gebhart/patrepeval huggingface dataset:
Improving Visual Place Recognition Performance by Maximising\n Complementarity (2021)

Visual place recognition (VPR) is the problem of recognising a previously\nvisited location using visual information. Many attempts to improve the\nperformance of VPR methods have been made in the literature. One approach that\nhas received attention recently is the multi-process fusion where different VPR\nmethods run in parallel and their outputs are combined in an effort to achieve\nbetter performance. The multi-process fusion, however, does not have a\nwell-defined criterion for selecting and combining different VPR methods from a\nwide range of available options. To the best of our knowledge, this paper\ninvestigates the complementarity of state-of-the-art VPR methods systematically\nfor the first time and identifies those combinations which can result in better\nperformance. The paper presents a well-defined framework which acts as a sanity\ncheck to find the complementarity between two techniques by utilising a\nMcNemar's test-like approach. The framework allows estimation of upper and\nlower complementarity bounds for the VPR techniques to be combined, along with\nan estimate of maximum VPR performance that may be achieved. Based on this\nframework, results are presented for eight state-of-the-art VPR methods on ten\nwidely-used VPR datasets showing the potential of different combinations of\ntechniques for achieving better performance.\n
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling (2020)

Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T cell persistence, especially for CAR T cells that target CD19<sup>+</sup> hematologic malignancies. 4-1BB-costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CAR (28ζ) T cells. 4-1BB signaling improves T cell persistence even in the context of 28ζ CAR activation, which indicates distinct prosurvival signals mediated by the 4-1BB cytoplasmic domain. To specifically study signal transduction by CARs, we developed a cell-free, ligand-based activation and ex vivo culture system for CD19-specific CAR T cells. We observed greater ex vivo survival and subsequent expansion of BBζ CAR T cells when compared to 28ζ CAR T cells. We showed that only BBζ CARs activated noncanonical nuclear factor κB (ncNF-κB) signaling in T cells basally and that the anti-CD19 BBζ CAR further enhanced ncNF-κB signaling after ligand engagement. Reducing ncNF-κB signaling reduced the expansion and survival of anti-CD19 BBζ T cells and was associated with a substantial increase in the abundance of the most pro-apoptotic isoforms of Bim. Although our findings do not exclude the importance of other signaling differences between BBζ and 28ζ CARs, they demonstrate the necessary and nonredundant role of ncNF-κB signaling in promoting the survival of BBζ CAR T cells, which likely underlies the engraftment persistence observed with this CAR design.
Lemierre's syndrome - the uncommon cold : : case report (2005)

Lemierre's syndrome (postanginal 
sepsis / necrobacillosis) is a rare clinical 
entity characterised by the triad of 
acute oropharyngeal infection, with 
secondary thrombophlebitis of the 
internal jugular vein and metastatic 
septic emboli. A high degree of clinical 
suspicion is needed to diagnose the 
syndrome and the radiologist's awareness 
of it may expedite the diagnosis 
and therefore the appropriate treatment 
for these potentially fatal sequelae 
of a 'sore throat'. 
lBRg We present a case of a 20-year-old 
man admitted to Helen Joseph 
Hospital in July 2004 with multiple 
lung abscesses, in whom internal 
jugular vein thrombophlebitis was 
subsequently diagnosed. Chest radiographic 
and computed tomography 
(CT) images accompany a brief 
review of this largely forgotten syndrome
A robust model for intelligent text classification (2002)

Methods for taking into account linguistic content into text retrieval are receiving growing attention. Text categorization is an interesting area for evaluating and quantifying the impact of linguistic information. Work on text retrieval through the Internet suggests that embedding linguistic information at a suitable level within traditional quantitative approaches is the crucial issue able to bring the experimental stage to operational results. This kind of representational problem is studied in this paper where traditional methods for statistical text categorization are augmented via a systematic use of linguistic information. The addition of NLP capabilities also suggested a different application of existing methods in revised forms. This paper presents an extension of the Rocchio formula as a feature weighting and selection model used as a basis for multilingual information extraction. It allows an effective exploitation of the available linguistic information that better emphasizes the latter with significant data compression and accuracy. The results is an original statistical classifier fed with linguistic features and characterized by the novel feature selection and weighting model. It outperforms existing systems while keeping most of their interesting properties. Extensive tests of the model suggest its application as a viable and robust tool for large scale text classification and filtering, as well as a basic module for more complex scenarios.
GPI7 Involved in Glycosylphosphatidylinositol Biosynthesis Is Essential for Yeast Cell Separation (2004)

GPI7 is involved in adding ethanolaminephosphate to the second mannose in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. We isolated gpi7 mutants, which have defects in cell separation and a daughter cell-specific growth defect at the non-permissive temperature. WSC1, RHO2, ROM2, GFA1, and CDC5 genes were isolated as multicopy suppressors of gpi7-2 mutant. Multicopy suppressors could suppress the growth defect of gpi7 mutants but not the cell separation defect. Loss of function mutations of genes involved in the Cbk1p-Ace2p pathway, which activates the expression of daughter-specific genes for cell separation after cytokinesis, bypassed the temperature-sensitive growth defect of gpi7 mutants. Furthermore, deletion of EGT2, one of the genes controlled by Ace2p and encoding a GPI-anchored protein required for cell separation, ameliorated the temperature sensitivity of the gpi7 mutant. In this mutant, Egt2p was displaced from the septal region to the cell cortex, indicating that GPI7 plays an important role in cell separation via the GPI-based modification of daughter-specific proteins in S. cerevisiae.
Storage and analysis of light-matter entanglement in a fiber-integrated system (2022)

The deployment of a full-fledged quantum internet poses the challenge of finding adequate building blocks for entanglement distribution between remote quantum nodes. A practical system would combine propagation in optical fibers with quantum memories for light, leveraging on the existing communication network while featuring the scalability required to extend to network sizes. Here, we demonstrate a fiber-integrated quantum memory entangled with a photon at telecommunication wavelength. The storage device is based on a fiber-pigtailed laser-written waveguide in a rare earth-doped solid and allows an all-fiber stable addressing of the memory. The analysis of the entanglement is performed using fiber-based interferometers. Our results feature orders-of-magnitude advances in terms of storage time and efficiency for integrated storage of light-matter entanglement and constitute a substantial step forward toward quantum networks using integrated devices.
Microbial colonization of nebulizers used by asthmatic children (2006)

Home nebulizers are frequently colonized with microorganisms. As recommended, nebulizers should be washed after each use and air-blown dry. Nebulizer maintenance should be emphasized in educational programs for managing asthma.
An on-chip delay- and skew-insensitive multicycle communication scheme (2006)

A synchronous latency-insensitive design (SLID) method that mitigates unknown on-chip global wire delays and removes the need for controlling global clock skew is presented. An SLID-based 5.4mm-long on-chip global bus, fabricated in a standard 0.18μm CMOS process, supports 3Gb/s/wire and accepts ±2 clock cycles of data-clock skew. This paper focuses on data synchronization for large global on-chip signals, which has become a difficult issue in high-frequency processor designs
Development of 193-nm wet BARCs for implant applications (2006)

This paper describes the chemistry and performance of a new family of wet-developable (wet) bottom anti-reflective coatings (BARCs) that have been developed for 193-nm implant layer applications. These BARCs, which are light sensitive and positive working, are imaged and developed in the same steps as the covering 193-nm photoresist. The BARCs are spin coated from organic solvents and then insolubilized during a hot plate bake step. The resulting cured films exhibit minimal solubility in numerous organic solvents. Resolution of a photoresist A and light-sensitive BARC I at optimum exposure (Eop) on a silicon substrate was 150-nm L/S (1:1), with good sidewall angle and no scumming. These best-case results utilize a first reflectivity minimum BARC thickness and meet the desired resolution goals for noncritical implant layers. BARC optical parameters can easily be adjusted by altering the polymeric binder. PROLITH<sup>TM</sup> modeling shows that near zero reflectance can be achieved on a silicon substrate for both a first and a second reflectivity minimum BARC thickness. The light-sensitive, wet BARCs are both spin-bowl and solution compatible with most industry standard solvents. A selected BARC from this family of wet products was shown to be stable, providing reproducible film properties over several months of ambient storage conditions.
Nanoliposomes@Transcutol for In Vitro Skin Delivery of 8-Methoxypsoralen (2021)

8-methoxypsoralen is the most common drug in psoralen plus ultraviolet light irradiation therapy for the treatment of severe psoriasis. Despite of the efficacy, its classic oral administration leads to several serious adverse effects. However, the topical psoralen application produces a drug skin accumulation lower than that obtained by oral administration, due to the drug low skin permeability. In this paper, 8-methoxypsoralen loaded Penetration Enhancer-containing Vesicles were prepared using soy phosphatidylcholine and the penetration enhancer Transcutol® (5% or 10%) and characterized in terms of size, polydispersity index, zeta potential and encapsulation efficiency. No statistically significant differences in both size (~135 nm) and encapsulation efficiency (~65%) were found for different Transcutol® concentration. Transdermal delivery study assessed by Franz diffusion cells, showed that the 8-methoxypsoralen mainly accumulated into the stratum corneum. Moreover, after Penetration Enhancer-containing Vesicles application, the drug recovered in this layer is almost double of that delivered by conventional liposomes, while no significant difference was found from the different Transcutol® concentrations. Finally, biocompatibility checked by an MTT assay, demonstrated that the incubation of human keratinocytes for 24 h with 8-methoxypsoralen loaded Penetration Enhancer-containing Vesicles did not significantly reduce cell viability.
The central role of corticotrophin‐releasing factor (CRF‐41) in psychological stress in rats. (1993)

1. We investigated the central role of corticotrophin-releasing factor (CRF-41) in psychological stress-induced responses, including cardiovascular, thermoregulatory and locomotive activity in free-moving rats. 2. Psychological stress was induced by cage-switch stress. After rats were placed in the novel environment, blood pressure, heart rate, body temperature and locomotive activity significantly increased. The intracerebroventricular (I.C.V.) injection of alpha-helical CRF(9-41), a CRF-41 receptor antagonist, significantly attenuated the stress-induced hypertension, tachycardia, hyperthermia and increase in locomotive activity. However, in unstressed rats, the I.C.V. injection of alpha-helical CRF(9-41) had no effect on physiological parameters measured in this study. 3. In unstressed rats, the I.C.V. injection of CRF-41 (1 microgram and 10 micrograms) increased blood pressure, heart rate, body temperature and locomotive activity in a dose-dependent manner. The changes in these responses were quite similar to those observed during cage-switch stress. 4. The results suggest that central CRF-41 plays an important role in psychological stress-induced hypertension, hyperthermia, tachycardia and increase in locomotive activity. However, it is likely that central CRF-41 does not contribute to normal cardiovascular and body temperature regulation when rats are free from stress.
Intermolecular Optical Electron Transfers in Polyether Hybrid Molten Salts of Mixed-Valent Ruthenium Complexes (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTIntermolecular Optical Electron Transfers in Polyether Hybrid Molten Salts of Mixed-Valent Ruthenium ComplexesJason E. Ritchie and Royce W. MurrayView Author Information Kenan Laboratories of Chemistry University of North Carolina Chapel Hill, North Carolina 27599 Cite this: J. Am. Chem. Soc. 2000, 122, 12, 2964–2965Publication Date (Web):March 10, 2000Publication History Received2 December 1999Published online10 March 2000Published inissue 1 March 2000https://pubs.acs.org/doi/10.1021/ja994221khttps://doi.org/10.1021/ja994221krapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views204Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transfer,Counterions,Energy,Ions,Redox reactions Get e-Alerts
Dissection and Culture of Mouse Dopaminergic and Striatal Explants in Three-Dimensional Collagen Matrix Assays (2012)

Midbrain dopamine (mdDA) neurons project via the medial forebrain bundle towards several areas in the telencephalon, including the striatum(1). Reciprocally, medium spiny neurons in the striatum that give rise to the striatonigral (direct) pathway innervate the substantia nigra(2). The development of these axon tracts is dependent upon the combinatorial actions of a plethora of axon growth and guidance cues including molecules that are released by neurites or by (intermediate) target regions(3,4). These soluble factors can be studied in vitro by culturing mdDA and/or striatal explants in a collagen matrix which provides a three-dimensional substrate for the axons mimicking the extracellular environment. In addition, the collagen matrix allows for the formation of relatively stable gradients of proteins released by other explants or cells placed in the vicinity (e.g. see references 5 and 6). Here we describe methods for the purification of rat tail collagen, microdissection of dopaminergic and striatal explants, their culture in collagen gels and subsequent immunohistochemical and quantitative analysis. First, the brains of E14.5 mouse embryos are isolated and dopaminergic and striatal explants are microdissected. These explants are then (co)cultured in collagen gels on coverslips for 48 to 72 hours in vitro. Subsequently, axonal projections are visualized using neuronal markers (e.g. tyrosine hydroxylase, DARPP32, or βIII tubulin) and axon growth and attractive or repulsive axon responses are quantified. This neuronal preparation is a useful tool for in vitro studies of the cellular and molecular mechanisms of mesostriatal and striatonigral axon growth and guidance during development. Using this assay, it is also possible to assess other (intermediate) targets for dopaminergic and striatal axons or to test specific molecular cues.
Electrochemically Deposited Diffusion Barriers (1994)

Diffusion barrier properties of electrochemically deposited Ni, Co, and Ni‐Co alloys were examined in the binary system and the Au/Ni/Cu ternary system. Ni and Co were electrodeposited from sulfate or sulfamate (Ni) solutions in the presence of boric acid, at pH 3.30. Electroless Ni and Co deposited either from sulfate or sulfamate solution using sodium hypophosphite or dimethylamine borane as the reducing agent. Electroless gold was deposited from cyanide solutions using potassium borohydride as the reducing agent. The deposits were annealed at 400°C for 14 h in a forming gas atmosphere (10% , 90% ). Auger electron spectroscopy and electron probe analysis were used to assess the extent of interdiffusion as a result of the heat‐treatment. Only electrolessly deposited 1000 Å thick Ni, Co, and Ni‐Co alloys have barrier properties for Cu diffusion. For 1000 Å thick barriers, annealed for 14 h, the amount of the interdiffused copper into was less than 1 atomic percent. Thicker barriers of , , and are required for the same degree of Cu diffusion. thin films deposited from nickel sulfamate solutions are better diffusion barriers than those deposited under the same experimental conditions, from nickel sulfate solutions. Electrochemically deposited barriers were compared with Ni, Co, and Cr barriers produced by evaporation. The differences between the diffusion barrier properties of deposited from the sulfamate and the sulfate solutions were interpreted in term of microstructural data and grain growth mechanism.
A Method to Define the Efficiency of Damping Devices for Single and Bundled Conductors of EHV and UHV Lines (1987)

This paper deals with an experimental method to define an adimensional parameter able to characterize the damping introduced by suitable damping devices for EHV and UHV lines subjected to aeolian vibrations. This adimensional parameter is defined through tests on a laboratory span and allows not only to obtain a comparison between the efficiencies of different damping devices (dampers and spacer-dampers), but also to evaluate whether such damping devices, placed on a real span, are sufficient to keep the strains below the limit values. The proposed method is useful both in the case of a single conductor and in that of a bundle.
Progress overview of EUV resists status towards high-NA EUV lithography (2019)

We investigated how the processing parameters, including post exposure baking (PEB), and resist film thickness (FT) influence the dose and line width roughness (LWR) of different types of EUV resists, targeted for the high-NA EUV lithography. We compared the dose and LWR of molecular, inorganic and CAR resists at half-pitch (HP) of 16 and 14 nm for different PEB temperatures. The results show that without PEB or at lower PEB temperature, resists require higher doses, as expected. We also observed the different behavior of various resist platforms in response to variation of the film thickness. The results showed that there is a room for the optimization of the processing parameters to improve dose and LWR of molecular, inorganic and CAR resists for line/space printing at high resolution.
Minor Immunoreactivity in GDNF‐, BDNF‐, or NT‐3‐Treated Substantia Nigra Allografts (1997)

Glial-cell-line-derived neurotrophic factor (GDNF) stimulates the survival of dopaminergic neurons. Little is known, however, about the possible immune sequelae of GDNF exposure or of exposure to other putative trophic factors. To address these questions, pieces of mesencephalic tissue, substantia nigra, from 15-day-old donor embryos were transplanted into the anterior chamber of the eye of adult male Sprague-Dawley recipient rats. At 5-day intervals, an aliquot (0.5 microgram) of GDNF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or cytochrome-C (CC) was injected into the anterior chamber of the eye of the recipients, and the sizes of the transplants were measured. GDNF increased transplant survival and growth. On day 42, all rats were sacrificed, and the grafts were evaluated by cresyl-violet staining and by immunohistochemistry using antibodies raised against neurofilament (NF), tyrosine hydroxylase, or glial fibrillary acidic protein (GFAP), as well as the following monoclonal antibodies: OX-38 anti-CD4, OX-8 anti-CD8, OX-18 anti-MHC class I, OX-6 anti-MHC class II, OX-42 anti-CD11b, R-73 anti-alpha and anti-beta T-cell receptor, and ED1 raised against monocytes/macrophages. BDNF-treated grafts showed only weak immunoreactivity, and even weaker reactions were seen in grafts treated with NT-3, GDNF, or CC. No single immune system marker was significantly elevated in grafts from any treatment group. We used OX-42 and ED1 to study possible alterations of microglial components. Ramified microglial cells were found in GDNF-treated grafts and to a lesser extent in NT-3 and BDNF-treated grafts. ED1-labeled reactive microglial components were found in NT-3- and BDNF-treated grafts. Additionally, large and rounded OX-42-positive phagocytic cells were found in NT-3-treated grafts. Together with our previous finding that GDNF treatment of spinal cord transplants activates immune responses and leads to microglial activation, our data demonstrate that although treatment with GDNF and to some degree with BDNF can enhance immune responses to immunogenic grafts, such as fetal spinal cord grafts, but the trophic factors per se do not elicit any marked response in non-immunogenic grafts like substantia nigra.
A heat dissipation tutorial for wearable computers (2002)

Wearable computing brings computation much closer to the user for everyday tasks and may be worn during most of the day. However, with CPU and wireless network intensive applications, higher power microprocessors and radio links are necessary resulting in increased heat generation. This paper suggests a method to increase the hear dissipation capability per unit surface area of a mobile computer by coupling it to the user. In addition, this paper presents tools and guidelines for determining the placement of heat dissipating components.