gebhart/patrepeval huggingface dataset:
Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading (1999)

The neurofibromatosis 2 ( NF2 ) gene product, merlin, is a tumor suppressor protein mutated in schwanno-mas and several other tumors. Merlin, which shares significant homology with the actin-associated proteins ezrin, radixin and moesin (ERM proteins), inhibits cell growth when overexpressed in cell lines. The similarities between merlin and ERM proteins suggest that merlin's growth-regulatory capabilities may be due to alterations in cytoskeletal function. We examined this possibility in rat schwannoma cell lines overexpressing wild-type merlin isoforms and mutant merlin proteins. We found that overexpression of wild-type merlin resulted in transient alterations in F-actin organization, cell spreading and cell attachment. Merlin overexpression also impaired cell motility as measured in an in vitro motility assay. These effects were only observed in cells overexpressing a merlin isoform capable of inhibiting cell growth and not with mutant merlin molecules (NF2 patient mutations) or a merlin splice variant (isoform II) lacking growth-inhibitory activity. These data indicate that merlin may function to maintain normal cytoskeletal organization, and suggest that merlin's influence on cell growth depends on specific cytoskeletal rearrangements.
A bottleneck prediction and rolling horizon scheme combined dynamic scheduling algorithm for semiconductor wafer fabrication (2014)

Semiconductor wafer fabrication is a very complicated manufacturing system which is characterized by re-entrance production flow, complicated constraints, and dynamic and uncertain environment. Bottleneck is the key factor to the wafer fabrication which has essential influence on the throughput rate, cycle time, time-delivery rate, etc. The optimal scheduling policies for bottleneck machines are conducive to cost decreasing, throughput target achieving and production-resource scheduling improving. In this paper, considering the characteristic information concerning bottleneck and the whole production line, a bottleneck prediction method based on improved adaptive network-based fuzzy inference system (ANFIS) is presented by predicting the wait time of the lot in workstation buffer and the workstation load. Then, based on the obtained bottleneck and directly considering the layer load levels of bottleneck and due date, we proposed a dynamic different layer bottleneck-based scheduling algorithm which includes releasing policy and dispatching algorithm for preventing starvation of bottleneck, balancing work in process (WIP) and higher throughput. Applied to a simulation wafer fabrication, our proposed bottleneck prediction method and bottleneck-based scheduling algorithm can reduced the cycle time and improve machine utility compared with other common heuristic scheduling method.
Clinical features and outcome of crush syndrome caused by the Chi-Chi earthquake. (2002)

CK concentration is a good indicator of the occurrence of acute renal failure and the need for dialysis. The high infection rate and amputation rate after fasciotomy may be due to inadequate debridement. Fasciotomy in crush syndrome patients with high serum CK concentrations should be deliberated.
Chromatograph (Verb) (2019)

Recommendations are given concerning the terminology of methods of separation in analytical chemistry, including chromatography, electromigration techniques, and field-flow fractionation and related techniques.
Assessment of Health Hazards and Challenges among Poultry Workers in Egbeda Local Government Area of Oyo State, Nigeria (2020)

There are many factors that could lead to health hazards among the workers in the poultry business which invariably hamper their production and productivity over time. Hence, a study of assessment of health hazards/challenges among poultry workers in Egbeda local government area of Oyo State, Nigeria was conducted. Purposive sampling was used for selection of 6 villages from the study area while 80 respondents were selected with simple random sampling. Data was analyzed with both descriptive statistics (frequency distribution and simple percentages) and inferential statistics (pearson product moment correlation). The findings revealed some common health hazard challenges experienced as neck pains (53.8%), back pains, (45%), leg pains (41.3%) and general body pains (35%) among the poultry workers. In addition, the findings showed that most respondents in the study area contracted health hazards through injury (68.8%), poor working environments (62.5%) and unhygienic environment (55%). Furthermore, strategies dominantly used in managing the environmental hygiene/health were proper hygiene (81.2%), use of disinfectants (80%), vaccination (76.2%) and physical cleaning and clearing of wastes/dirt’s management (70%). Furthermore, the result revealed that there is significant correlation between management strategies and common hazards experienced by poultry workers in the study area (r = -0.481, p < 0.05). In conclusion, the findings revealed that the poultry workers were predisposed to a number of common health hazards/challenges. It is however recommended that the extension officers should disseminate necessary information management strategies for poultry health hazard. The community health officers should enforce and educate the poultry workers on proper hygiene practices to prevent epidemic in their work environment.
Keywords: Poultry Workers, Health Hazards Challenges, Occupational Work Safety
Supplementary Figure 1 from Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation (2023)

Supplementary Figure 1 from Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation
Optimal route assignment in large scale micro-simulations (2006)

Traffic management and route guidance are optimization problems by nature.In this article, we consider algorithms for centralized route guidance and discuss fairness aspects for the individual user resulting from optimal route guidance policies.The first part of this article deals with the mathematical aspects of these optimization problems from the viewpoint of network flow theory.We present algorithms which solve the constrained multicommodity minimum cost flow problem (CMCF) to optimality.A feasible routing is given by a flow x, and the cost of flow x is the total travel time spent in the network.The corresponding optimum is a restricted system optimum with a globally controlled constrained or fairness factor .This approach implements a compromise between user equilibrium and system optimum.The goal is to find a route guidance strategy which minimizes global and community criteria with individual needs as constraints.The fairness factor L restricts the set of all feasible routes to the subset of acceptable routes.This might include the avoidance of routes which are much longer than shortest routes, the exclusion of certain streets, preferences for scenic paths, or restrictions on the number of turns to be taken.Most remarkably is that the subset of acceptable routes can also be interpreted as a mental map of routes.In the second part we apply our CMCF algorithms in a large scale multi-agent transportation simulation toolkit, which is called MATSIM-T.We use as initial routes the ones computed by our CMCF algorithms.This choice of initial routes makes it possible to exploit the optimization potential within the simulation much better then it was done before.The result is a speed up of the iteration process in the simulation.We compare the existing simulation toolkit with the new integration of CMCF to proof our results.
Monosodium urate crystals in inflammation and immunity (2009)

Uric acid crystals [monosodium urate (MSU)] have emerged as an important factor for both gouty arthritis and immune regulation. This simple crystalline structure appears to activate innate host defense mechanisms in multiple ways and triggers robust inflammation and immune activation. The recognition mechanisms of MSU following its phase change from soluble uric acid are diverse, involving both protein receptors and non-specific plasma membrane attachment. Upon contact with host cells, MSU induces a set of membrane events that trigger Syk and PI3K activation, phagocytosis, and cytokine production. Having entered the cell, MSU further triggers NALP3 inflammasome activation and induces the production of IL-1 beta, likely inducing a full spectrum of inflammation. This review describes the recognition mechanisms and activation pathways involved in MSU-mediated inflammation and adjuvanticity and hypothesizes that direct membrane binding by solid surfaces, such as MSU, may function as a generic mechanism in tissue responses to particulate and crystalline structures.
Supplementary Figure 5 from DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway (2023)

&lt;p&gt;Figure S5 shows the effect of DCLK1-S re-expression on DCLK1-L mRNA level.&lt;/p&gt;
Evaluation of an immunoseparation method for quantitative measurement of remnant-like particle-cholesterol in serum and plasma (1998)

Substantial evidence indicates that triglyceride-rich lipoprotein remnants are atherogenic. Additional research has, however, been limited by available methods for separation and quantification of remnants. We have evaluated an immunoseparation assay developed to measure cholesterol in remnant-like particles (RLP-C). This method uses monoclonal antibodies to human apolipoproteins B-100 and A-I to remove most of the apolipoprotein B-100-containing lipoproteins (namely LDL and nascent VLDL) and apolipoprotein A-I-containing lipoproteins (namely chylomicrons and HDL), leaving behind a fraction of triglyceride-rich lipoproteins, including chylomicron and VLDL remnants, both of which are enriched in apolipoprotein E. Cholesterol in the unbound fraction is measured with a sensitive enzymatic assay. The RLP-C concentration was highly correlated with total triglyceride-rich lipoproteins (sum of VLDL-cholesterol and IDL-cholesterol) separated by ultracentrifugation and by polyacrylamide gel electrophoresis (r = 0.86 and 0.76, respectively). The within-run and run-to-run imprecision (CV) of the assay was approximately 6% and 10%, respectively. The assay was not affected by hemoglobin up to 5000 mg/L (500 mg/dL), bilirubin up to 342 mmol/L (20 mg/dL), glucose up to 67 mmol/L (1200 mg/dL), or ascorbic acid up to 170 mmol/L (3.0 mg/dL). In 726 subjects (men, n = 364; women, n = 362) in the US, the 75th percentiles of RLP-C concentration were 0.17 mmol/L (6.6 mg/dL) and 0.23 mmol/L (8.8 mg/dL) in sera obtained after overnight fasting or randomly, respectively. A group of 151 patients from nine US centers and one Canadian center with coronary artery atherosclerosis established by angiography had higher median RLP-C concentrations than 302 gender- and age-matched controls (P <0.05). We conclude that the RLP-C assay compares favorably to ultracentrifugation and electrophoresis and provides a convenient and economical approach to measure triglyceride-rich lipoprotein remnants in routine clinical laboratories.
Algorithm 737: INTLIB—a portable Fortran 77 interval standard-function library (1994)

INTLIB is meant to be a readily available, portable, exhaustively documented interval arithmetic library, written in standard Fortran 77. Its underlying philosophy is to provide a standard for interval operations to aid in efficiently transporting programs involving interval arithmetic. The model is the BLAS package, for basic linear algebra operations. The library is composed of elementary interval arithmetic routines, standard function routines for interval data and values, and utility routines. The library can be used with INTBIS (Algorithm 681), and a Fortran 90 module to use the library to define an interval data type is available from the first author.
Checkerboard: A Regular Structure and its Synthesis (2003)

Abstract — A regular circuit structure called a Checkerboard (CB) is proposed. In some CB configurations, all mask layers except the via layers are pre-designed, which is attractive for high manufacturability and performance predictability and for lowering mask costs. The synthesis algorithms developed for the CB makes use of their structural regularity and flexibility. No technology mapping is needed; placement and routing are integrated. Experimental results are favorable for CB up to about 10k gates, compared to other structures such as standard cells. For example, the Vk-CB version of CB uses on average only about 4 % more area but is 8 % faster. 1.
Synthesis of aza-macrocycles from polycyclic 5-aminoisoxazoline precursors (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of aza-macrocycles from polycyclic 5-aminoisoxazoline precursorsMark P. Wentland, Rudolph K. Kullnig, and Fook S. ThamCite this: J. Org. Chem. 1991, 56, 15, 4701–4706Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00015a025https://doi.org/10.1021/jo00015a025research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Predicting the pore-filling ratio in lumen-impregnated wood (2017)

Lumen impregnation, unlike most other wood modification methods, is typically assessed by the pore-filling ratio (PFR) (i.e. the fraction of luminal porosity filled) rather than by weight percentage gain (WPG). During lumen impregnation, the impregnants act on the voids in the wood rather than on the solid mass (e.g. cell walls), but the PFR cannot be measured as conveniently as the WPG during processing. Here, it is demonstrated how the PFR can be calculated directly from the WPG if the bulk density of the untreated wood is known. The relationship between the WPG and bulk density was examined experimentally by applying a pressured impregnation on knot-free specimens from Sitka spruce with a liquid mixture of methacrylate monomers. Based on the validated model, it was possible to further study the effect of different process-related parameters, such as hydraulic pressure, on lumen impregnation. Skeletal density is another key parameter in this model, which directly reflects the amount of inaccessible pores and closed lumens, and can be independently determined by helium pycnometry. The permeability can be qualitatively evaluated by PFR as well as skeletal density. For instance, poor permeability of knotty wood, due to the large extractives content around knots, was reflected by a lower skeletal density and inefficient lumen impregnation (low PFR). Although this model was examined on a laboratory scale, it provides guidance on the precise effect of different parameters on lumen impregnation, thereby improving the fundamental understanding of and enabling better control over the modification of wood by impregnation.
High-Throughput Screening of Drug–Lipid Membrane Interactions via Counter-Propagating Second Harmonic Generation Imaging (2011)

Here we report the use of counter-propagating second harmonic generation (SHG) to image the interactions between the local anesthetic tetracaine and a multicomponent planar supported lipid bilayer array in a label-free manner. The lipid bilayer arrays, prepared using a 3D continuous flow microspotter, allow the effects of lipid phase and cholesterol content on tetracaine binding to be examined simultaneously. SHG images show that tetracaine has a higher binding affinity to liquid-crystalline phase lipids than to solid-gel phase lipids. The presence of 28 mol % cholesterol decreased the binding affinity of tetracaine to bilayers composed of the mixed chain lipid, 1-steroyl-2-oleoyl-sn-glycero-3-phophocholine (SOPC), and the saturated lipids 1,2-dimyristoyl-sn-glycero-3-phophocholine (DMPC) and 1,2-dipamitoyl-sn-glycero-3-phophocholine (DPPC) while having no effect on diunsaturated 1,2-dioleoyl-sn-glycero-3-phophocholine (DOPC). The maximum surface excess of tetracaine increases with the degree of unsaturation of the phospholipids and decreases with cholesterol in the lipid bilayers. The paper demonstrates that SHG imaging is a sensitive technique that can directly image and quantitatively measure the association of a drug to a multicomponent lipid bilayer array, providing a high-throughput means to assess drug-membrane interactions.
Spatial distortion correction and crystal identification for position-sensitive avalanche photodiode-based PET scanners (2008)

Position-sensitive avalanche photodiodes (PSAPDs) are gaining widespread acceptance in modern PET scanner designs, and owing to their relative insensitivity to magnetic fields, especially in those that are MRI-compatible. Flood histograms in PET scanners are used to determine the crystal of annihilation photon interaction and hence, for detector characterization and routine quality control. For PET detectors that use PSAPDs, flood histograms show a characteristic pincushion distortion when Anger logic is used for event positioning. A small rotation in the flood histogram is also observed when the detectors are placed in a magnetic field. We first present a general purpose automatic method for spatial distortion correction for flood histograms of PSAPD-based PET detectors when placed both inside and outside a MRI scanner. Analytical formulae derived for this scheme are based on a hybrid approach that combines desirable properties from two existing event positioning schemes. The rotation of the flood histogram due to the magnetic field is determined iteratively and is accounted for in the scheme. We then provide implementation details of a method for crystal identification we have previously proposed and evaluate it for cases when the PET scanner is both outside and in a magnetic field. In this scheme, Fourier analysis is used to generate a lower-order spatial approximation of the distortion-corrected PSAPD flood histogram, which we call the ‘template‘. The template is then registered to the flood histogram using a diffeomorphic iterative intensity-based warping scheme. The calculated deformation field is then applied to the segmentation of the template to obtain a segmentation of the flood histogram. A manual correction tool is also developed for exceptional cases. We present a quantitative assessment of the proposed distortion correction scheme and crystal identification method against conventional methods. Our results indicate that our proposed methods lead to a large reduction in manual labor and indeed can routinely be used for calibration and characterization studies in MRI-compatible PET scanners based on PSAPDs.
Oxime‐Based Synthesis of New Chromogenic and Fluorogenic Oligosaccharides (2008)

Abstract A new simple approach for the synthesis of labelled oligosaccharides is described. Free synthetic carbohydrate recognition building blocks were conjugated with fluorogenic and chromogenic dyes under mild experimental conditions by using oxime ligation. The resulting oligosaccharide probes presenting well‐defined anomer configuration might find broad interests for recognition studies with a large panel of carbohydrate‐binding proteins. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Structured base hot-electron transistors (1988)

It is proposed that superlattices can be used to 'engineer' certain scattering rates and hot-carrier transport properties with important implications for hot-electron devices. In particular, calculations indicate a possibility to engineer the superlattice band structure to achieve high built-in fields for higher mini-bands with zero built-in field for the lowest mini-band. By using such built-in fields it is estimated that the current gain ( beta ) for a hot-electron transistor employing a suitable superlattice for the base region can be increased by a large factor ( approximately=30) compared with conventional structures.
Developments in the diagnostic mycology laboratory (1992)

Journal Article Developments in the diagnostic mycology laboratory Get access G.D. Roberts, G.D. Roberts Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. Pfaller, M.A. Pfaller Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Gueho, E. Gueho Search for other works by this author on: Oxford Academic PubMed Google Scholar T.R. Rogers, T.R. Rogers Search for other works by this author on: Oxford Academic PubMed Google Scholar C. De Vroey, C. De Vroey Search for other works by this author on: Oxford Academic PubMed Google Scholar W.G. Merz W.G. Merz Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Medical and Veterinary Mycology, Volume 30, Issue Supplement_1, January 1992, Pages 241–248, https://doi.org/10.1080/02681219280000931 Published: 01 January 1992
Facial feature detection using compact vector-field canonical templates (2002)

Detecting and analyzing prominent facial regions forms the fundamental building block in most face recognition systems. Prominent regions such as left and right eyes, tip of the nose, mouth, etc. are localized to derive an overall representation of the face being recognized. In this paper, we present a method for deriving a set of compact translation-, scale- and rotation-invariant canonical templates which could be used on a large database. In contrast to conventional gray scale templates, these are of the 2D gradient field type. Facial feature detection is based on evidential reasoning from the measures of belief and disbelief estimations. The above method is demonstrated on a facial image database of size 137 using only 9-left, 9-right and 9-nose tip canonical templates.
Web Tap Payment Authentication and Encryption With Zero Customer Effort. (2014)

Abstract. We propose a public-key authentication and encryption ap-plication that secures the messages between Tap-Card-Pay application, Tap-Card-Pay Systems Corporation, customers, and merchants allowing the customer to complete transactions without requiring the customer to input sensitive information. With authentication and encryption, the application transfers the credit card information from the smartphone&amp;apos;s near eld communication device onto the merchant webpage. Security weaknesses are also presented to show how to attack this design.
ChemInform Abstract: REACTION OF TRITHIAZYL CHLORIDE WITH TITANIUM TETRACHLORIDE. CRYSTAL STRUCTURE OF (S4N5)2(TI2CL10) (1985)

Abstract Die Titelverbindung (IV) wird gemäß Formelschema als ein Nebenprodukt der Umsetzung von Trithiazylchlorid mit TiCl 4 in CCl 4 in Form brauner Nadeln erhalten (keine Ausb.‐Angabe).