gebhart/patrepeval huggingface dataset:
External impedance and admittance of buried horizontal wires for transient studies using transmission line analysis (2007)

The paper investigates the applicability of some closed form expressions for the ground impedance and ground admittance of buried horizontal wires (bare and insulated) for lightning or switching transient analyses based on transmission line (TL) theory. In view of the frequency contents that typically characterize such transients, the behavior of the ground impedance and admittance is studied for a wide frequency range up to 10 MHz. Low frequency approximation of the ground impedance is not always appropriate for transient analysis. Sensitivity analyses show that, unlike overhead wires, the ground impedance for buried wires is little sensitive to the ground conductivity. On the other hand, the ground admittance varies strongly with the ground conductivity. The paper also discusses the results of transient analysis of buried cables performed by means of electromagnetic transient programs (EMTP) that neglect the ground admittance. The limits of such an approximation are discussed in order to evaluate the applicability of EMTP-like programs to the transient analysis of buried conductors. Transient pulse propagation in time domain based on finite difference time domain (FDTD) method of solution of TL equations is also discussed for a future inclusion of non-linear phenomena, like soil ionization and arcing/breakdown mechanisms, in the soil. The analysis presented could be useful in estimating surge propagation characteristics of buried wires for appropriate insulation coordination and transient protection.
How Individual Can Personalized Antiretroviral Treatment Be? Deep Salvage in an HIV-1-Infected Patient (2012)

We present an HIV-1-infected male (who is now 52 years old) with a multi-drug-resistant virus and discuss the considerations finally leading to an antiretroviral regimen resulting in long-term viral suppression and excellent immunological response in a deep salvage situation. Even in a desperate situation with high-level multi-class resistance, highly individual, personalized antiretroviral regimes can be tailor-made to achieve unexpected improvements in the health status of a patient.
An Analytical Framework for Throughput Analysis of Real Time Applications in All-IP Networks (2017)

Guaranteeing the quality of service (QoS) for real time applications is one of the challenging issues in next generation all-IP networks. Analysing the user perceived throughput is essential to measure the QoS experienced by real time applications. Medium access control (MAC) mechanism of the serving access network as well as the vertical handover (VHO) algorithm used by the mobile terminals (MTs) for target network selection have significant impact on user perceived throughput. Apart from that the upper layer mobility management protocol also influences the throughput performance considerably. The existing frameworks for throughput analysis do not adequately address the MAC specific issues. In this work, we have developed an analytical framework to analyse user perceived throughput considering the effect of both MAC specific details and upper layer mobility management protocol. Using our proposed framework, we have compared the throughput performance of video traffic application when mobile IPv6 (MIPv6) and seamless IP diversity based generalized mobility architecture (SIGMA) are used for mobility management. Our analysis reveals that the superiority of SIGMA over MIPv6 is actually conditional on the performance of the underlying VHO algorithm. Extensive simulations have been done to validate the analytical results.
In situ hybridization detection of varicella zoster virus in paraffin-embedded skin biopsy samples (1996)

This in situ hybridization technique is a sensitive and specific method for the diagnosis of VZV in skin lesions that is applicable to most histopathology laboratory settings. In addition, in situ hybridization reveals individual infected cells and may provide insight into the pathogenesis of VZV skin infection.
Human IAPP is a contributor to painful diabetic peripheral neuropathy (2023)

Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. hIAPP-transgenic mice, which have elevated plasma hIAPP levels without hyperglycemia, developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice, which have hyperglycemia in combination with elevated plasma hIAPP levels, had signs of neuropathy, although more aggravated. In wild-type mice, intraplantar and intravenous hIAPP injections induced long-lasting allodynia and decreased IENF density. Non-aggregating murine IAPP, mutated hIAPP (pramlintide), or hIAPP with pharmacologically inhibited aggregation did not induce these effects. T2DM patients had reduced IENF density and more hIAPP oligomers in the skin compared with non-T2DM controls. Thus, we provide evidence that hIAPP aggregation is neurotoxic and mediates peripheral neuropathy in mice. The increased abundance of hIAPP aggregates in the skin of T2DM patients supports the notion that hIAPP is a potential contributor to T2DM neuropathy in humans.
Detection of echoes using time-frequency analysis techniques (1996)

The following is a presentation of echo detection techniques based on time-frequency signal analysis for the measuring of thickness in thin multilayer structures. These techniques are shown to provide high-resolution signal characterization in a time-frequency space, and good noise rejection performance. In particular, the short-time Fourier transform, the Gabor expansion, the cross-ambiguity function and the Wigner-Ville distribution are analyzed and compared with techniques such as the logarithmic power spectrum, cepstrum and the segmented chirp Z-Transform. A suitable operating procedure was set up, based on an initial emulation phase in which simulated signals were considered, followed by a second phase in which real signals were processed. The results show the optimum performances of these new techniques compared with the traditional ones and, in particular, that the accurate measurement of thickness can be obtained also when waveform transients partially overlap.
User manual for AQUASTOR: a computer model for cost analysis of aquifer thermal-energy storage oupled with district-heating or cooling systems. Volume II. Appendices (1982)

A computer model called AQUASTOR was developed for calculating the cost of district heating (cooling) using thermal energy supplied by an aquifer thermal energy storage (ATES) system. the AQUASTOR Model can simulate ATES district heating systems using stored hot water or ATES district cooling systems using stored chilled water. AQUASTOR simulates the complete ATES district heating (cooling) system, which consists of two prinicpal parts: the ATES supply system and the district heating (cooling) distribution system. The supply system submodel calculates the life-cycle cost of thermal energy supplied to the distribution system by simulating the technical design and cash flows for the exploration, development, and operation of the ATES supply system. The distribution system submodel calculates the life-cycle cost of heat (chill) delivered by the distribution system to the end-users by simulating the technical design and cash flows for the construction and operation of the distribution system. The model combines the technical characteristics of the supply system and the technical characteristics of the distribution system with financial and tax conditions for the entities operating the two systems into one techno-economic model. This provides the flexibility to individually or collectively evaluate the impact of different economic and technical parameters, assumptions, and uncertainties on the cost of providing district heating (cooling) with an ATES system. This volume contains all the appendices, including supply and distribution system cost equations and models, descriptions of predefined residential districts, key equations for the cooling degree-hour methodology, a listing of the sample case output, and appendix H, which contains the indices for supply input parameters, distribution input parameters, and AQUASTOR subroutines.
Development of a shape memory based air conditioning system (2017)

The following contribution presents a new concept of an air conditioning device based on the elastocaloric cooling effect of shape memory alloys (SMA’s). This technology provides an energy efficient and environment friendly alternative to conventional vapor compression based cooling principles. Starting from the thermodynamic investigation of the elastocaloric cooling process, a continuous operating elastocaloric air cooling device is developed. The device enables an optimized thermodynamic process control under various operating conditions as well as large temperature spans. This work presents the design process of such a system starting from SMA based heat engines to a thermodynamically optimized design of an elastocaloric air conditioning device.
Effects on Corticospinal Tract Homology of Faremus Personalized Neuromodulation Relieving Fatigue in Multiple Sclerosis: A Proof-of-Concept Study (2023)

The Faremus-related CST changes extend the relevance of the balance between hemispheric homologs to the homology between body sides. With this work, we contribute to the development of new network-sensitive measures that can provide new insights into the mechanisms of neuronal functional patterning underlying relevant symptoms.
Nitric Oxide Production Following Irradiation of Tumor and Murine Hematopoietic Progenitor Cells in Vitro (2008)

Ionizing radiation turns on mitochondrial nitric oxide synthase (mtNOS) resulting in increased nitric oxide (NO), superoxide (O 2 − ) and, as a consequence, damaging peroxynitrite (ONO 2 − ) formation. In studies of normal irradiated tissues (e.g., urinary bladder) the mitochondrial targeting of NOS antagonists was more radioprotective than manganese superoxide dismutase (MnSOD) overexpression. NOS antagonists prevent both NO and O 2 − production, whereas dismutation of O 2 − results in hydrogen peroxide (H 2 O 2 ) formation which must be cleared by glutathione peroxidase (GPX) or catalase. Irradiation (5 Gy) of 32D cl 3 murine hematopoietic progenitor cells resulted in a significant increase of NO production (from 0.9±0.4 to 3.4±1.0 μM NO/10 6 cells) but not in Lewis Lung Carcinoma (3LL) or human head and neck cancer Cal33 cells. Overexpression of MnSOD in nonirradiated 32D and 3LL cells resulted in higher levels of NO even in comparison to irradiated 32D and 3LL cells. Irradiation did not further augment NO levels in 32D or 3LL cells overexpressing MnSOD. However, NO production in Cal33 control and MnSOD overexpressing cells was low before irradiation (0.4±0.1 and 0.52±0.02 μM NO/10 6 cells, respectively), but increased significantly in MnSOD overexpressing cells after irradiation (2.1 μM NO/10 6 cells). Future studies will investigate the role of NOS antagonists in radiation protection. Funded by NIH DK071085.
Starch (2002)

Abstract Introduction and Historical Perspective Occurrence, Sources and Production Morphology and Composition of the Starch Granule Morphology Polysaccharides Lipids Proteins Minerals Biosynthesis and Granule Deposition Biosynthesis Granule Deposition The Structure of Starch Granules Major Features of the Granule Crystallinity Architecture of the Granule Physical Properties Microscopy of Starch Granules Gelatinization and Swelling Rheological Properties of Starch Helical Complexes of Amylose Retrogradation of Starch Resistant Starch Modification of Starch Properties The Need for Modification Analysis of Starch Early Methods of Determination of Starch Quantitative Enzymatic Methods Industrial Production of Starch General Principles Uses of Starch Hydrolysis Products of Starch Introduction Other Products of Hydrolysis Uses of Hydrolyzed Products Concluding Remarks
Microsoft PPP CHAP Extensions, Version 2 (2000)

The Point-to-Point Protocol (PPP) [1] provides a standard method for
transporting multi-protocol datagrams over point-to-point links. PPP
defines an extensible Link Control Protocol and a family of Network
Control Protocols (NCPs) for establishing and configuring different
network-layer protocols. This document describes version two of
Microsoft's PPP CHAP dialect (MS-CHAP-V2). MS-CHAP-V2 is similar
to, but incompatible with, MS- CHAP version one (MS-CHAP-V1, described
in [9]). In particular, certain protocol fields have been deleted or
reused but with different semantics. In addition, MS-CHAP-V2 features
mutual authentication. The algorithms used in the generation of
various MS-CHAP-V2 protocol fields are described in section 8.
Negotiation and hash generation examples are provided in section 9.
Rapid Genomic Change in Higher Plants (1985)

INTR ODUCTI ON 367 EXAMPLES OF RAPID OR PR OGRAMMED GENOMIC CHANGE 368 Chromosome Rearrangements 368 Chromosome Imprint ing 370 Gene Ampli ficat ion and Loss 370 Transposable Elements 372 LIFE HIST ORY DIFFERENCES BE TWEEN HIGHER PLANTS AND ANIMALS.... 374 PHENO TYPIC AND GENO TYPIC PLASTICITY IN HIGHER PLANTS 377 Plastid Genome ...... 377 Mitochondrial Genome 378 Nuclear Genome 380 C ONCLUDING REMARKS 391
An excellent rechargeable PP14TFSI ionic liquid dual-ion battery (2017)

An ionic liquid dual-ion battery with pure 1-butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide as the electrolyte was developed, which exhibited a high discharge plateau initiated at 4.4 V, a well-defined capacity of 82 mA h g<sup>-1</sup>, an ultrawide charge/discharge potential range of 1.0-5.0 V and a superior stability of ∼100% capacity retention for 600 cycles.
Ultrafast carrier trapping in oxygen-doped metal-organic vapor phase epitaxy GaAs (1997)

We have experimentally investigated the ultrafast carrier dynamics in GaAs grown by metal-organic vapor phase epitaxy with an oxygen precursor. Using a time-resolved reflection ellipsometric technique, we measured the carrier-induced refractive and absorptive index changes as a function of oxygen and aluminum doping concentrations. The free carrier trapping time is inversely proportional to the aluminum-oxygen based complex concentration and can be as short as 300 fs. The material is also highly resistive and promises to be an excellent candidate for optoelectronic applications requiring short carrier lifetime and high dark isolation.
Silver and Palladium Complexes Containing Ditopic N-Heterocyclic Carbene–Thione Ligands (2012)

The mixed donor N-heterocyclic carbene (NHC)/thione ligand precursors [1-(3-R-2H-imidazol-1-yl-2-thione)methyl-3-R-2H-imidazol-2-ium]X, [HCSR]X (R = methyl, benzyl; X = Br, I), have been utilized to prepare a range of silver and palladium complexes. The coordination of CSR to silver(I) salts has been explored, providing dimeric complexes of the type [AgX(CSR)]2 (where R = methyl, benzyl; X = Br, I). Structural characterization of [AgX(CSBn)]2 revealed a bidentate coordination mode for the mixed donor ligand and dinuclear structures where the silver centers are bridged by two bromido centers. Palladium complexes bearing one or two CSR ligands have additionally been prepared either directly, utilizing [Pd(OAc)2] as precursor, or via transmetalation strategies. The dicationic complexes [Pd(CSR)2][X]2 and neutral complexes [PdX2(CSR)] (where R = methyl, benzyl; X = Br, I, PF6) have been synthesized and fully characterized. The CSR ligand in the aforementioned complexes does not undergo transformation of the NHC unit to a urea function, which had been found to occur in the previously reported copper complexes. Palladium complexes containing both NHC/thione and bis-phosphine ligands were also prepared. Complexes of the type [Pd(CSMe)(L2)][X]2 and [PdX(CSMe)(L2)][X] (where L2 = dppe, dppp; X = Br, OAc, I, PF6) were obtained. The presence of the bis-phosphine appears to destabilize the coordination of the NHC/thione ligand and as a consequence leads to its elimination from the complex.
Data from Quadruple-Negative GIST Is a Sentinel for Unrecognized Neurofibromatosis Type 1 Syndrome (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The majority of gastrointestinal stromal tumors (GIST) are driven by &lt;i&gt;KIT, PDGFRA&lt;/i&gt;, or, less commonly, &lt;i&gt;BRAF&lt;/i&gt; mutations, and &lt;i&gt;SDH&lt;/i&gt; gene inactivation is involved in a limited fraction of gastric lesions. However, about 10% of GISTs are devoid of any of such alterations and are poorly responsive to standard treatments. This study aims to shed light on the molecular drivers of quadruple-negative GISTs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Twenty-two sporadic quadruple-negative GISTs with no prior association with Neurofibromatosis Type 1 syndrome were molecularly profiled for a panel of genes belonging to tyrosine kinase pathways or previously implicated in GISTs. For comparison purposes, 24 GISTs carrying &lt;i&gt;KIT, PDGFRA&lt;/i&gt;, or &lt;i&gt;SDH&lt;/i&gt; gene mutations were also analyzed. Molecular findings were correlated to clinicopathologic features.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Most quadruple-negative GISTs featured intestinal localization, with a female predilection. About 60% (13/22) of quadruple-negative tumors carried &lt;i&gt;NF1&lt;/i&gt; pathogenic mutations, often associated with biallelic inactivation. The analysis of normal tissues, available in 11 cases, indicated the constitutional nature of the &lt;i&gt;NF1&lt;/i&gt; mutation in 7 of 11 cases, unveiling an unrecognized Neurofibromatosis Type 1 syndromic condition. Multifocality and a multinodular pattern of growth were common findings in &lt;i&gt;NF1&lt;/i&gt;-mutated quadruple-negative GISTs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt;&lt;i&gt;NF1&lt;/i&gt; gene mutations are frequent in quadruple-negative GISTs and are often constitutional, indicating that a significant fraction of patients with apparently sporadic quadruple-negative GISTs are affected by unrecognized Neurofibromatosis Type 1 syndrome. Hence, a diagnosis of quadruple-negative GIST, especially if multifocal or with a multinodular growth pattern and a nongastric location, should alert the clinician to a possible Neurofibromatosis Type 1 syndromic condition. &lt;i&gt;Clin Cancer Res; 23(1); 273–82. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Porous silicon and siloxene: Vibrational and structural properties (1993)

Using Raman and infrared transmission spectroscopy, the vibrational properties of siloxene (${\mathrm{Si}}_{6}$${\mathrm{O}}_{3}$${\mathrm{H}}_{6}$) and its derivatives are investigated and interpreted in terms of various structural modifications of siloxene which have been proposed in the past. On the basis of experimental and theoretical investigations siloxene is found to be a mixture of ${\mathrm{Si}}_{6}$ rings and/or linear Si chains interconnected by oxygen, and Si planes terminated by H and OH. The influence of thermal annealing, chemical treatment, and laser irradiation on the structure of siloxene is discussed in terms of the corresponding changes of the vibrational spectra and the x-ray-diffraction patterns. The vibrational properties of siloxene are very similar to those of electrochemically anodized porous Si. Raman, infrared transmission, and photoluminescence measurements of the two classes of materials are compared and a possible mechanism for the efficient luminescence in porous Si is discussed in light of the similarities between siloxene and porous Si.
Supplementary Data from A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of <i>BRAF</i>-mutated Melanoma to MAPK Inhibitors (2023)

&lt;p&gt;Contains Supplementary materials and methods, Supplementary Figures S1-S9, Table S2, Table S4, Supplemental References Figure S1, related to Figure 1. Cell surface marker screening of A375P cells treated with vehicle (DMSO) or PLX. Figure S2, related to Figure 1. CD36 is a biomarker of the early stage of MAPK inhibition in melanoma. Figure S3, related to Figure 1. MAPK inhibition induces and maintains the CD36+ population in melanoma cells Figure S4, related to Figure 2. MAPKi induce the expression of genes involved in lipid catabolism in BRAFV600E melanomas. Figure S5, related to Figure 3. MAPK inhibition decreased the glycolytic flux in BRAF-mutated melanoma cells. Figure S6, related to Figure 4. Phenotypic and metabolic characterization of CD36 WT, CD36 KO, CD36+ and CD36- A375P cells. Figure S7, related to Figure 5. PPARα does not regulate CD36 expression. Figure S8, related to Figure 6. Role of glycolysis and FAO inhibitors in proliferation and resistance to MAPKi Figure S9, related to Figure 6. Effects of MAPK, glycolysis and FAO inhibition on mouse and tumor weight. Table S2, related to Figure 1, Figure 3, Figure 6, Figure S3 and Figure S6. Primer list. Table S4, related to Figure 1 and Figure S2. Cell lines, their mutational status and their responsiveness to MAPK inhibitors.&lt;/p&gt;
Accelerating critical section execution with asymmetric multi-core architectures (2009)

To improve the performance of a single application on Chip Multiprocessors (CMPs), the application must be split into threads which execute concurrently on multiple cores. In multi-threaded applications, critical sections are used to ensure that only one thread accesses shared data at any given time. Critical sections can serialize the execution of threads, which significantly reduces performance and scalability. This paper proposes Accelerated Critical Sections (ACS), a technique that leverages the high-performance core(s) of an Asymmetric Chip Multiprocessor (ACMP) to accelerate the execution of critical sections. In ACS, selected critical sections are executed by a high-performance core, which can execute the critical section faster than the other, smaller cores. As a result, ACS reduces serialization: it lowers the likelihood of threads waiting for a critical section to finish. Our evaluation on a set of 12 critical-section-intensive workloads shows that ACS reduces the average execution time by 34% compared to an equal-area 32T-core symmetric CMP and by 23% compared to an equal-area ACMP. Moreover, for 7 out of the 12 workloads, ACS improves scalability by increasing the number of threads at which performance saturates.
Conception et réalisation d'un micro-filtre accordable de type Fabry-Perot intégré sur silicium (2000)

Le but de cette thèse est la conception, la fabrication et la caractérisation de micro-filtres spectraux accordables, de type "Fabry-Perot", intégrés sur silicium. Ces composants sont utilisés pour deux types d'applications présentés au chapitre I : l'analyse de gaz et les télécommunications optiques. Afin de répondre aux spécifications de cette dernière application, très contraignante en terme de sélectivité, nous proposons l'utilisation d'une cavité optique de grande épaisseur, comportant deux miroirs de forte réflectivité dont l'un est rendu mobile grâce à un actionnement de type électrostatique. Le chapitre II présente les concepts théoriques (en optique, micromécanique et électrostatique) utilisés pour le dimensionnement des composants et l'analyse de leurs caractéristiques opto-mécaniques. Dans le chapitre III, on s'intéresse à la fabrication des filtres Fabry-Perot. La principale difficulté a consisté à réaliser des miroirs mobiles obtenus par adhésion moléculaire...
Surgical management of negative dysphotopsia (2018)

Negative dysphotopsia was associated with acrylic or silicone IOLs of either square- or round-edge design. Negative dysphotopsia was reduced, eliminated, or prevented when the IOL optic overlaid the anterior capsulotomy rather than when the capsule edge overlaid the optic. Bag-to-sulcus IOL exchange and reverse optic capture were highly successful in managing or preventing negative dysphotopsia.