gebhart/patrepeval huggingface dataset:
Adaptive motion washout filter design by using self-tuning fuzzy control (2009)

The purpose of this research is to improve the motion-cueing fidelity of the simulator by using fuzzy-tuning technique to tune the parameters of washout filter in real-time.
Synchronization Techniques for Power Quality Instruments (2007)

The measurement of voltage characteristics in power systems requires the accurate estimation of the power supply frequency and signal synchronization, even in the presence of disturbances. The authors developed and tested two innovative techniques for instrument synchronization. The first is based on signal spectral analysis techniques performed by means of the Chirp- transform analysis. The second is a phase-locked loop (PLL) software based on a time-domain coordinate transformation and an innovative phase-detection technique. To evaluate how synchronization techniques are adversely affected by the application of a disturbing influence, experimental tests were carried out, taking into account the requirements of the standards. The proposed techniques were compared with a standard hardware solution. In this paper, the proposed techniques are described, the experimental results are presented, and the accuracy specifications are discussed.
A Trend of Yin-tonifying Formulas Compared with Yang-tonifying Formulas on Anti-platelet and Anti-thrombotic Activity (2009)

Objectives : Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity. Methods : We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane B2 immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice. Results : 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p Conclusion : These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.
Computability of the Fourier Transform and ZFC (2019)

In this paper we study the Fourier transform and the possibility to determine the binary expansion of the values of the Fourier transform in the Zermelo-Fraenkel set theory with the axiom of choice included (ZFC). We construct a computable absolutely integrable bandlimited function with continuous Fourier transform such that ZFC (if arithmetically sound) cannot determine a single binary digit of the binary expansion of the Fourier transform at zero. This result implies that ZFC cannot determine for every precision goal a rational number that approximates the Fourier transform at zero. Further, we discuss connections to Turing computability.
Aedes aegyptiLarval Indices and Risk for Dengue Epidemics (2006)

We assessed in a case-control study the test-validity of Aedes larval indices for the 2000 Havana outbreak. "Cases" were blocks where a dengue fever patient lived during the outbreak. "Controls" were randomly sampled blocks. Before, during, and after the epidemic, we calculated Breteau index (BI) and house index at the area, neighborhood, and block level. We constructed receiver operating characteristic (ROC) curves to determine their performance as predictors of dengue transmission. We observed a pronounced effect of the level of measurement. The BI max (maximum block BI in a radius of 100 m) at 2-month intervals had an area under the ROC curve of 71%. At a cutoff of 4.0, it significantly (odds ratio 6.00, p<0.05) predicted transmission with 78% sensitivity and 63% specificity. Analysis of BI at the local level, with human-defined boundaries, could be introduced in control programs to identify neighborhoods at high risk for dengue transmission.
Needle Insertion Robotic Systems for Image-guided Stereotactic Neurosurgery (2013)

In 1991, we have developed a needle insertion robotic system for CT-guided stereotactic neurosurgery. The system, based on existing stereotactic frame, had six DOF of movement with minimum size to fit a CT gantry.Safety issue was carefully considered: by cutting off the power supply, all axes were held rigidly to avoid unexpected motion. A phantom study using X-ray CT showed that the overall position error was 1.0mm. This system was followed by MRI-compatible version.This paper presents the history of this system and briefly reviews other stereotactic robots.
Nutritional‐rich and stress‐tolerant crops by saccharopine pathway manipulation (2012)

Abstract Lysine is a limiting essential amino acid in cereals, a major food source for humans and animals. Although cereals can synthesize lysine from aspartate, the pathway is feedback regulated in a manner that restricts lysine accumulation. Another step that restricts lysine accumulation in seeds is the saccharopine pathway for lysine catabolism. This pathway converts lysine to α ‐aminoadipic‐ δ ‐semialdehyde ( AASA ) by the bifunctional enzyme lysine‐ketoglutarate reductase/saccharopine dehydrogenase ( LKR / SDH ). Then, AASA is converted to aminoadipic acid ( AAA ) by α ‐aminoadipic‐ δ ‐semialdehyde dehydrogenase ( AASADH ). The downregulation of LKR / SDH in seeds results in the overaccumulation of free lysine to levels that meet human nutritional requirements. However, the saccharopine pathway is also involved in stress response in plants, animals, and bacteria. In these organisms, the gene encoding LKR / SDH is upregulated under osmotic, salt, and oxidative stress conditions. The role of the saccharopine pathway in stress response is not well understood, but the overexpression of AASADH results in stress‐tolerant plants and animal cells. The saccharopine pathway may thus act either by producing osmolytes, such as pipecolic acid and proline, or by signaling compounds that regulate stress‐response genes. In this review, we discuss the potential use of the saccharopine pathway to engineer nutritional‐rich and stress‐tolerant crops.
Bis(oxazoline) and Bis(oxazolinyl)pyridine Copper Complexes as Enantioselective Diels−Alder Catalysts:  Reaction Scope and Synthetic Applications (1999)

The scope of the Diels−Alder reaction catalyzed by bis(oxazoline) copper complexes has been investigated. In particular, [Cu((S,S)-t-Bu-box)](SbF6)2 (1b) has been shown to catalyze the Diels−Alder reaction between 3-propenoyl-2-oxazolidinone (2) and a range of substituted dienes with high enantioselectivity. This cationic complex has also been employed in the catalysis of analogous intramolecular processes with good success. The total syntheses of ent-Δ1-tetrahydrocannabinol, ent-shikimic acid, and isopulo’upone, featuring the use of this chiral catalyst in more complex Diels−Alder processes, are described. Similarly, the cationic copper complex 9a, [Cu((S,S)-t-Bu-pybox)](SbF6)2, is effective in the Diels−Alder reactions of monodentate acrolein dienophiles while the closely related complex, 9d [Cu((S,S)-Bn-pybox)](SbF6)2, is the preferred Lewis acid catalyst for acrylate dienophiles in reactions with cyclopentadiene.
Gene Expression Analysis by In Situ Hybridization: Radioactive Probes (2003)

Over the last several decades, an understanding of the events involved in embryonic pattern formation has been extended from an anatomic to a molecular level. In particular, the ability to examine the spatial and temporal expression of specific genes has aided greatly the analysis of their function. One of the most powerful techniques for determining gene-expression patterns is in situ hybridization, a method that relies on the hybridization of labeled antisense RNA probes to detect endogenous RNA transcripts at their sites of expression (1).
An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody‐Based Therapeutics in Overcoming Chemoresistance (2020)

The microenvironment plays a major role in conferring chemoresistance to cancer cells. In order to better inform clinical response to chemoresistance, preclinical models that recapitulate its hallmark features are needed to enable screening for resistance-specific therapeutic targets. A novel platform for seeding cancer cells in 3D hydrogels is presented utilizing derivatives of chitosan and alginate that, critically, is amenable to high throughput screening: cell seeding in hydrogels, media changes, dosing of anticancer compounds, and cell viability assays are all automated using a standard and commercially available liquid handling robot. Culture in these hydrogels elicits resistance in ovarian, lung, and prostate cancer cells to treatment by doxorubicin and paclitaxel. In correlation, proteomics analysis of SKOV3 cells cultured in 3D reveals enrichment of proteins associated with extreme drug resistance including HMOX1 and ALDH2. Subsequently, therapeutic antibodies targeted to tumor-associated antigens upregulated in 3D cultures are shown to have higher efficacy compared to 2D cultures. Collectively, this automated 3D cell culture platform provides a powerful tool with utility in identification of drugs that may overcome chemoresistance.
Effect of implementing sliding mode control on the dynamic behavior and robustness of switch mode power supply (Buck converter) (2004)

The focus of this paper is on the implementation of sliding mode control (SMC) for switch mode power supply. A brief analysis of the control structure is explained followed by a block diagram showing the internal structure of the control loops and the way they are connected to the converter. The buck converter was chosen as an example and the simulation model of the converter with its control circuit was build-up in matlab/simulink/sup /spl trade//. Once the circuit was build-up, the study of the dynamic response of buck converter controlled by SMC is done. The output voltage, inductor current, and the instant switching frequency are analyzed and studied in the following three regions: turn on region, line and load variation region, and finally components variation region. In the third part concerning robustness a wide range of change of the buck converter component parameters values are applied individually, and the study of the effect of SMC on the converter response due to these variations are analyzed.
Supplementary Methods and Materials, Figure 1, Tables 1-2 from Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3–Activating Compound (2023)

Supplementary Methods and Materials, Figure 1, Tables 1-2 from Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3–Activating Compound
Circularly Polarized Square Slot Antenna With a Pair of Inverted-L Grounded Strips (2008)

This paper presents a new wideband circularly polarized square slot antenna (CPSSA) with a coplanar waveguide (CPW) feed. The proposed antenna features two inverted-L grounded strips around two opposite corners of the slot and a widened tuning stub protruded into the slot from the signal strip of the CPW. Broadside circular-polarization (CP) radiation can be easily obtained using a simple design procedure. For the optimized antenna prototype, the measured bandwidth with an axial ratio (AR) of less than 3 dB is larger than 25% and the measured VSWR les 2 impedance bandwidth is as large as 52%.
Abciximab Adds No Benefit to Clopidogrel in Low- and Intermediate-Risk PCI (2004)

Routine use of platelet glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention (PCI) has shown the greatest benefits in patients with high risk for complications and in those with inadequate platelet antagonism. Now, in a partially industry-supported, multicenter, double-blind trial, researchers randomized 2159 low- and intermediate-risk patients (>95% in Europe) to placebo or the GPIIb/IIIa inhibitor abciximab. …
Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide (1996)

The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympathetic activity, decreases in parasympathetic outflow, and decreases in appetitive behavior. Urocortin, a neuropeptide related to CRF, binds with high affinity to the CRF2 receptor, is more potent than CRF in suppressing appetite, but is less potent than CRF in producing anxiety-like effects and activation. Doses as low as 10 nanograms injected intracerebroventricularly were effective in decreasing food intake in food-deprived and free-feeding rats. These results suggest that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite.
Expression of Legumain Correlates with Prognosis and Metastasis in Gastric Carcinoma (2013)

Legumain expression could serve as a prognostic biomarker in patients at risk of developing metastasis or recurrence with gastric carcinoma.
Noninvasive Assessment of Intracranial Pressure Status in Idiopathic Intracranial Hypertension Using Displacement Encoding with Stimulated Echoes (DENSE) MRI: A Prospective Patient Study with Contemporaneous CSF Pressure Correlation (2017)

This study establishes a relationship between pontine displacement from DENSE MR imaging and measured pressure obtained contemporaneously by lumbar puncture, providing a method to noninvasively assess intracranial pressure status in idiopathic intracranial hypertension.
Hydration in a new semiaromatic polyamide observed by humidity‐controlled dynamic viscoelastometry and X‐ray diffraction (2005)

Abstract Hydration in a new semiaromatic polyamide, named polyamide 9‐T (PA9‐T), a copolymer of terephthalic acid with n‐ and iso‐ nonanediamines, is studied by dynamic viscoelastic analysis under controlled humidity conditions and wide‐angle X‐ray diffraction analysis in comparison with common polyamide nylon 6. The storage modulus of PA9‐T is retained at up to 60 °C with increasing humidity, then dropped with further increases in temperature past 70 °C. The decrease in mechanical properties at 70 °C due to moisture uptake is found to be substantially improved by annealing to develop molecular packing and/or crystallization. In contrast, the storage modulus of very highly crystallized (50% crystallinity) nylon 6 decreases markedly with humidity at low temperatures such as 20 °C. Thus, PA9‐T retains its mechanical properties in humid atmospheres at much higher temperatures than nylon 6. The crystalline X‐ray diffraction peaks for nylon 6 corresponding to (002) + (202) of the α form shift upon absorption of moisture, speculated to be due to the weakening of hydrogen bonds and the subsequent conformational disordering of the chains. Unlike nylon 6, the crystalline peaks of PA9‐T do not shift due to moisture uptake. This is considered to be attributable to that the long aliphatic chain in PA9‐T forms the large hydrophobic domain, rendering PA9‐T less hygroscopic than nylon 6. Additionally, strong hydrogen bonds formed by terephthalamide residues together with a strong stacking force of phenylene groups may also repel water, preventing moisture bind with the amide groups of PA9‐T crystals. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 1640–1648, 2005
Combining Bevacizumab with Temozolomide Increases the Antitumor Efficacy of Temozolomide in a Human Glioblastoma Orthotopic Xenograft Model (2008)

In addition to the numerous mechanisms of action already identified for temozolomide, we report here that it also exerts antitumor effects by impairing angiogenic processes. We further emphasize that bevacizumab, which is an antiangiogenic drug with a different mechanism of action, could be useful in combination with temozolomide to increase the latter's therapeutic benefit in glioma patients.
Identification and discrimination ofStaphylococcus aureusstrains using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (2002)

Staphylococcus aureus is an important human pathogen frequently resistant to a wide range of antibiotics. Methicillin-resistant S. aureus (MRSA) strains are common nosocomial pathogens that pose a world-wide problem. Rapid and accurate discrimination between methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus is essential for appropriate therapeutic management and timely intervention for infection control. We report here the application of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) for monitoring the bacterial fingerprints expressed by two well characterized S. aureus strains ATCC 29213 (MSSA) and ATCC 43330 (MRSA). Consistent strain-specific data were obtained from subcultures analyzed over a period of three months as well as after changing the growth media from Mueller-Hinton to blood agar indicating the reliability of the method. The bacterial fingerprints of these two strains were compared to independent clinical isolates of S. aureus. A uniform signature profile for MRSA could not be identified. However, the bacterial fingerprints obtained proved to be specific for any given strain. This study demonstrates that MALDI-TOF MS is a powerful method for rapid identification of clonal strains of S. aureus, which might be useful for tracking nosocomial outbreaks of MRSA and for epidemiologic studies of infections diseases in general.
Demonstration of stability and splitting of optical vortex solitons (2015)

We report the first observation of robust optical vortex solitons (OVS) propagating in a uniform condensed medium featuring local self-focusing nonlinearity. OVS with topological charge m=1, that are stable over ~ 5 Rayleigh lengths, are excited in carbon disulfide using a helical light beam at 532 nm and intensities from 8 to 10 GW/cm^2. At larger intensities, the OVS loses its stability, spontaneously breaking into two fragments.Numerical simulations based on the nonlinear Schr\odinger equation including the three-photon absorption and nonpolynomial saturation of the Kerr term demonstrate close agreement with the experimental findings.
Semisynthetic and Biomolecular Hydrogen Evolution Catalysts (2015)

There has been great interest in the development of stable, inexpensive, efficient catalysts capable of reducing aqueous protons to hydrogen (H2), an alternative to fossil fuels. While synthetic H2 evolution catalysts have been in development for decades, recently there has been great progress in engineering biomolecular catalysts and assemblies of synthetic catalysts and biomolecules. In this Forum Article, progress in engineering proteins to catalyze H2 evolution from water is discussed. The artificial enzymes described include assemblies of synthetic catalysts and photosynthetic proteins, proteins with cofactors replaced with synthetic catalysts, and derivatives of electron-transfer proteins. In addition, a new catalyst consisting of a thermophilic cobalt-substituted cytochrome c is reported. As an electrocatalyst, the cobalt cytochrome shows nearly quantitative Faradaic efficiency and excellent longevity with a turnover number of >270000.
Electrostatic Extraction of Cold Molecules from a Cryogenic Reservoir (2009)

We present a method which delivers a continuous, high-density beam of slow and internally cold polar molecules. In our source, warm molecules are first cooled by collisions with a cryogenic helium buffer gas. Cold molecules are then extracted by means of an electrostatic quadrupole guide. For ND3 the source produces fluxes up to (7+/- 4(7)) x 10(10) molecules/s with peak densities up to (1.0+/- 0.6(1.0)) x 10(9) molecules/cm3. For H2CO the population of rovibrational states is monitored by depletion spectroscopy, resulting in single-state populations up to (82+/-10)%.
Reversible Stereodivergent Cycloaddition of Racemic Helicenes to [60]Fullerene: A Chiral Resolution Strategy (2018)

[60]­Fullerene and\nits rarely explored reversible covalent chemistry\nhave been harnessed as an efficient alternative for the chiral resolution\nof racemates. By using only catalytic amounts of chiral agents, stereodivergent\n1,3-dipolar cycloadditions of racemic helicenes onto [60]­fullerene\nwere carried out. The formed helicene/fullerene diastereomers were\neasily separated by conventional chromatography, and afterward, a\nsimple catalyzed 1,3-dipolar retro-cycloaddition afforded helicene\nstarting materials in high optical purity.
« Complex dielectric permittivity measurement et the nanoscale using EFM : a prospective study (Invited) (2008)

International audience
Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate (2019)

Two efficient continuous flow iodoperfluoroalkylation methods are described: using 0.05 mol % perylene diimide (PDI) photocatalyst under 450 nm irradiation or substoichiometric triethylamine under 405 nm irradiation. These methods enable dramatically elevated productivity versus batch processes. The triethylamine-mediated method is explored mechanistically and in substrate scope. The gram-scale synthesis of an active pharmaceutical ingredient side chain is also reported in flow, via a photochemical iodoperfluoroalkylation followed by hydrogenolysis.
eFish- Genomic Database Repository (Raw sequences of Carcharias taurus) (2016)

Raw sequences of Carcharias taurus BioVoucher: 2015-CTA-001. Compressed RAR files, containing two FASTQ files; 500 Mb per file. More info: http://www.molecularfisherieslaboratory.com.au/efish/
Overcoming Email Addiction: Understanding the 'Leave Me Alone!' Approach (2009)

Almost a necessity for communication, email consumes significant portions of knowledge workersâ time in todayâs organizations. Though issues such as spam, filtering, and archiving have received much attention from industry and academia, the critical problem of the timing of email processing has not been studied much. It is common for many knowledge workers to check and respond to their emails almost continuously. Though some emails may require very quick responses, continuous email checking may lead to workplace interruptions and overload. This study presents a framework for studying email response timing approaches to minimize the communication times and yet reduce the interruptive effects. A rigorous analysis of the effective and efficient email processing policies, in a series of two-phase simulated virtual experiments, is performed by comparing various ways to reduce interruptions for various work settings. Findings suggest that managing email processing can make a significant difference in workplace productivity.
Effect of Exchange Interaction on Spin Dephasing in a Double Quantum Dot (2005)

We measure singlet-triplet dephasing in a two-electron double quantum dot in the presence of an exchange interaction which can be electrically tuned from much smaller to much larger than the hyperfine energy. Saturation of dephasing and damped oscillations of the spin correlator as a function of time are observed when the two interaction strengths are comparable. Both features of the data are compared with predictions from a quasistatic model of the hyperfine field.
Recent Advances in the Molecular Genetic Analysis of Candida albicans Morphogenesis. (1995)

Candida albicansの二形性変換(酵母形から菌糸形への形態変換)は病原性発現の一因子と考えられている.二形性のメカニズムおよびこの現象がどの程度病原性発現に寄与しているかについて以前から膨大な研究がなされてきたが,詳細はいまだ不明である.近年,Candidaの研究分野にも急速に分子遺伝学の技術が導入され,二形性変換の研究分野でも遺伝学的な背景を明らかにすることを目的とした新たな展開が始まっている.この小論は二形性変換における遺伝子発現研究に焦点を当てて最近の知見を紹介し,この現象を分子生物学的に解き明かすためのアプローチについて考察した.