gebhart/patrepeval huggingface dataset:
Altered expression of CXCR3 and CCR6 and their ligands in HTLV‐1 carriers and HAM/TSP patients (2017)

Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV-1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6, and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects. The PVL of HAM/TSP patients was higher than that of ACs (P = 0.02). CCR6 expression was higher in HAM/TSP patients and in ACs compared to the healthy controls (P = 0.005 and P = 0.04, respectively). A significant difference was observed in CCR6 expression when a combination of HAM/TSP patients and ACs were compared to the healthy individuals (P = 0.005). Furthermore, there was a significantly lower CXCR3 expression between HAM/TSP and control groups (P = 0.001), and between the ACs and healthy controls (P = 0.001). However, the increased CXCR3 expression in ACs compared to HAM/TSP patients was not significant. Furthermore, the CXCL10 protein levels in HAM/TSP patients was higher than in controls (P = 0.012), and CXCL9 protein levels was also higher in the HAM/TSP and ACs groups than in the controls (P = 0.001 and P = 0.004, respectively). In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Room-temperature Cu(ii)-catalyzed aromatic C–H azidation for the synthesis of ortho-azido anilines with excellent regioselectivity (2014)

Cu(ii)-catalyzed aromatic C-H azidation with azido-benziodoxolone under mild conditions has been described. The primary amine exhibits an excellent ortho-directing effect, providing ortho-azidated anilines as the sole products.
Probing Floquet modes in a time periodic system with time defects using Faraday instability (2020)

Abstract Time crystals are systems whose properties are periodically modulated in time. Among these, Floquet time crystals exhibit momentum gaps in their band structures, analogous to energy gaps in spatial crystals. Recently, time defects with a -shift in the time modulation have been introduced theoretically as temporal analogues of spatial topological defects associated with localized edge modes. Here we perform experiments in a time periodic system using Faraday instability, a parametric excitation of a liquid bath by vertical shaking. Although time defects also trigger an exponentially decaying wave, we show that the analogy does not hold due to temporal causality and lack of energy conservation. However, these time defects provide an original way to explore momentum gaps and reveal their overdamped modes.
Robust Federated Learning for execution time-based device model identification under label-flipping attack (2023)

Abstract The computing device deployment explosion experienced in recent years, motivated by the advances of technologies such as Internet-of-Things (IoT) and 5G, has led to a global scenario with increasing cybersecurity risks and threats. Among them, device spoofing and impersonation cyberattacks stand out due to their impact and, usually, low complexity required to be launched. To solve this issue, several solutions have emerged to identify device models and types based on the combination of behavioral fingerprinting and Machine/Deep Learning (ML/DL) techniques. However, these solutions are not appropriate for scenarios where data privacy and protection are a must, as they require data centralization for processing. In this context, newer approaches such as Federated Learning (FL) have not been fully explored yet, especially when malicious clients are present in the scenario setup. The present work analyzes and compares the device model identification performance of a centralized DL model with an FL one while using execution time-based events. For experimental purposes, a dataset containing execution-time features of 55 Raspberry Pis belonging to four different models has been collected and published. Using this dataset, the proposed solution achieved 0.9999 accuracy in both setups, centralized and federated, showing no performance decrease while preserving data privacy. Later, the impact of a label-flipping attack during the federated model training is evaluated using several aggregation mechanisms as countermeasures. Zeno and coordinate-wise median aggregation show the best performance, although their performance greatly degrades when the percentage of fully malicious clients (all training samples poisoned) grows over 50%.
Lambda, the ultimate label or a simple optimizing compiler for Scheme (1994)

Optimizing compilers for higher-order languages need not be terribly complex. The problems created by non-local, non-global variables can be eliminated by allocating all such variables in the heap. Lambda lifting makes this practical by eliminating all non-local variables except for those that would have to be allocated in the heap anyway. The eliminated non-local variables become local variables that can be allocated in registers. Since calls to known procedures are just gotos that pass arguments, lifted lambda expressions are just assembly language labels that have been augmented by a list of symbolic names for the registers that are live at that label.
Electron spin resonance spectroscopic study of electronic charge transport in an aromatic diamine (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron spin resonance spectroscopic study of electronic charge transport in an aromatic diamineRichard P. Veregin and John R. HarbourCite this: J. Phys. Chem. 1990, 94, 16, 6231–6237Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/j100379a016https://doi.org/10.1021/j100379a016research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Timed pipeline templates (2010)

It is possible to achieve higher performance with pipelined templates by applying timing assumptions rather than designing them to be quasi-delay-insensitive. In fact, designing templates with assumptions on the relative order of certain signal transitions can not only speed up the operation of the circuit but also lower area and power consumption.
Technology for Automation of Weed Control in Specialty Crops (2016)

Specialty crops, like flowers, herbs, and vegetables, generally do not have an adequate spectrum of herbicide chemistries to control weeds and have been dependent on hand weeding to achieve commercially acceptable weed control. However, labor shortages have led to higher costs for hand weeding. There is a need to develop labor-saving technologies for weed control in specialty crops if production costs are to be contained. Machine vision technology, together with data processors, have been developed to enable commercial machines to recognize crop row patterns and control automated devices that perform tasks such as removal of intrarow weeds, as well as to thin crops to desired stands. The commercial machine vision systems depend upon a size difference between the crops and weeds and/or the regular crop row pattern to enable the system to recognize crop plants and control surrounding weeds. However, where weeds are large or the weed population is very dense, then current machine vision systems cannot effectively differentiate weeds from crops. Commercially available automated weeders and thinners today depend upon cultivators or directed sprayers to control weeds. Weed control actuators on future models may use abrasion with sand blown in an air stream or heating with flaming devices to kill weeds. Future weed control strategies will likely require adaptation of the crops to automated weed removal equipment. One example would be changes in crop row patterns and spacing to facilitate cultivation in two directions. Chemical company consolidation continues to reduce the number of companies searching for new herbicides; increasing costs to develop new herbicides and price competition from existing products suggest that the downward trend in new herbicide development will continue. In contrast, automated weed removal equipment continues to improve and become more effective.
Optimizing Energy Efficiency for Minimum Latency Broadcast in Low-Duty-Cycle Sensor Networks (2015)

Multihop broadcasting in low-duty-cycle Wireless Sensor Networks (WSNs) is a very challenging problem, since every node has its own working schedule. Existing solutions usually use unicast instead of broadcast to forward packets from a node to its neighbors according to their working schedules, which is, however, not energy efficient. In this article, we propose to exploit the broadcast nature of wireless media to further save energy for low-duty-cycle networks, by adopting a novel broadcasting communication model. The key idea is to let some early wake-up nodes postpone their wake-up slots to overhear broadcasting messages from its neighbors. This model utilizes the spatiotemporal locality of broadcast to reduce the total energy consumption, which can be essentially characterized by the total number of broadcasting message transmissions. Based on such model, we aim at minimizing the total number of broadcasting message transmissions of a broadcast for low-duty-cycle WSNs, subject to the constraint that the broadcasting latency is optimal. We prove that it is NP-hard to find the optimal solution, and design an approximation algorithm that can achieve a polylogarithmic approximation ratio. Extensive simulation results show that our algorithm outperforms the traditional solutions in terms of energy efficiency.
Unicompartmental knee arthroplasty. Clinical experience at 6- to 10-year followup. (1999)

Sixty-two consecutive cemented modular unicompartmental knee arthroplasties in 51 patients were studied prospectively. At surgery, the other compartments had at most Grade 2 chondromalacia. The average age of the patients at arthroplasty was 68 years (range, 51-84 years). One patient was lost to followup and 10 died with less than 6 years followup. The average followup of the remaining 51 knees was 7.5 years (range, 6-10 years). The preoperative Hospital for Special Surgery knee score of 55 points (range, 30-79 points) improved to 92 points (range, 60-100 points) at followup; 78% (40 knees) had excellent and 20% (10 knees) had good results. The mean range of motion at followup was 120 degrees with 26 knees (51%) having range of motion greater than 120 degrees. One patient underwent revision surgery for retained cement, one patient underwent knee manipulation, and one patient underwent revision surgery at 7 years for opposite compartment degeneration and pain. Radiographically, 26 knees (51%) had at least one partial radiolucency. There were no complete femoral radiolucencies, but there were three complete tibial radiolucencies, all less than 2 mm. No component was loose as seen on radiographs. At final followup, five of the opposite compartments (10%) and three of the patellofemoral joints (6%) had some progressive radiographic joint space loss; this was less than a 25% loss in all but one knee component that was revised. At 6- to 10-years followup, cemented unicompartmental knee arthroplasty yielded excellent clinical and radiographic results. The 10-year survival using radiographic loosening or revision as the end point was 98%. Using stringent selection criteria, unicompartmental knee replacement can yield excellent results and represents a superb alternative to total knee replacement.
Combining Pedagogical Methods with Hands-On Chemistry Demonstrations (2019)

Master of Education students at The Ohio State University have the opportunity to participate in a collaborative class called “Methods in Teaching Secondary Science Part II.” This program partners faculty from education, chemistry, physics, earth and space science, life science, and engineering. Pre-service teachers work with these experts on projects geared toward preparing them to teach science in grade 7– 12 schools. The chemistry module focuses on using chemical demonstrations in a classroom setting to facilitate learning and to explore Next Generation Science Standards (NGSS) topics and methods. Demonstrations are chosen from a curated list, many of which are easily obtained or constructed by teachers. The Methods students give presentations to their peers, which are filmed and used for feedback and inclusion in the students’ teaching portfolios.
Tramadol and acetaminophen tablets for dental pain. (2001)

The purpose of this work was to compare the efficacy and time to analgesia of a new tramadol/acetaminophen combination tablet to those of tramadol or acetaminophen (APAP) alone. A meta-analysis was performed of 3 separate single-dose, double-blind, parallel-group trials in patients with moderate or severe pain following extraction of 2 or more third molars. Patients in each study were evenly randomized to a single dose of tramadol/APAP (75 mg/650 mg), tramadol 75 mg, APAP 650 mg, ibuprofen 400 mg, or placebo. Active control with ibuprofen was used to determine model sensitivity. Pain relief (scale, 0-4) and pain intensity (scale, 0-3) were reported at 30 minutes after the dose and then hourly for 8 hours. Total pain relief over 8 hours (TOTPAR8) and the sum of pain intensity differences (SPID8) were calculated from the hourly scores. Time to onset of pain relief was determined by the double-stopwatch technique, and patients were advised to wait at least 2 hours before taking supplemental analgesia. Patients assessed overall efficacy (scale, 1-5) upon completion. In all, 1197 patients (age range, 16-46 years) were evaluable for efficacy; treatment groups in each study were similar at baseline. Pain relief was superior to placebo (P < or = .0001) for all treatments. Pain relief provided by tramadol/ APAP was superior to that of tramadol or APAP alone, as shown by mean TOT-PAR8 (12.1 vs 6.7 and 8.6, respectively, P < or = .0001) and SPID8 (4.7 vs 0.9 and 2.7, respectively, P < or = .0001). Estimated onset of pain relief was 17 minutes (95% CI, 15-20 minutes) for tramadol/APAP compared with 51 minutes (95% CI, 40-70 minutes) for tramadol, 18 minutes (95% CI, 16-21 minutes) for APAP, and 34 minutes (95% CI, 28-44 minutes) for ibuprofen. Median time to supplemental analgesia and mean overall assessment of efficacy were greater (P < .05) for the tramadol/APAP group (302 minutes and 3.0, respectively) than for the tramadol (122 minutes and 2.0) or APAP (183 minutes and 2.7) monotherapy groups. A new combination analgesic, tramadol/APAP, is superior to tramadol or APAP alone with respect to pain relief and duration of action. It is also superior to tramadol alone with respect to time to onset.
Negative Regulation of the RelA/p65 Transactivation Function by the Product of the DEK Proto-oncogene (2006)

NF-kappaB-mediated transcriptional activation is controlled at several levels including interaction with coregulatory proteins. To identify new proteins capable of modulating NF-kappaB-mediated activation, a cytoplasmic two-hybrid screen was performed using the p65 C-terminal transactivation domain as bait and identified the product of the DEK proto-oncogene. DEK is a ubiquitous nuclear protein that has been implicated in several types of cancer and autoimmune diseases. DEK appears to function in several nuclear processes including transcriptional repression and modulation of chromatin structure. Our data indicate that DEK functions as a transcriptional corepressor to repress NF-kappaB activity. DEK expression blocked p65-mediated activation of an NF-kappaB-dependent reporter gene and also inhibited TNFalpha-induced activation of the reporter gene. Chromatin Immunoprecipitation (ChIP) assays showed that DEK associates with the promoters of the NF-kappaB-regulated cIAP2 and IL-8 genes in untreated cells and dissociates from these promoters upon NF-kappaB binding in response to TNFalpha treatment. Moreover, the expression levels of an NF-kappaB-dependent reporter gene as well as the NF-kappaB-regulated Mcp-1 and IkappaBalpha genes is increased in DEK-/- cells compared with wild-type cells. ChIP assays on these promoters show enhanced and prolonged binding of p65 and increased recruitment of the P/CAF coactivator. Overall, these data provide further evidence that DEK functions to negatively regulate transcription.
Metal oxide electrocatalyst support for carbon-free durable electrodes with excellent corrosion resistance at high potential conditions (2021)

Corrosion-resistive conductive titanium oxide exhibited remarkably higher durability than a carbon support during electrochemical catalytic reactions under high potential conditions.
Correction: Use of biomaterials for sustained delivery for anti-VEGF to treat retinal diseases (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A novel side-wall transfer-transistor cell (SWATT cell) for multi-level NAND EEPROMs (2002)

A multi-level NAND Flash memory cell, using a new Side-WAll Transfer-Transistor (SWATT) structure, has been developed for a high performance and low bit cost Flash EEPROM. With the SWATT cell, a relatively wide threshold voltage (Vth) distribution of about 1.1 V is sufficient for a 4-level memory cell in contrast to a narrow 0.6 V distribution that is required for a conventional 4-level NAND cell. The key technology that allows this wide Vth is the Transfer Transistor which is located at the side wall of the Shallow Trench Isolation (STI) region and is connected in parallel with the floating gate transistor. During read, the Transfer Transistors of the unselected cells (connected in series with the selected cell) function as pass transistors. So, even if the Vth of the unselected floating gate transistor is higher than the control gate voltage, the unselected cell will be in the ON state. As a result, the Vth distribution of the floating gate transistor can be wider and the programming can be faster because the number of program/verify cycles can be reduced. Furthermore, the SWATT cell realizes a very small cell size of 0.67 /spl mu/m/sup 2/ for a 0.35 /spl mu/m rule. Thus, the SWATT cell combines a small cell size with a multi-level scheme to realize a very low bit cost. This paper describes the process technology and the device performance of the SWATT cell, which can be used to realize NAND EEPROMs of 512 Mbit and beyond.
Using code mobility to create ubiquitous and active augmented reality in mobile computing (1999)

The concept augmented realie is used to describe a system that supplements reality by adding virtual objects into a real-world view. This paper describes a flexible mobile code approach that we can use to implement ubiquitous, active, and mobile augmented reality systems. We will concentrate primarily on solving the problem of how to acquire the data for the virtual objects in a way that will be flexible and expandable enough to be used in truly ubiquitous computer systems. To clarify the concept, we will present an example system that provides virtual user interfaces for various real-world objects. This paper suggests that the mobile code approach offers a relatively simple solution that is flexible, scales well, and does not require the computing equipment attached to the real-world objects to be excessively complicated. We can use the same mobile code approach in applications that provide only simple descriptions of the real-world objects and in complex applications that allow the user to manipulate real-world objects via virtual user interfaces that exist only in augmented reality. Our approach also supports active augmented reality, in which the virtual objects can react to the real-world events.
Lake Ecology and Chemistry (2015)

We present an overview of the main physical, chemical and ecological features of lake ecosystems. The main aim is to briefly address the complexity of this subject. The solute composition of lake water depends upon a number of interplaying factors, including the watershed geology, land uses, climate, pollution sources, thermal regime and biota. Excess nutrients (N and P) from diffuse or point sources may trigger eutrophication processes, resulting in algal blooms and oxygen shortage. For this reason, a great wealth of studies has been performed on the causal factors and effects of eutrophication and possible remedial measures. In recent decades, P loadings from point sources decreased due to the enforcement of strong environmental policies, e.g. the implementation of wastewater treatment plants. Nonetheless, the restoration of pristine conditions has not yet been achieved because P may be recycled in large amounts from anoxic sediments, thus providing an internal source. Nitrogen loadings decreased proportionally less, mostly due to land use and diffuse pollution from agriculture and livestock, leading to new and challenging issues, e.g. the combined stoichiometry of N, P and Si as a driving factor of lake productivity and the food web. In the last two decades, studies on dissolved organic carbon have assumed a growing importance. This source of organic carbon fuels microbial communities and heterotrophic activity, with side effects on carbon dioxide emissions. The bulk of dissolved molecules composing this organic pool may also support planktonic production. Finally, they have optical properties, which are largely unexplored for their effects on lake ecology.
Columnar liquid-crystalline assemblies of X-shaped pyrene–oligothiophene conjugates: photoconductivities and mechanochromic functions (2016)

The self-assembly of X-shaped pyrene–oligothiophene conjugated molecules results in the formation of columnar liquid-crystalline structures that exhibit hole carrier transport properties and shear-induced phase transition accompanied by the luminescent colour change.
Scalable video streaming over P2P networks: A matter of harmony? (2011)

In this paper we address the problem of efficient layered video streaming over peer-to-peer networks and we propose a new receiver-driven streaming mechanism. The main design goal of our new layered video requesting policy is to optimize the overall distribution of video streams in terms of reliability and overhead. Since the layered peer-to-peer streaming problem is NP-Hard, we show that the classic approaches widely used in layered P2P streaming systems have some limitations and we propose an optimization technique based on harmony search which aims at increasing the rate of successful data transmissions for the most important video layers, while reducing the protocol overhead and ensuring load balancing among the participating peers. Analytical results have demonstrated that our new requesting policy enhances the streaming of layered video over mesh-based peer-to-peer networks and outperforms classic approaches.