gebhart/patrepeval huggingface dataset:
In situ observation of ErD 2 formation during D 2 loading via neutron diffraction (2011)

In an effort to better understand the structural changes occurring during hydrogen loading of erbium target materials, we have performed in situ D 2 loading of erbium metal (powder) at temperature (450°C) with simultaneous neutron diffraction analysis. This experiment tracked the conversion of Er metal to the α erbium deuteride (solid-solution) phase and then into the β (fluorite) phase. Complete conversion to ErD 2.0 was accomplished at 10 Torr D 2 pressure with deuterium fully occupying the tetrahedral sites in the fluorite lattice.
Hypopigmentation Associated With an Adenovirus-Mediated gp100/MART-1–Transduced Dendritic Cell Vaccine for Metastatic Melanoma (2002)

We provide the initial evidence for effective induction of a leukodermic response with a gp100/MART-1-transduced dendritic cell vaccine.
Impact of insulin therapy on insulin resistance and a risk for coronary heart disease and cardiovascular death in patients with type 2 diabetes (2010)

Aim. To evaluate the impact of insulin therapy in combination with oral sugar-reducing drugs (OSRD) on metabolic control and a risk for coronary heart disease (CHD) and a 10-year cardiovascular death risk in patients with type 2 diabetes (T2D). Subjects and methods. Seventy-four patients (49 women and 25 men) aged 36-78 years (mean 56.28 ± 2.58 years) with a 9.34 ± 1.12-year history of T2D were examined. The investigators made a clinical examination, studied the parameters of carbohydrate metabolism: glycated hemoglobin (HbA1c), fasting (FG) and postprandial glycemia (PPG) (2 hours after meals) and lipid metabolism, insulin resistance, microalbuminuria (MAU), and combined therapy-induced blood pressure changes. The risk for CHD was estimated from the atherogenicity index, total cholesterol/high-density lipoproteins and low-density lipoproteins/high-density lipoproteins ratios, and SCORE index. Results. Long-term insulin therapy in combination with OSRD caused a significant improvement in carbohydrate metabolism (reductions in HbA1c by 216-23.2%, FG and PPG by 33.4-35.7%), positive lipid metabolic changes, a decrease in MAU by 0.12 ± 0.03 to 0.03 ± 0.01 g/l, with a fall of its detection rate from 73 to 27%; a considerable decline in IR from the HOMA and CARO indices (by 30-32%), as well as a significant reduction in the risk for CHD and 10-year cardiovascular death risk from the SCORE index (from 4 to 1.5-1.6%; p < 0.01). Conclusion. Combined therapy with long-acting insulin in combination with OSRD in patients with T2D resulted in metabolic improvement and a significant reduction in the risk for CHD and 10-year cardiovascular death risk.
THE SPECIFIC HEAT OF A FERMI GAS AT LOW TEMPERATURE: A CLOSER LOOK AT THE lnT BEHAVIOR (1999)

At finite temperature, a Fermi gas can have states that simultaneously hold a particle and a hole with a finite probability. This gives rise to a new set of diagrams that are absent at zero temperature. The so called "anomalous" diagram is just one of the new diagrams. We have already studied the contribution of these new diagrams to the thermodynamic potential (Phys. Lett.A224, 127 (1996)). Here we continue that work and calculate their effect on the specific heat. We will also calculate the finite temperature contribution of the ring diagrams. We conclude that the ln T behavior of the specific heat due to exchange gets canceled by the new contribution of the new diagrams, and that screening is not essential to resolve this anomaly.
Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3‐D approach (2014)

Antimicrobial resistance is a global challenge that impacts both human and veterinary health care. The resilience of microbes is reflected in their ability to adapt and survive in spite of our best efforts to constrain their infectious capabilities. As science advances, many of the mechanisms for microbial survival and resistance element transfer have been identified. During the 2012 meeting of Antimicrobial Agents in Veterinary Medicine (AAVM), experts provided insights on such issues as use vs. resistance, the available tools for supporting appropriate drug use, the importance of meeting the therapeutic needs within the domestic animal health care, and the requirements associated with food safety and food security. This report aims to provide a summary of the presentations and discussions occurring during the 2012 AAVM with the goal of stimulating future discussions and enhancing the opportunity to establish creative and sustainable solutions that will guarantee the availability of an effective therapeutic arsenal for veterinary species.
Penile ulcer in heroin abuse: a case report. (1982)

The rarity of reported cases of cutaneous ulcerations in heroin abusers prompts this report of a 25-year-old man with a painless, slightly necrotic and purulent ulcer of the dorsal shaft of the penis. The differential diagnosis of the lesion and cutaneous manifestations of heroin abuse are reviewed. To our knowledge, this is only the second reported case of penile ulcer from heroin injection.
Molecular structure of dichloro(1,4,7-triazacyclononane)copper(II), a macrocyclic triamine complex with an unusually small formation constant (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structure of dichloro(1,4,7-triazacyclononane)copper(II), a macrocyclic triamine complex with an unusually small formation constantWilliam F. Schwindinger, Timothy G. Fawcett, Roger A. Lalancette, Joseph A. Potenza, and Harvey J. SchugarCite this: Inorg. Chem. 1980, 19, 5, 1379–1381Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ic50207a054https://doi.org/10.1021/ic50207a054research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Methods Utilized in Treating Lateral Epicondylitis (2000)

AbstractAbstractLateral epicondylitis is a common condition treated by many physical therapists. Although multiple treatment methods exist, scientific research has found that few have been consistently effective in treating lateral epicondylitis. Initially, lateral epicondylitis is often treated with rest, ice, braces and/or injections. When the condition is chronic or not responding to initial treatment, physical therapy is introduced. Common therapeutic modalities often utilized are ultrasound, phonophoresis, electric stimulation, manipulation, soft tissue mobilization, neural tension, friction massage, ASTM AdvantEDGE™, in addition to stretching and strengthening exercises. ASTM AdvantEDGE™ is becoming a more standard treatment process owing to its ability to help with the detection in changes in the soft tissue texture as the patient progresses through the therapeutic process. Laser and acupuncture are also becoming more popular. Finally, in resistant cases of lateral epicondylitis, patients can receive surgery. In all, there are over 40 different treatment methods reported in the literature. Further research efforts are needed to determine which methods are most effective.
Recessive and sex-dependent genetic effects in primary hypertension (2022)

ABSTRACT Background Essential hypertension is a polygenic disease that affects almost half of the adult population in the USA. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases. Previous studies used UK-Biobank (UKB) GWAS results for hypertension to create a polygenic risk score (PRS), with the top and bottom 5% of the PRS translating to a 4-fold difference in the estimated risk. The heritability of hypertension is estimated to be high (30–60%), yet the underlying mechanisms and the associated genes are largely unknown. Methods In this study, we used a gene-based method, the proteome-wide association study (PWAS), to detect associations mediated by the effects of variants on protein function. PWAS was applied to individuals of European ancestry from the UKB, with 74,090 cases of clinical diagnosis of essential (primary) hypertension (ICD-10, I10) and 200,734 controls. PWAS aggregates the signal from all variants affecting each coding gene and provides scores for dominant, recessive, and hybrid genetic heritability. Results PWAS identified 70 statistically significant associated genes (FDR-q-value &lt;0.05) and 127 genes with a weaker threshold (FDR-q-value &lt;0.1). The overlap with GWAS summary statistics (total 1,362 genes) is only partial, with 23 and 62 genes identified exclusively by PWAS from a total of 70 and 127 genes, respectively), among them 18% were assigned recessive inheritance. Furthermore, PWAS analysis, separately performed on females and males from UKB genotyping imputed data, revealed sex-dependent genetics. There are 22 genes unique in females, with only 2 in males. We identified 6 female-specific genes that were not identified by PWAS for the entire group (70 genes). Only one associated gene (SH2B3) is shared between the sexes. Many of the female-significant genes from PWAS are enriched in cellular immunity functions. Conclusions We conclude that hypertension displays sex-dependent genetics with an overlooked recessive inheritance, postulating that the underlying mechanism is substantially different for males and females. Studying hypertension by a gene-based association method improves interpretability and clinical utility.
Rate, Causes, and Clinical Implications of Presenting with Low CD4 + Cell Counts in the Era of Highly Active Antiretroviral Therapy (2003)

Of patients attending HIV clinics, neither the proportion with CD4(+) cell counts below 200 cells/microl, and therefore at risk for developing opportunistic infections (OIs), nor the reasons for the persistence of low CD4(+) cell counts are well known in the era of highly active antiretroviral therapy (HAART). In an effort to gather data concerning this issue, the charts of all outpatients who attended two reference HIV clinics in Spain throughout the year 2001 were retrospectively reviewed. Of 1897 subjects, 213 (11%) had at least one CD4(+) cell count determination below 200 cells/microl during 2001. The main reasons for presenting with low CD4(+) cell counts were as follows: (1) poor treatment adherence, 64 (30%); (2) poor immune recovery despite complete virus suppression for longer than 1 year on HAART, 47 (22%); (3) virologic failure under HAART, 33 (15%); (4) no antiretroviral therapy, 23 (11%); (5) initiation of HAART within the current year in subjects with very low CD4(+) cell counts, 17 (8%); (6) impediment in using HAART due to toxicity, 17 (8%); and (7) drug-induced myelotoxicity, 12 (6%). During the period under review, one or more OIs developed in 52 of the 213 (24%) patients with low CD4(+) cell counts. They occurred more frequently in subjects who were naive for antiretroviral drugs or who initiated therapy recently (RR, 6.45; 95% CI, 2.43-17.12; p < 0.001), and conversely tended to be less frequent among subjects with poor immune reconstitution despite complete virologic suppression while on HAART (RR 0.86; 95% CI, 0.28-2.62; p = 0.79). A lower lifetime CD4(+) cell count nadir was associated with a greater risk of developing an OI (RR, 0.98; 95% CI, 0.97-0.99; p < 0.001). We conclude that, despite the availability of HAART, more than 10% of patients currently attending HIV clinics have CD4(+) cell counts <200 cells/microl, and continue to be at risk for developing OIs. Poor treatment adherence and lack of immune recovery despite complete virus suppression while on HAART account for more than half of cases.
Flip chip assembly for sub-millimeter wave amplifier MMIC on polyimide substrate (2014)

The sub-millimeter wave amplifier MMIC with flip-chip mounting on polyimide substrate has been realized. The thickness of the substrate and the pitch of GND vias are designed to suppress the air radiation from the slot pattern in the substrate. The test results of the micro-strip line formed on the polyimide substrate shows that the design is applicable to the assembly operated up to 320 GHz. The InP HEMT amplifier MMIC with the assembling technique achieved the operation in 240-260 GHz frequency band with the gain of 20 dB.
COVID-19: Insights into long-term manifestations and lockdown impacts (2023)

Coronaviruses are pathogens thought to primarily affect the respiratory tracts of humans. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 was also marked mainly by its symptoms of respiratory illness, which were named coronavirus disease 2019 (COVID-19). Since its initial discovery, many other symptoms have been linked to acute SARS-CoV-2 infections as well as to the long-term outcomes of COVID-19 patients. Among these symptoms are different categories of cardiovascular diseases (CVDs), which continue to be the main cause of death worldwide. The World Health Organization estimates that 17.9 million people die from CVDs each year, accounting for ∼32% of all deaths globally. Physical inactivity is one of the most important behavioral risk factors for CVDs. The COVID-19 pandemic has affected CVDs as well as the physical activity in different ways. Here, we provide an overview of the current status as well as future challenges and possible solutions.
Retinal Complications After Aqueous Shunt Surgical Procedures for Glaucoma (1996)

Aqueous shunt procedures may be associated with significant retinal complications and subsequent visual loss.
Reminiscence of Classical Chaos in Driven Transmons (2023)

International audience
Effect of a Dual Drug-Coated Stent With Abciximab and Alpha-Lipoic Acid in a Porcine Coronary Restenosis Model (2011)

Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.
Parallel Graph Partitioning for Complex Networks (2015)

Processing large complex networks like social networks or web graphs has recently attracted considerable interest. To do this in parallel, we need to partition them into pieces of about equal size. Unfortunately, previous parallel graph practitioners originally developed for more regular mesh-like networks do not work well for these networks. This paper addresses this problem by parallelizing and adapting the label propagation technique originally developed for graph clustering. By introducing size constraints, label propagation becomes applicable for both the coarsening and the refinement phase of multilevel graph partitioning. We obtain very high quality by applying a highly parallel evolutionary algorithm to the coarsest graph. The resulting system is both more scalable and achieves higher quality than state-of-the-art systems like ParMetis or PT-Scotch. For large complex networks the performance differences are very big. As an example, our algorithm partitions a web graph with 3.3G edges in 16 seconds using 512 cores of a high-performance cluster while producing a high quality partition -- none of the competing systems can handle this graph on our system.
The effect of neuroleptic derivatives of butyrophenone on the uptake of 5-HT by human blood platelets (1978)

Journal Article The effect of neuroleptic derivatives of butyrophenone on the uptake of 5-HT by human blood platelets Get access G F Oxenkrug G F Oxenkrug Laboratory of Psycho-pharmacology, Bekhterev Psychoneurological Research Institute, Lenin grad C-19, ul. Bekhterereva 3, U.S.S.R Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 30, Issue 1, September 1978, Page 740, https://doi.org/10.1111/j.2042-7158.1978.tb13383.x Published: 12 April 2011 Article history Received: 20 February 1978 Published: 12 April 2011
Anion Recognition by 1,3-Benzenedisulfonamide Derivatives Bearing Phenolic Hydroxy Groups in MeCN-d3 (2005)

Abstract The halide anion recognition by 1,3-benzenedisulfonamides derived from 2-aminophenols was studied by 1H NMR titrations in MeCN-d3. The results demonstrated that the receptors achieved high recognition ability with chloride anion.
Use of Modified Colloids and Membranes to Remove Metal Ions from Contaminated Solutions (2018)

An efficient process was developed allowing the removal of metal ions from polycontaminated aqueous solutions by combining modified colloids and membranes. Firstly, filtration experiments were performed using polyethersulfone membranes modified by a self-assembled multilayer film of polyelectrolytes. These polymer-modified membranes allowed the uptake of more than 90% of the metal ions initially present in the contaminated solutions (for solutions concentrated at 50 mg L−1). Secondly, adsorption experiments were carried out with colloidal silica encapsulated with carboxymethyl chitosan (SiO2-CMCS) or with mesoporous silica functionalized by grafting of 1,4,8,11-tetraazacyclotetradecane, i.e., cyclam (SiO2-cyclam). The adsorption capacity of these compounds was shown to be higher than numerous other literature-known adsorbents, reaching 68 and 61 mg g−1 towards Cu(II) for SiO2-CMCS and SiO2-cyclam, respectively. Finally, by coupling adsorption with ultrafiltration in the tangential mode, the removal of Cu(II), Ni(II) and Zn(II) ions was found to be improved, allowing to reach a removal efficiency of 99% towards Cu(II), Ni(II) and Zn(II) ions at a metal concentration of 50 mg L−1, and a promising removal efficiency around 70% at a very high metal concentration of 1200 mg L−1. The mechanisms involved in the capture of the metal ions by modified membranes and colloids are also discussed.
A layered and distributed approach to platform systems control (2003)

With the increasing complexity of platform systems and the ongoing demand for reduced manning comes the need for novel approaches to ship control systems. Current control and management systems fall short on maintainability, robustness and scalability. From the operator's perspective information handling has become a demanding task due to the multitude of alarms and data available. To deal with these issues, the Maritime Command &amp; Control group of TNO-FEL pursues a distributed and layered approach to damage &amp; platform control with particular attention to alarm-management. At the lowest level a multi-agent organization is responsible for immediate emergency response. The reactive and adaptive nature of this layer ensures quick isolation of faults and helps to preserve the system's functional integrity. On a higher level the situation is assessed more in depth so that recovery plans can be formulated. The top level provides the user with control options and means to express specific demands from the operational context. By joining the various parts of the architecture in a subsumption-like manner a robust and scalable system is created. To demonstrate these principles a software prototype for a watercooling system aboard navy frigates is being developed for the Royal Dutch Navy.
Segmenting thalamic nuclei from manifold projections of multi-contrast MRI (2023)

The thalamus is a subcortical gray matter structure that plays a key role in relaying sensory and motor signals within the brain. Its nuclei can atrophy or otherwise be affected by neurological disease and injuries including mild traumatic brain injury. Segmenting both the thalamus and its nuclei is challenging because of the relatively low contrast within and around the thalamus in conventional magnetic resonance (MR) images. This paper explores imaging features to determine key tissue signatures that naturally cluster, from which we can parcellate thalamic nuclei. Tissue contrasts include T1-weighted and T2-weighted images, MR diffusion measurements including FA, mean diffusivity, Knutsson coefficients that represent fiber orientation, and synthetic multi-TI images derived from FGATIR and T1-weighted images. After registration of these contrasts and isolation of the thalamus, we use the uniform manifold approximation and projection (UMAP) method for dimensionality reduction to produce a low-dimensional representation of the data within the thalamus. Manual labeling of the thalamus provides labels for our UMAP embedding from which k nearest neighbors can be used to label new unseen voxels in that same UMAP embedding. N -fold cross-validation of the method reveals comparable performance to state-of-the-art methods for thalamic parcellation.
Stimulated Raman adiabatic passage with trains of weak pulses* (2022)

Abstract We consider coherent population transfer in multilevel quantum systems driven by time-delayed pulse trains. We show how to choose the parameters of the trains so that the population dynamics tracks the behavior of a Λ-type three-level system under stimulated Raman adiabatic passage (STIRAP). Efficient population transfer can be achieved regardless of the order and with or without overlap of the pump and the Stokes sub-pulses of the trains. Generalized STIRAP schemes of population transfer in N -level system with sequential couplings are also examined. The mechanism of the population transfer and the robustness of the proposed schemes are discussed.
Comparison of Charge‐Carrier Transport in Thin Films of Spiro‐Linked Compounds and Their Corresponding Parent Compounds (2006)

Abstract The charge‐transport properties of the spiro‐linked compounds 2,2′,7,7′‐tetrakis(diphenylamino)‐9,9′‐spirobifluorene, 2,2′,7,7′‐tetrakis( N , N ′‐di‐ p ‐methylphenylamino)‐9,9′‐spirobifluorene, 2,2′,7,7′‐tetra( m ‐tolyl‐phenylamino)‐9,9′‐spirobifluorene, and 2,2′,7,7′‐tetra( N ‐phenyl‐1‐naphthylamine)‐9,9′‐spirobifluorene, and their corresponding parent compounds, N , N , N ′, N ′‐tetraphenylbenzidine, N , N , N ′, N ′‐tetrakis(4‐methylphenyl)benzidine, and N , N ′‐bis(3‐methylphenyl)‐(1,1′‐biphenyl)‐4,4′‐diamine, N , N ′‐diphenyl‐ N , N ′‐bis(1‐naphthyl)‐1,1′‐biphenyl‐4,4′‐diamine, are investigated. The field‐effect mobilities of charge carriers in thin films of the parent compounds are slightly higher than those of the spiro‐linked compounds. However, the transistor action of the parent‐compound thin films vanishes because the films crystallize after being stored in ambient atmosphere for a few days. In contrast, the hole mobilities in thin films of the spiro‐linked compounds do not change significantly after the samples are stored in ambient atmosphere for up to nine months. Also discussed is the temperature dependency of the mobilities of charge carriers, which is presented using two models, namely the Arrhenius and the Gaussian disorder models.