gebhart/patrepeval huggingface dataset:
Ibrutinib for the treatment of chronic lymphocytic leukemia andmantle cell lymphoma (2014)

Ibrutinib is a novel oral tyrosine kinase inhibitor that irreversibly binds and inhibits tyrosine-protein kinase BTK (Bruton tyrosine kinase). BTK has been found to be important in the function of B-cell receptor signaling and therefore in the maintenance and expansion of various B-cell malignancies including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). Targeting BTK with ibrutinib has been found to be an effective strategy in treating these malignancies. Phase I clinical testing in non-Hodgkin's lymphomas and CLL showed that the drug was extremely well tolerated with no major dose-limiting toxicities and a 54% overall response rate. Subsequently, two phase Ib/II studies were performed on patients with CLL, one in relapsed/refractory CLL and one in previously untreated elderly patients with CLL. Both of these studies continued to show good tolerability of the drug and an overall response rate of about 71% with extended duration of response. Another phase II study using ibrutinib in relapsed/refractory MCL was conducted and also showed that it was well tolerated with an overall response rate of 68% and extended duration of response. Due to these results, the U.S. Food and Drug Administration granted accelerated approval for ibrutinib in November 2013 for patients with MCL who had received at least one prior therapy and in February 2014 for patients with CLL who had received at least one prior therapy. This review will discuss the preclinical pharmacology, pharmacokinetics and clinical efficacy to date of ibrutinib in the treatment of CLL and MCL.
Original Article : Study on Differentiation of Mesenchymal Stem Cells byMechanical Stimuli and an Algorithm for Bone Fracture Healing (2011)

Different from primitive tissue engineering, current tissue engineering and biomedical research focuses on tissue regeneration using stem cells. By autotransplantation, Adult stem cells can overcome problems that embry-onic stem cells have, such as immunologic disharmony, and formation of variant carcinomas, making adult stem cell research more prominent. In differentiation of adult stem cells, mechanical stimuli are one of the most important factors in that they enhance differentiation. In case of mesenchymal stem cells, it can be differentiated into fibro-blasts, chondrocytes, and osteoblasts by the magnitude of mechanical stimuli. Additionally, the magnitude and fre-quency of mechanical stimuli is a key factor to determining the proliferation rate of each tissue. Therefore, the purpose of this research is to study tissue differentiation by mechanical stimuli. Tissue differentiation algorithm by magnitude of mechanical stimuli was suggested, and tissue proliferation and apoptosis was modeled mathematically. The cell density of each phenotype was predicted using numerical models of tissue differentiation and proliferation. Cell experimental data were used to determine differentiation and proliferation patterns. A numerical model predict-ing tissue differentiation by the magnitude and frequency of mechanical stimuli was suggested, and bone fracture healing was simulated. The results from the numerical model analysis, using magnitude and frequency as cell pro-liferation controlling factor, showed better description about bone healing process. With simulation of bone healing process with two numerical models, the model with considering proliferation and apoptosis rate gives more accurateresult. Time for bone fracture healing was shorter in model with the proliferation and apoptosis rate, and more fit to validation data.
Influence of Hydrogen Incorporation on the Reliability of Gate Oxide Formed by Using Low-Temperature Plasma Selective Oxidation Applicable to Sub-50-nm W-Polymetal Gate Devices (2008)

This letter reveals the physical and electrical properties of silicon dioxide (Si02) formed by the plasma selective oxidation (plasma selox) using 02 and H2 gas mixture, which is applicable to sub-50-nm tungsten-polymetal gate memory devices without capping nitride film. Metal-oxide-semiconductor capacitors with gate oxide formed by the plasma selox at the process temperature in the range of 400degC-700degC showed much better time-dependent dielectric-breakdown characteristics than those formed by the conventional thermal selox at 850degC. On the other hand, in the case of very low temperature (25degC) plasma selox, the gate oxide degradation such as initial breakdown was found. It turned out to be due to the excessive hydrogen and water incorporation into the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> layer through thermal desorption spectroscopy measurements.
Age-Dependent and Lobe-Specific Spontaneous Hyperplasia in the Brown Norway Rat Prostate1 (1998)

We showed previously that exogenously administered testosterone caused age- and lobe-specific overgrowth of the prostate in Brown Norway rats. A common feature observed in testosterone-treated animals was cell hypertrophy in each of the ventral, dorsal, and lateral lobes of both young (6 mo old) and old (24 mo old) rats. By contrast, hyperplasia was seen only in the dorsal and lateral lobes of old rats treated with testosterone. These observations prompted us to examine whether age- and lobe-specific overgrowth might also occur in untreated rats as a consequence of the endogenous hormonal milieu. To this end, blood and prostates were collected from a large number (25-30 rats per group) of 4- to 6-mo-old (young) and 21- to 24-mo-old (old) Brown Norway rats. Both serum testosterone (-45%) and estradiol (-22%) concentrations decreased significantly with age, but the greater magnitude of the decrement in testosterone relative to estradiol led to a reduction in the serum testosterone:estradiol ratio. Paradoxically, although the prostate is androgen dependent, the wet weight, protein, and DNA contents increased significantly with age in the dorsal and lateral lobes of old rats despite the decrease in testosterone level. Histologic examination revealed that the increased weights and DNA contents of the dorsal and lateral lobes in old rats coincided with an increased number of epithelial cells in the distal and intermediate segments of these lobes, indicative of hyperplasia but independent of change in cell size. Taken together, these results show a spontaneous age-related overgrowth of cells in the dorsal and lateral prostatic lobes of old Brown Norway rats despite diminished serum testosterone concentrations. The aging Brown Norway rat, therefore, may be a useful model for studies of some aspects of the pathogenesis underlying spontaneous age-related prostatic hyperplasia.
Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15 (2003)

Autosomal recessive hereditary motor and sensory neuropathy or Charcot-Marie-Tooth disease (CMT) is a severe childhood-onset neuromuscular disorder. Autosomal recessive CMT is genetically heterogeneous with one locus mapped to chromosome 11p15 (CMT4B2). The histopathological hallmarks of CMT4B2 are focal outfoldings of myelin in nerve biopsies. Homozygosity mapping, in a Turkish inbred family with four children affected by CMT characterized by focally folded myelin, provided linkage to the CMT4B2 locus. We identified a large, novel gene, named SET binding factor 2 (SBF2), that lies within this interval and is expressed in various tissues, including spinal cord and peripheral nerve. SBF2 is a member of the pseudo-phosphatase branch of myotubularins and was an obvious candidate for CMT4B2 by virtue of its striking homology to myotubularin-related protein 2 (MTMR2), causing another form of autosomal recessive CMT with outfoldings of the myelin sheaths. Molecular study of the SBF2 gene in the CMT4B family demonstrated the presence of a homozygous inframe deletion of SBF2 exons 11 and 12 in all four affected individuals. On the protein level, this mutation is predicted to disrupt an N-terminal domain that is conserved in SBF2 and its orthologues across species. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Localization of SBF2 within the candidate interval, cosegregation with the disease, expression in the peripheral nervous system, and resemblance of the histopathological phenotype to that related to mutations in its paralogue MTMR2 indicate that this gene is the CMT4B2 gene.
Sibling Journal to Advanced Photonics: Advanced Photonics Nexus (2022)

<i>Advanced Photonics Nexus</i>, co-published by SPIE and Chinese Laser Press, is a Gold Open Access, international journal that publishes novel results of high significance and broad interest in all areas of optics and photonics.
Verification of Revised Water Vapour Correction to the Index of Refraction of Air (1992)

The Edlén equation has become the standard method of relating the index of refraction of air to the air temperature, pressure and humidity. The recent suggestion for improvements in the humidity dependence by Birch and Downs has been verified at the 0,633 μm He-Ne laser wavelength using the line scale interferometer at the National Institute of Standards and Technology (NIST).
Glossary of Terms Relating to Electronic, Photonic and Magnetic Properties of Polymers (2023)

These recommendations are specifically for polymers and polymer systems showing a significant response to an electromagnetic field or one of its components (electric field or magnetic field), i.e., for electromagnetic-field-responsive polymer materials. The structures, processes, phenomena and quantities relating to this interdisciplinary field of materials science and technology are herein defined. Definitions are unambiguously explained and harmonized for wide acceptance by the chemistry, physics, polymer and materials science communities. A survey of typical electromagnetic-field-responsive polymers is included.
NAT Port Mapping Protocol (NAT-PMP) (2013)

This document describes a protocol for automating the process of creating Network Address Translation (NAT) port mappings. Included in the protocol is a method for retrieving the external IPv4 address of a NAT gateway, thus allowing a client to make its external IPv4 address and port known to peers that may wish to communicate with it. From 2005 onwards, this protocol was implemented in Apple products including Mac OS X, Bonjour for Windows, and AirPort wireless base stations. In 2013, NAT Port Mapping Protocol (NAT-PMP) was superseded by the IETF Standards Track RFC "Port Control Protocol (PCP)", which builds on NAT-PMP and uses a compatible packet format, but adds a number of significant enhancements.
Secure Identification for Gaussian Channels (2020)

New applications in modern communications are demanding robust and ultra-reliable low latency information exchange such as machine-to-machine and human-to-machine communications. For many of these applications, the identification approach of Ahlswede and Dueck is much more efficient than the classical transmission scheme proposed by Shannon. Previous studies concentrate mainly on identification over discrete channels. We focus on Gaussian channels for their known practical relevance. We deal with secure identification over Gaussian channels. In particular, we provide a suitable coding scheme for the Gaussian wiretap channel (GWC) and determine the corresponding secure identification capacity.
Automatic tuning and matching of a small multifrequency saddle coil at 4.7 T (2004)

A new circuit design for automatically tuning and matching a saddle coil for small animal imaging is presented. This design allows working at (1)H, (19)F, and (3)He resonance frequencies in a 4.7 T spectrometer. It is based on a balanced circuit with commercial variable capacity diodes controlled by a computer using digital potentiometers. The change between two different frequencies can be accurately performed in a few seconds. System Q is compared, between 140-210 MHz, to the same coil tuned and matched with high Q variable capacitors. Differences lower than 5% were found with a loaded coil. The proposed design has initially been evaluated in (19)F and (1)H NMR images acquired with a five-tube phantom. An application is also shown for the acquisition of (3)He, (19)F, and (1)H lung images in a control rat.
CD5 antibodies increase intracellular ionized calcium concentration in T cells. (1987)

The binding of a variety of monoclonal antibodies to the CD5 (T, gp67) pan T cell differentiation antigen has been shown to potentiate T cell proliferation. In this paper we show that CD5 monoclonal antibodies cause increased intracellular free calcium concentration ([Ca2+]i) in T cells. An increase in [Ca2+]i occurred within 1 min in indo-1-loaded PBMC after the addition of CD5 monoclonal antibodies and cross-linking with a second step anti-mouse kappa light chain antibody. Cross-linking of CD5 was effective when done directly on the cell surface or by the administration of preformed soluble complexes that contained CD5 antibodies. Calcium mobilization induced by suboptimal concentrations of CD3 antibodies was specifically augmented and sustained by CD5 antibodies, although the enhancement was modest in magnitude. When cell surface phenotype was correlated with calcium mobilization, it was found that the CD5 response was restricted to CD5+/CD3+ cells, and that approximately 90% of CD5+ cells had responded. CD5-induced calcium mobilization was found to differ from CD3 stimulation in that EGTA entirely ablated the CD5 response, whereas the CD3 response was resistant to EGTA, indicating that the CD5-induced increased [Ca2+]i is derived primarily or entirely from extracellular calcium. CD5-stimulated calcium mobilization also differed from CD3 in that the CD5 response was inhibited by pretreatment with phorbol myristate acetate, whereas the CD3 response was not, suggesting that depletion of protein kinase C causes an uncoupling of signal transduction between CD5 and calcium channels. Finally, experiments were done with T cells after antigenic modulation of the CD3 or CD5 molecules. Unexpectedly, both the CD5 and the CD3 responses were ablated on CD3-modulated cells, whereas only the CD5 response was ablated on CD5-modulated cells. In addition, several Cd5+/CD3- T cell leukemia lines also failed to respond to CD5 stimulation, providing further evidence which indicates that the CD5 response depends on the cell surface expression of CD3 or a CD3-associated structure. These findings suggest that one mechanism for CD5-induced augmentation of mitogen-stimulated T cell proliferation involves increased [Ca2+]i which is distinct from but interdependent with that induced by stimulation of the CD3 molecule.
Triethylborane-Induced Hydrodehalogenation of Organic Halides by Tin Hydrides (1989)

Abstract The reduction of organic halides with tributyltin hydride in the presence of a catalytic amount of triethylborane has been studied. (1) Alkyl iodides and alkyl bromides reacted easily with tin hydride at −78°C to give the corresponding hydrocarbons, while alkyl chlorides were sluggish to react and recovered unchanged. (2) The reduction of alkenyl halides such as 1-deuterio-1-iodo-1-dodecene and 1-iodo-1-triethylsilyl-1-dodecene proceeded nonstereospecifically. (3) The reduction of aryl halides with n-Bu3SnH–Et3B system was not so effective as the reduction of alkyl halides and alkenyl halides. Whereas aryl iodides were reduced at room temperature with n-Bu3SnH, aryl bromides hardly reacted with n-Bu3SnH even at 80 °C.
Temperature and species-dependent regulation of browning in retrobulbar fat (2021)

Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular brown fat. In contrast, human retrobulbar fat closely resembles white adipose tissue. Retrobulbar fat is also brown in other rodents, which are typically housed at temperatures below thermoneutrality, but is white in larger animals. We show that retrobulbar fat in mice housed at thermoneutral temperature show reduced expression of the brown fat marker Ucp1, and histological properties intermediate between white and brown fat. We conclude that retrobulbar fat can potentially serve as a site of active thermogenesis, that this capability is both temperature and species-dependent, and that this may facilitate regulation of intraocular temperature.
Nonlinear code design for joint energy and information transfer (2015)

Harvesting energy from radio frequency signals along with transmitting data through them is appealing for different wireless communication scenarios such as RFID systems and implantable devices. In this paper, we propose a technique to design nonlinear codes for use in such systems taking into account both energy transmission and error rate requirements. Specifically, we propose using concatenation of a nonlinear trellis code with an outer low density parity check code. Via examples, we observe that our designed codes operate at SNRs 2.4dB away from information theoretic limits, and they outperform reference schemes of concatenating LDPC codes with nonlinear memoryless mappers and using classical linear block codes in a time switching mode. We note that it is possible to close the gap to the information theoretic limits further by more sophisticated receiver designs and more complex encoders.
Understanding of a product/service system design: a holistic approach to support design for remanufacturing (2014)

A product/service system (PSS) facilitates remanufacturing and thus is the article’s subject. This article presents a first quantitative analysis, through a descriptive study, of the details of a PSS design case. To do so, an example of PSS design was conducted using a real offering in the marketplace, and this design episode was analyzed through protocol analysis developed further by the authors. The results of the analysis include reasonable hypotheses: PSS design begins with needs by and value for a customer, addresses primarily life cycle activities for solutions, and ends back with value. In addition, life cycle activities, which accounted for about 30% of the episode, were found to be given a central role within PSS design. Furthermore, reasoning about problems, which spent more than 30% of the design, seems to be a new and important type of activity in PSS design as compared to physical product design. This article contributes to greater understanding of PSS design process in quantitative terms and thus to developing effective support for PSS design. Knowledge about PSS enables the understanding of remanufacturing with a more holistic perspective and thus creating an opportunity for better optimization of remanufacturers’ activities.
Design and Optimisation of an Antenna Array for WIMAX Base Stations (2005)

To increase the capacity and coverage in broadband data communication according to the IEEE 802.16e WiMAX standard, in intelligent base station antenna with beam- and nullsteering over a full circle is developed and optimised. In this paper a circular antenna array of 8 vertical dipoles with a feeding network is described, which provides m beams simultaneously in m directions for m subscribers with a full coverage of 360/spl deg/ around the basestation. By means of optimisation techniques it is either possible to provide a null without ambiguity in every direction, or to optimize the side lobe attenuation by calculating the amplitudes and phases of every antenna of the array. With this, detection finding or location based services are also possible.
Compatible genericity with run-time types for the Java programming language (1998)

The most serious impediment to writing substantial programs in the Java&trade; programming language is the lack of a gentricity mechanism for abstracting classes and methods with respect to type. During the past two years, several research groups have developed Java extensions that support various forms of genericity, but none has succeeded in accommodating general type parameterization (akin to Java arrays) while retaining compatibility with the existing. Java Virtual Machine. In this paper, we explain how to support general type parameterization---including both non-variant and covariant subtyping---on top of the existing Java Virtual Machine at the cost of a larger code footprint and the forwarding of some method calls involving parameterized classes and methods. Our language extension is forward and backward compatible with the Java 1.2 language and run-time environment: programs in the extended language will run on existing Java 1.2 virtual machines (relying only on the unparameterized Java core libraries) and all existing Java 1.2 programs have the same binary representation and semantics (behavior) in the extended language.
Magnetic Nanoparticles with Surface Nanopockets for Highly Selective Antibody Isolation (2021)

Monoclonal antibodies (mAbs) are key components of revolutionary disease immunotherapies and are also essential for medical diagnostics and imaging. The impact of cost is illustrated by a price >$200,000 per year per patient for mAb-based cancer therapy. Purification represents a major issue in the final cost of these immunotherapy drugs. Protein A (PrA) resins are widely used to purify antibodies, but resin cost, separation efficiency, reuse, and stability are major issues. This paper explores a synthesis strategy for low-cost, reusable, stable PrA-like <i>nanopockets</i> on core-shell silica-coated magnetic nanoparticles (NPs) for IgG antibody isolation. Mouse IgG<sub>2a</sub>, a strong PrA binder, was used as a template protein, first attaching it stem-down onto the NP surface. The stem-down orientation of IgG<sub>2a</sub> on the NP surface before polymerization is critical for designing the films to bind IgGs. Following this, 1-tetraethoxysilane and four organosilane monomers with functional groups capable of mimicking binding interactions of proteins with IgG antibody stems were reacted to form a thin polymer coating on the NPs. After blocking nonspecific binding sites, removal of the mouse IgG<sub>2a</sub> provided nanopockets on the core-shell NPs that showed binding characteristics for antibodies remarkably similar to PrA. Both smooth and rough core-shell NPs were used, with the latter providing much larger binding capacities for IgGs, with an excellent selectivity slightly better than that of commercial PrA magnetic beads. This paper is the first report of IgG-binding NPs that mimic PrA selectivity. These nanopocket NPs can be used for at least 15 regeneration cycles, and cost/use was 57-fold less than a high-quality commercial PrA resin.
How Can Dolphins Recognize Fish According to Their Echoes? A Statistical Analysis of Fish Echoes (2010)

Echo-based object classification is a fundamental task of animals that use a biosonar system. Dolphins and porpoises should be able to rely on echoes to discriminate a predator from a prey or to select a desired prey from an undesired object. Many studies have shown that dolphins and porpoises can discriminate between objects according to their echoes. All of these studies however, used unnatural objects that can be easily characterized in human terminologies (e.g., metallic spheres, disks, cylinders). In this work, we collected real fish echoes from many angles of acquisition using a sonar system that mimics the emission properties of dolphins and porpoises. We then tested two alternative statistical approaches in classifying these echoes. Our results suggest that fish species can be classified according to echoes returning from porpoise- and dolphin-like signals. These results suggest how dolphins and porpoises can classify fish based on their echoes and provide some insight as to which features might enable the classification.