gebhart/patrepeval huggingface dataset:
Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity (2005)

Coumarins, also known as benzopyrones, are present in remarkable amounts in plants, although their presence has also been detected in microorganisms and animal sources. The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins, such as furocoumarins and pyranocoumarins. Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. Furthermore, they have been reported to have multiple biological activities (anticoagulant, anti-inflammatory), although all these properties have not been evaluated systematically. In addition, their enzyme inhibition properties, antimicrobial and antioxidant activities are other foremost topics of this field of research. The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscoumarins and triscoumarins. Data are also highlighted, concerning the development of new synthetic strategies that could help in drug design and in the work on SAR or QSAR.
Obesity genetics: insights from the Pakistani population (2017)

The Pakistani population is extensively diverse, indicating a genetic admixture of European and Central/West Asian migrants with indigenous South Asian gene pools. Pakistanis are organized in different ethnicities/castes based on cultural, linguistic and geographical origin. While Pakistan is facing a rapid nutritional transition, the rising prevalence of obesity is driving a growing burden of health complications and mortality. This represents a unique opportunity for the research community to study the interplay between obesogenic environmental changes and obesity predisposing genes in the time frame of one generation. This review recapitulates the ancestral origins of Pakistani population, the societal determinants of the rise in obesity and its governmental management. We describe the contribution of syndromic, monogenic non-syndromic and polygenic obesity genes identified in the Pakistani population. We then discuss the utility of gene identification approaches based on large consanguineous families and original gene × environment interaction study designs in discovering new obesity genes and causal pathways. Elucidation of the genetic basis of obesity in the Pakistani population may result in improved methods of obesity prevention and treatment globally.
A Prolyl Endopeptidase-Inhibiting Benzofuran Dimer from Polyozellus multiflex (2001)

A new benzofuran dimer, 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC(50) value of 1.14 microM. Kynapcin-24 was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.
Car Interior Radar for Advanced Life-Signs Detection (2022)

European source with RF performance allowing low-power designs with operating frequencies beyond 100GHz (∼120 GHz) based on 2FDX technology for the first time. A thin RADAR IC for 120 GHz applications will be embedded in cavities of a silicon base wafer and/or into novel glass-based interposer structures and electrically interconnected to an antenna that is located directly aside the IC. RF circuits for IC, antenna and interconnects will be co-designed by 3D full wave EM simulations. This approach enables RF simulation and optimization of the whole IC/antenna package before manufacture. The use of standard semiconductor technology for the RF package on wafer-level ensures very high precision of interconnect geometry and optimum electrical performance. The entire system consists of an analog radar frontend implementing antennas in innovative mass volume packaging solution; assembled to a board (PCB) with additional functionality realizing the demonstrator sensor system. The radar signal processing instance will be used to process the data stream of sensor PCB in order to provide sensor data results to backend systems. The demonstrator will showcase a mm-wave radar solution operating beyond 100GHz (∼120 GHz) installed in a real vehicle environment.
A Series of Phthalocyaninotin Complexes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Series of Phthalocyaninotin ComplexesWilliam J. Kroenke and Malcolm E. KenneyCite this: Inorg. Chem. 1964, 3, 2, 251–254Publication Date (Print):February 1, 1964Publication History Published online1 May 2002Published inissue 1 February 1964https://pubs.acs.org/doi/10.1021/ic50012a025https://doi.org/10.1021/ic50012a025research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vibrationally hot emission and electronic relaxation of CO in Ne matrix (1988)

Vibrational progressions due to radiative decay of A 1Π (v′=0, 2, 3 5, 6, 8), e 3∑ (v′=0, 3, 5, 12), a′ 3∑ (v′=5, 14), d 3Δ (v′=3, 5), a 3Π (v′=0, 1, 2) to the ground state and of e 3∑ (v′=3, 5, 7, 9, 11, 12) and d 3Δ (v′=3, 7, 11) to the a 3Π state have been observed for selective excitation of A 1Π (v′=0, . . . ,8). The intersystem crossing rate constants, the bottle necks, pathways and rate constants for internal conversion in the triplet levels and the triplet–singlet radiative rate constants are explained by an intramolecular mixing of electronic states and electron–phonon coupling with the matrix.
Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients (2008)

These results suggest that specific fimA genotypic clones, which are reportedly associated with periodontitis, are also frequently harbored in cardiovascular specimens, indicating the possible involvement of type II and IV clones in the initiation and progression of cardiovascular diseases.
Optically induced flat bands in twisted bilayer graphene (2020)

Twisted bilayer graphene exhibits strong electronic correlations at the ``magic angle'' -- a special angle of the twist, at which isolated flat bands emerge in the material's band structure. The authors present here a new mechanism to induce isolated flat bands at angles below the magic angle using visible/infrared light. This mechanism enables optical control of the flatness, spectral isolation, and topological properties of the bands, using frequencies which are well below the material's bandwidth. Floquet engineering using optical fields and moir\'e superlattices may therefore play an important role in the exploration of on-demand nonequilibrium quantum phases of matter.
[p-Sulfotetrafluorophenyl hydrophilic activated esters of amino acids in peptide synthesis]. (1995)

Highly reactive hydrophilic (i.e., water-soluble) p-sulfotetrafluorophenyl esters (Tfs esters) are proposed for peptide synthesis in aqueous and aqueous-organic media, as well as for protein and peptide partial synthesis in an aqueous medium. These esters can serve as a basis for creating a series of protein modifying reagents. As they are analogs of the widely used pentafluorophenyl esters, the Tfs esters possess a high reactivity coupled with good stability during storage. The expression for the reaction rate (for substrates AA1 and AA2) is shown to be v = k[Boc-AA1-OTfs][H-AA2-NH2]0.5 for both water and DMF, i.e., the reaction is not a simple second-order reaction. The reaction rate in water is only slightly lower than that in DMF.
Methotrexate pharmacokinetics in childhood acute lymphoblastic leukaemia: a prognostic value ? (2010)

Serum concentrations and pharmacokinetic parameters of MTX are not associated with outcome in ALL. Prognoses based on single-drug pharmacokinetic estimates within a complex multiple-agent protocol appear to be unreliable. However, therapeutic drug monitoring of high-dose methotrexate remains a useful tool for early detection of impaired elimination and for avoiding systemic toxicity.
Steric Gate Variants of UmuC Confer UV Hypersensitivity onEscherichia coli (2009)

Y family DNA polymerases are specialized for replication of damaged DNA and represent a major contribution to cellular resistance to DNA lesions. Although the Y family polymerase active sites have fewer contacts with their DNA substrates than replicative DNA polymerases, Y family polymerases appear to exhibit specificity for certain lesions. Thus, mutation of the steric gate residue of Escherichia coli DinB resulted in the specific loss of lesion bypass activity. We constructed variants of E. coli UmuC with mutations of the steric gate residue Y11 and of residue F10 and determined that strains harboring these variants are hypersensitive to UV light. Moreover, these UmuC variants are dominant negative with respect to sensitivity to UV light. The UV hypersensitivity and the dominant negative phenotype are partially suppressed by additional mutations in the known motifs in UmuC responsible for binding to the beta processivity clamp, suggesting that the UmuC steric gate variant exerts its effects via access to the replication fork. Strains expressing the UmuC Y11A variant also exhibit decreased UV mutagenesis. Strikingly, disruption of the dnaQ gene encoding the replicative DNA polymerase proofreading subunit suppressed the dominant negative phenotype of a UmuC steric gate variant. This could be due to a recruitment function of the proofreading subunit or involvement of the proofreading subunit in a futile cycle of base insertion/excision with the UmuC steric gate variant.
Immunological Responses and Long-Term Treatment Interruption after Human Immunodeficiency Virus Type 1 (HIV-1) Lipopeptide Immunization of HIV-1-Infected Patients: the LIPTHERA Study (2008)

We studied the time course of immunological and virological markers after highly active antiretroviral therapy (HAART) interruption in chronically human immunodeficiency virus type 1 (HIV-1)-infected patients immunized with an HIV lipopeptide preparation. In a prospective open pilot study, 24 HIV-1-infected HAART-treated patients with undetectable plasma viral loads (pVLs) and CD4(+) T-cell counts above 350/mm(3) were immunized at weeks 0, 3, and 6 with a candidate vaccine consisting of six HIV lipopeptides. At week 24, patients with pVLs of <1.7 log(10) copies/ml were invited to stop taking HAART. Antiretroviral therapy was resumed if the pVL rose above 4.47 log(10) copies/ml and/or if the CD4(+) cell count fell below 250/mm(3). Immunological and virologic parameters were studied before and after HAART interruption. The median baseline and nadir CD4(+) cell counts were 482 (interquartile range [IQR], 195 to 826) and 313 (IQR, 1 to 481)/mm(3), respectively. New specific CD8(+) cell responses to HIV-1 epitopes were detected after immunization in 13 (57%) of 23 assessable patients. Twenty-one patients were evaluated 96 weeks after HAART interruption. The median time to pVL rebound was 4 weeks (IQR, 2 to 6), and the median peak pVL was 4.26 (IQR, 3 to 5) log(10) copies/ml. Thirteen of these 21 patients resumed HAART a median of 60 weeks after immunization (IQR, 9.2 to 68.4 weeks), when the median pVL was 4.8 (IQR, 2.9 to 5.7) log(10) copies/ml and the median CD4(+) cell count was 551 (IQR, 156 to 778)/mm(3). Eight patients were still off therapy at 96 weeks, with a median pVL of 4 (IQR, 1.7 to 4.6) log(10) copies/ml and a median CD4(+) cell count of 412 (IQR, 299 to 832)/mm(3). No clinical disease progression had occurred. Despite the lack of a control arm, these findings warrant a randomized study of therapeutic vaccination with HIV lipopeptides followed by long-term HAART interruption in AIDS-free chronically infected patients.
A small chip size 2 W, 62% efficient HBT MMIC for 3 V PCN applications (1998)

This work describes the L-band low voltage (/spl ges/1.6 V) power performance of AlGAs/GaAs heterojunction bipolar transistors (HBTs), their modeling and the design of a 2-W monolithic microwave integrated circuit (MMIC) for 3-V wireless mobile PCN applications (1800 MHz). The two-stage MMIC achieves 62% power-added efficiency (PAE) and 33 dB of linear gain, at a very small chip size of 1.2 mm/sup 2/. To our knowledge this is the best combination of power performance data for wireless applications demonstrated so far for a MMIC. The chip size is about a factor of four smaller than comparable MMIC's known before. The MMIC offers the potential both for low cost production due to small chip size, single voltage supply, and high performance at the same time.
Mobility of elements released from coal during CO<SUB align="right">2 sequestration (2019)

A key greenhouse emission reduction strategy is to sequestrate CO2 in the subsurface by injecting it into coal seams. We investigated the injection of CO2 into coal seams using static batch experiments conducted under similar temperature and pressure conditions to that of the formation from which the coal samples were originally obtained, in an effort to understand the mobilisation of elements released from the coal. Anthracite and high volatile bituminous coal samples (4-8 mm in size) were exposed to a solution of supercritical CO2 (ScCO2) and water at a temperature of approximately 40°C and a pressure of 9.8 MPa. The results obtained indicate that elements show different mobilities after exposure to the ScCO2-H2O solution. Their mobilities are mainly influenced by the occurrence of the elements in the coal minerals. It was found that the mobilisation of elements associated with carbonate minerals was greater than that of elements associated with sulphide and sulphate minerals; which was in turn greater than that of elements associated with silicate minerals. The results also show that close attention should be paid to the potential environmental hazards that might arise if the elements are released into groundwater systems during the CO2 sequestration process. [Received: December 16, 2015; Accepted: June 18, 2017]
Studies on the Metabolism of C19‐Steroids in Rat Liver (1968)

The formation of androstanetriols after incubation of testosterone with 105,000 × g microsomes of adult male rat liver was investigated. The steroids were isolated by thin‐layer chromatography and were identified by gas chromatography‐mass spectrometry as 5α‐androstane‐2β,3α,17β‐triol, 5α‐androstane‐3α,7α,17β‐triol and 5α‐androstane‐3α(and 3β),16α,17β‐triol. Incubation of 2β‐ and 7α‐hydroxytestosterone only gave androstanetriols with a 3α‐configuration while incubation with 6β‐ and 16α‐hydroxytestosterone resulted in the formation of both the 3α‐ and 3β‐epimers of the respective androstanetriols. After incubation with 5α‐dihydrotestosterone the following androstanetriols were isolated: 5α‐androstane‐2β,3α(and 3β),17β‐triol, 5α‐androstane‐3α(and 3β),7α,17β‐triol and 5α‐androstane‐3α(and 3β),16α,17β‐triol. No steroid with a 6β‐hydroxy group could be isolated after this incubation. When 5α‐androstane‐3α,17β‐diol was incubated only 5α‐androstane‐2β,3α,17β‐triol was formed, and 5α‐androstane‐3β,17β‐diol was not hydroxylated in the microsomes. These findings indicate a substrate specificity for the 2β‐, 6β‐, 7α‐ and 16α‐hydroxylases. After incubation of testosterone with 105,000 × g liver microsomes from male germfree rats the same metabolites were isolated as after incubation with microsomes from conventional rats.
Extracorporeal Shock Wave Therapy and a New Assessment Tool for Intractable Wounds of the Limbs (2023)

Background: Extracorporeal shock wave therapy (ESWT) is indicated for intractable skin wounds and skin ulcers; however, assessing its efficacy for wounds at the periphery of the extremities may be difficult depending on the wound size (small wounds are challenging to differentiate over time with existing scores) and due to unclear metrics for assessing the amount of exudate and inflammation. To overcome this issue, we developed the Hand and Foot Wound Assessment Tool (HFWAT), comprising area and size, necrotic tissue and healthy granulation tissue, depth, amount of exudate, and inflammation and signs of infection. This study aimed to examine the effect of ESWT on obliterating limb wounds and evaluate outcomes using the HFWAT.Methods: The study included seven patients (four males, three females; 63.4±14.0 years) who visited our hospital between April 2018 and March 2020 and presented with persistent skin wounds on the hands and feet that did not heal despite treatment for more than 2 weeks. Patients received an energy flux density of 0.01 mJ/mm2, which was gradually increased. The HFWAT was used to evaluate the wound, and the pre- and post-ESWT scores were compared.Results: Successful wound healing was observed in all patients following ESWT. The median HFWAT score improved from 9.0 (interquartile range, 9–10) points before ESWT to 0.0 (interquartile range, 0–0) points at the final evaluation (P=0.05, n=7).Conclusion: ESWT was effective for intractable wounds, as demonstrated by the significantly improved HFWAT score. Furthermore, the HFWAT could be valuable for assessing small wounds in the peripheral extremities.
Generating Tiny Deep Neural Networks for ECG Classification on Micro-Controllers (2023)

Artificial Intelligence (AI) enabledembedded devices are becoming increasingly important in the field of healthcarewhere such devices are utilized to assist physicians, clinicians, and surgeonsin their diagnosis, therapy planning, and rehabilitation. In current practice,designing such models requires experts in DNN design, healthcare, and embeddedsystems. Additionally, the task of migrating such models to a differentmicrocontroller (MCU) platform typically requires significant effort to re-sizeand/or re-train the model. This paper shows that Neural Architecture Search(NAS) can be used to generate tiny but accurate multi-objective models forclassifying ECG signals. To the best of our knowledge, our framework is thefirst of its kind, for automatically generating a DNN for screening AtrialFibrillation on an MCU. Moreover, our research shows that the proposed NASfinds more accurate tiny models than human-designed ones, and is effective inenabling customized solutions for a resource-limited target platform.
A NONLINEAR MODEL FOR VELOCITY ESTIMATION FROM INFRARED IMAGE SEQUENCES (2010)

Velocity estimation using tracer conservation or heat flow equation based on infrared image sequence is one of the most challenging inverse problems in geosciences and remote sensing applications. In this paper, a new nonlinear model has been created for estimating top surface velocity from an infrared image sequence. The differential form of tracer conservation or heat flow equation is replaced by a temporal integral form of the heat flow conservative constraint equation in which the initial and final states of flow terms are associated with only two time-varying frames at time t 1 and t 2. Iterative equations with Gauss-Newton and Levenberg-Marguardt algorithms for the estimation of the top surface velocity are formulated based on the temporal integral form of the heat flow equation, modelling the velocity field, and a nonlinear least-squares model. The solution of a numerical model is used as a benchmark to exam the new estimator. Both angular and magnitude error measurements based on the synthetic surface heat flow from the numerical model demonstrate that the performance of the new approach with the nonlinear model are much better than the results of using a linear model of the tracer conservation or heat flow equation. One sequence of NOAA AVHRR images taken in the New York Bight fields is also used to demonstrate the performance of the nonlinear inverse model. 1.
End-to-end IP multicast for software upgrades of reconfigurable user terminals within IMT-2000/UMTS networks (2003)

The paper proposes a viable technique for performing software upgrades of reconfigurable user terminals across the entire public land mobile network (PLMN) of an IMT-2000/UMTS network. The proposed solution utilizes over-the-air software downloads in conjunction with IP multicast as the enabling technology. The paper describes in detail the interaction required between logical network elements within the PLMN in order to perform the software upgrade on a set of targeted terminals. The limitations of the proposed technique are outlined and the paper addresses possible schemes for facilitating the presented solution and improving its scalability to large networks.
Rapid Strengthening of Full-Sized Concrete Beams with Powder-Actuated fastening Systems and Fiber-Reinforced Polymer (FRP) Composite Materials (2002)

A research study was conducted to determine if the method of retrofitting reinforced concrete beams with powder-actuated fasteners and composite materials was applicable to full-scale flexural members. The work was conducted in the third year of an ongoing study. This report details the experimental and analytical work completed during the course of a 12 months investigation at the University of Wisconsin-Madison and a 1 month period of experimental testing at the United States Army Research and Development Center (ERDC), Vicksburg, Mississippi. The primary objective of the study was to determine the applicability of the strengthening method to full-scale concrete T-beams similar to those found on bridges within the continental United States. Secondary objectives include expanding the current analytical model, investigating the effects of span ratios, investigating the effects of termination lengths, and studying retrofitted beam behavior under fatigue loading. Nine full-scale T-beams were cast and tested at the ERDC. The results of these tests were analyzed and compared to the expanded analytical model. The test results compared favorably to the analytical predictions. Ten large-scale beams were cast and tested at the University of Wisconsin-Madison, Structures and Materials Testing Laboratory, to investigate the secondary objectives of the study. Overall, the research study showed that the strengthening method is applicable to full-scale T-beams; the strengthening effect is comparable to traditional bonded methods; termination length impacts the failure mode of the strengthened beam; the method can be applied to members with short shear spans; and cyclic loading does not degrade the strengthening system.