gebhart/patrepeval huggingface dataset:
Characterization and functional studies of rheumatoid synovial mast cells: Activation by secretagogues, anti‐IgE, and a histamine‐releasing lymphokine (1986)

Microscopic analysis of synovial specimens from 35 patients with rheumatoid arthritis (RA) and 7 patients with osteoarthritis revealed mast cell hyperplasia in perivascular regions, in fibrous interstitial areas, and clustered around the periphery of lymphoid aggregates. Metachromatic staining, immunofluorescence studies, and ultrastructural analysis revealed a single population of connective tissue-type mast cells with surface IgE receptors. Total extractable histamine of synovial tissue was 4.15 +/- 2.30 micrograms/gm (n = 8) for RA synovium and 0.53 +/- 0.23 microgram/gm (n = 7) for OA synovium. Mast cell secretion was assessed and specific release of histamine from RA synovial mast cells was observed following stimulation with anti-IgE (32.3%), compound 48/80 (40.1%), calcium ionophore A23187 (25.2%), and a partially purified lymphokine with histamine-releasing activity (23.9%).
Well-Being of Family Caregivers of Persons with Late-Stage Huntington's Disease: Lessons in Stress and Coping (2009)

The utility of a stress-process model in predicting health and quality-of-life outcomes for family caregivers of persons with Huntington's disease (HD) was tested. HD is an inherited neurodegenerative disease that poses particular challenges to patients and families. Seventeen family caregivers were interviewed and completed scales measuring stressors, appraisals, protective factors, and outcomes. No direct relationship between stress and caregiver well-being was found; the impact of stressors was mediated by appraisals and protective factors. Bivariate correlation analysis revealed significant positive relationships between satisfaction with emotionally supportive communication and life satisfaction. Significant positive correlations were found between positive appraisals of the benefits of the caregiving experience and life satisfaction and health. Mastery was significantly positively correlated with life satisfaction and negatively correlated with depressive symptoms; similar results were found between spirituality and outcome measures. Caregivers' interpretations appeared to have a more significant impact on well-being than did objective characteristics of the experience.
Introduction (2014)

Current dominant thinking and practice in both the private and public sectors continually assert that people's development needs are in conflict with, or mutually exclusive to, the need to conserve the biosphere on which we depend. As a consequence, we are asked to either diminish development in the name of conservation or diminish conservation in the name of development. The efforts to identify complementary objectives, or mutually acceptable trade-offs and compromises, described in this publication indicate, however, that this does not always need to be the case. State of the Apes: Extractive Industries and Ape Conservation, the first in a series, draws attention to the evolving context within which great ape and gibbon habitats are increasingly interfacing with extractive industries.
Neuro-fuzzy application for concrete strength prediction using combined non-destructive tests (2009)

The application of the neuro-fuzzy inference system to predict the compressive strength of concrete is presented in this study. The adaptive neuro-fuzzy inference system (ANFIS) is introduced for training and testing the data sets consisting of various parameters. To investigate the influence of various parameters which affect the compressive strength, 1551 data pairs are collected from the technical literature. These data sets cover early and late compressive strengths from 3 to 365 days and low and high strength in the range 6·3–107·7 MPa. To reflect the effects of other uncertain parameters and in situ conditions, the results of non-destructive tests (NDTs) such as ultrasonic pulse velocity (UPV) and rebound hammer test are also included as input parameters, in addition to mix proportion and curing histories. For the testing of trained ANFIS models, 20 cube specimens and 210 cylinders are prepared, and compressive test and NDTs are conducted. For the comparative study of the applicability of ANFIS models combined with NDT results, four ANFIS models are developed. Depending on whether the input parameters of ANFIS models include NDT results or not, these are distinguished from each other. Among the four models, the ‘ANFIS-UR' model having the parameters for both UPV and rebound hammer test results shows the best accuracy in the prediction of compressive strength.
Manipulation of Single Atoms by Atomic Force Microscopy as a Resonance Effect (2009)

Extraction and deposition of single atoms using an atomic force microscope tip is a promising technique for building nanostructures. Previous theoretical models for this technique, based on adiabatic atom motion in either classical or quantum mechanics settings, encountered an apparent difficulty in explaining atom extraction and deposition for the same experimental conditions. We resolve that difficulty by showing that both extraction and deposition of atoms can be formulated in terms of pure classical mechanics as a resonance effect, arising from a combination of interatomic forces and vibrations of individual atoms.
Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples (2020)

Our in vitro results demonstrate the potential of cannabinoids in developing efficient and safer mouthwash products and next generation oral care products without fluoride and alcohol.
Functional nanocellulose films as fluorescent media (2018)

Fluorescent nanocellulose films fabricated via 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation of cellulose nanofibers were prepared using two methods. In the first process, fluorescent particles were added halfway through the last vacuum filtration step of film fabrication. Three different particles were used: micro-pSi, micro-pSi with COOH, and Si-COOH nanocrystals. Several optical techniques were employed to characterize resulting films: UV-Vis spectrophotometry, fluorescence spectrophotometry, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) microscopy. All techniques revealed that particles retained their intrinsic properties after deposition on the film. Photoluminescence spectra of resulting films at &lambda;<sub>excitation</sub> = 350 nm exhibited the following fluorescence peaks: &lambda;<sub>micro-pSi</sub> = 600 nm, &lambda;<sub>micro-pSi</sub> <sub>with COOH</sub> = 596 nm, &lambda;<sub>Si-COOH nanocrystals</sub> = 618 nm. A blue shift of at most 20 nm was observed when comparing particle fluorescence peak emission before and after deposition on the film. The peak shift was attributed to oxidation, as the particles remained in an aqueous solution during film fabrication. Continued observation of film fluorescence spectra showed that peak emission values are maintained for a month. A second method of fluorescent film fabrication involved the immersion of a dry, transparent nanocellulose film in a chlorophyll in acetone solution. Fluorescence spectra of the resulting hybrid film were taken using a UV laser as the excitation source (&lambda;<sub>excitation</sub> = 355 nm). The fluorescence peak was found to be &lambda;<sub>chlorophyll</sub> = 683.21 nm. Both methods of film hybridization were effective in preparing nanocellulose films that show promise as stable fluorescent media.
Transmitted amplitude by a Fabry-Perot interferometer with random surface defects (1985)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. Martinez-Herrero, P. M. Mejias, and E. Bernabeu, "Transmitted amplitude by a Fabry-Perot interferometer with random surface defects," Appl. Opt. 24, 315-316 (1985) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A neuropsychiatric perspective on traumatic brain injury (2007)

Traumatic brain injury (TBI) due to closed mechanisms causes strain injuries to axons that increase in number and severity as injury severity increases. Axons that project up from the brain stem are vulnerable, even in milder concussive injuries, and include axons that participate in key monoaminergic pathways. Although called diffuse axonal injury, the supra-tentorial injury component typically shows an anterior preponderance in humans. As the injury forces increase, cerebral contusions may be superimposed on the axonal strain injuries, and these contusions show an anterior preponderance as well. The chronic neuropsychiatric manifestations of TBI reflect this injury distribution. In the cognitive sphere, these manifestations almost always include power function disturbances marked by difficulties with cognitive processing speed, multitasking, and cognitive endurance. These disturbances may then be followed by disturbances in executive function and self-awareness as injury severity increases. In the behavioral sphere, mood disturbances and disorders of behavioral control and regulation are particularly common.
The Johns Hopkins Ciccarone Center's expanded ‘ABC's approach to highlight 2020 updates in cardiovascular disease prevention (2021)

In recent years, improvement in outcomes related to cardiovascular disease is in part due to the prioritization and progress of primary and secondary prevention efforts. The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease expanded 'ABC's approach is used to highlight key findings in Preventive Cardiology from 2020 and further emphasize the importance of cardiovascular prevention. This simplified approach helps clinicians focus on the most relevant and up to date recommendations for optimizing cardiovascular disease risk through accurate risk assessment and appropriate implementation of lifestyle, behavioral and pharmacologic interventions. While 2020 not only provided practice changing updates by way of clinical guidelines and randomized controlled trials on topics related to antithrombotic and lipid lowering therapy, diabetes management and risk assessment, it also provided promising data on how to improve dietary and exercise adherence and manage genetic risk. By providing clinicians with a systematic approach to cardiovascular prevention and key highlights from the prior year, the goal of significantly reducing the burden of cardiovascular disease worldwide can be achieved.
Corrigendum to &quot;The influence of seawater pH on U / Ca ratios in the scleractinian cold-water coral &lt;i&gt;Lophelia pertusa&lt;/i&gt;&quot; published in Biogeosciences, 11, 1863–1871, 2014 (2014)

No abstract available.
Characterization and alkane oxidation activity of a diastereopure seven-coordinate iron(iii) alkylperoxo complex (2007)

Spectroscopic characterization and alkane oxidation studies of a diastereopure seven-coordinate high-spin iron(iii) alkylperoxo complex based on the chiral N,N',N-bis(l-prolinate)pyridine ligand Py(ProMe)(2) () are reported.
Pan-cancer organoid validation of tumor outlier chromosomal amplification events (2021)

SUMMARY Somatic copy number gains are pervasive in many cancer types, yet their roles in oncogenesis are often poorly explored. This lack of understanding is in part due to broad extensions of copy gains across cancer genomes spanning large chromosomal regions, obscuring causal driver loci. Here we employed a multi-tissue pan-organoid modeling approach to validate candidate oncogenic loci identified within pan-cancer TCGA data by the overlap of extreme copy number amplifications with extreme expression dysregulation for each gene. The candidate outlier loci nominated by this integrative computational analysis were functionally validated by infecting cancer type-specific barcoded full length cDNA lentiviral libraries into cognate minimally transformed human and mouse organoids bearing initial oncogenic mutations from esophagus, oral cavity, colon, stomach, pancreas and lung. Presumptive amplification oncogenes were identified by barcode enrichment as a proxy for increased proliferation. Iterative analysis validated DYRK2 at 12q15, encoding a serine-threonine kinase, as an amplified head and neck squamous carcinoma oncogene in p53 -/- oral mucosal organoids. Similarly, FGF3 , amplified at 11q13 in 41% of esophageal squamous carcinomas, was validated in p53 -/- esophageal organoids in vitro and in vivo with pharmacologic inhibition by small molecule and soluble receptor FGFR antagonists. Our studies establish the feasibility of pan-organoid contextual modeling of pan-cancer candidate genomic drivers, enabling oncogene discovery and preclinical therapeutic modeling.
Soft and rigid core latex nanoparticles prepared by RAFT-mediated surfactant-free emulsion polymerization for cellulose modification – a comparative study (2017)

Latex nanoparticles of high and low T g -core block-copolymers were produced and their adsorption to (nano)cellulose surfaces was investigated.
EasyPR &#x2014; An easy usable open-source PR system (2013)

In this paper, we present an open source partial reconfiguration (PR) system which is designed for portability and usability serving as a reference for engineers and students interested in using the advanced reconfiguration capabilities available in Xilinx FPGAs. This includes design aspects such as floorplanning and interfacing PR modules as well as fast reconfiguration and online management. The system features relocatable modules which can even contain reconfigurable modules themselves, hence, implementing hierarchical PR.
Crystallization of proteins under microgravity (1989)

For the crystallization of proteins under microgravity conditions, a Chinese re‐entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity conditions crystal growth can only be expected under those crystallization conditions which also permit crystal growthon earth. A number of space‐grown crystals were larger in size and of a better quality in their ability to diffract X‐rays than the corresponding ground control crystals grown at the Chinese launch site. However, the space‐grown crystals have not reached the X‐ray diffraction quality of the crystals obtained under optimal conditions in the home laboratories.
Gene ontology concept recognition using named concept: understanding the various presentations of the gene functions in biomedical literature (2018)

NCGOCR reduced the arduous work of GO annotation and amended the process of searching for the biomarkers or drug targets, leading to improved biomarker development and greater success in precision medicine.
Plasma protein denaturation with graded heat exposure (2013)

During cardiopulmonary bypass (CPB), perfusion at tepid temperatures (33-35 °C) is recommended to avoid high temperature cerebral hyperthermia during and after the operation. However, the ideal temperature for uncomplicated adult cardiac surgery is an unsettled question. Typically, the heat exchanger maximum temperature is monitored between 40-42 °C to prevent denaturation of plasma proteins, but studies have not been performed to make these conclusions. Therefore, our hypothesis was to determine the temperature in which blood plasma protein degradation occurs after 2 hours of heat exposure. As a result, blood plasma proteins were exposed to heat in the 37-50 °C range for 2 hours. Plasma protein samples were loaded onto an 8-12% gradient gel for SDS-PAGE and low molecular weight plasma protein degradation was detected with graded heat exposure. Protein degradation was first detected between 43-45 °C of heat exposure. This study supports the practice of monitoring the heat exchanger between 40-42 °C to prevent denaturation of plasma proteins.
Ligand-Modulated Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein in Human Breast Cancer Cell Lines (1988)

We have examined the effects of estrogen and progestin agonist and antagonist ligands on regulation of progesterone receptor (PR) protein and mRNA levels in a variety of human breast cancer cell lines. By Northern blot analysis, using human PR cDNA probes, PR mRNA in T47D and MCF-7 cells appears as five species of approximately 11.4, 5.8, 5.3, 3.5, and 2.8 kilobases. PR mRNA species are not detected in the PR protein-negative breast cancer cell lines MDA-MB-231 and LY2. T47D cells contain high levels of PR mRNA and protein (detected by hormone binding assay or Western blot analysis), and the PR protein and mRNA content of T47D cells are reduced to about 10% of the control level within 48 h of treatment with 10 nM promegestone; 17, 21-dimethyl-19-nor-pregna-4,9-diene-3, 20-dione (R5020) or 16 alpha-ethyl-21-hydroxy-19-nor-pregn-4-ene-3,20-dione (ORG2058), both potent progestins. In contrast, treatment of T47D cells with the antiprogestin 17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-(1-propynyl)-estra- 4, 9-dien-3-one) (RU38486) reduces PR protein and mRNA levels only transiently. PR protein and mRNA are virtually undetectable in control MCF-7 cells grown in the absence of estrogens. When estradiol is administered to MCF-7 cells, the PR mRNA and protein levels increase gradually and proportionately (10- or 40-fold, respectively, in 3 days).(ABSTRACT TRUNCATED AT 250 WORDS)
Current views on Zika virus vaccine development (2017)

Zika virus (ZIKV) is a mosquito-borne flavivirus, which was identified in 1947 in the Zika Forest of Uganda. The virus has emerged in the recent years and caused large human outbreaks in the Pacific area (Yap Island in 2007; French Polynesia in 2013 to 2014) and in the Americas (since late 2014). As of 8 June 2017, according to the Pan American Health Organization/World Health Organization, 48 countries in South America, Central America, and Caribbean reported ZIKV outbreaks, with a total of 212,545 confirmed cases of infection and 565,749 suspected cases. In addition, in 2016, Florida and Texas (USA) observed 225 autochthonous cases of ZIKV infection. The incidence was estimated as about 200 cases/100,000 population in countries like Brazil, Colombia, and Venezuela, where large and intense epidemic waves were registered during the first half of 2016. Although ZIKV transmission has significantly decreased in the region during the second half of 2016, most of the countries are still reporting cases of infection. Outsides the Americas, areas of ongoing intense transmission include countries in Asia (Singapore, Thailand, Vietnam, Malaysia, and the Philippines), Africa (Angola), and the South Pacific region (American Samoa).
Analysing the role of virtualisation and visualisation on interdisciplinary knowledge exchange in stem cell research processes (2018)

Abstract Interdisciplinary work is an increasingly frequent and important aspect of scientific research. However, successful knowledge exchange and collaboration between experts is itself a challenging activity with both technical and social components that require consideration. Here, this article analyses the cultural factors involved in interdisciplinary research, specifically in the context of a software programme designed to improve knowledge exchange. The authors undertook an ethnographic study to understand the impact of virtualisation and visualisation on an interdisciplinary research team, working together to develop novel imaging technologies for investigating stem cells. In this discovery-research environment the challenge was to determine the socio-technical effect of an in-house software tool called ProtocolNavigator, which provided a virtual laboratory environment for the team to simulate and map their ‘real-life laboratory’ activities. This display, together with activity icons and a timeline, could be visually analysed and transferred between multi-institutional researchers in a non-narrative approach. The aim of the work reported here is to provide the first detailed analysis of how software of this type is used in practice, and to analyse this through a robust social science-based perspective. Subsequently this study examines the effectiveness of this virtual laboratory environment on enhancing communication and understanding using a theoretical framework drawing upon three insights from the Sociology of Expertise and Experience: (i) interactional and contributory expertise, (ii) knowledge exchange and interpretative flexibility, and (iii) trading zones. The framework was extended by introducing the notion of material, concept and practice trade at these trading zones with a demonstration of how interactive visualisation of interconnected trading routes can empower interdisciplinary work. The addition of Foucault’s classic account of power found evidence of a panoptical effect due to the augmented visibility of each other’s work. In summary, the article offers a theoretical framework together with novel analysis to determine the influence of introducing tools and approaches designed to enhance interdisciplinary working—particularly in the context of knowledge sharing and trust.
Potent and Selective Anti‐HIV Activity of 5‐Chloro‐Substituted Derivatives of 3′‐Azido‐2′,3′‐Dideoxycytidine, 3′‐Fluoro‐2′,3′‐Dideoxycytidine, and 2′,3′‐Didehydro‐2′,3′‐Dideoxycytidine (1990)

status: Published
A Drifting-Games Analysis for Online Learning and Applications to Boosting (2014)

We provide a general mechanism to design online learning algorithms based on a minimax analysis within a drifting-games framework. Different online learning settings (Hedge, multi-armed bandit problems and online convex optimization) are studied by converting into various kinds of drifting games. The original minimax analysis for drifting games is then used and generalized by applying a series of relaxations, starting from choosing a convex surrogate of the 0-1 loss function. With different choices of surrogates, we not only recover existing algorithms, but also propose new algorithms that are totally parameter-free and enjoy other useful properties. Moreover, our drifting-games framework naturally allows us to study high probability bounds without resorting to any concentration results, and also a generalized notion of regret that measures how good the algorithm is compared to all but the top small fraction of candidates. Finally, we translate our new Hedge algorithm into a new adaptive boosting algorithm that is computationally faster as shown in experiments, since it ignores a large number of examples on each round.
ChemInform Abstract: Targeting Bacterial Toxins (2012)

Abstract Review: 236 refs.
Scheduling broadcasts in multihop radio networks (1990)

A comprehensive study of the problem of scheduling broadcast transmissions in a multihop, mobile packet radio network is provided that is based on throughput optimization subject to freedom from interference. It is shown that the problem is NP complete. A centralized algorithm that runs in polynomial time and results in efficient (maximal) schedules is proposed. A distributed algorithm that achieves the same schedules is then proposed. The algorithm results in a maximal broadcasting zone in every slot.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Synthesis, emission, electrochemistry and cation-binding studies of ruthenium(II)–diimine–crown and –terpyridine–crown complexes (1997)

A series of ruthenium(II) complexes with crown-containing ligands of the types [Ru(NN) 2 (L′)] 2+ {NN = 2,2′-bipyridine (bipy), L′ = N-(2-pyridinylmethylene)- 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclononadecin-16- ylamine (dic); NN = 1,10-phenanthroline (phen), L′ = dic} and [Ru(NN)(L′)] 2+ {NN = L′ = N-[4-{4′-(2,2′∶6′,2″- terpyridyl)}benzyl]-1,4,7,10-tetraoxa-13-azacyclopentadecane (L 1 ); NN = 2,2′∶6′,2″- terpyridine (terpy), L′ = L 1 } have been synthesized and their emission, electrochemical and cation-binding properties studied.