gebhart/patrepeval huggingface dataset:
SCANimate: Weakly Supervised Learning of Skinned Clothed Avatar Networks (2021)

We present SCANimate, an end-to-end trainable framework that takes raw 3D scans of a clothed human and turns them into an animatable avatar. These avatars are driven by pose parameters and have realistic clothing that moves and deforms naturally. SCANimate does not rely on a customized mesh template or surface mesh registration. We observe that fitting a parametric 3D body model, like SMPL, to a clothed human scan is tractable while surface registration of the body topology to the scan is often not, because clothing can deviate significantly from the body shape. We also observe that articulated transformations are invertible, resulting in geometric cycle-consistency in the posed and unposed shapes. These observations lead us to a weakly supervised learning method that aligns scans into a canonical pose by disentangling articulated deformations without template-based surface registration. Furthermore, to complete missing regions in the aligned scans while modeling pose-dependent deformations, we introduce a locally pose-aware implicit function that learns to complete and model geometry with learned pose correctives. In contrast to commonly used global pose embeddings, our local pose conditioning significantly reduces long-range spurious correlations and improves generalization to unseen poses, especially when training data is limited. Our method can be applied to pose-aware appearance modeling to generate a fully textured avatar. We demonstrate our approach on various clothing types with different amounts of training data, outperforming existing solutions and other variants in terms of fidelity and generality in every setting. The code is available at https://scanimate.is.tue.mpg.de.
Dendrimer modified silica gel for anion exchange chromatography: synthesis, characterization and application (2012)

The novel grafted silica supports were investigated. The anion exchanger was prepared by chemical modification of a bare silica gel surface. The support was coated with a polymeric moiety formed by condensation polymerization of primary amine with diepoxide. The synthesized copolymer of methylamine (MA) and 1,4-butanedioldiglycidyl ether (BDDE) exhibited a dendrimer structure. The prepared materials were characterized by elemental analysis, FT-IR spectroscopy and solid state (13)C and (29)Si NMR CP-MAS spectroscopy. The porous structure of the adsorbents was investigated using the low temperature nitrogen adsorption (LTNA) method. It allows determination of the influence of the topology of packing materials on their chromatographic properties. Imaging was also carried out on the surfaces of the synthesized materials by scanning electron microscopy (SEM). The obtained stationary phase was applied in ion chromatography for the separation of inorganic anions (F(-), Cl(-), NO(2)(-), Br(-), NO(3)(-), HPO(4)(2-), SO(4)(2-), ClO(4)(-)). Bicarbonate buffer was used as a mobile phase.
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023)

The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended.
Foretinib mitigates cutaneous nerve fiber loss in experimental diabetic neuropathy (2022)

Diabetes is by far, the most common cause of neuropathy, inducing neurodegeneration of terminal sensory nerve fibers associated with loss of sensation, paresthesia, and persistent pain. Foretinib prevents die-back degeneration in cultured sensory and sympathetic neurons by rescuing mitochondrial activity and has been proven safe in prospective clinical trials. Here we aimed at investigating a potential neuroprotective effect of Foretinib in experimental diabetic neuropathy. A mouse model of streptozotocin induced diabetes was used that expresses yellow fluorescent protein (YFP) in peripheral nerve fibers under the thy-1 promoter. Streptozotocin-injected mice developed a stable diabetic state (blood glucose > 270 mg/dl), with a significant reduction of intraepidermal nerve fiber density by 25% at 5 weeks compared to the non-diabetic controls. When diabetic mice were treated with Foretinib, a significantly greater volume of the cutaneous nerve fibers (67.3%) in the plantar skin was preserved compared to vehicle treated (37.8%) and non-treated (44.9%) diabetic mice while proximal nerve fiber morphology was not affected. Our results indicate a neuroprotective effect of Foretinib on cutaneous nerve fibers in experimental diabetic neuropathy. As Foretinib treated mice showed greater weight loss compared to vehicle treated controls, future studies may define more sustainable treatment regimen and thereby may allow patients to take advantage of this neuroprotective drug in chronic neurodegenerative diseases like diabetic neuropathy.
Construction of Highly Oriented Crystalline Surface Coordination Polymers Composed of Copper Dithiooxamide Complexes (2008)

Layer-by-layer bottom-up crystal engineering of metal-organic crystals at the surface of sapphire or glass from organic (rubeanic acid and derivatives) and inorganic (Cu(2+)) components which when mixed in solution form instantly an amorphous solid with high proton conduction.
Expression and Purification of Recombinant Hemoglobin in Escherichia coli (2011)

Our protocol should prove useful for the experimental study of recombinant Hbs in many non-human animals. One of the chief advantages of our protocol is that we can express soluble recombinant Hb without co-expressing molecular chaperones, and without the need for additional reconstitution or heme-incorporation steps. Moreover, our plasmid construct contains a combination of unique restriction sites that allows us to produce recombinant Hbs with different α- and β-chain subunit combinations by means of cassette mutagenesis.
Environmentally Opportunistic Computing transforming the data center for economic and environmental sustainability (2010)

The United States Environmental Protection Agency forecasts the 2011 national IT electric energy expenditure will grow toward $7.4 billion [1]. In parallel to economic IT energy concerns, the general public and environmental advocacy groups are demanding proactive steps toward sustainable green processes. Our contribution to the solution of this problem is Environmentally Opportunistic Computing (EOC). Our Green Cloud EOC prototype serves as an operational demonstration that IT resources can be integrated with the dominate energy footprint of existing facilities and dynamically controlled to balance process throughput, thermal transfer, and available cooling via process management and migration. The Green Cloud is a sustainable computing technology that complements existing efficiency improvements at the application, operating system and hardware levels. Exhaust heat energy is transferred directly to an adjacent greenhouse facility and cooling is provided by free cooling methods. We will describe the architecture and operation of this successful prototype that has led to its growing use in our production environments.
Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis (2023)

Abstract Changes in chondrocyte gene expression can contribute to the development of osteoarthritis (OA), and so recognition of the regulative processes during chondrogenesis can lead to a better understanding of OA. microRNAs (miRNAs) are key regulators of gene expression in chondrocytes/OA and we have used a combined experimental, bioinformatic, and systems biology approach to explore the multiple miRNA-mRNA interactions that regulate chondrogenesis. A longitudinal chondrogenesis bioinformatic analysis identified paralogues miR-199a-5p and miR-199b-5p as pro-chondrogenic regulators. Experimental work demonstrated alteration of miR-199a-5p or miR-199b-5p expression led to significant inverse modulation of key chondrogenic genes and extracellular matrix production. miR-199a/b-5p targets FZD6, ITGA3 and CAV1 were identified by inhibition experiments and verified as direct targets by luciferase assay. The experimental work was used to generate and parameterize a multi-miRNA 14-day chondrogenesis kinetic model to be used as a repository for the experimental work and as a resource for further investigation of this system. This is the first multi-miRNA model of a chondrogenesis-based system, and highlights the complex relationships between regulatory miRNAs, and their target mRNAs.
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions (2016)

In this review, we describe the recent advances in supramolecular helical assemblies formed from chiral and achiral small molecules, oligomers (foldamers), and helical and nonhelical polymers from the viewpoints of their formations with unique chiral phenomena, such as amplification of chirality during the dynamic helically assembled processes, properties, and specific functionalities, some of which have not been observed in or achieved by biological systems. In addition, a brief historical overview of the helical assemblies of small molecules and remarkable progress in the synthesis of single-stranded and multistranded helical foldamers and polymers, their properties, structures, and functions, mainly since 2009, will also be described.
Eco-engineered coastal defense integrated with sustainable aquatic food production in Bangladesh (ECOBAS) (2015)

The objective of the ECOBAS project is to provide the coastal people of Bangladesh with an alternative approach for adaptation to coastal erosion and flooding. By using the concept of “eco-engineering” the natural resistance of shellfish reefs against hydrodynamic forces reduces human vulnerability to coastal erosion and flooding, and delivers a source of aquatic food. ECOBAS stands for ECO-engineered Coastal Defence Integrated with Sustainable Aquatic Food Production in BAngladeSh, and was executed by a multidisciplinary team of Dutch and Bangladesh research institutes. This report summarizes the outcomes of this study. It is not an in-depth report where scientific outcomes are discussed, but a summary for the funding agencies. The ECOBAS project was funded by Partners for Water. Also the Embassy of the Kingdom of the Netherlands financed extra monitoring activities in the second phase of the project which enabled generation of more data and a broader understanding of the research.
Efficacy and safety of losartan-amplodipine combination--an Indian postmarketing surveillance experience. (2002)

The present study was conducted among 719 patients enrolled by 109 doctors to evaluate the efficacy and tolerability of the combination of losartan potassium and amlodipine besylate in Indian patients with mild to moderate hypertension. Out of them 11 patients were dropped out. Of these 708 patients 643 patients received once daily dosage of the combination whereas 10 patients received 1/2 daily, 13 patients received 1 1/2 daily and 42 patients received 1 twice daily dosage of the combination. The mean SBP in the study was 172.89 +/- 19.18 mm Hg baseline. After the 10-day treatment, the mean SBP had significant reduction ie, 13.1% from basal and at the end of day 20 of the treatment, the reduction was 19.13% from the baseline which was significant. Similarly mean DBP was 105.42 +/- 10.85 mm Hg at baseline. After treatment, the mean DBP had significant reduction. After 10- day treatment, there was 12.7% reduction from the baseline and at the end of the treatment ie, after day 20, the reduction was 17.70% from basal, which was significant. Global evaluation of efficacy was done by the physicians; 93.8% of the cases had excellent to good response and 4.9% patients had fair response. Details of any adverse event reported or noted during the treatment with the combination were recorded in the appropriate section of the case record form, whether considered treatment related or not, as reported by the patients. The severity of an adverse event was graded on a 3-point scale as mild, moderate and severe. The most common side-effects reported were oedema of feet (5.08%), ankle oedema (1.98%). Remaining adverse events included some cardiovascular events such as palpitations, gastro-intestinal events such as constipation, miscellaneous events, muscular pain, weakness, generalised swelling, etc. CNS events included giddiness, headache, insomnia, etc.
Kinetic Study on Thermal Degradation of Polyimides. II. (1969)

1,2,3,4-ブタンテトラカルボン酸二無水物(BDA)とベンジジン(BZD)およびヘキサメチレンジアミン(HMDA)から脂肪族ポリイミドを合成し,それらの熱分解について動力学的解析を行ない比較検討した。これらの研究は一般に一連の定温下の測定で行なわれるが,本研究では昇温下で熱分解を測定した結果を動力学的に解析した。脂肪族ポリイミドの熱分解は四段階より成ることが確かめられた。主要な反応である脱炭酸と炭素鎖切断の分解は接近して起こり,脱炭酸は解析できなかった。炭素鎖切断の活性化エネルギーを,前報の結果も併せて,比較すると,ピロメリット酸二無水物(PDA)とBZDからのポリイミド,BDAとBZDからのポリイミド,PDAとHMDAからのポリイミド,BDAとHMDAからのポリイミドの順位となり,熱安定性から予想される結果と一致した。
Effects of gap on galvanic corrosion behavior of aluminum alloy A5052/carbon steel SS400 couples in NaCl solutions (2021)

Galvanic corrosion behavior of Al-Mg alloy A5052/carbon steel SS400 couples with different gaps was investigated in NaCl solutions at various concentrations. The corrosion morphology of the couples differed from each other depending on the gap and NaCl concentration. Steel corrosion was observed as NaCl concentration and/or the gap decreased. When the gap was 10 mm, no corrosion occurred on the SS400 side in all the test solutions, suggesting that anodic dissolution reaction was dominant on the AA5052 side. However, as the gap was decreased, the corrosion of the steel became obvious in the solutions at lower concentrations, although the A5052 also showed localized corrosion. These results indicated that anodic dissolution reaction was generated both on the A5052 and the SS400 under the smaller gap conditions with decreasing the NaCl concentrations. In this study, the effects of gap on the galvanic corrosion behavior were also discussed based on the results of the change in the solution chemistry in addition to galvanic current and potential of the A5052 and SS400 couples.
Omnidirectional object duplicate detection (2011)

In this paper, we extend a graph-based approach for omnidirectional object duplicate detection in still images. Objects are detected from several points of view with different distances. The goal of this work is to determine how many training images have to be taken and from which points of view in order to achieve a certain efficiency. Moreover, the performance of the algorithm is improved by automatically generated images, where the original training images are scaled and rotated in 3D space. Our experiments show that four training images are enough for 3D object duplicate detection from a planar view point and ten training images for omnidirectional detection.
Encyclopedia of Scientific Principles, Laws, and Theories, Second Edition (Robert E. Krebs) (2009)

The second edition of Robert E. Krebs’s Encyclopedia of Scientific Principles, Laws, and Theories is a two-volume, alphabetized desk reference encompassing a variety of key issues and principles from chemistry, biology, and physics.
Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease (2015)

Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.
A functionally active heavy chain derived from human high molecular weight urokinase. (1983)

Human high molecular weight urokinase, a plasminogen activator, when minimally reduced with 0.01 M 2-mercaptoethanol for 10 h at pH 8.0 and 25 degrees C and then carboxymethylated with sodium iodoacetate, gave two chains, a functionally active heavy chain with about 80% of the original activity and a light chain. These two chains were found to be linked by a single interchain disulfide bond. The functionally active heavy chain can be isolated by an affinity chromatography method with [N alpha-(epsilon-aminocaproyl)-DL-homoarginine hexylester]-Sepharose. The light chain, which has no enzyme activity, is not adsorbed to the affinity matrix, whereas the active heavy chain was adsorbed and subsequently eluted. The active heavy chain was further purified by gel filtration on Sephadex G-100. This preparation was found to be homogeneous by both analytical and sodium dodecyl sulfate-polyacrylamide disc gel electrophoresis. The molecular weight of the active heavy chain was determined to be 33,000 by Sephadex G-100 gel filtration and 31,000 by sodium dodecyl sulfate-polyacrylamide disc gel electrophoresis. Its specific activity, with L-pyroglutamyl-glycyl-L-arginine-p-nitroanilide, was determined to be 208,000 IU/mg of protein. Approximately 87% active sites were found by p-nitrophenyl-p'-guanidino-benzoate titration with a molar activity of 7.41 X 10(9) IU/mmol of active site. The active heavy chain when compared to low molecular weight urokinase has a similar molecular weight, specific activity, and amino acid composition. The NH2-terminal residue found in the active heavy chain was lysine which was the same as that found in low molecular weight urokinase, whereas the NH2-terminal residues found in high molecular weight urokinase were serine and lysine. Serine is the NH2-terminal residue of the light chain of high molecular weight urokinase. The steady state kinetic parameters of activation of human Glu-plasminogen by the active heavy chain were also similar to low molecular weight urokinase, as were the amidase parameters of these enzymes. The Michaelis constants of activation (Kplg) were 2.11 and 2.21 microM, respectively; the catalytic rate constants of activation (kplg) were 51.7 and 44.1 min-1, respectively, with second order rate constants, kplg/Kplg of 24.5 and 20.2 microM-1 min-1, respectively.
Direct Measurement of Magnetic Timing Jitter in Writers (2021)

Non-repeatable positioning of transitions in the media (jitter) is one of the primary limiting factors in achieving higher linear density in magnetic recording. In a typical magnetic recording system, the primary sources of jitter are due to the finite grain size and the switching field distribution of the grains in the media. These contributions to jitter are generally referred to as the "written-in" contributions [1] . However, if the system that delivers the write field to the media itself has jitter, as all real-world systems will, then this "timing jitter" will also contribute to the total written-in jitter.
Effects of Monatepil Maleate, a New Ca2+ Channel Antagonist With α1-Adrenoceptor Antagonistic Activity, on Cholesterol Absorption and Catabolism in High Cholesterol Diet-Fed Rabbits (1998)

The mechanism of the prophylactic effect against hyperlipidemia by monatepil maleate was investigated in animal models. Monatepil maleate is an antihypertensive agent with Ca2+-channel antagonistic, alpha1-adrenergic receptor-blocking, and lipid peroxidation inhibitory activity. In high cholesterol diet-fed rabbits, monatepil maleate (30 mg/kg, p.o., once daily for 9 weeks) showed a prophylactic effect against increases in total cholesterol and beta-lipoprotein. Monatepil maleate significantly accelerated the clearance of radioactivity from the blood after intravenous injection of low-density lipoprotein (LDL) labeled with [1alpha,2alpha (n)-3H]cholesterol, increasing biliary excretion of [3H]-bile acids without modifying bile acid composition. Furthermore, monatepil maleate tended to inhibit the absorption of orally administered [1alpha,2alpha (n)-3H]cholesterol from the gastrointestinal tract in these rabbits. In Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of hepatic LDL receptor deficiency, monatepil maleate (30 mg/kg, p.o., once daily for 6 months) did not suppress the increase in plasma lipids. These results suggest that the plasma lipid lowering effect of monatepil maleate requires the presence of hepatic LDL receptors. It is also suggested that monatepil maleate improves plasma lipid metabolism through two mechanisms: enhancement of clearance of plasma LDL, which may be mediated by up-regulation of hepatic LDL receptors, and acceleration of conversion of free cholesterol to bile acids in the liver.
Facies Modelling of a Real-Life Fluvial System Using a Modern Object-Based Algorithm (2018)

Summary When choosing which approach to take when doing facies modelling there has traditionally been a trade-off between geological realism and how much well data to incorporate into your model. If geological realism had the priority, the choices available typically are stochastic object-based modelling techniques. With an abundance of well data the choices have been pixel based algorithms, such as Indicator or Multi-Point Statistics, since object modelling has taken too long time to be able to correctly condition to the well data. Recently, we published a new object modelling algorithm that has significantly increased the well conditioning capability compared to previous methods. Here, we demonstrate this solution applied to a fluvial reservoir with meandering channels in the North Sea, where we obtain perfect well data conditioning for all four modelled facies, channel, levee, crevasse and background. The geological geometries that are needed to represent each of the facies are honoured, while still allowing for enough flexibility to condition to well data and maintaining their geological realistic shapes. With a significantly faster algorithm, the new facies object modelling solution again becomes relevant in any setting involving automatic generation of many realizations.
ChemInform Abstract: PROPELLANES. XXXI. THE DIELS‐ALDER REACTION OF (4.4.2)PROPELLANES WITH 4‐PHENYL‐1,2,4‐TRIAZOLINE‐3,5‐DIONE (1976)

Abstract Der Angriff des Dienophils (II) auf das Propellan (I) bzw. analog die Propellatriene (IV) und (V) erfolgt aus anti‐Richtung bzgl.
Active Contextual Entropy Search (2015)

Contextual policy search allows adapting robotic movement primitives to different situations. For instance, a locomotion primitive might be adapted to different terrain inclinations or desired walking speeds. Such an adaptation is often achievable by modifying a small number of hyperparameters. However, learning, when performed on real robotic systems, is typically restricted to a small number of trials. Bayesian optimization has recently been proposed as a sample-efficient means for contextual policy search that is well suited under these conditions. In this work, we extend entropy search, a variant of Bayesian optimization, such that it can be used for active contextual policy search where the agent selects those tasks during training in which it expects to learn the most. Empirical results in simulation suggest that this allows learning successful behavior with less trials.
Total Synthesis of (±)-Sermundone and An Alternative Cyclization Method to Dehydrorotenoids (1972)

(±)-Sermundone (2), one of the hydroxyrotenoids, has been synthesized. Also a new cyclization method to dehydrorotenoids has been developed using alkali metal salts.