gebhart/patrepeval huggingface dataset:
Blind source separation based on a fast-convergence algorithm combining ICA and beamforming (2006)

We propose a new algorithm for blind source separation (BSS), in which independent component analysis (ICA) and beamforming are combined to resolve the slow-convergence problem through optimization in ICA. The proposed method consists of the following three parts: (a) frequency-domain ICA with direction-of-arrival (DOA) estimation, (b) null beamforming based on the estimated DOA, and (c) integration of (a) and (b) based on the algorithm diversity in both iteration and frequency domain. The unmixing matrix obtained by ICA is temporally substituted by the matrix based on null beamforming through iterative optimization, and the temporal alternation between ICA and beamforming can realize fast- and high-convergence optimization. The results of the signal separation experiments reveal that the signal separation performance of the proposed algorithm is superior to that of the conventional ICA-based BSS method, even under reverberant conditions.
Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. (1994)

Stimulation of calcium-activated potassium (KCa) channels in airway smooth muscle cells by phosphorylation-dependent and membrane-delimited, G protein actions has been reported (Kume, H. A. Takai, H. Tokuno, and T. Tomita. 1989. Nature [Lond.]. 341:152-154; Kume, H., M. P. Graziano, and M. I. Kotlikoff. 1992. Proc. Natl. Acad. Sci. USA. 89:11051-11055). We show that beta-adrenergic receptor/channel coupling is not affected by inhibition of endogenous ATP, and that activation of KCa channels is stimulated by both alpha S and cAMP-dependent protein kinase (PKA). PKA stimulated channel activity in a dose-dependent fashion with an EC50 of 0.12 U/ml and maximum stimulation of 7.38 +/- 2.04-fold. Application of alpha S to patches near maximally stimulated by PKA significantly increased channel activity to 15.1 +/- 3.65-fold above baseline, providing further evidence for dual regulatory mechanisms and suggesting that the stimulatory actions are independent. Analysis of channel open-time kinetics indicated that isoproterenol and alpha S stimulation of channel activity primarily increased the proportion of longer duration events, whereas PKA stimulation had little effect on the proportion of short and long duration events, but resulted in a significant increase in the duration of the long open-state. cAMP formation during equivalent relaxation of precontracted muscle strips by isoproterenol and forskolin resulted in significantly less cAMP formation by isoproterenol than by forskolin, suggesting that the degree of activation of PKA is not the only determinant of tissue relaxation. We conclude that beta-adrenergic stimulation of KCa channel activity and relaxation of tone in airway smooth muscle occurs, in part, by means independent of cyclic AMP formation.
Isolation and Characterization of Pepper mottle virus Infecting Tomato in Korea (2008)

A peculiar virus-like disease of tomato showing yellow mosaic and necrotic spots on leaves and necrosis on veins, petioles and stems was observed at the Tomato Experimental Station (TES), Buyeo, Chungcheongnamdo, Korea. The disease incidence at TES fields ranged from 21 to 35% infecting different tomato cultivars. For this reason, to identify the virus infecting tomato and to characterize the virus based on biology, serology, cytology and at molecular level. Here, leaf samples were randomly collected from different infected tomato cultivars at TES fields and greenhouses and tested by ELISA using Pepper mottle virus (PePMoV) and Tomato mosaic virus (ToMV) antisera. Infected saps were mechanically inoculated in different host plants to test for pathogenicity, symptomatology and host ranges. Infected tissues and ultrathin sections were examined by electron microscopy. Finally, putative coat protein and 3'-untranslated region (CP/3'-UTR) fragment was amplified and cloned for sequence determination and analyzed its genetic relationship to existing PepMoV and PVY sequences at the Genbank. Results showed 69% of the samples were positive with PepMoV, 13% with ToMV and 19 % were doubly infected with PepMoV and ToMV. Symptoms greatly varied from different host plants inoculated with tomato leaf sap infected with PepMoV alone and discussed in detailed in this paper. Electron microscopy from infected tissues showed filamentous particles of 720-750nm in length, a typical morphology and size of PepMoV. In addition, cylindrical inclusion bodies, pinwheels, scrolls and laminates with masses of fibrillar inclusions were also found in ultrathin sections. Alignment of the sequences of the CP/3'-UTR revealed >96% sequence identity with PepMoV and only <61% with PVY. Taken together, all these evidences presented clearly indicated that the causal agent infecting tomato at TES was PepMoV and we designated this PepMoV infecting tomato as Tom-sd2 strain in this study.
Field Test Program to Develop Comprehensive Design, Operating, and Cost Data for Mercury Control Systems (2005)

concentrations hundreds of thousands times higher than the levels in surrounding waters. One of the goals of DOE is to develop technologies by 2005 that will be capable of cutting mercury emissions 50 to 70 percent at well under one-half of today's costs. ADA Environmental Solutions (ADA-ES) is managing a project to test mercury control technologies at full scale at four different power plants from 2000--2003. The ADA-ES project is focused on those power plants that are not equipped with wet flue gas desulfurization systems. ADA-ES will develop a portable system that will be moved to four different utility power plants for field testing. Each of the plants is equipped with either electrostatic precipitators or fabric filters to remove solid particles from the plant's flue gas. ADA-ES's technology will inject a dry sorbent, such as fly ash or activated carbon, that removes the mercury and makes it more susceptible to capture by the particulate control devices. A fine water mist may be sprayed into the flue gas to cool its temperature to the range where the dry sorbent is most effective. PG and E National Energy Group is providing two test sites that fire bituminous coals and are both equipped with electrostatic precipitators and carbon/ash separation systems. Wisconsin Electric Power Company is providing a third test site that burns Powder River Basin coal and has an electrostatic precipitator for particulate control. Alabama Power Company will host a fourth test at its Plant Gaston, which is equipped with a hot-side electrostatic precipitator and a downstream fabric filter.
Timing Analysis of Distributed Real-time Control System using Response-time Analysis Tool (2005)

The process of guaranteeing that a distributed real-time control system will meet its timing constraints, is referred to as schedulability analysis. However, schedulability analysis algorithm cannot be simply used to analyze the system because of complex calculations of algorithm. It is difficult for control engineer to understand the algorithm because it was developed in a software engineer's position. In this paper we introduce a Response-time Analysis Tool(RAT) which provides easy way far system designer to analyze the system by encapsulating calculation complexity. Based on the RAT, control engineer can verify whether all real-time tasks and messages in a system will be completed by their deadline in the system design phase.
A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets (2014)

Stable and efficient knockdown of multiple gene targets is highly desirable for dissection of molecular pathways. Because it allows sequence-specific DNA binding, transcription activator-like effector (TALE) offers a new genetic perturbation technique that allows for gene-specific repression. Here, we constructed a multicolor lentiviral TALE-Kruppel-associated box (KRAB) expression vector platform that enables knockdown of multiple gene targets. This platform is fully compatible with the Golden Gate TALEN and TAL Effector Kit 2.0, a widely used and efficient method for TALE assembly. We showed that this multicolor TALE-KRAB vector system when combined together with bone marrow transplantation could quickly knock down c-kit and PU.1 genes in hematopoietic stem and progenitor cells of recipient mice. Furthermore, our data demonstrated that this platform simultaneously knocked down both c-Kit and PU.1 genes in the same primary cell populations. Together, our results suggest that this multicolor TALE-KRAB vector platform is a promising and versatile tool for knockdown of multiple gene targets and could greatly facilitate dissection of molecular pathways.
Seismic detection of a sinkhole using spectral-based analysis (2014)

Summary Seismic data recorded during a survey in the vicinity of a sinkhole revealed distinct resonances at 70 Hz. Frequency domain data inversion based on exact modeling produced effective elastic parameters for the location over the sinkhole. The use of near-field terms proved important for accurate estimation of the effective parameters.
Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring? (2002)

International audience
Influence of Pad Thickness and Surface Roughness on Pad Stiffness (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The prevention of brake squeal in disc brakes is an important concern in designing a brake system because, in terms of quietness, brake squeal reduces a car's commercial value. Over the past years, many studies have been conducted to elucidate the mechanism underlying the occurrence of brake squeal. However, since disc brake squeal is a complex issue caused by the compound influence of friction phenomena and vibrations in the brake system, the problem of brake squeal still has not been completely resolved, even today. In order to propose an effective measure for the prevention of brake squeal, it is necessary to understand the nature of the brake squeal phenomenon.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;We have investigated the influence of the dynamic stiffness of a brake pad (hereinafter referred to as pad stiffness). The pad stiffness was evaluated the results by a pad excitation at frequencies and vibration amplitudes that would cause brake squeal. As a result, one of the factors such as the pressure dependence of the pad stiffness has been known to be a casual factor in the occurrence of brake squeal. Based on these findings, braking systems that minimize brake squeal are developed in the initial design phase. However, even if a brand-new brake pad does not squeal, the wear of the pad may eventually cause brake squeal. The brake structure does not change during braking, but the condition of the pads does because of sliding with the disc rotor. In order to design brakes that do not squeal over the long-term, it is necessary to identify the relationship between brake squeal and the change to pads as they wear down under the force of sliding with the disc rotor.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This study set out to identify the effects that pad thickness and surface roughness have on pad stiffness as the pad wear down. First, we measured the pad stiffness for pads of different thickness. The results showed the pad stiffness increased as pad thickness decreased. Second, we measured the pad stiffness for pads of different roughness. The results showed the pad stiffness increased as pad surface roughness became smoother, especially on the lower pressure range. Finally, base on measurement results, the pad stiffness could be expressed as a series of spring representing a matrix stiffness caused by pad thickness and a surface stiffness caused by pad surface roughness. We examined that the influence of matrix stiffness and surface stiffness had on the pressure dependence of pad stiffness. The results showed that a matrix stiffness was little dependent on pressure, therefore it dominated pad stiffness on the higher pressure range on the one hand, surface stiffness was highly dependent on pressure, therefore it dominated pad stiffness on the lower pressure range.&lt;/div&gt;&lt;/div&gt;
Flexible Silicon Photonic Transmitter with Segmented Modulator and 32 nm CMOS Driver IC (2016)

We present a novel silicon photonic transmitter including 90nm CMOS segmented modulator co-packaged with low power 32nm CMOS driver IC. Optical equalization is demonstrated for the first time with the multi-segment Mach-Zehnder modulator at 22Gb/s.
Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimen (2022)

Understanding and monitoring virus-mediated infections has gained importance since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Studies of high-throughput omics-based immune profiling of COVID-19 patients can help manage the current pandemic and future virus-mediated pandemics. Although COVID-19 is being studied since past 2 years, detailed mechanisms of the initial induction of dynamic immune responses or the molecular mechanisms that characterize disease progression remains unclear. This study involved comprehensively collected biospecimens and longitudinal multi-omics data of 300 COVID-19 patients and 120 healthy controls, including whole genome sequencing (WGS), single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA(+scTCR/BCR)-seq), bulk BCR and TCR sequencing (bulk TCR/BCR-seq), and cytokine profiling. Clinical data were also collected from hospitalized COVID-19 patients, and HLA typing, laboratory characteristics, and COVID-19 viral genome sequencing were performed during the initial diagnosis. The entire set of biospecimens and multi-omics data generated in this project can be accessed by researchers from the National Biobank of Korea with prior approval. This distribution of largescale multi-omics data of COVID-19 patients can facilitate the understanding of biological crosstalk involved in COVID-19 infection and contribute to the development of potential methodologies for its diagnosis and treatment. [BMB Reports 2022; 55(9): 465-471].
Automated Solution-Phase Synthesis of S-Glycosides for the Production of Oligomannopyranoside Derivatives (2020)

Thioglycosides are more resistant to enzymatic hydrolysis than their O-linked counterparts, thereby becoming attractive targets for carbohydrate-based therapeutic development. We report the first development of methods for the site-selective incorporation of S-linkages into automated solution-phase oligosaccharide protocols. The protocols were shown to be compatible with the formation of <i>S</i>- or <i>O</i>-glycosides for the synthesis of mannopyranoside trimmers that incorporate both S- and O-linkages to allow the selective incorporation of an <i>S</i>-glycoside in various stages in an automated program.
PressureFish (2008)

Studies investigating user control of pressure input have reported time-accuracy trade-offs of, on average, over 30%, when interacting with a large number of pressure levels. To increase the level of control with pressure input, we designed and evaluated four different discretization functions: linear, fisheye, visual fisheye, and clustered. The fisheye discretization dynamically modifies the range of pressure values based on the position of the pressure cursor. Our results show that a fisheye function results in significantly lower error rates and a lower number of crossings than have been reported in the literature. Furthermore, the fisheye function improves control without compromising speed. We discuss the findings of our study and identify several design recommendations for integrating pressure control into common interface tasks.
Core Extirpation and Zygoma Reduction: A New Surgical Approach for Fibrous Dysplasia of Zygomaticomaxillary Region (2021)

In this article, we present our experiences in the management of FD using the core extirpation with or without zygoma reduction, focusing on surgical indication, techniques, and results. Although there are limitations due to selective operative indication, the procedure can be usefully performed to prevent external growth and avoid repetitive surgery.
Development of acrylate‐based monolithic stationary phases for electrochromatographic separations (2005)

Organic monolithic stationary phases were synthesized in fused-silica capillaries. They were prepared by in situ polymerization under UV irradiation of various alkyl acrylates, 1,3-butanediol diacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in a ternary porogenic solvent. The resulting stationary phases were tested in CEC. The influence of UV irradiation energy on the resulting separative performances of the monoliths was studied. It was thus demonstrated that the use of hexyl acrylate rather than butyl acrylate and lauryl methacrylate gives highly efficient monoliths (more than 300 000 plates per meter) with optimized EOF. It was also confirmed that the mobile phase ionic strength may affect significantly the separation efficiency. The influence of the nature of the mobile phase organic modifier (ACN or methanol) on EOF, retention, efficiency, and selectivity was studied and differences were observed. Finally, the performances of monolithic stationary phases developed and optimized for CEC separations were evaluated in nanoLC.
Intraflagellar transport molecules in ciliary and nonciliary cells of the retina (2010)

The assembly and maintenance of cilia require intraflagellar transport (IFT), a process mediated by molecular motors and IFT particles. Although IFT is a focus of current intense research, the spatial distribution of individual IFT proteins remains elusive. In this study, we analyzed the subcellular localization of IFT proteins in retinal cells by high resolution immunofluorescence and immunoelectron microscopy. We report that IFT proteins are differentially localized in subcompartments of photoreceptor cilia and in defined periciliary target domains for cytoplasmic transport, where they are associated with transport vesicles. IFT20 is not in the IFT core complex in photoreceptor cilia but accompanies Golgi-based sorting and vesicle trafficking of ciliary cargo. Moreover, we identify a nonciliary IFT system containing a subset of IFT proteins in dendrites of retinal neurons. Collectively, we provide evidence to implicate the differential composition of IFT systems in cells with and without primary cilia, thereby supporting new functions for IFT beyond its well-established role in cilia.
On the mechanism of skin wound "contraction": a granulation tissue "knockout" with a normal phenotype. (1995)

This report explores the mechanism of spontaneous closure of full-thickness skin wounds. The domestic pig, often used as a human analogue for skin wound repair studies, closes these wounds with kinetics similar to those in the guinea pig (mobile skin), even though the porcine dermis on the back is thick and nearly immobile. In the domestic pig, as in the guinea pig, daily full-thickness excisions of the central granulation tissue up to but not including the wound edges in both back and flank wounds do not alter the rate or completeness of wound closure or the final pattern of the scar. A purse-string mechanism of closure was precluded by showing that surgical interruption of wound edge continuity does not alter closure kinetics or wound shape. We conclude that "tightness" of skin is not a key factor nor is the central granulation tissue required for normal wound closure. These data imply that in vitro models such as contraction of isolated granulation tissue or of the cell-populated collagen lattice may not be relevant for understanding the cell biology of in vivo wound closure. Implications for the mechanism for wound closure are discussed.
Intramolecular electronic-to-vibrational energy conversion in NO trapped in Xe matrices (1988)

Energy- and time-resolved IR emission spectra of NO trapped in Kr and Xe matrixes following excitation by an ArF laser were recorded. In Kr matrixes, the ground-state levels are predominantly populated by radiative decay from the a 4P state. The Xe matrixes ground-state v - v - 2 IR emission bands were obsd. for v = 22-3, confirming that in the NO/Xe system most of the excited-state energy is dissipated nonradiatively into the ground state. The IR bands show typical radiative decay times in the ms range but in Xe for all measured levels (v = 22-15), the rise time is ?1 ms. The nonradiative decay of the excited states to the ground state of NO in Xe matrixes is highly nonresonant. [on SciFinder (R)]
Do story agents use rocking chairs? The theory and implementation of one model for computational narrative (1996)

Narrative structure models are useful tools for understanding how and why narratives of any medium affect an audience’s level of participation in their role of story reconstruction and understanding. [14] With the advent of the computer comes the potential to negotiate through many such models and variables within models as a means of generating multiple narratives quickly and semi-autonomously. The computational narrative model presented in this paper offers one approach to narrative generation, that of splitting the task into three functional areas: 1) defining an abstract narrative structure; 2) defining a collection and organization of story pieces with some representation of their meaning; and 3) a navigational strategy or reasoning through that collection of story pieces. Agent Stories is a story design and presentation environment for non-linear, multiple-point-ofview cinematic stories. It is designed to be placed in the hands of the non-linear story writer to use as a tool to promote structuring and re-writing of non-linear narratives before and as they are realized in audio and video.
Muscular Strength and Endurance Responses to Eccentric-Enhanced Resistance TVaining (2007)

Traditional (TRAD) resistance training involves equal loading during the concentric and eccentric phases. Whereas eccentric-enhanced (ECC+) resistance training involves concentric and overloaded eccentric muscle actions, and purportedly results in greater muscle strength and mass than TRAD. PURPOSE: To test the hypothesis that ECC+ would result in greater muscle performance outcomes than TRAD after a five-week progressive resistance training program. METHODS: Twenty-two previously untrained males (22.1 ± 0.8 yrs) were randomized into training volume matched TRAD (4 sets × 6 reps at 52.5% 1RM) or ECC+ (3 sets × 6 reps at 40% 1RM concentric and 100% 1RM eccentric) groups. Participants performed chest press and squat exercise (3 × week-1) for five weeks. Training loads were increased for subsequent sessions upon successful completion of assigned repetitions. Chest and leg muscle strength [one repetition maximum (1RM)] and endurance (repetitions to fatigue) were assessed before and after the intervention. RESULTS: Muscle performance measures were similar between groups at baseline. Following the intervention, chest press (+10.1 % TRAD; +9.0% ECC+) and squat (+25.4% TRAD; +18.6% ECC+) muscle strength and chest press (+8.9% TRAD; +9.1% ECC+) and squat (+21.7% TRAD; +19.4% ECC+) endurance increased similarly between groups, respectively. Although matched at the onset of training, the total training volume over five-weeks was greater in the TRAD than the ECC+ group (83037 ± 4082 kg vs. 72458 ± 3164 kg, p<0.05), respectively. CONCLUSIONS: ECC+ may be a more efficient mode of training than TRAD, as muscle performance responses were similar between groups despite a lower total training volume in the ECC+ group.