gebhart/patrepeval huggingface dataset:
Effect of Anti-IL-5 Monoclonal Antibody on Allergic Bronchial Eosinophilia and Airway Hyperresponsiveness in Mice. (1994)

The effect of pretreatment with rat anti-murine interleukin-5 (IL-5) antibody on antigen-induced bronchial eosinophilia and bronchial reactivity to acetylcholine in mice were studied. Three inhalations of an antigen by actively sensitized animals resulted in an increase in airway reactivity to acetylcholine. Twenty-four hours after the final inhalation, the number of leukocytes (mononuclear cells and eosinophils) and the amount of IL-5 in BALF increased significantly. Anti-IL-5 monoclonal antibody inhibited the antigen-induced increase of eosinophils with little effect on bronchial hyperreactivity.
Metabolism of (—)-kaurene-3H and (—)-kaurenol-3H during the photoperiodic floral induction in Pharbitis nil1 (1971)

Journal Article Metabolism of (—)-kaurene-3H and (—)-kaurenol-3H during the photoperiodic floral induction in Pharbitis nil Get access Go TAKEBA, Go TAKEBA Laboratory of Applied Botany, Faculty of Agriculture, Kyoto UniversityKyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar ATSUSHI TAKIMOTO ATSUSHI TAKIMOTO Laboratory of Applied Botany, Faculty of Agriculture, Kyoto UniversityKyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar Plant and Cell Physiology, Volume 12, Issue 1, February 1971, Pages 81–88, https://doi.org/10.1093/oxfordjournals.pcp.a074607 Published: 01 February 1971 Article history Received: 24 September 1970 Published: 01 February 1971
Sensitization to Cockroach Allergen: Immune Regulation and Genetic Determinants (2012)

Asthma is a major public health concern. Cockroach allergen exposure and cockroach allergic sensitization could contribute to the higher prevalence of asthma. However, the underlying immune mechanism and the genetic etiology remain unclear. Recent advances have demonstrated that several receptors (PAR-2, TLRs, CLRs) and their pathways mediate antigen uptake from the environment and induce allergies by signaling T cells to activate an inappropriate immune response. Cockroach-derived protease can disturb airway epithelial integrity via PAR-2 and leads to an increased penetration of cockroach allergen, resulting in activation of innate immune cells (e.g., DCs) via binding to either TLRs or CLRs. The activated DCs can direct cells of the adaptive immune system to facilitate promotion of Th2 cell response and subsequently increase risk of sensitization. Mannose receptor (MR), as a CLR, has been shown to mediate Bla g2 (purified cockroach allergen) uptake by DCs and to determine allergen-induced T cell polarization. Additionally, genetic factors may play an important role in conferring the susceptibility to cockroach sensitization. Several genes have been associated with cockroach sensitization and related phenotypes (HLA-D, TSLP, IL-12A, MBL2). In this review, we have focused on studies on the cockroach allergen induced immunologic responses and genetic basis for cockroach sensitization.
The Chromium-Cryolite Chromizing Process (1964)

SummaryThe effect of variation of the particle size of chromium powder on the chromium uptake and specimen weight gain during the chromizing of mild steel with a chromium-cryolite medium has been studied at 1200°C. The available thermodynamic data for the system has been assessed and the experimental results interpreted with respect to the mechanism of the process. Chromium is supplied to the specimen surface by both an exchange mechanism of the type CrFn+Fe⇌FeFn+Cr and by direct cementation. If the chromium powder particle radii are <30μ, the rate of supply of chromium to the specimen surface is sufficiently great for the overall rate of chromizing to be controlled by the rate of iron-chromium interdiffusion. Under these conditions, the exchange reaction predominates. With particles of r > 30μ cementation becomes predominant and the rate of chromizing becomes controlled by the rate of supply of chromium to the surface. Further studies indicate that for iron and low carbon steels the proportion of chromium supplied by the exchange mechanism increases with chromizing time and temperature whereas for high carbon steels the cementation mechanism is of greater significance.
Precise, Compact, and Fast Data Access Counters for Automated Physical Database Design (2021)

Today's database management systems offer numerous tuning knobs that allow an adaptation of the database behavior to specific customer needs
Tissue‐specific expression of profilin (1989)

Expression of profilin and profilin:actin ratios in vertebrates were determined with polyclonal antibodies against profilin and actin. Profilin was detected in a wide variety of bovine tissues and was enriched in smooth muscle of bovine, porcine and avian origin. The protein was purified from pig stomach muscle tissue. Smooth muscle profilin was found to be more effective in inhibiting the polymerization of skeletal muscle actin than thymus profilin purified by the same method.
Adaptive Search Based Non-Local Means Image De-Noising (2009)

Non-Local Means (NLM) is currently a leading approach in the image de-noising field. It uses the weighted average of all pixels in an image to recover the noise-free pixel values. However, if the pixel values used for average do not lie in the same gray levels as the one to be restored, they will make negative contributions to the de-noising performance. In this paper, we present an adaptive search based image de-noising method that combines the Non-Local Means algorithm with a locally adaptive anisotropic estimation technique, which can select the "right" pixels for NLM averaging process. Experiment results show that the proposed algorithm has superior performance than the original one in terms of PSNR^ SSIM, and also in visual quality.
Enzymatic Hydrolysis of Ethanol-insoluble Proteins from Royal Jelly and Identification of ACE Inhibitory Peptides (2006)

エタノールを用いたRJエキス調製時に不溶性沈殿物として派生し，廃棄されているエタノール不溶性画分（エタノール不溶性RJ）の高機能化を目指し，以下の知見を得た．（1）エタノール不溶性RJをorientase ONSを用いて加水分解処理することにより，水溶性ペプチド素材を82％の高収率で得ることが可能となった．（2）0.4wt％の酵素添加量，2時間，50℃の反応によってACEに対して阻害作用を有する素材を調製し得た．（3）8種類のACE阻害ペプチドの同定とSHRに対する血圧低下作用を明らかにし，未利用資源であったエタノール不溶性RJが機能性食品素材として新たに展開可能なことを示した．
Microbiological and Biochemical Aspects of Camembert-Type Cheeses Depend on Atmospheric Composition in the Ripening Chamber (2006)

Camembert-type cheeses were prepared from pasteurized milk seeded with Kluyveromyces lactis, Geotrichum candidum, Penicillium camemberti, and Brevibacterium aurantiacum. Microorganism growth and biochemical dynamics were studied in relation to ripening chamber CO(2) atmospheric composition using 31 descriptors based on kinetic data. The chamber ripening was carried out under 5 different controlled atmospheres: continuously renewed atmosphere, periodically renewed atmosphere, no renewed atmosphere, and 2 for which CO(2) was either 2% or 6%. All microorganism dynamics depended on CO(2) level. Kluyveromyces lactis was not sensitive to CO(2) during its growth phases, but its death did depend on it. An increase of CO(2) led to a significant improvement in G. candidum. Penicillium camemberti mycelium development was enhanced by 2% CO(2). The equilibrium between P. camemberti and G. candidum populations was disrupted in favor of the yeast when CO(2) was higher than 4%. Growth of B. aurantiacum depended more on O(2) than on CO(2). Two ripening progressions were observed in relation to the presence of CO(2) at the beginning of ripening: in the presence of CO(2), the ripening was fast-slow, and in the absence of CO(2), it was slow-fast. The underrind was too runny if CO(2) was equal to or higher than 6%. The nitrogen substrate progressions were slightly related to ripening chamber CO(2) and O(2) levels. During chamber ripening, the best atmospheric condition to produce an optimum between microorganism growth, biochemical dynamics, and cheese appearance was a constant CO(2) level close to 2%.
Evaluation of the tetracycline‐ and ecdysone‐inducible systems for expression of neurotransmitter receptors in mammalian cells (2001)

Establishing a stable cell line that expresses a particular protein of interest is often a laborious and time-consuming experience. With constitutive expression systems, a gradual loss of the highly expressing clones over a given time span and/or a severe counter-selection due to toxicity of the expressed protein for the host cell line are major drawbacks. In both cases, inducible expression systems offer a valuable alternative. Over the years, many regulated expression systems have been developed and evaluated. In the present study, we compare the efficiency, the advantages and the drawbacks of a tetracycline- and an ecdysone-inducible system for expression of the reporter protein chloramphenicol acetyltransferase and of different G-protein-coupled serotonin (5-HT) receptors. A high level of expression of different 5-HT receptors was obtained with the tetracycline-inducible system. In the cell line L929, which stably expresses the tetracycline-responsive transactivator, a maximum ligand binding of 20,000 and 9500 fmol/mg protein was measured for the h5-HT(1B) and h5-ht(1F) receptors, respectively. In the HEK293rtTA cell line, levels of 15,700, 3000, and 9100 fmol bound ligand/mg protein were obtained for the h5-HT(1B), h5-ht(1F) and h5-HT(4b) receptors, respectively. These high expression levels remained stable for several months of continuous culture. Although the ecdysone-inducible expression system was useful for tightly regulated expression, the levels were far lower than those obtained with the tetracycline system (e.g. 640 fmol bound ligand/mg protein for the h5-ht(1F) receptor in HEK293EcR).
Fibre metrology and physical characteristics of lambskins from large Merino and crossbred lambs (1997)

Summary. Two hundred and eighty-three lambskins were derived from the progeny of Merino (M), Texel (T), Poll Dorset (PD) and Border Leicester (BL) sires individually mated to Merino and Border Leicester × Merino (BLM) ewes giving 6 genotypes (M × M, T × M, PD × M, BL × M, T × BLM and PD × BLM). The lambs were shorn at 14 weeks and slaughtered (about 20 weeks later) at minimum carcass weights of 18 and 22 kg for ewe and cryptorchid sexes respectively. The ewe lambskins were fellmongered and the pelts processed to nappa, while the cryptorchids were processed to wool-on tannage. Comparative information on fibre metrology, skin mensuration, physical strength of the leather and commercial utility was collected. Skins from all genotypes had a surface area &gt;0.75 m2 and satisfactory physical properties. Pinhole was common amongst all genotypes, whereas ribbyness was largely a Merino trait. Ribbyness was associated with more frequent scarring from shearing damage and processing, indicating that Merino skins are least desirable for production of lamb nappa. The fine diameter and low medullation of Merino wool differed from all the other genotypes whose wool can be classed as industrial. After trimming to a 25 mm nap, lambskins of all genotypes were suitable for wool-on leather products. Skins from well managed lambs of all genotypes would be suitable as wool-on skins.
Some Information Age Techno‐Fallacies (2003)

In research on computer data bases, work and electronic location monitoring, telephone identification systems and drug testing 1 I encountered comments such as: “turn the technology loose and let the benefits flow”; “do away with the human interface”; “only the computer sees it”; “that has never happened”; “there is no law against this”; “the technology is neutral”. These are all examples of what can be termed information age techno‐fallacies . They are part of the cultural undergirding of routine data collection practices and an optimistic, techno‐surveillance worldview that is strongest in, but is hardly restricted to, the United States. They reflect a broader celebratory ethos of technology and commerce. To understand technologies for collecting personal information, we must understand the ideational environment in which they are nourished and in which they flourish. Before a surveillance technology is adopted, it is important to examine the broader cultural climate, the rationales for action and the accompanying empirical and value assumptions.
Hydrogen Peroxide Produced by Oral Streptococci Induces Macrophage Cell Death (2013)

Hydrogen peroxide (H2O2) produced by members of the mitis group of oral streptococci plays important roles in microbial communities such as oral biofilms. Although the cytotoxicity of H2O2 has been widely recognized, the effects of H2O2 produced by oral streptococci on host defense systems remain unknown. In the present study, we investigated the effect of H2O2 produced by Streptococcus oralis on human macrophage cell death. Infection by S. oralis was found to stimulate cell death of a THP-1 human macrophage cell line at multiplicities of infection greater than 100. Catalase, an enzyme that catalyzes the decomposition of H2O2, inhibited the cytotoxic effect of S. oralis. S. oralis deletion mutants lacking the spxB gene, which encodes pyruvate oxidase, and are therefore deficient in H2O2 production, showed reduced cytotoxicity toward THP-1 macrophages. Furthermore, H2O2 alone was capable of inducing cell death. The cytotoxic effect seemed to be independent of inflammatory responses, because H2O2 was not a potent stimulator of tumor necrosis factor-α production in macrophages. These results indicate that streptococcal H2O2 plays a role as a cytotoxin, and is implicated in the cell death of infected human macrophages.
“FIAT LUX” AND THE GENERATION OF THE SON: “Christ I”, 214–48 (1969)

“FIAT LUX” AND THE GENERATION OF THE SON: “Christ I”, 214–48 Get access THOMAS D. HILL THOMAS D. HILL Cornell UniversityIthaca, New York Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 16, Issue 7, July 1969, Pages 246-b–248, https://doi.org/10.1093/nq/16-7-246b Published: 01 July 1969
Analogue two-dimensional semiconductor electronics (2020)

Digital electronics are ubiquitous in the modern world, but analogue electronics also play a crucial role in many devices and applications. Analogue circuits are typically manufactured using silicon as the active material. However, the desire for improved performance, new devices and flexible integration has—as for their digital counterparts—led to research into alternative materials, including the use of two-dimensional (2D) materials. Here, we show that operational amplifiers—a basic building block of analogue electronics—can be created using the 2D semiconductor molybdenum disulfide (MoS2) as the active material. The device is capable of stable operation with good performance, and we demonstrate its use in feedback circuits including inverting amplifiers, integrators, log amplifiers and transimpedance amplifiers. We also show that our 2D platform can be used to monolithically integrate an analogue signal preconditioning circuit with a MoS2 photodetector.
Boundary layer and flow control: its principles and application (1961)

Boundary layer and flow control: its principles and application , Boundary layer and flow control: its principles and application , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Quantitative Analysis of Alveolar Type II Cell Tumors in Mice by Whole Lung Serial and Step Sections (1989)

Alveolar type II cell tumors were induced transplacentally by intraperitoneal injection of pregnant C3H/HeNCr MTV- or Swiss Webster mice with N-nitrosoethylurea at a dose of 0.5 mmol/kg and 0.74 mmol/kg. At different time points after birth (1-32 weeks), the entire lungs from 40 of the male offspring were inflated with Bouin's fixative, separated into lobes, and sectioned at 5 microns serially to detect every microscopic lesion. Results were compared with those obtained from examining only every 10th, 20th, or a single midlevel section from the same material. On average, 150 serial sections were prepared per mouse lung. Initially, only purely solid/alveolar or purely tubulopapillary types were observed but with tumor progression, papillary structures developed within solid tumors resulting in mixed neoplasms. Analyzing mouse lungs in step sections of every 10th section (50-60 microns), 5/238 (2%) of the tumors were missed, in step sections of every 20th section (100-120 microns), 16/238 (7%) of the tumors were not detected and usually less than half of the tumors were seen in the single mid-level section. The approximate size of the neoplasms is indicated by the total number of sections per tumor. The dimensions of tumors evaluated with step sections of 10 or 20 were comparable to the size observed with serial sections. It is concluded that the evaluation of mouse lung tumors in steps of approximately 50 microns is basically equivalent to the study of serial sections and appears to be a feasible method to assess the complete incidence, histological type, and size of all proliferative processes throughout the entire lung.
Polymeric Nanocomposite Membranes for Next Generation Pervaporation Process: Strategies, Challenges and Future Prospects (2017)

Pervaporation (PV) has been considered as one of the most active and promising areas in membrane technologies in separating close boiling or azeotropic liquid mixtures, heat sensitive biomaterials, water or organics from its mixtures that are indispensable constituents for various important chemical and bio-separations. In the PV process, the membrane plays the most pivotal role and is of paramount importance in governing the overall efficiency. This article evaluates and collaborates the current research towards the development of next generation nanomaterials (NMs) and embedded polymeric membranes with regard to its synthesis, fabrication and application strategies, challenges and future prospects.
Abstract GMM-029: MITOCHONDRIAL STRESS RESPONSE ADAPTATIONS ARE REQUIRED FOR OVARIAN CANCER ANCHORAGE-INDEPENDENT SURVIVAL AND METASTASIS (2019)

Abstract Late stage ovarian cancer is marked by poor patient survival and significant metastatic spread throughout the peritoneal cavity. During transcoelomic spread cells must adapt to survive anchorage-independence and to cope with stress associated with matrix detachment and the hostile environment of the ascites. Our findings demonstrate that an important ovarian cancer cell adaptation during anchorage-independence is the up-regulation of the mitochondrial stress response proteins, the mitochondrial antioxidant enzyme superoxide dismutase 2 (Sod2), and it's regulator, the nutrient and redox sensing deacetylase SIRT3. We show that these proteins are necessary for anchorage-independent cell survival and transcoelomic metastasis in vivo. In addition to Sod2's role as a mitochondrial superoxide scavenger, mechanistic data show that Sod2 shifts the redox landscape of cancer cells to a higher hydrogen peroxide (H2O2) steady-state. This novel non-canonical function of Sod2 results in H2O2-dependent oxidation and inactivation of phosphatases, including PTEN. Sod2/H2O2-dependent redox signaling may hence be a novel driver of anchorage-independent survival and an important contributor to the high frequency of Akt activation observed in metastatic ovarian cancers. While these sub-lethal increases in cellular H2O2 lead to pro-tumorigenic signaling, this also places cells closer to the cytotoxic threshold of H2O2, making cells with high Sod2 expression exquisitely sensitive to exogenous H2O2 application, and H2O2 generating agents, including high dose ascorbate. These findings provide an important clue to the vulnerability of Sod2 expressing cancer cells. Our findings also demonstrate that SIRT3 is an important regulator of Sod2 activity during anchorage-independence, which challenges previous studies demonstrating that SIRT3 is a tumor suppressor, and points to a novel pro-survival role for SIRT3 during ovarian cancer spread. Given that SIRT3 is sensitive to nutrient stress, this regulation has further consequences on the ability of ovarian cancer cells to survive potentially nutrient deprived tumor environments. Our study has identified two important mitochondrial stress response genes that are specifically increased in response to matrix detachment and required for anchorage independent survival and metastatic spread of ovarian cancer. Our ongoing studies are investigating their role in the context of redox and nutrient stress of ascites and targeting these stress adaptations for therapeutic intervention. Citation Format: Piyushi Gupta-Vallur, Yeon Soo Kim, Dong-Hui Shin, LP Madhubhani Hemachandra, Rebecca Phaeton, Karthikeyan Mythreye, and Nadine Hempel. MITOCHONDRIAL STRESS RESPONSE ADAPTATIONS ARE REQUIRED FOR OVARIAN CANCER ANCHORAGE-INDEPENDENT SURVIVAL AND METASTASIS [abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium; Sep 13-15, 2018; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2019;25(22 Suppl):Abstract nr GMM-029.
Detection of intracranial emboli in patients with symptomatic extracranial carotid artery disease. (1992)

The observed high frequency of silent embolism of the intracranial arteries detected by transcranial Doppler monitoring in patients with recurrently symptomatic extracranial carotid artery disease should encourage studies of the prognostic and therapeutic implications of this method.
Emissions from Syngas Combustion (2008)

Gasification technology has matured to the point that previously-held hesitations regarding performance and availability have given way to acceptance of the technology for energy generation. Indeed, the past few years have seen a significant increase in the number of gasifiers installed for generation of power and heat, and the number of installations is expected to increase dramatically over the next several decades as demand for efficient and environmentally sound energy generation increases. It is valuable to consider the environmental impact of this new generation of energy production systems, specifically release of gaseous emissions from combustion of the synthesis gas produced by gasification. Emissions from syngas combustion in turbines, engines and boilers are discussed in this review. The types of emissions considered include the unburned fuel components and partially oxidized species, nitrogen and sulfur-containing gases, volatile organic compounds, and other trace elements. Combustion of synthesis gas, in general, produces lower emissions for heat and power generation than conventional liquid and solid fuels. The composition of the syngas strongly influences the level of emissions. Hydrogen and carbon monoxide in synthesis gases results in elevated combustion temperature that facilitates the thermal formation of NO and NO2. In contrast, higher temperatures promote complete combustion and reduce the emission of organic volatiles, which are formed mainly from minor fractions of hydrocarbons in synthesis gases. Particulate matter, metallic compounds and other undesired pollutants are usually removed before firing synthesis gases for heat and power production. Therefore, integrated gasification and combined cycle systems are more environmentally friendly than conventional power generation systems.
Asthmatics Exhibit Altered Oxylipin Profiles Compared to Healthy Individuals after Subway Air Exposure (2011)

Several of the altered oxylipins have known or suspected bronchoprotective or anti-inflammatory effects, suggesting a possible reduced anti-inflammatory response in asthmatics following exposure to subway air. These observations may have ramifications for sensitive subpopulations in urban areas.