gebhart/patrepeval huggingface dataset:
Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study (2023)

Laparoscopic surgery was not a risk factor affecting the oncologic prognosis of adenosquamous carcinoma of the cervix based on either FIGO 2009 or 2018 staging of stage IA2-IIA2. In addition, LRH may be considered for patients with early-stage cervical adenosquamous carcinoma.
Oscillations and running waves observed in sunspots (2001)

We continue our study of waves and oscillations observed in sunspots using an improved method for enhancing the waves, giving the opportunity to identify them and determine their properties in far Hα wings. We found that the running penumbral waves are observable at least up to the formation height of the H Å line, but not in the H Å or the Å. We found a time lag between the waves in the blue and the red wing of the Hα line corresponding to a phase shift of 180°, that indicates a pure Doppler shift of the line. There is a lag in the propagation of the waves seen at Hα center and at Hα wings. Also there is a lag in the variation of the umbral oscillations as they are observed from lower to higher atmospheric layers. The correlation between umbral oscillations at various atmospheric heights and running penumbral waves strongly indicates that the latter are excited by photospheric umbral oscillations and not the chromospheric ones. We found a new category of photospheric waves that originate at approximately 0.7 of the distance between the umbra and the penumbra boundary and propagate beyond the outer penumbra boundary with a velocity of the order of 3-4 km s-1. Further, we found 3 min penumbral oscillations apparent in the inner penumbra at lower chromospheric layers (far Hα wings).
Filgotinib, a novel JAK1-preferential inhibitor for the treatment of rheumatoid arthritis: An overview from clinical trials (2021)

In the treatment of rheumatoid arthritis (RA), Janus kinase inhibitors (jakinibs) represent an emerging class of targeted therapies in addition to biologics. The number of jakinibs has been growing and as of 2020, filgotinib was the latest jakinib to enter the international market for treating RA. Filgotinib has demonstrated preferential inhibition of JAK1-dependent cytokine signaling in in vitro assays. It has been evaluated in the DARWIN (phase 2) and FINCH (phase 3) series of clinical studies for treating patients with moderately-to-severely active RA. Filgotinib received regulatory approval in Japan and Europe in September 2020, while in August 2020 the United States Food and Drug Administration requested additional data from two ongoing clinical studies assessing the potential impact of filgotinib on sperm parameters. This article will review the pharmacological properties, efficacy, and safety of filgotinib as demonstrated in clinical studies. Expert opinion will be provided on jakinibs for RA treatment from the viewpoints of basic research and clinical practice.
Cobalt-Catalyzed (E)-Selective anti-Markovnikov Hydrosilylation of Terminal Alkynes (2018)

We report a regioselective and stereoselective hydrosilylation of terminal alkynes with catalysts generated from bench-stable Co(acac)2 and bisphoshpine ligands. The cobalt catalyst precursors are activated by the reaction with hydrosilanes, and air-sensitive activators, such as Grignard reagents or NaBHEt3, are not required for catalyst activation. A wide range of aromatic and aliphatic terminal alkynes underwent this cobalt-catalyzed hydrosilylation, affording the corresponding (E)-vinylsilanes in high yields with high regioselectivity and stereoselectivity. These reactions show good functional group compatibility and can be readily scaled up to gram-scales without using a drybox. Deuterium-labeling experiments suggest a cis-addition of hydrosilanes to alkynes.
Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip (2022)

Functional differentiation of pancreatic like tissue from human induced pluripotent stem cells is one of the emerging strategies to achieve an <i>in vitro</i> pancreas model. Here, we propose a protocol to cultivate hiPSC-derived β-like-cells coupling spheroids and microfluidic technologies to improve the pancreatic lineage maturation. The protocol led to the development of spheroids producing the C-peptide and containing cells positive to insulin and glucagon. In order to further characterize the cellular and molecular profiles, we performed full transcriptomics and metabolomics analysis. The omics analysis confirmed the activation of key transcription factors together with the upregulation of genes and the presence of metabolites involved in functional pancreatic tissue development, extracellular matrix remodeling, lipid and fatty acid metabolism, and endocrine hormone signaling. When compared to static 3D honeycomb cultures, dynamic 3D biochip cultures contributed to increase specifically the activity of the HIF transcription factor, to activate the calcium activated cation channels, to enrich the glucagon and insulin pathways and glycolysis/gluconeogenesis, and to increase the secretion of serotonin, glycerol and glycerol-3-phosphate at the metabolic levels.
Author Correction: Water molecular structure underpins extreme desiccation tolerance of the resurrection plant Haberlea rhodopensis (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
ChemInform Abstract: Advances in the Chemistry of Sulfilimines (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Band edge modulated conjugated polymers for oxidation prevention (2012)

The impact of electron transfer (ET) from a series of band edge modulated polymers to atmospheric oxygen is examined in connection with substrate oxidation prevention. Polymers with the highest occupied molecular orbital (HOMO) energy level below and above the oxygen energy level were tested and the former showed better efficiency. Furthermore, the oxidation prevention efficiency of a polymer with lower HOMO increased by two orders of magnitude, when the pores on the film were filled with spherical molecules, [6,6]-phenyl-C61-butyric acid methyl ester. We found that the polymer surface hydrophobicity has little or no influence on oxidation prevention. It is interesting to note that a polymer with a hole mobility of 8 × 10(-10) cm(2) V(-1) s(-1) showed a two-fold increase in oxidation prevention efficiency compared to a polymer with a hole mobility of 6 × 10(-5) cm(2) V(-1) s(-1). Over all, from the concerted approach, we conclude that a polymer devoid of pores with the HOMO energy level below oxygen and low charge carrier mobility is a suitable candidate for prevention of substrate oxidation/corrosion.
Role Of Surface Negative Charge In Platelet Aggregation (1981)

The relationship between aggregability and electrophoretic mobility (EPM) was studied to clarify the role of surface negative charge in platelet function. 1. Human platelets were washed 3 times with Phillip’s buffer (pH 7.4), resuspended to 107 platelets/ml in modified Zeiller and Hannig’s buffer with 1 mM EDTA and incubated with various concentrations of ADP, adrenaline, thrombin and ristocetin at 37°C for 3 min. Without further washing, mean EPM of about 700 platelets was determined by the automatic Laser Zee System 3000 with good reproducibility with less than 1 % variation coefficient for 5 measurements. In all experiments, aggregating agents were dissolved in physiologic saline to obtain the same solution conductance both in test and control platelet suspensions to which saline alone was added. Neither 1-100 uM ADP nor 5-500 μM adrenaline had any effect on platelet EPM. Thrombin decreased EPM with dose response relation with -1.692±0.014 μm/sec/V/cm without thrombin, -1.580±0.084 with o725 , -1.578±0.001 with 1.0, -1.454±0.018 with 2.0 and -1.289±0.004 with 5.0 U/ml of thrombin. Ristocetin had decreasing effect on EPM at 0.2 mg/ml or less. After addition of above aggregating agents, the washed platelets did not aggregate under phase contrast microscopy. 2. EPM of washed platelets were compared with aggregability in the PRP collected from 33 clinical cases with various degrees of aggregation. There was no correlation between EPM and secondary and maximum aggregation induced by any of these four agents. However, intensity of primary aggregation by adrenaline correlated with EPM (r= 0.485, P&lt;0.01). The same tendency was observed in primary aggregation by ADP. 3. Treatment of washed rabbit platelets with increasing doses of neuraminidase resulted in increasing aggregation by ADP and collagen associated with decrease in EPM. These findings suggested that platelet surface negative charge may be regulatory role in initiation of platelet activation.
Device-level Transient Cooling of β-Ga2O3 MOSFETs (2022)

β-phase gallium oxide (β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> ) has garnered considerable attention due to its large critical electric field strength and the availability of low cost/high quality melt-grown substrates, both of which are advantages over silicon carbide (SiC) and gallium nitride (GaN) in terms of the development radio frequency (RF) and power switching devices. However, because of the low thermal conductivity of β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> , thermal management strategies at the device-level are required to accomplish the targeted high power operation. Recent package- and system-level thermal management studies have shown that design solutions based on steady-state operation could lead to ineffective cooling performance under transient thermal loading conditions, and result in an overdesigned cooling system. For these reasons, we performed a comparative study of the thermal dynamics of β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> and GaN based transistor devices, which sheds light on the design of device-level transient cooling solutions for β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> metal-oxide-semiconductor field-effect transistors (MOSFETs). Results show that replacing the host β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> substrate with a high thermal conductivity material, similar to device-level thermal management solutions established for GaN devices, is effective in terms of heat extraction from the device active region under direct current (DC) operating conditions, but not under high frequency power dissipating conditions beyond the ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> kHz range. In order to cool lateral β-Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> MOSFETs under transient pulse-powered conditions, additional topside heat extraction via a high thermal conductivity passivation overlayer is necessary.
Ongoing risk of bladder cancer among former workers at the last benzidine manufacturing facility in the USA (2021)

Incidence and mortality due to bladder cancer increased among workers exposed to benzidine but not among workers exposed only to dichlorobenzidine. The risk of incidence and death from bladder cancer remain elevated more than 20 years after last exposure to benzidine in those who worked <u>></u>5 years.
Pitch Control in Thermomechanical Pulping and Papermaking by Enzymatic Treatments (2005)

Colloidal wood resin can become unstable in pulp and papermaking processes forming pitch deposits that affect both runnability and product quality. Enzymatic treatments can degrade triglycerides to fatty acids, which may affect the deposition tendency of the resin. In this paper, the effects of enzymatic treatment of wood resin in TMP were studied using four modified lipases. At 60 C the unmodified Resinase hydrolysed 90% of the triglycerides and reduced the amount of deposit, but the efficiency decreased at higher temperatures. With the most thermostable modified Resinase it was possible to hydrolyse 72% of the triglycerides even at 85 C, which is very important for industrial applications. Despite the efficient enzymatic hydrolysis of the triglycerides, the deposition tendency of the colloidal wood resin was not always reduced.
Steam turbine materials and corrosion (2007)

Ultra-supercritical (USC) power plants offer the promise of higher efficiencies and lower emissions. Current goals of the U.S. Department of Energy’s Advanced Power Systems Initiatives include coal generation at 60 % efficiency, which would require steam temperatures of up to 760 °C. In prior years this project examined the steamside oxidation of alloys for use in high- and intermediate-pressure USC turbines. This steamside oxidation research is continuing and progress is presented, with emphasis on chromia evaporation.
Extrasolar Planet Transit Light Curves and a Method to Select the Best Planet Candidates for Mass Follow-up (2002)

A unique analytical solution of planet and star parameters can be derived from an extrasolar planet transit light curve under a number of assumptions. This analytical solution can be used to choose the best planet transit candidates for radial velocity follow-up measurements, with or without a known spectral type. In practice, high photometric precision (&lt; 0.005 mag) and high time sampling (&lt; 5 minutes) are needed for this method. See Seager &amp; Mallen-Ornelas (2002) for full details.
Education and Apprenticeship (2013)

This chapter examines the religious, cultural, and occupational aspects of upbringing, broadly construed, in seventeenth-century Wilno. One of the terms for “upbringing” generally used at the time, wychowanie (a verbal substantive from the infinitive wychowac´), also included—perhaps even implied for the majority—first and foremost the simplest material aspects of care for minors: food, clothing, shelter. Here the chapter looks at spiritual, intellectual, and practical components of providing and acquiring training in the faith and the tools of a profession and/or trade. The chapter’s focus is largely on the role of confessional allegiances and identities in forming interpersonal associations in the context of providing and acquiring an education in the broader sense of the term.
ChemInform Abstract: Meisenheimer Rearrangement of Azetopyridoindoles. Part 4. Ring Expansion of 2‐Vinyl‐1,2,4,5,10,10b‐hexahydroazeto(1′,2′:1,2)pyrido(3, 4‐b)indole N‐Oxides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The structure of the gene for cecropin B, an antibacterial immune protein from Hyalophora cecropia (1988)

Pupae of the moth Hyalophora cecropia respond to an injection of live bacteria by the production of a potent antibacterial activity. The broad-spectrum property of this activity is due chiefly to two small proteins, cecropins A and B. Sequences of the proteins showed them to be homologous and to contain 37 and 35 amino acid residues respectively. The subsequent isolation of two cDNA clones for cecropin B showed that this protein is made as a prepro molecule composed of 62 amino acid residues. We have now prepared a genomic bank and studied four genomic clones for cecropin B. The coding regions were found in two neighbouring BglII fragments, one 0.79 kb and another varying in size from 3.1 kb to 4.9 kb for different clones. One transcriptional unit for preprocecropin B was sequenced and found to be 1035 bp long with a single intron, 514 bp in size. A conserved, insect specific cap site, ATCATTC, was identified by S1 mapping and primer extension experiments. Indications were found for the presence of multigene families and multicopy genes.
Catalytic Conversion of Furfural into a 2,5‐Furandicarboxylic Acid‐Based Polyester with Total Carbon Utilization (2012)

One divided into two combined into one: The catalytic conversion of furfural into a 2,5-furandicarboxylic acid-based polyester, linked by the disproportionation of furoate to furan and 2,5-furandicarboxylate, is reported. In this manner, all carbons are utilized, demonstrating the success of combining a platform molecule from C(5) sugars (furfural) to one from C(6) sugars (2,5-FDCA).
Fully automated proteomic detection of cervical dysplasia. (2002)

Both EGFR and TfR assays detected HSIL with very high accuracy (100% and 96.3%, respectively). Specificity of the TfR assay was slightly higher (81.3%) than that of the EGFR assay (73.3%). HPV E5-induced disruption of intracellular endosomal acidification and its effects upon both EGFR and TfR may provide the specific mechanistic connection between overexpression of these receptor proteins, and HPV in fection and integration. EGFR and especially TfR show great promise as biomarkers in a highly sensitive and specific, fully automated assay for the early detection of cervical dysplasia.
A non-parametric approach to measuring the K−π+ amplitudes in D+→K−K+π+ decay (2007)

Using a large sample of D+→K−K+π+ decays collected by the FOCUS photoproduction experiment at Fermilab, we present the first non-parametric analysis of the K−π+ amplitudes in D+→K−K+π+ decay. The technique is similar to the technique used for our non-parametric measurements of the D+→K¯∗0e+ν form factors. Although these results are in rough agreement with those of E687, we observe a wider S-wave contribution for the K¯0∗0(1430) contribution than the PDG [W.-M. Yao, et al., J. Phys. G 33 (2006) 1], world average mass and width. We have some weaker evidence for the existence of a new, D-wave component at low values of the K−π+ mass.
Organic Zeolites (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
27.3 EM and Power SCA-Resilient AES-256 in 65nm CMOS Through >350× Current-Domain Signature Attenuation (2020)

Computationally-secure cryptographic algorithms when implemented on physical platforms leak critical physical signals correlated with the secret key in the form of power consumption and electromagnetic (EM) emanations. This can be exploited by an adversary, leading to side-channel attacks (SCA) that can recover the secret key. Circuit-level on-chip countermeasures include a switched-capacitor current equalizer [1], charge-recovery logic [2], an integrated voltage regulator (IVR) [3], and an all-digital low-dropout (LDO) regulator [4], which suffer from performance degradation, high power/area overheads because of large embedded passives, as well as EM leakage from large metal-insulator-metal (MIM) capacitor top plates. Alternatively, simulations of shunt LDO-based regulators have been shown to be effective for power SCA resistance [5]. Noting that the correlated current is the source of both power (at supply pin) and EM leakage (radiation throughout current path), this work embraces current-domain `signature attenuation' (CDSA) as a low-overhead generic countermeasure against both EM and power side-channel attacks to achieve the highest minimum traces to disclosure (MTD reported to date.
<title>High-performance analysis of single interphase cells with custom DNA probes spanning translocation break points</title> (1999)

The chromatin organization of interphase cell nuclei, albeit an object of intense investigation, is only poorly understood. In the past, this has hampered the cytogenetic analysis of tissues derived from specimens where only few cells were actively proliferating or a significant number of metaphase cells could be obtained by induction of growth. Typical examples of such hard to analyze cell systems are solid tumors, germ cells and, to a certain extent, fetal cells such as amniocytes, blastomeres or cytotrophoblasts. Balanced reciprocal translocations that do not disrupt essential genes and thus do not led to disease symptoms exit in less than one percent of the general population. Since the presence of translocations interferes with homologue pairing in meiosis, many of these individuals experience problems in their reproduction, such as reduced fertility, infertility or a history of spontaneous abortions. The majority of translocation carriers enrolled in our in vitro fertilization (IVF) programs carry simple translocations involving only two autosomes. While most translocations are relatively easy to spot in metaphase cells, the majority of cells biopsied from embryos produced by IVF are in interphase and thus unsuitable for analysis by chromosome banding or FISH-painting. We therefore set out to analyze single interphase cells for presence or absence of specific translocations. Our assay, based on fluorescence in situ hybridization (FISH) of breakpoint-spanning DNA probes, detects translocations in interphase by visual microscopic inspection of hybridization domains. Probes are prepared so that they span a breakpoint and cover several hundred kb of DNA adjacent to the breakpoint. On normal chromosomes, such probes label a contiguous stretch of DNA and produce a single hybridization domain per chromosome in interphase cells. The translocation disrupts the hybridization domain and the resulting two fragments appear as physically separated hybridization domains in the nucleus. To facilitate the detection, DNA probes for breakpoints on different chromosomes are labeled in different colors, so the translocation event can be detected as a fusion of red and green hybridization domains. We applied this scheme successfully for the analysis of somatic and germ cells from more than 20 translocation patients, each with individual breakpoints, and provide summaries of our experience as well as strategies, cost and time frames to prepare case-specific translocation probes.
Selective abstraction of AI system activity (1984)

The need for presenting useful descriptions of problem solving activities has grown with the size and complexity of contemporary AI systems. Simply tracing and explaining the activities that led to a solution is no longer satisfactory. We describe a domain-independent approach for selectively abstracting the chronological history of problem solving activity (a system trace) based upon user-supplied abstraction goals. An important characteristic of our approach is that, given different abstraction goals, abstracted traces with significantly different emphases can be generated from the same original trace. Although we are not concerned here with the generation of an explanation from the abstracted trace, this approach is a useful step towards such an explanation facility. I. Introduction: The Problem