gebhart/patrepeval huggingface dataset:
Full-Scale Field Test on Estimation of Countermeasure for Liquefaction by Densification Method for Runway Pavement (2010)

The role of an airport during and after a great earthquake is important because of its helpful function for emergency medical services and special activities of the transport of relief supplies to the disaster areas. In this study, the authors conducted a full-scale field experiment on liquefaction phenomena induced artificially by controlled-blast technique in the experimental site at the Ishikari Bay New Port in Hokkaido Island, in order to investigate the influence of a great earthquake on the airport's function in Japan. This experiment especially focused on the assessment of the performance of runway pavement and the effect of densification method as countermeasure for liquefaction with a cost-reduction design. This study concludes that densification method examined with cost-reduction design in this experiment keeps its effectiveness based on results of measurements of liquefaction behavior of liquefied layer and runway pavement, ground investigations after liquefaction and liquefaction-induced residual deformation analysis.
Component Change List Prediction for BIM-Based Clash Resolution from a Graph Perspective (2021)

Information technologies, such as building information modeling (BIM), significantly improve the clash detection process, but the clash resolution process is still time consuming. Although some studies have devoted attention to this field, they rarely discuss the dependency relations between clashes, which impact clash resolution in practice. This paper proposes to adopt graph theory to capture clash dependency and harnesses the information embedded in BIM models. This provides decision support for clash resolution, specifically focusing on automatically generating a component change list to minimize potential change impacts. This paper maps this situation as a minimum-weight vertex cover problem and discusses how to use component attributes to calculate vertex weights for approximating component change impact. Then, a branch and bound algorithm is designed to search for an optimal component change list. The paper tests the framework in two construction projects, and the results show the efficiency of the designed algorithm. The validity of the proposed method is further supported by comparing the list generated by the proposed method with actual project solutions.
Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case–control study (2012)

The lower levels of antibodies found in children with SM compared to children with UM were not attributable to lower exposure to P. falciparum in the SM group. IgM against P. falciparum and specific IgG against a rosetting PfEMP1 domain may play a role in the control of SM, whereas an imbalanced pro-inflammatory cytokine response may exacerbate the severity of infection. A high overlap in symptoms together with a limited sample size of different SM clinical groups reduced the power to identify immunological correlates for particular forms of SM.
Ruthenium nanocrystals as cathode catalysts for lithium-oxygen batteries with a superior performance (2013)

The key factor to improve the electrochemical performance of Li-O₂ batteries is to find effective cathode catalysts to promote the oxygen reduction and oxygen evolution reactions. Herein, we report the synthesis of an effective cathode catalyst of ruthenium nanocrystals supported on carbon black substrate by a surfactant assisting method. The as-prepared ruthenium nanocrystals exhibited an excellent catalytic activity as cathodes in Li-O₂ batteries with a high reversible capacity of about 9,800 mAh g⁻¹, a low charge-discharge over-potential (about 0.37 V), and an outstanding cycle performance up to 150 cycles (with a curtaining capacity of 1,000 mAh g⁻¹). The electrochemical testing shows that ruthenium nanocrystals can significantly reduce the charge potential comparing to carbon black catalysts, which demonstrated that ruthenium based nanomaterials could be effective cathode catalysts for high performance lithium- O₂ batteries.
A combination of stainless steel coil and compressed Ivalon: a new technique for embolization of large arteries and arteriovenous fistulas. (1981)

The abdominal aortas in eight dogs were successfully occluded with a combination of stainless steel coils and compressed Ivalon (polyvinyl alcohol). There was no evidence of recanalization up to six months later. This combination is useful for the embolization of large arteries and arteriovenous fistulas.
1169. Derivation And Validation of an International Clinical Prognostication Model for 28-day Sepsis Mortality. (2022)

Abstract Background Survival prediction models have largely been derived and validated only in high-resource Western countries or in single center studies. We sought to create a prediction model for 28-day mortality using laboratory and physiologic parameters from 3 international sepsis cohorts and externally validated the model. Methods During 2014 to 2021, adult hospitalized patients with suspected infection were enrolled in Durham, United States (N=180) and those with suspected infection and ≥2 SIRS (Systemic Inflammatory Response Syndrome) criteria in Takeo, Cambodia (N=200), and Kumasi, Ghana (N=187). Twenty-five clinical laboratory and physiologic parameters were candidate covariates and sepsis screening scores included as comparators. First, bivariate Cox regression models were performed to determine risk of individual parameters. Then, a 10-fold cross-validated forward stepwise model selection technique was used to eliminate nonsignificant variables using a p-value &amp;lt; 0.10 and the cross-validated C-statistic was estimated. Lastly, this model was applied to an external cohort of hospitalized adults with suspected infection and ≥2 SIRS in Fort Portal, Uganda (N=331 with 9.3% 28-day mortality). Results Among 567 participants, overall mortality was 16.4% at 28-days. Mortality rate highest in Ghana (31.0%), followed by Cambodia (11.0%) and the United States (7.2%). Bivariate analyses identified hypernatremia ( &amp;gt;145 mEq/L) being associated with the highest risk of death (hazard ratio: 7.42; 95% CI: 3.65 to 15.10; Figure 1). On multivariable analysis, a 28-day mortality model including mean arterial pressure, Glasgow Coma score, blood sodium, lactate, and blood urea nitrogen (Table 1) resulted in a 10-fold cross-validated C-statistic of 0.80 (95% CI: 0.61 to 0.88). This model predicted mortality accurately in the validation cohort with a C-statistic of 0.74 (95%CI: 0.69 to 0.79). Figure 1.Forest plot for bivariate analyses for one month survival across United States, Cambodia, and Ghana cohorts. Conclusion Hypotension, altered mental status, serum sodium, serum BUN, and plasma lactate accurately identified risk of death by 28-days among those with suspected sepsis in 3 international derivation cohorts and in a validation cohort in Uganda. Our findings emphasize the importance of clinical laboratory results for sepsis risk stratification. Disclosures Ephraim L. Tsalik, MD PhD, Danaher Diagnostics, Predigen, and Biomeme: In the past 3 years, I have had held equity and consulted for Predigen and Biomeme. Currently, I am an employee of Danaher Diagnostics. Christopher W. Woods, MD MPH, Predigen, Inc: Co-founder.
Neural growth factor expression in the lateral retinaculum in painful patellofemoral malalignment (2001)

We studied 7 samples of lateral retinaculae excised at the time of surgical realignments. They were obtained from patients with isolated symptomatic patellofemoral malalignment resistant to conservative treatment and were evaluated with immunohistochemistry and immunoblotting. We found that neural growth factor is higher in patients with pain than in those with instability as the main symptom. Neural growth factor is related to neural proliferation in vessels and perivascular tissue and to the release of neuroceptive transmitters, such as substance P. We postulate that both mechanisms are involved in the pathogenesis of pain in isolated symptomatic patellofemoral malalignment.
Push vs. pull (2000)

As the performance gap between the CPU and main memory continues to grow, techniques to hide memory latency are essential to deliver a high performance computer system. Prefetching can often overlap memory latency with computation for array-based numeric applications. However, prefetching for pointer-intensive applications still remains a challenging problem. Prefetching linked data structures (LDS) is difficult because the address sequence of LDS traversal does not present the same arithmetic regularity as array-based applications and the data dependence of pointer dereferences can serialize the address generation process.
On the SER and spectral analyses of A-law companded multicarrier modulation (2003)

A peak-to-average power ratio (PAPR) reduction technique based on A-law companding is proposed for a multicarrier modulation (MCM) system. Multicarrier modulation is also known as orthogonal frequency-division multiplexing (OFDM) or digital multitone. The symbol error rate (SER) and spectral property of the companded MCM system are investigated. The SER and spectral performance of the proposed system are also compared with the uncompanded MCM system.
Serogroup-Specific Bacterial Engineered Glycoproteins as Novel Antigenic Targets for Diagnosis of Shiga Toxin-Producing-Escherichia coli-Associated Hemolytic-Uremic Syndrome (2014)

Human infection with Shiga toxin-producing Escherichia coli (STEC) is a major cause of postdiarrheal hemolytic-uremic syndrome (HUS), a life-threatening condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. E. coli O157:H7 is the dominant STEC serotype associated with HUS worldwide, although non-O157 STEC serogroups can cause a similar disease. The detection of anti-O157 E. coli lipopolysaccharide (LPS) antibodies in combination with stool culture and detection of free fecal Shiga toxin considerably improves the diagnosis of STEC infections. In the present study, we exploited a bacterial glycoengineering technology to develop recombinant glycoproteins consisting of the O157, O145, or O121 polysaccharide attached to a carrier protein as serogroup-specific antigens for the serological diagnosis of STEC-associated HUS. Our results demonstrate that using these antigens in indirect ELISAs (glyco-iELISAs), it is possible to clearly discriminate between STEC O157-, O145-, and O121-infected patients and healthy children, as well as to confirm the diagnosis in HUS patients for whom the classical diagnostic procedures failed. Interestingly, a specific IgM response was detected in almost all the analyzed samples, indicating that it is possible to detect the infection in the early stages of the disease. Additionally, in all the culture-positive HUS patients, the serotype identified by glyco-iELISAs was in accordance with the serotype of the isolated strain, indicating that these antigens are valuable not only for diagnosing HUS caused by the O157, O145, and O121 serogroups but also for serotyping and guiding the subsequent steps to confirm diagnosis.
The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro (2016)

In this study, stable, homogenous and thin titania dioxide coatings (TiO2) on stainless steel substrate doped with two dosages of bioactive sphingolipids S1P were fabricated using the sol-gel method. S1P belongs to a family of sphingolipids acting as important extracellular signaling molecules and chemoattractants. This study investigated the effect of TiO2, doped with S1P in two different dosages on cellular response as well as osteogenic differentiation potential of human adipose derived multipotent stromal stem cells (hASC). The authors have shown that S1P mediates hASCs morphology, proliferation activity and population doubling time in a dose-dependent manner. They have also demonstrated that functionalization of TiO2coating with a higher dosage of S1P, i.e. 80 ng/ml [(TiO2/S1P(CII)] activated both S1PR type 1 and type 2 on mRNA level. The results indicated an increase in secretion of BMP-2, Osteopontin and Osteocalcin by osteoblasts progenitor when cultured on [TiO2/S1P(CIIm)]. In addition, the authors observed the highest extracellular matrix mineralization as well as osteonodules formation by the osteoblasts precursors when cultured onto [TiO2/S1P(CIIm)].
Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes (2018)

Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia characterized by leukemic blasts presenting myeloid and lymphoid markers. Here we report data from integrated genomic analysis on 31 MPAL samples and compare molecular profiling with that from acute myeloid leukemia (AML), B cell acute lymphoblastic leukemia (B-ALL), and T cell acute lymphoblastic leukemia (T-ALL). Consistent with the mixed immunophenotype, both AML-type and ALL-type mutations are detected in MPAL. Myeloid-B and myeloid-T MPAL show distinct mutation and methylation signatures that are associated with differences in lineage-commitment gene expressions. Genome-wide methylation comparison among MPAL, AML, B-ALL, and T-ALL sub-classifies MPAL into AML-type and ALL-type MPAL, which is associated with better clinical response when lineage-matched therapy is given. These results elucidate the genetic and epigenetic heterogeneity of MPAL and its genetic distinction from AML, B-ALL, and T-ALL and further provide proof of concept for a molecularly guided precision therapy approach in MPAL.
Self-Assembled Monolayers Assisted all Wet Metallization of SU-8 Negative Tone Photoresist (2020)

The present work investigates the application of a Self-Assembled Monolayer (SAM) on the widely used negative photoresist SU-8. (3-Aminopropyl) trimethoxysilane (APTMS) is employed to form SAMs on the surface of the polymer through wet silanization in ethanol. The treatment process of SU-8 resin surface is optimized to achieve a well-formed, high quality SAM. Wettability measurements, atomic force microscopy (AFM) and infrared (IR) spectroscopy are employed to follow and optimize the silanization process. Following silanization, the resulting SAMs are employed as adhesion layers for electroless plated metallic layers. For this purpose, the superior affinity of APTMS amine terminal groups towards Pd 2+ ions is exploited to activate the surface. Metallic coatings such as Cu, Ni–P or Co–Ni–P are thus deposited by mean of autocatalytic deposition. The surface of metallized samples is analyzed using AFM, scanning electron microscopy (SEM) and glow discharge optical emission spectroscopy (GDOES). Finally, Ni–P is deposited on a micropatterned SU-8 surface to demonstrate the potential of the presented metallization approach for microfabrication.
ChemInform Abstract: N,N‐DIHALOETHANEDIIMIDOYL DIFLUORIDES (1983)

Abstract Aus den Komponenten Dicyan (I) und C1, entsteht in Gegenwart von HgFz unter Ausschluß von Feuchtigkeit nach 4‐tägigem 4 Stehen bei Zimmertemperatur (RT) und 48 h bei 150°C ein Gemisch der Produkte (IIa)‐(IVa).
An enhanced apoptosis and a reduced angiogenesis are associated with the inhibition of lung colonisation in animals fed ann-3 polyunsaturated fatty acid-rich diet injected with a highly metastatic murine melanoma line (2008)

Both epidemiological and experimental studies indicate that dietary n-3 PUFA inhibit carcinogenesis and tumour growth. Metastatic diffusion has also been found to be affected in animals fed diets containing purified n-3 PUFA or fish oil. In the present study, we investigated whether the metastatic diffusion of a highly metastatic variant (F10-SR cells) isolated from the B16 melanoma F10 line was affected by feeding host animals a diet containing 5 % fish oil. In these animals, compared with those fed a diet containing 5 % maize oil, there was a reduced number of metastatic pulmonary colonies. The immunohistochemical analysis of appropriate markers revealed that the antimetastatic effect of dietary n-3 PUFA was not related to a reduction of proliferation, but rather to an enhanced apoptotic activity. The reduction of von Willebrand factor immunoreactivity found in pulmonary colonies of F10-SR cells grown in fish oil-fed animals indicates that a decrease of angiogenesis contributes to the antimetastatic effect of dietary n-3 PUFA. This conclusion stands in spite of the higher expression of vascular endothelial growth factor observed in pulmonary colonies grown in fish oil-fed animals.
Present and future therapeutic strategies in non-alcoholic fatty liver disease (2007)

Non-alcoholic fatty liver disease (NAFLD) is found in individuals who do not drink or abuse alcohol and represents a significant health burden for the general community. NAFLD is often associated with one or more features of the metabolic syndrome and has potential for evolution towards non-alcoholic steatohepatitis (NASH), the necro-inflammatory form of liver steatosis. The most worrisome evolutive events in a subgroup of NASH patients include advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. Pathophysiology of NAFLD/NASH is complex, but studies point to a pre-eminent role of oxidative stress and lipid peroxidation in the liver, including early mitochondrial dysfunction. Changes follow an insulin resistance status with a background of a chronic pro-inflammatory status due to an excess of visceral adiposity. Although no established therapy exists for NAFLD/NASH, potential therapeutic approaches are discussed in this review.
Construction of fluorescent red silk using fibroin H-chain expression system (2012)

본 연구의 목적은 누에형질전환 기술을 이용하여 적색형광실크를 개발하는 것으로서, 본 실험에서는 피브로인 H-chain의 N-말단과 C-말단을 이용하여 피브로인 재조합 단백질 발현 시스템을 제작하였고, 종결 코돈이 없는 DsRed2 유전자를 위의 발현 시스템에 클로닝하여 적색형광실크를 제작하였다. 누에형질전환체 선발을 위해서는 3xP3 promoter와 EGFP 유전자를 이용하여 선발하였고, 1020개의 누에알에 microinjection 하여 F1 세대에서 6 broods의 형질전환체를 선발하였다. 선발된 누에형질전환체는 초기배 단계의 눈과 신경조직, 유충과 번데기 그리고 성충의 눈에서 EGFP 형광단백질이 발현되는 것을 확인 할 수 있었다. 또한 실크의 피브로인에서 DsRed2 단백질이 발현되는 것을 확인하기 위해, F2세대의 누에형질전환체 중에서 5령 5일 유충을 해부하여 견사선을 형광현미경으로 관찰하였고, 중부와 후부 견사선에서 적색형광단백질이 발현되는 것을 확인 할 수 있었고, F2 세대의 고치에서도 적색형광단백질의 발현을 확인할 수 있었다. 이상의 결과에서 적색형광실크를 생산하는 누에형질전환체가 성공적으로 제작되었음을 확인할 수 있었고 이러한 결과를 토대로 새로운 산업소재로서 실크를 활용할 수 있을 것으로 기대한다. We constructed the fibroin H-chain expression system to produce Discosoma sp. red fluorescent protein variant2 (DsRed2) in transgenic silkworm cocoon. Fluorescent cocoon could be made by fusing DsRed2 cDNA to the heavy chain gene and injecting it into a silkworm. The DsRed2 fusion protein, each with N- and C-terminal sequences of the fibroin H-chain, was designed to be secreted into the lumen of the posterior silk glands. The expression of the DsRed2/H-chain fusion gene was regulated by the fibroin H-chain promoter. The use of the 3xP3-driven EGFP cDNA as a marker allowed us to rapidly distinguish transgenic silkworms. The EGFP fluorescence became visible in the ocelli and in the central and peripheral nervous system on the seventh day of embryonic development. A mixture of the donor and helper vector was micro-injected into 1,020 Kumokjam, bivoltin silkworm eggs. We obtained 6 broods. The cocoon was displayed strong red fluorescence, proving that the fusion protein was present in the cocoon. Accordingly, we suggest that the DsRed2 fluorescence silk will enable the production of novel biomaterial based on the transgenic silk.
Remotely operated brachytherapy system for oral cancer (2013)

This paper presents the development of a remotely operated brachytherapy system for oral cancer. The purpose of the system is to reduce exposure dose to the operator by keeping him or her at a distance of 1m from radioactive <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">198</sup> Au sources. The system is designed to enable the operator to perform the same procedure as for conventional brachytherapy treatment without exposure dose. It consists of an applicator manipulator to implant <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">198</sup> Au seeds, a finger device to firmly grasp organs in the mouth, operational parts for both of them, and a base arm. The applicator manipulator and finger device are fixed on the base arm which is fixed on a radiation shield. The applicator manipulator is a serial manipulator with five degrees of freedom (DOF). The finger device is necessary because organs in the mouth are soft and flexible. Its finger and operational parts are identical three DOF parallel manipulators. This paper details preliminary experiments of grasping and insertion with the system. These experiments verify that an operator can grasp a tongue model with the finger device and can insert the applicator into it with the applicator manipulator. In our developed system, we also confirm that rotation of the applicator needle can reduce insertion force.
Popular Matchings: Good, Bad, and Mixed (Invited Talk) (2019)

We consider the landscape of popular matchings in a bipartite graph G where every vertex has strict preferences over its neighbors. This is a very well-studied model in two-sided matching markets. A matching M is popular if it does not lose a head-to-head election against any matching, where each vertex casts a vote for the matching where it gets a better assignment. Roughly speaking, a popular matching is one such that there is no matching where more vertices are happier. The notion of popularity is more relaxed than stability: a classical notion studied for the last several decades. Popular matchings always exist in G since stable matchings always exist in a bipartite graph and every stable matching is popular. Algorithmically speaking, the landscape of popular matching seems to have only a few bright spots. Every stable matching is a min-size popular matching and there are also simple linear time algorithms for computing a max-size popular matching and for the popular edge problem. All these algorithms reduce the popular matching problem to an appropriate question in stable matchings and solve the corresponding stable matching problem. We now know NP-hardness results for many popular matching problems. These include the min-cost/max-weight popular matching problem and the problem of deciding if G admits a popular matching that is neither a min-size nor a max-size popular matching. For non-bipartite graphs, it is NP-hard to even decide if a popular matching exists or not. A mixed matching is a probability distribution or a lottery over matchings. A popular mixed matching is one that never loses a head-to-head election against any mixed matching. As an allocation mechanism, a popular mixed matching has several nice properties. Moreover, finding a max-weight or min-cost popular mixed matching in G is easy (by solving a linear program). Interestingly, there is always an optimal popular mixed matching Pi with a simple structure: Pi = {(M_0,1/2),(M_1,1/2)} where M_0 and M_1 are matchings in G. Popular mixed matchings always exist in non-bipartite graphs as well and can be computed in polynomial time.