gebhart/patrepeval huggingface dataset:
BCL2 Negative Follicular Lymphoma with BCL6 Gene Rearrangement Show Mutations of STAT6 DNA Binding Domain (2012)

Abstract Abstract 1559 Follicular lymphoma (FL) is the most common indolent subtype of non-Hodgkin's lymphoma in the western world. The genetic hallmark of FL is the t(14;18)(q32;q21) translocation leading to the deregulation of BCL2 expression which occurs in up to 90% of the grade 1–2 FL. However, a minority of FL without BCL2 gene rearrangement harbour genetic abnormalities involving the BCL6 gene (5–15% of the cases) and show distinct pathological features. The activation of Signal Transducer and Activator of Transcription 6 (STAT-6) has been observed in Primary Mediastinal B-cell Lymphoma (PMBL) and Hodgkin Lymphoma but also in FL. Because missense mutations of STAT6 DNA binding domain have been described in PMBL, we searched for such mutations in FL. Using a PCR HRM (High Resolution Melting) assay as a screening tool and conventional Sanger sequencing in all cases with abnormal denaturation curves, we analyzed the frequency of STAT6 mutations in FL samples. We focused our screening on exon 12, which encodes part of the DNA binding domain and which had been shown to be a hotspot mutation in PMBL. A series of 40 FL lymphomas samples diagnosed at the University Hospital of Créteil (Henri Mondor) and Centre Henri Becquerel in Rouen were retrieved. These tumors showed characteristic histopathological features of FL according to the World Health Organization (WHO) classification. DNA analysis was performed on DNA extracted from fresh/frozen samples (Rouen) or FFPE (formalin-fixed and paraffin-embedded) tissues (Créteil) with standard procedures. We detected 5 (12%) mutated tumors in this series of FL. These 5 mutations were single missense mutations targeting amino acids 419–421. All mutations were observed in histological grade 1or 2 lymphomas, and no mutations were found in the 9 cases classified as 3A or 3B. Only one classical FL out of 15 cases (6%) with BCL2 rearrangement showed STAT6 mutation. Strikingly, the 4 other mutated cases showed specific features. There were 3 female and 1 male, with a mean age of 52 years, and all presented with inguinal involvement and stage III or IV Ann Arbor disease. Morphologically, these cases displayed a follicular growth pattern. The immunophenotype was CD20+, CD5-, CD10+ (3/4), BCL6+, CD23+ (3/4) but BCL2 was negative (4/4). Cytogenetically, these 4 cases were characterized by BCL6 gene rearrangement without BCL2 gene rearrangement by interphase FISH on FFPE tissue sections. Thus, STAT6 mutations were observed in 4/11 (36%) grade 1–2, and 0/6 grade 3A/3B BCL2 negative FL with BCL6 rearrangement. No case was found to be mutated in the FL group without BCL2 and BCL6 rearrangement (8 cases). In conclusion, this is the first time that mutations of STAT6 are found in FL and interestingly, they target a rare group of FL with distinct pathological and cytogenetical features. Further investigations are required to identify the mutational mechanisms involved and the oncogenic function associated with these mutations. Disclosures: No relevant conflicts of interest to declare.
Micromachining of Optical Fiber Using Reactive Ion Etching and Its Application (2000)

Reactive ion etching (RIE) experiments were performed on an optical fiber which was loaded onto an rf cathode and exposed to a low-pressure discharge of CF 4 gas. This method enables the fabrication of slender optical fibers with almost uniform diameter in specified regions, but has no significant effect on the core of the fiber which is the propagation path of the signal. An optic variable attenuator was demonstrated using glycerine as an additional cladding on a thinned optical fiber of diameter 22 µm. The glycerine temperature change of 40°C caused an attenuation of 12 dB at 1550 nm. The application of a micromachined single-mode grating fiber (10/125 µm, grating wavelength: 1550 nm) to an optical fiber sensor for detecting the refractive indices of surrounding materials was examined.
Red Wine, Toast of the Town (Again) (2013)

The debate may be over on whether resveratrol and other small molecules directly activate an enzyme implicated in longevity. [Also see Report by Hubbard et al. ]
ZoomMaps: Using Zoom to Capture Areas of Interest on Images (2019)

Eye movements can help localize the most attention-capturing, interesting, or confusing regions of images or user interfaces (Jacob & Karn, 2003). Consequently, there have been significant efforts to find more scalable alternatives for collecting user attention, including moving-window methodologies (e.g., BubbleView, see Kim, Bylinskii, et al., 2017). In this work, we propose an extension of the moving-window methodology, by taking advantage of user viewing behavior on mobile screens. A mobile screen provides a naturally restricted window to explore multiscale content with the help of the zoom functionality. In this work, we present an approach to capture zoom behavior using a mobile interface, we use the collected spatial zoom patterns as a proxy for attention that we call ZoomMaps (which can be visualized as heatmaps), and we propose applications that can be built on top of zoom data. In one set of experiments, we collected the ZoomMaps of 14 participants using our zoom interface on mobile devices with a set of natural images from the CAT2000 dataset (Borji & Itti, 2015). We found that ZoomMaps are highly correlated with image saliency and ground truth eye fixation maps. In a separate set of experiments on academic posters, 10 participants spent 30 minutes exploring 6 posters. We found that zoom data could be used to generate personalized GIFs of subjects’ viewing patterns that were more effective at eliciting subsequent memory than static thumb-nails. These experiments suggest that ZoomMaps provide an effective and natural interface for collecting coarse attention data that can be harnessed for a variety of applications. For instance, zoom can be used to measure the natural scale of visual content, to summarize visual content, or to act as a debugging tool for designs.
["Serratia marcescens" in neonatology: epidemiology of a hazard (author's transl)]. (1980)

A case of meningitis, caused by Serratia marcescens in a 6-day old newborn triggered a search for Serratia in the Neonatology ward. Fifteen out of 38 newborns were found fecal carriers of S. marcescens. The source of S. marcescens was found in flasks containing almond oil with 1% cetyltrimethylammonium bromide used for skin care. All strain of S. marcescens belonged to pigmented biotype A6a and serotype 014 : H10. The spread of S. marcescens was controlled by heat sterilizing and renewing twice a week the almond oil flasks. Means of control of contamination sources are discussed.
Newly developed diagnostic methods for SARS-CoV-2 detection (2020)

Abstract The emergence of SARS-CoV-2, responsible for COVID-19 disease, has caused a substantial worldwide pandemic and has become a significant public health problem. World Health Organization (WHO) has declared COVID-19 as a devastating health emergency for all countries. Public health officials continue to monitor the situation closely to control this new virus-related outbreak. In order to continue to manage this pandemic, a fast and sensitive diagnosis of COVID-19 is attempted. Emerging tests have become an essential part of the management of the COVID-19 crisis. This review article aims to provide a detailed explanation of ongoing and new diagnostic technologies for SARS-CoV-2 and a summary of method principles. Examples of new diagnostic methods for providing efficient and rapid diagnostic tests for managing the SARS-CoV-2 outbreak are also mentioned.
Association Between Potassium Level and Outcomes in Heart Failure with Reduced Ejection Fraction: A Cohort Study from the Swedish Heart Failure Registry (2020)

In this nationwide registry, the relationship between potassium and mortality was U-shaped, with an optimal potassium value of 4.2 mmol/L. After multivariable adjustment, hypokalaemia was associated with increased long-term mortality but hyperkalaemia was associated with increased short-term mortality.
Modélisation des oscillateurs biochimiques contrôlant la dynamique du cycle cellulaire (1997)

Doctorat en Sciences
Usage of a Graph Neural Network for Large-Scale Network Performance Evaluation (2021)

To quickly and accurately perform network evaluation, we propose a graph convolutional network-based performance evaluation method for ultralarge-scale networks. The learning results show that our method outperforms the fully connected network and convolutional neural network in the prediction error of the end-to-end latency and network throughput. In addition, we show that our method is significantly less time-consuming than traditional methods.
Abstract WP357: The Impact of Specific Neuroanatomical Location in Deep Supratentorial Intracerebral Hemorrhage (ICH): Findings From the Ethnic/Racial Variations of ICH Study (2016)

Background: Recently early phase clinical trials have targeted individual anatomical locations. However, information regarding ICH characteristics and outcomes of specific deep locations of ICH is limited. Methods: ERICH is a multi-center, prospective, case-control study of a racially mixed population with ICH. ICH locations were systematically designated by a central imaging core. Subjects with supratentorial deep ICH based on initial head CT originating in the caudate, thalamus, or putamen were included. Those with pre-morbid modified Rankin Scale (mRS) &gt; 2, positive drug screen, or missing 3-month mRS were excluded. Differences in baseline characteristics and medical interventions were examined by anatomic location, stratified by intraventricular hemorrhage (IVH) presence. Receiver operating curve analysis was performed to determine ICH volume specificity for poor outcome (mRS 4-6). Results: A total of 945 subjects met inclusion criteria for the analysis: caudate (n=62), putamen (n=394), thalamus (n=489). Significant differences were noted for presence of IVH (caudate 89%, putamen 23%, thalamus 64%, p&lt;.0001), ventriculostomy (caudate 52%, putamen 14%, thalamus 27%; p&lt;.0001), and surgery (caudate 2%, putamen 10%, thalamus 2%, p&lt;.0001). In multivariable analysis, subjects with thalamic ICH without IVH (compared with putaminal ICH without IVH) were more likely to be younger (OR 1.02; 95%CI 1.00-1.04, p=.0130, have history of hypertension (OR 2.82, 95%CI 1.24-6.39), and lower ICH volume (OR 0.28, 95%CI 0.21-0.38, p&lt;.0001). Subjects with thalamic ICH and IVH (compared with putaminal ICH and IVH) were less likely to have surgery for evacuation (OR 0.14, 95%CI 0.04-0.46, p=.0012) and have lower ICH volume (OR 0.13, 95%CI 0.08-0.22, p&lt;.0001). Receiver operating curve analysis identified 5.39 mL volume in thalamic ICH without IVH and 18.68 ml in putaminal ICH without IVH as having 95% specificity for poor outcome. Conclusion: In patients with deep supratentorial ICH, IVH is significantly more common in caudate and thalamic ICH compared with putaminal ICH. ICH volume cut-offs highly specific for poor outcome were identified. These findings may have implications for prognosis and clinical trial design.
Effectiveness of a clinical practice guideline for parenteral nutrition: a 5‐year follow‐up study in a pediatric teaching hospital (2002)

In a large pediatric tertiary care hospital, a CPG was successfully deployed. CPGs can favorably affect the use rates and costs of parenteral nutrition.
Genetic susceptibility to the endemic form of NPC (2016)

Nasopharyngeal carcinoma (NPC) is a malignancy with remarkably high prevalence in East Asia. Lines of evidence have suggested the involvement of genetic lesions in the etiology of NPC, together with the contributions of Epstein-Barr virus infection and environmental exposures. Linkage and association studies, either based on candidate genes or genome-wide levels, have been conducted to dissect the genetic variants that contribute to NPC risk. This review summarizes the current findings of genetic susceptibility to NPC, and points out some future challenges on discovery of other risk variants to explain the missing heritability of NPC.
Formic Acid Reduction. XV. Reaction of N-Methyl and N-Formyl Derivatives of p-Phenylenediamine with Formates. N-Methylation of Formanilides (1972)

Conversion of varied N-methyl and N-formyl derivatives of p-phenylenediamine to other kinds of analogous compounds with increase and decrease of N-methyl has been found to occur on heating at 175-180° with the high-boiling liquid formates composed of formic acid and trialkylamine. From investigation on this reaction the formate reagents have been introduced to affect N-methylation of formanilides in a course entirely different from the known demethylation by the same reagents.
Antennes magnéto-électriques: comment les réponses électriques et magnétiques des antennes optiques permettent de contrôler la directivité d'émission et les transitions dipolaires électriques/magnétiques d'émetteurs quantiques (2013)

National audience
Expression et role de la laminine-2 et de la laminine-5 dans la morphogenese et la differenciation de l'intestin (1997)

Nous avons analyse l'expression et tente de determiner le role physiologique dans l'intestin de deux isoformes de laminines, constituants de la lame basale. La laminine-2 est exprimee de facon restrictive dans les cryptes intestinales (compartiment proliferatif) chez l'homme comme chez la souris ; son origine cellulaire est exclusivement mesenchymateuse. L'absence de cette glycoproteine dans l'intestin de souris mutante dy n'a pas affecte la morphogenese des cryptes ni la differenciation des cellules de paneth. La laminine-5, dont l'apparition est precoce, presente un gradient d'expression qui est parallele a l'etat de differenciation des cellules epitheliales le long de la villosite. L'utilisation de cellules cancereuses coliques humaines plus ou moins differenciees ne nous a pas permis de conclure a une relation directe entre l'expression de la laminine-5 et la differenciation. Les resultats sont plutot en accord avec ceux obtenus grace au modele des intestins hybrides montrant un relai pour le depot de la chaine 2 de la laminine-5 par les cellules epitheliales indifferenciees aux stades precoces puis par les cellules mesenchymateuses aux stades tardifs de developpement. Contrairement aux keratinocytes, les cellules coliques secretent majoritairement une laminine-5 comprenant le precurseur de la chaine 2, et de la laminine-6/7. Des etudes d'adhesion cellulaire couplees a des tests de denaturation ont permis de montrer pour la premiere fois que l'integrine 21 portee par les cellules cancereuses coliques est un recepteur potentiel majeur a la laminine-5. L'analyse en microscopie confocale de l'integrine 21 montre une segregation sur laminine-5 de ce recepteur au pole basal des cellules. Les integrines 31, 61 et 64 sont egalement impliquees dans l'adhesion a ce substrat.
Selective Actions of Prolactin on Catecholamine Turnover in the Hypothalamus and on Serum LH and FSH (1976)

The effects of prolactin (PRL) administration on catecholamine turnover in various brain regions of ovariectomized rats were determined by observing the decline of dopamine and norepinephrine concentrations after alpha-methyltyrosine (alphaMT) administration. PRL had no effect on the steady state concentration of dopamine in the median eminence, anterior hypothalamus and corpus striatum or on the norepinephrine concentration in the anterior hypothalamus. However, PRL selectively enhanced dopamine turnover in the median eminence and anterior hypothalamus after a latent period of 10-26 h. In addition, PRL administration significantly decreased serum concentrations of LH and FSH. These results suggest that the PRL-induced increase in activity of dopaminergic neurons in the median eminence or anterior hypothalamus may be responsible for the reduction of the post-castration rise in serum concentrations of LH and FSH.
An Experimental Examination of the Walrasian tatonnement Mechanism (1996)

This is a systematic experimental comparison of the efficiency and competitive properties of a computerized multiunit tatonnement with or without a dynamic improvement rule, with or without publicity of order flow information. All versions of the tatonnement are comparatively less efficient than the continuous double auction. The tatonnement yields competitive prices, but both sides tend to underreveal demand/supply, causing inefficiency. Only the full-information, no-improvement-rule version of the tatonnement procedure approaches the efficiency of the double auction.
T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection withNippostrongylus brasiliensis (2000)

The IL-1 receptor-related protein T1 is expressed on the surface of Th2, but not Th1 cells. Studies with anti-T1 monoclonal antibodies have suggested that T1 is critical for development of normal Th2-type responses. To elucidate the role of T1 in vivo, we generated T1-deficient mice and a T1-transgenic strain which secretes soluble T1-Fc fusion protein into the serum. These were analyzed for the Th2 immune response induced by infection with the parasitic nematode Nippostrongylus brasiliensis. Although Th2 cytokine production by lymph node cells was similar in all groups of N. brasiliensis-infected mice, a decrease in IL-5 production by lung lymphocytes was detected in both T1-deficient and T1-Fc-transgenic mice compared to control littermates. This difference in IL-5 production did not influence blood eosinophilia, but recruitment of eosinophils into lung tissue, especially in T1-Fc-transgenic mice was slightly decreased. However, induction of all other immune parameters was normal and both T1-deficient and T1-Fc-transgenic mice were able to clear the parasite infection within 12 days with kinetics similar to those in control mice. Therefore, in contrast to previous suggestions, we conclude that the T1 protein is not obligatory for normal development of Th2 immune responses.
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. (1995)

The sensing of an odorant by an animal must be a rapid but transient process, requiring an instant response and also a speedy termination of the signal. Previous biochemical and electrophysiological studies suggest that one or more phosphodiesterases (PDEs) may play an essential role in the rapid termination of the odorant-induced cAMP signal. Here we report the molecular cloning, expression, and characterization of a cDNA from rat olfactory epithelium that encodes a member of the calmodulin-dependent PDE family designated as PDE1C. This enzyme shows high affinity for cAMP and cGMP, having a Km for cAMP much lower than that of any other neuronal Ca2+/calmodulin-dependent PDE. The mRNA encoding this enzyme is highly enriched in olfactory epithelium and is not detected in six other tissues tested. However, RNase protection analyses indicate that other alternative splice variants related to this enzyme are expressed in several other tissues. Within the olfactory epithelium, this enzyme appears to be expressed exclusively in the sensory neurons. The high affinity for cAMP of this Ca2+/calmodulin-dependent PDE and the fact that its mRNA is highly concentrated in olfactory sensory neurons suggest an important role for it in a Ca(2+)-regulated olfactory signal termination.
Software State-of-the-Art: selected papers (1991)

"Software State-of-the-Art: selected papers." European Journal of Information Systems, 1(3), pp. 221–222
Author Correction: A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A Novel Role for Murine IL-4 In Vivo: Induction of MUC5AC Gene Expression and Mucin Hypersecretion (1997)

Mucus hypersecretion and plugging of lower respiratory tract airways contributes to the morbidity and mortality associated with asthma. Interleukin (IL)-4 plays a putative role in some forms of asthma. Thus, transgenic mice that overexpress murine IL-4 selectively within the lung were used to study the effect of IL-4 on mucus glycoprotein gene expression and mucin release. Histologic examination of lung sections from IL-4 mice revealed that nonciliated epithelial cells from conducting airways were hypertrophic, due at least in part to the accumulation of mucus glycoprotein. The cytoplasm of these cells stained positively for glycoproteins using mucicarmine, alcian blue (AB), and periodic acid-Schiff (PAS). Ciliated cells were also enlarged but did not show any mucin-specific staining. Inclusion granules typically found in nonciliated (Clara) cells of control mice were absent in the IL-4 transgenic mice. Northern blot analysis of total RNA from lung tissue revealed that the expression of the MUC5AC, but not MUC2, mucin gene was distinctly upgraded in IL-4 transgenic mice compared to transgene-negative controls. In addition, a 5- to 10-fold increase in AB- and PAS-positive material was found in lavage fluid from IL-4 overexpressing mice compared to transgene-negative controls. Thus, the overexpression of IL-4 locally within the lung enhances mucus glycoprotein synthesis by altering gene expression, results in the accumulation of mucus glycoprotein in nonciliated epithelial cells, and induces the release of mucus into the airway lumen. We therefore hypothesize that the overproduction of mucus seen in some patients with asthma may be a direct result of the action of IL-4 within the inflamed lung.
Superaerophobic Ultrathin Ni–Mo Alloy Nanosheet Array from In Situ Topotactic Reduction for Hydrogen Evolution Reaction (2017)

Hydrogen evolution reaction (HER) has prospect to becoming clean and renewable technology for hydrogen production and Ni-Mo alloy is among the best HER catalysts in alkaline electrolytes. Here, an in situ topotactic reduction method to synthesize ultrathin 2D Ni-Mo alloy nanosheets for electrocatalytic hydrogen evolution is reported. Due to its ultrathin structure and tailored composition, the as-synthesized Ni-Mo alloy shows an overpotential of 35 mV to reach a current density of 10 mA cm<sup>-2</sup> , along with a Tafel slope of 45 mV decade<sup>-1</sup> , demonstrating a comparable intrinsic activity to state-of-art commercial Pt/C catalyst. Besides, the vertically aligned assemble structure of the 2D NiMo nanosheets on conductive substrate makes the electrode "superaerophobic," thus leading to much faster bubble releasing during HER process and therefore shows faster mass transfer behavior at high current density as compared with drop drying Pt/C catalyst on the same substrate. Such in situ topotactic conversion finds a way to design and fabricate low-cost, earth-abundant non-noble metal based ultrathin 2D nanostructures for electrocatalytic issues.
C-Reactive Protein Binds Leishmanial Excreted Factors (1985)

Excreted factors from Leishmania tropica and Leishmania donovani are precipitated by human and rabbit C-reactive protein. The reaction is calcium dependent and appears to be similar to that reported to occur between C-reactive protein and various galactans. The absence of phosphate and N-acetyl galactosamine suggests that the reaction is not the result of any similarity of the excreted factors to pneumococcal C-polysaccharide.