gebhart/patrepeval huggingface dataset:
Specific Serine-Proline Phosphorylation and Glycogen Synthase Kinase 3β-directed Subcellular Targeting of Stathmin 3/Sclip in Neurons (2012)

During nervous system development, neuronal growth, migration, and functional morphogenesis rely on the appropriate control of the subcellular cytoskeleton including microtubule dynamics. Stathmin family proteins play major roles during the various stages of neuronal differentiation, including axonal growth and branching, or dendritic development. We have shown previously that stathmins 2 (SCG10) and 3 (SCLIP) fulfill distinct, independent and complementary regulatory roles in axonal morphogenesis. Although the two proteins have been proposed to display the four conserved phosphorylation sites originally identified in stathmin 1, we show here that they possess distinct phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regulated by phosphorylation by proline-directed kinases involved in the control of neuronal differentiation. ERK2 or CDK5 phosphorylate the two proteins but with different site specificities. We also show for the first time that, unlike stathmin 2, stathmin 3 is a substrate for glycogen synthase kinase (GSK) 3β both in vitro and in vivo. Interestingly, stathmin 3 phosphorylated at its GSK-3β target site displays a specific subcellular localization at neuritic tips and within the actin-rich peripheral zone of the growth cone of differentiating hippocampal neurons in culture. Finally, pharmacological inhibition of GSK-3β induces a redistribution of stathmin 3, but not stathmin 2, from the periphery toward the Golgi region of neurons. Stathmin proteins can thus be either regulated locally or locally targeted by specific phosphorylation, each phosphoprotein of the stathmin family fulfilling distinct and specific roles in the control of neuronal differentiation.
A new integrated monocycle generator and transmitter for ultra-wideband (UWB) communications (2005)

In this paper, we propose a gated pulse generator incorporating two modulation schemes for use in an ultra-wideband impulse radio system. A pseudo-noise sequence prescaler modulates the impulses with specific modulation schemes, such as pulse position, bi-phase modulation or the combination of both. The resulting gated monocycle generator is designed in Jazz Semiconductor BiCMOS SiGe technology. Measurements validate the circuit operation over a supply voltage of 2.7 V and a power consumption of 243 mW. The output monocycles approximate Gaussian monocycles, having a pulse duration of 250 ps. Proper modulations in time are confirmed.
Virtual screening of gene expression regulatory sites in non-coding regions of the infectious salmon anemia virus (2014)

The information obtained in this work allowed the proposal of previously unknown sites that are involved in the regulation of different stages of the viral cycle, leading to the identification of new viral targets that may assist future antiviral strategies.
Haptic chameleon (2004)

In this paper, we introduce the concept of shape-changing, user interface control devices called "Haptic Chameleon", which refers to computer-controlled user interface devices that convey information to and from the user by altering their shape and feel. The user decides what a Haptic Chameleon control will do by changing its shape, and can immediately recognize the capabilities of the newly shaped device through haptic and tactile channels. By combining the benefits of tangible and haptic user interfaces, this new user interface paradigm has the potential to vastly improve the learning and efficiency of interaction in a wide range of applications. It also represents an appealing alternative to current control devices. We report on our experience with early prototypes based on this concept, discuss open issues, and propose possible directions for future work.
Litho scenario solutions for FinFET SRAM 22nm node (2009)

For the development of the most cost effective lithographic solutions for the 22nm node, the lithographic process and relevant requirements on CDU and overlay need to be identified. In this work, 22nm logic SRAM is selected as use case because FinFET SRAM cells are considered to be a potential successor to conventional planar transistors for 22nm node chips. We focus on the back-end layers of FinFET SRAM, including metal and contact. Litho solutions simulated under ideal scanner conditions with the ASML Brion Tachyon<sup>TM</sup> SMO product are shown. This tool co-optimizes a pixilated freeform source and a continuous transmission gray tone mask based on merit functions of edge placement error. Per scenario, these simulations result in a set of preferred litho solutions with respective source and mask. These solutions have to comply with an imaging metric characterized by MEEF and common PW based on typical fab requirements. In a second step the previously generated solutions are evaluated for CDU analysis using realistic scanner error budget. The purpose is to predict the CDU performance of scanner, process and reticle in order to identify the major contributors for every scenario solution.
Monitoring bacterial faecal contamination in waters using multiplex real-time PCR assay for Bacteroides spp. and faecal enterococci (2010)

Monitoring of sanitary quality or faecal pollution in water is currently based on quantifying some bacterial indicators such as Escherichia coli and faecal enterococci. Using a multiplex real-time PCR assay for faecal enterococci and Bacteroides spp., the detection of faecal contamination in non-treated water can be done in a few hours, reducing the analysis time to 2 h. The conventional method based on cultures was compared with a multiplex assay procedure for Bacteroides spp. and faecal enterococci with an internal inhibition control. Out of 74 water samples from different sources analyzed, using both procedures, 54 were true positives and 6 true negatives, 12 samples were real-time PCR positive and culture-negative whereas 2 were real-time PCR negative and culture-positive. In conclusion, 89.2% of the samples were found to be positive with real-time PCR and 75.7% with plate cultures. Detection levels were much higher when using the multiplex real-time PCR assay, based on the higher number of positive samples in comparison with conventional microbiology. The feasibility of multiple reactions in the monitoring of faecal contamination has been demonstrated along with fast quantification of the faecal load. Such procedure can be performed in less than 3 h. This work extends the use of multiplex real-time PCR for environmental analysis, demonstrating the feasibility of these procedures in monitoring faecal pollution of water samples.Keywords: faecal contamination, multiplex real-time PCR, water monitoring, faecal enterococci, Bacteroides spp.
New water-soluble hydrogen donors for the enzymatic photometric determination of hydrogen peroxide. II. N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline derivatives. (1982)

Five N-ethyl-N-(2-hydroxy-3-sulfopropyl) aniline derivatives have been synthesized and assessed as water-soluble hydrogen donors for the photometric determination of hydrogen peroxide in the presence of peroxidase. These compounds, sodium salts of N-ethyl-N-(2-hydroxy-3-sulfopropyl) aniline, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-m-toluidine, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-m-anisidine, 3, 5-dimethyl-N-ethyl-N-(2-hydroxy-3-sulfopropyl) aniline and 3, 5-dimethoxy-N-ethyl-N-(2-hydroxy-3-sulfopropyl)-aniline, gave high absorbances at visible wavelengths in media in the weakly alkaline to fairly acidic pH range. Further, the urea adduct of hydrogen peroxide could be conveniently used as a standard material.
ChemInform Abstract: Synthesis and Characterization of a New 26π‐Aromatic Thiophene‐ Containing Macrocyclic Ligand. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intercept-resend attacks in the Bennett-Brassard 1984 quantum-key-distribution protocol with weak coherent pulses (2005)

Unconditional security proofs of the Bennett-Brassard 1984 protocol of quantum key distribution have been obtained recently. These proofs cover also practical implementations that utilize weak coherent pulses in the four signal polarizations. Proven secure rates leave open the possibility that new proofs or new public discussion protocols will obtain larger rates over increased distance. In this paper we investigate limits to the error rate and signal losses that can be tolerated by future protocols and proofs.
Ocular Features of Kawasaki's Disease (1982)

• Ocular signs are a principal presenting feature of Kawasaki's disease. It is important for the ophthalmologist to recognize the hyperemic, indurated limbalsparing inflammation, since sudden death occurs in 1% to 2% of the patients and the reported incidence is increasing.
Editorial: Special Issue on Data Transparency—Data Quality, Annotation, and Provenance (2022)

opinion Share on Editorial: Special Issue on Data Transparency—Data Quality, Annotation, and Provenance Authors: Mahmoud Barhamgi Claude Bernard University Lyon 1, Villeurbanne, France Claude Bernard University Lyon 1, Villeurbanne, FranceSearch about this author , Elisa Bertino Purdue University, West Lafayette, United States Purdue University, West Lafayette, United StatesSearch about this author Authors Info & Claims Journal of Data and Information QualityVolume 14Issue 1March 2022 Article No.: 1pp 1–3https://doi.org/10.1145/3494454Online:02 February 2022Publication History 0citation141DownloadsMetricsTotal Citations0Total Downloads141Last 12 Months141Last 6 weeks25 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Curing behavior, mechanical properties, intermolecular interaction, and morphology of silicone/polypyrrole/polymer electrolyte composites (2006)

Abstract The curing behavior, mechanical properties, intermolecular interaction, and morphology of silicone, polypyrrole, and polymer electrolyte composites were studied. A rigid‐body pendulum rheometer was used to determine the curing behavior of silicone/PEL blends. The polymer structure was evaluated using FTIR and Differential Scanning Calorimetery. The mechanical properties, including stress, strain, and hardness, were measured using a material testing system. The morphology of the composites was measured using scanning electron micrographs. The intermolecular interaction of the composites was measurement using dynamic mechanical analysis. The results show that the curing reaction rate is fast upon addition of 10 wt % of polymer electrolyte for silicone. The linear molecular structure of the polymer electrolyte was wound around the silicone polymer network structure forming a semi‐interpenetrating network. The intermolecular interaction was influenced by the composites, and the Ppy film effect on the surface of SP10 blends is more uniform than that of silicone. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 2754–2764, 2006
Abstract 3418: Additional mutation in PTPN11 gene promotes tumorigenesis of the NF1 gene mutated cells (2017)

Abstract The NF1 tumor suppressor gene encodes neurofibromin and is a functional Ras GTPase-activating protein (RasGAP) involved in negatively regulating the Ras signal by accelerating the conversion of activated Ras-GTP to inactive Ras-GDP. NF1 gene germline mutations cause Neurofibromatosis type 1 (NF1, von Recklinghausen disease). We hypothesized that additional genetic alterations promote the malignancy of NF1-associated tumors. To test our hypothesis, we inoculated a GFP-labeled human NF1-deficient cell line, sNF96.2-GFP, which has a frame-shift mutation (c.3683delC, p.Asn1229MetfsTer11) in the NF1 gene, into the renal sub-capsules of immunodeficient mice. A subclonal cell line, the A-1 cell, was established from the developed tumor. We found that A-1 cells show much higher tumorigenic activity and phosphorylation status of MEK and Akt than the parental sNF96.2-GFP cells. We analyzed the genomic DNA of both the sNF96.2 and the A-1 cells by using the next-generation sequencing and our medical exome panel of 4813 genes, which are known to be responsible for most human genetic disorders. We identified 18 heterozygous variants within coding regions of 17 genes that were present in the A-1 cells, but not in the original sNF96.2 cells. We found a single base substitution (c.1508G&amp;gt;T, p.Gly503Val) in the PTPN11 gene, which encodes the tyrosine phosphatese SHP-2, and is associated with the regulation of the Ras signaling pathway. It is critical to note that constitutional gain-of-function mutations in the PTPN11 gene cause Noonan Syndrome in humans due to activation of the Ras pathway. To determine the role of PTPN11 mutation in NF1-associated tumors, we established a cell line overexpressing PTPN11mut in sNF96.2-GFP cells. We inoculated parental cells and PTPN11mut cells into the subcutaneous of nude mice, and we found that PTPN11mut cells show much higher tumorigenic activity than the parental sNF96.2-GFP cells. Our data suggests that this additional gene mutation in PTPN11 promotes the malignant characteristics of NF1-associated tumors. Citation Format: Yoshimi Arima, Ritsuko Harigai, Ryo Sato, Toshiki Takenouchi, Kenjiro Kosaki, Hideyuki Saya. Additional mutation in PTPN11 gene promotes tumorigenesis of the NF1 gene mutated cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3418. doi:10.1158/1538-7445.AM2017-3418
The Professor of Management: The Academy of Management and Professionalism. (1971)

The subject of this paper is the relationship of the Academy of Management to the profession of management. Its purpose is to explain some of the reasons for our reorganization within the Academy and to suggest directions for the future. First, let us review what has been happening in the Academy. The last year witnessed a significant reorganization. Underlying these changes was the philosophy that as an Academy we must provide professional services for our members! These members, traditionally, are professors of management. Although we have increased the number of executive members significantly, we still have 90 percent academics as members. Due to the nature of the training for academic life, many of the younger men have been weak or lacking in direct contact with the world of work. Because of this their teaching is apt to be sterile. Personally, I am convinced that the gestaltists such as Wertheimer and Lewin were correct. Namely, much of the learning of the skills of management involves subtle processes which can best be achieved by direct experience and involvement. Most of us are perceptually rather than conceptually oriented. We have to experience things first before we can understand them. Thus, we have seen as an important function of the Academy of Management the provision of avenues for bringing professors into direct contact with the world of
Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population (2020)

While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for metabolic traits. Determining the transferability of such largely Euro-centric established risk loci is essential to transfer the research tools/resources, and drug targets generated by global studies to a broad range of ethnic populations. Further, consideration of populations such as Arabs, that are characterized by consanguinity and a high level of inbreeding, can lead to identification of novel risk loci. We imputed published GWAS data from two Kuwaiti Arab cohorts (n = 1434 and 1298) to the 1000 Genomes Project haplotypes and performed meta-analysis for associations with 13 metabolic traits. We compared the observed association signals with those established for metabolic traits. Our study highlighted 70 variants from 9 different genes, some of which have established links to metabolic disorders. By relaxing the genome-wide significance threshold, we identified 'novel' risk variants from 11 genes for metabolic traits. Many novel risk variant association signals were observed at or borderline to genome-wide significance. Furthermore, 349 previously established variants from 187 genes were validated in our study. Pleiotropic effect of risk variants on multiple metabolic traits were observed. Fine-mapping illuminated rs7838666/CSMD1 rs1864163/CETP and rs112861901/[INTS10,LPL] as candidate causal variants influencing fasting plasma glucose and high-density lipoprotein levels. Computational functional analysis identified a variety of gene regulatory signals around several variants. This study enlarges the population ancestry diversity of available GWAS and elucidates new variants in an ethnic group burdened with metabolic disorders.
Layout-dependent-effects-aware analytical analog placement (2015)

Layout-dependent effects (LDEs) have become a critical issue in modern analog and mixed-signal circuit designs. The three major sources of LDEs, well proximity, length of oxide diffusion, and oxide-to-oxide spacing, significantly affect the threshold voltage and mobility of devices. In this paper, we propose the first work to consider the three major sources of LDEs during analog placement. We first transform the three LDE models into nonlinear analytical placement models. Then an LDE-aware analytical analog placement algorithm is presented to mitigate the influence of the LDEs while improving circuit performance. Experimental results show that our placement algorithm can effectively and efficiently reduce the LDE-induced variations and improve circuit performance.
Tracking targets using adaptive Kalman filtering (1990)

A simple algorithm for estimating the unknown process noise variance of an otherwise known linear plant, using a Kalman filter is suggested. The process noise variance estimator is essentially dead beat, using the difference between the expected prediction error variance, computed in the Kalman filter, and the measured prediction error variance. The estimate is used to adapt the Kalman filter. The use of the adaptive filter is demonstrated in a simulated example in which a wildly maneuvering target is tracked.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Use of the Chiral Pool — Practical Asymmetric Organocatalytic Strecker Reaction with Quinine. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of the Linkage between A-Polysaccharide and the Core in the A-Lipopolysaccharide of Porphyromonas gingivalis W50 (2015)

Porphyromonas gingivalis, a Gram-negative anaerobe, is considered to be an important etiologic agent in periodontal disease, and among the virulence factors produced by the organism are two lipopolysaccharides (LPSs), O-LPS and A-LPS. The structures of the O-PS and A-PS repeating units, the core oligosaccharide (OS), and the linkage of the O-PS repeating unit to the core OS in O-LPS have been elucidated by our group. It is important to establish whether the attachment site of the A-PS repeating unit to the core OS in A-LPS is similar to or differs from that of the O-PS repeating unit in O-LPS. As part of understanding the biosynthetic pathway of the two LPSs in P. gingivalis, PG0129 was identified as an α-mannosyltransferase that is involved in the synthesis of the outer core regions of both O-LPS and A-LPS.
On the Use of Intermediate Reboilers in the Rectifying Section and Condensers in the Stripping Section of a Distillation Column (1996)

Advantages of an intermediate reboiler in the stripping section of a distillation column and an intermediate condenser in the rectifying section are well-known. For highly nonideal mixtures the distillation process can be improved by placing an intermediate reboiler in the rectifying section of the column or an intermediate condenser in the stripping section, which is counterintuitive. In consequence the more expensive heating utility used in the bottom reboiler can be partially replaced with a less expensive heating medium (at a lower temperature) used in the intermediate reboiler. Similarly, a portion of the condensing duty from the top condenser can be replaced with the less expensive condensing duty (at a higher temperature) in the intermediate condenser. This placement of reboilers (condensers) can be used to reduce the total number of stages in the distillation column with a lower (higher) level of utility. Operating and capital costs of the distillation process with an intermediate heat exchanger can be lower than those for a classic column. A simple method providing valuable insights on the possible placement of intermediate heat exchangers along the column is proposed. It is based on calculations of the vapor flow along the height of a reversible, binary distillation column performing the equivalent separation task.
Effect of Supercritical Fluids on Field Emission from Carbon Nanotubes (2006)

This paper proposes a novel method to enhance the emission characteristics of carbon nanotubes (CNTs). It is extremely possible for CNTs to adsorb moisture and other contaminants during the fabrication processes, leading to the degraded field emission characteristics. In this work, CNT emitters are activated with commonly used heating process and supercritical carbon dioxide (SCCO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ) fluids technology for removing adsorbed residue moisture. Experimental results have demonstrated that the electrical stability and field emission enhancement of CNT emitters are effectively achieved by the SCCO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> fluids treatment compared to the heating process, due to the minimization of residuary moisture in CNTs.
Study of serum prostate specific antigen levels in patients with prostate lesions (2021)

In order to see a relationship between histopathology and PSA levels, group of 100 men were studied which included obtaining there Histopathological diagnosis and serum PSA levels before surgical intervention. We found that most common pathology encountered in prostate specimen is BPH. Most of disease of prostate occur in the age group of 61-70 years. With increasing PSA levels the possibility of malignancy increases. But Poorly differentiated tumor may not correlate with PSA level because the tumor cells may not produce PSA as they have lost differentiation.