gebhart/patrepeval huggingface dataset:
Improved Reservoir Management Through Optimal Control and Continuous Model Updating (2004)

Abstract There is a potential for large improvements in reservoir management by using optimization and model updating techniques in a closed-loop fashion. Here we demonstrate how the combination of the ensemble Kalman filter technique for continuous model updating with an automated adjoint-based water flood optimization algorithm leads to significant improvements in net present value (NPV) of the water flooding process. Using the ensemble Kalman filter, both static parameters (permeabilities) and dynamic variables (pressures and saturations) are updated in the reservoir model as new production measurements become available. Other properties are assumed known in advance. At the start of the production process, in the absence of information on the permeability distribution, an optimal control strategy based on a homogeneous reservoir is used. Subsequently production data are at regular intervals assimilated with the ensemble Kalman filter, resulting in an updated estimate of the reservoir pressures, saturations and permeability field. Based on these updated parameters an optimal water flooding strategy is determined for the remainder of the production process. This process of model updating and optimization is continued over the life of the reservoir. The methodology is applied to two synthetic examples, enabling comparison with traditional production strategies. Significant improvement in NPV, acceleration of oil production, cumulative oil recovery, and reduction of water production were realized. Results were close to those obtained with water flood optimization based on an a-priori known reservoir description. For one example the improvement in cumulative oil recovery is about 44 %, which is quite close to the improvement obtained for an a-priori known reservoir description.
ChemInform Abstract: Sphingosine and Clavaminol H Derivatives Bearing Fluorinated Chains and Their Cytotoxic Activity. (2012)

Abstract Derivatives (III) and (VI) are easily deprotected and further functionalized by standard procedures.
Review of doubled Haploidy methodologies in ornamental species (2011)

Ornamental species are an important group of plants produced mainly for their aesthetic value and to enhance both our indoor and outdoor environments. Development of new germplasm with enhanced colours, fragrances, or longevity is an important aspect of plant breeding programs. Tissue culture methods have been utilized to propagate favourable genotypes. Haploidy methodology is commonly used in many agronomically important crops to speed up the breeding program by developing uniform lines. Haploids and doubled haploid protocols can be used for both practical application, as in breeding, mutagenesis, and genetic transformation, as well as basic research (i.e. biochemical, physiological and genomic studies). This review will focus on in vitro haploid production in several ornamental species.
Nociceptor neurons affect cancer immunosurveillance (2022)

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems<sup>1-5</sup>. Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unclear. Here we show that melanoma cells interact with nociceptor neurons, leading to increases in their neurite outgrowth, responsiveness to noxious ligands and neuropeptide release. Calcitonin gene-related peptide (CGRP)-one such nociceptor-produced neuropeptide-directly increases the exhaustion of cytotoxic CD8<sup>+</sup> T cells, which limits their capacity to eliminate melanoma. Genetic ablation of the TRPV1 lineage, local pharmacological silencing of nociceptors and antagonism of the CGRP receptor RAMP1 all reduced the exhaustion of tumour-infiltrating leukocytes and decreased the growth of tumours, nearly tripling the survival rate of mice that were inoculated with B16F10 melanoma cells. Conversely, CD8<sup>+</sup> T cell exhaustion was rescued in sensory-neuron-depleted mice that were treated with local recombinant CGRP. As compared with wild-type CD8<sup>+</sup> T cells, Ramp1<sup>-/</sup><sup>-</sup> CD8<sup>+</sup> T cells were protected against exhaustion when co-transplanted into tumour-bearing Rag1-deficient mice. Single-cell RNA sequencing of biopsies from patients with melanoma revealed that intratumoral RAMP1-expressing CD8<sup>+</sup> T cells were more exhausted than their RAMP1-negative counterparts, whereas overexpression of RAMP1 correlated with a poorer clinical prognosis. Overall, our results suggest that reducing the release of CGRP from tumour-innervating nociceptors could be a strategy to improve anti-tumour immunity by eliminating the immunomodulatory effects of CGRP on cytotoxic CD8<sup>+</sup> T cells.
Melanopsin-dependent phototransduction is impaired in delayed sleep–wake phase disorder and sighted non–24-hour sleep–wake rhythm disorder (2020)

These results indicate that reduced melanopsin-dependent retinal photo-transduction may be a novel mechanism involved in the development of DSWPD and sighted N24SWD.
<title>Laboratory validation of heterodyne laser radar signal-to-noise expressions for intensity projection generation and image reconstruction</title> (1995)

The Air Force Phillips Laboratory is in the process of demonstrating an advanced space surveillance capability with a heterodyne laser radar (ladar) system to be used, among other applications, for range-resolved imaging. Recently, image domain signal-to-noise rations (SNRs) have been derived both for the intensity projections calculated from the range-resolved reflective data and for image information obtained using linear combinations of the projections. Also, other recent results have indicated that superior image quality is obtained by first converting the heterodyne returns into intensity projections before using tomographic techniques to reconstruct an image, as intensity projections is validated using a laboratory heterodyne setup. In addition, the laboratory results are used to validate the conclusion that intensity projections provide superior image reconstructions.
A 3.6 Gb/s/pin simultaneous bidirectional (SBD) I/O interface for high-speed DRAM (2004)

A point-to-point I/O interface for high-speed DRAM is described. The interface utilizes simultaneous bidirectional signaling that enables transmitting/receiving data through a line at the same time. The test scheme is implemented in 0.10 /spl mu/m DRAM process. It achieves 3.6 Gb/s/pin in SBD mode and an I/O cell consumes 35 mW.
Investigation on the structure of temperature-responsive N-isopropylacrylamide microgels containing a new hydrophobic crosslinker (2015)

Temperature-responsive poly(N-isopropylacrylamide) microgels crosslinked with a new hydrophobic chemical crosslinker was prepared by surfactant-mediated precipitation emulsion polymerization. The temperature-responsive property of the microgel and the influence of the crosslinker on the swelling behaviour was studied systematically by light scattering and small-angle X-ray scattering (SAXS). The radius of gyration (Rg) and the hydrodynamic radius (Rh) of the microgels decreased with increase in temperature due to the volume-phase transition from a swollen to a collapsed state. The ratio of Rg/Rh below the transition temperature was lower than that of hard-spheres due to the lower crosslinking density of the microgels. The SAXS data were analysed by a model in which the microgels were modelled as core-shell particles with a graded interface. The model at intermediate temperatures included a central core and a more diffuse outer layer describing pending polymer chains with a low crosslinking density. In the fully swollen state, the microgels were modelled with a single component with a broad graded surface. In the collapsed state, they were modelled as homogeneous and relatively compact particles. The polymer volume fraction inside the microgel was also derived based on the model and was found to increase with increase in the temperature as a result of collapse of the microgel to compact particles. The polymer volume fraction in the core of the microgel in the collapsed state was about 60% which is higher than that of similar microgels crosslinked with hydrophilic and flexible crosslinkers.
Reports on the 2018 AAAI Spring Symposium Series (2018)

The Association for the Advancement of Artificial Intelligence, in cooperation with Stanford University's Department of Computer Science, presented the 2018 Spring Symposium Series, held March 26–28, 2018, on the campus of Stanford University. The seven symposia held were AI and Society: Ethics, Safety, and Trustworthiness in Intelligent Agents; Artificial Intelligence for the Internet of Everything; Beyond Machine Intelligence: Understanding Cognitive Bias and Humanity for Well‐Being AI; Data‐Efficient Reinforcement Learning; The Design of the User Experience for Artificial Intelligence (the UX of AI); Integrated Representation, Reasoning, Learning, and Execution for Goal‐Directed Autonomy; Learning, Inference, and Control of Multiagent Systems. This report, compiled from organizers of the symposia, summarizes the research of the symposia that took place.
Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta‐analysis of randomized double‐blind controlled trials (2006)

Oral magnesium supplementation for 4-16 weeks may be effective in reducing plasma fasting glucose levels and raising HDL cholesterol in patients with Type 2 diabetes, although the long-term benefits and safety of magnesium treatment on glycaemic control remain to be determined.
Echo Cancellation for Speech Signals (1999)

Abstract The sections in this article are Line Echoes Adaptive Cancellation Single‐Channel Acoustic Echo Cancellation Multichannel Acoustic Echo Cancellation Concluding Remarks Acknowledgments
A light–heat synergism in the sub-bandgap photocatalytic response of pristine TiO2: a study of in situ diffusion reflectance and conductance (2022)

Pristine TiO<sub>2</sub> materials are mainly used as photocatalysts under super-bandgap light illumination. The sub-bandgap (SBG) photocatalytic response has seldom been investigated and the mechanism of action remains unclear. In the current research, we firstly study the SBG light electronic transition of pristine P25 TiO<sub>2</sub> by means of <i>in situ</i> diffusion reflectance and (photo)conductance measurements under finely controllable conditions. It is revealed that the SBG light can promote valence band (VB) electrons to the exponentially-distributed gap states of the TiO<sub>2</sub>, which can then be thermally activated to the CB states. A hole in the VB and an electron in the CB can be generated by the synergism of a SBG photon and heat. It is also seen that the photoinduced electrons can transfer to O<sub>2</sub> through the CB states, and that the holes can be captured by isopropanol molecules. As a result, isopropanol dehydrogenation can occur over pristine TiO<sub>2</sub> under SBG light illumination. It is seen that the photocatalytic activity increases with temperature and the energy of the SBG photons, in agreement with the light-heat synergistic electric transition <i>via</i> the exponential gap states. The present research reveals a mechanism for the SBG light photocatalytic response of pristine TiO<sub>2</sub> materials, which is important in designing highly-active visible light active photocatalysts.
Yellow Fever and Other Viruses in West Africa (2023)

This chapter chronicles experiences in field investigations of outbreaks of yellow fever, Lassa fever and other arboviruses over a number of years during my career at the Centers for Disease Control (CDC) and acknowledges many of the remarkable people who contributed to these activities. The catalyst and impetus for my career pathway has always been my curiosity and fascination with the complex underlying ecology and pathogenesis of yellow fever and other arboviruses.
Matter over mind: physical wellbeing for people with severe mental illness (2004)

Mental health workers have a huge responsibility in terms of maintaining the balance between the mental and physical health of people who have a serious mental illness. While it is well established that mental and physical wellbeing are inseparable, the current system means clients are parcelled out to consultant psychiatrists, general practitioners (GPs), community psychiatric nurses (CPNs) and social workers. This fragmented, albeit multidisciplinary, method provides mental health nurses with the opportunity to play a crucial role in the delivery of an integrated, holistic approach to client care. This is an opportunity too good to miss.
C - reactive protein and chitinase 3-like protein 1 as biomarkers of spatial redistribution of retinal blood vessels on digital retinal photography in patients with diabetic retinopathy (2014)

The aim of the study was to investigate the correlation between the levels of C-reactive protein (CRP) and chitinase 3-like protein 1 (YKL-40) in blood samples with morpohometric parameters of retinal blood vessels in patients with diabetic retinopathy. Blood laboratory examination of 90 patients included the measurement of glycemia, HbA1C, total cholesterol, LDL-C, HDL-C, triglycerides and CRP. Levels of YKL-40 were detected and measured in serum by ELISA (Micro VueYKL-40 EIA Kit, Quidel Corporation, San Diego, USA). YKL-40 correlated positively with diameter and negatively with number of retinal blood vessels. The average number of the blood vessels per retinal zone was significantly higher in the group of patients with mild non-proliferative diabetic retinopathy than in the group with severe form in the optic disc and all five retinal zones. The average outer diameter of the evaluated retinal zones and optic disc vessels was significantly higher in the group with severe compared to the group with mild diabetic retinopathy. Morphological analysis of the retinal vessels on digital fundus photography and correlation with YKL-40 may be valuable for the follow-up of diabetic retinopathy.
A Low Band Gap Conjugated Polymer for Supercapacitor Devices (2006)

We present the electrochemical polymerization and characterization of a stable and dopable polyindophenine derivative starting from monomer 5. The fabrication of supercapacitor devices was carried out by direct electrochemical polymerization on an ITO-coated slide. Furthermore, the galvanostatic and potentiostatic experiments conducted on these supercapacitors have shown that the polyindophenine-derivative material has very good cyclability, over a potential range of 1.4 V, and a maximum capacitance of 140 F g(-1).
Decision feedback equalization for Bluetooth systems (2002)

Gaussian frequency shift keying modulation has been chosen as the modulation technique for the physical layer of Bluetooth. Bluetooth is a standard for low cost and low power wireless communications between various mobile devices. The optimal demodulation of a GFSK signal involves an extremely complex Viterbi decoder. Therefore designers have opted for the noncoherent detection of GFSK which uses a frequency discriminator, followed by symbol by symbol detection. We describe a decision feedback equalizer to be added after the discriminator. The DFE receiver gives gains in excess of 2 dB. We also describe how to increase the current data rate of a Bluetooth system by increasing the symbol rate and not the alphabet size.
Variable expression of cerebral cavernous malformations in carriers of a premature termination codon in exon 17 of the Krit1 gene (2003)

Patients in this family, harbouring the same mutation, illustrate the very variable clinical and radiological expression of a Krit1 mutation. The early and critical onset in the proband contrasts with minor clinical findings in affected relatives. This consideration is important in genetic counselling.
Antarctic sea ice control on ocean circulation in present and glacial climates (2014)

In the modern climate, the ocean below 2 km is mainly filled by waters sinking into the abyss around Antarctica and in the North Atlantic. Paleoproxies indicate that waters of North Atlantic origin were instead absent below 2 km at the Last Glacial Maximum, resulting in an expansion of the volume occupied by Antarctic origin waters. In this study we show that this rearrangement of deep water masses is dynamically linked to the expansion of summer sea ice around Antarctica. A simple theory further suggests that these deep waters only came to the surface under sea ice, which insulated them from atmospheric forcing, and were weakly mixed with overlying waters, thus being able to store carbon for long times. This unappreciated link between the expansion of sea ice and the appearance of a voluminous and insulated water mass may help quantify the ocean's role in regulating atmospheric carbon dioxide on glacial-interglacial timescales. Previous studies pointed to many independent changes in ocean physics to account for the observed swings in atmospheric carbon dioxide. Here it is shown that many of these changes are dynamically linked and therefore must co-occur.
Analysis by 13C Measurement on Mechanism of Cultivar Difference in Leaf Photosynthesis of Rice (Oryza sativa L.) (1996)

Our previous paper showed that cultivar difference of flag leaf photosynthesis (LPS) in rice (Oryza sativa L.) was attributed to the difference in mesophyll resistance (rm). In this paper, we tried to divide rm into CO2 transfer resistance (rm) and CO2 fixation resistance (rc) for further analysis of rm by means of δ13C determination of photosynthetic products. In the heading time, rr, and rc occupied 14, and 58% in the total resistance, respectively, in average through 31 cultivars. This suggests that cultivar difference of LPS is mainly caused by the difference of rc. The percentage ratios of each resistance to the total one were maintained comparatively constant through the senescing process of the flag leaves. Moreover, the CO2 concentration in CO2 fixating site showed almost the same values in different cultivars in a whole life span of a flag leaf. The rc showed a close correlation with ribulose-l,5-bisphosphate carboxylase/ oxygenase (RubisCO) content. Carbonic anhydrase (CA) activity showed no correlation with rr, but showed positive correlation with rc. It was suggested that a mutual regulation system between CA activity and RubisCO activity could exist.
Asynchronous design using commercial HDL synthesis tools (2002)

New design technologies rely on truly reusable IP blocks with simple means of assembly. Asynchronous methodologies could be a promising option to implement these requirements. Promotion of asynchronous design strongly depends upon the "level of service" delivered to the designer. Current asynchronous design tools require a significant re-education of designers and their capabilities are far behind synchronous commercial tools. One solution to these problems, which we advance in this paper, is to stick to a conventional design flow as closely as possible and to use commercial design tools as much as possible. The paper considers a particular subclass of asynchronous circuits (Null Convention Logic or NCL) and suggests a design flow which is completely based on commercial CAD tools. It argues about the trade-off between the simplicity of design flow and the quality of obtained implementations.
Micromorphological, anti-nociceptive and anti-inflammatory investigations of stem bark of Daniellia oliveri (2006)

Anatomical and powdered samples of stem bark of Daniellia oliveri were investigated for its micromorphological profile, while the aqueous extract was investigated for its anti-nociceptive and antiinflammatory effects in mice and rats, respectively. The micromorphological study indicated the presence of characteristic bundles of phloem tissues, separated by medullary rays, abundant grains of starch in isodiametric parenchyma cells, prisms of calcium oxalate crystals, cork cells and cortex parenchyma. The extract showed a significant anti-nociceptive activity at the tested doses (50, 100, 200 mg/kg i.p.). The extract at the same doses showed a non-dose dependent anti-inflammatory activity. The effect was significant at doses of 100 and 200 mg/kg. These findings contribute to the preparation of a monograph for proper identification of the plant and also corroborate some of the traditional uses.
SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells (2021)

Emerging strategies to improve healthy aging include dietary interventions as a tool to promote health benefits and reduce the incidence of aging-related comorbidities. The health benefits of milk are also linked to its richness in betaines and short-chain acylcarnitines, which act synergistically in conferring anticancer, anti-inflammatory, and antioxidant properties. Whey, despite being a dairy by-product, still has a considerable content of bioactive betaines and acylcarnitines. Here, we investigated the anticancer properties of whey from Mediterranean water buffalo (<i>Bubalus bubalis</i>) milk by testing its antiproliferative effects in colorectal cancer (CRC) cells HT-29, HCT 116, LoVo and SW480. Results indicated that treatment with whey for 72 h inhibited cell proliferation (<i>p</i> < 0.001), induced cell cycle arrest, and apoptosis via caspase-3 activation, and modulated cell metabolism by limiting glucose uptake and interfering with mitochondrial energy metabolism with the highest effects observed in HT-29 and HCT 116 cells. At molecular level, these effects were accompanied by upregulation of sirtuin 3 (SIRT3) (<i>p</i> < 0.01) and peroxisome proliferator-activated receptor (PPAR)-γ expression (<i>p</i> < 0.001), and downregulation of lactate dehydrogenase A (LDHA) (<i>p</i> < 0.01), sterol regulatory-element binding protein 1 (SREBP1) (<i>p</i> < 0.05), and PPAR-α (<i>p</i> < 0.01). Transient SIRT3 gene silencing blocked the effects of whey on the LDHA, PPAR-γ, and PPAR-α protein expressions (<i>p</i> < 0.01) suggesting that the whey capacity of perturbating the metabolic homeostasis in CRC cell lines is mediated by SIRT3.
Site-dependence of van der Waals interaction explains exciton spectra of double-walled tubular J-aggregates (2015)

The simulation of the optical properties of supramolecular aggregates requires the development of methods, which are able to treat a large number of coupled chromophores interacting with the environment. Since it is currently not possible to treat large systems by quantum chemistry, the Frenkel exciton model is a valuable alternative. In this work we show how the Frenkel exciton model can be extended in order to explain the excitonic spectra of a specific double-walled tubular dye aggregate explicitly taking into account dispersive energy shifts of ground and excited states due to van der Waals interaction with all surrounding molecules. The experimentally observed splitting is well explained by the site-dependent energy shift of molecules placed at the inner or outer side of the double-walled tube, respectively. Therefore we can conclude that inclusion of the site-dependent dispersive effect in the theoretical description of optical properties of nanoscaled dye aggregates is mandatory.