gebhart/patrepeval huggingface dataset:
Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability (2010)

Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P(EMP) = 1.9 x 10(-4)). The association with heterotrimeric G proteins was validated in an independent population sample of 1507 subjects. Heterotrimeric G proteins are central relay factors between the activation of plasma membrane receptors by extracellular ligands and the cellular responses that these induce, and they can be considered a point of convergence, or a "signaling bottleneck." Although alterations in synaptic signaling processes may not be the exclusive explanation for the association of heterotrimeric G proteins with cognitive ability, such alterations may prominently affect the properties of neuronal networks in the brain in such a manner that impaired cognitive ability and lower intelligence are observed. The reported association of synaptic heterotrimeric G proteins with cognitive ability clearly points to a new direction in the study of the genetic basis of cognitive ability.
Zur Disproportionierung aliphatischer Aldehyde (1951)

Abstract Es wurde festgestellt, dass Isobutyraldehyd, 2‐Methyl‐n‐pentanal und 2‐Äthyl‐n‐hexanal quantitativ zu den entsprechenden Alkoholen und Säuren disproportionieren, wenn sie mit wässeriger Natronlauge auf 170–200° erhitzt werden.
Do Turbulent Premixed Flame Fronts in Spark-Ignition Engines Behave Like Passive Surfaces? (2000)

&lt;div class="htmlview paragraph"&gt;A widely held belief in the combustion community is that the chemical and hydrodynamic structure of a stretched laminar premixed flame can be preserved in a turbulent flow field over a range of conditions collectively known as the flamelet regime, and the homogeneous charge spark-ignition engine combustion falls within the domain of this regime. The major assumption in the laminar flamelet concept as applied to the turbulent premixed flames is that the flame front behaves as a constant-property passive scalar surface, and an increase in the wrinkled flame surface area with increasing turbulence intensity is the dominant mechanism for the observed flame velocity enhancement. The two approaches that have been recently used for estimating a measure of the wrinkled flame surface area in spark-ignition engines and other premixed flames are the flame surface density concept and fractal geometry. A critical assessment of the experimental fractal parameters reported in literature indicated that these are not capable of correctly predicting the turbulent burning velocity using the available fractal area closure model. A similar conclusion has been reached after examining the surface density data from flames of different geometries including spark-ignition engine flame fronts. The assumption made in fractal and surface density approaches that the turbulent flame front is a passive scalar surface can not be justified, and the applicability of the flamelet approach may be limited to a much smaller range of conditions than presently believed.&lt;/div&gt;
Retinal Pigment Epithelial Tears and the Management of Exudative Age-Related Macular Degeneration (2011)

Tears of the retinal pigment epithelium (RPE) are a known and potentially catastrophic complication of exudative age-related macular degeneration (AMD). Eyes with vascularized retinal pigment epithelial detachments (PED) are especially at risk for the development of RPE tears. This long-recognized complication faces increased scrutiny in an era of improved anti-angiogenic treatments for AMD, particularly given that these newly developed therapeutics have been implicated as a potential factor in the formation of some RPE tears.
Fuzzy logic regulated power supply for a UHF digital television transmission (2003)

In this work, we show that the fuzzy logic controller can be used to significantly improve the performance of a power supply regulator over conventional control techniques. The existing linear regulator circuit used in the current design has excessive overshoot and ringing in response to step changes, particularly during initial turn-on into a cold (very low impedance) filament. The linear regulator compensates for gradual changes in the load, but an external system must apply the reference voltage gradually to prevent excessive overshoot. For these reasons, a fuzzy controller is an excellent choice to provide the needed nonlinear regulation. This regulator is used in high power amplifiers produced by Thales Broadcast and Multimedia, a manufacturer of UHF television transmitters located in Southwick, Massachusetts.
Advancing our Understanding of Ubiquitination Using the Ub-Toolkit (2017)

Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated by the sequential action of Ub-activating, -conjugating, and -ligating enzymes to regulate a vast array of fundamental biological processes. Unsurprisingly, the dysregulation of the intricate interplay between ubiquitination and deubiquitination gives rise to numerous pathologies, most notably cancer and neurodegenerative diseases. While activity-based probes (ABPs) and assay reagents have been extensively developed and applied for deubiquitinating enzymes, similar tools for the Ub cascade have only recently emerged. Given the recent efforts to develop inhibitors for the Ub system, the urgency for developing ABPs and assay reagents is imminent. In this light, we comprehensively discuss the currently available ABPs with a focus on the newly developed reagents targeting the Ub cascade while illustrating their potential applications.
A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER Associated Degradation (2007)

How the ER‐associated degradation (ERAD) machinery accurately identifies terminally misfolded proteins is poorly understood. For luminal ERAD substrates, this recognition depends on their folding and glycosylation status as well as on the conserved ER lectin Yos9p. We find that Yos9p is part of a stable complex that organizes key components of ERAD machinery on both sides of the ER membrane including the transmembrane ubiquitin ligase Hrd1p. We further demonstrate that Yos9p, together with Kar2p and Hrd3p, forms a luminal surveillance complex that both recruits non‐native proteins to the core ERAD machinery and assists a distinct sugar‐dependent step necessary to commit substrates for degradation. When Hrd1p is uncoupled from the Yos9p surveillance complex, degradation can occur independent of the requirement for glycosylation. Thus Yos9p/Kar2p/Hrd3p acts as a gatekeeper, ensuring correct identification of terminally misfolded proteins by recruiting misfolded forms to the ERAD machinery, contributing to the interrogation of substrate sugar status, and preventing glycosylation‐independent degradation.
Carbon-13 Nuclear Magnetic Resonance: Naturally Occurring Nucleosides (1970)

The natural-abundance carbon-13 nuclear magnetic resonance spectra of the naturally occuring pyrimidine and purine nucleosides have been determined and completely analyzed. The carbon-13 chemical shifts obtained provide information on the electronic structure and qualitatively at least correlate well with the known chemical reactivity of these molecules. The carbon-13 shifts are in general far more informative than proton shifts for structural analysis of the nucleosides.
Correlations among tracheal dimensions, tracheal stent dimensions, and major complications after endoluminal stenting of tracheal collapse syndrome in dogs (2019)

A higher taper in tracheal diameter may lead to increased risk of fracture in the IT location. Dogs with tracheal malformations may have higher risk for thoracic inlet fracture and development of obstructive tissue ingrowth. Clinicians should be aware of the possible risk factors for tracheal stent complications.
High-strength, high-modulus AlB/sub 2/ flake reinforced composites. Technical report 1 Mar 1972--28 Feb 1973 (1973)

The development of high strength, high modulus AlB/sub 2/ flake reinforced composites with properties isotropic in the plane of the flakes was continued. Parameters affecting yields and dimensions of flakes were investigated. The use of non-aqueous solvent in flake elutriation was explored. Binary AlB composites were prepared and tested to broaden the information on their mechanical behavior. A wide range of ternary composites containing flakes between plies of graphite fibers were investigated. (auth)
Optimization of the MPS rectifier via variation of Schottky region area (2002)

The authors discuss the optimization of the switching characteristics of the MPS (merged PIN/Schottky) rectifier by varying the relative area of the P-N junction and Schottky regions. Extensive two-dimensional numerical simulations have been performed of the forward condition and reverse recovery switching characteristics. It has been found that a trade-off curve between the forward voltage drop and the reverse recovery time can be obtained by varying the area of the Schottky region, while maintaining a constant minority carrier lifetime. This trade-off curve is superior to that obtained for the PIN rectifier using lifetime control. Experimental data that corroborate this theoretical prediction have been obtained by fabrication of 700 V devices. This method of performing the trade-off between the forward drop and the turn-off time has the advantage that it can be done by device design without the problems and additional processing cost associated with lifetime control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A non-cooperative power control game for multi-carrier CDMA systems (2005)

In the power control game proposed for MC-CDMA systems, each user needs to decide how much power to transmit over each carrier to maximize its overall utility. The utility function considered measures the number of reliable bits transmitted per joule of energy consumed. It is shown that the user's utility is maximized when the user transmits only on the carrier with the best "effective channel". The existence and uniqueness of Nash equilibrium for the proposed game are investigated and the properties of equilibrium are studied. Also, an iterative and distributed algorithm for reaching equilibrium (if it exists) is presented. It is shown that the proposed approach results in a significant improvement in the total utility achieved at equilibrium compared to the case in which each user maximizes its utility over each carrier independently.
The impact of SARS-CoV-2 infection and vaccination on inflammatory arthritis: a cohort study (2023)

A significantly higher rate of IA flare was observed among patients who contracted SARS-CoV-2 infection vs. those without infection. Patients with IA experienced flares after SARS-CoV-2 vaccination, though it was not statistically significant.
Metallographic Analysis of Brush Bristle and Integrity Testing of Brush Seal in Shroud Ring of T-700 Engine (1995)

Post-test investigation of a T-700 engine brush seal found regions void of bristles ('yanked out'), regions of bent-over bristles near the inlet, some 'snapped' bristles near the fence, and a more uniform 'smeared' bristle interface between the first and last axial rows of bristles. Several bristles were cut from the brush seal, wax mounted, polished, and analyzed. Metallographic analysis of the bristles near the rub tip showed tungsten-rich phases uniformly distributed throughout the bristle with no apparent change within 1 to 2 micron of the interface except for possibly a small amount of titanium, which would represent a transfer from the rotor. Analysis of the bristle wear face showed nonuniform tungsten, which is indicative of material resolidification. The cut end contained oxides and internal fractures; the worn end was covered with oxide scale. Material losses due to wear and elastoplastic deformation within the shear zone and third-body lubrication effects in the contact zone are discussed.
Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19 (2020)

Five days of DRV/c did not increase the proportion of negative conversion vs standard of care alone, although it was well tolerated.
Nasogastric lansoprazole is effective in suppressing gastric acid secretion in critically ill patients (2000)

Nasogastric lansoprazole 30 mg daily is effective in suppressing gastric acid secretion in critically ill patients.
On the computer intensive methods in model selection (2008)

Bootstrap-based model selection has been shown in many practical instances to be superior to classical methods such the AIC and MDL. This is particularly noticeable when the distribution of modelling noise is unknown and/or when the available data samples are small. One of the main problems of using bootstrap model selection with real data is the necessity of tuning the residual scaling parameter or estimating the length of a sub-sample. Recently, we have developed a new hook and loop (HL) resampling plane, in which the scaling of the residuals is avoided. Here, we compare the performance of the range of resampling planes that can be used in the context of model selection and show that the HL-based model selection is superior to its predecessors. Moreover, in the context of fitting parametric models to corneal data measured by videokeratoscopes, the HL provides results that are consistent with clinical expectations.
Motor and mechanical bases of the courtship call of the male treehopper,Umbonia crassicornis (2017)

This study is a physiological, anatomical and biophysical analysis of how plant-borne vibrational signals are produced by the treehopper <i>Umbonia crassicornis</i> During courtship, males and females engage in a vibrational duet, with each producing a characteristic call. For males, this consists of a frequency-modulated tonal signal which is accompanied by rhythmic broad-band clicks. Although previous studies have described these complex signals in detail, little is known about how they are produced. By combining video recordings, electromyograms, dissections and mechanical modeling, we describe the mechanism by which the male produces his courtship signal. High-speed videos show that the tonal portion of the call is produced by periodic dorso-ventral movements of the abdomen, with a relatively large amplitude oscillation alternating with a smaller oscillation. Electromyograms from the muscles we identified that produce this motion reveal that they fire at half the frequency of the abdominal oscillation, throughout the frequency modulation of the tonal signal. Adding weight to the abdomen of a calling male reduces the frequency of motion, demonstrating that the abdominal motion is strongly influenced by its mechanical resonance. A mathematical model accounting for this resonance provides excellent qualitative agreement with measurements of both the muscle firing rate recorded electrophysiologically and the oscillatory motion of the abdomen as recorded in the high-speed video. The model, electromyograms and analysis of video recordings further suggest that the frequency modulation of the abdominal response is due to a simultaneous modulation in the muscle firing rate and a fluctuation in stiffness of the abdominal attachment.
[Effect of the continuous epidural saline infusion for patients with postdural puncture headache after pulmonary resection]. (2011)

The dual puncture is one of the diseaseful complications at the induction of the epidural anesthesia, which causes severe symptoms of intracranial hypotension such as headache and nausea. The clinical courses of 3 patients with the dual puncture symptoms after pulmonary resections were retrospectively reviewed, and the effect of the continuous epidural saline infusion treatment (CESI) for the dual puncture was evaluated. Pneumococcal empyema developed in 1 patient who had been treated with conservative management. In contrast, the symptoms of the others who were treated with the CESI were quickly recovered or were effectively prevented. This report strongly suggested that the CESI was convenient and effective treatment for dual punctune symptoms by suppressing the cerebrospinal fluid leakage by elevation of the fluid pressure in the extradural space.
A Simple and Robust Event-Detection Algorithm for Single-Cell Impedance Cytometry (2015)

Microfluidic impedance cytometry is emerging as a powerful label-free technique for the characterization of single biological cells. In order to increase the sensitivity and the specificity of the technique, suited digital signal processing methods are required to extract meaningful information from measured impedance data. In this study, a simple and robust event-detection algorithm for impedance cytometry is presented. Since a differential measuring scheme is generally adopted, the signal recorded when a cell passes through the sensing region of the device exhibits a typical odd-symmetric pattern. This feature is exploited twice by the proposed algorithm: first, a preliminary segmentation, based on the correlation of the data stream with the simplest odd-symmetric template, is performed; then, the quality of detected events is established by evaluating their E2O index, that is, a measure of the ratio between their even and odd parts. A thorough performance analysis is reported, showing the robustness of the algorithm with respect to parameter choice and noise level. In terms of sensitivity and positive predictive value, an overall performance of 94.9% and 98.5%, respectively, was achieved on two datasets relevant to microfluidic chips with very different characteristics, considering three noise levels. The present algorithm can foster the role of impedance cytometry in single-cell analysis, which is the new frontier in "Omics."
Poly(diarylsilmethylene)s, I. Synthesis and characterization (1995)

Abstract Poly(diarylsilmethylene)s with phenyl or tolyl substituents on Si atoms were synthesized by ring‐opening polymerization of corresponding 1,1,3,3‐tetraaryl‐1,3‐disilacyclobutanes, and were characterized by means of DSC, x‐ray diffraction and melt viscosity measurements. Three preparative routes including catalytic and noncatalytic polymerization methods were examined to see differences in properties of the resulting polymers. The polymers thus obtained were crystalline and soluble in limited solvents such as diphenyl sulfone at tem‐peratures above 250°C. Poly(diphenylsilmethylene) exhibited a melting temperature of about 350°C, whereas those of polymers with tolyl groups were observed in a temperature range between 310 and 330°C. The melt viscosity of the poly(diarylsilmethylene)s was measured to obtain insight into the molecular weights of the polymers, and the results indicated that the molecular weights are modifiable by varying the monomer‐to‐catalyst ratio when solution polymerization is employed. The DSC and x‐ray studies were also carried out with focusing on the melting and crystallization behavior of these polymers. © 1995 John Wiley &amp; Sons, Inc.
Secure charging and payment protocol (SCPP) for roaming plug-in electric vehicles (2017)

Users of plug-in-electric vehicles (PEV) often need to charge outside their home power grid networks i.e. outside their supplier. This basically constitutes a roaming charging case. Hence, users should be protected from possible security and privacy attacks. Moreover, remote authorization and payment transaction mechanism is required between the different power suppliers. In this paper, we propose a secure charging and payment transaction protocol for roaming PEV charging. Our protocol is developed based on the principles of the Secure Electronic Transaction (SET) protocol. The protocol protects user's privacy not only from external suppliers but also from their own suppliers. Moreover, our protocol is designed in such a way that it is robust against the known security attacks. Our proposed work provides anonymous authorization and payment simultaneously not only between the roaming user and an external supplier but also between suppliers.
Optimization of SOAT: Example of Naphthamide deracemization (2017)

International audience
Automatic Craniomaxillofacial Landmark Digitization via Segmentation-Guided Partially-Joint Regression Forest Model and Multiscale Statistical Features (2015)

Our automatic landmark digitization method can be used clinically to reduce the labor cost and also improve digitalization consistency.
Effect of increasing thickness on tensile-strained germanium grown on InGaAs buffer layers (2013)

We have investigated the optical properties of tensile-strained germanium grown on InGaAs buffer layers as a function of film thickness and buffer layer composition. We study the dependence of the photoluminescence as a function of the strain amplitude and degree of relaxation which are also monitored by X-ray diffraction and Raman spectroscopy. We show that 0.75% biaxially strained germanium can be obtained up to a thickness of 150 nm, a value sufficiently high to allow confinement of the spontaneous emission in a guiding structure. For large thicknesses (&amp;gt;200 nm) and large indium content in the buffer layer, a partial relaxation of the film is observed characterized by a large in-plane anisotropy of the germanium lattice. In this case, a difference of strain magnitude deduced either by microphotoluminescence spectra or by X-ray or Raman measurements is reported. We explain this difference by the sensitivity of microphotoluminescence to the local properties of the material. This study provides guidelines in order to achieve high optical quality and high biaxial tensile strain in Ge films with thicknesses compatible with optical waveguiding.
Facile Synthesis of Graphene Quantum Dots from 3D Graphene and their Application for Fe3+ Sensing (2014)

Owing to their small size, biocompatibility, unique and tunable photoluminescence, and physicochemical properties, graphene quantum dots (GQDs) are an emerging class of zero‐dimensional materials promising a wide spectrum of novel applications in bio‐imaging, optical, and electrochemical sensors, energy devices, and so forth. Their widespread use, however, is largely limited by the current lack of high yield synthesis methods of high‐quality GQDs. In this contribution, a facile method to electrochemically exfoliate GQDs from three‐dimensional graphene grown by chemical vapor deposition (CVD) is reported. Furthermore, the use of such GQDs for sensitive and specific detection of ferric ions is demonstrated.