gebhart/patrepeval huggingface dataset:
The influence of cardiopulmonary receptors on long‐term blood pressure control and plasma renin activity in conscious dogs (1987)

The isolated and combined influence of cardiopulmonary and arterial baroreceptor denervation on long-term blood pressure (MAP), heart rate (HR), plasma volume (PV) and plasma renin activity (PRA) was studied in 10 conscious, chronically instrumented foxhounds receiving a normal sodium diet. Cardiopulmonary denervation was achieved by surgically stripping both thoracic vagi. Near complete arterial baroreceptor denervation, leaving most cardiopulmonary fibres intact, was made by left vagal deafferentiation which has been shown to eliminate most aortic baroreceptor afferents, and a carotid sinus denervation. Five groups were studied: (I) control (n = 9), (II) cardiopulmonary denervation (n = 5), (III) aortic baroreceptor denervation (n = 5), (IV) arterial baroreceptor denervation (n = 4) and (V) total denervation (n = 6). No changes in PV were observed. Only group V revealed significantly higher levels of MAP (119.5 +/- 5.4 vs. 100.1 +/- 1.6 mmHg; P less than 0.05), HR (118.1 +/- 4.4 vs. 87.8 +/- 3.7 beats min-1; P less than 0.001) and PRA (3.0 +/- 0.8 vs. 0.9 +/- 0.2 ng AI m-1 h-1; P less than 0.05). It is suggested that the isolated function of either cardiopulmonary or arterial baroreceptors is sufficient to maintain these variables at a normal level. Contrary to the results of other reports the cardiopulmonary receptors do not seem to regulate MAP at a level about which the arterial baroreceptors operate. When both groups of afferents were interrupted MAP, HR and PRA rose to significantly higher levels, implying that cardiopulmonary and arterial baroreceptor afferents interact in a sense of a non-additive attenuation.
An algorithm for sizing trunks carrying mixtures of constant and variable bit rate traffic (1995)

Abstract As new broadband networks based on the asynchronous transfer mode (ATM) protocol emerge to support a variety of services, the need for analytical models and tools for sizing network components carrying mixtures of different kinds of traffic will be increasingly felt. This paper presents a simple, yet efficient algorithm for sizing trunks carrying mixtures of constant and variable bit rate traffic. It combines theoretical results for the multi‐dimensional Erlang model and the concept of equivalent bandwidth with some heuristic arguments to produce an analytic method for sizing trunks subject to blocking and quality of service constraints for traffic classes.
Energy loss reduction by critical switches (1993)

A systematic method to derive an optimal switching plan to achieve energy loss minimization for short term and long term operation of distribution systems is presented. The short term optimal switching criterion is developed by binary integer programming with a branch and bound technique. An overall optimization problem is formulated for the optimal switching operation. It is further divided into several subproblems to find the largest energy loss reduction among all possible switching operations between two feeders. A quick method is applied to estimate the largest loss reduction for each feeder-pair in the distribution system during short term switching operation. The composite load profile of each feeder is derived by field tests over a one year period. After determining the hourly optimal network configuration by taking into the account the typical daily load patterns for all the distributed feeders, the long term optimal criterion for each season is derived and the corresponding critical switches are determined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies (2022)

Several studies have shown that the first encounter with influenza virus shapes the immune response to future infections or vaccinations. However, a detailed analysis of the primary antibody response is lacking as this is difficult to study in humans. It is therefore not known what the frequency and dynamics of the strain-specific hemagglutinin (HA) head- and stem-directed antibody responses are directly after primary influenza virus infection. Here, sera of twelve H1N1<sub>pdm2009</sub> influenza virus-infected cynomolgus macaques were evaluated for HA-head and HA-stem domain antibody responses. We observed an early induction of HA-stem antibody responses, which was already decreased by day 56. In contrast, responses against the HA-head domain were low early after infection and increased at later timepoint. The HA-specific B cell repertoires in each animal showed diverse VH-gene usage with preferred VH-gene and JH-gene family usage for HA-head or HA-stem B cells but a highly diverse allelic variation within the VH-usage. HA-head B cells had shorter CDRH3s and higher VH-gene somatic hyper mutation levels relative to HA-stem B cells. In conclusion, our data suggest that HA-stem antibodies are the first to react to the infection while HA-head antibodies show a delayed response, but a greater propensity to enter the germinal center and undergo affinity maturation.
ChemInform Abstract: Stereoselective Formation of Cyclopropylsilane (II) Through Intramolecular Rearrangement of [(Allyloxy)dimesitylsilyl]lithiums. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Docetaxel and cyclophosphamide as adjuvant chemotherapy for early breast cancer: primary prophylaxis with G-CSF is required (2013)

SUMMARY AIM: To determine the incidence of febrile neutropenia (FN) associated with the use of docetaxel and cyclophosphamide (TC) as adjuvant chemotherapy for early breast cancer (EBC) and also the grade of neutropenia after cycle 1 of TC. METHODS: We conducted a multicenter retrospective audit of women with EBC treated with TC between January 2010 and July 2011, recruited from seven Australian centers. RESULTS: Of a total of 368 previously untreated women with EBC who received TC, 300 were evaluable for FN and 304 were evaluable for neutropenia after cycle 1 of TC. Overall, 73 (24.3%) patients developed FN. The incidence of FN was highest after cycle 1 of TC and was significantly higher in women under 65 years of age (p = 0.007). There was significant variation in the incidence of FN between participating sites (p &lt; 0.001). Eight patients (2.6%) developed grade 3 neutropenia and 191 patients (62.8%) developed grade 4 neutropenia. CONCLUSION: TC as adjuvant chemotherapy for EBC is associated with a 24.3% incidence of FN and a 65.4% incidence of grade 3 or 4 neutropenia. The high incidence of FN and severe neutropenia warrant the use of G-CSF as primary prophylaxis.
ZFlow: Gated Appearance Flow-based Virtual Try-on with 3D Priors (2021)

Image-based virtual try-on involves synthesising perceptually convincing images of a model wearing a particular garment and has garnered significant research interest due to its immense practical applicability. Recent methods involve a two stage process: i) warping of the garment to align with the model ii) texture fusion of the warped garment and target model to generate the try-on output. Issues arise due to the non-rigid nature of garments and the lack of geometric information about the model or the garment. It often results in improper rendering of granular details. We propose ZFlow, an end-to-end framework, which seeks to alleviate these concerns regarding geometric and textural integrity (such as pose, depth-ordering, skin and neckline reproduction) through a combination of gated aggregation of hierarchical flow estimates termed Gated Appearance Flow, and dense structural priors at various stage of the network. ZFlow achieves state-of-the-art results as observed qualitatively, and on quantitative benchmarks of image quality (PSNR, SSIM, and FID). The paper presents extensive comparisons with other existing solutions including a detailed user study and ablation studies to gauge the effect of each of our contributions on multiple datasets.
Convolutional Neural Networks for Sentiment Classification on Business\n Reviews (2017)

Recently Convolutional Neural Networks (CNNs) models have proven remarkable\nresults for text classification and sentiment analysis. In this paper, we\npresent our approach on the task of classifying business reviews using word\nembeddings on a large-scale dataset provided by Yelp: Yelp 2017 challenge\ndataset. We compare word-based CNN using several pre-trained word embeddings\nand end-to-end vector representations for text reviews classification. We\nconduct several experiments to capture the semantic relationship between\nbusiness reviews and we use deep learning techniques that prove that the\nobtained results are competitive with traditional methods.\n
Temporal Trends in the Use of Anticoagulants Among Older Adults With Atrial Fibrillation (1999)

Warfarin use in community-dwelling elderly persons with electrocardiogram-documented atrial fibrillation increased steadily following the first publication of its treatment benefit, reaching 50% by 1996. In contrast, use of aspirin was unchanged during this same period. Continued efforts to promote appropriate anticoagulation therapy to physicians and their patients may still be needed.
Avoiding underdiagnosis, overdiagnosis, and misdiagnosis of lung carcinoma. (2008)

In addition to understanding the clinical context in which a lung biopsy is procured and the radiographic findings, appreciating the histologic distribution of disease and what, if any, pathologic features are present in the background can go a long way toward averting a misdiagnosis of lung cancer. Recognizing the limitations posed by small samples and communicating clearly to clinicians the level of diagnostic uncertainty are equally as important for establishing an accurate diagnosis of lung cancer.
Frontotemporal Lobar Degeneration: Current Concepts in the Light of Recent Advances (2007)

Work done over the past decade has led to a molecular understanding of frontotemporal lobar degeneration (FTLD), a deadly disease that afflicts patients in mid-life. It is a common cause of dementia, second only to Alzheimer's disease in the population below 65 years of age. Neuroanatomical and neurobiological substrates have been identified for the three major subtypes of FTLD and these discoveries have broadened the FTLD spectrum to include amyotrophic lateral sclerosis (ALS). Mutations in MAPT were found to cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), a familial disorder with filamentous tau inclusions in nerve cells and glial cells. FTDP-17 can result in clinical syndromes that closely resemble progressive supranuclear palsy, corticobasal degeneration and Pick's disease. More recently, mutations in three genes (VCP, CHMP2B and PGRN) have been found to cause FTLD with ubiquitin-positive, tau-negative neuronal inclusions (FTLD-U). They explain a large proportion of inherited FTLD-U. It remains to be seen whether dementia lacking distinctive histopathology (DLDH) constitutes a third disease category, as many of these cases are now being reclassified as FTLD-U. Recently, TAR DNA-binding protein-43 (TDP-43) has been identified as a key protein of the ubiquitin inclusions of FTLD-U and ALS. Thus, for familial forms of FTLD and related disorders, we now know the primary etiologies and accumulating proteins. These findings are pivotal for dissecting the pathways by which different etiologies lead to the varied clinicopathological presentations of FTLD.
Direct Spatial Implementation of Sparse Matrix Multipliers for Reservoir Computing (2021)

Reservoir computing systems rely on the recurrent multiplication of a very large, sparse, fixed matrix. We argue that direct spatial implementation of these fixed matrices minimizes the work performed in the computation, and allows for significant reduction in latency and power through constant propagation and logic minimization. Bit-serial arithmetic enables massive static matrices to be implemented. We present the structure of our bit-serial matrix multiplier, and evaluate using canonical signed digit representation to further reduce logic utilization. We have implemented these matrices on a large FPGA and provide a cost model that is simple and extensible. These FPGA implementations, on average, reduce latency by 50x up to 86x versus GPU libraries. Comparing against a recent sparse DNN accelerator, we measure a 4.1x to 47x reduction in latency depending on matrix dimension and sparsity. Throughput of the FPGA solution is also competitive for a wide range of matrix dimensions and batch sizes. Finally, we discuss ways these techniques could be deployed in ASICs, making them applicable for dynamic sparse matrix computations.
GrainScan: a low cost, fast method for grain size and colour measurements (2014)

By using GrainScan, cheap and fast measurement of grain colour and size will enable plant research programs to gain deeper understanding of material, where limited or no information is currently available.
When product designers use perceptually based color tools (2001)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Arthroscopic Fragment Fixation Using Hydroxyapatite/Poly-L-Lactate Acid Thread Pins for Treating Elbow Osteochondritis Dissecans (2015)

Arthroscopic fragment fixation using HA/PLLA thread pins provides a beneficial clinical outcome to adolescent baseball players with humeral capitellar OCD.
Struktur der Marketing-Mixe in der Musik- und Filmindustrie (2004)

Die bisher vorgenommene Systematisierung von Eigenschaften und die strukturierte Erfassung des aktuellen Angebotes machen das aktuelle Angebot und den kurzfristigen Differenzierungsraum einer systematischen Analyse zugänglich: Auf Grundlage dieses Modells sollen zunächst strukturentdeckende329 Verfahren angewandt werden. Im Folgenden wird dies durch eine gruppensuchende Clusteranalyse und verschiedene Vergleichsverfahren zwischen den aktuellen Marketing-Mixen und denen, die Element des kurzfristigen Differenzierungsraumes sind, realisiert.
Silicon-based low-dimensional materials for thermal conductivity suppression: recent advances and new strategies to high thermoelectric efficiency (2020)

Abstract Thermoelectric (TE) materials can convert any kind of heat into electricity through the Seebeck effect. Harvesting body heat and generating electricity by TE wearable devices can provide a convenient charge service for electrical equipment, even in the case of emergency or disaster. As a high-temperature excellent TE material, silicon also exhibits promising room temperature (RT) potential for wearable TE devices due to its safe and mature production line for the semiconductor industry. Aiming to search for solutions for reducing thermal conductivity ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>κ</mml:mi> </mml:math> ), this review summarizes the low-dimensional strategies for reducing <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>κ</mml:mi> </mml:math> based on nanostructural classification, thus enhancing zT at RT, and it also looks into the prospect of wearable application. Following in the footsteps of nanostack (NS), nanowire (NW), nanoporous (NP) and nanocomposite (NC) Si-based TE materials research, we found that the thermal conductivity has been well controlled and that harmonious regulation of the power factor (PF) with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>κ</mml:mi> </mml:math> will be the future direction.
A novel mutation in the PSEN1 gene (L286P) associated with familial early‐onset dementia of Alzheimer type and lobar haematomas (2007)

The aim of this study was to describe a novel mutation in exon 8 of the presenilin gene (L286P) associated with early-onset autosomal dominant Alzheimer's disease (AD) and lobar haematomas. The proband was a woman who developed cognitive decline with predominant memory loss at the age of 35 years. The patient died at the age of 54 years and the neuropathological examination confirmed the diagnosis of AD. Three of her four siblings, one parent and one sibling of her parent had suffered from cognitive decline at ages between 35 and 42 years. Three of them also presented lobar haematomas. The neuropathological examination, available in one of them, disclosed the presence of severe amyloid angiopathy as the cause of the haematoma. The study of PSEN1 gene with single strand conformation polymorphism technique failed to show abnormalities suggestive of mutations. Direct sequencing disclosed the presence of a missense mutation in codon 286 (L286P) in the proband and her already affected descendent, which was absent in the healthy sibling. L286P is a novel mutation in PSEN1 that causes familial early-onset AD and brain haematomas related to amyloid angiopathy.
Effect of bezafibrate and colestyramine in patients with primary hypercholesterolemia. (1987)

40 patients with primary hypercholesterolemia were included in a randomized cross-over trial comparing effects and tolerance of bezafibrate (Cedur) (200 mg t.i.d.) and colestyramine (4 g t.i.d.). Gastrointestinal side-effects led to the discontinuation of colestyramine in 11 patients. No adverse events were observed with bezafibrate. Both drugs had similar effects on total and low density lipoprotein cholesterol (bezafibrate: -15% and -12%, respectively; colestyramine: -10% and -11%, respectively). While the high density lipoprotein-increasing effect of bezafibrate was more marked (+20% vs. +14%), triglycerides and very low density lipoprotein cholesterol were lowered by bezafibrate (-22% and -27%, respectively) and tended to increase with colestyramine (+11% and +10%, respectively). In the light of results of a multicenter primary prevention trial bezafibrate also should have a protective effect on coronary heart disease. This, however, has to be proven in longterm prospective trials.
Power stability and control in optically transparent mesh networks (2008)

We explore the impact of topology, traffic, and amplifier physics on node-to-node channel-power coupling effects in an optically transparent mesh network and describe a simple control strategy for scheduling the adjustment of control elements.
Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif (2018)

Peptide natural products are often used as signals or antibiotics and contain unusual structural modifications, thus providing opportunities for expanding our understanding of Nature's therapeutic and biosynthetic repertoires. Herein, we have investigated the under-explored biosynthetic potential of Streptococci, prevalent bacteria in mammalian microbiomes that include mutualistic, commensal, and pathogenic members. Using a new bioinformatic search strategy, in which we linked the versatile radical S-adenosylmethionine (RaS) enzyme superfamily to an emerging class of natural products in the context of quorum sensing control, we identified numerous, uncharted biosynthetic loci. Focusing on one such locus, we identified an unprecedented post-translational modification, consisting of a tetrahydro[5,6]benzindole cyclization motif in which four unactivated positions are linked by two C-C bonds in a regio- and stereospecific manner by a single RaS enzyme. Our results expand the scope of reactions that microbes have at their disposal in concocting complex ribosomal peptides.
Replication techniques for speeding up parallel applications on distributed systems (1992)

Abstract Most methods for programming loosely coupled systems are based on message‐passing. Recently, however, methods have emerged based on ‘virtually’ sharing data. These methods simplify distributed programming, but are hard to implement efficiently, as loosely coupled systems do not contain physical shared memory. We introduce a new model, the shared data‐object model , that eases the implementation of parallel applications on loosely coupled systems, but can still be implemented efficiently. In our model, shared data are encapsulated in passive data‐objects, which are variables of user‐defined abstract data types. To speed up access to shared data, data‐objects are replicated. This ability to replicate objects is a significant difference with other object‐based models (e.g. Emerald and Amber). Also, by replicating logical objects rather than physical pages, our model has many advantages over shared virtual memory systems. This paper discusses the design choices involved in replicating objects and their effect on performance. Important issues are: how to maintain consistency among different copies of an object; how to implement changes to objects; which strategy for object replication to use. We have implemented several options to determine which ones are the most efficient.
Photodynamic Therapy with Pyropheophorbide-a Methyl Ester in Human Lung Carcinoma Cancer Cell: Efficacy, Localization and Apoptosis¶ (2002)

Pyropheophorbide-a methyl ester (MPPa) is a semisynthetic photosensitizer derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay showed that MPPa had no dark cytotoxicity. In vitro photodynamic activity was extensively evaluated using a human lung carcinoma cancer cell line (NCI-h446). MPPa exhibited no genotoxicity, as assayed by single-cell gel electrophoresis. Using confocal laser scanning microscopy and organelle-specific fluorescent probes, MPPa was found to localize in the intracellular membrane system, namely the endoplasmic reticulum, Golgi apparatus, lysosomes and mitochondria, in the NCI-h446 cells. Furthermore, nuclear staining and DNA gel electrophoresis revealed that DNA condensation and fragmentation occurred post-photodynamic therapy, indicating the cell death was in the apoptotic mode.
ChemInform Abstract: Inhibitors of Proteases and Amide Hydrolases that Employ an α‐Ketoheterocycle as a Key Enabling Functionality (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a new optical scale system by the diffractive phase interference method (1995)

A new optical scale system developed by the diffractive phase interference method is proposed. The diffractive optics composed of a high-density grating can steer the beam's direction and generate the Doppler phase shift of the moving object. The interference optics, composed of two laser beams, a lambda /4 waveplate and a polarization beam splitter, can provide high resolution and the sign of the Doppler phase shift. From the experimental results, the system has the following characteristics: displacement resolution as high as 0.1 mu m, critical direction discrimination ability, excellent linearity with error less than 6 ppm and high stability with drift less than 0.9 mu m.