gebhart/patrepeval huggingface dataset:
Validation of secreted protein OASEP1 as a prognostic biomarker and therapeutic target for oral cancer. (2020)

e18520 Background: Although current treatments for oral cancer (OC) include surgery, radiotherapy, and chemotherapy, their effectiveness is still limited. Therefore, the development of novel prognostic biomarkers and/or therapeutic agents is urgently needed. Methods: Our strategies are as follows: i) Identification of up-regulated genes in cancers by means of gene expression microarray, ii) Validation of clinicopathological significance of their protein expression by tissue microarray, iii) Examination of their growth effect on cancer cells by siRNAs and active ligand protein for growth assays. Results: We selected a secreted protein, OASEP1 (OC-associated serum protein 1) as a candidate. Real-Time qPCR and Western blotting showed that OASEP1 gene and its gene product were expressed in the majority of OC cells. Immunohistochemical staining showed that OASEP1 expression was observed in 73 (74.4%) of 98 OCs that had undergone curative surgery. In addition, high level of OASEP1 expression was associated with poor prognosis for OC patients ( P = 0.0158, by log-rank test). Suppression of OASEP1 expression by siRNAs for OASEP1 (si-OASEP1) significantly suppressed the growth and invasion of OC cell lines. Flowcytometry and live cell imaging showed that si-OASEP1 induced the apoptosis of OC cells. siRNAs against OASEP1-receptor also suppressed the growth of OC cells. Addition of active OASEP1 recombinant protein into culture media enhanced the growth of OC cells probably through AKT pathway. Our data suggest that OASEP1 and its receptor could play a significant role in the growth of OC cells in probable autocrine/paracrine manner. Conclusions: OASEP1 is a possible prognostic biomarker and therapeutic target for OC.
Treatment of Focal Status Epilepticus plus Epileptic Spasms with Leukotomy in an Infant with TSC 1 Mutation: A Case Study (2015)

We highlight the importance of epilepsy surgery in selected infants to achieve seizure freedom and to reverse epileptic encephalopathy. In the process, we demonstrate how epileptic spasms, although clinically and electrographically generalized, resolved after disconnecting the epileptogenic zone.
Measures of Appropriateness and Value for Breast Surgeons and Their Patients: The American Society of Breast Surgeons Choosing Wisely ® Initiative (2016)

The ASBrS list for the Choosing Wisely (®) campaign is easily accessible to breast cancer patients online. These measures provide surgeons and their patients with a starting point for shared decision making regarding potentially unnecessary testing and operations.
ChemInform Abstract: ETHYLENIMINE DERIVATIVES OF SOME 1,2,4‐TRIAZINES (1976)

Abstract Bei der Umsetzung der 3‐Methoxy‐1 ,2,4‐triazine (I) mit Äthylenimin entstehen Substitutionsprodukte wie (III), aus dem das Piperazin (IV) hergestellt werden kann.
Convolutional Neural Networks for Distant Speech Recognition (2014)

We investigate convolutional neural networks (CNNs) for large vocabulary distant speech recognition, trained using speech recorded from a single distant microphone (SDM) and multiple distant microphones (MDM). In the MDM case we explore a beamformed signal input representation compared with the direct use of multiple acoustic channels as a parallel input to the CNN. We have explored different weight sharing approaches, and propose a channel-wise convolution with two-way pooling. Our experiments, using the AMI meeting corpus, found that CNNs improve the word error rate (WER) by 6.5% relative compared to conventional deep neural network (DNN) models and 15.7% over a discriminatively trained Gaussian mixture model (GMM) baseline. For cross-channel CNN training, the WER improves by 3.5% relative over the comparable DNN structure. Compared with the best beamformed GMM system, cross-channel convolution reduces the WER by 9.7% relative, and matches the accuracy of a beamformed DNN.
Atmospheric pressure plasma diagnostics by OES, CRDS and TALIF (2010)

International audience
Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices (2014)

Haemorrhagic episodes in patients carrying circulatory assist devices represent a severe life-threatening clinical complication. These bleeding episodes may originate from a reduced functionality of von Willebrand factor (VWF), a multimeric protein pertinent to the formation of a haemostatic plug. It has been reported that the reduced functionality is due to increased proteolytic degradation by the enzyme ADAMTS13, a phenomenon that is facilitated by device-induced increases in shear stress to which VWF is exposed. Here, we have tested a series of VWF-derived protein fragments and monoclonal murine anti-VWF antibodies for their capacity to reduce shear stress-dependent degradation of VWF. Via direct binding experiments, we identified an anti-VWF antibody that partially blocked VWF-ADAMTS13 interactions (46 ± 14%). Epitope mapping experiments revealed that the antibody, designated mAb508, is directed against the distal portion of the VWF D4-domain (residues 2134-2301) and recognises a synthetic peptide encompassing residues 2158-2169. Consistent with its partial inhibition of VWF-ADAMTS13 interactions in binding assays, mAb508 reduced ADAMTS13-mediated VWF degradation in a vortex-based degradation assay by 48 ± 10%. In a HeartMateII-based whole blood-perfusion system, mAb508 was able to reduce degradation of high-molecular-weight (HMW)-VWF-multimers dose-dependently, with a maximal inhibition (83 ± 8%) being reached at concentrations of 10 μg/ml or higher. In conclusion, we report that partial inhibition of VWF-ADAMTS13 interactions using an anti-VWF antibody can prevent excessive degradation of HMW-VWF multimers. This strategy may be used for the development of therapeutic options to treat bleeding episodes due to shear stress-dependent VWF degradation, for instance in patients carrying circulatory assist devices.
Data from Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease. We hypothesized that ongoing steroidogenesis within prostate tumors and the maintenance of intratumoral androgens may contribute to castration-resistant growth. Using mass spectrometry and quantitative reverse transcription–PCR, we evaluated androgen levels and transcripts encoding steroidogenic enzymes in benign prostate tissue, untreated primary prostate cancer, metastases from patients with castration-resistant prostate cancer, and xenografts derived from castration-resistant metastases. Testosterone levels within metastases from anorchid men [0.74 ng/g; 95% confidence interval (95% CI), 0.59–0.89] were significantly higher than levels within primary prostate cancers from untreated eugonadal men (0.23 ng/g; 95% CI, 0.03–0.44; &lt;i&gt;P&lt;/i&gt; &lt; 0.0001). Compared with primary prostate tumors, castration-resistant metastases displayed alterations in genes encoding steroidogenic enzymes, including up-regulated expression of FASN, CYP17A1, HSD3B1, HSD17B3, CYP19A1, and UGT2B17 and down-regulated expression of SRD5A2 (&lt;i&gt;P&lt;/i&gt; &lt; 0.001 for all). Prostate cancer xenografts derived from castration-resistant tumors maintained similar intratumoral androgen levels when passaged in castrate compared with eugonadal animals. Metastatic prostate cancers from anorchid men express transcripts encoding androgen-synthesizing enzymes and maintain intratumoral androgens at concentrations capable of activating AR target genes and maintaining tumor cell survival. We conclude that intracrine steroidogenesis may permit tumors to circumvent low levels of circulating androgens. Maximal therapeutic efficacy in the treatment of castration-resistant prostate cancer will require novel agents capable of inhibiting intracrine steroidogenic pathways within the prostate tumor microenvironment. [Cancer Res 2008;68(11):4447–54]&lt;/p&gt;&lt;/div&gt;
VISIR-SAT – A PROSPECTIVE MICRO-SATELLITE BASED MULTI-SPECTRAL THERMAL MISSION FOR LAND APPLICATIONS (2015)

Abstract. Current space-borne thermal infrared satellite systems aimed at land surface remote sensing retain some significant deficiencies, in particular in terms of spatial resolution, spectral coverage, number of imaging bands and temperature-emissivity separation. The proposed VISible-to-thermal IR micro-SATellite (VISIR-SAT) mission addresses many of these limitations, providing multi-spectral imaging data with medium-to-high spatial resolution (80m GSD from 800 km altitude) in the thermal infrared (up to 6 TIR bands, between 8 and 11μm) and in the mid infrared (1 or 2 MIR bands, at 4μm). These MIR/TIR bands will be co-registered with simultaneously acquired high spatial resolution (less than 30 m GSP) visible and near infrared multi-spectral imaging data. To enhance the spatial resolution of the MIR/TIR multi-spectral imagery during daytime, data fusion methods will be applied, such as the Multi-sensor Multi-resolution Technique (MMT), already successfully tested over agricultural terrain. This image processing technique will make generation of Land Surface Temperature (LST) EO products with a spatial resolution of 30 x 30 m2 possible. For high temperature phenomena such as vegetation- and peat-fires, the Fire Disturbance Essential Climate Variables (ECV) “Active fire location” and “Fire Radiative Power” will be retrieved with less than 100 m spatial resolution. Together with the effective fire temperature and the spatial extent even for small fire events the innovative system characteristics of VISIR-SAT go beyond existing and planned IR missions. The comprehensive and physically high-accuracy products from VISIR-SAT (e.g. for fire monitoring) may synergistically complement the high temperature observations of Sentinel-3 SLSTR in a unique way. Additionally, VISIR-SAT offers a very agile sensor system, which will be able to conduct intelligent and flexible pointing of the sensor’s line-of-sight with the aim to provide global coverage of cloud free imagery every 5–10 days with only one satellite (using near real time cloud cover information). VISIRSAT may be flown in convoy with Sentinel-3 and/or Sentinel-2.
Modelling of Swimming Ability Limits for Marine Fish (1997)

The total energy of fish movement and the maximum burst swimming speed were estimated and formulated in accordance with body length and water temperature for several species in fisheries by empirical methods and also by using published results. Under the assumption of swimming energy reserve of a fish at the initial rest state, the swimming endurance of fish with different body lengths, swimming speeds and angular velocity was calculated using the relevant equations under similar conditions in tank experiments as well as natural conditions in field. Relative swimming energy efficiency or the transition swimming speed between red and white muscle for energy consumption was represented as a trigonometric function of swimming speed ratio. Therefore, this model does closely approach the actual swimming abilities and their limits especially in relation to the fishing gear operation and allow for the greater vitality of the wild fish in the fields.
Affective interactions between expressive characters (2005)

When people meet in virtual worlds they are represented by computer animated characters that lack a variety of expression and can seem stiff and robotic. By comparison human bodies are highly expressive; a casual observation of a group of people mil reveals a large diversity of behavior, different postures, gestures and complex patterns of eye gaze. In order to make computer mediated communication between people more like real face-to-face communication, it is necessary to add an affective dimension. This paper presents Demeanour, an affective semi-autonomous system for the generation of realistic body language in avatars. Users control their avatars that in turn interact autonomously with other avatars to produce expressive behaviour. This allows people to have affectively rich interactions via their avatars.
Bone Marrow Stroma-Derived Mesenchymal Cell Cultures from Nude/Nude Rat Showing Both Ex Vivo Differentiation Properties and High Metastatic Potential in Nude Mice. (2004)

Abstract Recent studies have revealed that stem cell like cancer cells can be isolated from different types of primary tumor tissue from brain, breast and skin. Such cells have high capability to form tumors when transplanted into experimental animals. Here we describe a newly developed nude rat mesenchymal stem cellS (rMSCs), which spontaneously changed in vivo properties during culturing. Rat bone marrow cells were isolated from the femur and tibia of a male nude/nude rat and cultured in DMEM medium supplemented with 20% bovine fetal serum (FCS). Non- adherent cells were removed after 72 hours of incubation and the adherent bone marrow cells were cultured until a confluent layer appeared. Adherent cells were detached by trypsin, washed and continued to be cultured. After 23 passages by high-density culture the rMSCs spontaneously became more homogenous and formed spheroids in three-dimensional culture. Following ex vivo culturing under different growth conditions these cells were still able to differentiate into fat and neural like cells. The rMSCs also contain high numbers of colony-forming-unit-fibroblasts(cfu-f). The “tumourigenic” growth pattern observed ex vivo prompted us to examine the rMSCs in vivo. Following subcutaneous injection of 1 x106 cells into nude/nude mice a solid tumor appeared under the skin after 12 days. Moreover, intravenous injections and direct injections into left heart ventricle of rMSCs created solid tumors both in the lung, abdominal cavity, bone and skin. Both phenotypic and genetic characterization of early and late passages of the rMSCs and the tumors formed in the mice are being investigated and more details will be presented at the meeting.
THERMAL CHARACTERISTICS OF A 150-kw ARC IMAGE SYSTEM (1963)

the forseeable future the cost of conventional energy were to inflate 8% faster than the cost of the commodities needed by the solar system. A 17% differential inflation rate would produce a 10% rate of return. Reduction in cost of the shallow solar ponds potentially could reduce the system installation cost by about 20%.
Abstract 20500: Trx1 Promotes Trans-Nitrosylation of Cellular Proteins to Stimulate Autophagy and Cell Survival (2014)

Thioredoxin-1 (Trx1) is cardioprotective during oxidative stress, mainly through its antioxidant activity. Trx1 is also S-nitrosylated and, in turn, trans-nitrosylates other proteins. However, the role of Trx1-dependent S-nitrosylation in cardiomyocytes (CMs) is unknown. Here, we investigated the role of Trx1-mediated protein S-nitrosylation in the regulation of CM survival during stress in vitro. Using biotin-switch assays, we found that wild-type Trx1 (Trx1WT) is S-nitrosylated at baseline, but the extent of S-nitrosylation was attenuated in Trx1C73S, suggesting that Trx1 is S-nitrosylated at Cys73. Trx1WT and Trx1C73S do not differ in their redox activity, as determined by Amplex Red assays. Cellular protein S-nitrosylation levels were increased after 4 hours of glucose deprivation (GD), an energy stress condition (1.64±0.27 fold, p&lt;0.05), as determined by biotin switch assays. Overexpression of Trx1WT increased (3.94-fold), whereas knockdown of Trx1 (0.66±0.01 fold, p&lt;0.01) or overexpression of Trx1C73S (0.77±0.02 fold, p&lt;0.01) decreased, total protein S-nitrosylation in response to GD. These results suggest that Trx1C73 regulates protein S-nitrosylation in CMs during GD. Overexpression of Trx1 increased CM survival after 24 hours of GD (1.42±0.08 fold vs LacZ, p&lt;0.05), as evaluated with propidium iodide assays. Conversely, shTrx1 (2.13±0.05 fold vs control, p&lt;0.01) or Trx1C73S (1.73±0.034 fold vs LacZ, p&lt;0.01) increased cell death during GD. Either knockdown of Trx1 (LC3-II/Tubulin: 0.55 fold vs control) or overexpression of Trx1C73S (vs LacZ: LC3-II/Tubulin, 0.60 fold; autophagosomes, 0.83±0.16-fold, p&lt;0.005; autolysosomes, 0.62±0.13-fold, p&lt;0.005) significantly decreased autophagy during GD. Mechanistically, Trx1 co-immunoprecipitates with Atg7, an E1-like protein which plays a critical role in mediating autophagy. Using mass spectroscopy analyses, we found that SNO-Trx1 can trans-nitrosylate Atg7 in vitro. These results suggest that Trx1 trans-nitrosylates Atg7 during GD. Taken all together, our results indicate that Trx1 promotes trans-nitrosylation of cellular proteins, including Atg7, and autophagy, thereby promoting cell survival during energy stress in CMs.
Advanced laminate carrier module warpage considerations for 32nm pb-free, FC PBGA package design and assembly (2011)

The trend in large body, high performance integrated circuit packaging for the 32 nm semiconductor node and beyond is towards low dielectric loss to enable high bandwidth / low loss channels, and low thermal expansion to protect fragile, ultra-low dielectric constant (k) chip dielectric materials from differential expansion stress. A low coefficient of thermal expansion (CTE), low dielectric loss laminate composite was developed using industry standard Sequential Build Up (SBU) fabrication techniques and novel laminate materials. This laminate technology was used in assembly of a Flip Chip Plastic Ball Grid Array (FC PBGA) module including a silicon test structure developed for 32 nm Custom Logic development. The same silicon test structure and laminate design were also used to fabricate modules using conventional high volume laminate materials. Various laminate physical parameters including composite CTE were determined. The warpage shape of each laminate was initially characterized at room temperature, and over the temperature range from 25°C to 240°C. Warpage of critical package features was measured and tracked throughout the various steps of the lead free flip chip module assembly process for multiple laminate cross sections, core and buildup materials. A quantity of assemblies of each type was built and measured, data is reported. Advantages and disadvantages of each laminate module type and implications for robust package assembly as evidenced by these results are discussed.
On the use of averaging for the analysis of power electronic systems (1990)

Averaging theory as a rigorous framework for evaluating, refining, and extending heuristic averaged models now used in power electronics is introduced. It is shown that averaging theory provides direct techniques for recovering oscillatory effects such as ripple from the averaged model. As an application of the theory, examples of the analysis of simple DC-DC converters are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Six‐Nitrogen Macrocyclic Complexes of the Dioxouranium(VI) and Praseodymium(III) Ions. (1989)

Abstract The Schiff‐base condensation of diacetylpyridine (I) and diaminobenzene (III) in the presence of the uranyl salts (II) produces the complexes (IV).
Effect of Caffeinated Gum on Choice Reaction Time (2019)

Caffeine ingestion is a common practice for individuals seeking to feel more awake or trying to improve performance. Rather than consuming caffeinated drinks, a more recent trend is that of chewing caffeinated gum. Published research in this area, particularly in support of benefits to fine motor performance, is limited. PURPOSE: To determine if chewing Military Energy Gum (MEG, MarketRight Inc, Plano, IL) compared to a placebo can improve choice reaction time (CRT, MOART System, Lafayette, IN) under rested and fatigued conditions. METHODS: Twenty-two (12 males, 10 females), college-aged (mean + SD: 21 + 1.1 yrs; 1.73 + 0.10 m in ht; 74.6 + 14.18 kg in wt), volunteers participated in a double-blind, cross-over, placebo-based study. All subjects completed an IRB consent form. Subjects were asked to be available for testing on two non-consecutive days, for one hour. Prior to each testing period, subjects fasted from food for 7 hours and abstained from alcohol for 24 hours. Upon arrival the first day, subjects completed a brief health assessment survey, performed the CRT and the Wingate cycling power (WCP) test. Subjects performed the CRT (pre-gum CRT), were given two pieces of either 200 mg caffeinated MEG (cMEG) or placebo MEG (pMEG), chewed the gum for ten minutes, and again performed the CRT (post-gum CRT), completed the WCP test, and did CRT for third time (post-gum WCP). A mixed-methods ANOVA was conducted to determine if a group (MEG, placebo) by time (pre-gum, post-gum, post-WCP) interaction on choice reaction time existed. Significance was established at p < 0.05. RESULTS: There was no statistically significant interaction between group and time. However, CRT for the cMEG improved significantly from pre-gum (0.544 + .09 sec) to post-gum (0.504 + .07 sec), and pre-gum to post-Wingate (M = .483 + .08 sec). CONCLUSION: When compared to a placebo, caffeinated MEG did not significantly improve choice reaction time of college-aged participants under rested or fatigued conditions. Yet, choice reaction timing did show an improving trend during the sequential testing.
Science and policy on endocrine disrupters must not be mixed: a reply to a “common sense” intervention by toxicology journal editors (2013)

The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
High-Accuracy Wide-Range Measurement Method for Determination of Complex Permittivity in Reentrant Cavity: Part A --- Theoretical Analysis of the Method (1980)

New mathematical method for calculation of complex electric permittivity (epsilon) of a wide range of materials from the direct measured parameters of a reentrant cavity containing a sample of material is presented. Condition of resonance is drawn based on analysis of electromagnetic field distribution in the cavity with a sample. Accuracy of the obtained algorithm (convergences of series) and method of shortening iterative solution is discussed in detail.
A group recommendation approach for service selection (2012)

There are more and more services that fulfill similar functionality, such as image service provided by Flickr, Picasa and Facebook. Which should be adopted to construct our software system in the open, dynamic and non-deterministic Internet environment is a key problem. Earlier work[15, 9] analyze this problem from the point view of QoS and established generic and extensible QoS computation framework for service selection. However those framework are almost designed for individuals. As social network emerges and gets widespread, people tend to be more connected and self-organize themselves into groups. Benefits of all members should be considered when we select service for group. In this article, we propose a revised group recommendation algorithm which takes advantage of collaborative filtering technology for service selection. As the experiment demonstrates, our algorithm exhibits high accuracy.