gebhart/patrepeval huggingface dataset:
Vitamin K: Novel molecular mechanisms of action and its roles in osteoporosis (2013)

Vitamin K is a fat-soluble vitamin, which is involved in blood coagulation mediated by maintaining the activity of coagulation factors in the liver. Vitamin K also has extrahepatic actions and has been shown to prevent bone fractures in clinical studies. In addition, epidemiological studies suggest that a lack of vitamin K is associated with several geriatric diseases, including osteoporosis, osteoarthritis, dementia and arteriosclerosis. It has also been shown that vitamin K contributes to the prevention and treatment of some kinds of malignancies. Recently, we discovered a novel role for vitamin K as a ligand of the nuclear receptor, steroid and xenobiotic receptor (SXR), and its murine ortholog, pregnane X receptor (PXR). In addition to its established roles as a cofactor of γ-glutamyl carboxylase (GGCX) in mediating post-transcriptional modifications, vitamin K has a different mode of action mediated by transcriptional regulation of SXR/PXR target genes. Analysis of bone tissue from PXR-deficient mice showed that the bone protective effects of vitamin K are partially mediated by SXR/PXR-dependent signaling. The discoveries of a novel mode of vitamin K action have opened up new possibilities that vitamin K might be useful for prevention or treatment of a variety of diseases that affect the geriatric population.
Multiecho pseudo‐golden angle stack of stars thermometry with high spatial and temporal resolution using k‐space weighted image contrast (2017)

A self-navigated 3D multiecho SOS sequence with dynamic KWIC reconstruction is a promising thermometry method that provides multiple temperature sensitive quantitative values. Magn Reson Med 79:1407-1419, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Cross-GUI Handbook: For Multiplatform User Interface Design (1994)

Design Principles. Human Factors. Presentation. Interaction. Conclusion. Desktop. Desktop and Its Environment. Desktop Metaphor. DesktopObjects. Desktop Managers. Comparison of Desktop Environments. Icon Design. Desktop Trends. Conclusion. Windows. Elements of a Window. Window Controls. Types of Windows. Window Hierarchy. Window Status. Window Behavior. Window Arrangment. Conclusion. Menus. Menu Presentation. Components of a Menu. Types of Menus. Types of Menu Items. Desktop Menus. Application Menus. Object Menus. Conclusion. Controls. Check Box (Check Button). Close Control. Combination Box (Combo Box). Command Button (Push Button). Container. Drop-Down Combination Box. Drop-Down List Box. List Box (Selection List or Scrolling List). Maximize Button. Minimize Button. Multimedia Controls. Notebook. Radio Button (Option Button). Restore Button. Scroll Bar. Size Control. Slider. Spin Box. Split Box. Text Box (Text Field). Toolbar. Value Set. Dialog Boxes. Elements of a Dialog Box. Dialog Box Controls. Dialog Box Behaviors. Common Dialog Boxes. General Design Tips. Dialog Box Trends. Conclusion. Interaction and Feedback. Interaction Model. Interaction Devices and Their Operations. Object-Action Model. Object Types and Classes. Manipulation Principles. Selection. Drag and Drop. Activation. Navigation (Transversal). Data Transfer. Providing Feedback. System Modes. Conclusion. Appendix A: Windowing System Component Terminology. Appendix B: Windowing System Component Graphical Representation. 0201575922t04062001
Evolution of the mammary gland from the innate immune system? (2006)

The mammary gland is a skin gland unique to the class Mammalia. Despite a growing molecular and histological understanding of the development and physiology of the mammary gland, its functional and morphological origins have remained speculative. Numerous theories on the origin of the mammary gland and lactation exist. The purpose of the mammary gland is to provide the newborn with copious amounts of milk, a unique body fluid that has a dual role of nutrition and immunological protection. Interestingly, antimicrobial enzymes, such as xanthine oxidoreductase or lysozyme, are directly involved in the evolution of the nutritional aspect of milk. We outline that xanthine oxidoreductase evolved a dual role in the mammary gland and hence provide new evidence supporting the hypothesis that the nutritional function of the milk evolved subsequent to its protective function. Therefore, we postulate that the mammary gland evolved from the innate immune system. In addition, we suggest that lactation partly evolved as an inflammatory response to tissue damage and infection, and discuss the observation that the two signaling pathways, NF-kB and Jak/Stat, play central roles in inflammation as well as in lactation.
Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step (2007)

Endocannabinoids (eCBs) mediate short- and long-term depression of synaptic strength by retrograde transsynaptic signaling. Previous studies have suggested that an eCB mobilization or release step in the postsynaptic neuron is involved in this retrograde signaling. However, it is not known whether this release process occurs automatically upon eCB synthesis or whether it is regulated by other synaptic factors. To address this issue, we loaded postsynaptic striatal medium spiny neurons (MSNs) with the eCBs anandamide (AEA) or 2-arachidonoylglycerol and determined the conditions necessary for presynaptic inhibition. We found that presynaptic depression of glutamatergic excitatory postsynaptic currents (EPSCs) and GABAergic inhibitory postsynaptic currents (IPSCs) induced by postsynaptic eCB loading required a certain level of afferent activation that varied between the different synaptic types. Synaptic depression at excitatory synapses was temperature-dependent and blocked by the eCB membrane transport blockers, VDM11 and UCM707, but did not require activation of metabotropic glutamate receptors, l-calcium channels, nitric oxide, voltage-activated Na(+) channels, or intracellular calcium. Application of the CB(1)R antagonist, AM251, after depression was established, reversed the decrease in EPSC, but not in IPSC, amplitude. Direct activation of the CB(1) receptor by WIN 55,212-2 initiated synaptic depression that was independent of afferent stimulation. These findings indicate that retrograde eCB signaling requires a postsynaptic release step involving a transporter or carrier that is activated by afferent stimulation/synaptic activation.
User Interaction and Authoring of 3D Sound Scenes in the Carrouso EU project (2003)

cote interne IRCAM: Vaananen03a
Supplemental Figure 2 from CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110 (2023)

&lt;p&gt;Supplemental Fig. S2. Overexpression of wild-type CP110, but not phosphorylation-sites mutated CP110 in LKR13 murine lung cancer cells that are driven by KRAS rescued anaphase catastrophe and reduced apoptosis induced by pharmacological CDK2 inhibition after seliciclib treatment. LKR13 cells overexpressing wild-type CP110 species or an empty vector, a phosphorylation-sites mutant-CP110 species (MUT-CP110) or an empty vector (Vector) were treated with indicated dosages of seliciclib. After 24 hours treatment, LKR13 cells were (A) scored for multipolar anaphase and (B) analyzed for apoptosis, as detected by Annexin V:FITC and 7-aminoactinomycin D (7-AAD) staining.&lt;/p&gt;
Si Schottky sampling bridge circuits for demultiplexer (2003)

In this paper, we present a Si Schottky diode sampling bridge circuit for demultiplexer using flip-chip technology on alumina substrate(Al/sub 2/O/sub 3/). A Si Schottky diode is modeled using the Root diode model up to 40 GHz. Flip-chip interconnections are simulated using 3 dimensional electromagnetic simulator, Ansoft HFSS. Using those models, the sampling bridge circuits are designed and experimentally investigated. A sampling phenomena is confirmed observing the measurement waveform.
Effective Electron Temperature Measurement Using Time-Resolved Anti-Stokes Photoluminescence (2020)

Anti-Stokes photoluminescence of metal nanoparticles, in which emitted photons have a higher energy than the incident photons, is an indicator of the temperature prevalent within a nanoparticle. Previous work has shown how to extract the temperature from a gold nanoparticle under continuous-wave monochromatic illumination. We extend the technique to pulsed illumination and introduce pump-probe anti-Stokes spectroscopy. This new technique enables us not only to measure an effective electron temperature in a gold nanoparticle (∼10<sup>3</sup> K under our conditions), but also to measure ultrafast dynamics of a pulse-excited electron population, through its effect on the photoluminescence, with subpicosecond time resolution. We measure the heating and cooling, all within picoseconds, of the electrons and find that, with our subpicosecond pulses, the highest apparent temperature is reached 0.6 ps before the maximum change in magnitude of the extinction signal.
Activated Platelet‐Targeted IR780 Immunoliposomes for Photothermal Thrombolysis (2022)

Abstract Acute thrombosis is a leading cause of mortality and morbidity worldwide. Pharmacological thrombolysis relies on plasminogen activators (PAs), which are associated with major side effects including potentially fatal bleeding. Alternative therapeutic options that do not rely on PAs are urgently required. Here, the efficacy of targeted photothermal therapy is evaluated for thrombolysis using liposomes loaded with IR780 dye, which release heat upon near‐infrared (NIR) irradiation. Liposomes targeted to activated platelets—one of the main components of thrombi—accumulate preferentially in thrombi both in vitro and in vivo compared to non‐targeted controls. In a mouse model of thrombosis, targeted IR780 immunoliposomes (Tar‐IR‐L) produce ≈12 °C average local temperature increase upon NIR irradiation (5 min, 1 W cm −2 ). This causes a significant reduction in clot area compared to controls treated with non‐targeted liposomes or phosphate‐buffered saline, which only increase local temperature slightly (6 and 3 °C) when irradiated. Co‐loading a low‐dose single chain urokinase plasminogen activator (scuPA) to targeted IR780 liposomes (Tar‐scuPA‐IR‐L) does not result in a superior thrombolytic effect, which indicates that photothermal therapy alone may allow thrombolysis without the need for fibrinolytic drugs. This approach may prevent potential bleeding complications, promising a safer alternative to current pharmacological approaches.
An OGMS-based Model for Clinical Information (MCI). (2013)

More and more detailed, complex and new data about the patient’s health status as well as about medical knowledge become available. The synopsis of this heterogeneous, patient-customized information is crucial for physicians to make the correct diagnosis. The problem however is that these heterogeneous data are not semantically integrated. As a result most of the available data and knowledge is often not used in their full strength in clinical decisions. Semantic integration requires annotation of clinical data with concepts or codes from established domain ontologies covering medical and clinical knowledge such as the Foundational Model of Anatomy (FMA), SNOMED CT or the International Classification of Diseases (ICD). Further, an ontologically well founded information model structuring the references to these ontologies is needed. Today’s models of clinical information like the HL7 Reference Information Model however lack a well defined ontological foundation. The resulting ambiguities make it difficult to map clinical data to their schema and to reuse clinical data stored in them. In this paper we present initial work on a Model for Clinical Information (MCI) based on the Ontology of General Medical Science (OGMS) and other OBO ontologies. MCI focuses on metainformation and high-level concepts with the aim to provide a basis for data integration and knowledge exploration. 1
In vitroelucidation of suppression effects of composts to soil-borne pathogenPhytophthora nicotianaeon pepper plants using 16S amplicon sequencing and metaproteomics (2018)

Abstract Compost production is a critical component of organic waste management. One of the most important properties of compost is its ability to suppress soil-borne pathogens such as Phytophthora nicotianae in pepper plants. Both the physico-chemical and biological properties of composts can be responsible for the suppression of pathogens, although biological properties are the main driver. In this study, we analyzed composts with various levels of suppressiveness against P. nicotianae . We analyzed both physico-chemical properties like pH and electrical conductivity and biological properties like microbial activity, amplicon sequencing and metaproteomics. We believed that the link between community structures and proteins could provide deep insights into the mechanism of compost suppressiveness. Our results indicate that there are differences between suppressive and non-suppressive composts at the phylogenetic level (sequencing) and at the functional level (based on analysis of the cluster of orthologous groups, COGs). The proteins identified were assigned to the carbohydrate process, cell wall structure and inorganic ion transport and metabolism. Proteobacteria could also be new indicators of P. nicotianae suppression.
Examining the weekend effect across ICU performance metrics (2019)

This work reinforces the importance of accounting for differences in clinical factors as well as patient cohorts in studies investigating the weekend effect.
Reducing Hospital-Acquired Pressure Ulcer Prevalence Through a Focused Prevention Program (2008)

A pressure ulcer prevention program has been developed, which has shown a trend toward improved patient outcomes with a resultant cost savings.
Improved recovery of fatty acid through direct transesterification without prior extraction or purification. (1984)

Methods currently in use for the quantitative measurement of fatty acids by gas-liquid chromatography after transesterification are usually lengthy and cumbersome. The technique described is a one-step reaction that is carried out in the same tube and bypasses all the extraction and purification steps. Recoveries of fatty acid and triglyceride standards (C6:0 to C24:1) were better than 96%. When the direct transesterification method was compared to the Folch extraction procedure, increases of fatty acid concentration of 11.4% and 15.8% were observed in human milk and adipose tissue, respectively. The method appears to be particularly advantageous for the recovery of the highly volatile medium chain triglycerides and there is no need to add an antioxidant to protect unsaturated lipids.
Altered Glycosylation in Tumours Focused to Cancer Diagnosis (2008)

The lack of specific and sensitive tumour markers for early detection of cancer is driving a search for new approaches that could identify biomarkers. Markers are needed to alert clinicians at the early stages of tumourogenesis, before the cancer has metastasized, when the therapeutic drugs are more effective. Most tumour markers currently used in clinics are serum glycoproteins, frequently highly glycosylated mucins. Typically, the disease marker is the protein and not the glycan moiety of the corresponding glycoprotein or mucin. The increasing knowledge of the role of glycans in cancer suggests that further studies may assist both in determining their role in every step of tumour progression, and in the design of new therapeutic and diagnosic approaches. Detection of the altered glycans in serum tumour glycoproteins could be a way to achieve specificity in tumour detection. In this review, we focus on the glycan changes of two serum glycoproteins, prostate specific antigen--currently used as a tumour marker of prostate cancer--and human pancreatic ribonuclease in pancreatic adenocarcinoma. The detection of glycan changes, associated with subsets of glycoforms in serum glycoproteins that are specific to the tumour situation, could be the basis for developing more specific biomarkers.
Differential Induction of Cytochrome P450-Mediated Triasulfuron Metabolism by Naphthalic Anhydride and Triasulfuron (1995)

Cytochrome P450 monooxygenases play paramount roles in the detoxification of herbicides as well as in the synthesis of lignins, flavonoids, and phenolic acids. Biochemical analysis of triasulfuron metabolism in maize (Zea mays) seedlings has demonstrated that the P450(s) responsible for detoxification of this herbicide is induced by naphthalic anhydride (NA), a plant safener, and by triasulfuron, the herbicide itself. Induction studies conducted with seedlings of different ages suggest that two separate response pathways modulate this P-450 activity. Induction by NA is independent of the developmental age of the seedlings up to 6.5 d; induction by triasulfuron is tightly modulated with respect to developmental age in that triasulfuron metabolism can be induced by triasulfuron in young (2.5 d) but not older (6.5 d) seedlings. Induction by NA administered in combination with triasulfuron synergistically enhances triasulfuron metabolism in younger seedlings to levels substantially above that obtained with either herbicide or safener treatment alone. In older seedlings, NA plus triasulfuron treatment induces triasulfuron metabolism to only the level of NA treatment alone, indicating again that the induction cascade responding to triasulfuron is nonfunctional in later development. MnCl2 studies indicate that the triasulfuron insensitivity of older seedlings does not result from a general limitation in the inducibility of this P-450 detoxification system but rather from specific limitations in the triasulfuron-response pathway.
A common hard-failure mechanism in GaN HEMTs in accelerated switching and single-pulse short-circuit tests (2023)

We report that the hard-failure mechanism observed in single-pulse short-circuit (SPSC) stress tests can also be observed in repetitive hard-switching stress tests as Dynamic High Temperature Operating Lifetime (D-HTOL) and Switching Accelerated Life Test (SALT). This is independent of the device and technology concept in lateral power GaN HEMTs. Thus., the failure physics of two different failure modes can be related to a common model. Our findings enable a better understanding of the different primary and secondary degradation modes and their implication on application lifetime models of different GaN technology concepts.
Real-Time Frequency Response Estimation from Flight Data (2016)

A nonparametric method for estimating frequency responses in real-time using a method based on recursive least squares in the time domain was developed and studied. The proposed method uses sinusoidal functions at selected frequencies known to be contained in the input in conjunction with recursive least squares to rapidly estimate Fourier series coefficients for input and output time series, and thereby estimate frequency responses. Practical problems that arise when applying the discrete Fourier transform in recursive form were identified using simple examples. A general expression for accurate real-time calculation of the covariance matrix for recursive least squares parameter estimation was developed and used to calculate valid uncertainty bounds for real-time frequency response estimates. Simulation data generated with optimized multi-sine inputs were used to investigate the accuracy of the proposed method for real-time frequency response estimation, and to validate the calculated error bounds. The approach was also applied in real-time to flight data from a subscale jet transport aircraft. Comparisons of real-time frequency response estimates and error bounds with results from conventional post-flight batch analysis showed that results from the real-time method were in statistical agreement with post-flight batch estimates, with valid error bounds that properly indicated the quality of the real-time frequency response estimates.
On the Behavioral Economics of Crime (2012)

Abstract This paper examines the implications of the brain sciences’ mechanistic model of human behavior for our understanding of crime. The standard rational-choice crime model is refined by a behavioral approach, which proposes a decision model comprising cognitive and emotional decision systems. According to the behavioral approach, a criminal is not irrational but rather ‘ecologically rational,’ outfitted with evolutionarily conserved decision modules adapted for survival in the human ancestral environment. Several important cognitive as well as emotional factors for criminal behavior are discussed and formalized, using tax evasion as a running example. The behavioral crime model leads to new perspectives on criminal policy-making.
Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer (2017)

[This corrects the article DOI: 10.1371/journal.pone.0133219.].
Development of Compact Readout Device for Neural Observation System using Fluorescence Imaging and Fast-scan Cyclic Voltammetry (2022)

A readout device for a dual-functional neural observation system is presented. The authors separately developed the reading operation of an implantable CMOS image sensor and a setup for fast-scan cyclic voltammetry and implemented them together in a microcontroller-based device. The developed imaging readout device with a size of [Formula: see text] can reach the highest reading rate of 160 fps with a 120×268 pixel image sensor. The voltammetry function was verified through an experiment using commercial carbon fiber electrodes in phosphate-buffered saline. When the imaging is sequentially operated with 400 V/s-scan rate voltammetry from -0.4 to 1.3 V, the system can operate at up to 60 fps. With this system, calcium imaging and dopamine recording in a freely behaving mouse can be achieved together in a simpler manner. This study aims to be the basis for the development of an implantable multi-functional sensor.