gebhart/patrepeval huggingface dataset:
Challenges and Perspectives of the Phase Formation of Internally Oxidized PIT-Type Nb3Sn Conductors (2020)

Promising results of internally oxidized conductors based on Bruker's Powder-In-Tube (PIT) design are presented. SnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> was used as an oxygen source and Nb1Zr/Nb2.5Ti were chosen as the Nb alloy precursor. At a reduced field of B/B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c2</sub> = 0.5, an increase of more than 70% in non-Cu Jc against a standard PIT reference was measured. No correlation between oxygen content of the conductor core and grain size was observed. The performance increase was attributed to nanoscale precipitates that act as APC's and lead to an increased point pinning component in the internally oxidized samples. The lack of grain refinement is seen as the result of the formation of Nb-Sn intermetallics prior to the oxygen release and Nb3Sn formation that inhibit an adequate oxygen supply to the Nb alloy.
Towards supporting GPS-unequipped vehicles in inter-vehicle geocast (2004)

IVG (inter vehicle geocast) is a GPS-based inter-vehicle communication mechanism used for alarm message dissemination among vehicles in a highway in risk situations. In this paper, we propose an improvement to IVG towards supporting its interoperability in environments where "GPS-U" GPS-unequipped vehicles are present. They are vehicles that are not equipped with GPS devices or they have some problems to obtain their positions, via GPS, due to some obstacles. The proposed solution allows GPS-U vehicle to compute its position with the help of its neighbors that are equipped with GPS devices, called GPS-E neighbors. Analyses show that the optimal performances of IVG can be reached even when the rate of GPS-U vehicle is 40%.
Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis (2015)

The extracellular matrix plays an essential role for stem cell differentiation and niche homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche microenvironment remain poorly characterized. Here, we uncover an association between the niche and blood cells, leading to the formation of the Drosophila ovarian germline stem cell niche basement membrane. We identify a distinct pool of plasmatocytes tightly associated with the developing ovaries from larval stages onward. Expressing tagged collagen IV tissue specifically, we show that the germline stem cell niche basement membrane is produced by these "companion plasmatocytes" in the larval gonad and persists throughout adulthood, including the reproductive period. Eliminating companion plasmatocytes or specifically blocking their collagen IV expression during larval stages results in abnormal adult niches with excess stem cells, a phenotype due to aberrant BMP signaling. Thus, local interactions between the niche and blood cells during gonad development are essential for adult germline stem cell niche microenvironment assembly and homeostasis.
Estudio de la aplicación de factores de corrección analíticos sobre los resultados experimentales del ensayo "off-axis" (1997)

II CONGRESO NACIONAL DE MATERIALES COMPUESTOS. Celebrado en Madrid, 25 al 28 de noviembre, 1997
Nonlinear circuit foundations for nanodevices, part I: the four-element torus (2003)

Not all molecular and nanodevices are useful from an information technology perspective. Such devices are said to be inept in a precise technical sense that can be easily tested from an explicit mathematical criteria to be presented in this two-part tutorial review. Often an inept device can be redesigned into a smart device capable of computing and artificial intelligence by massaging the device's parameters, such as doping, concentration, geometrical profile, chemical moiety, etc., in accordance with the principle of local activity to be articulated in Part II. In particular, designing a smart nanodevice amounts to fine tuning the device parameters into a much smaller niche within the device's locally active parameter region called the edge of chaos where complexity abounds. Molecular and nanodevices will remain novelty toys for nanodevice specialists unless they possess realistic nonlinear circuit models so that future nano circuit designers can simulate their exotic designs as easily and accurately as current CMOS circuit designers. A mathematically consistent theory for modeling nonlinear, high-frequency nanodevices, specially those which exploited exotic tunneling and entanglement quantum mechanical effects, such as Coulomb blockade, quasi-particle dynamics, Kondo resonance, Aharonov-Bohm nonlocal interactions, etc., will require the introduction of a complete family of fundamental circuit elements as model building blocks. They are presented via a doubly periodic table of circuit elements somewhat reminiscent of Mendeleev's periodic table of chemical elements. These fundamental circuit elements can be compactly represented by a loop of four generic species of circuit elements wrapped around the surface of a torus where any higher order element having an arbitrarily high order of frequency dependence can be generated from one of them, modulo the integer 4, ad infinitum. The significance of this four-element torus is that realistic circuit models of all current and future molecular and nanodevices must necessarily build upon an appropriate subset of nonlinear circuit elements begotten from this torus.
Multicentre, randomised, open-label, parallel-group, clinical phase II study to evaluate immunonutrition in improving efficacy of immunotherapy in patients with metastatic non-small cell lung cancer, undergoing systematic nutritional counseling (2022)

This study is registered on ClinicalTrials.gov Identifier: NCT05384873.
Spontaneous Formation of a Cross-Linked Supramolecular Polymer Both in the Solid State and in Solution, Driven by Platinum(II) Metallacycle-Based Host–Guest Interactions (2019)

The recent progress in platinum(II) coordination-driven supramolecular polymers has had a substantial effect on the design of functional soft materials. However, the prospect of realizing polymerization induced by platinum(II) metallacycle-based host-guest interactions has received little attention until recently. Here we report the realization of supramolecular polymerization driven by platinum(II) metallacycle-based host-guest interactions both in the solid state and in solution. On the basis of the disclosed polymerization mechanism, we present a new strategy for the preparation of platinum(II) metallacycle-based supramolecular polymers.
Die Schmerzmatrix (2019)

Der kleine Gehirnversteher reißt die Sprachbarriere ein, die die Hirnforschung zwischen uns und unserem Gehirn errichtet hat. Jedes der fünfunddreißig kurzen, erhellenden und unterhaltsamen Kapitel erklärt einen grundlegenden Begriff der Hirnforschung anhand einer ungewöhnlichen Geschichte. Leicht zu lesen, vollständig und extrem lehrreich: das erste Buch, das den Leser zum Gehirnversteher macht.
Directional reactive ion etching at oblique angles (1980)

Directional reactive ion etching (RIE) at oblique angles is possible using a simple grid-covered structure (Faraday cage) in conventional parallel-plate sputter etching equipment. Oblique-angle etching, as is possible in any ion-beam system, has been demonstrated using the etchant ions from CHF3 gas on a fused-silica substrate. The first detailed measurements of the angular etch dependence of RIE show a strong similarity to those of an ion-beam system (no chemical etching).
Narcolepsy and H1N1 vaccine (2015)

Narcolepsy is a sleep disorder described as excessive sleepiness with abnormal sleep pattern characterized by uncontrollable rapid eye movement (REM) attacks, in which the preceding non-REM stage is absent. These attacks can occur at any time of the day and can be accompanied by a loss of muscle tone. A plethora of data indicates that narcolepsy is caused by a lack of orexin, an important neurotransmitter involved in the regulation of the sleep cycle. Normal levels of orexin are needed for the correct function of different processes in the body, including feeding, cardiovascular regulation, emotions, and locomotion. The pathogenesis of narcolepsy has been debated for many years. It has been suggested that genetic, autoimmune, or infectious processes may be involved. An important aspect in the etiology of narcolepsy is some reports demonstrating a correlation between its onset and infections or H1N1 vaccination.
FDRL Approach for Association and Resource Allocation in Multi-UAV Air-To-Ground IoMT Network (2022)

&lt;p&gt;In 6G networks, unmanned aerial vehicles (UAVs) can serve as aerial flying base stations (AFBS) with aerial mobile edge computing (AMEC) server capabilities. AFBS is an increasingly popular solution for delivering time-sensitive applications, extending network coverage, and assisting ground base stations in the healthcare systems for remote areas with limited infrastructure. Furthermore, the UAVs are deployed in the healthcare system to support the Internet of medical things (IoMT) devices in data collection, medical equipment distribution, and providing smart services. However, ensuring the privacy and security of patients' data with the limited UAV resources is a major challenge. In this paper, we present a federated deep reinforcement learning framework for resource allocation in UAV-enabled healthcare systems, where IoMT devices send their trained model parameters without transmitting sensitive raw data to the AMEC server. In the proposed framework, the IoMT device is associated with AFBS based on the quality of the data and its demand in order to maximize learning efficiency and accuracy. This work aims to minimize the computation costs of the IoMT devices while considering UAV resources and the fairness of UAV coverage. Simulation results prove that our proposed algorithm outperforms other baseline algorithms in learning accuracy and computational cost.&lt;/p&gt;
Phase I Trial of Rosiglitazone in FSGS (2008)

Rosiglitazone therapy was safe and well tolerated. PK assessment of potential novel therapies for resistant FSGS is necessary to define appropriate dosing regimens. There is rationale to evaluate the efficacy of rosiglitazone as an antifibrotic agent for resistant FSGS in Phase II/III clinical trials.
An improved strategy for determining resonance assignments for isotopically enriched proteins and its application to an engineered domain of staphylococcal protein A (1993)

Sequence-specific resonance assignments provide the basis for interpreting multidimensional NMR spectra and for determining 3D structures of proteins from these data. We have developed an improved strategy for determining these sequence-specific NMR assignments in small proteins and applied this method in determining proton and nitrogen resonance assignments for an 8.2-kDa engineered domain (the Z-domain) of the cell wall protein A of Staphylococcus aureus. First, HCCNH-TOCSY [Lyons, B. A. & Montelione, G.T. (1993) J. Magn. Reson. 101B, 206] data were used together with 2D 2QF-COSY, TOCSY, and 15N-HSQC data to identify amino acid spin systems. Most asparagine and glutamine spin systems were also identified uniquely from these triple-resonance data. Next, complementary HCC(CO)-NH-TOCSY [Montelione, G. T., et al. (1992) J. Am. Chem. Soc. 114, 10975] data were used to identify sequential connections from the aliphatic H alpha, H beta, H gamma, H delta, and H epsilon resonances of residue i to the amide and nitrogen resonances of residue i + 1. By combined analysis of HCCNH-TOCSY and HCC(CO)NH-TOCSY spectra we have determined most of the proton and nitrogen resonance assignments for the Z-domain. This represents the first example of the use of this triple-resonance technique to determine extensive resonance assignments in a small protein.
Flattening simulations of 3D thick sheets made of fiber composite materials (2015)

Abstract Recently, fiber composite materials have been attracting attention from industry because of their remarkable material characteristics, including light weight and high stiffness. However, the costs of products composed of fiber materials remain high because of the lack of effective manufacturing and designing technologies. To improve the relevant design technology, this paper proposes a novel simulation method for deforming fiber materials. Specifically, given a 3D model with constant thickness and known fiber orientation, the proposed method simulates the deformation of a model made of thick fiber-material. The method separates a 3D sheet model into two surfaces and then flattens these surfaces into two dimensional planes by a parameterization method with involves cross vector fields. The cross vector fields are generated by propagating the given fiber orientations specified at several important points on the 3D model. Integration of the cross vector fields gives parameterization with low-stretch and low-distortion.
Road network detection from SPOT imagery for updating geographical information systems in the rural–urban fringe (1992)

Abstract Visual interpretation of high-resolution satellite data has been useful for mapping linear features, such as roads and updating land-use changes. However, it would be beneficial to map new road networks digitally from satellite data to update digital databases using semi-automated techniques. In this paper, an algorithm called Gradient Direction Profile Analysis (GDPA) is used to extract road networks digitally from SPOT High Resolution Visible (HRV) panchromatic data. The roads generated are compared with a visual interpretation of the SPOT HRV multispectral and panchromatic data. The technique is most effective in areas where road development is relatively recent. This is due to the spectral consistency of new road networks. As new road networks are those of most interest to the land manager, this is a useful technique for updating digital road network files within a geographical information system of urban areas.
A Conformation-specific Anti-peptide Antibody to the β-Type Platelet-derived Growth Factor Receptor Also Recognizes the Activated Epidermal Growth Factor Receptor (1995)

Earlier we reported the generation of a conformationspecific antibody (Ab P2) to the fJtype platelet-derived growth factor receptor (Bishayee, S., M~umdar,
Perception of dissonance by people with normal hearing and sensorineural hearing loss (2005)

The purpose of this study was to determine whether the perceived sensory dissonance of pairs of pure tones (PT dyads) or pairs of harmonic complex tones (HC dyads) is altered due to sensorineural hearing loss. Four normal-hearing (NH) and four hearing-impaired (HI) listeners judged the sensory dissonance of PT dyads geometrically centered at 500 and 2000 Hz, and of HC dyads with fundamental frequencies geometrically centered at 500 Hz. The frequency separation of the members of the dyads varied from 0 Hz to just over an octave. In addition, frequency selectivity was assessed at 500 and 2000 Hz for each listener. Maximum dissonance was perceived at frequency separations smaller than the auditory filter bandwidth for both groups of listners, but maximum dissonance for HI listeners occurred at a greater proportion of their bandwidths at 500 Hz than at 2000 Hz. Further, their auditory filter bandwidths at 500 Hz were significantly wider than those of the NH listeners. For both the PT and HC dyads, curves displaying dissonance as a function of frequency separation were more compressed for the HI listeners, possibly reflecting less contrast between their perceptions of consonance and dissonance compared with the NH listeners.
E-029 WEB Flow Disruption: Preliminary Results from WEBCAST trial (2014)

Background and purpose WEBCAST is a European study dedicated to the evaluation of the feasibility, safety, and efficacy of endovascular treatment with WEB of intracranial aneurysms. Materials and methods The study was conducted in 10 European centers. Inclusion criteria were aneurysms located at internal carotid artery bifurcation, middle cerebral artery, basilar artery, and anterior communicating artery with a neck ≥4 mm and a dome to neck ratio ≥ 1. Recanalized aneurysms were not included. Complications and safety data were independently evaluated. Aneurysm occlusion was evaluated at 6 months with DSA by an independent core lab. Aneurysm occlusion was evaluated stable at 6 months in case of complete occlusion, no modification or improvement of the occlusion (versus post-operative occlusion), and no retreatment was performed or foreseen. Results Fifty-one patients (36 females and 15 males) with 51 aneurysms were included between December 2011 and February 2014. Age was between 33 and 75 years (55.6 ± 1.5 years). Forty-eight aneurysms were unruptured and 3 ruptured. Aneurysm location was middle cerebral artery (28 aneurysms), basilar artery (12 aneurysms) internal carotid artery (6 aneurysms), and anterior communicating (5 aneurysms). The feasibility, safety, and efficacy of the treatment is analyzed. Conclusion WEBCAST is the first prospective, multicenter trial evaluating the treatment of intracranial aneurysms with WEB Aneurysm Embolization System. Preliminary results are presented. Disclosures L. Pierot: 2; C; Sequent. L. Spelle: None. V. Costalat: None. I. Szikora: None. J. Klisch: None. D. Herbreteau: None. M. Holtmannspoetter: None. W. Weber: None. T. Liebig: None. C. Cognard: None. A. Bonafé: None. J. Moret: None. J. Byrne: None. A. Molyneux: None.
A phase 1 multicenter open-label dose-escalation study of BMS-936561 (MDX-1203) in clear cell renal cell carcinoma (ccRCC) and B-cell non Hodgkin lymphoma (B-NHL). (2014)

2558 Background: BMS936561 is a fully human monoclonal anti-body conjugate targeting the CD70 transmembrane cell-surface protein highly expressed in ccRCC and B-NHL. The study was designed to determine the safety profile and maximum tolerated dose (MTD) of BMS-936561 in this patient population. Methods: This phase 1 study employed an accelerated titration design followed by a 3+3 dose escalation to evaluate the safety, maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of BMS-936561. Patients with advanced ccRCC or B-NHL, ≤ 3 prior chemotherapy regimens, ECOG performance status 0-2 were treated with escalating doses of BMS-936561 (0.5mg/kg, 1mg/kg, 2mg/kg, 4mg/kg, 8mg/kg, 15mg/kg) by IV infusion every 21 days in a 42 day cycle up to 17 cycles. Dose limiting toxicity (DLT) was defined as any of the following adverse events (AEs): ≥ Grade 4 anemia, leukopenia, thrombocytopenia, neutropenia or any other ≥ Grade 3 events according to NCI CTCAE 3.0 during the first cycle. Results: There were 26 patients enrolled into the escalation (16) and expansion cohorts (10): median age: 63 y, range 48-74; gender: 18M/8F; race: 25W/1AA. BMS-936561 was tested at doses ranging from 0.1 to 15 mg/kg without a defined MTD. There was DLT of grade 3 hypersensitivity in 2/16 (13%) subjects treated at the 15 mg/kg dose cohort. The most commonly reported AEs included fatigue (85%), nausea (54%), decreased appetite (39%), anemia, dyspnea (35% each), constipation, peripheral edema (31% each), vomiting (27%), cough, skin hyperpigmentation, thrombocytopenia (23% each). Delayed toxicities characterized by facial edema and/or pleural or pericardial effusions were observed in 6/16 (38%) subjects treated at the 15mg/kg dose. All treatment emergent grades 3-4 serious AEs occurred in subjects treated at the 15 mg/kg dose. No deaths were attributed to BMS-936561. Exploratory efficacy analysis by investigator assessment showed a best response of stable disease in 18 of 26 patients (69%) without any apparent correlation with the administered dose. Conclusions: BMS936561 is well tolerated over a wide range of doses in patients with advanced ccRCC and B-NHL. Clinical trial information: NCT00944905.
Efficient Exploration of Reactive Potential Energy Surfaces Using Car-Parrinello Molecular Dynamics (2003)

The possibility of observing chemical reactions in ab initio molecular dynamics runs is severely hindered by the short simulation time accessible. We propose a new method for accelerating the reaction process, based on the ideas of the extended Lagrangian and coarse-grained non-Markovian metadynamics. We demonstrate that by this method it is possible to simulate reactions involving complex atomic rearrangements and very large energy barriers in runs of a few picoseconds.
Digital Health Data Quality Issues: Systematic Review (Preprint) (2022)

<sec> <title>BACKGROUND</title> The promise of digital health is principally dependent on the ability to electronically capture data that can be analyzed to improve decision-making. However, the ability to effectively harness data has proven elusive, largely because of the quality of the data captured. Despite the importance of data quality (DQ), an agreed-upon DQ taxonomy evades literature. When consolidated frameworks are developed, the dimensions are often fragmented, without consideration of the interrelationships among the dimensions or their resultant impact. </sec> <sec> <title>OBJECTIVE</title> The aim of this study was to develop a consolidated digital health DQ dimension and outcome (DQ-DO) framework to provide insights into 3 research questions: What are the dimensions of digital health DQ? How are the dimensions of digital health DQ related? and What are the impacts of digital health DQ? </sec> <sec> <title>METHODS</title> Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a developmental systematic literature review was conducted of peer-reviewed literature focusing on digital health DQ in predominately hospital settings. A total of 227 relevant articles were retrieved and inductively analyzed to identify digital health DQ dimensions and outcomes. The inductive analysis was performed through open coding, constant comparison, and card sorting with subject matter experts to identify digital health DQ dimensions and digital health DQ outcomes. Subsequently, a computer-assisted analysis was performed and verified by DQ experts to identify the interrelationships among the DQ dimensions and relationships between DQ dimensions and outcomes. The analysis resulted in the development of the DQ-DO framework. </sec> <sec> <title>RESULTS</title> The digital health DQ-DO framework consists of 6 dimensions of DQ, namely accessibility, accuracy, completeness, consistency, contextual validity, and currency; interrelationships among the dimensions of digital health DQ, with consistency being the most influential dimension impacting all other digital health DQ dimensions; 5 digital health DQ outcomes, namely clinical, clinician, research-related, business process, and organizational outcomes; and relationships between the digital health DQ dimensions and DQ outcomes, with the consistency and accessibility dimensions impacting all DQ outcomes. </sec> <sec> <title>CONCLUSIONS</title> The DQ-DO framework developed in this study demonstrates the complexity of digital health DQ and the necessity for reducing digital health DQ issues. The framework further provides health care executives with holistic insights into DQ issues and resultant outcomes, which can help them prioritize which DQ-related problems to tackle first. </sec>
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport (2017)

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.