gebhart/patrepeval huggingface dataset:
Concentration of 99mTc-pertechnetate and 188Re-perrhenate (2006)

Summary The radioactive concentrations of 99m Tc/ 188 Re from their generators are dependent upon the specific activity of 99 Mo/ 188 W, which dictates the bed size of the alumina/gel column and the volume of physiological saline needed as eluent. Because of the high content of inactive molybdenum/tungsten in neutron irradiated MoO 3 /WO 3 , large columns containing alumina/gel are needed to produce chromatographic 99 Mo → 99m Tc/ 188 W → 188 Re generators. This results in large elution volumes containing relatively high 99 Mo/ 188 W contents and low concentrations of 99m Tc/ 188 Re. The decrease in radioactive concentration, or specific volume, places a limitation on some of the clinical procedures. We report post elution concentration of 99m Tc/ 188 Re using in house prepared silver cation exchange and alumina column. The high bolus volumes (10 − 60 ml saline) can conveniently be concentrated in 1 ml of saline. This approach also works very effectively to yield high specific volume solutions of 99m Tc-pertechnetate from a fission 99 Mo loaded alumina generator towards the end of its normal working life.
Quantum Simulation: How Quantum Computers will Help us Resolve Matters of Substance. (2021)

Abstract not provided.
Potentiometric pH Sensor Based on Flexible Screen-Printable Polyaniline Composite for Textile-Based Microfluidic Applications (2022)

Skin pH can be used for monitoring infections in a healing wound, the onset of dermatitis, and hydration in sports medicine, but many challenges exist in integrating conventional sensing materials into wearable platforms. We present the development of a flexible, textile-based, screen-printed electrode system for biosensing applications, and demonstrate flexible polyaniline (PANI) composite-based potentiometric sensors on a textile substrate for real-time pH measurement. The pH response of the optimized PANI/dodecylbenzene sulfonic acid/screen-printing ink composite is compared to electropolymerized and drop-cast PANI sensors via open circuit potential measurements. High sensitivity was observed for all sensors between pH 3-10, with a composite based on PANI emeraldine base, demonstrating sufficient response time and a linear sensitivity of -27.9 mV/pH. This exceeded prior flexible screen-printed pH sensors in which all parts of the sensor, including the pH sensing material, are screen-printed. Even better sensitivity was observed for a PANI emeraldine salt composite (-42.6 mV/pH), although the response was less linear. Furthermore, the sensor was integrated into a screen-printed microfluidic channel demonstrating sample isolation during measurement for wearable, micro cloth-based analytical devices. This is the first fully screen-printed flexible PANI composite pH sensor demonstrated on a textile substrate that can additionally be integrated with textile-based microfluidic channels.
Purification ofTrypanosoma bruceivariable surface glycoproteins: analysis of degradation occurring during isolation (1982)

Trypanosoma brucei variable surface glycoproteins (VSGs), isolated from some antigenic types of trypanosomes, degraded during isolation. We show that this degradation occurred immediately after breakage of the organism, presumably because of liberation of internal enzymes, and resulted in heterogeneity of isolated VSGs with respect to charge and/or molecular weight. Degradation and consequent heterogeneity of these VSGs could be abolished by releasing VSG from the trypanosome surface without breakage of the organism. The method was a modification of an incubation and shaking procedure initially described for Trypanosoma congolense (Reinwald, Rautenberg & Risse, 1979). WaTat 1.11 VSG released by this method and isolated, had a molecular weight (mol.wt) of 63000 and bound to a heterologous anti-VSG serum. VSG isolated from the same trypanosomes following breakage of organisms was of lower molecular weight. One such WaTat 1.11 VSG fragment of 42000 mol. wt, did not bind to the heterologous anti-VSG serum and therefore lacked cross-reacting antigenic determinants present in the 63000 mol. wt VSG.
5PM1-C-2 On-chip in vitro model replicating metabolism pathway (2013)

In this research, we propose an on-chip in vitro model based on a microfluidic device for pharmacokinetic studies. To construct an in vitro pharmacokinetic model that appropriately models in vivo conditions, physiological parameters such as the structure of internal circulation and volume ratios of each of the organs were mimicked using microfluidic networks. Pharmacokinetic study using tegafur was conducted to model the effects of biologically activate anticancer drugs. The efficacy of the anticancer drug in the target cells was successfully demonstrated using the device. This device can thus be used as an in vitro organ model to predict the pharmacokinetics of drugs in the human body.
Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: A potential treatment strategy for Epstein-Barr virus-positive Hodgkin's lymphoma (2001)

The EBV-encoded LMP2A protein is consistently expressed in EBV(+) Hodgkin's lymphoma and can be targeted by CTLs. CTLs stimulated conventionally by LCLs have little activity against LMP2A(+) target cells. Here, we describe an alternative approach, based on the in vitro stimulation of CTLs with DCs genetically modified with 2 E1/E3-deleted recombinant adenoviruses, AdGFPLMP2A, encoding a fusion gene of GFP and LMP2A, and AdLMP2A, encoding LMP2A only. Transduction of DCs with AdGFPLMP2A at MOI 1,000 resulted in LMP2A expression in up to 88% of DCs. LMP2A protein was expressed in 40% of DCs transduced with AdLMP2A at an MOI of 100. Higher MOI resulted in DC death. CTL lines activated by transduced DCs had a higher frequency of LMP2A tetramer-specific CTLs than CTL lines activated by LCLs. CTLs stimulated with transduced DCs lysed both autologous fibroblasts infected with vaccinia virus LMP2A (FBvaccLMP2A) and autologous LCLs, which express LMP2A at lower levels. In contrast, CTLs generated from the same donors by stimulation with autologous LCLs showed minimal lysis of FBvaccLMP2A. Moreover, 1 donor who did not respond to LMP2A when CTLs were stimulated with LCLs became a responder when LMP2A was expressed by transduced DCs. Hence, recombinant adenoviruses encoding LMP2A effectively transduce DCs and direct the generation of LMP2A-specific CTLs. This approach will be a potent strategy in Hodgkin's lymphoma immunotherapy.
Effect of uniaxial stress fields on the domain selection of epitaxial ferroelectric films (1999)

Abstract The effect of uniaxial external stress fields applied during the cooling down from the deposition temperature on the domain structure of epitaxial ferroelectric or ferroelastic films is investigated using the domain stability map. This map predicts stable domain structures and is constructed in the coordinates of the misfit strain between the cubic substrate and the film, and the tetragonality of the film. It is shown that with the application of a stress field perpendicular to the film-substrate interface, perfectly c-axis oriented films may be obtained.
Real-time economic dispatch and reserve allocation using merit order loading and linear programming rules (1989)

The author presents a real-time economic dispatch algorithm suitable for online generation control and for study programs. The method is based on the rules of linear programming and the classical method of merit order loading. The basis for the algorithm is shown as a natural progression of classical optimization algorithms. Comparison with linear programming is included to exhibit the flexibility of the algorithm. The inclusion of a constraint for a unit or for a system-wide margin (e.g. spinning reserve) is shown. The procedure is fast, in part because the simplex tableau is not explicitly stored. The method is shown in pseudo-code. This method is very suitable for real-time economic dispatch on any energy management system. The method requires little computer resource and is appropriate for personal-computer implementation as part of a back-up automatic generation control system. The algorithm has been tested on data provided by Indianapolis Power and Light Company and has been programmed on a 80286 personal computer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells (2011)

Resveratrol is a polyphenolic phytoestrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory, and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activities result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis and osteoporosis. Receptor activator of NF-κB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study, we investigated the effects of resveratrol on RANKL during bone morphogenesis in high density bone cultures in vitro. Untreated bone-derived cell cultures produced well organized bone-like structures with a bone-specific matrix. Treatment with RANKL induced formation of tartrate-resistant acid phosphatase-positive multinucleated cells that exhibited morphological features of osteoclasts. RANKL induced NF-κB activation, whereas pretreatment with resveratrol completely inhibited this activation and suppressed the activation of IκBα kinase and IκBα phosphorylation and degradation. RANKL up-regulated p300 (a histone acetyltransferase) expression, which, in turn, promoted acetylation of NF-κB. Resveratrol inhibited RANKL-induced acetylation and nuclear translocation of NF-κB in a time- and concentration-dependent manner. In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and preosteoblastic cells, leading to deacetylation of RANKL-induced NF-κB, inhibition of NF-κB transcriptional activation, and osteoclastogenesis. Co-treatment with resveratrol activated the bone transcription factors Cbfa-1 and Sirt-1 and induced the formation of Sirt-1-Cbfa-1 complexes. Overall, these results demonstrate that resveratrol-activated Sirt-1 plays pivotal roles in regulating the balance between the osteoclastic versus osteoblastic activity result in bone formation in vitro thereby highlighting its therapeutic potential for treating osteoporosis and rheumatoid arthritis-related bone loss.
A survey on prioritization regression testing test case (2017)

Regression testing is a process used to measure the validity of the system during software maintenance. Regression testing process is very expensive and must be introduced each time a modification occurs in software to ensure that the system still work and that the new modification doesn't cause any bugs, this process depends on selecting test cases from a test suite. Selection of test cases is very critical since it affect the regression testing time and effort, so that many algorithms exist to enhance regression testing process. One of the methods used to make enhancements is to select test cases using prioritization testing techniques. Prioritization techniques find the bugs early to improve regression testing efficiency by prioritizing the test cases. In this paper many regression testing prioritization techniques were reviewed and analyzed.
Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain (2015)

Effective assessment and management of wound pain can facilitate both improvements in healing rates and overall quality of life. From a pharmacological perspective, topical application of nonsteroidal anti-inflammatory drugs in the form of film wound dressings may be a good choice. Thus, the aim of this work was to develop novel layered film wound dressings containing ibuprofen based on partially substituted fibrous sodium carboxymethylcellulose (nonwoven textile Hcel NaT). To this end, an innovative solvent casting method using a sequential coating technique has been applied. The concentration of ibuprofen which was incorporated as an acetone solution or as a suspension in a sodium carboxymethylcellulose dispersion was 0.5 mg/cm(2) and 1.0 mg/cm(2) of film. Results showed that developed films had adequate mechanical and swelling properties and an advantageous acidic surface pH for wound application. An in vitro drug release study implied that layered films retained the drug for a longer period of time and thus could minimize the frequency of changing the dressing. Films with suspended ibuprofen demonstrated higher drug content uniformity and superior in vitro drug release characteristics in comparison with ibuprofen incorporation as an acetone solution. Prepared films could be potential wound dressings for the effective treatment of wound pain in low exuding wounds.
S2S architecture and faceted browsing applications (2012)

This demo paper will discuss a search interface framework designed as part of the Semantic eScience Framework project at the Tetherless World Constellation. The search interface framework, S2S, was designed to facilitate the construction of interactive user interfaces for data catalogs. We use Semantic Web technologies, including an OWL ontology for describing the semantics of data services, as well as the semantics of user interface components. We have applied S2S in three different scenarios: (1) the development of a faceted browse interface integrated with an interactive mapping and visualization tool for biological and chemical oceanographic data, (2) the development of a faceted browser for more than 700,000 open government datasets in over 100 catalogs worldwide, and (3) the development of a user interface for a virtual observatory in the field of solar-terrestrial physics. Throughout this paper, we discuss the architecture of the S2S framework, focusing on its extensibility and reusability, and also review the application scenarios.
The current status of silicon-on-insulator technologies - a comparison (1986)

This paper reviews the advantages of silicon-on-insulator (SOI) integrated circuits for a number of important application areas, placing particular emphasis on MOS technology. The most promising of the current contending techniques for substrate preparation, including oxygen ion implanted silicon (SIMOX), recrystallised polycrystalline silicon using the zone melting approach (ZMR), oxidised porous silicon, and epitaxial silicon-on-sapphire (SOS) are considered, and their current status in respect of materials properties, device and circuit performance are summarised.
Molecular Mechanism of Type I Congenital Heparin Cofactor (HC) II Deficiency Caused by a Missense Mutation at Reactive P2 Site: HC II Tokushima (2001)

We found a 66-year-old Japanese patient with type I congenital heparin cofactor (HC) II deficiency manifesting multiple atherosclerotic lesions. To investigate the molecular pathogenesis of our patient, we performed sequencing analysis and expressed recombinant human wild-type and mutant HC II molecules in COS-1 and CHO-K1 cells. Sequencing analysis following amplification of each of all 5 exons and its flanking region showed a single C to T transition at nucleotide position 12,854 in exon 5, which changed a Pro443 codon (CCG) to Leu codon (CTG). Because this mutation generates a new Bhv I site, the Bbv I digestion pattern of the PCR-amplified exon 5 fragments from each family member was analyzed. In all cases, the patterns were consistent with the activities and antigen levels of plasma HC I1 in those members. Transient transfection, metabolic labeling and pulse-chase experiments followed by immunoprecipitation analysis showed that the recombinant mutant HC II molecules were secreted from COS-1 cells in reduced amounts compared with the wild-type, and that an enhanced intracellular association of the mutant molecules with a chaperone, GRP78/BiP, was observed in CHO-K1 cells. Northern blot analysis indicated that the mutant HC I1 mRNA was transcribed at a similar level as that of wild-type. Immunohistochemical staining of the transfected cells revealed that COS-1 cells expressing the mutant HC II molecules were stained mainly in the perinuclear area. We conclude that the impaired secretion of the mutant HC II molecules, due to intracellular degradation, is the molecular pathogenesis of type I congenital HC II deficiency caused by a Pro443 to Leu mutation at reactive P2 site.
Reduced Equations of Motion for Generalized Fluxes and Forces in the Continued-Fraction Expansion (1980)

With the aid of Mori's projection operator method, it is shown that the mechanical equations of motion for flux variables can be transformed rigorously into the reduced form da, (t) / dt=iliJr a1 (t)- J: ds [,P1 (t-s) + ¢1 (t-s)] · a1 (s) + g1 (t) + jj(t), where a, (t) is a column matrix of generalized fluxes standing for the j·th order time derivative of the column matrix of state variables a, (t), <Po (t) =0, g0 (t) =0 and liJ1 is a frequency matrix. jj(t) is Mori's j·th order random force and ¢1 (t) is the corresponding memory matrix. A new fluctuating force g1 (t) and the corresponding memory matrix cf;1 (t) represent the effects of lower· order fluxes. The temporal behaviour of g 1 (t) is quite different from that of jj(t), and the Laplace transform of cf;1 (t) is represented by an inverted continued fraction of finite order whose poles are all purely imaginary. The Laplace transform of time· correlation matrices of a1 (t) and a. (0) are given in terms of these memory·spectrum matrices cf;1 [z] and ¢1 [z].
Linker-free antibody conjugation for sensitive hydrogel microparticle-based multiplex immunoassay (2019)

Multiplex immunoassay, or the simultaneous detection of multiple proteins in a single sample, is expected to enable a new level of protein analysis across diverse disciplines, such as medical diagnostics and biomarker discovery. A bead-based assay using graphically encoded hydrogel microparticles synthesized using stop flow lithography has been a promising platform because of its high multiplex capacity and its superior sensitivity and dynamic range compared to the enzyme-linked immunosorbent assay (ELISA). The functionalization of these particles has been dependent on the use of a heterobifunctional linker to conjugate the capture antibodies on the hydrogel. However, the linker chemistry, which is based on linking the primary amine groups of antibodies with acrylate functional groups on the hydrogel monomer, is vulnerable to hydrolysis in aqueous conditions and can potentially damage the antigen binding region of the antibody. In this work, we introduce a new antibody conjugation method that avoids the use of the linker and further enhances the sensitivity of hydrogel microparticle-based immunoassays. Disulfide bonds in antibodies are reduced to liberate free thiols, which can directly bond with the double bonds remaining in the hydrogel after particle synthesis. We characterize the optimal reduction of antibodies for producing the highest detection signal and demonstrate an average two-fold improvement in sensitivity compared to the linker-dependent antibody conjugation method. Lastly, we validate the accuracy and specificity of the multiplex assays with particles conjugated with antibodies using the linker-free method.
Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes. (2002)

Rop depressed INa and ICa-L, which may be related to its cardiotoxic effect
Evaluation of Anesthetic Specific EEG Dynamics during State Transitions between Loss and Return of Responsiveness (2021)

our results highlight substance-specific differences in the emergence from anesthesia that can influence the EEG-based monitoring that probably have to be considered in order to improve neuromonitoring during general anesthesia.
Gorenstein, David G.: Developments in31P NMR (2007)

The sections in this article are 1 Other Important 31 P Milestones 2 Conclusions 3 Biographical Sketch
Tension pneumocephalus following cranioplasty with a titanium plate: a case report (2022)

Tension pneumocephalus (TP) can be a life-threatening postoperative complication, but there are limited data owing to its exceedingly low frequency. A 48-year-old man that suffered a head injury survived the acute phase and cranioplasty was performed using a titanium plate. Progressive deterioration of consciousness occurred the day after the cranioplasty. Computed tomography showed the presence of expanded air in the left epidural cavity and a midline shift to the right side. Emergency skin flap reopening was performed. Tension of the scalp decreased when the skin suture was cut and the wound reopened. Lucidity and improved right hemiparesis were obtained within a few hours after drain insertion. Pooled air in the left epidural cavity gradually dissipated postoperatively and the epidural drain was removed 2 days after insertion. The patient was discharged 27 days after cranioplasty, with a modified Rankin scale score of 2. The mechanism that caused TP was considered. Specifically, the skin flap acted as a one-way valve and trapped air. Then the trapped air expanded as the patient's body temperature warmed. TP should be considered a differential diagnosis after craniotomy. Emergency skin flap reopening and drain insertion may be an effective treatment for TP in the epidural space.
Entity resolution on-demand (2022)

Entity Resolution (ER) aims to identify and merge records that refer to the same real-world entity. ER is typically employed as an expensive cleaning step on the entire data before consuming it. Yet, determining which entities are useful once cleaned depends solely on the user's application, which may need only a fraction of them. For instance, when dealing with Web data, we would like to be able to filter the entities of interest gathered from multiple sources without cleaning the entire, continuously-growing data. Similarly, when querying data lakes, we want to transform data on-demand and return the results in a timely manner---a fundamental requirement of ELT ( Extract-Load-Transform ) pipelines. We propose BrewER , a framework to evaluate SQL SP queries on dirty data while progressively returning results as if they were issued on cleaned data. BrewER tries to focus the cleaning effort on one entity at a time, following an ORDER BY predicate. Thus, it inherently supports top-k and stop-and-resume execution. For a wide range of applications, a significant amount of resources can be saved. We exhaustively evaluate and show the efficacy of BrewER on four real-world datasets.
[A case of pathological complete response to lt. Lateral lymph node metastasis from lower rectal cancer by S-1 combined neoadjuvant chemoradiotherapy]. (2014)

A 54-year-old man presented with an enlarged left (lt) lateral lymph node (LLN), which was detected by magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET-CT). Endoscopic examination of the colon revealed the presence of a type 1 tumor, 20mm in diameter, in the lower rectum; the tumor was diagnosed as a well-differentiated adenocarcinoma (tub1). The patient received combined neoadjuvant chemoradiotherapy (nCRT)with S- 1 for treatment of the rectal cancer and LLN metastasis (MP, T2N3M0, Stage IIIb). S-1 was administered orally at a dose of 120 mg/day on days 1-14, and 22-35; a total dose of 45 Gy was delivered (1.8 Gy/day, for 25 days). Upon nCRT, there was a remarkable reduction in the tumor size, the primary tumor receded, and the LLN decreased from 16 mm to 8 mm in diameter. The maximum standardized uptake value (SUVmax) also decreased from 3.8 to 1.9 on PET-CT. Six weeks after nCRT, ultralow anterior resection and bilateral lymph node dissections were performed. Histopathological examination showed a partial presence of cancer cells in the scarred primary tumor; however, no viable cancer cells were observed in the lt. LLN.