gebhart/patrepeval huggingface dataset:
Modeling hair using level-of-detail representations (2004)

We present a novel approach for modeling hair using level-of-detail representations. The set of representations include individual strands, hair clusters, and hair strips. They are represented using subdivision curves or surfaces, and have the same underlying base skeleton to maintain consistent high-level physical behavior when a transition between different levels-of detail occurs. This framework supports automatic simplification of dynamic simulation, collision detection, and graphical rendering of animated hair. It also offers flexibility to balance between the overall performance and visual quality, and can be used to model and render different hairstyles. We have used these level-of-detail representations to animate various hairstyles and obtained noticeable performance improvement, with little loss in visual quality.
Synthesis and Purification of a Hammerhead Ribozyme and a Fluorescein-Labeled RNA Substrate. A Biochemistry Laboratory: Part 1 (1999)

The applications of in vitro transcription and chemical synthesis of RNA are discussed. This laboratory describes the in vitro synthesis of a 38-nucleotide hammerhead ribozyme and the synthesis of a 17-nucleotide fluorescein-labeled RNA substrate by using standard phosphoramidite methodologies, two widely used methods in modern RNA research. The synthesis and purification procedures outlined allow students to develop an understanding of RNA handling procedures, synthesis of modified nucleic acids, gel electrophoresis, visualization of RNA by nonradioactive techniques, and quantitation of nucleic acids. The RNAs that are synthesized have applications in biotechnology and medicine; thus the students gain access to current problems in chemical and clinical research.
Synthese substituierter 3‐Adamantyloxocumarine unter Piperidinacetat/β‐Alanin‐Katalyse (1983)

Abstract Es wird die Synthese der substituierten‐3‐Adamantyloxocumarine 3a‐h aus den Hydroxyaldehyden 1a‐h und der Knoevenagel ‐Komponente 2 beschrieben. Als Katalysator benutzt man Piperidinacetat/β‐Alanin.
Chemical fatty acylation confers hemolytic and toxic activities to adenylate cyclase protoxin of Bordetella pertussis (1994)

Adenylate cyclase toxin (ACT), a virulence factor of Bordetella pertussis, acquires hemolytic and toxic activities after post-translational modification of the cyaA gene product, CyaA. The exact nature of this modification is unknown, but homology to the related repeat toxin alpha-hemolysin of Escherichia coli suggests that fatty acylation of a lysine residue may be involved. In the present study, we used an in vitro chemical approach to acylate unmodified, inactive adenylate cyclase protoxin by using a new water-soluble compound, acylpyrophosphate. We show that undirected transfer of lauric, myristic, or palmitic acid chains to the CyaA protoxin is able to confer both hemolytic and toxic activities to ACT. The chemically modified protoxin shows a specific requirement for Ca2+ ions for toxic activity, as does the wild type toxin. However, the toxic and hemolytic activities of chemically modified ACT are low in comparison to ACT modified in vivo, suggesting that in vitro fatty acylation of the protoxin involves random modification of nucleophilic residues present in the toxin in contrast to the in vivo modification of specific sites.
Probabilistic vs linear blending approaches to shared control for wheelchair driving (2017)

Some people with severe mobility impairments are unable to operate powered wheelchairs reliably and effectively, using commercially available interfaces. This has sparked a body of research into "smart wheelchairs", which assist users to drive safely and create opportunities for them to use alternative interfaces. Various "shared control" techniques have been proposed to provide an appropriate level of assistance that is satisfactory and acceptable to the user. Most shared control techniques employ a traditional strategy called linear blending (LB), where the user's commands and wheelchair's autonomous commands are combined in some proportion. In this paper, however, we implement a more generalised form of shared control called probabilistic shared control (PSC). This probabilistic formulation improves the accuracy of modelling the interaction between the user and the wheelchair by taking into account uncertainty in the interaction. In this paper, we demonstrate the practical success of PSC over LB in terms of safety, particularly for novice users.
Use of Temperature for Standardizing the Progression of Francisella tularensis in Mice (2012)

The study of infectious agents, their pathogenesis, the host response and the evaluation of newly developed countermeasures often requires the use of a living system. Murine models are frequently used to undertake such investigations with the caveat that non-biased measurements to assess the progression of infection are underutilized. Instead, murine models predominantly rely on symptomology exhibited by the animal to evaluate the state of the animal's health and to determine when euthanasia should be performed. In this study, we used subcutaneous temperature as a non-subjective measurement to follow and compare infection in mice inoculated with Francisella tularensis, a Gram-negative pathogen that produces an acute and fatal illness in mice. A reproducible temperature pattern defined by three temperature phases (normal, febrile and hypothermic) was identified in all mice infected with F. tularensis, regardless of the infecting strain. More importantly and for the first time a non-subjective, ethical, and easily determined surrogate endpoint for death based on a temperature, termed drop point, was identified and validated with statistical models. In comparative survival curve analyses for F. tularensis strains with differing virulence, the drop point temperature yielded the same results as those obtained using observed time to death. Incorporation of temperature measurements to evaluate F. tularensis was standardized based on statistical models to provide a new level of robustness for comparative analyses in mice. These findings should be generally applicable to other pathogens that produce acute febrile disease in animal models and offers an important tool for understanding and following the infection process.
Theoretical analysis for spherical aberration induction with low-order correction in refractive surgery: comment (2012)

In this paper, we reply to post-surgical corneal asphericity conclusions made by Dai [Appl. Opt.51, 3966 (2012)]. We deduced, after a theoretical analysis, that the conclusions derived from this analysis are not theoretically or experimentally sound, because the author considers only the Munnerlyn formula for ablation algorithms and not the paraxial Munnerlyn formula, which is widespread in refractive surgery [J. Cataract Refract. Surg.14, 46 (1988)]. We refer to a previous paper published by Jiménez et al. [J. Opt. Soc. Am. A21, 98 (2004)] for a complete analysis on this matter that clarifies some points of confusion in Dai's paper.
Feedforward frequency estimation for PSK: A tutorial review (1998)

Abstract This paper considers feedforward carrier frequency estimation methods in burst‐mode digital transmission, with tutorial objectives foremost. Assuming PSK modulation, two scenarios are envisaged in which frequency estimates are derived either from a preamble appended to the data block, or directly from the modulated signal. Several estimation algorithms are considered with different and somewhat contrasting characteristics. The characteristics we focus on are: estimation accuracy, estimation range, minimum operating signal‐to‐noise ratio (threshold), and implementation complexity. They provide a framework within which current estimation methods can be evaluated. The paper reviews and compares some prominent algorithms proposed in literature, trying to single out the best ones for a given application.
Pedestrian Dead Reckoning and its applications (2009)

First, we briefly introduce the technologies of PDR (Pedestrian Dead Reckoning) that can be used to track the location and orientation of a pedestrian. Secondly, we show some enhancement of the PDR to improve its performance on accuracy. Finally, we describe the applications of the PDR.
Transient chirping in distributed-feedback (DFB) lasers: effect of spatial hole-burning along the laser axis (1988)

An analysis of the chirping behavior of directly modulated distributed-feedback (DFB) lasers which takes into consideration the effects of spatial hole-burning along the laser axis is discussed. Rate equations including these effects are derived. To calculate the rate equations, the threshold condition of phase-shifted DFB lasers with a nonuniform refractive index distribution is analyzed. The calculations are carried out on phase-shifted DFB structures under the condition of random nonreturn to zero modulation at 1.8 Gb/s. The results show that the spatial hole-burning along the axis significantly affects the chirping behavior, adding to the effects induced by the spectral hole-burning alone.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Temporal inhomogeneity in brachial artery blood flow during forearm exercise (1997)

The purpose of this study was to measure the influences of muscle contraction and exercise intensity on brachial artery blood flow during incremental forearm wrist flexion exercise to fatigue. Twelve subjects performed incremental forearm exercise (increments of 0.1 W every 5 min) with their nondominant arms. Doppler waveforms and two-dimensional images of the brachial artery were recorded during the last 2 min of each stage. Exercise intensities were expressed as a percent of the maximal workload achieved (%WLmax). Blood flow was calculated during each of the concentric (CP), eccentric (EP), and recovery phases (RP) of the contraction cycle. Blood flow during the CP of the contraction did not increase above resting values (25.0 +/- 10.5 mL.min-1) at any intensity (100%WLmax = 21.6 +/- 6.5 mL.min-1). Conversely, blood flow during the EP and RP increased from 25.6 +/- 3.0 to 169.1 +/- 12.8 (P < 0.05), and from 24.7 +/- 3.1 to 137.9 +/- 19.5 mL.min-1 (P < 0.05), respectively from rest to maximal exercise. Time averaged blood flow increased linearly from rest to maximal exercise (75.3 +/- 26.3 to 334.6 +/- 141.6 mL.min-1, P < 0.05). Thus, a significant impairment in blood flow occurs with concentric contractions during forearm dynamic exercise. The implications of a temporal disparity in blood flow to oxygen delivery and skeletal metabolism during exercise are discussed.
A General Framework for Self-Organizing Structure Processing Neural Networks (2003)

Self-organization constitutes an important paradigm in machine&#13;\nlearning with successful applications e.g. for data- and web-mining.&#13;\nHowever, so far most approaches have been proposed for data contained&#13;\nin a fixed and finite dimensional vector space. We will focus on&#13;\nextensions for more general data structures like sequences and tree&#13;\nstructures in this article. Various extensions of the standard&#13;\nself-organizing map (SOM) to sequences or tree structures have been&#13;\nproposed in the literature: the temporal Kohonen map, the recursive&#13;\nSOM, and SOM for structured data (SOMSD), for example. These methods&#13;\nenhance the standard SOM by recursive connections. We define in this&#13;\narticle a general recursive dynamic which enables the recursive&#13;\nprocessing of complex data structures based on recursively computed&#13;\ninternal representations of the respective context. The above&#13;\nmechanisms of SOMs for structures are special cases of the proposed&#13;\ngeneral dynamic, furthermore, the dynamic covers the supervised case&#13;\nof recurrent and recursive networks, too. The general framework&#13;\noffers a uniform notation for training mechanisms such as Hebbian&#13;\nlearning and the transfer of alternatives such as vector quantization&#13;\nor the neural gas algorithm to structure processing networks. The&#13;\nformal definition of the recursive dynamic for structure processing&#13;\nunsupervised networks allows the transfer of theoretical issues from&#13;\nthe SOM literature to the structure processing case. One can&#13;\nformulate general cost functions corresponding to vector quantization,&#13;\nneural gas, and a modification of SOM for the case of structures. The&#13;\ncost functions can be compared to Hebbian learning which can be&#13;\ninterpreted as an approximation of a stochastic gradient descent. We&#13;\nderive as an alternative the exact gradients for general cost&#13;\nfunctions which can be computed in several ways similar to well-known&#13;\nlearning algorithms for supervised recurrent and recursive networks.&#13;\nWe afterwards discuss general design issues which should be taken into&#13;\naccount when choosing internal representations and which limit the&#13;\napplicability of specific choices in concrete situations: We&#13;\ninvestigate the necessary cardinality of the set of internal&#13;\nrepresentations, the tolerance with respect to noise, and the&#13;\nnecessary of globality of processing. Finally, we discuss the issue&#13;\nof topology preservation of structure processing self-organizing maps&#13;\nand derive an explicit metric for a specific situation for SOMSD.
Radar Communication for Combating Mutual Interference of FMCW Radars (2018)

Commercial automotive radars used today are based on frequency modulated continuous wave signals due to the simple and robust detection method and good accuracy. However, the increase in both the number of radars deployed per vehicle and the number of such vehicles leads to mutual interference among automotive radars, and cutting short future plans for autonomous driving and safety. We propose and analyze a radar communication (RadCom) approach to reduce or eliminate this mutual interference while simultaneously offering communication functionality. Our RadCom approach frequency division multiplexes radar and communication, where communication is built on a decentralized carrier sense multiple access protocol and is used to adjust the timing of radar transmissions. Our simulation results indicate that radar interference can be significantly reduced, at no cost in radar accuracy.
Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum (2022)

Abstract Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and haematological parameters in both pre-clinical animal models and humans. We studied mouse experimental visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani in BALB/c mice using dual RNA-seq to investigate the transcriptional response of host and parasite in liver and spleen. We identified only 4 species-specific parasite expressed genes (SSPEGs; log2FC &gt;1, FDR &lt;0.05) in the infected spleen, and none in the infected liver. For the host transcriptome, we found 789 differentially expressed genes (DEGs; log2FC &gt;1, FDR &lt;0.05) in the spleen that were common to both infections, with IFNγ signaling and complement and coagulation cascade pathways highly enriched, and an additional 286 and 186 DEGs that were selective to L. donovani and L. infantum infection respectively. Among those, there were network interactions between genes of amino acid metabolism and PPAR signaling in L. donovani infection and increased IL1β and positive regulation of fatty acid transport in L. infantum infection, although no pathway enrichment was observed. In the liver, there were 1939 DEGs in mice infected with either L. infantum or L. donovani in comparison to uninfected mice, and the most enriched pathways were IFNγ signaling, neutrophil mediated immunity, complement and coagulation, cytokine-chemokine responses and hemostasis. Additionally, 221 DEGs were selective in L. donovani and 429 DEGs in L. infantum infections. These data show that the host response for these two visceral leishmaniasis infection models is broadly similar, and ∼10% of host DEGs vary in infections with either parasite species. Importance Visceral leishmaniasis (VL) is caused by two species of Leishmania parasites, L. donovani in the Old World and L. infantum in the New World and countries bordering the Mediterranean. Although cardinal features such as hepato-splenomegaly and alterations in blood and immune function are evident, clinical presentation may vary by geography, with for example severe bleeding often associated with VL in Brazil. Although animal models of both L. donovani and L. infantum have been widely used to study disease pathogenesis, a direct side-by-side comparison of how these parasites species impact the infected host and/or how they might respond to the stresses of mammalian infection has not been previously reported. Identifying common and distinct pathways to pathogenesis will be important to ensure that new therapeutic or prophylactic approaches will be applicable across all forms of VL.
CMV‐specific central memory T cells reside in bone marrow (2007)

CMV-specific CD8(+) T cell responses in peripheral blood (PB) are characterized by a preponderance of effector and effector memory T cells. CMV-specific central memory T cells (T(CM)), which are considered crucial in maintaining long-term immunity, are rarely detectable in PB. In this study we have analyzed differentiation and function of CMV pp65-specific CD8(+) T cells in paired samples of human PB and BM using intracellular cytokine and tetramer staining. Overall frequencies of CMV pp65-specific T cells were similar in PB compared to BM; however, CMV-specific CD45RA(-)CCR7(+) T(CM) were almost exclusively detectable in BM, which was not related to a general accumulation of T(CM) in BM. In vitro, CMV-specific T cells could be more efficiently expanded from BM (median 128-fold, n=6) than from PB (median 72-fold, p=0.01). Taken together, these data show that the BM is a compartment harboring CMV-specific T(CM) and underline the concept of the BM as a secondary immune organ. CMV specific BM-derived T(CM) might be a valuable source for generating T cells for adoptive transfer.
LBODP081 The Relationship Between Body Mass Index Changes And Bone Age Progression During Gonadotropin-releasing Hormone Agonist Treatment In Girls With Idiopathic Central Precocious Puberty (2022)

Abstract Purpose To analyze the relationship between body mass index change and bone age progression during gonadotropin-releasing hormone agonist(GnRHa) treatment in girls with idiopathic central precocious puberty Methods: 65 girls with idiopathic central precocious puberty who are treated with GnRHa more than 2 years were retrospectively reviewed. Height, weight, Tanner stage, bone age were measured every 6 months from the start of treatment. The degree of obesity was evaluated using the body mass index (BMI) standard deviation score (SDS), and the relationship between the change in obesity and the progression of bone age was analyzed. Overweight was defined as a BMI greater than or equal to the 85th percentile. The chronological age at the start and the end of treatment was 7. 00±0. 00 years and 10.63±0.50 years in the overweight group (16 patients), and 6.86±0.35 years and 10.71±0.54 years in the other group (49 patients), respectively. Results There was no difference in bone age between the normal weight group and the overweight group at the start of treatment (9.85±0.57 years vs 10. 04±0.73 years, P=0.263). Bone age was higher in the overweight group, but after 1 year of treatment, 2 years of treatment, and at the end of treatment, the overweight group had a higher bone age than the normal weight group (10.47±0.56 years vs 10.87±0.57 years, P=0. 02; 11. 06±0.47 years vs 11.46±0.51 years, P=0. 004; 11.70±0.46 years vs 12. 01±0.52 years, P=0. 03). Bone age at the end of treatment was related to overweight at the start of treatment (r=0.265, P=0. 03) and the increase in BMI SDS from normal to overweight during treatment (r=0.285, P=0. 02). There were 11 children (17%) whose BMI SDS increased from normal to overweight during treatment, compared with the other patients, there was no difference in bone age during 2 years of treatment, but bone age at the end of treatment was higher (12. 09±0.60 years vs 11.71±0.47 years, P=0. 02), and the difference in bone age before and after treatment was also greater (2.31±0.68 years vs 1.79±0.52 years, P=0. 01). Linear regression analysis demonstrated that the increase in BMI SDS from normal to overweight during treatment had a positive correlation with bone age at the end of treatment (β=0.31, R2=0. 07, P=0. 03). Conclusion In girls with central precocious puberty, an increase in obesity from normal to overweight during GnRHa treatment does not affect bone age progression until 2 years from the start of treatment, but might be a risk factor for bone age progression at the end of treatment. Presentation: No date and time listed
Assessment of functional conditions of basketball and football players during the load by applying the model of integrated evaluation. (2010)

The newly deduced parameters, namely, speeds of changes in the parameters with changes in the phase of the load reflect very well peculiarities of functional condition of the human body during bicycle ergometry test. The sum total of those newly deduced parameters and customary parameters reveals new functional peculiarities of the human body.
Uruguay: Political and Economic Conditions and U.S. Relations (2010)

This report examines recent political and economic developments in Uruguay as well as issues in U.S.-Uruguayan relations.
Morphology of ABC triblock copolymer/homopolymer blend systems (2002)

Abstract Morphological variations of ABC triblock copolymers through the blending of B or A/C homopolymers, all with short chain lengths, were studied experimentally. The samples were symmetric ISP triblock copolymers, where I, S, and P denote polyisoprene, polystyrene, and poly(2‐vinylpyridine), and component homopolymers. Microphase‐separated structures of the solvent‐cast films were observed with transmission electron microscopy and small‐angle X‐ray scattering. For an ISP/S system, the lattice constant of the tricontinuous gyroid structure (G‐structure) increased with an increase in the volume fraction of S (ϕ s ) if the amount of added homopolymer was small, but it reached a certain limit, reflecting the fact that the midblock chain had a limit for chain stretching. For I/ISP/P blends, on the contrary, the lattice constant of the G‐structure continued increasing with decreasing ϕ s . This result shows that the I and P domains did not have a limit for chain stretching because the two end blocks had free ends. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 1135–1141, 2002