gebhart/patrepeval huggingface dataset:
[Pravastatin in the treatment of primary hypercholesterolemia: a Swiss multicenter study]. (1993)

Conventional lipid-lowering agents displayed only limited efficacy in lowering total and LDL cholesterol and a high incidence of side effects. Pravastatin is a new potent cholesterol-lowering agent, which selectively inhibits hepatic HMG-CoA-reductase. In a double-blind, placebo-controlled Swiss multicenter study with determination of lipids and lipoprotein in a central laboratory, the efficacy and safety of 6 months' therapy with pravastatin was evaluated in 50 patients with mild hypercholesterolemia and additional coronary risk factors. Compared to baseline and after 26 weeks' therapy, pravastatin significantly reduced total cholesterol (pravastatin vs placebo, -17% vs +7%, p < 0.0001) and LDL cholesterol (-26 vs +2%, p < 0.0001). The total/HDL cholesterol ratio ( = "atherogenic index") was comparable in the two groups at baseline (5.9 +/- 1.1 vs 6.3 +/- 0.9), and was distinctly lowered by pravastatin but not placebo (-20 vs 0%, p < 0.0001). In 11 patients in whom the reduction of serum total cholesterol after 13 weeks' treatment with 20 mg pravastatin was still below target (on average -9.1%), doubling of the dose produced a further decrease of 4.3%. Serum HDL cholesterol and serum triglyceride levels did not change significantly during pravastatin treatment as compared to baseline and placebo. Pravastatin was well tolerated during the 26 weeks without relevant subjective side-effects. There were 5 dropouts during the study, 2 patients in the pravastatin group and 3 in the placebo group. These findings document that pravastatin, administered in a single daily dose of 20 to 40 mg, effectively lowers serum cholesterol and total-/HDL-cholesterol improving action and is well tolerated.
ChemInform Abstract: HEXARADIALENE (1978)

Abstract Die Pyrolyse des Triins (I) bei 850°C und l0′3 Torr zeigt beim Auffangen des Pyrolysats bei ‐196°C NMR‐spektroskopisch die Bildung eines Produktes mit olefinischen Bindungen.
Use of health care services and pharmaceutical agents in coeliac disease: a prospective nationwide study (2012)

ClinicalTrials.gov NCT01145287.
Adaptive Fuel Control Feasibility Investigation for Helicopter Applications (1982)

A United States Army-sponsored, computer-aided study of a twin engine helicopter is being conducted to determine the feasibility of incorporating into the engine microprocessor-based control system, airframe signals and control strategies that improve helicopter capability. Investigations are considering on-line changes to the control characteristics which adapt to abnormal engine operation due, for example, to engine deterioration, surge or failure. The anticipation of power recovery from a split needle condition is accomplished with rotor speed feedback which allows increased transient load factors and improved handling qualities in maneuvering flight. For minimum fuel consumption in cruise, the control will seek the optimum rotor speed. An improvement in torsional damping is achieved with software filters which reduce the dependability of the drive train stability on the blade lag dampers. Studies to date indicate that there may be substantial payback in implementing these new control features.
Numerical investigations on the influence of the weld surface and die geometry on the resulting tensile stresses in the joining zone during an extrusion process (2021)

Bulk metal components are often used in areas which are subjected to very high loads. For most technical components, a distinction between structural and functional areas can be made. These areas usually have very different loading profiles, sometimes with contradictory requirements. Nevertheless, nowadays almost only monomaterials are used for the production of bulk metal components. With increasing requirements towards more and more efficient products with lower weight, compact design and extended functionality, these materials are reaching their material-specific limits. A significant increase of product quality and economic efficiency can be expected exclusively with locally adapted properties by combining different materials within one component. In this regard, the focus of this contribution is the production of a hybrid pinion shaft made of the material combination steel (37CrS4) and aluminium (AW6082). The tool concept for extrusion of the hybrid preform, the simulation-based design of the forming process as well as the material characterisation are presented. With the help of the FE-simulation, different serially arranged semi-finished component geometries were investigated in order to minimise the occurring tensile stresses in the component during the extrusion process to prevent failure during forming.
Turkey Behavior Identification Using Video Analytics And Object Tracking (2021)

In this paper, we propose a method to identify behavior of experimental turkeys by automatically analyzing video recordings. Monitoring turkey health during production is crucial for improved turkey production. Turkey health can be reflected through their common behavior, and changes in the frequency and duration of their behavior can be used to detect sick turkeys early. Video recordings can be manually annotated to assist identifying turkey behaviors, but this is both time consuming and labor intensive. In this paper, we monitor and detect changes in turkey behavior using video analytics. Behaviors of interest include eating, drinking, preening, and pecking. Identifying these behaviors requires accurate estimates of turkeys’ and turkey heads’ locations. Re-identification of each turkey is crucial after significant shape deformation such as wing flapping and fast walking. Therefore, our system integrates a state-of-the-art turkey tracker and a head tracker with a behavior identification module to identify turkey behavior. Results demonstrate that our system is effective and accurate at estimating the spatial location of turkeys and their heads, and identifying all behaviors of interest with high recall.
OWL-SF - A Distributed Semantic Service Framework (2005)

S.67-78
Real-time 2D Multi-Person Pose Estimation on CPU: Lightweight OpenPose (2019)

In this work we adapt multi-person pose estimation architecture to use it on edge devices. We follow the bottom-up approach from OpenPose, the winner of COCO 2016 Keypoints Challenge, because of its decent quality and robustness to number of people inside the frame. With proposed network design and optimized post-processing code the full solution runs at 28 frames per second (fps) on Intel$\unicode{xAE}$ NUC 6i7KYB mini PC and 26 fps on Core$^{TM}$ i7-6850K CPU. The network model has 4.1M parameters and 9 billions floating-point operations (GFLOPs) complexity, which is just ~15% of the baseline 2-stage OpenPose with almost the same quality. The code and model are available as a part of Intel$\unicode{xAE}$ OpenVINO$^{TM}$ Toolkit.
Concurrent dual‐band GaN power amplifier with compact microstrip matching network (2009)

Abstract A concurrent dual‐band power amplifier (PA) using circuit transformations in the design of the dual‐band matching networks (MN) are outlined and a transmission line compression technique is used reduce the insertion loss of the MNs. A 10‐W Gallium Nitride based PA operating concurrently at 2.5 GHz and 3.5 GHz is compared with the performance of the equivalent single‐band PAs. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1604–1607, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24380
Improving the radiation characteristics of shorted annular ring antennas through symmetric aperture-coupled feeding (2023)

In this paper, a novel feeding method for shorted annular ring (SAR) antennas is presented. SAR antennas can be designed to not excite surface waves and hence have desirable properties for many applications. The traditional method of feeding a SAR is through a single probe. Using two probes i.e. a differential feeding method, the current distribution and hence the pattern become more symmetric. However, steep current gradients on the patch make it difficult to obtain a robust design against manufacturing tolerances. A novel feeding method based on a dual aperture coupling approach is proposed to overcome the limitations of a dual-probe feeding approach while still maintaining the reduced surface wave characteristics. Additionally, this feeding method is shown to provide an increase in broadside gain of almost 3dB through eliminating disturbances in the current density on the SAR.
Subjective tinnitus assessment and treatment in clinical practice (2015)

Every patient with subjective tinnitus has its unique 'tinnitus profile' which provides a guide to the necessary combination of therapeutic actions. Evidence suggests the multidisciplinary approach combining etiological therapy as well as TRT, and cognitive behavioral therapy in specialized clinics is not only effective in reducing the patient's quality of life but also cost-effective from a healthcare and societal point of view.
Modeling the Water Barrier Properties of Nylon Film Intended for Food Packaging Applications (2003)

ABSTRACT: This paper presents a mathematical model able to predict the water barrier properties of nylon film as a function of the water activity at the upstream and downstream side of the film. To validate the model, water sorption and permeation tests were conducted at 25 °C. The fitting and predictive ability of the proposed model was successfully tested by fitting the model to the sorption data and by predicting the nylon water permeability coefficient, respectively. The implications of the adopted approach on practical aspects of packaging were pointed out by comparing the nylon water barrier properties as evaluated by means of a permeation test and that in the real working conditions.
Generalized Multi-Protocol Label Switching (GMPLS) Signaling Resource ReserVation Protocol-Traffic Engineering (RSVP-TE) Extensions (2003)

This document describes extensions to Multi-Protocol Label Switching (MPLS) Resource ReserVation Protocol - Traffic Engineering (RSVP-TE) signaling required to support Generalized MPLS. Generalized MPLS extends the MPLS control plane to encompass time-division (e.g., Synchronous Optical Network and Synchronous Digital Hierarchy, SONET/SDH), wavelength (optical lambdas) and spatial switching (e.g., incoming port or fiber to outgoing port or fiber). This document presents a RSVP-TE specific description of the extensions. A generic functional description can be found in separate documents.
Complete assignments of magnetic resonances of ribonuclease H from Escherichia coli by double- and triple-resonance 2D and 3D NMR spectroscopies (1993)

Assignments of 1H, 15N, and 13C magnetic resonances for ribonuclease H from Escherichia coli have been completed using double- and triple-resonance 2D and 3D NMR experiments. These assignments include all types of 1H, 15N, and 13C nuclei detectable by NMR. The enzyme used, which cleaves the RNA moiety of an RNA-DNA duplex, consists of 155 amino acid residues and has 1962 nuclei (227 nitrogen, 762 carbons, and 973 protons) observable independently by NMR. Among those, 1868 nuclei (95%) have been assigned. Two methods, 3D HCH and 13C-13C-1H heteroSQC/homoSQC, were newly devised to complete the side chain assignments. These methods were used to elucidate the -CH2- and -C-CH-substructures. Triple-resonance experiments to detect other types of substructures, (e.g., -N-CH- and -C-NH-) were also applied. In total, 10 kinds of 3D NMR experiments were used to complete the assignments. The chemical shifts obtained through the assignments were analyzed in terms of the tertiary structure of the protein molecule. Among the 13C chemical shifts, larger secondary shifts (deviations from shifts at the random coil state) were observed for the C alpha, C beta, and C' nuclei, which reflect the local structures on the backbone, that is, the alpha-helix, beta-sheet, and left-handed helix, respectively.
Stereospecific Activation of the Procarcinogen Benzo[a]pyrene: A Probe for the Active Sites of the Cytochrome P450 Superfamily (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific Activation of the Procarcinogen Benzo[a]pyrene: A Probe for the Active Sites of the Cytochrome P450 SuperfamilyJeffrey P. Jones, Magang Shou, and Kenneth R. KorzekwaCite this: Biochemistry 1995, 34, 21, 6956–6961Publication Date (Print):May 30, 1995Publication History Published online1 May 2002Published inissue 30 May 1995https://doi.org/10.1021/bi00021a007RIGHTS & PERMISSIONSArticle Views73Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Fast carry free adder design using QSD number system (2002)

A high speed parallel full adder is designed which can perform carry-free addition of two modified signed digit quaternary numbers. For digital implementation, the sign digit quaternary numbers are represented using 3-bit 2's complement notation. The adder truth table with possible schemes of the electronic and optical implementation are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tetanus Toxin and Antigenic Derivatives II. Effect of Protein and Formaldehyde Concentration on Toxoid Formation (1967)

Tetanus toxoid formation was examined under varying conditions. Products of the reaction depended upon the concentration of both formaldehyde and toxin. High concentrations of protein and formaldehyde favored the formation of large polymers, whereas low concentrations yielded smaller polymers and monomer. The monomer had an observed S value of 7.1, whereas the polymers ranged from 10.1S to 110S. The cross-linking between toxin molecules to form toxoid polymers appeared to be random.
Apomixis and Heterosis (1999)

Apomixis is in the early stages of making a contribution to crop improvement. Bashaw and Hussey reported on the use of apomixis to produce apomictic forage hybrids in Cenchrus by traditional crossing methods. Apomixis has the most immediate potential to improve production in crops where efficient systems for producing hybrids are not available. Facultative apomixis can be effectively used to fix various levels of heterosis when complete genetic homogeneity and morphological uniformity are not necessary. This chapter elaborates on the use of apomixis to increase crop production in developing countries. It is well documented that use of hybrid vigor is an effective way to maximize production; however, one of the arguments for not using hybrids in developing countries is that they reduce the genetic diversity in farmers' fields, which increases the vulnerability to changes in environmental conditions.
Tissue reduction of map numbers after post-exposure vaccination with single latency antigen is improved by combination with acute-stage antigens in goats (2014)

A new (FET11) multi-stage vaccine against paratuberculosis has been shown to reduce Map numbers in cattle after post-exposure vaccination. Here we investigated the effect of vaccination with latency antigen alone, or two different constructs of the multi-stage vaccine in a goat model. Goats were orally inoculated with 4x10E9 live Map in their third week of life and randomly assigned to four groups of five goats each. One group was left unvaccinated, while other goats were post-exposure vaccinated at 14 and 18 weeks post Map inoculation with either a single FadE5 protein (100 μg), FET11 multi-stage vaccine with FadE5 (60 μg) and ESAT-fusion protein (40 μg), or FET13 with FadE5 and ESAT proteins combined in a single fusion protein (100 μg), respectively. All proteins were delivered in CAF09 adjuvant (DDA/MMG/Poly I:C). Antibody responses were measured by ID Screen® ELISA and individual vaccine protein ELISAs along with IFN-γ release assay with PPDj and vaccine proteins. At termination 32 weeks post Map inoculation, Map burden in 15 gut tissues and lymph nodes was determined by quantitative IS900 PCR. FadE5 vaccination induced a protective effect in goats with consistently reduced Map numbers compared to unvaccinated control goats. FET11 and FET13 vaccination, however, provided significantly protection with absent or very low Map numbers in tissues. No goats seroconverted in ID Screen® ELISA, except for a single goat in the unvaccinated control group at last sampling prior to euthanasia. PPDj responses were low in all goats at all times. These results indicate a combination of acute and latent stage antigens in appropriate adjuvant formulation induces a protective immune response against paratuberculosis and corroborate previous findings of the FET11 vaccine in calves.
Arrêté concernant les examens d'aptitude concernant les examens d'aptitude aux bourses de l'Etat et le régime des boursiers dans les écoles primaires supérieures (1882)

Bert Paul. Arrêté concernant les examens d'aptitude concernant les examens d'aptitude aux bourses de l'Etat et le régime des boursiers dans les écoles primaires supérieures. In: Bulletin administratif de l'instruction publique. Tome 25 n°474, 1882. pp. 13-19.
Structural Charactrization of Oils from Coal Liquids by HPLC-MS Spectroscopy (1983)

n-Hexane soluble oils from hydrogenolysis of three different coals (Tenppoku coal (C: 72. 7‰); Miike coal (C: 84. 5‰) and Illinois No.6 coal (78. 7‰)) were investigated aimed to the characterization of chemical structure and its relation to the coal rank. These oils were separated into compound classes designated by Fr-P, -M, -D and-T which consisted mainly of paraffin, monoaromatics, diaromatics and tri-and tetraaromatics, respectively. The separation was carried out by means of high pressure liquid chromatography (HPLC) using a μ-Bondapak-NH2 packed column.Fr-P was analysed by GC-MS. The ionization voltage of the MS was of 20 eV. Characteristic patterns of total ion chromatogram indicating existence of n-paraffine from C14 to C28 or C30, were observed for the three coals. Mass spectra of compounds from individual chromatogram peaks had also specific fragmentation profiles of n-paraffines.To the aromatic fractions, Fr-M, -D and-T, low voltage mass spectra were measured and the chemical structure was elucidated as compound types as indicated by the Z values and their corresponding molecular weight distributions. From these results, the influence of the degree of coal rank in the chemical structure of the aromatic oils can be summarized as follows:1) Species of compound types were the same regardless the different ranks of coals.2) Relative contents of aromatic types in fractions were different with rank of parent coal. The oil from Tenppoku coal, belonging to a low rank coal, had less number of naphthenic rings attached to monoaromatic compounds. On the comparison of the Z series distribution for Fr-T of oils from the three different coals, it can be observed that there is a shift to lower ring number for the oil from Tenppoku coal. On the other hand, the high rank coal, Miike coal, had larger naphthenic monoaromatic type and larger aromatic ring compounds in Fr-T.3) Distribution of alkyl groups substituted to aromatic and hydroaromatic rings varied with the rank of coal. For Tenppoku coal, large alkyl structures to monoaromatics were observed while less alkyl structure substituted to tri-and tetraaromatic is predominating in the higher rank coal, Miike coal.As shown before, HPLC-MS procedure is a useful method for the routine character-ization of the chemical structure of oils from coal liquids.
Ultra-Low Power Consuming Direct Radiation Sensors Based on Floating Gate Structures (2017)

In this paper, we report on ultra-low power consuming single poly floating gate direct radiation sensors. The developed devices are intended for total ionizing dose (TID) measurements and fabricated in a standard CMOS process flow. Sensor design and operation is discussed in detail. Original array sensors were suggested and fabricated that allowed high statistical significance of the radiation measurements and radiation imaging functions. Single sensors and array sensors were analyzed in combination with the specially developed test structures. This allowed insight into the physics of sensor operations and exclusion of the phenomena related to material degradation under irradiation in the interpretation of the measurement results. Response of the developed sensors to various sources of ionizing radiation (Gamma, X-ray, UV, energetic ions) was investigated. The optimal design of sensor for implementation in dosimetry systems was suggested. The roadmap for future improvement of sensor performance is suggested.
A Case of Mediastinal Pancreatic Pseudocyst (2002)

Background: A pancreatic pseudocyst is one of various complications occurring in acute of chronic pancreatitis. It is usually located in the retroperitoneal space near the pancreas. However, other unusual locations are also possible. Jones intially described the mediastinal pseudocyst in 1940. Since then, fewer than 50 cases have been reported. A diagnosis of a mediastinal pseudocyst is accomplished by imaging studies revealing the cystic nature of the mass with evidences of acute or chronic pancreatitis. There is some controversy regarding the appropriate management of mediastinal pseudocyst because of the high mortality and morbidity after surgical management.Here we report a case of a mediastinal pancreatic pseudocyst found in a patient with asymptomatic alcohol-related pancreatitis complicated by the development of a mediastinal peudocyst, which quickly resolved after endoscopic retrograde pancreatic and biliary drainage and subcutaneous injection of a somatostatin analog(octreotide acetate) without any complications.
Mediating awareness and communication through digital but physical surrogates (1999)

Digital but physical surrogates are tangible representations of remote people positioned within an office and under digital control. Surrogates selectively collect and present awareness information about the people they represent. By having them react to physical actions of people, surrogates can control the communication capabilities of a media space. This enables the smooth transition from awareness to casual interaction while mitigating concerns about privacy.
Network Virtualization: Technologies, Perspectives, and Frontiers (2012)

Network virtualization refers to a broad set of technologies. Commercial solutions have been offered by the industry for years, while more recently the academic community has emphasized virtualization as an enabler for network architecture research, deployment, and experimentation. We review the entire spectrum of relevant approaches with the goal of identifying the underlying commonalities. We offer a unifying definition of the term “network virtualization” and examine existing approaches to bring out this unifying perspective. We also discuss a set of challenges and research directions that we expect to come to the forefront as network virtualization technologies proliferate.