gebhart/patrepeval huggingface dataset:
Avian Bornaviruses in Wild Aquatic Birds of the Anseriformes Order in Poland (2022)

Bornaviruses are a diverse family of viruses infecting various hosts, including birds. Aquatic bird bornavirus 1 (ABBV-1) and aquatic bird bornavirus 2 (ABBV-2) have been found in wild waterfowl but data on their prevalence are scarce. To gain knowledge on the occurrence of ABBVs in Poland, samples originating from dead birds of the Anseriformes order collected in 2016-2021 were tested with a real time RT-PCR method targeting the ABBVs genome. A total of 514 birds were examined, including 401 swans, 96 ducks and 17 geese. The presence of ABBV-1 RNA was detected in 52 swans (10.1% of all tested birds) from 40 different locations. No positive results were obtained for ducks and geese. Sequences of about 2300 bases were generated for 18 viruses and phylogenetic analysis was performed. A relatively low genetic diversity of the examined ABBV-1 strains was observed as all were gathered in a single cluster in the phylogenetic tree and the minimum nucleotide identity was 99.14%. The Polish strains were closely related to ABBV-1 identified previously in Denmark and Germany, but a limited number of sequences from Europe hinders the drawing of conclusions about interconnections between Polish and other European ABBVs. The results of the present study provide new insights into the distribution and genetic characteristics of ABBVs in wild birds in Europe.
Use of a probabilistic shape model for non-linear registration of 3D scattered data (2002)

In this paper we address the problem of registering 3D scattered data by the mean of a statistical shape model. This model is built from a training set on which a principal component analysis (PCA) is applied. A local system of reference is computed for each sample shape of the learning set, which enables to align the training set. PCA then reveals the main modes of deformation of the class of objects of interest. Furthermore, the deformation field obtained between a given shape and a reference shape is extended to a local neighborhood of these shapes by using an interpolation based on the thin-plate splines. It is then used to register objects associated with these shapes in a local and non-linear way. The data involved here are cerebral data, both anatomical (cortical sulci) and functional (MEG dipoles).
Graph-based ranking algorithms for sentence extraction, applied to text summarization (2004)

This paper presents an innovative unsupervised method for automatic sentence extraction using graph-based ranking algorithms. We evaluate the method in the context of a text summarization task, and show that the results obtained compare favorably with previously published results on established benchmarks.
Bayesian geometric modeling of indoor scenes (2012)

We propose a method for understanding the 3D geometry of indoor environments (e.g. bedrooms, kitchens) while simultaneously identifying objects in the scene (e.g. beds, couches, doors). We focus on how modeling the geometry and location of specific objects is helpful for indoor scene understanding. For example, beds are shorter than they are wide, and are more likely to be in the center of the room than cabinets, which are tall and narrow. We use a generative statistical model that integrates a camera model, an enclosing room “box”, frames (windows, doors, pictures), and objects (beds, tables, couches, cabinets), each with their own prior on size, relative dimensions, and locations. We fit the parameters of this complex, multi-dimensional statistical model using an MCMC sampling approach that combines discrete changes (e.g, adding a bed), and continuous parameter changes (e.g., making the bed larger). We find that introducing object category leads to state-of-the-art performance on room layout estimation, while also enabling recognition based only on geometry.
Influence of particle impact angle on formation of profile of single coating track during cold spraying (2018)

In the present paper a model for coating formation under conditions of cold gas-dynamic spraying is constructed with allowance for the dependence of deposition efficiency upon particle impact angle. The model shows the change in the profile of single coating track on a flat substrate from the initial (close to Gaussian function) to the wedge-shaped one, which is observed in experiments. An analytical formula is obtained for the position of maximum coating thickness on an inclined substrate. It shows that displacement is much greater than the displacement of the maximum of particle concentration that takes place on the nozzle axis. The formula obtained allows estimating the value of derivative of dependency of deposition efficiency upon particle impact angle using the measured values of relative deposition efficiency, maximum coating thickness, and maximum thickness position.
Life cycle assessment of European copper mining : A case study from Sweden (2019)

The application of the life cycle assessment (LCA) methodology in the mining sector has the potential to evaluate the environmental sustainability of the primary production of metals. As part of a wider project on developing LCA models and methods for mining, life cycle inventory (LCI) data have been collected at two European copper-producing mine sites, Aitik (Sweden) and Cobre las Cruces (Spain). Results from Aitik, including their impact analysis, identify the use of diesel and explosives, the emission of sulfur dioxide, as well as nitrogen and other emissions in the upstream supply chain of explosives and electricity, as significant contributors to the environmental impact. These outputs have influence on the impact categories Climate Change, Photochemical Ozone Formation, Acidification, as well as Terrestrial and Marine Eutrophication. Due to the increasing incorporation of LCA into legislative demands on the mining sector, mining companies need to establish the necessary infrastructure and framework to be able to provide the required data in a fast, transparent and cost-efficient manner. For this reason, some recommendations to improve communication and data management within the companies have been established from the experience gained within this project.
Investigation of langanite and langatate single crystals for high temperature sensing (2010)

La <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5.5</sub> Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sub> (LGN) and La <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5.5</sub> Ta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sub> (LGT) with trigonal 32 symmetry were grown by Czochralski (CZ) method. High Resolution X-Ray Diffraction (HRXRD) measurement was carried out on the as-grown LGN and LGT crystals for crystal quality evaluation. Frequency temperature dependent behaviors were investigated to explore the zero temperature coefficient of frequency (TCF) cuts at elevated temperature. Among the investigated crystal cuts, (XYt)θ cuts with length extensional vibration mode (LEM) were found to possess high turnover temperature around 250°C, for LGN and LGT crystals. Moreover, LGN (YXl)15° and LGT (YXl)20° crystal cuts, taking advantage of thickness shear vibration mode (TSM), were found to exhibit strong frequency stability in the temperature range of 20~400°C, with turnover temperatures at 280°C and 180°C, respectively. The high electromechanical coupling factor k (>;10%), high mechanical quality factor Q (>;4000), together with the zero TCF characteristics at elevated temperature, indicating LGN and LGT crystals potential for high temperature (100~400°C) sensing applications.
Ostia. Temple du « forum » de la Porta Marina (IV, VIII, 1) (2019)

La vaste place (44 × 39,5 m) pourvue d’une grande exèdre, à laquelle a été donné le nom de Foro di Porta Marina, semble correspondre à un lieu de culte, vraisemblablement public, vu sa superficie et son emplacement (fig. 6, n° 12 ; 260 ; Top. gen. 1953, 135 ; Pensabene 1973, 35-36, n° 80-82 ; Steuernagel 2004, 91 ; Pavolini 2006, 186 ; Pensabene 2007, 222-226). Celle-ci est située hors les murs, au-delà de la Porta Marina, à l’extrémité occidentale du decumanus maximus, à l’est du sanctuaire ...
PPAR Modulating Polyketides from a Chinese Plakortis simplex and Clues on the Origin of Their Chemodiversity (2016)

Fifteen polyketides, including the first hydroxylated plakortone (12) and plakdiepoxide (15), the first polyketide to embed a vicinal diepoxide, have been isolated from the Chinese sponge Plakortis simplex. The structures of the new metabolites were elucidated by analysis of spectroscopic data, Mosher's derivatization, and DFT computational calculations. The reactivity of the major endoperoxide of this sponge was investigated, suggesting that furan, furanylidene, and plakilactone derivatives, well-known classes of natural products, could actually be chemical degradation products. Plakdiepoxide is a potent and selective modulator of peroxisome proliferator-activated receptor (PPAR)-γ, while the diunsaturated C12 fatty acid monotriajaponide (13) activates both PPAR-α and PPAR-γ, a dual activity of potential great importance for the treatment of metabolic disorders.
The DUNIX distributed operating system (1988)

DUNIX is an operating system that integrates several computers, connected by a packet switching network, into a single UNIX machine. As far as the users and their software can tell, the system is a single large computer running UNIX. This illusion is created by cooperation of the computers' kernels. The kernels' mode of operation is novel. The software is procedure call oriented. The code that implements a specific system call (e.g., open) does not know whether the object in question (the file) is local or remote. That uniformity makes the kernel small and easy to maintain. The system behaves gracefully under subcomponents' failures. Users which do not have objects (files, processes, tty, etc) in a given computer are not disturbed when that computer crashes. The system administrator may switch a disk from a "dead" computer to a healthy one, and remount the disk under the original path-name. After the switch, users may access files in that disk via the same old names. DUNIX exhibits surprisingly high performance. For a compilation benchmark, DUNIX is faster than 4.2 BSD, even if in the DUNIX case all the files in question are remote. Currently, in Bell Communications Research we have an installation running DUNIX over five DEC VAX computers connected by an Ethernet. This installation speaks TCP/IP and is on the Internet network.
Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert. (2004)

MRI can be used to noninvasively quantify the intravaginal spread of a therapeutic antifungal agent. Understanding the intravaginal spread of antifungal agents may lead to further optimization of antifungal preparations as well as to better patient instructions.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting (2017)

We prospectively studied the consequences of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in a cohort of children with cystic fibrosis (CF) and a cohort of children with cancer compared to healthy children with no or low antibiotic exposure. The study was conducted in Norway in a low resistance prevalence setting. Sixty longitudinally collected faecal samples from children with CF (n = 32), 88 samples from children with cancer (n = 45) and 127 samples from healthy children (n = 70) were examined. A direct MIC-gradient strip method was used to detect resistant Enterobacteriaceae by applying Etest strips directly onto agar-plates swabbed with faecal samples. Whole genome sequencing (WGS) data were analysed to identify resistance mechanisms in 28 multidrug-resistant Escherichia coli isolates. The prevalence of resistance to third-generation cephalosporins, gentamicin and ciprofloxacin was low in all the study groups. At inclusion the prevalence of ampicillin-resistant E. coli and trimethoprim-sulfamethoxazole-resistant E. coli in the CF group compared to healthy controls was 58.6% vs. 28.4% (p = 0.005) and 48.3% vs. 14.9% (p = 0.001), respectively, with a similar prevalence at the end of the study. The prevalence of resistant enterobacteria was not significantly different in the children with cancer compared to the healthy children, not even at the end of the study when the children with cancer had been treated with repeated courses of broad-spectrum antibiotics. Children with cancer were mainly treated with intravenous antibiotics, while the CF group mainly received peroral treatment. Our observations indicate that the mode of administration of antibiotics and the general level of antimicrobial resistance in the community may have an impact on emergence of resistance in intestinal enterobacteria during antibiotic treatment. The WGS analyses detected acquired resistance genes and/or chromosomal mutations that explained the observed phenotypic resistance in all 28 multidrug-resistant E. coli isolates examined.
The evolution of WT1 sequence and expression pattern in the vertebrates. (1995)

WT1 is a Wilms' tumour predisposition gene, encoding a protein with four C-terminal Kruppel-type zinc fingers, which is also a major regulator of kidney and gonadal development. To pinpoint key regulatory domains involved in development and evolution of the vertebrate genitourinary system, we have isolated WT1 orthologues from all gnathostome classes. Partial nucleotide sequence from chick, alligator, Xenopus laevis and zebrafish reveals extensive conservation. Both the zinc fingers and the transregulatory domain exhibit a high level of similarity in all the species examined. However, of the two alternatively spliced regions only one, the three amino acid KTS insertion between zinc fingers 3 and 4, is found in species other than mammals. The 17 amino acid insertion at the C-terminal end of the transregulatory domain is present only in mammals. Residues with reported human pathological mutations are also unaltered across species, underlining their structural significance. Studies in chick and alligator reveal that the mammalian intermediate mesoderm expression pattern is conserved in birds and reptiles. A wider role in mesodermal differentiation is suggested by expression in some paraxial and lateral mesoderm derivatives.
Two‐dimensional oxide based pressure sensors with high sensitivity (2021)

Abstract Nanomaterials based pressure sensors have obtained world‐wide research interest due to their promising potential applications in health monitoring, artificial intelligence, and electronic skin (e‐skin). Despite the recent progress in sensitivity and detection range of the pressure sensors, the relatively high thickness of the active films has obstructed their applications for e‐skin and degraded the comfortability as wearable devices. We hereby report for the first time a novel pressure sensor based on two‐dimensional metal oxide nanosheets where the gaps between neighboring nanosheets are adjustable. The pressure sensors show a sensitivity of up to 7.2 × 10 6 kPa –1 , which is the highest value ever reported for a pressure sensor. Additionally, the sensor shows good repeatability and excellent stability. The pressure‐sensing ranges can be tuned by adjusting the coverage of the nanosheet film. This work presents an effective strategy to develop ultrathin pressure sensors.
IgG Fc Receptor III Homologues in Nonhuman Primate Species: Genetic Characterization and Ligand Interactions (2006)

Ig Fc receptors bind to immune complexes through interactions with the Fc regions of specific Ab subclasses to initiate or inhibit the defense mechanisms of the leukocytes on which they are expressed. The mechanism of action of IgG-based therapeutic molecules, which are routinely evaluated in nonhuman primate models, involves binding to the low-affinity FcRIII (CD16). The premise that IgG/CD16 interactions in nonhuman primates mimic those present in humans has not been evaluated. Therefore, we have identified and characterized CD16 and associated TCR zeta-chain homologues in rhesus macaques, cynomolgus macaques, baboons, and sooty mangabeys. Similar to humans, CD16 expression was detected on a lymphocyte subpopulation, on monocytes, and on neutrophils of sooty mangabeys. However, CD16 was detected only on a lymphocyte subpopulation and on monocytes in macaques and baboons. A nonhuman primate rCD16 generated in HeLa cells interacted with human IgG1 and IgG2. By contrast, human CD16 binds to IgG1 and IgG3. As shown for humans, the mAb 3G8 was able to block IgG binding to nonhuman primate CD16 and inhibition of nonhuman primate CD16 N-glycosylation enhanced IgG binding. Clearly, differences in interaction with IgG subclasses and in cell-type expression should be considered when using these models for in vivo evaluation of therapeutic Abs.
Synthesis of α‐(aminomethylene)‐9‐(methoxymethyl)‐9H‐purine‐6‐acetic acid derivatives (1990)

Abstract α‐(Aminomethylene)‐9‐(methoxymethyl)‐9 H ‐purine‐6‐acetamide and the ethyl acetate, 3 and 8 , have been synthesized by catalytic hydrogenation of 6‐cyanomethylene‐9‐methoxymethylpurine derivatives 2 and 7 which were obtained by the substitution of 6‐chloro‐9‐(methoxymethyl)purine ( 1 ) with α‐cyanoacetamide and ethyl cyanoacetate, respectively. Substitution of 3 and 8 with amines gave the corresponding N ‐substituted α‐(aminomethylene)‐9‐(methoxymethyl)‐9 H ‐purine‐6‐acetamide and the ethyl acetate 4 and 10 . Reaction of 3 with piperidine gave 9‐(methoxymethyl)‐9 H ‐purine‐6‐acetamide ( 5 ).
Concept Covering for Automated Building Blocks Selection based on Business Processes Semantics (2006)

In this paper we present a novel approach and a system for automated selection of building blocks, by exploiting business processes semantics. The selection process is based on a novel greedy concept covering algorithm, which computes, given a description of the request, the set of needed building blocks. If such a set does not exist the algorithm returns the covered subset and explanation information on both the left uncovered part and conflicting part of the request description, exploiting non-standard inference services. The requested description can be expressed as conjunction of mandatory requirements and preferences. The approach has been deployed in a system specifically designed for SAP R/3 best practices reusability, which is fully functional and is currently being evaluated in an industrial setting.
Gene Transfer by Polyoma-Like Particles Assembled in a Cell-Free System (1983)

Empty capsids of polyoma virus interact with DNA in a cell-free system to form polyoma-like particles (PLP). The DNA in these particles is protected from the action of pancreatic deoxyribonuclease. Transfer of genetic information by PLP has been accomplished by using a restriction fragment containing the transforming sequences of polyoma DNA as a model gene. Infection of rat F111 cells by PLP containing these sequences results in DNA-mediated cellular transformation. Gene transfer by PLP is 50 to 150 times more efficient than by the calcium phosphate precipitation method.
Heterogeneous quantum dot/silicon photonics-based wavelength-tunable laser diode with a 44 nm wavelength-tuning range (2016)

Abstract A heterogeneous wavelength-tunable laser diode combining quantum dot and silicon photonics technologies is proposed. A compact wavelength-tunable filter with two ring resonators was carefully designed and fabricated using silicon photonics technology. The tunable laser combining the wavelength-tunable filter and an optical amplifier, which includes InAs quantum dots, achieved a 44.0 nm wavelength-tuning range at around 1250 nm. The broadband optical gain of the quantum dot optical amplifier was effectively used by the optimized wavelength-tunable filter. This heterogeneous wavelength-tunable laser diode could become a breakthrough technology for high-capacity data transmission systems.
The Flux Qubit Revisited to Enhance Coherence and Reproducibility (2015)

The scalable application of quantum information science will stand on reproducible and controllable high-coherence quantum bits (qubits). Here, we revisit the design and fabrication of the superconducting flux qubit, achieving a planar device with broad frequency tunability, strong anharmonicity, high reproducibility, and relaxation times in excess of $40\,μ$s at its flux-insensitive point. Qubit relaxation times $T_1$ across 22 qubits are consistently matched with a single model involving resonator loss, ohmic charge noise, and 1/f flux noise, a noise source previously considered primarily in the context of dephasing. We furthermore demonstrate that qubit dephasing at the flux-insensitive point is dominated by residual thermal photons in the readout resonator. The resulting photon shot noise is mitigated using a dynamical decoupling protocol, resulting in $T_2\approx 85\,μ$s, approximately the $2T_1$ limit. In addition to realizing an improved flux qubit, our results uniquely identify photon shot noise as limiting $T_2$ in contemporary qubits based on transverse qubit-resonator interaction.
Toward a valid definition of gout flare: Results of consensus exercises using delphi methodology and cognitive mapping (2009)

A short list of features has been identified and now requires validation against a patient- and physician-defined gout flare in order to determine the best combination of features.
From Merck's CCK- Antagonists Via 4-Amino-2(5H)- Furanones towards 5-Hydroxy-Pyrrol-2-Ones: Design, Synthesis and Evaluation of PNB-001 & PNB-081 as Experimental Therapeutic Agents in Pain Management (2018)

Arylated 5-hydroxy-pyrrol-2-ones were prepared in 2 synthetic steps from muco-chloric acid and were optimised as CCK 1 / CCK 2 selective ligands using radio labelled binding assays. A potent CCK 1 selective ligand was identified (PNB-081: CCK1=20nM) as well as a potent CCK 2 ligand (PNB-001, IC50= 22nM) during a systematic SAR optimisation. The antagonism was confirmed for both ligands by using isolated tissue preparations with CCK 5 and CCK8S. Subsequent in vivo evaluation revealed analgesic activity for the gastrin CCK 2 antagonist PNB-001, in the hotplate and tail immersion test at 0.5mg /kg by IP administration in mice. The cholecystokinin antagonist PNB-081 potentiated the analgesic effect of morphine and reversed opiate tolerance in mice from doses >1 mg/kg by oral administration.