gebhart/patrepeval huggingface dataset:
Growth factor modulation of fibroblasts in simulated wound healing (1996)

Growth factors are potent bioactive molecules responsible for the co-ordination of many cells functions and interactions. Of these agents PDGF and IGF have shown particular promise as agents which may be used to stimulate periodontal regeneration. In order to further understand the mechanisms by which growth factors may work, a simple model of in vitro wound healing has been utilized to assess the effects of PDGF on human periodontal ligament fibroblasts and its potential to stimulate wound healing. Human periodontal ligament fibroblasts were plated into 24-well plates and upon reaching confluence were wounded by creating uniform discoid lesions stripped of cells. The influence of various concentrations of PDGF on cell proliferation, cell migration and extracellular matrix synthesis was monitored. The results of this study indicated that in the presence of 10 ng/ml PDGF on 0.2% fetal calf serum, both cell proliferation and cell migration were significantly stimulated. In the wounded cultures, PDGF appeared to cause a moderate stimulation of proteoglycan synthesis compared to unwounded cultures. In conclusion, the model system tested appears to be useful for studying fundamental cellular and biochemical events associated with wound healing. The effects of PDGF in this system confirm that it is capable of modulating fibroblasts in a manner compatible with the events associated with wound repair.
Donor-specific tolerance induced by simultaneous allogeneic islet transplantation with CD4+CD25+T-cells into hepatic parenchyma in mice (2004)

The simultaneous ITxHP with CD4+CD25+ T-cells administration prolonged islet graft survivals and induced donor-specific hyporesponsiveness.
Rapid Colorimetric Detection of Wound Infection with a Fluidic Paper Device (2022)

Current procedures for the assessment of chronic wound infection are time-consuming and require complex instruments and trained personnel. The incidence of chronic wounds worldwide, and the associated economic burden, urge for simple and cheap point-of-care testing (PoCT) devices for fast on-site diagnosis to enable appropriate early treatment. The enzyme myeloperoxidase (MPO), whose activity in infected wounds is about ten times higher than in non-infected wounds, appears to be a suitable biomarker for wound infection diagnosis. Herein, we develop a single-component foldable paper-based device for the detection of MPO in wound fluids. The analyte detection is achieved in two steps: (i) selective immunocapture of MPO, and (ii) reaction of a specific dye with the captured MPO, yielding a purple color with increasing intensity as a function of the MPO activity in infected wounds in the range of 20-85 U/mL. Ex vivo experiments with wound fluids validated the analytic efficiency of the paper-based device, and the results strongly correlate with a spectrophotometric assay.
Person Authentication Using Brainwaves (EEG) and Maximum A Posteriori Model Adaptation (2007)

In this paper, we investigate the use of brain activity for person authentication. It has been shown in previous studies that the brain-wave pattern of every individual is unique and that the electroencephalogram (EEG) can be used for biometric identification. EEG-based biometry is an emerging research topic and we believe that it may open new research directions and applications in the future. However, very little work has been done in this area and was focusing mainly on person identification but not on person authentication. Person authentication aims to accept or to reject a person claiming an identity, i.e., comparing a biometric data to one template, while the goal of person identification is to match the biometric data against all the records in a database. We propose the use of a statistical framework based on Gaussian Mixture Models and Maximum A Posteriori model adaptation, successfully applied to speaker and face authentication, which can deal with only one training session. We perform intensive experimental simulations using several strict train/test protocols to show the potential of our method. We also show that there are some mental tasks that are more appropriate for person authentication than others.
Acid‐Catalyzed Cyclization of Terpenes Under Homogeneous and Heterogeneous Conditions as Probed Through Stereoisotopic Studies: A Concerted Process with Competing Preorganized Chair and Boat Transition States (2009)

Based on stereoisotopic studies and beta-secondary isotope effects, we propose that the acid-catalyzed cyclization of geranyl acetate proceeds through a concerted mechanism. Under heterogeneous conditions (zeolite Y confinement), a preorganized chairlike transition state predominates, whereas under homogeneous conditions the boat- and chairlike transition states are almost isoenergetic. For the case of farnesyl acetate, we propose that under homogeneous conditions a concerted dicyclization occurs with a preorganized boat-chair transition state competing with the chair-chair transition state. Under zeolite confinement conditions, the chair-chairlike dicyclization transition state is highly favorable. The preference of chairlike transition states within the cavities of zeolite Y is attributed to a transition state shape selectivity effect.
IC‐P‐084: CONNECTOME‐WIDE ANALYSIS OF DIFFERENCES BETWEEN NORMAL AGING, MILD COGNITIVE IMPAIRMENT, AND DEMENTIA OF THE ALZHEIMER'S TYPE USING RESTING‐STATE FMRI CONNECTIVITY (2014)

Few resting-state fMRI studies of Alzheimer's disease have investigated changes in connectivity outside of the default-mode network. In this work we aimed to systematically mine the full-brain connectome to identify functional brain networks and associated connections that can discriminate between cognitively normal elderly (CNE) subjects, patients with mild cognitive impairment (MCI), and patients with a dementia of the Alzheimer's type (DAT). We pooled resting-state data from the ADNI2 study and other studies based in Montreal, Canada, including a total of 80 CNE participants, 92 patients with MCI, and 38 patients with DAT. All analyses were implemented with the NIAK software. A bootstrap analysis of stable clusters identified resting-state networks in a data-driven way, and multiple number of networks (called scales) were tested, from 2 to 200. For each subject and scale, a connectome of temporal correlations between the average time series of all networks was derived. A general linear model analysis tested for pairwise group differences independently for each scale (false-discovery rate q<0.1). The significance of the number of discoveries was tested against the global null hypothesis of no group differences across all scales (permutation test with familywise error p<0.05). Scale 40 yielded significant discoveries across all 3 between-group comparisons (Fig 1A), although the MCI-AD contrast was only a trend (p<0.1). As expected, some of the largest effects were detected in default-mode and mesolimbic network regions. However, important group differences were also observed at the subcortical level (thalamus and cerebellar crus II, see Fig 1B). Disease progression was first associated with decreased connectivity between and/or within the prefrontal and temporal lobes (MCI-ECN and DAT-ECN), then with a widespread increase in connectivity between the thalamus and cerebellar crus II with various cortical areas, including the precuneus (DAT-ECN and DAT-MCI) (Fig 1C). We describe changes in the functional organization of mesolimbic structures in MCI, which progress to involve default-mode and subcortical networks in DAT. A. Scale 40 was chosen for further characterization because it showed an appreciable amount of discoveries (around 5% of the connections were significantly different between groups) in all 3 contrasts (MCI-ECN, DAT-ECN and DAT-MCI). B. Discovery percentage maps show, for each contrast separately, the brain networks with the largest effects (above 20% of significant difference in their associated connections for some networks). Across contrasts, 9 networks were identified as showing the largest effects, in the mesolimbic and default-mode networks as well as in the thalamus and cerebellum crus II. C. Effect maps reveal, for each contrast and 4 selected networks, the nature of the change in functional connectivity (t-test maps of significant differences after FDR correction q<0.1).
Radiophysical and Geomagnetic Effects of Rocket Burn and Launch in the Near-the-Earth Environment (2014)

Radiophysical and Geomagnetic Effects of Rocket Burn and Launch in the Near-the-Earth Environment describes experimental and theoretical studies on the effects of rocket burns and launchings on the near-the-Earth environment and geomagnetic fields. It illuminates the main geophysical and radiophysical effects on the ionosphere and magnetosphere sur
Expert panel of the Chinese Society of Cardiology recommendations on beta-blocker therapy in patients undergoing non-cardiac surgery (2015)

The initiation of beta-blockers in the perioperative period of non-cardiac surgery remains controversial. After reviewing all the evidence, the expert panel of the Chinese Society of Cardiology (CSC) believes that there lacks high-quality randomized trial and the use of perioperative beta-blocker can only be considered on a case-by-case basis. Five practical recommendations are presented.
Prevalence of Chlamydial and Gonococcal Infections Among Young Adults (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Model for Worksite Cancer Prevention: Integration of Health Protection and Health Promotion in the WellWorks Project (1995)

Lifestyle changes such as smoking cessation or dietary changes may be more effectively promoted among blue collar audiences when programs also encourage management actions to reduce occupational exposures. Public health professionals trained in health promotion and health protection must work together to effectively address the health concerns of this population.
Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions (2006)

Our induction of tolerance protocol allows some patients who have experienced severe or repetitive infusion reactions to infliximab to be safely retreated with the drug in a hospitalized setting, with a clinical response achieved in a majority of these patients.
On vision in birds: coordination of head-bobbing and gait stabilises vertical head position in quail (2014)

The results are consistent with expectations based on the vertical trunk fluctuations observed in biomechanical models of vaulting and bouncing locomotion. The timing of the head-bobbing behaviour naturally favoured by quail benefits vision during vaulting and bouncing gaits and potentially helps reducing the mechanical cost associated with head bobbing when using a bouncing gait.
Digital Microfluidic Dynamic Culture of Mammalian Embryos on an Electrowetting on Dielectric (EWOD) Chip (2015)

Current human fertilization in vitro (IVF) bypasses the female oviduct and manually inseminates, fertilizes and cultivates embryos in a static microdrop containing appropriate chemical compounds. A microfluidic microchannel system for IVF is considered to provide an improved in-vivo-mimicking environment to enhance the development in a culture system for an embryo before implantation. We demonstrate a novel digitalized microfluidic device powered with electrowetting on a dielectric (EWOD) to culture an embryo in vitro in a single droplet in a microfluidic environment to mimic the environment in vivo for development of the embryo and to culture the embryos with good development and live births. Our results show that the dynamic culture powered with EWOD can manipulate a single droplet containing one mouse embryo and culture to the blastocyst stage. The rate of embryo cleavage to a hatching blastocyst with a dynamic culture is significantly greater than that with a traditional static culture (p<0.05). The EWOD chip enhances the culture of mouse embryos in a dynamic environment. To test the reproductive outcome of the embryos collected from an EWOD chip as a culture system, we transferred embryos to pseudo-pregnant female mice and produced live births. These results demonstrate that an EWOD-based microfluidic device is capable of culturing mammalian embryos in a microfluidic biological manner, presaging future clinical application.
Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients (2009)

OU associated with mTOR inhibitor therapy differed from CM. Lesions more closely resembled those of aphthous stomatitis. The lack of other gastrointestinal involvement but the presence of a higher incidence of concomitant cutaneous AEs provided additional evidence to suggest a distinction between mIAS and CM. Treatment strategies for aphthous stomatitis may be a rational approach for the prevention and control of mIAS.
Métodos para la resolución del problema no lineal de equilibrio estático en sistemas multicuerpo (1998)

En este trabajo se aborda la resolución del problema no lineal de posición de equilibrio\n\t\t\t\t estático y de otros problemas de posición en sistemas mecánicos multicuerpo complejos, que\n\t\t\t\t incluyen elementos rígidos y elásticos. En el estudio se utiliza una función de error sencilla, que se basa en la función potencial e incluye en el análisis a los elementos rígidos por medio de restricciones 110 lineales. Se presenta la aplicación de los Multiplicadores de Lagrange, Funciones de Penalización, Rigideces Ponderadas y de diferentes versiones del método de los\n\t\t\t\t Multiplicadores Aumentados o método Primal-Dual.
New heuristic and interactive approaches to 2D rectangular strip packing (2005)

In this paper, we consider the two-dimensional rectangular strip packing problem. A standard simple heuristic, Bottom-Left-Decreasing (BLD), has been shown to perform quite well in practice. We introduce and demonstrate the effectiveness of BLD*, a stochastic search variation of BLD. While BLD places the rectangles in decreasing order of height, width, area, and perimeter, BLD* successively tries random orderings, chosen from a distribution determined by their Kendall-tau distance from one of these fixed orderings. Our experiments on benchmark problems show that BLD* produces significantly better packings than BLD after only 1 min of computation. Furthermore, we also show that BLD* outperforms recently reported metaheuristics. Furthermore, we observe that people seem able to reason about packing problems extremely well. We incorporate our new algorithms in an interactive system that combines the advantages of computer speed and human reasoning. Using the interactive system, we are able to quickly produce significantly better solutions than BLD* by itself.
Arthritis‐associated changes in flow cytometric characteristics of cultured synovial fibroblasts (1988)

Synovial fibroblasts cultured from patients with rheumatoid or reactive arthritis and from controls were studied by flow cytometry, spectroscopy, and electron microscopy. Analysis of 29 cell lines revealed consistent differences between arthritic and normal fibroblasts. Cells cultured from inflamed synovial tissue exhibited higher autofluorescence than did control fibroblasts, and displayed exceptional light scatter properties in flow cytometry, indicating changes in cytoplasmic structures. Electron microscopic examination of the fibroblasts from arthritic synovial tissue revealed large numbers of round, swollen, laminated, mitochondrion-like bodies, which were not observed in the control fibroblasts. The changes observed by flow cytometry (light scatter and autofluorescence) coincided with the presence of the mitochondrion-like organelles. The strong autofluorescence observed in the arthritic fibroblasts resembled the fluorescence spectrum of mitochondrial flavoproteins. These data suggest that persistent metabolic and structural changes have occurred in the mitochondria of synovial fibroblasts and inflammatory synovial tissue. The usefulness of flow cytometry in identifying such cells is described.
A two-compartment model of pulmonary nitric oxide exchange dynamics (1998)

The relatively recent detection of nitric oxide (NO) in the exhaled breath has prompted a great deal of experimentation in an effort to understand the pulmonary exchange dynamics. There has been very little progress in theoretical studies to assist in the interpretation of the experimental results. We have developed a two-compartment model of the lungs in an effort to explain several fundamental experimental observations. The model consists of a nonexpansile compartment representing the conducting airways and an expansile compartment representing the alveolar region of the lungs. Each compartment is surrounded by a layer of tissue that is capable of producing and consuming NO. Beyond the tissue barrier in each compartment is a layer of blood representing the bronchial circulation or the pulmonary circulation, which are both considered an infinite sink for NO. All parameters were estimated from data in the literature, including the production rates of NO in the tissue layers, which were estimated from experimental plots of the elimination rate of NO at end exhalation (ENO) vs. the exhalation flow rate (VE). The model is able to simulate the shape of the NO exhalation profile and to successfully simulate the following experimental features of endogenous NO exchange: 1) an inverse relationship between exhaled NO concentration and VE, 2) the dynamic relationship between the phase III slope and VE, and 3) the positive relationship between ENO and VE. The model predicts that these relationships can be explained by significant contributions of NO in the exhaled breath from the nonexpansile airways and the expansile alveoli. In addition, the model predicts that the relationship between ENO and VE can be used as an index of the relative contributions of the airways and the alveoli to exhaled NO.
Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals (2020)

To optimize the public health response to coronavirus disease 2019 (COVID-19), we must first understand the antibody response to individual proteins on the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the antibody's cross reactivity to other coronaviruses. Using a panel of 37 convalescent COVID-19 human serum samples, we showed that the magnitude and specificity of responses varied across individuals, independent of their reactivity to seasonal human coronaviruses (HCoVs). These data suggest that COVID-19 vaccines will elicit primary humoral immune responses in naïve individuals and variable responses in those previously exposed to SARS-CoV-2. Unlike the limited cross-coronavirus reactivities in humans, serum samples from 96 dogs and 10 cats showed SARS-CoV-2 protein-specific responses focused on non-S1 proteins. The correlation of this response with those to other coronaviruses suggests that the antibodies are cross-reactive and generated to endemic viruses within these hosts, which must be considered in seroepidemiologic studies. We conclude that substantial variation in antibody generation against coronavirus proteins will influence interpretations of serologic data in the clinical and veterinary settings.
Druckguss aus Messinglegierungen (2019)

Das Druckgießen arbeitet mit metallischen Dauerformen, in denen die Gussteile schnell abkühlen. Dies ermöglicht kurze Taktzeiten und präzise geformte Konturen. Bei niedrig schmelzenden Metallen wie Aluminium, Magnesium und Zink wird das Verfahren daher umfassend eingesetzt. Da die deutlich höheren Schmelzetemperaturen von Kupfer- und Messingwerkstoffen das Formenmaterial jedoch ungleich stärker beanspruchen, fristet das Druckgießen hier ein Nischendasein. Zu Unrecht, wie ein Besuch bei der französischen Druckgießerei Favi zeigt.
Changes in endoneurial fluid pressure, permeability, and peripheral nerve ultrastructure in experimental lead neuropathy (1980)

The dynamics of endoneurial edema were studied by quantifying endoneurial fluid pressure (EFP) during the development of lead neuropathy and correlating these data with changes in blood-nerve barrier permeability and with morphological alterations in nerves, capillaries, and Schwann cells. EFP measured from the sciatic nerve in control Long-Evans rats was 2.1 +/- 1.0 cm H2O. EFP was significantly elevated 7 weeks after animals were started on a diet containing 6% lead carbonate, and it increased progressively until a plateau in pressure was reached between weeks 9 and 11. Thereafter, EFP gradually returned to normal values. The progressive increase in EFP was highly correlated with the extravasation of osmotically active macromolecules, traced by fluorescein isothiocyanate-dextran compounds of graded molecular weight and by horseradish peroxidase (HRP). Electron microscopy revealed extravasation of HRP between endothelial cells, intranuclear inclusions characteristic of lead poisoning in Schwann cell nuclei, demyelination, and remyelination. The observation of intranuclear inclusions consistent with lead deposition in Schwann cells strengthens the hypothesis that extravasated lead in the interstitial fluid causes direct injury to Schwann cells, giving rise to demyelination. Nerve compliance was determined.