gebhart/patrepeval huggingface dataset:
MODULATION OF [CIS-DIAMINEDICHLOROPLATINUM(II) HYPERTHERMIA] THERAPY BY INHIBITORS OF ARACHIDONIC-ACID METABOLISM (1994)

Previous studies have shown that hyperthermia is an effective modulator of cis-diamminedichloroplatinum(II) (CDDP) cytotoxicity. We have examined the potential of inhibitors of the arachidonic acid metabolism to increase the antitumor activity of CDDP and hyperthermia. Sulindac and diflunisal are cyclooxygenase inhibiting non-steroidal anti-inflammatory drugs (NSAIDS) and phenidone is a lipoxygenase inhibitor. Using the FSaIIC in vivo-in vitro excision assay, neither five daily injections of sulindac nor diflunisal added to the killing of FSaIIC cells achieved by one injection of CDDP at normal temperature. When the i.p. injection of CDDP and the NSAIDS were followed immediately by hyperthermia treatment to the tumor bearing limb at 43-degrees-C for 30 min, the cell killing achieved was increased by 2-3-fold by diflunisal over the dose range of CDDP examined but was unaffected by sulindac. Phenidone did not alter the cell killing achieved by CDDP at normal temperature or when the CDDP was followed by local hyperthermia, but use of a combination of sulindac or diflunisal plus phenidone increased the cell killing achieved by 2-10-fold when used with local hyperthermia over the dose range of CDDP tested. In tumor growth delay (TGD) studies, addition of five daily injections of sulindac, diflunisal or phenidone did not increase the TGD achieved by CDDP at normal temperature and neither diflunisal nor phenidone markedly increased the TGD produced by CDDP in conjunction with local hyperthermia, but the administration of sulindac resulted in about a 3-fold increase in TGD as did use of a combination of diflunisal or sulindac plus phenidone. These results indicate that inhibitors of arachidonic acid metabolism can increase the cell killing and the tumor growth delay produced by CDDP plus local hyperthermia.
Triple correlation on groups (1992)

The triple correlation of an arbitrary function on the real line is the integral of the product of that function with two independently shifted copies of itself. Triple correlation methods are frequently used in signal processing for treating signals that are corrupted by additive Gaussian noise; in particular, triple correlation techniques perform well when multiple observations of the signal are available and the signal may be translating in between the observations, e.g., a sequence of images of an object translating on a noisy background. What makes the triple correlation particularly suitable for such tasks are three properties: (1) it is invariant under translation of the underlying signal; (2) it is insensitive to additive Gaussian noise; and (3) it retains most of the phase information in the underlying signal. This thesis investigates whether the properties (1)-(3) of the triple correlation extend to functions on arbitrary locally compact groups, in particular the groups of rotations and rigid motions of euclidean space that arise in computer vision and signal processing.
After defining triple correlation for any locally compact group by using the group's left-invariant Haar measure, it is easily shown that the resulting object is invariant under left translation of the underlying function and insensitive to additive Gaussian noise. What is more interesting is the question of uniqueness: when two functions have the same triple correlation, how are the functions related? Our results show that for most cases of practical interest, the triple correlation of a function on an abstract group uniquely identifies that function up to a group translation. We show how our results utilize the duality theorems of Pontryagin, Tannaka-Krein, Iwahori-Sugiura, and Tatsuuma. We also develop explicit algorithms for recovering bandlimited functions from the triple correlation on the rotation groups in two and three dimensions. Finally, we describe the formal relationship between our triple correlation analysis and the Tauberian theorem of N. Wiener concerning the span of translates of a function.
Inorganic polyphosphate in mammals: where's Wally? (2020)

Inorganic polyphosphate (polyP) is a ubiquitous polymer of tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. In prokaryotes and lower eukaryotes, both the presence of polyP and of the biosynthetic pathway that leads to its synthesis are well-documented. However, in mammals, polyP is more elusive. Firstly, the mammalian enzyme responsible for the synthesis of this linear biopolymer is unknown. Secondly, the low sensitivity and specificity of available polyP detection methods make it difficult to confidently ascertain polyP presence in mammalian cells, since in higher eukaryotes, polyP exists in lower amounts than in yeast or bacteria. Despite this, polyP has been given a remarkably large number of functions in mammals. In this review, we discuss some of the proposed functions of polyP in mammals, the limitations of the current detection methods and the urgent need to understand how this polymer is synthesized.
Pain drawing evaluation–the problem with the clinically biased surgeon: Intra- and interobserver agreement in 50 cases related to clinical bias (1998)

To assess whether the clinical knowledge of the treating surgeon had any effect on the reliability of the pain-drawing evaluation, drawings from 50 low-back pain patients were evaluated by the treating surgeon and by three colleagues who had no clinical knowledge of the patient. The evaluation was repeated after 10 days. The treating surgeons were also blinded to clinical data. The kappa value in the evaluation when the surgeon had clinical knowledge of the patient was lower (0.29 (95% Cl 0.13-0.45)) than the kappa value in the evaluations made without clinical knowledge (0.60 (Cl 0.45-0.75)). The differences observed in interobserver reliability between open and blind evaluations suggest that clinical knowledge of a patient influences the evaluation of the pain drawings.
Deep image with non-degenerated two-photon excitation (Conference Presentation) (2018)

In non-degenerate 2-photon excitation (ND-2PE) microscopy, a fluorophore simultaneously absorbs two photons of different energies. We performed a ND-2PE study of fluorescent proteins and synthetic dyes (eg.eGFP, FITC, and etc.) continuously varying energies and numbers of both photons to create two-dimensional map of fluorescence landscapes. By using the best photon energy combination from our two-dimensional map, we found an increase in detected fluorescent image brightness with ND-2PE as we imaged cortical neurons labeled with enhanced green fluorescent protein (eGFP). It should be noted that the photons corresponding to longer wavelength will penetrate deeper into the tissue at reduced scattering. Additionally, using non-overlapping spatial modes carrying the photons at different energies will significantly reduce out of focus fluorescence from the large number of low energy photons, and by a proper choice of the number of high energy photons the ND-2PE fluorescence can be obtained from deep tissue. Experimentally, we strategically displaced two laser beams until they reached the sample plane such that the unwanted background in the excitation beam path was suppressed. In contrast, these two pump beams were well overlapped at focus which still produced sufficient number fluorescence photons for detection. In our experiment, the temporal alignment was achieved with optical delay line in the optical path of IR beam. With this technique we demonstrated experimentally that ND-2PE with side-by-side beams provided a better signal to background ratio in the scattering phantom as compared with D-2PE. The excitation volume of ND-2PE with side-by-side beam was also investigated and determined to be comparable in size with that of the D-2PE.
Neue Perspektiven auf die politische Ökonomie von Karl Marx und Friedrich Engels (2019)

Following WWI, the Communists (KPD) who split away from the Social ists competed with them in extending "counterinstitutionalization." In 1927, the Marxist Workers School (MASCH: Marxistische Arbeiterschule) was founded in most of Germany's large cities as a party institution that offered courses for those interested in Marxism and the frontier of culture and sci ence. At its height, the number of the schools was thirty. It is said that in 1930-1931, a single year, the MASCH Berlin alone offered 400 courses ranging from politics and economics, to culture, medicine, and sexual educa tion. After several decades, during the age of MarxRenaissance and around 1970, MASCH textbooks were reprinted and read by young leftist students in West Germany. Amalgamated with the waves of avantgarde intellectuals, MASCH represented the peak of Marxist counterinstitutionalization. Beside the veteran popularizers such as Duncker, young radical scholars such as Karl August Wittfogel collaborated with MASCH.
Preparation and Characterization of Nd-Doped Ti/SnO<sub>2</sub>-Sb<sub>2</sub>O<sub>5</sub> Electro-Catalytic Electrodes Used for Reactive Brilliant Red X-3B Wastewater Treatment (2012)

The best catalytic capacity of Nd-doped Ti/SnO2-Sb2O5 electrodes was obtained by sol-gel preparation. Nd-doped Ti/SnO2-Sb2O5 coating was characterized using technique such as scanning electron microscopy (SEM), and X-ray diffraction (XRD). Nd-doped electrode fragments looks smaller, more compact and more uniform than undoped electrode through SEM. The crystal cell’s average diameter of Nd-doped electrodes was 3.48nm through XRD. BOD5/COD of Reactive Brilliant Red X-3B increased 200% under optimum conditions after 1h electrolysis. Instantaneous current efficiency (ICE) was 51.15 % in first 40 min, 35.73 % in first 60 min. In the first 40 minutes of electrolysis process, COD of Reactive Brilliant Red X-3B changes conformed to the pseudo first-order kinetic equation. Electrical Properties Tests showed that the oxygen evolution potential values of Nd-doped electrodes were higher than the undoped electrodes in various media.
Degassing Polymer Melts with Co-Rotating Twin Screw Extruders (2007)

No AccessCo-Rotating Twin-Screw ExtruderNov 2007Degassing Polymer Melts with Co-Rotating Twin Screw ExtrudersFrank LechnerFrank Lechnerhttps://doi.org/10.3139/9783446433410.010SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 181-201Print ISBN: 978-3-446-41372-6eISBN: 978-3-446-43341-0 Copyright & Permissions© 2008 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A multi-pronged approach to benchmark characterization (2010)

Understanding the behavior of current and future workloads is key for designers of future computer systems. If target workload characteristics are available, computer designers can use this information to optimize the system. This can lead to a chicken-and-egg problem: how does one characterize application behavior for an architecture that is a moving target and for which sophisticated modeling tools do not yet exist? We present a multi-pronged approach to benchmark characterization early in the design cycle. We collect statistics from multiple sources and combine them to create a comprehensive view of application behavior. We assume a fixed part of the system (service core) and a “to-be-designed” part that will gradually be developed under the measurements taken on the fixed part. Data are collected from measurements taken on existing hardware and statistics are obtained via emulation tools. These are supplemented with statistics extracted from traces and ILP information generated by the compiler. Although the motivation for this work is the classification of workloads for an embedded, reconfigurable, parallel architecture, the methodology can easily be adapted to other platforms.
The systemic administration of intravenous melphalan. (1988)

Melphalan (L-phenylalanine mustard) is a bifunctional alkylating agent that is commonly administered orally to treat a wide variety of malignancies, including cancers of the breast and ovary, as well as multiple myeloma. Although commercially available in Europe and Canada, intravenous (IV) melphalan remains investigational in the United States. The role of IV melphalan in cancer chemotherapy is not well defined, despite its manageable toxicity and higher and more predictable blood levels following IV administration compared with oral administration. In addition, unlike oral melphalan, an extensive phase I evaluation of IV melphalan has not been undertaken. At lower doses (eg, 30 to 70 mg/m2), both as a single agent and in combination, the activity of IV melphalan has been evaluated in only a limited number of diseases. However, striking activity has been observed in previously untreated patients with rhabdomyosarcoma, a disease not generally considered responsive to alkylating agents. When administered at high doses (greater than 140 mg/m2) requiring bone marrow reinfusion, melphalan effects a high response rate (but no improvement in survival) in a variety of nonhematologic tumor types, including resistant tumors such as melanoma and colon carcinoma. In contrast, in poor-prognosis patients with non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, or neuroblastoma, high-dose melphalan-containing regimens have yielded both high response rates and improved survival, despite considerable toxicity. Additional clinical trials will be necessary to define the spectrum of activity of lower doses of IV melphalan and to define subgroups of patients most likely to benefit from high-dose melphalan.
Abstract 14952: Lysosomal Regulation of Calcium and Iron Homeostasis and Ferroptosis in Mouse Cardiomyocytes (2022)

Background: Lysosomes are specific organelles that contain various digestive enzymes and also store both iron (Fe) and calcium (Ca). However, it is not known whether cytosolic and mitochondrial Fe and Ca handling and ferroptosis are modulated by lysosomal dysfunction. We aimed to evaluate the interaction between lysosomal, mitochondrial and cytosolic Ca and Fe dynamics and its relevance to cardiomyocyte function and ferroptosis. Methods: Left ventricular myocytes were enzymatically isolated from mouse hearts. Cytosolic Ca i was imaged using fluo-4-AM. Cytosolic Fe was determined with Phen green while mitochondrial Fe was measured using rhodamine B-[(1,10-phenanthroline-5-yl)-aminocarbonyl]benzyl ester (RPA). Mitochondrial membrane potential (Δ Ψ m ) was monitored by TMRM. Ferroptosis was analyzed using the Live/Dead cell viability assay. Results: Treatment with nicotinic acid dinucleotide phosphate (NAADP-AM 50 nM), an agonist of the two pore channel in the lysosomal membrane, increased the aptitude of the Ca i transient (1.94 ± 0.09 to 2.41 ± 0.14, n = 12, p &lt; 0.05) and induced spontaneous Ca i waves. Diastolic Ca i became elevated (1.00 to 1.30 ± 0.10, n = 12, p &lt; 0.05) in intact myocytes. Elevation of basal Ca i level and an increase in spontaneous Ca i wave amplitude and frequency were confirmed in saponin-permeabilized myocytes. NAADP also increased the level of cytosolic Fe. These results suggest both Ca and Fe are released from lysosomes into the cytosol by NAADP. Our previous studies have shown that mitochondrial Fe uptake is essential for Fe overload-induced ferroptosis in cardiac myocytes. Therefore, we further assessed how lysosome function affects mitochondrial Fe loading and induction of ferroptosis. We found that NAAPD treatment resulted in an elevation of mitochondrial Fe levels (by 28.4 ± 3.5 %, n=23, p &lt;0.05), depolarization of Δ Ψ m as well as resulted in an increased sensitivity to Fe overload-induced ferroptosis. Similar results were observed using GPN that causes selective disruption of lysosomes. Conclusions: Lysosomal dysfunction may contribute to mishandling of Ca and Fe in myocytes and promote the occurrence of ferroptosis. A lysosomal storage disorder mouse model ( i.e. RagA/B KO) will be assessed in future studies.
Predicting Survival, Length of Stay, and Cost in the Surgical Intensive Care Unit (1998)

Because ICISS is both more accurate and much less expensive to calculate than APACHE II score, ICISS should replace APACHE II score as the standard risk stratification tool in surgical ICUs.
Kinetics of Magnesium Deposition and Stripping from Non-Aqueous Electrolytes (2017)

Three previously reported non-aqueous electrolyte solutions were investigated electrochemically to determine the kinetics of the Mg deposition–dissolution process as well as the resulting morphology after Mg-ion reduction onto a bulk metal working electrode. Of the solutions examined, the 1.2 M ((CF3)2CH3)COMgCl and 0.2 M AlCl3 in THF solution (F6-t-butoxide) shows the lowest Tafel slope of 26.4 mV/dec, followed by 0.5 M RPhOMgCl and 0.25 M AlCl3 where R = 2,4,6-Me3 in THF (2,4,6-Me3 phenolate, 32.1 mV/dec) and 0.4 M PhMgCl and 0.2 M AlCl3 in THF (APC, 56.2 mV/dec). The fluorinated alkoxide results in complete magnesium coverage of the working electrode, with the metal growing along the [100] direction, orthogonal to the electrode surface. This behavior is contrary to the aromatic-based electrolyte solutions, which show less crystalline Mg deposits and incomplete surface coverage. Through a combination of electron microscopy, X-ray diffraction, and electrochemical methods, we show that this sporadic deposition, in addition to lower solution conductivities, drastically hinders the current density observed for phenolate and APC electrolytes. Electrochemical impedance spectroscopy demonstrates that the largest resistance originates at the platinum–magnesium interface and the solution resistance itself, rather than the actual charge transfer between the electrode and magnesium ions in solution. The facile kinetics of Mg-deposition, along with a strong dependence on surface crystallinity and coverage, suggests the importance of measuring solution conductivity in addition to fully characterizing the resulting magnesium deposits under chronopotentiometric conditions.
The Detection of Bacteria and Bacterial Biofilms in Punctal Plug Holes (2001)

Careful observation of patients with punctal plugs is important. If material accumulates in or on a punctal plug, it may contain bacteria and may form a bacterial biofilm. In these cases, replacement of the plug, clearing of the hole, or an alternative treatment should be considered.
Glucose transporter 1 suppresses melanocortin 4 receptor activity (2016)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
3P2-H05 Fabrication of Hydrogel Hollow Microfiber for Microbe Cultivation(Nano/Micro Fluid System) (2014)

Metabolite utilization is highly demanded for sustainable society. However there are many cases when cultivating a microorganism to be contaminated by other microorganisms in open-environment and that particular one cannot be survive. That is why, it is necessary to establish a way to avoid those affection but at the same time make them absorb nutrients to live and metabolize. In tissue engineering, cell-laden microfibers which grow biological cell within the fiber has a high profile. One approach is to structure fiber with calcium alginate. In order to apply this technique in microorganisms' cultivation, we proposed a process to fabricate hollow microfiber in this study. We also experimentally verified that porous surfaced hollow microfiber worked as protection for inside microorganisms from germ. Our results show that this way has potential to culture microorganisms massively in open-environment.
Hyperlipidemia Is a Risk Factor of Adhesive Capsulitis: Real-World Evidence Using the Taiwanese National Health Insurance Research Database (2021)

Patients with hyperlipidemia had a 1.5-fold higher risk of adhesive capsulitis than did healthy controls. Statin use did not provide protection against adhesive capsulitis in patients with hyperlipidemia.
ChemInform Abstract: LABILE 1,10‐PHENANTHROLINE N‐OXIDE COMPLEXES WITH TIN(II) AND ‐(IV) HALIDES (1980)

Abstract Die durch Umsetzung einer methanolischen Lösung von Sn(II)‐halogeniden oder einer Chloroformlösung von Sn(IV)‐halogeniden mit Phenanthrolin‐N‐oxid in Ethanol gebildeten Halogeno‐phenanthrolin‐N‐oxid‐Sn(II)‐ oder ‐Sn(IV)‐Addukte reagieren schnell weiter mit der Reaktionslösung und sind daher äußerst schwierig zu isolieren.
Poly(2,3-dihexylthieno[3,4-b]pyrazine) via GRIM Polymerization: Simple Preparation of a Solution Processable, Low-Band-Gap Conjugated Polymer (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPoly(2,3-dihexylthieno[3,4-b]pyrazine) via GRIM Polymerization: Simple Preparation of a Solution Processable, Low-Band-Gap Conjugated PolymerLi Wen†, Benjamin C. Duck‡, Paul C. Dastoor‡, and Seth C. Rasmussen*†View Author Information Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, and Centre for Organic Electronics, University of Newcastle, Callaghan NSW 2308, Australia* Corresponding author. E-mail: [email protected]†North Dakota State University.‡University of Newcastle.Cite this: Macromolecules 2008, 41, 13, 4576–4578Publication Date (Web):June 3, 2008Publication History Received12 May 2008Revised14 May 2008Published online3 June 2008Published inissue 1 July 2008https://pubs.acs.org/doi/10.1021/ma801057shttps://doi.org/10.1021/ma801057srapid-communicationACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views2133Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Energy,Materials,Polymerization,Thin films,Two dimensional materials Get e-Alerts
A Novel Translocation InvolvingRUNX1andHOXAGene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22) (2013)

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.