gebhart/patrepeval huggingface dataset:
Filtering competing messages to enhance mutual intelligibility (1986)

Filtering simultaneous messages into different frequency bands prior to summation and presentation to a single ear was examined as an aid to message reception. Two or four concurrent sentences spoken by different talkers were presented through a single earphone to normal-hearing subjects. Listeners were instructed to write down the message spoken by the target talker, whose voice was indicated by an isolated lead-in message. In the reference condition, the wideband (0–4.5 kHz) sentences were simply summed; in various test conditions, the sentences were passed separately through different filters and then summed. Average intelligibility of the filtered sentences in the two-message task did not exceed that of the reference condition for any scheme tested. In the four-message task, however, performance improved significantly for three of five filtering configurations evaluated, the best of which resulted in 39% correct overall intelligibility compared to approximately 22% correct in the reference condition. Such a filtering scheme may be beneficial in future hearing aids that present multiple directional channels to a single ear. [Work supported by NIH.]
Application of the method of moments for the modelling of the enzymatic hydrolysis of cellulosic substrates (2015)

International audience
[Antianoxic effects of Dracocephalum tanguticum on brain of mice]. (1997)

The aqueous extracts i.p. of Dracocephalum tanguticum Maxim (DtM), a Tibetan medicine, prolong sighificantly decapitaion-induced gasping duration in mice and the survival time of mice ligated bilateral carotid (P > 0.01). DtM prolong also the primal gasping in mice after injecting the air into the coccygeal vein (P > 0.01) and the survival time in mice poisoned by Lidocaine (P > 0.05). In addition, DtM is possessed of protecting against the pathologic lession of brain in rats under stimulating high altitude hypoxic condition. The results suggest that DtM has a antianoxic effects on mice.
3D perfusion bioreactor‐activated porous granules on implant fixation and early bone formation in sheep (2016)

Early fixation of total joint arthroplasties is crucial for ensuring implant survival. An alternative bone graft material in revision surgery is needed to replace the current gold standard, allograft, seeing that the latter is associated with several disadvantages. The incubation of such a construct in a perfusion bioreactor has been shown to produce viable bone graft materials. This study aimed at producing larger amounts of viable bone graft material (hydroxyapatite 70% and β-tricalcium-phosphate 30%) in a novel perfusion bioreactor. The abilities of the bioreactor-activated graft material to induce early implant fixation were tested in a bilateral implant defect model in sheep, with allograft as the control group. Defects were bilaterally created in the distal femurs of the animals, and titanium implants were inserted. The concentric gaps around the implants were randomly filled with either allograft, granules, granules with bone marrow aspirate or bioreactor-activated graft material. Following an observation time of 6 weeks, early implant fixation and bone formation were assessed by micro-CT scanning, mechanical testing, and histomorphometry. Bone formations were seen in all groups, while no significant differences between groups were found regarding early implant fixation. The microarchitecture of the bone formed by the synthetic graft materials resembled that of allograft. Histomorphometry revealed that allograft induced significantly more bone and less fibrous tissue (p < 0.05). In conclusion, bone formation was observed in all groups, while the bioreactor-activated graft material did not reveal additional effects on early implant fixation comparable to allograft in this model. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2465-2476, 2017.
A Spectrophotometric Study of the Complex Formation between Iron(III) and Sulfosalicylic Acid (1966)

Abstract A spectrophotometric study of the complex formation between iron(III) and sulfosalicylic acid was carried out over the pH range up to 8; further, an attempt was made to test the applicability of sulfosalicylic acid as a reagent for the spectrophotometric determination of iron(III) in the presence of iron(II). The absorption maxima are found at 510 mμ independently of the pH between 1 to 2.5, while they shift in the direction of shorter wavelength as the pH rises. It was concluded that three complex species, Fe(Su), Fe(Su)23−, and Fe(Su)36−, are formed successively in acid solutions; their stability constants were determined to be: (Remark: Graphics omitted.) where Su3− denotes the sulfosalicylate anion, C6H3(O−)(COO−)(SO3−). If the pH of the solution is adjusted from 3 to 4.5 and if the absorbancy measurements are made at 480 to 490 mμ, sulfosalicylic acid can be used as a reagent for determining iron(III) in the presence of iron(II). The optimum concentration of iron(III) is 2 to 10 p. p. m.; iron(II) does not interfere, even at a concentration of 100 p. p. m.
Constructive polarization modulation for coherent population trapping clock (2014)

We propose a constructive polarization modulation scheme for atomic clocks based on coherent population trapping (CPT). In this scheme, the polarization of a bichromatic laser beam is modulated between two opposite circular polarizations to avoid trapping the atomic populations in the extreme Zeeman sublevels. We show that if an appropriate phase modulation between the two optical components of the bichromatic laser is applied synchronously, the two CPT dark states which are produced successively by the alternate polarizations add constructively. Measured CPT resonance contrasts up to 20% in one-pulse CPT and 12% in two-pulse Ramsey-CPT experiments are reported, demonstrating the potential of this scheme for applications to high performance atomic clocks.
Directionally classified eigenblocks for localized feature analysis in face recognition (2006)

A new local feature extraction method is introduced. The directionality of local facial regions is regarded as essential information for discriminating faces in our approach, which is motivated by the directional selectivity of the Gabor wavelet transformation, which has been preferred to others for face recognition. The discriminative directional information is forced to be compacted in a few coefficients by applying principle-component analysis with the support of directional classification in the discrete cosine transform domain. The local features extracted by our method are better at discriminating face patterns than previous ones, as was verified by comparison of class-separability results. Also, in face recognition simulations using rigid and flexible face matching strategies based on locally extracted features, our proposed method showed outstanding performance.
Mesoporous carbons prepared by nano-casting with meso- or non-porous silica nanoparticles (2006)

Mesoporous carbons were obtained by sequential nano-casting using the following hard templates: (i) mesoporous silica nanospheres with MCM-41 or MCM-48 analogous structure; (ii) non-porous silica nanospheres and (iii) pyrogenic silica (Aerosil 200). These silica templates (patrix) were impregnated with sucrose, carbonized at 800 ºC under nitrogen atmosphere and finally the silica dissolved with hydrofluoric acid. It was observed that the specific surface area of the carbon matrixes can be enhanced reducing the diameter of the silica nanospheres or the distance between them by agglomeration prior to the impregnation of the silica patrix with sucrose. Mesoporous carbons with specific surface areas higher than 500 m² g-1 were obtained using mesoporous silica spheres. In this case, the carbon matrixes contain mesopores with a narrow pore size distribution and with diameters in the order of the wall thickness of the mesoporous silica used as hard template.
Natural Bactericidal Surfaces: Mechanical Rupture of Pseudomonas aeruginosa Cells by Cicada Wings (2012)

Natural superhydrophobic surfaces are often thought to have antibiofouling potential due to their self-cleaning properties. However, when incubated on cicada wings, Pseudomonas aeruginosa cells are not repelled; instead they are penetrated by the nanopillar arrays present on the wing surface, resulting in bacterial cell death. Cicada wings are effective antibacterial, as opposed to antibiofouling, surfaces.
Process optimization and diffusion length evaluation of a new aqueous base developable negative epoxy electron beam resist (2002)

A new aqueous base developable, chemically amplified negative resist based on epoxy chemistry (ADEPR) is evaluated for high resolution, high-speed e-beam lithography. The acid diffusion coefficient of this system is also evaluated. This resist is formulated using partially hydrogenated poly(hydroxy styrene) and epoxy novolac polymers. The absence of swelling phenomena compared to pure epoxy systems allows lithography up to 100 nm regime and a sensitivity of 4-8 /spl mu/C/cm/sup 2/ at 50 KeV. Both high-resolution line and dot exposures were used in order to evaluate the diffusion coefficient. The value of D=5.10/sup -14/ cm/sup 2//sec fount is a little higher than its pure epoxy counterpart (EPR) but still lower than other commercial resists.
A perfect hashing incremental scheme for unranked trees using pseudo-minimal automata (2009)

We describe a technique that maps unranked trees to arbitrary hash codes using a bottom-up deterministic tree automaton (DTA). In contrast to other hashing techniques based on automata, our procedure builds a pseudo-minimal DTA for this purpose. A pseudo-minimal automaton may be larger than the minimal one accepting the same language but, in turn, it contains proper elements (states or transitions which are unique) for every input accepted by the automaton. Therefore, pseudo-minimal DTA are a suitable structure to implement stable hashing schemes, that is, schemes where the output for every key can be determined prior to the automaton construction. We provide incremental procedures to build the pseudo-minimal DTA and the mapping that associates an integer value to every transition that will be used to compute the hash codes. This incremental construction allows for the incorporation of new trees and their hash codes without the need to rebuild the whole DTA from scratch.
Cascaded Channel Estimation for Intelligent Reflecting Surface Assisted Multiuser MISO Systems (2021)

This paper investigates the uplink cascaded channel estimation for intelligent-reflecting-surface (IRS)-assisted multi-user multiple-input-single-output systems. We focus on a sub-6 GHz scenario where the channel propagation is not sparse and the number of IRS elements can be larger than the number of BS antennas. A novel channel estimation protocol without the need of on-off amplitude control to avoid the reflection power loss is proposed. In addition, the pilot overhead is substantially reduced by exploiting the common-link structure to decompose the cascaded channel coefficients by the multiplication of the common-link variables and the user-specific variables. However, these two types of variables are highly coupled, which makes them difficult to estimate. To address this issue, we formulate an optimization-based joint channel estimation problem, which only utilizes the covariance of the cascaded channel. Then, we design a low-complexity alternating optimization algorithm with efficient initialization for the non-convex optimization problem, which achieves a local optimum solution. To further enhance the estimation accuracy, we propose a new formulation to optimize the training phase shifting configuration for the proposed protocol, and then solve it using the successive convex approximation algorithm. Comprehensive simulations verify that the proposed algorithm has supreme performance compared to various state-of-the-art baseline schemes.
Trafficking of QD‐Conjugated MPO‐ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice (2007)

Abstract In systemic vasculitis, the serum level of myeloperoxidase (MPO)‐specific anti‐neutrophil cytoplasmic autoantibodies (MPO‐ANCA) is significantly elevated with the progression of disease. We have established a model of murine systemic vasculitis by administration of MPO‐ANCA and fungal mannoprotein to C57BL/6 mice. We examined the role of MPO and MPO‐ANCA in the pathogenesis of glomerulonephritis and systemic vasculitis in this model using quantum dots (QDs). We demonstrated that QD‐conjugated MPO‐ANCA (ANCA‐QD) visualized the translocation of MPO on the neutrophil membrane surface after stimulation with proinflammatory cytokines. We also observed that MPO translocation on neutrophils in both patients with rapid progressive glomerulonephritis and these model mice without any stimulation, suggesting that MPO translocation is certain to contribute to the development of glomerular lesion. In addition, blood flow on the kidney surface vessel was significantly decelerated in both SCG/Kj mice and this model, suggesting that ANCA induces the damage of blood vessel. These results indicate that MPO‐ANCA and surface‐translocated MPO on the activated neutrophils coordinately plays essential roles in the initial steps of the glomerulonephritis.
ANTI-OVULATORY AND OTHER BIOLOGICAL PROPERTIES OF MEGESTROL ACETATE 17αACETOXY-6 METHYL PREGNA 4:6-DIENE-3:20-DIONE (B.D.H. 1298) (1963)

Summary. 17αAcetoxy-6 methyl pregna 4:6-diene-3:20-dione (B.D.H. 1298), has been given the approved name of Megestrol acetate. It appears to be the most potent anti-ovulatory compound so far reported. It also possesses high oral progestational properties, being more active in the Clauberg assay than medroxy progesterone acetate, commercial norethynodrel and dimethisterone given orally, and progesterone subcutaneously. It is non-toxic in mice; prolonged administration to rats caused no adverse effects except at high doses in females where some adrenal atrophy was observed. It has no anabolic, androgenic or oestrogenic properties and no virilizing effect on the developing foetus.
A 256K HCMOS ROM using a four-state cell approach (1985)

A 256K HCMOS ROM design is discussed using a geometry-variable four-state cell for high packing density. Design, area, and process margin comparisons are made to other cell approaches. The architecture of the chip is shown and device performance is summarized. The 32K/spl times/8-bit ROM has typical access times of 200 ns with 11 mA of active current at 1000-ns cycle times and typical standby currents of 300 nA. Single-layer programming is performed with the poly layer, which is in the later stages of the process cycle than field-oxide or depletion implant programmed parts. The part is produced using an n-well HCMOS process with 2-/spl mu/m poly gate lengths. The part exhibits immunity from latchup without an epi substrate layer. This is primarily due to layout procedures to insure good substrate clamping and guardbanding.
Percutaneous Coronary Intervention vs Thrombolysis for ST-Elevation Myocardial Infarction (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gerinnungshemmende Wirkstoffe blutsaugender Tiere: von Hirudin zu Hirudinmimetica (1995)

Abstract Blutsaugende Tiere enthalten in ihrem Speichel Substanzen, die gezielt in das System der Blutgerinnung des Wirts eingreifen. Bei diesen Wirkstoffen handelt es sich zumeist um niedermolekulare Proteine mit Molekülmassen zwischen 4 und 50 kDa. Einige sind heute mit Hilfe von gentechnologischen Methoden in großer Menge zugänglich, so daß ihre Struktur und die Struktur‐Wirkungs‐Beziehungen untersucht und sie klinisch erprobt werden können. In Kenntnis der Wirkungsweise solcher Naturstoffe auf molekularer Ebene lassen sich neue Substanzen mit möglicher therapeutischer Wirkung ableiten. Diese Vorgehensweise wurde in den letzten zehn Jahren an dem Proteinaseinhibitor Hirudin aus medizinischen Blutegeln und dem Thrombin/Hirudin‐Komplex getestet. Die Serinprotease Thrombin spielt eine zentrale Rolle bei der komplex verlaufenden Blutgerinnung, und ihre pathophysiologische Wirkung ist letztendlich Ursache für die Entstehung von Thrombosen. Die Selektivität der Bildung von Komplexen aus Hirudin und Thrombin ist in der bivalenten Wechselwirkung des Inhibitors – sowohl mit dem aktiven Zentrum des Enzyms als auch mit einer Substraterkennungsstelle außerhalb des aktiven Zentrums, der sogenannten Fibrin(ogen)bindungsstelle (FBS) – begründet. Die Kenntnis dieser Wirkungsweise ermöglichte die Synthese difunktioneller Thrombininhibitoren basierend auf Hirudinpeptiden. Hirudin und Hirudinmimetica erweisen sich in vivo als sehr potente Antikoagulantien zur Behandlung arterieller und venöser Thrombosen.
Characterization of polychlorinated biphenyl degradation in a fermentor by Comamonas testosteroni strain TK102. (1998)

The degradation of polychlorinated biphenyls (PCBs) in a 10-liter fermentor by Comamonas testosteroni strain TK102 was investigated. The efficient degradation of 100mg/l Kaneclor 300 by strain TK102 was achieved in 1/3 diluted Luria-Bertani (LB) medium in the absence of biphenyl.Eighty seven percent of Kaneclor 300 was transformed within 72h. This is the first report onthe biodegradation of PCBs in a fermentor. During 24h of incubation, PCBs at the initial concentration of 100mg/l were most efficiently degraded. At the concentration of 150 and 200mg/l, the efficient degradation of PCBs began after a 18-h lag period.
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor (2015)

GSK2795039 is a novel NOX2 inhibitor that is the first small molecule to demonstrate inhibition of the NOX2 enzyme in vivo.
Lysosome signaling in cell survival and programmed cell death for cellular homeostasis (2022)

Recent developments in lysosome biology have transformed our view of lysosomes from static garbage disposals that can also act as suicide bags to decidedly dynamic multirole adaptive operators of cellular homeostasis. Lysosome-governed signaling pathways, proteins, and transcription factors equilibrate the rate of catabolism and anabolism (autophagy to lysosomal biogenesis and metabolite pool maintenance) by sensing cellular metabolic status. Lysosomes also interact with other organelles by establishing contact sites through which they exchange cellular contents. Lysosomal function is critically assessed by lysosomal positioning and motility for cellular adaptation. In this setting, mechanistic target of rapamycin kinase (MTOR) is the chief architect of lysosomal signaling to control cellular homeostasis. Notably, lysosomes can orchestrate explicit cell death mechanisms, such as autophagic cell death and lysosomal membrane permeabilization-associated regulated necrotic cell death, to maintain cellular homeostasis. These lines of evidence emphasize that the lysosomes serve as a central signaling hub for cellular homeostasis.
Alcoholic fermentation of sorghum without cooking (1986)

Sorghum was used as raw material for alcoholic fermentation without cooking. Two varieties of sorghum grown in Thailand, KU 439 and KU 257, contained 80.0 and 75.8% of total sugar. Optimum amount of sorghum for alcoholic fermentation should be between 30 and 35% (w/v) in the fermentation broth. In these conditions 13.0 and 12.6% (v/v) of alcohol could be obtained in 84 and 91.9% yield based on the theoretical value of the starch content from KU 439 and KU 257, respectively.
An authentication architecture for cloud-based firewalling service (2015)

The use of cloud computing is growing by 2016, this growth will increase to become the bullk of new IT spend. Companies are interested in outsourcing security service to Cloud providers in order to reduce management and deployment costs. This outsourcing addresses many problems related to identification, authentication, secure data transfer, and privacy in Security As A Service (SECAAS)Model. Our article presents a secure, strong and efficient authentication architecture and identity management for cloud based firewalling service using EAP-TLS smart cards technology.
Finding the Abuser in the Victim (2005)

A period of transition in the life of a forensic outpatient group is described. Transference and countertransference issues were stirred up by the change of conductor, and related to the theme of perversion in the group. In order to preserve confidentiality, the identity of group members is disguised. Their contributions to the group have been combined and changed in order not to represent individuals but to convey the essence of the group process.
Magnolia kobus Extract Suppresses Porphyromonas gingivalis LPS-Induced Proinflammatory Cytokine and MMP Expression in HGF-1 Cells and Regulates Osteoclastogenesis in RANKL-Stimulated RAW264.7 Cells (2023)

Clinical prevention is of utmost importance for the management of periodontal diseases. Periodontal disease starts with an inflammatory response in the gingival tissue, and results in alveolar bone destruction and subsequent tooth loss. This study aimed to confirm the anti-periodontitis effects of MKE. To confirm this, we studied its mechanism of action using qPCR and WB in LPS-treated HGF-1 cells and RANKL-induced osteoclasts. We found that MKE suppressed proinflammatory cytokine protein expression by inhibiting the TLR4/NF-κB pathway in LPS-PG-induced HGF-1 cells and blocking ECM degradation by regulating the expression of TIMPs and MMPs. We also confirmed that TRAP activity and multinucleated cell formation were reduced in RANKL-stimulated osteoclasts after exposure to MKE. These results were confirmed by inhibiting TRAF6/MAPK expression, which led to the suppression of <i>NFATc1</i>, <i>CTSK</i>, <i>TRAP</i>, and MMP expression at the gene and protein levels. Our results confirmed that MKE is a promising candidate for the management of periodontal disease based on its anti-inflammatory effects and inhibition of ECM degradation and osteoclastogenesis.
Novel Substituted Adamantane-spiro-5-oxazolidine Derivatives (1987)

The synthesis of a series of subetituted admantane-spim-~oxaeolidin-2-one (1-6) and adamantane-spim-5oxaeolidine (7-10) derivatives, is described.Compounds 2-10 represent novel adamantane-spim-heterncyclic systems.Recently, ' " we have reported the synthesis of spim[3,4,5,6-tetrahydm-i,4-0~zin-2-0ne-6,2'-tri-