gebhart/patrepeval huggingface dataset:
Study on Axial Oil Chamber Design for High Performance Hydrostatic Spindle (2014)

Ultra-precision machining and large-size equipments are the most primary development trend of current machine tool and hydrostatic products are key technologies of ultra-precision machining equipments. However, these equipments most ly process miniature components, thus the adopted tools are relatively small and the spindles are mainly built-in types of HSK32-HSK25 with over 30,000 r . Some processing equipments are even equipped with hydrostatic or gas-static spindles. The study extends the axial oil chamber to radial ones to expand the action area of axial oil pressure and form a closed oil seal edge by combining the radial clearance. Consequently, the axial bearing stiffness can be enhanced to enlarge the application scope of hydrostatic spindle. The design mode can enhance axial stiffness of spindle modules or strength en the stiffness of hydrostatic spindle in a ball screw.
Effect of Helium Pressure on the Response of Unirradiated UO2Subjected to Thermal Transients (1983)

The effect of helium pressure on the transient response of unirradiated depleted UO2 subjected to simulated hypothetical loss-of-flow accidents in a gas-cooled fast reactor was examined by use of the direct electrical heating technique. Transient tests were performed at pressures ranging from 7 to 10 × 105Pa (7 to 10 atm) to 7 to 8 MPa (70 to 80 atm) on radially restrained and unrestrained fuel segments. The average heating rates ranged from ∼17 to 240 J/g.s. The results indicate that while the mechanical integrity of the fuel segment was independent of the test pressure, the rapid ejection of molten fuel from pellet interfaces of unrestrained fuel, observed at the lower pressures, was delayed or suppressed at the higher pressures.
Water Chemistry (2010)

Carefully crafted to provide a comprehensive overview of the chemistry of water in the environment, Water Chemistry: Green Science and Technology of Nature's Most Renewable Resource examines water issues within the broad framework of sustainability, an issue of increasing importance as the demands of Earth's human population threaten to overwhelm t
Mechanistic insights into the catalytic elimination of tar and the promotional effect of boron on it: first-principles study using toluene as a model compound (2016)

The incorporation of a monolayer subsurface B into the Ni catalyst results in a corrugated Ni top surface and the activation of toluene is significantly promoted on B–Ni.
RELATIONS BETWEEN TWO SETS OF VARIATES (1936)

Journal Article RELATIONS BETWEEN TWO SETS OF VARIATES Get access HAROLD HOTELLING HAROLD HOTELLING Columbia University Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 28, Issue 3-4, December 1936, Pages 321–377, https://doi.org/10.1093/biomet/28.3-4.321 Published: 01 December 1936
An efficient MOS-capacitor based silicon modulator and CMOS drivers for optical transmitters (2014)

We present an efficient MOS-capacitor based silicon modulator. In an MZI configuration, a 9dB extinction ratio at 28 Gbps is achieved from the 1V output of a low-power CMOS inverter driver IC.
Tests of a protective shell passive release mechanism for hypersonic wind-tunnel models (1979)

A protective shell mechanism for wind tunnel models was developed and tested. The mechanism is passive in operation, reliable, and imposes no new structural design changes for wind tunnel models. Methods of predicting the release time and the measured loads associated with the release of the shell are given. The mechanism was tested in a series of wind tunnel tests to validate the removal process and measure the pressure loads on the model. The protective shell can be used for wind tunnel models that require a step input of heating and loading such as a thin skin heat transfer model. The mechanism may have other potential applications.
Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes (2023)

The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes. The canonical endoplasmic reticulum (ER) HLA class I assembly pathway enables presentation of cytosolic peptides, but effective intracellular surveillance requires multi-compartmental antigen sampling. Endo-lysosomes are generally sites of HLA class II assembly, but human monocytes and monocyte-derived dendritic cells (moDCs) also contain significant reserves of endo-lysosomal HLA class I molecules. We hypothesized variable influences of HLA class I polymorphisms upon outcomes of endo-lysosomal trafficking, as the stabilities and peptide occupancies of cell surface HLA class I molecules are variable. Consistent with this model, when the endo-lysosomal pH of moDCs is disrupted, HLA-B allotypes display varying propensities for reductions in surface expression, with HLA-B*08:01 or HLA-B*35:01 being among the most resistant or sensitive, respectively, among eight tested HLA-B allotypes. Perturbations of moDC endo-lysosomal pH result in accumulation of HLA-B*35:01 in LAMP1<sup>+</sup> compartments and increase HLA-B*35:01 peptide receptivity. These findings reveal the intersection of the vacuolar cross-presentation pathway with a constitutive assembly pathway for some HLA-B allotypes. Notably, cross-presentation of epitopes derived from two soluble antigens was also more efficient for B*35:01 compared to B*08:01, even when matched for T cell response sensitivity, and more affected by cathepsin inhibition. Thus, HLA class I polymorphisms dictate the degree of endo-lysosomal assembly, which can supplement ER assembly for constitutive HLA class I expression and increase the efficiency of cross-presentation.
Surgical anatomy, transperitoneal approach, and early postoperative complications of a ventral lumbar spine surgical model in Lewis rats. (2013)

Surgical models in animals are used extensively to study small molecules and devices for lumbar intervertebral disc repair, replacement, and fusion. Although the ventral lumbar animal models themselves are well described, critical assessment of morbidity and mortality avoidance when using the models have not been reported. Hypothesizing that technique modifications and the relative prevalence and severity of complications would be correlated, we collected and examined peri- and postoperative data stratified by surgical technique. We here report complications associated with the transperitoneal approach to the lumbar spine in 268 Lewis rats and offer data-driven suggestions regarding complication avoidance through technique modification. Compared with wider exposure, limiting the width of exposure to a maximum of 3 mm resulted in fewer neurologic complications in the lower limbs. In addition, avoiding extracorporeal reflection of the small intestine during the exposure was associated with lower incidence of postoperative gastrointestinal distress and fewer situations requiring euthanasia. These findings underscore the importance of detailed approaches in minimizing postoperative morbidity and attrition in surgical models.
Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme (1999)

Postoperative recovery after open colonic surgery may be accelerated by effective pain relief integrated into an accelerated rehabilitation programme.
Optimum soft-output detection for channels with intersymbol interference (1995)

In contrast to the conventional Viterbi algorithm (VA) which generates hard-outputs, an optimum soft-output algorithm (OSA) is derived under the constraint of fixed decision delay for detection of M-ary digital signals in the presence of intersymbol interference and additive white Gaussian noise. The OSA, a new type of the conventional symbol-by-symbol maximum a posteriori probability algorithm, requires only a forward recursion and the number of variables to be stored and recursively updated increases linearly, rather than exponentially, with the decision delay. Then, with little performance degradation, a suboptimum soft-output algorithm (SSA) is obtained by simplifying the OSA. The main computations in the SSA, as in the VA, are the add-compare-select operations. Simulation results of a convolutional-coded communication system are presented that demonstrate the superiority of the OSA and the SSA over the conventional VA when they are used as detectors. When the decision delay of the detectors equals the channel memory, a significant performance improvement is achieved with only a small increase in computational complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Efficient immunoaffinity chromatography of lymphocytes directly from whole blood (2018)

We show that defined lymphocytes can be rapidly purified by immunoaffinity chromatography starting directly from whole blood. The method relies on low-affinity Fab-fragments attached to a column-matrix combined with the reversible Strep-tag technology. Compared to established cell enrichment protocols, the Strep-tag affinity chromatography of cells is independent of erythrocyte lysis or centrifugation steps, allowing for simple cell-enrichment with good yields, high purities, and excellent functionality of purified cells.
Trajectories to Jupiter via gravity assists from Venus, Earth, and Mars (1998)

Gravity-assist trajectories to Jupiter, launching between 1999 and 2031, are identi ed using patched-conic techniques. The classical trajectories, such as the Venus–Earth–Earth gravity assist, and many less conventional paths, such as Venus–Mars–Venus–Earth, are examined. Flight times of up to about seven years are considered. The D V-optimized results con rm thatVenus–Earth–Earth is themosteffective gravity-assisttrajectory type,with launch opportunities occurring almost every year and launch vis viva for ballistic trajectories as low as 9 km2 /s2. If the Earth is excluded as a  yby body, Venus–Venus–Venus gravity assists are typically the best option,with launch vis viva for ballistic trajectories as low as 30 km2 /s2, although in some years nonconventionalpaths are better, such as a ballistic Venus–Mars–Venus–Venus trajectory in 2012, with a launch vis viva of 16 km2/s2 . Nonconventional paths, such as Venus–Mars–Venus–Earth with a 3.7-year  ight-time trajectory in 2021, can occasionally decrease the time of  ight signi cantly, at very minor D V cost, when compared with the classical types.
Clinical Effect of Cyclosporine 0.05% Eye Drops in Dry Eye Syndrome Patients (2008)

0.05% : (Cyclosporine 0
PREDICTION OF COMPLEX FLOW PATTERNS IN INTRACRANIAL ATHEROSCLEROTIC DISEASE USING COMPUTATIONAL FLUID DYNAMICS (2007)

Patient-based symptomatic ICAD lesions studied using CFD analysis appear to harbor a hemodynamically pathological environment that favors the activation, aggregation and distal embolization of platelets and is reversed by endovascular stent angioplasty.
Efficacy of water-based skin decontamination of occupational chemicals using in vitro human skin models: a systematic review (2021)

Percutaneous absorption of chemicals is a potential route of topical and systemic toxicity. Skin decontamination interrupts this process by removing contaminants from the skin surface. Decontamination using water-only or soap and water solutions is the current gold standard despite limited efficacy data. A summary of studies evaluating their efficacy in decontaminating occupational contaminants from <i>in vitro</i> human skin models is presented. Embase, MEDLINE, PubMed, Web of Science, and Google Scholar were searched for relevant articles and data extracted from 15 investigations that reported on 21 occupational contaminants, which were further classified as industrial chemicals, drugs, or pesticides. Water-only decontamination yielded no response in 4.3% (<i>n</i> = 6/140) and partial decontamination in 95.7% (<i>n</i> = 134/140) of skin samples. Soap and water decontamination yielded complete decontamination in 4.9% (<i>n</i> = 13/264) and partial decontamination in 95.1% (<i>n</i> = 251/264) of skin samples. Four studies (26.7%, <i>n</i> = 4/15) reported increased penetration rates or skin concentration of contaminants following decontamination, demonstrating a "wash-in" effect. Varying study methodologies hinder our ability to compare data and determine when water alone or soap and water are best used. International harmonized efficacy protocol might enhance our decontamination understanding and enable a more customized approach to decontamination clinical practice and research.
Collocation extraction based on syntactic parsing (2008)

Collocations (typical word associations like "to meet a condition", "to believe firmly", "highly controversial", "a deep concern") are pervasive in language. Due to their encoding idiomaticity, collocations are of paramount importance for text production tasks, for Foreign Language Learning as well as for Natural Language Processing applications such as machine translation. This thesis tackles the problem of automatic acquisition of collocations from text corpora, and proposes a methodological framework for their identification based on syntactic criteria. It is shown that (1) the results obtained are more reliable than those of standard methods based on linear proximity constraints, and (2) the syntax-based approach enables a more advanced treatment of these expressions, which is now largely absent in the related computational work: extraction of n-ary collocations (n&gt;2), induction of syntactic patterns for collocations, Web-based extraction of collocations, and translation of collocations.
Phorbol Ester Interferes with [3H]Norepinephrine Accumulation into Monolayers of PC 12 Cells by Stimulating the Release of Endogenous Norepinephrine (1990)

In this study we have observed an inhibition of the [3H]norepinephrine ([3H]NE) accumulation into rat phaeochromocytoma PC 12 cells by phorbol 12-myristate 13-acetate (PMA), whereas a biologically inactive phorbol ester was without effect. The inhibition was no longer observed when the PC 12 cells were preincubated with 10 microM reserpine, which inhibits the uptake of norepinephrine into the storage vesicles. This suggested a role of the intact vesicles in the inhibitory phenomenon. Subsequently we could show that PMA increased the efflux of [3H]NE from PC 12 cells in a dose dependent manner. It seemed likely, therefore, that the increased release of endogenous norepinephrine from PC 12 cells by the phorbol ester competed with exogenous [3H]NE for uptake by the plasma membrane NE (uptake1) carrier into the cells. Two observations were in agreement with such a model: (i) an increase in the external NE concentration decreased the effect of PMA on the [3H]NE uptake; and (ii) desensitization of the protein kinase C by long term treatment of the PC 12 cells with phorbol ester abolished the PMA effect on both [3H]NE efflux and [3H]NE uptake.
Identification of electronic traps in AlGaN/GaN HEMTs using UV light-assisted trapping analysis (2010)

UV light-assisted trapping analysis in conjunction with electroluminescence studies was employed to identify the location of traps generated in AlGaN/GaN HEMTs submitted to on-state stress. Our results indicate that UV light-assisted trapping is closely related to traps in the access region close to the gate edges. An increase in the dominant electronic trap density spatially located within the AlGaN layer underneath the gate and in the access region close to the drain side of the gate edge was found to be the most pronounced degradation mechanism for the stress conditions investigated. This trap level was found to be located 0.5 eV below the AlGaN conduction band.
A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance (2018)

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication fidelity, it is not clear why certain dNTP pool alterations are more mutagenic than others. As intracellular dNTP pools are mainly controlled by ribonucleotide reductase (RNR), and given the limited number of eukaryotic RNR mutations characterized so far, we screened for RNR1 mutations causing mutator phenotypes in Saccharomyces cerevisiae. We identified 24 rnr1 mutant alleles resulting in diverse mutator phenotypes linked in most cases to imbalanced dNTPs. Among the identified rnr1 alleles the strongest mutators presented a dNTP imbalance in which three out of the four dNTPs were elevated (dCTP, dTTP and dGTP), particularly if dGTP levels were highly increased. These rnr1 alleles caused growth defects/lethality in DNA replication fidelity-compromised backgrounds, and caused strong mutator phenotypes even in the presence of functional DNA polymerases and mismatch repair. In summary, this study pinpoints key residues that contribute to allosteric regulation of RNR's overall activity or substrate specificity. We propose a model that distinguishes between different dNTP pool alterations and provides a mechanistic explanation why certain dNTP imbalances are particularly detrimental.
Various methods available for detection of apoptotic cells- A review (2013)

Apoptosis is a process of programmed cell death occurring in multicellular organisms in whom development, maintenance and sculpturing organs and tissues. Taken together, apoptotic processes are of widespread biological significance; being involved in e.g. development, differentiation, proliferation/homoeostasis, regulation and function of the immune system and in the removal of defected harmful cells. Dys regulation of apoptosis can play a primary or secondary role leading to cancer whereas excessive apoptosis contributes to neuro degeneration, autoimmunity, AIDS, and ischemia. Gaining insight into the techniques for detecting apoptotic cells will allow the development of more effective, higher specific and therefore better-tolerable therapeutic approaches. The goal of this review article is to provide a general overview of current knowledge, on the various technical approaches for detecting apoptotic cells.
Unexpected Coupling Reaction of 9-Lithiobromomethylene-9H-fluorene with 6,6-Dicyclopropylfulvene (1997)

Metallation of 9-bis(bromomethylene)-9H-fluorene with one equivalent of BuLi at -78°C followed by qhenching with 6,6-dicyclopropylfulvene and subsequent warming (room temperature, 18 h) gave an adduct identified as compound 5 (∼70% yield). Under identical conditions dimethylfulvene and cyclopropylmethylfulvene failed to give a similar adduct. Simple and efficient synthesis of 9-bromomethylene- and 9-bis(bromomethylene)-9H-fluorene are also described.
A New Species ofOonopsTempleton, 1835, (Araneae: Oonopidae) from the Gavarres, Baix Empordà, Catalonia (2017)

Oonops gavarrensis n. sp. is described from the Gavarres protected natural area in Catalonia, Spain. The new species is related to Oonops procerus Simon, 1882. It was encountered in soil litter and under stones.
Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: A randomized, double-blind study (2012)

This pilot study suggests that LCR35 could have some efficacy in IBS patients complaining of diarrhoea. These preliminary results need to be confirmed in larger studies.
Fatigue Crack Arrest in Mild Steel via Iron Electroplating (2021)

In this work, electrochemical plating treatments were applied to ASTM A36 steel specimens to study the efficiency and limitations of this method for arresting fatigue crack propagation. Electroplated iron was deposited onto the crack surfaces using a circuit in which Swedish Iron served as the anode in a solution of Ammonium Iron(II) Sulfate Hexahydrate. The iron ions were driven into fatigue cracks that were formed within ASTM E399 compact tension specimens. This work showed that an iron-plating treatment operated at 20°C can arrest fatigue crack propagation for a significant period of cycles. The propagation re-initiation lives that resulted ranged from 11,000 to 230,000 cycles. As observed in prior work, the propagation re-initiation life correlated strongly to the magnitude of the stress intensity factor range that was applied during cycling. As this stress intensity increased, the propagation re-initiation life decreased. Repeated treatments on the same crack provided extended service lives by as much as 370,000 cycles or 60% of the entire fatigue life of the component. Future work may show that re-application of the treatment, when conducted prior to crack re-initiation, could further extend the service life indefinitely. The Correia crack closure model was modified to provide an empirical expression for predicting the crack re-initiation life of the treated component. Interestingly, highly effective arrest behavior was still observed for cracks that were loaded to stress intensity factors of only 3 - 6 during the treatment but then subjected to 20 during cyclic loading. Galvanic corrosion of the plated material exposed to simulated seawater was estimated to be 3 mpy. Future work will examine the use of less active plating alloys and the possibility of applying effective treatments into cracks that are in an unloaded state.
Data from Identification of Deleterious <i>NOTCH</i> Mutation as Novel Predictor to Efficacious Immunotherapy in NSCLC (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;NOTCH signaling is associated with tumorigenesis, mutagenesis, and immune tolerance in non–small cell lung cancer (NSCLC), indicating its association with the clinical benefit of immune checkpoint inhibitors (ICI). We hypothesized that &lt;i&gt;NOTCH&lt;/i&gt; mutation in NSCLC might be a robust predictor of immunotherapeutic efficacy.&lt;/p&gt;Experimental Design:&lt;p&gt;Multiple-dimensional data including genomic, transcriptomic, and clinical data from cohorts of NSCLC internal and public cohorts involving immunotherapeutic patients were analyzed. Polymorphism Phenotyping v2 (PolyPhen-2) system was performed to determine deleterious &lt;i&gt;NOTCH&lt;/i&gt; mutation (del-&lt;i&gt;NOTCH&lt;/i&gt;&lt;sup&gt;mut&lt;/sup&gt;). Further investigation on molecular mechanism was performed in The Cancer Genome Atlas (TCGA) data via CIBERSORT and gene set enrichment analysis.&lt;/p&gt;Results:&lt;p&gt;Our 3DMed cohort (&lt;i&gt;n&lt;/i&gt; = 58) and other four cohorts (Rizvi, POPLAR/OAK, Van Allen, and MSKCC; &lt;i&gt;n&lt;/i&gt; = 1,499) uncovered marked correlation between &lt;i&gt;NOTCH1/2/3&lt;/i&gt; mutation and better ICI outcomes in &lt;i&gt;EGFR/ALK&lt;/i&gt;&lt;sup&gt;WT&lt;/sup&gt; population, including objective response rate (2.20-fold, &lt;i&gt;P&lt;/i&gt; = 0.001), progression-free survival [HR, 0.61; 95% confidence interval (CI), 0.46–0.81; &lt;i&gt;P&lt;/i&gt; = 0.001], and overall survival (HR, 0.56; 95% CI, 0.32–0.96; &lt;i&gt;P&lt;/i&gt; = 0.035). Del-&lt;i&gt;NOTCH&lt;/i&gt;&lt;sup&gt;mut&lt;/sup&gt; exhibited better predictive function than non-deleterious &lt;i&gt;NOTCH&lt;/i&gt; mutation, potentially via greater transcription of genes related to DNA damage response and immune activation. Del-&lt;i&gt;NOTCH&lt;/i&gt;&lt;sup&gt;mut&lt;/sup&gt; was not linked with prognosis in TCGA cohorts and chemotherapeutic response, but was independently associated with immunotherapeutic benefit, delineating the predictive, but not prognostic, utility of del-&lt;i&gt;NOTCH&lt;/i&gt;&lt;sup&gt;mut&lt;/sup&gt;.&lt;/p&gt;Conclusions:&lt;p&gt;This work distinguishes del-&lt;i&gt;NOTCH&lt;/i&gt;&lt;sup&gt;mut&lt;/sup&gt; as a potential predictor to favorable ICI response in NSCLC, highlighting the importance of genomic profiling in immunotherapy. More importantly, our results unravel a possibility of personalized combination immunotherapy as adding NOTCH inhibitor to ICI regimen in NSCLC, for the optimization of ICI treatment in clinical practice.&lt;/p&gt;&lt;/div&gt;