gebhart/patrepeval huggingface dataset:
Synthesis of Glyco‐Silicas by Cu(I)‐Catalyzed “Click‐Chemistry” and their Applications in Affinity Chromatography (2006)

Abstract The covalent immobilization of suitable alkyne/azide carbohydrate derivatives on complementarily functionalizated azide/alkyne silica was performed by click ligation througth the Cu(I)‐catalyzed 1,3‐dipolar cycloaddition reaction of such compounds. The new glyco‐silicas have shown to be efficient and valuable bio‐selective affinity chromatographic supports for the purification of lectins as well as for the one‐pot fluorescent labeling of those proteins. The synthetic methodology is simple, high yielding and flexible, allowing the preparation of tailored glyco‐silicas with potential future applications in the inmobilization of other biomolecules.
A Novel Candidate Compound with Urethane Structure for Anticancer Drug Development (2007)

Diethyl-4,4'-methylenebis(N-phenylcarbamate) (MDU) is a urethane compound that we originally synthesized, along with three other compounds, to investigate how polyurethane is hydrolysed. We tested the four compounds for cytotoxicity in two Chinese hamster cell lines (CHL and V79) and a human cancer cell line (HeLa S3). MDU showed the strongest cytotoxicity in all the cell lines with an IC50 of around 0.1 microg/ml. We further investigated MDU for its ability to induce chromosome aberrations (CAs) and micronuclei (MN) in CHL cells. MDU induced around 100% polyploid cells at 0.5 microg/ml after 24- and 48-h treatment in the CA test and a significantly increased frequency of micronuclei, polynuclear cells, and mitotic cells in the MN test, suggesting that it may induce numerical CAs. MDU's ability to cause mitotic arrest in CHL cells was greater than that of taxol and colchicine. Based on a COMPARE analysis using JFCR39, a panel of cancer cell lines, we predicted MDU to be a tubulin inhibitor. We confirmed this possibility in nerve growth factor-stimulated PC12 cells as well as in HT1080 cells, in which MDU exhibited the activity to inhibit tubulin polymerization. MDU is simpler in structure than existing anticancer drugs taxol and vincristine and can be synthesized relatively easily. Here we offer MDU as a potential new type of anticancer drug, stable even at room temperature, and inexpensive.
Spent fuel sabotage test program, characterization of aerosol dispersal : interim final report. (2008)

This multinational, multi-phase spent fuel sabotage test program is quantifying the aerosol particles produced when the products of a high energy density device (HEDD) interact with and explosively particulate test rodlets that contain pellets of either surrogate materials or actual spent fuel. This program provides source-term data that are relevant to plausible sabotage scenarios in relation to spent fuel transport and storage casks and associated risk assessments. We present details and significant results obtained from this program from 2001 through 2007. Measured aerosol results include: respirable fractions produced; amounts, nuclide content, and produced particle size distributions and morphology; measurements of volatile fission product species enhanced sorption--enrichment factors onto respirable particles; and, status on determination of the spent fuel ratio, SFR, needed for scaling studies. Emphasis is provided on recent Phase 3 tests using depleted uranium oxide pellets plus non-radioactive fission product dopants in surrogate spent fuel test rodlets, plus the latest surrogate cerium oxide results and aerosol laboratory supporting calibration work. The DUO{sub 2}, CeO{sub 2}, plus fission product dopant aerosol particle results are compared with available historical data. We also provide a status review on continuing preparations for the final Phase 4 in this program, tests using individual short rodlets containing actual spent fuel from U.S. PWR reactors, with both high- and lower-burnup fuel. The source-term data, aerosol results, and program design have been tailored to support and guide follow-on computer modeling of aerosol dispersal hazards and radiological consequence assessments. This spent fuel sabotage, aerosol test program was performed primarily at Sandia National Laboratories, with support provided by both the U.S. Department of Energy and the Nuclear Regulatory Commission. This program has significant input from, and is cooperatively supported and coordinated by both the U.S. and international program participants in Germany, France, and others, as part of the International Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC).
50 J discharge-pumped XeCl laser (1989)

An X-ray preionized XeCl laser with a wide aperture of 10*10 cm/sup 2/ is described. The density for preionization electrons is estimated from an X-ray energy distribution to be greater than 6*10/sup 9/ cm/sup -3/ under operational gas conditions. In high pressure operation at 4500 torr, sufficient preionization has led to successful discharge-breakdown at a low E/N of 6.4*10/sup -17/ V-cm/sup 2/, resulting in a high electrical efficiency of 3.1% with an output energy of 17.6 J. An output energy of 50 J in an 85-ns (FWHM) optical pulse has been extracted from an active volume of about 10:1 for a pulse-forming-line (PFL) voltage of 400 kV. The effects of impedance transformation of a pulse-transmission-line (PTL) following the PFL have been investigated using two types of PTL with output impedances of 0.26 and 0.48 Omega .< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Web Based Cross Language Semantic Plagiarism Detection (2011)

As the Internet help us cross language and cultural border and with different types of translation tools, cross language plagiarism is bound to rise. Besides that, semantic plagiarism, where the student reconstructs the sentence or changes some terms into its corresponding synonyms, also raises concerns in the academic field. Both of this plagiarism is hardly detected due to the difference in their fingerprints. Plagiarism detection tools available are not capable to detect such plagiarism cases. In this research, we propose a new approach in detecting both cross language and semantic plagiarism. We consider Bahasa Melayu as the input language of the submitted document and English as a target language of similar, possibly plagiarised documents. In this system we shorten the query document by utilising fuzzy swarm-based summarisation approach. Our point of view is that using the summary will give us the most important keywords in the document. Input summary documents are translated into English using Google Translate Application Programming Interface (API) before the words are stemmed and the stop words are removed. Tokenized documents are sent to the Google AJAX Search API to detect similar documents throughout the World Wide Web. We integrate the use of Stanford Parser and Word Net to determine the semantic similarity level between the suspected documents with candidate source documents. Stanford parser assigns each terms in the sentence to their corresponding roles such as Nouns, Verbs and Adjectives. Based on these roles, we represent each sentence in a predicate form and similarity is measured based on those predicates using information content value from Word Net taxonomy. Our testing dataset is built up from two sets of Malay documents which are produced based on different plagiarism techniques. The result of our proposed semantic based similarity measurement shows that it can achieve higher precision, recall and F-Measure compared to the conventional Longest Common Subsequence (LCS) approach.
Building Around Inserts: Methods for Fabricating Complex Devices in Stereolithography (2000)

Abstract One of the most common Rapid Prototyping (RP) technologies, the stereolithography apparatus (SLA) fabricates 3-dimensional parts using a layer-based, additive fabrication process by tracing part cross-sections on the top surface of a vat of liquid photopolymer. Typically, usage of the SLA process has been limited to piece parts. We are interested in greatly expanding the application of SLA and other RP technologies by fabricating assemblies of parts as working mechanisms or static, complex structures which we call “live” or “smart” models. To accomplish this, we are investigating methods for building around embedded components, where these components are motors, printed circuit boards, metal bushings, etc. In this paper, we present example prototypes to illustrate the power of building around inserts (embedded components). We report on our problem formulation and a solution approach in the form of a procedure for building around inserts. We believe that our procedure and results lend insight into promising new applications of SLA technology, as well as novel methods of implementing additional functionality into SLA and other RP technologies.
Satellite Micro Anomaly Detection Based on Telemetry Data (2020)

The military requirements of space security defense and space fast response are increasingly urgent. Accurate and effective micro anomaly detection of on-orbit satellites is an important technical way of satellites life cycle health management. Under this military background, the micro anomaly detection of the key components of the satellite is proposed and carried out. In order to solve the problems of low diagnostic accuracy of the traditional Voherra series model in satellite telemetry signal micro anomaly detection, o-Voherra series anomaly detection model for the feature extraction of telemetry data based on the optimized sequence model is proposed. Firstly, the feature of satellite telemetry data is extracted by using the constructed optimized sequence model. Secondly, phase space reconstruction of telemetry data after preprocessing and feature extraction. Finally, the telemetry data micro anomaly detection are realized by the proposed o-Voherra series model. Through the remote sensing data experiment of the key components of the satellite after desensitization, the proposed model can accurately realize the micro anomaly detection of the key components of the satellite.
Role of previous treatment with sulfonylureas in diabetic patients with acute myocardial infarction: results from a nationwide French registry (2004)

In this nationwide registry reflecting real-world practice, the use of sulfonylureas in diabetic patients was not associated with increased in-hospital mortality.
Inhibition of an in Vivo Antigen-Specific IgE Response by Antibodies to CD23 (1993)

Immunoglobulin E (IgE) mediates many allergic responses. CD23 is a 45-kilodalton type II transmembrane glycoprotein expressed in many cell types. It is a low-affinity IgE receptor and interacts specifically with CD21, thereby modulating IgE production by B lymphocytes in vitro. In an in vivo model of an allergen-specific IgE response, administration of a rabbit polyclonal antibody to recombinant human truncated CD23 resulted in up to 90 percent inhibition of ovalbumin-specific IgE synthesis. Both Fabs and intact IgG inhibited IgE production in vitro and in vivo. Thus, CD23 participates in the regulation of IgE synthesis in vivo and so could be important in allergic disease.
Distributed Antenna Array for FANET’s Wireless Links Using Time Modulation (2019)

This article presents a design of a distributed antenna array with time modulation for FANET’s. The array is composed by nine dipole antennas. Each dipole element is mounted in single small aircraft. The design considers the optimization of time modulation sequences for low side lobes, maximum beamforming efficiency and low sidebands. The design process is carried out by using particle swarm optimization. The results reveled the feasibility of using time modulation in distributed antenna arrays for FANET’s.
The Proteome of Community Living Candida albicans Is Differentially Modulated by the Morphologic and Structural Features of the Bacterial Cohabitants (2020)

<i>Candida albicans</i> is a commensal polymorphic and opportunistic fungus, which usually resides as a small community in the oral cavities of a majority of humans. The latter eco-system presents this yeast varied opportunities for mutualistic interactions with other cohabitant oral bacteria, that synergizes its persistence and pathogenicity. Collectively, these communities live within complex plaque biofilms which may adversely affect the oral health and increase the proclivity for oral candidiasis. The proteome of such oral biofilms with myriad interkingdom interactions are largely underexplored. Herein, we employed limma differential expression analysis, and cluster analysis to explore the proteomic interactions of <i>C. albicans</i> biofilms with nine different common oral bacterial species, <i>Aggregatibacter actinomycetemcomitans</i>, <i>Actinomyces naeslundii</i>, <i>Fusobacterium nucleatum</i>, <i>Enterococcus faecalis</i>, <i>Porphyromonas gingivalis</i>, <i>Streptococcus mutants</i>, <i>Streptococcus sanguinis</i>, <i>Streptococcus mitis</i>, and <i>Streptococcus sobrinus</i>. Interestingly, upon exposure of <i>C. albicans</i> biofilms to the foregoing heat-killed bacteria, the proteomes of the fungus associated with cellular respiration, translation, oxidoreductase activity, and ligase activity were significantly altered. Subsequent differential expression and cluster analysis revealed the subtle, yet significant alterations in the <i>C. albicans</i> proteome, particularly on exposure to bacteria with dissimilar cell morphologies, and Gram staining characteristics.
Fabrication and Properties of High-Efficiency Perovskite/PCBM Organic Solar Cells (2015)

PSS/ITO glass substrate by the spin coating method. The performance of the organic solar cells was observed by changing the thickness of CH3NH3PbI3 perovskite. The thickness of a perovskite film can affect the carrier diffusion length in a device that strongly absorbs light in the red spectral region. The short-circuit current density and the power conversion efficiency were 21.9 mA/cm(2) and 11.99 %, respectively, for the sample with 210-nm-thick CH3NH3PbI3 perovskite active layer.
Self-similar singularity of a 1D model for the 3D axisymmetric Euler equations (2015)

We investigate the self-similar singularity of a 1D model for the 3D axisymmetric Euler equations, which approximates the dynamics of the Euler equations on the solid boundary of a cylindrical domain. We prove the existence of a discrete family of self-similar profiles for this model and analyze their far-field properties. The self-similar profiles we find are consistent with direct simulation of the model and enjoy some stability property.
Color invariance (2001)

This paper presents the measurement of colored object reflectance, under different, general assumptions regarding the imaging conditions. We exploit the Gaussian scale-space paradigm for color images to define a framework for the robust measurement of object reflectance from color images. Object reflectance is derived from a physical reflectance model based on the Kubelka-Munk theory for colorant layers. Illumination and geometrical invariant properties are derived from the reflectance model. Invariance and discriminative power of the color invariants is experimentally investigated, showing the invariants to be successful in discounting shadow, illumination, highlights, and noise. Extensive experiments show the different invariants to be highly discriminative, while maintaining invariance properties. The presented framework for color measurement is well-founded in the physics of color as well as in measurement science. Hence, the proposed invariants are considered more adequate for the measurement of invariant color features than existing methods.
Theory of high-field transport of holes in GaAs and InP (1984)

Calculations of the steady-state drift velocity and impact ionization rate of holes in the valence bands of GaAs and InP are presented based on a Monte Carlo simulation with the unique inclusion of a complete band structure (derived using the $\stackrel{\ensuremath{\rightarrow}}{\mathrm{k}}\ifmmode\cdot\else\textperiodcentered\fi{}\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}$ method) and quantum effects such as collision broadening. The results are found to fit the experimental data well throughout an enormous range of applied electric fields. No appreciable anisotropy in the impact ionization rate is obtained theoretically in either material. The impact ionization rate in InP is much lower than in GaAs largely because of the greater density of states in InP and the corresponding higher hole-phonon scattering rate. A possible explanation of the difference in the ratio of electron over hole ionization rates in GaAs and InP is also presented.
The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN (2022)

Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core. Applications from European PCD sites interested in participating in the PCD-CTN were requested. Inclusion criteria consisted of patient numbers, membership of ERN-LUNG PCD Core, use of associated standards of care, experience in PCD and/or CF clinical research, resources to run clinical trials, good clinical practice (GCP) certifications and institutional support. So far, applications from 22 trial sites in 18 European countries have been approved, including >1400 adult and >1600 paediatric individuals with PCD. The PCD-CTN is headed by a coordinating centre and consists of a steering and executive committee, a data safety monitoring board and committees for protocol review, training and standardisation. A strong association with patient organisations and industrial companies are further cornerstones. All participating trial sites agreed on a code of conduct. As CTNs from other diseases have demonstrated successfully, this newly formed PCD-CTN operates to establish evidence-based treatments for this orphan disease and to bring new personalised treatment approaches to patients.
The nymphal‐adult molt of the silverleaf whitefly (Bemisia argentifolii): Timing, regulation, and progress (2002)

The developmental progress of silverleaf whitefly (Bemisia argentifolii) 3rd instars and 4th instar/pharate adults was monitored using a tracking system that had been designed to identify synchronous individuals in another species of whitefly, the greenhouse whitefly, Trialeurodes vaporariorum. When reared on greenbean under conditions of LD 16:8 and a temperature of 26 +/- 2 degrees C, the body depth of 3rd instar SLWFs increased from approximately 0.04 mm (Stage 2) to 0.175-0.2 mm (Stage 7-8) and the body depth of the 4th instar increased from approximately 0.1 mm (Stage 1) to 0.25-0.30 mm (Stage 4-5). The durations of the 3rd instar and the 4th instar/pharate adult were approximately 3 and 7 days, respectively. Examination of coronal sections of 4th instars revealed that adult eye and wing development are initiated during Stage 6, the stage in which an external examination showed that the eye has begun to undergo pigment diffusion. Ecdysteroid titers peaked at approximately 400 fg/ micro g protein during stages 4 through 6A of the 4th instar, i.e., just prior to and upon the initiation of the pharate adult stage. Although adult development is initiated later in the SLWF than in the GHWF (adult eye and wing development begin in Stages 4 and 5, respectively, in GHWFs), the same rapidity of metamorphosis is observed in both species. Within approximately 24 h, the simple bi-layered wing bud developed into a deeply folded wing of nearly adult proportions and within an additional 12-24 h, the nymphal eye and wing bud had been replaced by the well-differentiated eye and wing of the adult whitefly. Our study is the first to describe the regulation, timing, and progress of the nymphal-adult molt and of the structural changes that accompany nymphal-adult metamorphosis in the SLWF.
Strengthen the development of rural human resources in view of promoting the building of a new socialist countryside (2012)

Under the guidance of the concept of scientific development, great changes took place in rural areas. The degree of modernization is increasing. China is a large agricultural country. Farmers in our country at this stage still account for an important part. The development of human resource in rural areas is one of the key to the development of productive forces, but also it is the way to make the country powerful and make the people wealthy. Aiming at the current Situation and existing problems of Chinese rural human resources, this article will discuss the urgency and necessity of the development of human resources in rural areas in the new rural construction, expecting to promote the building of a new socialist countryside.
Distributed allocation of subcarrier, power and bit‐level in multicell orthogonal frequency‐division multiple‐access networks (2014)

The downlink of multicell orthogonal frequency‐division multiple‐access (OFDMA) networks is studied, and the adaptive allocation of spectrum, power and rate is addressed. The authors consider networks with adaptive frequency reuse and discrete‐level rates. Initially, the joint allocation problem is formulated as a centralised non‐linear mixed‐integer program (MIP), which is computationally intractable to solve optimally for practical problem sizes. Then, the capability of the receivers is exploited to estimate the subcarrier channel gains and the joint allocation problem is accordingly decomposed into subproblems, each of which is solved by a different base station with linear complexity. In the proposed iterative algorithm, the base stations perform rate and receiver allocation per subcarrier, with concurrent iterations. A filtering method is introduced to further decrease the algorithm complexity. Furthermore, for benchmarking purposes, the authors transform the original non‐linear MIP to a linear MIP and find the optimal solution by means of standard branch‐and‐cut solvers. The merit of the proposed algorithm is demonstrated with numerical comparisons of its performance against the solutions of the linear MIP and the iterative waterfilling algorithm.
High-power continuous-wave cascade-oscillation at 3 μm and 2 μm with a holmium-doped fiber laser pumped by a fiber Raman laser (2002)

We have successfully used a fiber Raman laser at 1.15 /spl mu/m to enhance the output power of a previously demonstrated Ho/sup 3+/-doped fiber laser that simultaneously oscillates at 3 /spl mu/m and 2 /spl mu/m. To our best knowledge, the output power of 1.6 W ( 840 mW at 3 /spl mu/m and 770 mW at 2 /spl mu/m) obtained in this experiment is higher than any previously reported for a fluoride-glass fiber laser oscillating in the mid-infrared regions.
BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety (2013)

BG-12 may have cytoprotective and anti-inflammatory properties that contribute to its efficacy among patients with RRMS. Findings from phase 2 and 3 studies further support BG-12 as an effective initial therapy. ClinicalTrials.gov ID: NCT00168701; NCT00420212: NCT00451451.