gebhart/patrepeval huggingface dataset:
Determinants of the Change in Arterial Stiffness in Peritoneal Dialysis Patients (2017)

Arterial stiffness is an important risk factor for cardiovascular disease (CVD) in patients with end-stage renal failure. However, little is known about the factors that contribute to arterial rigidity in peritoneal dialysis (PD) patients. The aim of this study was to define the pattern and determinants of the longitudinal change in arterial stiffness after PD initiation.Arterial stiffening was estimated for 46 PD patients by using brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (cIMT). The cross-sectional relationship between the arterial markers and their clinical determinants was studied. The longitudinal effects of blood pressure (BP), body fluid status, and glucose were studied over the two years after initiating PD.Multivariate analysis showed that higher baPWV was associated positively with urinary protein excretion (P < 0.001), systolic BP (P = 0.001), and hemoglobin A1c (P = 0.003). In contrast, increased cIMT correlated with smoking (P = 0.004) and hypoalbuminemia (P = 0.04), suggesting that endothelial dysfunction is implicated in the atherogenic process. Neither cIMT nor baPWV correlated significantly with other PD-related covariates of volume overload, peritoneal solute transport, kidney function, and C-reactive protein. Longitudinal observation demonstrated that BP had a greater influence on baPWV changes than hyperglycemia or fluid status.Our study indicates that 1) baPWV represent an arterial marker that integrates multifactorial interaction between modifiable variables including BP and plasma glucose; and 2) intervention aimed at controlling BP as well as nutritional conditions (glucose and albumin) may reduce CVD risk in PD patients.
In vitro toxicity of taxol based anticancer drug combinations on human hemopoietic progenitors. (1999)

The sequence dependency of the interaction of taxol with other anticancer drugs is of clinical importance, and may be due to pharmacokinetic changes and/or to inherent differences in the sensitivity of target normal or cancer cells. This study presents results on the in vitro interaction of taxol with doxorubicin, cisplatin, etoposide and vinorelbine in alternate sequences on human hemopoietic progenitors (CFU-GM). Peripheral blood mononuclear non adherent cells were exposed to IC50 of Taxol for 24 hours and then, for 1 hour to IC50 of each of the other drugs. In a second set of experiments the reverse sequence was applied. The cell suspension was subsequently cultured to assay the growth of CFU-GM. A strong sequence dependency characterizes the combination taxol-vinorelbine, while for the other combinations the order of sequence appears to have little impact on in vitro toxicity on CFU-GM. Comparing results on CFU-GM with that obtained in vitro with the same combination sequences on cancer cell lines some remarkable differences show up. Studies on a normal human myeloid line may therefore have a place in preclinical evaluation of sequence of anticancer drug combinations.
n ‐Propyl Alcohol (2000)

Abstract n ‐Propyl alcohol (1‐propanol) is used primarily as a specialty solvent for printing inks or as a chemical intermediate. The predominant derivatives of n ‐propyl alcohol are the acetate ester and n ‐propylamines. The latter are used in herbicide production. Smaller‐volume uses of n ‐propyl alcohol are as a flavor or fragrance in foods and as feed additive. 1‐Propanol is manufactured in most of the Western world by hydroformylation of ethylene followed by hydrogenation of propanal. The hydroformylation or oxo process is catalyst‐driven. This process is described. In South Africa, 1‐propanol is also produced from coal through Fischer‐Tropsch processes.
Orts- und kontextbezogene Dienste im Youngster-Projekt (Location- and Context-Aware Services in the Youngster Project) (2002)

Um neue, attraktive mobile Dienste für junge Benutzer zu finden, konzentriert sich das Youngster-Projekt auf solche Anwendungen, die den Kontext des Benutzers nutzen und sich so an dessen aktuelle Situation anpassen. In diesem Artikel stellen wir eine Plattform für mobile Dienste vor, die im Rahmen dieses Projektes entwickelt wird. Sie enthält u. a. eine Komponente, die es Diensten erlaubt, auf einheitliche Weise einfach auf Kontextinformationen zuzugreifen. Weiter werden orts- bzw. kontextabhängige Dienste vorgestellt, die auf dieser Plattform aufbauen.
Resource Allocation and Partner Selection for Cooperative Multicarrier Systems (2011)

Subcarrier allocation, power allocation, and partner selection (PS) algorithms are examined for amplify-and-forward (AF) cooperative multicarrier systems. Consider a network that consists of multiple cooperative pairs that employ a two-phase cooperation scheme, where the users first transmit their own messages on each of their subcarriers in phase I and either retransmit their own messages or relay the messages of their partners in phase II. In general, subcarrier allocation and partner selection problems are known to be intractable for systems with large number of users and subcarriers. In this paper, we propose a suboptimal but mathematically tractable approach to address these issues and show its effectiveness compared with existing algorithms. This approach is done by considering the power allocation over a relaxed problem formulation, where each subcarrier is allowed to retransmit or relay for all other subcarriers in phase II over virtually orthogonal channels. The power allocation in this case is a convex optimization problem and, thus, can efficiently be solved. Based on the results of the relaxed power allocation problem, an efficient subcarrier allocation algorithm for the original problem can then be derived by allowing subcarriers to forward the data that are allocated the most power. The results also yield a necessary and sufficient condition on when cooperation is helpful among two users. A partner selection algorithm is then devised based on the criterion given in the condition. With the proposed subcarrier allocation scheme, an iterative procedure is then adopted for resource allocation in the two phases. The complexity of the proposed algorithm is discussed, and its efficacy is demonstrated through numerical simulations.
Radioimmunoassay of Plasma Arginine Vasopressin in Hyponatremic Patients with Congestive Heart Failure (1981)

HYPONATREMIA occurs frequently in patients with congestive heart failure who have moderate fluid intakes (1 to 3 liters per day).1 It is not clear whether persistent release of arginine vasopressin (AVP — the mammalian antidiuretic hormone [ADH]) or intrarenal factors account for this impaired water excretion. When bioassay techniques have been used to assess the role of AVP in the hyponatremia associated with congestive heart failure, the results have been conflicting.2 3 4 5 In this investigation, we used a sensitive radioimmunoassay technique to measure AVP in 37 patients with congestive heart failure and associated hyponatremia. AVP levels were detectable in 30 of . . .
The Influence of CO on Hydrogen Evolution (2017)

Electrochemical impedance spectroscopy (EIS) measurements are performed on an electrochemical sensor exposed to carbon monoxide in a hydrogen environment. Equivalent circuits are fit to data recorded prior to and after CO contamination in order to characterize the changes occurring in the sensor following poisoning of the electrodes, and find that both short time scale (kinetics) and long time scale (diffusion like) phenomena are affected by the presence of CO on the catalyst surface. Further work to more completely describe changes to the sensor is ongoing.
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide (1998)

1. The role of cyclic GMP in the ability of nitric oxide (NO) to decrease intracellular free calcium concentration [Ca2+]i and divalent cation influx was studied in rabbit aortic smooth muscle cells in primary culture. In cells stimulated with angiotensin II (AII, 10(-1) M), NO (10(-10) - 10(-6) M) increased cyclic GMP levels measured by radioimmunoassay and decreased [Ca2+]i and cation influx as indicated by fura-2 fluorimetry. 2. Zaprinast (10(-4) M), increased NO-stimulated levels of cyclic GMP by 3-20 fold. Although the phosphodiesterase inhibitor lowered the level of [Ca2+]i reached after administration of NO, the initial decreases in [Ca2+]i initiated by NO were not significantly different in magnitude or duration from those that occurred in the absence of zaprinast. 3. The guanylyl cyclase inhibitor, H-(1,2,4) oxadiazolo(4,3-a) quinoxallin-1-one (ODQ, 10(-5) M), blocked cyclic GMP accumulation and activation of protein kinase G, as measured by back phosphorylation of the inositol trisphosphate receptor. ODQ and Rp-8-Br-cyclic GMPS, a protein kinase G inhibitor, decreased the effects of NO, 10(-10) - 10(-8) M, but the decrease in [Ca2+]i or cation influx caused by higher concentrations of NO (10(-7) - 10(-6) M) were unaffected. Relaxation of intact rabbit aorta rings to NO (10(-7) - 10(-5) M) also persisted in the presence of ODQ without a significant increase in cyclic GMP. Rp-8-Br-cyclic GMPS blocked the decreases in cation influx caused by a cell permeable cyclic GMP analog, but ODQ and/or the protein kinase G inhibitor had no significant effect on the decrease caused by NO. 4. Although inhibitors of cyclic GMP, protein kinase G and phosphodiesterase can be shown to affect the decrease in [Ca2+]i and cation influx via protein kinase G, these studies indicate that when these mechanisms are blocked, cyclic GMP-independent mechanisms also contribute significantly to the decrease in [Ca2+]i and smooth muscle relaxation to NO.
Low Density Structural RIM II: High Productivity LD-SRIM (1993)

&lt;div class="htmlview paragraph"&gt;Glass mat reinforced structural polyurethane foam or low density structural reaction injection molding (LD-SRIM) has found a niche in the manufacture of high quality, light weight, automotive, interior trim substrates. Current trends in the automotive industry indicate the need for cost reductions without sacrificing quality. A high productivity LD-SRIM system has been developed which meets this need. This cost reduction is achieved by the incorporation of an internal mold release agent and a 25 % decrease in demold time compared to current LD-SRIM technology. These technological advancements give the trim component manufacturer an increase in productivity by eliminating the time and labor required to apply external mold release and a shorter demold time. These advancements also provide for a significant reduction in the volatile organic compounds and cost associated with external mold release agents. Using a production model it has been estimated that a 20% increase in productivity can be achieved with this technology. A comparison of the physical properties of composites made with this system and those of a system currently employed in industry shows that they are very similar.&lt;/div&gt;
Maleimide Photolithography for Single-Molecule Protein−Protein Interaction Analysis in Micropatterns (2010)

Spatial organization of proteins into microscopic structures has important applications in fundamental and applied research. Preserving the function of proteins in such microstructures requires generic methods for site-specific capturing through affinity handles. Here, we present a versatile bottom-up surface micropatterning approach based on surface functionalization with maleimides, which selectively react with organic thiols. Upon UV irradiation through a photomask, the functionality of illuminated maleimide groups was efficiently destroyed. Remaining maleimides in nonilluminated regions were further reacted with different thiol-functionalized groups for site-specific protein immobilization under physiological conditions. Highly selective immobilization of His-tagged proteins into tris(nitrilotriacetic acid) functionalized microstructures with very high contrast was possible even by direct capturing of proteins from crude cell lysates. Moreover, we employed phosphopantetheinyl transfer from surface-immobilized coenzyme A to ybbR-tagged proteins in order to implement site-specific, covalent protein immobilization into microstructures. The functional integrity of the immobilized protein was confirmed by monitoring protein-protein interactions in real time. Moreover, we demonstrate quantitative single-molecule analysis of protein-protein interactions with proteins selectively captured into these high-contrast micropatterns.
HETEROCYCLIC COMPLEXES OF PALLADIUM (II): TEMPLATE SYNTHESIS, SPECTROSCOPIC STUDIES AND BIOCHEMICAL ASPECTS (2001)

Article HETEROCYCLIC COMPLEXES OF PALLADIUM (II): TEMPLATE SYNTHESIS, SPECTROSCOPIC STUDIES AND BIOCHEMICAL ASPECTS was published on August 1, 2001 in the journal Heterocyclic Communications (volume 7, issue 4).
Simplified optimal design of MDOF structures with negative stiffness amplifying dampers based on effective damping (2019)

SUMMARY This paper presents a study on multi‐degree‐of‐freedom (MDOF) structures equipped with a negative stiffness amplifying damper (NSAD). The NSAD not only preserves the negative stiffness feature of negative stiffness devices (NSDs) but also achieves prominent damping magnification effect, substantially reducing a NSD's requirement for high additional damping, which is used to contain the increased displacements resulting from the reduction in overall stiffness of a system. The dynamic equations of MDOF systems with NSADs are described in state–space representation, and the effective damping and frequencies are parametrically studied. Then, a simple optimization method is proposed. A study of the 20‐storey benchmark building shows that NSADs are the most efficient of supplemental devices in reducing interstorey drifts compared with viscous dampers (VDs) and viscoelastic dampers (VEDs) with the same supplemental damping coefficient. For instance, when compared with that of VEDs, the maximal peak interstorey of NSADs can be further reduced by about 30%. In terms of reducing acceleration responses, NSADs perform much better than VDs and VEDs owing to their negative stiffness feature. Partially arranged, NSADs are best implemented at the storeys that have smaller interstorey drift responses. This is because the negative stiffness preserved by NSADs significantly reduces the interstorey drift of storeys without NSADs.
Reflections on the US Guidelines on Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents (2016)

In the first place, the focus on treatment with GH and IGF-I in the guidelines may be interpreted as reinforcement of the traditional idea that every growth disorder has something to do with the GH-IGF-I axis. Instead, Baron et al. [2] convincingly argued that disorders of this axis represent only a small part of the spectrum of growth disorders. In fact, the majority of growth disorders are associated with one of the many other regulatory pathways of the epiphyseal growth plate. With regard to the definitions of the three diagnostic groups, the PES Committee decided to stick to the texts given in the FDA indications, and provide no further explanation of the delimitations and uncertainties of these relatively poorly defined conditions, nor of the diagnostic process to arrive at these diagnoses. While they appropriately refer to the International Classification of Pediatric Endocrine Diagnoses (ICPED) that recently became available (www.icped.org) [3] , even these definitions ofIn this issue of Hormone Research in Paediatrics , Grimberg et al. [1] , on behalf of the Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society, present a very comprehensive and wellstructured paper containing updated and expanded guidelines for growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment in children and adolescents with growth hormone deficiency (GHD), idiopathic short stature (ISS), and primary insulin-like growth factor-I deficiency (PIGFD). It is the result of a very laborintensive endeavor to evaluate a great deal of the relevant literature using a structured analytical method of grading evidence (GRADE), focusing on adult height as the primary efficacy outcome. This is an important and timely paper, as the previous guidelines on the use of GH by a PES Committee were published in 2003, and did not include the use of IGF-I. We believe that the paper may well contribute to an improvement of the quality of treatment with these drugs, and to a more cautious use of GH and IGF-I in short children. In this commentary, we discuss three issues related to the guidelines. First, we shall discuss the definitions and diagnosis of the three conditions that are the subject of the new guidelines, but have not been exhaustively dealt Published online: November 30, 2016 HORMONE RESEARCH IN PAEDIATRICS
OXPHOS and mtDNA alterations in a family with spastic paraparesis (2000)

We suggest the use of a muscle biopsy when examining HSP patients. HSP can represent a disorder of nuclear-mitochondrial intercommunication.
A monoclonal anti-idiotypic antibody against a human monoclonal IgM with specificity for myelin-associated glycoprotein. (1985)

A human monoclonal IgM lambda antibody, directed against MAG, obtained from a patient with polyneuropathy associated with a gammopathy, was used as an immunogen to generate mouse monoclonal anti-idiotype antibodies. One hybridoma antibody, designated A8F2, reacts uniquely with the M-IgM of the patient, shows high affinity binding to the patient's M-IgM, and dose-dependently inhibits binding of the patient's M-IgM to its specific antigen MAG. Thus, A8F2 is a monoclonal anti-idiotype antibody that recognizes a region of the MAG binding site of the patient's IgM. Use of this anti-idiotype antibody in a competition RIA revealed the presence of naturally occurring anti-idiotype in the patient's serum. Because anti-idiotype antibodies may be part of a mechanism for down-regulation of antibody production, the use of A8F2 to induce a specific immunosuppression should be considered.
Exaggerated pulmonary hypertension with monocrotaline in rats susceptible to chronic mountain sickness (1997)

Hilltop (H) strain Sprague-Dawley rats are more susceptible to chronic mountain sickness than are the Madison (M) strain rats. It is unclear what role pulmonary vascular remodeling, polycythemia, and hypoxia-induced vasoconstriction play in mediating the more severe pulmonary hypertension that develops in the H rats during chronic hypoxia. It is also unclear whether the increased sensitivity of the H rats to chronic mountain sickness is specific for a hypoxia effect or, instead, reflects a general propensity toward the development of pulmonary hypertension. Monocrotaline (MCT) causes pulmonary vascular remodeling and pulmonary hypertension. We hypothesized that the difference in the pulmonary vascular response to chronic hypoxia between H and M rats reflects an increased sensitivity of the H rats to any pulmonary hypertensive stimuli. Consequently, we expected the two strains to also differ in their susceptibility to MCT-induced pulmonary hypertension. Pulmonary arterial pressures in conscious H and M rats were measured 3 wk after a single dose of MCT, exposure to a simulated high altitude of 18,000 ft (barometric pressure = 380 mmHg), and administration of a single dose of saline as a placebo. The H rats had significantly higher pulmonary arterial pressures and right ventricular weights after MCT and chronic hypoxia than did the M rats. The H rats also had more pulmonary vascular remodeling, i.e., greater wall thickness as a percentage of vessel diameter, after MCT and chronic hypoxia than did the M rats. The H rats had significantly lower arterial PO2 than did the M rats after MCT, but the degree of hypoxemia was mild [arterial PO2 of 72.5 +/- 0.8 (SE) Torr for H rats vs. 77.4 +/- 0.8 Torr for M rats after MCT]. The H rats had lower arterial PCO2 and larger minute ventilation values than did the M rats after MCT. These ventilatory differences suggest that MCT caused more severe pulmonary vascular damage in the H rats than in the M rats. These data support the hypothesis that the H rats have a general propensity to develop pulmonary hypertension and suggest that differences in pulmonary vascular remodeling account for the increased susceptibility of H rats, compared with M rats, to both MCT and chronic hypoxia-induced pulmonary hypertension.
Mean diameter of nucleolar bodies in cultured human leukemic myeloblasts is mainly related to the S and G2 phase of the cell cycle. (2008)

Mean diameter of nucleolar bodies (nucleoli without the perinucleolar chromatin) per cell was studied in human leukemic myeloblasts represented by K 562 and Kasumi 1 cell lines which originated from chronic and acute myeloid leukaemia. The measurement of mean diameter of nucleolar bodies in specimens stained for RNA was very simple. Such approach eliminated the variability of the perinucleolar chromatin discontinuous shell which might influence the measured nucleolar size as suggested by earlier studies. Ageing of K 562 myeloblasts produced a significant decrease of cells in S+G2 phase of the cell cycle accompanied by a significant reduction of mean diameter of nucleolar bodies (MDNoBs) per cell. In contrast, treatment of Kasumi 1 myeloblasts with histone deacetylase inhibitor - Trichostatin A - produced a large incidence of resistant cells in S+G2 phase which were characterised by a large increase of MDNoBs. Thus, MDNoBs in leukemic myeloblasts might be a helpful tool to estimate the incidence of cells in the S+G2 phase at the single cell level in smear preparations when the number of cells is very small.
Validation of post-operative atrial fibrillation in the Western Denmark Heart Registry. (2015)

not relevant.
Transparent nylon 6 nanofibers-reinforced epoxy matrix composites with superior mechanical and thermal properties (2023)

Electrospun nanofibers have been widely researched for their reinforcing ability in polymer composites because of their ultrafine size, high mechanical strength, and ultrahigh surface area. In this study, a vacuum infiltration technique was employed to fabricate electrospun nylon 6 nanofiber-reinforced epoxy matrix composites. It was found that the reinforcement of the epoxy matrices with nylon 6 nanofibers significantly improved the mechanical and thermal properties of the composites. The ultimate tensile strength of the N6/YD composite decreased compared to that of the reference YD epoxy resin; however, the N6/YDJR and N6/JR epoxy resin composites showed 29% and 500% improvement in the tensile strength, and Young's modulus was enhanced by 20.5%, 49%, and 1700% for the N6/YD, N6/YDJR, and N6/JR composites, respectively. Furthermore, the tensile strength and Young's modulus of the nanocomposites were predicted and validated using the theoretical Halpin–Tsai and Takayangi models, while the results of numerical simulations agreed with the experimental measurements. Finally, a thermogravimetric analysis showed that the thermal stability of the epoxy resin matrices was significantly improved after the incorporation of nylon 6 nanofibers.
Role of a human digestive strain of Bacteroides thetaiotaomicron in the metabolism of food-borne glucosinolates (1998)

sit time in left colon and faecal levels of propionibacteria and bifidobacteria dur- ing ingestion period.