gebhart/patrepeval huggingface dataset:
Dendritic Cell Immunotherapy for Melanoma (1999)

Melanoma is a particularly aggressive malignant tumour of the skin that is influenced by genetic, environmental and physiological elements. Since current therapy for melanoma is limited and associated with high toxicity and side effects, development of alternative approaches is imperative. The importance of dendritic cells (DCs) in immunity against tumours is now well established. DC immunotherapy for melanoma is possible but must be considered in terms of effectiveness and clinical viability. The source of DCs to be used in adoptive therapy as well as the nature and method of delivery of the priming antigen are important factors. The most suitable DC appears to be cells derived by culture from hemopoietic progenitor cells (HPC) in bone marrow or DC progenitors in peripheral blood. Generation of an effective anti-tumour immune response will be dependent upon the presentation of multiple melanoma-specific antigens by both major histocompatibility complex (MHC) class I and class II molecules and stimulation of both tumour-specific cytotoxic T lymphocytes (Tc) and T helper type 1 (Thl) cells. Different techniques for delivery of the priming antigen offer different advantages. DCs can be pulsed with peptide, protein or tumour cell lysate, transfected with viral vectors or naked nucleic acid and tumour/DC hybridomas can also be generated. Repeated antigen administration into neighbouring lymph nodes appears to be the most effective method for promoting a systemic anti-tumour response. Adjuvant therapies can also enhance immune responses and lead to total tumour clearance. The importance of DC immunotherapy in clinically different stages of disease will also be an important consideration.
The Treatment and Prevention of Diabetic Ketoacidosis in Children and Adolescents With Type I Diabetes Mellitus (1999)

There remain a number of important controversies in the management of pediatric DKA. From the sodium content of the hydrational fluid to the rate of fluid administration that is best able to reverse the hyperosmolar dehydration attendant with DKA with minimal morbidity and mortality, there is no universal agreement on how patients with this devastating metabolic disturbance should be treated. It is still unclear what promotes or protects patients from neurologic insult during DKA reversal. It is appropriate to begin to develop a national approach to eradicating DKA. This would require widespread public and professional education programs aimed at detecting new-onset type I patients prior to the onset of DKA. It would involve promoting diabetes screening programs aimed at detecting patients before the onset of symptomatic disease, and these would most appropriately be centered in the pediatrician's office. In the known patient, DKA still occurs as the result of intercurrent illness and nonadherence to the diabetes regimen due to patient or family chaos and dysfunction. Clearly, more strategies are needed to address these psychological and family patterns and the fact that many tenuous families have insufficient access to appropriate medical care. Those caring for children and adolescents must do all they can to prevent DKA and to treat it optimally to avert the toll this metabolic aberration takes on the pediatric diabetes population.
Pharmacological Exploitation of an Off-Target Antibacterial Effect of the Cyclooxygenase-2 Inhibitor Celecoxib against Francisella tularensis (2009)

Francisella tularensis, a bacterium which causes tularemia in humans, is classified as a CDC category A bioterrorism agent. In this study, we demonstrate that celecoxib, an anti-inflammatory cyclooxygenase-2 inhibitor in clinical use, exhibits activity against a type A strain of F. tularensis (Schu S4), the live vaccine strain of F. tularensis (a type B strain), and F. novicida ("F. tularensis subsp. novicida") directly in growth medium. This bacterial killing, however, was not noted with rofecoxib, despite its higher potency than that of celecoxib in inhibiting cyclooxygenase-2. The unique ability of celecoxib to inhibit the proliferation of F. tularensis could be pharmacologically exploited to develop novel anti-Francisella therapeutic agents, of which the proof of principle is demonstrated by compound 20, a celecoxib derivative identified through the screening of a celecoxib-based focused compound library. Compound 20 inhibited the intracellular proliferation of Francisella in macrophages without causing appreciable toxicity to these host cells. Together, these data support the translational potential of compound 20 for the further development of novel, potent anti-Francisella agents.
HVM LPP EUV Source System Development Status (2010)

Laser produced plasma (LPP) EUV systems have been considered as a viable and scalable approach for the EUV scanners at sub-32nm and beyond nodes on the ITRS roadmap. High EUV power and reduction of chamber contaminations inside EUV vacuum chambers or to EUV scanner optics are two main concerns for the LPP EUV source system development. In this paper, a review of Cymer LPP EUV development progress will be provided along with productization status for LPP EUV sources with performance goals targeted to meet specific requirements from leading scanner manufacturers. The latest results on high EUV power generation, debris mitigation and clean transmission of EUV light through the intermediate focus will be described. Finally, a development roadmap to achieve high LPP EUV source power will be illustrated.
[Identification physico-chemical properties and immunochemical characteristic of prostate specific antigen and its complexes with protease inhibitors]. (1997)

The study of the PSA complexes with the protease inhibitors has confirmed the opinion of possible existence the complexes of the PSA with a2-macroglobulins and a1-antihymotripsines in blood serum. The immunoenzyme analysis of the PSA and its complexes has made it possible to establish the normal level of the PSA corresponding complexes in donors blood serum. There are reasons to suppose, that the quantitative analysis of the PSA and its complexes with the protease inhibitors can be used for the early diagnosis of PC and its differential diagnosis with the prostate benign hyperplasia. In our opinion, the effect of the complex approach can be more informative than the ordinary PSA detection.
Delay-Tolerant Online Convex Optimization: Unified Analysis and Adaptive-Gradient Algorithms (2016)

We present a unified, black-box-style method for developing and analyzing online convex optimization (OCO) algorithms for full-information online learning in delayed-feedback environments. Our new, simplified analysis enables us to substantially improve upon previous work and to solve a number of open problems from the literature. Specifically, we develop and analyze asynchronous AdaGrad-style algorithms from the Follow-the-Regularized-Leader (FTRL) and Mirror-Descent family that, unlike previous works, can handle projections and adapt both to the gradients and the delays, without relying on either strong convexity or smoothness of the objective function, or data sparsity. Our unified framework builds on a natural reduction from delayed-feedback to standard (non-delayed) online learning. This reduction, together with recent unification results for OCO algorithms, allows us to analyze the regret of generic FTRL and Mirror-Descent algorithms in the delayed-feedback setting in a unified manner using standard proof techniques. In addition, the reduction is exact and can be used to obtain both upper and lower bounds on the regret in the delayed-feedback setting.
An Experimental Convective Heat Transfer Investigation Around a Film-Cooled Gas Turbine Blade (1990)

The present paper deals with an experimental convective heat transfer investigation around a film-cooled, high-pressure gas turbine rotor blade mounted in a stationary, linear cascade arrangement. The measurements were performed in the von Karman Institute Isentropic Light Piston Compression Tube facility. The test blade was made of Macor glass ceramic and was instrumented with thin film gages. The coolant flow was ejected simultaneously through the leading edge (three rows of holes), the suction side (two rows of holes), and the pressure side (one row of holes). The effects of overall mass weight ratio, coolant to free-stream temperature ratio, and free-stream turbulence were successively investigated.
Transmural action potential and ionic current remodeling in ventricles of failing canine hearts (2002)

Heart failure (HF) produces important alterations in currents underlying cardiac repolarization, but the transmural distribution of such changes is unknown. We therefore recorded action potentials and ionic currents in cells isolated from the endocardium, midmyocardium, and epicardium of the left ventricle from dogs with and without tachypacing-induced HF. HF greatly increased action potential duration (APD) but attenuated APD heterogeneity in the three regions. Early afterdepolarizations (EADs) were observed in all cell types of failing hearts but not in controls. Inward rectifier K(+) current (I(K1)) was homogeneously reduced by approximately 41% (at -60 mV) in the three cell types. Transient outward K(+) current (I(to1)) was decreased by 43-45% at +30 mV, and the slow component of the delayed rectifier K(+) current (I(Ks)) was significantly downregulated by 57%, 49%, and 58%, respectively, in epicardial, midmyocardial, and endocardial cells, whereas the rapid component of the delayed rectifier K(+) current was not altered. The results indicate that HF remodels electrophysiology in all layers of the left ventricle, and the downregulation of I(K1), I(to1), and I(Ks) increases APD and favors occurrence of EADs.
Recombinant Antitoxic and Antiinflammatory Factor from the Nonvenomous Snake Python reticulatus:  Phospholipase A2 Inhibition and Venom Neutralizing Potential, (2000)

From the serum of the nonvenomous snake Python reticulatus, a new phospholipase A(2) (PLA(2)) inhibitor termed phospholipase inhibitor from python (PIP) was purified by sequential chromatography and cloned to elucidate its primary structure and fundamental biochemical characteristics. A cDNA clone encoding PIP was isolated from the liver total RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). It contained a 603 bp open reading frame that encoded a 19-residue signal sequence and a 182-residue protein. PIP showed about 60% sequence homology with those PLA(2) inhibitors having a urokinase-type plasminogen activator receptor-like domain structure. PIP was also functionally expressed as a fusion protein in Escherichia coli to explore its potential therapeutic significance. The recombinant PIP was shown to be identical to the native form in chromatographic behavior and biochemical characteristics. Both the native and recombinant PIP appear to exist as a hexamer of 23-kDa subunits having an apparent molecular mass of approximately 140 kDa. PIP showed ability to bind to the major PLA(2) toxin (daboiatoxin, DbTx) of Daboia russelli siamensis at 1-2-fold molar excess of inhibitor to toxin. It exhibited broad spectra in neutralizing the toxicity of various snake venoms and toxins and inhibited the formation of edema in mice. Our data demonstrate the venom neutralizing potential of the recombinant PIP and suggest that the proline-rich hydrophobic core region may play a role in binding to PLA(2).
Use of allpass networks to tune the center frequency of sigma delta modulators (2002)

The standard sigma-delta modulator uses feedback around 1-bit quantizers to transform open loop integrator poles into closed loop transmission zeros of the noise transfer function. The DC transmission zeros permit high resolution quantization of data over a frequency band in their neighborhood. Closed loop zeros can be shifted to arbitrary spectral locations by doubling the number of integrators and then applying local feedback around integrator pairs thereby converting them to resonators. These spectrally shifted zeros support high resolution quantization at the selected (arbitrary) center frequency. In the paper the authors describe an alternate technique for shifting the open loop poles around the unit circle. In this method, rather than forming resonators, they use a spectral transformation on the baseband process performed by embedded all-pass filters. >
Rapid communication: a novel DNA polymorphism of the bovine calpain gene detected by PCR-RFLP analysis. (1996)

Journal Article Rapid communication: a novel DNA polymorphism of the bovine calpain gene detected by PCR-RFLP analysis Get access H. M. Zhang, H. M. Zhang 2Department of Animal Sciences, University of Arizona, Tucson 85721, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S. K. DeNise, S. K. DeNise 2Department of Animal Sciences, University of Arizona, Tucson 85721, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar R. L. Ax R. L. Ax 2Department of Animal Sciences, University of Arizona, Tucson 85721, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Animal Science, Volume 74, Issue 6, June 1996, Page 1441, https://doi.org/10.2527/1996.7461441x Published: 01 June 1996 Article history Received: 27 December 1995 Accepted: 22 March 1996 Published: 01 June 1996
The Usefulness of Electrical Stimulation for Assessing Pedicle Screw Placements (2000)

The purpose of this study was to further establish the efficacy of pedicle screw stimulation as a monitoring technique to avoid nerve root injury during screw placement. The study population consisted of 662 patients in whom 3,409 pedicle screws were placed and tested by electrical stimulation. If stimulation resulted in a myogenic response at a stimulation intensity of 10 mA or less, the placement of the screw was inspected. Inspection was necessary for 3.9% of the screw placements in 15.4% of the study population. None of the patients in the study experienced any new postoperative neurologic deficits. These findings provide guidelines for the interpretation of stimulation data and support the use of this technique as an easy, inexpensive, and quick method to reliably assess screw placements and protecting neurological function.
Imeglimin - A New Oral Anti-Diabetic that Targets the Three Key Defects of type 2 Diabetes (2011)

The objective of this collated research paper is to highlight the anti-diabetic effects and mode of action of imeglimin, the first in a new tetrahydrotriazine-containing class of oral anti-diabetic agents: the glimins. Imeglimin acts on both insulin resistant organs (liver and muscle) and pancreatic -cells (insulin secretion in response to glucose and protection against apoptosis).
No reference image quality assessment based on local binary pattern statistics (2013)

Multimedia, including audio, image and video, etc, is a ubiquitous part of modern life. Evaluations, both objective and subjective, are of fundamental importance for numerous multimedia applications. In this paper, based on statistics of local binary pattern (LBP), we propose a novel and efficient quality similarity index for no reference (NR) image quality assessment (IQA). First, with the Laplacian of Gaussian (LOG) filters, the image is decomposed into multi-scale sub-band images. Then, for these sub-band images across different scales, LBP maps are encoded and the LBP histograms are formed as the quality assessment concerning feature. Finally, by support vector regression (SVR), the extracted features are mapped to the image's subjective quality score for NR IQA. The experimental results on LIVE IQA database show that the proposed method is strongly related to subjective quality evaluations and competitive to most of the state-of-the-art NR IQA methods.
Electrostrictive behavior of poly(vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) (2003)

The mechanism underlying the large electric-field-induced strains in terpolymers of vinylidene fluoride, trifluoroethylene, and chlorotrifluoroethylene was investigated. The electrostrictive strain increased by an order of magnitude with increasing temperature, up to the Curie transition, and was essentially invariant to temperature thereafter. Infrared absorption spectra, obtained as a function of both temperature and electric field strength, revealed no change in the crystal phase structure for electric fields sufficient to induce longitudinal strains of ∼1%. Thus, the electrostriction observed herein is not due to crystal phase conversion. The Maxwell strain was also negligible under all conditions, because of the terpolymer’s high mechanical modulus (10 to 100 MPa). The mechanical properties exhibit an anomalous change in behavior near the Curie transition, whose origin is unclear.
Collagen Vascular Disease???Related Lung Disease (2004)

Collagen vascular disease (CVD) can cause a variety of lung abnormalities, including usual interstitial pneumonia, nonspecific interstitial pneumonia, organizing pneumonia, diffuse alveolar damage, lymphoid interstitial pneumonia, bronchiectasis, constrictive bronchiolitis, follicular bronchiolitis, alveolar hemorrhage, pulmonary hypertension, and drug-induced lung disease. The frequency of each lung disease is different among underlying CVDs. Although high-resolution computed tomography (HRCT) findings of lung disease are often nonspecific, there are some characteristic HRCT findings for some lung diseases based on pathologic findings.
Electronic energy transfer from pyrazine to a silver(111) surface between 10 and 400 Å (1982)

The phosphorescence lifetime of pyrazine molecules above a Ag(111) surface has been measured as a function of molecule–metal seperation between 10 and 400 Å. In contrast to the previous work on the pyrazine/Ag system, we find that the lifetime decreases monotonically as the pyrazine approaches the metal surface. The distance dependence of the phosphorescence lifetime is described quantitatively using the classical treatment of nonradiative energy transfer of Chance, Prock, and Silbey.
Amplifying quantum signals with Josephson tunnel junction circuits (2008)

Amplifiers are crucial in every experiment carrying out a very sensitive measurement. However, they always degrade the information by adding noise. Quantum mechanics puts a limit on how small this degradation can be. Theoretically, the minimum noise energy added by a phase-preserving amplifier to the signal it processes amounts at least to half a photon at the signal frequency. In this article, we show that we can build a practical microwave amplifying circuit that fulfills the minimal requirements to reach this quantum limit. The readout of solid-state qubits, and more generally, the measurement of very weak signals in various areas of science, can benefit from this new superconducting device. We also discuss how our circuit can be the basic buiding block for a variety of practical applications such as frequency conversion with and without photon number gain, dynamic cooling and production of entangled signal pairs.
Rationality and Revolution: A Response to Holmstrom on the Logic of Working Class Collective Action (1987)

In ‘Rationality and Revolution’ Nancy Holmstrom addresses an issue that has gained considerable currency among social and political theorists. She asks what insight, if any, Marxists might glean from rational choice accounts of radical working class collective action. The purpose of this comment is to argue that Holmstrom’s unfavorable estimation of rational choice accounts is ill-conceived. Holmstrom raises two basic objections to rational choice explanations of working class collective action. First, she contends that such accounts are limited, inadequate or incomplete and indicates several manifestations of this purported deficiency. Second, Holmstrom alleges that rational choice accounts are ideologically suspect and, as such, fundamentally at odds with Marxist explanations of revolutionary action. Holmstrom appears to believe that this second line of criticism ‘follows’ (309, 318) in some sense upon the first. H so, it would be sufficient to establish the error of her initial line of argument. Because neither of her criticisms can withstand scrutiny, however, independent reasons will be advanced for rejecting each.
Efficient Shellcode Detection Based on Convolutional Neural Network (2019)

An important method to detect intrusion is to identify attack codes such as shellcode. However, the popular simulation methods seriously slow down the efficiency, while static detection can't guarantee the accuracy of detection. In this paper, we propose an approach based on the combination of static analysis and convolutional neural network. Probes are first used to match key byte sequences to filter benign data and obtain shellcode candidates, then convolutional neural network uses the feature set extracted from the shellcode fragment to classify candidates. In addition, this paper propose several instruction abstraction features for static analysis. Experiment shows that the proposed method can detect multiple malicious code with high detection accuracy, such as plain shellcode and encrypted shellcode.
Ganglioside GM1 Binding Peptides: A Potential Adjuvant for Transcutaneous Immunization (2009)

Cholera toxin (CT) binds ganglioside GM1 and has been used as an adjuvant in transcutaneous immunization. To determine if the adjuvant property of CT was merely due to binding to ganglioside GM1, mice were immunized by the transcutaneous route using hen egg lysozyme (HEL) as the antigen, and either CT or synthetic peptides that bind to ganglioside GM1 as the adjuvant, and the immune responses were evaluated. Both CT and GM1 binding peptides (GM1bp) induced HEL-specific antibodies and T-cell proliferation. However, the immune responses when GM1-bp was used as the adjuvant, was much lower when compared to CT as the adjuvant. GM1-bp maintained or enhanced the co-stimulatory molecules on antigen presenting cells, in particular on JAWS II dendritic cells. Overall, the data suggests that the binding of GM1-bp to ganglioside GM1 alone can induce immune responses to the co-administered antigen.
Advances and Applications in Electroceramics (2011)

This book contains 26 papers from the Magnetoelectric Multiferroic Thin Films and Multilayers; Dielectric Ceramic Materials and Electronic Devices; Recent Developments in High-Temperature Superconductivity; and Multifunctional Oxides symposia held during the 2010 Materials Science and Technology (MS&T'10) meeting, October 17-21, 2010, Houston, Texas. Topics include: Properties; Structures; Synthesis; Characterization; Device Applications; Multiferroics and Magnetoelectrics; YBCO Pinning Methods and Properties; YBCO Processing and Reliability Related Issues; New Superconductors and MgB2.
Mapping Migraine-Specific Quality of Life to Health State Utilities in Patients Receiving Rimegepant (2021)

Clinical Trials NCT03266588.