gebhart/patrepeval huggingface dataset:
Glomus jugulare tumors long-term control by radiation therapy (1992)

The records of 49 patients with glomus jugulare tumor seen at the University of Virginia from 1932 to 1985 were retrospectively reviewed with the objective of assessing long-term results of treatment. Follow-up ranged from 5 to 31 years, with a minimum of 10 years in 36 patients (73%). According to McCabe's classification, 17 patients (35%) were Group I, 11 patients (22%) were Group II, and 21 patients (43%) were Group III. Analysis by therapeutic technique revealed that 20 patients received surgery alone (41%), 15 patients received radiation therapy alone (31%), and 14 patients received combined therapy (28%). Only 7 patients (14%) have had clinical or radiologic evidence of disease progression. Three of these patients were treated by surgery alone and three by a combination of surgery and radiation, but the dose was less than 4000 cGy. Only one patient treated by radiation therapy alone or with surgery and radiation to a dose in excess of 4000 cGy demonstrated disease progression. Salvage radiation therapy was given to three of the seven patients when progressive disease was detected. Radiation therapy is an effective treatment for glomus jugulare tumor with minimal late progression of disease in adequately treated patients and no significant long-term complications.
Novel branched poly(ɛ‐caprolactone) as a nonmigrating plasticizer in flexible PVC: Synthesis and characterization (2018)

ABSTRACT A series of hyperbranched poly(ɛ‐caprolactone) (HPCLs, denoted as D X ) with different molecular weights were synthesized by the copolymerization of GPCL (PCL initiated by glycidol) and succinic anhydride. The chemical structure of D X was characterized by 1 H‐NMR gel permeation chromatography and inherent viscosity, and D X was used as the plasticizer for poly(vinyl chloride) (PVC) compared to traditional plasticizer di‐(ethylhexyl) phthalate (DEHP). The thermal properties, morphology, mechanical properties, and migration stabilities of PVC films were explored with differential scanning calorimetry, thermogravimetric analysis, scanning electron microscope, tensile, and migration tests. PVC/D 1 exhibited the best plasticization efficiency up to 107%, with enhanced tensile strength (18.5 MPa) and ultimate elongation (416%) compared to PVC/DEHP (11.5 MPa and 375%, respectively). PVC/D 1 exhibited remarkably high plasticization efficiency as compared to PVC/DEHP at a plasticizer concentration of PVC below 40 wt %. Moreover, the migration test for PVC/D X films exhibited minimal plasticizers migration even at very harsh conditions. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46542.
Trajectory generation of CPM device for the elbow joint considering constraint caused by joint disorder (2009)

Continuous passive motion (CPM) is an orthopedic treatment or a physiotherapy after surgery. After surgery to injury of ulna collateral ligament (UCL) in the elbow, excessive extension of the UCL aggravates the injury, and reaction force at hand of patient increases excessively near the end of the range of motion due to increased stiffness. It is known that controlling pro-/supination is effective to suppress the reaction force, but the UCL may be extended excessively by the pro-/supination. In this paper, we focus on the treatment after the surgery to UCL and propose the trajectory generation method to control the pro-/supination in order to suppress both the reaction force and the UCL extension based on skeleton model. Finally, experimental results with simulated patient show the effectiveness of the proposed method.
Activation-induced cell death in proliferating T cells is associated with altered tyrosine phosphorylation of TCR/CD3 subunits. (1994)

The first signaling event that occurs after stimulation of the TCR is an increase in the tyrosine phosphorylation of a number of proteins including the TCR-zeta chain and CD3 subunits. It is known that proliferating T cells respond differently to TCR stimulation when compared with naive T cells. Stimulation of the TCR on proliferating T cells has been shown to result in cell death by apoptosis, a process referred to as activation-induced cell death (AICD). In this study we have determined the pattern of tyrosine phosphorylation of TCR-zeta and the CD3 subunits of naive and proliferating CD4- CD8+ T cells that express a transgenic TCR that is specific for the male Ag presented by Db class I molecules after TCR stimulation. AICD in proliferating T cells was mediated by stimulation with anti-TCR/CD3, but not anti-Thy-1, anti-CD8, or anti-Db mAbs. When compared with naive T cells, tyrosine phosphorylation of TCR-zeta was dramatically decreased in proliferating cells. Furthermore, whereas CD3 delta, CD3 epsilon, and CD3 gamma of naive T cells were phosphorylated in a 1:2:1 ratio after TCR stimulation, these subunits in proliferating T cells were tyrosine phosphorylated in a 1:1:0 ratio after TCR stimulation. Altered phosphorylation of these subunits was not caused by the lack of synthesis or amount of these proteins in proliferating cells. This is the first study implicating altered tyrosine phosphorylation of TCR/CD3 subunits in AICD.
Stable aqueous dispersions of ZnO nanoparticles for ink-jet printed gas sensors (2010)

For the preparation of printable devices based on ZnO nanoparticles (ZnO NP), stable colloidal dispersions of these materials are highly desirable. ZnO NP have been synthesized by chemical vapor synthesis. The particles have a spherical shape with a narrow size distribution. Stable aqueous dispersions of the ZnO NP have been successfully prepared after the addition of a polymeric stabilizer. The prepared dispersions are stable for at least 2 months without observable sedimentation. These stable dispersions are used to prepare ZnO NP films on different substrates by ink-jet printing. The viscosity and the surface tension of the dispersion as well as the printing parameters have been optimized for forming layers with high quality. Dense and low porosity layers of ZnO NP with a thickness between 100-250 nm have been prepared on different substrates. First measurements on ink-jet printed ZnO films are done on self fabricated inter digital capacitors (IDCs) at room temperature. The ZnO films show resistivity at room temperature of 7.76 k¿.cm. For sensing measurements in hydrogen atmosphere, the sheet resistance decreases rapidly until it reaching metallic behavior. This behavior is reversible.
Research on Creating Multi-Attribute Power Consumption Behavior Portraits for Massive Users (2018)

With the gradual opening of electricity sales markets in China and continuous development of integrated energy systems, problems such as diversified and improper user energy consumption modes are becoming more prominent, and user behavior analyses under market environments are apparently insufficient. Multi-attribute power consumption behavior portraits including user characteristics, pattern, group character and individuality should be established to provide a theoretical basis for intelligent power consumption technologies based on coordinated “source-network-load” interactions. In this paper, based on massive user data from various industries, a pattern of user behavior is extracted from three perspectives: temperature sensitivity, electricity price sensitivity and power consumption stationarity. Characteristic indexes are created and quantified for comprehensive evaluation. User power consumption behavior tags are created. Finally, based on a fuzzy c-means (FCM) clustering algorithm, a multi-attribute user power consumption behavior portrait with quantified, classified and combined tags is created.
A SEMANTIC GRAPH DATABASE FOR BIM-GIS INTEGRATED INFORMATION MODEL FOR AN INTELLIGENT URBAN MOBILITY WEB APPLICATION (2018)

Abstract. Over the recent years, the usage of semantic web technologies and Resources Description Framework (RDF) data models have been notably increased in many fields. Multiple systems are using RDF data to describe information resources and semantic associations. RDF data plays a very important role in advanced information retrieval, and graphs are efficient ways to visualize and represent real world data by providing solutions to many real-time scenarios that can be simulated and implemented using graph databases, and efficiently query graphs with multiple attributes representing different domains of knowledge. Given that graph databases are schema less with efficient storage for semi-structured data, they can provide fast and deep traversals instead of slow RDBMS SQL based joins allowing Atomicity, Consistency, Isolation and durability (ACID) transactions with rollback support, and by utilizing mathematics of graph they can enormous potential for fast data extraction and storage of information in the form of nodes and relationships. In this paper, we are presenting an architectural design with complete implementation of BIM-GIS integrated RDF graph database. The proposed integration approach is composed of four main phases: ontological BIM and GIS model’s construction, mapping and semantic integration using interoperable data formats, then an import into a graph database with querying and filtering capabilities. The workflows and transformations of IFC and CityGML schemas into object graph databases model are developed and applied to an intelligent urban mobility web application on a game engine platform validate the integration methodology.
Magnetomechanical Transport of Liquid Metal Droplets via Asymmetric Microwall Arrays (2022)

Abstract Eutectic gallium indium liquid metal (LM) is a promising conductive liquid for various electronic applications. In particular, the directional transport of LM droplets has potential applications in soft electronics to control electrical conductivity. Existing methods transport LM droplets by applying an electric field to generate an interfacial tension difference within the LM droplet due to nonuniform ionic distribution of the electrical double layer. However, these methods require confined channels and tethered systems to apply the electric field. In this study, channel‐free wireless transport of LM droplets is demonstrated via on‐demand magnetomechanical actuation of asymmetric microwall arrays comprising vertically aligned ferromagnetic iron particles embedded in polydimethylsiloxane. Asymmetric microwall of two different widths is designed to generate an asymmetric bending stiffness at a given magnetic field. The asymmetric microwall bends gradually in response to a linear external magnetic field perpendicular to the alignment axis of the iron particles. Therefore, nonuniform magnetomechanical bending induces a local height gradient along the microwall, causing gravitational‐force‐driven roll‐off motion of the LM droplet. Transport direction of LM droplet is modulated by varying the geometric parameters. Finally, the opposite‐directional transport of two LM droplets is demonstrated under a linear magnetic field by pre‐programming the asymmetric bending direction of each microwall array.
FLAVS: a fault localization add-in for visual studio (2015)

Dynamic fault localization is a representative concept and product proposed by academia to alleviate software engineering pains, but it is rarely heard adopted or used in realistic development. Realizing the difficulties in transferring the approaches of dynamic fault localization to practical tools, this paper gives our work FLAVS, whose add-in implementation organically and seamlessly integrates the approach of dynamic fault localization with software IDEs. The tool is useful for developers using Microsoft Visual Studio platform to debug and test programs with complex bugs. Besides, it is also valuable for researchers to design new fault localization methods and draw performance comparison among different method candidates.
Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma (2017)

Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies in CCOC have revealed expression profiles consistent with increased hypoxia, and our previous data suggest that hypoxia is correlated with increased autophagy in CCOC. Hypoxia-induced autophagy is a key factor promoting tumor cell survival and resistance to therapy. Recent clinical trials with the molecular-targeted receptor tyrosine kinase (RTK) inhibitor sunitinib have demonstrated limited activity. Here, it was evaluated whether the hypoxia-autophagy axis could be modulated to overcome resistance to sunitinib. Importantly, a significant increase in autophagic activity was found with a concomitant loss in cell viability in CCOC cells treated with sunitinib. Pharmacologic inhibition of autophagy with the lysosomotropic analog Lys05 inhibited autophagy and enhanced sunitinib-mediated suppression of cell viability. These results were confirmed by siRNA targeting the autophagy-related gene <i>Atg5</i> In CCOC tumor xenografts, Lys05 potentiated the antitumor activity of sunitinib compared with either treatment alone. These data reveal that CCOC tumors have an autophagic dependency and are an ideal tumor histotype for autophagy inhibition as a strategy to overcome resistance to RTK inhibitors like sunitinib.<b>Implications:</b> This study shows that autophagy inhibition enhances sunitinib-mediated cell death in a preclinical model of CCOC. <i>Mol Cancer Res; 15(3); 250-8. ©2017 AACR</i>.
SO<sub>2</sub> oxidation products other than H<sub>2</sub>SO<sub>4</sub> as a trigger of new particle formation ? Part 2: Comparison of ambient and laboratory measurements, and atmospheric implications (2008)

Atmospheric new particle formation is generally thought to occur due to homogeneous or ion-induced nucleation of sulphuric acid. We compare ambient nucleation rates with laboratory data from nucleation experiments involving either sulphuric acid or oxidized SO<sub>2</sub>. Atmospheric nucleation occurs at H<sub>2</sub>SO<sub>4</sub> concentrations 2–4 orders of magnitude lower than binary or ternary nucleation rates of H<sub>2</sub>SO<sub>4</sub> produced from a liquid reservoir, and atmospheric H<sub>2</sub>SO<sub>4</sub> concentrations are very well replicated in the SO<sub>2</sub> oxidation experiments. We hypothesize these features to be due to the formation of free HSO<sub>5</sub> radicals in pace with H<sub>2</sub>SO<sub>4</sub> during the SO<sub>2</sub> oxidation. We suggest that at temperatures above ~250 K these radicals produce nuclei of new aerosols much more efficiently than H<sub>2</sub>SO<sub>4</sub>. These nuclei are activated to further growth by H<sub>2</sub>SO<sub>4</sub> and possibly other trace species. However, at lower temperatures the atmospheric relative acidity is high enough for the H<sub>2</sub>SO<sub>4</sub>–H<sub>2</sub>O nucleation to dominate.
GRIP: Generative Robust Inference and Perception for Semantic Robot Manipulation in Adversarial Environments (2019)

Recent advancements have led to a proliferation of machine learning systems used to assist humans in a wide range of tasks. However, we are still far from accurate, reliable, and resource-efficient operations of these systems. For robot perception, convolutional neural networks (CNNs) for object detection and pose estimation are recently coming into widespread use. However, neural networks are known to suffer from overfitting during the training process and are less robust under unforeseen conditions (which makes them especially vulnerable to adversarial scenarios). In this work, we propose Generative Robust Inference and Perception (GRIP) as a two-stage object detection and pose estimation system that aims to combine the relative strengths of discriminative CNNs and generative inference methods to achieve robust estimation. Our results show that a second stage of sample-based generative inference is able to recover from false object detections by CNNs, and produce robust estimations in adversarial conditions. We demonstrate the efficacy of GRIP robustness through comparison with state-of-the-art learning-based pose estimators and pick-and-place manipulation in dark and cluttered environments.
Greybox fuzzing as a contextual bandits problem (2018)

Greybox fuzzing is one of the most useful and effective techniques for the bug detection in large scale application programs. It uses minimal amount of instrumentation. American Fuzzy Lop (AFL) is a popular coverage based evolutionary greybox fuzzing tool. AFL performs extremely well in fuzz testing large applications and finding critical vulnerabilities, but AFL involves a lot of heuristics while deciding the favored test case(s), skipping test cases during fuzzing, assigning fuzzing iterations to test case(s). In this work, we aim at replacing the heuristics the AFL uses while assigning the fuzzing iterations to a test case during the random fuzzing. We formalize this problem as a `contextual bandit problem' and we propose an algorithm to solve this problem. We have implemented our approach on top of the AFL. We modify the AFL's heuristics with our learned model through the policy gradient method. Our learning algorithm selects the multiplier of the number of fuzzing iterations to be assigned to a test case during random fuzzing, given a fixed length substring of the test case to be fuzzed. We fuzz the substring with this new energy value and continuously updates the policy based upon the interesting test cases it produces on fuzzing.
NON-BACKDRIVABLE SERIES ELASTIC ACTUATOR FOR USE IN A PROSTHETIC ELBOW (2005)

Commercially available prosthetic elbows have stiff actuators (motors) that are only\ncapable of motion (position or velocity) control. In an attempt to mimic human physiology while\naccommodating prosthetic demands, a non-backdrivable motor has been created that is less stiff\nand capable of impedance control. Impedance control responds well to different environments\nand the presence of perturbations. Results have shown that this motor, though non-backdrivable\nto ensure sufficient battery supply, is still capable of exerting sufficient torque, speed, and\nfrequency bandwidth to be useful in prosthetics. In the future, patients will be fit with this type of\nmotor to examine if they objectively and subjectively perform better using this more\nphysiologically appropriate prosthesis.
It takes a village to raise the world. (2009)

My experience in Tanzania has not only made me a better person, but also a better nurse. Creating this organization has been an awesome challenge. It is through Duluti Initiative, Inc. that I can give of myself and create opportunities for others who share in this mission. The mission of Duluti Initiative, Inc. is to decrease mortality and morbidity of the people of Tanzania, Africa by providing funds and access to healthcare. Here is how you can get involved. Donate. $15, for example, will supply a woman in our Expectant Mothers program with nutritious fruits and vegetables for one month. Spread the word! Contact us! http://duluti.org/. We would love to know your thoughts. Send us an e-mail about fundraising or other ways to contribute. Use the search engine www.goodsearch.com. Simply click the box that indicates which charity the search is for, enter duluti and click verify. For every search you conduct, Duluti Initiative, Inc. receives one penny. If 100 people use this search engine and conduct 10 searches per day for one year, at the end of the year Duluti Initiative, Inc. will receive a check for $3,650! Imagine what a contribution you can make! The best part is, all it costs is a little of your time. My experience in Tanzania has reinforced the importance of having strong nursing assessment skills, being able to think critically, and having a willingness to listen. Nursing is a "portable career" that we can take to any location on the planet and make a difference in someone's life. As nurses, we often take what we do for granted--but those that we help, do not.
Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC (2011)

Mitochondrial DNA (mtDNA) is entirely dependent on nuclear genes for its transcription and replication. One of these genes is TOP1MT, which encodes the mitochondrial DNA topoisomerase IB, involved in mtDNA relaxation. To elucidate TOP1MT regulation, we performed genome-wide profiling across the 60-cell line panel (the NCI-60) of the National Cancer Institute Developmental Therapeutics Program. We show that TOP1MT mRNA expression varies widely across these cell lines with the highest levels in leukemia (HL-60, K-562) and melanoma (SK-MEL-28), intermediate levels in breast (MDA-MB-231), ovarian (OVCAR) and colon (HCT-116, HCT-15, KM-12), and lowest levels in renal (ACHN, A498), prostate (PC-3, DU-145) and central nervous system cell lines (SF-539, SF-268, SF-295). Genome-wide analyses show that TOP1MT expression is significantly correlated with the other mitochondrial nuclear-encoded genes including the mitochondrial nucleoid genes, and demonstrate an overall co-regulation of the mitochondrial nuclear-encoded genes. We also find very high correlation between the expression of TOP1MT and the proto-oncogene MYC (c-myc). TOP1MT contains E-boxes (c-myc binding sites) and TOP1MT transcription follows MYC up- and down-regulation by MYC promoter activation and siRNA against MYC. Our finding implicates MYC as a novel regulator of TOP1MT and confirms its role as a master regulator of MNEGs and mitochondrial nucleoids.
Optically Pumped Nuclear Magnetometer (1963)

A continuous recording total earth's field magnetometer has been demonstrated which utilizes optical pumping in He3 and the resultant polarization of the nuclear spins. The device operates as a ``self-oscillator'' at the Larmor frequency of the ground state atoms. The oscillator has a ``Q'' of 104 in a 0.5-G field. The sensitivity of the instrument to fluctuations in the magnetic field is presently several microgauss. The characteristics and operating principles of the instrument are described. The application of the device to the measurement of the absolute value of the total external magnetic field is discussed.
Surface Binding of Polypyrrole on Porous Silicon Hollow Nanospheres for Li‐Ion Battery Anodes with High Structure Stability (2014)

Uniform porous silicon hollow nano-spheres are prepared without any sacrificial templates through a magnesio-thermic reduction of mesoporous silica hollow nanospheres and surface modified by the following in situ chemical polymerization of polypyrrole. The porous hollow structure and polypyrrole coating contribute significantly to the excellent structure stability and high electrochemical performance of the nanocomposite.