gebhart/patrepeval huggingface dataset:
Electrical properties of Er-doped BaTiO/sub 3/ ceramics for PTCR applications (2003)

The electrical properties of Er-doped BaTiO/sub 3/ ceramics with different amounts of dopant in the range (0.25-8) at.% and with electron compensation were studied using D.C.-resistance and impedance spectroscopy (IS) measurements. The experimental results were compared with the Double Barrier Schottky theory for the description of the PTCR effect. D.C. resistance results and microstructure analyses were used to discuss the role of dopant concentration, mechanism of incorporation and cooling rate on the PTCR behaviour. Optimum processing parameters that ensure the best PTCR ratio were found. IS measurements were performed at various temperature over the whole transition range and grain boundary and bulk contributions were extracted by a non linear least squares fitting procedure. Dielectric constant and resistivity values were obtained and used to derive model parameters for different samples. Temperature dependence of total resistivity was calculated and compared to D.C. curves. The agreement is good in a large range of temperature, including the ferro-para phase transition.
IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice (2007)

UV radiation-induced immunosuppression contributes significantly to the development of UV-induced skin cancer by inhibiting protective immune responses. IL-10 has been shown to be a key mediator of UV-induced immunosuppression. To investigate the role of IL-10 during photocarcinogenesis, groups of IL-10(+/+), IL-10(+/-), and IL-10(-/-) mice were chronically irradiated with UV. IL-10(+/+) and IL-10(+/-) mice developed skin cancer to similar extents, whereas IL-10(-/-) mice were protected against the induction of skin malignancies by UV. Because UV is able to induce regulatory T cells, which play a role in the suppression of protective immunity, UV-induced regulatory T cell function was analyzed. Splenic regulatory T cells from UV-irradiated IL-10(-/-) mice were unable to confer immunosuppression upon transfer into naive recipients. UV-induced CD4+CD25+ T cells from IL-10(-/-) mice showed impaired suppressor function when cocultured with conventional CD4+CD25- T cells. CD4+CD25- T cells from IL-10(-/-) mice produced increased amounts of IFN-gamma and enhanced numbers of CD4+TIM-3+ T cells were detectable within UV-induced tumors in IL-10(-/-) mice, suggesting strong Th1-driven immunity. Mice treated with CD8+ T cells from UV-irradiated IL-10(-/-) mice rejected a UV tumor challenge significantly faster, and augmented numbers of granzyme A+ cells were detected within injected UV tumors in IL-10(-/-) animals, suggesting marked antitumoral CTL responses. Together, these findings indicate that IL-10 is critically involved in antitumoral immunity during photocarcinogenesis. Moreover, these results point out the crucial role of Th1 responses and UV-induced regulatory T cell function in the protection against UV-induced tumor development.
Reliability of densitometry for the assessment of the immediate results after implant of radiolucent coronary artery stents (2002)

Coronary artery stents have emerged as the most promising device for coronary interventions. The outcome of coronary stenting depends on postprocedural lumen diameter. The aim of the study was to compare two angiographic methods for the quantitation of minimal luminal diameter (MLD) before and after implant of 126 coronary stents. Before angioplasty, the MLD measured by the two techniques correlated (r=0.706) and the mean difference was -0.47/spl plusmn/0.43 mm). After stent implant, the correlation coefficient increased to 0.782 and the mean difference decreases to -0.21/spl plusmn/0.50 mm. Thus both methods are appropriate to measure MLD in coronary segments, but the correlation is higher when the vascular conduit is remodelled by an endovascular prosthesis.
LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea (2022)

CRISPR/Cas9-based genome-editing therapies are poised to change the clinical outcome for many diseases with validated therapeutic targets awaiting an appropriate delivery system. Recent advances in lipid nanoparticle (LNP) technology make them an attractive platform for the delivery of various forms of CRISPR/Cas9, including the efficient and transient Cas9/gRNA ribonucleoprotein (RNP) complexes. In this study, we initially tested our novel LNP platform by delivering pre-complexed RNPs and template DNA to cultured mouse cortical neurons, and obtained successful ex vivo genome editing. We then directly injected LNP-packaged RNPs and DNA template into the mouse cornea to evaluate in vivo delivery. For the first time, we demonstrated wide-spread genome editing in the cornea using our LNP-RNPs. The ability of our LNPs to transfect the cornea highlights the potential of our novel delivery platform to be used in CRISPR/Cas9-based genome editing therapies of corneal diseases.
Type systems for object-oriented intermediate languages (2000)

In the standard Java implementation, a Java language program is compiled to bytecode. This bytecode may be sent across the network to another site, where it is then executed by the Java Virtual Machine. Since bytecode may be written by hand, or corrupted during network transmission, the Java Virtual Machine contains a bytecode verifier that performs a number of consistency checks before code is run. These checks include type correctness, and, as illustrated by previous attacks on the Java Virtual Machine, they are critical for system security. However, there is no existing specification which fully captures how Java bytecodes must be type checked. 
In order to analyze verification of such a language and to understand the properties that should be checked to preserve system security, we develop a precise specification of statically-correct Java bytecode, in the form of a type system. We study a subset of the bytecode language including classes, interfaces, constructors, methods, exceptions, and byte-code subroutines. We also describe a prototype implementation of a type checker for our system and discuss some applications of this work. For example, we show how to extend our formal system to check other program properties, such as the correct use of object locks. 
This work has helped to clarify the original bytecode verifier specification, uncovered a security flaw in the Sun verifier implementation, and points to ways in which the bytecode language may be simplified and extended.
Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research (2021)

Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent investigations have increasingly focused on understanding human islet biology. Studies of isolated human islets have advanced understanding of the development, function, and regulation of cells comprising islets, especially pancreatic α- and β-cells. However, the multicellularity of the intact islet has stymied specific experimental approaches—particularly in genetics and cell signaling interrogation. This barrier has been circumvented by the observation that islet cells can survive dispersion and reaggregate to form ‘pseudoislets’, organoids that retain crucial physiological functions, including regulated insulin and glucagon secretion. Recently, exciting advances in the use of pseudoislets for genetics, genomics, islet cell transplantation, and studies of intra-islet signaling and islet cell interactions have been reported by investigators worldwide. Here we review molecular and cellular mechanisms thought to promote islet cell reaggregation, summarize methods that optimize pseudoislet development, and detail recent insights about human islet biology from genetic and transplantation-based pseudoislet experiments. Owing to robust, international programs for procuring primary human pancreata, pseudoislets should serve as both a durable paradigm for primary organoid studies and as an engine of discovery for islet biology, diabetes, and metabolism research.
Analysis of ESP Instructing and Innovation of College English Teaching (2015)

In contemporary society, with comprehensive promotion of global economy, there is an urgent need for well-rounded talents in a wide variety of professional fields, which undoubtedly set a higher goal for the broadly-based education. The innovation of English teaching in higher education plays a significant and active function in the process of cultivating all-rounded talents. At present, EPS instruction has been penetrating into the innovation of English teaching education actively.
HERITABILITY OF MYOPIA AS A FUNCTION OF AGE AND FAMILY RELATIONSHIP. (2002)

Friday, December 13, 2002: San Diego Convention Center: Room 11 B: Optics and Refraction Lectures: PDF Only
The CompleteSearch Engine: Interactive, Efficient, and Towards IR & DB integration (2007)

We describe CompleteSearch, an interactive search engine that offers the user a variety of complex features, which at first glance have little in common, yet are all provided via one and the same highly optimized core mechanism. This mechanism answers queries for what we call context-sensitive prefix search and completion: given a set of documents and a word range, compute all words from that range which are contained in one of the given documents, as well as those of the given documents which contain a word from the given range. Among the supported features are: (i) automatic query completion, for example, find all completions of the prefix “seman” that occur in the context of the word “ontology”, as well as the best hits for any such completion; (ii) semi-structured (XML) retrieval, for example, find all emailmessages with “dbworld” in the subject line; (iii) semantic search, for example, find all politicians which had a private audience with the pope; (iv) DB-style joins and grouping, for example, find the most prolific authors with at least one paper in both “SIGMOD” and “SIGIR”; and (v) arbitrary combinations of these. The prefix search and completion mechanism of Complete- Search is realized via a novel kind of index data structure, which enables subsecond query processing times for collections up to a terabyte of data, on a single PC. We report on a number of lessons learned in the process of building the system and on our experience with a number of publicly used deployments.
Different Pharmacological Interaction of Clonidine and Guanabenz with Antidepressive Drugs (1987)

A study was made of the effect of several antidepressive drugs with different mechanisms of action on cardiovascular response induced by clonidine (CLO) or guanabenz (GUA) in anaesthetized normotensive rats. The acute pretreatment (1 mg.kg-1) with desipramine (DMI), maprotiline (MAP) and mianserin (MIA) reduced the hypotensive and bradycardiac responses induced by CLO (10 micrograms.kg-1), while only MIA prevented these central actions when elicited by GUA (30 micrograms.kg-1). Only chronic treatment with DMI reduced the hypotensive effect of CLO, but none of long-term antidepressant administrations decreased the fall in blood pressure induced by GUA. The long-term administration of DMI, MAP and MIA abolished the bradycardia from both agonists, CLO and GUA. The different pharmacological interaction of CLO and GUA with (acute or chronic) antidepressive treatments could be explained by a structural difference between the two agonists, and also by differences in localization and/or subtype of the alpha-adrenoceptors involved in their central cardiovascular effects.
Engineering the iron‐oxidizing chemolithoautotroph Acidithiobacillus ferrooxidans for biochemical production (2015)

There is growing interest in developing non-photosynthetic routes for the conversion of CO2 to fuels and chemicals. One underexplored approach is the transfer of energy to the metabolism of genetically modified chemolithoautotrophic bacteria. Acidithiobacillus ferrooxidans is an obligate chemolithoautotroph that derives its metabolic energy from the oxidation of iron or sulfur at low pH. Two heterologous biosynthetic pathways have been expressed in A. ferrooxidans to produce either isobutyric acid or heptadecane from CO2 and the oxidation of Fe(2+). A sevenfold improvement in productivity of isobutyric acid was obtained through improved media formulations in batch cultures. Steady-state efficiencies were lower in continuous cultures, likely due to ferric inhibition. If coupled to solar panels, the photon-to-fuel efficiency of this proof-of-principle process approaches estimates for agriculture-derived biofuels. These efforts lay the foundation for the utilization of this organism in the exploitation of electrical energy for biochemical synthesis.
A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore®-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial” (2020)

The study is registered in clinicaltrials.gov on 29th April 2020 with the identification number: NCT04368156 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
Video-based avatar reconstruction and motion capture (2005)

This dissertation introduces a unified data acquisition, processing and synthesis framework for the creation of biomechanically correct human avatars. Contributions include a methodology for the creation of geometric skeletons from video streams, techniques to improve the video capture conditions, and a mathematical model for the treatment of human skeletal motion. 
Assuming a 3D environment populated with humans and a network of vision-based sensors monitoring it, the image data can be used to synthesize avatars. Specifics of the acquisition system, such as environment, capture volume, time, budget, required accuracy and desired processing speed are discussed. In this context, techniques for the selection of camera characteristics, camera placement and calibration are introduced. Subsequently, synthetically generated datasets are compared against real data, to validate that engineering precision demands can be satisfied. 
Given multiple video streams, a sequence of volumes is computed, and based on their spatiotemporal analysis, a sequence of geometric skeletons approximating the captured subject is extracted. A geometric skeleton describes an object as a combination of geometric entities, together with topological information such as connectivity and extreme locations. In case the geometric skeleton is part of a sequence, temporal consistency is ensured. Furthermore, using a dimensional kinematic synthesis approach, articulated motion is recovered as a kinematic skeleton and a set of parameters describing its inverse kinematics. The kinematic skeleton compactly characterizes the motion of the avatar, allowing for its subsequent animation. The mathematical formulation is based on dual quaternions, supporting the synthesis of R-, S- and T-joints. The initial motion sequence is expressed as a collection of geometric skeletons, for which the coordinate frames corresponding to each limb are consistently aligned over time. 
To validate the proposed kinematic synthesis methodology, a quantitative and qualitative analysis was conducted for a number of case studies, based on synthetic and real motion capture data. Algorithm accuracy and execution times are discussed and analyzed in detail, demonstrating the effectiveness of the approach for human motion recovery at interactive rates.
Supplementary Table 1, Figures 1 - 8 from PLA2R1 Mediates Tumor Suppression by Activating JAK2 (2023)

&lt;p&gt;PDF file - 326K, Supplementary Figure 1: The knockdown of PLA2R1 favors OIS escape. Supplementary Figure 2: The knockdown of PLA2R1 favors transformation. Supplementary Figure 3: The knockdown of PLA2R1 favors OIS escape in human normal keratinocytes. Supplementary Figure 4: DMBA/TPA treatment induces senescence and its escape correlates with papillomas formation. Supplementary Figure 5: Validation of H-Ras mutation in papilloma. Supplementary Figure 6: JAK2 is involved in PLA2R1-mediated cell growth regulation. Supplementary Figure 7: PLA2R1 regulates JAK2 activity. -Supplementary Figure 8: JAK2 mediates PLA2R1 tumor suppressive effects.&lt;/p&gt;
CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume (2018)

Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.
Astrocytes mediate cerebral cortical neuronal axon and dendrite growth, in part, by release of fibroblast growth factor (2002)

Astrocytes occupy a central role in central nervous system (CNS) function. In particular astyrocytes can support neurite growth, in part, by release of diffusable factors. We therefore performed biochemical analysis of astrocyte conditioned medium to examine possible mechanisms of astrocyte mediated axon and dendrite growth in the mammalian CNS. Culture medium was conditioned on purified astrocyte monolayers derived from P3 rat cerebral cortex or on fibroblasts. Conditioned medium (CM) was subject to protein denaturation, molecular weight fractionation, and heparin affinity chromatography. E18 mouse cerebral cortical neurons were then cultured in the various media or directly on astrocyte monolayers and axon and dendrite growth from 50 neurons in each condition quantified after 3 DIV using double-labeled immunohistochemical techniques. Axon and dendrite growth was supported by astrocyte CM and both were significantly greater than process growth from neurons incubated in fibroblast CM. Protein denaturation significantly reduced astrocyte CM support of axon and dendrite growth. Following ultrafiltration and dialysis dendrite and axon growth was observed in the molecular weight fraction between 10 and 100 kDa. Axon growth also was observed in the CM molecular weight fraction greater than 100 kDa. Conditioned medium was eluted on a heparin column; when the bound fragment was reconstituted in chemically defined medium extensive dendrite and axon growth was observed. Since fibroblast growth factor (FGF) has these biochemical characteristics we added anti-bFGF neutralizing antibodies to astrocyte monolayers or CM; this significantly reduced astrocyte support of process growth. By contrast, the addition of heparin, which helps activate FGF receptors, to astrocyte CM further enhanced process growth. Western blot analysis confirmed that bFGF was present in astrocyte CM. We then examined axon and dendrite growth from cortical neurons after the addition of various growth factors to chemically defined medium. Axon and dendrite growth, similar to that found in astrocyte CM was observed after the addition of bFGF or aFGF. Astrocyte support of cerebral cortical neuron axon and dendrite growth in vitro may be explained, in part, by FGF release.
On the menbership problem for functional and multivalued dependencies in relational databases (1980)

The problem of whether a given dependency in a database relation can be derived from a given set of dependencies is investigated. We show that the problem can be decided in polynomial time when the given set consists of either multivalued dependencies only or of both functional and multivalued dependencies and the given dependency is also either a functional or a multivalued dependency. These results hold when the derivations are restricted not to use the complementation rule.
AP3 (2004)

This paper describes a cooperative overlay network that provides anonymous communication services for participating users. The Anonymizing Peer-to-Peer Proxy (AP3) system provides clients with three primitives: (i) anonymous message delivery, (ii) anonymous channels, and (iii) secure pseudonyms. AP3 is designed to be lightweight, low-cost and provides "probable innocence" anonymity to participating users, even under a large-scale coordinated attack by a limited fraction of malicious overlay nodes. Additionally, we use AP3's primitives to build novel anonymous group communication facilities (multicast and anycast), which shield the identity of both publishers and subscribers.
Preface (2011)

The following topics are dealt with: visual configuration analytics; formal approaches for global configuration analytics; and automated security management and defence.
LATE-BREAKING ABSTRACT: Treatment of predominant central sleep apnoea with ASV in patients with chronic heart failure: SERVE-HF primary results (2015)

<b>Background:</b> Patients with systolic heart failure (HFrEF) have a high prevalence of sleep-disordered breathing (SDB). Central sleep apnoea (CSA)/Cheyne-Stokes respiration (CSR) is an independent risk factor for poor prognosis and death in HF. The multinational, multicentre, randomised, parallel, event-driven SERVE-HF study (NCT00733343) investigated the effects of treating predominant CSA/CSR with ASV on morbidity and mortality in HFrEF patients. <b>Methods:</b> Patients with HF-rEF and predominant CSA/CSR were randomised to optimal medical management (control) or optimal medical management plus ASV at 91 centres in 11 countries. Clinic visits were scheduled at baseline, after 2 weeks, 3 and 12 months, and then every 12 months. The primary endpoint was the time to first event of all-cause death, unplanned hospitalisation for worsening HF, cardiac transplantation, resuscitation of sudden cardiac arrest or appropriate life-saving shock. Additional assessments included quality of life, NYHA class, 6-minute walk test, plus sleep and breathing parameters. The study was powered for 651 primary endpoints. <b>Results:</b> 1325 patients were enrolled with a median follow-up of 34 months, with the required number of events occurring during this period. Mean age was 69±10 years, 90% male, NYHA class II (30%) or III-IV (70%), LVEF 32±8%, ICD/CRT in 55%, mean apnoea-hypopnoea index 31±13/h (82±18% central events), average nocturnal oxygen saturation 93%, lowest nocturnal oxygen saturation 80%. The effects of ASV on mortality and morbidity will be presented. <b>Conclusion:</b> The clinical implications of the SERVE-HF trial results of ASV in HF-rEF patients will be discussed.
Cobalt-Catalyzed Cross-Coupling Between In Situ Prepared Arylzinc Halides and 2-Chloropyrimidine or 2-Chloropyrazine (2009)

A cobalt-catalyzed cross-coupling of aryl halides with 2-chloropyrimidines or 2-chloropyrazines is reported in satisfactory to high yields. The key step of this procedure is the formation of aromatic organozinc reagents and their coupling with 2-chlorodiazines using the same cobalt halide as catalyst and Zn dust under mild reaction conditions. This new cobalt-catalyzed coupling reaction represents a practical and interesting alternative to previously known methods for the synthesis of 2-aryldiazines.