gebhart/patrepeval huggingface dataset:
Programa de Qualidade na Interação Familiar (PQIF): Orientação e treinamento para pais (2006)

O presente trabalho visou implementar e verificar a eficácia do programa "Promoção da Qualidade de Interação Familiar" (PQIF), que orienta e capacita pais, para que eles mesmos aprendam a manejar as contingências de práticas educativas. Foram 93 pais participantes que tiveram uma porcentagem de presença de 87,9% (média). Os dados quantitativos, obtidos por uma ficha de avaliação, revelaram alta satisfação dos pais. A análise qualitativa dos relatos dos pais demonstrou que os eles passaram por um intenso processo de autoconhecimento e apresentaram mudanças, como: aumento da participação e do desenvolvimento dos pais na vida dos filhos, estabelecimento de regras claras e consistentes, maior valorização de comportamentos adequados dos filhos e aumento da freqüência de elogios por parte dos pais, diminuição ou abandono do uso de palmadas. O programa atingiu seus objetivos, ressaltando que trabalhos de prevenção e intervenção com os pais são necessários para aumento da qualidade na interação familiar
Sustainable Cooling and Lubrication Strategies in Machining Processes: A Comparative Study (2019)

Applying an adequate cooling and lubrication technique during machining processes is an important issue which affects the machining system efficiency. Flood cooling offers an effective solution to reduce the effect of the high heat generated during cutting processes; however, it is not a sustainable strategy because of the health and environmental concerns associated with its utilization. Therefore, several cooling and lubrication strategies have been suggested and used as alternatives to the flood cooling. These strategies include; dry cutting, cryogenic approach, minimum quantity lubrication (MQL), nano-cutting fluids, and MQL-nano-fluids. In this work, a comparative study is presented to evaluate the sustainability effectiveness of these strategies. In order to evaluate the strategies effectiveness, five sustainability indicators are used; namely, energy consumption, personal safety and health, waste management, machining costs, and environmental impact. A weighted decision matrix is developed to assess the studied strategies in terms of the employed sustainable indicators.
In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma. (1998)

In vivo transfection of established tumors with immunostimulatory genes can elicit antitumor immunity. Therefore, we evaluated the safety and efficacy of intratumoral injections of a bacterial superantigen with a cytokine gene in dogs with malignant melanoma, a spontaneous and highly malignant canine tumor. 26 dogs with melanoma were treated with lipid-complexed plasmid DNA encoding staphylococcal enterotoxin B and either GM-CSF or IL-2. Dogs were evaluated for treatment-associated toxicity, tumor responses, immunologic responses, and survival times. The overall response rate (complete or partial remissions) for all 26 dogs was 46% (12 of 26), and was highest in patients with smaller tumors. Toxicity was minimal or absent in all dogs. Injected tumors developed marked infiltrates of CD4+ and CD8+ T cells and macrophages, and tumor regression was associated with development of high levels of antitumor cytotoxic T lymphocyte activity in peripheral blood lymphocytes. Survival times for animals with stage III melanomas treated by intratumoral gene therapy were prolonged significantly compared with animals treated with surgical tumor excision only. Thus, local tumor transfection with superantigen and cytokine genes was capable of inducing both local and systemic antitumor immunity in an outbred animal with a spontaneously developing malignant tumor.
All-small-molecule dynamic covalent hydrogels with multistimuli responsiveness (2019)

All-small-molecule dynamic covalent hydrogels with multistimuli-responsiveness, including temperature, acid, alkali cations and halogen anions.
Epitaxial Growth of Rectangle Shape MoS2 with Highly Aligned Orientation on Twofold Symmetry a‐Plane Sapphire (2020)

Research on transition metal dichalcogenides (TMDs) has been accelerated by the development of large-scale synthesis based on chemical vapor deposition (CVD) growth. However, in most cases, CVD-grown TMDs are composed of randomly oriented grains, and thus contain many distorted grain boundaries (GBs), which seriously degrade their electrical and photoelectrical properties. Here, the epitaxial growth of highly aligned MoS<sub>2</sub> grains is reported on a twofold symmetry a-plane sapphire substrate. The obtained MoS<sub>2</sub> grains have an unusual rectangle shape with perfect orientation alignment along the [1-100] crystallographic direction of a-plane sapphire. It is found that the growth temperature plays a key role in its orientation alignment and morphology evolution, and high temperature is beneficial to the initial MoS<sub>2</sub> seeds rotate to the favorable orientation configurations. In addition, the photoluminescence quenching of the well-aligned MoS<sub>2</sub> grains indicates a strong MoS<sub>2</sub> -substrate interaction which induces the anisotropic growth of MoS<sub>2</sub> , and thus brings the formation of rectangle shape grains. Moreover, the well-aligned MoS<sub>2</sub> grains splice together without GB formation, and thus that has negligible effect on its electrical transport properties. The progress achieved in this work could promote the controlled synthesis of large-area TMDs single crystal film and the scalable fabrication of high-performance electronic devices.
GridPACK: A Framework for Developing Power Grid Simulations on High Performance Computing Platforms (2014)

This paper describes the GridPACK <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> framework, which is designed to help power grid engineers develop modeling software capable of running on high performance computers. The framework makes extensive use of software templates to provide high level functionality while at the same time allowing developers the freedom to express whatever models and algorithms they are using. GridPACK <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> contains modules for setting up distributed power grid networks, assigning buses and branches with arbitrary behaviors to the network, creating distributed matrices and vectors and using parallel linear and non-linear solvers to solve algebraic equations. It also provides mappers to create matrices and vectors based on properties of the network and functionality to support IO and to manage errors. The goal of GridPACK <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> is to substantially reduce the complexity of writing software for parallel computers while still providing efficient and scalable software solutions. The use of GridPACK <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> is illustrated for a simple powerflow example and performance results for powerflow and dynamic simulation are discussed.
EXTH-24. EXPOSURE TO TUMOR TREATING FIELDS INHIBITS DNA REPAIR, INDUCES REPLICATION STRESS AND RENDERS TUMOR CELLS SENSITIVE TO AGENTS THAT IMPINGE UPON THESE PATHWAYS (2018)

Tumor treating fields (TTFields) are low-intensity, intermediate frequency, alternating electric fields applied non-invasively across a tumor. Optune (NovoCure), a TTFields delivery device, has been approved for recurrent and newly diagnosed glioblastoma and clinical trials are ongoing for other cancers. To further understand the molecular mechanisms underlying TTFields sensitivity beyond the anti-mitotic effects already described, we monitored temporal gene expression changes in 5 non-small cell lung cancer (NSCLC) cell lines whose response to TTFields is variable. We found the expression of the BRCA1 DNA damage repair pathway, as well as other DNA repair/checkpoint pathways were significantly downregulated (P<0.05). Quantitative measurement of DNA double strand break repair revealed that TTFields treatment slowed the repair of ionizing radiation (IR)-induced DNA damage and interestingly, TTFields alone increased the number of γH2AX foci and the incidence of chromatid aberrations. Furthermore, as a function of TTFields exposure time, the length of newly replicated DNA was shorter and R-loop formation increased, suggesting that TTFields induce replication stress. Based on these newly identified mechanisms of TTFields action in DNA damage and replication stress pathways we hypothesized that by applying TTFields first, a conditional vulnerability environment would develop rendering cells more susceptible to agents such as radiation, cisplatin, or PARP inhibition. In agreement with our hypothesis, NSCLC cell susceptibility to radiation increased when cells were exposed to TTFields prior to IR treatment compared to IR treatment followed by TTFields. Furthermore, we found that the effect of TTFields exposure concomitant with the PARP inhibitor Olaparib followed by radiation was synergistic compared to radiation or Olaparib alone or in combination, although the degree of sensitization and synergy varied across the different cell lines. Based upon these results we suggest the clinical use of TTFields as neoadjuvant therapy prior to radiation treatment and either prior to or concomitant with chemotherapy agents.
A Technique for Capturing Migratory Periocular Worms: A Case Series and Review of Literature (2010)

A sense of urgency is conveyed to isolate the migratory worm while it is still visible and residing in a location for easy surgical removal. The retreat of the worm to the deeper, inaccessible orbit is prevented by strategic placement of a perimeter of anesthetic.
Biochemical IC chip toward cell free DNA protein synthesis (2002)

The several type of biochemical IC chips with photo detective micro reactor has been developed. The real time monitoring and controlling cell free synthesis of protein was demonstrated successfully. The photo protein of firefly so called Luciferase was synthesized. The biochemical luminescence was monitored by built-in photo diode in the micro reactor to transfer reaction status into voltage signal. Feedback control synthetic reaction was verified experimentally. The results achieved here should be key technology for future DNA and RNA synthesis without biological cell.
Elution-free DNA detection using CRISPR/Cas9-mediated light-up aptamer transcription: Toward all-in-one DNA purification and detection tube (2023)

Accurate and efficient detection of DNA is crucial for disease diagnosis and health monitoring. The traditional methods for DNA analysis involve multiple steps, including sample preparation, lysis, extraction, amplification, and detection. In this study, we present a one-step elution-free DNA analysis method based on the combination of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated light-up aptamer transcription (CLAT) assay and a DNA-capturing poly(2-dimethylaminomethyl styrene) (pDMAMS)-coated tube. The sample solution and lysis buffer are added to the pDMAMS-coated tube, and the DNA is efficiently captured on the surface via electrostatic interaction and directly detected by CLAT assay. The ability of the CRISPR/Cas9 system to specifically recognize DNA enables direct detection of DNA captured on the pDMAMS-coated tube. The combination of CLAT assay and pDMAMS-coated tube simplifies DNA detection in a single tube without the need for complicated extraction steps, improving sensitivity. Our platform demonstrated attomolar sensitivity in the detection of target DNA in cell lysate (0.92 aM), urine (7.7 aM), and plasma (94.6 aM) samples within 1 h. The practical applicability of this method was further demonstrated in experiments with tumor-bearing mice. We believe that this approach brings us closer to an all-in-one DNA purification and detection tube system and has potential applications in tissue and liquid biopsies, as well as various other DNA sensing applications.
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas (2019)

Defective DNA damage response (DDR) is frequently associated with tumorigenesis. Abrogation of DDR leads to genomic instability, which is one of the most common characteristics of human cancers. <i>TP53</i> mutations with gain-of-function activity are associated with tumors under high replicative stress, high genomic instability, and reduced patient survival. The <i>BRCA1</i> and <i>RAD17</i> genes encode two pivotal DNA repair proteins required for proper cell-cycle regulation and maintenance of genomic stability. We initially evaluated whether miR-205-5p, a microRNA (miRNA) highly expressed in head and neck squamous cell carcinoma (HNSCC), targeted BRCA1 and RAD17 expression. We found that, in vitro and in vivo, <i>BRCA1</i> and <i>RAD17</i> are targets of miR-205-5p in HNSCC, leading to inefficient DNA repair and increased chromosomal instability. Conversely, miR-205-5p downregulation increased BRCA1 and RAD17 messenger RNA (mRNA) levels, leading to a reduction in in vivo tumor growth. Interestingly, miR-205-5p expression was significantly anti-correlated with <i>BRCA1</i> and <i>RAD17</i> targets. Furthermore, we documented that miR-205-5p expression was higher in tumoral and peritumoral HNSCC tissues than non-tumoral tissues in patients exhibiting reduced local recurrence-free survival. Collectively, these findings unveil miR-205-5p's notable role in determining genomic instability in HNSCC through its selective targeting of BRCA1 and RAD17 gene expression. High miR-205-5p levels in the peritumoral tissues might be relevant for the early detection of minimal residual disease and pre-cancer molecular alterations involved in tumor development.
Hybrid Si3N4-Graphene Nanophotonic Circuits for Electro-Optic Modulation (2014)

We present graphene-based optical modulators integrated with Si3N4 waveguides which provide broadband flat absorption from visible to infrared wavelengths. Tunable attenuation of 0.067 dB/μm is measured in Mach-Zehnder interferometers and microring resonators.
Taurolin, a New Chemotherapeutic Agent (1976)

Taurolin, bis‐(1,1‐dioxo‐perhydro‐1,2,4‐thiadiazinyl‐4)‐methan, is a novel, broad spectrum, non‐systemic chemotherapeutic agent. It is effective in vivo against a wide range of pathogenic organisms including Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris , and Salmonella typhimurium , and would be of particular use against antibiotic‐resistant organisms. It is based on an endogenous substance, taurine, which acts as a non‐toxic formaldehyde carrier donating methylol groups to bacterial protein and endotoxin thus causing denaturation and polycondensation of the pathogens and their pyrogens. It is anticipated that Taurolin will be of value in the treatment of faecal peritonitis.
The use of fuzzy integrals and bispectral analysis of the electroencephalogram to predict movement under anesthesia (1999)

The objective of this study was to design and evaluate a methodology for estimating the depth of anesthesia in a canine model that integrates electroencephalogram (EEG)-derived autoregressive (AR) parameters, hemodynamic parameters, and the alveolar anesthetic concentration. Using a parameters, and the alveolar anesthetic concentration. Using a parametric approach, two separate AR models of order ten were derived for the EEG, one from the third-order cumulant sequence and the other from the autocorrelation lags of the EEG. Since the anesthetic dose versus depth of anesthesia curve is highly nonlinear, a neural network (NN) was chosen as the basic estimator and a multiple NN approach was conceived which took hemodynamic parameters, EEG derived parameters, and anesthetic concentration as input feature vectors. Since the estimation of the depth of anesthesia involves cognitive as well as statistical uncertainties, a fuzzy integral was used to integrate the individual estimates of the various networks and to arrive at the final estimate of the depth of anesthesia. Data from 11 experiments were used to train the NN's which were then tested on nine other experiments. The fuzzy integral of the individual NN estimates (when tested on 43 feature vectors from seven of the nine test experiments) classified 40 (93%) of them correctly, offering a substantial improvement over the individual NN estimates.
Breast-feeding: nature's contraceptive. (1985)

Our ancestors achieved the lowest rate of reproduction of any living mammal by the postponement of puberty until well into the 2nd decade of life, a maximal probability of conception of only about 24% per menstrual cycle even when ovulation had commenced, a 4-year birth interval as a result of the contraceptive effects of breastfeeding, and sharply declining fertility during the 4th decade of life, leading to complete sterility at the menopause. This pattern of reproduction was ideally suited to the prevailing lifestyle of the nomadic hunter-gatherer. The postponement of puberty resulted in a prolonged period of childhood dependency, thus enabling parents to transmit their acquired experience to their offspring. Long birth intervals were essential for a woman who had to wander 1000 or more miles each year in search of food, because she could not manage to carry more than 1 child with her at a time. The lifestyle of comparatively recent times of a settled agricultural economy made possible subsequent rural and urban development, but this transition from nomad to city dweller also stimulated fertility. The cultivation of crops and the domestication of animals led to the development of permanent housing, where the mother could leave her baby in a safe place while she worked in the field. The resultant reduction in mother-infant contact coupled with the availability of early weaning foods reduced the suckling frequency, thereby eroding the contraceptive effect of breastfeeding and decreasing the birth interval. The model conquest of disease eventually led to rapid rates of population growth. In the developed countries of Europe and North America, reproduction was subsequently held in check by the use of artificial forms of contraception, but this has yet to take place in the developing countries of Asia, Africa, and South America. For a developing country, contraceptives are expensive, may be culturally unacceptable, and carry health risks. Breastfeeding is 1 form of contraception that should be culturally acceptable to all societies. Breastfeeding is preferable to natural family planning methods, because the contraceptive protection afforded by breastfeeding requires no equipment apart from a baby and places no constraints on intercourse at any time. There is no question which of the two represents the more natural form of family planning. Clearly, breastfeeding is nature's contraceptive.
MSR-NLP Entry in BioNLP Shared Task 2011 (2011)

We describe the system from the Natural Language Processing group at Microsoft Research for the BioNLP 2011 Shared Task. The task focuses on event extraction, identifying structured and potentially nested events from unannotated text. Our approach follows a pipeline, first decorating text with syntactic information, then identifying the trigger words of complex events, and finally identifying the arguments of those events. The resulting system depends heavily on lexical and syntactic features. Therefore, we explored methods of maintaining ambiguities and improving the syntactic representations, making the lexical information less brittle through clustering, and of exploring novel feature combinations and feature reduction. The system ranked 4th in the GENIA task with an F-measure of 51.5%, and 3rd in the EPI task with an F-measure of 64.9%.
Migration of EndoButton After Anatomic Double‐Bundle Anterior Cruciate Ligament Reconstruction (2011)

Level IV, prognostic case series.
Toughness and Effective Grain Size in Heat-Treated Low-Alloy High Strength Steels (1972)

It has been found that the toughness of heat-treated steels is closely related to the" elfective grain size", which is defined as the size of the region which cleavage cracks propagate through in a nearly straight fashion .
Improvement in the Therapeutic Ratio of Radiotherapy for a Murine Sarcoma by Indomethacin Plus Fludarabine (1996)

Fludarabine, an effective repair inhibitor of radiation-induced chromosome breaks, and indomethacin, an inhibitor of prostaglandin synthesis, were shown previously to improve the therapeutic ratio of radiotherapy for murine tumors. The purpose of this study was to determine whether the combination of these two radiosensitizers with different mechanisms of action could further increase the therapeutic ratio of radiotherapy in an FSA mouse sarcoma after single and fractionated irradiation. The effect of the combined treatment on tumors was assessed by the local tumor control assay (TCD50) in mice bearing an FSA sarcoma in the leg. The effect of the combination on normal tissues was assessed by skin desquamation, hair loss and leg contracture in the legs of non-tumor-bearing mice. For the TCD50 assay, after single irradiation, the radiation dose modification factor (DMF) reached 1.2 for both indomethacin (35 micrograms/ml in the drinking water for 10 days) and fludarabine (800 mg/kg intraperitoneally 3 h prior to irradiation). For both drugs combined, the DMF increased to 1.7. No significant increase in normal tissue toxicity was observed with any of the combinations. After fractionated irradiation (16 fractions over 4 days), the DMFs for local tumor control reached 1.3 for indomethacin and 1.8 for fludarabine darabine (400 mg/kg every day for 4 days). The combination of both drugs produced a DMF of 2.0. None of the combinations altered the effects of radiation on skin desquamation, hair loss or leg contracture significantly. The present study suggests that the therapeutic ratio of radiotherapy for a murine sarcoma can be improved by the combination of indomethacin and fludarabine, two agents differing in their mechanisms of radiopotentiation.
Studies of individual amino acid residues of the decapeptide tyrocidine A by proton double-resonance difference spectroscopy in the correlation mode (1975)

The cyclic decapeptide antibiotic tyrocidine A was studied by two relatively new methods, viz., correlation proton magnetic resonance (pmr) spectroscopy and double-resonance difference pmr spectroscopy. The correlation method of spectral accumulation provided pmr spectra of good resolution, and in addition the signal-to-noise ratio achieved per unit time of accumulation was much higher than that achieved by use of the conventional continuous wave (cw) method. Furthermore, when protonated solvents are used, the correlation mode of accumulation has a distinct advantage over pulse and fast Fourier transform (fft) methods currently in use. Double-resonance difference (drd) spectra of individual amino acid residues in tyrocidine A were obtained by the correlation method when the decoupling frequency was maintained at the center frequency of the appropriate C-alpha proton multiplet and at a level of power that totally decoupled vicinal C-alpha and C-beta protons; the resolution of these spectra was good, and the signal-to-noise ratio was high. The distinct patterns and spectral positions of the drd spectra were characteristic of the particular type of amino acid residue and, therefore, could be used as the basis for making assignments. Furthermore, the drd spectra revealed the spectral positions of individual C-alpha and C-beta proton transitions and therefore, upon spectral analysis, could provide the chemical shifts and coupling constants of these protons. Positions of transitions were revealed even though they were hidden by overlap in the corresponding conventional single- or double-resonance spectra.