gebhart/patrepeval huggingface dataset:
Figure S4 from Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel (2023)

&lt;p&gt;Correlation of baseline IL6 levels(pg/mL) with IL6 levels collected on day of axi-cel infusion (A) and peak levels (B)&lt;/p&gt;
Metadata integration architecture in enterprise data warehouse system (2010)

Due to the increasing complexity of data warehouses, a centralized and declarative management of metadata is essential for data warehouse administration, maintenance and usage. Metadata integration architecture is technical system architecture to achieve metadata management strategy. In this paper, under the background of China Pacific Insurance Company (CPIC) building enterprise data warehouse(EDW) project, we research on metadata integration architecture. First, three kinds of metadata integration architecture were introduced, include: centralized architecture, federal architecture, distributed architecture. Next, applying the federal architecture, we proposed CPIC EDW metadata integration planning. Then again, using CouchDB as the backend, we have developed a metadata management system based on document. As an important enhancements, document based metadata stored in CouchDB in company with metadata stored in MetaStage, constitute the overall CPIC EDW global metadata storage. Finally, we concluded that: ①at this stage, metadata management system in enterprise data warehouse should adopt a federal integration architecture; ② Document based metadata stored in CouchDB can be an important supplementary of the global metadata repository.
Early clinical and sociodemographic experience with patients hospitalized with COVID-19 at a large American healthcare system (2020)

Patients hospitalized with COVID-19 are frequently of vulnerable socioeconomic status and often require intensive care. Patients who survive COVID-19 hospitalization have substantial need for post-acute services.
Supercritical Fluid Extraction of Eucalyptus globulus Bark—A Promising Approach for Triterpenoid Production (2012)

Eucalyptus bark contains significant amounts of triterpenoids with demonstrated bioactivity, namely triterpenic acids and their acetyl derivatives (ursolic, betulinic, oleanolic, betulonic, 3-acetylursolic, and 3-acetyloleanolic acids). In this work, the supercritical fluid extraction (SFE) of Eucalyptus globulus deciduous bark was carried out with pure and modified carbon dioxide to recover this fraction, and the results were compared with those obtained by Soxhlet extraction with dichloromethane. The effects of pressure (100-200 bar), co-solvent (ethanol) content (0, 5 and 8% wt), and multistep operation were studied in order to evaluate the applicability of SFE for their selective and efficient production. The individual extraction curves of the main families of compounds were measured, and the extracts analyzed by GC-MS. Results pointed out the influence of pressure and the important role played by the co-solvent. Ethanol can be used with advantage, since its effect is more important than increasing pressure by several tens of bar. At 160 bar and 40 °C, the introduction of 8% (wt) of ethanol greatly improves the yield of triterpenoids more than threefold.
2,6-Bis(9-ethyl-9H-carbazolylmethylene)cyclohexanone (2009)

The title compound, 2,6-bis(ethyl-9-ethyl-9H-carbazolylmethylene)cyclohexanone has been synthesized by condensation of 9-ethylcarbazole-3-aldehyde and cyclohexanone in ethanol in the presence of pyridine. The structure of this new compound was confirmed by elemental analysis, IR, 1H NMR, 13C NMR and EI-MS spectral analysis.
Determination of the Excitatory Potencies of Fluoroquinolones in the Central Nervous System by an In Vitro Model (1998)

Fluoroquinolones have been reported to induce central nervous system side effects, including seizures and psychiatric events. Although relatively rare in patients up to now, the proconvulsant activity depends on the chemical structure and might be a critical endpoint of some new representatives of this valuable class of antimicrobials. The electrophysiological determination of field potentials in the CA1 region of the rat hippocampus slice allowed an assessment of the excitatory potential of fluoroquinolones and might be predictive for their neurotoxic potency in vivo. An optimization of this method and its extension to other fluoroquinolones resulted in a defined rank order. Well-known already-marketed quinolones as well as some fluoroquinolones under evaluation and development were used. The dose range tested was between 0.5 and 4 mumol/liter, which was comparable to the therapeutic concentration in the brain. All tested compounds increased the population spike amplitude in a concentration-dependent manner, and the resulting excitatory potency was highly dependent on the chemical structure, with compounds ranging from least to most excitatory as follows: ofloxacin, ciprofloxacin, nalidixic acid, moxifloxacin, BAY x 8843, [corrected] fleroxacin, lomefloxacin, enoxacin, clinafloxacin (much more excitatory than enoxacin), tosufloxacin, trovafloxacin, BAY 15-7828, and BAY x 9181 (much more excitatory than BAY 15-7828). The proposed hippocampus slice model not only is suitable for giving valuable alerts as to convulsive potential during candidate selection but also enables mechanistic investigations. These investigations pointed to the N-methyl-D-aspartate receptor as the probable target of the fluoroquinolone effects.
Supplementary Figure 4 from Oncolytic Virus and Anti–4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer (2023)

&lt;p&gt;PDF file - 104K&lt;/p&gt;
Supplementary Figure 3 from <i>TMPRSS2:ERG</i> Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer (2023)

Supplementary Figure 3 from &lt;i&gt;TMPRSS2:ERG&lt;/i&gt; Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer
Quantitation of cytidine‐5′‐monophospho‐N‐acetylneuraminic acid in human leukocytes using LC–MS/MS: method development and validation (2019)

The biosynthesis of sialic acid (Neu5Ac) leads to the intracellular production of cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), the active sialic acid donor to nascent glycans (glycoproteins and glycolipids) in the Golgi. UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase myopathy is a rare autosomal recessive muscular disease characterized by progressive muscle weakness and atrophy. To quantify the intracellular levels of CMP-Neu5Ac as well as N-acetylmannosamine (ManNAc) and Neu5Ac in human leukocytes, we developed and validated robust liquid chromatography-tandem mass spectrometry methods. A fit-for-purpose approach was implemented for method validation. Hydrophilic interaction chromatography was used to retain three hydrophilic analytes. The human leukocyte pellets were lysed and extracted in a methanol-water mixture and the leukocyte extract was used for LC-MS/MS analysis. The lower limits of quantitation for ManNAc, Neu5Ac and CMP-Neu5Ac were 25.0, 25.0 and 10.0 ng/ml, respectively. These validated methods were applied to a clinical study.
Using optical methods to reveal structural features in porous nanocomposite films of the tin dioxide-silicon dioxide system (2011)

Nanocomposite films of the tin dioxide-silicon dioxide system have been obtained by the sol-gel method using various solvents (ethanol, butanol) and their optical properties have been studied in the 300–700 nm wavelength range. The obtained data were used to calculate the Uhrbach energy parameters, slope parameters, and band-gap energies of the films. The results are interpreted within the framework of the model of fractal nanocluster growth and evolution during the sol-gel process. The employed optical method can be effectively used to study the optical properties of nanocomposites for optimizing their production technology.
Radio interferometric determination of source positions utilizing deep space network antennas - 1971 to 1980 (1984)

Approximately 2400 observations of extragalactic radio sources were made between August 1971 and February 1980 during 48 separate sessions. These consisted of 259 delay rate observations at 2.3 GHz (S-band), 796 delay and delay rate observations at either S-band of 8.3 GHz (X-band) and 1325 delay and delay rate observations recorded simultaneously at both S- and X-band. A single multiparameter fit has been applied to the observed values of delay and delay rate to extract astrometric and geophysical parameters from this decade-long sequence. The fit produced estimates of 784 parameters, including station locations, radio source positions, polar motion, Universal Time, the precession constant, and solid earth tides. The a priori model included gravitational bending, the 1980 IAU nutation series, the 1976 IAU expressions for Greenwich mean sidereal time and precession, BIH estimates of Universal Time and polar motion, and monthly mean values for zenith troposphere delay. The rms residuals were 0.52 nsec for delay and 0.30 psec/sec for delay rate. Intercontinental baseline lengths were determined with formal uncertainties of 5 to 10 cm. Universal Time and polar motion were measured at 49 epochs, with formal uncertainties (for the more recent data) of 0.5 msec for UT1 and 6 and 2 mas, respectively, for the X and Y components of polar motion. Previously announced in STAR as N83-28038
Alberico Gentili (1552–1608) (2017)

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Molybdenum sulfide/graphene-carbon nanotube nanocomposite material for electrocatalytic applications in hydrogen evolution reactions (2016)

We report a three-dimensional hierarchical ternary hybrid composite of molybdenum disulfide (MoS2), reduced graphene oxide (GO), and carbon nanotubes (CNTs) prepared by a two-step process. Firstly, reduced GO–CNT composites with three-dimensional microstructuresare synthesized by hydrothermal treatment of an aqueous dispersion of GO and CNTs to form a composite structure via π–π interactions. Then, MoS2 nanoparticles are hydrothermally grown on the surfaces of the GO–CNT composite. This ternary composite shows superior electrocatalytic activity and stability in the hydrogen evolution reaction, with a low onset potential of only 35 mV, a Tafel slope of ~38 mV·decade−1, and an apparent exchange current density of 74.25 mA·cm−2. The superior hydrogen evolution activity stemmed from the synergistic effect of MoS2 with its electrocatalytically active edge-sites and excellent electrical coupling to the underlying graphene and CNT network.
DEPROTECTION OF AN ACETAL BENZYLIDENE WITH A PHENOMENON OF EPIMERIZATION OF THE ANOMERIC CENTER OF A PYRAZOLO-PYRANOSOIDE DERIVATIVE (2019)

In order to study the reactivity of the pyranose part of the pyrazolo-pyranoside platform, we opted for an opening of the benzylidene acetal by an acid hydrolysis reaction. Unexpected platform reactivity at the anomeric carbon level was observed, resulting in a minority compound whose benzylidene is unchanged and a 4,6-diol whose ethoxy groups at the anomeric position are replaced by ethoxy groups.
Ultrahigh density vertical magnetoresistive random access memory (invited) (2000)

In this paper, we present the vertical magnetoresistive random access memory (VMRAM) design based on micromagnetic simulation analysis. The design utilizes the vertical giant magnetoresistive effect of the magnetic multilayer. By making the memory element into a ring-shaped magnetic multilayer stack with orthogonal paired word lines, magnetic switching of the memory device becomes very robust. The design also adopts the readback scheme in pseudo spin valve MRAM so that only one transistor is needed for each bit line which can connect hundreds of memory elements, yielding a very high area density. It is estimated that the ultimate area density for the VMRAM is 400 Gbits/in.2. It is suggested that this memory design has the potential to not only replace the present semiconductor memory devices, such as FLASH, but also the potential to replace DRAM, SRAM, and even disk drives.
A3 Adenosine Receptor Signaling Contributes to Airway Mucin Secretion after Allergen Challenge (2006)

Mucin hypersecretion is a prominent feature of obstructive airway diseases such as asthma. Clara cells conditionally produce mucin in response to inflammatory signals in a process termed mucous metaplasia. This can be followed by mucin secretion stimulated by various signaling molecules. The cellular and molecular mechanisms that regulate mucin production and secretion are not well understood. Adenosine is a signaling nucleoside that has been implicated in airway diseases in which mucus obstruction is prominent. Furthermore, the A(3) adenosine receptor (A(3)AR) is upregulated in mucin-producing goblet cells of the airway, thereby implicating it in processes involved in mucous cell biology. Here we use genetic approaches to investigate the contribution of A(3)AR signaling to mucus production and secretion in a mouse model of allergen-induced pulmonary disease. We found that the degree of mucin production in response to allergen is similar in wild-type and A(3)AR-deficient mice, and that overexpression of this receptor in Clara cells neither induces mucin production itself, nor enhances mucin production in response to allergen challenge. Collectively, these experiments demonstrate that the A(3)AR is neither necessary nor sufficient for mucous cell metaplasia. In contrast to the lack of effect on mucin production, agonist-induced mucin secretion was increased in goblet cells overexpressing the A(3)AR, and was absent in A(3)AR-deficient mice. Thus, the A(3)AR contributes to mucin secretion in allergen-induced metaplasia. Signaling through this receptor may contribute to mucus airway obstruction seen in pulmonary disorders in which adenosine levels are elevated.
Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex (1995)

The putative anti-addiction alkaloid ibogaine and its principal metabolite 12-hydroxyibogamine appear to act at the (+)-5 methyl-10,11,dihydro-5H- dibenzo[a,d]cycloheten-5-10-imine maleate (MK-801) binding site in the N-methyl-D-aspartate (NMDA)-receptor cation channel. This conclusion is based on findings that both compounds competitively displaced specific [3H]MK-801 binding to membranes from postmortem human caudate and cerebellum and from frog spinal cord. Ibogaine was 4-6-fold more potent than its metabolite and both compounds were less potent (50-1000-fold) than MK-801 binding to the NMDA receptor. In addition, ibogaine (100 microM) and 12-hydroxyibogamine (1 mM) blocked (85-90% of control) the ability of NMDA (100 microM, 5 s) to depolarize frog motoneurons in the isolated frog spinal cord. The prevention of NMDA-depolarizations in frog motoneurons showed use-dependency and was very similar to the block produced by MK-801. In view of the abilities of MK-801 to affect the responses to addictive substances in pre-clinical investigations, our results are compatible with the idea that the ability of ibogaine and 12-hydroxyibogamine to interrupt drug-seeking behavior may, in part, result from their actions at the MK-801 binding site.
Nanopore Event-Transduction Signal Stabilization for Wide pH Range under Extreme Chaotrope Conditions (2016)

Operation of an α-hemolysin nanopore transduction detector is found to be surprisingly robust over a critical range of pH (6-9), including physiological pH = 7.4 and polymerase chain reaction (PCR) pH = 8.4, and extreme chaotrope concentration, including 5 M urea. The engineered transducer molecule that is captured in the standard α-hemolysin nanopore detector, to transform it into a transduction detector, appears to play a central role in this stabilization process by stabilizing the channel against gating during its capture. This enables the nanopore transduction detector to operate as a single molecule "nanoscope" in a wide range of conditions, where tracking on molecular state is possible in a variety of different environmental conditions. In the case of streptavidin biosensing, results are shown for detector operation when in the presence of extreme (5 M) urea concentration. Complications involving degenerate states are encountered at higher chaotrope concentrations, but since the degeneracy is only of order two, this is easily absorbed into the classification task as in prior work. This allows useful detector operation over a wide range of conditions relevant to biochemistry, biomedical engineering, and biotechnology.
A CCR2-V64I polymorphism affects stability of CCR2A isoform (2004)

These results suggest that CCR2A binds to CCR5 in the cytoplasm and down-modulates its surface expression. We propose that the increased ability of CCR2A-64I to down-modulate CCR5 expression might be a possible cause of a delay in HIV-1 disease progression in patients with this allele.
Studies of a controlled-release microcapsule formulation of an LH-RH agonist (D-Trp-6-LH-RH) in the rhesus monkey menstrual cycle. (1985)

It has been shown that continuous administration of LH-RH agonists inhibits ovulation in many species, including human and nonhuman primates. However, the need of daily injections or intranasal application of the LH-RH agonists makes this contraceptive approach impractical. In addition, due to the repeated daily administration of the LH-RH analogues and their bioavailability, serum levels of gonadotropins and estradiol present wide variations and are often associated with irregular bleeding and/or endometrial hyperplasia. This experiment was designed to study the effects on ovulation and the hormonal profile during the rhesus monkey menstrual cycle of a system that continuously delivers a potent agonist of LH-RH (D-Trp-6-LH-RH encapsulated in poly [DL-lactide-co-glycolide]). Subjects were divided into two groups: On day 1 of the cycle, monkeys received a single subcutaneous injection of microcapsules containing D-Trp-6-LH-RH at a release rate of 13.6 micrograms/day (Group 1) or placebo microcapsules (Group 2). Ovulation dates were significantly delayed in animals from Group 1 (50 +/- 3 days) as compared to those in group 2 (20 +/- 2 days). Luteal phases following ovulation were normal in animals of both groups, as determined by length and serum progesterone levels. No significant differences on baseline levels of FSH and LH were observed between the two groups of animals. Post-treatment cycles were ovulatory and presented normal luteal phases and hormone concentrations as compared to the non-treated animals of our colony. The present data show for the first time that a controlled-release microcapsule formulation that delivers an agonist of LH-RH can effectively suppress ovulation when injected in a single dose in non-human primates.
Aerobic and resistance exercise improve patient-reported sleep quality and is associated with cardiometabolic biomarkers in Hispanic and non-Hispanic breast cancer survivors who are overweight or obese: results from a secondary analysis (2021)

NCT01140282.
A traveling-wave THz photomixer based on angle-tuned phase matching (1999)

A traveling-wave THz photomixer based on a free-space optical-THz phase-matching scheme is proposed. A dc-biased coplanar strip line fabricated on low-temperature-grown GaAs serves as the active area of the device, and is illuminated by two noncollinear laser beams which generate interference fringes that are accompanied by THz waves. The device with the laser-power-handling capability over 300 mW and a 3-dB bandwidth of 1.8 THz was experimentally demonstrated. The results show that traveling-wave photomixers have the potential to surpass small-area designs.
[Medication compliance and diet compliance in 309 oral lichen planus patients]. (2016)

According to the limited data in the study, Benex extraction System is a convenient, atraumatic and predictable technique during flapless immediate implant placement in anterior teeth.
Mechanisms of Transcellular C1-Transport in Mammalian Renal Proximal Tubules (1989)

In mammalian renal proximal tubule, a significant fraction of Cl- reabsorption passes through the cell by electroneutral mechanisms. At the apical membrane, Cl- is taken up into the cell by a Cl--base exchange, and it appears to exit the basolateral membrane through K+-Cl- cotransport and Na+-HCO3--Cl- exchange.
Optical vortex arrays from smectic liquid crystals (2014)

We demonstrate large-area, closely-packed optical vortex arrays using self-assembled defects in smectic liquid crystals. Self-assembled smectic liquid crystals in a three-dimensional torus structure are called focal conic domains. Each FCD, having a micro-scale feature size, produces an optical vortex with consistent topological charge of 2. The spiral profile in the interferometry confirms the formation of an optical vortex, which is predicted by Jones matrix calculations.
Progress in the studies on epigenetic regulation of obesity (2016)

Obesity is considered to be a complex disease which is jointly caused by genetic and environmental factors. And it has become one of the most serious public health problems of modern human society. In the occurrence and development of obesity, epigenetic regulation plays an extremely important role. The main way of epigenetic regulation include: the methylation of DNA, non-coding RNA, and histone modifications. Recently, the study of the histone modification became especially thorough and precise. In this paper, we briefly review the status and progress of obesity-related research in the epigenetic areas.


Key words: 
Obesity; DNA methylation; MicroRNA; Histone modification; Adipogenic
Significance of Ectodomain Cysteine Boxes 2 and 3 for the Activation Mechanism of the Thyroid-stimulating (2006)

Recently, we identified constitutively activating mutations atpositions Asp-403, Glu-404, and Asn-406 in the third extracel-lular cysteine box (C-b3) of the thyroid-stimulating hormonereceptor.Wehypothesizedthatthisregioncouldactasamolec-ularinterfacebetweentheextracellularandserpentinedomain.In this study we present a model for properties of potentialinteraction partners for this region. Moreover, we show thatPro-400andPro-407adjacenttothisepitopearealsoimportantfor stabilizing the partially active, basal conformation of thewild-type (WT) thyroid-stimulating hormone receptor. Fur-thermore, the mutation K291A in the second extracellular cys-teinebox(C-b2)wasidentifiedasanewconstitutivelyactivatingmutationthatreleasesthebasalconformationoftheWTrecep-tor like the known tryptic cleavage in its close vicinity. Takentogether, we provide an activation scenario at the C-b2/C-b3unit. Three anchor fragments (anchors I-III) most likely con-strain the basal conformation. The three anchor fragments aretightlypacked.AdisulfidebridgeholdstheC-b2/C-b3portionsin close positions. Independent of the type of conformationalinterference such as side chain modifications, tryptic cleavage,or hormone stimulation that act on the constrained C-b2/C-b3WTconformation,itwillalwaysreleaseoneoftheanchorfrag-ments. Subsequently, this results in a conformational displace-mentoftheC-b2/C-b3portionsrelativetoeachother,inducingreceptor activation.