gebhart/patrepeval huggingface dataset:
Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA ‡ multicenter study (2023)

Abstract Background Heterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative analyses of complementary multi-omics data obtained after the diagnosis of T1D may provide mechanistic insight into the diverse rates of disease progression. Methods We collected samples in a pan-European consortium that enabled the concerted analysis of five different omics modalities in data from 97 newly diagnosed patients. In this study we used Multi-Omics Factor Analysis to identify molecular signatures correlating with post-diagnosis decline in β-cell mass measured as fasting C-peptide. Results Two molecular signatures were significantly correlated with fasting C-peptide levels. One signature showed a correlation to neutrophil degranulation, cytokine signaling, lymphoid and non-lymphoid cell interactions and G-protein coupled receptor signaling events that were inversely associated with rapid decline in β-cell function. The second signature was related to translation and viral infection were inversely associated with change in β-cell function. In addition, the immunomics data revealed a Natural Killer cell signature associated with rapid β-cell decline. Conclusion Features that differ between individuals with slow and rapid decline in β-cell mass could be valuable in staging and prediction of the rate of disease progression and thus enable smarter (shorter and smaller) trial designs for disease modifying therapies, as well as offering biomarkers of therapeutic effect. Funding This work is funded by the Innovative Medicine Initiative 2 Joint Undertaking (IMI2 JU) under grant agreement N° 115797 (INNODIA) and N° 945268 (INNODIA HARVEST). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation program and ‘EFPIA’, ‘JDRF’ and ‘The Leona M. and Harry B. Helmsley Charitable Trust’.
Liquid-chromatographic analysis for methylphenidate (Ritalin) in serum. (1979)

We describe a "high performance" liquid chromatographic method for quantitating methylphenidate in serum. The internal standard, 4,5-diphenylimidazole, and serum or plasma sample are extracted in chloroform, evaporated, and redissolved in 20 mmol/L potassium phosphate (pH 3.5)/high-purity acetonitrile, 80/20 by vol. A centrifuged aliquot is chromatographed on mu-Bondapak C-18 with the phosphate/acetonitrile solvent as mobile phase, a flow rate of 1.6 mL/min, and a column temperature of 40 degrees C. Absorbances are read at 192 nm. This method reliably measures concentrations greater than 20 micrograms/L and has analytical recoveries of 74%.
Associations of Independent IL2RA Gene Variants with Intermediate Uveitis (2015)

We found rs11594656 and rs12722495 to be associated with intermediate uveitis but not with HLAB27 acute anterior uveitis. The genetic heterogeneity found at the IL2RA locus could help explain patterns of concomitance with other autoimmune diseases.
Weakly supervised semantic segmentation with a multi-image model (2011)

We propose a novel method for weakly supervised semantic segmentation. Training images are labeled only by the classes they contain, not by their location in the image. On test images instead, the method predicts a class label for every pixel. Our main innovation is a multi-image model (MIM) - a graphical model for recovering the pixel labels of the training images. The model connects superpixels from all training images in a data-driven fashion, based on their appearance similarity. For generalizing to new test images we integrate them into MIM using a learned multiple kernel metric, instead of learning conventional classifiers on the recovered pixel labels. We also introduce an “objectness” potential, that helps separating objects (e.g. car, dog, human) from background classes (e.g. grass, sky, road). In experiments on the MSRC 21 dataset and the LabelMe subset of [18], our technique outperforms previous weakly supervised methods and achieves accuracy comparable with fully supervised methods.
New Attestation Based Security Architecture for In-Vehicle Communication (2008)

This paper presents a novel security architecture for in-vehicle communication. The ratio of electronics to vehicle equipment is steadily increasing. And novel vehicles will also have connectibility to public networks to provide many kinds of services. Therefore, they are expected to suffer from a wide variety of threats and the electronic control units (ECUs) embedded in them may execute execute malicious programs because of tampering. The remote attestation scheme with the trusted platform module (TPM) has been attracting a great deal of attention to cope with such issues. However, it is not feasible for vehicle systems because the conventional attestation process cannot adapt to in-vehicle communication and TPM cannot adapt to time-constrained vehicle systems. We propose an attestation based security architecture that is suitable for novel vehicles.
Genetics and alcoholism among at‐risk relatives I: Perceptions of cause, risk, and control (2004)

Genetic factors influence a person's risk for developing alcoholism. In other common disorders with a genetic component, a belief in a genetic cause can lead to less perceived control or fatalism among those at risk that may adversely affect undertaking health-promoting behaviors. This study explores beliefs about the cause of alcoholism and risk perception among individuals with affected relatives. In-depth interviews including both open-ended questions and several quantitative measures were conducted with participants to explore the relationships between causal beliefs and perceptions of personal risk and control. Twenty-seven individuals with at least one first-degree relative affected with alcoholism participated. Transcript analysis of interviews revealed that all participants attribute multiple factors to the cause of alcoholism in their families, often as a combination of biological, genetic, environmental factors, and personal characteristics. Many perceived themselves as being 'at-risk,' and this concern often stemmed from a belief in a genetic or biological cause of alcoholism. However, participants also had a strong sense of personal control, rooted in beliefs about environmental causes or personal characteristics influencing alcoholism risk. A participant's strong belief in a genetic cause was associated with a significantly increased risk perception, but not a fatalistic outlook towards developing alcoholism.
Low IFT Gas-Oil Gravity Drainage in Fractured Carbonate Porous Media (2008)

Abstract This paper addresses a study of gas-oil gravity drainage in fractured carbonate rock subjected to gas injection in low interfacial tension. The purpose of the experiments described in the paper was to investigate gas injection in fractured carbonate reservoirs in both secondary and tertiary cases (after water injection), focusing on gravity drainage using equilibrium gas followed by re-pressurization. Gas injection experiments were performed on 20 cm long and low permeable outcrop chalk core surrounded with a fracture established with a novel experimental set-up in reservoir conditions. The core was saturated with binary mixture live oil consisting of C1 and C7 of a known composition, while the fracture was filled with sealing material to obtain a homogeneous saturation. After core initialization, the sealing material was removed by increasing the temperature to higher than its melting point and displaced by live oil. Gas was then injected into the fracture and gravity drainage experiments were performed in low interfacial tension (&amp;lt; 0.5 mN/m) where the IFT between the phases were measured experimentally by selecting the proper pressure and temperature. Experiments were performed at different pressures and reversibility of the effect of the interfacial tension was checked by re-pressurization process. The oil recovered from the bottom side of the block was measured versus time. Based on the results of this study, the recovery of oil showed a significant increase by re-pressurization in gravity drainage process. It was also clear that low-IFT gravity drainage is capable to recover a significant amount of oil in fractured reservoirs even after water injection.
Route flap damping exacerbates internet routing convergence (2002)

Route flap damping is considered to be a widely deployed mechanism in core routers that limits the widespread propagation of unstable BGP routing information. Originally designed to suppress route changes caused by link flaps, flap damping attempts to distinguish persistently unstable routes from routes that occasionally fail. It is considered to be a major contributor to the stability of the Internet routing system.We show in this paper that, surprisingly, route flap damping can significantly exacerbate the convergence times of relatively stable routes. For example, a route to a prefix that is withdrawn exactly once and re-announced can be suppressed for up to an hour (using the current RIPE recommended damping parameters). We show that such abnormal behavior fundamentally arises from the interaction of flap damping with BGP path exploration during route withdrawal. We study this interaction using a simple analytical model and understand the impact of various BGP parameters on its occurrence using simulations. Finally, we outline a preliminary proposal to modify route flap damping scheme that removes the undesired interaction in all the topologies we studied. .
Study of electroluminescence of InAs(Sb,P) LED heterostructures (2017)

Electroluminescence of InAs(Sb,P) heterostructures grown on InAs substrates was studied in the temperature range T = 4.2−300 K. At low temperatures (T = 4.2−50 K), stimulated emission was observed. This effect was due to optical resonator, which was formed between the lower face of the LED chip with the solid metal contact and the upper face with semiconductor/air interface. The emission became spontaneous at higher temperatures due to the effect of CHHS Auger recombination process, when the energy of a recombining electron-hole pair was transferred to another hole with the latter transitioning to the spin-orbit-splitted band. The results obtained show that structures based on InAs(Sb,P) are a promising material for fabrication of vertical-emitting mid-infrared lasers.
Power System Recovery Coordinated with (Non-)Black-Start Generators (2023)

Power restoration is an urgent task after a black-out, and recovery efficiency is critical when quantifying system resilience. Multiple elements should be considered to restore the power system quickly and safely. This paper proposes a recovery model to solve a direct-current optimal power flow (DCOPF) based on mixed-integer linear programming (MILP). Since most of the generators cannot start independently, the interaction between black-start (BS) and non-black-start (NBS) generators must be modeled appropriately. The energization status of the NBS is coordinated with the recovery status of transmission lines, and both of them are modeled as binary variables. Also, only after an NBS unit receives cranking power through connected transmission lines, will it be allowed to participate in the following system dispatch. The amount of cranking power is estimated as a fixed proportion of the maximum generation capacity. The proposed model is validated on several test systems, as well as a 1393-bus representation system of the Puerto Rican electric power grid. Test results demonstrate how the recovery of NBS units and damaged transmission lines can be optimized, resulting in an efficient and well-coordinated recovery procedure.
A Case of Aortitis Syndrome Associated with Occlusion of All Arch Branches and Atypical Aortic Coarctation. (2000)

症例は61歳, 男性. 異型大動脈縮窄症, 高度左室肥大に伴う急性心不全で今回緊急入院した. 血管造影およびMRIでは, 弓部分枝がすべて閉塞し, 大動脈縮窄前後の肋間動脈からの側副血行路と右内胸動脈, 右胸背動脈の逆行性血流をうける右椎骨動脈により脳血流が供給されていた. 頭部CTでは右中大脳動脈領域の脳梗塞症を認めた. 大動脈炎症候群IV型と診断し, 上行-腹部大動脈バイパスおよび大動脈-右鎖骨下動脈バイパス術を施行した. 上行大動脈の部分遮断による大動脈圧上昇を回避するため, 腹部大動脈および右鎖骨下動脈にあらかじめ吻合したグラフトから送血を行い体外循環補助下に中枢側吻合を行った. 近赤外線酸素モニター (NIRS) を術中脳血流モニターとして用い, 周術期の脳合併症を認めなかった. 弓部分枝全閉塞と異型大動脈縮窄を伴った本症候群例の手術において, NIRSは術中脳循環モニター法として有用であった.
Numerical Simulation of Pulsatile Flow in a Compliant Curved Tube Model of a Coronary Artery (1999)

The endothelial cells (ECs) lining a blood vessel wall are exposed to both the wall shear stress (WSS) of blood flow and the circumferential strain (CS) of pulsing artery wall motion. These two forces and their interaction are believed to play a role in determining remodeling of the vessel wall and development of arterial disease (atherosclerosis). This study focused on the WSS and CS dynamic behavior in a compliant model of a coronary artery taking into account the curvature of the bending artery and physiological radial wall motion. A three-dimensional finite element model with transient flow and moving boundaries was set up to simulate pulsatile flow with physiological pressure and flow wave forms characteristic of the coronary arteries. The characteristic coronary artery curvature and flow conditions applied to the simulation were: aspect ratio (lambda) = 10, diameter variation (DV) = 6 percent, mean Reynolds number (Re) = 150, and unsteadiness parameter (alpha) = 3. The results show that mean WSS is about 50 percent lower on the inside wall than the outside wall while WSS oscillation is stronger on the inside wall. The stress phase angle (SPA) between CS and WSS, which characterizes the dynamics of the mechanical force pattern applied to the endothelial cell layer, shows that CS and WSS are more out of phase in the coronaries than in any other region of the circulation (-220 deg on the outside wall, -250 deg on the inside wall). This suggests that in addition to WSS, SPA may play a role in localization of coronary atherosclerosis.
Flexible transceiver array for ultrahigh field human MR imaging (2012)

A flexible transceiver array, capable of multiple-purpose imaging applications in vivo at ultrahigh magnetic fields was designed, implemented and tested on a 7 T MR scanner. By alternately placing coil elements with primary and secondary harmonics, improved decoupling among coil elements was accomplished without requiring decoupling circuitry between resonant elements, which is commonly required in high-frequency transceiver arrays to achieve sufficient element-isolation during radiofrequency excitation. This flexible array design is capable of maintaining the required decoupling among resonant elements in different array size and geometry and is scalable in coil size and number of resonant elements (i.e., number of channels), yielding improved filling factors for various body parts with different geometry and size. To investigate design feasibility, flexibility, and array performance, a multichannel, 16-element transceiver array was designed and constructed, and in vivo images of the human head, knee, and hand were acquired using a whole-body 7 T MR system. Seven Tesla parallel imaging with generalized autocalibrating partially parallel acquisitions (GRAPPA) performed using this flexible transceiver array was also presented.
Aromatic plants of tropical central Africa. Part XIX. Volatile components from leaves of two lamiaceae from Cameroon: leucas deflexa hook and Solenostemon monostachyus (P.Beauv.) Briq. (1994)

Abstract The chemical composition of the essential oils isolated by hydrodistillation from leaves of Leucas deflexa Hook and of Solenostemon monostachyus (P.Beauv.) Briq. grown in Cameroon, has been investigated by GC and GC‐MS. The leaf essential oil of L. deflexa was characterized by a high amount of sesquiterpene hydrocarbons (80.3%), germacrene‐D (27.8%), β‐caryophyllene (24.1%) and α‐humulene (9.9%) being the major components. The leaf essential oil of S. monostachyus was more complex; β‐pinene (13.0%), oct‐1‐en‐3‐ol (12.6%), β‐caryophyllene (6.9%), octan‐3‐ol (6.8%) and ( E,E )‐α‐farnesene (6.2%) were the most abundant constituents.
Polyesters from Dilactones (2009)

This chapter contains sections titled: Introduction General Concepts and ROP Promoted by Metallic Catalysts/Initiators Recent Advances in ROP Macromolecular Engineering Applications Summary and Prospects Acknowledgments References
Theoretical background for aerodynamic shape optimization (2018)

A Hessian Matrix / Operator a Integrand of Integral Hessian Operator C Constant E Error of Discretization F Integrand of Cost Function G Gradient of Cost Function Ḡ Implicitly-Smoothed Gradient g Acceleration due to Gravity ≃ 32.2 ft sec2 GRMS Root-Mean-Square of Gradient Vector H Estimate of Inverse Hessian Matrix I Objective or Cost Function IR Discrete I based on Rectangle Rule ITERS Iterations needed for 10 Reduction i Matrix Row Index j Spatial Index; Matrix Column Index k Generic Index K Upper Limit of Generic Index k N Number of Design Variables n Iteration Index NMESH Number of Multigrid Levels NX Number of Mesh Intervals P Multigrid Forcing Function P Error Vector of Rank-One Scheme Q Multigrid Transfer Operator STEP Input Parameter Similar to CFL Number Surplus I R − I D R s Arch Length T Total Time; Multigrid Transfer Operator t Parametric Variable; Time v Velocity X Design Variable x Independent Spatial Variable X Design Space Vector [X,Y,Z] Y Design Variable y Design Variable Y ERR L2 Norm of y − yexact vector Z Design Variable α Tridiagonal Coefficient of Implicit Scheme β Coefficient of Parabolic Term γ Recombination Coefficients ǫ Implicit Smoothing Parameter λ Time-Step Parameter ξ Free Variable π 3.141592654... ∞ Infinity
Deep Learning-Based Computer Vision for Surveillance in ITS: Evaluation of State-of-the-Art Methods (2021)

Intelligent transportation system (ITS) collects numerous data for analysis of the transportation system. The data can be used for providing services for travellers and traffic controllers in the ITS and optimizing it, for the purpose of making the transportation more efficient and safer. Due to the wide and flexible employment of video cameras in visual surveillance system (VSS), mature edge-cloud resource scheduling for data transmission and analysis, and the fast development of deep learning, computer vision (CV) methods have been employed in the visual-based ITS services successfully. In this paper, we discuss the edge-cloud surveillance resource scheduling for the CV methods and review the deep learning-based CV methods in the VSS, including detection, classification, and tracking methods, for better understanding of the relationship between the CV-based ITS services and these methods. We experimentally compare several state-of-the-art deep learning-based methods, which have been successfully applied in the CV fields under the ITS scenario, on their performance, inference speed, computational quantity, and model size. According to the comparisons, we propose four main challenges of the deep learning-based CV methods applied in the services, as a discussion of the future research directions. Code are available at <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/PRIS-CV/DL-CV-ITS</uri> .
Functional interactions between the human papillomavirus type 16 E7 oncoprotein and the tumor suppressor p53 (2002)

[no abstract]
Effect of charged and excited states on the decomposition of 1,1-diamino-2,2-dinitroethylene molecules (2007)

The authors have calculated the electronic structure of individual 1,1-diamino-2,2-dinitroethylene molecules (FOX-7) in the gas phase by means of density functional theory with the hybrid B3LYP functional and 6-31+G(d,p) basis set and considered their dissociation pathways. Positively and negatively charged states as well as the lowest excited states of the molecule were simulated. They found that charging and excitation can not only reduce the activation barriers for decomposition reactions but also change the dominating chemistry from endo- to exothermic type. In particular, they found that there are two competing primary initiation mechanisms of FOX-7 decomposition: C-NO2 bond fission and C-NO2 to CONO isomerization. Electronic excitation or charging of FOX-7 disfavors CONO formation and, thus, terminates this channel of decomposition. However, if CONO is formed from the neutral FOX-7 molecule, charge trapping and/or excitation results in spontaneous splitting of an NO group accompanied by the energy release. Intramolecular hydrogen transfer is found to be a rare event in FOX-7 unless free electrons are available in the vicinity of the molecule, in which case HONO formation is a feasible exothermic reaction with a relatively low energy barrier. The effect of charged and excited states on other possible reactions is also studied. Implications of the obtained results to FOX-7 decomposition in condensed state are discussed.
Supplementary Figure 1 from Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis (2023)

&lt;p&gt;Characterization of exosomal AnxA2&lt;/p&gt;
Male Infertility (2023)

No AccessJournal of UrologyUrological Survey1 Jun 2023Male Infertility Craig NiederbergerMD Craig NiederbergerCraig Niederberger More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003417AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue 6June 2023Page: 1216-1218 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Craig Niederberger More articles by this author Expand All Advertisement PDF downloadLoading ...
Formation of hydroxyapatite–polyphosphazene polymer composites at physiologic temperature (2006)

Aspects of the formation of bone analog composites at 37 degrees C are described. The composites are composed of hydroxyapatite (HAp) and the calcium salt of a biocompatible polymer and are capable of forming under in vivo conditions. Composite formation involves the formation of monolithic HAp from particulate calcium phosphate precursors while Ca ions liberated to the aqueous medium in which this reaction is occurring form crosslinks with the acidic polymer. The reactants are poly[bis(carboxylatophenoxy)phosphazene] (acid-PCPP), tetracalcium phosphate [Ca4(PO4)2O, TetCP], and anhydrous dicalcium phosphate (CaHPO4, DCPA). The effects of the proportion of polymer (5, 10, or 15 wt %) on the kinetics of HAp formation were studied. Compositional evolution of the solid calcium phosphates present was followed by X-ray diffraction and infrared spectroscopy analyses. HAp formation through a dissolution-precipitation process provided a mildly alkaline medium suitable for deprotonation of the acid-PCPP and for the formation of the calcium crosslinks, as monitored by infrared spectroscopy. Concurrence of crosslinking of the polymer and HAp formation was established, indicating true composite formation can be realized at physiologic temperature.