gebhart/patrepeval huggingface dataset:
Cancellation of timing and amplitude jitter in symmetric links using highly dispersed pulses (2001)

We study the properties of symmetric dispersion compensation in optical links using highly dispersed pulse transmission. We show analytically that by splitting the dispersion compensation equally between the input and output of the link, complete cancellation of the timing and amplitude jitter can be obtained in systems where the power profile is symmetric about the center. We explain the dynamics of this cancellation and show, theoretically and experimentaily, that with practical system parameters, symmetric compensation may lead to a considerable improvement in performance.
[Antitumor activity of Lactobacillus casei YIT 9018 (LC 9018)--effect of administration route]. (1984)

Antitumor activity of lactobacilli on Sarcoma 180 was investigated and was shown to be different from strain to strain. In general, Lactobacillus casei had higher antitumor activity compared with other species of lactobacilli. Among these, L. casei YIT 9018 (LC 9018) had significant antitumor activity against Meth A fibrosarcoma when administered into BALB/c mice intravenously, intraperitoneally, subcutaneously, intratumorally or orally. LC 9018 showed antitumor activity against rat ascites hepatoma by intravenous or oral administration, but this activity was lower than that against Meth A in mice.
Spatially resolved spectroscopy of Cassiopeia A with MECS on board ${\vec Beppo}$SAX (2001)

We have performed the first detailed spatially resolved spectroscopy of Cas A in the 1.6-10 keV energy range, using data taken with the MECS spectrometer on board the BeppoSAX Observatory. The well calibrated point spread function in the central region of the MECS allowed us to perform a spatial deconvolution of the data at full energy resolution. We eventually generated a set of spectra, covering a region of ∼3′ radius around the centre of Cas A. The results obtained by fitting these spectra using a non-equilibrium ionisation plasma model and a power law, improve our knowledge about chemical and physical parameters of the Cas A SuperNova Remnant: (i) a single thermal component is sufficient to fit all the spectra; (ii) kT is rather uniformly distributed with a minimum in the east and a maximum in the west, and no evidence is found for high kT expected from the interaction of the main shock with the ISM; (iii) from the distribution of the values of the ionisation parameter we infer the presence of two distinct components: the first with ne in the range 1-10 cm-3, the second (b) with values ten times higher; if we associate component a to the CSM and component b to the ejecta, the mass ratio indicates a progenitor star that lost only a small fraction of the envelope during its pre-SN life. In this hypothesis the distribution of component b across the remnant suggests that the explosion was not spherically symmetric; (iv) the distribution of abundances indicates that we are detecting a CSM component with almost solar composition, and an ejecta component enriched in heavier elements. Abundances found for α-elements are consistent with the current view that Cas A was produced by the explosion of a massive star. A low overabundance can be an indication that at the moment of the explosion the mass-cut was rather high, locking most of the produced 56 into the stellar remnant.
Characterization of changes in pectin methylesterase expression and pectin esterification during tomato fruit ripening (2000)

The production, accumulation, and in situ location of pectin methylesterase (EC 3.1.11) was examined in ripening fruit of the processing tomato cv. UC82B. Pectin methylesterase detected with a monoclonal antibody (PME-1) first appeared adjacent to seeds in immature green fruit and was later detected only in tissue adjacent to the cuticle (i.e., exopericarp) during ripening. Enzyme-linked immunosorbant assay and Western blot analysis using PME-1 demonstrated that the fresh-market cultivars Celebrity and Better Boy accumulated lower levels of this immunologically detectable pectin methylesterase during maturation than did processing cv. UC82B, and that the immunologically detected pectin methylesterase and the total detectable pectin methylesterase activities of 'Celebrity' and 'Better Boy' increased throughout ripening. In contrast, processing cv. UC82B displayed a total detectable pectin methylesterase activity profile that peaked during the breaker stage, a finding supported immunologically by tissue-printing. To correlate pectin methylesterase expression during ripening to the degree of methylesterification of pectins in exopericarp cell walls, we subjected exopericarp tissue from 'UC82B' fruit to an immunocytochemical and ultrastructure study. Esterified pectin decreased in some regions of the exopericarp cell walls during fruit development but persisted in some regions as well. Less-esterified pectin was localized in the middle lamella of exopericarp cell walls during preripe stages, while in ripe fruit, this labeling was largely absent.Key words: pectin methylesterase (PME), immunocytochemistry, tissue-print, pectin esterification, Lycopersicon esculentum.
Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films (2010)

Stimuli-induced protein phosphorylation plays a vital role in signal transduction and transcriptional activities in eukaryotic cells. This work aims to develop analysis techniques that rapidly detect stimulus-specific intracellular protein phosphorylation and association, with specific emphasis on identifying phosphoproteins associated with p65, a nuclear regulatory factor. The analytical strategy includes immunoprecipitation of the target protein along with its associated proteins, tryptic digestion directly on the antibody beads, on-plate phosphopeptide enrichment for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), and collision-induced dissociation-tandem mass spectrometry (CID-MS/MS) to identify phosphopeptides and phosphorylation sites. Enrichment of the phosphopeptides from the tryptic digest occurs on a polymer-oxotitanium-modified gold wafer (Au-P-oxoTi) and consumes as little as 1 microL of digest solution. The Au-P-oxoTi wafers can capture both mono- and multiphosphorylated peptides from model protein digests containing high concentrations of nonphosphopeptides, urea, and salts. When combined with MALDI-MS/MS, the enrichment technique reveals nine phosphopeptides from p65-associated proteins immunoprecipitated from human acute monocytic leukemia (THP-1) cell nuclear extracts. Semiquantitative MALDI-MS shows that the levels of these proteins increase dramatically after treatment with tumor necrosis factor (TNF)-alpha. Overall, these techniques facilitated the identification of five p65-associated proteins, two of which were not previously reported to interact with p65.
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom. (1999)

A comparative study was performed on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic activities of Micrurus nigrocinctus venom. Both antivenoms were adjusted to a similar neutralizing potency in experiments where venom and antivenoms were preincubated prior to injection. No significant differences were observed between IgG and F(ab')2 antivenoms concerning neutralization of lethal effect in rescue experiments, i.e., when antivenom was administered intravenously after envenomation. However, F(ab')2 antivenom was more effective in prolonging the time of death when subneutralizing doses were administered immediately after venom injection. Both products partially reversed the binding of M. nigrocinctus alpha-neurotoxins to acetylcholine receptor in vitro. The IgG and F(ab')2 antivenoms effectively neutralized venom-induced myotoxicity when administered intravenously immediately after envenomation, although neutralization was poor if antivenom injections were delayed. Intramuscular injection of venom promoted diffusion of antivenom antibodies throughout muscle tissue, and F(ab')2 diffused to a higher extent than IgG molecules. Thus, despite the observation that F(ab')2 antivenom was more effective than IgG antivenom in prolonging the time of death when subneutralizing doses were administered immediately after envenomation, no major differences were observed in antivenom neutralization of lethal and myotoxic effects or in their capacity to reverse neurotoxin binding to the acetylcholine receptor.
Recurrent 3D Pose Sequence Machines (2017)

3D human articulated pose recovery from monocular image sequences is very challenging due to the diverse appearances, viewpoints, occlusions, and also the human 3D pose is inherently ambiguous from the monocular imagery. It is thus critical to exploit rich spatial and temporal long-range dependencies among body joints for accurate 3D pose sequence prediction. Existing approaches usually manually design some elaborate prior terms and human body kinematic constraints for capturing structures, which are often insufficient to exploit all intrinsic structures and not scalable for all scenarios. In contrast, this paper presents a Recurrent 3D Pose Sequence Machine(RPSM) to automatically learn the image-dependent structural constraint and sequence-dependent temporal context by using a multi-stage sequential refinement. At each stage, our RPSM is composed of three modules to predict the 3D pose sequences based on the previously learned 2D pose representations and 3D poses: (i) a 2D pose module extracting the image-dependent pose representations, (ii) a 3D pose recurrent module regressing 3D poses and (iii) a feature adaption module serving as a bridge between module (i) and (ii) to enable the representation transformation from 2D to 3D domain. These three modules are then assembled into a sequential prediction framework to refine the predicted poses with multiple recurrent stages. Extensive evaluations on the Human3.6M dataset and HumanEva-I dataset show that our RPSM outperforms all state-of-the-art approaches for 3D pose estimation.
Effects of ω-Functional Groups on pH-Dependent Reductive Desorption of Alkanethiol Self-Assembled Monolayers (2004)

Self-assembled monolayers (SAMs) of alkanethiols having various terminal groups on their omega-positions were formed on a Au111 electrode, and their reductive desorption was studied by linear sweep voltammetry, focusing on effects of solution pH on the desorption behavior. The peak potentials (Ep) of cathodic waves representing reductive desorption were found to be reflected by the pKa value of the thiol group and were negatively shifted with an increase in pH of the electrolyte solution. The magnitude of the pH dependency of Ep was greatly influenced by the hydrophobicity of the terminal groups. In the cases of alkanethiol SAMs having pH-sensitive terminal groups such as carboxyl and amino groups, their basicity was estimated from bending points appearing in the pH titration profile of Ep. This method allows direct determination of not only the pKa value of the arrayed groups but also that of the groups dissolved in solution simultaneously. The pKa values of the arrayed carboxyl groups in SAMs were larger by ca. 3 pH units than their original ones, while those for amino groups were smaller by ca. 2 pH units.
Phenobarbital and Clonidine as Secondary Medications for Neonatal Opioid Withdrawal Syndrome (2021)

Among infants with NOWS receiving morphine and secondary therapy, those treated with phenobarbital had shorter length of hospital stay and shorter morphine treatment duration than clonidine-treated infants but were discharged from the hospital more often on secondary medication. Further investigation is warranted to determine if the benefits of shorter hospital stay and shorter duration of morphine therapy justify the possible neurodevelopmental consequences of phenobarbital use in infants with NOWS.
Analysis of the published calorimetric evidence for electrochemical fusion of deuterium in palladium. Technical report. [Cold fusion] (1989)

Estimates are given of the raw data that are the basis for the claims of excess power production by the electrochemical charging of palladium in deuterium oxide (D2O). Calorimetric results are also presented that show no anomalous power production in either 0.1 M LiOD/D2O or 0.1 M LiOH/H2O (LiOH is lithium hydroxide). Several possible sources of error in open-system calorimetry are discussed that can confound interpretation of temperature changes in terms of anomalous power production.
Asynchronous and Synchronous Delivery Models for Home-Based Cardiac Rehabilitation (2021)

While most studies prior to 2016 involved asynchronous HBCR approaches to care, studies since 2016 have included asynchronous or synchronous delivery models. Both delivery models have been shown to help provide core components of cardiac rehabilitation (CR). Studies using either method have been shown to have similar short-term patient outcomes as CBCR, at least in low- to moderate-risk patients who have been studied. Asynchronous HBCR offers greater flexibility for patients and CR staff, while synchronous HBCR provides greater real-time oversight and feedback to patients.Asynchronous and synchronous HBCR is an option to consider for patients eligible for CR. Additional research is needed for both delivery models, applied separately or in combination, to compare their impact on shorter- and longer-term patient outcomes and to assess their impact in patient subgroups (referral diagnosis, women, elderly, underrepresented racial and ethnic minority groups, patients at a higher cardiovascular disease risk, patients with multiple comorbid conditions, etc).
Characterisation of Glutamate transporters in bone (2000)

Conference Abstract| October 01 2000 Characterisation of Glutamate transporters in bone Jim Huggett; Jim Huggett 1School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff, CF1 3US Search for other works by this author on: This Site PubMed Google Scholar D. J. Mason D. J. Mason 1School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff, CF1 3US Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A391. https://doi.org/10.1042/bst028a391 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Jim Huggett, D. J. Mason; Characterisation of Glutamate transporters in bone. Biochem Soc Trans 1 October 2000; 28 (5): A391. doi: https://doi.org/10.1042/bst028a391 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Optical centralized shared bus architecture for high-performance multiprocessing systems (2003)

With the increasing demand for solving more complex problems, high-performance multiprocessing systems are attracting more and more research efforts. One of the challenges is to effectively support the communications among the processes running in parallel on the multiprocessors. Due to the physical limitations of electrical interconnects, interconnection networks impose a potential bottleneck limiting the overall performance. On the other hand, optics has many advantages as an interconnect technology. In this paper, benefits of optics are evaluated along with a comparison of two mainstream system topologies, shared bus and switched media. This analysis leads to an innovative interconnect architecture, optical centralized shared bus. The crucial design aspects of this architecture, including system organization, working principle, and conversion between free-space propagation and substrate-guided mode propagation by using volume holographic gratings, are delineated. To ensure the feasibility of using this architecture as high ­performance interconnection networks in real multiprocessing systems, a PCI implementation of the centralized shared memory multiprocessor system is proposed. In this prototype, the required connectivity is accomplished by using the optical centralized shared bus architecture. Some preliminary results are presented.
Self supervised contrastive learning for digital histopathology (2021)

Unsupervised learning has been a long-standing goal of machine learning and is especially important for medical image analysis, where the learning can compensate for the scarcity of labeled datasets. A promising subclass of unsupervised learning is self-supervised learning, which aims to learn salient features using the raw input as the learning signal. In this work, we tackle the issue of learning domain-specific features without any supervision to improve multiple task performances that are of interest to the digital histopathology community. We apply a contrastive self-supervised learning method to digital histopathology by collecting and pretraining on 57 histopathology datasets without any labels. We find that combining multiple multi-organ datasets with different types of staining and resolution properties improves the quality of the learned features. Furthermore, we find using more images for pretraining leads to a better performance in multiple downstream tasks, albeit there are diminishing returns as more unlabeled images are incorporated into the pretraining. Linear classifiers trained on top of the learned features show that networks pretrained on digital histopathology datasets perform better than ImageNet pretrained networks, boosting task performances by more than 28% in F1 scores on average. Interestingly, we did not observe a consistent correlation between the pretraining dataset site or the organ versus the downstream task (e.g., pretraining with only breast images does not necessarily lead to a superior downstream task performance for breast-related tasks). These findings may also be useful when applying newer contrastive techniques to histopathology data. Pretrained PyTorch models are made publicly available at https://github.com/ozanciga/self-supervised-histopathology.
Online Recalibration of the State Estimators for a System With Moving Boundaries Using Sparse Discrete-in-Time Temperature Measurements (2017)

In this paper, the problem of estimation is considered for a class of processes involving solidifying materials. These processes have natural nonlinear infinite-dimensional representations, and measurements are only available at particular points in the caster, each corresponding to a single discrete-in-time boundary measurement in the Stefan problem partial differential equation (PDE) mathematical model. The results for two previous estimators are summarized. The first estimator is based on the Stefan problem, using continuous instead of discrete-in-time boundary measurements. The second estimator employs a process model that is more detailed than the Stefan problem, but with no output injection to reduce estimation error, other than model calibration. Both of these estimation frameworks are extended in the current paper to a more realistic sensing setting. First, an estimator is considered that uses the Stefan problem under some simplifying but practically justified assumptions on the unknowns in the process. The maximum principle for parabolic PDEs is employed to prove that online calibration using a single discrete-in-time temperature measurement can provide removal of the estimation error arising due to mismatch of a single unknown parameter in the model. Although unproven, this result is then shown in simulation to apply to the more detailed process model.
Abstract 12770: Left-Atrial Contractile Contribution to Left Ventricle Filling is Preserved in Moderate Chronic Heart Failure (2014)

Introduction: The extent that left atrium (LA) functional remodeling is impacted by left ventricle (LV) systolic function or clinical history in patients with chronic heart failure (HF) is unresolved. Cardiac imaging and plasma biomarkers may provide valuable information in this regard. Hypothesis: Elastic and active contributions to LV stroke volume (LV SV) are variable, independent of LV systolic function and reflected in natriuretic peptide measurements. Methods: We recruited 27 controls without overt cardiovascular disease and 68 patients with moderate HF, including preserved and reduced LV ejection fraction (LVEF). Cardiac MRI was used to evaluate LV volumes at end diastole and end systole, and LA volumes at end diastole, diastasis and end systole to determine passive and active volume changes. Plasma mid-region pro-atrial and N-terminal pro-brain natriuretic peptides (MR-proANP and NT-proBNP, respectively) were measured. Results: Elastic LA contribution to LV SV was significantly lower in HF (median, IQR: 14%, 8-23%) than controls (24%, 17-30%; p=0.001), but active contribution was not (23%, 0-34% vs 24%, 21-31%; p=0.163). In patients with HF, active LA contribution to LV SV was negatively associated with history of hypertension (β=-0.41, p=0.007) and positively associated with aging (β=0.40, p=0.008) in a multiple linear regression model. Seven of nine subjects with HF and a history of atrial fibrillation (AF), but in sinus rhythm (SR) on the day of study, had active LA contributions to LV SV &gt;15%. Increased LA volume at end diastole (β=0.51, p=0.001) and LVEF (β=-0.33, p=0.008) were independently associated with NT-proBNP (β=0.51, p=0.001) in a model that included age and history of AF. Similarly, LA volume at end diastole (β=0.48, p=0.001) was independently associated with MR-proANP in a model that included age and history of AF. Notably, natriuretic propeptides were not associated with elastic or active LA contributions to LV SV. Conclusions: Heart failure is characterized by preserved LA active contribution to LV SV, regardless of LVEF, which increases with age, and is modifiable by hypertension and AF. Imaging-based assessment can elucidate the contribution of LA function in HF and may provide insight into the impact of AF in patients with HF.
Mechanism for displacive excitation of coherent phonons in Sb, Bi, Te, and Ti2O3 (1991)

Coherent phonons in Sb, Bi, Te, and Ti2O3 can be generated impulsively, and detected in the time domain through reflectivity modulation using 60 fs pulses of laser light at 2 eV. Experimental data for these opaque solids suggest that a direct Raman excitation mechanism is not responsible for coherent phonon generation. Rather, the excitation is attributed to an electronically induced displacement of the ion equilibrium coordinates.
プログラミングMicrosoft Windows 2000 : サービスによるサーバーアプリケーション開発 (2000)

第１部 Ｗｉｎｄｏｗｓサーバー機能概要（サービス開発の原則；デバイスＩ／Ｏとスレッド間通信） 第２部 サービス（サービスアプリケーション；サービスコントロールプログラム（ＳＣＰ）） 第３部 管理（システムレジストリ；イベントログ；パフォーマンスモニタリング ほか） 第４部 セキュリティ（トラスティ管理；アクセスコントロール；ユーザーコンテキスト ほか）
Refinerías petroquímicas: válvulas para condiciones de proceso críticas (2002)

Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell according to the state of growth. The reactions responsible for the biosynthesis and interconversion of the polyamines and their precursor putrescine are described and the means by which polyamine content can be varied in response to exogenous stimuli are discussed. The role of polyamines in the cell cycle, cell division, tissue growth, and differentiation is considered. Recent studies using highly specific inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithine to prevent accumulation of polyamines have indicated that the synthesis of polyamines is intimately associated with these processes. Such inhibitors have great potential for investigation of the cellular role of polyamines.