gebhart/patrepeval huggingface dataset:
TOTAL HIP ARTHROPLASTY: TREATMENT OF CHRONIC INSTABILITY USING A DOUBLE-MOBILITY CUP (2002)

Purpose: Dislocation of total hip arthoplasties is a sad reality. The incidence of this complication is estimated from 0.6 to 8%. Dislocation can be a single event that never recurs, but half of all dislocations will reoccur again. We analysed outcome after treating chronically unstable total hip arthroplasties using a double-mobility cup. Material and methods: Between 1990 and 2000, we treated 42 cases of recurrent dislocation of total hip arthroplasties. Five were immediate, 33 early, and four late; five dislocations on the average. The prosthesis was implanted via the posterolateral approach for 36 patients. Thirteen patients treated in our unit had already had surgical treatment for chronic instability: 1 trochanteoplasty, 8 bone blocks, 5 restraining cups. A standing AP view of the pelvis was obtained in all patients before surgery to analyse shortening (gluteus medius insufficiency), cup tilt and anteversion, and stem lateralisation. Likewise a CT scan was performed systematically to analyse stem and cup anteversion. No position anomaly was found in 17 patients; at least one anomaly was found in the others. All patients were reoperated via the posterolateral approach. A double-mobility cup was implanted systematically without changing the stem. Results: Among the 42 patients, we had two with recurrent dislocation, one in a neurologic patient and one in a patient with major anomalies in the position of the femoral component that was not changed. The incidence of recurrent dislocation was thus 4.75%. Discussion: The therapeutic method used here can be compared with other solutions (trochanteroplasty, anti-dislocation crescent, antidislocation bone block, bipolar replacement). The double-mobility cup is particularly interesting for high-risk patients: neck fracture, tumour surgery, neurological disease, antecedent non-prosthetic surgery (dearthrodesis prosthesis). We advocate revision surgery after three dislocations. Conclusion: The double-mobility cup appears to be a valid therapeutic option, both for the treatment and prevention of chronic instability of total hip arthroplasty.
Genetic parameters of feed intake, production, body weight, body condition score, and selected type traits of Holstein cows in commercial tie-stall barns (2010)

The objectives of this study were to determine the feasibility of measuring feed intake in commercial tie-stall dairies and infer genetic parameters of feed intake, yield, somatic cell score, milk urea nitrogen, body weight (BW), body condition score (BCS), and linear type traits of Holstein cows. Feed intake, BW, and BCS were measured on 970 cows in 11 Pennsylvania tie-stall herds. Historical test-day data from these cows and 739 herdmates who were contemporaries during earlier lactations were also included. Feed intake was measured by researchers once per month over a 24-h period within 7 d of 6 consecutive Dairy Herd Information test days. Feed samples from each farm were collected monthly on the same day that feed intake was measured and were used to calculate intakes of dry matter, crude protein, and net energy of lactation. Test-day records were analyzed with multiple-trait animal models, and 305-d fat-corrected milk yield, dry matter intake, crude protein intake, net energy of lactation intake, average BW, and average BCS were derived from the test-day models. The 305-d traits were also analyzed with multiple-trait animal models that included a prediction of 40-wk dry matter intake derived from National Research Council equations. Heritability estimates for 305-d intake of dry matter, crude protein, and net energy of lactation ranged from 0.15 to 0.18. Genetic correlations of predicted dry matter intake with 305-d dry matter, crude protein, and net energy of lactation intake were 0.84, 0.90, and 0.94, respectively. Genetic correlations among the 3 intake traits and fat-corrected milk yield, BW, and stature were moderate to high (0.52 to 0.63). Results indicate that feed intake measured in commercial tie-stalls once per month has sufficient accuracy to enable genetic research. High-producing and larger cows were genetically inclined to have higher feed intake. The genetic correlation between observed and predicted intakes was less than unity, indicating potential variation in feed efficiency.
Paráfrase e memória: estratégias persuasivas do discurso publicitário contemporâneo (2011)

O presente artigo investiga as estratégias criativas da publicidade centradas em conceitos da retórica clássica (precisamente, paráfrase e memória), bem como em teorias mais recentes da linguagem (hipertexto). Escrito por pesquisadores da Espanha e do Brasil, que reúnem interesses comuns no estudo desse objeto, o texto traz, em suas análises, anúncios de ambos os países, demonstrando como os publicitários acionam, num primeiro momento, o tesouro cultural de sua comunidade durante o processo criativo, para, em seguida, ampliá-lo com o conteúdo das peças que elaboram a partir de referências já conhecidas do público.
New oxide phase with wide band gap and high electroconductivity, MgIn2O4 (1992)

It was demonstrated that the MgIn2O4 spinel is a very promising material as a transparent electronic conductor. By the measurements of diffuse reflectance spectra, the optical band gap of MgIn2O4 (∼3.4 eV) was found to be wider than that of ITO (indium tin oxide). Electrical conductivity of the sintered sample of MgIn2O4 at room temperature has reached almost 102 S cm−1 with no intentional doping. The conduction was found to be due to electrons introduced from oxygen vacancies.
Complete temporal optical Fourier transformations using dark parabolic pulses (2009)

A study of the dynamics of temporal optical Fourier transforms is presented in the interest of improving transform quality. Experimental verification of how a complete Fourier transform can be obtained in both domains is demonstrated.
Joint power allocation solutions for power consumption minimization in coordinated transmission system (2011)

The growth in energy consumption followed with global warming provides new topics and issues in communication systems known as green radio. Hence, how to reduce power consumption while meeting system throughput requirement is an urgent task. In this paper, we investigate a new cooperative power allocation scheme for a multi-user orthogonal frequency division multiplex (OFDM) system, in which two coordinated transmission points (CTP) jointly allocate their power to multiple orthogonal subchannels. In order to minimize the overall transmit power consumption while meeting the system total throughput requirement and also each CTP's power constraint, we formulate the objective task into a constrained optimization problem and derived a group of closed form power allocation solutions. The solutions turn out to take the form of traditional water-filling (WF) and also have a cooperative feature. Based on the derived solution, a novel power allocation algorithm with joint minimization power consumption (JMPC-PA) is proposed. Numerical results are presented to verify the optimality of the derived scheme. Considering the flexibility of CTP's category, e.g., base station or relay station, it is known that the derived scheme can be valid for any coordinated networks such as next-generation cellular networks or ad-hoc networks.
Evaluation of the Doppler-Broadening of Gamma-Ray Spectra from Neutron Inelastic Scattering on Light Nuclei (2009)

Neutron‐induced gamma‐ray reactions are extensively used in the nondestructive analysis of materials and other areas where the information about the chemical composition of a substance is crucial. The common technique to find the intensity of the gamma ray is to fit gamma‐ray line shape with an analytical function, for example, a Gaussian. However, the Gaussian fitting may fail if the gamma‐ray peak is Doppler‐broadened since this leads to the miscalculation of the area of the peak and, therefore, to misidentification of the material. Due to momentum considerations, Doppler‐broadening occurs primarily with gamma rays from neutron‐induced inelastic scattering reactions with light nuclei. The recoiling nucleus of interest must have excited states whose lifetimes are much smaller than the time of flight in the material. We have examined various light nuclei bombarded by 14 MeV neutrons to predict when the peak shape of a neutron‐induced gamma ray emitted from these nuclei will be Doppler‐broadened. We have found that nearly all the gamma rays from neutron‐induced gamma‐ray reactions on light elements (A<20) are Doppler‐broadened with only a few exceptions. This means that utilization of resolution curves derived from isotopic sources or thermal neutron capture reactions have little value in the analysis.
STOP Proteins (2003)

Microtubules assembled from purified tubulin in vitro are labile, rapidly disassembling when exposed to a variety of depolymerizing conditions such as cold temperature. In contrast, in many cell types, microtubules seem to be unaffected when the cell is exposed to the cold. This resistance of microtubules to the cold has been intriguing because the earliest and by far most studied microtubule-associated proteins such as MAP2 and tau are devoid of microtubule cold stabilizing activity. Over the past several years, it has been shown that resistance of microtubules to the cold is largely due to polymer association with a class of microtubule-associated proteins called STOPs. STOPs are calmodulin-binding and calmodulin-regulated proteins which, in mammals, are encoded by a single gene but exhibit substantial cell specific variability due to mRNA splicing and alternative promoter use. STOP microtubule stabilizing activity has been ascribed to two classes of new bifunctional calmodulin- and microtubule-binding motifs, with distinct microtubule binding properties in vivo. STOPs seem to be restricted to vertebrates and are composed of a conserved domain split by the apparent insertion of variable sequences that are completely unrelated among species. Recently, STOP suppression in mice has been found to induce synaptic defects associated with neuroleptic-sensitive behavioral disorders. Thus, STOPs are important for synaptic plasticity. Additionally, STOP-deficient mice may yield a pertinent model for the study of neuroleptics in illnesses such as schizophrenia, currently thought to result from defects in synapse function.
Probe directed at a segment of Rickettsia rickettsii rRNA amplified with polymerase chain reaction (1989)

In an effort to explore a sensitive taxon-specific detection system for bacteria, we sequenced the 16S rRNA from two strains of Rickettsia rickettsii, five other rickettsiae, and Coxiella burnetti to find a probe site unique to R. rickettsii. We then synthesized a 16-mer that hybridized only to the rRNA of R. rickettsii. Using a primer complementary to a sequence found only in rickettsial rRNA, we then generated a cDNA. We amplified the probe site in a 180-base segment of the cDNA by using the cDNA primer and a second primer also unique to rickettsiae in a polymerase chain reaction. The segments of rRNA from each of the rickettsiae were amplified 10(6)- to 10(7)-fold, and the R. rickettsii probe hybridized only to the amplified segment from R. rickettsii. The rRNAs from Staphylococcus aureus, C. burnetii, and Neisseria meningitidis were not amplified and did not hybridize with the probe. The approach detailed below may prove clinically useful in the direct detection of pathogens that are difficult to cultivate.
Renormalization and the two-parameter theory. 2. Comparison with experiment and other two-parameter theories (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRenormalization and the two-parameter theory. 2. Comparison with experiment and other two-parameter theoriesJack F. Douglas and Karl F. FreedCite this: Macromolecules 1985, 18, 2, 201–211Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://pubs.acs.org/doi/10.1021/ma00144a017https://doi.org/10.1021/ma00144a017research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spherical Shape Complementarity as an Overriding Motif in the Molecular Recognition of Noncharged Organic Guests by p-Sulfonatocalix[4]arene:  Complexation of Bicyclic Azoalkanes (2005)

[reaction: see text] The complexation of p-sulfonatocalix[4]arene (CX4) with 2,3-diazabicyclo[2.2.1]hept-2-ene (1), 2,3-diazabicyclo[2.2.2]oct-2-ene (2), 2,3-diazabicyclo[3.2.2]non-2-ene (3), 1-methyl-4-isopropyl-2,3-diazabicyclo[2.2.2]oct-2-ene (4), and 1-phenyl-2,3-diazabicyclo[2.2.2]oct-2-ene (5) was studied in D2O at pD 7.4 by 1H NMR spectroscopy. The formation of deep inclusion complexes was indicated by large upfield 1H NMR shifts of the guest protons (up to 2.6 ppm), which were also used to assign, in combination with 2D ROESY spectra, a preferential inclusion of the isopropyl group of 4 and a dominant inclusion of the azo bicyclic residue for 5. The bicyclic azoalkanes 1-3 showed exceptionally high binding constants on the order of 1000 M(-1), 1-2 orders of magnitude larger than for previously investigated noncharged organic guest molecules. The strong binding was attributed to the spherical shape complementarity between the guest and the conical cavity offered by CX4. Interestingly, although the derivatives 4 and 5 are more hydrophobic, they showed a 2-3 times weaker binding, which was again attributed to the deviation from spherical shape in these bridgehead-substituted derivatives. The preferential inclusion of the hydrophilic but spherical bicyclic residue of 5 rather than the hydrophobic aromatic phenyl group provides a unique observation in aqueous host-guest chemistry and corroborates the pronounced spherical shape affinity of CX4.
Mechanistic Insights into Bioengineered Antibiofilm Enamel Pellicles (2023)

Dental caries remains the most widespread chronic disease worldwide. Basically, caries originates within biofilms accumulated on dental enamel. Despite the nonrenewable nature of the enamel tissue, targeted preventive strategies are still very limited. We previously introduced customized multifunctional proteinaceous pellicles (coatings) for controlling bacterial attachment and subsequent biofilm succession. Stemmed from our whole proteome/peptidome analysis of the <i>in vivo</i> acquired enamel pellicle, we designed these pellicles using hybrid mixtures of the most abundant and complementary-acting antimicrobial and antifouling proteins/peptides for synergetic suppression of early biofilms. In conjugating these domains synthetically, their bioinhibitory efficacy was remarkably boosted. Herein, we sought to explore the key structure-function relationship of these potent <i>de novo</i> hybridized conjugates in comparison with their individual domains, solely or in physical mixtures. Specifically, we interrelated the following facets: physicochemical and 3-dimensional folding characteristics via molecular dynamics simulations, adopted secondary structure by circular dichroism, immobilization capacity on enamel through high-spatial resolution multiphoton microscopy, and biofilm suppression potency. Our data showed consistent associations among the increased preference for protein folding structures, α-helix content, and enamel-immobilization capacity; all were inversely correlated with the attached bioburden. The expressed phenotypes could be explained by the adopted strongly amphipathic helical conformation upon conjugation, mediated by the highly anionic and acidic N-terminal pentapeptide shared region/motif for enhanced immobilization on enamel. In conclusion, conjugating bioactive proteins/peptides is a novel translational approach to engineer robust antibiofilm pellicles for caries prevention. The adopted α-helical conformation is key to enhance the antibiofilm efficacy and immobilization capacity on enamel that are promoted by certain physicochemical properties of the constituent domains. These data are valuable for bioengineering versatile therapeutics to prevent/arrest dental caries, a condition that otherwise requires invasive treatments with substantial health care expenditures.
Localization of QTLs for yield and fiber quality traits of tetraploid cotton cultivar. (2003)

Using SSR and RAPD as molecular markers, and the 69 F2 families from a cross between Handan208 (Gossypium hirsutum) and Pima90 (Gossypium barbadense) as a mapping population, a linkage map comprising 126 markers was constructed. With an average spacing 13.7 cM between markers, the linkage map spanned 1,717.0 cM, which covers approximately 34.34% of the total recombinational length of cotton genome. Based on the linkage map and the F2:3 phenotypic data, overall genome QTL screening was conducted by composite interval mapping method, then 29 QTLs related to cotton yield traits and fiber quality traits were found. There are 16 loci related to yield traits and 13 loci related to fiber quality. Particularly, two QTLs relevant to fiber strength were detected, which could explain phenotypic variance of 34.15% and 13.86%, respectively.
"Transcending Without Transcendence": Utopianism and an Ethos of Hope (2006)

Human geography has recently witnessed an emergent interest in the intertwined problematics of how to be utopian and how to remain hopeful or optimistic. This paper aims to introduce a type of immanent utopianism that follows from a dynamic, open, conception of utopia. It revolves around thinking through how an ethos of hope functions in relation to the multiple problems and tasks of utopia/utopianism. The paper describes how Ernst Bloch re-defined the utopian as a type of process and then outlines a style of immanent utopianism based on an explicit ethos of hope. The result is a sensitivity to matter as utopological, as containing an immanent reference to a not-yet beyond, that obliges us to practice a utopianism that intervenes in the emergence, and change, of something better in a world that takes place “in hazard”. In conclusion the paper argues for a utopic geography based on being, and becoming, hopeful that is itself a response to an ethical imperative to give and find hope in the context of the tragedy and injustice of suffering.
Genomic landscape of variant urinary tumor histologies. (2021)

467 Background: The genetics of urothelial carcinoma (UC), the most common histology of urinary tract (UT) tumors, is well characterized; much less is known about the genomic features of rare histologic variants of UT tumors. We aim to compare the genomic alterations (GA) of UT tumors with adenocarcinoma (AD), small cell (SC), squamous cell (SQ), or plasmacytoid (PC) histologies, to UC tumors. Methods: We identified patients with pure variant (AD, SC, SQ, PC) or UC histology with genetic characterization through the GENIE registry. Patient tumor genomic data were captured by Memorial Sloan Kettering Cancer Center (MSK)-IMPACT and Dana-Farber Cancer Institute (DFCI)-Oncopanel NGS initiatives. Tumors with mixed histology were excluded. We limited our analysis to genes tested &gt;1000 times (N=211). Mutation frequencies and copy number variants (CNVs), collectively called GAs, were determined for AD, SC, SQ, PC, and UC, and were compared using the Fisher’s Exact test and Kruskall Wallis test. Nominal p values were obtained, and FDR correction was employed (q &lt; 0.1). Results: We identified 1199 patients with available genomic data who met the inclusion criteria. Histologic distribution was: 32 AD, 13 SC, 15 SQ, 11 PC, and 1128 UC tumors. The median age was 68 years and 77% of patients were male. Statistically significant differences in genetic alterations by subtype are shown in the table below. ARID1A and KDM6A GAs were higher in UC; PC and SC; CDH1 GAs higher in PC; RB1 and TP53 GAs higher in SC; SMAD4 GAs higher in AD; and NFE2L2 GAs higher in SQ. Conclusions: Variant UT histologies exhibit a distinct pattern of alterations compared to UC, consistent with their divergent clinical behavior. This suggests different biological origins for these variant histologies and possibly different therapeutic vulnerabilities. Exploring the GAs of these UT tumors in larger datasets is warranted. [Table: see text]
Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53 (2019)

B-cell prolymphocytic leukemia (B-PLL) is a rare hematological disorder whose underlying oncogenic mechanisms are poorly understood. Our cytogenetic and molecular assessments of 34 patients with B-PLL revealed several disease-specific features and potential therapeutic targets. The karyotype was complex (≥3 abnormalities) in 73% of the patients and highly complex (≥5 abnormalities) in 45%. The most frequent chromosomal aberrations were translocations involving MYC [t(MYC)] (62%), deletion (del)17p (38%), trisomy (tri)18 (30%), del13q (29%), tri3 (24%), tri12 (24%), and del8p (23%). Twenty-six (76%) of the 34 patients exhibited an MYC aberration, resulting from mutually exclusive translocations or gains. Whole-exome sequencing revealed frequent mutations in TP53, MYD88, BCOR, MYC, SF3B1, SETD2, CHD2, CXCR4, and BCLAF1. The majority of B-PLL used the IGHV3 or IGHV4 subgroups (89%) and displayed significantly mutated IGHV genes (79%). We identified 3 distinct cytogenetic risk groups: low risk (no MYC aberration), intermediate risk (MYC aberration but no del17p), and high risk (MYC aberration and del17p) (P = .0006). In vitro drug response profiling revealed that the combination of a B-cell receptor or BCL2 inhibitor with OTX015 (a bromodomain and extra-terminal motif inhibitor targeting MYC) was associated with significantly lower viability of B-PLL cells harboring a t(MYC). We concluded that cytogenetic analysis is a useful diagnostic and prognostic tool in B-PLL. Targeting MYC may be a useful treatment option in this disease.
Combined speed and yaw control of underactuated unmanned surface vehicles (2010)

This paper studies the speed and yaw control problem for an underactuated unmanned surface vehicle (USV) with only two propellers. Firstly, it transforms the dynamical system of speed and yaw into a cascade nonlinear system, and the resulting cascade system can be reduced to the stabilization control problem of a surge speed and yaw subsystem. Secondly, the surge speed and yaw controller are proposed respectively via Lyapunov's direct method and backstepping approach. Then, we demonstrate that the original system state is globally asymptotically stabilized to the desired configuration with the proposed feedback control law. Furthermore, the effectiveness of the proposed method is illustrated and validated by simulation results on a model ship.
Herpesvirus‐Like DNA Sequences in Kaposi's Sarcoma Lesions from Two Women with AIDS (1997)

chloroform extraction and ethanol precipitation of nucleid acids.