gebhart/patrepeval huggingface dataset:
Quantitative-ultrasound detection of cancer in human lymph nodes based on support vector machines (2014)

Histological assessment of lymph nodes excised from cancer patients suffers from an unsatisfactory rate of false-negative determinations. We are evaluating high-frequency quantitative ultrasound (QUS) to detect metastatic regions in lymph nodes freshly excised from cancer patients. Three-dimensional (3D) RF data were acquired from 289 lymph nodes of 82 colorectal-, 15 gastric-, and 70 breast-cancer patients with a custom scanner using a 26-MHz, single-element transducer. Following data acquisition, individual nodes underwent step-sectioning at 50-µm to assure that no clinically significant cancer foci were missed. RF datasets were analyzed using 3D regions-of-interest that were processed to yield 13 QUS estimates including spectral-based and envelope-statistics-based parameters. QUS estimates are associated with tissue microstructure and are hypothesized to provide contrast between non-cancerous and cancerous regions. Leave-one-out classifications, ROC curves, and areas under the ROC (AUC) were used to compare the performance of support vector machines (SVMs) and step-wise linear discriminant analyses (LDA). Results showed that SVM performance (AUC = 0.87) was superior to LDA performance (AUC = 0.78). These results suggest that QUS methods may provide an effective tool to guide pathologists towards suspicious regions and also indicate that classification accuracy can be improved using sophisticated and robust classification tools. [Supported in part by NIH grant CA100183.]
2P1-D36 Segmentation of Assembly Tasks According to Force Control Parameters Applicable to Each Sub-Task (2006)

The objective of this study is to develop a design method of robot motion for complicated assembly. It is important to change the force control parameters along the task process. For complicated assembly, however, analytical approaches to detecting the change point of control parameters cannot be applicable. Thus, the whole assembly task is divided into the least number of sub-tasks, which are achieved by constant control parameters, based on human demonstration. In this paper, we briefly introduce the whole concept of the design method utilizing human skill and discuss the task segmentation.
Efficient hierarchical identity based encryption scheme in the standard model over lattices (2016)

Using lattice basis delegation in a fixed dimension, we propose an efficient lattice-based hierarchical identity based encryption (HIBE) scheme in the standard model whose public key size is only (dm 2 + mn) log q bits and whose message-ciphertext expansion factor is only log q, where d is the maximum hierarchical depth and (n, m, q) are public parameters. In our construction, a novel public key assignment rule is used to averagely assign one random and public matrix to two identity bits, which implies that d random public matrices are enough to build the proposed HIBE scheme in the standard model, compared with the case in which 2d such public matrices are needed in the scheme proposed at Crypto 2010 whose public key size is (2dm 2 + mn +m) log q. To reduce the message-ciphertext expansion factor of the proposed scheme to log q, the encryption algorithm of this scheme is built based on Gentry’s encryption scheme, by which m 2 bits of plaintext are encrypted into m 2 log q bits of ciphertext by a one time encryption operation. Hence, the presented scheme has some advantages with respect to not only the public key size but also the message-ciphertext expansion factor. Based on the hardness of the learning with errors problem, we demonstrate that the scheme is secure under selective identity and chosen plaintext attacks.
Wave enhanced transport in an arc discharge (1974)

Enhanced particle transport due to a rotational flute instability in the plasma surrounding a hollow-cathode discharge was studied. The effect of enhanced transport on the plasma density profile was measured as a function of instability amplitude by changing potentials on end-ring boundaries. 'End-ring stabilization' was observed to reduce enhanced transport by two orders of magnitude by reducing the radial electric field which drives the instability. The shape of the density profile could be explained by including enhanced transport in a simple diffusion theory by a cylindrical plasma with conducting boundaries.
In Vivo Assessment of Gene Delivery to Keratinocytes by Lentiviral Vectors (2002)

For skin gene therapy, introduction of a desired gene into keratinocyte progenitor or stem cells could overcome the problem of achieving persistent gene expression in a significant percentage of keratinocytes. Although keratinocyte stem cells have not yet been completely characterized and purified for gene targeting purposes, lentiviral vectors may be superior to retroviral vectors at gene introduction into these stem cells, which are believed to divide and cycle slowly. Our initial in vitro studies demonstrate that lentiviral vectors are able to efficiently transduce nondividing keratinocytes, unlike retroviral vectors, and do not require the lentiviral accessory genes for keratinocyte transduction. When lentiviral vectors expressing green fluorescent protein (GFP) were directly injected into the dermis of human skin grafted onto immunocompromised mice, transduction of dividing basal and nondividing suprabasal keratinocytes could be demonstrated, which was not the case when control retroviral vectors were used. However, flow cytometry analysis demonstrated low transduction efficiency, and histological analysis at later time points provided no evidence for progenitor cell targeting. In an alternative in vivo method, human keratinocytes were transduced in tissue culture (ex vivo) with either lentiviral or retroviral vectors and grafted as skin equivalents onto immunocompromised mice. GFP expression was analyzed in these human skin grafts after several cycles of epidermal turnover, and both the lentiviral and retroviral vector-transduced grafts had similar percentages of GFP-expressing keratinocytes. This ex vivo grafting study provides a good in vivo assessment of gene introduction into progenitor cells and suggests that lentiviral vectors are not necessarily superior to retroviral vectors at introducing genes into keratinocyte progenitor cells during in vitro culture.
Field-effect-assisted photoconductivity in PbS films deposited on silicon dioxide (2002)

Lead sulfide (PbS) thin films were deposited from a chemical bath onto SiO2/Si (n-type) substrates. Pseudo-metal–oxide–semiconductor devices were obtained by evaporating source and drain gold electrodes on a PbS surface and aluminum gate electrode on a Si substrate. Field-effect-assisted photoconductivity in the PbS layer was investigated at room temperature, in the 800–2700-nm-wavelength domain for different values and polarities of the drain and gate voltages. The best results were obtained for a positive gate, when both semiconductors are in depletion. An enhancement of about 25% of the photoconductive signal is obtained compared with the case when the gate electrode is absent or is not used. A simple model is proposed that explains the behavior of the dark current and photoconductive signal in PbS film with changing the gate voltage.
Effect of apolipoprotein E genotype on lipid levels and response to diet in familial hypercholesterolemia. (2000)

The response of plasma lipids to dietary fat and cholesterol is partly genetically controlled. Apolipoprotein (Apo) E polymorphism has been shown to influence basal plasma lipid levels and the response to dietary changes in normolipidemic individuals. In general, subjects carrying the E4 allele have higher basal total and low density lipoprotein cholesterol (LDL-C) plasma levels and show an increased LDL-C response to dietary manipulation. The response to diet in subjects with familial hypercholesterolemia (FH) is also variable, but the influence of apo E genotypes on their dietary response has received little attention. We studied such influence on the lipid response to the National Cholesterol Education Program type I (NCEP-I) diet in 69 FH heterozygotes (44 women and 25 men). Subjects were studied at baseline (after consuming for 1 month a diet with 35% fat [10% saturated] and 300 mg cholesterol) and after 3 months of consuming a low-fat diet. No sex-related differences were found, and results were combined for men and women. The frequency distribution of apo E alleles was similar to that described in the general Spanish population: 0.0724 for the E2 allele, 0.0724 for E4 and 0.8551 for E3. Baseline plasma lipid and lipoprotein values were not influenced by apo E genotype. The response to the NCEP-I diet was similar in all subjects and no apoE allele-related differences were identified. As in non-FH subjects, there was a nonsignificant trend towards greater LDL-C lowering in E4 (-19.3%) than in E3 (-18.2%), and E2 (-16.6%) carriers. This finding supports the hypothesis that the impact of genetic defects at the low density lipoprotein receptor (LDLR) locus in FH subjects prevails over any influence on the part of ApoE polymorphism.
Shared Gene Targets of the ATF4 and p53 Transcriptional Networks (2023)

The master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the p53 network is common in cancer, often through mutations that inactivate p53 or other members of the pathway. Induction of tumor-specific cell death by restoration of p53 activity without off-target effects has gained significant interest in the field. In this study, we explore the gene regulatory mechanisms underlying a putative anticancer strategy involving stimulation of the p53-independent integrated stress response (ISR). Our data demonstrate the p53 and ISR pathways converge to independently regulate common metabolic and proapoptotic genes. We investigated the architecture of multiple gene regulatory elements bound by p53 and the ISR effector ATF4 controlling this shared regulation. We identified additional key transcription factors that control basal and stress-induced regulation of these shared p53 and ATF4 target genes. Thus, our results provide significant new molecular and genetic insight into gene regulatory networks and transcription factors that are the target of numerous antitumor therapies.
Numerical analysis of thermomagnetic generators (1984)

Thermomagnetic generators allow direct conversion of heat energy to electrical energy. Temperature cycling about or near the Curie temperature causes changes in magnetization, resulting in time variant magnetic flux and induced voltage in a surrounding conductor. Numerical analyses of regenerative thermomagnetic generators with perfect regeneration have been performed for three working materials: iron, gadolinium, and Ho69Fe31. Power density above 20 W/kg of shunt material and efficiency approaching Carnot limits are possible over temperature differences of 50 K. Analytical studies performed during the 1950s predicted maximum power density less than 7 W/kg and efficiency less than 1% for nonregenerative cycles.
Le Tournant des Lumières (2012)

Le tournant des Lumières est le creuset des temps modernes. De l'esthétique à l'histoire des sciences, aucun champ ne sort indemne de bouleversements qui donnent aux individus l'impression que l'histoire s'accélère, que l'inédit devient banal, que les valeurs s'inversent. Chacun peut compter ou être englouti, dans un univers qui jette ses derniers feux ou inaugure une aube nouvelle dont la littérature se fait souvent l'écho. Les meilleurs spécialistes évoquent ici les interrogations et les enjeux de l'époque.
Herbivore nutrition supporting sustainable intensification and agro-ecological approaches (2018)

International audience
A statistical observation model for noisy reverberant speech features and its application to robust ASR (2012)

In this work, an observation model for the joint compensation of noise and reverberation in the logarithmic mel power spectral density domain is considered. It relates the features of the noisy reverberant speech to those of the non-reverberant speech and the noise. In contrast to enhancement of features only corrupted by reverberation (reverberant features), enhancement of noisy reverberant features requires a more sophisticated model for the error introduced by the proposed observation model. In a first consideration, it will be shown that this error is highly dependent on the instantaneous ratio of the power of reverberant speech to the power of the noise and, moreover, sensitive to the phase between reverberant speech and noise in the short-time discrete Fourier domain. Afterwards, a statistically motivated approach will be presented allowing for the model of the observation error to be inferred from the error model previously used for the reverberation only case. Finally, the developed observation error model will be utilized in a Bayesian feature enhancement scheme, leading to improvements in word accuracy on the AURORA5 database.
Dissecting DNA hypermethylation in cancer (2010)

There is compelling evidence to support the importance of DNA methylation alterations in cancer development. Both losses and gains of DNA methylation are observed, thought to contribute pathophysiologically by inactivating tumor suppressor genes, inducing chromosomal instability and ectopically activating gene expression. Lesser known are the causes of aberrant DNA methylation. Recent studies have pointed out that intrinsic gene susceptibility to DNA methylation, environmental factors and gene function all have an intertwined participation in this process. Overall, these data support a deterministic rather than a stochastic mechanism for de novo DNA methylation in cancer. In this review article, we discuss the technologies available to study DNA methylation and the endogenous and exogenous factors that influence the onset of de novo methylation in cancer.
Les cyberattaques ne sont plus ce qu’elles étaient (2020)

info:eu-repo/semantics/published
Adiponectin in essential hypertension. (2003)

Adiponectin (ADPN), the gene product of apM1, is the most abundant secretory protein of adipose tissue in human plasma. Synthesis of this substance may be reduced in endothelial dysfunction and cardiovascular diseases in humans. We investigated the relationship between plasma ADPN, body mass index (BMI), fat mass (BIA) and renal function in 36 patients with uncomplicated essential hypertension. Plasma ADPN was higher in hypertensive patients than in normotensive subjects, but the difference just failed to reach statistical significance (P=0.06). Hypertensive men had significantly higher plasma ADPN than normotensive men (6.7+/-2.6 vs 4.8+/-2.0 microg/mL, 40%, P=0.01). By contrast, the difference between hypertensive (8.5+/-3.9 microg/mL) and normotensive women (7.1+/-2.6 microg/mL) was not significant (20%). In hypertensive patients, plasma ADPN was inversely related to creatinine clearance and tended to be inversely related to serum insulin (r= -0.27) and HOMA-R index (r= -0.24). The relationship between plasma ADPN and renal function was confirmed in a multiple regression analysis which showed that creatinine clearance was the only independent predictor of plasma ADPN. Plasma ADPN in essential hypertension is dependent on sex and renal function. High levels in essential hypertensives may be the expression of a counter-regulatory response aimed at mitigating endothelial damage and cardiovascular risk associated with high arterial pressure.
Transfer of a Mycobacterium tuberculosis Genotyping Method, Spoligotyping, from a Reverse Line-Blot Hybridization, Membrane-Based Assay to the Luminex Multianalyte Profiling System (2004)

Spoligotyping using Luminex technology was shown to be a highly reproducible method suitable for high-throughput analysis. Spoligotyping of 48 isolates using the traditional membrane-based assay and the Luminex assay yielded concordant results for all isolates. The Luminex platform provides greater flexibility and cost effectiveness than the membrane-based assay.
ChemInform Abstract: Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. Part 4. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Benzimidazole Derivatives (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel approach to the sensing of liquid density using a plastic optical fibre cantilever beam (2008)

This article reports for the first time the use of a plastic optical fibre (POF) cantilever beam to measure the density of a liquid. The sensor is based on the Archimedes buoyancy principle. The sensor consists of a POF bonded on the surface of a metal beam in the form of a cantilever configuration, and at the free end of the beam a displacer is attached. Due to the apparent loss of the true weight of the displacer there is a deflection in the cantilever beam, which causes macro bending in the POF. The loss of intensity due to macro bending of the POF is a measure of the density of the liquid under test. The variation of weight loss with the density of different liquids showed that the weight loss is proportional to density. This sensor is capable of detecting the weight loss with respect to their densities even for liquids having close values of density like distilled water, tap water, and milk of various brands. The resolution of the sensor is observed to be 1.1 mg cm−3.
Synthesis and Spectroscopic Characterization of [5-13C]- and [6-13C]Ubiquinone-10 for Studies of Bacterial Photosynthetic Reaction Centers (2002)

This paper presents the synthesis and characterization by mass spectrometry and NMR spectroscopy of [2-13C]- and [3-13C]ubiquinone-0 and of [5-13C]- and [6-13C]ubiquinone-10. A scheme based on the synthetic approach to [5-13C]ubiquinone-10 has been worked out for the synthesis of ubiquinones 13C-labeled at any individual position and at every combination of positions in the quinone ring. The [5-13C]- and [6-13C]ubiquinone-10 isotopomers were incorporated into the QA-site of the photosynthetic reaction center of Rhodobacter sphaeroides R-26. Magic angle spinning NMR subsequently revealed an unperturbed 6-position, while the signal of the 5-position was absent. These results corroborate the recently reported detection of an asymmetric binding of QA with a dynamic perturbation involving the 4-carbonyl functionality.
Substituted arylimino derivatives of gossypol (1956)

Summary Seventeen substituted arylimino derivatives of gossypol have been prepared and characterized. Fifteen of these are new compounds. o ‐Nitroaniline gave both a mono‐ and a disubstituted derivative with gossypol while p,p′ ‐methylenedianiline gave only a monosubstituted derivative. During experiments designed to prevent color reversion in stored, crude cottonseed oils by treatment with various aromatic amines, only p ‐aminobenzoic acid formed an oil‐insoluble derivative with the gossypol in the oils.
Adenovirus-Mediated Expression of Dominant Negative Fibroblast Growth Factor (FGF) Receptor 1 in Thyroid Cells Blocks FGF Effects and Reduces Goitrogenesis in Mice (2003)

Levels of fibroblast growth factor 2 (FGF-2) and its receptor, FGFR1, are elevated in goiter, but whether this is a direct effect of TSH is unknown. We have determined the regulation of FGF-2 and FGFR1 synthesis by TSH in a rat thyroid cell line (FRTL5) and have used a replication-defective adenovirus (RAd) expressing dominant negative FGFR1 (RAdDN-FGFR1) to examine the role of FGFR signaling in vitro and in goiter induced in mice. TSH induced FGF-2 and increased the expression of FGFR1 in FRTL5 cells. Infection of TSH-stimulated FRTL5 cells with RAdDN-FGFR1 inhibited growth and prevented FGF-2-mediated inhibition of (125)I uptake. Similar effects were found in primary cultures of human thyroid follicular cells. For in vivo experiments, male BALB/c mice were injected systemically with RAdDN-FGFR1 or RAd encoding green fluorescent protein, and goiter was simultaneously induced. Mouse thyroid follicles were shown to be transduced with RAd encoding green fluorescent protein. Circulating TSH was elevated comparably in the two groups. In the RAdDN-FGFR1-injected animals, goiter induced over 14 d was significantly smaller, and the vascular volume increase seen in goiter was also diminished. We conclude that the FGF axis is important in thyroid growth and that RAdDN-FGFR1 effectively blocks FGF actions, offering a means to control goitrogenesis.
Eye typing off the shelf (2004)

The goal of this work is using off-the-shelf components for gaze-based interaction, with focus on eye typing. Avoiding the use of dedicated hardware such as IR light emitters makes eye tracking significantly more difficult and requires robust methods capable of handling large changes in image quality. We employ an active-contour method to obtain robust iris tracking. The main strength of the method is that the contour model avoids explicit feature detection: contours are simply assumed to remove statistical dependencies on opposite sides of the contour. The contour model is utilized in an approach combining particle filtering with the EM algorithm. The method is robust against light changes and camera defocusing. For the purpose of determining where the user is looking calibrations is usually needed. The number of calibration points used in different methods varies from a few to several thousands, depending on the prior knowledge used on the setup and equipment We examine basic properties of gaze determination when the geometry of the camera, screen and user is unknown. In particular we present a lower bound on the number of calibration points needed for gaze determination on planar objects, and we examine degenerate configurations. Based on this lower bound we apply a simple calibration procedure, to facilitate button selections for fast on-screen typing.
MDM Transmission Using Air-Clad Photonic Lanterns (2020)

MIMO less few mode transmission is performed using two spatial channels transmitted through 1 km of two mode graded index fiber at 10 Gb/s modulation rate. The multiplexing and de-multiplexing of the spatial channels are done using air clad photonic lanterns. The power in the two degenerate LP11 modes are added electrically and counted as a single channel. The Q values calculated for the LP01 and LP11 channels are 5.4 and 4.7 respectively. We also show that, the signal degradation due to modal interference can be mitigated by using different laser sources for different spatial channels with some wavelength spacing. The wavelength separation increases the modal beat frequency beyond the detector bandwidth, thus improving the transmission performance. Using two laser sources with a wavelength spacing of 0.2 nm between the spatial modes could improve the Q compared to the case where a single laser source is split between the spatial channels with some extra length of fiber in one of the paths for optical decorrelation.
High-Temperature Batteries (1969)

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