gebhart/patrepeval huggingface dataset:
An overview of in-flight plume diagnostics for rocket engines (1992)

An overview and progress report of the work performed or sponsored by LeRC toward the development of in-flight plume spectroscopy technology for health and performance monitoring of liquid propellant rocket engines are presented. The primary objective of this effort is to develop technology that can be utilized on any flight engine. This technology will be validated by a hardware demonstration of a system capable of being retrofitted onto the Space Shuttle Main Engines for spectroscopic measurements during flight. The philosophy on system definition and status on the development of instrumentation, optics, and signal processing with respect to implementation on a flight engine are discussed.
Requirements of e-beam size and position accuracy for photomask of sub-32 nm HP device (2010)

As semiconductor features shrink in size and pitch, there are strong needs for an advanced mask writer which has better patterning quality. Among various requirements for next photomask writer, we have focused on the requirements of ebeam size and position accuracy for hp 32nm and beyond generation. At the era of DPT, EUV, and complex OPC, the photomask is required to have extreme control of critical dimension (CD). Based on simulation and experiment, we present the e-beam requirements for advanced mask writer, in view point of stability and accuracy. In detail, the control of e-beam size in mask writer should be decreased to 0.5nm because the size error of e-beam gives rise to large CD error according to the high complexity of mask pattern. Furthermore, the drift error of beam position should be smaller than 1nm to obtain the tight pattern placement error and to minimize the edge roughness of mask pattern for the era of computational lithography and EUV lithography.
Diagnostic potential of peri‐implant crevicular fluid microRNA‐21‐3p and microRNA‐150‐5p and extracellular vesicles in peri‐implant diseases (2020)

An increase concentration of EVs with a downregulation expression of miRNA-21-3p and miRNA-150-5p could be related with the peri-implantitis development.
Cathepsin D and Prognosis in Breast Cancer (1990)

We investigated the possibility that cathepsin D, an estrogen-induced lysosomal protease, might have value as a prognostic factor in breast cancer by studying frozen tissue specimens from 397 patients. We measured the 34-kd mature form of the enzyme by Western blot assay and densitometry. Among 199 patients with node-negative disease, but not among 198 with node-positive disease, high levels of cathepsin D proved to be a significant predictor of reduced disease-free survival (median follow-up, 64 months), either as a continuous variable (log cathepsin D; P = 0.018) or as a dichotomous variable with an optimized cutoff point (P = 0.0001). Results were similar for overall survival (P = 0.009 and 0.0001, respectively). Relating the level of cathepsin D to other prognostic factors in the patients with node-negative disease, we found an association with aneuploidy but none with estrogen or progesterone receptors, tumor size, or the age of the patient. In multivariate analyses, a high level of cathepsin D was the most important independent factor in predicting shorter disease-free and overall survival in patients with node-negative disease. As compared with the risk in women with low levels of cathepsin D, the relative risk of tumor recurrence was 2.6 (95 percent confidence interval, 1.6 to 4.4) and the relative risk of death was 3.9 (95 percent confidence interval, 2.1 to 7.3) among those with high levels of cathepsin D. For disease-free survival, cathepsin D status was predictive of outcome primarily among those with aneuploid tumors; the actuarial five-year recurrence rates of aneuploid tumors were 60 percent among women with high levels of cathepsin D and 29 percent among those with low levels, as compared with 22 percent for all diploid tumors. We conclude that cathepsin D may be an independent predictor of early recurrence and death in node-negative breast cancer.
Techniques of Programming (2000)

This chapter provides answers to a host of everyday questions about programming: How do I access tables, cells, and regions of cells? How do I carry out calculations with dates and times? How are character strings processed? How are new worksheet functions defined?
New Bit Design, Cutter Technology Extend PDC Applications to Hard Rock Drilling (2005)

Abstract An advanced series of PDC drill bits incorporating a new highly abrasion-resistant PDC cutter has extended effective PDC bit application to hard rock drilling. In direct offset comparisons, the advanced series of PDC bits fitted with the new cutters delivered significant increases in footage drilled and rate of penetration. To achieve an optimum match in drilling efficiency and bit life to lower costs and mitigate risk in hard rock environments, the series is designed using a combination of advanced modeling capabilities and sophisticated analytical tools. These tools allow the designs to be "customized" for specific applications, optimizing cutting efficiency and durability according to specific rock properties and drilling parameters. A transitional drilling model simulation allows evaluation of how cutting forces are affected during transitional drilling, common in "hard rock" environments. The bit design is globally balanced to optimize axial, lateral, and torsional forces, and can be modified by adjusting features such as profile shape, cutter rake angles, impact arrestors, and cutter type, to optimize bit performance when drilling in hard and transitional environments. In addition, recognition of a third dimension of PDC performance – Thermal Mechanical Integrity (TMI) -- has lead to development of a new PDC cutter that provides 13.5 times the abrasion resistance of the industry standard, without sacrificing impact resistance. This improved understanding of PDC cutter failure provides a different way of looking at the traditional characteristics of abrasion and impact, enabling cutter durability to be optimized in both abrasive and hard, inter-bedded formations. The paper discusses the science behind the advanced series of bits, including the impact of TMI on cutter performance. New laboratory capabilities and testing results are described, and actual field case histories presented to demonstrate performance improvements of these PDC bits in hard rock applications.
Reduction of cytotoxicity of Myramistin by adsorption on nanodiamonds (2017)

Detonation nanodiamonds, being a good sorbent, were shown to affect considerably cytotoxicity of cationic surfactants and to possess the significant binding efficiency.
SimCalc MathWorlds for the mathematics of change (1996)

article Free Access Share on SimCalc MathWorlds for the mathematics of change Authors: Jeremy Roschelle Univ. of Massachusetts in Dartmount Univ. of Massachusetts in DartmountView Profile , James J. Kaput Univ. of Massachusette in Dartmount Univ. of Massachusette in DartmountView Profile Authors Info & Claims Communications of the ACMVolume 39Issue 8Aug. 1996pp 97–99https://doi.org/10.1145/232014.232041Published:01 August 1996Publication History 14citation497DownloadsMetricsTotal Citations14Total Downloads497Last 12 Months51Last 6 weeks14 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Direct Polymer Additive Tooling - Economic Analysis of Additive Manufacturing Technologies for Fabrication of Polymer Tools for Injection Molding (2020)

This research project aims to analyze the economic feasibility of Additive Manufacturing (AM) as supportive technology in Injection Molding (IM) tool manufacturing by estimating the potential cost-savings and lead-time reduction. Cost and lead-time considerations during small part quantity production are analyzed by developing an extended estimation model for the integration of AM in tool production. Based on six different real reference parts, the developed model shows the projected savings and the current limitations of AM applications in tool production due to material constraints. Furthermore, this extended model offers a holistic view on part cost and lead-time information, by considering tooling as well as production phases in IM and integrating tool life as a key variable. Hence, this research project closes a literature gap and facilitates the integration of AM into the IM process chain.
[Study on the threshold of HIV-1 drug resistance in Hunan province]. (2008)

The first line regiments of national ART seemed still effective. Most of the AIDS patients did not need to be tested on drug resistance status before starting ART. However, it is important to start HIV drug resistance surveillance in no time.
DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties (1998)

Regulation of the IkappaB alpha and IkappaB beta proteins is critical for modulating NF-kappaB-directed gene expression. Both IkappaB alpha and IkappaB beta are substrates for cellular kinases that phosphorylate the amino and carboxy termini of these proteins and regulate their function. In this study, we utilized a biochemical fractionation scheme to purify a kinase activity which phosphorylates residues in the amino and carboxy termini of both IkappaB alpha and IkappaB beta. Peptide microsequence analysis by capillary high-performance liquid chromatography ion trap mass spectroscopy revealed that this kinase was the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK phosphorylates serine residue 36 but not serine residue 32 in the amino terminus of IkappaB alpha and also phosphorylates threonine residue 273 in the carboxy terminus of this protein. To determine the biological relevance of DNA-PK phosphorylation of IkappaB alpha, murine severe combined immunodeficiency (SCID) cell lines which lack the DNA-PKcs gene were analyzed. Gel retardation analysis using extract prepared from these cells demonstrated constitutive nuclear NF-kappaB DNA binding activity, which was not detected in extracts prepared from SCID cells complemented with the human DNA-PKcs gene. Furthermore, IkappaB alpha that was phosphorylated by DNA-PK was a more potent inhibitor of NF-kappaB binding than nonphosphorylated IkappaB alpha. These results suggest that DNA-PK phosphorylation of IkappaB alpha increases its interaction with NF-kappaB to reduce NF-kappaB DNA binding properties.
Dist-GAN: An Improved GAN using Distance Constraints (2018)

We introduce effective training algorithms for Generative Adversarial Networks (GAN) to alleviate mode collapse and gradient vanishing. In our system, we constrain the generator by an Autoencoder (AE). We propose a formulation to consider the reconstructed samples from AE as "real" samples for the discriminator. This couples the convergence of the AE with that of the discriminator, effectively slowing down the convergence of discriminator and reducing gradient vanishing. Importantly, we propose two novel distance constraints to improve the generator. First, we propose a latent-data distance constraint to enforce compatibility between the latent sample distances and the corresponding data sample distances. We use this constraint to explicitly prevent the generator from mode collapse. Second, we propose a discriminator-score distance constraint to align the distribution of the generated samples with that of the real samples through the discriminator score. We use this constraint to guide the generator to synthesize samples that resemble the real ones. Our proposed GAN using these distance constraints, namely Dist-GAN, can achieve better results than state-of-the-art methods across benchmark datasets: synthetic, MNIST, MNIST-1K, CelebA, CIFAR-10 and STL-10 datasets. Our code is published here (https://github.com/tntrung/gan) for research.
TACROLIMUS AND TRANSPLANTATION (2004)

The concept of replacing failing organs or tissues with healthy ones is as old as civilization itself, but it was not until 1954 that the first successful human kidney transplant was performed. Since then, improved surgical techniques and organ preservation, greater understanding of immunologic barriers, and the development of newer and more potent immunosuppressives have combined to make human organ transplantation relatively routine. Key to the success of transplantation is tacrolimus, originally known as FR000506. The compound, which suppresses interleukin-2 production associated with T-cell activation, inhibits differentiation and proliferation of cytotoxic T cells. Today, it is recognized worldwide as the cornerstone of immunosuppressant therapy.
Three-Dimensional Thermoelastic Contact Model of Coated Solids with Frictional Heat Partition Considered (2018)

In this paper, a three-dimensional thermoelastic contact model of coated solids with the frictional heat partition considered is developed by introducing a frictional heat partition model. The influence coefficients of the temperature rise, normal displacement and stress components in the three-dimensional thermoelastic contact model are converted from their corresponding frequency response functions (FRFs) with a conversion method based on the fast Fourier transform (FFT), and the FRFs of solids coated with a homogeneous coating subjected to a coupled action of the mechanical loading and the frictional heat flux on its surface are deduced in the frequency domain by introducing a two-dimensional Fourier integral transform. The contact pressure and the frictional heat partition between the two bodies are solved by employing a fast numerical algorithm based on the conjugate gradient method (CGM) and a discrete convolution fast Fourier transformation (DC-FFT). Comparison between the solutions of the present model and those of a thermoelastic contact model in literature is conducted in order to validate the present model. Several specific conclusions on the effect of the sliding speed, thermoelastic properties and thickness of the coating are drawn based on the result of numerical investigation by utilizing the present model.
Hierarchical Trustworthy Authentication for Pervasive Computing (2007)

Conventional entity authentication is not enough to build a secure pervasive computing environment. Being sure that you are talking to the expected entity does not guarantee it is going to do what you expect him to do, and only that. This paper introduces a concept of "trustworthy authentication" in pervasive computing which is defined as entity authentication accompanied by an assurance of trustworthy behaviour of the authenticated entity. It discusses how to provide trustworthy authentication in pervasive computing using the example of a roaming customer wishing to print his email on a public printer. A two-level hierarchical trustworthy authentication scheme is proposed where local and higher-level authorization servers issue trustworthiness certificates after receiving trustworthiness records from the printer, signed by its users. The proposed scheme may be generalized for trustworthy authentication of security devices such as firewalls.
Design Procedure and Efficiency Analysis of a 99.3% Efficient 10 kW Three-Phase Three-Level Hybrid GaN/Si Active Neutral Point Clamped Converter (2021)

High-efficient and power-dense ac–dc power electronic converters are demanded for a wide range of applications, such as motor drives and active rectifiers. The utilization of wide bandgap devices, such as gallium-nitride (GaN) transistors, is a key feature to improve both the efficiency and the power density of power electronic converters. Owing to the superiority of GaN switches, this article achieves a high-efficiency three-level active-neutral-point-clamped converter. However, using GaN transistors is critically dependent on the layout configuration to achieve smooth switching transient and, as equally important, efficient cooling. Therefore, this article presents layout optimization and considers different layout configurations to achieve a low power loop inductance and as efficient heatsink assembly/performance. Two configurations of the switch boards are built by GaN/Si <sc xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mosfet</small> s, and a power loop inductance comparison is presented. Furthermore, a comprehensive loss model is performed to fine-tune the switching frequency from the efficiency and the size point of view. A 10 kW laboratory prototype voltage source converter, including an electromagnetic interference (EMI) filter, is built with the switching frequency of 140 kHz. The efficiency measurement is performed and confirmed the full load efficiency of 99% and peak efficiency of 99.34%. Moreover, the CISPR11 Class A conducted EMI standard is fulfilled.
Time Optimized Multi-Agent Path Planning using Guided Iterative Prioritized Planning (Extended Abstract) (2013)

paper proposes the guided iterative prioritized planning (GIPP) algorithm to address the problem of moving multiple mobile agents to their respective destinations in a shortest time- related cost. Compared to other MAPP algorithms, the GIPP algorithm strikes a good balance between various performance criteria such as finding feasible solutions, completing the task promptly and low computational cost.
Roles of CD28, CTLA4, and Inducible Costimulator in Acute Graft-versus-Host Disease in Mice (2011)

T cells deficient for CD28 have reduced ability to expand and survive, but still cause graft-versus-host disease (GVHD). Inducible costimulator (ICOS), a member of the CD28 family, is expressed on antigen-activated T cells and plays unique roles in T cell activation and effector function. We hypothesized that ICOS contributes to the development of GVHD in the absence of B7:CD28/CTLA4 costimulation. In this study, we evaluated the roles of CD28, CTLA4, and ICOS in the pathogenesis of acute GVHD after myeloablative allogeneic bone marrow transplantation. Unexpectedly, we found that blocking CD28 and CTLA4 signals using the clinically relevant reagent CTLA4-Ig increases the severity of GVHD mediated by CD4(+) T cells, and that such treatment does not add any benefit to the blockade of ICOS. In contrast, selectively blocking CD28 and ICOS, but not CTLA4, prevents GVHD more effectively than blocking either CD28 or ICOS alone. Taken together, these results indicate that CD28 and ICOS are synergistic in promoting GVHD, whereas the CTLA4 signal is required for T cell tolerance regardless of ICOS signaling. Thus, blocking CD28 and ICOS while sparing CTLA4 represents a promising approach for abrogating pathogenic T cell responses after allogeneic bone marrow transplantation.
Kinetics of coagulation factor-X activation by platelet-bound factor IXa (1990)

Thrombin-activated human platelets, in the presence of factors VIIIa and X, have specific, high-affinity (Kd approximately 0.5 nM), saturable binding sites for factor IXa that are involved in factor X activation [Ahmad, S.S., Rawala-Sheikh, R., & Walsh, P.N. (1989) J. Biol. Chem. 264, 3244-3251]. To determine the functional consequences of factor IXa binding to platelets, a detailed kinetic analysis of the effects of platelets, phospholipids, and factor VIII on factor IXa catalyzed factor X activation was done. In the absence of platelets, phospholipids, or factor VIII, the Michaelis constant (Km = 81 microM) was greater than 500-fold higher than the factor X concentration in human plasma. Unactivated platelets and thrombin-activated factor VIII, alone or in combination, had no effect on the kinetic parameters, whereas thrombin-activated platelets caused a major decrease in Km (0.39 microM) with no significant effect on kcat (0.052 min-1) and allowed factor VIIIa to decrease the Km further to a concentration (0.16 microM) near that of factor X in plasma and to increase the kcat 24,000-fold to 1240 min-1. Sonicated mixed phosphatidylserine/phosphatidylcholine vesicles (25/75, mol/mol) had kinetic effects similar to those of activated platelets. When factor IXa binding to thrombin-activated platelets and rates of factor X activation were measured simultaneously at saturating concentrations of factor X and factor VIIIa, the kcat was independent of factor IXa concentration, and the mean kcat value was 2391 min-1. The increase in catalytic efficiency (kcat/Km) in the presence of thrombin-activated platelets and factor VIIIa was (17.4 x 10(6))-fold.
Clinical correlates of circulating immune complexes and antibody reactivity in squamous cell carcinoma of the head and neck. The Department of Veterans Affairs Laryngeal Cancer Study Group. (1993)

Our results support the conclusion that the formation of tumor-associated immune complexes in patients with SCCHN is associated with a decreased response to chemotherapy.
Stability of furosemide and chlorothiazide stored in syringes (2015)

Solutions of chlorothiazide (10 mg/mL) and furosemide (1 mg/mL) stored either separately or together in polypropylene syringes remained stable for up to 96 hours at room temperature and protected from light.
Desymmetrization of 1,4‐Pentadien‐3‐ol by the Asymmetric 1,3‐Dipolar Cycloaddition of Azomethine Imines (2014)

Desymmetrization of the divinyl carbinol 1,4-pentadien-3-ol was accomplished by the asymmetric 1,3-dipolar cycloaddition of azomethine imines based on a magnesium-mediated, multinucleating chiral reaction system utilizing diisopropyl (R,R)-tartrate as the chiral auxiliary. The corresponding optically active trans-pyrazolidines, each with three contiguous stereogenic centers, were obtained with excellent regio-, diastereo-, and enantioselectivity, with results as high as 99% ee. This reaction was shown to be applicable to both aryl- and alkyl-substituted azomethine imines. The use of a catalytic amount of diisopropyl (R,R)-tartrate was also effective when accompanied by the addition of MgBr2.
Opportunities and constraints for developing a sustainable E-waste management system at local government level in Australia (2009)

E-waste refers to both electronic and electrical waste materials; namely any items which rely on an electric current or electromagnetic fields in order to operate, and contain a hard-drive or significant electronic components and/or a printed circuit board. E-waste is outstripping the general growth of the municipal waste stream. Increasingly, smaller and cheaper electronic items are being disposed of in municipal waste systems and this, coupled with an increase in the number of, and turnover of manufacturers and suppliers, may see local councils assuming a key role in future e-waste management. A survey of local councils across Australia was undertaken to determine the current level of understanding and action on e-waste, and to solicit key responses regarding the identification of areas where improvements could be made. The survey achieved an overall response rate of 35%. Survey results identified key barriers experienced by councils regarding the collection and treatment of e-wastes, such as access to reprocessing facilities and the limited or complete unawareness by the public of the issues. With regards to who should pay for e-waste disposal at end-of-life, consumers and producers were most commonly cited, depending on the state with the preferred funding mechanisms being 'advanced recycling fee' and Expanded Producer Responsibility. Overwhelmingly, 88% of respondents believed that federal legislation was required to manage e-waste. Overall, the results did not indicate differences in views between states for most questions.