gebhart/patrepeval huggingface dataset:
Implementing a Production Schedule at LKAB's Kiruna Mine (2004)

LKAB's Kiruna Mine, located in northern Sweden, produces about 24 million tons of iron ore yearly using an underground mining method known as sublevel caving. To efficiently run the mills that process the iron ore, the mine must deliver planned quantities of three ore types. We used mixed-integer programming to schedule Kiruna's operations, specifically, which production blocks to mine and when to mine them to minimize deviations from monthly planned production quantities while adhering to operational restrictions. These production schedules save costs compared to schedules produced manually by meeting desired production quantities more closely and reducing employee time spent on preparing schedules.
Hernia-repair prosthetic devices functionalised with chitosan and ciprofloxacin coating: controlled release and antibacterial activity (2014)

Polypropylene nets are widely used as hernioplasty prostheses. The reproduction of bacteria within the net fibers intersections can occur after the application of the prosthesis causing infections. For this reason, bacteria have to be removed in the very early stage of surgical implantation. Activation of the prosthesis surface was done by an innovative oxidizing plasma treatment (APP-DBD) working under atmospheric conditions in order to favor the deposition of an antibacterial coating of chitosan (biocompatible carbohydrate) and ciprofloxacin (broad spectrum antibiotic). Two different coating mixtures were realised and the antibacterial properties of such functionalised nets were investigated, together with their effectiveness. Physico-chemical characterisations of meshes were carried out before and after functionalisation by SEM-EDS and infrared spectroscopy. The release of both chitosan and ciprofloxacin, under controlled experimental conditions, was followed respectively by colorimetric determination (using UV-Visible spectroscopy) and chromatographic analysis (using HPLC). In vitro tests allow verifying antimicrobial activity (inoculation of specimens in a Staphylococcus aureus suspension).
Objective video quality assessment for mobile application (2006)

In this paper, the objective video quality assessment has been used to the mobile application. We propose a set of objective video quality assessment model to evaluate the video transmission quality over a wireless channel. By this way, we can rate the quality of the multimedia wireless transmission more objectively and economically. This objective video quality assessment model can be sensible to most of the usual video distortion and have good correlation with the subjective assessment. (4 pages)
Unexpected Entrance-Channel Effects in the Decay of the Compound NucleusEr156 (1986)

Angular momentum distributions for the dominant decay channels of $^{156}\mathrm{Er}$ compound nuclei have been studied with the Darmstadt-Heidelberg "crystal ball" detector in nearly mass-symmetric ($^{64}\mathrm{Ni}$+$^{92}\mathrm{Zr}$) and asymmetric ($^{12}\mathrm{C}$+$^{144}\mathrm{Sm}$) entrance channels. Strong differences in the $\ensuremath{\alpha}n$ yield and $\frac{{2}_{n}}{{3}_{n}}$ cross-section ratios are observed at the same excitation energy (47 MeV) and spin in $^{156}\mathrm{Er}$. This effect indicates that there is memory of the entrance channel during the particle-evaporation stage of the compound-nucleus decay. The dominant exit channels do not exhibit high-angular-momentum components.
Metabolic Studies on CS-670, A New 2-Arylpropionic Acid Nonsteroidal Anti-inflammatory Drug. (1). Absorption, Metabolism and Excretion of 14C-CS-670 in Mice, Rats and Dogs. (1995)

14C-CS-670 をラット，マウスおよびイヌに経口投与し吸収，代謝および排泄を検討した．1．マウスに 10mg/kg 経口投与後の血漿中総放射能濃度のTmax は15分，Cmax は 15.8μg/mlで，2時間までのT1/2は 0.41時間であった．血漿中に未変化体は極微量しか存在せず，主代謝物としてcis-OH 体が検出された．2．マウスにおける48時間までの排泄率は尿中に 77.3%，糞中に 14/1% であった．尿中主代謝物は cis-OH 体および trans-OH 体のグルクロソ酸抱合体であった．3．雄性ラットに 2mg/kg 投与後の血液中放射能濃度の Tmax は30分，Cmax は 1.70μg/ml，3時間までの T1/2 は 1.47時間であった．雌性ラットにおけるTmax，Cmax，T1/2 はそれぞれ 30分，3/52μg/ml，2.81時間であった．血漿中に未変化体は非常に少なく，主代謝物として trans-OH 体が検出された．ラット血漿中 trans-OH 体の濃度に，雄性は雌性より低いという性差が認められた．4．雄性ラットでは144時間までの尿中に 72.5%，糞中に 20.7% の放射能が排泄された．雌性ラットでは尿中に 76.7%，糞中に 17.6% が排泄された．尿中主代謝物はジオール体で，雌性(尿中の67.8%)に比べ雄性ラット(尿中の92.8%)で多かった．5．雄性ラットにおける胆汁排泄率は69．5%，再吸収率は 89.5% であった。胆汁中には主に trans-OH 体のグルクロソ酸抱合体として排泄された．6．雄性イヌに 2mg/kg 経口投与後の血漿中 Tmax，Cmax および6時間までのT1/2 はそれぞれ1時間，4.87μg/ml および2.16 時間であった。雌性イヌにおける対応する値は2時間，4.09μg/ml，2.21時間であった．7．雄性イヌでは120時間までの尿中に 57.9%，糞中に 38.9% の放射能が排泄された．雌性イヌでは尿中に 60.6%，糞中に 32.3% が排泄された．尿中主代謝物は雌雄ともにアミノ酸抱合体と推定される極性の強い代謝物で尿中の70-80%を占めていた．8．マウス，ラットおよびイヌにおける CS-670 の代謝には顕著な種差が観察された．すなわち，いずれの動物でも CS-670 の二重結合が速やかに還元されたのち，ケトン基が還元されラットおよびイヌでは trans-0H 体が，マウスでは cis-OH 体が主に生成するが，それらモノオール体をラットはジオール体として，マウスはグルクロン酸抱合体として，またイヌはアミノ酸抱合体と推定される代謝物として尿中に排泄した．さらに，ラットではジオール体の生成に雌性に比べ雄性で多いという性差が認められた．
Synthesis of New Donor-functionalized Alcohols as Organic Ligands for Metal Precursors of Metal Organic Chemical Vapor Deposition (2005)

2] Generalization to prepare organic ligands for MOCVD precursors is especially
Real‐time biofeedback integrated into neuromuscular training reduces high‐risk knee biomechanics and increases functional brain connectivity: A preliminary longitudinal investigation (2020)

Prospective evidence indicates that functional biomechanics and brain connectivity may predispose an athlete to an anterior cruciate ligament injury, revealing novel neural linkages for targeted neuromuscular training interventions. The purpose of this study was to determine the efficacy of a real-time biofeedback system for altering knee biomechanics and brain functional connectivity. Seventeen healthy, young, physically active female athletes completed 6 weeks of augmented neuromuscular training (aNMT) utilizing real-time, interactive visual biofeedback and 13 served as untrained controls. A drop vertical jump and resting state functional magnetic resonance imaging were separately completed at pre- and posttest time points to assess sensorimotor adaptation. The aNMT group had a significant reduction in peak knee abduction moment (pKAM) compared to controls (p = .03, d = 0.71). The aNMT group also exhibited a significant increase in functional connectivity between the right supplementary motor area and the left thalamus (p = .0473 after false discovery rate correction). Greater percent change in pKAM was also related to increased connectivity between the right cerebellum and right thalamus for the aNMT group (p = .0292 after false discovery rate correction, r<sup>2</sup> = .62). No significant changes were observed for the controls (ps > .05). Our data provide preliminary evidence of potential neural mechanisms for aNMT-induced motor adaptations that reduce injury risk. Future research is warranted to understand the role of neuromuscular training alone and how each component of aNMT influences biomechanics and functional connectivity.
Design and additive manufacturing of multi-permeability magnetic cores (2017)

Uneven distribution of magnetic flux in a conventional magnetic core limits improvement of power density of the magnetic component. By making a magnetic core comprising materials with different permeabilities, henceforth called multi-permeability core, a more uniform flux distribution can be achieved without complex configuration and geometry of the core and winding. In this work, we designed a three-ring toroid core to produce a flux uniformity factor, α, defined as B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">min</sub> /B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> , in each of the three rings by increasing permeability from inner to outer ring. With the same inductance, volume of the three-permeability toroid core was significantly smaller than that of a single-permeability toroid core. For ease of fabricating multi-permeability magnetic cores, a commercial multi-extruder paste-extrusion 3D printer was explored to process different magnetic pastes into 3D structures. The magnetic pastes were formulated in our laboratory. Two types of magnetic paste systems, a high-temperature (> 900°C) pressure-less sinterable ferrite and a low-temperature (<; 250°C) pressure-less curable powdered-iron, were developed and tested in the 3D printer. By varying the magnetic/organic composition in each of the two material systems, we produced pastes that are compatible with the 3D printer and can be processed into core materials with relative permeability ranging from 20 to 70. With the same dimensions, a 3D-printed three-permeability toroid core had a higher inductance than a single-permeability core.
Sleep-disordered Breathing in Newborn Mice Heterozygous for the Transcription Factor Phox2b (2005)

Although their respiratory phenotype was much less severe than CCHS, the Phox2b(+/-) mutant mice showed sleep-disordered breathing, which partially modeled the key feature of CCHS.
A Universal Panel Tester (1995)

Abstract A universal panel tester was built at the University of Houston to test reinforced concrete panel elements subjected to any combination of in-plane and out-of-plane forces. The forces are applied by 40 in-plane hydraulic jacks of 250-kip (1120-kN) capacity each and 20 out-of-plane hydraulic jacks of 140-kip (630-kN) capacity. The sophisticated hydraulic system makes it possible to simulate any complex stress condition in a panel.
Atmospheric spatial atomic layer deposition of ZnOS buffer layers for flexible Cu(In,Ga)Se2 solar cells (2018)

Zinc oxysulfide (ZnOS) is synthesized at atmospheric pressure in a laboratory-scale spatial atomic layer deposition setup by sequentially exposing the substrate to diethyl zinc and an H2O/H2S mixture, separated by a nitrogen gas curtain. The co-injection of H2O and H2S vapors in the same deposition zone enables an accurate control of the S/(O + S) ratio, the morphology, and the optoelectronic properties of the films. Next, the ZnOS deposition process is transferred to an industrial roll-to-roll spatial-ALD setup. ZnOS is applied as a buffer layer in flexible Cu(In,Ga)Se2 solar cells, instead of the commonly used CdS, achieving a best efficiency of typically 13% in small area cells (0.57 cm2) and 9.2% in flexible mini-modules (270 cm2). These results show the viability of atmospheric spatial-ALD as a new technique for roll-to-roll manufacturing of flexible photovoltaics modules based on a Cu(In,Ga)Se2 absorber.
High Rate Biomethanation of Carbon Monoxide-Rich Gases via a Thermophilic Synthetic Coculture (2017)

Carbon monoxide-fermenting microorganisms can be used for the production of a wide range of commodity chemicals and fuels from syngas (generated by gasification of, e.g., wastes or biomass) or industrial off-gases (e.g., from steel industry). Microorganisms are normally more resistant to contaminants in the gas (e.g., hydrogen sulfide) than chemical catalysts, less expensive and self-regenerating. However, some carboxydotrophs are sensitive to high concentrations of CO, resulting in low growth rates and productivities. We hypothesize that cultivation of synthetic cocultures can be used to improve overall rates of CO bioconversion. As a case study, a thermophilic microbial coculture, consisting of <i>Carboxydothermus hydrogenoformans</i> and <i>Methanothermobacter thermoautotrophicus</i> was constructed to study the effect of cocultivation on conversion of CO-rich gases to methane. In contrast to the methanogenic monoculture, the coculture was able to efficiently utilize CO or mixtures of H<sub>2</sub>/CO/CO<sub>2</sub> to produce methane at high efficiency and high rates. In CSTR-bioreactors operated in continuous mode, the coculture converted artificial syngas (66.6% H<sub>2</sub>:33.3% CO) to an outflow gas with a methane content of 72%, approaching the 75% theoretical maximum. CO conversion efficiencies of 93% and volumetric production rates of 4 m<sup>3</sup><sub>methane</sub>/m<sup>3</sup><sub>liquid</sub>/day were achieved. This case shows that microbial cocultivation can result in a significant improvement of gas-fermentation of CO-rich gases.
The Use of Virtual Reality Technology in the Treatment of Anxiety and Other Psychiatric Disorders (2017)

After participating in this activity, learners should be better able to:• Evaluate the literature regarding the effectiveness of incorporating virtual reality (VR) in the treatment of psychiatric disorders• Assess the use of exposure-based intervention for anxiety disorders ABSTRACT: Virtual reality (VR) allows users to experience a sense of presence in a computer-generated, three-dimensional environment. Sensory information is delivered through a head-mounted display and specialized interface devices. These devices track head movements so that the movements and images change in a natural way with head motion, allowing for a sense of immersion. VR, which allows for controlled delivery of sensory stimulation via the therapist, is a convenient and cost-effective treatment. This review focuses on the available literature regarding the effectiveness of incorporating VR within the treatment of various psychiatric disorders, with particular attention to exposure-based intervention for anxiety disorders. A systematic literature search was conducted in order to identify studies implementing VR-based treatment for anxiety or other psychiatric disorders. This article reviews the history of the development of VR-based technology and its use within psychiatric treatment, the empirical evidence for VR-based treatment, and the benefits for using VR for psychiatric research and treatment. It also presents recommendations for how to incorporate VR into psychiatric care and discusses future directions for VR-based treatment and clinical research.
Real-world treatment of hepatitis C with second-generation direct-acting antivirals: initial results from a multicentre Canadian retrospective cohort of diverse patients (2018)

We report high SVR rates in a real-world diverse cohort of HCV-infected patients treated with second-generation direct-acting antivirals. The results highlight the importance of conducting real-world analyses to elucidate clinical factors associated with poorer outcomes that may not be identified in registration trials.
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. (1994)

Deregulated expression of cyclin D1 is a feature of several neoplastic and proliferative disorders, but its normal role in the cell cycle remains unclear. Here we show that in a squamous carcinoma cell line with 11-fold amplification of the CCND1 gene, cyclin D1 associates specifically with p33cdk4 (PSK-J3) and p38cdk6 (PLSTIRE), two closely related members of the cyclin-dependent kinase (CDK) family. In these tumour cells, there is little evidence for an association between cyclin D1 and other CDKs, but in diploid human fibroblasts both CDK2 and CDK5 can be co-precipitated with cyclin D1, as well as CDK4. The data suggest that D-type cyclins participate in multiple interactions with CDKs but that the nature or stoichiometry of these associations may differ in different types of cell.
Near-Optimal Trajectory Planning of a Spherical Mobile Robot for Environment Exploration (2008)

Spherical mobile robot has the characteristics of compact structure and agile motion and is promising to be used in unmanned environment. Designed for environment exploration, a spherical mobile robot BHQ-2 was briefly introduced. The kinematic equation of BHQ-2 was established and its controllability was proved with controllable Lie algebra. Based on the Ritz approximation theory, the near-optimal trajectory of BHQ-2 was planned with the Gauss-Newton algorithm. Simulation results and experimental results of the spherical mobile robot to plan trajectory with the method were presented.
Abstract 3195: Intratumoral electroporation of plasmid IL-12 and CXCL9 with membrane-bound anti-CD3 elicits robust anti-tumor immunity (2019)

Abstract Preclinical and clinical studies have demonstrated that plasmid IL-12 (tavokinogene telseplasmid) delivered intratumorally via electroporation (TAVO) induces local expression of IL-12p70, converting immunologically excluded tumors into inflamed immunogenic lesions, which is fundamental to generating objective responses in both treated and untreated distant tumors. Recent optimization of electroporation parameters and plasmid design has yielded a significant increase in intratumoral expression and anti-tumor efficacy in preclinical models. To further develop this platform, longitudinal biomarker data from TAVO clinical trials was interrogated to identify key immunological components associated with an effective therapy. This analysis revealed that the composition of TAVO-inflamed lesions, specifically the frequency of CD8+ TIL and the chemokines necessary for their maintenance relative to suppressive intratumoral immune subsets, coincided with clinical responses. We therefore developed a plasmid that encodes both IL-12 and the effector T cell chemokine, CXCL9, which, when transfected into a tumor, are functionally active both in vitro as well as in vivo, yielding abscopal responses and increased survival. To further amplify this technology, a strategy was developed to engage the highly relevant and recently described bystander non-tumor reactive T cells in the tumor microenvironment (TME). To accomplish this pan-T cell amplification, a separate therapeutic plasmid encoding membrane-bound anti-CD3 scFv (145-2C11) was used to decorate transfected tumors with the potent polyclonal T cell stimulator. Membrane expression of anti-CD3 in vivo was confirmed by immunoblot and flow cytometry. Combination of IL-12/CXCL9 with anti-CD3 delivered by electroporation (collectively, “SPARK”) increased both antigen-specific and polyclonal T cells responses, demonstrated by in vivo CTL and proliferation assays. Finally, SPARK upregulated the transcription of key immunological genes, leading to regression of both treated and untreated tumors, which heightens its ability to reshape the TME and drive systemic anti-tumor immunity. In conclusion, this data supports a model whereby IL-12 in concert with CXCL9 inflames the lesion, leading to a brisk T cell infiltrate, which in sequence with anti-CD3 stimulation, drives a broad yet robust systemic T cell response. SPARK represents a significant advancement in cytokine-based immunotherapy. Note: This abstract was not presented at the meeting. Citation Format: Mia Han, Anandaroop Mukhopadhyay, Bianca Nguyen, Kurt Sakurada, Jack Lee, David A. Canton, Christopher G. Twitty. Intratumoral electroporation of plasmid IL-12 and CXCL9 with membrane-bound anti-CD3 elicits robust anti-tumor immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3195.
Toxicity evaluation of personal care and household products as silent killers on the survival of Daphnia magna (2021)

Daphnia magna (D. magna) is highly sensitive to pollutants and act as a model bioindicator organism in ecotoxicology. Taking this added-value of D. magna, herein, we tested acute toxicity in the crustacean against a range of domestic products that are subsequently drained into the water streams. Sequentially, the sensitivity of the organisms towards tested products was found in the order of (from most toxic to least toxic) toilet cleaner = glassware washing liquid > detergent > liquid hand wash > shampoo > raw mustard oil > cooked mustard oil > refined oil > diatomaceous earth. We calculated LC0, LC50, and LC99 values for toxicity bioassays against detergent, liquid hand wash and shampoo for ten days. The result showed that 100% females’ mortality was achieved in detergent at a concentration of 4g/l and hand washing sanitizer at 4.35 g/l in 6 days, respectively. On the other hand, 50% and 17% mortality were observed in shampoo (2.5 and 3.5 g/l) and control (4.35g/l) in 8 days each, respectively. The result has shown the dose-dependent toxicity of various household products on D. magna.
An Experimental Study of a New VES Acid System: Considering the Impact of CO2 Solubility (2011)

Abstract Viscoelastic surfactant (VES) based self-diverting acid system has been developed for better matrix treatment of carbonate formations. Literature survey indicates that the highly viscous fluid acts as a temporary barrier to reduce further fluid loss into the wormholes and allows complete stimulation of all treating zones. After acid treatment, the viscous fluid is broken by either formation hydrocarbons or pre-flush fluids. However, recent lab work confirmed that a significant amount of surfactant was retained inside the core even when mutual solvent was used. The present study was conducted to better understand these acid systems and determine factors that impact their viscosity build-up and performance inside the carbonate formations. A series of coreflood tests were conducted using low and high permeability carbonate cores at different injection rates. Propagation of the acid, surfactant, and reaction products inside the cores was examined in detail. Samples of the core effluent were collected and the concentrations of calcium, surfactant, and acid were measured. Permeability enhancement and location of any precipitation was detected using CT scanner to the core before and after the acid injection. Material balance was conducted to determine the amount of surfactant that retained in the core. Experimental results show that VES acid was only able to build pressure drop across the core at injection rates less than 1 cm3/min when it was injected inside 80 md permeability cores. However, at injection rates of 1 cm3/min and higher, VES was not able to build any pressure drop across the core when it was injected into 4 md cores. Acid pore volume to breakthrough and amount of VES retained in the core were reduced when low permeability cores were used. Calcium propagated faster than HCl, while surfactant propagated the same rate as HCl. Also, pore volume needed to breakthrough the calcium and the maximum calcium concentrations were independent of the acid injection rate. CT scan confirmed that wormhole branches were observed at the second half of the core. At ambient conditions: viscosity of live VES acid was higher than that of partially neutralized (pH 4.5). At temperatures greater than 140oF, the viscosity of partially neutralized acid was higher than the live acid. G’ of the live VES acid was dominant at ambient temperature, while when temperature increased to 85oF, G"became the dominant characteristics of the live VES acid.
ChemInform Abstract: Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Barbier Cyclization/Grob Fragmentation for the Synthesis of Medium‐Sized Carbocycles. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Radio Propagation above 40 MC over Irregular Terrain (1957)

Radio transmissions in the vhf and uhf frequency region over land areas always contend with the irregularities of the terrain and the presence thereon of dispersed quantities of trees, buildings, and other man-made structures, or wave propagation incumbrances. The determination of path attenuation is not easily satisfied by simple, curved, or plane earth calculations. However, quantitative wave propagation data are available in varying degrees which take into account conditions experienced by fixed-to-fixed and fixed-to-moving transmissions over irregular terrain. This available statistical wave propagation information on terrain effects vs frequency, antenna height, polarization, and distance is analyzed, expressed by empirical formulas, and presented in the form of nomographs and correction curves amenable for use by the systems engineer.