gebhart/patrepeval huggingface dataset:
Effect of Alloying Additions of Aluminum and Iron on the Creep Resistance of Ti-12Cr (2019)

Abstract In this study, the creep properties of three titanium alloys were experimentally obtained at different applied stresses and at 683 K. X-ray diffraction and optical and electron microscopy were used to help characterize the microstructure before and after creep deformation and to show how changes in hardness correlate with the precipitation of α and ω phases in the β titanium matrix. The results of the study show that Ti-12Cr-1Fe-3Al is the most creep resistant followed by Ti-12Cr-3Al and Ti-12Cr.
PCR Analysis of IgH and BCL2 Gene Rearrangement in the Diagnosis of Follicular Lymphoma in Lymph Node Fine-needle Aspiration (1997)

In order to improve the cytomorphologic diagnosis of malignant lymphoma on lymph node fine-needle aspiration (FNA), and to make a confident discrimination between low-grade follicular non-Hodgkin's lymphoma (NHL) and lymphoid hyperplasia, polymerase chain reaction (PCR) analysis was performed of the Ig CDR3 region and BCL2 breakpoint region in 25 nonselected cases of malignant lymphoma (17 NHL and 8 Hodgkin's disease [HD]) with histologic control, and 22 cases of lymph nodal hyperplasia with histologic and/or clinical control. Among lymphomas, IgH monoclonality was detected in 7 (77%) of 9 NHLs and BCL2 rearrangement in 3 (17.6%) of 17 NHLs, all of which were follicular centroblastic-centrocytic (FCBCC). Three BCL2/JH negative FCBCC cases were monoclonal for CDR3. Neither IgH monoclonality nor BCL2 rearrangement were found in HD. Among cytologically diagnosed lymphoid hyperplasias, one IgH polyclonal case was considered false-negative, being histologically diagnosed as lymphoplasmacytic NHL on the subsequent excisional biopsy. Another 4 cases (2 BCL2 rearranged and 2 monoclonal for IgH) were considered false-positive on the basis of histologic features or clinical control. These data indicate that the combined PCR analysis of IgH and BCL2 rearrangements can confirm a cytologic diagnosis of lymphoma in FNAs while, due to the occurrence of both false-positive and false-negative results, it is of limited value in the distinction between follicular lymphoma and lymphoid hyperplasia without morphologic or clinical support.
Nonlinear petrophysical amplitude variation with offset inversion with spatially variable pore aspect ratio (2022)

ABSTRACT Petrophysical amplitude variation with offset (AVO) inversion, which combines a rock-physics model and prestack inversion, aims at effectively quantifying reservoir-property parameters from prestack seismic data. However, for a reservoir with complex pore structures, this approach may suffer from difficulties in rock-physics modeling, which hinders solving the relevant inverse problem. We have proposed a petrophysical AVO inversion method that considers the complex pore structures within reservoir rocks. The method integrates a differential effective medium model, the Gassmann equation, and the exact Zoeppritz equation as the forward operator. In particular, the pore complexity is addressed by favoring the spatial variation of pore type. Differing from conventional sequential inversion methods, the pore-type variation is introduced by updating the aspect ratio together with the reservoir parameters during the inversion process. To enhance the stability of the results, the estimation of aspect ratio and reservoir parameters is jointly conditioned to seismic and elastic data under a Bayesian framework, which leads to the objective function with joint data misfit terms. The objective function is optimized with a simulated annealing algorithm that includes the full nonlinearity of the forward operator. The proposed method is demonstrated by testing and applying on a carbonate reservoir. It generally outperforms methods that are either purely conditioned on the seismic data or based on a constant aspect ratio.
Delayed Desensitization of α2-Adrenoceptor-Mediated Platelet Aggregation in Depressed Patients (1993)

After prolonged exposure to epinephrine, platelets are observed to desensitize alpha 2-adrenoceptor-mediated aggregation responses in vitro. Herein, this phenomenon was studied as a possible in vitro model for alpha 2-adrenoceptor dysregulation in depression. Platelet-rich plasmas obtained from 22 unipolar depressed patients and 25 healthy subjects were preincubated with 20 mumol/L of epinephrine for various lengths of time prior to stirring. By comparing the subsequent extents of aggregation, we observed significantly less desensitization at 4, 20, 30, or 60 minutes postepinephrine exposure (p < or = .05) in depressed patients as compared to healthy controls. This blunted desensitization appeared to be due to a delayed onset of desensitization during the first 0.5 to 2 minutes after epinephrine exposure, since thereafter, the monoexponential desensitization rate did not differ in depressed patients, but the extent of desensitization remained less as compared to healthy subjects. The extent of desensitization was correlated (r = -0.48, p = .02) with the density (Bmax) of the alpha 2-adrenoceptor high-affinity state, as detected in undesensitized platelet membranes by p125I-clonidine binding. An elevation was also observed in the density of nonadrenergic p125I-clonidine-binding sites (putative imidazoline I1 sites) in platelet membranes from depressed patients compared to healthy control subjects. Following treatment with desipramines, the patients (n = 15) displayed more normal (nonblunted) extents of desensitization of aggregation, and the Bmax values for the putative I1 sites were at the levels of healthy controls. If similar aberrations exist in neurons of depressed patients, this may explain a dysregulation of the noradrenergic system believed to underlie depression.
Altered Recruitment of Motor Cortex Neuronal Activity During the Grasping Phase of Skilled Reaching in a Chronic Rat Model of Unilateral Parkinsonism (2019)

Parkinson's disease causes prominent difficulties in the generation and execution of voluntary limb movements, including regulation of distal muscles and coordination of proximal and distal movement components to achieve accurate grasping. Difficulties with manual dexterity have a major impact on activities of daily living. We used extracellular single neuron recordings to investigate the neural underpinnings of parkinsonian movement deficits in the motor cortex of chronic unilateral 6-hydroxydopamine lesion male rats performing a skilled reach-to-grasp task the. Both normal movements and parkinsonian deficits in this task have striking homology to human performance. In lesioned animals there were several differences in the activity of cortical neurons during reaches by the affected limb compared with control rats. These included an increase in proportions of neurons showing rate decreases, along with increased amplitude of their average rate-decrease response at specific times during the reach, suggesting a shift in the balance of net excitation and inhibition of cortical neurons; a significant increase in the duration of rate-increase responses, which could result from reduced coupling of cortical activity to specific movement components; and changes in the timing and incidence of neurons with pure rate-increase or biphasic responses, particularly at the end of reach when grasping would normally be occurring. The changes in cortical activity may account for the deficits that occur in skilled distal motor control following dopamine depletion, and highlight the need for treatment strategies targeted toward modulating cortical mechanisms for fine distal motor control in patients.<b>SIGNIFICANCE STATEMENT</b> We show for the first time in a chronic lesion rat model of Parkinson's disease movement deficits that there are specific changes in motor cortex neuron activity associated with the grasping phase of a skilled motor task. Such changes provide a possible mechanism underpinning the problems with manual dexterity seen in Parkinson's patients and highlight the need for treatment strategies targeted toward distal motor control.
Microwave Dielectric Properties of Ba4(Nd28/3-yRy)Ti18O54 (R = Eu, Dy, Ho, Er and Yb) Solid Solutions (1999)

We have investigated the formation and the microwave dielectric properties of the Ba 4 (Nd 28/3- y R y )Ti 18 O 54 ( R = Eu, Dy, Ho, Er and Yb) solid solutions in which R ions are substituted for Nd ions in Ba 6-3 x Nd 8+2 x Ti 18 O 54 solid solutions with x =2/3. Based on the change of the volume of the unit cell, it was inferred that Eu, Dy, Ho and Er ions substituted into rhombic A 1-sites, but Yb ions did smaller sites such as B -sites and C -sites after substituting A 1-sites. The quality factor ( Q · f ) improved as the ionic radius of substituted R ions increased. In the Eu series, the best Q · f value of 10405 GHz was obtained. The temperature coefficients of the reasonant frequency (τ f ) in the Dy, Ho and Er series were improved by more than 50%, but the dielectric constant ( ε r ) showed only a nominal change of about 3–4 in the vicinity of 80.
Automated DNA-preparation system for bacteria out of air sampler liquids (2012)

Preventing bacterial contaminations is a significant challenge in applications across a variety of industries, e.g. in food processing, the life sciences or biohazard detection. Here we present a fully automated lab-on-a-chip system wherein a disposable microfluidic chip moulded by polymeric injection is inserted into an operating device. Liquid samples, here obtained from an air sampler, can be processed to extract and lyse bacteria, and subsequently to purify their DNA using a silica matrix. After the washing and elution steps, the DNA solution is dispensed into a reaction vessel for further analysis in a conventional laboratory polymerase chain reaction (PCR) device. We demonstrate the workability and efficiency of our approach with results from a 9 ml liquid sample spiked with E. coli.
Insulin resistance is independently associated with significant hepatic fibrosis in Asian chronic hepatitis C genotype 2 or 3 patients (2011)

In this subgroup study of Asian-region HCV genotype 2 or 3 patients, insulin resistance, along with age, cholesterol levels and necro-inflammation, but not steatosis may be associated with significant hepatic fibrosis.
Nitric Oxide Detection with Glassy Carbon Electrodes Coated with Charge-different Polymer Films (2005)

Trace amounts of nitric oxide (NO) have been determined in aqueous phosphate buffersolutions (pH=7.4) by using a glassy carbon electrode coated with three charge-different polymerfilms. The glassy carbon electrode was coated first with negatively charged Nafion film containingtetrakis(pentafluorophenylporphyrin) iron(III) chloride (Fe(III)TPFPP) as the NO oxidation catalyst,and then with positively charged poly(acrylamide-co-diallyldimethylammonium chloride) (PADDA)and with neutral poly(dimethylsiloxane) (silicone) at the outermost layer. This polymer-coatedelectrode showed an excellent selectivity towards NO against possible concomitants in blood such asnitrite, ascorbic acid, uric acid, and dopamine. All current ratios between each concomitant and NOat the cyclic voltammogram was in 10-3 ~ 10-4. This type of electrode showed a detection limit of80 nM for NO. It was speculated from the electrochemical study in methanol that high-valent oxoiron(IV) of Fe(TPFPP) participated in the catalytic oxidation of NO.
Studies on Novel Anti-jamming Technique of Unmanned Aerial Vehicle Data Link (2008)

Based on the M-ary spread spectrum (M-ary-SS), direct sequence spread spectrum (DS-SS), and orthogonal frequency division multiplex (OFDM), a novel anti-jamming scheme, named orthogonal code time division multi-subchannels spread spectrum modulation (OC-TDMSCSSM), is proposed to enhance the anti-jamming ability of the unmanned aerial vehicle (UAV) data link. The anti-jamming system with its mathematical model is presented first, and then the signal formats of transmitter and receiver are derived. The receiver's bit error rate (BER) is demonstrated and anti-jamming performance analysis is carried out in an additive white Gaussian noise (AWGN) channel. Theoretical research and simulation results show the anti-jamming performance of the proposed scheme better than that of the hybrid direct sequence frequency hopping spread spectrum (DS/FH SS) system. The jamming margin of the OC-TDMSCSSM system is 5 dB higher than that of DS/FH SS system under the condition of Rician channel and full-band jamming, and 6 dB higher under the condition of Rician channel environment and partial-band jamming.
Safe two‐plasmid production for the first clinical lentivirus vector that achieves >99% transduction in primary cells using a one‐step protocol (2004)

We report the design of a unique two-plasmid production system for the first lentiviral vector to be evaluated in humans, VRX496. VRX496 is an optimized VSV-G pseudotyped vector derived from HIV-1 that expresses antisense to the HIV envelope gene. We found that a two-plasmid approach to production resulted in higher vector production titers when compared with a three-plasmid approach, which is particularly important for vector production at the large scale. Therefore, we carefully designed a single packaging construct, VIRPAC, for safety by reducing its homology with VRX496 and by insertion of functionally validated genetic elements designed to reduce the risk of generation of a replication-competent lentivirus (RCL). A native cis-acting ribozyme is used to prevent read through into the envelope gene from the upstream gag-pol genes in the packaging vector, thus preventing RNAs containing gag-pol and env together for comparable safety to a three-plasmid system. We demonstrate that there is no significant in vivo vector mobilization using a primary SCID-hu mouse transplantation model, which correlates with the presence of an anti-HIV payload and suggests that inclusion of antisense may be a useful tool to restrict mobilization in other vector constructs. Gene transfer is achieved using a one-step transduction procedure that is simple and clinically translatable, which reaches stable transduction efficiencies of >99% in CD4+ T lymphocytes within 3 days of culture initiation.
Differences in osteonal micromorphology between tensile and compressive cortices of a bending skeletal system: Indications of potential strain‐specific differences in bone microstructure (1994)

These osteonal microstructure and cortical porosity differences may be adaptations related to regional differences in strain mode and/or strain magnitude. This may be related to the disparity in mechanical properties of compact bone in tension vs. compression. These differences may reflect a capacity of bone to process local and regional strain-related information.
"I regretted the minute I pressed share" (2011)

We investigate regrets associated with users' posts on a popular social networking site. Our findings are based on a series of interviews, user diaries, and online surveys involving 569 American Facebook users. Their regrets revolved around sensitive topics, content with strong sentiment, lies, and secrets. Our research reveals several possible causes of why users make posts that they later regret: (1) they want to be perceived in favorable ways, (2) they do not think about their reason for posting or the consequences of their posts, (3) they misjudge the culture and norms within their social circles, (4) they are in a "hot" state of high emotion when posting, or under the influence of drugs or alcohol, (5) their postings are seen by an unintended audience, (6) they do not foresee how their posts could be perceived by people within their intended audience, and (7) they misunderstand or misuse the Facebook platform. Some reported incidents had serious repercussions, such as breaking up relationships or job losses. We discuss methodological considerations in studying negative experiences associated with social networking posts, as well as ways of helping users of social networking sites avoid such regrets.
Encoder implementation for FAMC (2008)

MPEG 85 : 85th Meeting Moving Picture Experts Group, July 21-25, Hannover, Germany. Report ISO/IEC JTC 1/SC 29/WG 11 N9963
Strong Coupling between Mechanical Modes in a Nanotube Resonator (2012)

We report on the nonlinear coupling between the mechanical modes of a nanotube resonator. The coupling is revealed in a pump-probe experiment where a mode driven by a pump force is shown to modify the motion of a second mode measured with a probe force. In a second series of experiments, we actuate the resonator with only one oscillating force. Mechanical resonances feature exotic line shapes with reproducible dips, peaks, and jumps when the measured mode is commensurate with another mode with a frequency ratio of either 2 or 3. Conventional line shapes are recovered by detuning the frequency ratio using the voltage on a nearby gate electrode. The exotic line shapes are attributed to strong coupling between the mechanical modes. The possibility to control the strength of the coupling with the gate voltage holds promise for various experiments, such as quantum manipulation, mechanical signal processing, and the study of the quantum-to-classical transition.
Correction for artifacts induced by B0 and B1 field inhomogeneities in pH‐sensitive chemical exchange saturation transfer (CEST) imaging (2007)

Chemical exchange saturation transfer (CEST) imaging provides an indirect detection mechanism that allows quantification of certain labile groups unobservable using conventional MRI. Recently, amide proton transfer (APT) imaging, a variant form of CEST imaging, has been shown capable of detecting lactic acidosis during acute ischemia, providing information complementary to that of perfusion and diffusion MRI. However, CEST contrast is usually small, and therefore, it is important to optimize experimental conditions for reliable and quantitative CEST imaging. In particular, CEST imaging is sensitive to B(0) and B(1) field, while on the other hand; field inhomogeneities persist despite recent advances in magnet technologies, especially for in vivo imaging at high fields. Consequently, correction algorithms that can compensate for field inhomogeneity-induced measurement errors in CEST imaging might be very useful. In this study, the dependence of CEST contrast on field distribution was solved and a correction algorithm was developed to compensate for field inhomogeneity-induced CEST imaging artifacts. In addition, the proposed algorithm was verified with both numerical simulation and experimental measurements, and showed nearly complete correction of CEST imaging measurement errors caused by moderate field inhomogeneity.
Coordinated LTE uplink radio interface scheduling (2013)

Long Term Evolution (LTE) promises substantially higher radio interface throughput compared to 3G access tech-nologies. Sometimes, the bandwidth demands of a time varying LTE user traffic cannot be fulfilled by the existing transport network either due to the limited capacity or because of the inaccuracies involved in the transport link bandwidth dimensioning. This often results in a congestion situation in the transport network. In this study a novel congestion control scheme is introduced for the LTE uplink which works based on the coordination between the limited transport network capacity and the time varying radio interface capacity. The proposed mechanism operates at the eNB where the two network interfaces can be monitored in order to efficiently minimize the congestion situations. The coordination based congestion control algorithm is implemented in an LTE network simulator and its performance is studied for various system load configurations. The simulation results confirm that the proposed algorithm effectively mitigates the congestion and helps achieve an improved uplink application performance. Furthermore, a significant application performance gain is also observed for the downlink applications when the congestion in the uplink is controlled.
Cardiac Functional Evaluation Using Vector Velocity Imaging After Chemotherapy Including Anthracyclines in Children With Cancer (2009)

Anthracycline therapy, even low-dose, can induce changes in regional wall function before global dysfunction. Also, the strain and SR obtained from VVI may be useful for early detection of these changes.
Pharmacological study on anti-aging effects of Seamin powders (2005)

Objective To investigate the anti-aging effects of Seamin powders. Methods In anti-oxidation test, malondialdehyde (MDA) content , total superoxide dismutase (SOD) activity in serum from mice treated with various doses of Seamin powders were detected; in drosophila melanogaster survival test, survival time of drosophila melanogaster fed on media containing various concentrations of Seamin powders were observed and recorded, and average life span, average maximum life span and median death time were counted. At the same time, the effects of Seamin powders on body weight, temperature and survival time of swimming in cold water in yang-deficiency mice, the abilities of anti-tired and cold-resistant in spleen-hypofunction mice were observed. Results Seamin powders could significantly reduce serum MDA content in aged mice, keep body temperature and prolong the survival time of swimming in cold water in yang-deficiency mice and also extend the survival and swimming time in spleen-hypofunction mice. But it had no prominent effects on SOD activity in serum of aged mice and the average life span and average maximum life span of drosophila melanogaster. Conclusion Seamin powders have the effects of anti-oxidation, anti-stress, but have no function of prolong the life span in drosophila melanogaster.
WITHDRAWN: Editor's Forum (2015)

The Publisher regrets that this article is an accidental duplication of an article that has already been published in <Redox Biology 5 (2015) 409-412>, http://dx.doi.org/10.1016/j.redox.2015.08.002, http://dx.doi.org/10.1016/j.redox.2015.08.003, http://dx.doi.org/10.1016/j.redox.2015.08.004. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy
TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma (2019)

SUMMARY Transcriptional network is controlled by master transcription factors (TFs) and cis -regulatory elements through interacting with target sequences and recruiting epigenetic regulators. By integration of enhancer profiling and chromatin accessibility, we establish super-enhancer (SE) mediated core regulatory circuitry (CRC) for esophageal squamous cell carcinoma (ESCC) and identify tumor cells-dependent CRC TFs-TP63, SOX2 and KLF5. They preferentially co-occupy SE loci and form a positive interconnected auto-regulatory loop through SEs to orchestrate chromatin and transcriptional programming. SE-associated oncogene- ALDH3A1 is identified as a novel CRC target contributing to ESCC viability. Using circular chromosome conformation capture sequencing (4C-seq) and CRISPR/Cas9 genome editing, the direct interaction between TP63 promoter and functional enhancers which is mediated by CRC TFs is identified. Deletion of each enhancer decreases expression of CRC TFs and impairs cell viability, phenocopying the knockdown of each CRC TF. Targeting epigenetic regulation by inhibition of either the BET bromodomain or HDAC disrupts the CRC program and its dependent global epigenetic modification, consequently suppressing ESCC tumor growth. Importantly, combination of both compounds result in synergistic anti-tumor effect. Graphical Abstract HIGHLIGHTS Super-enhancers mediated transcriptional regulatory circuitry is established for ESCC TP63, SOX2 and KLF5 as CRC TFs co-localize super-enhancer loci to orchestrate chromatin accessibility and transcriptional dysregulation Complex interaction between functional enhancers and TP63 promoter is mediated by CRC TFs ALDH3A1 is a key downstream target of ESCC CRC and is essential for ESCC cell survival BET degrader-ARV-771 and HDAC inhibitor-Romidepsin synergistically inhibit ESCC tumor growth