gebhart/patrepeval huggingface dataset:
Measurement of Iodine-Derived Contamination in L-[<sup>11</sup>C]Methionine Injection (2018)

Measurement methods for iodine-derived contamination in L-[11C]methionine injection were evaluated. L-[11C]Methionine injection and samples from the mock synthesis routes where iodine vapor was introduced with or without passing precolumns of sodium hydroxide-coated silica (Ascarite columns) were used. The contents of total iodine, iodide ion, and I2 were determined by ICP-MS, HPLC-UV detection, and N,N-diethyl-1,4 phenylenediamine method, respectively. Total iodine contents measured by ICP-MS indicated the potentials of Ascarite columns for removing I2 . The iodine-derived contamination existed as iodide ion in the L-[11C]methionine injections. Accordingly, measurement of iodide ion by HPLC offers a rapid and useful means of controlling the manufacturing processes of L-[11C]methionine injection.
Tangent track corrugation model validation with a two disk test rig (2009)

Working alliance has been characterized as an important predictor of positive treatment outcomes. We examined whether illness insight, psychosocial functioning, social support and locus of control were associated with working alliance as perceived by both patient and clinician. We assessed 195 outpatients with psychotic or bipolar disorders. Our findings indicated that patients rated the alliance more positively when they experienced a greater need for treatment, fewer behavioral and social problems, and more psychiatric symptoms. Clinicians rated the alliance more positively in patients who reported fewer social problems and better illness insight. Patients' demographic characteristics, including being female and married, were also positively related to the clinician-rated alliance. Our results suggest that patients and clinicians have divergent perceptions of the alliance. Clinicians may need help developing awareness of the goals and tasks of patients with certain characteristics, i.e., singles, men, those with poor illness insight and those who report poor social functioning.
Cloud of Things for Sensing as a Service: Sensing Resource Discovery and Virtualization (2014)

We propose Cloud of Things for Sensing as a Service: a global architecture that scales up cloud computing by exploiting the global sensing resources of the highly dynamic and growing Internet of Things (IoT) to enable remote sensing. The proposed architecture scales out by augmenting the role of edge computing platforms as cloud agents that discover and virtualize sensing resources of IoT devices. Cloud of Things enables performing in-network distributed processing of sensing data offered by the globally available IoT devices and provides a global platform for meaningful and responsive sensing data analysis and decision making. We design cloud agents algorithmic solutions bearing in mind the onerous to track dynamics of the IoT devices by centralized solutions. First, we propose a distributed sensing resource discovery algorithm based on a gossip policy that selects IoT devices with predefined sensing capabilities as fast as possible. We also propose RADV: a distributed virtualization algorithm that efficiently deploys virtual sensor networks on top of a subset of the selected IoT devices. We show, through analysis and simulations, the potential of the proposed algorithmic solutions to realize virtual sensor networks with minimal physical resources, reduced communication overhead, and low complexity.
Principles and Practice of Intensive Care Monitoring. (1998)

A 35 year old HIV positive patient from Hong Kong presented with a fever, cough and a skin rash in association with a lung mass, all of which were due to disseminated Penicillium marneVei infection. He made a good response to antifungal therapy. The lung mass is a previously undescribed pulmonary manifestation of disseminated Penicillium marneVei infection. Infections with this fungus should be suspected in any patient with HIV and respiratory symptoms who has visited southeast Asia.
Maintaining software with a security perspective (2002)

Testing for software security is a lengthy, complex and costly process. Currently, security testing is done using penetration analysis and formal verification of security kernels. These methods are not complete and are difficult to use. Hence it is essential to focus testing effort in areas that have a greater number of security vulnerabilities to develop secure software as well as meet budget and time constraints. We propose a testing strategy based on a classification of vulnerabilities to develop secure and stable systems. This taxonomy will enable a system testing and maintenance group to understand the distribution of security vulnerabilities and prioritize their testing effort according to the impact the vulnerabilities have on the system. This is based on Landwehr's (1994) classification scheme for security flaws and we evaluated it using a database of 1360 operating system vulnerabilities. This analysis indicates vulnerabilities tend to be focused in relatively few areas and associated with a small number of software engineering issues.
[Occlusion of basilar artery in a 7-year-old boy]. (1990)

A case of occlusion of basilar artery in a boy aged 7 years was reported. Compared with CT, MR imaging was more valuable for the early diagnosis of this disease. SPECT with IMP was thought to be useful in evaluating cerebellar circulation. ABR revealed brain stem abnormalities that could not be detected by neuroradiological techniques.
Serum aldosterone and cortisol concentrations before and after suppression with fludrocortisone in cats (2015)

Primary hyperaldosteronism is an increasingly recognized syndrome in cats, and diagnosis can be difficult. A potential diagnostic method has been reported, utilizing oral fludrocortisone administered twice daily for 4 days followed by collection of urine. In the current study, we sought to determine if blood sampling and a shorter dosing period would provide a possible means to test for primary hyperaldosteronism. Also, cortisol concentrations were measured to assess the potential of fludrocortisone to act as a glucocorticoid in cats. In phase I, 8 healthy laboratory cats were studied in a placebo-controlled, crossover design. Serum aldosterone and cortisol concentrations were measured before and on the second, third, and fourth day of treatment and compared within groups. In phase II, based on the results obtained in phase I, 8 healthy client-owned cats were administered 3 doses of fludrocortisone or placebo. Serum aldosterone and cortisol concentrations were compared before and after treatment within groups. In both phases, serum aldosterone and cortisol concentrations were significantly suppressed in fludrocortisone-treated cats. Thus, it was determined that oral administration of fludrocortisone causes suppression of serum aldosterone in healthy adult cats after only 3 doses. Further research is needed to determine the effects of oral fludrocortisone in cats with primary hyperaldosteronism and cats with other disorders causing hypertension and/or hypokalemia to determine if this protocol can be used as a tool for the definitive diagnosis of primary hyperaldosteronism.
Hepatitis B and C Co-Infection Are Independent Predictors of Progressive Kidney Disease in HIV-Positive, Antiretroviral-Treated Adults (2012)

ClinicalTrials.gov NCT00027352; NCT00004978.
ISOLATION AND CHARACTERIZATION OF FREE FORM PROSTATE SPECIFIC ANTIGEN (f-PSA) IN SERA OF MEN WITH PROSTATE CANCER (1997)

In our preliminary experiment, the free form of serum PSA is partially isolated directly from human sera. Amino terminal sequence analysis has shown that serum f-PSA is not a pre-mature or zymogen form of PSA because serum f-PSA has a N-terminus identical to that of seminal fluid PSA. A nicked form of f-PSA is also found in these patient sera.
AT and T OETC Quarterly Technical Report for July - September 1992 (1992)

The activities of July-September 1992 have primarily revolved around planning the AT and T portion of the OETC program, interacting with IBM and GE concerning piecepart supply and system use of the transmitters, receivers, and connectors that AT and T is fabricating, and in transmitter, receiver, and connector design.
A CMOS BEOL accelerometer low-noise readout amplifier with 4.2 zF/√Hz total noise floor (2015)

This article describes a low-noise readout amplifier for a post-CMOS BEOL (Back End Of Line) surface micromachining capacitive accelerometer. Simulations show 300.0 zF/√Hz acceleration and 4.2 zF/√Hz capacitance noise floors while chopping at 1 MHz and having a power consumption of 1.38 mW. The performed noise minimization is described, comprising input transistor pair type election, optimum input pair inversion region and dimensions using an all-region EKV model and equations describing parasitics and loop characteristics of the circuit. Simulations have been included that verify the theoretical model accuracy and demonstrate final circuit noise performance. The circuit layout has been taped out and testchip availability is expected soon for experimental measurements.
AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer (2020)

AMG 757 has a compelling safety and efficacy profile in preclinical studies making it a viable option for targeting DLL3-expressing SCLC tumors in the clinical setting.
Transmission power adaptation for cognitive radios (2012)

In cognitive radio (CR) networks, determining the optimal transmission power for the secondary users (SU) is crucial to achieving the goal of maximizing the secondary throughput while protecting the primary users (PU) from service disruption and interference. In this paper, we propose an adaptive transmission power scheme for cognitive terminals opportunistically accessing a primary channel. The PU operates over the channel in an unslotted manner switching activity at random times. The secondary transmitter (STx) adapts its transmission power according to its belief regarding the PU's state of activity. The objective is to maximize a utility function that is related to the secondary throughput. The function has also a term that penalizes collision with the PU. We quantify and demonstrate, via numerical simulations, the enhanced CR system performance relative to fixed transmission power operation.
Cystamine-Sepharose. A probe for the active site of gamma-glutamylcysteine synthetase. (1982)

gamma-Glutamylcysteine synthetase, previously known to be potently inhibited by cystamine, has been found to bind covalently to cystamine-Sepharose. ATP facilitates, whereas glutamate plus magnesium ions inhibit, binding of the enzyme to cystamine-Sepharose. A large fraction of the enzyme applied to columns of cystamine-Sepharose binds by forming a disulfide bond between cysteamine-Sepharose and a sulfhydryl group at or near the active site of the enzyme. The enzyme may be released by treatment with dithiothreitol. Some of the enzyme applied to such columns is inactivated and not bound covalently to the column. That the enzyme does not bind to columns of S-(S-methyl)cysteamine-Sepharose, whereas free S-(S-methyl)cysteamine is a potent inhibitor, indicates that a cysteamine-S disulfide moiety derived from the external cysteamine residue of cystamine-Sepharose is the critical group recognized by the enzyme. The observed partitioning of the enzyme on columns of cystamine-Sepharose between covalently column-bound enzyme and nonbound inactivated enzyme suggests that the reactive enzyme sulfhydryl group forms a disulfide linkage with the sulfur atom at the immobilized end of cystamine to link the enzyme to the column and to liberate free cysteamine, and also that the enzyme interacts with the external cysteamine moiety of the bound cystamine. The latter may occur if the free cysteamine released is spontaneously oxidized to free cystamine followed by its inhibition of the enzyme, or if there is a direct reaction between the enzyme-reactive sulfhydryl group and the sulfur atom of the external cysteamine moiety of cystamine-Sepharose.
QoS-Aware Sum Capacity Maximization for Mobile Internet of Things Devices Served by UAVs (2022)

The use of unmanned aerial vehicles (UAVs) acting as flying base stations (FlyBSs) is considered as an effective tool to improve performance of the mobile networks. Nevertheless, such potential improvement requires an efficient positioning of the FlyBS. In this paper, we maximize the sum downlink capacity of the mobile Internet of Things devices (IoTD) served by the FlyBSs while a minimum required capacity to every device is guaranteed. To this end, we propose a geometrical approach allowing to derive the 3D positions of the FlyBS over time as the IoTDs move and we determine the transmission power allocation for the IoTDs. The problem is formulated and solved under practical constraints on the FlyBS's transmission and propulsion power consumption as well as on flying speed. The proposed solution is of a low complexity and increases the sum capacity by 15%-46% comparing to state-of-the-art works.
Embolotherapy for the giant porto-systemic shunt. Usefullness of the dual balloon occluded embolotherapy. (1994)

巨大門脈-大循環短絡(X線フィルム上の短絡口径10mm以上)8例を対象にIVRの手技を用いた塞栓術を施行し,治療成績,合併症,予後から塞栓術式,適応に検討を加えた.同時性バルーン閉鎖下塞栓術は流入路のみからの経回結腸静脈塞栓術と流出路のみからのバルーン下逆行性静脈的塞栓術を合わせ改良工夫した方法である.従来法に比して侵襲度が高く,手技も煩雑であるが,P-S短絡に基づく難治性食道・胃静脈瘤,肝性脳症に対して即効性,持続性であり安全,確実な治療法である.適応決定にはバルーン閉鎖試験が良い指標で,Child A,B,門脈圧増加率60%以下が施行安全域の目安となる.手技上の要点は短絡閉鎖後遠肝路としての発達が予測される静脈と複数個の流入路を単一化する予防塞栓術が大切で,複雑な静脈の細吻合形式である食道静脈瘤の内視鏡上の消失率が未だ不十分なこと,術前に閉鎖後門脈圧増加を予測する正確な手段が無いことが問題点として提起された.
Temporal Relationship between Cardiac Myosin-Binding Protein C and Cardiac Troponin I in Type 1 Myocardial Infarction (2016)

tes, partly because of lack of standardization between immunoassay platforms (3 ). Assay standardization awaits well-characterized reference materials (4 ) becoming widely available. In the interim, independent quantitative AAA may have general utility in the characterization of peptides used to develop candidate reference methods (5 ).
Useful Definitions and Mathematical Results (2014)

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Does Organizational Innovation Capability Impact Electronic Medical Records Implementation Success (2019)

Innovation capability involves the bringing to the market and/or successful implementation of a new product or service. It is the ability to mobilize the knowledge of the employees and the organization from past experiences to create new knowledge, and use such new knowledge to bring to the market and/or successfully implement a new product or service. Innovation capability is associated with higher levels of product and process innovation within the organization. EMR is considered a technology innovation per research literature. In this research-in-progress paper, we posit that an organization with a high level of innovation capability based on product and process innovation implementations in the past will successfully implement a technology innovation such as an EMR system. A conceptual model is presented with related hypotheses.
NFIRAOS beamsplitters subsystems optomechanical design (2016)

The early-light facility adaptive optics system for the Thirty Meter Telescope (TMT) is the Narrow-Field InfraRed Adaptive Optics System (NFIRAOS). The science beam splitter changer mechanism and the visible light beam splitter are subsystems of NFIRAOS. This paper presents the opto-mechanical design of the NFIRAOS beam splitters subsystems (NBS). In addition to the modal and the structural analyses, the beam splitters surface deformations are computed considering the environmental constraints during operation. Surface deformations are fit to Zernike polynomials using SigFit software. Rigid body motion as well as residual RMS and peak-to-valley surface deformations are calculated. Finally, deformed surfaces are exported to Zemax to evaluate the transmitted and reflected wave front error. The simulation results of this integrated opto-mechanical analysis have shown compliance with all optical requirements.
Effects of pulse width, timing jitter and wavelength detuning of the control pulse in switching solitons using the nonlinear optical loop mirror configuration (1997)

In this paper, we investigate numerically the effects of the various parameters of the control pulse on an all-optical controlled switching configuration, using a nonlinear optical loop mirror (NOLM) to switch solitons. The peak switching power of the control pulse required to achieve maximum switching efficiency was found to decrease as the width of the control pulse was increased. It is also shown that, due to the Raman effect, more than 100% of maximum switching efficiency of a NOLM can be achieved. Furthermore, when the control pulse width is equal to three times the signal pulse width, a switching efficiency of more than 90% could still be obtained even when the central wavelength of the control pulse is detuned by about 4 nm or when timing jitter is more than 1.5 times the signal pulse width.
Conformal coating of amorphous silicon and germanium by high pressure chemical vapor deposition for photovoltaic fabrics (2018)

Conformally coating textured, high surface area substrates with high quality semiconductors is challenging. Here, we show that a high pressure chemical vapor deposition process can be employed to conformally coat the individual fibers of several types of flexible fabrics (cotton, carbon, steel) with electronically or optoelectronically active materials. The high pressure (∼30 MPa) significantly increases the deposition rate at low temperatures. As a result, it becomes possible to deposit technologically important hydrogenated amorphous silicon (a-Si:H) from silane by a simple and very practical pyrolysis process without the use of plasma, photochemical, hot-wire, or other forms of activation. By confining gas phase reactions in microscale reactors, we show that the formation of undesired particles is inhibited within the microscale spaces between the individual wires in the fabric structures. Such a conformal coating approach enables the direct fabrication of hydrogenated amorphous silicon-based Schottky junction devices on a stainless steel fabric functioning as a solar fabric.
Mutationen im CFTR-Gen führen unabhängig von einer direkten Wirkung auf die Azinuszelle zu einem schwereren Verlauf der Pankreatitis (2009)

Rezidivierende Pankreatitiden werden in 1–2% der pankreassuffizienten Patienten mit Mutationen im CFTR-Gen beobachtet. Im Vergleich zur Normalbevölkerung weisen Patienten mit idiopathischer Pankreatitis mit einer Häufigkeit von 16,7–25,9% Mutationen im CFTR Gen auf. Die pathophysiologischen Mechanismen, die für diese Assoziation verantwortlich sind, sind bisher unverstanden. Wir haben den Verlauf der akuten Pankreatitis an für das CFTR-Gen mutierten Mäusen untersucht.
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models (2021)

Abstract Vaccines against SARS-CoV-2 are urgently required. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 reduced both virus shedding and lung pathology. Antibody titers were boosted by a second dose. Data from these challenge models and the detailed immune profiling, support the continued clinical evaluation of ChAdOx1 nCoV-19.
Perceptually tuned generation of grayscale fonts (1995)

A new approach to grayscale font generation improves on the fuzzy characters produced by existing methods by incorporating the expertise of type designers into rules for character-outline weight and phase control. The method we propose for synthesizing high-contrast grayscale characters relies on the set of visual rules that type designers have derived from their many years of manual design. We call our grayscaling method 'perceptually tuned font generation', because it is based on human perception-that of both the designer and the reader.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Proposal for electron spin relaxation measurements using double-donor excited states in Si quantum computer architectures (2007)

The possibility of performing single-spin measurements in Si-based quantum computers using electrons bound to double donors near a barrier interface is assessed. We find that double donors in the ground state require electric fields and tunneling times too large for practical implementations, while operations with double donors in their first excited state involve smaller fields and faster tunneling times, and are therefore suitable for spin-to-charge conversion measurements. We propose a measurement scheme that would render ensemble estimates of the spin coherence at the $\mathrm{Si}∕\mathrm{Si}{\mathrm{O}}_{2}$ interface.
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy (2023)

Hippocampal somatic variants, particularly those activating Ras/Raf/MAPK signaling, may contribute to the pathogenesis of sporadic, drug-resistant MTLE. These findings may provide a novel genetic mechanism and highlight new therapeutic targets for this common indication for epilepsy surgery.
Critical Oligomer Degree of Polymerization for Irreversible Entry (2016)

A large group of industrially important polymerization processes is carried out in dispersed systems. These processes differ with respect to their physical nature, mechanism of particle formation, particle morphology, size, charge, types of interparticle interactions, and many other aspects. Polymer dispersions, and polymers derived from polymerization in dispersed systems, are used in diverse areas such as paints, adhesives, microelectronics, medicine, cosmetics, biotechnology, and others. Frequently, the same names are used for different processes and products or different names are used for the same processes and products. The document contains a list of recommended terms and definitions necessary for the unambiguous description of processes, products, parameters, and characteristic features relevant to polymers in dispersed systems.
Carbohydrate‐Deficient Transferrin as a Measure of Immoderate Drinking: Remaining Issues (1994)

A growing body of investigations demonstrate that elevated levels of carbohydrate-deficient transferrin (CDT) effectively distinguishes alcoholics recently consuming large amounts of alcohol from light social drinkers or teetotalers. Nevertheless, important questions still remain concerning the value of CDT as a more generalized marker of alcohol consumption. Most important, the nature of the drinking pattern, including quantity and frequency, necessary to raise levels of CDT significantly remains unclear. Neither has research convincingly demonstrated that CDT is as accurate a marker for women, young adults, or non-Caucasian ethnic groups as for White, middle-aged men. Whereas CDT might serve as a useful outcome measure in trials of alcoholism treatment effectiveness, current research suggests that CDT is of limited value in identifying problematic drinking in general medical or community settings in which a broad continuum of drinkers is represented. Combining CDT with other biochemical or self-report screening measures may, however, improve sensitivity in these contexts. At present, the most accurate laboratory technique to detect CDT seems to be isoelectric focusing. Additional research, however, is needed to resolve the issue of whether CDT is best quantitated as a simple value or if its ratio to total transferrin or non-CDT results in higher predictive validity.