gebhart/patrepeval huggingface dataset:
Effect of Phytocannabinoids on Nausea and Vomiting (2014)

Abstract Among over 60 terpeno-phenols derived from the cannabis plant, delta-9-tetrahydrocannabinol (Δ9-THC) has by far been the most studied for its potential to reduce nausea and vomiting. Indeed, the first approved medical use of Δ9-THC was for nausea and vomiting. However, the remaining compounds in the plant have received relatively less investigation. This chapter reviews recent research on the potential of the phytocannabinoids, cannabidiol (CBD), cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), cannabivarin (CBDV), and cannabigerol (CBG) to reduce nausea and vomiting in animal models. CBD and CBDA attenuate nausea and vomiting via indirect agonism of the 5-HT1A receptor, while CBG acts as a 5-HT1A receptor antagonist, reversing the suppressive effect of CBD on nausea and vomiting. THCA potently reduces nausea and vomiting, possibly by a CB1 receptor mechanism of action. Finally, CBDV, as well as a high dose of THCV, also attenuate nausea. These phytocannabinoids have therapeutic potential that merits further exploration.
Performance validation of a multi-standard and multi-antenna receiver (2006)

This paper assesses the efficiency of a multi standard and multi antenna receiver using simulation and test measurements in a real propagation environment. A multi-standard and multi-antenna receiver is firstly designed with the ADS© software. Secondly, the performance of this system is evaluated with several multi-antenna algorithms, under real radio propagation conditions depending on the standard we choose to deal with. At this time the receiver can run with 802.11b and 802.11g standards in a 36 MHz bandwidth. Some first results are presented using multi antenna algorithm in a receiver dealing with two 802.11g or 802.11b transmission on overlapped communication channels.
Clinical Results of Mean GTV Dose Optimized Robotic-Guided Stereotactic Body Radiation Therapy for Lung Tumors (2018)

Robotic SBRT is a safe and effective treatment for lung tumors. Reducing the PTV prescription and keeping high GTV mean doses allowed the reduction of toxicity while maintaining high local tumor control. The use of real-time motion compensation is strongly advised, however, well-performed ITV motion compensation may be used alternatively when direct tracking is not feasible.
Stereospecific introduction of functionalized angular methyl groups via the Claisen rearrangement. Octalin and hydrindenyl ring systems (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific introduction of functionalized angular methyl groups via the Claisen rearrangement. Octalin and hydrindenyl ring systemsWilliam G. Dauben and Thomas J. DietscheCite this: J. Org. Chem. 1972, 37, 8, 1212–1216Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://pubs.acs.org/doi/10.1021/jo00973a030https://doi.org/10.1021/jo00973a030research-articleACS PublicationsRequest reuse permissionsArticle Views287Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 3D Nanostructured Hydrogel‐Framework‐Derived High‐Performance Composite Polymer Lithium‐Ion Electrolyte (2018)

Abstract Solid‐state electrolytes have emerged as a promising alternative to existing liquid electrolytes for next generation Li‐ion batteries for better safety and stability. Of various types of solid electrolytes, composite polymer electrolytes exhibit acceptable Li‐ion conductivity due to the interaction between nanofillers and polymer. Nevertheless, the agglomeration of nanofillers at high concentration has been a major obstacle for improving Li‐ion conductivity. In this study, we designed a three‐dimensional (3D) nanostructured hydrogel‐derived Li 0.35 La 0.55 TiO 3 (LLTO) framework, which was used as a 3D nanofiller for high‐performance composite polymer Li‐ion electrolyte. The systematic percolation study revealed that the pre‐percolating structure of LLTO framework improved Li‐ion conductivity to 8.8×10 −5 S cm −1 at room temperature.
The challenge of preventing environmentally related disease in young children: community-based research in New York City. (2002)

Rates of developmental and respiratory diseases are disproportionately high in underserved, minority populations such as those in New York City's Washington Heights, Harlem, and the South Bronx. Blacks and Latinos in these neighborhoods represent high risk groups for asthma, adverse birth outcomes, impaired development, and some types of cancer. The Columbia Center for Children's Environmental Health in Washington Heights uses molecular epidemiologic methods to study the health effects of urban indoor and outdoor air pollutants on children, prenatally and postnatally, in a cohort of over 500 African-American and Dominican (originally from the Dominican Republic) mothers and newborns. Extensive data are collected to determine exposures to particulate matter < 2.5 microm in aerodynamic diameter (PM(2.5)), polycyclic aromatic hydrocarbons (PAHs), diesel exhaust particulate (DEP), nitrogen oxide, nonpersistent pesticides, home allergens (dust mite, mouse, cockroach), environmental tobacco smoke (ETS), and lead and other metals. Biomarkers, air sampling, and clinical assessments are used to study the effects of these exposures on children's increased risk for allergic sensitization, asthma and other respiratory disorders, impairment of neurocognitive and behavioral development, and potential cancer risk. The center conducts its research and community education in collaboration with 10 community-based health and environmental advocacy organizations. This unique academic-community partnership helps to guide the center's research so that it is most relevant to the context of the low-income, minority neighborhoods in which the cohort resides, and information is delivered back to these communities in meaningful ways. In turn, communities become better equipped to relay environmental health concerns to policy makers. In this paper we describe the center's research and its academic-community partnership and present some preliminary findings.
Steady-state analysis of a doubly fed asynchronous machine supplied by a current-controlled cycloconvertor in the rotor (1992)

This paper deals with a doubly fed asynchronous machine (DFAM) supplied by a current-controlled cycloconvertor (CCC) at the rotor, and AC mains at the stator. A microprocessor is used to achieve control of the system by magnitude, frequency or phase shift of the output currents of the cycloconvertor. It also ensures the bank selection process. The mathematical model of the DFAM presented is based on a vectorial representation. Steady-state analysis of the CCC-fed DFAM has been carried out in the synchronous reference frame, and expressions of various output variables are developed. Performances of the drive are determined analytically. After theoretical analysis, the effect of the control parameters is investigated. Experimental results obtained show a good correlation with analytical predictions. Moreover, the range of variations of load angle must be limited to be within a certain value to verify stability conditions, and currents must not exceed the upper limits that the machine can carry.
DHPLC Scoring of a SNP between Promoter Sequences of HMW Glutenin x-type Alleles at the Glu-D1 Locus in Wheat (2003)

The promoter regions of HMW glutenin x-type genes at the Glu-D1 locus were surveyed for SNPs within a subpopulation of German bread wheat cultivars. On the basis of the promoter sequences of HMW glutenin subunit genes Glu-A1-x1, Glu-A1-x2, Glu-B1-x1, Glu-B1-x7, Glu-D1-x2, and Glu-D1-x5, an amplification refractory mutation system assay was designed to selectively amplify Dx-specific PCR fragments. Comparative sequence analysis among seven Glu-D1-x2 and seven Glu-D1-x5 wheat cultivars only confirmed a G-A transition in the promoter sequence to be a true polymorphism. SNP scoring by DHPLC of 95 German bread wheat cultivars, with the exception of cv. Anemos, showed that the transition completely agreed with the presence of HMW glutenin subunits 1Dx5 + 1Dy10 in SDS-PAGE. Therefore, the developed DHPLC assay is suitable for high-throughput genotyping to assist the selection of HMW glutenin genes in wheat quality breeding programs.
Supplementary Methods and Materials from RalA Function in Dermal Fibroblasts Is Required for the Progression of Squamous Cell Carcinoma of the Skin (2023)

Supplementary Methods and Materials from RalA Function in Dermal Fibroblasts Is Required for the Progression of Squamous Cell Carcinoma of the Skin
Compilation of BPMN-based Integration Flows (2015)

Enterprise Application Integration plays an integral role for the communication between applications not only in service-oriented architectures. However, their modeling and configuration remain under- represented. In previous work, the integration control and data flow syntax and semantics have been expressed in the Business Process Model and Notation (BPMN) as a semantic model for message-based integration, while the concrete compilation to several runtime systems was left open. In this work we share our ideas for a general compilation approach along the Message Redelivery on Exception (MRoE) integration capability and basic message processing strategies, from which we derive compilation patterns. These patterns are used to translate BPMN models via an inter- mediate property graph model to a runtime system graph representation that allows the generation of executable runtime code.
A reliable dual Blumlein device (1989)

In this article, we describe the 500 kV, 100 kA (each arm) GEMINI dual Blumlein accelerator at the Air Force Weapons Laboratory. Novel isolation, trigger, and trigger timing techniques are utilized in this device in order to allow two Blumleins to be charged by one Marx generator, and discharged at different times. The timing circuits are unique in that they make use of saturable magnetic circuits to provide the relative timing of the two outputs. We demonstrate that this technique is reliable, reproducible, and straightforward. We isolate the two Blumlein switches using an inductor wound so that it has minimal inductance when both Blumleins are charging, but maximum inductance when one is fired and the second Blumlein is delayed. Utilization of this technique allows us to isolate the two Blumleins without using resistive isolation with its associated energy loss, or simple inductive isolation with the associated cost in increasing the water line charge time. Complete operational and design data is presented, along with detailed data from the switch trigger arms.
GPU-accelerated deep shadow maps for direct volume rendering (2006)

Deep shadow maps unify the computation of volumetric and geometric shadows. For each pixel in the shadow map, a fractional visibility function is sampled, pre-filtered, and compressed as a piecewise linear function. However, the original implementation targets software-based off-line rendering. Similar previous algorithms on GPUs focus on geometric shadows and lose many important benefits of the original concept. We focus on shadows for interactive direct volume rendering, where shadow algorithms currently either compute additional per-voxel shadow data, or employ half-angle slicing to generate shadows during rendering. We adapt the original concept of deep shadow maps to volume ray-casting on GPUs, and show that it can provide anti-aliased high-quality shadows at interactive rates. Ray-casting is used for both generation of the shadow map data structure and actual rendering. High frequencies in the visibility function are captured by a pre-computed lookup table for piecewise linear segments. Direct volume rendering is performed with an additional deep shadow map lookup for each sample. Overall, we achieve interactive high-quality volume ray-casting with accurate shadows. To conclude, we briefly describe how semi-transparent geometry such as hair could be integrated as well, provided that rasterization can write to arbitrary locations in a texture. This would be a major step toward full deep shadow map functionality.
Specific DNA rearrangements in synchronously developing nuclei of Tetrahymena. (1984)

Specific rearrangement of internal chromosomal regions occurs during development of the somatic macronucleus in Tetrahymena thermophila and results in elimination of germ-line (micronuclear) DNA sequences. The timing and mechanism of genome rearrangement within one particular 9.3-kilobase region, which contains three distinct eliminated sequences, were investigated. Portions of this cloned region were used as probes in Southern hybridization experiments to analyze DNA from developing macronuclei (anlagen). All three deletions were found to occur predominantly within a 2-hr time period in which the nuclear DNA contents increased from 4C to 8C (1C represents the amount of DNA present in a haploid genome). The three deletion events can occur independently because intermediate forms, having sustained one or two deletions, were detected. One of the deletions occurs in two alternative ways, resulting in two equally abundant products of different size. Because reciprocal products expected from unequal sister chromatid exchange were not detected, an intramolecular DNA splicing mechanism is suggested.
Wheelchair-mounted robotic arm to hold and move a communication device - final design. (2015)

At the 51st Rocky Mountain Bioengineering Symposium we presented a preliminary design for a robotic arm to assist an individual living within an assistive technology smart home. The individual controls much of their environment with a Dynavox Maestro communication device. However, the device obstructs the individuals line of site when navigating about the smart home. A robotic arm was developed to move the communication device in and out of the users field of view as desired. The robotic arm is controlled by a conveniently mounted jelly switch. The jelly switch sends control signals to a four state (up, off, down, off) single-axis robotic arm interfaced to a DC motor by high power electronic relays. This paper describes the system, control circuitry, and multiple safety features. The arm will be delivered for use later in 2015.
Change in cross-sectional area of the spinal cord and canal in healthy and scoliotic adolescents over a one year time period (2017)

In Adolescent Idiopathic Scoliosis (AIS) the cross-sectional area of the spinal cord and spinal canal is of clinical importance when inserting pedicle screws. Few studies have measured the size of the canal and cord in adolescents, or how they change over time. This study quantified the axial cross-sectional area of both the spinal cord and spinal canal in healthy adolescents and those with AIS over time.
New FSO ATP methods for compact space subsystems (2017)

Our current and future Free Space Optical (FSO) designs and performance will be presented; Acquisition, Tracking, and Pointing (ATP) will be a key focus along with the size, weight and power (SWaP) of our existing ground systems and our design targets for space applications. Without gimbals, Rislet prisms, steering mirrors, or off-optical-z-axis sensing, and with only five static non-moving optical elements, we simply move an optical fiber in the focal plane to track the input and output beam angles over the entire wide range pointing field in both azimuth and elevation. Our optical design uses only five statically mounted elements. Fine pointing accuracies are sustained over the entire field without the use of coarse pointing and control systems. The impacts on SWaP are significant, and greatly simplify the packaging and ATP control systems. Our bi-directional ground-links have operated from 1 to 10 Gbps with link distances from 1 to 10 km. The primary ground systems that were delivered had ATP fields of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> or 30 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> in both azimuth and elevation. For the 30 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> system, the pointing resolution is 470 nano-radian, while the 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> system provides 147 nano-radian pointing resolution. We also discuss the performance of our ground links and anticipated performance for various space applications.
Hydrophone guided transcranial beam steering (2001)

A new method for focusing ultrasound energy in brain tissue through the skull bone is investigated. The procedure is designed for use with a multielement therapeutic transducer array and a small catheter-inserted hydrophone receiver placed in the brain in order to guide the array’s focus over a volume of tissue about the receiver. When performed at high intensity, cells within this volume are destroyed. The present study tests the feasibility and range of the method using ex vivo human skulls. The skull is placed between a focused ultrasound array and the receiver. Acoustic phase information is obtained from the receiver and used to both electrically shift the beam to new locations as well as correct aberrations due to the skull bone. The method is applied to a 104-element 1.1-MHz array and 120 elements of a 500-element 0.81-MHz array. Using these array configurations it is determined that the method can reconstruct and steer a focus over a distance of 60 mm within the brain. Application of this minimally invasive technique for ultrasound brain therapy and surgery is also demonstrated.
Metabolism of Cytokinin (1978)

As part of the study of cytokinin metabolic pathways, an enzyme, adenosine phosphorylase (EC 2.4.2.-), which catalyzed the ribosylation of N(6)-(Delta(2)-isopentenyl)adenine, N(6)-furfuryladenine, and adenine to form the corresponding nucleosides, was partially purified from wheat (Triticum aestivum) germ. The pH optimum for the ribosylation of the cytokinins and adenine was from 6.5 to 7.8; for guanine and hypoxanthine it was from 7.0 to 8.5 At pH 7.2 (63 millimolar N-2-hydroxyethyl piperazine-N'-ethanesulfonic acid) and 37 C the K(m) for N(6)-(Delta(2)-isopentenyl)adenine was 57.1 micromolar; N(6)-furfuryladenine, 46.5 micromolar; adenine, 32.2 micromolar; and the V(max) for N(6)-(Delta(2)-isopentenyl)adenine, N(6)-furfuryladenine, and adenine were 134.7, 137.1, and 193.1 nanomoles per milligram protein per minute, respectively. The equilibrium constants of the phosphorolysis of N(6)-(Delta(2)-isopentenyl)adenosine and adenosine by this enzyme indicated that the reaction strongly favored nucleoside formation. This enzyme was shown to be distinct from inosine-guanosine phosphorylase based on the differences in the Sephadex G-100 gel filtration behaviors, pH optima, and the product and p-hydroxymercuribenzoate inhibitor studies. These results suggest that adenosine phosphorylase may play a significant role in the regulation of cytokinin metabolism.
Contact Dermatitis due to Nitroglycerin Ointment (1979)

Topical nitroglycerin ointment is among the most effective long-acting vasodilators currently available. We report two cases of contact dermatitis in which patch testing showed allergy to nitroglycerin-containing compounds. The severity of this dermatitis necessitated the discontinuation of topical nitroglycerin therapy in both patients. A potent corticosteroid cream applied once to previous nitroglycerin application sites prevented or minimized this dermatitis and enabled continuation of topical nitroglycerin therapy. Contact dermatitis due to topical nitroglycerin preparations may be more common than is presently realized.
Utilization of bone densitometry for prediction and administration of bisphosphonates to prevent osteoporosis in patients with prostate cancer without bone metastases receiving antiandrogen therapy (2014)

Contrary to the recommendations, bone densitometry and bisphosphonate therapy are underutilized in men receiving ADT for non-metastatic prostate cancer.
Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer (2019)

Hyaluronan (HA) and collagen are highly expressed in pancreatic cancer (PC) stroma. HA and collagen accumulation increase tumor interstitial fluid pressure, compromising blood flow and drug penetration. The aim of this biomarker study was to determine the clinical utility of serum HA and the propeptide of type III collagen (PRO-C3) in patients with PC. A cohort from the Danish BIOPAC study (NCT03311776) including patients with histologically confirmed pancreatic ductal adenocarcinoma (n = 809), ampullary carcinoma (n = 44), distal biliary tract cancer (n = 31), chronic pancreatitis (n = 15), intraductal papillary mucinous neoplasm (n = 41), duodenal adenoma (n = 7) and no cancer (n = 25). Healthy controls were available for serum HA (n = 141) and PRO-C3 (n = 8). The main outcome was overall survival (OS) of patients with PC in relation to pretreatment serum HA and PRO-C3 levels. Patients with PC had higher baseline serum HA and PRO-C3 than healthy subjects and patients with benign conditions. Pretreatment serum baseline HA and PRO-C3 in patients with PC were associated with poorer survival and PRO-C3 remained prognostic also after adjusting for age, performance status, stage, the presence of liver and peritoneum metastasis, and CA19-9. Detection of HA and PRO-C3 may be useful in differentiating between malignant and benign pancreatic conditions. Serum HA and PRO-C3 were prognostic for OS in patients with PC.
The user edit: Making manuals easier to use (1981)

Possibly the simplest way to make a technical manual easier to use is a “user edit” — that is, having an inexperienced user try to work with a machine, using only its manual as a guide. His errors and hesitations should tell you where the weak points are. This report describes how to set up such tests, what to be careful of, and some of the benefits you can expect.
Florbetapir (F18‐AV‐45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging (2013)

: The data are consistent with expected rates of amyloid positivity among individuals with clinical diagnoses of AD and MCI, and indicate the potential value of florbetapir F18 PET as an adjunct to clinical diagnosis.