gebhart/patrepeval huggingface dataset:
Outcomes of Children With BCR-ABL1 –Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease (2014)

Patients who have BCR-ABL1–like ALL with poor initial treatment response can be salvaged with MRD-based risk-directed therapy and may benefit from identification of kinase-activating lesions for targeted therapies.
Intrusion Techniques: Comparative Study of Network Intrusion Detection Systems (2008)

Organizations require security systems that are flexible and adaptable in order to combat increasing threats from software vulnerabilities, virus attacks and other malicious code, in addition to internal attacks. Network intrusion detection systems, which are part of the layered defense scheme, must be able to meet these organizational objectives in order to be effective. Although signature based network intrusion detection systems meet several organizational security objectives, heuristic based network intrusion detection systems are able to fully meet the objectives of the organization. Through a comparative theoretical study, this paper analyzes several organizational security objectives in order to determine the network intrusion detection system that effectively meets these objectives. Through conclusive analysis of the study, heuristic based systems are better served to meet the organizational objectives than signature based systems. The analysis was based on which system provided definitive security objectives and offered the flexibility, adaptability, and reduced vulnerability that an organization requires.
Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies (2021)

There is general agreement that auto-antibodies against ion channels and synaptic machinery proteins can induce limbic encephalitis. In immune-mediated cerebellar ataxias (IMCAs), various synaptic proteins, such as GAD65, voltage-gated Ca channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluR delta) are auto-immune targets. Among them, the pathophysiological mechanisms underlying anti-VGCC, anti-mGluR1, and anti-GluR delta antibodies remain unclear. Despite divergent auto-immune and clinical profiles, these subtypes show common clinical features of good prognosis with no or mild cerebellar atrophy in non-paraneoplastic syndrome. The favorable prognosis reflects functional cerebellar disorders without neuronal death. Interestingly, these autoantigens are all involved in molecular cascades for induction of long-term depression (LTD) of synaptic transmissions between parallel fibers (PFs) and Purkinje cells (PCs), a crucial mechanism of synaptic plasticity in the cerebellum. We suggest that anti-VGCC, anti-mGluR1, and anti-GluR delta Abs-associated cerebellar ataxias share one common pathophysiological mechanism: a deregulation in PF-PC LTD, which results in impairment of restoration or maintenance of the internal model and triggers cerebellar ataxias. The novel concept of LTDpathies could lead to improvements in clinical management and treatment of cerebellar patients who show these antibodies.
Forecasting in the NBA and other team sports (2012)

The multi-million sports-betting market is based on the fact that the task of predicting the outcome of a sports event is very hard. Even with the aid of an uncountable number of descriptive statistics and background information, only a few can correctly guess the outcome of a game or a league. In this work, our approach is to move away from the traditional way of predicting sports events, and instead to model sports leagues as networks of players and teams where the only information available is the work relationships among them. We propose two network-based models to predict the behavior of teams in sports leagues. These models are parameter-free, that is, they do not have a single parameter, and moreover are sport-agnostic: they can be applied directly to any team sports league. First, we view a sports league as a network in evolution, and we infer the implicit feedback behind network changes and properties over the years. Then, we use this knowledge to construct the network-based prediction models, which can, with a significantly high probability, indicate how well a team will perform over a season. We compare our proposed models with other prediction models in two of the most popular sports leagues: the National Basketball Association (NBA) and the Major League Baseball (MLB). Our model shows consistently good results in comparison with the other models and, relying upon the network properties of the teams, we achieved a ≈ 14% rank prediction accuracy improvement over our best competitor.
Recognition of Complex Core‐Fucosylated N‐Glycans by a Mini Lectin (2018)

Abstract The mini fungal lectin PhoSL was recombinantly produced and characterized. Despite a length of only 40 amino acids, PhoSL exclusively recognizes N‐glycans with α1,6‐linked fucose. Core fucosylation influences the intrinsic properties and bioactivities of mammalian N‐glycoproteins and its level is linked to various cancers. Thus, PhoSL serves as a promising tool for glycoprofiling. Without structural precedence, the crystal structure was solved using the zinc anomalous signal, and revealed an interlaced trimer creating a novel protein fold termed β‐prism III. Three biantennary core‐fucosylated N‐glycan azides of 8 to 12 sugars were cocrystallized with PhoSL. The resulting highly resolved structures gave a detailed view on how the exclusive recognition of α1,6‐fucosylated N‐glycans by such a small protein occurs. This work also provided a protein consensus motif for the observed specificity as well as a glimpse into N‐glycan flexibility upon binding.
Determination of crystallinity in polyethylene by X‐ray diffractometer (1955)

Abstract A convenient and rapid x‐ray diffraction method is described for the determination of per cent crystallinity in polyethylene, using a scanning goniometer with Geiger tube and scaler counter. Results are presented on per cent crystallinities of a number of polyethylenes and on samples made by quenching polyethylene melt at different temperatures in the range of 20–102°C. The samples of polyethylene studied were found to have 65‐71% crystallinity. The temperature at which plyethylene melt is quenched has no appreciable effect on the crystalline content.
The mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles (2014)

The Chrysochromulina tobin organellar genomes provide new insight into organellar function and evolution. These are the first organellar genomes to be determined for the prymnesiales, a taxon that is present in both oceanic and freshwater systems and represents major primary photosynthetic producers and contributors to global ecosystem stability.
Aerobic and cardiovascular autonomic adaptations to moderate intensity endurance exercise in patients with fibromyalgia (2015)

Female patients with fibromyalgia have similar cardiovascular adaptations to moderate intensity endurance exercise as healthy controls.
Resonant cavity enhanced InAs∕In0.15Ga0.85As dots-in-a-well quantum dot infrared photodetector (2007)

The authors demonstrate the design, growth, fabrication, and characterization of resonant cavity enhanced InAs∕In0.15Ga0.85As dots-in-a-well (RC-DWELL) quantum dot infrared photodetector (QDIP) and compare it with a standard DWELL detector. They measured peak photoresponse at the resonant wavelength of 9.5μm for the RC-DWELL photodetector. The peak responsivity was measured to be 0.76A∕W at 1.4V and the peak detectivity was 1.4×1010cmHz1∕2∕W at 0.5V at a temperature of 77K. The photocurrent density increased in comparison with the standard DWELL structure with the same active region by a factor of 6 at Vb=2.1V and 80K. A factor of 6 increase in responsivity and factor of 3 increase in detectivity at 1.2V and 77K were also observed in the resonant cavity enhanced DWELL sample. The quantum efficiencies for the RC-DWELL sample were calculated to be ∼10% at 9.5μm and 1.25% at 10μm for the standard DWELL sample. They conclude that the RC-DWELL is a promising improvement for QDIP-based infrared detection applications.
Code assignment for hidden terminal interference avoidance in multihop packet radio networks (1995)

Hidden terminal interference is caused by the (quasi-) simultaneous transmission of two stations that cannot hear each other, but are both received by the same destination station. This interference lowers the system throughput and increases the average packet delay. Some random access protocols that reduce this interference have been proposed, e.g., BTMA protocol. However, the hidden terminal interference can be totally avoided only by means of code division multiple access (CDMA) schemes. In the paper, the authors investigate the problem of assigning orthogonal codes to stations so as to eliminate the hidden terminal interference. Since the codes share the fixed channel capacity allocated to the network in the design stage, their number must not exceed a given bound. The authors seek assignments that minimize the number of codes used. They show that this problem is NP-complete, and thus computationally intractable, even for very restricted but very realistic network topologies. Then, they present optimal algorithms for further restricted topologies, as well as fast suboptimal centralized and distributed heuristic algorithms. The results of extensive simulation set up to derive the average performance of the proposed heuristics on realistic network topologies are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Aircraft measurements of bromine monoxide, iodine monoxide, and glyoxal profiles in the tropics: comparison with ship-based and in situ measurements (2015)

Abstract. Tropospheric chemistry of halogens and organic carbon over tropical oceans modifies ozone and atmospheric aerosols, yet atmospheric models remain largely untested for lack of vertically resolved measurements of bromine monoxide (BrO), iodine monoxide (IO), and small oxygenated hydrocarbons like glyoxal (CHOCHO) in the tropical troposphere. BrO, IO, glyoxal, nitrogen dioxide (NO2), water vapor (H2O) and O2-O2 collision complexes (O4) were measured by the CU Airborne Multi AXis Differential Optical Absorption Spectroscopy (CU AMAX-DOAS) instrument, in situ aerosol size distributions by an Ultra High Sensitivity Aerosol Spectrometer (UHSAS), and in situ H2O by Vertical-Cavity Surface-Emitting Laser hygrometer (VCSEL). Data are presented from two research flights (RF12, RF17) aboard the NSF/NCAR GV aircraft over the tropical Eastern Pacific Ocean (tEPO) as part of the "Tropical Ocean tRoposphere Exchange of Reactive halogens and Oxygenated hydrocarbons" (TORERO) project. We assess the accuracy of O4 slant column density (SCD) measurements in the presence and absence of aerosols, and find O4-inferred aerosol extinction profiles at 477 nm agree within 5% with Mie calculations of extinction profiles constrained by UHSAS. CU AMAX-DOAS provides a flexible choice of geometry which we exploit to minimize the SCD in the reference spectrum (SCDREF, maximize signal-to-noise), and to test the robustness of BrO, IO, and glyoxal differential SCDs. The RF12 case study was conducted in pristine marine and free tropospheric air. The RF17 case study was conducted above the NOAA RV Ka'imimoana (TORERO cruise, KA-12-01), and provides independent validation data from ship-based in situ Cavity Enhanced- and MAX-DOAS. Inside the marine boundary layer (MBL) no BrO was detected (smaller than 0.5 pptv), and 0.2–0.55 pptv IO and 32–36 pptv glyoxal were observed. The near surface concentrations agree within 20% (IO) and 10% (glyoxal) between ship and aircraft. The BrO concentration strongly increased with altitude to 3.0 pptv at 14.5 km (RF12, 9.1 to 8.6° N; 101.2 to 97.4° W). At 14.5 km 5–10 pptv NO2 agree with model predictions, and demonstrate good control over separating tropospheric from stratospheric absorbers (NO2 and BrO). Our profile retrievals have 12–20 degrees of freedom (DoF), and up to 500 m vertical resolution. The tropospheric BrO VCD was 1.5 × 1013 molec cm−2 (RF12), and at least 0.5 × 1013 molec cm−2 (RF17, 0–10 km, lower limit). Tropospheric IO VCDs correspond to 2.1 × 1012 molec cm−2 (RF12) and 2.5 × 1012 molec cm−2 (RF17), and glyoxal VCDs of 2.6 × 1014 molec cm−2 (RF12) and 2.7 × 1014 molec cm−2 (RF17). Surprisingly, essentially all BrO, and the dominant IO and glyoxal VCD fraction was located above 2 km (IO: 58 ± 5%, 0.1–0.2 pptv; glyoxal: 52 ± 5%, 3–20 pptv). To our knowledge there are no previous vertically resolved measurements of BrO and glyoxal from aircraft in the tropical free troposphere.
Novel Food Technologies: Enhancing Appetite Control in Liquid Meal Replacers (2006)

Abstract MELA, DAVID J. Novel food technologies: enhancing appetite control in liquid meal replacers.
Two Roomtemperature‐stable Trications – Triprotonated Triamino‐ and Tricyanobenzene (2022)

Protonation of 1,3,5-tricyano- and 1,3,5-triaminobenzene was achieved in various superacidic media, resulting in the formation of the respective trinitrilium and triammonium species. Furthermore, the respective N-methyl nitrilium species was synthesized by methylation. Characterization was performed by NMR and vibrational spectroscopy, followed by single-crystal X-ray diffraction analyses of selected species. Fourfold protonation of the amine, which would have led to the triammonium arenium species, could not be achieved. Quantum chemical calculations are employed to enable full vibrational assignment as well to quantify charge localization.
<title>Optical implementation of a parallel out-of-band controller for large broadband ATM switch applications</title> (1996)

Asynchronous transfer mode (ATM) is rapidly becoming the transport mechanism of choice for the information superhighway, because it promises the bandwidth and flexibility needed for many voice, video and data service offerings. Some industry experts project that the required sizes for ATM switching equipment in the public-switched environment will reach the Tbps range by the beginning of the next decade. This paper analyzes the problems associated with controlling the flow of packets within a broadband ATM switch of this size. The analysis is based on the requirements of the growable packet switch architecture. The paper proposes a novel solution to the problem of hunting paths within an ATM packet switch network. The resulting control scheme is unconventional in two ways. First, it uses an out-of-band control algorithm instead of the more common self-routing approach. In particular, we explore the benefits of using a parallel processor as an out-of-band controller for a growable packet switch distribution network. The processor permits additional levels of parallelism to be added to the out-of-band control function so that path hunts can be performed for all N of the input ports within a single cell interval. The proposed approach is also unconventional because it uses free-space digital optics to guide signals between successive stages of the controller. The paper describes the underlying motivations for implementing an optical out-of-band controller for an ATM switch, and it also describes the logic within a controller node that has been fabricated using a hybrid Si CMOS/GaAs SEED technology. The node uses optical detectors (in GaAs), amplifiers and digital control logic (in Si), and optical modulators (in GaAs). Free-space optical connections between successive device arrays can be provided using either bulk optical elements or micro-optics, but the optical interconnects must provide massive fanout capability. An architectural analysis studying the feasibility of applying free-space optics in this proposed ATM switch controller also is presented.
Effet d'une souche de Lactobacillus sur la cinétique d'établissement de Shigella flexneri et d'Escherichia coli dans le tube digestif de souriceaux "Gnotoxéniques." Rôle de l'immunisation des mères (1973)

A strain of either Shigella flexneri, Escherichia coli, or each of these two strains with a strain of Lactobacillus is implanted in the digestive tract of different couples of axenic adult mice.Some pregnant mothers are vaccinated with the three strains before implantation. The vaccination does not change the kinetics establishment of all three bacterial strains in either the mothers or the young.Escherichia coli is established at its maximum level in "monoxenic" young mice at day 3 after birth, while Shigella appears slowly and irregularly during the 1st week of life. Both strains are established almost simultaneously in the stomach and intestine of the young mice.Lactobacillus is established at maximum level in the stomach and intestine of "dixenic" young mice at day 1 after birth. In these conditions, Shigella appears slowly, only reaching maximum level at 17 days. This antagonistic effect is especially observed in the stomach of the animals, and in a small measure, in the intestine. The establishment of E. coli is hardly affected by the presence of Lactobacillus, except in the stomach in most young animals.In no case is there interference between Lactobacillus and either one of the two strains after 3 weeks of age.
Fluorine-19 NMR studies on 8-fluoroflavins and 8-fluoro flavoproteins (1990)

The 19F NMR spectra of the oxidized and reduced forms of 8-fluororiboflavin, 8-fluoro-FAD, and the 8-fluoroflavin-reconstituted flavoproteins flavodoxin, riboflavin binding protein, D-amino acid oxidase, p-hydroxybenzoate hydroxylase, Old Yellow Enzyme, anthranilate hydroxylase, general acyl-CoA dehydrogenase, glucose oxidase, and L-lactate oxidase were measured. For the proteins studied the oxidized resonances appeared over a 10.1-ppm range, while the reduced resonances were spread over 10.3 ppm. Reduction caused an upfield shift of about 27 ppm for the free 8-fluoroflavins and most of the 8-fluoro flavoproteins. The notable exception was 8-fluoro-FMN flavodoxin, which was shifted 37.6 ppm, indicating an unusually high electron density in the benzene ring. Ligand binding to the oxidized 8-fluoro flavoproteins caused either upfield or downfield shifts of 1.5-5 ppm, depending on the protein/ligand combination. The 8-fluoro-FAD anthranilate hydroxylase resonance was shifted downfield and split into two peaks in the presence of anthranilate. The 8-fluoro-FMN Old Yellow Enzyme resonance was shifted upfield upon complexation with charge-transfer-forming, para-substituted phenolates. The upfield shift increased from less than 1 to 5 ppm as the electron-donating capacity of the phenolate increased. Complexation of native Old Yellow Enzyme with 2,4-difluorophenol caused the fluorine resonances of the ligand to shift and split into two pairs of signals. Each pair of signals was associated with a different isozyme of Old Yellow Enzyme.
qPCR analysis of mesenchymal stem cell marker expression during the long-term culture of canine adipocyte derived stem cells (2020)

Abstract Due to its availability and accessibility, adipose tissue has been the subject of various studies in many different medical fields and is believed to be a useful source of stem cells. The ability of ASCs to differentiate towards different cell lineages, with possibility of directing this differentiation, increases their possible clinical applications, and they have been widely employed in multiple therapies and treatment of different pathologies. However, a deeper understanding of the molecular mechanisms underlying the ASCs osteoblastic and chondrocyte differentiation may lead to novel applications treating a multitude of different bone-related diseases through techniques more likely meeting worldwide consensus. In this study, the RT-qPCR method was used to determine the changes in expression of ASC specific markers (CD105, CD73, CD14, CD34, CD90 and CD45) before and after long-term (14-day) in vitro cultures. To confirm the identity of the investigated cells, flow cytometry was used to evaluate the presence of positive (CD44, CD90) and negative (CD45, CD34) ASC markers. Overall, the results of the PCR analysis showed a significant change in expression of most of the marker genes, indicating significant changes in the cultured cells caused by their long-term culture, potentially altering their original stem-like characteristics. Running title : ASC marker expression during long-term in vitro culture
Automated Adaptive Forming Simulations. (2003)

In this study, an automated adaptive mesh control scheme, based on local mesh modifications, is developed for the finite element simulations of 3D metal forming processes. Error indicators are used to control the mesh discretization errors, and a consecutive h-adaptive procedure is conducted. The mesh size field used in the h-adaptive procedure is processed to control the geometric approximation errors on the evolving workpiece boundary mesh. During the simulations the workpiece mesh is adaptively enriched whenever the mesh is no longer acceptable. Industrial problems are investigated to demonstrate the capabilities of the developed scheme.
Overcoming Fitness, Symptom, And Behavior Barriers After A Physical Activity Intervention With Fitness Graded Motion Exergames (PAfitME) Among Head And Neck Cancer Patients (2019)

PURPOSE: Routinely engaging physical activity (PA) leads to better health outcomes in cancer survivors. Over 50% of head and neck cancer (HNC) survivors rarely engage in any type of PA because of the barriers of impaired fitness, severe symptoms, and poor self-efficacy (SE). A personalized telehealth Physical Activity intervention with fitness graded Motion Exergames (PAfitME) was designed to overcome these barriers. In our pilot study, we found the HNC patients fully adhered with the personalized exergame prescription in the 6-week PAfitME intervention. The purpose of this study was to examine changes in barriers: fitness (gait speed), symptoms, and SE among HNC patients participating in the PAfitME intervention. METHODS: A pre/post-test design was used to test the 6-week PAfitME intervention. Personalized exergame prescriptions were developed and progressed based on the social cognitive theory and exercise principal of adaptation. Fitness was measured by preferred gait speed (m/s). Symptom data were collected via the MD Anderson Symptom Inventory, Brief Pain Inventory, Pittsburg Sleep Quality Index, General Anxiety Disorder scale, and Center for Epidemiologic Studies Depression Scale. SE was measured by the PA Self-Efficacy scale (0-100%). Descriptive statistics and paired t tests were applied. RESULTS: A total of 10 HNC participants were recruited. Two participants dropped out due to recurrence. The mean age was 58.2 years old (n=8). Seven (88%) were male. Three (38%) had oral cancer and 5 (63%) had laryngeal cancer. Three (38%) had a feeding tube and 2 (25%) had a tracheostomy. Four (50%) had stage III/IV cancer. Mean gait speed improvement was clinically significant (0.11m/s). There were positive improvements in 17 of 20 symptoms with significant decreases in pain (t=2.34, p=0.05), in fatigue (t=3.64, p=0.008) and in difficulty with voice/speech (t=2.35, p=0.05). Seven participants (88%) had 100% SE to do their personalized exergame prescription in the post test. CONCLUSIONS: This study shows HNC participants overcame their PA barriers after the PAfitME intervention. It also supports the need for a larger randomized clinical trial for efficacy testing. The positive impact from PAfitME will shift PA interventions from a standardized protocol to a personalized, behavioral telehealth approach.