gebhart/patrepeval huggingface dataset:
Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice (1999)

Injury to the central nervous system (CNS) elicits an inflammatory response involving activation of microglia, brain macrophages, and astrocytes, processes likely mediated by the release of proinflammatory cytokines. In order to determine the role of interleukin-6 (IL-6) during the inflammatory response in the brain following disruption of the blood-brain barrier (BBB), we examined the effects of a focal cryo injury to the fronto-parietal cortex in interleukin-6-deficient (IL-6-/-) and normal (IL-6+/+) mice. In IL-6+/+ mice, brain injury resulted in the appearance of brain macrophages and reactive astrocytes surrounding the lesion site. In addition, expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and metallothionein-I+II (MT-I+II) were increased in these cells, while the brain-specific MT-III was only moderately upregulated. In IL-6-/- mice, however, the response of brain macrophages and reactive astrocytes was markedly depressed and the number of NSE positive neurons was reduced. Brain damage-induced GM-CSF and MT-I+II expression were also markedly depressed compared to IL-6+/+ mice. In contrast, MT-III immunoreactivity was markedly increased in brain macrophages and astrocytes. In situ hybridization analysis indicates that MT-I+II but not MT-III immunoreactivity reflect changes in the messenger levels. The number of cell divisions was similar in IL-6+/+ and IL-6-/- mice. The present results demonstrate that IL-6 is crucial for the recruitment of myelo-monocytes and activation of glial cells following brain injury with disrupted BBB. Furthermore, our results suggest IL-6 is important for neuroprotection and the induction of GM-CSF and MT expression. The opposing effect of IL-6 on MT-I+II and MT-III levels in the damaged brain suggests MT isoform-specific functions.
Progress of matching network for passive remote hybrid sensor based on SAW resonator (2008)

The matching network is an important section of the passive remote SAWR (surface acoustic wave resonator) hybrid sensor. There were two disadvantages for the classical method to design the matching network: The one was that the matching network reduces the Q factor of match point. The other was the strong mismatch occurs when the impedance of sensing element shifted from the well-matched point. S. Klett et al proposed the well-matched matching network, and improved the Q of match point. This paper researched the low-mismatched matching network deeply.
Influence of Crystal Orientation on Magnetic Properties in 3% Silicon Steel With Ultra-High Tension TiN Coating (2012)

The influence of the tile angle of the [001] out of crystal surface β on iron loss improvement of 3% Si steel single crystals was investigated. This iron loss improvement was caused by tensile stress effect of TiN coating and domain refinement. When β angle was less than 3 degrees, both eddy current loss and hysteresis loss decrease. Extremely low iron loss was obtained, when β angle equal to about 2 degrees. On the other hand, when β angle is more than 3 degrees, the hysteresis loss increased though the eddy current loss decreased by TiN coating. As a result, change in iron loss was small after TiN coating and domain refining. Therefore, it was clarified that the iron loss improving methods, such as domain refining and ultra-high tension coating, were effective especially in grain oriented electrical steel whose β angle is less than 3 degrees.
Remoblization and Injection in Deepwater Depositional Systems: Implications for Reservoir Architecture and Prediction (2000)

Several productive Paleogene deepwater sandstone reservoirs in the North Sea show evidence of having undergone post-depositional remobilization and clastic injection, which can result in major disruption of the primary reservoir distribution (e.g., Alba, Forth/Harding, Balder, and Gryphon fields). Case studies of deepwater sandstones from UK Quadrants 9, 15, 16 and 21 are presented to illustrate the wide spectrum of remobilization features, which range from centimeters (e.g., core-scale) to hundreds of meters (e.g., seismic-scale). Most common are clastic injection structures such as dikes and sills. Sills of massive sand, over 20 m thick, have...
The protein common assembly database (ProtCAD)—a comprehensive structural resource of protein complexes (2022)

Proteins often act through oligomeric interactions with other proteins. X-ray crystallography and cryo-electron microscopy provide detailed information on the structures of biological assemblies, defined as the most likely biologically relevant structures derived from experimental data. In crystal structures, the most relevant assembly may be ambiguously determined, since multiple assemblies observed in the crystal lattice may be plausible. It is estimated that 10-15% of PDB entries may have incorrect or ambiguous assembly annotations. Accurate assemblies are required for understanding functional data and training of deep learning methods for predicting assembly structures. As with any other kind of biological data, replication via multiple independent experiments provides important validation for the determination of biological assembly structures. Here we present the Protein Common Assembly Database (ProtCAD), which presents clusters of protein assembly structures observed in independent structure determinations of homologous proteins in the Protein Data Bank (PDB). ProtCAD is searchable by PDB entry, UniProt identifiers, or Pfam domain designations and provides downloads of coordinate files, PyMol scripts, and publicly available assembly annotations for each cluster of assemblies. About 60% of PDB entries contain assemblies in clusters of at least 2 independent experiments. All clusters and coordinates are available on ProtCAD web site (http://dunbrack2.fccc.edu/protcad).
An extremely thermostable extracellular proteinase from a strain of the archaebacterium Desulfurococcus growing at 88° C (1987)

An organism growing at 88 degrees C that closely resembles Desulfurococcus mucosus produced a single extracellular proteinase. We have purified this enzyme and carried out a preliminary characterization. The proteinase, which is a serine-type enzyme, had a molecular mass of 52,000 Da by SDS/polyacrylamide-gel electrophoresis, but only 10,000-13,000 Da by gel-permeation chromatography. Molecular mass values from sucrose-gradient centrifugation were of the same order as those from SDS/polyacrylamide-gel electrophoresis. It had an isoelectric point of 8.7, and was inhibited by di-isopropyl phosphorofluoridate, phenylmethanesulphonyl fluoride and chymostatin. Substrate-specificity studies suggested a possible preference for hydrophobic residues on the C-terminal side of the splitting point. The thermostability of this enzyme is probably greater than any other reported proteinase (t1/2 at 95 degrees C, 70-90 min; t1/2 at 105 degrees C, 8-9 min). Ca2+ chelation does not appear to be implicated in stabilization of the protein structure. The stability of the Desulfurococcus proteinase was not greatly affected by the presence of reducing reagents (e.g. dithiothreitol), some chaotropic agents (e.g. NaSCN) and some detergents, but activity was lost rapidly at 95 degrees C in the presence of the oxidizing agent NaBO3. Proteolytic activity was readily detected at temperatures up to and including 125 degrees C, although denaturation was very rapid above 115 degrees C. A number of Figures supporting some of the findings reported in this paper have been deposited in supplement SUP 50137 (14 pages) at the British Library Lending Division, Boston Spa, Wetherby, West Yorkshire LS23 7BQ, U.K., from whom copies may be obtained on the terms indicated in Biochem. J. (1987) 241, 5.
Adenoid Cystic Carcinoma: Benefit of Surgery Plus Adjuvant Radiation (2011)

Objective Evaluate the role of adjuvant radiation compared with surgical resection alone in treatment of adenoid cystic carcinoma of the head and neck. In addition, given the varied course and presentation of the disease, to analyze the impact of perineural invasion, margin status, and AJCC Tumor stage on survival. Method Retrospective review of 92 patients treated for adenoid cystic carcinoma of the head and neck between 1978 and 2010 at a single tertiary care academic center. Kaplan‐Meier survival curves and Cox Proportional Hazards Model were used to evaluate the impact of treatment modality and clinical and pathological parameters on survival. Results The oropharynx was the most common site (30.4%). Overall 2‐, 5‐, and 10‐year survival rates were 75%, 51%, and 22%. Mean follow‐up was 75.9 months. All but 3 patients were treated with surgery and 60 out of 92 (65.2%) underwent postoperative radiation. Mean time to recurrence was 45.6 months and occurred in 45 out of 90 patients (50%). Significantly more T3/T4 staged patients underwent surgery plus adjuvant radiation than T1/T2 patients ( P &lt;. 045). Conclusion Despite being classified with more advanced disease (T3/T4 Stage), patients in the surgery plus radiation group had similar outcomes to patients who received surgery alone. Adjuvant radiation should be considered in all patients with adenoid cystic carcinoma of the head and neck.
Retrospective comparison of low molecular weight heparin vs. warfarin vs. oral Xa inhibitors for the prevention of recurrent venous thromboembolism in oncology patients: The Re-CLOT study (2017)

Background There is increasing evidence indicating oral factor Xa inhibitors can be used for secondary prevention of venous thromboembolism. Studies are needed to compare oral factor Xa inhibitors, low molecular weight heparins, and warfarin in the oncology population. The purpose of this study is to evaluate the recurrent venous thromboembolism incidence in oncology patients utilizing oral Xa inhibitors, low molecular weight heparins, or warfarin. Methods Using retrospectively collected data, we compared the recurrent venous thromboembolism incidence in oncology patients taking rivaroxaban/apixaban, enoxaparin, or warfarin with at least three months of follow-up. Patients were included if they had an active cancer, venous thromboembolism, and taking warfarin, enoxaparin, or rivaroxaban/apixaban. The primary endpoint was the first episode of recurrent venous thromboembolism at three months. Secondary endpoints included recurrent venous thromboembolism after six months, major bleeding, and mortality. Results Of 127 venous thromboembolism patients, 48 received rivaroxaban or apixaban, 23 received enoxaparin, and 56 received warfarin. The three most common cancer diagnoses were lung (21%), colorectal (14%), and breast (14%). There was no difference in venous thromboembolism recurrence at three months between the rivaroxaban/apixaban (0%), warfarin (3.6%), and the enoxaparin cohorts (4.4%) (p = 0.8319). Major bleeding at three months was only seen in one patient in the enoxaparin arm (4.2%). Mortality at three months was 0%, 3.6%, and 17.4% in the rivaroxaban/apixaban, warfarin, and enoxaparin cohorts, respectively. Conclusion The results of this retrospective study suggest that oral factor Xa inhibitors are potential options for cancer patients with venous thromboembolism. However, randomized, controlled trials are needed to confirm these results.
New Therapy for Refractory Chronic Mechanical Low Back Pain—Restorative Neurostimulation to Activate the Lumbar Multifidus: One Year Results of a Prospective Multicenter Clinical Trial (2017)

Electrical stimulation to elicit episodic lumbar multifidus contraction is a new treatment option for CMLBP. Results demonstrate clinically important, statistically significant, and lasting improvement in pain, disability, and QoL.
EEG-based drowsiness estimation for safety driving using independent component analysis (2005)

Preventing accidents caused by drowsiness has become a major focus of active safety driving in recent years. It requires an optimal technique to continuously detect drivers' cognitive state related to abilities in perception, recognition, and vehicle control in (near-) real-time. The major challenges in developing such a system include: 1) the lack of significant index for detecting drowsiness and 2) complicated and pervasive noise interferences in a realistic and dynamic driving environment. In this paper, we develop a drowsiness-estimation system based on electroencephalogram (EEG) by combining independent component analysis (ICA), power-spectrum analysis, correlation evaluations, and linear regression model to estimate a driver's cognitive state when he/she drives a car in a virtual reality (VR)-based dynamic simulator. The driving error is defined as deviations between the center of the vehicle and the center of the cruising lane in the lane-keeping driving task. Experimental results demonstrate the feasibility of quantitatively estimating drowsiness level using ICA-based multistream EEG spectra. The proposed ICA-based method applied to power spectrum of ICA components can successfully (1) remove most of EEG artifacts, (2) suggest an optimal montage to place EEG electrodes, and estimate the driver's drowsiness fluctuation indexed by the driving performance measure. Finally, we present a benchmark study in which the accuracy of ICA-component-based alertness estimates compares favorably to scalp-EEG based.
A library of universal data models by industry types (2001)

Foreword. Acknowledgments. About the Author. Introduction. Manufacturing. Telecommunications. Health Care. Insurance. Financial Services. Professional Services. Travel. E-Commerce Models. Using the Industry Models in the Real World. Appendix A: Entities and Attributes for Manufacturing Models. Appendix B: Entities and Attributes for Telecommunications Models. Appendix C: Entities and Attributes for Health Care Models. Appendix D: Entities and Attributes for Insurance Models. Appendix E: Entities and Attributes for Financial Services Models. Appendix F: Entities and Attributes for Professional Services Models. Appendix G: Entities and Attributes for Travel Models. Appendix H: Entities and Attributes for E-Commerce Models. Appendix I: List of Entities and Their Associated Figures. How to Use the Volume 2 Industry Electronic Products. Index.
A Novel Norditerpenoid from the Okinawan Soft Coral Sinularia Sp. (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Novel Norditerpenoid from the Okinawan Soft Coral Sinularia Sp.Noboru Shoji, Akemi Umeyama, and Shigenobu AriharaCite this: J. Nat. Prod. 1993, 56, 9, 1651–1653Publication Date (Print):September 1, 1993Publication History Published online1 July 2004Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/np50099a035https://doi.org/10.1021/np50099a035research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PROLONGED STORAGE EFFECTS ON THE ARTICULAR CARTILAGE OF FRESH HUMAN OSTEOCHONDRAL ALLOGRAFTS (2003)

These data demonstrate that fresh human osteochondral allograft tissue stored for more than fourteen days undergoes significant decreases in chondrocyte viability, viable cell density, and metabolic activity, with preservation of glycosaminoglycan content and biomechanical properties. The cartilage matrix is preserved during storage for twenty-eight days, but the chondrocytes necessary to maintain the matrix after transplantation decreased over that time-period.
Temperature Dependent Resistivity of Chiral Single-Walled Carbon Nanotubes in the Presence of Coherent Light Source (2021)

We have studied the axial resistivity of chiral single-walled carbon nanotubes (SWCNTs) in the presence of a combined direct current and high frequency alternating fields. We employed semiclassical Boltzmann equations approach and compared our results with a similar study that examined the circumferential resistivity of these unique materials. Our work shows that these materials display similar resistivity for both axial and circumferential directions and this largely depends on temperature, intensities of the applied fields and material parameters such as chiral angle. Based on these low-temperature bidirectional conductivity responses, we propose chiral SWCNTs for design of efficient optoelectronic devices.
Lock-in and quasiperiodicity in a hydrodynamically self-excited jet (2012)

This conference is the nineth in the series started in Cambridge in 1991 and continued in Warsaw (1994), Göttingen (1997), Eindhoven (2000), Toulouse (2003), Stockholm (2006), Manchester (2008) and Munchen (2010). The conference aims at covering the whole field of Fluid Dynamics, comprising from most fundamental aspects to recent applications. It provides a world-wide forum for scientists to meet each other and exchange information of all areas of fluid mechanics.
Abdominal Decompression after Cardiac Surgery: Outcome of 42 Patients with Abdominal Compartment Syndrome (2021)

Abdominal compartment syndrome is a rare but serious complication after cardiac surgery with a high mortality rate. Independent risk factors for ACS were identified. Negative pressure wound therapy seems to promote and allow early fascia closure of the abdomen and represents therefore a likely benefit for the patient.
Presence of Human Epidermal Growth Factor in Human Cerebrospinal Fluid* (1982)

Human epidermal growth factor (gEGF), a potent stimulator of the growth of many tissues in culture, has been isolated from human urine and subsequently identified in many human biological fluids. We have partially purified and characterized hEGF-like substance(s) from human cerebrospinal fluid (CSF) and determined the concentrations of immunoreactive (IR) hEGF in CSF obtained from patients with a variety of neurological diseases. Competitive binding curves generated by the CSF samples appeared to be parallel to standard hEGF both in RIA and radioreceptor assays using human placental membrane. Sephadex G-50 gel exclusion chromatography of the CSF extract revealed a single peak of IR-hEGF which coeluted with standard hEGF. The apparent mol wt of the CSF hEGF-like substances(s) was estimated to be 8000 by sodium dodecyl sulfate poplyacrylamide gel electrophoresis, and its approximate pI was 4.5 as determined by isoelectric focusing. The concentrations of IR-hEGF in CSF from patients with pituitary and brain tumors and radiculomyelopathy were significantly higher than those from control subjects, while neither patients with hydrocephalus nor encephalomeningitis had CSF IR-hEGF levels statistically different from the control subjects. The presence of hEGF-like substance(s) in human CSF suggests that it may play an important physiological role in the function of the human nervous tissues but does not provide any evidence of its source.
Comprehension Assistant for Languages of Baltic States (2007)

Proceedings of the 16th Nordic Conference &#13;\nof Computational Linguistics NODALIDA-2007.&#13;\nEditors: Joakim Nivre, Heiki-Jaan Kaalep, Kadri Muischnek and Mare Koit.&#13;\nUniversity of Tartu, Tartu, 2007.&#13;\nISBN 978-9985-4-0513-0 (online)&#13;\nISBN 978-9985-4-0514-7 (CD-ROM)&#13;\npp. 167-174.
Quantum Local Search for Graph Community Detection (2019)

We present Quantum Local Search (QLS) approach and demonstrate its efficacy by applying it to the problem of community detection in real-world networks. QLS is a hybrid algorithm that combines a classical machine with a small quantum device. QLS starts with an initial solution and searches its neighborhood, iteratively trying to find a better candidate solution. One of the main challenges of the quantum computing in NISQ era is the small number of available qubits. QLS addresses this challenge by using the quantum device only for the neighborhood search, which can be restricted to be small enough to fit on near-term quantum device. We implement QLS for modularity maximization graph clustering using QAOA on IBM Q Experience as a quantum local solver. We demonstrate the potential for quantum acceleration by showing that existing state-of-the-art optimization solvers cannot find a good solution to the local problems quickly and provide an estimate of how larger quantum devices can improve the performance of QLS.
Classifying Unordered Feature Sets with Convolutional Deep Averaging\n Networks (2017)

Unordered feature sets are a nonstandard data structure that traditional\nneural networks are incapable of addressing in a principled manner. Providing a\nconcatenation of features in an arbitrary order may lead to the learning of\nspurious patterns or biases that do not actually exist. Another complication is\nintroduced if the number of features varies between each set. We propose\nconvolutional deep averaging networks (CDANs) for classifying and learning\nrepresentations of datasets whose instances comprise variable-size, unordered\nfeature sets. CDANs are efficient, permutation-invariant, and capable of\naccepting sets of arbitrary size. We emphasize the importance of nonlinear\nfeature embeddings for obtaining effective CDAN classifiers and illustrate\ntheir advantages in experiments versus linear embeddings and alternative\npermutation-invariant and -equivariant architectures.\n
Effect of Interferon on Virus Production from Isolated Single Cells (1973)

SUMMARY Microdrops were used to isolate interferon treated mouse L cells infected with mengovirus. Three parameters were measured, (1) the time of virus yield, (2) the yield/cell, and (3) the percentage of yielding cells. More than 97% of the control single cells yielded an average of 167 p.f.u./cell with most of them yielding between 11 and 14 h post-infection. Cells treated with interferon yielded later than controls (if at all), and all could be protected to some degree. In both treated and control cells, virus was released over a period of about 15 min. Increasing the multiplicity of infection of challenge virus reduced the effectiveness of a given interferon dose, while increasing the concentration of interferon increased the length of the latent period, decreased the size of the yield, and decreased the number of yielding cells. On the basis of these observations it is proposed that (1) the direct effect of interferon protection is to delay a critical step in virus synthesis, (2) the reduction in yield size and in the number of yielders is due to a progressive loss of the inherent ability of the cell to produce virus, and (3) the delay is the result of interferon, or a molecule induced by it, acting as a competitive inhibitor of some cellular or virus product, needed for the completion of virus synthesis.
Robust Manipulation of Magnetism in Dilute Magnetic Semiconductor (Ga,Mn)As by Organic Molecules (2015)

Surface adsorption of organic molecules provides a new method for the robust manipulation of ferromagnetism in (Ga,Mn)As. Electron acceptor and donor molecules yield significant enhancement and suppression, respectively, of ferromagnetism with modulation of the Curie temperature spanning 36 K. Dip-pen nanolithography is employed to directly pattern monolayers on (Ga,Mn)As, which is presented as a novel pathway toward producing magnetic nanostructures.