gebhart/patrepeval huggingface dataset:
A Randomised, Double-Blinded, Placebo-Controlled Study of the Phosphodiesterase Type 5 Inhibitor Sildenafil for the Treatment of Preeclampsia (2009)

We have safely conducted a clinical trial of a drug not routinely used during pregnancy. Sildenafil in the escalating dose regimen 20-80 mg tid was well tolerated, with no increase in maternal or fetal morbidity or mortality but did not prolong pregnancy duration in women with preeclampsia. (ClinicalTrials.gov number, NCT 00141310).
ChemInform Abstract: A New Bicyclic System with a P(V)‐P(III)‐P(V) Unit. (1988)

Abstract The bicyclic systems (III) and (V) containing a P(V)‐P(III)‐P(V) unit are prepared by the 2:3 molar reactions according to the scheme.
Development of B-field and E-field sensors based on coupled devices with nonlinear hysteretic behaviors (2005)

In this work we discuss the implementation of sensing devices based on ring-coupled hysteretic systems. In particular, the emergent oscillations in a ring coupled system formed by overdamped nonlinear devices having an hysteretic magnetic and electric behaviour are considered with applications to B-field and E-field measurements, respectively. Details on the implementation strategy, on the materials adopted and on the technologies will be given. The concept introduced is then extended to the area of E-field sensors taking into account nonlinear ferroelectric devices where oscillations can be obtained through a suitable connection topology in a similar way as for the magnetic field systems. The evaluation of the output signal dependence on the target electric field to be measured will be discussed and some device implementation issues will be reported. The proposed system combines benefits coming from reconsidering dated physical electro-static phenomena, with miniaturization levels provided by micro-technologies, to realize important electric field amplification. Devices based on different technologies, ranging from PCB to hybrid integrated microsystems, will be presented and discussed. Preliminary experimental results on E field sensor will be presented; the studies on B-field sensor are more mature and more comprehensive experimental results will be discussed to validate the working principle and to qualify the sensors in terms of sensitivity and noise floor.
Solid-state vibrational spectroscopy. Part V. An infrared and Raman spectroscopic study of metal(II) halide pyridine complexes (1976)

Infrared (200–4 000 cm–1) and Raman (300–3 500 cm–1) spectra are reported for metal(II) halide pyridine complexes of the following stoicheiometries: [MX2(py)2](M = Mn, Fe, Co, Ni, Cu, Zn, Cd, or Hg); [MX2(py)4](M = Fe, Co, or Ni); [MX2(py)2](M = Co, Cu, Cd, or Hg); and [Hg3X6(py)2](X = Cl or Br). Structure–spectra correlations have been found for the dipyridine complexes whose structures are either monomeric tetrahedral {M = Zn or Co; X = Cl or Br; [HgBr2(py)2] and [Cdl2(py)2]}, polymeric octahedral (M = Mn, Ni, or Cd; X = Cl or Br; M = Fe or Co; X = Cl), or distorted polymeric octahedral {M = Cu, X = Cl or Br; and [HgCl2(py)2]}. For a given series of isomorphous complexes there is a correlation between the sum of the difference between the liquid and ligand values of ν2, ν3, ν4, ν5, ν6, ν7, ν8, ν9, ν10, ν17, ν27, and (ν9+ν10) and the strength of the metal–nitrogen bond as measuredbythe ν(M–N) value.
PAUL: protein structural alignment using integer linear programming and Lagrangian relaxation (2009)

Computational Biology and Applied Algorithmics Group,Max-Planck-Institut fur Informatik, 66123 Saarbrucken, GermanyE-mail: Inken Wohlers* - I.Wohlers@cwi.nl*Corresponding authorfrom Fifth International Society for Computational Biology (ISCB) Student Council SymposiumStockholm, Sweden 27 June 2009Published: 19 October 2009BMC Bioinformatics 2009, 10(Suppl 13):P2 doi: 10.1186/1471-2105-10-S13-P2This article is available from: http://www.biomedcentral.com/1471-2105/10/S13/P2© 2009 Wohlers et al; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transmission Characteristics of the SOFAR Channel (1970)

The transmission of long single-frequency pulses of sound in the deep sound channel is described. Pulses of 2-sec duration and 778-Hz carrier frequency were transmitted for ranges up to 270 km in the area south of Bermuda. The measurements include the attenuation coefficient, transition range, and horizontal small-scale spatial variation. The transmission measurements were made to evaluate the feasibility of a freely drifting Swallow float able to signal for extended periods to land-based receiving stations.
Utility of specific bioelectrical impedance vector analysis for the assessment of body composition in children (2020)

The prediction of body composition can be improved by combining two different theoretical models, each of which appears to provide different information about the two components FFM and FM. Further work should test the utility of this approach in pediatric patients.
Compensation of skull motion and breathing motion in CT using data-based and image-based metrics, respectively (2016)

We present a novel reconstruction for motion correction of non-cardiac organs. With non-cooperative patients or in emergency case, breathing motion or motion of the skull may compromise image quality. Our algorithm is based on the optimization of either motion artefact metrics or data-driven metrics. This approach was successfully applied in cardiac CTA [1]. While motion correction of the coronary vessels requires a local motion model, global motion models are sufficient for organs like the lung or the skull. The parameter vector for the global affine motion is estimated iteratively, using the open source optimization library NLOPT. The image is updated using motion compensated reconstruction in each of the iterations. Evaluation of the metric value, e.g. the image entropy, provides information for the next iteration loop. After reaching the fixed point of the iteration, the final motion parameters are used for a motion-compensated full quality reconstruction. In head imaging the motion model is based on translation and rotation, in thoracic imaging the rotation is replaced by non-isotropic scaling in all three dimensions. We demonstrate the efficiency of the method in thoracic imaging by evaluating PET-CT data from free-breathing patients. In neuro imaging, data from stroke patients showing skull tremor were analyzed. It was shown that motion artefacts can be largely reduced and spatial resolution was restored. In head imaging, similar results can be obtained using motion artefact metrics or data-driven metrics. In case of image-based metrics, the entropy of the image proved to be superior. Breathing motion could also be significantly reduced using entropy metric. However, in this case data driven metrics cannot be applied because the line integrals associated to the ROI of the lung have to be computed using the local ROI mechanism [2] It was shown that the lung signal is corrupted by signals originating from the complement of the lung. Thus a meaningful optimization of a data-driven cost function is not possible.
Seasonal changes in hydrochemistry along a toposequence of texture-contrast soils (2002)

Ameliorative strategies are urgently required in some agricultural catchments in southern Australia to reduce the loss of potential contaminants to streams. However, a better understanding of where the contaminants are generated on hillslopes, their forms, and the pathways through which they are transported were required. Thus, seasonal changes in the quantities and forms of several chemical species were measured in both vertical and lateral flow pathways at 4 sites along a toposequence in the Mt Lofty Ranges, South Australia. Instrumentation was installed to measure and quantify overland flow and throughflow, and porous-wick samplers were installed at 2 depths to study the chemistry of leachate. Neutron moisture meter access tubes were installed to measure seasonal changes in soil water content with depth as this influences chemical concentrations and mobility. In years of average to below average annual rainfall, throughflow was the most important transport pathway for contaminants. However, it was expected that overland flow will be the dominant transport pathway when annual rainfall is above about 550 mm. Changes in water content of the texture-contrast soils was caused by seasonal rainfall causing periodic saturation, by waterlogging, groundwater, or both. This affected the type and form of contaminant. For example, Na and Cl concentrations were generally only large (800 and 1500 mg/L, respectively) on the lower slopes but in the wettest seasons their concentrations increased at depth on mid-slopes due to the influence of shallow saline groundwater. These chemicals then leached when groundwater levels subsided. The results suggest that ameliorative strategies to reduce agricultural contaminants should target the transport pathways specific to each chemical species, at the point (or points) in the landscape where they are generated.
Three-dimensional siloxane resist for the formation of nanopatterns with minimum linewidth fluctuations (1998)

Linewidth fluctuation of resist patterns is a serious problem in fabricating nanodevices when lithographic resolution is improved to the nanometer scale. As a resist material for reducing linewidth fluctuations, we evaluate hydrogen silsesquioxane (HSQ) with a three-dimensional framework from the standpoints of resist patterning and its ability to reduce linewidth fluctuation. Infrared analyses indicate that SiH bonds in HSQ are broken by electron-beam irradiation, and consequently, the crosslinking required for negative tone patterning is generated. By applying a TMAH developer suitable for the dissolution of the siloxane bonds in HSQ, we improve contrast and reduce the thickness loss of the lightly exposed resist area. In addition, the HSQ resist has relatively high sensitivity for resist materials without any reactive groups. The etching durability sacrificed for the attainment of high sensitivity is improved by oxygen plasma treatment. No damage, such as pattern-shape deformation after the oxygen plasma treatment, is observed. Linewidth fluctuation due to edge roughness of resist patterns results from aggregates in the resist polymer. Aggregates in HSQ are small owing to its three-dimensional framework. In addition, the excellent development property of HSQ avoids any influence from polymer aggregates on development. Consequently, linewidth fluctuation can be reduced to less than 2 nm. This leads to a decrease in the variation of gate capacitance in single-electron transistors.
Klimapolitischer Beitrag kohlenstoffarmer Energieträger in der dezentralen Stromerzeugung sowie ihre Integration als Beitrag zur Stabilisierung der elektrischen Versorgungssysteme : Endbericht (2015)

Das Ziel dieser Untersuchung war, das technische Regelleistungspotenzial von BHKW in Deutschland fur die Jahre 2010, 2020 und 2030 zu bestimmen. Der Fokus lag auf den kleineren Leistungsbereichen fur die objektscharfe Versorgung von Wohngebauden sowie von gewerblichen Objekten (Nichtwohngebauden). Erganzend wurde exemplarisch eine grosere BHKW-Anlage mit Warmenetz und ein industrieller Anwendungsfall untersucht.
The wound-healing matrix (1992)

A proposal for an assessment tool to ensure that relevant information is gathered before a decision on treatment is made.
European Cooperation on Dual Mode Route Guidance - Perspectives for Advanced Research Partners (1991)

&lt;div class="htmlview paragraph"&gt;Dual Mode Route Guidance (DMRG) is a concept which aims to combine “individual” route guidance (i.e. using on-board route calculation) and “collective” route guidance (i.e. using infrastructure-based route calculation) into one single system.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Because these two kinds of systems are based on competing philosophies addressing different social issues (individual control vs collective control), tremendous work has to be carried out before integration. The european automotive industry, in cooperation with E&amp;amp;S, has decided to concentrate efforts - within the frame of the PROMETHEUS programme and the DRIVE initiative - in order to turn the DMRG concept into a product before the end of the century.&lt;/div&gt;
Phase (Ph) 1/2a study of CLN-081 in patients (pts) with NSCLC with EGFR exon 20 insertion mutations (Ins20). (2022)

9007 Background: EGFR ins20-mutant NSCLC has historically been challenging to treat. While new agents targeting EGFR ins20 have recently been approved, adverse events (AEs), particularly wild type (WT) EGFR-related AEs are common. CLN-081 is a novel EGFR tyrosine kinase inhibitor (TKI) with broad activity against EGFR mutations, including ins20, and increased selectivity for ins20 versus WT EGFR. CLN-081 has been granted FDA Breakthrough Therapy Designation for the treatment of pts with EGFR ins20 NSCLC. We present updated results of the initial multicenter Ph1/2a study of CLN-081 in pts with advanced, EGFR ins20-mutant NSCLC, including 39 pts treated in an expanded cohort at the dose of 100 mg twice daily (BID). Methods: Ph1 dose escalation utilized an accelerated titration (AT) and rolling six design. Individual cohorts were expanded in Phase 1 and 2a based on prespecified protocol criteria. Pts were required to have received prior platinum-based chemotherapy. Stable, treated brain metastasis (mets) were allowed. CLN-081 is dosed in 21-day cycles. Results: As of 13 December 2021, 73 pts [median age: 65 (36-82), median lines of prior therapy: 2 (1-9), 28 (39%) with a history of brain mets] received CLN-081 at 30 mg (8), 45 mg (1), 65 mg (14), 100 mg (39), and 150 mg (11), all BID. Treatment-related AEs in ≥ 15% of pts were rash (74%), diarrhea (27%), paronychia (25%), fatigue (19%), anemia (18%), dry skin (18%), nausea (16%). Treatment-related Gr ≥ 3 AEs in ≥ 4 % of pts included anemia (10%), increased ALT (4%), and increased AST (4%). Gr 3 rash and Gr 3 diarrhea were observed in 1 and 2 pts, respectively, at 150 mg BID, while no pts treated at ≤ 100 mg BID experienced Gr 3 rash or diarrhea. Treatment-related dose reductions and discontinuations across all dose levels occurred in 10 pts (14%) and 5 pts (7%) respectively. Among 70 response-evaluable pts across all dose levels, 25 (36%) had a confirmed partial response (PR), 34 (49%) had stable disease (SD), and 3 (4%) had progressive disease as a best response. Seven pts (10%) had a PR that remained unconfirmed; 1 (1%) pt was pending a confirmatory scan. Of 36 response-evaluable pts at 100 mg BID, 14 (39%) had a confirmed PR, 17 (47%) had SD, and 1 (3%) had PD. Three pts had a PR that remained unconfirmed (8%); 1 (3%) pt was pending a confirmatory scan. Notably, among Ph1 pts treated at 100 mg BID (N = 13) in whom longer follow-up is available, the mDOR and mPFS (estimated by Kaplan-Meier) was &gt; 15 months and 12 months, respectively. Disease control (SD ≥ 6 months or any PR) was observed in 12/13 pts (92%). Updated data with additional follow-up will be presented. Conclusions: In pts with heavily-pretreated advanced EGFR ins20 NSCLC, CLN-081 has a manageable safety profile, with anti-tumor activity across the range of doses tested. Further, CLN-081 has demonstrated a favorable clinical profile at the dose of 100 mg BID, with an encouraging objective response rate, response durability, and no Gr 3 rash or diarrhea. Clinical trial information: NCT04036682.
Methotrexate serum binding in rheumatoid arthritis. (1994)

The serum binding of methotrexate was determined by equilibrium dialysis using radiolabelled methotrexate. Methotrexate was only albumin-bound in serum. The binding was 46% in controls versus 42% in rheumatoid arthritis and 44% in cancer. Serum binding was significantly decreased by salicylate and high concentration of naproxen. Hypoalbuminemia and concomitant administration of salicylate or naproxen may influence methotrexate toxicity.
A Torque-Free Flexible Model Gyro (1992)

The present investigation is concerned with the behavior of an elastic, oblate, torquefree gyro model. The model has been devised such that it represents accurately arbitrarily large attitudes and arbitrarily large deformations. All simplifying assumptions are incorporated into the model before the theory is applied. The subsequent theoretical development is consequently exact; i.e., the expressions for inertia moments, angular moments, kinetic and elastic energies are all exact. Also, the mass center of the model gyro does not shift within the gyro. Equations remain tractable and the practicing engineer can readily get a feel for the phenomena uncovered. The model is composed of a rigid massless rod connected elastically to a rigid massive disk. At the tip of each rod there is a point mass. The nonlinear equations of quasistatic motion are derived using Euler’s law, and a floating coordinate frame. Following the analysis, various numerical examples are investigated and the results are plotted. The total mechanical energy of the system is determined, and the condition for existence of an energy trap state (minimum energy state at an attitude other than zero) is obtained. When trapped, the gyro is in effect rigid, has a stable attitude, and rotates around the principal axis of maximum inertia, which in turn is collinear with the space-fixed angular momentum vector.
Outcomes of endoscopic ultrasound and endoscopic resection of gastrointestinal subepithelial lesions: a single-center retrospective cohort study (2021)

EUS plays an important role in the outcome of resection approach for SELs, with size significantly influencing the selection for ER. In patients undergoing ER, no revised resections were needed when EUS was inaccurate.
The passage from Rio. (1993)

The Secretary-General of the UN Conference on Environment and Development notes that after the Earth Summit in Rio de Janeiro discussions about the environment and development will differ from those prior to the Summit. These discussions must now incorporate problems of developing countries, poverty, inequalities, flow of resources to developing countries, and terms of trade. The Rio Declaration on Environment and Development consists of important tenets, but it must evolve into an Earth Charter to be endorsed on the 50th anniversary of the UN in 1965. The Summit's Plan of Action, Agenda 21, must also continue to evolve and, despite its shortcomings, is the most extensive and, if implemented, most effective international action ever approved by the international community. Financing the Agenda 21 initiatives remains to be decided. New possible sources of funding must be based n the polluter pays principle and may include new taxes, user charges, emission permits, and citizen funding. Even though the most serious problem in the 1990s is stabilization of atmospheric gases, the Rio agreement does not include targets or timetables. Governments must take united action immediately to reduce carbon dioxide emissions by at least 60%. 1 nation has not yet approved the convention on biological diversity. Governments also need to move forward on conventions on decertification and deforestation. They need to incorporate the global objectives of Agenda 21 into their own national policies and practices. This must also be done at the global, regional, organizational, local, and individual levels. The global community must also begin technology capacity building. The participatory process should also include nongovernmental organizations. Population growth must also slow dramatically to achieve sustainable development. The various participatory levels must consider elimination of poverty.
Biological Stipulations and the Protection of Environmental Resources in the Gulf of Mexico (1985)

This paper documents the growing use of lease stipulations as an impact mitigation procedure in the Gulf of Mexico. In particular, the paper analyzes the role and effectiveness of biological stipulations in protecting such sensitive offshore habitats as the Flower Gardens. The general approach to impact mitigation adopted for the Flower Garden Banks has subsequently been applied to the protection of unique and/or productive communities elsewhere in the Gulf of Mexico.
Enabling context-sensitive information seeking (2006)

Information seeking is an important but often difficult task, especially when it involves large and complex data sets. We hypothesize that a context-sensitive interaction paradigm would greatly assist users in their information seeking. Such a paradigm would allow users to both express their requests and receive requested information in context. Driven by this hypothesis, we have taken rigorous steps to design, develop, and evaluate a full-fledged, context-sensitive information system. We started with a Wizard-of-OZ (WOZ) study to verify the effectiveness of our envi-sioned system. We then built a fully automated system based on the findings from our WOZ study. We targeted the development and integration of two sets of technologies: context-sensitive mul-timodal input interpretation and multimedia output generation. Finally, we formally evaluated the usability of our system in real world conditions. The results show that our system greatly improves the users' ability to perform practical information-seek-ing tasks. These results not only confirm our initial hypothesis, but they also indicate the practicality of our approaches.
Recent technical advances in whole slide imaging instrumentation (2021)

Microscopic observation of biological specimen smears is the mainstay of diagnostic pathology, as defined by the Digital Pathology Association. Though automated systems for this are commercially available, their bulky size and high cost renders them unusable for remote areas. The research community is investing much effort towards building equivalent but portable, low-cost systems. An overview of such research is presented here, including a comparative analysis of recent reports. This paper also reviews recently reported systems for automated staining and smear formation, including microfluidic devices; and optical and computational automated microscopy systems including smartphone-based devices. Image pre-processing and analysis methods for automated diagnosis are also briefly discussed. It concludes with a set of foreseeable research directions that could lead to affordable, integrated and accurate whole slide imaging systems.
Preface (1996)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceBARBARA KNIGHT WARRENBARBARA KNIGHT WARRENUnion Carbide Corporation 3200 Kanawha Turnpike P.O. Box 8361 South Charleston, WV 25303More by BARBARA KNIGHT WARREN and S. TED OYAMAS. TED OYAMADepartment of Chemical Engineering Virginia Polytechnic Institute and State University 133 Randolph Hall Blacksburg, VA 24061More by S. TED OYAMADOI: 10.1021/bk-1996-0638.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):August 13, 1996Publication History Published online23 July 2009Published inprint 13 August 1996Request reuse permissions Copyright © 1996 American Chemical Society. This publication is available under these Terms of Use. Heterogeneous Hydrocarbon Oxidationpp ix-xACS Symposium SeriesVol. 638ISBN13: 9780841234222eISBN: 9780841215870Chapter Views143Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (114 KB) Get e-Alerts