gebhart/patrepeval huggingface dataset:
β-Melanocyte-Stimulating Hormone Immunoreactivity in Human Pituitaries and Ectopic Adrenocorticotropin-Producing Tumors* (1980)

Using β-MSH and a-endorphin RIA in conjunction with gel filtration and isoelectric focusing, we examined extracts of five human pituitary glands and seven tumors obtained from patients with the ectopic ACTH syndrome for heterogeneity of immunoreactive β-MSH. In the extraction experiments with porcine anterior pituitary, we found that the boiling water as well as the 0.2-N HC1 extraction method prevented β-MSH formation during extraction. The extracts prepared by the boiling water extraction method were applied on a Sephadex G-50 column and subjected to β- MSH RIA. For identification of βMipotropic hormone (LPH) and γ-LPH peaks obtained by gel filtration, both β-MSH and a-endorphin RIAs were carried out simultaneously in each fraction because β-LPH contained the amino acid sequences of both β-MSH and a-endorphin in its structure and reacted in both RIA systems, but γ-LPH lacked the amino acid sequence of aendorphin and reacted only in the β-MSH RIA. The β-LPH, γ- LPH, and β-MSH peaks were examined further by isoelectric focusing. The gel filtration patterns of all five human pituitaries revealed β-LPH and γ-LPH peaks but no β-MSH peak. β-LPH was a major component of immunoreactive β-MSH in the human pituitary. The gel filtration patterns of all seven ecto pic ACTHproducing tumors revealed β-MSH and γ-LPH peaks, but a clear peak of β-LPH was observed only in the three tumor extracts. Isoelectric focusing could identify β-LPH and β-LFH because β-LPH had a pi of 4.9 and y-LPH had a pi of 4.6. The pi of tumor y-LPH was the same as that of pituitary γ-LPH. The β- MSH comprised 3-55% of the total immunoreactive β-MSH.There were two types of β-MSH peaks on the gel filtration; one corresponded to human type β-MSH and the other co: -responded to porcine type β-MSH. Moreover, isoelectric focusing revealed that the human type β-MSH found in the tumor tissue had a pi of 7.5, which was the pi of synthetic human /S-MSH, and that the porcine type /2-MSH had a pi of 5.5, which was the pi of highly purified porcine β-MSH. These data indicate that γ-LPH is present in the human pituitary and the ectopic ACTH-producing tumor. They further indicate that β-MSH is produced in the ectopic ACTH-producing tumor and that there are two types of β-MSH: human and porcine.
Directional beam control using on/off-axis high-efficiency diffractive optics integrated on substrate-emitting wertical-cavity lasers (1995)

Vertical-cavity surface-emitting lasers (VCSELs) are very attractive for many integrated photonic systems. Two-dimensional arrays are required to provide the compact geometry needed by many optical interconnect systems.1 However, without a discrete optical element, such as a focusing lens, the diverging Gaussian beam can introduce cross talk if the adjacent receivers are within the spread of the beam diameter. In addition, the direction of the output beam limits many applications to on-axis system configurations. Integrating diffractive optical elements on the transparent substrate of a substrate-emitting VCSEL provides a method for controlling the direction and minimizing the divergence of the exiting beam.2
Non-allelic homologous recombination leading to premature transcription termination in the ARSB gene as a novel cause of Mucopolysaccharidosis type VI (2022)

Mucopolysaccharidosis type VI (MPS VI) is a lysosomal storage disorder associated with pathogenic variants in the ARSB gene. Herein, we present a novel type of ARSB mutations, which is an insertion of the LHFPL2 gene fragment derived from unequal non-allelic homologous recombination between these two genes. The 52 kb insertion, containing the LHPL2 exon 3, was identified in reverse complement orientation deep in the intron 4 of ARSB using whole genome sequencing. Subsequent RNA analysis determined its deleterious effect, which is premature transcription termination. Two mobile genetic elements of the L1 class with high sequence similarity were identified in both genes at the site of recombination and their close spatial proximity is suggested to favor structural rearrangements in this locus. The recombination was identified in compound heterozygous state with the nonsense variant c.966G&gt;A (p.Trp322*) in patient with an early-onset form of MPS VI. Almost complete absence of the full-length ARSB mRNA isoform expression from both alleles correlates well with a severe phenotype of the patient. The results of our study expand mutational spectrum of the ARSB gene towards complex structural variants and novel molecular-genetic mechanisms.
Does Wireless Capsule Endoscopy Affect Outcomes After Ileal Pouch-Anal Anastomosis in IBD Patients Treated With Anti-TNF Agents? (2012)

patients, CE diagnosed proximal small bowel involvement, revealing CD related lesions, out of the reach of the standard endoscope. At the time of CE measurement of CRP was 12,8 6 26,5 mg/dl. The mean LS was 1387 6 1693,8, range 112-6150 and the mean CECDAI was 7,1 6 5.7, range 1-22. In our cohort, CECDAI demonstrated a good correlation with CRP levels (rs 0.467, P < 0.002), better than LS (rs 0.357, P < 0.022). Strong correlation between LS and CECDAI was demonstrated (rs 0.683, P < 0.01). Linear regression analysis demonstrated that LS thresholds of 135 and 790 correspond with CECDAI levels of 5 and 7, respectively. The presence of high levels of CRP was significantly related to CECDAI !7 (P < 0.05), but no association was demonstrated to LS!790. CONCLUSION(S): We demonstrate a strong correlation between these two scores and calculate the CECDAI levels corresponding to LS threshold of 135 and 790. In our cohort, we demonstrate a significant association between CRP and CECDAI, better than LS. Prospective studies may in the future support the use of both of the scores in follow-up of patients with isolated small-bowel CD to assess response to medical therapy, such as others endoscopic scores used for ileocolonic CD.
Sparsity-Driven Reconstruction Technique for Microwave/Millimeter-Wave Computational Imaging (2018)

Numerous prototypes of computational imaging systems have recently been presented in the microwave and millimeter-wave domains, enabling the simplification of associated active architectures through the use of radiating cavities and metasurfaces that can multiplex signals encoded in the physical layer. This paper presents a new reconstruction technique leveraging the sparsity of the signals in the time-domain and decomposition of the sensing matrix.
Introducing NMR strategies to define water molecules that drive metal binding in a transcriptional regulator (2023)

• wNOE/wROE experiments allow for the detection of site-specific protein hydration dynamics. • Hydration dynamics of metal binding are characterized complementing NMR, MD and ITC. • Zinc binding is favored by solvent release from the protein hydration shell upon metal binding. • Solvent entropy controls zinc binding and determines allosteric regulation of DNA binding. Staphylococcus aureus CzrA is a paradigmatic member of the ArsR family of transcriptional metalloregulators, which are critical for the bacterial response to stress. Zinc binding to CzrA, which induces DNA derepression, is entropically driven, as shown by calorimetry. A detailed equilibrium dynamics study of different allosteric states of CzrA revealed that zinc induces an entropy redistribution that controls for DNA binding regulation; however, this change in conformational entropy only accounts for a small net contribution to the total entropy. This difference between the change in conformational entropy vs. total entropy of zinc binding implies a significant contribution of solvent molecule rearrangements to this equilibrium. However, the absence of major structural changes suggests that solvent rearrangements occur mainly on the protein surface and/or from zinc desolvation, concomitant with a dynamical redistribution of conformational entropy. Previous results also suggest that zinc binding not only leads to a redistribution of protein internal dynamics, but also release of water molecules from the protein surface. In turn, these water molecules may make a significant contribution to the allosteric response that results in dissociation from the DNA. Quantifying the differential hydration of two conformational states that share very similar crystal structures and then correlating this with the protein's solvent entropy change constitutes an unresolved problem, even when thermodynamics suggest a significant contribution of solvent entropy. Here, we present different avenues to dissect hydration dynamics in a metal-binding transcriptional regulator that provide different insights into this complex problem. We explore primary solution NMR tools for probing protein–water interactions: the laboratory frame nuclear Overhauser effect (NOE) and its rotating frame counterpart (ROE) between long-lived water molecules and the protein residues. The wNOE/wROE ratio is a promising tool for the detection of hydration dynamics near the surface of a protein in a site-specific manner, minimizing contamination from bulk solvent. Molecular dynamics simulations and computational methods designed to provide a spatially resolved picture of solvent thermodynamics were also employed to provide a more complete panorama of solvent redistribution.
Studies on Anthracenes. 1. Human Telomerase Inhibition and Lipid Peroxidation of 9-Acyloxy 1,5-Dichloroanthracene Derivatives. (2001)

The synthetically useful approaches to 9-acyloxy 1,5-dichloroanthracene derivatives are reported. The system selectively reduces the carbonyl group flanked by the peri substituents of the anthracenediones to give the corresponding 1,5-dichloro-9(10H)-anthracenone. Simple regioselective acylation of anthracenone is applied with appropriate acyl chlorides in CH2Cl2 with catalytic amount of pyridine to give the novel 9-acyloxy 1,5-dichloroanthracene derivatives. Considerable interest has developed in the mechanism of how anthracenone achieves this desirable selectivity. In an attempt to understand the mechanism of this reaction, solid-state structures of anthracene derivatives have been obtained. In addition, the inhibition of lipid peroxidation in model membranes was determined as was their ability to inhibit the telomere-addition function of the human telomerase enzyme together with their inhibition of the Taq polymerase enzyme. In contrast to (+)-alpha-tocopherol, 3b, 3c, 3d, 3g, and 3i do not enhance lipid peroxidation in model membranes. Implications for 9-acyloxy 1,5-dichloroanthracene analogues as potential anticancer agents are discussed.
COX-2 inhibitors in breast cancer (2005)

The cyclooxygenase (COX) enzymes catalyse the rate-limiting step of conversion from arachidonic acid to prostaglandins (PGs). The enzyme exists in two isoforms COX-1 and COX-2. The inducible COX-2 isoform has been shown to be present in up to 80% of breast cancers, high expression correlating with low rates of apoptosis, increased angiogenesis and poor prognosis. Both non-steroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors to COX-2 have been associated with anti-tumoural properties, decreasing the rates of tumour growth, increasing apoptosis and inhibiting angiogenesis. A variety of cellular mechanisms have been suggested, but the exact mechanisms of action remain unclear. COX-2 inhibitors have the potential to be used either alone, or in combination with other agents such as aromatase inhibitors (AIs), monoclonal antibodies (i.e. trastuzumab) or chemotherapeutic agents as novel therapeutic strategies against breast cancer. However the potential cardiac toxicity of the COX-2 selective compounds needs to be fully addressed, with the future development of either safe dosing regimes or new compounds.
Proteolysis Of Goat .beta.-Casein by Calf Rennet under Various Factors Affecting the Cheese Ripening Process (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProteolysis Of Goat .beta.-Casein by Calf Rennet under Various Factors Affecting the Cheese Ripening ProcessAntonio-Jose Trujillo, Buenaventura Guamis, and Carmen CarreteroCite this: J. Agric. Food Chem. 1995, 43, 6, 1472–1478Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jf00054a011https://doi.org/10.1021/jf00054a011research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BENDABLE VS. ANGULATED DENTAL IMPLANTS: CONSIDERATION OF ELASTIC AND PLASTIC MATERIAL PROPERTIES BASED ON EXPERIMENTAL IMPLANT MATERIAL DATA AND FEA (2008)

Assuming that all other parameters are equal, bendable (basal) implants show a more even stress distribution along the vertical implant region than identically shaped implants with a machine-angulated area. Bendable basal implants therefore probably resist masticatory forces better than pre-angulated, machined implants, and unbent implants which provide a thin region in the vertical implant area.
Enhanced Metabolic Stability and Protein‐Binding Properties of Artificial α Helices Derived from a Hydrogen‐Bond Surrogate: Application to Bcl‐xL (2005)

Künstliche α-Helices erhält man, indem man anstelle einer Wasserstoffbrücke zwischen den Resten i und i+4 eine C-C-Bindung einfügt. Auf diese Weise werden die helicalen Konformationen biologisch wichtiger Peptide stabilisiert (1, grau: interne Einschränkung). α-Helices mit Wasserstoffbrückensurrogaten, die Bak BH3 (2, gelb) imitieren, können mit hoher Affinität an den erwarteten Proteinrezeptor Bcl-xL (2, grün) binden und werden nicht proteolytisch abgebaut.
Volumetric assessment of emphysema on low-dose screening CT scans (2003)

A study was performed to test whether automated computer analysis of low-dose helical CT scans can accurately estimate the degree of emphysema. We characterized the severity of emphysema on low-dose high-resolution (2.5 mm slice thickness) CT scans into 4 categories (normal, mild, moderate, and severe) as determined by a thoracic radiologist. From our database we chose 80 cases (20 within each category) for analysis. Our analysis system segments the lung parenchyma from surrounding structures and computes an emphysema index as the volumetric percentage of emphysema for the entire lung volume using a dual thresholding technique. One-way analysis of variance was used to assess the emphysema index. For those cases classified as normal, the emphysema index was 11.74 &plusmn; 1.24 (mean &plusmn; sem), for mild it was 15.00 &plusmn; 1.31, for moderate it was 16.91 &plusmn; 1.72, and for severe it was 26.77 &plusmn; 1.73. The differences were statistically significant (p &lt; 0.0001) and showed an increasing score with increasing severity of emphysema. Our system provides a useful index of the degree of emphysema present. Use of the system allows subjects undergoing lung cancer screening studies to have the extent of their emphysema quantified on a year-to-year basis.
ChemInform Abstract: 2‐Trifluoromethyl‐Substituted Amino Acids. Part 20. Incorporation of . alpha.‐Trifluoromethyl‐Substituted α‐Amino Acids into the N‐ and C‐Terminal Position of Azapeptides. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Too Many Stars and Not Enough Sky: Language and Ethnicity among the Thakali of Nepal (1997)

Too many stars and not enough sky: Language and ethnicity among the Thakali of Nepal
Microfluidic Rheology of Non-Newtonian Liquids (2007)

We investigate the rheological properties of a non-Newtonian glass-former liquid within lithographically defined microchannels in the range of temperatures above the vitrification region. The non-Newtonian behavior of the fluid, as evidenced by rotational rheology, is well described by a power law dependence of the viscosity on the shear rate. Taking into account such non-Newtonian character in the equations for the microfluidic motion, we relate the penetration dynamics into capillaries with the liquid rheological properties. The temperature dependence of the viscosity, determined over 1 order of magnitude in the temperature range 286-333 K and for shear rates between 0.07 and 1 s-1, can be described by a Vogel-Fulcher-Tamman law, consistent with the fragile nature of the investigated compound. Microfluidics is a promising analytical approach for the investigation of the rheology of non-Newtonian fluids within confined microenvironments.
Anesthesia and Monitoring in Small Laboratory Mammals Used in Anesthesiology, Respiratory and Critical Care Research: A Systematic Review on the Current Reporting in Top-10 Impact Factor Ranked Journals (2015)

The present systematic review revealed insufficient reporting of anesthesia and euthanasia methods throughout experimental studies in small laboratory mammals. Specific guidelines for anesthesia and euthanasia regimens should be considered to achieve comparability, quality of animal experiments and animal welfare. These measures are of special interest when translating experimental findings to future clinical applications.
The Ecstatic Spiral (2002)

(1) Background: Incontinence and its complications pose great difficulties in the care of the disabled. Currently, invasive incontinence monitoring methods are too invasive, expensive, and bulky to be widely used. Compared with previous methods, bowel sound monitoring is the most commonly used non-invasive monitoring method for intestinal diseases and may even provide clinical support for doctors. (2) Methods: This paper proposes a method based on the features of bowel sound signals, which uses a BP classification neural network to predict bowel defecation and realizes a non-invasive collection of physiological signals. Firstly, according to the physiological function of human defecation, bowel sound signals were selected for monitoring and analysis before defecation, and a portable non-invasive bowel sound collection system was built. Then, the detector algorithm based on iterative kurtosis and the signal processing method based on Kalman filter was used to process the signal to remove the aliasing noise in the bowel sound signal, and feature extraction was carried out in the time domain, frequency domain, and time-frequency domain. Finally, BP neural network was selected to build a classification training method for the features of bowel sound signals. (3) Results: Experimental results based on real data sets show that the proposed method can converge to a stable state and achieve a prediction accuracy of 88.71% in 232 records, which is better than other classification methods. (4) Conclusions: The result indicates that the proposed method could provide a high-precision defecation prediction result for patients with fecal incontinence, so as to prepare for defecation in advance.
Summarization of user-generated sports video by using deep action recognition features (2018)

Automatically generating a summary of a sports video poses the challenge of detecting interesting moments, or highlights, of a game. Traditional sports video summarization methods leverage editing conventions of broadcast sports video that facilitate the extraction of high-level semantics. However, user-generated videos are not edited and, thus, traditional methods are not suitable to generate a summary. In order to solve this problem, this paper proposes a novel video summarization method that uses players’ actions as a cue to determine the highlights of the original video. A deep neural-network-based approach is used to extract two types of action-related features and to classify video segments into interesting or uninteresting parts. The proposed method can be applied to any sports in which games consist of a succession of actions. Especially, this paper considers the case of Kendo (Japanese fencing) as an example of a sport to evaluate the proposed method. The method is trained using Kendo videos with ground truth labels that indicate the video highlights. The labels are provided by annotators possessing a different experience with respect to Kendo to demonstrate how the proposed method adapts to different needs. The performance of the proposed method is compared with several combinations of different features, and the results show that it outperforms previous summarization methods.
ChemInform Abstract: Ring Opening of 3(2H)‐Pyrazolones by Oxidation with Periodate. (1989)

Abstract Oxidative cleavage of the pyrazolones (I), (III), (V), or (VI) with sodium periodate yields the tricarbonyl compounds (II), (IV), or (VII).
Determination of Antioxidant and Hepatoprotective Ability of Flavanoids of Cichorium intybus (2014)

ABSTRACT The hydroalcoholic fraction of the leaves of Cichorium intybus was tested for the presence of flavanoids and the hepatoprotective activity of this flavanoid containing extract was tested against hydrogen peroxide induced toxicity in HepG2 cell lines. A dose dependent increase in the viability/restoring effect was observed when hydrogen peroxide exposed HepG2 cells were treated with the different concentrations (100ng/ml- 200µg/ml) of the hydroalcoholic fraction. It was observed that in the presence of 0.5mM hydrogen peroxide cell viability was reduced from 100% to 66% and with 1mM hydrogen peroxide, it was further reduced to 19.3%. The damaging effect was restored in the presence of the hydroalcoholic fraction of Cichorium intybus leaf extract, in a concentration dependent manner. This study can further lead to the isolation and characterization of the flavanoids of the plant extract responsible for the hepatoprotective properties. Keywords : - Antioxidant, Hepatoprotective, Liver cell culture, HepG2, Flavanoids, Hydrogen peroxide.
Evaluation of properties of various type CdTe hard x-ray detectors (2005)

M-π -n detector and Schottky detector which were different barriers were evaluated by measuring spectrum as imaging detectors. These spectrum performances showed that the effect of polarization in these detectors was similarly occurred. The current-time characteristics and capacitance-time characteristics were measured for the detectors and it was found that these characteristics were due to the effect of polarization.