gebhart/patrepeval huggingface dataset:
Recognition of Diverse Proteins by Members of the Immunoglobulin Superfamily:  Delineation of the Receptor Binding Site in the Human CD6 Ligand ALCAM (1996)

The CD6-ALCAM (activated leukocyte cell adhesion molecule) interaction, which mediates thymocyte--thymic epithelial cell adhesion, is a previously unobserved type of protein--protein interaction that involves members of the scavenger receptor cysteine rich protein superfamily (SRCRSF) and the immunoglobulin superfamily (IgSF). Targeted mutagenesis of ALCAM reveals that residues which constitute the CD6 binding site cluster on the predicted A'GFCC'C" face of its N-terminal Ig domain. These results, in conjunction with recent analyses of interactions involving other IgSF members, suggest that this region in IgSF cell surface proteins is most suitable to mediate interactions with different ligands irrespective of their structure. The CD6 binding site in ALCAM is conserved across species, and nonconserved residues in ALCAM and its murine homolog map to the beta-sheet face opposite to the CD6 binding site. This provides a molecular rationale for the inability to obtain murine monoclonal antibodies against the receptor binding domain which block the CD6-ALCAM interaction.
411 Increased dietary soybean meal does not affect performance during a PRRSV-Mycoplasma hyopneumoniae challenge (2016)

Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (MHP) are 2 significant respiratory pathogens in finishing pigs, often found in tandem. Recent anecdotes have implied that increasing soybean meal content of diets can be beneficial in pathogen-challenged pigs, while other reports suggest similar benefits by increasing the use of synthetic AA, specifically Trp. The objective of this study was to determine if increased synthetic Trp replacing a portion of SBM would impact performance of late finishing pigs dual-challenged with PRRSV and MHP. Ninety-six mixed sex pigs (120 ± 1.4 kg BW), were selected and randomly assigned to a high SBM (CON; 9 pens/trt) or synthetic Trp (SYN; 9 pens/trt) diet. Both diets were formulated to contain 0.70% TID Lys and were isocaloric; only crude protein was different between CON and SYN diets (15.9 vs. 13.5%, respectively). After 96 d on test diets, all pigs were inoculated intratracheally with MHP and intramuscularly with a field strain of PRRSV. Growth performance and feed efficiency were determined until pigs reached market weight (∼138 kg BW), after which, carcass data and lung lesion scores were assessed. During the 96 d pre-challenge period, no performance differences were detected between the 2 dietary treatments. As expected, antibody titers for PRRSV and MHP increased post inoculation. However, change in PRRSV antibody titers from 0 to 28 d post inoculation tended (P = 0.09) to be increased in SYN verses CON pigs. MHP antibody titers and lung lesion scores did not differ between treatments. For the 28 d post-challenge period, there was no difference in ADG, ADFI or G:F. There was also no difference in hot carcass weight, yield percentage or muscle depth (P > 0.10). However, the SYN pigs had an increase in carcass fat depth compared to the CON (P = 0.01). Conversely, there was a tendency (P = 0.09) for carcass lean percent to be increased in CON pigs (57.6 vs. 57.1%, respectively). Altogether, these data indicate that diets with increased synthetic AA or decreased SBM do not alter pig performance during a late breaking respiratory health challenge.
Milde voedselverwerkingstechnologie III : nieuwe technologie combineert drogen en expanderen (2004)

Er is een nieuwe technologie voor het drogen en tegelijkertijd expanderen van producten. Gebruik wordt gemaakt van de combinatie van verwarmde lucht met hoge snelheid, verkregen in een Torbed-reactor, en microgolfverhitting. Voordelen van deze milde behandeling zijn behoud van productkwaliteiten en goede rehydratatie-eigenschappen bij een korte procestijd. Belangrijkste pluspunt is evenwel dat het volume van het geëxpandeerde product tot vijf keer zo groot is als van het regulier gedroogde product
Serum TSH and Daily Physical Activity in a Cohort of Nonagenarians: Results from the Mugello Study (2022)

High-normal serum TSH and low-normal fT4 are associated with higher levels and intensity of daily PA, together with higher MIPAT continuity, in the oldest-old.
Control Mechanisms of Retinal Vein Pressure: Evaluation in the Cat Using an In Situ Infusion Micropipette (1996)

Vein pressure in the cat retina is maintained above intraocular pressure by mechanisms other than active control. A passive high-resistance segment resides somewhere within the optic nerve possibly within the lamina cribosa or prelaminar region.
ChemInform Abstract: A Novel Rearrangement Forming 4,5,6,11‐Tetrahydrobenzo(6,7)cycloocta‐(1,2‐b)thiophen‐6,11‐imines. (1990)

Abstract The crude carbamates (V), prepared as shown in the reaction scheme, are treated with hydrobromic acid to perform a rearrangement, yielding the tetracyclic carbamates (VII) via the spiro compounds (VI).
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1-Ren-2 transgenic rats (2014)

Recent studies have shown that the long-term antihypertensive action of soluble epoxide hydrolase inhibition (sEH) in angiotensin-II (AngII)-dependent hypertension might be mediated by the suppression of intrarenal AngII levels. To test this hypothesis, we examined the effects of acute (2 days) and chronic (14 days) sEH inhibition on blood pressure (BP) in transgenic rats with inducible AngII-dependent hypertension. AngII-dependent malignant hypertension was induced by 10 days' dietary administration of indole-3-carbinol (I3C), a natural xenobiotic that activates the mouse renin gene in Cyp1a1-Ren-2 transgenic rats. BP was monitored by radiotelemetry. Acute and chronic sEH inhibition was achieved using cis-4-(4-(3-adamantan-1-yl-ureido)cyclohexyloxy) benzoic acid, given at doses of 0.3, 3, 13, 26, 60 and 130 mg/L in drinking water. At the end of experiments, renal concentrations of epoxyeicosatrienoic acids, their inactive metabolites dihydroxyeicosatrienoic acids and AngII were measured. Acute BP-lowering effects of sEH inhibition in I3C-induced rats was associated with a marked increase in renal epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids ratio and acute natriuresis. Chronic treatment with cis-4-(4-(3-adamantan-1-yl-ureido)cyclohexyloxy) benzoic acid in I3C-induced rats elicited dose-dependent persistent BP lowering associated with a significant reduction of plasma and kidney AngII levels. Our findings show that the acute BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats is mediated by a substantial increase in intrarenal epoxyeicosatrienoic acids and their natriuretic action without altering intrarenal renin-angiotensin system activity. Long-term antihypertensive action of cis-4-(4-(3-adamantan-1-yl-ureido)cyclohexyloxy) benzoic acid in I3C-induced Cyp1a1-Ren-2 transgenic rats is mediated mostly by suppression of intrarenal AngII concentration.
Screw sense selective polymerization of achiral lsocyanides catalysed by complexes of nickel(II) and optically active amines (1986)

P. C. J. Kamer, R. J. M. Nolte and W. Drenth, J. Chem. Soc., Chem. Commun., 1986, 1789 DOI: 10.1039/C39860001789
Development of the Gd(0001) band structure with film thickness (1991)

By growing gadolinium films on W(110), it has been possible to observe the development of the Gd(0001) band structure with increasing film thickness. The changes in the 5d bands as a result of exposure to oxygen or the development of the valence-band structure with increasing film thickness lead to changes in the 5p multiplet oscillator strengths. These changes are a result of the influence of the band structure upon the final-state effects that give rise to such multiplet structures. This study provides conclusive evidence that there is a 5d contribution to the shallow 5p multiplet photoemission core-level structure.
Focal brain ischemia in mice does not cause electrophysiological signs of critical illness neuropathy (2020)

Abstract Objective: Critical illness polyneuropathy (CIP) is a common complication of severe systemic illness treated in intensive care medicine. Ischemic stroke leads to an acute critical injury of the brain with hemiparesis, immunosuppression and subsequent infections, all of which require extended medical treatment. Stroke-induced sarcopenia further contributes to poor rehabilitation and is characterized by muscle wasting and denervation in the paralytic, but also the unaffected limbs. Therefore, we asked whether stroke leads to an additional CIP-like neurodegeneration. Results: Focal brain ischemia was induced in adult mice by 60-minute middle cerebral artery occlusion (MCAo) following reperfusion and led to functional deficits and marked hemispheric brain atrophy. Nerve conduction function and muscle potentials were measured in the ipsilateral sciatic nerve and gastrocnemius and quadriceps muscle with electroneurography/-myography on days 10, 22, 44 after stroke. An additional crush-injury to the sciatic nerve was included in two sham mice as positive control (sham+). We found no differences in nerve conduction function nor spontaneous electromyographic activity between MCAo and sham animals. Sham+ mice developed marked reduction of the motor action potential amplitudes and conduction velocities with pathologic spontaneous activity. In conclusion, we found no peripheral nerve dysfunction/ degeneration as signs of a CIP-like phenotype after MCAo.
Significance of TLR4/MyD88 expression in breast cancer. (2015)

TLR4 and MyD88 expression might be associated with breast cancer growth and regional and distant metastases.
Modeling the structure and dynamics of the auxin signaling network in the shoot apical meristem (2010)

International audience
Reification, polymorphism and reuse (2000)

This paper presents three design principles to support the development of large-scale applications and take advantage of recent research in new interaction techniques: Reification turns concepts into first class objects, polymorphism permits commands to be applied to objects of different types, and reuse makes both user input and system output accessible for later use. We show that the power of these principles lies in their combination. Reification creates new objects that can be acted upon by a small set of polymorphic commands, creating more opportunities for reuse. The result is a simpler yet more powerful interface.
Stratospheric Final Warmings fall into two categories with different evolution over the course of the year (2022)

Abstract In early spring the stratospheric zonal circulation reverses from westerly to easterly. The transition, called Stratospheric Final Warming (SFW), may be smooth and late, mainly controlled by the solar radiative heating of the polar region, or early and abrupt with rapid increase of polar temperature and deceleration of the zonal wind, forced by the planetary wave activity. Here we present a study, based on 71 years meteorological reanalysis data. Two composites of radiative and dynamical SFWs have been built. There is a very significant difference in the evolution during the year of polar temperature and 60°N zonal wind between the two composites. The state of the polar vortex on given month is anticorrelated with its state 2 to 3 months earlier. Early winter is anticorrelated with mid-winter and mid-winter with late winter/early spring. The summer stratosphere keeps a memory of its state in April–May after the SFW until late June.
Evento 360 (2015)

We present Evento 360 (URL: http://evento360.info), an online interactive social event browser, which allows the user to explore events detected within a web-scale multimedia corpus. The system addresses five key aspects of social multimedia event detection and summarization: multimodality, scale, diversity of representations, noise of multimedia items, and missing metadata. The detection algorithm uses unsupervised clustering approach that exploits temporal, spatial and textual metadata. For each detected event cluster, to choose the best subset of photos that meet both relevance and diversity criteria, the system uses hierarchical clustering that exploits both visual and audio information. Evento 360's user interface provides a search feature that is not limited to a certain set of events, but rather can handle an arbitrary event query. It allows the user to retrieve and explore relevant events. The system scales well and is effective in producing high-quality summaries of the detected events.
Cu2(o-Ph2PC6H4C(O)CHC(O)C(CH3)3)2: synthesis, structure and oxidation to a mixed-valent copper(I)-copper(II) complex (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCu2(o-Ph2PC6H4C(O)CHC(O)C(CH3)3)2: synthesis, structure and oxidation to a mixed-valent copper(I)-copper(II) complexDebra A. Wrobleski, Thomas B. Rauchfuss, Arnold L. Rheingold, and Keith A. LewisCite this: Inorg. Chem. 1984, 23, 20, 3124–3129Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ic00188a021https://doi.org/10.1021/ic00188a021research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Shape Changes during Through‐Mask Electrochemical Micromachining of Thin Metal Films (1992)

Shape change simulations of the electrochemical etching of lines and holes into thin metal films sandwiched between a photoresist mask and an insulating support are presented. For the moving‐boundary simulations, which use a boundary‐element method, it is assumed that the primary current distribution is applicable. The Appendix explains how formulating the current distribution problem in terms of a stream function instead of an electric potential can improve the efficiency of the numerical procedure. Two aspect ratios of photoresist thickness to cavity width are considered. In one case, large aspect ratios are assumed, and various metal film thicknesses are investigated. At long times, but before the insulating support is first exposed to the electrolyte, the shapes of the profiles can be fit to an ellipse. The simulations are continued following exposure of the support, and these results are summarized by a design curve that gives the cavity width necessary to etch a groove of a desired width or a hole of a desired radius into a metal of a given thickness. The second case that is investigated was studied experimentally by Rosset et al. [17]. The aspect ratio of this geometry is 0.08, and the thickness of the metal is large compared to the cavity width. The argeement between theory and experiment is discussed in terms of the likelihood of achieving in practical situations the modeling assumptions.
Effects of activation pattern on nonisometric human skeletal muscle performance (2007)

During volitional muscle activation, motor units often fire with varying discharge patterns that include brief, high-frequency bursts of activity. These variations in the activation rate allow the central nervous system to precisely control the forces produced by the muscle. The present study explores how varying the instantaneous frequency of stimulation pulses within a train affects nonisometric muscle performance. The peak excursion produced in response to each stimulation train was considered as the primary measure of muscle performance. The results showed that at each frequency tested between 10 and 50 Hz, variable-frequency trains that took advantage of the catchlike property of skeletal muscle produced greater excursions than constant-frequency trains. In addition, variable-frequency trains that could achieve targeted trajectories with fewer pulses than constant-frequency trains were identified. These findings suggest that similar to voluntary muscle activation patterns, varying the instantaneous frequency within a train of pulses can be used to improve muscle performance during functional electrical stimulation.
PrePeP (2018)

Pan Assays Interference Compounds (PAINS) are a significant problem in modern drug discovery: compounds showing non-target specific activity in high-throughput screening can mislead medicinal chemists during hit identification, wasting time and resources. Recent work has shown that existing structural alerts are not up to the task of identifying PAINS. To address this short-coming, we are in the process of developing a tool, PrePeP, that predicts PAINS, and allows experts to visually explore the reasons for the prediction. In the paper, we discuss the different aspects that are involved in developing a functional tool: systematically deriving structural descriptors, addressing the extreme imbalance of the data, offering visual information that pharmacological chemists are familiar with. We evaluate the quality of the approach using benchmark data sets from the literature and show that we correct several short-comings of existing PAINS alerts that have recently been pointed out.
Ellipsoidal approximations of the attraction domain in the path following problem for a wheeled robot with constrained resource (2012)

The path following problem for a wheeled robot with constrained resource moving along a given curvilinear path is studied. With the help of an earlier introduced change of variables, the path following problem is reduced to that of stability of the zero solution, and a control law linearizing the system in the case of the unconstrained control resource is synthesized. For the closed-loop system, the problem of finding the best ellipsoidal approximation of the attraction domain of the target path is set. To take into account the control constraint, an approach based on absolute stability theory is used. In the framework of this approach, construction of an approximating ellipse reduces to solving a parameterized system of linear matrix inequalities. The LMI system in the considered case can be solved analytically. Owing to this, construction of the best ellipsoidal approximation is reduced to solving a standard constrained optimization problem for a function of two variables. The proposed method is further extended to finding the best ellipsoidal approximation with an additional constraint on the maximum deviation from the target path. The discussion is illustrated by numerical examples.
An Exploratory Study of the Potential Prognostic Usefulness of the Routinely Conducted Computed Tomography Scan in Patients Hospitalized for a First Episode of Psychosis (2009)

Rationale: The clinical utility of routinely conducted computed tomography (CT) brain imaging during the evaluation of first-episode psychosis is often very limited, results typically relegated to ruling out gross intracranial pathology. Little is known about whether more commonplace findings and variants, often unreported in the radiological summary, could provide prognostic information. This study, focused on a low-income, predominantly African-American sample of public-sector, first-episode patients, addressed the understudied question of whether or not findings on routine clinical CT scans are associated with variables that may have prognostic importance. Methods: The sample included seventy-five consecutively admitted patients, aged 18-40 years, who were hospitalized for a first episode of psychosis. Sociodemographic and clinical data were obtained by a psychiatrist through a structured retrospective chart review based on dictated discharge summaries. Radiological variables were recorded by a neurora...
Multiresolution Analysis of Incomplete Rankings (2014)

Incomplete rankings on a set of items $\{1,\; \ldots,\; n\}$ are orderings of the form $a_{1}\prec\dots\prec a_{k}$, with $\{a_{1},\dots a_{k}\}\subset\{1,\dots,n\}$ and $k &lt; n$. Though they arise in many modern applications, only a few methods have been introduced to manipulate them, most of them consisting in representing any incomplete ranking by the set of all its possible linear extensions on $\{1,\; \ldots,\; n\}$. It is the major purpose of this paper to introduce a completely novel approach, which allows to treat incomplete rankings directly, representing them as injective words over $\{1,\; \ldots,\; n\}$. Unexpectedly, operations on incomplete rankings have very simple equivalents in this setting and the topological structure of the complex of injective words can be interpretated in a simple fashion from the perspective of ranking. We exploit this connection here and use recent results from algebraic topology to construct a multiresolution analysis and develop a wavelet framework for incomplete rankings. Though purely combinatorial, this construction relies on the same ideas underlying multiresolution analysis on a Euclidean space, and permits to localize the information related to rankings on each subset of items. It can be viewed as a crucial step toward nonlinear approximation of distributions of incomplete rankings and paves the way for many statistical applications, including preference data analysis and the design of recommender systems.
Seroreactivity against Streptococcal DRS (Distantly Related to SIC) Protein Is a Predictor for End-Stage Renal Failure (2008)

We hypothesized that immunoreactivity against antigens from nephritic strains of Streptococcus pyogenes may be elevated in patients with end-stage renal failure (ESRF). Additionally, we investigated whether a difference in seroreactivity exists between nonindigenous and indigenous (Aboriginal/Torres Strait Islander) patients. To examine these possibilities, antibodies against potentially nephritogenic proteins, streptokinase (Ska1) (from M1), streptococcal pyrogenic exotoxin type B (SpeB) (from M1), the streptococcal inhibitor of complement-mediated cell lysis (SIC) (from M1) and its two variants, closely related to SIC (CRS) (from M57) and distantly related to SIC (DRS) (from M12) were determined in 66 patients and 31 healthy controls by enzyme-linked immunosorbent assays. A significantly higher proportion of patients compared to controls were seropositive to Ska1 (P = 0.004), DRS (P = 0.0003), CRS (P = 0.001), and SIC (P = 0.018). Regression analysis showed that seroreactivity to DRS (r(2) = 0.85, P = 0.001) predicted the development of ESRF and that being diabetic was positively associated with being an ESRF patient (r(2) = 0.37, P < 0.0001) and being indigenous (r(2) = 0.47, P < 0.0001). These results suggest that these ESRF patients were exposed to strains of S. pyogenes that secrete Ska1, DRS, CRS, and SIC and may have pathological significance. No significant difference was observed between the indigenous patients and nonindigenous patients.