gebhart/patrepeval huggingface dataset:
SARS-CoV-2 Spike Pseudoviruses: A Useful tool to study virus entry and address emerging neutralization escape phenotypes (2021)

Abstract SARS-CoV-2 genetic variants are emerging around the globe. Unfortunately, several SARS-CoV-2 variants, especially, variants of concern (VOC) are less susceptible to neutralization by the convalescent and post-vaccination sera, raising concerns of increased disease transmissibility and severity. Recent data suggests the SARS-CoV-2 neutralizing anti-body levels as a good correlate of vaccine mediated protection. However, currently used BSL3 based virus micro-neutralization (MN) assays are more laborious, time consuming and expensive, underscoring the need for BSL2 based, cost effective neutralization assays against SARS-CoV-2 variants. In light of this unmet need, we have developed a BSL2 pseudovirus based neutralization assay (PBNA) in cells expressing Angiotensin Converting Enzyme-2 (ACE2) receptor for SARS-CoV-2. The assay is reproducible (R 2 =0.96), demonstrates a good dynamic range and high sensitivity. Our data suggests that the biological Anti-SARS-CoV-2 research reagents such as NIBSC 20/130 show lower neutralization against B.1.351 RSA and B1.1.7 UK VOC, whereas a commercially available monoclonal antibody MM43 retains activity against both these variants. SARS-CoV-2 Spike Pseudovirus based neutralization assays for VOC would be useful tools to measure the neutralization ability of candidate vaccines in both preclinical models and clinical trials and further help develop effective prophylactic countermeasures against emerging neutralization escape phenotypes.
Emotion Analysis Using Latent Affective Folding and Embedding (2010)

jerome @ apple.com Though data-driven in nature, emotion analysis based on latent semantic analysis still relies on some measure of expert knowledge in order to isolate the emotional keywords or keysets necessary to the construction of affective categories. This makes it vulnerable to any discrepancy between the ensuing taxonomy of affective states and the underlying domain of discourse. This paper proposes a more general strategy which leverages two distincts semantic levels, one that encapsulates the foundations of the domain considered, and one that specifically accounts for the overall affective fabric of the language. Exposing the emergent relationship between these two levels advantageously informs the emotion classification process. Empirical evidence suggests that this is a promising solution for automatic emotion detection in text. 1
Multi-ten-milli-joule operation of diode-pumped Yb:LiYF/sub 4/ chirped-pulse regenerative amplifier (2003)

A diode-pumped Yb:LiYF4 chirped-pulse regenerative amplifier has been demonstrated. 24 mJ output power was obtained with 10 Hz repetition rate before compression. 53 mJ was numerically estimated with an additional diode pump source.
A predictive robust cascade position-torque control strategy for Pneumatic Artificial Muscles (2010)

Abstract—A robust cascade strategy is proposed and tested on an electropneumatic testbed for parallel robotic applications. It is applied on Pneumatic Artificial Muscles (PAMs). Nonlinear models are developed and presented. By specifying the pressure average between the two muscles, it is possible to control the torque by controlling the pressure in each muscle. A constrained LMI based H ∞ controller is synthesized for the pressure inner loop. A computed torque is applied on the torque loop and a Generalized Predictive Controller (GPC) controller is then applied to control position of the muscles. Experimental results show the feasibility of the control strategy and good performances in terms of robustness and dynamic tracking. Index Terms—GPC, cascade control, pneumatic actuators, modeling, LMI, feedback linearization, robust control, H∞, PAMs.
Supplementary Table 1, Figures 1 - 4 from <i>In Vivo</i> Tomographic Imaging of Deep-Seated Cancer Using Fluorescence Lifetime Contrast (2023)

&lt;p&gt;Supplementary table 1: Table of tissue optical properties used in Monte Carlo simulations. Food autofluorescence: Food autofluorescence can be reduced in the fluorescence images either through specially formulated diet, or using lifetime contrast. Supplementary Figure 1: Fluorescence lifetime contrast between iRFP labelled cancer cells and food autofluorescence. Supplementary Figure 2: Sensitivity for detection of iRFP720 labelled cells subcutaneously placed in a live mouse. Supplementary Figure 3: Lifetime analysis of ex vivo cryosections reveal that iRFP labelled cancer cells i.v. injected in live mice are localized to the lungs. Supplementary Figure 4: CW Fluorescence reflectance images of ex vivo cryosections provide limited contrast for detecting differential extent of experimental metastasis formation in three mice.&lt;/p&gt;
Measuring Performance (2016)

Do your performance measures seek primarily to detect and control undesirable activities, rather than sharing and rewarding productive behaviour? Every organisation needs to measure its performance and that of the people it employs; David Jenkins shows you how to make more productive use of such measures. For measures to be accurate and reliable there are fundamental rules that need to be applied. Ignoring or misapplying them undermines performance and impedes the achievement of the corporate goal. For any enterprise, data must be available across the whole spectrum of activity in which it is engaged. The quality of that information will depend on the way it is measured. In some commercial organisations data is regularly gathered at local level. Instead of being used at this point, it is often fed into a corporate information system which, having recycled it, issues the result in a form that does not always meet needs. In Measuring Performance, David Jenkins examines the more traditional measures of performance and highlights their shortcomings as well as assessing the merits of the alternative approaches that are currently available. The book concludes with a step-by-step guide to reviewing the effectiveness of your organisation's existing systems for measuring performance and identifying ways of improving them.
Lewis Albert Sayre and the Suspension Treatment of Spinal Disease (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Effect of ozone on neutrophil function in vitro (2001)

The application of ozone is widely practised as a form of alternative medicine, particularly in Germany and Eastern Europe. Ozone major autohemotherapy (the return of a small amount of a patient's blood to the circulation after ex vivo exposure to ozone) has been reported to have a therapeutic effect in various pathological conditions, including ischemic, infectious, autoimmune and neoplastic disorders. Ozone has an effect on the expression of cytokines, adhesion molecules and acute phase reactants, which are responsible in part for the respiratory inflammatory response observed after exposure to this gas. The purpose of the present study was to investigate the effect of ozone administration ex vivo, at a concentration commonly used in major autohemotherapy, on peripheral blood neutrophil function in vitro. Blood drawn from healthy volunteers was studied for neutrophil adhesion, chemotaxis and O-2 production before and after exposure to 30 microg/ml ozone. There was no significant difference in adhesion and chemotaxis of neutrophils exposed to ozone versus unexposed cells. O-2 production was minimally decreased (20.3 +/- 5.0 vs. 22.1 +/- 5.5 nmol/106 cells/10 min, respectively; P=0.01), a reduction of no clinical significance. This study confirms that major autohemotherapy with ozone is safe as far as neutrophil function is concerned. Combined with previous data, it seems that well-designed clinical trials to assess the efficacy of major autohemotherapy would pose no danger to blood cell populations, and should be encouraged.
Magic configurations in moiré superlattice of bilayer photonic crystals: Almost-perfect flatbands and unconventional localization (2022)

International audience
Quantification of Active Sites and Elucidation of the Reaction Mechanism of the Electrochemical Nitrogen Reduction Reaction on Vanadium Nitride (2019)

Abstract Despite recent intense interest in the development of catalysts for the electrochemical nitrogen reduction reaction (ENRR), mechanistic understanding and catalyst design principles remain lacking. In this work, we develop a strategy to determine the density of initial and steady‐state active sites on ENRR catalysts that follow the Mars–van Krevelen mechanism via quantitative isotope‐exchange experiments. This method allows the comparison of intrinsic activities of active sites and facilitates the identification and improvement of active‐site structures for ENRR. Combined with detailed density functional theory calculations, we show that the rate‐limiting step in the ENRR is likely the initial N≡N bond activation via the addition of a proton and an electron to the adsorbed N 2 on the N vacancies to form N 2 H. The methodology developed and mechanistic insights gained in this work could guide the rational catalyst design in the ENRR.
The synthesis of spiro[adamantane‐[1,2]dioxetanes] (1982)

Abstract It is shown that the spiroadamantane group stabilizes thermally labile 1,2‐dioxetanes sufficiently to permit isolation. With the help of this stabilizing group it was possible to prepare the first sulfur substituted dioxetanes 9k and 1 and characterize them by low temperature 13 C and 1 NMR spectra. Photosensitized singlet oxygenation at low temperature, using either polymer‐bound Rose Bengal or tetraphenylporphyrin as sensitizer in methylene chloride, of the corresponding 2‐methyleneadamantanes 8 was the method of choice for the preparation of the spiro[adamantane‐[1,2]dioxetanes] 9 , provided that the methylene carbon bears no alkyl or phenyl substituents. The Kopecky method, i.e. hydroperoxybromination of the 2‐methyleneadamantanes 8 and subsequent dehydrobromination, proved unsuccessful to prepare the dioxetanes 9 .
Volatile Water Soluble Constituents of Grapefruit Juice (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolatile Water Soluble Constituents of Grapefruit JuiceJ. G. Kirchner, J. M. Miller, R. G. Rice, G. J. Keller, and M. M. FoxCite this: J. Agric. Food Chem. 1953, 1, 7, 510–512Publication Date (Print):June 1, 1953Publication History Published online1 May 2002Published inissue 1 June 1953https://pubs.acs.org/doi/10.1021/jf60007a004https://doi.org/10.1021/jf60007a004research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CNT Ink Preparation by Combined Use of High-pressure Emulsification and a Low Molecular Weight Organic Electrolyte as a Dispersant (2019)

Homogeneous single-walled carbon nanotube (SWCNT) ink, suitable for film formation in wet processes, was prepared using high-pressure emulsification (HPE) with the addition of an efficient dispersa...
ChemInform Abstract: Palladium Catalyzed Reactions in Industry. Part 2. First Heck Reactions of Aryldiazonium Salts Using Heterogeneous Catalysts. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration (2014)

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this activity is lost. However, whether axon survival is regulated by the supply of NAD or by another action of this enzyme remains unclear. Here we show that the nucleotide precursor of NAD, nicotinamide mononucleotide (NMN), accumulates after nerve injury and promotes axon degeneration. Inhibitors of NMN-synthesising enzyme NAMPT confer robust morphological and functional protection of injured axons and synapses despite lowering NAD. Exogenous NMN abolishes this protection, suggesting that NMN accumulation within axons after NMNAT2 degradation could promote degeneration. Ectopic expression of NMN deamidase, a bacterial NMN-scavenging enzyme, prolongs survival of injured axons, providing genetic evidence to support such a mechanism. NMN rises prior to degeneration and both the NAMPT inhibitor FK866 and the axon protective protein Wld(S) prevent this rise. These data indicate that the mechanism by which NMNAT and the related Wld(S) protein promote axon survival is by limiting NMN accumulation. They indicate a novel physiological function for NMN in mammals and reveal an unexpected link between new strategies for cancer chemotherapy and the treatment of axonopathies.
Structure–activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines (2011)

Human epidermal growth factor receptor 2 (HER2) is a member of the human epidermal growth factor receptor kinases and is involved in a signaling cascade for cell growth and differentiation. It is well established that HER2-mediated heterodimerization has important implications in cancer. Deregulation of signaling pathways and overexpression of HER2 is known to occur in cancer cells, indicating the role of HER2 in tumorigenesis. Therefore, blocking HER2-mediated signaling has potential therapeutic value. We have designed several peptidomimetics to inhibit HER2-mediated signaling for cell growth. One of the compounds (compound 5, Arg-[3-amino-3(1-napthyl)-propionic acid]-Phe) exhibited antiproliferative activity with IC(50) values in the nanomolar to micromolar range in breast cancer cell lines. To further investigate the structure-activity relationship of the compounds, various analogs of compound 5 were designed. Conformational constraints were initiated in the peptidomimetic with introduction of a Pro residue in the peptidomimetic sequence. Results of antiproliferative activity indicated that analogs of compound 5 with C-and N-terminal ends capped (compound 16) and compound 9 with Asp at the C-terminal exhibited antiproliferative activity in the lower micromolar range against breast cancer cell lines. Introduction of conformational constraints such as Pro residue in the sequence or cyclization did not enhance the activity of the peptidomimetic. Competitive binding studies were carried out to evaluate the binding of potent peptidomimetics to HER2-overexpressing cancer cell lines. Results indicated that compounds exhibiting antiproliferative activity in breast cancer cell lines bind to the cells that overexpress HER2 protein.
Cadmium in human population (1986)

Due to man’s activity, trace metals are slowly being redistributed in the environment. During the last decades, concentrated metal deposits that are confined in the earth’s crust and which are usually harmless to living beings, have been exploited at an increasing rate and discharged partly in the environment. Among these metals, cadmium has raised the most concern because of its high toxicity coupled with an exceptional tendency to accumulate in the human organism.
Effect of hip braces on brake response time (2016)

Based on our findings, it does not seem mandatory to recommend driving abstinence for patients wearing a hip orthosis. We suggest that our results be interpreted with caution, because (1) an underlying pathological hip condition needs to be considered, (2) the ability to drive a car safely is multifactorial and brake response time is only one component thereof and (3) brake response time measurements were performed only with healthy participants. Clinical relevance Hip braces are used in the context of joint-preserving and prosthetic surgery of the hip. Therefore, clinicians are confronted with the question whether to allow driving a car with the respective hip brace or not. Our data suggest that hip braces do not impair brake response time.
Aerosol penetration through a model transport system: comparison of theory and experiment (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAerosol penetration through a model transport system: comparison of theory and experimentAndrew R. McFarland, Fermin S. Wong, N. K. Anand, and Carlos A. OrtizCite this: Environ. Sci. Technol. 1991, 25, 9, 1573–1577Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/es00021a007https://doi.org/10.1021/es00021a007research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermoelectric Characterization and Power Generation Using a Silicon-on-Insulator Substrate (2011)

We demonstrate techniques for measuring thermoelectric voltages and generating on-chip power using a silicon-on-insulator substrate. Our design uses lateral heat conduction in the silicon overlayer to establish temperature gradients, which dramatically reduces microfabrication complexity compared to competing designs based on a free-standing membrane. This letter characterizes the thermoelectric power of a metal–semiconductor structure involving a doped SbTe alloy that is relevant for phase-change memory. The thermoelectric power of the SbTe–TiW thermocouple is 24 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{V/K}$</tex></formula> , and the power generation output achieves up to 0.56 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{W/cm}^{2}$</tex></formula> with a temperature gradient of 18 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}\hbox{K}$</tex></formula> . <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hfill$</tex></formula> [2011-0233]
Error Control of Multiple-Precision MLFMA (2018)

We introduce and demonstrate a new error control scheme for the computation of far-zone interactions in the multilevel fast multipole algorithm when implemented within a multiple-precision arithmetic framework. The proposed scheme provides the optimum truncation numbers as well as the machine precisions given the desired relative error thresholds and the box sizes for the translation operator at all frequencies. In other words, unlike the previous error control schemes which are valid only for high-frequency problems, the proposed scheme can be used to control the error across both low- and high-frequency problems. Optimum truncation numbers and machine precisions are calculated for a wide range of box sizes and desired relative error thresholds with the proposed error control scheme. The results are compared with the previously available methods and numerical surveys.
Applications of wavelength dispersion in 1D and 2D photonic crystals (2005)

One of the most distinctive features of photonic crystals (PhCs) is their unique wavelength dispersion allowing novel device concepts for enhancement of photonic functionality and performance. Here, we present examples of our design and demonstrations utilizing dispersion properties of 1D and 2D photonic crystals. This includes the demonstration of negative refraction in 2D PhC at optical wavelengths, filters based on 1D and 2D PhC waveguides, and the design of a widely tunable filter involving 1D PhC.