gebhart/patrepeval huggingface dataset:
Correction to: “Experimental, DFT and QSAR models for the discovery of new pyrazines corrosion inhibitors for steel in oilfield acidizing environment” [Int. J. Electrochem. Sci., 15 (2020) 9066 - 9080; doi: 10.20964/2020.09.72] (2020)

The authors regret that there were errors in the original published version.
EDUCAÇÃO SEXUAL NA ESCOLA: CONSTRUÇÃO E APLICAÇÃO DE MATERIAL DE APOIO (2011)

Desenvolver a tematica da sexualidade na escola, alem de ser um desafio para os professores, exige coragem para pensar e abordar um tema delicado em sala de aula e conhecimento tecnico. O objetivo deste trabalho e apresentar uma experiencia de elaboracao e aplicacao de uma cartilha sobre sexualidade para ser utilizada como recurso didatico na escola, visando servir para iniciar e/ou fortalecer a aproximacao entre alunos, professores, pais/responsaveis e profissionais da saude. Os dados foram coletados a partir de uma ficha de avaliacao e analisados pela tecnica de analise de conteudo. A partir das discussoes dos resultados, concluimos que este tipo de recurso didatico contribui para o desenvolvimento desta tematica, esclarecendo duvidas, auxiliando na introducao e/ou no desenvolvimento de varios temas relacionados a sexualidade na escola, em casa ou no posto de saude, possibilitando uma maior aproximacao e integracao dos alunos com os adultos de referencia.
High level functional verification closure (2003)

We present a methodology to obtain high level functional verification closure. We discuss the current advances in critical technologies that are part of the verification closure solution. Within this methodology, assertion specifications are the starting point and central to the collaboration required between various verification tasks to efficiently search for tests and allow automation to proceed. The goal of verification closure is to generate a complete set of tests that meet the design quality criteria established for the design.
Research data supporting "An orthogonal biocatalytic approach for the safe generation and use of HCN in a multi-step continuous preparation of chiral O-acetylcyanohydrins" (2015)

Batch procedure for the CalB-catalyzed hydrolysis of ethyl cyanoformate (ECF). Flow procedure for the CalB-catalyzed hydrolysis of ethyl cyanoformate (ECF). Procedure for the immobilization of AtHNL on Celite. Procedure for the preparation of E. coli-AtHNL- and purification. Estimation of AtHNL content in lyophilized E. coli. Gene sequence for His6-AtHNL. Batch procedure for the synthesis of (R)-mandelonitrile. Synthesis of (R)-mandelonitrile by two-step (CalB-Celite-AtHNL) procedure in flow. Synthesis of (R)-mandelonitrile by two-step (CalB-E. coli-AtHNL) procedure in flow. Batch procedure for the synthesis of racemic O-acetylcyanohydrins. p. 8 S12. General flow procedure for the three-step cascade synthesis of (R)-O-acetylcyanohydrins. p. 9 S13. Enantiomeric excess (ee) determination of compounds 3a – 3f prepared by the three-step cascade flow process. p. 15 S14. Spectroscopic characterization of compound 3a – 3f. p. 16 S15 References.
A data management system for demand forecasting (1989)

In the United Kingdom the water industry has now largely abandoned the extrapolation of trends in measured water consumption as a means of forecasting future water demands in favour of the component method. This method involves the division of the total demand into three parts: unmeasured, measured and unaccounted‐for water. The modelling of these three components imposes a major data requirement, particularly when forecasts are to be produced on a routine basis for a large number of small areal units. Both data handling and modelling have been greatly facilitated by the creation of a data management system based upon two readily available commercial software packages mounted on a microcomputer.
Chlamydia trachomatis-Induced Salpingitis in Mice (1983)

Inoculation of the mouse pneumonitis biovar of Chlamydia trachomatis into the ovarian bursa of mice resulted in salpingitis. An acute inflammatory response in the bursa and contiguous oviduct peaked at six to nine days postinoculation. At day 14, most animals showed an acute and chronic infiltrate that occluded the oviductal lumen in some sections. Inflammatory exudate and debris accumulated in the periovarial space near the ostium of the oviduct. Inclusions were demonstrated in the lumenal epithelial cells of the oviduct and uterus. The mouse pneumonitis agent could be recovered from genital tissues for up to 21 days postinoculation but not from other organs. IgG antibodies to the mouse pneumonitis agent were detected at seven days postinoculation and reached peak titers by 21-30 days. By 25-30 days postinoculation, the inflammatory reaction declined and hydrosalpinx was observed. This model for salpingitis may be useful in understanding some aspects of the pathogenesis of C trachomatis genital infections.
Flexible Depth of Field Photography (2010)

The range of scene depths that appear focused in an image is known as the depth of field (DOF). Conventional cameras are limited by a fundamental trade-off between depth of field and signal-to-noise ratio (SNR). For a dark scene, the aperture of the lens must be opened up to maintain SNR, which causes the DOF to reduce. Also, today's cameras have DOFs that correspond to a single slab that is perpendicular to the optical axis. In this paper, we present an imaging system that enables one to control the DOF in new and powerful ways. Our approach is to vary the position and/or orientation of the image detector during the integration time of a single photograph. Even when the detector motion is very small (tens of microns), a large range of scene depths (several meters) is captured, both in and out of focus. Our prototype camera uses a micro-actuator to translate the detector along the optical axis during image integration. Using this device, we demonstrate four applications of flexible DOF. First, we describe extended DOF where a large depth range is captured with a very wide aperture (low noise) but with nearly depth-independent defocus blur. Deconvolving a captured image with a single blur kernel gives an image with extended DOF and high SNR. Next, we show the capture of images with discontinuous DOFs. For instance, near and far objects can be imaged with sharpness, while objects in between are severely blurred. Third, we show that our camera can capture images with tilted DOFs (Scheimpflug imaging) without tilting the image detector. Finally, we demonstrate how our camera can be used to realize nonplanar DOFs. We believe flexible DOF imaging can open a new creative dimension in photography and lead to new capabilities in scientific imaging, vision, and graphics.
Antitumor activity of sequential treatment with tyrosine kinase inhibitors (TKI) after failure of RAD001 in metastatic renal cell carcinoma (mRCC). (2010)

e15132 Background: There are only limited data for the outcome of mRCC patients after failure of both TKI and RAD001 treatment. We retrospectively analysed patients who received subsequent treatment after failure of RAD001. Methods: 39 patients who failed at least one TKI and RAD001 were identified and retrospectively studied at our institution. 15 patients received additional therapy, of whom 14 were evaluable for response. Subsequent treatment consisted of: sunitinib (N=5), sorafenib (N=7), both TKI sequentially (N=2), bevacizumab/IFN (N=1), and an investigational agent (N=1). At start of post-RAD001 therapy 6 patients (40%) had high risk, 7 patients (47%) had intermediate and 2 patients (13%) low risk according to MSKCC. Overall survival (OS) was calculated from the initiation of first TKI therapy. Results: Median progression-free survival (PFS) of first-line TKI was 10.7 and 5.8 months in patients with and without post-RAD001 treatment, respectively. However, PFS of RAD001 was similar in both groups (4.7 and 5 months). Subsequent systemic treatment after RAD001 was associated with a PFS of 5.1 months. Best response consisted of 64% SD (N=9), 21% PR (N=3), and 14% PD (N=2). Six patients (40%) were re-exposed to a previously given TKI, and 9 patients (60%) received a different systemic treatment. Eight patients are still on treatment, while 2 patients switched to best supportive care. The median OS for patients with and without post-RAD001 treatment is 28.2 and 21.2 months (P=0.08), respectively. Conclusions: Subsequent treatment after failure of TKI and RAD001 is associated with a promising PFS of 5.1 months and disease control in the majority of patients (86%). However, subsequent therapy was given to patients who achieved superior PFS response to initial TKI exposure, which may indicate an important factor for patient selection for subsequent therapy after failure of TKI and RAD001 in the clinic. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis, Pfizer, Roche Bayer, Novartis, Pfizer, Roche Wyeth Novartis, Pfizer
Biaxial orientation of linear polyethylenes using the compressive deformation process (1997)

Abstract The tensile properties of three grades of linear polyethylene were enhanced by a factor of as much as 15 using a melt/solid phase compressive deformation process that produced equi‐biaxial planar orientation in the sheet. Ultra high molecular weight polyethylene with planar isotropy and an in‐plane modulus of 10 GPa and a tensile strength of 330 MPa was produced using this method. It was found that the molecular weight had a significant influence on the optimum processing temperature, the ultimate biaxial deformation ratio and hence the ultimate tensile properties. High density polyethylene processed under ideal conditions had a tensile modulus of 2.3 GPa and a tensile strength of 250 MPa. The tensile strength increased linearly with increasing biaxial deformation ratio and the tensile modulus increased non‐linearly with increasing biaxial deformation ratio. The deformation rate and the dwell time did not have a significant effect on the tensile properties. Shrinkage tests showed that biaxial deformation was less effective than uniaxial deformation in inducing orientation of the polymer chains, however differential scanning calorimetry results were consistent with the presence of extended chain crystals in very highly oriented ultra high molecular weight polyethylene sheets.
An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH3 Encodes for HLA-A0201-Restricted CD8+ Cytotoxic T Cell Epitopes (2011)

We identified two novel HLA-A0201-restricted cytotoxic T cell epitopes derived from a (-1) frameshift mutation of a coding A(8) tract within the MSH3 gene. These were (386)-FLLALWECSL (FSP18) and (387)-LLALWECSL (FSP19) as well as (403)-IVSRTLLLV (FSP23) and (402)-LIVSRTLLLV (FSP31), respectively. These results suggest that MSH3(-1) represents another promising MSI(+)-induced target antigen. By identifying two distinct epitopes within MSH3(-1), the sustained immunogenicity of the frameshift mutated sequence was confirmed. Our data therefore encourage further exploitation of MSH3 as a piece for peptide-based vaccines either for therapeutic or--even more important--preventive purposes.
Foveal Translocation: A Comparison of two Techniques (1998)

Subfoveal choroidal neovascular membrane is a leading cause of legal blindness. Photocoagulation has been effective, but photocoagulation of the fovea causes a decrease in vision immediately after treatment. Surgical removal of the choroidal neovascular membrane is effective for choroidal neovascular membrane in some cases, but it restores useful vision for reading (20/40 or better) in a small number of cases of choroidal neovascular membrane not due to presumed ocular histoplasmosis syndrome. A new treatment for subfoveal choroidal neovascular membrane, foveal translocation, is an innovative procedure in which the fovea is translocated onto healthier retinal pigment epithelium. Three techniques have been developed to relocate the retina, 2 of which (retinotomy and scleral shortening) we performed in 5 cases each. Preliminary results in these 10 cases indicate that foveal translocation provides improvement of visual acuity in 40% of eyes and final visual acuities useful for reading (better than 20/40) in 20% of eyes undergoing translocation with either technique. Further study is essential to refine the amount of translocation needed and to decrease complications of the 2 techniques, including retinal detachment, proliferative vitreoretinopathy, macular pucker, corneal astigmatism, and constricted visual field.
Single-shot high aspect ratio bulk nanostructuring of fused silica using chirp-controlled ultrafast laser Bessel beams (2014)

We report single-shot, high aspect ratio nanovoid fabrication in bulk fused silica using zeroth order chirp-controlled ultrafast laser Bessel beams. We identify a unique laser pulse length and energy dependence of the physical characteristics of machined structures over which nanovoids of diameter in the range 200–400 nm and aspect ratios exceeding 1000 can be fabricated. A mechanism based on the axial energy deposition of nonlinear ultrashort Bessel beams and subsequent material densification or rarefaction in fused silica is proposed, intricating the non-diffractive nature with the diffusing character of laser-generated free carriers. Fluid flow through nanochannel is also demonstrated.
Quality of Life in Swedish Children with Eczema (2007)

The burdens of childhood eczema are many and some can be assessed with quality of life (QoL) questionnaires. Seventy-eight Swedish children with mild-to-severe eczema ("atopic dermatitis", prurigo Besnier), fulfilling established diagnostic criteria, were investigated for the effect of eczema on QoL. This was measured with validated questionnaires: the Infants' Dermatitis Quality of Life Index (IDQOL), the Children's Dermatology Life Quality Index (CDLQI), and the Dermatitis Family Impact Questionnaire (DFI). The study also included scoring of eczema severity. The median score was 7.0 (range 1-18) for IDQOL, 6.0 (range 2-18) for the CDLQI, and 8.0 (range 0-27) for DFI. There was no significant difference in scores between boys and girls. The DFI scores were higher for younger than for older children, and also higher for those with both eczema and asthma, food allergy/intolerance, allergic rhinoconjunctivitis or urticaria. The QoL scores correlated significantly with the Rajka & Langeland score, but not with objective SCORAD. The outcome of the QoL instruments in this study clearly demonstrates that childhood eczema affects the children's and their families' QoL. QoL data offers a patient-oriented outcome measure of importance for understanding the patients' and their families' situation. Such information can also be used in intervention studies and in the allocation of healthcare resources to eczema care.
Open Editorial Office (1978)

<h3>To the Editor.—</h3> I have just finished reading your excellent editorial in the MarchArchives(114:361, 1978) and thought I should drop you a few lines to express my thoughts about the "open editorial policy." As an author, I must confess that I have been very positively impressed by the fairness you have consistently shown as an editor. I find it a stimulating experience to deal with a conscientious editor who shows concern as to the negative repercussions that an unwarranted rejection of a manuscript could have. From my own experience and that of several of my colleagues, unfortunately, this does not appear to be the prevalent editoral attitudes in other journals. Perhaps, that is the reason why very few authors bother to request reconsideration of their manuscript. I believe you have taken a major step in the right direction by addressing yourself to the problem of the open editorial
Wear of diamond and diamondlike carbon films. (2002)

Detailed tribological studies on diamond and diamond-like carbon (DLC) films have confirmed that these films are inherently self-lubricating and resistant to abrasive, adhesive and corrosive wear. Because of their high chemical inertness, they are also resistant to corrosion and oxidation (even at elevated temperatures). The combination of such exceptional qualities in these films makes them ideal for a wide range of demanding tribological applications (such as microelectromechanical systems, cutting tools, mechanical seals, magnetic hard disks, etc.). These films, available for more than three decades, have been used extensively for tooling and magnetic hard disk applications. Their potential in other application areas is currently being explored around the world. With the development of new and more robust deposition methods in recent years, it is envisioned that the production of high quality diamond and DLC films will become very cost effective and highly reliable for large-scale applications in the transportation and manufacturing sectors. In this paper, sliding wear mechanisms of diamond and DLC films will be presented. Specifically, it will be shown that, in general the wear of these films is extremely low (mainly because of their exceptional hardness and low friction characteristics). Specific test conditions established during each sliding test, however,more » may dramatically affect the wear performance of certain diamond and DLC films. One of the dominant wear mechanismsrelates to a phase transformation that is primarily the result of very high mechanical and thermal loadings of sliding contact interfaces. The transformation products (such as disordered graphite) trapped at the sliding interface may transfer to themating surface and significantly affect friction and wear. This paper describes, in terms of structural and fundamental tribological knowledge, the ideal film microstructures and chemistry, as well as operational conditions under which diamond and DLC films perform the best and provide superlow friction and wear properties in sliding tribological applications.« less
Basolateral membrane sodium-independent Cl-/HCO3- exchanger in rat inner medullary collecting duct cell. (1990)

Previous studies have shown that the middle third of the rat inner medullary collecting duct (IMCD-2) secretes protons despite the absence of intercalated cells, the cell thought to secrete protons in other portions of the collecting duct. A new cell, the IMCD cell, is the predominant cell in IMCD-2. The mechanism responsible for base exit in the IMCD cell was characterized by measuring cell pH of isolated perfused tubules with 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein. Reduction of bath HCO3- caused a significant and reversible decrease in cell pH, whereas a similar change in luminal HCO3- had a significantly smaller effect, indicating that the HCO3-/H+ permeability of the basolateral membrane is much larger than the apical membrane. The rate of cell acidification induced by reduction in bath HCO3-, a measure of basolateral HCO3- transport, was significantly decreased in the absence of bath and lumen Cl. Decreases in bath Cl caused a significant and reversible increase in cell pH, which was not changed significantly by complete removal of Na from perfusate and bath, but was significantly inhibited by basolateral 4',5'-diisothiocyanostilbene-2,2'-disulfonic acid. A chemical voltage clamp did not inhibit the rate of cell alkalinization after bath Cl removal, indicating that Cl-/HCO3- exchange is not via parallel Cl and HCO3- conductances. Cell pH was measured in single cells by low-light-level imaging to show that most cells contain the chloride-dependent HCO3- pathway. We conclude that the rat IMCD cell possesses a basolateral Na-independent CL-/HCO3- exchanger which may serve as the base exit step for transepithelial proton secretion.
Commensal Bacterial Endocytosis in Epithelial Cells Is Dependent on Myosin Light Chain Kinase–Activated Brush Border Fanning by Interferon-γ (2014)

Abnormal bacterial adherence and internalization in enterocytes have been documented in Crohn disease, celiac disease, surgical stress, and intestinal obstruction and are associated with low-level interferon (IFN)-γ production. How commensals gain access to epithelial soma through densely packed microvilli rooted on the terminal web (TW) remains unclear. We investigated molecular and ultrastructural mechanisms of bacterial endocytosis, focusing on regulatory roles of IFN-γ and myosin light chain kinase (MLCK) in TW myosin phosphorylation and brush border fanning. Mouse intestines were sham operated on or obstructed for 6 hours by loop ligation with intraluminally administered ML-7 (a MLCK inhibitor) or Y27632 (a Rho-associated kinase inhibitor). After intestinal obstruction, epithelial endocytosis and extraintestinal translocation of bacteria were observed in the absence of tight junctional damage. Enhanced TW myosin light chain phosphorylation, arc formation, and brush border fanning coincided with intermicrovillous bacterial penetration, which were inhibited by ML-7 and neutralizing anti-IFN-γ but not Y27632. The phenomena were not seen in mice genetically deficient for long MLCK-210 or IFN-γ. Stimulation of human Caco-2BBe cells with IFN-γ caused MLCK-dependent TW arc formation and brush border fanning, which preceded caveolin-mediated bacterial internalization through cholesterol-rich lipid rafts. In conclusion, epithelial MLCK-activated brush border fanning by IFN-γ promotes adherence and internalization of normally noninvasive enteric bacteria. Transcytotic commensal penetration may contribute to initiation or relapse of chronic inflammation.
Two new Veratrum alkaloids, hosukinidine and epirubijervine from illuminated Veratrum plant. (1979)

Hosukinidine, (20R, 22R, 25S)-veratra-5, 12-dien-3β-ol, and epirubijervine, (22R, 25S)-solanid-5-ene-3β, 12β-diol, were isolated from illuminated Veratrum plant.
Template synthesis of methylammonium lead iodide in the matrix of anodic titanium dioxide via the direct conversion of electrodeposited elemental lead (2018)

A new processing technique is proposed for composites based on the hybrid organic inorganic perovskite MeNH3PbI3 and anodic titania nanotube arrays, which includes a direct gas phase conversion of metal lead nanorods electrodeposited inside the pores of anodic titanium dioxide. This technique may be useful for a design of solar cells and optoelectronics applications.
ChemInform Abstract: Inhibition of Topoisomerase I by Naphthoquinone Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Optical-Fiber-Based Airborne Particle Sensor (2017)

A new optical-fiber-based airborne particle counter is reported. Unlike traditional light-scatter-based techniques, the particle is detected through the drop in optical fiber coupling efficiency as the particle disrupts the electromagnetic mode of the optical beam. The system is simple, substantially smaller than traditional systems, and does not require high power laser input. This makes it attractive for wearable air quality monitors where size is a premium. There is close agreement between theoretical model and experimental results for solid and liquid particles in the 1 to 10 µm range.
Characterisation of a Three-Dimensional (3D) Cell Culture Model of Adrenocortical Carcinoma (2023)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)