gebhart/patrepeval huggingface dataset:
SDN Orchestration to Optimize Meshed Millimeter-Wave Backhaul Networks for MEC-Enhanced eMBB Use Cases (2018)

This paper presents a novel concept for enhanced mobile broadband (eMBB) communication using millimeterwave radio technologies enhanced by mobile edge computing to support a new class of applications requiring low latency and high data rates at the same time. The concept developed in the joint European/Japanese collaboration project 5G-MiEdge [1] builds on meshed backhaul topologies using millimeter wave links with beam forming capabilities and smart routing units for dynamic route, link and power management to be orchestrated by SDN. It is shown that dynamic changes in the topology at run time can be realized without experiencing losses in latency or throughput.
Manufacturing Multiple View Constraints (2005)

In this paper we present an algorithm for the gen-eration of the multiple view constraints for arbitrary configurations of cameras and image features corre-spondences. Multiple view constraints are an impor-tant commodity in computer vision since they facilitate in determining camera locations using only the corre-spondences between common features observed in sets of uncalibrated images. We show that by a series of counting arguments and a systematic application of the principles of antisymmetric algebra it is possible to gen-erate arbitrary multiple view constraints in a completely automated fashion. The algorithm has already been uti-lized to discover new sets of multiple view constraints for surfaces. 1.
Secure data hiding in wavelet compressed fingerprint images (2000)

With the rapid growth of the Internet, electronic commerce revenue now amounts to several billion US dollars. To avoid fraud and misuse, buyers and sellers desire more secure methods of authentication than today's userid and password combinations. Automated biometrics technology in general, and fingerprints in particular, provide an accurate and reliable authentication method. However, fingerprint-based authentication requires accessing fingerprint images scanned remotely at the user's workstation, a potentially weak point in the security system. Stored or synthetic fingerprint images might be fraudulently transmitted, even if the communication channel itself is encrypted. In this paper we describe an algorithm for secure data hiding in wavelet compressed fingerprint images to alleviate this problem. Assuming the image capture device is secure, then only the decompressor on the server can locate the embedded message and thereby validate the submitted image.
The asymmetric synthesis of polyfunctional pyrrolidine alkaloids and their analogues (2003)

The aim of this project was to develop a flexible asymmetric synthesis of 1-aza-[2+n.3.0] bicyclic ring systems (n=1,2,3). This was accomplished by the aminolysis of chiral vinyl epoxides followed by ring closing metathesis of the resulting dienes to give a 2,5-dihydropyrroles. These 2,5-dihydropyrroles were very versatile and could readily be converted to the desired 1-azabicyclic ring structures. Further elaboration to natural products was also possible. To this end the synthesis of the indolizidine alkaloid (-)-swainsonine has been developed via two distinct approaches. Furthermore, the (+)-1,2-di-epi- and (+)-1,2,8-tri-epi-swainsonine analogues were prepared using similar methods. The first example of a trihydroxy-pyrrolo[1,2-a]azepine was also prepared. Our efforts to apply the same synthetic approach to the Stemona alkaloids led to the successful synthesis of a pyrrolo-butyrolactone model system. Attempts to elaborate the same methods to the total synthesis of (+)-croomine, were restricted by the extremly hindered nature of the amino-diene core. Nevertheless the BC ring system of (+)-croomine was constructed, and the synthesis proceeded as far as the triol 334 which was, in principle, only three synthetic steps from (+)-croomine. Regrettably transformation of this advanced intermediate into (+)-croomine could not be achieved in the time available.
Firmware Modification Analysis in Programmable Logic Controllers (2014)

Abstract : Incorporating security in supervisory control and data acquisition (SCADA) systems and sensor networks has proven to be a pervasive problem due to the constraints and demands placed on these systems. Both attackers and security professionals seek to uncover the inherent roots of trust in a system to achieve opposing goals. With SCADA systems, a battle is being fought at the cyber -- physical level, specifically the programmable logic controller (PLC). The Stuxnet worm, which became increasingly apparent in the summer of 2010, has shown that modifications to a SCADA system can be discovered on infected engineering workstations on the network, to include the ladder logic found in the PLC. However, certain firmware modifications made to a PLC can go undetected due to the lack of effective techniques available for detecting them. Current software auditing tools give an analyst a singular view of assembly code, and binary difference programs can only show simple differences between assembly codes. Additionally, there appears to be no comprehensive software tool that aids an analyst with evaluating a PLC firmware file for modifications and displaying the resulting effects. Manual analysis is time consuming and error prone. Furthermore, there are not enough talented individuals available in the industrial control system (ICS) community with an in-depth knowledge of assembly language and the inner workings of PLC firmware. This research presents a novel analysis technique that compares a suspected-altered firmware to a known good firmware of a specific PLC and performs a static analysis of differences. This technique includes multiple tests to compare both firmware versions, detect differences in size, and code differences such as removing, adding, or modifying existing functions in the original firmware. A proof-of-concept experiment demonstrates the functionality of the analysis tool using different firmware versions from an Allen-Bradley ControlLogix L61 PLC.
New approaches to the role of sulfhydryl groups in silver stainability of protein in grasshopper chromosomes (1988)

Silver staining in somatic and germ line cells of the grasshopper Arcyptera fusca has been analyzed after a standard silver staining technique was used with pretreatments that included dithiothreitol and β-mercaptoethanol as reagents to maintain —SH groups in the reduced state. The results show that in some tissues, these pretreatments improve not only the silver staining of nucleolar masses but also the recognition of other silver spots associated with the chromatin. These observations are similar to those previously described for the effect of double-strength standard saline citrate on silver staining. The possible chemical nature of the protein groups responsible for the differential silver stainability and the role of saline citrate in the modification of argyrophylic proteins suggested previously are briefly discussed.Key words: Orthoptera, silver staining, sulfhydryl groups.
Conformational control of Pd2L4 assemblies with unsymmetrical ligands (2019)

With increasing interest in the potential utility of metallo-supramolecular architectures for applications as diverse as catalysis and drug delivery, the ability to develop more complex assemblies is keenly sought after. Despite this, symmetrical ligands have been utilised almost exclusively to simplify the self-assembly process as without a significant driving foa mixture of isomeric products will be obtained. Although a small number of unsymmetrical ligands have been shown to serendipitously form well-defined metallo-supramolecular assemblies, a more systematic study could provide generally applicable information to assist in the design of lower symmetry architectures. Pd<sub>2</sub>L<sub>4</sub> cages are a popular class of metallo-supramolecular assembly; research seeking to introduce added complexity into their structure to further their functionality has resulted in a handful of examples of heteroleptic structures, whilst the use of unsymmetrical ligands remains underexplored. Herein we show that it is possible to design unsymmetrical ligands in which either steric or geometric constraints, or both, can be incorporated into ligand frameworks to ensure exclusive formation of single isomers of three-dimensional Pd<sub>2</sub>L<sub>4</sub> metallo-supramolecular assemblies with high fidelity. In this manner it is possible to access Pd<sub>2</sub>L<sub>4</sub> cage architectures of reduced symmetry, a concept that could allow for the controlled spatial segregation of different functionalities within these systems. The introduction of steric directing groups was also seen to have a profound effect on the cage structures, suggesting that simple ligand modifications could be used to engineer structural properties.
Isolation and structures of 1,2,3,4-tetrahydro-1,4-dioxopyrazino[1,2-a]indoles from cultures of Penicillium terlikowskii (1968)

Cultures of Penicillium terlikowskii have been examined for the presence of 1,2,3,4-tetrahydro-1,4-dioxopyrazino-[1,2-a]indoles, as there are theoretical reasons for these being intermediates in the biosynthesis of antibiotics like gliotoxin. Four fractions have been isolated from cultures of the fungus with the required properties, and the structures of three crystalline metabolites obtained therefrom have been determined. One of these (III; R1= OH, R2= H, X = CH2) has the structure postulated for the biosynthetic intermediate of gliotoxin. A number of tetrahydro-1,4-dioxopyrazino[1,2-a]indoles have been synthesised during this work; these syntheses and the physical properties of the compounds are given.
Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart (2000)

Mechanical overload elicits functional and structural adaptive mechanisms in cardiac muscle. Signaling pathways linked to integrin/cytoskeleton complexes may have a function in mediation of the effects of mechanical stimulus in myocardial cells. We investigated the tyrosine phosphorylation and the assembly of the multicomponent signaling complex associated with focal adhesion kinase (Fak) and the actin cytoskeleton in the overloaded myocardium of rats. Pressure overload induced a 3-fold increase in Fak tyrosine phosphorylation within 3 minutes after a 60-mm Hg rise in aortic pressure. A pressure stimulus that lasted for 60 minutes was accompanied by a 5-fold increase in the amount of tyrosine-phosphorylated Fak, and a stimulus as low as 10 mm Hg doubled the amount of tyrosine-phosphorylated Fak in the myocardium within 10 minutes. Pressure overload also induced a time-dependent association of actin with Fak and an increase in the amount of Fak detected in the cytoskeletal fraction of the myocardium. These events were paralleled by c-Src activation and binding to Fak and by an association of Grb2 and p85 subunit of phosphatidylinositol 3-kinase with Fak. Erk1/2 and Akt, two possible downstream effectors of Fak via Grb2 and phosphatidylinositol 3-kinase, were also shown to be activated in parallel with Fak. These findings show that pressure overload induced a rapid activation of the Fak multiple signaling complex in the myocardium of rats, which suggests that this mechanism may have a role in mechanotransduction in the myocardium.
Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke (2020)

Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells' ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials.
Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011 (2015)

The 10-year incidence of localized RNFLDs in adult Chinese is 4.7% ± 0.2%. It is strongly associated with arterial hypertension and higher prevalence of cerebrovascular infarcts, in addition to ocular reasons, such as glaucoma and diabetic retinopathy. Ophthalmologically normal subjects with incident-localized RNFLDs may be screened for arterial hypertension and cerebrovascular infarcts.
Ferroelectric liquid crystals with doping-induced polarization (1988)

Abstract The concept of doping-induced ferroelectricity is described. Physical properties of ferroelectric mixtures and the origin of their spontaneous polarization are discussed.
Direct Numerical Simulation of Homogeneous Isotropic Turbulence with Heat Transport. Prandtl Number Effects. (1993)

Budgets of turbulent heat flux and temperature variance were calculated by direct numerical simulation of decaying homogeneous isotropic turbulence with heat transport. The computations were executed on 963 grid points by a spectral method. With a constant mean temperature gradient imposed in one direction, dependence of the thermal turbulence statistics on the Prandtl number, and the initial temperature variance was studied. The Reynolds number of the simulated turbulent flow field is low. The relative magnitude of the dissipation and the pressure temperature gradient correlation in the turbulent heat flux budget markedly changed at three different Prandtl numbers of 0.2, 0.71 and l.5.
Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagen (1998)

Phosphatidylserine exposure and microvesicle release give rise to procoagulant activity during platelet activation. We have previously shown that whereas the Ca2+ ionophore A23187 and 2,5-di-(t-butyl)-1, 4-benzohydroquinone, a Ca2+-ATPase inhibitor, induce phosphatidylserine exposure, only the former triggers microvesicle release. We now report that microvesicle formation with ionophore A23187 is specifically associated with mu-calpain activation, increased protein tyrosine phosphatase (PTP) activity and decreased tyrosine phosphorylation. The degree to which calpain and individual PTPs were activated in response to A23187 depended on the extent of bivalent cation chelation in the external medium. EGTA (2 mM) blocked or severely retarded their activation, and addition of extracellular Ca2+ in excess (2 mM) resulted in virtually immediate tyrosine dephosphorylation. Dephosphorylation was correlated with an increase in total PTP activity in platelet lysates. In platelets stimulated by a combination of thrombin and collagen, only the subpopulation undergoing microvesicle release and isolated by their binding to annexin-V-coated magnetic beads exhibited protein tyrosine dephosphorylation. Detection of PTP activity in an 'in-gel' assay showed the Ca2+-dependent appearance of active low-molecular-mass bands at 38, 36 and 27 kDa. Individual PTPs varied in their protease sensitivity to changes in intracellular Ca2+ levels. For example, PTP1B was a more sensitive substrate than SH2-domain-containing tyrosine phosphatase-1 for mu-calpain cleavage. Incubation of platelets with the PTP inhibitors, phenylarsine oxide and benzylphosphonic acid acetoxymethyl ester, led to increased tyrosine phosphorylation and the surface expression of aminophospholipids but little microvesicle formation. Furthermore, microvesicle release in response to ionophore A23187 was inhibited. We conclude that platelet microvesicle formation is associated with extensive protein tyrosine dephosphorylation.
MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells (2016)

The neurotransmitter acetylcholine (ACh) promotes the growth and metastasis of several cancers via its M3 muscarinic receptor (M3R). Metastasis-associated in colon cancer-1 (MACC1) is an oncogene that is overexpressed in gastric cancer (GC) and plays an important role in GC progression, though it is unclear how MACC1 activity is regulated in GC. In this study, we demonstrated that ACh acts via M3Rs to promote GC cell invasion and migration as well as expression of several markers of epithelial-mesenchymal transition (EMT). The M3R antagonist darifenacin inhibited GC cell activity in both the presence and absence of exogenous ACh, suggesting GC cells secrete endogenous ACh, which then acts in an autocrine fashion to promote GC cell migration/invasion. ACh up-regulated MACC1 in GC cells, and MACC1 knockdown using siRNA attenuated the effects of ACh on GC cells. AMP-activated protein kinase (AMPK) served as an intermediate signal between ACh and MACC1. These findings suggest that ACh acts via a M3R/AMPK/MACC1 signaling pathway to promote GC cell invasion/migration, which provides insight into the mechanisms underlying GC growth and metastasis and may shed light on new targets for GC treatment.
Formulation and in Vitro — In Vivo Characterization of Solid Dispersions of Piroxicam (1993)

The present work embodies studies performed with solid dispersions of the non-steroidal anti-inflammatory agent piroxicam, using biocompatible water soluble polymers polyethylene glycol (PEG) 4000 and 6000 alone, as well as in blends of various proportions. Different physicochemical properties and in vitro characterization were carried out. In vivo studies were performed to correlate with in vitro studies.
Comparing mathematical and heuristic approaches for scientific data analysis (2007)

Abstract Scientific data is often analyzed in the context of domain-specific problems, for example, failure diagnostics, predictive analysis, and computational estimation. These problems can be solved using approaches such as mathematical models or heuristic methods. In this paper we compare a heuristic approach based on mining stored data with a mathematical approach based on applying state-of-the-art formulae to solve an estimation problem. The goal is to estimate results of scientific experiments given their input conditions. We present a comparative study based on sample space, time complexity, and data storage with respect to a real application in materials science. Performance evaluation with real materials science data is also presented, taking into account accuracy and efficiency. We find that both approaches have their pros and cons in computational estimation. Similar arguments can be applied to other scientific problems such as failure diagnostics and predictive analysis. In the estimation problem in this paper, heuristic methods outperform mathematical models.
High‐Intensity Triboelectrification‐Induced Electroluminescence by Microsized Contacts for Self‐Powered Display and Illumination (2017)

Abstract The conversion of kinetic energy into light emission can produce real‐time self‐powered luminescence. In this work, high‐intensity triboelectrification‐induced electroluminescence (TIEL) is obtained from microsized contacts that have relative sliding motion. The microsized structure significantly promotes the changing rate of the electric field within a luminescent layer. As a result, the produced luminescence intensity is enhanced by two folds compared with a plain‐surface contact. Besides, each microsized contact unit acts as a luminescence pixel. A collection of the contacts can be either designed into patterns or arranged into an array. Therefore, the high‐intensity TIEL presented can be potentially used in self‐powered display and illumination.
Adaptive Filtering-Based Iterative Channel Estimation for MIMO Wireless Communications (2005)

Accurate channel state information (CSI) is a prerequisite for diversity and multiplexing gains in multiple-input multiple-output (MIMO) wireless systems. More refined CSI can be attained by bootstrapping channel estimation techniques. We propose adaptive filtering-based iterative channel estimators with the incorporation of an iterative receiver over a flat-fading MIMO wireless link. The performance of three different algorithms with the aid of hard decision feedback is evaluated and compared through simulations. We show that the least-mean-square algorithm is a reasonable choice among the other considered algorithms in terms of performance and feasibility.
Effects of Tetracyclic and Pentacyclic Triterpenoids on Growth of Phytophthora cactorum (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of Tetracyclic and Pentacyclic Triterpenoids on Growth of Phytophthora cactorumW. David Nes and Glenn W. PattersonCite this: J. Nat. Prod. 1981, 44, 2, 215–220Publication Date (Print):April 1, 1981Publication History Published online1 July 2004Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/np50014a012https://doi.org/10.1021/np50014a012research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts