gebhart/patrepeval huggingface dataset:
Utility of the Haemophilia Joint Health Score in study of episodically treated boys with severe haemophilia A and B in Lithuania (2010)

Musculoskeletal outcome remains the major hallmark of haemophilia. The purpose of the study was to assess joint status using a new musculoskeletal assessment tool in children with haemophilia and describe the development of haemophilic arthropathy during childhood and puberty focussing on the age of remarkable changes. The prospective study involved Lithuanian patients aged 4-17 years with severe haemophilia A and B, no signs of inhibitors and treatment on-demand. Patients were subdivided into two groups according to actual age. Group I patients were 4-9 years and group II patients 10-17 years of age. The musculoskeletal status was measured using the Haemophilia Joint Health Score (HJHS). We report on 20 patients with a mean age of 11.5 years (SD 4.3, range 4-17.2 years). The mean HJHS score was 24.5 (SD 14.5, range 5-50). The most affected joints were ankles, followed by knees and elbows. Mean HJHS score in age group I (n = 7) was 11.6 (SD 6.5); in group II (n = 13) the score was significantly higher - mean 31.5 (SD 12.8) (P = 0.0002). Ankles, knees and elbows were significantly more impaired based on the HJHS scores in older patients as compared with younger ones. The HJHS appears to be a useful tool in evaluating musculoskeletal outcome of patients receiving treatment on-demand. Children > or =10 years of age had significantly higher HJHS scores as a sign of progressing haemophilic arthropathy. We conclude that the most aggravating development of haemophilic joint damage seems to occur from the age of 10 and onwards.
On the Performance Gains of Cooperative Transmission Concepts in Intensity Modulated Direct Detection Visible Light Communication Networks (2010)

Visible light communication networks are currently constrained in range by the divergent source characteristics of the light emmiting diode (LED) and in achievable rate by the modulation bandwidth of the LED transmitter; however, as device advancements improve the limitation on rate becomes inter-symbol interference (ISI). The key contributor to ISI is the non-uniform time of arrival (TOA) of all light source transmissions. Data is conveyed using intensity modulation/direct detection, as such a time of arrival synchronization is not required of the light carrier, but rather of the baseband modulation sequence (data carrier). The concept of cooperative transmission is shown to improve achievable rate; however, communication range does not benefit as well in such networks. Cooperative transmission is a scheme in which a collection of transmission sources pool together their resources to send a commonly shared message in a manner that allows all data transmissions to arrive synchronously at the intended receiver. Although, LEDs emit incoherent light, it supposed that the a collection of LEDs can acheive time synchronization in its intensity modulated waveforms by altering the delays in which the LEDs change state. An elegant one-bit feedback procedure for RF beam-steering is adapted to acheive time of arrival synchronization of the data carrier over the visible light channel. It is assumed that all LED sources share the same clock; however, the sources and a user terminal do not. Data carrier clock synchronization between sources and a user terminal can be obtained using a Manchester line code or a mutual synchronization architecture to adapt to a master group of transmission sources fairly quickly. It is shown that cooperative transmit beamforming can lower the impact of ISI on in the visible light channel as device capability matures to require such an architecture.
[Local fibrinolysis of hypertensive intracerebral hematomas]. (2009)

Authors presented the results of experimental and clinical studies of effects of recombinant prourokinase on brain tissue, its toxicity and safety in intracerebral administration for lysis of hypertensive intracerebral hematomas. Experiments were performed in 64 rabbits. Histological specimens were examined in different periods after injection of prourokinase into white matter and into experimental hematoma. It is revealed that dose of 615 mg/kg causes minimal changes in cerebral tissue. Clinical study was based on analysis of puncture aspiration of intracerebral hematomas with local fibrinolysis performed in 275 patients with hemorrhagic stroke. Dynamics of MRI, clinical and laboratory parameters, coagulation, analysis of aspirated products of lysis were assessed. Authors showed that recombinant prourokinase and the drug "Puroplazan" are effective for local fibrinolysis. The drugs are non-toxic and non-allergenic and do not cause cerebral edema.
Resource Allocation with Interference Avoidance in OFDMA Femtocell Networks (2012)

Interference control and quality-of-service (QoS) awareness are the major challenges for resource management in orthogonal frequency-division multiple access femtocell networks. This paper investigates a self-organization strategy for physical resource block (PRB) allocation with QoS constraints to avoid the co-channel and co-tiered interference. Femtocell self-organization including self-configuration and self-optimization is proposed to manage the large femtocell networks. We formulate the optimization problem for PRB assignments where multiple QoS classes for different services can be supported, and interference between femtocells can be completely avoided. The proposed formulation pursues the maximization of PRB efficiency. A greedy algorithm is developed to solve the resource allocation formulation. In the simulations, the proposed approach is observed to increase the system throughput by over 13% without femtocell interference. Simulations also demonstrate that the rejection ratios of all QoS classes are low and mostly below 10%. Moreover, the proposed approach improves the PRB efficiency by over 82% in low-loading scenario and 13% in high-loading scenario.
Minimisation du temps total de traitement pour optimiser le fonctionnement d’un contrôleur de buffers pour les systèmes de vision embarquée (2017)

International audience
The Magnetospheric Cusp: Structure and Dynamics (2005)

Understanding the polar cusps is essential for a thorough understanding of the entire physics of the magnetosphere, and of the dynamical interaction between the solar wind and any planetary magnetosphere. Energetic electrons are unique to fully assess magnetic field-line topology and thus should be able to clearly delineate regions of open and closed magnetic field lines in the high-latitude regions and contributed crucially to understanding and resolving an internal debate going on between groups measuring only the lower energy (&lt; 20 keV) plasma. Energetic electrons with high and stable flux were observed in the high latitude boundary/cusp region when the Interplanetary Magnetic Field (IMF) had a predominate positive Bz component. With measurements at larger separations and more coordination of multiple satellite measurements for particular cusp crossings it will become more evident what the true nature of the cusp is and what roles the cusp plays. The boundary normal, velocity and timing analysis obtained by all four Cluster spacecraft indicates that the multiple cusp phenomena are most likely caused by the oscillation of a single northern cusp which was shifted back and forth. Cusp oscillations with a period of ∼20min are observed by Cluster in the high-latitude region, whilst the cold-dense plasma with fluctuations (20-min period) are observed in the dusk-side of the tail plasma sheet by Geotail. This is consistent with the idea that the high latitude reconnection during northward IMF is the responsible mechanism for the formation of the cold-dense plasma sheet.
How Pac-Man Eats (2020)

How the tools and concepts for making games are connected to what games can and do mean; with examples ranging from Papers, Please to Dys4ia. In How Pac-Man Eats, Noah Wardrip-Fruin considers two questions: What are the fundamental ways that games work? And how can games be about something? Wardrip-Fruin argues that the two issues are related. Bridging formalist and culturally engaged approaches, he shows how the tools and concepts for making games are connected to what games can and do mean. Wardrip-Fruin proposes that games work at a fundamental level on which their mechanics depend: operational logics. Games are about things because they use play to address topics; they do this through playable models (of which operational logics are the primary building blocks): larger structures used to represent what happens in a game world that relate meaningfully to a theme. Game creators can expand the expressiveness of games, Wardrip-Fruin explains, by expanding an operational logic. Pac-Man can eat, for example, because a game designer expanded the meaning of collision from hitting things to consuming them. Wardrip-Fruin describes strategies game creators use to expand what can be said through games, with examples drawn from indie games, art games, and research games that address themes ranging from border policy to gender transition. These include Papers, Please, which illustrates expansive uses of pattern matching; Prom Week, for which the game's developers created a model of social volition to enable richer relationships between characters; and Dys4ia, which demonstrates a design approach that supports game metaphors of high complexity.
Resticted Growth of Human Cytomegalovirus in UV-lrradiated WI-38 Human Fibroblasts (1975)

The growth of human CMV was inhibited by uv irradiation of cells prior to infection or during the 48-hr latent period of virus replication but not after virus synthesis began. The duration of uv exposure sufficient to inhibit CMV replication was insufficient to inhibit replication of Herpes simplex and did not prevent uninfected cells from dividing normally. The effect of uv irradiation on CMV replication may have been mediated through prevention of the virus on host cell RNA(s) synthesis.
In vitro hemolytic performance of the Realheart®V11C TAHprototype with porcine blood (2023)

The absolute and the relative hemolysis of the V11C are lower compared to both the large and small Reinheart TAH devices published values. Pulsatile pumps create more hemolysis in the Aachen rig, and it is not known if this is because how the rig handles pulsatile flow or due to the devices. Future studies will, therefore, use a pulsatile pump such as the SynCardia as clinical comparator and human blood to test the performance of future Realheart TAH prototypes.
Mesoporous cobalt phosphate electrocatalyst prepared using liquid crystal template for methanol oxidation reaction in alkaline solution (2018)

A crystalline mesoporous cobalt phosphate (meso-CoPi) electrocatalyst is prepared using liquid crystal template of non-ionic surfactant of Brij®78. The physicochemical investigations of the electrocatalyst executed by surface area analyzer, XRD, transmission electron microscope submits creation of a mesoporous crystalline nanostructured of meso-CoPi with a surface area of 124 m2 g−1. This is an 10-fold greatness superior than that for bulk-CoPi particles produced without surfactant template. The meso-CoPi electrocatalyst comprises of metallic cobalt layered with a cobalt-oxo/hydroxo-phosphate layer which facilitates the electro-oxidation of methanol at modest overpotential of < 1.2 V vs RHE in alkaline solution. The methanol oxidation activity of the meso-CoPi catalyst shows more than 20-fold current increase at 1.4 VRHE in comparison to bulk-CoPi counterpart which due to the enhancement of the electroactive specific surface area. Liquid crystal template chemical approach provides a reproducible stage to synthesize mesoporous metal phosphates with improved electrocatalytic activities.
Dissolution of CuS Particles with Fe(III) in Acidic Sulfate Solutions (2018)

The dissolution of CuS particles with Fe3+ in acidic sulfate solutions was investigated in an oxygen-free environment. CuS particles, used in this study, were obtained from H2S removal operations from biogas with an acidic CuSO4 solution in a Vitrisol pilot absorber. The CuS particles were porous with an average diameter of 5.8 × 10–6 m. Zero orders of reaction for both Fe3+ and H2SO4 were determined. Full conversion of CuS could be obtained independent of temperature. The activation energy was determined to be EA = 22.0 kJ/mol. It seems plausible that the CuS dissolution reaction was affected by diffusion.
A new route to the metastable FCC molybdenum carbide α-MoC1−x (2000)

The carburisation of a prereduced MoO3 provides a new method for the synthesis of the metastable α-MoC1−x.
Oral administrations of chemotherapeutics via the bioencapsulation technique: A tool for therapeutic treatment in larviculture (1996)

The application of the bioencapsulation technique as a tool for curative treatment in fish larvae was investigated. Antibacterials, trimethoprim (TMP) and sulphamethoxazole (SMX), incorporated in an oil emulsion (SELCO, Artemia Systems N.V., Ghent, Belgium) were bioencapsulated at different concentrations (20% and 40%) in Artemia (Instar II) nauplii. Chemotherapeutics-loaded nauplii were fed to European sea bass (Dicentrarchus labrax) larvae only once at 5 individuals/ml. Larvae were sampled after feeding at time intervals 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 12, 16, 20, 24, 36, 48, 60, 72 h. Drug concentrations in the larval tissue were analyzed by high-performance liquid chromatography (HPLC). Results indicated that larvae fed 40% "medicated"-Artemia assimilated significantly higher levels of chemotherapeutics in the tissue as compared with those fed 20% "medicated"-Artemia. Chemotherapeutics given at higher concentration (40%) reached peak levels (19.3 µg TMP/g DW, 23.32 µg SMX/g DW) in the larval tissues within 2 h while at lower concentration (20%) peak levels (8.74 µg TMP/g DW, 6.73 µg SMX/g DW) were observed within 5 h. Moreover, TMP persisted longer (&gt;72 h) in the tissues than SMX (12-16 h) suggesting a more efficient uptake and retention of TMP and/or faster metabolism and elimination of SMX.
Preparation of polymide‐imides by direct polycondensation with triphenyl phosphite. V. Aliphatic‐aromatic polyamide‐imides based on N,N′‐bis(ω‐carboxyalkyl) benzophenone‐3,3′,4,4′‐tetracarboxylic diimides (1991)

Abstract Five diimide‐dicarboxylic acids were prepared from benzophenone‐3,3′,4,4′‐tetracarboxylic dianhydride and glycine, β‐analine, 4‐aminobutyric acid, 6‐aminocaproic acid, and 11‐aminoundecanoic acid. New aromatic‐aliphatic polyamide‐imides were prepared by the direct polycondensation of these diacids with aromatic diamines using triphenyl phosphite in N ‐methyl‐2‐pyrrolidone (NMP)–Pyridine solution in the presence of calcium chloride. The resulting polymers were characterized by inherent viscosity, infrared spectra, elemental analyses, solubility, differential scanning calorimetry (DSC), thermogravimetry, and wideangle x‐ray diffraction measurements.
Potential Adult Neurogenesis in the Telencephalon and Cerebellar Cortex of the Nile Crocodile Revealed with Doublecortin Immunohistochemistry (2017)

The brain of the crocodile is known to gain in mass allometrically throughout life, and the addition of neurons (as well as non-neurons) appears to play a significant role in this increasing brain mass. We used immunohistochemistry in the brains of 12 Nile crocodiles ranging between 350 g and 86 kg in body mass and 1.99 g to 7.9 g in brain mass to identify the regions of the brain in which neurons immunopositive for doublecortin (DCX), a marker for potential adult neurogenesis, are found. Similar to other reptiles, potential newly born neurons, those immunopositive for DCX, were found throughout the telencephalon, the main and accessory olfactory bulbs and the olfactory tract, and in the cerebellar cortex; however, no DCX immunopositive neurons were observed in the diencephalon or brainstem. An apparent moderate decrease in the density of DCX labeled neurons in the olfactory bulbs and tract as well as the cerebellar cortex was observed with increasing brain mass, but the observed qualitative density of labeled neurons within the telencephalon was maintained irrespective of brain mass. Three potential neurogenic zones, within the sulci of the lateral ventricle, were identified, and these are similar to those seen in other reptiles. This study indicates that at least part of the gain in brain mass with age in the Nile crocodile may be accounted for by the potential addition and integration of new neurons into the existing circuitry, especially so for the olfactory system, telencephalon and cerebellar cortex. Anat Rec, 301:659-672, 2018. © 2017 Wiley Periodicals, Inc.
A technical guide to TRITEX, a computational pipeline for chromosome-scale sequence assembly of plant genomes (2022)

Even maximally contiguous sequence assemblies of the telomere-to-telomere sort, and to a yet greater extent, the fragmented kind require validation, correction, and comparison to reference standards. As pangenomics is burgeoning, these tasks are bound to become more widespread and TRITEX is one tool to get them done. This technical guide is supported by a step-by-step computational tutorial accessible under https://tritexassembly.bitbucket.io/ . The TRITEX source code is hosted under this URL: https://bitbucket.org/tritexassembly .
Multicore Off-Diagonal Magnetoimpedance Sensors Utilising Amorphous Wires (2015)

Abstract Magnetoimpedance (MI) sensors are attractive for realising a localised detection of weak magnetic fields owing to micro-size and high sensitivity of the MI elements based on Co-rich amorphous wires of diameter 10-30 microns. The MI sensors in off-diagonal configuration when the signal is taken from the coil mounted on the wire have a number of advantages including linearity, enhanced output voltage, and resonance detection circuitry. In this work, the off-diagonal impedance of a number of Co-rich glass-coated amorphous wires placed in the same coil is investigated. The wires are connected in parallel and excited by a harmonic current with optimised dc bias which is used to remove the domain structure. The best sensitivity of about 350 mV/Oe is obtained for two closely spaced wires at the excitation frequency of 20 MHz which corresponds to the resonance conditions for the detection circuit having only 55 turns. The full scale and linearity range are also increased almost twice in comparison with those when only one wire is used. The response drops if the distance between the wires is increased which is due to a strong effect of the magnetostatic interaction between the wires. We conclude that the off-diagonal MI sensors with multiple wires can provide higher transfer function per one turn and could be advantageous for localised field detection.
ROAR: A 3-D tethered rocket simulation code (1992)

A high-velocity impact testing technique, utilizing a tethered rocket, is being developed at Sandia National Laboratories. The technique involves tethering a rocket assembly to a pivot location and flying it in a semicircular trajectory to deliver the rocket and payload to an impact target location. Integral to developing this testing technique is the parallel development of accurate simulation models. An operational computer code, called ROAR (Rocket-on-a-Rope), has been developed to simulate the three-dimensional transient dynamic behavior of the tether and motor/payload assembly. This report presents a discussion of the parameters modeled, the governing set of equations, the through-time integration scheme, and the input required to set up a model. Also included is a sample problem and a comparison with experimental results.
Redundant In Vivo Proteolytic Activities of Escherichia coli Lon and the ClpYQ (HslUV) Protease (1999)

The ClpYQ (HslUV) ATP-dependent protease of Escherichia coli consists of an ATPase subunit closely related to the Clp ATPases and a protease component related to those found in the eukaryotic proteasome. We found that this protease has a substrate specificity overlapping that of the Lon protease, another ATP-dependent protease in which a single subunit contains both the proteolytic active site and the ATPase. Lon is responsible for the degradation of the cell division inhibitor SulA; lon mutants are UV sensitive, due to the stabilization of SulA. lon mutants are also mucoid, due to the stabilization of another Lon substrate, the positive regulator of capsule transcription, RcsA. The overproduction of ClpYQ suppresses both of these phenotypes, and the suppression of UV sensitivity is accompanied by a restoration of the rapid degradation of SulA. Inactivation of the chromosomal copy of clpY or clpQ leads to further stabilization of SulA in a lon mutant but not in lon+ cells. While either lon, lon clpY, or lon clpQ mutants are UV sensitive at low temperatures, at elevated temperatures the lon mutant loses its UV sensitivity, while the double mutants do not. Therefore, the degradation of SulA by ClpYQ at elevated temperatures is sufficient to lead to UV resistance. Thus, a protease with a structure and an active site different from those of Lon is capable of recognizing and degrading two different Lon substrates and appears to act as a backup for Lon under certain conditions.
Diffusion‐limited binding explains binary dose response for local arterial and tumour drug delivery (2009)

In this paradigm, drugs and antibodies with large B(p) penetrate faster and deeper into tissues when presented at high concentrations. Threshold dependence of tissue transport on applied surface concentration of paclitaxel and rapamycin may explain threshold dose dependence of in vivo biological efficacy of these drugs.
Novel Low k Dielectrics Based on Diamondlike Carbon Materials (1998)

Hydrogenated diamondlike carbon (DLC) and fluorine containing DLC (FDLC) were investigated for their potential applications as low k dielectrics for the back end of the line interconnect structures in ultralarge scale integrated circuits. It was found that the dielectric constant (k) of DLC can be varied between <2.7 and >3.4 by changing the deposition conditions. The thermal stability of the DLC films was found to be correlated to the values of the dielectric constant, decreasing with decreasing k. Only DLC films having dielectric constants k < 3.3 appeared to be stable to anneals of 4 h at 400°C in a nonoxidizing environment. However these films were characterized by stresses higher then 600 MPa. FDLC films, thermally more stable at 400°C than the DLC films with k > 3.3, could be prepared with dielectric constants below 2.7 and internal stresses <200 MPa. Such FDLC films are thus promising candidates as a low k interconnect dielectric.
Update of endoscopic classification system of adenoid hypertrophy based on clinical experience on 7621 children (2022)

These results can be useful to guide medical or surgical therapeutic intervention. In patients with class IIIB AH, surgical treatment offered adequate control not only of nasal symptoms but also of associated comorbidities.
Molecular dynamics studies on the thermostability of family 11 xylanases (2007)

Twelve members of the family 11 xylanases, including both mesophilic and thermophilic proteins, were studied using molecular dynamics (MD). Simulations of xylanases were carried out in an explicit water environment at four different temperatures, 300, 400, 500 and 600 K. A difference in thermotolerance between mesophilic and thermophilic xylanases became clear: thermophilic xylanases endured heat in higher simulation temperatures better than mesophilic ones. The unfolding pathways seemed to be similar for all simulations regardless of the protein. The unfolding initiates at the N-terminal region or alternatively from the alpha-helix region and proceeds to the 'finger region'. Unfolding of these regions led to denaturated structures within the 4.5 ns simulation at 600 K. The results are in agreement with experimental mutant studies. The results show clearly that the stability of the protein is not evenly distributed over the whole structure. The MD analysis suggests regions in the protein structure which are more unstable and thus potential targets for mutation experiments to improve thermostability.