gebhart/patrepeval huggingface dataset:
Inducible Nitric Oxide Synthase Gene Expression in Vascular Cells After Transient Focal Cerebral Ischemia (1996)

Transient focal ischemia leads to iNOS expression in postischemic brain. However, the spatial and temporal patterns of expression differ from those occurring in permanent ischemia: iNOS is induced earlier and predominantly in vascular cells rather than in neutrophils. Thus, the temporal profile and localization of postischemic iNOS expression depend on the nature of the ischemic insult. The finding that aminoguanidine reduces infarct size adds further support to the hypothesis that postischemic iNOS expression contributes to ischemic brain damage.
Determination of nitrogen and oxygen functional groups in coal-derived asphaltenes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of nitrogen and oxygen functional groups in coal-derived asphaltenesIrving. Schwager and Teh Fu. YenCite this: Anal. Chem. 1979, 51, 4, 569–571Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ac50040a028https://doi.org/10.1021/ac50040a028research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tri-training: exploiting unlabeled data using three classifiers (2005)

In many practical data mining applications, such as Web page classification, unlabeled training examples are readily available, but labeled ones are fairly expensive to obtain. Therefore, semi-supervised learning algorithms such as co-training have attracted much attention. In this paper, a new co-training style semi-supervised learning algorithm, named tri-training, is proposed. This algorithm generates three classifiers from the original labeled example set. These classifiers are then refined using unlabeled examples in the tri-training process. In detail, in each round of tri-training, an unlabeled example is labeled for a classifier if the other two classifiers agree on the labeling, under certain conditions. Since tri-training neither requires the instance space to be described with sufficient and redundant views nor does it put any constraints on the supervised learning algorithm, its applicability is broader than that of previous co-training style algorithms. Experiments on UCI data sets and application to the Web page classification task indicate that tri-training can effectively exploit unlabeled data to enhance the learning performance.
Recent advances in head and neck cancer: The beginning of the immunotherapy era in HNSCC (2018)

After bringing unprecedented clinical benefits to patients with advanced melanoma, the field of immunotherapy has continued to break new ground and progressively transform the therapeutic landscape across many other cancers. The American Society of Clinical Oncology (ASCO), acknowledging the transformative impact and future potential of immunotherapy, has named it the “Advance of the Year” for the second consecutive year.
Near Field Active Imaging Using Sparse Arrays (2018)

Sensor arrays designed for far field operation may experience performance degradation when imaging near field objects. Specifically, sparse active arrays utilizing the additional degrees of freedom provided by the sum co-array are susceptible to these effects, as the co-array depends on both the range and direction of scatterers close to the array. Consequently, a uniform far field sum co-array may become non-uniform in the near field. As a result, co-array processing algorithms, such as image addition, are subject to undesired grating lobes in the presence of near field scatterers. This paper proposes an extension to image addition for mitigating such undesired distortions. The method compensates for near field effects by computing spatially varying transmit and receive element weights. These weights minimize the discrepancy between the desired and achieved near field point spread function, while using as few image addition components as possible. Given a desired point spread function and a set of calibration measurements of the near field array steering vectors, a regularized convex optimization problem is then solved for each pixel of the image.
Strong organometallic anomeric effects. Long-range stereoelectronic control of cyclohexanone conformation via a transannular metallacyclobutane interaction (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStrong organometallic anomeric effects. Long-range stereoelectronic control of cyclohexanone conformation via a transannular metallacyclobutane interactionErik B. Tjaden, Kathryn E. Schwiebert, and Jeffrey M. StrykerCite this: J. Am. Chem. Soc. 1992, 114, 3, 1100–1102Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ja00029a056https://doi.org/10.1021/ja00029a056research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Listening to your turbines (1991)

Cavitation is something hydro plant owners can't afford to ignore. A new technique using acoustic emissions can detect and monitor cavitation in its early stages, and thus serve as a guide for maintenance scheduling and operational changes. In the mid-1980s, the Electric Power Research Institute (EPRI) sponsored a feasibility study in which full-wave rectification spectral analysis was applied to two Kaplan turbines to process the sound emanating from cavitating blades. (In full-wave rectification spectral analysis, the system electronically manipulates the sound signal in order to bring out certain frequencies - in this case, those associated with cavitation. It is based on a phenomenon similar to the amplitude modulation in an AM radio signal, where a high frequency carrier wave is modulated by the lower frequencies of the sounds being broadcast). The study showed the approach to be a viable means of detecting the onset and severity of cavitation. The Institut de Recherche d'Hydro-Quebec (IREQ) also explored the potential of full-wave rectification spectral analysis in monitoring cavitation in hydroturbines in the mid-1980s. Its study, sponsored by the Canadian Electrical Association, focused on model and full-scale Francis turbines. The IREQ researchers confirmed the applicability of the method used in the EPRI studymore » to large-scale Francis turbines.« less
A zero voltage switching and self-reset forward converter topology (1999)

A zero voltage switching (ZVS) forward converter topology is presented in this paper. In this topology, an auxiliary circuit is employed. ZVS is achieved on both the main and auxiliary switches. The power transformer in the proposed topology is self-reset without the use of a conventional tertiary reset winding. Analysis and design of the circuit are presented. Experiments on a 5 V, 100 W prototype converter switched at a frequency of 200 kHz verify the design and show an overall efficiency of about 90%.
Data from Cyclin E Deregulation Impairs Mitotic Progression through Premature Activation of Cdc25C (2023)

&lt;div&gt;Abstract&lt;p&gt;The cyclin E–cyclin-dependent kinase 2 (CDK2) complex accelerates entry into the S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells. The effect of low molecular weight isoforms of cyclin E (LMW-E) overexpression on mitotic progression and its link to genomic instability were the focus of this study. Here, we show that full-length cyclin E (EL) and LMW-E overexpression impairs the G&lt;sub&gt;2&lt;/sub&gt;-M transition differently by targeting dual-specificity phosphatase Cdc25C activity. We identify Cdc25C as an interaction partner and substrate for cyclin E/CDK2 kinase. Specifically, the cyclin E/CDK2 complex phosphorylates Cdc25C on Ser&lt;sup&gt;214&lt;/sup&gt;, leading to its premature activation, which coincides with higher cyclin B/CDK1 and Polo-like kinase 1 (PLK1) activities in an S-phase–enriched population that result in faster mitotic entry. Whereas EL overexpression leads to hyperactivation of Cdc25C, cyclin B/CDK1, and PLK1 in a G&lt;sub&gt;2&lt;/sub&gt;-M–enriched population, LMW-E overexpression causes premature inactivation of Cdc25C and PLK1, leading to faster mitotic exit. In addition, LMW-E–overexpressing cells showed a reduction in the mitotic index in the presence of a spindle poison and faster degradation of cyclin B, suggesting an increased rate of mitotic slippage and adaptation to the spindle checkpoint. Lastly, downregulation of Cdc25C inhibits LMW-E–mediated chromosome missegregation, anaphase bridges, and centrosome amplification. These results suggest that the high levels of LMW-E isoforms found in breast cancer may contribute to cellular transformation and genomic instability by impairing mitotic progression involving Cdc25C. Cancer Res; 70(12); 5085–95. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
A linear filtering approach to the computation of discrete Fourier transform (1970)

It is shown in this paper that the discrete equivalent of a chirp filter is needed to implement the computation of the discrete Fourier transform (DFT) as a linear filtering process. We show further that the chirp filter should not be realized as a transversal filter in a wide range of cases; use instead of the conventional FFT permits the computation of the DFT in a time proportional to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N \log_{2} N</tex> for any <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N, N</tex> being the number of points in the array that is transformed. Another proposed implementation of the chirp filter requires N to be a perfect square. The number of operations required for this algorithm is proportional to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N^{3/2}</tex> .
Synthesis and X-Ray Crystal Structure of the First Pure and Air-Stable Salt of Peroxymonosulphuric Acid: (Ph)4PHSO5 (2000)

In this paper we describe the synthesis of tetraphenylphosphonium peroxymonosulphate, its crystal structure and packing mode. The asymmetric unit accomodates two independent molecules of the monopersulphate anion, which are held together by hydrogen bonds. In the packing mode, rows of such dimers are surrounded by four rows of tetraphenyl cations. The consequence is that the highly water sensitive HSO5¯ anions are segregated inside hydrophobic channels composed by the lipophilic cations. This circumstance presumably accounts for the exceptional stability of the title compound.
Production and optimization of carotenoid-enriched dried distiller’s grains with solubles by Phaffia rhodozyma and Sporobolomyces roseus fermentation of whole stillage (2010)

Whole stillage--a co-product of grain-based ethanol--is used as an animal feed in the form of dried distiller's grain with solubles (DDGS). Since animals cannot synthesize carotenoids and animal feed is generally poor in carotenoids, about 30-120 ppm of total carotenoids are added to animal feed to improve animal health, enhance meat color and quality, and increase vitamin A levels in milk and meat. The main objective of this study was to produce carotenoid (astaxanthin and β-carotene)-enriched DDGS by submerged fermentation of whole stillage. Mono- and mixed cultures of red yeasts, Phaffia rhodozyma (ATCC 24202) and Sporobolomyces roseus (ATCC 28988), were used to produce astaxanthin and β-carotene. Media optimization was carried out in shake flasks using response surface methodology (RSM). Macro ingredients, namely whole stillage, corn steep liquor and glycerol, were fitted to a second-degree polynomial in RSM. Under optimized conditions, astaxanthin and β-carotene yields in mixed culture and P. rhodozyma monoculture were 5 and 278, 97, and 275 μg/g, respectively, while S. roseus produced 278 μg/g of β-carotene. Since the carotenoid yields are almost twice the quantity used in animal feed, the carotenoid-enriched DDGS has potential application as "value-added animal feed or feed blends."
Impact of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement on Changes in Cardiac Sympathetic Nervous Function (2020)

The impact of prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) on changes in cardiac sympathetic nervous (CSN) function remains unclear. Using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, we investigated the impact of PPM after TAVR on CSN activity.We enrolled 44 of 117 patients with severe aortic stenosis who underwent TAVR for analysis in the present study. We conducted 123I-MIBG scintigraphy at baseline and at about 9 months after TAVR. Differences between baseline and post-TAVR 123I-MIBG parameters were compared between cases with and without PPM.There were 17 and 27 patients with and without PPM, respectively. Those without PPM exhibited significantly decreased left ventricular mass index (122 ± 36 g/m<sup>2</sup> versus 108 ± 30 g/m<sup>2</sup>, P < 0.001) following TAVR, whereas those with PPM did not (117 ± 21 g/m<sup>2</sup> versus 110 ± 17 g/m<sup>2</sup>, P = 0.09). Significant improvements in delayed heart-to-mediastinum (H/M) ratio (2.8 ± 0.4 versus 3.0 ± 0.4, P = 0.004) and washout rate (WR) (33% ± 10% versus 24% ± 12%, P < 0.001) were observed after TAVR in patients without PPM but not in those with PPM. Multivariable linear regression analysis revealed PPM to be a negative predictor of improvements in delayed H/M ratio and WR.Delayed H/M ratio and WR improve significantly after TAVR in the absence of PPM, whereas these improvements are not observed in patients with PPM. Hence, the presence of PPM is a negative predictor of improvements in delayed H/M ratio and WR in patients undergoing TAVR.
Large scale Optimal Transportation Meshfree (OTM) Simulations of Hypervelocity Impact (2013)

Large scale three-dimensional numerical simulations of hypervelocity impact of Aluminum alloy 6061-T6 plates by Nylon 6/6 cylindrical projectile have been performed using the Optimal Transportation Meshfree (OTM) method of Li et al. [7] along with the seizing contact and variational material point failure algorithm [17], [18]. The dynamic response of the Al6061-T6 plate including phase transition in the high strain rate, high pressure and high temperature regime expected in our numerical analysis is described by the use of a variational thermomechanical coupling constitutive model with SESAME equation of state, rate-dependent J2 plasticity with power law hardening and thermal softening and temperature dependent Newtonian viscosity. A polytropic type of equation of state fit to in-house ReaxFF calculations is employed to model the Nylon 6/6 projectile under extreme conditions. The evaluation of the performance of the numerical model takes the form of a conventional validation analysis. In support of the analysis, we have conducted experiments over a range of plate thicknesses of [0.5, 3.0] mm, a range of impact velocities of [5.0, 7.0]km/s and a range of obliquities of [0,70]o at Caltech's Small Particle Hypervelocity Range (SPHIR) Facility. Large scale three-dimensional OTM simulations of hypervelocity impact are performed on departmental class systems using a dynamic load balancing MPI/PThreads parallel implementation of the OTM method. We find excellent full field agreement between measured and computed perforation areas, debris cloud and temperature field.
Synthesis of N, F and S co-doped graphene quantum dots (2015)

Graphene quantum dots (GQDs) are a promising category of materials with remarkable size dependent properties like tunable bandgap and photoluminescence along with the possibility of effective chemical functionalization. Doping of GQDs with heteroatoms is an interesting way of regulating their properties. Herein, we report a facile and scalable one-step synthesis of luminescent GQDs, substitutionally co-doped with N, F and S, of ∼2 nm average size by a microwave treatment of multi-walled carbon nanotubes in a customized ionic liquid medium. The use of an ionic liquid coupled with the use of a microwave technique enables not only an ultrafast process for the synthesis of co-doped GQDs, but also provides excellent photoluminescence quantum yield (70%), perhaps due to the interaction of defect clusters and dopants.
A New Cyclization Reactions Cascade: Ene Type, [2 + 2 + 2], [4 + 2]. Stereoselective Formation of Six Carbon-Carbon Bonds and Four Rings in a One-Pot Sequence (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Cyclization Reactions Cascade: Ene Type, [2 + 2 + 2], [4 + 2]. Stereoselective Formation of Six Carbon-Carbon Bonds and Four Rings in a One-Pot SequencePaul Cruciani, Corinne Aubert, and Max MalacriaCite this: J. Org. Chem. 1995, 60, 9, 2664–2665Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/jo00114a010https://doi.org/10.1021/jo00114a010research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis (2008)

The chimeric monoclonal antibody rituximab is the standard of care for patients with B-cell non-Hodgkin lymphoma (B-NHL). Rituximab mediates complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity of CD20-positive human B cells. In addition, rituximab sensitizes B-NHL cells to cytotoxic chemotherapy and has direct apoptotic and antiproliferative effects. Whereas expression of the CD20 antigen is a natural prerequisite for rituximab sensitivity, cell-autonomous factors determining the response of B-NHL to rituximab are less defined. To this end, we have studied rituximab-induced apoptosis in human B-NHL models. We find that rituximab directly triggers apoptosis via the mitochondrial pathway of caspase activation. Expression of antiapoptotic Bcl-xL confers resistance against rituximab-induced apoptosis in vitro and rituximab treatment of xenografted B-NHL in vivo. B-NHL cells insensitive to rituximab-induced apoptosis exhibit increased endogenous expression of multiple antiapoptotic Bcl-2 family proteins, or activation of phosphatidylinositol-3-kinase signaling resulting in up-regulation of Mcl-1. The former resistance pattern is overcome by treatment with the BH3-mimetic ABT-737, the latter by combining rituximab with pharmacologic phosphatidylinositol-3-kinase inhibitors. In conclusion, sensitivity of B-NHL cells to rituximab-induced apoptosis is determined at the level of mitochondria. Pharmacologic modulation of Bcl-2 family proteins or their upstream regulators is a promising strategy to overcome rituximab resistance.
Super-resolution near-field ptychography (2020)

Compared to far-field ptychography, near-field ptychography can reduce the requirement on the detector dynamic range, while it is able to cover a larger field of view with a fewer number of sample scans. However, its spatial resolution is limited by the detector pixel size. Here, we utilize a pixel-super-resolved approach to overcome this limitation. The method has been applied to four types of experiment configurations using planar and divergent illuminations together with two different cameras with highly contrast specifications. The proposed method works effectively for up-sampling up to 6 times. Meanwhile, it can achieve ∼5.9-fold and ∼3.1-fold resolution improvement over the 6.5-μm and 2.4-μm detector pixel size. We also demonstrate the precisely quantitative phase imaging capability of the method by using a phase resolution target. The presented method is believed to have great potential in X-ray tomography and on-chip flow cytometry.