gebhart/patrepeval huggingface dataset:
Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis (2015)

Obesity is associated with inflammation and immune cell recruitment to adipose tissue, muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also associated with tissue insulin resistance and can compromise insulin delivery to muscle. The muscle/fat microvascular endothelium mediates insulin delivery and facilitates monocyte transmigration, yet its contribution to the consequences of hyperlipidemia is poorly understood. Using primary endothelial cells from human adipose tissue microvasculature (HAMEC), we investigated the effects of physiological levels of fatty acids on endothelial inflammation and function. Expression of cytokines and adhesion molecules was measured by RT-qPCR. Signaling pathways were evaluated by pharmacological manipulation and immunoblotting. Surface expression of adhesion molecules was determined by immunohistochemistry. THP1 monocyte interaction with HAMEC was measured by cell adhesion and migration across transwells. Insulin transcytosis was measured by total internal reflection fluorescence microscopy. Palmitate, but not palmitoleate, elevated the expression of IL-6, IL-8, TLR2 (Toll-like receptor 2), and intercellular adhesion molecule 1 (ICAM-1). HAMEC had markedly low fatty acid uptake and oxidation, and CD36 inhibition did not reverse the palmitate-induced expression of adhesion molecules, suggesting that inflammation did not arise from palmitate uptake/metabolism. Instead, inhibition of TLR4 to NF-κB signaling blunted palmitate-induced ICAM-1 expression. Importantly, palmitate-induced surface expression of ICAM-1 promoted monocyte binding and transmigration. Conversely, palmitate reduced insulin transcytosis, an effect reversed by TLR4 inhibition. In summary, palmitate activates inflammatory pathways in primary microvascular endothelial cells, impairing insulin transport and increasing monocyte transmigration. This behavior may contribute in vivo to reduced tissue insulin action and enhanced tissue infiltration by immune cells.
Database updating through user feedback in fingerprint-based Wi-Fi location systems (2010)

Wi-Fi fingerprinting is a technique which can provide location in GPS-denied environments, relying exclusively on Wi-Fi signals. It first requires the construction of a database of “fingerprints”, i.e. signal strengths from different access points (APs) at different reference points in the desired coverage area. The location of the device is then obtained by measuring the signal strengths at its location, and comparing it with the different reference fingerprints in the database. The main disadvantage of this technique is the labour required to build and maintain the fingerprints database, which has to be rebuilt every time a significant change in the wireless environment occurs, such as installation or removal of new APs, changes in the layout of a building, etc. This paper investigates a new method to utilise user feedback as a way of monitoring changes in the wireless environment. It is based on a system of “points” given to each AP in the database. When an AP is switched off, the number of points associated with that AP will gradually reduce as the users give feedback, until it is eventually deleted from the database. If a new AP is installed, the system will detect it and update the database with new fingerprints. Our proposed system has two main advantages. First it can be used as a tool to monitor the wireless environment in a given place, detecting faulty APs or unauthorised installation of new ones. Second, it regulates the size of the database, unlike other systems where feedback is only used to insert new fingerprints in the database.
Unique method for controlling device level overlay with high-NA optical overlay technique using YieldStar in a DRAM HVM environment (2018)

This paper demonstrates the improvement using the YieldStar S-1250D small spot, high-NA, after-etch overlay in-device measurements in a DRAM HVM environment. It will be demonstrated that In-device metrology (IDM) captures after-etch device fingerprints more accurately compared to the industry-standard CDSEM. Also, IDM measurements (acquiring both CD and overlay) can be executed significantly faster increasing the wafer sampling density that is possible within a realistic metrology budget. The improvements to both speed and accuracy open the possibility of extended modeling and correction capabilities for control. The proof-book data of this paper shows a 36% improvement of device overlay after switching to control in a DRAM HVM environment using indevice metrology.
Technical implications of proposed graphics standards (Panel Session) (1983)

This panel session is intended to present recent technical developments in the efforts to standardize computer graphics. Several alternative approaches to 3-D standards will be presented and contrasted. The Virtual Device Metafile will be presented, as well as a proposed binding of the GKS standard to Fortran. Presentations will be made by the following individuals: Dr. Peter Bono is the chairman of the ANSI X3H3 technical committee developing standards for Computer Graphics Programming Languages, and will present the current status of the effort to adopt 2-D GKS as an International Standard and as an American National Standard. Tom Wright will be available to respond to questions about the Programmer's Minimal Interface to Graphics (PMIG) proposal, and its current status as a new output level of the draft proposed American National Standard (dpANS) GKS. Mark Skall will present a proposed binding of GKS to the Fortran Language. Mr. Skall will also discuss progress in the field of formal specification of graphics standards and developments in the establishment of conformance/certification procedures for implementations of GKS. Theodore Reed will present the technical content of the Virtual Device Metafile (VDM) draft proposed American National Standard. Discussed will be the relationship of the VDM to GKS and to the yet to be proposed Virtual Device Interface. Specific functionality of the VDM will be discussed as will specific bindings of that functionality as a character set extension and as a binary format. David Shuey will present an overview of the Programmer's Hierarchical Interface to Graphics (PHIGS) proposal. The PHIGS proposal is intended to support hierarchical structuring of graphics data, in contrast to the Core System and GKS proposals. This type of structure addresses highly interactive graphics applications which need to modify the presentation and the relationships within graphics data. Richard Ehlers will present the attribute model of the PHIGS proposal and explore the relationship of attribute model to structured graphics data bases. Also, Mr. Ehlers will discuss the viewing and transformation implications of structured graphics data bases using examples. Gunter Enderle is a member of the West German delegation to the International Standards Organization (ISO) Working Group on Computer Graphics. Herr Enderle will be discussing ISO proposals for the extension of the GKS standard from 2-D to 3-D functionality. Several such proposals have been made, including one by DIN (the official standards making body of the German Federal Republic) and a Norwegian proposal called IDIGS. Elaine Sonderegger was a member of the ACM SIGGRAPH Graphics Standards Planning Committee, and is the ACM SIGGRAPH representative to ANSI X3H3. Ms. Sonderegger will contrast the 3-D functionality of the Core System, IDIGS, DIN proposed 3-D extensions, and PHIGS.
Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models (2014)

These results suggest that ET-743 could represent an alternative chemotherapy for BTC treatment and encourage the development of clinical trials in BTC patients resistant to standard chemotherapy.
The Ketogenic Diet for the Treatment of Epilepsy: A Challenge for Nutritional Neuroscientists (2003)

The ketogenic diet (KD) is a high-fat, low-carbohydrate, adequate-protein diet that has been used for more than eight decades for the treatment of refractory epilepsy in children. Despite this long history, the mechanisms by which the KD exerts its anti-seizure action are not fully understood. Questions remain regarding several aspects of KD action, including its effects on brain biochemistry and energetics, neuronal membrane function and cellular network behavior. With the explosion of the KD use in the last 10 years, it is now imperative that we understand these factors in greater detail, in order to optimize the formulation, administration and fine-tuning of the diet. This review discusses what is known and what remains to be learned about the KD, with emphasis on clinical questions that can be approached in the laboratory. We encourage scientists with a primary interest in nutritional neuroscience to join with those of us in the epilepsy research community to address these urgent questions, for the benefit of children ravaged by intractable seizures.
The conjunctival epithelium in dry eye subtypes: Effect of preserved and non-preserved topical treatments (2001)

The conjunctival inflammation and reduced goblet cell density of dry eye is exacerbated by use of preserved topical agents, and is not significantly improved by use of non-preserved artificial tear supplements alone. Therapeutic strategies for dry eye should aim to increase goblet cell density and control ocular surface inflammation.
The Anthocyanins, Oenin and Callistephin, Protect RPE Cells Against Oxidative Stress (2016)

The retinal pigment epithelium (RPE) is a highly metabolic layer of postmitotic cells lining Bruch's membrane in the retina. While these cells contain endogenous photosensitizers that mediate blue light-induced damage, it has also been shown that blue light exposure damages mitochondrial DNA in RPE cells resulting in mitochondrial dysfunction and unregulated generation of reactive oxygen species (ROS). As RPE cells are postmitotic, it is imperative to decrease oxidative stress to these cells and preserve function. Dietary plant-derived antioxidants such as anthocyanins offer a simple and accessible solution for decreasing oxidative stress. The anthocyanins malvidin-3-O-glucoside (oenin) and pelargonidin-3-O-glucoside (callistephin) were tested for their ability and efficacy in decreasing ROS generation and preserving mitochondrial redox activity in blue light-irradiated ARPE-19 cells. A significant decrease in intracellular ROS with concurrent increase in mitochondrial redox activity was observed for tested concentrations of oenin, while callistephin was beneficial to stressed cells at higher concentrations. These findings suggest anthocyanins are effective antioxidants in blue light-stressed RPE cells in vitro. Additionally, oxidation products of these anthocyanins were examined using LC/MS and findings suggest the possibility of multiple oxidation sites for these compounds.
Effects of naftidrofuryl on the time course of the regional cerebral blood flow in acute ischemic stroke. (1984)

The effects of naftidrofuryl (LS-121), which is known as an activator of the cerebral glucose metabolism in addition to acting as a cerebral vasodilator on the regional cerebral blood flow (rCBF), were investigated in acute and subacute ischemic stroke patients. Six acute patients and 5 subacute patients were treated with 100-200 mg/day of naftidrofuryl for 7-14 days, and the rCBF was measured before and after the treatment by the 133Xe inhalation method. The hemispheric rCBF was significantly increased by 24% for the acute stage and 22% for the subacute stage in the affected side, compared with the stage-matched control group. Naftidrofuryl may accelerate the recovery of the rCBF of the affected hemisphere even in the acute stage.
Ferrocene-o-Benzosemiquinonato Tin(IV) Electron-Transfer Complexes (2013)

The interaction of ferrocene with tin(IV) o-benzosemiquinonato complexes in acetonitrile results in a reversible electron transfer (ET) from ferrocene to the redox-active ligand with the formation of electron-transfer complexes [(3,6-Cat)SnBr3](-)[Cp2Fe](+) (1) and [(3,6-Cat)(3,6-SQ)SnCl2](-)[Cp2Fe](+) (2), where 3,6-Cat is the 3,6-di-tert-butyl-catecholate dianion and 3,6-SQ is the 3,6-di-tert-butyl-o-benzosemiquinonato radical anion. The ET process and the solvent effect in the system "ferrocene-o-benzosemiquinonato tin(IV) complexes" were investigated on the basis of a combination of spectroscopic and X-ray diffraction methods. The molecular structures of 1 and 2 were confirmed by X-ray analysis. Complex 2 demonstrates the ferromagnetic coupling in the linear chain alternating ···D(+•)A(-•)D(+•)A(-•)··· motif.
Antiferroelectric behaviour of achiral mesogenic polymer mixtures (1996)

Abstract X-ray structure determination and pyroelectric and piezoelectric measurements have been carried out on mesogenic mixtures composed of achiral side chain polymers and their monomers. Certain mixtures show antiferroelectric polarization hysteresis loops in the mesophase which was shown to be a bilayered smectic C, while the two components of the mixtures taken alone show no antiferroelectricity. The results obtained on the polymer-monomer mixtures are interpreted in terms of the smectic C structure with alternating tilt which, from a symmetry viewpoint, is allowed to be antiferroelectric. The antiferroelectric mixtures, on being cooled to the glassy state under a d.c. electric field applied, reveal high pyroelectric coefficients with prospects for application as IR detectors.
Notice of Removal: Chemical imaging of tumor microenvironment by using multi-spectral photoacoustic imaging powered by functional nanosensors (2017)

Removed.
ChemInform Abstract: Synthesis and Structure of N‐Alkyl‐2,6‐dimethyl‐4‐oxopyridine‐3‐ carboxylic Acids. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photochemistry of organoborates: intra-ion pair electron transfer to cyanines (1990)

Abstract
BATON: a balanced tree structure for peer-to-peer networks (2005)

Abstract — We propose a balanced tree structure overlay on a peer-to-peer network capable of supporting both exact queries and range queries efficiently. In spite of the tree structure causing distinctions to be made between nodes at different levels in the tree, we show that the load at each node is approximately equal. In spite of the tree structure providing precisely one path between any pair of nodes, we show that sideways routing tables maintained at each node provide sufficient fault tolerance to permit efficient repair. Specifically, in a network with N nodes, we guarantee that both exact queries and range queries can be answered in O(logN) steps and also that update operations (to both data and network) have an amortized cost of O(logN). An experimental assessment validates the practicality of our proposal.
X-ray fluorescence apparatus for use in reservoir management (1987)

We have examined the activity of choline acetyltransferase (ChAT) in rat cortical synaptosomes in the presence of three volatile anaesthetic agents: enflurane, halothane and isoflurane. The Michaelis constant Km, for choline was reduced significantly (P = 0.012) in the presence of 6.5% enflurane (3 rat MAC) compared with control samples exposed to carrier air only, while maximum reaction velocity (Vmax) remained unaltered. The reduction in Km was also significant at enflurane concentrations of 4.4% (2 rat MAC) (P = 0.043) and 2.2% (1 rat MAC) (P = 0.043). Halothane 3% (2.5 rat MAC) and 4.5% isoflurane (3 rat MAC) had no effect on either kinetic property. If present in vivo, an enflurane-induced alteration in acetylcholine metabolism, through modified ChAT, may contribute to the convulsive properties of this anaesthetic.
DSMS (Deep Space Mission System) investment in support of satellite constellations and formation flying (2001)

In this paper we discuss the four classes of constellation/formation support with emphasis of DSMS current status (technology and implementation) and plans in each area.
Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia. (2015)

Polymorphisms in the genes encoding enzymes in the folate metabolism pathway have been associated with male infertility and chromosome abnormalities. The aim of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) polymorphisms in fertile men and infertile men with non-obstructive azoospermia (NOA). A case-control study comprising 85 infertile men with NOA and 246 fertile men as controls was carried out. MTHFR c.677C > T (rs1801133), MTHFR c.1298A > C (rs1801131), MTR c.2756A > G (rs1805087), and MTRR c.66A > G (rs1801394) polymorphisms were determined using the polymerase chain reaction restriction fragment length polymorphism technique. There were significant differences in AC + CC genotype (OR = 1.9, 95% CI = 1.1-3.2) and C allele frequencies (OR = 1.8, 95% CI = 1.2-2.8) of MTHFR c.1298A > C polymorphism between NOA patients and controls after applying the Bonferroni correction. Moreover, the 1298AC genotype, 1298AC + CC genotype, and 1298C allele frequencies were statistically significant in NOA with chromosomal abnormalities and/or a Y chromosome deletion compared to the controls (AC genotype: OR = 3.0; AC + CC genotype: OR = 3.0; C allele: OR = 2.3). Considering the other polymorphisms, no differences were found between cases and controls. Our findings suggest the MTHFR c.1298A > C polymorphism is associated with an increased risk of male infertility, i.e., NOA.
Apical Microleakage of Root-End Cavities Prepared by CO2 Laser (2004)

This in vitro study in extracted human teeth was designed to compare the degree of dye penetration of root-end cavities prepared by CO2 laser, ultrasonic retrotip, or rotary instrument. Eighty-two human anterior teeth were prepared and obturated with laterally condensed gutta-percha and sealer. Root-end resection was performed at 90 degrees, 3 mm from apex. Root-end cavities were prepared by CO2 laser beam, ultrasonic retrotips, or bur and were filled with amalgam. The teeth were isolated and immersed in basic fuchsin at 36 degrees C for 48 hours. The roots were split longitudinally and examined by a stereomicroscope. Leakage was quantified by linear measurement of dye penetration with the aid of image-analyzing software. Apical leakage in the CO2 laser group was significantly less than in the ultrasonic retrotip and bur groups. The difference between the ultrasonic and bur groups was insignificant. Based on the results of this in vitro study, application of CO2 laser for root-end cavity preparation appears to decrease the apical leakage.
Solvation and ion aggregation of tetraalkylammonium salts in hexamethylphosphoramide as studied by gas solubilities and electron spin resonance (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvation and ion aggregation of tetraalkylammonium salts in hexamethylphosphoramide as studied by gas solubilities and electron spin resonanceCheryl D. StevensonCheryl D. StevensonMore by Cheryl D. Stevenson and Wilson MartirWilson MartirMore by Wilson MartirCite this: J. Phys. Chem. 1978, 82, 10, 1171–1174Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/j100499a018https://doi.org/10.1021/j100499a018research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Estimation of Stress-Strain behavior of polyethylene terephthalate (PET) at different strain rates by Artificial Neural Network under simultaneous stretch scenario (2021)

In this paper, an Artificial Neural Network (ANN) is used to predict the stress-strain behavior of PET at conditions relevant to Stretch Blow Moulding i.e. Large equibiaxial deformation at elevated temperature and high strain rate. The input vectors considered are temperature, strain, and strain rate with a corresponding output parameter of stress. In the present work, a feed-forward back backpropagation algorithm was used to train the ANN. The ANN is able to approximate the relationship between stress and strain at various strain rates &amp; temperatures to a high degree of accuracy for all conditions tested.
Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts (2012)

Cardiovascular hypertrophy is a common feature of hypertension and an important risk factor for heart damage. The regression of cardiovascular hypertrophy is currently considered an important therapeutic target in reducing the omplications of hypertension. The aim of this study was to investigate the inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt (PSPY) with high γ-aminobutyric acid (GABA) content in spontaneously hypertensive rat (SHR) hearts. Six-week-old male SHRs were separated randomly and equally into 4 experimental groups: sterile water, captopril and 2 PSPY groups with different doses (10 and 100%) for 8 weeks. The changes in myocardial architecture and key molecules of the hypertrophy-related pathway in the excised left ventricle from these rats were determined by histopathological analysis, hematoxylin and eosin staining and western blot analysis. Abnormal myocardial architecture and enlarged interstitial spaces observed in the SHRs were significantly decreased in the captopril and PSPY groups compared with the sterile water group. Moreover, the increases in atrial natriuretic peptide, B-type natriuretic peptide, phosphorilated protein kinase Cα and calmodulin-dependent protein kinase II levels in the left ventricle were accompanied by hypertension and increases in phosphorylated extracellular signal-regulated kinase 5 activities with enhanced cardiac hypertrophy. However, the protein levels of the hypertrophic-related pathways were completely reversed by the administration of PSPY. PSPY may repress the activation of ANP and BNP which subsequently inhibit the dephosphorylation of the nuclear factor of activated T-cells, cytoplasmic 3 and ultimately prevent the progression of cardiac hypertrophy.