gebhart/patrepeval huggingface dataset:
Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28. (1996)

The hereditary form of incontinentia pigmenti (IP2) is a rare disorder characterized by abnormalities of the tissues and organs derived from the ectoderm and neuroectoderm and has been linked to Xq28 distal to the factor VIII gene (F8C). Four YAC clones covering the 1.1-Mb candidate region at the telomere of Xq28 were subjected to direct cDNA selection and Alu long-range PCR. The products of both methods were subsequently used to isolate 154 cosmid clones that were assembled into five cosmid contigs. This first-generation cosmid map covered the region almost entirely and was used as a basis for constructing a transcript map that was in turn integrated with the physical YAC and cosmid maps. To isolate specifically coding sequences, exon trapping and cDNA selection methods were combined. Exon trapping was carried out on YAC Alu-PCR products, YAC Alu long-range PCR products, and on pools of cosmids. The region-specific enriched cDNA library was then screened by using the exon trap products as complex probes. To ensure a more complete analysis, the products from cDNA selection experiments were also used to screen conventional oligo(dT) primed cDNA libraries. Twenty overlapping cDNA contigs were assembled and computer analyses were performed to identify EST hits, open reading frames, protein motifs, and protein sequence homologies. Five of the cDNA contigs corresponded to known sequences such as the factor VIII, c6.1A, and c6.1B. genes, and both distal copies of the factor VIII intron 22 repeat sequence. Expression patterns of the 15 new cDNA contigs were analyzed by Northern blot and RT-PCR studies and these data were integrated with expression data obtained from known EST sequences. Although a more detailed analysis of this 1.1-Mb region with respect to the structure and function of the genes will only ultimately be possible by a global sequencing approach, an analysis of all novel transcripts as candidate genes for incontinentia pigmenti is already in progress.
Predilection of contralateral upper lung metastasis in upper lobe lung adenocarcinoma patients. (2016)

Upper lobe lung adenocarcinoma was significantly associated with contralateral upper lung predominance metastases. Further research is needed to elucidate the mechanisms underlying this phenomenon.
Measurement of the Heme Affinity for Yeast Dap1p, and Its Importance in Cellular Function (2007)

Current studies on the Saccharomyces cerevisiae protein Dap1p have demonstrated a heme-related function within the ergosterol biosynthetic pathway. Here we present data to further the understanding of the role of heme in the proper biological functioning of Dap1p in cellular processes. First, we examined the role of Dap1p in stabilizing the P450 enzyme, Erg11p, a key regulatory protein in ergosterol biosynthesis. Our data indicate that the absence of Dap1p does not affect Erg11p mRNA, protein expression levels, or the protein degradation rates in S. Cerevisaie. Second, in order to probe the role of heme in the biological functioning of Dap1p, we measured ferric and ferrous heme binding affinities for Dap1p and the mutant Dap1pY138F, as well as equilibrium midpoint reduction potentials of the Fe(III)/Fe(II) couples. Our results show that both wild-type and mutant proteins bind heme in a 1:1 fashion, possessing tight ferric heme affinities, KD values of 400 pM and 200 nM, respectively, but exhibiting weak ferrous affinities, 2 and 10 microM, respectively. Additionally, the measured reduction potential of Dap1p, which was found to be -307 mV, is similar to that of other monotyrosinate hemoproteins. Although previous reports show the weaker affinity of Dap1pY138F for ferric heme lowers the production of ergosterol with respect to wild-type Dap1p in S. pombe, we find that Dap1pY138F expression is still sufficient to rescue the growth sensitivity of dap1Delta to fluconazole and methyl methanesulfonate in S. cerevisiae. Various interpretations of these results are discussed with respect to Dap1p function in the cell.
Acc/aha/esc guidelines for the management of patients with atrialfibrillation: executive summary a report of the american college ofcardiology/american heart association task force on practice guideli (2001)

Acc/aha/esc guidelines for the management of patients with atrialfibrillation: executive summary a report of the american college ofcardiology/american heart association task force on practice guideli
Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis (2001)

The antimicrobial activity of honokiol and magnolol, the main constituents of Magnolia officinalis was investigated. The antimicrobial activity was assayed by the agar dilution method using brain heart infusion medium and the minimum inhibitory concentration (MIC) were determined for each compound using a twofold serial dilution assay. The results showed that honokiol and magnolol have a marked antimicrobial effect (MIC = 25 microg/mL) against Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Micrococcus luteus and Bacillus subtilis, but did not show antimicrobial activity (MIC > or = 100 microg/mL) for Shigella flexneii, Staphylococcus epidermidis, Enterobacter aerogenes, Proteus vulgaris, Escherichia coli and Pseudomonas aeruginosa. Our results indicate that honokiol and magnolol, although less potent than tetracycline, show a significant antimicrobial activity for periodontal pathogens. Hence we suggest that honokiol and magnolol might have the potential to be an adjunct in the treatment of periodontitis.
Fruits, vegetables and their polyphenols protect dietary lipids from oxidation during gastric digestion (2014)

Previous studies indicate that the ingestion of oxidized vegetable oils leads to the incorporation of chemically reactive molecules issued from the decomposition of the initial lipid hydroperoxides into lipoproteins. The aim of the present study is to investigate the oxidation of dietary lipids in the gastric compartment and their inhibition by plant polyphenols provided either as fruit and vegetables (F&V) or an extract. Six minipigs received a standard Western diet containing primarily sunflower oil, ground beef meat, and starch. Polyphenols in different matrix forms were ingested either as cubed F&V or as the corresponding hydroacetonic extract. Sampling of the gastric digesta allowed the kinetic investigation of pH, heme and non-heme iron forms, total lipids, lipid-derived conjugated dienes (CD) and TBARS. F&V and the corresponding polyphenol extract delayed the gastric digestion process as shown for total lipid and heme iron contents. This study also demonstrated the occurrence of in vivo oxidation of dietary lipids in the presence of meat iron. Interestingly, F&V played a protective role by totally inhibiting the accumulation of CD while largely decreasing the formation of TBARS. The polyphenol extract similarly slowed down the TBARS formation although it had no effect on the CD accumulation.
Online signature verification system with anti-forgery provision based on segmentation and structure learning of HMM (2010)

Inspired by forensic experts working on authentication of oriental characters like Chinese and Japanese who usually rely on distinguishing detailed features of individual strokes such as dots and straight lines, our new HMM model consisted of many sub-models each represents an individual stroke of a signature. Furthermore, 3 models were compared in 2 steps using a hierarchical manner. First, original user was distinguished from data corpus consisted of random forgeries; Secondly, original user was distinguished from skilled forgeries.
RobotCore: An Open Architecture for Hardware Acceleration in ROS 2 (2022)

Hardware acceleration can revolutionize robotics, enabling new applications by speeding up robot response times while remaining power-efficient. However, the diversity of acceleration options makes it difficult for roboticists to easily deploy accelerated systems without expertise in each specific hardware platform. In this work, we address this challenge with RobotCore, an architecture to integrate hardware acceleration in the widely-used ROS 2 robotics software framework. This architecture is target-agnostic (supports edge, workstation, data center, or cloud targets) and accelerator-agnostic (supports both FPGAs and GPUs). It builds on top of the common ROS 2 build system and tools and is easily portable across different research and commercial solutions through a new firmware layer. We also leverage the Linux Tracing Toolkit next generation (LTTng) for low-overhead real-time tracing and benchmarking. To demonstrate the acceleration enabled by this architecture, we use it to deploy a ROS 2 perception computational graph on a CPU and FPGA. We employ our integrated tracing and benchmarking to analyze bottlenecks, uncovering insights that guide us to improve FPGA communication efficiency. In particular, we design an intra-FPGA ROS 2 node communication queue to enable faster data flows, and use it in conjunction with FPGA-accelerated nodes to achieve a 24.42% speedup over a CPU.
Tandem Spinning (1995)

A new concept of tandem spinning to produce true, all-staple, core-wrap yarn at high speeds was first disclosed in a paper that reported the results of an initial feasibility study. That study successfully demonstrated the viability of tandem spinning, although it did so by using separate elements of air-jet and friction spinning technologies in a "phased" or sequential manner. Continued research has resulted in the development of a totally integrated tandem spinning system, which produces a unique, all-staple, core-wrap, composite yarn continuously and without interruption. The resulting tan dem spun yarn is torque-balanced, soft, yet strong. The production speed is at least ten times greater than conventional ring spinning and twice as fast as the phased or sequential tandem spinning reported earlier. Yarn counts up to 30 tex (Ne 20's) have been successfully spun on a prototype machine in a textile pilot plant. The resulting yarn quality is satisfactory for downstream processes, including weaving. Preliminary studies indicate that the properties of fabrics made with the unique tandem spun, core-wrap yarns are also satisfactory. Significant commercial potential is envisioned for the new spinning system. Large-scale spinning and weaving trials are currently underway for commercial evaluation. Patent applications have been filed to protect the invention domestically and internationally.
Supplementary Figure 2 from Novel Mechanism of Tumor Suppression by Polarity Gene <i>Discs Large 1</i> (<i>DLG1</i>) Revealed in a Murine Model of Pediatric B-ALL (2023)

&lt;p&gt;PDF file - 76K, Supplemental Figure 2: Conditional deletion of Dlg1 results in a developmental "bottleneck" at the C/C' stage of B cell differentiation.&lt;/p&gt;
Treatment with IGF-I Peptides Improves Function of the Remnant Gut Following Small Bowel Resection in Rats (1994)

The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins. Administration of 278 micrograms/day IGF-I, LR3IGF-I or des(1-3)IGF-I following 70% jejuno-ileal resection significantly attenuated malabsorption of fat and nitrogen. Responses in rats with 80% resection were less substantial, but a dose-responsive reduction in malabsorption was apparent with LR3IGF-I. Both IGF-I and LR3IGF-I were shown to increase body weight gain and food conversion efficiency in a dose-dependent manner following 80% jejuno-ileal resection. Total gut weight was increased by up to 21%, due predominantly to increased weight of the stomach and proximal small bowel, with the latter effect attributable at least in part to an increased bowel length. LR3IGF-I was more potent than IGF-I at stimulating body weight gain and food conversion efficiency, but its potency advantage on gut absorptive function and small intestinal re-growth was less marked. We conclude that administration of IGF-I peptides improves gastro-intestinal absorptive function following partial gut resection, most likely reflecting, at least in part, an increase in gut absorptive surface area.
An Overview on Litchi Fruit Quality and Alternative Postharvest Treatments to Replace Sulfur Dioxide Fumigation (2010)

Abstract Litchi fruit quality is determined by chemical parameters, color, fruit composition (vitamins and minerals) and aroma volatiles. Globally there are growing concerns regarding the use of "sulfiting" agents in fresh fruits and vegetables. Consequently, new restrictive U.S. Food and Drug Administration regulations require its declaration. Sulfur dioxide (SO2), used as a fumigant for litchi, has been officially defined as a pesticide. Detectable levels must be ≤ 10 ppm as specified by the EU. Although an alternative sulfiting agent, Na2S2O5 impregnated pads, showed promising control of decay and color retention, its usage is sometimes limited since the active concentration depends on the type of cultivar. This review summarises the developments in finding appropriate alternative technologies to replace SO2 fumigation. Keywords: litchi fruitpericarp browningpostharvest decaypostharvest technology Acknowledgements This review was partly supported by a grant from the South African Litchi Growers' Association (SALGA) and the Technology and Human Resources for Industry Program (THRIP), a partnership program funded by the Department of Trade and Industry (DTI) and managed by the National Research Foundation (NRF).
Heart of Wetness: Living, narrating, and representing ancient memories and new water rhythms in the Venetian Lagoon (2021)

The natural and human ensemble of Venice and its lagoon, with its peculiar island features, is among one of the most studied urban and environmental systems in the world. This introduction to Shima’s special issue on Venice and its lagoon provides a brief historical and environmental context to this space and a possible platform whereby the local complexity and liminality of wetlands, lagoons and islands gesture to and evoke global themes, conceptual views, and transdisciplinary opportunities. Focusing on key topics like the theatricality of water engineering, the understanding of water rhythms and the recovery of water memories, we introduce the articles presented herein, providing a geo-historical framework for the various interpretations of living, narrating and representing Venice and its lagoon.
A 2- to 16-Year Clinical Follow-Up of Revision Total Hip Arthroplasty Using a New Acetabular Implant Combined With Impacted Bone Allografts and a Cemented Cup (2017)

IBG combined with the compressing shell results in excellent results for this challenging condition.
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments (2007)

Although both SAT and VAT are correlated with metabolic risk factors, VAT remains more strongly associated with an adverse metabolic risk profile even after accounting for standard anthropometric indexes. Our findings are consistent with the hypothesized role of visceral fat as a unique, pathogenic fat depot. Measurement of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.
Impact of firm specific and macroeconomic variables on firm growth: Evidence from Nepal (2017)

This paper examines the impact of firm specific and macroeconomic variables on firm growth using panel data analysis of 333 observations from 37 firms for the period of 2003/04 to 2011/12. Sales growth and assets growth are selected as the indicator of firm growth. The result shows that there is a significant negative impact of firm age on sales growth. The result further confirms thatassets growth in the Nepali firm is positively and significantly affected by shareholders ’equity, leverage, firm size and liquidity whereas, negatively affected by firm age and cash flow. Among the macroeconomic variables, GDP growth and money supply have the significant positive impact on sales growth. However, real interest rate has the significant negative impact on sales growth of the firm. Regarding the assets growth, the variable inflation has significant positive impact and real interest rate has significant negative impact on assets growth in the Nepali firms. Moreover, Lang, Ofck and Stulz (1996) have examined the relationship between leverage and growth and concluded that the strong negative relationship and further confirmed that higher leverage increases the threat of bankruptcy and hence forces managers to improve efficiency. All the contradictory debates create an issue on how the traditional firm specific characteristics affect on firm growth in the underdeveloped and unstructured economy like Nepal. The overall research methodology used in the study. Similarly, section three deals with the results. Finally, section four presents summary, discussions, implications and critiquing of the study.
Growth and subculture of pathogenic T. pallidum (Nichols strain) in BHK-21 cultured tissue cells. (1976)

The growth and nine subcultivations of the experimental Nichols strain of pathogenic Treponema pallidum were successfully accomplished in cultured baby hamster kidney tissue cells (BHK-21) using serum-free media. The number (motile and non-motile cells occurring extracellulary) of cell generations generally increased with each subcultivation, the largest increases (greater than 3-0) occurring in subcultures 4, 5, 7, 8, and 9. Also, the number of motile cells decreased with each subcultivation. Virulent organisms were demonstrated in subcultures 1, 4, 5, 7, and 8, and their numbers estimated with the use of standards established by the animal inoculation titration of counted numbers of organisms freshly harvested from experimental infections; the estimated number of virulent organisms was higher than or equal to the counted cultivated treponemes injected, which may be attributable to uncounted virulent spirochaetes occurring intracellularly.
Prescription Drugs: Comparison of DOD, Medicaid, and Medicare Part D Retail Reimbursement Prices (2014)

Abstract : Why GAO Did This Study. In 2011, federal spending for prescription drugs by DOD, Medicaid, and Medicare Part D totaled $71.2 billion representing about 85 percent of all federal prescription drug expenditures for about 114.4 million beneficiaries. Each program reimbursed retail pharmacies for outpatient prescriptions filled at these pharmacies by their beneficiaries. GAO was asked to compare prices paid for prescription drugs across federal programs. This report compares retail reimbursement prices paid by DOD, Medicaid, and Medicare Part D for a sample of prescription drugs and describes factors affecting these prices. Using agency data for the third quarter of 2010 (the most recent data available at the time of GAO s analysis), GAO selected a sample of 50 high-utilization and 50 high expenditure drugs; after accounting for overlap between the two groups, the final sample contained 78 drugs. GAO calculated average gross unit prices paid to pharmacies by each program by adding total program-paid and beneficiary-paid amounts and dividing by total utilization for each drug, the entire sample, and the subsets of brand-name and generic drugs. GAO calculated net unit prices paid by each program by subtracting all agency reported beneficiary-paid amounts, rebates, refunds, and other price concessions from the gross unit prices. GAO also interviewed DOD, Medicaid, and Medicare Part D officials and reviewed literature describing factors affecting drug prices.
Discordant symptoms in monozygotic twins with familial amyloidotic polyneuropathy (FAP) (TTR Met 30) (1997)

Two monozygotic twin brothers, 55 years of age, are carriers of the TTR Met 30 gene. Twin no. 1 had onset of typical FAP symptoms seven years ago, while twin no. 2 is absolutely healthy. The twins have the same educational background, are working in the same industry and are living in the same area. The progress of symptoms in twin no. 1 was rather rapid with polyneuropathy, gastrointestinal and heart symptoms. Liver transplantation was per-formed in twin no. 1 in 1993, with a successful result. The discordance of FAP symptoms in identical twins might indicate that environmental factors are of importance for the onset of FAP symptoms. The possible importance of environmental factors is indicated by a population study made in the same area. The TTR Met 30 gene carrier frequency is 1.6 per cent, while the frequency of FAP patients in the same area is only 0.05 per cent, indicating a gene penetrance of only about 5 per cent. To our knowledge this is the first report of discordant symptoms in monozygotic twins with ATTR.
An enterprise directory solution with DB2 (2000)

LDAP (Lightweight Directory Access Protocol) is a technology that can provide directory services to a range of applications. Directory service, a critical part of distributed computing, is the central point where network services, security services, and applications can form an integrated distributed computing environment. The simplicity of LDAP enables users to store and retrieve data easily from the directory. Nevertheless, as the use of directory services becomes more widespread, directories will need to scale to support millions of entries and millions of user requests with subsecond predictable performance. LDAP directories can be implemented using various storage mechanisms such as flat files, b-trees, or databases. This paper discusses an implementation of LDAP that uses the IBM DATABASE 2™ relational database as the data store and query engine to meet the directory service requirements. Performance analysis is provided to show that a relational database can be used to successfully meet the performance and scale needs of an LDAP directory while remaining secure and competitive with other vendor implementations.
The Effect of Posture and Duration of Smartphone Usage on Neck Flexion Angle (2019)

The main objective of this study was to measure and examine changes in the neck flexion angle while using a Smartphone according to posture and duration of usage. Photographic analysis procedures were carried out to measure the neck flexion angle. The participants in this study were twenty young adults (half males); they stood against a scaled board and used the same Smartphone for web-browsing for twenty minutes. Photos were taken at zero, five, ten, fifteen and twenty minutes. This procedure was repeated for each participant at three postures (standing, sitting without arms rest, sitting with arms rested on a table). The results revealed statistically significant effects of both posture and duration of usage; neck flexion angle increased significantly over time in all postures and was significantly smaller in the standing posture than in the sitting postures. A significant effect of gender was also identified; males displayed larger neck flexion angles than females.