gebhart/patrepeval huggingface dataset:
Regulation of Vasopressin V1b Receptors and Stress Adaptation (2004)

Vasopressin (VP) regulates pituitary corticotroph function by acting upon plasma membrane G-protein receptors of the V1b subtype (V1bR), coupled to calcium-phospholipid signaling. The number of these receptors in the anterior pituitary varies during stress in direct correlation with corticotroph responsiveness, suggesting that the V1bR plays an important role during adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to stress. The molecular regulation of pituitary V1bR involves transcriptional and translational mechanisms. V1bR gene transcription, which is necessary to maintain V1bR mRNA levels, depends on a number of responsive elements in the promoter region, of which the stretch of GA repeats near the transcription start point (GAGA box) is essential. Although transcriptional activation is necessary to maintain V1bR mRNA levels, the lack of correlation between VP binding and V1bR mRNA suggests that V1bR content is mainly regulated at the translational level. Two potential mechanisms by which the 5' untranslated region (5'UTR) of the V1bR mediates negative and positive regulation of V1bR translation were identified. This includes the repressor effect of small open reading frames (ORF) present upstream of the main V1bR ORF, and an internal ribosome entry site (IRES), which activates V1bR translation. The existence of multiple loci of regulation for the V1bR at transcriptional and translational levels provides a mechanism to facilitate plasticity of regulation of the number of pituitary vasopressin receptors according to physiological demand.
Model-Driven SIMD Code Generation for a Multi-resolution Tensor Kernel (2011)

In this paper, we describe a model-driven compile-time code generator that transforms a class of tensor contraction expressions into highly optimized short-vector SIMD code. We use as a case study a multi-resolution tensor kernel from the MADNESS quantum chemistry application. Performance of a C-based implementation is low, and because the dimensions of the tensors are small, performance using vendor optimized BLAS libraries is also sub optimal. We develop a model-driven code generator that determines the optimal loop permutation and placement of vector load/store, transpose, and splat operations in the generated code, enabling portable performance on short-vector SIMD architectures. Experimental results on an SSE-based platform demonstrate the efficiency of the vector-code synthesizer.
Facile Synthesis and Hierarchical Assembly of Hollow Nickel Oxide Architectures Bearing Enhanced Photocatalytic Properties (2008)

A solvothermal method combining a calcination process was conducted to synthesize NiO hierarchical architectures with controllable morphologies and sizes. First, several hollow α-Ni(OH)2 hierarchical architectures assembled by α-Ni(OH)2 nanosheets had been synthesized through the solvothermal method. The nucleation-mediated mechanism overwhelmingly determined the morphology of hollow α-Ni(OH)2 architectures through tuning the nucleation rate. The hollow α-Ni(OH)2 spheres could be formed in the case of high nucleation rate. However, the hollow α-Ni(OH)2 tubes would be obtained at low nucleation rate. Second, the hollow NiO hierarchical architecture could be obtained from the precursor without changing their morphologies by a simple calcination procedure. The as-obtained hollow NiO hierarchical architectures showed high photocatalytic property to decompose acid red 1 pollutant and could also be easily recycled under an external magnetic field, displaying great potential in environmental pollutant cleanup applications.
Scheduling by ''abductive execution'' of a classical logic specification (1997)

status: Published
Recovery time of superconducting non-inductive reactor type fault current limiter (1996)

A superconducting fault current limiting device for electric power systems has been investigated to determine its feasibility. A noninductive reactor type fault current limiter has been constructed using a metal superconductor. Two bifilar wound solenoids were connected in antiparallel or antiseries. On each connection, a fault current limiting test was performed by suddenly short-circuiting a resistive load. The recovery (normal-to-superconductive state transition) time after the current limiting mode has been studied using a small-scale model of a fault current limiter for an LV power distribution line. The results reveal that the current limiter could be operated under a repetitive fault current accident which was removed within a few cycles of the limiting mode. The recovery time is a function of the dissipated energy under current limiting mode. Test results are presented.
Pathological mechanisms and therapeutic outlooks for arthrofibrosis (2019)

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract pouches, bursae and tendons, cause pain and prevent a normal range of joint motion, with devastating consequences for patient quality of life. Arthrofibrosis affects people of all ages, with published rates varying. The risk factors and best management strategies are largely unknown due to a poor understanding of the pathology and lack of diagnostic biomarkers. However, current research into the pathogenesis of fibrosis in organs now informs the understanding of arthrofibrosis. The process begins when stress signals stimulate immune cells. The resulting cascade of cytokines and mediators drives fibroblasts to differentiate into myofibroblasts, which secrete fibrillar collagens and transforming growth factor-β (TGF-β). Positive feedback networks then dysregulate processes that normally terminate healing processes. We propose two subtypes of arthrofibrosis occur: active arthrofibrosis and residual arthrofibrosis. In the latter the fibrogenic processes have resolved but the joint remains stiff. The best therapeutic approach for each subtype may differ significantly. Treatment typically involves surgery, however, a pharmacological approach to correct dysregulated cell signalling could be more effective. Recent research shows that myofibroblasts are capable of reversing differentiation, and understanding the mechanisms of pathogenesis and resolution will be essential for the development of cell-based treatments. Therapies with significant promise are currently available, with more in development, including those that inhibit TGF-β signalling and epigenetic modifications. This review focuses on pathogenesis of sterile arthrofibrosis and therapeutic treatments.
Compounds with bridgehead nitrogen 68—NMR spectra and stereochemistry of perhydropyrido [1,2‐c] [1,3]oxazines (1992)

Abstract Low‐temperature 13 C NMR spectroscopy shows perhydropyrido [1,2‐ c ] [1,3]oxazine to adopt a conformational equilibrium in CD 2 Cl 2 –CFCl 3 solution containing 98% trans fused conformer in equilibrium with 2% O ‐outside‐ cis fused conformer at 203 K. A similar equilibrium position is adopted by the trans ‐(H‐4,H‐4a)‐4‐methylperhydropyrido[1,2‐ c ][1,3]oxazine, whereas the C‐4 epimer adopts exclusively the trans fused conformation.
MODELING GENETIC Diseases through Reprogramming of HUMAN Amniotic Liquid Derived CELLS (2010)

Abstract Abstract 4789 Pluripotency and self-renewal, two key characteristics of induced pluripotent stem cells (IPS), make these cells ideally suited for modeling diseases in vitro and generating biological resources usable for drug screening and cell therapy. However, the reprogramming efficiency of somatic cells greatly varies according to the cell type, to the in vitro proliferation index, the number of passages and the age of the donor. Human amniotic liquid-derived cells (hALDC), collected during amniocentesis for the prenatal diagnosis of genetic diseases, represent an abundant source of primary cells. In preliminary experiments we have shown that hALDC expressed endogenous Oct4 and Sox2 proteins suggesting that could be readily amenable to reprogramming. To this end, we have used two strategies using either hALDC or neonatal fibroblasts: (1) lentivirus mediated gene transfer of OCT4, SOX2, LIN28, NANOG, (2) retroviruses mediated gene transfer of OCT4, SOX2, CMYC, KLF4 and (3) lentiviral transfer of OCT4, SOX2. hALDC transduced by these viruses were placed on MEF and b-FGF (10 ng/ml) with daily medium changes. One to three weeks after infection, typical human ES-like colonies could be picked up for expansion before being characterized. HALDC show an increased reprogramming potential with the [OCT4, SOX2, LIN28, NANOG] and [OCT4, SOX2] cocktails, when compared to reprogramming of neonatal fibroblasts. Twelve hALDC-derived-IPS cells were obtained from 12 different samples of amniotic fluid. All hALDC-IPS cell lines maintained a normal karyotype in culture and displayed the morphology and characteristics of human embryonic stem cells, including the surface expression of Tra-160, SSEA-3, SSEA-4, HESCA-1 and alkaline phosphatase, and formed multi-lineaged teratomas upon injection to NOD-SCID mice. Gene expression profiles of the IPS cell lines reveal a high correlation coefficient between hALDC-iPS cells and human embryonic stem cells, and a low correlation between hALDC-iPS and hALDC. When compared to hES cells H1, H9 and Cl01, these cell lines generated hematopoiesis with a variable efficiency in vitro. Amongst the hALDC-IPS cell lines generated by our laboratory (http://www.hescreg.eu/) four lines carry an inherited trisomy of chromosome 21, and three lines carry the homozygous “S” mutation in the beta-globin gene of sickle-cell anemia. All hALDC-IPS cell are currently banked at the Human Pluripotent Stem Cell Core Facility, France. In conclusion, hALDC can be rapidly and efficiently reprogrammed to pluripotency with a limited number of transgenes. Moreover, hALDC-IPS cell lines derived from patients can be used to modelize in vitro the phenotypic features of monogenic diseases such as sickle cell anemia or more complex, multifactorial disorders such as Down's syndrom. The ability to generate hematopoietic differentiation from these cell lines will facilitate the modelling of these hematopoietic disorders. Disclosures: No relevant conflicts of interest to declare.
Regional cerebral blood flow in mood disorders: IV. Comparison of mania and depression (1995)

Cortical regional cerebral blood flow (rCBF) was assessed in minimally medicated, relatively young adults in episodes of either acute mania (n = 11) or major depression (n = 11) and in matched normal control subjects (n = 11), using the 133xenon inhalation method, under eyes-closed, resting conditions. The three groups were equivalent in global CBF. Both patient groups showed significant reductions of rCBF in anterior cortical areas and reduction of the normal anteroposterior gradient. In addition, there was evidence of abnormal, albeit similar, patterns of flow lateralization on a regional basis in both clinical groups compared with normal subjects. An exploratory analysis revealed preliminary evidence of rCBF differences between the clinical groups, localized to the inferior frontal cortex. Otherwise, the evidence in this study suggests that young adult manic and depressed patients are predominantly similar in cortical rCBF parameters.
Degradation analysis of an operating PV module on a Farm Sanctuary (2018)

Silicon photovoltaic (PV) modules are considered the most reliable component of a photovoltaic system and according to the manufacturers have a lifetime from 25 to 30 years. However, some modules degrade or fail along their service time under outdoor exposure and harsh conditions. The reliability and lifetime of a module depend on its energy conversion performance and degradation modes. For better understanding of the mechanisms behind the degradation and failure of PV modules, this study reviews the governing degradation modes and investigates a ten-year-old operating crystalline silicon PV module installed at an active farm and animal sanctuary. Field current-voltage testing and Infrared imaging for hot spot detection have been employed in examining this PV module showing localized damaged regions. While new remote sensing tools are being deployed to monitor large-scale PV systems, this study provides a basic overview of PV reliability to small-scale community users. This work exemplifies academic-community collaborations in the field of sustainability.
Real time execution of optimal edge detectors on RISC and DSP processors (2002)

This paper presents the real time implementations of the Canny-Deriche (1986, 1990) optimal edge detectors on RISC and DSP processors. For each type of architecture, the most leading optimization techniques are described. A comparison is then made between RISC and DSP processing speeds.
Plasmids in diatom species (1991)

We have discovered plasmids in 5 of 18 diatom species surveyed. In several species, more than one type of plasmid is present. Several of the plasmids show similarity by hybridization previously characterized plasmids in Cylindrotheca fusiformis (J. D. Jacobs et al., unpublished data). Additionally, there is similarity between the plasmids found in C. fusiformis and chloroplast DNA in three diatom species. These results add to the evidence that the plasmids have features of mobile genetic elements.
Use of Wellbore-Reservoir Coupled Dynamic Simulation to Evaluate the Cycling Capability of Liquid-Loaded Gas Wells (2010)

Abstract The regulated intermittent gas production by automated on/off of the wellhead choke, also called "well cycling", is often the only short-term option that the offshore operators can practice in order to prolong the well production life once they are loaded up by liquid. The field experiences show that many wells can be cycled for quite a long period, but some other wells may have no cycling capability at all. For the wells that can be cycled, the average production achieved by the cycling also depends on whether and how this process is controlled. These bring in a large uncertainty in predicting the field tail-end production. This paper is therefore concerned with the numerical modeling and simulation of the regulated well cycling. As the process involves both wellbore and near-wellbore reservoir dynamics, an integrated modeling approach is adopted through coupling a transient well flow model to a near-wellbore reservoir model. The coupled model was successfully used to investigate the cycling potential of a 3-km deep vertical well that produces from a depleted cylindrical reservoir of 100 meters in thickness and 560 meters in radius. The simulation results confirm that the selected well can be cycled for a long period only if the operator pro-actively starts the cycling before the well is loaded up by liquid. The simulation also shows that the average gas production for the selected well can be at least doubled compared with the meta-stable production rate resulting from leaving the choke permanently open, which confirms the advantage of well cycling. The major observation in this paper may fundamentally change the offshore gas well operation strategy as that the operators may start well cycling once they foresee liquid loading is soon due to occur in their wells. Besides, the simulation procedure presented can provide advices on how to optimize the timing of the choke on/off operation to maximize the average production.
ChemInform Abstract: Oligodeoxynucleotide Synthesis. H‐Phosphonate Approach (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA (2016)

The review findings indicate that hypnotic medications are associated with suicidal ideation. Future studies should be designed to assess whether increases in suicidality result from CNS impairments from a given hypnotic medication or whether such medication decreases suicidality because of improvements in insomnia.
Niereninsuffizienz und Hypertonie - Renoprotektion durch ACE-Hemmer (2007)

ACE-Hemmer finden ihren Einsatz auch in der tierärztlichen Praxis vorwiegend bei Herzerkrankungen. Durch ihren Angriffspunkt im Renin-Angiotensin-Aldosteron-System leisten sie aber auch hervorragende Dienste in der Therapie der chronischen Niereninsuffizienz.
Microwave Plasma Chemical Vapor Deposition of Carbon Coatings on LiNi[sub 1∕3]Co[sub 1∕3]Mn[sub 1∕3]O[sub 2] for Li-Ion Battery Composite Cathodes (2008)

In this paper we report results of a synthesis method of thin-film conductive carbon coatings on cathode active material powders for lithium-ion batteries. Thin layers of graphitic carbon were produced from a solid organic precursor, anthracene, by a one-step microwave plasma chemical vapor deposition (MPCVD) method. The structure and morphology of the carbon coatings were examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectroscopy. The composite electrodes were electrochemically tested in lithium half coin cells. The composite cathodes made of the carbon-coated powder showed superior electrochemical performance and increased capacity compared to standard composite electrodes.
Time transfer using an asynchronous computer network: Results from three weeks of measurements (2007)

We have performed a time transfer experiment between two atomic clocks, over a distance of approximately 75 km using an 10 Gbit/s asynchronous fiber-optic computer network. The time transfer was accomplished through passive listening on existing data traffic and a pilot sequence in the SDH bit stream. In order to assess the fiber-link clock comparison, we simultaneously compared the clocks using a GPS carrier phase link. The standard deviation of the difference between the two time transfer links over the three-week time period was 243 ps.
Tocopherol distribution and oxidative stability of oils prepared from the hypocotyl of soybeans roasted in a microwave oven (1999)

Abstract Whole soybeans ( Glycin max L.) were roasted by exposure to microwaves at a frequency of 2,450 MHz, and their hypocotyls were separated from other tissues (seed coat and cotyledons). The quality characteristics and composition in the hypocotyl oils were studied in relation to their tocopherol distributions and were evaluated as compared to an unroasted oil sample. Only minor increases ( P &lt;0.05) in chemical and physical changes of the oils, such as carbonyl value, anisidine value and color development, occurred with increased roasting time. Significant decreases ( P &lt;0.05) were observed in the amounts of phospholipids in the oils after microwave roasting. Nevertheless, compared to the original level, more than 80% tocopherols still remained after 20 min of roasting. These results suggest that the exposure of soybeans to microwaves for 6 to 8 min caused no significant loss or changes in the content of tocopherols and polyunsaturated fatty acids in the hypocotyls. Therefore, a domestic microwave oven would be useful as a simple and quick means for preparing hypocotyl oil of good quality.
Some 2,4,6-Triamino-5-alkyl- and 5-Benzylpyrimidines (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome 2,4,6-Triamino-5-alkyl- and 5-BenzylpyrimidinesPeter B. Russell and George H. HitchingsCite this: J. Am. Chem. Soc. 1952, 74, 13, 3443–3444Publication Date (Print):July 1, 1952Publication History Published online1 May 2002Published inissue 1 July 1952https://pubs.acs.org/doi/10.1021/ja01133a529https://doi.org/10.1021/ja01133a529research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. (1993)

Inflammatory cell infiltrates and cell adhesion molecule expression have been examined in normal human skin after intradermal injection of sensory neuropeptides substance P (n = 6), vasoactive intestinal polypeptide (n = 6), and calcitonin gene-related peptide (n = 6) together with PBS as control (n = 4). Each neuropeptide induced rapid, time-dependent neutrophil influx into dermis, which was initially observed at 15 min and persisted for 8 h after injection. Increases in numbers of neutrophils with time after substance P, vasoactive intestinal polypeptide and calcitonin gene-related peptide were highly significant when compared with controls p < 0.005, p < 0.005, p < 0.005, respectively (analysis of variance). Substance P additionally induced marked eosinophilic accumulation at 4 and 8 h in four of six subjects. These changes paralleled rapid translocation of P-selectin from cytoplasmic Weibel-Palade granules to luminal membranes by 15 min, and significant up-regulation of E-selectin expression at 4 and 8 h. Increases in percentage of E-selectin positive vessels with respect to time after each neuropeptide were highly significant when compared with controls, p < 0.005, p < 0.005, p < 0.005 (ANOVA), respectively, and were significantly correlated with neutrophil infiltrates, r = 0.55, p < 0.001. VCAM-1 was not expressed, and constitutive ICAM-1 expression on dermal endothelium was unchanged at all time points examined (0-8 h). Induction of endothelial adhesion molecule expression by neuropeptides provides a mechanism for neutrophil accumulation in neurogenic inflammation. Substance P-induced eosinophil accumulation in the absence of VCAM-1 expression suggests that mechanisms distinct from VCAM-1/very late antigen-4 binding mediate selective tissue eosinophilia.