gebhart/patrepeval huggingface dataset:
[Antiparasitic effect of Senegalese Annonaceae used in traditional medicine]. (2003)

Annonaceae is a large family of plants widely used in alimentation and traditional medicine. The interest of their study is raised up by the presence of biologically active substances among that the acetogenins which are specific to them. In Senegal, three species are widely used in traditional medicine for various indications and particularly in parasitic diseases: Annona senegalensis, Uvaria chamae and Xylopia aethiopica. The study of antiparasitical extracts from various organs showed an interesting activity of the fruits and leaves of Xylopia aethiopica on Leishmania donovani, the stem barks and roots of Uvaria chamae on Trypanosomia brucei and the roots of Annona senegalensis on the chloroquino-resistant strain of Plasmodium falciparum. Bioguided fractionation of the active extracts led to isolate Annonaceous acetogenins. Therefore, thirteen acetogenins, from the roots of Uvaria chamae and Annona senegalensis, were identified. The presence of acetogenins, substances with antiparasitical activity, could partly explain the biological proprieties of these various drugs.
Inversion and Attribute Assisted Hydraulic Fracture Characterization in South Texas Barnett Formation (2011)

Passive seismic methods which use no active human-build source, but utilise the natural sounds of the earth, produce in most cases a low resolution of the subsurface compared to active seismic. Due to the usually low-frequency content of the earth’s seismic sources, they are often dismissed and not even considered as an add-on for an active-seismic campaign. And this, despite a similar resolution than gravimetric methods, minimal costs compared to an active survey, the same “domain” as active seismics, and their environmental friendliness. The abstract will introduce 6 passive-seismic methods which can be used for hydrocarbon exploration. It will try to rank the different methods and suggest possible applications and integration with active seismic data.
Unbalanced fault analysis of doubly fed induction generator drive system for wind turbine applications (2013)

This paper presents detailed analysis of the doubly fed induction generator (DFIG), converters and step-up transformer under normal and fault conditions for wind turbine applications. 2.5 MW DFIG is modeled through finite element analysis in Ansoft-Maxwell, and the simulation is coupled to Ansoft-Simplorer and Matlab-Simulink for the drive circuit and controller implementation. Single phase to ground short circuit which has the highest probability to occur in the grid is tested through coupled simulators. The effect of short circuit stator current on the rotor currents are analyzed for rotor side converter protection. The FFT analysis of the stator and rotor fluxes in simulation during fault conditions are carried to be able to develop advanced control techniques in eliminating the harmonics and protecting the overall drive system. Experimental 7.5 HP DFIG test system has been developed to verify the simulation results. The FFT analysis of stator fluxes under fault condition from experimental results agrees well with the simulation results.
A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping (2016)

Focused ultrasound (FUS) phased arrays show promise for non-invasive brain therapy. However, the majority of them are limited to a single transmit/receive frequency and therefore lack the versatility to expose and monitor the treatment volume. Multi-frequency arrays could offer variable transmit focal sizes under a fixed aperture, and detect different spectral content on receive for imaging purposes. Here, a three-frequency (306, 612, and 1224 kHz) sparse hemispherical ultrasound phased array (31.8 cm aperture; 128 transducer modules) was constructed and evaluated for microbubble-mediated transcranial therapy and simultaneous cavitation mapping. The array is able to perform effective electronic beam steering over a volume spanning (-40, 40) and (-30, 50) mm in the lateral and axial directions, respectively. The focal size at the geometric center is approximately 0.9 (2.1) mm, 1.7 (3.9) mm, and 3.1 (6.5) mm in lateral (axial) pressure full width at half maximum (FWHM) at 1224, 612, and 306 kHz, respectively. The array was also found capable of dual-frequency excitation and simultaneous multi-foci sonication, which enables the future exploration of more complex exposure strategies. Passive acoustic mapping of dilute microbubble clouds demonstrated that the point spread function of the receive array has a lateral (axial) intensity FWHM between 0.8-3.5 mm (1.7-11.7 mm) over a volume spanning (-25, 25) mm in both the lateral and axial directions, depending on the transmit/receive frequency combination and the imaging location. The device enabled both half and second harmonic imaging through the intact skull, which may be useful for improving the contrast-to-tissue ratio or imaging resolution, respectively. Preliminary in vivo experiments demonstrated the system's ability to induce blood-brain barrier opening and simultaneously spatially map microbubble cavitation activity in a rat model. This work presents a tool to investigate optimal strategies for non-thermal FUS brain therapy and concurrent microbubble cavitation monitoring through the availability of multiple frequencies.
Rapid patching of concrete using polymer concrete (1978)

One of the major problems confronting the highway industry today is the need for a rapid repair material for deteriorated concrete structures. High maintenance costs and traffic delays have created the need for a long lasting, rapid setting, concrete patching material. The use of polymer concrete (PC) as a repair material is discussed. Materials used to make polymer concrete composites are described, as is the procedure for placing polymer concrete patches. The placement of polymer concrete patches in the field by highway maintenance personnel using conventional concrete mixing equipment and techniques is also described.
Unroofed Coronary Sinus - A Rare Type of ASD (2012)

Clinical History A 53-year old man presented to the cardiology clinic with a shortness of breath and atrial fibrillation with a rapid ventricular response. His past medical history was remarkable for hypertension, hyperlipidemia and a non ST segment elevation myocardial ischemia. A computed tomography angiogram (CTA) evaluation of the pulmonary veins was requested as a part of pre-procedural work up for endovascular pulmonary vein isolation.
3D printed microfluidic modules: passive mixers and cells encapsulation in alginate (2022)

Abstract passive mixers and droplet generation microfluidic chip modules were designed and manufactured using a commercial SLA 3D-printer. The mixing modules were designed specifically for 3D-printing and evaluated using FEM modeling. The co-flow droplet generator was used for cancer cells encapsulation and drug potency evaluation.
Tuileries—philippe-auguste: The first fully engineered high capacity junction line in paris (1982)

Abstract For many years, the French PTT has devoted great effort for the development of optical fiber systems. Today, several types of applications are planned in the local, urban, or trunk networks. We report here the results of the first junction line, at 0,85 μm, which was installed in August 1980 in Paris. This line consists of a 70-fiber cable pulled over a distance of 7,5 km between two exchange centers, Tuileries and Philippe-Auguste. The bit rate is 34 Mb/s, leading to a potential capacity of 16 800-bidirectional channels.
Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds (2014)

Toll-like receptor (TLR) 7 and 8 agonists are potential vaccine adjuvants, since they directly activate APCs and enhance Th1-driven immune responses. Previous SAR investigations in several scaffolds of small molecule TLR7/8 activators pointed to the strict dependence of the selectivity for TLR7 vis-à-vis TLR8 on the electronic configurations of the heterocyclic systems, which we sought to examine quantitatively with the goal of developing "heuristics" to define structural requisites governing activity at TLR7 and/or TLR8. We undertook a scaffold-hopping approach, entailing the syntheses and biological evaluations of 13 different chemotypes. Crystal structures of TLR8 in complex with the two most active compounds confirmed important binding interactions playing a key role in ligand occupancy and biological activity. Density functional theory based quantum chemical calculations on these compounds followed by linear discriminant analyses permitted the classification of inactive, TLR8-active, and TLR7/8 dual-active compounds, confirming the critical role of partial charges in determining biological activity.
Commercially Available Nitrate Ionophores in Potentiometric Sensors are not Superior to Common Ion‐exchangers (2022)

Abstract Nitrate sensing is an important application for potentiometry in environmental applications. Its recognition is by ion‐exchangers whose selectivity is governed by the lipophilicity of the ions in solution. Yet, considerable research efforts have been dedicated to the development of such ionophores and some have already been commercialized. This work examines two commercially available nitrate ionophores, nitrate ionophores V and VI, and compares their performance with widely used ion‐exchangers by determining the resulting membrane selectivity and complexation to nitrate. Unfortunately, adding a nitrate ionophore to the membrane did not result in improved selectivity. Sandwich membrane experiments indicated that binding interaction is too weak to be measurable, with a logarithmic formation constant of just 1.36±0.14 for ionophore V with nitrate. Ways to improve the reporting of relevant data are suggested.
Effets de l'arthrodèse tibio-talienne sur la dynamique du pied au cours de la marche (2003)

Texte intégral accessible uniquement aux membres de l'Université de Lorraine
When Occlusions are Outliers (2006)

In many tracking applications, the deformable object of interest suffers from frequent occlusions. Traditional augmenting methods use templates and measures of similarity to recover from occlusions. In this paper, we break with these methods. Instead, we model bad image correspondences, which are induced by occlusions, as statistical outliers in the context of tracking high-dimensional deformable models. This interpretation allows us to use robust statistical estimators in the deformable model’s parameter space to detect and eliminate such outliers. Because fast-moving occlusions can generate an excessively large outlier to inlier ratio in the occluded areas, we combine the robust statistical estimation with an initial rejection of correspondences based on the magnitude of the optical flow, a simple 2D criterion. To improve robustness even further, we have the final outlier rejection test take into account both the statistical distribution of the deformable model’s parameters, and that different parameters are affected by different subsets of correspondences. We validate and demonstrate our technique on real sequences of American Sign Language, which exhibit frequent and extensive occlusions caused by fast movement of the subjects’ hands.
195. Dimolybdenum carbide (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT195. Dimolybdenum carbideR. J. Fries and Charles P. KempterCite this: Anal. Chem. 1960, 32, 13, 1898Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://doi.org/10.1021/ac50153a061Request reuse permissionsArticle Views158Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (143 KB) Get e-Alertsclose Get e-Alerts
Analysis of two‐dimensional electrophoretic patterns of proteins obtained from the sera of normal and tumorbearing nude rats (1991)

To classify two-dimensional electrophoresis (2-DE) patterns of normal and abnormal samples, a new parameter, named shift value, is introduced. The shift value is defined by the product of three indices; differences in density, differences in area, and the Euclid distance between peaks of matched glycoprotein spots in the 2-DE patterns. Shift values obtained from the differences between the 2-DE patterns of tumor-bearing and normal sera (control) were always found to be larger than those obtained from two control patterns. The shift value obtained from glycoprotein spots could be more effectively used to distinguish normal and abnormal patterns than that obtained from simple proteins. In our earlier attempts to compare serum proteins of normal and tumor patients, we could not discriminate differences caused by genetic background. In order to circumvent this difficulty, we employed an inbred strain of nude rats into which various types of human cancer had been implanted. Reliability of the analysis is enhanced by using a polyacrylamide gel backed with a silanized glass support and an automatic 2-DE apparatus.
Synthesis, characterization, and thermal properties of anhydride terminated and allyl terminated oligoimides (2000)

This study concerns the synthesis of anhydride terminated oligoimides (ANTOI) and allyl terminated oligoimides (ALTOI), in acetic acid medium, which allows a very fast reaction and an easy working out. For the preparation of ALTOIs, two methods are compared: the first one consists of adding the monofunctional compound (allyl amine) to the ANTOI already formed during a first step by reaction of a dianhydride (excess) and a diamine. The second method consists of a “one pot” reaction between the dianhydride, the diamine, and the monofunctional allyl–amine compounds, at the beginning of the reaction. The experimental results show that the best control of the molecular weights is obtained with the first method. If the amount of allyl amine is higher than the amount necessary to end cap the ANTOI, a transimidization reaction occurs. Thermal analyses of oligoimides terminated by anhydride or allyl groups have been performed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Transition and thermoresistance properties make ANTOI and ALTOI derivatives interesting as precursors for block polyimide copolymers. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 2993–3003, 2000
Characterizing the Variance of Mechanical Properties of Sunflower Bark for Biocomposite Applications (2013)

Characterizing the variance of material properties of natural fibers is of growing concern due to a wide range of new engineering applications when utilizing these natural fibers. The aim of this study was to evaluate the variance of the Young's modulus of sunflower bark by (i) determining its statistical probability distribution, (ii) investigating its relationship with relative humidity, and (iii) characterizing its relationship with the specimen extraction location. To this end, specimens were extracted at three different locations along the stems. They were also preconditioned in three different relative humidity environments. The 2 -test was used for hypothesis testing with normal, Weibull, and log-normal distributions. Results show that the Young's modulus follows a normal distribution. Two-sample t-test results reveal that the Young's modulus of sunflower stem bark strongly depends on the conditioning's relative humidity and the specimen's extraction location; it significantly decreased as the relative humidity increased and significantly increased from the bottom to the top of the stem. The correlation coefficients between the Young's modulus of different relative humidity values and of specimen extraction locations were determined. The calculation of correlation coefficients shows a linear relation between the Young's modulus and the relative humidity for a given location.
An integrated vent, heatsink and EMI shield (2003)

A vent component made of a thermally and electrically conductive material was developed to replace a part of or the whole conventional vent element of an electronic equipment enclosure, and also to serve simultaneously as a heatsink and an electromagnetic interference (EMI) shield. By thermally connecting IC devices to the vent component using a high efficiency transfer medium, the sidewalls of vent holes act as extended surface of a heatsink. In the meantime, vent holes with a given thickness become waveguides that prevent EMI leakage from the apertures. As such, the integrated vent component has a major advantage over the conventional design in that EMI and thermal aspects of the enclosure design are actually implementing each other; what makes an effective heatsink with large number of small holes and a thick wall will also result in an effective EMI shield. Additionally, this vent component turned heatsink will receive 100% cooling air thus rendering optimal thermal management solutions in terms of heatsink volume and fan power management. Further, the heatsink is remote to heat sources and will consequently have far less space restrictions thus allowing larger heatsinks to accommodate larger thermal loads and yielding higher packaging density at the same time.
SAPROCAN: Saracatinib (AZD0530) and docetaxel in metastatic,castrate-refractory prostate cancer (mCRPC)—A phase I/randomized phase II study by the United Kingdom National Cancer Research Institute Prostate Group. (2021)

107 Background: Saracatinib is an orally-available, highly selective inhibitor of Abl and Src family members. It is an ATP-competitive tyrosine kinase inhibitor. Preclinical data suggested that the combination of a Src kinase inhibitor and docetaxel is synergistic, and Src kinase activity was also implicated in the bone’s metabolic response to cancer metastases. Methods: Patients with mCRPC were initially enrolled in an open-label, dose escalation phase I trial of oral saracatinib (cohorts of 50mg, 125mg and 175mg daily) with docetaxel (75mg/m 2 ) in a 3+3 design. Subsequent patients were randomised 1:1 between saracatinib 175mg and placebo once daily. Pharmacokinetics (PK) of docetaxel were explored in phase I to exclude significant drug-drug interaction. The primary endpoint of phase II was biochemical or radiographic progression free survival (PFS). Secondary endpoints included overall survival (OS), safety and tolerability. Changes in circulating tumour cell (CTC) counts were also measured. The phase II was designed with a 1-sided alpha of 0.2 with 90% power to detect a hazard ratio (HR) for PFS of 0.67. Results: 10 patients were enrolled in phase I and 142 in the randomised phase II. No dose limiting toxicities or PK interactions were observed and the recommended dose for phase II was 175mg saracatinib daily and 75mg/m 2 docetaxel every 21 days. In phase II, the HR for PFS was 1.35 (80% confidence interval (CI) 1.07 to 1.70). The HR for OS was 1.42 (1.08 – 1.81). 41/71 and 29/71 experienced treatment related toxicities of grade 3 or above in the saracatinib and placebo arms respectively. 10/19 (53%) and 14/27 (52%) evaluable patients demonstrated a reduction in CTCs from ≥5 to &lt; 5 /7.5ml blood at 6 weeks after starting saracatinib and placebo respectively. Conclusions: Saracatinib, in combination with docetaxel, adds toxicity and not efficacy in mCRPC. This combination should not be developed further in combination with docetaxel in the treatment of mCRPC. Clinical trial information: ISRCTN22566729.
A Convenient Access to Chiral Sulfonic Acids (1990)

Abstract Neomenthyl and trans myrtanyl sulfonic acids are obtained, free from inorganic salts, starting from the corresponding chiral alcohols.
Nonlinear dynamics of chaotic double-loop sigma-delta modulation (2002)

The double-loop sigma-delta modulator is playing an increasingly important role in signal-processing applications, but this role is often hampered by the appearance of unwanted periodic signals in the modulator output. Operation in a chaotic regime has been suggested as a possible means of overcoming this disadvantage. For some parameter values, however, chaotic operation can lead to unbounded state variables, destroying the functionality of the modulator. State variables that, though bounded, exceed implementation-dependent limits can also destroy functionality. The aim of this paper is to show how established methods of nonlinear dynamics can be applied to the zero-input system to study the steady-state location of the state variables and to determine parameter values for which rounded behaviour is possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Combining collaborative filtering with personal agents for better recommendations (1999)

Information filtering agents and collaborative filtering both attempt to alleviate information overload by identifying which items a user will find worthwhile. Information filtering (IF) focuses on the analysis of item content and the development of a personal user interest profile. Collaborative filtering (CF) focuses on identification of other users with similar tastes and the use of their opinions to recommend items. Each technique has advantages and limitations that suggest that the two could be beneficially combined. This paper shows that a CF framework can be used to combine personal IF agents and the opinions of a community of users to produce better recommendations than either agents or users can produce alone. It also shows that using CF to create a personal combination of a set of agents produces better results than either individual agents or other combination mechanisms. One key implication of these results is that users can avoid having to select among agents; they can use them all and let the CF framework select the best ones for them.
[A Case of Minimally Invasive Apocrine Carcinoma Derived from Ductal Adenoma]. (2016)

A 63-year-old woman was found to have a mass in her right breast and visited our hospital to undergo a detailed examination. A histopathological examination by using ultrasound-guided core needle biopsy revealed ductal carcinoma in situ. A partial mastectomy with sentinel lymph node biopsy was performed for the cancer of the right breast. The postoperative histopathological examination indicated apocrine carcinoma with a predominantly intraductal component without lymph node metastasis. The discrimination between ductal adenoma and apocrine carcinoma sometimes becomes a problem in making decisions about treatment. We need to take care when making a diagnosis.