gebhart/patrepeval huggingface dataset:
AMOS: comparison of scan matching approaches for self-localization in indoor environments (2002)

This paper describes results from evaluating different self-localization approaches in indoor environments for mobile robots. The algorithms examined are based on 2D laser scans and an odometry position estimate and do not need any modifications in the environment. An important requirement for the self-localization is the ability to cope with office-like environments as well as with environments without orthogonal and rectilinear walls. Furthermore, the approaches have to be robust enough to cope with slight modifications in the daily environment and should be fast enough to be used online on board of the robot system. To fulfil these requirements we made some extensions to the existing approaches and combined them in a suitable manner. Real world experiments with our robot within the everyday environment of our institute show that the position error can be kept small enough to perform navigation tasks.
Multiphoton-scattering theory and generalized master equations (2015)

The analysis of photon scattering is a major challenge in the multiphoton regime. A framework based on a path-integral formalism provides a route to explore such dynamics, helping to investigate the quantum statistics of photons interacting with complex structures.
Fabrication of high aspect ratio optical light pipes (2009)

We report fabrication techniques for high aspect ratio vertical light pipes in a 10μm thick SiO2 layer. Light pipes with an aspect ratio of 2.8:1 and a sidewall angle of 89.5o were demonstrated. © 2009 Optical Society of America.
Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know? (2018)

Numerous conditions, including cancer, diabetes, aging, and atherosclerosis, are thought to be associated with oxidative stress. Oxidative stress is defined as a persistent imbalance between oxidation and antioxidation, resulting in the damage of cellular macromolecules and is often considered to be involved in wide variety of human diseases. However, the current literature is very heterogeneous making it rather difficult to draw general conclusions. Often, different biomarkers have been used in different health problems. In addition, individual biomarkers are often measured using nonspecific methods. The development of informative and highly reliable markers is very important. The conflicting results of numerous studies, including clinical trials, make it clear that despite the explosion of studies performed in the last decades, leading to nutritional guidelines recommending consumption of food-related antioxidants, direct proof is still lacking.
Orthogonal projections to latent structures (O‐PLS) (2002)

Abstract A generic preprocessing method for multivariate data, called orthogonal projections to latent structures (O‐PLS), is described. O‐PLS removes variation from X (descriptor variables) that is not correlated to Y (property variables, e.g. yield, cost or toxicity). In mathematical terms this is equivalent to removing systematic variation in X that is orthogonal to Y . In an earlier paper, Wold et al. ( Chemometrics Intell. Lab. Syst . 1998; 44 : 175–185) described orthogonal signal correction (OSC). In this paper a method with the same objective but with different means is described. The proposed O‐PLS method analyzes the variation explained in each PLS component. The non‐correlated systematic variation in X is removed, making interpretation of the resulting PLS model easier and with the additional benefit that the non‐correlated variation itself can be analyzed further. As an example, near‐infrared (NIR) reflectance spectra of wood chips were analyzed. Applying O‐PLS resulted in reduced model complexity with preserved prediction ability, effective removal of non‐correlated variation in X and, not least, improved interpretational ability of both correlated and non‐correlated variation in the NIR spectra. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Filiation entre cellules endothéliales et cellules souches hématopoïétiques intraembryonnaires (1999)

Nous avons étudié chez l’Oiseau les relations de développement entre les lignages endothélial et hématopoïétique dans le plancher de l’aorte qui constitue un site intraembryonnaire d’émergence hématopoïétique. L’endothélium aortique exprime la molécule VEGF-R2 spécifique de l’endothélium avant l’apparition des premières cellules hématopoïétiques au sein de l’embryon. Le début de l’hématopoïèse peut être déterminé en détectant l’antigène pan-leucocytaire CD45. Les bourgeonnements intra-aortiques sont CD45+/VEGF-R2- alors que le reste de l’endothélium est CD45-/VEGF-R2+, les deux antigènes s’expriment donc de façon complémentaire dans le plancher de l’aorte. Afin de déterminer si les bourgeonnements intra-aortiques dérivent des cellules endothéliales, nous avons marqué les cellules endothéliales de l’arbre vasculaire à deux jours de développement (E2) avec des LDLs (Low Density Lipoproteins) couplées à un marqueur fluorescent ou des vecteurs rétroviraux non-réplicatifs. Vingt-quatre heures après l’inoculation, les bourgeonnements intra-aortiques sont marqués. Deux à trois jours plus tard des groupes de cellules hématopoïétiques positives sont trouvées dans les foyers para-aortiques. Comme aucune cellule hématopoïétique n’est insérée dans l’arbre vasculaire au moment du marquage, les bourgeonnements intra-aortiques et les foyers para-aortiques dérivent donc de progéniteurs possédant un phénotype endothélial.
Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses (1998)

Eight healthy male, Vietnamese subjects were administered 1 x 250, 2 x 250, and 4 x 250 mg artemisinin capsules in a cross-over design with randomized sequence with a 7-day washout period between administrations. The inter-individual variability in artemisinin pharmacokinetics was large with parameter coefficient of variation (CV) typically between 50-70%. The parameter with the smallest variability was the elimination half-life (CV approximately equal to 30-40%). Analysis of variance indicated also a large intra-subject variability. (CV, or = 24%) for the dose-normalized area under the plasma concentration-time curve (AUC/dose). The pharmacokinetic results suggested artemisinin to be subject to high pre-systemic extraction. Artemisinin half-life could not predict the extent of in vivo exposure to the drug, there being no correlation between half-life and oral clearance. Artemisinin oral plasma clearance was about 400 L h-1 exhibiting a slight decrease with dose, although the effect was weak. Thus results from studies using different artemisinin doses may, within the studied dose range, be compared without the complication of disproportionate changes in drug exposure with varying dose levels. Half-lives appeared to increase with dose. An observed period effect in the analysis of variance was tentatively associated with time-dependency in artemisinin pharmacokinetics. There was a high correlation between artemisinin plasma concentrations determined at various time-points after drug administration and the AUCs after the 500 and 1000 mg doses, but less so after the 250 mg dose. This may show a tentative approach to assess the systemic exposure of the patients to artemisinin from the determination of artemisinin plasma concentrations in one or two plasma samples only. Artemisinin was well tolerated with no apparent dose or time dependent effects on blood pressure, heart rate or body temperature.
Effect of META060, a substituted 1,3‐cyclopentadione compound derived from hops, in the management of obesity (2013)

In search of phytochemicals with anti‐inflammatory properties – which may also be useful in obesity management – we discovered candidate META060, a family of substituted‐1,3‐cyclopentadiones derived from hops. In vitro, META060 inhibited kinases (e.g. PI3Kβ/δ/γ, GSK3α/β, BTK and SYK) involved in NF‐κB pathway and reduced NF‐κB nuclear abundance. It reduced inducible COX‐2 and iNOS abundance and PGE 2 and nitric oxide production in LPS‐stimulated macrophages. In vivo, META060 reduced acute and chronic inflammation in arthritic mice, and lowered fasting glucose and insulin in db/db mice at parity to Metformin. In mice fed a high‐fat diet, META060 prevented weight gain (including liver weight gain and subcutaneous/epididymal fat accumulation), reduced metabolic endotoxemia, and up‐regulated tight junction proteins zonula occludens‐1 and occludin. We designed a randomized controlled trial to test META060 (400 mg/day t.i.d. versus placebo) on short‐term weight loss (Phase 1) and long‐term weight maintenance (Phase 2) in obese individuals. Phase 1 was a 12‐week ketogenic style (high‐protein, low‐carbohydrate) weight loss program (1000–1100 calories/day); Phase 2 a 52‐week lifestyle program without caloric restriction. Preliminary data showed that at the end of Phase 2, participants receiving META060 retained 107% of the mean 26.5 lb (11.5% body weight loss) lost during Phase 1. Supported by Metagenics Inc.
Wavelet-Domain Soft-Thresholding for Non-Stationary Noise (2006)

This paper describes a new wavelet-based denoising algorithm based on a non-stationary noise assumption. Even though stationary noise models can simplify the development and implementation of denoising algorithms, they do not always accurately describe the statistical properties of the noise. The proposed algorithm has been developed to address signal processing problems under environments where the noise is spatially varying. We illustrate two signal denoising examples in order to show the performance of the proposed algorithm.
Intracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process (2017)

A key goal in process development for antibodies is to increase productivity while maintaining or improving product quality. During process development of an antibody, titers were increased from 4 to 10 g/L while simultaneously decreasing aggregates. Process development involved optimization of media and feed formulations, feed strategy, and process parameters including pH and temperature. To better understand how CHO cells respond to process changes, the changes were implemented in a stepwise manner. The first change was an optimization of the feed formulation, the second was an optimization of the medium, and the third was an optimization of process parameters. Multiple process outputs were evaluated including cell growth, osmolality, lactate production, ammonium concentration, antibody production, and aggregate levels. Additionally, detailed assessment of oxygen uptake, nutrient and amino acid consumption, extracellular and intracellular redox environment, oxidative stress, activation of the unfolded protein response (UPR) pathway, protein disulfide isomerase (PDI) expression, and heavy and light chain mRNA expression provided an in-depth understanding of the cellular response to process changes. The results demonstrate that mRNA expression and UPR activation were unaffected by process changes, and that increased PDI expression and optimized nutrient supplementation are required for higher productivity processes. Furthermore, our findings demonstrate the role of extra- and intracellular redox environment on productivity and antibody aggregation. Processes using the optimized medium, with increased concentrations of redox modifying agents, had the highest overall specific productivity, reduced aggregate levels, and helped cells better withstand the high levels of oxidative stress associated with increased productivity. Specific productivities of different processes positively correlated to average intracellular values of total glutathione. Additionally, processes with the optimized media maintained an oxidizing intracellular environment, important for correct disulfide bond pairing, which likely contributed to reduced aggregate formation. These findings shed important understanding into how cells respond to process changes and can be useful to guide future development efforts to enhance productivity and improve product quality.
Optical dephasing of impurity transitions in amorphous solids from diagonal modulation: application of nonphenomenological distribution functions (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical dephasing of impurity transitions in amorphous solids from diagonal modulation: application of nonphenomenological distribution functionsR. Jankowiak and G. J. SmallCite this: J. Phys. Chem. 1986, 90, 22, 5612–5615Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/j100280a027https://doi.org/10.1021/j100280a027research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Aperture Shape Optimization Based on Fuzzy Enhancement (2018)

The aperture shape optimization (ASO) is a critical step in the direct aperture optimization (DAO) method. During ASO, the gradient of objective function is calculated with respect to the beamlet weight. These gradient components are directly utilized to generate the new aperture shape. In this way, the beamlet of the large positive gradient value may be grouped into the generated aperture shape. The treatment quality may be deteriorated by adding this aperture into the treatment plan. In order to overcome this drawback, a novel method based on the fuzzy enhancement was proposed to generate the aperture shape. We apply the fuzzy enhancement method to enhance the gradient map that is composed of the gradients of objective function in a beam. The enhanced gradient map was then employed to form a network flow, which was solved to generate the new aperture shape. The optimal aperture shape was generated by removing the beamlet of the large positive gradient value from the new generated aperture shape. To verify the effectiveness, the proposed method was compared with the conventional column generation (CG) method on a prostate cancer case and on a head-and-neck cancer case. Experimental results demonstrate that the new algorithm has a better performance than the CG algorithm. The proposed method can further reduce the dose delivered to the critical structures, when the similar dose coverage is delivered on the targets.
A Reinforcement Learning Approach for Fast Frequency Control in\n Low-Inertia Power Systems (2020)

The electric grid is undergoing a major transition from fossil fuel-based\npower generation to renewable energy sources, typically interfaced to the grid\nvia power electronics. The future power systems are thus expected to face\nincreased control complexity and challenges pertaining to frequency stability\ndue to lower levels of inertia and damping. As a result, the frequency control\nand development of novel ancillary services is becoming imperative. This paper\nproposes a data-driven control scheme, based on Reinforcement Learning (RL),\nfor grid-forming Voltage Source Converters (VSCs), with the goal of exploiting\ntheir fast response capabilities to provide fast frequency control to the\nsystem. A centralized RL-based controller collects generator frequencies and\nadjusts the VSC power output, in response to a disturbance, to prevent\nfrequency threshold violations. The proposed control scheme is analyzed and its\nperformance evaluated through detailed time-domain simulations of the IEEE\n14-bus test system.\n
Azo Compounds. XXXVIII. The Mercuric Oxide Oxidation of 1-Amino-2-phenylpiperidine1 (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzo Compounds. XXXVIII. The Mercuric Oxide Oxidation of 1-Amino-2-phenylpiperidine1C. G. OVERBERGER and LOUIS P. HERINCite this: J. Org. Chem. 1962, 27, 2, 417–422Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/jo01049a018https://doi.org/10.1021/jo01049a018research-articleACS PublicationsRequest reuse permissionsArticle Views349Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ratio of creatine/betaine in the liver of mouse DEN-initiated HCC model from Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model (2023)

&lt;p&gt;Boxplot of quantitative data displays the full range of variation (from min to max). n.s., not significant.&lt;/p&gt;
Etude d'un évaporateur air-CO 2 dans une boucle secondaire d'un système de réfrigération (2007)

Le CO2 possede des proprietes thermo physiques interessantes et du fait de son caractere inoffensif pour l'environnement, il represente une bonne alternative aux refrigerants synthetiques. L'evaporateur est l'une des composantes principales dans un systeme de refrigeration. Une conception adequate, visant a tirer avantage du CO2 est importante pour la performance du systeme. Pour ce faire, un modele theorique base sur une approche incrementale a ete developpe pour un evaporateur air/CO2 de type tube a ailettes. La concordance entre les resultats de calcul et les mesures obtenues au laboratoire est satisfaisante. L'analyse a fait ressortir certains avantages du CO2tels que : les faibles pertes de charge et la faible variation de la temperature d'evaporation, ce qui permet de concevoir de longs circuits. Une distribution uniforme de temperature et d'humidite d'air a ete obtenue.
Multiscale wavelet support vector machine for image approximation (2007)

In this paper, a new multiscale wavelet support vector machines model (MWSVM) is proposed, according to the Mercer condition, the wavelet frame theory and kernel function nature. From the statistical learning theory and the SVM model, pointed out the SVM essence is kernel method, the different kernel function has decided the different SVM. The choice of kernel parameters is simplified in MWSVM. By the experiment with the single-variable two-variable function and real image, the new model can approach linear and the non-linear combination functions very well. The experimental result shows that MWSVM is the validity and the usability.
Auralization-An Overview (1993)

Auralization is a term introduced to be used in analogy with visualization to describe rendering audible (imaginary) sound fields. Several modeling methods are available in architectural acoustics for this purpose. If auralization is done by computer modeling, it can be thought of as true acoustical computer-aided design. Together with new hardware implementations of signal processing routines, auralization forms the basis of a powerful new technology for room simulation and aural event generation. The history, trends, problems, and possibilities of auralization are described. The discussion primarily deals with auralization of auditorium acoustics andloudspeaker installations. The advantages and disadvantages of various approaches are discussed, as are possible testing and verification techniques. The possibility of using acoustic scale models for auralization is also discussed. Demonstrations of auralization have been made, but still the technology's ability to reproduce the subjective impression of the audible characteristics of a hall accurately remains to be verified. This limits the credibility of auralization as a design tool, and verification of auralization the foremost problem to be attacked at this time. The verification problem also applies to the basic room impulse response prediction programs. The combination of auralization with transaural reproduction, room equalization, and active noise control could make it possible to expand the applications of the technology beyond the laboratory and beyond simple headphone reproduction. A large number of interesting applications outside room and psychoacoustics research are conceivable, the most interesting of which are probably its use in information, education, and entertainment.
Image indexing using vector quantization (1995)

Recently, several image indexing techniques have been reported in the literature. However, these techniques require a large amount of off-line processing, additional storage space and may not be applicable to images stored in compressed form. In this paper, we propose two efficient techniques based on vector quantization (VQ) for image indexing. In VQ, the image to be compressed is decomposed into L-dimensional vectors. Each vector is mapped onto one of a finite set (codebook) of reproduction vectors (codewords). The labels of the codewords are used to represent the image. In the first technique, for each codeword in the codebook, a histogram is generated and stored along with the codeword. We note that the superposition of the histograms of the codewords, which are used to represent an image, is a close approximation of the histogram of the image. This histogram is used as an index to store and retrieve the image. In the second technique, the histogram of the labels of an image is used as an in index to access the image. The proposed techniques provide fast access to the images in the database, have lower storage requirements and combine image compression with image indexing. Simulation results confirm the gains of the proposed techniques in comparison with other techniques reported in the literature.