gebhart/patrepeval huggingface dataset:
Flat plate millimetre wave antenna based on partially reflective FSS (2001)

A method of simulating the performance of a flat-plate antenna based on partially reflective surfaces is presented. The technique is extended for the design of a highly reflective screen, which produces a high gain planar antenna.
Two-photon absorption studies of polymethine and squaraine dyes with analogous structures (2006)

We compare two-photon absorption spectra of polymethines and squaraines experimentally and quantum-chemically. Squaraines display two-photon cross-sections considerably larger (7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> GM) than polymethines, due to an extra band introduced by the squaraine structure in the conjugated chain.
Effect of garlic on bacterial biofilm formation on orthodontic wire (2011)

Despite its antibacterial function, garlic extract increases biofilm formation by S mutans to orthodontic wire, likely through upregulation of glucosyltransferase expression. Garlic extract may thus play an important role in increased bacterial attachment to orthodontic wires.
A Privacy-Aware PKI System Based on Permissioned Blockchains (2018)

Public key infrastructure (PKI) is the foundation and core of network security construction. Blockchain (BC) has many technical characteristics, such as decentralization, impossibility of being tampered with and forged, which makes it have incomparable advantages in ensuring information credibility, security, traceability and other aspects of traditional technology. In this paper, a method of constructing PKI certificate system based on permissioned BC is proposed. The problems of multi-CA mutual trust, poor certificate configuration efficiency and single point failure in digital certificate system are solved by using the characteristics of BC distribution and non-tampering. At the same time, in order to solve the problem of identity privacy on BC, this paper proposes a privacy-aware PKI system based on permissioned BCs. This system is an anonymous digital certificate publishing scheme., which achieves the separation of user registration and authorization, and has the characteristics of anonymity and conditional traceability, so as to realize to protect user's identity privacy. The system meets the requirements of certificate security and anonymity, reduces the cost of CA construction, operation and maintenance in traditional PKI technology, and improves the efficiency of certificate application and configuration.
A Dual-Band Wireless Power Transmission System for Evaluating mm-Sized Implants (2019)

Distributed neural interfaces made of many mm-sized implantable medical devices (IMDs) are poised to play a key role in future brain-computer interfaces because of less damage to the surrounding tissue. Evaluating them wirelessly at preclinical stage (e.g., in a rodent model), however, is a major challenge due to weak coupling and significant losses, resulting in limited power delivery to the IMD within a nominal experimental arena, like a homecage, without surpassing the specific absorption rate limit. To address this problem, we present a dual-band EnerCage system with two multi-coil inductive links, which first deliver power at 13.56 MHz from the EnerCage (46 × 24 × 20 cm<sup>3</sup>) to a headstage (18 × 18 × 15 mm<sup>3</sup>, 4.8 g) that is carried by the animal via a 4-coil inductive link. Then, a 60 MHz 3-coil inductive link from the headstage powers up the small IMD (2.5 × 2.5 × 1.5 mm<sup>3</sup>, 15 mg), which in this case is a free floating, wirelessly powered, implantable optical stimulator (FF-WIOS). The power transfer efficiency and power delivered to the load (PDL) from EnerCage to the headstage at 7 cm height were 14.9%-22.7% and 122 mW; and from headstage to FF-WIOS at 5 mm depth were 18% and 2.7 mW, respectively. Bidirectional data connectivity between EnerCage-headstage was established via bluetooth low energy. Between headstage and FF-WIOS, on-off keying and load-shift-keying were used for downlink and uplink data, respectively. Moreover, a closed-loop power controller stabilized PDL to both the headstage and the FF-WIOS against misalignments.
The importance of epidemiology in understanding eye disease (1994)

Abstract Most leading causes of visual impairment are age related, so the health care implications of an increasing prevalence of eye disease in the elderly are significant. Epidemiological research provides the foundation to address immediate and long‐term needs associated with visual impairment and eye disease. It contributes to a community's knowledge of the presence, diagnosis, characteristics, and distribution of eye conditions affecting the elderly. Obtaining accurate epidemiological information on the extent of visual impairment and eye disease in the community is essential to determine and estimate the cost of primary and secondary eye health care needs.
Subgingival microbiota in squirrel monkeys with naturally occurring periodontal diseases (1991)

The squirrel monkey (Saimiri sciureus) has been proposed as an in vivo model for the study of subgingival colonization by suspected periodontopathogens, such as black-pigmented porphyromonads and prevotellas (BP/P). However, the indigenous microbiota of the squirrel monkey has not been well described. Therefore, in order to more fully characterize the oral microbiota of these animals, we studied two groups of squirrel monkeys from widely different sources. Group I consisted of 50 breeding colony monkeys ranging in age from 9 months to over 6 years which had been raised in captivity; group II consisted of 16 young sexually mature monkeys recently captured in the wild in Guyana. Group I animals in captivity had developed moderate to severe gingivitis, with a mean gingival index (GI) of 2.6; 52% of the sites bled, 26% had detectable calculus, and 83% had detectable BP/P. A group I subset (six animals), for which predominant cultivable microbiota was described, had a mean GI of 2.4. Colony morphology enumeration revealed that five of the six subset animals were detectably colonized with BP/P (range, 0 to 16.9%) and Actinobacillus actinomycetemcomitans (range, 0 to 3.9%); all subset animals were colonized with Fusobacterium species (range, 0.8 to 3.6%), Actinomyces species (range, 2.3 to 11%), and gram-positive cocci (range, 1.4 to 21.4%). Predominant cultivable microbiota results revealed the presence of many bacterial species commonly found in the human gingival sulcus. At baseline, group II animals were clinically healthy and had a mean GI of 1.4; 67% of the sites bled and 2.1% had calculus, and none of the animals had detectable BP/P. Neisseriae were very common in noninflamed sites. Subsequently, when inflamed sites were compared with noninflamed sites in group II animals after they had been maintained in captivity for 6 months, inflamed sites exhibited a more complex microbiota and increased proportions of gram-negative rods and asaccharolytic bacteria.
Band-edge and random lasing in paintable liquid crystal emulsions (2011)

Lasing mechanisms within paintable dye-doped chiral liquid crystal emulsions are investigated. Evidence shows that by variation in liquid crystal droplet size, by simple control of mechanical mixing speeds, a change in the lasing mechanism from band-edge lasing (large droplets) to diffuse nonresonant random lasing (small droplets) can be facilitated. This approach represents a facile technique for the variation in lasing mechanism, within a self-organizing, flexible, and conformable system, and offers the opportunity of developing controllable linewidth laser sources.
The Impact of Ethereum throughput and fees on the transaction latency during ICOs (2019)

The Ethereum blockchain has gained popularity for its ability to implement Initial Coin Offerings (ICOs), whereby a buyer enters a market order agreement with a seller in order to purchase cryptographic tokens at an agreed price. The popularity of ICOs in 2017 has created an increasingly adversarial environment among potential buyers, who compete for what is often a fixed supply of tokens offered for a limited period of time.&#13;\nWe study the impact of a series of ICOs in order to understand the relationship between transaction fees, throughput and latency in Ethereum. Our analysis considers the effects on both Ethereum’s service providers, known as miners, and users who issue transactions in the network. Our results show that while buyers incentivise miners generously to include their transactions during ICOs, the latency of these transactions is predominantly determined by the levels of supply and demand in the network.
Synthesis and In Vitro Anti-Influenza Virus Evaluation of Novel Sialic Acid (C-5 and C-9)-Pentacyclic Triterpene Derivatives (2017)

The emergence of drug resistant variants of the influenza virus has led to a great need to identify novel and effective antiviral agents. In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2. It was here that we further reported the synthesis and anti-influenza activity of novel sialic acid (C-5 and C-9)-pentacyclic triterpene conjugates. Their structures were confirmed by ESI-HRMS, ¹H-NMR, and <sup>13</sup>C-NMR spectroscopic analyses. Two conjugates (<b>26</b> and <b>42</b>) showed strong cytotoxicity to MDCK cells in the CellTiter-Glo assay at a concentration of 100 μM. However, they showed no significant cytotoxicity to HL-60, Hela, and A549 cell lines in MTT assay under the concentration of 10 μM (except compound <b>42</b> showed weak cytotoxicity to HL-60 cell line (10 μM, ~53%)). Compounds <b>20</b>, <b>28</b>, <b>36</b>, and <b>44</b> displayed weak potency to influenza A/WSN/33 (H1N1) virus (100 μM, ~20-30%), and no significant anti-influenza activity was found for the other conjugates. The data suggested that both the C-5 acetylamide and C-9 hydroxy of sialic acid were important for its binding with hemagglutinin during viral entry into host cells, while C-4 and C-2 hydroxy were not critical for the binding process and could be replaced with hydrophobic moieties. The research presented herein had significant implications for the design of novel antiviral inhibitors based on a sialic acid scaffold.
The Epoxidation of Homoallylic Alcohols and the Formation of Sesquiterpene Diols (1972)

Abstract The epoxidation of homoallylic alcohols was effected with m-chloroperbenzoic acid in ether, and the resulting epoxides were reduced with lithium aluminum hydride to the corresponding diols. Particularly in the cases of calameone and isocalamendiol, the exocyclic double bond at the C3-position was attacked by the peroxy-acid from the side opposite to the axial hydroxyl group at the C5-position.
Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation (2014)

Enzymes involved in collagen biosynthesis, including lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic pulmonary fibrosis. LOX expression is significantly upregulated in bleomycin (BLM)-induced lung fibrosis, and knockdown of LOX expression or inhibition of LOX activity alleviates the lung fibrosis. Unexpectedly, treatment of the mice with LOX inhibitor at the inflammatory stage, but not the fibrogenic stage, efficiently reduces collagen deposition and normalizes lung architecture. Inhibition of LOX impairs inflammatory cell infiltration, TGF-β signaling, and myofibroblast accumulation. Furthermore, ectopic expression of LOX sensitizes the fibrosis-resistant Balb/c mice to BLM-induced inflammation and lung fibrosis. These results suggest that LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury.
C-5 Flexible humidity sensor for sweat monitoring (2015)

We fabricated flexible humidity sensor which responds 10 times faster than commercial CMOS humidity sensor. Our sensor is based on Ionic-Gel-coated Fabric (IG-Fabric). We use EMIMBF_4 as ionic liquid and mixed with PVDF to fabricate ionic gel. The EMIMBF_4 has a characteristic that it absorbs H_2O. IG-Fabric has wide surface area and high gas permeability so that gases can be easily absorbed and detached. This sensor has many applications such as flu-mask-type human breath sensor, wearable sweat monitoring sensor.
De Novo Hybrid Assembled Draft Genome of Commiphora wightii (Arnott) Bhandari Reveals Key Enzymes Involved in Phytosterol Biosynthesis (2023)

Genome sequence and identification of specific genes involved in the targeted secondary metabolite biosynthesis are two essential requirements for the improvement of any medicinal plant. <i>Commiphora wightii</i> (Arnott) Bhandari (family: Burseraceae), a medicinal plant native to Western India, produces a phytosterol guggulsterone, which is useful for treating atherosclerosis, arthritis, high cholesterol, acne, and obesity. For enhanced guggulsterone yield, key genes involved in its biosynthesis pathway need to be predicted, for which the genome sequence of the species is a pre-requisite. Therefore, we assembled the first-ever hybrid draft genome of <i>C. wightii</i> with a genome size of 1.03 Gb and 107,221 contigs using Illumina and PacBio platforms. The N50 and L50 values in this assembled genome were ~74 Kb and 3486 bp, respectively with a guanine-cytosine (GC) content of 35.6% and 98.7%. The Benchmarking Universal Single Copy Ortholog (BUSCO) value indicated good integrity of assembly. Analysis predicted the presence of 31,187 genes and 342.35 Mb repeat elements in the genome. The comparative genome analysis of <i>C. wightii</i> with relevant orthogroups predicted a few key genes associated with phytosterol biosynthesis and secondary metabolism pathways. The assembled draft genome and the predicted genes should help the future variety development program with improved guggulsterone contents in <i>C. wightii</i>.
Substitution scoring matrices for proteins ‐ An overview (2020)

Sequence analysis is the primary and simplest approach to discover structural, functional and evolutionary details of related proteins. All the alignment based approaches of sequence analysis make use of amino acid substitution matrices, and the accuracy of the results largely depends on the type of scoring matrices used to perform alignment tasks. An amino acid substitution matrix is a 20 × 20 matrix in which the individual elements encapsulate the rates at which each of the 20 amino acid residues in proteins are substituted by other amino acid residues over time. In contrast to most globular/ordered proteins whose amino acids composition is considered as standard, there are several classes of proteins (e.g., transmembrane proteins) in which certain types of amino acid (e.g., hydrophobic residues) are enriched. These compositional differences among various classes of proteins are manifested in their underlying residue substitution frequencies. Therefore, each of the compositionally distinct class of proteins or protein segments should be studied using specific scoring matrices that reflect their distinct residue substitution pattern. In this review, we describe the development and application of various substitution scoring matrices peculiar to proteins with standard and biased compositions. Along with most commonly used standard matrices (PAM, BLOSUM, MD and VTML) that act as default parameters in various homologs search and alignment tools, different substitution scoring matrices specific to compositionally distinct class of proteins are discussed in detail.
A Convolutional Neural Network for Lentigo Diagnosis (2020)

Using Reflectance Confocal Microscopy (RCM) for lentigo diagnosis is today considered essential. Indeed, RCM allows fast data acquisition with a high spatial resolution of the skin. In this paper, we use a deep convolutional neural network (CNN) to perform RCM image classification in order to detect lentigo. The proposed method relies on an InceptionV3 architecture combined with data augmentation and transfer learning. The method is validated on RCM data and shows very efficient detection performance with more than 98% of accuracy.
Communication Security in VANETs based on the Physical Unclonable Function (2021)

In this paper we propose an alternative to the security protocols generally developed for VANETs (Vehicular Ad-hoc NETworks), which often rely on asymmetric keys and PKIs (Public Key Infrastructures). Instead, we propose a solution whose architecture is based on Physical Unclonable Functions (PUFs) inside the vehicles. We design a protocol with these PUF functions to securely spread a secret key by means of a Road Side Unit (RSU). This secret key will be used by the vehicles to warn neigboring vehicles of an emergency situation. The key is regularly changed by the RSU but its value evolves slowly over time in a random way. Thus a message using an old (but not too old) key can be accepted as valid. We define the whole protocol where a vehicle first identifies itself to the Road Side Unit for authentication. Then the RSU sends back a key which will be used to send alerts if an emergency situation occurs on the road. The RSU manages the evolution of this key by just randomly changing one bit at each change. Thus an alert can be accepted if the key used to issue an alert is "close" to the last key issued by the RSU. We investigate the advantages of this new scheme and evaluate the implications in terms of exchanges between the vehicles (and their PUFs) and the network connecting the RSUs.
TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 (2018)

Mechanically induced signaling pathways are important drivers of tumor progression. However, if and how mechanical signals affect metastasis or therapy response remains poorly understood. We previously found that the channel-kinase TRPM7, a regulator of cellular tension implicated in mechano-sensory processes, is required for breast cancer metastasis in vitro and in vivo. Here, we show that TRPM7 contributes to maintaining a mesenchymal phenotype in breast cancer cells by tensional regulation of the EMT transcription factor SOX4. The functional consequences of SOX4 knockdown closely mirror those produced by TRPM7 knockdown. By traction force measurements, we demonstrate that TRPM7 reduces cytoskeletal tension through inhibition of myosin II activity. Moreover, we show that SOX4 expression and downstream mesenchymal markers are inversely regulated by cytoskeletal tension and matrix rigidity. Overall, our results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4.
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks (2022)

ABSTRACT Toxins TcdA and TcdB are the main virulence factors of Clostridioides difficile , a leading cause of hospital-acquired diarrhea. We investigated the therapeutic potential of inhibiting the biosynthesis of TcdA and TcdB. Accordingly, screening of structurally diverse phytochemicals with medicinal properties identified 18β-glycyrrhetinic acid (enoxolone) as an inhibitor of TcdA and TcdB biosynthesis. Enoxolone also inhibited sporulation. In a CDI colitis model, enoxolone when combined with vancomycin protected mice from becoming moribund and the combination was more effective than vancomycin alone, a standard of care antibiotic for CDI. While enoxolone alone reduced the in vivo load of toxins, the monotherapy did not protect mice from CDI. Affinity based proteomics identified ATP synthase subunit alpha (AtpA) and adenine deaminase (Ade) as possible molecular targets for enoxolone. Silencing of mRNA for Ade and AtpA also reduced toxin biosynthesis, while molecular interaction analysis showed that enoxolone directly bound to Ade. Ade converts adenine to hypoxanthine as an early step in the purine salvage pathway. Metabolomics revealed enoxolone caused cells to accumulate adenosine and deplete hypoxanthine and ATP. Accordingly, supplementation with hypoxanthine partly restored toxin production. Enoxolone also impacted phosphate metabolism by reducing the amounts of cellular phosphate. Thus, supplementation with triethyl phosphate as a source of phosphate also partly restored toxin production. When hypoxanthine and triethyl phosphate were combined, toxin production was fully restored in the presence of enoxolone. Taken together, studies with enoxolone revealed metabolic pathways that affect C. difficile toxin production and could represent potential anti-virulence drug targets. IMPORTANCE Clostridioides difficile , a leading cause of hospital-acquired diarrhea, produces two co-regulated toxins (TcdA and TcdB) that are the focus of most anti-virulence discovery efforts for C. difficile infection (CDI). Exploration of an alternate anti-virulence strategy led to the discovery that the licorice metabolite enoxolone inhibits C. difficile virulence by blocking the cellular biosynthesis of TcdA and TcdB. Blockage of toxin production by enoxolone was associated with multiple effects on cells, including inhibiting adenine deaminase and ATP synthase leading to disruption of purine biosynthesis and phosphate metabolism. In mice infected with C. difficile , the efficacy of enoxolone in combination with vancomycin was superior to vancomycin alone. These findings contribute to establishing toxin biosynthesis inhibition as a newer therapeutic concept for CDI.
Sequential Involvement of Oculomotor Nerve and Optic Nerve Sheath in Relapsing Polychondritis (2021)

Ikeda, Toshihide MD; Yoshida, Takeshi MD; Yamamoto, Hirotaka MD; Hashida, Masatsugu MD, PhD; Urabe, Kimiaki MD; Sotozono, Chie MD, PhD; Fukuda, Ken MD, PhDEditor(s): Avery, Robert DO; Golnik, Karl C. MD; Froment, Caroline MD, PhD; Wang, An-Gour MD Author Information
Optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and related compounds (1976)

The optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and 2-(3-methoxyphenoxymethyl)tetrahydro-1,4-oxazine have been prepared and absolute configurations have been assigned. In their action on the central nervous system the S isomers are at least ten times more potent than the R isomers. The intermediate 4-benzyl-2-(p-toluensulfonyloxymethyl)tetrahydro-1,4-oxazine has been resolved. Its isomers provide a convenient starting point for the preparation of optical isomers of viloxazine analogues of known configuration.
Novel Lavendamycin Analogues as Potent HIV-Reverse Transcriptase Inhibitors:  Synthesis and Evaluation of Anti-Reverse Transcriptase Activity of Amide and Ester Analogues of Lavendamycin (2003)

Novel lavendamycins including two water soluble derivatives were synthesized via short and efficient methods. Pictet-Spengler condensation of 7-N-acylamino-2-formylquinoline-5,8-diones with tryptophans produced lavendamycin esters or amides 11-17. Lavendamycins 18-21 were obtained, respectively, by further transformations of 13-15 and 17. Several lavendamycins were found to be potent HIV reverse transcriptase inhibitors with very low toxicity in vitro and in vivo. Several compounds also acted either additively or synergistically to inhibit enzyme activity together with AZT-triphosphate.