gebhart/patrepeval huggingface dataset:
Trait related sensorimotor deficits in people who stutter: An EEG investigation of μ rhythm dynamics during spontaneous fluency (2018)

Stuttering is associated with compromised sensorimotor control (i.e., internal modeling) across the dorsal stream and oscillations of EEG mu (<i>μ</i>) rhythms have been proposed as reliable indices of anterior dorsal stream processing. The purpose of this study was to compare <i>μ</i> rhythm oscillatory activity between (PWS) and matched typically fluent speakers (TFS) during spontaneously fluent overt and covert speech production tasks. Independent component analysis identified bilateral <i>μ</i> components from 24/27 PWS and matched TFS that localized over premotor cortex. Time-frequency analysis of the left hemisphere <i>μ</i> clusters demonstrated significantly reduced <i>μ-α</i> and <i>μ-β</i> ERD (<i>p</i><sub>CLUSTER</sub> < 0.05) in PWS across the time course of overt and covert speech production, while no group differences were found in the right hemisphere in any condition. Results were interpreted through the framework of State Feedback Control. They suggest that weak forward modeling and evaluation of sensory feedback across the time course of speech production characterizes the trait related sensorimotor impairment in PWS. This weakness is proposed to represent an underlying sensorimotor instability that may predispose the speech of PWS to breakdown.
P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. (1989)

We have utilized c-abl antibodies and an in vitro kinase assay to identify the protein products of the c-abl gene in mouse testis. Although the testis contains high levels of a unique c-abl mRNA, along with lower amounts of two c-abl mRNAs common to somatic cells, we detected only a single polypeptide of approximately 150 kd, indistinguishable by our methods from P150c-abl observed in murine tissues and cell lines. P150c-abl was also detected in enriched populations of germ cells, including late stage spermatids which contain the highest levels of the novel c-abl transcript. In mature testis, and specifically in late spermatids, P150c-abl co-precipitated with phosphoproteins of approximately 74 kd which were labeled during the in vitro kinase assay. These proteins were phosphorylated predominantly on serine and their phosphopeptide maps differed from that of P150c-abl. The P74 phosphoproteins were not found in association with P150c-abl in germ cells at earlier developmental stages, nor in other tissues or cell lines examined.
Graphonomy: Universal Human Parsing via Graph Transfer Learning (2019)

Prior highly-tuned human parsing models tend to fit towards each dataset in a specific domain or with discrepant label granularity, and can hardly be adapted to other human parsing tasks without extensive re-training. In this paper, we aim to learn a single universal human parsing model that can tackle all kinds of human parsing needs by unifying label annotations from different domains or at various levels of granularity. This poses many fundamental learning challenges, e.g. discovering underlying semantic structures among different label granularity, performing proper transfer learning across different image domains, and identifying and utilizing label redundancies across related tasks. To address these challenges, we propose a new universal human parsing agent, named “Graphonomy”, which incorporates hierarchical graph transfer learning upon the conventional parsing network to encode the underlying label semantic structures and propagate relevant semantic information. In particular, Graphonomy first learns and propagates compact high-level graph representation among the labels within one dataset via Intra-Graph Reasoning, and then transfers semantic information across multiple datasets via Inter-Graph Transfer. Various graph transfer dependencies (e.g., similarity, linguistic knowledge) between different datasets are analyzed and encoded to enhance graph transfer capability. By distilling universal semantic graph representation to each specific task, Graphonomy is able to predict all levels ofparsing labels in one system without piling up the complexity. Experimental results show Graphonomy effectively achieves the state-of-the-art results on three human parsing benchmarks as well as advantageous universal human parsing performance.
Mapping Discovery in P2P databases: a query-based approach (2009)

In this paper, we investigate a query-based approach to mapping discovery in peer to peer databases. The approach we propose does not require additional information about schemas of peers. The main idea behind our design is that even if the schemas are structurally and syntactically different, queries can be similar in the sense that they return semantically related objects. The discovery process is the following: given two queries Q1 and Q2 over schemas S1 and S2, respectively, (1) we analyze relationships between attributes appearing in Q1 and Q2, and (2) we propagate the relationships over the remaining attributes of S1 and S2.
Combinational therapy for potential HIV-1 eradication and vaccination (2004)

Eradication of HIV would avert the pandemic high rates of deaths and save the healthcare resources in treatment and prevention costs, however, it is clear that this goal is not achievable with existing anti-HIV drugs due to HIV evolvement in great magnitude and diversity. Despite recent reports of short interfering RNA-directed silencing of HIV gene activities, there remain many challenges in overcoming the complications of HIV mutation in the management of clinical HIV-infected cells. Here we describe a combinational therapy of antiviral deoxynucleotidylated RNA hybrid transfection and interleukin-2 adjuvant treatment that was able to consistently silence 99% mutant type HIV-1 infections of T lymphocytes mediated through a novel post-transcriptional gene silencing mechanism. This combined therapy not only induced strong suppression on mixed type HIV-1 replication but also boosted the immunity and proliferation of normal T lymphocytes. The outgrowth of non-infected T cells resulted in the elimination of 76% HIV-infected cells 1 week after the combinational therapy. These findings promise to provide an immediate therapy in both acute and chronic HIV infections as well as a potential vaccination strategy for AIDS eradication.
Mutual coagulation of colloidal dispersions (1966)

A quantitative theory is presented which describes the kinetics of coagulation of colloidal systems containing more than one dispersed species. A general expression has been derived to describe the potential energy of interaction between dissimilar spherical colloidal particles, using the linear (Debye-Hückel) approximation for low surface potentials. An overall stability ratio has been defined which takes into account the possibility of interactions between like, as well as unlike, particles in the system. The errors introduced by the use of the linear approximation have been assessed in terms of their effects on the stability ratio, and found to be quite small. The theory has been used to describe the behaviour of a hypothetical system under various conditions.
A Serial Combination of Anomaly and Misuse IDSes Applied to HTTP Traffic (2005)

Combining an "anomaly" and a "misuse" IDSes offers the advantage of separating the monitored events between normal, intrusive or unqualified classes (i.e. not known as an attack, but not recognize as safe either). In this article, we provide a framework to systematically reason about the combination of anomaly and misuse components. This framework applied to Web servers lead us to propose a serial architecture, using a drastic anomaly component with a sensitive misuse component. This architecture provides the operator with better qualification of the detection results, raises lower amount of false alarms and unqualified events.
Extracapsular Extension of the Sentinel Lymph Node Metastasis: A Predictor of Nonsentinel Node Tumor Burden (2003)

ECE of the SN metastasis is a strong predictor of NSN tumor involvement. All patients with ECE of the SN metastasis should undergo mandatory completion ALND.
Lymphocyte called home: β2-adreneric neurotransmission confines T cells to lymph nodes to suppress inflammation (2014)

![Figure][1] 

Insight from Kevin Tracey



The immune and nervous systems sense changes in the environment, mobilize host responses, and establish memories of threatening events. In this issue, an important study by [Nakai et al.][2] using experimental models of T cell inflammation shows that
Marine gravity (1971)

Significant advances have been made in marine gravity during the past 4 years, including improved reliability of gravity meter measurements, development of new gravity meters, developments leading to improved ship positioning, and significant gravity surveys by an increasing number of organizations.
Size of the Largest Colorectal Cancer Liver Metastasis Impacts Recurrence and Survival (2019)

Ren, Weizheng MD; Sell, Naomi MD; Tanabe, Kenneth K. MD, FACS; Lillemoe, Keith D. MD, FACS; Ferrone, Cristina R. MD, FACS; Qadan, Motaz MD, PhD, FACS Author Information
Bisphosphonates and the risk of stroke: A systematic review and meta-analysis (2022)

A d u l t p a t i e n t s e l i g i b l e f o r bisphosphonate use I: Bisphosphonate use C: Without bisphosphonate use O: Stroke risk S: Clinical trials, cohort studies, or case-control studies. Condition being studied: Some studies have suggested that bisphosphonates may reduce the risk of stroke, while the relevant evidence is inconsistent and inconclusive. Eligibility criteria: Studies will be included in the systematic review if: (1) the studies presented outcome measurements for stroke in patients with and without bisphosphonate use; (2) they reported the relative risk (RR) of stroke between bisphosphonate users and non-users (including those without treatment or taking other antiosteoporotic agents rather than bisphosphonates), or the RR could be derived from the study's data; (3) the study designs were clinical trials, cohort studies or case-control studies; (4) they were published as original articles or with original data.
Authentication in the clouds (2010)

Cloud computing is a natural fit for mobile security. Typical handsets have input constraints and practical computational and power limitations, which must be respected by mobile security technologies in order to be effective. We describe how cloud computing can address these issues. Our approach is based on a flexible framework for supporting authentication decisions we call TrustCube (to manage the authentication infrastructure) and on a behavioral authentication approach referred to as implicit authentication (to translate user behavior into authentication scores). The combination results in a new authentication paradigm for users of mobile technologies, one where an appropriate balance between usability and trust can be managed through flexible policies and dynamic tuning.
Fractionation of Proteins by Heparin Chromatography (2008)

Heparins are negatively charged polydispersed linear polysaccharides which have the ability to bind a wide range of biomolecules including enzymes, serine protease inhibitors, growth factors, extracellular matrix proteins, DNA modification enzymes and hormone receptors. In this chromatography, heparin is not only an affinity ligand but also an ion exchanger with high charge density and distribution. Heparin chromatography is an adsorption chromatography in which biomolecules can be specifically and reversibly adsorbed by heparins immobilized on an insoluble support. An advantage of this chromatography is that heparin-binding proteins can be conveniently enriched using its concentration effect. This is especially important for separating low abundance proteins for the analysis in two-dimensional electrophoresis (2DE) or other proteomics approaches. Heparin chromatography is a powerful sample-pretreatment technology that has been widely used to fractionate proteins from extracts of prokaryotic organism or eukaryotic cells. As an example, the fractionation of fibroblast growth factors (FGFs) from the extract of mouse brain microvascular endothelial cells (MVEC) is now introduced to demonstrate the procedure of heparin chromatography.
Diffusion LMS Over Multitask Networks (2015)

The diffusion LMS algorithm has been extensively studied in recent years. This efficient strategy allows to address distributed optimization problems over networks in the case where nodes have to collaboratively estimate a single parameter vector. Nevertheless, there are several problems in practice that are multitask-oriented in the sense that the optimum parameter vector may not be the same for every node. This brings up the issue of studying the performance of the diffusion LMS algorithm when it is run, either intentionally or unintentionally, in a multitask environment. In this paper, we conduct a theoretical analysis on the stochastic behavior of diffusion LMS in the case where the single-task hypothesis is violated. We analyze the competing factors that influence the performance of diffusion LMS in the multitask environment, and which allow the algorithm to continue to deliver performance superior to non-cooperative strategies in some useful circumstances. We also propose an unsupervised clustering strategy that allows each node to select, via adaptive adjustments of combination weights, the neighboring nodes with which it can collaborate to estimate a common parameter vector. Simulations are presented to illustrate the theoretical results, and to demonstrate the efficiency of the proposed clustering strategy.
Tip-Enhanced Raman Scattering (TERS) from Hemozoin Crystals within a Sectioned Erythrocyte (2011)

Tip-enhanced Raman scattering (TERS) is a powerful technique to obtain molecular information on a nanometer scale, however, the technique has been limited to cell surfaces, viruses, and isolated molecules. Here we show that TERS can be used to probe hemozoin crystals at less than 20 nm spatial resolution in the digestive vacuole of a sectioned malaria parasite-infected cell. The TERS spectra clearly show characteristic bands of hemozoin that can be correlated to a precise position on the crystal by comparison with the corresponding atomic force microscopy (AFM) image. These are the first recorded AFM images of hemozoin crystals inside malaria-infected cells and clearly show the hemozoin crystals protruding from the embedding medium. TERS spectra recorded of these crystals show spectral features consistent with a five-coordinate high-spin ferric heme complex, which include the electron density marker band ν(4) at 1373 cm(-1) and other porphyrin skeletal and ring breathing modes at approximately 1636, 1557, 1412, 1314, 1123, and 1066 cm(-1). These results demonstrate the potential of the AFM/TERS technique to obtain nanoscale molecular information within a sectioned single cell. We foresee this approach paving the way to a new independent drug screening modality for detection of drugs binding to the hemozoin surface within the digestive vacuole of the malaria trophozoite.
Acquisition of weak GNSS signals using a new block averaging pre-processing (2008)

In this paper, we introduce a new approach for the acquisition of weak GNSS signals. For the GPS L1 signal, we utilize the replication property of the C/A code within each data bit to introduce a block averaging pre-processing (BAP) approach for improving receiver robustness against undesired signals. A large number of weighted signal blocks is coherently accumulated and synchronously averaged to obtain a single block with improved signal power. We present several properties of the proposed GNSS signals enhancement technique and we analyze its robustness against noise and different classes of interferers. Thus, we develop a software defined acquisition procedure using the efficient FFT correlation approach. We propose two acquisition algorithms based on the BAP approach. The first scheme implements the parallel code phase search in finding the 2-D spectrum peak using circular cross-correlations. In the second scheme, we exploit the BAP for a fast acquisition performing the frequency estimation prior to the 1-D code-phase search.
Analysis and Design of an Ultralow-Power CMOS Relaxation Oscillator (2010)

This paper presents the design of a low-voltage ultralow-power relaxation oscillator without external components. The application field for this oscillator is the clock generation of low-power wake-up functions for battery-operated systems. A detailed analysis of the oscillator, including the temperature performance, is derived and verified with experimental results. The oscillator operates at a typical frequency of 3.3 kHz and consumes 11 nW from a 1-V supply at room temperature, and a temperature drift of less than 500 ppm/°C is achieved over the temperature range of -20°C to 80°C. An efficient design implementation has resulted in a cell area of 0.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a standard 0.35- μm digital CMOS technology.
A Detailed Modelling of the Spray Ignition Process in Diesel Engines (2000)

The Shell autoignition model with the value of the pre-exponential factor in the rate of production of the intermediate agent (A f4) in the range between 3×106 and 6×1O6 has been applied to the detailed modelling of the ignition process in monodisperse and polydisperse sprays based on a computational fluid dynamics (CFD) code. The mass balance in the Shell model has been improved to ensure bener physical consistency and more effective numerical implementation. Based on the analysis of the ignition in a monodisperse spray it is pointed out that in the case of droplets with the initial radius (R d0) about or greater than 6 μm the physical ignition delay dominates over the chemical ignition delay, while for the smaller droplets with R d0≤2.5 μm the opposite is true. The start of the ignition processis predicted near the periphery of both monodisperse and polydisperse sprays in agreement with current understanding of this phenomenon. The observed ignition delay for a monodisperse spray agrees with the available experimental data. The ignition stage of the polydisperse Diesel combustion predicted by the model agrees with available experimental data for a medium duty truck Diesel engine, provided that the fine tuning of the parameter A f4 is performed and additional constants. such as concentration limits, are introduced.
Copper-Catalyzed Synthesis of Vinyl Sulfides (2004)

[reaction: see text] We report a method for the synthesis of vinyl sulfides using the soluble copper(I) catalyst [Cu(phen)(PPh3)2]NO3. The desired vinyl sulfides are obtained in good to excellent yields, with retention of stereochemistry. This protocol tolerates a wide variety of functional groups or substrates, is palladium-free, and does not require the use of expensive or air-sensitive additives.
Author response: Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex (2015)

The human brain is essentially organised into modules made from groups of connected neurons. A part of the brain at the back of the head, called the cerebellum, is organised into particularly well-defined modules and is important for fine-tuning and learning new movements. However, it is not clear if the pattern of connections between modules in the brain is broadly the same across different animals from the same species, or if it varies between individuals. This is partly because it has not been possible to identify the same cells across different individual animals, and thus measure whether the connections are different. Valera et al. used genetically engineered mice that produced a fluorescent marker in specific subsets of easily identifiable neurons in the cerebellum known as Purkinje cells. These groups of labeled Purkinje cells helped identify the boundaries of modules in the cerebellum. Valera et al. then stimulated another group of neurons, called the granule cells, that connect to Purkinje cells from several different modules. Measuring the resulting changes in the electrical activity of the Purkinje cells revealed the pattern of connections between these two types of neurons. These experiments showed that granule cells can connect Purkinje cells from distant modules and that neighbouring Purkinje cells often display similar connection patterns. Valera et al. also found that Purkinje cells from different animals but at the same location in the cerebellum had similar patterns of connections with granule cells. This suggests that, in identified modules, there is little variability in connection patterns between individuals. However, the patterns of connectivity could be altered by processes related to learning, indicating that they can be organized in different ways and still work. Further experiments then showed that different individuals display consistent patterns of connectivity between granule cells and other major cell types in the cerebellum. This finding suggests that while the basic modules in the cerebellum are similar across different individuals, the connections between modules can be shaped by experience. An important challenge for the future is now to understand how the connected modules combine the information they receive and drive the output of the cerebellum. This knowledge will help better describe how movements are controlled.
Toward overcoming pyrethroid resistance in mosquito control: the role of sodium channel blocker insecticides (2023)

ABSTRACT Diseases spread by mosquitoes lead to death of 700,000 people each year. The main way to reduce transmission is vector control by biting prevention with chemicals. However, the most commonly used insecticides lose efficacy due to the growing resistance. Voltage-gated sodium channels (VGSCs), membrane proteins responsible for the depolarizing phase of an action potential, are targeted by a broad range of neurotoxins, including pyrethroids and sodium channel blocker insecticides (SCBIs). Reduced sensitivity of the target protein due to the point mutations threatened malaria control with pyrethroids. Although SCBIs – indoxacarb (a pre-insecticide bioactivated to DCJW in insects) and metaflumizone – are used in agriculture only, they emerge as promising candidates in mosquito control. Therefore, a thorough understanding of molecular mechanisms of SCBIs action is urgently needed to break the resistance and stop disease transmission. In this study, by performing an extensive combination of equilibrium and enhanced sampling molecular dynamics simulations (3.2 μs in total), we found the DIII-DIV fenestration to be the most probable entry route of DCJW to the central cavity of mosquito VGSC. Our study revealed that F1852 is crucial in limiting SCBI access to their binding site. Result explain the role of the F1852T mutation found in resistant insects and the increased toxicity of DCJW compared to its bulkier parent compound, indoxacarb. We also delineated residues that contribute to both SCBIs and non-ester pyrethroid etofenprox binding and thus could be involved in the target site cross-resistance. Abstract Figure
GENETIC VARIANCE OF WEIGHT AND LENGTH IN INFANT TWINS (1987)

A population-based cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center, from July 1, 1976 to December 31, 1980 was identified. Body weight and length were measured at 14 days and at one, three, six, nine, and 12 months of age. Statistically significant genetic variance was found for both body weight and length at each data point. Heritability for body weight increased from 0.28 at 14 days to 0.64 at one year. Corresponding values for body length were 0.16 and 0.48.