gebhart/patrepeval huggingface dataset:
Chemical basis underline the bioactivity fortification of licorice by honey-frying due to the natural deep eutectic solvent characteristics of honey (2021)

Abstract Background Honey has been widely used in medicine plants processing since ancient times. Honey-frying of herbal medicine is a well-known treatment in Chinese medicine. It has been reported that honey-frying can improve the immunomodulatory efficacy of licorice. However, it is still unknown why honey-frying improves the immunomodulatory activity of licorice. And our previous research demonstrated that honey has natural deep eutectic solvent (NADES) characteristics. NADES is a kind of solvent with broad polarity range and has attracted extensive attention of scholars in different fields. In the present study, we investigated chemical basis underline the possible potentiation of honey-frying on licorice to elucidate its chemical mechanism. Methods Firstly, immunological experiments were conducted to investigate whether the honey-processing could enhance the immunomodulatory efficacy of licorice. Then, the synergistic mechanism of honey-processed licorice was explored based on cell biological activity test, chemical composition test, bioavailability test, and Fourier transform-infrared (FT-IR) spectra. Results Pharmacological experiment verified that honey-processing enhanced the immunomodulatory efficacy of licorice. Moreover, honey increased the total flavonoid and polysaccharide contents in licorice decoction, improved the thermal stability and oral bioavailability of certain pharmacologically active constituents, and augmented their overall immunostimulatory functions. Similar effects of honey were also observed with NADES. The above effects are due to multiple molecular interactions between active compounds and sugar molecules of NADES. Conclusion These findings indicate that the biological activities of medicinal plants might be fortified by NADES/honey in the processing of the plant material. At the meantime, these findings provide theoretical and empirical basis for potential novel applications of honey or other NADESs at augmenting the health-promoting effects of medicinal plants.
Everolimus Long-Term Efficacy and Safety for the Treatment of Subependymal Giant Cell Astrocytoma (SEGA) Associated With Tuberous Sclerosis Complex (TSC) (S42.007) (2014)

OBJECTIVE: To examine the long-term efficacy and safety of everolimus, an oral mTOR inhibitor, for the treatment of SEGA associated with TSC using data from the open-label extension phase of the EXIST-1 trial (NCT00789828; data cutoff, 1/11/2013). BACKGROUND: TSC, an autosomal dominant genetic disorder, results in nonmalignant tumor growth in several organs throughout the body. In the brain, growth of SEGA may result in obstruction of cerebrospinal fluid flow, causing life-threatening hydrocephalus. EXIST-1, a randomized, double-blind, phase 3 trial, demonstrated that everolimus was superior to placebo for reducing SEGA volume in patients with TSC. DESIGN/METHODS: Patients (median age, 9.5 years [range, 0.8-26.6years]) received 4.5 mg/m2/day oral everolimus (n=78; titrated to a target trough 5-15ng/mL) or placebo (n=39). SEGA response rate (primary endpoint) was defined as proportion of patients with 蠅50% reduction in sum of volumes of all target SEGA (蠅1 SEGA 蠅1 cm in longest diameter) versus baseline. Adverse events (AEs) were monitored at every visit. RESULTS: Everolimus was superior to placebo for SEGA response rate (34.6% vs 0.0% P˂0.0001; original cutoff, 3/2/2011). Following positive results for the original cutoff, placebo patients were offered open-label everolimus in the study extension phase. As of 1/11/2013, 111 patients received 蠅1 dose of everolimus and were included in this extension analysis. Median treatment duration of everolimus was 29.3 months, and SEGA response rate was 48.6% (95% confidence interval [CI], 39.0-58.3%). As of 1/11/2013, median time to SEGA progression was not reached; however, SEGA progressions were observed for 9 (8.1%) patients. Most AEs were grade 1 or 2 and were similar to the original cutoff. The most frequent serious adverse events reported in ˃3% of patients were pneumonia (10.8%), pyrexia (4.5%), gastroenteritis (3.6%), and convulsion (3.6%). CONCLUSIONS: Everolimus continued to reduce SEGA volume with no new safety concerns. Study Supported by: Novartis Pharmaceuticals Corporation
Erosion‐dependant continuity development in high viscosity ratio blends of very low interfacial tension (2006)

Abstract This work studies continuity development and cocontinuity in high viscosity ratio EPDM/PP blends. A very low interfacial tension (0.3 mN/m) between the blend components together with high viscosity ratios (11 and 17) result in a variety of unusual morphological features, including isolated nanometer diameter fibers, very large particles, partially coalesced particles, and numerous particles interconnected by fibers. This unique combination of morphologies leads the blend to a novel and stable cocontinuous structure of partially coalesced particles and particles interconnected by fibers. Compared with low to medium viscosity ratio EPDM/PP blends, these cocontinuous networks demonstrate early percolation thresholds, rapid continuity development, and attain cocontinuity at lower compositions of minor phase. The slow surface erosion of the high viscosity EPDM phase during melt blending is shown to be responsible for the generation of these unusual morphological structures. Typically the timescale for erosion phenomena are so small that they have defied study in the mixing environment itself and typical blend morphology studies almost always examine the final steady‐state morphology obtained after several minutes of mixing. The combination of very low interfacial tension and very high viscosity ratios of these EPDM/PP systems provide a unique opportunity to examine erosion phenomena persisting over longer time scales during melt mixing. We propose a new concentration‐dependant erosion mechanism that is based on particle collision–coalescence–separation dynamics. The proposed conceptual mechanism is shown to dramatically accelerate the erosion process and maintain cocontinuity over prolonged periods of mixing. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 1919–1929, 2006
Age and Gender Differences in Emotion Recognition (2019)

The current study provided novel insights into the specific mechanisms that may explain differences in emotion recognition, examining how age and gender differences can be outlined by cognitive functioning and face exploration strategies.
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests (2010)

A 7-month-old male kitten was presented with chronic constipation and retarded growth. Clinical examination revealed disproportional dwarfism with mild skeletal abnormalities and a palpable thyroid gland. The presumptive diagnosis of congenital hypothyroidism was confirmed by low serum total thyroxine (tT(4)) concentration prior to and after the administration of thyroid stimulation hormone (TSH), increased endogenous TSH concentration and abnormal thyroid scintigraphic scan. The kitten had abnormal liver function tests and decreased insulin-like growth factor 1 (IGF-1) concentration, both of which returned to normal in correspondence with an improvement of the clinical signs after 6 weeks of thyroxine therapy. Congenital hypothyroidism is a rare disease that may present with considerable variation in clinical manifestation. In cases in which clinical signs are ambiguous, disorders such as portosystemic shunt and hyposomatotropism have to be taken into account as differential diagnosis. As hypothyroidism may be associated with abnormal liver function tests and low IGF-1 concentrations, test results have to be interpreted carefully.
Epitaxial hexagonal materials on IBAD-textured substrates (2023)

A multilayer structure including a hexagonal epitaxial layer, such as GaN or other group III-nitride (III-N) semiconductors, a <111> oriented textured layer, and a non-single crystal substrate, and methods for making the same. The textured layer has a crystalline alignment preferably formed by the ion-beam assisted deposition (IBAD) texturing process and can be biaxially aligned. The in-plane crystalline texture of the textured layer is sufficiently low to allow growth of high quality hexagonal material, but can still be significantly greater than the required in-plane crystalline texture of the hexagonal material. The IBAD process enables low-cost, large-area, flexible metal foil substrates to be used as potential alternatives to single-crystal sapphire and silicon for manufacture of electronic devices, enabling scaled-up roll-to-roll, sheet-to-sheet, or similar fabrication processes to be used. The user is able to choose a substrate for its mechanical and thermal properties, such as how well its coefficient of thermal expansion matches that of the hexagonal epitaxial layer, while choosing a textured layer that more closely lattice matches that layer.
Temperature and Growth Rate Effects on the hok/sok Killer Locus for Enhanced Plasmid Stability (1994)

The hok/sok locus, isolated from the multiple-resistance plasmid R1 of Escherichia coli, is very efficient at ensuring the stable maintenance of plasmids in Gram-negative systems by killing plasmid-free cells as they arise. To investigate independently the influence of temperature and growth rate on the effectiveness of hok/sok, continuous fermentations have been conducted with the pUC-based, IPTG-induced, beta-galactosidase expression vector pTKW106. At fixed temperature (37 degrees C), decreasing the dilution rate decreased plasmid stability, and at a fixed, low dilution rate (D = 0.15/h), decreasing the temperature resulted in an increase in plasmid stability. These trends are explained by the specific beta-galactosidase activity of each continuous fermentation: higher, specific, recombinant protein expression led to decreased plasmid stability (due to either segregational or structural instability, as determined by plasmid DNA isolation). A representative fed-batch medium produced more beta-galactosidase on a volumetric basis than M9C in the chemostat, and addition of the hok/sok locus increased segregational stability by 8-22-fold in continuous fermentations that lacked antibiotic selection pressure and in which beta-galactosidase was constantly expressed a 12% of total cell protein for 60 h (43-47 generations).
B‐cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement (1999)

Pectic polysaccharide fraction (BR-2) containing pharmacologically active pectic polysaccharide, bupleuran 2IIc, which was prepared from a medicinal herb, the roots of Bupleurum falcatum L., was administered orally to C3H/HeJ mice for 7 consecutive days. Proliferative responses of spleen cells were enhanced in the presence of the purified pectic polysaccharide, bupleuran 2IIc, but another B-cell mitogen, lipopolysaccharide (LPS) did not give a similar effect. In vitro studies using spleen cells showed that bupleuran 2IIc also stimulated lymphocytes, depleted of adherent cells or T cells. Bupleuran 2IIc treatment increased subpopulation of CD25+ and surface immunoglobulin M-positive (sIgM+) lymphocytes. Non-specific immunoglobulin secretion of spleen cells treated with bupleuran 2IIc was increased according to the culture time, and coexistence of interleukin-6 (IL-6) enhanced the secretion more than that of bupleuran 2IIc alone. These results suggest that bupleuran 2IIc proliferates B cells in the absence of macrophages, and the resulting activated B cells are then induced into antibody-forming cells in the presence of IL-6. Among the structural region of bupleuran 2IIc, ramified region (PG-1), which consists of rhamnogalacturonan core rich in neutral sugar chain, showed the potent mitogenic activity suggesting it to be an active site. Mitogenic activity of bupleuran 2IIc was reduced in the presence of antipolysaccharide antibody (antibupleuran 2IIc/PG-1-IgG), which recognizes the ramified region of bupleuran 2IIc as the antigenic epitope. Mitogenic activity of bupleuran 2IIc was also reduced by the addition of beta-d-GlcpA-(1-->6)-beta-d-Galp-(1-->6)-d-Galp or beta-d-GlcpA-(1-->6)-d-Galp, which are a part of the epitopes of antibupleuran 2IIc/PG-1-IgG. These results suggest that the epitopes in bupleuran 2IIc act as active sites of the polysaccharide during mitogenic activity.
Association of an activator with an RNA polymerase II holoenzyme. (1995)

RNA polymerase II holoenzymes have been described that consist of RNA polymerase II, a subset of general transcription factors, and four SRB proteins. The SRB proteins, which were identified through a selection for genes involved in transcription initiation by RNA polymerase II in vivo, are a hallmark of the holoenzyme. We report here the isolation and characterization of additional SRB genes. We show that the products of all nine SRB genes identified thus far are components of the RNA polymerase II holoenzyme and are associated with a holoenzyme subcomplex termed the mediator of activation. The holoenzyme is capable of responding to a transcriptional activator, suggesting a model in which activators function, in part, through direct interactions with the holoenzyme. Immunoprecipitation experiments with anti-SRB5 antibodies demonstrate that the acidic activating domain of VP16 specifically binds to the holoenzyme. Furthermore, the holoenzyme and the mediator subcomplex bind to a VP16 affinity column. These results provide a more complete description of the RNA polymerase II holoenzyme and suggest that this form of the transcription apparatus can be recruited to promoters via direct interactions with activators.
Transition-Metal-Free Stereoselective and Regioselective Hydroamination of 2-Benzoylethynyl-4,5,6,7-tetrahydroindoles with Amino Acids (2012)

A new family of unnatural amino acids possessing a tetrahydroindole moiety is obtained by nucleophilic addition of various amino acids to the triple bond of 2-benzoylethynyl-4,5,6,7-tetrahydroindoles. The reaction proceeds chemo-, regio- and stereospecifically in the presence of sodium hydroxide to give the <i>Z</i>-isomeric products in 35–72% yields.
Control of Non-Ferrous Electric Arc Furnaces (1997)

An important aspect of non-ferrous metal production is the separation process known as smelting, in which the concentrated ore is melted and separated into two components of different densities: the slag and the matte. The smelting process is carried out through high-power heating in electric arc furnaces. In order to maintain a constant desired matte production rate and constant matte and slag temperatures, the average furnace power must be accurately controlled and coordinated with the concentrate feed rate. This paper presents power control technologies for high power smelting furnaces. Power quality and management issues are also briefly discussed.
Duplex cyclodextrin (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDuplex cyclodextrinIwao Tabushi, Yasuhisa Kuroda, and Kazuhiro ShimokawaCite this: J. Am. Chem. Soc. 1979, 101, 6, 1614–1615Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ja00500a052https://doi.org/10.1021/ja00500a052research-articleACS PublicationsRequest reuse permissionsArticle Views409Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Biological Evaluation of 5-Formyl-6-arylimidazo(2,1-b)-1,3,4-thiadiazole-2-N-(dimethylaminomethino)sulfonamides as Antitumor Agents (2011)

In search for potential anti cancer drug candidates in imidazo (2,1-b)-1,3,4-thiadiazole series, two series of 5-formyl-6-arylimidazo(2,1-b)-1,3,4-thiadiazole-2-N- (dimethylaminomethino) sulfonamides and 5-bromo-6-aryl/ethylacetateimidazo(2,1-b)-1,3,4- thiadiazole-2-sulfonamides were synthesised. All compounds showed significant cytotoxic effects (log10 GI50 < -4.0, log molar drug concentration required to cause 50% growth inhibition) against a variety of human tumor cell lines of the National Cancer Institute in vitro screen, including cells derived from solid tumors such as non-small cell lung, colon, central nervous system, melanoma, ovarian, prostate and breast cancer, and also few cell lines of leukemia and renal cancer. Introduction of a formyl group at the 5- and substituted aromatic group at 6-position generated compounds with potent antitumor activity. Incorporation of a bromo at 5- and ester group at 6-position produced compounds with reduced activity.
Unobserved classes and extra variables in high-dimensional discriminant\n analysis (2021)

In supervised classification problems, the test set may contain data points\nbelonging to classes not observed in the learning phase. Moreover, the same\nunits in the test data may be measured on a set of additional variables\nrecorded at a subsequent stage with respect to when the learning sample was\ncollected. In this situation, the classifier built in the learning phase needs\nto adapt to handle potential unknown classes and the extra dimensions. We\nintroduce a model-based discriminant approach, Dimension-Adaptive Mixture\nDiscriminant Analysis (D-AMDA), which can detect unobserved classes and adapt\nto the increasing dimensionality. Model estimation is carried out via a full\ninductive approach based on an EM algorithm. The method is then embedded in a\nmore general framework for adaptive variable selection and classification\nsuitable for data of large dimensions. A simulation study and an artificial\nexperiment related to classification of adulterated honey samples are used to\nvalidate the ability of the proposed framework to deal with complex situations.\n
Determination of collagen degradation products in human urine in osteoarthrosis. (1988)

A new method for profiling human urine has been developed. Peptides of molecular weight greater than 10,000 were separated by high-performance liquid chromatography with fluorescence monitoring (excitation 297 nm, emission filter 389 nm) adjusted for detection of collagen cross-linking compound pyridinoline. The collagen origin of some peptides was confirmed by determination of hydroxyproline in their hydrolysates. Peak heights were substantially higher in patients with osteoarthrosis than at healthy controls. After replacement of the diseased joint by total endoprosthesis the chromatograms changed and were similar to those of healthy controls.
Square Root Marginalization for Sliding-Window Bundle Adjustment (2021)

In this paper we propose a novel square root sliding-window bundle adjustment suitable for real-time odometry applications. The square root formulation pervades three major aspects of our optimization-based sliding-window estimator: for bundle adjustment we eliminate landmark variables with nullspace projection; to store the marginalization prior we employ a matrix square root of the Hessian; and when marginalizing old poses we avoid forming normal equations and update the square root prior directly with a specialized QR decomposition. We show that the proposed square root marginalization is algebraically equivalent to the conventional use of Schur complement (SC) on the Hessian. Moreover, it elegantly deals with rank-deficient Jacobians producing a prior equivalent to SC with Moore–Penrose inverse. Our evaluation of visual and visual-inertial odometry on real-world datasets demonstrates that the proposed estimator is 36% faster than the baseline. It furthermore shows that in single precision, conventional Hessian-based marginalization leads to numeric failures and reduced accuracy. We analyse numeric properties of the marginalization prior to explain why our square root form does not suffer from the same effect and therefore entails superior performance.
687: Combined Angiopoietin-1 and Vascular Endothelial Growth Factor Gene Transfer Restores Cavernous Angiogenesis and Erectile Function in a Rat Model of Hypercholesterolemia (2006)

You have accessJournal of UrologyPodium, Monday, May 22, 2006 10:00 am - 12:00 pm1 Apr 2006687: Combined Angiopoietin-1 and Vascular Endothelial Growth Factor Gene Transfer Restores Cavernous Angiogenesis and Erectile Function in a Rat Model of Hypercholesterolemia Ji-Kan Ryu, Chung-Hyun Cho, Hwa-Yean Shin, Sun U. Song, Seung-Min Oh, Shuguang Piao, Jee-Young Han, Gou Young Koh, and Jun-Kyu Suh Ji-Kan RyuJi-Kan Ryu More articles by this author , Chung-Hyun ChoChung-Hyun Cho More articles by this author , Hwa-Yean ShinHwa-Yean Shin More articles by this author , Sun U. SongSun U. Song More articles by this author , Seung-Min OhSeung-Min Oh More articles by this author , Shuguang PiaoShuguang Piao More articles by this author , Jee-Young HanJee-Young Han More articles by this author , Gou Young KohGou Young Koh More articles by this author , and Jun-Kyu SuhJun-Kyu Suh More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32933-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "687: Combined Angiopoietin-1 and Vascular Endothelial Growth Factor Gene Transfer Restores Cavernous Angiogenesis and Erectile Function in a Rat Model of Hypercholesterolemia." The Journal of Urology, 175(4S), pp. 222–223 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 222-223 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ji-Kan Ryu More articles by this author Chung-Hyun Cho More articles by this author Hwa-Yean Shin More articles by this author Sun U. Song More articles by this author Seung-Min Oh More articles by this author Shuguang Piao More articles by this author Jee-Young Han More articles by this author Gou Young Koh More articles by this author Jun-Kyu Suh More articles by this author Expand All Advertisement PDF downloadLoading ...
Gas-liquid partition chromatography: the separation of volatile aliphatic amines and of the homologues of pyridine (1952)

column under these circumstances is lower (
Signal Integrity and Power Integrity Properties of FCBGA Based on Ultra-Thin, High-Density Packaging Substrate (2005)

We developed an ultra-thin high-density packaging substrate, called an MLTS (multi-layer thin substrate), that consists only of build-up layers without a core laminate. We evaluated the signal integrity and power integrity properties of a flip-chip ball grid array (FCBGA) based on the MLTS, along with those of an identically functioning FCBGA based on conventional build-up printed wiring board (PWB). Our signal-integrity simulation clearly showed that the return loss (S11) of the MLTS was 6 dB smaller than that of the PWB in the frequency range from 1 to 10 GHz. In our power-integrity simulation, the noise transmitted inside the MLTS was 13 dB smaller than that inside the PWB at 10 GHz. These results indicate that the MLTS has considerable advantages over a conventional build-up PWB, especially for operation in the GHz range.