gebhart/patrepeval huggingface dataset:
Poly(triphenyl ethene) and poly(tetraphenyl ethene): synthesis, aggregation-induced emission property and application as paper sensors for effective nitro-compounds detection (2016)

This paper reports two structurally unique aggregation-induced emission (AIE) polymers that are fully constructed by AIE luminogen tetraphenyl or triphenyl ethene units. Their applications as paper sensors are studied.
Temporal Convolutional Neural Network for the Classification of Satellite Image Time Series (2019)

Latest remote sensing sensors are capable of acquiring high spatial and spectral Satellite Image Time Series (SITS) of the world. These image series are a key component of classification systems that aim at obtaining up-to-date and accurate land cover maps of the Earth’s surfaces. More specifically, current SITS combine high temporal, spectral and spatial resolutions, which makes it possible to closely monitor vegetation dynamics. Although traditional classification algorithms, such as Random Forest (RF), have been successfully applied to create land cover maps from SITS, these algorithms do not make the most of the temporal domain. This paper proposes a comprehensive study of Temporal Convolutional Neural Networks (TempCNNs), a deep learning approach which applies convolutions in the temporal dimension in order to automatically learn temporal (and spectral) features. The goal of this paper is to quantitatively and qualitatively evaluate the contribution of TempCNNs for SITS classification, as compared to RF and Recurrent Neural Networks (RNNs) —a standard deep learning approach that is particularly suited to temporal data. We carry out experiments on Formosat-2 scene with 46 images and one million labelled time series. The experimental results show that TempCNNs are more accurate than the current state of the art for SITS classification. We provide some general guidelines on the network architecture, common regularization mechanisms, and hyper-parameter values such as batch size; we also draw out some differences with standard results in computer vision (e.g., about pooling layers). Finally, we assess the visual quality of the land cover maps produced by TempCNNs.
Synthesis of diverse spiroisoxazolidinohydantoins by totally regio- and diasteroselective 1,3-dipolar cycloadditions (2011)

5-Carboxymethylene hydantoins have been synthesized in high yield and under very mild conditions (20 °C, dichloromethane) through a highly (often totally) regio- and diastereoselective domino process involving readily accessible carbodiimides and acetylenedicarboxylic acid monoesters. Such compounds could be considered very intriguing intermediates for the preparation of spirohydantoins and other hydantoin derivatives. For instance, they react smoothly with either acyclic and cyclic nitrones to form spiroisoxazolidinohydantoins in high yield and with total control of the regio- and diastereoselectivity. Starting from an enantiomerically pure chiral pyrroline nitrone, the reaction was also enantiospecific. Both processes have been studied in detail and the diastereoselectivities seen have been rationalized upon examination of the alternative transition states and by density functional theory calculations of the cycloaddition step.
Application of advanced signal processing methods for accurate detection of voltage dips (2008)

Custom Power Devices like the dynamic voltage restorer have been applied for voltage dip mitigation in the last years. These electronic equipments need fast and reliable voltage dip detection algorithms. Such detection methodologies must be able to detect a voltage dip as fast as possible and be immune to other types of perturbations. In this paper we address the problem of voltage dip estimation by using different advanced signal processing methods such as Kalman filtering, Fourier based algorithms and Wavelet processing. The three algorithms have been tested under different conditions: voltage dip with phase jump, noise, frequency variations. The final implementation on a Texas Instrument DSP TMS320F2812DSP has been done.
Analysis of the processing and transmembrane topology of the E2p7 protein of hepatitis C virus (2005)

Hepatitis C virus C, E1, E2 and p7 proteins are cleaved from a viral polyprotein by host signal peptidases. Cleavage at the E2/p7 site is incomplete in genotype 1a strain H (resulting in E2, p7 and E2p7 species), although it has been reported to be more efficient in genotype 1b strain BK. Here, the proteolytic processing and transmembrane topology of genotype 1a strain H77c p7 was investigated when expressed in the context of E2p7. Partial processing was seen at the E2/p7 site in mammalian cells, the efficiency of which improved in the presence of nucleotide sequences downstream of p7. In insect cells, no processing at the E2/p7 site occurred and the uncleaved E2p7 species was incorporated into virus-like particles when expressed in the context of CE1E2p7c-myc. E2p7c-myc formed a heterodimer with E1, indicating that, like the well-characterized E1-E2 complex, the E1-E2p7 heterodimer may also play a functional role in virus replication. Comparison of the p7 signal peptide sequences of strains BK and H77c revealed 3 aa differences (positions 720, 733 and 742). Mutational analysis showed that the V720L change in the H77c sequence substantially increased processivity at the E2/p7 site. The p7 protein adopts a double membrane-spanning topology with both its N and C termini orientated luminally in the endoplasmic reticulum. The transmembrane topology of E2p7 species was examined by two independent means. In both cases, the C terminus of p7 in E2p7 was found to be cytoplasmically orientated, indicating that p7 adopts a dual transmembrane topology.
Hologram synthesis for photorealistic reconstruction (2008)

Computation of diffraction patterns, and thus holograms, of scenes with photorealistic properties is a highly complicated and demanding process. An algorithm, based primarily on computer graphics methods, for computing full-parallax diffraction patterns of complicated surfaces with realistic texture and reflectivity properties is proposed and tested. The algorithm is implemented on single-CPU, multiple-CPU and GPU platforms. An alternative algorithm, which implements reduced occlusion diffraction patterns for much faster but somewhat lower quality results, is also developed and tested. The algorithms allow GPU-aided calculations and easy parallelization. Both numerical and optical reconstructions are conducted. The results indicate that the presented algorithms compute diffraction patterns that provide successful photorealistic reconstructions; the computation times are acceptable especially on the GPU implementations.
Innovative In Vitro Chemo-Hormonal Drug Therapy for Refractory Thyroid Carcinomas (2012)

More than 95% of the thyroid carcinomas are well differentiated types showing favorable prognosis. However, only a few therapeutic options are available to treat the patients with undifferentiated thyroid carcinomas, especially with refractory thyroid carcinomas that are not amenable to surgery or radioiodine ablation. We investigated the anticancer effects of 20 chemotherapy and hormonal therapy drugs on 8 thyroid carcinoma cell lines. In vitro chemosensitivity was tested using the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA). The tumor inhibition rate (TIR; or cell death rate) or half maximal inhibitory concentration (IC(50)) was analyzed to interpret the results. Of the 12 chemotherapy drugs, etoposide (178.9 index value in follicular carcinoma cell line) and vincristine (211.7 in Hürthle cell carcinoma cell line) were the most active drugs showing the highest chemosensitivity, and of the 8 additional drugs, trichostatin A (0.03 µg/mL IC(50) in follicular carcinoma cell line) showed favorable outcome having the anticancer effect. In our study, the result of etoposide and vincristine show evidence as active anticancer drugs in thyroid carcinoma cell lines and trichostatin A seems be the next promising drug. These drugs may become an innovative therapy for refractory thyroid carcinomas in near future.
Genome‐level and biochemical diversity of the acyl‐activating enzyme superfamily in plants (2011)

Summary In higher plants, the superfamily of carboxyl‐CoA ligases and related proteins, collectively called acyl activating enzymes (AAEs), has evolved to provide enzymes for many pathways of primary and secondary metabolism and for the conjugation of hormones to amino acids. Across the superfamily there is only limited sequence similarity, but a series of highly conserved motifs, including the AMP‐binding domain, make it easy to identify members. These conserved motifs are best understood in terms of the unique domain‐rotation architecture that allows AAE enzymes to catalyze the two distinct steps of the CoA ligase reaction. Arabidopsis AAE sequences were used to identify the AAE gene families in the sequenced genomes of green algae, mosses, and trees; the size of the respective families increased with increasing degree of organismal cellular complexity, size, and generation time. Large‐scale genome duplications and small‐scale tandem gene duplications have contributed to AAE gene family complexity to differing extents in each of the multicellular species analyzed. Gene duplication and evolution of novel functions in Arabidopsis appears to have occurred rapidly, because acquisition of new substrate specificity is relatively easy in this class of proteins. Convergent evolution has also occurred between members of distantly related clades. These features of the AAE superfamily make it difficult to use homology searches and other genomics tools to predict enzyme function.
Same-segment and adjacent-segment disease following posterior cervical foraminotomy (2007)

Although additional study is needed, analysis of the present data suggests that posterior foraminotomy is associated with a low rate of same- and adjacent-segment disease.
Cell nanosurgery using ultrashort (femtosecond) laser pulses: Applications to membrane surgery and cell isolation (2005)

Membrane surgery and nanosurgical cell isolation using high-intensity femtosecond laser pulses is reported. We demonstrate the applicability of using ultrashort (femtosecond) laser pulses for performing surgery on live mammalian cells. When sub-10 femtosecond pulses were focused onto the cell, precise sub-micron surgical cuts were made on the biological membrane. Traversing the cells relative to the focused laser spot, we report on localized nanosurgical ablation of focal adhesion adjoining epithelial cells. In each study, the surgery was conducted without morphologically compromising the cells.
ZF 5-Speed Transmissions for Passenger Cars (1997)

&lt;div class="htmlview paragraph"&gt;With the introduction of the 5HP24 in early 1996, ZF has completed their product line for 5-speed transmissions. This transmission was especially developed for 8 cylinder engines and has achieved important improvements in fuel consumption, performance, comfort and reliability. This report shows, that 5-speed automatic transmissions result in a reduced fuel consumption, even in countries with speed limits. For example the 5HP24 incorporates the latest developments such as:&lt;/div&gt; &lt;div class="htmlview paragraph"&gt; &lt;ul class="list disc"&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;converter wirth controlled slip clutch (CSC)&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;measures to allow engine speed between 600 and 7200 rpm&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;modern closed loop control shifting strategy&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;performance improved Transmission Control Unit (TCU)&lt;/div&gt;&lt;/li&gt; &lt;/ul&gt; &lt;/div&gt;
Orthotopic Transplantation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Alveolar Progenitor Cells into Murine Lungs (2020)

ABSTRACT Humanized mice possessing human cells, tissues, or organ systems provide an unparalleled platform for preclinical studies in oncology, immunology, and infectious diseases. While the lungs are a vital organ subject to a wide variety of pathologies, exemplified by the ongoing COVID-19 pandemic, discrete differences in murine and human lungs can obfuscate interpretation of murine models of lung disease. Here we provide proof-of-concept methodology for the potential humanization of murine lungs via orthotopic transplantation of human NKX2.1+ progenitor cells and alveolar type 2 cells derived from induced pluripotent stem cells. We show that these cells engraft readily into highly immunocompromised mice after pharmacological injury with bleomycin, which presumably generates “space” for human cells to access denuded basement membrane and engraft. Transplanted cells stably retain their pulmonary lineage restriction and persist as superficially differentiated alveolar type 2 and type 1 cells. Future work should focus on strategies to promote xenorepopulation of most / all of the murine lung with human cells while retaining appropriate regio-specific epithelial differentiation and normal physiological function.
Boosting-Based Distributed and Adaptive Security-Monitoring through Agent Collaboration (2007)

The use of mobile agents to support the development of practical applications is limited primarily by the risks to which hosts in the system are subject to. This article introduces a distributed and adaptive security-monitoring framework to decrease such potential threats. The proposed framework is based on a modified version of the popular Boosting algorithm to classify malicious agents based on their execution patterns on current and prior hosts. Having implemented the framework for the Aglet platform, we herein present the results of our experiments showcasing the detection of agent entities in the system with intention deviating from that of their well-behaved counterparts.
Phase relation between supercooled liquid and amorphous silicon (2020)

The phase relation between supercooled liquid silicon (l-Si) and amorphous silicon (a-Si) is discussed based on experimental results. Electrostatically levitated l-Si samples were supercooled down to low temperatures, 300 K below the melting temperature (Tcl: 1683 K), and solidified accompanied by the release of latent heat. It was found that solidified Si samples melted again at 1480 K caused by the latent heat. Also, it was found that the Si samples that rapidly quenched near the solidification temperature contained a large amount of a-Si with tetrahedral coordination. These two findings show that the supercooled l-Si samples solidified into a-Si and a-Si melted, confirming the idea of a first-order phase transition between two metastable phases proposed by Turnbull et al. [Metall. Mater. Trans. A 29, 1825 (1998)].
Reevaluation of the use of peroxycamphoric acid as an asymmetric oxidizing agent (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReevaluation of the use of peroxycamphoric acid as an asymmetric oxidizing agentW. H. Pirkle and P. L. RinaldiCite this: J. Org. Chem. 1977, 42, 12, 2080–2082Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/jo00432a009https://doi.org/10.1021/jo00432a009research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of technetium-99m–labeled colloid albumin for preoperative and intraoperative localization of nonpalpable breast lesions1 (2000)

Radioguided occult lesion localization seems to offer a simple and reliable method to locate occult breast lesions with a gamma-detecting probe, allowing complete removal of the lesion in 99.5% of patients. Because of the small quantity of radioactivity, the procedure is safe for both patients and medical staff.
Maf1 regulation (2010)

RNA polymerase III (Pol III) is responsible for the synthesis of 5S ribosomal RNA (rRNA) and transfer RNAs (tRNAs) essential for protein synthesis and cell growth. Pol III is tightly controlled by growth signals such as nutrients and deregulation of Pol III-dependent transcription can lead to oncogenic transformation. In response to extracellular stimuli, the target of rapamycin complex 1 (TORC1) regulates Pol III activity through Maf1, a key conserved Pol III repressor. Recent studies have unraveled intricate mechanisms by which Maf1 activity is controlled at multiple levels, including nuclear transport and phoshorylation at specific chromatin loci. These studies suggest an emerging mode of gene regulation by extracellular signals inside the nucleus.
ChemInform Abstract: Synthesis of Sterically Congested Polycyclic Aromatic Hydrocarbons: Rhodium(III)‐Catalyzed Cascade Oxidative Annulation of Aryl Ketoximes with Diphenylacetylene by Sequential Cleavage of Multiple C—H Bonds. (2015)

Abstract The scalable protocol for the synthesis of title compounds tolerates various functional groups.
Enhanced single-phase heat transfer for ocean thermal energy conversion systems. Final report (1977)

Preliminary studies have shown that the heat exchanger costs for an Ocean Thermal Energy Conversion (OTEC) system represent approximately one-half of the total capital cost. Much of the OTEC research is now directed at development of lower cost heat exchangers which are not unduly affected by biofouling. It appears that reduced size (and cost) will require utilization of enhanced heat transfer surfaces for both the boiler and the condenser. An initial study directed toward assessing the potential for heat transfer enhancement of the sea water, or single-phase side, of these heat exchangers is described. Single-phase, forced convection heat transfer can be enhanced by a wide variety of techniques. Of primary interest in large-scale heat exchange equipment are a number of ''passive'' techniques which do not require external power to generate and sustain the improvement. These techniques are: rough surfaces, extended surfaces, displaced enhancement devices, and swirl flow devices. As part of this study the world literature was surveyed to locate representative data for these techniques. A computer search of an extensive collection of general literature on heat transfer enhancement was utilized. Heat transfer and friction factor data are presented for various techniques and subgroups of techniques, particularly those data whichmore » demonstrate the maximum reported improvements in heat transfer coefficients.« less
Low-volume hybrid tap-connected SC-buck converter with shared output capacitor (2017)

This paper introduces a hybrid converter topology for low-power applications that uses a novel connection of a switched capacitor (SC) converter and a buck converter to achieve smaller volume and better power processing efficiency than conventional step-down solutions. Specific advantages of this topology include smaller inductor volume, reduced input filter requirements, and lower voltages stress of the semiconductor components. These advantages are achieved by connecting the buck converter to a tap of a 2:1 ladder SC circuit and both stages share the middle capacitor of the capacitor stack. A direct connection of the stacked input capacitors of the SC to the source acts as a portion of the input filter and reduces the voltage swing across the inductor and switching components, allowing for smaller inductance value and lower voltage stress. The advantages of this topology are verified with a digitally controlled 24 V to 5 V/ 5 A, 1 MHz experimental prototype having about 50% smaller inductor, and about 30% lower voltage stress than a conventional buck converter.
A cellular 57 kDa protein binds to two regions of the internal translation initiation site of foot‐and‐mouth disease virus (1990)

A ribosome-associated 57 kDa protein from rabbit reticulocytes was linked to the internal translation initiation site of foot-and-mouth disease virus by mild UV-irradiation. Binding studies with different RNA fragments revealed that this protein interacts with two distinct sites within the translational control region. One site is located approximately 400 nucleotides upstream from the translational start codon and the second binding site could be confined to 60 nucleotides preceding this codon. Both sequences coincide with hairpin structures at the two opposite ends of a secondary structure model of the internal ribosomal entry site proposed by Pilipenko et al. [(1989) Nucleic Acids Res. 17, 5701-5711].
Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors (2017)

A series of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazol derivatives were designed as potential microtubule targeting agents. The regioselective alkylation of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole was predicted by computations and confirmed by an unambiguous synthetic route. The antiproliferative activity of the synthesized compounds was tested in vitro using three human cancer cell lines and some compounds exhibited significant antiproliferative activity, which suggested the reasonability of introduction of the 1,2,3-triazole fragment. Among them, compound 7p showed highest activity with the IC<sub>50</sub> values at nanomolar level towards all three cell lines, which were comparable to the positive control, CA-4. Tubulin polymerization assay, immunofluorescence studies, cell cycle analysis and competitive tubulin-binding assay strongly proved that 7p is a colchicine binding site inhibitor of tubulin. Thus, 7p was identified as a promising drug candidate for further development of colchicine binding site inhibitors.
Effective IT Project Leadership (2020)

Effective project leadership, which goes beyond traditional project management, is essential for successfully deploying IT initiatives that are often overwhelmed with increasing levels of technology and business integration complexity. We identify five distinct project leadership types (Administrator, Technologist, Business Integration Lead, Principal Lead, and Consummate Lead) that can be matched to projects with different complexity levels. Together with the corresponding transformational and transactional behaviors essential for leaders, these five types provide a framework for effective project leadership.
Uncoupled glycerol distribution as the origin of the accumulation of 3-hydroxypropionaldehyde during the fermentation of glycerol by Enterobacter agglomerans CNCM 1210 (1998)

2 graph.