gebhart/patrepeval huggingface dataset:
T Cell-Mediated, IFN-γ-Facilitated Rejection of Murine B16 Melanomas (1998)

Abstract The murine melanoma cell line B16.F10 (H-2b) was used to study specific T cell responses that reject tumors. Stable B16 transfectants were established that express viral Ags, either the hepatitis B surface Ag (HBsAg) or the large tumor Ag (T-Ag) of SV40. B16 cells and their transfected sublines were CD40+CD44+ but expressed no (or low levels of the) costimulator molecules CD154 (CD40L), CD48, CD54, CD80, and CD86. Surface expression of MHC class I (Kb, Db) and class II (I-Ab) molecules by B16 cells was low, but strikingly up-regulated by IFN-γ. CD95 (Fas) and CD95 ligand (CD95L (FasL)) were “spontaneously” expressed by B16 cells growing in vitro in serum-free medium; these markers were strikingly up-regulated by IFN-γ. B16 cells coexpressing CD95 and CD95L were irreversibly programed for apoptosis. In vitro, noninduced B16 transfectants stimulated a specific IFN-γ release response, but no cytolytic response (in a 4-h assay) in MHC class I-restricted CTL; in contrast, IFN-γ-induced B16 targets were efficiently and specifically lysed by CTL. In vivo, B16 transfectants were specifically rejected by DNA-vaccinated syngeneic hosts through a T-dependent immune effector mechanism. The tumors showed evidence of massive apoptosis in vivo during the rejection process. The data suggest that CTL-derived IFN-γ enhances an intrinsic suicide mechanism of these tumor cells in addition to facilitating lytic interactions of effectors with tumor targets.
Promoting Silk Fibroin Adhesion to Stainless Steel Surfaces by Interface Tailoring (2022)

Bonding dissimilar materials has been a persistent challenge for decades. This paper presents a method to modify a stainless steel surface (316 L), routinely used in medical applications to enable the significant adhesion of a biopolymer (silk fibroin). The metallic surface was first covalently grafting with polyacrylamide, to enable a hydrogen bonding compatible surface. The polymerisation was initiated via the irreversible electrochemical reduction of a 4-nitrobenzene diazonium salt (20 mM), in the presence of an acrylamide monomer (1 M) at progressively faster scan rates (0.01 V/s to 1 V/s). Examination of the modified samples by FT-IR was consistent with successful surface modification, via observations of the acrylamide carbonyl (1600-1650 cm<sup>-1</sup> ) was observed, with more intense peaks correlating to slower scan rates. Similar observations were made with respect to increasing surface polarity, assessed by water contact angle. Reductions of >60° were observed for the grafted surfaces, relative to the unmodified control materials, indicating a surface able to undergo significant hydrogen bonding. The adhesion of silk to the metallic surface was quantified using a lap shear test, effectively using silk fibroin as an adhesive. Adhesion improvements of 5-7-fold, from 4.1 MPa to 29.3 MPa per gram of silk fibroin, were observed for the treated samples, highlighting the beneficial effect of this surface treatment. The methods developed in this work can be transferred to any metallic (or conductive) surface and can be tailored to complement any desired interface.
The PRoBe-SH: A Close-Coded Patient-Reported Survey Tool to Assess Breast Surgery History (2022)

Background: Diagnosis and treatment of breast cancer often involves several surgical procedures. Women with breast cancer are asked repeatedly to report their breast surgery history, often elicited in an open-ended format and relying on patient recall. Electronic medical records (EMR) and other medical documentation are not always readily available. No comprehensive, validated patient-reported measure of breast surgery history exists. We developed a close-coded, digital survey tool to elicit patient-reported breast surgery history (PRoBe-SH). Methods: We administered the PRoBe-SH survey tool to a convenience sample of patients with a history of breast cancer. We compared PRoBe-SH data to both surgical history documented in patients’ EMR and open-ended surgical history ascertained from patient-completed clinic intake forms. Sensitivity/specificity analyses and McNemar’s tests were performed. Results: Data from fifty patients (median age 53.5 years, range 31-71, 70% non-Hispanic white) were analyzed. The sensitivity of the PRoBe-SH for accurately identifying surgical history was 100% for mastectomy, lumpectomy 96%, mastectomy sidedness 100% (right) and 100% (left), lumpectomy sidedness 36% (right) 55% (left), lymphadenectomy 64%, breast reconstruction 89%, and presence of a native nipple 100% (right) and 100% (left). Open-ended surgical history was more than 90% sensitive for identifying mastectomy and lumpectomy only. The PRoBe-SH was significantly more sensitive than open-ended surgical history for identifying mastectomy sidedness (P&lt;0.01), lymphadenectomy (P&lt;0.01), and breast reconstruction (P&lt;0.01). Conclusion: Ascertaining accurate breast surgical history is important in the context of clinical care and for research purposes. The PRoBe-SH is a comprehensive, highly sensitive alternative to obtaining an open-ended breast surgical history when EMR data or other medical documentation are not available.
Distance computation using axis aligned bounding box (AABB) parallel distribution of dynamic origin point (2013)

Performing accurate and precise collision detection method between objects in virtual environment application such as computer games and medical simulation is important in computer graphics research and development. Given pair of objects that near colliding, numerous mechanic has been developed by researchers in order to minimize computation time and increase accuracy of the detection. However, most of these techniques required a lot of computational cost, extra processing power and complex algebraic equations just to solve distance between near colliding objects. In this paper, we described an alternate technique, which is a theoretical framework of novel technique in order to find the optimum closest distance between two or more convex polyhedral in virtual environment application. Given pair of near colliding objects, we proposed an easy to implement mechanism using dynamic origin point by creating inner and middle Axis Aligned Bounding-Box just to find closest distance between objects. We believed that the technique is suitable to be used in any game engine tools for computer games and medical simulation.
High‐Mobility Field‐Effect Transistors Fabricated with Macroscopic Aligned Semiconducting Polymers (2014)

A record high OFET hole mobility, as high as 23.7 cm(2) /Vs, is achieved in macroscopic aligned semiconducting polymers. The high mobility is insensitive to the polymer molecular weight. Polymer chains are aligned along the fiber to facilitate intrachain charge transport.
Rate-Dependent Analysis of the Asymptotic Behavior of Channel Polarization (2012)

We consider the asymptotic behavior of the polarization process in the large block-length regime when transmission takes place over a binary-input memoryless symmetric channel <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$W$</tex></formula> . In particular, we study the asymptotics of the cumulative distribution <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\BBP(Z_{n}\leq z)$</tex></formula> , where <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\{Z_{n}\}$</tex> </formula> is the Bhattacharyya process associated with <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$W$</tex> </formula> , and its dependence on the rate of transmission. On the basis of this result, we characterize the asymptotic behavior, as well as its dependence on the rate, of the block error probability of polar codes using the successive cancellation decoder. This refines the original asymptotic bounds by Arıkan and Telatar. Our results apply to general polar codes based on <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\ell\times\ell$</tex></formula> kernel matrices. We also provide asymptotic lower bounds on the block error probability of polar codes using the maximum a posteriori (MAP) decoder. The MAP lower bound and the successive cancellation upper bound coincide when <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\ell=2$</tex> </formula> , but there is a gap for <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\ell &gt; 2$</tex></formula> .
Serum- and albumin-free cryopreservation of endothelial monolayers with a new solution (2018)

Cryopreservation is the only long-term storage option for the storage of vessels and vascular constructs. However, endothelial barrier function is almost completely lost after cryopreservation in most established cryopreservation solutions. We here aimed to improve endothelial function after cryopreservation using the 2D-model of porcine aortic endothelial cell monolayers. The monolayers were cryopreserved in cell culture medium or cold storage solutions based on the 4°C vascular preservation solution TiProtec<sup>®</sup>, all supplemented with 10% DMSO, using different temperature gradients. After short-term storage at -80°C, monolayers were rapidly thawed and re-cultured in cell culture medium. Thawing after cryopreservation in cell culture medium caused both immediate and delayed cell death, resulting in 11 ± 5% living cells after 24 h of re-culture. After cryopreservation in TiProtec and chloride-poor modifications thereof, the proportion of adherent viable cells was markedly increased compared to cryopreservation in cell culture medium (TiProtec: 38 ± 11%, modified TiProtec solutions ≥ 50%). Using these solutions, cells cryopreserved in a sub-confluent state were able to proliferate during re-culture. Mitochondrial fragmentation was observed in all solutions, but was partially reversible after cryopreservation in TiProtec and almost completely reversible in modified solutions within 3 h of re-culture. The superior protection of TiProtec and its modifications was apparent at all temperature gradients; however, best results were achieved with a cooling rate of -1°C/min. In conclusion, the use of TiProtec or modifications thereof as base solution for cryopreservation greatly improved cryopreservation results for endothelial monolayers in terms of survival and of monolayer and mitochondrial integrity.
Shape metamorphism using p-Laplacian equation (2004)

We present a new approach for shape metamorphism, which is a process of gradually changing a source shape (known) through intermediate shapes (unknown) into a target shape (known). The problem, when represented with implicit scalar function, is under-constrained, and regularization is needed. Using the p-Laplacian equation (PLE), we generalize a series of regularization terms based on the gradient of the implicit function, and we show that the present methods lack additional constraints for a more stable solution. The novelty of our approach is in the deployment of a new regularization term when p /spl rarr/ /spl infin/ which leads to the infinite Laplacian equation (ILE). We show that ILE minimizes the supremum of the gradient and prove that it is optimal for metamorphism since intermediate solutions are equally distributed along their normal direction. Applications of the proposed algorithm for 2D and 3D objects are demonstrated.
A multi-level-cell spin-transfer torque memory with series-stacked magnetotunnel junctions (2010)

We first report a multi-level-cell (MLC) spin-transfer torque memory (SPRAM) with series-connected magnetotunnel junctions (MTJs). The series MTJs (with different areas) show multi-level resistances by a combination of their magnetization directions. A four-level operation by spin-transfer-torque writing was experimentally demonstrated. A scheme for the write/read operation of the MLC SPRAM was also presented.
Diagonals of Rational Functions: From Differential Algebra to Effective Algebraic Geometry (2022)

We show that the results we had previously obtained on diagonals of 9- and 10-parameter families of rational functions in three variables x, y, and z, using creative telescoping, yielding modular forms expressed as pullbacked 2F1 hypergeometric functions, can be obtained much more efficiently by calculating the j-invariant of an elliptic curve canonically associated with the denominator of the rational functions. These results can be drastically generalized by changing the parameters into arbitrary rational functions of the product p=xyz. In other cases where creative telescoping yields pullbacked 2F1 hypergeometric functions, we extend this algebraic geometry approach to other families of rational functions in three or more variables. In particular, we generalize this approach to rational functions in more than three variables when the denominator can be associated to an algebraic variety corresponding to products of elliptic curves, or foliations in elliptic curves. We also extend this approach to rational functions in three variables when the denominator is associated with a genus-two curve such that its Jacobian is a split Jacobian, corresponding to the product of two elliptic curves. We sketch the situation where the denominator of the rational function is associated with algebraic varieties that are not of the general type, having an infinite set of birational automorphisms. We finally provide some examples of rational functions in more than three variables, where the telescopers have pullbacked 2F1 hypergeometric solutions, because the denominator corresponds to an algebraic variety that has a selected elliptic curve.
A tool for securely integrating legacy systems into a distributed environment (2003)

Legacy systems provide services that remain useful beyond the means of the technology in which they were originally implemented. Our Legacy Wrapper tool packages the services of a legacy application in order to redistribute as a distributed object. In this new environment, the wrapper provides its own layer of security between the security domain of the host and the distributed object system. This security layer includes a sandbox for the application that is designed to protect the application against malicious users and the host from malicious applications. In this paper we present the Legacy Access model and the Legacy Wrapper system. The Legacy Access model is an original system access model that presents a four tiered sandboxing model for wrapping legacy applications: complete encapsulation, shared sandbox, single sandbox, sandboxless operation. The Legacy Wrapper tool is an implementation of the model that combines wrapping an application for security purposes with wrapping it for distribution in a distributed object system.
An experimental comparison of the refrigerant flow along adiabatic and diabatic coiled capillary tubes. (2014)

This paper presents experimental comparison of the R134a flow through lateral coiled capillary tubes-suction line heat exchanger (diabatic) and adiabatic coiled capillary tubes in vapor compression refrigeration cycle (VCRC). The experimental results illustrated that mass flux ratio (Gc/Gs) is main parameter that affects metastable flow through non-adiabatic coiled capillary tube. Therefore, an increase of the mass flux ratio represents a decrease of the heat transfer rate between the capillary tube and suction line. The measured and saturated pressure distribution also proof that metastable flow in the non-adiabatic coiled capillary tube with 1.397 mm inner diameter, 30 mm coil diameter, 4360 mm length, 4 mm inner diameter of suction tube exists, when the heat transfer rate between the coiled capillary tube and the suction line is weak with mass flux ratio more than 343.
Anti-interleukin-5 therapy (mepolizumab) in life-threatening asthma attack: A case-based discussion (2019)

We report about a case of a compassionate off-label use of the anti-interleukin-5-agent mepolizumab in a ventilated patient with life-threatening asthma attack in eosinophilic asthma. The patient suffered from severe eosinophilic asthma and was transmitted to our hospital with an asthma attack and a life-threatening respiratory state under ventilation. Since high dose steroids had not yielded a sufficient respiratory improvement mepolizumab was administered subcutaneously. After administration of mepolizumab respiratory state and ventilation parameter improved significantly. Two days after administration the patient was weaned could be extubated 8 days later and recovered completely from the asthma attack. The presented clinical case is suggestive of future clinical trials or registry studies to evaluate potential clinical benefits of anti-interleukin-5 treatment in patients with severe exacerbations of eosinophilic asthma.
Searching for the embedded manifolds in high- dimensional data, problems and unsolved questions (2002)

In a monozygous twin pregnancy, one twin was still-born while the other presented with a severe encephalopathy with seizures, diffuse hypotonia and microcephaly. CT-scan showed cystic lesion in the brain. This type of lesion should be investigated in each "surviving twin".
Modeling and sensorless control of solenoidal actuator (2003)

Electromagnetic actuators (EMA), which incorporate solenoids, are increasingly becoming the actuator of choice in industry lately, due to their ruggedness, low cost, and relative ease of control.Latest applications of solenoid based EMA's include Electromagnetic Valve Actuation (EMV) systems.This application presents challenges that require the improvement of the dynamic characteristics of the EMA.Some of these problems include, but are not limited to, quiet operation, reduced bounce, less energy consumption, trajectory shaping with a minimum number of measurements, and high actuation speeds.These demands, coupled with the nonlinear dynamics of the EMA, make the use of classical control strategies a less attractive option.A possible attempt to arrive at intermediate solutions to these problems should include some amount of model based robust control strategy.This includes the development of an accurate but simple control based model and a robust digital control strategy.In this study a basic nonlinear model for a solenoidal EMA will be developed, and validated, which will include bounce, leakage inductance and temperature effects.The model is formulated for the linear legion (region before saturation) of the actuator dynamics, but validation will include operation in the saturation region as well.This iii effectively means that a nonlinear model will be developed that is simple but accurate enough for control, neglecting hysteresis and magnetic saturation.Next, an EMV will be designed and built.A nonlinear model for the EMV will be developed and validated.This model will include secondary nonlinearities like saturation, hysteresis, mutual inductance and bounce.In this study a variable that is easier and cheaper to measure, current, will be measured and the information of the position and velocity variables will be estimated from this measurement.The position estimate will be used for control.This is called Sensorless Control.The control objective is to reduce impact noise and seating velocity.The sliding mode methodology will be used here since it is nonlinear, robust to uncertainties, and easier to design and implement.The estimation and control algorithms will be validated in simulation and experimentally for the EMA and EMV, respectively.
Generalizations of Gleason's theorem on weight enumerators of self-dual codes (1972)

Gleason has recently shown that the weight enumerators of binary and ternary self-dual codes are polynomials in two given polynomials. In this paper it is shown that classical invariant theory permits a straightforward and systematic proof of Gleason's theorems and their generalizations. The joint weight enumerator of two codes (analogous to the joint density function of two random variables) is defined and shown to satisfy a MacWilliams theorem. Invariant theory is then applied to generalize Gleason's theorem to the complete weight enumerator of self-dual codes over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(3)</tex> , the Lee metric enumerator over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(5)</tex> (given by Klein in 1884!) and over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(7)</tex> (given by Maschke in 1893!), the Hamming enumerator over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(q)</tex> , and over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(4)</tex> with all weights divisible by 2, the joint enumerator of two self-dual codes over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(2)</tex> , and a number of other results.
A Determination of Parameters in Potassium Dihydrogen Arsenate and Silver Arsenate (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Determination of Parameters in Potassium Dihydrogen Arsenate and Silver ArsenateLindsay Helmholz and Robert LevineCite this: J. Am. Chem. Soc. 1942, 64, 2, 354–358Publication Date (Print):February 1, 1942Publication History Published online1 May 2002Published inissue 1 February 1942https://doi.org/10.1021/ja01254a036Request reuse permissionsArticle Views86Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (513 KB) Get e-Alertsclose Get e-Alerts
Diabetic Endothelial Cells Differentiated From Patient iPSCs Show Dysregulated Glycine Homeostasis and Senescence Associated Phenotypes (2021)

Induced pluripotent stem cells derived cells (iPSCs) not only can be used for personalized cell transfer therapy, but also can be used for modeling diseases for drug screening and discovery <i>in vitro.</i> Although prior studies have characterized the function of rodent iPSCs derived endothelial cells (ECs) in diabetes or metabolic syndrome, feature phenotypes are largely unknown in hiPSC-ECs from patients with diabetes. Here, we used hiPSC lines from patients with type 2 diabetes mellitus (T2DM) and differentiated them into ECs (dia-hiPSC-ECs). We found that dia-hiPSC-ECs had disrupted glycine homeostasis, increased senescence, and impaired mitochondrial function and angiogenic potential as compared with healthy hiPSC-ECs. These signature phenotypes will be helpful to establish dia-hiPSC-ECs as models of endothelial dysfunction for understanding molecular mechanisms of disease and for identifying and testing new targets for the treatment of endothelial dysfunction in diabetes.