gebhart/patrepeval huggingface dataset:
Identification of KIF11 as a Novel Target in Meningioma (2019)

Kinesins play an important role in many physiological functions including intracellular vesicle transport and mitosis. The emerging role of kinesins in different cancers led us to investigate the expression and functional role of kinesins in meningioma. Therefore, we re-analyzed our previous microarray dataset of benign, atypical, and anaplastic meningiomas (<i>n</i> = 62) and got evidence for differential expression of five kinesins (KIFC1, KIF4A, KIF11, KIF14 and KIF20A). Further validation in an extended study sample (<i>n</i> = 208) revealed a significant upregulation of these genes in WHO°I to °III meningiomas (WHO°I <i>n</i> = 61, WHO°II <i>n</i> = 88, and WHO°III <i>n</i> = 59), which was most pronounced in clinically more aggressive tumors of the same WHO grade. Immunohistochemical staining confirmed a WHO grade-associated upregulated protein expression in meningioma tissues. Furthermore, high mRNA expression levels of KIFC1, KIF11, KIF14 and KIF20A were associated with shorter progression-free survival. On a functional level, knockdown of kinesins in Ben-Men-1 cells and in the newly established anaplastic meningioma cell line NCH93 resulted in a significantly inhibited tumor cell proliferation upon siRNA-mediated downregulation of KIF11 in both cell lines by up to 95% and 71%, respectively. Taken together, in this study we were able to identify the prognostic and functional role of several kinesin family members of which KIF11 exhibits the most promising properties as a novel prognostic marker and therapeutic target, which may offer new treatment options for aggressive meningiomas.
Pressure Dependence of Cymbal Transducers (2007)

The hydrostatic pressure limit that a receiver can withstand without failure is of major importance in underwater sonar systems. In this paper, the hydrostatic pressure tolerance and sensitivity of cymbal receivers were investigated. The failure mode in cymbal transducers under hydrostatic pressure is described. Effects of cavity geometry and material selection on hydrostatic piezoelectric coefficients and pressure limits were evaluated using both experimental data and finite-element analysis (FEA). It was found that cavity depth has a very strong effect on the stability of underwater sensitivity and pressure tolerance of these devices. Cymbals made with soft piezoelectric transducers (PZTs) possess higher figures of merit and better pressure tolerance than those made with hard PZTs. Alternatively, the cymbal sensitivity and pressure tolerance can be improved by changing the cap material.
FRFC: Fast Table Building Algorithm for Recursive Flow Classification (2010)

Policy lookup is a very essential function in packet forwarding and network security. As it is becoming a main cause of bottleneck in many network systems, this letter introduces a new policy lookup algorithm called FRFC (Fast table building for Recursive Flow Classification). Although it is based on RFC which shows the best policy lookup speed but the worst policy table update speed, it achieves high performance in table update as well as policy lookup. FRFC divides the whole rule set into smaller sub-rule sets and by doing so, it speeds up the table building time by 50 times compared to RFC when the considered rule set size is 10,000. With the rule set size increasing, the performance gap becomes larger.
A new system-on-a-chip (SOC) technology high Q post passivation inductors (2004)

This paper presents a new SOC scheme by adding high Q (>15) inductors on top of IC passivation layer. Affiliated with such a high Q inductor, a high performance RF CMOS chip can he achieved, which may replace some applications of GaAs chips. The high Q value of the inductor is attributed to the large gap formed by the thick polyimide located hetween the inductor body and IC passivation layer, as well as the thick metal traces of inductors. Conventional IC front-end process technology cannot offer these advantages as it places the inductor closer to the silicon substrate, and its metal is thinner than 2 p m. The manufacturing cost of post-passivation inductor is also much lower than that of font-end IC process in that the post passivation inductors can he fabricated in a more relaxed manufacturing environment Two kinds of inductor bodies, copper and gold, have been developed, respectively. At 5 GHz, the post passivation inductor demonstrated a Q factor as high as 24, which is much greater than that of the ones formed by IC front-end process that are positioned under the passivation layer (Q value lower than 10). The reliability results of the new SOC scheme will he also presented.
Effect of Cosolvents on the Structural Stability of Endoglucanase fromAspergillus aculeatus (2009)

The effects of cosolvents such as sucrose, glycerol, and sorbitol on endoglucanase have been studied by activity, circular dichroic spectroscopy, fluorescence, and apparent thermal transition temperature measurements. The endoglucanase activity increased by 4-fold at 40% cosolvent concentration under optimum conditions. The endoglucanase lost 50% of its activity when exposed to 90 degrees C for more than 30 min (1 h). In the presence of cosolvents, it maintained its original activity and native conformation as indicated by far UV-CD at 70 degrees C. The app T(m) increased from a control value of 57 degrees C to a value of 66 degrees C in the presence of 40% sucrose. The partial specific volume of endoglucanase was 0.723 mL/g in sodium acetate buffer. The preferential interaction parameters were negative in all cosolvents, and the maximum hydration of the protein was observed in 40% glycerol where the preferential interaction parameter was -0.126 g/g. The thermal stability of endoglucanase increased in the presence of cosolvents.
Processing Functional Polymers for the Fabrication of Low-Cost Biomedical MEMS Sensors in an All-Organic Approach (2013)

International audience
An Analysis of Differences between English and Chinese Tourism Texts (2019)

In the context of globalization, tourism serves as an increasingly important bridge in the mutual understanding among different countries. Tourism literatures transmit adequate information about tourist destinations with an aim to evoke readers’ interests to have a visit. Well-translated tourism texts help a lot in attracting overseas tourists. Therefore, it is of great importance to equip translators with the awareness of the major differences between Chinese and English tourism texts in order to make the targeted texts informative, acceptable and attractive to the targeted readers. The two chief differences, discourse structures and persuading approaches in particular, are explored in this essay. In terms of discourse structures, English tourism texts stress hypotaxis and develop linearly in the way of deduction, while Chinese texts emphasize parataxis and develop spirally in an inductive way. As for persuading approaches, concise and objective descriptions are common in English texts, but Chinese tourism literatures normally turn to flowery expressions and parallel structures, quotations as well as rhetoric devices to realize the vocative function.
An elbow extension neuroprosthesis for individuals with tetraplegia (1998)

Functional electrical stimulation (FES) of the triceps to restore control of elbow extension was integrated into a portable hand grasp neuroprosthesis for use by people with cervical level spinal cord injury. An accelerometer mounted on the upper arm activated triceps stimulation when the arm was raised above a predetermined threshold angle. Elbow posture was controlled by the subjects voluntarily flexing to counteract the stimulated elbow extension. The elbow moments created by the stimulated triceps were at least 4 N.m, which was sufficient to extend the arm against gravity. Electrical stimulation of the triceps increased the range of locations and orientations in the workspace over which subjects could grasp and move objects. In addition, object acquisition speed was increased. Thus elbow extension enhances a person's ability to grasp and manipulate objects in an unstructured environment.
Coordination-induced weakening of ammonia, water, and hydrazine X–H bonds in a molybdenum complex (2016)

Although scores of transition metal complexes incorporating ammonia or water ligands have been characterized over the past century, little is known about how coordination influences the strength of the nitrogen-hydrogen and oxygen-hydrogen bonds. Here we report the synthesis of a molybdenum ammonia complex supported by terpyridine and phosphine ligands that lowers the nitrogen-hydrogen bond dissociation free energy from 99.5 (gas phase) to an experimentally measured value of 45.8 kilocalories per mole (agreeing closely with a value of 45.1 kilocalories per mole calculated by density functional theory). This bond weakening enables spontaneous dihydrogen evolution upon gentle heating, as well as the hydrogenation of styrene. Analogous molybdenum complexes promote dihydrogen evolution from coordinated water and hydrazine. Electrochemical and theoretical studies elucidate the contributions of metal redox potential and ammonia acidity to this effect.
The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes (1999)

6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of 6Ckine expression in lymphoid organs is a prominent characteristic of mice homozygous for the paucity of lymph node T cell (plt) mutation. These mice show reduced numbers of T cells in lymph nodes, Peyer's patches, and the white pulp of the spleen. The genetic reason for the lack of 6Ckine expression in the plt mouse, however, has remained unknown. Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse.
HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY) (2014)

Aim. To study the prevalence of hyperuricemia in the Russian regions, depending on the climatic, geographical, socio-demographic characteristics and some cardiometabolic risk factors. Material and methods. Data from the ESSE-RF study from 10 regions of theRussian Federationare presented. All study participants were examined according to a uniform protocol. Measurements were standardized, biochemical tests were carried out in three Federal centers using the same methodology. The study was approved by independent Ethics committees, and all participants signed informed consent. Results. The prevalence of hyperuricemia was 16.8% (25.3% in men and 11.3% in women; p&lt;0.0001). Hyperuricemia incidence increases with age, does not depend on education, significantly associates with place of residence, elevated blood pressure, obesity and abdominal obesity, alcohol consumption and diuretics taking. After adjustment for all factors included in the regression analysis, prevalence of hyperuricemia in the Ivanovo Region is 1.4 times higher than this in the reference region (Tyumen), while prevalence of hyperuricemia in the Samara Region and theRepublicofNorth Ossetia-Alaniais 30% and 40 % lower. Conclusion. Prevalence of hyperuricemia inRussiais defined; regions with the highest and lowest prevalence are identified. Associations of hyperuricemia with some social and demographic characteristics as well as cardiovascular risk factors are revealed.
Kaurane-Type Diterpene Glycoside from the Stem Bark ofAcanthopanax trifoliatus (2004)

A new diterpene glycoside, acantrifoside D ( 1), as well as three known diterpenes (2 - 4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16alpha,17-dihydroxy- ent-kauran-19-oic acid 16- O-beta- D-glucopyranoside 19- O-beta- D-glucopyranosyl ester (1), 16alpha H,17-isovalerate- ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid ( 3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2 - 4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC50 values of 0.21, 0.15 and 0.19 mM, respectively.
Total Syntheses of the C19 Diterpenoid Alkaloids (–)-Talatisamine, (–)-Liljestrandisine, and (–)-Liljestrandinine by a Fragment Coupling Approach (2021)

The C19 aconitine-type diterpenoid alkaloids (–)-talatisamine, (–)-liljestrandisine, and (–)-liljestrandinine have been prepared in 31, 30, and 33 steps, respectively, from phenol. The synthetic approach features a 1,2-addition/semi-pinacol rearrangement as the key fragment coupling tactic. These efforts have also resulted in a correction to the original structure assignment of (–)-liljestrandisine.
Thin Silicon Film on Insulating Substrate (1973)

Experimental results on a new technique for making a thin silicon epitaxial layer on an insulating substrate are presented. The technique utilizes the anisotropy of the etch rate of silicon in the aqueous potassium hydroxide-isopropyl alcohol system. The silicon film can be either n‐ or p‐type with a thickness in the low micron range (under 3 /µm). The thickness variation can be controlled to ±0.5µm across a 2 in. diameter wafer.
Estradiol-Induced Synaptic Remodeling of Tyrosine Hydroxylase Immunopositive Neurons in the Rat Arcuate Nucleus (2008)

Gonadal steroids induce synaptic plasticity in several areas of the adult nervous system. In the arcuate nucleus of adult female rats, 17beta-estradiol triggers synaptic remodeling, resulting in a decrease in the number of inhibitory synaptic inputs, an increase in the number of excitatory synapses, and an enhancement of the frequency of neuronal firing. In the present paper, we studied the specificity of hormonal effects by determining the changes in synaptic connectivity of tyrosine hydroxylase (TH) immunoreactive (IR) neurons in the arcuate nucleus. We combined pre-embedding TH and post-embedding gamma-aminobutyric acid (GABA) immunostaining, and performed unbiased stereological measurements in gonadectomized and 17beta-estradiol-treated rats. We conclude that the synaptic connectivity of the TH-IR neurons is different from the other, nonlabeled population, and the response to estradiol is not uniform. TH-IR (dopaminergic) arcuate neurons of both male and female rats have more GABAergic (inhibitory) axosomatic inputs than the nondopaminergic population. Our study shows that the effect of 17beta-estradiol is sex and cell specific in the sense that not all arcuate neurons are affected by the structural synaptic remodeling. In ovariectomized females hormone treatment decreased the numerical density of GABAergic axosomatic synapses on TH-IR, but not on nondopaminergic, neurons, whereas in orchidectomized males, 17beta-estradiol treatment increased inhibitory synapses onto nondopaminergic neurons but did not affect the number of inhibitory terminals onto TH-IR neurons. The hormone-induced plastic changes in synaptic connectivity of TH-IR neurons may serve as the morphological basis for the cyclical regulation of the anterior pituitary.
Surface growth for molten silicon infiltration into carbon millimeter-sized channels: Lattice–Boltzmann simulations, experiments and models (2015)

The process of liquid silicon (Si) infiltration is investigated for channels with radii from 0.25[Formula: see text][mm] to 0.75[Formula: see text][mm] drilled in compact carbon (C) preforms. The advantage of this setup is that the study of the phenomenon results can be simplified. For comparison purposes, attempts are made in order to work out a framework for evaluating the accuracy of simulations. The approach relies on dimensionless numbers involving the properties of the surface reaction. It turns out that complex hydrodynamic behavior derived from second Newton law can be made consistent with Lattice–Boltzmann (LB) simulations. The experiments give clear evidence that the growth of silicon carbide (SiC) proceeds in two different stages and basic mechanisms are highlighted. LB simulations prove to be an effective tool for the description of the growing phase. Namely, essential experimental constraints can be implemented. As a result, the existing models are useful to gain more insight on the process of reactive infiltration into porous media in the first stage of penetration, i.e. up to pore closure because of surface growth. A way allowing one to implement the resistance from chemical reaction in Darcy law is also proposed.
Pistoia, een cultuur van het jonge kind (2022)

De vele bezoekers uit Nederland en Vlaanderen die de uitstekende voorzieningen voor jonge kinderen in Pistoia bezoeken vragen zich telkens weer af hoe deze stad in Toscane erin geslaagd is om zo een rijke cultuur van het jonge kind te ontwikkelen. Dit boek beschrijft hoe de intense samenwerking tussen pedagogen, onderzoekers en beleidsmensen ertoe geleid heeft dat er een klimaat is ontstaan waarin deze cultuur vorm kreeg. Aan de hand van voorbeelden en illustraties wordt beschreven hoe via experimenten en projecten deze cultuur zich ontwikkelde: hoe een stimulerende visie op de ruimte werd geconstrueerd, hoe men erin slaagde die unieke band met de ouders vorm te geven, hoe de link tussen de kinderen en de stad Pistoia werden gelegd. De auteurs illustreren hoe een klimaat van samen leren, van kritisch reflecteren op de praktijk aan de basis ligt van deze bijzonder geslaagde innovaties. Dit boek is bijzonder boeiend voor allen die betrokken zijn bij de opvoeding en de zorg voor de kinderen tussen 0 en 6 jaar, praktijkmedewerkers en opleiders en ook ouders. Deze cultuur van gastvrijheid en participatie die de voorzieningen van Pistoia zo rijkt maakt voor kinderen en ouders zal zonder twijfel veel inspiratie bieden voor allen die investeren in innovatie en kwaliteitsverbetering van voorzieningen voor jonge kinderen in Nederland en Vlaanderen
Solving the nuclear pore puzzle (2022)

Using a battery of tools, the architecture of the nuclear pore complex is revealed.
Newt-derived extracellular vesicles promote mammalian nerve growth (2023)

Abstract Newts have the extraordinary ability for regeneration, including the ability to regrow nerve and retinal tissue, and even amputated limbs. In contrast, mammals lack broad regenerative capabilities. While the molecular basis of newts’ regenerative ability is the subject of active study, the underlying paracrine signaling factors remain largely uncharacterized. Extracellular vesicles (EVs) play an important role in cell-to-cell communication via EV cargo-mediated regulation of gene expression patterns within the recipient cells. Here, we report that newt myogenic precursor cells (A1 cells) secrete EVs (A1EVs) that contain messenger RNAs associated with early embryonic development, neuronal differentiation, and cell survival. Exposure of rat primary superior cervical ganglion (SCG) neurons to A1EVs increased neurite outgrowth, facilitated by increases in mitochondrial respiration. Canonical pathway analysis pinpointed activation of NGF/ERK5 signaling in SCG neurons exposed to A1EV, which we validated experimentally. Thus, newt EVs drive mammalian neurite growth and complexity.
Investigation on the simulation of the reactive extrusion of nylon 6 (1995)

Abstract In this article, a novel simulation of the processing conditions of the anionic ring‐opening polymerization of nylon 6 in a counterrotating twin‐screw extruder by use of a modified Haake Rheometer run at elevated temperatures is described. Experimental results for several combinations of processing parameters are presented. General relations between processing parameters, conversion ratio, and molecular weight of the product are observed. These observations can be used in the eventual scaling up of investigation to an actual twinscrew extruder. © 1995 John Wiley &amp; Sons, Inc.
Potential-Induced Phase Transitions in 2,2‘-Bipyridine and 4,4‘-Bipyridine Monolayers on Au(111) Studied byin SituScanning Tunneling Microscopy and Atomic Force Microscopy (1996)

The formation and structure of 2,2'-bipyridine (22BPY) and 4,4'-bipyridine (44BPY) monolayers on Au(111) substrate have been studied as a function of the substrate potential. At high potentials, both molecules adsorb onto the substrate and stand vertically with their nitrogen atoms facing the Au(111). The vertically standing molecules stack, like rolls of coins, into polymer-like chains which pack closely in parallel to form ordered monolayers. Decreasing the potential to a critical value, the 22BPY chains become randomly oriented via a reversible order−disorder phase transition. The phase transition, as revealed by scanning tunneling microscopy, is driven by a potential dependent attractive force between the chains. The attractive force is believed to be a substrate-mediated effective force which arises as an adsorbed 22BPY perturbs its surrounding local surface potential and thus the nearby molecules. This hypothesis is supported by a quantitative investigation of the local surface potential using a self-consistent density functional method. In contrast to 22BPY, the 44BPY chains dissolve instead of becoming randomly oriented at low potentials. This behavior may be due to that 44BPY is not as strongly adsorbed on the surface as 22BPY because it has only one nitrogen facing the surface.