gebhart/patrepeval huggingface dataset:
Iterative equalization with adaptive soft feedback (2000)

In this letter, a novel equalization algorithm applying soft-decision feedback and designed for binary transmission is introduced. In contrast to conventional decision-feedback equalization (DFE), iterations are necessary, because a simple matched filter serves as feedforward filter, which collects signal energy, but creates noncausal intersymbol interference. The rule for generating soft decisions is adapted continuously to the current state of the algorithm. In most cases, standard DFE methods are clearly outperformed. For a class of certain channel impulse responses, performance of maximum-likelihood sequence estimation is attained, in principle. The high performance of the scheme is explained using results from neural network theory.
Iron and nitrogen-co-doped carbon quantum dots for the sensitive and selective detection of hematin and ferric ions and cell imaging (2021)

Iron, nitrogen-co-doped carbon quantum dots (Fe,N-CDs) were prepared via a simple one-step hydrothermal method. The quantum yield of fluorescence reached about 27.6% and the blue-emissive Fe,N-CDs had a mean size of 3.76 nm. The as-prepared carbon quantum dots showed good solubility, a high quantum yield, good biocompatibility, low cytotoxicity, and high photostability. Interestingly, the as-prepared Fe,N-CDs exhibited good selectivity and sensitivity toward both hematin and ferric ions, and the limit of detection for hematin and ferric ions was calculated to be about 0.024 μM and 0.64 μM, respectively. At the same time, Fe,N-CDs were used for imaging HeLa cells and showed that most Fe,N-CDs were detained in the lysosome. Thus, this fluorescent probe has potential application in the quantitative detection of hematin or Fe3+ in a complex environment and for determining Fe3+ at the cellular level.
Beam duality, with application to generalized Bessel-Gaussian, and Hermite- and Laguerre- Gaussian beams (2009)

The concept of the dual of a beam is discussed. The duals of Bessel-Gauss beams, elegant Hermite- or Laguerre-Gaussian beams and generalized Hermite- or Laguerre-Gauss beams are described. Duality is considered within the framework of hypergeometric beams in Cartesian and polar coordinates. The connection with the "modified Laguerre-Gauss" beam is discussed.
Digital watermarks for copyright protection (2002)

It is feared that the ease with which digital media can be copied will lead to a proliferation of copyright infringement. One proposed technical solution is digital watermarking, which embeds a hidden signal into host data that can be used in a variety of protocols that attempt to either prevent or deter copyright infringement. In this paper, we give a brief overview of digital watermarking and discuss some of the issues involved in providing effective digital watermarking systems for deterring copyright infringement.
MRI prior to systematic lymphadenectomy in patients with locally advanced cervical cancer. (2011)

5042 Background: Surgical evaluation of lymph node (LN) metastases has served as the gold standard for comparison of imaging modalities in locally advanced cervical cancers. It has been suggested that contemporary techniques such as MRI be relied upon for treatment planning and, specifically, extended-field radiation (EFRT) without pathologic confirmation. Methods: As part of a prospective, multicenter clinical trial conducted by ACRIN/GOG, patients (pts) with histologically confirmed, stage IB2, IIA≥4 cm, or IIB-IVA) cervical carcinoma underwent MRI prior to systematic pelvic (PLN) and abdominal (PALN) lymphadenectomy. LNs ≤ 1 cm were bisected while those > 1 cm were serially sectioned into 5 mm sections and a slide was made from each section. For positive & negative predictive values (PPV & NPV) of PALN on MRI, patients were grouped into those with MRI reports of both (+) PLN & PALN (G1), (+) PLN but (-)PALN (G2), and those with both (-) PLN & PALN (G3). Results: 33 pts are included in this analysis. Stage distribution was 12 1B2, 3 2A, 15 2B, 3 3B. 29 were squamous, 3 adeno, and 1 rhabdomyosarcoma. 94 (+) and 659 (-) LNs were removed. (+) LNs were found in the PALN in 12 (36%) and in the PLN in 22 (67%) pts. Two pts had PALN but not PLN metastases. The mean size of the long axis of the largest (+) (N=60) and (-) (N=209) LNs removed did not differ (18.7±9.3 vs. 18.7±11.6 mm; p=0.47). The size of the largest focus of metastasis within a LN ranged from 2-50 mm and was statistically larger in PLN compared to PALN (18 vs. 14 mm; p=0.02). The mean number of LNs counted by pathology was greater than the number reported on MRI (p <0.0001). For the above defined groups, the PPV for PALN in G1 was 0.61 (95% CI 0.48-0.73), the NPV for PALN in G2 was 0.66 (95% CI 0.55-0.75), and the NPV for PALNs in G3 was 0.86 (95% CI 0.76-0.92). Conclusions: PALN metastases are common in locally advanced cervical cancer. The NPV of MRI for PALN among pts reported to have negative PLN & PA LN on MRI is high enough that surgical evaluation and EFRT is not necessary. For all others, the PPV & NPV of MRI is too low to determine the need for EFRT without first performing surgical evaluation. This study was supported by NCI funding to the GOG (grants CA 27469 and CA 37517) and to ACRIN (grants U01 CA079778 and U01 CA080098).
Evidence for strong mixing between the LC and MLCT excited states in bis(2-phenylpyridinato-C2,N')(2,2'-bipyridine)iridium(III) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for strong mixing between the LC and MLCT excited states in bis(2-phenylpyridinato-C2,N')(2,2'-bipyridine)iridium(III)Mirco G. Colombo, Andreas Hauser, and Hans U. GuedelCite this: Inorg. Chem. 1993, 32, 14, 3088–3092Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ic00066a020https://doi.org/10.1021/ic00066a020research-articleACS PublicationsRequest reuse permissionsArticle Views1875Altmetric-Citations289LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients (2005)

Universal prophylaxis and preemptive strategies are beneficial in preventing CMV organ disease in solid organ transplant recipients. Both strategies are associated with a reduction in allograft rejection, but current data suggest that only universal prophylaxis reduces bacterial and fungal infections and death. Acyclovir and ganciclovir are both effective for universal prophylaxis.
Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells (2019)

Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a phenotype reminiscent of NPC1 mutant cells. Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting Rab7 inactivation via TBC1D15, a Rab7-GAP. In NPC1 mutant cells, AnxA6 depletion and eventual Rab7 activation was associated with peripheral distribution and increased mobility of late endosomes. This was accompanied by an enhanced lipid accumulation in lipid droplets in an acyl-CoA:cholesterol acyltransferase (ACAT)-dependent manner. Moreover, in AnxA6-deficient NPC1 mutant cells, Rab7-mediated rescue of late endosome-cholesterol export required the StAR-related lipid transfer domain-3 (StARD3) protein. Electron microscopy revealed a significant increase of membrane contact sites (MCS) between late endosomes and ER in NPC1 mutant cells lacking AnxA6, suggesting late endosome-cholesterol transfer to the ER via Rab7 and StARD3-dependent MCS formation. This study identifies AnxA6 as a novel gatekeeper that controls cellular distribution of late endosome-cholesterol via regulation of a Rab7-GAP and MCS formation.
Gingival recession defects and guided tissue regeneration: a review (2001)

The last decade has seen an increasing number of clinical reports on guided tissue regeneration (GTR) for reconstruction of gingival recession defects. This article reviews the value of GTR in the management of gingival recession defects based on records from such reports. Studies and case-series using nonresorbable and bioresorbable membranes, studies comparing GTR to the subepithelial connective tissue graft (CTG) procedure, and histologic reports of healing following GTR, published in the English language from 1985 to 2000, were identified using a Medline search and were included in the data-base for this review. The Following pre- and post-treatment data were collated and evaluated for each of the reports: gingival recession depth, probing depth, clinical attachment level, and width of the keratinized gingiva. In perspective of the limitations of the studies reviewed, it has been shown that GTR may be used for reconstruction of gingival recession detects. Importantly it has not been shown that GTR provides an added clinical benefit for the patient treatment planned for reconstruction of gingival recession defects. i.e. GTR does not appear to offer a significant advantage over mucogingival procedures such as the connective tissue graft or the advanced flap procedure. It is imperative to recognize inherent technical difficulties associated with GTR including primary would closure and secondary membrane exposure: membrane exposures being negatively correlated to desired clinical outcomes. Also, membrane exposures appear consistently more common in smokers than in non-smokers. It is also imperative to recognize shortcomings and adverse effects including space maintenance and unacceptable foreign body reactions associated with some bioresorbable GTR technologies.
Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells (2015)

We identified a molecular expression signature and pathway regulatory mechanisms in HCSCs with potential diagnostic and therapeutic value.
Measurement of <i>Helicobacter pylori</i> Using Anti Its Urease Monoclonal Antibody by Surface Plasmon Resonance (2000)

Adults over 70% of Japanese are infected by Helicobacter pylori causing chronic gastrisis and gastric ulcer. In this study, by employing a unique monoclonal antibody against Helicobacter pylori urease, the bacterium was detected down to 2×107 cell/ml using a SPR apparatus equipping two detecting cells. Ultrasonicated sample of Helicobacter pylori gave a huge improvement in the detection limit rather than the non-ultrasonicated sample by 100 fold. Escherichia coli was hardly detected, suggesting the specific detection of Helicobacter pylori by this measurement system. Using this type of SPR apparatus, the wider concentration of Helicobacter pylori could be detected comparing with the conventional assay kit, while the detection limit of the SPR system was worse by 10 fold.
EXPERIMENTAL STUDY ON THE BRITTLE FRACTURE OF BEAM-TO-COLUMN WELDED JOINT WITH END-TAB AND BACKING STRIP (1983)

This paper describes the exprimental results and the discussion about a brittle fracture in beam-to-column welded joints concerning following parameters ; disposal of end-tab, a mode of fillet weld at backing strip and stress ratio of beam flange and column flange T-type full scale specimens are used in tension and bending test in regard to those parameters. The results are shown as follows ; 1. Brittle fracture did not occure starting from tip of notch between end-tab and beam flange in any specimen. 2. In case of having continuous fillet weld at backing strip, brittle fracture did not occure at beam flange, but in some specimen brittle fracture occured at column flange starting from an intersection of fillet weld metal and column base metal. By making use of results obtaind in this experiment, we can say that there is nothing against in leaving end-tab as it is and that it is best to avoid fillet weld at backing strip.
Holographic visualization of low-frequency acoustic fields (1977)

A novel optical holographic method has been developed which uses conventional films for the visualization and measurement of low-frequency sound fields. The method uses two nearly coincident optic beams, instead of the single beam used in schlieren optical methods, to produce a gratinglike image plane hologram. Two holograms are superposed and then optically processed to reconstruct an image of the visualization area. The reconstructed image contains a pattern of optical interference fringes which characterize the sound field. If the acoustic pressure is constant in one direction, the interference fringes can be interpreted in a particularly simple way: as contours of equal instantaneous acoustic pressure. Sensitivities of the order of 196 dB re 1 μPa are achieved. Results obtained with the new holographic visualization method are compared with those of classical schlieren visualization methods. The new holographic visualization method is found to have better sensitivity, dynamic range, and spatial resolution than schlieren methods at frequencies of most practical interest in underwater and evironmental acoustics problems (below 50 kHz). The new method could find important application to experimental investigations of the nearfield of objects radiating or scattering sound at audio and sonar frequencies.
Measurement of the ultraviolet doses received by office workers (1978)

Journal Article Measurement of the ultraviolet doses received by office workers Get access J.F. LEACH, J.F. LEACH British Aircraft Corporation Limited, Commercial Aircraft Division, G.P.O. Box 77, Filton House, Bristol bs99 7ar Search for other works by this author on: Oxford Academic Google Scholar V.E. McLEOD, V.E. McLEOD British Aircraft Corporation Limited, Commercial Aircraft Division, G.P.O. Box 77, Filton House, Bristol bs99 7ar Search for other works by this author on: Oxford Academic Google Scholar A.R. PINGSTONE, A.R. PINGSTONE British Aircraft Corporation Limited, Commercial Aircraft Division, G.P.O. Box 77, Filton House, Bristol bs99 7ar Search for other works by this author on: Oxford Academic Google Scholar A. DAVIS, A. DAVIS Procurement Executive, Ministry of Defence, Propellants, Explosives and Rocket Motor Establishment, Powdermill Lane, Wall ham Abbey, Essex EN9 IBP Search for other works by this author on: Oxford Academic Google Scholar G.H.W. DEANE G.H.W. DEANE Procurement Executive, Ministry of Defence, Propellants, Explosives and Rocket Motor Establishment, Powdermill Lane, Wall ham Abbey, Essex EN9 IBP Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 3, Issue 1, 1 March 1978, Pages 77–79, https://doi.org/10.1111/j.1365-2230.1978.tb01463.x Published: 01 March 1978 Article history Accepted: 22 August 1977 Published: 01 March 1978
Immunoscintigraphy with131I-labelled monoclonal antibodies HMFG2 and HMFG1 F(ab')2 versus abdominal CT scan in the detection of residual disease in ovarian cancer patients (1988)

131I-labelled HMFG2 or HMFG1 F(ab')2 monoclonal antibody (MAb) was administered intraperitoneally to 15 patients with epithelial ovarian cancer who had completed chemotherapy and were in complete or good partial remission. Each patient received 2-3 mCi. Patients were scanned immediately after and until 7 days post-injection. In 3/15 patients the immunoscan failed because extensive adhesions from the previous surgery prevented MAb diffusion. Of the remaining 12 patients, 9 underwent second-look laparotomy (SL). Immunoscan was true positive in 8/9 (89%) patients and equivocal in 1/9 (11%), whereas the abdominal CT scan gave true positive results in 6/9 (67%) patients. In 8 out of 9 patients there was a good correlation between distribution of all sites of abnormal uptake and the surgical findings at SL. Of the 3 patients not undergoing SL, the immunoscan was positive in all, whereas clinical examination and abdominal CT scan were negative. All 3 patients relapsed after 3, 4 and 5 months. Thus the total true positivity of immunoscan reached 92%, CT scan remaining at 50%. Immunoscan with intraperitoneal administration of 131I-labelled MAbs can thus accurately detect the presence of residual disease in ovarian cancer patients and appears more sensitive than abdominal CT scan.
Generative Adversarial Neural Operators (2022)

We propose the generative adversarial neural operator (GANO), a generative model paradigm for learning probabilities on infinite-dimensional function spaces. The natural sciences and engineering are known to have many types of data that are sampled from infinite-dimensional function spaces, where classical finite-dimensional deep generative adversarial networks (GANs) may not be directly applicable. GANO generalizes the GAN framework and allows for the sampling of functions by learning push-forward operator maps in infinite-dimensional spaces. GANO consists of two main components, a generator neural operator and a discriminator neural functional. The inputs to the generator are samples of functions from a user-specified probability measure, e.g., Gaussian random field (GRF), and the generator outputs are synthetic data functions. The input to the discriminator is either a real or synthetic data function. In this work, we instantiate GANO using the Wasserstein criterion and show how the Wasserstein loss can be computed in infinite-dimensional spaces. We empirically study GANO in controlled cases where both input and output functions are samples from GRFs and compare its performance to the finite-dimensional counterpart GAN. We empirically study the efficacy of GANO on real-world function data of volcanic activities and show its superior performance over GAN.
Aspetti costruttivi del Campanile di Giotto (2017)

Analisi dei materiali impiegati nelle costruzione del Campanile di Giotto e loro provenienze e lavorazioni, apparecchio murario lapideo, stato della conoscenza sulle fondazioni, la successione degli artefici e le variazioni progettuali avvenute, i ringrossi murari e le rastremazioni nell'elevato, il problema della conclusione interrotta e del rapporto con la cattedrale.
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA (2023)

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy<sup>1</sup>. The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study<sup>2</sup>. A lack of preoperative ctDNA detection distinguished biologically indolent lung adenocarcinoma with good clinical outcome. Postoperative plasma analyses were interpreted within the context of standard-of-care radiological surveillance and administration of cytotoxic adjuvant therapy. Landmark analyses of plasma samples collected within 120 days after surgery revealed ctDNA detection in 25% of patients, including 49% of all patients who experienced clinical relapse; 3 to 6 monthly ctDNA surveillance identified impending disease relapse in an additional 20% of landmark-negative patients. We developed a bioinformatic tool (ECLIPSE) for non-invasive tracking of subclonal architecture at low ctDNA levels. ECLIPSE identified patients with polyclonal metastatic dissemination, which was associated with a poor clinical outcome. By measuring subclone cancer cell fractions in preoperative plasma, we found that subclones seeding future metastases were significantly more expanded compared with non-metastatic subclones. Our findings will support (neo)adjuvant trial advances and provide insights into the process of metastatic dissemination using low-ctDNA-level liquid biopsy.
Supplementary Figure S2 from PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates (2023)

&lt;p&gt;Supplementary Figure S2. Autoradiography of whole mounted KLK3_Hi-MYC GEMM prostate sections obtained 120h p.i. of [89Zr]hu5A10 (A) or [90Y]hu5A10 (B). Radioimmunoconjugate activity was detected in regions expressing PSA, but not in adjacent tissues lacking PSA expression, such as seminal vesicles and urethra.&lt;/p&gt;
Implicit Manifold Learning on Generative Adversarial Networks (2017)

This paper raises an implicit manifold learning perspective in Generative Adversarial Networks (GANs), by studying how the support of the learned distribution, modelled as a submanifold $\mathcal{M}_θ$, perfectly match with $\mathcal{M}_{r}$, the support of the real data distribution. We show that optimizing Jensen-Shannon divergence forces $\mathcal{M}_θ$ to perfectly match with $\mathcal{M}_{r}$, while optimizing Wasserstein distance does not. On the other hand, by comparing the gradients of the Jensen-Shannon divergence and the Wasserstein distances ($W_1$ and $W_2^2$) in their primal forms, we conjecture that Wasserstein $W_2^2$ may enjoy desirable properties such as reduced mode collapse. It is therefore interesting to design new distances that inherit the best from both distances.
High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication (2016)

High efficiency fabrication and integration of three-dimension (3D) functional devices in Lab-on-a-chip systems are crucial for microfluidic applications. Here, a spatial light modulator (SLM)-based multifoci parallel femtosecond laser scanning technology was proposed to integrate microstructures inside a given 'Y' shape microchannel. The key novelty of our approach lies on rapidly integrating 3D microdevices inside a microchip for the first time, which significantly reduces the fabrication time. The high quality integration of various 2D-3D microstructures was ensured by quantitatively optimizing the experimental conditions including prebaking time, laser power and developing time. To verify the designable and versatile capability of this method for integrating functional 3D microdevices in microchannel, a series of microfilters with adjustable pore sizes from 12.2 μm to 6.7 μm were fabricated to demonstrate selective filtering of the polystyrene (PS) particles and cancer cells with different sizes. The filter can be cleaned by reversing the flow and reused for many times. This technology will advance the fabrication technique of 3D integrated microfluidic and optofluidic chips.