gebhart/patrepeval huggingface dataset:
Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells (2014)

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity through effector-mediated functions. We have engineered the fragment crystallizable (Fc) region of the immunoglobulin G (IgG) mAb, HuM195, targeting the leukemic antigen CD33, by introducing the triple mutation Ser293Asp/Ala330Leu/Ile332Glu (DLE), and developed Time-lapse Imaging Microscopy in Nanowell Grids to analyze antibody-dependent cell-mediated cytotoxicity kinetics of thousands of individual natural killer (NK) cells and mAb-coated target cells. We demonstrate that the DLE-HuM195 antibody increases both the quality and the quantity of NK cell-mediated antibody-dependent cytotoxicity by endowing more NK cells to participate in cytotoxicity via accrued CD16-mediated signaling and by increasing serial killing of target cells. NK cells encountering targets coated with DLE-HuM195 induce rapid target cell apoptosis by promoting simultaneous conjugates to multiple target cells and induce apoptosis in twice the number of target cells within the same period as the wild-type mAb. Enhanced target killing was also associated with increased frequency of NK cells undergoing apoptosis, but this effect was donor-dependent. Antibody-based therapies targeting tumor antigens will benefit from a better understanding of cell-mediated tumor elimination, and our work opens further opportunities for the therapeutic targeting of CD33 in the treatment of acute myeloid leukemia.
Chapter 13 Polymer\textendashClay Nanocomposite Particles and Soap-free Latexes Stabilized by Clay Platelets: State of the Art and Recent Advances (2010)

International audience
Низкоэнергетическое состояние электронного пучка в коаксиальном диоде с однородным анодом и неоднородным профилем магнитного поля (2018)

AbstractThe possible formation of an extended low-energy state of electron beam in a coaxial diode with homogeneous cylindrical anode and moderate magnetic field with inhomogeneous profile is demonstrated for the first time. It is established that, depending on the magnetic field configuration, virtual cathodes (VCs) of two types can be formed: (i) a stationary VC with a localized reflection plane and (ii) a moving VC with a two-stream low-energy state of the electron beam.
GSG2 knockdown suppresses cholangiocarcinoma progression by regulating cell proliferation, apoptosis and migration (2020)

Abstract Background: Cholangiocarcinoma (CCA) is the second most common type of hepatocellular carcinoma with high aggressiveness and extremely poor prognosis. Homo sapiens germ cell associated 2 (GSG2) is a histone H3 threonine-3 kinase required for normal mitosis. Nevertheless, the role and mechanism of GSG2 in progression and development of CCA remain elusive. Methods: In the present study, correlation between GSG2 and CCA was elaborated by IHC, Mann-Whitney U and Spearman grading correlation. GSG2 knockdown cell lines were successfully constructed and further used to construct mouse xenotransplantation models. Subsequently, cell proliferation, cell apoptosis, cell cycle and cell migration were detected by MTT assay, Flow Cytometry and wound-healing assay, respectively. Results: It was demonstrated that GSG2 was overexpressed in CCA specimens and relevant cell lines. The statistical analysis determined that high GSG2 expression was positively associated with more advanced tumor grade. Importantly, GSG2 knockdown inhibited cell proliferation, migration, promoted cell apoptosis and arrested cell cycle in G2 phase. Meanwhile, in vivo results also supported that GSG2 knockdown inhibit tumor growth. Additionally, GSG2 was involved in CCA progression via suppressing EMT. Conclusions: In summary, our findings suggested that GSG2 may be a potential therapeutic target for CCA patients.
Catalytic Alkene Hydroboration Mediated by Cationic and Formally Zwitterionic Rhodium(I) and Iridium(I) Derivatives of a P,N-Substituted Indene (2006)

Cationic (2a,b) and formally zwitterionic (3a,b) Rh(I) and Ir(I) complexes supported by P,N-substituted indene or indenide ligands (respectively) have been employed in the selective hydroboration of substituted vinylarenes with pinacolborane (HBpin, pin = 1,2-O2C2Me4). Notably, 3a,b exhibited remarkably high, but differing, selectivities in the hydroboration of 1-phenylpropene.
Kisspeptin Neurons from Mice to Men: Similarities and Differences (2012)

The discovery that kisspeptin was critical for normal fertility in humans ushered in a new chapter in our understanding of the control of GnRH secretion. In this paper, we will review recent data on the similarities and differences across several mammalian species in the role of kisspeptin in reproductive neuroendocrinology. In all mammals examined to date, there is strong evidence that kisspeptin plays a key role in the onset of puberty and is necessary for both tonic and surge secretion of GnRH in adults, although kisspeptin-independent systems are also apparent in these studies. Similarly, two groups of kisspeptin neurons, one in the arcuate nucleus (ARC) and the other more rostrally, have been identified in all mammals, although the latter is concentrated in a limited area in rodents and more scattered in other species. Estrogen has divergent actions on kisspeptin expression in these two regions across these species, stimulating it the latter and inhibiting expression in the former. There is also strong evidence that the rostral population participates in the GnRH surge, whereas the ARC population contributes to steroid-negative feedback. There may be species differences in the role of these two populations in puberty, with the ARC cells important in rats, sheep, and monkeys, whereas both have been implicated in mice. ARC kisspeptin neurons also appear to participate in the GnRH surge in sheep and guinea pigs, whereas the data on this possibility in rodents are contradictory. Similarly, both populations are sexually dimorphic in sheep and humans, whereas most data in rodents indicate that this occurs only in the rostral population. The functional consequences of these species differences remain to be fully elucidated but are likely to have significance for understanding normal neuroendocrine control of reproduction as well as for use of kisspeptin agonists/antagonists as a therapeutic tool.
A study on practical fault location system for power transmission lines using neural networks (2002)

For the efficient operation of power transmission facilities, the authors have developed a new fault location (FL) system and put it to practical use. This system uses neural networks to analyze the distribution pattern of the current induced in overhead ground wires along the poser line. Improved reliability results from the introduction of fuzzy operation of input data, a fault-type decision method and an index expressing the reliability of the fault location result. These FL systems are installed in eight commercial lines, and run normally, one of which experienced a fault due to lightning and successfully located the fault point.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Approach to ingrowing toenails: The wedge resection/segmental phenolization combination treatment (1988)

One hundred and seventy procedures were performed on one hundred and forty patients with ingrowing toenails. Each patient was randomly allocated to one of three treatment groups. There were 55 wedge resections (WR), 53 segmental phenolizations (SP) and 62 wedge resection/segmental phenolization combination treatments (WR/SP). All patients were followed up for 6 months. The duration and intensity of postoperative pain was assessed and the recurrence rate monitored. Postoperative pain was less in the WR/SP group (9.4 +/- 13.5 h) than in the WR group (30.0 +/- 37.6 h, P less than 0.001). There were seven recurrences in the WR group, four in the SP group, and none in the WR/SP group. The results in the WR/SP group were statistically significant when compared with the WR group (P less than 0.01) and with the SP group (P less than 0.05). We conclude that the WR/SP combination procedure is a superior form of treatment for ingrowing toenails.
Immunomagnetic separation of infiltrating T lymphocytes from brain tumors (1989)

Tumor-infiltrating lymphocytes (TIL's) were isolated from human glioma biopsy specimens by immunomagnetic separation using T cell-specific monoclonal antibodies coupled to paramagnetic beads, and were expanded in culture with feeder cells and interleukin-2 (IL-2). The infiltrating cells from five of seven patients proliferated in culture. When tested after 2 to 3 weeks of culture, virtually all of the cells stained with antibodies against the CD2 and CD3 antigens. Most cells also expressed human leukocyte antigen class II molecules, while varying percentages of cells stained with antibodies against the IL-2 receptor and the CD4 and CD8 antigens. The cytotoxicity of the cultured TIL's against autologous and allogeneic glioma cells and the K562 and Daudi cell lines was measured and compared with that of lymphokine-activated killer (LAK) cells from the same patients. None of the TIL's showed significant cytotoxicity against these targets, whereas LAK cells lysed all of the targets.
False Adrenergic Transmitters (1968)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
Storage Active Service: Model, Method and Practice (2006)

For storage system, data service only passively responds to data consumer's requests. With the increasing requirements of mass data storage and the development of the hardware technology of computer architecture, storage active service becomes a crucial research topic. How to utilize the computation power on the future storage device to provide high performance computation and data access has been a hot and challenging task. Storage object is a fundamental unit that comprises not only data but also attributes. Storage object has been proposed in the past, but its definition should be extended. The goals of the storage active service project are to combine and distill previous work into a simple and usable model, design a storage active service mechanism as an understandable extension to object, and most importantly build a working system - a system that augments conventional structured and unstructured data management with data, attributes and trigger as an integral part of the storage object. This paper provides numerous motivating practices for storage active service and lays out preliminary plans for the forecast mechanism based on psychology
Self-compensation in phosphorus-doped CdTe (2017)

We investigate the self-compensation mechanism in phosphorus-doped CdTe. The formation energies, charge transition levels, and defect states of several P-related point defects susceptible to cause self-compensation are addressed by first-principles calculations. Moreover, we assess the influence of the spin-orbit coupling and supercell-size effects on the stability of AX centers, which are believed to be responsible for most of the self-compensation. We report an improved result for the lowest-energy configuration of the P interstitial $({\text{P}}_{\text{i}})$ and find that the self-compensation mechanism is not due to the formation of AX centers. Under Te-rich growth conditions, $({\text{P}}_{\text{i}})$ exhibits a formation energy lower than the substitutional acceptor $({\text{P}}_{\text{Te}})$ when the Fermi level is near the valence band, acting as compensating donor, while, for Cd-rich growth conditions, our results suggest that p-type doping is limited by the formation of $({\text{P}}_{\text{Te}}\ensuremath{-}{\text{V}}_{\text{Te}})$ complexes.
The Data Ring: Community Content Sharing (2007)

Information ubiquity has created a large crowd of users (most notably scientists), who could employ DBMS technology to process and share their data more effectively. Still, this user base prefers to keep its data in files that can be easily managed by applications such as spreadsheets, rather than deal with the complexity and rigidity of modern database systems. In this paper, we propose a vision for enabling non-experts, such as scientists, to build content sharing communities in a true database fashion: declaratively. The proposed infrastructure, called the data ring, enables users to manage and share their data with minimal effort; the user points to the data that should be shared, and the data ring becomes responsible for automatically indexing the data (to make it accessible), replicating it (for availability), and reorganizing its physical storage (for better query performance). We outline the salient features of our proposal, and outline research challenges that must be addressed in order to realize this vision. 1.
The ad wars (2017)

The increasing popularity of adblockers has prompted online publishers to retaliate against adblock users by deploying anti-adblock scripts, which detect adblock users and bar them from accessing content unless they disable their adblocker. To circumvent anti-adblockers, adblockers rely on manually curated anti-adblock filter lists for removing anti-adblock scripts. Anti-adblock filter lists currently rely on informal crowdsourced feedback from users to add/remove filter list rules. In this paper, we present the first comprehensive study of anti-adblock filter lists to analyze their effectiveness against anti-adblockers. Specifically, we compare and contrast the evolution of two popular anti-adblock filter lists. We show that these filter lists are implemented very differently even though they currently have a comparable number of filter list rules. We then use the Internet Archive's Wayback Machine to conduct a retrospective coverage analysis of these filter lists on Alexa top-5K websites over the span of last five years. We find that the coverage of these filter lists has considerably improved since 2014 and they detect anti-adblockers on about 9% of Alexa top-5K websites. To improve filter list coverage and speedup addition of new filter rules, we also design and implement a machine learning based method to automatically detect anti-adblock scripts using static JavaScript code analysis.
Interpretation of Magnetic Resonance Imaging for Locally Advanced Rectal Carcinoma After Preoperative Chemoradiation Therapy (2004)

Magnetic resonance imaging is commonly used in staging of pelvic malignancies because of its fine resolution, but chemoradiotherapy may decrease its accuracy. Thickening of the rectal wall after radiation by marked fibrosis, and peritumoral infiltration of inflammatory cells and vascular proliferation may contribute to overestimation of stage. By contrast, pathologic residual cancer beneath normal mural structure after chemoradiation therapy may result in understaging of rectal cancer.
Directed self-assembly of block copolymers for universal nanopatterning (2013)

Block copolymers (BCP) are self-assembling polymeric materials that have been extensively investigated for several decades. Recently, directed self-assembly (DSA) of BCPs has received enormous research attention from both academia and industry as next-generation nanolithography technology. This article provides a brief introduction to (i) the spontaneous and directed self-assembly of BCPs, (ii) the orientation and lateral ordering of BCP nanopatterns and their relationships with DSA strategies, (iii) various potential applications of BCP nanopatterning, and (iv) mussel-inspired BCP nanopatterning for arbitrary substrate materials including low surface energy materials.
Far from the eyes, close on the web (2012)

Online friendship connections are often not representative of social relationships or shared interest between users, but merely provide a public display of personal identity. A better picture of online social behaviour can be achieved by taking into account the intensity of communication levels between users, yielding useful insights for service providers supporting this communication. Among the several factors impacting user interactions, geographic distance might be affecting how users communicate with their friends. While spatial proximity appears influencing how people connect to each other even on the Web, the relationship between social interaction and spatial distance remains unexplored.
Thymidylate synthase predicts for clinical outcome in invasive breast cancer. (2005)

Thymidylate synthase (TS) is a major target of 5-fluorouracil (5-FU) and dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in the degradation of 5-FU. Whether TS or DPD could be used as valuable parameters for 5-FU sensitivity in clinical patients are largely unknown. We analyzed TS and DPD expression in breast carcinomas to evaluate the clinicopathological significance of these enzymes in patients with invasive breast cancer receiving 5-FU-based chemotherapy. A total of 197 patients with invasive ductal carcinoma were included in our study. Both the TS and DPD expression were analyzed using immunohistochemical method for all the surgical samples. Sixty-three out of 197 (31.97%) patients are positive for TS expression, and 77 out of 197 (39.09%) patients are positive for DPD expression. TS expression was not correlated with DPD expression. Patients with TS-positivity had aggressive phenotype including large tumor size, low differentiation and nodal metastasis. DPD expression is not related with phenotype or prognosis. Multivariate analysis demonstrated that TS expression was an independent prognostic factor for both disease-free and overall survival. The current study demonstrated that TS but not DPD expression was associated with both progression and prognosis in breast cancer receiving 5-FU-based chemotherapy. TS expression in the primary tumor might be useful as a predictive parameter for the efficacy of 5-FU-based chemotherapy for breast cancer.
A novel transgenic mouse model reveals deregulation of the ubiquitin‐proteasome system in the heart by doxorubicin (2005)

Ubiquitin-proteasome system (UPS) mediated proteolysis is responsible for the degradation of majority of cellular proteins, thereby playing essential roles in maintaining cellular homeostasis and regulating a number of cellular functions. UPS dysfunction was implicated in the pathogenesis of numerous disorders, including neurodegenerative disease, muscular dystrophy, and a subset of cardiomyopathies. However, monitoring in vivo functional changes of the UPS remains a challenge, which hinders the elucidation of UPS pathophysiology. We have recently created a novel transgenic mouse model that ubiquitously expresses a surrogate protein substrate for the UPS. The present study validates its suitability to monitor in vivo changes of UPS proteolytic function in virtually all major organs. Primary culture of cells derived from the adult transgenic mice was also developed and tested for their applications in probing UPS involvement in pathogenesis. Applying these newly established in vivo and in vitro approaches, we have proven in the present study that doxorubicin enhances UPS function in the heart and in cultured cardiomyocytes, suggesting that UPS hyper-function may play an important role in the acute cardiotoxicity of doxorubicin therapy.
Supplementary Table 8 from Definition of the Landscape of Promoter DNA Hypomethylation in Liver Cancer (2023)

&lt;p&gt;PDF file - 14K, List of genes derived from a comparison of demethylated genes between human liver, breast and ovarian cancers.&lt;/p&gt;
Τα έργα λανθασμένης πεποίθησης και η ικανότητα κατανόησης αφηγήσεων κατά την παιδική ηλικία (2020)

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Search and Detection (5th ed.) Workbook (2014)

This workbook is intended to accompany the text Search and Detection (5 ed.), by Alan Washburn.
How Effective is Anti-Phishing Training for Children? : (Distinguished Paper Award) (2017)

User training is a commonly used method for preventing victimization from phishing attacks. In this study, we focus on training children, since they are active online but often overlooked in interventions. We present an experiment in which children at Dutch primary schools received an anti-phishing training. The subjects were subsequently tested for their ability to distinguish phishing from non-phishing. A control group was used to control for external effects. Furthermore, the subjects received a re-test after several weeks to measure how well the children retained the training. The training improved the children's overall score by 14%. The improvement was mostly caused by an increased score on the questions where they had to detect phishing. The score on recognizing legitimate emails was not affected by the training. We found that the improved phishing score returned to pre-training levels after four weeks. Conversely, the score of recognition of legitimate emails increased over time. After four weeks, trained pupils scored significantly better in recognizing legitimate emails than their untrained counterparts. Age had a positive effect on the score (i.e., older children scored higher than younger ones); but sex had no significant influence. In conclusion, educating children to improve their ability to detect phishing works in the short term only. However, children go to school regularly, making it easier to educate them than adults. An increased focus on the cybersecurity of children is essential to improve overall cybersecurity in the future.
Mammographic risk assessment and local greylevel appearance histograms (2010)

It has been shown that the probability to develop breast cancer is strongly correlated with the appearance of tissue in mammographic images. This appearance incorporates both greylevel and tissue pattern aspects and models of local texture information, which incorporate both greylevel and spatial aspects, can as such be related to mammographic risk assessment. Here we represent texture by the variation in local greylevel configuration/appearance in histogram format for which the distribution varies with texture appearance. The histogram information can be directly used to classify mammograms according to standard mammographic risk estimation models (e.g. BIRADS). Results on the MIAS database indicate a correct classification of 70% (which increases to 84% for high/low risk classification), which is comparable with existing methods. Variation of the classification results with respect to some of the model parameters are discussed, which indicate the robustness of the methodology. In addition future directions, to improve the classification results are discussed.