gebhart/patrepeval huggingface dataset:
Influence of Grip Mass on Driving Performance (2020)

The purpose of the study was to determine the influence of grip mass on driver clubhead kinematics at impact as well as the resulting kinematics of the golf ball. Three club mass conditions (275, 325, and 375 g) were tested by 40 experienced golfers (handicap = 7.5 &plusmn; 5.3) representing a range of clubhead speeds (36 to 54 m/s). Each participant executed 12 drives per condition using matched grips and shafts and a single clubhead. Club mass was modified by inserting 50 g and 100 g into the grips of the two heavier conditions. The heaviest condition was associated with the slowest clubhead speed (p = 0.018) and highest vertical launch (p = 0.002), which resulted in no net influence on driving distance (p = 0.91). Lateral dispersion was greatest with the 325 g condition (p = 0.017), as was horizontal impact spot variability on the driver face (p = 0.031). Findings at the individual golfer level were not reliable enough to suggest that grip mass could be effectively used in a fitting environment to either shift ball flight tendencies or improve consistency.
Fullerene‐like Mo(W)1−xRexS2 Nanoparticles (2008)

Inorganic fullerene-like (IF) Mo(1-x)Re(x)S(2) and W(1-x)Re(x)S(2) nanoparticles have been synthesized by a gas-phase reaction involving the respective metal halides with H(2)S. The IF-Mo(W)(1-x)Re(x)S(2) nanoparticles, containing up to 5 % Re, were characterized by a variety of experimental techniques. Analyses of the X-ray powder diffraction and different electron microscopy techniques show that the Re is doped in the MoS(2) host lattice. Interestingly, Re-doped MoS(2) nanotubes are present as well, although in small quantities ( approximately 5 %). XPS results confirm the nanoparticles to be more n-type arising from the effect of Re doping. Additionally, density-functional tight-binding (DFTB) calculations support the observed n-type behavior.
Divalent metal transporter 1 (2005)

In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1). DMT1 functions in transport of ferrous iron, and some, but not all divalent metal ions across the plasma membrane and/or out of the endosomal compartment. DMT1 mRNA has been found in every cell type in which it has been sought and its structure is highly conserved in evolution with similar proteins expressed in plants, insects, microorganisms and vertebrate animals. Rodents with defects in iron absorption and utilization were identified long before it was determined that the defect was due to a single nucleotide mutation in DMT1. Study of these animals reveals that transport of iron and other divalent metal ions by DMT1 is pH dependent, but the exact manner in which pH exerts its effect is unknown. The structure of the DMT1 gene is complex. Alternative usage of 3' exons, results in forms with and without iron responsive elements (IREs), while alternative usage of 5' exons and less well defined products of alternative splicing results in an array of isoforms with incompletely defined function. Expression of some isoforms is tissue specific and appears to affect subcellular targeting of the protein. At least one signal for DMT1 expression appears to be intracellular iron status, however, other, as yet undefined signals may also contribute to DMT1 expression. Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells. The importance of DMT1 function at the level of the whole organism and the individual cell and mechanisms of its regulation on a molecular scale are only beginning to be understood; an appreciation of these process will lead to an understanding of the role of iron in various cellular processes and improved treatments for both anemia and iron-overload.
Influence of Interferon-γ Deficiency in Immune Tolerance Induced by Male Islet Transplantation (2011)

Deficiency of IFN-γ does not have influence on the result of male skin graft and male islet transplantation. Conclusively, male islet transplantation induced T cell tolerance is not dependent on the presence of IFN-γ.
Cobalt-59 nuclear magnetic resonance studies on hexakis(phosphite)-cobalt(III) complexes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCobalt-59 nuclear magnetic resonance studies on hexakis(phosphite)-cobalt(III) complexesR. Weiss and J. G. VerkadeCite this: Inorg. Chem. 1979, 18, 2, 529–530Publication Date (Print):February 1, 1979Publication History Published online1 May 2002Published inissue 1 February 1979https://pubs.acs.org/doi/10.1021/ic50192a074https://doi.org/10.1021/ic50192a074research-articleACS PublicationsRequest reuse permissionsArticle Views27Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data from ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody–Drug Conjugate Treatment (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Mesothelin (MSLN) is frequently overexpressed in pancreatic and ovarian cancers, making it a potential drug target. We performed an &lt;sup&gt;89&lt;/sup&gt;Zr-PET imaging study with MMOT0530A, a MSLN antibody, in conjunction with a phase I study with the antibody–drug conjugate DMOT4039A, containing MMOT0530A bound to MMAE. The aim was to study antibody tumor uptake, whole-body distribution, and relation between uptake, response to treatment, and MSLN expression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Before DMOT4039A treatment, patients received 37 MBq &lt;sup&gt;89&lt;/sup&gt;Zr-MMOT0530A followed by PET/CT imaging 2, 4, and 7 days postinjection. Tracer uptake was expressed as standardized uptake value (SUV). MSLN expression was determined with immunohistochemistry (IHC) on archival tumor tissue.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Eleven patients were included, 7 with pancreatic and 4 with ovarian cancer. IHC MSLN expression varied from absent to strong. Suitable tracer antibody dose was 10 mg MMOT0530A and optimal imaging time was 4 and 7 days postinjection. Tumor tracer uptake occurred in 37 lesions with mean SUV&lt;sub&gt;max&lt;/sub&gt; of 13.1 (±7.5) on PET 4 days postinjection, with 11.5 (±7.5) in (&lt;i&gt;N&lt;/i&gt; = 17) pancreatic and 14.5 (±8.7) in (&lt;i&gt;N&lt;/i&gt; = 20) ovarian cancer lesions. Within patients, a mean 2.4-fold (±1.10) difference in uptake between tumor lesions existed. Uptake in blood, liver, kidneys, spleen, and intestine reflected normal antibody distribution. Tracer tumor uptake was correlated to IHC. Best response to DMOT4039A was partial response in one patient.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; With &lt;sup&gt;89&lt;/sup&gt;Zr-MMOT0530A-PET, pancreatic and ovarian cancer lesions as well as antibody biodistribution could be visualized. This technique can potentially guide individualized antibody-based treatment. &lt;i&gt;Clin Cancer Res; 22(7); 1642–52. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Neuroprotection by the Selective Cyclooxygenase-2 Inhibitor SC-236 Results in Improvements in Behavioral Deficits Induced by Reversible Spinal Cord Ischemia (2001)

The present study suggests that COX-2 plays an important role in the ischemic cascade of events that translate into ischemia-induced behavioral deficits and furthermore that selective COX-2 inhibitors may be useful in the treatment of ischemic stroke to improve behavioral functions.
Deep-Red/Near-Infrared Turn-On Fluorescence Probes for Aldehyde Dehydrogenase 1A1 in Cancer Stem Cells (2021)

Accumulating evidence supports that cancer stem cells (CSCs) are responsible for cancer proliferation, metastasis, and therapy resistance; therefore, an effective strategy to identify and isolate CSCs is required urgently. Because of their low invasiveness and high signal/noise ratio, "turn-on" fluorescence probes working in the deep-red/near-infrared (DR/NIR) region are one of the most attractive yet undeveloped tools for CSC detection. Herein, we report DR/NIR turn-on fluorescence probes, <b>CS5-A</b> and <b>CS7-A</b>, targeted to aldehyde dehydrogenase 1A1 as an intracellular CSC marker. In contrast to the conventional "always-on" green-fluorescent ALDEFLUOR, we succeeded in generating high-contrast (signal/noise ratio > 8.3) and wash-free in vitro CSC imaging with the DR probe <b>C5S-A</b>. This probe can facilitate CSC isolation with minimal contamination by autofluorescence from other tissues through fluorescence-activated cell sorting. Furthermore, the NIR absorbance/emission and turn-on properties of <b>C7S-A</b> allow simple and rapid CSC detection in vivo within 15 min.
P2‐177: Accumulation of misfolded and hyperphosphorylated tau protein in transgenic rat cortical neurons is underlying cause of increased sensitivity to nitrosative stress (2008)

Alzheimer's disease (AD) is a major cause of memory impairment and cognitive decline in adulthood. Increased accumulation of aberrant proteins and formation of high molecular complexes of tau proteins within the neurons are typical features of the disease. Our aim was to investigate molecular mechanisms leading to generation of toxic tau species and formation of tau protein complexes within the neurons. Human full length (1–441, 4R – t40) and truncated tau (151–391, 4R) were cloned, isolated from bacteria and purified by ion-exchange chromatography followed by size-exclusion gel filtration. The proteins were stored under argon atmosphere in order to prevent oxidation. 3-morpholinosydnonimine (Sin-1) was used for in vitro nitration of recombinant tau proteins. Oligomerization of tau molecules was detected by western blotting with specific anti-tau mAb DC25. The expression of truncated misfolded tau protein in primary neurons (derived from 18 days old embryos) was determined in isolated neurons from transgenic rats (Zilka et al. 2006). We have defined intracellular distribution of tau proteins using a set of anti-tau specific and phosphorylation dependent mAb's. Intracellular ATP levels were estimated and neurotoxicity was assessed by quantitative measurement of AK in culture medium. Incubation of t40 protein with peroxynitrate generator (Sin-1; 1,25mM) resulted into formation of oligomers (6,1% of total tau). However, the same nitration conditions induced strong dimerization of truncated tau protein (28,7 % of total tau). The data obtained indicate that truncation renders tau more susceptible to nitration. This can be explained by the different tyrosine and cysteine content and different conformation attained after truncation when compared to full length t40 protein. The misfolded truncated tau-expressing neurons treated with Sin-1, displayed dramatically reduced survival. The number of mitochondria in processes of neurons from transgenic animals was significantly decreased (by 33 %) when compared to that present in neurons from control animals. We have shown that tau protein truncation can precede nitrative stress in the pathogenesis of neurodegenerative diseases such as AD and other tauopathies. The nitrative stress strongly increases oligomerization of truncated tau, which probably leads to increased accumulation of aberrant tau proteins in neurons.
Appropriating Value from Ideas: Past and Future Research Trajectories (2014)

Appropriability is a core issue in strategy, innovation management and entrepreneurship. It concerns the extent to which firms or individuals can capture the value generated from their investments (Arrow, 1962; Levin et. al. 1987; Schumpeter, 1950; Teece, 1986). The way in which firms operate, the dynamics of competition and the role of individuals in the product value chain have changed dramatically in the last decades. This calls for the need to reflect more deeply on the issue of appropriability, in order to understand the extent to which some of the core assumptions made, and conclusions reached by existing research in this area are still valid, and to identify new research trajectories. To this end, the symposium will foster an interactive discussion stimulated by the intervention of leading scholars. The key themes discussed will include the strategies used by firms to generate value from their ideas , the type of value that can be generated from ideas, and the isolating mechanisms that firms can use to appropriate value. The symposium will also look at the micro- and macro- implications of the issue by exploring, respectively, the role of individuals and the dynamics of technological change.
Functionalized pyridine in pyclen-based iron(iii) complexes: evaluation of fundamental properties (2020)

The use of tetra-aza pyridinophanes is of increasing interest in the fields of bioinorganic modeling, catalysis, and imaging. However, a full study of how modifications to the pyridyl moiety affect the characteristics of the daughter metal complexes, has not been explored. In this study, six tetra-aza macrocyclic ligands were metalated with Fe(iii) and were characterized for the first time. The pyridyl functional groups studied include: 4-hydroxyl (<b>L1</b>), 4-H (<b>L2</b>), 4-chloro (<b>L3</b>), 4-trifluoromethyl (<b>L4</b>), 4-nitrile (<b>L5</b>), and 4-nitro (<b>L6</b>) modified pyridyl on a pyclen base structure. The resulting iron complexes were characterized by X-ray diffraction analysis, cyclic voltammetry, and metal-binding affinities (log <i>β</i>) were determined. Analysis of these results indicate that such functionalizations introduce a handle by which electrochemical properties and thermodynamic stability of daughter complexes with transition metal ions can be tuned, which in turn, could potentially impact the reactivity of these complexes in future studies.
Correction. Preparation, Structure, and Reactions of Triphenyl Phosphite Complexes of Iron, Ruthenium, and Osmium (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. Preparation, Structure, and Reactions of Triphenyl Phosphite Complexes of Iron, Ruthenium, and OsmiumC Tolman, A English, S Ittel, and J JessonCite this: Inorg. Chem. 1979, 18, 6, 1726Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ic50196a069https://doi.org/10.1021/ic50196a069research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule. (1994)

Sulfatides have been established recently as ligands for L-selectin, and we investigated whether they trigger transmembrane signals through ligation of L-selectin. We found that sulfatides trigger the increase of cytosolic free calcium in neutrophils and that this effect was strictly dependent on sulfation of the galactose ring, as non-sulfated galactocerebrosides were not stimulatory. Chymotrypsin and phorbol 12-myristate 13-acetate treatment of neutrophils caused shedding of L-selectin, but not of class I major histocompatibility complex antigens or beta 2 integrins, and blunted the capability of neutrophils to respond to sulfatides with an increase of cytosolic free calcium. Four different anti-L-selectin antibodies (DREG-200, LAM1/3, LAM1/6, and LAM1/10), but not four control antibodies directed against different surface molecules of neutrophils, also triggered an increase of cytosolic free calcium. The anti-L-selectin antibodies were stimulatory both if used in a soluble form, after cross-linking with anti-mouse F(ab')2 fragments, and immobilized to protein A of Staphylococcus aureus through the Fc fragment. With immobilized antibodies, an increase of cytosolic free calcium was found also by plating neutrophils on antibodies bound to protein A-coated coverslips and monitoring the increase of cytosolic free calcium by fluorescence microscopy. Both sulfatides and anti-L-selectin antibody effects were not inhibited by pertussis toxin, thus indicating that a pertussis toxin-sensitive GTP-binding protein was not involved in signal transduction. Sulfatides also triggered an increase of tumor necrosis factor-alpha and interleukin-8 mRNAs in neutrophils. Also to act as stimuli of cytokine mRNA expression, sulfatides required sulfation of the galactose ring, as non-sulfated galactocerebrosides were not stimulatory, and depended on expression of L-selectin, as shedding of this molecules induced by chymotrypsin blunted their effects. These findings suggest that L-selectin can transduce signals activating selective cell function.
Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB (2020)

Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors are currently being evaluated in clinical trials. This is a clear indication that protein kinases still represent major drug targets for the pharmaceutical industry. In a previous work, we have introduced PKIDB, a publicly available database, gathering PKIs that have already been approved (Phase 4), as well as those currently in clinical trials (Phases 0 to 3). This database is updated frequently, and an analysis of the new data is presented here. In addition, we compared the set of PKIs present in PKIDB with the PKIs in early preclinical studies found in ChEMBL, the largest publicly available chemical database. For each dataset, the distribution of physicochemical descriptors related to drug-likeness is presented. From these results, updated guidelines to prioritize compounds for targeting protein kinases are proposed. The results of a principal component analysis (PCA) show that the PKIDB dataset is fully encompassed within all PKIs found in the public database. This observation is reinforced by a principal moments of inertia (PMI) analysis of all molecules. Interestingly, we notice that PKIs in clinical trials tend to explore new 3D chemical space. While a great majority of PKIs is located on the area of "flatland", we find few compounds exploring the 3D structural space. Finally, a scaffold diversity analysis of the two datasets, based on frequency counts was performed. The results give insight into the chemical space of PKIs, and can guide researchers to reach out new unexplored areas. PKIDB is freely accessible from the following website: http://www.icoa.fr/pkidb.
A low-voltage MOSFET-only ΣΔ modulator for speech band applications using depletion-mode MOS-capacitors in combined series and parallel compensation (2002)

An area-efficient high-linearity MOSFET-only /spl Sigma//spl Delta/ modulator using depletion-mode MOS-capacitors in combined series and parallel compensation technique is presented. The new approach joins the advantages of the series and parallel compensation of depletion-mode MOS-capacitors, achieving an optimum of linearity and area efficiency. The 2/sup nd/-order fully-differential MOSFET-Only /spl Sigma//spl Delta/ modulator was implemented in a standard 0.25 /spl mu/m n-well digital CMOS process without extra layers for capacitors. The circuit operates at 1.8 V supply voltage, consumes 1 mW and achieves a SNR of 77 dB and a SNDR of 71 dB at a signal bandwidth of 8 kHz. The occupied core area is 0.06 mm/sup 2/.
High-Fidelity Preparation, Gates, Memory, and Readout of a Trapped-Ion Quantum Bit (2014)

We implement all single-qubit operations with fidelities significantly above the minimum threshold required for fault-tolerant quantum computing, using a trapped-ion qubit stored in hyperfine "atomic clock" states of ^{43}Ca^{+}. We measure a combined qubit state preparation and single-shot readout fidelity of 99.93%, a memory coherence time of T_{2}^{*}=50 sec, and an average single-qubit gate fidelity of 99.9999%. These results are achieved in a room-temperature microfabricated surface trap, without the use of magnetic field shielding or dynamic decoupling techniques to overcome technical noise.
161. Bridging water in the oxygen-carrying NN′-ethylenebis-(salicylideneiminato)cobalt(II) complex (1965)

P. C. Hewlett and L. F. Larkworthy, J. Chem. Soc., 1965, 882 DOI: 10.1039/JR9650000882
Candida albicans Adherence to Surface‐Modified Denture Resin Surfaces (2008)

The amount of C. albicans adhering to the resin surfaces reduced significantly with modification of surface charge and application of self-bonding polymer. Modification of surface characteristics of polymeric biomaterials is an effective method in reducing adhesion of C. albicans to PMMA surfaces.
An Emulator for Executing IA-32 Applications on ARM-Based Systems (2010)

Virtual Machine (VM) can not only release the processor designers from the burden of ensuring crossplatform compatibility but also provide new opportunities for innovation. Instruction Set Architecture (ISA) emulation is the key aspect of a VM. This paper describes the design and implementation of TransARM-IU, a use-level ISA emulator that supports IA-32 applications on ARMbased systems. This paper also discusses several dedicated solutions to several crucial issues related to the development of TransARM-IU, such as the Executable and Linking Format resolution and hybrid threaded interpretation. In particular, conventional interpretation is implemented in a centralized style which consumes much more execution time. A hybrid threaded interpretation method is proposed to improve the efficiency of the emulator by appending a portion of the simple decoding and dispatching code to the end of each of the instruction interpreter routines. For performance evaluation, we selected 6 benchmarks from MiBench and carried out the experiments on two real ARM-based systems. Experimental results demonstrate the correctness of TransARM-IU in terms of ISA emulation and indicate that TransARM-IU is competitive to other ISA emulators.