gebhart/patrepeval huggingface dataset:
Mapping QTL for grain yield, yield components, and spike features in a doubled haploid population of bread wheat (2011)

A doubled haploid (DH) population derived from a cross between the Japanese cultivar 'Fukuho-kumogi' and the Israeli wheat line 'Oligoculm' was used to map genome regions involved in the expression of grain yield, yield components, and spike features in wheat (Triticum aestivum L). A total of 371 markers (RAPD, SSR, RFLP, AFLP, and two morphological traits) were used to construct the linkage map that covered 4190 cM of wheat genome including 28 linkage groups. The results of composite interval mapping for all studied traits showed that some of the quantitative trait loci (QTL) were stable over experiments conducted in 2004 and 2005. The major QTL located in the Hair-Xpsp2999 interval on chromosome 1A controlled the expression of grains/spike (R(2) = 12.9% in 2004 and 22.4% in 2005), grain weight/spike (R(2) = 21.4% in 2004 and 15.8% in 2005), and spike number (R(2) = 15.6% in 2004 and 5.4% in 2005). The QTL for grain yield located on chromosomes 6A, 6B, and 6D totally accounted for 27.2% and 31.7% of total variation in this trait in 2004 and 2005, respectively. Alleles inherited from 'Oligoculm' increased the length of spikes and had decreasing effects on spike number. According to the data obtained in 2005, locus Xgwm261 was associated with a highly significant spike length QTL (R(2) = 42.33%) and also the major QTL for spikelet compactness (R(2) = 26.1%).
CsF in Organic Synthesis. A Practical Method for Inversion of Secondary Mesylates (1995)

The virtually perfect inversion of secondary mesylates by a variety of nucleophiles is effected through promotion by CsF in DMF.
Selective Creation of Thermal Injury Zones in the Superficial Musculoaponeurotic System Using Intense Ultrasound Therapy (2007)

In human cadaveric facial tissue, IUS can noninvasively target and selectively produce TIZs of reproducible location, size, and geometry in the SMAS layer. The ability to produce focused thermal collagen denaturation in the SMAS to induce shrinkage and tissue tightening has not been previously reported and has significant implications for aesthetic facial rejuvenation.
Visual Human Tracking in Wireless Cameras Networks A SURF-Based Approach (2011)

In wireless camera networks, the communication load between cameras is a major concern for visual tracking. To save the bandwidth, traditional applications transfer the spatial coordinates under the precondition of camera calibration, which is computationally unreasonable for large and mobile camera networks. In this chapter, we exploit the use of distinctive and fast to compute local features to represent the non-rigid targets. Transmission of feature descriptors between cameras is done without any calibration. Combining the haar-like patterns and relative color information, our local features succeed to re-identify and relocate the target among the distributed cameras. Furthermore, efficient interest point detection and matching scheme are proposed for the visual tracking under real-time constraints.
Field Treatment of Actinic Keratosis With Ingenol Mebutate. (2016)

There is a need for early, effective field treatments for actinic keratosis (AK) that target subclinical as well as clinically visible lesions to minimize the recurrence and emergence of new lesions. Ingenol mebutate gel is an effective and well-tolerated topical field therapy that has demonstrated sustained clearance and long-term reduction of AKs. This article reviews findings from the FIELD study program and highlights health-related quality of life (HRQoL) outcomes for patients receiving ingenol mebutate. Efficacy data from the FIELD study program are discussed and the tolerability profile of ingenol mebutate in the treatment of areas of up to 100 cm2 is considered. These findings are then placed in the context of HRQoL outcomes and their relevance for patients.<br /><br /> <em>J Drugs Dermatol</em>. 2016;15(5):535-542.
Simplified selective decontamination of the digestive tract reduces Gram-negative bloodstream infection and respiratory tract colonization in intensive care (2012)

Background: Most clinical trials of sepsis treatment modalities fail at their primary objective of establishing superiority over placebo when added to background standard of care. While there is no definitive explanation for the high failure rate, it might be stated that our attempts to insert a new therapeutic agent into standard of care encounters severe problems with definition of exactly what stage is ongoing, and what are the criteria for progression or resolution from that time point onwards. Clearly there is need for a means of defining steps in the septic process that would apply to individuals, and to better define the course of sepsis in each patient after they are enrolled in a trial. Methods: For core model development, 30 septic patients were studied for time-related progression in relation to biomarkers, employing a Load Model in a neural net algorithm in MatLab. Causative bacterial infections were linked to primary infection sites. In order to minimize overparameterization, the model was allowed to estimate outputs using the best three input parameters. Bacterial load was tracked from origin using clinical and microbiologic data to provide an estimate at the start of sepsis. The bacterial load as well as clinical and laboratory parameters were model inputs with the output parameter being organ failures and/ or mortality. Results: At onset of sepsis, human bacterial load estimates ranged from between 10 8 and 10 11 CFU, which is consistent with inocula in animal models of sepsis. Sepsis proceeds to organ failures and mortality in a series of steps that are initially linked to bacterial load and inflammatory response, followed by coagulopathy, ischemia, oxygen deprivation in organs and tissues, and culminating in organ failures. The later stages of sepsis are all driven by metabolic parameters, and there seems to be little benefit to blocking inflammation at later stages. Substrate and oxygen deficiencies must be addressed first. Conclusion: Neural net progression models based on biomarkers and physiological markers are able to describe the evolution of sepsis to septic shock, organ failures, and provide some evidence that mortality may be a consequence of the stages of sepsis. Overall, these models appear useful to the task of sorting out organ failure endpoints and mechanisms in individual patients with sepsis progression across sepsis to septic shock.
Multiple Hemopoietic Defects and Lymphoid Hyperplasia in Mice Lacking the Transcriptional Activation Domain of the c-Rel Protein (1998)

The c-rel protooncogene encodes a member of the Rel/nuclear factor (NF)-kappaB family of transcriptional factors. To assess the role of the transcriptional activation domain of c-Rel in vivo, we generated mice expressing a truncated c-Rel (Deltac-Rel) that lacks the COOH-terminal region, but retains a functional Rel homology domain. Mice with an homozygous mutation in the c-rel region encoding the COOH terminus of c-Rel (c-relDeltaCT/DeltaCT) display marked defects in proliferative and immune functions. c-relDeltaCT/DeltaCT animals present histopathological alterations of hemopoietic tissues, such as an enlarged spleen due to lymphoid hyperplasia, extramedullary hematopoiesis, and bone marrow hypoplasia. In older c-relDeltaCT/DeltaCT mice, lymphoid hyperplasia was also detected in lymph nodes, liver, lung, and stomach. These animals present a more severe phenotype than mice lacking the entire c-Rel protein. Thus, in c-relDeltaCT/DeltaCT mice, the lack of c-Rel activity is less efficiently compensated by other NF-kappaB proteins.
Applied text generation (1992)

Article Free Access Share on Applied text generation Authors: Owen Rambow University of Pennsylvania, Philadelphia, PA University of Pennsylvania, Philadelphia, PAView Profile , Tanya Korelsky CoGenTex, Inc., Ithaca, NY CoGenTex, Inc., Ithaca, NYView Profile Authors Info & Claims ANLC '92: Proceedings of the third conference on Applied natural language processingMarch 1992 Pages 40–47https://doi.org/10.3115/974499.974508Published:31 March 1992Publication History 20citation419DownloadsMetricsTotal Citations20Total Downloads419Last 12 Months8Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ChemInform Abstract: VINYL ESTERS OF PHOSPHORUS ACIDS. XVI. CHEMICAL PROPERTIES OF ALKYL(ALKEN‐1‐YL) CHLOROPHOSPHITES (1979)

Abstract Ethyl‐dichlorphosphit (I) reagiert mit Monochloraceton, Dichloraceton (IV) oder α‐Ketopropionsäurenitril (VII) zu trennbaren Gemischen aus Ethyl‐monovinylchlorphosphiten (II), (V) und (VIII) und Ethyl‐divi‐ 0"! nyl‐phosphiten (III), (VI) und (IX).
Development of Bi-Based Pb-Free Solders for High-Temperature (2012)

Bi-based alloys were investigated for their potential to replace Pb-based solders for high-temperature applications. It is found that Bi–Ag, Bi–Sn and Bi–Zn alloys improve the mechanical properties of the solder, especially Bi–Zn alloy, which shows good workability for wire extrusion. In addition, Bi–Zn alloy has good wettability on Ag-plated substrates and prevents the surplus Bi–Ni reaction in the soldering process. As a result, Bi–Zn alloys with a solidus temperature of 255C are proposed as Pb-free solders for high-temperature applications.
Numerical Simulation for a Nonlinear Deformable Structure Interacting with Free Surface (2011)

The present research develops a numerical fluid?structure interaction (FSI) code based on CFDShip-Iowa version 4, a general-purpose URANS/DES overset fluid solver, and the nonlinear FEM structure solver. The gluing method is applied to transfer the forces and displacements on non-matching grids for fluid and structure domains. The linear FEM solver is applied to deform the boundary layer grid with large deformation in the fluid domain. Deformation of an interior point in the boundary layer grid is obtained using linear interpolation. As the nonlinear deformation problem three sloshing tanks with an elastic bar clamped to its bottom or top are simulated and compared with the experiments and other numerical simulation (PFEM) results. The present simulation results show reasonable agreement with the experiments for bar deformation and free surface elevation.
Predictors of access to pituitary tumor resection in the United States, 1988–2005 (2009)

Racial and socioeconomic factors play a significant role in the admission of patients to high-volume pituitary surgery centers. This study demonstrates potential key policy areas for meaningful intervention to help ease disparities in access to quality care for surgical pituitary disease.
Spectral phase shaping for high resolution CARS spectroscopy around 3000 cm-1 (2009)

By spectral phase shaping of both the pump and probe pulses in coherent anti-Stokes Raman scattering (CARS) spectroscopy we demonstrate the extraction of the frequencies of vibrational lines using an unamplified oscillator. Furthermore we demonstrate chemically selective broadband CARS microscopy on a mixed sample of 4 &mu;m diameter polystyrene (PS) and poly(methyl methacrylate) (PMMA) beads. The CARS signal from either the PS or the PMMA beads is shown to be enhanced or suppressed, depending on the phase profile applied to the broadband spectrum. Using a combination of negative and positive (sloped) &pi;-phase steps in the pump and probe spectrum the purely non-resonant background signal is removed.
Ray-tracing urban macrocell propagation statistics and comparison with WINNER II/&#x002B; measurements and models (2012)

This paper combines measured 3D basestation (BS) and user handheld antenna radiation patterns with a state-of-the-art 3D ray-tracing tool in order to derive a set of urban macrocell propagation statistics suitable for Long Term Evolution (LTE) cellular network planning. Results are presented as cumulative distribution functions (CDFs) and as a function of distance from the BS. Best-fit normal and lognormal distribution parameters are also presented. Ray-tracing is compared with measurements and models from the WINNER II and WINNER+ standards, demonstrating the limitations of the empirical “one size fits all” standardised models. We conclude that site-specific models, which are able to factor in the impact of specific BS and user handheld antenna patterns and geometries or different propagation environments and terrains, offer significant advantages when designing an efficient LTE cellular network.
The case for aspect-oriented reflective middleware (2007)

The emergence of applications domains such as pervasive and autonomic computing has increased the need for customisation and dynamic adaptation of both distributed systems, and the underlying middleware platforms. Two highly complementary technologies have been advocated to meet these challenges, namely: aspect oriented programming (AOP) and reflective middleware. However, these have so far been considered in isolation, or typically target a particular middleware challenge e.g. using aspects to customise a middleware implementation; or using reflection (or dynamic AOP) to alter runtime behaviour. We believe that in combination these technologies better support the engineering of dynamic distributed systems. In this paper, we explore how aspects and reflection have been utilised in both the programming language and middleware communities; building upon this work, we identify four core relationships that form the basis of our model for aspect-oriented reflective middleware. We then explore the potential of this model to i) increase support for the engineering of dynamic reconfigurations, and ii) improve the performance of adaptive systems.
A decrease in physician reimbursement for hormone therapy in prostate cancer and patterns of utilization. (2011)

University of Minnesota M.S. thesis. May 2011. Major: Health services research, policy, and administration. Advisor: Beth A. Virnig, M.P.H., Ph.D., 1 computer file (PDF); vi, 30 pages, appendix p. 28-30.
Overview of series connected flexible AC transmission systems (FACTS) (2013)

Static series compensation devices provide additional flexibility in the operation of transmission lines. Many articles have been published in literature which demonstrate how static series connected FACTS devices can solve numerous power system problems. However, they are not widely utilized in the power industry. The complexity and cost of these devices make it hard to justify their installation. The paper presents the various applications of series connected FACTS devices and the controllers used in literature. It also presents a comparison between fixed and static series compensation device. The paper also explores the economic challenges of installing series connected FACTS devices on the electric power system and some possible economic solutions. A cost effective solution to implement static phase shifting at the neutral of power transformers is presented.
Adversarial vulnerability for any classifier (2018)

Despite achieving impressive performance, state-of-the-art classifiers remain highly vulnerable to small, imperceptible, adversarial perturbations. This vulnerability has proven empirically to be very intricate to address. In this paper, we study the phenomenon of adversarial perturbations under the assumption that the data is generated with a smooth generative model. We derive fundamental upper bounds on the robustness to perturbations of any classification function, and prove the existence of adversarial perturbations that transfer well across different classifiers with small risk. Our analysis of the robustness also provides insights onto key properties of generative models, such as their smoothness and dimensionality of latent space. We conclude with numerical experimental results showing that our bounds provide informative baselines to the maximal achievable robustness on several datasets.
Inhibition of renal sympathetic activity and heart rate by vasopressin in hemorrhaged diabetes insipidus rats (1990)

Hypotensive hemorrhage paradoxically decreases renal sympathetic nerve activity (SNA) and heart rate (HR) in normal rats. Interruption of vagal reflexes by cervical vagotomy prevents these inhibitory responses but does not unmask expected increases in either renal SNA or HR. Arginine vasopressin (AVP), which increases markedly during hemorrhage, may also exert an inhibitory action on responses of renal SNA and HR to hemorrhage. We tested the hypothesis that inhibition of renal SNA and HR by hemorrhage is absent in AVP-deficient diabetes insipidus (DI) rats and is restored by intravenous AVP replacement (1 mU.kg-1.min-1 before hemorrhage and 10 mU.kg-1.min-1 during hemorrhage). We also determined whether vagotomy unmasks significant increases in renal SNA and HR during hemorrhage in DI rats and whether AVP replacement prevents these increases. Under chloralose anesthesia, hemorrhage to 50 mmHg mean arterial pressure for 8 min did not decrease renal SNA or HR in AVP-deficient DI rats but decreased (P less than 0.05) renal SNA and HR in normal Long-Evans rats and in DI rats receiving AVP replacement. After vagotomy, hemorrhage increased (P less than 0.05) renal SNA and HR in AVP-deficient DI rats but did not alter renal SNA or HR in Long-Evans rats and AVP-treated DI rats. Thus renal SNA and HR during hemorrhage were consistently higher (P less than 0.05) in AVP-deficient DI rats compared with Long-Evans or AVP-treated DI rats both before and after vagotomy. In addition, vagotomy attenuated the inhibitory action of AVP on the response of HR but not the response of renal SNA to hemorrhage in DI rats.(ABSTRACT TRUNCATED AT 250 WORDS)
A Design for Additive Manufacturing Ontology (2017)

Design for additive manufacturing (DFAM) gives designers new freedoms to create complex geometries and combine parts into one. However, it has its own limitations, and more importantly, requires a shift in thinking from traditional design for subtractive manufacturing. There is a lack of formal and structured guidelines, especially for novice designers. To formalize knowledge of DFAM, we have developed an ontology using formal web ontology language (OWL)/resource description framework (RDF) representations in the Protégé tool. The description logic formalism facilitates expressing domain knowledge as well as capturing information from benchmark studies. This is demonstrated in a case study with three design features: revolute joint, threaded assembly (screw connection), and slider–crank. How multiple instances (build events) are stored and retrieved in the knowledge base is discussed in light of modeling requirements for the DFAM knowledge base: knowledge capture and reuse, supporting a tutoring system, integration into cad tools. A set of competency questions are described to evaluate knowledge retrieval. Examples are given with SPARQL queries. Reasoning with semantic web rule language (SWRL) is exemplified for manufacturability analysis. Knowledge documentation is the main objective of the current ontology. However, description logic creates multiple opportunities for future work, including representing and reasoning about DFAM rules in a structured modular hierarchy, discovering new rules with induction, and recognizing patterns with classification, e.g., what leads to “successful” versus “unsuccessful” fabrications.
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells (2018)

Overall, we provide evidence that azoles exert their effect by targeting genes and pathways regulated by HK2. These findings shed light on the action of azoles in GBM. Combined with existing literature and preclinical results, these data support the value of repurposing azoles in GBM clinical trials.
Verification of Autonomous Systems for Space Applications (2006)

Autonomous software, especially if it is based on model, can play an important role in future space applications. For example, it can help streamline ground operations, or, assist in autonomous rendezvous and docking operations, or even, help recover from problems (e.g., planners can be used to explore the space of recovery actions for a power subsystem and implement a solution without (or with minimal) human intervention). In general, the exploration capabilities of model-based systems give them great flexibility. Unfortunately, it also makes them unpredictable to our human eyes, both in terms of their execution and their verification. The traditional verification techniques are inadequate for these systems since they are mostly based on testing, which implies a very limited exploration of their behavioral space. In our work, we explore how advanced V&V techniques, such as static analysis, model checking, and compositional verification, can be used to gain trust in model-based systems. We also describe how synthesis can be used in the context of system reconfiguration and in the context of verification
Cost allocations to meet the challenges of today & tomorrow. (1995)

Home care agencies need to plan their position in the industry carefully and consider all available options for organizing their operations and allocating costs. This article outlines some of the many options for cost allocations.
ASCUS, Mature Metaplastic Type (2001)

To study the cytologic criteria for follow-up of mature metaplastic cells within the atypical squamous cells of undetermined significance (ASCUS) category.Squamous epithelial abnormalities between January 1994 and June 1997 at our institution totaled 2,632 and included squamous carcinoma (1), high grade squamous intraepithelial lesions (278), low grade squamous intraepithelial lesions (875) and ASCUS (1,478). From the ASCUS group, 134 (9.06%) were metaplastic; 89 were selected for review. Criteria for case selection were follow-up with tissue biopsy or at least two Pap smears and no previous epithelial abnormality. Patients ranged from 27 to 70 years of age. Parameters tabulated included number of abnormal cells per slide, their architecture, cell size, shape, cytoplasmic hue and texture, nuclear size and contour, chromatin pattern and nucleoli. Additionally, specimens were reviewed for hormonal status and inflammation. The findings were correlated with follow-up data.Cells generally appeared single or in loose, monolayered sheets of three to seven cells per group. The cells were well demarcated, polygonal or oval and ranged from 11 to 30 microns with cyanophilic or eosinophilic thickened cytoplasm. The round to oval nuclei with slight irregularity showed a minimally increased nuclear/cytoplasmic ratio with stippled chromatin. Upon review, 69 smears were confirmed as ASCUS-M. Follow-up revealed 42 with benign findings, 9 with persistent ASCUS/ASCUS-M and 18 with low grade squamous intraepithelial lesions.In mature metaplastic cells with minimal atypia in patients with no previous or concurrent dysplasia, the follow-up details were similar to those described for ASCUS-superficial/immediate squamous cells. These patients could be followed conservatively.