gebhart/patrepeval huggingface dataset:
Factors Predictive of Quality of Life after Silicone-Implant Explantation (1999)

'Medical records of 180 patients who underwent silicone gel-filled breast implant explanation were retrospectively reviewed. The goal of this study was to determine if any patient variable(s) had predictive value for positive quality of life after explanation. The medical complaints, symptoms, and established diagnoses were considered equally and were referred to as self-reported medical problems. The study revealed that no single problem or pairing of problems was associated with or predictive of outcome. The results show, however, that the number of medical problems was significantly predictive of patient perception of quality of life. A total of 50 explanation patients completed quality-of-life surveys. Specifically, those patients who reported five or fewer medical problems that predated explantation were significantly more likely to perceive an increased quality of life after surgery than those who reported nine or more medical problems (p < 0.04). In conclusion, it is difficult to correlate subjective patient symptoms with postoperative improvements in quality of life after explantation.
Diffusion weighted MRI as an early predictor of tumor response to hypofractionated stereotactic boost for prostate cancer (2018)

We evaluated the feasibility of using the kinetic of diffusion-weighted MRI (DWI) and the normalized apparent coefficient diffusion (ADC) map value as an early biomarker in patients treated by external beam radiotherapy (EBRT). Twelve patients were included within the frame of a multicenter phase II trial and treated for intermediate risk prostate cancer (PCa). Multiparametric MRI was performed before treatment (M0) and every 6 months until M24. Association between nADC and PSA or PSA kinetic was evaluated using the test of nullity of the Spearman correlation coefficient. The median rates of PSA at the time of diagnosis, two years and four years after EBRT were 9.29 ng/ml (range from 5.26 to 17.67), 0.68 ng/ml (0.07-2.7), 0.47 ng/ml (0.09-1.39), respectively. Median nADC increased from 1.14 × 10<sup>-3</sup> mm<sup>2</sup>/s to 1.59 × 10<sup>-3</sup> mm<sup>2</sup>/s between M0 and M24. Only one patient presented a decrease of nADC (1.35 × 10<sup>-3</sup> mm<sup>2</sup>/s and 1.11 × 10<sup>-3</sup> mm<sup>2</sup>/s at M0 and M12 respectively). The increase in nADC at M6 was correlated with PSA decrease at M18, M24 and M30 (p < 0.05). The increase in nADc at M12 was correlated with PSA decrease at M36 (p = 0.019). Early nADC variation were correlated with late PSA decrease for patients with PCa treated by EBRT.
Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects (2016)

<sup>18</sup>F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are implicated in neurologic disorders including Alzheimer disease and traumatic brain injury (TBI). The current study characterizes <sup>18</sup>F-T807 pharmacokinetics in human subjects using dynamic PET imaging and metabolite-corrected arterial input functions. <b>Methods:</b> Nine subjects (4 controls, 3 with a history of TBI, 2 with mild cognitive impairment due to suspected Alzheimer disease) underwent dynamic PET imaging for up to 120 min after bolus injection of <sup>18</sup>F-T807 with arterial blood sampling. Total volume of distribution (<i>V</i><sub>T</sub>) was estimated using compartmental modeling (1- and 2-tissue configurations) and graphical analysis techniques (Logan and multilinear analysis 1 [MA1] regression methods). Reference region-based methods of quantification were explored including Logan distribution volume ratio (DVR) and static SUV ratio (SUVR) using the cerebellum as a reference tissue. <b>Results:</b> The percentage of unmetabolized <sup>18</sup>F-T807 in plasma followed a single exponential with a half-life of 17.0 ± 4.2 min. Metabolite-corrected plasma radioactivity concentration fit a biexponential (half-lives, 18.1 ± 5.8 and 2.4 ± 0.5 min). <sup>18</sup>F-T807 in gray matter peaked quickly (SUV > 2 at ∼5 min). Compartmental modeling resulted in good fits, and the 2-tissue model with estimated blood volume correction (2Tv) performed best, particularly in regions with elevated binding. <i>V</i><sub>T</sub> was greater in mild cognitive impairment subjects than controls in the occipital, parietal, and temporal cortices as well as the posterior cingulate gyrus, precuneus, and mesial temporal cortex. High focal uptake was found in the posterior corpus callosum of a TBI subject. Plots from Logan and MA1 graphical methods became linear by 30 min, yielding regional estimates of <i>V</i><sub>T</sub> in excellent agreement with compartmental analysis and providing high-quality parametric maps when applied in voxelwise fashion. Reference region-based approaches including Logan DVR (<i>t</i>* = 55 min) and SUVR (80- to 100-min interval) were highly correlated with DVR estimated using 2Tv (<i>R</i><sup>2</sup> = 0.97, <i>P</i> < 0.0001). <b>Conclusion:</b><sup>18</sup>F-T807 showed rapid clearance from plasma and properties suitable for tau quantification with PET. Furthermore, simplified approaches using DVR (<i>t</i>* = 55 min) and static SUVR (80-100 min) with cerebellar reference tissue were found to correlate highly with compartmental modeling outcomes.
High-yield expression in Escherichia coli of soluble human α-hemoglobin complexed with its molecular chaperone (2006)

The alpha-subunits of human hemoglobin (Hb) have been more difficult to express than beta-chains owing to the high instability of alpha-chains. Here, we describe the production in Escherichia coli of a soluble recombinant alpha-Hb with human alpha-hemoglobin-stabilizing protein (AHSP), its molecular chaperone. To succeed in this expression, we have constructed a vector pGEX-alpha-AHSP which contains two cassettes arranged in tandem in the same orientation permitting to express alpha-hemoglobin and human AHSP. While the GST-alpha-Hb alone was expressed in E.coli as insoluble protein, even after adding lysate containing recombinant AHSP, the expression vector pGEX-alpha-AHSP permits the co-expression of soluble GST-alpha-Hb and GST-AHSP. The alpha-Hb, produced at a high yield of 12 to 20 mg per liter of culture, was then purified as a complex with its chaperone. Biochemical and biophysical properties of recombinant AHSP/recombinant alpha-Hb complex were similar to those of recombinant AHSP/native alpha-Hb complex as assessed by UV/visible and CO or O(2) binding properties. This co-expression technique can be use to study the interaction between a molecular chaperone and its target protein and, more generally, this system would be particularly interesting for the study of partner proteins when one or both proteins are individually unstable.
Magnetometer-detected Nuclear Magnetic Resonance of Photochemically Hyperpolarized Molecules (2023)

Photochemically induced dynamic nuclear polarization (photo-CIDNP) enables nuclear spin ordering by irradiating samples with light. Polarized spins are conventionally detected via high-field chemical shift-resolved NMR (above 0.1 T), however, of particular importance are CIDNP processes occurring at relatively low fields (<50 mT). In this paper, we demonstrate in situ low-field photo-CIDNP measurements using shielded fast-field-cycling NMR combined with audio-frequency detection of Larmor precession via atomic magnetometers. A model system is used comprising tetraphenyl porphyrin as a photosensitizer, and 1,4-benzoquinone as a quencher. For solutions comprising sub-mM concentrations of the photosensitizer and mM concentrations of the quencher, hyperpolarized 1H magnetization is detected by pulse-acquire NMR spectroscopy at 170 nT and 2 μT fields. The observed NMR linewidths are about 5 times narrower than normally anticipated in high-field NMR and are systematically affected by light irradiation during the acquisition period, reflecting a reduction of the transverse relaxation time constant, T_{2}*. Magnetometer-detected photo-CIDNP spectroscopy enables straightforward observation of spin-chemistry processes in the ambient field range of a few nT to tens of mT and may help resolve open questions regarding the nature of avian magneto sensing.
CMOS-Compatible Ti/TiN/Al Refractory Ohmic Contact for GaAs Heterojunction Bipolar Transistors Grown on Ge/Si Substrate (2021)

In this article, we demonstrate the Ti/TiN/Al (15/50/50 nm) ohmic contact on InGaP/GaAs heterojunction bipolar transistors (HBTs) epitaxially grown on 200-mm Si substrate. We study the rapid thermal annealing (RTA) effect of the metal stack on both n-type InGaAs and p-type GaAs. The dc characteristics of the HBT devices fabricated using the Ti/TiN/Al metal contacts have been analyzed. Contact resistances <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${(}{R}_{c}{)} &lt; 0.1~\Omega \cdot $ </tex-math></inline-formula> mm for n-InGaAs and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$0.8~\Omega \cdot $ </tex-math></inline-formula> mm for p-GaAs can be achieved. A dc current gain of 45 with a collector–base breakdown voltage (BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">cbo</sub> ) of 15.65 V is achieved. The ideality factor of the emitter–base current ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${n}_{b}$ </tex-math></inline-formula> ) and base–collector current ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${n}_{c}$ </tex-math></inline-formula> ) is 1.03 and 1.44, respectively, after RTA at 450 °C. The dc characteristics remain stable upon prolonged annealing at 450 °C for 45 min. This high thermal budget non-gold ohmic contact is suitable for Si-CMOS integration and enables the potential for hybrid III-V CMOS technology for 5G and mm-wave applications.
Cellular electrophysiological effects of hyperthermia on isolated guinea pig papillary muscle. Implications for catheter ablation. (1993)

Hyperthermia causes significant changes in myocardial cellular electrophysiological properties that include membrane depolarization, reversible and irreversible loss of excitability, and abnormal automaticity. There appear to be specific temperature ranges for reversible and irreversible electrophysiological changes. These observations may have important implications for tissue temperature monitoring during radiofrequency catheter ablation.
Using Morphogenetic Models to Develop Spatial Structures (2011)

A common problem in spatial computing is how to arrange the structure of a spatial computer into a geometric form adapted for its current environment and needs. In natural biological organisms, the processes of morphogenesis adapt structure to environment remarkably well on both an individual and evolutionary time scale. However, no clear framework has been developed for exploiting morphogenetic principles in the creation of engineered systems. In this paper, we present preliminary work toward such a framework, developed against the example of a robot similar to the iRobot LANdroid. We first show how developmental programs might act as a reference architecture for engineered designs, facilitating variation. We then present a candidate basis set of geometric operations for encoding adaptable developmental programs, demonstrate how they can be applied to develop a robot body plan, and discuss progress toward implementation.
Growth Characteristics and Phenol Compounds Analysis of Collected Perilla frutescens Resources From China and Japan (2015)

This study was conducted to find out the variation in agronomic trait and chemical composition in the collected Perilla frutescens from China and Japan. From the results of growth investigation, the maximum number if branches was 26.7ea in Japan 134 line, followed by 25 nodes number in China 119 line. Among the different lines investigated, maximum number of panicle number (108.8) were observed in China 114 line. 1000 seed weight was maximum (4.12 g) in China 118 line. Flowering time of different collected lines varied significantly with average value of 175.5 days and the average line required for maturation of seedlings was 205.1 days. Plant height was the highest (248.9 ㎝) in China 107 line. Highest number of total picking leaves was 965ea, and the average picked period was 54 days. The major phenol compounds contained in Perilla frutescens showed wide variation for Syringic acid, Benzoic acid, Naringin, o-Coumaric acid, Myricetin, Naringenin and Hesperetin. Japan 139 line showed the highest level of total phenol contents (8254.0 ㎍/g, dry weight).
Classification and geographical distribution of Leymus in China (2005)

A new key of species of Leymus in China is presented which includes 3 sectio-ns 20 species and 2 varieties. Sect. Racemosus comprises 2 species, sect. Leymus comprises 15 species and sect. Anisopyrum comprises 3 species. Among these taxa, sect. Racemosus were described as new. In addition, the geographical distribution of Leymus in China was also reported. According to analysis and statistics, we speculate that the Altai region is the distribution center of Leymus in China.
Targeting Dynamic Compilation for Embedded Environments (2001)

Abstract : A generally held notion is that high quality code comes with high compilation cost. As a result, previous efforts at minimizing dynamic compilation costs have focused on designing fast, lightweight compilers that sacrifice code quality for compilation speed, and resource intensive approaches that combine multiple engines to limit expensive optimizations to critical sections. In this paper, we show one possible way fast compilers can be constructed to generate high quality code. We have implemented microJIT, a small and portable just-in-time (JIT) compiler for Java that can produce high quality code 2.5x faster than a comparable dataflow-based compiler and 30% faster than a compiler that performs only limited optimizations. We use dataflow techniques, but speed up compilation by minimizing the number of major compiler passes given the number of optimizations performed. Architectural features of our compiler also allow it to perform instruction set dependent optimizations efficiently. MicroJIT achieves these high compilation rates while still maintaining small static and dynamic memory requirements. This compiler can be highly effective in an embedded system where computing and memory resources are highly constrained and where multiple target platforms must be supported.
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome (2018)

Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members (PLCB4 added to previously reported PLCE1), related to inflammation of blood vessels. For dengue fever (DF), we found evidence of significant association with CHST10, AHRR, PPP2R5E and GRIP1 genes, which participate in the xenobiotic metabolism signaling pathway. We conducted functional analyses for PPP2R5E, revealing by immunofluorescence imaging that the coded protein co-localizes with both DENV1 and DENV2 NS5 proteins. Interestingly, only DENV2-NS5 migrated to the nucleus, and a deletion of the predicted top-linking motif in NS5 abolished the nuclear transfer. These observations support the existence of differences between serotypes in their cellular dynamics, which may contribute to differential infection outcome risk. The contribution of the identified genes to the genetic risk render Southeast and Northeast Asian populations more susceptible to both phenotypes, while African populations are best protected against DSS and intermediately protected against DF, and Europeans the best protected against DF but the most susceptible against DSS.
A Note on the Spinned Poisson Distribution (2013)

Recently a new probability distribution, the spinned Poisson distribution\n(SPD), was introduced to model data collected in various health management\nsituations, such as the spread of an infectious disease when infected cases are\nremoved from the observed population. As the name suggests, the SPD is a\ngeneralization of the well known Poisson distribution. In this paper, simple\ndata sets are used to show that there is no guarantee that the equations for the\nmaximum likelihood estimates of the parameters associated with the SPD have a\nnontrivial solution. It follows that even for a simple data set where a\nnontrivial SPD may seem appropriate, the fitted SPD may be just a Poisson\ndistribution.
A Hand-Held Indentation System for the Assessment of Mechanical Properties of Soft Tissues In Vivo (2009)

Quantitative assessment of the mechanical properties of soft tissues <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> is required in both clinical and research fields. This paper introduces a hand-held indentation system that employed an electromagnetic spatial sensor as a displacement transducer. The system was pen-sized, portable, and easy to control. The accuracy and reliability of the system were investigated. The effect of indentation rate on the variation of the values of the measured effective Young's modulus was also studied. A series of elastomers with different Young's modulus (which ranged from 13.08 to 36.19 kPa) were assessed with both the hand-held indentation system and a Hounsfield material testing machine. Intraindividual and interindividual variations of the system were tested by five independent operators. The hand-held indentation system was applied to quantitatively assess the effective Young's modulus of human body parts <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> . Twenty healthy female subjects aged 21.1 plusmn 1.8 years old were included for the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> test. The system was shown to be highly accurate ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</i> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.99) compared with the results obtained by the mechanical testing machine and had good reliability (intraindividual variation = 5.43%, and interindividual variation = 5.99%). The average effective Young's moduli of the region of umbilicus were 11.31 and 12.65 kPa for two different sites, respectively. It is believed that this hand-held indentations system was an accurate reliable tool for rapidly assessing the mechanical properties of human body tissues <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> .
A novel anti‐hypertensive peptide derived from ovalbumin induces nitric oxide‐mediated vasorelaxation in an isolated SHR mesenteric artery (1999)

In this report, we deal with the isolation of a novel vasorelaxing peptide from a chymotryptic digest of ovalbumin and its vasorelaxing activities. This peptide is composed of Arg-Ala-Asp-His-Pro-Phe (RADHPF) in its sequence, corresponding to residues 359-364 of ovalbumin. This peptide (30-300 microM) exerted a dose-dependent vasodilation in an isolated mesenteric artery from a spontaneously hypertensive rat which was pre-constricted by phenylephrine, besides the relaxation being endothelium-dependent. It is noteworthy that the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester inhibited this relaxation, implying involvement of nitric oxide in its mechanism of action. Following oral administration of RADHPF at a dose of 10 mg/kg, the systolic blood pressure in a spontaneously hypertensive rat was significantly lowered.
Output distributions of stack filters based on mirrored threshold decomposition (2001)

The output distribution formula for stack filters based on mirrored threshold decomposition is derived. This formula allows one to compute the cumulative distribution function of the output of a stack filter for a given independent and identically distributed (i.i.d.) input noise distribution. Mirrored threshold decomposition permits us to analyze the input-output characteristics of the stack filter in the binary domain. The sliding window operation of the stack filter is modeled by a deterministic finite automaton. The output distribution of the filter is obtained by interpreting the automaton as a Markov chain whose transition probabilities depend on the probabilistic description of the binary input signal. An example illustrating the use of the output distribution formula is provided.
Transmission schemes for millimeter-wave radio-over-fiber system using remote and local heterodyning of free-running lasers and self-homodyning RF receiver (2011)

Two radio-over-fiber data transmission schemes are demonstrated in which the millimeter-wave carrier is generated by heterodyning two free-running DFB lasers, and detected by self-homodyning at receiver. The system is relatively simple and cheap to implement.
Series Editorial: Inauguration Issue of the Series on Machine Learning in Communications and Networks (2020)

In the era of the new generation of communication systems, data traffic is expected to continuously strain the capacity of future communication networks. Along with the remarkable growth in data traffic, new applications, such as wearable devices, autonomous systems, and the Internet of Things (IoT), continue to emerge and generate even more data traffic with vastly different requirements. This growth in the application domain brings forward an inevitable need for more intelligent processing, operation, and optimization of future communication networks.
Study of cell‐free protein synthesis in aqueous two‐phase systems (1995)

Protein synthesis in an aqueous two-phase system is reported here as a novel type of extractive bioconversion. Translation of BMV RNA was studied using either rabbit reticulocyte lysate or wheat-germ extract in aqueous dextran-PEG systems. Both polymers inhibited protein synthesis and the translation system partitioned into both phases. In the rabbit reticulocyte two-phase system, protein synthesis reached 30% of that in free solution, while in wheat-germ extract it was 60% of that in free solution. Protein was found mainly in the dextran (lower) phase but its partitioning was related to the polymer concentration, and molecular weight, as well as the ionic strength of the system. Protein synthesis was highly influenced by PEG concentration, potassium chloride concentration, and dextran molecular weight.