gebhart/patrepeval huggingface dataset:
An investigation of the iron-sulphur proteins of benzene dioxygenase from Pseudomonas putida by electron-spin-resonance spectroscopy (1984)

Benzene dioxygenase from Pseudomonas putida comprises three components, namely a flavoprotein (NADH:ferredoxin oxidoreductase; Mr 81000), an intermediate electron-transfer protein, or ferredoxin (Mr 12000) with a [2Fe-2S] cluster, and a terminal dioxygenase containing two [2Fe-2S] iron-sulphur clusters (Mr 215000), which requires two additional Fe2+ atoms/molecule for oxygenase activity. The ferredoxin and the dioxygenase give e.s.r. signals in the reduced state with rhombic symmetry and average g values of 1.92 and 1.896 respectively. The mid-point redox potentials were determined by e.s.r. titration at pH 7.0 to be -155 mV and -112 mV respectively. The signal from the dioxygenase shows pronounced g anisotropy and most closely resembles those of 4-methoxybenzoate mono-oxygenase from Pseudomonas putida and the [2Fe-2S] 'Rieske' proteins of the quinone-cytochrome c region of electron-transport chains of respiration and photosynthesis.
Migraine, quality of life, and depression (2000)

Subjects with migraine selected from the general population have lower HRQoL as measured by the SF-12 compared with nonmigraine controls. Further, migraine and depression are highly comorbid and each exerts a significant and independent influence on HRQoL.
Dose-dependent Effects of a Glucocorticoid on Prolactin Production (2008)

Glucocorticoids are known to stimulate growth hormone (GH) production but to suppress prolactin (PRL) production. However, previous data were obtained with rather high doses of corticosterone. In this study we examined the effects of various doses (10 (-12) -10 (-7) M) of corticosterone on GH and PRL production in a rat pituitary somatomammotropic cell line, MtT/SM cells, and found that GH mRNA expression was facilitated by high doses (10 (-7) and 10 (-8) M). In contrast, a biphasic effect of corticosterone on PRL mRNA expression and secretion was observed, i.e., high doses (10 (-7) and 10 (-8) M) suppressed and low doses (10 (-12) -10 (-10) M) facilitated them. In an immunofluorescent staining study, the number of PRL immunopositive cells increased with low doses of corticosterone while it decreased with high doses of it, which corresponded to PRL mRNA expression and hormone secretion, respectively. These effects of corticosterone on PRL production were abolished by a glucocorticoid receptor (GR) antagonist, mifepristone. In addition, co-treatment with low doses of corticosterone (10 (-12) -10 (-10) M) and 17beta-estradiol (E(2), 10 nM) additively increased the number of PRL immunopositive cells. Moreover, a 24 h BrdU incorporation experiment suggested that the increase in the number of PRL immunopositive cells treated with low dose corticosterone was caused by novel synthesis of PRL while, on the other hand, that of those treated with E(2) resulted from PRL cell proliferation. Thus, we concluded that corticosterone biphasically regulates PRL production and the sensitivity of E(2) to different degrees.
Joint Pilot Allocation and Robust Beam-Vector Design for Ultra-Dense TDD C-RAN (2017)

This paper deals with the unavailability of full CSI in ultra-dense user-centric TDD C-RAN. To reduce the channel training overhead, we consider the incomplete CSI case, where only large-scale inter-cluster CSI is available. Channel estimation for intra-cluster CSI is also considered, where we formulate a joint pilot allocation and user equipment (UE) selection problem to maximize the number of admitted UEs with fixed number of pilots. A novel pilot allocation algorithm is proposed by considering the multi-UE pilot interference. Then, we consider robust beam-vector optimization problem subject to UEs' data rate requirements and fronthaul capacity constraints, where the channel estimation error and incomplete inter-cluster CSI are considered. Simulation results demonstrate its superiority over the existing algorithms.
Group IV semiconductor nanowire arrays: different flavors of epitaxy (2009)

Epitaxy can be used to direct nanowire chemical vapor deposition and to influence the crystallographic orientation of nanowires during their nucleation and growth via the vapor-liquid-solid mechanism. Under some circumstances, the influence of epitaxy competes with capillary effects and the influence of nanoparticle catalyst coarsening and surface impurities on nanowire orientation selection. We have investigated rapid thermal chemical vapor deposition of epitaxial Ge nanowires and have used it to separately study nanowire nucleation and growth. This has given important insights into deep-subeutectic Ge nanowire growth using Au catalyst particles. These Ge nanowires have also been studied as the cores in epitaxial Ge core/Si shell nanowires. We have studied the conditions under which strain driven surface roughening and dislocations formation occurs in these coaxial nanowire heterostructures. Recent results indicate that suppression of Si shell surface roughening can lead to fully strained, coherent core/shell nanowires.
Supplementary Figure 1 from An Oncogenic Role for <i>ETV1</i> in Melanoma (2023)

Supplementary Figure 1 from An Oncogenic Role for &lt;i&gt;ETV1&lt;/i&gt; in Melanoma
Using NextRAD sequencing to infer movement of herbivores among host plants (2017)

Herbivores often move among spatially interspersed host plants, tracking high-quality resources through space and time. This dispersal is of particular interest for vectors of plant pathogens. Existing molecular tools to track such movement have yielded important insights, but often provide insufficient genetic resolution to infer spread at finer spatiotemporal scales. Here, we explore the use of Nextera-tagmented reductively-amplified DNA (NextRAD) sequencing to infer movement of a highly-mobile winged insect, the potato psyllid (Bactericera cockerelli), among host plants. The psyllid vectors the pathogen that causes zebra chip disease in potato (Solanum tuberosum), but understanding and managing the spread of this pathogen is limited by uncertainty about the insect's host plant(s) outside of the growing season. We identified 1,978 polymorphic loci among psyllids separated spatiotemporally on potato or in patches of bittersweet nightshade (S. dulcumara), a weedy plant proposed to be the source of potato-colonizing psyllids. A subset of the psyllids on potato exhibited genetic similarity to insects on nightshade, consistent with regular movement between these two host plants. However, a second subset of potato-collected psyllids was genetically distinct from those collected on bittersweet nightshade; this suggests that a currently unrecognized source, i.e., other nightshade patches or a third host-plant species, could be contributing to psyllid populations in potato. Oftentimes, dispersal of vectors of pathogens must be tracked at a fine scale in order to understand, predict, and manage disease spread. We demonstrate that emerging sequencing technologies that detect genome-wide SNPs of a vector can be used to infer such localized movement.
Lichtinduzierte Reaktionen, XI: Photochemische Öffnung linear‐konjugierter Cyclohexadienone zu den seco‐isomeren Dienylketenen (1976)

Abstract Am Beispiel von 6,6‐Dimethyl‐2,4‐cyclohexadienon ( 1 ) wurde die lichtinduzierte Cyclo / seco ‐Isomerisierung linear‐konjugierter Cyclohexadienone studiert. Durch UV‐Bestrahlung von 1 in aprotischen Lösungsmitteln bei Temperaturen &lt;−60°C läßt sich das in einer spektroskopisch einheitlichen Reaktion entstehende, bei Raumtemperatur kinetisch instabile Dienylketen 4 „einfrieren”︁. Ir‐, NMR‐ und Elektronenabsorptions‐Spektroskopie bei &lt;−60°C belegen die Struktur des Transienten sowie die praktisch vollständig verlaufende, wärmeinduzierte seco / cyclo ‐Isomerisierung zu 1 . Zusätzlich zu oder statt der Fähigkeit zu recyclisieren lagert 4 protische Nucleophile an. Wird 1 in Gegenwart von Wasser oder Cyclohexylamin mit UV‐Licht bestrahlt, so erhält man in einer spektroskopisch einheitlichen Reaktion 2a oder b mit Ausbeuten von &gt; 95%. Ihre Konstitution und Ligandenorientierung an der zweifach substituierten Doppelbindung wurden durch Folgeprodukte und Spektren sichergestellt. Da 1 * keine nachweisbare Emission erkennen läßt, müssen für die Identifizierung des photoreaktiven Elektronenisomeren sowie des zugehörigen Spinisomeren andere Indizien herangezogen werden. die von der Wellenlänge des eingestrahlten Lichts (313 nm: π*, π‐Anregung; 365 nm: π*, n‐Anregung) unabhängige Quantenausbeute spricht für das Energetisch tiefer liegende π*, n‐Elektronenisomere, die nicht stattfindende Reaktionslöschung durch Piperylen für das Auftreten des Singulett‐Spinisomeren, Ohne daß ein extrem kurzlebiges Triplett‐Spinisomeres ausgeschlossen werden kann. Die Apparatur zur Bestimmung der Quantenausbeute sowie die Küvette zur spektroskopischen Messung im IR‐Bereich bei variabler Temperatur werden in einzelnen beschrieben.
[Comparative hemodynamic effects of 2 vasodilators: dihydralazine and diltiazem in permanent essential arterial hypertension]. (1982)

Cardiac hemodynamic and diameter, blood flow velocity, volumic flow of the brachial artery measured by pulsed Doppler, were studied before and after diltiazem administration in comparison with dihydralazine in hypertensive patients. After diltiazem administration, blood pressure and total peripheral resistance significantly decreased (P less than 0.001) while cardiac index and heart rate increased (P less than 0.01). After 25 minutes perfusion cardiac output and heart rate returned toward control values, while blood pressure and total peripheral resistance remained decreased. The result contrasted with those observed after dihydralazine, which induced an increase in cardiac index and heart rate. The caliber of the brachial artery decreased significantly (P less than 0.001) after dihydralazine and increased after diltiazem (P less than 0.01). This study shows that 1). The antihypertensive effect of diltiazem was due to a fall in total peripheral resistance associated with a transient baroreflex mediated tachycardia, and 2) diltiazem dilated also large arteries.
ChemInform Abstract: Copper(II) Acetate as a Building Block of Heterometallic Dinuclear Complexes with a Cu‐Mo and Cu‐W Bond. The X‐Ray Crystal Structures of C5H5(CO)2Mo(μ‐O2CMe)2Cu(4‐MeC5H4N) and C5H5W(CO)3OC(O)Me. (1987)

Abstract The preparations and reactivity of the heterometallic dinuclear complexes (I) are described.
Military and Executive Experience Supports Lessons Learned (2002)

DANIEL J. SNYDER, FACHE, IS CHIEF OPERATING OFFICER OF THE URBAN CENTRAL REGION FACILITIES OF INTERMOUNTAIN HEALTH CARE AND CHIEF EXECUTIVE OFFICER OF IHC'S FLAGSHIP MEDICAL CENTER IN SALT LAKE CITY, UTAH.
Reliability of Two Clinical Scoring Systems for Dental Erosive Wear (2010)

The aim of the study was to evaluate and compare two dental erosive wear scoring systems, the Visual Erosion Dental Examination (VEDE) and Basic Erosive Wear Examination (BEWE). Seventy-four tooth surfaces (photographs) and 562 surfaces (in participants) were scored by 5 (photographs) or 3 (in participants) clinicians using both scoring systems. The surfaces in the photographs were scored twice. The level of agreement was measured by weighted kappa (kappa(w)). Inter- and intraexaminer agreement showed small variations between the examiners for both systems when scoring the photographs. Slightly higher mean kappa(w) values were found for VEDE (kappa(w) = 0.77) compared with BEWE (kappa(w) = 0.69). When scoring the surfaces in the clinical examination the mean kappa(w) values for the two systems were equal (kappa(w) = 0.73). Interexaminer agreement using VEDE was calculated to see how differentiation between enamel and dentine lesions influenced the variability. The highest agreement was found for score 0 (sound, 86%) and score 3 (exposure of dentine, 67%), while the smallest agreement was shown for score 1 (initial loss of enamel, 30%) and score 2 (pronounced loss of enamel, 57%). The reliability of the two scoring systems proved acceptable for scoring the severity of dental erosive wear and for recording such lesions in prevalence studies. The greatest difficulties were found when scoring enamel lesions, especially initial lesions, while good agreement was observed when examining sound surfaces (score 0) and dentine lesions (score 3).
A Comparison of Diarrheal Severity Scores in the MAL‐ED Multisite Community‐Based Cohort Study (2016)

Community-based diarrheal severity scores are predictive of relevant child health outcomes. Because they require no assumptions about health care access or utilization, they are useful in refining estimates of the burden of diarrheal disease, in estimating the effect of disease control interventions, and in triaging children for referral in low- and middle-income countries in which the rates of morbidity and mortality after diarrhea remain high.
Track on Computer Networks (2008)

On behalf of the Program Committee of the Track on Computer Networks of The 23rd Annual ACM Symposium on Applied Computing (ACM SAC 2008), it is our great pleasure to welcome you to the ACM SAC 2008, held from March 16 to March 20, 2008, in Fortaleza, Ceara, Brazil. In recent years, significant advances in computer networks have been made throughout the world. This track aims to be a forum for scientists, engineers and practitioners, in academia and industry to share new ideas, experiences and results, and to present their latest findings in any aspects of computer networks.
Oxidation of alcohols by metallic nitrates supported on silica gel (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of alcohols by metallic nitrates supported on silica gelTakeshi Nishiguchi and Fumi AsanoCite this: J. Org. Chem. 1989, 54, 7, 1531–1535Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/jo00268a011https://doi.org/10.1021/jo00268a011research-articleACS PublicationsRequest reuse permissionsArticle Views603Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pt and Ru X-ray Absorption Spectroscopy of PtRu Anode Catalysts in Operating Direct Methanol Fuel Cells (2006)

In situ X-ray absorption spectroscopy, ex situ X-ray fluorescence, and X-ray powder diffraction enabled detailed core analysis of phase segregated nanostructured PtRu anode catalysts in an operating direct methanol fuel cell (DMFC). No change in the core structures of the phase segregated catalyst was observed as the potential traversed the current onset potential of the DMFC. The methodology was exemplified using a Johnson Matthey unsupported PtRu (1:1) anode catalyst incorporated into a DMFC membrane electrode assembly. During DMFC operation the catalyst is essentially metallic with half of the Ru incorporated into a face-centered cubic (FCC) Pt alloy lattice and the remaining half in an amorphous phase. The extended X-ray absorption fine structure (EXAFS) analysis suggests that the FCC lattice is not fully disordered. The EXAFS indicates that the Ru-O bond lengths were significantly shorter than those reported for Ru-O of ruthenium oxides, suggesting that the phases in which the Ru resides in the catalysts are not similar to oxides.
Susceptibility of germ-free rats to the hepatotoxic effects of dimethylnitrosamine or dimethylamine plus sodium nitrite administered orally. (1983)

The influence of intestinal microflora on the hepatotoxic effects of dimethylnitrosamine (DMN) or dimethylamine (DMA) plus NaNO2 was studied by comparing the degree of liver necrosis and the levels of serum alanine aminotransferase (GPT) and aspartate aminotransferase (GOT) in germ-free and conventional male Wistar rats (320 to 340 g). In one experiment, both germ-free and conventional rats were intubated with DMN in respective doses of 8, 9, and 10 mg/kg of body weight, while in another experiment, both groups were intubated with DMA (1500 mg/kg) plus NaNO2 (100 mg/kg). In both experiments, 48 hr after intubation, there was a marked difference in the degree of liver necrosis and the levels of serum GPT and GOT between the groups. In particular, a dose of 8 mg of DMN or 1500 mg of DMA plus 100 mg of NaNO2 produced severe liver necrosis in the majority of germ-free rats, while the same dose did not produce any detectable liver necrosis in the majority of conventional rats. At a dose of 8 mg, serum GPT and GOT levels were raised to 22 and 15 times normal values, respectively, in germ-free rats, but only to about twice the normal values for both levels in conventional rats. At the combination dose of DMA plus NaNO2, the levels of serum GPT and GOT were raised to 40 and 30 times normal values, respectively, in germ-free rats, while both levels remained almost normal in conventional rats. Thus, the results indicated that the liver of the germ-free state was far more susceptible to the acute toxic effects of DMN as well as DMA plus NaNO2 administration at a certain dose range than was the liver of the conventional state, suggesting the influence of the absence of microflora.
Piezoelectric Properties of Spark-Plasma-Sintered (Na0.5K0.5)NbO3–PbTiO3Ceramics (2002)

In the search for high-performance piezoelectrics, (1-y)(Na0.5K0.5)NbO3–yPbTiO3 (y≤0.50) solid solution has been prepared using the spark-plasma-sintering method. Dielectric investigation reveals that both the ferroelectric phase transition temperatures and the peak value of the dielectric constant are strongly suppressed in the low y range. However, improved electromechanical coupling constants are observed at the same y range. These properties are explained by considering factors such as composition, crystal structure, ferroelectric domain microstructure, and poling conditions.
Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor α Chain (2008)

Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin are members of the four-helix bundle cytokine family. These proteins signal through a common tripartite receptor composed of leukemia inhibitory factor receptor, gp130, and ciliary neurotrophic factor receptor alpha. Binding to ciliary neurotrophic factor receptor alpha occurs through an interaction site located at the C terminus of the cytokine AB loop and alphaD helix, known as site 1. In the present study, we have generated a model of neuropoietin and identified a conserved binding site for the three cytokines interacting with ciliary neurotrophic factor receptor alpha. To identify the counterpart of this site on ciliary neurotrophic factor receptor alpha, its cytokine binding domain was modeled, and the physicochemical properties of its surface were analyzed. This analysis revealed an area displaying properties complementary to the site 1 of ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin. Based on our computational predictions, residues were selected for their potential involvement in the ciliary neurotrophic factor receptor alpha binding epitope, and site-directed mutagenesis was carried out. Biochemical, cell proliferation, and cell signaling analyses showed that Phe(172) and Glu(286) of ciliary neurotrophic factor receptor alpha are key interaction residues. Our results demonstrated that ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on ciliary neurotrophic factor receptor alpha.
Heterodyne method for high specificity gas detection (1971)

This paper describes a new technique for measuring trace quantities of gases. The technique involves the use of a reference cell (containing a known amount of the gas being sought) and a sample cell (containing an unknown amount of the same gas) wherein the gas densities are modulated. Light passing through the two cells in sequence is modulated in intensity at the vibrational-rotational lines characteristic of the absorption spectrum for the gas of interest. Since the absorption process is nonlinear, modulating the two absorption cells at two different frequencies gives rise to a heterodyning effect, which in turn introduces sum and difference frequencies in the detected signal. Measuring the ratio of the difference frequency signal for example, to the signal introduced by the reference cell provides a normalized measure of the amount of the gas in the sample cell. The readings produced are thereby independent of source intensity, window transparency, and detector sensitivity. Experimental evaluation of the technique suggests that it should be applicable to a wide range of gases, that it should be able to reject spurious signals due to unwanted gases, and that it should be sensitive to concentrations of the order of 10 to the minus 8th power when used with a sample cell of only 20 cm length.
Clarifying the application of Weibull Statistics for Determining the Stress state of A Fibre from Fragmentation Tests (1993)

A novel technique was recently introduced in our laboratories for the measurement of the compressive strength of single fibres, based on a modified configuration of the single fibre composite fragmentation test. In particular, the effect of the length of the embedded fibre on its compressive strength was assessed for the first time, based on Weibull statistics considerations. Moreover, during the sample manufacturing stage, a fibre can break in compression due to induced cooling stresses, rather than mechanical stresses, which can be determined from the fragmentation phenomenon. In this note, improved analyses of such compressive fragmentation effects are presented and discussed.
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs (2019)

SUMMARY Circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease. Protective antibodies recognize the central PfCSP domain, but our understanding of how parasite inhibition is associated with recognition of this domain and with the evolution of potent antibodies remains scattered. Here, we characterized the epitope specificity of 200 human monoclonal PfCSP antibodies. We show that the majority of PfCSP antibodies bind to NANP and NANP-like motifs with different preferences and define the molecular basis for recognition. Epitope cross-reactivity evolved with increasing antibody affinity around a conserved (N/D)P-NANP-N(V/A) core. High affinity to this motif, but not binding to NANP-like motifs, was associated with parasite inhibition and protection. Thus, NANP drives the development of potent PfCSP antibodies independently of their cross-reactivity profile, a finding with direct implications for the design of a second-generation PfCSP-based malaria vaccine. HIGHLIGHTS The majority of human PfCSP antibodies recognize multiple epitopes NANP affinity maturation drives the evolution of cross-reactive PfCSP antibodies Preferential PfCSP antibody binding to a conserved core motif High affinity not epitope specificity is associated with PfCSP antibody potency