gebhart/patrepeval huggingface dataset:
Spoken Dialog System for Next Generation Knowledge Access (2008)

This paper described our development dialog system on Kyoto tourist information assistance. Dialog part of our system helped user to make an appropriate query. Information analysis part would be assisted for user to select the retrieved information. Nowadays we can get most information through the Internet. However, we have a trouble to pick up expected information from the huge results with conventional search engines. Especially in mobile terminal, we are confronted with great difficulties for two factors. One is that most of users cannot make an appropriate query because their request is vague with theirselves. The other is that the retrieved information has huge variation and mobile terminal has small area for displaying them. Therefore, we aim to develop technologies for the users to input their requests by familiar way and clarify what they want to know with displaying the retrieved information with suitable method.
A model for technology assessment as applied to closed loop infusion systems (1995)

Closed loop infusion systems may have a role in critical care practice. However, for most applications, further development is required to move this technology from the innovation phase to the point where it can be evaluated so that its role in critical car practice can be defined. Each application of closed loop infusion systems must be independently validated by appropriately designed research studies. Users should be provided with the clinical parameters driving each closed loop system so that they can ensure that it agrees with their opinion of acceptable medical practice. Clinical researchers and leaders in industry should collaborate to perform the scientifically valid, outcome-based research that is necessary to evaluate the effect of this new technology. The original model we developed for technology assessment required the addition of several more questions to produce a complete analysis of an emerging technology. An emerging technology should be systematically assessed (using a model such as the model developed by the Society of Critical Care Medicine), before its introduction into clinical practice in order to provide a focus for human outcome validation trials and to minimize the possibility of widespread use of an unproven technology.
Trap design for insertable second‐nuclei radiofrequency coils for magnetic resonance imaging and spectroscopy (2009)

Abstract The application of nuclear magnetic resonance spectroscopy in metabolic studies usually includes concurrent operation at two different frequencies to enable excitation and detection of two different nuclei. When using separate radiofrequency coils for the multinuclear excitation, coupling between the two coils has been shown to be a problem, resulting in resonance frequency shifting and reduced sensitivity of the 1 H coil. Among the methods to reduce this coupling is the placement of an 1 H trap on the second‐nuclei coil. This article presents the benefits of this method, specifically in this case for 31 P imaging/spectroscopy, through modeling results, bench measurements, imaging, and spectra acquisition. The use of a resonant trap in conjunction with a modular design permitted the insertion of the phosphorus coil as an “add‐on” into multiple existing proton coils, suggesting particular applicability in the high‐field arena, where spectroscopy holds great promise, but where proton coil design complexity exists that is not easily re‐engineered for dual‐nuclei use. © 2009 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 35B: 121–132, 2009
Occluded human recognition for a leader following system using 3D range and image data in forest environment (2014)

This paper describes the occluded target recognition and tracking method for a leader-following system by fusing 3D range and image data acquired from 3D light detection and ranging (LIDAR) and a color camera installed on an autonomous vehicle in forest environment. During 3D data processing, the distance-based clustering method has an instinctive problem in close encounters. In the tracking phase, we divide an object tracking process into three phases based on occlusion scenario; before an occlusion (BO) phase, a partially or fully occlusion phase and after an occlusion (AO) phase. To improve the data association performance, we use camera's rich information to find correspondence among objects during above mentioned three phases of occlusion. In this paper, we solve a correspondence problem using the color features of human objects with the sum of squared distance (SSD) and the normalized cross correlation (NCC). The features are integrated with derived windows from Harris corner. The experimental results for a leader following on an autonomous vehicle are shown with LIDAR and camera for improving a data association problem in a multiple object tracking system.
Ionosphere Research of the National Bureau of Standards during 1939 (1940)

The program of regular measurements of critical frequencies and virtual heights of the layers of the ionosphere continued throughout the year for frequencies from 600 kc/sec to those above the F 2 critical frequency (maximum, 13,000 kc/sec). Regular publication of these data maintained unbroken the continuity of the National Bureau of Standards' published ionosphere data since 1933. This continuity is important in studying the regular and irregular characteristics of the ionosphere, diurnally, seasonally, and year to year with the sunspot‐cycle. The ionization‐densities of all the layers of the ionosphere continued to decrease with the waning sunspot‐activity. The vertical‐incidence ionosphere‐measurements were supplemented by oblique‐incidence radio field‐intensity records of stations on frequencies from 550 to 30,000 kc/sec. The oblique‐incidence records gave additional information on maximum usable frequencies, absorption, ionosphere storms, sudden ionosphere disturbances, and sporadic E‐layer. They also gave information on the condition of the ionosphere at considerable distances from Washington.
Characterization of the Syringomycin Synthetase Gene Cluster (1998)

With this work we have completed the characterization of the syringomycin synthetase gene cluster. In particular, by sequencing additional 28.5 kilobase pairs we show that the nine modules involved in the binding of the nine amino acids of syringomycin are localized on SyrB and SyrE, with SyrE carrying eight modules. The recombinant SyrB and the first and second modules of SyrE (SyrE1 and SyrE2) have been expressed in Escherichia coli and purified. The biochemical data indicate that SyrB binds threonine, the putative precursor of the last amino acid of syringomycin, whereas SyrE1 and SyrE2 bind serine, the first and the second amino acids of syringomycin, respectively. On the basis of the sequence analysis and the biochemical data presented here, it appears that syringomycin synthetase is unique among peptide synthetases in that its genetic organization does not respect the "colinearity rule" according to which the order of the amino acid binding modules along the chromosome parallels the order of the amino acids on the peptide. This feature, together with the absence of a single transcription unit and the absence of epimerase-like domains make syringomycin synthetase more related to the eukaryotic peptide synthetases than to the bacterial counterparts.
Paclitaxel poliglumex (PPX) in combination with carboplatin (carb) for the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC): Preliminary data (2005)

7230 Background: PPX (XYOTAX), a macromolecular drug conjugate that links paclitaxel with biodegradable polymer, poly-L-glutamic acid, is water soluble and can be administered as a 10 minute infusion. Eliminating the need for CremophorEL reduces the risk of hypersensitivity reactions, even without premedication. Preclinical and clinical findings show that PPX is relatively stable in plasma; more than 95% of paclitaxel in circulation is present as the inactive conjugate, reducing systemic exposure to high concentrations of free paclitaxel. The antitumor activity of single agent PPX in chemotherapy naïve high-risk patients with NSCLC has been previously reported. In addition, PPX has been successfully combined with standard doses of cisplatin and carb. This multicenter, open label study evaluates the safety and efficacy of PPX in a standard doublet regimen for 1st line treatment of NSCLC. Methods: PPX (210 mg/m2) was administered as a short (10–20 minute) IV infusion followed carb (AUC 6) q3w to chemotherapy-naïve patients (pts) with performance status (PS) 0–2. Pts were treated for up to 6 cycles. Safety was assessed using NCI CTC (v 2). Efficacy assessments were done after every 2nd cycle using RECIST. Plasma samples were collected for pharmacokinetic (PK) assessment of PPX. Results: 74 pts were treated. The median age was 64 (range 32–85). 53% of pts were male. 14% of pts had PS2. Of the 60 pts with efficacy assessment following cycle 2, 9 pts (15%) had partial response and 24 pts (40%) had stable disease as the best response. Adverse event (AE) data are available for 40 pts (see table). No hypersensitivity reactions were observed. Detailed PK data will be presented. Conclusions: Preliminary data suggest that PPX (210 mg/m2) in combination with carb (AUC 6) is active as 1st line treatment for NSCLC. PPX demonstrates easily manageable toxicities and is generally well tolerated. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Cell Therapeutics Cell Therapeutics Cell Therapeutics
An SNMP agent for active in-network measurements (2012)

Active network measurements play an important role not only in network monitoring for OAM purposes, but also in assessing the current network status and providing real-time information for the optimization of applications. This paper proposes the extension of SNMP-based monitoring mechanisms to also support active in-network measurements conforming to the standardized OWAMP protocol. A specialized SNMP agent is designed and implemented, featuring an OWAMP-compliant probe module and accompanied by the appropriate MIB. The proper operation of the mechanism is validated in a laboratory testbed under emulated network conditions, achieving remarkable accuracy and seamless integration with SNMP-compatible network managers.
Experimental study using coir geotextiles in watershed management (2005)

Abstract. This paper presents the results of a field experiment conducted in Kerala, South India, to test the effectiveness of coir geotextiles for embankment protection. In the context of sustainable watershed management, coir is a cheap and locally available material that can be used to strengthen traditional earthen bunds or protect the banks of village ponds from erosion. Particularly in developing countries, where coir is abundantly available and textiles can be produced by small-scale industry, this is an attractive alternative for conventional methods.
LKM-1 Sera from Autoimmune Hepatitis Patients that Recognize ERp57, Carboxylesterase 1 and CYP2D6 (2010)

Liver kidney microsomal antibody type 1 (LKM-1) is a diagnostic marker for autoimmune hepatitis type 2 (AIH-2). Characterization of LKM autoantibodies of patients with AIH-2 demonstrated that a proportion of LKM sera contains autoantibodies which recognize one or more small linear epitopes on cytochrome P450, CYP2D6, an enzyme of drug metabolism pathways. The identification and epitope mapping of antigens involved in autoimmune diseases are important in understanding the mechanisms triggering autoimmunity and providing guidance for designing immunomodulatory therapy. In this study, several proteins recognized by LKM-1-positive sera in rat and human hepatic microsomes were analyzed by MALDI-TOF-MS after separation with ion-exchange chromatography or two-dimensional polyacrylamide gel electrophoresis. We identified these proteins as ERp57 and carboxylesterase 1 (CES1) as well as CYP2D6. Epitopes in ERp57 and CES1 recognized by LKM-1-positive serum were investigated by enzyme-linked immunosorbent assay (ELISA) with protease-digested peptides of ERp57 and CES1. The peptides comprising amino acids 105-129 of ERp57 and 558-566 of CES1 were specifically recognized by the serum. The epitopes in EPp57 and CES1 recognized by LKM-1-positive sera were homologous with those in hepatitis C virus (HCV). Viral infection of such as HCV may thus possibly trigger autoimmune hepatitis.
Identification of Patients at High Risk of Noncompliance in Substance Dependence Treatment (2007)

Noncompliance in substance dependence treatment seriously threatens its effectiveness. Pretreatment identification of those at the highest risk allows targeting of specific compliance enhancing interventions to those who may benefit most from it. In a cohort of 292 patients entering a 30-day treatment program for substance abuse treatment, several potential predictors of noncompliance were recorded before treatment. Compliance was registered when treatment was discontinued before the 30th day. Logistic regression was used to identify independent predictors of noncompliance and the area under the receiver-operating characteristic (ROC) curve was quantified to assess their joint predictive value. Mean age was 35 years, 80% were male. During follow-up 31% became noncompliant. Independent predictors of noncompliance were male gender, less than 10 years of education, severity of medical and drug problems, and behavioral intention to comply with treatment. The area under the ROC curve was 0.70 (95% CI: 0.64-0.76). In conclusion, noncompliance in a substance abuse treatment program can be predicted using five easy to assess patient characteristics. These results may be useful in preventing noncompliant behavior early in treatment by motivational counseling strategies.
Supplementary Data: list of figures and tables from <i>(R)</i>-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in <i>IDH</i>-Mutant Cancers (2023)

&lt;p&gt;List of supplementary figures and tables.&lt;/p&gt;
Endothelial study of iris-claw phakic lens: Four year follow-up (1998)

Although there was a slight progressive cell loss after IOL implantation, the morphometric changes recovered and were close to the preoperative levels. This suggests that endothelial damage occurred primarily during the surgical procedure.
Polar codes for discrete alphabets (2012)

An open problem in polarization theory is whether all memoryless channels and sources with composite (that is, non-prime) alphabet sizes can be polarized with deterministic, Arıkan-like methods. This paper answers the question in the affirmative by giving a method to polarize all discrete memoryless channels and sources. The method yields codes that retain the low encoding and decoding complexity of binary polar codes.
Current gain collapse in HBTs analysed by transient interferometric mapping method (2007)

Thermal distribution during a current gain collapse event is investigated in multi-finger InGaP/GaAs HBTs using the transient interferometric mapping method. The onset of the collapse is observed at time of about 1ms in devices with a low emitter ballasting resistance R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</sub> , while for HBTs with a high R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</sub> , the current is distributed equally over the fingers. 3D thermal simulation supports the results and allows an estimation of temperature at which the collapse occurs.
J.S. Bach y el compás de 2/4 (1996)

Es una traducción de: Two case studies in performance practice and the details of notation. 1: J. S. Bach and 2/4 time, en Early Music, Vol. XXI núm. 4 (Noviembre 1993, pp. 613 -22).
A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues (2004)

A new [2 + 2 + 2] approach to construct GPI molecules through the efficient synthesis of glucosamine-inositol and tetramannose intermediates led to a total synthesis of a GPI-anchor of Trypanosoma cruzi, and also afforded a key intermediate for the synthesis of valuable [4-deoxy-Man-III]-GPI analogues.
The development of B-stimulant drugs in the treatment of heart failure (1988)

El V Congreso Internacional de la Sociedad Española de Química Terapéutica. 1er Congreso Hispano-Portugués de Química Terapéutica tuvo lugar en el Auditorio de la Universidad de Santiago de Compostela los días 23, 24 y 25 de septiembre de 1987. En el Congreso se dictaron nueve Conferencias Plenarias y se presentaron 130 Comunicaciones, la mayor parte de las cuales referentes a los tres grandes temas que ha abordado el Congreso: Productos naturales de interés en Química Terapéutica, Agentes Cardiovasculares y Agentes Quimioterápicos (antiparasitarios, antivirales, antineoplásicos y antibióticos). Este libro contiene el texto íntegro de las Conferencias Plenarias que allí se dictaron.
Synthesis and Integration of Hybrid Metal Nanoparticles Covered with a Molecularly Imprinted Polymer Nanolayer by Photopolymerization (2023)

Interfacing recognition materials with transducers has consistently presented a challenge in the development of sensitive and specific chemical sensors. In this context, a method based on near-field photopolymerization is proposed to functionalize gold nanoparticles, which are prepared by a very simple process. This method allows in situ preparation of a molecularly imprinted polymer for sensing by surface-enhanced Raman scattering (SERS). In a few seconds, a functional nanoscale layer is deposited by photopolymerization on the nanoparticles. In this study, the dye Rhodamine 6G was chosen as a model target molecule to demonstrate the principle of the method. The detection limit is 500 pM. Due to the nanometric thickness, the response is fast, and the substrates are robust, allowing regeneration and reuse with the same performance level. Finally, this method of manufacturing has been shown to be compatible with integration processes, allowing the future development of sensors integrated in microfluidic circuits and on optical fibers.
Finding Semantic Associations on Express Lane (2004)

We introduce a new codification scheme for efficient computation of measures in semantic networks. The scheme is particularly useful for fast computation of semantic associations between words and implementation of an informational retrieval operator for efficient search in semantic spaces. Other applications may also be possible. 1.
Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. [Erratum to document cited in CA116(5):41380f] (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antibacterial activity of new tetracyclic quinolone antibacterials. [Erratum to document cited in CA116(5):41380f]Masahiro Taguchi, Hirosato Kondo, Yoshimasa Inoue, Yoshihiro Kawahata, Yoshikau Jinbo, Fumio Sakamoto, and Goro TsukamotoCite this: J. Med. Chem. 1992, 35, 25, 4767Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jm00103a019https://doi.org/10.1021/jm00103a019research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermomechanical Modeling and Testing of Scan Weldments (1995)

This article presents a thermomechanical analysis of the new scan welding method, which has been recently developed to achieve simultaneous control of multiple weld quality features. Unlike conventional welding with a concentrated heat source in sequential motion, the scan welding torch reciprocates rapidly on dynamic trajectories, and its power is modulated so as to provide a regulated heat input distribution on the entire weld surface. The new process was modeled by a real-time analytical, lumped model, consisting of a composite heat source,, double-cell circulation in the weld puddle, dynamic solid conduction and estimation of the mechanical strength of the joint. The process is computationally and experimentally shown to generate a smooth, uniform temperature field, and to deposit the full length of the weld bead simultaneously at a controlled solidification rate. The observed interlacing of grains on the bead interface and the regulated material microstructure yield improved tensile joint strength. The model can be used for design of a closed-loop thermal controller, using temperature feedback from an infrared pyrometer and model-referenced parameter identification.
Macrophage Secretory Phospholipase A2 Group X Enhances Anti-inflammatory Responses, Promotes Lipid Accumulation, and Contributes to Aberrant Lung Pathology (2008)

Secreted phospholipase A2 group X (sPLA(2)-X) is one of the most potent enzymes of the phospholipase A(2) lipolytic enzyme superfamily. Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis. We studied the role of sPLA(2)-X enzyme activity in vitro and in vivo, by generating sPLA(2)-X-overexpressing macrophages and transgenic macrophage-specific sPLA(2)-X mice. Our results show that sPLA(2)-X expression inhibits macrophage activation and inflammatory responses upon stimulation, characterized by reduced cell adhesion and nitric oxide production, a decrease in tumor necrosis factor (TNF), and an increase in interleukin (IL)-10. These effects were mediated by an increase in IL-6, and enhanced production of prostaglandin E(2) (PGE(2)) and 15-deoxy-Delta12,14-prostaglandin J(2) (PGJ(2)). Moreover, we found that overexpression of active sPLA(2)-X in macrophages strongly increases foam cell formation upon incubation with native LDL but also oxidized LDL (oxLDL), which is mediated by enhanced expression of scavenger receptor CD36. Transgenic sPLA(2)-X mice died neonatally because of severe lung pathology characterized by interstitial pneumonia with massive granulocyte and surfactant-laden macrophage infiltration. We conclude that overexpression of the active sPLA(2)-X enzyme results in enhanced foam cell formation but reduced activation and inflammatory responses in macrophages in vitro. Interestingly, enhanced sPLA(2)-X activity in macrophages in vivo leads to fatal pulmonary defects, suggesting a crucial role for sPLA(2)-X in inflammatory lung disease.