gebhart/patrepeval huggingface dataset:
Circulating microRNA-636 is associated with the elimination of hepatitis C virus by ombitasvir/paritaprevir/ritonavir (2018)

Hepatitis C virus (HCV) infection causes sustained inflammation and fibrosis. Several oral direct-acting antivirals (DAAs) including ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) were recently developed for HCV elimination. The combination of DAAs brought a higher sustained viral response (SVR) rate to anti-HCV therapy compared to interferon (IFN)-based regimens. However, 5% of hepatitis C patients who undergo DAA therapy still suffer from a sustained HCV infection. MicroRNA (miRNA) is essentially interfering, endogenous noncoding RNA that has been investigated as a new biomarker for the response to DAA in hepatitis C patients. Here we used a miRNA array and real-time polymerase chain reaction (PCR) to determine the targetable miRNA before and 12 weeks after OBV/PTV/r treatment for refractory hepatitis C. We used replicon cells, in which genotype 1b type HCV is stably transfected in Huh7 cells, to determine whether miRNA can inhibit HCV replication. Among 2,555 miRNAs, three were significantly up-regulated and eight miRNAs were down-regulated in serum 12 weeks after OBV/PTV/r treatment. An unsupervised hierarchical clustering analysis, using Pearson's correlation, showed that the miRNA profiles between before and 12 weeks after OBV/PTV/r treatment were clustered separately. At 12 weeks after OBV/PTV, miR-636 was targeted among the eight down-regulated miRNAs, and the expression level of circulating miR-636 was significantly diminished. The amount of HCV-RNA was significantly diminished 48 hours after miR-636 inhibitor transfection in HCV replicon cells. In conclusion, miR-636 might be one of the essential targetable molecules in HCV patients who undergo DAA therapy and still suffer from a sustained HCV infection.
Deep Neural Networks for Improved, Impromptu Trajectory Tracking of Quadrotors (2016)

Trajectory tracking control for quadrotors is important for applications ranging from surveying and inspection, to film making. However, designing and tuning classical controllers, such as proportional-integral-derivative (PID) controllers, to achieve high tracking precision can be time-consuming and difficult, due to hidden dynamics and other non-idealities. The Deep Neural Network (DNN), with its superior capability of approximating abstract, nonlinear functions, proposes a novel approach for enhancing trajectory tracking control. This paper presents a DNN-based algorithm as an add-on module that improves the tracking performance of a classical feedback controller. Given a desired trajectory, the DNNs provide a tailored reference input to the controller based on their gained experience. The input aims to achieve a unity map between the desired and the output trajectory. The motivation for this work is an interactive "fly-as-you-draw" application, in which a user draws a trajectory on a mobile device, and a quadrotor instantly flies that trajectory with the DNN-enhanced control system. Experimental results demonstrate that the proposed approach improves the tracking precision for user-drawn trajectories after the DNNs are trained on selected periodic trajectories, suggesting the method's potential in real-world applications. Tracking errors are reduced by around 40-50% for both training and testing trajectories from users, highlighting the DNNs' capability of generalizing knowledge.
Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences (2022)

In the development and manufacture of fermented foods, it is crucial to control and manage the bacterial species used in the products. We previously reported a complete genome sequence analysis of the <i>Enterococcus faecalis</i> EF-2001 strain that was used for supplements. By comparing this sequence to the publicly available complete genome sequence of <i>E. faecalis</i> strains, we were able to identify specific sequences of the EF-2001 strain. We designed primer sets to amplify these specific regions and performed a polymerase chain reaction (PCR). We confirmed that the DNA fragments were specifically amplified in the genome of the EF-2001 strain, but not those of other lactic acid bacteria (LABs) or strains of the same genus. Furthermore, these primers amplified DNA fragments even in genomic DNA extracted from heat-treated bacteria at 121°C and foods containing the EF-2001 strain. These results suggest that this method allows for simple and highly accurate identification of specific fermentation strains, such as LABs at the strain level, which will be useful for controlling the quality of fermented foods.
An Efficient MAC Protocol with Selective Grouping and Cooperative Sensing in Cognitive Radio Networks (2013)

In cognitive radio networks, spectrum sensing is a crucial technique to discover spectrum opportunities for the Secondary Users (SUs). The quality of spectrum sensing is evaluated by both sensing accuracy and sensing efficiency. Here, sensing accuracy is represented by the false alarm probability and the detection probability while sensing efficiency is represented by the sensing overhead and network throughput. In this paper, we propose a group-based cooperative Medium Access Control (MAC) protocol called GC-MAC, which addresses the tradeoff between sensing accuracy and efficiency. In GC-MAC, the cooperative SUs are grouped into several teams. During a sensing period, each team senses a different channel while SUs in the same team perform the joint detection on the targeted channel. The sensing process will not stop unless an available channel is discovered. To reduce the sensing overhead, an SU-selecting algorithm is presented to selectively choose the cooperative SUs based on the channel dynamics and usage patterns. Then, an analytical model is built to study the sensing accuracy-efficiency tradeoff under two types of channel conditions: time-invariant channel and time-varying channel. An optimization problem that maximizes achievable throughput is formulated to optimize the important design parameters. Both saturation and non-saturation situations are investigated with respect to throughput and sensing overhead. Simulation results indicate that the proposed protocol is able to significantly decrease sensing overhead and increase network throughput with guaranteed sensing accuracy.
Physical Growth Velocity during Conservative Treatment and following Subsequent Surgical Treatment for Primary Vesicoureteric Reflux (1989)

Physical growth was studied in 6 males and 16 females during 1 year of antimicrobial prophylaxis and during the 2 years following subsequent surgical treatment for severe primary vesicoureteric reflux. Surgery was performed between the ages of 2 and 8 because of either repeated breakthrough infection or persistence of grade III or IV reflux. Height and weight velocities were calculated as yearly rates and then converted into interquartile ratios (IQRs). Neither the mean centile height nor weight attained varied significantly between that at entry, after 1 year of medical treatment and at 2 years after surgery. However, the mean IQR for height velocity (+/- sem) rose significantly from -0.61 (+/- 0.45) during antimicrobial prophylaxis to 0.54 (+/- 0.25) following surgery. Similarly, the mean IQR for weight velocity rose significantly from -0.63 (+/- 0.50) during medical treatment to 0.47 (+/- 0.24) following surgery. These results suggest that surgical treatment is preferable to continued medical treatment in patients with severe primary vesicoureteric reflux who fail to respond to a trial of antimicrobial prophylaxis.
Evolution of damping in ferromagnetic/nonmagnetic thin film bilayers as a function of nonmagnetic layer thickness (2016)

The evolution of damping in Co/Pt, Co/Au, and ${\mathrm{Ni}}_{81}{\mathrm{Fe}}_{19}$/Pt bilayers was studied with increasing nonmagnetic (NM) heavy-metal layer thicknesses in the range $0.2\phantom{\rule{0.28em}{0ex}}\phantom{\rule{4pt}{0ex}}\mathrm{nm}\ensuremath{\le}{t}_{\mathrm{NM}}\ensuremath{\le}10\phantom{\rule{0.28em}{0ex}}\phantom{\rule{4pt}{0ex}}\mathrm{nm}$, where ${t}_{\mathrm{NM}}$ is the NM layer thickness. Magnetization precession was measured in the time domain using time-resolved magneto-optical Kerr effect magnetometry. Fitting of the data with a damped sinusoidal function was undertaken in order to extract the phenomenological Gilbert damping coefficient $\ensuremath{\alpha}$. For Pt-capped Co and ${\mathrm{Ni}}_{81}{\mathrm{Fe}}_{19}$ layers a large and complex dependence of $\ensuremath{\alpha}$ on the Pt layer thickness was observed, while for Au capping no significant dependence was observed. It is suggested that this difference is related to the different localized spin-orbit interaction related to intermixing and to $d\text{\ensuremath{-}}d$ hybridization of Pt and Au at the interface with Co or ${\mathrm{Ni}}_{81}{\mathrm{Fe}}_{19}$. Also it was shown that damping is affected by the crystal structure differences in FM thin films and at the interface, which can modify the spin-diffusion length and the effective spin-mixing conductance. In addition to the intrinsic damping an extrinsic contribution plays an important role in the enhancement of damping when the Pt capping layer is discontinuous. The dependence of damping on the nonmagnetic layer thickness is complex but shows qualitative agreement with recent theoretical predictions.
ChemInform Abstract: Hammett ϱ+ Values as Kinetic Evidence for the Concerted Biomimetic Bicyclization Mechanism. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic modeling of a solar receiver/thermal energy storage system based on a compartmented dense gas fluidized bed (2017)

Fluidized beds may be considered a promising option to collection and storage of thermal energy of solar radiation in Concentrated Solar Power (CSP) systems thanks to their excellent thermal properties in terms of bed-to-wall heat transfer coefficient and thermal diffusivity and to the possibility to operate at much higher temperature. A novel concept of solar receiver for combined heat and power (CHP) generation consisting of a compartmented dense gas fluidized bed has been proposed to effectively accomplish three complementary tasks: collection of incident solar radiation, heat transfer to the working fluid of the thermodynamic cycle and thermal energy storage. A dynamical model of the system laid the basis for optimizing collection of incident radiative power, heat transfer to the steam cycle, storage of energy as sensible heat of bed solids providing the ground for the basic design of a 700kWth demonstration CSP plant.
[Techniques, tactics and organizational aspects of distant procurement of donor hearts for transplantation. Experience at the Department of Cardiovascular and Transplantation Surgery of IKEM with 100 distant procurement of donor hearts]. (1998)

Transplantation of the heart is currently an accepted therapeutic method. One of the factors which have an adverse effect on its availability is shortage of suitable donors. Distant procurement of hearts helps to extend the number of organs for transplantations. The authors present their experience with distant procurement of donor hearts performed during more than three years. They evaluate the influence of cold ischaemia time of the cardiac graft on early results of cardiac transplantations. In the discussion they try to draw attention to some problems associated with this technique for other organ retrieval teams participating in multiple organ procurement.
A Quantitative Framework to Identify and Prioritize Opportunities in Biomedical Product Innovation (2023)

In this cross-sectional pilot study, we developed and implemented a data-driven, proof-of-concept model that can help identify, quantify, and prioritize opportunities for biomedical product innovation. Quantifying the relative alignment between biomedical product innovation, public health burden, and health care cost may help identify and prioritize investments that can have the greatest public health benefit.
Automatic lane following with a single camera (2002)

The objective of this research is to monitor the vehicle motion against its external and internal constraints and to remove the existing safety risk, if any, based on the human-machine cooperative vehicle control. We begin by solving the problem of automatic lane following of a vehicle, where a vision system with a single camera installed inside the vehicle is used for identifying the vehicle pose with reference to the lane that the vehicle is following. To perform this task, the road with lanes was modeled by three connected plates. The perception net based method is proposed to identify lane and to estimate vehicle pose under all weather and lighting conditions as well as variations of the road conditions. As a result, the lane to follow under large noise as well as variants embedded in the street images can be identified. The 3D geometric relationship between the lane and the vehicle is also determined.
Exploration of the Difference in Molecular Structure of n-C7 and CO2 Induced Asphaltenes (2018)

Determination of the molecular structure of asphaltenes, especially in their native environment, is a formidable challenge in petroleum chemistry. Here we demonstrate that a combination of different spectroscopy and imaging based experimental techniques can be utilized to determine structures of asphaltenes, which have precipitated out of a crude oil, in an environment similar to real field conditions. A high pressure–high temperature quartz crystal microbalance (HPHT-QCM) setup can be used to detect asphaltene onset at oil production conditions. HPHT-QCM can also simulate CO2 injection conditions mimicking gas injection methods used to enhance oil recovery from depleted oil reservoirs. In this paper, we present the first compositional and structural research study on the QCM asphaltene deposits under gas injection conditions and compare it to n-C7 asphaltenes from the same crude oil precipitated in the laboratory. This study combines the use of Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR), environmental scanning electron microscopy (ESEM), and energy dispersive X-ray (EDX) analysis. Furthermore, deposits collected from chemically treated fluids were also studied. The HPHT-QCM asphaltene deposits from parent crude oil are richer in oxygen species, such as the Ox and R–OH polar groups, relative to the n-C7 asphaltenes. The results of this study provide high-pressure information that leads to better understanding of asphaltene precipitation and deposition phenomena and could be taken into account when designing prevention strategies to avoid asphaltene problems throughout the oil production process.
Fine‐needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma (2004)

Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm derived from FDCs in lymphoid tissue. Metastatic FDCS to the liver is rare. We present a case of a 65-yr-old woman who was referred to our institution 1 mo after splenectomy for FDCS of the spleen. An abdominal CT scan revealed a 2.0-cm liver lesion, which led to fine-needle aspiration (FNA) biopsy. Smears of the aspiration obtained were hypercellular showing a pleomorphic population of large oval to spindle-shaped tumor cells against a background of small mature lymphocytes, plasma cells, and necrotic debris. Tumor cells were arranged singly, in syncytial or fascicular patterns, and had a moderate amount of cytoplasm and indistinct cell borders. Nuclei had irregular nuclear membranes, finely granular to vesicular chromatin, and prominent nucleoli. Multinucleated and binucleated cells resembling Reed-Sternberg cells were noted occasionally. Mitotic figures, including atypical forms, were frequently identified. The diagnosis of "pleomorphic malignant spindle-cell neoplasm consistent with metastatic FDCS" was rendered and later confirmed by histological review and immunohistochemical staining of the subsequent liver resection specimen. Although cytological features of FDCS are characteristic, they are overlapping with those of many other tumors. We review the literature on this entity with emphasis on FNA cytomorphology, differential diagnosis, and immunohistochemical findings.
ChemInform Abstract: Catalytic Asymmetric Epoxidation of Cyclic Enones. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Study of Reaction Kinetics by Near-Infrared Spectroscopy. 2. Comparison with Dielectric Spectroscopy of Model and Multifunctional Epoxy/Amine Systems (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study of Reaction Kinetics by Near-Infrared Spectroscopy. 2. Comparison with Dielectric Spectroscopy of Model and Multifunctional Epoxy/Amine SystemsJovan Mijovic, Sasa Andjelic, C. F. Winnie Yee, Francesco Bellucci, and Luigi NicolaisCite this: Macromolecules 1995, 28, 8, 2797–2806Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ma00112a027https://doi.org/10.1021/ma00112a027research-articleACS PublicationsRequest reuse permissionsArticle Views454Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Activity of Sangrovit® against Lawsonia intracellularis in grower pigs and its impact on gut physiology and host immunity (2011)

Sanguinarine, a quaternary benzophenanthridine alkaloid plant extract of Macleya cordata, has demonstrated to have anti-inflammatory, antimicrobial and immunomodulatory effect. It increases the availability of aromatic amino acids and decreases the levels of toxic biogenic amines. This study was aimed to evaluate the effect of Sangrovit supplementation as compared to tylosin on growth performance, feed efficiency and Lawsonia intracellularis shedding in pigs, and to determine the effect of Sangrovit on the immune system. A total of 24 pigs, four weeks-old challenged with Lawsonia intracellularis were randomly allocated to a treatment group (control non-supplemented, 40 g Sangrovit /mton, 75 g Sangrovit /mton, and 22g /kg tylosin). Pigs were weighed weekly and average daily gain (ADG), average daily feed intake (ADFI) and gain to feed ratio (G:F) were calculated. Fecal samples were collected weekly for isolation and quantification of Lawsonia intracellularis using qPCR as well as blood samples for determination of IgA and IgG levels. After 21 days (acute phase), three pigs from each treatment group were euthanized for recording of lesions of the acute phase of the disease; the remaining 12 pigs were euthanized 90 days after challenge (chronic phase). Results showed that ADG and ADFI was higher for pigs receiving tylosin as compared to the other groups (p>0.05). Pigs receiving 75 gr. Sangrovit /mton showed a higher G:F ratio as compared to the other groups (p>0.05). None of the treatment groups showed significant differences in Lawsonia shedding level based on quantitative PCR. Only control group presented characteristic lesions of Lawsonia infection at the acute stage of the disease (21 days). At the chronic stage, the highest ileum thickness score was observed in pigs receiving tylosin. Findings suggest that Sangrovit supplementation is effective for improving growth performance and reducing pathognomonic lesions. Further studies are needed to determine the effect of Sangrovit on the immune system.
An Extremal Problem for Vertex Decomposition of Complete Multipartite Graphs (2013)

A graph is finite and undirected with no multiple edge or loop. Let H be a family of graphs. For a graph G, we call a vertex decomposition V (G) = V1 ∪ · · · ∪ V` an H-decomposition, if G[Vi] ∈ H for 1 ≤ i ≤ `, where G[Vi] is a subgraph of G induced by Vi. In the following, we consider the case where G is a complete multipartite graph and H consists of graphs with a common number of vertices. Our aim is to find sufficient conditions for the existence of an H-decomposition having some nice properties. The next result was proved in [1].
Deposited poly-Si as on-demand linewidth compensator for on-chip Fabry–Perot interferometer and vertical linear variable optical filter bandpass and passband manipulation (2019)

Abstract Deep reactive ion etching (DRIE) is an important process for etching vertical structures for microelectromechanical systems. Due to the sidewall profile of some photoresists as well as effects from upstream processes, bulk micromachined structures, to a certain extent, could differ from expected. Concerning photonics applications, minute deviations from the intended design might alter its optical characteristics. The most popular approach is to introduce a compensation factor during mask design. However, such a method is not robust enough to accommodate batch variations due to varying process conditions. In one particular example specific to this work, the simulated passband for a Si-air Fabry–Perot interferometer configuration was 3.67 μ m. However, post DRIE the passband was measured to be 3.40 μ m. To resolve this discrepancy, linewidth compensation using low-pressure chemical vapor deposition (LPCVD) poly-Si is presented. When 170 and 194 nm of poly-Si were separately deposited, the passbands redshifted to 3.54 and 3.57 μ m, respectively. With the LPCVD poly-Si layer being highly conformable, the full width half maximum remains unchanged at 80 nm. An on-chip linear variable optical filter was demonstrated with a compensation of 194 nm poly-Si. It was observed that the working range redshifted from 3.0–3.9 μ m to 3.3–4.5 μ m.
A remote graphical display system (1969)

A system for the generation, transmission, local storage, and subsequent display of computer-generated arbitrary two-level pictures has been developed. It is capable of providing flicker-free displays without continuing expenditure of computer time. Users may interact with the display by means of a light-pen, tablet, etc., by adding a locally-generated cursor. The system is capable of serving approximately 120 remote consoles, if each requires a new picture every 20 seconds. The picture-quality is commensurate with that of high-quality closed-circuit television systems.
Low Contrast Dielectric Metasurface Optics (2016)

We demonstrate low contrast dielectric metasurface optical elements for operation at visible frequencies. Our devices show transmission efficiencies as high as 90% and focal spots on the order of the design wavelength.