gebhart/patrepeval huggingface dataset:
Combating infectious diseases in aquaculture with an original probiotic product (2015)

Oyster production in Rhode Island accounts for over $2.5 million in annual revenue, making it the top aquaculture product in the state. However, larval tank infections significantly constrain production and create substantial economic losses for commercial hatcheries. In most cases antibiotics may not be used to prevent or treat larval tank infections. A probiotic, or beneficial microbe which competes with pathogens, is a safer and “green” approach to preventing infections. Vibriosis, a common cause of oyster larval mortality, is the result of Vibrio species infections. Previous studies have shown that a native Rhode Island microbe, Bacillus pumilus RI06-95, protects oyster larvae against infection by the pathogen Vibrio tubiashii RE22. In this study, a freeze-dried formulation of this probiotic agent was evaluated for use in commercial hatchery tanks. Stability, dispersion and pilot-scale hatchery studies were performed to evaluate this product. A viability analysis of the freeze-dried product over time revealed that when stored at 4 ºC, the product will maintain viable probiotic cells at greater than the minimum effective concentration, 108 CFU/mL per single-use tube, for at least two months. The dispersion of this product in seawater was investigated using light microscopy, and qualitatively showed that the product readily and rapidly disperses within 30 seconds, without any shaking or added energy. A pilot-scale hatchery study revealed that the freeze-dried product increased survival of three-day-old and eight-day-old larvae after challenged with Vibrio tubiashii RE22 by 26 % (± 15 %) and 47 % (± 28 %) respectively, compared to larvae which received no probiotic treatment. Based on these results, we conclude that our freeze-dried formulation of Bacillus pumilus RI06-95 is a stable, easy-to-use, safe and efficacious probiotic product for sustainable oyster aquaculture.
Exploring Ovarian Cancer Cell Resistance to Rhenium Anticancer Complexes (2020)

Abstract Rhenium tricarbonyl complexes have been recently investigated as novel anticancer agents. However, little is understood about their mechanisms of action, as well as the means by which cancer cells respond to chronic exposure to these compounds. To gain a deeper mechanistic insight into these rhenium anticancer agents, we developed and characterized an ovarian cancer cell line that is resistant to a previously studied compound [Re(CO) 3 (dmphen)(ptolICN)] + , where dmphen=2,9‐dimethyl‐1,10‐phenanthroline and p tolICN= para ‐tolyl isonitrile, called TRIP. This TRIP‐resistant ovarian cancer cell line, A2780TR, was found to be 9 times less sensitive to TRIP compared to the wild‐type A2780 ovarian cancer cell line. Furthermore, the cytotoxicities of established drugs and other rhenium anticancer agents in the TRIP‐resistant cell line were determined. Notably, the drug taxol was found to exhibit a 184‐fold decrease in activity in the A2780TR cell line, suggesting that mechanisms of resistance towards TRIP and this drug are similar. Accordingly, expression levels of the ATP‐binding cassette transporter P‐glycoprotein, an efflux transporter known to detoxify taxol, were found to be elevated in the A2780TR cell line. Additionally, a gene expression analysis using the National Cancer Institute 60 cell line panel identified the MT1E gene to be overexpressed in cells that are less sensitive to TRIP. Because this gene encodes for metallothioneins, this result suggests that detoxification by this class of proteins is another mechanism for resistance to TRIP. The importance of this gene in the A2780TR cell line was assessed, confirming that its expression is elevated in this cell line as well. As the first study to investigate and identify the cancer cell resistance pathways in response to a rhenium complex, this report highlights important similarities and differences in the resistance responses of ovarian cancer cells to TRIP and conventional drugs.
GMPLS-Based Multi-Ring Metro WDM Networks employing OTN-Based Client Interfaces for 1OGbE Services (2007)

Direct 10 GbE LANPHY transport over GMPLS-controlled multi-WDM rings interconnected by a WXC was firstly investigated using DWDM-colored interfaces with OTN framing on IP/MPLS routers. Full-wire-rate client signal transportation and OTN-based multi-ring management was successfully confirmed.
Modélisation de la propagation des ondes élastiques dans les structures stratifiées composites (2007)

International audience
Feature-based model selection for object detection from point cloud data (2022)

Smart monitoring using three-dimensional (3D) image sensors has been attracting attention in the context of smart cities. In smart monitoring, object detection from point cloud data acquired by 3D image sensors is implemented for detecting moving objects such as vehicles and pedestrians to ensure safety on the road. However, the features of point cloud data are diversified due to the characteristics of light detection and ranging (LIDAR) units used as 3D image sensors or the install position of the 3D image sensors. Although a variety of deep learning (DL) models for object detection from point cloud data have been studied to date, no research has considered how to use multiple DL models in accordance with the features of the point cloud data. In this work, we propose a feature-based model selection framework that creates various DL models by using multiple DL methods and by utilizing training data with pseudo incompleteness generated by two artificial techniques: sampling and noise adding. It selects the most suitable DL model for the object detection task in accordance with the features of the point cloud data acquired in the real environment. To demonstrate the effectiveness of the proposed framework, we compare the performance of multiple DL models using benchmark datasets created from the KITTI dataset and present example results of object detection obtained through a real outdoor experiment. Depending on the situation, the detection accuracy varies up to 32% between DL models, which confirms the importance of selecting an appropriate DL model according to the situation.
Intra-molecular Electronic Energy Transfer in Mono- and Di-nuclear Zinc(II) Supramolecular Complexes (2002)

Intra-molecular electronic energy transfer processes have been investigated in systems containing two distinct fluorophores Fl 1 (absorbing photonic energy) and Fl 2 (coumarin 343, brought at a close distance through coordinative interactions, emitting). Fl 1 is covalently linked or incorporated in a polyamine platform containing one or two Zn II ions, while Fl 2 coordinates the Zn II centre(s) through a carboxylate group. Zn II has been chosen for its photophysical inactivity and quick reversibility of the interaction with Fl 2 .
Medical Visualization for Orthopedic Applications (2006)

This dissertation discusses visualization techniques of articular cartilage for both quantitative and qualitative assessment.Articular cartilage is a very thin structure covering the endings of human bones.Thus, even slight changes in its thickness and inner structure may indicate an occurrence or progress of degeneration.The early detection of these factors is crucial for diagnosis and treatment of cartilage degeneration.Research to find treatments to stop or even reverse these degenerative changes is well in progress.Magnetic resonance imaging is currently the best and most used non-invasive technique for acquisition of soft tissue structures like articular cartilage.In this work we use two types of data: a high-resolution anatomical scan of the cartilage and a T 2 map, which is computed from a set of sequences with varying parameters.While the thickness of the data can be precisely assessed from the anatomical scan, the T 2 map offers information on the inner structures of the cartilage.Since the femoral cartilage is a curved thin-wall structure with a relatively small extent in one direction, it is very difficult to estimate its thickness from a stack of slices or even from a three-dimensional reconstruction of its surface.We discuss inspection of the tissue by unfolding and, thus, representing the tissue as a two-dimensional height field.Such a transformation of the object enables the application of 2D geometrical operations in order to observe subtle details in the thickness of the tissue.Nowadays scanners allow a quality assessment checking disruptions in the pattern of the T 2 map of the patellar cartilage.The T 2 map illustrates the quality of the cartilage and changes in the pattern of T 2 map indicate defects before changes in the thickness itself occur.We propose the Profile Flags -an intuitive interface for probing of the T 2 maps by browsing the reconstructed surface of the cartilage.The Profile Flag is positioned on the reconstructed surface of the tissue, and can be moved along it.The Profile Flags can be applied to annotate local as well as global characteristics of the underlying data in a single still image.Furthermore, we present a set of extensions to Profile Flags for selection, classification and automatic positioning.Profile Flags can also be used to measure time-varying dynamic contrast enhanced magnetic resonance imaging data.i This work has been greatly supported by the following people: First of all, I would like to thank MEISTER Eduard Grller, whose inspiration, experience and trust were very important for
Antioxidants Produced byEurotium herbariorumof Filamentous Fungi Used for the Manufacture of Karebushi, Dried Bonito (Katsuobushi) (2009)

Extracts prepared by culturing ten filamentous fungi from Aspergillus and Eurotium species isolated from dried bonito (katsuobushi) were examined for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity. The extracts prepared by culturing E. herbariorum NE-1 and NE-4, which are used in the molding process for the manufacture of karebushi (a kind of katsuobushi), were shown to have higher activity than the others. Five antioxidants were isolated from the extracts and identified as isodihydroauroglaucin (IDAG), auroglaucin (AG), dihydroauroglaucin (DAG), tetrahydroauroglaucin (TAG), and flavoglaucin (FG) by (1)H-NMR, (13)C-NMR, and EI-MS analyses. Compared with alpha-tocopherol, the isolated antioxidants exhibited high antioxidative activity for the radical scavenging capacity of DPPH and superoxide, but low activity for inhibiting the autoxidation of docosahexaenoic acid (DHA). The isolated antioxidants were produced by the Eurotium species, but not by the Aspergillus species. DAG and TAG exhibited higher radical scavenging capacity than the other antioxidants and were abundantly contained in the extracts of E. herbariorum NE-1 and NE-4.
Shape-memory polymers (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
<title>Advanced IFSAR for search and rescue</title> (1999)

One of the most promising tools for airborne SAR search and rescue is the use of interferometric techniques such as wavenumber filtering. These techniques make possible extremely accurate information extraction from SAR image pairs. The potential gain in accuracy is significant, since accuracy of measurements can theoretically be determined to within a wavelength (centimeter accuracy) as opposed to a pixel distance (meters). This paper presents the latest interferometric SAR (IFSAR) processing algorithms developed by the authors, along with examples of their use on actual data.
Formulating the Architectural Design of Enterprise Applications as a Search Problem (2005)

Software architecture design is widely recognized to be a complex task. This is especially true when designing enterprise applications that require deciding about a number of architectural design issues, often involving selecting among various design alternatives that impact differently on a set of quality attributes. In order to facilitate the selection process, earlier research efforts have already investigated the use of quantitative decision-making methods for scoring and ranking design alternatives. These methods, however, treat individual architectural decisions independently without considering their synergistic interrelationships. We argue that many architectural decisions are highly interdependent with each other, and thus need to be treated jointly in the selection process. To support this claim, we have identified two types of dependencies that can occur among different design decisions. We show that in particular situations, these dependencies require employing unconventional methods in determining the appropriate design solution. For this purpose, we suggest formulating the architectural design task as a search problem, and also show how search trees can be useful in this regard. We apply these ideas on a financial system, in order to demonstrate their applicability in a real setting.
<title>Dynamic Computer Generated Displays For Study Of The Human Left Ventricle</title> (1973)

Many specific diagnoses of diseases of the heart can be obtained in cardiac catheterization laboratories. Dynamic changes in volume and distributions of coronary blood flow are studied by means of injecting roentgen-opaque (i.e., x-ray dense) material into the left ventricle or the right ventricle through a catheter whose tip has been threaded into the heart via a puncture in a peripheral vein or artery such as femoral artery in the leg. At the time of the injection of contrast media, the chest of the patient is irradiated with x-ray and dynamic movements of the opacified heart are projected onto a&apos;fluoro scopic screen and then recorded on videotape by a television system or on film by a photographic system. Although cine roentgenography (that using film) can have higher spatial and temporal resolution (Ref. 1) than video roentgenography (that using television), the cine systems require a longer time to complete the diagnosis since the film must be developed.
Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus (1988)

The distribution of neural inputs to the paraventricular (PVH) and supraoptic (SO) nuclei from the regions of the A1, the A2, and the A6 (locus coeruleus) noradrenergic cell groups was investigated by using a plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L), as an anterogradely transported tracer. An immunofluorescence double-labeling procedure was used to determine the extent to which individual anterogradely labeled fibers and terminals in the PVH and the SO also displayed immunoreactive dopamine-beta-hydroxylase (DBH), a marker for catecholaminergic neurons. The results may be summarized as follows: (1) Projections from the A1 region were found primarily, and in some experiments almost exclusively, in those parts of the magnocellular division of the PVH and the SO known to contain vasopressinergic neurons. (2) Projections from the A2 region were distributed primarily throughout the parvicellular division of the PVH and were most dense in the dorsal medial part, a region known to contain a prominent population of corticotropin-releasing factor (CRF)-immunoreactive neurons. In addition, a less-dense projection to the magnocellular division of the PVH and to the SO was consistently found. (3) Fibers originating from the locus coeruleus were distributed almost exclusively to the parvicellular division of the PVH, with the most prominent input localized to the periventricular zone, a part of the PVH known to contain dopamine-, somatostatin-, and thyrotropin-releasing-hormone-containing neurons. We found no evidence for a projection from A6 to the SO. (4) The majority of fibers originating from the A1, the A2 or the A6 regions contained DBH immunoreactivity, although an appreciable number did not. These results suggest that each of the three brainstem noradrenergic cell groups that contribute to the innervation of the PVH and/or the SO is in a position to modulate the activity of anatomically and chemically distinct groups of neurosecretory neurons.
Two-dimensional real-time ultrasonic imaging of the heart and great vessels. Technique, image orientation, structure identification, and validation. (1978)

Conventional M-mode echocardiography has become established as a diagnostic tool for noninvasive evaluation of cardiovascular diseases. Now the advent of two-dimensional real-time echocardiography has opened a new era of investigation. This paper describes in detail the technique of a complete two-dimensional ultrasonic examination of the heart and great vessels. Four transducer locations were commonly utilized--namely, parasternal, apical, subxiphoid, and suprasternal notch positions. The tomographic sections of the heart obtained along the long and short axes of the heart and great vessels by utilizing the above positions were validated by detailed anatomic and contrast echocardiographic techniques.
Automated cellular pathology in noninvasive confocal microscopy (2014)

A computer algorithm was developed to automatically identify and count melanocytes and keratinocytes in 3D reflectance confocal microscopy (RCM) images of the skin. Computerized pathology increases our understanding and enables prevention of superficial spreading melanoma (SSM). Machine learning involved looking at the images to measure the size of cells through a 2-D Fourier transform and developing an appropriate mask with the erf() function to model the cells. Implementation involved processing the images to identify cells whose image segments provided the least difference when subtracted from the mask. With further simplification of the algorithm, the program may be directly implemented on the RCM images to indicate the presence of keratinocytes in seconds and to quantify the keratinocytes size in the en face plane as a function of depth. Using this system, the algorithm can identify any irregularities in maturation and differentiation of keratinocytes, thereby signaling the possible presence of cancer.
Differential diagnoses of solitary and multiple pigmented lesions of the oral mucosa: Evaluation of 905 specimens submitted to histopathological examination (2021)

Oral pigmented lesions are a rare diagnosis in oral pathology and solitary lesions are more commonly submitted to biopsy. Some key features help in the differential diagnosis, though biopsy can be warranted in doubtful cases.
Optimizing an Emergency Medical Dispatch System to Improve Prehospital Diagnosis and Treatment of Acute Coronary Syndrome: Nationwide Retrospective Study in China (2022)

The optimized use of MPDS in China was associated with increased diagnosis consistency and a reduced call-to-EMS arrival time among EMS-treated patients with ACS. An emergency medical dispatch system should be designed specifically to fit into different prehospital modes in the EMS system on a regional basis.
Full‐wave‐equation depth migration using multiple reflections (2010)

We present a migration method in the temporal frequency domain that can propagate both downgoing and upgoing waves. The method can handle arbitrary velocity model, and we demonstrate its ability to image overturned events and steep reflectors. Our algorithm has the advantage of migrating the data sequentially in depth and frequency, leading to significant advantages compared to Reverse Time Migration when combined with migration velocity analysis. We also show that the method can easily generate offset and angle gathers.
Handbook on the Physics and Chemistry of Rare Earths (1988)

The first volumes of the Handbook on the Physics and Chemistry of Rare Earths were published in 1978 and 1979. Since then, approximately one volume per year has been published, making a total of 15 volumes to date, containing 104 chapters with little duplication of topics covered. Some of the discoveries of marked technological importance of the 1980s include the excellent permanent magnetic properties of the Nd-Fe-B alloys, the magneto-optic behaviour of Co (or Fe)-Gd (or Tb) amorphous thin films, and the existence of superconductivity at temperatures well above liquid nitrogen (77 K) in YBa2Cu3O7-x; and these topics have been reviewed in some of the 104 chapters. To increase the usefulness of this serial publication, this volume contains comprehensive subject and author indexes for the whole series, up to and including volume 15. The value of the index volume has been enhanced by the inclusion of a comprehensive tabulation of most of the physical properties of the rare earth metals (14 tables). Also included is an errata listing all corrections of mistakes discovered while compiling this index, and those errors pointed out by authors, editors and users of the Handbook.
Global immunoglobulin supply: steaming towards the iceberg? (2020)

There is a significant geographical imbalance in global supply of plasma with 65% collected in the United States. This results in a dependency of other countries on United States supply and argues for both more plasma supply and greater regionally balanced plasma collection. In addition, progress towards a transparent, regulated and well tolerated framework for the coexistence of unpaid and compensated plasma donations is needed as unpaid donation will not be sufficient. These discussions should be informed by the needs of patients for this life-saving therapy, the care of donors and the safety of plasma and PDMPs.
Aerobic vaginal pathogens and their sensitivity pattern. (2009)

The high prevalence of gynaecological infections demands that the patients with gynaecological symptoms be investigated thoroughly. Culture must invariably be done. Currently the antibiotics showing good sensitivity are very expensive. So there is a need for an effective antimicrobial policy. Effective drug should be reserved for the treatment of serious life threatening situations only.
Improvement of Immune-Complex Nephritis Associated with Hepatitis B Surface Antigen Excess (1989)

A case of hypocomplementemic membranoproliferative glomerulonephritis was studied during remission of nephrosis induced by high doses of corticosteroids. Hepatitis B surface antigen (HBsAg) and immune complexes were detected in serum and glomeruli. Anti-hepatitis-B surface antibody, undetectable in serum by conventional radioimmunoassays was identified in circulating immune complexes (CIC). On two occasions, improvement in renal function coincided paradoxically with an extreme increase in serum HBsAg levels as well as with marked elevation of CIC. We suggest that, as previously observed in animal models of glomerulonephritis, extreme antigen excess may inhibit glomerular deposition of immune complexes.
Ribosome-independent peptide synthesis in nature and their application to dipeptide production (2008)

While the ribosome system is the major equipment for peptide bond formation in nature, various ribosome-independent peptide-bond forming activities also exist. These activities are not only responsible for the syntheses of specific peptides but also involved in the biosynthesis of cofactors and nucleic acid and in the processes of protein breakdown. In this review, the ribosome-independent activities are overviewed and recent attempts to apply the activities in dipeptide production are introduced.
A practical approach to ultrasonic imaging using diffraction tomography (1988)

A technique for ultrasonic imaging based on the theory of diffraction tomography is presented. The method utilizes a fixed, circular configuration of transmitters and detectors. This configuration was selected because it avoids many practical limitations associated with the design of a medical imaging device. Practical considerations also motivated the inclusion of effects associated with the transmitter beam pattern rather than pursuing the more conventional approach in which plane-wave illumination is required. In addition, the problem of separately imaging both density and compressibility variations is considered.