gebhart/patrepeval huggingface dataset:
A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer (2019)

Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC in recent years, additional novel targeted agents are needed to improve the efficiency and to offer more options for patients. Antibody-drug conjugates (ADCs) utilize a chemical linker to conjugate cytotoxic drugs to a monoclonal antibody to maximize the delivery to target cells and minimize the delivery to other normal cells. The aim of this study was to prepare a novel anti-CD147 conjugate and examine the tumoricidal effect on NSCLC in vitro and in vivo. HcHAb18 was conjugated to the drug maytansinoid 1 (DM1) via a non-cleavable thioether linker (SMCC) to prepare HcHAb18-DM1 with an appropriate drug-antibody ratio (DAR). NSCLC cell lines expressing different levels of CD147 were tested in vitro to determine internalization, cell cycle arrest and cytotoxicity. In vivo efficacy and safety of HcHAb18-DM1 were evaluated in NSCLC xenograft mouse models. We found that HcHAb18-DM1 displayed an impressive potency in vitro and in vivo with a favorable safety profile. Upon binding to CD147, HcHAb18 could be internalized and delivered the payload DM1 to disturb mitotic spindle formation by microtubules. Target cells were arrested at G2/M phase and HcHAb18-DM1 exerted antiproliferative activity in vitro. Antigen-antibody binding and target cells with high growth rate were two integral prerequisites for exerting anti-tumor activity of HcHAb18-DM1. Therefore, we suggest HcHAb18-DM1 is a promising CD147-targeted therapeutic for NSCLC.
A comparison between the effects of trans membrane and secretory tumor necrosis factor-alpha on tumor necrosis factor receptors (1998)

It is still a matter in dispute whether the bioactivity of membrane-associated form of tumor necrosis factor-alpha(mTNF-alpha) is TNF receptor (TNFR)-dependent. In the present study, it has been shown that preincubation of both forms of TNF with soluble TNFR markedly inhibited their cytotoxic effect on target cells. Blocking of target cell TNFRs by sTNF depressed the cytotoxicity of sTNF on these cells, but has no influence on the effect of mTNF on the same target cells. In comparing the cytotoxic effects of the two forms of TNF on cell lines expressing different TNFR types, we niticed that cells primarily expressing TNFR I were sensitive to sTNF, while those expressing TNFR I and/or TNFR II could be killed by mTNF. As was mTNF, antibodies against TNFR were also cytotoxic to tumor cell lines resistant to sTNF. The cytotoxicity of mTNF was not influenced by preincubation its target cells with anti-TNFR McAbs suggesting a difference in TNFR-binding sites and a possible similarity in the transcellular signal transduction between these two substances.
Velocity-specific atomic-state selection in an atomic beam by continuous-wave optical pumping (1983)

We present experimental results demonstrating strong velocity-distribution modification in a specific atomic state using optical pumping between hyperfine split levels. These results show that the velocity of a specific state can be defined within 6%, corresponding to a local temperature of 1 K. The velocity-specific-state selection is accomplished by using a nearly effusive atomic beam of sodium and a single frequency-stabilized dye laser.
HYDROPHOBIC-HYDROPHILIC SEPARATION (HHS) PROCESS FOR THE RECOVERY AND DEWATERING OF ULTRAFINE COAL (2016)

Flotation is regarded as the best available method of upgrading minerals and coal fines. However, its efficiency deteriorates rapidly with decreasing particle size. Further, ultrafine concentrates are difficult to be dewatered economically, forcing companies to discard part of the ultrafine materials to impoundments. To overcome these problems, a new method of separating and simultaneously dewatering ultrafine particles has been developed. Following extensive laboratory-scale test work, the process, known as hydrophobichydrophilic separation (HHS), has been tested successfully in continuous operations at proof-ofconcept (POC)- and pilot-scale tests. The results show that the HHS process is capable of producing high quality clean coal with high recoveries and low moistures.
The Core Protein of the Chondroitin Sulfate Proteoglycan Phosphacan Is a High-affinity Ligand of Fibroblast Growth Factor-2 and Potentiates Its Mitogenic Activity (1998)

Using a radioligand binding assay we have demonstrated that phosphacan, a chondroitin sulfate proteoglycan of nervous tissue that also represents the extracellular domain of a receptor-type protein tyrosine phosphatase, shows saturable, reversible, high-affinity binding (Kd approximately 6 nM) to fibroblast growth factor-2 (FGF-2). Binding was reduced by only approximately 35% following chondroitinase treatment of the proteoglycan, indicating that the interaction is mediated primarily through the core protein rather than the glycosaminoglycan chains. Immunocytochemical studies also showed an overlapping localization of FGF-2 and phosphacan in the developing central nervous system. At concentrations of 10 microg protein/ml, both native phosphacan and the core protein obtained by chondroitinase treatment potentiated the mitogenic effect of FGF-2 (5 ng/ml) on NIH/3T3 cells by 75-90%, which is nearly the same potentiation as that produced by heparin at an equivalent concentration. Although studies on the role of proteoglycans in mediating the binding and mitogenic effects of FGF-2 have previously focused on cell surface heparan sulfate, our results indicate that the core protein of a chondroitin sulfate proteoglycan may also regulate the access of FGF-2 to cell surface signaling receptors in nervous tissue.
Impact of L-ornithine L-aspartate on non-alcoholic steatohepatitis-associated hyperammonemia and muscle alterations (2022)

Our study confirms the perturbation of hepatic ammonia detoxification pathways in NASH. Results from the interventional experiments suggest a direct beneficial impact of LOLA on skeletal muscle during NASH development, though it does not improve ammonia metabolism or liver disease.
Feasibility and Clinical Outcome of Reboa in Patients with Impending Traumatic Cardiac Arrest (2019)

Our study has shown that REBOA may be performed in patients with ITCA, SBP can be elevated, and 36.6% of the patients survived if REBOA placement is successful.
A sensitive EUV Schwarzschild microscope for plasma studies with sub-micrometer resolution (2018)

We present an extreme ultraviolet (EUV) microscope using a Schwarzschild objective which is optimized for single-shot sub-micrometer imaging of laser-plasma targets. The microscope has been designed and constructed for imaging the scattering from an EUV-heated solid-density hydrogen jet. Imaging of a cryogenic hydrogen target was demonstrated using single pulses of the free-electron laser in Hamburg (FLASH) free-electron laser at a wavelength of 13.5 nm. In a single exposure, we observe a hydrogen jet with ice fragments with a spatial resolution in the sub-micrometer range. In situ EUV imaging is expected to enable novel experimental capabilities for warm dense matter studies of micrometer-sized samples in laser-plasma experiments.
Hindered Rotation in Arylnaphthalene Lignans (1996)

Many arylnaphthalene lignans show biological activity and although few of them contain stereogenic centers, they may nevertheless be chiral if there is hindered rotation about the aryl−naphthalene bond. A relatively high barrier to rotation may give rise to separable rotational enantiomers (atropisomers) which might have quite different pharmacological properties. In order to investigate this possibility we have synthesized the natural products justicidin A, justicidin B, retro-helioxanthin, retro-justicidin B, and helioxanthin as well as four other arylnaphthalenes lignan analogs. We have studied the aryl−naphthalene rotational barrier in these compounds by dynamic NMR and HPLC and find barriers to rotation ranging from 16.9 to 21.5 kcal/mol. This translates to half-lives for individual atropisomers of less than 10 min at room temperature. The experimentally found barriers are compared to those obtained from molecular orbital calculations.
A Theory of Fermat Paths for Non-Line-Of-Sight Shape Reconstruction (2019)

We present a novel theory of Fermat paths of light between a known visible scene and an unknown object not in the line of sight of a transient camera. These light paths either obey specular reflection or are reflected by the object's boundary, and hence encode the shape of the hidden object. We prove that Fermat paths correspond to discontinuities in the transient measurements. We then derive a novel constraint that relates the spatial derivatives of the path lengths at these discontinuities to the surface normal. Based on this theory, we present an algorithm, called Fermat Flow, to estimate the shape of the non-line-of-sight object. Our method allows, for the first time, accurate shape recovery of complex objects, ranging from diffuse to specular, that are hidden around the corner as well as hidden behind a diffuser. Finally, our approach is agnostic to the particular technology used for transient imaging. As such, we demonstrate mm-scale shape recovery from pico-second scale transients using a SPAD and ultrafast laser, as well as micron-scale reconstruction from femto-second scale transients using interferometry. We believe our work is a significant advance over the state-of-the-art in non-line-of-sight imaging.
Sherardia arvensis L. (2006)

https://thekeep.eiu.edu/herbarium_specimens_byname/4772/thumbnail.jpg
The evolution into and the treatment of late stage polycythemia vera. (1976)

The onset of postpolycythemic myeoloid metaplasia or spent polycythemia has been recognized for many years. As the result of many different series, the development of postpolycythemic myeolid metaplasia might be expected in from 15%-20% of patients with postpolycythemia vera. It appears that an etiologic role for sodium phosphate 32P may exist in this evolutionary pattern. About 70% of patients with PPMM will have symptoms with the onset of the syndrome. The major mechanisms producing symptoms result from (1) anemia, (2) pressure from massive splenomegaly, and (3) bleeding problems. Iron deficiency is a frequent cause of anemia in patients with PPMM. The major mechanism of anemia in these patients, however, relates to ineffective erythropoiesis and shortened red cell survival. Androgen trials for ineffective erythropoiesis seem worthwhile, although data on this point is too limited to draw any firm conclusions. A steroid trial for those patients with major hemolytic episodes is indicated. In those patients in whom adrenal steroid therapy fails to control major hemolysis, a consideration for splenectomy exists. Pressure-related manifestations secondary to massive splenomegaly have been treated with radiation therapy and oral alkylators. Although there is data to document amelioration of painful symptoms with associated shrinking of the spleen, long-term control of this problem has not been forthcoming. Again, patients who are medical failures in control of pressure-related manifestations may be considered for splenectomy. Bleeding problems may arise with PPMM secondary to thrombocytopenia, thrombocythemia, or qualitative platelet dysfunction. Adrenal steroids have met with some success in improving platelet counts in patients with life-threatening thrombocytopenia. Those patients who are medical failures with adrenal steroids in terms of thrombocytopenia might be candidates for splenectomy. Control of thrombocythemia has been observed with oral alkylator therapy and chlorambucil may have a special role in managing this complication. Qualitative platelet defects leading to severe bleeding are best managed with fresh platelet transfusions. Patients with PPMM in contrast to patients with agnogenic myeoloid metaplasia have a more lethal syndrome and shortened survivorship. Causes of death in patients with PPMM include cardiac problems, transition to acute leukemia, hemorrhage, and infection.
Reactions of Aromatic Carboxylates. I. Evidence for the Intermediacy of Benzyne in the Pyrolyses of o-Halobenzoates1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Aromatic Carboxylates. I. Evidence for the Intermediacy of Benzyne in the Pyrolyses of o-Halobenzoates1Edward McNelisCite this: J. Org. Chem. 1963, 28, 11, 3188–3194Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/jo01046a057https://doi.org/10.1021/jo01046a057research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modification of lignin composition an content in poplar via genetic engineering (1997)

*INRA, Centre de Versailles Diffusion du document : INRA, Centre de Versailles
High‐frequency subbottom reflection types and lithologic and physical properties of sediments (1982)

Abstract Eight types of reflections are interpreted from 3,800 km of 3.5 kHz profiles taken over a 25,000 km2 area of the upper continental slope and shelf in the northeastern Gulf of Mexico off Panama City, Florida. The corresponding sediments in five of the reflection types were sampled in 77 piston cores from which data were obtained on in situ acoustic velocities (V), bulk densities (gr), sediment texture (mean grain size = Mz), CaCO3 content (C), sedimentary structures, and gross sediment composition. A distinct bottom echo with numerous subbottom reflectors (Type I) is observed in deeper areas where terrigenous clay or lutite (Mgi = 9.9 to, gr = 1.4 g/cc, porosity (P) = 74 percent, C = 28 percent, and V (upper 2 m) = 1,435 m/s) predominates. Type I reflection grades upslope into Type IV, which shows a distinct bottom echo with fewer subbottom reflectors, and the corresponding sediment is a foraminiferal silty clay (mz = 9.4 to, gr = 1.43 g/cc, P = 73 percent, V = 1,447 m/s, and C = 37 percent). The uppermost slope gives indistinct, semiprolonged bottom echoes with faint subbottoms (Type VI) where calcareous silt (Mz = 6.6 to, gr = 1.57 g/cc, P = 65 percent, C = 70 percent, and V = 1,482 m/s) is the main sediment type. The shelf sediments (gr = 1.66 g/cc, P = 58 percent, V = sl1,530 m/ s), varying from coarse silt (Mz = 5.3 to) to very coarse sand (Mz = ‐0.3 to) and 25 to 100 percent carbonate, show indistinct, semiprolonged bottom echoes with intermittent or mushy subbottoms (Type VII). Prolonged echoes with no subbottoms (Type VIII) are observed in areas where algal sands of variable grain size (Mz ‐ ‐0.9 to 2.7 to, gr = 1.66 g/cc, P = 59 percent, V = 1,530 to 1,690 m/s) occur. The major trends in reflection types (loss in depth of penetration, loss in number of reflectors, and prolongation of initial bottom reflections) follow gradients of sedimentary and physical properties of the sediments, which are increases in mean grain size, bulk density, in situ acoustic velocity, CaCO3 content, and decrease in porosity. Increases in the reflection coefficient and attenuation of the sound energy in the shelf sediments are probably important factors in the observed decrease in the depth of penetration of the sound energy in the shelf sediments.
I n s i t u chemical etching of GaAs(001) and InP(001) substrates by gaseous HCl prior to molecular-beam epitaxy growth (1987)

I n situ chemical etching of GaAs (001) and InP (001) by gaseous HCl before molecular-beam epitaxy (MBE) growth, on substrates previously etched with H2SO4/H2O2/H2O, has been studied by different surface and interface analysis techniques. Oxide free GaAs surfaces are obtained for low HCl pressures (p≥0.1 Torr) at 25 °C. The residual adsorbed chlorine is removed at 450 °C under vacuum or As4 pressure. In contrast to what is observed for GaAs, the surface oxide layer of InP substrates is not eliminated by gaseous HCl at room temperature. Capacitance–voltage measurements recorded after MBE growth on HCl gas deoxidized GaAs substrates do not detect any electrical perturbation of the substrate/layer interface, although the ion microprobe profiles show an increase in carboneous contamination of this interface. Moreover, the growth defect density is around four times lower when a deoxidation step by HCl gas is performed before the epitaxial growth of GaAs layers.
Suggesting Topic-Based Query Terms as You Type (2010)

Query term suggestion that interactively expands the queries is an indispensable technique to help users formulate high-quality queries and has attracted much attention in the community of web search. Existing methods usually suggest terms based on statistics in documents as well as query logs and external dictionaries, and they neglect the fact that the topic information is very crucial because it helps retrieve topically relevant documents. To give users gratification, we propose a novel term suggestion method: as the user types in queries letter by letter, we suggest the terms that are topically coherent with the query and could retrieve relevant documents instantly. For effectively suggesting highly relevant terms, we propose a generative model by incorporating the topical coherence of terms. The model learns the topics from the underlying documents based on Latent Dirichlet Allocation (LDA). For achieving the goal of instant query suggestion, we use a trie structure to index and access terms. We devise an efficient top-k algorithm to suggest terms as users type in queries. Experimental results show that our approach not only improves the effectiveness of term suggestion, but also achieves better efficiency and scalability.
Assessment of Pressure Drop Flowrate Relationship of Axillobifemoral Bypass Grafts (1991)

An in vitro study was conducted to measure the pressure distributions in knitted polyester axillobifemoral bypass grafts under steady and pulsatile flow of a Newtonian fluid. The relationship between pressure drop and flowrate was determined across the outflow branches of two types of axillobifemoral grafts. Pressure losses were greater across the 90 degrees side branch of the T-type graft than in the Y-type graft at all Reynolds numbers studied. Mean pulsatile pressure drops in the T graft were greater than those measured in steady flow at the same Reynolds number. Estimates of the likely in vivo pressure drops are made under resting and exercise flow conditions. It is suggested that the Y graft is less likely to have a significant effect on blood supply to the lower limbs, even at high blood flowrates.
Emerging role of RUNX3 in the regulation of tumor microenvironment (2018)

A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy. [BMB Reports 2018; 51(4): 174-181].
Co-ordinative ellipsis in Russian texts (1988)

Russian elliptic constructions are examined from the point of view of syntactic analysis. Reciprocal elements in a co-ordinative elliptic sentence are exposed and possible types of their similarity are explored. Linear formulae of ellipsis for most textual cases are constructed and statistics of their use is discussed. As a result the main steps of ellipsis restoration algorithm are outlined.
XXII (2010)

<sc>He</sc> had slightly misrepresented the matter in saying that Catherine had consented to take the great step. We left her just now declaring that she would burn her ships behind her; but Morris, after having elicited this declaration, had become conscious of good reasons...
The outsider in the plays of John Osborne (1973)

Colin Wilson described the Outsider as one who sees life as it really is and who does something about those aspects of society he believes need changing. John Osborne is an Outsider who attacks society through his plays. His spokesman may be a character who is a true Outsider, or he may be only a partial Outsider. At other times Osborne's perspective emerges mainly through situation rather than character.
Cepstral Features For Classification Of An Impulse Response With Varying Sample Size Dataset (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007