gebhart/patrepeval huggingface dataset:
The Treatment of Cushing's Disease (2015)

Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe endocrine disease caused by a corticotroph pituitary tumor and associated with increased morbidity and mortality. The first-line treatment for CD is pituitary surgery, which is followed by disease remission in around 78% and relapse in around 13% of patients during the 10-year period after surgery, so that nearly one third of patients experience in the long-term a failure of surgery and require an additional second-line treatment. Patients with persistent or recurrent CD require additional treatments, including pituitary radiotherapy, adrenal surgery, and/or medical therapy. Pituitary radiotherapy is effective in controlling cortisol excess in a large percentage of patients, but it is associated with a considerable risk of hypopituitarism. Adrenal surgery is followed by a rapid and definitive control of cortisol excess in nearly all patients, but it induces adrenal insufficiency. Medical therapy has recently acquired a more important role compared to the past, due to the recent employment of novel compounds able to control cortisol secretion or action. Currently, medical therapy is used as a presurgical treatment, particularly for severe disease; or as postsurgical treatment, in cases of failure or incomplete surgical tumor resection; or as bridging therapy before, during, and after radiotherapy while waiting for disease control; or, in selected cases, as primary therapy, mainly when surgery is not an option. The adrenal-directed drug ketoconazole is the most commonly used drug, mainly because of its rapid action, whereas the glucocorticoid receptor antagonist, mifepristone, is highly effective in controlling clinical comorbidities, mainly glucose intolerance, thus being a useful treatment for CD when it is associated with diabetes mellitus. Pituitary-directed drugs have the advantage of acting at the site responsible for CD, the pituitary tumor. Among this group of drugs, the dopamine agonist cabergoline and the somatostatin analog pasireotide result in disease remission in a consistent subgroup of patients with CD. Recently, pasireotide has been approved for the treatment of CD when surgery has failed or when surgery is not an option, and mifepristone has been approved for the treatment of Cushing's syndrome when associated with impairment of glucose metabolism in case of the lack of a surgical indication. Recent experience suggests that the combination of different drugs may be able to control cortisol excess in a great majority of patients with CD.
Massive distributed and parallel log analysis for organizational security (2013)

Security log analysis is extremely useful for uncovering intrusions and anomalies. However, the sheer volume of log data demands new frameworks and techniques of computing and security. We present a lightweight distributed and parallel security log analysis framework that allows organizations to analyze a massive number of system, network, and transaction logs efficiently and scalably. Different from the general distributed frameworks, e.g., MapReduce, our framework is specifically designed for security log analysis. It features a minimum set of necessary properties, such as dynamic task scheduling for streaming logs. For prototyping, we implement our framework in Amazon cloud environments (EC2 and S3) with a basic analysis application. Our evaluation demonstrates the effectiveness of our design and shows the potential of our cloud-based distributed framework in large-scale log analysis scenarios.
“Snap-Shooting” the Interface of AOT Reverse Micelles: Use of Chemical Trapping (2000)

The first use of the phenyl cation trapping technique in "snap-shooting" the local molar concentrations of water and sulfosuccinate head-groups in the interfacial region of AOT-2,2,4-trimethylpentane-water reverse micelles has been accomplished. Our results demonstrate that the interfacial concentrations of the sulfosuccinate head-groups in AOT (0.1 M)-2,2,4-trimethylpentane-water reverse micelles are remarkably high (2.75-2.34 M) across the W0 (the molar ratio of water to surfactant) range 12 to 44. However, the interfacial concentrations of water in AOT- 2,2,4-trimethylpentane-water reverse micelles across the same range of solution compositions are significantly lower (27.9-32.0 M) than the molar concentration of bulk water (55.5 M). The present results provide new insight on the microenvironments of interfacially located enzymes such as lipases entrapped in AOT-2,2,4-trimethylpentane-water reverse micelles, the most extensively exploited reverse-micellar system in micellar biotechnology.
A Case for Digital Beamforming at mmWave (2019)

Due to the heavy reliance of millimeter-wave (mmWave) wireless systems on directional links, beamforming (BF) with high-dimensional arrays is essential for cellular systems in these frequencies. Thus, performing the array processing in a power-efficient manner is a fundamental challenge. Analog and hybrid BF require few analog-to-digital and digital-to-analog converters (ADCs and DACs), but can only communicate in a small number of directions at a time, limiting directional search, spatial multiplexing, and control signaling. Digital BF enables flexible spatial processing but must be operated at a low quantization resolution to stay within reasonable power levels. This decrease in quantizer resolution distorts the received as well as the transmitted signal. To assess the effect of coarse quantization at the receiver, this paper presents a system level analytic framework based on a simple additive quantization noise model (AQNM). The analysis verified through extensive simulations reveals that at moderate resolutions (3-4 bits per ADC), there is negligible loss in downlink cellular capacity from quantization. In essence, the low resolution ADCs limit the high SNR, where cellular systems typically do not operate. For the transmitter, it is shown that DACs with 4 or more bits of resolution can support high order modulations, and do not violate the adjacent carrier leakage limit set by 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> Generation Partnership Project (3GPP) New Radio (NR) standards for cellular operations. In fact, our findings suggest that low resolution digital BF architectures can be a power-efficient alternative to analog or hybrid BF for both transmitters and receivers at millimeter-wave.
Sequential urodynamic assessment before and after laparoscopic sacrocolpopexy (2012)

The results of the study demonstrate that there are no adverse urodynamic findings following this modified technique for laparoscopic sacrocolpopexy. The statistically significant urodynamic improvements are in accordance with the scores on the Urogenital Distress Inventory questionnaires. These results do not support a simultaneous routine prophylactic colposuspension procedure.
Fabrication and Preliminary Testing of a Novel Piezoelectrically Actuated Microvalve (2003)

This paper presents the fabrication and preliminary testing of a novel piezoelectric microvalve. Fabrication has three steps, which are the actuator fabrication, valve body fabrication and assembly of the microvalve. Fabricating an actuator involves cutting piezoelectric and brass beams, gluing the brass and piezoceramic beams into a trimorph sandwich structure, and curing them under pressure at elevated temperatures. Actuators are then wired either by using conductive epoxy or soldering. Valve body parts are constructed from single crystal silicon substrates using deep reactive ion etching (DRIE). DRIE is a subtractive process, whereby a mask is created on the surface of the stock, which will shield the parts that are not to be machined. Refinements in the actuator manufacturing process are made to increase the quality and decrease the fabrication time. Using a photonic probe, tip deflections of the actuators have been tested at various temperature and voltage levels. Currently, the valves are being assembled. Once assembled, multiple microvalves will undergo cold flow testing with air followed by extensive flow extensive flow testing at elevated temperatures with humidified hydrogen.
Extending the golden hour (2015)

In the setting of severe ongoing hemorrhage, P-REBOA increased survival time beyond the golden hour while maintaining cMAP and carotid flow at physiologic levels.
A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells (2017)

Our results identify CCAT2 as a negative regulator of miRNA-145 biogenesis, and expose a novel mechanism of lncRNA-miRNA crosstalk.
The prevalence of Giardia and other intestinal parasites in children, dogs and cats from Aboriginal communities in the Kimberley (1993)

This study has shown that children from Aboriginal communities in the west Kimberley region of Western Australia, particularly in the age group one to five years, are commonly infected with intestinal parasites. The dogs and cats in these communities are also infected. The high prevalence rates of Giardia and other enteric parasites in this survey are indicative of poor living conditions and low levels of hygiene. In addition, the high prevalence of hookworm and Giardia infection in dogs and hookworm and Toxoplasma infection in cats is of potential zoonotic significance for humans in these communities.
Simultaneous Single-Shot Measurement of Two Ultrashort Pulses Using Polarization-Gating Double-Blind FROG (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. C. Wong, J. Ratner, P. Vaughan, V. Chauhan, and R. Trebino, "Simultaneous Single-Shot Measurement of Two Ultrashort Pulses Using Polarization-Gating Double-Blind FROG," in Frontiers in Optics 2011/Laser Science XXVII, OSA Technical Digest (Optica Publishing Group, 2011), paper FTuZ5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Long-term observations of macular thickness after subretinal implantation of a photovoltaic prosthesis in patients with atrophic age-related macular degeneration (2022)

<i>Objective</i>. Subretinal prostheses electrically stimulate the residual inner retinal neurons to partially restore vision. We investigated the changes in neurosensory macular structures and it is thickness associated with subretinal implantation in geographic atrophy (GA) secondary to age-related macular degeneration (AMD).<i>Approach</i>. Using optical coherence tomography, changes in distance between electrodes and retinal inner nuclear layer (INL) as well as alterations in thickness of retinal layers were measured over time above and near the subretinal chip implanted within the atrophic area. Retinal thickness (RT) was quantified across the implant surface and edges as well as outside the implant zone to compare with the natural macular changes following subretinal surgery, and the natural course of dry AMD.<i>Main results</i>. GA was defined based on complete retinal pigment epithelium and outer retinal atrophy (cRORA). Based on the analysis of three patients with subretinal implantation, we found that the distance between the implant and the target cells was stable over the long-term follow-up. Total RT above the implant decreased on average, by 39 ± 12<i>µ</i>m during 3 months post-implantation, but no significant changes were observed after that, up to 36 months of the follow-up. RT also changed near the temporal entry point areas outside the implantation zone following the surgical trauma of retinal detachment. There was no change in the macula cRORA nasal to the implanted zone, where there was no surgical trauma or manipulation.<i>Significance</i>. The surgical delivery of the photovoltaic subretinal implant causes minor RT changes that settle after 3 months, and then remain stable over long-term with no adverse structural or functional effects. Distance between the implant and the INL remains stable up to 36 months of the follow-up.
Enhanced performance of a MnO2–graphene sheet cathode for lithium ion batteries using sodium alginate as a binder (2012)

A nanoflaky MnO2–graphene sheet (GS) hybrid material was mixed with a new binder, sodium alginate, and investigated as a cathode for lithium ion batteries. The MnO2 growing on the GS afforded an unprecedented high capacity of ∼230 mA h g−1 at a large current density of 200 mA g−1, even after more than 150 cycles.
Application of the shipborne remote sensing supersite OCEANET for profiling of Arctic aerosols and clouds during Polarstern cruise PS106 (2020)

Abstract. From 25 May to 21 July 2017, the research vessel Polarstern performed the cruise PS106 to the high Arctic in the region north and northeast of Svalbard. The mobile remote-sensing platform OCEANET was deployed aboard Polarstern. Within a single container, OCEANET houses state-of-the-art remote-sensing equipment, including a multiwavelength Raman polarization lidar PollyXT and a 14-channel microwave radiometer HATPRO (Humidity And Temperature PROfiler). For the cruise PS106, the measurements were supplemented by a motion-stabilized 35 GHz cloud radar Mira-35. This paper describes the treatment of technical challenges which were immanent during the deployment of OCEANET in the high Arctic. This includes the description of the motion stabilization of the cloud radar Mira-35 to ensure vertical-pointing observations aboard the moving Polarstern as well as the applied correction of the vessels heave rate to provide valid Doppler velocities. The correction ensured a leveling accuracy of ±0.5∘ during transits through the ice and an ice floe camp. The applied heave correction reduced the signal induced by the vertical movement of the cloud radar in the PSD of the Doppler velocity by a factor of 15. Low-level clouds, in addition, frequently prevented a continuous analysis of cloud conditions from synergies of lidar and radar within Cloudnet, because the technically determined lowest detection height of Mira-35 was 165 m above sea level. To overcome this obstacle, an approach for identification of the cloud presence solely based on data from the near-field receiver of PollyXT at heights from 50 m and 165 m above sea level is presented. We found low-level stratus clouds, which were below the lowest detection range of most automatic ground-based remote-sensing instruments during 25 % of the observation time. We present case studies of aerosol and cloud studies to introduce the capabilities of the data set. In addition, new approaches for ice crystal effective radius and eddy dissipation rates from cloud radar measurements and the retrieval of aerosol optical and microphysical properties from the observations of PollyXT are introduced.
Five Lectures on Artificial Intelligence (1974)

Abstract : ;Contents: Computer systems for natural language; SHRDLU, A system for dialog; Representation, formalisms for knowledge; Frames, some ideas for a new formalism; Conceptual programming, applying artificial intelligence to program writing.
Mass ideology-based voting model (2015)

As one of the powerful tools in political science, ideal point estimation is always used to study the pattern behind the senators' voting behavior. In order to give a comprehensive estimation of senators' political positions, some researchers estimated the ideal points on different topics. However, for those senators who are not that polarized, their ideal points are so sensitive to the voting records that even a small change will make a big difference, which may mislead the readers. In this paper, we propose a mass ideology-based voting model taking the senators' latent ideology into consideration. Firstly, we model the senators' general ideal points by using the following links on Twitter due to the reason that we have homophily in social networks. Secondly, we use the roll call data of different bills, which can be decomposed as a combination of different topics, to estimate the senator's adjustment on different topics. Finally, we combine the general ideal points and the adjustments together to analyze the senator's political positions. Additionally, two-stage learning algorithms are also shown in the following section. Compared with the Issued-Adjusted model, our model has an edge on classifying the senators on different topics. This model can also be used to predict the voting behavior. Then, we show a case study of a moderate senator and try to explain her voting behavior for some bills according to our research.
Skeletal Health After Continuation, Withdrawal, or Delay of Alendronate in Men With Prostate Cancer Undergoing Androgen-Deprivation Therapy (2008)

Among men with nonmetastatic prostate cancer receiving ADT, once-weekly alendronate improves bone density and decreases turnover. A second year of alendronate provides additional skeletal benefit, whereas discontinuation results in bone loss and increased bone turnover. Delay in bisphosphonate therapy appears detrimental to bone health.
Recent developments in the assay of ferritin containing drugs. (1989)

The advent of new stationary phases for gel permeation liquid chromatography (GPLC) capable of withstanding the high pressures of high performance liquid chromatography (HPLC) has opened new avenues for the analysis of large molecules such as ferritin. The exploitation of inductively-coupled plasma atomic emission spectrometry (ICP-AES) as a technique for detection in HPLC has evolved into a significant approach to element analysis and speciation. In general, while the on-line coupling still requires careful optimization, it expediently allows the identification of proteins and the quantification of Fe in ferritin products to be achieved.
Successful in utero stem cell transplantation in X-linked severe combined immunodeficiency (2019)

Key Points IUT enables rapid immune reconstitution and avoids many clinical and economic problems; however, the indication is still limited. IUT may be a treatment option in select cases, eg, fetuses exposed to a significant infectious risk, where a matched sibling donor exists.
Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation (2021)

Site-specific conjugation to cysteines of proteins often uses ester groups to link maleimide or alkene groups to polymers. However, the ester group is susceptible to hydrolysis, potentially losing the benefits gained through bioconjugation. Here, we present a simple conjugation strategy that utilizes the amide bond stability of traditional 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide coupling while introducing site specificity. Hydrolytically stable maleimide-end-functionalized polymers for site-specific conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain-transfer (RAFT) polymerization. The alpha terminus of the polymers was amidated with a furan-protected aminoethyl maleimide using carbodiimide-based chemistry. Finally, the maleimide was exposed by a retro Diels-Alder reaction to yield the maleimide group, allowing for thiol-maleimide click chemistry for bioconjugation. A thermophilic cellulase from <i>Fervidobacterium nodosum</i> (<i>Fn</i>Cel5a) was conjugated using various strategies, including random 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) coupling, site-specific hydroxyethyl maleimide (HEMI) end-functionalized coupling, hydroxyethyl acrylate (HEA) end-functionalized coupling, and amidoethyl maleimide (AEMI) end-functionalized coupling. Only the polymers conjugated by EDC and AEMI remained conjugated a week after attachment. This indicates that hydrolytically stable amide-based maleimides are an important bioconjugation strategy for conjugates that require long-term stability, while esters are better suited for systems that require debonding of polymers over time.
The role of orthodontic extrusive remodeling in the enhancement of soft and hard tissue profiles prior to implant placement: a systematic approach to the management of extraction site defects. (1993)

A classification scheme that systematizes the wide range of regenerative potential of common extraction site topographies is presented. Within this system, the parameters for immediate implant placement and preliminary ridge augmentation are discussed. In addition, a new adjunctive role for orthodontic extrusion is introduced. This approach is intended to manipulate "hopeless" teeth to modify their local defect environments, thereby enhancing the predictability of subsequent implant placement at those sites.
A Prospective Study on Safety, Complications and Satisfaction Analysis for Tear Trough Rejuvenation Using Hyaluronic Acid Dermal Fillers (2020)

TT treatment, if performed using a cannula with a maximum of 1ml used in one sitting between both eyes, according to this study, is a safe treatment with a very low pain rating and with no major complications and high patient satisfaction.
Retrieving and visualizing video (1997)

article Free AccessRetrieving and visualizing video Authors: Boon-Lock Yeo the manager of the, Visual Computing and Communications Department of the IBM, Thomas J.Watson Research Center in Yorktown Heights, N.Y. the manager of the, Visual Computing and Communications Department of the IBM, Thomas J.Watson Research Center in Yorktown Heights, N.Y.View Profile , Minerva M. Yeung research staff, member in the Image Library Applications department of the IBM, Thomas J.Watson Research Center in Yorktown Heights, N.Y. research staff, member in the Image Library Applications department of the IBM, Thomas J.Watson Research Center in Yorktown Heights, N.Y.View Profile Authors Info & Claims Communications of the ACMVolume 40Issue 12Dec. 1997 pp 43–52https://doi.org/10.1145/265563.265571Published:01 December 1997Publication History 58citation1,297DownloadsMetricsTotal Citations58Total Downloads1,297Last 12 Months36Last 6 weeks20 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF