gebhart/patrepeval huggingface dataset:
Heterometallic boride clusters: synthesis and characterization of butterfly and square pyramidal boride clusters* (2017)

Abstract A number of heterometallic boride clusters have been synthesized and structurally characterized using various spectroscopic and crystallographic analyses. Thermolysis of [Ru 3 (CO) 12 ] with [Cp*WH 3 (B 4 H 8 )] ( 1 ) yielded [{Cp*W(CO) 2 } 2 ( μ 4 -B){Ru(CO) 3 } 2 ( μ -H)] ( 2 ), [{Cp*W(CO) 2 } 2 ( μ 5 -B){Ru(CO) 3 } 2 {Ru(CO) 2 }( μ -H)] ( 3 ), [{Cp*W(CO) 2 }( μ 5 -B){Ru(CO) 3 } 4 ] ( 4 ) and a ditungstaborane cluster [(Cp*W) 2 B 4 H 8 Ru(CO) 3 ] ( 5 ) (Cp*= η 5 -C 5 Me 5 ). Compound 2 contains 62 cluster valence-electrons, in which the boron atom occupies the semi-interstitial position of a M 4 -butterfly core, composed of two tungsten and two ruthenium atoms. Compounds 3 and 4 can be described as hetero-metallic boride clusters that contain 74-cluster valence electrons (cve), in which the boron atom is at the basal position of the M 5 -square pyramidal geometry. Cluster 5 is analogous to known [(Cp*W) 2 B 5 H 9 ] where one of the BH vertices has been replaced by isolobal {Ru(CO) 3 } fragment. Computational studies with density functional theory (DFT) methods at the B3LYP level have been used to analyze the bonding of the synthesized molecules. The optimized geometries and computed 11 B NMR chemical shifts satisfactorily corroborate with the experimental data. All the compounds have been characterized by mass spectrometry, IR, 1 H, 11 B and 13 C NMR spectroscopy, and the structural architectures were unequivocally established by crystallographic analyses of clusters 2–5 .
Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms (2012)

The Kelch-like 1 protein (KLHL1) is a neuronal actin-binding protein that modulates calcium channel function. It increases the current density of Ca(v)3.2 (α(1H)) calcium channels via direct interaction with α(1H) and actin-F, resulting in biophysical changes in Ca(v)3.2 currents and an increase in recycling endosomal activity with subsequent increased α(1H) channel number at the plasma membrane. Interestingly, removal of the actin-binding Kelch motif (ΔKelch) prevents the increase in Ca(v)3.2 current density seen with wild-type KLHL1 when tested with normal square pulse protocols but does not preclude the effect when tested using action potential waveforms (AP). Here, we dissected the kinetic properties of the AP waveform that confer the mutant Kelch the ability to interact with Ca(v)3.2 and induce an increase in calcium influx. We modified the action potential waveform by altering the slopes of repolarization and/or recovery from hyperpolarization or by changing the duration of the depolarization plateau or the hyperpolarization phase and tested the modulation of Ca(v)3.2 by the mutant ΔKelch. Our results show that the recovery phase from hyperpolarization phase determines the conformational changes that allow the α(1H) subunit to properly interact with mutant KLHL1 lacking its actin-binding Kelch domains, leading to increased Ca influx.
Patterning and characterization of large-area quantum wire arrays (1991)

Large-area arrays of parallel quantum wires of 30–80 nm width are achieved using a combination of x-ray lithography, wet chemical etching, and low-pressure metalorganic vapor phase epitaxy. The quantum wires are characterized using low-temperature photoluminescence and magnetotransport measurements. The quantum confinement is reflected in a clear blue shift in the luminescence peak, and in deviation from the periodicity of the Shubnikov–de Haas oscillations as a function of inverse magnetic field.
Transport intestinal de la gluamine et effets de la glutamine sur le transport ionique. Interrelations avec le metabolisme proteique (1992)

Le transport intestinal de la glutamine et ses interrelations metaboliques avec les autres acides amines et le metabolisme proteique ont ete etudies in vitro sur l'ileon de lapin sain et infecte par rdec-1, et in vivo chez l'homme. L'absorption intestinale de la glutamine est active, saturable, et couplee au transport electrogenique de sodium. Chez l'homme, l'absorption est tres intense sur un court segment de jejunum, refletant une capacite maximale d'absorption elevee, qui n'est pas modifiee lors d'une hypersecretion induite par la pge1. La glutamine stimule l'absorption de sodium et de chlore; cet effet et celui du glucose sont additifs. Chez l'homme, l'administration enterale de glutamine augmente la production endogene d'alanine et les concentrations plasmatiques d'alanine, ornithine, citrulline et aspartate, refletant le metabolisme intestinal d'une partie de la glutamine; une fraction echappe toutefois a ce metabolisme, entrainant une elevation de la glutaminemie. Chez l'homme sain a jeun, la glutamine administree par voie enterale ne modifie pas le metabolisme glucidique ni la proteolyse, mais inhibe la lipolyse. Chez l'homme a jeun, la leucine issue de la proteolyse musculaire est un precurseur important de la synthese de novo de glutamine endogene. Ces resultats apportent des bases physiologiques a l'administration de glutamine par voie enterale chez l'homme
Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver. (1994)

Two cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in chick embryo liver microsomes were purified. The P-450s exhibit catalytic selectivity either for arachidonic acid metabolism, particularly epoxygenation (P-450 TCDDAA, 55 kDa), or for aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin deethylase (7-EROD) (P-450 TCDDAHH, 54.5 kDa). Turnover numbers for arachidonic acid epoxygenation, AHH, and 7-EROD, respectively, were 24.2, 0.23, and 0.45 for TCDDAA and 0.57, 9.7, and 35.5 for TCDDAHH. Both P-450s were low spin, with carbon monoxide-binding peaks at 448 nm. Their N-terminal amino acid sequences showed 80% homology and contained the sequence: PXXXSATEXL, common to CYP1A P-450s but not others. Polyclonal antibodies to TCDDAA and TCDDAHH cross-reacted with both P-450s on Western blots and immunoinhibited all TCDD-induced liver microsomal arachidonic acid metabolism, AHH, and 7-EROD. Immunoquantitation using antibodies made monospecific by immunoadsorption against the heterologous P-450 showed that TCDDAA and TCDDAHH were coinduced in liver in equal amounts and accounted for all of the TCDD-induced P-450. Enzyme assays and Western blots also showed expression of both TCDDAA and TCDDAHH in kidney but only of TCDDAHH in heart, indicating that these P-450s can be independently regulated and selectively induced. On Western blots non-immunopurified anti-TCDDAA and anti-TCDDAHH antisera recognized rat and guinea pig CYP1A1 and CYP1A2. Immunopurified TCDDAA antiserum only recognized rat CYP1A2, indicating that TCDDAA is more closely related immunochemically to CYP1A2 than to CYP1A1. The evidence that pleotropic responses to Ah receptor ligands can include induction of a P-450 that can form biologically active products from the endogenous membrane lipid, arachidonic acid, suggests that organ- and cell-specific expression of TCDD-induced P-450s could affect responses to TCDD.
Evaluating the use of line length for automatic sleep spindle detection (2014)

Sleep spindles are transient waveforms observed on the electroencephalogram (EEG) during the N2 stage of sleep. In this paper we evaluate the use of line length, an efficient and low-complexity time domain feature, for automatic detection of sleep spindles. We use this feature with a simple algorithm to detect spindles achieving sensitivity of 83.6% and specificity of 87.9%. We also present a comparison of these results with other spindle detection methods evaluated on the same dataset. Further, we implemented the algorithm on a MSP430 microcontroller achieving a power consumption of 56.7 μW. The overall detection performance, combined with the low power consumption show that line length could be a useful feature for detecting sleep spindles in wearable and resource-constrained systems.
Nonprocess-element control in the liquor cycle using an ash leaching system (2010)

To lengthen run time between washes and reduce thermal cycling of the recovery boiler, the Evadale, Texas, mill has been attempting to reduce the levels of nonprocess elements (NPEs) in the liquor cycle. The mill has periodically purged electrostatic precipitator ash in an effort to reduce and control potassium (K) and chloride (Cl) concentrations. Additional efforts to lower chloride concentrations involved changing the makeup chemical from diaphragm- to membrane-grade caustic and improving the operation of the chlorine dioxide generator spent acid salt filter. The change in makeup chemical NPE content successfully reduced the amount of boiler plugging due to sticky ash formation, but did not provide the desired amount of time between boiler washes. In an effort to further reduce the amounts of potassium and chloride in the liquor cycle, an ash leaching system was installed. The leaching system partially dissolves precipitator ash in hot water. The potassium and chloride are selectively leached into the liquid phase and remain in solution. Sodium sulfate crystals are separated from the leaching slurry using a decanting centrifuge and returned to the liquor cycle via a mix tank. The potassium- and chloride-rich liquid is sewered. Since the implementation of these nonprocess-element reduction methods, the chloride content of the incoming electrostatic precipitator ash has been reduced by roughly 55% and the potassium content by approximately 50%. Approximately 80% of the soda entering the ash leaching process is recovered into the liquor cycle.
Predicting Air Classifier Performance (1983)

A test predicting air classifier performance is developed and evaluated in a waste‐to‐energy production facility. The separation of combustibles from noncombustibles is critical to the success of any waste‐to‐energy production facility. Air classifier technologies are relied on to aid in their separation, but often the technologies are applied to unsuitable waste flows. Costly design and operating mistakes are the rule and not the exception. Using samples of municipal solid waste, a test to predict success, both easy and economical to conduct, is considered in terms of its principles, the test methodology, and experimental results, as well as air classification comparisons. Conclusions are drawn which indicate the strengths and limitation of this method of prediction.
Development of a closed-loop artificial pancreas. (1979)

A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.
Oxidation and reduction (2007)

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Experimental workflow for developing a feed forward strategy to control biomass growth and exploit maximum specific methane productivity of <em>Methanothermobacter marburgensis</em> in a biological methane production process (BMPP) (2016)

Recently, interests for new biofuel generations allowing conversion of gaseous substrate(s) to gaseous product(s) arose for power to gas and waste to value applications. An example is biological methane production process (BMPP) with <em>Methanothermobacter marburgensis.</em> The latter, can convert carbon dioxide (CO<sub>2</sub>) and hydrogen (H<sub>2</sub>), having different origins and purities, to methane (CH<sub>4</sub>), water and biomass. However, these gas converting bioprocesses are tendentiously gas limited processes and the specific methane productivity per biomass amount (qCH<sub>4</sub>) tends to be low. Therefore, this contribution proposes a workflow for the development of a feed forward strategy to control biomass, growth (r<sub>x</sub>) and q<sub>CH4</sub> in a continuous gas limited BMPP. The proposed workflow starts with a design of experiment (DoE) to optimize media composition and search for a liquid based limitation to control selectively growth. From the DoE it came out that controlling biomass growth was possible independently of the dilution and gassing rate applied while not affecting methane evolution rates (MERs). This was done by shifting the process from a natural gas limited state to a controlled liquid limited growth. The latter allowed exploiting the maximum biocatalytic activity for methane formation of <em>Methanothermobacter marburgensis</em>. An increase of q<sub>CH4</sub> from 42 to 129 mmol<sub>CH4</sub> g<sup>−1</sup> h<sup>−1</sup> was achieved by applying a liquid limitation compare with the reference state. Finally, a verification experiment was done to verify the feeding strategy transferability to a different process configuration. This evidenced the ratio of the fed KH<sub>2</sub>PO<sub>4</sub> to r<sub>x</sub> (R(F<sub>KH2PO4</sub>/r<sub>x</sub>)) has an appropriate parameter for scaling feeds in a continuous gas limited BMPP. In the verification experiment CH<sub>4</sub> was produced in a single bioreactor step at a methane evolution rate (MER) of &nbsp;&nbsp;132 mmol<sub>CH4</sub>*L<sup>−1</sup>*h<sup>−1</sup> at a CH<sub>4</sub> purity of 93 [Vol.%].
Cooperative catalytic methoxycarbonylation of alkenes: uncovering the role of palladium complexes with hemilabile ligands (2018)

Mechanistic studies of the catalyst [Pd<sub>2</sub>(dba)<sub>3</sub>/1,1'-bis(<i>tert</i>-butyl(pyridin-2-yl)phosphanyl)ferrocene, <b>L2</b>] for olefin alkoxycarbonylation reactions are described. X-ray crystallography reveals the coordination of the pyridyl nitrogen atom in <b>L2</b> to the palladium center of the catalytic intermediates. DFT calculations on the elementary steps of the industrially relevant carbonylation of ethylene (the Lucite α-process) indicate that the protonated pyridyl moiety is formed immediately, which facilitates the formation of the active palladium hydride complex. The insertion of ethylene and CO into this intermediate leads to the corresponding palladium acyl species, which is kinetically reversible. Notably, this key species is stabilized by the hemilabile coordination of the pyridyl nitrogen atom in <b>L2</b>. The rate-determining alcoholysis of the acyl palladium complex is substantially facilitated by metal-ligand cooperation. Specifically, the deprotonation of the alcohol by the built-in base of the ligand allows a facile intramolecular nucleophilic attack on the acyl palladium species concertedly. Kinetic measurements support this mechanistic proposal and show that the rate of the carbonylation step is zero-order dependent on ethylene and CO. Comparing CH<sub>3</sub>OD and CH<sub>3</sub>OH as nucleophiles suggests the involvement of (de)protonation in the rate-determining step.
Supplementary Figure 1 from TLR9 Agonists Oppositely Modulate DNA Repair Genes in Tumor versus Immune Cells and Enhance Chemotherapy Effects (2023)

&lt;p&gt;PDF file - 1571KB, Microarray analysis of DNA repair pathway genes in lung mucosa from mice treated with CpG-ODN intranasally.&lt;/p&gt;
INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS (2016)

Introduction. Benign prostatic hyperplasia (BPHP) is one of the most common diseases in men middle-aged and elderly. In this regard, search and study of new effective and safe medicines with prostatoprotective effect is important and actual. Methods. BPHP model reproduced the intraperitoneal administration of sulpiride male rats, 40 mg / kg for 30 days. Thick Burdock extracts at a dose of 75 mg / kg and reference drug prostaplant forte, 35 mg / kg were administered intraperitoneally in a medical mode 31 to day 52 of the study. Results. The administration of thick extract of burdock roots contributed to the reliable normalization of acid phosphatase activity in serum of animals, as it is evidenced by the absence of significant differences of indicator of the treated animals from the same indicator in the groups of animals with intact control. The administration of thick extract of burdock roots contributed to a significant inhibition of LPO processes, normalization of reduced glutathione and diene conjugates in the serum levels of thiobarbituric acid active products and reduced glutathione – in the homogenate of the prostate. The effect of the indicators mentioned above thick extract of burdock roots was not significantly inferior to the effect of the drug compared with Prostaplant Forte. Thick extract of burdock leaves inferior to thick extract of burdock roots and the reference drug by normalizing influence on the activity of acid phosphatase, the level of reduced glutathione and diene conjugates in blood serum of the experimental animals.
Conclusions. The one of the most important components of the mechanism of the prostate protective action of burdock thick extracts in benign hyperplasia of the prostate gland are their anti-inflammatory and antioxidant action wich are not inferior to the reference drug Prostaplant Forte.
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs (2020)

The interest in non-surgical approaches to contraception and fertility control in female dogs has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) was evaluated in fur production animals, farmed blue fox vixens, as a model for contraception in bitches. A total of 80 vixens were divided into 4 groups, receiving orally placebo (A) or finrozole 0.5 mg/kg (B), 3.5 mg/kg (C) or 24.5 mg/kg (D) for 21 consecutive days beginning in the pre-ovulatory period of heat. Monitoring of the vixens included clinical signs of heat, measurement of vaginal electrical resistance (VER) as well as oestradiol and progesterone concentrations in plasma. The approximate relation of the start of treatment to ovulation varied from 11 days before to one day after ovulation provided that the LH peak occurred 0.5-2 days before the VER peak and ovulation was then estimated to occur 2 days after the LH peak. Seventy vixens were artificially inseminated within 8 h after a 50 Ω decline in vaginal electrical resistance was detected. Ten vixens were not inseminated. Pregnancy was confirmed by transabdominal ultrasound examination and birth of cubs was recorded. The pregnancy rates in the groups were 89.5% (A), 81.3% (B), 55.6% (C) and 52.9% (D). The average number of live born pups in the four groups was 9.4 (A), 7.0 (B), 5.8 (C), and 3.8 (D), respectively. No deleterious effects (for instance malformations) of finrozole on pups could be verified. The administration of finrozole did not have a significant effect on oestradiol parameters and VER values in vixens. Progesterone values were significantly higher in treatment groups compared with the placebo group. The results indicate that pregnancy could be avoided by finrozole provided that doses of ≥3.5 mg/kg were used and the treatment was initiated at least four days before the day of artificial insemination. This corresponds with two to six days before ovulation provided that the LH peak occurred 0.5-2 days before the VER peak and that ovulation then occurred in average 2 days after the LH peak.
Mobile product search with bag of hash bits (2011)

The advent of smart phones has provided an excellent plat- form for mobile visual search. Most of previous mobile visual search systems adopt the framework of "bag of words",in which words indicate quantized codes of visual features. In this work, we propose a novel mobile visual search system based on "bag of hash bits". Using new ideas for hash bit selection, multi-hash table generation, and hamming-distance soft scoring, we overcome the problem of bit inefficiency affecting the traditional hashing approaches, and achieve promising accuracy outperforming state of the art. The framework is also general in that general feature type can be used for generating the hash bits. Demos and experiments over a large scale product image set demonstrate the effectiveness of our approach.
Performance data of CH3NH3PbI3 inverted planar perovskite solar cells via ammonium halide additives (2019)

The data provided in this data set is the study of organic-inorganic hybrid perovskite solar cells fabricated through incorporating the small amounts of ammonium halide NH<sub>4</sub>X (X = F, Cl, Br, I) additives into a CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> (MAPbI<sub>3</sub>) perovskite solution and is published as "High-Performance CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> Inverted Planar Perovskite Solar Cells via Ammonium Halide Additives", available in Journal of Industrial and Engineering Chemistry [1]. A compact and uniform perovskite absorber layer with large perovskite crystalline grains, is realized by simply incorporating small amounts of additives into precursor solutions, and utilizing the anti-solvent engineering technique to control the nucleation and growth of perovskite crystal, turning out the enhanced device efficiency (NH<sub>4</sub>F: 14.88 ± 0.33%, NH<sub>4</sub>Cl: 16.63 ± 0.21%, NH<sub>4</sub>Br: 16.64 ± 0.35%, and NH<sub>4</sub>I: 17.28 ± 0.15%) compared to that of a reference MAPbI<sub>3</sub> device (Ref.: 12.95 ± 0.48%). In addition, this simple technique of ammonium halide addition to precursor solutions increase the device reproducibility as well as long term stability.
Adherence ofPseudomonas aeruginosato cystic fibrosis buccal epithelial cells (2017)

<b><i>Pseudomonas aeruginosa</i> cystic fibrosis buccal adherence assay</b> http://ow.ly/lPtB306VKIQ.
Partial molal volumes of tetraalkylammonium halides and assignment of individual ionic contributions (1966)

The apparent molal volumes ϕV of a series of homologous tetraalkylammonium chlorides, bromides and iodides have been measured precisely by means of a differential buoyancy technique, down to 0.01 m. The values of ϕV extrapolated to infinite dilution give partial molal volumes text-decoration:overlineV°s which are almost additive for successive homologues and enable the absolute individual partial molal volumes of the halide ions to be estimated by a new principle to an accuracy of about 0.5 ml mole–1. The concentration dependence of ϕV and text-decoration:overlineVs is anomalously large and negative, and possible origins of the effects observed are examined. In particular, the distance of closest approach, mutual salting-out associated with the large size of the ions and mutual salting-in arising from the hydrophobic character of the cations, are suggested as some of the reasons for the anomalies in the partial molal volume and activity coefficient behaviour which are exhibited by these salts.