gebhart/patrepeval huggingface dataset:
In Situ Dielectric Characterization of Poly(ethylene oxide) Melts Containing Lithium Perchlorate under Steady Shear Flow (2003)

For poly(ethylene oxide) (PEO) melts containing lithium perchlorate (LiClO4), angular frequency ω dependence of the dynamic dielectric properties under steady shear flow was measured using a rheodielectric instrument. The instrument also enabled measurements of the dielectric properties in the quiescent state as well as the linear and nonlinear rheological properties. A significant increase in the zero-shear viscosity η0 was observed upon addition of LiClO4 to PEO, and this increase was attributed to Li+-mediated intermolecular bridging of the PEO chains formed in the quiescent state. Significant shear thinning of the steady-state viscosity η(γ̇) was observed with increasing shear rate γ̇, suggesting the flow-induced breakup of these bridges. The presence of liberated ions was detected directly by dielectric experiments under steady shear flow. The dielectric dispersion (due to the electrode polarization of the ions) shifted to higher ω with increasing γ̇, indicating an increase in the ionic conductivity σ. The dispersion curves for different γ̇ values collapsed onto a single master curve when plotted against a reduced frequency, {λ(γ̇)}-1ω, where λ(γ̇) was a γ̇-dependent shift factor representing the increase of σ. This result strongly suggested that the increase of σ under shear flow was due to an increase in the ionic mobility μ by the factor of λ(γ̇) and not due to a change in the number density of ions. Furthermore, excellent agreement was found between the η(γ̇)/η0 ratio and {λ(γ̇)}-1. This agreement reflected a strong motional cooperativivity between the PEO chain segment and ion (Li+).
Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix. (1990)

The expression of tissue-specific functions by hepatocytes in primary culture is enhanced in the presence of an extracellular matrix. A basement membrane-like substratum, derived from the Engelbreth-Holm-Swarm mouse sarcoma (EHS) and termed EHS gel, supports synthesis and secretion of albumin for at least three weeks, in contrast to a conventional substratum (plastic or collagen-coated plastic), on which cells rapidly lose this function. The presence of an EHS matrix (as a substratum or added to the medium as a dilute gel) supports transcriptional activity at 30 to 35% and specific mRNA at 70 to 80% of initial values after five days of culture, at a time when transcription in cells plated in conventional culture is undetectable. For examining the cis elements required for transcriptional regulation by EHS matrix, we are utilizing recombinant adenoviruses to introduce DNA into hepatocytes, as an alternative to transfection of DNA fragments. Initial studies are presented, in which hepatocytes are cultured on either collagen-coated plastic or on EHS gel. At various times after plating, the cultures are infected with an adenovirus containing the proximal 5' regulatory region (to -441 base-pair) of the albumin gene. The results indicate no effect of EHS gel on this proximal promoter region, implying that matrix-responsive element(s) lie further upstream, possibly within the previously described enhancer at about -10,000 base-pairs.
The Endocannabinoid System in Amyotrophic Lateral Sclerosis (2008)

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition characterised by the selective loss of motor neurons from the spinal cord, brainstem and motor cortex. Although the pathogenic mechanisms that underlie ALS are not yet fully understood, there is significant evidence that several neurotoxic mechanisms including excitotoxicity, inflammation and oxidative stress, all contribute to disease pathogenesis. Furthermore, recent results have established that although primarily a motor neuron specific disorder, ALS is not cell-autonomous and non-neuronal cells including astroglia and microglia play a critical role in mechanism of disease. Currently the only licensed therapy available for the treatment of ALS is the anti-glutamatergic agent Riluzole, which has limited therapeutic effects. However, there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors, respectively. Activation of CB(1) receptors may therefore inhibit glutamate release from presynaptic nerve terminals and reduce the postsynaptic calcium influx in response to glutamate receptor stimulation. Meanwhile, CB(2) receptors may influence inflammation, whereby receptor activation reduces microglial activation, resulting in a decrease in microglial secretion of neurotoxic mediators. Finally, cannabinoid agents may also exert anti-oxidant actions by a receptor-independent mechanism. Therefore the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations may increase their therapeutic potential in the treatment of ALS. Recent studies investigating this potential in models of ALS, in particular those that focus on strategies that activate CB(2) receptors, are discussed in this review.
An Allergen Portrait Gallery: Representative Structures and an Overview of IgE Binding Surfaces (2010)

Recent progress in the biochemical classification and structural determination of allergens and allergen-antibody complexes has enhanced our understanding of the molecular determinants of allergenicity. Databases of allergens and their epitopes have facilitated the clustering of allergens according to their sequences and, more recently, their structures. Groups of similar sequences are identified for allergenic proteins from diverse sources, and all allergens are classified into a limited number of protein structural families. A gallery of experimental structures selected from the protein classes with the largest number of allergens demonstrate the structural diversity of the allergen universe. Further comparison of these structures and identification of areas that are different from innocuous proteins within the same protein family can be used to identify features specific to known allergens. Experimental and computational results related to the determination of IgE binding surfaces and methods to define allergen-specific motifs are highlighted.
Unlocking Design Reuse with Hardware Compiler Frameworks (2019)

Emerging applications from the edge to the cloud are constantly increasing demand for energy efficient and performant computation. While specialized hardware can meet these power and performance goals, the high non-reoccurring engineering (NRE) costs of designing, testing, and verifying custom hardware severely hinders its supply. Hardware construction languages such as Chisel enable hardware designers to write parameterized hardware libraries which increase design reuse by turning NRE effort into reusable solutions for future specialized chips. This thesis introduces FIRRTL, Chisel’s hardware compiler framework, which enables automatic and custom RTL-transformations including logic optimization and design instrumentation. In addition, this thesis proposes an aspect-oriented-inspired paradigm, Colla-Gen, as a mechanism to improve design collateral reuse (e.g. physical design floorplanning or verification instrumentation), which forms another large portion of chip NRE costs.
Distributed processing of multimedia extended documents (1999)

In this paper we present a new approach toward processing of multimedia documents. We use intelligence derived from media and processing dependencies and distribute the processing according to logical progression of the media processing tasks. To achieve this we devised a management strategy which takes as an input a user defined problem with pre-coded processing tools and maps to distributable tasks which have an associated resource requirements. At the last step of the processing, the available processing nodes, which vary in available resources, are matched to the processes. An example demonstrating the capabilities of this system is presented.
A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyseCandida albicanscells in biofilms (2011)

The ability of Candida albicans to form drug-resistant biofilms is an important factor in its contribution to human disease. Assays to identify and characterize molecules with activity against fungal biofilms are crucial for the development of drugs with improved anti-biofilm activity. Here we report the application of an adenylate kinase (AK)-based cytotoxicity assay of fungal cell lysis to the characterization of agents active against C. albicans biofilms. We have developed three protocols for the AK assay. The first measures AK activity in the supernatants of biofilms treated with antifungal drugs and can be performed in parallel with a standard 2,3-bis-(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-caboxanilide-based biofilm susceptibility assay; a second, more sensitive protocol measures the AK activity present within the biofilm matrix; and a third procedure allows the direct visualization of lytic activity toward biofilms formed on catheter material. Amphotericin B and caspofungin, the two most effective anti-biofilm drugs currently used to treat fungal infections, both directly lyse planktonic C. albicans cells in vitro, leading to the release of AK into the culture medium. These studies serve to validate the AK-based lysis assay as a useful addition to the methods for the characterization of antifungal agents active toward biofilms and provide insights into the mode of action of amphotericin B and caspofungin against C. albicans biofilms.
Development of fluoride materials for neutron detection (2022)

Abstract We have studied various lithium containing fluoride materials as neutron scintillators for the last 15 years. Fluoride scintillator samples were prepared by melt growth techniques and their scintillation properties were investigated under thermal neutron irradiation. Developed fluoride scintillators show non-hygroscopicities and full-absorption peaks in the pulse height spectra under thermal neutron irradiation. The highest light yield among the samples was approximately 40000 photons/neutron. Several fluoride materials can be used as a non-hygroscopic neutron scintillators.
Higher Intake of Sulfur Amino Acids Is Associated with Greater Mortality Among US Adults: NHANESIII Cohort Study (P18-061-19) (2019)

Preclinical evidence has suggested that low consumptions of sulfur amino acids (SAA) methionine (Met) and cysteine (Cys) are associated with a variety of health benefits including delayed aging and lower incidence of aging-related diseases including diabetes. Further, in the United States, the average person consumes SAA at levels far in excess of the Recommended Dietary Allowance (RDA) and a variety of negative effects of excess SAA intake have been reported. However, there is little data regarding the relationship between SAA intake and health status in humans. We thus prospectively analyzed the associations between SAA intake and all-cause and disease-specific mortality rates in a large cohort of US adults participating in the Third National Examination and Nutritional Health Survey (NHANES III) Study. Dietary intake of SAA was assessed via a 24-h recall questionnaire. Mortality cases were assessed via search in the National Death Index. Hazard ratios (HR) were calculated from Cox proportional hazards models to evaluate associations between intakes of SAAs intake (in quintiles) and risk of mortality. Models were adjusted for age, sex, body mass index (BMI), smoking, alcohol intake, dietary factors, and disease history. A total of 3594 mortality events out of 12,395 eligible participants occurred during 23 years of follow-up. After full adjustment, absolute intake of higher Met, Cys, and total SAA were associated with increases in all-cause mortality (HR = 1.13 (1.00–1.13), 1.15 (1.01–1.30), 1.13 (1.00–1.27), respectively), and in diabetes mortality (HR = 3.00 (1.53–5.70), 3.26(1.65–6.46), 3.81(1.87–7.77), respectively). No associations were found with other causes of mortality. When SAA intake was expressed as protein density, only Cys and total SAA intake were positively associated with increased diabetes mortality (P < 0.02). Overall, these data support our hypothesis that higher consumption of SAA is associated with increased mortality. Given the high intake of SAA among the US population, our findings may have important public health implications. This study was not externally funded.
Painting with bacteria: Smart templated self assembly using motile bacteria (2017)

Dataset supporting the manuscript entitled 'Painting with bacteria: Smart templated self assembly using motile bacteria': External control of the swimming speed of ‘active particles’ can be used to self assemble designer structures in situ on the µm to mm scale. We demonstrate such reconﬁgurable templated active self assembly in a ﬂuid environment using light powered strains of Escherichia coli. The physics and biology controlling the sharpness and formation speed of patterns is investigated using a bespoke fast-responding strain.
The Design and Implementation of a General Reduced TCP/IP Protocol Stack for Embedded Web Server (2006)

The embedded Web server technology is the combination of embedded device and Internet technology, which provides a flexible remote device monitoring and management function based on Internet browser and it has become an advanced development trend of embedded technology. In this paper, a design and implementation scheme of a general reduced Web server protocol stack which aims at the limited resources characteristic that the embedded system has was proposed based on AT90S8515 single chip that uses RISC technology and RTL-8019 network interface controller hardware platform. The overall design issue was thoroughly discussed and the implementation methods of core protocols in protocol stack such as 802.3, ARP, IP, TCP and HTTP were analyzed in detail.
Supplementary Tables S1 and S2 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients (2023)

&lt;p&gt;Table S1. Percentage and absolute number of alloreactive NK cells in responders (A) and non-responders (B) Table S2. Description of cell processing results in responders (A) and non-responders (B)&lt;/p&gt;
HRTF filter design based on auditory criteria (1996)

this paper, new methods for HRTF filter design using auditory criteria are presented. New classes of digital filters, namely warped FIR (WFIR) and IIR (WIIR) structures and their application to binaural processing are studied. The bilinear transform is used to warp the frequency scale to a nonuniform resolution, e.g., to match the critical bands of the human ear. Examples of warped filter design are presented. The implementation of WFIR and WIIR filters in real-time binaural applications is discussed. Results of the comparison between warped and traditional HRTF filter design methods are given. The paper is organized as follows. In Section 2, an overview of the properties and modeling strategies of HRTFs is given. Frequency warping and the application of warped filter structures to HRTF modeling are presented in Section 3. Finally, conclusions are drawn and directions for future research are given in Section 4.
The Perfectly Conducting Grating from the Point of View of Inverse Diffraction (1979)

We present here the first study of gratings from the point of view of inverse diffraction. The problem is, given data on the far scattered field, to find the profile of the grating. A very general method is proposed here: using the concept of the Fréchet differential, we show that it is possible to find a numerical algorithm in order to reconstitute the profile. One encounters the fundamental instability, linked with all the problems of inverse scattering. In order to overcome this difficulty, we have used the Tikhonov method of regularization. Finally, we show several examples of reconstitution for various gratings. In the near future, we hope to apply our method to the case of finite conductivity gratings.
MP66-14 PROSTATE CANCER BONE METASTASIS-SPECIFIC MITOCHONDRIAL DNA MUTATION INCREASES REACTIVE OXYGEN. (2016)

was assessed by Western blot analysis and quantitative reverse transcription-PCR. To assess LASP1 function, we generated stable LASP1 knockdown and overexpression cell lines. For our cell growth assay, we used anchorage-independent growth conditions in 24 well plates coated with poly-Hema and monitored growth by WST-8 assay. To determine invasiveness, we monitored movement of cell through Matrigel coated invasion chambers. To measure tumorigenicity, in vivo tumor formation was assessed in mice xenografted with LNCaP cells overexpressing LASP1 RESULTS: Compared to low LASP1 expression, high LASP1 expression in prostate cancer is prone to early metastasis after radical prostatectomy (P0.0423). High LASP1 correlated with prostate cancer-specific mortality after radical prostatectomy (P<0.001). Knockdown of LASP1 in VehA (CRPC cells) and PC3 cells inhibited cell growth. Furthermore, knockdown of LASP1 in PC3 cells significantly decreased cell invasion and was accompanied by a decrease in snail and slug expression. Overexpression of LASP1 in LNCaP cells promoted cell growth. Nanog, a stemness-related marker, was increased by knockdown of LASP1 and decreased by overexpression of LASP1.
Electronic, Fiber-Optic Technology: Future Options for Permanent Reservoir Monitoring (1994)

Abstract According to current trends, it is likely that in the near future the oil &amp; gas industries will have to choose between electronic and fiber optic systems for the continuous measurement of down-hole pressure and temperature (permanent reservoir monitoring). The aim of this paper is to give a view beyond the facade of the up-to-date electronic and fiber optic technology in order to provide a critical evaluation of the degree of maturity of both technologies from an operator’s point of view and to define some realistic prospects of application in the short/medium term period.
Fiber-based high-resolution OCT system with halogen light source (2004)

Fiber-based high resolution OCT system was achieved using white-light source with a halogen lamp, which has advantages of wide spectrum, compact size and low cost. The axial resolution measured without using objective lens in the sample arm was about 2.5 mm. The thickness of a thin film (about 7 mm thick) was measured to evaluate the high resolution performance. The measured interferogram showed two well-distinguished peaks corresponding to two interfaces of the thin film. The implemented OCT system was composed of fiber-optic Michelson interferometer instead of that of conventional bulk optics. To adapt a white-light source to the fiber based OCT system and providing high resolution, a wideband single mode fiber with a large mode field diameter for high coupling efficiency, a wideband fiber coupler with flat coupling response, a cascaded detector scheme for broadband detection and dispersion control are required. Dispersion mismatch due to introducing an objective lens in the sample arm can be controlled effectively by employing a proper optical component in the reference arm. After dispersion control, resolution of about 3.5 mm was enhanced to about 2.5 mm, which is similar to the objective lens-free resolution, and wide sidelobes was also well suppressed.
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer’s Disease (2019)

We conclude that the combination of two pharmacophores with a synergistic mechanism of action into a single molecule offers great potential for the treatment of CNS disorders associated with cognitive decline and/or excitotoxicity mediated by NMDARs.
A validation project of Copenhagen Psychosocial Questionnaire in Sweden (2013)

Introduction&#13;\nHealth care in Sweden has gone through major re-organization during the last two decades, and the pace of change continues to be high. Reliable instruments to monitor the situation, even at the local level, are needed. Copenhagen Psychosocial Questionnaire (COPSOQ) is a suitable staff questionnaire for mapping the psychosocial working environment as well as for evaluating changes following interventions. The intention is to present the ongoing validation project of the Swedish version of COPSOQ for use in health care organizations at the symposium.&#13;\nThe target group of this research project is first line health care workers with a short education and the aim is to&#13;\n&#13;\n* validate the existing Swedish translation of COPSOQ and further develop scales specifically directed towards personally enriching aspects in human service work;&#13;\n* map the psychosocial work environment, stress, and wellbeing of first-line health care workers aiming to establish reference values as well as to analyze the interplay between individual and group factors in relation to outcomes such as sickness absence and staff turnover.&#13;\n&#13;\nMaterial and methods&#13;\nThe project includes back-translation, cognitive debriefing interviews, a cross-sectional study at public dental practices and hospital wards, as well as register data at group level.&#13;\n&#13;\nResults&#13;\nPreliminary results from the back-translation procedure show challenges in relations to conceptual equivalence between some items in the existing Swedish version of COPSOQ and the official English version and a need for adjustments to improve clarity and the use of ordinary contemporary language. Interviews are ongoing and preliminary results will be presented at the symposium.&#13;\n&#13;\nConclusions&#13;\nImproved knowledge about the psychosocial working environment and health among first line health care workers would increase the opportunities for promoting future working conditions which positively influence motivation, health and willingness to stay on the labor market and in the caring professions. This would support a sustainable health care system likely contributing to organizational efficiency, quality in patient-work, and a good work life for employees.&#13;\nFunding&#13;\nThe project is funded by the Swedish Research Council for Health, Working Life and Welfare (FORTE).
Osteomyelitis and arthrosynovitis associated with Leishmania donovani infection in a dog (1997)

A 10-month-old male maremma shepherd dog was presented with chronic diarrhoea, moderate polyuria/polydipsia, lethargy, dysorexia and stiffness. Pain was elicited in the distal parts of all four limbs. Radiographs of the limbs showed increased endomedullary radiopacity and lysis, with thick periosteal proliferations at the metadiaphyseal areas of each radius-ulna and tibia and of the distal metacarpus on one side. Polyclonal hypergammaglobulinaemia was documented and a similar electrophoretic protein pattern was also found in the synovial fluid. Leishmania amastigotes were found in the macrophages in a bone marrow aspirate performed at the level of a distal radius and in a synovial fluid sample obtained from a carpal joint. An indirect immunofluorescence test confirmed the infection. Treatment with N-methyl-glucamine antimoniate was successful and the osteoarticular changes progressively disappeared.
Dynamic object identification and verification using video (1999)

We introduce the concepts of dynamic object identification and verification using video. A generalized Hausdorff metric, which is more robust to noise and allows a confidence interpretation, is suggested for the identification and verification problem. Parameters from sensor motion compensation procedure are incorporated into the search step such that the Hausdorff metric based matching can be achieved efficiently under more complex transformation groups. An algorithm is proposed for identification/verification based on edge map matching using the generalized Hausdorff metric. Experiments on infrared video sequences are provided.