gebhart/patrepeval huggingface dataset:
Emotion Recognition in the Wild via Convolutional Neural Networks and Mapped Binary Patterns (2015)

We present a novel method for classifying emotions from static facial images. Our approach leverages on the recent success of Convolutional Neural Networks (CNN) on face recognition problems. Unlike the settings often assumed there, far less labeled data is typically available for training emotion classification systems. Our method is therefore designed with the goal of simplifying the problem domain by removing confounding factors from the input images, with an emphasis on image illumination variations. This, in an effort to reduce the amount of data required to effectively train deep CNN models. To this end, we propose novel transformations of image intensities to 3D spaces, designed to be invariant to monotonic photometric transformations. These are applied to CASIA Webface images which are then used to train an ensemble of multiple architecture CNNs on multiple representations. Each model is then fine-tuned with limited emotion labeled training data to obtain final classification models. Our method was tested on the Emotion Recognition in the Wild Challenge (EmotiW 2015), Static Facial Expression Recognition sub-challenge (SFEW) and shown to provide a substantial, 15.36% improvement over baseline results (40% gain in performance).
1670: A New Approach for Predicting the Chemosensitivity of Human Cancers and its Application to Drug Discovery (2007)

You have accessJournal of UrologyPodium 46, Tuesday, May 22, 2007, 3:30 - 5:30 pm1 Apr 20071670: A New Approach for Predicting the Chemosensitivity of Human Cancers and its Application to Drug Discovery Jae Lee and Dan Theodorescu Jae LeeJae Lee More articles by this author and Dan TheodorescuDan Theodorescu More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31858-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1670: A New Approach for Predicting the Chemosensitivity of Human Cancers and its Application to Drug Discovery." The Journal of Urology, 177(4S), p. 554 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 554 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jae Lee More articles by this author Dan Theodorescu More articles by this author Expand All Advertisement PDF downloadLoading ...
Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells (2005)

Cyclin-dependent kinase 6 (CDK6) binds to and is activated by cyclin D1 and thereby enhances the transition of cells through the G1 phase of the cell cycle. The present study indicates that, in human prostate cancer cells, CDK6 can also bind to the androgen receptor (AR) and stimulate its transcriptional activity in the presence of dihydrotestosterone. This effect of CDK6 does not require its kinase activity and is inhibited by cyclin D1 and p16INK4a. The T877A mutant of the AR frequently found in advanced cases of prostate cancer displays an exaggerated stimulation of transcriptional activity by CDK6. Androgen-sensitive LNCaP prostate cancer cells engineered to stably overexpress CDK6 display increased expression of the prostate-specific antigen and enhanced growth in the presence of dihydrotestosterone. CDK6 is present in the chromatin structure of these cells in association with the AR and the promoter region of the prostate-specific antigen gene. These findings suggest that CDK6 may play an important role in the development and/or progression of a subset of human prostate cancers by stimulating the activity of the AR.
Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition (2012)

The total synthesis of 16 new ion channel inhibitors derived from noricumazole A, a secondary metabolite from the myxobacterium Sorangium cellulosum, is reported. Particular focus of library design is put on stereochemical permutations in the central region (C9 and C11), the oxazole moiety and the side chain at C4 of the isochromanone moiety. Noricumazole A and all new noricumazole derivatives were tested in an assay system with inhibitory effect on the hepatitis C virus (HCV) life cycle. Most of them are moderate to strong HCV inhibitors (350 nM-6 nM) but also exert pronounced cytotoxicity. In contrast, the thiazole analogue of noricumazole A is a strong HCV inhibitor with only moderate cytotoxic property. It may become a lead structure with a good therapeutic index (CC(50)/IC(50)) of greater than 10.
Automatic adjustment system for the multipass eight-channel power module of a megajoule laser (2018)

This paper presents the optical layout and composition of a system for automatically adjusting the multipass power module of a next-generation laser apparatus. An adjustment technique based on near-field and far-field markers is described. A control program under the Astra Linux operating system is described for the automatic-adjustment system.
Optimization of voltage axis alignment in high-resolution electron microscopy (1999)

An improved method for optimizing the voltage axis alignment is proposed. This method is based on averaging of the through-focus images by vibrating the accelerating-voltage rapidly, referred to as Häusler-type focal-depth extension processing. The voltage-centre axis alignment was achieved within a 0.2 mrad accuracy in real-time by establishing the condition based on the vanishing of the contrast of the focus-averaged image.
NetEx (2010)

The Internet is witnessing explosive growth in traffic due to bulk content transfers, such as multimedia and software downloads, and online sharing of personal, commercial, and scientific data. Yet bulk data transfers remain very expensive and inefficient. As a result, huge amounts of digital data continue to be delivered outside of the Internet using hard drives, optical media or tapes. Meanwhile, large reserves of spare bandwidth lie unutilized in today's networks, where links are overprovisioned for peak load. We designed NetEx, a bulk transfer system that opportunistically exploits the excess capacities of network links to deliver bulk content cheaply and efficiently. Our results based on data from both a commercial tier-1 ISP and the Abilene network suggest that NetEx can considerably increase the capacity of the network, and at the same time it can provide good average performance to bulk transfers.
CALVAL EVALUATION OF DESIS PRODUCTS IN AMIAZ PLAIN AND MAKHTESH RAMON TEST SITES, SOUTHERN ISRAEL (2022)

Abstract. The new era of hyperspectral remote (HSR) sensors in orbit is approaching. Missions such as CHIME of the European Space Agency (ESA), EMIT/SBG of NASA, EnMAP of the German Aerospace Center (DLR), and SHALOM of the Israel Space Agency (ISA) will launch in the near future, while other HSR sensors are already in orbit, such as DESIS of DLR, PRISMA of the Italian Space Agency (ASI), and HISUI of the Japan Aerospace Exploration Agency (JAXA). Vicarious calibration (VC) of satellite sensors is vital to tracking a sensor's performance during its lifetime and is a routine procedure in any satellite mission. Accordingly, searching for ideal sites for CAL/VAL operation is an important task that should be part of the mission planning. This study demonstrates two areas in southern Israel that can be acquired in one overpass as VC sites: Amiaz Plain (AP) and Makhtesh Ramon (MR), which were evaluated for their fulfillment of all VC requirements for HSR sensors. AP (5 km2 of homogeneous bright target) was found suitable for radiometric calibration, and MR (200 km2) for spectral and thematic validations. We checked the applicability of these sites using a high-end airborne HRS sensor (AisaFENIX 1K sensor with 420 bands, 375–2500 nm spectral range, and 1.5-m spatial resolution) along with comprehensive field studies and ground measurements. Accordingly, we developed an operational VC protocol to use these sites for both radiometric and spectral quality inspection of HRS satellites. We demonstrated this capability on recent PRISMA and DESIS reflectance products. Here we provide these analyses and recommend how to use these areas to further examine DESIS data's performance. We call for collaborations with individuals and space agencies in using these VC sites, where we will provide ground-truth information and fulfill any other requirements for VC.
Abstract A39: Characterizing the epigenetic effects of the histone 3.3 G34W mutation in giant cell tumors of bone (2018)

Abstract Introduction: Pediatric glioblastomas (pGBM) are malignant brain tumors associated with a dismal prognosis. A subset of pGBMs carry mutations of either the Lysine 27 or Glycine 34 (G34) amino acid residues of histone 3 variant genes. The same G34 residue is also mutated in 85-95% of giant cell tumors of bone (GCTs), albeit to Tryptophan (G34W) in GCTs rather than to Arginine or Valine (G34R/V) as in pGBMs. The G34 mutation is predicted to impede access of histone methyltransferases like SetD2 to the nearby Lysine 36 residue, thereby altering the epigenome and transcriptome. Methods: To elucidate the tumorigenic effect of G34 mutations, we used the gene-editing technology CRISPR/Cas9 to correct the G34W mutation to wild-type in 2 GCT cell lines. We then investigated CRISPR-edited cell lines using functional assays, proteomic, epigenomic, and transcriptomic analyses. Results: Correction of the G34W mutation to wild-type in CRISPR-edited GCT cells results in phenotypic and functional changes suggestive of reduced tumorigenicity. By mass spectrometry, G34W-mutant GCT cell lines display decreased level of Lysine 36 trimethylation (H3K36me3) on the mutant G34-peptide, similar to G34-mutated pGBM cell lines. However, unlike pGBMs, GCTs display increased levels of Lysine 36 dimethylation (H3K36me2) on the mutant G34W-peptide. Ongoing Experiments and Analyses: We are currently comparing the level and distribution of multiple histone marks by performing chromatin immunoprecipitation followed by next-generation sequencing (ChIP-Seq) of CRISPR-edited wild-type clones relative to the parent G34W-mutant GCT line. We are also assessing differential gene expression by RNA-Seq and characterizing the methylation signature by 850K DNA methylation array of G34W-mutant GCTs and edited clones. Conclusion: The G34W-mutation clearly has an impact on tumorigenic potential, as evidenced by in vitro functional assays. The G34W-mutant peptide of GCT cell lines features a distinct profile of post-translational histone modifications compared to G34R- or G34V-mutant peptides of pGBM cell lines. Further investigation could elucidate the epigenetic mechanism(s) through which the G34W mutation confers its tumorigenic properties. Citation Format: Shriya Deshmukh, Sima Khazaei, Dylan Marchione, Ashot Harutyunyan, Benjamin Garcia, Nada Jabado. Characterizing the epigenetic effects of the histone 3.3 G34W mutation in giant cell tumors of bone [abstract]. In: Proceedings of the AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; 2017 Dec 3-6; Atlanta, Georgia. Philadelphia (PA): AACR; Cancer Res 2018;78(19 Suppl):Abstract nr A39.
An Experimental Basis for the Estimation of Auditory System Hazard Following Exposure to Impulse Noise (1992)

The energy spectrum of a noise is known to be an important effects of a traumatic exposure. However, existing criteria for exposure to impulse noise do not consider the frequency spectrum of an impulse as a variable in the evaluation of the hazards to the auditory system. This report presents the results of three studies that were designed to determine the relative potential that impulsive energy has in causing auditory system trauma. Four hundred and seventy five (475) chinchilla were used in these experiments. Pre- and post- exposure hearing thresholds were measured on each subject. In the first study, the noise exposure stimuli consisted of six different computer-generated narrow band tone bursts having center frequencies located at 0.260, 0.775, 1.025, 1. 350, 2.450, and 3.550 kHz. Each narrow band exposure stimulus was presented at two to four different intensities. An analysis of the audiometric data allowed a frequency weighting function to be derived. This weighting function de- emphasizes low frequency energy more than the conventional A-weighting function. In the second study, the exposures consisted of two--types of broad band computer synthesized impulses. Subjects were exposed to 100 impulses at a rate of 1-per-3-seconds. Each type of impulse was presented at 3 intensities. The third study used impulses generated by three different diameter shock tubes. Subjects were exposed to 1, 10, or 100 impulses at one of three intensities. The results of the second and third studies were interpreted using the weighting' function derived from the first study. The hearing loss from all three studies is a linear function of the weighted SEL calculated using the weighting function, derived in the first study. Impulse noise, Hearing, Chinchilla, Audiometry and histology.
Auf verschlungenen Pfaden zur Pluripotenz (Nobel‐Aufsatz) (2013)

In somatischen Zellen kann durch verstärkte Expression bestimmter Transkriptionsfaktoren Pluripotenz induziert werden. Auf dieser Grundlage wurden effektive Reprogrammierungsverfahren zur Generierung von induzierten pluripotenten Stammzellen (iPS-Zellen) erforscht und entwickelt. S. Yamanaka erhielt für diese Forschungen den Medizin-Nobelpreis 2012.
Resource allocation for device-to-device communication overlaying two-way cellular networks (2013)

In this paper, a spectrum sharing protocol is proposed for device-to-device (D2D) communication overlaying cellular networks. Specifically, the protocol allows the D2D users to communicate bi-directionally with each other while assisting the two-way communication between the cellular base station (BS) and the cellular user (CU) over the same time and frequency resources. The achievable rate region of the sum-rate of the D2D transmissions versus that of the cellular transmissions is evaluated. The Pareto boundary of the region is found by optimizing the transmit power at BS and CU as well as the power splitting factor at the relay D2D node. We find through numerical results that the proposed two-way protocol with power control at the BS and CU is effective to improve the sum rate for both the D2D and cellular communication.
Characterization of the cutting edge of glass and diamond knives for ultramicrotomy by scanning force microscopy using cantilevers with a defined tip geometry. Part II (2003)

The cutting edge of glass as well as diamond knives was studied at high resolution using a scanning force microscope (SFM). The local shape of the cutting edge was estimated from single line profiles of the SFM topographs taking into account the exact shape of the probing tip estimated by a high-resolution field emission scanning electron microscope (FESEM). The glass knives were prepared by 'balanced breaking'. The radius of the investigated cutting edges was found to be 3.2-4.4 nm and 4.3-6.0 nm for the 35 degrees and 45 degrees diamond knife, respectively, and 3.4-4.3 nm for the glass knives. Besides the opening angle and the cutting edge radius, the friction of a knife during sectioning represents a significant factor influencing the quality of sections. Thus, the roughness of both the diamond clearance angle side and the back side was characterized as well. Corresponding RMS values of the roughness were found to be smaller on the back side (approximately 0.14 nm) than on the clearance angle side (approximately 0.26 nm).
Enhanced nuclear factor-κB activation induced by tumour necrosis factor-α in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein (1996)

This study demonstrates that the enhanced NF-kappa B activation exhibited by stably tat-transfected cells in response to TNF-alpha, is associated with cell surface interaction of extracellularly released Tat protein. These data add further evidence to the possible relevance of a Tat autocrinous loop in the physiology of Tat-producing cells and suggest that in HIV-1-infected cells Tat is likely to behave as a bifunctional molecule which not only acts from within facilitating NF-kappa B recruitment in the viral transcription complex, but may also act from without increasing the availability of activated NF-kappa B.
Fast-Grown Interpenetrating Network in Poly(3-hexylthiophene): Methanofullerenes Solar Cells Processed with Additive (2009)

With the aim of revealing the role of additives in polymer solar cells, different amounts of 1,8-octanedithiol (OT) were added to the poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl C61-butyric acid methyl ester (PCBM) blend system in order to observe the transition between systems with and without additive. We found that highly efficient P3HT:PCBM networks can be formed in the very early stage of the spin-coating process when a small amount of additive was added. The carrier mobilities of this fast-grown network were found to be comparable with those processed with solvent annealing. As a result, short circuit current density (Jsc) as high as ∼9 mA cm−2 can be obtained and the fill factor (FF) can reach ∼62%. The power conversion efficiency (PCE), however, is limited by the low open circuit voltage (Voc) of the devices processed with OT. According to the grazing incidence X-ray diffraction data, a much shorter interlayer spacing (d(100) ∼ 15.6−15.7 Å) compared with those processed with different methods is observed in the polymer blends processed with OT, which is likely the reason for the low Voc.
merAligner: A Fully Parallel Sequence Aligner (2015)

Aligning a set of query sequences to a set of target sequences is an important task in bioinformatics. In this work we present merAligner, a highly parallel sequence aligner that implements a seed -- and -- extend algorithm and employs parallelism in all of its components. MerAligner relies on a high performance distributed hash table (seed index) and uses one-sided communication capabilities of the Unified Parallel C to facilitate a fine-grained parallelism. We leverage communication optimizations at the construction of the distributed hash table and software caching schemes to reduce communication during the aligning phase. Additionally, merAligner preprocesses the target sequences to extract properties enabling exact sequence matching with minimal communication. Finally, we efficiently parallelize the I/O intensive phases and implement an effective load balancing scheme. Results show that merAligner exhibits efficient scaling up to thousands of cores on a Cray XC30 supercomputer using real human and wheat genome data while significantly outperforming existing parallel alignment tools.
Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling (2020)

Reactive oxygen species (ROS) is major risk factor in neuronal diseases including ischemia. Although biliverdin reductase A (BLVRA) plays a pivotal role in cell survival via its antioxidant function, its role in hippocampal neuronal (HT-22) cells and animal ischemic injury is not clearly understood yet. In this study, the effects of transducible fusion protein Tat-BLVRA on H<sub>2</sub>O<sub>2</sub>-induced HT-22 cell death and in an animal ischemia model were investigated. Transduced Tat-BLVRA markedly inhibited cell death, DNA fragmentation, and generation of ROS. Transduced Tat-BLVRA inhibited the apoptosis and mitogen activated protein kinase (MAPK) signaling pathway and it passed through the blood-brain barrier (BBB) and significantly prevented hippocampal cell death in an ischemic model. These results suggest that Tat-BLVRA provides a possibility as a therapeutic molecule for ischemia.
<title>Synthesis Of Nonlinear Non-Monotonic Functions In Optical Image Processing</title> (1976)

When halftone screens are used to realize monotonic or non-monotonic nonlinear point transfer functions in a coherent optical system, the screens are usually composed of periodically repeated cells which are themselves monotonic in density. This is not necessary, and an algorithm for generating non-monotonic cells yielding a desired transfer function in the first diffraction order is described. In practice, the photographic operations are non-ideal and change the nonlinear characteristics from input to output. The effects of low film gamma and low film saturation density can be calculated, and, to some extent, compensated a priori.
Intracerebroventricular Infusion of Angiotensin-(1–7) Ameliorates Cognitive Impairment and Memory Dysfunction in a Mouse Model of Alzheimer’s Disease (2016)

This work was performed to test our hypothesis that angiotensin-(1-7) can ameliorate cognitive impairment and cerebrovascular reactivity in 5XFAD mice, a useful model of Alzheimer's disease. 5XFAD mice received intracerebroventricular infusion of (1) vehicle, (2) angiotensin-(1-7), or (3) angiotensin-(1-7)+A779, a specific Mas receptor antagonist, for 4 weeks. Angiotensin-(1-7), through Mas receptor, significantly ameliorated cognitive impairment in 5XFAD mice. As estimated by acetazolamide-induced increase in cerebral blood flow, angiotensin-(1-7), through Mas receptor, enhanced cerebrovascular reactivity in 5XFAD mice. In conclusion, angiotensin-(1-7)/Mas receptor axis improves cognitive function and cerebrovascular function in a mouse model of Alzheimer's disease.
Analytical and Numerical Studies of a Differential Target Antenna Coupling Method for Sensing and Imaging Subsurface Targets (2013)

Abstract In this paper, we develop the theoretical basis and carry out numerical studies on a new Differential Target Antenna Coupling (DTAC) method for imaging objects within the earth. The DTAC method uses a separate transmitter and a rotating receiver to collect the magnetic field data. The DTAC method uses at least two frequencies. One frequency is used as a reference signal to establish the null direction at that frequency, and then a different frequency is used to measure the change in the null at that new frequency. We can also use an arbitrary number of frequencies with just one reference frequency for wide-bandwidth measurements. By comparing the characteristics of the null magnetic fields at these two or more frequencies, this technique allows one to precisely determine the orientations of the measuring array from the measured data. This allows for the nulling out of the overwhelming effects of the layered earth, thereby allowing for the measurement of the much smaller target response. In this paper, we have assumed a horizontal array with an intended separation between transmitter and receiver of the order of kilometers and a very powerful transmitter. The depth of investigation in this case was also of the order of kilometers. This type of array is applicable to natural resource investigations, e.g., mining, geothermal, and petroleum.