gebhart/patrepeval huggingface dataset:
Thioaldehyde Diels-Alder reactions (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThioaldehyde Diels-Alder reactionsE. Vedejs, T. H. Eberlein, D. J. Mazur, C. K. McClure, D. A. Perry, R. Ruggeri, E. Schwartz, J. S. Stults, D. L. Varie, and Cite this: J. Org. Chem. 1986, 51, 9, 1556–1562Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00359a034https://doi.org/10.1021/jo00359a034research-articleACS PublicationsRequest reuse permissionsArticle Views1829Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Self‐Improved Water‐Oxidation Catalyst: Is One Site Really Enough? (2013)

The homogeneous catalysis of water oxidation by transition-metal complexes has experienced spectacular development over the last five years. Practical energy-conversion schemes, however, require robust catalysts with large turnover frequencies. Herein we introduce a new oxidatively rugged and powerful dinuclear water-oxidation catalyst that is generated by self-assembly from a mononuclear catalyst during the catalytic process. Our kinetic and DFT computational analysis shows that two interconnected catalytic cycles coexist while the mononuclear system is slowly and irreversibly converted into the more stable dinuclear system: an extremely robust water-oxidation catalyst that does not decompose over extended periods of time.
Configuring sessions in programmable networks (2002)

The provision of advanced computational services within networks is rapidly becoming both feasible and economical. We present a general approach to the problem of configuring application sessions that require intermediate processing by showing how the session configuration problem can be transformed to a conventional shortest path problem for unicast sessions or to a conventional Steiner tree problem for multicast sessions. We show, through a series of examples, that the method can be applied to a wide variety of different situations.
Explainable Deep Learning for Non-Invasive Detection of Pulmonary Artery Hypertension from Heart Sounds (2022)

Late diagnoses of patients affected by pulmonary artery hypertension (PH) have a poor outcome.This observation has led to a call for earlier, non-invasive PH detection.Cardiac auscultation offers a non-invasive and cost-effective alternative to both right heart catheterization and doppler analysis in analysis of PH.We propose to detect PH via analysis of digital heart sound recordings with over-parameterized deep neural networks.In contrast with previous approaches in the literature, we assess the impact of a pre-processing step aiming to separate S2 sound into the aortic (A2) and pulmonary (P2) components.We obtain an area under the ROC curve of .95,improving over our adaptation of a state-of-the-art Gaussian mixture model PH detector by +.17.Post-hoc explanations and analysis show that the availability of separated A2 and P2 components contributes significantly to prediction.Analysis of stethoscope heart sound recordings with deep networks is an effective, low-cost and non-invasive solution for the detection of pulmonary hypertension.
Effects of Nd:YAG laser for the controlled and localized treatment of early gastrointestinal tumors: Preliminary in vivo study (2017)

Endoscopic submucosal dissection (ESD) is a minimally invasive technique allowing for the removal of early gastrointestinal (GI) tumors, widely considered as a valid alternative to conventional surgery. However, ESD is technically demanding, and potentially severe complications, such as bleeding and perforation, may occur. Energy-based techniques (e.g., radiofrequency ablation) might offer a potential alternative to ESD. However, their use mandates the ability to predict the damage induced and to identify a "signature" of the complete ablation, without the need for a physical specimen. Ideally, an energy-based procedure should be tunable in order to limit the ablation to the superficial layers, namely mucosa (M) and submucosa (SM), without injuring the muscularis propria (MP), thereby minimizing GI perforation. This experimental study aims to investigate thermal damage induced by Nd:YAG laser on the gastric wall, at different laser settings such as power (P) and time (t). Laser ablation was performed on the stomach wall of 6 Wistar rats. Two powers (2.5W and 1.0W) and 3 exposure times (12s, 6s and 2s) were tested, for a total of 30 ablations. Histological analysis allowed to assess thermal damage, in terms of damage depth (DD) and identification of involved layers. The ratio (R) between DD and the total depth (TD) of target layers (M+SM) was used as an index to evaluate the effectiveness of laser settings. At P=2.5W, MP was damaged (R>1) in the majority of cases (11/15). At P=1.0W, MP was preserved in all tests (R<;1), and rarely (4/15) did the damage reach the whole SM (R=1). Histopathological analysis evidenced that tissue damage was strongly related to the variable tissue thickness. These preliminary results seem to support the fact that endoscopic tunable laser ablation is feasible with a consistent damage/power correlation. Further tests are required to optimize the settings for applications on early GI tumors.
Comment on mr-2022-12 (2022)

<strong class="journal-contentHeaderColor">Abstract.</strong> Polarisation transfer schemes and indirect detection are central to magnetic resonance. Using the trityl radical OX063 and a pulse electron paramagnetic resonance spectrometer operating in the Q-band (35âGHz, 1.2âT), we show here that it is possible to use pulsed dynamic nuclear polarisation (DNP) to transfer polarisation from electrons to protons <i>and back</i>. The latter is achieved by first saturating the electrons and then simply using a reverse DNP step. A variable mixing time between DNP and reverse DNP allows us to investigate the decay of polarisation on protons in the vicinity of the electrons. We qualitatively investigate the influence of solvent deuteration, temperature, and electron concentration. We expect reverse DNP to be useful in the investigation of nuclear spin diffusion and envisage its use in electronânuclear double-resonance (ENDOR) experiments.
High-dose 166Ho-DOTMP in myeloablative treatment of multiple myeloma: pharmacokinetics, biodistribution, and absorbed dose estimation. (2002)

166Ho-DOTMP has physical and pharmacokinetic characteristics compatible with high-dose myeloablative treatment of multiple myeloma.
Facile one-pot green synthesis of Ag–ZnO Nanocomposites using potato peeland their Ag concentration dependent photocatalytic properties (2020)

Herein, a facile green synthesis route was reported for the synthesis of Ag-ZnO nanocomposites using potato residue by simple and cost effective combustion route and investigated the photocatalytic degradation of methylene blue (MB) dye. In the preparation potato extract functioned as a biogenic reducing as well as stabilizing agent for the reduction of Ag + , thus eliminating the need for conventional reducing/stabilizing agents. Ag-ZnO nanocomposites with different Ag mass fractions ranging from 2 to 10% were characterized by using XRD, FT-IR, XPS, SEM, TEM, and UV-Vis spectroscopy. XRD analysis revealed that the as prepared Ag-ZnO nanocomposites possessed high crystallinity with hexagonal wurtzite structure. TEM and SEM images showed that the Ag-ZnO nanocomposites in size ranging from 15 to 25 nm have been obtained, and the particle size was found to increase with the increase in percentage of Ag. FTIR results confirmed the characteristics band of ZnO along with the Ag bands. XPS analysis revealed a pair of doublet with peaks corresponding to Ag and a singlet with peaks corresponding to ZnO. With the increase of concentration of Ag in ZnO, the intensity of NBE emission in the PL spectra was observed to be decrease, resulted to the high photocatalytic activity. Photocatalytic properties of Ag-ZnO nanocomposites evaluated against the MB dye under visible-light irradiation showed superior photodegradation of ~ 96% within 80 min for 2% Ag-ZnO nanocomposites. The apparent reaction rate constant for 2% Ag-ZnO nanocomposites was higher than that of other nanocomposites, which proved to be the best photocatalyst for the maximum degradation of MB. Furthermore, various functional parameters such as dosing, reaction medium, concentration variation were performed on it for better understanding. The enhancement in photocatalytic degradation might be due to the presence of Ag nanoparticles on the surface of ZnO by minimizing the recombination of photo induced charge carriers in the nanocomposites.
Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA (2018)

AT specific heterocyclic cations that bind in the DNA duplex minor groove have had major successes as cell and nuclear stains and as therapeutic agents which can effectively enter human cells. Expanding the DNA sequence recognition capability of the minor groove compounds could also expand their therapeutic targets and have an impact in many areas, such as modulation of transcription factor biological activity. Success in the design of mixed sequence binding compounds has been achieved with N-methylbenzimidazole ( N-MeBI) thiophenes which are preorganized to fit the shape of the DNA minor groove and H-bond to the -NH of G·C base pairs that project into the minor groove. Initial compounds bind strongly to a single G·C base pair in an AT context with a specificity ratio of 50 ( K<sub>D</sub> AT-GC/ K<sub>D</sub> AT) or less and this is somewhat low for biological use. We felt that modifications of compound shape could be used to probe local DNA microstructure in target mixed base pair sequences of DNA and potentially improve the compound binding selectivity. Modifications were made by increasing the size of the benzimidazole N-substituent, for example, by using N-isobutyl instead of N-Me, and by changing the molecular twist by introducing substitutions at specific positions on the aromatic core of the compounds. In both cases, we have been able to achieve a dramatic increase in binding specificity, including no detectible binding to pure AT sequences, without a significant loss in affinity to mixed base pair target sequences.
Reflection spectrophotometry (OxySat-2®) for monitoring oxygen saturation and hematocrit during extracorporeal circulation (1988)

Continuous measurement of sO2 and hematocrit during extracorporeal circulation has become feasible using reflection spectrophotometry. We have compared simultaneous measurements with in-line reflection spectrophotometry (OxySat-2® American Bent-ley), and in-vitro transmission spectrophotometry (OSM3 Hemoximeter® Radiometer) on discrete samples.In 8 patients undergoing open heart surgery during hypothermic extracorporeal circulation with hemodilution arterial and venous sO2 and hematocrit were measured continuous in-line in the extracorporeal circuit. Simultaneous and anaerobically collected blood samples were analyzed within one minute in the OSM3. The relationship between hemoglobin concentration (cHb) measured in the OSM3 and hematocrit (Hct) measured by the OxySat-2 was estimated from a mean cell hemoglobin concentration of 20 mmol·l-1, i.e. Hct (%) = 100 cHb/20.There was a systematic difference between the OxySat-2 and the reference method for sO 2</sb and cHb, the mean difference being: −2.4 s.d.2.8 and-2.1 s.d. 1.7. Linear regression analysis shows the following equations : OxySat-2 = Y, OSM3 = X:sO 2</sb <%): Y= 1.06 · X − 7.6 r = 0.97 n = 122Hct (%): Y = 0.68 · X + 5.5 r= 0.77 n = 122The results indicates that continuous in-line measurements of sO2 and cHb with reflection spectrophotometry are reliable and with clinical acceptable precission and accuracy, provided that the concentration of dyshemoglobins, i.e. carboxy- and methemoglo-bin is negligible.
Mechanism of ischemic contracture in ferret hearts: relative roles of [Ca2+]i elevation and ATP depletion (1990)

When coronary perfusion is interrupted, the diastolic force generated by the myocardium first falls but eventually increases. The delayed rise in force, ischemic contracture, has been attributed either to ATP depletion or to elevation of the intracellular free calcium concentration ([Ca2+]i). To distinguish between these possibilities, we measured [Ca2+]i and ATP concentration [( ATP]) in ferret hearts using nuclear magnetic resonance (NMR) spectroscopy. Mean time-average [Ca2+]i and [ATP] equaled 0.25 microM and 2.7 mumol/g wet wt, respectively, under control perfusion conditions. [Ca2+]i increased and [ATP] fell during total global ischemia. Although [Ca2+]i exceeded the usual systolic levels of 1.7 microM within 20-25 min of ischemia and reached a steady level between 2 and 3 microM by 30-35 min, force only began to rise after 40 min. In contrast, the time required for [ATP] to fall to less than 10% of control levels coincided closely with the onset of contracture. Ischemia in the presence of iodoacetate, an inhibitor of glycolysis, led to a precipitous fall in [ATP] and a concomitant rise in force, both of which preceded any elevation of [Ca2+]i. Thus changes in [Ca2+]i are neither sufficient nor necessary for the initiation of ischemic contracture. We conclude that ATP depletion is primary and that the rise in resting force reflects the formation of rigor cross bridges.
A novel predictor coefficient interpolation approach for lossless compression of images (2011)

This paper presents a novel and generic algorithm for reduction in computational complexity associated with the estimation of LS based predictor. Many lossless compression algorithms used predictor based on Least Squares and its variance for decorrelation of images. However, computational complexity associated with estimation of such predictor is huge. So, in order to reduce the computational complexity, we proposed to estimate a LS based predictor of order p-1 and estimates the coefficients of predictor of order p. We have reduced the predictor order form p to (p - 1) that results into a saving of computational power. We have also reduced the predefined error threshold in EDP and RALP algorithm in order to negotiate the slight loss in prediction accuracy due to synthetically generated prediction coefficient. The proposed algorithm is generic that can be used with most of the LS based lossless compression algorithms reported in literature. Our proposed algorithm gives same prediction quality as compared to when we use the actual prediction coefficient and there is around 25% to 40% reduction in computational complexity.
A Study of Modeling Travelers' Route Choice Behavior and Information Release Strategy (2008)

It is a rational assumption that travelers would not be completely in compliance with the guidance by advanced traveler information systems (ATIS). This paper presents a dynamic programming model for investigating the day-to-day receiving and adjusting process to the information released by ATIS. The dynamic model aims at seeking an optimal information release strategy for minimizing the overall disutility and a logit-based route choice is given on the base of adjusted travel times by travelers. The model is also an optimal control model and solved by solving a series of sequential programs. Numerical results are presented to show that there exists an optimal information release strategy that can drive the flow pattern to a system optimum.
Differentially Private Federated Quantiles with the Distributed Discrete Gaussian Mechanism (2022)

International audience
Silicon Backplane Ferroelectric Liquid Crystal Spatial Light Modulator for Uses Within an Optical Telecommunications Environment (2004)

Liquid crystal on silicon (LCOS) devices are ideal for uses as miniature light modulating elements. They can replace either transmissive LC (TFT) micro-displays or micro-mechanical MEMS and have been extensively used in display applications 1 Johnson, K. M., McKnight, D. J. and Underwood, I. 1993. IEEE Journal of Quant. Electr., 29(2): 699–714. [Crossref], [Web of Science ®] , [Google Scholar]. Pioneering works have proposed adapting them to implement optical communication functions such as optical spatial switches 2 Berthelé, P., Fracasso, B. and Tocnaye, J. L. de Bougrenet de la. 1998. Appl. Opt., 37(23): 5461–5468. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar], 3 Crossland, W. A., Manolis, I. G., Redmond, M. M., Tan, K. L., Wilkinson, T. D., Holmes, M. J., Parker, T. R., Chu, H. H., Croucher, J., Handerek, V. A., Warr, S. T., Robertson, B., Bonas, I. G., Franklin, R., Stace, C., White, H. J., Woolley, R. A. and Henshall, G. 2000. IEEE Journ. Lightwave Technol, 18: 1845–1853. http://dx.doi.org/10.1109%2F50.908753http://www.csa.com/htbin/linkabst.cgi?issn=0733-8724&vol=18&iss=&firstpage=1845[Crossref], [Web of Science ®] , [Google Scholar]. For the first time to our knowledge, a industrial LCOS device has been specifically adapted for telecommunications uses only on a pre-industrial level. We discuss here the relevant specifications and present the optical performance of this preliminary “telco” LCOS prototype. The device is a silicon backplane SXGA ferroelectric liquid crystal spatial light modulator operating in the 1.5 μ m telecom wavelength range. It is used as the beam steering core of an optical free-space switch whose optical and system test results are also presented.
Identification of Brassinolide and Castasterone in Buckwheat (Fagopyrum esculentumMoench) Pollen (1990)

Journal Article Identification of Brassinolide and Castasterone in Buckwheat (Fagopyrum esculentum Moench) Pollen Get access Suguru Takatsuto, Suguru Takatsuto Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Kumiko Omote, Kumiko Omote Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, Japan Search for other works by this author on: Oxford Academic Google Scholar Keiji Gamoh, Keiji Gamoh Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, JapanFaculty of Education, Kochi University, Akebono-cho, Kochi-shi 780, Japan Search for other works by this author on: Oxford Academic Google Scholar Masataka Ishibashi Masataka Ishibashi Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, JapanResearch Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Ltd., 3-31 Shimo, Kita-ku, Tokyo 115, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 3, 1 March 1990, Pages 757–762, https://doi.org/10.1080/00021369.1990.10869991 Published: 01 March 1990 Article history Received: 02 October 1989 Published: 01 March 1990
Electrostatic Capture Following Laser Microdissection for the Preparation of Homogeneous Biological Specimens (2016)

There is an unmet need for researchers in life sciences and clinical pathology to obtain untainted target cells with very high accuracy, which are suitable for subsequent genome and protein analysis. In this paper, an electrostatic capture laser microdissection technology (ECM) is proposed and explained. Following microscopic identification and separation of target cells from the surrounding tissues using laser cutting, the ECM uses electrostatic forces to capture target cells. Validation experiments indicate that ECM can capture a wide assortment of contamination-free homogeneous samples, ranging from very tiny pieces of a few micrometers in diameter to large pieces with a surface area of over 40,000 µm2. Evidence is also provided indicating that uncontaminated homogeneous tissue materials collected by ECM are suitable for further DNA and RNA analysis. This suggests that ECM capture causes little or no identifiable damage to the collected tissues. This technique has significant advantages compared with existing traditional capture methods, such as very low risk of biological sample damage and the fact that it can be applied to both upright and inverted microscopy. The latter allows for separating target cells in tissue culture. ECM usage provides a cost-effective alternative to more traditional laser capture microdissection techniques.
Real-time simultaneous localisation and mapping with a single camera (2003)

Ego-motion estimation for an agile single camera moving through general, unknown scenes becomes a much more challenging problem when real-time performance is required rather than under the off-line processing conditions under which most successful structure from motion work has been achieved. This task of estimating camera motion from measurements of a continuously expanding set of self-mapped visual features is one of a class of problems known as Simultaneous Localisation and Mapping (SLAM) in the robotics community, and we argue that such real-time mapping research, despite rarely being camera-based, is more relevant here than off-line structure from motion methods due to the more fundamental emphasis placed on propagation of uncertainty. We present a top-down Bayesian framework for single-camera localisation via mapping of a sparse set of natural features using motion modelling and an information-guided active measurement strategy, in particular addressing the difficult issue of real-time feature initialisation via a factored sampling approach. Real-time handling of uncertainty permits robust localisation via the creating and active measurement of a sparse map of landmarks such that regions can be re-visited after periods of neglect and localisation can continue through periods when few features are visible. Results are presented of real-time localisation for a hand-waved camera with very sparse prior scene knowledge and all processing carried out on a desktop PC.
Travel Time Prediction Using Multi-layer Feed Forward Artificial Neural Network (2012)

Traffic jam is a major problem in Bangkok and nearby provinces in Thailand. Currently, there have been several attempts to solve this elevating problem by using GPS together with GPRS technologies in tracking and collecting traffic data from vehicles. In this work, we obtained one-month records of GPS data from 297 volunteered vehicles. Using vehicles' velocity as input, we have developed a travel time prediction model using artificial neural network. However, due to the enormous amount of database, we focus on testing our model on a certain major road, inbound of Hwy35 or Thonburi-Paktor. We applied our ANN model in predicting travel time during rush-hour traffic in the morning/evening and non-rush hour traffic on the weekday and weekend. The predicted results from the proposed model can accurately approximate the actual travel time. Furthermore, the predicted travel time during non-rush hour data set are very close to the predicted travel time provided by GoogleMap.