gebhart/patrepeval huggingface dataset:
Research on architecture and query performance based on distributed graph database Neo4j (2013)

Neo4j database based on graph model is different from other database on implementation. Firstly, this paper explores the architecture of the system and its internal mechanism. Secondly, Neo4j offers three ways to query, and evaluate its query performance from several dimensions: data size, query complexity, query number, etc. The results show that there are obvious difference in performance under different scenarios. This paper analyzes the experimental results and selection suggestions of query ways are recommended later. It provides a reference of query performance optimization for specific business applications.
Characterization of the Oxygen Tolerance of a Hydrogenase Linked to a Carbon Monoxide Oxidation Pathway in Rubrivivax gelatinosus (2002)

A hydrogenase linked to the carbon monoxide oxidation pathway in Rubrivivax gelatinosus displays tolerance to O2. When either whole-cell or membrane-free partially purified hydrogenase was stirred in full air (21% O2, 79% N2), its H2 evolution activity exhibited a half-life of 20 or 6 h, respectively, as determined by an anaerobic assay using reduced methyl viologen. When the partially purified hydrogenase was stirred in an atmosphere containing either 3.3 or 13% O2 for 15 min and evaluated by a hydrogen-deuterium (H-D) exchange assay, nearly 80 or 60% of its isotopic exchange rate was retained, respectively. When this enzyme suspension was subsequently returned to an anaerobic atmosphere, more than 90% of the H-D exchange activity was recovered, reflecting the reversibility of this hydrogenase toward O2 inactivation. Like most hydrogenases, the CO-linked hydrogenase was extremely sensitive to CO, with 50% inhibition occurring at 3.9 microM dissolved CO. Hydrogen production from the CO-linked hydrogenase was detected when ferredoxins of a prokaryotic source were the immediate electron mediator, provided they were photoreduced by spinach thylakoid membranes containing active water-splitting activity. Based on its appreciable tolerance to O2, potential applications of this hydrogenase are discussed.
The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner (2009)

The cytoplasmic deacetylase HDAC6 is an important regulator of cellular pathways that include response to stress, protein folding, microtubule stability, and cell migration, thus representing an attractive target for cancer chemotherapy. However, little is known about its upstream regulation. Our previous work has implicated HDAC6 as a new protein target for the farnesyltransferase inhibitors (FTIs), although HDAC6 lacks a farnesylation motif. Here we show that the protein farnesyltransferase (FTase) and HDAC6 are present in a protein complex together with microtubules in vivo and in vitro. FTase binds microtubules directly via its alpha subunit, and this association requires the C terminus of tubulin. Treatment with an FTI removed FTase, but not HDAC6, from the protein complex, suggesting that the active form of FTase is bound to microtubules. Importantly, the removal of FTase from microtubules abrogated HDAC6 activity, as did a stable knockdown of the alpha subunit of FTase (FTalphaKD). Interestingly, the FTalphaKD cells showed increased sensitivity to the antiproliferative effects of Taxol and the FTI lonafarnib when used either as single agents or in combination as compared with parental cells. Altogether, these data suggest that FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity and that FTase expression could help stratify cancer patients that would most benefit from this treatment.
Porous Si/Fe2O3 Dual Network Anode for Lithium–Ion Battery Application (2020)

Benefiting from ultra-high theoretical capacity, silicon (Si) is popular for use in energy storage fields as a Li-ion battery anode material because of its high-performance. However, a serious volume variation happens towards Si anodes in the lithiation/delithiation process, triggering the pulverization of Si and a fast decay in its capacity, which greatly limits its commercial application. In our study, a porous Si/Fe<sub>2</sub>O<sub>3</sub> dual network anode was fabricated using the melt-spinning, ball-milling and dealloying method. The anode material shows good electrochemical performance, delivering a reversible capacity of 697.2 mAh g<sup>-1</sup> at 200 mA g<sup>-1</sup> after 100 cycles. The high Li storage property is ascribed to the rich mesoporous distribution of the dual network structure, which may adapt the volume variation of the material during the lithiation/delithiation process, shorten the Li-ion diffusion distance and improve the electron transport speed. This study offers a new idea for developing natural ferrosilicon ores into the porous Si-based materials and may prompt the development of natural ores in energy storage fields.
Are Softγ-Ray Repeaters Strange Stars? (1998)

The soft $\ensuremath{\gamma}$-ray repeaters (SGRs) are proposed to result from young, magnetized strange stars with superconducting cores. As such a strange star spins down, the quantized vortex lines move outward and drag the magnetic flux tubes because of the strong coupling between them. Since the terminations of the tubes interact with the stellar crust, the dragged tubes can produce sufficient tension to crack the crust and pull parts of the broken platelet into the quark core. The deconfinement of crustal matter into strange quark matter will release energy. The model burst energy, duration, time interval, spectrum, and the persistent x-ray emission from SGRs are shown to be in agreement with observed results.
Elemental iron: reduction of pertechnetate in the presence of silica and periodicity of precipitated nano-structures (2020)

Enhanced TcO<sub>4</sub><sup>−</sup> reduction by metallic Fe<sup>0</sup> in the presence of particulate and structural Si. Rhythmical precipitation of dissolved iron leads to formation of layered structures related to geological phenomena such as orbicular rocks and Liesegang rings.
Total synthesis of (±)-furoscrobiculin B (1997)

Total synthesis of (±)-furoscrobiculin B, a lactarane sesquiterpene isolated from basidiomycetes of mushrooms, has been achieved via an improved synthetic route of our previous work based on a Furan Ring Transfer (FRT) reaction and base-catalysed pinacol-type rearrangement.
Production of iminodiacetic acid by electrodeionization with bipolar membrane (2011)

In view of some inherent disadvantage of traditional technique, a special electrodeionization(BMEDI) process coupled with bipolar membrane was developed to produce iminodiacetic acid (IDA) from iminodiacetic acid disodium salt (IDANa <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). The BMEDI stack comprises three compartments which are separated with two bipolar membranes, one cation exchange membrane and one anion exchange membrane. The influences of operation time, current density and IDANa <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> concentration on the operating performances were investigated. The results show that with current density of 10 mA·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−2</sup> and IDANa <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> concentration of 0.1 mol·L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> , the recovery rate of IDA could reach 86.7%. It was indicated that the recovery rate of IDA and energy consumption increased as current density increased, and current efficiency increased as IDANa <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> concentration increased.
Dosing‐Time–Dependent Differences in Lipopolysaccharide‐Induced Liver Injury in Rats (2005)

Dosing-time-dependent differences in lipopolysaccharide (LPS)-induced liver injury were examined in rats housed under a 12 h light : dark (LD) cycle. LPS (5 mg/kg) was intravenously injected into different groups of rats at 2, 14, or 20 h after light on (HALO). Elevations in serum liver enzymes after 14 HALO were significantly greater than those after 2 HALO. These parameters were lower in rats given LPS at 20 HALO, compared to 14 HALO. The number of polymorphonuclear cells (PMN) in the liver and the amount of hepatic myeloperoxidase activity, which reflects the number of PMN in liver tissues, was significantly greater in the 14 than in the 2 HALO group. In addition, hepatic interleukin-6 (IL-6) production in the 14 HALO group was enhanced compared to that in the 2 HALO trial. These results suggest that LPS-induced liver injury is greater during the early active than during the early resting period. Dosing-time-dependent variation in the accumulation of PMN in the liver and, potentially, subsequent IL-6 production in liver tissues might be involved in this phenomenon.
Geometry and electronic structure of bis-(glycinato)-CuII·2H2O complexes as studied by density functional B3LYP computations (1999)

Geometry optimizations using the density functional method B3LYP with a variety of basis sets were performed on bis-(glycinato)-CuII·2H2O complexes. The geometry and electronic structure were probed with various basis sets and natural population analysis. Geometry optimizations should at least be performed with the all-electron basis set 6-311+G(d,p) or with C, H, N, O=6-311+G(d,p) and an effective core potential for Cu; spurious minima were found with smaller basis sets. Two real minima were found on these potential energy surfaces: a trans configurated complex of Ci symmetry, and a cis configurated complex with C1 symmetry. Invacuo the trans structure is more stable by 18 kcal mol-1, which reduces to 10 kcal mol-1 in a dielectric medium representing water. The final geometries strongly depend on the number of hydrogen bonds formed between the coordinating water molecules and the amino and carboxylate functionalities, as formation of such hydrogen bonds competes with axial CuII···OH2 interactions.
Hereditary xanthinuria in a goat (2019)

A 2-year-old mixed breed goat was presented for a 1-day history of anorexia and 1 week of weight loss. Serum biochemistry disclosed severe azotemia. Abdominal ultrasound examination showed decreased renal corticomedullary distinction, poor visualization of the renal pelves, and dilated ureters. On necropsy, the kidneys were small, the pelves were dilated, and the medulla was partially effaced by variably sized yellow nephroliths. Histologically, cortical and medullary tubules were distended by yellow-brown, multilayered crystals. Stone composition was 100% xanthine. Exonic sequencing of xanthine dehydrogenase (XDH) and molybdenum cofactor sulfurase (MOCOS) identified 2 putative pathogenic variants: a heterozygous XDH p.Leu128Pro variant and a homozygous MOCOS p.Asp303Gly variant. Variant frequencies were determined in 7 herd mates, 12 goats undergoing necropsy, and 443 goats from genome databases. The XDH variant was not present in any of these 462 goats. The MOCOS variant allele frequency was 0.03 overall, with 3 homozygotes detected. Hereditary xanthinuria is a recessive disorder in other species, but the XDH variant could be causal if the case goat is a compound heterozygote harboring a second variant in a regulatory region not analyzed or if the combination of the XDH and MOCOS variants together abolish XDH activity. Alternatively, the MOCOS variant alone could be causal despite the presence of other homozygotes, because hereditary xanthinuria in humans often is asymptomatic. Ours is the first report describing the clinical presentation and pathology associated with xanthine urolithiasis in a goat. The data support hereditary xanthinuria, but functional studies are needed to conclusively determine the causal variant(s).
Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, But Not IL-10 (2000)

Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent induction of immunomodulatory genes leading to the production of pro-inflammatory cytokines. In this paper, we compared the expression and response of TLRs on monocytes and dendritic cells (DC). TLR2, but not TLR4, was detected on peripheral blood monocytes and DC, in lymphoid tissue CD1alpha+ DC as well as on in vitro monocyte-derived DC. Upon stimulation with bLP or LPS, monocytes produced IL-12 and IL-10 at similar levels, whereas monocyte-derived DC produced comparable levels of IL-12, but little IL-10. Greater than 90% of the bLP-induced production of IL-12 was blocked by anti-TLR2 mAb. Thus, DC express TLR2 and activation of this receptor by bLP provides an innate mechanism by which microbial pathogens preferentially activate cell-mediated immunity.
Antiphase boundaries and rotation domains in In2O3(001) films grown on yttria-stabilized zirconia (001) (2014)

In 2 O 3 is important because it has been widely used as a transparent contact material and an active gas sensor material. To understand and utilize its intrinsic physics as a semiconductor, it is necessary to have In 2 O 3 with a high material quality. In this article, single-crystalline (001)-oriented In 2 O 3 thin films were grown on yttria-stabilized zirconia (001) substrate, and a group theory analysis and transmission electron microscopy (TEM) experiments were conducted to investigate the defects within the In 2 O 3 film. Owing to the reduced symmetry of the bixbyite structure (space group Ia{\overline 3}) in comparison with the fluorite template (space group Fm {\overline 3}m), the formation of antiphase domains and 90° rotation domains in the In 2 O 3 thin films is anticipated. This prediction is confirmed experimentally by TEM and high-angle annular dark-field scanning transmission electron microscopy images. The size of the enclosed domains ranges from 50 to 300 nm, and the major domain boundaries are along the (110), (1{\overline 1}0), (010) and (100) planes. The rotation domains are related by a fourfold rotation operation along the 〈001〉 directions, which will cause the permutation of the axes of the bixbyite structure.
AMPA Receptor Antagonists as Potential Anticonvulsant Drugs (2005)

Over the last years alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.
The tensile properties of electrospun nylon 6 single nanofibers (2010)

Abstract In this article, we have aimed to mechanically characterize the nylon 6 single nanofiber and nanofiber mats. We have started by providing a critical review of the developed mechanical characterization testing methods of single nanofiber. It has been found that the tensile test method provides information about the mechanical properties of the nanofiber such as tensile strength, elastic modulus and strain at break. We have carried out a tensile test for nanofiber/composite MWCNTs nanofiber mats to further characterize the effect of the MWCNTs filling fiber architecture. In addition, we have designed and implemented a novel simple laboratory set‐up for performing tensile test of single nanofibers. As a result, we have established the stress–strain curve for single nylon 6 nanofibers allowing us to define the tensile strength, axial tensile modulus and ultimate strain of this nanofiber. The compared values of the tensile strength, axial modulus and ultimate strain for nylon 6 nanofiber with those of conventional nylon 6 microfiber have indicated that some of the nylon 6 nanofiber molecule chains have not been oriented well along the nanofiber axis during electrospinning and through the alignment mechanism. Finally, we have explained how we can improve the mechanical properties of nylon 6 nanofibers and discussed how to overcome the tensile testing challenges of single nanofibers. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1719–1731, 2010
Entanglement in the steady state of a collective-angular-momentum (Dicke) model (2002)

We model the behavior of an ion trap with all ions driven simultaneously and coupled collectively to a heat bath. The equations for this system are similar to the irreversible dynamics of a collective angular momentum system known as the Dicke model. We show how the steady state of the ion trap as a dissipative many-body system driven far from equilibrium can exhibit quantum entanglement. We calculate the entanglement of this steady state for two ions in the trap and in the case of more than two ions we calculate the entanglement between two ions by tracing over all the other ions. The entanglement in the steady state is a maximum for the parameter values corresponding roughly to a bifurcation of a fixed point in the corresponding semiclassical dynamics. We conjecture that this is a general mechanism for entanglement creation in driven dissipative quantum systems.
Fluctuations of systems in finite heat reservoirs with applications to phase transitions in lipid membranes (2013)

In an adiabatically shielded system, the total enthalpy is conserved. Enthalpy fluctuations of an arbitrarily chosen subsystem must be buffered by the remainder of the total system which serves as a heat reservoir. The magnitude of these fluctuations depends on the size of the reservoir. This leads to various interesting consequences for the physical behavior of the subsystem. As an example, we treat a lipid membrane with a phase transition that is embedded in an aqueous reservoir. We find that large fluctuations are attenuated when the reservoir has finite size. This has consequences for the compressibility of the membrane since volume and area fluctuations are also attenuated. We compare the equilibrium fluctuations of subsystems in finite reservoirs with those in periodically driven systems. In such systems, the subsystem has only finite time available to exchange heat with the surrounding medium. A larger frequency therefore reduces the volume of the accessible heat reservoir. Consequently, the fluctuations of the subsystem display a frequency dependence. While this work is of particular interest for a subsystem displaying a transition such as a lipid membrane, some of the results are of a generic nature and may contribute to a better understanding of relaxation processes in general.
Research Guides: Chem216 Synthesis and Characterization of Organic Compounds: Home (2010)

Help you get started with obtaining physical properties and spectroscopic data of substances as well as organic reactions information from Reaxys and other resources.
Safe Startup Method for Zero-Voltage-Switching MOSFET Grid Inverter (2018)

Zero-voltage-switching (ZVS) <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mosfet</small> grid inverter has distinct advantages such as higher efficiency and higher power density. However, the ZVS inverter may lose ZVS condition during startup stage if it does not start properly. It may increase the voltage stress on <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mosfet</small> s and even destroy the power semiconductor device. In order to achieve the ZVS condition for ZVS inverter during the startup stage, this paper proposes a safe startup method with an auxiliary clamping capacitor pre-charging circuit and designed ZVS pre-charging pulse sequence. The pre-charging circuit is enabled only at the startup stage. Theoretical analysis shows that the proposed method is capable of reducing the voltage stress during the startup stage for the ZVS inverter. Finally, the proposed safe startup method is verified on a 3 kW grid inverter.
Waldenstrom's macroglobulinemia and peripheral neuropathy: a clinical and immunologic study of 25 patients (1983)

We investigated, by indirect immunofluorescence, the binding of monoclonal IgM to human peripheral nerve in 25 patients with Waldenström's macroglobulinemia and peripheral neuropathy. In 10 cases (40%), an antibody activity against the myelin sheaths was demonstrated. The reactivity was mediated by the F(ab')2 fragments of the IgM. Prior delipidation of nervous tissue was needed to allow full expression of the target antigen(s). In nine cases, the IgM reacted with both peripheral and central myelin of primates, but not mouse or rabbit nervous tissue. In one case, the IgM reacted only with human peripheral nerve. The patients, whose IgM had an antibody activity to myelin antigen(s), had some distinct hematologic and neurologic features. The peripheral neuropathy always antedated the hematologic symptoms by several years. The serum level of the monoclonal IgM was low in all cases, and overt lymphoid malignancy was frequently absent. In other patients with neuropathy, the monoclonal IgM, which lacked antimyelin antibody activity, displayed either cross-idiotypic antigenic determinants or anti-intermediate filament antibody activity. These results taken together emphasize the heterogeneity of antibody activity of the monoclonal IgM from patients with Waldenström's macroglobulinemia and peripheral neuropathy.
On the Combination Coefficient of Positive Ions with Ultrafine Neutral Particles in the Transition and Free-Molecule Regimes (1992)

The charged fraction of ultrafine silver particles (5–50 nm) suspended in high-purity helium (99.998% grade) was measured as a function of particle size under different charging conditions (i.e., ion concentration and charging time). The charger used is a modified version of the one described in a previous study (Romay et al., 1991). Two radioactive sources of 250 μCi Po-210 are located in a cavity at the charger inlet. The cavity configuration is designed to control the range of the α rays. The modified charger provides a uniform electric field in the axial direction to separate the positive ions from the negative ions and electrons produced by the ionizing radiation. Thus, the aerosol particles are first exposed to a small region of electrons and positive ions, and are subsequently charged by positive ions in a much longer section of the charger. The ion concentration is estimated from the ion current collected in the exit electrode and measured with a picoammeter. The charging time is estimated from the length of the unipolar section of the charger and from the flow velocity profile in the charger. Experiments were performed to measure the fraction of uncharged particles by using a condensation particle counter equipped with a multichannel analyzer. From the measured uncharged fraction, ion concentration and charging time, the combination coefficient between positive ions and neutral particles was determined. The Knudsen number of the experimental data ranged from 2.4 to 24. The results were compared with the combination coefficient calculated using several available theories. It is concluded that Fuchs' limiting-sphere theory (1963), using ion properties of He2 +, gives the best agreement with the experimental results.
High order mode (HOM) dispersion compensating fibers for true time delay applications (2003)

We demonstrate for the first time the use of highly dispersive, high-order-mode (HOM) dispersion compensating modules for True Time Delay applications. Very low phase ripple is obtained (