gebhart/patrepeval huggingface dataset:
Pathological gambling in Parkinson disease is reduced by amantadine (2010)

To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson disease (PD), 17 PD patients with PG were randomly selected for a double-blind crossover study with amantadine 200mg/day versus placebo and an open follow-up. Assessments included PG-specific scales (Yale-Brown Obsessive-Compulsive Scale for PG, Gambling-Symptom Assessment Scale, South Oaks Gambling Screen) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditure reduction. Amantadine might be useful to treat PG. The effect of amantadine, acting as an antiglutamatergic agent, also opens new insights into the pathogenesis of PG.
Supplementary Figures 1-3 from Selective Role of an NH<sub>2</sub>-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion–Independent Prostate Cancer Cells (2023)

Supplementary Figures 1-3 from Selective Role of an NH&lt;sub&gt;2&lt;/sub&gt;-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion–Independent Prostate Cancer Cells
Estudio preliminar de la obtención de compuestos híbridos de quitosano y polifenoles derivados de lignina a partir de subproductos agropecuarios y pesquería de camarón (2017)

En este estudio se prepararon y caracterizaron microcápsulas híbridas del conjugado de polifenoles derivados de la lignina proveniente de la cáscara de piña, y el quitosano obtenido a partir de la quitina de la cáscara del camarón; ambos materiales fueron obtenidos como residuos de la industria agropecuaria y pesquería de camarón de Costa Rica. Con el objetivo de preparar compuestos fenólicos derivados de la lignina, y utilizarlos en la síntesis de las microcápsulas, se realizó la hidrólisis enzimática de la misma en un reactor a presión atmosférica a un pH de 6.8, en buffer de citrato 1 M, durante 6 h a 37ºC. Las enzimas utilizadas fueron extraídas de los cultivos de hongos de Gloeophyllum trabeum (Pers.) Murrill y Phanerochae chrysosporiumin Burdsall. Para la obtención del quitosano desacetilación alcalina a partir de exoesqueletos del camarón Heterocarpus vicarius Fazon. Para la preparación de las microcápsulas se empleó una disolución de quitosano en ácido acético, el cual fue mezclado con una disolución acuosa del producto obtenido de la hidrólisis de la lignina y luego añadido a una disolución de vaselina para microemulsionar. Posteriormente, se agregó el glutaraldehído como agente entrecruzante. Se obtuvieron microcápsulas con tamaños entre 5 y 10 µm. Estas microcápsulas son un material promisorio ya que, mediante la formación del complejo, se puede aumentar la solubilidad del quitosano y estabilizar los polifenoles, manteniendo así sus propiedades antioxidantes. Los resultados preliminares obtenidos en esta investigación, muestran el potencial de este material para el encapsulamiento de fármacos y pesticidas.
Doping-dependent studies of the Anderson-Mott localization in polyaniline at the metal-insulator boundary (2002)

Temperature-dependent dc conductivity measurements and infrared reflectivity measurements (20--9000 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$) were performed on a series of polyaniline samples with two different dopant acids at various doping levels. The typical fingerprints of a disordered metal such as a positive temperature coefficient of resistivity at high temperatures, a very high reflectivity in the far infrared, and a plasma resonance have been observed. The results were analyzed in the framework of the Anderson-Mott localization model and considerable consistency between transport studies and optical measurements was obtained. Various parameters enabling a comparative classification of the materials are also reported.
Pre-treatment of polychlorinated biphenyl analysis in mineral oils or oily waste muds. (1985)

石油類及び石油を含む油状廃棄物に混入したポリ塩化ビフェニル(PCB)の分析の前処理法を検討した.変圧器油,廃油その他鉱油中のPCB分析の前処理法としては,シリカゲルカラム,フロリジルカラムによる分別溶出,アセトニトリル-ヘキサンによる分配抽出などの組み合わせが検討されてきたが,洋上焼却又は海洋投入処分の基準とされる0.15μg/gの濃度範囲では,十分に信頼できる前処理法が確立されていなかった.すなわち,燃料用B重油にPCB試料を含ませて,環境庁告示で取り上げられた手法で前処理を行い,計測すると,5μg/g程度の濃度付近から混在物の影響とみられるガスクロマトグラフの乱れが目立ち,測定値の演算が著しく困難になる.そのために,従来から知られてきた石油類成分の分画法も援用して,石油類諸成分の排除を図った.各種の前処理法を組み合わせることによって得た測定結果は,0.1μg/gの鉱油試料に対して,87%の回収率で,PCBの標準混合試料と極めて類似したクロマトグラムを与えた.
Development of Abbreviated Nine-Item Forms of the Raven’s Standard Progressive Matrices Test (2012)

The Raven's standard progressive matrices (RSPM) is a 60-item test for measuring abstract reasoning, considered a nonverbal estimate of fluid intelligence, and often included in clinical assessment batteries and research on patients with cognitive deficits. The goal was to develop and apply a predictive model approach to reduce the number of items necessary to yield a score equivalent to that derived from the full scale. The approach is based on a Poisson predictive model. A parsimonious subset of items that accurately predicts the total score was sought, as was a second nonoverlapping alternate form for repeated administrations. A split sample was used for model fitting and validation, with cross-validation to verify results. Using nine RSPM items as predictors, correlations of .9836 and .9782 were achieved for the reduced forms and .9063 and .8978 for the validation data. Thus, a 9-item subset of RSPM predicts the total score for the 60-item scale with good accuracy. A comparison of psychometric properties between 9-item forms, a published 30-item form, and the 60-item set is presented. The two 9-item forms provide a 75% administration time savings compared with the 30-item form, while achieving similar item- and test-level characteristics and equal correlations to 60-item based scores.
Modification of mechanical environment to control vascular organization within developing chicken embryo (2019)

INTRODUCTION: Vascular tree formation and their network organization has previously been shown to be sensitive to the mechanical environment in vitro, yet the specific relationship between the mechanical factors such as geometry, shape, pressure, flow characteristics and vascular organization in vivo is not well understood. The present study aimed to investigate the effect of yolk shape on vascular network organization, within developing chicken embryos cultured in containers with different geometries, resulting in a different mechanical environment of the egg yolk. Using both laser speckle contrast (LSCI) and laser doppler perfusion imaging (LDPI) techniques, the spatiotemporal changes of heart rate and flow velocity in the vascular networks within developing chickenembryos were determined. METHODS: PDMS based artificial egg shell systems: 3D geometric (cube, cylinder and triangular prism shaped) containers based on oxygen permeable thin polydimethylsiloxane (PDMS) membranes were assembled using soft lithographic templates. 3D printed poly(lactic acid) frames were used as mechanical support. Fertilized white leghorn chicken eggs were incubated with 38°C and 65%humidity under regular rotation. After 3-days of incubation, chicken embryos were transferred to the artificial geometric culture systems as shown in the figure.RESULTS &amp; DISCUSSION: Results showed that the heart beat rate (figure -right) and vascular network density were influenced by changing the local mechanical environment of egg yolk. Further, LSCI revealed changes in the perfusion rates within the chick vasculature. Changes in vascular organization with respect to differences in the local microenvironment of the yolk were observed. CONCLUSIONS: With the ultimate goal to understand in vivo vascular organization, fluid flow and growth factor gradient patterns adjacent to the developing chicken blood vessels will next be introduced in the PDMS systems. This 3D integrated platform offers the possibility to evaluate the effect of multiple signals towards vascular organization in a single system.Figure1: (left) chicken embryos exposed to different mechanical environments and (right) variations in perfusion rates of chick vasculature subjected to different mechanical environments.
Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis (2009)

Dasatinib inhibits growth of C4-2B cells in bone with improved efficacy when combined with docetaxel. Additionally, dasatinib inhibits osteolysis associated with CaP. These data support further study of dasatinib in clinical trials for men with CaP bone metastases.
Stereospecific Suzuki Coupling with Inversion of Stereoconfiguration (2010)

This article reports on the Suzuki-Miyaura coupling of enantioenriched α-(acylamino)benzylboronic acid that surprisingly proceeds with inversion of stereoconfiguration.
Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity (2022)

The long-term prevention of biofilm formation on the surface of indwelling medical devices remains a challenge. Silver has been reutilized in recent years for combating biofilm formation due to its indisputable bactericidal potency; however, the toxicity, low stability, and short-term activity of the current silver coatings have limited their use. Here, we report the development of silver-based film-forming antibacterial engineered (SAFE) assemblies for the generation of durable lubricous antibiofilm surface long-term activity without silver toxicity that was applicable to diverse materials via a highly scalable dip/spray/solution-skinning process. The SAFE coating was obtained through a large-scale screening, resulting in effective incorporation of silver nanoparticles (∼10 nm) into a stable nonsticky coating with high surface hierarchy and coverage, which guaranteed sustained silver release. The lead coating showed zero bacterial adhesion over a 1 month experiment in the presence of a high load of diverse bacteria, including difficult-to-kill and stone-forming strains. The SAFE coating showed high biocompatibility and excellent antibiofilm activity <i>in vivo</i>.
Vertical ZnO nanorod/Si contact light-emitting diode (2011)

Blue-white light emission was obtained from glass/indium tin oxide (ITO)/n-ZnO nanorod array (NRA)/p+-Si vertical contact light emitting diodes (VCLEDs). The nanoscale p-n heterojunction VCLEDs were formed by direct engagement n−-tips of n-ZnO NRA grown vertically on an ITO/glass substrate with p+-Si wafer. Proposed configuration of the VCLED allows creating a high density (∼109 cm−2) of self-assembled ZnO/Si nanodiodes with point junctions of high quality due to structural perfection of the Si wafer and the tips of ZnO nanorods as well as providing a high injection current and light emission from the NRA VCLED required for solid state lighting.
Exposure–Response Relationship Between Aircraft Noise and Sleep Quality: A Community-based Cross-sectional Study (2014)

The relationship between aircraft noise and health should be further evaluated through a large-scale follow-up study.
Transurethral bladder catheterization of male rhesus macaques: a refinement of approach (2011)

The urinary bladder of male rhesus can be reliably and reproducibly catheterized with minimal complication using this approach. Successful catheterization was facilitated by thorough urethral lubrication and using suitable catheters. In addition, this approach may be performed without sedation on thoroughly conditioned animals.
Peanut Lectin: A Mitogen for Normal Human Colonic Epithelium and Human HT29 Colorectal Cancer Cells (1992)

It is possible that dietary lectins such as PNA, which bind to the TF antigen, promote cell proliferation and thus cancerous growth, while galactose-containing vegetable fiber would inhibit this effect by competing for binding by these lectins.
Imidazolium-Based Ionic Liquids Affect Morphology and Rigidity of Living Cells: an Atomic Force Microscopy Study (2018)

The study of the toxicity, biocompatibility, and environmental sustainability of room-temperature Ionic Liquids (ILs) is still in its infancy. Understanding the impact of ILs on living organisms, especially from the aquatic ecosystem, is urgent, since on one side large amounts of these substances are widely employed as solvents in industrial chemical processes, and on the other side evidences of toxic effects of ILs on microorganisms and single cells have been observed. To date, the toxicity of ILs have been investigated by means of macroscopic assays aimed at characterizing the effective concentrations (like the EC50) that cause the dead of a significant fraction of the population of microorganisms and cells. These studies allowed to identify the cell membrane as the first target of the IL interaction, whose effectiveness was correlated to the lipophilicity of the cation, i.e. to the length of the lateral alkyl chain. Our study aimed at characterizing the molecular mechanisms of the toxicity of ILs. To this purpose, we carried out a combined topographic and mechanical analysis by Atomic Force Microscopy of living breast metastatic cancer cells (MDA-MB-231) upon interaction with imidazolium-based ILs. We showed that ILs are able to induce modifications of the overall rigidity (effective Young modulus) and morphology of the cells. Our results demonstrate that ILs act on the physical properties of the cell membrane, and possibly induce cytoskeletal reorganization, already at concentrations below the EC50. These potentially toxic effects are stronger at higher IL concentrations, as well as with longer lateral chains in the cation.
Phase II data for entinostat, a class 1 selective histone deacetylase inhibitor, in patients whose breast cancer is progressing on aromatase inhibitor therapy. (2010)

1052 Background: Aromatase inhibitors (AI) block estrogen synthesis and are effective for the treatment of estrogen receptor (ER) positive breast cancer in postmenopausal women. Despite initial benefit, resistance to AIs and disease progression occur, at which point cytotoxic chemotherapy is often the remaining treatment option. Entinostat, an oral class 1 isoform-selective HDACi, has been shown in preclinical studies to restore sensitivity to acquired AI resistance. The goal of this study was to determine whether the addition of entinostat to AI therapy in patients currently progressing on AI therapy could restore AI sensitivity and prolong the clinical benefit. Methods: Postmenopausal women with ER+ breast cancer progressing on an AI after 3 months were enrolled. Additional entry criteria included measurable disease by RECIST and ≤1 chemotherapy for metastatic disease. Patients with rapidly-progressive breast cancer were excluded. Patients continued with the AI on which they progressed plus entinostat 5 mg wkly in 28-day cycles. Primary objective was CBR (CR, PR or SD >6 months) during the first 6 cycles; secondary objectives included ORR and PFS. Biomarkers and pharmacology were also measured. Results: Twenty-seven (27) patients were enrolled with median age of 69 years. Nineteen patients (70%) had visceral involvement; none had bone-only disease. Eighteen (67%) had adjuvant hormone therapy; 14 (52%) had adjuvant chemotherapy. Six (22%) had received chemotherapy in the metastatic setting. Eleven (41%) received study treatment >4 months, 3 (11%) >6 months. One had confirmed PR, and one patient had SD > 6 months. The most common toxicities were nausea, diarrhea, and fatigue, primarily low grade. Grade ≥3 toxicities were fatigue, dyspnea, diarrhea, and lethargy. Biomarker analysis revealed a trend of increased protein lysine acetylation in CD8, CD14, and CD19/20 cells; increased apoptosis in PMCs was also observed. Conclusions: Entinostat in combination with AIs in patients with progressive breast cancer demonstrated clinical benefit as evidenced by PR and SD > 6 months. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Syndax Syndax Syndax
THE ROLLOVER PROPENSITY OF FIFTEEN-PASSENGER VANS (2001)

A question has been raised as to whether fifteen-passenger vans, especially loaded fifteen-passenger vans, are unusually susceptible to rollover. Fifteen-passenger vans differ from most light truck vehicles in that they have a large payload capacity and the occupants sit fairly high up in the vehicle. Therefore, when loaded the vehicle may have a much worse rollover propensity than when unloaded. To examine this issue, a brief study was performed in three parts: a review of crash data to look at the record of fifteen-passenger vans; measurement of the Static Stability Factors (SSF) of a fifteen-passenger van, a seven-passenger van, and a minivan; and a simulation analysis of the handling characteristics of an unloaded and loaded fifteen-passenger van. Results of this study are presented in this Research Note. It was concluded that fifteen-passenger vans might be more likely to roll over when fully loaded with occupants than when lightly loaded. Analysis considering the number of occupants in the vehicle showed that fifteen-passenger vans with ten or more occupants had three times the rollover ratio than those with fewer than ten occupants.
EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans (1998)

During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration.
Time Efficient Service Discovery in Mobile P2P Architectures Using Bluetooth (2008)

Key challenges in mobile ad-hoc networks are computational resource constraints, power limitations and time delays in information exchange. Therefore it is necessary to develop intelligent, efficient indexing strategies for knowledge addressing and exchange in dynamic mobile P2P architectures. The short range radio technology Bluetooth suffers from long service discovery delays and high power consumption due to required connection establishment based on its service-discovery-protocol (SDP). To overcome this situation we propose a new approach. By leveraging the capability of the bluetooth inquiry procedure, we significantly reduce the service discovery time and hence lower the power consumption. Based on a performance evaluation and a comparison with the legacy SDP, we present the benefits of our new approach.
A Seismic Sensor Based on IPMC Combined With Ferrofluids (2013)

In this paper, a seismic sensor based on the combination of ionic polymer metal composite (IPMC) and ferrofluids is presented. The device consists of a vial, filled with ferrofluid, housing an IPMC cantilever beam sensor. Considering that the behavior (e.g., frequency response) of a beam immersed in a fluid changes with the fluid density, in this paper, a novel methodology is proposed to implement a mechanism allowing for the active tuning of the sensor specifications (such as operating range, frequency behavior, and responsivity). To such aim, the addressed methodology exploits external magnetic fields to modify the density of the ferrofluid in which the IPMC sensor is immersed. A description of the sensing methodology and the realization of the sensor prototype are given along with experimental results confirming the expected behavior of the device. Moreover, a model is presented which can be used to predict the IPMC behavior as a function of the fluid properties.
TETRANDRINE INDUCED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT) 3 CAUSES THE REDUCTION OF CELL SURVIVAL, PROLIFERATION, AND ANGIOGENESIS IN TNBC (2014)

Natural agents may be promising to combat aggressive behavior of the triple-negative breast cancer (TNBC). STAT3 is a protein that is highly expressed in breast cancer tissues compared to non-malignant breast tissues. Our objective for the present study is to analyze the anti-tumorogenic effects of a Chinese herbal drug, tetrandrine, in TNBC progression through inhibition of STAT3 phosphorylation.
Amorphous Gallium Oxide‐Based Gate‐Tunable High‐Performance Thin Film Phototransistor for Solar‐Blind Imaging (2019)

Abstract Ga 2 O 3 ‐based solar‐blind photodetectors (PDs) are now attracting more and more attention for their potential application in optical imaging, spatial communication, etc. However, the performance of ever‐reported Ga 2 O 3 ‐based PDs is still not good enough, strongly affected by either the Ga 2 O 3 crystalline quality or the device structure, which severely limits their capability to detect extremely weak signals and achieve future applications. In this work, solar‐blind field‐effect phototransistor based on radio‐frequency‐magnetron sputtered amorphous gallium oxide thin film with ultrahigh photodetection performance are demonstrated. The key feature of the device is gate‐tunable photodetection enabling ultrahigh responsivity of 4.1 × 10 3 A W −1 , external quantum efficiency of 2 × 10 6 %, and detectivity of 2.5 × 10 13 Jones under a 70 µW cm −2 weak signal of 254 nm light due to a high internal gain and field effect control of the phototransistor. Furthermore, high‐resolution imaging is achieved for the imaging target by integrating the as‐fabricated photodetectors into the imaging system, which is the first report on solar‐blind imaging of amorphous gallium oxide photodetectors. Such field‐effect phototransistors with ultrahigh performance and excellent imaging capability address a significant step toward the feasibility and practicability of gallium oxide photodetectors in solar‐blind imaging system.
[RISK OF TUBERCULOSIS INFECTION AND DISEASE AMONG JAPANESE FEMALE NURSES AND MALE DOCTORS IN RECENT YEARS]. (2017)

[Objectives and Materials] Based on the tuber- culosis (TB) surveillance database, the incidence rates of TB infection and active disease among healthcare workers were observed for female nurses and male doctors in 2010 in comparison with those of the general population. [Results] The relative risk (RR) of active TB among female nurses aged 20-69 years was 4.86 (95% confidence interval: 4.31-5.45) for 2010, which has increased from 2.30 observed in 1987-1997. The RR was highest for nurses aged 20-29 years at 8.84 and declined with age until 3.60 for those aged 50-59 years that was still significantly higher than 1. For male doctors the RR was significantly higher than 1 only for those aged 39 years or younger. The rates of those who were -indicated for treatment of latent TB infection (LTBI) were clearly higher among healthcare workers; for female nurses the RR was 32.7 (95% CI: 30.5-35.0), ranging from the highest level of 62.8 among those aged 20-29 years down to 11.6 for those aged 60-69 years. For male doctors also, the RR was high at 9.7 (7.9- 11.7) for 20-69 years, ranging from 14.5 for those aged 20- 29 years down to 5.3 for those aged 60-69 years. [Discussion] TB cases of nurses and doctors were more likely to be detected by the active case finding measures such as periodic screening and contact investigations than cases in the general population, which indicates the current effort of addressing the occupational exposure in the healthcare set- tings. The high level of risk of TB disease as Iwell as LTBI among healthcare professions and its possibly increasing trend as. seen in female nurses warrants further strengthening of monitoring of the problem and overall countermeasures in their workplaces.