gebhart/patrepeval huggingface dataset:
The Design of closed loop controllers for wind turbines (2000)

Abstract This article reviews the design of algorithms for wind turbine pitch control and also for generator torque control in the case of variable speed turbines. Some recent and possible future developments are discussed. Although pitch control is used primarily to limit power in high winds, it also has a significant effect on various loads. Particularly as turbines become larger, there is increasing interest in designing controllers to mitigate loads as far as possible. Torque control in variable speed turbines is used primarily to maximize energy capture below rated wind speed and to limit the torque above rated. Once again there are opportunities for designing these controllers so as to mitigate certain loads. In addition to improving the design of the control algorithms, it is also possible to use additional sensors to help the controller to achieve its objectives more effectively. The use of additional actuators in the form of individual pitch controllers for each blade is also discussed. It is important to be able to quantify the benefits of any new controller. Although computer simulations are useful, field trials are also vital. The variability of the real wind means that particular care is needed in the design of the trials. Copyright © 2001 John Wiley &amp; Sons, Ltd.
High-performance control of paralleled three-phase inverters for residential microgrid architectures based on online uninterruptable power systems (2015)

In this paper, a control strategy for the parallel operation of three-phase inverters forming an online uninterruptible power system (UPS) is presented. The UPS system consists of a cluster of paralleled inverters with LC filters directly connected to an AC critical bus and an AC/DC forming a DC bus. The proposed control scheme is performed on two layers: (i) a local layer that contains a “reactive power vs phase” in order to synchronize the phase angle of each inverter and a virtual resistance loop that guarantees equal power sharing among inverters; (ii) a central controller that guarantees synchronization with an external real/fictitious utility, and critical bus voltage restoration. Constant transient and steady-state frequency, active, reactive and harmonic power sharing, and global phase-locked loop resynchronization capability are achieved. Detailed system topology and control architecture are presented in this paper. Also a mathematical model was derived in order to analyze critical parameters effect on system stability. An experimental setup was built in order to validate the proposed control approach under several case-study scenarios. Finally, a conclusion is presented.
The Africanized ‘killer’ bee: biology and public health (1994)

Journal Article The Africanized ‘killer’ bee: biology and public health Get access M.L. WINSTON M.L. WINSTON Department of Biological Sciences, Simon Fraser UniversityBurnaby, Canada Address correspondence to Professor M. L. Winston, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 87, Issue 5, May 1994, Pages 263–267, https://doi.org/10.1093/oxfordjournals.qjmed.a068926 Published: 01 May 1994
Experimental evidence of symmetry breaking of transition-path times (2018)

While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments.
Clustering of Peptide-Loaded MHC Class I Molecules for Endoplasmic Reticulum Export Imaged by Fluorescence Resonance Energy Transfer (2001)

Fluorescence resonance energy transfer between cyan fluorescent protein- and yellow fluorescent protein-tagged MHC class I molecules reports on their spatial organization during assembly and export from the endoplasmic reticulum (ER). A fraction of MHC class I molecules is clustered in the ER at steady state. Contrary to expectations from biochemical models, this fraction is not bound to the TAP. Instead, it appears that MHC class I molecules cluster after peptide loading. This clustering points toward a novel step involved in the selective export of peptide-loaded MHC class I molecules from the ER. Consistent with this model, we detected clusters of wild-type HLA-A2 molecules and of mutant A2-T134K molecules that cannot bind TAP, but HLA-A2 did not detectably cluster with A2-T134K at steady state. Lactacystin treatment disrupted the HLA-A2 clusters, but had no effect on the A2-T134K clusters. However, when cells were fed peptides with high affinity for HLA-A2, mixed clusters containing both HLA-A2 and A2-T134K were detected.
Switched reluctance machine model using inverse inductance characterization (2003)

This paper sets forth a new switched reluctance machine model based on a current-dependent inverse inductance representation of the flux linkage versus current and position characteristic. This form permits a particularly simple mathematical description. Based on this relationship, a complete state model is derived. The resulting model is easy to implement and computationally efficient. In addition, both manual and genetic-algorithm-based methods of parameter identification are set forth. The accuracy of the model is tested via comparison to laboratory measurements of the machine's steady-state voltage and current waveforms as well as torque-speed characteristics. The proposed model is shown to be quite accurate.
Long-Term Coronary Vascular Response to 32 P β-Particle–Emitting Stents in a Canine Model (1999)

(32)P beta-particle-emitting stents have adverse vascular effects at 15 weeks in the canine normal coronary artery model. Vascular brachytherapy with this device causes increased neointimal formation and prominent, dose-dependent lack of healing.
Production of (E) 10-Hydroxy-8-octadecenoic Acid with Lyophilized Microbial Cells (2005)

Lyophilized non-proliferating microbial cells of Pseudomonas sp. 42A2 showed their ability to catalyze the bioconversion of oleic acid into (E)-10-hydroxy-8-octadecenoic acid (MHOD) and (E)- 7,10-dihydroxy-8-octadecenoic acid (DHOD). The reaction conditions were optimized in order to produce the maximum amount of MHOD. At 30°C and using phosphate buffer (0.1 M and pH=8), an initial substrate concentration of 10 mg mL� 1 and a cell concentration of 8 mg mL� 1 , practically all the oleic acid in the medium was biotransformed within 42 h, with hardly any DHOD produced (1.4 mg mL� 1 ).
Recent clinical trials of iodixanol. (2003)

In patients with well-preserved renal function, the choice of contrast agent appears to have little impact on the development of contrast-induced nephropathy (CIN). However, in patients with underlying renal insufficiency and diabetes mellitus, it has been shown that the use of low-osmolar media is associated with a lower incidence of CIN compared with high-osmolar agents. Previously, it was unknown whether further benefit would be derived from the use of iso-osmolar contrast media. Recent studies, including Nephrotoxicity in High-Risk Patients Study of Iso-osmolar and Low-Osmolar Nonionic Contrast Media (NEPHRIC), have shown a reduction in the incidence of CIN with the iso-osmolar contrast agent iodixanol compared with low-osmolar agents in patients with renal insufficiency and diabetes. The peak rise in serum creatinine was significantly reduced with iodixanol (0.13 mg/dL vs 0.55 mg/dL, P <.001). The incidence of CIN, defined as a peak rise > 0.5 mg/dL, was decreased from 26% to 3%, P <.0002 when iodixanol was used. An ongoing, multicenter, prospective, double-blind, randomized study (Visipaque Angiography/Interventions with Laboratory Outcomes for Renal Insufficiency [VALOR]) is evaluating the potential benefit of iodixanol in reducing CIN in patients with preexisting renal impairment. Accumulating evidence suggests that the use of iso-osmolar contrast agents in conjunction with other proven measures, especially adequate intravenous hydration and contrast dosage limitation, can reduce the morbidity and mortality associated with CIN. These measures have the potential for a significant reduction in health care costs.
Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice (2020)

Abstract Background Vaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication and clinical trials have targeted zygote antigen Pfs25 for decades. We reported that a Pfs25 protein-protein conjugate vaccine formulated in alum adjuvant induced significant serum functional activity in both US and Malian adults. However, antibody titers declined rapidly, and transmission-reducing activity required four vaccine doses. Functional immunogenicity and durability must be improved before advancing TBV further in clinical development. We hypothesized that the pre-fertilization protein Pfs230 alone or in combination with Pfs25 would improve functional activity. Methods Transmission-blocking vaccine candidates based on gamete antigen Pfs230 or Pfs25 were conjugated with Exoprotein A, formulated in Alhydrogel ®, and administered to mice, rhesus macaques, and humans. Antibody titers were measured by ELISA and transmission-reducing activity was assess by the Standard Membrane Feeding Assay. Results Pfs25-EPA/Alhydrogel ® and Pfs230D1-EPA/Alhydrogel ® induced similar serum functional activity in mice, but Pfs230D1-EPA induced significantly greater activity in rhesus monkeys that was enhanced by complement. In U.S. adults, two vaccine doses induced complement-dependent activity in 4 of 5 Pfs230D1-EPA/Alhydrogel® recipients but no significant activity in five Pfs25-EPA recipients, and combination with Pfs25-EPA did not increase activity over Pfs230D1-EPA alone. Conclusion The complement-dependent functional immunogenicity of Pfs230D1-EPA represents a significant improvement over Pfs25-EPA. The rhesus model is more predictive of the functional human immune response to Pfs230D1 than is the mouse model. Trial Registration ClinicalTrials.gov NCT02334462 Funding This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Millimeter-wave and terahertz imaging techniques (2013)

This thesis presents the development and assessment of imaging techniques in the millimeterwave (mmW) and terahertz frequency bands. In the first part of the thesis, the development of a 94 GHz passive screener based on a total-power radiometer (TPR) with mechanical beamscanning is presented. Several images have been acquired with the TPR screener demonstrator, either in indoor and outdoor environments, serving as a testbed to acquire the know-how required to perform the research presented in the following parts of the thesis. In the second part of the thesis, a theoretical research on the performance of near-field passive screeners is described. This part stands out the tradeoff between spatial and radiometric resolutions taking into account the image distortion produced by placing the scenario in the near-field range of the radiometer array. In addition, the impact of the decorrelation effect in the image has been also studied simulating the reconstruction technique of a synthetic aperture radiometer. Guidelines to choose the proper radiometer depending on the application, the scenario, the acquisition speed and the tolerated image distortion are given in this part. In the third part of the thesis, the development of a correlation technique with optical processing applicable to millimeter-wave interferometric radiometers is described. The technique is capable of correlating wide-bandwidth signals in the optical domain with no loss of radiometric sensitivity. The theoretical development of the method as well as measurements validating the suitability to correlate radiometric signals are presented in this part. In the final part of the thesis, the frequency band of the imaging problem is increased to frequencies beyond 100 GHz, covering the THz band. In this case the research is centered in tomographic techniques that include spectral information of the samples in the reconstructed images. The tomographic algorithm can provide detection and identification of chemical compounds that present a certain spectral footprint in the THz frequency band.
Effect of particle size and surface area of corn on pig performance and nutrient digestibility (1984)

Two feeding trials and two digestion trials were conducted to evaluate the effects of particle size and surface area of corn on the performance and nutrient digestibility of weaning and finishing pigs. The effects of particle size on production rate and grinding efficiency also were evaluated. Production rate and grinding efficiency decreased as particle size decreased. Average daily gain was not influenced by particle size. Feed intake tended to decrease as particle size decreased with the lowest feed intake on the fine partice size diet. Feed efficiency tended to improve as particle size decreased. The incidence of ulceration in the esophageal region of the stomach of finishing pigs increased as particle size of diet decreased. Digestibility of dry matter, nitrogen and energy improved as particle size decreased or surface area increased with diets for both weaning and finishing pigs.; Swine Day, Manhattan, KS, November 15, 1984
Silicon Strip Detectors for Scanned Multi-Slit X-Ray Imaging (2003)

Digital imaging systems for medical applications must bebased upon highly efficient detectors to ensure low patientdose. This is particularly important in screening mammographybecause of the large number healthy women that is examined. Amammography system must also provide high spatial and contrastresolution. Different approaches are compared in this thesis,and it is argued that a system based on photon countingdetectors in a scanned multi-slit geometry provides aperformance superior to established technologies. The system is realized using silicon strip detectorsirradiated at a small angle relative to the wafer surface,thereby offering large absorption depth. A linear pixelarray isscanned across the breast to obtain the complete image.Pulse-processing electronics rejecting all detector andelectronics noise count the number of photons that aredetected, forming the pixel values of the image. Optimization of the detector design is discussed in detail.The detector has been carefully simulated to investigate chargemotion and signal formation after photoninteraction. Based onthese simulations, the impact of the detector characteristicson the image quality has been evaluated. Detectors have been manufactured and evaluated both assingle components and as part of experimental imaging devicesincluding custom readout electronics. Presented in this thesisare the measured detector characteristics including a verifi-cation of charge collection efficiency and confirmation thatthe quantum efficiency is 90% for a typical mammographyspectrum. Modulation transfer functions and noise power spectrawere recorded and the detective quantum efficiency calculated.A prototype mammography system was also assembled and themodulation transfer function recorded. The interpretation ofthe modulation transfer function and detective quantumefficiency is discussed for digital systems in general and fora scanned multi-slit system in particular. &lt;b&gt;Keywords:&lt;/b&gt;x-ray, imaging, silicon, detector, digital,mammography, scanning, photon counting.
Personal robot assisting transportation to support active human life &#x2014; Human-following method based on model predictive control for adjacency without collision (2015)

An aging society exists throughout the entire world. In order to support the aging society, service robots that are able to improve our comfortable lifestyle and increase longevity have been developed. However, excessive and premature robot support may cause not only the deterioration of our physical ability but also shortening of the period of well-being. In our research group, a personal robot that can carry baggage and automatically follow a human being was developed to overcome the above problem. The people that use this personal robot will be able to walk outside with empty hands, even after shopping, thus contributing to their health management. In this paper, the past prototypes of the personal robot are discussed, and the new robot is presented. Also, a human-following method based on model predictive control is proposed to realize the contradicting requirements of both shortening the relative distance between the owner and the robot and ensuring no collision. The effectiveness of the proposed approach is verified by numerical simulation of the prototype robot.
Supplementary Data from Long-term Follow-up and Correlative Analysis of Two Phase II Trials of Rituximab and Lenalidomide Followed by Continuous Lenalidomide in Untreated and Relapsed/Refractory Indolent Lymphoma (2023)

&lt;p&gt;Supplemental Table 4&lt;/p&gt;
Evidence for a Critical Amorphization Thickness Limit of Ga+ Ion Bombardment in Si (2007)

Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
On the Accessibility of Adaptive Phenotypes of a Bacterial Metabolic Network (2009)

The mechanisms by which adaptive phenotypes spread within an evolving population after their emergence are understood fairly well. Much less is known about the factors that influence the evolutionary accessibility of such phenotypes, a pre-requisite for their emergence in a population. Here, we investigate the influence of environmental quality on the accessibility of adaptive phenotypes of Escherichia coli's central metabolic network. We used an established flux-balance model of metabolism as the basis for a genotype-phenotype map (GPM). We quantified the effects of seven qualitatively different environments (corresponding to both carbohydrate and gluconeogenic metabolic substrates) on the structure of this GPM. We found that the GPM has a more rugged structure in qualitatively poorer environments, suggesting that adaptive phenotypes could be intrinsically less accessible in such environments. Nevertheless, on average approximately 74% of the genotype can be altered by neutral drift, in the environment where the GPM is most rugged; this could allow evolving populations to circumvent such ruggedness. Furthermore, we found that the normalized mutual information (NMI) of genotype differences relative to phenotype differences, which measures the GPM's capacity to transmit information about phenotype differences, is positively correlated with (simulation-based) estimates of the accessibility of adaptive phenotypes in different environments. These results are consistent with the predictions of a simple analytic theory that makes explicit the relationship between the NMI and the speed of adaptation. The results suggest an intuitive information-theoretic principle for evolutionary adaptation; adaptation could be faster in environments where the GPM has a greater capacity to transmit information about phenotype differences. More generally, our results provide insight into fundamental environment-specific differences in the accessibility of adaptive phenotypes, and they suggest opportunities for research at the interface between information theory and evolutionary biology.
Recognition of music types (2002)

This paper describes a music type recognition system that can be used to index and search in multimedia databases. A new approach to temporal structure modeling is supposed. The so called ETM-NN (explicit time modelling with neural network) method uses abstraction of acoustical events to the hidden units of a neural network. This new set of abstract features representing temporal structures, can be then learned via a traditional neural networks to discriminate between different types of music. The experiments show that this method outperforms HMMs significantly.
ChemInform Abstract: STEREOSELECTIVE SYNTHESIS OF A TRICYCLIC PRECURSOR OF 18‐NOR‐8β‐METHYLESTRADIOL (1976)

Abstract Das ungesättigte (‐)‐Ketodiketal (I) wird durch eine stereoselektiv verlaufende LiNH 2 ‐Reduktion in NH 3 bei ‐50°C und eine Umketalisierung des entstehenden gesättigten Ketodiketals (II) mit Cyclopentanon in Gegenwart von p‐Toluolsulfonsäure bei 20°C in das Diketoketal (III) übergeführt.
Joint Optimization of IT, IP and WDM Layers: From Theory to Practice (2020)

Softwarization of carrier networks is an unstoppable trend, driven by the possibility of instantiating Virtual Network Functions (VNFs) in carrier-owned data centers in their points-of-presence. In optical networks, VNF placement decisions are now intrinsically tight to IP and WDM resource allocations, e.g. in the metro, moving a VNF to a different central office changes the IP flows to carry, which then impacts the optical circuit footprint. In this paper, we review the efforts for a joint or cooperative optimization of the IT, IP and optical resources, both from the offline capacity planning and the online resource allocation points of view. The paper covers both theoretical results and practical implementation initiatives. Among them, we further elaborate on the Metro-Haul project approach, that proposes a common simulation framework for algorithm development and testing, which allows the application of those algorithms in demonstration prototypes.