gebhart/patrepeval huggingface dataset:
A prospective study of lithium continuation therapy in depressed patients who have responded to electroconvulsive therapy. (1995)

Twenty-eight of 34 patients with major depression who completed a course of electroconvulsive therapy (ECT) and were classified as responders were administered lithium carbonate (Li) continuation therapy in the context of an open, prospective study. Twenty-four patients were followed for 6 months or until relapse; four patients dropped out of follow-up while still in remission. The probability of completing 6 months without relapse (by survival analysis, including the patients who dropped out as censored observations) was 65%. The eight patients who relapsed into depression all did so within 13 weeks. They were characterized by a shorter duration of their index depressive episode, a greater likelihood of having suffered an additional depressive episode in the preceding 12 months, and failure of an adequate trial of antidepressant medication before the ECT course. Novel pharmacological strategies may be needed in the post-ECT continuation therapy of patients who have a prior history of relapse and are demonstrably resistant to antidepressant medication.
Deafness (2003)

Abstract Hearing loss is the most frequent of the sensory defects. 30% of the cases are syndromic (deafness is accompanied by other symptoms). The nonsyndromic forms can be due to environmental or genetic factors. A variety of genes can be responsible for deafness, among them several connexins, unconventional myosins, and mitochondrial genes.
Improving search engine retrieval using a compound splitter for Swedish (2005)

In this paper we have investigated 128 high frequent Swedish compound queries (6.2 per thousand) with no search results among 1.6 million searches carried out at nine public web sites containing all together 100,000 web pages in Swedish. To these compound queries we added a compound splitter as a pre-processor and we found that after decompounding these queries they gave relevant results in 64 percent of the cases instead of zero percent hits. We give also examples on some rules for optimal compound splitting in a search situation. 1
Monitoring Chat Users (2004)

1 Introduction 61.1 Fonctionnement g´en´eral . . . . . . . . . . . . . . . . . . . . . 72 Portage 82.1 Langage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82.2 Interface graphique . . . . . . . . . . . . . . . . . . . . . . . . 82.3 Remarques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 D´everminage 103.1 D´econnection r´eseau . . . . . . . . . . . . . . . . . . . . . . . 103.2 Parcours d’un FSERV . . . . . . . . . . . . . . . . . . . . . . 104 Fonctionnalit´es ajout´ees 124.1 Syst`eme de sauvegarde . . . . . . . . . . . . . . . . . . . . . . 124.1.1 Logs . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124.1.2 Sauvegarde automatique . . . . . . . . . . . . . . . . . 154.1.3 Sauvegarde des pr´ef´erences . . . . . . . . . . . . . . . . 164.2 Rapport HTML . . . . . . . . . . . . . . . . . . . . . . . . . . 175 Fonctionnalit´es retir´ees 205.1 Multi-protocoles . . . . . . . . . . . . . . . . . . . . . . . . . . 205.2 Logiciel de chat . . . . . . . . . . . . . . . . . . . . . . . . . . 206 Conclusion 216.1 G´en´eralit´es . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216.2 Notes personelles . . . . . . . . . . . . . . . . . . . . . . . . . 21
Fragmentation of Menthyl- and Neomenthyloxychlorocarbenes:  Elimination and Substitution Reactions of Alicyclic Oxychlorocarbenes (2003)

Fragmentations of menthyloxychlorocarbene (5) and neomenthyloxychlorocarbene (6) follow distinct pathways to (largely) stereochemically retained substitution products from 5 and elimination products from 6, closely resembling the product distributions from deaminations of the corresponding menthyl- and neomenthylamines.
Abstract 16838: Circulating miRNAs Can Predict Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients in a Sex-dependent Manner (2015)

Introduction: MicroRNAs (miRs) are small noncoding ~22 nucleotide RNAs capable of modulating the expression of many genes. Our hypothesis was that circulating miRs are useful biomarkers of cardiac allograft vasculopathy (CAV) in pediatric heart transplant recipients (PHTR). Methods: An array for 765 miRs was performed using the Applied Biosystems technology normalized by a global normalization method as determined by the Expression Suite Software. Serum was obtained from 132 PHTR at the time of routine surveillance catheterization with coronary evaluation (intravascular ultrasound [IVUS] performed if ≥ 25 kg). Rejection free CAV+ patients were matched by age at transplant and time since transplant to CAV- controls. Statistical analysis was performed using the Wilcoxon test. Results: Samples were analyzed from 32 CAV+ PHTR matched to 17 CAV-controls. There were no significant differences between expression of miRs between CAV+ and CAV- PHTR alone, but differences in expression were found when PHTR were separated by sex. miRs significantly upregulated in females (F) included miRs-636 (F with both IVUS and angiographic CAV; p=0.008), -636 and -523 (F with a maximal intimal thickness [MIT] of ≥ 0.5mm; p=0.008 and 0.01, respectively), and -509 and -636 (F with any diagnosis of CAV; p=0.01 and p=0.01, respectively). miRs significantly upregulated in males (M) included miRs-422a (M with both IVUS and angiographic CAV; p=0.007), -422a and let-7e (M with a MIT of ≥ 0.5mm; p=0.003 and p=0.01, respectively), and -422a (M with any diagnosis of CAV; p=0.002). miR-19a was significantly downregulated in in M with any diagnosis of CAV (p=0.04). Boxplots highlighting differential expression of miRs by sex in CAV are shown in Figure 1. Conclusions: miRs are differentially expressed between PHTR with CAV on the basis of sex. A unique biomarker signature of miRs that are specific to PHTR with CAV would be valuable in the risk stratification of this challenging patient population.
An air refractometer for interference length metrology (1965)

A refractometer for the measurement of the refractive index of the surrounding air is described, in which interference fringes are produced between two beams, one propagated in air, the other in vacuum. The accuracy aimed at is one part in 108, corresponding to the accuracy of the best vacuum wavelength standards used in the length measurement of mechanical standards. The refractometer is placed with the comparator inside an airtight isothermal enclosure and is operated from outside.
Application of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effects (2005)

Bone morphogenetic proteins (BMPs) have been extensively studied since the discovery of agents within bone that could induce bone formation at ectopic sites by Urist in the 1960s. Extensive preclinical research has been carried out showing the efficacy of these products in promoting bone healing. Clinical trials are encouraging, with meta-analysis of results revealing better rates of healing than treatment with autologous bone grafting (risk ratio [RR]: 0.845; 95% confidence interval [CI]: 0.772 - 0.924; p < 0.001 for clinical outcome and RR: 0.884; 95% CI: 0.825 - 0.948; p < 0.001 for radiological outcome). Preclinical and clinical safety assessments have revealed little evidence of toxic effects and there have been few reports of adverse events related to their use. A small rate of immunological reaction following administration, resulting in antibody formation, has been observed in some patients, without clinical consequence, although the long-term implications of this are unknown. Ongoing research is revealing that BMPs act on an extremely wide range of body tissues in a variety of manners and this is far from fully understood. It should be noted, however, that given the role of BMP as a differentiation factor, the production of undifferentiated neoplastic tissue seems unlikely. It has also been shown in an animal model that artificially administered BMP can cross the placenta and subsequently be detected in the growing embryo. As this area has been little investigated, use in pregnancy is currently contraindicated. Until the long-term safety profile is more fully documented it would seem sensible to continue to carefully control use and monitor patients closely. However, the current evidence is very promising.
Hydroxyapatite/polymer composites for bone replacement (1997)

hydroxyapatite/polyester-ether ....
Electromechanical Properties of a Humido-Sensitive Conducting Polymer Film (2000)

Polypyrrole films containing tetrafluoroborate were electrochemically synthesized, and stress generated in the film under application of an electric voltage was measured in air under various strains. It was found that the film generated contractile stress in response to the applied voltage that reached 6.1 MPa under 2 V, which was 4 orders of magnitude larger than its own weight. The mechanism was based on a dimensional change of the film that was expressed by two processes both caused by the Joule heating: one was the contraction due to the desorption of water vapor, and the other was the thermal expansion of polymer chains, which was different from electrochemical or chemical doping in an electrolyte solution or in a redox gas atmosphere. The generated stress under 2 V increased to 8.9 MPa upon stretching the film by 1%, which could be associated with the Young's modulus of the film rose due to the desorption of water vapor that plasticized polymer chains. The work capacity of the film increased as the applied voltage became higher and reached 48.2 kJ m-3 at 3 V, while the energy efficiency, defined as the ratio of work capacity to the electric energy, was on the order of 10-3%.
Publisher's Note: Blackbox quantization of superconducting circuits using exact impedance synthesis [Phys. Rev. B 90, 134504 (2014)] (2014)

1 such that R 1 = min Re[Z(j)] and min Re[Z(j 1 )] =....
THE FLUOROMETRIC MEASUREMENT OF THE NUCLEOTIDES OF RIBOFLAVIN AND THEIR CONCENTRATION IN TISSUES (1949)

Warburg and Christian (I), in describing the preparation of flavinadenine dinucleotide (FAD), mentioned that whenever dinucleotide solutions developed a greenish fluorescence they were found to have lost their coenzyme activity.On further investigation of this phenomenon it has been found that there occurs a lo-fold increase in fluorescence when FAD is split to riboflavin phosphate (flavin mononucleotide) or to free riboflavin.This change in fluorescence has proved to be a practical means of measuring FAD.Since flavin mononucleotide (FMN) can be distinguished from riboflavin on the basis of its distribution coefficient between benzyl alcohol and aqueous solutions (2), ready analytical means are available for measuring separately FAD, FMN, and riboflavin, the three forms of riboflavin encountered in biological material.A description is given below for the fluorometric measurement of these three forms of riboflavin.The measurements are considered to be much simpler than the enzymatic procedures which were the available methods hitherto.Data are given for the fluorescent behavior of FAD, FMN, and riboflavin, the stability of FAD, and the concentration of each of these three forms of riboflavin in normal and riboflavin-deficient tissues of the rat. Measurement of Ribojlavin, FMN, and FAD in Tissues
Characteristics of Drug Poisonings Presenting to the Emergency Department: An Electronic Medical Record Database Analysis (2021)

Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project. Projects often represent an area of interest and need that has been recognized by the host institution’s pharmacy department. Projects are presented as a poster at an annual CSHP Ontario Branch Residency Research Night, and many eventually go on to be published in a peer-reviewed journal.
Rare germline variants in known melanoma susceptibility genes in familial melanoma (2017)

Known high-risk cutaneous malignant melanoma (CMM) genes account for melanoma risk in <40% of melanoma-prone families, suggesting the existence of additional high-risk genes or perhaps a polygenic mechanism involving multiple genetic modifiers. The goal of this study was to systematically characterize rare germline variants in 42 established melanoma genes among 144 CMM patients in 76 American CMM families without known mutations using data from whole-exome sequencing. We identified 68 rare (<0.1% in public and in-house control datasets) nonsynonymous variants in 25 genes. We technically validated all loss-of-function, inframe insertion/deletion, and missense variants predicted as deleterious, and followed them up in 1, 559 population-based CMM cases and 1, 633 controls. Several of these variants showed disease co-segregation within families. Of particular interest, a stopgain variant in TYR was present in five of six CMM cases/obligate gene carriers in one family and a single population-based CMM case. A start gain variant in the 5'UTR region of PLA2G6 and a missense variant in ATM were each seen in all three affected people in a single family, respectively. Results from rare variant burden tests showed that familial and population-based CMM patients tended to have higher frequencies of rare germline variants in albinism genes such as TYR, TYRP1, and OCA2 (P < 0.05). Our results suggest that rare nonsynonymous variants in low- or intermediate-risk CMM genes may influence familial CMM predisposition, warranting further investigation of both common and rare variants in genes affecting functionally important pathways (such as melanogenesis) in melanoma risk assessment.
The diagnostic significance of anginal symptoms. (1974)

Data obtained from a detailed clinical history were correlated with findings at cardiac catheterization in 49 patients who had coronary artery disease and in 23 patients who had recurrent chest pain but normal coronary angiograms. Classical descriptions of angina pectoris were applicable to both groups. Certain combinations of factors including response to nitroglycerin, relationship to exertion, presence of a fourth heart sound, and radiation of pain to the left arm appeared to be of discriminatory value. In the group with coronary lesions, factors suggestive of extensive multiple-vessel involvement included the triad of rest-related, nocturnal, and postprandial pain, radiation of pain to regions other than the left arm, and poor responsiveness to nitroglycerin. ( JAMA 229:1196-1199, 1974)
Color Quality Analysis of a System for Digital Distribution and Projection of Cinema Commercials (2005)

The partial results of a collaborative research project conducted by researchers at Gjøvik University College and Lillehammer University College are described in this paper. The goal of the project is to develop methods and tools for improving the control of color information in the production and presentation of digital video. The project represents a unique attempt to bring together two scientific communities—graphic arts and television/video production—on a theme of common interest, namely color. The color quality achieved by a system for digital distribution and presentation of cinema commercials has been investigated. Results show that the “quality bottleneck” is the digital projector. The “business-type” projector does not yield sufficient image quality, especially in large theaters.
Combinatorial Methods in Catalysis (2002)

This chapter contains sections titled: Introduction Combinatorial Catalysis Combinatorial Organic and Organometallic Catalysis Metal-binding Ligands, Polymeric Enzyme Mimetics, and Metal Complexes as Enzyme Mimetics Combinatorial Approaches to Metal-binding Ligands Combinatorial Functionalization of Metal-binding Core Structures Combinatorial Synthesis of Metal-binding Ligands from Building Blocks with Metal-coordinating Functionalities Miscellaneous Combinatorial Libraries of Polymeric Catalysts as Enzyme Mimetics Combinatorial Synthesis Enzyme Mimetics Hydrolytically Active Metal Complexes Evolutionary Solid-phase Synthesis of Oxygenase Mimics Libraries of Organic Acylation Catalysts Combinatorial Catalysis in Asymmetric Synthesis Combinatorial Catalyst Libraries in Enantioselective Additions of Dialkyl Zinc Reagents Ligands for the Lewis Acid-catalyzed Asymmetric Aza-Diels–Alder Reaction Divergent Ligand Synthesis for Enantioselective Alkylations Chiral Phosphine Ligands for Asymmetric Hydrogenation Asymmetric Reactions Catalyzed by Schiff Base-type Ligands – the Positional Scanning Approach Identification of Novel Catalysts for the Asymmetric Epoxidations via the Positional Scanning Approach Multidimensional Combinatorial Screening Catalyst Discovery and Optimization Using Catalyst Arrays Parallel Array Screening for Catalyst Optimization Using Discovery and Focused Ligand Libraries One-pot, Multisubstrate Screening Combinatorial Approaches to Olefin Polymerization Catalysts Combinatorial Inorganic Catalysis Combinatorial Libraries of Homogeneous Polyoxometalate-based Catalysts Combinatorial Libraries and High-throughput Screening of Heterogeneous Polyoxometalate Catalysts Combinatorial Heterogeneous Catalysis Introduction Case Studies Oxidative Dehydrogenation of Ethane Oxidative Dehydrogenation of Propane Catalytic Oxidation of CO and the Reduction of NO Combinatorial Electrocatalysis Electrocatalysts for Fuel Cells Combinatorial Electrosynthesis Novel High-throughput Screening Tools Infrared Screening Tools Infrared Thermography High-throughput Infrared Spectroscopy Optical High-throughput Screening Techniques Colorimetric Assays Resonance-enhanced Multiphoton Ionization (REMPI) Photothermal Deflection Enantiomeric Excess by Circular Dichroism High-throughput Screening Using Mass Spectrometry Scanning Mass Spectrometry “Mass Tags” as Chirality Probes Electronic High-throughput Methods Electrochemical Analysis with Electrode Arrays Solid-state Temperature Sensors Solid-state Gas Sensors Array Reactors Array Microreactors Micromachined Array Reactors Catalysis on a Chip Capillary Array Electrophoresis Summary and Outlook Acknowledgements References
SeFAR Integration TestBed for See and Avoid Technologies (2005)

For unmanned air vehicles (UAVs) to operate freely in national airspace (NAS), they must have an on-board see and avoid (SAA) system capable of providing an “equivalent level of safety” (ELOS) to manned aircraft. Northrop Grumman had developed and validated through extensive computer modeling and simulation such SAA requirements, preferred sensing suites, and system architecture concepts in the recently completed Autonomous Flight Control Sensing Technology (AFCST) program funded by the Air Force Research Laboratory (AFRL). Following a successful completion of the AFCST program, Northrop Grumman is further developing a hardware-in-the-loop (HWIL) integration test bed under the Sensing for UAV Awareness (SeFAR) program also funded by AFRL. The SeFAR objective is to verify the SAA system attributes identified by AFCST through additional real-time algorithm and software development and their implementation and integration into a realistic HWIL simulation environment including hazardous failure conditions and associated safety measures. This paper describes the SeFAR test-bed architecture and the associated hardware and software designs.
Pluronic micelles as a tool for low-molecular compound vector delivery into a cell: effect of Staphylococcus aureus enterotoxin B on cell loading with micelle incorporated fluorescent dye. (1992)

We carried out a cytophotometric study of the DNA content of basal and suprabasal keratinocytes using involved and uninvolved histological sections of epidermis from psoriatic patients using the Feulgen technique. The reference 2C value of the DNA content was obtained from lymphocyte nuclei in a sub-epidermal infiltrate from normal skin. According to the DNA content profiles obtained for the keratinocytes of psoriatic patients, individuals were classified into three groups: Group 1, composed of individuals with a monomodal diploid profile and preferential keratinocytes with a 2C DNA content and, hence, a low proliferation activity; Group 2, consisting of patients with significantly increased 2C-4C and 4C populations; and Group 3, made up of individuals with high proportions of 4C and hyperdiploid (6C, 8C, and > 8C) keratinocytes. The results obtained in this work and the observed changes in the proliferative activity of the keratinocytes in the three groups of patients led us to suggest that the cytophotometric determination of the DNA content of basal and suprabasal keratinocytes may be useful as a prognostic criterion for the classification of psoriatic patients in terms of the extent of alteration of their proliferative epidermal activity.
Optimized resource allocation for the uplink of SFBC-CDMA systems (2008)

In this paper we present an optimized resource allocation algorithm for the uplink of space frequency block coded code division multiple access (SFBC-CDMA) systems. The algorithm allocates appropriate base transceiver stations (BTS), antenna array sub system and frequency subcarrier blocks to users such that the pair wise cross correlation between the users is minimized while maximizing the channel coherence time. The intermediate effects such as reduction of the channel estimation error and higher signal powers culminate into more cost effective multiple input multiple output (MIMO) operation. The proposed algorithm shows a noticeable improvement in the bit error rate of the users and the bandwidth efficiency of the system compared to random resource assignment.
The PGF2?? Analog Fluprostenol Activates Motor And GSK-3?? In The A7R5 Smooth Muscle Cell Line (2005)

Molecules that stimulate muscle growth may be therapeutic for muscle loss associated with aging, injury, or disease. However, few factors have been demonstrated to unequivocally increase muscle cell size. As the biochemistry of muscle growth is experimentally revealed, some common intracellular signaling pathways appear among the primary stimuli. For example, evidence exists that the stretch-induced growth of skeletal, cardiac and smooth muscle is mediated, in part, by the local production of the prostaglandin F-2α(PGF-2mU?). Although recognized as a potent stimulator of protein synthesis the signaling pathways activated by PGF2α?have not been fully delineated. PURPOSE To determine the effect of fluprostenol treatment on the activation of the p70 ribosomal s-6 kinase (p70S6k), mammalian target of rapamycin (mTOR) and glycogen synthase (GSK-3β) pathways. METHODS Embryonic rat thoracic aorta smooth muscle cells (A7R5) were obtained from American Type Culture Collection (Rockville, MD). Cells were grown in DMEM supplemented with 10% fetal bovine serum and stimulated with the FP agonist fluprostenol (1 μM) for 15 and 30 minutes. Western blotting analysis and scanning densitometry were employed to quantify the expression and activation (phosphorylation) of p70S6k, mTOR and GSK-3. RESULTS We demonstrate that fluprostenol stimulation: 1.) increased A7R5 cell size significantly within 48 hours (p<0.05), 2.) increases the phosphorylation of mTOR at 15 and 30 minutes (29.1 ± 3.1 and 72.1 ± 5.4, respectively, p <0.05), 3.) increases the phosphorylation of GSK-3βat 15 and 30 minutes (31.1 ± 1.8 and 57.7 ± 3.2, respectively, p <0.05), 3.) increases the mTOR dependent phosphorylation of p70 (Thr389) at 30 minutes (39.4 ± 4.3 p <0.05), and 4.) increases the ERK1/2-dependent phosphorylation of p70 (Thr421/Ser424) at 30 minutes (58.6 ± 5.6% p <0.05). CONCLUSIONS The data suggests that p70, mTOR and GSK-3βare involved in hypertrophic response to prostaglandin F2α?analog fluprostenol in the smooth muscle cell line A7R5. Supported by NIH grants AG20370; RR16477.
13. The cyanoethylation of amines and arsines (1949)

R. C. Cookson and F. G. Mann, J. Chem. Soc., 1949, 67 DOI: 10.1039/JR9490000067
Innovations in CT Dose Reduction Strategy: Application of the Adaptive Statistical Iterative Reconstruction Algorithm (2009)

The ASIR reconstruction algorithm is a promising technique for providing diagnostic quality CT images at significantly reduced radiation doses.