gebhart/patrepeval huggingface dataset:
Perspective on topological states of non-Hermitian lattices (2019)

Abstract The search of topological states in non-Hermitian systems has gained a strong momentum over the last two years climbing to the level of an emergent research front. In this perspective we give an overview with a focus on connecting this topic to others like Floquet systems. Furthermore, using a simple scattering picture we discuss an interpretation of concepts like the Hamiltonian’s defectiveness, i.e. the lack of a full basis of eigenstates, crucial in many discussions of topological phases of non-Hermitian Hamiltonians.
Prevention of Bone Loss with Alendronate in Postmenopausal Women under 60 Years of Age (1998)

Alendronate prevents bone loss in postmenopausal women under 60 years of age to nearly the same extent as estrogen-progestin.
Joint Placement and Routing of Network Function Chains in Data Centers (2018)

In this work, we investigate the problem of joint optimization over placement and routing of network function chains in data centers. In the offline case, we demonstrate that a classical randomization algorithm works well and we derive a new bound on the performance sub-optimality gap. In the online case, we prove a fundamental lower bound in resource violation and propose a new algorithm that combines techniques from multiplicative weight update and primal-dual update paradigms. This online algorithm asymptotically achieves the best possible performance in terms of resource allocation among all online algorithms. We demonstrate the applicability of our solutions to address practical problems by conducting simulation-based evaluations over different data center architectures using data generated from real trace distribution.
Preparation and Biological Properties of Monoclonal Antibodies Against Human Erythropoietin (1993)

Several monoclonal antibodies (Mabs) against human erythropoietin (H-EPO) were obtained by fusion of myeloma cells with splenocytes from mice immunized with purified recombinant H-EPO. Three Mabs (D7, E14 and E73) were selected by radioimmunoprecipitation on the basis of their high affinity against H-EPO. Their dissociation constants were 0.3 nM for E14 and D7, and 17 nM for E73. The immunochemical properties of these Mabs were analyzed in respect to their capacity to react, to purify, and to inhibit the biological activities of H-EPO. a) detection by Western blotting techniques: among the 3 Mabs only D7 was effective by this technique. b) purification: the best results were observed with E14, an approximately 200-fold purification of H-EPO from culture supernatants was obtained in a single immunopurification step. c) inhibition of the biological activity: the specific binding of 125I-labelled H-EPO to its cellular receptor was inhibited by E14 and E73 but not by D7. These three Mabs exhibited similar effects as far as the inhibition of the proliferation of H-EPO dependent cells (measured by 3H-thymidine incorporation) was concerned.
Alternative Splicing Regulation During Light-Induced Germination of Arabidopsis thaliana Seeds (2019)

Seed dormancy and germination are relevant processes for a successful seedling establishment in the field. Light is one of the most important environmental factors involved in the relief of dormancy to promote seed germination. In <i>Arabidopsis thaliana</i> seeds, phytochrome photoreceptors tightly regulate gene expression at different levels. The contribution of alternative splicing (AS) regulation in the photocontrol of seed germination is still unknown. The aim of this work is to study gene expression modulated by light during germination of <i>A. thaliana</i> seeds, with focus on AS changes. Hence, we evaluated transcriptome-wide changes in stratified seeds irradiated with a pulse of red (Rp) or far-red (FRp) by RNA sequencing (RNA-seq). Our results show that the Rp changes the expression of ∼20% of the transcriptome and modifies the AS pattern of 226 genes associated with mRNA processing, RNA splicing, and mRNA metabolic processes. We further confirmed these effects for some of the affected AS events. Interestingly, the reverse transcriptase-polymerase chain reaction (RT-PCR) analyses show that the Rp modulates the AS of splicing-related factors (<i>At-SR30</i>, <i>At-RS31a</i>, <i>At-RS31</i>, and <i>At-U2AF65A</i>), a light-signaling component (<i>At-PIF6</i>), and a dormancy-related gene (<i>At-DRM1</i>). Furthermore, while the phytochrome B (phyB) is responsible for the AS pattern changes of <i>At-U2AF65A</i> and <i>At-PIF6</i>, the regulation of the other AS events is independent of this photoreceptor. We conclude that (i) Rp triggers AS changes in some splicing factors, light-signaling components, and dormancy/germination regulators; (ii) phyB modulates only some of these AS events; and (iii) AS events are regulated by R and FR light, but this regulation is not directly associated with the intensity of germination response. These data will help in boosting research in the splicing field and our understanding about the role of this mechanism during the photocontrol of seed germination.
Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative (1991)

Recombinant human epidermal growth factor (EGF, 2-10 ng/ml) stimulated growth and production of non-collagenous proteins, but inhibited production of collagen by 60% in cultured human skin fibroblasts. Type analysis of the collagen produced indicated that inhibition of the collagen production observed was mainly a reflection of a reduction in type I collagen. The accumulation of pro alpha 1(I) and pro alpha 2(I) mRNAs and the transcriptional activity of these genes were determined in human skin fibroblasts in order to investigate site(s) of regulation of type I collagen production by human EGF in the absence and presence of L-ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative. Human EGF (10 ng/ml) used alone reduced the steady state levels of mRNAs for pro alpha 1(I) and pro alpha 2(I) chains and transcriptional activity of these genes in vitro by 45%. Asc 2-P (0.2 mM) alone, on the other hand, raised production of type I collagen and the steady state levels of mRNAs for pro alpha 1(I) and pro alpha 2(I) collagen chains as well as stimulated transcriptional activity of these genes. Human EGF attenuated these stimulative effects of Asc 2-P. These results indicate that human EGF regulates type I collagen synthesis at the transcriptional level in cultured fibroblasts in the presence and absence of Asc 2-P. The possibility that human EGF plays a role as a regulator of type I collagen genes in vivo was discussed.
Multifocal intraocular lens to correct presbyopia (2016)

Due to the loss of the flexibility of the crystalline lens, presbyopia is the most common vision dysfunction for adults after 40. To correct presbyopia, this paper presents a design of a MIOL, which can give extended clear vision range both in photopic vision(3mm pupil diameter) and in the mesopic vision(4.5mm pupil diameter). With a pseudophakic eye model, a multi-configuration with object distance covering a full range of normal visual from 8m to 0.4m was applied. The surfaces of MIOL were aspherical diffractive surface. MIOL was divided into two regions: the inner zone was optimized when the pupil diameter was 3mm and the outer zone was optimized when the pupil diameter was 4.5mm. Finally, we got a 22 diopters (D) MIOL with a central thickness of 0.652mm and an optical diameter of 4.5mm. By evaluating the modulation transfer function, we got optical performance of the pseudophakic eye with this MIOL. When the pupil diameter of pseudophakic eye was 3mm, MTF at 50c/mm and 100c/mm was respectively above 0.4 and 0.15 for the object distance from 8m to 0.4m. When the pupil diameter of pseudophakic eye was 4.5mm, MTF at 50c/mm and 100c/mm was respectively above 0.25 and 0.09 for the object distance from 8m to 0.4m.The visual acuity was above 0.9 for the whole visual range at both of two pupil diameters. Therefore it is safe to say that the new MIOL design provides good optical performance for whole visual range under both of the photopic vision and the mesopic vision.
A finite element beam propagation method for strongly guiding and longitudinally varying optical waveguides (1996)

A unified finite element beam propagation method is described for both TE and TM waves propagating in strongly guiding and longitudinally varying optical waveguides with magnetooptic materials. In order to avoid nonphysical reflections from the computational window edges, the transparent boundary condition is introduced for both polarizations. In order to show the validity and usefulness of this approach, numerical examples are presented for a directional coupler composed of two parallel identical waveguides, an S-bend, a Y-branching optical isolator, and a 4-ports optical circulator. The present algorithm is, to our knowledge, the first beam propagation method for modeling nonreciprocal magnetooptic components.
CUP: Controlled Update Propagation in Peer-to-Peer Networks (2002)

Recently the problem of indexing and locating content in peer-to-peer networks has received much attention. Previous work suggests caching index entries at intermediate nodes that lie on the paths taken by search queries, but until now there has been little focus on how to maintain these intermediate caches. This paper proposes CUP, a new comprehensive architecture for Controlled Update Propagation in peer-to-peer networks. CUP asynchronously builds caches of index entries while answering search queries. It then propagates updates of index entries to maintain these caches. Under unfavorable conditions, when compared with standard caching based on expiration times, CUP reduces the average miss latency by as much as a factor of three. Under favorable conditions, CUP can reduce the average miss latency by more than a factor of ten. CUP refreshes intermediate caches, reduces query latency, and reduces network load by coalescing bursts of queries for the same item. CUP controls and confines propagation to updates whose cost is likely to be recovered by subsequent queries. CUP gives peer-to-peer nodes the flexibility to use their own incentive-based policies to determine when to receive and when to propagate updates. Finally, the small propagation overhead incurred by CUP is more than compensated for by its savings in cache misses. 1
Copper Nanoparticles from Copper Aluminum Hydrotalcite: An Efficient Catalyst for Acceptor‐ and Oxidant‐Free Dehydrogenation of Amines and Alcohols (2014)

Abstract An efficient and simple process for the preparation of stable nanocopper(0) on alumina [Cu(0)/Al 2 O 3 ] from the inorganic composite precursor copper aluminum hydrotalcite (Cu‐Al HT) by a chemical reduction method is described. Cu(0)/Al 2 O 3 was employed as an efficient catalyst in the acceptor‐ and oxidant‐free dehydrogenation of various amines and alcohols to their corresponding dehydrogenated products in good to excellent yields. The stability of Cu(0)/Al 2 O 3 was assessed by studying its recoverability and reusability in the dehydrogenation of amines and alcohols for up to five cycles. magnified image
Quantification of Plasma and Urine Thymidine and 2’-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy (2020)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in <i>TYMP</i>, leading to a deficiency in thymidine phosphorylase and a subsequent systemic accumulation of thymidine and 2'-deoxyuridine. Erythrocyte-encapsulated thymidine phosphorylase (EE-TP) is under clinical development as an enzyme replacement therapy for MNGIE. Bioanalytical methods were developed according to regulatory guidelines for the quantification of thymidine and 2'-deoxyuridine in plasma and urine using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for supporting the pharmacodynamic evaluation of EE-TP. Samples were deproteinized with 5% perchloric acid (v/v) and the supernatants analyzed using a Hypercarb column (30 × 2.1 mm, 3 µm), with mobile phases of 0.1% formic acid in methanol and 0.1% formic acid in deionized water. Detection was conducted using an ion-spray interface running in positive mode. Isotopically labelled thymidine and 2'-deoxyuridine were used as internal standards. Calibration curves for both metabolites showed linearity (<i>r</i> > 0.99) in the concentration ranges of 10-10,000 ng/mL for plasma, and 1-50 µg/mL for urine, with method analytical performances within the acceptable criteria for quality control samples. The plasma method was successfully applied to the diagnosis of two patients with MNGIE and the quantification of plasma metabolites in three patients treated with EE-TP.
Solitons and Shock Waves in Two-Electron-Temperature Plasmas (1985)

A modified Korteweg-de Vries equation with nonlocal term due to the Landau damping effect is shown to govern a nonlinear ion acoustic wave even with relatively large amplitude in a two-electron-temperature plasma where uniform states are characterized with the parameters near the boundary between the normal and the anomalous propagation property region.
An Interactive Map of Semantic Web Ontology Usage (2008)

Publishing information on the Semantic Web using common formats enables data to be linked together, integrated and reused. In order to fully leverage the potential for interlinking data by reusing existing schemas, an intuitive way of viewing current usage of RDF vocabularies is required. We present a system which allows a user to view the most frequently occurring namespaces and classes in a large Semantic Web dataset, and the main linkage patterns that exist between them. Users can select a namespace of interest in order to examine usage of a particular ontology, and see how it is being combined with other vocabularies.
Determination of postexcitation thresholds for single ultrasound contrast agent microbubbles using double passive cavitation detection (2010)

This work presents experimental responses of single ultrasound contrast agents to short, large amplitude pulses, characterized using double passive cavitation detection. In this technique, two matched, focused receive transducers were aligned orthogonally to capture the acoustic response of a microbubble from within the overlapping confocal region. The microbubbles were categorized according to a classification scheme based on the presence or absence of postexcitation signals, which are secondary broadband spikes following the principle oscillatory response of the ultrasound contrast agent and are indicative of the transient collapse of the microbubble. Experiments were conducted varying insonifying frequencies (0.9, 2.8, 4.6, and 7.1 MHz) and peak rarefactional pressures (200 kPa to 6.2 MPa) for two types of contrast agents (Definity and Optison). Results were fit using logistic regression analysis to define pressure thresholds where at least 5% and 50% of the microbubble populations collapsed for each frequency. These thresholds were found to occur at lower pressures for Definity than for Optison over the range of frequencies studied; additionally, the thresholds occurred at lower pressures with lower frequencies for both microbubble types in most cases, though this trend did not follow a mechanical index scaling.
ChemInform Abstract: Influence of the Aqueous Growth Medium on the Growth Rate, Composition, and Structure of Hydrous Iridium Oxide Films. (1988)

Abstract The dissolution of Ir oxide during electrochemical growth is found to be much less in neutral LiClO 4 solutions than in H 2 SO 4 solutions, allowing higher growth rates to be achieved.
Propargyl Radicals in Organic Synthesis (2021)

Abstract The appearance of propargyl radicals as synthetic intermediates has increased in recent years from a structural curiosity to a frequent occurrence. This minireview covers the synthetically relevant organic chemistry involving the intermediacy of propargyl radicals. The review is organized by the process employed in radical generation, including H‐atom abstraction, propargyl‐X homolyses, radical addition to enynes, reduction of polar C=X bonds, reductions of stable carbocations, and metal‐mediated coupling reactions. The relevant mechanisms of generation and reaction are discussed, as are applications in syntheses of target molecules of interest.
Fretting wear of Ti(CxNy) PVD coatings under variable environmental conditions (2006)

Fretting wear as a specific type of degradation is defined as an oscillatory motion at small amplitude between two nominally stationary solid bodies in mutual contact. Under external stresses, the interface is being damaged by debris generation and its successive ejections outside the contact area. A potential protection against fretting damage by means of hard coatings is being offered by different surface engineering techniques. For this study, TiC, TiN, and TiCN hard coatings manufactured by a physical vapour deposition method have been selected and tested against smooth polycrystalline alumina ball. A fretting test programme has been carried out at the frequency of 5 Hz, 100 N normal load, 100 μm displacement amplitude, and at three values of a relative humidity (RH): 10, 50, and 90 per cent at 295-298 K temperature. It turned out that the intensity of wear process was depending not only on loading conditions but also on environmental ones. A significant impact of RH on wear rate and friction behaviour of the coatings under investigation has been observed. Two different damage mechanisms have been identified and related to the phenomena of debris oxidation and debris adhesion to the counterbody surface. In the latter case, the debris deposited onto the surface of the alumina ball lead to a change of stress distribution at the interface and as a result to accelerated wear. In this work, experiments with variable RH increasing from 10 to 90 per cent within a single fretting test have been completed. It follows from these experiments that there exists an intermediate value of the RH at which the friction coefficient changes rapidly. Finally, a dissipated energy approach has been applied in the work to quantify and compare fretting wear rates of different hard coatings.
Workload-Adaptive Configuration Tuning for Hierarchical Cloud Schedulers (2019)

Cluster schedulers provide flexible resource sharing mechanism for best-effort cloud jobs, which occupy a majority in modern datacenters. Properly tuning a scheduler's configurations is the key to these jobs' performance because it decides how to allocate resources among them. Today's cloud scheduling systems usually rely on cluster operators to set the configuration and thus overlook the potential performance improvement through optimally configuring the scheduler according to the heterogeneous and dynamic cloud workloads. In this paper, we introduce AdaptiveConfig, a run-time configurator for cluster schedulers that automatically adapts to the changing workload and resource status in two steps. First, a comparison approach estimates jobs' performances under different configurations and diverse scheduling scenarios. The key idea here is to transform a scheduler's resource allocation mechanism and their variable influence factors (configurations, scheduling constraints, available resources, and workload status) into business rules and facts in a rule engine, thereby reasoning about these correlated factors in job performance comparison. Second, a workload-adaptive optimizer transforms the cluster-level searching of huge configuration space into an equivalent dynamic programming problem that can be efficiently solved at scale. We implement AdaptiveConfig on the popular YARN Capacity and Fair schedulers and demonstrate its effectiveness using real-world Facebook and Google workloads, i.e., successfully finding best configurations for most of scheduling scenarios and considerably reducing latencies by a factor of two with low optimization time.
Triamcinolone Acetonide Inhibits IL-6– and VEGF-Induced Angiogenesis Downstream of the IL-6 and VEGF Receptors (2006)

IL-6- and VEGF-mediated corneal neovascularization are blocked by TA through the mifepristone-sensitive steroid receptor. TA inhibits IL-6-induced STAT3 expression in cornea, but it does not inhibit activation of the IL-6 or the VEGF receptor in cultured human endothelial cells. This finding has two implications. The fact that TA directly inhibits VEGF action implies that other factors may be critical to angiogenesis and sensitive to glucocorticoids.
Impact of embedded Mn nanodots on resistive switching characteristics of Si-rich oxides as measured in Ni-electrode metal–insulator–metal diodes (2016)

Abstract We studied the formation of high-density Mn nanodots (NDs) by remote H 2 plasma (H 2 -RP) treatment and investigated how the embedding of Mn NDs affects the resistive switching properties of Si-rich oxides (SiO x ) because it is expected that NDs will trigger the formation of the conductive filament path in SiO x . We fabricated Mn NDs with different ND areal densities by exposing an ultrathin Mn layer on the SiO x /Ni bottom electrode to H 2 -RP without external heating. After the deposition of SiO x as a resistive switching layer and the fabrication of Ni top electrodes, resistive switching behaviors of metal–insulator–metal (MIM) diodes were characterized from current–voltage ( I – V ) curves and compared with the results obtained from samples of SiO x without Mn NDs and with an ultrathin Mn layer instead. The embedding of Mn NDs in SiO x was found to be effective in increasing the ON/OFF ratio in resistance and reducing the variation in operation voltage.
Home Equity Lending (1989)

Housing - Finance; Home equity loans; Mortgages
Human dynamics revealed through Web analytics (2008)

The increasing ubiquity of Internet access and the frequency with which people interact with it raise the possibility of using the Web to better observe, understand, and monitor several aspects of human social behavior. Web sites with large numbers of frequently returning users are ideal for this task. If these sites belong to companies or universities, their usage patterns can furnish information about the working habits of entire populations. In this work, we analyze the properly anonymized logs detailing the access history to Emory University's Web site. Emory is a medium-sized university located in Atlanta, Georgia. We find interesting structure in the activity patterns of the domain and study in a systematic way the main forces behind the dynamics of the traffic. In particular, we find that linear preferential linking, priority-based queuing, and the decay of interest for the contents of the pages are the essential ingredients to understand the way users navigate the Web.
Bloody Tears of Unknown Cause (2004)

Bloody tearing is an unusual clinical entity that concerns patients and can perplex physicians. A thorough examination and proper workup are necessary to rule out serious conditions but may fail to determine a cause. These idiopathic cases typically resolve without treatment.