gebhart/patrepeval huggingface dataset:
Genome-wide polygenic risk impact on intracranial aneurysms and acute ischemic stroke (2022)

Polygenic risk scores (PRSs) have an important relevance to approaches for clinical usage in intracranial aneurysm (IA) patients. Hence, we aimed to develop IA-predicting PRS models including the genetic basis shared with acute ischemic stroke (AIS) in Korean populations. We applied a weighted PRS (wPRS) model based on a previous genome-wide association study (GWAS) of 250 IA patients in a hospital-based multicenter cohort, 222 AIS patients in a validation study, and 296 shared controls. Risk predictability was analyzed by the area under the receiver operating characteristic curve (AUROC). The best-fitting risk models based on wPRSs were stratified into tertiles representing the lowest, middle, and highest risk groups. The weighted PRS, which included 29 GWASs (p < 5×10-8) and two reported genetic variants (p < 0.01), showed a high predictability in IA patients (AUROC = 0.949, 95% CI: 0.933-0.966). This wPRS was significantly validated in AIS patients (AUROC = 0.842, 95% CI: 0.808-0.876; p < 0.001). Two-stage risk models stratified into tertiles showed an increased risk for IA (OR = 691.25, 95% CI: 241.77-1976.35; p = 3.1×10-34; sensitivity/specificity = 0.728/0.963), which was replicated in AIS development (OR = 39.76, 95% CI: 16.91-93.49; p = 3.1×10-17; sensitivity/specificity = 0.284/0.963). A higher wPRS for IA may be associated with an increased risk of AIS in the Korean population. These findings suggest that IA and AIS may have a shared genetic architecture and should be studied further to generate a precision medicine model for use in personalized diagnosis and treatment.
Aperture formation on reduced-channel arrays using the transmit-receive apodization matrix (2002)

We present the transmit-receive apodization matrix (T/R matrix) as a tool for aperture synthesis on reduced-channel arrays. Reduced-channel arrays have a small number of transmit/receive channels multiplexed to a conventional dense array. For a 1D array of N elements, the T/R matrix is the N/spl times/N matrix of apodization values, where the rows correspond to transmit element positions and the columns correspond to receive element positions. We show that the round-trip beam pattern may be obtained from this matrix simply as the Fourier transform of its cross-diagonal sum. The aperture synthesis process consists of choosing the T/R matrix under certain constraints. If the T/R matrix has rank one, then a single transmit with parallel receive forms the beam (conventional case), and the round-trip beam can be separated into the product of the transmit beam and the receive beam. As the rank of the T/R matrix increases, greater beamforming flexibility is achieved, allowing for tradeoffs in SNR, frame-rate, and system complexity.
Autonomous mobility on demand in SimMobility: Case study of the central business district in Singapore (2015)

Autonomous mobility on demand (AMOD) has emerged as a promising solution for urban transportation. Compared to prevailing systems, AMOD promises sustainable, affordable personal mobility through the use of self-driving shared vehicles. Our ongoing research seeks to design AMOD systems that maximize the demand level that can be satisfactorily served with a reasonable fleet size. In this paper, we introduce an extension for SimMobility — a high-fidelity agent-based simulation platform — for simulating and evaluating models for AMOD systems. As a demonstration case study, we use this extension to explore the effect of different fleet sizes and stations locations for a station-based model (where cars self-return to stations) and a free-floating model (where cars self-park anywhere). Simulation results for evening peak hours in the Singapore Central Business District show that the free-floating model performed better than the station-based model with a “small number” of stations; this occurred primarily because return legs comprised “empty” trips that did not serve customers but contributed to road congestion. These results suggest that making use of distributed parking facilities to prevent congestion can improve the overall performance of an AMOD system during peak periods.
Interactions between biological and abiotic pathways in the reduction of chlorinated solvents (2009)

Abstract While biologically mediated reductive dechlorination continues to be a significant focus of chlorinated solvent remediation, there has been an increased interest in abiotic reductive processes for the remediation of chlorinated solvents. In situ chemical reduction (ISCR) uses zero‐valent iron (ZVI)–based technologies, such as nanoscale iron and bimetallic ZVI, as well as naturally occurring reduced minerals incorporating dual‐valent iron (DVI), such as magnetite, green rust, and iron sulfides that are capable of dechlorinating solvents. A more recent area of development in ISCR has been in combining biological and abiotic processes. There are several ways in which biological and abiotic processes can be combined. First, the interaction between the two may be “causative.” For example, the Air Force Center for Engineering and the Environment's biogeochemical reductive dechlorination (BiRD) technology combines a mulch barrier with hematite and gypsum to create an iron‐sulfide‐based reducing zone. Biodegradation under sulfate‐reducing conditions produces sulfide that combines with the hematite to form iron sulfides. As such, the BiRD technology is “causative”; the biological processes create reducing minerals. The biological generation of other reducing minerals such as magnetite, siderite, and green rust is feasible and is, with magnetite, observed in nature at some petroleum sites. A second type of interaction between abiotic and biotic processes is “synergistic.” For example, biological processes can enhance the activity of reduced metals/minerals. This is the basis of the EHC® ISCR technologies, which combine ZVI with a (slowly) degradable carbon substrate. This combination rapidly creates buffered, strongly reducing conditions, which result in more complete solvent degradation (i.e., direct mineralization). The extent and level of reducing activity commonly observed are much greater when both the carbon substrate and the ZVI are present. When the carbon substrate is expended, the reducing activity due to ZVI alone is much less. The understanding of biogeochemical processes and their impact on abiotic processes is still developing. As that understanding develops, new and improved methods will be created to enhance volatile organic compound destruction. © 2009 Wiley Periodicals, Inc.
A 0.18-.MU.m CMOS X-Band Shock Wave Generator with an On-Chip Dipole Antenna and a Digitally Programmable Delay Circuit for Pulse Beam-Formability (2011)

In this paper, we present a 0.18-µm CMOS fully integrated X-band shock wave generator (SWG) with an on-chip dipole antenna and a digitally programmable delay circuit (DPDC) for pulse beam-formability in short-range and hand-held microwave active imaging applications. This chip includes a SWG, a 5-bit DPDC and an on-chip wide-band meandering dipole antenna. By using an integrated transformer, output pulse of the SWG is sent to the on-chip meandering dipole antenna. The SWG operates based on damping conditions to produce a 0.4-V peak-to-peak (p-p) pulse amplitude at the antenna input terminals in HSPICE simulation. The DPDC is designed to adjust delays of shock-wave outputs for the purpose of steering beams in antenna array systems. The wide-band dipole antenna element designed in the meandering shape is located in the top metal of a 5-metal-layer 0.18-µm CMOS chip. By simulating in Momentum of ADS 2009, the minimum value of antenna's return loss, S11, and antenna's bandwidth (BW) are -19.37dB and 25.3GHz, respectively. The measured return loss of a stand-alone integrated meandering dipole is from -26dB to -10dB with frequency range of 7.5-12GHz. In measurements of the SWG with the integrated antenna, by using a 20-dB standard gain horn antenna placed at a 38-mm distance from the chip's surface, a 1.1-mVp-p shock wave with a 9-11-GHz frequency response is received. A measured 3-ps pulse delay resolution is also obtained. These results prove that our proposed circuit is suitable for the purpose of fully integrated pulse beam-forming system.
Oxidative addition of oxygen-hydrogen bonds to iridium(I): synthesis and characterization of (phenolato)- and (carboxylato)iridium(III) hydride complexes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative addition of oxygen-hydrogen bonds to iridium(I): synthesis and characterization of (phenolato)- and (carboxylato)iridium(III) hydride complexesFolami T. Ladipo, Mahimid Kooti, and Joseph S. MerolaCite this: Inorg. Chem. 1993, 32, 9, 1681–1688Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ic00061a025https://doi.org/10.1021/ic00061a025research-articleACS PublicationsRequest reuse permissionsArticle Views510Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Review: Gunboat Frontier: British Maritime Authority and Northwest Coast Indians, 1846-1890, by Barry M. Gough (1985)

Book Review| August 01 1985 Review: Gunboat Frontier: British Maritime Authority and Northwest Coast Indians, 1846-1890, by Barry M. Gough Gunboat Frontier: British Maritime Authority and Northwest Coast Indians, 1846-1890Barry M. Gough Douglas Cole Douglas Cole Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1985) 54 (3): 361–362. https://doi.org/10.2307/3639642 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Douglas Cole; Review: Gunboat Frontier: British Maritime Authority and Northwest Coast Indians, 1846-1890, by Barry M. Gough. Pacific Historical Review 1 August 1985; 54 (3): 361–362. doi: https://doi.org/10.2307/3639642 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1985 The Pacific Coast Branch, American Historical Association Article PDF first page preview Close Modal You do not currently have access to this content.
Multiscale Modelling of UniMolecular FRET Probes Using Monte Carlo Simulations (2015)

Föster Resonance Energy Transfer (FRET) based biosensors are widely used in experimental biology to understand spatiotemporal dynamics of protein pairs both in-vivo and in-vitro. In our study we have developed an idealised model consisting of two macroparticles, representing proteins attached to fluorescent chromophores, linked with an idealized flexible linker consisting of N point-like beads joined by harmonic springs. Monte Carlo simulations with these models are used to investigate the influence of flexible linkers on unimolecular FRET based bio-sensors. The results provide qualitative insight into the efficacy of designing flexible peptide linkers.
Crystallization in Poly(l-lactide)-b-poly(ε-caprolactone) Double Crystalline Diblock Copolymers:  A Study Using X-ray Scattering, Differential Scanning Calorimetry, and Polarized Optical Microscopy (2004)

The crystallization of well-defined poly(l-lactide)-b-poly(ε-caprolactone) diblock copolymers, PLLA-b-PCL, was investigated by time-resolved X-ray techniques, polarized optical microscopy (POM), and differential scanning calorimetry (DSC). Two compositions were studied that contained 44 and 60 wt % poly(l-lactide), PLLA (they are referred to as L4411C5614 and L6012C409, respectively, with the molecular weight of each block in kg/mol as superscript). The copolymers were found to be initially miscible in the melt according to small-angle X-ray scattering measurements (SAXS). Their thermal behavior was also indicative of samples whose crystallization proceeds from a mixed melt. Sequential isothermal crystallization from the melt at 100 °C (for 30 min) and then at 30 °C (for 15 min) was measured. At 100 °C only the PLLA block is capable of crystallization, and its crystallization kinetics was followed by both WAXS and DSC; comparable results were obtained that indicated an instantaneous nucleation with three-dimensional superstructures (Avrami index of approximately 3). The spherulitic nature of the superstructure was confirmed by POM. When the temperature was decreased to 30 °C, the PCL block was able to crystallize within the PLLA negative spherulites (with an Avrami index of 2, as opposed to 3 in homo-PCL), and its crystallization rate was much slower than an equivalent homo-PCL. Time-resolved SAXS experiments in L6012C409 revealed an initial melt mixed morphology at 165 °C that upon cooling transformed into a transient microphase-separated lamellar structure prior to crystallization at 100 °C.
Reorganization and Expression of Immunoglobulin Genes: Status of Allelic Elements (1981)

The formation of productive genes for light-chain and heavy-chain immunoglobulins involves site-specific recombinations of the germ-line DNA. These recombinations result in deletions that juxtapose particular variable (V)-region genes to joining (J) elements located upstream from the constant (C)-region genes (Max et al. 1979; Sakano et al. 1979). In the case of heavy chains, subsequent deletions within the multiple CH gene cluster can result in a switch from one immunoglobulin class to another (Honjo and Kataoka 1978; Coleclough et al. 1980; Cory et al 1980; Rabbitts et al. 1980). Although lymphoid cells are diploid, only one set of immunoglobulin alleles are normally expressed, as judged by the production of complete, functional light or heavy chains (Pernis et al. 1965; Weiler 1965). To elucidate the molecular basis of this phenomenon, one must have a clear understanding of how immunoglobulin gene organization and immunoglobulin expression are related and have an accurate description of...
Cytological identity of 93D-like and 87C-like heat shock loci in Drosophila pseudoobscura (1984)

The 2-58C heat shock locus of D. pseudoobscura is specifically inducible by benzamide and colchicine. The present results, together with all earlier report, show that this heat shock locus is homologus to 93D as well as to 87C of D. melanogaster.
Prognostic and predictive role of a metabolic rate‐limiting enzyme signature in hepatocellular carcinoma (2021)

Our results highlighted the prognostic value of rate-limiting enzymes in HCC, which may be useful for accurate risk assessment in guiding clinical management and treatment decisions.
Reducing the inductance requirements of piezoelectric shunt damping systems (2003)

Structural vibration can be reduced by shunting an attached piezoelectric transducer (PZT) with an electrical impedance. Current shunt circuit designs, e.g. a single-mode inductor–resistor network, typically require large inductance values of up to thousands of henries. In practice, discrete inductors are limited in size to around 1 H. By placing an additional capacitance across the terminals of the PZT, shunt circuit inductances can be drastically reduced. To justify our claims, we present a theoretical analysis of the damped system and identify the influence of the additional capacitance. Two modes of a simply supported beam are successfully damped using a capacitance modified shunt circuit. A low inductance multi-mode circuit is also studied and experimentally verified.
Design and Performance of the mDOM Mainboard for the IceCube Upgrade (2023)

About 400 mDOMs (multi-PMT Digital Optical Modules) will be deployed as part of the IceCube Upgrade Project. The mDOM’s high pressure-resistant glass sphere houses 24 PMTs, 3 cameras, 10 flasher LEDs and various sensors. The mDOM mainboard design was challenging due to the limited available volume and demanding engineering requirements, like the maximum overall power consumption, a minimum trigger threshold of 0.2 photoelectrons (PE), the dynamic range and the linearity requirements. Another challenge was the FPGA firmware design, dealing with about 35 Gbit/s of continuous ADC data from the digitization of the 24 PMT channels, the control of a high speed dynamic buffer and the discriminator output sampling rate of about 1GSPS. High-speed sampling of each of the discriminator outputs at ~1 GSPS improves the leading-edge time resolution for the PMT waveforms. An MCU (microcontroller unit) coordinates the data taking, the data exchange with the surface and the sensor readout. Both the FPGA firmware and MCU software can be updated remotely. After discussing the main hardware blocks and the analog frontend (AFE) design, test results will be shown, covering especially the AFE performance. Additionally, the functionality of various sensors and modules will be evaluated.
Microwave study of the high-TcsuperconductorLa1.8Sr0.2CuO4 (1987)

High-${T}_{c}$ superconductivity is investigated by a microwave-cavity perturbation technique in the compound ${\mathrm{La}}_{1.8}$${\mathrm{Sr}}_{0.2}$Cu${\mathrm{O}}_{4}$. Both the microwave loss and frequency shift show a rapid decrease at 39 K, the onset of the superconducting transition. A significant microwave absorption is also observed well below the transition. The data are used to determine the sample resistivity in the normal state and characterize the superconducting transition in an applied magnetic field.
Removing motion blur from barcode images (2010)

Camera shake during photography is a common problem which causes images to get blurred. Here we choose a specific problem in which the image is a barcode and the motion can be modeled as a convolution. We design a blind deconvolution algorithm to remove the translatory motion from a blurred barcode image. Based on the bimodal characteristics of barcode image histograms, we construct a simple target function that measures how similar a deconvoluted image is to a barcode. We minimize this target function over the set of possible convolution kernels to find the most likely blurring kernel. By restricting our search to dome-shaped kernels (first monotonously increasing and then monotonously decreasing) we decrease the number of false solutions. We have tried our system on a collection of a 138 barcode images with varying camera blur, and the recognition rate increases from 32% to 65%.
Evaluation of flecainide acetate in rapid atrial fibrillation complicating wolff‐parkinson‐white syndrome (1985)

Flecainide is reported to be effective in patients with paroxysmal tachycardias, but its effect on rapid ventricular response over accessory atrioventricular pathway during atrial fibrillation is not known. The influence of flecainide on various electrophysiological properties of the accessory pathway with special emphasis on ventricular rate during atrial fibrillation was investigated in 9 patients with severe symptomatic Wolff-Parkinson-White syndrome. The shortest ventricular response during atrial fibrillation increased from 218 (190-270) to 320 (240-block) ms. In 4 patients sustained rapid atrial fibrillation converted to sinus rhythm. The rate of circus movement tachycardia decreased from 166/min to 130/min after flecainide, due to a lengthening of retrograde ventriculoatrial conduction time over the accessory pathway. Flecainide caused a significant prolongation of the effective refractory period of the accessory pathway in our subgroup with extremely fast AV conduction during atrial fibrillation and induced a depressant effect on retrograde accessory pathway conduction. This makes the drug very promising for the emergency treatment of dangerous rapid tachyarrhythias complicating this syndrome.
Studying the extremes: hydrometeorological investigation of a flood-causing rainstorm over Israel (2007)

Abstract. Analysis of extreme hydrometeorological events is important for characterizing and better understanding the meteorological conditions that can generate severe rainstorms and the consequent catastrophic flooding. According to several studies (e.g., Alpert et al., 2004; Wittenberg et al., 2007), the occurrence of such extreme events is increasing over the eastern Mediterranean although total rain amounts are generally decreasing. The current study presents an analysis of an extreme event utilizing different methodologies: (a) synoptic maps and high resolution satellite imagery for atmospheric condition analysis; (b) rainfall analysis by rain gauges data; (c) meteorological radar rainfall calibration and analysis; (d) field measurements for estimating maximum peak discharges; and, (e) high resolution aerial photographs together with field surveying for quantifying the geomorphic impacts. The unusual storm occurred over Israel between 30 March and 2 April, 2006. Heavy rainfall produced more than 100 mm in some locations in only few hours and more than 200 mm in the major core area. Extreme rain intensities with recurrence intervals of more than 100 years were found for durations of 1 h and more as well as for the daily rain depth values. In the most severely affected area, Wadi Ara, extreme flash floods caused damages and casualties. Specific peak discharges were as high as 10–30 m³/s/km² for catchments of the size of 1–10 km², values larger than any recorded floods in similar climatic regions in Israel.
eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications (2007)

Authors, editors and reviewers alike use the biomedical literature to identify appropriate journals in which to publish, potential reviewers for papers or grants, and collaborators (or competitors) with similar interests. Traditionally, this process has either relied upon personal expertise and knowledge or upon a somewhat unsystematic and laborious process of manually searching through the literature for trends. To help with these tasks, we report three utilities that parse and summarize the results of an abstract similarity search to find appropriate journals for publication, authors with expertise in a given field, and documents similar to a submitted query. The utilities are based upon a program, eTBLAST, designed to identify similar documents within literature databases such as (but not limited to) MEDLINE. These services are freely accessible through the Internet at http://invention.swmed.edu/etblast/etblast.shtml, where users can upload a file or paste text such as an abstract into the browser interface.