gebhart/patrepeval huggingface dataset:
Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTs (2017)

Abstract We previously reported that cooperative RAS-MET signaling drives disease progression in NF1-related MPNSTs, and that MET inhibition results in downstream inhibition of RAS/MAPK in the context of MET amplification. This study revealed that response to MET inhibition appeared to be modulated by P53 gene status. It is currently unclear how P53 function affects kinome signaling and response to kinase inhibition. Here we utilized genetically engineered mouse models with variable levels of Met and Hgf amplification and differential p53 status ( NF1 fl/KO ;lox-stop-loxMET tg/+ ;Plp-creERT tg/+ ; NF1 +/KO ;p53 R172H ;Plp-creERT tg/+ ; and NF1 +/KO ;Plp-creERT tg/+t ). These NF1-MPNST models were used to assess a novel MET/MEK (i.e. RAS-MET) inhibition strategy and investigate the adaptive kinome response to MET and MEK inhibition. We demonstrate that combination MET (capmatinib) and MEK (trametinib) inhibition fully suppresses MET, RAS/MAPK, and PI3K/AKT activation in P53 wild type tumors, whereas P53-mutant tumors demonstrated sustained CRAF, BRAF, and AKT activation in the presence of combined MET and MEK inhibition. Interestingly, trametinib therapy alone strongly activates MET signaling in MET and HGF -amplified tumors regardless of P53 status, an effect that was abrogated by the addition of capmatinib. We conclude that P53 alters RAS-MET signaling interactions that drive therapy resistance in NF1-related MPNSTs.
Airborne Pheromone Quantification in Treated Vineyards with Different Mating Disruption Dispensers against Lobesia botrana (2020)

Mating disruption (MD) is widely used against the European grapevine moth (EGVM), <i>Lobesia botrana</i> (Denis and Schiffermüller; Lepidoptera: Tortricidae), by installing passive dispensers or aerosol devices. The present work reports a new sampling and quantification methodology to obtain absolute data about field airborne pheromone concentration based on air samplings and sensitive chromatographic-spectroscopic methods. Samplings were performed in fields treated with passive dispensers or aerosol devices at different moments throughout the crop cycle to study how they act and how the disruption is triggered. Moreover, pheromone adsorption and releasing capacity of vine leaves were studied to elucidate their role in the disruption. Although both types of dispensers were effective in limiting the damage inflicted by EGVM, they performed differently and provided different airborne pheromone concentration profiles. Results also proved that leaves were able to adsorb and release part of the airborne pheromone acting as subsequent and additional pheromone sources. This fact could explain the different concentration profiles. Moreover, our results suggest that lower pheromone emission than that of the current passive dispensers still could provide an adequate performance in the field. Competitive mechanisms involved in MD using both dispensers, the dynamics of the airborne pheromone throughout the time and the importance of the canopy are discussed.
Automotive displays from direct view to AR head-up (2018)

Advanced displays enable new multimodal interactions for automotive use like (semi-) autonomous driving ranging from direct view to AR head-up displays. This paper presents selected challenges and solution for future automotive applications.
Yeast expression vectors based on pho3 and pho5 promoters of saccharomyces cerevisiae: construction, relative efficiency, use for overproduction of aminoimidazole carboxylase (1988)

Сконструирован ряд дрожжевых векторов экспрессии на основе промоторов РНО3 и РНО5 дрожжей Saccharomyces cerevisiae, отличающихся положением делеции в промоторной области. Два из них испольованы для экспрессии дрожжевого гена ADE2. В результате получены штаммы дрожжей, у которых удельная активность продукта ADE2—фосфорибозиламиноимидазол-карбоксилазы приблизительно в 1000 раз выше, чем у штаммад дикого типа.
A RELAXATION METHOD VIA THE BORN–INFELD SYSTEM (2009)

The semilinear relaxation was introduced by Jin and Xin [Comm. Pure Appl. Math.48, 235, (1995)] in order to approximate the conservation law ∂ t u + ∂ x f(u) = 0 for any flux function f ∈ 𝒞 1 (ℝ;ℝ). In this paper, we propose an alternative relaxation technique for scalar conservation laws of the form ∂ t u + ∂ x u(1 - u)g(u) = 0, where g ∈ 𝒞 1 ([0, 1]; ℝ) and 0 ∉ g(]0, 1[). We extend this new philosophy to an arbitrary flux function f whenever possible. Unlike the semilinear approach, the new relaxation strategy does not involve any tuning parameter, but makes use of the Born–Infeld system. Another advantage of this method is that it enables us to achieve a maximum principle on the velocities w = (1 - u)g and z = -ug, which turns out to be a physically interesting and helpful feature in the context of some two-phase flow problems.
丙戊酸盐和卡马西平诱发的药疹伴嗜酸性粒细胞增多及系统症状：抗190-kDa抗原循环性自身抗体的形成 (2006)

药疹伴嗜酸性粒细胞增多及系统症状（DRESS）的特点是接触特定药物后出现发热、皮疹及内脏器官受累。多数芳香族抗惊厥剂如苯妥英、苯巴比妥及卡马西平可导致DRESS。交叉过敏性可能不仅存在于芳香族抗惊厥剂之间，还存在于芳香族和非芳香族抗惊厥剂之间。作者报道1例韩国女性患者，过去可耐受丙戊酸盐，但服用卡马西平后又因服用丙戊酸盐而诱发DRESS，提示交叉过敏性的可能。患者皮损表现为整个躯体的弥漫性水肿斑及四肢紧张性大疱。间接免疫荧光和免疫印记检测出患者血清存在抗190-kDa抗原循环性自身抗体，其可能是导致DRESS的一个致病因素。
Picojoule-level octave-spanning supercontinuum generation in chalcogenide waveguides (2018)

Low propagation loss Ge<sub>23</sub>Sb<sub>7</sub>S<sub>70</sub> waveguides (0.56 dB/cm) are fabricated in a wafer scale process. Simulation of a 2 cm long, 1.2 μm wide waveguide with 100 ps/nm/km peak dispersion predicts coherent supercontinuum generation at 1.55 μm pump wavelength. Octave-spanning supercontinuum using a dispersive wave is experimentally demonstrated using picojoule-level energy (26 pJ, 240 fs pulse width, 77 W peak power) pulses.
Unlock Mono-Trip Gas Lift Completions Limits by using a New Cement-Through Packer and a Sliding Sleeve with Radio Frequency Identification Capability (2021)

Abstract Gas lift is one of the most appropriate artificial lift methods for Gulf of Thailand (GOT) oil operations. As first described in Chapman, W. R. (2005), Mono-trip gas lift (MTGL) completions have continuously improved since their implementation in the early 2000s, increasing recovery by over 15%. MTGL completions enable marginal or sub-economic new wellhead platforms (WHPs) or infill projects to become economical. To overcome the more challenging wellbore environment in which the current technology is unable to be utilized, alternative technology was trialed in 2019 to enhance the MTGL completion without sacrificing the wellbore designs or reserves.
Docetaxel followed by capecitabine as first-line chemotherapy in metastatic breast cancer patients: Preliminary results (2005)

801 Background: Docetaxel (D) has been concomitantly administered with capecitabine (C) offering clinical benefit to women with metastatic breast cancer (MBC) (ORR: 42%). The aim of this trial was to evaluate the efficacy and tolerance of sequentially administered D plus C as first line treatment in MBC. Methods: Patients ≥ 18 years old with MBC, ECOG performance status (PS) ≤2, HER-2 neu negative, non-chemotherapy naive were included in this prospective, multicentre, non-randomized, phase II study. Three cycles of D (100 mg/m2 d 1) followed by three cycles of C (1250 mg/m2 PO bid d 1–14), were both administered every 3 weeks. Results: To date, 18 patients are evaluable for toxicity and 12 for response. Median age 55 years (36–76); PS 0/1: 59%/41%. All patients had previously received neo/adjuvant anthracyclines treatment, 5 of them concomitant with paclitaxel. The most frequent metastatic sites were: nodes 44%, lung 28% and liver 22%. 72% patients had ≥2 metastatic sites. To date, 18 and 12 patients have received D and C cycles, respectively. A total of 75 cycles have been administered: D 45 cycles (median 3, range 1–3)/ C 30 cycles (median 3, range 1–3). Dose reduction per patient: D 33%/ C 25%. Dose delay per patient: D 17%/ C 17%. Median relative dose intensity: D 0.91 (range: 0.75–1.00), C 0.93 (range: 0.26–1.0). D grade III/IV toxicities: mucositis 4/18 (22%), febrile neutropenia 3/18 (17%), asthenia 3/18 (17%), rash 2/18 (11%), infection 1/18 (6%), diarrhea 1/18 (6%), nausea 1/18 (6%). C grade III toxicities: hand foot syndrome 1/12 (8%), nausea 1/12 (8%), anorexia 1/12 (8%). Three patients have dropped up the study: 1 due to D toxicity and 2 for progressive disease after 2nd C cycle. Three out of 12 patients evaluable for overall response reached a complete clinical response and 4 a partial response with an ORR of 58%. Conclusions: These preliminary results show the efficacy of the sequential treatment of D and C that seems to be comparable to the concomitant administration of both drugs with a better toxicity profile. No significant financial relationships to disclose.
AN OVERVIEW OF @NIX (1982)

@NIX is an automatic programming system being developed for use by petroleum scientists who may not be knowledgable about computers. As a first step, a system has been implemented to assist in the trial-anderror process of developing new models and techniques for quantitative interpretation of well logs. The user interface exploits graphical techniques to enable petroleum scientists to describe their models in the natural concepts of the domain. The resulting specification can be implemented in any of several different target languages. The system is in active use by petroleum scientists, who find that it has significantly reduced the time to get feedback on hypothesized models.
Cerenkov radiation as a source of ultraviolet radiation (1973)

The Cerenkov effect is considered as a source for far and vacuum ultraviolet radiation. Power per unit wavelength compares favorably with synchrotron emission, and the radiation is well collimated and confined to a small solid angle. The absence of spectral lines in the emission provides a source that is useful for certain types of spectroscopic studies.
Applicability of oxygen scavengers for shelf life extension during illuminated storage of cured cooked meat products packaged under modified atmosphere in materials with high and low oxygen permeability (2020)

The aim of this study was to evaluate the effect of illumination, packaging material and application of oxygen scavengers on the shelf life of two different cured cooked meat products in diverse retail storage conditions. For this purpose, ham luncheon sausage and pork liver pâté were packaged in high‐ and low‐OTR (oxygen transmission rate) packages under modified atmosphere. Packages either did or did not contain a 50‐ml O 2 capacity oxygen scavenger. Samples were stored at 7°C either in complete darkness or illuminated by fluorescent or LED lamps for the last 48 h of storage. Microbial quality of pâté was more crucial than that of ham sausage, partially due to a higher initial microbial load. Pâté was far more susceptible to discolouration and lipid oxidation than ham luncheon sausage. Illumination was a crucial aspect for discolouration of ham sausage, whereas pâté exhibited discolouration without illumination when packaged in low barrier packages. Hence, high barrier packages are indispensable for these types of products, especially pâté. Inclusion of an oxygen scavenger may lead to improved colour stability and lower lipid oxidation, provided that the packaging material had a sufficiently low OTR and some days of dark storage preceded illumination. Replacing a multilayered high‐barrier packaging system with a lower barrier system with an added scavenger is not an interesting option as there is competition for oxygen absorption between the food product and the scavenger.
(6S)-2,4-Di-tert-butyl-6-[(4S,5R)-3-isopropyl-4-methyl-5-phenyloxazolidin-2-yl]phenol (2010)

The title oxazolidine compound, C(27)H(39)NO(2), was synthesized from N-isopropyl-norephedrine. The dihedral angle between the aromatic rings is 70.33 (5)°. The N atom of the heterocycle is oriented to allow intra-molecular O-H⋯N hydrogen bonding with the hydr-oxy substituent.
Selling Multiple Correlated Goods: Revenue Maximization and Menu-Size Complexity (old title: "The Menu-Size Complexity of Auctions") (2013)

We consider the well known, and notoriously difficult, problem of a single revenue-maximizing seller selling two or more heterogeneous goods to a single buyer whose private values for the goods are drawn from a (possibly correlated) known distribution, and whose valuation is additive over the goods. We show that when there are two (or more) goods, _simple mechanisms_ -- such as selling the goods separately or as a bundle -- _may yield only a negligible fraction of the optimal revenue_. This resolves the open problem of Briest, Chawla, Kleinberg, and Weinberg (JET 2015) who prove the result for at least three goods in the related setup of a unit-demand buyer. We also introduce the menu size as a simple measure of the complexity of mechanisms, and show that the revenue may increase polynomially with _menu size_ and that no bounded menu size can ensure any positive fraction of the optimal revenue. The menu size also turns out to "pin down" the revenue properties of deterministic mechanisms.
Cost-Based Heuristic Search Is Sensitive to the Ratio of Operator Costs (2021)

In many domains, different actions have different costs. In this paper, we show that various kinds of best-first search algorithms are sensitive to the ratio between the lowest and highest operator costs. First, we take common benchmark domains and show that when we increase the ratio of operator costs, the number of node expansions required to find a solution increases. Second, we provide a theoretical analysis showing one reason this phenomenon occurs. We also discuss additional domain features that can cause this increased difficulty. Third, we show that searching using distance-to-go estimates can significantly ameliorate this problem. Our analysis takes an important step toward understanding algorithm performance in the presence of differing costs. This research direction will likely only grow in importance as heuristic search is deployed to solve real-world problems.
Optical fluorescence excitation spectra of flux-grown stoichiometric europium vanadate crystals (1993)

The intrinsic site optical absorption of EuVO4 from 7F0 to 5D0, 5D1, 5D2, and 5D3 exhibits normal behaviour, but sensitive laser excitation profiles measured in the Eu3+:7F0 to 5D0 region (580 nm) map out more than 40-50 defect lines spread over some 60 cm-1. Each of these must be due to a distinct type of defect site in the crystal structure. A number of different EuVO4 crystals prepared from fluxes with different compositions have been used to show that some of these point defects are associated with specific chemical impurities while others seem to be present even in the purest crystals. Electronic Zeeman shifts of the Eu3+:7F0 to 5D0 optical lines for some of the low-symmetry perturbed sites provide additional information on defect geometry and on the low-lying 7F1 electronic levels for those specific perturbed sites. High degrees of site distortion are indicated for some of the sites, and principal axes are shown to make oblique angles to normal crystal axes.
Changes in Surface Structure during Direct Somatic Embryogenesis in Rice Scutellum Observed by Scanning Electron Microscopy (1998)

Direct somatic embryogenesis in rice scutella was studied by scanning electron microscopy paying attention to the morphological change of surface structure. Somatic embryos were formed when the scutella of immature embryos of cv. Nipponbare were cultured on MS media containing 2 mg L−1 2,4-D. Embryos were then transferred to the media containing 1 mg L−1 2,4-D and germinated on hormone-free media. The developmental stages of typical monocotyledonous somatic embryo were classified into proembryo, globular, scutellar and coleoptilar stages by referring to the terminology used for zygotic embryos. Each stage had a characteristic surface structure. The surface of proembryo was smooth. Fibrillar material was observed during the transition from proembryo to globular stage. Fibrillar material was then gradually replaced by a mesh-like structure at the globular stage. With subsequent development of globular embryo, the apical scutellum region became flattened and the ridge of mesh-like structure became lower. Development of scutellum followed by the emergence of coleoptile from the scutellar notch was observed at the scutellar stage. The coleoptile surface was covered with elongating cells. The coleoptilar stage was characterized by the growth of coleoptile and the development of root. However, aberrant somatic embryos which had leafy scutellum and multiple shoot meristem, were also observed.
Změny systolické funkce levé komory hodnocené pomocí tkáňového dopplerovského zobrazení u nemocných s chronickou ischemickou chorobou srdeční a pravidelnou fyzickou aktivitou (2005)

Pomoci TDI lze hodnotit změny systolicke funkce LK v klidu i při zatěži u nemocných s chronickou ICHS. U nemocných s pravidelnou 12 měsicni fyzickou aerobni aktivitou se zlepsila celkova i regionalni systolicka funkce LK.
Organocatalyzed Conjugate Umpolung of α,β‐Unsaturated Aldehydes for the Synthesis of γ‐Butyrolactones (2004)

Advantage organocatalysis: N-heterocyclic carbenes can generate homoenolate equivalents under mild conditions by conjugate umpolung of α,β-unsaturated aldehydes. This organocatalytic reaction allows an efficient one-step synthesis of substituted γ-butyrolactones 1 (see scheme, Mes=mesityl). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z461572_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A new species ofPoroconiochaetafrom Russian soils (2003)

Poroconiochaeta tetraspora sp. nov., isolated from soil of Russia, is described and illustrated. The new taxon differs from P. discoidea in its four-spored asci (eight-spored in P. discoidea) and from P. punctulata in the pattern of ascospore ornamentation, which is conspicuously pitted in P. tetraspora (punctulate in the other species). The new combination Poroconiochaeta savoryi is proposed and discussed.
Laser-induced structural instabilities in amorphous materials (1987)

Amorphous materials irradiated by cw lasers undergo structural changes, which depend quasiperiodically on the irradiation time. The changes in the transmitted light intensity are related to the changes of the Raman line shape. The structural changes between metastable states are favored by the photogenerated free carriers.
Changes of Functional and Effective Connectivity in Smoking Replenishment on Deprived Heavy Smokers: A Resting-State fMRI Study (2013)

Previous researches have explored the changes of functional connectivity caused by smoking with the aid of fMRI. This study considers not only functional connectivity but also effective connectivity regarding both brain networks and brain regions by using a novel analysis framework that combines independent component analysis (ICA) and Granger causality analysis (GCA). We conducted a resting-state fMRI experiment in which twenty-one heavy smokers were scanned in two sessions of different conditions: smoking abstinence followed by smoking satiety. In our framework, group ICA was firstly adopted to obtain the spatial patterns of the default-mode network (DMN), executive-control network (ECN), and salience network (SN). Their associated time courses were analyzed using GCA, showing that the effective connectivity from SN to DMN was reduced and that from ECN/DMN to SN was enhanced after smoking replenishment. A paired t-test on ICA spatial patterns revealed functional connectivity variation in regions such as the insula, parahippocampus, precuneus, anterior cingulate cortex, supplementary motor area, and ventromedial/dorsolateral prefrontal cortex. These regions were later selected as the regions of interest (ROIs), and their effective connectivity was investigated subsequently using GCA. In smoking abstinence, the insula showed the increased effective connectivity with the other ROIs; while in smoking satiety, the parahippocampus had the enhanced inter-area effective connectivity. These results demonstrate our hypothesis that for deprived heavy smokers, smoking replenishment takes effect on both functional and effective connectivity. Moreover, our analysis framework could be applied in a range of neuroscience studies.
Diastereoselective Reduction of Alkenylboronic Esters as a New Method for Controlling the Stereochemistry of up to Three Adjacent Centers in Cyclic and Acyclic Molecules (2002)

[reaction: see text] cis-Boronates are readily available via a diastereoselective Pd-catalyzed reduction of tetrasubstituted alkenylboronic esters using H2. Applying the reaction conditions presented to unsaturated open-chain boronic esters allows the stereochemistry of up to three adjacent centers to be controlled.
Photonic effects in microstructured conjugated polymer films and light emitting diodes (2002)

This thesis reports an investigation into the photonic effects caused by wavelength scale microstructure patterned onto films of conjugated polymers. The efficiency of light emitting diodes (LEDs) made from conjugated polymers is limited in part by the trapping of light into waveguide modes caused by the high refractive index of these materials. Waveguide modes in films of poly(p,-phenylene vinylene) (PPV) and poly(2-methoxy, 5-(2'ethylhexyloxy)-p-phenylene vinylene) (MEH-PPV) are analysed and the refractive index of these materials is calculated. The photoluminescence of conjugated polymer films that have been spun onto textured substrates is analysed. It is found that the photoluminescence quantum yield of a film spun onto a substrate inscribed with a grating is increased. It is also found that the photoluminescence spectrum of the film is dramatically altered and varies substantially with viewing angle. The features in the spectrum caused by the grating are strongly polarized. These effects are analysed and are attributed to the scattering of waveguided light out of the film. It is found that films spun onto metal gratings exhibit especially strong scattering. The effect of metal gratings with various grating depths is analysed. The possible contribution of band gaps to the photoluminescence spectrum from polymers on strong metal gratings is discussed. LEDs that include grating structures are constructed and analysed. It is found that having grating structures on the metal layers that are used as electrodes in the LED does not adversely affect the electrical properties of the LED. It is demonstrated that grating in the LED is able to substantially increase the light emission without using extra electrical power. The emission spectra from LEDs are observed to vary with angle, and exhibit considerable polarization. (author)
Study on a fast controlled partition scheme based on improved Dinic max-flow strategy (2015)

When power system is subjected to severe disturbances and then will be out of step. The interconnected power grid should be split into several islands to avoid blackout. The controlled islanding is an active control technique based on the information from Wide Area Measurement System (WAMS) to accomplish the islanding task. This paper proposes a fast islanding strategy for large power networks. Firstly, the grid structure is mapped to point sets and edge sets in the graph theory. Secondly, the model is built by adopting the minimum power flow impact as the objective function and considering several constraints which includes generator coherency constraint and connective constraint. Finally, the optimal splitting strategy is searched by the improved Dinic maximum flow algorithm. Simulation results on IEEE 118-bus power system show that the proposed strategy is correct, effective and fast.
“One size fits all” database architectures do not work for DSS (1995)

No abstract available.