gebhart/patrepeval huggingface dataset:
Synthesis and Screening of a Molecularly Imprinted Polymer Library Targeted for Penicillin G (2002)

A library of molecularly imprinted polymers (MIPs) was synthesized by radical bulk polymerization using the beta-lactam antibiotic penicillin G as the template. Diversity of the library was obtained by combining various functionalized monomers and cross-linkers and by varying the stoichiometry and the concentration of the components in the prepolymerization mixtures. The library was screened for selectivity to penicillin G by a radioligand binding assay and was compared to a corresponding control library. The best MIP candidate, showing the highest selectivity for penicillin G, was prepared from methacrylic acid and trimethylolpropane trimethacrylate as the functionalized monomer and cross-linker, respectively. Cross-reactivity studies with other beta-lactam antibiotics showed a low cross-reactivity of penicillin V (15%), ampicillin (16%), and amoxicillin (19%). Nafcillin and oxacillin showed less cross-reactivity (<1%). Cross-reaction with a cephalosporin antibiotic (cephapirin) and structurally nonrelated antibiotics (chloramphenicol, tetracycline, dapsone, and erythromycin) was less than 0.01%.
High performance Liquid Chromatography를 이용한 실리콘 하이트로겔렌즈의 지방 침전물 분석 (2010)

목적: In vitro 조건 하에서 재질이 다른 실리콘 하이드로겔 렌즈에 결합되는 눈물의 지방성분인 올레산(oleic acid), 올레산에스테르(oleic acid methyl ester) 및 콜레스테롤(cholesterol)을 각각 정량하여 실리콘 하이드로겔렌즈에 부착되는 지방침전물을 비교하였다. 방법: Lotrafilcon A, lotrafilcon B, galyficon A 및 balafilcon A 재질의 실리콘 하이드로겔 렌즈와polymacon 렌즈 및 RGP 렌즈를 올레산, 올레산에스테르 및 콜레스테롤을 동일한 양 포함하는 식염수 용액에 담가 37℃에서 흔들어주면서 24시간 동안 오염시킨 후, methanol과 chloroform을 1:1(v/v) 비율로 포함하는 유기용매를 이용하여 4시간 동안 렌즈에 부착된 지방을 추출하였다. 추출된 지방은 C-18 column을 사용하여 HPLC(high performance liquid chromatography)를 수행하여 분리하고 정량하였다. 결과: 실리콘 하이드로겔렌즈에 부착된 지방의 총량은 재질의 종류에 따라 48~67 ㎍/lens, polymacon 렌즈와 RGP 렌즈에서는 각각 18 ㎍/lens, 177 ㎍/lens로 측정되어, 실리콘 하이드로겔렌즈의 지방 부착량은 polymacon 소프트렌즈의 300~372%, RGP 렌즈의 30.5~37.8%로 나타났다. 지방침전물은 galyfilcon A 재질에 가장 많이 부착되었으며(p<0.001), balafilcon A, lotrafilcon A 및 B 재질에 부착된 지방침전물은 유의한 차이가 없었다. 세 종류의 지방 성분 중 올레산이 모든 실리콘 하이드로겔렌즈와 polymacon 소프트렌즈 및 RGP 렌즈에 가장 많이 부착되었다. 결론: In vitro 상태에서 실리콘 하이드로겔렌즈에 부착되는 지방침전물의 양은 polymacon 소프트렌즈 보다 많고 RGP 렌즈보다는 적었으며, 실리콘 하이드로겔렌즈의 재질에 따라서도 지방 침전물양은 차이가 있는 것으로 평가되었으며, 본 연구 결과는 실리콘 하이드로겔렌즈의 세척액 개발에 기초자료로 활용될 수 있을 것으로 사료된다.
MPC-On-Chip: An Embedded GPC Coprocessor for Automotive Active Suspension Systems (2010)

Safety critical automotive systems require tight real-time constraints. This letter presents a case study for embedded implementation of a model predictive controller (MPC) used to control an automotive active suspension system. It proposes a special purpose coprocessor for solving the online mathematical optimization needed by the controller, while maintaining real-time constraints imposed by system dynamics. Mathematical formulation for the optimum usage of hardware resources is provided and verified for its applicability on a proposed platform.
DESIGNING ULTRASENSITIVE AND STRECHABLE STRAIN SENSORS BY TAILORED FRAGMENTATION OF CARBON-BASED CONDUCTORS (2017)

Stretchable sensors are needed for emerging applications such like wearable electronics, artifical e-skins. They shoudl show good perfromance in�sensitivity, stretchability and linearity.�Our strategy here is to develop a new family of sensors taking advantage of the special properties of�fragmented carbon-nanoparticles based geometries.�Our concept could readily be extended to�other conductive nano materials, paving the way for developing high-performance strain sensors.
Advanced Methods for Treatment of Organic Compounds Contamined Water (2009)

The progress recorded in the field of science and advanced engineering at nanometric scale supplies large
opportunities for more efficient (from the point of view of the costs) and more ecological approach of the processes of
water purifying. This paper delivers a short description of the possibilities of using advanced materials in purifying the
contamined water with toxic metallic ions, organic and anorganic compounds. The opportunities and challenges were
also emphasized when nanomaterials were used for the surface, underground and industrial used waters treatment.
Celebrating 30 years of ART in Latin America; and the 2018 report (2021)

The Latin American Registry of Assisted Reproduction (RLA) celebrates 30 years of voluntary reporting from a total of nearly 200 centres in 15 countries. This South-South Cooperation network has proven to be an efficient and safe system for technological transfer and regional growth.
Delamination of polyimide in hydrofluoric acid (2021)

Wet etching is a critical fabrication step for the mass production of micro and nanoelectronic devices. However, when an extremely corrosive acid such as hydrofluoric (HF) acid are used during etching, an undesirable damage might occur if the device includes a material that is not compatible with the acid. Polyimide thin films can serve as sacrificial/structural layers to fabricate freestanding or flexible devices. The importance of polyimide in microelectronics is due to its relatively low stress and compatibility with standard micromachining processes. In this work, a fast delamination process of a 4-μm-thin film of polyimide from a silicon substrate has been demonstrated. The films’ detachment has been performed using a wet-based etchant of HF acid. Specifically, the effect of HF concentration on the delamination time required to detach the polyimide film from the substrate has been investigated. This study is intended to provide the information on the compatibility of using polyimide films with HF, which can help in the design and fabrication of polyimide-based devices.
Analysis of Very Large Dual-Reflector Antennas Using Multilevel Physical Optics (MLPO) Algorithm (2007)

This paper demonstrates the performance attainable using the MLPO algorithm for very large dual reflector antennas.
αDecay of Neutron-Deficient Isotopes of Bismuth and Lead Produced in (Ar,xn) and (Kr,xn) Reactions (1972)

Neutron-deficient isotopes of bismuth and lead have been produced in various heavy-ion---induced reactions. Argon and krypton ions were used as projectiles on $^{159}\mathrm{Tb}$, $^{155}\mathrm{Gd}$, and $^{109}\mathrm{Ag}$. We observed $\ensuremath{\alpha}$ emission from bismuth nuclides and isomers with $A=190\ensuremath{-}197$ and from lead isotopes with $A=186\ensuremath{-}190$. We give results on mass assignments, $\ensuremath{\alpha}$-decay energies, half-lives, and $\ensuremath{\alpha}$ branching ratios. Two new lead isotopes were found: $^{187}\mathrm{Pb}$, ${E}_{\ensuremath{\alpha}}=6.08$ MeV, ${t}_{\frac{1}{2}}=17.5$ sec; and $^{186}\mathrm{Pb}$, ${E}_{\ensuremath{\alpha}}=6.32$ MeV, ${t}_{\frac{1}{2}}=7.9$ sec. No $\ensuremath{\alpha}$-emitting isotopes of thallium were found, and upper limits significantly below 1% can be set on the $\ensuremath{\alpha}$ branching ratios of T1 isotopes with $A=182\ensuremath{-}187$.
STUDIES ON TRACE ANALYSIS OF URANIUM BY LASER INDUCED FLUORESCENCE SPECTROMETRY II. THE DETERMINATION OF TRACE URANIUM IN PHOSPHORIC ACID AND PHOSPHATE SOLUTIONS (1983)

The determination of trace uranium in phosphoric acid and phosphate, solutions by means of the laser induced fluorescence method is investigated, with detailed study on the intensity and lifetime of uranium fluorescence in ortho-phosphoric acid, ortho-phos-. phate, meta-phosphate and pyro-phosphate media. Ortho-phosphoric acid enhances the fluorescence intensity more strongly than sulfuric acid or sulphate. The intensity of uranium fluorescence increases with an increase of phosphoric acid concentration, and a saturation value of intensity is reached when the concentration exceeds 1 M. The fluorescence intensity of uranium in phosphoric acid solu- tion can be enhanced with the addition of ammonium phosphate which is best suited for fluorescence enhancement.The detection limit of uranium is 0.02 ppb in 0.3 M H3PO4-1.0M NH4H2PO4 medium, and better than 0.01 ppb in 0.01 M Na4P2O7-pH 7.2 phosphate buffer medium.The lifetime of uranium fluorescence is 216 μs in orthophosphoric acid medium and about 50μs in ammonium phosphate or sodium pyro-phosphate medium. When the medium is fixed, the fluorescence intensity is directly propertional to the fluorescence lifetime.The effects of the interference of nineteen ions on the determination of uranium are measured, and it is found that most of the ions have no interference. However, Fe, Pb, Mn interfere moderately, whereas Ag interferes strongly.
Robust Control in Power Systems (2005)

algebraic variables C.2 Static VAr compensator (SVC) C.2.1 W.r.t state variables C.2.2 W.r.t algebraic variables C.3 Thyristor controlled phase angle regulator (TCPAR) C.3.1 W.r.t state variables C.3.2 W.r.t algebraic variables D Matlab Routine for Controller Design Using LMI Control Toolbox E Matlab Routine for Controller Design Using "hin f mix" Function Index
First‐in‐human implantation of a fully bioabsorbable drug‐eluting stent: The BVS poly‐L‐lactic acid everolimus‐eluting coronary stent (2006)

The first-in-human fully bioabsorbable drug-eluting stent (BVS poly-L-lactic acid everolimus-eluting coronary stent) implantation was performed at Auckland City Hospital, New Zealand as part of the ABSORB trial. There were no adverse events in-hospital or by 1 month. A stent that supports the vessel when needed, delivers an antiproliferative drug then disappears has theoretical advantages with regard to CT and MRI compatibility, restored vessel vasomotion, and facilitated future percutaneous intervention or surgical grafting to the treated site.
Hormonal stimulation for IVF treatment positively affects the CD56bright/CD56dim NK cell ratio of the endometrium during the window of implantation (2004)

The effects of hormone stimulation for IVF treatment on endometrial receptivity remain controversial. Since CD56(bright) natural killer (NK) cells in the endometrium positively contribute to implantation and decidualization whereas CD56(dim) NK cells are negatively associated with reproduction, shifts in the balance between those cells will affect receptivity. Therefore, we compared the leukocyte composition in the endometrium of IVF women (n=20) with non-pregnant women (n=18) in a natural cycle, as a parameter for endometrial quality. Biopsies were obtained 7 days after ovulation. Histological dating of the endometrium showed no increased endometrial advancement after IVF treatment as compared to the control group. Flow cytometric analysis of leukocyte subsets showed that hormonal stimulation positively affected the CD56(bright)/CD56(dim) ratio in the endometrium by a relative decrease in the cytotoxic CD56(dim)CD16(+) NK cell numbers. The relative number of T-cells remained unaffected, while the number of non-T and non-NK cells (i.e. B-cells and macrophages) was higher in the IVF group. These effects were restricted to the endometrium and not observed in peripheral blood. Within the CD56(bright) population we could identify a distinct subset of NK cells (CD56(superbright)) that was unique for the endometrium. We conclude that hormonal stimulation for IVF treatment positively affects the CD56(bright)/CD56(dim) ratio of the endometrium during the window of implantation and does not affect endometrial advancement.
Luxe et Luxure: Réflexions à partir de Sade (1998)

L'A. analyse l'epanouissement du libertinage en termes de luxe, quand, a partir de la fin du Siecle des Lumieres, le decor devient a son tour acteur et qu'il entretient avec le desir des relations complementaires. le luxe, defini comme la capacite d'erotiser les objets, devient ainsi partie prenante de l'ecriture erotique meme
Glucocorticoid receptors, in human alveolar macrophages and peripheral blood cells. (1982)

The numbers of glucocorticoid receptors in human alveolar macrophages and peripheral blood cells were measured with 3H-prednisolone. Alveolar macrophages, which constituted 89.0 +/- 5.9% of broncho-alveolar cells, obtained by broncho-alveolar lavage from normal volunteers had much larger numbers of specific glucocorticoid receptors than peripheral blood cells. The numbers of glucocorticoid receptors in peripheral polymorphonuclear leucocytes, lymphocytes and lymphocyte subpopulations (B cells, T cells, TG cells and TnonG cells) were nearly equal. In patients with idiopathic pulmonary fibrosis, in whom alveolar macrophages amounted to over 85% of the broncho-alveolar cells, the number of glucocorticoid receptors in alveolar macrophages was significantly decreased, but the numbers in their peripheral blood cells were normal. This finding suggests that the number of glucocorticoid receptors in alveolar macrophages may change specifically during disorders of the lung.
Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting Staphylococcus aureus Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers (2019)

ASN100 is a novel antibody combination of two fully human IgG1(κ) monoclonal antibodies (MAbs), ASN-1 and ASN-2, which neutralize six <i>Staphylococcus aureus</i> cytotoxins, alpha-hemolysin (Hla) and five bicomponent leukocidins. We assessed the safety, tolerability, and serum and lung pharmacokinetics of ASN100 in a randomized, double-blind, placebo-controlled single-dose-escalation first-in-human study. Fifty-two healthy volunteers were enrolled and randomized to receive either ASN-1, ASN-2, a combination of both MAbs (ASN100), or a corresponding placebo. Thirty-two subjects in the double-blind dose escalation portion of the study received ASN-1 or ASN-2 at a 200-, 600-, 1,800-, or 4,000-mg dose, or placebo. Eight subjects received both MAbs simultaneously in a 1:1 ratio (ASN100) at 3,600 or 8,000 mg, or they received placebos. Twelve additional subjects received open-label ASN100 at 3,600 or 8,000 mg to assess the pharmacokinetics of ASN-1 and ASN-2 in epithelial lining fluid (ELF) by bronchoalveolar lavage fluid sampling. Subjects were monitored for 98 days (double-blind cohorts) or 30 days (open-label cohorts) for safety assessment. No dose-limiting toxicities were observed, and all adverse events were mild and transient, with only two adverse events considered possibly related to the investigational product. ASN100 exhibited linear serum pharmacokinetics with a half-life of approximately 3 weeks and showed detectable penetration into the ELF. No treatment-emergent anti-drug antibody responses were detected. The toxin neutralizing potency of ASN100 in human serum was confirmed up to 58 days postdosing. The favorable safety profile, ELF penetration, and maintained functional activity in serum supported the further clinical development of ASN100.
Altered Fermentation Performances, Growth, and Metabolic Footprints Reveal Competition for Nutrients between Yeast Species Inoculated in Synthetic Grape Juice-Like Medium (2018)

The sequential inoculation of non-<i>Saccharomyces</i> yeasts and <i>Saccharomyces cerevisiae</i> in grape juice is becoming an increasingly popular practice to diversify wine styles and/or to obtain more complex wines with a peculiar microbial footprint. One of the main interactions is competition for nutrients, especially nitrogen sources, that directly impacts not only fermentation performance but also the production of aroma compounds. In order to better understand the interactions taking place between non-Saccharomyces yeasts and S. cerevisiae during alcoholic fermentation, sequential inoculations of three yeast species (<i>Pichia burtonii, Kluyveromyces marxianus, Zygoascus meyerae</i>) with <i>S. cerevisiae</i> were performed individually in a synthetic medium. Different species-dependent interactions were evidenced. Indeed, the three sequential inoculations resulted in three different behaviors in terms of growth. <i>P. burtonii</i> and <i>Z. meyerae</i> declined after the inoculation of <i>S. cerevisiae</i> which promptly outcompeted the other two species. However, while the presence of <i>P. burtonii</i> did not impact the fermentation kinetics of <i>S. cerevisiae</i>, that of <i>Z. meyerae</i> rendered the overall kinetics very slow and with no clear exponential phase. <i>K. marxianus</i> and <i>S. cerevisiae</i> both declined and became undetectable before fermentation completion. The results also demonstrated that yeasts differed in their preference for nitrogen sources. Unlike <i>Z. meyerae</i> and <i>P. burtonii, K. marxianus</i> appeared to be a competitor for <i>S. cerevisiae</i> (as evidenced by the uptake of ammonium and amino acids), thereby explaining the resulting stuck fermentation. Nevertheless, the results suggested that competition for other nutrients (probably vitamins) occurred during the sequential inoculation of <i>Z. meyerae</i> with <i>S. cerevisiae</i>. The metabolic footprint of the non-<i>Saccharomyces</i> yeasts determined after 48 h of fermentation remained until the end of fermentation and combined with that of <i>S. cerevisiae</i>. For instance, fermentations performed with <i>K. marxianus</i> were characterized by the formation of phenylethanol and phenylethyl acetate, while those performed with <i>P. burtonii</i> or <i>Z. meyerae</i> displayed higher production of isoamyl alcohol and ethyl esters. When considering sequential inoculation of yeasts, the nutritional requirements of the yeasts used should be carefully considered and adjusted accordingly. Finally, our chemical data suggests that the organoleptic properties of the wine are altered in a species specific manner.
Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients (2015)

MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n=10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation <3 °C). No unwanted heating in the near field (i.e. skin) nor in the far field (pectoral muscle) was detected.The newly developed dedicated breast MR-HIFU system allows for safe, accurate and precise ablation of breast tumors.
Existence of a Free Form of a Specific Membrane Lipoprotein in Gram-Negative Bacteria (1974)

The existence of a free form of a specific lipoprotein of molecular weight 7,200 was examined in the envelopes of several gram-negative bacteria. When the envelope proteins were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis, distinct peaks were observed in Salmonella typhimurium, Serratia marcescens, and Pseudomonas aeruginosa at the same position as the free form of the lipoprotein of Escherichia coli. However, the peak was not observed in Proteus mirabilis. The protein at the peak in S. typhimurium was shown to contain little or no histidine as expected from the amino acid composition of the lipoprotein. Furthermore, antiserum against the highly purified lipoprotein from E. coli was shown to react with the proteins from S. typhimurium and S. marcescens and to form the specific immunoprecipitates. In contrast, the protein from P. aeruginosa did not react with the antiserum at all. Thus, it is concluded that S. typhimurium and S. marcescens have the free form of the lipoprotein in their envelopes as does E. coli. P. aeruginosa contains a protein of the same size as the lipoprotein, but it is not certain whether the protein is the same structural protein as the lipoprotein from E. coli. P. mirabilis may not have any free form of the lipoprotein, may have it in a very small amount, or may have a lipoprotein of different molecular weight serving the same function.
Several Key Issues on Implementing Delay Line Based TDCs Using FPGAs (2010)

This paper discusses implementation of the Wave Union TDC, a novel scheme of FPGA TDC to improve time measurement precision using multiple measurements, along with several other topics in FPGA delay line based TDCs. FPGA specific issues such as considerations on the delay line choice in different FPGA families and encoding logic are first examined. Next, common problems for both FPGA TDCs and ASIC TDCs such as schemes of coarse time counter implementation, bin-by-bin calibration and noise issues due to single ended signals are discussed. Several resource/power saving design approaches for various processing stages are described in the document.
Effect of Gastric Bypass Operation on Framingham and Actual Risk of Cardiovascular Events in Class II to III Obesity (2007)

Gastric bypass operation is effective in reducing actual and the 10-year Framingham risk of CHD events in individuals with class II to III obesity. The major estimated risk reduction was observed in male patients with type 2 diabetes.
Three-dimensional stacking miniaturization and high frequency of resonant ring (2019)

When the electronic products are going to high-frequency and high-speed, electromagnetic interference is caused by the coupling between the lines. Controlled electromagnetic coupling is becoming an important basis for designing lines; in addition to the coupling mechanism, the development of miniaturization of electronic products, using Z-axis superposition to couple to reduce the circuit area, is also an important design basis on the system circuit. This paper is to analyze the coupling feeding mechanism of the resonant ring and the coupling mechanism between the resonant rings, and introduce the near-field radiation field type verification technology. The three-dimensional stacking of the circuit is achieved by redesigning the coupling mechanism. Miniaturization and high frequency are the main purposes of this study.
Prepation and Stability of Aqueous-Based Enteric Polymer Dispersions (1986)

Aqueous, colloidal dispersions of the enteric polymers, cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HP-551, and polyvinyl acetate phthalate (PVAP) have been developed; and their application in tablet film coating demonstrated. The formation of free phthalic acid as a result of phthalate ester hydrolysis was monitored during storage of the dispersions. Increased free phthalic acid concentrations were found to adversely affect physical stability in dispersions of the cellulose polymers. Storage temperature and pH effects on phthalate ester stability were also considered