gebhart/patrepeval huggingface dataset:
Proton MASS-NMR: a new tool to study thermoreversible transition in hydrogels (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton MASS-NMR: a new tool to study thermoreversible transition in hydrogelsM. V. Badiger, P. R. Rajamohanan, M. G. Kulkarni, S. Ganapathy, and R. A. MashelkarCite this: Macromolecules 1991, 24, 1, 106–111Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://doi.org/10.1021/ma00001a017RIGHTS & PERMISSIONSArticle Views229Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (583 KB) Get e-Alerts Get e-Alerts
Acyl lipid metabolism in the oleaginous yeastRhodotorula gracilis (CBS 3043) (1989)

Abstract The effects of culture conditions on acyl lipid metabolism in the oleaginous yeast Rhodotorula gracilis (CBS 3043) have been investigated. Growth of R. gracilis under conditions of nitrogen‐limitation resulted in the accumulation of large quantities of triacylglycerols. Thin layer and gas chromatographic analysis of total lipid extracts revealed that the majority of this storage lipid was produced by stationary‐phase cells. In contrast, no such increase in triacylglycerol biosynthesis could be detected in carbon‐limited cells. Freeze‐fracture electron microscopy evidence supported these findings. Growth medium composition was found to have little effect on the relative abundance of the primary phospholipid classes present in R. gracilis . The acyl compositions of triacylglycerols were similarly unchanged by alterations in the composition of the growth medium. In contrast, the degree of unsaturation exhibited by the phospholipid fractions appeared to be particularly sensitive to this external parameter. Acyl quality of triacylglycerol pools extracted from nitrogen‐limited cells were observed to become increasingly saturated as cultures increased in age. Growth of nitrogen‐limited cells at a lower growth temperature was observed to have little effect on triacylglycerol accumulation. However, both triacylglycerol and phospholipid fractions extracted from these cultures were found to contain increased proportions of the polyunsaturated fatty acid, α‐linolenate.
Seminal vesicle autoantigen, a novel phospholipid-binding protein secreted from luminal epithelium of mouse seminal vesicle, exhibits the ability to suppress mouse sperm motility (1999)

Seminal vesicle autoantigen (SVA) is a 19 kDa glycoprotein purified from mouse seminal vesicle secretion. It was quantified to be 0.9% (w/v) in the seminal vesicle fluid. We examined its distribution in the accessory sexual gland, characterized its binding sites on the sperm surface and assessed its effect on sperm motility. It was immunolocalized on the epithelium of the primary and secondary folds in the tissue. Mouse spermatozoa collected from caudal epididymis were devoid of SVA. A cytochemical study illustrated the presence of SVA-binding region on the entire cells. The cytochemical staining intensity for the binding of SVA to spermatozoa remained even when the cells were pretreated with protease digestion, acid or heat at 100 degrees C for 10 min. Moreover, the SVA-sperm binding could be inhibited by the dispersed sperm lipid. The specificity of interaction between (125)I-SVA and phospholipids was studied by TLC overlay techniques. The radiolabelled protein showed strong binding to purified phosphatidylcholine and phosphatidylserine and weak binding to purified sphingomyelin, lysophosphatidylcholine and phosphatidylethanolamine, but did not interact with phosphatidic acid, lysophosphatidic acid or phosphatidylinositol. Among the lipids extracted from spermatozoa, SVA showed strong binding to phosphatidylcholine and weak binding to sphingomyelin and neutral lipids. The assay for SVA-sperm binding with (125)I-SVA determined the IC(50) as being (3.89+/-0.65)x10(-5) M(-1), which is compatible with an apparent dissociation constant of (9.10+/-0.02)x10(-5) M(-1) estimated by fitting the data of phosphatidylcholine-perturbed SVA fluorescence to a modified Scatchard plot. SVA showed an ability to suppress sperm motility. The average path velocity, straight-line velocity and curvilinear velocity of sperm were not detectable by computer-assisted sperm assay after incubation of the cells in the presence of 0.3% SVA at 37 degrees C for more than 40 min.
The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET -Amplified Cancer (2014)

Activation of the MET/HGF pathway is common in human cancer and is thought to promote tumor initiation, metastasis, angiogenesis, and resistance to diverse therapies. We report here the pharmacologic characterization of the triazolopyridazine derivative SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. SAR125844 displayed nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and the M1250T and Y1235D mutants. Broad biochemical profiling revealed that SAR125844 was highly selective for MET kinase. SAR125844 inhibits MET autophosphorylation in cell-based assays in the nanomolar range, and promotes low nanomolar proapoptotic and antiproliferative activities selectively in cell lines with MET gene amplification or pathway addiction. In two MET-amplified human gastric tumor xenograft models, SNU-5 and Hs 746T, intravenous treatment with SAR125844 leads to potent, dose- and time-dependent inhibition of the MET kinase and to significant impact on downstream PI3K/AKT and RAS/MAPK pathways. Long duration of MET kinase inhibition up to 7 days was achieved with a nanosuspension formulation of SAR125844. Daily or every-2-days intravenous treatment of SAR125844 promoted a dose-dependent tumor regression in MET-amplified human gastric cancer models at tolerated doses without treatment-related body weight loss. Our data demonstrated that SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile, supporting its clinical development in patients with MET-amplified and MET pathway-addicted tumors.
[Three-dimensional fusion imaging of lymphoscintigraphy and MDCT for sentinel node biopsy in breast cancer]. (2003)

The purpose of this study was to evaluate the clinical usefulness of three-dimensional (3D) fusion imaging of lymphoscintigraphy with 99mTc phytate and MDCT (four-slice CT) for sentinel node biopsy in breast cancer. Volume-rendering images generated by MDCT were fused with lymphoscintigrams on a personal computer. The subjects were 7 patients with clinically negative nodes. In all patients, sentinel nodes were identified by lymphoscintigraphy, and the anatomical locations of sentinel nodes were clearly demonstrated by 3D-fusion imaging. 3D-fusion imaging of lymphoscintigraphy and MDCT is expected to be a promising method for sentinel node biopsy in breast cancer.
Metcalfe, Alan. Canada Learns to Play: The Emergence of Organized Sport, 1807–1914. (1989)

Metcalfe, Alan. Canada Learns to Play: The Emergence of Organized Sport, 1807–1914. Toronto: McClelland and Stewart, 1987. Pp. 243. Illustrations. $15.95 (paper). An article from journal Urban History Review / Revue d'histoire urbaine (Volume 17, Number 3, February 1989, pp. 143-229), on Érudit.
Chemical Reactor Theory: an Introduction (1965)

Preface 1. Introduction: reactor types 2. Chemical kinetics 3. Tubular reactors 4. Continuous stirred tank reactors 5. Residence-time distributions, mixing and dispersion 6. Chemical factors affecting the choice of reactor 7. Packed-bed catalytic reactors: mass- and heat-transfer effects 8. Multiphase reactors 9. Some further temperature effects in reactors 10. Optimization: concluding comments Index.
SignalViewer: analyzing microarray images (2003)

Microarray technology is now routinely used to monitor genome-wide expression profiles. However, current microarray imaging and analysis packages typically require manual intervention and assumptions on alignments. Unfortunately, limitations and assumptions are typically undisclosed and methods are not published. To facilitate exploration of image data, we developed SignalViewer. This paper presents a description of the application.
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System (2023)

Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
The application of image quality measurements for digital angiography (2005)

The image quality (IQ) evaluation of a charge-coupled device (CCD)-based digital angiography system was assessed with respect to modulation transfer function and noise power spectrum. These values were used to calculate the system's frequency-dependent detective quantum efficiency (DQE). The X-ray image detector was an image intensifier (II) lens coupled to a CCD camera. Two measurement setups were used. Setup A is standard IQ assessment, while Setup B more closely represented clinical conditions (polymethyl methacrylate (PMMA) of varying thickness placed between the X-ray tube and II, with test object positioned between PMMA slices 30 cm from the II). Exposure parameters varied according to automatic brightness control settings. Setup B included X-ray radiation scattered by the patient-PMMA. A clinical DQE, describing the transmission of the input signal-to-noise ratio associated with both primary and secondary X-ray spectra, was defined.
A continuous review inventory model with a time discount (1998)

This paper presents a continuous review inventory model with a lost sales assumption. The model is unique due to the inclusion of a time discount. Whenever the supplier faces the likelihood of being out of stock, he may issue a discount to motivate customers to accept delayed deliveries and thus avoid the occurrence of lost sales. We propose a control policy with four parameters R <sub>1</sub>, Q, R <sub>2</sub> and T where R <sub>1</sub> and Q are the normal reorder point and quantity, respectively and R <sub>2</sub> and T are the triggers for this time discount. During each replenishment cycle, if the on-hand inventory drops to R2 at or before T after the reorder time epoch, the time discount will be granted. A derivation as well as a solution approach for the total cost function are provided. Based on computational results, such a system with a time discount is superior to that without a time discount in terms of minimizing the total system cost. Finally, we compare the performance of the time discount and the emergency ordering approaches.
Optical Probe in MgZnO Alloys with Varied Mg Ratios by Metalorganic Chemical Vapor Deposition (2013)

We present a study on five Mg x Zn 1-x O samples with varied x (x = 0, 0.01, 0.06, 0.10 and 0.14), grown on sapphire substrate by Metalorganic Chemical Vapor Deposition (MOCVD). Combined photoluminescence (PL) and Raman scattering studies were carried out over a temperature range of 80K-470K, under the excitation of UV 325 nm. Temperature dependence of the PL for MgZnO with x = 0, 0.01 and 0.06 are shown. The resonance Raman longitudinal optical (LO) multiple modes are exhibited for MgZnO with x = 0.06, 0.10 and 0.14 over all temperature range. Raman shifts exhibit a quadratic dependence on temperature in the measured temperature range. These dependences can be calculated, based upon a model involving three-and four-phonon coupling. We attribute both the thermal expansion and four-phonon terms in the four-phonon anharmonic processes to describe the change of Raman shift with temperature.
An access control framework for business processes for web services (2003)

Business Processes for Web Services are the new paradigm for the lightweight integration of business from different enterprises.Whereas the security and access control policies for basic web services and distributed systems are well studied and almost standardized, there is not yet a comprehensive proposal for an access control architecture for business processes. The major issue is that a business process describe complex services that cross organizational boundaries and are provided by entities that see each other as just partners and nothing else.This calls for a number of differences with traditional aspects of access control architectures such as• credential vs classical user-based access control,• interactive and partner-based vs one-server-gathers-all requests of credentials from clients,• controlled disclosure of information vs all-or-nothing access control decisions,• abducing missing credentials for fulfilling requests vs deducing entailment of valid requests from credentials in formal models,• "source-code" authorization processes vs data describing policies for communicating policies or for orchestrating the work of authorization servers.Looking at the access control field we find good approximation of most components but not their synthesis into one access control architecture for business processes for web services, which is the contribution of this paper.
PV Absorber Layered Materials Formation Using Potential Pulse Atomic Layer Deposition (PP-ALD), (2017)

Thin film photovoltaic solar cells are a promising avenue for solar technology. However, they currently are not as cost effective as fossil fuels. Several absorber layer materials have been formed using various methods in the past. CuIn (1-x) Ga x Se 2 (CIGS) is a promising material due to its tunable direct bandgap, allowing thin films to be used in photovoltaic devices. Previous studies of CIGS done by the author’s group investigated thin film deposition using electrochemical atomic layer deposition (E-ALD). Potential Pulse Atomic Layer Deposition (PP-ALD) is an electrochemical method of atomic layer deposition that relies on alternating cathodic and anodic potential pulses. Cathodic potential pulses long enough to form fractions of a monolayer are used. This is followed by an anodic potential which makes use of the underpotential deposition (UPD) phenomenon to strip away excess bulk, allowing stoichiometric deposits. Because short pulses are used, there is not enough time for excess elemental layers to be formed. PP-ALD is also a one solution co-electrodeposition technique. This differs from the previous E-ALD, which required multiple solution switching, allowing for PP-ALD to have shorter deposition cycles, saving solution and time. Initial results for the formation of In 2 Se 3 and other components of the CIGS compound will be discussed.
Special issue on video communications, processing, and understanding for third generation surveillance systems (2001)

This Special Issue focuses on the problems of last generation surveillance systems and highlights solutions to these problems that are based on a stronger integration of techniques for multisensor data acquisition, communications and processing. This integration is possible by the common "full digital" perspective on which the techniques used by new systems are based. Next generation surveillance systems can be considered as an emerging application field requiring multidisciplinary expertise going from signal and image processing, to communications and computer vision.
Probabilistic modeling of microelectromechanical systems (MEMS) (2002)

Micro-Electro-Mechanical Systems (MEMS) are a fast-developing technology that have a potential to permeate most engineering and medical applications. For this technology to continue expanding, issues regarding the cost of manufacturing and reliability of the devices have to be addressed. To improve the reliability, probabilistic design methodologies are potent in both the modeling and testing of high-performance MEMS. The benefit of probabilistic design approaches is a more rational basis for making design decisions that balance component or system efficiency with reliability or safety. Probabilistic methods are used to assess uncertainties involved in the manufacturing of MEMS devices. Probabilistic methods guide the design of these devices to achieve reliable design in a most efficient way. The objectives of the research work were to formulate and analyze probabilistic failure criteria on a simplified capacitive accelerometer mode. In this respect, comprehensive probabilistic and deterministic analysis was carried out for the selected model. The scope of work is threefold. First, two probabilistic failure criteria will be investigated on the capacitive structure, namely probabilistic clearance failure criterion and probabilistic fracture toughness failure criterion. Second, four kinds of probabilistic analyses for characterization of MEMS will be used: probability of failure, sensitivity analysis, safety index, and probability-based design. Third, three kinds of finite element analyses, namely static, modal and spectral analysis, will be used to see the deterministic response and will be compared with probabilistic result
The fragile X premutation in carriers and its effect on mutation size in offspring. (1995)

The pattern of inheritance in the fragile X (fra(X)) mutation follows a multistage intergenerational process in which the premutation evolves into the full mutation and the characteristic phenotype of the fra(X) syndrome after passing through oogenesis or a postzygotic event. Findings from our multicenter study confirm a strong direct relationship between fra(X) premutation size in the mother and probability of a full mutation in offspring with the mutation. Remarkably, the best-fitting equations are nonlinear asymptotic functions. The close approximation to both the logistic model and Gompertz suggests a process of accumulation of errors in DNA synthesis, as has been proposed previously. We also note that a larger-than-expected number of daughters of transmitting males have premutations that are smaller than their fathers', and that proportion is significantly higher than the proportion of daughters whose premutations are smaller than their mothers'. Intergenerational decreases in premutation size have been reported in other trinucleotide-repeat disorders and also appear to be parent-of-origin specific. Thus, while intergenerational expansion to the full mutation in fra(X) may manifest a postzygotic event, decreases in mutation size may occur during or prior to meiosis.
A Dual Pressure Linear Ion Trap Orbitrap Instrument with Very High Sequencing Speed (2009)

Since its introduction a few years ago, the linear ion trap Orbitrap (LTQ Orbitrap) instrument has become a powerful tool in proteomics research. For high resolution mass spectrometry measurements ions are accumulated in the linear ion trap and passed on to the Orbitrap analyzer. Simultaneously with acquisition of this signal, the major peaks are isolated in turn, fragmented and recorded at high sensitivity in the linear ion trap, combining the strengths of both mass analyzer technologies. Here we describe a next generation LTQ Orbitrap system termed Velos, with significantly increased sensitivity and scan speed. This is achieved by a vacuum interface using a stacked ring radio frequency ion guide with 10-fold higher transfer efficiency in MS/MS mode and 3-5-fold in full scan spectra, by a dual pressure ion trap configuration, and by reduction of overhead times between scans. The first ion trap efficiently captures and fragments ions at relatively high pressure whereas the second ion trap realizes extremely fast scan speeds at reduced pressure. Ion injection times for MS/MS are predicted from full scans instead of performing automatic gain control scans. Together these improvements routinely enable acquisition of up to ten fragmentation spectra per second. Furthermore, an improved higher-energy collisional dissociation cell with increased ion extraction capabilities was implemented. Higher-collision energy dissociation with high mass accuracy Orbitrap readout is as sensitive as ion trap MS/MS scans in the previous generation of the instrument.
Human macrophage colony-stimulating factor is expressed at and shed from the cell surface (1994)

Surface membrane-associated growth factors are being recognized as important for developmental processes, including cell assembly, differentiation, and growth. To investigate the role of membrane-bound macrophage colony-stimulating factor (M-CSF) in myelopoiesis, and whether this factor is released from the cell surface in association with shed membrane-derived vesicles, COS-1 cells were transfected with cDNAs for M-CSF-tau (containing the transmembrane domain) or a soluble mutant form of the molecule lacking the transmembrane domain ([s]M-CSF-alpha). COS-1 cells transfected with either cDNA released activity into the spent culture medium. Conditioned medium was separated by centrifugation into supernatants and pellets were found to contain plasma membrane-derived vesicles by transmission electron microscopy. When medium fractions were assayed in marrow cultures, activity was localized to shed plasma membrane-derived vesicles in medium conditioned by cells transfected with cDNA for M-CSF-tau and in the vesicle-free supernatants of medium conditioned by cells transfected with cDNA for [s]M-CSF-alpha. In addition, nuclear, mitochondrial, and plasma membrane subfractions of stably transfected cells were prepared and assayed for activity. Concentration-dependent stimulation of macrophage colony formation was observed with purified plasma membranes (but not nuclear or cytosolic proteins) from cells transfected with cDNA for M-CSF-tau. By contrast, membranes from untransfected cells and cells transfected with cDNA for [s]M-CSF-alpha or control DNA expressed no activity. Together, the data indicate that human M-CSF is expressed at the cell surface and exfoliated in association with surface membrane-derived vesicles.
Predictors of response to opicinumab in acute optic neuritis (2018)

Age was the strongest prespecified baseline characteristic associated with a treatment effect of opicinumab. A strong association between VEP latency recovery at week 24 and early RGCL/IPL preservation was observed.
Spontaneous Intracranial Hypotension‐Hypovolemia Associated With Tacrolimus (2010)

There is little precedent for a medication-induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus (FK506). A literature review for potential causes of a tacrolimus-induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use.