gebhart/patrepeval huggingface dataset:
Use of load limiting tethers in child restraint systems as a method to mitigate injuries to toddlers in frontal crash (2007)

This research focuses on methods to alleviate head and neck injuries sustained by children seated in forward facing child safety seats during a frontal vehicle crash. According to the Federal Motor Vehicle Safety Standard 213, the maximum limit for head excursion of the child dummy is 720 mm and the neck injury criteria should be less than 0.33 beyond the first 30 ms of the impact. A fully deformable finite element model of a child restraint seat has been previously developed which has been validated for frontal impacts under CMVSS 208 and FMVSS 213 testing conditions. Observations from this previous work have illustrated that despite the head excursion being significantly less than the proposed limit of 720 mm, values of the neck injury criteria exceeded the protection reference values. The main objective of this research was to implement load limiting behavior into the upper and lower tethers of the CRS in order to reduce the neck injury criteria by increasing forward head excursion. Through an analysis of injury criteria, using neck loads and head accelerations, it was observed that load limiting of upper and lower tethers was effective in reducing the head injury criteria and neck injury criteria by approximately 75 per cent and 40 per cent respectively.
An ultra-low-power digitally-controlled buck converter IC for cellular phone applications (2004)

This paper describes a dual-mode digitally-controlled buck converter IC for cellular phone applications. An architecture employing internal power management is introduced to ensure voltage compatibility between a single-cell lithium-ion battery voltage and a low voltage integrated circuit technology. Special purpose analog and digital interface elements are developed. These include a ring-oscillator based ADC (ring-ADC), which is nearly entirely synthesizable, robust against switching noise, and has flexible resolution control, and a very low power ring oscillator-multiplexer based digital PWM generation module (ring-MUX DPWM). The chip, which includes an output power stage rated for 400 mA, occupies 2 mm/sup 2/ active area in 0.25 /spl mu/m CMOS. Very high efficiencies are achieved over a load range of 0.1 to 400 mA. Measured quiescent current in PFM mode is 4 /spl mu/A.
A performance study of transitive closure algorithms (1994)

We present a comprehensive performance evaluation of transitive closure (reachability) algorithms for databases. The study is based upon careful implementations of the algorithms, measures page I/O, and covers algorithms for full transitive closure as well as partial transitive closure (finding all successors of each node in a set of given source nodes). We examine a wide range of acyclic graphs with varying density and “locality” of arcs in the graph. We also consider query parameters such as the selectivity of the query, and system parameters such as the buffer size and the page and successor list replacement policies. We show that significant cost tradeoffs exist between the algorithms in this spectrum and identify the factors that influence the performance of the algorithms.An important aspect of our work is that we measure a number of different cost metrics, giving us a good understanding of the predictive power of these metrics with respect to I/O cost. This is especially significant since metrics such as number of tuples generated or number of successor list operations have been widely used to compare transitive closure algorithms in the literature. Our results strongly suggest that these other metrics cannot be reliability used to predict I/O cost of transitive closure evaluation.
Conducted noise of GaN Schottky barrier diode in a DC–DC converter (2015)

Wide-bandgap power devices such as those made from silicon carbide (SiC) and gallium nitride (GaN) offer superior electrical performance over conventional silicon (Si) devices for high-voltage applications. Their fast switching operation and low switching losses help increase the efficiency of power conversion circuit. This study focuses on the switching characteristics of a GaN Schottky barrier diode (SBD) and investigates the conducted noise characteristics in a DC–DC boost converter by comparing a Si PiN diode and a SiC SBD.
Evaluation of reformulated thermal control coatings in a simulated space environment. Part 1: YB-71 (1994)

The Air Force Space and Missile Systems Center and Wright Laboratory Materials Directorate (WL/ML) have sponsored and effort to effort to reformulate and qualify Illinois Institute of Technology Research Institute (IITRI) spacecraft thermal control coatings. S13G/LO-1, Z93, and YB-71 coatings were reformulated because the potassium silicate binder, Sylvania PS-7, used in the coatings is no longer manufactured. Coatings utilizing the binder's replacement candidate, Kasil 2130, manufactured by The Philadelphia Quartz (PQ) Corporation, Baltimore, Maryland, and undergoing testing at the Materials Directorate's Space Combined Effects Primary Test and Research Equipment (SCEPTRE) Facility operated by the University of Dayton Research Institute (UDRI). The simulated space environment consists of combined ultraviolet (UV) and electron exposure with in site specimen reflectance measurements. A brief description of the effort at IITRI, results and discussion from testing the reformulated YB-71 coating in SCEPTRE, and plans for further testing of reformulated Z93 and S13G/LO-1 are presented.
Influence of driver characteristics on emissions and fuel consumption (2019)

All drivers have individual ways of driving. Still, there are groups of drivers with more or less similar characteristics. In this research, 28 drivers from Chengdu city (P.R. China) participated in an experiment where car following behaviour was measured with GPS devices. In every measured trip there was a leading and following vehicle both equipped with a GPS device. Drivers are classified based on a Driver Behaviour Questionnaire and observed acceleration and deceleration behaviour. The result shows four distinct classes of drivers: macho drivers, careful/inexperienced drivers, smooth going/professional drivers, and experienced/fast drivers. Drivers in the different classes give different emission of air pollution and fuel consumption. Saturation flows are determined from the trajectories and vary between different driver types. The measured trajectories have been analysed in detail to determine some parameters for the Wiedemann 74 model. Most default parameters in the VISSIM program appear to be unsuited for the simulation of driving behaviour measured in the experiment. The emissions and fuel consumption calculated by a simulation model with default parameters are not consistent with the empirical data. The calibration done for different driver types shows that several model parameters are significantly different for the different driver classes.
High performance poly Si junctionless transistors with sub-5nm conformally doped layers by molecular monolayer doping and microwave incorporating CO2 laser annealing for 3D stacked ICs applications (2015)

A junctionless (JL) fin thin film transistor (FinTFT) with a novel shell doping profile (SDP) formed by a damage-free conformal molecular monolayer doping (MLD) method and a combination of microwave annealing (MWA) and CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser spike annealing (COLSA) is demonstrated and studied. MWA drives in and partially activates the MLD dopants; the resultant SDP features an ultra-shallow depth (<; 5nm) and an abrupt steepness (<; 0.8 nm/dec). The dopant activation of the devices experienced MLD and MWA is further enhanced by the nonmelting COLSA without dopant diffusion, and which can also avoid fin deformation and recover surface defects left by fin patterning. Thanks to the enhanced dopant activation by COLSA, the SDP-FinTFTs overall exhibit better performance than the SDP-FinTFTs without COLSA and the conventional implanted (imp) FinTFTs in terms of subthreshold swing (S.S.), on-currents (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> by 160% compared to the SDP-FinTFTs without COLSA) and on/off current ratio (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> ) for 3D stacked ICs applications. Our results reveal the potential of the proposed SDP formed by MLD, MWA and COLSA enabling a JLFinTFT showing excellent performance.
Increasing Reliability on UAV Fading Scenarios (2022)

Unmanned aerial vehicles (UAVs) are the next technology to be incorporated into a telecommunications network to improve command and control on a large scale in both line-of-sight (LOS) and non-line-of-sight (NLOS) conditions. However, there is still room for improvement in terms of reliability. This paper investigates Constant Packet Combining (CPC) and Adaptive Packet Combining (APC) techniques applied to Unmanned Aerial Vehicle (UAV) communication in the presence of large-scale fading, where the channels are subject to sudden degradation for long periods due to obstructions. We use Single Carrier (SC) Frequency Domain Equalization (FDE) combined with the Iterative Block Decision-Feedback Equalizer (IB-DFE) to handle command and control messages mapped for UAV use cases. We present closed-form equations for the equalization design as well as the performance parameters such as Bit Error Rate (BER), the Packet Error Rate (PER), the throughput, the retransmissions amount, the goodput (the transmission rate without the retransmissions quantity), and the outage probability. Then, we analyze the system performance using correlated, independent, and equal channels. There is a trade-off between the overall available power, throughput, and reliability. For instance, more retransmissions result in higher reliability, power consumption and lower goodputs (effective data rates). CPC validates the transmission system and confirms the improvement of BER and PER parameters without energy efficiency optimization. APC is appealing because it can reduce the number of retransmissions for all channels used with the advantage of meeting energy efficiency requirements by adapting the overall power to the scenario experienced by the UAV.
A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells (2019)

Unintentional transduction of B-cell acute lymphoblastic leukemia blasts during CART19 manufacturing can lead to CAR19+ leukemic cells (CARB19) that are resistant to CART19 killing. We developed an anti-CAR19 idiotype chimeric antigen receptor (αCAR19) to specifically recognize CAR19+ cells. αCAR19 CAR T cells efficiently lysed CARB19 cells in vitro and in a primary leukemia-derived xenograft model. We further showed that αCAR19-CART cells could be used as an "antidote" to deplete CART19 cells to reduce long-term side effects, such as B-cell aplasia.
ChIP‐seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization (2012)

OmpR is a multifunctional DNA binding regulator with orthologues in many enteric bacteria that exhibits classical regulator activity as well as nucleoid-associated protein-like characteristics. In the enteric pathogen Salmonella enterica, using chromatin immunoprecipitation of OmpR:FLAG and nucleotide sequencing, 43 putative OmpR binding sites were identified in S. enterica serovar Typhi, 22 of which were associated with OmpR-regulated genes. Mutation of a sequence motif (TGTWACAW) that was associated with the putative OmpR binding sites abrogated binding of OmpR:6×His to the tviA upstream region. A core set of 31 orthologous genes were found to exhibit OmpR-dependent expression in both S. Typhi and S. Typhimurium. S. Typhimurium-encoded orthologues of two divergently transcribed OmpR-regulated operons (SL1068-71 and SL1066-67) had a putative OmpR binding site in the inter-operon region in S. Typhi, and were characterized using in vitro and in vivo assays. These operons are widely distributed within S. enterica but absent from the closely related Escherichia coli. SL1066 and SL1067 were required for growth on N-acetylmuramic acid as a sole carbon source. SL1068-71 exhibited sequence similarity to sialic acid uptake systems and contributed to colonization of the ileum and caecum in the streptomycin-pretreated mouse model of colitis.
Abstract 3755: Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk (2011)

Abstract Background: Systematic genome-wide (global) reductions of methylated cytosine levels have been observed in most cancer tissues, including colorectal cancer, and are hypothesized to contribute to carcinogenesis through genomic instability and protooncogene activation. Recently, genomic DNA hypomethylation has been measured in peripheral blood leukocytes and associated with colorectal tumors. However, as these studies used post-diagnostic specimens, it is possible that the observed findings reflect disease- and/or treatment-induced effects on leukocyte DNA methylation. Methods: Using prospectively collected blood specimens and questionnaire data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we studied genomic leukocyte DNA methylation status in relation to subsequent colorectal cancer risk in a nested case-control study of 370 cases and 493 controls with no cancer diagnosis prior to the blood draw. Genomic leukocyte DNA methylation status was determined by an HPLC/Tandem Mass Spectrometry method and expressed as the relative amount of methyl-cytosine to total cytosine residues, or %5-mC. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using unconditional logistic regression models, adjusting for age, gender, race, time since initial sigmoidoscopy screening, and year of randomization. Inclusion of other suspected colorectal cancer risk factors in the models did not materially change the results. Results: We observed a relatively narrow range of genomic leukocyte DNA methylation levels among cases and controls, with %5-mC ranging from 3.57 to 4.60 (median = 4.03, standard deviation = 0.19). Categorizing subjects by quartiles of %5-mC content in controls, using the lowest quartile as the reference category (Q1), we observed no trend in risk with adjusted ORs (95% CIs) for Q2, 1.44 (1.01-2.08); Q3, 1.06 (0.75-1.51); and Q4, 1.01 (0.70-1.47) (P-trend = 0.49). Dichotomizing subjects by median of %5-mC in controls with the lower %5-mC group as the reference, we found a borderline-significantly decreased risk for subjects with %5-mC above the median (OR = 0.81, CI = 0.61-1.06), particularly among subjects whose natural folate intake levels were above the median (OR = 0.60, CI = 0.39-0.95; P-interaction = 0.06). Conclusion: Preliminary findings from our study, to our knowledge the first prospective investigation of DNA methylation and colorectal cancer, show no clear dose-dependent association between genomic leukocyte DNA methylation status and subsequent cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3755. doi:10.1158/1538-7445.AM2011-3755
Electrochemical Behavior of Benzene, Diphenyl, and p-Terphenyl in Room-Temperature Ionic Liquid N-Butylpyridinium Chloride–AlCl3 (2021)

The cyclic voltammetry method was used for studying the electrochemical oxidation of benzene, diphenyl and p-terphenyl in ionic liquid N-butylpyridinium chloride–AlCl3 (1 : 1.5) at 30°C. Comparative analysis of peaks obtained for each initial monomer was performed. The assumptions on the differences in the mechanisms of electrochemical synthesis of polyphenylenes in the ionic liquid from benzene, diphenyl and p-terphenyl were made.
The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion (2019)

This work has revealed a novel inflammatory mechanism in RA that links FAO to CCL20 production in human monocytes, which could subsequently contribute to RA disease pathogenesis by promoting the recruitment of Th17 cells and osteoclastogenesis.
Da Vinci Assisted Robotic Partial Nephrectomy: Technique and Initial Experience at the Vattikuti Urology Institute (2006)

Littleton, R.; Kaul, S.; Sarle, R.; Laungani, R. G.; Stricker, H.; Peabody, J. O.; Menon, M. Author Information
Novel Synthesis Process of LiFePO4/C Composite Positive Active Material for Li-ion Cells (2010)

Abstract not Available.
The structural origins of the unusual specificities observed in the isolation of chymopapain M and actinidin by covalent chromatography and the lack of inhibition of chymopapain M by cystatin (1995)

1. The selectivity observed when the potentially general technique for the isolation of fully active forms of cysteine proteinases, covalent chromatography by thiol-disulphide interchange, is applied to chymopapain M and to actinidin was investigated by a combination of experimentation and computer modelling. Neither of these enzymes is able to react with the original Sepharose-GSH-2-dipyridyl disulphide gel, but fully active forms of both enzymes are obtained by using Sepharose-2-hydroxypropyl-2'-dipyridyl disulphide gel, which is both electrically neutral and sterically less demanding than the GSH gel. Electrostatic potential calculations, minimization and molecular-dynamics simulations provide explanations for the unusual, but different, specificities exhibited by actinidin and chymopapain M in the interactions of their active centres with ligands. 2. The unique behaviour of chymopapain M in exerting an almost absolute specificity for substrates with glycine at the P1 position and in resisting inhibition by cystatin was examined by the computer-modelling techniques. A new, modelled, structure of the complete chicken egg-white cystatin molecule based on the crystal structure of a short form of cystatin was deduced as a necessary prerequisite. The results suggest that electrostatic repulsion prevents reaction of actinidin with the GSH gel, whereas a steric 'cap' resulting from a unique arginine-65-glutamic acid-23 interaction in chymopapain M prevents reaction of the gel with this enzyme and accounts for the lack of its inhibition by cystatin and its specificity in catalysis. 3. Use of chymopapain M as a structural variant of papain demonstrates the validity of the predictions of Lowe and Yuthavong [Biochem. J. (1971) 124, 107-115] relating to the structural requirements and binding characteristics of the S1 subsite of papain.
What is in a name? Professionals and service users' opinions of the Hebrew terms used to name psychiatric disorders and disability. (2005)

A case for study and possible subsequent action was established by this pilot inquiry.
Instability free routing (2008)

Today, a large body of research exists regarding the correctness of routing protocols. However, many reported global disruptions of Internet connectivity, e.g., inter-AS persistent loops, cannot be explained by looking at a single routing protocol at a time. In fact, these anomalies have long been suspected in the operator community to be caused by the interactions between routing protocols. The interactions between protocol instances are governed by two procedures at the border routers: route selection (RS) ranks routes from different protocol instances; and route redistribution (RR) exchanges routes between protocol instances. Prior studies hypothesized that RR may be responsible for a portion of the observed anomalies. In this paper, we provide analytical and experimental results to link RS, RR, and their interplay to anomalies discovered in operational networks. We show that RS by itself can cause route oscillations and loops, and that in all Cisco, Quagga, and XORP implementations, non-deterministic behaviors may occur because of their incorrect modeling of the dependencies between RS and RR. We identify the root cause for each of the instabilities and derive a configuration guideline as well as a functional model to eliminate them.
Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the QTcF Interval in Humans (2016)

Pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor, has been studied in familial chylomicronemia syndrome. To evaluate the effects of supratherapeutic concentrations of pradigastat on the QTc interval, 2 studies were conducted. The first study assessed the safety, tolerability, and pharmacokinetics of single escalating intravenous doses of pradigastat (10, 30, 100, and 115 mg over 60 minutes) in healthy adults. Single intravenous doses were safe, well tolerated, and at the higher doses resulted in supratherapeutic pradigastat exposure. The second was a parallel, 3-arm thorough QTc study in which healthy male subjects were randomized to pradigastat (115 mg intravenously), moxifloxacin (400 mg oral, positive control), or placebo. Following intravenous administration, pradigastat exposure peaked at 4 times the therapeutic concentration and did not prolong the baseline-adjusted and placebo-corrected QTc intervals. During the 60-minute pradigastat infusion, a number of infusion reactions and a small mean decrease in QTc were observed. Both effects disappeared when the infusion was stopped, suggesting that an infusate excipient may have been responsible. As expected, moxifloxacin significantly increased the QTc interval at multiple points, confirming the study's sensitivity to detect a true positive effect. Pradigastat is therefore unlikely to increase the risk of dysrhythmias associated with QTc prolongation in humans.
4D and multi-phase breath-hold CT imaging with synchronized intravenous contrast injection for liver tumor delineation (2013)

In order to accurately visualize and delineate certain liver tumors on four-dimensional or breath-hold computed tomography images, synchronized intravenous contrast injection is used during simulation at our institution. The purpose of this study is to present these two tumor motion management techniques used for tumor delineation and treatment delivery.
Capacity-Achieving Rate-Compatible Polar Codes (2017)

A method of constructing rate-compatible polar codes that are capacity achieving at multiple code rates with low-complexity sequential decoders is presented. The underlying idea of the construction exploits certain common characteristics of polar codes that are optimized for a sequence of successively degraded channels. The proposed code consists of parallel concatenation of multiple polar codes with information-bit divider at the input of each polar encoder. Thus, it is referred to as parallel concatenated polar (PCP) codes. A lower-rate PCP code is simply constructed by adding more constituent polar codes, which enables incremental retransmissions at different rates in order to adapt to channel conditions. Due to the length limitation of polar codes, the PCP code can only support a restricted set of rates that is characterized by the size of the kernel when conventional polar codes are used. To overcome this limitation, punctured polar codes, which provide more flexibility on blocklength by controlling a puncturing fraction, are considered as constituent codes. The existence of capacity-achieving punctured polar codes for any given puncturing fraction is proven. Using such punctured polar codes as constituent codes, it is shown that the proposed PCP code is capacity achieving for an arbitrary sequence of rates and for any class of degraded channels.