gebhart/patrepeval huggingface dataset:
Deadline-Aware Fast One-to-Many Bulk Transfers over Inter-Datacenter Networks (2019)

An increasing number of cloud services are operated globally, where the service data are frequently replicated across geographically distributed datacenters to improve service quality and reliability. Such replication generates many one-to-many bulk data transfers over inter-datacenter networks from one datacenter to many receiver datacenters. To provide end-users with guaranteed services, these data transfers are usually required to be completed within designated deadlines. Despite the exponential growth in data demand, there has been little work on guaranteeing deadlines for one-to-many transfers, which is the subject of this paper. This paper proposes a centralized admission control coupled with a scheduling algorithm, named deAdline-Guaranteed transfEr (AGE), to guarantee the deadline of admitted data transfers and utilize the network capacity efficiently. The key idea is to flexibly select the source datacenter for receiver datacenters and allow the remaining receivers to obtain a replica from either the original source or the other receivers that have already received a copy. By jointly allocating the source for receivers and the bandwidth and routing paths for every data transfer, AGE maximizes the number of deadline-satisfied transfers. Our simulations show that compared to the state-of-the-art, AGE guarantees the deadline for up to 70 percent more transfers, achieves at least 2× higher network throughput, and reduces the completion time up to 80 percent.
Is a Double‐Bundle PCL Reconstruction, Augmented by Extra‐Articular Reconstruction, Necessary for the Reconstruction of a PCL/PLC Injury? (SS‐57) (2007)

In an in-vitro, cadaveric study of combined PCL/PLC injuries, it has been demonstrated that extra-articular augmentation of intra-articular PCL reconstructions is necessary for the restoration of normal posterior, varus and external rotation laxities. Also, it has been shown that there is little advantage of a double-bundle PCL reconstruction over a single-bundle reconstruction when extra-articular augmentation is used.
Improvement of VHCF Chracteristics of AISI 4137, 52100 & H13 Steel by UNSM Treatment (2011)

There are many surface technologies aimed at improving fatigue strength by inducing big and deep compressive residual stress. The Ultrasonic Nanocrystal Surface Modification (UNSM) technology is one of them. The UNSM technology has been applied to carbon steel AISI1045, chrome molybdenum steel AISI4137, hot tool steel H13 (SKD61) and bearing steel AISI52100. The mechanical properties of these steels before and after UNSM treatment are analyzed and compared. Rotary bending fatigue test until 10 9 cycles(VHCF) is carried out in order to verify the UNSM effects. SEM, ESBD and TEM analysis are performed to investigate the effects of UNSM treatment. The contribution of mechanical properties to fatigue strength improvement is discussed.
Characterization of divIVA and Other Genes Located in the Chromosomal Region Downstream of the dcw Cluster in Streptococcus pneumoniae (2003)

We analyzed the chromosome region of Streptococcus pneumoniae located downstream of the division and cell wall (dcw) cluster that contains the homolog of the Bacillus subtilis cell division gene divIVA and some genes of unknown function. Inactivation of divIVA in S. pneumoniae resulted in severe growth inhibition and defects in cell shape, nucleoid segregation, and cell division. Inactivation of the ylm genes resulted in some morphological and/or division abnormalities, depending on the inactivated gene. Transcriptional analysis revealed a relationship between these genes and the ftsA and ftsZ cell division genes, also indicating that the connection between the dcw cluster and the divIVA region is more extensive than just chromosomal position and gene organization.
Short Communication: Intramammary Infusion of IGF-I Increases Bromodeoxyuridine Labeling in Mammary Epithelial Cells of Prepubertal Heifers (2005)

When dairy heifers are fed to gain more than 900 g of body weight/d, they have less mammary parenchymal DNA at puberty but more insulin-like growth factor-I (IGF-I) in serum. This negative relationship between serum IGF-I concentration and mammary epithelial cell proliferation is in disagreement with the extensively reported role of IGF-I as a stimulator of mammary epithelial cell proliferation. Despite the large body of evidence suggesting that an increase in IGF-I concentration should lead to an increase in mammary epithelial cell proliferation of prepubertal heifers, it had not been previously tested. Our objective was to determine if intramammary infusions of IGF-I would stimulate mammogenesis in prepubertal heifers in vivo. After 7 d of treatment, bromodeoxyuridine was infused intravenously and heifers were slaughtered 3 h later. Samples from 3 regions of the mammary parenchyma were collected, fixed, sliced, and incubated with bromodeoxyuridine monoclonal antibody to identify cells in the S-phase of the cell cycle. Intramammary infusion of IGF-I increased the percentage of epithelial cells in the S-phase by 52% (6.4 vs. 4.2%, +/- 0.3%). Proliferation was similar in all 3 parenchymal regions, and the response to IGF-I was similar in each region. We conclude that local IGF-I increases proliferation of mammary parenchymal epithelial cells in prepubertal heifers.
The discovery of fullerenes in the 1.85 billion-year-old Sudbury meteorite crater (1996)

Fullerenes (C{sub 60}, C{sub 70}) have been identified by laser time-of-flight and electron-ionization mass spectroscopy in rock samples (black tuff in the Onaping formation) from the crater. They were likely synthesized within the impact plume from carbon contained in the meteorite. The isotopic ratios suggest {sup 13}C enrichment. They are associated with sulfur which may have protected them. This is the largest known deposit of naturally occurring fullerenes.
Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells (1998)

A gas-filled microbubble with anti-ICAM-1 antibody on its shell specifically binds to activated ECs overexpressing ICAM-1. Diagnostic ultrasound in conjunction with targeted contrast agents has the unique potential to characterize cell phenotype in vivo.
COWLS: Hardware–Software Cosynthesis of Wireless Low-Power Distributed EmbeddedClient–Server Systems (2004)

In this paper, we present COWLS, a hardware-software cosynthesis algorithm that targets embedded systems composed of servers and low-power clients that communicate with each other through a channel of limited bandwidth, e.g., a wireless link. A novel scheduling algorithm is used to pipeline the execution of tasks that serve multiple clients associated with a given server. COWLS simultaneously optimizes the price of the client-server system, the power consumption of the clients, and the response times of tasks that have only soft deadlines, while meeting all of the hard deadlines. It produces numerous solutions that trade off different architectural features, e.g., price, power consumption, and response time, of an embedded client-server system. As far as we know, this is the first synthesis algorithm of its kind. We present the experimental results for numerous pseudorandom examples, a low-power client-server camera system, as well as the rest of the benchmarks within a publicly released embedded system synthesis benchmark suite.
Disturbance and Friction Compensations in Hard Disk Drives Using Neural Networks (2009)

In this paper, we show that by using two adaptive neural networks (NNs), each of which is tailored for a specific task, the tracking performance of the hard-disk-drive (HDD) actuator can be significantly improved. The first NN utilizes accelerometer signal to detect external vibrations and compensates for its effect on HDD position via feedforward action. The second NN is designed to compensate for pivot friction. The appealing advantage of the NN compensators is that the design does not involve any information on the plant, sensor, disturbance dynamics, and friction model. The stability of the proposed scheme is analyzed by the Lyapunov criterion. Experimental results show that the tracking performance of the HDDs can be improved significantly with the use of the NN compensators as compared to the case without compensation.
ATRP of MIDA Boronate-Containing Monomers as a Tool for Synthesizing Linear Phenolic and Functionalized Polymers (2021)

Despite numerous novel polymeric materials that have been produced by incorporating boronic acid or ester groups into polymers, it remains a challenge to prepare well-defined boronate-containing polymers due to their inherent instability. Herein, we used <i>N</i>-methyliminodiacetic acid (MIDA) to stabilize the reactive organoboron structure. MIDA boronate-containing polymers were synthesized in a good control by initiators for continuous activator regeneration atom transfer radical polymerization (ICAR ATRP). Oxidation and Suzuki-Miyaura coupling were conducted to prepare linear phenol-containing polymers and aromatic functionalized polymers. Upon comparison of similar polymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, of which the chain transfer agent (CTA) end groups cause multiple undesired side reactions, the halogen end groups of polymers prepared by ATRP are nontoxic to metal catalysts and stable during the postmodifications, thus providing a more facile tool for synthesizing various functionalized polymers with great potentials in advanced materials.
Thermodynamic and Structural Consequences of Changing a Sulfur Atom to a Methylene Group in the M13Nle Mutation in Ribonuclease-S (1994)

Two fragments of pancreatic ribonuclease A, a truncated version of S-peptide (residues 1-15) and S-protein (residues 21-124), combine to give a catalytically active complex. We have substituted the wild-type residue at position 13, methionine (Met), with norleucine (Nle), where the only covalent change is the replacement of the sulfur atom with a methylene group. The thermodynamic parameters associated with the binding of this variant to S-protein, determined by titration calorimetry in the temperature range 10-40 degrees C, are reported and compared to values previously reported [Varadarajan, R., Connelly, P. R., Sturtevant, J. M., & Richards, F. M. (1992) Biochemistry 31, 1421-1426] for other position 13 analogs. The differences in the free energy and enthalpy of binding between the Met and Nle peptides are 0.6 and 7.9 kcal/mol at 25 degrees C, respectively. These differences are slightly larger than, but comparable to, the differences in the values for the Met/Ile and Met/Leu pairs. The structure of the mutant complex was determined to 1.85 A resolution and refined to an R-factor of 17.4%. The structures of mutant and wild-type complexes are practically identical although the Nle side chain has a significantly higher average B-factor than the corresponding Met side chain. In contrast, the B-factors of the atoms of the cage of residues surrounding position 13 are all somewhat lower in the Nle variant than the Met wild-type.(ABSTRACT TRUNCATED AT 250 WORDS)
Revised and Updated Recommendations for the Establishment of Primary Stroke Centers (2011)

Based on the evidence, several elements of Primary Stroke Centers are particularly important for improving the care of patients with an acute stroke. Additional elements focus on imaging of the brain, the cerebral vasculature, and the heart. These new elements may improve the care and outcomes for patients with stroke cared for at a Primary Stroke Center.
Confinement of the Triplet States in π‐Conjugated BODIPY Dimers Linked with Ethynylene or Butadiynylene Bridges: A Different View on the Effect of Symmetry (2022)

Abstract Understanding the impact of the excited state wavefunction confinement is crucial for the engineering of the photophysical properties and applications of organic chromophores. In the present contribution, the localization of the triplet state wavefunctions of some symmetric ethyne/butadiyne bridged BODIPY dimers and asymmetric BODIPY derivatives presenting extended π‐conjugation frameworks is studied with time‐resolved electron paramagnetic resonance spectroscopy and time‐dependent density functional theory computations. Based on the Zero Field Splitting D parameters, we conclude that the triplet state wavefunctions are highly localized on one BODIPY unit in the symmetric dimers, which is consistent with the ab initio modelling that finds delocalized triplet state destabilized by 12–14 kcal mol −1 as compared to its localized counterpart. The result provides a new insight into the study of triplet excited state confinement and the design of molecular wires or photosensitizers for photovoltaics and photocatalysis.
Application of passive samplers (pisces) to locating a source of PCBs on the Black River, New York (1993)

Abstract Dissolved hydrophobic chemicals can be concentrated with a passive, in situ concentration-extraction sampler (PISCES), an inexpensive and easy-to-use device made from plumbing parts and polyethylene film. PISCES is intended to mimic the direct uptake of chemicals from water by fish without the complications of metabolism and the uncertainty of location of exposure. This report examines the practical application of PISCES to a problem in identifying the source of PCBs to the Black River (NY). PISCES were deployed on three occasions at stations throughout the length of the river. Solvent recovered from the PISCES was analyzed for polychlorinated biphenyl (PCB) congeners. Relative homolog abundances and absolute amount of recovered PCBs pointed to a particular river reach as a possible source. A fourth set of samples taken in the city of Carthage (NY) defined a plausible source. Conventional sampling methods would not have been effective in this situation.
Modifying min-cut for hardware and software functional partitioning (1997)

The Kernighan/Lin heuristic, also known as min-cut, has been extended very successfully for circuit partitioning over several decades. Those extensions customized the heuristic and its associated data structure to rapidly compute the minimum-cut metric required during circuit partitioning; thus, those extensions are not applicable to problems requiring other metrics. In this paper, we extend the heuristic for functional partitioning in a manner applicable to the codesign problem of hardware/software partitioning as well as to hardware/hardware partitioning. The extension customizes the heuristic and data structure to rapidly compute execution-time and communication metrics, crucial to hardware and software partitioning, and leads to near-linear time-complexity and excellent results. Our experiments demonstrate extremely fast execution times (just a few seconds) with results matched only by the much slower simulated annealing heuristic, meaning that the extended Kernighan/Lin heuristic will likely prove hard to beat for hardware and software functional partitioning.
A Robust Adaptive Notch Filter for Broadband Signal and Its Application (2010)

The adaptive notch filter that is composed of the exponential type all-pass circuit has the stable and the robust characteristics for the broadband signal. In this paper, a method to reduce the degree and the constant delay of the adaptive filter and a adaptive algorithm using the window function are presented. The application to the narrowband signal canceling in the speech signal, the sound noise canceling and the howling signal canceling are also presented.
Gas-permeable ethylene bags for the small scale cultivation of highly pathogenic avian influenza H5N1 and other viruses in embryonated chicken eggs (2010)

For many small-scale applications, ethylene breather bags can be used to encase ECE inoculated with various viruses.
A Phase I Study of the Anti-Idiotype Vaccine Racotumomab in Neuroblastoma and Other Pediatric Refractory Malignancies (2015)

Racotumomab vaccination has a favorable toxicity profile up to a dose of 0.4 mg, and most patients elicited an immune response. Its activity as immunotherapy for neuroectodermal malignancies will be tested in further clinical trials.
In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202 (2005)

CYC202 showed therapeutic activity on human cancer cell lines in vitro and on xenografts. Pharmacodynamic markers are altered in vitro and in vivo, consistent with the inhibition of cyclin-dependent kinases. Such markers may be potentially useful in the clinical development of CYC202 and other cyclin-dependent kinase inhibitors.
Supplementary Data from Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer (2023)

Supplementary Data from Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer
Measured Time Variations of Reflectance for CO_2 Laser Beam Splitters (1970)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Daryl J. Monson, "Measured Time Variations of Reflectance for CO2 Laser Beam Splitters," Appl. Opt. 9, 224-225 (1970) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The morphology of the renal microvasculature in glycerol- and gentamicin-induced acute renal failure. (1983)

To elucidate abnormalities in the renal microvasculature that could account for the functional disturbances occurring in two well-established models of acute renal failure, we gave rats a single intramuscular injection of glycerol (50%, 10 ml/kg) or daily subcutaneous doses of gentamicin (100 mg/kg/day). Afferent arteriolar diameters were determined by measuring methacrylate vascular casts with SEM. The filtration barrier was examined by both SEM and TEM. The EF area was quantitated. By 3 hr, the glycerol treatment markedly decreased PADs and DADs (PAD 19.1 to 12.0 micrometers, DAD 13.8 to 7.4 micrometers, p less than 0.05). The changes were similar for both inner and outer cortical regions. By 3 days the vasoconstriction was alleviated; however, renal failure persisted. At that time, however, EF area was decreased to 43% of normal. After 10 days of gentamicin treatment, only minimal vasoconstriction occurred in the outer cortex; however, EF area was decreased to a similar degree as observed with the 3-day glycerol-treated animals. There are two phases to glycerol-induced acute renal failure. The first phase (described as readily reversible) is characterized by intense vasoconstriction. The second phase, which is not immediately reversible, is associated with a decreased EF area. Smaller outer cortical afferent arterioles and a decreased fenestral diameter and density of the glomerular endothelium are seen only after gentamicin-induced renal failure is well established (after 10 days of treatment).
Induction of Endoplasmic Reticulum Stress in Retinal Pericytes by Glucose Deprivation (2006)

Diabetic retinopathy is one of the major microvascular complications associated with diabetes mellitus, and the selective degeneration of retinal capillary pericytes is considered to be a hallmark of early retinopathy. Because glucose fluctuations commonly occur in diabetes, we hypothesized that these fluctuations will increase the endoplasmic reticulum (ER) stress and induce the unfolded protein response (UPR) in retinal pericytes. To study whether ER stress and the UPR can be induced in retinal pericytes, rat retinal capillary pericytes were cultured in different concentrations of glucose. Hypoglycemia but not hyperglycemia was found to activate UPR-specific enzymes in pericytes. Strong UPR activation leading to apoptosis was also observed when pericytes were cultured in glucose concentrations that were reduced from high to low or no glucose. These results indicate that induction of UPR is related not only to absolute concentrations but also to a shifting from higher to lower concentrations of glucose.
Mathematical Analysis of Maxwell Fluid Flow through a Porous Plate Channel Induced by a Constantly Accelerating or Oscillating Wall (2021)

Exact expressions for dimensionless velocity and shear stress fields corresponding to two unsteady motions of incompressible upper-convected Maxwell (UCM) fluids through a plate channel are analytically established. The porous effects are taken into consideration. The fluid motion is generated by one of the plates which is moving in its plane and the obtained solutions satisfy all imposed initial and boundary conditions. The starting solutions corresponding to the oscillatory motion are presented as sum of their steady-state and transient components. They can be useful for those who want to eliminate the transients from their experiments. For a check of the obtained results, their steady-state components are presented in different forms whose equivalence is graphically illustrated. Analytical solutions for the incompressible Newtonian fluids performing the same motions are recovered as limiting cases of the presented results. The influence of physical parameters on the fluid motion is graphically shown and discussed. It is found that the Maxwell fluids flow slower as compared to Newtonian fluids. The required time to reach the steady-state is also presented. It is found that the presence of porous medium delays the appearance of the steady-state.
HSC70 and HSP90 chaperones perform complementary roles in translocation of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol (2019)

Cholera toxin (CT) travels by vesicle carriers from the cell surface to the endoplasmic reticulum (ER) where the catalytic A1 subunit of CT (CTA1) dissociates from the rest of the toxin, unfolds, and moves through a membrane-spanning translocon pore to reach the cytosol. Heat shock protein 90 (HSP90) binds to the N-terminal region of CTA1 and facilitates its ER-to-cytosol export by refolding the toxin as it emerges at the cytosolic face of the ER membrane. HSP90 also refolds some endogenous cytosolic proteins as part of a foldosome complex containing heat shock cognate 71-kDa protein (HSC70) and the HSC70/HSP90-organizing protein (HOP) linker that anchors HSP90 to HSC70. We accordingly predicted that HSC70 and HOP also function in CTA1 translocation. Inactivation of HSC70 by drug treatment disrupted CTA1 translocation to the cytosol and generated a toxin-resistant phenotype. In contrast, the depletion of HOP did not disrupt CT activity against cultured cells. HSC70 and HSP90 could bind independently to disordered CTA1, even in the absence of HOP. This indicated HSP90 and HSC70 recognize distinct regions of CTA1, which was confirmed by the identification of a YYIYVI-binding motif for HSC70 that spans residues 83-88 of the 192-amino acid CTA1 polypeptide. Refolding of disordered CTA1 occurred in the presence of HSC70 alone, indicating that HSC70 and HSP90 can each independently refold CTA1. Our work suggests a novel translocation mechanism in which sequential interactions with HSP90 and HSC70 drive the N- to C-terminal extraction of CTA1 from the ER.
On optimal design of a lane change controller (2002)

This paper is concerned with automated lane change maneuvers. We first consider the time optimal open loop lane change controller design with nonlinear constraints on the design parameters. Then, we combine the open loop design with a modified closed loop lane following controller so that the closed loop system accomplishes the maneuver as in the open loop case. The performance of the overall controller is demonstrated by simulation examples.