gebhart/patrepeval huggingface dataset:
Automatic control and detection systems for low-level radioactive waste drums (2020)

Vast quantities of low-level solid nuclear wastes are produced in the operation and decommissioning of nuclear facilities. These radioactive nuclear wastes are usually contained in special drums. Consequently, these nuclear waste drums must be tested, classified and their levels measured before they are placed in a final repository. There are certain dangers during the detection process; there is an urgent need for a safe, efficient, and autonomous system to inspect these nuclear waste drums. This study describes the methods involved in scanning and measuring the vertical section of radioactive waste drums and describes using the programmable logic controller (PLC-SIEMENS S7-1200) in order to construct an automated system as well as a detection system. According to the waste drum test flow, we designed a control program that utilizes the STEP7 Software as well as a monitoring program using SIEMENS WinCC that is flexible within the computer's central monitoring system. In the future, this system may be applied beyond the scale of a laboratory; nuclear enterprises may be able to adopt this process for sampling checks on contaminated waste. This study ensures the detection efficiency of waste drums as well as the safety of their operators. Furthermore, the proposed system effectively promotes the disposal and management of radioactive waste, which has potential applications in engineering.
Positive and Negative Modulation of Viral and Cellular mRNAs by Liver-specific MicroRNA miR-122 (2006)

microRNAs (miRNAs) are small RNAs that in general down-regulate the intracellular abundance and translation of target mRNAs. We noted that sequestration of liver-specific miR-122 by modified antisense oligonucleotides resulted in a dramatic loss of hepatitis C virus (HCV) RNA in cultured human liver cells. A binding site for miR-122 was predicted to reside close to the 5' end of the viral genome, and its functionality was tested by mutational analyses of the miRNA-binding site in viral RNA, resulting in reduced intracellular viral RNA abundance. Importantly, ectopic expression of miR-122 molecules that contained compensatory mutations restored viral RNA abundance, revealing a genetic interaction between miR-122 and the viral RNA genome. Studies with replication-defective viral RNAs demonstrated that miR-122 affected mRNA abundance by positively modulating RNA replication. In contrast, interaction of miR-122 with the 3'-noncoding region (3'NCR) of the cellular mRNA encoding the cationic amino acid transporter CAT-1 resulted in the down-regulation of CAT-1 protein abundance. These findings provide evidence that a specific miRNA can regulate distinct target mRNAs in both a positive and negative fashion. The positive role of miR-122 in viral replication suggests that this miRNA could be targeted for antiviral therapy.
Angular dependence of the reflectance from an isotropic polydomain medium: the influence of absorption (2005)

The angular dependence of the reflectance from an absorbing randomly oriented polydomain medium consisting of domains either small or large compared with the wavelength is investigated. Besides the two conventional cases, where the refractive index of the incidence medium is either smaller or larger than the averaged index of refraction (small-domain limit) or every principal index of refraction of the domains (large-domain limit), we also discuss a third principal case, which exists only in the large-domain limit. In this third case, only one of the principal indices of refraction is larger than that of the incidence medium, while the averaged index of refraction is smaller. Thus, in contrast to the small-domain limit, total reflection is completely suppressed even in the absence of absorption. A characteristic property of such a polydomain medium is its ability to considerably depolarize linear polarized light in spite of being optically isotropic. Additionally, the parallel polarized reflectance Rp can exceed the perpendicular polarized reflectance Rs over certain angle of incidence ranges. Absorption decreases these domain-size-dependent properties, even under the assumption of constant anisotropy. Nevertheless, for materials with low absorption indices, these effects can affect the optical properties significantly.
High efficiency optoelectronic terahertz sources (2010)

We have developed a new generation of optoelectronic large bandwidth terahertz sources based on TEM horn antennas monolithically integrated with several types of photodetectors: low-temperature grown GaAs (LTG-GaAs) planar photoconductors, vertically integrated LTG-GaAs photoconductors on silicon substrate and uni-travelling-carrier photodiodes. Results of pulsed (time-domain) and photomixing (CW, frequency domain) experiments are presented.
Microelectromechanical structures for multi-axial fatigue testing (2013)

Recent advances in micromachine devices have increased the need for information about the dynamic material behavior at scales relevant to microelectromechanical systems (MEMS).However, the present understanding of fatigue at MEMS scales is relatively sparse.The review of the literature indicates that there is a significant scatter in the fatigue strength of silicon, the basic structural material of MEMS.In addition, most of the previous work has been performed with very simple devices that do not simulate fatigue under multiaxial loading conditions, similar to those occurring during micromachine operation.The aim of this publication, therefore, is to introduce novel microstructures, fabricated by standard surface micromachining, that enable fatigue testing under conditions typical of most MEMS devices.Cyclic loading is generated by interdigitized comb drives, arranged along radial "spokes" extending from a suspended ring held in place by thin flexures (fatigue specimens) attached to an anchor at the center of the device.The test structures are excited at resonance using on-chip actuation to generate the forces required to produce fatigue damage.The fabrication process for obtaining such microstructures and preliminary results from fatigue experiments performed at atmospheric conditions are presented and discussed in the context of damage accumulation in polycrystalline silicon microstructures subjected to cyclic loading.
HgCdTe APDs detector developments at CEA/Leti for atmospheric lidar and free space optical communications (2019)

HgCdTe APD detector modules telecommunication are developed at CEA/Leti for atmospheric LIDAR and free space optical (FSO). The development is driven by the design and manufacture of generic sub-assemblies that can be adapted in each detector module to meet the specific detector requirements of each application. The optimization of such subassemblies is detailed in perspective of the challenges that are set by the specifications for detector modules currently developed for atmospheric LIDAR, in the scope of an R&amp;T CNES project for Airbus and an H2020 project HOLDON, and FSO, in the scope of an ESA project and in collaboration with Mynaric Lasercom GmbH. Two detector modules have recently been delivered to Airbus DS for extensive LIDAR simulation tests. Initial characterization of these modules shows that the input noise, NEP=10-15fW/&radic;Hz (5 photons rms) have been reduced by a factor three compared to previously developed large area detectors although the bandwidth have been increased to 180 MHz in order to respond to the requirements of high spatial depth resolution. The temporal remanence was 10<sup>-4</sup> at 200 ns after the detection of short light impulse, which is compatible with demanding LIDAR applications such as bathymetric profiling.
OMI-DL: An Ontology Matching Framework (2015)

This paper focuses on matching ontologies created for similar domains through different sources. Different solutions use lexical, structural or logical processing and analysis to match ontologies. However, an important aspect is also interpreting concepts that entities are presented with and using them in relation to semantics in an ontology. The paper demonstrates analyzing and extending the concepts used to define entities in an ontology, discusses establishing and filtering matching candidates by reasoners, and then describes constructing correspondences between entities from different ontologies using lexical and semantic analysis. The experiments show that our prototype, called OMI-DL, is among the top group over many ontologies adopted from the OAEI benchmark data set. We also provide an evaluation of the OMI-DL method for matching the DOLCE+DnS Ultralite ontology and the domain ontology developed in the m:Ciudad project.
Grazing incidence small-angle x-ray scattering from defects induced by helium implantation in silicon (2006)

The formation and growth of defects, including nanocavities and extended interstitial-type defects, created by helium implantation in silicon (50keV, 7.1015cm−2) in the temperature range of 100–550°C has been investigated by grazing incidence small-angle x-ray scattering. We show that quantitative information can be obtained on the size distribution, shape dispersion (i.e., anisotropy and faceting versus the size), and depth profile of the nanocavities from the near surface to deeply buried regions up to 1μm. It is thus demonstrated that low temperature implantations (⩽200°C) lead to the formation of spherical nanocavities with a heterogeneous depth distribution whereas implantations at high temperatures (⩾300°C) cause growth of the cavities, broadening of the size distribution, and size-dependent faceting leading to a size-dependent shape anisotropy. Furthermore, we show that the method allows to characterize the morphology (i.e., width and thickness) and the evolution of extended planar {113} defects created during the implantation process at high temperatures.
ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI) (2021)

NCT0405269.
Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia (2005)

Ammonia is an abundant fermentation product in the forestomachs of ruminants and the intestine of other species. Uptake as NH3 or NH4+ should modulate cytosolic pH and sodium-proton exchange via Na+/H+ exchanger (NHE). Transport rates of Na+, NH4+, and NH3 across the isolated rumen epithelium were studied at various luminal ammonia concentrations and pH values using the Ussing chamber method. The patch-clamp technique was used to identify an uptake route for NH4+. The data show that luminal ammonia inhibits electroneutral Na transport at pH 7.4 and abolishes it at 30 mM (P < 0.05). In contrast, at pH 6.4, ammonia stimulates Na transport (P < 0.05). Flux data reveal that at pH 6.4, approximately 70% of ammonia is absorbed in the form of NH4+, whereas at pH 7.4, uptake of NH3 exceeds that of NH4+ by a factor of approximately four. The patch-clamp data show a quinidine-sensitive permeability for NH4+ and K+ but not Na+. Conductance was 135 +/- 12 pS in symmetrical NH(4)Cl solution (130 mM). Permeability was modulated by the concentration of permeant ions, with P(K) > P(NH4) at high and P(NH4) > P(K) at lower external concentrations. Joint application of both ions led to anomalous mole fraction effects. In conclusion, the luminal pH determines the predominant form of ammonia absorption from the rumen and the effect of ammonia on electroneutral Na transport. Protons that enter the cytosol through potassium channels in the form of NH4+ stimulate and nonionic diffusion of NH3 blocks NHE, thus contributing to sodium transport and regulation of pH.
Supplementary Table 1 from Diverse <i>BRAF</i> Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity (2023)

&lt;p&gt;Supplementary Table 1. KSEA kinase scores and kinase-substrate links identified in phosphoproteomic screen (provided separately due to size)&lt;/p&gt;
Headphone Filtering in Spectral Domain (2019)

The hearing profile of each individual is as unique as a fingerprint, someone might like more bass, some may prefer more midrange, while others like detailed high frequency information. Listening to audio in an acoustically treated room is the closest we can get to a perfect listening experience. Since this research concentrates on headphones, the room factor will not be influencing the listening experience. Therefore, it could be a useful tool for professionals, to have the headphones sound as linear as they can be and to find out analytically, if they are preferred with the implemented filter sets over their default response. This study will also look to move in the direction of establishing a standard that can be used as reference for measuring headphone performance.
Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus (2015)

The discovery of African henipaviruses (HNVs) related to pathogenic Hendra virus (HeV) and Nipah virus (NiV) from Southeast Asia and Australia presents an open-ended health risk. Cell receptor use by emerging African HNVs at the stage of host-cell entry is a key parameter when considering the potential for spillover and infection of human populations. The attachment glycoprotein from a Ghanaian bat isolate (GhV-G) exhibits <30% sequence identity with Asiatic NiV-G/HeV-G. Here, through functional and structural analysis of GhV-G, we show how this African HNV targets the same human cell-surface receptor (ephrinB2) as the Asiatic HNVs. We first characterized this virus-receptor interaction crystallographically. Compared with extant HNV-G-ephrinB2 structures, there was significant structural variation in the six-bladed β-propeller scaffold of the GhV-G receptor-binding domain, but not the Greek key fold of the bound ephrinB2. Analysis revealed a surprisingly conserved mode of ephrinB2 interaction that reflects an ongoing evolutionary constraint among geographically distal and phylogenetically divergent HNVs to maintain the functionality of ephrinB2 recognition during virus-host entry. Interestingly, unlike NiV-G/HeV-G, we could not detect binding of GhV-G to ephrinB3. Comparative structure-function analysis further revealed several distinguishing features of HNV-G function: a secondary ephrinB2 interaction site that contributes to more efficient ephrinB2-mediated entry in NiV-G relative to GhV-G and cognate residues at the very C terminus of GhV-G (absent in Asiatic HNV-Gs) that are vital for efficient receptor-induced fusion, but not receptor binding per se. These data provide molecular-level details for evaluating the likelihood of African HNVs to spill over into human populations.
Critical Role of Different Immobilized Biocatalysts of a Given Lipase in the Selective Ethanolysis of Sardine Oil (2016)

Different immobilized derivatives of two lipases were tested as catalysts of the synthesis of ethyl esters of omega-3 fatty acids during the ethanolysis of sardine oil in solvent-free systems at 25 °C. Lipases from Thermomyces lanuginosus (TLL) and Lecitase Ultra (a phospholipase with lipolytic activity) were studied. Lipases were adsorbed on hydrophobic Sepabeads C18 through the open active center and on an anion-exchanger Duolite with the active center exposed to the reaction medium. TLL-Sepabeads derivatives exhibit a high activity of 9 UI/mg of immobilized enzyme, and they are 20-fold more active than TLL-Duolite derivatives and almost 1000-fold more active than Lipozyme TL IM (the commercial derivative from Novozymes). Lecitase-Sepabeads exhibit a high selectivity for the synthesis of the ethyl ester of EPA that is 43-fold faster than the synthesis of the ethyl ester of DHA.
J. Briard Les mégalithes de l'Europe atlantique. Architecture et art funéraire (5000 à 2000 avant J.-C.) (1996)

Masset Claude. J. Briard Les mégalithes de l'Europe atlantique. Architecture et art funéraire (5000 à 2000 avant J.-C.). In: Bulletin de la Société préhistorique française, tome 93, n°1, 1996. pp. 14-15.
Evaluation of a modified autocorrelation method when applied to cardiac strain rate imaging (2006)

When estimating tissue velocities using the con- ventional autocorrelation method (AM), the ultrasound center frequency is assumed constant and equal to the demodulation frequency, while in the modified autocorrelation method (MAM) the former is continuously estimated together with the phase shift from pulse to pulse. The AM is unbiased only if the demodulation frequency is equal to the received center frequency. This assumption is not necessarily valid. The purpose of this work has been to evaluate the performance of the MAM compared to the AM, when applied to cardiac strain rate estimation. Both methods have been implemented and evaluated in two different environments; simulated RF-data from an analytic model of the human heart and experimental data acquired from human hearts scanned with a specially programmed Vivid 7 scanner (GE Vingmed Ultrasound). When applied to simulated RF-data, the MAM demonstrated superior performance with respect to estimator variance and bias. Both methods displayed a high degree of correlation with the true strain rate of the analytic model. When estimating strain rate using experimental data, a previously presented spectral strain rate method was used as a reference. In this case the MAM did not show superior performance. On the contrary, the AM demonstrated a lower estimator variance and bias compared to the MAM.
Endothelial cell SHP‐2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM‐1–VE‐cadherin interaction (2017)

Intercellular adhesion molecule-1 (ICAM-1) mediates the firm adhesion of leukocytes to endothelial cells and initiates subsequent signaling that promotes their transendothelial migration (TEM). Vascular endothelial (VE)-cadherin plays a critical role in endothelial cell-cell adhesion, thereby controlling endothelial permeability and leukocyte transmigration. This study aimed to determine the molecular signaling events that originate from the ICAM-1-mediated firm adhesion of neutrophils that regulate VE-cadherin's role as a negative regulator of leukocyte transmigration. We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2), and SHP-2 down-regulation <i>via</i> silencing of small interfering RNA in endothelial cells enhanced neutrophil adhesion to endothelial cells but inhibited neutrophil transmigration. We also found that VE-cadherin associated with the ICAM-1-SHP-2 complex. Moreover, whereas the activation of ICAM-1 leads to VE-cadherin dissociation from ICAM-1 and VE-cadherin association with actin, SHP-2 down-regulation prevented ICAM-1-VE-cadherin association and promoted VE-cadherin-actin association. Furthermore, SHP-2 down-regulation <i>in vivo</i> promoted LPS-induced neutrophil recruitment in mouse lung but delayed neutrophil extravasation. These results suggest that SHP-2-<i>via</i> association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their TEM.-Yan, M., Zhang, X., Chen, A., Gu, W., Liu, J., Ren, X., Zhang, J., Wu, X., Place, A. T., Minshall, R. D., Liu, G. Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction.
Aspergillus Pancarditis and Cardiac Arrest during Anesthesia (1981)

Department of Anesthesiology, Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York 10467. *Assistant Professor of Anesthesiology, Albert Einstein College of Medicine, and Adjunct Attending Anesthesiologist, Montefiore Hospital and Medical Center. †Professor of Anesthesiology, Albert Einstein College of Medicine, and Chairman, Department of Anesthesiology, Montefiore Hospital and Medical Center. ‡Instructor of Anesthesiology, Albert Einstein College of Medicine, and Assistant Attending Anesthesiologist, Montefiore Hospital and Medical Center. Reprint requests to Dr. Kaplan. Accepted for publication February 3, 1981.
Pneumatic delivery of untethered microgrippers for minimally invasive biopsy (2017)

The surgical biopsy is one of the most widely utilized medical procedures for diagnosis of a number of diseases. In order to enable less invasive biopsies, we have previously developed and applied residual stress and physiologically activated sub-millimeter sized untethered grippers. Here, we report a controlled, pneumatic system and methodology for pressurized delivery of untethered microgrippers (μ-grippers) to improve the efficacy of tissue excision. The approach is compatible with current minimally invasive laparoscopic and endoscopic methods. Using a model experimental system, we observed that pneumatic delivery significantly improves the efficiency of the tissue attachment-μ-grippers attach up to 30-fold better on vertically oriented tissues, and up to 3.5-fold better on horizontally oriented tissues as compared to experiments without pressurized delivery. Hence, the use of pneumatics in the delivery of untethered microdevices could significantly enhance their efficiency in minimally invasive biopsy procedures.
Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23→q25 (1991)

Insulin-degrading enzyme (IDE) is a cytosolic proteinase involved in the cellular processing of insulin. Using somatic cell hybrid analysis and in situ chromosomal hybridization, we have localized the gene encoding IDE to human chromosome 10, bands q23----q25. The murine Ide gene was previously mapped to Chromosome 19; together, these results suggest that the IDE gene is a member of a conserved syntenic group on human chromosome 10, bands q23----q25 and mouse Chromosome 19.
2020 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 38th Annual Report (2021)

These data support the continued value of PC expertise and need for specialized medical toxicology information to manage more serious exposures. Unintentional and intentional exposures continue to be a significant cause of morbidity and mortality in the US. The near real-time status of NPDS represents a national public health resource to collect and monitor US exposure cases and information contacts. The continuing mission of NPDS is to provide a nationwide infrastructure for surveillance for all types of exposures (e.g., foreign body, infectious, venomous, chemical agent, or commercial product), and the identification and tracking of significant public health events. NPDS is a model system for the near real-time surveillance of national and global public health.
Procedimiento de caracterización y clasificación de cálculos renales (2012)

Procedimiento de caracterizacion y clasificacion de calculos renales, que comprende las siguientes etapas:(a) se toman una pluralidad de muestras de calculos renales y se cortan para observar su interior, obteniendo una superficie lo mas plana posible, (b) se aplica la tecnica de Formacion de Imagenes Hiperespectrales (HSI) obteniendo los espectros de los calculos renales anteriormente cortados, seleccionando una pluralidad de Regiones de Interes (ROI) y analizando la imagen a traves de Analisis de Componentes Principales (PCA)(c) se identifican las especies principales mediante Analisis de Factores (FA)(d) se identifican valores atipicos a traves de Analisis de Componentes Principales (PCA)(e) se analizan los diferentes tipos de calculos renales a traves de un Analisis de Componentes Principales (PCA)(f) a los datos obtenidos del Analisis de Componentes Principales (PCA) se aplica la tecnica de Redes Neuronales Artificiales (ANN) para su clasificacion.