gebhart/patrepeval huggingface dataset:
Waxing Poetic, Part 2 A Century of Great Moments in Recorded Opera and Song (2001)

Journal Article Waxing Poetic, Part 2 A Century of Great Moments in Recorded Opera and Song Get access LONDON GREEN LONDON GREEN Search for other works by this author on: Oxford Academic Google Scholar The Opera Quarterly, Volume 17, Issue 1, Winter 2001, Pages 10–27, https://doi.org/10.1093/oq/17.1.10 Published: 01 January 2001
Effects of Hydrostatic Pressure and Thermal Loading on Optical Fibers Coated with Multilayer Segmented Young’s Modulus Materials (2012)

In this paper, we have reported two-layer coated fiber with tightly jacketed layer of segmented Youngâs modulus (YM) material. In our proposed model, we have considered six layers out of which first two layers are assumed of soft material and the next four layers consist of hard materials. In our analysis we have dealt with the effects of hydrostatic pressure and thermal loading on microbending loss and refractive index changes of the fiber in radial, tangential, and axial directions. The microbending loss due to lateral pressure was calculated by taking layer thicknesses, Youngâs modulus, Poissonâs ratio, hydrostatic pressure, and thermal loading as parameters of different cases of calculations. The results have shown that increase in soft layersâ thickness reduces the fiber losses. The inclusion of successive hard-material layers causes an increase in the fiber loss. Increase of soft material layersâ thickness has caused increase in loss and reaches a minimum value at a particular thickness of the corresponding layer. As a result, it is shown that increase of the YM of soft layers increases the fiber microbending loss while the increase in case of hard layers would decrease the fiber bending loss. In addition, higher Poissonâs ratio of soft layers would increase the loss but its higher values for hard layers would decrease the loss values.
PDE7, nueva diana terapéutica en enfermedades neurológicas: validación y desarrollo de nuevos inhibidores (2013)

Este trabajo se ha centrado por una parte en la validacion de PDE7 como diana terapeutica en el tratamiento de enfermedades neurologicas, y por otra, en el desarrollo de nuevos inhibidores. Asi, se han empleado diferentes tecnicas computacionales com o docking o estudios de modelizacion molecular para el diseno de nuevos inhibidores. Ademas, se han empleado diferentes modelos animales de enfermedades neurologicas para demostrar la eficacia terapeutica de estos compuestos. Todos los resultados obt enidos han permitido su publicacion en diversas revistas de alto impacto asi como han supuesto la presentacion de tres patentes, licenciadas a companias biotecnologicas.
Deep learning for pulmonary embolism detection on computed tomography pulmonary angiogram: a systematic review and meta-analysis (2021)

Computed tomographic pulmonary angiography (CTPA) is the gold standard for pulmonary embolism (PE) diagnosis. However, this diagnosis is susceptible to misdiagnosis. In this study, we aimed to perform a systematic review of current literature applying deep learning for the diagnosis of PE on CTPA. MEDLINE/PUBMED were searched for studies that reported on the accuracy of deep learning algorithms for PE on CTPA. The risk of bias was evaluated using the QUADAS-2 tool. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curves were plotted. Seven studies met our inclusion criteria. A total of 36,847 CTPA studies were analyzed. All studies were retrospective. Five studies provided enough data to calculate summary estimates. The pooled sensitivity and specificity for PE detection were 0.88 (95% CI 0.803-0.927) and 0.86 (95% CI 0.756-0.924), respectively. Most studies had a high risk of bias. Our study suggests that deep learning models can detect PE on CTPA with satisfactory sensitivity and an acceptable number of false positive cases. Yet, these are only preliminary retrospective works, indicating the need for future research to determine the clinical impact of automated PE detection on patient care. Deep learning models are gradually being implemented in hospital systems, and it is important to understand the strengths and limitations of these algorithms.
Thermodynamics of ion association in aqueous solution (1960)

The first page of this article is displayed as the abstract.
Evidence for Virus-Related and Unrelated Antigens on Murine LymphomasInduced by Chemical Carcinogens (1973)

Ether-treated extracts of 7 CS7BL lymphosarcomas induced by 3 different chemical carcinogens, urethan (Ur), N-nitrosomethylurea (NMU) or 7,12-dimethylbenz[a]anthracene (DMBA), were tested by immunodiffusion for the presence of group-specific antigens and all were found positive. Direct cytotoxic tests and absorption tests with a murine anti-G serum and a rat antiradiation leukemia virus (RadLV) serum, using 9 other Ur, NMU, or DMBA-induced CS7BL lymphomas, demonstrated the presence of common cell-surface, virus-related antigens on the virus-induced E♂G2 leukemia, the RadLV lymphoma, and the chemically induced lymphomas. An antiserum raised in CS7BL against Ur-induced C3Hf or BALB/c lymphomas exhibited a complement-dependent cytotoxic activity against 21 of 22 CS7BL lymphomas induced by the 3 different carcinogens, against the EL4 leukemia but not against the virus-induced E♂G2 leukemia. The E♂G2 leukemia also failed to absorb completely the specific cytotoxicity of the entlehemlcally induced lyrmphomas antiserum. CS7BL multiparous or antiembryo sera exerted a complement-dependent cytotoxicity on the chemically induced lymphomas but not on the E♂G2 leukemia. Thus carcinogeninduced lymphosarcomas, in addition to Gross virus-related antigens, possess tumor-specific, cell-surface, cross-reacting antigens not related to the virus, which may represent modified expressions of cellular genetic information and/or a retrogenetic expression.
[Localization of EGFP-DPF-1 expressed and secreted by HeLa cells in oocytes]. (2003)

The eukaryotic expression plasmid pEGFP-N1/DPF-1 was constructed through fusing rabbit oviduct-specific glycoprotein (DPF-1) gene to the 5' terminus of eGFP gene. After transfecting the recombinant plasmid into HeLa cells, we got some cell strains expressing and secreting eGFP-DPF-1 stably. The apparent molecular weight of the fusion protein was up to 120 KD indicating the fusion protein was modified. Rabbit oocyte-cumulus cells complexes (COC), the cumulus cells-deprived oocytes or oviductal oocytes were co-cultured with the cell strain or cultured in the conditioned medium derived from the cell strain to observe the distribution of DPF-1 in oocytes after incubation. The results revealed that DPF-1 but not GFP alone associated with zona pellucidae (ZP) of oocytes, especially in the inner layer of ZP, and was evenly distributed in dot-like shape on the outer surface of the cytoplasmic membrane. In contrast, the cumulus cells around the oocyte did not interfere the association of DPF-1 with oocyte, and no trace of DPF-1 was found in the cumulus cells. The experiment proved that the oviductin expressed and secreted by eukaryotic cells in vitro could bind to oocytes, and was directly observed by using green fluorescent protein as a tracer. These results provided some interesting informations for the further studying on the functions of the oviductin.
Laser absorption measurements of atomic metastable densities (1983)

Helium triplet metastable densities have been calculated from measured absorption of resonant, CW, UV laser radiation on the 23S-53P transition at 294.511 nm. Gas temperatures have also been deduced by measuring the Doppler width of this transition. A 3 mm bore capillary tube filled to pressures in the range 1-8 Torr and run at currents in the range 2.5-80 mA was studied. With constant discharge current (60 mA) at a maximum value for the triplet metastable density of 11*1012 cm-3 at about 2 Torr was obtained. The metastable densities show the expected saturation behaviour, saturating at currents above 40 mA. Experimental values are used in conjunction with the rate equation describing the metastable level population in order to estimate the rate coefficient for loss of metastables through electron collisions. Mention is made of the use of the visible laser radiation for measuring the UV laser wavelength in a Kowalski-type wavemeter.
Prevalence and predictive factors for clinical outcomes of isolated functional tricuspid regurgitation (2022)

A considerable number of patients had isolated functional TR. Extracardiac factors such as renal function, hemoglobin and platelet are important in determining clinical outcomes.
NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1 (1992)

The solution structure of two homologous naturally occurring antimicrobial peptides, rabbit defensin NP-2 and human defensin HNP-1, have been determined by two-dimensional nuclear magnetic resonance spectroscopy, distance geometry, and restrained molecular dynamics calculations. The structure of these defensins consists of an antiparallel beta-sheet in a hairpin conformation, a short region of triple-stranded beta-sheet, several tight turns, and a loop region that has a well-defined local structure but with a global orientation that is not well-defined with respect to the rest of the molecule. The solution structures of these two peptides are compared with the solution and crystal structures of two other homologous defensins. The structures for the defensins are also compared with known structures of other naturally occurring antimicrobial peptides.
Impact of Electrostatic Deposition of Anionic Polysaccharides on the Stability of Oil Droplets Coated by Lactoferrin (2010)

The purpose of this study was to investigate the effects of three anionic polysaccharides (low methoxyl pectin (LMP), high methoxyl pectin (HMP) and alginate) on the physicochemical properties and stability of lactoferrin (LF)-coated lipid droplets. LMP, HMP and alginate were shown to adsorb to the surfaces of LF-coated droplets at neutral pH, which was primarily attributed to electrostatic attraction between anionic groups on the polysaccharide molecules and cationic patches on the protein surfaces. In the absence of polysaccharide, the LF-coated droplets were highly unstable to aggregation when heated above about 60 °C at pH 7, presumably because thermal denaturation of the adsorbed proteins increased droplet attraction. The addition of either LMP or HMP prior to heating greatly improved the thermal stability of the emulsions, with no aggregation being observed from 30 to 90 °C. On the other hand, the presence of anionic polysaccharides had little effect on emulsion stability or even promoted emulsion instability when 0 to 200 mM NaCl or CaCl2 was added. This study shows that the stability of LF-coated lipid droplets can be improved by careful selection of an appropriate type and amount of anionic polysaccharide to incorporate.
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol (2017)

Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action. A marked antiviral activity not only of 25HC but also of 27HC against HSV-1 was observed either if the oxysterols were added before or after infection, suggesting an activity unrelated to the viral entry inhibition as proposed by previous literature. Therefore, the relation between the pro-inflammatory activity of oxysterols and the activation of NF-kB and IL-6 induced by HSV-1 in the host cell was investigated. Indeed, cell pre-incubation with oxysterols further potentiated IL-6 production as induced by HSV-1 infection with a consequent boost of the interleukin's total cell secretion. Further, a direct antiviral effect of IL-6 administration to HSV-1 infected cells was demonstrated, disclosing an additional mechanism of antiviral action by both 25HC and 27HC.
Assistive tools for system integration, deployment, monitoring, and maintenance of ocean energy devices (2010)

This paper describes a set of assistive tools and technologies for system integration, deployment, monitoring, and maintenance of ocean energy devices. The flexible design of these tools enables their use as separate standalone modules, as well as their integration into a unique integrated system. A major component of the system is a smart remotely operated vehicle ROV LATIS — a novel, multi-mode of operation marine robotics vehicle designed for flexibility in near seabed operations from shallow inshore waters out to the continental shelf edge. Ocean energy technologies play an important part in meeting the Irish government's energy strategy, which targets 33 per cent of Irish electricity to be generated from renewable sources by 2020. The assistive tools, proposed in this paper, will help developers of ocean energy devices in meeting this target during different stages of design, deployment, and operation.
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice. (2022)

Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated during endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues such as hypoxia or nutrient shortage and high metabolic/protein folding demand. To cope with those stresses, cancer cells utilize IRE1 signaling as an adaptive mechanism. Here we report the discovery of novel IRE1 inhibitors identified through a structural exploration of the IRE1 kinase domain. We first characterized the candidates in vitro and in cellular models. We showed that all molecules inhibit IRE1 signaling and sensitize glioblastoma cells to the standard chemotherapeutic temozolomide (TMZ). From these inhibitors, we retained a Blood-Brain Barrier (BBB) permeable molecule (Z4P) and demonstrated its ability to inhibit Glioblastoma (GB) growth and to prevent relapse in vivo when administered together with TMZ. These results support the attractiveness of IRE1 as an adjuvant therapeutic target in GB. We thus satisfy an unmet need for targeted, non-toxic, IRE1 inhibitors as adjuvant therapeutic agents against GB.
A verifiable fully homomorphic encryption scheme to secure big data in cloud computing (2017)

Performing smart computations in a context of cloud computing and big data is highly appreciated today. Fully homomorphic encryption (FHE) is a smart category of encryption schemes that allows working with the data in its encrypted form. It permits us to preserve confidentiality of our sensible data and to benefit from cloud computing powers. Currently, it has been demonstrated by many existing schemes that the theory is feasible but the efficiency needs to be dramatically improved in order to make it usable for real applications. One subtle difficulty is how to efficiently handle the noise. This paper aims to introduce an efficient and verifiable FHE based on a new mathematic structure that is noise free.
FACTORS AFFECTING TESTICULAR METABOLISM AND FUNCTION (1963)

Summary. Investigations were conducted on the in-vitro metabolic activity of rabbit testicular tissue after exposing the testis to abdominal temperatures for 2, 6 or 24 hr. Metabolic activity increased with the shorter exposure and then significantly decreased as compared with that of normal testicular tissue. Tissue treated in this way recovered its normal metabolic activity when subjected for 30 min to an ice-cold glucose solution. Tissues exposed to abdominal temperature for 24 hr were found to contain 12% less glucose and 27% less lactic acid than control tissues. This study suggests that spermatogenic arrest which results from exposure of the testis to elevated temperatures may be caused by reduced levels of substrate in the tissue.
A new database for medical images and information (2007)

We present a medical image and medical record database for the storage, research, transmission, and evaluation of medical images, as well as tele-medicine applications. Any medical image from a source that supports the DICOM standard can be stored and accessed, as well as associated analysis and annotations. Information and image retrieval can be done based on patient info, date, doctor's annotations, features in the images, or a spatial combination of features. Secure access and transmission is addressed for tele-medicine applications. This database application follows all HIPPA regulations.
Combined framing and FEC coding for digital multiplex signals (2002)

A combined framing and error control scheme is proposed for the DS3 signal by replacing the F-bits with FEC parity check bits. A suitable extended and shortened Hamming code is used. A fast syndrome computation scheme is developed for the DS3-FEC code with distributed parity check bits to facilitate faster reframe times. The proposed scheme has a better overall framing performance than that of F-bit framing. It also offers the output BER reduction to approximately 1360 P/sub e//sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Formation of Glycerol Dehydrogenase by Microorganisms (1982)

Journal Article Formation of Glycerol Dehydrogenase by Microorganisms Get access Hideaki Yamada, Hideaki Yamada Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Akihiko Nagao, Akihiko Nagao Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Nishise, Hiroshi Nishise Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshiki Tani Yoshiki Tani Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 46, Issue 9, 1 September 1982, Pages 2325–2331, https://doi.org/10.1080/00021369.1982.10865431 Published: 01 September 1982 Article history Received: 14 April 1982 Published: 01 September 1982
Using Lines-of-Solutions to Understand Fracture Conductivity and Fracture Cleanup (2011)

Abstract Evaluation of fracturing treatments in tight-gas sands is often frustrated by uniqueness problems when matching gas rates and bottomhole flowing pressure (BHFP) data alone. A fit-for-purpose simulator was used to match gas rates, BHFP, cumulative water, and composition of the water during cleanup after a fracturing treatment.The simulator models physics of flow and chemical physics to provide improved history matching of the cleanup process. The well was cycled through several production and shut-in periods. Pressure transient analysis(PTA)was used along with a recently published line-of-solutions concept for evaluating the evolution of properties of the reservoir/fracture system. History matching of the well-returns data with the fracture-cleanup model provided multiple solutions when matching gas, water, and BHFP. These solutions all fell on a "line-of-solutions" using a special plot of reservoir properties as a function of conductive length. In addition, a new line-of-solutions was discovered relating fracture conductivity as a function of conductive length. PTA of several buildups provided lines-of-solutions that evolved during the course of the cleanup. These tools demonstrated that the conductive length was roughly 100 ft, but apparently cleaned up to at least twice that over the next several weeks. The fracture conductivity was much lower than expected and was the cause of the disappointing productivity. This work demonstrates that matching well-return compositionswith a fracture-cleanup model capable of chemical physics can lead to improved interpretations of both reservoir properties and fracture structure. The two lines-of-solutions provide a potentially powerful method of understanding the reservoir/fracture system
Structured speech modeling (2006)

Modeling dynamic structure of speech is a novel paradigm in speech recognition research within the generative modeling framework, and it offers a potential to overcome limitations of the current hidden Markov modeling approach. Analogous to structured language models where syntactic structure is exploited to represent long-distance relationships among words , the structured speech model described in this paper makes use of the dynamic structure in the hidden vocal tract resonance space to characterize long-span contextual influence among phonetic units. A general overview is provided first on hierarchically classified types of dynamic speech models in the literature. A detailed account is then given for a specific model type called the hidden trajectory model, and we describe detailed steps of model construction and the parameter estimation algorithms. We show how the use of resonance target parameters and their temporal filtering enables joint modeling of long-span coarticulation and phonetic reduction effects. Experiments on phonetic recognition evaluation demonstrate superior recognizer performance over a modern hidden Markov model-based system. Error analysis shows that the greatest performance gain occurs within the sonorant speech class.
Fast code design for sensors in noncooperative networks (2010)

In this paper, we consider the problem of waveform design for radar sensors that operate in a noncooperative network. This is a system in which multiple radars share some common features, but they do not cooperate in the detection stage of processing. Our goal is to increase the performance of an element of the sensor network, and, at the same time, to limit the interference induced by this element of interest on remaining sensors. The resulting problem is Nondeterministic Polynomial hard, namely an optimal solution can not be calculated in polynomial time. However, it is possible to relax the original problem into a Semidefinite Programming Problem, which is convex. This convex problem can be solved in polynomial time. Starting from an optimal solution to the relaxed problem, we construct a near-optimal solution of the original nonconvex problem, and evaluate its quality via the approximation bound. The proposed technique, referred to as “Waveform Design in Noncooperative Environment” (WDNE), enjoys the benefits of polynomial time complexity. Finally, we analyze via simulation the performance of the WDNE procedure.
Performance studies of a Prolog machine architecture (1985)

article Free Access Share on Performance studies of a Prolog machine architecture Authors: T. P. Dobry Computer Science Division, University of California,Berkeley, Berkeley, California Computer Science Division, University of California,Berkeley, Berkeley, CaliforniaView Profile , A. M. Despain Computer Science Division, University of California,Berkeley, Berkeley, California Computer Science Division, University of California,Berkeley, Berkeley, CaliforniaView Profile , Y. N. Patt Computer Science Division, University of California,Berkeley, Berkeley, California Computer Science Division, University of California,Berkeley, Berkeley, CaliforniaView Profile Authors Info & Claims ACM SIGARCH Computer Architecture NewsVolume 13Issue 3June 1985 pp 180–190https://doi.org/10.1145/327070.327161Published:01 June 1985Publication History 60citation339DownloadsMetricsTotal Citations60Total Downloads339Last 12 Months35Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF