gebhart/patrepeval huggingface dataset:
Expresiones explícitas de los autovectores ortonormalizados para materiales transversalmente isótropos en el formalismo de Stroh. Aplicación al análisis de singularidades en uniones adhesivas (2003)

La resolución de problemas de elasticidad lineal anisótropa, utilizando el formalismo de&#13;\nStroh, se basa en el conocimiento de los autovalores y autovectores de la matriz de&#13;\nelasticidad fundamental N. En el presente trabajo se presenta el conjunto completo de&#13;\nexpresiones explícitas de dichos autovalores y autovectores para materiales&#13;\ntransversalmente isótropos. Puesto que el comportamiento de las láminas unidireccionales&#13;\nde materiales compuestos fibrosos es típicamente transversalmente isótropo, los resultados&#13;\nobtenidos permiten el análisis de problemas con este tipo de materiales. Se presentan&#13;\naplicaciones para uniones adhesivas entre metales y materiales compuestos.
Transform methods of PAM signals for asymmetric distribution in 3rd-order blind equalizer (2002)

In this paper, we have considered the 3rd order blind equalizer using symmetric to asymmetric transforms and asymmetric to symmetric transforms of PAM signals by the square root operation and reciprocal operation. The purposes of these transforms and 3rd order blind equalizations are (i) better mean square error (MSE) performances with less computational complexities than 4th order blind equalizers and (ii) real time operations are required for estimating 3rd order cumulants. At the receiver square operation and reciprocal observation are required for recovering the asymmetrically transformed signals after equalization. As a result of computer simulation, transform methods with reciprocal and square root operations are better than the transform method with the natural logarithmic operation by about 8 dB maximum in MSE at specific K, compression factor. The computational complexities of the 3rd order method are about a half that of the 4th order method. We discuss the importance of skewness at small values and the performance of the blind equalizer.
Design of microcavity resonators for single-atom detection (2007)

Whispering gallery modes of a microdisk resonator are useful for the optical detection of single rubidium and cesium atoms near the surface of a substrate. Light is coupled into two high-Q whispering-gallery modes of the disk which can provide attractive and/or repulsive potentials, respectively, via their evanescent fields. The sum potential, including van der Waals/Casimir-Polder surface forces, may be tuned to exhibit a minimum at distances on the order of 100 nm from the disk surface. Simultaneously optically trapping and detecting is possible, with the back-action of an atom held in this trap on the light fields being suffciently strong to provide a measurable effect. Atom trapping and detection depend on a variety of system parameters and experimental realizations differ for different atoms.
Modeling altered germinal center responses due to oncogenic activating mutations in CARMA1 (2016)

Abstract BCR engagement drives phosphorylation of the multi-adapter, CARMA1, and assembly of signaling complexes required for NF-κB activation. B cell lymphomas are frequently associated with constitutive NF-κB activation that sustains their survival. At least 10% of germinal center (GC) derived, activated B-cell like diffuse large B-cell lymphomas (ABC-DLBCLs) exhibit gain-of-function mutations in CARMA1. In the current study, we directly assess the impact activated CARMA1 (aCARMA1) on GC biology. We developed a novel mouse model that permits inducible expression of aCARMA1. Following T-dependent immunization, mice with B cell intrinsic aCARMA1 exhibit an expanded plasma cell compartment and reduced GC B cell numbers. A similar phenotype was present with GC restricted aCARMA1 expression, leading to increased total and antigen-specific IgG. ABC-DLBCL tumors frequently exhibit somatic mutations predicted to block terminal B cell differentiation. To better define how aCARMA1 impacts GC biology and cooperates with these lesions, we crossed KI mice to Blimp1F/F mice. aCARMA1 expression, in the absence of Blimp1, lead to increased GC B cell numbers compared to controls. Current studies are focused on detailed analysis of this altered response. Our results demonstrate that aCARMA1 is sufficient to alter the GC response and B cell fate, favoring plasma cell development. Further, in the setting of inability to exit the GC, aCARMA1 may be sufficient to directly promote lymphomagenesis.
Prognosis of unrecognized coeliac disease as regards mortality: A population-based cohort study (2009)

The prognosis of unrecognized coeliac disease was good as regards overall mortality, which does not support screening of asymptomatic coeliac disease cases.
Male Pattern Baldness and Hair Growth Promoters (1995)

This article reviews about hair growth and its cycle, male pattern baldness and its cause, hair growth promoters, and the evaluation methods for such promoters. The mechanism of hair growth and causes of male pattern baldness are still not clear, but recent studies on hair growth are bringing up some interesting and important facts. New discoveries on energy metabolism, interaction between hair matrix and dermal papilla, and action of androgens are discussed along with their application to the production of new hair growth promoters. A new hair growth promoter, monopentadecanoylglycerol (PDG), is discussed in relation to its effect for promating the energy metabolism.
Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series (2021)

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer's disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.
Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature (2012)

We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRPM8 channels, including those on primary sensory neurons. In vivo, M8-B decreased deep body temperature (T(b)) in Trpm8(+/+) mice and rats, but not in Trpm8(-/-) mice, thus suggesting an on-target action. Intravenous administration of M8-B was more effective in decreasing T(b) in rats than intrathecal or intracerebroventricular administration, indicating a peripheral action. M8-B attenuated cold-induced c-Fos expression in the lateral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathway to thermoeffectors, presumably on sensory neurons. A low intravenous dose of M8-B did not affect T(b) at either a constantly high or a constantly low ambient temperature (T(a)), but the same dose readily decreased T(b) if rats were kept at a high T(a) during the M8-B infusion and transferred to a low T(a) immediately thereafter. These data suggest that both a successful delivery of M8-B to the skin (high cutaneous perfusion) and the activation of cutaneous TRPM8 channels (by cold) are required for the hypothermic action of M8-B. At tail-skin temperatures <23°C, the magnitude of the M8-B-induced decrease in T(b) was inversely related to skin temperature, thus suggesting that M8-B blocks thermal (cold) activation of TRPM8. M8-B affected all thermoeffectors studied (thermopreferendum, tail-skin vasoconstriction, and brown fat thermogenesis), thus suggesting that TRPM8 is a universal cold receptor in the thermoregulation system.
Transcatheter Myotomy to Treat Hypertrophic Cardiomyopathy and Enable Transcatheter Mitral Valve Replacement: First-in-Human Report of Septal Scoring Along the Midline Endocardium (2022)

ventricular remodeling
Changes in immune and psychological measures as a function of anticipation and reaction to news of HIV-1 antibody status. (1990)

We assessed changes in psychological and immunological functioning during 5-week periods preceding and following notification of serostatus among gay males taking the HIV-1 antibody test. Forty-six asymptomatic homosexual men between the ages of 18 and 40 yrs were recruited from a gay men's organization and through advertisements in a local newspaper. Measures of cell-mediated immunity (lymphocyte phenotypic markers, mitogen responsivity, and natural killer cell cytotoxicity) and psychological functioning (state anxiety, intrusive thoughts, and avoidant behaviors) were obtained at baseline, five weeks later and 72 hr before serostatus notification, and 1 week, 3 weeks and 5 weeks postnotification. Results suggested a dissociation between psychological and immunological phenomena among seropositives wherein lymphocyte proliferative responses to the mitogens phytohemagglutinin (PHA) and pokeweed mitogen (PWM) remained unchanged in the face of significant increases in state anxiety and intrusive thoughts following serostatus notification. These findings suggested that asymptomatic HIV-1 infected individuals, even at the earliest stages of infection, may be unable to mount an immune response to potent psychosocial stressors (i.e., serostatus notification), due perhaps, to the fact that the viral contribution to immune functioning overrides any influence of environmental stimuli. Among the seronegative subjects studied, blastogenic responses to PHA and PWM were depressed at baseline (relative to a group of age and gender-matched controls who were not undergoing HIV-1 antibody testing) but PHA values returned to normal values 5 weeks later. Natural killer (NK) cell cytotoxicity and CD4+CD45R+ inducer cell counts appeared to parallel these changes in seronegatives. Seropositives did display fluctuations in NK cell cytotoxicity that were similar to those noted for seronegatives. Correlational analyses suggested that individual differences in anxiety responses at the time of notification of seropositivity predicted subsequent (1-week lag) declines in NK cell cytotoxicity but not other functional markers. Although most seropositives displayed clinical levels of anxiety, intrusive thoughts and avoidant responses during the week of serostatus notification, these measures returned to their initial nonclinical baseline levels within 5 weeks after notification in both the seropositive and seronegative groups.
Intersecting Sets: a Basic Abstraction for Asynchronous Agreement Problems (2006)

Defining good abstractions is a central issue when one wants to understand the deep structure and basic principles that underlie computing mechanisms. This paper introduces a basic and particularly simple distributed computing abstraction suited to asynchronous distributed agreement problems. This abstraction, called intersecting sets, requires each process to deposit a value and allows each non-faulty process to obtain a subset of these values such that any two such sets have a non-empty intersection. This simple abstraction captures an essential part of distributed agreement problems. After having introduced and motivated this abstraction, the paper investigates its properties, its power and its benefit when solving distributed agreement problems.
Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin (2008)

Thiazolidinediones are ligands of PPAR-gamma, a member of the nuclear receptor family. These drugs have shown promising pre-clinical activity in tumor models but clinical studies failed to confirm their beneficial effect. We have studied the in vitro antitumor effects of a combination of ciglitazone, a thiazolidinedione drug, and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. We observed a marked synergism in several different tumor cell lines resulting from both inhibition of cell proliferation and induction of apoptosis. These results strongly suggest that combining PPAR-gamma agonists with statins can produce significant antitumor effects.
Evaluation of three PCR-based diagnostic assays for detecting mixed Plasmodium infection (2010)

The nested PCR method remains the method of choice for the detection of mixed malaria infections and especially of sub-clinical infections. Further optimization and/or new molecular gene targets may improve the success rate of detecting multiple parasite species simultaneously using traditional PCR assays.
Accuracy of differential expression detection with compressed microarray images (2006)

Current gene-expression microarrays carry an enormous amount of information. This paper examines lossy SPIHT and JPEG 2000 compression of oligo microarray images and addresses the accuracy of differential expression detection with compressed images. Experiments show that the identification disagreement rate for all genes monotonically increases with the compression ratio, but is still under 1.5% at 20:1 compression with both SPIHT and JPEG 2000.
SynaptomeDB: an ontology-based knowledgebase for synaptic genes (2012)

We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
Synthesis and Structure of a Hypercoordinate Silicon-Bridged [1]Ferrocenophane (2000)

The first hypercoordinate silicon-bridged [1]ferrocenophane shows a pronounced Si−N interaction, a pseudo-trigonal-bipyramidal geometry at the bridging silicon atom, an elongated Si−Cp bond trans to the amino group, and an unusually long Fe−Si distance in comparison to the tetracoordinate analogues.
LCH of the Scapula in a 2-Year-Old Masquerading as an ABC: A Case Report and Literature Review (2020)

We describe a unique case of Langerhans Cell Histiocytosis (LCH) arising in the scapula of a 2-year old male child masquerading as an aneurysmal bone cyst (ABC) at clinical presentation and on imaging. Scapular involvement is only occasionally noted in LCH cases. Solitary bone involvement in our patient’s age group is uncommon in LCH without multi-organ involvement. Careful pathologic examination and immunohistochemistry was crucial in establishing this diagnosis due to the presence of a solitary lesion with fluid-fluid levels.
Physicochemical Characterization of Morpholinium Cation Based Protic Ionic Liquids Used As Electrolytes (2010)

New protic ionic liquids (PILs) based on the morpholinium, N-methylmorpholinium, and N-ethyl morpholinium cations have been synthesized through a simple and atom-economic neutralization reaction between N-alkyl morpholine and formic acid. Their densities, refractive indices, thermal properties, and electrochemical windows have been measured. The temperature dependence of their dynamic viscosity and ionic conductivity have also been determined. The results allow us to classify them according to a classical Walden diagram and to evaluate their "fragility". In addition, morpholinium based PILs exhibit a large electrochemical window as compared to other protic ionic liquids (up 2.91 V) and possess relatively high ionic conductivities of 10-16.8 mS x cm(-1) at 25 degrees C and 21-29 mS x cm(-1) at 100 degrees C, and a residual conductivity close to 1.0 mS x cm(-1) at -15 degrees C. PIL-water mixtures exhibit high ionic conductivities up to 65 mS x cm(-1) at 25 degrees C and 120 mS x cm(-1) at 100 degrees C for morpholinium formate with water weight fraction w(w) = 0.6. Morpholinium based PILs studied in this work have a low cost and low toxicity, are good ionic liquids, and prove extremely fragile. They have wide applicable perspectives as electrolytes for fuel cell devices, thermal transfer fluids, and acid-catalyzed reaction media as replacements of conventional solvents.
Microcarrier culture of bowes melanoma cells in serum‐free medium with Human plasma fraction IV‐4+ V (1991)

Bowes melanoma cells were cultivated successfully in a serum-free medium which was constructed by the concept of maximum retention of proteins from fractionated human plasma having growth stimulatory activities. The cells could be cultivated in the serum-free medium without any adaptation period. The major serum-free component of the medium was the fraction IV-4 + V of the Cohn fractionation process of human plasma. Approximately six times increase of tissue-type plasminogen activator (t-PA) activity as compared with that in serum-free medium even though the cell growth was much slower. In addition, the growth stimulatory activities of thrombin and fibronectin were investigated during the cultivation of Bowes melanoma cells in this serum-free medium. These proteins contributed significantly to the enhanced growth of cells by reducing doubling time to 25 and 35 h as compared with 55 h in the serum-free medium without them. Especially, fibronectin supported cells to propagate near to the maximum cell density achieved in the medium with 10% FBS.
CAFIIR: An image based CBR/IR application (1993)

In this paper we describe a multimedia application called Computer Aided Facial Image Inferencing and Retrieval (CAFIIR) system. This system uses both Case Based Reasoning and Information Retrieval Techniques. In CAFIIR we use fuzzy measures to represent characteristic features of a human face. This paper describes a method designed to implement inferencing using fuzzy measures. It also describes how CAFIIR handles CHFs values that may span across two or more Fuzzy sets. The paper illustrates how Dempster Sharer theory can be useful for extracting weights for individual characteristic features when weights are given for combined features. Some parts of the application have been implemented while others are still under implementation.
Isolated Perfused Rat Liver: An Experimental Model for Studies on Ammonium and Amino Acid Metabolism (1987)

Isolated perfused rat liver is a well-established experimental model for studies on hepatic amino acid and ammonia metabolism. Some aspects and modifications of the liver-perfusion technique are discussed. Perfusion studies with the intact liver have the fundamental advantage that the structural and functional organization of the liver is preserved; however, the experimental system is more complex in view of subcellular and intercellular compartmentation and the recently demonstrated metabolic interactions of different cell populations at the acinar level. These problems of complexity by compartmentation can be largely solved by introducing further techniques such as organ spectrophotometry, the retrograde/antegrade perfusion technique, use of micro-oxygen-electrodes, use of selective inhibitors, radiolabeled compounds, different fractionation techniques of the liver tissue. By means of these approaches, intracellular events can be followed up not only indirectly by analyzing the composition of the perfusate before and after a liver passage, but also directly in the different subcellular and subacinar compartments of a structurally and metabolically intact liver.
Method of making a rocket motor casing Patent (1966)

Method for shaping regeneratively cooled rocket motor casing having minimum thickness at each channel cross section
A comparison of the NCT Reichert R7 with Goldmann applanation tonometry and the Reichert ocular response analyzer (2011)

The new NCT, R7 overestimated the IOP compared with GAT in normal, healthy eyes by about 1.7 mmHg on average (95% confidence range of approximately -2 to +6 mmHg). The measures provided by the R7 were significantly influenced by the stiffness of the corneal tissue as measured by the ORA CRF value but not by other dimensional parameters of the eye.
On the Nature of Stall (1959)

The physical data available on the problem of stall are reviewed. The discussion is centered on the problem of flow in passages. The emphasis is placed on systematic visual data showing flow patterns as a function of geometrical parameters. These data lead to a view of stall as a spectrum including three or possibly four major types of flow patterns; these patterns involve both transient and steady elements. A qualitative parameter is formulated which provides a classification for the major types of stall. It is shown that this parameter and its underlying concepts are useful in rationalizing known but previously inexplicable results and in obtaining important qualitative predictions. Comparisons between the predictions of boundary-layer theory and the actual systematic stall data of passages are given.
Precision micro cutting of thin steel plate with newly designed laval nozzle by pulsed YAG laser (2004)

This paper deals with laser cutting of thin steel plate by pulsed YAG laser using newly designed Laval nozzle. The assist gas flow spouted from the Laval nozzle dose not have Mach Shock Disk in free jet, and its straightness is superior to a traditional convergent nozzle. Therefore, the pressure on workpiece increases, and the dross height can be reduced remarkably even under low supply gas pressure condition. Thus, the consumption of flow quantity of assist gas can be reduced, when the dross height is equal. Besides, color change by excessive oxidation due to the heat conduction from dross is smaller at the back side of workpiece around the kerf, since Laval nozzle can remove melted material more effectively compared to a convergent nozzle. However, the supplied gas pressure should be carefully set, since Laval nozzle has many unstable regions, where the pressure on workpiece changes periodically. The dross height dose not increase or almost equal in the case of Laval nozzle, when the gap distance between the nozzle tip and the workpiece surface is changed from 1mm to 2mm. Because the assist gas flow from Laval nozzle has an excellent straightness and the pressure on workpiece does not reduce drastically. Moreover, it was made clear that Laval nozzle designed for the special condition can reduce the dross more effectively and decrease the unstable region.
Equilibria in complexes of N-heterocyclic molecules. Part 34. Iron binding by caerulomycins (1984)

Spectroscopic properties of caerulomycin (Hcmn) complexes with iron(II) are discussed. The stoicheiometry of complexation (Job's method) is 2 cmn : 1 Fe; cmn acts as a terdentate ligand. The pKa for the red [Fe( Hcmna)(cmna)]+(Hcmna = caerulomycin A) to form its purple conjugate base [Fe(cmna)2] is 3.5. Solid compounds were made containing both the red cation and the purple uncharged species. Visible c.d. spectra are reported for caerulomycin D and its iron(II) complex.