gebhart/patrepeval huggingface dataset:
Induction of active autoimmunity to the murine CD20 extracellular domain protects mice from tumor challenge in a model of B cell lymphoma. (B158) (2007)

Abstract CD20 is a mostly B-cell restricted differentiation protein with a 40 amino acid extracellular domain (ECD) that has proven to be a clinically effective target for passive antibody therapy of B cell malignancies. Though there is interest in developing a mouse model to study the induction of active immunity to CD20, the CD20 ECD has significant secondary and tertiary structure which make it difficult to target with peptides. Our lab designs and studies the immunogenicity of recombinant immunogens which display peptides as tandemly repeated sequences. To target the CD20 ECD, we constructed and expressed a recombinant immunogen displaying six tandemly repeated copies of the N terminus of the murine CD20 ECD. Immunization of two inbred and one F1 strain of mice, and outbred rabbits, all led to the induction of antibodies reactive with the CD20 C-terminal peptide sequences by ELISA and more importantly, with native CD20 on the cell surface of the murine B cell lymphomas, A20 and 38-C13, by flow cytometry. The CD20-specific rabbit serum was also effective at immunoprecipitating CD20 from A20 cell lysate. Lastly, two independent experiments demonstrated that immunization of mice with the CD20 immunogen led to significant protection from a lethal challenge with the 38-C13 murine B cell lymphoma. Long term follow up of survivor mice demonstrated significant diminution of their auto antibody responses and no gross abnormalities.
Entanglement and Wigner Function Negativity of Multimode Non-Gaussian States (2017)

Non-Gaussian operations are essential to exploit the quantum advantages in optical continuous variable quantum information protocols. We focus on mode-selective photon addition and subtraction as experimentally promising processes to create multimode non-Gaussian states. Our approach is based on correlation functions, as is common in quantum statistical mechanics and condensed matter physics, mixed with quantum optics tools. We formulate an analytical expression of the Wigner function after the subtraction or addition of a single photon, for arbitrarily many modes. It is used to demonstrate entanglement properties specific to non-Gaussian states and also leads to a practical and elegant condition for Wigner function negativity. Finally, we analyze the potential of photon addition and subtraction for an experimentally generated multimode Gaussian state.
RESISTANCE OF METASTATIC PANCREATIC ENDOCRINE TUMOURS AFTER LONG‐TERM TREATMENT WITH THE SOMATOSTATIN ANALOGUE OCTREOTIDE (SMS 201–995) (1989)

Ten patients with metastatic pancreatic endocrine tumours were treated with the long-acting somatostatin analogue octreotide (SMS 201-995). Three patients showed no response, clinically or biochemically, and treatment was therefore withdrawn. The seven remaining patients continued treatment for a median period of 28 months (range 13-54 months). Treatment was initially effective, symptoms improved and the concentrations of tumour-related hormones were reduced. Worsening of symptoms and rising levels of tumour-related hormone concentrations occurred a median of 5 months (range 1-6 months) after the start of therapy and were initially reversed by increasing the dose of octreotide over a median of 10 months (range 6-16 months). However, after a median of 13 months (range 5-34 months) at the maximum dosage, symptoms recurred and were no longer responsive to a further increase in dosage of octreotide or other therapeutic measures. All patients died within a period of 5 months once this resistant phase of their illness had been reached.
Radiosurgery for the Treatment of Spinal Melanoma Metastases (2005)

Spinal radiosurgery offers a therapeutic modality for the safe delivery of large dose fractions of radiation therapy in a single fraction for the management of spinal metastases in patients with advanced melanoma that are often poorly controlled with alternative conventional external beam radiation therapy, and is successful even in patients with previously irradiated lesions.
Low‐Pressure GDS System (2007)

This chapter contains sections titled: State-of-the-Art Cold Spray Systems State-of-the-Art Powder Feeding Systems Modification of the Low-Pressure Portable GDS System An Industrial Low-Pressure Portable GDS System
Wideband Recording Technology for High-Definition Baseband VCRs (1987)

High-definition TV (HDTV: 1125 lines, 60 fields) is expected to be the next generation TV system. Fig. 1 shows a block diagram of the HDTV system. In Japan, a HDTV broadcast service using a broadcasting satellite will start in the near future. The signal, transmitted through one satellite television channel, is a bandwidth-compressed HDTV signal, called a MUSE signal.(1) Bandwidth of the MUSE signal is 8.1MHz, i.e. about 2 times that of conventional TV signals. MUSE VCRs, which record this signal, have already been developed experimentally (Fig.1(a)).(2)~(4)
Fabrication and physics of 2 nm islands for single electron devices (1995)

Multiple tunneling junctions consisting of metal islands about 2 nm in diameter and &amp;lt;2 nm gaps were fabricated by a combination of high resolution electron-beam lithography and an ionized beam deposition technique. The effective tunneling capacitance of this structure is calculated to be about 0.2 aF, implying that the charging energy associated with an electron tunneling on or off the islands is well above the thermal energy at room temperature. Electrical measurements showed clear Coulomb blockade effects in this structure. Coulomb gaps of 0.16 V were observed at 77 K in the source–drain current–voltage characteristics and the nonlinearity persisted up to room temperature although the Coulomb gaps disappeared as the temperature was raised. When the voltage applied to the gate electrode was swept, the drain–source current showed strong oscillations at constant drain–source bias voltage, confirming the existence of single electron charging effects. This process can be used to fabricate single electron devices operating at liquid nitrogen temperature or perhaps even at room temperature and is compatible with the methods used in integrated circuit processes.
Catalytic Activity of Activated Carbon Prepared from Active Sludge Waste for NO-NH3 Reaction at Ambient Temperatures. (1993)

Catalytic activity of an active carbon produced from active sludge waste for the reduction of NO (400ppm) in air with NH3 at a temperature range of 25 to 250°C, examining influences of humidity in air. The active carbon (R-MGAC) exhibited a remarkable stationary activity in comparison with the conventional active carbons, providing a conversion of 90% in dry air at 25°C by W/F of 5×10-3g·min/ml. Further heattreatment in N2 at 800°C reduced significantly the activity. Activation with H2SO4 (R-MGAC-S (3/400/4) increased slightly the activity in dry air. Humidity in air above 60% at 25°C decreased the activity of R-MGAC, providing a conversion of 12and 4% under 70 and 100% humidity which were about one seventh and one twentyth of that in dry air, respectively. Heattreatment at 800°C and H2SO4 treatment improved the activity in wet air, providing higher conversions of 36 and 42%, respectively under 70% humidity and 20 and 10% under 100% humidity, respectively at 25°C, although retardation by humidity was still marked. The higher reaction temperature up to 100°C de-creased the conversion in dry air but increased that in humid air. The conversion in both dry and wet air increased at higher temperatures than 100°C. Temperature programmed decomposition analysis of R-MGACs exhibited CO2 evolution at two temperature ranges of 200-450°C and 450-900°C. H2SO4 treatment increased very significantly the evolution at the first range, and the heattreatment decreased very much the evolution at the both ranges. The former treatment may enhance the activity in wet air through the more adsorption of NH3, while the latter treatment does through removal of hydrophilic groups. Remarkable activities before H2SO4 activation and significant presence of nitrogen are common to the present active carbon and the polyacrylonitrile based activated carbon fiber (PAN-ACF) in a previous paper. Participation of nitrogen group in their catalytic performance is commonly postulated, although humidity was prohibited completely the activity of the fiber.
Inverse Q -filter for seismic resolution enhancement (2006)

Abstract A principal limitation on seismic resolution is the earth attenuation, or Q-effect, including the energy dissipation of high-frequency wave components and the velocity dispersion that distorts seismic wavelets. An inverse Q-filtering procedure attempts to remove the Q-effect to produce high-resolution seismic data, but some existing methods either reduce the S/N ratio, which limits spatial resolution, or generate an illusory high-resolution wavelet that contains no more subsurface information than the original low-resolution data. In this paper, seismic inverse Q-filtering is implemented in a stabilized manner to produce high-quality data in terms of resolution and S/N ratio. Stabilization is applied to only the amplitude compensation operator of a full inverse Q-filter because its phase operator is unconditionally stable, but the scheme neither amplifies nor suppresses high frequencies at late times where the data contain mostly ambient noise. The latter property makes the process invertible, differentiating from some conventional stabilized inverse schemes that tend to suppress high frequencies at late times. The stabilized inverse Q-filter works for a general earth Q-model, variable with depth or traveltime, and is more accurate than a layered approach, which involves an approximation to the amplitude operator. Because the earth Q-model can now be defined accurately, instead of a constant-Q layered structure, the accuracy of the inverse Q-filter is much higher than for a layered approach, even when implemented in the Gabor transform domain. For the stabilization factor, an empirical relation is proposed to link it to a user-specified gain limit, as in an explicit gain-controlling scheme. Synthetic and real data exam-ples demonstrate that the stabilized inverse Q-filter corrects the wavelet distortion in terms of shape and timing, compensates for energy loss without boosting ambient noise, and produces desirable seismic images with high resolution and high S/N ratio.
A new method of reduced order feedback control using Genetic Algorithms (1999)

Genetic Algorithms (GAs) have been applied as an effective optimization search technique in various fields, including the field of control design. In this paper, a new control method using GAs is proposed to attenuate the responses of a structure under seismic excitation. The proposed controller uses the state space reconstruction technique based on the embedding theorem to obtain full state performance from the available reduced order feedback. The parameters of the new controller are optimized using GAs. The proposed GA-based control method is verified on a benchmark problem—active mass driver system—and the results are compared with other control methods. The robustness of the proposed control method is also examined. Copyright © 1999 John Wiley & Sons, Ltd.
Delibration on service quality evaluation of internet banking by using ES-Qual, a Case study in an Iranian Bank (2015)

Nowadays, Due to the increasing development of Internet and communication services, Manufacturers and suppliers have been found the special importance of the Internet and use it to offer its services. In this study, using the model ES-Qual (E-SQ), internet banking service quality in an Iranian bank in four dimensions "Efficiency (Eff), system availability (Sys), Fulfillment (Ful), privacy (Pri)" is discussed. In the event of difficulties in internet banking transactions in order to solve the problems and doing it timely, appropriate and suitable for protection of people privacy, some Criterias are considered in this model called "Responsivness (Res), Compensation (Com), contact (Con)".In this study, the kind of research is applied research and research methods are descriptive and inferential (correlation), The population in This research is bank customers in Tehran, which use of internet banking.Gathering information from books and magazines and the analysis of data, the questionnaire and interview preparation and descriptive and inferential statistics (correlation analysis) were used.Questionnaire survey, distribute randomly between internet banking customers electronically and manually distributed, to analyze data and software regression Lisrel, in both descriptive and inferential statistics were used.Â Keywords: Internet banking services, quality of service, ES-QUAL, Internet.
Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy Reveals the Existence of Two Gates for Ion Conduction (2006)

The closed KcsA channel structure revealed a crossing of the cytosolic ends of the transmembrane helices blocking the permeation pathway. It is generally agreed that during channel opening this helical bundle crossing has to widen in order to enable access to the inner cavity. Here, we address the question of whether the opening of the inner gate is sufficient for ion conduction, or if a second gate, located elsewhere, may interrupt the ion flow. We used fluorescence lifetime measurements on KcsA channels labeled with tetramethylrhodamine at residues in the C-terminal end of TM2 to report on the opening of the lower pore region. We found two populations of channels with different fluorescence lifetimes, whose relative distribution agrees with the open probability of the channel. The absolute fraction of channels found with an open bundle crossing is too high to explain the low open probability of the KcsA-WT channel. We found the same distribution as in the WT channel between open and closed bundle crossing for two KcsA mutants, A73E and E71A, which significantly increase open probability at low pH. These two results strongly suggest that a second gate in the ion permeation pathway exists. The location of the mutations A73E and E71A suggests that the second gate may be the selectivity filter, which resides in an inactivated state under steady-state conditions. Since the long closed times observed in KcsA-WT are not present in KcsA-A73E or -E71A, we propose that KcsA-WT remains predominantly in a state with an open bundle crossing but closed (inactivated) second gate, while the mutations A73E and E71A sharply decrease the tendency to enter in the inactivated state, and as a consequence, the second gate is predominantly open at steady state. The ability to monitor the opening of the bundle crossing optically enables the direct recording of the movement of the pore helices while the channel is functioning.
语言分析哲学的魅力——与贝特兰·威廉斯的对话 (1986)

引论玛吉;“语言分析哲学”和“语言分析”是指同一件事;主要是指在英国发展起来的哲学技巧。这种技巧发展到四十和五十年代已卓有成就了。我想,几乎每个从那时起就从事哲学研究的人都受到了它的影响。两个最主要的活动中心是牛津和剑桥大学。在牛津,最有影响的人物是J·L奥斯汀,其次是吉尔伯特·赖尔,而在剑桥,无与伦比的人物是维特
Site-Specific Integration in Mammalian Cells Mediated by a New Hybrid Baculovirus–Adeno-Associated Virus Vector (1998)

Baculovirus can transiently transduce primary human and rat hepatocytes, as well as a subset of stable cell lines. To prolong transgene expression, we have developed new hybrid vectors which associate key elements from adeno-associated virus (AAV) with the elevated transducing capacity of baculovirus. The hybrid vectors contain a transgene cassette composed of the beta-galactosidase (beta-Gal) reporter gene and the hygromycin resistance (Hygr) gene flanked by the AAV inverted terminal repeats (ITRs), which are necessary for AAV replication and integration in the host genome. Constructs were derived both with and without the AAV rep gene under the p5 and p19 promoters cloned in different positions with respect to the baculovirus polyheidrin promoter. A high-titer preparation of baculovirus-AAV (Bac-AAV) chimeric virus containing the ITR-Hygr-beta-Gal sequence was obtained with insect cells only when the rep gene was placed in an antisense orientation to the polyheidrin promoter. Infection of 293 cells with Bac-AAV virus expressing the rep gene results in a 10- to 50-fold increase in the number of Hygr stable cell clones. Additionally, rep expression determined the localization of the transgene cassette in the aavs1 site in approximately 41% of cases as detected by both Southern blotting and fluorescent in situ hybridization analysis. Moreover, site-specific integration of the ITR-flanked DNA was also detected by PCR amplification of the ITR-aavs1 junction in transduced human fibroblasts. These data indicate that Bac-AAV hybrid vectors can allow permanent, nontoxic gene delivery of DNA constructs for ex vivo treatment of primary human cells.
A fast and accurate method to measure the radiation characteristics of probe-fed circularly-polarized antennas in Mm-wave bands (2012)

In this paper, we propose a fast method to measure the radiation characteristics of probe-fed circularly polarized antennas operating in Mm-wave bands. The axial ratio of such antennas can be computed in any particular space direction (θ,φ) from four measurement points in a very short time. It can be also given for the whole quasi-3D sphere in 2 ½ hours (2° θ step, 10° φ step). A 7 dBi gain antenna designed on a PCB substrate is fabricated for illustrating this method. Reported results show a really good match between simulation and measurements.
Electrodeposition of Metals (2008)

This chapter contains sections titled: Electrodeposition in AlCl3-based Ionic Liquids Electrodeposition of Metals in Air- and Water-stable Ionic Liquids Deposition of Metals from Non-chloroaluminate Eutectic Mixtures Troublesome Aspects References
Catalytic Asymmetric Rearrangement of Allylic N‐Aryl Trifluoroacetimidates. A Useful Method for Transforming Prochiral Allylic Alcohols to Chiral Allylic Amines. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Insurance-Based Disparities in Congenital Cardiac Operations in the Era of the Affordable Care Act (2023)

A body of literature has previously highlighted the impact of health insurance on observed disparities in congenital cardiac operations. With aims of improving access to healthcare for all patients, the Affordable Care Act (ACA) expanded Medicaid coverage to nearly all eligible children in 2010. Therefore, the present population-based study aimed to examine the association of Medicaid coverage with clinical and financial outcomes in the era the ACA. Records for pediatric patients (≤ 18 years) who underwent congenital cardiac operations were abstracted from the 2010-2018 Nationwide Readmissions Database. Operations were stratified using the Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) Category. Multivariable regression models were developed to evaluate the association of insurance status on index mortality, 30-day readmissions, care fragmentation, and cumulative costs. Of an estimated 132,745 hospitalizations for congenital cardiac surgery from 2010 to 2018, 74,925 (56.4%) were insured by Medicaid. The proportion of Medicaid patients increased from 57.6 to 60.8% during the study period. On adjusted analysis, patients with Medicaid insurance were at an increased odds of mortality (1.35, 95%CI: 1.13-1.60) and 30-day unplanned readmission (1.12, 95%CI: 1.01-1.25), experienced longer lengths of stay (+ 6.5 days, 95%CI 3.7-9.3), and exhibited higher cumulative hospitalization costs (+ $21,600, 95%CI: $11,500-31,700). The total hospitalization cost-burden for patients with Medicaid and private insurance were $12.6 billion and $8.06 billion, respectively. Medicaid patients exhibited increased mortality, readmissions, care fragmentation, and costs compared to those with private insurance. Our results of outcome variation by insurance status indicate the necessity of policy changes to attempt to approach equality in surgical out comes for this high-risk cohort. Baseline characteristics, trends, and outcomes by insurance status over the ACA rollout period 2010-2018.
Radio Frequency Interference from Near-Earth Satellites (1977)

A pessimistic statistical model was developed for predicting the extent of radio frequency interference (RF1). Based on the assumptions underlying the model, DSN S-band operations can expect one RF1 interruption every 4.1 days, with the average incident lasting 24 s. This implies that 52 or more such satellites, with uncorrelated orbital trajectories, will cause in excess of 5 min of RF1 per day at a DSN station.
Sulfur-Containing Palladacycles:  Efficient Phosphine-Free Catalyst Precursors for the Suzuki Cross-Coupling Reaction at Room Temperature (2000)

[reaction: see text] Cyclopalladated compounds derived from the ortho-metalation of benzylic tert-butyl thioethers are excellent catalyst precursors for the Suzuki cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under mild reaction conditions. A broad range of substrates and functional groups are tolerated in this protocol, and highly catalytic activity is attained.
Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells (2022)

Insulin secretion in pancreatic β-cells is regulated by cortical complexes that are enriched at the sites of adhesion to extracellular matrix facing the vasculature. Many components of these complexes, including bassoon, RIM, ELKS and liprins, are shared with neuronal synapses. Here, we show that insulin secretion sites also contain the non-neuronal proteins LL5β (also known as PHLDB2) and KANK1, which, in migrating cells, organize exocytotic machinery in the vicinity of integrin-based adhesions. Depletion of LL5β or focal adhesion disassembly triggered by myosin II inhibition perturbed the clustering of secretory complexes and attenuated the first wave of insulin release. Although previous analyses in vitro and in neurons have suggested that secretory machinery might assemble through liquid-liquid phase separation, analysis of endogenously labeled ELKS in pancreatic islets indicated that its dynamics is inconsistent with such a scenario. Instead, fluorescence recovery after photobleaching and single-molecule imaging showed that ELKS turnover is driven by binding and unbinding to low-mobility scaffolds. Both the scaffold movements and ELKS exchange were stimulated by glucose treatment. Our findings help to explain how integrin-based adhesions control spatial organization of glucose-stimulated insulin release.
Tick Transmission of Anaplasma marginale (2012)

Anaplasma marginale is a globally prevalent pathogen of cattle transmitted by Ixodid ticks. Understanding the complex development of A. marginale in the tick vector will allow for better prediction of disease outbreaks and will afford opportunities for control of disease transmission. The basic developmental cycle of A. marginale in the tick is reviewed here along with recent studies exploiting differences in transmission between strains to delineate aspects of the interaction between the pathogen and the vector. Bacterial, protozoan, and viral pathogens transmitted by arthropod vectors result in severe disease in animals and humans. Despite their impact, these infections remain poorly controlled with primary reliance on acaricides to block tick transmission. The rapid emergence of tick resistance to multiple acaricides threatens this control and has resulted in a resurgence of research to develop novel strategies for control. Novel approaches to preventing tick-borne transmission of livestock pathogens will result from understanding the interaction between the pathogen and the tick, a process that culminates with development of infectivity and successful transmission. In all of the tick-transmitted pathogens, development of pathogen infectivity is coordinated with attachment and feeding of the tick upon the animal. This is clearly dependent upon signaling between the feeding vector and the pathogen and thus susceptible to intervention.