gebhart/patrepeval huggingface dataset:
The Effect of Prestimulus Alpha Activity on the P300 (1988)

ABSTRACT Trials on which highly discrepant, auditory ‘oddball’ stimuli were presented were sorted into two bins on the basis of prestimulus alpha band RMS magnitude. The trial bins were then separately averaged to produce a ‘high alpha’ auditory ERP (event‐related potential) and a ‘low alpha’ ERP for each subject. Study 1 found that larger amplitude P300s were obtained in the ‘high alpha’ ERP. No effect of alpha was found on the N100. Study 2 employed extra factors of stimulus intensity change (increases and decreases) and alpha measurement period (before and after the ‘oddball’ stimulus). It was found that P300 amplitude enhancement was independent of both stimulus intensity and the amount of alpha poststimulus. The data are discussed in terms of cascaded inhibition from the mesencephalic reticular formation to nucleus reticularis of the thalamus to a thalamo‐cortical system responsible for the generation of both alpha and the P300.
ASPP2: A Gene that Controls Life and Death in Vivo (2006)

The fundamental role of apoptosis in tumor prevention and the important role of p53 in this process are now universally recognized. Recently, several families of p53-binding proteins have been shown to influence p53's decision to direct the cells either into the apoptotic pathway or in cell cycle arrest. Among them, the ASPP family specifically regulate p53-dependent apoptosis. Its member ASPP2 was discovered more than 10 years ago as a binding partner of p53 and its role as a positive regulator of p53 mediated apoptosis has been clearly established in vitro. However, its physiological importance in vivo has just emerged through the generation and characterisation of the ASPP2-deficient mice. We now know that ASPP2 is a haploinsufficient tumor suppressor and an important activator of p53 during mouse development and tumor suppression in vivo. ASPP2 might be a novel target for future cancer therapy.
WiFiProfiler (2006)

While 802.11-based wireless hotspots are proliferating, users often have little recourse when the network does not work or performs poorly for them. They are left trying to manually debug the problem, which can be a frustrating and disruptive process. The users' troubles are compounded by the absence of network administrators or an IT department to turn to in many 802.11 hotspot settings (e.g., cafes, airports, conferences).We present WiFiProfiler, a system in which wireless hosts cooperate to diagnose and possibly resolve network problems in an automated manner, without requiring any infrastructural support. The key observation is that even if a host's wireless link to an access point is not working, the host is often within the range of other wireless nodes and is in a position to communicate with them (a little) peer-to-peer. We leverage this ability to create a shared information plane, which enables wireless hosts to exchange a range of information about their network settings and the health of their network connectivity. By aggregating and correlating such information across multiple wireless hosts, we infer the likely cause of the problem. Our implementation on Windows XP shows that WiFiProfiler is effective in diagnosing a range of problems and imposes a low overhead on the participating hosts.
A four-state EEPROM using floating-gate memory cells (1987)

An electrically erasable programmable read-only memory (EEPROM) is used in a novel way as a four-state memory by charging the floating gate to determined values. The memory cell and the complete programming and readout circuit are described. Retention characteristics are investigated and found to confirm a thermionic emission model. Retention time is estimated to be more than 22 years at 125/spl deg/C. Secondary effects like charge trapping in the oxide are successfully suppressed by a controlled writing procedure. Using such a four-state EEPROM instead of a binary cell, a reduction in chip area of 40% can be expected for a 1-kb memory.
Brief Report: Enrichment of Activated Group 3 Innate Lymphoid Cells in Psoriatic Arthritis Synovial Fluid (2015)

Our findings indicate that PsA SF is enriched for group 3 ILCs that express CCR6 and NKp44, which distinguishes the synovial compartment from RA. The increased IL-17A production by SF ILCs indicates a novel role for ILCs in PsA.
VideoScheme (1993)

Article VideoScheme: a programmable video editing systems for automation and media recognition Share on Authors: James Matthews View Profile , Peter Gloor View Profile , Fillia Makedon View Profile Authors Info & Claims MULTIMEDIA '93: Proceedings of the first ACM international conference on MultimediaSeptember 1993 Pages 419–426https://doi.org/10.1145/166266.168442Published:01 September 1993 11citation475DownloadsMetricsTotal Citations11Total Downloads475Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Objective and subjective outcomes following external dacryocystorhinostomy and inferior tear duct stenting in patients with acquired lacrimal drainage system obstruction (2021)

Abstract The authors have requested that this preprint be removed from Research Square.
Gut-Derived Uremic Toxins in CKD: An Improved Approach for the Evaluation of Serum Indoxyl Sulfate in Clinical Practice (2023)

In the past years, indoxyl sulfate has been strongly implicated in kidney disease progression and contributed to cardiovascular morbidity. Moreover, as a result of its elevated albumin affinity rate, indoxyl sulfate is not adequately cleared by extracorporeal therapies. Within this scenario, although LC-MS/MS represents the conventional approach for IS quantification, it requires dedicated equipment and expert skills and does not allow real-time analysis. In this pilot study, we implemented a fast and simple technology designed to determine serum indoxyl sulfate levels that can be integrated into clinical practice. Indoxyl sulfate was detected at the time of enrollment by Tandem MS from 25 HD patients and 20 healthy volunteers. Next, we used a derivatization reaction to transform the serum indoxyl sulfate into Indigo blue. Thanks to the spectral shift to blue, its quantity was measured by the colorimetric assay at a wavelength of 420-450 nm. The spectrophotometric analysis was able to discriminate the levels of IS between healthy subjects and HD patients corresponding to the LC-MS/MS. In addition, we found a strong linear relationship between indoxyl sulfate levels and Indigo levels between the two methods (Tandem MS and spectrophotometry). This innovative method in the assessment of gut-derived indoxyl sulfate could represent a valid tool for clinicians to monitor CKD progression and dialysis efficacy.
Molière et le monde médical. Warolin (Christian), Molière et le monde médical au XVIIe siècle, Paris, L’Harmattan, 2013 (2014)

Bonnemain Bruno. Molière et le monde médical. Warolin (Christian), Molière et le monde médical au XVIIe siècle, Paris, L’Harmattan, 2013. In: Revue d'histoire de la pharmacie, 101e année, N. 381, 2014. pp. 133-134.
Flexible versus structured support for reasoning: enhancing analytical reasoning through a flexible analytic technique (2020)

Structured analytic techniques (SATs) help the intelligence community reduce flaws in cognition that lead to faulty reasoning. To ascertain whether SATs provide benefits to reasoning we conducted an experiment within a web-based application, comparing three conditions: 1) unaided reasoning, 2) a prototypical order-based SAT and 3) a flexible, process-based SAT that we call TRACE. Our findings suggest that the more flexible SAT generated higher quality reasoning compared to the other conditions. Consequently, techniques and training that support flexible analytical processes rather than those that require a set sequence of steps may be more beneficial to intelligence analysis and complex reasoning.
Human Immunodeficiency Virus DNA is Present in a High Percentage of CD4+ Lymphocytes of Seropositive Individuals (1991)

Human immunodeficiency virus type 1 (HIV-1) infects predominantly CD4+ cells in human peripheral blood and infection is associated with CD4+ lymphocyte dysfunction in patients with AIDS. To determine the frequency of HIV-1 infection in CD4+ lymphocytes in vivo, peripheral blood CD4+ lymphocytes were isolated by fluorescence-activated cell sorting from HIV-1-infected persons with clinical disease ranging from asymptomatic to AIDS. Using standard and booster polymerase chain reaction analyses, study patients with AIDS and AIDS-related complex (ARC) were found to harbor the HIV-1 genome in at least 10% of CD4+ lymphocytes, and approximately 10-fold less infected cells were found in those with asymptomatic infection. In addition, the peripheral blood mononuclear cells from patients with ARC frequently contained a higher absolute number of HIV-1-infected CD4+ lymphocytes than those with AIDS or asymptomatic infection. It is likely that this high level of infection of CD4+ lymphocytes is the primary cause for the progressive immunologic deficiency observed in patients infected with HIV-1.
Monitoring for DNA damage of humans occupationally exposed to methyl bromide. (2002)

Within the detection power of this limited study, no significant evidence of induction of DNA damage in blood leukocyte DNA by MeBr was found.
Analysis of Running-Related Injuries: The Vienna Study (2020)

Running-related injuries are multifactorial associated with a combination of variables including personal data, training load, anatomic malalignments, and injury history. They can furthermore result from a lack of experience/training as well as from overuse. Suffering a specific RRI of high risk could be defined based on individual predispositions and help to induce appropriate training balance.
POLYGENIC HYPERLIPIDEMIA AND CORONARY ARTERY DISEASE RISK (2017)

Abstract Background Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). Monogenic familial hypercholesterolemia associates with higher increase in CAD risk than expected from a single LDL-C measurement, likely due to lifelong cumulative exposure to high LDL-C. It remains unclear to what extent a high polygenic load of LDL-C or TG-increasing variants associates with increased CAD risk. Methods and Results We derived polygenic risk scores (PRS) with ∼6M variants for LDL-C and TG with weights from a UK biobank-based genome-wide association study with ∼500K samples. We evaluated the impact of polygenic hypercholesterolemia and hypertriglyceridemia to lipid levels in 27 039 individuals from the FINRISK cohort, and to CAD risk in 135 300 individuals (13 695 CAD cases) from the FinnGen project. In FINRISK, LDL-C ranged from 2.83 (95% CI 2.79-2.89) to 3.80 (3.72-3.88) and TG from 0.99 (0.95-1.01) to 1.52 (1.48-1.58) mmol/l between the lowest and highest 5% of the respective PRS distributions. The corresponding CAD prevalences ranged from 8.2% to 12.7% for the LDL-C PRS and from 8.2% to 12.1% for the TG PRS in FinnGen. Furthermore, CAD risk was 1.36-fold higher (OR, 95% CI 1.24-1.49) for the LDL-C PRS and 1.31-fold higher (1.20-1.44) for the TG PRS for those with the PRS >95th percentile vs those without. These estimates were only slightly attenuated when adjusting for a CAD PRS (OR 1.26 [95% CI 1.15-1.39] for LDL-C and 1.21 [1.10-1.32] for TG PRS). Conclusions The CAD risk associated with a high polygenic load for lipid-increasing variants was proportional to their impact on lipid levels and mostly independent of a CAD PRS. In contrast with a PRS for CAD, the lipid PRSs point to known and directly modifiable risk factors providing more direct guidance for clinical translation.
Correlated Wavefunction Monte Carlo Studies of Excitations in the Quantum Hall Liquids (1994)

Various excitations in the quantum Hall liquid at different Landau level filling factors are studied using a variational quantum Monte Carlo approach. Quantities calculated include spin-flip energies and dispersion relations for the collective modes (the magnetorotons and magnetoplasmons). The present approach goes beyond the lowest-Landau-level and single-mode approximations commonly used in previous studies. The inclusion of Landau-level mixing along with finite-thickness and donor effects satisfactorily explains values for the {nu} = 1 spin-flip energy that are found in recent photoluminescence experiments on {delta}-doped samples. In the case of the magnetorotons at {nu} = 1/3, the authors show that multiple-mode effects can change the excitation energies significantly, especially for high r{sub s} samples (by nearly 50% at r{sub s} = 20).
Calculation of Iron Losses in Electrical Machines using the Preisach Model (1996)

EMF'96
Tailoring mechanical response through coronal layer overlap in tethered micelle hydrogel networks (2015)

Tethered micelle hydrogel networks based on the solution assembly of amphiphilic ABA-type block copolymers are prevalent throughout the hydrogel literature. However, the mechanical response of such systems is often determined largely by the integrity of the micellar core produced during solution assembly, not by the elements of the network structure upon which it is based. Using a solvent-free fabrication method based on the melt-state self-assembly of sphere-forming polystyrene-b-poly(ethylene oxide) (SO) diblock and SOS triblock copolymers blends, we have been able to produce tethered micelle hydrogel networks with fully vitrified cores that enable the elements of the network structure to determine the mechanical response. Here, we explore the impact of using PEO midblocks of different lengths within the SOS tethers, in an effort to elucidate the role played by water content, tether concentration, and tether length in mechanical property determination. In doing so, we were able to establish coronal layer overlap as the primary contributing factor in regulating the dynamic elastic moduli exhibited by tethered micelle systems. Variation of either tether concentration or tether length could be used to tune the degree of coronal layer overlap, enabling direct and accurate control over hydrogel mechanical response. While such control is likely a unique feature of the melt-state fabrication approach applied here, the conclusions with respect to the role of coronal layer overlap and tether (bridging) concentration in determining the mechanical potential of the network should be applicable to all ABA-type tethered micelle systems, regardless of fabrication methodology.
Antibiotic-loaded bone cement and its widespread use: is it justified? (2015)

Along with a steady rise in the volume of joint prostheses implanted every year worldwide, there has been a rise in revision after total hip arthroplasty (THA) and total knee arthroplasty. Among the main reason for THA revision, infection accounts for 12.0–25.2 %. Nowadays the use of antibiotic-loaded bone cement (ALC) with the aim to reduce periprosthetic joint infection (PJI) has greatly increased. The use of ALC in primary prosthesis fixation is still debated. So in order to be able to provide a reasonable and scientific answer to this question one should first analyze data from scientific literature. In terms of prophylaxis, it was demonstrated in many investigations that the combined use of systemic antibiotic and ALC in THA was producing the lowest risk of revision due to infection. The release of antibiotic from ALC has a well known kinetics, with a peak release during the first days followed by a long tail of lower release. The choice of adding an Aminoglycoside (Gentamicin) was based on release studies which demonstrated that among antibiot­ics Gentamicin was showing the best elution performances from the bone cement, the most extended spectrum of activity and no negative effects on mechanical performances. As regards possible problems associated with the presence of antibiotic in bone cement the following should be considered: systemic toxicity, hypersensitiv­ity reaction, mechanical hazards, bacterial resistance hazards and cost rising. In conclusion, the use of ALC must be considered as a support strategy in prevention and not the solution of infections; in primary implants, ALC is justified only in high risk patients; it is recommended for revisions; the perfect antibiotic in ALC does not exist; avoid using Vancomycin as first step; ALC is successful only if associated with systemic antibiotics.
Non-Linear Model Formulation for the Static and Dynamic Analyses of Front Suspensions (1977)

&lt;div class="htmlview paragraph"&gt;A three degree-of-freedom mathematical model formulation for a double-wishbone front suspension is presented which treats the effects of the tire vertical stiffness, the fore-and-aft bushing compliance in the lower arm, the compliance in a steering linkage and the inertia of the suspension links. The model equations are derived retaining all non-linearities associated with large changes in the geometric configuration of the suspension system and are solved within a digital computer program which computes the suspension force and displacement response to prescribed ground terrain inputs at the tire patch. Results obtained with the computer model are presented and compared with test measurements.&lt;/div&gt;
Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP (2014)

Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal hippocampal dendritic spine formation and synaptogenesis. Although leptin has been shown to induce synaptogenesis in the hypothalamus, its effects on hippocampal synaptogenesis and the mechanism(s) involved are not well understood. Here we show that leptin receptors (LepRs) are critical for hippocampal dendritic spine formation in vivo because db/db mice lacking the long form of the leptin receptor (LepRb) have reduced spine density on CA1 and CA3 neurons. Leptin promotes the formation of mature spines and functional glutamate synapses on hippocampal pyramidal neurons in both dissociated and slice cultures. These effects are blocked by short hairpin RNAs specifically targeting the LepRb and are absent in cultures from db/db mice. Activation of the LepR leads to cAMP response element-binding protein (CREB) phosphorylation and initiation of CREB-dependent transcription via the MAPK kinase/Erk pathway. Furthermore, both Mek/Erk and CREB activation are required for leptin-induced synaptogenesis. Leptin also increases expression of microRNA-132 (miR132), a well-known CREB target, which is also required for leptin-induced synaptogenesis. Last, leptin suppresses the expression of p250GAP, a miR132 target, and this suppression is obligatory for leptin's effects as is the downstream target of p250GAP, Rac1. LepRs appear to be critical in vivo as db/db mice have lowered hippocampal miR132 levels and elevated p250GAP expression. In conclusion, we identify a novel signaling pathway by which leptin increases synaptogenesis through inducing CREB transcription and increasing microRNA-mediated suppression of p250GAP activity, thus removing a known inhibitor of Rac1-stimulated synaptogenesis.
Abstract: W18.00010 : An Optical Biosensing Platform Using Reprecipitated Polyaniline Microparticles (2009)

A great deal of effort remains focused on the goal of developing a continuous \textit{in vivo} glucose monitoring system for patients with \textit{diabetes mellitus.} We report a proof-of-concept study on a reagentless optical biosensing platform that circumvents the problems usually associated with direct glucose detection by utilizing the UV-VIS absorption properties of polyaniline, a biocompatible polymer. When the enzyme glucose oxidase is entrapped within reprecipitated polyaniline microparticles, a glucose molecule readily donates two protons and two electrons to the polyaniline, reversibly altering the polymer's oxidation state. The resultant change can be monitored by measuring the absorption at wavelengths that fall within the ``optical window'' for skin. The micro-structured morphology also insures a high surface-area to volume ratio. Data from \textit{in vitro} prototype devices indicate that in the low enzyme-loading regime, the response can be fit to the Michaelis-Menten model for enzyme kinetics, but at higher enzyme loading, diffusion effects dominate. As a biosensing platform, the system also has the potential to be adapted to detect other biologically relevant analytes, including cholesterol and ethanol.
Neutropenia in pediatric solid organ transplant (2022)

Neutropenia is generally defined as an absolute neutrophil count in the circulation of less than 1500/mm<sup>3</sup> and occurs in up to 25%-30% of pediatric solid organ transplant recipients (SOT) within the first year after transplantation. In the SOT population, neutropenia is most often a result of drug-induced bone marrow suppression but can also be secondary to viral infection, nutritional deficiencies, lymphoproliferative infiltrate, and inherited causes. Outcomes for patients with neutropenia vary by degree of neutropenia and type of solid organ transplant. Management of neutropenia should begin by addressing the underlying cause, including reducing or removing medications when appropriate, treating infections, and addressing nutrient deficiencies; however, consultation with an experienced pediatric hematologist and use of granulocyte colony-stimulating factor (G-CSF) may be helpful in some cases. Overall, data on clinical outcomes for G-CSF use remain limited, but observational studies may support its use in patients with infections or severe neutropenia.
The Calculation of Roll Force and Torque in Hot Rolling Mills (1954)

Equations are derived for the normal roll pressure, specific roll load and torque in hot rolling mills, using the condition for plastic deformation in rolling derived by Orowan, together with von Kármán's equation of equilibrium. Although applying strictly to the rolling of ideal plastic-rigid materials, these equations may be applied to the rolling of materials which strain-harden by using a mean value of the yield stress in the pass. The equations have been checked against measurements made when rolling pure lead at room temperatures, and against the results of the experiments on steel at elevated temperatures carried out at Holfors. There is close agreement between the calculated and measured roll loads, but the roll torque is over-estimated slightly by the theory, above reductions of about 30 per cent in thickness.
Zinc halide hydrocracking process for distillate fuels from coal. Quarterly technical progress report, February 1--April 30, 1977. [4 refs] (1977)

The bench-scale continuous hydrocracker has completed the original program of studies on Colstrip coal covering temperature, pressure, and residence time. A few additional runs will extend the matrix to more severe conditions. A reaction rate model will be developed. The gasoline produced in the above program meets specifications and has a research octane number of about 91. Complete balances on a continuous run confirm that 100 x 200/sup 0/C distillate could be recycled as a coal vehicle with only 1 to 2% conversion to nongasoline per pass. Continuous tests of secondary recovery of zinc from the waste coal ash confirm that economic recovery of zinc chloride will be obtained. Construction of the 100 lb/hr Process Development Unit remains on schedule. Materials testing continues and is reported herein.