gebhart/patrepeval huggingface dataset:
Prototype Filter Optimization to Minimize Stopband Energy With NPR Constraint for Filter Bank Multicarrier Modulation Systems (2012)

Recently, filter bank multicarrier (FBMC) modulations have attracted increasing attention. The filter banks of FBMC are derived from a prototype filter that determines the system performance, such as stopband attenuation, intersymbol interference (ISI) and interchannel interference (ICI). In this paper, we formulate a problem of direct optimization of the filter impulse-response coefficients for the FBMC systems to minimize the stopband energy and constrain the ISI/ICI. Unfortunately, this filter optimization problem is nonconvex and highly nonlinear. Nevertheless, observing that all the functions in the optimization problem are twice-differentiable, we propose using the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\alpha$</tex></formula> -based Branch and Bound ( <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\alpha$</tex> </formula> BB) algorithm to obtain the optimal solution. However, the convergence time of the algorithm is unacceptable because the number of unknowns (i.e., the filter coefficients) in the optimization problem is too large. The main contribution of this paper is that we propose a method to dramatically reduce the number of unknowns of the optimization problem through approximation of the constraints, so that the optimal solution of the approximated optimization problem can be obtained with acceptable computational complexity. Numerical results show that, the proposed approximation is reasonable, and the optimized filters obtained with the proposed method achieve significantly lower stopband energy than those with the frequency sampling and windowing based techniques.
The conformations of tropanes (1966)

A combination of proton-resonance-spectroscopic and dipole-moment measurements confirms that tropanes exist with the piperidine ring in a chair conformation and with the N-methyl substituent predominantly equatorial. A 3α-substituent causes considerable ring deformation.
Rewrite rules for search database systems (2011)

The results of a search engine can be improved by consulting auxiliary data. In a search database system, the association between the user query and the auxiliary data is driven by rewrite rules that augment the user query with a set of alternative queries. This paper develops a framework that formalizes the notion of a rewrite program, which is essentially a collection of hedge-rewriting rules. When applied to a search query, the rewrite program produces a set of alternative queries that constitutes a least fixpoint (lfp). The main focus of the paper is on the lfp-convergence of a rewrite program, where a rewrite program is lfp-convergent if the least fixpoint of every search query is finite. Determining whether a given rewrite program is lfp-convergent is undecidable; to accommodate that, the paper proposes a safety condition, and shows that safety guarantees lfp-convergence, and that safety can be decided in polynomial time. The effectiveness of the safety condition in capturing lfp-convergence is illustrated by an application to a rewrite program in an implemented system that is intended for widespread use.
Antigenic structure of rabies virus glycoprotein: ordering and immunological characterization of the large CNBr cleavage fragments (1982)

After rabies virus glycoprotein was treated with CNBr, the peptide mixture was fractionated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. CNBr-cleaved peptide fragments were resolved into seven peptide bands under reducing conditions and six peptide bands under nonreducing conditions. The isolated nonreduced polypeptides were further analyzed by electrophoresis under reducing conditions. The N-terminal amino acid sequences were determined for the peptides in each of the isolated bands. The sequence data identified eight CNBr peptides and allowed the peptide fragments to be ordered within the deduced amino acid sequence of the glycoprotein. Analysis of the nonreduced CNBr peptides revealed two conformations of the glycoprotein. Two CNBr peptide fragments were specifically immunoprecipitated with a hyperimmune anti-rabies glycoprotein serum. These two and one other CNBr peptide induced the production of rabies virus-neutralizing antibodies, indicating the existence of at least three distinct antigenic sites on the rabies virus glycoprotein.
Supersymmetry-assisted high-fidelity ground-state preparation of a single neutral atom in an optical tweezer (2021)

Arrays of neutral-atom qubits in optical tweezers are a promising platform for quantum computation. Despite experimental progress, a major roadblock for realizing neutral-atom quantum computation is the qubit initialization. Here we propose that supersymmetry, a theoretical framework developed in particle physics, can be used for ultrahigh-fidelity initialization of neutral-atom qubits. We show that a single atom can be deterministically prepared in the vibrational ground state of an optical tweezer by adiabatically extracting all excited atoms to a supersymmetric auxiliary tweezer. The scheme works for both bosonic and fermionic atom qubits trapped in realistic Gaussian optical tweezers and may pave the way for realizing large-scale quantum computation, simulation, and information processing with neutral atoms.
Detecting transverse material boundaries in multilayer anthropogenic structures (2016)

The Kirchhoff approximation has been used to analytically determine the field that is generated by the reflection of an acoustic wave from an interface with a sharp acoustic impedance gradient. Visual formulas have been derived to describe the incoming signal when the boundary is exposed to a pulsed point source. On the basis of numerical modeling and an experimental study of multilayer systems, the suggested approach is applicable for detecting flaws in planar and cylindrical structures under pulse excitation. An algorithm is given for improving the accuracy of locating the rupture boundary. It is based on revealing correlations in wave field parameters at various points in the system.
Tumor necrosis factor soluble receptor p55 and lipid peroxidation in patients with acute alcoholic hepatitis (2001)

Our data support the notions that, in patients with AAH, TNFsRp55 probably mediates cytotoxicity of TNF-alpha, and that cytotoxic effect could be amplified by tGSH depletion in enhancing lipid peroxidation.
Supplementary Data from SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity (2023)

Supplementary Data from SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
Glossopharyngeal and Limited Vagal Neurectomy for Cancer-Related Carotid Sinus Syncope (2009)

Head and neck cancer patients with cervical disease involving the glossopharyngeal or vagus nerves can experience dangerous cardiovascular phenomena, including carotid sinus syncope (CSS). Medical and minimally invasive interventions, including pacemaker placement, incompletely address the etiologies of syncopal episodes and therefore often provide limited benefit. The objectives of this report are to highlight the difficulties of managing cancer-related CSS, to present a highly effective surgical intervention, and to review the literature regarding the pathophysiology and treatment options for patients with cancer-related CSS. Two patients with cancer-related CSS continued to experience syncopal episodes despite medical and pacemaker therapy. Consequently, these patients underwent a suboccipital craniotomy for glossopharyngeal and limited vagal neurectomy. After surgery, both patients had uncomplicated postoperative courses with resolution of syncope.
MICRO-FOUR-POINT PROBES IN A UHV SCANNING ELECTRON MICROSCOPE FOR IN-SITU SURFACE-CONDUCTIVITY MEASUREMENTS (2000)

For in-situ measurements of surface conductivity in ultrahigh vacuum (UHV), we have installed micro-four-point probes (probe spacings down to 4 μm) in a UHV scanning electron microscope (SEM) combined with scanning reflection–high-energy electron diffraction (RHEED). With the aid of piezoactuators for precise positioning of the probes, local conductivity of selected surface domains of well-defined superstructures could be measured during SEM and RHEED observations. It was found that the surface sensitivity of the conductivity measurements was enhanced by reducing the probe spacing, enabling the unambiguous detection of surface-state conductivity and the influence of surface defects on the electrical conduction.
Expression of a Human Complementary DNA for the Multidrug Resistance Gene in Murine Hematopoietic Precursor Cells With the Use of Retroviral Gene Transfer (1990)

In multidrug resistance, cells become simultaneously resistant to anthracyclines, vinca alkaloids, epipodophyllotoxins, and certain other natural product cytotoxic drugs. Resistance results from synthesis of a multidrug transporter (P-glycoprotein) encoded by the MDR1 gene (also known as the PGY1 gene). In the present study, a retrovirus vector containing a complementary DNA for the human multidrug resistance gene HaMDR1/A was used to transfer the multidrug resistance phenotype to bone marrow cells of the DBA/2J mouse. A high proportion of transduced bone marrow cells showed resistance to both colchicine and vinblastine, as determined by in vitro colony formation of hematopoietic precursor cells. In addition, brief culturing of the cells in a cytotoxic drug following exposure to the retrovirus vector could be used to increase the proportion of bone marrow cell colonies that were resistant. These results may serve as a model for the generation and selection of bone marrow cells resistant to the toxic effects of chemotherapeutic agents in vivo.
Electrical characteristics and thermally induced metastability in an amorphous-silicon ambipolar transistor (1989)

Electrical characteristics and thermally induced metastability in a boron-doped hydrogenated amorphous silicon (a-Si:H) thin-film transistor (TFT) deposited at 180 degrees C are discussed. The on/off ratio of the conductance and the field-effect mobility are similar to those for undoped a-Si:H TFTs. The device characteristics exhibit n- and p-channel operations. The enhancement in the drain currents caused by double injections of electrons and holes appears for the p-channel operation of the TFT. Thermal quenching experiments on boron-doped a-Si:H silicon-nitride ambipolar TFTs give clear evidence of the coexistence of two distinct metastable changes: the metastable creation of the active dopants and dangling bonds appear to increase with quenching temperature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. (1994)

We have analyzed K-ras mutations and p53 alterations in 39 tumor and nontumor samples taken from nine patients with longstanding ulcerative colitis and colorectal carcinoma. Two of nine invasive carcinomas contained a K-ras mutation. By a combination of immunohistochemistry and single-strand conformation polymorphism analysis, p53 alterations were found in three of nine carcinomas. Five of 13 dysplastic lesions harbored a mutated K-ras gene, even in the absence of detectable changes in associated invasive tumors. One single focus of dysplastic mucosa harbored concomitant K-ras and p53 gene alterations. In two patients, a K-ras mutation was detected in epithelial lesions considered to be devoid of malignant potential (villous regeneration, active colitis). Our results indicate that: 1) the prevalence of K-ras and p53 genetic alterations found in ulcerative colitis-associated colonic carcinomas appears to be lower than in sporadic carcinomas; 2) K-ras mutations can be detected in dysplasia, villous regeneration, and active colitis and affect a subpopulation of the cells composing the lesions; 3) diverse genetic alterations can be detected in the same patient and the dysplastic lesions can exhibit a different genotype than the carcinomas; and 4) at least part of active colitis and villous regeneration lesions should be considered as preneoplastic in ulcerative colitis.
Compact, 3D-Printed Electron Impact Ion Source with Microfabricated, Nanosharp Si Field Emitter Array Cathode (2019)

Abstract We report the design, fabrication, and characterization of a novel miniature electron impact gas ionizer manufactured via silicon micromachining and high-resolution 3D printing. The ionizer uses an array of 2,500 gated silicon nano-sharp field emitters (20 μm emitter pitch) as cathode and a set of additively manufactured, finely featured polymer and metallic parts as three-dimensional ion-generating structure. Finite element simulation of a gated field emitter tip predicts a start-up bias voltage equal to 64 V –close to the 62 V turn-on bias voltage estimated via experiments. The Si field emitter array emits 124.5 μA of electron current with ~60% gate transmission while operating at 200 V. The ionization efficiency of the gas ionizer is linear with pressure, reaching values as high as ~0.4% at 5×10 −4 Torr.
Allogeneic Tendon-Derived Stem Cells Promote Tendon Healing and Suppress Immunoreactions in Hosts: In Vivo Model (2014)

The medium- to long-term healing effect and infiltration of inflammatory cells, after transplantation of allogeneic tendon-derived stem cell (TDSC) to the rat patellar tendon window wound, were examined. Allogeneic patellar TDSCs derived from a green fluorescent protein rat were used. The outcome of tendon healing and the infiltration of inflammatory cells were examined by histology and immunohistochemistry up to week 16 postinjury. The fate of the transplanted cells was examined by ex vivo fluorescent imaging and immunohistochemistry. Our results showed that the transplantation of allogeneic TDSCs promoted tendon healing with no increased risk of ectopic chondro-ossification up to week 16. A low infiltration of T cells, ED1 macrophages, ED2 macrophages, and mast cells in the window wound was obtained. The transplanted TDSCs were found in the window wound at week 1 and 2, but were absent after week 4 postinjury. In conclusion, allogeneic TDSCs promoted tendon repair in the medium to long term and exhibited weak immunoreactions and anti-inflammatory effects in the hosts after transplantation in a rat model. There was no increased risk of ectopic chondro-ossification after TDSC transplantation. The decrease in the number of transplanted cells with time suggested that allogeneic TDSCs did not promote tendon repair through direct differentiation.
Modeling live and dead lines in cache memory systems (1993)

An analytical model that predicts the fraction of live and dead lines present in a cache memory in a multitasking environment is presented. The model is two-fold. The first portion evaluates the number of live lines created in a fully associative cache during the execution of a process. The second portion models the interaction of two processes that share a cache and run in an interleaved fashion. The model admits direct-mapped, set-associative, and fully associative cache architectures. The complete model assumes a hyperbolic (or fractal) model of program behavior. It predicts the variations of the total number of lines (footprint) as well as the number of live lines held by a process in the various caches as a function of the number of cache accesses. The accuracy of the model is validated through trace driven simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A New Method for the Preparation of Peroxymonophosphoric Acid. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Reactions of the radical anions and dianions of aromatic hydrocarbons (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of the radical anions and dianions of aromatic hydrocarbonsN. L. HolyCite this: Chem. Rev. 1974, 74, 2, 243–277Publication Date (Print):April 1, 1974Publication History Published online1 May 2002Published inissue 1 April 1974https://pubs.acs.org/doi/10.1021/cr60288a005https://doi.org/10.1021/cr60288a005research-articleACS PublicationsRequest reuse permissionsArticle Views2582Altmetric-Citations259LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CTAB-free selective precipitation of gold nanoprisms in the presence of gold nanospheres (2018)

Trabajo presentado al E-MRS 2018 Fall Meeting, celebrado en Varsovia (Polonia) del 17 al 20 de septiembre de 2018.
Key Takeaways (2017)

Privileges as an attack vector represent the lowest-hanging fruit for threat actors in today’s next-generation digital economy.
Receptor Antibodies as Novel Therapeutics for Diabetes (2011)

Antibodies to receptors can block or mimic hormone action. Taking advantage of receptor isoforms, co-receptors, and other receptor modulating proteins, antibodies and other designer ligands can enhance tissue specificity and provide new approaches to the therapy of diabetes and other diseases.
Effect of glucarpidase on methotrexate levels and renal function: about five cases. (2017)

International audience
Eating disorders and sexual abuse: Lack of confirmation for a clinical hypothesis (1986)

Undocumented clinical reports have suggested that, among women in psychotherapy, women who have been sexually abused manifest an increased prevalence of eating disorders. The relationship between these two phenomena was investigated in a sample of women (N = 87) who were receiving group psychotherapy. Individual interviews were used to document the presence of a sexual abuse history. Diagnoses of anorexia nervosa and bulimia were based on DSM-III criteria. Rates of abnormal eating patterns in the absence of a fully diagnosable syndrome were also assessed. The following rates of eating disturbance were found in the total sample: 21% bulimic, 1% anorexic, and 82% with at least moderately abnormal eating patterns. Comparisons of women with and without histories of sexual abuse suggested no association between the occurrence of eating disturbance and a history of sexual abuse. The frequent cooccurrence of these two phenomena in female therapy clients may be sufficiently explained by their high base rates in this population but may have led clinicians to perceive a relationship where none exists.
Beijing Declaration of International Association of Neurorestoratology (2023 Xi'an version) (2023)

Peer reviewed
Nanosensors-Assisted Quantitative Analysis of Biochemical Processes in Droplets (2020)

<b>:</b> Here, we present a miniaturized lab-on-a-chip detecting system for an all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires-based field-effect transistors (FETs). We specifically focus on the analysis of β-galactosidase <i>e.g.</i>activity, which is an important enzyme of the glycolysis metabolic pathway. Furthermore, the efficiency of the synthesis and action of β-galactosidase can be one of the markers for several diseases, <i>e.g</i>., cancer, hyper/hypoglycemia, cell senescence, or other disruptions in cell functioning. We measure the reaction and reaction kinetics-associated shift of the source-to-drain current <i>I</i><sub>sd</sub> in the system, which is caused by the change of the ionic strength of the microenvironment. With these results, we demonstrate that the ion-sensitive FETs are able to sense the interior of the aqueous reactors; thus, the conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route toward a sensitive, optics-less analysis of biochemical processes.
Omics of oil biodegradation (2022)

Omics studies (metagenomics, transcriptomics, metabolomics, proteomics) for marine oil biodegradation research increased rapidly after the 2010 Deepwater Horizon (DWH) accident in the Gulf of Mexico. Since then, it has been demonstrated how omics techniques can be used to model and better understand pre-spill environments, monitoring during a spill and post-spill. Data that encompass everything from the ecosystem to the molecular level are needed for understanding the complicated process of petroleum biodegradation in marine environments. Consequently, using omics for monitoring oil in the ocean will help in developing more robust systems models and would make responses to spills much more defensible in terms of risks to the environment and people. Omics is enabling for a Systems Biology approach to oil spills which allows a search for hidden interactions and attributes at different trophic levels because ‘the whole is greater than the sum of its parts’.
Comparison of Temperatures Measured in Natural Gas and Gasoline Fuelled Engines (1990)

&lt;div class="htmlview paragraph"&gt;There has been concern that the use of natural gas in engines designed for gasoline fuelling can give rise to excessive temperatures. This is based on experience of exhaust valve recession, high piston temperatures and hot exhaust systems with conversions in New Zealand.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In order to establish some data this work has measured exhaust gas temperatures, piston, exhaust valve and cylinder head temperatures in a single cylinder research engine.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The data show that at wide open throttle and with the engine tuned to similar operating conditions (ie. the same fuel-air ratio and MBT spark timing), the natural gas fuelled engine generally has lower surface temperatures within the combustion chamber and lower exhaust gas temperatures than the gasoline fuelled engine. When the engine is operated at the same load on the two fuels the combustion chamber temperatures were similar for the two fuels.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The measurements also show that temperatures are very sensitve to fuel-air ratio and spark timing which leads to the conclusion that on-road experience of high temperatures with natural gas fuelling are probably the result of these factors, not of the fuel itself.&lt;/div&gt;
A Propulsion Concept for Circulation Control Wing Technology (2005)

&lt;div class="htmlview paragraph"&gt;Circulation control wing (CCW) technology has been in the research and development phase for over sixty years with a minimal amount of practical applications to subsonic transport aircraft. The concept is based on the use of high pressure Coanda jet air that is diverted from the fan or compressor of the main turbofan engines; however, this can create a significant decrease in engine performance. This paper will provide the background of past CCW research and conclude with recommendations for a conceptual design for a circulation control wing that implements multiple, lightweight gas generators, which are separate from the main aircraft engines that provide high pressure air or exhaust gas to the wing leading and trailing.&lt;/div&gt;