gebhart/patrepeval huggingface dataset:
The Effects of Halothane and Cyclopropane on Total Pulmonary Resistance in the Dog (1969)

The authors compared the effects of halothane and cyclopropane on total pulmonary resistance (RL) in dogs before (unstimulated) and during airway constriction produced by histamine or vagal nerve stimulation. In two dogs, direct measurements of airway diameter were obtained from bronchograms and com
The Politics of Competitive Tendering: Political Orientation and Attitudes towards Contracting Out among Finnish Local Politicians (2010)

Abstract Using survey data on Finnish local politicians (n = 364) we examine the extent to which political orientation affects attitudes towards and perceptions of competitive tendering in social and health service provision. Expectation of cost benefits turns out to be the most important factor accounting for willingness to increase the usage of competitive tendering. The perceived positive impact of tendering on local democracy is also related to local politicians' readiness to implement reforms. However, political orientation does have a strong effect on politicians' perceptions. We also consider whether there are mitigating factors that could mask the relationship between political orientation and attitudes towards tendering. We identify one such factor, municipal employment: public-sector employees form a kind of informal ‘interest group’ resisting public-sector reforms in municipal decision making. In general, our results suggest that macro-level studies on competitive tendering underestimate the effects of political ideology on local decision making.
Impairment of Coronary Blood Flow Regulation by Endothelium-Derived Nitric Oxide in Dogs with Alloxan-Induced Diabetes (1996)

Diabetes mellitus is a major cause of ischemic coronary artery disease. Endothelial dysfunction is implicated in the pathogenesis of diabetic vascular disease. To examine coronary blood flow (CBF) regulation with endothelium-derived nitric oxide (EDNO) in the diabetic state, we compared the effects of both acetylcholine (ACh) and adenosine (Ado) on left circumflex coronary artery (LCX) blood flow in 12 vehicle-treated and 21 dogs made diabetic with alloxan anesthetized with pentobarbital. All dogs were pretreated with aspirin to inhibit endogenous prostaglandins. None of the hemodynamic parameters were significantly different in the two groups. The percent change in coronary vascular resistance (CVR) after ACh (100 ng/kg) infusion was significantly attenuated in diabetic dogs (-56.5 +/- 1.4%) as compared with vehicle-treated dogs (-64.5 +/- 1.2%) (p < 0.01), whereas the effect of Ado (1 microgram/kg) was not different between the two groups (-71.1 +/- 1.5% in vehicle, -67.0 +/- 1.3% in diabetes). After infusion of incremental doses of NG-nitro-L-arginine methyl ester (L-NAME) 10(-5)-10(-3)M, the effect of ACh was progressively inhibited in both groups and was different no longer between the two groups after the maximal dose. L-Arginine (L-ARG), but not D-ARG, significantly restored the effect of ACh in diabetic dogs but did not affect vehicle-treated dogs. The effect of Ado did not change after L- and D-ARG administration. Cu, Zn-superoxide dismutase (Cu, Zn-SOD) had no effect on any of the effects of ACh and Ado in diabetic dogs. Regulation of CBF with EDNO is impaired in dogs with alloxan-induced diabetes, and this impairment is partially restored by L-ARG.
Selecting vantage objects for similarity indexing (2006)

To make similarity searching in multimedia databases practical, indexing has become a necessity. Vantage indexing is an indexing technique which maps a dissimilarity space onto a vector space such that each object is represented by a vector of dissimilarities to a small set of m reference objects, the vantage objects. Querying takes place within this vector space, reducing the number of distance calculations to m. The retrieval performance of a system based on this technique can be improved significantly through a proper choice of vantage objects. We propose a new technique for selecting vantage objects and present experimental results based on data sets of different modality.
Does the Public Sector HRM System Strengthen Staff Performance? (2012)

An important objective of any Human Resource Management (HRM) system in Government is to motivate staff to perform well. This GET note looks at several HRM levers that Governments have at their disposal to influence staff performance. In particular, some of the most common levers in the public sector include: effective recruitment and retention of staff; strong staff engagement in the organization’s mission; well-designed incentives for staff to perform as well as ‘opportunities to perform’; tailored training and capacity building; and high quality performance dialogues with staff and effective follow up. In designing a HRM system that utilizes these levers effectively, this GET Note shows that it is more important to diagnose the root cause and understand the major issues of poor performance, before proposing reform actions. This paper proposes three important design questions for managers of HRM systems to assess whether they have a well-designed HRM system. 1) Does the HRM system provide both ‘external incentives’ and ‘opportunities to perform’? Does the HRM system provide the right balance between short and long term incentives? And are the broader, supporting aspects of the HRM system working effectively? The note concludes by highlighting that even where the HRM system is well designed, careful consideration must be given to two further aspects: a) how to implement reforms to improve the design of the HRM system, and b) how to ensure that a well-designed HRM system is operating effectively.
Compact Via-Coupling Fed Monopulse Antenna With Orthogonal Tracking Capability in Radiation Pattern (2020)

In this letter, a compact monopulse antenna operating at 10 GHz is presented. The feed network consists of four rat-race couplers, which generate sum and difference patterns in orthogonal radiation planes (azimuth and elevation). The focus is on improving the performance by improving the matching circuit to generate in-phase and out-phase excitations while also maintaining a very high null-depth, which is applicable for tracking purposes. The electromagnetic energy is transmitted from the feed network to the radiators through the via-coupling structure. Using the symmetrical via-fed patch array results in the low-mutual coupling between the antenna ports. A prototype of the proposed antenna is manufactured on a printed circuit board and is tested. A suitable agreement between the measurement and simulation results is obtained. The results show a -10 dB impedance bandwidth of 2.1%, as well as -24 and -20 dB null depths on the elevation and azimuth planes, respectively, in the difference mode of operation.
Determination of elemental composition of coffee using UV-pulsed laser induced breakdown spectroscopy (2016)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. A. Gondal, Umair Baig, M. A. Dastageer, Mohsin Sarwar; Determination of elemental composition of coffee using UV-pulsed laser induced breakdown spectroscopy. AIP Conf. Proc. 10 June 2016; 1742 (1): 030007. https://doi.org/10.1063/1.4953128 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
On the reliability and additional overhead of reliable on-demand multicast routing protocol for mobile Ad hoc networks (2004)

Multicasting is the transmission of datagrams to a group of hosts identified by a single destination address, providing simple and efficient communication for group-oriented applications. Many applications currently envisioned for mobile ad hoc networks require multicasting. Several multicasting protocols have been proposed for mobile ad hoc networks, one of the most popular being the On Demand Multicast Routing Protocol. This paper provides a review of ad hoc multicast routing protocols, focusing on MAODV, ODMRP and a variation of ODMRP called reliable-ODMRP. NS-2 simulations are used to compare the reliability and overhead of MAODV, ODMRP, and R-ODMRP.
Concise Synthesis of an Amide-Functionalized [7]Helicene-like Molecule via Intramolecular Amidation (2021)

Crystal structure of (dl)-5 S-2 Computational details for an estimation of the racemization barrier of 5 S-3 Crystal structure of (dl)-5 (full disordered structure, 50% probability) Crystallographic data for the single crystal of (dl)-5 obtained by recrystallization from n-hexanetoluene: C29H17NO, M = 395.43,monoclinic, P21, a = 9.0465(2), b = 11.3071(3),c = 19.1900(5)Å, a = 90°, b = 95.411(2)°,g = 90°, V = 1954.19(8)Å 3 , Z = 4, rcalcd = 1.317 gcm -3 , T = 103 K, 22156 reflections measured, 7194 unique.The final R1 and wR were 0.0587 and 0.1787 (all data).These data have been deposited with the Cambridge Crystallographic Data Center as CCDC 2031916. Computational details for an estimation of the racemization barrier of 5Density functional theory (DFT) calculations were performed using the Gaussian 16 software package. 1)The molecular geometries for the transition states (TS) were first estimated with the Reaction plus software package, based on the nudged elastic band method, 2) and were
Physical activity and sleep profiles in Finnish men and women (2014)

Physical activity (PA) and sleep are related to cardiovascular diseases (CVD) and their risk factors. The interrelationship between these behaviors has been studied, but there remain questions regarding the association of different types of PA, such as occupational, commuting, and leisure time to sleep, including quality, duration and sufficiency. It is also unclear to what extent sleep affects peoples’ PA levels and patterns. Our aim is to investigate the interrelationship between PA and sleep behaviors in the Finnish population, including employment status and gender. The study comprised population based data from the FINRISK 2012 Study. A stratified, random sample of 10,000 Finns, 25 to 74 years-old, were sent a questionnaire and an invitation to a health examination. The participation rate was 64% (n = 6,414). Latent class analysis was used to search for different underlying profiles of PA and sleep behavior in men and women, respectively. Models with one through five latent profiles were fitted to the data. Based on fit indicators, a four-class model for men and women, respectively, was decided to be the best fitted model. Four different profiles of PA and sleep were found in both men and women. The most common profile of men comprised 45% of the total participants, and in women, 47%. These profiles were distinguished by probabilities for high leisure time PA and sleep, subjectively rated as sufficient, as well as sleep duration of 7–7.9 hours. The least common profiles represented 5% (men) and 11% (women) of the population, and were characterized by probabilities for physical inactivity, short sleep, and evening type for women and morning type for men. There was also one profile in both genders characterized by likelihood for both high occupational PA and subjectively experienced insufficient sleep. The use of latent class analysis in investigating the interrelationship between PA and sleep is a novel perspective. The method provides information on the clustering of behaviors in people and the profiles found suggest an accumulative nature of leisure time PA, and better sleep. Our data also suggest that high levels of occupational PA are associated with shorter and poorer sleep.
A very rare case of primary meningococcal arthritis in an adult male (2014)

We report here a very rare case of primary meningococcal arthritis of the knee joint without clinical features associated with meningococcemia, meningitis, or meningococcal complications. The patient suffered from diabetes mellitus and had experienced two episodes of joint trauma. Intravenous infusion of ampicillin/sulbactam for 18 consecutive days was successful.
Hard x-ray phase contrast imaging using a tabletop Talbot–Lau interferometer with multiline embedded x-ray targets (2013)

We demonstrate hard x-ray phase contrast imaging (XPCI) using a tabletop Talbot-Lau interferometer in which the x-ray source and source grating are replaced with an x-ray source with multiline metal targets embedded in a diamond substrate. This source realizes an array of linear x-ray sources of a few micrometers width without fabrication difficulty because of the shallow penetration depth of electrons irradiated to the metal targets. This enhances the coherence of x rays from each linear source and allows XPCI within 45 cm source-detector distance under 1.2 W input power for 8 keV x rays.
Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells (2000)

The RON receptor tyrosine kinase is a 180 kDa heterodimeric protein composed of a 40 kDa alpha chain and a 145 kDa beta chain with intrinsic tyrosine kinase activity. Activation of RON causes cell dissociation, motility and invasion of extracellular matrices, suggesting that RON might be involved in tumor metastasis. We report here the cloning of a novel splice variant of RON in human colorectal carcinoma cell line HT-29. This RON variant is first produced as a single chain precursor with a molecular mass of 160 kDa. Proteolytic cleavage results in a 40 kDa alpha chain and a short form of the beta chain with a molecular mass of 125 kDa. The altered receptor is synthesized from a transcript differing from the full-length RON mRNA by an in-frame deletion of 109 amino acids in the extracellular domain of the RON beta chain. The consequence of the deletion is constitutive activation of the protein with autophosphorylation. Expression of the RON variant in colon epithelial CoTr cells results in increased cell migration and invasion of extracellular matrices. These data suggest that generation of the activated splice variant of RON may contribute to the invasive phenotype of human colorectal carcinomas in vivo.
Optimizing Multi-core MPI Collectives with SMARTMAP (2009)

We recently enhanced a lightweight compute node operating system with a simple page table mapping strategy that allows parallel application processes within a node to share effectively a single address space. This strategy allows for each process to maintain a normal, private address space, but also allows for processes to behave like threads that can freely read and write the memory of all processes on a node. In this paper, we demonstrate the benefits of this approach for improving the performance of MPI collective operations. In particular, we describe a new multi-threaded MPI reduce algorithm that outperforms existing approaches by as much as a factor of seven on a quad-core processor.
<title>Solvents in novolak synthesis</title> (1993)

Novolac resins may be prepared with or without a solvent present. We have found that solvent power greatly affects the properties of the finished resin and thus gives the resist chemist another variable with which to `fine-tune' resist properties. Using designed experiments, we investigated the effect of solvent power, as measured by Hansen's Solubility Parameters, of a number of solvents and solvent mixtures on the final properties of the novolac resin. We found that the relative molecular weight (RMW) and dissolution rate of a novolac resin can be varied by selection of a solvent or solvent mixture with the appropriate polarity and hydrogen- bonding characteristics. The solvent polarity and hydrogen-bonding characteristics may affect the stability of the cresol/formaldehyde transition state, thus causing the observed changes in RMW and dissolution rate.
Accelerated Hypofractionated Image-Guided vs Conventional Radiotherapy for Patients With Stage II/III Non–Small Cell Lung Cancer and Poor Performance Status (2021)

ClinicalTrials.gov Identifier: NCT01459497.
Passive Immunization with a Human Immunodeficiency Virus Type 1-Neutralizing Monoclonal Antibody in Hu-PBL-SCID Mice: Isolation of a Neutralization Escape Variant (1998)

A monoclonal antibody (694/98-D) directed toward the V3 loop of human immunodeficiency virus type 1 (HIV-1) was evaluated for pre- and postexposure prophylaxis in SCID mice reconstituted with human peripheral blood lymphocytes (Hu-PBL-SCID). Fifty percent protection against the HIV-1LAI strain was obtained by preexposure administration of 1.32 mg/kg antibody. However, virus isolated from 1 mouse 3 weeks after passive immunization with 13.2 mg/kg antibody proved resistant to subsequent in vitro neutralization by 694/98-D. V3 loop sequence analysis of cloned virus revealed amino acid changes within the linear core epitope recognized by 694/98-D and in one flanking amino acid. Further evaluation of 694/98-D for postexposure prophylaxis in mice revealed that 694/ 98-D was effective when given 15 min after virus. However, efficacy declined to 50% if treatment was delayed to 1 h after virus inoculation. These studies point out some potential drawbacks of passive immunization with monoclonal antibodies.
Time‐frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures (2013)

Time-frequency analysis of data from a wristband movement monitor could be utilized as a diagnostic tool to differentiate between epileptic and nonepileptic convulsive seizure-like events.
Thermally reversible crosslinking of polystyrene via the furan–maleimide Diels–Alder reaction (1992)

Abstract Mixtures of maleimidomethylated polystyrene with difurfuryl adipate or with furfuryl alcohol‐esterified poly[styrene‐co‐(maleic anhydride)] underwent thermally reversible Diels–Alder crosslinking. Reversal of crosslinking occurred rapidly at 150°C. The instability of the furfuryl group, however, limits the practicability of the reaction. © 1992 John Wiley &amp; Sons, Inc.
THE EFFECT OF INTRA-ARTERIAL HYDROGEN PEROXIDE IN RABBITS INFECTED WITH CLOSTRIDUM PERFRINGENS (1965)

BRADLEY, BRUCE E. Jr. LT, MC, USN; VEDROS, NEYLAN A. LT, MSC, USN; DEFALCO, ALFRED J. LT, MC, USNR; LAWSON, DEXTER W. LT, MC, USNR; VINEYARD, GORDON C. LT, MC, USNR; URSCHEL, HAROLD C. M.D. Author Information
FK506 binding protein associated with the calcium release channel (ryanodine receptor). (1992)

The calcium release channel (CRC)/ryanodine receptor (RyRec) has been identified as the foot structure of the sarcoplasmic reticulum (SR) and provides the pathway for calcium efflux required for excitation-contraction coupling in skeletal muscle. The CRC has previously been reported to consist of four identical 565-kDa protomers. We now report the identification of a 12-kDa protein which is tightly associated with highly purified RyRec from rabbit skeletal muscle SR. N-terminal amino acid sequencing and cDNA cloning demonstrates that the 12-kDa protein from fast twitch skeletal muscle is the binding protein for the immunosuppressant drug FK506. In humans, FK506 binds to the 12-kDa FK506-binding protein (FKBP12) and blocks calcium-dependent T cell activation. We find that FKBP12 and the RyRec are tightly associated in skeletal muscle SR on the basis of: 1) co-purification through sequential heparin-agarose, hydroxylapatite, and size exclusion chromatography columns; 2) coimmunoprecipitation of the RyRec and FKBP12 with anti-FKBP12 antibodies; and 3) subcellular localization of both proteins to the terminal cisternae of the SR, and not in the longitudinal tubules of SR, in fast twitch skeletal muscle. The molar ratio of FKBP12 to RyRec in highly purified RyRec preparations is approximately 1:4, indicating that one FKBP12 molecule is associated with each calcium release channel/foot structure.
Renal and antihypertensive effects of neutral endopeptidase inhibition in transgenic rats with an extra renin gene (1996)

The cardio+ascular consequences of neutral endopeptid>se INEP1 inhWtion with the NEP inhibitor ecadotxil were evaluated by determining acute and long-term effects of the compound on hemodynamic, hormonal, renal, and structural parameters in hypertensive transgemic rats harboring a mouse renin gene iTGR(m(Ren2)27)) and in normotensive controls (Sprague-Dawley rats, 3DX). Acute administration of ecadotril (10 and 30 mglkg, orally) produced a dose-dependent decrease in systolic blood pressure with a maximal effect of -23 mm Wg between 2 and 4 h after oral administration. The NEP activity in plasma was significantly inhibited and the plasma levels of at&al iANP j and brain iBii;P) natriuretic pep:ide; and their second messenger, cy& GMP, were distinctly raised after oral administration. In addition, ecadotril 110 and 30 mg/kg, orailyl produced a dose-dependent increase in the urinary excretion of sodium and cyclic GMF. These effects were more pronounced in TGR(mRen2i27 than in the normotensive SDR without a;. activated natriuid;
Narrow bandgap conjugated polymers based on a high-mobility polymer template for visibly transparent photovoltaic devices (2016)

In this contribution, starting from a high mobility polymer P2 with a regioregular D–A–D–A structure, we set out to further optimize the optical bandgap and energy levels for photovoltaic applications.
Cages and Needles of Group 13–15 Binary Hydrides (2006)

Cages or needles? Two structural families of group 13–15 binary hydrides, [HMYH]n, are investigated: cages and needles consisting of four- and six-membered rings (see figure). The cages are shown to be significantly stabilized by “in–out” isomeric hydrogenation. The importance of “in–out” isomerism sheds new light on the structural characteristics of cagelike compounds.
Mechanical-Bond-Protected, Air-Stable Radicals (2017)

Radical templation centered around a heterotrisradical tricationic inclusion complex DB<sup>•+</sup>⊂DAPQT<sup>2(•+)</sup>, assembled from an equimolar mixture of a disubstituted 4,4'-bipyridinium radical cation (DB<sup>•+</sup>) and an asymmetric cyclophane bisradical dication (DAPQT<sup>2(•+)</sup>), affords a symmetric [2]catenane (SC·7PF<sub>6</sub>) and an asymmetric [2]catenane (AC·7PF<sub>6</sub>) on reaction of the 1:1 complex with diazapyrene and bipyridine, respectively. Both these highly charged [2]catenanes have been isolated as air-stable monoradicals and characterized by EPR spectroscopy. X-ray crystallography suggests that the unpaired electrons are delocalized in each case across two inner 4,4'-bipyridinium (BIPY<sup>2+</sup>) units forming a mixed-valence (BIPY<sub>2</sub>)<sup>•3+</sup> state inside both [2]catenanes, an observation which is in good agreement with spin-density calculations using density functional theory. Electrochemical studies indicate that by replacing the BIPY<sup>2+</sup> units in homo[2]catenane HC<sup>•7+</sup>-composed of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings-with "zero", one, and two more highly conjugated diazapyrenium dication (DAP<sup>2+</sup>) units, respectively, a consecutive series of five, six, and seven redox states can be accessed in the resulting SC·7PF<sub>6</sub> (0, 4+, 6+, 7+, and 8+), HC·7PF<sub>6</sub> (0, 2+, 4+, 6+, 7+, and 8+), and AC·7PF<sub>6</sub> (0, 1+, 2+, 4+, 6+, 7+, and 8+), respectively. These unique [2]catenanes present a promising prototype for the fabrication of high-density data memories.