gebhart/patrepeval huggingface dataset:
Raised saturated-fat intake worsens vascular function in virgin and pregnant offspring of streptozotocin-diabetic rats (2000)

Adult offspring of severely diabetic pregnant rats are insulin resistant and display cardiovascular dysfunction. When pregnant they develop mild hyperglycaemia. Diets high in saturated fat have been implicated in the development of cardiovascular disease and vascular dysfunction. In the present study we have determined vascular function in small mesenteric arteries from offspring of normal (OC) and diabetic (OD) rats fed standard chow and offspring of diabetic rats fed a diet high in saturated fats (OD-HF) from weaning to adulthood, and throughout their subsequent pregnancies. OD rats displayed an increased sensitivity to noradrenaline (P < 0.05) and impaired sensitivity to the endothelium-dependent vasodilator, acetylcholine. The component of acetylcholine-induced relaxation attributable to endothelium-derived hyperpolarizing factor was reduced in OD-HF rats. Pregnant OD rats also demonstrated impaired maximum relaxation to acetylcholine (pregnant OD rats v. pregnant OC rats P < 0.05). In pregnant OD-HF rats noradrenaline sensitivity was enhanced and endothelium-dependent relaxation further reduced (pregnant OD-HF rats v. pregnant OC rats P < 0.001). The isoprostane, 8-epi-prostaglandin F2alpha, a marker of oxidative stress, was increased in pregnant OD rats (pregnant OD rats v. pregnant OC rats P
A Possible Mechanism for Decrease in Serum Thyroxine Level by Polychlorinated Biphenyls in Wistar and Gunn Rats (2004)

We have previously demonstrated that in mice, the decrease in serum thyroxine (T(4)) level by polychlorinated biphenyls (PCBs) occurs without an increase in the UDP-glucuronosyltransferase (T(4)-UDP-GT) for T(4) glucuronidation, although the PCB-induced decrease in rats is generally thought to occur through induction of T(4)-UDP-GT, UGT1A1, and UGT1A6. In the present study, to further clarify the relationship between the decrease in serum T(4) level and the increase in UGT1A activity by PCB in rats, we examined the relationship using Wistar rats and Gunn rats, a mutant strain of Wistar rats deficient in UGT1A isoforms. The serum total T(4) level was markedly decreased not only in the Wistar rats but also in the Gunn rats 4 days after treatment with a PCB, Kanechlor-500 (KC500, 100 mg/kg) or 2,2',4,5,5'-pentachlorobiphenyl (PentaCB, 112 mg/kg), and there was no significant difference in magnitude of the decrease between the two rat strains. At the same time, the level and activity of T(4)-UDP-GT were significantly increased by treatment with either KC500 or PentaCB in Wistar rats but not in Gunn rats. In addition, no significant change in the level of serum total triiodothyronine (T(3)) and thyroid-stimulating hormone by the KC500 treatment was observed in either Wistar or Gunn rats. Furthermore, significant decrease in the activity of hepatic type-I deiodinase, which mediates the deiodization of T(4) and T(3), by treatment with KC500 or PentaCB was observed in both Wistar and Gunn rats. From the serum of KC500- or PentaCB-treated Wistar and Gunn rats, mono- and di-hydroxylated PCB metabolites, which would bind to T(4) binding serum protein (transthyretin), were detected. In conclusion, the present results suggest that the decrease in serum total T(4) level by either KC500 or PentaCB in Gunn rats was not dependent on the increase in hepatic T(4)-UDP-GT activity. The findings further suggest that the PCB-mediated decrease in serum T(4) level might occur, at least in part, through formation of the hydroxylated PCB metabolites. Furthermore, even in Wistar rats, the PCB-mediated decrease in serum T(4) level might occur not only through the increase in hepatic T(4)-UDP-GT but also via formation of hydroxylated PCB metabolites.
Galanin reduces PDBu‐induced protein phosphorylation in rat ventral hippocampus (1992)

The effect of galanin (GAL) on basal and phorbol-12,13-dibutyrate (PDBu) induced protein phosphorylation in rat ventral hippocampal miniprisms was investigated. GAL (0.5, 1 and 2 microM) inhibited PDBu stimulation in a concentration-dependent manner without altering basal protein phosphorylation. This inhibitory effect was prevented by the GAL antagonist galantide. GAL did not affect either the activity of protein kinase C (PKC) from rat brain or basal phosphorylation in ventral hippocampal hippogenates, suggesting that it did not directly modulate PKC activity. Depolarization of miniprisms from ventral hippocampi by 18 mM K+ prevented the effect of GAL on PDBu-induced phosphorylation. The results indicate that GAL indirectly regulates neuronal protein phosphorylation by a GAL receptor-mediated action.
A survey of leakage-resilient cryptography (2019)

research-article Share on A survey of leakage-resilient cryptography Authors: Yael Tauman Kalai View Profile , Leonid Reyzin View Profile Authors Info & Claims Providing Sound Foundations for Cryptography: On the Work of Shafi Goldwasser and Silvio MicaliOctober 2019 Pages 727–794https://doi.org/10.1145/3335741.3335768Published:04 October 2019Publication History 20citation149DownloadsMetricsTotal Citations20Total Downloads149Last 12 Months17Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Figure S3 from Identification of <i>Pik3ca</i> Mutation as a Genetic Driver of Prostate Cancer That Cooperates with <i>Pten</i> Loss to Accelerate Progression and Castration-Resistant Growth (2023)

&lt;p&gt;Supplementary Figure 3: Characterization of Pik3ca-mutated and Pten-deleted prostate hyperplasia and carcinoma. (A) IHC to detect the apoptotic marker Cleaved-Caspase-3 (CC3) in Wt, Pik3ca+/HR and Ptenfl/fl mice at 400 d (scale bar: 50 um). (B) Quantitation of CC3-positive nuclei in Wt, Pik3ca+/HR and Ptenfl/fl prostate epithelium (n = 3, *P &lt;0.05 compared to Wt, or as indicated, one-way ANOVA with Tukey's multiple comparison test, ns = not significant. Error bars: SEM). (C) IHC to detect CK5 and CK8 in Pik3ca+/HR and Ptenfl/fl carcinomas (representative images from 3 prostates per genotype, scale bar: 50 um). (D) Representative IHC images to detect PTEN, mTORC1 signaling components (p-AKT Thr308, p-RPS6 Ser235/236 and p-4E-BP1 Thr37/46) and mTORC2 substrates (p-AKT Ser473 and p-NDRG1 Thr346) in Pik3ca+/HR and Ptenfl/fl hyperplastic lesions (n = 3, scale bar: 50 um). IHC quantitation for (E) p-AKT Thr308, (F) p-RPS6 Ser235/236, (G) p-4E-BP1 Thr37/46, (H) p-AKT Ser473 and (I) p-NDRG1 Thr346 in Pik3ca+/HR and Ptenfl/fl prostate hyperplastic lesions (n = 3, Error bars: SEM, *P &lt; 0.05, unpaired, two-tailed t-test).&lt;/p&gt;
Environmental pH modulates transcriptomic responses in the fungus Fusarium sp. associated with KSHB Euwallacea sp. near fornicatus (2018)

We identified transcripts related to pH signaling such as the conserved PAL/RIM pathway, some transcripts related to secondary metabolism and other transcripts that were differentially expressed. Our analysis suggests possible mechanisms involved in pathogenicity in this novel Fusarium species. This is the first report that shows transcriptomic data of this pathogen as well as the first report of genes and proteins involved in their metabolism identifying potential virulence factors.
Chemoresistance of Endothelial Cells Induced by Basic Fibroblast Growth Factor Depends on Raf-1–Mediated Inhibition of the Proapoptotic Kinase, ASK1 (2007)

Genotoxic stress induced by anticancer drugs can lead to apoptosis of both angiogenic endothelial cells (ECs) and proliferating tumor cells. However, growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor (VEGF) present within the tumor microenvironment can promote chemoresistance by suppressing apoptotic mechanisms in these cells. Here, we have identified apoptosis signal-regulating kinase 1 (ASK1), a proapoptotic member of the MAP3K family, as a target of bFGF-mediated survival signaling in ECs. Evidence is provided that ASK1 is required for EC apoptosis in response to the genotoxic chemotherapeutic agent doxorubicin, and that bFGF, but not VEGF, neutralizes the death-promoting activity of ASK1. Specifically, bFGF stimulation promotes the formation of a Raf-1/ASK1 complex at the mitochondria, inhibits ASK1 kinase activity, and protects ECs from genotoxic stress. Mutation of the Raf-1 activation domain (SS338/9AA) not only prevents Raf-1/ASK1 complex formation but abolishes bFGF-mediated EC protection from genotoxic stress. In line with these observations, bFGF, but not VEGF, neutralizes the antiangiogenic effects of doxorubicin in vivo. These findings reveal a new pathway of EC survival signaling and define a molecular mechanism for chemoresistance induced by bFGF.
Podiform chromitite-bearing ultrabasic rocks from the Bragança Massif, northern Portugal: fragments of island arc mantle? (1995)

Abstract The Upper Allochthonous Thrust Complex (UATC) of the Bragança massif in northern Portugal contains a set of ultrabasic rocks interthrust with granulites. The ultrabasic rocks have refractory silicate mineral and whole rock compositions which indicate an origin as depleted mantle. Phase relationships of harzburgite samples suggest that they formed in equilibrium with high-Mg picritic melts created through a high degree of mantle partial melt extraction. Chromite in small podiform deposits has 100 Cr/(Cr + Al) ratios of 62–85, which are consistent with crystallization from such melts. Most of the chromite composition parameters are similar to those of ophiolite deposits except for the high ferric iron contents (2.77–8.95 wt% Fe 2 O 3 ). Such enrichment is a feature of chromite from island arc magmas. It is suggested that the extensive partial melt extraction and chromite mineralization in the ultrabasic rocks occurred in the upper few kilometres of island arc mantle. The ultrabasic rocks were tectonically emplaced into a granulite and eclogite-bearing arc-continent collision complex during the Early Ordovician and subsequently, in the mid-Devonian emplaced over the Central-Iberian terrane.
ARROW – steps towards resolving the ‘orphan works problem’ (2010)

Serials: The Journal for the Serials Community has been digitised and can be accessed in full on this website. All content is freely available on an open-access basis. Serials was published between 1988 and 2011. In 2012, the journal was retitled and is now published as Insights: the UKSG journal.
Automatic Tuning of High Piano Tones (2020)

Piano tuning is known to be difficult because the stiffness of piano strings causes the tones produced to be inharmonic. Aural tuning is time consuming and requires the help of a professional. This motivates the question of whether this process can be automated. Attempts at automatic tuning are usually assessed by comparing the Railsback curve of the results with the curve of a professional tuner. In this paper we determine a simple and reliable rule for tuning the high tones of a piano with the help of a listening test. This rule consists of matching the two tones in an octave interval so that the first partial frequency of the upper tone becomes exactly the same as the second partial frequency of the lower tone. This rule was rated best among four tuning rules that were compared in the test. The results found are explained using a beat-based analysis, and are consistent with some previous studies. They are also tested against the existing method of using Railsback curves, and it is shown that comparison using Railsback curves is an unreliable method of assessing different tunings. The findings from this paper can be used to create a complete automatic tuner that could make the process of piano tuning quick and inexpensive.
Operations of the Pierre Auger Observatory (2021)

The construction of the first stage of the Pierre Auger Observatory, designed for research of ultra-high energy cosmic rays, began in 2001 with a prototype system. The Observatory has been collecting data since early 2004 and was completed in 2008. The Observatory is situated at 1400 m above sea level near Malargüe, (Mendoza province) in western Argentina, covering a vast plain of 3000 squared km, known as the Pampa Amarillo. The Observatory consists of a hybrid detector, in which there are 1660 water-Cherenkov stations, forming the Surface Detector (SD) and 27 peripheral atmospheric fluorescence telescopes, comprising the Fluorescence Detector (FD).Over time, the Auger Observatory has been enhanced with different R&D prototypes and is recently being to an important upgrade called AugerPrime. In the present contribution, the general operations of the SD and FD will be described. In particular the FD shift procedure - executable locally in Malargüe or remotely by teams in control rooms abroad within the Collaboration - and the newly SD shifts (operating since 2019) will be explained. Additionally, the SD and FD maintenance campaigns, as well as the data taking and data handling at a basic level, will be reported
Optimizing Memory Placement using Evolutionary Graph Reinforcement Learning (2020)

For deep neural network accelerators, memory movement is both energetically expensive and can bound computation. Therefore, optimal mapping of tensors to memory hierarchies is critical to performance. The growing complexity of neural networks calls for automated memory mapping instead of manual heuristic approaches; yet the search space of neural network computational graphs have previously been prohibitively large. We introduce Evolutionary Graph Reinforcement Learning (EGRL), a method designed for large search spaces, that combines graph neural networks, reinforcement learning, and evolutionary search. A set of fast, stateless policies guide the evolutionary search to improve its sample-efficiency. We train and validate our approach directly on the Intel NNP-I chip for inference. EGRL outperforms policy-gradient, evolutionary search and dynamic programming baselines on BERT, ResNet-101 and ResNet-50. We additionally achieve 28-78\% speed-up compared to the native NNP-I compiler on all three workloads.
Quantification of Cysteine Oxidation in Human Estrogen Receptor by Mass Spectrometry (2007)

Redox-dependent modifications of sulfhydryl groups within the two Cys4 zinc fingers of the estrogen receptor DNA-binding domain (ER-DBD) result in structural damage and loss of ER DNA-binding function, which parallels the situation observed in many ER-positive breast cancers. Quantitation of the redox status of cysteinyl thiols within ER-DBD employed cysteine-specific oxidants to induce varying degrees of oxidation in recombinant ER, followed by differential alkylation with the stable isotopic labeling reagents [12C2]-iodoacetic acid and [13C2]-bromoacetic acid. Subsequent proteolysis with LysC/Asp-N generated diagnostic peptides of which the C-terminal peptide of the second zinc finger is most strongly detected by mass spectrometry (MS) and serves as a suitable marker of ER-DBD redox status. Data were collected from two different MALDI-MS instruments: a time-of-flight and a linear ion trap (vMALDI-LIT). An analogous but larger synthetic peptide treated with three isotopic variants of the alkylating reagent modeled isotopic overlaps that might complicate the relative quantitation of cysteine oxidation. Despite the isotopic overlaps, excellent relative quantitation was achieved from MS data obtained from both instruments. This was also true of tandem MS/MS data from the vMALDI-LIT, which should facilitate selected reaction monitoring. Relative quantitation by MS also closely matched data from immunochemical methods.
Structural stabilization of DNA-templated nanostructures: crosslinking with 2,5-bis(2-thienyl)pyrrole monomers (2012)

Ordered 2,5-bis(2-thienyl)pyrrole (SNS) zipper arrays are formed by hybridization of complementary DNA oligomers each containing covalently bound SNS monomers. Upon oxidation with HRP/H2O2, these SNS arrays are converted to oligomers having specific lengths and conformation. As a consequence of this reaction the two SNS-containing strands are permanently crosslinked.
150 Mbit/s phase diversity ASK homodyne receiver with a linewidth/bit rate ratio of 0.5 (1988)

A 150 Mbit/s ASK phase-diversity homodyne receiver was constructed with a DFB laser emitting at 1550 nm. At a BER of 10−9, a sensitivity of −55 dBm, corresponding to 77 photoelectrons/bit, was measured.
Experiments in optimal control of a flexible arm (1985)

©1985 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
The Australian National Standards Laboratory X-Band Radiometer for the Calibration of Noise Sources (1968)

The chief possible causes of error in the calibration of microwave noise sources are examined and a radiometer designed to minimize these errors is described. This includes a self-contained hot-load standard, facilities for measuring the hot-guide losses, a synchronously switched broad-band circulator, a switchable, high-stability attenuator, provision for measuring this attenuation, and a carbon-filament lamp reference noise source.
Efficiency improvement of power conversion system with multilayer power inductor (2020)

In this paper, the multilayer power inductor with the air-clip is designed and fabricated to improve the saturation current of power inductor for the power conversion system. It is proved that the air-clip is able to influence the saturation current of power inductor and the efficiency of the power conversion system. Also, the possibility of the power inductor with the air-clip in the power conversion system for improving rated current and efficiency is demonstrated.
The structures of the novel protein kinase C inhibitors K-252a, b, c and d. (1986)

The structures of four new protein kinase C inhibitors of microbial origin, K-252a, b, c and d were determined by spectral studies and chemical conversion.
Transcriptional analyses of the uncoordinated region of Drosophila melanogaster (1990)

RNA blotting experiments reveal that a genomic region encompassing the uncoordinated complementation group of Drosophila melanogaster produces two classes of transcripts. The first class contains five polyadenylated RNAs, of 4.35, 8.7, 9.0, 11.5, and 13.0 kb, and the second class contains a transcript of 7.3 kb that can be detected in both the total cellular and the poly(A)+ fractions. Transcripts of the first class are found predominantly in the early larval, pupal, and adult life stages, whereas the 7.3-kb species is present throughout the life cycle and is also found in the heads of adult flies. The two classes of RNAs derive from different combinations of exons. Analyses of RNAs derived from genotypes that are deficient for the uncoordinated complementation group and from seven uncoordinated mutant alleles support the suggestion that the uncoordinated gene (unc) has been isolated and encodes the multiple transcripts.
Dissecting neural circuitry that regulates energy balance (2013)

The control of food intake requires neural and hormonal signals between the gut and the central nervous system, forming a “gut-brain” axis. Cholecystokinin (CCK) is a gut hormone that signals via vagal afferents to the brain to terminate a meal. Previous studies from our lab have demonstrated that central signalling by the neuropeptide, prolactin-releasing peptide (PrRP), is required for CCK-induced satiety. Animals that lack the PrRP receptor do not respond to CCK. PrRP is expressed in areas involved in body-weight regulation in the hypothalamus and brainstem. Using the Cre-LoxP system in transgenic mice, we dissected separate populations of hypothalamic and brainstem PrRP neuron to assess their roles in mediating the effects of CCK. LSL-PrRP mice, with a loxSTOPlox codon between the PrRP promoter and coding sequence, do not express PrRP, are obese and do not respond to CCK. However, Cre-mediated rescue of brainstem PrRP expression prevents obesity and restores the anorectic feeding response to CCK. Together, these results demonstrate that PrRP expression in the brainstem, not the hypothalamus, is sufficient to mediate the effects of CCK and affect overall body weight. Thus, the CCK-PrRP pathway is a major component of the gut-brain axis and is a potential target in the development of novel treatments for obesity.
Stereospezifische Einschiebung von Acetylenen in die PH‐Bindung von C5H5(CO)2MnP(Ph)H2 (1977)

Abstract Dicarbonyl(cyclopentadienyl)(phenylphosphin)mangan, C 5 H 5 (CO) 2 MnP(Ph)H 2 (1), läßt sich mit Acetylenen zu Phenylvinylphosphin‐Komplexen 2 , umsetzen. Die Einschiebung der Acetylene erfolgt stereospezifisch: Mit Phenylacetylen entsteht durch trans ‐Addition ausschließlich C 5 H 5 (CO) 2 MnP(Ph)(H)CHC(H)Ph ( 2a ), in dem die Phenylgruppe und das Phosphoratom cis ‐ständig an die Vinylgruppe gebunden sind. Mit Diphenylacetylen bildet sich C 5 H 5 (CO) 2 ‐MnP(Ph)(H)C(Ph)C(H)Ph ( 2b ), das, nach den Ergebnissen einer Röntgenstrukturanalyse, eine trans ‐Diphenylvinyl‐Gruppierung enthält. Das Dialkin Me 2 Si(CCH) 2 setzt sich mit 1 beim Kochen in THF unter Einschiebung nur einer Alkin‐Gruppierung zu C 5 H 5 (CO) 2 MnP‐(Ph)(H)C(H)C(H)SiMe 2 CCH (2c) um. Ein Ringschluß unter Einbeziehung der zweiten Alkin‐Gruppierung wird unter diesen Bedingungen nicht beobachtet.
Implementation and Performance Evaluation of nanoMAC: A Low-Power MAC Solution for High Density Wireless Sensor Networks (2006)

This paper describes the implementation architecture and performance analysis of nanoMAC, a CSMA/CA based medium access control protocol, which is specifically designed for high density wireless sensor networks. We empirically show that nanoMAC performs with high reliability in a variety of network traffic conditions in single and multihop scenarios. For energy efficient operation and minimizing idle-overhearing, nanoMAC uses a specialized sleep algorithmWe also show results from a comparative study of nanoMAC with B-MAC in terms of performance measures.
δ-Catenin Regulates Spine and Synapse Morphogenesis and Function in Hippocampal Neurons during Development (2009)

The maintenance of spine and synapse number during development is critical for neuronal circuit formation and function. Here we show that delta-catenin, a component of the cadherin-catenin cell adhesion complex, regulates spine and synapse morphogenesis during development. Genetic ablation or acute knockdown of delta-catenin leads to increases in spine and synapse density, accompanied by a decrease in tetrodotoxin induced spine plasticity. Our results indicate that delta-catenin may mediate conversion of activity-dependent signals to morphological spine plasticity. The functional role of delta-catenin in regulating spine density does not require binding to cadherins, but does require interactions with PDZ domain-containing proteins. We propose that the perturbations in spine and synaptic structure and function observed after depletion of delta-catenin during development may contribute to functional alterations in neural circuitry, the cognitive deficits observed in mutant mice, and the mental retardation pathology of Cri-du-chat syndrome.