gebhart/patrepeval huggingface dataset:
Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer (2017)

Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels. In vitro cellular assays showed that multifunctional targeting epirubicin liposomes not only exhibited the strongest cytotoxic effect on Lewis lung tumor cells but also showed the most efficient inhibition on VM channels. Action mechanism studies showed that multifunctional targeting epirubicin liposomes could downregulate PI3K, MMP-2, MMP-9, VE-Cadherin, and FAK and activate apoptotic enzyme caspase 3. In vivo results exhibited that multifunctional targeting epirubicin liposomes could accumulate selectively in tumor site and display an obvious antitumor efficacy. In addition, no significant toxicity of blood system and major organs was observed at a test dose. Therefore, multifunctional targeting epirubicin liposomes may provide a safe and efficient therapy strategy for NSCLC.
Personal Health Explorer: A Semantic Health Recommendation System (2012)

This paper introduces the concept, design, and implementation of the Personal Health Explorer (PHE), a semantic recommender system that allows an individual to perform semantic search and discovery related to conditions and diseases contained in his personal health record. The PHE system consults authoritative ontologies and reputable information sources to provide semantically enhanced recommendations that can be stored in the individual's personal health record for further research and consultation. The PHE is implemented using the Knowledge Sifter agent-based framework and Microsoft's HealthVault.
Combinatorial Particle Patterning by Nanoxerography (2018)

Abstract In their article ( https://doi.org/10.1002/adfm.201703511 ), Bojnicic‐Kninski et al. expose the known methods used for creating, on a same substrate, patterns composed of different types of particles. This approach is called “combinatorial particle patterning.” They describe various techniques and group them depending on the used methods or driving forces that enable the directed assemblies of particles. A substantial part of the article (Part 2: Electrical Particle Patterning) referred to particle assemblies guided by electrostatic forces, i.e., electrophoretic or dielectrophoretic forces. However, this part, especially the paragraph on “Nanoxerography” (cf. 2.2 of the article) suffers from some inaccuracies that lead to partially wrong conclusions regarding combinatorial particle patterning. The goal of this comment is double: i) giving a complete and up to date definition of nanoxerography ii) reporting the results on combinatorial particle patterning using nanoxerography to correct the article inaccuracies.
Lifting Assembly to Intermediate Representation (2016)

Translating low-level machine instructions into higher-level intermediate language (IL) is one of the central steps in many binary analysis and instrumentation systems. Existing systems build such translators manually. As a result, it takes a great deal of effort to support new architectures. Even for widely deployed architectures, full instruction sets may not be modeled, e.g., mature systems such as Valgrind still lack support for AVX, FMA4 and SSE4.1 for x86 processors. To overcome these difficulties, we propose a novel approach that leverages knowledge about instruction set semantics that is already embedded into modern compilers such as GCC. In particular, we present a learning-based approach for automating the translation of assembly instructions to a compiler's architecture-neutral IL. We present an experimental evaluation that demonstrates the ability of our approach to easily support many architectures (x86, ARM and AVR), including their advanced instruction sets. Our implementation is available as open-source software.
PscI is a type III secretion needle anchoring protein with in vitro polymerization capacities. (2015)

International audience
Chemical Composition and Antibacterial Activity of the Essential Oil of Kauri Pine [Agathis robusta(C. Moore ex F. Muell.) F.M. Bailey] from India (2016)

Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey, commonly known as Queensland Kauri or smooth-barked Kauri, is a coniferous tree in the family Araucariaceae. This study aimed to investigate the chemical composition and antibacterial activity of the essential oil of A. robusta from India. The hydrodistilled resin and leaf essential oils were analyzed using GC-FID and GC-MS. Altogether, 34 constituents (forming 98.2% of the resin oil) and 43 constituents (forming 91.2% of the leaf oil composition) were identified. Major constituents of the resin oil were isobornyl acetate (37.9%), limonene (12.3%), bornyl acetate (7.4%), and myrtenol (5.8%), while the leaf oil contained β-selinene (18.1%), rimuene (14.2%), caryophyllene oxide (11.5%), spathulenol (10.5%), α-selinene (9.8%), and γ-muurolene (5.8%) as main constituents. The resin essential oil showed minimum inhibitory concentration (MIC) in the range of 250–500 μg/mL and minimum bactericidal concentration (MBC) in the range of 500 to >1000 μg/mL against pathogenic strains of eight bacteria.
TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization (2015)

TGF-β is necessary for HCC progression, acting by inducing Treg cell polarization.
Does Anglophone Chinese Diasporic Avant-Garde Writing Exist? (2012)

[Opening Paragraph]

This essay joins two active interests of mine: Anglophone writing by writers of Chinese descent in the diaspora and avant-garde literary writing. In my forthcoming book, Thinking Its Presence: Form, Race and Subjectivity in Contemporary Asian American Poetry (Stanford UP, 2013), I argue against the prevailing critical practice in the States of reading minority literature, including Asian American literature, for content—ethnic, ethnographic, sociological, autobiographical, and so on—with virtually no attention paid to the form, especially the literary aspects, of this body of literature. Indeed, judging from the criticism, one could almost say that “minority” and “the literary” are mutually exclusive categories for most literary critics, even those of the highest caliber. This mode of apprehending Asian American literary writing as extended Chinatown tour or as the rendered truths of a native informant is particularly problematic when one is reading minority experimental writing—writing, for example, that has no visible markers of ethnicity or a stable autobiographical “I” or other recognizable signs of ethnic writing.
Assessment of the impact of an early acute immune challenge on the diabetic retina (2022)

Abstract Purpose: Diabetic retinopathy (DR) is a leading cause of blindness worldwide. It has been claimed that infections may enhance the progression of retinal degenerative diseases to more severe stages. Infections prime microglia, the immune cells of central nervous system. Microglia‐mediated neuroinflammation is a hallmark of DR. We hypothesized that an infection at adolescence negatively impacts on the retina later in life when it is challenged with diabetes. Methods: An infection was mimicked by an intraperitoneal injection of lipopolysaccharide (LPS), in Wistar rats. Diabetes was induced by streptozotocin. Retinal function was assessed by electroretinography and retinal structure was evaluated by optical coherence tomography (OCT). Microglia reactivity was assessed by immunolabelling Iba‐1 and MHC‐II. Results: We evaluated first the impact of LPS per se on the retina. Scotopic threshold response, indicative of retinal ganglion cell function, presented a significant decreased amplitude 30 days after LPS injection, without alterations in the function of other retinal neurons. OCT revealed that 1 day after LPS there was an increase in the thickness of inner retinal layers. Eye fundus images showed a thickening of retinal vessels and the presence of vitreous infiltrates, 1 and 5 days after LPS injection. LPS also significantly increased microglial reactivity 1 day after the injection. Then, we evaluated the impact of LPS when the retina was also exposed to a diabetic insult (30 days). In diabetic animals previously exposed to LPS, there was a decrease in the amplitude of cone response, evaluated by flicker (first and second harmonic). Conclusions: LPS per se affects the retina in several parameters, mainly in the first days upon LPS challenge. Moreover, LPS priming negatively impacts on cone cell function upon diabetes. Supported by FCT, Portugal (PEst UIDB/04539/2020 and UIDP/04539/2020) and Centro 2020 Regional Operational Programme (CENTRO‐01‐0145‐FEDER‐000008: BrainHealth 2020).
The Age of Information of Short-Packet Communications: Joint or Distributed Encoding? (2021)

In this paper, we analyze the impact of different encoding schemes on the age of information (AoI) performance in a point-to-point system, where a source generates packets based on the status updates collected from multiple sensors and transmits the packets to a destination. In this system, we consider two encoding schemes, namely, the joint encoding scheme and the distributed encoding scheme. In the joint encoding scheme, the status updates from all the sensors are jointly encoded into a packet for transmission. In the distributed encoding scheme, the status update from each sensor is encoded individually and the sensors' packets are transmitted following the round robin policy. To ensure the freshness of packets, the zero-wait policy is adopted in both schemes, where a new packet is immediately generated once the source finishes the transmission of the current packet. We derive closed-form expressions for the average AoI achieved by these two encoding schemes and compare their performances. Simulation results show that the distributed encoding scheme is more appropriate for systems with a relatively large number of sensors, compared with the joint encoding scheme.
Stretched-Exponential Modeling of Anomalous T 1 ρ and T 2 Relaxation in the Intervertebral Disc In Vivo (2020)

ABSTRACT Purpose Intervertebral disc degeneration (IVDD), resulting in the depletion of hydrophilic glycosaminoglycans (GAGs) located in the nucleus pulposus (NP), can lead to debilitating neck and back pain. Magnetic Resonance Imaging (MRI) is a promising means of IVD assessment due to the sensitivity of MRI tissue relaxation properties to matrix composition. Furthermore, anomalous (i.e. non-monoexponential) relaxation models have shown higher sensitivity to specific matrix components compared to conventional monoexponential models. Here, we extend the use of the stretched exponential model, an anomalous relaxation model, to IVD relaxometry data. Theory and Methods T 1 ρ and T 2 relaxation data were measured in the cervical IVDs of healthy volunteers and IVDs adjacent to cervical fusion, and analyzed using both conventional and stretched-exponential (SE) models. Model differences were evaluated via goodness of fit in the healthy data. Normalized histograms of the resultant quantitative MRI (qMRI) maps were described using stable distributions, and data were compared across adjacent disc segments. Results In the healthy IVDs, we found lower mean squared error in the SE relaxation model fitting behavior compared to monoexponential models, supporting anomalous relaxation behavior in healthy IVDs. SE model parameter α T1 ρ increased level-wise in the caudal direction, especially in the nucleus pulposus, while conventional T 1 ρ and T 2 monoexponential measures did not vary. For IVDs adjacent to cervical fusion, SE parameters deviated near the fusion site compared with those in the healthy population. Conclusion SE modeling of T 1 ρ relaxation provides greater sensitivity to level-wise variation in IVD matrix properties compared with conventional relaxation modeling, and could provide improved sensitivity to early stages of IVD degeneration. The improved model fit and correlation between the SE α T1 ρ parameter with IVD level suggests SE modeling may be a more sensitive method for detection of GAG content variation.
A weighted combination of classifiers employing shared and distinct representations (2002)

This paper presents a theoretical framework for the combination of soft decisions generated by experts employing mixed (some shared and some distinct) object representations. By taking the confidence of the individuals experts into account, weighted benevolent fusion strategies are derived. This provides a basis for combining classifiers and illustrates that a substantial gain in performance can be achieved by using the opinions of multiple experts. These strategies are experimentally tested and their effectiveness is considered.
Matrix Metalloproteinase-3 Enhances the Free Fatty Acids-Induced VEGF Expression in Adipocytes Through Toll-Like Receptor 2 (2008)

Infiltrated macrophages (Mphi) are believed to cause pathological changes in the surrounding adipocytes through the secretion of active molecules in visceral fat. Matrix metalloproteinase (MMP)-3 is secreted from Mphi, and enhances expression of the inflammatory cytokines through the activation of toll-like receptor (TLR) 2. Visceral adipocytes express high levels of vascular endothelial growth factor (VEGF), and the degree of visceral fat accumulation is associated with the plasma VEGF concentration in obese subjects. The aim of the study is to clarify the role of MMP-3 in the enhancement of the free fatty acids (FFAs)-induced VEGF expression through TLR2 in visceral adipocytes. One mM FFAs induced VEGF mRNA and protein expression in 3T3-L1 adipocytes. The FFAs-induced VEGF expression was mostly mediated by TLR2. A high fat intake increased the VEGF mRNA expression in visceral fat and the VEGF concentration in plasma, accompanied with the increase in the plasma FFAs concentration in mice. These increases were largely inhibited in TLR2-deficient mice. The FFAs-induced VEGF expression was increased in the presence of Mphi-conditioned medium (CM) in adipocytes, and the enhancement was inhibited by a MMP-3 inhibitor or a neutralizing antibody against MMP-3. The active form of MMP-3 induced the VEGF mRNA expression, as well as TLR2, in adipocytes. The increase in the VEGF expression by MMP-3 was inhibited by the treatment with siRNA for TLR2. The enhancement of FFAs-induced TLR2 expression by Mphi-CM was inhibited by blocking of the MMP-3. The increase in the VEGF mRNA expression by Mphi-CM or MMP-3 was partially inhibited by a neutralizing antibody against TNF-alpha. These results indicate that MMP-3 in Mphi-CM enhances the FFAs-induced VEGF expression in adipocytes through the increase in the TLR2 expression. The MMP-3 secreted from the infiltrated Mphi may be a regulator of the VEGF expression in visceral adipocytes.
Short channel models and scaling limits of SOI and bulk MOSFETs (1994)

Analytical device-physics-based models for subthreshold drain current in short channel SOI MOSFETs facilitate accurate and efficient circuit simulation. These models also enable prediction of device scaling limits determined by subthreshold conduction and comparison of these limits with bulk MOSFETs for the same threshold and supply voltages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prognostic effect of preoperative systemic immune-inflammation index in patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma (2022)

We found an independent association of high SII prior to CN with unfavorable clinical outcomes, particularly in patients with intermediate risk mRCC and patients with increased BMI. Despite these results, it does not seem to add any prognostic or clinical benefit beyond that obtained by currently available clinicopathologic characteristics as sole worker.
Role of the advanced nurse practitioner within the vascular team: A qualitative study of vascular physicians and nurses (2023)

Advanced nurse practitioners could be the missing link in a "Vascular team" by creating a continuum in the care of patients with PAD, ensuring clinical assessment, nursing supervision, adverse event screening, and renewing drug prescriptions with the required adaptations while ensuring essential part of therapeutic education adapted to each patient.
Temperature Sensing with Up-Converting Submicron-Sized LiNbO3:Er3+/Yb3+Particles (2011)

We present the temperature dependence of the green up-converted luminescence in submicron-sized LiNbO3:Er3+/Yb3+ particles in the range between 12 and 180 °C. It is shown that LiNbO3:Er3+/Yb3+ exhibits a very high sensitivity (S = 0.007/°C at physiological temperature and a maximum value of S = 0.014/°C at 350 °C) that surpasses those previously found for other materials based on Er3+/Yb3+ luminescence, indicating that LiNbO3:Er3+/Yb3+ is a suitable probe for optical temperature sensing through the fluorescence intensity ratio technique. This high sensitivity can be explained using the intrinsic spectroscopic parameters of Er3+ ions in this host.
How to calculate tortuosity easily? (2012)

Tortuosity is one of the key parameters describing the geometry and transport properties of porous media. It is defined either as an average elongation of fluid paths or as a retardation factor that measures the resistance of a porous medium to the flow. However, in contrast to a retardation factor, an average fluid path elongation is difficult to compute numerically and, in general, is not measurable directly in experiments. We review some recent achievements in bridging the gap between the two formulations of tortuosity and discuss possible method of numerical and an experimental measurements of the tortuosity directly from the fluid velocity field.
Inhibition of Signal Ca2+ in Dog Coronary Arterial Vascular Muscle Cells by Ro 40–5967 (1994)

The effects of Ro 40-5967, a chemically novel Ca2+ channel antagonist, were examined on K(+)- and norepinephrine (NE)-stimulated intracellular free Ca2+ concentrations in dog coronary artery vascular muscle cells (VMC). Intracellular Ca2+ activity increases stimulated by NE or K+ were measured by shuttered, low-intensity illumination with the fluorescent Ca2+ indicator fluo3 in single myovascular cells < or = 2 days after isolation. Pretreatment of VMC for 5 min with 10 microM Ro 40-5967 significantly reduced intracellular Ca2+ activity increase on exposure to 100 mM K+ in both subsarcolemmal (SSL) and central regions during K+ depolarization, similar to actions of diltiazem. More impressively, Ro 40-5967 (but not diltiazem) also reduced intracellular Ca2+ activity during stimulation with 100 nM NE to basal level at both peripheral and central regions. Prevention of Ca2+ increases, especially those caused by release from central Ca2+ stores, during NE stimulation is an unusual property for a Ca2+ antagonist, as shown by the contrast with diltiazem, which did not significantly attenuate Ca2+ increases during NE stimulation. Another Ro 40-5967 feature was vascular selectivity; i.e., Ro 40-5967 had only a minor effect on contraction frequency of rat myocardial cells while significantly inhibiting spontaneous contractions of rat spontaneously active VMC. In comparison, diltiazem and verapamil potently inhibited both vascular and cardiac muscle spontaneous contractions. The decidedly stronger actions of Ro 40-5967 as compared with those of benzothiazepine or phenylalkylamine on NE-stimulated Ca2+ increases, together with less action on cardiac pacemakers, are differences that appear to distinguish Ro 40-5967 from other Ca2+ antagonists.
Multiscale time-domain time-lapse full-waveform inversion with a model-difference regularization (2017)

We present a multiscale time-lapse full-waveform inversion (4D FWI) technique based on a cascaded time-domain simultaneous inversion of multiple surveys with a model-difference regularization. In our cascaded approach, different model scales are recovered using different objective functions and regularization penalties. We apply our method to a synthetic example, and demonstrate a robust recovery of production-induced velocity changes in the presence of repeatability issues and errors in the amplitude information. Presentation Date: Wednesday, September 27, 2017 Start Time: 10:10 AM Location: 361F Presentation Type: ORAL
CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells (2016)

CCDC88A was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and increased the migration and invasiveness of PDAC cells.
Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship (2021)

Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the <i>N</i>1-ribosylated, Ca<sup>2+</sup>-mobilizing, second messenger cyclic adenosine 5'-diphosphoribose (cADPR). <i>N</i>1-Inosine 5'-monophosphate (<i>N</i>1-IMP) is a fragment directly related to cADPR. 8-Substituted-<i>N</i>1-IMP derivatives, prepared by degradation of cyclic parent compounds, inhibit CD38-mediated cADPR hydrolysis more efficiently than related cyclic analogues, making them attractive for inhibitor development. We report a total synthesis of the <i>N</i>1-IMP scaffold from adenine and a small initial compound series that facilitated early delineation of structure-activity parameters, with analogues evaluated for inhibition of CD38-mediated hydrolysis of cADPR. The 5'-phosphate group proved essential for useful activity, but substitution of this group by a sulfonamide bioisostere was not fruitful. 8-NH<sub>2</sub>-<i>N</i>1-IMP is the most potent inhibitor (IC<sub>50</sub> = 7.6 μM) and importantly HPLC studies showed this ligand to be cleaved at high CD38 concentrations, confirming its access to the CD38 catalytic machinery and demonstrating the potential of our fragment approach.
Regulation of a Transcription Factor Network Required for Differentiation and Metabolism (1998)

Hepatocyte nuclear factors (HNFs) are a heterogeneous class of evolutionarily conserved transcription factors that are required for cellular differentiation and metabolism. Mutations in HNF-1alphaand HNF-4alpha genes impair insulin secretion and cause type 2 diabetes. Regulation of HNF-4/HNF-1 expression by HNF-3alpha and HNF-3beta was studied in embryoid bodies in which one or both HNF-3alpha or HNF-3beta alleles were inactivated. HNF-3beta positively regulated the expression of HNF-4alpha/HNF-1alpha and their downstream targets, implicating a role in diabetes. HNF-3beta was also necessary for expression of HNF-3alpha. In contrast, HNF-3alpha acts as a negative regulator of HNF-4alpha/HNF-1alpha demonstrating that HNF-3alpha and HNF-3beta have antagonistic transcriptional regulatory functions in vivo. HNF-3alpha does not appear to act as a classic biochemical repressor but rather exerts its negative effect by competing for HNF-3 binding sites with the more efficient activator HNF-3beta. In addition, the HNF-3alpha/HNF-3beta ratio is modulated by the presence of insulin, providing evidence that the HNF network may have important roles in mediating the action of insulin.