gebhart/patrepeval huggingface dataset:
Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart – a longitudinal MR study (2014)

The chronic administration of the β-adrenoreceptor agonist isoproterenol (IsoP) is used in animals to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines. Time-dependent changes in myocardial blood flow (MBF), morphological and functional parameters were assessed in rats in vivo using multimodal cardiac MRI. Energy metabolism, oxidative stress and the nitric oxide (NO) pathway were evaluated in isolated perfused rat hearts following 7 days of treatment. Male Wistar rats were infused for 7 days with IsoP or vehicle using osmotic pumps. Cine-MRI and arterial spin labeling were used to determine left ventricular morphology, function and MBF at days 1, 2 and 7 after pump implantation. Isolated hearts were then perfused, and high-energy phosphate compounds and intracellular pH were followed using ³¹P MRS with simultaneous measurement of contractile function. Total creatine and malondialdehyde (MDA) contents were measured by high-performance liquid chromatography. The NO pathway was evaluated by NO synthase isoform expression and total nitrate concentration (NO(x)). In IsoP-treated rats, left ventricular mass was increased at day 1 and maintained. Wall thickness was increased with a peak at day 2 and a tendency to return to baseline values at day 7. MBF was markedly increased at day 1 and returned to normal values between days 1 and 2. The rate-pressure product and phosphocreatine/adenosine triphosphate ratio in perfused hearts were reduced. MDA, endothelial NO synthase expression and NO(x) were increased. Sustained high cardiac function and normal MBF after 24 h of IsoP infusion indicate imbalance between functional demand and blood flow, leading to morphological changes. After 1 week, cardiac hypertrophy and decreased function were associated with impaired phosphocreatine, increased oxidative stress and up-regulation of the NO pathway. These results provide supplemental information on the evolution of the different contributing factors leading to morphological and functional changes in this model of cardiac hypertrophy and failure.
Neo-tribes (2006)

Online communities deserve better than their current treatment---where they are largely relegated to the fringes of health care.
Evaluation of Antinociceptive, Anti-inflammatory and Antipyretic Effects of Strobilanthes cusia Leaf Extract in Male Mice and Rats (2003)

The leaf of Strobilanthes cusia (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used for influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia and mumps. It is also used to treat sore throat, aphthae and inflammatory diseases with redness of skin, etc. In this study, we evaluated the antinociceptive, anti-inflammatory and antipyretic effects of methanol extract of Strobilanthes cusia leaf. The results showed that the extract significantly inhibited the writhing responses of mice and decreased the licking time on both the early and late phases of the formalin test in a dose-dependent manner. It also reduced the paw edema induced by carrageenan in rats. In addition, it potently attenuated pyrexia induced by lipopolysaccharide.
Platelets: Indicator of inflammation in COPD (2009)

COPD is a disease presenting with pulmonary inflammation as well as a systemic one. The present study was conducted to see if platelet count may be accepted as an indicator of systemic inflammation other than erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). 964 smoker patients without any concomitant disease were divided into groups as COPD and non-COPD according to spirometric values. Physical examination, posteroanterior chest x-rays and blood samples were determined. Patients with COPD had higher  ESR, CRP levels and platelet count than the group without COPD. According to spirometric parameters, as the severity of the disease increased, platelet counts also revealed a statistically significant increase. We conclude that the increase in the number of platelets may be an indicator of severity of  the disease and sytemic inflammation in patients with COPD.

	Key words: Platelet, inflammation, COPD.
Real-Space Observation of Current-Driven Domain Wall Motion in Submicron Magnetic Wires (2004)

We report direct observation of current-driven magnetic domain wall (DW) displacement by using a well-defined single DW in a microfabricated magnetic wire with submicron width. Magnetic force microscopy visualizes that a single DW introduced in a wire is displaced back and forth by positive and negative pulsed current, respectively. The direct observation gives quantitative information on the DW displacement as a function of the intensity and the duration of the pulsed current. The result is discussed in terms of the spin-transfer mechanism.
Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis (2013)

The subtle differences observed in the domains of expression between different glycosaminoglycan moieties suggest differences in their functional roles during establishment of the primitive analogues of the skeleton.
Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes. (1985)

In Xenopus laevis oocytes, adenosine and other purinergic agonists induce a K+-conductance increase that is fully mimicked by intracellular application of cAMP. Acetylcholine suppresses the K+-conductance increase caused by adenosine, by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, or by intracellular injection of cAMP. This effect of acetylcholine is not mimicked by intracellular injection of Ca2+ or of the Ca-mobilizing agent inositol 1,4,5-trisphosphate. However, adenosine and cAMP responses are inhibited by 4 beta-phorbol 12,13-dibutyrate and 4 beta-phorbol 12-myristate 13-acetate. These results suggest that, in Xenopus oocytes, the muscarinic inhibition of purinergic and cAMP responses is mediated through the activation of the phospholipid-dependent, Ca-activated protein kinase (protein kinase C).
The effects of restricted workspace on lumbar spine loading (2001)

Coal miners often handle heavy electrical power cables, weighing up to 10 kg per meter. These cables are manually lifted and attached to the mine roof to prevent damage from mobile underground equipment. Data suggest that workers who commonly perform cable-handling tasks experience a high rate of lost-time back injuries. In this study, six male underground miners performed a total of 12 cable-hanging tasks in standing, stooping, and kneeling postures, during which kinematic and ground reaction force data were collected. Reductions in vertical workspace were found to result in a linear increase in the peak moment experienced by the lumbar spine p &lt; 0.05). In restricted postures, peak moments were not significantly different in stooping vs. kneeling postures (p &gt; 0.05). Average lumbopelvic flexion during the tasks was highest in stooping conditions, followed by standing and kneeling exertions (p &lt; 0.05). Implications of this data with respect to design of cable handling tasks are presented and discussed.
Treatment of intra-articular hip malignancy with extra-articular resection, preservation of the acetabular columns, and total hip arthroplasty (2018)

Intra-articular malignant lesions of the hip present significant challenges. Resection often requires large resection of the acetabular bone and pelvic columns. Concurrent reconstruction options after intra-articular hip tumors are challenging and may necessitate the use of techniques and implants with uncertain long-term survivorship. We present a case of an intra-articular hip malignancy with extra-articular resection and preservation of the acetabular columns with reconstruction using a cementless acetabular shell fixed with screws.
Real-time multitarget tracking for sensor-based sorting (2017)

Utilizing parallel algorithms is an established way of increasing performance in systems that are bound to real-time restrictions. Sensor-based sorting is a machine vision application for which firm real-time requirements need to be respected in order to reliably remove potentially harmful entities from a material feed. Recently, employing a predictive tracking approach using multitarget tracking in order to decrease the error in the physical separation in optical sorting has been proposed. For implementations that use hard associations between measurements and tracks, a linear assignment problem has to be solved for each frame recorded by a camera. The auction algorithm can be utilized for this purpose, which also has the advantage of being well suited for parallel architectures. In this paper, an improved implementation of this algorithm for a graphics processing unit (GPU) is presented. The resulting algorithm is implemented in both an OpenCL and a CUDA based environment. By using an optimized data structure, the presented algorithm outperforms recently proposed implementations in terms of speed while retaining the quality of output of the algorithm. Furthermore, memory requirements are significantly decreased, which is important for embedded systems. Experimental results are provided for two different GPUs and six datasets. It is shown that the proposed approach is of particular interest for applications dealing with comparatively large problem sizes.
Molecular Cloning and Expression of cDNA Encoding Chicken UDP-N-acetyl-d-glucosamine (GlcNAc): GlcNAcβ1–6(GlcNAcβ1–2)- Manα1-R[GlcNAc to Man]β1,4N-acetylglucosaminyltransferase VI (2000)

A cDNA that encodes UDP-N-acetyl-d-glucosamine (GlcNAc):GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R[GlcNA c to Man]beta1, 4N-acetylglucosaminyltransferase VI (GnT VI), which is responsible for the formation of pentaantennary asparagine-linked oligosaccharides (N-glycans), has been cloned from a hen oviduct cDNA library based on the partial amino acid sequences of the purified enzyme. The isolated cDNA clone contained an open reading frame encoding 464 amino acids, including all of the peptides that were sequenced. The deduced amino acid sequence predicts a type II transmembrane topology and contains two potential N-glycosylation sites. The primary structure was found to be significantly similar to human GnT IV-homologue, the gene for which was cloned from the deleted region in pancreatic cancer, and to human and bovine GnT IVs. Chicken GnT VI-transfected COS-1 cells showed a high GnT VI activity (26.8 pmol/h/mg protein), whereas nontransfected, mock-transfected, or human GnT IV-homologue-transfected COS-1 cells had no activity. Northern blot analysis using poly(A)(+) RNA from hen oviduct indicated that the size of GnT VI mRNA is 2.1 kilobases. Reverse transcription-polymerase chain reaction analysis showed that GnT VI mRNA was relatively highly expressed in oviduct, spleen, lung, and colon.
Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome (2021)

Flavonoids are a subclass of polyphenols which are attractive, due to possessing various physiological activities, including a radioprotective effect. Tumor suppressor p53 is a primary regulator in the radiation response and is involved in the pathogenesis of radiation injuries. In this study, we revealed that isorhamnetin inhibited radiation cell death, and investigated its action mechanism focusing on DNA damage response. Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells. The radioprotective effect of isorhamnetin was not observed in the presence of ATM inhibitor, indicating that its protective effect was dependent on ATM. Furthermore, isorhamnetin-treated mice survived gastrointestinal death caused by a lethal dose of abdominal irradiation. These findings suggested that isorhamnetin enhances the ATM-dependent DNA repair process, which is presumably associated with the suppressive effect against GI syndrome.
Ion Beam Analysis for Hall Scattering Factor Measurements in Antimony Implanted Bulk and Strained Silicon (2014)

Rutherford back-scattering (RBS) and Medium Energy Ion Scattering (MEIS) have been used to determine the lattice site occupancy of antimony (Sb) implanted into silicon (Si) and strained silicon (sSi) for ion energies of 2keV to 40keV. After annealing in the range 600-1100°C for various times, Hall effect measurements were used to provide a measure of the percentage electrical activity. A comparison of the lattice site occupancy with the percentage electrical activity was used to confirm whether the assumption that the Hall scattering factor is equal to unity is valid. Our results demonstrate that for 40keV implants the electrical activation is about 90%. In the case of 2keV implants the electrical activation is lower and in the range 10-80%, depending on the ion fluence and annealing conditions. This reduction in activation for lower energy implants is a result of inactive Sb close to the semiconductor/native-oxide interface, or above concentrations of 4.5x10 20 cm' 3 . Tensile strain facilitates the lattice site occupancy and electrical activation of Sb in Si by raising the doping ceiling. For both 40keV and 2keV implants, we have carried out a comparison of RBS/MEIS and Hall effect data to show that for Sb implants into both bulk Si and strained Si the Hall scattering factor is equal to unity within experimental error.
Combustion Analysis of Dual Fuel Operation in Single Cylinder Research Engine Fuelled with Methane and Diesel (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In the present activity, dual fuel operation was investigated in a single cylinder research engine. Methane was injected in the intake manifold while the diesel was delivered via the standard injector directly into the engine. The aim is to study the effect of increasing methane concentration at constant injected diesel amount on both pollutant emissions and combustion evolution in an optically accessible engine. Emissions are in line with those previously published by other authors, it is noted no PM and constant NOx emissions. Moreover, a decrease of the brake specific CO emissions and an increase of the brake specific THC for the operating condition with the highest premixed ratio was detected. THC was mainly constituted by methane unburned hydrocarbons. Combustion resulted more or less stable. Moreover, via both UV-VIS spectroscopy and digital imaging, the spatial distribution of several species involved in the combustion process was analyzed. In particular, OH radical was recognized via chemiluminescence analysis and its integral intensity from UV digital imaging was compared with the ROHR of the several operating conditions investigated. Ignition delay is not affected by the premixed charge of methane. Moreover, the premixed combustion shows stronger OH radical emission, more than an order of magnitude, increasing the methane quantity in the burning charge.&lt;/div&gt;&lt;/div&gt;
Choice of Foods and Ingredients for Moderately Malnourished Children 6 Months to 5 Years of Age (2009)

There is consensus on how to treat severe malnutrition, but there is no agreement on the most cost-effective way to treat infants and young children with moderate malnutrition who consume cereal-dominated diets. The aim of this review is to give an overview of the nutritional qualities of relevant foods and ingredients in relation to the nutritional needs of children with moderate malnutrition and to identify research needs. The following general aspects are covered: energy density, macronutrient content and quality, minerals and vitamins, bioactive substances, antinutritional factors, and food processing. The nutritional values of the main food groups--cereals, legumes, pulses, roots, vegetables, fruits, and animal foods--are discussed. The special beneficial qualities of animal-source foods, which contain high levels of minerals important for growth, high-quality protein, and no antinutrients or fibers, are emphasized. In cereal-dominated diets, the plant foods should be processed to reduce the contents of antinutrients and fibers. Provision of a high fat content to increase energy density is emphasized; however, the content of micronutrients should also be increased to maintain nutrient density. The source of fat should be selected to supply optimal amounts of polyunsaturated fatty acids (PUFAs), especially n-3 fatty acids. Among multiple research needs, the following are highlighted: to identify the minimum quantity of animal foods needed to support acceptable child growth and development, to examine the nutritional gains of reducing contents of antinutrients and fibers in cereal- and legume-based diets, and to examine the role of fat quality, especially PUFA content and ratios, in children with moderate malnutrition.
Estimation of APU Failure Parameters Employing Linear Regression and Neural Networks (2013)

&#x0D; &#x0D; &#x0D; This study is concerned with the building of an appropriate model to estimate failure parameters of an Auxiliary Power Unit (APU). Linear and nonlinear models were used in order to evaluate which model is more suitable for this application. Data for model building and testing were obtained by simulating a nonlinear dynamic model of APU in Matlab/Simulink for various operating conditions to which it may be subjected to and with different levels of failure parameter degradation. Linear models were obtained by least-squares regression, whereas nonlinear models were obtained by training neural networks. The results obtained with these two models were compared. As a result, the neural network models were found to provide a better estimate of the APU failure parameters.&#x0D; &#x0D; &#x0D;
Observation of room temperature saturated ferroelectric polarization in Dy substituted BiFeO3 ceramics (2012)

High quality Bi1−xDyxFeO3 (0 ≤ x ≤ 0.15) ceramics have been fabricated by sintering Dy-doped BiFeO3 (BFO) precursor powders at a low temperature of 780 °C. The magnetic properties of BFO were improved by the introduction of Dy on the Bi-site. More importantly, well saturated ferroelectric hysteresis loops and polarization switching currents have been observed at room temperature. A large remnant polarization (2Pr) value of 62 μC/cm2 is achieved, which is the highest value reported so far for rare-earth-doped BFO ceramics. Moreover, mechanisms for improved multiferroic properties depending on chemical doping-caused structure evolutions have also been discussed.
The effect of capsaicin on C-fiber reflex and heat evoked discharge in the acute spinal cat. (1983)

The effects of capsaicin were studied electrophysiologically on C-fiber reflex and heat-evoked discharge in adult spinal cats. The results can be summarized as follows: 1) 125 micrograms/Kg of capsaicin, administered intravenously, induced an increase in spontaneous discharge in the L7 ventral root; 2) 250 micrograms/Kg of capsaicin, administered intravenously, induced an increase in the C-fiber reflex response; 3) 125 micrograms/Kg of capsaicin, administered intravenously, induced an increase in the heat-evoked discharge; but 4) 25 micrograms/Kg of capsaicin, administered through the femoral artery, did not show significant alteration of the heat-evoked discharge. These findings suggest that capsaicin which produced a release of substance-P from primary afferent nerves may principally act on C-fiber and A delta-fiber. Capsaicin was much more effective on the heat-evoked discharge than on the C-fiber reflex when administered intravenously.
Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. (1975)

A direct approach has been developed for quantitative identification of the calcium-binding amino acid, gamma-carboxyglutamate, in proteins. This should be advantageous for the study of numerous systems where specific roles for the binding of calcium or other divalent cations are suspected. Investigation of mineralized tissue, where calcium-binding proteins are implicated in the mineralization process, revealed that gamma-carboxyglutamate was present in proteins solubilized from chicken bone with neutral aqueous ethylenediamine tetraacetic acid. This was established by direct isolation of the amino acid from alkaline hydrolysates and its quantitative conversion to glutamic acid by decarboxylation in 0.05 M HCl at 100 degrees. The kinetics of decarboxylation and chromatographic behavior are identical to those of gamma-carboxyglutamate from human prothrombin. After resolution of the soluble bone proteins by phosphate gradient elution from hydroxyapatite, gamma-carboxyglutamate was found to be concentrated primarily in one BaSO4-adsorbable anionic protein species; bone collagen was devoid of the amino acid. In view of the recently discovered requirement of vitamin K for generation of calcium binding sites (gamma-carboxyglutamate) by gamma-carboxylation of specific glutamic acid residues in prothrombin, our findings may implicate vitamin K metabolism in normal bone development and suggest a role for the gamma-carboxyglutamate-rich protein in regulation of calcium salt deposition in mineralized tissues.
Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors (1996)

This study investigates the effect of the NO synthase inhibitors,NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), on the neurological deficit 24 h after a moderate closed head injury in mice. Low doses of L-NAME or 7-NI given soon after the injury significantly reduced the neurological deficit compared to the vehicle-treated group. L-Arginine (300 mg/kg) did not alter the neurological deficit, but reversed the protective effects of both L-NAME and 7-NI when given at the same time. Both L-NAME and 7-NI had dose-related effects. The neuroprotective effects of L-NAME and 7-NI occurred when the drugs were given 5, 30, or 60 min after brain injury, but not when treatment was begun 2 h after brain injury, suggesting a short therapeutic window for both drugs. These results suggest that NO synthesis by neuronal NO synthase plays an important role in the early neurotoxic cascade leading to neurological deficit following traumatic brain injury.
Teknologiaren zeregina ikaslearengan ardaztutako ikaskuntzan eta ikaslearengan ardaztutako irakaskuntza/ikaskuntzararen garapena (2000)

Donostian 1999ko uztailean emandako hiru hitzaldien ildo nagusiak laburbildu nahi izan dira artikulu honetan.

Aurreneko zatian, ikaslearengan ardaztutako ikaskuntzaren eta ikaskuntza-autonomiaren arlo teoriko oinarrizkoak azaltzen dira. Haurraren garapenaren oinarrizko prozesuak giza ikaskuntzaren paradigmatzat erabiliz, esan daiteke ikaskuntza-autonomia gizarte-eraginaren bidez garatzen dela; eta ez, noski, ikaslea bakarrik eta bere kasa utzita.

Bigarren zatian, teknologiak ikaskuntza-autonomiari egin dakiokeen ekarpenaz ari da egilea. Lehenik, hizkuntz ikaskuntzan erabiltzen den teknologiak azken berrogei urteetan izan duen garapenari ematen diot gainbegiratua; ondoren, berrikuntza teknologiko jarraituak irakaslerik gabeko hizkuntz ikaskuntzaren ikuspegiari nola eragin dion azaltzen du labur-labur, eta gero, Dublineko Trinity College-ko CLCS zentroan (Hizkuntz eta Komunikazio Ikerketetarako Zentroan) ikaskuntza-autonomiak nolako garapena izan duen ikusiko dugu.

Azkenik, hizkuntza posta elektroniko bidez eta MOO bidez (testuan oinarritutako errealitate birtuala) bikoteka ikasteaz arituko naiz, CLCS zentroan azken aldian ikerketa- eta garapen-ahalegin handia egin baitute horretan. Hemen ere gizarte-eraginaren garrantzia nabarmenduko dugu, nola hizkuntz ikaskuntzan, hala ikaskuntza-autonomiaren garapenean.