gebhart/patrepeval huggingface dataset:
Abstract 2113: Arsenic hexoxide inhibits NF-κB activity through, at least in part, suppression of IκBα phosphorylation in MCF-7 human breast cancer cells. (2013)

Abstract Arsenic hexoxide (As4O6) has been used in Korean folk remedy for the treatment of cancer since the late 1980’s. Evidence suggests that the anti-cancer effects of As4O6 are different from those of As2O3. Nuclear factor-κB (NF-κB) is a well-known transcription factor involved in cell proliferation, invasion and metastasis. Here, we investigated the effects of As4O6 on NF-κB activity, NF-κB-regulated gene expressions, and NF-κB-mediated cellular responses. As4O6 suppressed NF-κB activation induced by TNF-α, and the some of the downstream NF-κB-regulated proteins involved in caner proliferation, metastasis and anti-apoptosis. As4O6 also suppressed IκB phosphorylation in a time-dependent manner, suggesting the suppression of NF-κB results from at least in part by inhibiting IκB degradation. We also confirmed the anti-NF-κB activity of As4O6 with synergism with TNF-α at the molecular levels. This study demonstrates that As4O6 inhibits NF-κB activation and NF-κB regulated proteins at least in part through the inhibition of IκB phosphorylation. [This study was supported by a grant from the National R&amp;D Program for Cancer Control, Ministry for Health, Welfare &amp; Family Affairs, Republic of Korea. (0820050), and National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (20120002631).] Keywords: Arsenic hexoxide, Nuclear factor-κB, IκB, cancer Citation Format: Won Sup Lee, Min Jeong Kim, Ji-Hyun Jung, Jeong Won Yun, Jing Nan Lu, Sang mi Yi, Hye Jung Kim, Seong-Hwan Chang, GonSup Kim, Soon Chan Hong, Woo song Hwa. Arsenic hexoxide inhibits NF-κB activity through, at least in part, suppression of IκBα phosphorylation in MCF-7 human breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2113. doi:10.1158/1538-7445.AM2013-2113
Targeting Activated Platelets: A Unique and Potentially Universal Approach for Cancer Imaging (2017)

<b>Rationale</b> The early detection of primary tumours and metastatic disease is vital for successful therapy and is contingent upon highly specific molecular markers and sensitive, non-invasive imaging techniques. We hypothesized that the accumulation of activated platelets within tumours is a general phenomenon and thus represents a novel means for the molecular imaging of cancer. Here we investigate a unique single chain antibody (scFv), which specifically targets activated platelets, as a novel biotechnological tool for molecular imaging of cancer. <b>Methods</b> The scFv<sub>GPIIb/IIIa</sub>, which binds specifically to the activated form of the platelet integrin receptor GPIIb/IIIa present on activated platelets, was conjugated to either Cy7, <sup>64</sup>Cu or ultrasound-enhancing microbubbles. Using the Cy7 labelled scFv<sub>GPIIb/IIIa</sub>, fluorescence imaging was performed in mice bearing four different human tumour xenograft models; SKBr3, MDA-MB-231, Ramos and HT-1080 cells. Molecular imaging via PET and ultrasound was performed using the scFv<sub>GPIIb/IIIa</sub>-<sup>64</sup>Cu and scFv<sub>GPIIb/IIIa</sub>-microbubbles, respectively, to further confirm specific targeting of scFv<sub>GPIIb/IIIa</sub> to activated platelets in the tumour stroma. <b>Results</b> Using scFv<sub>GPIIb/IIIa</sub> we successfully showed specific targeting of activated platelets within the microenvironment of human tumour xenografts models via three different molecular imaging modalities. The presence of platelets within the tumour microenvironment, and as such their relevance as a molecular target epitope in cancer was further confirmed via immunofluorescence of human tumour sections of various cancer types, thus validating the translational importance of our novel approach to human disease. <b>Conclusion</b> Our study provides proof of concept for imaging and localization of tumours by molecular targeting activated platelets. We illustrate the utility of a unique scFv as a versatile biotechnological tool which can be conjugated to various contrast agents for molecular imaging of cancer using three different imaging modalities. These findings warrant further development of this activated platelet specific scFv<sub>GPIIb/IIIa</sub>, potentially as a universal marker for cancer diagnosis and ultimately for drug delivery in an innovative theranostic approach.
An overview of abuse-deterrent opioids and recommendations for practical patient care (2018)

Despite advances in the treatment of severe intractable pain, opioids remain a critical and appropriate component of treatment. However, abuse, misuse, and diversion of prescription opioids are significant public health concerns. Opioid abuse-deterrent formulations (ADFs) are one component of an opioid risk management plan to manage patient's pain relief and quality of life while offering some protection against potentially harmful consequences of opioids from misuse and abuse. Opioid ADFs are designed to make manipulation more difficult and administration via non-oral routes less appealing. There are currently nine extended-release and one immediate-release opioid pain medications with US Food and Drug Administration-approved ADF labeling. All use physical/chemical barriers or agonist/antagonist combinations to deter manipulation and abuse. Evidence suggests that opioid ADFs decrease rates of abuse and diversion of opioids in the USA; however, some opioid ADFs are not yet commercially available or have not been on the market long enough to undergo post-marketing data analyses. Opioid ADFs along with the use of prescription drug monitoring programs, clinical assessment tools, toxicology testing, and co-prescribing of naloxone are all tools that can be used to reduce opioid abuse. Patient education on the risks of abuse and diversion is vital and includes a discussion of appropriate use of medication and proper storage. Physician assistants and nurse practitioners are on the "front lines" in battling opioid abuse and serve a key role in recognizing and mitigating the risks of prescription opioid diversion, abuse, and misuse (intentional and unintentional) and in identifying patients at risk for abuse while still providing pain relief to patients.
Task‐related changes in sensorimotor integration influence the common synaptic input to motor neurones (2014)

Alteration of visual feedback influences nearly the entire frequency spectrum of common input to motor neurones, as well the gain of afferent feedback. We speculate that task-related modulation of afferent feedback could be the origin of many of the observed changes in the neural drive to muscles.
In 2018 “Spring Is the Time of Plans and Projects” (2018)

Editor of Oncology Rehabilitation and Emeriti Professor, Physical Therapy Department, University of Michigan-Flint, Flint, MI Correspondence: Lucinda (Cindy) Pfalzer, PT, PhD, FACSM, FAPTA, Physical Therapy Department, University of Michigan-Flint, 2157 WSW Bldg, Flint, MI 48502 ([email protected]). The author declares no conflicts of interest.
Nanostructured Ternary Electrodes for Energy‐Storage Applications (2012)

Abstract A three‐component, flexible electrode is developed for supercapacitors over graphitized carbon fabric, utilizing γ‐MnO 2 nanoflowers anchored onto carbon nanotubes (γ‐MnO 2 /CNT) as spacers for graphene nanosheets (GNs). The three‐component, composite electrode doubles the specific capacitance with respect to GN‐only electrodes, giving the highest‐reported specific capacitance (308 F g −1 ) for symmetric supercapacitors containing MnO 2 and GNs using a two‐electrode configuration, at a scan rate of 20 mV s −1 . A maximum energy density of 43 W h kg −1 is obtained for our symmetric supercapacitors at a constant discharge‐current density of 2.5 A g −1 using GN–(γ‐MnO 2 /CNT)‐nanocomposite electrodes. The fabricated supercapacitor device exhibits an excellent cycle life by retaining ≈90% of the initial specific capacitance after 5000 cycles.
A CMOS IF Variable Gain Amplifier with Exponential Gain Control (2005)

An intermediate frequency (IF) variable gain amplifier (VGA) with exponential gain control for a radio receiver is fabricated in 0.25-m CMOS technology. The techniques to improve the bandwidth and to reduce temperature dependence of gain are described. The complete VGA is composed of two stages of linearized transconductance VGA and three stages of fixed gain amplifier (FGA). The complete VGA provides a continuous 10 dB to 76.5 dB gain control range, an IIP3 of -11.5 dBm and an NF of 15 dB at 40 MHz. key
Angle sensitive pixels in CMOS for lensless 3D imaging (2009)

We present a pixel-scale CMOS sensor for near-field, lensless 3D imaging. This angle-sensitive pixel (ASP) uses local, stacked diffraction gratings over a photodiode to discriminate the incident angle of incoming light. The ASPs, measuring 20 mum wide and 40 mum long, have been built in an unmodified 130 nm CMOS process. Metal wiring layers provide the required gratings, while intrinsic pn-junctions act as photodiodes. We present operating principles and design considerations of the ASP, as well as results demonstrating desired angle sensitivity. Arrays of ASPs enable lensless microscale imaging that reconstructs the 3-dimensional structure of light sources.
Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey (2016)

1. The number of developed therapeutic monoclonal antibodies (mAbs) has increased in this decade. This study aims to predict their pharmacokinetic profiles after intravenous (iv) injection using only the data taken after subcutaneous (sc) injection in cynomolgus monkey. 2. Two-compartment model parameters, Q, V<sub>c</sub> and V<sub>p</sub>, were collected from the published data after iv injection in cynomolgus monkey for 21 mAbs (Group A). Bioavailability after sc injection (F), CL and serum/plasma concentration after iv injection of other published 19 mAbs (Group B) were predicted using the estimated geometric means of Q, V<sub>c</sub> and V<sub>p</sub> in Group A and the serum/plasma concentration after sc injection in Group B. 3. F and CL of 18 out of 19 mAbs in Group B were successfully predicted within 30% difference of observed value. Moreover, most of the observed serum/plasma concentrations after iv injection of mAbs in Group B were successfully predicted within 2-fold difference. Our approach suggests that iv injection might not be required to evaluate absorption of mAbs after sc injection in cynomolgus monkey. Therefore, our approach might reduce the time and cost of drug development, reduce the burden on resources, and also contribute to animal welfare.
The effect of sentence repetition on speech intelligibility in noise (2006)

The effect of sentence repetition on speech intelligibility in noise was investigated. The benefits of repetition on word intelligibility under continuous and fluctuation noise conditions and the effects of noise conditions on the parameters of the performance-intelligibility (PI) function for sentence spoken once or twice, was examined. Eighteen French-speaking subjects aged between 20 and 30 years with normal hearing were presented lists of 20 sentences from the Canadian French HINT test under three different noise such as continuous speech spectrum noise, and modulated speech-spectrum noise. The subjects were asked twice to repeat heard word under different noise conditions and a score was marked for each response. It was observed that repetition improves the SRT from 2.0 to 5.4 dB and increases the slope of PI function. Result shows that the speech intelligibility is highly pronounced in modulated noise and least in continuous noise.
Guest Loading and Multiple Phases in Single Crystals of the van der Waals Host p-tert-Butylcalix[4]arene (2008)

We have followed the loading of xenon into the low density form of a van der Waals solid host, p- tert-butylcalix[4]arene (tBC), with solid-state NMR and X-ray diffraction (XRD), techniques sensitive to local and long-range order, respectively. Even though there was little change in the unit cell parameters, 13C and 129Xe solid-state NMR spectra indicate that significant structural changes occur in local order even at low levels of loading. In particular, 129Xe double quantum experiments, which probe distance-dependent 129Xe− 129Xe dipolar interactions, reveal that the closest Xe−Xe distances increase with Xe loading into the tBC host, suggesting that the tBC undergoes structural rearrangements as it absorbs Xe. Indeed, in light of the solid-state NMR results, a re-examination of partially loaded single crystals by XRD showed that up to a loading level (Xe/tBC ratio) of 0.25, the structure was closely related to that of the empty form with the typical calixarene bilayer structure; however, at higher loading (0.5), the structure is substantially different with a constricted zigzag channel for Xe. In the latter structure, alternate bilayers are distinct because of different molecular orientations and much enhanced thermal parameters. What is remarkable is that the changes described take place with the different structural motifs apparently coexisting in the same single crystal. These different structures have almost identical unit cell parameters; however, the structures are quite different, and the phase transitions are more easily followed with NMR spectroscopy than with diffraction. The fact that ordered domains are always present suggests that cooperative dynamics play an important role, with the experimental results giving snapshots of the loading process at different stages.
Intensive Salvage Therapy With High-Dose Chemotherapy for Patients With Advanced Hodgkin’s Disease in Relapse or Failure After Initial Chemotherapy: Results of the Groupe d’Études des Lymphomes de l’Adulte H89 Trial (2002)

PURPOSE: To evaluate prospectively the feasibility and efficacy of early intensive therapy, including intensified cytoreductive chemotherapy (CT) and high-dose CT (HDCT) followed by autologous stem-cell transplantation (ASCT), in patients with advanced Hodgkin’s disease (HD) who failed to respond completely or relapsed after initial treatment. PATIENTS AND METHODS: Among 533 eligible patients with newly diagnosed stage IIIB-IV HD enrolled in the H89 trial, all 157 patients with induction failure (IF) (n = 67), partial response (PR) of less than 75% (n = 22), or relapse (n = 68) were included in this study. Planned salvage therapy included mitoguazone, ifosfamide, vinorelbine, and etoposide monthly for two to three cycles followed by high-dose carmustine, etoposide, cytarabine, and melphalan with ASCT. RESULTS: With a median follow-up of 50 months, the 5-year survival estimates were 30%, 72%, and 76% for the IF, PR, and relapse groups, respectively (P = .0001), 71% for the 101 patients given HDCT, and 32% for the 48 patients treated without HDCT (P = .0001). Multivariate analysis using time-dependent Cox model indicated that B symptoms at progression, salvage without HDCT, and chemoresistant disease before HDCT were significantly associated with shorter overall survival. CONCLUSION: Early intensive therapy improves the outcomes of patients with advanced HD who failed to respond completely to initial treatment and those who relapsed with adverse prognostic factors. However, for patients with IF and chemoresistant disease, this approach remains unsatisfactory.
Photo-Mediated Decarboxylative Giese-Type Reaction Using Organic Pyrimidopteridine Photoredox Catalysts (2020)

The decarboxylative Giese-type reaction offers a versatile methodology for the radical alkylation of electron-deficient alkenes. Photo-mediated variants often require a pre-activation of carboxylic acids and/or employment of costly transition-metal photocatalysts. Herein, we present a metal-free photocatalyzed decarboxylative Giese-type addition to electron-deficient alkenes using pyrimidopteridine <i>N</i>-oxides as organic photoredox-active catalysts. This protocol comprises mono-, di-, and trisubstituted aliphatic, α-amino, and α-oxy acids as well as a variety of electron-deficient alkenes. Moreover, post-synthetic derivatization and applications are presented.
Optimality and Stability Study of Timing-Driven Placement Algorithms (2003)

This work studies the optimality and stability of timing-driven placement algorithms. The contributions of this work include two parts: 1) We develop an algorithm for generating synthetic examples with known optimal delay for timing driven placement (T-PEKO). The examples generated by our algorithm can closely match the characteristics of real circuits. 2) Using these synthetic examples with known optimal solutions, we studied the optimality of several timing-driven placement algorithms for FPGAs by comparing their solutions with the optimal solutions, and their stability by varying the number of longest paths in the examples. Our study shows that with a single longest path, the delay produced by these algorithms is from 10% to 18% longer than the optima on the average, and from 34% to 53% longer in the worst case. Furthermore, their solution quality deteriorates as the number of longest paths increases. For examples with more than 5 longest paths, their delay is from 23% to 35% longer than the optima on the average, and is from 41% to 48% longer in the worst case.
Coordinated path following control of multiple wheeled robots using linearization techniques (2006)

Abstract The paper addresses the problem of steering a fleet of wheeled robots along a set of given spatial paths, while keeping a desired inter-vehicle formation pattern. This problem arises for example when multiple vehicles are required to scan a given area in cooperation. In a possible mission scenario, one of the vehicles acts a leader and follows a path accurately, while the other vehicles follow paths that are naturally determined by the formation pattern imposed. The paper solves this and other related problems using a simple algorithm that builds on linearization techniques and gain scheduling control theory. Using this set-up, path following (in space) and inter-vehicle coordination (in time) are almost decoupled. Path following for each vehicle amounts to reducing a conveniently defined generalized error vector to zero. Vehicle coordination is achieved by adjusting the speed of each of the vehicles along its path, according to information on the position of all or some of the other vehicles. No other information is exchanged among the robots. The set-up adopted allows for a simple analysis of the resulting coordinated path following control system. The paper describes the structure of the coordination system proposed and addresses challenging problems of robustness with respect to certain types of vehicle failures. Keywords: Coordinated motion controlPath followingTrimming trajectoriesLinearizationGain schedulingWheeled robots Acknowledgement This work was supported by the Portuguese FCT POSI programme under framework QCA III. The first author benefited from a PhD grant from the Foundation for Science and Technology (FCT), Portugal.
Microprocessor-Based Testing Increases Power Plant Availability (1986)

Commercial nuclear power plants need equipment that increases plant availability, reduces test time and is both self-diagnostic and user-friendly. Westinghouse's Process Protection Upgrade System, called Eagle 21™, is a functional replacement for existing analog process protection equipment used to monitor nuclear power stations and to initiate the actuation of the reactor trip and engineering safeguards systems. Periodic testing of this protection equipment is required by industry regulations, and the advent of microprocessor systems has made it possible for plant test personnel to do this required testing in a short time, with great precision, and with few or no errors. The architecture of the testing system is described and the major benefits are highlighted.
A combined additive layer manufacturing / indirect replication method to prototype 3D vascular-like structures of soft tissue and endocrine organs (2012)

We describe an innovative methodology combining Additive Layer Manufacturing (ALM) and indirect replication to reconstruct reticular-like, three-dimensional (3D) structures mimicking the vascular network of soft tissue and endocrine organs. Using a fractal-like algorithm capable of modelling the intraparenchymal vascular distribution of these viscera, single intraglandular branches of the human thyroid arteries were prototyped with synthetic resin, based on the algorithmic standard to layer (STL) output and ALM techniques. Satisfactory dimensional accuracy was obtained for these models, which were used as masters to evaluate protocols for their indirect replication, through both single and double procedures. Additional studies were conducted using casts of the human kidney arteries, obtained by injection / corrosion of the isolated organ. Satisfactory 3D reproduction of the external morphology of the kidney vessels was achieved. We conclude that our approach has the potential to develop up to the reconstruction with biomaterials of an entire, intraparenchymal vascular tree of soft tissue and endocrine organs.
Electrostatic artificial muscle: compact, high-power linear actuators with multiple-layer structures (2002)

Two types of compact, high-power, electrostatically driven actuators with multiple-layer structure, electrostatic artificial muscles, are developed. The actuators have 40 or 50 pairs of sheets interleaved together and enclosed in ready-to-use packages filled with a dielectric liquid. Sliding forces are generated on the surface of each film and are combined into a net force at the bundled edges of the sheets. The first type, a pulse-drive induction artificial muscle, which utilizes induced charges on highly resistive films, generated 8 N propulsive force and 0.5 W mechanical power with 110 g its own mass, The second type, ac-drive variable capacitance artificial muscle that weighs 3.6 kg produced huge output, 310 N, 19 W. These actuators will be used in wide range of application fields scaling from micro manipulators to massive mobile robots.
Asymmetric Flux Pinning in a Regular Array of Magnetic Dipoles (1998)

The effect of a regular array of magnetic dipoles embedded in a superconducting film was investigated. A large asymmetry in critical currents was found between when the magnetic dipoles are aligned and antialigned with respect to an externally applied magnetic field. Enhanced pinning effects were observed when the flux lattice and the dipole lattice were commensurate. The data are used to infer pinning mechanisms, strengths, and sites.
Detecting single ORAI1 proteins within the plasma membrane reveals higher-order channel complexes (2019)

ORAI1 proteins form highly selective Ca<sup>2+</sup> channels in the plasma membrane. Crystallographic data point towards a hexameric stoichiometry of ORAI1 channels, whereas optical methods postulated ORAI1 channels to reside as dimers at rest, and other data suggests that they have a tetrameric configuration. Here, liquid-phase scanning transmission electron microscopy (STEM) and quantum dot (QD) labeling was utilized to study the conformation of ORAI1 proteins at rest. To address the question of whether ORAI1 was present as a dimer, experiments were designed using single ORAI1 monomers and covalently linked ORAI1 dimers with either one or two label-binding positions. The microscopic data was statistically analyzed via the pair correlation function. Label pairs were found in all cases, even for concatenated dimers with one label-binding position, which is only possible if a significant fraction of ORAI1 was assembled in larger order oligomers than dimers, binding at least two QDs. This interpretation of the data was consistent with Blue Native PAGE analysis showing that ORAI1 is mainly present as a complex of an apparent molecular mass larger than that calculated for a dimer.