gebhart/patrepeval huggingface dataset:
442 Reversible Cognitive Dysfunction and Neuropsychiatric Symptoms in Patients With Chiari Malformation Type I (2023)

INTRODUCTION: Chiari malformation type I (CMI) is a congenital/acquired structural condition where the cerebellar tonsils herniate through the foramen magnum, resulting in cerebellar and lower medulla/upper cervical spinal cord compression. Symptoms typically include occipital headaches, however, additional symptoms have been reported by symptomatic patients. We have observed a proportion reporting cognitive dysfunction and neuropsychiatric symptoms, which appear to improve following posterior fossa decompression (PFD). METHODS: Patients completed comprehensive neuropsychological evaluations, including a 90-minute standardized assessment of cognitive function across multiple domains and a self-reported assessment of neuropsychiatric symptoms, pre- and approximately 6-months post-surgery. RESULTS: This prospective study included patients with CMI who opted to undergo PFD surgery and reported cognitive or neuropsychiatric impairment between 2015 to 2021. All patients completed a comprehensive pre-operative neuropsychological assessment. A parallel assessment was completed at 6-month post-operative follow-up. 112 patients (Mage = 35.1 years; SD = 10.4) were included in pre-operative analyses, and of these, 31 patients (Mage = 32.5 years; SD = 10.5) were included in paired pre-post-operative analyses. Pre-operatively, CMI patients performed significantly worse than a standard norm on measures of executive function, attention, visuospatial memory, verbal memory, and neuropsychiatric symptoms. CONCLUSIONS: This is the first study to 1) demonstrate significant impairments in cognitive function and neuropsychiatric symptoms in CMI patients pre-operatively, and 2) show significant improvements in these domains at post-operative follow-up. This work calls attention to a significant proportion of CMI patients who suffer debilitating and life altering symptoms and provides compelling evidence for a role of the cerebellum in such conditions. In addition to CMI, cerebellar pathology should be considered as potential neuroanatomical site for patients with cognitive and neuropsychiatric impairment from other etiologies.
Étude de l'enlèvement du Cd, Cu, Mn et Zn par solubilisation biologique dans les sédiments lacustres fortement contaminés (2005)

Des essais en erlenmeyers de 0,5 L ont été faits afin d'évaluer les possibilités d'application d'un procédé de solubilisation biologique aux sédiments. Ce procédé utilise la capacité des thiobacilles de lixivier les métaux en milieu acide. Au cours des essais, l'influence, sur la solubilisation des métaux, de la quantité de substrat (FeSO4 × 7H2O), du pourcentage d'inoculum et de la teneur en solides totaux a été suivie. La concentration de substrat n'a pas d'effet sur l'enlèvement du Cd, du Zn, du Mn et du Cu. Les taux d'enlèvement moyens pour le Cd, Zn et Mn, sont, après 46 heures, de 70 à 90 %, 90 à 100 % et 64 à 72 % pour des concentrations de substrat variant de 0 à 30 % FeSO4 × 7H2O (poids sec/poids sec). A 29 et 46 heures, des coefficients de détermination (r 2 ) de 0,46 et 0,59 entre le pH et la concentration de FeSO4 × 7H2O, et de 0,92 et 0,55 entre le POR et la concentration de FeSO4 × 7H2O ont été trouvés. A plus forte teneur en FeSO4 × 7H2O, le POR est moins élevé, surtout au début des essais. La présence des ions ferreux en plus grande quantité expliquerait les plus faibles valeurs du potentiel-rédox. A 20 % d'inoculum, la solubilisation des métaux est optimale avec une solubili- sation de 86 % pour le Cd et 73 % pour le Cu et le Mn. La forte corrélation entre le POR, le pH et le pourcentage d'inoculum (r 2 à 29, 46 et 70 heures de 0,94, 0,94 et 0,63 pour le POR et le pourcentage d'inoculum et de 0,80, 0,69 et 0,60 pour le pH et le pourcentage d'inoculum), a permis d'établir une corrélation entre le POR, le pH et la solubilisation du Cu. Les seuils trouvés permettant une solubilisation du Cu supérieure à 10 % sont un pH de 3,75 et un POR de 260 mV. L'augmentation des solides totaux (ST) semble limiter le développement des thiobacilles et diminue les rendements de solubilisation du Cd (à 21 heures) et du Zn (à 45 heures). Ainsi, pour le Cd, les pourcentages de solubilisation passent de 71 % à 24 % pour 3 et 15 % ST, alors que dans le cas du Zn, ils diminuent de 94 % à 81 % pour 3 et 15 % ST. La solubilisation du Mn serait, pour sa part, plutôt de type chimique.
Target-assisted FRET signal amplification for ultrasensitive detection of microRNA (2019)

MicroRNA (miRNA) is a type of noncoding RNA and plays a crucial role in gene expression regulation. Sensitive identification and detection of miRNA can offer vast information for transcriptome analysis and cancer studies. Conventional PCR and molecular hybridization techniques suffer from low specificity when used for miRNA detection due to the short nucleotide length of miRNA. The extremely low abundance of miRNA in real biological samples also sets higher demands for the sensitivity of detection methods. A novel method based on target-assisted fluorescence resonance energy transfer (FRET) signal amplification was proposed for the simple and ultrasensitive detection of miRNA. A hairpin fluorescence DNA probe could hybridize with target miRNA to expose the hybridization site for the primer. After being duplexed with the nanogold-labeled primer, the fluorescent dye in the DNA probe was quenched via the FRET mechanism. In the presence of a DNA polymerase, primer-activated strand displacement released the miRNA, and then the miRNA strand could recognize and function with another DNA probe. The recycling of target miRNA and a high quenching efficiency of nanogold greatly improved the sensitivity. The detection limit of the method (1.5 fM) was lower than that of the reported strategies using a target cycling reaction, allowing trace detection of miRNA in real samples. By making full use of miRNA sequences, the method could also recognize single-base mismatches and distinguish homologous miRNAs.
Effects of Extracorporeal Shockwave Therapy on Improvements in Lymphedema, Quality of Life, and Fibrous Tissue in Breast Cancer-Related Lymphedema (2020)

ESWT reduced edema and skin fibrosis without significant complications. Therefore, ESWT can be used together with complex decongestive physical therapy for treating lymphedema.
A Decomposition Approach for Discovering Discriminative Motifs in a Sequence Database (2014)

Considerable effort has been invested over the years in ad-hoc algorithms for item set and pattern mining. Constraint programming has recently been proposed as a means to tackle item set mining tasks within a general modelling framework. We follow this approach to address the discovery of discriminative n-ary motifs in databases of labeled sequences. We define a n-ary motif as a mapping of n patterns to n class-wide embeddings and we restrict the interpretation of constraints on a motif to the sequences embedding all patterns. We formulate core constraints that minimize redundancy between motifs and introduce a general constraint optimization framework to compute common and exclusive motifs. We cast the discovery of closed and replication-free motifs in this framework for which we propose a two-stage approach based on constraint programming. Experimental results on datasets of protein sequences demonstrate the efficiency of the approach.
SYNCHRONIZATION OF ELECTROENCEPHALOGRAPHY AND EYE TRACKING USING GLOBAL ILLUMINATION CHANGES (2014)

This paper describes a flexible method for synchronizing electroencephalography (EEG) and eye tracking (ET) recordings to the presentation of visual stimuli. The method consists of embedding a synchronization signal in the visual stimuli, and recording this signal with both the EEG and ET equipment. The signal is recorded by the EEG device as an additional data channel, and with the camera used in the ET equipment by modulating the global illumination of the scene in time with the synchronizing signal. The prototype system where this method was implemented resulted in a single sample of jitter in both the EEG and ET system, while the ET system achieved a spatial resolution of 1.26 degrees. The system will be used in future work with augmented memory applications.
Risk management and stable financial structures (1993)

National risk management and stable financial structures are essential to the long-term economic growth of developing coun-tries. The 1980s taught many nations the heavy cost of the financial distress associated with poor national and sectoral risk management. Policy RsaerchWoringPapers disemnatethefindings ofw,rkinpougsasand encouragethe xchangcofideas amongBar staff and al others int ed in developmanlissues. Thespapeas disurlbutedby theRescarchAdvisozy Staff carxy thenames oftheauthors, reflect only theirviews, andshouldbeused and ited accordingly.Toefindings, int rnetations.andconyusons arethe auxhoresown.Theyshould not be attributed, o the Wodid Bank, its Board of Diretors, its managemenat, or any of its member countries. Pu bl ic Di sc lo su re A ut ho riz ed Pu bl ic Di sc lo su re A ut ho riz ed Pu bl ic Di sc lo su re A ut ho riz ed Pu bl ic Di sc lo su re A ut ho riz ed
A Novel, Low-Cost, Reduced-Sensor Approach for Providing Smart Renote Monitoring and Diagnostics for Packaged Air Conditioners and Heat Pumps (2009)

This report describes conceptually an approach to providing automated remote performance and conditioning monitoring and fault detection for air conditioners and heat pumps that shows great promise to reduce the capital and installation costs of such systems from over $1000 per unit to $200 to $400 per unit. The approach relies on non-intrusive electric load monitoring (NIELM) to enable separation of the power use signals of compressors and fans in the air conditioner or heat pump. Then combining information on the power uses and one or two air temperature measurements, changes in energy efficiency and occurrence of major faults would be detected. By decreasing the number of sensors used from between ten and twenty in current diagnostic monitoring systems to three for the envisaged system, the capital cost of the monitoring system hardware and the cost of labor for installation would be decreased significantly. After describing the problem being addressed and the concept for performance monitoring and fault detection in more detail, the report identifies specific conditions and faults that the proposed method would detect, discusses specific needs for successful use of the NIELM approach, and identifies the major elements in the path from concept to a commercialized monitoring and diagnostic system.
Finding similar pages in a social tagging repository (2008)

Social tagging describes a community of users labeling web content with tags. It is a simple activity that enriches our knowledge about resources on the web. For a computer to help users search the tagged repository, it must know when tags are good or bad. We describe TagScore, a scoring function that rates the goodness of tags. The tags and their ratings give us a succinct synopsis for a page. We `find similar' pages in Del.icio.us by comparing synopses. Our approach gives good correlation to the full cosine similarity but is hundreds of times faster.
Design and Implementation of a Wireless OBD II Fleet Management System (2016)

This paper describes the work that has been done in the design and development of a wireless on-board diagnostic system (OBD II) fleet management system. The system aims to measure speed, distance, and fuel consumption of vehicles for tracking and analysis purposes. An OBD II reader is designed to measure speed and mass air flow, from which the distance and fuel consumption are also computed. This data is then transmitted via WiFi to a remote server. The system also implements global positioning system tracking to determine the location of the vehicle. A database management system is implemented at the remote server for the storage and management of transmitted data and a graphical user interface is developed for analysing the transmitted data. Various qualification tests are conducted to verify the functionality of the system. The results demonstrate that the system is capable of reading the various parameters, and can successfully process, transmit, and display the readings.
Abstract 1130: AKT-mediated phosphorylation is responsible for TWIST1-mediated tumor growth and metastasis (2014)

Abstract Cancer cells show epithelial-mesenchymal transition (EMT) during cell migration, invasion and dissemination. Although it has been shown by numerous publications that the evolutionary conserved basic helix-loop-helix (b-HLH) transcription factor TWIST1 plays pivotal role during EMT the molecular mechanism responsible for TWIST1 function is not fully understood. Here we show that Twist1 binds to and phosphorylated by AKT/protein kinase-B at S42, T121 and S123. While conversion of S42, T121 and S123 to phosphorylation-mimicking Aspartic or glutamic acids created active Twist1, Alanin mutants of the same sites diminished the DNA-binding and transctivating functions of Twist1. In line with this, Glutamic Acids mutants suppressed the expression of E-Cadherin, whose expression is negatively regulated by active TWIST1, Alanin mutants induced the expression of E-Cadherin. Similarly, we tested the impact of above mentioned mutants on cell migration and proliferation. Our results demonstrated that while Glutamic acid mutants accelerated, Alanin mutants suppressed the migration and proliferation of 293T cells. Our in vitro results prompted us to test our mutants under in vivo conditions using breast cancer as a model. We transfected non-metastatic mouse mammary tumor cell line, 67NR, with Glutamic acid mutants, and metastatic mouse mammary tumor cell line, 4T1, with Alanin mutants of mouse TWIST1 and selected the Neo-resistant populations. We injected 1 million 67NR cells over-expressing wild type or Glutamic acid mutants of Twist1, and 100.000 4T1 cells over-expressing wild type or Alanin mutants of Twist1 into the breast tissue of female inbred BalBC mice, and animals were monitored for metastasis. At the end of the 4th week, we sacrifised and examined the animals for tumor growth and metastasis. Although 67NR cells over-expressing wild type Twist1 did not show any metastasis, cells over-expressing 1E (S42E) and 2E (S42E, T121E) mutants of Twist1 showed 15-20 macroscopic metastasis to liver and Lungs. Paralel to this, 4T1 cells expressing 1A (S42A) and 2A (S42A, T121A) mutants of TWIST1 showed no macroscopic metastasis. Our results clearly indicate that phosphorylation of S42 and T121 by AKT is essential for TWIST1-mediated tumor growth and metastasis. Citation Format: Osman N. Ozes, Suray Pehivanoglu, Gokhan Ertosun, Gokhan Gorgisen, Nuray Erin, Duygu Unal, Gamze Tanriover. AKT-mediated phosphorylation is responsible for TWIST1-mediated tumor growth and metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1130. doi:10.1158/1538-7445.AM2014-1130
Effect of solvent types on structure and performance of polyethersulfone nanofiltration membrane in monovalent and divalent ions separation (2005)

membrane produced using NMP as the solvent followed by DMAc and lastly, DMF. This study indicated that solvent with higher boiling point (in this study, NMP has the highest boiling point) produced a desired NF in embrane with more finger-like structure. The diameters of pores in skin layer were measured by Steric-Hindrance Pore (SHP) and Teorell-Meyer-Sievers (TMS) model. The mean pore size of each produced membrane was about 1.28 ring 1.47 nm and 1.59 nm for AWP, DMAc and DMF respectively. The performances of the PES nanofiltration membranes were examined based an rejection and flux. Generally, the rejections of mono and divalent anions were identified to be within 29%-38%, and 81%-91% respectively. As predicted by the morphological structure, NMP solvent-membrane showed the best salt rejection for both monovalent and divalent ions as compared to DMAc and DMF. Hence, solvent was discovered to affect the morphological structure and consequently, improved the performance of the polyethersulfone nanofiltration membrane.
Surface Technology with Cold Microplasmas (2007)

Abstract Various new plasma‐based surface technological processes are made feasible by localizing atmospheric‐pressure discharges to predefined volumes with sub‐millimeter linear dimensions. So‐called Plasma Printing processes use cold discharges in microcavities formed temporarily by contacting a substrate with a suitably designed kind of plasma stamp. Aside from dielectric barrier discharges driven by mid‐frequency (MF) AC voltages, cold microplasmas can also be sustained in arrangements without a dielectric barrier, if RF excitation is used. The modification or coating of internal surfaces in already sealed microfluidic systems promises the achievement of a wide range of physico‐chemical surface properties which are difficult to attain by wet‐chemical or low‐pressure plasma processes. Using a proper electrode arrangement, the coating or modification can be localized to a selected segment of a microfluidic system. magnified image
Mapping of loci from Solanum lycopersicoides conferring resistance or susceptibility to Botrytis cinerea in tomato (2009)

Cultivated tomato (Solanum lycopersicum, syn. Lycopersicon esculentum) is susceptible to the necrotrophic ascomycete and causal agent of gray mold, Botrytis cinerea. Resistance to this fungal pathogen is elevated in wild relatives of tomato, including Solanum lycopersicoides. An introgression line population (IL) containing chromosomal segments of S. lycopersicoides within the background of tomato cv. VF36 was used to screen the genome for foliar resistance and susceptibility to B. cinerea. Based on this screen, putative quantitative trait loci (QTL) were identified, five for resistance and two for susceptibility. Four resistance QTL decreased infection frequency while the fifth reduced lesion diameter. One susceptibility QTL increased infection frequency whereas the other increased lesion diameter. Overlapping chromosomal segments provided strong evidence for partial resistance on chromosomes 1 and 9 and for elevated susceptibility on chromosome 11. Segregation analysis confirmed the major resistance QTL on the long arm of chromosome 1 and susceptibility on chromosome 11. Linkage of partial resistance to chromosome 9 could not be confirmed. The usefulness of these data for resistance breeding and for map-based cloning of foliar resistance to B. cinerea is discussed.
Photovoltaic Inverters with Perturb & Observe MPPT Technique and One-Cycle Control (2006)

This work presents a single-stage photovoltaic inverter which is based on one-cycle control. Such an inverter is characterized by two original features. The first one lies in a new formulation of the set of equations for the design of the one-cycle control circuitry of the inverter, such constraints are explained in L. Egiziano et al. (2006) and are here used to select the optimal solution. The second original characteristic of the proposed inverter lies in the development of a Perturb&Observe maximum power point tracking technique customized for a one cycle controlled single-stage inverter (patent pending) based on a sub set of the constraints reported in L. Egiziano et al. (2006). The results obtained show that the performances of the proposed system are top level and that the proposed solution represents the first true single stage photovoltaic inverter
Identification and Characterization of Two New S-Adenosylmethionine-Dependent Methyltransferase Encoding Genes Suggested Their Involvement in Stipe Elongation of Flammulina velutipes (2019)

Two new SAM-dependent methyltransferase encoding genes (fvsmt1 and fvsmt2) were identified from the genome of Flammulina velutipes. In order to make a comprehensive characterization of both genes, we performed in silico analysis of both genes and used qRT-PCR to reveal their expression patterns during the development of F. velutipes. There are 4 and 6 exons with total length of 693 and 978 bp in fvsmt2 and fvsmt1, respectively. The deduced proteins, i.e., FVSMT1 and FVSMT2 contained 325 and 230 amino acids with molecular weight 36297 and 24894 Da, respectively. Both proteins contained a SAM-dependent catalytic domain with signature motifs (I, p-I, II, and III) defining the SAM fold. SAM-dependent catalytic domain is located either in the middle or at the N-terminal of FVSMT2 and FVSMT1, respectively. Alignment and phylogenic analysis showed that FVSMT1 is a homolog to a protein–arginine omega-N-methyltransferase, while FVSMT2 is of cinnamoyl CoA O-methyltransferase type and predicted subcellular locations of these proteins are mitochondria and cytoplasm, respectively. qRT-PCR showed that fvsmt1 and fvsmt2 expression was regulated in different developmental stages. The maximum expression levels of fvsmt1 and fvsmt2 were observed in stipe elongation, while no difference was found in mycelium and pileus. These results positively demonstrate that both the methyltransferase encoding genes are involved in the stipe elongation of F. velutipes.
Reversible Insertion of Carbon Dioxide at Phosphine Sulfonamido PdII–Aryl Complexes (2020)

Phosphine sulfonamido Pd(II) complexes bearing p-anisyl ([(P,N)Pd(4-OMe-C6H4)L]; L = C5H5N, 5-py; L = OS(CH3)2, 5-dmso) or carboxylato ([(P,N)Pd(OOCR)], 1-X: R = 4-OMe-C6H4, 1-pAn; R = tBu, 1-Piv; R = C6H5, 1-Ph) ligands were synthesized and their structures and dynamic behaviors were characterized. The compound 5-dmso can effectively be converted to 1-pAn by migratory insertion of carbon dioxide into the Pd–aryl bond with precoordination of the CO2 molecule. Additionally, carboxylato-substituted compounds 1-X can serve as catalysts for protodecarboxylation reactions of bis-o-OMe-substituted carboxylic acids at room temperature without the need for an external proton source. Stoichiometric decarboxylative coupling of these acids with styrene selectively yields 1,1-diarylated olefins.