gebhart/patrepeval huggingface dataset:
Bushing diagnosis using artificial intelligence and dissolved gas analysis (2008)

This dissertation is a study of artificial intelligence for diagnosing the condition of&#13;\nhigh voltage bushings. The techniques include neural networks, genetic algorithms,&#13;\nfuzzy set theory, particle swarm optimisation, multi-classifier systems, factor analysis,&#13;\nprincipal component analysis, multidimensional scaling, data-fusion techniques,&#13;\nautomatic relevance determination and autoencoders. The classification is done using&#13;\nDissolved Gas Analysis (DGA) data based on field experience together with&#13;\ncriteria from IEEEc57.104 and IEC60599. A review of current literature showed&#13;\nthat common methods for the diagnosis of bushings are: partial discharge, DGA,&#13;\ntan- (dielectric dissipation factor), water content in oil, dielectric strength of oil,&#13;\nacidity level (neutralisation value), visual analysis of sludge in suspension, colour of&#13;\nthe oil, furanic content, degree of polymerisation (DP), strength of the insulating&#13;\npaper, interfacial tension or oxygen content tests. All the methods have limitations&#13;\nin terms of time and accuracy in decision making. The fact that making decisions&#13;\nusing each of these methods individually is highly subjective, also the huge size of&#13;\nthe data base of historical data, as well as the loss of skills due to retirement of&#13;\nexperienced technical staff, highlights the need for an automated diagnosis tool that&#13;\nintegrates information from the many sensors and recalls the historical decisions and&#13;\nlearns from new information. Three classifiers that are compared in this analysis are&#13;\nradial basis functions (RBF), multiple layer perceptrons (MLP) and support vector&#13;\nmachines (SVM). In this work 60699 bushings were classified based on ten criteria.&#13;\nClassification was done based on a majority vote. The work proposes the application&#13;\nof neural networks with particle swarm optimisation (PSO) and genetic algorithms&#13;\n(GA) to compensate for missing data in classifying high voltage bushings. The work&#13;\nalso proposes the application of fuzzy set theory (FST) to diagnose the condition of&#13;\nhigh voltage bushings. The relevance and redundancy detection methods were able&#13;\nto prune the redundant measured variables and accurately diagnose the condition&#13;\nof the bushing with fewer variables. Experimental results from bushings that were&#13;\nevaluated in the field verified the simulations. The results of this work can help to&#13;\ndevelop real-time monitoring and decision making tools that combine information&#13;\nfrom chemical, electrical and mechanical measurements taken from bushings.
Data from Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity (2023)

&lt;div&gt;Abstract&lt;p&gt;The FGFR4/FGF19 signaling axis is overactivated in 20% of liver tumors and currently represents a promising targetable signaling mechanism in this cancer type. However, blocking FGFR4 or FGF19 has proven challenging due to its physiological role in suppressing bile acid synthesis which leads to increased toxic bile acid plasma levels upon FGFR4 inhibition. An FGFR4-targeting antibody, U3-1784, was generated in order to investigate its suitability as a cancer treatment without major side effects.&lt;/p&gt;&lt;p&gt;U3-1784 is a high-affinity fully human antibody that was obtained by phage display technology and specifically binds to FGFR4. The antibody inhibits cell signaling by competing with various FGFs for their FGFR4 binding site thereby inhibiting receptor activation and downstream signaling via FRS2 and Erk. The inhibitory effect on tumor growth was investigated in 10 different liver cancer models &lt;i&gt;in vivo&lt;/i&gt;. The antibody specifically slowed tumor growth of models overexpressing FGF19 by up to 90% whereas tumor growth of models not expressing FGF19 was unaffected. In cynomolgus monkeys, intravenous injection of U3-1784 caused elevated serum bile acid and liver enzyme levels indicating potential liver damage. These effects could be completely prevented by the concomitant oral treatment with the bile acid sequestrant colestyramine, which binds and eliminates bile acids in the gut. These results offer a new biomarker-driven treatment modality in liver cancer without toxicity and they suggest a general strategy for avoiding adverse events with FGFR4 inhibitors.&lt;/p&gt;&lt;/div&gt;
Experimental Demonstrations of Native Implementation of Boolean Logic Hamiltonian in a Superconducting Quantum Annealer (2021)

Experimental demonstrations of quantum annealing with “native” implementation of Boolean logic Hamiltonians are reported. As a superconducting integrated circuit, a problem Hamiltonian whose set of ground states is consistent with a given truth table is implemented for quantum annealing with no redundant qubits. As examples of the truth table, <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nand</small> and <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nor</small> are successfully fabricated as an identical circuit. Similarly, a native implementation of a multiplier comprising six superconducting flux qubits is also demonstrated. These native implementations of Hamiltonians consistent with Boolean logic provide an efficient and scalable way of applying annealing computation to so-called circuit satisfiability problems that aim to find a set of inputs consistent with a given output over any Boolean logic functions, especially those like factorization through a multiplier Hamiltonian. A proof-of-concept demonstration of a hybrid computing architecture for domain-specific quantum computing is described.
English studies in an Afrikaans University* (1964)

University studies in English are a comparatively recent introduction at English universities. Cambridge, for instance, first established a Chair of English in 1911. The comparable dates for certain other subjects are as follows: Mechanics, 1875; Physics, 1871; Zoology, 1866. Cambridge was, in fact, the last of the senior British uni­ versities to establish a Chair of English. Edinburgh, ap­ parently, was the first, with its Chair of Belles-Lettres which was an off-shoot of the Department of Logic. The need for this Chair arose partly from the replacement of Latin as the medium of instruction by English. Nowa­ days one often finds that the practical study of English as a means of communication is rejected on traditional grounds as unacademic. It is rather disconcerting to find that for the first 135 years of its existence the oldest University Department of English devoted its energies at least partly to what we would call "Practical English.”
Multiple Forms of Human y-Glutamyltransferase (1982)

Eight fractions of human γ-glutamyltransferase were prepared from liver tissue, serum and bile by gel filtration. Bile, pooled serum from patients with high γ-glutamyltransferase activities and serum in which liver tissue had been incubated, each contained an enzyme fraction with molecular weight greater than 10^6. A fraction of about 80,000 molecular weight was obtained from bile, and by incubation of liver tissue in serum or sodium chloride solution, but not from the serum pool. The main enzyme fraction in native serum had a molecular weight of about 300,000, and the molecular weight of γ-glutamyltransferase partially purified from liver was initially 160,000. The fractions had similar K(m) and K(1) values, and differences in heat stability and binding to concanavalin A were not marked.
The effect of dry heat on the ME7 strain of mouse-passaged scrapie agent (1996)

Partial survival of lyophilized scrapie agent has been reported previously following exposure to dry heat at 360 degrees C for 1 h, and led to speculation that scrapie-like agents might not be completely inactivated by incineration. However, it is known that dried infectivity is more difficult to inactivate by heat than that in hydrated samples. In this present study it was shown that the infectivity in macerates of mouse-brain infected with the ME7 strain of scrapie agent was not completely inactivated by exposure to dry heat at temperatures up to 180 degrees C for 1 h but the titre of surviving infectivity reduced progressively as the temperature was increased. No infectivity was recovered after a 1 h exposure at 200 degrees C. These data suggest that scrapie-like agents are unlikely to survive incineration.
Use of intravesical capsaicin for urge urinary incontinence and irritative voiding syndromes (1998)

Intravesical capsaicin has been used in the management of selected patients with urge urinary incontinence throughout this decade, but the past 12 months has seen considerable interest in this and related compounds. It is no coincidence that during the same period the capsaicin receptor was cloned and named the vanilloid receptor subtype 1 and the European dual centre study of intravesical capsaicin reported that overall 80% of patients derived some clinical benefit. In spite of this, ultrapotent capsaicin analogues such as resiniferatoxin, which also interact with the vanilloid receptor subtype 1, are being studied. Preliminary reports of the potential advantages of intravesical resiniferatoxin are beginning to emerge, and in the future drugs that manipulate the vanilloid receptor may become universally important in the management of neurogenic overactive bladders.
Application of Bacillus subtilis to the Roots of Leafy Greens, in the Presence of Listeria innocua and Salmonella Newport, Induces Closure of Stomata (2015)

Plant growth-promoting rhizobacterium Bacillus subtilis UD1022 has been shown to trigger an induced systemic response in Arabidopsis thaliana. This interaction causes plant stomata to close, protecting the plant from infection by plant pathogens and thereby increasing crop yield. The purpose of this study was to determine whether UD1022 applied to the roots of plants is able to induce stomata closure in leafy greens as well as influence the persistence of human pathogens (Listeria and Salmonella) on plants. UD1022 induced stomata closure in the presence of human pathogens on both lettuce and spinach 3 h post-inoculation (p<0.0001). Results were confirmed by root inoculation with heat-killed UD1022, which did not induce stomata closure. Presence of UD1022 on lettuce roots significantly reduced the persistence of Listeria on plants after 3 days post-inoculation (p=0.02) but had less of an effect on the persistence of Salmonella. The results of this study indicate that plant growth-promoting rhizobacterium B. subtilis UD1022 may be able to prevent contamination by some human pathogens. This is the first study to investigate the use of plant growth-promoting rhizobacteria to control the persistence of human pathogens on plants.
Advances in Catalysis and Related Subjects (1959)

Since 1948, this Series has filled the gap between the papers that report and the textbooks that teach in the diverse areas of catalysis research. The editors of and contributors to Advances in Catalysis are dedicated to recording progress in this area. Each volume of Advances in Catalysis contains articles covering a subject of broad interest.
In vivo wear of enamel by a lithia disilicate-based core ceramic used for posterior fixed partial dentures: first-year results. (2006)

Further analysis with a larger sample size is needed to determine the relationship between occlusal clenching force and wear rate and the influence of other factors that cause increased wear of enamel by opposing ceramic restorations.
HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model (2018)

Streptozotocin (STZ) acts specifically on pancreatic beta cells, inducing cell destruction and cell dysfunction, resulting in diabetes. Many studies have reported that nuclear factor-erythroid 2-related factor 2 (Nrf2), a main regulator of antioxidant expression, prevents and improves diabetes-related diseases. In this study, we investigated the antidiabetic effect of the newly discovered Nrf2 activator, HX-1171, in the STZ-induced diabetic mouse model. HX-1171 enhanced insulin secretion by reducing STZ-induced cell apoptosis, and decreased intracellular reactive oxygen species (ROS) generation by upregulating the expression of antioxidant enzymes through Nrf2 activation in INS-1 pancreatic beta cells. In STZ-induced diabetic mice, HX-1171 administration significantly lowered blood glucose levels and restored blood insulin levels. In the STZ-only injected mice, the pancreatic islets showed morphological changes and loss of function, whereas the HX-1171-treated group was similar to that of the control group. These results suggest that HX-1171 may be developed as a promising therapeutic agent for diabetes-related diseases.
Use of the in Vivo Hollow Fiber Assay in Natural Products Anticancer Drug Discovery (2009)

The in vivo hollow fiber assay was developed at the National Cancer Institute (NCI) to help bridge the gap between in vitro cell-based assays and human tumor models propagated in immunodeficient mice. The goal was to develop an intermediate assay that could help predict which compounds found active in the 60-cell line panel would be active in a subsequent xenograft system. This was necessary due to the high cost of the traditional xenograft assay in terms of number of animals required, time for assay completion, and financial commitment necessary. To address this problem, investigators of the NCI Developmental Therapeutics Program designed a method of propagating human cancer cells in inert hollow fibers with pores small enough to retain the cancer cells but large enough to permit entry of potential chemotherapeutic drugs, including large proteins and other important substances. Fibers containing proliferating cancer cells are transplanted into the peritoneum or under the skin, the host mice are treated with a test agent, and the fibers are subsequently retrieved for analysis of viable cell mass. The assay has been successful in helping investigators from around the world, including our own research group, prioritize compounds active in vitro for further testing in the traditional xenograft system.
Magnetite Dissolution and Crevice Studies with Chelant Solutions (1982)

Work is described in two related areas: (a) fundamental studies of the dissolution behavior of synthetic magnetite in aqueous chelant solutions as functions of solution pH, temperature, heating time, chelant structure, and the presence of additives, and (b) more applied investigations in which information from the basic studies was utilized in choosing solutions and experimental conditions for the removal of magnetitebased corrosion products from simulated steam generator tube-tube support plate crevices.The magnetite dissolution work has employed a novel, convenient, and sensitive experimental technique based on the ferromagnetism characteristic of Fe3O4. Since chemical reaction of magnetite with chelants results in nonmagnetic iron chelates, monitoring the ferromagnetism of a reaction mixture, as a whole, provides an in situ and quantitative measure of unconsumed magnetite.
An Abiotic Model for Stromatolite Morphogenesis : ABSTRACTS (1997)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Poster on "Exception handling in ADOME workflow management system" (1997)

Summary form only given. The paper discusses exception handling in ADOME workflow management system (WMS). ADOME (Advanced Object Modeling Environment) is an active OODBMS extended with role facilities, built by integrating ITASCA (OODB) and CLIPS (inference engine). It provides a good supporting environment for the dynamic features required for a workflow management system, especially for online exception handling. In ADOME-WFMS, exception handlers can be procedural (extra branches of existing activity decomposition for exception handling) or declarative (in the form of ECA rules that can be specified within the scope of different activity and sub-activity levels).
Single-Phase Cryogenic Flows Through Microchannel Heat Sinks (2014)

Cryogenic fluids are used widely in several thermal management applications such as in regenerative cooling of rocket engine combustor liners, missile warning receivers, satellite tracking systems and cryo-adsorbent hydrogen storage systems. Single phase laminar flow and heat transfer rate of liquid nitrogen in microchannels is studied experimentally in this paper. The performance of two distinct geometries of microchannel heat sinks are evaluated and compared for simultaneous developing laminar flow in the Reynolds number range from 180 to 610. The first geometry pertains to parallel microchannels while the second corresponds to a staggered microscale pin fin array. Two parallel microchannel geometries having identical widths of 140μm and identical laminar thermal resistances but with different aspect ratios of 4.7 and 7.6 are compared. The pin fin heat sink consisted of square pins of 395μm side and oriented at 45 degrees to the flow. All three heat sinks have identical heat source surface area. Results are presented in a non-dimensional form in terms of the friction factor, Nusselt, Reynolds numbers and compared with the predictions of existing correlations in the literature for parallel microchannels and micro pin fin heat sinks.
Optical Switching of IP Traffic Using Input Buffered Architectures (2002)

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Interferon-γ activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells (2005)

NADPH oxidase 1 (Nox1), a homolog of gp91(phox), is dominantly expressed in large intestinal epithelium, and reactive oxygen species derived from Nox1 are suggested to serve a role in host defense. We report that interferon (IFN)-gamma, a crucial transactivator of the gp91(phox) gene, also stimulates expression of Nox1 mRNA and protein in large intestinal epithelium (T84 cells), leading to fourfold upregulation of superoxide anion (O(2)(-)) generation. Introduction of small interfering Nox1 RNA completely blocked this priming. We cloned the region from -4,831 to +195 bp of the human Nox1 gene. To reveal IFN-gamma-responsive cis elements, we performed transient expression assays using a reporter gene driven by serially truncated Nox1 promoters in T84 cells. IFN-gamma-responsive elements were located between -4.3 and -2.6 kb, and one gamma-activated sequence (GAS) element present at -3,818 to -3,810 bp exhibited this IFN-gamma-dependent promoter activity. IFN-gamma caused tyrosine phosphorylation of signal transducer and activator of transcription 1 (STAT1) and produced a protein-GAS complex that was recognized by anti-STAT1 antibody. The introduction of three-point mutation of GAS, which did not interact with STAT1, completely canceled the IFN-gamma-dependent promoter activity of the region from -4,831 to +195 bp. A Janus protein tyrosine kinase 2 inhibitor (AG490) blocked the IFN-gamma-stimulated tyrosine phosphorylation of STAT1, promoter activity of the -4,831 to +195 bp region, Nox1 mRNA expression, and O(2)(-) production, also suggesting a crucial role of STAT1 and GAS in the IFN-gamma-stimulated transcription of the Nox1 gene. Our results support a potential contribution of Nox1 to mucosal host defense and inflammation in the colon.
Air Flow Modeling in a Mechanically Ventilated Room (2008)

Optimum values of temperature and air flow velocity are desirable in a room for human comfort. Mechanical ventilation is an effective method to achieve this. These variables are affected by many parameters. The location of the inlet and the outlet duct play a pivotal role. This work aims at the numerical modeling of the room air flow phenomena when the inlet and outlet are placed at different locations in the room. Computational Fluid Dynamic (CFD) modeling of the air flow distribution is carried out in a mechanically ventilated enclosure that represents the scaled down model of a room. Turbulent regime of air flow is analyzed. RNG k-e model is used to model the turbulent flow. Also, this work aims at suggesting the most ideal ventilation, which would provide comfortable room environment in winter season in coastal India. Commercial CFD package, FLUENT is used for the modeling of the various phenomena.
Implications of thermal sensitivity of the static internal friction angle (2009)

Thermal variability of the coefficient of the critical state, or the angle of internal friction is examined in view of experimental results obtained for clays and hard rocks. This sensitivity has several implications for the evolution of what is considered as apparent preconsolidation pressure in constant stress heating tests. Failure conditions in soils at elevated temperatures appear to be strongly dependent on the history of application of stress and temperature, and hence are affected by the thermal sensitivity of the internal friction angle. Consequences to ranges of admissible processes are discussed.
Factors Affecting the Collaboration in Supply Chain of Mechanical Enterprises in Vietnam (2015)

In the context of international economic integration, enterprises need to participate in the global supply chain to take advantage of assets, talents and other capability. Base on the Structure Equation Model (SEM-PLS) using primary data collected from 205 mechanical enterprises in Vietnam, the research result shows that there are nine direct factors affecting the collaboration in supply chain including: (i) trust; (ii) power; (iii) maturity; (iv) frequency; (v) distance; (vi) culture; (vii) strategy; (viii) policy; (ix) commitment. Results of the research give strong evidences for policy makers and enterprises for management the supply chain collaboration in mechanical sector in particular and other sectors in general as well as its contribution to literature review of supply chain management.