gebhart/patrepeval huggingface dataset:
Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy (2018)

Protein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation. The past few years have witnessed tremendous effort and progress in developing polymeric protein delivery nanosystems, ranging from nanoparticles, nanocapsules, nanogels, micelles, to polymersomes, for the treatment of different tumors such as lung tumors, breast tumors, ovarian cancers, and glioblastoma. These proof-of-concept studies point out that protein nanotherapeutics, with rationally designed nanovehicles, are able to overcome the extracellular barriers, cell membrane barriers, and intracellular barriers, and systemically deliver proteins into targeted cancer cells, resulting in effective cancer protein therapy. Protein nanotherapeutics appear to be a novel modality for safe and efficient cancer treatment.
The Convergence of L1/2/3 Functionality in Next Generation Network Elements – A Carrier’s Perspective (2011)

As services migrate from being primarily TDM-based to more packet-centric, it makes sense to also integrate into the transport equipment those functions that are needed to provide optimized connectivity. This presentation will focus on the rational for application-optimized transport and how this will benefit next-generation core networks.
Intramyocardial Angiomyolipoma (1994)

We report a case of cardiac angiomyolipoma in a 48-year-old woman who went to the hospital because of shortness of breath. Cardiac ultrasonography showed a right atrial mass, which was surgically removed. Pathologic examination revealed a 6-cm-diameter, dome-shaped mass composed of a mixture of blood vessels, smooth muscle, and fat. Because of its distinctive morphology and location, we diagnosed it as an intramyocardial angiomyolipoma. There was no evidence of tuberous sclerosis. Since excision of the mass, the patient has remained well without recurrence for 20 months. Angiomyolipomas usually develop in the kidney; extrarenal occurrence is rare. To date, no case of a cardiac angiomyolipoma has been reported in the English literature. The histogenesis of angiomyolipoma is uncertain, but it is most likely hamartomatous in nature.
Evolution of Hip Dysplasia in Pediatric Patients With Prader-Willi Syndrome Treated With Growth Hormone Early in Development (2019)

Level III-a retrospective comparative study.
Injectable cross‐linked collagen with improved flow properties (1989)

Aqueous suspensions of glutaraldehyde cross-linked fibrillar collagen and non-cross-linked fibrillar collagen were examined by rheometry, particle size analysis, and microscopic techniques. Although cross-linked collagen suspensions were similar to non-cross-linked suspensions by microscopic and size analyses, they differed in rheometric properties. Concentric cylinder Couette flow, shear creep, uniaxial creep, and porous bed flow all revealed that cross-linked collagen was more resistant to deformation and flow than non-cross-linked collagen. These results were in agreement with in vivo dermal implantation studies, both in pig and human; i.e., compared to non-cross-linked collagen, the cross-linked formulation was more difficult to inject into tissue and did not spread uniformly, sometimes giving rise to palpable lumps or large masses evident in histological sections. When hyaluronic acid was blended with cross-linked collagen to achieve a final hyaluronate concentration of 5 mg/mL, there was a significant improvement in ease of injection into tissue. Rheometry on blends of hyaluronate and cross-linked collagen demonstrated that the blend required lower forces to achieve deformation and flow, compared to cross-linked collagen alone. Particle size analysis on the blend showed a reduction in fiber aggregate dimensions, compared to cross-linked collagen alone.
Implication des chromosomes 1 et 7 dans la genese du cancer du sein (1994)

L'une des premieres indications de l'implication d'un gene dans les cancers est la mise en evidence, par l'analyse cytogenetique, d'anomalies chromosomiques dans les cellules tumorales. L'utilisation dans un second temps de l'analyse moleculaire, avec un grand nombre de marqueurs genetiques regulierement repartis sur les regions incriminees, permet de preciser ces regions alterees, en vue de l'identification des genes responsables du phenotype tumoral. L'objet de ce memoire est l'etude moleculaire de l'instabilite du genome dans les tumeurs du sein, en prenant pour exemple les chromosomes 1 et 7, du fait de leur fort taux d'alterations cytogenetiques. Nous avons ainsi identifie de hautes frequences d'alterations (pertes ou gains d'heterozygotie) au niveau de plusieurs regions chromosomiques, ce qui nous renseigne sur la localisation de potentiels oncogenes (1q41-q44) et genes suppresseurs (1p13-21, 1p32-pter, 1q21-31 et 7p31). De plus, nous suggerons l'existence d'un phenomene de dosage genique pour le bras long du chromosome 1 (gain ou perte de la totalite du bras). Malgre le fait que nous ayons reduites ces regions d'interet a quelques cm et exclu plusieurs genes candidats, nous n'avons pu identifier, a ce jour, les genes responsables du phenotype tumoral mammaire. Cependant, nous avons pu montrer que le potentiel gene suppresseur localise en 1p32-pter pourrait controler l'amplification des genes de la famille myc. De meme, nos resultats suggerent que l'inactivation du gene suppresseur localise en 7q31 interviendrait dans les etapes precoces de la tumorigenese mammaire. D'autre part, independamment de leur signification biologique precise, les anomalies genetiques identifiees dans les tumeurs du sein pourraient avoir un interet pronostique utilisable en cancerologie clinique. C'est le cas de la deletion du chromosome 7q31 ; les malades, dont la tumeur presente une telle alteration, ont une survie tres abaissee
Luminescence and scintillation properties of La- and La,Ag-doped CsPbCl3 single crystals (2016)

Abstract We analyzed the luminescence and scintillation properties of CsPbCl 3 single crystals. La and Ag were chosen as the dopants, although Ag proved to have little effect on the scintillation properties. In the photoluminescence spectra, in addition to the free exciton band at 425 nm, an additional band was observed at 440 nm at low temperatures for the La-doped crystals. The scintillation spectrum of the undoped crystal was composed of the free exciton band and a broad band at 600 nm, which is ascribed to lattice defects. The La doping strongly suppressed both the broad band and the slow scintillation component, which is ascribed to the emission at lattice defects.
Presynaptic actions of botulinal neurotoxins at vertebrate neuromuscular junctions. (1990)

1. In the present paper we review some presynaptic aspects of the mode of action of botulinal toxins (BoTxs) at vertebrate neuromuscular junctions with emphasis on studies carried out in our laboratories using electrophysiological and morphological techniques. 2. Spontaneous quantal transmitter release recorded as miniature end-plate potentials is drastically affected by BoTxs. The low probability of release at poisoned terminals can be enhanced by carbonyl cyanide m-chlorophenylhydrazone (CCCP), Cd2+ and La3+. However, CCCP and La3+ which drastically deplete clear synaptic vesicles from unpoisoned terminals failed to markedly affect the density of synaptic vesicles at poisoned terminals. It is concluded that poisoned terminals have a reduced sensitivity to the release-promoting action of Ca2+, Cd2+ and La3+. 3. When comparing the effect of the various BoTxs on nerve-impulse evoked transmitter release it appears that increasing phasic Ca2+ entry into the terminals enhances evoked synchronized quantal release only from terminals poisoned with serotypes A and E. In contrast, enhanced Ca2+ entry into terminals poisoned with serotypes B, D and F induced a period of high frequency asynchronous release suggesting that these BoTxs may affect a presynaptic step beyond the influx of Ca2+, that may be involved in the synchronization of transmitter quanta. These data suggest that the actions of BoTxs involve several steps of the acetylcholine release process. 4. The analysis of presynaptic currents which depend on both Ca2+ entry and intraterminal background Ca2+ levels strongly suggests that neither Ca2+ entry nor intraterminal Ca2+ levels are altered by BoTxs. Furthermore, poisoned terminals are no more efficient than unpoisoned ones in dealing with Ca2+ overloads. 5. Finally, the morphological examination of junctions paralysed by BoTx-A indicates that the toxin triggers a particularly important overgrowth of the nerve terminals and suggests that the in vivo functional recovery may occur from an extension of the original nerve terminal arborization and the concomitant remodelling of postsynaptic structures.
Static fatigue of Hi‐Nicalon™‐S fiber at elevated temperature in air, steam, and silicic acid‐saturated steam (2019)

Abstract A facility for testing SiC fiber tows in static fatigue and creep at elevated temperatures in air and steam was developed. Static fatigue of Hi‐Nicalon™‐S fibers was investigated at 800°C‐1100°C at applied stresses between 115 and 1250 MPa in air, in Si(OH) 4 (g)‐saturated steam, and in unsaturated steam. Fibers tested in Si(OH) 4 (g)‐saturated steam and in air had silica scales throughout the test sections, but those tested in unsaturated steam did not develop scales near the steam injection point. Fiber lifetimes in static fatigue were shortest in unsaturated steam, intermediate in Si(OH) 4 (g)‐saturated steam, and longest in air. Failure strains did not exceed 0.3%. Steady‐state strain rates and static fatigue lifetimes are modelled empirically by the Monkman‐Grant relationship. Failure mechanisms are discussed.
Correlación entre ancho de grieta del recubrimiento del concreto y corrosión del refuerzo en elementos expuestos a un ambiente natural contaminado por cloruros (2010)

La corrosi&amp;oacute;n del refuerzo genera da&amp;ntilde;os variados a estructuras de concreto que influyen en la capacidad de carga; entre estos da&amp;ntilde;os se puede mencionar el agrietamiento del recubrimiento del concreto. Este trabajo proporciona resultados de campo en el tema de propagaci&amp;oacute;n de grietas del recubrimiento del concreto por corrosi&amp;oacute;n del refuerzo despu&amp;eacute;s de una exposici&amp;oacute;n natural por varios a&amp;ntilde;os. Los elementos estructurales evaluados fueron una viga T y una columna cuadrada expuestos al ambiente atmosf&amp;eacute;rico de Madrid, Espa&amp;ntilde;a. Dos formulas emp&amp;iacute;ricas fueron usadas para correlacionar los valores obtenidos del agrietamiento del recubrimiento por corrosi&amp;oacute;n: w=k Px/(C/&amp;phi;), y w=k Px/Ro, en donde w es el ancho de la grieta por corrosi&amp;oacute;n, k es una constante de proporcionalidad, Px es la penetraci&amp;oacute;n por la corrosi&amp;oacute;n en el tiempo, C/&amp;phi; es la relaci&amp;oacute;n recubrimiento de concreto/di&amp;aacute;metro del refuerzo, y Ro es el radio original del refuerzo.
Optimizing the exogenous antigen loading of monocyte-derived dendritic cells (2005)

Dendritic cell (DC) vaccination, i.e. the adoptive transfer of antigen-loaded DC, is still at an early stage and requires standardization. In this study, we investigated the exogenous loading of monocyte-derived DCs with HLA class I- and II-restricted peptides, as despite widespread use, little effort has been put into its pre-clinical validation. We found that only mature DCs (m-DC) but not immature DCs (im-DC) could be sufficiently loaded with exogenous class I-restricted peptides and were by far superior in expanding CD8+ primary (Melan-A.A2 peptide-specific) and recall [Influenza matrix peptide (IMP) A2-specific] T cell responses. Primary stimulation with peptide-loaded im-DCs even down-regulated antigen-specific T cell responses. Our results indicate that stimulation with m-DCs is superior in terms of quantity and quality compared with im-DCs, supporting their preferred use in clinical DC trials. Loading of m-DCs with high (10 μM) concentrations generated clearly more Melan-A effectors than loading with 1 or 0.1 μM without any negative effect on the quality (affinity) of the resulting T cells. In contrast to the findings with the Melan-A peptide loading with 10 μM IMP was counter-productive, induced apoptosis and yielded fewer specific T cells of inferior affinity as compared with loading with 1 or 0.1 μM. In sharp contrast to the situation for HLA class I, much higher levels and longer half-lives of peptide–HLA class II complexes were obtainable upon loading of im-DCs with exogenous peptide, but m-DCs were functionally preferable to induce Th1 responses in vitro. Another surprising finding was that, while presentation to T cells upon simultaneous loading of several peptides with highly varying affinities and competing for the same class I or II molecule was possible, in priming experiments peptide competition clearly inhibited T cell induction. Although peptides will obviously vary in their individual properties, our study clearly points to some important principles that should be taken into account.
Ensuring Compliance between Policies, Requirements and Software Design: A Case Study (2006)

Specifying correct and complete access control policies is essential to secure data and ensure privacy in information systems. Traditionally, policy specification has not been an explicit part of the software development process. This isolation of policy specification from software development often results in policies that are not in compliance with system requirements and/or organizational security and privacy policies, leaving the system vulnerable to data breaches. This paper presents the results and lessons learned from a case study that employs the Requirements-based Access Control Analysis and Policy Specification (ReCAPS) method to specify access control policies for a Web-based event registration system. The ReCAPS method aids software and security engineers in specifying access control policies derived from requirements specifications and other available sources. Our case study revealed that the ReCAPS method helps identify inconsistencies across various software artifacts, such as requirements specification, database design, and organizational security and privacy policies. Had these problems not been identified and resolved, they would have crippled later phases of software development, resulted in missing or incomplete system functionality, and compromised the system's security and privacy. This case study reinforces, validates, and extends our previous recommendations that access control policy specification should be an integral part of the software development process for information systems to achieve information assurance and improve the quality of the information system
Association of ITGB3, P2RY12, and CYP2C19 gene polymorphisms with platelet functional activity in patients with coronary heart disease during dual antiplatelet therapy (2017)

The carriage of the cytochrome P450 CYP2C19 681A allele rather than platelet receptor gene polymorphisms determines a risk for clopidogrel resistance in patients with CHD.
Developing a standardized test procedure for hybrid vehicles: The challenge of the SAE HEV task force (2017)

In 1992, the Society of Automotive Engineers (SAE) established a task force to develop a procedure for measuring electric energy consumption, all-electric range, fuel economy, and exhaust emissions for hybrid vehicles; the procedure will be submitted to regulatory agencies as representing the automotive industry`s recommendations. The draft procedure is currently being tested on hybrid vehicles. The University of Maryland`s parallel hybrid was tested in September 1994, and the University of California-Davis` parallel hybrid and the University of Illinois` series hybrid will be tested in November 1994 and January 1995, respectively. The procedure is being modified to incorporate any lessons learned, and the task force hopes to recommend the final procedure to the SAE by mid 1995.
Useful Extensions of the Henry Reaction: Expeditious Routes to Nitroalkanes and Nitroalkenes in Aqueous Media (2014)

The products of the Henry nitroaldol reaction from nitromethane and several aldehydes were reduced to the corresponding nitroalkanes with (<i>n</i>-Bu)<sub>3</sub>SnH in water under microwave irradiation (80 °C/10 min), or dehydrated to the corresponding nitroalkenes with K<sub>2</sub>CO<sub>3</sub> in water (generally 0–5 °C/20 min). Both “one-pot” reactions occur in excellent yields across a range of aliphatic and aromatic (including heteroaromatic) substrates. It seems likely that the deoxygenation of the nitroaldols occurs via coordination of an oxygen atom of the nitro group with a tin atom, which facilitates hydride delivery in the transition state. The elimination of water from the nitroaldols in mild base is likely driven by the stability of the conjugated nitroalkene products. The elimination required workup with 2 N HCl, which likely displaces a nitroalkane-nitroalkene equilibrium towards the latter. These extensions of the Henry reaction lead to products not easily obtained otherwise.
Investigation of Pyrazole Compounds. IV.1 The Acylation of 3-Phenyl-5-pyrazolone and 3-Anilino-5-pyrazolone (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of Pyrazole Compounds. IV.1 The Acylation of 3-Phenyl-5-pyrazolone and 3-Anilino-5-pyrazoloneA. Weissberger and H. D. PorterCite this: J. Am. Chem. Soc. 1943, 65, 8, 1495–1502Publication Date (Print):August 1, 1943Publication History Published online1 May 2002Published inissue 1 August 1943https://pubs.acs.org/doi/10.1021/ja01248a019https://doi.org/10.1021/ja01248a019research-articleACS PublicationsRequest reuse permissionsArticle Views300Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of creatinine on various experimentally induced inflammatory models. (1979)

Creatinine, an aminoacid, has been studied for its anti-inflammatory activity. It is orally effective in suppressing the inflammatory responses produced by carrageenan, 5-hydroxytryptamine, nystatin and formaldehyde. It is observed that the antiinflammatory effect of creatinine is not owing to counter irritant action. It is suggested that it may partially be mediating its anti-inflammatory activity by interfering with the action or/and synthesis of prostaglandins. Like phenylbutazone it also possesses an analgesic action.
Exploring strain diversity of dominant human skin bacterial species using single-cell genome sequencing (2022)

To understand the role of the skin commensal bacterial community in skin health and the spread of pathogens, it is crucial to identify genetic differences in the bacterial strains corresponding to human individuals. A culture-independent genomics approach is an effective tool for obtaining massive high-quality bacterial genomes. Here we present a single-cell genome sequencing to obtain comprehensive whole-genome sequences of uncultured skin bacteria from skin swabs. We recovered 281 high-quality (HQ) and 244 medium-quality single-amplified genomes (SAGs) of multiple skin bacterial species from eight individuals, including cohabiting group. Single-cell sequencing outperformed in the genome recovery from the same skin swabs, showing 10-fold non-redundant strain genomes compared to the shotgun metagenomic sequencing and binning approach. We then focused on the abundant skin bacteria and identified intra-species diversity, especially in 47 <i>Moraxella osloensis</i> derived HQ SAGs, characterizing the strain-level heterogeneity at mobile genetic element profiles, including plasmids and prophages. Even between the cohabiting individual hosts, they have unique skin bacterial strains in the same species, which shows microdiversity in each host. Genetic and functional differences between skin bacterial strains are predictive of <i>in vivo</i> competition to adapt bacterial genome to utilize the sparse nutrients available on the skin or produce molecules that inhibit the colonization of other microbes or alter their behavior. Thus, single-cell sequencing provides a large number of genomes of higher resolution and quality than conventional metagenomic analysis and helps explore the skin commensal bacteria at the strain level, linking taxonomic and functional information.
Autonomic Factors in Hyperreactivity of Airway Smooth Muscle (1986)

The sections in this article are: 1 Sympathetic Nervous System 1.1 Sympathetic Innervation 1.2 Circulating Catecholamines 1.3 β-Receptors 1.4 α-Receptors 2 Nonadrenergic Inhibitory Nervous System 3 Parasympathetic Nervous System 3.1 General Considerations 3.2 Altered Parasympathetic Activity 3.3 Studies of Asthmatic Patients 4 conclusion4 Conclusion
Partial & Full MIMO for Orbital Angular Momentum Mode Group Division Multiplexing via Optical Fibers (2022)

The use of Orbital Angular Momentum (OAM) of light as a further degree of freedom to encode information has shown great potential in enhancing the capacity transmission and in unleashing the spectral efficiency of optical fibers. Some implications of the use of OAM in mode division multiplexing (MDM) system could degrade the scalability of the system include the complexities and the heaviness of multiple input multiple output MIMO DSP. In this paper, we discuss the MDM system incorporating OAM modes as data carriers. We focus on the employing of MIMO DSP at the receiver side of an OAM-MDM system. Our analysis shows that a small-scale MIMO DSP (i.e. partial blocks) could reduce the computational complexities and minimize the overall system complexity using either time-domain equalization (TDE) or frequency-domain equalization (FDE) approaches.
The integrated security system of the Senate of the (2009)

The security of a complex site is strongly dependent on the use of integrated technological systems. Any weakness of the integrated system involves a weakness of the security of the site itself. For this reason it is necessary to design and realize highly integrated, efficient and reliable security systems. The authors illustrate the work made to design and realize the integrated security system of the Senate of the Italian Republic.)