gebhart/patrepeval huggingface dataset:
Use of a Molasses-based Liquid Feed Sup- plement to Deliver Ivermectin to Cattle to Control Ectoparasites* (2012)

KEY WORDS: Feed supplement, free-choice molasses, Rhipicephalus (Boophilus) microplus, Rhipicephalus (Boophilus) annulatus, tick controlABSTRACTTwo different dosages of ivermectin (25 ppm and 100ppm) were used to medicate a liquid molasses feed supplement for free-choice consumption by cattle. Calves that fed on supplement medicated at 25 ppm with ivermectin had a 14 day mean consumption of 0.62 ± 0.07 kg supplement/animal/day producing an average dose of 15.5 mg of ivermectin per calf. The mean ivermectin level in serum for the 25 ppm rate was 15.7 ± 2.6 ppb for days 8 - 14 of the study, and the peak average ivermectin blood serum level was 20 ± 8.8 ppb on the fifteenth day, one day after the last day of treatment. Calves that fed on supplement medicated at 100 ppm ivermectin had a 14 day mean consumption of 0.63 ± 0.14 kg supplement/animal/day, producing an average daily dose of 63 mg of ivermectin per calf. The peak average ivermectin blood serum level for the 100 ppm rate was 85.6 ± 23.6 ppb on the tenth day of treatment; and for days 8 - 14 of the trial the mean ivermectin blood serum level was 76.7 ± 6.2 ppb. Seven days after termination of the study, no ivermectin was detected in the serum of cattle treated at the 25 ppm rate, while cattle treated at the 100 ppm rate still had ivermectin detectable at ~ 14 ppb. Fourteen days after termination of treatment, no ivermectin was detected in the serum of cattle treated at the 100 ppm rate. An ivermectin blood serum level of ≥ 10 ppb is known to control biting flies and ticks
Parallel dual-color fluorescence cross-correlation spectroscopy using diffractive optical elements (2005)

Dual-color cross-correlation spectroscopy allows the detection and quantification of labeled biomolecules at ultra-low concentrations, whereby the sensitivity of the assay correlates with the measurement time. We now describe a parallel multifocal dual-color spectroscopic configuration employing multiple avalanche photodiodes and hardware correlators. Cross-correlation curves are obtained from several dual-color excitation foci simultaneously. Multifocal dual-color excitation is achieved by splitting each of two laser beams (488 and 633 nm) into four sub-beams with the help of two 2x2 fan-out diffractive optical elements (DOEs), and subsequent superposition of the two sets of four foci. The fluorescence emission from double-labeled biomolecules is detected by two 2x2 fiber arrays.
Encapsulation of Mesenchymal Stem Cells: Dissecting the Underlying Mechanism of Mesenchymal Stem Cell Transplantation Therapy (2020)

Mesenchymal stem cells (MSCs) are widely considered good candidates for cell transplantation therapy. Various central nervous system disorders have been suggested as suitable targets for MSC transplantation therapy. In this context, a great deal of basic and clinical research has been conducted to explore its clinical uses. Although depression is one of the most common diseases in the world, the response rate to the currently available treatment is insufficient and new treatments are much needed. Despite the fact that MSC transplantation therapy has the potential to elicit an antidepressant effect, few studies have been conducted on this topic to date and the underlying mechanism remains poorly understood. To address the development of a new treatment for depression, we evaluated the effect of MSCs using the encapsulation technique and Wistar-Kyoto rats. Encapsulation enables dissection of the complicated underlying mechanism of MSC transplantation therapy. Wistar-Kyoto rats that exhibit treatment-resistant depressive-like behaviors allow us to compare the effect of MSCs with that of conventional antidepressant treatment. In this commentary, we briefly summarize our recent published results and discuss future research prospects.
Studies on the Synthesis and Biological Activitiy of 6-Ethyl-4-aryl-5-methoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones (2011)

6-Ethyl-4-aryl-5-methoxycarbonyl-3,4-dihydropyrimidin-2(1H)-one derivatives (1-10) were synthesized by condensing urea with methyl 3-oxopentanoate and aromatic aldehydes in absol. ethanol using HCl as a catalyst according to the Biginelli reaction. The structures of the compounds were confirmed by spectroscopic and elemental analysis. The calcium channel blocker activities of the compounds were determined by the tests performed on isolated rat ileum and lamb carotid artery. On the isolated rat ileum, compound 2 was found to be more effective at 10(-5) mol/L concentration than nicardipine (CAS 55985-32-5). On the lamb carotid artery compounds 5, 6 and 4, 5, 6 were significantly active at 10(-6) mol/L and 10(-5) mol/L concentrations, respectively.
EVALUATION OF RECENT DATA FROM THE SANDIA NATIONAL LABORATORIES CLOSED BRAYTON CYCLE TESTING. (2018)

Abstract not provided.
Electronic beamsteering of active arrays with phase-locked loops (1994)

A new electronic beamsteering technique for active arrays is presented along with experimental results at 10 GHz. The technique uses a single balanced diode mixer to phase-lock neighboring oscillators in an active array. Each oscillator has its own antenna that radiates energy into free space, so the phase difference between oscillators determines the direction of the main radiating beam. An offset voltage added to the phase-locked loop controls the phase difference and beam direction. Experimental results demonstrate over 100/spl deg/ of adjustable phase difference between neighboring oscillators. Because of its simplicity, this technique has significant advantages over traditional beamsteering arrays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
P608 Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in Crohn's disease patients with endoscopic recurrence: follow-up data of a randomised, double-blind, double-dummy, 1-year, multicentre trial (2013)

postoperative complications, details on the anastomoses (technique, number and location), and the histology of the resected specimen. Complications were graded by severity (I-IV). Grade I: Minor complications, Grade II: Potentially lethal and require intervention, Grade III: Provides permanent impairment of organ function, Grade IV: Fatal complication. Patients were divided into four categories according to the preoperative medication. Results: 243 patients with CD were included, with a total of 351 admissions resulting in intra-abdominal surgery, and 155 complications, distributed in 101 (28.8%) procedures. Complications were: 14.2% grade I, 11.7% grade II, and 2.8% grade III. The mean postoperative hospital stay among patients suffering grade I, II and III complications, were 10.0, 16.7 and 39.4 days respectively, compared to patients without complications with a mean postoperative hospital stay of 7.6 days (p < 0.01). Twenty-five (7.2%) patients were reoperated. Smokers had more complications than non-smokers (37.4% vs. 25.5%, p = 0.03), and longer overall (17.0±1.5 vs. 13.8±0.7 days) and postoperative (11.7±1.1 vs. 9.1±0.5 days) stay in hospital than non-smokers (p = 0.05 and p = 0.04). Five patients had malignant histology in the resected specimen. There was no difference in the risk of complications according to different preoperative medication. There was no mortality.
Study on the Application of Dynamic Balanced Scorecard in the Service Industry (2008)

In order to solve the short-sighted problem in the service industry and help the enterprises of the service industry to carry though their performance management and strategic management effectively, considering the relativity between the balanced scorecard and the service-profit chain in the service industry, this paper introduces the balanced score card into the service industry. In view of the balanced scorecard's lack at dynamics in the practical implementations, system dynamics is used to build a dynamic balanced scorecard simulation model for the service industry. Simulate and observe the changing inner and outer environment in various phrases, analyze and compare the long term results and the short ones. Sequentially provide quantitative attestation for the decision of the enterprises. Support the enterprises' performance management and strategic management dynamically.
Follicular and luteal phase characteristics following early cessation of gonadotrophin-releasing hormone agonist during ovarian stimulation for in-vitro fertilization* (2000)

Gonadotrophin-releasing hormone agonists (GnRHa) are widely used in in-vitro fertilization (IVF) for the prevention of a premature rise in luteinizing hormone (LH) concentrations. However, the administration of GnRHa during the follicular phase may also impair subsequent luteal function due to retarded recovery of pituitary gonadotrophin secretion. Therefore, luteal supplementation is generally applied. The present study was designed to determine whether a premature LH surge would still be prevented after early cessation of GnRHa during ovarian stimulation and whether subsequent luteal phase LH production would be sufficient to support progesterone synthesis by the corpus luteum. Sixty patients were randomized for three groups: (i) A long GnRHa/human menopausal gonadotrophin (HMG) protocol with luteal support by repeated human chorionic gonadotrophin (HCG) (n = 20), (ii) early follicular phase cessation of GnRHa without luteal support (n = 20), and (iii) a long GnRHa protocol without luteal support (n = 20). Frequent ultrasound and blood sampling was performed during the entire IVF cycle. Forty normo-ovulatory women served as controls. No premature LH surges were found after early cessation of GnRHa. In this group, some pituitary recovery occurred during the late luteal phase, but this did not affect corpus luteum function. Progesterone concentrations were shown to be dependent on disappearance of the pre-ovulatory bolus of HCG. Pregnancies occurred in all three groups. In conclusion, early follicular phase cessation of GnRHa is still effective in the prevention of a premature rise in LH. Although some pituitary recovery was observed thereafter, corpus luteum function is still abnormal due to early luteolysis.
Race-Appreciation in Latin America (1918)

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Electronic Structure Investigations of Neutral and Charged Ruthenium Bis(β-diketonate) Complexes of Redox-Active Verdazyl Radicals (2011)

The electronic structures of (Vd)Ru(LX)(2) complexes (Vd = 1,5-diisopropyl-3-(2-pyridyl)-6-oxoverdazyl radical; LX = acac or hfac) as neutral, cationic, and anionic species have been investigated experimentally and computationally to probe the interplay between the ruthenium ion and the redox-active verdazyl ligand. The cationic complexes were prepared by oxidation of the corresponding neutral species with silver(I) salts. The hfac-based anionic complex was synthesized by reduction of the neutral species with cobaltocene, but the anionic acac analogue could not be prepared. Experimental (X-ray structures, electronic spectra) and computational (TD-DFT (PCM)) studies reveal that the expression of redox activity of the ligand and metal moieties is highly sensitive to the nature of the ancillary ligands on ruthenium. In the hfac series, the cationic, neutral, and anionic complexes can, respectively, be adequately described as Ru(II) complexes of a coordinated verdazyl cation, neutral radical, and anion. However, the more electron-donating acac coligands facilitate a stronger interaction between ruthenium and verdazyl via Ru(d) to Vd(π*) backbonding which is dependent on the overall charge of the complex and has the net effect of creating a high degree of metal-ligand covalency. Studies on the two cationic complexes reveal further distinctions between the acac- and hfac-containing systems: whereas the former has a significant open-shell singlet contribution to the complex ground state, this open-shell formulation is a minor component of the latter.
Protein Biosynthesis (1971)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Data from Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Response to toxicity in chemotherapies varies considerably from tissue to tissue and from patient to patient. An ability to monitor the tissue damage done by chemotherapy may have a profound impact on treatment and prognosis allowing for a proactive management in understanding and mitigating such events. For the first time, we investigated the feasibility of using whole-body imaging to map chemotherapeutic drug–induced toxicity on an individual basis.&lt;/p&gt;Experimental Design:&lt;p&gt;In a preclinical proof-of-concept, rats were treated with a single clinical dose of cyclophosphamide, methotrexate, or cisplatin. &lt;i&gt;In vivo&lt;/i&gt; whole-body imaging data were acquired using &lt;sup&gt;99m&lt;/sup&gt;Tc-duramycin, which identifies dead and dying cells as an unambiguous marker for tissue injury in susceptible organs. Imaging results were cross-validated using quantitative &lt;i&gt;ex vivo&lt;/i&gt; measurements and histopathology and compared with standard blood and serum panels for toxicology.&lt;/p&gt;Results:&lt;p&gt;The &lt;i&gt;in vivo&lt;/i&gt; whole-body imaging data detected widespread changes, where spatially heterogeneous toxic effects were identified across different tissues, within substructures of organs, as well as among different individuals. The signal changes were consistent with established toxicity profiles of these chemotherapeutic drugs. Apart from generating a map of susceptible tissues, this &lt;i&gt;in vivo&lt;/i&gt; imaging approach was more sensitive compared with conventional blood and serum markers used in toxicology. Also, repeated imaging during the acute period after drug treatment captured different kinetics of tissue injury among susceptible organs in males and females.&lt;/p&gt;Conclusions:&lt;p&gt;This novel and highly translational imaging approach shows promise in optimizing therapeutic decisions by detecting and managing drug toxicity on a personalized basis.&lt;/p&gt;&lt;p&gt;Toxicity to normal tissues is a significant limitation in chemotherapies. This work demonstrated an &lt;i&gt;in vivo&lt;/i&gt; imaging-based approach for characterizing toxicity-induced tissue injury in a systemic, dynamic, and near-real time fashion. This novel approach shows promise in optimizing therapeutic decisions by monitoring drug toxicity on a personalized basis.&lt;/p&gt;&lt;/div&gt;
Socio-economic Status of Deshi Muslims: A Case Study of Matia Community Development Block of Goalpara District, Assam, India (2016)

The socio-economic condition of individuals of any society is comprised of vast arena of subjects, and any rational being favours for their improvement.  Earning opportunities, educational attainment and health facilities are such indicators for an improved socio-economic condition of any community . Indeed their measurements is difficult, most of the social scientist have focused to concentrate on these prominent aspects to grasp, compare and contrast socio-economic condition of any group of people. Socio-economic condition being a complicated aspect, its realization rests on both qualitative and quantitative analysis. However, its assessment and analysis is necessary to diagnose for further improvement of quality of life of people. The holistic approach of Indian economy clearly indicated achieving the main objectives of rapid economic growth with social justice. After six decades of planning in India, living standard of average Indian has improved but certain groups of people in our community are lagged behind to cope with ongoing development activities. The Deshi Muslim community is an indigenous ethnic group of Assam. Traditionally, this section of people is rural based and primarily depends on Agriculture and other petty manual works for their livelihood. So, this section of people remains far behind to achieve educational attainment, realizing health facilities, earning opportunities etc. The idea of equality regarding socio-economic development among all sections of people seemed questionable in such situation.  To observe the reality in grassroots a micro level study is adopted. Therefore, a study entitled “Socio-economic Status of Deshi Muslims: A case study of Matia Community Development Block of Goalpara District, Assam, India” is adopted.
Maximizing the number of coexisting phases near invariant critical points for giant electrocaloric and electromechanical responses in ferroelectrics (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Z. K. Liu, Xinyu Li, Q. M. Zhang; Maximizing the number of coexisting phases near invariant critical points for giant electrocaloric and electromechanical responses in ferroelectrics. Appl. Phys. Lett. 20 August 2012; 101 (8): 082904. https://doi.org/10.1063/1.4747275 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Semi‐automated tandem mass spectrometric (MS/MS) triple quadrupole operating parameter optimization for high‐throughput MS/MS detection workflows (2009)

This paper describes an automated workflow for the determination of selected reaction monitoring (SRM) transitions and optimum mass spectrometric (MS) instrument parameters. The approach uses a Nanomate from Advion Biosciences for automated infusion of small amounts of sample in combination with Automaton optimization software from Sciex. The results are stored in the Analyst software Compound Database for automated acquisition method building. Comparisons are presented between the more traditional optimization methods of manual flow injection optimization, Autotune infusion optimization, Automaton flow injection optimization and the Nanomate-Automaton optimization approach. Data is also presented to show that acquisition methods developed on the Sciex model API3000 instrument can be effectively transferred to the Sceix API4000 and API5000 model instruments.
Cutaneous T-cell lymphoma cells employ a restricted range of T-cell antigen receptor variable region genes. (1990)

Monoclonal antibodies that recognize the proteins specified by two families of T-cell antigen receptor variable region genes were assessed as clonal markers in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). About 3% to 5% of tumors were expected to react with each antibody. However, 10 of 16 cases studied reacted with MAbs specific for the V beta 8 gene family. All the positive cases were examples of the plaque or tumor stages of CTCL. None of the cases of eczematoid or premycotic CTCL showed uniform reactivity with these antibodies. Unexpected use of one particular V gene family raises the possibility that CTCL derives from a distinct subpopulation of antigen- or virus-selected T cells.
Centralized Routing Control in BGP Networks Using Link-State Abstraction (2013)

Some operators deploy networks consisting of multiple BGP Autonomous-
Systems (ASNs) under the same administrative control. There are also
implementations which use only one routing protocol, namely BGP, as in
[I-D.lapukhov-bgp-routing-large-dc], for example. In such designs,
inter-AS traffic engineering is commonly implemented using BGP
policies, by configuring multiple routers at the ASN boundaries. This
distributed policy model is difficult to manage and scale due to its
dependency on complex routing policies and the need to develop and
maintain a model for per-prefix path preference signaling. One example
of such models could be standard BGP community-based (see [RFC1997])
signaling, which requires careful documentation and consistent
configuration. Furthermore, automating such policy configuration
changes for the purpose of centralized management requires additional
efforts and is dependent on a particular vendor's configuration
management (CLI extensions, NetConf [RFC6241] etc). This document
proposes a method for inter-AS traffic engineering for use with the
kind of deployment scenarios outlined above. No protocol changes or
additional features are required to implement this method. The key to
the proposed methodology is a new software entity called BGP
Controller - a special purpose application that peers with all eBGP
speakers in the managed network. This controller constructs live state
of the underlying BGP ASN graph and presents multi-topology view of
this graph via a simple API to third-party applications interested in
performing network traffic engineering. An example application could
be an operational tool used to drain traffic from network devices. In
response to changes in the logical network topology proposed by these
applications, the controller computes new routing tables, and pushes
them down to the network devices via the established BGP sessions.
A Novel Assay for Fungal Ketol-isomerase Activity. (2001)

2-Deoxy-D-glucose-6-phosphate ketol-isomerase (EC 2.6.1.16) forms glucosamine-6-phosphate and glutamate from fructose-6-phosphate and glutamine and plays an important role in chitin synthesis in fungi. We have established a new assay for fungal ketol-isomerase activity that is amenable to high throughput screening to identify enzyme inhibitors. Aspergillus fumigatus crude lysate was incubated with substrates and after incubation, reactions were terminated. Glutamate dehydrogenase, nitro blue tetrazolium chloride, phenazine methosulfate and beta-NAD were added and the amount of glutamate formed by ketol-isomerase activity was determined by measuring OD585nm. A feedback inhibitor, UDP-N-acetylglucosamine, of fungal ketol-isomerase was successfully detected by this assay (IC50=0.48 mM). In a pilot scale screening, an active extract from an extremophilic bacterium was found, and the extract showed antifungal activity against A. fumigatus, Candida albicans and C. glabrata.
Semiclassical statistical mechanics of a v-dimensional fluid of hard v-Spheres (1990)

The quantum corrections to the properties of a dense v-dimensional fluid of hard v-spheres are estimated at high temperature. Explicit expressions for the first quantum corrections to the free energy and equation of state are given. Numerical results are reported for hard v-spheres with 1 ˇ- v ˇ- 5. The behaviour of the radial distribution function near the hard core is also studied. A significant feature is the large increase in quantum correction with increasing dimensionality.