gebhart/patrepeval huggingface dataset:
Data from Distinct Profiles for Mitochondrial t-RNAs and Small Nucleolar RNAs in Locally Invasive and Metastatic Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To gain insight into factors involved in tumor progression and metastasis, we examined the role of noncoding RNAs in the biologic characteristics of colorectal carcinoma, in paired samples of tumor together with normal mucosa from the same colorectal carcinoma patient. The tumor and healthy tissue samples were collected and stored under stringent conditions, thereby minimizing warm ischemic time.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We focused particularly on distinctions among high-stage tumors and tumors with known metastases, performing RNA-Seq analysis that quantifies transcript abundance and identifies novel transcripts.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In comparing 35 colorectal carcinomas, including 9 metastatic tumors (metastases to lymph nodes and lymphatic vessels), with their matched healthy control mucosa, we found a distinct signature of mitochondrial transfer RNAs (MT-tRNA) and small nucleolar RNAs (snoRNA) for metastatic and high-stage colorectal carcinoma. We also found the following: (i) &lt;i&gt;MT-TF&lt;/i&gt; (phenylalanine) and &lt;i&gt;snord12B&lt;/i&gt; expression correlated with a substantial number of miRNAs and mRNAs in 14 colorectal carcinomas examined; (ii) an miRNA signature of oxidative stress, hypoxia, and a shift to glycolytic metabolism in 14 colorectal carcinomas, regardless of grade and stage; and (iii) heterogeneous MT-tRNA/snoRNA fingerprints for 35 pairs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings could potentially assist in more accurate and predictive staging of colorectal carcinoma, including identification of those colorectal carcinomas likely to metastasize. &lt;i&gt;Clin Cancer Res; 22(3); 773–84. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Advances in Cryptology - EUROCRYPT '94: Workshop on the Theory and Application of Cryptographic Techniques, Perugia, Italy, May 9 - 12, 1994. Proceedings (1995)

Visual cryptography.- The size of a share must be large.- A linear construction of perfect secret sharing schemes.- On the dealer's randomness required in secret sharing schemes.- Black box cryptanalysis of hash networks based on multipermutations.- A practical attack against knapsack based hash functions.- The blinding of weak signatures.- Can D.S.A. be improved? - Complexity trade-offs with the digital signature standard -.- Designated confirmer signatures.- Optimal asymmetric encryption.- A multiple-iterated trapdoor for dense compact knapsacks.- On the security of some cryptosystems based on error-correcting codes.- Parallel divertibility of proofs of knowledge.- Methodology for digital money based on general cryptographic tools.- New group signature schemes.- Message recovery for signature schemes based on the discrete logarithm problem.- Threshold-multisignature schemes where suspected forgery implies traceability of adversarial shareholders.- The self-shrinking generator.- Feedback registers based on ramified extensions of the 2-adic numbers.- A general lower bound for the linear complexity of the product of shift-register sequences.- Embedding and probabilistic correlation attacks on clock-controlled shift registers.- Near optimal unconditionally secure authentication.- Authentication codes in plaintext and chosen-content attacks.- Linking information reconciliation and privacy amplification.- A secure and efficient conference key distribution system.- Space requirements for broadcast encryption.- How to break and repair Leighton and Micali's key agreement protocol.- Single-term divisible electronic coins.- Formal requirements for key distribution protocols.- Breaking an efficient anonymous channel.- On Matsui's linear cryptanalysis.- Links between differential and linear cryptanalysis.- On correlation between the order of S-boxes and the strength of DES.- Relationships among nonlinearity criteria.- Efficient exponentiation using precomputation and vector addition chains.- MIMD-Factorisation on hypercubes.- New attacks on all double block length hash functions of hash rate 1, including the Parallel-DM.- New potentially 'weak' keys for DES amd LOK.- Blackmailing using undeniable signatures.- Blind signatures based on the discrete logarithm problem.- Comments on Soviet encryption algorithm.- Linear approximation of block ciphers.- Memory efficient variants of public-key schemes for smart card applications.- A systematic attack on clock controlled cascades.- On A2-codes including arbiter's attacks.- An improvement of Davies' attack on DES.- Q-deformed quantum cryptography.
Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer (2020)

Plasma-derived exosomes of head and neck squamous cell carcinoma (HNSCC) patients carry inhibitory factors mediating immune suppression. Separation of tumor-derived exosomes (TEX) and non-TEX may assist in a better understanding of their respective parental cells. Here, we evaluate the impact of TEX or hematopoietic-derived exosomes on immune suppression. We evaluated apoptosis in CD8+ T cells, conversion of CD4+ T cells to regulatory T cells (T<sub>reg</sub>), and adenosine production by TEX, non-TEX, or total exosomes. Exosome protein cargo was significantly higher in total and CD45(-) exosomes from high stage compared to low stage patients. Furthermore, total and CD45(-) exosomes of high stage patients induced more apoptosis in CD8+ T cells than their low stage counterparts. CD69 suppression, a marker of reduced CD8+ T cell activation, was only mediated by CD45(-) exosomes. All fractions induced T<sub>reg</sub> differentiation, defined by CD39 expression, but only CD45(-) exosomes showed a stage-dependent conversion. CD45(-) exosomes produced higher adenosine concentrations than CD45(+) exosomes, concluding that adenosine production measured in total exosomes mainly derives from TEX. The presented results show significant induction of immune suppression by TEX in HNSCC. This immunosuppressive effect supports the potential role of exosomes as liquid biomarkers for disease stage and level of immune suppression.
Determination of|Vub|from Measurements of the Electron and Neutrino Momenta in Inclusive SemileptonicBDecays (2005)

We present a determination of the Cabibbo-Kobayashi-Maskawa matrix element |Vub| based on the analysis of semileptonic B decays from a sample of 88 x 10(6) Gamma(4S) decays collected with the BABAR detector at the SLAC PEP-II e+e- storage ring. Charmless semileptonic B decays are selected using measurements of the electron energy and the invariant mass squared of the electron-neutrino pair. We obtain |Vub| =(3.95 +/- 0.26(+0.58)(-0.42) +/- 0.25) x 10(-3), where the errors represent experimental uncertainties, heavy quark parameter uncertainties, and theoretical uncertainties, respectively.
Coherent dynamics of continuum and exciton states studied by spectrally resolved fs four-wave mixing (1993)

The coherent dynamics of continuum states and their interplay with excitons at the direct gap of germanium (T=1.8 K) is studied by femtosecond four-wave mixing. In order to unambiguously distinguish between the contribution of continuum states and excitons, we spectrally resolve the diffracted wave as a function of time delay for different excitation photon energies. For excitation many binding energies above the direct gap, the spectra exhibit two clearly separated maxima, one narrow line at the exciton and a much broader contribution of the continuum states. Surprisingly, the continuum contribution persists to longer time delays than the exciton. The experimental results are explained in the framework of the semiconductor Bloch equations.
Optical Fiber Amplifiers and Their Applications. High-Power Polymer Optical Fiber Amplifier. (1997)

In quest of a high-power optical amplifier in the visible, we incorporated organic dyes into polymer optical fibers. Organic dyes were chosen as gain media based on the following features: a large emission cross section, which allows the achievement of high gains in a short length, and a broadband fluorescence spectrum that provides wide tunability. A Rhodamine B-doped POFA, 1 m in length and 0.3mm in core diameter, has exhibited more than 20dB gain at signal wavelengths from 560nm to 600nm when optically pumped at a wavelength of 532nm. Furthermore, we have obtained the optical amplification covering most of the spectral range from 560nm to 650nm. The spectral range in the visible can be continuously covered with the POFAs doped with several selected dyes. The broad spectral coverage demonstrates the versatility of the organic dye-doped POFA.
Flame Photometric Determination of Rubber Solids Deposited on Cords and Fabrics (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlame Photometric Determination of Rubber Solids Deposited on Cords and FabricsH. E. Todd and H. M. TramuttCite this: Anal. Chem. 1954, 26, 7, 1137–1140Publication Date (Print):July 20, 1954Publication History Published online1 May 2002Published inissue 20 July 1954https://pubs.acs.org/doi/10.1021/ac60091a011https://doi.org/10.1021/ac60091a011research-articleACS PublicationsRequest reuse permissionsArticle Views12Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration of color, edge, shape, and texture features for automatic region-based image annotation and retrieval (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Wettability of ceramic surfaces -A wide range control of surface wettability from super hydrophilicity to super hydrophobicity, from static wettability to dynamic wettability (2009)

Surface wettability is dependent to surface energy of the material. Therefore the surface wettability basically reflects its intrinsic surface property and it has been thought that it is hard to be controlled arbitrarily. For example, inorganic materials such like metal oxides usually exhibit relatively hydrophilic property as compared with organic materials. However recent series of studies by our group revealed that photo-induced surface reaction, nanometer scale roughness, nanometer scale physical and chemical heterogeneity affect wettability greatly. This fact clearly shows that the surface wettability of a metal oxide can be controlled from superhydrophilic state to superhydrophobic state. The target of control includes not only static wettability but also dynamic wetttability. Oxide surface with high dynamic hydrophobicity can be obtained by optimizing these factors. Water repellency of developed hydrophobic ceramic surface turned out to be like a polymer surface. The novel technology to control wettability of ceramic surfaces is expected to contribute to various applications.
Tunable SU-8 waveguide grating filter using electrostatic actuation for DWDM optical network (2015)

In this paper we have designed and simulated a novel tunable filter for DWDM optical network utilizing Bragg wavelength shift of SU-8 waveguide grating located on an electrostatically actuated micromachined cantilever beam. The proposed structure consists of a waveguide Bragg grating located on the cantilever beam. When the beam deflects due to an applied electrostatic force, strain is introduced in the beam and hence the grating period changes giving rise to shift in the Bragg wavelength. Since Bragg gratings acts like filter in transmission spectrum we can achieve tunable filter by applying varying voltages to the cantilever beam. For the chosen dimensions The Full Width Half Maximum (FWHM) achievable was 0.89 nm. We have achieved Bragg wavelength shift of 8.7 nm at 1557.58 nm for 19.5 V actuation providing tuning for 12 DWDM channels.
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins (2021)

Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality and also a useful chemical tool in selectively depleting various protein targets. As most efforts focus on cytosolic proteins using PROteolysis TArgeting Chimera (PROTAC), LYsosome TArgeting Chimera (LYTAC) recently emerged as a promising technology to deliver extracellular protein targets to lysosome for degradation through the cation-independent mannose-6-phosphate receptor (CI-M6PR). In this study, we exploited the potential of the asialoglycoprotein receptor (ASGPR), a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. The ligand of ASGPR, triantennary <i>N</i>-acetylgalactosamine (tri-GalNAc), was conjugated to biotin, antibodies, or fragments of antibodies to generate a new class of degraders. We demonstrated that the extracellular protein targets could be successfully internalized and delivered into lysosome for degradation in liver cell lines specifically by these degraders. This work will add a new dimension to TPD with cell type specificity.
Magnetic Stimulation of Motor Cortex and Motor Roots for Painless Evaluation of Central and Proximal Peripheral Motor Pathways Normal Values and Clinical Application in Disorders of the Lumbar Spine (1991)

Magnetic stimulation of the motor cortex, motor roots, and proximal nerve trunks was performed in 46 healthy adults and in 73 consecutive patients with disorders of the lumbar spine. In combination with neurography and F-wave recordings, the fractionated stimulation of the motor pathways allowed calculation of conduction times of the pyramidal tract fibers, of the motor roots (ie, caudal fibers), and of the motor fibers of the lumbosacral plexus. Normal values for motor conduction times to the quadriceps, anterior tibial, and extensor digitorum brevis muscles were established. Patients had clinical and radiologic diagnoses of spinal stenosis (n = 43) and nerve root compression syndromes (n = 30). Motor conduction times to lower limb muscles were significantly delayed (above mean normal value +/- 2 x SD) in 65% of the patients with spinal stenosis and 50% of the patients with nerve root compression syndromes. Conduction slowing could be localized within the motor root and caudal fiber segment of the motor pathways in 80% of the patients in whom F-waves could be recorded. This method can be used to verify, quantify, and locate lesions of the motor pathways in conditions such as compression of the spinal cord, the caudal fibers (spinal stenosis), or the motor root passing through the intervertebral canal.
Incentive Design for Efficient Federated Learning in Mobile Networks: A Contract Theory Approach (2019)

The following topics are dealt with: MIMO communication; error statistics; 5G mobile communication; wireless channels; telecommunication power management; cellular radio; probability; interference suppression; Internet of Things; radio spectrum management.
Exploring the trajectory curve of long-term musculoskeletal post-COVID pain symptoms in hospitalized COVID-19 survivors: a multicenter study (2022)

This multicenter cohort study investigated the prevalence of musculoskeletal post-COVID pain during the first year after the infection with mosaic plots and an exponential bar plot model and its associated risk factors. Patients hospitalized because of COVID-19 in 5 hospitals of Madrid (Spain) were scheduled for a telephone interview at 2 follow-up periods after hospitalization for collecting data about musculoskeletal post-COVID pain. Hospitalization and clinical data were collected from hospital medical records. From 2000 patients initially recruited, 1593 (44.6% women, age: 61 ± 15 years) were assessed at T0 (hospital admission), T1 (mean: 8.0 ± 1.5 months after discharge), and T2 (mean: 13.2 ± 1.5 months after discharge). The prevalence of musculoskeletal pain (myalgia) was 30.3% (n = 483) at T0, increased to 43.4% (n = 692) at T1, and decreased to 37.8% (n = 603) at T2. The trajectory curve revealed a decreasing prevalence trend of musculoskeletal post-COVID pain the following years after hospitalization. According to the presence of pre-existing pain symptoms, the prevalence of new-onset post-COVID pain was 75.9%. Female sex (odds ratio [OR] 1.593, 95% confidence interval [CI] 1.148-2.211), history of musculoskeletal pain (OR 1.591, 95% CI 1.211-2.07), the presence of myalgia (OR 1.371, 95% CI 1.032-1.821) or headache (OR 2.278, 95% CI 1.622-3.199) at hospitalization, the days of hospitalization (OR 1.013, 95% CI 1.000-1.025), and the presence of post-COVID pain at T1 (OR 11.02, 95% CI 8.493-14.305) were factors associated with musculoskeletal post-COVID pain 1 year after hospitalization. In conclusion, musculoskeletal post-COVID pain remains highly prevalent 1 year after hospitalization. Female sex, previous history of pain symptoms, pain symptoms at onset, and days at hospital were factors associated with musculoskeletal post-COVID pain 1 year after hospitalization.
Analysis of microbiota-host communication mediated by butyrate in Atlantic salmon (2023)

Butyrate is a microbiota-produced metabolite, sensed by host short-chain fatty acid receptors FFAR2 (Gpr43), FFAR3 (Gpr41), HCAR2 (Gpr109A), and Histone deacetylase (HDAC) that promotes microbiota-host crosstalk. Butyrate influences energy uptake, developmental and immune response in mammals. This microbial metabolite is produced by around 79 anaerobic genera present in the mammalian gut, yet little is known about the role of butyrate in the host-microbiota interaction in salmonid fish. To further our knowledge of this interaction, we analyzed the intestinal microbiota and genome of Atlantic salmon (<i>Salmo salar</i>), searching for butyrate-producing genera and host butyrate receptors. We identified Firmicutes, Proteobacteria, and Actinobacteria as the main butyrate-producing bacteria in the salmon gut microbiota. In the Atlantic salmon genome, we identified an expansion of genes orthologous to FFAR2 and HCAR2 receptors, and class I and IIa HDACs that are sensitive to butyrate. In addition, we determined the expression levels of orthologous of HCAR2 in the gut, spleen, and head-kidney, and FFAR2 in RTgutGC cells. The effect of butyrate on the Atlantic salmon immune response was evaluated by analyzing the pro and anti-inflammatory cytokines response in vitro in SHK-1 cells by RT-qPCR. Butyrate decreased the expression of the pro-inflammatory cytokine IL-1β and increased anti-inflammatory IL-10 and TGF-β cytokines. Butyrate also reduced the expression of interferon-alpha, Mx, and PKR, and decreased the viral load at a higher concentration (4 mM) in cells treated with this molecule before the infection with Infectious Pancreatic Necrosis Virus (IPNV) by mechanisms independent of FFAR2, FFAR3 and HCAR2 expression that probably inhibit HDAC. Moreover, butyrate modified phosphorylation of cytoplasmic proteins in RTgutGC cells. Our data allow us to infer that Atlantic salmon have the ability to sense butyrate produced by their gut microbiota via different specific targets, through which butyrate modulates the immune response of pro and anti-inflammatory cytokines and the antiviral response.
Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals (2014)

The oral bioavailability of many lipophilic bioactive agents (pharmaceuticals and nutraceuticals) is limited due to various physicochemical and physiological processes: poor release from food or drug matrices; low solubility in gastrointestinal fluids; metabolism or chemical transformation within the gastrointestinal tract; low epithelium cell permeability. The bioavailability of these agents can be improved by specifically designing food matrices that control their release, solubilization, transport, metabolism, and absorption within the gastrointestinal tract. This article discusses the impact of food composition and structure on oral bioavailability, and how this knowledge can be used to design excipient foods for improving the oral bioavailability of lipophilic bioactives. Excipient foods contain ingredients or structures that may have no bioactivity themselves, but that are able to promote the bioactivity of co-ingested bioactives. These bioactives may be lipophilic drugs in pharmaceutical preparations (such as capsules, pills, or syrups) or nutraceuticals present within food matrices (such as natural or processed foods and beverages).
Distributed management of flexible times schedules (2007)

We consider the problem of managing schedules in an uncertain, distributed environment. We assume a team of collaborative agents, each responsible for executing a portion of a globally pre-established schedule, but none possessing a global view of either the problem or solution. The goal is to maximize the joint quality obtained from the activities executed by all agents, given that, during execution, unexpected events will force changes to some prescribed activities and reduce the utility of executing others. We describe an agent architecture for solving this problem that couples two basic mechanisms: (1) a "flexible times" representation of the agent's schedule (using a Simple Temporal Network) and (2) an incremental rescheduling procedure. The former hedges against temporal uncertainty by allowing execution to proceed from a set of feasible solutions, and the latter acts to revise the agent's schedule when execution is forced outside of this set of solutions or when execution events reduce the expected value of this feasible solution set. Basic coordination with other agents is achieved simply by communicating schedule changes to those agents with inter-dependent activities. Then, as time permits, the core local problem solving infra-structure is used to drive an inter-agent option generation and query process, aimed at identifying opportunities for solution improvement through joint change. Using a simulator to model the environment, we compare the performance of our multiagent system with that of an expected optimal (but non-scalable) centralized MDP solver.