gebhart/patrepeval huggingface dataset:
Cyclic voltammetry experiment (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic voltammetry experimentJames J. Van Benschoten , Jane Y. Lewis , William R. Heineman , Daryl A. Roston , and Peter T. Kissinger Cite this: J. Chem. Educ. 1983, 60, 9, 772Publication Date (Print):September 1, 1983Publication History Received3 August 2009Published online1 September 1983Published inissue 1 September 1983https://doi.org/10.1021/ed060p772RIGHTS & PERMISSIONSArticle Views13471Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
An effective hybrid transactional memory system with strong isolation guarantees (2007)

We propose signature-accelerated transactional memory (SigTM), ahybrid TM system that reduces the overhead of software transactions. SigTM uses hardware signatures to track the read-set and write-set forpending transactions and perform conflict detection between concurrent threads. All other transactional functionality, including dataversioning, is implemented in software. Unlike previously proposed hybrid TM systems, SigTM requires no modifications to the hardware caches, which reduces hardware cost and simplifies support for nested transactions and multithreaded processor cores. SigTM is also the first hybrid TM system to provide strong isolation guarantees between transactional blocks and non-transactional accesses without additional read and write barriers in non-transactional code.Using a set of parallel programs that make frequent use of coarse-grain transactions, we show that SigTM accelerates software transactions by 30% to 280%. For certain workloads, SigTM can match the performance of a full-featured hardware TM system, while for workloads with large read-sets it can be up to two times slower. Overall, we show that SigTM combines the performance characteristics and strong isolation guarantees of hardware TM implementations with the low cost and flexibility of software TM systems.
Management of Chemotherapy Induced Cardiomyopathy (2012)

Chemotherapy related cardiac dysfunction (CRCD) is a serious complication of anticancer therapy. CRCD can be classified into two types. Type I CRCD is exemplified by anthracyline- induced cardiac dysfunction and type II CRCD is exemplified by trastuzumab- induced cardiac dysfunction. The mechanism of cardiac toxicity in both types is not well defined. Certain risk factors may play a role in developing the cardiac injury, most importantly, the cumulative dose when dealing with anthracycline induced cardiotoxicity. Establishing an early diagnosis and initiating early treatment may be an important step in preventing irreversible cardiac injury especially in type I CRCD. Currently there are no guidelines developed specifically for the treatment of chemotherapy induced cardiomyopathy (CIC), however a few small studies support the use of neurohormonal antagonists in the treatment and prevention of CIC. Large multi- centers trials are needed to establish guidelines for CIC. Until then, we advocate following the American College of Cardiology/ American Heart Association (ACC/AHA) and Heart Failure Society of America (HFSA) guidelines. Additionally, a close collaboration between the patient's cardiologist and oncologist is strongly recommended in order to establish a long term plan for the patient.
Origin of Enhanced Reducibility/Oxygen Storage Capacity of Ce1-xTixO2 Compared to CeO2 or TiO2 (2006)

We determine chemical origins of increase in the reducibility of CeO2 upon Ti substitution using a combination of experiments and first-principles density functional theory calculations. Ce1-xTixO2 (x = 0.0−0.4) prepared by a single step solution combustion method crystallizes in a cubic fluorite structure, confirmed by Rietveld profile analysis. Ce1-xTixO2 can be reduced by hydrogen to a larger extent compared to CeO2 or TiO2. Temperature programmed reduction of CeO2, TiO2, Ce0.75Ti0.25O2 and Ce0.6Ti0.4O2 up to 700 °C in H2 gave CeO1.96, TiO1.92, Ce0.75Ti0.25O1.81, and Ce0.6Ti0.4O1.73, respectively. An extended X-ray absorption fine structure (EXAFS) study of mixed oxides at the Ti K-egde showed that the local coordination of Ti is 4:4, with Ti−O distances of 1.9 and 2.5 Å, respectively, which are also confirmed by our first-principles calculations. Bond valence analysis of the microscopic structure and energetics determined from first principles is used to evaluate the strength of binding of different oxygen atoms and vacancies. We find the presence of strongly and weakly bound oxygens in Ce1-xTixO2, of which the latter are responsible for the higher oxygen storage capacity in the mixed oxides than in pure CeO2.
Semaphorin Signaling in Cancer-Associated Inflammation (2019)

The inflammatory and immune response elicited by the growth of cancer cells is a major element conditioning the tumor microenvironment, impinging on disease progression and patients' prognosis. Semaphorin receptors are widely expressed in inflammatory cells, and their ligands are provided by tumor cells, featuring an intense signaling cross-talk at local and systemic levels. Moreover, diverse semaphorins control both cells of the innate and the antigen-specific immunity. Notably, semaphorin signals acting as inhibitors of anti-cancer immune response are often dysregulated in human tumors, and may represent potential therapeutic targets. In this mini-review, we provide a survey of the best known semaphorin regulators of inflammatory and immune cells, and discuss their functional impact in the tumor microenvironment.
Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis (2020)

The homology-independent targeted integration (HITI) strategy enables effective CRISPR/Cas9-mediated knockin of therapeutic genes in nondividing cells in vivo, promising general therapeutic solutions for treating genetic diseases like X-linked juvenile retinoschisis. Herein, supramolecular nanoparticle (SMNP) vectors are used for codelivery of two DNA plasmids-CRISPR-Cas9 genome-editing system and a therapeutic gene, Retinoschisin 1 (RS1)-enabling clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) knockin of the RS1 gene with HITI. Through small-scale combinatorial screenings, two SMNP vectors, with Cas9 and single guide RNA (sgRNA)-plasmid in one and Donor-RS1 and green fluorescent protein (GFP)-plasmid in the other, with optimal delivery performances are identified. These SMNP vectors are then employed for CRISPR/Cas9 knockin of RS1/GFP genes into the mouse Rosa26 safe-harbor site in vitro and in vivo. The in vivo study involves intravitreally injecting the two SMNP vectors into the mouse eyes, followed by repeated ocular imaging by fundus camera and optical coherence tomography, and pathological and molecular analyses of the harvested retina tissues. Mice ocular organs retain their anatomical integrity, a single-copy 3.0-kb RS1/GFP gene is precisely integrated into the Rosa26 site in the retinas, and the integrated RS1/GFP gene is expressed in the retinas, demonstrating CRISPR/Cas9 knockin of RS1/GFP gene.
SMEs can touch Industry 4.0 in the Smart Learning Factory (2019)

This paper describes how a Smart Learning Factory enables manufacturing SMEs of capturing the benefits of highly complex tools and enablers such as virtual simulation and the Digital Twin. The collaborative factory design approach is enabled by embedding the use of discrete event simulation connected with physical objects placed on a Digital Twin Module (DTM). The users can manipulate the physical objects as physical counterparts to the machines and equipment in the virtual space and visualize the designed factory and make further analysis. The method combines the use of dynamic discrete event simulation seamlessly connected with physical objects placed on the DTM to enable collaborative design. The bridging between simulation and physical objects is done by using a digital integration platform. Using physical artifacts as counterparts of the virtual objects in the simulation, participants confidently interact with the simulation regardless level of skills and competencies. The Smart Learning Factory is helping SMEs to get inspired using physical and virtual simulations for factory design and re-design, and develop solutions in a collaborative environment. This is in-line with the theory of lean automation, that suggests making simple and cheap automation and automating the correct value-adding processes. A demonstration case of designing a production setup in cooperation with a SME is developed and documented.
Large-signal and small-signal models for arbitrarily-doped four-terminal field-effect transistors (1966)

Models are derived for a four-terminal field-effect transistor (FTFET) with an arbitrary (one-dimensional) impurity distribution. The models apply for both four-terminal and conventional three-terminal devices operated in either the pinch-off or nonpinch-off modes; moreover, they describe behavior when either large or small signals are applied to the gates. The model parameters can be determined either from terminal measurements or from knowledge of the physical make-up. Because an arbitrary impurity distribution is assumed in their derivation, the models represent devices made with any of the common fabrication techniques. Measured step-function response of epitaxial, single-diffused and double-diffused FTFET's shows good agreement with calculated behavior for broad ranges of resistive source and load terminations.
<title>Using MTF to evaluate optical systems employing unusual optics</title> (1995)

With the proliferation of aspheric and unusual optical surfaces in many optical systems, manufacturers are finding that conventional optical metrology methods are no longer suitable when characterizing these systems. For example, monochromatic interferometric measurements of individual components are being replaced by methods which determine system performance by analyzing the actual image produced by the optical system. This presentation will cover MTF and how it is used to characterize optical assemblies and systems employing unusual optical components.
NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis (2018)

Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac metabolic rewiring and if this process is driven by local inflammation. Transcriptomic analysis of cardiac biopsies from myocarditis patients and a mouse model of VM revealed prominent reductions in the expression of a multitude of genes involved in mitochondrial oxidative energy metabolism. In mice, this coincided with reductions in high-energy phosphate and NAD levels, as determined by Imaging Mass Spectrometry, as well as marked decreases in the activity, protein abundance and mRNA levels of various enzymes and key regulators of cardiac oxidative metabolism. Indicative of fulminant cardiac inflammation, NF-κB signalling and inflammatory cytokine expression were potently induced in the heart during human and mouse VM. In cultured cardiomyocytes, cytokine-mediated NF-κB activation impaired cardiomyocyte oxidative gene expression, likely by interfering with the PGC-1 (peroxisome proliferator-activated receptor (PPAR)-γ co-activator) signalling network, the key regulatory pathway controlling cardiomyocyte oxidative metabolism. In conclusion, we provide evidence that acute VM is associated with extensive cardiac metabolic remodelling and our data support a mechanism whereby cytokines secreted primarily from infiltrating leukocytes activate NF-κB signalling in cardiomyocytes thereby inhibiting the transcriptional activity of the PGC-1 network and consequently modulating myocardial energy metabolism.
Of diamond surfaces, red light photobiomodulation and fertility: lessons from the laboratory (2017)

There is hardly a day that goes by in my various professional roles as scientist, science watcher or clinician without encountering new information or a new scenario that highlights the complexity of biology and biological systems. Such occurrences warrant careful evaluation and oftentimes lead to new management strategies or form the basis for further scientific investigation. This is inevitable as the knowledge base expands and our understanding of the variables potentially impacting our strategies and outcomes increases. We continually learn, re-learn and refine what we do and how we do it. The survival and performance of human spermatozoa in vitro is one evolving story that has far-reaching implications in numerous fields in addition to human reproduction.
Functional organization within the medullary reticular formation of intact unanesthetized cat. I. Movements evoked by microstimulation (1990)

1. The present article described the various patterns of movement evoked in the limbs and neck by microstimulation (33-ms trains, 330 Hz, 0.2-ms pulses at less than or equal to 35 microA) of the medullary reticular formation (MRF) of seven chronically implanted, unanesthetized, intact cats. Altogether 878 loci were stimulated in 83 penetrations. However, as stimulation in the more lateral regions of the MRF was less effective, the results are based on stimulation in 592 loci made in 56 penetrations at distances of between 0.5 and 2.5 mm lateral to the midline. 2. Of these 592 loci, movement of one or more parts of the body was evoked from a total of 539 (91%) sites. Most of these movements were compound in nature, involving movement of one or more limbs as well as the head. Discrete movements were observed only with respect to the head; limb movements were always accompanied by head movement. In addition, hindlimb movements were always accompanied by forelimb movements, although the inverse was generally not true. 3. The most common effects of the stimulation were as follows: a turning of the head to the ipsilateral side (79% of stimulated sites); flexion of the ipsilateral elbow (41%); and extension of the contralateral elbow (45%). Effects in the hindlimbs were more variable and less frequent, with the majority of the effective loci causing flexion of the ipsilateral knee (9%) together with extension of the contralateral knee (8%). In total, including both flexion and extension, 18% of the stimulated sites caused movement of the ipsilateral hindlimb and 11% of the contralateral hindlimb. 4. Although movements of the head were obtained from the whole extent of the brain stem, movements of the forelimbs showed a dorsoventral organization with flexion of the ipsilateral elbow being evoked from the more dorsal regions of the brain stem, whereas contralateral elbow extension was evoked more frequently from the ventral regions. There was a large area of overlap from which movements of both limbs could be obtained simultaneously. Movements of the hindlimbs were more frequently evoked from central and ventral areas of the brain stem and from the most rostral aspect of the explored region. 5. In examining the combinations of movements evoked by the MRF stimulation, it was found that the most commonly evoked pattern was movement of the head to the stimulated side together with flexion of the ipsilateral forelimb and extension of the contralateral forelimb (26.5% of sites).(ABSTRACT TRUNCATED AT 400 WORDS)
Anti-CD4 Monoclonal Antibody Ibalizumab Exhibits Breadth and Potency Against HIV-1, With Natural Resistance Mediated by the Loss of a V5 Glycan in Envelope (2012)

Ibalizumab breadth and potency compared favorably with broadly neutralizing anti-HIV-1 monoclonal antibodies, supporting the clinical development of ibalizumab, alone or in combination, for HIV-1 prevention.
Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation. (1992)

BACKGROUND Shear-induced platelet aggregation (SIPA) is an important mechanism in thrombogenesis. von Willebrand factor (vWF) binding to platelet glycoprotein Ib (GP Ib) has been found to be crucial for platelet aggregation under the high shear force probably generated in stenosed coronary artery. The physiological significance of vWF-dependent SIPA has not been clarified. METHODS AND RESULTS Blood samples were collected from 23 normal volunteers. SIPA was continuously monitored using a modified cone-plate viscometer adapted for measuring the transmitted light intensity of the material. The effects of low concentrations of epinephrine, ADP, and collagen on SIPA under both low shear (12 dyne/cm2) and high shear (108 dyne/cm2) force were investigated. All agonists tested enhanced SIPA under low shear force, whereas only epinephrine augmented SIPA under high shear force. The maximum extents of SIPA under high shear force in the absence and presence of epinephrine (10 ng/ml) were 37.9 +/- 11.5% and 59.7 +/- 13.9%, respectively. The antagonist of the alpha 2-adrenergic receptor yohimbine (1 microgram/ml) antagonized the effects of epinephrine. The monoclonal antibody NMC-4 against vWF, which was shown to inhibit its binding to GP Ib, completely abolished SIPA under high shear force, even in the presence of epinephrine. However, this antibody only partially inhibited SIPA under low shear force. CONCLUSIONS Our findings suggest that epinephrine is the agonist that enhances SIPA mediated by vWF through its specific receptor. This may be clinically important because occlusion of the coronary artery often occurs in stenosed atherosclerotic vessels under sympathetic stimulation.
Frozen light in periodic stacks of anisotropic layers (2005)

We consider a plane electromagnetic wave incident on a periodic stack of dielectric layers. One of the alternating layers has an anisotropic refractive index with an oblique orientation of the principal axis relative to the normal to the layers. It was shown recently that an obliquely incident light, upon entering such a periodic stack, can be converted into an abnormal axially frozen mode with drastically enhanced amplitude and zero normal component of the group velocity. The stack reflectivity at this point can be very low, implying nearly total conversion of the incident light into the frozen mode with huge energy density, compared to that of the incident light. Supposedly, the frozen mode regime requires strong birefringence in the anisotropic layers--by an order of magnitude stronger than that available in common anisotropic dielectric materials. In this paper we show how to overcome the above problem by exploiting higher frequency bands of the photonic spectrum. We prove that a robust frozen mode regime at optical wavelengths can be realized in stacks composed of common anisotropic materials, such as YVO(4), LiNbO(3), CaCO(3), and the like.
Lenvatinib induces death of human hepatocellular carcinoma cells harboring an activated FGF signaling pathway through inhibition of FGFR–MAPK cascades (2019)

Lenvatinib inhibits VEGF- and FGF-driven angiogenesis, and proliferation of tumor cells with activated FGF signaling pathways in preclinical models, and we previously demonstrated antitumor activity in human HCC xenograft tumor models. Here, we examined the inhibitory activity of lenvatinib against FGF-driven survival of human HCC cell lines. First, we conducted a histological analysis of FGF19-overexpressing Hep3B2.1-7 xenograft tumors collected from mice treated with lenvatinib. Second, we examined the effects of pharmacological inhibition on survival of cultured HCC cells with an activated FGF signaling pathway under nutrient-starved culture condition to mimic tumor microenvironments induced by angiogenesis inhibition. In the first analysis, area of histological focal necrosis was greater in Hep3B2.1-7 xenograft tumors with the lenvatinib treatment than that after the treatment with sorafenib, which does not inhibit FGFRs. Lenvatinib and E7090 (a selective FGFR1-3 inhibitor), but not sorafenib, induced death of Hep3B2.1-7, and another FGF19 overexpressing HuH-7 cells. Lenvatinib and E7090 decreased phosphorylation of downstream molecules of the FGF signaling pathway (such as FRS2, Erk, and p38 MAPK), and induced PARP cleavage, even under limited nutrients. PD0325901, MEK inhibitor, caused the same changes in HCC cells as those described above for lenvatinib and E7090. These results reveal that the FGF signaling pathway through MAPK cascades plays an important role in survival of HCC cell lines with an activated FGF signaling pathway under limited nutrients, and FGFR-MAPK cascades likely contribute to survival of HCC cells with an activated FGF signaling pathway under tumor microenvironments with limited nutrients, where tumor angiogenesis is inhibited.
Dopamine D2 receptor signaling on iMSNs is required for initiation and vigor of learned actions (2020)

Striatal dopamine D2 receptors (D2Rs) are important for motor output. Selective deletion of D2Rs from indirect pathway-projecting medium spiny neurons (iMSNs) impairs locomotor activities in a task-specific manner. However, the role of D2Rs in the initiation of motor actions in reward seeking and taking is not fully understood, and there is little information about how receptors contribute under different task demands and with different outcome types. The iMSN-D2Rs modulate neuronal activity and synaptic transmission, exerting control on circuit functions that may play distinct roles in action learning and performance. Selective deletion of D2Rs on iMSNs resulted in slower action initiation and response rate in an instrumental conditioning task, but only when performance demand was increased. The iMSN-Drd2KO mice were also slower to initiate swimming in a T-maze procedural learning task but were unimpaired in cognitive function and behavioral flexibility. In contrast, in a Pavlovian discrimination learning task, iMSN-Drd2KO mice exhibited normal acquisition and extinction of rewarded responding. The iMSN-Drd2KO mice showed performance deficits at all phases of rotarod skill learning. These findings reveal that dopamine modulation through iMSN-D2Rs influences the ability to self-initiate actions, as well as the willingness and/or vigor with which these responses are performed. However, these receptors seem to have little influence on simple associative learning or on stimulus-driven responding. The loss of normal D2R roles may contribute to disorders in which impaired dopamine signaling leads to hypokinesia or impaired initiation of specific voluntary actions.
ChemInform Abstract: CONDENSATION OF 2‐PENTENYLFURAN WITH ALIPHATIC AND AROMATIC ALDEHYDES CATALYZED BY CATION EXCHANGE RESINS: PREPARATION OF A NEW CLASS OF TRISUBSTITUTED METHANE DERIVATIVES (1983)

Abstract Bei der Umsetzung des Pentenylfurans (I) mit den Aldehyden (II) in Gegenwart von Lewatit SP 120 (III) erhält man die Difuranylmethan‐Derivate (IV).