gebhart/patrepeval huggingface dataset:
Akt1 Is Essential for Postnatal Mammary Gland Development, Function, and the Expression of Btn1a1 (2011)

Akt1, a serine-threonine protein kinase member of the PKB/Akt gene family, plays critical roles in the regulation of multiple cellular processes, and has previously been implicated in lactation and breast cancer development. In this study, we utilized Akt1+/+ and Akt1-/- C57/Bl6 female mice to assess the role that Akt1 plays in normal mammary gland postnatal development and function. We examined postnatal morphology at multiple time points, and analyzed gene and protein expression changes that persist into adulthood. Akt1 deficiency resulted in several mammary gland developmental defects, including ductal outgrowth and defective terminal end bud formation. Adult Akt1-/- mammary gland composition remained altered, exhibiting fewer alveolar buds coupled with increased epithelial cell apoptosis. Microarray analysis revealed that Akt1 deficiency altered expression of genes involved in numerous biological processes in the mammary gland, including organismal development, cell death, and tissue morphology. Of particular importance, a significant decrease in expression of Btn1a1, a gene involved in milk lipid secretion, was observed in Akt1-/- mammary glands. Additionally, pseudopregnant Akt1-/- females failed to induce Btn1a1 expression in response to hormonal stimulation compared to their wild-type counterparts. Retroviral-mediated shRNA knockdown of Akt1 and Btn1a1 in MCF-7 human breast epithelial further illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ß-casein, a gene that encodes for milk protein. Overall these findings provide mechanistic insight into the role of Akt1 in mammary morphogenesis and function.
Application of Bayesian networks to multitarget tracking (1990)

This paper describes an application of Bayesian Networks, or Influence Diagrams, to the multitarget tracking problem of a single, angles only, scanning sensor. The Bayesian Network combines the continuous track state vectors and discrete report-to-track association hypotheses into one network which is then used to perform track state vector prediction and update, and to generate, score and prune association hypotheses. The advantages of operating on the network are discussed via an example in which a track resolves into two tracks. The example demonstrates that the network operations provide a highly flexible, numerically stable, computationally efficient. mechanism for calculating the state vectors, covariances and intertrack correlations of the resolved tracks. It is shown that these intertrack correlations, which are somewhat cumbersome to maintain in the usual track filter formulations, are automatically maintained in the network formulation and can improve track accuracy and resolution.
Interaction between the gut microbiome and mucosal immune system (2017)

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.
Apolarity, Hessian and Macaulay Polynomials (2013)

A result by Macaulay states that an Artinian graded Gorenstein ring R of socle dimension one and socle degree δ can be realized as the apolar ring of a homogeneous polynomial g of degree δ in x 0, ⋅, x n . If R is the Jacobian ring of a smooth hypersurface f(x 0, ⋅, x n ) = 0, then δ is equal to the degree of the Hessian polynomial of f. In this article we investigate the relationship between g and the Hessian polynomial of f, and we provide a complete description for n = 1 and deg(f) ≤4 and for n = 2 and deg(f) ≤3.
Optimal Conditions for Popping Amaranth Seeds (2009)

Amaranth seeds can be popped under suitable heating conditions. On the basis of experimental results obtained in our laboratory, we have developed a prototype of a continuous processing system for commercial application. In addition, the effects of gas temperature, flow rate, and feed speed on the popping quality of seeds, such as their volume expansion ratio and yield, were examined. The experimental results showed that the undersized yield ratio increased with the flow speed, whereas it decreased with an increase in the gas temperature. In addition, to achieve a high expansion ratio and maximum output, the feed speed was increased with the gas temperature. Furthermore, measuring the differential pressure in the test section of the experimental apparatus enabled the estimation of the quantity of seeds therein during the popping experiment.
Exposure to Pesticides as Risk Factor for Non-Hodgkin's Lymphoma and Hairy Cell Leukemia: Pooled Analysis of Two Swedish Case-control Studies (2002)

Increased risk for non-Hodgkin's lymphoma (NHL) following exposure to certain pesticides has previously been reported. To further elucidate the importance of phenoxyacetic acids and other pesticides in the etiology of NHL a pooled analysis was performed on two case-control studies, one on NHL and another on hairy cell leukemia (HCL), a rare subtype of NHL. The studies were population based with cases identified from cancer registry and controls from population registry. Data assessment was ascertained by questionnaires supplemented over the telephone by specially trained interviewers. The pooled analysis of NHL and HCL was based on 515 cases and 1141 controls. Increased risks in univariate analysis were found for subjects exposed to herbicides (OR 1.75, CI 95% 1.26-2.42), insecticides (OR 1.43, CI 95% 1.08-1.87), fungicides (OR 3.11, CI 95% 1.56-6.27) and impregnating agents (OR 1.48, CI 95% 1.11-1.96). Among herbicides, significant associations were found for glyphosate (OR 3.04, CI 95% 1.08-8.52) and 4-chloro-2-methyl phenoxyacetic acid (MCPA) (OR 2.62, CI 95% 1.40-4.88). For several categories of pesticides the highest risk was found for exposure during the latest decades before diagnosis. However, in multivariate analyses the only significantly increased risk was for a heterogeneous category of other herbicides than above.
Data for: The effects of zinc supplementation on primary human retinal pigment epithelium (2018)

These table contain the fill proteomics data for the apepr by Po-Jung at al submitted JTEMB.
Ultrafast Dynamics and Computational Studies on Diaminodicyanoquinodimethanes (DADQs) (2014)

Three diaminodicyanoquinodimethanes, 4-(R(1)R(2)C)-1-[(NC)2C]-C6H4 (R(1),R(2) = H2N, 1; R(1) = 3,5-Me2-4-OCH4H6N-, R(2) = H2N, 2; R(1) = 3,5-Me2-4-OCH4H6N-, R(2) = 4-Me-C5H9N, 3), were investigated using carbon-13 NMR, steady-state, and ultrafast transient absorption and ultrafast fluorescence spectroscopies to unravel the unusual characteristics of this class of chromophores. Computed (GIAO)B3LYP/6-31G* data for the zwitterions 1-3 using necessary solvation (PCM) models were shown to be in excellent agreement with observed structural and carbon-13 NMR data. The ground-state geometries of 1-3 contain a cationic methine group R(1)R(2)C- twisted from the C6H4 ring and an anionic methine group (NC)2C- in plane with the C6H4 ring in solution and solid state. The (13)C chemical shifts of the peak corresponding to the methine carbon at the (NC)2C- group of 1-3 are observed at 32.5-34.7 ppm, which are some 55 ppm upfield compared with the (13)C chemical shift for the methine carbons in TCNQ, 1,4-[(NC)2C]2-C6H4. The decay of the excited state in diaminodicyanoquinodimethanes is fast and dominated by nonradiative processes on the picosecond time scale, which depends on the viscosity of the medium. The dynamics of the excited-state decay is therefore limited by conformational changes through an intramolecular twisting motion. This twisting motion is hindered by friction, which, in turn, also depends on the functional group size of the system. The dominant nonradiative pathways after excitation are due to twisted excited-state conformers according to TD-DFT computations.
Serum antibody to Pseudomonas aeruginosa exotoxin measured by a passive hemagglutination assay (1977)

A passive hemagglutination (PHA) assay for antibody to Pseudomonas aeruginosa exotoxin is described which utilizes chromic chloride-treated ovine erythrocytes coated with purified toxin. PHA antitoxin titers correlated well with those obtained by a cytotoxicity neutralization assay (r = 0.91, P less than 0.001), whereas the PHA assay was four to eight times as sensitive. The mean serum PHA titer of 16 patients convalescing from recent pseudomonas infections (log2 = 9.4 +/- 3.9) was significantly higher (P less than 0.001) than that of 17 healthy controls (2,7 +/- 2.6), and fourfold or greater rises were demonstrated in 5 of 7 patients examined sequentially. The lower levels of PHA antibody in sera from 11 of 17 controls suggested the acquisition of antitoxin secondary to asymptomatic infection.
Red blood cell minor antigen mismatches during chronic transfusion therapy for sickle cell anemia (2017)

Alloimmunization incidence was higher in those with prior RBC antibodies, suggesting that past immunologic responders are at higher risk for future alloimmunization and therefore may benefit from more extensive antigen matching beyond C/c, E/e, K, Fy<sup>a</sup> , and Jk<sup>b</sup> .
Pareto-Improving Pricing Schemes for Route Assignment of Heterogeneous Users (2020)

Traffic congestion constitutes a major problem in commercial areas having negative effects on travel times, fuel consumption and other operational costs. Additionally, the continuously increasing use of GPS technologies has made drivers to make routing decisions in an effort to minimize their own individual travel time which is known to lead to an inefficient road usage. In this paper, we propose a novel pricing scheme to alleviate traffic congestion by controlling the freight routing decisions through a coordination mechanism. The proposed mechanism asks the truck drivers to declare their Origin-Destination (OD) pair and their individual Value Of Time (VOT) and guarantees that every participant truck driver will be better-off compared to the User Equilibrium (UE) by providing them individual incentives to truthfully declare their VOT while leading to a budget balanced on average mechanism. The optimum route assignment and the resulting pricing scheme can be calculated by solving a nonconvex optimization problem. To reduce the dimensionality of the problem, we propose a second pricing scheme and we prove that satisfies the aforementioned characteristics. Finally, the evaluation of our approach using the Sioux Falls network shows that the proposed pricing schemes can make the network approach the System Optimum (SO) solution.
3079 Another Skeleton in the Hospital Closet (2019)

INTRODUCTION: Nutrition is vital for the care of critically ill patients in the hospital. Malnutrition in the hospital setting was first introduced in 1974, illustrating that 50% of patients in urban hospitals are malnourished. Despite this historical finding and advance in medicine, there remains a delay in screening for malnutrition and providing adequate care for this population. We present a case of a young female where severe depression led to diagnostic delay of multiple nutritional deficiencies, eventually leading to her demise. CASE DESCRIPTION/METHODS: 44 year-old female with a past medical history of Lynch Syndrome s/p right hemicolectomy and severe depression who initially presented to an outside facility after involuntary commitment by her family for failure to thrive. She became severely depressed after diagnosis and lost approximately 100 lbs. At presentation, she was hypotensive and tachycardic requiring pressor support. Abdominal CT scan revealed new cirrhosis and left ureteral calculus with hydronephrosis so she underwent ureteral stent placement. She was also noted to have purpura and severe skin fragility, concerning for nutritional deficiency. Echo revealed new onset heart failure. She remained hypotensive and was transferred to our ICU for further management. Nutritional labs showed severe deficiencies in Vitamins B1, B3, B6, C, D, zinc, copper, and selenium. Despite aggressive repletion and antibiotic therapy, she remained ill. She later developed Candida peritonitis and was initiated on antifungals. Abdominal pain persisted and repeat CT Abdomen revealed pneumatosis at the site of the ileocolonic anastomosis along with loculated ascites. Exploratory laparotomy was performed but she was never able to fully recover. Her condition declined and family opted for hospice care where she eventually passed away. DISCUSSION: Despite advances in medicine and nutritional therapy, barriers remain in providing adequate care for the malnourished. Prompt recognition of patients that are at high risk for developing nutritional deficiencies and depression can prove to be life saving. Depression leading to poor nutritional intake can result in vitamin deficiencies, which themselves have been linked to depression, resulting in a vicious cycle that is difficult to escape. Supplementing diet with vitamins for one year has been shown to improve mood. Healthcare providers should understand and promptly screen for malnutrition to prevent morbidity and mortality as in the case of our patient.
5성급 호텔 연회의 선택속성이 고객만족 및 행동의도에 미치는 영향 (2016)

This study focuses on proposing efficient measures for a hotel to improve customer satisfaction and to increase its relevant ranking. In order to achieve this, the study analyzed the relationships of selected attributes of hotel banquets, customer satisfaction, and recommendation intention. This way, the study would be able to remind the hotel of how important the selected attributes of a hotel banquet are. SPSS WIN 18.0 was used for frequency analysis, main cause analysis, confidence analysis, appropriateness analysis, correlation analysis, and recurrence analysis. According to the results, facilities and service had a positive influence on customer satisfaction. For Hypothesis 2, customer satisfaction positively affected recommendation intention. Thus, satisfied customers would likely repurchase and provide positive verbal evaluation. Hence, it is suggested that thorough customer management should be conducted from the moment that the customer chooses the banquet until she or he finishes it. For Hypothesis 3, facilities and service were determined to positively influence recommendation intention. According to the results of this study, when customers are satisfied with facilities and service during the use of a banquet hall, they will use it again even if the price goes up, and their trust in service directly leads to repurchase by either actively using it again or promoting/recommending it to other people.
Anionic photocatalysts supported in layered double hydroxides: intercalation and photophysical properties of a ruthenium complex anion in synthetic hydrotalcite (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnionic photocatalysts supported in layered double hydroxides: intercalation and photophysical properties of a ruthenium complex anion in synthetic hydrotalciteEmmanuel P. Giannelis, Daniel G. Nocera, and Thomas J. PinnavaiaCite this: Inorg. Chem. 1987, 26, 1, 203–205Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/ic00248a039https://doi.org/10.1021/ic00248a039research-articleACS PublicationsRequest reuse permissionsArticle Views635Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adult mesenchymal stem cells and their potency in the cell-based therapy. (2013)

Cerebellar granule cells originate from precursors located at the dorsal region of rhombomere in the hindbrain of embryos. They undergo proliferation from embryo to post-natal period so as to form the major cell type of the cerebellum. The development of granule cell is not only highly dependent on the cerebellar intrinsic environment, but also is regulated by serials of transcription factors on different signaling pathways. Therefore, in this manuscript the signaling pathways participating in the proliferation and differentiation of granular cells during normal development was reviewed.
Spectroscopy of supersmall absorption using the technique of a phase-contrast thermal lens (1994)

The problem of measuring supersmall light absorption in materials led to the development of a high-sensitivity optothermal laser technique, thermal lens and interferometer technique being the most widely-known. An optimum combination of the two above methods has been implemented where high sensitivity of optothermal phase-contrast technique (which reached for liquid media 10<SUP>-9</SUP> cm<SUP>-1</SUP> at the pump energy 3 J) was demonstrated. The technique suggested here is quite competitive with other optothermal methods due to its simplicity of performing, absorption linearity of the measured signal and independence of the signal on absorption at the windows of the cell containing the medium under investigation.
1559. Hematopoietic Cell Transplantation with Post-transplant Cyclophosphamide: Impact of Donor Type on Pre-engraftment Blood-Stream Infections (2018)

The aim of the study was to estimate the cumulative incidence of pre-engraftment blood stream infections (PE-BSI), its predictive factors and the infection-related mortality (IRM) after hematopoietic cell transplantation (HCT) from any donor type, with post-transplant cyclophosphamide (PT-Cy). Retrospective cohort study on 235 adults who underwent peripheral blood HCT from every donor type with PT-Cy platform, from 2013 to 2017 at San Raffaele Scientific Institute. The Poisson regression was used to estimate the crude incidence rate (IR) of PE-BSI. The Fine-Gray competing risk model was applied to estimate the cumulative incidence function (CIF) of the first PE-BSI and its predictive factors and of IRM. Patients’ characteristics are reported in Table 1. During 5,316 person-days of follow-up (PDFU), 77 PE-BSI episodes occurred in 72 patients: IR = 1.45 per 100-PDFU [95% confidence interval (95% CI) 1.13–1.77]. The median time to PE-BSI was 13 days (IQR: 7–17) and the estimated CIF at 28 days was 32% (95% CI: 26–39%); no differences in CIF according to donor type [30% vs. 34% vs. 32% in match-related, match-unrelated and haploidentical donor, respectively; Gray’s test: P = 0.968]. Among the 87 isolated pathogens, 60% were Gram-positive bacteria (GPB), 39% Gram-negative bacteria (GNB) and 1% nontuberculous mycobacteria. CIFs of GNB and GPB PE-BSI by type of donor are shown in Figure 1. By multivariate analysis (Table 2), after adjustment for age, sex, year of HCT, donor type and disease phase at HCT, the CIF of any PE-BSI was higher in subjects with absolute neutrophils count ≤500 for ≥7 days before HCT [adjusted hazard ratio (AHR) = 2.90] and in multi-drug resistant (MDR) GNB rectal carriers before HCT [AHR = 2.68]. These covariates were confirmed as independent factors also for GNB PE-BSI. Overall, IRM at 30 days was 5% (95% CI: 2–8%) with no differences by donor type (Gray’s test: P = 0.106). HCT with PT-Cy platform showed a 32% of cumulative incidence of PE-BSI at 28 days and donor type did not affect its occurrence, which was conversely increased by prolonged and severe neutropenia and MDR GNB rectal carriage before HCT. Haploidentical setting did not retain a higher IRM at 30 days than match-related and match-unrelated donors. All authors: No reported disclosures.
Quench Detection and Protection of the Wide Bore 900 MHz NMR Magnet at the National High Magnetic Field Laboratory (2004)

A wide bore, high resolution NMR magnet with a proton resonance frequency of 900 MHz, field of 21.1 T, and stored energy of 40 MJ has been designed and fabricated at the NHMFL. The magnet has five Nb/sub 3/Sn and five NbTi coils, each of which contains stainless steel strip heaters. An active protection system with analog quench detection circuitry is employed to determine the onset of a quench and to subsequently open a superconducting protection switch and energize a portion of the strip heater network. A passive protection system with diode sets and shunting resistors exist for redundancy. Details of the protection system are presented and its performance during the magnet's bucket test is discussed.
Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis (2012)

Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR). Here we examined the ileum-specific effects of reducing CLR on TxA ileitis by local preinjection of double-stranded RNAs. Treatment with CLR dsRNA for 7 d decreased CLR immunoreactivity, whereas treatment with non-CLR dsRNA did not. Subsequent injection of TxA in the same location increased CLR in rats treated with non-CLR dsRNA but not in rats treated with CLR dsRNA, documenting that local injection of dsRNA is effective in preventing the increase in CLR immunoreactivity in response to local TxA. After non-CLR dsRNA pretreatment, TxA induced robust intestinal secretion, myeloperoxidase activity, and histopathologic indications of inflammation including epithelial damage, congestion, neutrophil infiltration, loss of mucin from goblet cells, and increase in mast cell numbers. After CLR dsRNA pretreatment, TxA-induced changes in intestinal secretion and histopathologic inflammation were improved, including normal mucin staining and fewer resident mast cells. Loss of CLR prevented TxA-mediated activation of NF-κB and concomitant increases in pERK1/2 and TNF-α mRNA. Locally produced CLR plays a proinflammatory role in TxA ileitis via MAPK signaling and TNF-α. The results reported here strongly suggest that a local injection of dsRNA targeting CLR could be an effective local therapeutic approach at the inflammation site in the treatment of a growing, clinically relevant hospital-acquired disease, C. difficile infection.