gebhart/patrepeval huggingface dataset:
Regulation of ATP Citrate-Lyase Gene Expression in Hepatocytes and Adipocytes in Normal and Genetically Obese Rats (1999)

Transcriptional regulation of ATP citrate-lyase (ACL, one of the lipogenic enzymes) gene by glucose/insulin, polyunsaturated fatty acid (PUFA), and leptin has been investigated in hepatocytes and adipocytes of obese Wistar fatty rats and their lean littermates. The sequence spanning nucleotides -64 to -41 of the ACL gene, which is responsive to glucose/insulin stimulation [Eur. J. Biochem. 247, 497-502, 1997], was linked to a reporter gene and transfected into rat hepatocytes or adipocytes. The chloramphenicol acetyltransferase (CAT) activities in the presence of glucose alone were similar in primary cultured cells from both obese and lean rats. In the presence of glucose/insulin, however, the CAT activities were markedly increased in the hepatocytes of lean rats, but were not significantly increased in those of obese rats. The stimulation by glucose/insulin was reduced in PUFA-treated cells of lean rats. The stimulation was also reduced in leptin-treated cells or ob gene expression vector-containing cells. However, PUFA- or leptin-treated cells from obese rats did not show a significant reduction in insulin stimulation. The same effects were observed at the endogenous mRNA and enzyme levels. Similar results were seen in adipocytes, although the stimulation and suppression levels were much smaller than in hepatocytes. The expression of endogenous insulin receptor in hepatocytes and adipocytes was reduced in the presence of leptin or PUFA. We previously found that insulin-binding capacities are also reduced in the presence of leptin or PUFA and are very low in obese rats in comparison with lean. Moreover, gel mobility shift assays using end-labeled ACL(-64/-41) revealed that nuclear factor(s) including Sp1 bind specifically to the sequence, and DNA-protein complex formation is reduced in the obese rats. Thus, the reductions in the insulin-stimulated ACL transcription may be ascribed in part to reductions in insulin binding to receptors and DNA-protein complex formation.
Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy (2012)

Histamine releasing factor (HRF), also known as translationally controlled tumor protein (TCTP), is a highly conserved, ubiquitous protein that has both intracellular and extracellular functions. Here, we will highlight the history of the molecule, its clinical implications with a focus on its extracellular functioning, and its potential role as a therapeutic target in asthma and allergy. The cells and cytokines produced when stimulated or primed by HRF/TCTP are detailed as well as the downstream signaling pathway that HRF/TCTP elicits. While it was originally thought that HRF/TCTP interacted with IgE, the finding that cells not binding IgE also respond to HRF/TCTP called this interaction into question. HRF/TCTP, or at least its mouse counterpart, appears to interact with some, but not all IgE and IgG molecules. HRF/TCTP has been shown to activate multiple human cells including basophils, eosinophils, T cells, and B cells. Since many of the cells activated by HRF/TCTP participate in the allergic response, extracellular functions of HRF/TCTP may exacerbate the allergic, inflammatory cascade. Particularly exciting is that small molecule agonists of Src homology 2-containing inositol phosphatase-1 have been shown to modulate the phosphoinositide 3-kinase/AKT pathway and may control inflammatory disorders. This review discusses this possibility in light of HRF/TCTP.
VAPOR PLATING OF ALUMINUM ON STEEL (1962)

NOTICE: When government or other drawings, speci-fications or other data are used for any purpose other than in connection with a definitely related government procurement operation, the U. S. Government thereby incurs no responsibility, nor any obligation whatsoever; and the fact that the Govern-ment may have formulated, furnished, or in any way supplied the said drawings, specifications, or other data is not to be regarded by implication or other-wise as in any manner licensing the holder or any other person or corporation, or conveying any rights or permission to manufacture, use or sell any patented invention that may in any way be related thereto.
A performance model of broadcast communication in wormhole-routed hypercubes (2002)

Many analytical models of wormhole-routed networks have been proposed over the past few years. Most of these models, however, have been developed for unicast (or point-to-point) communication. There has been comparatively little activity in the area of analytical models of collective communication, such as broadcast. As a result, most existing studies have relied on simulation to evaluate the performance merits of collective communication algorithms. This paper presents a new analytical model for predicting broadcast latency in the hypercube. Results obtained through simulation experiments show that the model exhibits a good degree of accuracy in predicting message latency under different working conditions.
COMPUTERIZED INTEGRATED PROJECT MANAGEMENT SYSTEM FOR A MATERIAL PULL STRATEGY (2014)

The purpose of this paper is to present a computerized integrated project management system and report results of a survey on the effectiveness of the system. The system consists of a scheduling system, material management system, labor/equipment system, and safety/quality control system. The backbone system is a scheduling system that adopts a production planning system and a project scheduling system. The lowest level in the scheduling system is a daily work management system, which is linked to each functional management system (i.e. material management system, labor/equipment system, and safety/quality control system). The paper focuses on the material management and scheduling systems to implement a material “pull” system to reduce material inventories on site. Details of material management and scheduling systems are discussed, and a sample application is presented to demonstrate the features of the proposed computer application system. The paper presents practitioners and researchers with a practical tool to integrate material management and scheduling systems for site personnel.
GPU-based reconstruction and display for 4D ultrasound data (2009)

Due to the required computational effort of 4D ultrasound imaging, such systems depend on low complexity techniques like nearest neighbor interpolation, which affects volume quality. Moreover, more accurate techniques like normalized convolution, backward trilinear interpolation, and forward spherical and ellipsoidal Gaussian kernel, are avoided in real-time imaging because of the tight reconstruction time. The goal of this work is to utilize recent commercial graphics hardware technology of graphics processing unit (GPU) to speed up the reconstruction time while increasing the quality of displayed volume.
Machine Learning Approach to Model Physical Fatigue during Incremental Exercise among Firefighters (2022)

Physical fatigue is a serious threat to the health and safety of firefighters. Its effects include decreased cognitive abilities and a heightened risk of accidents. Subjective scales and, recently, on-body sensors have been used to monitor physical fatigue among firefighters and safety-sensitive professionals. Considering the capabilities (e.g., noninvasiveness and continuous monitoring) and limitations (e.g., assessed fatiguing tasks and models validation procedures) of current approaches, this study aimed to develop a physical fatigue prediction model combining cardiorespiratory and thermoregulatory measures and machine learning algorithms within a firefighters' sample. Sensory data from heart rate, breathing rate and core temperature were recorded from 24 participants during an incremental running protocol. Various supervised machine learning algorithms were examined using 21 features extracted from the physiological variables and participants' characteristics to estimate four physical fatigue conditions: low, moderate, heavy and severe. Results showed that the XGBoosted Trees algorithm achieved the best outcomes with an average accuracy of 82% and accuracies of 93% and 86% for recognising the low and severe levels. Furthermore, this study evaluated different methods to assess the models' performance, concluding that the group cross-validation method presents the most practical results. Overall, this study highlights the advantages of using multiple physiological measures for enhancing physical fatigue modelling. It proposes a promising health and safety management tool and lays the foundation for future studies in field conditions.
YaQ: An Architecture for Real-Time Navigation and Rendering of Varied Crowds (2009)

The YaQ software platform is a complete system dedicated to real-time crowd simulation and rendering. Fitting multiple application domains, such as video games and VR, YaQ aims to provide efficient algorithms to generate crowds comprising up to thousands of varied virtual humans navigating in large-scale, global environments.
Ketene-Based Route to rigid Cyclobutanediol Monomers for the Replacement of BPA in High Performance Polyesters (2012)

Recently, polyesters based on the diol monomer 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCBDO) have been shown to exhibit excellent thermal stability, mechanical properties, and optical clarity. In particular, the ability of TMCBDO to replace bisphenol A as a diol monomer in polycarbonates and polyesters has resulted in significant commercial and academic interest in these types of monomers. Herein, we report a versatile synthetic strategy based on the dimerization of ketenes derived from the thermal treatment of Meldrum's acid for the synthesis of structurally diverse cyclobutanediol (CBDO) monomers. This strategy allows a library of CBDO monomers amenable to standard polyester polymerization procedures to be prepared and the structural diversity of these CBDO monomers provides polymers with tunable physical properties, such as glass transition temperature ranging from 120 to 230 °C. The versatility and modularity of this Meldrum's acid-based approach to substituted cyclobutanediols, combined with the ease of synthesis, will be important for the further development of high-performance polyester materials that are not based on bisphenol A.
Comparison of Matrix Vesicles Derived from Normal and Osteoarthritic Human Articular Cartilage (1996)

Articular cartilage matrix vesicles (MVs) from normal human adult articular cartilage were examined for protein and enzyme content and biomineralizing capacity for comparison to MVs derived from human osteoarthritic (OA) cartilage. Femoral condylar and tibial plateau cartilage from each of 9 healthy donors ages 17-37 y was enzymatically digested and serially ultracentrifuged to pellet MV's at 3 x 10(6) g-min. MV protein content, nucleoside triphosphate pyrophospho hydrolase (NTPPPH) specific activity (SA) and capacity for 45Ca precipitation were determined. MV precipitated mineral was examined using Fourier transform infrared spectroscopy (FTIR). Normal human cartilage yields 50% less MV protein/g cartilage than OA cartilage (p < .01). Normal human articular MVs possess 30-70x higher NTPPPH SA than cell-free digest. Mean NTPPPH SAs of MVs derived from normal human cartilage are 3x higher than that of OA MVs (p < .05) and normal MV NTPPPH SA appears to decrease with age (p < .01). Normal human MVs support significantly higher calcium precipitation/mg MV protein in both ATP-dependent (p < .01) and -independent (p = .05) systems. The FTIR spectrum of MV mineral generated in the presence of ATP strongly resembles the standard spectrum for calcium pyrophosphate dihydrate (CPPD). The FTIR spectrum of MV mineral generated without ATP resembles that of carbonate-substituted apatite (AP). The fact that isolated MVs from normal cartilage generate pathologically relevant crystal phases in vitro implies that matrix integrity and substrate availability may be crucial factors in the control of pathologic biomineralization.
Isolation of 2-(4-hydroxybenzyl)malic acid from Petalostemon gattingeri (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of 2-(4-hydroxybenzyl)malic acid from Petalostemon gattingeriThomas M. Harris, James V. Hay, and Elsie QuartermanCite this: J. Org. Chem. 1973, 38, 26, 4457–4459Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://doi.org/10.1021/jo00965a025Request reuse permissionsArticle Views79Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (449 KB) Get e-Alertsclose Get e-Alerts
SACRAMENTO AREA REGIONAL ITS ARCHITECTURE (2002)

With the completion of Tier I and II National ITS workshops, SACOG and the Sacramento Region ITS Partnership initiated a project to complete the Regional ITS Architecture based on the information gathered during the workshop process. This paper discusses the process, which was followed throughout development of the Regional ITS Architecture focusing on the inclusion of stakeholder consensus within the region. The Paper also provides a high-level graphically representation of the completed Regional ITS Architecture, and covers some of the benefits relative to the deployment of ITS technology and solutions. Finally the paper recommends an approach for maintaining the Regional ITS Architecture, and local funding sources for the implementation of ITS
Minimal conformation of the ±‐conotoxin ImI for the ±7 neuronalnicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies (1999)

The alpha-ImI conotoxin, a selective potent inhibitor of the mammalian neuronal alpha7 nicotinic acetylcholine receptor (n-AchR), was shown by point mutation or by L-alanine scanning to display two regions essential for bioactivity: the active site Asp5-Pro6-Arg7 in the first loop and Trp10 in the second loop. The deletion of the Cys3,Cys12 disulfide bond in the alpha-ImI scaffold, e.g. peptide II, had no effect on its binding affinity. CD spectra, NMR studies and structure calculations were carried out on the wild type alpha-ImI, the weakest analog (R7A) and peptide II (equipotent to alpha-ImI) in order to point out the conformational differences between these compounds. Then, an attempt to correlate the conformational data and the affinity results was proposed. CD and NMR data were identical for the R7A analog and alpha-ImI, revealing the crucial functional role of the Arg7 side chain. On the other hand, the scaffold of the first loop in peptide II was shown by NMR to represent the minimal conformation for the optimal interaction of the toxin with the neuronal alpha7 n-AchR. Last, the beta-turn forming property of the 6th residue (Pro) in the active site of the alpha-ImI can be correlated with its affinity.
A low cost microburst early warning and detection radar (2002)

The microburst prediction radar is a new low cost airport weather surveillance radar. Intended for on-airport siting, the X-band radar features small size and low radiated power. The system provides 2-4 minutes warning and continuous detection of hazardous microburst wind shear within a 10 km radius. System cost is $500-700K, including installation.
Understanding the ability of low-cost MOx sensors to quantify ambient VOCs (2019)

Abstract. Volatile organic compounds (VOCs) present a unique challenge in air quality research given their importance to human and environmental health, and their complexity to monitor resulting from the number of possible sources and mixtures. New technologies, such as low-cost air quality sensors, have the potential to support existing air quality measurement methods by providing data in high time and spatial resolution. These higher-resolution data could provide greater insight into specific events, sources, and local variability. Furthermore, given the potential for differences in selectivities for sensors, leveraging multiple sensors in an array format may even be able to provide insight into which VOCs or types of VOCs are present. During the FRAPPE and DISCOVER-AQ monitoring campaigns, our team was able to co-locate two sensor systems, using metal oxide (MOx) VOC sensors, with a proton-transfer-reaction quadrupole mass spectrometer (PTR-QMS) providing speciated VOC data. This dataset provided the opportunity to explore the ability of sensors to estimate specific VOCs and groups of VOCs in real-world conditions, e.g., dynamic temperature and humidity. Moreover, we were able to explore the impact of changing VOC compositions on sensor performance as well as the difference in selectivities of sensors in order to consider how this could be utilized. From this analysis, it seems that systems using multiple VOC sensors are able to provide VOC estimates at ambient levels for specific VOCs or groups of VOCs. It also seems that this performance is fairly robust in changing VOC mixtures, and it was confirmed that there are consistent and useful differences in selectivities between the two MOx sensors studied. While this study was fairly limited in scope, the results suggest that there is the potential for low-cost VOC sensors to support highly resolved ambient hydrocarbon measurements. The availability of this technology could enhance research and monitoring for public health and communities impacted by air toxics, which in turn could support a better understanding of exposure and actions to reduce harmful exposure.
Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum (2009)

Human meibum was targetly analyzed for the presence of intact wax esters (WEs) and related compounds by means of reverse-phase HPLC in combination with ion trap mass spectrometry. The major detected WEs were based on C(18:n) (n = 1-4) unsaturated FAs ranking in the following order of abundance: C(18:1)>C(18:2)>C(18:3)>C(18:4). The major fatty alcohols (FAls) found in WE were of saturated nature and varied from C(18:0) to C(28:0). The three most abundant species were C(18:1)-FA esters of C(24:0), C(25:0), and C(26:0)-FAl. Typically, a major compound based on C(18:1)-FA and a saturated FAl was accompanied by a few related compounds based on a C(18:2), C(18:3), and C(18:4)-FA. Contrary to previous reports, no epoxy-WEs or epoxy-FAs were detected in fresh and 1-year-old meibum samples. More than 20 (O-acyl)-omega-hydroxy-FAs (OAHFAs) were observed. The main detected OAHFAs were based on very long-chain omega-hydroxy-FA (C(30:1), C(32:1), and C(34:1)) acylated through their omega-hydroxyls by a C(18:1)-FA. Due to their amphiphilic anionogenic nature, OAHFAs may be responsible for stabilization of the tear film lipid layer by creating an interface between the vast pool of strictly nonpolar lipids of meibum (WEs, cholesteryl esters, etc.) and the aqueous subphase beneath it, a role previously attributed to phospholipids.
Trigeminal Involvement in Parry–Romberg Syndrome (2015)

Bucher, Franziska MD; Fricke, Julia MD; Cursiefen, Claus MD; Heindl, Ludwig M. MD Author Information
Improved Thick Film Resistor Modelling and Prediction (1991)

This paper outlines the development and testing against data gathered from test resistors, of a theoretically based, enhanced accuracy, hybrid thick film resistor model. Software has been written in Pascal to run on a PC. The model has six empirically derived parameters and predicts resistance values for a wide range of resistor dimensions including those outside the usual design rules, allowing accurate extrapolation beyond the range of the test data. The paper opens with a general description of thick film resistors and critique of previous simpler models. We link the mathematical model to the physical dimensions and conduction processes, justifying the choice of Galonka's model as the basis of the improved model.
60GHz Radios: Enabling Next-Generation Wireless Applications (2005)

Up to 7 GHz of continuous bandwidth centred around 60 GHz has been allocated worldwide for license free wireless communications. Highly attenuated due to oxygen absorption and small in wavelength, this band is ideal for extremely high data rate wireless data applications. These include numerous WPAN/WLAN applications such as home multimedia streaming. Traditional RF circuits used in this band are based on expensive compound semiconductor technologies. However for viable consumer applications, alternatives must be found. SiGe and CMOS based circuits are showing promise for enabling this technology at a price within reach of the consumer. This paper summarises a joint project aimed at developing high rate consumer level mm-wave wireless data systems. In particular, results to date in our RF design efforts are summarised.
Study of methane hydrate as a future energy resource: low emission extraction and power generation (2016)

With the fast increase of world energy consumption in recent years, new and sustainable energy sources are becoming more and more important. Methane Hydrate is one promising candidate for the future energy supply of humankind, due to its vast existence in permafrost regions and near-coast seabed. This study is focused on the effective low emission utilization of methane hydrate from deep seabed. The Nankai Trough of Japan is taken as the target region in this study for methane hydrate extraction and utilization system design. Low emission system and power generation system with CCS (Carbon Capture and Sequestration) processes are proposed and analyzed for production rate and electricity generation efficiency problem study. It is found that the gas production price can reach the current domestic natural gas supply price level if the production rate can be improved. The optimized system is estimated to have power efficiency about 35%. In addition, current development and analysis from micro-to-macro scale methane hydrate production and dissociation dynamics are also discussed into detail in this study.
Density Functional Theory Study on the Effect of Substitution and Ring Annelation to the Rim of Corannulene (2004)

B3LYP/6-311G calculations indicate that annelation of a five-membered ring to the rim of corannulene and substitution to all the rim carbons lowers the barrier for bowl-to-bowl inversion. Singlet-triplet energy differences, frontier orbital analysis, and nucleus-independent chemical shift (NICS) values indicate significant enhancement of the reactivity when the substitutions involve exocyclic double bonds. Bowl-to-bowl inversion barrier, curvature, and reactivity for unsaturated and saturated five-membered ring-annelated corannulenes are analogous to decamethyl- and decamethylene-substituted corannulenes.
Temperature-dependent Sellmeier equation for the index of refraction, n_e, in congruent lithium niobate (1997)

A Sellmeier equation for the extraordinary index of congruent lithium niobate is derived. The source data for the fit contain previously published data [Opt.Commun.17, 322 (1996); erratum 20, 188 (1997); J.Appl.Phys. 45, 3688 (1974)] and new measured tuning data for an optical parametric oscillator using periodically poled lithium niobate. Phase-matching predictions are accurate for temperatures between room temperature and 250 degrees C and wavelengths ranging from 0.4 to 5 mum .