gebhart/patrepeval huggingface dataset:
Structural features and restricted expression of a human α-tubulin gene (1985)

The nucleotide sequence of a human alpha-tubulin gene (b alpha 1) is described. This gene is extensively homologous to a rat alpha-tubulin gene in its coding regions, 3'-untranslated region and, indeed, in segments of its largest intron. However, with the exception of three short conserved blocks of homology, the 5' flanking regions of the rat and human genes are unrelated. Hence, these genes each encoding an identical protein are transcribed under the influence of divergent promoters. Blot analyses using RNA from a variety of transformed cells derived from different tissues indicate that expression of the human alpha-tubulin gene is restricted to cells of neurological origin. Among neurological cell types b alpha 1 expression is further restricted to adherent cells that are morphologically differentiated. The data presented suggest that the b alpha 1 gene encodes a prominent neuronal and glial alpha-tubulin and that b alpha 1 expression is a function of the differentiated state of these cells.
INTEGRATED IP COMMUNICATION SOLUTIONS FOR PUBLIC SAFETY WORKSHOP ON THE RESULTS OF THE EU-PROJECTS U-2010 & HNPS (2010)

In a crisis communication and access to data and information, is critical for public safety services. Several EU projects tackle this topic. In this workshop, results from the u-2010 7 and HNPS 8 projects will be presented and discussed. The u-2010 project’s objective was to provide the most capable means of communication to everybody required to act in case of accident, catastrophe or crisis, as well as the most
Synthesis of interleukin-1, interleukin-6, and basic fibroblast growth factor by human cataract lens epithelial cells (1996)

After cataract surgery, IL-1, IL-6, and b-FGF may be produced in vivo by residual LECs, causing postoperative inflammation and LEC proliferation.
Preparation and reactions of alkyl- and arylpentacarbonyltungsten anions (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of alkyl- and arylpentacarbonyltungsten anionsCharles P. Casey and Stanley W. PolichnowskiCite this: J. Am. Chem. Soc. 1978, 100, 24, 7565–7568Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/ja00492a022https://doi.org/10.1021/ja00492a022research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A New Angular-Velocity-Modulation System Employing Pulse Techniques (1946)

A method is described wherein crystal-controlled phase- or frequency-modulated carriers may be produced having relatively large deviation angles. A circuit is described wherein the harmonic distortion during modulation is held to a low value. An experimental transmitter is shown utilizing one form of the system. Also shown are oscillograms of the voltages occurring in various portions of the modulation system.
An Iterative Learning Controller for Nonholonomic Mobile Robots (1998)

We present an iterative learning controller that applies to nonholo nomic mobile robots, as well as other systems that can be put in chained form. The learning algorithm exploits the fact that chained- form systems are linear under piecewise-constant inputs. The pro posed control scheme requires the execution of a small number of experiments to drive the system to the desired state in finite time, with nice convergence and robustness properties with respect to model ing inaccuracies as well as disturbances. To avoid the necessity of exactly reinitializing the system at each iteration, the basic method is modified so as to obtain a cyclic controller, by which the system is cyclically steered through an arbitrary sequence of states. As a case study, a carlike mobile robot is considered. Both simulation and experimental results are reported to show the performance of the method.
Return Cycle Mapping After Entrainment of Ventricular Tachycardia (1998)

Return cycle mapping after entrainment localizes the central common pathway without pacing at the pathway or recording the potentials from the pathway. This new mapping technique could improve the success rate of the ablative procedures.
Phase I/II Study of a Candidate Vaccine Designed Against the B and E Subtypes of HIV-1 (2004)

A phase I/II trial of a candidate vaccine to prevent HIV infection was carried out in Bangkok, Thailand, testing AIDSVAX B/E (VaxGen, Inc., Brisbane, CA), a bivalent subunit vaccine prepared by combining recombinant gp120 from a subtype B virus (HIV-1MN) with gp120 from a subtype E virus (HIV-1A244) in alum adjuvant. The studies provide human data on the immunogenicity of various dose combination of non-subtype B vaccine antigens. The results suggest that AIDSVAX B/E is safe and immunogenic in humans. The optimal dose for humans in developing countries was 300 microg of each antigen (B and E). Clade E responses were measurably increased by immunizing with gp120 B/E over B alone. Using the B/E combination did not interfere with the response to either clade. Antibodies to AIDSVAX B/E were able to bind to oligomeric gp120 on the surface of cells infected with primary isolates of HIV-1.
Porous Silicon as a Nanostructured Template for Enhanced Immobilization and Crystallization of Inorganic and Biomaterials (2011)

In the current paper, we review our experimental and theoretical results demonstrating enhanced immobilization and crystallization of inorganic and biological materials on porous silicon and present additional explanation of observed effects. The examples of experimental results on room-temperature crystallization of SiO2 as well as of enhanced adhesion and crystallization of ceramic sol-gel derived films on porous silicon are shown. These phenomena have been observed at conditions which were insufficient for crystallization on flat silicon surfaces. The facilitation of crystallization on porous silicon is explained by surface fractality as well as by the decrease of potential barrier of nucleation related to the decrease of the critical nucleus volume at heterogeneous nucleation in pores.
Secured-by-Design FPGA against Early Evaluation (2017)

CMOS power dissipation has multiple components: switching, short-circuit, and static. In order to be robust to power attacks, digital logic should eliminate the relation between processed data and each and every power component. Other sources of side-channel information are glitches and the early evaluation of signals. We improve over our previous work and propose a Look-Up Table (LUT) with increased robustness to early evaluation attacks. The resulting secured-by-design FPGA LUT exhibits quadruple robustness to attacks based on dynamic power, static power, glitches, and early evaluation, whereas its architecture remains in line with commercial FPGAs. The silicon area penalty is light making the disclosed FPGA attractive to cryptoysystems developers.
Fully depleted CMOS/SOI device design guidelines for low-power applications (1999)

We report the fully depleted (FD) CMOS/SOI device design guidelines for low-power applications. Optimal technology, device and circuit parameters are derived and compared with bulk CMOS based design. The differences and similarities are summarized. Device design guidelines using devices with L=0.1 /spl mu/m for FDSOI low-power applications are presented using an empirical drain saturation current model fitted to experimental data. The model is verified in the deep-submicron regime by two-dimensional (2-D) simulation. For L=0.1 /spl mu/m FDSOI low-power technology, optimum speed and lower-power occurs at V/sub dd/=3V/sub th/ and V/sub dd/=1.5 V/sub th/, respectively. Optimum buried oxide thickness is found to be between 300 and 400 nm for low-power applications. Optimum transistor sizing is when the driver device capacitance is 0.3 times the total load capacitance. Similarly optimum gate oxide thickness is when the driver device gate capacitance is 0.2-0.6 times the total load capacitance for performance and 0.1-0.2 for low-power, respectively. Finally optimum stage ratio for driving large loads is around 2-4 for both high-performance and low-power.
Gas-sensing properties of metal-oxide nanostructures produced by PLD (2019)

We report the fabrication of gas sensor elements by pulsed laser deposition in air at atmospheric pressure. We focused our attention on metal-oxide semiconductors, namely, SnO<sub>2</sub>, TiO<sub>2</sub> and MoO<sub>3</sub> and studied the samples’ structure and morphology. The deposition technology applied leads to the formation of nanostructures composed of nanoparticles and nano-aggregates. We report preliminary results on the gas-sensing properties of the metal-oxide nanostructures. The sensors were exposed to CO, acetone and ethanol, with the TiO<sub>2</sub> nanostructure demonstrating the highest response to CO exposure.
Microscopie et spectroscopie de fluorescence en champ proche optique à sonde sans ouverture (2003)

International audience
Calculated Reactivity Indices and Bond Distances for Thieno[2,3-c]pyridazine (1976)

The ca!c&Zed heac
Seasonal Local Models for Glucose Prediction in Type 1 Diabetes (2019)

Linear empirical dynamic models have been widely used for blood glucose prediction and risks prevention in people with type 1 diabetes. More accurate blood glucose prediction models with longer prediction horizon (PH) are desirable to enable warnings to patients about imminent blood glucose changes with enough time to take corrective actions. In this study, a blood glucose prediction method is developed by integrating the predictions of a set of seasonal local models (each of them corresponding to different glucose profiles observed along historical data). In the modeling step, the number of sets and their corresponding glucose profiles characteristics are obtained by clustering techniques (Fuzzy C-Means). Then, Box-Jenkins methodology is used to identify a seasonal model for each set. Finally, blood glucose predictions of local models are integrated using different techniques. The proposed method is tested by using 18 60-h closed-loop experiments (including different exercise types and artificial pancreas strategies) and achieving mean absolute percentage error (MAPE) of 2.94%, 3.89%, 5.41%, 6.29% and 8.66% for 15-, 30-, 45-, 60-, and 90-min PHs, respectively.
Capsular tension ring–based in vitro capsule opacification model (2008)

The CTR-supported in vitro PCO model offers a physiological method to support the lens capsule and is a reproducible system for the study of LEC proliferation.
Assessment and optimization of electroporation-assisted tumoral nanoparticle uptake in a nude mouse model of pancreatic ductal adenocarcinoma (2014)

Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal form of cancer. In 2012, the incidence of PDAC was 43,920. Five-year survival for patients with PDAC is around 6%, regardless of staging, making PDAC one of the deadliest forms of cancer. One reason for this dismal prognosis is chemoresistance to the current first-line therapy, gemcitabine. There are multiple factors that contribute to the chemoresistance observed in pancreatic cancer. Among them, desmoplasia has been increasingly seen as a significant contributor to chemoresistance. To overcome desmoplastic chemoresistance, several novel methods of treatment have been developed. Electroporation is one such novel treatment. High electrical fields are applied to cells to create pores that increase cell permeability. It has been previously demonstrated that electroporation enhances the therapeutic efficacy of anticancer drugs in pancreatic tumor models. Nanoparticle-based drug delivery systems constitute a second novel method to overcome desmoplastic chemoresistance. Due to their intrinsic design advantages, nanoparticles have been shown to increase the effectiveness of chemotherapeutic agents, while further reducing or even eliminating side effects. To date, there have been no studies evaluating the cumulative effect of combining both nanoparticle and electroporation strategies to overcome chemoresistance in PDAC. Our preliminary studies assessed the in vitro and in vivo uptake of doxorubicin-loaded iron oxide nanoparticles as a function of electroporation voltage and timing of administration in pancreatic adenocarcinoma cells. Our studies demonstrated that addition of electroporation to administration of nanoparticles significantly increased the amount of intracellular iron oxide nanoparticle uptake by a PANC-1 cell line in an athymic nude mouse model of PDAC. Further, electroporation-assisted nanoparticle uptake could be significantly altered by changing the timing of application of electroporation.
Inhibition of the centrally induced increases in myocardial oxygen demand in rabbits by chronic treatment with baclofen, a selective GABAB agonist (1995)

1. A previous study from our group demonstrated that neurones of the paraventricular nucleus of the hypothalamus (PVN) are selectively involved in the central control of the cardiac function. Moreover, in that study, it was shown that baclofen, a selective GABAB receptor agonist, is capable of modulating the increases in myocardial contractility and oxygen demand evoked by electrical or pharmacological stimulation of the PVN. Nevertheless, the acute administration of this compound was frequently accompanied by a cardiodepressant effect. 2. In the present study, the effects of a long term treatment (14 days) with baclofen (3 or 10 mg kg-1, i.p.) have been examined on the excitatory haemodynamic responses evoked by central pharmacological stimulation in anaesthetized rabbits. 3. The i.c.v. injection of L-glutamate (3 mg kg-1) induced marked increases in dP/dtmax (32%), mean arterial pressure (39%) and on two indices of myocardial oxygen consumption: the rate-pressure product (34%) and the triple product (78%). 4. Baclofen blunted the positive inotropic response and the increases in myocardial oxygen consumption induced by L-glutamate in a dose-related manner. The higher dose of baclofen (10 mg kg-1, i.p.), reduced by more than 50% these excitatory effects of L-glutamate without eliciting any significant negative effect on basal haemodynamics. The same doses of baclofen were not able to blunt the hypertensive response induced by central stimulation. 5. These results confirm and extend our previous findings suggesting that it is possible to discriminate the central control of vasomotor tone from that of cardiac function and also that baclofen can modulate the latter. It is concluded that when given chronically, baclofen modulates the increases in myocardial oxygen demand induced by activation of the central nervous system in doses which do not depress the resting cardiac function.
Automated Horizon and Geobody Extraction Using 3D Seismic Waveform Sequences (2007)

B014 Automated Horizon and Geobody Extraction Using 3D Seismic Waveform Sequences H.G. Borgos* (Schlumberger) O. Gramstad (Schlumberger) G.V. Dahl (Schlumberger) P. Le Guern (Schlumberger) L. Sonneland (Schlumberger) &amp; J.F. Rosalba (Petrobras) SUMMARY A methodology for automated 3D interpretation is presented. Sequences of horizons (seismic events) are constructed from pre-computed horizon primitives. These horizon primitives are subsequently used to generate geobodies. Classification techniques can be applied to automatically group seismic events into classes of similar seismic waveform when performing seismic interpretation as described by Borgos et al. (2003). In this work we describe how the classification approach can be used to
Optical racetrack resonator transduction of nanomechanical cantilevers (2014)

Optomechanical transduction has demonstrated its supremacy in probing nanomechanical displacements. In order to apply nano-optomechanical systems (NOMS) as force and mass sensors, knowledge about the transduction responsivity (i.e. the change in measured optical transmission with nanomechanical displacement) and its tradeoffs with system design is paramount. We compare the measured responsivities of NOMS devices with varying length, optomechanical coupling strength gom, and optical cavity properties. Cantilever beams 1.5 to 5 μm long are fabricated 70 to 160 nm from a racetrack resonator optical cavity and their thermomechanical (TM) noise signals are measured. We derive a generic expression for the transduction responsivity of the NOMS in terms of optical and mechanical system parameters such as finesse, optomechanical coupling constant, and interaction length. The form of the expression holds direct insight as to how these parameters affect the responsivity. With this expression, we obtain the optomechanical coupling constants using only measurements of the TM noise power spectra and optical cavity transmission slopes. All optical pump/probe operation is also demonstrated in our side-coupled cantilever-racetrack NOMS. Finally, to assess potential operation in a gas sensing environment, the TM noise signal of a device is measured at atmospheric pressure.
Mechanism of Drug Resistance of Hemagglutinin of Influenza Virus and Potent Scaffolds Inhibiting Its Function (2012)

Highly pathogenic influenza viruses have become a global threat to humans. It is important to select an effective therapeutic option suitable for the subtypes in an epidemic or pandemic. To increase the options, the development of novel antiviral agents acting on targets different from those of the currently approved drugs is required. In this study, we performed molecular dynamics simulations on a spike protein on the viral envelop, hemagglutinin, for the wild-type and three kinds of mutants using a model system consisting of a trimeric hemagglutinin complex, viral lipid membrane, solvation waters, and ions. A natural product, stachyflin, which shows a high level of antiviral activity specific to some subtypes of influenza viruses, was examined on binding to the wild-type hemagglutinin by docking simulation. The compound potency of stachyflin is, however, easily lost due to resistant mutations. From a comparison of simulation results between the wild-type and the resistant mutants, the reason for the drug resistance of hemagglutinin was clarified. Next, 8 compounds were selected from a chemical database by in silico screening, considering the findings from the simulations. Inhibitory activities to suppress the proliferation of influenza virus were measured by cell-based antiviral assays, and two chemical scaffolds were found to be potent for an inhibitor. More than 30 derivatives bearing either of these two chemical scaffolds were synthesized, and cell culture assays were carried out to evaluate the compound potency. Several derivatives displayed a high compound potency, and 50% effective concentrations of two synthesized compounds were below 1 μM.
Crawling Along the Pareto Front: Tales From the Practice (2005)

We present a case study of applying multi-objective optimization techniques to the three dimensional design of a turbine blade in a gas turbine that is designed for use in a small business jet. We illustrate the iterative approach to the formulation of the fitness function that is characteristic for such a practical problem and show how the Pareto front accumulated in this process may serve to represent the knowledge on this problem that was collected in the complete optimization process
MIST: L0 Sparse Linear Regression with Momentum (2014)

Significant attention has been given to minimizing a penalized least squares criterion for estimating sparse solutions to large linear systems of equations. The penalty is responsible for inducing sparsity and the natural choice is the so-called $l_0$ norm. In this paper we develop a Momentumized Iterative Shrinkage Thresholding (MIST) algorithm for minimizing the resulting non-convex criterion and prove its convergence to a local minimizer. Simulations on large data sets show superior performance of the proposed method to other methods.
Speed-accuracy tradeoffs in human speech production (2018)

Speech motor actions are performed quickly, while simultaneously maintaining a high degree of accuracy. Are speed and accuracy in conflict during speech production? Speed-accuracy tradeoffs have been shown in many domains of human motor action, but have not been directly examined in the domain of speech production. The present work seeks evidence for Fitts' law, a rigorous formulation of this fundamental tradeoff, in speech articulation kinematics by analyzing USC-TIMIT, a real-time magnetic resonance imaging data set of speech production. A theoretical framework for considering Fitts' law with respect to models of speech motor control is elucidated. Methodological challenges in seeking relationships consistent with Fitts' law are addressed, including the operational definitions and measurement of key variables in real-time MRI data. Results suggest the presence of speed-accuracy tradeoffs for certain types of speech production actions, with wide variability across syllable position, and substantial variability also across subjects. Coda consonant targets immediately following the syllabic nucleus show the strongest evidence of this tradeoff, with correlations as high as 0.72 between speed and accuracy. A discussion is provided concerning the potentially limited applicability of Fitts' law in the context of speech production, as well as the theoretical context for interpreting the results.
Pulmonary embolism originating from germ cell tumor causes severe left ventricular dysfunction in a healthy young adult with full recovery: a case report (2021)

This case raises our awareness of unusual clinical presentation as we report associated left-sided severe heart failure in cancer-related pulmonary embolism. Pulmonary embolism in healthy young adults warrant in-depth causative exploration.
Total Variance as an Exact Analysis of the Sample Variance (1997)

Given a sequence of fractional frequency deviates, we investigate the relationship between the sample variance of these deviates and the total variance (Totvar) estimator of the Allan variance. We demonstrate that we can recover exactly twice the sample variance by renormalizing the Totvar estimator and then summing it over dyadic averaging times 1, 2, 4,..., 2 J along with one additional term that represents variations at all dyadic averaging times greater than 2 J. This decomposition of the sample variance mimics a similar theoretical decomposition in which summing the true Allan variance over all possible dyadic averaging times yields twice the process variance. We also establish a relationship between the Totvar estimator of the Allan variance and a biased maximal overlap estimator that uses a circularized version of the original fractional frequency deviates. 1
Atrial fibrillation ablation using very short duration 50 W ablations and contact force sensing catheters (2018)

Short duration 50 W ablations using CF sensing catheters are safe and result in excellent long-term freedom from AF for both paroxysmal and persistent AF with short procedure times and small amounts of total RF energy delivery.