gebhart/patrepeval huggingface dataset:
Scatter in input impedance spectrum may result from the elastic nonlinearity of the arterial wall (1995)

We have examined the role of the nonlinear elastic properties of the arterial wall on the human aortic input impedance obtained at different heart rates and different pressure and flow wave shapes. Pressure and flow were taken from a computer model that provides realistic simulations of the nonlinear distributed systemic arterial tree. Different wave shapes of ascending aorta pressure and flow and different heart rates were used to derive input impedance moduli and phase angles via Fourier analysis. The results show that the nonlinear elastic properties of the arterial wall are responsible for significant variations in the input impedance spectrum when changes in heart rate and aortic flow wave shape take place. This finding may explain the scatter often observed in experimentally determined input impedance data using different heart rates obtained by pacing.
Macbecins I and II, new antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activities. (1980)

New antibiotics, macbecins I and II, have been found in the culture fluid of an actinomycete, which has the following properties: delayed fragmentation of vegetative mycelia, formation of coremia on solid media, the occurrence of meso-diaminopimelic acid in the cell wall, lysozyme resistance, and guanine-cytosine content of 71 +/- 1 mol%. The organism has been designated Nocardia sp. No. C-14919 (N-2001). A marked enhancement of the production of macbecins I and II was observed in cultures containing L-tyrosine. The antibiotics are moderately active against several Gram-positive bacteria and fungi. The antibiotics also inhibit the growth of Tetrahymena pyriformis W at 2 microgram/ml but show no activity against the regeneration of cilia in partially deciliated Tetrahymena at 10 microgram/ml.
Umbilical Cord Blood Platelet Lysate as Serum Substitute in Expansion of Human Mesenchymal Stem Cells. (2017)

PB-PL and UCB-PL both were potent in hMSCs proliferation. However, PB promoted osteoblastic differentiation and UCB-PL induced chondrogenic differentiation. Because of availability, ease of use and feasible standardization of UCB-PL, we have suggested that UCB-PL be used as an alternative to FBS and PB-PL for the cultivation and expansion of hMSCs in cellular therapy.
Does Local Administration of Liposomal Bupivacaine Reduce Pain and Narcotic Consumption in Adult Spinal Deformity Surgery? (2020)

The use of LB in adult spinal deformity surgery does not appear to provide clinically important improvements in postoperative pain at the manufacturer's recommended dosage. Furthermore, while patients receiving LB may transition more quickly off of IV narcotics, this does not appear to translate into an overall decrease in narcotic consumption, hasten return of bowel function, or decrease hospital lengths of stay. Future prospective randomized control trials are warranted. The use of varying dosages of LB may also help further clarify the true efficacy of LB in the setting of spinal deformity surgery.
The Glycine Box:  A Determinant of Specificity for Fibroblast Growth Factor (1998)

Acidic fibroblast growth factor (FGF-1), keratinocyte growth factor (FGF-7), and FGF-10 are homologues with distinct specificity. In the presence of heparin, FGF-1 binds and activates in vitro all FGFR subtypes, while FGF-7 exhibits absolute specificity for the IIIb splice variant of FGFR2. FGF-10 exhibits a similar specificity but also binds the FGFR1IIIb isoform. Neither FGF-7 nor FGF-10 will bind to IIIc isoforms of FGFR. Molecular models of FGF, heparin, and the FGFR ectodomain suggested that sequences between beta-strands 10 and 12 of FGF may be important for the interaction of FGF with the heparin-FGFR ectodomain duplex. Site-directed mutants of FGF-7 and FGF-10 were prepared to test whether this domain might underlie failure of FGF-7 and FGF-10 to bind to the FGFRIIIc isoforms. Constructions with substitution of FGF-1 sequences spanning the entire C-terminus encoded in exon 3 or only C-terminal sequences spanning beta-strands 10 through 12 conferred ability on FGF-7 to bind to and activate FGFRIIIc without a significant loss in binding to or activation of FGFR2IIIb. A series of twelve different substitutions of shorter segments of FGF-1 sequences into the C-terminal portion of FGF-7 or FGF-10 revealed that substitution of GSCKRG for GIPVRG or the tri-peptide sequence KKN for NQK just N-terminal to it conferred dual activities on both the FGF-7 and FGF-10 backbones. The results suggest that the combined sequence domain, which we call the FGF glycine box (G-box), is a major determinant for the specificity of the binding of FGF to heparan sulfate-FGFR duplexes.
Identification of agronomical and morphological traits contributing to drought stress tolerance in soybean (2019)

Abiotic stresses, especially drought, may seriously affect soybean yield. Due to the complexity of drought tolerance, one of the difficulties in selecting genotypes is the identification of traits contributing to improve stress tolerance. This study carried out soybean phenotyping under water deficit in vegetative and reproductive stages in field conditions at two consecutive crop seasons (2012/13 and 2013/14). The experiment was performed in Londrina, PR, Brazil, with two soybean cultivars with distinct levels of drought tolerance, BR 16 (sensitive) and Embrapa 48 (less sensitive). Water deficit was applied through rainout shelters, moving on rails to cover plots when the rainfall begins and uncover them when it ends. Then, some agronomic and morphological traits were measured. Multivariate statistics through the principal component analysis (PCA) associated with the biplot graph identified traits contributing to greater yield stability under drought. Result showed that water deficit affected soybean yield, mainly in the reproductive stage, in which Embrapa 48 had greater yield stability when compared to BR 16. However, opposite results were obtained for stress induced in the vegetative stage, when Embrapa 48 was more negatively affected than BR16 cultivar. Seed weight influenced yield differences between cultivars. Lighter seeds, but in larger number, constituted an advantage under water deficit. Due to the difficulty in introducing all drought tolerance mechanisms in one genotype, breeding programs need to define selection parameters according to regional drought conditions.
Strain of Staphylococcus Attractive to Laboratory Strain Anastrepha ludens (Diptera: Tephritidae) (1991)

A bacterium isolated from the mouthparts of a laboratory-culture female Mexican fruit fly, Anastrepha ludens (Loew), was highly attractive to sugar-fed, protein-starved, 4–16-d-old male and female laboratory-cultured Mexican fruit flies. The bacterium was identified as a strain of Staphylococcus (RGM-1) matching most closely to S. aureus. This is the first report of a Staphylococcus attractive to a tephritid species. Four S. aureus strains purchased from the American Type Culture Collection were as attractive to A. ludens as RGM-1. Tryptic soy broth cultures of RGM-1 were compared with torula yeast-borax, a standard bait for Anastrepha, for attractiveness to Mexican fruit flies. Bacterial preparations generally were less attractive or at best equally attractive as torula yeast-borax when baits were tested in pairs of competing McPhail traps in a greenhouse flight chamber and in a grapefruit orchard.
Influence of 1 alpha-hydroxycholecalciferol on calcium and phosphorus concentration in camel milk (1994)

International audience
Thermal stability and electrical properties of Zr/Si1−x−yGexCy contacts after rapid thermal annealing (1998)

In this work, we have investigated the reaction between Zr and SiGeC alloys. Annealings have been performed in a rapid thermal annealing (RTA) furnace at temperatures ranging from 400 to 800 °C for 5 min. The reaction of the metal with the alloy has been investigated by x-ray diffraction and Rutherford backscattering spectrometry. Four crystal x-ray diffraction was performed to measure the residual strain in the epilayer. The analyses indicate that the C49-Zr(Si1−xGex)2 is the final phase of the reaction. For all compositions examined (from 0% up to 33% of Ge), the C49 film has the same Ge content as in the as-deposited Si1−x−yGexCy layer and no Ge segregation has occured. In addition, this thermal treatment leads to only a small strain relaxation in the unreacted epilayer. The presence of C does not modify the reaction and it prevents any strain relaxation. Schottky barrier height measurements have been performed on p-type layers. RTA leads to a slight decrease of the barrier without any degradation of the contact. The C49 film presents a resistivity of about 80 μΩ cm. These results indicate that Zr may be a good candidate for contacts on IV–IV alloys in terms of thermal stability.
Onion and pizza (2013)

The traditional disk partitioning scheme commonly used in a virtualization system divides a disk into multiple partitions in a coarse-grained manner, which causes a long seek distance when multiple virtual machines run concurrently. To overcome this drawback, we propose two novel schemes, called onion and pizza. The onion scheme makes partitions in an interleaved way, which leads to not only reduce a seek distance but also enhance fairness among virtual machines. The pizza scheme goes one step further that makes partitions in a vertical fashion, not a horizontal fashion, so that requests from different virtual machines can be served in a same cylinder. In additional, new sector mapping is devised for efficiency of the two schemes. Real implementation based experiments have shown that our proposal can enhance I/O bandwidth up to 95% with an average of 25%, compared with the traditional scheme.
Phase II study of gemcitabine (G), trastuzumab (H), and pertuzumab (P) for HER2-Positive metastatic breast cancer (MBC) after prior HP- or TDM/P-based therapy. (2016)

611 Background: The combination of taxanes with HP for first line treatment of HER2-positive MBC is associated with improved progression-free (PFS) and overall survival (OS). Previous data demonstrated that treatment per physician’s choice beyond second line leads to median PFS of 3 months. However, the efficacy of continuing HP-based treatment after progression on P-based therapy is unknown. Methods: This is a single arm phase II trial of G with HP. Eligible patients (pts) had HER2-positive (IHC 3+ or FISH > 2.0) MBC with prior HP-based treatment and ≤ 3 prior chemotherapies. Pts received G (1200 mg/m2) on days 1 and 8 of a q 3 week (w) cycle, and H (8 mg/kg load → 6 mg/kg) and P (840 mg load → 420 mg) q3w. The primary endpoint is PFS at 3 months. Secondary endpoints include OS, safety and tolerability. An exploratory endpoint is to compare PFS by RECIST criteria versus 18-F FDG-PET response criteria. Using a Simon optimal 2-stage design, 21 pts will be enrolled in stage 1. If 12/21 (57%) pts are progression free at 3 months, stage 2 will accrue for a total of 45 pts. Results: As of 1-30-16, 17 pts are enrolled; 12 are evaluable at 3 months and 5 have not had 3-month evaluation. At 3 months, 7/12 (58%) are progression free (1 CR, 1 PR, 5 SD); 5 pts progressed. The 3 month-PFS results for all pts will be updated. There are no cardiac or febrile neutropenic events to date. 4 pts required G dose reduction (3 due to grade 3 neutropenia and 1 due to grade 3 vomiting) and the study will be amended to lower initial G dose to 1000 mg/m2. Conclusions: The preliminary 3 month-PFS is 58% in evaluable pts. Updated data for 21 pts in stage 1 will be presented. Clinical trial information: NCT02252887.
Synthesis, characterization and photoreaction of photoreactive side-chain liquid-crystalline copolymers comprising 2-benzoylethoxybiphenyl and 3-methyl-2-butenyloxybiphenyl side groups (1998)

Photo-crosslinkable side-chain liquid-crystalline copolymers comprising 2-benzoylethoxybiphenyl and 3-methyl-2-butenyloxybiphenyl groups were synthesized and characterized. Thermal behavior of the copolymers was determined by differential scanning calorimetry and polarized optical microscopy. All synthesized copolymers were liquid-crystalline having nematic and/or smectic phases, and their mesomorphic transition temperatures hardly varied with composition of the copolymers. Photochemically crosslinked copolymer films obtained by UV-irradiation were insoluble in ordinary organic solvents.
Bringing Reality Back to Virtual Reality - A Collaborative Tool for Multidisciplinary Teams (2020)

We propose a new system combining a physical interface and a virtual environment that can be accessed through VR. Our aim is making collaboration in multidisciplinary teams more productive through the joint effects of immersion and presence through VR and the tactility and intuitiveness of a physical interface. A pilot experiment with 14 participants has been conducted. The study shows potential benefits of the system, such as the simplicity of a physical model promoting engagement, and the in-depth exploratory capabilities of the VR application enabling more solutions to be found.
New Method of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) for Rat Brain Research (2012)

Manganese (Mn(2+))-enhanced MRI (MEMRI) is known to provide insight into functional and anatomical biology. However, this method, which uses Mn(2+) as a MRI-detectable contrast agent, has drawbacks such as the toxicity to cells beyond a certain level of Mn(2+). In this study, we attempt to determine a new method of ICV administration, the optimal concentration of administered Mn(2+) and the optimal MEMRI acquisition time following administration. Male Sprague-Dawley rats were used in the following experimental sessions: (1) intracerebroventricular (ICV) cannula implantation in the region of the cisterna magna, (2) serial dilution of MnCl(2) (20-80 mM), (3) ICV administration of MnCl(2) through the cannula, and (4) T(1)-weighted MRI measurements. We confirmed that cannula implantation in the region of the cisterna magna was a new ICV injection method for the administration of a contrast agent. The optimal concentration for MEMRI was 20/50 mM/µl of MnCl(2). The MEMRI data acquired at different time points indicate that most signal enhancement is maintained during 14-48 h after contrast agent injection, and 24 h was the optimal time to acquire images of the rat brain. The present study offers optimized parameters for contrast agent injection that would be a good basis for studies using MEMRI to research the rat brain.
Enhanced Hot-Carrier Cooling and Ultrafast Spectral Diffusion in Strongly Coupled PbSe Quantum-Dot Solids (2011)

PbSe quantum-dot solids are of great interest for low cost and efficient photodetectors and solar cells. We have prepared PbSe quantum-dot solids with high charge carrier mobilities using layer-by-layer dip-coating with 1,2-ethanediamine as substitute capping ligands. Here we present a time and energy resolved transient absorption spectroscopy study on the kinetics of photogenerated charge carriers, focusing on 0-5 ps after photoexcitation. We compare the observed carrier kinetics to those for quantum dots in dispersion and show that the intraband carrier cooling is significantly faster in quantum-dot solids. In addition we find that carriers diffuse from higher to lower energy sites in the quantum-dot solid within several picoseconds.
Power to Methane technologies through renewable H2 and CO2 from biogas: The case of Sardinia (2021)

A Power-to-Methane system based on a Biological Hydrogen Methanation (BHM) process using the CO 2 produced by a biogas upgrading process and the H 2 produced by an alkaline electrolyser was analysed in this work. The electrolyser can be fed by the electrical energy produced by a dedicated PV plant or supplied by the electrical grid. The analysis of the energy production from the PV plant and the consumption of the electrolyser was carried out on an hourly basis considering different sizes for the PV plant and four different scenarios for the operating time of the electrolyser. Also, a preliminary economic analysis was carried out to estimate the levelized cost of biomethane (LCOBM) and the costs of biomethane transport with a dedicate pipeline and in form of LNG by trucks. Finally, the paper investigated the availability of biomass and biogas in Sardinia that can be converted into biomethane, and the contribution of BHM plants to supply the forecast demand of CH4. The availability of biogas in Sardinia, together with the production of biomethane through BHM systems, can supply up to 44% of the forecast demand of CH 4 .
Inhibited interlayer electron transfer in metal ion linked multilayers on mesoporous metal oxide films (2021)

The incorporation of dye-electron donor motifs on metal oxide surfaces is a common strategy to increase dye regeneration rate, slow recombination, and improve overall dye-sensitized device performance. Here we used zinc ion linked multilayer assembly of a dye (N3) and a cobalt polypyridyl electron donor (Co) on TiO2 as an alternative to traditional covalently linked dye-donor systems. The formation of the TiO2-N3-Zn-Co multilayer was monitored using UV–Vis and ATR-IR and we introduced inductively coupled plasma mass spectrometry as a means of quantifying the surface loading of spectroscopically obscured molecules like Co. Interestingly, and contrary to the original intent, the addition of Co electron donor impeded the dye-sensitized device in nearly every performance metric. Transient absorption measurements indicate that both excited state quenching of N3 by Co and Co to N3+ electron transfer are slower than the intrinsic excited state decay and recombination, respectively. We suggest that the geometric restriction imposed by the metal ion linked architecture sufficiently slows electron transfer such that Co is effectively inert in this assembly. While this bilayer did not improve device performance, these insights may guide new design strategies that will improve performance and/or will be of use in other applications where electron transfer is not desired but say communication of spin and/or magnetic moment is needed.
[Malignant tendency of basophilic liver cells in experimental rat hepatocarcinogenesis]. (2006)

Development of foci of basophilic small cells, with cells containing lipid vacuoles and pale bodies, and invading into the surrounding liver tissues are the changes highly suggestive of an early hepatocellular carcinoma transformation.
Two teosintes made modern maize (2023)

Abstract Despite its global importance as a crop with broad economic, dietary, and cultural importance, the origins of maize and its closest wild relatives remained the topic of vigorous debate for nearly a century. Molecular analyses ultimately concluded that maize was domesticated once from a common ancestor with its closest extant relative, the lowland wild grass Zea mays ssp. parviglumis . But neither the current genetic model nor earlier models based on archaeological data account for the totality of available data, and recent work has highlighted the potential contribution of a second wild relative, the highland Zea mays ssp. mexicana . Here we present a detailed population genetic analysis of the contributions of both wild taxa to modern maize diversity using the largest sample of traditional maize varieties sequenced to date. We show that all modern maize can trace its origin to an ancient admixture event between domesticated ancient maize and Zea mays ssp. mexicana in the highlands of Mexico ca 5300 cal BP, some 4,000 years after domestication began. We show that variation in admixture is a key component of modern maize genetic and phenotypic diversity, both at the level of individual loci and as a factor driving a substantial component of additive genetic variation across a number of agronomic traits. Our results clarify the long-debated origin of modern maize, highlight the potential contributions of crop wild relatives to agronomic improvement, and raise new questions about the anthropogenic mechanisms underlying multiple waves of dispersal throughout the Americas. One-Sentence Summary Our results clarify the long-debated origin of modern maize and highlight the contributions of crop wild relatives to the agronomic improvement of modern varieties.
Hexagonale Antimontartrate Ca[Sb2{(+)-C4H2O6}2]· 2H2O: Kristallzüchtung, elektrooptische und elektrostriktive Eigenschaften (1983)

Article Hexagonale Antimontartrate Ca[Sb2{(+)-C4H2O6}2]· 2H2O: Kristallzüchtung, elektrooptische und elektrostriktive Eigenschaften was published on November 1, 1983 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 163, issue 1-4).
Web page language identification based on URLs (2008)

Given only the URL of a web page, can we identify its language? This is the question that we examine in this paper. Such a language classifier is, for example, useful for crawlers of web search engines, which frequently try to satisfy certain language quotas. To determine the language of uncrawled web pages, they have to download the page, which might be wasteful, if the page is not in the desired language. With URL-based language classifiers these redundant downloads can be avoided. We apply a variety of machine learning algorithms to the language identification task and evaluate their performance in extensive experiments for five languages: English, French, German, Spanish and Italian. Our best methods achieve an F-measure, averaged over all languages, of around .90 for both a random sample of 1,260 web page from a large web crawl and for 25k pages from the ODP directory. For 5k pages of web search engine results we even achieve an F-measure of .96. The achieved recall for these collections is .93, .88 and .95 respectively. Two independent human evaluators performed considerably worse on the task, with an F-measure of .75 and a typical recall of a mere .67. Using only country-code top-level domains, such as .de or .fr yields a good precision, but a typical recall of below .60 and an F-measure of around .68.
Supplementary Table 3 from Invasive Lobular Carcinoma Cell Lines Are Characterized by Unique Estrogen-Mediated Gene Expression Patterns and Altered Tamoxifen Response (2023)

&lt;p&gt;XLSX file - 17K, Expression data from estrogen deprivation studies using PDX HCI-013.&lt;/p&gt;