gebhart/patrepeval huggingface dataset:
Interleukin-6, CD45 and the Src-Kinases in Myeloma Cell Proliferation (2003)

AbstractMultiple myeloma (MM) is a proliferative disorder of monoclonal plasma cells which accumulate in human bone marrow, and myeloma cells proliferate in response to a cytokine, interleukin-6 (IL-6). We recently found that MPC-1−CD49e− immature myeloma cells expressing CD45 form a proliferating population in MM. IL-6 activates at least two intracellular pathways including signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase 1/2 (ERK1/2) following the activation of Janus kinases (JAKs) via its receptor complexes composed of the IL-6 receptor α chain and gp130. Although the roles of CD45 have been extensively studied for antigen receptors in B and T cells, its physiological consequences in other hematopoietic cells remain largely unknown. Myeloma cells expressing CD45 antigens which contain the activation of src family protein-tyrosine kinases (PTKs) independent of IL-6 stimulation proliferate in response to IL-6, whereas the proliferation of CD45 cells which lack a considerable activity of the src family PTKs is not promoted by IL-6. The STAT3 and ERK1/2 pathways are similarly activated by IL-6 in both cells either expressing or not expressing CD45. In this review, we argue a novel mechanism of proliferation of myeloma cells, in that the activation of both STAT3 and ERK1/2 is not sufficient for IL-6-induced proliferation which further requires IL-6-independent activation of the src family kinases associated with CD45 phosphatase. We propose that the cellular context, such as CD45 expression and src family kinase activation, is crucial for myeloma cells to proliferate in response to IL-6.Key Words: Multiple myelomaInterleukin-6CD45Src kinases
SOFTWARE‐DEFINED ENVIRONMENTS (2021)

Software-defined environments (SDEs) bring together software-defined compute, network, and storage and unify the control and management planes from each individual software-defined component. This chapter provides an overview of the vision, architecture, and current incarnation of SDEs within industry. The unified control plane dynamically constructs, configures, continuously optimizes, and proactively orchestrates the mapping between the workload and the resources based on the desired outcome specified by the workload and the operational conditions of the cloud environment. The chapter also demonstrates at a high level how this architecture achieves agility, efficiency, and continuous outcome optimized infrastructure with proactive resiliency and security. The overall framework on continuous assurance of resiliency is directly related to the continual optimization of the services performed within the SDEs, taking into account the value created by the delivery of service, subtracting the cost for delivering the service and the cost associated with a potential failure due to unavailability of the service.
Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40 (1999)

Simian virus 40 (SV40), a non-enveloped DNA virus, is transported from the cell surface to the nucleus where virus replication occurs. This pathway of virus uptake involves binding to surface MHC class I molecules, entry via non-coated pits, and subsequent transport to the endoplasmic reticulum (ER). At some stage in this pathway the virus must cross a membrane to reach the cytosol. In the present review, the cellular machinery which the virus has utilized to enter the cell will be examined. In particular, we will consider recent evidence for the involvement of caveolae in the infectious entry step and propose a model involving recruitment of caveolar proteins around the membrane-bound virus. We also speculate that a similar mechanism may have been exploited by bacterial pathogens. The subsequent steps by which SV40 reaches the ER remain unclear but recent evidence suggests that this pathway may be shared with several other proteins that are transported from surface caveolae to the ER.
Bacoside A: Role in Cigarette Smoking Induced Changes in Brain (2015)

Cigarette smoking (CS) is a major health hazard that exerts diverse physiologic and biochemical effects mediated by the components present and generated during smoking. Recent experimental studies have shown predisposition to several biological consequences from both active and passive cigarette smoke exposure. In particular, passive smoking is linked to a number of adverse health effects which are equally harmful as active smoking. A pragmatic approach should be considered for designing a pharmacological intervention to combat the adverse effects of passive smoking. This review describes the results from a controlled experimental condition, testing the effect of bacoside A (BA) on the causal role of passive/secondhand smoke exposure that caused pathological and neurological changes in rat brain. Chronic exposure to cigarette smoke induced significant changes in rat brain histologically and at the neurotransmitter level, lipid peroxidation states, mitochondrial functions, membrane alterations, and apoptotic damage in rat brain. Bacoside A is a neuroactive agent isolated from Bacopa monnieri. As a neuroactive agent, BA was effective in combating these changes. Future research should examine the effects of BA at molecular level and assess its functional effects on neurobiological and behavioral processes associated with passive smoke.
FSH-Rezeptor Mutation als Ursache für spontanes Überstimmulationssyndrom mit Abortinduktion und erfolgreicher 2. Schwangerschaft – Fallbericht einer erfolgreichen Schwangerschaft nach vorausgegangener Abortinduktion bei spontanem OHSS III in der 15 SSW (2008)

Das ovarielle Überstimulationssyndrom (OHSS) wird in der Regel als eine iatrogene Komplikation in der Reproduktionsmedizin angesehen. In seltenen Fällen kann das OHSS auch mit einem spontanen ovariellen Zyklus assoziiert sein, meistens in Zusammenhang mit multiplen Gestationen, Hypothyreose oder dem PCO-Syndrom. Erfahrungen über Schwangerschaften (SS) nach spontanem OHSS (sOHSS) sind bisher nicht berichtet worden.
Donor, Recipient, and Operative Factors Associated With Increased Endothelial Cell Loss in the Cornea Preservation Time Study (2018)

Donor diabetes, lower screening ECD, a PACE diagnosis in the recipient, and operative complications were associated with lower ECD at 3 years after DSAEK surgery and may be associated with long-term graft success. While causation cannot be inferred, further studies on the association of donor diabetes and PACE in recipients with lower 3-year ECD warrant further study.
Generation of Intense Low-Frequency Collimated Sound Beams by Nonlinear Acoustics and Detection by a Millimeter-Wave Vibrometer (2010)

Abstract : In this work, we designed, developed and tested nonlinear ultrasonic arrays for the purpose of generating an intense, collimated beam of sound to be directed at targets such as buried landmines. In order to make a completely noncontacting system, with insonification via the nonlinear array, we also developed a sensitive millimeter wave vibrometer to detect the resulting ground motion.
Shot Line Geometric Description Method for Aircraft Vulnerability Calculation (2009)

This article, firstly, categorizes aircraft's presented area in a particular hit aspect into non-vulnerable region, non-overlapping vulnerable region and overlapping vulnerable region. Then, the aircraft's unique existing states are divided into kill states, intermediate states and no kill states. The parameters pertinent to aircraft's existing states in the above-mentioned regions are analyzed by using the shot line scanning method. Finally, the method provides two kinds of shot line geometric descriptive data: component's vulnerable area and presented area in each region, which can be used to calculate the component's single-hit vulnerability and aircraft's unique existing states and the areas corresponding to each state, which can be used to calculate the aircraft's single-hit and multi-hit vulnerability. Examples show that the proposed method can provide the parameters of the aircraft's or its component's area under threat being hit through tracing the shot line path thereby enabling the vulnerability calculated results to conform with reality to larger extent. In addition, the method solves the generality problem in dealing with overlapping components.
High resolution, low energy avalanche photodiode X-ray detectors (1991)

Silicon avalanche photodiodes have been fabricated, and their performance as X-ray detectors has been measured. Photon sensitivity and energy resolution were measured as a function of size and operating parameters. Noise thresholds as low as 212 eV were obtained at room temperature, and backscatter X-ray fluorescence data were obtained for aluminum and other light elements. It is concluded that the results with the X-ray detector are extremely encouraging, and the performance is challenging the best available proportional counters. While not at the performance level of either cryogenic silicon or HgI/sub 2/, these devices operate at room temperature and can be reproduced in large numbers and with much larger areas than typically achieved with HgI/sub 2/. In addition, they are rugged and appear to be indefinitely stable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Regeneration of Capto™ Core 700 Resin through High Throughput and Laboratory Scale Studies and Impact on Production of a SARS-CoV-2 Vaccine Candidate (2022)

The biopharmaceutical industry is capable of rapid responses in the face of unprecedent challenges, such as the COVID-19 pandemic; safe and efficacious vaccines were developed in record times. However, additional hurdles, including raw materials shortages, need be overcome to improve further the industry’s agility. During the development of a SARS-CoV-2 vaccine candidate, such supply limitations necessitated the determination of a cleaning in place (CIP) strategy for a multimodal core-shell resin both rapidly and efficiently. This is a challenging task with its complexity depending on the nature of the resin and the composition of the feed stream. Here, we describe the deployment of high throughput (HT) techniques to screen CIP conditions for cleaning Capto™ Core 700 resin exposed to clarified cell culture harvest of a SARS-CoV-2 vaccine candidate produced in Vero adherent cell culture. The best performing conditions, comprised of 30% n-propanol and ≥0.75 N NaOH, were deployed in cycling experiments, completed with miniature chromatography columns, to demonstrate their effectiveness. The success of the CIP strategy was ultimately verified at laboratory scale. Here, its impact was assessed across the entire purification process which also included an ultrafiltration/diafiltration step. It is shown that the implementation of the CIP strategy enabled the re-use of the Capto Core 700 resin for up to ten cycles without any negative impact on the purified product. Hence, the strategic combination of HT and laboratory scale experiments can lead rapidly to robust CIP procedures, even for a challenging to clean resin, and thus help to overcome supply shortages.
Steep Subthreshold Slope below 60mV/dec in Junctionless SOI Transistors at Low Drain Voltage of 50mV (2019)

In this paper, we report steep subthreshold slope (SS) below 60mV/dec injunctionless SOI transistor at low drain voltage of 50mV, where the impact ionization (II) is negligible. The observed SS is 36mV/dec. The relationship among SS, drain voltage, hysteresis, scanning speed, and back bias is shown and the origin of steep SS is discussed.
ELECTRONIC SPECTRA OF TRANSITION METAL IONS IN CRYSTALS (1959)

This report includes: OPTICAL SPECTRA OF TRANSITION METAL IONS IN CORUNDUM, by Donald S. McClure. 1961, 67p. illus. OP ICAL SPECTRA OF Ni++, Co++, and Cu++ IN TE RAHEDRAL SITES IN CRYSTALS, by Herbert A. Weakliem. 1961, 47p. illus. tables. THE OPTICAL ABSORPTION SPECTRUM OF NiSiF6.6H2O, by Donald S. McClure. 1961, 14p. illus. table. EXCHANGE COUPLED Mn++ IONS IN ZnS SINGLE CRYSTALS, by Donald S. McClure. 1961, 11p. illus. tables.
All-cavity-driven cw ringdown spectrometer with regulation of intracavity Doppler frequency shifts (2007)

This paper presents a new design of all-cavity-driven cw-CRDS to minimize the problem of cavity Doppler shift, as well as a firm theoretical background for the ringdown signal formation. The cavity output signal is modeled analytically, and a close inspection of the resulting expression reveals the clear evidence for the absence of intensity modulation. The intracavity Doppler shift is shown to occur only within the duration of cavity length excursion, terminating before the onset of a ringdown transient. Thus the only spectral influence is expected to be the frequency shift of an absorption feature, preserving its lineshape. The amount of frequency shift is shown to be determined by the cavity excursion distance, which directly indicates the condition required for the minimal Doppler shift.
Genetic Susceptibility to Tobacco Carcinogenesis (1999)

Lung cancer risk is thus defined by the balance between metabolic activation and detoxification of xenobiotic compounds and by the efficiency of DNA repair. It is most likely that multiple susceptibility factors must be accounted for to represent the true dimensions of gene-environment interactions. The ability to identify smokers with the highest risks of developing cancer has substantial preventive implications. These subgroups could be targeted for the most intensive screening and smoking cessation interventions and could be enrolled into chemoprevention trials. Studying susceptibility to common cancers and widely prevalent exposures may provide further insights into the basic mechanisms of carcinogenesis. Issues that will need to be addressed in the very near future include risk communication to study subjects and the ethical, legal, and social consequences of such testing.
Enhancing Effects of Supernatants from Various Cultures of Bacillus thuringiensis on Larvicidal Activity of &delta;-Endotoxin against the Common Cutworm, Spodoptera litura (1995)

The synergistic effects of supernatants from cultures of nine strains of Bacillus thuringiensis toward the insecticidal activity of δ-endotoxin were investigated using neonates of the common cutworm, Spodoptera litura, and late 3rd instar larvae of the diamondback moth, Plutella xylostella by the diet incorporation method. Synergistic effects between supernatants and δ-endotoxins were detected against S. litura but not toward P. xylostella. Synergistic activity in supernatants against S. litura but not toward P. xylostella. Synergistic activity in supernatants against S. litura was observed in four strains and the occurrence was shown to be dependent on culture media. Interestingly, B. thuringiensis serovar japonensis strain Buibui and B. thuringinensis serovar morrisoni strain san diego, which produce insecticidal crystal proteins specific only to coleopteran larvae, were shown to produce synergistic factor(s) in culture supernatants. The synergistic substance(s) released into supernatants from various strains of B. thuringiensis were apparently the same.
Rendészet a szocializmus első évtizedeiben (2022)

Ma több mint három évtizede, hogy magunk mögött hagytuk a szocializmust, amely időszakban a történelem, így a szakmatörténet oktatása, kutatása sokszor tabutéma volt. Ezért is fontos, hogy a meglévő levéltári, könyvészeti forrásokra alapozva, a még élő tanúkat meghallgatva, felkutassuk a szocializmus alatt megvalósult rendészetet. A második világháború után szinte a teljes rendészeti elitet kicserélték, vagy eltávoztak önként a testülettől. Az ismert történelmi okok miatt a rendészetben is a szovjet modell átvétele kötelező volt, s meg is valósult mind módszerben, mind jelképesen, pl. az egyenruhák, rendfokozatok tekintetében. A szakemberhiány pótlására gyorsított tisztképzéssel válaszoltak, és csak a hatvanas évek végére sikerült hatékonyabb, magasabb színvonalú tisztképzés megvalósítani, ami elvezett a Rendőrtiszti Főiskola 1971-es létrehozásához. Az első rendőrségi törvényre 1955-ig kellett várni, míg a következő rendőrségi, rendészeti jogszabályok a hetvenes évek elején születtek meg.
An Opposed-Piston Diesel Engine (1993)

Typical conventional diesel engine designs are based on arrangements of single piston and cylinder sets placed sequentially either in-line or offset (“V”) along the crankshaft. The development of other engines, such as the opposed piston type, has been motivated by potential advantages seen in such designs, which may not be viable in conventional in-line or V engine arrangements. Several alternatives to conventional engine design have been investigated in the past and some aspects of these designs have been utilized by engine manufacturers. The design and development of a proof-of-concept opposed piston diesel engine is summarized in this paper. An overview of opposed-piston engines is presented from early developments to current designs. The engine developed in this work is a two stroke and uses four pistons, which move in two parallel cylinders that straddle a single crankshaft. A prechamber equipped with a single fuel injector connects the two cylinders, forming a single combustion chamber. The methodology of the engine development process is discussed along with details of component design. Experimental evaluations of the assembled proof-of-concept engine were used for determining feasibility of the design concept. An electric dynamometer was used to motor the engine and for loading purposes. The dynamometer is instrumented for monitoring both speed and torque. Engine parameters measured include air flow rate, fuel consumption rate, inlet air and exhaust temperatures, and instantaneous cylinder gas pressure as a function of crank position. The results of several testing runs are presented and discussed.
Early maximum extent of paleoglaciers from Mediterranean mountains during the last glaciation (2013)

Mountain glaciers respond directly to changes in precipitation and temperature, thus their margin extent is a high-sensitivity climate proxy. Here, we present a robust (10)Be chronology for the glacier maximum areal extent of central Spain paleoglaciers dated at 26.1 ± 1.3 ka BP. These glaciers reached their maximum extent several thousand years earlier than those from central Europe due to the increased precipitation within a cold period between 25 to 29 ka BP, as confirmed by a local speleothem record. These paleoclimate conditions impacted the maximum extent of mountain glaciers along the western and central Mediterranean region. The cause and timing of the enhanced precipitation implies a southward shift of the North Atlantic Polar Front followed by storm tracks in response to changes in insolation via orbital parameters modulation. Thus, these mountain paleoglaciers from the Mediterranean region record an ocean-continent climate interaction triggered by external forcing.
Palladium-Catalyzed Asymmetric 6-Endo Cyclization of Dienamides with Substituent-Driven Activation (2012)

Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents.
The Symmetry Property of a 90° Twisted Nematic Liquid Crystal Cell (1991)

Abstract A set of symmetry properties of a 90° twisted nematic (TN) cell under rotation of polarizers has been observed both cxpcrimentally and theoretically for the first time. These symmetry properties can he explained by an argument based on rotation and time reversal transformations. The use of these symmetry properties allows one to answer the long time puzzle as to whether the e-mode TN cell, in which the transmission axis of the entrance polarizer is parallel to the entrance rubbing direction, is superior to the o-mode TN cell, in which the transmission axis of the entrance polarizer is perpendicular to the entrance rubbing direction, for both normally white and normally black cases. In addition, these symmetry propertics provide us with a useful test for any existing TN LCD computer simulation program.
HIGH POWER BEAM-PLASMA AMPLIFIER (1964)

Abstract : Efficiency predictions obtained from the large signal computer theory are given. A Langmuir probe plasma mapping vehicle is described and results given. A coupling experiment showing 20 db of coupling enhancement due to the plasma is disucssed and the design of a second amplifier tube presented.
Effects of a Highway Improvement Project on Florida key Deer (2007)

With an absence of predators, deer-vehicle collisions (DVCs) are the primary source of mortality for the endangered Florida Key deer (Odocoileus virginianus clavium). Of these collisions, &amp;gt;50% occur on United States Highway 1 (US 1), the primary inter-island roadway in the Florida Keys. DVCs on the 5.6-km section of US 1 on Big Pine Key (BPK) are responsible for approximately 26% of annual mortality. In 2002, a continuous 2.6-km system of 2.4-m fencing, 2 underpasses, and 4 experimental deer guards was completed on US 1 on BPK. Our objective for this project was to evaluate the effectiveness of this system in reducing DVCs. Deer heavily used the underpasses built in the fenced area all 3 post-project years (2003–2005). The fencing successfully prevented Key deer from entering the exclusion area. In spite of increasing deer population numbers, the US 1 improvement project prevented an increase in DVCs on US 1.
Clustering of Variables for Mixed Data (2016)

This chapter presents clustering of variables which aim is to lump together strongly related variables. The proposed approach works on a mixed data set, i.e. on a data set which contains numerical variables and categorical variables. Two algorithms of clustering of variables are described: a hierarchical clustering and a k-means type clustering. A brief description of PCAmix method (that is a principal component analysis for mixed data) is provided, since the calculus of the synthetic variables summarizing the obtained clusters of variables is based on this multivariate method. Finally, the R packages ClustOfVar and PCAmixdata are illustrated on real mixed data. The PCAmix and ClustOfVar approaches are first used for dimension reduction (step 1) before applying in step 2 a standard clustering method to obtain groups of individuals.
10 Years-Activities at Onera on Advanced Thermal Barrier Coatings (2011)

Developing thermal barrier coatings operating at higher temperature and/or for very long durations (commercial aircraft applications) is one of the technological and economic challenges for engine manufacturers. This includes the search for (i)low thermal conductivity, high thermal stability and CMAS resistant ceramic top coats, and (ii)alternative low cost bond coats with improved oxidation resistance and chemical compatibility with the substrate. This paper reviews the rationale supporting the choice of new materials for each layer and presents some recommendations to develop more robust and more efficient systems with increased lifetime.
Hough Transform For Vehicle Identification (2005)

This paper describes a vision based vehicle identification algorithm. This algorithm has been developed using image processing and pattern recognition techniques. The paper describes the role of the image processing techniques in this algorithm, specifically, the application of the Hough Transform in this scheme.