gebhart/patrepeval huggingface dataset:
Sequential analysis of chemically induced hepatoma development in rats by two dimensional electrophoresis. (1986)

Using the Solt-Farber hepatocarcinogenesis model, a large population of preneoplastic and neoplastic nodules were induced in male Fischer 344 rats. Total cellular polypeptides from normal liver and individual preneoplastic and neoplastic nodules were analyzed for both qualitative and quantitative changes using computer assisted high resolution two-dimensional electrophoresis. Approximately 800-1000 cytosolic and 1200-1400 membrane associated polypeptides were readily separated and detected using an ultrasensitive silver stain. The polypeptide patterns were remarkably similar for each tissue and only four qualitative polypeptide differences were noted. One cytosolic polypeptide, 6.8/57 (designated pl/Mr X 10(-3), and three membrane associated polypeptides, 6.25/41, 6.75/24, and 6.05/21, were expressed in both preneoplastic and neoplastic nodules but not in normal liver. No qualitative polypeptide differences were detected among the individual preneoplastic or individual neoplastic nodules or between preneoplastic and neoplastic nodules. Numerous quantitative changes in both known markers for hepatocarcinogenesis and in as yet unidentified polypeptides were noted. In particular, the Ya subunit of glutathione S-transferase B, the Yb subunit of glutathione S-transferase A, as well as the three isoelectric point variants of the Yp subunit of glutathione S-transferase P were increased 2-, 4-, and 7-fold, respectively, in preneoplastic and neoplastic nodules. Whereas DT-diaphorase was increased 2-3-fold in hyperplastic nodules as compared to normal liver, no differences in the expression of albumin were noted. Although no differences were observed in the expression of aldehyde dehydrogenase in preneoplastic and neoplastic nodules, polypeptide b (6.9/54) was shifted slightly toward the basic region in normal liver. alpha-Fetoprotein was not detected in either preneoplastic or neoplastic nodules. In addition to these changes in known markers, comparison of 500-800 cytosolic and 750-1000 membrane associated polypeptides showed that roughly 4-10% of the polypeptides were undergoing quantitative changes of at least 4-fold during these stages of hepatocarcinogenesis. Thirty (10 cytosolic and 20 membrane) polypeptides were significantly down-regulated while 22 (7 cytosolic and 15 membrane) polypeptides were up-regulated in both preneoplastic and neoplastic nodules. In all cases the direction and magnitude of change were the same in both preneoplastic and neoplastic nodules with the exception of three polypeptides.(ABSTRACT TRUNCATED AT 400 WORDS)
Effect of Marathon Running on Hematologic and Biochemical Laboratory Parameters, Including Cardiac Markers (2002)

Participants in marathon races may require medical attention and the performance of laboratory assays. We report the changes in basic biochemical parameters, cardiac markers, CBC counts, and WBC differentials observed in participants in a marathon before, within 4 hours, and 24 hours after a race. The concentrations of glucose, total protein, albumin, uric acid, calcium, phosphorus, serum urea nitrogen, creatinine, bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total creatine kinase, creatine kinase-MB, myoglobin, and the anion gap were increased after the race, consistent with the effects of exertional rhabdomyolysis and hemolysis. The increase in WBC counts was due mainly to neutrophilia and monocytosis, with a relative decrease in circulating lymphocytes, consistent with an inflammatory reaction to tissue injury. A significant percentage of laboratory results were outside the standard reference ranges, indicating that modified reference ranges derivedfrom marathon runners might be more appropriatefor this population. We provide a table of modified reference ranges (or expected ranges) for basic biochemical, cardiac, and hematologic laboratory parameters for marathon runners.
Monolithic Continuous-Wave Optical Parametric Ring Oscillator in Periodically Poled Lithium Niobate (2010)

We report a monolithic singly-resonant cw optical parametric oscillator (OPO) in periodically poled lithium niobate. The threshold is 1.0 W and the OPO delivers up to 0.98 W signal tunable between 1750 and 1950 nm.
Development of porous polypropylene blends with NA11 particles and glass hollow spheres by biaxial stretching for electret applications (2006)

In the present work, the development of cellular films by stretching isotactic polypropylene (i-PP) filled with NA11 (2,2'-methylene-bis-(4,6-di-tert-butylphenyl)-phosphate) particles and hollow glass spheres is reported. Morphology, electret properties and piezoelectric activity are investigated. An enhancement of the charge storage stability for the cellular films is due to the formation of cavities, which retard the drift of charges through the volume of the film. Furthermore, the cellular stretched i-PP films with hollow glass spheres were made piezoelectric by suitable corona poling method. Films were stretched to draw ratios of 3.5:3.5 (medium stretched) and selected samples were drawn to ratios of 5:5 (highly stretched). The applied draw ratio was found to directly influence the cavity formations and by this the electret and piezoelectric properties. Excellent electret properties were obtained in the case of highly stretched i-PP films containing 10 wt% of NA11, known as a nucleating agent additive for i-PP. Additionally, piezoelectric activity (d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> =179 pC/N) was observed in these films. i-PP films with glass spheres showed piezoelectric coefficients between 17 and 170 pC/N, depending on glass sphere size and concentration as well as on draw ratio
The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage (2015)

The non-receptor tyrosine kinase c-Abl is activated in response to DNA damage and induces p73-dependent apoptosis. Here, we investigated c-Abl regulation of the homeodomain-interacting protein kinase 2 (HIPK2), an important regulator of p53-dependent apoptosis. c-Abl phosphorylated HIPK2 at several sites, and phosphorylation by c-Abl protected HIPK2 from degradation mediated by the ubiquitin E3 ligase Siah-1. c-Abl and HIPK2 synergized in activating p53 on apoptotic promoters in a reporter assay, and c-Abl was required for endogenous HIPK2 accumulation and phosphorylation of p53 at Ser(46) in response to DNA damage by γ- and UV radiation. Accumulation of HIPK2 in nuclear speckles and association with promyelocytic leukemia protein (PML) in response to DNA damage were also dependent on c-Abl activity. At high cell density, the Hippo pathway inhibits DNA damage-induced c-Abl activation. Under this condition, DNA damage-induced HIPK2 accumulation, phosphorylation of p53 at Ser(46), and apoptosis were attenuated. These data demonstrate a new mechanism for the induction of DNA damage-induced apoptosis by c-Abl and illustrate network interactions between serine/threonine and tyrosine kinases that dictate cell fate.
Saponin and sapogenol. XIII. Structures of three soybean saponins: Soyasaponin I, soyasaponin II, and soyasaponin III. (1976)

Soyasaponin I (major), II and III, all of which possess soyasapogenol B (2) as the common aglycone, have been isolated from the MeOH extractive of soybean (Glycine max MERRILL, Leguminosae). On the basis of chemical and physicochemical evidence, the structure of soyasaponin I has been elucidated to be 3-O-[α-L-rhamnopyranosyl (1→2)-β-D-galactopyranosyl (1→2)-β-D-glucuronopyranosyl]-soyasapogenol B (7) and the structures of soyasaponin II and III to be 3-O-[α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl (1→2)-β-D-glucuronopyranosyl]-soyasapogenol B (8) and 3-O-[β-D-galactopyranosyl (1→2)-β-D-glucuronopyranosyl]-soyasapogenol B (9), respectively.
Least Probable Disagreement Region for Active Learning (2021)

Active learning strategy to query unlabeled samples nearer the estimated decision boundary at each step has been known to be effective when the distance from the sample data to the decision boundary can be explicitly evaluated; however, in numerous cases in machine learning, especially when it involves deep learning, conventional distance such as the lp from sample to decision boundary is not readily measurable. This paper defines a theoretical distance of unlabeled sample to the decision boundary as the least probable disagreement region (LPDR) containing the unlabeled sample, and it discusses how this theoretical distance can be empirically evaluated with a lower order of time complexity. Monte Carlo sampling of the hypothesis is performed in approximating the theoretically defined distance. Experimental results on various datasets show that the proposed algorithm consistently outperforms all other high performing uncertainty based active learning algorithms and leads to state-of-the-art active learning performance on CIFAR10, CIFAR100, Tiny ImageNet and Food101 datasets. Only the proposed algorithm outperforms random sampling on CIFAR100 dataset using K-CNN while all other algorithms fail to do so.
Mathematical model of QoS-aware multicast transmission via periodic reservations (2016)

The increasing amount of audio and video data transmitted over Wi-Fi networks raises a problem of parametrized Quality of Service (QoS) provisioning, which is challenging even for point-to-point transmission. QoS provisioning is much more complicated when a wireless access point (AP) streams IPTV or another multimedia flow to a group of receiving stations. This scenario is a typical use case for IEEE 802.11aa, a recently approved amendment to the Wi-Fi standard. To improve performance of multicast transmission, the amendment defines several approaches. In the paper, we study their efficiency in the case, when deterministic channel access with periodic reservations is used to improve reliability of multicast transmission. For that we develop a mathematical model and use the model both to compare efficiency of the approaches and to select the best parameters for channel reservation <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Single-phase AC-AC converters using power MOSFETs (1988)

The authors analyze the performance of a single-phase AC-AC converter with particular emphasis on the output harmonic content and input voltage utilization. A complete power circuit that makes use of power MOSFETs is given. An analysis of the output waveform shows that its harmonic content is very low. It is also found that the ratio of the switching frequency to the modulating triangular wave, has negligible effect on the harmonic content. Hence, the ratio can be chosen at nominal value of 4 and it is mainly used to control the amplitude of the fundamental component in the output. The only disadvantage of the single-phase AC-AC converter is that the amplitudes of certain harmonic frequencies become abnormally high.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunotherapy for malignancies and viral infections (2000)

Immunotherapy approaches have been increasingly used to treat relapsed malignancy and viral infections after solid organ or hematopoietic stem cell transplant. Adoptive cellular immunotherapy with donor T lymphocytes or cytotoxic T cells has proven effective therapy for Epstein-Barr virus lymphoma and some relapsed leukemias after allogeneic stem cell transplantation, and the use of autologous or haploidentical Epstein-Barr virus–specific cytotoxic T lymphocyte lines is being explored after solid organ transplant. More recently, the humanized CD20 antibody rituximab has shown efficacy in the therapy of post-transplant lymphoma. Other antibodies are in trials to treat relapsed malignancy and other viral infections.
A Mixed Signal (Analog-Digital) Integrator Design (2012)

Presented is a design of a mixed signal integrator, consisting of a traditional analog integrator (op-amp with capacitor in feedback) augmented with comparators, logic, counter registers, and a precharged capacitor that can be switched into, and out of, the input of the analog integrator. This device integrates with analog, but stores results in analog and digital. Whenever an analog integrator voltage equals or exceeds a threshold voltage, an amount of charge equivalent to the threshold voltage is cleared from the feedback capacitor of the analog integrator, and the counter register is incremented or decremented accordingly. With the threshold voltage representing one in a counting system, these actions convert the integrator contents to ±1. At any instant, the counter register holds the integer portion of the integral, and the analog integrator holds any fractional portion, permitting the integral to be internally stored as a real number. The mixed signal integrator accumulates integral beyond supply rails without op-amp saturation; has analog integrator bandwidth that extends into the limited gain low frequency region; avoids drift due to low pass filter effects and unbalanced input biases; and exhibits no sampled data or discrete system effects. Tests on a PCB prototype verified the design.
Novel Three-component Zeolite Capsule Catalyst for Direct Synthesis of Isoparaffin (2009)

One zeolite capsule catalyst with core(Co/Al2O3)/shell(H-beta membrane) structure was prepared and used for isoparaffin direct synthesis via FTS reaction. Based on this core/shell zeolite capsule catalyst, a novel palladium painted zeolite capsule catalyst with three-component core (Co/Al2O3)/shell (H-beta membrane)/paint (Pd) structure was designed. In the isoparaffin synthesis on this three-component zeolite capsule catalyst, the olefins effused from the zeolite capsule catalyst were in-situ hydrogenated effectively, mostly converted to isoparaffin.
Mechanism of Phosphor Ylide-Mediated Living Polymerizations of MMA. Nature of Side Reactions in the Formation of Initiators (2006)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Mechanism of Phosphor Ylide-Mediated Living Polymerizations of MMA. Nature of Side Reactions in the Formation of InitiatorsJun Ling and Thieo E. Hogen-EschView Author Information Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661 Cite this: Macromolecules 2006, 39, 26, 9665–9667Publication Date (Web):December 8, 2006Publication History Received4 August 2006Revised19 October 2006Published online8 December 2006Published inissue 1 December 2006https://pubs.acs.org/doi/10.1021/ma061778thttps://doi.org/10.1021/ma061778tbrief-reportACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views277Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Ions,Living polymerization,Metathesis polymerization,Organic compounds Get e-Alerts
DoA Estimation with Compensation of Hardware Impairments (2010)

We consider the estimation of the direction of arrival (DoA) in the presence of hardware impairments that include the RF carrier frequency offsets, the phase offsets generated by an uncalibrated array, and the DC offset. The impairments model has been derived from the analysis of a hardware multiple antenna test-bed that uses direct down-conversion RF front-ends. The performance of the proposed algorithm has been investigated both analytically and via simulations. We show that the estimator provides good performance for a wide range of angles and it is robust to the hardware impairments.
First demonstration and performance of AlGaN based focal plane array for deep-UV imaging (2009)

We present several prototypes to extend the range of AlGaN focal plane arrays from near UV to deep UV range (200 nm - 4 nm). Arrays include 320x256 pixels with a pitch of 30 &#956;m and are based on Schottky photodiodes. AlGaN is grown on a silicon substrate. After a flip-chip hybridization, silicon substrate is thinned and removed by dry etching. The tricky point is to maintain the membrane integrity. By using a honeycomb structure in the Si substrate, after hybridization, we were able to keep the membrane plane and rigid, avoid the crack expansion, and thus maintain the membrane integrity. The structure includes an Al<sub>.35</sub>Ga<sub>.65</sub>N active layer grown on a thick Al<sub>.55</sub>Ga <sub>.45</sub>N window layer, with a graded AlGaN layer in between. The high quality materials are grown by MBE. The Al<sub>.55</sub>Ga<sub>.45</sub>N window layer is also thinned by dry etching down to the gradual layer and desertion layer where a higher internal electric field takes place. The results show that the dry etching process doesn't affect the readout circuit properties. The dark current is negligible and non uniformity in etching slightly contributes into a constant offset. The measured noise factor, a bit more than 100 electrons rms, is due to reset noise in the integration capacitance and in other parasitic capacitances. With a peak response at 300 nm of 35%, the responsivity is 1% at 266 nm and in the deep UV range. The spectral responsivity measured on a synchrotron line at a wavelength of 2nm reaches more than 200% due to multiple photoexcitation.
Mechanical Alternans Is Associated With Mortality in Acute Hospitalized Heart Failure (2014)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01557465.
Validation of vortex-lattice method for loads on wings in lift-generated wakes (1995)

A study is described that evaluates the accuracy of vortex-lattice methods when they are used to compute the loads induced on aircraft as they encounter lift-generated wakes. The evaluation is accomplished by the use of measurements made in the 80 by 120 ft Wind Tunnel of the lift, rolling moment, and downwash in the wake of three configurations of a model of a subsonic transport aircraft. The downwash measurements are used as input for a vortex-lattice code in order to compute the lift and rolling moment induced on wings that have a span of 0.186, 0.510, or 1.022 times the span of the wake-generating model. Comparison of the computed results with the measured lift and rolling-moment distributions the vortex-lattice method is very reliable as long as the span of the encountering or following wing is less than about 0.2 of the generator span. As the span of the following wing increases above 0.2, the vortex-lattice method continues to correctly predict the trends and nature of the induced loads, but it overpredicts the magnitude of the loads by increasing amounts.
Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer (2008)

This indicates that epigenetic changes affect the expression of the Smad4 protein in prostate cancer and points to methylation of the promoter as a novel marker of and contributor to the disease warranting further study.
Modified point diffraction interferometer to evaluate tolerances in the design of progressive addition lenses (2013)

The main goal of this work is to show the principles, design and performance of a modified point diffraction interferometer to evaluate the local higher order aberrations of progressive addition lenses in order to analyze the tolerances in the design of these ophthalmic components for a reasonable level of comfort by the different users. We also present a detailed analysis of high order aberrations in circular regions within the four most relevant regions of interest of this kind of lenses.
Polarization-dependent SOA-based PolSK modulation for turbulence-robust FSO communication (2021)

This paper proposes a polarization-dependent semiconductor optical amplifier (SOA)-based polarization shift keying (PolSK) modulation for turbulence-robust free-space optical (FSO) communication. Based on the nonlinear gain and polarization characteristics, the PolSK signal is modulated by the optical bit inversion using the polarization-dependent SOA and linear polarizer (LP). The capability of scintillation mitigation is analyzed under both balanced and polarization-independent SOA-based detections. The proposed technique is evaluated in experiments. The experimental results demonstrated that the bit-error-rate (BER) performance of the proposed technique was close to the conventional Mach-Zehnder modulator (MZM)-based PolSK modulation under various scintillation effects.
Identification of Dirofilaria immitis larval antigens with immunoprophylactic potential using sera from immune dogs (1992)

Previous research has demonstrated that dogs that received chemically abbreviated Dirofilaria immitis larval infections were significantly immune to challenge infections. Sera from those immune animals have been effective in passively transferring larval killing and stunting. In the present study, sera from immune and control animals were used to screen various Ag subsets for unique Ag. Through Western blot analysis of larval extracts and excretory-secretory products, and immunoprecipitation of metabolically labeled proteins and larval surface Ag, it was determined that as many as 12 molecules were uniquely recognized by protective immune sera. A 39-kDa molecule was present in both soluble lysates of third- and fourth-stage larvae and larval excretory-secretory products; it was recognized by each of the immune dogs and by none of the infected or uninfected control animals. The 39-kDa molecule appeared to be absent from adults and microfilariae of the parasite. In addition to the unique recognition by immune dog sera, larval stage specificity of this molecule suggests that it may be useful as a vaccine candidate.
A Monte Carlo algorithm to measure probabilities of rare events in cluster-cluster aggregation (2022)

We develop a biased Monte Carlo algorithm to measure probabilities of rare events in cluster-cluster aggregation for arbitrary collision kernels. Given a trajectory with a fixed number of collisions, the algorithm modifies both the waiting times between collisions, as well as the sequence of collisions, using local moves. We show that the algorithm is ergodic by giving a protocol that transforms an arbitrary trajectory to a standard trajectory using valid Monte Carlo moves. The algorithm can sample rare events with probabilities of the order of $10^{-40}$ and lower. The algorithm's effectiveness in sampling low-probability events is established by showing that the numerical results for the large deviation function of constant-kernel aggregation reproduce the exact results. It is shown that the algorithm can obtain the large deviation functions for other kernels, including gelling ones, as well as the instanton trajectories for atypical times. The dependence of the autocorrelation times, both temporal and configurational, on the different parameters of the algorithm is also characterized.