gebhart/patrepeval huggingface dataset:
SETMAR, a case of primate co-opted genes: towards new perspectives (2022)

Our review underlines for the first time that SETMAR directly interacts with genes involved in brain functions related to vocalization and vocal learning. These findings pave the way for future works regarding SETMAR and the development of cognitive abilities in higher primates.
Non-Alcoholic Fatty Pancreas Disease Pathogenesis: A Role for Developmental Programming and Altered Circadian Rhythms (2014)

Fetal and neonatal exposure to a maternal obesogenic environment interacts with a post-natal hyper-calorific environment to induce offspring NAFPD through mechanisms involving perturbations in CCG expression.
On the Influence from Pressing Agent (PEG) on the Elastic and Plastic Mechanical Behavior of Hard Metal Powder Compacts (2023)

During unloading, pressed hard metal powder compacts expand (spring back), leading to unwarranted tensile stresses and, subsequently, crack initiation in the green body. Here, the elastic spring back and the green strength are analyzed for different types and amounts of the pressing agent PEG (polyethylene glycol). The results show that the plastic behavior, but not the elastic behavior, is influenced by a change of the pressing agent PEG. In this context, it should be stated that the risk for the initiation of cracks is influenced by both the elastic and plastic behavior after compaction. The spring back after compaction and the green strength defines to a large extent the risk for cracks. In addition, it is concluded that a standard three-point bending test is sufficient to analyze the risk for the initiation of cracks when comparing different spray-dried powders.
Circulating levels of MCP‐1, sIL‐2R, IL‐15, and IL‐8 predict anemia response to pomalidomide therapy in myelofibrosis (2011)

Cytokine-phenotype associations have recently been described in primary myelofibrosis and increased levels of IL-8, sIL-2R, IL-12, and IL-15 were found to be independently predictive of inferior survival. Pomalidomide therapy is effective for alleviating anemia in myelofibrosis; we examined the relationship between plasma cytokine/chemokine levels and response to treatment with pomalidomide. The study population included 32 Mayo Clinic patients (median age 66 years) who participated in two consecutive clinical trials of pomalidomide therapy for myelofibrosis-associated anemia. Ten (31%) patients achieved anemia response per International Working Group criteria. Anemia response was seen only in the presence of JAK2V617F (P = 0.04) and, in addition, predicted by lower circulating levels of MCP-1 (P = 0.003), IL-2R (P = 0.008), IL-15 (0.01), and IL-8 (P = 0.02). Marked splenomegaly and increased serum LDH level were associated with poor response (P = 0.02 and 0.03, respectively) and with each other (P = 0.02), but not with JAK2V617F. The aforementioned cytokines were not significantly associated with JAK2V617F but increased levels of sIL-2R (P = 0.01), IL-15 (P = 0.06), and MCP-1 (P = 0.07) clustered with marked splenomegaly. Current data suggest that, in the context of pomalidomide treatment, response is more likely in the presence of JAK2V617F and further predicted by the absence of marked splenomegaly or increased levels of proinflammatory cytokines.
Langmuir−Blodgett Films of Biocompatible Poly(HPMA)-block-poly(lauryl methacrylate) and Poly(HPMA)-random-poly(lauryl methacrylate): Influence of Polymer Structure on Membrane Formation and Stability (2010)

Membranes based on functional biocompatible polymers can be regarded as a useful model system to study biological interactions, e.g. antibody-antigen interactions or protein polymer interactions. These model systems may give a better insight into these processes and may help to find suitable polymeric structures offering biocompatibility as well as reduced polymer protein interaction. In this respect, Langmuir-Blodgett (LB) layer formation at the air/water (A/W) interface is studied in respect to polymer architecture in this article. For this purpose, narrowly distributed N-(2-hydroxypropyl)-methacrylamide (HPMA) random and block copolymers have been prepared by the RAFT polymerization method. For random copolymers different molecular weights were prepared. As for the block copolymers also the ratio of hydrophilic and hydrophobic units was varied in order to study the influence of hydrophobic block length on collapse pressure and area. The molecular weights of all polymers were around 15 kDa and 30 kDa. In the case of block copolymers we found a direct correlation of the length of the hydrophobic block to the collapse area. Furthermore, hysteresis experiments clearly point out that block copolymers form stable LB layers. No remarkable changes in collapse pressure or area could be observed. In contrast the area occupied by random copolymers changes at each hysteresis cycle indicating a loss of polymer to the aqueous subphase. In addition the LB layers were transferred onto mica substrates. The block copolymers formed stable and defect free membranes over an area of 100 microm(2) with a roughness (rms) 1.3-1.4 A. On the contrary, membranes based on random copolymers turned out to have a higher surface roughness. Our findings clearly underline the influence of polymer structure on the LB layer formation at the A/W interface.
Sequence-Decoupled Resonant Controller for Three-phase Grid-connected Inverters (2009)

This paper proposes a set of sequence-decoupled resonant controllers constructed with an easy-to-implement structure. It shows that either positive-sequence or negative-sequence components of three-phase unbalanced AC signals can be regulated individually in the stationary frame, while conventional and widely used resonant controllers cannot separately cope with these two sequences. Consequently, the extraction of the corresponding sequence component is not necessary for an individual sequence's control. Moreover, controllers designed for positive and negative sequences can be assigned with different gains to meet practical applications. The principle of new sequence-decoupled resonant controllers is described based on a multi-state-variable structure. In addition, the relation with conventional resonant controllers is investigated. The controllers are found to be equivalent when dealing with both sequences together. Furthermore, two examples are presented to show the application of the proposed controller. The effectiveness of the proposed new controller and its performance in the two system applications are verified by experiments.
Towards nano-scale controlled actuation of cell membrane receptors (2010)

METHODS: To attach EGF on an AFM tip, we need to use a distensible heterobifunctional linker. We chose an 8 nm long PEG linker with an NHS ester on one end for covalent linkage to an amino-coated tip, and a less reactive benzaldehyde at the other end to bind to the Nterminus of EGF. As a quantitative test of the binding of EGF onto an aldehyde group, we incubated two different concentrations of EGF on a glutaraldehyde coated gold layer. We then looked at the surface plasmon resonance (SPR) of this gold layer upon exposure to antibodies against EGF.
Situación de leishmaniasis en España. Años 2019, 2020 y 2021 (2023)

Introducción: La leishmaniasis es una zoonosis endémica en España, donde es causada por Leishmania infantum y transmitida por picadura de Phlebothomus. Puede cursar clínicamente como leishmaniasis cutánea (LC), mucocutánea (LMC) o visceral (LV). El objetivo del estudio fue conocer la situación epidemiológica de leishmaniasis humana en España de 2019 a 2021. Método: Análisis epidemiológico descriptivo de los casos de leishmaniasis notificados a la Red Nacional de Vigilancia Epidemiológica de 2019 a 2021. Se analizaron variables sociodemógraficas (edad, sexo, lugar de residencia), clínicas (categoría clínica, hospitalización, defunción, fecha de síntomas) y de exposición (lugar). Se describió la distribución temporal desde 2016 y se comparó la información de ambos trienios (2019-2021 vs 2016-2018). Resultados: Hubo 1.074 casos notificados, de los que 1.041 fueron autóctonos. La evolución de las tasas de incidencia (TI) de casos autóctonos de 2016 a 2019, fue estable, con descenso marcado en 2020. Las TI más elevadas se observaron en C. Valenciana y Baleares tanto en 2019-2021 como en 2016-2018. El 65,7% fueron hombres, con TI superiores durante todo el período. La mayor TI correspondió a los menores de 1 año y de 1-4 años. El tipo clínico fue LV en el 48,6% de los casos, con diferente distribución porcentual según región. La proporción de hospitalizaciones fue de 49,6%, superior en LV (92,2%) y la tasa de letalidad fue de 1,9%. Hubo 33 casos importados, el 45,5% menores de 15 años procedentes principalmente del Magreb. La proporción de valores perdidos superó el 20% en algunas variables. Conclusiones: la tendencia en los últimos años ha sido estable, con disminución en años pandémicos. La leishmaniasis se distribuye por todo el territorio, con zonas de mayor riesgo en el Mediterráneo. Los grupos de riesgo varían según grupo de edad y sexo. Existe margen de mejora en la cumplimentación y disponibilidad de variables.
Structural Health Monitoring and Damage Prognosis in Fatigue (2008)

A conceptual structural health monitoring (SHM) system to monitor fatigue damage is discussed in this study. The first part of the study is concerned with damage prognosis. A methodology to use the data from a pre-crack damage monitoring system to predict the number of cycles to macrocrack-initiation in a probabilistic sense, is presented. Issues related to quantifying damage, a damage evolution law, and numerical evaluation of the probability of macrocrack initiation are discussed. The second part of the study deals with quantifying the effects of imperfect inspections during the growth of a macrocrack. The probability that there eXists an undetected critical crack is the quantity of interest. An analytical eXpression for this quantity is derived for the case of a two-dimensional crack. A Monte Carlo simulation method to quantify the effects of imperfect inspections is also presented. Numerical results are presented for two eXamples of surface-breaking cracks with different geometries.
Bradykinin Induces Eosinophil Accumulation in the Rat Pleural Cavity (1991)

Intrathoracic injections of bradykinin (1-100 micrograms/cavity) induced a dose-dependent increase in the number of eosinophils recovered from the rat pleural cavity 24 h later. Eosinophilia by bradykinin was preceded by a marked pleural neutrophil influx within 6 h and was absent only 72 h following stimulation. Bradykinin (10(-9)-10(-5) M) failed to induce in vitro eosinophil chemotaxis, indicating that its in vivo effect must be mediated by an intermediate messenger. BW 755C (25 mg/kg) and the more selective lipoxygenase inhibitor BW A4C (20 micrograms/cavity) suppressed the pleural eosinophilia induced by bradykinin (50 micrograms/cavity), whereas the platelet-activating factor (PAF)-acether antagonist BN 52021 was inactive. We conclude that bradykinin is able to attract eosinophil in vivo by a mechanism independent of PAF-acether and sensitive to the blockage of the lipoxygenase pathway.
Oxidative Aryl‐Coupling Reactions in Synthesis (2002)

This chapter contains sections titled: Introduction Mechanistic Overview Oxidative Coupling Reactions with Hypervalent Iodine Reagents Other Reagents for the Oxidative Coupling Reaction Iron(III) Vanadium, Thallium, and Lead Copper(II) Electrochemical Methods Other Metals Non-Metal Mediated Methods Phase-Supported Oxidants Reagents Supported on Inorganic Materials Polymer-Supported Hypervalent Iodine Reagents Control of Atropisomerism Transfer of Chiral Information via the Molecular Backbone Oxidative Coupling of Two Chiral Molecules Stoichiometric Chiral Oxidation Reagents Catalytic Enantioselective Oxidative Coupling Conclusion
Performance on the Wisconsin Card Sorting Test Among Adolescents in Taiwan: Norms, Factorial Structure, and Relation to Schizotypy (2000)

The aims of this study were to assess developmental trends in performance on the Wisconsin Card Sorting Test (WCST) among 817 randomly selected adolescents aged 13-15 years, and to explore WCST performance factor structure and relationship to schizotypy. The results showed that of the nine WCST indexes, only the Categories Achieved and Failure to Maintain Set scores were associated with age, and only the Learning to Learn scores reached adult levels. Factor analysis of WCST performance scores yielded a three-factor structure. Psychometrically defined schizotypic subjects did not perform significantly worse than control subjects on any WCST indexes. These findings suggest that performance on various WCST indexes might indicate developmental changes at different ages, and deficits in WCST performance might not be sensitive indicators of vulnerability to schizophrenia in adolescence.
Particle‐size Distribution of Cowpea Flours Affects Quality of Akara (Fried Cowpea Paste) (2004)

ABSTRACT: Matching of particle‐size distribution and further blending of cowpea paste made from dry milled seeds were used as tools for producing akara of comparable quality to the traditional West African wet‐milled product. All blended samples showed a reduction in viscosity after whipping ranging from 48.2% to 54.2%. HM‐1.73 (Hammer mill with 1.73‐mm screen) produced the least number (11) of akara balls per batch with highest per ball weight (20.93 g). Akara fat content varied from 14.7% to 33.1%. Akara made from HM‐2.54 (hammer mill with 2.54‐mm screen) contained 21.1% fat and was acceptable to consumers.
MoS 2 monolayers on nanocavities: enhancement in light–matter interaction (2016)

Two-dimensional (2D) atomic crystals and van der Waals heterostructures constitute an emerging platform for developing new functional ultra-thin electronic and optoelectronic materials for novel energy-efficient devices. However, in most thin-film optical applications, there is a long-existing trade-off between the effectiveness of light–matter interactions and the thickness of semiconductor materials, especially when the materials are scaled down to atom thick dimensions. Consequently, enhancement strategies can introduce significant advances to these atomically thick materials and devices. Here we demonstrate enhanced absorption and photoluminescence generation from MoS2 monolayers coupled with a planar nanocavity. This nanocavity consists of an alumina nanolayer spacer sandwiched between monolayer MoS2 and an aluminum reflector, and can strongly enhance the light–matter interaction within the MoS2, increasing the exclusive absorption of monolayer MoS2 to nearly 70% at a wavelength of 450 nm. The nanocavity also modifies the spontaneous emission rate, providing an additional design freedom to control the interaction between light and 2D materials.
Resource management in the mpC programming environment (2002)

The mpC (message-passing C) language was developed to write efficient and portable programs for wide range of distributed memory machines. It supports both task and data parallelism, allows both static and dynamic process and communication structures, enables optimizations aimed at both communication and computation, and supports modular parallel programming and the development of a library of parallel programs. The language is an ANSI C superset based on the notion of a network comprising processor nodes of different types and performances, connected with links of different bandwidths. The user can describe a network topology, create and discard networks, and distribute data and computations over networks. The mpC programming environment uses the topological information at run-time to ensure the efficient execution of the application. This paper describes the implementation of network management in the mpC programming environment.
Complexity-scalable algorithmic design: implementation of a scalable resolution enhancement algorithm (2003)

A complexity scalable algorithm is an algorithm that has several computation scales with gracefully degraded qualities from the original quality. We present the importance of, and the design principles and guidelines for, making a scalable algorithm. We then use a resolution enhancement algorithm as an example and make it scalable. The resulting scalable algorithm has 5 computation scales, consisting of 35%, 31%, 23%, 16%, and 0% of the original optimized computation with very-good quality compared to the non-enhanced quality. This scalable algorithm has many applications in multi-feature multimedia HD (high definition) devices.
Corpus Cavernosum Electromyography with Revised Methodology: An Explorative Study in Patients with Erectile Dysfunction and Men with Reported Normal Erectile Function (2007)

Corpus cavernosum electromyography performed with the revised methodology is able to discriminate ED patients with conditions that are associated with cavernous smooth muscle degeneration and/or autonomic neuropathy from men with reported normal erectile function.
Effects of sleep deprivation on fos-like immunoreactivity in the rat brain. (1992)

The molecular mechanisms involved in sleep regulation and function are largely unknown, and our understanding of the localization of such mechanisms within specific brain structures is still incomplete. In this work, we explored the consequences of sleep deprivation by the immunocytochemical mapping of the induction of the protein product of the immediate early gene c-fos in the brain of sleep-deprived rats. The expression of Fos protein is an indicator of neuronal activity. In addition, since immediate early genes can function as "third messengers" and regulate the transcription of a number of target genes, their induction could be directly relevant to the homeostasis and functions of sleep. The present results show that, as a result of 24 hours of manual sleep deprivation, Fos-like immunoreactive cells are found in specific brain areas. These areas include the medial preoptic area of the hypothalamus, the nucleus accumbens, the lateral septum, several regions of the dorsal pontine tegmentum (central gray, dorsal raphe, locus coeruleus, pedunculopontine and laterodorsal tegmental nuclei, parabrachial nuclei) and an area medial to the parabigeminal nucleus at the ponto-mesencephalic junction. Some of these areas had already been implicated in slow-wave sleep and desynchronized sleep regulation.
Monoclonal antibodies specific for porcine monocytes/macrophages: macrophage heterogeneity in the pig evidenced by the expression of surface antigens (1997)

Macrophages are widely distributed in most tissues of the body, where they play important roles in host defense and repair of tissue damage. In this report we describe the production and characterization of a panel of six monoclonal antibodies (mAb) against porcine macrophages and their use for phenotyping tissue macrophages. All mAbs were produced by immunizing mice with porcine alveolar macrophages. Three of them (2A10/11, 3B11/11 and 3F7/11) react mainly with macrophages and, at a lower extent, blood monocytes, whereas the others (1E12/11, 2C12/10 and 4E9/11) also recognize granulocytes. Antigens recognized by these antibodies could be characterized by Western blot and/or immunoprecipitation, with the exception of that one recognized by 2C12/10. By their behavior in SDS-PAGE under reducing and nonreducing conditions, all seem to be single polypeptides, whose apparent molecular weight under reducing conditions are: 1E12/11 and 3B11/11 larger than 204 kDa; 2A10/11, 150 kDa; 4E9/11, 125-170 kDa; and 3F7/11, 135 kDa. Immunohistochemical analyses of both lymphoid and non-lymphoid organs using these mAbs reveal important antigenic heterogeneity among tissue macrophages. These mAbs are, therefore, useful tools for the study of porcine macrophage maturation and differentiation and for determining their heterogeneity both in normal and pathological conditions.
HIGH RESOLUTION EDDY-CURRENT WIRE TESTING BASED ON A GMR SENSOR-ARRAY (2009)

Increasing demands in materials quality and cost effectiveness have led to advanced standards in manufacturing technology. Especially when dealing with high quality standards in conjunction with high throughput quantitative NDE techniques are vital to provide reliable and fast quality control systems. In this work we illuminate a modern electromagnetic NDE approach using a small GMR sensor array for testing superconducting wires. Four GMR sensors are positioned around the wire. Each GMR sensor provides a field sensitivity of 200 pT/Hz and a spatial resolution of about 100 μm. This enables us to detect under surface defects of 100 μm in size in a depth of 200 μm with a signal‐to‐noise ratio of better than 400. Surface defects could be detected with a SNR of up to 10,000. Besides this remarkably SNR the small extent of GMR sensors results in a spatial resolution which offers new visualisation techniques for defect localisation, defect characterization and tomography‐like mapping techniques. We also report on inverse algorithms based on either a Finite Element Method or an analytical approach. These allow for accurate defect localization on the urn scale and an estimation of the defect size.
A High Resolution Detection System for Positron Tomography (1983)

The feasibility of using a hybrid detection system, consisting of multiple narrow bismuth germanate (BGO) crystals coupled to one photomultiplier for coincidence timing, and individual mercuric iodide (HgI2) photodetectors coupled to each BGO crystal to identify crystals of interaction, was investigated for application to positron tomography. The match between the emission spectrum of BGO and the photoresponse spectrum of HgI2 in combination with recently developed HgI2 x-ray detector and low noise preamplifier technology provided the appropriate high sensitivity, low noise environment required to detect the low levels of scintillation light produced in the absorption of 511 keV gamma-rays in BGO. Energy resoluton of 24% for 511 keV was obtained with the BGO-HgI2 detector, compared to 18% for BGO with a PMT. Coincidence resolving time for the HgI2-BGO detector was measured to be 105 nanoseconds. This performance of a non-optimized detector system is nominally adequate for appropriately designed tomographs.
Automated Toll Gate Passing (2018)

This paper proposes a new approach of automated toll gate passing of an automated driving vehicle. This approach enables the vehicle to select an optimal toll gate and to automatically pass the toll gate by using object detection, 3D environment construction, virtual line generation, path planning and motion control. After designing the concept of the approach, some demonstrations are conducted to prove it. This data-based scenario shows that the proposed approach can not only perceive the environment well for this purpose but can also plan appropriate trajectories when encountering complex scene near toll plazas.