gebhart/patrepeval huggingface dataset:
Laparoscopic management of pudendal pain different endopelvic etiologies in 134 consecutive patients (2007)

Objective: To demonstrate the feasability of the laparoscopic transperitoneal approach to the pelvic somatetic 10 nerves for the diagnosis and treatment of ano-genital pain caused by pudendal and/or sacral nerve roots lesions. Method: In a retrospective review, 134 consecutive patients underwent laparoscopy for refractory ano-genital pain. All neurosurgical procedures such as neurolysis/decompression of the pudendal nerve and of the sacral nerve roots or implantation of neuroelectrode to the sacral plexus for postoperative neuromodulation were done by laparoscopic transperitoneal approach of the pelvic nerves. 15 Results: Eighteen patients had Alcock s canal syndrome and decompression was successful in 15. The three patients because of failure of the decompression underwent secondarly a sacral LION procedure with reduction at least 50% in pain VAS in all three. Sacral plexus lesions – radiculopathies -, most commonly post-surgical lesions and retroperitoneal endometriosis were found in 109 patients. All of these underwent a laparoscopic neurolysis of the sacral plexus; the final outcome depended on the etiology: For patients with post-surgical nerve 20 damage, 62% had a reduction of the mean preoperative VAS from 8,9 (±2,9, 7-10 ) to 2,4 (±2,3, 0-4) at time of submission this manuscript with a mean follow-up of 17 months (339 months). Eight of them underwent secondarly because of failure of decompression, a sacral LION procedure: A pain VAS reduction was obtained in five of them. For endometriosis lesion of the sacral plexus, 78% had a reduction of the mean preoperative VAS score of 8,7 (±1,9; 8-10) to 1,1 (±0,7, 0-2) at time of submission the manuscript (mean follow-up 21 months, 225 42 months). For vascular entrapment of pelvic nerves (n=6), all patients had complete relief. The last seven patients underwent primarly a sacral LION procedure with a pain VAS reduction at least 50% in four of them.
Raman spectroscopic study of the synthesis of zeolite Y (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectroscopic study of the synthesis of zeolite YPrabir K. Dutta, D. C. Shieh, and M. PuriCite this: J. Phys. Chem. 1987, 91, 9, 2332–2336Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/j100293a025https://doi.org/10.1021/j100293a025research-articleACS PublicationsRequest reuse permissionsArticle Views1221Altmetric-Citations146LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synthesis of 1,2-Dithiolane Analogues of Leucine for Potential Use in Peptide Chemistry (2002)

[reaction: see text]1,2-Dithiolanes present several points of interest for both peptide and medicinal chemistry, yet no chiral alpha-amino acids containing this five-membered heterocyclic system are available. We report here the first synthesis of N- and C-protected derivative of (S)-2-amino-3-(1,2-dithiolan-4-yl)propionic acid (Adp) and its 1,3-dithiolic form.
Relation between the quantity of adsorbed cadmium ions and the zeta potentials on the surface of cadmium sulfide powders (1977)

硫化カドミウムを主成分とするカドミウムイオン選択性電極の電位発生機構を知るための一つの手段として,硫化カドミウム粉末表面上へのカドミウムイオンの吸着量とすべり面とカドミウムイオン溶液相との間の内部電位差であるゼータ電位との関係を求めた.10-6M～10-2Mのカドミウムイオン濃度に対して,焼結体が十分なネルンスト応答を示す1%の硫化銀を含む硫化カドミウム粉末と,焼結体が十分なネルンスト応答を示さない硫化カドミウム粉末及び5%の硫化インジウムを含む硫化カドミウム粉末とについて,カドミウムイオンの吸着量には大きな差が認められなかった.又,カドミウムイオンの濃度変化に対する1%の硫化銀を含む硫化カドミウム粉末のゼータ電位の変化が,ネルンスト応答と比較して小さいことから,カドミウムイオンの濃度変化に対する硫化カドミウム相とカドミウムイオン溶液相との間の内部電位差の変化は主としてすべり面と硫化カドミウム内部との間で起こると推定した.
ToxR-Independent Expression of Cholera Toxin from the Replicative Form of CTXφ (1998)

The ctxAB operon, which encodes cholera toxin, resides in the genome of CTXphi, a filamentous bacteriophage. Within Vibrio cholerae cells, the CTXphi genome can exist either as a replicating plasmid or as a prophage integrated into the chromosome. Previous work established that ToxR is required for chromosomal ctxAB expression. We have learned that strains harboring the CTXphi replicative form produce cholera toxin under all conditions tested, independently of ToxR. During passage of CTXphi lysogens through the infant mouse intestine, transduction of CTXphi to a recipient strain can be detected, indicating that phage excision and replication occur in vivo. These results suggest that phage induction might provide a novel mechanism for the regulation of cholera toxin production.
Performance evaluation of Virtual Machine (VM) scheduling policies in Cloud computing (spaceshared &amp; timeshared) (2013)

The concept Cloud computing has not only reshaped the field of distributed systems but also fundamentally changed how business potential extends today. In recent advancements, Cloud computing applications are provided as services to end-users. The application services hosted under Cloud computing model have complex provisioning, configuration, and deployment requirements How to use Cloud computing resources efficiently and gain the maximum profits with efficient utilization of resources is one of the Cloud computing service providers' ultimate goals. Repetitive evaluation of the performance of Cloud provisioning policies, application workload models, and resources performance models in dynamic system are difficult to achieve and rather a time consuming and costly approach. To overcome this challenge, Cloud analyst simulator based on Cloud Sim has been proposed which enables the modeling and simulation in cloud's ambience. The objective of this paper is to prove that the choice of VM Scheduling Policy in Cloud computing model significantly improves the application performance under resource and service demand variations. We will discuss different Virtual Machine (VM) Scheduling Policies implemented and their performance analysis in Virtual environment of cloud computing in order to achieve better Quality of Service (QoS).
Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade. (1994)

Expression of adhesins, toxins, and other virulence factors of Bordetella pertussis is under control of the BvgA and BvgS proteins, members of a bacterial two-component signal transduction family. BvgA bears sequence similarity to regulator components, whereas BvgS shows similarity to both sensor and regulator components. BvgA and the cytoplasmic portion of BvgS ('BvgS) were overexpressed and purified. 'BvgS autophosphorylated with the gamma-phosphate from [gamma-32P]ATP and phosphorylated BvgA. Kinetic analysis indicated that BvgA receives its phosphate from 'BvgS. Mutations in the transmitter, receiver, and C-terminal domains of BvgS were tested for activation of a BvgAS-dependent fhaB::lacZ reporter fusion in vivo and for autophosphorylation and phosphotransfer to BvgA in vitro. All mutations abolished activation of the fhaB::lacZ fusion. A point mutation in the transmitter (H729Q) prevented autophosphorylation of 'BvgS. In contrast to other characterized sensor proteins, autophosphorylation also required sequences in the 'BvgS receiver and C-terminal domains. A 'BvgS receiver point mutation (D1023N) had the novel phenotype of being able to autophosphorylate but unable to transfer the phosphate to BvgA. Autophosphorylation activity of the D1023N mutant protein was kinetically and chemically indistinguishable from wild-type 'BvgS despite an uncoupling of phosphotransfer from autophosphorylation. 'BvgS was shown to contain primarily amidyl phosphate and BvgA an acyl phosphate linkage. We present a model for a phosphorelay controlling virulence gene expression in B. pertussis.
Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits (2018)

Hypertrophic cardiomyopathy (HCM) is a primary disorder of contractility in heart muscle. To gain mechanistic insight and guide pharmacological rescue, this study models HCM using isogenic pairs of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) carrying the E99K-ACTC1 cardiac actin mutation. In both 3D engineered heart tissues and 2D monolayers, arrhythmogenesis was evident in all E99K-ACTC1 hiPSC-CMs. Aberrant phenotypes were most common in hiPSC-CMs produced from the heterozygote father. Unexpectedly, pathological phenotypes were less evident in E99K-expressing hiPSC-CMs from the two sons. Mechanistic insight from Ca<sup>2+</sup> handling expression studies prompted pharmacological rescue experiments, wherein dual dantroline/ranolazine treatment was most effective. Our data are consistent with E99K mutant protein being a central cause of HCM but the three-way interaction between the primary genetic lesion, background (epi)genetics, and donor patient age may influence the pathogenic phenotype. This illustrates the value of isogenic hiPSC-CMs in genotype-phenotype correlations.
Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system (2009)

As an inhabitant of the human oral cavity, Streptococcus mutans faces frequent environmental changes. Two-component regulatory systems (TCSs) play a critical role in responding to these changes. Recently, an essential TCS, VicRKX, has been identified. The objective of this study was to identify the environmental signal and bacterial factors regulating the expression of the vicRKX operon. The promoter of the vicRKX operon was fused to a promoterless lacZ reporter gene and introduced into S. mutans UA159. LacZ plate assay identified pH, vancomycin, ampicillin, penicillin G and polymyxin B, but not carbohydrates, as factors affecting expression. Using RNA dot-blotting, high levels of vicR transcript were observed in cells at the mid- and late-exponential phase of growth and in cells grown in media buffered at pH 7.8. Given that vicR expression was pH-dependent, the genes encoding a putative pH-sensing three-component regulatory system (LiaFSR) were deleted. The liaS mutant exhibited upregulation of vicR regardless of the growth condition. The role of VicK, VicX, and the competence-signal peptide (CSP) was also investigated; the results showed that vicR expression was not autoregulated and was downregulated by the CSP in a ComX-independent manner. In conclusion, the expression of vicRKX is influenced by culture pH, growth phase and antibiotic stress, and is regulated by LiaFRS.
Systematic mutation analysis of KIAA0767 and KIAA1646 in chromosome 22q-linked periodic catatonia (2005)

Starting from linkage signals at chromosome22qtel in periodic catatonia, we screened two positional brain-expressed candidate genes for genetic variation. Our study excludes genetic variations in the coding and putative promoter regions of KIAA0767 and KIAA1646 as causative factors for periodic catatonia.
Resonant coupling in dielectric loaded plasmonic waveguides (2010)

Light propagation in dielectric loaded surface plasmon polariton waveguide (DLSPPW) resonant coupling devices operating at visible frequencies was experimentally investigated. The transmission characteristics of these devices were studied by leakage radiation microscopy. We show that a strong coupling between DLSPPWs can be achieved with nanoscale gaps. We demonstrate the operation of compact DLSPPW linear couplers and 3 dB power splitters. The performances of micro-DLSPPW racetrack resonators and signal drop filter are also discussed.
Control of a team of micro-robots for non-invasive medical applications (2011)

International audience
Fractional rate multitree speech coding (1991)

The authors present both forward and backward adaptive speech coders that operate at 9.6, 12, and 16 kb/s using integer and fractional rate trees, weighted squared error distortion measures, the (M,L) tree search algorithm, and incremental path map symbol release. They introduce the concept of multitree source codes and illustrate how the multitree structure allows scalar quantizer-based codes and scalar adaptation rules to be used for fractional rate tree coding. With a frequency weighted distortion measure, the forward and backward adaptive multitree coders produce near toll quality speech at 16 kb/s, while the backward adaptive 9.6 kb/s multitree coder substantially outperforms adaptive predictive coding and has an encoding delay of less than 2 ms. Performance results are present in terms of unweighted and weighted signal-to-noise ratio and segmental signal-to-noise ratio, sound spectrograms, and subjective listening tests.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Induction of rat hepatic cytochromes P450 by toxic ingredients in plants: Lack of correlation between toxicity and inductive activity. (1998)

"Animal-Plant Warfare" is one of the hypotheses for the evolution of drug-metabolizing P450s. To address the validity of this hypothesis, we examined the induction of xenobiotic-metabolizing P450s by 12 plant toxins in rats, using hepatic activity for testosterone metabolism as the index. The compounds tested were aconitine, morphine, tubocurarine, physostigmine, pilocarpine, muscarine, cocaine, atropine, amygdalin, digitonin, nicotine and solanine. Drinking water containing a test compound was given to rats for 4 days, and the hepatic activity of testosterone metabolism was determined together with monitoring body weight gain and liver weight as the indices of toxicity. The results showed that while cocaine and nicotine have a minor ability to increase testosterone 16 beta-hydroxylase activity, a marker activity for the CYP2B1 and 2, all other compounds did not have any such effect. No correlation was observed between a change in 16 beta-hydroxylase and toxicity caused by toxins. Therefore, these results did not support the idea that the inducibility of the CYP2B subfamily in animals is acquired through "Animal-Plant Warfare". Several compounds examined here increased or decreased hepatic activities of testosterone 2 alpha-, 6 beta-, 7 alpha- and 16 alpha-hydroxylation and 17-oxidation, indicating a possible effect on the CYP2A, 2C and 3A subfamily. Of these effects, a moderate correlation (r < 0.49) was observed in the changes in the activities of 2 alpha-/16 alpha-hydroxylation and 17-oxidation vs. that in toxicity. It is therefore suggested that inhibition or suppression of the expression of CYP2C11 is one of the mechanisms in the toxicity of plant toxins for rats, although it comes from an examination using limited numbers of compounds.
Association between aflatoxin-albumin adduct levels and tortilla consumption in Guatemalan adults (2019)

Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is a known human hepatocarcinogen and a recent study reported elevated AFB<sub>1</sub> levels, measured by serum albumin biomarkers, among Guatemalan adults. While AFB<sub>1</sub> can contaminate a variety of foodstuffs, including maize, Guatemala's main dietary staple, the relationship of maize intake to serum AFB<sub>1</sub>-albumin adducts levels in Guatemala has not been previously examined. As a result, a cross-sectional study was conducted among 461 Guatemalan adults living in five geographically distinct departments of the country. Participants provided a serum sample and completed a semi-quantitative food frequency questionnaire and a sociodemographic questionnaire. Multiple linear regression analysis was used to estimate the least square means (LSQ) and 95% confidence intervals (95% CI) of log-transformed AFB<sub>1</sub>-albumin adducts by quintiles of maize consumption in crude and adjusted models. Additionally, analyses of tortilla consumption and levels of maize processing were conducted. The median maize intake was 344.3 g per day [Interquartile Range (IQR): 252.2, 500.8], and the median serum AFB<sub>1</sub>-albumin adduct level was 8.4 pg/mg albumin (IQR: 3.8, 22.3). In adjusted analyses, there was no association between overall maize consumption and serum AFB<sub>1</sub>-albumin levels. However, there was a statistically significant association between tortilla consumption and AFB<sub>1</sub>-albumin levels (p<sub>trend</sub> = 0.01). The LSM of AFB<sub>1</sub>-albumin was higher in the highest quintile of tortilla consumption compared to the lowest quintile [LSM:9.03 95%CI: 7.03,11.70 vs 6.23, 95%CI: 4.95,8.17, respectively]. These findings indicate that tortilla may be an important source of AFB<sub>1</sub> exposure in the Guatemalan population. Therefore, efforts to control or mitigate AFB<sub>1</sub> levels in contaminated maize used for tortillas may reduce overall exposure in this population.
A new procedure for efficient recovery of DNA, RNA, and proteins from Listeria cells by rapid lysis with a recombinant bacteriophage endolysin (1995)

A method for the rapid lysis of Listeria cells, employing a recombinant Listeria bacteriophage A118 lytic enzyme (PLY118), is described. The procedure can be used with all listerial species. It enables fast, efficient, and gentle recovery of DNA, RNA, or native cellular proteins from small-scale (2- to 5-ml) cultures. Moreover, this approach should be very useful in analytical detection and differentiation of Listeria strains when the release of native nucleic acids or proteins is required.
Asymmetric Synthesis of Aziridines by Reduction of N-tert-Butanesulfinyl α-Chloro Imines (2007)

Reduction of (RS)-N-tert-butanesulfinyl alpha-halo imines afforded chiral aziridines in good to excellent yields. Upon reduction of (RS)-N-tert-butanesulfinyl alpha-halo imines with NaBH4 in THF, in the presence of 10 equiv of MeOH, (RS,S)-beta-halo sulfinamides were formed in excellent yield (up to 98%) with very good stereoselectivity (>98:2). Simple treatment of the latter (RS,S)-beta-halo-tert-butanesulfinamides with KOH afforded the corresponding (RS,S)-N-(tert-butylsulfinyl)aziridines in quantitative yields. On the contrary, its epimer, (RS,R)-N-(tert-butylsulfinyl)aziridine was synthesized by switchover of the reducing agent from NaBH4 to LiBHEt3. (RS,R)-N-(tert-Butylsulfinyl)aziridines were synthesized in good yields (up to 85%) and diastereoselectivity (up to 92:8) by reduction of (RS)-N-tert-butanesulfinyl alpha-halo imines with LiBHEt3 in dry THF and subsequent treatment with KOH. All chiral aziridines were obtained as a single diastereomer after recrystallization (overall yield up to 91%) or after flash chromatography.
High electron density ${\beta}-(Al_{0.18}Ga_{0.82})_2O_3/Ga_2O_3$ modulation doping using ultra-thin (1 nm) spacer layer (2019)

We report on the design and demonstration of ${\beta}-(Al_{0.18}Ga_{0.82})_2O_3/Ga_2O_3$ modulation doped heterostructures to achieve high sheet charge density. The use of a thin spacer layer between the Si delta-doping and heterojunction interface was investigated in ${\beta}-(Al_{0.18}Ga_{0.82})_2O_3/Ga_2O_3$ modulation doped structures. We find that that this strategy enables higher 2DEG sheet charge density up to 6.1x10^12 cm^2 with mobility of 147 cm^2/Vs. The presence of a degenerate 2DEG channel was confirmed by the measurement of low temperature effective mobility of 378 cm^2/V-s and a lack of carrier freeze out from low temperature capacitance voltage measurements. The electron density of 6.1x10^12 cm^2 is the highest reported sheet charge density obtained without parallel conduction channels in an $(Al_{0.18}Ga_{0.82})_2O_3/Ga_2O_3$ heterostructure system.
Sulla illegittima formulazione del quesito referendario di approvazione della riforma Renzi-Boschi (2016)

SOMMARIO: 1. Un diritto costituzionale privo di tutela giurisdizionale? - 2. La legge di revisione della Costituzione non è una qualunque altra legge costituzionale. - 3. Sulla competenza a formulare il quesito referendario. - 4. Sul “titolo” del disegno di legge costituzionale in pendenza della procedura referendaria.
A case of systemic lupus erythematosus with five episodes of herpes zoster (1983)

A 18-year old female developed polyarthralgia and Raynaud's phenomenon in 1973. She was admitted to the hospital because of recurrent fever in 1976, and diagnosed as having SLE, manifested by facial butterfly rash, nonerosive arthritis, proteinuria, leukopenia, positive LE cell preparation, abnormal titer of antinuclear antibody and anti-DNA antibody.The patient had episodes of herpes zoster at 4, 28, 38, 52 and 59 months after initial symptoms of SLE. The course of herpes zoster was favorable and all episodes resolved without complications.She had deficiency in cell-mediated immunity, such as skin tests with PPD, DNCB, and IgG Fc receptor positive T cells. But the abnormalities were found both with and without herpes zoster infection. Decrease of complement titer was observed whenever herpes zoster occurred.She first suffered from herpes zoster prior to the initiation of steroid theroid therapy, and received prednisolone at doses from 12.5mg to 30mg daily on 4 episodes of herpes zoster.It seemed that one of the causes on the multiple zoster infections, which were observed in early time after the onset of SLE, was low level of serum complement.
A Kinetic Study of the Reactions of Amino Acids and Peptides with Trinitrobenzenesulfonic Acid* (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Kinetic Study of the Reactions of Amino Acids and Peptides with Trinitrobenzenesulfonic Acid*A. R. GoldfarbCite this: Biochemistry 1966, 5, 8, 2570–2574Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/bi00872a013https://doi.org/10.1021/bi00872a013research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimental validation of a multiple wavelength Photo-Magnetic Imaging system (2020)

Photo-Magnetic Imaging (PMI) is a novel multimodality imaging technique that provides optical absorption maps with high-resolution and quantitative accuracy. Here, we present the preliminary experimental validation results obtained using our new multi-wavelength PMI system.