. Simulation results show that the proposed control algorithm improves the performance of throttle and brake controllers, providing more comfort while travelling, enhancing driving safety and giving a satisfactory performance in the presence of different payloads and road grade variations.
Molecular characterization of HERV-H variants associated with multiple sclerosis (2000)

Our objective was to characterize retroviral sequences by RT-PCR with gag and env primers on RNA from RT-positive retroviral particles produced by multiple sclerosis (MS) derived B-lymphoblastoid cell lines. Sequence variants with high homology to the potentially functional subgroup RGH of the human endogenous retrovirus RTVL-H/HERV-H family were found. The same sequences were also specifically found in the particulate fraction of a series of MS patient plasma samples and were absent in controls. South-Western blots demonstrate the presence of a nucleic acid binding protein, corresponding in size and function to the nucleocapsid protein, Gag NC, of other retroviruses. We also present indications for transmission of the retrovirus to PHA-stimulated lymphocytes from healthy individuals.
Observation of absorbed NO in the gas–solid reaction process between NO and LaBaSrCu2O6-δ (1998)

The absorption of NO onto LaBaSrCu2O6-δ is investigated by electron energy-loss spectroscopy and X-ray photoelectron spectroscopy. The results suggest that electron transfer from Cu–O planes to absorbed NO takes place and indicate the formation of chemisorbed states of NO- on the oxide surface. It is shown that the NO adsorption into the layered cuprate is related to the charge-transfer type electron structure of the cuprates. Also, it is considered that formation of the NO2- group corresponding to adsorbed NO- trapped by oxygen vacancies on the surface, and subsequent solution of N+ ions play an important role in the gas–solid reaction between NO and double-layer cuprates.
Nucleic‐Acid Analogs with Restricted Conformational Flexibility in the Sugar‐Phosphate Backbone (‘Bicyclo‐DNA’). Part 6. Probing the influence of torsion angle γ on DNA‐duplex stability: Syntheis and properties of oligodeoxynucleotides containing [(3′S,5′S)‐2′‐deoxy‐3′,5′‐ethano‐β‐D‐ribofuranosyl]adenine and ‐thymine (‘5′‐epi‐bicyclodeoxynucleosides’) (1996)

Abstract The synthesis of the thymine‐ and adenine‐containing 5′‐epi‐bicyclodeoxynucleosides 7 and 8 as well as of the corresponding building blocks 13 and 14 for oligonucleotide syntheis according to the phosphoramidite methodology is described. A conformational analysis of 7 and 8 by 1 H‐NMR spectroscopy, refined by molecular modeling, shows the preferred conformation of the furanose unit in these nucleosides to be of the 1′‐ exo /2′‐ endo type. The 5′‐OH group on the carbocyclic ring prefers to be axially oriented, thus placing torsion angle γ in the unusual – syn ‐clinal (– sc ) range. These epi‐bicyclodeoxynucleosides were successfully incorporated into DNA decamers. From UV/melting curves of such decamers with DNA and RNA complements, a duplex destabilization of −2 to −9° per residue was observed. An oligonucleotide built completely from 5′‐epi‐bicyclothymidine shows no detectable affinity to its DNA or RNA complement anymore. CD Spectra of duplexes containing 5′‐epi‐bicyclodeoxynucleotide units are very similar to the natural reference systems, indicating no major structural changes. A molecular‐dynamics simulation of a heptamer duplex containing one 5′‐epibicyclothymidine residue in the center reveals a conformational change of its carbocyclic unit placing torsion angle γ in the (for the free mononucleoside unfavorable) – anti ‐clinal (– ac ) conformation in the duplex. The role of torsion angle γ on DNA duplex stability is discussed.
Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV‐Uninfected female subjects (2014)

This study evaluated the potential for a drug-drug interaction between HCV direct-acting antivirals sofosbuvir or ledipasvir and oral hormonal contraceptive (OC) norgestimate/ethinyl estradiol (norgestimate 0.18/0.215/0.25 mg with ethinyl estradiol 25 μg). This was a 112-day, open-label, fixed-sequence pharmacokinetic (PK) study in healthy female subjects that included a lead-in cycle (OC only; N = 21), cycle 1 (OC only; N = 15), cycle 2 (OC + sofosbuvir; N = 15), and cycle 3 (OC + ledipasvir; N = 15). Administration of sofosbuvir with OC did not alter PK of norelgestromin (primary norgestimate metabolite) or ethinyl estradiol. Small increases in norgestrel (secondary norgestimate metabolite) AUC(tau) (19%) and C(tau) (23%) with sofosbuvir were noted. Ledipasvir did not impact PK of norelgestromin or norgestrel but modestly increased ethinyl estradiol C(max) (40%). Sofosbuvir, GS- 331007 (predominant circulating metabolite of SOF), and ledipasvir PK were similar to historical data. Pharmacodynamic markers luteinizing hormone, follicle-stimulating hormone, and progesterone values were generally comparable in all cycles. No loss in contraceptive efficacy is expected upon administration of sofosbuvir or ledipasvir/sofosbuvir with oral contraceptives containing norgestimate and ethinyl estradiol. The use of sofosbuvir or ledipasvir/sofosbuvir FDC with oral contraceptives is permitted.
Simultaneous Localization, Mapping and Moving Object Tracking (2007)

Simultaneous localization, mapping and moving object tracking (SLAMMOT) involves both simultaneous localization and mapping (SLAM) in dynamic environments and detecting and tracking these dynamic objects. In this paper, a mathematical framework is established to integrate SLAM and moving object tracking. Two solutions are described: SLAM with generalized objects, and SLAM with detection and tracking of moving objects (DATMO). SLAM with generalized objects calculates a joint posterior over all generalized objects and the robot. Such an approach is similar to existing SLAM algorithms, but with additional structure to allow for motion modeling of generalized objects. Unfortunately, it is computationally demanding and generally infeasible. SLAM with DATMO decomposes the estimation problem into two separate estimators. By maintaining separate posteriors for stationary objects and moving objects, the resulting estimation problems are much lower dimensional than SLAM with generalized objects. Both SLAM and moving object tracking from a moving vehicle in crowded urban areas are daunting tasks. Based on the SLAM with DATMO framework, practical algorithms are proposed which deal with issues of perception modeling, data association, and moving object detection. The implementation of SLAM with DATMO was demonstrated using data collected from the CMU Navlab11 vehicle at high speeds in crowded urban environments. Ample experimental results shows the feasibility of the proposed theory and algorithms.
Simultaneous targeting of HCV replication and viral entry by a single gene therapy vector containing multiple RNA interference cassettes: prevention of mutational escape (2005)

Henry, SD1; van der Wegen, PG2; Metselaar, HJ3; Bartenschlager, R4; Tilanus, HW1; Scholte, BJ2; van der Laan, LJW1Author Information
Attempts to control clothes-borne infection in a burn unit: I. Experimental investigations of some clothes for barrier nursing (1977)

Clothes-borne transmission is an important way of spread of infection from patient to patient which is not interrupted by common cotton gowns. New barrier garments were designed from spun-bonded olefin that, in particle penetration tests, was 100 times better as a filter than cotton cloth. Three designs, a gown, a loose coverall and a close overall, were compared with each other and with conventional cotton gowns in experimental exercise and nursing procedures. Staphylococcus aureus from burned patients were used as markers. The close coverall was 4-7 times better than the loose coverall or gown in preventing the soiling of clothes worn underneath it, but appeared to permit substantially more transfer from garments underneath it to a mock 'patient' and to the air than did the looser garments. A cotton gown reduced the soiling of clothes underneath it by more than 10 times and the contamination of a mock patient by more than 30 times as compared with no barrier garment. The close coverall further diminished the contamination of clothes but not the transfer to the patient. The possible mechanisms for the discrepancy between particle transmission tests annd experimental porcedures are discussed.
Association of Leisure-Time Noise Exposure and Hearing Loss:Asociación entre exposición a ruido durante el tiempo libre e hipoacusia (2001)

The purpose of this study was to investigate the association of noisy leisure activities with hearing loss. Participants (n=3571) were examined in a population-based study of age-related hearing loss conducted in Beaver Dam, Wisconsin. Hearing thresholds were determined by audiometry. Hearing loss was defined as the pure-tone average of the frequencies 500,1,000, 2,000, and 4,000 Hz greater than 25 dB HL in either ear. Information regarding exposure to leisure-time noise was obtained by interview. After adjusting for potential confounders, individuals who engaged in leisure activities with average sound levels greater than 90 dBA were significantly more likely to have a hearing loss than participants who did not engage in noisy leisure activities (OR=1.11, 95 per cent 0=1.01-1.22). Individuals who engaged in woodworking were 30 per cent more likely to have a hearing loss than those who had never done woodworking. There was a 6 per cent increased risk of hearing loss for each 5-year period of participation. Health care professionals should consider counseling their patients who engage in noisy leisure activities about the risk of noise-induced hearing loss.
Alpha-1-adrenergic modulation of K and Cl transport in bovine retinal pigment epithelium. (1992)

Intracellular microelectrode techniques were used to characterize the electrical responses of the bovine retinal pigment epithelium (RPE)-choroid to epinephrine (EP) and several other catecholamines that are putative paracrine signals between the neural retina and the RPE. Nanomolar amounts of EP or norepinephrine (NEP), added to the apical bath, caused a series of conductance and voltage changes, first at the basolateral or choroid-facing membrane and then at the apical or retina-facing membrane. The relative potency of several adrenergic agonists and antagonists indicates that EP modulation of RPE transport begins with the activation of apical alpha-1-adrenergic receptors. The membrane-permeable calcium (Ca2+) buffer, amyl-BAPTA (1,2-bis(o-aminophenoxy)-ethane-N,N,N',N' tetraacetic acid) inhibited the EP-induced voltage and conductance changes by approximately 50-80%, implicating [Ca2+]i as a second messenger. This conclusion is supported by experiments using the Ca2+ ionophore A23187, which mimics the effects of EP. The basolateral membrane voltage response to EP was blocked by lowering cell Cl, by the presence of DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonic acid) in the basal bath, and by current clamping VB to the Cl equilibrium potential. In the latter experiments the EP-induced conductance changes were unaltered, indicating that EP increases basolateral membrane Cl conductance independent of voltage. The EP-induced change in basolateral Cl conductance was followed by a secondary decrease in apical membrane K conductance (approximately 50%) as measured by delta [K]o-induced diffusion potentials. Decreasing apical K from 5 to 2 mM in the presence of EP mimicked the effect of light on RPE apical and basolateral membrane voltage. These results indicate that EP may be an important paracrine signal that provides exquisite control of RPE physiology.
Setting up a platform for plant-based influenza virus vaccine production in South Africa (2012)

We managed, after synthesis of two versions of a single gene, to produce by transient and transgenic expression in plants, two variants of a highly pathogenic avian influenza virus HA protein which could have vaccine potential. This is a proof of principle of the potential of plant-produced influenza vaccines as a feasible pandemic response strategy for South Africa and other developing countries.
<title>Peculiarities of laser-assisted drawing-out processing of optical probes for SNOM</title> (1999)

The new optical scheme is built up and is used on the set-up for laser-assisted drawing-out processing (LADOP) and the technique of LADOP for optical fibers are investigated. The probes for SNOM with sizes of aperture about 100 nm were obtained and tested by SNOM. The kinetic model of LADOP is represented.
Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker (2014)

Intracerebral injection of amyloidogenic α-synuclein (αS) has been shown to induce αS pathology in the CNS of nontransgenic mice and αS transgenic mice, albeit with varying efficiencies. In this study, using wild-type human αS transgenic mice (line M20), we demonstrate that intracerebral injection of recombinant amyloidogenic or soluble αS induces extensive αS intracellular inclusion pathology that is associated with robust gliosis. Near the injection site, a significant portion of αS inclusions are detected in neurons but also in astrocytes and microglia. Aberrant induction of expression of the intermediate filament protein peripherin, which is associated with CNS neuronal injury, was also observed predominantly near the site of injection. In addition, many pSer129 αS-induced inclusions colocalize with the low-molecular-mass neurofilament subunit (NFL) or peripherin staining. αS inclusion pathology was also induced in brain regions distal from the injection site, predominantly in neurons. Unexpectedly, we also find prominent p62-immunoreactive, αS-, NFL-, and peripherin-negative inclusions. These findings provide evidence that exogenous αS challenge induces αS pathology but also results in the following: (1) a broader disruption of proteostasis; (2) glial activation; and (3) a marker of a neuronal injury response. Such data suggest that induction of αS pathology after exogenous seeding may involve multiple interdependent mechanisms.
Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7 (2018)

The innate immune system senses influenza A virus (IAV) through different pathogen-recognition receptors (PRR) including Toll-like receptor 7 (TLR7). Downstream of viral recognition natural killer (NK) cells are activated as part of the anti-IAV immune response. Despite the known decisive role of TLR7 for NK cell activation by therapeutic immuno-stimulatory RNAs, the contribution of TLR7 to the NK cell response following IAV infection has not been addressed. We have analyzed lung cytokine responses as well as the activation, interferon (IFN)-γ production and cytotoxicity of lung and splenic NK cells following sublethal respiratory IAV infection in wild-type (WT) and TLR7ko mice. Early airway IFN-γ levels as well as the induction of lung NK cell CD69 expression and IFN-γ production in response to IAV infection were significantly attenuated in TLR7-deficient hosts. Strikingly, respiratory IAV infection also primed splenic NK cells for IFN-γ production, degranulation and target cell lysis, all of which were fully dependent on TLR7. At the same time, lung type I IFN levels were significantly reduced in TLR7ko mice early following IAV infection, displaying a potential upstream mechanism of the attenuated NK cell activation observed. Taken together, our data clearly demonstrate a specific role for TLR7-signalling in local and systemic NK cell activation following respiratory IAV infection despite the presence of redundant innate IAV-recognition pathways.