gebhart/patrepeval huggingface dataset:
5G MEC Computation Handoff for Mobile Augmented Reality (2024)

The combination of 5G and Multi-access Edge Computing (MEC) can significantly reduce application delay by lowering transmission delay and bringing computational capabilities closer to the end user. Therefore, 5G MEC could enable excellent user experience in applications like Mobile Augmented Reality (MAR), which are computation-intensive, and delay and jitter-sensitive. However, existing 5G handoff algorithms often do not consider the computational load of MEC servers, are too complex for real-time execution, or do not integrate easily with the standard protocol stack. Thus they can impair the performance of 5G MEC.To address this gap, we propose Comp-HO, a handoff algorithm that finds a local solution to the joint problem of optimizing signal strength and computational load. Additionally, Comp-HO can easily be integrated into current LTE and 5G base stations thanks to its simplicity and standard-friendly deployability. Specifically, we evaluate Comp-HO through a custom NS-3 simulator which we calibrate via MAR prototype measurements from a real-world 5G testbed. We simulate both Comp-HO and several classic handoff algorithms. The results show that, even without a global optimum, the proposed algorithm still significantly reduces the number of large delays, caused by congestion at MECs, at the expense of a small increase in transmission delay.
Effect of influenza virus infection on key metabolic enzyme activities in MDCK cells (2011)

BackgroundInfluenza, or “flu”, is an upper respiratory tract infectioncaused by a virus belonging to the family ofOrthomyxo-viridae. Influenza can pose a serious risk to the health ofmainly the elderly, the very young, and to people suffer-ing from medical conditions (e.g. weak immune system).For example, seasonal influenza strains are fatal to morethan 50,000 people annually in the United States alone[1]. The most effective measure for preventing influenza-related morbidity and mortality is annual vaccination.Seasonal influenza vaccines are almost exclusively pro-duced using the traditional egg-based manufacturing pro-cess. However, the main limitation of egg-basedtechnology (especially in the case of a pandemic) is thetime-consuming production process (~6 months).Furthermore, people with serious egg allergy cannot bevaccinated when trace amounts of egg protein remain inthe final formulation. Therefore, new production pro-cesses using continuous cell lines for influenza vaccinemanufacturing are currently being established [2].Influenza viruses take advantage of the host cell meta-bolism to replicate their genetic material and to synthe-size viral proteins. The influenza virus particle consistsof three major parts: the ribonucleocapsid, the matrixprotein M1, and the envelope, which is derived from theplasma membrane of the host cell. The lipid bilayer con-tains the ion channel protein M2 and the immunogenicglycoproteins hemagglutinin and neuraminidase [3]. Thereplication cycle of influenza viruses including entry,uncoating, genome transcription and replication, assem-bly and release has been studied extensively with type Astrains [4]. So far, only few studies have characterizedthe influence of influenza infection on the centralcarbon metabolism of host cells [5]. Madin-Darbycanine kidney (MDCK) cells are considered a suitablesubstrate for cell culture-based influenza vaccine manu-facturing [2,6]. In this study, key metabolic enzymeactivities were analyzed in MDCK cells infected with aninfluenza A virus strain to improve our understandingof virus-host cell interaction and cell response.Materials and methodsAll chemicals and enzymes were purchased from Sigma(Taufkirchen, Germany) or Roche (Mannheim, Ger-many). Adherent MDCK cells obtained from theECACC (No. 84121903) were routinely cultured in 6-well plates containing 4 mL of GMEM-based medium(2 mM glutamine, 30 mM glucose, 10 % (v/v) fetal calfserum, 2 g/L peptone, 48 mM NaHCO
INVESTIGATING THE IMPACT OF DIABETES MELLITUS ON THE OUTCOMES OF HIP FRACTURE SURGERY (2018)

The international literature base demonstrates that individuals living with diabetes mellitus (DM) are at increased risk of mortality and post-operative complications following hip fracture surgery (HFS) than non-diabetics. Studies investigating databases in American, European or Asiatic populations highlight the impact geography can have on the resultant investigation. We aim to quantify the impact DM has on HFS patients in a single university hospital. The HIPE dataset of fragility fractures occurring in Galway University Hospital from 2014–2016 were analysed and cross referenced with hospital laboratory and public databases. A database of 759 individuals was created including 515 females and 237 males, with a mean age of 78+/−12.2 years, of which 110 patients had DM. The patient length-of-stay (PLOS) was comparable in all groups with patient age being the primary influencing factor. An extended PLOS correlated with an increased long-term mortality. A trend toward increased occurrence of sub-trochanteri...
[Current therapy concepts in cutaneous T-cell lymphomas]. (1997)

Cutaneous T-cell-lymphomas (CTCL) include a group of rare diseases that are characterized by an accumulation of clonal T-lymphocytes in skin. The various disease entities may be classified by an adapted Kiel classification. For staging purposes the TNM system is most commonly used. Treatment modalities depend on the extent and the aggressiveness of the disease (low- or high-grade lymphoma) and on the individual situation of the patient. Stage-adapted therapy is currently recommended. Early stages of low-grade CTCL are successfully treated with PUVA, retinoids or interferon-alpha. Extracorporeal photopheresis is the treatment of choice in stage III patients with Sézary syndrome. Alternative therapeutic modalities for CTCL, such as radiotherapy, chemotherapy or various experimental protocols, are discussed.
The D-100 performance and plume characterization on krypton (1996)

Peer Reviewed
Repeated computation of global functions in a distributed environment (1994)

In a distributed system, many algorithms need repeated computation of a global function. These algorithms generally use a static hierarchy for gathering the necessary data from all processes. As a result, they are unfair to processes at higher levels of the hierarchy, which have to perform more work than processes at lower levels do. In this paper, we present a new revolving hierarchical scheme in which the position of a process in the hierarchy changes with time. This reorganization of the hierarchy is achieved concurrently with its use. It results in algorithms that are not only fair to all processes but also less expensive in terms of messages. The reduction in the number of messages is achieved by reusing messages for more than one computation of the global function. The technique is illustrated for a distributed branch-and-bound problem and for asynchronous computation of fixed points.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Flattening of copper surfaces with a low energy xenon-ion source generated by photoemission-assisted plasma (2019)

Abstract Copper surfaces with an initial root mean square roughness of 2–5 nm were processed by a photoemission-assisted plasma ion source. When exposed to Ar + ion at energy of 26.0 eV and fluence of 3.12 × 10 18 ions cm −2 , roughness increased from 2.27 ± 0.04 to 4.48 ± 2.20 nm with crater formation. In contrast, a significant decrease of roughness from 2.89 ± 0.07 to 1.37 ± 0.08 nm was achieved by irradiating with Xe + ions at 26.5 eV and 3.12 × 10 18 ions cm −2 . The whole surface of a 3 inch Cu/Si wafer was successfully flattened by irradiation with 26.5 eV Xe + ions from 4.14 ± 0.16 to 1.95 ± 0.17 nm.
Sparse Expansions of Multicomponent Oxide Configuration Energy Using Coherency & Redundancy (2021)

Compressed sensing has become a widely accepted paradigm to construct high dimensional cluster expansion models used for statistical mechanical studies of atomic configuration in complex multicomponent crystalline materials. However, strict sampling requirements necessary to obtain minimal coherence measurements for compressed sensing to guarantee accurate estimation of model parameters are difficult and in some cases impossible to satisfy due to the inability of physical systems to access certain configurations. Nevertheless, the dependence of energy on atomic configuration can still be adequately learned without these strict requirements by using compressed sensing by way of coherent measurements using redundant function sets known as frames. We develop a particular frame constructed from the union of all occupancy-based cluster expansion basis sets. We illustrate how using this highly redundant frame yields sparse expansions of the configuration energy of complex oxide materials that are competitive and often surpass the prediction accuracy and sparsity of models obtained from standard cluster expansions.
MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner (2020)

Our findings establish a novel role for MCT4 as a critical regulator of cellular deoxyribonucleotide levels and provide a new therapeutic direction related to MCT4 depletion in GBM.
Neurogenic Dural Protein Extravasation Induced by Meta-Chlorophenylpiperazine (Mcpp) Involves Nitric Oxide and 5-HT2B Receptor Activation (2003)

The compound m-chlorophenylpiperazine (mCPP), which is known to trigger migraine-like head pain in some subjects, was evaluated for its ability to induce dural plasma protein extravasation (PPE) in guinea pigs. Intravenous mCPP dose-dependently increased PPE. This effect was inhibited by non-selective 5-HT2 receptor antagonists (methysergide, LY53857, LY215840), by a peripherally restricted 5-HT2 receptor antagonist (xylamidine) and by a 5-HT2B selective receptor antagonist (LY202146). These data suggests that peripheral 5-HT2B receptors mediate mCPP-induced PPE. The nitric oxide synthase inhibitor L-NAME and 5-HT1 agonist sumatriptan also blocked mCPP-induced PPE, suggesting a role for nitric oxide (NO) and the trigeminal system, respectively. NO release has been linked to activation of the 5-HT2B receptor on the vascular endothelium. However, LY202146 did not block PPE induced by electrical stimulation of the trigeminal ganglion. These data are consistent with activation of peripheral 5-HT2B receptors initiating PPE and the theory that selective 5-HT2B antagonists might be effective prophylactic therapies for migraine.
Hypoxia selectively induces proliferation in a specific subpopulation of smooth muscle cells in the bovine neonatal pulmonary arterial media. (1995)

Medial thickening of the pulmonary arterial wall, secondary to smooth muscle cell (SMC) hyperplasia, is commonly observed in neonatal hypoxic pulmonary hypertension. Because recent studies have demonstrated the existence of multiple phenotypically distinct SMC populations within the arterial media, we hypothesized that these SMC subpopulations would differ in their proliferative responses to hypoxic pulmonary hypertension and thus contribute in selective ways to the vascular remodeling process. Expression of meta-vinculin, a muscle-specific cytoskeletal protein, has been shown to reliably distinguish two unique SMC subpopulations within the bovine pulmonary arterial media. Therefore, to assess the proliferative responses of phenotypically distinct SMC subpopulations in the setting of neonatal pulmonary hypertension, we performed double immunofluorescence staining on pulmonary artery cryosections from control and hypertensive calves with antibodies against meta-vinculin and the proliferation-associated nuclear antigen, Ki-67. We found that, although neonatal pulmonary hypertension caused significant increases in overall cell replication, proliferation occurred almost exclusively in one, the meta-vinculin-negative SMC population, but not the other SMC population expressing meta-vinculin. We also examined fetal pulmonary arteries, where proliferative rates were high and meta-vinculin expression again reliably distinguished two SMC subpopulations. In contrast to the hypertensive neonate, we found in the fetus that the relative proliferative rates of both SMC subpopulations were equal, thus suggesting the existence of different mechanisms controlling proliferation and expression of cytoskeletal proteins in the fetus and neonate. We conclude that phenotypically distinct SMC populations in the bovine arterial media exhibit specific and selective proliferative responses to neonatal pulmonary hypertension. Distinct SMC subpopulations may, thus, contribute in unique ways to vascular homeostasis under both normal and pathologic conditions.
La colaboración de José Bergamín en las revistas literarias entre 1921 y 1939 (1992)

ESTUDIO QUE PERMITE AHONDAR EN EL CONOCIMIENTO DE LA ETAPA LITERARIA DESDE 1921 A 1939 A TRAVES DEL CAMPO ESPECIFICO DE LAS REVISTAS LITERARIAS Y, EN PARTICULAR, POR LA COLABORACION EN ALGUNAS DE ELLAS DE UNO DE LOS MIEMBROS MAS ORIGINALES Y POLEMICOS DE LA GENERACION DEL 27, JOSE BERGAMIN. EL PENSAMIENTO DE BERGAMIN SE NOS VA DESVELANDO, PRIMERO, AL ANALIZAR LA HISTORIA DE LAS REVISTAS EN QUE COLABORO, POR EJEMPLO, SU POLEMICA CON ORTEGA Y GASSET, SU PERCEPCION CRITICA RESPECTO AL 98, ETC (PRIMERA PARTE DE LA TESIS); Y LUEGO, A PARTIR DEL ANALISIS DE LOS GENEROS LITERARIOS A LOS QUE PASA REVISTA Y A LAS IDEAS QUE LE IMPRESIONARON DURANTE ESTA EPOCA (SEGUNDA PARTE DE LA TESIS). EL INTERES DE SU PENSAMIENTO (VERTIDO EN DECENAS DE PUBLICACIONES LITERARIAS Y COMENTADO EN MUCHAS OTRAS) PERMITE COMPRENDER MEJOR NO SOLO UNA PAGINA DE NUESTRA HISTORIA LITERARIA, SINO SU PROPIA VISION DE LA LITERATURA UNIVERSAL CLASICA, SOBRE TODO EN EL TERRENO POETICO Y EN EL FILOSOFICO, AL OFRECERNOS UN COMPENDIO NADA DESDENABLE DE TEXTOS DE AUTORES CLASICOS Y MODERNOS, POR EL CRITICADOS. LA TESIS OFRECE TABLAS DE ORIGINALES, CITAS Y REVISTAS UTILIZADAS EN LA INVESTIGACION.
Immunopurification and Analysis of Protein and RNA Components of mRNP in Mammalian Cells (2004)

We describe a basic, fast, and reliable technique to isolate and characterize ribonucleoprotein (RNP) using antibody to a constituent protein. The antibody serves to immunopurify RNP from total cells or nuclear and cytoplasmic cell fractions under conditions that promote RNP integrity. The presence of other RNP proteins as well as transcripts can then be analyzed by Western blotting and reverse transcription polymerase chain reaction, respectively. RNase treatment before immunopurification can be used to assess the dependence of protein-protein interactions on RNA. We also describe a modification using beta-mercaptoethanol that facilitates analyzing proteins that comigrate with antibody light or heavy chains.
Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States (2020)

We analyzed the cost-effectiveness of treating incident chronic myeloid leukemia in chronic phase (CML-CP) with generic imatinib when it becomes available in United States in 2016. In the year following generic entry, imatinib’s price is expected to drop 70% to 90%. We hypothesized that initiating treatment with generic imatinib in these patients and then switching to the other tyrosine-kinase inhibitors (TKIs), dasatinib or nilotinib, because of intolerance or lack of effectiveness (“imatinib-first”) would be cost-effective compared with the current standard of care: “physicians’ choice” of initiating treatment with any one of the three TKIs.
Noise Levels During College Football Games and Associated Effects on Players and Fans (2008)

Crowd noise levels in large stadiums are often discussed in the press and by the casual stadium patron; however, there has been little scientific evaluation of these levels and their corresponding effects. An effort was undertaken at Penn State University to measure noise on the field at Beaver Stadium (State College, PA: capacity 107,282) during a PSU football game. The two-fold purpose of these measurements was to evaluate the noise levels with respect to how they affect the game and make real-time, calibrated recordings for future use in the football team’s indoor practice facility. Measurements were taken on the field level using sound levels meters and DAT recorders throughout the PSU vs. Ohio State University football game on 27 October 2007. As a point of comparison, similar measurements were conducted by a team of researchers from Virginia Tech during the VT vs. University of Miami game on 17 November 2007 at Lane Stadium (Blacksburg, VA: capacity 66,233). The crowd noise levels are compared between the two stadiums taking into account the circumstances of the two games, time of day, and design of the stadiums. The levels on the field are evaluated in terms of speech intelligibility, i.e. the ability of the players to communicate with each other. In addition, a hearing loss safety assessment for both fans and players is presented.
A numerical/experimental investigation of microcontamination in a rotating disk chemical vapor deposition reactor (2001)

Driven by a relentless decrease in feature size, the allowable particle contaminant size during semiconductor fabrication is now less than 100 nm. Particles in this size range (microcontaminants) in chemical vapor deposition (CVD) reactors are primarily gas-phase generated and are poorly understood. The purpose of the investigation described here is to enhance the understanding of the formation, transport and growth of microcontaminants in thermal CVD reactors. The approach being employed is to carry out a combined numerical/experimental study in which the particle dynamics are both modeled and optically probed in a rotating disk CVD reactor. The rotating disk configuration is utilized because of its simple and well-defined flow in which a particle layer forms in a highly accessible region of the reactor just above the substrate. Numerical/experimental comparisons of layer location and shape as a function of disk rotation rate are shown to be excellent if two empirically-determined parameters in the model are properly chosen.
Efficient collision detection using bounding volume hierarchies of k-DOPs (1998)

Collision detection is of paramount importance for many applications in computer graphics and visualization. Typically, the input to a collision detection algorithm is a large number of geometric objects comprising an environment, together with a set of objects moving within the environment. In addition to determining accurately the contacts that occur between pairs of objects, one needs also to do so at real-time rates. Applications such as haptic force feedback can require over 1000 collision queries per second. We develop and analyze a method, based on bounding-volume hierarchies, for efficient collision detection for objects moving within highly complex environments. Our choice of bounding volume is to use a discrete orientation polytope (k-DOP), a convex polytope whose facets are determined by halfspaces whose outward normals come from a small fixed set of k orientations. We compare a variety of methods for constructing hierarchies (BV-trees) of bounding k-DOPs. Further, we propose algorithms for maintaining an effective BV-tree of k-DOPs for moving objects, as they rotate, and for performing fast collision detection using BV-trees of the moving objects and of the environment. Our algorithms have been implemented and tested. We provide experimental evidence showing that our approach yields substantially faster collision detection than previous methods.
Large Scale Screening and Quantitative Analysis of Site-Specific N-Glycopeptides from Human Serum in Early Alzheimer's Disease Using LC-HCD-PRM-MS. (2022)

Glycopeptide analysis by mass spectrometry may provide an important opportunity in discovery of biomarkers to aid in early detection of Alzheimer's Disease (AD). In this work, we have used a NanoLC-Stepped-HCD-DDA-MS/MS platform and a NanoLC-Stepped-HCD-PRM-MS platform for large-scale screening and quantification of novel N-glycopeptide biomarkers for early detection of AD in patient serum. N-glycopeptides were retrieved from 10 μL of serum in patients with mild cognitive impairment (MCI, a prodromal phase of AD) and normal controls, respectively, after trypsin digestion, glycopeptide enrichment, fractionation, and NanoLC-Stepped-HCD-DDA-MS/MS or NanoLC-Stepped-HCD-PRM-MS analysis. Using a combination of Byonic, Byologic and Skyline softwares, we were able to accomplish both identification and label-free quantitation of site-specific N-glycopeptides between MCI and normal controls. Differential quantitation analysis by Byologic showed that 29 N-glycopeptides derived from 16 glycoproteins were significantly changed in MCI compared to normal controls. Further, HCD-PRM-MS quantitative analysis of the selected N-glycopeptide candidates confirmed that EHEGAIYPDN138TTDFQR_HexNAc(4)Hex(5)-Fuc(2)NeuAc(1) from CERU, and VCQDCPLLAPLN156DTR_HexNAc(4)Hex(5)NeuAc(2) from AHSG can significantly discriminate MCI from normal controls. These two glycopeptides had the area under the receiver operating characteristic curve (AUC) of 0.850 (95% CI, 0.66-1.0) and 0.867 (95% CI, 0.68-1.0), respectively (p<0.05). The result demonstrates that changes in the expression level of the N-glycopeptides provide potential serum biomarkers for detection of AD at a very early stage.
ChemInform Abstract: Synthesis of 2′‐(tert‐Butyloxycarbonyl)ribonucleosides. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stereoselective homogeneous hydrogenation of arenes to cyclohexanes catalysed by [Rh(η5-C5Me5)Cl2]2 (1977)

[Rh(η5-C5Me5)Cl2]2 catalyses the hydrogenation of benzene and a variety of substituted benzenes to the appropriate cyclohexanes under homogeneous conditions (50 °C, 50 atm) in the presence of base (Et3N); the reaction is highly stereoselective and all-cis isomers are the chief products.
Electrical remodeling of the epicardial border zone in the canine infarcted heart: a computational analysis (2003)

The density and kinetics of several ionic currents of cells isolated from the epicardial border zone of the infarcted heart (IZs) are markedly different from cells from the noninfarcted canine epicardium (NZs). To understand how these changes in channel function affect the action potential of the IZ cell as well as its response to antiarrhythmic agents, we developed a new ionic model of the action potential of a cell that survives in the infarct (IZ) and one of a normal epicardial cell (NZ) using formulations based on experimental measurements. The difference in action potential duration (APD) between NZ and IZ cells during steady-state stimulation (basic cycle length = 250 ms) was 6 ms (156 ms in NZ and 162 ms in IZ). However, because IZs exhibit postrepolarization refractoriness, the difference in the effective refractory period (ERP), calculated using a propagation model of a single fiber of 100 cells, was 43 ms (156 ms in NZ and 199 ms in IZ). Either an increase in L-type Ca(2+) current (to simulate the effects of BAY Y5959) or a decrease of both or either delayed rectifier currents (e.g., to simulate the effects of azimilide, sotalol, and chromanol) had significant effects on NZ ERP. In contrast, the effects of these agents in IZs were minor, in agreement with measurements in the in situ canine infarcted heart. Therefore 1) because IZs exhibit postrepolarization refractoriness, conclusions drawn from APD measurements cannot be extrapolated directly to ERPs; 2) ionic currents that are the major determinants of APD and the ERP in NZs are less important in IZs; and 3) differential effects of either BAY Y5959 or azimilide in NZs versus IZs are predicted to decrease ERP dispersion and in so doing prevent initiation of arrhythmias in a substrate of inhomogeneous APD/ERPs.