gebhart/patrepeval huggingface dataset:
Operational Experience With the GEM Detector Assembly Lines for the CMS Forward Muon Upgrade (2018)

The CMS Collaboration has been developing large-area triple-gas electron multiplier (GEM) detectors to be installed in the muon Endcap regions of the CMS experiment in 2019 to maintain forward muon trigger and tracking performance at the High-Luminosity upgrade of the Large Hadron Collider (LHC); 10 preproduction detectors were built at CERN to commission the first assembly line and the quality controls (QCs). These were installed in the CMS detector in early 2017 and participated in the 2017 LHC run. The collaboration has prepared several additional assembly and QC lines for distributed mass production of 160 GEM detectors at various sites worldwide. In 2017, these additional production sites have optimized construction techniques and QC procedures and validated them against common specifications by constructing additional preproduction detectors. Using the specific experience from one production site as an example, we discuss how the QCs make use of independent hardware and trained personnel to ensure fast and reliable production. Preliminary results on the construction status of CMS GEM detectors are presented with details of the assembly sites involvement.
Impact of antiretroviral therapy interruption on plasma biomarkers of cardiovascular risk and lipids: 144‐week final data from the STOPAR study (2012)

A significant increase in cardiovascular risk biomarkers persisting over the prolonged study period was seen in the TI arm. This factor may contribute to the increased cardiovascular risk observed in previous studies.
Incremental Clustering for Mining in a Data Warehousing Environment (1998)

Data warehouses provide a great deal of opportunities for performing data mining tasks such as classification and clustering. Typically, updates are collected and applied to the data warehouse periodically in a batch mode, e.g., during the night. Then, all patterns derived from the warehouse by some data mining algorithm have to be updated as well. Due to the very large size of the databases, it is highly desirable to perform these updates incrementally. In this paper, we present the first incremental clustering algorithm. Our algorithm is based on the clustering algorithm DBSCANwhich is applicable to any database containing data from a metric space, e.g., to a spatial database or to a WWW-log database. Due to the density-based nature of DBSCAN, the insertion or deletion of an object affects the current clustering only in the neighborhood of this object. Thus, efficient algorithms can be given for incremental insertions and deletions to an existing clustering. Based on the formal defin...
Novel wire-grid nantenna array for optical communication systems (2013)

A novel wire-grid array of nanorods is introduced for the first time in this paper. The array consists of five gold radiating rods and four gold perpendicular connecting rods. Via optimizing the lengths of the radiators and connectors, high value of directivity has been obtained. The new array is designed for operation at a wavelength of 1.55 μm, which is commonly used by optical communication system. The overall physical and electrical sizes of the array are (0.68 μm -by- 1.05 μm) and (3λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> /2 -by- λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ), respectively, with a maximum directivity of 9.25 dBi. The new array is analyzed using a commercial full-wave finite-difference time-domain package. It provides symmetric radiation pattern with reasonable side-lobe-level and extremely low cross-polarization level.
Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery (2015)

German Clinical Trials Register Identifier: DRKS00005333.
Theaman6Gene Encoding a Yeast Mannan Backbone Degrading 1,6-α-D-Mannanase inBacillus circulans: Cloning, Sequence Analysis, and Expression (2000)

A gene (aman6) encoding endo-1,6-alpha-D-mannanase, a yeast mannan backbone degrading enzyme from Bacillus circulans was cloned. The putative aman6 was 1,767 base pairs long and encoded a mature 1,6-alpha-D-mannanase protein of 589 amino acids and a signal peptide of 36 amino acids. The purified mature 1,6-alpha-D-mannanase from the Escherichia coli transformant showed 61-kDa protein, and N-terminal amino acid sequence and other general properties of the recombinant enzyme were identical to those of 1,6-alpha-D-mannanase from Bacillus circulans TN-31.
Molecular Interaction Between Butorphanol and K-opioid Receptor (2021)

( Anesth Analg . 2020;131:935–942) An estimated 4% of adults in the United States misuse prescription opioids, caused in part by inappropriate prescribing. There is a lack of understanding of the pharmacological profiles of opioids and their medical indications. Butorphanol is a schedule intravenous opioid, less likely to be abused than morphine, but a more potent analgesic. Morphine is a full μ-opioid receptor agonist, while butorphanol is a partial μ-opioid receptor agonist and a K-opioid receptor (KOR) agonist. The butorphanol and KOR interactions between may be unique and of pharmacological and clinical importance. This study used computational and in vitro experiments to explore the interactions between butorphanol and KOR.
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis (2012)

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.
A segmentation and point-matching enhanced efficient deformable image registration method for dose accumulation between HDR CT images (2015)

Deformable image registration (DIR) of fractional high-dose-rate (HDR) CT images is challenging due to the presence of applicators in the brachytherapy image. Point-to-point correspondence fails because of the undesired deformation vector fields (DVF) propagated from the applicator region (AR) to the surrounding tissues, which can potentially introduce significant DIR errors in dose mapping. This paper proposes a novel segmentation and point-matching enhanced efficient DIR (named SPEED) scheme to facilitate dose accumulation among HDR treatment fractions. In SPEED, a semi-automatic seed point generation approach is developed to obtain the incremented fore/background point sets to feed the random walks algorithm, which is used to segment and remove the AR, leaving empty AR cavities in the HDR CT images. A feature-based 'thin-plate-spline robust point matching' algorithm is then employed for AR cavity surface points matching. With the resulting mapping, a DVF defining on each voxel is estimated by B-spline approximation, which serves as the initial DVF for the subsequent Demons-based DIR between the AR-free HDR CT images. The calculated DVF via Demons combined with the initial one serve as the final DVF to map doses between HDR fractions. The segmentation and registration accuracy are quantitatively assessed by nine clinical HDR cases from three gynecological cancer patients. The quantitative analysis and visual inspection of the DIR results indicate that SPEED can suppress the impact of applicator on DIR, and accurately register HDR CT images as well as deform and add interfractional HDR doses.
Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum (2015)

Cells must divide strictly along a plane to form an epithelial layer parallel to the basal lamina. The axis of cell division is primarily governed by the orientation of the mitotic spindle and spindle misorientation pathways have been implicated in cancer initiation. While β1-Integrin and the Dynein/Dynactin complex are known to be involved, the pathways linking these complexes in positioning mitotic spindles relative to the basal cortex and extracellular matrix remain to be elucidated. Here, we show that Integrin-Linked Kinase (ILK) and α-Parvin regulate mitotic spindle orientation by linking Dynactin-1 and Dynactin-2 subunits of the Dynein/Dynactin complex to Integrin receptors at the basal cortex of mitotic cells. ILK and α-Parvin are required for spindle orientation. ILK interacts with Dynactin-1 and Dynactin-2 and ILK siRNA attenuates Dynactin-2 localization to the basal cortex. Furthermore we show that Dynactin-2 can no longer colocalize or interact with Integrins when ILK is absent, suggesting mechanistically that ILK is acting as a linking protein. Finally we demonstrate that spindle orientation and cell proliferation are disrupted in intestinal epithelial cells in vivo using tissue-specific ILK knockout mice. These data demonstrate that ILK is a linker between Integrin receptors and the Dynactin complex to regulate mitotic spindle orientation.
The Performance of an Isolated Word Recognizer Using Noisy Speech. (1983)

Abstract : This report investigates the effects of noise on a speaker dependent, isolated work recognition system. Correct word recognition in a noise-free environment exists in a variety of present-day applications. However, when the acoustic environment includes noise, the problem of correct word recognition becomes more difficult. The noise interferes with the accurate location of the work boundaries and also distorts the spectral representation of the speech waveform. A series of experiments were performed to determine (1) the effects of using an energy-based endpoint detector and a conventional isolated word recognition system when the input speech is noisy and (2) the effects of placing a noise suppression prefilter in tandem with the word recognizer in an attempt to remove the noise prior to recognition. It was found that the system consisting of the prefilter working in tandem with the word recognizer increased word recognition accuracy.
Forced Electrocodeposition of Silica Particles into Nickel Matrix by Horizontal Impinging Jet Cell (2017)

The improvement of silica particle codeposition into a nickel electrodeposited composite coating (ECC) by a double face horizontal impinging jet cell (IJC) has been studied. The microstructure of coatings was examined by means of scanning electron microscopy performed in backscattered electron mode. The embedded particles distribution was shown to be the densest and the most uniform in laminar low flow mode and when the nozzle is at a distance of 5 mm close from the cathode. Excrescences observed on the composite surface are due to the wave-like flow of the jet on the cathode surface. The silica content of the nickel composite coatings was assessed by energy dispersive X-ray spectroscopy. The amount of particles embedded in the coating decreases with an increasing Reynolds number and as the nozzle-to-sample distance d becomes larger. A maximum rate of 4.43 wt% of silica has been successfully loaded at a distance d equal to 5 mm in the Ni-SiO2 composite coating.
Effect of Three Different Modes of Alcohol Administration on the Activity of the Rat Hypothalamic-Pituitary-Adrenal Axis (1997)

The present study compared the effect of different modes of alcohol administration on the activity of the hypothalamic-pituitary-adrenal (HPA) axis. In a first series of studies, we investigated the influence of the intraperitoneal (ip) and intragastric (ig) effect of acutely administered alcohol. Over a 3–hr period, alcohol induced dose-related increases in adrenocorticotropic hormone (ACTH) and alcohol levels in the circulation. There was a good correlation between blood ACTH and alcohol levels (ip treatment, R= 0.84; ig treatment, R= 0.79). Measurement of steady-state mRNA of the immediate early gene NGFI-B, taken as an index of neuronal activation in the paraventricu-lar nucleus (PVN) of the hypothalamus of rats administered 3 g of alcohollkg, indicated significant (p < 0.01) increases between 60 and 180 min after both ip and ig alcohol injection, with peak stimulation at 1 and 2 hr, respectively. Although NGFI-6 mRNA levels had returned to control level in the parvicellular portion of the PVN of animals administered the drug ip 4 hr earlier, they were still significantly (p < 0.01) elevated 4 hr after ig treatment. A second series of studies used rats fed an alcohol diet containing 6.4% alcohol (w/v), or pair-fed. The rats were tested during the 4th or 6th night of treatment. Despite blood alcohol levels ranging between 0.060 and 0.140% w/v, there was no significant rise in plasma ACTHlcorticosterone levels in animals fed the drug, and no detectable NGFI-B mRNA in their PVN. Collectively, these results indicate that both the ip and the ig acute injection of alcohol induced dose-related increases in plasma ACTH levels. PVN neuronal activation was also observed. In contrast, the alcohol diet had no effect on HPA hormone levels or PVN expression Of NGFI-B.
Image quality and safety after iodixanol in intravenous urography; a comparison with iohexol (1996)

A double-blind, randomized phase III study compared intravenous urography in 100 adult patients receiving iodixanol 320 mgI ml-1 (Visipaque) with 99 patients receiving iohexol 350 mgI ml-1 (Omnipaque). The aim of the study was to investigate differences in image quality between a non-ionic dimeric contrast medium (CM) and a non-ionic monomer at 40 ml per patient and 60-100 ml per patient volume levels. There were no statistically significant differences between iodixanol and iohexol with respect to overall diagnostic information, which was found to be optimal in 86% and 79%, respectively. Immediately after the injection, the renal border was better delineated with iohexol than with iodixanol (p = 0.0001). Marked papillary blush occurred more often in the iodixanol group (16%) than in the iohexol group (0%), as did visualization of the collecting ducts (24% vs 5%) (p = 0.001). The incidence of adverse events was similar and low for both contrast media. In patients who received the higher doses of CM (60-100 ml), the frequency of discomfort was significantly lower after iodixanol than after iohexol (p = 0.006). We conclude that, in intravenous urography, iodixanol provides at least as good image quality as does iohexol. Iodixanol may cause less discomfort than iohexol, in particular when larger volumes of CM are injected.
Petabit/s data center network architecture with sub-microseconds latency based on fast optical switches (2015)

We propose a novel flat Petabit/s optical DCN based on fast optical switching systems. Demonstration with 4×4 switch prototype shows dynamic switching operation at 40Gb/s with <;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> packet loss and 640ns latency with 0.4 load.
Supplementary Text from Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation (2023)

&lt;p&gt;PDF file - 151 KB, Supplemental text including supplemental methods, supplemental figure and table legends, and supplemental references.&lt;/p&gt;
Chimie douce: from shake-and-bake processing to wet chemistry (2001)

Wet chemistry methods known as “chimie douce” bring together organic and inorganic chemists. They offer new opportunities for the chemist’s imagination and lead to the synthesis of novel hybrid or bio-inspired materials.
<title>Raman studies as a tool for characterization of the strained hexagonal GaN/Al<formula><inf><roman>x</roman></inf></formula>Ga<formula><inf><roman>1-x</roman></inf></formula>N superlattices</title> (2002)

It is shown that such parameters of GaN/Al<sub>x</sub>Ga<sub>1-x</sub>N superlattice as the period, build-in strain, composition of the alloy, and individual layer thicknesses can be extracted from the energy positions, intensities, and line shapes of various optical and acoustical modes detected in Raman scattering.
FPGA based Passive Auto Focus System using Adaptive Thresholding (2006)

We present an FPGA based passive auto focus system which uses an adaptive thresholding to obtain well-focused images. Because the adaptive thresholding algorithm can evaluate the difference between each pixel and its neighborhoods, it can be applied to decide the specific area of an image contains high-frequency components or not. If the system decides a captured image has low-frequency components, the auto focus lens driver drives the lens until it obtains well-focused image. The algorithm we use is reasonably straightforward and does not require high computational power for real-time operation. The proposed system was implemented using FPGA and was successfully evaluated with a standard RS-170 video camera capturing 640 times 480 gray-level images at 30 frames per second with a 12.5-75mmF1.8TV lens
The mycotoxin factbook (2006)

Mycotoxins are poisonous chemical compounds produced by certain fungi. There are many such compounds, but only a few of them are regularly found in food and animal feedstuffs. Nevertheless, those that do occur in food and feed have great significance in the health of humans and livestock. effects of some mycotoxins are acute, with symptoms of severe illness appearing very quickly. Other mycotoxins have longer term chronic or cumulative effects on health, including the induction of cancers and immune deficiency. Information about mycotoxins is far from complete, but enough is known to identify them as a serious problem in many parts of the world, causing significant economic losses in addition to their negative health effects. The mycotoxin factbook is aimed at the latest developments to combat the mycotoxin problem. book contains the peer-reviewed papers of the third conference of the World Mycotoxin Forum. various chapters focus on mycotoxin food and feed risks in the context of human nutrition and animal feeding. Topics dealt with in The mycotoxin factbook are: regulatory issues, international developments and the impact on worldtrade; the latest information on major mycotoxins and emerging problems in the food chain; the impact of mycotoxins in the feed chain; new developments in mycotoxin prevention; and, trends in mycotoxin analysis. The mycotoxin factbook is a valuable resource for researchers and professionals from the food and feed industry as well as from the scientific community. This book is an ideal supplement to Meeting the mycotoxin menace as published in 2004.
Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells (2006)

A recent review article by Jänne et al. (1) begins with, “The polyamines, putrescine, spermidine, and spermine, are organic cations shown to participate in a bewildering number of cellular reactions, yet their exact functions in intermediary metabolism and specific interactions with cellular components remain largely elusive.” As documented by Schipper et al. (2) in their article entitled “Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors?” apoptosis or programmed cell death certainly belongs on the list. As the title of the Schipper et al. review indicates, the role of polyamines in apoptosis is anything but clear. In most, but not all instances, ornithine decarboxylase (ODC) activity increased with the induction of apoptosis, but there was no clear cut change in polyamine levels as they increased, decreased, or stayed the same depending on the system (2). Most experiments examining the effect of blocking ODC with α-difluoromethylornithine (DFMO) reported protection from apoptosis, whereas a few found no effect (2). The effects of polyamine analogs on apoptosis were also variable (2).
A new approach to interference suppression in spread-spectrum systems (2002)

The nonlinear filter derived by H.V. Poor and R. Vijayan (1988, 1990) is generalized to the case of channels corrupted by impulsive noise. The class of impulsive channels considered includes the Gaussian channel as a special case. The authors exploit the binary nature of the direct-sequence signals to obtain performance using nonlinear filters. A nonlinear modification of the transversal filter, with the coefficients being updated using the least mean square algorithm, is seen to perform significantly better than the standard adaptive linear filter. Further nonlinear modifications of the prediction filters are found for a variety of impulsive channel distribution shapes. It was found that the filters designed for the Gaussian channel perform as well as those tailored to the specific impulsive channels. As a result, the impulsive channels can be approximated by a Gaussian one with no loss in performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tunable Photoconductivity of Porous Anodic Aluminum Oxide with Silver Nanoparticles (2012)

The dielectric porous anodic aluminum oxide films (AAO) with embedded two-dimensional (2D) silver nanoparticles array (Ag/AAO) have been fabricated by electrochemical deposition. This substrate has the function of photo-induced conductivity which is attributed to plasmonic coupling among neighboring silver nanoparticles and can be applied to the optical switching. In this letter, we present the systemic analysis on the photo-induced conductivity of Ag/AAO films with different pore diameters and under different wavelength illuminations, and show the highly linearity between the photo-induced current and surface plasmon resonance of Ag/AAO films.
The asynchronous access etiquette for the 1910-1920 MHz and 2390-2400 MHz spectrum (2003)

The FCC has allocated two 10 MHz bands of spectrum (1910-1920 MHz and 2390-2400 MHz) for asynchronous unlicensed operation under a specific set of physical layer and media access layer constraints known as the asynchronous etiquette. Little information is available on the details of the performance of the etiquette. This paper provides a first-cut evaluation of the theoretical limits on the throughput and delay performance of the etiquette. The work studies, via simulation, the effects of propagation delays and hardware latencies. The simulation is calibrated by considering specific subcases for which simple analytic results are easily found. Numerical results illustrate the performance.
New insights into the mechanisms of the two way memory effect in copper based shape memory alloys (1994)

It is demonstrated that several generally accepted rules are not valid for samples showing the two way memory effect (TWME). The results, presented in this paper, confirm that the TWME is caused by the thermodynamic favouring of the martensitic variants which are repeatedly induced during training. New shape memory properties linked with this TWME-mechanism are discussed.
Reduced-Order Model Construction Procedure for Robust Mistuning Identification of Blisks (2008)

Peer Reviewed