gebhart/patrepeval huggingface dataset:
Foreword (2017)

On behalf of the Program, Organizing, and Steering Committees, we would like to extend a warm welcome to everyone attending the European Test Symposium 2017 (ETS'17). ETS has been established as one of the main international forums and the larger forum in Europe that brings together the test community to discuss emerging ideas, views, and trends in the area of electronic-based circuits and system testing. Topics of interest include, but are not limited to, design-for-test, dependability, security, failure analysis and diagnosis, on-line test, automated test hardware, validation and verification, fault simulation, fault tolerance, automatic test generation, etc.
Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: Evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts (1999)

Previous studies suggest that the relationship between genes and nonsyndromic cleft lip +/- cleft palate (CLP) or cleft palate only (CP) may be modified by the environment. Using data from a population-based case-control study, we examined allelic variants for three genes, i.e., transforming growth factor alpha (TGFA), transforming growth factor beta 3 (TGFB3), and Msh (Drosophila) homeobox homolog 1 (MSX1), and their interactions with two exposures during pregnancy (maternal cigarette smoking and alcohol consumption) as risk factors for CLP and CP. For each cleft phenotype, risk estimates associated with most allelic variants tended to be near unity. Risk estimates for maternal smoking (> or = 10 cigarettes/day) were significantly elevated for CP and were most elevated among infants with allelic variants at the TGFB3 or MSX1 sites. By comparison, risk estimates for maternal alcohol consumption (> or = 4 drinks/month) were significantly elevated for CLP and were most elevated among infants with allelic variants at the MSX1 site. Our results suggest that development of CLP and CP may be influenced independently by maternal exposures but more significantly by interaction of such exposures and specific allelic variants.
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure (2008)

In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known. We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and mir-125 miRNAs. Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene.
Poster Abstract: An Efficient Authentication Model in Smart Grid Networks (2016)

A smart grid is envisioned as a promising platform for the next-generation power supply network, where the electricity is generated based on the demand from the consumers energy-use information. However, the security and privacy issues over insecure wireless communications are still big obstacles in the success of smart grid networks. In this paper, we present an efficient authentication model in smart grid networks. The proposed model justifies its feasibility with an early test-bed using off-the-shelf 802.15.4 low- cost sensors. Moreover, this poster reports preliminary performance evaluation results, and shows that the proposed scheme is effective and efficient than the prior works.
ABOUT THE RELATIONSHIP BETWEEN PSICOTHERAPISTS IN SUPERVISION (2020)

psicoterapeuta.O processo que mais importância adquire é a relação.
KinLinks: Software Toolkit for kinship analysis and pedigree generation from HTS datasets (2016)

The ability to predict familial relationships from source DNA in multiple samples has a number of forensic and medical applications. Kinship testing of suspect DNA profiles against relatives in a law enforcement database can provide valuable investigative leads, determination of familial relationships can inform immigration decisions, and remains identification can provide closure to families of missing individuals. The proliferation of High-Throughput Sequencing technologies allows for enhanced capabilities to accurately predict familial relationships to the third degree and beyond. KinLinks, developed by MIT Lincoln Laboratory, is a software tool that predicts pairwise relationships and reconstructs kinship pedigrees for multiple input samples using single-nucleotide polymorphism (SNP) profiles. The software has been trained and evaluated on a set of 175 subjects (30,450 pairwise relationships), consisting of three multi-generational families and 52 geographically diverse subjects. Though a panel of 5396 SNPs was selected for kinship prediction, KinLinks is highly modular, allowing for the substitution of expanded SNP panels and additional training models as sequencing capabilities continue to progress. KinLinks builds on the SNP-calling capabilities of Sherlocks Toolkit, and is fully integrated with the Sherlocks Toolkit pipeline.
“The Graves of the Gallant Highlanders”: <em>Memory, Interpretation and Narratives of Culloden</em> (2007)

The battlefield at Culloden (Scotland), which witnessed the defeat in April 1746 of the forces of Prince Charles Edward Stuart in a battle against forces loyal to the Hanoverian King George II, remains a site charged with powerful associations. Largely forgotten for a century, the memories of the battle were steadily revived and recast under the influence of romantic Jacobitism, eventually turning the battlefield from undifferentiated moorland into sacred space. This article traces this process and reflects on its lasting implications. After surveying the nature of Jacobitism, especially its transformation from a political to a predominantly romantic movement, it considers film representations of Culloden as a way of unpacking the myths of romantic Jacobitism. The type of reinterpretations found in film, however, have only slowly permeated the narratives presented at the site itself. The conclusion discusses issues arising from the experience of Culloden, making particular reference to the recently announced Memorial Project.
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology (2020)

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to a substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains an urgent need to find other therapeutic approaches to either target SARS-CoV-2 or the complications arising from viral infection, particularly the dysregulated immune response and systemic complications which have been associated with progression to severe COVID-19. At the time of writing, in vivo studies of SARS-CoV-2 infection have been described using macaques, cats, ferrets, hamsters, and transgenic mice expressing human angiotensin I converting enzyme 2 (ACE2). These infection models have already been useful for studies of transmission and immunity, but to date only partly model the mechanisms involved in human severe COVID-19. There is therefore an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID-19. These models need to reproduce the key mechanisms of COVID-19 severe acute respiratory distress syndrome and the immunopathology and systemic sequelae associated with this disease. Here, we review the current models of SARS-CoV-2 infection and COVID-19-related disease mechanisms and suggest ways in which animal models can be adapted to increase their usefulness in research into COVID-19 pathogenesis and for assessing potential treatments. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.
Intimacy, Gender and Self Psychology: Considerations for Relationship Counselling (2001)

This paper reviews major conceptualisations of intimacy and the blocks, frequently attributed to gender, which are thought to contribute to problems in couple relationships. The paper concludes that gender is often not the limiting factor that inhibits intimacy in heterosexual couples. It may be more productive to consider individual rather than couple therapy to deal with impasses that appear to be associated with gender. Ideas from self psychology provide insights into how some requests for intimacy may be related to immature self‐object needs, which may better be handled through individual rather than couple therapy. A range of therapeutic goals and strategies that focus directly on intimacy are then outlined.
ChemInform Abstract: Synthesis of Hydroxymethyl‐Functionalized Diazacrowns and Cryptands. (1986)

Abstract Aus dem Diol (Ia) werden das Säurechlorid (Ic) sowie das Bis‐mesylat (Ie) in üblicher Weise hergestellt.
Stability parameter identification for a centrifugal compression system (2004)

This paper presents the application of a lumped parameter model to describe the dynamic behavior of a centrifugal compression system including surge. The response of the model is compared with experimental surge measurements from an industrial single stage compressor test rig. A parametric analysis of the model reveals the large influence of the stability parameter on the transient response. However, a good value for this parameter is not easily obtained from surge data. Therefore, an identification method is proposed to uniquely determine the stability parameter that is based on an approximate realization algorithm, making use of the fact that the step response of the system has the characteristics of a first order system. Simulation results show that this method can provide an estimate for the stability parameter of a centrifugal compression system.
Fluid-Screen as a Real Time Dielectrophoretic Method for Universal Microbial Capture (2021)

Abstract Dielectrophoresis (DEP) has shown great promise for particle separation for decades; however, it has not yet been widely applied in routine laboratory setting. This paper provides an overview of a new DEP microbial capture and separation method called Fluid-Screen (FS), that achieves an efficient, reliable and repeatable capture and separation of microbial cells. Method verification experiments demonstrated that the FS system captured 100% of bacteria in test samples, a capture efficiency much higher than previously reported for similar technology. Data generated supports the superiority of the FS method as compared to the established Plate Counting Method (PCM), that is routinely used to detect bacterial contamination in healthcare, pharmacological and food industries. We have established that the FS method is universal and can capture and separate different species of bacteria and fungi to viruses, from various sample matrices (i.e. human red blood cells, mammalian cells).
Optical phase space distributions for low coherence light in turbid media (2003)

Summary form only given. Optical phase space distributions are joint position and momentum distributions of light fields. They are related to the Wigner distributions for the optical field, which allows them to be placed on a firm theoretical footing. Since Wigner distributions are Fourier transforms of the mutual coherence function, optical phase space measurements are sensitive to the coherence properties of the light field. It has been suggested that coherence tomography based on measurement of the Wigner distributions may yield new avenues for medical imaging. The authors have demonstrated that smoothed Wigner phase space distributions of light fields can be measured directly as optical phase space contours using a simple heterodyne scheme.
Rhodium(II)-carbenoid C–H insertion reactions in the synthesis of β-oxospirane systems (2000)

A simple one-pot procedure is described for the preparation of spiro[4.4]nonane-2,7-dione derivatives from open chain bis(α-diazoketones) by two consecutive intramolecular Rh(II)-catalyzed carbenoid insertion reactions. With 1-diazo-4-(3-oxocycloalkyl)butan-2-ones as substrates, the methodology provides 2,7-dioxospiranes with a cyclopentane ring spiroannulated onto a five-, six- or seven-membered cycloalkane.
TFT-LCD uneven brightness correction and recognition of MURA area based on EMD method (2016)

In automatic visual inspection of TFT-LCD, MURA defect is difficult to recognize due to uneven brightness of the panel. This paper proposed a preprocessing method to eliminate such unevenness using Empirical Mode Decomposition (EMD). Comparing to existing algorithms, such as the Principal Components Analysis (PCA), this method provided a more integral distribution of the unevenness. Then a grey level nonlinear transformation was proposed to eliminate the unevenness of the original image. Besides eliminating the unevenness, results indicated that the EMD method can further give the upheaval features, as white points and texture features, and graded features, as MURA defect, which suggested that it may be possible to extract the MURA defect in an uneven illumination image by the proposed method.
Quantification of serum and cerebrospinal fluid gelsolin in familial amyloidosis, Finnish type (AGel) (1994)

Familial amyloidosis, Finnish type (FAF) or AGel is an autosomal dominant systemic amyloidosis, characteristic symptoms of which are progressive polyneuropathy and corneal lattice dystrophy. The amyloid in FAF patients consists of peptides of an actin modulating protein, gelsolin, with the substitution ofAsn or of Tyr for Asp187. We developed a novel competitive radioimmunoassay for gelsolin quantification in serum and CSF The serum gelsolin concentration in our patient material was significantly higher (248 μg/ml) than in the controls (179 μg/ ml) (P=0.0012). The serum gelsolin levels inpatients correlated with age (P=0.0001), whereas no age-dependency was observed in the control group. The mean CSF gelsolin concentration in patients below the age of 50 was lower (7.1 μg/ml) than in controls (10.8 μg/ml), but increased with age in the patient group (P=0.014), as did the total CSF protein (P=0.015). Immunoblotting with antibodies to gelsolin revealed one extra fragment of 60 IcDA in the serum and two extra fragments of 60–85 kDa in the CSF of the patients. These findings suggest that the metabolism of gelsolin is altered in FAF The novel RIA method presented here can serve as a valuable tool in future analyses aimed at monitoring the gelsolin level in vitro or in vivo.
Plasmonic and High Index Nanostructures for Efficient Solar Energy Conversion (2011)

Nanometallic (i.e. plasmonic) and high index dielectric nanostructures have gained significant interest for their ability to boost the energy conversion efficiency of photovoltaic and photo-electrochemical cells. Such structures can help direct the flow of light into those regions of the cell where photo-generated carriers are most effectively used. In doing so, we can address one of the main limitations of current solar cell designs: the large mismatch between the relevant electronic length-scale (minority carrier or exciton diffusion length) and photonic length-scale (absorption depth of light). I will discuss recent progress in the development of periodic/aperiodic plasmonic and high index structures to boost performance of energy conversion devices.
Applicability of an Online Decision-Support Tool (WEPPcloud) to Watershed-Scale Forest Management in the Western US (2023)

<b>Abstract.</b> The Water Erosion Prediction Project (WEPP) model is a process-based computer simulation model that has been widely used in research and by land managers to predict runoff and soil erosion from both agricultural and forested areas. While the model can produce accurate predictions with proper input data and minimal calibration, its usability has been limited by data accessibility and processing, and model setup. WEPPcloud is a free online interface developed mainly for forest applications that allows users to run WEPP without explicit knowledge of GIS and computer programming or even the area being modeled. All input files for the WEPP model are either automatically created from freely available databases or are used directly from an extensive WEPP database stored locally on the server. WEPPcloud also includes algorithms to simulate phosphorus yield based on simple static phosphorus concentrations in surface runoff, subsurface lateral flow, baseflow, and particulate phosphorus concentration attached to sediment. <fig><graphic xlink:href=23038_files/23038-00.jpg id=ID_113625db-ecb6-4473-948c-b39d879bb1e9></graphic></fig> Recently, the WEPPcloud capabilities have been used in various applications to aid land managers with making decisions about pre- and post-fire fuel management and soil erosion. We will specifically present results from a basin-wide modeling effort in the Lake Tahoe Basin (Figure 1) where we compared several management scenarios (uniform high, moderate, and low severity, uniform thinning, simulated wildfire under current climate and future climate conditions) to current management conditions based on historic weather data. Similarly, we will demonstrate the applicability of the WEPPcloud interface to two municipal watersheds in Portland and Seattle, respectively. All hydrologic simulations were conducted online with the WEPPcloud interface. Minimum calibration was performed on watersheds using data from a USGS gauging station and calibrated parameters were applied uniformly to all modeled watersheds. All results are for individual hillslopes, channels, and at each watershed outlet. Average annual surface runoff, lateral flow, baseflow, sediment detachment, deposition, and yield, and total phosphorus, soluble reactive phosphorus, and particulate phosphorus are displayed both in tabular (as a text file) and visual (as a shapefile) format for each individual watershed or for multiple watersheds combined. Managers can further use these results to sort and select hillslopes that are generating more runoff and erosion based on specific hillslope attributes such as slope steepness or soil or management type for each simulation scenario. Lastly, we will discuss advantages and disadvantages of using online interfaces for hydrologic modeling and forest management.
Single-Precursor, One-Pot Versatile Synthesis under near Ambient Conditions of Tunable, Single and Dual Band Fluorescing Metal Sulfide Nanoparticles (2003)

We present a simple and versatile method for the synthesis of high-quality size-controlled metal sulfide nanoparticles. A single compound (metal xanthate) is the precursor. A Lewis-base solvent is used to achieve a low reaction temperature of 50-150 degrees C, usually in air. Demonstrated with CdS, the precise control over the particle size (by regulating the temperature or the concentration) enables tuning the absorption and emission spectra of the particles. We also can control the relative intensity of the narrow (30-35 nm wide) excitonic emission (tunable in the range 430-480 nm with approximately 2% fluorescence quantum efficiency) and the broad emission associated with deep surface traps (in the range 550-700 nm). Using the same precursor CdS/ZnS core/shell particles are produced with a high PL yield ( approximately 14%).
(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids (1978)

The introduction of an aryl group at the 2 position of the uricosuric diuretics, (1-oxo-2-alkyl-5-indanyloxy)acetic acids, provided compounds with markedly increased potency over their monosubstituted precursors. These compounds were synthesized either by arylation of the corresponding 2-alkyl-5-methoxy-1-indanones with diaryliodonium salts or by alkylation of the 2-aryl-5-methoxy-1-indanones which were cleaved to the corresponding phenols and then converted to the desired oxyacetic acids. Systematic structural variation of the 2-arylindanyloxyacetic acids provided aryl-substituted compounds with varying degrees of uricosuric and diuretic activity.
VP22.02: MR‐based patient‐specific planning platform for Twin–twin transfusion syndrome surgery (2020)

To evaluate the accuracy and usability of a MR-based patient-specific planning platform for Twin–twin transfusion syndrome (TTTS) surgery. Experimental study including 8 cases of TTTS that were treated in our centre. After standard ultrasound (US) examination to confirm diagnosis and TTTS stage, we obtained T2-weigthed MR images of maternal abdomen in the axial view that were post-processed to obtain a three-dimensional reconstruction of the maternal soft tissue, uterus, placenta, and placental vessels. This model allowed to test different entry points in a simulation environment and in all TTTS cases a simulated insertion point (Sip) was defined by a fetal surgeon. Surgery was performed by fetal surgery expert team (>100 surgeries/year) blinded to the model. After surgery, coordinates of real insertion point (Rip) were obtained considering navel as reference and was compared with Sip. Pre-surgical simulation time was 11:46 minutes (min 7:06; max 15:09). When Sip and Rip were compared, both distances were highly correlated (x-distance R2 = 0.994, p < 0.001; y-distance (R2 = 0.830, p = 0.011)). Median difference in x-distance was 1.37 cm (min 0.36; max 2.33) and 0.58 cm (min 0.27; max2.62) in y-distance. Figure 1 depicts distribution of Sip and Rip. Selection of insertion point using a MR-based patient-specific planning platform showed a good correlation, but some differences, with clinical assessment using US. Application of this platform could improve performance and reduce errors of insertion, reduce variability in difficult cases. Clinical studies to evaluate its impact in clinical practice are warranted. Supporting information can be found in the online version of this abstract Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.