gebhart/patrepeval huggingface dataset:
Unraveling how electronic and spin structures control macroscopic properties of manganite ultra-thin films (2015)

Perovskite manganites exhibit fascinating transport and magnetic properties, essential for fundamental research and applications. With the development of thin film technologies, more exotic properties have been observed in doped-manganites over a wide range of temperature. Unraveling the interplay of spin, charge and orbital degrees of freedom that drives exotic, macroscopic properties is therefore crucial for the understanding of strongly correlated electron systems. Here, using a combination of transport, spectroscopic ellipsometry, X-ray absorption spectroscopy and X-ray magnetic circular dichroism, we observe two concomitant electronic and magnetic phases (insulating paramagnetic phase for T>195 K and insulating canted-ferromagnetic for T<140 K) with an intermediate metal-like state in ultra-thin La0.7Sr0.3MnO3 (LSMO) film on DyScO3 substrate. Surprisingly, the O2p-Mn3d hybridization strength reduces with decreasing temperature, driving the system more insulating and ferromagnetic. The Jahn–Teller effect weakens markedly within the intermediate temperature range, making the system more metal-like. We also apply this comprehensive method to a LSMO film on SrTiO3 substrate for comparison. Our study reveals that the interplay of the O2p-Mn3d hybridization and the dynamic Jahn–Teller splitting controls the macroscopic transport and magnetic properties in ultra-thin manganites. The interplay between hybridization, orbital occupancy and spin governs the transport and magnetic properties of ultrathin manganites. This finding was made by scientists in Singapore, China and Indonesia based on a new analysis of a doped manganite ultrathin film. Thin films of doped perovskite manganites exhibit exotic properties, but it is unclear what roles the spin, charge and orbital degrees of freedom of these strongly correlated electron systems play in generating such properties. Andrivo Rusydi, Junling Wang and collaborators observed an insulating, ferromagnetic phase below 140 kelvin, an insulating, paramagnetic phase above 195 kelvin, and a metal-like state at intermediate temperatures in their film. They found that the O2p–Mn3d hybridization strength drops with temperature, making the system more insulating and ferromagnetic, whereas the Jahn-Teller effect decreases dramatically in the intermediate temperature range, making the system more metal-like. The interplay between hybridization, orbital occupancy and spin that governs the macroscopic transport and magnetic properties of ultra-thin manganites is revealed using a combination of spectroscopic ellipsometry, X-ray absorption, X-ray magnetic circular dichroism and transport measurements.
Simultaneous use of Rhodamine 123, phycoerythrin, Texas red, and allophycocyanin for the isolation of human hematopoietic progenitor cells (1991)

Abstract The supravital, mitochondrial specific dye Rhodamine 123 (R123) was used in conjunction with three monoclonal antibodies to isolate a population of human bone marrow (BM) cells enriched for hematopoietic progenitor cells. BM cells stained with phycoerythrin‐HLA‐DR, Texas red‐CD34, allophycocyanin‐CD15, and R123 were fractionated using four‐color immunofluorescence cell sorting. Cells expressing CD34 but not HLA‐DR and CD15 (CD34 + HLA‐DR − CD15 − ) were subdivided according to their reactivity with R123 into quiescent, R123 dull (R + ) or cycling, R123 bright (R ++ ) subpopulations. Morphological analysis and hematopoietic progenitor cell assays indicated that CD34 + HLA‐DR − CD15 − R + cells contained larger numbers of blast cells and colony forming units than CD34 + HLA‐DR − CD15 − R ++ cells. The flow cytometer settings used to accommodate the detection of the R123 fluorescence in combination with that of three other fluorochromes are described.
Adsorption of water and gaseous species on calcite surfaces at different relative humidity and temperature (2018)

Adsorption of water and gaseous species on calcite surfaces at different relative humidity and temperature
Insulin-Like Growth Factor (IGF)-Binding Protein-3 Blocks IGF-I-Induced Receptor Down-Regulation and Cell Desensitization in Cultured Bovine Fibroblasts* (1991)

Insulin-like growth factor-I (IGF-I) initiates its diverse biological effects by binding to type I IGF receptors on cells. In addition, IGF-I associates with distinct proteins that can modulate its actions. One of these IGF-binding proteins, IGFBP-3, is the major circulating form in adults and is produced by many cells in culture. We investigated the effect of purified bovine IGFBP-3 on IGF-I binding and IGF-I stimulation of amino acid uptake and DNA synthesis in cultured bovine fibroblasts, a cell culture system highly suitable for these types of studies. Incubation of cells with IGF-I resulted in time- and dose-dependent decreases in [125I]IGF-I binding and IGF-I stimulated [3H]aminoisobutyric acid uptake and [3H]thymidine incorporation. Preincubation with 4 nM IGF-I resulted in a 50-60% decrease in IGF-I receptor binding, accompanied by marked decreases in IGF-I-stimulated [3H]aminoisobutyric acid uptake (50-60%) and [3H]thymidine incorporation (80-90%). Preincubation with the IGF-I analog [QAYL]IGF-I (4 nM) or with 100 nM insulin, growth factors that bind and activate type I IGF receptor signalling but have little or no affinity for IGFBP-3, had effects comparable to IGF-I, decreasing both IGF-I binding and action 50-95%. The addition of IGFBP-3 during the preincubation period with IGF-I blocked the decrease in receptor availability and prevented the cells from becoming desensitized. IGFBP-3 did not prevent the [QAYL]IGF-I- or insulin-induced receptor loss and cellular resistance to IGF-I. These data indicate that IGFBP-3 can prevent IGF-I-induced receptor down-regulation, a process that renders cells refractory to further stimulation by IGF-I. Thus, cell-derived IGFBP-3 may function in a buffering capacity to restrict IGF-I and target cell interaction, thereby modulating the biological response to changes in local IGF-I levels.
3D-Based Reasoning with Blocks, Support, and Stability (2013)

3D volumetric reasoning is important for truly understanding a scene. Humans are able to both segment each object in an image, and perceive a rich 3D interpretation of the scene, e.g., the space an object occupies, which objects support other objects, and which objects would, if moved, cause other objects to fall. We propose a new approach for parsing RGB-D images using 3D block units for volumetric reasoning. The algorithm fits image segments with 3D blocks, and iteratively evaluates the scene based on block interaction properties. We produce a 3D representation of the scene based on jointly optimizing over segmentations, block fitting, supporting relations, and object stability. Our algorithm incorporates the intuition that a good 3D representation of the scene is the one that fits the data well, and is a stable, self-supporting (i.e., one that does not topple) arrangement of objects. We experiment on several datasets including controlled and real indoor scenarios. Results show that our stability-reasoning framework improves RGB-D segmentation and scene volumetric representation.
Focused-ion-beam fuse cutting for redundancy technology (1988)

Fuse cutting with focused ion beams to activate redundancy circuits is proposed, and experiments are reported that verify its potential usefulness. Aluminum fuses covered with a thin passivation layer, which are difficult to cut by conventional laser-beam technology due to the material's high reflectivity, were cut in 5 s. Ga ion beams with 30-kV acceleration voltage, 0.8- mu m beam diameter, and 0.3-A/cm/sup 2/ current density were used. No change in device properties due to focused-ion-beam irradiation was observed unless the focused ion beams were incident directly on the device. It is concluded that the focused-ion-beam programming technique will be useful for redundancy circuit programming.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of Hydroxyurea on the Development of Bacteriophage øX174 (1971)

Hydroxyurea in an appropriate concentration inhibited DNA synthesis in Escherichia coli HF4701 (HCR-) and C (HCR+) without preventing the synthesis of protein and RNA. The drug also inhibited the formation of mature infectious particles of bacteriophage øX174 in E. coli HF4701 without preventing the synthesis of viral protein. The DNA synthesis and the phage formation were recovered upon removal of hydroxyurea.
Confronting economic profit with hierarchy theory: The concept of gain in ecology (2009)

Abstract Contemporary problems are often complicated by values intruding into the arena of material systems. But there have always been values in biology and social science because they are required to assess how biosocial structures have models embodying purpose as an issue separate from the models of the scientists. Values are addressed seriously in economic discourses, and other discussions will benefit from paying attention to how the dismal science does that. Economic notions of profit have values embedded in them in a way that generally does not occur in ecology and the other natural sciences. Here we generalize profit as gain in settings beyond strict economics in a way that encourages placing values properly in biological and historical social systems. Complications of elaborate control quickly enter the scene at this point and in this paper we invoke hierarchy theory to keep levels of analysis straight. Hierarchy theory often invokes dualities and a mix of process and structure that is fluid under changes in level of analysis. Beyond this, the things the hierarchy represents changes over time, so we must extend discourse of level of analysis to include how time forces the use of new levels of analysis as hierarchies change over time. Notions of gain and profit are recursive as the system uses resources and must change strategies to deal with scarcity. This in turn forces increases in efficiency in yet a new round of change. The transition from abundant resources used carelessly to scarce resources used efficiently changes controls in biosocial systems. Such changes over time amount to hierarchical restructuring, which in turn requires of the observer meticulous application of new levels of analysis as the system is redefined. The system bounded at a new hierarchical level encounters dualities embedded in the hierarchical concept of the holon. The holon offers a precision of definition of the new system as it exists as an autonomous whole while still being part of some larger system. We introduce these shifts and dualities using examples from nuclear energy, colonial insects and changes in complex societies such as the Roman Empire and the EU. In the end both ideas of profit and hierarchy theory are clarified in a two‐way exchange that moves forward our understanding of biosocial systems. Copyright © 2009 John Wiley &amp; Sons, Ltd.
The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates (2005)

접수 : 2004년 9월 1일, 승인 : 2004년 10월 13일 책임저자 :김은령, 성애병원 소아과 Correspondence : Eun Ryoung Kim, M.D. Tel : 02)840-7230 Fax : 02)832-8569 E-mail : NICU@chollian.net 나 미숙아, 모유수유, 남아, 두혈종, 영양장애, 출생 후 체중의 감소, 당뇨병 산모 및 임신성 고혈압, 분만촉진제의 사용, 황달 의 가족력 등이 있으며, 한국, 중국, 일본을 비롯한 동양인이 백 인보다 신생아 황달이 많이 발생하고, 흑인에 비해 백인의 황달 발생 빈도가 낮으며, 그리스인 등에서 특발성 신생아 황달이 많 이 발생한다고 알려져 있어 신생아 황달과 유전적 요인과의 연 관성이 있을 것으로 생각되어 왔다 2-10) . Gilbert 증후군과 Crigler-Najjar 증후군은 선천성 불포합빌 리루빈혈증으로 빌리루빈 포합효소로 알려져 있는 Uridine diphosphoglucuronosyl transferase(UDPGT)의 활동도가 감소되 어 있으며, 그 원인이 UGT1A1 유전자의 돌연변이(mutation)라 한국인의 신생아 황달과 UGT1A1 및 CYP1A2 유전자 다형성과의 연관성
Abstract 663: Development of a cancer-specific monoclonal antibody LpMab-2 specific for cancer-type podoplanin (2014)

Abstract Podoplanin is a platelet aggregation-inducing mucin-like sialoglycoprotein that is highly expressed in brain tumors, malignant mesotheliomas, testicular tumors, and lung, esophageal, or head and neck squamous cell carcinomas. Podoplanin has also been reported to be a marker to enrich tumor-initiating cells. We previously established a neutralizing monoclonal antibody (mAb), NZ-1, which inhibits the association between podoplanin and C-type lectin-like receptor-2 (CLEC-2) and blocks the podoplanin-induced platelet aggregation and tumor metastasis. A human chimeric mAb, NZ-8 possesses extremely high antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and showed high anti-tumor activities in several xenograft models. However, those mAbs also react with normal cells including lung type I alveolar cells, renal podocytes, and lymphatic endothelial cells throughout the body. Recently, we established the platform to produce a cancer-specific mAb (CasMab) by combining glycobiology and cell engineering technologies. Herein, we report a novel cancer-specific anti-podoplanin mAb, LpMab-2. In Western-blot analyses, LpMab-2 did not react with sialic acid-deficient podoplanin and O-glycan deficient podoplanin, which were expressed in Lec2 and Lec8 cells, respectively. In enzyme-linked immunosorbent assay using several deletion mutants of podoplanin, the epitope of LpMab-2 was shown to be included in 55-88 amino acids of podoplanin, although almost all anti-podoplanin mAbs recognize platelet aggregation-stimulating (PLAG) domain near the N-terminus. Analyses of glycopeptides produced by Edman degradation revealed that O-glycans were attached to glycosylation sites at residues Thr65, Thr66, Thr70, Ser71, Ser74, and Thr76 around LpMab-2 epitope. LpMab-2 did not react with podoplanin-negative cell lines, indicating that not only glycans but also amino acids of podoplanin are necessary for LpMab-2 reaction. In flow cytometric and immunohistochemical analyses, LpMab-2 reacted with tumor cells, but not with lung type I alveolar cells and lymphatic endothelial cells, suggesting that LpMab-2 recognizes the cancer-type conformation of podoplanin. Furthermore, human chimeric LpMab-2 also showed cancer-specific reaction against podoplanin. Taken together, a cancer-specific mAb LpMab-2 should be useful for molecular targeting therapy against podoplanin without side effects such as respiratory or renal failures and lymphatic edema. The CasMab-producing platform could lead to establishment of the side effect-reducing mAbs. Note: This abstract was not presented at the meeting. Citation Format: Yukinari Kato, Mika K. Kaneko. Development of a cancer-specific monoclonal antibody LpMab-2 specific for cancer-type podoplanin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 663. doi:10.1158/1538-7445.AM2014-663
Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes (2013)

These data indicate Tfh cells may participate in the T1D-relatede immune responses and B cells might play a role in the development of Tfh responses in the disease progression.
Approximate output tracking for nonlinear non‐minimum phase systems with an application to flight control (1994)

Abstract An unstable zero‐dynamics is a known obstruction to inducing exact asymptotic tracking for an open set of output trajectories with internal stability. This paper proposes a procedure for achieving approximate tracking for a nonlinear system whose linearization possesses real right‐half plane zeros. The method is guaranteed to remove the right‐half plane zeros while the other zeros remain in their previous location; moreover, it provides information on the class of signals for which good approximate tracking can be obtained. With other methods, the right‐half plane zeros are eliminated but the final location of the remaining zeros is not known a priori. The design procedure is illustrated on a trajectory control problem of an aircraft in rapid manoeuvres. Simulations illustrate the computations involved and show that precise lateral and longitudinal manoeuvres can be performed, even in the presence of uncertainties.
Worst-Case Pointwise Discretization Error Bounds for Systems with Geometrically Induced Singular Flux Solutions Using Interval Boundary Element Method (2009)

This paper describes the interval boundary element method treatment of the pointwise discretization error for systems with geometrically generated flux singularities. Worst-case interval bounds are provided for the local discretization error for all elements except for the element with a singular flux solution, for which the flux intensity factor is enclosed. An example is presented showing the behavior of the interval bounds on the local discretization error for systems with geometrically induced singularities.
Keratinization of rat vaginal epithelium. III. Effect of estradiol on keratinization (1989)

Effect of estradiol-17 beta on rat vaginal epithelial cells (VEC) was studied by transmission electron microscopy. During the normal estrous cycle in adult rats keratinization and exfoliation of VEC was observed only in the estrus phase, though tonofilament bundles were seen distributed in the cytoplasm of the VEC during the proestrus and, to a lesser extent, in the diestrus phase. Electron microscope data on adult ovariectomised, immature and neonatally estradiol-primed rats demonstrated keratinization of the VEC within 24 h of injection. Proliferative activity was observed in the basal cells in primed animals. The basal cells remained cuboidal whereas cells of intermediate and luminal layers became flattened. These cells showed irregular profiles and, therefore, enhanced numbers of cellular junctions (desmosomes) were observed compared to control groups. Many tonofilament bundles were seen in the cytoplasm of cells belonging to intermediate and luminal layers in primed animals.
Upper gastrointestinal tract bleeding management: Belgian guidelines for adults and children. (2011)

The current guidelines for the management of UGIB include recommendations for the diagnostic process, general supportive care, pharmacological therapy aiming at bleeding control, specific and endoscopic treatment of acute bleeding and follow-up for both gastro-duodenal ulcers and portal hypertension-induced bleeding.
Quantitative resistance to crown rust: the role of its components for breeding varieties (2004)

Selection of genotypes for quantitative resistance to oat crown rust based on its components needs the knowledge of the association of these components with each other and with the amount of disease in the field, represented by AUDPC. This work aimed to determine these correlations, based on results of previous trials, in which the reaction of 31 white oat genotypes was tested and the resistance components were quantified. Correlations were usually low, among the resistance components with each other as well as the components with the amount of disease in the field. Higher correlations with AUDPC, and consistent among years, were infection frequency in seedlings and latent period and pustule size in adult plants. All other possible correlations were very low. These data suggest that the resistance components mentioned can influence the expression of quantitative resistance in field in a slightly more important manner. Nevertheless, low correlation of resistance components with each other indicates that genotype selection, in this hostpathogen interaction, must not be accomplished on the basis of a single resistance component assessment. The correlation analysis suggests that the expression of quantitative resistance to oat crown rust is not conditioned by a single resistance component only but by the group effect of all of them. In addition, it is possible that different mechanisms are involved in each genotype, in a way that the more important resistance component in one genotype may not be the same in another.
A survey of the antidote preparedness in Norwegian hospitals (2021)

We found varying compliance with the national recommendations for antidote storage in hospitals. To strengthen antidote preparedness, we recommend standardised European guidelines to support national guidelines.
Establishing a Clinical Protocol for Velopharyngeal MRI and Interpreting Imaging Findings (2022)

Traditional imaging modalities used to assess velopharyngeal insufficiency (VPI) do not allow for direct visualization of underlying velopharyngeal (VP) structures and musculature which could impact surgical planning. This limitation can be overcome via structural magnetic resonance imaging (MRI), the only current imaging tool that provides direct visualization of salient VP structures. MRI has been used extensively in research; however, it has had limited clinical use. Factors that restrict clinical use of VP MRI include limited access to optimized VP MRI protocols and uncertainty regarding how to interpret VP MRI findings. The purpose of this paper is to outline a framework for establishing a novel VP MRI scan protocol and to detail the process of interpreting scans of the velopharynx at rest and during speech tasks. Additionally, this paper includes common scan parameters needed to allow for visualization of velopharynx and techniques for the elicitation of speech during scans.
Optimal reconfiguration of constellation using adaptive innovation driven multiobjective evolutionary algorithm (2021)

Constellation reconfiguration is a critical issue to recover from the satellite failure, maintain the regular operation, and enhance the overall performance. The constellation reconfiguration problem faces the difficulties of high dimensionality of design variables and extremely large decision space due to the great and continuously growing constellation size. To solve such real-world problems that can be hardly solved by traditional algorithms, the evolutionary operators should be promoted with available domain knowledge to guide the algorithm to explore the promising regions of the trade space. An adaptive innovationdriven multi-objective evolutionary algorithm (MOEA-AI) employing automated innovation (AI) and adaptive operator selection (AOS) is proposed to extract and apply domain knowledge. The available knowledge is extracted from the final or intermediate solution sets and integrated into an operator by the automated innovation mechanism. To prevent the overuse of knowledge-dependent operators, AOS provides top-level management between the knowledge-dependent operators and conventional evolutionary operators. It evaluates and selects operators according to their actual performance, which helps to identify useful operators from the candidate set. The efficacy of the MOEA-AI framework is demonstrated by the simulation of emergency missions. It was verified that the proposed algorithm can discover a non-dominant solution set with better quality, more homogeneous distribution, and better adaptation to practical situations.