gebhart/patrepeval huggingface dataset:
Changes in Camera Visibility Affect Measured Marker Motion (2007)

Motion analysis is an important tool for biomechanical studies and its accuracy and reliability for large-volume applications, such as gait labs, is well-established. Previous work has offered a comparison of commercially available systems.[1] No work to date has quantified the error in position of a given tracking marker caused by its removal from the view of one or more cameras, either by obstruction or by the data being removed during the image reconstruction process. This issue is critical to the tracking of extremely fine movements such as the travel of the radial head on the capitellum during elbow motion. Due to anatomical constraints, markers must frequently be placed a distance away from the body of interest and must be smaller than those conventionally used in gross motion analysis. The nature of the motion may not permit all cameras to view all markers all of the time. For example, a specimen may itself obstruct a camera’s view during certain motions.
Conservation of functional domains involved in RNA binding and protein–protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1 (1998)

The modular structure of splicing factor SF1 is conserved from yeast to man and SF1 acts at early stages of spliceosome assembly in both organisms. The hnRNP K homology (KH) domain of human (h) SF1 is the major determinant for RNA binding and is essential for the activity of hSF1 in spliceosome assembly, supporting the view that binding of SF1 to RNA is essential for its function. Sequences N-terminal to the KH domain mediate the interaction between hSF1 and U2AF65, which binds to the polypyrimidine tract upstream of the 3' splice site. Moreover, yeast (y) SF1 interacts with Mud2p, the presumptive U2AF65 homologue in yeast, and the interaction domain is conserved in ySF1. The C-terminal degenerate RRMs in U2AF65 and Mud2p mediate the association with hSF1 and ySF1, respectively. Analysis of chimeric constructs of hSF1 and ySF indicates that the KH domain may serve a similar function in both systems, whereas sequences C-terminal to the KH domain are not exchangeable. Thus, these results argue for hSF1 and ySF1, as well as U2AF65 and Mud2p, being functional homologues.
Mehrgrößenregelung mit Entkopplung von Banddicke und Bandplanheit in 20-Rollen-Kaltwalzwerken (2011)

Zusammenfassung Die Produktion von Edelstahlfeinblech erfolgt meist an 20-Rollenwalzenwerken. Diese stellen komplexe und totzeitbehaftete Mehrgrößensysteme dar, bei denen Banddicke und Bandplanheit als wichtigste Qualitätsmerkmale in optimaler Weise geregelt werden müssen. Dabei ist die gegenseitige Kopplung zwischen den beiden Qualitätsgrößen, insbesondere bei festen und dünnen Bändern, zu berücksichtigen. Dieser Beitrag stellt eine integrierte Dicken- und Planheitsregelung basiert auf einem umfassenden Reglerentwurf vor, der die Querkopplungen zwischen beiden Regelgrößen berücksichtigt und kompensiert. Es handelt sich um eine Mehrgrößenregelung mit Entkopplung, wobei die Reglerparameter mit Hilfe der Online-Linearisierung eines physikalisch basierten Gerüstmodells adaptiert werden. Der Einsatz der Regelung an einem industriellen Sendzimir-Gerüst zeigt, dass alle Stellglieder mit maximaler Geschwindigkeit von der Regelung betätigt werden dürfen, ohne dass (wie bisher) negative Auswirkungen auf die jeweils andere Qualitätsgröße auftreten.
Extended eTVRA vs. security checklist: Experiences in a value-web (2009)

Security evaluation according to ISO 15408 (Common Criteria) is a resource and time demanding activity, as well as being costly. For this reason, only few companies take their products through a Common Criteria evaluation. To support security evaluation, the European Telecommunications Standards Institute (ETSI) has developed a threat, vulnerability, risk analysis (eTVRA) method for the Telecommunication (Telco) domain. eTVRA builds on the security risk management methodology CORAS and is structured in such a way that it provides output that can be directly fed into a Common Criteria security evaluation. In this paper, we evaluate the time and resource efficiency of parts of eTVRA and the quality of the result produced by following eTVRA compared to a more pragmatic approach (Protection Profile-based checklists). We use both approaches to identify and analyze risks of a new SIM card currently under joint development by a small hardware company and a large Telco provider.
Extending Chemoselective Ligation to Sugar Chemistry: Convergent Assembly of Bioactive Neoglycoconjugates (2003)

Glycoproteins and glycolipids play central roles in human health and disease, and their mimetics are primary candidates for drug development. Our understanding of the molecular level of phenomena based on molecular recognition of oligosaccharides by specific receptors has taken tremendous advantage from their chemical synthesis, which provides homogeneous material not attainable from biosynthetic systems. This review summarizes chemoselective approaches for the assembly of neoglycoconjugates. The objective of these methods is to make glycoconjugate synthesis accessible to a broader community, thus accelerating progress in biotechnology.
A device for separated and reversible co‐culture of cardiomyocytes (2010)

A novel technique is introduced for patterning and controllably merging two cultures of adherent cells on a microelectrode array (MEA) by separation with a removable physical barrier. The device was first demonstrated by separating two cardiomyocyte populations, which upon merging synchronized electrical activity. Next, two applications of this co-culture device are presented that demonstrate its flexibility as well as outline different metrics to analyze co-cultures. In a differential assay, the device contained two distinct cell cultures of neonatal wild-type and beta-adrenergic receptor (beta-AR) knockout cardiomyocytes and simultaneously exposed them with the beta-AR agonist isoproterenol. The beat rate and action potential amplitude from each cell type displayed different characteristic responses in both unmerged and merged states. This technique can be used to study the role of beta-receptor signaling and how the corresponding cellular response can be modulated by neighboring cells. In the second application, action potential propagation between modeled host and graft cell cultures was shown through the analysis of conduction velocity across the MEA. A co-culture of murine cardiomyocytes (host) and murine skeletal myoblasts (graft) demonstrated functional integration at the boundary, as shown by the progression of synchronous electrical activity propagating from the host into the graft cell populations. However, conduction velocity significantly decreased as the depolarization waves reached the graft region due to a mismatch of inherent cell properties that influence conduction.
EDEN: A High-Performance, General-Purpose, NeuroML-Based Neural Simulator (2022)

Modern neuroscience employs <i>in silico</i> experimentation on ever-increasing and more detailed neural networks. The high modeling detail goes hand in hand with the need for high model reproducibility, reusability and transparency. Besides, the size of the models and the long timescales under study mandate the use of a simulation system with high computational performance, so as to provide an acceptable time to result. In this work, we present EDEN (Extensible Dynamics Engine for Networks), a new general-purpose, NeuroML-based neural simulator that achieves both high model flexibility and high computational performance, through an innovative model-analysis and code-generation technique. The simulator runs NeuroML-v2 models directly, eliminating the need for users to learn yet another simulator-specific, model-specification language. EDEN's functional correctness and computational performance were assessed through NeuroML models available on the NeuroML-DB and Open Source Brain model repositories. In qualitative experiments, the results produced by EDEN were verified against the established NEURON simulator, for a wide range of models. At the same time, computational-performance benchmarks reveal that EDEN runs from one to nearly two orders-of-magnitude faster than NEURON on a typical desktop computer, and does so without additional effort from the user. Finally, and without added user effort, EDEN has been built from scratch to scale seamlessly over multiple CPUs and across computer clusters, when available.
KUAI-EXACT: a new approach for multi-valued logic minimization in VLSI synthesis (2003)

A new logic minimizer designed to generate the exact minimum solutions for multivalued input logic expressions is presented. The advantage of this minimizer is that it generates as few prime implicants as possible. A new algorithm is presented for directly generating essential prime implicants in a time close to that for generating a prime implicant by the ESPRESSO-MV expansion process. The authors discuss how to generate the secondary essential prime implicants in order to avoid setting up a covering table, and they present the corresponding algorithms for noncyclic functions. They also discuss the case in which a covering table should be created for obtaining an exact minimum solution and consider how to use the parallel processing techniques for the best speedup.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
115 The Impact of Burn Injury on Upper Extremity Prosthesis Users (2021)

Abstract Introduction Burns with upper extremity (UE) amputation present a unique rehabilitation challenge. The purpose of this study of UE amputees who are active prosthesis users was to compare outcomes for those with and without burns. Methods This is part of a larger nationwide study of U.S. military members and veterans with UE amputations. In-person data were collected at 5 sites. An therapist measured passive and active range of motion (PROM, AROM); administered the Quick Disability of the Arm, Shoulder, and Hand; Community Reintegration of Injured Service Members-Computer Adaptive-Test; Trinity Amputation and Prosthetic Experience Scale; health-related quality of life (VR-12); Activities Measure for Upper Extremity Amputees; Southampton Assessment Procedure; 9-Hole Peg Test; and Jebsen-Taylor Hand Function Test (JTHF); and recorded residual and phantom pain; timing of prosthesis receipt; and current prosthesis use. The IRB approved this study. Results Data were collected on 126 individuals with UE amputation, of whom 105 had data on etiology and were included. Of these, 13 (12.4%) had burns (B) vs non-burn (NB). The majority were unilateral amputees (69% B, 90% NB). Most were transradial (TR) amputees (B 84.6%, NB 66.3%) as opposed to transhumeral (TH). A minority received their prosthetics within the first 3 months post-amputation (11.1% B, 28.8% NB) (p=0.15). Average age was 57.6 (SD 15.6) years for NB and 53.0 (20.6) years for B. Mean time since amputation was 22.5 (18.0) years for NB and 25.2 (17.3) years for B. The following non-significant differences in outcomes between B and NB were observed. Thirty-nine percent of B were employed full-time vs 18.9% of NB (p=0.15). The primary prosthesis was, for NB, a body-powered prosthesis (66.7%); for B, myoelectric (50%) or body-powered (50%). For unilateral UE amputees, there were no differences between B and NB on performance testing for dexterity and functional tasks or in self-reported disability, quality of life or prevalence or intensity of pain. B trended towards more moderate to severe PROM deficits with shoulder forward flexion (TH B 50%, TH NB 23.1% [p=0.444]; TR B 20%, TR NB 5.6% [p=0.197]) and shoulder abduction (TH B 50%, TH NB 26.9% [p=0.497]; TR B 30%, TR NB 16.4% [p=0.376]). Also, TR amputees with burns trended towards more PROM deficits with elbow flexion (B 20%, NB 6.9% [p=0.212]) and elbow extension (B 20%, NB 8.6% [p=0.272]). AROM deficits also trended greater in B. Conclusions We did not observe differences in physical function, pain levels, or quality of life between those with and without burns. Further studies with larger samples are needed, to include analysis of burn location, burn size, hospital length of stay, and rehabilitation care.
Galactorrhoea: is it physiological. pharmacological or pathological? (2000)

While the occurrence of breast milk secretions at a time when a woman is not breastfeeding can occur in a large proportion of women, it can also be the first sign of a more significant endocrinopathy. Severity is not an indicator of the presence or absence of significant pathology and a practical approach is required to determine those disorders that have a physiological, pharmacological or pathological basis. (author abstract)
Electrically evoked compound action potentials are different depending on the site of cochlear stimulation (2016)

One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEX<sup>SOFT</sup> electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.
Very efficient myoblast allotransplantation in mice under FK506 immunosuppression (1994)

Transgenic CD1 mice expressing beta-galactosidase were used as myoblast donors. The myoblasts were injected in normal or mdx muscles previously irradiated and injected with notexin. Twenty-eight days after myoblast transplantation, the percentage of muscle fibers beta-glactosidase-positive was low in mice not immunosuppressed but was high (80%) in those treated with FK506. In mdx mice, muscle fibers expressing beta-galactosidase were also dystrophin positive. Most of the mice not treated with FK506 produced antibodies against the donor myoblasts. These results indicate that FK506 is a very useful immunosuppressive drug for myoblast transplantation in mice. Irradiation and notexin injection used in our experiments are, however, not feasible in humans. Other manipulations capable of increasing the participation of donor myoblasts to regeneration will therefore have to be identified before new clinical trials are attempted.
Doxycycline synergizes with doxorubicin to inhibit the proliferation of castration-resistant prostate cancer cells (2017)

Castration-resistant prostate cancer (CRPC) is fatal and there is currently no effective clinical treatment. The antibiotic doxycycline has shown anti-cancer effect in several kinds of solid tumors including prostate cancer. In this study, a combination of doxycycline and doxorubicin was used to investigate the synergistic effect on CRPC cells. MTT assay was employed to determine the viability of cells in two-dimensional (2D) cultures. Apoptosis was determined by Annexin V/propidium iodide (PI) double staining assay. Cell cycle was analyzed by PI staining, and reverse transcription-PCR (RT-PCR) was used to determine the expressions of apoptosis-related genes at mRNA level. Western blot analysis was used to analyze the expressions of Bcl-2, Bax, and Poly (ADP-ribose) polymerase proteins. Cytotoxicity assay and morphological observation of PC3 cells in three-dimensional (3D) cultures were used to determine the effect of combination treatment. Results showed that doxycycline combined with doxorubicin significantly inhibited PC3 cells in both 2D and 3D cultures, enhanced apoptosis, and increased the accumulation of cells in G2/M phase. RT-PCR showed down-regulation of Bcl-2 and up-regulation of Bax mRNA after combination treatment. Meanwhile, western blot analysis showed that combination treatment resulted in down-regulation of Bcl-2 protein and up-regulation of Bax protein, and that PARP cleavage was obviously exhibited after combination treatment. Confocal imaging analysis indicated that doxorubicin penetrated deeply into the core of spheroids when combined with doxycycline. These data indicated that doxycycline in combination with doxorubicin had a synergistic effect on PC3 cells and may provide a potential novel strategy for the treatment of CRPC.
Fault Detection Schemes for Continuous-Time Stochastic Dynamical Systems (2009)

In this paper the fault detection (FD) task in stochastic continuous-time dynamical systems is addressed. A new family of FD approaches is presented, which is based on the application of hypothesis testing on continuous-time estimators. The given FD schemes are widely analyzed in the framework of their characteristics, such as fault detectability, false alarms and missed detection. A collection of sufficient detectability conditions are given for a class of faults (referred here as generic), characterizing the faults which can be detected with certain formalized guarantee by the given FD schemes, and providing also an upper bound for the detection time in a probabilistic sense. The application and comparative performance of these FD approaches is illustrated for different faults in a simulation example.
CMOS-integrated geometrically tunable optical filters (2013)

We present a method for producing monolithically integrated complementary metal&#x2013;oxide&#x2013;semiconductor (CMOS) optical filters with different and customer-specific responses. The filters are constituted by a Fabry&#x2013;Perot resonator formed by two Bragg mirrors separated by a patterned cavity. The filter response can be tuned by changing the geometric parameters of the patterning, and consequently the cavity effective refractive index. In this way, many different filters can be produced at once on a single chip, allowing multichanneling. The filter has been designed, produced, and characterized. The results for a chip with 24 filters are presented.
An approach to software change management support (1997)

The process of software change is complex, and needs to be managed and assisted by automated tools. In this paper, we present an approach tosupporting software change management in software engineering environments. The major issues addressed include system representation, impact analysis and change propagation. In this approach, the change management activities are carried out on the original representation of software artifacts in the environment, rather than on a separate system model extracted. This enables assisted change propagation. We use both dependences and properties of software artifacts for impact analysis. Both impact analysis and change propagation areacombination of guided user intervention and automatic processing based on codi ed change patterns and propagation rules.
The 9th International Conference on Future Networks and Communications (FNC-2014) A framework for LTE-A Proximity-based Device-to-Device Service Registration and Discovery (2014)

Device-to-Device (D2D) communications in Long Term Evolution (LTE) networks has been proposed as a promising concept as part of the LTE-Advanced (LTE-A) framework, whose aim is to improve user experiences and resource utilization, taking advantage of users’ proximity to each other. In order to extend the current LTE-A system to support D2D communication, there is a need to work on enhancements on the network architecture level. In this paper, we survey the work proposed so far by researchers and propose a design that extends the Third Generation Partnership Project’s (3GPP) definition of proximity based services, descr ibing by this the necessary supporting elements.
Dynamic force microscopy analysis of nanocomposites, polymer blends, and block copolymers: Beyond imaging the surface morphology (2003)

International audience
Appearance product potential of plantation hardwoods from medium rainfall areas of the southern Murray-Darling Basin. Green product recovery (2000)

Summary The potential of plantation-grown Eucalyptus cladocalyx F Muell., E. globulus Labill. subsp. globulus, Corymbia maculata (Hook.) K. Hill & L. Johnson and E. sideroxylon Cunn. ex Woolls subsp. sideroxylon as a resource for high quality sawn products in the winter, medium rainfall zones (580–750 mm) of the southern Murray-Darling Basin were investigated in this study. Six plantations ranging in age from 15 to 40 years from within the region were selected for harvest. Sawing involved back-sawing strategies which have been shown to maximise the output of high quality products from small diameter eucalypts. To evaluate out-turns of appearance products and to assess the effect of tree growth characteristics (primarily branches, knots, kino and other characteristics) on sawn product appearance, green product quality and recovery were assessed using CSIRO appearance grading criteria. Evaluation of products was conducted in specific zones of the inner heartwood (within 50 mm of the pith) and outer heartwood (greater than 50 mm from the pith) and on a whole log basis. Based on green product appearance, good recoveries of high quality products were obtained for 36 to 40-year-old E. cladocalyx, 40-year-old C. maculata and 40-year-old E. sideroxylon. Alternatively, the potential for 15-year-old E. globulus and 26-year-old E. sideroxylon suggested that the potential would not be as good without some reduction in significant defects, particularly knots and kino. Knots were a major defect in sawn products from all plantations. Evaluation of boards from inner heartwood and outer heartwood zones showed that with the removal of knots an increase in recovery of products of select grade and better would be possible in the outer heartwood in all species. This indicates a potential improvement in product quality had mechanical pruning been employed. However, improvement in quality in C. maculata and E. cladocalyx would be modest after pruning because of good natural branch shedding characteristics in these species.
Assessment of rebound and relapse following ecallantide treatment for acute attacks of hereditary angioedema (2012)

Ecallantide was efficacious for treating acute HAE attacks. Relapse was observed in a small proportion of patients, and there was little evidence of rebound.