gebhart/patrepeval huggingface dataset:
Optimization and characterization of a differential quantum gravimeter (2022)

&amp;lt;p&amp;gt;Measuring the acceleration of the Earth&amp;amp;#8217;s gravity &amp;lt;em&amp;gt;g&amp;lt;/em&amp;gt; and the gravity gradient simultaneously and at the same location promises to provide enhanced information about the distribution of underground masses, especially at shallow depths [1]. Quantum sensors relying on Atom Interferometry with laser cooled-atoms [2,3] is a technology of choice to implement such new sensing capability and an industry-grade demonstrator has been recently developed [4] by iXblue.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;This Differential Quantum Gravimeter (DQG) has been operational for more than two years and has demonstrated state-of-the-art sensitivity mainly limited by Quantum Projection Noise down to a noise floor at about 40E/sqrt(tau). We will present as well a 21 day long run with the demonstration of a resolution below 1E for the measurement of the vertical gravity gradient (1E = 10&amp;lt;sup&amp;gt;-9&amp;lt;/sup&amp;gt; s&amp;lt;sup&amp;gt;-2&amp;lt;/sup&amp;gt; = 0.1 &amp;amp;#181;Gal/m) and 0.5 &amp;amp;#181;Gal for the measurement of &amp;lt;em&amp;gt;g&amp;lt;/em&amp;gt;. Moreover in order to illustrate the potential for mass balance monitoring and gravity survey we will present a proof-of-principle experiment with realistic masses and measurement duration. We will provide insight on an previsional accuracy budget and main biases.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;The compactness of the instrument and the field-tested technology [5] on which it is based, allows to consider the deployment of this new sensor in real environment as a future short-term outcome to investigate both spatial and temporal mass balance in the field. Promising case studies will be discussed, as this type of sensor can sense mass changes that are not detected by gravimeters.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;[1] G. Pajot, O. de Viron, M. M. Diament, M. F. Lequentrec-Lalancette, V. Mikhailov, GEO-PHYSICS &amp;lt;strong&amp;gt;73&amp;lt;/strong&amp;gt;, 123 (2008).&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;[2] R.Geiger, A.Landragin, S.Merlet, F.P.D.Santos, &amp;lt;em&amp;gt;AVS QuantumScience &amp;lt;/em&amp;gt;&amp;lt;strong&amp;gt;2&amp;lt;/strong&amp;gt;, 024702(2020).&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;[3] V. M&amp;amp;#233;noret et al., &amp;quot;Gravity measurements below 10&amp;amp;#8722;9 g with a transportable absolute quantum gravimeter&amp;quot;, &amp;lt;em&amp;gt;Nature Scientific Reports&amp;lt;/em&amp;gt;, vol.&amp;amp;#160;&amp;lt;strong&amp;gt;8&amp;lt;/strong&amp;gt;,&amp;amp;#160;12300 (2018)&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;[4] A compact differential gravimeter at the quantum projection noise limit,&amp;lt;em&amp;gt; to be published in Physical Review &amp;lt;/em&amp;gt;A&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;[5] A.-K. Cooke, C. Champollion, N. Le Moigne, &amp;lt;em&amp;gt;Geoscientific Instrumentation, Methods and &amp;lt;/em&amp;gt;&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;em&amp;gt;Data Systems Discussions&amp;lt;/em&amp;gt; 2020, &amp;lt;strong&amp;gt;1&amp;lt;/strong&amp;gt; (2020).&amp;lt;/p&amp;gt;
Using ATPG for clock rules checking in complex scan designs (2002)

Structured Design-For-Testability (DFT) employs automated Design-Rules-Checking (DRC) to ensure a design is testable and test patterns can be produced using Automated Test Pattern Generation (ATPG). Central to DRC are ATPG-related clock rules. This paper defines a robust set of clock rules and their implementation for scan designs. It then extends clock-rule-violation detection beyond test requirements, which provides fast clock verification early in the design cycle, complementing the more complex and slower timing tools. Results on a large microprocessor design show the applicability of ATPG-based timing verification.
ChemInform Abstract: General Synthetic Entry to Highly‐Oxygenated, Angularly‐Fused Polycyclic Aromatic Compounds. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hereditary afibrinogenemia: from genetics to treatments (2021)

L’afibrinogénémie héréditaire est une maladie rare de la coagulation caractérisée par l’absence complète de fibrinogène. La plupart des anomalies génétiques à l’origine de l’afibrinogénémie sont des mutations nulles empêchant la synthèse, l’assemblage intracellulaire ou la sécrétion du fibrinogène dans la circulation. La symptomatologie hémorragique est au premier plan, souvent dès la naissance, avec des saignements du cordon ombilical. Le phénotype hémorragique est sévère, avec des manifestations fréquentes, en particulier aux niveaux musculaire, articulaire et cérébral. Paradoxalement, les patients avec afibrinogénémie sont aussi à risque d’évènements thrombotiques, parfois dès le jeune âge. Les territoires veineux et artériels sont atteints de manière similaire, suggérant un mécanisme physiopathologique commun. D’autres symptômes tels que des kystes osseux, un retard de cicatrisation ou des ruptures spontanées de la rate sont observés et affectent également la qualité de vie des patients. Plusieurs concentrés en fibrinogène sont disponibles, dont les propriétés pharmacocinétiques, l’efficacité et le profil de sécurité sont semblables. En cas de saignement, la supplémentation en fibrinogène est déterminée par la sévérité et le type de saignement en visant une concentration de fibrinogène cible &gt; 1-1,5 g/L. La prise en charge d’un événement thrombotique nécessite à la fois la mise en place d’une supplémentation en fibrinogène et l’introduction d’un traitement anticoagulant. La grossesse et l’accouchement sont des situations particulièrement à risque. Elles nécessitent une prise en charge multidisciplinaire et une supplémentation en fibrinogène avec une augmentation progressive tout au long de la grossesse.
Configurable clock service for time-aware IoT applications (2017)

The distribution of a common time reference is a well known problem in traditional measurement systems. The Internet of Things (IoT) scenario is characterized by an higher dynamism. A given device can be reconfigured for serving different applications, that may have different requirements in terms of synchronization accuracy. Therefore, it is not possible to define in advance the optimal solution. A challenging objective consists in realizing self-conscious devices, able to evaluate the accuracy of their time reference, choose among different synchronization protocols/systems, when available, and correctly set up protocol parameters to meet application requirements. A solution is discussed in this paper that outlines the concept of virtual clock as a local service by which an accurate time reference is provided to the requiring applications.
Fast Spin-Echo Inversion-Recovery Imaging versus Fast T2- Weighted Spin-Echo Imaging in Bone Marrow Abnormalities (1995)

Fast spin-echo STIR images may be preferable to FSE images with fat suppression due to better image homogeneity and lesion conspicuity.
Use of xanthan and its binary blends with synthetic polymers to design controlled release formulations of buccoadhesive nystatin tablets (2010)

Various buccoadhesive nystatin tablets formulations containing xanthan, carbopols (934P, 971P, 974P), PVP K30 or PEG 6000 or their binary blends were prepared. The powders were compressed into tablets at a constant compression pressure. Drug release behaviour, swelling and erosion indices and strength of bioadhesion in vitro to a biological membrane were investigated. The interaction between nystatin and polymers was investigated by DSC and FT-IR. Tablets containing the different types of carbopol alone consistently showed an initial burst release of drug, whereas this was not observed for matrices containing xanthan or xanthan-carbopol. The presence of PEG in xanthan-containing formulations induced an increase in dissolution rate; however, in the absence of xanthan the amount of drug release from a PEG matrix was reduced to < 15% over 8 h dissolution. The presence of PVP increased the dissolution rate of nystatin due to the relative hydrophilicity of PVP. The presence of calcium ions induced a more rigid gel in the xanthan matrix as a result of interaction between the polymer and calcium ions. Xanthan can be used in potential mucoadhesive formulations containing nystatin to produce a controlled release of the drug and the outcomes of this work may provide a suitable strategy for matrix selection to provide more efficacious treatment alternatives for candidiasis and other disease processes for significant patient populations.
Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments (2018)

Central Nervous System (CNS) diseases represent one of the most challenging therapeutic areas for successful drug approvals. Developing quantitative biomarkers as Drug Development Tools (DDTs) can catalyze the path to innovative treatments, and improve the chances of drug approvals. Drug development and healthcare management requires sensitive, reliable, validated, and regulatory accepted biomarkers and endpoints. This review highlights the regulatory paths and considerations for developing DDTs required to advance biomarker and endpoint use in clinical development (e.g., consensus CDISC [Clinical Data Interchange Standards Consortium] data standards, precompetitive sharing of anonymized patient-level data, and continual alignment with regulators). Summarized is the current landscape of biomarkers in a range of CNS diseases including Alzheimer disease, Parkinson Disease, Amyotrophic Lateral Sclerosis, Autism Spectrum Disorders, Depression, Huntington's disease, Multiple Sclerosis and Traumatic Brain Injury. Advancing DDTs for these devastating diseases that are both validated and qualified will require an integrated, cross-consortium approach to accelerate the delivery of innovative CNS therapeutics.
Does WoW Change Everything? (2006)

Rather than simply identifying “emergence” as a prime property of massively multiplayer online game life, a better understanding of the complex nature of player-produced culture is needed. Life in game worlds is not exempt from forms of player-based regulation and control. Drawing on ethnographic and interview work within World of Warcraft, the author undertakes initial inquiries on this subject by looking at three areas: nationalism, age, and surveillance. This case study shows systems of stratification and control can arise from the bottom up and be implemented in not only everyday play culture but even player-produced modifications to the game system itself. Due to the ways these systems may simultaneously facilitate play, there is often an ambivalent dynamic at work. This piece also prompts some methodological considerations. By discussing field site choice, the author argues that context is of utmost importance and needs to be more thoughtfully foregrounded within game studies.
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex (2010)

The conserved TREX mRNA export complex is known to contain UAP56, Aly, Tex1, and the THO complex. Here, we carried out proteomic analysis of immunopurified human TREX complex and identified the protein CIP29 as the only new component with a clear yeast relative (known as Tho1). Tho1 is known to function in mRNA export, and we provide evidence that CIP29 likewise functions in this process. Like the known TREX components, a portion of CIP29 localizes in nuclear speckle domains, and its efficient recruitment to mRNA is both splicing- and cap-dependent. We show that UAP56 mediates an ATP-dependent interaction between the THO complex and both CIP29 and Aly, indicating that TREX assembly is ATP-dependent. Using recombinant proteins expressed in Escherichia coli, we show that UAP56, Aly, and CIP29 form an ATP-dependent trimeric complex, and UAP56 bridges the interaction between CIP29 and Aly. We conclude that the interaction of two conserved export proteins, CIP29 and Aly, with UAP56 is strictly regulated by ATP during assembly of the TREX complex.
Comparative profiles of BRAF inhibitors: the paradox index as a predictor of clinical toxicity (2016)

// Charles H. Adelmann 1 , Grace Ching 1 , Lili Du 1 , Rachael C. Saporito 1 , Varun Bansal 1 , Lindy J. Pence 1 , Roger Liang 1 , Woojin Lee 1 , Kenneth Y. Tsai 1, 2, 3 1 Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA 2 Department of Dermatology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA 3 Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA Correspondence to: Kenneth Y. Tsai, email: kytsai@mdanderson.org Keywords: BRAF, squamous cell carcinoma, small molecule inhibitor, paradoxical ERK, melanoma Received: November 26, 2015&emsp;&emsp;&emsp;&emsp; Accepted: March 04, 2016&emsp;&emsp;&emsp;&emsp; Published: March 25, 2016 ABSTRACT BRAF inhibitor (BRAFi) therapy is associated with the induction of neoplasia, most commonly cutaneous squamous cell carcinoma (cuSCC). This toxicity is explained in part by &ldquo;paradoxical ERK activation,&rdquo; or the hyperactivation of ERK signaling by BRAFi in BRAF wild-type cells. However, the rate of cuSCC induction varies widely among BRAFi. To explore this mechanistically, we profiled paradoxical ERK activation by vemurafenib, dabrafenib, encorafenib (LGX818), and PLX8394, demonstrating that vemurafenib induces ERK activation the greatest, while dabrafenib and encorafenib have higher &ldquo;paradox indices&rdquo;, defined as the pERK activation EC 80 divided by the IC 80 against A375, corresponding to wider therapeutic windows for achieving tumor inhibition without paradoxical ERK activation. Our results identify differences in the paradox indices of these compounds as a potential mechanism for the differences in cuSCC induction rates and highlight the utility of using ERK activity as a biomarker for maximizing the clinical utility of BRAFi.
<title>Vision-based tracking system for control of convoys</title> (1994)

A simple vision based system to perform a contactless coupling, rather than a hardware hook is suggested. The method facilitates automatic convoy formation and management. The vision technique uses 3 landmarks and a CCD camera. Using a geometric approach that capitalizes the excellent angular resolution of CCD cameras, the position and orientation of the camera are estimated in respect to the landmarks. Experimental results show the reliability of the technique in operating contexts.
Ion exchanges in apatites. Effects on composition and properties (2005)

The modification of the composition of apatites materials can be made by several processes corresponding to ion exchange reactions which can conveniently be adapted to current coatings and ceramics and are an alternative to the set up of new synthesis methods. In addition to high temperature thermal treatments, which allow to virtually replace partly or totally monovalent OH anion of stoichiometric hydroxyapatite by any halogen ion or carbonate, aqueous processes corresponding to dissolution-reprecipitation reactions have also been proposed and used. The most interesting possibilities are however provided by aqueous ion exchange reactions involving nanocrystalline apatites. These apatites are characterised by the existence on the crystal surface of a hydrated layer of loosely bound mineral ions which can be easily exchanged in solution. This layer offers a possibility to trap mineral ions and possibly active molecules which can modify the apatite properties. Such processes are involved in mineralised tissues and could be used in biomaterials for the release of active mineral species.
Proton Model of a Heavy-Ion RFQ Linac (1981)

The radio frequency quadrupole (RFQ) structure has been accepted to be very well suited for the acceleration of light ions at high currents in the low energy range. In case of very heavy ions with low charge the structure is characterized by low r.f. frequencies in the 10 MHz range, and is therefore technically different. An RFQ accelerator at 13.5 MHz for the acceleration of U++ ions from 2.4 to 100 keV/amu has been designed. Problems like current transport capability, emittance growth, validity of calculations are presently studied using a 1:4 proton model.
Caching Transient Content for IoT Sensing: Multi-Agent Soft Actor-Critic (2021)

Edge nodes (ENs) in Internet of Things commonly serve as gateways to cache sensing data while providing accessing services for data consumers. This paper considers multiple ENs that cache sensing data under the coordination of the cloud. Particularly, each EN can fetch content generated by sensors within its coverage, which can be uploaded to the cloud via fronthaul and then be delivered to other ENs beyond the communication range. However, sensing data are usually transient with time whereas frequent cache updates could lead to considerable energy consumption at sensors and fronthaul traffic loads. Therefore, we adopt Age of Information to evaluate data freshness and investigate intelligent caching policies to preserve data freshness while reducing cache update costs. Specifically, we model the cache update problem as a cooperative multi-agent Markov decision process with the goal of minimizing the long-term average weighted cost. To efficiently handle the exponentially large number of actions, we devise a novel reinforcement learning approach, which is a discrete multi-agent variant of soft actor-critic (SAC). Furthermore, we generalize the proposed approach into a decentralized control, where each EN can make decisions based on local observations only. Simulation results demonstrate the superior performance of the proposed SAC-based caching schemes.
The Effects of High-Protein Diets on Kidney Health and Longevity (2020)

Although high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with-and perhaps without-impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to <i>de novo</i> CKD. The quality of dietary protein may also play a role in kidney health. Compared with protein from plant sources, animal protein has been associated with an increased risk of ESKD in several observational studies, including the Singapore Chinese Health Study. Potential mediators of kidney damage from animal protein include dietary acid load, phosphate content, gut microbiome dysbiosis, and resultant inflammation. In light of such findings, adopting current dietary approaches that include a high proportion of protein for weight reduction or glycemic control should be considered with care in those at high risk for kidney disease. Given the possibility of residual confounding within some observational studies and the conflicting evidence from previous trials, long-term studies including those with large sample sizes are warranted to better ascertain the effects of high protein intake on kidney health.
Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection (2020)

Liposomal delivery of prednisolone improved renal bio-availability, increased perfusion and reduced cellular infiltrate in the allograft, when compared with conventional prednisolone. Clinical studies should reveal if treatment with LP results in improved efficacy and reduced side effects in patients with renal allograft rejection.
Inpainting for Fringe Projection Profilometry Based on Geometrically Guided Iterative Regularization (2015)

Conventional fringe projection profilometry methods often have difficulty in reconstructing the 3D model of objects when the fringe images have the so-called highlight regions due to strong illumination from nearby light sources. Within a highlight region, the fringe pattern is often overwhelmed by the strong reflected light. Thus, the 3D information of the object, which is originally embedded in the fringe pattern, can no longer be retrieved. In this paper, a novel inpainting algorithm is proposed to restore the fringe images in the presence of highlights. The proposed method first detects the highlight regions based on a Gaussian mixture model. Then, a geometric sketch of the missing fringes is made and used as the initial guess of an iterative regularization procedure for regenerating the missing fringes. The simulation and experimental results show that the proposed algorithm can accurately reconstruct the 3D model of objects even when their fringe images have large highlight regions. It significantly outperforms the traditional approaches in both quantitative and qualitative evaluations.
Control of dynamic gaits for a quadrupedal robot (2013)

Quadrupedal animals move through their environments with unmatched agility and grace. An important part of this is the ability to choose between different gaits in order to travel optimally at a certain speed or to robustly deal with unanticipated perturbations. In this paper, we present a control framework for a quadrupedal robot that is capable of locomoting using several gaits. We demonstrate the flexibility of the algorithm by performing experiments on StarlETH, a recently-developed quadrupedal robot. We implement controllers for a static walk, a walking trot, and a running trot, and show that smooth transitions between them can be performed. Using this control strategy, StarlETH is able to trot unassisted in 3D space with speeds of up to 0.7m/s, it can dynamically navigate over unperceived 5-cm high obstacles and it can recover from significant external pushes.
Promising Tools to Facilitate the Implementation of TDM of Biologics in Clinical Practice (2022)

Therapeutic drug monitoring (TDM) of biologics-encompassing the measurement of (trough) concentrations and anti-drug antibodies-is emerging as a valuable tool for clinical decision making. While this strategy needs further validation, attention on its implementation into the clinic is warranted. Rapid testing and easy sampling are key to its implementation. Here, we aimed to evaluate the feasibility and volunteers' perception of home microsampling for quantification of adalimumab (ADM) concentrations in psoriasis patients. In addition, we compared lateral flow testing (LFT) with enzyme-linked immunosorbent assay (ELISA). Patients participating in the SUPRA-A study (clinicaltrials.gov NCT04028713) were asked to participate in a substudy where volumetric absorptive microsampling (VAMS) was performed at home. At three time points, whole blood and corresponding serum samples were collected for ADM measurement using an in-house ELISA. In addition, the patients' perspective on microsampling was evaluated via a questionnaire. LFT-obtained ADM concentrations agreed very well with ELISA results (Pearson's correlation = 0.95 and R<sup>2</sup> = 0.89). ADM concentrations determined in both capillary (via finger prick) and corresponding venous blood VAMS samples correlated strongly with serum concentrations (Pearson's correlation = 0.87). Our preliminary data (n = 7) on rapid testing and home-based microsampling are considered promising with regard to TDM implementation for adalimumab, warranting further research.