gebhart/patrepeval huggingface dataset:
Variabilité génomique des souches de Staphylococcus aureus (2009)

Staphylococcus aureus est une bacterie pathogene majeure pour l'Homme et les animaux a sang chaud, tristement celebre pour son exceptionnelle resistance aux traitements antibiotiques et son implication dans les infections nosocomiales.
S. aureus dispose d'un impressionnant arsenal de facteurs de virulence qui lui permet de coloniser la peau et les muqueuses de ces hotes et d'y persister de facon asymptomatique. A la faveur d'une blessure ou d'une baisse de l'efficacite du systeme immunitaire de l'hote, S. aureus peut declencher un large panel d'infections opportunistes allant du simple furoncle a la septicemie mortelle.
Dans l'optique de repondre aux questions que cette bacterie suscite, cet ouvrage se presente comme une synthese abordant tous ses aspects : taxonomie, ecologie, physiologie, pouvoir pathogene, epidemiologie, controle et prevention.
Une place importante est donnee a l'antibioresistance, aux facteurs de virulence, a leur regulation et aux infections a S. aureus chez l'homme. Les infections chez l'animal sont largement abordees de meme que l'implication de S. aureus dans les toxi-infections alimentaires. Sont detailles des approches tres pragmatiques tels que les methodes d'identification de l'espece et de differenciation des souches de S. aureus ou les methodes de detection dans les aliments (appliquees a la bacterie elle-meme ou a ses toxines). Ses aspects sont completes par les donnees les plus recentes concernant sa classification, son genome, ses besoins nutritionnels, ses strategies de survie et de resistance aux stress et aux antibiotiques, son etiopathogenie, les sources de contamination, les elements reglementaires.
Une trentaine de specialistes d'horizons varies (bacteriologie medicale et veterinaire, securite alimentaire, recherche fondamentale) se sont associes pour rediger cet ouvrage complet, didactique et riche d'une bibliographie de plus d'un millier de references.
Staphylococcus aureus s'adresse aux biologistes medicaux, aux techniciens d'analyses, aux enseignants de microbiologie et aux etudiants en BTS, IUT, Master ou preparant une formation superieure en microbiologie.
SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells (2017)

<b>Purpose:</b> We previously demonstrated an association between decreased <i>SMAD4</i> expression and cetuximab resistance in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to further elucidate the clinical relevance of SMAD4 loss in HNSCC.<b>Experimental Design:</b> SMAD4 expression was assessed by IHC in 130 newly diagnosed and 43 patients with recurrent HNSCC. Correlative statistical analysis with clinicopathologic data was also performed. OncoFinder, a bioinformatics tool, was used to analyze molecular signaling in TCGA tumors with low or high <i>SMAD4</i> mRNA levels. The role of SMAD4 was investigated by shRNA knockdown and gene reconstitution of HPV-negative HNSCC cell lines <i>in vitro</i> and <i>in vivo</i><b>Results:</b> Our analysis revealed that SMAD4 loss was associated with an aggressive, HPV-negative, cetuximab-resistant phenotype. We found a signature of prosurvival and antiapoptotic pathways that were commonly dysregulated in <i>SMAD4</i>-low cases derived from TCGA-HNSCC dataset and an independent oral cavity squamous cell carcinoma (OSCC) cohort obtained from GEO. We show that <i>SMAD4</i> depletion in an HNSCC cell line induces cetuximab resistance and results in worse survival in an orthotopic mouse model <i>in vivo</i> We implicate JNK and MAPK activation as mediators of cetuximab resistance and provide the foundation for the concomitant EGFR and JNK/MAPK inhibition as a potential strategy for overcoming cetuximab resistance in HNSCCs with SMAD4 loss.<b>Conclusions:</b> Our study demonstrates that loss of SMAD4 expression is a signature characterizing the cetuximab-resistant phenotype and suggests that SMAD4 expression may be a determinant of sensitivity/resistance to EGFR/MAPK or EGFR/JNK inhibition in HPV-negative HNSCC tumors. <i>Clin Cancer Res; 23(17); 5162-75. ©2017 AACR</i>.
Effective and accurate representation of extended Bloch states on finite Hilbert spaces (2013)

We present a straightforward, noniterative projection scheme that can represent the electronic ground state of a periodic system on a finite atomic-orbital-like basis, up to a predictable number of electronic states and with controllable accuracy. By cofiltering the projections of plane-wave Bloch states with high-kinetic-energy components, the richness of the finite space and thus the number of exactly-reproduced bands can be selectively increased at a negligible computational cost, an essential requirement for the design of efficient algorithms for electronic structure simulations of realistic material systems and massive high-throughput investigations.
Final report on the APMP comparison of capacitance at 100 pF (APMP supplementary comparison APMP.EM-S7) (2008)

A comparison of capacitance at 100 pF was conducted between thirteen participating laboratories from the Asia-Pacific region. Measurements were made over the period 2004 to 2006. The behaviour of the travelling artefact was consistent with a steady linear drift at a rate of less than 0.1 µF/F per year. Despite the wide range of capabilities within the region, the results showed good agreement between all participating laboratories.
Micromotion-induced dynamic effects from a neuron probe and brain tissue interface (2013)

Brain cells interfaced with electrical neural implants are utilized to gain a better understanding of the functionality of our nervous system. One main problem that exists with these neural implants is the potential to cause injury to surrounding neural cells due to a discrepancy in stiffness values between the implant and surrounding brain tissue when subjected to mechanical micromotion of the brain. To evaluate the effects of the mechanical mismatch, a series of dynamic simulations are conducted to better understand the design enhancements required to improve the feasibility of the neuron probe. In addition, the brain tissue deformation near the interface of the neuron probe can give insight on the extent of injury to the brain due to relative micromotion. The simulations use a nonlinear transient explicit finite element code, LS-DYNA. A three-dimensional quarter-symmetry finite element model is utilized for the transient analysis to capture the time-dependent dynamic deformations on the brain tissue from the implant as a function of different frequency shapes and stiffness values.
Noninvasive Autofluorescence Imaging for Tracking and Monitoring the Progression of Oral Premalignant Lesions (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. Cherry, R. A. Schwarz, E. Yang, H. Badaoui, M. D. Williams, N. Vigneswaran, A. M. Gillenwater, and R. Richards-Kortum, "Noninvasive autofluorescence imaging for tracking and monitoring the progression of oral premalignant lesions," in Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optica Publishing Group, 2018), paper CTu2B.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
ChemInform Abstract: TOTAL SYNTHESIS OF RACEMIC CHORISMIC ACID AND (‐)‐5‐ENOLPYRUVYLSHIKIMIC ACID (“COMPOUND Z1”) (1983)

Abstract Die beiden Titelverbindungen (XII) und (XVIII) werden ausgehend von den Shikimisäurederivaten (I) (Synthese beschrieben) bzw. (XIII) synthetisiert.
Mechanism(s) of increased vascular cell adhesion on nanostructured poly(lactic‐co‐glycolic acid) films (2005)

Studies have shown that poly(lactic-co-glycolic acid) (PLGA) films with nanometer surface features promote vascular endothelial and smooth muscle cell adhesion. The objective of this in vitro research was to begin to understand the mechanisms behind this observed increase in vascular cell adhesion. Results provided evidence that nanostructured PLGA adsorbed significantly more vitronectin and fibronectin from serum compared to conventional (or those not possessing nanometer surface features) PLGA. When separately preadsorbing both vitronectin and fibronectin, increased vascular smooth muscle and endothelial cell density was observed on nanostructured (compared to conventional) PLGA. Additionally, blocking of cell-binding epitopes of fibronectin and vitronectin significantly decreased vascular cell adhesion on nanostructured (compared to conventional) PLGA. For this reason, results of the present in vitro study demonstrated that cell adhesive proteins adsorbed in different quantities and altered bioactivity on nanostructured compared to conventional PLGA topographies, which (at least in part) may account for the documented increased vascular cell adhesion on nanostructured PLGA. In this manner, this study continues to provide evidence for the promise of nanostructured PLGA in vascular tissue engineering applications.
Effect of Deformation-Induced Heating on the Cold Drawing of Polymeric Films (1991)

The destabilizing effect of deformation-induced heating on the cold drawing of polymeric films is investigated under adiabatic and plane-strain loading conditions. An approximate method, previously devised to study the steady-state cold drawing of polymers with viscoplastic properties, is further modified to incorporate the softening effects due to temperature. Parametric studies are carried out showing the interaction of material properties with the kinematics of the process.
Analysis of business opportunities for tower companies enabled by virtualization (2022)

After describing the modifications introduced in the telecom landscape by the emergence of tower companies (for short, TowerCos), we present potential innovations which can be achieved by enriching towers with edge cloud resources capable of supporting virtualized network functions, notably virtualized Broad Band Units (BBUs) of radio access networks. In particular, we discuss the opportunity of deploying in addition service nodes to host services by service providers in such far edge clouds. This would definitely change the business relationships between TowerCos, network operators and service providers. While this analysis applies mainly to mass market, we discuss how the concept of TowerCo could be extended to B2B market. It turns out that for developing business at the edge of the network, notably requiring local breakout of traffic f1ows, some fundamental principles of the mobile network protocol stack have to be revisited. We also present how an alternative solution based on Magma initially developed by Meta for radio coverage extension could be used in the business of TowerCos for B2C and B2B markets.
Supplemental Figure S7 from ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet–associated Colon Cancer (2023)

&lt;p&gt;Adenomas and adjacent intestinal mucosa from Apc mutant Min mice were probed for pro-TNFÎ±.&lt;/p&gt;
Finite Element Modeling for Optimizing Hermetic Package Reliability (1989)

The thermal stresses in microwave packages are studied by the finite element method. Emphasis is placed on the effects of material construction and design on the reliability of very small hermetic packages. Three different microwave packages have been designed and six finite element models (two for each design) have been analyzed. To verify the validity of the finite element results, some leak tests have been performed and the results agree with the analytical conclusions. The results presented herein should provide a better understanding of the thermal behavior of hermetic packages and should be useful for their optimal design.
Postoperative nitrous oxide analgesia and the functional residual capacity (1983)

Surgery of the upper abdomen is associated with the greatest demand for postoperative analgesia and also is marked by depressed pulmonary function, arterial hypoxemia, and pulmonary complications. Nitrous oxide (N2O) in concentrations of 15-25% is a potent analgesic and is relatively free of untoward side effects if administered for a maximum of 48 h. In the present study, the effect of N2O analgesia on postoperative lung function, in particular, the functional residual capacity (FRC), is examined. Eighteen cholecystectomy patients received either a narcotic (N = 11) or N2O (N = 7) for postoperative analgesia. N2O-treated patients had satisfactory analgesia and maintained FRC at normal levels. Narcotic treated patients had a fall of 22% in FRC. N2O had no effect on the formed elements in peripheral blood.
Mitral valve repair robotic versus sternotomy☆ (2006)

Simple mitral valve repair can be successfully performed with the da Vinci robotic system. This approach is as safe as a sternotomy and long-term follow-up is needed to determine the durability of the mini invasive repair.
Multi-morphology lattices lead to improved plastic energy absorption (2020)

While lattice metamaterials can achieve exceptional energy absorption by tailoring periodically distributed heterogeneous unit cells, relatively little focus has been placed on engineering heterogeneity above the unit-cell level. In this work, the energy-absorption performance of lattice metamaterials with a heterogeneous spatial layout of different unit cell architectures was studied. Such multi-morphology lattices can harness the distinct mechanical properties of different unit cells while being composed out of a single base material. A rational design approach was developed to explore the design space of these lattices, inspiring a non-intuitive design which was evaluated alongside designs based on mixture rules. Fabrication was carried out using two different base materials: 316L stainless steel and Vero White photopolymer. Results show that multi-morphology lattices can be used to achieve higher specific energy absorption than homogeneous lattice metamaterials. Additionally, it is shown that a rational design approach can inspire multi-morphology lattices which exceed rule-of-mixtures expectations.
Role of IL–5 in the Development of Allergen–Induced Airway Hyperresponsiveness (1999)

This review evaluates the role of IL-5 and IL-5-mediated eosinophil airway infiltration in the development of allergen-driven airway hyperresponsiveness. It discusses the structure and function of IL-5 and its receptor and the mechanisms of IL-5-triggered eosinophil accumulation and inflammation of the airways. New research data from murine models of airway inflammation and hyperresponsiveness utilizing different modes of sensitization to allergen and anti-IL-5 antibody or IL-5-deficient knock-out mice underscore the outstanding role of this cytokine in the pathogenesis of bronchial asthma. This review identifies possible directions for future treatment of airway hyperresponsiveness and concludes that targeting IL-5-driven inflammatory responses may be most beneficial for a novel therapy in bronchial asthma.
Improved Hatchability of Turkey Eggs at High Altitudes Due to Added Oxygen and Increased Incubation Temperature (1988)

Turkey egg hatchability at high altitudes was examined at two different oxygen tensions and two incubation temperatures. Incubating turkey eggs in a 149-torr oxygen environment at 37.7 C gave significantly better hatchability than a 109-torr oxygen environment at 37.5 C. Embryonic mortality data indicated that the higher incubation temperature in combination with increased oxygen tension decreased embryonic mortality during the 3rd and 4th wk of incubation and resulted in higher hatchability. The data suggest that hatchery managers at high altitudes should supplement with oxygen and incubate turkey eggs at higher temperatures than employed at lower altitudes.
Cyclic polymers: Advances in their synthesis, properties, and biomedical applications (2020)

Abstract Since the time first synthetic macrocycles were observed as academic curiosities, great advances have been made. Thanks to the development of controlled polymerization processes, new catalytic systems and characterization techniques during the last decades, well‐defined cyclic polymers are now readily accessible. This further permits the determination of their unique set of properties, mainly due to their lack of chain ends, and their use for industrial applications can now be foreshadowed. This review aims to give an overview on the recent progresses in the field of ring polymers to this day. The current state of the art of the preparation of cyclic polymers, the challenges related to it such as the purification of the samples and the scalability of the synthetic processes, the properties arising from the cyclic topology and the potential use of cyclo ‐based polymers for biomedical applications are as many topics covered in this review.
Yeast Hexokinase Inhibitors Designed from the 3-D Enzyme Structure Rebuilding (1997)

This work describes a search for hexokinase inhibitors based on the interactions analysis at the active site of the X-ray resolved o-tolulyl-glucosamine-hexokinase (OTG-HK) complex structure. As the actual enzyme sequence was unknown when the X-ray structure was made (only 30% homology), the structure of the complex was rebuilt by modelling on the X-ray structure frame which allowed residues in close vicinity to the inhibitor to be defined, particularly Glu249 and Gln278. Compounds with inhibitor-bearing groups able to interact with these residues were synthesized and assayed. Some of them revealed strong affinities, in the Km range for glucose. Kinetic analysis of their behaviour towards glucose and ATP together with spectroscopic studies using NMR, allowed the determination of the corresponding inhibition patterns and provided complementary information on HK.
Visually lossless coding based on temporal masking in human vision (2014)

This paper presents a method for perceptual video compression that exploits the phenomenon of backward temporal masking. We present an overview of visual temporal masking and discuss models to identify portions of a video sequences masked due to this phenomenon exhibited by the human visual system. A quantization control model based on the psychophysical model of backward visual temporal masking was developed. We conducted two types of subjective evaluations and demonstrated that the proposed method up to 10% bitrate savings on top of state of the art encoder with visually identical video. The proposed methods were evaluated using HEVC encoder.
Rapid Thermal Annealing of Si+ Implanted GaAs in the Presence of Arsenic Pressure by GaAs Powder (1985)

Rapid thermal annealing of Si + implanted GaAs is carried out using halogen lamps in the presence of arsenic pressure to study the effects of annealing temperature and time on sheet carrier concentration and mobility. The activation efficiency of the implanted layer is primarily affected by the annealing temperature and depends little on the annealing hold time. The surface morphology of GaAs annealed for 30 min at 800°C is smooth, indicating that the presence of arsenic pressure prevents arsenic atoms from evaporating and enables the implanted layer to be annealed for a long time at high temperature without surface dissociation and degradation of electrical properties. The activation energy of implanted Si + in GaAs is found to be 0.53 eV.
Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12. (1994)

Adenovirus early 1 (E1) region gene products, including E1A and E1B, are required for transformation of primary cultured rodent cells. In order to investigate in vivo action of the E1 region, we established a line of transgenic mice carrying the oncogenic E1A and E1B genes of human adenovirus type 12 under control of the human angiotensinogen promoter. Histopathological analyses indicated that transgenic mice heritably develop neuroectodermal tumors arising from the pelvic region with varying degrees of incidence. The transgene was expressed in the neuroectodermal tumors as well as in TNT-1 cells, a cell line established from the tumors, where the human angiotensinogen promoter was constitutively active. The high level expression of c-, L-, and N-myc without gene amplification was notable in the original tumors and TNT-1 cells, but not in another tissue examined. The co-expression of the three sets of myc family genes in both the original tumors and the established cell line provided the possibility that the target cells for transformation may belong to a specific cell type that expresses all these oncogenes during development.
Corrigendum: Quantitative Electrochemical DNA Microarray on a Monolith Electrode with Ten Attomolar Sensitivity, 100 % Specificity, and Zero Background (2020)

Prof. Ravi F. Saraf of this publication discloses financial interest in Vajra Instrument as its Founder and President. In accordance with its Conflict of Interest policy, the University of Nebraska-Lincoln's Conflict of Interest in Research Committee has determined that this must be disclosed. The original manuscript failed to acknowledge that Ravi F. Saraf was affiliated with Vajra Instruments, Inc. or disclose financial interest. The amended Conflict of Interest statement appears below. The authors apologize for this oversight. Prof. Ravi F. Saraf discloses financial interest in Vajra Instrument, Inc. as its Founder and President.
Bulk Metallic Glass with Benchmark Thermoplastic Processability (2007)

Simple microreplication experiments carried out in open air using relatively low applied pressures demonstrate superior thermoplastic processability of newly designed bulk metallic glass. It is the microformed impression of a United States dime coin (see figure) made on the surface of metallic glass wafers at ∼370 °C. This bulk metallic glass exhibits benchmark characteristics of thermoplastic processing and will hopefully broaden the engineering applications of amorphous metals.
ChemInform Abstract: Synthesis of Functionalized Cyclophanes by Ring‐Opening/Ring‐Closure Cascade Reactions of Siloxycyclopropanes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Incipient plasticity of single-crystal tantalum as a function of temperature and orientation (2014)

The nanocontact plastic behaviour of single-crystalline Ta (1 0 0), Ta (1 1 0) and Ta (1 1 1) was studied as a function of temperature and indentation rate. Tantalum, a representative body centred cubic (BCC) metal, reveals a unique deformation behaviour dominated by twinning and the generation of stacking faults. Experiments performed at room temperature exhibit a single pop-in event, while at 200 °C, above the critical temperature, a transition to multiple pop-ins was observed. The experimental results are discussed with respect to the orientation as well as temperature and correlated to the defect structures using both anisotropic finite element and MD simulations. The serrated flow observed at 200 °C is related to differences in the quasi-elastic reloading originating from changes in the defect mechanism.