gebhart/patrepeval huggingface dataset:
Synthesis, Oxidation Behavior, Crystallization and Structure of 2‘-Methylseleno Guanosine Containing RNAs (2006)

We have recently introduced a basic concept for the combined chemical and enzymatic preparation of site-specifically modified 2'-methylseleno RNAs which represent useful derivatives for phasing of X-ray crystallographic data during their three-dimensional structure determination. Here, we introduce the first synthesis of an appropriate guanosine phosphoramidite, which complements the thus far established set of 2'-methylseleno-modified uridine, cytidine, and adenosine building blocks for solid-phase synthesis. The novel building block was readily incorporated into RNA. Importantly, it was the 2'-methylseleno-guanosine-labeled RNA that allowed us to reveal the reversible oxidation/reduction behavior of the Se moiety and thus it represents a valuable contribution to the understanding of the action of threo-1,4-dimercapto-2,3-butanediol (DTT) required during solid-phase synthesis, deprotection, and crystallization of selenium-containing RNA. In addition, we investigated 2'-methylseleno RNA with respect to crystallization properties. Our studies revealed that the Se modification significantly increases the range of conditions leading to crystal growth. Moreover, we determined the crystal structures of model RNA helices and showed that the Se modification can affect crystal packing interactions, thus potentially expanding the possibilities for obtaining the best crystal form.
SUPPRESSION OF AVOCADO RIPENING WITH NEW PALLADIUM- PROMOTED ETHYLENE SCAVENGER (2007)

The control of ethylene in stored environments plays a key role in prolonging the life of many fresh produce types. However, there has been a paucity of research in recent years on developing novel and more effective ethylene scavenging materials. In this study a palladium (Pd)-promoted powdered material that has significant ethylene adsorption capacity (4162 µl g-1 material) at 20°C and approx. 100 % RH was identified and was shown to be far superior to KMnO4 when used in low amounts and in conditions of high relative humidity (RH). Initial screening was carried out in a plug flow reactor with 200 µl l-1 ethylene, 10 % (v/v) O2 balanced with He at approx. 100 % RH. Further work demonstrated that the Pd-promoted material at 0.03 g l-1 effectively scavenged both exogenously administered (100 µl l-1) and/or endogenously produced ethylene by avocado, respectively, to sub-µl l-1 concentrations within a 24h period. Optimum ethylene adsorption capacity was calculated as approx. 10000 µl g-1. Accordingly, corresponding inhibition of ethylene-induced ripening was observed. When removed, Pd-material did not disrupt subsequent ripening. The results from this study demonstrate that Pd-promoted material has commercial potential.
Stochastic nonlinear electrical characteristics of graphene (2013)

A stochastic nonlinear electrical characteristic of graphene is reported. Abrupt current changes are observed from voltage sweeps between the source and drain with an on/off ratio up to 103. It is found that graphene channel experiences the topological change. Active radicals in an uneven graphene channel cause local changes of electrostatic potential. Simulation results based on the self-trapped electron and hole mechanism account well for the experimental data. Our findings illustrate an important issue of reliable electron transports and help for the understanding of transport properties in graphene devices.
ChemInform Abstract: Phosphoinositides and Their Stimulated Breakdown (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Semiparametric Optimal Estimation With Nonignorable Nonresponse Data (2016)

When the response mechanism is believed to be not missing at random (NMAR), a valid analysis requires stronger assumptions on the response mechanism than standard statistical methods would otherwise require. Semiparametric estimators have been developed under the model assumptions on the response mechanism. In this paper, a new statistical test is proposed to guarantee model identifiability without using any instrumental variable. Furthermore, we develop optimal semiparametric estimation for parameters such as the population mean. Specifically, we propose two semiparametric optimal estimators that do not require any model assumptions other than the response mechanism. Asymptotic properties of the proposed estimators are discussed. An extensive simulation study is presented to compare with some existing methods. We present an application of our method using Korean Labor and Income Panel Survey data.
Estimation of displacements from two 3D frames obtained from stereo (1991)

A method for estimating 3D displacements from two stereo frames is presented. It is based on the hypothesize-and-verify paradigm used to match 3D line segments between the two frames. In order to reduce the complexity of the method, an assumption is made that objects are rigid. The formulate a set of complete rigidity constraints for 3D line segments and integrate the uncertainty of measurements in this formation. The hypothesize-and-verify stages of the method use an extended Kalman filter to produce estimates of the displacements and of their uncertainty. The algorithm is shown to work on indoor and natural scenes. It is also shown to be easily extended to the case in which several mobile objects are present. The method is quite robust, fast, and has been thoroughly tested on hundreds of real stereo frames. >
Video-Realistic Inner Mouth Reanimation (2013)

We propose a novel post-effect method that can make an existing speech animation video-realistic by generating an inner mouth appearance that is tailored to the speaker. The automatic generation of photorealistic inner mouth appearances requires only simple inputs and small databases and is not restricted by video lighting. The approach is also applicable for creature speech animation with human voices. Our system uses two key algorithms; one of the algorithms models the inner mouth appearances based on physical assumptions, and the other algorithm synthesizes the inner mouth images with care taken to maintain time continuity and luminance gradients.
Supplementary Data from A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors (2023)

&lt;p&gt;Tables S1 to S9 Figures S1 to S6&lt;/p&gt;
A multilevel transmission technique based on stacked optical binary signals for upgrading TDM-PON systems (2008)

We propose a multilevel transmission technique using stacked optical binary signals without any loss budget reduction when receiving multilevel signals. The principle is described and the validity of the technique is verified by numerical calculation.
Harmonisation of full blood count reports, recommendations of the French-speaking cellular haematology group (GFHC) (2016)

The recommendations can help biologists who are currently undergoing the process of accreditation.
Antenna Element Index Modulation for Frequency Diverse Array (2019)

In this paper, we propose a new architecture and provide performance analysis for frequency diverse array (FDA) Radar combined with the index modulation (IM) techniques. Here, the IM concept is applied upon frequency offsets in an FDA. Information is transmitted by a dynamically selected subset of antenna element indices applying predefined carrier frequency offsets, which generate different radiation patterns. It is shown that this enables the capability for simultaneous wireless communication and FDA Radar that has the range-angle coupling issue resolved.
Regulations and market trends in lead‐free and halogen‐free electronics (2007)

Purpose This paper seeks to investigate the electronics industry's reaction to environmental regulations specifically in terms of lead‐free solders and halogen‐free flame‐retardants (FRs). Design/methodology/approach This work achieves its objective by discussing the various international environmental regulations pertaining to electronics manufacturing and relating the industry reactions to those regulations. It also provides the market trends related to lead‐ and halogen‐free products. The electronics industry is pursuing lead‐free solders and halogen‐free FRs, in part due to regulations. However, the paper includes examples of how the industry is successful in implementing environmentally friendly changes. Findings The authors compared regulations from Japan, the European Union, the USA, and China. While the regulations themselves vary in scope, industry actions to find alternatives do have common purposes. Electronics manufacturers recognize that environmentally motivated changes are beneficial in terms of waste minimization. Research limitations/implications Electronics manufacturers that are interested in green design will benefit from understanding present regulations. They will also benefit from the included examples of product and process improvement for the purpose of environmental compatibility. Originality/value This paper derives its perspective from a similar review of literature and company findings that the authors completed in 2006. As refinement of the regulations has continued, the electronics industry has developed improvements in basic materials and processes.
ChemInform Abstract: SYNTHESIS OF NEW PHOSPHOLENES AND PHOSPHOLES WITH FUNCTIONAL SUBSTITUENTS ON THE PHOSPHORUS (1976)

Abstract Die Reaktion von (I) mit den funktionellen Halogeniden (II) liefert durch Quatemisierung Addukte, die formal den Dien‐Dihalogenphosphin‐McConnack‐ Cycloaddukten vergleichbar sind.
Flour of corn for dye removal from pulp and paper effluents (2008)

International audience
Dehydrogenation of Alcohols by Lithium Metal-Ethylenediamine System (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehydrogenation of Alcohols by Lithium Metal-Ethylenediamine SystemShelbert Smith, Richard Thompson, and E. O. WoolfolkCite this: J. Org. Chem. 1962, 27, 7, 2662–2663Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/jo01054a521https://doi.org/10.1021/jo01054a521research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A CUTANEOUS ERUPTION WITH EPIDERMAL PUSTULES IN PATIENTS RECEIVING BONE MARROW TRANSPLANTATION. (1998)

s From The 19Th Colloquium Of The International Society Of Dermatopathology (Isd), November 5-7, 1998, Madrid, Spain
Older and Younger Adults in Pain Management Programs in the United States: Differences and Similarities (2006)

Older adults with chronic pain differ in a number of important domains from younger adults with chronic pain: overall the former present with greater physical, and less psychosocial impairment.
Conversion efficiency improvement of terahertz wave generation laterally emitted by a ridge-type periodically poled lithium niobate (2022)

We demonstrate terahertz (THz) wave generation by wavelength conversion in a ridge-type/bulk periodically poled lithium niobate (RT-/bulk-PPLN) under almost the same experimental conditions. When using the RT-PPLN, the ridge structure works as a slab waveguide for the incident pump beam (wavelength: ∼1 μm), and the generated THz wave (∼200 μm) was emitted uniformly from the entire side surface of the crystal. The RT-PPLN has a much higher conversion efficiency from the pumping beam to the THz wave than the bulk-PPLN, and the ratio improved several ten times compared with those of previous studies.
Biomechanical Analysis of Rotational Motions After Disc Arthroplasty (2006)

The neutral zone of the intact cervical spine was restored even using an unconstrained cervical TDR. The greater inherent rotational constraints of the cervical spine make it more amenable to stable multilevel arthroplasty compared with the lumbar spine.
Atom Probe Field Ion Microscopy of Titanium Aluminides (1998)

Abstract Titanium aluminides have a number of potential high temperature applications due to their good elevated-temperature mechanical properties, low density, and good creep and oxidation resistance. However, fabrication of commercial components of these materials has been impeded by their poor mechanical properties at ambient temperatures. Significant efforts with various degrees of success have been made to improve the mechanical properties of these TiAl alloys by doping them with a variety of different elements including B, C, Cr, Er, Fe, Mn, Mo, Ni, Nb, P, Si, Ta, V and W. One of the optimum analytical tools for investigating the effects of these additions on the microstructure is the atom probe field ion microscope. However, relatively few studies of titanium aluminides, compared to some other intermetallic compounds, have performed by atom probe field ion microscopy. This lack of attention can be attributed to the brittle nature of the material, in-situ transformations that occur during the field ion microscopy and preferential evaporation problems that were encountered in some of the early studies.
Specific polypeptide markers in chronic B cell malignancies detected by two‐dimensional gel electrophoresis (1992)

Two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) analysis of silver stained polypeptides was used to discriminate the cell protein profiles in chronic B cell malignancies. We identified 5 distinct polypeptides (H1 to H5) present in hairy cell leukemia (HCL) (14 cases) and absent in most chronic lymphocytic leukemia (CLL) and normal B lymphocytes. Two polypeptides, H2 and H5, were absolutely specific of HCL. The 2-D PAGE profiles found in 3 splenic lymphoma with villous lymphocytes (SLVL) and 2 HCL variants (HCL-V) were similar to HCL with a unique additional peptide present in 3/3 SLVL and 1/2 HCL-V. When HCL and SLVL were assessed for the CLL stage-specific 2-D PAGE patterns, HCL was related to stage A/B while SLVL was related to stage C. In conclusion, 2-D PAGE analysis of the molecular pattern of B lymphocytes provides a new means to recognize the leukemic origin of the sample and distinguish HCL from CLL and SLVL.
Fluidic self-alignment applied to a micro-fluidic system (2006)

A technique for the self-alignment of components is applied to the assembly of a passive micro-valve which is to be used for safety purposes in a miniature fuel cell. The technique uses the capillary forces originating in the interactions of HMDS (Hexadimethyldisilazane) and the faces of the components to achieve their passive alignment. HMDS is chosen because it is a volatile, low surface tension and inert liquid. The originality of this method is that the liquid area is defined by the edges of the components. Compared to a traditional pick-and-place technique, it leads to a leakage rate more than five times smaller.
Electronic properties of single-crystal diamonds heavily doped with boron (2007)

Single-crystal diamonds with characteristic sizes of 2–7 mm doped with boron in the concentration range 1019–1020 cm−3 have been grown by the temperature gradient method at high static pressures. The temperature dependence of the resistance R of the synthesized single crystals has been measured in the range 0.5 K < T < 297 K. An activated dependence R(T) with an activation energy of about 50 meV is observed in the range from room temperature to T ≈ 200 K. At temperatures below approximately 50 K, the temperature dependence of the conductivity for heavily doped crystals is proportional to T 1/2, which is characteristic of degenerate semiconductors with a high number of defects.
Circadian phase asessment by ambulatory monitoring in humans: Correlation with dim light melatonin onset (2013)

The increased prevalence of circadian disruptions due to abnormal coupling between internal and external time makes the detection of circadian phase in humans by ambulatory recordings a compelling need. Here, we propose an accurate practical procedure to estimate circadian phase with the least possible burden for the subject, that is, without the restraints of a constant routine protocol or laboratory techniques such as melatonin quantification, both of which are standard procedures. In this validation study, subjects (N = 13) wore ambulatory monitoring devices, kept daily sleep diaries and went about their daily routine for 10 days. The devices measured skin temperature at wrist level (WT), motor activity and body position on the arm, and light exposure by means of a sensor placed on the chest. Dim light melatonin onset (DLMO) was used to compare and evaluate the accuracy of the ambulatory variables in assessing circadian phase. An evening increase in WT: WTOnset (WTOn) and "WT increase onset" (WTiO) was found to anticipate the evening increase in melatonin, while decreases in motor activity (Activity Offset or AcOff), body position (Position Offset (POff)), integrative TAP (a combination of WT, activity and body position) (TAPOffset or TAPOff) and an increase in declared sleep propensity were phase delayed with respect to DLMO. The phase markers obtained from subjective sleep (R = 0.811), WT (R = 0.756) and the composite variable TAP (R = 0.720) were highly and significantly correlated with DLMO. The findings strongly support a new method to calculate circadian phase based on WT (WTiO) that accurately predicts and shows a temporal association with DLMO. WTiO is especially recommended due to its simplicity and applicability to clinical use under conditions where knowing endogenous circadian phase is important, such as in cancer chronotherapy and light therapy.
Observation of 2D Semiconductor Dark Exciton Lifetime Using Two-photon Ultrafast Spectroscopy (2018)

Using two-photon pump-probe on MoS2 we excite directly dark-excitons and probe bright-excitonic population with femtosecond resolution. Non-monotonic density changes in bright-exciton population determine directly dark-exciton lifetime in monolayers.
A novel COL1A1 mutation in a family with osteogenesis imperfecta associated with phenotypic variabilities (2017)

Osteogenesis imperfecta (OI) is a heterogeneous disorder that is characterized by bone fragility and systemic complications, and is mainly caused by gene mutations in <i>COL1A1</i> or <i>COL1A2</i>. A novel <i>COL1A1</i> splicing mutation, c.750+2T>A, was identified in a Japanese OI family. Only the proband in this family showed various complications, such as heart valve diseases and severe scoliosis. The clinical heterogeneity in the family is discussed in this study.
Individual Contributions for Collective Goods (1975)

There is a growing controversy as to what behavior is to be expected of individuals regarding contributions for the supply of collective goods. This paper attempts to settle some of the controversy. It attempts to do so not by showing that one of the positions taken is correct and the others wrong, but by showing that the various authors in question reach different conclusions about individual behavior in situations involving the potential supply of collective goods because they make different assumptions regarding the nature of the goods and the nature of the situations in which the individuals find themselves. The different conclusions are reconciled by a careful examination of the assumptions of the authors. Specific variables are identified which account for the differences in the models and a set of dimensions along which collective goods situations can vary is presented.
Solid waste spent catalyst recover from North Atlantic Refinery’s petrochemical plant in Come by Chance, NL (2015)

A hydrometallurgical process has been developed for metal recovery from spent HPCs. After analysing our catalyst, preliminary experiments showed that aqua regia is the most effective leaching agent to dissolve metals from our spent catalyst samples. Two amine-based extractants (Alamine308 &amp; Alamine336), and one quaternary ammonium salt (Aliquat336) were diluted in toluene and were tested for cobalt, nickel, and molybdenum extraction from leached catalysts in aqua regia. A central composite design (CCD) was employed for our experimental&#13;\ndesign, and the best extractant was selected based on the ICP analysis on the efficiency, concentration requirement (cost-effectiveness), and required contact time for optimum metal removal. The effects of significant parameters on the extraction processes have been measured, and statistical models were developed using Design Expert software. ANOVA results were also studied to measure the accuracy and significance of the fitted models. Optimization of each solvent extraction process was completed and optimum points were determined for maximum metal removal from spent HPCs.
Machine learning-assisted medium optimization revealed the discriminated strategies for improved production of the foreign and native metabolites (2023)

The composition of medium components is crucial for achieving the best performance of synthetic construction in genetically engineered cells. Which and how medium components determine the performance, e.g., productivity, remain poorly investigated. To address the questions, a comparative survey with two genetically engineered <i>Escherichia coli</i> strains was performed. As a case study, the strains carried the synthetic pathways for producing the aromatic compounds of 4-aminophenylalanine (4APhe) or tyrosine (Tyr), common in the upstream but differentiated in the downstream metabolism. Bacterial growth and compound production were examined in hundreds of medium combinations that comprised 48 pure chemicals. The resultant data sets linking the medium composition to bacterial growth and production were subjected to machine learning for improved production. Intriguingly, the primary medium components determining the production of 4PheA and Tyr were differentiated, which were the initial resource (glucose) of the synthetic pathway and the inducer (IPTG) of the synthetic construction, respectively. Fine-tuning of the primary component significantly increased the yields of 4APhe and Tyr, indicating that a single component could be crucial for the performance of synthetic construction. Transcriptome analysis observed the local and global changes in gene expression for improved production of 4APhe and Tyr, respectively, revealing divergent metabolic strategies for producing the foreign and native metabolites. The study demonstrated that ML-assisted medium optimization could provide a novel point of view on how to make the synthetic construction meet the designed working principle and achieve the expected biological function.