gebhart/patrepeval huggingface dataset:
Working While Narcoleptic (2013)

As a young person with narcolepsy, the author chronicles some of the challenges and hopes of being in the workforce. These journal entries center around the issues created by excessive daytime sleepiness and the experiences that drive the narrator to become self-employed.
Plasmonic AuNP/g-C3N4Nanohybrid-based Photoelectrochemical Sensing Platform for Ultrasensitive Monitoring of Polynucleotide Kinase Activity Accompanying DNAzyme-Catalyzed Precipitation Amplification (2015)

A convenient and feasible photoelectrochemical (PEC) sensing platform based on gold nanoparticles-decorated g-C3N4 nanosheets (AuNP/g-C3N4) was designed for highly sensitive monitoring of T4 polynucleotide kinase (PNK) activity, using DNAzyme-mediated catalytic precipitation amplification. To realize our design, the AuNP/g-C3N4 nanohybrid was initially synthesized through in situ reduction of Au(III) on the g-C3N4 nanosheets, which was utilized for the immobilization of hairpin DNA1 (HP1) on the sensing interface. Thereafter, a target-induced isothermal amplification was automatically carried out on hairpin DNA2 (HP2) in the solution phase through PNK-catalyzed 5'-phosphorylation accompanying formation of numerous trigger DNA fragments, which could induce generation of hemin/G-quadruplex-based DNAzyme on hairpin DNA1. Subsequently, the DNAzyme could catalyze the 4-chloro-1-naphthol (4-CN) oxidation to produce an insoluble precipitation on the AuNP/g-C3N4 surface, thereby resulting in the local alternation of the photocurrent. Experimental results revealed that introduction of AuNP on the g-C3N4 could cause a ∼100% increase in the photocurrent because of surface plasmon resonance-enhanced light harvesting and separation of photogenerated e-/h+ pairs. Under the optimal conditions, the percentage of photocurrent decrement (ΔI/I0, relative to background signal) increased with the increasing PNK activity in a dynamic working range from 2 to 100 mU mL(-1) with a low detection limit (LOD) of 1.0 mU mL(-1). The inhibition effect of adenosine diphosphate also received a good performance in PNK inhibitor screening research, thereby providing a useful scheme for practical use in quantitative PNK activity assay for life science and biological research.
An Optimal Algorithm for Monte Carlo Estimation (2000)

A typical approach to estimate an unknown quantity $\mu$ is to design an experiment that produces a random variable Z, distributed in [0,1] with E[Z]=\mu$, run this experiment independently a number of times, and use the average of the outcomes as the estimate. In this paper, we consider the case when no a priori information about Z is known except that is distributed in [0,1]. We describe an approximation algorithm ${\cal A}{\cal A}$ which, given $\epsilon$ and $\delta$, when running independent experiments with respect to any Z, produces an estimate that is within a factor $1+\epsilon$ of $\mu$ with probability at least $1-\delta$. We prove that the expected number of experiments run by ${\cal A}{\cal A}$ (which depends on Z) is optimal to within a constant factor {for every} Z.
Tailoring Reflections From Thin Composite Metamirrors (2014)

We propose an effective route to fully control the phase of plane waves reflected from electrically (optically) thin composite sheets. This becomes possible using engineered artificial full-reflection layers (metamirrors) formed by arrays of electrically small resonant bi-anisotropic particles. In this scenario, fully reflecting mirrors do not contain any continuous ground plane, but only arrays of small particles. Bi-anisotropic omega coupling is required to get asymmetric response in reflection phase for plane waves incident from the opposite sides of the composite mirror. It is shown that with this concept one can independently tailor the phase of electromagnetic waves reflected from both sides of the mirror array.
How capillarity affects the propagation of elastic waves in soft gels (2020)

Elastic waves propagating at the interface of soft solids can be altered by the presence of external forces such as capillarity and gravity. We measure the dispersion relation of waves at the free surface of agarose gels with great accuracy, revealing the existence of multiple modes as well as an apparent dispersion. We disentangle the role of capillarity and elasticity by considering the three-dimensional nature of mechanical waves, achieving quantitative agreement between theoretical predictions and experiments. Notably, our results show that capillarity plays an important role for wave numbers smaller than expected from balancing elastic and capillary forces. We further confirm the efficiency of our approach by including the effect of gravity in our predictions and quantitatively comparing it to experiments.
Ultra Compact Athermal 400G-FR4 Silicon Photonics Receiver with Polarization Diversity (2022)

We have successfully demonstrated an ultra-compact WDM 400G-FR4 ROSA module integrated with silicon photonics circuits operating at 53.125Gbaud PAM4 signal with a sensitivity of -6.0dBm optical modulation amplitude at KP4 Pre-FEC-BER=2.4e-4.
Thumbnail-Preserving Encryption for JPEG (2015)

With more and more data being stored in the cloud, securing multimedia data is becoming increasingly important. Use of existing encryption methods with cloud services is possible, but makes many web-based applications difficult or impossible to use. In this paper, we propose a new image encryption scheme specially designed to protect JPEG images in cloud photo storage services. Our technique allows efficient reconstruction of an accurate low-resolution thumbnail from the ciphertext image, but aims to prevent the extraction of any more detailed information. This will allow efficient storage and retrieval of image data in the cloud but protect its contents from outside hackers or snooping cloud administrators. Experiments of the proposed approach using an online selfie database show that it can achieve a good balance of privacy, utility, image quality, and file size.
Advanced Silicon Chemistry in Australia: Forming Strong Links with Asia (2017)

This paper details Australian commercial and academic silicon research. Areas of interest include silicon metal, polysiloxane polymers, copolymers, cyclics, emulsions, microemulsions, silanes, silane coupling agents, sol-gel chemistry and water-treatments, porous silicon, polysiloxane degradation, silicon hydrogel contact lenses, silanolate synthesis, siloxane interfacial polymerisation, hydrosilylation, polysiloxane electrolytes for lithium ion batteries, silanes for PBX materials, octafunctionalized polyhedral oligomeric silsesquioxanes (POSS), POSS hybrids, sol-gel hydrogenation catalysts, silane modification of silica, sol-gel energy storage, silicate grout stabilisation, GeoPolymer concretes, aerogel insulating foams, "Phaco-Ersatz" Accommodating Gel-Intraocular Lens technologies. Strong collaborative opportunities, in silicon, with Asia, exist with organisations such as: 1) The Asian Silicon Society and 2) The Agency for the Assessment and Application of Technology (BPPT) Indonesia.
Speech-processing strategies designed for children (1997)

The design of cochlear prosthetic hardware and speech-processing strategies has been driven largely by psychophysical data from postlingually deafened adults with implants. In such subjects, success is related to the ability of the electrical stimulation to evoke the same patterns of neural activity and hence the same percepts as were produced formerly by acoustic input. Adults differ greatly in their ability to make use of information provided through electrical stimulation, particularly as temporal patterns. Recent research suggests that the manner in which information is processed in the auditory nervous system can be influenced by the type of information that is available during development of hearing. Because cochlear prostheses are used increasingly in prelingually deaf children, we must face the difficult task of designing and testing speech-processing strategies that are more appropriate for developing nervous systems whose first and only experience with sound comes from electrical stimulation.
Non‐covalent binding of the heavy atom compound [Au(CN)2]− at the halide binding site of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10 (1993)

The Na[Au(CN)2] heavy atom derivative contributed considerably to the successful elucidation of the crystal structure of haloalkane dehalogenase isolated from Xanthobacter autotrophicus GJ10. The gold cyanide was located in an internal cavity of the enzyme, which also contains the catalytic residues. Refinement of the dehalogenase-gold cyanide complex at 0.25 nm to an R-factor of 16.7% demonstrates that the heavy atom molecule binds non-covalently between two tryptophan residues pointing into the active site cavity. At this same site also chloride ions can be bound. Therefore, inhibition of dehalogenase activity by the Au(CN)-2 presumably occurs by competition for the same binding site as substrates.
Powder-Based Additive Manufacturing of Li-Ion Batteries and Micropowder Mixing Characteristics (2017)

Lithium ion battery electrodes were manufactured using a new additive manufacturing process based on dry powders. By using dry powder based process, solvent and drying process used in conventional battery process can be removed which allows large-scale Li-ion battery production be more economically viable in markets such as automotive energy storage systems. Thermal activation time has been greatly reduced due to the time and resource demanding solvent evaporation process needed with slurry-cast electrode manufacturing being replaced by a hot rolling process. It has been found that thermal activation time to induce mechanical bonding of the thermoplastic polymer to the remaining active electrode particles is only a few seconds. By measuring the surface energies of various powders and numerical simulation of powder mixing, the powder mixing and binder distribution, which plays a vital role in determining the quality of additive manufactured battery electrodes, have been predicted and compared favorably with experiments.
Long Noncoding RNAs in Atherosclerosis and Vascular Injury (2020)

Despite major advances in the primary and secondary prevention of atherosclerosis and its risk factors, atherosclerotic cardiovascular disease remains a major clinical and financial burden on individuals and health systems worldwide. In addition, neointima formation and proliferation due to mechanical trauma to the vessel wall during percutaneous coronary interventions can lead to vascular restenosis and limit the longevity and effectiveness of coronary revascularization. Long noncoding RNAs (lncRNAs) have emerged as a novel class of epigenetic regulators with critical roles in the pathogenesis of atherosclerosis and restenosis following vascular injury. Here, we provide an in-depth review of lncRNAs that regulate the development of atherosclerosis or contribute to the pathogenesis of restenosis following mechanical vascular injury. We describe the diverse array of intracellular mechanisms by which lncRNAs exert their regulatory effects. We highlight the utility and challenges of lncRNAs as biomarkers. Finally, we discuss the immense translational potential of lncRNAs and strategies for targeting them therapeutically using oligonucleotide-based therapeutics and novel gene therapy platforms.
Process Design and Economics of On-Site Cellulase Production on Various Carbon Sources in a Softwood-Based Ethanol Plant (2010)

On-site cellulase enzyme fermentation in a softwood-to-ethanol process, based on SO(2)-catalysed steam pretreatment followed by simultaneous saccharification and fermentation, was investigated from a techno-economic aspect using Aspen Plus© and Aspen Icarus Process Evaluator© softwares. The effect of varying the carbon source of enzyme fermentation, at constant protein and mycelium yields, was monitored through the whole process. Enzyme production step decreased the overall ethanol yield (270 L/dry tonne of raw material in the case of purchased enzymes) by 5-16 L/tonne. Capital cost was found to be the main cost contributor to enzyme fermentation, constituting to 60-78% of the enzyme production cost, which was in the range of 0.42-0.53 SEK/L ethanol. The lowest minimum ethanol selling prices (4.71 and 4.82 SEK/L) were obtained in those scenarios, where pretreated liquid fraction supplemented with molasses was used as carbon source. In some scenarios, on-site enzyme fermentation was found to be a feasible alternative.
Support Vector Machine Training for Improved Hidden Markov Modeling (2007)

We present a discriminative training algorithm, that uses support vector machines (SVMs), to improve the classification of discrete and continuous output probability hidden Markov models (HMMs). The algorithm uses a set of maximum-likelihood (ML) trained HMM models as a baseline system, and an SVM training scheme to rescore the results of the baseline HMMs. It turns out that the rescoring model can be represented as an unnormalized HMM. We describe two algorithms for training the unnormalized HMM models for both the discrete and continuous cases. One of the algorithms results in a single set of unnormalized HMMs that can be used in the standard recognition procedure (the Viterbi recognizer), as if they were plain HMMs. We use a toy problem and an isolated noisy digit recognition task to compare our new method to standard ML training. Our experiments show that SVM rescoring of hidden Markov models typically reduces the error rate significantly compared to standard ML training.
MODELING OF THE TRANSPORT PHENOMENA IN THE ANODE REGION OF HIGH CURRENT ARCS (1985)

The coupled transport phenomena in the anode region of wall-stabilized high-current D.C. arcs are described by a set of differential conservation equations. These equations are solved numerically using experimentally derived conditions. Solutions are obtained for atmospheric pressure nitrogen and argon arcs operated at different arc currents. Considering the anode mechanism of wall-stabilized arcs without the influence of a superimposed plasma flow from the cathode, the results indicate that nitrogen arcs tend to form constricted anode arc roots in contrast to argon arcs.
Variational Theory of Nonrelativistic Quantum Electrodynamics (2019)

The ability to achieve ultrastrong coupling between light and matter promises to bring about new means to control material properties, new concepts for manipulating light at the atomic scale, and new insights into quantum electrodynamics (QED). Thus, there is a need to develop quantitative theories of QED phenomena in complex electronic and photonic systems. In this Letter, we develop a variational theory of general non-relativistic QED systems of coupled light and matter. Essential to our Ansatz is the notion of an effective photonic vacuum whose modes are different than the modes in the absence of light-matter coupling. This variational formulation leads to a set of general equations that can describe the ground state of multielectron systems coupled to many photonic modes in real space. As a first step toward a new ab initio approach to ground and excited state energies in QED, we apply our Ansatz to describe a multilevel emitter coupled to many optical modes, a system with no analytical solution. We find a compact semianalytical formula which describes ground and excited state energies very well in all regimes of coupling parameters allowed by sum rules. Our formulation provides a nonperturbative theory of Lamb shifts and Casimir-Polder forces, as well as suggest new physical concepts such as the Casimir energy of a single atom in a cavity. Our method thus give rise to highly accurate nonperturbative descriptions of many other phenomena in general QED systems.
Non-invasive characterization of pancoronary inflammation by computed tomography angiography in patients with recent spontaneous coronary dissection (2022)

Abstract Background Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction of unclear aethiology. Histopathological analyses have identified increased coronary inflammation in patients with SCAD [1]. Recently the peri-coronary adipose tissue attenuation (PCAT) derived from standard computed tomography angiography (CTA) has been established as a reproducible method for measuring vascular inflammation which enhances risk stratification in patients with coronary atherosclerosis [2]. Purpose To characterize the pancoronary and vessel-specific inflammation by means of CTA-derived PCAT in patients with recent SCAD compared with individuals without prior SCAD. Methods Patients with confirmed SCAD referred to a tertiary center between 2017 and 2021 who underwent CTA as a routine cardiac evaluation were included in this retrospective study. Subjects were matched 1:1 with individuals with no prior SCAD who underwent CTA within the same timespan, using the same scanner and imaging protocol, with coronary arteries free of obstructive disease and similar clinical characteristics (Table 1). PCAT was analyzed on end-diastolic CTA reconstructions with a semi-automated software using standard methodology (Figure 1A) [3]. Proximal 40 mm of all major coronary vessels &amp;gt;2 mm in diameter as well as the SCAD-related vessel were included. The primary outcome was pancoronary PCAT defined as mean PCAT in the right (RCA), left anterior descending (LAD) and circumflex (LCX) artery. Secondary outcome was vessel-specific PCAT defined as PCAT in RCA and averaged PCAT in LAD and LCX (PCAT LCA). Results The final cohort comprised 35 patients with recent SCAD (median 6.1 mo. [4.0–16.8] since SCAD, 94.3% female) and 35 patients in the non-SCAD group. Pancoronary PCAT was higher in patients with SCAD compared with non-SCAD group (−80.1 [IQR: −74.5, −84.6] vs. −83.4 HU [−78.7, −88.0], P=0.008) suggestive of increased coronary inflammation. Vessel-specific PCAT was higher for the RCA (−80.7 [−70.4, −86.9] vs. −85.3 [−80.4, −90.6] HU, P&amp;lt;0.001) and borderline higher for the LCA (−79.2 [−73.9, −83.2] vs. −83.4 [−78.0, −88.3] HU, P=0.056) in patients with SCAD compared with non-SCAD respectively (Figure 1B). In patients with SCAD, PCAT in previously dissected vessel was not significantly different from averaged PCAT in unaffected vessels (−78.4 [−73.7, −89.0] vs. −80.9 [−74.9, −83.3], P=0.77; Figure 1C). While PCAT numerically decreased with time since SCAD, the association was not statistically significant when patients were stratified into tertiles according to time from SCAD (Figure 1D). Conclusions Patients with recent SCAD have higher pericoronary adipose tissue attenuation compared with non-SCAD patients suggesting increased perivascular inflammatory activity. This association is not restricted to the dissected vessel, nor reflected in routine serum inflammatory analysis and persists over time. Funding Acknowledgement Type of funding sources: None.
ChemInform Abstract: STUDY ON ANTIBLASTIC SUBSTANCES. LXI. SYNTHESIS OF DERIVATIVES OF 6‐AMINO‐ AND 7‐AMINO‐9‐OXO‐9H‐PYRROLO(1,2‐A)INDOLE (1978)

Abstract Die Nitroanthranilsäuren (I) reagieren mit Diethoxytetrahydrofuran (II) zu den Pyrrol‐Derivaten (III).
EVALUATION OF PHOSPHORIC ACID FOR STABILIZATION OF FINE- GRAINED PLASTIC SOILS (1962)

A LABORATORY STUDY WAS MADE ON THE EFFECTIVENESS OF PHOSPHORIC ACID IN IMPROVING THE ENGINEERING PROPERTIES OF SIX FINE-GRAINED PLASTIC SOILS. THE PROPERTIES STUDIED INCLUDE PLASTICITY, MOISTURE AND DENSITY RELATIONS, VOLUME CHANGE, AND UNCONFINED COMPRESSIVE STRENGTH. THE ACID WAS APPLIED AT RATES UP TO 4 PERCENT OF THE WEIGHT OF DRY SOIL. TESTS WERE ALSO MADE USING 0.5 PERCENT OF AN AMINE COMPOUND AS A SUPPLEMENT TO THE ACID. IN GENERAL, PLASTIC PROPERTIES WERE MODERATELY AFFECTED, AND THERE WAS LITTLE CHANGE IN MOISTURE-DENSITY RELATIONSHIPS. PRONOUNCED INCREASES IN UNCONFINED COMPRESSIVE STRENGTH OF SOAKED SPECIMENS WERE OBTAINED FOR MOST OF THE SOILS WHEN TREATED WITH ACID ALONE, AND SLIGHT ADDITIONAL INCREASES RESULTED WHEN THE AMINE WAS ALSO USED. VOLUME CHANGE, AS MEASURED FOR FIVE OF THE SOILS, WAS REDUCED TO A LEVEL CONSIDERED SATISFACTORY. USING 2 PERCENT OF THE ACID AND 0.5 PERCENT OF THE AMINE, A COMPRESSIVE STRENGTH OF 184 PSI WAS OBTAINED FOR THE PENN SOIL, WHICH HAD NO STRENGTH BEFORE TREATMENT. ALTHOUGH STRENGTH GAINS FOR TWO OF THE REMAINING SOILS WERE NOT OF PRACTICAL MAGNITUDE, GAINS FOR THE OTHER THREE WERE QUITE SUFFICIENT TO INDICATE THAT PHOSPHORIC ACID OFFERS CONSIDERABLE PROMISE AS A STABILIZER FOR A WIDE VARIETY OF FINE-GRAINED PLASTIC SOILS. /AUTHOR/
Experimental and theoretical study of nonlinear heat transport at the ends of a heated stack in a thermoacoustic prime-mover (2018)

International audience
Recording and Analysis of Peripheral Nerve Activity Using Multi-Electrode Array (2016)

신경보철 의수를 제어하기 위해서는 말초 신경신호를 측정하고 분석함으로써 사용자의 동작의도를 인식해야 한다. 본 논문에서는 다채널 신경전극 어레이, 전극 삽입 장치, 신경신호 증폭기로 구성된 말초 신경신호 측정 시스템을 제안한다. 마취상태에서 전극 삽입 장치를 이용하여 16 채널의 신경전극 어레이를 백서의 좌골신경에 안정적으로 삽입하였다. 수동적 관절 운동을 유도하거나 기계적 피부 자극을 인가하였을 때, 신경신호 증폭기를 통해 근육 또는 피부 감각 신경신호가 측정됨을 확인하였다. 또한, 개별 신경 단위를 분리하기 위해 활동전위 분류방법을 제안한다. 근육의 내부 수용기들은 근방추와 골지건 기관 수용기로 구분되었으며, 피부의 외부 수용기들은 완만적응과 급속적응 수용기로 분리되었다. 이와 같은 실험결과는 제안한 방법이 신경보철 시스템에서 말초 신경신호의 측정과 분석에 적용될 수 있음을 보였다. Reliable recording and analysis of peripheral nerve activity is important to recognize the user's intention for controlling a neuro-prosthetic hand. In this paper, we present a peripheral nerve recording system that consisted of an intrafascicular multi-electrode array, an electrode insertion device, and a multi-channel neural amplifier. The 16 channel multi-electrode array was stably implanted into the sciatic nerve of the rat under anesthesia using the electrode insertion device. During passive movements and mechanical stimuli, muscle and cutaneous afferent signals were recorded with the multi-channel neural amplifier. Furthermore, we propose a spike sorting method to isolate individual neuronal unit. The muscle proprioceptive units were classified as muscle spindle afferents or Golgi tendon organ afferents, and the skin exteroceptive units were categorized as slow adapting afferents or fast adapting afferents. Experimental results showed that the proposed method could be applicable to record and analyze peripheral nerve activity in neuro-prosthetic systems.
Innate cytokine profile in patients with complex regional pain syndrome is normal (2001)

Complex regional pain syndrome (CRPS) is a disabling disease characterized by the classic symptoms and signs of inflammation. In this study we investigated the innate cytokine profile in patients with CRPS to determine a possible role of the immune system in the pathophysiology of CRPS. The cytokine profile before and after lipopolysaccharide and thrombin stimulation was determined in 26 severely affected CRPS patients and 20 healthy controls. No difference in the production of pro- and anti- inflammatory cytokines between patients and controls was found. Hence, our results do not support a role of genetic factors responsible for the cytokine profile in the pathophysiology of CRPS. These findings encourage further investigations of mechanisms responsible for neurogenic-induced inflammation.