gebhart/patrepeval huggingface dataset:
Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin (2018)

The B subunit of the subtilase cytotoxin (SubB) recognises N-glycolylneuraminic acid (Neu5Gc) containing glycans, the most prominent form of aberrant glycosylation in human cancers. We have previously engineered SubB by construction of a SubBΔS106/ΔT107 mutant (SubB2M) for greater specificity and enhanced recognition of Neu5Gc containing glycans. In this study, we further explore the utility of SubB2M as a Neu5Gc lectin by showing its improved specificity and recognition for Neu5Gc containing glycans over the wild-type SubB protein and an anti-Neu5Gc IgY antibody in a N-acetylneuraminic acid (Neu5Ac)/Neu5Gc glycan array and by surface plasmon resonance. Far-western blot analysis showed that SubB2M preferentially binds to bovine serum glycoproteins over human serum glycoproteins. SubB2M was also able to detect Neu5Gc containing bovine glycoproteins spiked into normal human serum with greater sensitivity than the wild-type SubB and the anti-Neu5Gc IgY antibody. These results suggest that SubB2M will be a useful tool for the testing of serum and other bodily fluids for cancer diagnosis and prognosis.
Molecular Generation for Desired Transcriptome Changes With Adversarial Autoencoders (2020)

Gene expression profiles are useful for assessing the efficacy and side effects of drugs. In this paper, we propose a new generative model that infers drug molecules that could induce a desired change in gene expression. Our model-the Bidirectional Adversarial Autoencoder-explicitly separates cellular processes captured in gene expression changes into two feature sets: those <i>related</i> and <i>unrelated</i> to the drug incubation. The model uses <i>related</i> features to produce a drug hypothesis. We have validated our model on the LINCS L1000 dataset by generating molecular structures in the SMILES format for the desired transcriptional response. In the experiments, we have shown that the proposed model can generate novel molecular structures that could induce a given gene expression change or predict a gene expression difference after incubation of a given molecular structure. The code of the model is available at https://github.com/insilicomedicine/BiAAE.
CT Evaluation of Locally Advanced Carcinoma of the Distal Colon and Rectum (1983)

Computed tomography (CT) correctly identified extraluminal extension in carcinoma of the rectum and distal sigmoid in 20 patients who were deemed clinically inoperable because of tumor fixation. All patients received preoperative radiation therapy and subsequent surgical resection of the tumor. The findings at surgery corroborated the presence and location of tumor extension deep to the wall of the colon. Based on this preliminary data, further investigation into the place of CT in treatment planning of colon carcinomas is indicated.
A SURVEY OF PATIENTS WITH INFLATABLE PENILE PROSTHESES FOR SATISFACTION (2005)

There was a high degree of overall patient satisfaction across implant types.
The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging (2021)

LUM/IVA decreased lung hyperinflation in combination with a potential decrease in mucus impaction, which can be related to an improved mucociliary transport. These results indicate that several FRI parameters, reflecting regional and distal lung structures, are more sensitive to changes caused by LUM/IVA than conventional respiratory outcomes.
MGV: a generic graph viewer for comparative omics data (2011)

Supplementary data are available at Bioinformatics online.
Spectral-Spatial Hyperspectral Image Classification Using Extended Multi Attribute Profiles and Guided Bilateral Filter (2015)

The combination of spectral and spatial information for classification of hyper spectral image is an effective way in improving classification accuracy. In the paper, we proposed a new spectral-spatial method for textural feature extraction based on morphological attribute profiles and guided bilateral filter. Firstly, we obtained multi-level characters through the cascade of many attribute profiles to present the spatial and spectral information of remote sensing image. Then, bilateral filter preserved the edges of features with guide of the segmentation image generated by entropy rate super pixel algorithm. Finally, a pixel-wise classifier, e.g., Support vector machine and sparse representation, is used for classification based on the features. Experiments of two benchmark hyper spectral data sets showed better performance of the proposed method than other state-of-the-art methods.
SINGLE VERSUS MULTIPLE PANCREATIC STENTS IN CHRONIC PANCREATITIS: A RETROSPECTIVE COMPARATIVE STUDY (2018)

Stent insertion has been shown to be effective regarding pain resolution in patients with chronic pancreatitis (CP) and ductal strictures. It is not known if there is a benefit from inserting more than one stents, parallel one to the other. The aim of this study was to evaluate the outcome of pain in patients with painful PC who underwent insertion of a single versus multiple stents.
Canadian National Breast Screening Study: 1. Breast cancer detection and death rates among women aged 40 to 49 years. (1992)

The study was internally valid, and there was no evidence of randomization bias. Screening with yearly mammography and physical examination of the breasts detected considerably more node-negative, small tumours than usual care, but it had no impact on the rate of death from breast cancer up to 7 years' follow-up from entry.
Balanced bridge SAW impedance element filters (1994)

Over the last few years a new generation of Surface Acoustic Wave (SAW) devices with low loss and operating at high frequency have been invented to meet the demand of mobile communication systems. In this work we discuss a new class of SAW filters-balanced bridge impedance element filters,-which have numerous advantages: low insertion loss, extremely small size and weight, a wide variety of center frequencies and passbands, excellent suppression in the stopband and no external matching circuits
Molecular Characterization ofδ-Thalassemia in Iran (2016)

δ-Thalassemia (δ-thal) (OMIM #142000) resulting from mutations on the HBD gene usually has no clinical consequences. However, it may cause the misdiagnosis of β-thalassemia (β-thal) carriers by lowering the Hb A2 level to the normal range. Therefore, a study for δ-thal should be considered as a step in the detection of at-risk couple in our region. The aim of the present study was to characterize the mutations of the HBD gene in β-thal carriers with normal Hb A2 levels, and also in normal individuals with Hb A2 of less than 2.0%. Four β-thal carriers with normal Hb A2 and 39 individuals with Hb A2 of less than 2.0% were enrolled. Genomic DNA was extracted by the salting out method and the HBD gene was investigated by polymerase chain reaction (PCR) and direct DNA sequencing. Hb A2-Yialousa (HBD: c.82 G > T) was the most common variant found in the HBD gene, but the following mutations were also found: Hb A2-NYU (HBD: c.39 T > A), Hb A2-Coburg (HBD: c.350 G > A), Hb A2-Etolia (HBD: c.257 T > C), Hb A2-Fitzroy (HBD: c.428 C > A) and the δ-IVS-I-5 (G > T) (HBD: c.92 + 5 G > T). One case was a compound heterozygote for δ-IVS-I-5/Hb A2-Fitzroy. The results of this single center study suggest that the mutations in the HBD gene in the Iranian population are heterogeneous and should be considered in genetic counseling of families.
Porous biodegradable polyester blends of poly(L‐lactic acid) and poly(ε‐caprolactone): physical properties, morphology, and biodegradation (2006)

Abstract Poly( L ‐lactic acid) (PLLA), poly(ε‐caprolactone) (PCL), and their films without or blended with 50 wt% poly(ethylene glycol) (PEG) were prepared by solution casting. Porous films were obtained by water‐extraction of PEG from solution‐cast phase‐separated PLLA‐ blend ‐PCL‐ blend ‐PEG films. The effects of PLLA/PCL ratio on the morphology of the porous films and the effects of PLLA/PCL ratio and pores on the physical properties and biodegradability of the films were investigated. The pore size of the blend films decreased with increasing PLLA/PCL ratio. Polymer blending and pore formation gave biodegradable PLLA‐ blend ‐PCL materials with a wide variety of tensile properties with Young's modulus in the range of 0.07–1.4 GPa and elongation at break in the range 3–380%. Pore formation markedly increased the PLLA crystallinity of porous films, except for low PLLA/PCL ratio. Polymer blending as well as pore formation enhanced the enzymatic degradation of biodegradable polyester blends. Copyright © 2006 Society of Chemical Industry
What Changes Drug Metabolism in Critically 111 Patients? Two Preliminary Studies in Isolated Human Hepatocytes (1994)

PARK, G. R.; PICHARD, L.; TINEL, M.; LARROQUE, C.; ELSTON, A.; DOMERQUE, J.; DEXIONNE, B.; MAUREL, P. Author Information
Investigation of NOx Removal from Small Engine Exhaust (1999)

Contribution of emissions from small engines to the air pollution is significant. Due to differences in operating conditions and economics, the pollution control systems designed for automobiles will be neither suitable nor economically feasible for use on small engines. The objective of this project was to find a catalyst for the removal of NOx from the exhaust of small engines which use a rich air to fuel ratio. The desired catalyst should be inexpensive so that the cost of the pollution control unit will be only a small fraction of the total equipment cost. The high cost of noble metals makes them too expensive for use as NOx catalyst for small engines. Catalytic reduction of Nitrogen Oxide (NO) can also be accomplished by base-metal oxide catalysts. The main disadvantage of base-metal catalysts is their deactivation by poisons and high temperatures. Requirements for the length of the life of the small engine exhaust catalysts are much less than those for automobile exhaust catalysts. Since there is no oxygen in the exhaust gases, reduction selectivity is not a problem. Also, the reducing exhaust gases might help prevent the harmful interactions of the catalyst with the support. For these reasons only the supported metal oxide catalysts were investigated in this project.
Interleukin‐4 inhibits the expression of tumour necrosis factors α and β, interleukins‐1 β and ‐6 and interferon‐γ (1995)

T cell-derived IL-4 inhibits the expression of several inflammatory cytokine genes. In this study, IL-4 downregulated TNF-alpha and -beta, IL-1 beta IL-6 and IFN-gamma steady-state mRNA and protein production by blood leukocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL-4, suggesting an early and prolonged downregulatory effect. These findings support the general thesis that IL-4 is an important regulator of the inflammatory immune response.
A Multi-Physics 3D Modeling Methodology for Multi-Cylinder Diesel Engine Thermal Management and Fatigue Life Prediction (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Durability assessments of modern engines often require accurate modeling of thermal stresses in critical regions such as cylinder head firedecks under severe cyclic thermal loading conditions. A new methodology has been developed and experimentally validated in which transient temperature distributions on cylinder head, crankcase and other components are determined using a Conjugate Heat Transfer (CHT) CFD model and a thermal finite element analysis solution. In the first stage, cycle-averaged gas side boundary conditions are calculated from heat transfer modeling in a transient in-cylinder simulation. In the second stage, a steady-state CHT-CFD analysis of the full engine block is performed. Volume temperatures and surface heat transfer data are subsequently transferred to a thermal finite element model and steady state solutions are obtained which are validated against CFD and experimental results. With the goal of emulating an engine test strategy for durability under extreme warm up and cool down cycles, a transient thermal analysis is performed for several loading cycles. Simulated transient temperature traces demonstrate good agreement with time-varying thermocouple measurements on the cylinder head. Temperature distributions at many times during the thermal shock test are utilized to calculate thermal stresses followed by a fatigue life analysis. It is demonstrated that transient thermal stress modeling is critical for the fatigue predictions at some locations on the cylinder head. This comprehensive methodology significantly improves the fidelity of engine thermal management and durability prediction and reduces the cost of engine development under severe fatigue prone conditions.&lt;/div&gt;&lt;/div&gt;
Improved Tx-to-Rx isolation with balanced radar front-end (2004)

This paper presents a balanced radar front-end MMIC to reduce Tx leakage at receiver. The radar front-end MMIC is composed of a differential cross-coupled oscillator, two differential amplifiers, two Lange couplers, and a Wilkinson combiner, which are implemented using low cost InCaP/GaAs HBT technology. The differential cross-coupled VCO shows the tuning range of 70 MHz from 22.767 GHz to 22.837 GHz. The peak output power is 0 dBm. The phase noise of VCO is -98.33 dBc/Hz at 1 MHz offset frequency. High Tx-to-Rx isolation of 50 dB is achieved in the balanced radar front-end. The additional cancellation due to balanced topology is expected to be 29.5 dB. The chip size is 2.25 x 1.75 mm2.
Les anti-plaquettaires sans risque de saignement : nouvelles cibles et stratégies (2015)

Anti-platelet agents such as aspirin, clopidogrel and antagonists of integrin αIIbβ3 allowed to efficiently reduce morbidity and mortality associated with arterial thrombosis. A major limit of these drugs is that they increase the risk of bleeding. During the last few years, several innovative anti-thrombotic strategies with a potentially low bleeding risk were proposed. These approaches target the collagen receptor glycoprotein (GP) VI, the GPIb/von Willebrand factor axis, the thrombin receptor PAR-1, the activated form of integrin αIIbβ3 or the ADP receptor P2Y1. While an antagonist of PAR-1 was recently marketed, the clinical proofs of the efficiency and safety of the other agents remain to be established. This review evaluates these new anti-platelet approaches toward safer anti-thrombotic therapies.
Tendon re-attachment to metal prostheses in an in vivo animal model using demineralised bone matrix (2009)

We used demineralised bone matrix (DBM) to augment re-attachment of tendon to a metal prosthesis in an in vivo ovine model of reconstruction of the extensor mechanism at the knee. We hypothesised that augmentation of the tendon-implant interface with DBM would enhance the functional and histological outcomes as compared with previously reported control reconstructions without DBM. Function was assessed at six and 12 weeks postoperatively, and histological examination was undertaken at 12 weeks. A significant increase of 23.5% was observed in functional weight-bearing at six weeks in the DBM-augmented group compared with non-augmented controls (p = 0.004). By 12 weeks augmentation with DBM resulted in regeneration of a more direct-type enthesis, with regions of fibrocartilage, mineralised fibrocartilage and bone. In the controls the interface was predominantly indirect, with the tendon attached to the bone graft-hydroxyapatite base plate by perforating collagen fibres.
Do Locking Screws Work in Plates Bent at Holes? (2013)

Bending of a 3.5-mm locking compression plate by more than 5 degrees at a locking hole results in a statistically significant decrease in survival of the corresponding locked screw. This effect cannot be prevented by the placement of a threaded screw head insert before bending.
Spinal stenosis with meralgia paraesthetica (1988)

Of 232 patients with evidence of lumbar spinal stenosis, 13 had symptoms of meralgia paraesthetica. Myelography demonstrated that in all but one of these 13 cases the L3-4 level was involved by stenosis; in 12 matched control patients with spinal stenosis, none had involvement at this level. We found that both the ligamentum flavum and the laminae at L3-4 level were thicker than in a control group. Decompressive laminectomy at the L3-4 level significantly reduced the area of hypo-aesthesia in the thigh, effecting complete cure in seven of the 11 cases. Meralgia paraesthetica is not uncommon in patients with spinal stenosis and is referable to changes at the L3-4 level. It seems that many cases of meralgia may have a spinal origin.
Increased Pressure Pain Sensitivity in Women With Chronic Pelvic Pain (2013)

II.
Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review (2013)

5ARIs are associated with slightly increased rates of decreased libido, ED, EjD, gynecomastia, depression, and/or anxiety. Further studies directed at identifying prevalence rates and persistence of symptoms beyond drug discontinuation are required to assess causality. Trost L, Saitz TR, and Hellstrom WJG. Side effects of 5-alpha reductase inhibitors: A comprehensive review. Sex Med Rev 2013;1:24-41.
Remote attestation to dynamic system properties: Towards providing complete system integrity evidence (2009)

Remote attestation of system integrity is an essential part of trusted computing. However, current remote attestation techniques only provide integrity proofs of static properties of the system. To address this problem we present a novel remote dynamic attestation system named ReDAS (Remote Dynamic Attestation System) that provides integrity evidence for dynamic system properties. Such dynamic system properties represent the runtime behavior of the attested system, and enable an attester to prove its runtime integrity to a remote party. ReDAS currently provides two types of dynamic system properties for running applications: structural integrity and global data integrity. In this work, we present the challenges of remote dynamic attestation, provide an in-depth security analysis and introduce a first step towards providing a complete runtime dynamic attestation framework. Our prototype implementation and evaluation with real-world applications show that we can improve on current static attestation techniques with an average performance overhead of 8%.
Electromagnetic field of currents over generalised surface elements (1994)

This chapter is devoted to derivation of expressions for the electromagnetic fields due to known distributions of currents over arbitrary curvilinear rectangles, over bilinear surfaces, and along generalised wires and truncated cones. The first step is determination of the Lorentz potentials, from which the electric and magnetic-field vectors in the near and far zones are then evaluated.
Earlier Onset of δ-Retrovirus-Induced Leukemia after Splenectomy (2009)

Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts will develop either lymphoproliferative or neurodegenerative diseases after long latency periods. In fact, the host immune response is believed to tightly control viral replication but this assumption has not been definitely proven in vivo. Here, we provide direct experimental evidence demonstrating that integrity of the spleen is required to control pathogenesis. In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia. These observations enlighten a potential threat in splenectomized HTLV-1 carriers and justify a regular preventive evaluation.
Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)∗ (1986)

GnRH analogs inhibit the secretion of gonadotropins and, therefore, that of estrogens and androgens of ovarian origin. The purpose of this study was to investigate the use of one superactive agonistic GnRH analog, nafarelin, in the treatment of hirsutism. Six hirsute women were treated with nafarelin (1 000 micrograms/day) for 6 months. An acute rise in serum gonadotropin levels occurred in response to nafarelin administration initially, but it lasted less than 2 weeks. Serum gonadotropin, testosterone, free testosterone, and androstenedione concentrations decreased significantly during treatment. Mean serum LH levels decreased from 17.9 +/- 4.6 (+/- SE) to 5.0 +/- 0.5 mIU/ml (P less than 0.01), and FSH decreased from 9.3 +/- 0.7 to 7.2 +/- 0.9 mIU/ml (P less than 0.05) after 1 month of treatment. The total testosterone concentration fell from 0.77 +/- 0.10 to 0.40 +/- 0.14 ng/ml (P less than 0.01) after 1 month of therapy, and free testosterone decreased from 10.7 +/- 2.7 to 4.1 +/- 1.6 pg/ml (P less than 0.01) after 3 months. Androstenedione levels decreased from 2.4 +/- 0.4 to 1.2 +/- 0.2 ng/ml (P less than 0.01) after 1 month of treatment. The mean concentrations of all of the above hormones remained suppressed throughout treatment. Serum 5 alpha-androstane-3 alpha,17 beta-diol glucuronide levels did not decrease significantly during treatment, nor did dehydroepiandrosterone sulfate levels. The mean estradiol concentration during treatment was 34.8 +/- 3.1 pg/ml. The clinical response was very good; hair growth was slower, and new hair was less coarse compared to the pretreatment period. Hirsutism scores (determined by Ferriman-Gallwey assessment of extent and quality of body hair) improved in four of the six patients. In the six patients, the mean score decreased significantly from 19.3 +/- 3.3 to 13.2 +/- 2.8 (P less than 0.05) at the end of treatment. These data demonstrate that by suppressing ovarian androgen production, nafarelin may be useful for the treatment of hirsutism associated with either increased ovarian androgen production or increased sensitivity of the hair follicle to normal concentrations of circulating androgens.
The expression of receptors for IgA on human monocytes and calcitriol-treated HL-60 cells. (1985)

In this study, we investigated the expression of IgA Fc receptors (FcR alpha) by human myeloid cells. By using a sensitive cytofluorometric IgA binding assay, we found that approximately 85% of peripheral blood monocytes bound IgA in an isotype-specific fashion. The HL-60 human promyelocytic leukemia cell line failed to express FcR alpha; however, treatment of HL-60 cells with the differentiating agent calcitriol induced the expression of FcR alpha on greater than 90% of these cells. Monocytes and calcitriol-treated HL-60 cells were capable of ingesting IgA-coated erythrocyte targets, suggesting that phagocytosis could be mediated through FcR alpha. The induced HL-60 cell system represents a useful model for further studies on FcR alpha expression and function.
Mathematical Logic in Computer Science (2018)

The article retraces major events and milestones in the mutual influences between mathematical logic and computer science since the 1950s.
Digital 2-/3-Phase Switched-Capacitor Converter With Ripple Reduction and Efficiency Improvement (2017)

This paper presents a digitally controlled 2-/3-phase 6-ratio switched-capacitor (SC) dc-dc converter with low output voltage ripple and high efficiency. To achieve wide input and output voltage ranges, six voltage conversion ratios are generated with only two discrete flying capacitors by using both 2and 3-phase operations. An adaptive ripple reduction scheme is proposed to achieve up to four times reduction in the output voltage ripple. The complexity of controller design is reduced by using digital synthesis, and the technique is scalable with process. Fast loop response is achieved by using synchronized hysteretic control. The SC converter was fabricated in a 0.13-μm CMOS process. It can deliver a maximum power of 250 mW to an output of 0.5-3 V with a wide input voltage range of 1.6-3.3 V. Compared to an SC converter with only 2-phase operation, the maximum efficiency improvement is 20%. The converter achieves a peak efficiency of 91%.