gebhart/patrepeval huggingface dataset:
An MCM/IC timing-driven placement algorithm featuring explicit design space exploration (2002)

A genetic algorithm for building-block placement of MCMs and ICs is presented which simultaneously minimizes layout area and an Elmore-based estimate of the maximum path delay while trying to meet a target aspect ratio. Explicit design space exploration is performed by using a vector-valued, S-dimensional cost function and searching for a set of distinct solutions representing the best tradeoffs of the cost dimensions. Designers can then choose from the output set of feasible solutions. In contrast to existing approaches such as simulated annealing, neither weights nor bounds are needed, thereby eliminating the inherent practical problems of specifying these quantities. Promising results are obtained for various placement problems, including a real-world MCM design.
Scimitar Syndrome (2010)

The surgical treatment of this rare syndrome is safe and effective. The majority of patients were asymptomatic at the follow-up control. There were a relatively high incidence of residual scimitar drainage stenosis that is similar between the 2 reported corrective surgical techniques used.
Cyber Reconnaissance: An Alarm before Cyber Attack (2013)

Today's cyber world is more than the internet. It is interdependent networks containing telecommunication network, embedded system and critical infrastructures. Malicious attacks on critical infrastructure become a major threat to business and government operations. An easy and fast access to network makes business successful and makes sensitive information more vulnerable to cyber thieves. Today's attacker and hacker is skillful and well equipped with various hacking tools can easily exploit a small vulnerability. Reconnaissance is a first phase of cyber-attack and we will study this phase show effective countermeasures. This paper is about the Cyber Reconnaissance and focused on Port Scanning and OS Fingerprinting attack and proposed some easy to use solutions.
Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7 (2017)

The 2525 amino acid SMRT corepressor is an intrinsically disordered hub protein responsible for binding and coordinating the activities of multiple transcription factors and chromatin modifying enzymes. Here we have studied its interaction with HDAC7, a class IIa deacetylase that interacts with the corepressor complex together with the highly active class I deacetylase HDAC3. The binding site of class IIa deacetylases was previously mapped to an approximate 500 amino acid region of SMRT, with recent implication of short glycine-serine-isoleucine (GSI) containing motifs. In order to characterize the interaction in detail, we applied a random library screening approach within this region and obtained a range of stable, soluble SMRT fragments. In agreement with an absence of predicted structural domains, these were characterized as intrinsically disordered by NMR spectroscopy. We identified one of them, comprising residues 1255-1452, as interacting with HDAC7 with micromolar affinity. The binding site was mapped in detail by NMR and confirmed by truncation and alanine mutagenesis. Complementing this with mutational analysis of HDAC7, we show that HDAC7, via its surface zinc ion binding site, binds to a 28 residue stretch in SMRT comprising a GSI motif followed by an alpha helix.
Feed efficiency in laying duck : measurement, genetic variability and correlations with other traits (2010)

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Live demonstration: A compact all-CMOS spatiotemporal compressed sensing video camera (2017)

A compact all-CMOS spatiotemporal compressed sensing (CS) video camera is demonstrated. This CS-based framework [1], implemented on integrated circuits, is able to achieve 20-fold reduction in the readout speed and consumes only 14μW to provide 100 fps videos. Taking advantage of dictionary learning and sparse recovery, this prototype image sensor (127×90 pixels) can reconstruct 100 fps videos from the coded images sampled at 5 fps.
Surface and interface cerium electronic configuration in Ce/Fe (100) (1996)

The cerium electronic configuration of very thin films deposited on Fe(100) has been studied by core level photoemission. In the low-coverage regime ( ⩽ 1 monolayer), cerium atoms are in a trivalent state (4f1 configuration). For larger coverages, cerium atoms exhibit a mixed valent state. This behaviour reflects the valence change of covered cerium atoms at the interface and results from the increase in the hybridization strength for these interface atoms. Owing to an original method, we were able to directly decompose our experimental spectra in two contributions corresponding to the covered ("bulk") and non-covered (surface) atoms.
Anti-α-enolase is a prognostic marker in postoperative lung cancer patients (2015)

Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients.
Enhanced Density-of-States Effective Mass and Strained Endotaxial Nanostructures in Sb-Doped Pb0.97Cd0.03Te Thermoelectric Alloys (2019)

Here we report that CdTe alloying and Sb doping increase the density-of-states effective mass and introduce endotaxial nanostructuring in n-type PbTe, resulting in enhanced thermoelectric performance. A prior theoretical prediction for the presence of resonance states in the conduction band of this system, however, could not be confirmed. An amount of 3 mol % CdTe alloying widens the band gap of PbTe by 50%, leading to enhanced carrier effective mass and Seebeck coefficient. This effect is even more pronounced at high temperatures where the solubility of CdTe increases. At 800 K, when the carrier concentration is the same (4 × 10<sup>19</sup> cm<sup>-3</sup>), the Seebeck coefficient of CdTe-alloyed PbTe is -195 μV K<sup>-1</sup>, 16% higher than that of the Cd-free control sample (-168 μV K<sup>-1</sup>). Sb doping considerably increases the electron concentration of Pb<sub>0.97</sub>Cd<sub>0.03</sub>Te, giving rise to optimized power factors of ∼17 μW cm<sup>-1</sup> K<sup>-2</sup> at 800 K. More importantly, Sb induces strained endotaxial nanostructures evenly distributed in the matrix. These Sb-rich nanostructures account for the ∼40% reduction in the lattice thermal conductivity over the whole measured temperature range. As a result, a maximum ZT of 1.2 is attained at 750 K in 0.5 mol % Sb-doped Pb<sub>0.97</sub>Cd<sub>0.03</sub>Te alloys.
Dissolution Behavior of Different Celluloses (2011)

Celluloses from different origins were dissolved stepwise in N,N-dimethylacetamide/lithium chloride (9% v/w; DMAc/LiCl) with the aim to study the time course of the dissolution process, completeness of dissolution in the dissolved fractions, possible discrimination effects, and differences between the celluloses. Cellulosic pulps from both annual plants and different wood species were analyzed. The obtained fractions were subject to gel permeation chromatography (GPC) with multiple detection to monitor the development of molecular mass distribution (MMD), molecular mass, and recovered mass. The dissolution behavior of accompanying xylans was followed by quantitative analysis of the uronic acids by fluorescence labeling--GPC. The morphological changes at the remaining fibers in the stepwise dissolution were addressed by SEM. The time needed to dissolve completely the cellulosic pulp differed from species to species, mainly between pulps from annual plants and pulps from wood. Annual plants generally needed much longer to dissolve completely. In the beginning of the dissolution, the dissolved fractions of annual plants showed a distinct discrimination effect because they were enriched in hemicellulose. By contrast, wood pulps dissolve fast and without distinct changes in the MMD of the dissolved fractions over time. Bagasse pulp is an exception to the observation for annual plants and rather resembled the behavior of wood celluloses. Prolonged dissolution times, as often practiced in cellulose GPC, do not lead to any improvements regarding the determination of molecular mass, MMD, and recovered mass of injected sample, so that the dissolution times required for reliable GPC analysis can be significantly shortened, which will be important for biorefinery analytics with high numbers of samples.
Enhanced insulin‐like growth factor‐I (IGF‐I) cell association at reduced pH is dependent on IGF binding protein‐3 (IGFBP‐3) interaction (2006)

The cellular microenvironment impacts how signals are transduced by cells and plays a key role in tissue homeostasis. Although pH is generally well regulated, there are a number of situations where acidosis occurs and our work addresses how low pH impacts cell association of insulin-like growth factor-I (IGF-I) in the presence of IGF binding protein-3 (IGFBP-3). We have previously shown that IGF-I cell binding was enhanced in the presence of IGFBP-3 at low pH and now show that this binding is IGFBP-mediated as it is inhibited by Y60L-IGF-I, a mutant with reduced affinity for the IGF receptor (IGF-IR), and unaffected by insulin, which binds but not IGFBPs. Using surface plasmon resonance (SPR), we show that direct binding between IGF-I and IGFBP-3 is pH sensitive. Despite this, the key step in the process appears to be IGFBP-3 cell surface association as Long-R(3)-IGF-I, a mutant with reduced affinity for IGFBPs, shows a similar increase in cell association at pH 5.8 in the presence of IGFBP-3 but does not exhibit pH-dependent binding by SPR. Further, analysis indicates a large increase in low-affinity binding sites for IGF-I in the presence of IGFBP-3 and an elimination of IGF-I enhanced binding when a non-cell associating mutant of IGFBP-3 is added in place of IGFBP-3. That the IGFBP-3-mediated binding localizes IGF-I away from IGF-IR is suggested by triton-solubility testing and indicates additional complexities to IGF-I regulation by IGFBP-3. Identifying the pH-dependent binding partner(s) for IGFBP-3 is a necessary next step in deciphering this process.
ChemInform Abstract: A Highly‐Efficient Palladium‐Catalyzed Aminocarbonylation/SNAr Approach to Dibenzoxazepinones. (2015)

Abstract Various 2‐aminophenols and 2‐bromofluorobenzenes are used as substrates for the convenient one‐pot synthesis of a wide range of dibenzoxazepinones by a palladium‐catalyzed aminocarbonylation/aromatic nucleophilic substitution sequence.
An acyclic polyether dicarboxylic acid ionophore with high selectivity for pH-driven uphill transport of lead(II) ion (1994)

1,2-Bis[2-(o-carboxyphenyloxy)ethoxy]-4-tert-butylbenzene transports PbII ion against its concentration gradient in a liquid membrane system with high selectivity over a variety of monovalent and divalent metal ions.
Th17-Mediated Cross Protection against Pneumococcal Carriage by Vaccination with a Variable Antigen (2017)

Serotype-specific protection against <i>Streptococcus pneumoniae</i> is an important limitation of the current polysaccharide-based vaccines. To prevent serotype replacement, reduce transmission, and limit the emergence of new variants, it is essential to induce broad protection and restrict pneumococcal colonization. In this study, we used a prototype vaccine formulation consisting of lipopolysaccharide (LPS)-detoxified outer membrane vesicles (OMVs) from <i>Salmonella enterica</i> serovar Typhimurium displaying the variable N terminus of PspA (α1α2) for intranasal vaccination, which induced strong Th17 immunity associated with a substantial reduction of pneumococcal colonization. Despite the variable nature of this protein, a common major histocompatibility complex class (MHC-II) epitope was identified, based on <i>in silico</i> prediction combined with <i>ex vivo</i> screening, and was essential for interleukin-17 A (IL-17A)-mediated cross-reactivity and associated with cross protection. Based on 1,352 PspA sequences derived from a pneumococcal carriage cohort, this OMV-based vaccine formulation containing a single α1α2 type was estimated to cover 19.1% of strains, illustrating the potential of Th17-mediated cross protection.
OUTLINE OF THE COMPREHENSIVE AUTOMOBILE TRAFFIC CONTROL PILOT TEST SYSTEM (1979)

In the final phase of the Comprehensive Automobile Traffic Control Project, a pilot system was constructed and put into operation in October 1977. In the pilot area, which covers 28 sq km in southwestern Tokyo, a two-way exchange of digital information occurs between instrumented vehicles and roadside equipment. The driver receives a visual display of routing information that is based on current traffic conditions and other information for safe driving. In order to provide the drivers of noninstrumented vehicles with the routing information, new roadside displays were developed. A roadside radio system, which gives the driver traffic information and provides instructions in an emergency, was also developed. This paper presents an overview of the pilot system and describes the procedure of optimum route finding, the specification of the digital communication link between road and vehicle, and the hardware features of the principal equipment. A preliminary evaluation of the system performance is also described. (Author)
Rational design of p-type thermoelectric PbTe: temperature dependent sodium solubility (2013)

We develop a solid understanding of the temperature-dependent solubility of sodium in p-type PbTe, the most efficient thermoelectric material. The maximum solubility of sodium telluride (NaTe) in PbTe is measured to be 1.4 ± 0.3 at% and the heat of solution is evaluated as 26+19−11 kJ mol−1 that addresses fundamental issues regarding the formation of nano-precipitates.
Les introns auto-catalytiques de groupe i comme modele d'etude du repliement des acides ribonucleiques (1993)

Les introns de groupe i forment un systeme d'etude presque ideal pour le repliement des grandes molecules d'arn en raison de leur propriete auto-catalytique et de l'existence d'un modele tridimensionnel de la structure de leur centre catalytique conserve phylogenetiquement. L'analyse comparative de sequences couplee a la modelisation moleculaire nous ont permis d'identifier plusieurs interactions longue distance essentielles au repliement des ribozymes dans leur conformation active. Ces interactions, localisees dans les regions peripheriques non universellement conservees des ribozymes de groupe i, ont ete caracterisees fonctionnellement en changeant les nucleotides impliques et en etudiant l'activite et le comportement biophysico-chimique des molecules resultantes. Nos resultats indiquent que les regions peripheriques, souvent tres dissemblables structuralement, se replient differemment pour conduire neanmoins a un repliement identique du cur catalytique. Par ailleurs, l'etude specifique du processus d'inactivation/depliement d'un ribozyme de groupe i a revele que l'assemblage tridimensionnel se fait en une etape unique tres cooperative, gouvernee par quelques interactions tertiaires specifiques. Elle nous a conduit a developper une methode permettant de calculer aisement la contribution energetique d'une interaction tertiaire individuelle a la stabilite globale d'un ribozyme. Cette methode a ete utilisee pour demontrer l'existence d'une nouvelle interaction tertiaire formee entre une boucle a quatre nucleotides de type gnra et une double helice d'arn. Ce nouveau motif tertiaire probablement universel peut etre remplace par un autre motif d'arn de type pseudo-nud, structuralement tres different mais fonctionnellement equivalent
Novel Integration of Geopolymer Pavers, Silva Cells and Poplar Trees for In-Situ Treatment of Car-Wash Wastewater (2020)

This paper presents an eco-friendly, low-impact development (LID) approach, developed and implemented at a car wash site for a cleaner and greener environment. In this approach, the contaminated water discharged after car washing is treated as it is directed through an engineered, ecology-based water-management design. The design involves poplar (Populus deltoides) trees, Silva Cells®, and Fly-ash based Geopolymer concrete pavers working collectively to minimize the percolation of contaminants into the soil. In this novel system, each component has a vital role. For instance, the extensive roots of the poplar trees enable water filtration owing to phytoremediation effect; while the Silva Cells® promote stormwater management, planting of poplar trees and serve as a foundation for paver blocks. Lastly, the paver blocks made from industrial waste allow it to withstand urban load and infiltrate water runoff, thereby reducing runoff quantities. To evaluate the efficacy of contaminant uptake by this system, pH, electrical conductivity and turbidity, which are indicators of water quality levels, were monitored pre- and post-treatment. The percentage change in total dissolved solids indicates the potential of this treatment system for effective treatment of the contaminated car wash water.
TMIC-18. IMPACT OF HFE MUTATION ON VIABILITY IN MACROPHAGES EXPOSED TO GLIOBLASTOMA EXOSOMES (2018)

In Glioblastoma (GBM), the tumor microenvironment is critical to cancer development and progression. Glioblastoma Extracellular Vesicles (GBM-EVs) have been shown to promote a tumor-supporting phenotype in macrophages, leading to surrounding immunosuppression and enhanced tumor growth. Microglia and macrophages contribute to iron homeostasis, essential for cellular energy production in rapidly dividing cells. The HFE mutation is associated with altered cellular iron homeostasis. It is the most common autosomal recessive polymorphism found in Caucasians and may be linked to worse patient prognosis in GBM. Our lab showed that HFE mutation confers phenotypic differences between HFE and wild-type (WT) macrophages, with HFE macrophages displaying increased migration and phagocytosis. How these phenotypic differences may present in response to GBM exosomes has not yet been explored. Primary macrophage cultures isolated from bone marrow of WT and HFE mutant knock-in mice were exposed to exosomes from different patient-derived cancer stem cells. Significant differences in macrophage viability 24 hours after exosome exposure were observed in response to GBM exosomes (p= 0.001). When exposed to GBM exosomes, WT macrophage viability consistently decreased while the viability of macrophages with the HFE mutation increased. There was no significant difference between the two genotype macrophage groups when exposed to U87 exosomes, supporting that the stem cells are modulating macrophage phenotype. These data suggest that genotypic differences in iron handling pay a critical role in macrophage response to GBM exosomes and may be responsible for differences seen in disease severity in patients with HFE mutations.
Demonstration of integrating post-thinning clean and TSV exposure recess etch into a wafer backside thinning process (2012)

The development of 3D-SIC technology has been requiring more delicate backside processing with increasing complexity and process requirements. As one of the key enabling process steps, wafer backside thinning must also evolve to satisfy the emerging demands. In addition to extreme wafer thickness control, the process requirements has also been extended into contamination control and cost reduction aspects, etc. In this work, we demonstrated a novel wafer backside thinning process integrated with post thinning clean and TSVs exposure recess etch in the context of imec's 300 mm wafer backside integration scheme. We expected that implementation of this process in the production line could dramatically simplify and eventually reduce the totally cost of wafer backside processing for 3D-SIC.
Etude comparative in vitro de l'activité antioxydante d'une nouvelle molécule à groupe thiol, la nacystelyn, vis-à-vis de trois espèces réactives dérivées de l'oxygène (1996)

info:eu-repo/semantics/published
ChemInform Abstract: Regioselective One‐Pot Protection and Protection—Glycosylation of Carbohydrates (2011)

Abstract Review: 36 refs.
Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury (2012)

Reestablishing homeostasis after tissue damage depends on the proper organization of stem cells and their progeny, though the repair mechanisms are unclear. The mammalian intestinal epithelium is well suited to approach this problem, as it is composed of well-delineated units called crypts of Lieberkühn. We found that Wnt5a, a noncanonical Wnt ligand, was required for crypt regeneration after injury in mice. Unlike controls, Wnt5a-deficient mice maintained an expanded population of proliferative epithelial cells in the wound. We used an in vitro system to enrich for intestinal epithelial stem cells to discover that Wnt5a inhibited proliferation of these cells. Surprisingly, the effects of Wnt5a were mediated by activation of transforming growth factor-β (TGF-β) signaling. These findings suggest a Wnt5a-dependent mechanism for forming new crypt units to reestablish homeostasis.
Future mobile network management with attractor selection (2012)

Several task forces have been working on how to design the future Internet and it is high time for research work to move a step forward to networks on a large scale. In this paper, we propose a future mobile network architecture on a combination of OpenFlow and the attractor selection method to achieve scalability and energy conservation. In addition, we propose novel approaches to wireless network management by extending the attractor selection mechanism in route calculation and signaling cost for energy conservation. First, each mobile node selects the best suited interfaces in accordance with instantaneous live traffic volume. Then, network devices select the best cluster to join to reduce handover signaling cost. Through autonomous decision of each mobile node and network device, the whole wireless network can be managed in an energy efficient and robust manner.
Reassessment of the role of CD8+ T cells in the induction of allograft tolerance by donor-specific blood transfusion (1999)

Donor-specific allograft tolerance can be induced in adult rats by pregraft donor-specific blood transfusion (DST). We have previously shown that DST elicits in recipients the expansion of a donor-specific CD8+ T cell clone displaying the Vbeta18-Dbeta1-Jbeta2.7 TCR rearrangement, which rapidly infiltrates allografts after transplantation, suggesting a regulatory function for this clone in DST-induced tolerance. In this study, recipients were pretreated before grafting, using an anti-CD8 monoclonal antibody to deplete CD8+ T cells. CD8 depletion before DST and transplantation abrogated allograft tolerance, and the CD8+ T cell clone was absent from allografts. These effects were not observed when CD8 depletion was performed after DST but before transplantation. We conclude that CD8+ T cells play a role in the induction of allograft tolerance by DST.