gebhart/patrepeval huggingface dataset:
Unconstrained Monitoring of Biological Signals Using an Aortic Pulse Wave Sensor (2018)

This paper proposes a system to extract biological signals from aortic pulse waves which are measured by a microphone type pulse wave sensor. Theproposed system enables extraction of three biological signals corresponding to respiratory rate, pulse pressure wave, and RR interval simply by sitting on the seat on which the sensor is laid. Experiment results demonstrated that the mean absolute errors between the signals measured by the proposed system and the conventional sensors are as low as 0.38 times per minute for the respiratory rate, 11.2 mmHg for the pulse pressure wave, and 16.6 ms for the RR interval. The proposed system thus may be applied to monitor the physiological state of a human subject to prevent accident caused by health condition.
Cross-linked Polyethylenimine as Potential DNA Vector for Gene Delivery with High Efficiency and Low Cytotoxicity (2006)

Polyethylenimine (PEI) has been known as an efficient gene carrier with the highest cationic charge potential. High transfection efficiency of PEI, along with its cytotoxicity, strongly depends on its molecular weight. To enhance its gene delivery efficiency and minimize cytotoxicity, we have synthesized small cross-linked PEI with biodegradable linkages and evaluated their transfection efficiencies in vitro. In this study, branched PEI with a molecular weight of 800 Da was cross-linked by small diacrylate [1,4-butanediol diacrylate or ethyleneglycol dimethacrylate (EGDMA)] for 2-6 h. The efficiencies of the cross-linked PEI in in vitro transfection of plasmid DNA containing enhanced green fluorescent protein (EGFP) reporter gene were assessed in melanoma B16F10 cell line and other cell lines. Flow cytometry was used to quantify the cellular entry efficiency of plasmid and the transgene expression level. The cytotoxicities of the cross-linked PEI in these cells were evaluated by MTT assay. EGDMA-PEI 800-4h, a typical cross-linked PEI reported here, mediated a more efficient expression of reporter gene than the commercially available 25-kDa branched PEI control, and resulted in a 9-fold increase in gene delivery in B16F10 cells and a 16-fold increase in 293T cells, while no cytotoxicity was found at the optimized condition for gene delivery. Furthermore, the transfection activity of polyplexes was preserved in the presence of serum proteins.
Lectin Capture Strategies Combined with Mass Spectrometry for the Discovery of Serum Glycoprotein Biomarkers (2006)

The application of mass spectrometry to identify disease biomarkers in clinical fluids like serum using high throughput protein expression profiling continues to evolve as technology development, clinical study design, and bioinformatics improve. Previous protein expression profiling studies have offered needed insight into issues of technical reproducibility, instrument calibration, sample preparation, study design, and supervised bioinformatic data analysis. In this overview, new strategies to increase the utility of protein expression profiling for clinical biomarker assay development are discussed with an emphasis on utilizing differential lectin-based glycoprotein capture and targeted immunoassays. The carbohydrate binding specificities of different lectins offer a biological affinity approach that complements existing mass spectrometer capabilities and retains automated throughput options. Specific examples using serum samples from prostate cancer and hepatocellular carcinoma subjects are provided along with suggested experimental strategies for integration of lectin-based methods into clinical fluid expression profiling strategies. Our example workflow incorporates the necessity of early validation in biomarker discovery using an immunoaffinity-based targeted analytical approach that integrates well with upstream discovery technologies.
Hemagglutination and adhesiveness of toxigenic Escherichia coli isolated from humans (1979)

Toxigenic strains of Escherichia coli isolated from humans were studied for adherence to human buccal mucosal epithelial cells. The E. coli strains were labeled with 3H-amino acids or fluorescein isothiocyanate. Toxigenic E. coli strains varied in their ability to adhere in the presence of mannose. Of 32 toxigenic strains examined, 52% bound to the buccal cells, whereas none of 8 control strains did so (Mann-Whitney U test, P =0.007). The control strains were nontoxigenic E. coli isolates from humans, enterotoxigenic E. coli isolates from animals, and E. coli K-12 containing the K88 or K99 plasmid; these strains exhibited only background-level adherence in this assay. Among the toxigenic E. coli strains that bound to human buccal mucosal cells, there was no correlation with mannose-resistant hemagglutination (MR-HA) of guinea pig and human erythrocytes. Screening 32 strains, we found the following phenotypes: (i) MR-HA+, buccal adherent; (ii) MR-HA+, buccal nonadherent; (iii) MR-HA-, buccal adherent. Presumably the third group represents strains with another type(s) of surface attachment components not involved in the MR-HA reaction. Our findings indicate that a number of bacterial surface structures can function in MR-HA and buccal adherence.
Slaker grits from the causticising process of a pulp mill &ndash; a potential fertiliser and liming agent material for use in agriculture and forestry (2010)

The total heavy metal concentrations in the slaker grits were clearly lower than current Finnish limit values for fertilisers used in agriculture and in forestry. This result, together with the strongly alkaline pH (13), the elevated total calcium concentration (331 g kg−1; d.w.), the existence of calcite (CaCO3), as well as the neutralising value of 39.4-% (Ca equivalents, d.w.), according to which, 0.96 tonnes of slaker grits would be required to replace 1 tonne of a commercial ground limestone product, indicate that the slaker grits are a potential fertiliser and liming agent material for use in agriculture and forestry.
Simulation of Orientation Distribution Function in Rolling of High Density Polyethylene Film Calculated with the Plastic Slip Model. Part II. Orientation Distribution Function of Each Crystal Plane Normal in Rolling of High Density Polyethylene Film. (1997)

We have evaluated the orientation function of each plane normal for rolling in high density polyethylene films. The pole figure device familiar in X-ray diffraction was used. These distribution functions were compared with a simulation of orientation in crystallites after rolling, by assuming polycrystalline aggregations. We analyzed the mechanism of orientation for the rolling process in which the {110}, ‹001› and (100), ‹001› slip systems dominated in three types of chain slip systems by applying the maximum plastic work principle.
ChemInform Abstract: Shape‐Selective Targeting of DNA by (Phenanthrenequinone diimine)rhodium(III) Photocleaving Agents. (1989)

Abstract The complexes (I) and (II) belong to a family of new, highly efficient, photocleaving molecules, which appear to recognize ostensible B‐form DNA sites on the basis of considerations of shape.
Materials design analysis of the prosthetic anterior cruciate ligament (1980)

Repair or replacement of the damaged anterior cruciate ligament (ACL) is a significant clinical problem. A design utilizing ultrahigh-molecular-weight polyethylene (UHMWPE) was developed and marketed by an orthopaedic device manufacturer. Mechanical failure rates of greater than 10%/year postoperatively raised the issue of the adequacy of UHMWPE in that design. A study has been made to estimate the forces in the human anterior cruciate ligament for young, middle age, and older patients and to thus derive the minimum materials requirements for a now withdrawn prosthetic anterior cruciate ligament (PACL) design. It is concluded that UHMWPE does not possess adequate yield, creep, or fatigue properties to meet the design. Furthermore, consideration of the varying requirements on the PACL, due to differences in age and activity levels of patients, suggest that a band-type design offers a better possibility of achieving adequate materials performance in the ACL prosthetic replacement.
Terpene compounds as drugs. 14. Terpenyl carbamates as central nervous system depressants (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTerpene compounds as drugs. 14. Terpenyl carbamates as central nervous system depressantsGiovanna Minoli, Ernesta Marazzi-Uberti, and Silvano CasadioCite this: J. Med. Chem. 1972, 15, 9, 998Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/jm00279a032https://doi.org/10.1021/jm00279a032research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization and Prevalence of MefA, MefE, and the Associated msr (D) Gene in Streptococcus pneumoniae Clinical Isolates (2004)

Recent work has shown that the efflux genes in Streptococcus pneumoniae that are responsible for acquired macrolide resistance can be distinguished as either mef(E) or mef(A). The genetic elements on which mef(A) and mef(E) are found also carry an open reading frame (ORF) that is 56% homologous to msr(A) in Staphylococcus. The prevalence of mef(A/E) and of the msr-like ORF [msr(D)] was evaluated in 153 mef(+) S. pneumoniae clinical isolates collected in North America, Europe, Africa, and Asia from 1997 to 2002. Clinical isolates were screened with PCR primers specific for either mef(A) or mef(E) and for msr(D). mef(A), mef(E), and msr(D) were cloned from mef(+) strains and transformed into a susceptible, competent strain of S. pneumoniae. The transformants were tested for antimicrobial susceptibilities and efflux pump induction. The results of this work demonstrated that mef(A) is more often isolated in parts of Europe, with some incidence in Canada, and that the msr-like gene alone can confer the efflux phenotype.
openPFGE: An open source and low cost pulsed-field gel electrophoresis equipment (2020)

Abstract DNA electrophoresis is a fundamental technique in molecular biology that allows the separation of DNA molecules up to ~50 Kbp. Pulsed-field gel electrophoresis [PFGE] is a variation of the conventional DNA electrophoresis technique that allows the separation of very large DNA molecules up to ~10 Mbp. PFGE equipment is very expensive and it becomes an access barrier to many laboratories. Also, just a few privative designs of the equipment are available and it becomes difficult for the community to improve or customize their functioning. Here, we provide an open source PFGE equipment capable of the separation of DNA molecules up to, at least, ~2 Mbp and at low cost: USD$850, about 3% of the price of typical commercial equipment. Specifications table
3‐O‐Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway (1982)

We studied in rats the effect of 3-O-methyldopa (OMD) on levodopa-induced rotations after unilateral destruction of the nigrostriatal pathway. Pretreatment of rats with OMD significantly reduced the number of rotations induced by levodopa, compared with the number of rotations obtained in the same rats with levodopa alone.
Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts (2013)

Enzyme replacement therapy for MPS IIIB (mucopolysaccharidosis type IIIB; also known as Sanfilippo B syndrome) has been hindered by inadequate mannose 6 phosphorylation and cellular uptake of rhNAGLU (recombinant human α-N-acetylglucosaminidase). We expressed and characterized a modified rhNAGLU fused to the receptor-binding motif of IGF-II (insulin-like growth factor 2) (rhNAGLU-IGF-II) to enhance its ability to enter cells using the cation-independent mannose 6-phosphate receptor, which is also the receptor for IGF-II (at a different binding site). RhNAGLU-IGF-II was stably expressed in CHO (Chinese-hamster ovary) cells, secreted and purified to apparent homogeneity. The Km and pH optimum of the fusion enzyme was similar to those reported for rhNAGLU. Both intracellular uptake and confocal microscopy suggested that MPS IIIB fibroblasts readily take up the fusion enzyme via receptor-mediated endocytosis that was inhibited significantly (P<0.001) by the monomeric IGF-II peptide. Glycosaminoglycan storage was reduced by 60% (P<0.001) to near background levels in MPS IIIB cells after treatment with rhNAGLU-IGF-II, with half-maximal correction at concentrations of 3-12 pM. A similar cellular uptake mechanism via the IGF-II receptor was also demonstrated in two different brain tumour-derived cell lines. Fusion of rhNAGLU to IGF-II enhanced its cellular uptake while maintaining enzymatic activity, supporting its potential as a therapeutic candidate for treating MPS IIIB.
Computationally Efficient Relay Antenna Selection for AF MIMO Two-Way Relay Channels (2012)

This correspondence develops a computationally efficient scheme to select a subset of relay antennas to maximize the achievable sum rate (ASR) of amplify-and-forward multiple-input multiple-output two-way relay channels. To reduce the computational complexity of antenna selection (AS), two sequential AS algorithms, joint AS (JAS) and separate AS (SAS), are proposed. JAS jointly selects a pair of receive-transmit antennas at each sequential step. In contrast, SAS separates receive and transmit AS into a two-stage algorithm; the receive antenna set is selected first, followed by selection of the transmit antennas. Simulation results show that the proposed algorithms achieve nearly the same ASR as compared to an exhaustive search, but with significantly reduced computational complexity.
β°-Thalassemia Complicated by Autoimmune Hemolytic Anemia (1980)

The unusual occurrence of both beta o-thalassemia and autoimmune hemolytic anemia (AIHA) in a 28-month-old child is reported to illustrate special diagnostic and therapeutic studies. The diagnosis of beta o-thalassemia was established by clinical, family and globin synthesis studies. The diagnosis of AIHA was confirmed by the shortened survival of transfused autologous and homologous red blood cells and by positive direct antiglobulin tests. During treatment of the AIHA were corticosteroids and various immunosuppressive drugs, globin synthesis studies were performed to evaluate the coincidental effects on gamma/alpha-globin chain synthetic ratios. A 50% increase in the gamma/alpha synthetic ratio during cyclophosphamide treatment suggests that further studies of the possible benefits of cytotoxic drug therapy in beta-thalassemia may be indicated.
Impact of asymptomatic genital tract infections on in vitro Fertilization (IVF) outcome (2018)

The results show the negative impact of E. faecalis on sperm quality and the association of definite bacterial pathogens with reduced levels of vaginal lactobacilli. The presence of E. faecalis and/or U. urealyticum and/or M. hominis in genital samples of infertile couples is predictive for a negative outcome of IVF.
Universality in the Genetic Code (1964)

Article MetricsDownloadsCitationsNo data available.0510AugSepOctNovDecJan5270Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Small-Scale Quasi-Static Tests on Non-Slender Piles Situated in Sand (2011)

In the period from February 2009 till March 2011 a series of small-scale tests on pile foundations has been conducted at Aalborg University. In all the tests the piles have been exposed to quasi-static loading and all the tests have been conducted in a pressure tank. The objective of the tests has been to investigate the effect of pile diameter and length to diameter ratio on the soil response in sand for non-slender piles. Further, the tests have been conducted to calibrate a three-dimensional numerical model in the commercial program FLAC3D.
Histomorphometric evaluation of the thin hydroxyapatite layer formed through anodization followed by hydrothermal treatment (1997)

By the previously described method of electrochemical and hydrothermal reaction, a thin hydroxyapatite (HA) layer of 1 microm thickness was formed on machined, grit-blasted, and titanium plasma-sprayed implants, the surfaces of which were equipped with a gap zone of 0.15 mm in depth. These implants, together with HA and titanium plasma-sprayed implants as control materials, were placed in dog mandibles for 4 weeks. Histomorphometrical comparison was performed to examine the effects of the thin HA layer and the surface topography on bone formation. The roughened implants, especially the grit-blasted implants, were surrounded with thin bone newly formed along the rough surfaces and showed higher bone apposition than the smooth implants. The gap zone of the HA plasma-sprayed implant was repaired with new bone that had vertically extended from the surrounding bone. The thin HA layer had as much osteoconduction as a plasma-sprayed HA coating but showed significantly different bone response. The results suggest that bone formation on an HA film is affected by degradation in living tissue that is related to the crystallinity and the chemical composition of the HA film itself.
Focused thermal emission from a nanostructured SiC surface (2016)

Incandescent sources that produce light from electrically heated filaments or films tend to feature low efficiencies and offer poor spectral and angular control. We demonstrate that a judicious nanostructuring of a SiC surface can focus thermal emission of a preselected spectral range to a well-defined height above the surface. SiC is known to support electromagnetic surface waves that afford the required thermal emission control. Here, we provide general design rules for this type of focusing element that can be extended to other material systems, such as metals supporting surface plasmon-polariton waves. These rules are verified using full-wave calculations of the spatial variation of thermal emission. The obtained results establish a foundation for developing more complex algorithms for the design of complex thermal lenses.
Multimodal size spectra of submicrometer particles bearing various elements in rural air (1991)

Samples of size-segregated submicrometer aerosol particles were collected with a microorifice impactor near Deep Creek Lake, a recreational area in rural western Maryland, and analyzed for up to 44 elements by instrumental neutron activation and X-ray fluorescence analyses. Differential concentration vs particle size spectra revealed as many as four distinct submicrometer aerosol modes with diameters between 0.09 and 1.0-mu-m in a single sample. The spectra of many elements, including Al, Zn, Na, K, Br, Ca, Ga, Fe, La, Sb, Ce, Ti, and I contained two or more modes. Modal diameters and S/Se ratios for samples influenced by northeasterly winds were smaller than those influenced by westerly winds, suggesting a greater age for the latter, despite the close proximity of several large coal-fired power plants to the west of the site. Large peaks in the spectra of S, As, Se, Sb, and V occurred at mass median aerodynamic diameters ranging from 0.3 to 0.6-mu-m in both day and nighttime samples. Simple dispersion estimates suggest that large peaks observed in daytime samples must include material from multiple sources, whereas mass in those observed in nighttime samples could be accounted for by single sources.
Collaborative Representation-based Classification Method Using Weighted Multi-scale LBP for Image Recognition (2017)

In this paper, we propose a novel collaborative representation-based classification method using weighted multi-scale LBP for face recognition. First, to capture more useful local information from the dictionary, we constructed a weighted hierarchical multi-scale LBP as a dictionary optimization tool to dig out the multi-scale information of the original samples. Second, a query sample is represented as a linear combination of the most informative weighted multi-scale LBP features, in which the representation capability of each weighted multi-scale LBP feature is measured to determine the "nearest neighbors" for representing the test sample. The final goal of the proposed method is to find an optimal representation of these weighted multi-scale LBP features from the classes with major contributions. Experimental results conducted on the ORL, FERET, AR and GT face databases demonstrate the effectiveness of the proposed method.
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes (2018)

Loss of function of the nuclear deubiquitinating enzyme BRCA1-associated protein-1 (BAP1) is associated with a wide spectrum of cancers. We report that tamoxifen-induced BAP1 deletion in adult mice resulted in severe thymic atrophy. BAP1 was critical for T cell development at several stages. In the thymus, BAP1 was required for progression through the pre-T cell receptor checkpoint. Peripheral T cells lacking BAP1 demonstrated a defect in homeostatic and antigen-driven expansion. Deletion of BAP1 resulted in suppression of E2F target genes and defects in cell cycle progression, which was dependent on the catalytic activity of BAP1, but did not require its interaction with host cell factor-1 (HCF-1). Loss of BAP1 led to increased monoubiquitination of histone H2A at Lys<sup>119</sup> (H2AK119ub) throughout the T cell lineage, in particular in immature thymocytes, but did not alter trimethylation of histone H3 at Lys<sup>27</sup> (H3K27me3). Deletion of BAP1 also abrogated B cell development in the bone marrow. Our findings uncover a nonredundant function for BAP1 in maintaining the lymphoid lineage.
Performance of fixed in-car microphone array beamformer under variations in car noise (2017)

Microphone array beamforming is being increasingly employed in the automotive industry for the suppression of car noise associated with tire friction, wind, and the vehicle engine. In many cases, this noise can be treated as stationary, facilitating fixed, non-adaptive statistically optimal beamformer implementation. This way, the noise properties can be inferred in highly controlled laboratory conditions, leading to a reliable, predictable, and simple beamforming solution. However, although the driving noise is stationary, its acoustic properties may depend on the type of the road on which the vehicle is traveling, e.g. concrete road versus asphalt or new road versus old. Hence, the performance of a fixed beamformer may suffer in a case where it is applied to a road type that differs from the one for which it was designed. In the current work, we study this effect for the widely used family of Minimum Variance Distortionless Response (MVDR) beamformers. The results suggest that the negative impact due to the noise mismatch may be significant in certain frequency bands. Nevertheless, a speech recognition experiment carried out on enhanced voice signals demonstrates that interchanging between the road types investigated here has, overall, a relatively mild effect on the recognition performance.