gebhart/patrepeval huggingface dataset:
Abstract 11809: Impact of Strong Lipophilic Statin on Left Ventricular Properties and the Incidence of Atrial Fibrillation in Elderly Patients With Hypertension; A Prospective Four-Years Study (2014)

Background: Strong lipophilic statins may attenuate cardiac hypertrophy. We assessed the hypothesis that a strong lipophilic statin (pitavastatin) could prevent left atrial (LA) remodeling and new-onset atrial fibrillation (AF) through preservation of diastolic function and lowering of pulmonary capillary wedge pressure (PCWP) in hypertension (HTN). Methods: Elderly patients with HTN and left ventricular ejection fraction (LVEF) > 50% but no history of AF were prospectively enrolled and divided to 2 groups: HTN with statin (n=140, age 72±5) and HTN without statin (n=234, age 73±6). LA volume (V), emptying function (EF), strain, strain rate (SR), stiffness and PCWP were obtained by speckle tracking echocardiography. PCWP was estimated as 10.7 - 12.4 x log (active LAEF / minimum LAV), as we previously reported. LA stiffness was defined as PCWP / LA strain. LV mass, LVEF and E/e’ were measured. All patients were followed for 4 years. Results: There were no differences in BP, cholesterol or LVEF between the 2...
Parasites and Cancers: Parasite Antigens as Possible Targets for Cancer Immunotherapy (2012)

An adverse relationship between some parasite infections and cancer in the human population has been reported by different research groups. Anticancer activity of some parasites such as Trypanosoma cruzi, Toxoplasma gondii, Toxocara canis, Acantamoeba castellani and Plasmodium yoelii has been shown in experimental animals. Moreover, it has been shown that cancer-associated mucin-type O-glycan compositions are made by parasites, therefore cancers and parasites have common antigens. In this report anticancer activities of some parasites have been reviewed and the possible mechanisms of these actions have also been discussed.
P1‐452: Analysis of axonal transport of APP in JIP1 gene‐deficient mice (2008)

JNK-interacting proteins (JIPs) are scaffolding molecules which are thought to regulate JNK signaling pathway. We previously identified JIP1b, the splicing variant of JIP1 which posesses phosphotyrosine interaction (PI) domain as well as JNK-binding domain, as a factor that associates with the cytoplasmic domain of APP and stabilizes its metabolism (J. Biol. Chem. [2002] 277, 20070; J. Biol. Chem. [2002] 277, 27567). Recently, we demonstrated that JIP1b plays an important role in the connection of APP to kinesin-1 and the anterograde transport of APP in neuron (EMBO J. [2007] 26, 1475). Moreover, we found that suppression of APP transport by inhibiting the interaction of APP with kinesin-1 motor through JIP1b increased β-amyloid (Aβ) generation. However, the role and molecular mechanism of JIP1b in APP transport remained to be unclear in detail. Here we investigated the role of JIP1b in axonal transport of APP in detail with JIP1-deficient mutant (JIP1-/-) mice. APP-GFP fusion proteins were expressed in primary cultured cortical neurons derived from wild-type and JIP1 (-/-) mice, and axonal transport of APP-containing vesicles was observed using a total internal reflectance fluorescence (TIRF) microscopy. We examined the velocities and the rates of anterograde transport of APP-containing vesicles. The velocity and frequency of anterograde transport of APP-containing vesicles in neurons of wild-type and JIP1-/- mice were examined and compared. APP was subjected to anterograde transport in axon even in the absence of JIP1, but it was very inefficient when compared with the APP transport in wild-type neuron. Our observations suggest that JIP1 is an important role in the effective transport of APP-containing vesicles anterogradely. Because the deficiencies of axonal transport system and suppression of anterograde transport of APP increase the generation of Aβ, which is one of the major cause of Alzheimer's disease, analyzing the regulatory mechanism of APP connection to kinesin-1 motor is important for understanding of AD pathogenesis.
11C-methane production in small volume, high pressure gas targets (2000)

The parameters affecting the production of 11 C-methane, in situ, in small volume, high-pressure gas targets include target chamber size and material. The results are based on experiments that varied the target gas composition, the target material and geometry. Methane production yields were typically 65% of the yields of 11 CO 2 in the same target chamber.
Merely Entertaining a Thought, Judging and Asserting (2013)

What are Frege’s views on the mental acts of merely entertaining a thought and judging and on the illocutionary act of asserting, and to what extent, if any, do they withstand critical scrutiny? In this paper I want to contribute to the ongoing discussion of these questions by commenting on a highly pertinent passage in Frege’s 1918 essay ‘Der Gedanke’.1 Here is the first half of that passage. (The translation is my own, and you will soon see why it had to be.)
Helium leak test for sterility assurance of a sealed bag. I: Relationship of helium leak and pinhole diameter. (2002)

Described herein is an attempt to establish a simpler, more reliable method to maintain the aseptic condition of bulk materials of drug substances. The method would be used in the manufacturing process of our "double-bag" kit system for infusion, which has two compartments, one for the infusion liquid and another for the drug product. To manufacture the kit system, we used a flexible inner container to enclose the bulk under aseptic conditions and a method for ensuring sterility of the container. We used an aluminum laminate bag as the inner container, which was then enclosed in a polyethylene bag. To detect tears or pinholes in the bag, a helium leak test was evaluated. First, a simple experimental model of helium leakage from bags was established. In the model, a pinhole was made in a film disk of the aluminum laminate or polyethylene material used for the inner and outer bags. A helium leak detector was used to measure the escape of helium through the pinhole, and the leak could be detected from a pinhole from 10 microns in diameter. As the bulk product was doubly sealed in an aluminum bag and a polyethylene bag in the manufacturing process to maintain an aseptic condition, we also checked for helium leak from pinholes of film disks after connecting two film disks. The results showed that helium leak was detectable when the pinhole diameters of both film disks were more than 20 microns. Clearly, helium leak is strongly affected by pinhole diameter in both experimental models. We have calculated, for the pinhole geometries studied, helium leak rates by using the Poiseuille Equation. Calculated values were in agreement with experimental values.
Extraction of major acidic Ca2+ dependent phosphoproteins from synaptic membranes (1988)

The association of several phosphoproteins with the synaptosomal plasma membrane (SPM) was investigated by phosphorylating SPM fractions from neonatal rat brain in the presence of Ca2+ and then exposing these to a variety of agents. Extraction of the major acidic phosphoproteins, GAP-43, pp40, and pp80, was assessed by two-dimensional gel electrophoresis and fluorography. All three proteins were best extracted from the membrane by high pH and by guanidine hydrochloride. GAP-43 was not extracted in the presence of either low- or high-ionic-strength buffers, reducing agents, or chelating agents; pp80 and pp40, however, showed a significant extraction even under low-ionic-strength conditions. Partition experiments with Triton X-114 revealed an amphiphilic behavior for GAP-43 and a strong affinity for hydrophobic environments for pp80 and pp40. None of the phosphoproteins was released from the membrane by the use of a phosphatidylinositol-specific phospholipase C. The extraction properties of GAP-43, pp80, and pp40 are similar to those of known extrinsic membrane proteins and therefore suggest that these phosphoproteins are peripheral rather than integral to the membrane compartment.
Resilience Analysis of a Localization Solution for Railway and Tramway Vehicles under Failures in GPS Measurement Data Acquisition (2022)

In this paper, a localization solution for railway and tramway vehicles, relying on low-cost on-board sensor technology and on a Kalman-based data fusion scheme, is tested against failures in GPS measurement acquisition. Such failures can be caused by either non-favorable operating conditions (e.g, the presence of tunnels), or intentional/accidental service disruptions. Our analysis, carried out through simulation of a three-dimensional multi-body vehicle, highlights failure conditions under which the localization solution is shown to be resilient with respect to an acceptable performance level, as well as situations that the original framework is not able to cope with. In the latter case, a variant solution, still based on low-cost on-board technology, is shown to be able to recover satisfactory performance.
Crystal Structure of the Photocycloaddition of 1-(4’-Bromophenyl)-2-phenyl-3-ethoxycarbonyl-D2-pyrroline-4,5-dione with Styrene (1976)

The structure of the cycloadduct of 1-[4 -bromophenyl]-2-phenyl-3-ethoxycarbonyl-~'-~~rroline-4,5-dione with styrene was determined by X-ray analysis using a heavy atom method.In preceding paper we showed that 2 -p h e n y l -3 -e t h o x y c a r b o n y l - 2 A-pyrroline-4.5-dione reacts with the olefins carrying electron 2 rich substituents to give [2+2] cycloadducts .For determination of regio-and stereochemistry of the products, w e chose the cycloadduct of 1-[41-bromophenyl1-2-phenyl-3-ethoxycarbonyl-~2-pyrro-
The Use of Oxytocin to Improve Feeding and Social Skills in Infants With Prader–Willi Syndrome (2017)

OXT is well tolerated in infants with PWS and improves feeding and social skills. These results open perspectives for early treatment in neurodevelopment diseases with feeding problems.
Large-diameter holographically corrected membrane telescope (2002)

Next generation space telescopes with apertures >10m will require novel technologies to permit lightweight primaries to operate at the diffraction limit in the optical regime. One solution is to construct a telescope from a lightweight, membrane primary, which is holographically corrected for surface distortions, <i>in situ</i>. We have demonstrated the correction of >10,000 waves of error in a 1-m diameter primary having an areal mass of just 17 grams per square meter.
Reversible Description of Asphaltene Colloidal Association and Precipitation (2002)

Asphaltene in crude oil and in other apolar solvents has intriguing solubility properties which indicate colloidal aggregation. However, none of the various models proposed so far is capable of accounting consistently for all properties. In the present article, we reconsider the current literature and list all robust experimental features redundantly reported on asphaltene solubilization. Then we build a new description, demanding that it should not be contradicted by any one of these listed facts. In our description, asphaltene aggregation and precipitation are distinct steps in a completely reversible process. Aggregation proceeds from specific strong interaction sites located at the periphery of the asphaltene molecules: they drive the reversible association in two-dimensional sheets, a morphology which is consistent with reported scattering and viscosity data. Precipitation eventually occurs, determined by van der Waals attractions between aggregates, when the solubility parameter of the solvent is shifted. One major interest of our description is that it accounts for the remarkable solubilizing properties of the “resins” within a completely reversible scheme.
Unbiased Stereology: Three-Dimensional Measurement in Microscopy (1998)

Concepts Random sampling and random geometry Estimation of reference volume using the cavalieri method Estimation of component volume and volume fraction Number estimation Estimation of total surface area and surface density Length estimation Stere
[Oxyhemoglobin dissociation curve and 2,3-diphosphoglycerate in chronic hypoxemia]. (1991)

The measurement of the oxyhemoglobin dissociation curve (ODC) and 2,3-diphosphoglycerate (2,3-DPG) in patients with chronic hypoxemia is important from the view point of tissue oxygenation. However, there have been no consistent results that explain the relation among chronic hypoxemia, 2,3-DPG and P50, which is oxygen pressure at an oxygen saturation of 50 percent. The aim of this study is to clarify what factors affect P50 and 2,3-DPG. 1) Patients with chronic hypoxemia, who showed PaO2 less than 60 Torr, had significantly higher P50 than normal subjects. 2) The concentration of Hb showed significant negative correlation with both P50 and 2,3-DPG. 3) Arterial blood pH showed significant positive correlation with both P50 and 2,3-DPG. 4) In a group with normal levels of Hb and pH, there was significant negative relationship between PaO2 and P50. 5) In a group with normal levels of Hb and pH, there was significant positive relationship between PaCO2 and P50. 6) In a group with normal levels of Hb, pH and PaCO2, there was significant negative relationship between PaO2 and 2,3-DPG. In conclusion, P50 and 2,3-DPG are affected largely by Hb concentration or blood pH, with or without hypoxemia. However there is a mechanism by which P50 and 2,3-DPG are increased by hypoxemia itself in a group with normal levels of Hb, pH and PaCO2.
2D Solid-State NMR Analysis of Inclusion in Drug–Cyclodextrin Complexes (2012)

The solubility of drug molecules can often be improved through preparation and delivery of cyclodextrin (CD) inclusion complexes. These drug-oligosaccharide complexes can be prepared in solution and converted to the solid state via methods such as lyophilization and spray-drying, or they can be prepared directly from solids by a variety of methods. The development of drug-CD complexes as solids allows for potential advantages in dosage form design, such as the preparation of layered formulations, and it also can yield improvements in chemical and physical stability. 2D solid-state NMR (SSNMR) methods provide a direct way to probe drug-CD interactions in solid complexes through dipolar interactions between nuclei within the drug and CD molecules. In this study, 2D heteronuclear and homonuclear correlation SSNMR experiments involving (1)H, (13)C, (19)F, and (31)P nuclei are used to demonstrate the inclusion of drug within the CD cavity in a variety of powder samples. To illustrate the general applicability of the SSNMR approach presented, examples are shown for the drugs diflunisal, adefovir dipivoxil, voriconazole, dexamethasone, and prednisolone in complexes with α-CD, β-CD, and sulfobutylether-substituted β-CD. The quantitative analysis of included and free drug fractions in a solid drug-CD complex using SSNMR is also demonstrated. On the basis of these results, general approaches to the characterization of these materials using SSNMR are proposed.
Towards a human eye behavior model by applying Data Mining Techniques on Gaze Information from IEC (2008)

In this paper, we firstly present what is Interactive Evolutionary Computation (IEC) and rapidly how we have combined this artificial intelligence technique with an eye-tracker for visual optimization. Next, in order to correctly parameterize our application, we present results from applying data mining techniques on gaze information coming from experiments conducted on about 80 human individuals.
Mapping the Urban Lead Exposome: A Detailed Analysis of Soil Metal Concentrations at the Household Scale Using Citizen Science (2018)

An ambitious citizen-science effort in the city of Indianapolis (Indiana, USA) led to the collection and analysis of a large number of samples at the property scale, facilitating the analysis of differences in soil metal concentrations as a function of property location (i.e., dripline, yard, and street) and location within the city. This effort indicated that dripline soils had substantially higher values of lead and zinc than other soil locations on a given property, and this pattern was heightened in properties nearer the urban core. Soil lead values typically exceeded the levels deemed safe for children’s play areas in the US (&amp;lt;400 ppm), and almost always exceeded safe gardening guidelines (&amp;lt;200 ppm). As a whole, this study identified locations within properties, and cities, that exhibited the highest exposure risk to children, and also exhibited the power of citizen science to produce data at a spatial scale (i.e., within a property boundary) that is usually impossible to feasibly collect in a typical research study.
Optimizing IPOG's Vertical Growth with Constraints Based on Hypergraph Coloring (2017)

In this paper, we present an optimization of IPOG's vertical growth phase in the presence of constraints. The vertical growth problem is modeled as a classical NP-hard graph problem called "Minimum Vertex Coloring". In the graph model, vertices are either missing tuples that are waiting to be colored or existing tests that are already colored in different colors at the initial state, edges/hyperedges are conflicts among vertices that cannot be put in a same test. After coloring, a group of vertices in same color can be transformed to exactly a valid test. Since the original IPOG algorithm uses an arbitrary order to cover missing tuples during vertical growth, in order to reduce the number of tests, we compute the Degree of Conflicts (DOC) for each tuple, and cover the tuples in the non-increasing order of DOC. We implement a new IPOG algorithm incorporating this optimization. The experimental results show that the new IPOG algorithm reduces the number of tests for many real-life systems with constraints.
Celebrity Endorsement in India: Pattern and Trends (2016)

The adoption of celebrities by Indian advertising agencies has experienced a tremendous increase in the last 15 years. Celebrity advertisement is considered as an effective communication strategy between the marketer and consumers. A good number of companies have adopted this strategy as an effective tool to penetrate the product in to the different segment of the market. The paper attempts to evaluate the pattern and trends in celebrity endorsement in India. The products are classified into five categories like medicine and toiletries, drinks and confectionery, personal appearances, home appliances and miscellaneous items. A sample of 125 advertisements belongs to five product categories featuring celebrities were considered and study reveals that film stars are frequently used as endorsers and dominated all product categories.
Photoluminescence characterization of GaAs quantum well laser structure with AlAs/GaAs superlattices waveguide (1992)

Dependence on the excitation power and temperature of the photoluminescence emission of GaAs quantum well laser structures using GaAs/AlAs superlattices in the waveguide is reported. The effects related to a quality reduction due to the presence of a thick ternary AlGaAs cladding layer in the bottom of the laser structure were elucidated by comparing to the photoluminescence of a similar waveguide structure, except for the AlGaAs bottom layer. The excitation power dependence shows the strong excitonic origin of the light emission in the temperature range 4–300 K in both structures. Carrier transport mechanisms through the superlattices is analyzed from the evolution of the photoluminescence of the quantum well and the superlattice confining layers; a structure dependent transparency temperature is defined, at which transport changes from tunneling assisted to extended minibands regime. The value of this parameter depends on the localized states in the superlattice minibands, caused by interface roughness.
GDFs promote tenogenic characteristics on human periodontal ligament-derived cells in culture at late passages (2013)

Tendon/ligament injures are leading disabilities worldwide. The periodontal ligament (PDL) connects teeth to bone, and is comparable to a tendon/ligament-to-bone insertion. PDL-derived cells (PDLCs) express both osteo/cementogenesis and teno/ligamentogenesis genes. However, an efficient method to induce a tenogenic differentiation of PDLCs has not been thoroughly examined. Therefore, this study tested if growth/differentiation factors (GDFs) enhanced tenogenic characteristics of human PDLCs, as a potential cell source for tendon/ligament engineering. Results demonstrated recombinant GDF-5/GDF-7 inhibited alkaline phosphatase (ALP) activity of PDLCs from passage 3 to 6, while GDF-5 enhanced ALP in dental pulp-derived cells and mesenchymal stem cells. GDF-5 (particularly at 10 ng/ml concentration) induced high expression of both early (scleraxis) and mature (tenomodulin, aggrecan, collagen3) tenogenic genes in P4-6 PDLCs, while inhibiting expression of specific transcription-factors for osteogenic, chondrogenic and adipogenic differentiation. Exogenous GDFs might lead PDLCs being expanded in culture during several passages to highly useful cell source for tendon/ligament engineering.
Characterization of pit oil from Montmorency cherry (Prunus cerasus L.) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of pit oil from Montmorency cherry (Prunus cerasus L.)Amitabh. Chandra and Muraleedharan G. NairCite this: J. Agric. Food Chem. 1993, 41, 6, 879–881Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jf00030a007https://doi.org/10.1021/jf00030a007research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The CRISPR System Protects Microbes against Phages, Plasmids (2009)

Many scientists believe that phages are the most abundant life form on Earth. Although phages outnumber their bacterial prey 10-fold, bacteria persist, sometimes relying on clustered regularly interspaced short palindromic repeats (CRISPRs) of DNA sequence as a defense mechanism. CRISPRs, first recognized in Escherichia coli in 1987, are found within the genomes of about 40% of bacteria and 90% of archaea tested so far.
Analysis of deployment dependencies in software components (2006)

Administration and deployment of software systems become increasingly complex. This complexity results from the need of uniform access to applications from heterogeneous terminals through different communication infrastructures. Moreover, applications consists in complex architectures of lot of small components connected together. A first step to simplify deployment is to have an unified and abstract model for representing deployment dependencies and managing them properly. Therefore, we propose here a deployment model and a conceptual foundation for component installation. Installation dependencies and installation rules are expressed in a logic language.