gebhart/patrepeval huggingface dataset:
Renal Translocation Carcinomas (2008)

We report clinicopathologic features of a large series of renal translocation carcinomas from a multicentric study. Diagnosis was performed by cytogenetic examination of fresh material and/or by immunochemistry with antibodies directed against the C-terminal part of transcription factor E3 (TFE3) and native transcription factor EB (TFEB) proteins. Clinical data, follow-up, and histologic features were assessed. Antibodies against CK7, CD10, vimentin, epithelial membrane antigen, AE1-AE3, E-cadherin, alpha-methylacyl-coenzyme A racemase, melan A, and HMB45 were tested on tissue microarrays. Whole-genome microarray expression profiling was performed on 4 tumors. Twenty-nine cases were diagnosed as TFE3 and 2 as TFEB renal translocation carcinomas, including 13 males and 18 females, mean age 24.6 years. Two patients had a previous history of chemotherapy and 1 had a history of renal failure. Mean size of the tumor was 6.9 cm. Thirteen cases were > or = pT3 stage. Twelve cases were N+ or M+. Mean follow-up was 29.5 months. Three patients presented metastases and 5 have died. Mixed papillary and nested patterns with clear and/or eosinophilic cells represented the most consistent histologic appearance, with common foci of calcifications regardless of the type of translocation. Using a 30 mn incubation at room temperature, TFE3 immunostainings were positive in only 82% of our TFE3 translocation carcinomas. Both TFE3 and TFEB renal translocation carcinomas expressed CD10 and alpha-methylacyl-coenzyme A racemase in all cases. An expression of E-cadherin was observed in two-third of cases. Cytokeratins were expressed in less than one-third of cases. Melanocytic markers were expressed at least weakly in all cases except two. Unsupervised clustering on the basis of the gene expression profiling indicated a distinct subgroup of tumors. TRIM 63 glutathione S-transferase A1 and alanyl aminopeptidase are the main differentially expressed genes for this group of tumors. Our results suggest that these differentially expressed genes may serve as novel diagnostic or prognostic markers.
Autometallographic Silver Amplification of Colloidal Gold (1993)

Measures required to maximize the sensitivity and specificity of autometallographic (AMG) silver enlargement of colloidal gold particles are described. The silver amplification technique is called AMG because metal is what triggers the magnification process. As AMG has a multitude of applications apart from its use in immunohistochernistry, it is important that silver techniques based on Liesegang's original physical developer have a name that is both logical and easy to remember to facilitate the spread of technical AMG improvements to come.The chemical process that is believed to take place during AMG is described and illustrated, and the two technically different ways ofutilizing AMG arediscussed. Although other modifications of Liesegang's original AMG developer have been devised in laboratories all over the world and could be just as valuable, we off offer five protocols we believe optimize results of colloidal gold AMG. (The J Histotechnol 16:201, 1993)
Evoked and Spontaneous Electromyography to Evaluate Lumbosacral Pedicle Screw Placement (1996)

Measuring the electrically evoked electromyography threshold of stimulation helps to assess pedicle screw placement. Mechanically evoked electromyography indicates intraoperative nerve root displacement. Postoperative radiculopathy correlated with pedicle wall breakthrough, but did not occur in every case.
Novel geometries to reduce the spectroscopic degradation associated with the drift-field of radiation detectors: a monte carlo simulation study for xenon-filled counters (2005)

Many radiation detectors make use of an electric field to drift the electrons that result from the absorption of the incoming radiation. Previous simulation studies have demonstrated that, in gas detectors, the fact that charged particles exchange energy with the field leads to the degradation of the system's spectroscopic capabilities. New geometries based on opposite electric fields may reduce this effect, as somehow, a compensation of the energy that is gained/lost from/to the field is achieved. In this communication, the performance of several xenon-based radiation detectors with these novel geometries was assessed using the Monte Carlo code PENELOPE. At energies of about 100 and 200 keV, and considering 1, 2, 4 and 8 regions with opposite electric fields, the simulation results indicate that the degradation associated with the drift electric field can be reduced and that this achievement is more noticeable for higher photon energies. In what concerns the absorption of 200 keV photons, when considering a detector with 8 regions, rather than one with a standard geometry, it has been observed a decrease of 82% in the FWHM of the gaussian curve describing the peak that corresponds to full energy absorption events.
Polarization independent fast BOTDA based on pump frequency modulation and cyclic coding (2018)

We propose and experimentally demonstrate a scheme of polarization independent fast Brillouin optical time domain analysis (F-BOTDA) based on pump frequency modulation and cyclic coding. The Brillouin gain spectrum (BGS) is reconstructed by fast scanning frequency of the pump using an arbitrary waveform generator (AWG). To realize long range distributed dynamic strain sensing, polarization diversity technique and cyclic coding are employed to eliminate polarization fading and enhance the signal-to-noise ratio (SNR). Based on this configuration, the need of trace averaging is avoided, sensing speed of 440 Hz is achieved over ~2 km single mode fiber with 50 scanning frequencies and a spatial resolution of 1.5 m. Vibration events up to 40 Hz are successfully identified.
The effect of harmonic distortion in the use of vibratory surface sources (1970)

Abstract Harmonic distortion apparently arising from nonlinear processes, especially coupling of the vibrator to the ground, has often been observed in land seismic operations utilizing a frequency-modulated mechanical vibrator as a surface source. The effect of harmonic distortion is to add a long oscillatory tail to the correlogram of a single sweep for the case in which the sweep frequency decreases with time. For up-sweeps the distortion effect appears as a forerunner. It is shown analytically that for kth harmonic distortion, the zero-to-peak amplitude of the distortion tail (or forerunner) relative to the autocorrelation peak when the seismogram is crosscorrelated with the undistorted outgoing signal is given approximately by 1/(k - 1)TW times the amplitude ratio of harmonic to fundamental. W is the frequency range of the fundamental sweep and T is its length. Some examples computed by crosscorrelating a fundamental sweep (generated artificially) with its harmonic components are shown to demonstrate the effect of harmonic distortion. Some results on harmonic distortion observed in field seismograms recorded in the Val Verde basin of West Texas are presented. Second harmonic distortion of the order of 30 to 100 percent of the fundamental was observed.
Generative Joint Source-Channel Coding for Semantic Image Transmission (2023)

Recent works have shown that joint source-channel coding (JSCC) schemes using deep neural networks (DNNs), called DeepJSCC, provide promising results in wireless image transmission. However, these methods mostly focus on the distortion of the reconstructed signals with respect to the input image, rather than their perception by humans. However, focusing on traditional distortion metrics alone does not necessarily result in high perceptual quality, especially in extreme physical conditions, such as very low bandwidth compression ratio (BCR) and low signal-to-noise ratio (SNR) regimes. In this work, we propose two novel JSCC schemes that leverage the perceptual quality of deep generative models (DGMs) for wireless image transmission, namely InverseJSCC and GenerativeJSCC. While the former is an inverse problem approach to DeepJSCC, the latter is an end-to-end optimized JSCC scheme. In both, we optimize a weighted sum of mean squared error (MSE) and learned perceptual image patch similarity (LPIPS) losses, which capture more semantic similarities than other distortion metrics. InverseJSCC performs denoising on the distorted reconstructions of a DeepJSCC model by solving an inverse optimization problem using the pre-trained style-based generative adversarial network (StyleGAN). Our simulation results show that InverseJSCC significantly improves the state-of-the-art DeepJSCC in terms of perceptual quality in edge cases. In GenerativeJSCC, we carry out end-to-end training of an encoder and a StyleGAN-based decoder, and show that GenerativeJSCC significantly outperforms DeepJSCC both in terms of distortion and perceptual quality.
Can Defect Prediction Be Useful for Coarse-Level Tasks of Software Testing? (2020)

It is popular to use software defect prediction (SDP) techniques to predict bugs in software in the past 20 years. Before conducting software testing (ST), the result of SDP assists on resource allocation for ST. However, DP usually works on fine-level tasks (or white-box testing) instead of coarse-level tasks (or black-box testing). Before ST or without historical execution information, it is difficult to get resource allocated properly. Therefore, a SDP-based approach, named DPAHM, is proposed to assist on arranging resource for coarse-level tasks. The method combines analytic hierarchy process (AHP) and variant incidence matrix. Besides, we apply the proposed DPAHM into a proprietary software, named MC. Besides, we conduct an up-to-down structure, including three layers for MC. Additionally, the performance measure of each layer is calculated based on the SDP result. Therefore, the resource allocation strategy for coarse-level tasks is gained according to the prediction result. The experiment indicates our proposed method is effective for resource allocation of coarse-level tasks before executing ST.
Building Resilient Urban Communities (2006)

Many societies in the world live with different types of risks and the threat of disasters has always presented a major challenge to devise ways to achieve sustainable development by reducing patterns of vulnerability. Disaster reduction is therefore crucial and must have a place in national policies in order to create favourable conditions for effective and efficient hazard mitigation at various levels. This can help in increasing the resilience among communities at risk by enabling them to withstand shocks, cope with emergencies as they bounce back from the impact and adapt in new ways to cope with future threats. The aim of this paper is to explore the concept of resilience in general and what this means before, during, and after disaster impact. Case studies are cited to indicate how resilience operates or fails to occur and why. The study defines how resilience can be developed to create sustainable systems and structures that focus on robustness, redundancy, resourcefulness and rapidity.
PCQ: Preferred Comfort Questionnaires for product design (2020)

We expect that the PCQ list can be used as a useful instrument to help researchers in selecting questionnaires for comfort research in product design.
Single phase AC power load profile emulator (2008)

This paper deals with the realization and design of a consumption profile emulator intended for the validation of different element energy models of a stand-alone wind and photovoltaic system, associated with electrochemical energy storage [1]. The emulator is designed to vary active power but in the near future it will also be used to load simulation with reactive power. Energy models are then inserted in a sizing optimization algorithm in order to minimize the Global Energy Requirement (GER) of the whole system [2]. Afterwards, we will focus on the emulator power part dimensioning and then its modelling in view of the stand-alone system controlled by an active power reference. Moreover, the digital profile generator is described. The impact on the DC bus capacitor current, caused by the frequency difference between the grid and the inverter, has also been tackled. Finally, experimental results are shown.
The Functional Basis of Mycophenolic Acid Resistance in Candida albicans IMP Dehydrogenase (2005)

Candida albicans is an important fungal pathogen of immunocompromised patients. In cell culture, C. albicans is sensitive to mycophenolic acid (MPA) and mizoribine, both natural product inhibitors of IMP dehydrogenase (IMPDH). These drugs have opposing interactions with the enzyme. MPA prevents formation of the closed enzyme conformation by binding to the same site as a mobile flap. In contrast, mizoribine monophosphate, the active metabolite of mizoribine, induces the closed conformation. Here, we report the characterization of IMPDH from wild-type and MPA-resistant strains of C. albicans. The wild-type enzyme displays significant differences from human IMPDHs, suggesting that selective inhibitors that could be novel antifungal agents may be developed. IMPDH from the MPA-resistant strain contains a single substitution (A251T) that is far from the MPA-binding site. The A251T variant was 4-fold less sensitive to MPA as expected. This substitution did not affect the k(cat) value, but did decrease the K(m) values for both substrates, so the mutant enzyme is more catalytically efficient as measured by the value of k(cat)/K(m). These simple criteria suggest that the A251T variant would be the evolutionarily superior enzyme. However, the A251T substitution caused the enzyme to be 40-fold more sensitive to mizoribine monophosphate. This result suggests that A251T stabilizes the closed conformation, and this hypothesis is supported by further inhibitor analysis. Likewise, the MPA-resistant strain was more sensitive to mizoribine in cell culture. These observations illustrate the evolutionary challenge posed by the gauntlet of chemical warfare at the microbial level.
Моделирование движения материальных потоков в центробежно-шнековом смесителе (2015)

The mathematical process of the disperse material mixing with the use of the correlation analysis on the basis of which the numerical values of the centrifugal-auger mixer smoothing ability are received is presented in the article. The mathematical model realization showed that the organization of the advancing streams in the working camera of the mixer has a great influence on the uniformity of material streams in the mixer.
Heat evacuation from active Raman media using frequency-selective dissipative coupling (2021)

We propose to use frequency-selective dissipative coupling to reduce the heat generated by coherent anti-Stokes Raman scattering (CARS) reversed cycles in active Raman media with phase mismatch. This is accomplished using a coupled-waveguide structure, which includes the active Raman waveguide (RW), where the Stokes signal undergoes amplification via stimulated Stokes Raman scattering (SSRS), and a dissipative waveguide (DW), which is tuned to the anti-Stokes wavelength so as to evacuate the corresponding anti-Stokes photons from the RW by coupling. The DW introduces optical loss that partially offsets the growth of the anti-Stokes signal in the RW and hence suppress the reversed CARS cycles that would otherwise result into heat generation in the RW. It is shown that the frequency-selective dissipative coupling provided by the DW can reduce the heat in active Raman media by a very factor of up to 5 when the CARS phase mismatch is compensated for by the optimum level of coupling between the RW and the DW.
Frequency Offset Estimation in 3G LTE (2010)

3G Long Term Evolution (LTE) technology aims at addressing the increasing demand for mobile multimedia services in high user density areas while maintaining good performance in extreme channel conditions such as high mobility of High Speed Trains. This paper focuses on the latter aspect and compares different algorithms for the uplink frequency offset estimation in LTE Base Stations (eNodeB). A frequency-domain maximum-likelihood based solution is proposed, taking profit of the available interference-free OFDM symbols de-mapped (or de-multiplexed) at the output of the FFT of an OFDMA multi-user receiver. It is shown to outperform the state-of-the-art CP correlation approach on both link-level performance and complexity aspects.
Comparison of numerical methods and combustion models for LES of a ramjet (2009)

Ramjets are very sensitive to instabilities and their numerical predictions can only be addressed adequately by Large Eddy Simulation (LES). With this technique, solvers can be implicit or explicit and handle structured, unstructured or hybrid meshes, etc. Turbulence and combustion models are other sources of differences. The impact of these options is here investigated for the ONERA ramjet burner. To do so, two LES codes developed by ONERA and CERFACS compute one stable operating condition. Preliminary LES results of the two codes underline the overall robustness of LES. Mean flow features at the various critical sections are reasonably well predicted by both codes. Disagreement mainly appear in the chamber where combustion positions differ pointing to the importance of the combustion and subgrid mixing models. The two LES produce different energy containing motions. With CEDRE, a low frequency dominates while AVBP produces different ranges of low frequencies that can be linked with acoustic modes of the configuration.
Competing Annulene and Radialene Structures in a Single Anti-Aromatic Molecule Studied by High-Resolution Atomic Force Microscopy (2017)

According to Hückel theory, an anti-aromatic molecule possessing (4n)π-electrons becomes unstable. Although the stabilization has been demonstrated by radialene-type structures-fusing aromatic rings to anti-aromatic rings-in solution, such molecules have never been studied at a single molecular level. Here, we synthesize a cyclobutadiene derivative, dibenzo[b,h]biphenylene, by an on-surface intramolecular reaction. With a combination of high-resolution atomic force microscopy and density functional theory calculations, we found that a radialene structure significantly reduces the anti-aromaticity of the cyclobutadiene core, extracting π-electrons, while the small four-membered cyclic structure keeps a high density of the total charge.
L'analyse de la variabilité gestuelle peut-elle devenir un moyen de développer l'activité des professionnels et de repenser leur formation? (2016)

International audience
The Need for Software Migration Systems (2006)

Software translation activities tend to decrease in efficiency as the number of supported source and target languages increase. This paper presents an improved approach by organizing translators into software migration systems. It also analyzes the impact of this approach on the efficiency in the dynamics of such systems.
Numerical Simulation of High Power r.f. Sources (1983)

In high power microwave tubes the efficient conversion of kinetic electron beam energy to R.F. in a narrow frequency band involves complicated nonlinear electron dynamics and may involve the spontaneous generation of waves at other frequencies. This paper describes the adaptation of an electromagnetic 2D-3V particle-in-cell code MASK to the simulation of such high power R.F. sources. In situations where the R.F. interaction results in the reflection of beam particles, or where there is the excitation of multiple models internal to the microwave device, simulations are a new tool that permit a representation of the physical processes. In addition, they are capable of modeling the transient behavior and not just steady state operation. One of the applications of MASK at SLAC is to aid in the design of a new 150 MW Klystron at 2.85 GHz. This work is currently in progress and the approach to it is outlined. Preliminary results have been obtained for a model two cavity problem and are presented. These results illustrate the complicated dynamics in the nonlinear regime including the presence of reflected particles and harmonic generation. The code has also been run in the linear regime where good agreement has been found with smallmore » signal theory.« less
Acid/Base Switching of the Tautomerism and Conformation of a Dioxoporphyrin for Integrated Binary Subtraction (2014)

Compared with most of the reported logic devices based on the supramolecular approach, systems based on individual molecules can avoid challenging construction requirements. Herein, a novel dioxoporphyrin DPH22 was synthesized and two of its tautomers were characterized by single-crystal X-ray diffraction studies. Compound DPH22 exhibits multichannel controllable stepwise tautomerization, protonation, and deprotonation processes through interactions with H(+) and F(-) ions. By using the addition of H(+) and F(-) ions as inputs and UV/Vis absorption values at λ=412, 510, 562, and 603 nm as outputs, the controlled tautomerism of DPH22 has been successfully used for the construction of an integrated molecular level half-subtractor and comparator. In addition, this acid/base-switched tautomerism is reversible, thus endowing the system with ease of reset and recycling; consequently, there is no need to modulate complicated intermolecular interactions and electron-/charge-transfer processes.
“On-The-Spot” Arresting of Chondroitin Sulphate Proteoglycans: Implications for Ovarian Adenocarcinoma Recognition and Intervention (2016)

Ovarian Cancer (OC) is one of the leading causes of cancer-associated death among women. The underlying biochemical cause of OC proliferation is usually attributed to the over-expression of Chondroitin Sulphate Proteoglycans (CSPGs) wherein the CS-E subgroup plays a major role in tumor cell proliferation by over-expressing vascular endothelial growth factor (VEGF). We hereby hypothesize that by targeting the OC extracellular matrix using a CS-E-specific antibody, GD3G7, we could provide spatial delivery of crosslinkers and anti-VEGF agents to firstly induce in vivo crosslinking and complexation (arresting) of CS-E into a "biogel mass" for efficient and effective detection, detachment and reduction of tumorous tissue, and secondly inhibit angiogenesis in OC. It is further proposed that the antibody-assisted targeted delivery of CS-E crosslinkers can bind to highly anionic CS-E to form a polyelectrolyte complex to inhibit the formation of ovarian tumor spheroids that are responsible for spheroid-induced mesothelial clearance and progression of OC. The hypothesis also describes the potential in vivo "On-The-Spot" CSPG crosslinkers such as sodium trimetaphosphate (physical crosslinker), 1,12-diaminododecane (chemical crosslinker), poly(ethylene glycol) diglycidyl ether (synthetic polymer), and chitosan (natural polyelectrolyte-forming agent). In conclusion, this hypothesis proposes in vivo spatial crosslinking of CSPGs as a potential theranostic intervention strategy for OC-a first in the field of cancer research.
The Current Status of Utilization of Palliative Care Units in Korea: 6 Month Results of 2009 Korean Terminal Cancer Patient Information System (2010)

Dong Wook Shin, M.D., M.B.A.*§, Jin Young Choi, Ph.D.*, Byung Ho Nam, Ph.D.†, Won Seok Seo, M.S.†, Hyo Young Kim, B.S.*, Eun Joo Hwang, B.S.*, Jina Kang, M.E.A.*, So Hee Kim, M.S.†, Yang Hyuck Kim, M.S.† and Eun Cheol Park, M.D., Ph.D.‡. J Hosp Palliat Care 2010;13:181-9. https://doi.org/10.14475/kjhpc.2010.13.3.181