gebhart/patrepeval huggingface dataset:
Synthesis of .alpha.-diketones by direct, low-temperature, in situ nucleophilic acylation of esters by acyllithium reagents (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .alpha.-diketones by direct, low-temperature, in situ nucleophilic acylation of esters by acyllithium reagentsDietmar Seyferth, Robert M. Weinstein, Richard C. Hui, Wei Liang Wang, and Colin M. ArcherCite this: J. Org. Chem. 1991, 56, 20, 5768–5773Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00020a014https://doi.org/10.1021/jo00020a014research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A randomized controlled trial of a therapeutic relational agent for reducing substance misuse during the COVID-19 pandemic (2021)

W-SUDs was associated with significant reductions in substance use occasions. Reduction in substance use occasions was associated with better outcomes, including improved mental health. W-SUDs satisfaction was high.
A comprehensive classification of solvent systems used for natural product purifications in countercurrent and centrifugal partition chromatography (2015)

Using both library paper copies and modern electronic copies, every known, published, English-language journal paper that employs either countercurrent or centrifugal partition chromatography solvent systems for natural product purifications has been studied and the solvent systems classified in a comprehensive database. Papers were studied from the earliest found examples containing natural product separations in 1984 until the end of 2014. In total, 2594 solvent systems have been classified, of which 272 are gradient systems. To observe any trends or patterns in the data, the natural product solutes were divided into 21 classes and the solvent systems into 7 different types. The complete database, sorted according to natural product class, is available for download to assist separation scientists in future liquid-liquid chromatography purifications.
A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. (1995)

Eukaryotic cells contain multiple Hsp70 proteins and DnaJ homologues. The partnership between a given Hsp70 and its interacting DnaJ could, in principle, be determined by their cellular colocalization or by specific protein-protein interactions. The yeast SCJ1 gene encodes one of several homologues of the bacterial chaperone DnaJ. We show that Scj1p is located in the lumen of the endoplasmic reticulum (ER), where it can function with Kar2p (the ER-lumenal BiP/Hsp70 of yeast). The region common to all DnaJ homologues (termed the J domain) from Scj1p can be swapped for a similar region in Sec63p, which is known to interact with Kar2p in the ER lumen, to form a functional transmembrane protein component of the secretory machinery. Thus, Kar2p can interact with two different DnaJ proteins. On the other hand, J domains from two other non-ER DnaJs, Sis1p and Mdj1p, do not function when swapped into Sec63p. However, only three amino acid changes in the Sis1p J domain render the Sec63 fusion protein fully functional in the ER lumen. These results indicate that the choice of an Hsp70 partner by a given DnaJ homologue is specified by the J domain.
Working in the Fantasy Factory (2000)

Using ethnographic data, this article argues that interactions between strippers and their customers are vehicles for the conveyance of attention and the enactment of masculine power in addition to being locations of erotic entertainment. Rejecting the anti-sex-work feminist argument that erotic entertainment serves men by objectifying women, this article argues instead that interactions in strip clubs rely on dancers as interactive subjects rather than as sex objects. Using Goffman's notion of “impression management” and Hochschild's notion of “emotional labor,” this article presents an analysis of strip club encounters that fits into a feminist-interactionist framework.
Pseudospectral Fourier reconstruction with IPRM (2009)

We generalize the Inverse Polynomial Reconstruction Method (IPRM) for mitigation of the Gibbs phenomenon by reconstructing a function as an algebraic polynomial of degree $n-1$ from the function's $m$ lowest Fourier coefficients ($m ge n$). We compute approximate Legendre coefficients of the function by solving a linear least squares problem, and we show that the condition number of the problem does not exceed $sqrtfrac{m}{{m-alpha_0 n^2}}$, where $alpha_0 = frac{4sqrt{2}}{pi^2} = 0.573 ldots$. Consequently, whenever mbox{$m ge n^2$,} the convergence rate of the modified IPRM for an analytic function is root exponential on the whole interval of definition. Stability and accuracy of the proposed algorithm are validated with numerical experiments.
Comparison between co-crystallisation properties of POP and OPP : a tool to understand industrial processes (2004)

peer reviewed
Preparation and catalytic properties of a bimetallic SnPt complex in the supercages of NaY zeolite by use of surface organometallic chemistry (2007)

Abstract The grafting reaction of SnMe 4 on the surface of Pt/NaY zeolite was investigated in a 1.6 × 10 4 Pa hydrogen atmosphere. The chemical compositions, structure and properties of the resulting solid were characterized by in situ FTIR, ICP, XRD, XPS, temperature programmed decomposition and nitrogen adsorption. The results show that Pt atoms of Pt/NaY zeolite react with tetramethyltin to form a bimetallic Me 3 SnPt surface species in the presence of hydrogen at 353 K. The reaction does not destroy the zeolite framework, while its surface properties are changed. The BET surface area and the pore volume of the zeolite decrease significantly. The CO chemisorption results and the XPS results show that the electronic properties of the modified Pt atoms on the surface of NaY zeolite are altered remarkably by the inductive effect of electron between Pt and methyl groups. The grafted product has excellent selective hydrogenation of furfural to furfuryl alcohol. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Co-Catalytic Effects in Phase-Transfer Catalyzed Reactions (1987)

The phase-transfer catalyzed alkylation reaction of diethyl malonate with butyl bromide using solid potassium carbonate as base could not be accelerated above a limiting reaction rate by increasing the concentration of the onium salt catalyst. The rate limit could be exceeded by using crown ether in addition to an onium salt. Polyethylene glycols exhibit a similar effect. These results were used to improve the yields in a series of related alkylation reactions.
Selective in vivo mobilization with granulocyte macrophage colony-stimulating factor (GM-CSF)/granulocyte-CSF as compared to G-CSF alone of dendritic cell progenitors from peripheral blood progenitor cells in patients with advanced breast cancer undergoing autologous transplantation. (1999)

Dendritic cells (DCs) are potent antigen-presenting cells that are essential for the initiation of T cell-mediated immunity. DCs develop from myeloid progenitor populations under the influence of granulocyte macrophage colony-stimulating factor (GM-CSF) and pass through an intermediate stage of maturation that is characterized by CD14 expression. Interest has focused on generating human-derived DCs for antigen-specific tumor vaccines to be used as adjuvant immunotherapy in minimal disease settings, such as after autologous transplantation. In the present study, mobilized peripheral blood progenitor cells (PBPCs) were obtained from 18 patients with locally advanced or metastatic breast cancer preparing to undergo autologous stem cell transplantation. PBPCs mobilized in 10 patients with GM-CSF for 1 week, followed by the combination of GM-CSF and G-CSF, were compared with those obtained from patients receiving G-CSF alone with respect to the presence of DC progenitors and the capacity to generate functionally active mature DCs. PBPCs mobilized with GM-CSF/G-CSF were markedly enriched for CD14+ DC progenitor cells as compared with those mobilized with G-CSF alone. Consistent with an immature progenitor population, the CD14+ cells express Ki-67 antigen but not nonspecific esterase. CD14+ cells purified by fluorescence-activated cell sorting from PBPCs mobilized with either regimen and cultured for 1 week in GM-CSF and interleukin-4 generated nearly pure populations of cells with characteristic DC phenotype and function. The addition of GM-CSF to the mobilization regimen resulted in greater yields of functionally active DCs for potential use in posttransplant immunotherapy.
[Percutaneous "sandwich" endopyeloplasty technique: a new endourological measure for ureteropelvic junction obstruction]. (2015)

Percutaneous "sandwich" endopyeloplasty shows good results for UPJO of selected patients with simple operation, minimal invasiveness, quick recovery and few severe complications.
Pillars of assembled pyridyl bis-urea macrocycles: a robust synthon to organize diiodotetrafluorobenzenes (2016)

Columnar assembled pyridyl bis-urea macrocycles 1 provide a strong 1D supramolecular synthon to construct hierarchical assemblies. These 1D pillars contain ditopic symmetrical acceptors in the form of basic oxygen lone pairs. Herein, we probe this synthon with a series of activated halogen bond donors, the regio-isomers of diiodotetrafluorobenzenes, which vary the relative orientation of the halogen bond formers. Irrespective of the initial stoichiometry, each donor only formed one type of co-crystal with 1. In each case, similar strong pillars of assembled 1 were observed that organize the donors through the CO⋯I interaction, which were significantly shorter than the sum of the van der Waals radii of the atoms involved and among the shortest reported for neutral organic molecules. X-ray photoelectron spectroscopy characteristic core level shifts strongly indicated the formation of halogen bonding interactions. These studies suggest that this synthon can utilize both hydrogen and halogen bonding orthogonally to build complex structures.
On the rate of convergence of the bagged nearest neighbor estimate (2010)

Bagging is a simple way to combine estimates in order to improve their performance. This method, suggested by Breiman in 1996, proceeds by resampling from the original data set, constructing a predictor from each subsample, and decide by combining. By bagging an n-sample, the crude nearest neighbor regression estimate is turned into a consistent weighted nearest neighbor regression estimate, which is amenable to statistical analysis. Letting the resampling size kn grows appropriately with n, it is shown that this estimate may achieve optimal rate of convergence, independently from the fact that resampling is done with or without replacement. Since the estimate with the optimal rate of convergence depends on the unknown distribution of the observations, adaptation results by data-splitting are presented.
HTM2: Spatial Toolkit for the Virtual Observatory (2003)

The hierarchical tringular mesh (HTM) is a discrete foundation for describing location, size and shape on the celestial sphere. Indices derived from HTM descriptors are used in a relational database for managing spatial information. Some of the new features available in the current implementation support operations such as the ability to perform searches based on arbitrary polygons, convex hulls of polygons or any region bounded by great or small circles. These functions are reached through a language that is implemented as an extension to MSQL Server 2000 relational database engine. The heart of the HTM tools can also be used through various interfaces in several langugages, like C++, C# and Java. An extensive XML specification for describing spatial structures to support spatial queries is also under development.
Light field mapping: efficient representation of surface light fields (2002)

A light field parameterized on the surface offers a natural and intuitive description of the view-dependent appearance of scenes with complex reflectance properties. To enable the use of surface light fields in real-time rendering we develop a compact representation suitable for an accelerated graphics pipeline. We propose to approximate the light field data by partitioning it over elementary surface primitives and factorizing each part into a small set of lower-dimensional functions. We show that our representation can be further compressed using standard image compression techniques leading to extremely compact data sets that are up to four orders of magnitude smaller than the input data. Finally, we develop an image-based rendering method, light field mapping, that can visualize surface light fields directly from this compact representation at interactive frame rates on a personal computer. We also implement a new method of approximating the light field data that produces positive only factors allowing for faster rendering using simpler graphics hardware than earlier methods. We demonstrate the results for a variety of non-trivial synthetic scenes and physical objects scanned through 3D photography.
Scattering suppression in plasmonic optics using a simple two-layer dielectric structure (2011)

We demonstrate that a planar structure consisting of two isotropic dielectric layers can be used to minimize parasitic scattering in plasmonic elements. It is shown using rigorous electromagnetic simulations that the utilization of the proposed structure allows reducing the scattering losses by an order-of-magnitude (1%–2%). The proposed approach can be used for the design of various plasmonic elements such as lenses, reflectors, and plasmonic crystals.
Polarization-extinction-based detection of DNA hybridization in situusing a nanoparticle wire-grid polarizer (2012)

Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.
Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis (2014)

Our data suggest that distinct molecular pathways may be involved in ASD with known but different genetic causes and that blood gene expression profiles of Fmr1-KO and Tsc2+/- mice mirror some, but not all, of the perturbed molecular pathways in the brain.
Self-Adapting dc Converter for Solar Spacecraft Power Supply Selbstanpassender Gleichstromwandler für die Energieversorgung eines Sonnensatelliten (1968)

The voltage-current characteristic of solar cells that provide power for a spacecraft can vary over a wide range. For maximum power transfer from the solar cells to the battery system a power converter has to be designed that adjusts its input impedance to a value equal to the output impedance determined by the operating power characteristic of the solar cells. This paper discusses a circuit and calculations for a design to match this condition. The proposed power converter is simple, lightweight, and reliable and will be used in the Sunblazer satellite.
PD49-11 METABOLIC DYSFUNCTION AND HYPOGONADISM IN A COHORT OF YOUNG, HEALTHY MEN (2018)

and neuronal nitric oxide synthase (nNOS), tyrosine hydroxylase (TH) and TUNEL assay expression were measured 72h. Gene expression of nNOS, TH, beta-tubulin, Schwann cells (glial fibrillary acidic protein; GFAP), markers of nerve injury (activating transcription factor 3; ATF3) and regeneration (growth associated protein 43, GAP43) was also measured in irradiated MPGs (n6/grp).
Transcript Initiation and 5′-End Modifications Are Separable Events during Vesicular Stomatitis Virus Transcription (1999)

In this report we describe a novel, bipartite vesicular stomatitis virus (VSV) replication system which was used to study the effect of mutations in the transcription start sequence on transcript initiation and 5'-mRNA modifications. The bipartite replication system consisted of two genomic RNAs, one of which (VSVDeltaG) was a recombinant VSV genome with the G gene deleted and the other (GFC) contained the G gene and two non-VSV reporter genes (green fluorescent protein [GFP] and chloramphenicol acetyltransferase [CAT]). Coinfection of cells with these two components resulted in high-level virus production and gave titers similar to that from wild-type-VSV-infected cells. Mutations were introduced within the first 3 nucleotides of the transcription start sequence of the third gene (CAT) of GFC. The effects of these changes on the synthesis and accumulation of CAT transcripts during in vivo transcription (e.g., in infected cells), and during in vitro transcription were determined. As we had reported previously (E. A. Stillman and M. A. Whitt, J. Virol. 71:2127-2137, 1997), changing the first and third nucleotides (NT-1 and NT-3) reduced CAT transcript levels in vivo to near undetectable levels. Similarly, changing NT-2 to a purine also resulted in the detection of very small amounts of CAT mRNA from infected cells. In contrast to the results in vivo, the NT-1C mutant and all of the second-position mutants produced near-wild-type amounts of CAT mRNA in the in vitro system, indicating that the mutations did not prevent transcript initiation per se but, rather, generated transcripts that were unstable in vivo. Oligo (dT) selection and Northern blot analysis revealed that the transcripts produced from these mutants did not contain a poly(A)(+) tail and were truncated, ranging in size from 40 to 200 nucleotides. Immunoprecipitation analysis of cDNA-RNA hybrids with an antibody that recognizes trimethylguanosine revealed that the truncated mutant transcripts were not properly modified at the 5' end, indicating the transcripts either were not capped or were not methylated. This is the first demonstration that transcript initiation and capping/methylation are separable events during VSV transcription. A model is proposed in which polymerase processivity is linked to proper 5'-end modification. The model suggests that a proofreading mechanism exists for VSV and possibly other nonsegmented minus-strand RNA viruses, whereby if some transcripts do not become capped during transcription in a normal infection, a signal is transduced such that the polymerase undergoes abortive elongation and the defective transcript is terminated prematurely and subsequently degraded.
Airfield Repairs in Austere Locations Using Pelletized Asphalt Technology (2009)

The use of pelletized asphalt technology to produce airfield-quality hot-mix asphalt (HMA) is evaluated in this study. The pelletization process produces HMA mix components (asphalt cement, fine aggregate, fiber, and polymer) as a pre-manufactured product that can be shipped at ambient temperature to austere locations. There, it can be introduced to locally-produced, heated coarse aggregate in a continuous or batch plant. Two HMA mix types known to provide high shear and rutting resistance were designed and subjected to laboratory tests; one was the stone mastic asphalt (SMA) mix and the other was a dense-graded airfield (DGA) HMA mix. Laboratory tests using the asphalt pavement analyzer indicated that DGA mixes had better rutting resistance compared to the SMA mixes. Thus, the test sections (one pelletized mix and one conventional HMA mix) at Silver Flag Test Area were built using the DGA mix gradation. The conventional HMA mix served as the experimental control. The test sections were trafficked with 1,500 passes of the F-15E load cart to evaluate the rutting performance of the pelletized asphalt HMA. The pelletized asphalt HMA section showed no rutting. The conventional asphalt test section, on the other hand, exhibited as much as 22 mm of rutting. The study concluded that it is feasible to produce airfield-quality HMA with pelletized asphalt using conventional HMA plants. Conventional construction equipment was adequate for placing a durable and rut-resistant pelletized HMA pavement. This paper presents results of laboratory and field tests and provides status of field implementation of the technology.
Ash : a novel (2001)

Caitlin Ober is back in Japan, teaching English in Kyushu. Some 15 years ago, as a little girl, Caitlin lived in Kyoto, but a tragic accident drove her and her family back to America. Now guilt obscures her path, just as ashfall from a nearby volcano covers Kagoshima in dust. In a garden Caitlin meets a teenage half-Japanese girl, Naomi, who may be someone Caitlin can save this time around. Together the two travel to Kyoto during O-Bon, the festival when the dead return. Amid bonfires, temple grounds, and ghostly memories, Caitlin bravely embraces her future. Ash is a bittersweet novel of redemptive beauty, of startling images and alluring details.Holly Thompson lives in Kamakura and writes frequently about Japan. This is her first novel.
Textural Pattern Classification of Microscopic Images for Malaria Screening (2012)

RE comprises all techniques and devices that deal with improving, assisting, or mimicking the various day-to-day functions carried out by our bodies, thereby improving the overall quality of life. Various topics include, but are not limited to, assistive devices and other aids for those with disabilities, sensory augmentation and substitution systems, functional electrical stimulation (FES; for motor control and sensory-neural prostheses), orthotics and prosthetics, myoelectric devices and techniques, transducers (including electrodes), signal processing, hardware, software, robotics, systems approaches, technology assessment, postural stability, wheelchair seating systems, gait analysis, biomechanics, biomaterials, control systems (both biological and external), ergonomics, human performance, and functional assessment.
Surface‐Enhanced Raman Spectroscopy for Glucose Sensing (2009)

This chapter contains sections titled: Background Experimental Procedures Results Conclusions Acknowledgments References