gebhart/patrepeval huggingface dataset:
Improved Selectivity in Cylindrical TE/sub 011/ Filters by TE/sub 211/TE/sub 311/ Mode Control (1982)

A new method is presented for the design of low loss cylindrical TE/sub 011/-mode resonators whereby transmission nulls can be placed near the TE/sub 011/, resonance by controlling the TE/sub 211/, and TE/sub 311/, modes that are naturally excited in the same resonator. The frequencies at which the nulls occur are controlled by the angular offset of the sidewall coupling apertures and the relative amplitude of the TE/sub 011/ mode compared to the TE/sub 211/ and TE/sub 311/ modes. It is also shown that a lumped constant circuit model can be used to accurately represent the multimode response of the resonator.
Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. I. Mutations on the third chromosome. (1989)

Fifty-one dominant female sterile (Fs) mutations linked to the third chromosome of Drosophila melanogaster are described. EMS induced Fs mutations arise with the frequency of one Fs per about 2500 recessive lethals. Complementation analysis of the revertants showed that these Fs mutations represent 27-34 loci, about 60% of the third chromosome units mutable to dominant female sterility by EMS. The Fs mutations were mapped on the basis of mitotic recombination induced in the female (in 16 cases also in the male) germ-line. Behavior of the revertants and the Fs+ germ-line clones demonstrate the gain-of-function nature of the Fs alleles. With two exceptions, the Fs(3) mutations are germ-line dependent. Novel phenotypes appeared in most of the Fs mutations. With eight exceptions, the Fs(3) mutations are fully penetrant, in some cases with variable expressivity. One of the Fs(3) mutations is a non-ovary-dependent egg retention mutation, two others alter egg shape, and 27 bring about arrest in development at about the time of fertilization. In 21 of the Fs(3) mutations embryos develop to the larval stage of differentiation; this group includes 5 new alleles of Toll and 4 of easter.
Tracing the origin and evolutionary history of plant nucleotide‐binding site–leucine‐rich repeat (NBS‐LRR) genes (2011)

Plant disease resistance genes (R genes) encode proteins that function to monitor signals indicating pathogenic infection, thus playing a critical role in the plant's defense system. Although many studies have been performed to explore the functional details of these important genes, their origin and evolutionary history remain unclear. In this study, focusing on the largest group of R genes, the nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes, we conducted an extensive genome-wide survey of 38 representative model organisms and obtained insights into the evolutionary stage and timing of NBS-LRR genes. Our data show that the two major domains, NBS and LRR, existed before the split of prokaryotes and eukaryotes but their fusion was observed only in land plant lineages. The Toll/interleukin-1 receptor (TIR) class of NBS-LRR genes probably had an earlier origin than its nonTIR counterpart. The similarities of the innate immune systems of plants and animals are likely to have been shaped by convergent evolution after their independent origins. Our findings start to unravel the evolutionary history of these important genes from the perspective of comparative genomics and also highlight the important role of reorganizing pre-existing building blocks in generating evolutionary novelties.
Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors (2008)

Abstract Histone deacetylase inhibitors (HDACi) have been hailed as a powerful new class of anticancer drugs. The HDACi, trichostatin A (TSA), is thought to interfere with epigenetic control of cell cycle progression in G1 and G2-M phase, resulting in growth arrest, differentiation, or apoptosis. Here, we describe a novel mechanism of action of HDACis in promoting immune responses against tumors. We report that treatment of carcinoma cells with TSA increases the expression of many components of the antigen processing machinery, including TAP-1, TAP-2, LMP-2, and Tapasin. Consistent with this result, we found that treatment of metastatic carcinoma cells with TSA also results in an increase in MHC class I expression on the cell surface that functionally translates into an enhanced susceptibility to killing by antigen-specific CTLs. Finally, we observed that TSA treatment suppresses tumor growth and increases tap-1 promoter activity in TAP-deficient tumor cells in vivo. Intriguingly, this in vivo anti-tumoral effect of TSA is entirely mediated by an increase in immunogenicity of the tumor cells, as it does not occur in immunodeficient mice. These novel insights into the molecular mechanisms controlling tumor immune escape may help revise immunotherapeutic modalities for eradicating cancers. [Cancer Res 2008;68(23):9601–7]
Anti-myelin-associated glycoprotein neuropathy (2006)

Therapy in patients with anti-MAG neuropathy is directed at reducing the antibody concentration, blocking the effector mechanisms and depleting the monoclonal B cells. The recent availability of rituximab, a monoclonal antibody suppressing B-cell clones, which is not myelosuppressive and does not cause secondary malignancies, allows for early targeted intervention.
Developing a Mobile Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events Administration System to Capture Postradiation Toxicity in Oncology: Usability and Feasibility Study (Preprint) (2021)

<sec> <title>BACKGROUND</title> Accurate self-reported symptomatic toxicity documentation via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is essential throughout cancer treatment to ensure safety and understand therapeutic efficacy. However, the capture of accurate toxicities from patients undergoing radiation therapy is challenging because this is generally provided only at the time of scheduled visits. </sec> <sec> <title>OBJECTIVE</title> This study seeks to establish the usability and feasibility of a mobile PRO-CTCAE Administration System (mPROS) to capture toxicities related to radiation therapy. </sec> <sec> <title>METHODS</title> English-speaking adult patients who were undergoing radiation therapy for cancer were enrolled and given a brief demonstration of the Say All Your Symptoms (SAYS) and Symptom Tracking Entry Program (STEP) interfaces of the mPROS app, followed by a patient-use phase where patient actions were observed as they navigated mPROS to enter toxicities. Patient feedback was captured via a semistructured interview and brief questionnaire. </sec> <sec> <title>RESULTS</title> We enrolled 25 patients (age: mean 60.7 years; females: n=13, 52%; White patients: n=13; 52%; non-Hispanic patients: n=19, 76%; college graduates: n=17, 68%). Patients almost equally preferred the SAYS (n=14, 56%) or STEP (n=11, 44%) interfaces, with 21 patients (84%) agreeing that they would use mPROS to report their symptoms to their health care team and 19 patients (76%) agreeing that they would recommend mPROS to others. </sec> <sec> <title>CONCLUSIONS</title> The mPROS app is usable and feasible for facilitating the patient reporting of radiation therapy–related symptomatic toxicities. A revised version of mPROS that incorporates patient input and includes electronic health record integration is being developed and validated as part of a multicenter trial. </sec>
Enhanced Tomographic Sensing Multimodality with a Crystal Analyzer (2020)

This article demonstrates how a combination of well-known tools-a standard 2D detector (CCD (charge-coupled device) camera) and a crystal analyzer-can improve the multimodality of X-ray imaging and tomographic sensing. The use of a crystal analyzer allowed two characteristic lines of the molybdenum anode-Kα and Kβ-to be separated from the polychromatic radiation of the conventional X-ray tube. Thus, as a result of one measurement, three radiographic projections (images) were simultaneously recorded. The projection images at different wavelengths were separated in space and registered independently for further processing, which is of interest for the spectral tomography method. A projective transformation to compensate for the geometric distortions that occur during asymmetric diffraction was used. The first experimental results presented here appear promising.
Ion energy distribution from colliding laser plasmas (2019)

Abstract We report the development of an electrostatic sector analyser (ESA) combined with a time-of-flight (TOF) spectrometer along with some preliminary results from its use in measuring the energies of ions emitted from colliding laser produced plasmas.
Supplementary Figures 1 - 3 from Predicting Response to Bevacizumab in Ovarian Cancer: A Panel of Potential Biomarkers Informing Treatment Selection (2023)

&lt;p&gt;PDF file - 269K, Supplementary Figure 1: Differences in AGP, mesothelin and FLT4 concentrations between responders and non responders in the discovery sample set (n=10); Supplementary Figure 2: Progression-free survival in validation cohort I; Supplementary Figure 3: Baseline concentrations of mesothelin, FLT4, AGP and CA125 in: a). validation cohort I, b). validation cohort II, and c). both validation cohorts combined.&lt;/p&gt;
Near-room temperature relaxor multiferroic (2010)

We report the fabrication and characterization of highly oriented Pb(Zr0.53Ti0.47)0.60(Fe0.5Ta0.5)0.40O3 thin films. Dielectric spectra showed a maximum (Tm) around 350 K for 1 kHz that shifted to higher temperatures (by ∼30 K) with an increase in frequency up to 1 MHz. High dielectric dispersion below and above Tm, low dielectric loss (2%–5%), high dielectric constant (∼1380@1 kHz), ferroelectric polarization, and weak magnetic moment are observed. Real and imaginary dielectric data were fitted with a nonlinear Vogel–Fulcher equation, implying a relaxor nature. The ac conductivity shows frequency-dependent conductivity, low loss, and frequency-dependent kinks near Tm.
Electro-acupuncture for central obesity: randomized, patient-assessor blinded, sham-controlled clinical trial protocol (2021)

ClinicalTrials.gov Identifier: NCT03815253 ,Registered 24 Jan 2019.
The chromatin structure of centromeres from fission yeast: differentiation of the central core that correlates with function. (1991)

We have examined the chromatin structure of centromere regions from the fission yeast Schizosaccharomyces pombe. The large and complex centromere regions of the S. pombe chromosomes encompass many kilobase pairs of DNA and contain several classes of tandemly repeated DNA sequences. The repeated sequences are further organized into a large inverted repeat flanking a central core, a conserved structural feature among all three centromeres in S. pombe. The nucleosomal configuration of the centromere regions is nonuniform and highly varied. Most of the centromere-specific repeated DNA sequences are packaged into nucleosomes typical of bulk chromatin. However, the central core and core-associated repeated sequences from the centromere regions of chromosomes I (cen1) and II (cen2), when present in S. pombe, show an altered chromatin structure, with little or no evidence of regular nucleosomal packaging. The atypical chromatin organization of the cen2 central core is not due to transcription, as no transcripts from this region were detected. These same DNA sequences, however, are packaged into nucleosomes typical of bulk chromatin when present in a nonfunctional environment on a minichromosome in the budding yeast Saccharomyces cerevisiae. Because the cen2 central core sequences themselves do not preclude regular nucleosomal packaging, we speculate that in S. pombe they constitute a specialized site of kinetochore protein assembly. The atypical nucleosomal pattern of the cen2 central core remains constant during the cell cycle, with only minor differences observed for some sequences. We propose that the unusual chromatin organization of the core region forms the basis of a higher order structural differentiation that distinguishes the centromere from the chromosome arms and specifies the essential structure for centromere function.
ChemInform Abstract: Highly Selective Direct and Indirect Anodic Monofluorination of Heterocyclic Compounds (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Criteria for Chaotic Vibrations (1992)

This chapter contains sections titled: Introduction Empirical Criteria for Chaos Theoretical Predictive Criteria Lyapunov Exponents
The improvement in cryogenic mechanical properties of nano-ZrO2/epoxy composites via surface modification of nano-ZrO2 (2016)

This study investigated the cryogenic mechanical properties of modified nano-ZrO<sub>2</sub> reinforced epoxy composites.
Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding (1998)

The mammalian zona pellucida surrounding ovulated eggs mediates sperm binding at fertilization, provides a postfertilization block to polyspermy, and facilitates passage of pre-implantation embryos down the oviduct. Although the three zona proteins (ZP1, ZP2, ZP3) are well conserved, mammalian fertilization is relatively specific and human sperm do not bind to the mouse zona pellucida. There are considerable in vitro data that ZP3 acts as a primary sperm adhesion molecule in mice and, by analogy, a similar role has been postulated for human ZP3. Genetically altered mice lacking ZP3 (Zp3(tm/tm)) do not form a zona pellucida and are infertile. To rescue this phenotype, transgenic mice expressing human ZP3 (67% identical to mouse ZP3) were produced and bred with Zp3(tm/tm) null mice. The resultant human ZP3 rescue females had chimeric zonae pellucidae composed of mouse ZP1, mouse ZP2 and human ZP3. Human ZP3 expressed in mouse oocytes had an apparent mass (64 kDa) indistinguishable from native human ZP3 and distinct from mouse ZP3 (83 kDa). Despite the presence of human ZP3, human sperm did not bind to the chimeric zona pellucida, and notwithstanding the absence of mouse ZP3, mouse sperm bound to ovulated eggs in vitro and fertility was restored in vivo. These data have implications regarding the molecular basis of mouse and human sperm binding to their respective zonae pellucidae.
Visceral hypersensitivity in irritable bowel syndrome (2011)

Altered central processing, abnormal gastrointestinal motility and visceral hypersensitivity may be possible major pathophysiology of irritable bowel syndrome (IBS). These factors affect each other and are probably associated with development of IBS symptoms. It has been confirmed that lower pain threshold to colonic distention was observed in most of patients with IBS than healthy subjects. We have investigated pain perception of the descending colon among different subtypes of IBS. There was no difference in pain threshold to colonic distention between IBS with diarrhea and constipation. Some brain regions such as the anterior cingulate cortex (ACC) may play a major role for generating pain and/or pain-related emotion in humans. IBS patients showed greater activation in the perigenual ACC during painful rectal distention compared with healthy subjects. Inflammation, stress and the combination of both stimuli can induce significant increase in visceral sensitivity in animal models. Serotonin (5-HT) can modulate visceral perception. It has been thought that 5-HT(3) receptors may play an important role for conveying visceral sensation from the gut. Corticotropin-releasing hormone (CRH) may also modulate visceral pain hypersensitivity in IBS. CRH receptor-1 antagonist significantly prevented an increase in gut sensitivity in rats. It has been demonstrated that non-specific CRH receptor antagonist α-helical CRH significantly reduced abdominal pain score during gut stimulus in patients with IBS. In conclusion, visceral hypersensitivity is common in IBS patients and probably plays a major role in development of the symptoms and both central and peripheral factors may enhance the pain sensitivity.
The Lindlar Catalyst Revitalized: A Highly Chemoselective Method for the Direct Conversion of Azides to N‐(tert‐Butoxycarbonyl)amines. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Implications of the invariant gamma-chain on the intracellular transport of class II histocompatibility antigens. (1985)

Abstract We have examined the role of the invariant gamma-chain on the intracellular transport of human class II histocompatibility antigens. mRNA was selected by hybridization to cDNA corresponding to class II alpha-, beta-, and gamma-chains, and the obtained mRNA fractions were injected individually and in various combinations into X. laevis oocytes. Translation products were isolated after various periods of chase, and their carbohydrate moieties were analyzed to monitor the subcellular localization of polypeptide chains. A mixture of alpha-, beta-, and gamma-chains, or gamma-chains alone, were transported and glycosylated to the same extent as in a B lymphoblastoid cell line. However, although alpha- and beta-chains formed a complex in the absence of the gamma-chain, the transport of this complex was slowed down. Furthermore, the glycosylation of alpha- and beta-chains appeared incomplete. Thus, the invariant gamma-chain seems to play a crucial role for the rate of transport and glycosylation of class II alpha- and beta-chains.
Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles (2015)

Mitral regurgitation (MR) is one of the most prevalent valve disorders and has numerous aetiologies, including primary (organic) MR, due to underlying degenerative/structural mitral valve (MV) pathology, and secondary (functional) MR, which is principally caused by global or regional left ventricular remodelling and/or severe left atrial dilation. Diagnosis and optimal management of MR requires integration of valve disease and heart failure specialists, MV cardiac surgeons, interventional cardiologists with expertise in structural heart disease, and imaging experts. The introduction of transcatheter MV therapies has highlighted the need for a consensus approach to pragmatic clinical trial design and uniform endpoint definitions to evaluate outcomes in patients with MR. The Mitral Valve Academic Research Consortium is a collaboration between leading academic research organizations and physician-scientists specializing in MV disease from the United States and Europe. Three in-person meetings were held in Virginia and New York during which 44 heart failure, valve, and imaging experts, MV surgeons and interventional cardiologists, clinical trial specialists and statisticians, and representatives from the U.S. Food and Drug Administration considered all aspects of MV pathophysiology, prognosis, and therapies, culminating in a 2-part document describing consensus recommendations for clinical trial design (Part 1) and endpoint definitions (Part 2) to guide evaluation of transcatheter and surgical therapies for MR. The adoption of these recommendations will afford robustness and consistency in the comparative effectiveness evaluation of new devices and approaches to treat MR. These principles may be useful for regulatory assessment of new transcatheter MV devices, as well as for monitoring local and regional outcomes to guide quality improvement initiatives.
Supplemental Figure 2 from PARP Inhibitor Activity Correlates with <i>SLFN11</i> Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer (2023)

&lt;p&gt;PARP1 expression does not predict PARP inhibitor sensitivity in SCLC. SLFN11 gene and protein expression correlate.&lt;/p&gt;
An Extended Multiresolution Approach To Mouth Specific Aam Fitting For Speech Recognition (2011)

Publication in the conference proceedings of EUSIPCO, Barcelona, Spain, 2011
A Model for Mother Liquor Recycle in Batch Processing (1997)

A simple model for the continuous recycle of mother liquors from a crystallization or precipitation is discussed. It is shown that the impurity profile of the mother liquors, at moderate recycle levels, quickly reaches a steady state according to (1 − xn+1)/(1 − x), where n is the number of times the process is operated and x is the fraction of mother liquors recycled. Practical applications of the procedure are discussed, and it is shown that a relatively small amount of laboratory work would be required to test a real system under the continuous recycle conditions. An example of the successful application of the procedure to a multitonne per annum manufacturing operation is described.
Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes (2000)

The core protein of hepatitis C virus (HCV) is believed to form the capsid shell of virus particles. Maturation of the protein is achieved through cleavage by host cell proteases to give a product of 21 000 MW, which is found in tissue culture systems and sera from infected individuals. However, efficient propagation of the virus is not possible at present in tissue culture. Hence, studies have focused on the properties of the core protein and its possible role in pathologies associated with HCV infection. This review describes key features of the polypeptide and the status of current knowledge on its ability to influence several cellular processes.
Mid-gap invasion in two-layer slot coating (2009)

Multi-layer, continuous liquid coating is the most efficient way to manufacture films that require more than one layer for optimal performance. Dual-layer slot coating is one of different coating methods largely used to deposit two thin, uniform liquid layers on to a moving substrate. The two liquid phases are separated by an inter-layer that starts at the separation point (or line, in three dimensions) attached to the die surface. The stability of the two-phase flow and the location of the separation point are directly related to the quality of the final product. Ideally, the separation point should be attached to the downstream corner of the mid die piece of a dual slot-coating die. However, its location may change as operating conditions vary, leading to undesired flow states, with microvortices and periodic oscillation. The movement of the separation point from its desired location along the die surface is usually referred to as mid-gap invasion and can be associated with the onset of coating defects. It is crucial to determine the set of flow conditions at which it occurs. We study the evolution of the separation-point location and the inter-layer configuration as a function of operating conditions by flow visualization and by solving the two-dimensional Navier–Stokes equation for free-surface flows. The results reveal two different mechanisms for mid-gap invasion, depending on the viscosity ratio of the two liquid layers. They also show that the most critical parameter responsible for the onset of mid-gap invasion is the bottom-layer wet thickness (flow rate). Although the movement of the separation point involves an evolution of complex flow states, a simple but accurate criterion based on rectilinear flow approximation is proposed.
Spinal Implants: Bioengineering a Multicomponent Spinal Motion Segment Construct—A 3D Model for Complex Tissue Engineering (Adv. Healthcare Mater. 1/2015) (2015)

The first realization of a bioengineered quadri-phasic spinal motion segment (SMS) is reported by B. P. Chan and co-workers on page 99 using mesenchymal stem cells (MSC) and collagen as starting materials. The construct consists of two vertebrae-endplate-like subunits, sandwiching a multi-lamellae annulus fibrosus-like component, which entraps a soft nucleus pulposus-like core. The complex hierarchical organization ranges from nano-fibrous collagen meshwork to micrometer-sized MSC-collagen beads, and from millimeter-sized individual tissue components to centimeter-sized SMS construct.