gebhart/patrepeval huggingface dataset:
Evaluation of Chromosome Microarray Analysis in a Large Cohort of Females with Autism Spectrum Disorders: A Single Center Italian Study (2020)

Autism spectrum disorders (ASD) encompass a heterogeneous group of neurodevelopmental disorders resulting from the complex interaction between genetic and environmental factors. Thanks to the chromosome microarray analysis (CMA) in clinical practice, the accurate identification and characterization of submicroscopic deletions/duplications (copy number variants, CNVs) associated with ASD was made possible. However, the widely acknowledged excess of males on the autism spectrum reflects on a paucity of CMA studies specifically focused on females with ASD (f-ASD). In this framework, we aim to evaluate the frequency of causative CNVs in a single-center cohort of idiopathic f-ASD. Among the 90 f-ASD analyzed, we found 20 patients with one or two potentially pathogenic CNVs, including those previously associated with ASD (located at 16<i>p</i>13.2 16<i>p</i>11.2, 15<i>q</i>11.2, and 22<i>q</i>11.21 regions). An exploratory genotype/phenotype analysis revealed that the f-ASD with causative CNVs had statistically significantly lower restrictive and repetitive behaviors than those without CNVs or with non-causative CNVs. Future work should focus on further understanding of f-ASD genetic underpinnings, taking advantage of next-generation sequencing technologies, with the ultimate goal of contributing to precision medicine in ASD.
BONE INGROWTH IN RETRIEVED POROUS COATED ACETABULAR COMPONENTS (2017)

Introduction Cementless acetabular components are commonly used in primary and revision total hip arthroplasty, and most designs have been successful despite differences in the porous coating structure. Components with 2D titanium fiber mesh coating (FM) have demonstrated high survivorships up to 97% at 20 years1. 3D tantalum porous coatings (TPC) have been introduced in an attempt to improve osseointegration and therefore implant fixation. Animal models showed good results with this new material one year after implantation2, and clinical and radiographic studies have demonstrated satisfactory outcomes3. However, few retrieval studies exist evaluating in vivo bone ingrowth into TPC components in humans. We compared bone ingrowth between well-fixed FM and TPC retrieved acetabular shells using backscatter scanning electron microscopy (BSEM).

Methods 16 retrieved, well-fixed, porous coated acetabulum components, 8 FM matched to 8 TPC by gender, BMI and age, all revised for reasons other than loosening and infection, were identified from our retrieval archive (Fig. 1). The mean time in-situ was 42 months for TPC and 172 for FM components. Components were cleaned, dehydrated, and embedded in PMMA. They were then sectioned, polished, and examined using BSEM. Cross-sectional slices were analyzed for percent bone ingrowth and percent depth of bone ingrowth (Fig. 2). Analysis was done using manual segmentation and grayscale thresholding to calculate areas of bone, metal, and void space. Percent bone ingrowth was determined by assessing the area of bone compared to the void space that had potential for bone ingrowth.

Results The average bone ingrowth was 19.2% for the eight FM components and 6.9% for the eight TPC components. Bone ingrowth in the FM components was quite variable, ranging from as little as 2.3% to as much as 71.6%. Conversely, the amount of bone ingrowth seen in the TCP acetabular cups was less variable, ranging from 0.4% to 13%. By design, TPC cups were more porous; the retrieved TPC cups had ∼65–75% porosity (area void space divided by total area of void space plus metal), while the retrieved FM cups had ∼40–50% porosity. No relation was found between bone ingrowth measured in the retrievals at the length of time that they had been implanted.

Discussion The TPC retrievals were well-fixed at revision surgery, despite the small percent of the coating that had bone ingrowth. Other factors, such as high coefficient of friction, leading to effective initial fixation and sufficient bone ongrowth rather than ingrowth, may impact clinical performance. A previous study of post-mortem, well-fixed retrieved FM cups found 12 ±8% bone area ingrowth4, similar to our findings. Ongoing retrieval analysis will provide further insight into possible regional trends and material ingrowth differences.
Modulation of collagen and fibronectin synthesis in fibroblasts by normal and malignant cells (1992)

The influence of various normal and malignant human cells on the level of collagen synthesis by human fibroblasts was tested in coculture. As revealed by immunoperoxidase staining, in cocultures with breast adenocarcinoma cells (MCF7, SA52, T47D) fibroblasts synthesized collagen while tumor cells did not. Fibroblasts displayed increased collagen production without change in the overall protein synthesis. Several other types of cells derived from normal human tissues (keratinocytes, normal mammary cells) or from fibrosarcoma, melanoma, cervical carcinoma, choriocarcinoma, or other breast adenocarcinoma (SW613, MDA, BT20) did not affect collagen synthesis of fibroblasts. Although to a lesser extent, this stimulating effect was reproduced by using the conditioned medium (CM) of the active cells but not with CM of the other cell types. A slight stimulation was also obtained when tumoral MCF7 cells and fibroblasts shared the same medium but were physically separated, suggesting that close contact was required for optimal stimulation of collagen synthesis. The collagen synthesis stimulating activity was not related to a modification of fibroblast proliferation rate. The production of collagen types I, III, and VI and fibronectin were increased in cocultures of fibroblasts with MCF7 cells. The increased synthesis of collagen types I and III and fibronectin was paralleled by similar changes in the steady-state level of their mRNAs. On the contrary, the increased production of collagen type VI appeared regulated at a post-transcriptional level.
Application of Normal Mode Expansion to Accoustic Emission Waves in Finite Plates (1996)

Brief Notes Application of Normal Mode Expansion to Accoustic Emission Waves in Finite Plates M. R. Gorman, M. R. Gorman Department of Physics, University of Denver, Denver, CO 80208-0177 Search for other works by this author on: This Site PubMed Google Scholar W. H. Prosser W. H. Prosser Nondestructive Measurement Science Brance, NASA LaRC, Hampton, VA 23681-0001 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information M. R. Gorman Department of Physics, University of Denver, Denver, CO 80208-0177 W. H. Prosser Nondestructive Measurement Science Brance, NASA LaRC, Hampton, VA 23681-0001 J. Appl. Mech. Jun 1996, 63(2): 555-557 (3 pages) https://doi.org/10.1115/1.2788905 Published Online: June 1, 1996 Article history Received: May 1, 1995 Accepted: May 1, 1995 Online: October 26, 2007
Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes (2016)

When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, but the underlying mechanism that controls antigen restriction is poorly understood. Here we describe the role of neurons in sensing and restricting antigen flow in lymph nodes. The antigen keyhole-limpet hemocyanin (KLH) injected into the mouse hind paw flows from the popliteal lymph node to the sciatic lymph node, continuing through the upper lymphatics to reach the systemic circulation. Re-exposure to KLH in previously immunized mice leads to decreased flow from the popliteal to the sciatic lymph node as compared with naïve mice. Administering bupivacaine into the lymph node region restores antigen flow in immunized animals. In contrast, neural activation using magnetic stimulation significantly decreases antigen trafficking in naïve animals as compared with sham controls. Ablating Na<sub>V</sub>1.8 + sensory neurons significantly reduces antigen restriction in immunized mice. Genetic deletion of FcγRI/FcεRI also reverses the antigen restriction. Colocalization of PGP9.5-expressing neurons, FcγRI receptors and labeled antigen occurs at the antigen challenge site. Together, these studies reveal that neuronal circuits modulate antigen trafficking through a pathway that requires Na<sub>V</sub>1.8 and FcγR.
ChemInform Abstract: Σ AND Π EFFECTS ON THE COPPER(II)/COPPER(I) REDOX COUPLE POTENTIAL IN TETRAAZAMACROCYCLIC COMPLEXES (1982)

Abstract Elektrochemische Untersuchungen an den makrocyclischen Cu(II)‐ Komplexen (I)‐(III), die sich alle einem reversiblen Einelektronen‐Reduktions‐ prozeß an einer Hg‐Elektrode in Methanol (0.l M Et 4 NBF 4 ) unterwerfen, werden durchgeführt und Halbsttifenpotentiale mitgeteilt.
NMR and X-Ray Investigation of the Phase Behavior of Phosphatidylethanolamines (1985)

Abstract The second moments of the proton magnetic resonance lines of DPPE and DMPE, below the main phase transition, vary within a similar range as those of the corresponding phosphatidylcholines. In contrast to the sharp “subtransition” between L[sgrave]’ and Lβ’ phase, observed in the latter class of lipids, both DMPE and DPPE exhibit a broad transition (∼15 K width) to a less mobile state at lower temperatures ∼ -20[ddot]C. The second moment of the hydrocarbon chain resonance line in this state is between the value observed in the L[sgrave]’ phase of DPPC and the higher value of the rigid lattice. In addition to these phenomena a time-dependent transition from the gel phase to a rigid crystalline state is observed in DMPE, with rigid lattice values for the second moments. This behaviour is presumably analogous to that found for DLPE. The X-ray diffraction patterns indicate that a hexagonal lattice exists for the hydrocarbon chains throughout the entire observed temperature range below the main transition, with increasing density of chain packing towards lower temperatures. In the low temperature state, the corresponding reflection is appreciably broadened, due to the reduced long-range order. In addition, the lamellar spacing is drastically reduced (∼10%) resulting from the loss of interlamellar water. The hydrocarbon chains are shown to remain untilted.
The adipokine SAA3 is induced by interleukin‐1β in mouse adipocytes (2008)

Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1beta was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1beta in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1beta significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1beta-induced SAA3 expression was mediated by nuclear factor-kappaB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1beta.
Implications of Cardiovascular Disease for Prostate Cancer Patients Receiving Androgen-Signaling Inhibitors (2020)

Androgen-deprivation therapy (ADT) — the critical initial step in the management of patients with advanced prostate cancer — is associated with a range
A rare cause of GI bleeding in a 56-year-old man (2016)

A 56-year-old man, with a known history of diabetes for 1 year, presented with a 5-day history of melena that was associated with one episode of haematemesis. One month prior, he had completed a course of oral amoxicillin for a dental infection that occurred after a tooth extraction. The only other significant past medical problem was hypertension for 10 years. Physical examination only showed pallor and abdominal examination was normal. Laboratory investigations revealed haemoglobin level of 8.4 g/dL and HbA1C of 7.8%. His upper GI endoscopy showed a diffuse irregular friable exudative ulcerative lesion involving the gastric fundus (figure 1). Endoscopic ultrasonography (EUS) demonstrated disrupted gastric wall layers with wall thickening of 5.1 mm and regional lymph nodes (figure …
Distribution and Categorization of Echocardiographic Measurements in Relation to Reference Limits (1997)

Using a large community-based study sample, we propose a classification scheme that provides a standardized and validated framework for partitioning echocardiographic measurements. If adopted, the categorization scheme should promote uniformity in describing measurements among echocardiographic laboratories and enhance the comprehensibility of measurements to clinicians.
X-Band Sheet Beam Klystron (XSBK) (2009)

The sheet beam klystron (SBK) is characterized by a large drift tube, which allows the use of high beam current at a low voltage, resulting in low beam current density, high efficiency and the possibility of PPM focusing. CPI has designed, manufactured and is currently testing an X-Band SBK capable of 5 MW peak, 20 kW average output power. This paper discusses the general design, manufacturing and performance to date of CPI's X-Band SBK.
A new method for on‐line controller tuning (1982)

Abstract A new method for tuning controllers on‐line has been developed based on a single experimental test, a step change in controller set point. The set‐point response data and analytical formulae are used to calculate model parameters for a first‐order plus time delay transfer function. Controller settings can then be calculated using the model parameters and standard controller tuning relations. Simulation results demonstrate that the new method provides good initial values for PID controller settings despite gross modeling errors and unanticipated load disturbances that may occur during the experimental test.
TATA box-dependent protein-DNA interactions are detected on heat shock and histone gene promoters in nuclear extracts derived from Drosophila melanogaster embryos. (1988)

We monitored protein-DNA interactions that occur on the hsp26, hsp70, histone H3, and histone H4 promoters in nuclear extracts derived from frozen Drosophila melanogaster embryos. All four of these promoters were found to be transcribed in vitro at comparable levels by extracts from both heat-shocked and non-heat-shocked embryos. Factors were detected in both types of extracts that block exonuclease digestion from a downstream site at ca. +35 and -20 base pairs from the start of transcription of all four of these promoters. In addition, factors in extracts from heat-shocked embryos blocked exonuclease digestion at sites flanking the heat shock consensus sequences of hsp26 and hsp70. Competition experiments indicated that common factors cause the +35 and -20 barriers on all four promoters in both extracts. The formation of the barriers at +35 and -20 required a TATA box but did not appear to require specific sequences downstream of +7. We suggest that the factors responsible for the +35 and -20 barriers are components whose association with the promoter precedes transcriptional activation.
Total Moisture Analysis of Salts by Dissolution (2021)

This report discusses recent efforts within TA-48 in developing a robust, defensible, and straightforward procedure for determining the moisture content of alkali and alkaline metal halide salts utilizing a total dissolution Karl-Fischer titration method. Utilizing statistical analysis of blank and dissolved salt samples, we determine a (3 sigma) detection limit of 67 micrograms H2O/g salt, and a (10 sigma) quantification limit of 160 micrograms H2O/g salt. Several salts are analyzed, and suggestions for future efforts are given.
Thermodynamics of high‐temperature aluminum, zirconium, and yttrium hydroxide and oxyhydroxide vapor species (2020)

Abstract Thermodynamic parameters are reported for gaseous hydroxides and oxyhydroxides of Al, Zr, and Y. The structures and vibrational frequencies are calculated using density functional theory with the B3LYP functional. This yields entropies at 298.15 K and heat capacities. The enthalpies are calculated from appropriate reactions and the CCSD(T) (Coupled Cluster, Singles, Doubles, and perturbative Triples) approach. The hydroxide groups are treated as hindered rotors for all species. The results are compared to the limited experimental and theoretical calculations for these species. Finally, the data are put into a database for a free‐energy minimizer and the vapor pressures for each species are compared.
Cholecystectomy and colorectal cancer. (1983)

Les implications d'une association causale refletent : 1) les consequences biologiques possibles de l'ablation de la vesicule biliaire sur la microecologie et le metabolisme des acides biliaires primitifs et secondaires et des sterols neutres dans l'intestin ou 2) ou le fait que l'evolution naturelle des calculs vesiculaires de ce cholesterol et de la cholecystopathie est influence par des facteurs alimentaires exogenes qui sont aussi indiques dans l'evolution naturelle du cancer du colon
Prediction of the thermal comfort indices using improved support vector machine classifiers and nonlinear kernel functions (2014)

A new prediction method for thermal comfort indices is introduced. This method of prediction titled ‘support vector machine (SVM)’ uses learning as a process to emulate human intelligence. In this paper, more adequate nonlinear kernels have been used and the SVM has been improved to predict the thermal comfort indices accurately. In this study, we focus mainly on supervised learning machine where an instructor provides the output samples during the learning phase. Different sets of representative experimental factors, such as air temperature, mean radiant temperature, relative humidity, air velocity, metabolism and clothing value that affect a person’s thermal balance were used for training the SVM machine. The results show the best correlation between SVM predicted values with a polynomial kernel of the second order and those obtained from conventional thermal comfort, such as the Fanger model and the ‘2-Node’ model.
Advances in lentil production through heterosis: Evaluating generations and breeding systems (2022)

Heterosis is defined as increased performance of the F1 hybrid relative to its parents. In the current study, a cohort of populations and parents were created to evaluate and understand heterosis across generations (i.e., F1 to F3) in lentil, a self-pollinated annual diploid (2n = 2× = 14) crop species. Lentil plants were evaluated for heterotic traits in terms of plant height, biomass fresh weight, seed number, yield per plant and 100 grain weight. A total of 47 selected lentil genotypes were cross hybridized to generate 72 F1 hybrids. The F1 hybrids from the top five crosses exhibited between 31%-62% heterosis for seed number with reference to the better parent. The five best performing heterotic crosses were selected with a negative control for evaluation at the subsequent F2 generation and only the tails of the distribution taken forward to be assessed in the F3 generation as a sub selection. Overall, heterosis decreases across the subsequent generations for all traits studied. However, some individual genotypes were identified at the F2 and sub-selected F3 generations with higher levels of heterosis than the best F1 mean value (hybrid mimics). The phenotypic data for the selected F2 and sub selected F3 hybrids were analysed, and the study suggested that 100 grain weight was the biggest driver of yield followed by seed number. A genetic diversity analysis of all the F1 parents failed to correlate genetic distance and divergence among parents with heterotic F1's. Therefore, genetic distance was not a key factor to determine heterosis in lentil. The study highlights the challenges associated with different breeding systems for heterosis (i.e., F1 hybrid-based breeding systems and/or via hybrid mimics) but demonstrates the potential significant gains that could be achieved in lentil productivity.
3P1-D01 Dental Patient Robot : Reappearance of the condition change in dental therapy(Medical Robotics and Mechatronics (2)) (2014)

Recently, problems of low master of the techniques by students of department of Dentistry and trainees due to decreasing numbers of patients and increasing numbers of dentists are raised. To address the problems a dental patient robot that operates in a similar manner to an actual patient was developed. It is not so often that a patient fall into an emergency condition while s/he is being treated. Therefore, their knowledge is only knowledge acquired through books. They do not work through or they do not know what is happening when they see it. Hence, we developed a hand mechanism which shows a state in this scholarship. This system will enable practices in managing critical conditions. It possible to practical. We aimed to reproduce the condition which happens at the time of medical treatment by developing the hand mechanism which shows a state this year.
Threat-adaptive security policy (2002)

Secure systems have traditionally paid little attention to performance. This is because current secure systems apply a uniform and statically decided upon security policy to each user and do not associate an individualized level of trust with each user at run-time. This paper describes a new framework of threat and performance driven security. A threat-adaptive model which enforces a dynamic and individualized security policy mechanism, with a trust state machine capturing the different security levels is proposed. This paper discusses a threat-adaptive firewall designed for an EC application, which adaptively varies the security constraints for each user, thereby improving the system performance.
Hierarchical TiO2 spherical nanostructures with tunable pore size, pore volume, and specific surface area: facile preparation and high-photocatalytic performance (2012)

Anatase TiO2 hierarchical nanostructural microspheres with tunable pore size, pore volume, and specific surface area were prepared by a facile two-step method of electrospray and hydrothermal treatment. Compared to the calcination, the hydrothermal treatment can transfer the electrosprayed TiO2 microspheres to porous hierarchical nanostructures. Adding ammonia in the hydrothermal process has a great effect on the pore structure of TiO2 microspheres. The hydrothermal-treated samples with >2.0 ml ammonia being added are composed of both big and small nanocrystals. Some of the large nanocrystals grow in the [001] direction and contain step-like {101} surfaces. The large nanoparticles are formed through the combination of small particles by dehydration, which finally leads to the change of TiO2 microspheres from mesoporous to large-porous structure. The effects of the specific surface area, the pore volume, and the pore size on the photocatalytic activity are studied. It is considered that the pores on the surface layer of TiO2 microspheres are like a door that can control the diffusion of reactants between the outside and the inside. If the size of pores on the surface is big enough to allow the fast diffusion of reactants, the photocatalytic activity will increase with the increase of specific surface area and pore volume. In addition, further calcination on the TiO2 spheres after hydrothermal treatment can increase the photocatalytic activity, which is better than the commercial P25.