gebhart/patrepeval huggingface dataset:
An embedded artificial skin for humanoid robots (2008)

A novel artificial skin for covering the whole body of a humanoid robot is presented. It provides pressure measurements and shape information about the contact surfaces between the robot and the environment. The system is based on a mesh of sensors interconnected in order to form a networked structure. Each sensor has 12 capacitive taxels, has a triangular shape and is supported by a flexible substrate in order to conform to smooth curved surfaces. Three communications ports placed along the sides of each sensor sides allow communications with adjacent sensors. The tactile measurements are sent to embed microcontroller boards using serial bus communication links. The system can adaptively reduce its spatial resolution, improving the response time. This feature is very useful for detecting the first contact very rapidly, at a lower spatial resolution, and then increase the spatial resolution in the region of contact for accurate reconstruction of the contact pressure distribution.
Water budget-salt balance model for calculating net water saving considering different non-conventional water resources in agricultural process (2023)

Iraq is facing a dire water crisis due to the decrease in water quantities flow in Tigris and Euphrates Rivers. Due to population growth, several studies estimated the water shortage in 2035 to be 44 Billion Cubic Meter (BCM). Thus, Water Budget-Salt Balance Model (WBSBM) has been developed, applied and examined for the Euphrates River basin to compute the net water saving from Non-Conventional Water Resources (NCWRs). WBSBM includes 4-stages; the first is to identify the required data correspond to the conventional water resources in the study-area. The second stage is demonstrating the water-users activities. Thirdly, develop model through the proposed NCWR projects that reflect the required data. The final stage involves net water saving computation while applying all the NCWR projects simultaneously. The results obtained the optimal potential net water saving amount, which are 6.823 and 6.626 BCM/year in 2025 and 2035, respectively. In conclusion, the proposed WBSBM model has comprehensively examined different scenarios of utilizing NCWRs and has determined the optimal potential the net water saving amounts.
Recognizing entities across protocols with unified UUID discovery and asymmetric keys (2013)

The Internet-of-Things vision introduces scenarios composed of many devices and protocols, in order to support real world user interactions. This also brought a fractured vision, since it is hard to extend communication over diverse technologies, even for communication with the same devices. In this paper we propose to address the fractured loT ecosystem using a UUID based discovery layer that allows recognising entities across different protocols. By using asymmetric keys as the basis for a UUID device identification namespace, we provide a stable identification layer that enables recognizing entities (devices) across protocols and simultaneously retaining a security context over different protocols. We use this identification and discovery layer as the basis for an integrated framework where communication between devices can happen over any available channel or technology. The framework is instantiated in an experimental prototype, used to assess the pragmatic changes and overall impact of using a cross-protocol identification scheme.
Mouse F9 teratocarcinoma stem cells expressing the stably transfected homeobox gene Hox 1.6 exhibit an altered morphology. (1992)

Expression of the murine homeobox gene Hox 1.6 rapidly increases in F9 teratocarcinoma cells when these cells are induced with retinoic acid to differentiate into primitive and parietal endoderm. Hox 1.6 encodes a putative transcriptional regulatory protein which may function as a secondary regulator of gene expression during the differentiation process. To examine the role of the Hox 1.6 gene, we have stably transfected F9 stem cells with a cDNA containing the complete coding sequence of Hox 1.6 under the control of the mouse metallothionein promoter. Two clonally distinct cell lines that express high levels of the transfected Hox 1.6 gene have been isolated and characterized. We show that expression of the transfected Hox 1.6 gene in F9 cells dramatically alters the stem cell morphology. However, the transfected cells do not differentiate in the absence of retinoic acid treatment, nor are they prevented from differentiating in response to such treatments. We therefore suggest that the Hox 1.6 gene controls the expression of genes which influence changes in F9 cell morphology during RA-induced differentiation.
Simeprevir plus sofosbuvir in patients with chronic hepatitis C virus genotype 1 infection and cirrhosis: A phase 3 study (OPTIMIST‐2) (2015)

Simeprevir + sofosbuvir for 12 weeks achieved superiority in SVR12 rates versus the historical control in treatment-naive and treatment-experienced HCV GT1-infected patients with cirrhosis and was generally safe and well tolerated. (Hepatology 2016;64:360-369).
Diels‐alder reactions of cyclohexadienes derived from decarboxylation of photo[4 + 2]cycloadducts between 4,6‐dimethyl‐2‐pyrone and cyclic olefins (1991)

Abstract Labile photo [4 + 2] adducts between 4,6‐dimethyl‐2‐pyrone and cyclic olefins reacted with second olefins to give cross adducts, and with acetylenes to afford both bis‐adducts and benzene derivatives with the concurrent decarboxylation, respectively. The reaction mechanism of the latter was considered.
Crystallization of Membrane Proteins in Lipidic Mesophases (2011)

Membrane proteins perform critical functions in living cells related to signal transduction, transport and energy transformations, and, as such, are implicated in a multitude of malfunctions and diseases. However, a structural and functional understanding of membrane proteins is strongly lagging behind that of their soluble partners, mainly, due to difficulties associated with their solubilization and generation of diffraction quality crystals. Crystallization in lipidic mesophases (also known as in meso or LCP crystallization) is a promising technique which was successfully applied to obtain high resolution structures of microbial rhodopsins, photosynthetic proteins, outer membrane beta barrels and G protein-coupled receptors. In meso crystallization takes advantage of a native-like membrane environment and typically produces crystals with lower solvent content and better ordering as compared to traditional crystallization from detergent solutions. The method is not difficult, but requires an understanding of lipid phase behavior and practice in handling viscous mesophase materials. Here we demonstrate a simple and efficient way of making LCP and reconstituting a membrane protein in the lipid bilayer of LCP using a syringe mixer, followed by dispensing nanoliter portions of LCP into an assay or crystallization plate, conducting pre-crystallization assays and harvesting crystals from the LCP matrix. These protocols provide a basic guide for approaching in meso crystallization trials; however, as with any crystallization experiment, extensive screening and optimization are required, and a successful outcome is not necessarily guaranteed.
Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores (2004)

The replication timing of some genes is developmentally regulated, but the significance of replication timing to cellular differentiation has been difficult to substantiate. Studies have largely been restricted to the comparison of a few genes in established cell lines derived from different tissues, and most of these genes do not change replication timing. Hence, it has not been possible to predict how many or what types of genes might be subject to such control. Here, we have evaluated the replication timing of 54 tissue-specific genes in mouse embryonic stem cells before and after differentiation to neural precursors. Strikingly, genes residing within isochores rich in GC and poor in long interspersed nuclear elements (LINEs) did not change their replication timing, whereas half of genes within isochores rich in AT and long interspersed nuclear elements displayed programmed changes in replication timing that accompanied changes in gene expression. Our results provide direct evidence that differentiation-induced autosomal replication-timing changes are a significant part of mammalian development, provide a means to predict genes subject to such regulation, and suggest that replication timing may be more related to the evolution of metazoan genomes than to gene function or expression pattern.
CKD Accelerates Development of Neointimal Hyperplasia in Arteriovenous Fistulas (2009)

Arteriovenous (AV) access failure resulting from venous neointimal hyperplasia is a major cause of morbidity in patients with ESRD. To understand the role of chronic kidney disease (CKD) in the development of neointimal hyperplasia, we created AV fistulae (common carotid artery to jugular vein in an end-to-side anastomosis) in mice with or without CKD (renal ablation or sham operation). At 2 and 3 wk after operation, neointimal hyperplasia at the site of the AV anastomosis increased 2-fold in animals with CKD compared with controls, but cellular proliferation in the neointimal hyperplastic lesions did not significantly differ between the groups, suggesting that the enhanced neointimal hyperplasia in the setting of CKD may be secondary to a migratory phenotype of vascular smooth muscle cells (VSMC). In ex vivo migration assays, aortic VSMC harvested from mice with CKD migrated significantly greater than VSMC harvested from control mice. Moreover, animals with CKD had higher serum levels of osteopontin, which stimulates VSMC migration. When we treated animals with bone morphogenic protein-7, which promotes VSMC differentiation, before creation of the AV anastomosis, the effect of CKD on the development of neointimal hyperplasia was eliminated. In summary, CKD accelerates development of neointimal hyperplasia at the anastomotic site of an AV fistula, and administration of bone morphogenic protein-7 neutralizes this effect.
Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: A narrative literature review (2016)

Sexual dysfunction is an underdiscussed adverse effect to selective serotonin reuptake inhibitors (SSRIs) and may increase the risk for discontinuation and nonadherence to antidepressant pharmacotherapy. Given the prevalence of depression, health care providers should educate patients about SSRI-associated sexual dysfunction in order to promote patient awareness and medication adherence. This study evaluated primary literature from 1997 to 2015 to identify SSRI-related sexual side effects, therapeutic alternatives, and treatment strategies. The results indicate that paroxetine is associated with the greatest rate of sexual dysfunction among the SSRIs. Potential alternatives to SSRI treatment include bupropion, mirtazapine, vilazodone, vortioxetine, and serotonin-norepinephrine reuptake inhibitors. In the event that a subject responds solely to SSRIs but experiences unwanted sexual side effects, bupropion may be added as an adjunctive medication. Some limited evidence also suggests that saffron may reduce some aspects of sexual dysfunction, excluding ability to reach orgasm.
Fractures at the base of the thumb (1979)

Oblique traction on the thumb metacarpal, originally described for the treatment of Bennett's fracture, has been applied to comminuted intra-articular fractures of the thumb metacarpal to counter the forces that cause shortening and varus angulation. It also has been applied to fractures of the trapezium to restore congruity of the trapeziometacarpal joint. It was successful in achieving and maintaining a satisfactory reduction in eight patients with these three types of fractures.
Sonolysis of chlorobenzene in the presence of transition metal salts (2003)

Abstract Sonolysis of aqueous solution of chlorobenzene at 200 kHz frequency in the presence of transition metals chlorides was investigated. Through analyzing the nature and distribution of the products detected in the reaction mixture, a new mechanism of sonodegradation is advanced. Depending on the metals used and their behavior during sonolysis, we were able to discriminate between inside and outside cavitation bubble mechanisms. Iron and cobalt chlorides, which could undergo redox reactions in the presence of HO radicals generated ultrasonically, give higher amounts of phenolic compounds compared with palladium chloride that undergoes a reduction to metal. Palladium reduction takes place in bulk solution and therefore all organic reactions that compete for hydrogen must occur also in bulk solution. Accordingly, palladium can be a useful tool in determining the reaction site and the decomposition mechanism of organic compounds under ultrasonic irradiation.
Leukemia-Associated Fusion Proteins: Multiple Mechanisms of Action to Drive Cell Transformation (2004)

Leukemic cells are defined by two main biological features: arrest of differentiation at a specific stage compatible with continued proliferation, and enhanced resistance to stress. Recent work shows that the leukemia-associated fusion protein PML-RAR can mediate both biological effects targeting independent pathways, through a unifying mechanism. Differentiation block is achieved through transcriptional silencing of genes physiologically regulated by RAR, which are involved in hematopoietic differentiation. In contrast, enhanced resistance to stress is due to the capacity of the fusion protein to cause degradation of the tumor suppressor p53, thus explaining the puzzling observation that mutations of p53 are remarkably rare in acute myeloid leukemias (AMLs). Interestingly, this latter phenomenon depends on expression of wild-type PML, acting as a molecular bridge between p53 and the fusion protein. Strikingly, both effects require a unifying molecular mechanism: aberrant recruitment of histone deacetylases (HDACs). Therefore, the study of this form of leukemia appears also of interest for a better understanding of the action of HDAC inhibitors, potential antitumor drugs that are at the early stages of clinical studies.
Energy Utilization as Affected by Traffic in a Conventional and Conservation Tillage System (1994)

The increased emphasis on conservation tillage, as a result of the compliance guidelines in the 1985 and 1990 Farm Bills, causes mechanical energy utilization to play an important role in the choice of systems for managing soil compaction. Therefore, a study was conducted to determine the effects of traffic and tillage systems on the energy required to establish a cotton (Gossypium hirsutum L.) crop. Traffic treatments included no-traffic and a conventional traffic system. Tillage treatments included disking and field cultivation, both with and without subsoiling, and a conservation tillage treatment (strip-tillage) which involved only subsoiling and planting into wheat (Triticum aestivum L.) residue/stubble over the subsoiled slot. Results showed that traffic had no effect on the energy required for crop establishment. Results also showed that tillage treatment had an important effect on the mechanical energy required for crop establishment. The strip-tillage system required less energy than all other treatments.
NCI-EORTC--10th Symposium--new approaches and cellular targets. 16-19 June 1998, Amsterdam, The Netherlands. (1998)

This meeting was the tenth in a series dating back 20 years. The symposium provided a forum for the presentation and discussion of recent results on the preclinical and early clinical R and D of new anticancer agents. Reflecting the current opinions in anticancer drug development, there was a much greater emphasis on new biological/molecular-based therapies in comparison to the greater proportion of cytotoxic agents at earlier meetings. Reflecting the current general thinking of new anticancer drug development, a keynote session was dedicated to new approaches and cellular targets. These included telomerase, apoptosis and p53, although in some cases, the targets did not appear particularly new.
Salvage Surgery in Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (2023)

Abstract Background In patients with stage IIIB, stage IIIC and stage IV non-small cell lung cancer (NSCLC), guidelines generally recommend systemic therapy with or without radiotherapy. Despite this treatment, complete response remains rare. However, in a selected group of patients with either residual disease after partial response to first-line systemic treatment, or oligo-recurrence, surgical resection within a salvage concept is under evaluation as an additional treatment option. Currently, clinical data on the outcome of this approach are scarce. Aims We aimed to assess short- and long-term outcomes of salvage surgery in advanced NSCLC. Methods We retrospectively identified 35 patients with initial stage IIIB, IIIC, or IV NSCLC who underwent anatomical lung resection to treat local relapse or residual disease. All patients had initially received systemic treatment with or without radiotherapy. Patients were only included if surgical resection had not been part of the first-line treatment approach. Results Among 35 patients (54% male, mean age 60.2±10.9 years), the initial clinical UICC stage was IIIB in 4, IIIC in 4, IVA in 22, and IVB in 5 cases. The indication for salvage resection was residual disease after first-line treatment in 21 cases and local relapse in 14 cases. Anatomical lung resections included 22 lobectomies, 11 pneumonectomies, 1 bilobectomy and 1 segmentectomy. R0-resection was achieved in 94.3% and pathological complete response was found in 22.9% of all resections. 30-and 90-day mortality were 0% and 11.4%, respectively. mOS and progression-free-survival (calculated from the date of salvage surgery) of the entire cohort were 69 months [95% CI 37–101 months] and 22 months [95% CI: 0–45 months] respectively. Conclusions In selected patients with advanced stage NSCLC presenting with local relapse or residual disease after systemic treatment, anatomical salvage lung resections are associated with a favorable short- and long-term outcome. However, further prospective evaluation of this treatment approach is required.
Magnetron sputter-deposited multilayer (BaxSr1x)Ti1+yO3+zthin films for passive and active devices (2001)

Abstract High permittivity (BaxSr1−x)Ti1+yO3+z(BST) thin films are being investigated for integration into charge storage dielectrics and electric-field tunable elements for high frequency devices. For the latter application, it is desirable to have BST capacitors with high tunability and low losses. Therefore, we investigated the use of multilayer BST thin films consisting of very low dielectric loss BST/electrode interfacial layers ((Ba+Sr)/Ti = 0.73) sandwiching a high tunability, high permittivity primary BST layer ((Ba+Sr)/Ti = 0.9). BST capacitors with multiple layers of controlled composition can be effectively produced insitu by magnetron sputter deposition, using a single stoichiometric target and controlling the layer composition by changing the total process gas (Ar+O<2) pressure. The layered BST film capacitors exhibit simultaneous low loss (tan Δ = 0.005), high tunability (76%), high charge storage energy density (34 J/cm3), low leakage, and high dielectric breakdown (>2.8 MV/cm).
Optimal design of multipurpose batch plants. 2. A decomposition solution strategy (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimal design of multipurpose batch plants. 2. A decomposition solution strategySavoula Papageorgaki and Gintaras V. ReklaitisCite this: Ind. Eng. Chem. Res. 1990, 29, 10, 2062–2073Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ie00106a014https://doi.org/10.1021/ie00106a014research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cranial Sutures: A Brief Review (2008)

Craniosynostosis, or the premature fusion of one or more cranial sutures, is a relatively common congenital defect that causes a number of morphologic and functional abnormalities. With advances in genetics and molecular biology, research of craniosynostosis has progressed from describing gross abnormalities to understanding the molecular interactions that underlie these cranial deformities. Animal models have been extremely valuable in improving our comprehension of human craniofacial morphogenesis, primarily by human genetic linkage analysis and the development of knock-out animals. This article provides a brief review of perisutural tissue interactions, embryonic origins, signaling molecules and their receptors, and transcription factors in maintaining the delicate balance between proliferation and differentiation of cells within the suture complex that determines suture fate. Finally, this article discusses the potential implications for developing novel therapies for craniosynostosis.
One-electron redox potentials of phenols. Hydroxy- and aminophenols and related compounds of biological interest (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOne-electron redox potentials of phenols. Hydroxy- and aminophenols and related compounds of biological interestS. Steenken and P. NetaCite this: J. Phys. Chem. 1982, 86, 18, 3661–3667Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://doi.org/10.1021/j100215a033RIGHTS & PERMISSIONSArticle Views3788Altmetric-Citations357LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (793 KB) Get e-Alerts