gebhart/patrepeval huggingface dataset:
Studies on the profile of desmethylimipramine as a gastric antisecretory agent (1982)

Abstract Desmethylimipramine (DMI) and atropine were compared in a variety of organ system tests in rats involving parasympathetic function in order to evaluate the specificity of these compounds as gastric antisecretory agents. DMI was similar to atropine in its effects on the stomach; each markedly inhibited gastric acid secretion and stomach emptying and protected against restraint‐induced gastric ulceration. However, unlike atropine, DMI did not substantially increase pupil size, reduce fecal pellet output, cause urinary retention, or increase heart rate. From these data, it is possible that at least certain antidepressant type drugs could be developed for the treatment of peptic ulcer disease.
Development of near-field emission limit from radiated-emission limit based on statistical approach (2012)

This paper discusses a novel approach to transforming a radiated-emission limit (e.g., CISPR 22 and FCC) from the far-field to the near-field region. The proposed approach combines data from a near-field scanner and a gigahertz transverse electromagnetic cell with statistics to establish a simple relationship between a near-field magnetic field and a far-field electric field. It is shown that the proposed approach has the potential to be a simple, quick, and fairly inexpensive tool for electromagnetic compatibility pre-compliance purposes.
The Research of a Multi-Factor Dynamic Authorization Model (2012)

As there are always changes in trust level, organization structure, attributes of the subject, time strategy and so on, which will cause subject pemissions' change. The traditional static authorization based access control model is not appropriate in this condition. In this paper, a model which can support dynamic authorization according to these changes is discussed. This model not only has strong ability to describe the requirements from users and application systems, but also has enough flexibility to capture the changes of subject's attribute, organization structure, trust value, time strategy, and based on these to do dynamic authorization.
Writer Identification of Arabic Handwritten Digits (2011)

This paper addresses the identification of Arabic handwritten digits. In addition to digit identifiability, the paper presents digit recognition. The digit image is divided into grids based on the distribution of the black pixels in the image. Several types of features are extracted (viz. gradient, curvature, density, horizontal and vertical run lengths, stroke, and concavity features) from the grid segments. K-Nearest Neighbor and Nearest Mean classifiers are used. A database of 70000 of Arabic handwritten digit samples written by 700 writers is used in the analysis and experimentations. The identifiability of isolated and combined digits are tested. The analysis of the results indicates that Arabic digits 3 (٣), 4 (٤), 8 (٨), and 9 (٩) are more identifiable than other digits while Arabic digit 0 (٠) and 1 (١) are the least identifiable. In addition, the paper shows that combining the writer’s digits increases the discriminability power of Arabic handwritten digits. Combining the features of all digits, K-NN provided the best accuracy in text-independent writer identification with top-1 result of 88.14%, top-5 result of 94.81%, and top-10 results of 96.48%.
Experimental Observation of Ultrafast THz Absorption Modulation in a Graphene-Based Metasurface (2019)

Graphene, a two-dimensional material made of carbon atoms arranged in a honeycomb lattice, has attracted enormous attention since its experimental realization in 2004 due to its unique mechanical, thermal, electrical and optical properties. Particularly in the THz spectrum, graphene predominantly exhibits a Drude-like response due to its easily generated and controlled free carriers and therefore is considered a suitable platform for dynamically tunable metasurface components. Such an example, are the so called thin film absorbers that are structures capable of absorbing all power of incident electromagnetic waves. They are used as non-reflective covering layers for shielding against electromagnetic radiation and minimization of backscattering from electromagnetic large structures. Within the concept of metasurfaces, thin film absorbers, are usually implemented by placing a lossy material on the top of a perfectly conducting metallic plate. Recently, an electrostatic gate-tunable perfect absorber based on a monolayer graphene over a grounded dielectric was demonstrated experimentally in the low THz regime. Nevertheless, the dynamic control of the absorption properties of such devices in an ultrafast way still remains a challenge.
Affinity based VM Migration: A Case Study based on resource nonavailability on Host (2018)

Using virtualization many Virtual Machines can run simultaneously on the same Host. For dynamic resource management, virtual machines can be migrated from residing host to a different. But before starting the migration some questions need to be answered like when to start the virtual machine migration, which VM to migrated and where? The Virtual Machine migration techniques on the Virtual cloud environment has already been researched at length, but very few studies have focused on affinity-relations among virtual machines during migration, hence the key objective of this research paper, is to explore the Affinity-aware VM migration in detail and propose Affinity-Aware VM migration algorithms for migration of a group of VMs with affinity to a destination Host with less capacity than required. This paper also provides a brief review of several virtual machine migration techniques.
Regiospecific Nucleophilic Substitution of Fluorine in Fused Tetrafluoroquinolines with N‐ and O‐Nucleophiles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Frequency and directional selectivity in primary auditory afferents in fishes (2002)

Coding of frequency and particle motion directionality is described for two fishes; goldfish (a sound-pressure specialist), and oyster toadfish (a hearing generalist). The goldfish hears in a wide bandwidth (&amp;gt;2 kHz) and the toadfish in a narrower one (&amp;lt;400 Hz). Nevertheless, the mechanisms and degree of peripheral frequency analysis appear to be similar. Reverse correlation (revcor) studies of frequency filtering in the auditory nerve reveal two fundamental filter types in both species; one at low and one at higher frequencies. The details of the two filter functions are similar, and one can be transformed into the other by introducing a simple spectral tilt to one of the filters. This suggests that only one fundamental filter exists for each species, and that the second filter type may be derived from it through alterations in the mode of coupling between the hair cell cilia and restraint structures. In spite of this simple filtering, goldfish effectively analyze the frequency components in complex and simple sounds. In both species, primary afferents show directional preferences in 3-D space that correspond to the directionalities of hair cells. Frequency analysis and directional processing in fishes share many fundamental features with those of most other vertebrates.
Space Exploration Synthetic Aperture Radar (SESAR) (2019)

The Space Exploration Synthetic Aperture Radar is a new radar instrument development for planetary applications that will enable unprecedented surface and near-subsurface measurements of planetary bodies including the Moon, Mars, and asteroids. The radar is based on an advanced multiple-input multiple-output (MIMO) architecture that operates in the P-band (70 cm wavelength), measures full polarimetry at meter scale resolution, and achieves beam agility through programmable digital beamforming. The radar is based on a low power, lightweight, modular design approach specifically developed to meet stringent launch and operation requirements of planetary instruments. Prototype SESAR subsystems have been developed and tested, and a recent MATISSE (Maturation of Instruments for Solar System Exploration) proposal was awarded to build and test a functional radar panel.
Algorithm for determining the endpoints of isolated utterances (1974)

An important problem in speech processing is to detect the presence of speech in a background of noise. This problem is often referred to as the endpoint location problem. By accurately detecting the beginning and end of an utterance, the amount of processing of the speech data can be kept to a minimum. The algorithm proposed for locating the endpoints of an utterance is based on two measures of the signal, namely, zero crossing rate and energy. The algorithm is inherently capable of performing correctly in any reasonable acoustic environment where the signal-to-noise ratio is on the order of 30 Db or better. The algorithm has been tested over a variety of recording conditions and for a large number of speakers and has been found to perform reasonably well across all tested conditions.
MAP Kinase Activation by Receptor Tyrosine Kinases: In Control of Cell Migration (2010)

A myriad of cellular processes instigated by growth factors are mediated by cell surface-associated receptor tyrosine kinases (RTKs). Subsequent downstream activation of signaling cascades, as well as their crosstalk, endows specificity in terms of the phenotypic outcome, e.g., cellular proliferation, migration, or differentiation. Such signaling diversity is exemplified by the ability of the epidermal growth factor receptor (EGFR) to stimulate different MAPK cascades, especially the ERK1/2 cascade. It has been shown that the ability of the ERK1/2 cascade to specify cell fate, such as cell migration, is dependent on signal duration governed by feedback control. Here we focus on one experimental system, MCF10A human mammary cells, and a phenotypic outcome of cell migration. We present methods to identify key components of underlying cascades and their effects on the migratory phenotype. We focus on profiling activation of signaling modules, as well as transcriptional regulation, emphasizing the high-throughput potential of such approaches.
Dynamics of Drug Dependence (1973)

Though usually initiated through social reinforcement, self-administration of psychoactive drugs (SAPD) is soon reinforced pharmacologically through suppression (by each successive dose) of a homeostatic need generated by successive central counteradaptive changes (CCCs) that develop unconditionally in response to the initial (receptor site) actions of such drugs and their "reflex" consequences (signs of drug effects). Temporal contiguity between pharmacological reinforcement and recurring exteroceptive and interoceptive stimuli (CCs) results in increasing probability of occurrence of both CCCs and SAPD in the presence of the CSs (appetitive conditioning), even long after detoxification (DTX). To prevent relapse, both conditioned CCCs (conditioned abstinence, CA) and conditioned SAPD should be actively extinguished after DTX by elicitation of CA and programmed SAPD under conditions preventing pharmacological reinforcement. Associated psychopathologies and previous state-dependent learning may pose problems in rehabilitation.
Next generation high resolution perovskite direct conversion detector: Monte Carlo design optimisation and virtual clinical trial (2022)

We implement virtual clinical integration of next-generation perovskite detectors into common x-ray imaging devices. This was achieved by performing Monte Carlo (MC) optimisation of the design and benchmarking of low cost, high spatial resolution, direct conversion perovskite crystal x-ray flat panel imagers for a next generation of breast-, MV-, and kV-cone beam CT detectors. Semiconductor methylammonium lead bromide perovskite crystals energy deposition efficiencies calculated in TOPAS were benchmarked against four common detector materials for twelve detector crystal thicknesses between 40 to 15 mm and ten beam energies ranging from 20 keV to 6 MeV. Based on these simulations, Koning's dedicated breast CT, and Varian's Truebeam kV- and MV-cone beam CT systems were designated as suitable applications for perovskite detectors. System specific Fastcat hybrid MC cone beam CT image simulation was subsequently used to optimise the perovskite detector design and conduct virtual clinical trials. Device-specific optimal perovskite crystal thicknesses were calculated to be 0.30, 0.86, and 1.99 mm for Koning breast CT and Truebeam kV- and MV-cone beam CT systems, respectively. Replacing the current detectors on these machines with low cost perovskite crystal detectors could be advantageous as it would simultaneously yield 12.1%, 9.5% and 86.1% improvements in detective quantum efficiency as well as increases in contrast to noise ratio in brain, lung, and bone tissues.
ONCOR: design of the Dutch cardio-oncology registry (2020)

Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy-related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate.
Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives (1990)

A series of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamides was synthesized and evaluated for antiallergy activity. Several derivatives had activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity, but no derivative tested had activity at 10 mg/kg in the guinea pig anaphylaxis (GPA) assay. One analogue, N-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide , had an IC50 = 310 nM for inhibition of tritiated mepyramine binding to H1 histaminic receptors isolated from guinea pig cerebral cortex.
Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an antiperspirant (1976)

Out of 14 patients with axillary dermatitis due to an antiperspirant, and with positive patch test reactions to the product, the sensitizer could be demonstrated in 12. Of these, 11 were positive to propantheline bromide, 3 to trichlorocarbanilide and one to propylene glycol. The antiperspirant contains 90% propylene glycol, which is an irritant under occlusion. When applied in the axillae, where occlusive conditions usually prevail, an irritant effect of propylene glycol may have promoted sensitization to the ingredients of the antiperspirant.
Simple gelation procedure for liquid scintillation counting (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple gelation procedure for liquid scintillation countingJames N. Bollinger, William A. Mallow, James W. Register, and Donald Edgar. JohnsonCite this: Anal. Chem. 1967, 39, 12, 1508–1509Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/ac60256a015https://doi.org/10.1021/ac60256a015research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the minimum distance of turbo codes (2003)

A permutor (interleaver) design method is presented to show the existence of turbo codes with minimum distance growing logarithmically with the permutor length. It is demonstrated, that the method can also be useful for the construction of turbo codes with practical block lengths.
Synthesis and Characterization of Isotopically Enriched Pyrimidine Deoxynucleoside Oxidation Damage Products (1998)

Oxidative damage to DNA is an established source of genomic instability. In this paper, we describe the synthesis and characterization of several pyrimidine deoxynucleoside oxidation damage products, enriched with stable isotopes. These products include the 2'-deoxynucleoside derivatives of 5-(hydroxymethyl)uracil, 5-formyluracil, 5-hydroxyuracil, 5-(hydroxymethyl)cytosine, 5-formylcytosine, and 5-hydroxycytosine. The common precursor is 2'-deoxy-2"-deutero[1,3-15N]uridine. Additional stable isotopes are added during functional group conversions. Characterization of these derivatives includes mass spectrometry and 1H and 15N NMR spectroscopy. Proton and nitrogen NMR studies reported here allow an examination of the influence of the modification on sugar conformation and tautomeric equilibrium, properties likely to be important in understanding the biological consequences of these DNA damage products.
4D Electronic Systems: Transformable, Freestanding 3D Mesostructures Based on Transient Materials and Mechanical Interlocking (Adv. Funct. Mater. 40/2019) (2019)

In article number 1903181, Yihui Zhang, John A. Rogers, and co-workers propose integrating transient materials into 3D structures, which serves as the basis for an attractive route to 4D, or transformable 3D architectures and functional electronic devices. Such devices could create opportunities for unusual applications for 3D assembly techniques, such as medical devices, microbotics, and flexible electronics.
Solution-state conformations of natural products from chiroptical spectroscopy: the case of isocorilagin (2016)

Isocorilagin, the α-anomer of the ellagitannin corilagin, has been frequently reported in the literature as a constituent of various plant species. Its identification is based mainly on the smaller value for the coupling constant of its anomeric proton when compared to that of corilagin. A careful investigation of the corilagin structure in both methanol and DMSO solutions using NMR, electronic and vibrational CD, and DFT and MD calculations confirmed that isocorilagin is the result of a solvent-induced conformational transition of corilagin, rather than its diastereoisomer. Corilagin changes from B1,4 and (o)S5 conformations of the β-glucose core in DMSO-d6 to an inverted (1)C4 conformation in methanol-d4, which accounts for NMR observables attributed to the alleged α-anomer. This misassignment reinforces the risks of relying upon a single technique for structural elucidation and stereochemical analysis of complex natural products, especially those containing saccharide moieties.
Software-type Wave-Particle Interaction Analyzer (SWPIA) by RPWI for JUICE: Science objectives and implementation (2016)

We present science objectives of the Software–type Wave–Particle Interaction Analyzer (S–WPIA), which will be realized as a software function of the LowFrequency receiver (LF) running on the DPU of RPWI (Radio and Plasma Waves Investigation) for the ESA JUICE mission. S–WPIA conducts onboard computations of physical quantities indicating the energy exchange between plasma waves and energetic ions. Onboard inter–instruments communications are necessary to realize S–WPIA, which will be implemented by eﬀorts of RPWI, PEP (Particle Environment Package) and J–MAG (JUICE Magnetometer). By providing the direct evidence of ion energization processes by plasma waves around Jovian satellites, S–WPIA increases the scientiﬁc output of JUICE while keeping its impact on the telemetry data size to a minimum: S–WPIA outputs 0.2 kB at the smallest from 440 kB waveform and particle raw data.\n
Under pressure (1974)

The once 'dangerous and expensive hobby' of high pressure spectroscopy can now be fairly described as 'a moderately priced, academically and economically rewarding' scientific technique. These aspects, of safety and expense, were two of the major topics discussed at the Spectroscopy Group's one day meeting on 26 September.
Unifying tool, data and process flow management (1992)

Typically, modern design management is achieved through either a data management system or a flow sequence controller. Each is highly productive in specific parts of a design process, but becomes cumbersome in others. A design management approach which is generally applicable throughout the development of a product is presented. It offers flow control and automation to manage readily definable processes, while also being able to ensure data consistency where the task sequence is determined on-the-fly and a process flow cannot be predefined. The capability is part of the Texas Instruments Flagship Design System and is implemented using Falcon Framework technology. >
Heavy Metal Sorption on Clay Minerals Affected by the Siderophore Desferrioxamine B (2000)

Siderophores are released by microorganisms to ensure their iron nutrition through the dissolution of iron(III) oxides. These compounds can also chelate divalent heavy metal ions and may therefore affect heavy metal sorption and mobility in soils. Using model systems, we studied the influence of the hydroxamate siderophore desferrioxamine B (DFOB) on the adsorption of Cu, Zn, and Cd on Na-montmorillonite and kaolinite. In the absence of heavy metals, DFOB was adsorbed onto montmorillonite much stronger than onto kaolinite. In montmorillonite suspensions, heavy metal sorption was enhanced by DFOB due to electrostatic interactions. Only at high pH values, a mobilizing effect of DFOB was observed for Zn and Cd. In kaolinite suspensions, DFOB drastically diminished heavy metal sorption. Surface complexation modeling revealed that the different effects of DFOB on the metal sorption by kaolinite and montmorillonite can be explained by the large difference in their permanent negative surface charge responsible for the attraction of the positively charged metal DFOB complexes. The effect of DFOB on the adsorption of heavy metal ions on montmorillonite and kaolinite decreased in the sequence Cu > Zn > Cd in accordance with complex stability constants.
Wireless LAN performance under varied stress conditions in vehicular traffic scenarios (2003)

Mobile ad-hoc networking with wireless LAN infrastructure can be employed to build inter-vehicle communication based applications. The associated high velocities and hostile driving environments pose a challenge to the performance of a wireless LAN. This paper assesses the performance of a wireless local area network in different vehicular traffic and mobility scenarios. The network throughput and the quality of the wireless communication channel, measured on IEEE 802.11b compliant equipment, are observed to degrade with increasingly stressful communication scenarios. The test scenarios are varied by conducting the experiments under different vehicular mobility, peer-distance and driving environment conditions. We present results that can facilitate development of efficient applications for inter-vehicular communication. We also suggest optimization measures through aggression control via variations in packet size.