gebhart/patrepeval huggingface dataset:
Environmental and Growth Phase Regulation of the Streptococcus gordonii Arginine Deiminase Genes (2008)

A 1,026-bp open reading frame sharing significant similarity with queA, which encodes a predicted S-adenosylmethionine:tRNA ribosyltransferase-isomerase responsible for queosine modification of tRNAs, was found immediately 5' of the gene for the transcriptional activator (ArcR) of the arginine deiminase system (ADS) operon of Streptococcus gordonii. The role of QueA in bacterial physiology is enigmatic, but loss of QueA has been shown to compromise stationary-phase survival or virulence in certain enteric bacteria. Interestingly, S. gordonii appears to be unique among ADS-positive bacteria in the linkage of queA with the ADS genes. A putative sigma(70) promoter (p(queA); TTGCCA-N(21)-TATAAT) was mapped 5' of queA by primer extension, and queA and arcR were shown to be cotranscribed. The expression from p(queA) was found to be constitutive under all conditions tested, but the expression of p(arcA), which drives the expression of the arc structural genes, was enhanced in stationary phase and could be induced by low pH and arginine. QueA and CcpA acted repressively on arc transcription, but neither QueA-deficient strains nor CcpA-deficient strains showed significant differences in arginine deiminase enzyme activities compared with the wild-type strain. The growth rate of a QueA-deficient strain did not differ significantly from that of the parental strain, but the QueA-deficient strain did not compete well with the wild-type during serial passage. In addition to the finding that ADS expression can be regulated separately by growth phase and pH, a significant linkage between the ADS, translational efficiency modulated by QueA, and post-exponential-phase survival of S. gordonii was found.
Identification of Potential Antimicrobial Targets of Pseudomonas aeruginosa Biofilms through a Novel Screening Approach (2023)

<i>Pseudomonas aeruginosa</i> is an opportunistic pathogen of considerable medical importance, owing to its pronounced antibiotic tolerance and association with cystic fibrosis and other life-threatening diseases. The aim of this study was to highlight the genes responsible for <i>P. aeruginosa</i> biofilm tolerance to antibiotics and thereby identify potential new targets for the development of drugs against biofilm-related infections. By developing a novel screening approach and utilizing a public <i>P. aeruginosa</i> transposon insertion library, several biofilm-relevant genes were identified. The Pf phage gene (<i>PA0720</i>) and flagellin gene (<i>fliC</i>) conferred biofilm-specific tolerance to gentamicin. Compared with the reference biofilms, the biofilms formed by <i>PA0720</i> and <i>fliC</i> mutants were completely eliminated with a 4-fold-lower gentamicin concentration. Furthermore, the <i>mreC</i>, <i>pprB</i>, <i>coxC</i>, and <i>PA3785</i> genes were demonstrated to play major roles in enhancing biofilm tolerance to gentamicin. The analysis of biofilm-relevant genes performed in this study provides important novel insights into the understanding of <i>P. aeruginosa</i> antibiotic tolerance, which will facilitate the detection of antibiotic resistance and the development of antibiofilm strategies against <i>P. aeruginosa</i>. <b>IMPORTANCE</b> <i>Pseudomonas aeruginosa</i> is an opportunistic pathogen of high medical importance and is one of the main pathogens responsible for the mortality of patients with cystic fibrosis. In addition to inherited antibiotic resistance, <i>P. aeruginosa</i> can form biofilms, defined as communities of microorganisms embedded in a self-produced matrix of extracellular polymeric substances adhering to each other and/or to a surface. Biofilms protect bacteria from antibiotic treatments and represent a major reason for antibiotic failure in the treatment of chronic infections caused by cystic fibrosis. Therefore, it is crucial to develop new therapeutic strategies aimed at specifically eradicating biofilms. The aim of this study was to generalize a novel screening method for biofilm research and to identify the possible genes involved in <i>P. aeruginosa</i> biofilm tolerance to antibiotics, both of which could improve the understanding of biofilm-related infections and allow for the identification of relevant therapeutic targets for drug development.
Microwave Heating: A New Approach of Simulation and Validation (2006)

Abstract Currently the distribution of microwave processes in industrial applications is sparsely spread. Reasons for this are, in particular, the inhomogeneous heating patterns and the lack of optimization potential, due to the lack of possibilities for simulation of coupled electromagnetic and thermal processes. In this work two commercial software packages have therefore been coupled to simulate local and time specified temperature distributions of microwave treated samples. The results are validated by the sophisticated magnetic resonance imaging (MRI) technique, in order to avoid the problems of measuring temperature distributions in microwave fields. This method of measurement is non‐invasive, shows high 3D spatial and time resolutions, and does not influence the electromagnetic field.
Restoration of Fermi Liquid State in CeCoIn5: Evidence for Field-Induced Quantum Critical Point (2002)

The resistivity of the heavy-fermion superconductor CeCoIn5 was measured as a function of temperature, down to 25 mK and in magnetic fields of up to 16 T applied perpendicular to the basal plane. With increasing field, we observe a suppression of the non-Fermi liquid behavior, rho ~ T, and the development of a Fermi liquid state, with its characteristic rho = rho_0 + AT^2 dependence. The field dependence of the T^2 coefficient shows critical behavior with an exponent of 1.37. This is evidence for a field-induced quantum critical point (QCP), occuring at a critical field which coincides, within experimental accuracy, with the superconducting critical field H_c2. We discuss the relation of this field-tuned QCP to a change in the magnetic state, seen as a change in magnetoresistance from positive to negative, at a crossover line that has a common border with the superconducting region below ~ 1 K.
Effects of canard shape on the center of pressure of a generic missile configuration (2000)

An experimental investigation is conducted to study the effects of canard shape on the center of pressure location of a generic canard-wing-body configuration. The aspect ratio, sweep angle and taper ratio of canards having constant planform area are systematically varied. The aspect ratio is varied from 2 to 10. The taper ratio is varied form 0 to 1 and the sweep angle is varied from - 15’ to +45’. The aerodynamic loads on the configurations are measured with a 6-component balance. All tests are conducted in the subsonic wind tunnel at the USAF Academy, at a Mach number of 0.5 and at angles of attack of -5’ to 14’. The efficacy of the various canards in shifting the center of pressure forward is evaluated. It is found that high aspect ratio canards are the most effective in shifting the center of pressure forward and reducing the static stability. At low angles of attack, inline canards having an aspect ratio of ten shift the center of pressure forward by 2.2 body diameters, relative to the case without canards. In comparison, inline canards having an aspect ratio of two and the same planform area shift the center of pressure forward by 0.7 body diameters only. High aspect ratio, interdigitated canards are less effective than the inline canards by 0.4 body diameters.
Prostaglandins and Prostaglandin Inhibitors in Ischemic Heart Disease (1983)

The evidence for a role of the prostaglandin system in myocardial ischemia and its consequences is still fragmentary. We review the factors that alter the relation between thromboxane A2 and prostacyclin production such that vasoconstriction, platelet aggregation, and the tendency toward thrombus formation are increased. Strategies to prevent platelet aggregation by interfering with the production of thromboxane A2 or by stimulation or administration of prostacyclin are currently under investigation in a number of centers. The ubiquity of the prostaglandin system and our incomplete understanding make careful long-term clinical trials and observations essential if we are to be sure that the net effect of these attempts is beneficial.
Influence of Viscous Deformation at the Contact Point of Primary Particles on Compaction of Alkoxide‐Derived Fine SiO 2 Granules under Ultrahigh Isostatic Pressure (1996)

Viscous deformation and the adhesion force at the contact point between amorphous silica particles under ultrahigh isostatic pressure (up to 1 GPa) are important in the densification of powder compacts. The amount of viscous deformation and the strength of adhesion force have been changed in the present study by altering the calcination temperature and particle diameter, and the new values have been determined successfully using a diametral compression test. The diameter of spherical and monosized alkoxide‐derived silica powders has been controlled within the range of 10–400 nm. Close‐packed granules of these powders have been produced by spray drying. Because of viscous deformation, as‐spray‐dried ultrafine silica powders without calcination could be consolidated into highly dense compacts (&gt;74% of theoretical density) by applying ultrahigh isostatic pressure (1 GPa). Relatively high temperature in the calcined particles (400°C) causes viscous deformation at the contact point to disappear almost completely and clearly increases the adhesion force, because of neck growth that has resulted from viscous sintering. At temperatures &gt;200°C, the green density of the calcined powders decreases to 65% of theoretical density, even under 1 Gpa pressure. The relationship between green density and viscous deformation in silica particles at the point of contact has been analyzed quantitatively by the Hertz and Rumpf model. On the other hand, if relatively low isostatic pressure ( P c &lt; 100 MPa) is applied, the green density and intergranular pore volume depend on the strength of the spray‐dried granules. The relationship between granule strength and neck growth at the contact point with calcination has been estimated quantitatively.
LOCALIZATION OF CEREBROSPINAL FLUID LEAKS BY GADOLINIUM-ENHANCED MAGNETIC RESONANCE CISTERNOGRAPHY (2008)

Gd-enhanced MR cisternography is a sensitive and safe imaging method for detection of CSF leaks in patients with rhinorrhea.
An equation-based battery cycle life model for various battery chemistries (2015)

The evaluation of the cycle life of batteries is an essential task in the assessment of the reliability and cost of battery-operated devices. Several compact cycle life models have been proposed in the literature, that exhibit a general trade-off between generality and accuracy. Some models are based on a compact equation derived from experimental data and try to extract a general relationship between cycle life and the relevant parameters (mostly the depth of discharge), but suffer from poor accuracy. At the other extreme, more accurate models, based on incorporating the aging effect into an equivalent circuit, tend to be focused on a specific device and are seldom applicable to another battery. In this work we propose an equation-based model that tries to overcome the accuracy limits of previous similar models. The model parameters are obtained by fitting the curve based on information reported in datasheets, and can be adapted (with different accuracy levels) to the amount of available information. We applied the model to various commercial batteries for which full information on their cycle life is available. Results show an average estimation error, in terms of the number of cycles, generally smaller than 10%, which is consistent with the typical tolerance provided in the datasheets, and much lower than previous equation-based models.
Propagation of JC Virus in Glia Cells in PML (Progressive Multifocal Leukoencephalopathy (1975)

PML, a rare form of subacute demyelinating disease of the human brain, is caused, in most instances, by JC virus, a new type of papova virus. Light microscopically, the lesions are characterized by hypertrophy of oligodendroglia with intranuclear inclusion and gigantic astroglia with bizarreshaped nuclei. Although viral particles have been found by many investigators, the use of autopsy material has limited the ultrastructural study of changes in the patient. This report concerns some new cytopathological changes based on an electron microscopic study of well fixed biopsy material. Oligodendroglia and astroglia were markedly hypertrophic, but were identified by the presence of abundant cytoplasmic microtubules and filaments, respectively. Intranuclear and intracytoplasmic virions were found in both cell types. The intranuclear virions were the typical round and filamentous forms, with diameters of 40 and 30 mμ, respectively. They were scattered randomly throughout the enlarged nuclei.
Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol (2021)

We examined possible changes in endothelial function during a long agonist in vitro fertilization (IVF) protocol. We measured flow-mediated dilatation (FMD) and FMD percent (FMD%) from the brachial artery and plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-〈). We studied longitudinally three time points in 27 women undergoing a long agonist IVF treatment at Kuopio University Hospital. The first visit was at the beginning of their period (low estradiol). The other two visits were during gonadotrophin-releasing hormone (GnRH) analog downregulation (low estradiol) and at the end of follicle-stimulating hormone (FSH) stimulation (high estradiol). The first visit was used as the reference, and the women served as their own controls. During the stimulation protocol, FMD and FMD% remained. Toward the end of stimulation, hsCRP (P = 0.003), IL-6 (P = 0.04), and TNF-〈 (P = 0.008) concentrations all decreased, while estradiol levels increased (P < 0.001). Correlations between estradiol and proinflammatory factors or FMD were, however, non-significant. The only significant correlation appeared between FMD% and hsCRP at Visit 2 (r = 0.485, P = 0.01). In conclusion, IVF stimulation promoted no change in endothelial function, whereas hsCRP, IL-6, and TNF-〈 decreased. These findings indicate that estrogen may improve the cytokine profile among healthy women undergoing IVF, but this is not reflected in endothelial function.
Framework for the semantic Web: an RDF tutorial (2000)

The current World Wide Web supports mainly human browsing and searching of textual content. This model has become less and less adequate as the mass of available information increases. What is required instead is a model that supports integrated and uniform access to information sources and services as well as intelligent applications for information processing on the Web. Such a model requires standard mechanisms for interchanging data and handling different data semantics. The Resource Description Framework (RDF) is a step in this direction. RDF provides a data model that supports fast integration of data sources by bridging semantic differences. It is often used (and was initially designed) for representing metadata about other Web resources, such as XML files. However, representing metadata about the Web is not different from representing data generally. Thus, RDF can be used as a general framework for data exchange on the Web.
Excavating effective information in different stage of backbone to improve semantic segmentation results (2019)

Abstract To overcome the two difficulties in semantic segmentation task:1) the presence of multi-scale objects, 2) the loss of spatial resolution, a new semantic segmentation model is designed in this paper, which can explore effective information from different stage of backbone. Extensive experiments conducted on two public benchmark datasets have proved the effectiveness of each module, and the new model achieves 73.62% mIoU on Cityscapes test set and 79.88% mIoU on PASCAL VOC 2012 test set.
Test generation for hybrid iterative logic arrays (2002)

The test generation problem for hybrid iterative logic arrays (ILAs) which are constructed from ILAs of different types of cells by interconnecting them along their boundaries to realize a complex combinational function is discussed. The test generation problem for hybrid ILAs is complicated by the presence of different types of cell functions that affect test controllability and observability in different ways. For an array to be testable with a fixed number of test vectors irrespective of its size (C-testable), each of the individual constituent ILAs must satisfy certain rigid conditions that make test generation a difficult task. A graphical model is presented for test computation, and it is shown how this model can be used very effectively to generate efficient tests sets for hybrid ILAs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optical 3D Deformation Measurement Utilizing Non-Planar Surface for Development of "Intelligent Tire"(<Special Issue>Solid Mechanics Indispensable for Automobile Engineering) (2009)

Intelligent tires, also known as smart tires, are equipped with sensors to monitor the strain of the interior surface and the rolling radius of tire, and are expected to improve the reliability of tires and tire control systems such as anti-lock braking systems (ABS). However, the high stiffness of an attached sensor like a strain gauge causes debonding of sensors from tire rubber. In the present study, a novel optical method is used for the concurrent monitoring of in-plane strain and out-of-plane displacement (rolling radius) utilizing the non-planar surface of the monitoring object. The optical method enables noncontact measurement of strain distribution. The in-plane strain and out-of-plane displacement are calculated by using image processing with an image of the interior surface of tire that is taken with a single CCD camera fixed on a wheel rim. This new monitoring system is applied to an aluminum beam and a commercially available radial tire. As a result, the monitoring system provides concurrent measurement, of in-plane strain, out-of-plane displacement and tire pressure, and is shown to be effective as the monitoring system for the intelligent tires.
Effect of Hydrotalcite on Bromine Content in Oil Produced from the Pyrolysis of Acrylonitrile-Butadiene-Styrene Plastics (2015)

In this study, a method is presented to reduce the halogen concentration in the oil produced upon pyrolysis of acrylonitrile-butadiene-styrene (ABS) resins containing brominated flame retardants. More specifically, hydrotalcite was added to a predetermined amount of ABS in a glass reactor, and subjected to pyrolysis at 400 C in nitrogen atmosphere. The bromine content in the product oil, residue, and gas released upon pyrolysis was analyzed. The main components of the product oil following pyrolysis of ABS in the absence of hydrotalcite additive were toluene, ethylbenzene, styrene, 1-bromomethyl-4-methylbenzene, phenol, n-butyl benzene, 1-methoxy-1-methylethyl benzene, and bromine compounds 2-bromophenol, 4-benzyloxy bromobenzene, 2,6 dibromophenol, and 2-bromotoluene. In contrast, the content of bromine in the product oil decreased when hydrotalcite was added to ABS. Moreover, negligible amounts of bromine were detected when the amount of added hydrotalcite was greater than 8 g. The reduced content of bromine in the product oil was attributed to the efficient trapping of bromine in the hydrotalcite matrix (as determined by the content of bromine in the residue).
Zusammenarbeit mit der Berufsberatung für eine von der Eignung ausgehende Lehrlingsvermittlung (1958)

Nur eine Minderheit der beteiligten Firmen bekannte sich zu der Praxis, für die Beurteilung des Geeignetseins von Lehrstellenanwärtern und die darauf sich gründende Lehrlingsvermittlung ausschließlich die regional zuständige Berufsberatungsstelle in Anspruch zu nehmen. Umgekehrt wurde aber von nur ganz wenigen Lehrfirmen die Zusammenarbeit mit der Berufsberatung gänzlich verneint oder gar als wenig erfolgversprechend bezeichnet.
Development of a New Continuous Monitor for Nonvolatile Solute in Ultrapure Water by Atomization (1987)

A new monitoring system has been developed for continuously measuring the concentration of total nonvolatile impurities in ultrapure water. The measuring method is based on the principle of determining the Residue After Evaporation (RAE) of atomized droplets, taking account of the particle deposition loss. The system consists of a water atomizing unit, a droplet evaporating and drying unit, an air diluter, a fine particle counter, etc. For the particle counter, a Condensation Nucleus Counter (CMC) is used; this counter is a mixing type, able to detect particles larger than 0.01 μm. It is verified from both the theoretical analysis and the experimental results that this monitor can rapidly detect very low impurity concentrations by counting the number concentration of aerosol particles.
High-current backside-illuminated InGaAs/InP p-i-n potodiode (2009)

We proposed a high-current backside-illuminated InGaAs/InP p-i-n photodiode (PD) with a non-absorbing drift region, and demonstrated an RF power output of 29.0 dBm at 5 GHz, a 3-dB bandwidth of 7 GHz, and a third order intercept point of 31 dBm at 2 GHz using a 70-μm-diameter PD.
Molecular-level similarity search brings computing to DNA data storage (2021)

As global demand for digital storage capacity grows, storage technologies based on synthetic DNA have emerged as a dense and durable alternative to traditional media. Existing approaches leverage robust error correcting codes and precise molecular mechanisms to reliably retrieve specific files from large databases. Typically, files are retrieved using a pre-specified key, analogous to a filename. However, these approaches lack the ability to perform more complex computations over the stored data, such as similarity search: e.g., finding images that look similar to an image of interest without prior knowledge of their file names. Here we demonstrate a technique for executing similarity search over a DNA-based database of 1.6 million images. Queries are implemented as hybridization probes, and a key step in our approach was to learn an image-to-sequence encoding ensuring that queries preferentially bind to targets representing visually similar images. Experimental results show that our molecular implementation performs comparably to state-of-the-art in silico algorithms for similarity search.