gebhart/patrepeval huggingface dataset:
El mundo taurino en la poesía y prosa taurina de Gerardo Diego (2013)

He aquí un libro único en su especie: Poesías y Prosas Taurinas de Gerardo Diego. La prosa taurina está instrumentada a la manera del ensayo, por lo tanto, de ella emanan conceptos, juicios y argumentos útiles para develar la imaginería contenida en la poesía taurina. A través de la prosa taurina el lector obtendrá recursos para comprender y valorar las imágenes poéticas. Además, y como valor agregado, el lector en vísperas de convertirse en aficionado-espectador conseguirá elementos para apreciar mejor lo que sucede en una corrida de toros, mismos que se utilizan para bien mirar cualquier faena contingente y su participación en la faena eterna.
Computed tomography model-based treatment of atrial fibrillation and atrial macro-re-entrant tachycardia (2008)

For patients with AF and MRT, our study shows the feasibility of successful placement of complex linear ablation line concepts guided by an integrated 3D image anatomy alone rather than catheter-based virtual chamber surface reconstructions.
Selective detection of aroma components by acoustic wave sensors coated with conducting polymer films (1996)

Eight conducting polymer films of polypyrrole and its derivatives were used as sensitive and selective coatings for thickness-shear mode (TSM) acoustic wave sensors. They were applied to the detection of volatile alcohols and carbonyl compounds, which are important fish freshness determinants. The conducting polymers were synthesized and coated on TSM devices by electrochemical oxidation. The exposure of the coated TSM sensors to four compounds (pent-1-en-3-ol, oct-1-en-3-ol, nona-3,6-dien-1-ol and nona-2,6-dienal) was investigated, and a linear response with concentration found for the different aroma components. The sensor response was also found to be proportional to the film thickness. The response patterns obtained by grouping the data from the individual sensors are characteristic for each aroma molecule, and were investigated using both cluster and principal components analysis. The results demonstrate the feasibility of fish freshness determination through the use of a TSM sensor array combined with pattern recognition techniques.
Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing (2020)

Rapid and continuing advances in biomarker testing are not being matched by take-up in health systems, and this is hampering both patient care and innovation. It also risks costing health systems the opportunity to make their services more efficient and, over time, more economical. The potential that genomics has brought to biomarker testing in diagnosis, prediction and research is being realised, pre-eminently in many cancers, but also in an ever-wider range of conditions. One of the paradigmatic examples is BRCA1/2 testing in ovarian, breast, pancreatic and prostate cancers. Nevertheless, development is impeded by data deficiencies, and lack of policy alignment on standards, approval &amp;ndash; and the role of real-world evidence in the process - and reimbursement. The acute nature of the problem is compellingly illustrated by the particular challenges facing the development and use of tumour agnostic therapies, where the gaps in preparedness for taking advantage of this innovative approach to cancer therapy are sharply exposed. Europe should already have in place a guarantee of universal access to a minimum suite of biomarker tests and should be planning for an optimum testing scenario with a wider range of biomarker tests integrated into a more sophisticated health system articulated around personalised medicine. Improving healthcare and winning advantages for Europe's industrial competitiveness and innovation require an appropriate policy framework &amp;ndash; starting with an update to outdated recommendations.
Thick Film Conductors and Resistors on Dielectrics for High Reliability Applications (1985)

Platinum gold conductors, used as solderable terminations, contain a glass frit which reacts with the minority constituents in debased alumina substrates forming an adhesive bond. Some conductor inks also contain copper and cadmium, in addition to the glass frit, which react directly with the alumina to form a chemical bond. Dielectric inks contain a crystalline filler, such as alumina or zirconia, in a glass matrix. The effect on the physical and electrical properties of platinum golds on various dielectrics was examined in comparison with the behaviour on alumina. Composition and surface structure of the dielectric affects the adhesion strength, solderability and solder leach resistance of the conductor inks. Interaction between the glasses in the dielectrics and conductors was determined by analysis in the SEM. Interdiffusion between the conductor and solder metals occurs and brittle intermetallic compounds are formed. The effects of the intermetallic formation on the adhesion strength and modes of failure, especially after thermal ageing at 150°C, have been examined. Thick film resistors printed and fired onto dielectrics rather than onto alumina substrates generally have different electrical properties. Chosen resistor systems, terminated with a gold conductor, were evaluated on different dielectrics. The values of electrical parameters such as resistance, TCR and noise index were compared with those on alumina. Interactions between the glasses in the resistors and dielectrics were examined as for the conductors. Thermal ageing on various resistor/dielectric combinations was carried out in order to determine the long-term stability. The activation energies and time dependences of the ageing mechanisms for each combination were found. Corresponding ageing equations were calculated in order to predict the likely behaviour during life.
Mise en page et mise en voix : le cas de Mallarmé (2015)

International audience
Properties of SiO2 and Si3N4 as gate dielectrics for printed ZnO transistors (2011)

In this article, the authors report on thin film transistors based on gas phase synthesized ZnO nanoparticles using low temperature deposited silicon dioxide and silicon nitride as gate dielectrics. For bottom gate transistors, the devices using silicon nitride as gate insulator show the lowest off-current for a given induced charge and the steepest subthreshold slope. The charge carrier mobility of around 3×10−3 cm2/V s and an Ion/Ioff ratio of around 105 are almost independent of the insulator material. In a double gated thin film transistor using low stress silicon nitride as a top gate insulator, transistor parameters are extracted for the identical semiconducting layer when the bottom and top gates are used. It is shown that the extracted charge carrier mobility is not inherent for the ZnO nanoparticle layer but rather an effective value for the device under investigation.
On the union of chord-like networks (2004)

We address the infrastructure of chord-like networks union. Chord merger is not a good idea for security reason. In this paper we propose Hamming metric union in chord-like networks from the initial view of alleviating the security problem, in which intra-network and inter-network routing are served based on a two dimensional structure. We discuss the routing procedure in detail where network shifted neighbor selection and nearest destination Hamming weight forwarding are explored. It has been proved that this routing in the united chord network is more efficient than chord itself.
A fuzzy-smooth variable structure filtering strategy: For state and parameter estimation (2013)

This article introduces a new filtering strategy based on combining elements of fuzzy logic and the smooth variable structure filter (SVSF). A revised formulation of the SVSF is presented in an effort to combine it with fuzzy logic, and is referred to as the RSVSF. Computer simulations are used to compare the new strategy, referred to as the Fuzzy-SVSF, with other popular Kalman-based estimation methods. Preliminary results indicate that combining fuzzy logic with the SVSF yields an improved estimation result and improved stability to system and modeling changes and uncertainties.
Transforming Environmental Health Protection (2008)

We propose a shift from primarily in vivo animal studies to in vitro assays, in vivo assays with lower organisms, and computational modeling for toxicity assessments.
Noninvasive Model-Based Open-Circuit Switch Fault Detection of AC-Bypass Leg Switches in Transformerless PV Inverter (2021)

Transformerless inverters are being used for integrating photovoltaic (PV) sources into the grid. Highly efficient and reliable inverter concept (HERIC) inverter is one such topology, which is derived from an H-bridge by adding a bypass leg on the ac side using two back-to-back insulated gate bipolar transistors (IGBTs). Open-circuit fault in the bypass leg would result in conduction of current through antiparallel diodes of the main switches of the inverter, effectively making the inverter operate in bipolar mode. As a result of the fault, there would not be an issue of leakage current, and the operation would continue at the expense of increased conduction losses and dc-offset in the grid current. This article proposes an online noninvasive model-based technique to detect switch faults in the bypass leg of the HERIC inverter. The grid current at the peak of the carrier signal is predicted based on the measured grid current at the start of the zero states. By comparing the estimated and measured grid currents at the peak of the carrier signal, the faulty switch in the bypass leg is localized. Once the fault is localized, the inverter’s modulation scheme is changed to conventional bipolar mode to improve the performance of the converter during the post-fault stage. A detailed simulation study is carried out to verify the effectiveness of the proposed approach. Experimental tests on the prototype converter show that the proposed algorithm can reliably detect the open-circuit fault in switches of the bypass leg, and once a fault is detected, the algorithm would change the modulation scheme to bipolar mode to minimize the inverter loss and dc-offset in the grid current.
The benefit of whole-body low-dose unenhanced multidetector computer tomography (WBLD-MDCT) for follow up and therapy response monitoring in patients with multiple myeloma: Correlation with hematologic parameters (2006)

7607 Background: To assessthe value of whole-body low-dose multidetector computer tomography (WBLD-MDCT) as diagnostic and survey modality in multiple myeloma (MM), and as a one-stop alternative (Horger et al. EJR 2005;54:289–297) to established imaging techniques (e.g. x-ray and MRI). Methods: Between 7/2001 and 2/2005, WBLD-MDCT scans were obtained in 90 consecutive patients with histologically proven stage II-III MM, all patients having 2 or more scans (mean = 3,8; range = 2–6). CT-scans were performed using a standardized low-dose protocol and the number, size and density of focal or diffuse medullary (in the appendicular skeleton and pelvis) and extra-medullary lesions as well as osteolysis were analysed for each examination and at follow up. Results were correlated with current standard MM laboratory data and at follow up in order to assess correct temporal recognition of significant myeloma changes by both methods. Results: Detection and follow up of medullary and extra-medullary MM lesions and osteolysis by WBLD-MDCT resulted in a sensitivity of 92%, a specificity of 93%, a NPV of 95%, a PPV of 85% and a likelihood ratio for patients with CT-abnormalities to present changes in the course of their disease of 12. Results of radiologic and hematologic analysis showed high agreement at follow up (median, 3 mo). However, agreement of both techniques at the time of investigation was only moderate (κ = 0.629), with CT being correct in 60% of mismatching cases. Thus, CT enabled earlier detection of MM changes. WBLD-MDCT assessed correctly the course of disease in all 4 patients with nonsecretory MM. Evaluation of stability was optimal in all patients. Conclusions: WBLD-MD represents a reliable, widespread, quick (75s acquisition time), and cost-effective imaging technique in MM, allowing detection of bone marrow involvement, extra-medullary tumors and lytic bone lesions in different clinical settings (staging, follow up, therapy monitoring, evaluation of stability). WBLD-MDCT repeatedly allowed detection of changes in the course of the disease prior to laboratory data, especially in extramedullary MM relapse and nonsecretory MM. No significant financial relationships to disclose.
Comparison of Two Homogeneous Cell-Based Kinase Assays for JAK2 V617F: SureFire pSTAT5 and GeneBLAzer Fluorescence Resonance Energy Transfer Assays (2011)

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays an important role in cellular responses to cytokines and growth factors. Recent studies have identified a recurrent somatic activating mutation (JAK2 V617F) in majority of patients with myeloproliferative disorders (MPDs). Development of drugs that target JAK2 V617F is, therefore, of therapeutic relevance. To discover small molecule inhibitors for this target, robust and reliable cell-based assays are important. Here, we present a comparison of two homogeneous, 384-well plate-based cellular assays using Invitrogen's CellSensor® JAK2 V617F interferon regulatory factor-1 (irf1)-beta-lactamase (bla) human erythroleukemia line (HEL): (1) SureFire® pSTAT5 AlphaScreen® assay from PerkinElmer; and (2) GeneBLAzer® fluorescence resonance energy transfer assay from Invitrogen. HEL cells are growth factor-independent due to JAK2 V617F mutation that causes constitutive STAT5 activation. The SureFire assay measures levels of phosphorylated STAT5 downstream of JAKs, while the GeneBLAzer assay is a reporter assay that monitors bla activity further downstream of STAT5. Evaluation of a number of chemically diverse JAK2 inhibitors in the two cellular assays yielded comparable half-maximal inhibitory concentration (IC₅₀) values, boding well for the utility of these assay formats in compound profiling.
Design of a broadband cross-shaped patch antenna for phased array (2016)

In this paper, a wide bandwidth, wide-angle patch antenna with acceptable circular polarization performance is presented. The antenna combines the advantages of capacitance coupling feed, backed cavity and a feed network based on Wilkinson power divider, exhibiting an excellent performance. When the antenna is located in an array, it shows low-level mutual coupling and broader beamwidth. The characteristics make the antenna an ideal choice for phased array. Both simulated and measured results demonstrate that the antenna can achieve a wide bandwidth of 110° with 28% bandwidth and for S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> <;-10dB with 30% bandwidth.
Self-Assembled Three-Dimensional Non-Volatile Memories (2010)

The continuous increase in capacity of non-volatile data storage systems will lead to bit densities of one bit per atom in 2020. Beyond this point, capacity can be increased by moving into the third dimension. We propose to use self-assembly of nanosized elements, either as a loosely organised associative network or into a cross-point architecture. When using principles requiring electrical connection, we show the need for transistor-based cross-talk isolation. Cross-talk can be avoided by reusing the coincident current magnetic ring core memory architecture invented in 1953. We demonstrate that self-assembly of three-dimensional ring core memories is in principle possible by combining corner lithography and anisotropic etching into single crystal silicon.
Concentration fields in evaporating droplets (2003)

Abstract An analytical solution of the problem of diffusional mass transport inside a spherical binary mixture droplet is presented. The droplet evaporates according to the d2-law. Mass fraction profiles of the mixture components are obtained as series expansions in confluent hypergeometric, Legendre and sine/cosine functions. The analytical description is valid for arbitrary ratio of the rate of shrinkage of the sphere surface to the diffusion coefficient in the liquid phase. The results allow for a prediction of the morphology of the dried particles, i.e., whether hollow or solid spheres result from the drying process. The field of application of the results presented is spray drying of solutions of solid substances.
Osteoinductivity of Commercially Available Demineralized Bone Matrix (2004)

This study demonstrated differences in the osteoinductive potentials of commercially available demineralized bone matrices in this animal model.
Cobalt Nano Particle Size Dependence of Noise Modulations in Relation to Nonlinearity (2010)

Carbon nanotubes (CNTs) are low-dimensional materials, and their surface therefore affects several properties of CNTs. For example, CNT field effect transistors (CNTFETs) are well known as noisy devices caused by the adhesion of molecules on the surface. However, nonlinear systems sometimes have advantages in working with noise. Therefore, we combined the noise CNTFET and another transistor of CNT for a trial nonlinear system. The sine wave amplification in the transistor with noise was then measured. In this system, the control of noise is required for operation of the device and this might be common for nano-sized devices. We can control the noise properties of CNTFET through the control of the Co nano particles catalyst. Depending on fabrication conditions, the noise of a CNTFET has different noise intensity and gate voltage (Vg) dependence with 1/f type noise. Noise in CNTFETs grown on small Co particles can be controlled within the small |Vg|, and the control range for noise is wide. We studied the modification of nonlinearity using our trial nonlinear system. It was governed by the ratio of the signals and the noise, and shows the robustness of modification. [DOI: 10.1380/ejssnt.2010.115]
SAKK 16/14: Durvalumab in Addition to Neoadjuvant Chemotherapy in Patients With Stage IIIA(N2) Non–Small-Cell Lung Cancer—A Multicenter Single-Arm Phase II Trial (2021)

The addition of perioperative durvalumab to neoadjuvant chemotherapy in patients with stage IIIA(N2) non-small-cell lung cancer is safe and exceeds historical data of chemotherapy alone with a high MPR and an encouraging 1-year EFS rate of 73%.
Electrical reversion of cardiac arrhythmias. (1967)

Graybiel in Florida-to name but a few.From Thomas Lewis they obtained above all else a scientific approach to medical experimentation.This displaced the then prevalent and shopworn ideas based on the subjectivity and the intuition of the chosen few.The hallmarks of Thomas Lewis's method of work were the application of precisely controlled and exacting methods, the assiduous gathering of evidence, the rigorous censorship of data, and the recognition of the role of animal ex- periments as a proper domain for inquiry into many complex clinical problems.The yield of his legacy is not a harvest for a single season, and the rich fruit is still being gathered.This very lecture was initi- ated by his student and my teacher, Doctor Samuel A. Levine.Yet there is a more intimate kinship I wish to expose for your consideration: namely, that the
Adverse reactions to co-trimoxazole in HIV infection: A reappraisal of the glutathione-hydroxylamine hypothesis (1996)

It is postulated that the unstable hydroxylamine metabolite of sulphamethoxazole is responsible for the adverse reactions to co-trimoxazole and in HIV infection systemic glutathione deficiency leads to a reduced capacity to counteract the hydroxylamine toxicity. This hypothesis has been investigated by studying the metabolism of sulphamethoxazole and assessing glutathione status in HIV infection in order to explore the modification of treatment. It is concluded that the toxicity of plasma sulphamethoxazole hydroxylamine is counteracted by normal glutathione concentrations as is the case in HIV-seropositive patients, but that increased oxidation within certain cells in HIV infected individuals may possibly give rise to increased concentrations of reactive intermediates of sulphamethoxazole. Sulphametrole and sulphamethoxazole have similar half-lives but are metabolized differently: in vivo no oxidised metabolites of sulphametrole could be detected. In a retrospective study the rate of adverse reactions to trimethoprim-sulphametrole appeared to be in the lower range of those reported for trimethoprim-sulphamethoxazole indicating that the combination of trimethoprim-sulphametrole may be more favourable. The ratio of trimethoprim:sulphonamide is 1:5, but in-vitro studies with Toxoplasma gondii indicate that because of the synergic effect of both agents the dose of sulphonamide is possibly unnecessarily high.
Novel adaptive control system for ultrasound hyperthermia treatment of prostate disease (2004)

A novel model reference adaptive control (MRAC) method was proposed and tested with a transrectal intracavitary applicator for thermal treatment of prostate disease using ultrasound hyperthermia. Two significant advantages of this innovative adaptive control method are: 1) there is no need of a priori knowledge of the tissue properties; and 2) the controller could adaptively change the amplitudes and phases of the array's driving signal according to the perfusion rate or other dynamic tissue properties. Computer simulations, ex vivo and in vivo experimental results all showed that with this adaptive controller the tissue was heated up to 43 /spl plusmn/ 0.2/spl deg/C within 7 /spl plusmn/ 2 minutes, and adaptively maintained 43/spl deg/C with dynamic blood flow for the rest period of the hyperthermia.
Design of low jitter phase-locked loop with closed loop voltage controlled oscillator (2015)

This paper presents a novel phase-locked loop (PLL) architecture to generate a low jitter output clock with a closed loop voltage controlled oscillator (VCO). The proposed closed loop VCO consists of an open loop VCO, an integrator, a non-overlapping clock generator and a switched-capacitor resistor. Because the closed loop VCO has a high-pass characteristic for a VCO noise transfer function and a negative feedback loop suppresses a phase noise of the open loop VCO, the closed loop VCO shows the low phase noise compared to the conventional open loop VCO. Moreover, the closed loop VCO can filter any perturbation at the control voltage due to a low-pass characteristic of input voltage transfer function. We design the proposed PLL scheme in 130 nm low power CMOS technology at 1.5V supply. An integrated RMS jitter is 5.81 psec at 300 MHz output frequency, which is 24% smaller than the jitter of previous PLL with the open loop VCO. The proposed PLL consumes 4.8 mW at 400 MHz output frequency.
Preferential increase of B-cell activating factor in the cerebrospinal fluid of neuromyelitis optica in a white population (2010)

The presence of increased BAFF, a soluble factor associated with B-cell activation in the proximity of the disease target organ (CSF) in NMO, and its increase in association with immunomodulating treatments, may help our understanding of the immunopathogenetic mechanisms involved in this disease and contribute to more successful and targeted therapeutic intervention.