gebhart/patrepeval huggingface dataset:
Biological activities of resveratrol and its analogs (2002)

Resveratrol (3,4',5-trihydroxy-trans-stilbene), a phytoalexin found in grape skins, peanuts, and red wine, has been reported to exhibit a wide range of biological and pharmacological properties. It has been speculated that dietary resveratrol may act as an antioxidant, promote nitric oxide production, inhibit platelet aggregation and increase high-density lipoprotein cholesterol, thereby serving as a cardioprotective agent. Recently, resveratroi was shown to function as a cancer chemopreventive agent, and there has been a great deal of experimental effort directed toward defining this effect. In addition, resveratrol exhibits antiinflammatory, neuroprotective and antiviral properties. This review summarizes the recent advances that have provided new insights into the molecular mechanisms underlying the promising properties of resveratrol, including cyclooxygenase, nitric oxide synthase and cytochrome P450 inhibition, as well as cell cycle effects, apoptosis modulation and hormonal activity.
Respiratory Response to Arm Elevation in Patients with Chronic Airflow Obstruction (1991)

We have shown that patients with chronic airflow obstruction (CAO) complain of disabling dyspnea when performing seemingly trivial tasks with unsupported arms. Surprisingly little is known about the metabolic and ventilatory responses to unsupported upper extremity activity even though some of the muscles of the upper torso and shoulder girdle are used to perform simple and complex everyday tasks as well as partake in ventilation. To determine the effect of simple arm elevation in 20 patients with CAO we studied their lung function, VO2, VCO2, and VE, with arms down at the side (AD), during 2 min with arms extended forward up to shoulder level (AE), and during recovery. To determine the pattern of ventilatory muscle recruitment we also measured endoesophageal (Ppl), gastric (Pg), and transdiaphragmatic (Pdl) pressures. In five of the patients the electromyographic signal (EMG) of the sternocleidomastoid (Sm) muscle was recorded and analyzed in its time domain (amplitude) and power spectrum density (median frequency). Within 30 s of arm elevation VO2, VCO2, and VE rose and remained elevated for 1 min after the arms were lowered. The increase in VE resulted from increases in respiratory rate and minimal rise in tidal volume (VT). With AE, FEV1 decreased by 5% (p less than 0.02) but FRC increased by 2% (p less than 0.05). Peak inspiratory pressure (Pimax) dropped from 54 +/- 4 to 48 +/- 4 cm H2O (p less than 0.005); Pdimax remained unchanged. Immediately after raising the arms Pgi, inspiratory swing in Pdi (delta Pdi), end-expiratory Ppl, and end-expiratory Pg increased significantly.(ABSTRACT TRUNCATED AT 250 WORDS)
Prostaglandins, Leukotrienes and Bone (2004)

This chapter contains sections titled: PG Production in Bone Role of PGs in Bone Resorption Role of PGs in Bone Formation Effects of NSAIDs on Bone in Humans Leukotrienes and Bone Summary Acknowledgements References
1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease (2016)

In patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFRCT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up. (The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts [PLATFORM]; NCT01943903).
Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients (2021)

Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ failures. Endogenously released catecholamines are often inefficient to maintain blood pressure, and low reactivity to exogenous catecholamines with risk of sympathetic overstimulation is well documented in septic shock. In this context, apelinergics are efficient and safe inotrope and vasoregulator in rodents. However, their utility in a larger animal model as well as the limitations with regards to the enzymatic breakdown during sepsis, need to be investigated. The therapeutic potential and degradation of apelinergics in sepsis were tested experimentally and in a cohort of patients. (1) 36 sheep with or without fecal peritonitis-induced septic shock (a large animal experimental design aimed to mimic the human septic shock paradigm) were evaluated for hemodynamic and renal responsiveness to incremental doses of two dominant apelinergics: apelin-13 (APLN-13) or Elabela (ELA), and (2) 52 subjects (33 patients with sepsis/septic shock and 19 healthy volunteers) were investigated for early levels of endogenous apelinergics in the blood, the related enzymatic degradation profile, and data regarding sepsis outcome. APLN-13 was the only one apelinergic which efficiently improved hemodynamics in both healthy and septic sheep. Endogenous apelinergic levels early rose, and specific enzymatic breakdown activities potentially threatened endogenous apelin system reactivity and negatively impacted the outcome in human sepsis. Short-term exogenous APLN-13 infusion is helpful in stabilizing cardiorenal functions in ovine septic shock; however, this ability might be impaired by specific enzymatic systems triggered during the early time course of human sepsis. Strategies to improve resistance of APLN-13 to degradation and/or to overcome sepsis-induced enzymatic breakdown environment should guide future works.
APS, ERP and MES systems integration for semiconductor backend assembly (2004)

In this paper, the system integration of an Advanced Planning and Scheduling (APS) system with Enterprise Resource Planning (ERP) and Manufacturing Execution System (MES) for a Semiconductor Backend Assembly environment is described. The company is one of the worldwide market leaders in semiconductor packaging technology. SIMTech was responsible for the implementation of the Planning & Scheduling functions through its APS application which is called Gintic Scheduling System (GSS). GSS system has been integrated with the other two key manufacturing software systems, namely ERP and MES, with the CIM framework. This paper emphasizes the system integration between the GSS and the customer's existing ERP and MES systems. The paper starts with a broader overview of the APS, ERP and MES systems with the focus on the linkage of APS with ERP and APS with MES. It then introduces the brief background information of the implementation and the integration methodology. Detailed work of the integration is laid out in the fond of integration model structure and illustrated by the system integration mechanism. Various data types that need to be integrated are also elaborated. Further discussions continue with the practical implementation issue like the required frequency of data integration and also the two approaches of data transfer. Finally the paper shares the experiences and lessons the team has learned through the implementation process and concludes the essence of the system integration work.
“What I thought was so important isn’t really that important”: international perspectives on making meaning during the first wave of the COVID-19 pandemic (2021)

The paper provides a detailed overview of the methodology, the main themes identified inductively in the stories and differences according to select demographic variables. We identify several major ways of making meaning of the pandemic. The pandemic has impacted many aspects of people's lives which give it meaning, no matter where they live.
Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma (2022)

As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.
Association Between Recent Ultraviolet Radiation Exposure and Cutaneous Beta Human Papillomavirus Infection (2019)

Abstract Keratinocyte carcinoma (KC), comprised of squamous cell carcinoma and basal cell carcinoma, is the most common cancer in the United States. The effects of ultraviolet radiation (UVR), an established risk factor for KC, on cutaneous human papillomavirus (HPV) infection, a suggested risk factor currently under investigation, are not well established. We assessed cross sectional associations between UVR exposure and cutaneous beta HPV infection, using data obtained from the Viruses in Skin Cancer Study (VIRUSCAN), a prospective cohort study conducted at the Moffitt Cancer Center and the University of South Florida. Methods: Eyebrow hairs (EBH), skin swabs (SSW) and spectrophotometer-based measurements of recent UVR exposure were obtained from 1,179 skin cancer screening patients enrolled in the VIRUSCAN study. Viral DNA was measured using a multiplex PCR assay for 46 beta HPV types in both skin swab samples and eyebrow hair follicles. Logistic regression was used to examine the association between UVR exposure and cutaneous HPV infection in individual sites. Ordinal logistic regression was used to examine the effect of UVR exposure on the trend of having the same HPV infection across two sites, adjusted for age and sex. Results: Patients with higher UVR exposure were more likely to test positive for beta HPV 19, 47, 100 and 145 in EBH. In SSW, beta 38, 49, 76, 100, 124 were positively associated with UVR exposure. When considering viral infection across two sites, we found UVR exposure to be significantly associated with the odds of having infection in both EBH and SSW for beta HPV 19 (OR = 1.12, 95% CI: 1.03–1.23, p-trend = 0.04), 38 (OR = 1.08, 95% CI: 1.04–1.13, p-trend &amp;lt; 0.01), 76 (OR = 1.06, 95% CI: 1.00–1.12, p-trend = 0.01), and 100 (OR = 1.10, 95% CI: 1.04–1.17, p-trend = 0.01). Conclusions: UVR exposure is positively associated with beta cutaneous HPV at the type level, in both individual sites and across skin swab and eyebrow hair. Future research is needed to better understand the biological mechanisms mediating the associations between UVR and cutaneous HPV infection.
Implementation of threads as an operating systems project (2008)

In this paper the author describes a two-part programming assignment that has been used in an undergraduate operating systems course. The assignment is to write a user-level thread library, similar to the POSIX pthreads library, for a Unix or linux system.
HLA-DO is an intracellular class II molecule with distinctive thymic expression (1997)

The status of the HLA-DNA and -DOB genes in the HLA class II region has remained unclear for several years. Weak mRNA transcripts from each locus can be detected in B cells and some other cell types, but the issues of whether proteins are generated and, if so, whether they acquire partner chains to form class II heterodimers have not been resolved. The products of the homologous murine genes pair with each other to form the H-20 heterodimer. We now report that the products of HLA-DNA and -DOB are expressed as a heterodimer in humans, HLA-DO. It is expressed in various class II-positive cells including dendritic cells. The heterodimer associates with invariant chain and has a relatively short half-life. Its subcellular distribution differs from HLA-DR such that it is not expressed at the cell surface although it is found in some DR-containing compartments, suggesting a role at the intracellular stage of class II function. In the thymus, subpopulations of cells in both cortex and medulla, including HLA-DR+ and DR- cells, are HLA-DO+. Hassall's corpuscles, a medullary site of thymocyte death, are ringed by HLA-DO+ epithelium. This unusual pattern of expression may suggest a specialized role for HLA-DO in the thymus.
The alkaloids of Brachyglottis hectorii (2005)

The pyrrolizidine alkloids senecionine, retrorsine, clivorine, petasinine (2-O-angelylpetasinecine, and hectorine (9-O-angelylpetasinecine) were isolated from Brachyglottis hectori.
Binary Probes for Nucleic Acid Analysis (2010)

The advances in the development of binary probe (BPs) and their improved selectivity in comparison with other hybridization-based techniques were studied. The first BP, which used Förster resonance energy transfer (FRET), was suggested in 1988. A commonly adopted BP architecture employs the different affinity mode BPs. In this design one strand with a longer analyte binding arm binds tightly to the position abutting to the single-nucleotide polymorphisms (SNP) site. A second shorter analyte binding arm interrogates the SNP site by forming stable hybrid only with the perfectly matched sequence. The design of BPs employs self-assembly of more than two nucleic acid components. The same principle is adopted by DNA nanotechnology, which deals with constructing objects and functionally active assemblies from DNA molecules. Newly designed constructs based on aptamers, DNA junctions, and DNA enzymes offer an opportunity to utilize DNA probes that avoid direct covalent attachment with organic dyes.
Infant Air and Bone Conduction Tone Burst Auditory Brain Stem Responses for Classification of Hearing Loss and the Relationship to Behavioral Thresholds (2009)

AC- and BC-TBABR results can be readily obtained in young infants under natural sleep and were used to classify the type of HL based on the absolute threshold and the size of the ABG. Differences in wave V latency functions for TBABR by AC and BC and wave I and V latencies of the high-level click ABR also distinguish between infants with and without TBABR ABGs. Ear-specific behavioral responses can be obtained at levels under 20 dB HL in normal-hearing infants younger than 1 yr using VRA, and these behavioral thresholds correlate well with TBABR thresholds obtained on average 6.5 mo previously in this population. The current results suggest that protocols for obtaining AC- and BC-TBABR and behavioral thresholds that meet guidelines for early intervention are clinically feasible.
Secure Internet banking authentication (2006)

This article classifies common Internet banking authentication methods regarding potential threats and their level of security against common credential stealing and channel breaking attacks, respectively. The authors present two challenge/response Internet banking authentication solutions, one based on short-time passwords and one certificate-based, and relate them to the taxonomy above. There further outline how these solutions can be easily extended for nonrepudiation (that is, transaction signing), should more sophisticated content manipulation attacks become a real problem. Finally, they summarize their view on future requirements for secure Internet banking authentication and conclude by referencing real-live implementations
Development and Validation of Stability-Indicating HPLC Methods for Quantitative Determination of Pravastatin, Fluvastatin, Atorvastatin, and Rosuvastatin in Pharmaceuticals (2009)

Abstract High-performance liquid-chromatographic (HPLC) methods were validated for determination of pravastatin sodium (PS), fluvastatin sodium (FVS), atorvastatin calcium (ATC), and rosuvastatin calcium (RC) in pharmaceuticals. Two stability-indicating HPLC methods were developed with a small change (10%) in the composition of the organic modifier in the mobile phase. The HPLC method for each statin was validated using isocratic elution. An RP-18 column was used with mobile phases consisting of methanol–water (60:40, v/v, for PS and RC and 70:30, v/v, for FVS and ATC). The pH of each mobile phase was adjusted to 3.0 with orthophosphoric acid, and the flow rate was 1.0 mL/min. Calibration plots showed correlation coefficients (r) > 0.999, which were calculated by the least square method. The detection limit (DL) and quantitation limit (QL) were 1.22 and 3.08 µg/mL for PS, 2.02 and 6.12 µg/mL for FVS, 0.44 and 1.34 µg/mL for ATC, and 1.55 and 4.70 µg/mL for RC. Intraday and interday relative standard deviations (RSDs) were <2.0%. The methods were applied successfully for quantitative determination of statins in pharmaceuticals.
Perceptual-components architecture for digital video (1990)

A perceptual-components architecture for digital video partitions the image stream into signal components in a manner analogues to that used in the human visual system. These components consist of achromatic and opponent color channels, divided into static and motion channels, further divided into bands of particular spatial frequency and orientation. Bits are allocated to an individual band in accord with visual sensitivity to that band and in accord with the properties of visual masking. This architecture is argued to have desirable features such as efficiency, error tolerance, scalability, device independence, and extensibility.
Expression of CRHR1 and CRHR2 in Mouse Pituitary and Adrenal Gland: Implications for HPA System Regulation (2001)

Deficiency of corticotropin-releasing hormone receptor I (CRHR1) reduces anxiety-related behavior in mice and severely impairs the stress response of the hypothalamic-pituitary-adrenocortical (HPA) system. Most recently, we could show that severe emotional stressors induce a significant rise in plasma ACTH even in mice deficient for the CRHR1 (Crhr1-1-) which is, however, not accompanied by an increase in plasma corticosterone concentration, suggesting that CRHR1 might be directly involved in the regulation of adrenal corticosterone release. We therefore used the Crhr1-1- mouse model to clarify the potential role of adrenal CRHR1 in the regulation of the HPA system and, in particular, of corticosterone secretion. In Crhr1-/- mice, intravenous ACTH administration failed to stimulate corticosterone secretion despite a significant upregulation of ACTH receptor mRNA levels in the adrenal cortex of these mutants. Further, by means of RT-PCR and in situ hybridization analyses, we could provide first evidence that both CRHR1 and CRHR2 are expressed in the mouse pituitary and adrenal cortex. Stimulation of pituitary CRHR2 does not induce ACTH secretion either in vitro or in vivo. Our data strongly suggest that CRHR1 plays a crucial role in the release of corticosterone from the adrenal cortex, independently of pituitary function. The existence of an intra-adrenal CRH/CRHR1 regulatory system which contributes to the corticosteroid secretory activity adds to the complexity of HPA system regulation and stress hormone homeostasis.
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma (2016)

The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both tumor progression and tumor suppression. For example, while cells lacking PERK are sensitive to UPR-dependent cell death, acute activation of PERK triggers both apoptosis and cell cycle arrest, which would be expected to contribute tumor suppressive activity. We have evaluated these activities in the BRAF-dependent melanoma and provide evidence revealing a complex role for PERK in melanoma where a 50% reduction is permissive for BrafV600E-dependent transformation, while complete inhibition is tumor suppressive. Consistently, PERK mutants identified in human melanoma are hypomorphic with dominant inhibitory function. Strikingly, we demonstrate that small molecule PERK inhibitors exhibit single agent efficacy against BrafV600E-dependent tumors highlighting the clinical value of targeting PERK.
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities (2020)

The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and regulatory). Herein, we report the design and synthesis of three series of benzenesulfonamide-containing phenylalanine derivatives obtained by further structural modifications of <b>PF-74</b> to aid in the discovery of more potent and drug-like HIV-1 CA inhibitors. Structure-activity relationship studies of these compounds led to the identification of new phenylalanine derivatives with a piperazinone moiety, represented by compound <b>11l</b>, which exhibited anti-HIV-1<sub>NL4-3</sub> activity 5.78-fold better than <b>PF-74</b>. Interestingly, <b>11l</b> also showed anti-HIV-2<sub>ROD</sub> activity (EC<sub>50</sub> = 31 nM), with almost 120 times increased potency over <b>PF-74</b>. However, due to the higher significance of HIV-1 as compared to HIV-2 for the human population, this manuscript focuses on the mechanism of action of our compounds in the context of HIV-1. SPR studies on representative compounds confirmed CA as the binding target. The action stage determination assay demonstrated that these inhibitors exhibited antiviral activities with a dual-stage inhibition profile. The early-stage inhibitory activity of compound <b>11l</b> was 6.25 times more potent as compared to <b>PF-74</b> but appeared to work via the accelerating capsid core assembly rather than stabilization. However, the mechanism by which they exert their antiviral activity in the late stage appears to be the same as <b>PF-74</b> with less infectious HIV-1 virions produced in their presence, as judged p24 content studies. MD simulations provided the key rationale for the promising antiviral potency of <b>11l</b>. Additionally, <b>11l</b> exhibited a modest increase in HLM and human plasma metabolic stabilities as compared to <b>PF-74</b>, as well as a moderately improved pharmacokinetic profile, favorable oral bioavailability, and no acute toxicity. These studies provide insights and serve as a starting point for subsequent medicinal chemistry efforts in optimizing these promising HIV inhibitors.
16α-[125I]Iodo-11βMethoxy-17β-Estradiol:A Radiochemical Probe for Estrogen-Sensitive Tissues* (1986)

We have synthesized an analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodo-estra-1,3,5-(10)triene-3,17 beta-diol (16 alpha-iodo-11 beta-methoxyestradiol), as a potential radiopharmaceutical for the in vivo imaging of estrogen-sensitive tissues. This steroid was synthesized labeled with 125I by halogen exchange of the stable intermediate 11 beta-methoxy-16 beta-bromo-17 beta-estradiol with Na125I. The halogen exchange reaction produces the radioiodinated steroid with a 65-80% yield in 3 h. This rapid synthesis and purification of the 125I-labeled estrogen permits a similar synthesis with 123I, a radioisotope with excellent properties for imaging. The 11-methoxy analog is a highly potent estrogen that binds to the estrogen receptor with an affinity equal to that of estradiol. In vivo, 11 beta-methoxy-16 alpha-[125I]iodoestradiol concentrates in an estrogen receptor-dependent manner in the uterus, producing remarkably sustained and much higher uterus to blood ratios than 16 alpha-[125I]iodoestradiol. Thus, this radiosteroid shows great promise, both as a research probe of the estrogen receptor and as a clinical tool for the imaging of estrogen-responsive tumors.