gebhart/patrepeval huggingface dataset:
Glycoprotein B Vaccine Is Capable of Boosting Both Antibody and CD4 T-Cell Responses to Cytomegalovirus in Chronically Infected Women (2011)

Traditionally, vaccines have been utilized to generate immune responses to a pathogen in a naive population. In the setting of congenital cytomegalovirus (CMV) infection, a vaccine that, when administered to women already infected with CMV, could boost the mother's immunity to CMV would most likely be beneficial in diminishing in utero transmission of CMV. However, the ability to boost an immune response in a population of individuals seropositive for a pathogen of interest is not well studied. This study examines the ability of a recombinant CMV glycoprotein B vaccine with MF59 adjuvant to boost both antibody (neutralizing and enzyme-linked immunosorbent assay end point dilution titer) and CD4+ T-cell responses in previously CMV-seropositive women by way of natural infection. These data suggest that this vaccine is capable of boosting immunity in a population of CMV-infected women and warrants additional evaluation to determine whether these boosted responses may prevent mother to child transmission of CMV.
Signal transduction and biochemical targeting of ovarian carcinoma. (2000)

The purpose was to identify novel targets for the chemotherapy of ovarian carcinoma.Assays were worked out to measure the activities of P1 kinase, PIP kinase and PLC in ovarian carcinoma samples and in OVCAR-5 cells and to compare the activities to those in normal ovaries. A method was also designed for measuring the concentration of the end product of signal transduction, IP3.Signal transduction activity was markedly increased in ovarian cancer cells as shown by the increased steady-state activities of the three enzymes and the elevated concentrations of IP3. Inhibitors blocked activities of PI kinase (quercetin), PIP kinase (genistein), and lowered GTP concentration required for PLC (tiazofurin). Combinations of tiazofurin with quercetin, tiazofurin with genistein, and quercetin with genistein yielded a synergistic kill of ovarian cancer cells. Tiazofurin, quercetin and genistein are in various stages of clinical trials.The increased signal transduction activity provides novel, sensitive targets to chemotherapy in ovarian cancer cells.
Effect of chronic alcohol ingestion on buccal mucosal expression of bFGF and Cdk2 during ulcer healing (1998)

In this study, we investigated the effect of chronic alcohol ingestion on the interplay between the receptor-bound basic fibroblast growth factor (bFGF-R) and the expression of cyclin-dependent kinase (Cdk2) in buccal mucosa during ulcer healing. Chronic ulceration was induced by a topical application of acetic acid to the buccal mucosa of rats maintained for 5 weeks on alcohol-containing or control liquid diet. In both groups, the ulcer healing was accompanied by an increase in buccal mucosal expression of bFGF and Cdk2. In the control group, the ulcer healed within 10 days and maximum induction in bFGF (2.6-fold) and Cdk2 (2.4-fold) occurred by the 2nd day of healing. In contrast, the alcohol diet group showed a marked delay in ulcer healing (14 days), associated with the shift in maximum of bFGF and Cdk2 expression to the 4-6th day, and the values were reduced by 35 to 38%. The findings show that chronic alcohol ingestion exerts detrimental effect on the signaling events initiated by bFGF-receptor activation and propagated by Cdk2 that propels the cell cycle progression essential for rapid mucosal repair.
ChemInform Abstract: Broad‐Spectrum Liquid‐ and Gas‐Phase Decontamination of Chemical Warfare Agents by One‐Dimensional Heteropolyniobates. (2016)

Abstract A wide range of chemical warfare agents and their simulants are catalytically decontaminated by K 12 [Ti 2 O 2 ] [GeNb 12 O 40 ]·19H 2 O under mild conditions and in the dark.
Active noise cancellation of motion artifacts in pulse oximetry using isobestic wavelength light source (2011)

The measurement of oxygen saturation using pulse oximeters requires clean photoplethysmograph (PPG) signals, as motion artifacts often lead to a significant degree of error in the computation. This paper proposes a method for reducing motion artifacts from corrupted PPG signals by applying a normalized least mean squares (NLMS) algorithm, using an isobestic point wavelength (800nm) as a noise reference signal for the adaptive filter. A finger ring type sensor was demonstrated to be more comfortable than a clip type sensor. Experimental results indicate that the proposed method is suitable for reconstructing PPG signals and improving the accuracy of measuring oxygen saturation in the blood.
The Differential Gas Turbine Using Electric Transmission (1994)

This paper describes studies of simple gas turbine engines integrated with electrical transmission components. Recent developments in high-speed lightweight electrical machines and compact power electronics have enabled alternators and motors to be produced which can be coupled directly to the shaft of a gas turbine without an intermediate gearbox. For applications which require a wide range of power outputs, a single-shaft gas turbine with a high speed alternator can be run at constant speed while varying the current drawn from the alternator. This combines the flexibility of operation of a separate power turbine with the simplicity of a single-shaft engine. With this arrangement, in traction use high torques are obtained at low speed, while near-constant engine efficiency is sustained to about 50% of the design power. In the differential engine, the mechanical linkage between the compressor and the turbine is replaced with an electrical linkage. The turbine drives an alternator, and part of the alternator power is taken by a high-speed motor to drive the compressor. The excess alternator power forms the output of the engine. The compressor and turbine are now able to run at different speeds, and their operating points can be separately optimised at different engine conditions. For such an engine, studies show that high efficiency can be maintained to low power levels.
Serum bioactive and immunoreactive luteinizing hormone in man, a multicentric study (1997)

Ce travail rapporte une etude multicentrique de la mesure de l'activite biologique de l'hormone luteotrope (hLH) basee sur l'evolution de la production de testosterone par des cellules de Leydig animales en presence de concentrations variables de hLH. Cinq laboratoires ont participe a cette etude. Les methodologies employees sont differentes, de meme que l'origine des cellules leydigiennes d'animaux (rat, souris, porc). Les reponses obtenues a la stimulation par la hLH, les criteres de qualite des methodes et les resultats sur une population d'hommes et de femmes sains sont rapportes et discutes. De telles methodes peuvent actuellement etre considerees comme les methodes de reference des dosages de hLH utilisables en cas de divergences entre la clinique et les resultats de methodes immunologiques.
Temperature coefficients of the rates of acid-catalyzed enolization of acetone and ketonization of its enol in aqueous and acetonitrile solutions. Comparison of thermodynamic parameters for the keto-enol equilibrium in solution with those in the gas phase (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemperature coefficients of the rates of acid-catalyzed enolization of acetone and ketonization of its enol in aqueous and acetonitrile solutions. Comparison of thermodynamic parameters for the keto-enol equilibrium in solution with those in the gas phaseY. Chiang, A. J. Kresge, and N. P. ScheppCite this: J. Am. Chem. Soc. 1989, 111, 11, 3977–3980Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://doi.org/10.1021/ja00193a033Request reuse permissionsArticle Views888Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (446 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effect of diet on pathogen performance in the microbiome (2022)

Intricate interactions among commensal bacteria, dietary substrates and immune responses are central to defining microbiome community composition, which plays a key role in preventing enteric pathogen infection, a dynamic phenomenon referred to as colonisation resistance. However, the impact of diet on sculpting microbiota membership, and ultimately colonisation resistance has been overlooked. Furthermore, pathogens have evolved strategies to evade colonisation resistance and outcompete commensal microbiota by using unique nutrient utilisation pathways, by exploiting microbial metabolites as nutrient sources or by environmental cues to induce virulence gene expression. In this review, we will discuss the interplay between diet, microbiota and their associated metabolites, and how these can contribute to or preclude pathogen survival.
Blinatumomab for the treatment of B-cell lymphoma (2015)

The recent approval of blinatumomab for B-ALL symbolizes a breakthrough for BiTE technology with prospective application in the targeted therapy of other cancers. Although blinatumomab seems an unlikely option for treating indolent lymphoma due to toxicity, the need for long-term continuous infusion therapy and multiple promising well-tolerated oral agents, it holds promise for aggressive NHL patients whose diseases are refractory to current standard approaches. Larger trials are needed to demonstrate blinatumomab's curative potential in aggressive histologies.
Effects of excess energy on supersaturated Fe–IIIB thin films with ion-plating process (2015)

In this study, Fe–IIIB thin films were prepared by dual vapour source ion-plating process and the effects of excess energy on their nanostructure and magnetostrictive characteristics were investigated. The samples of Fe–40 at.-%Al, Fe–17 at.-%Ga and Fe–1.5 at.-%In showed the maximum value of magnetostriction were about 150, 200 and 80 ppm at 1200 kA m−1, respectively. The excess energy incidences of ions onto depositing films surfaces are key parameters for magnetostrictive properties. The excess energy was increased by escalating the impinging energy of evaporation particles with rising anode probe voltage and substrate bias voltage. In the ion-plating process, the excess energy was more than a mixture enthalpy of Fe and IIIB. The accumulated lattice distortion energy was enlarged by increasing the lattice expansion of the α-Fe bcc lattice. The excess energy in the ion-plating process can control the solid solubility limit and crystallographic characterisation of films.
Patient-Reported Barriers to Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis (2016)

Patients on ART face multiple barriers to adherence, and no single intervention will be sufficient to ensure that high levels of adherence to treatment and virological suppression are sustained. For maximum efficacy, health providers should consider a more triaged approach that first identifies patients at risk of poor adherence and then seeks to establish the support that is needed to overcome the most important barriers to adherence.
Progress in up-scaling of thin film silicon solar cells by large-area PECVD KAI systems (2005)

UNAXIS KAI PECVD reactors developed for AM LCD technology have been demonstrated to possess a high potential for thin film silicon solar cells based on amorphous and microcrystalline silicon. For the next generation of thin film modules with highly effective light-trapping LP-CVD ZnO large-area deposition is developed at Unaxis as well, in combination with a very simple but effective back reflector concept. A first prototype module of 0.447 m/sup 2/ active area with 7.1% initial efficiency has been achieved for amorphous silicon. Micromorph mini-modules were prepared with 9.3% initial aperture efficiency. All important module fabrication steps are under development at Unaxis for a complete line concept.
Differing effects of the anxiolytic agents buspirone and diazepam on control of breathing (1991)

We compared ventilatory effects of the nonsedating anxiolytic buspirone with those of the sedating anxiolytic diazepam in nine normal men. Resting ventilatory parameters and ventilatory responses to CO2 rebreathing and inspiratory threshold loading were measured before and after placebo, diazepam, and buspirone. Placebo had no ventilatory effects. Diazepam had no effect on resting ventilation but depressed response to CO2. Buspirone had no effect on resting ventilation or CO2 response. During loading, buspirone did not alter the augmentation of mouth pressure; diazepam produced a trend toward less augmentation. Both anxiolytics altered the load compensation response for the group; in particular, an increase in ventilation during loading (seen in three of nine subjects) was suppressed by drug administration. Diazepam also markedly depressed one subject's loaded ventilation below unloaded ventilation. In summary, buspirone did not cause the depression of respiratory center chemosensitivity that was seen with diazepam and produced less depression of load compensation in normal subjects. This suggests that it may be a safer anxiolytic in patients with lung disease.
Vehicle Traffic as a Source for Near-Surface Passive Seismic Imaging (2009)

In this paper, we present preliminary results from a field experiment in which we explored the&lt;br&gt;use of cars and traffic as a source for passive seismic imaging. We set out a line of geophones at a 45&lt;br&gt;degree angle between two intersecting roads at the University of California, Richmond Field Station.&lt;br&gt;We collected data sets including background noise, an idling car at the intersection of the roads, one car&lt;br&gt;driving on one road and two cars driving on both roads.
A novel measurand independent of the distance between the source and detector for continuous wave near-infrared spectroscopy (2017)

A new measurand is proposed for use in continuous wave near-infrared spectroscopy (cw-NIRS). The conventional measurand of cw-NIRS is l△c, which is the product of the change in the hemoglobin concentration (△c) and the partial path lengh (l), which depends on the source-detector (SD) distance (d). The SD distance must remain constant during cw-NIRS measurements, and we cannot compare the l△c value with that obtained using a different SD distance. In addition, the conventional measurand obtained using the standard measurement style sometimes includes a contribution from the human scalp. The SD distance independent (SID) measurand obtained using multi-SD distances is proportional to the product of the change in hemoglobin concentration and the derivative of the partial path length for the deep region with no scalp contribution under the assumption of a layer model. The principle of SID was validated by the layered phantom study. In order to check the limitation of assumption, a human study was conducted. The value of the SID measurand for the left side of the forehead during working memory task was approximately independent of the SD distance between 16 and 32 mm. The SID measurand and the standardized optode arrangement using flexible SD distances in a head coordinate system must be helpful for comparing the data in a population study.
When to use a compilation service? (2002)

Modern handheld computers are certainly capable of running general purpose applications, such as Java virtual machines. However, short battery life rather than computational capability often limits the usefulness of handheld computers. This paper considers how to reduce the energy consumption of Java applications.Broadly speaking, there are three interleaved steps in running Java programs in a compiled environment: downloading the bytecodes, compiling and possibly optimizing the bytecodes, and running the compiled code. Optimized code typically runs faster than non-optimized code but the optimization process itself may consume significant energy. We consider the possibility of moving compilation (optimizing or non-optimizing) to a tethered server. We demonstrate that there is a significant benefit to moving compilation to a server (up to 67% reduction in energy for a realistic handheld configuration). We also demonstrate that there is no single best compilation strategy for all methods.
El bitcoin no es dinero. Comentario a la Sentencia del Tribunal Supremo de 20 de junio de 2019 (2019)

espanolCon su sentencia de 20 de junio de 2019, el TS elimina de un plumazo la posibilidad de que el bitcoin ostente naturaleza de dinero, ya que se trata de un bien inmaterial «de naturaleza digital» y porque necesita del acuerdo de dos partes para su aceptacion como medio de pago. EnglishWith its judgement 20 June 2019, the Spanish Supreme Court ruled out at a stroke the possibility that bitcoin might have the money, since it is an intangible good of a digital nature and because it requires the agreement two parties for its acceptance as a means payment.
Waveguide grating spectral phase-shifter for temporal femtosecond pulse splitting (2007)

A waveguide grating based on a mirror causes a 2pi phaseshift of controllable slope in the spectrum of a femtosecond pulse giving rise to an adjustable, lossless temporal pulse splitting. A representation of resonant reflection based on phenomenological parameters enables the designer to achieve the synthesis of the mirrored waveguide grating structure exhibiting the desired temporal pulse shape. The example of a temporal beam splitter under fabrication is presented. Experimental results will be presented at the conference.
Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily (2015)

Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most recent literature has highlighted the importance of multi target kinase inhibitors, although a correct balance between specificity and non-specificity is required. In this view, the discovery of multi-tyrosine kinase inhibitors with subfamily selectivity is a challenging goal. Herein we present the synthesis and the preliminary kinase profiling of a set of novel 4-anilinopyrimidines. Among the synthesized compounds, the N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives selectively targeted some members of class III receptor tyrosine kinase family. Starting from the structure of hit compound 19 we synthesized a further compound with an improved affinity toward the class III receptor tyrosine kinase members and endowed with a promising antitumor activity both in vitro and in vivo in a murine solid tumor model. Molecular modeling simulations were used in order to rationalize the behavior of the title compounds.
The first example of commensurate adsorption of atomic gas in a MOF and effective separation of xenon from other noble gases (2013)

In industry, cryogenic rectification for separating xenon from other noble gases such as krypton and argon is an energy and capital intensive process. Here we show that a microporous metal–organic framework, namely Co3(HCOO)6 is capable of effective capture and separation of xenon from other noble gases. Henry's constant, isosteric heat of adsorption (Qst), and IAST selectivity are calculated based on single component sorption isotherms. Having the highest Qst reported to date, Co3(HCOO)6 demonstrates high adsorption capacity for xenon and its IAST selectivity for Xe–Kr is the largest among all MOFs investigated to date. To mimic real world conditions, breakthrough experiments are conducted on Xe–Kr binary mixtures at room temperature and 1 atmosphere. The results are consistent with the calculated data. These findings show that Co3(HCOO)6 is a promising candidate for xenon capture and purification. Our gas adsorption measurements and molecular simulation study also reveal that the adsorption of xenon represents the first example of commensurate adsorption of atomic gases near ambient conditions.
The zebrafish issue ofDevelopment (2012)

In December 1996, a special issue of Development appeared that presented in 37 papers the results of two large screens for zebrafish mutants performed in Tübingen and Boston. The papers describe about 1500 mutations in more than 400 new genes involved in a wide range of processes that govern development and organogenesis. Up to this day, the mutants provide a rich resource for many laboratories, and the issue significantly augmented the importance of zebrafish as vertebrate model organism for the study of embryogenesis, neuronal networks, regeneration and disease. This essay relates a personal account of the history of this unique endeavor.
Microstructure and Impurities of Bronze Coin, Headongtongbo, Fabricated in the Korai Period (11th Century) (2010)

The microstructure of the bronze coin, Headongtongbo, circulated around 1097 and fabricated in the Korai period (10~14th centuries) has been investigated. The coin is 23.4 mm in diameter and 1.7 mm in thickness with weight of 4.75 g. Transmission electron microscope, X-ray diffraction, scanning electron microscope, and electron dispersive X-ray analyses are used to determine the structure of the specimen. The composition of the specimen is Cu-6.1 mass%Sn-1.4 mass%Pb-0.5 mass%S. αCu, Pb and Cu2S grains are observed using an optical microscope. The Cu2S phase has been observed in a Korai bronze mirror, as reported in the previous paper. The αCu phase shows a recrystallized polygonal structure. In some part of the αCu grains, twins and fine twinlike lines are observed. Cu2S particles are dispersed in αCu grains and the grain boundary. In αCu grains near the surface, grain boundaries and the twin boundary are corroded preferentially. The Cu2S grains retain their original shape and remain in the corroded layer. αCu corrodes from Cu2O to CuO, and then to Cu2CO3(OH)2.
ChemInform Abstract: SYNTHESES, CHEMICAL PROPERTIES, AND X‐RAY CRYSTAL STRUCTURES OF RHENIUM FORMALDEHYDE AND THIOFORMALDEHYDE COMPLEXES (1983)

Abstract Der n′ ‐Formaldehyd‐ und der n2 ‐Thioformaldehyd‐Re‐Komplex (II) werden durch Umsetzung des elektrophilen Methyliden‐Komplexes (I) mit dem Sauerstoff‐Nucleophilen Ph‐I+‐O′ oder mit Cyclohexensulfid gebildet.