gebhart/patrepeval huggingface dataset:
Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle. (1994)

We have investigated the role of wave-front curvature on propagation by following the wave front that was diffracted through a narrow isthmus created in a two-dimensional ionic model (Luo-Rudy) of ventricular muscle and in a thin (0.5-mm) sheet of sheep ventricular epicardial muscle. The electrical activity in the experimental preparations was imaged by using a high-resolution video camera that monitored the changes in fluorescence of the potentiometric dye di-4-ANEPPS on the surface of the tissue. Isthmuses were created both parallel and perpendicular to the fiber orientation. In both numerical and biological experiments, when a planar wave front reached the isthmus, it was diffracted to an elliptical wave front whose pronounced curvature was very similar to that of a wave front initiated by point stimulation. In addition, the velocity of propagation was reduced in relation to that of the original planar wave. Furthermore, as shown by the numerical results, wave-front curvature changed as a function of the distance from the isthmus. Such changes in local curvature were accompanied by corresponding changes in velocity of propagation. In the model, the critical isthmus width was 200 microns for longitudinal propagation and 600 microns for transverse propagation of a single planar wave initiated proximal to the isthmus. In the experiments, propagation depended on the width of the isthmus for a fixed stimulation frequency. Propagation through an isthmus of fixed width was rate dependent both along and across fibers. Thus, the critical isthmus width for propagation was estimated in both directions for different frequencies of stimulation. In the longitudinal direction, for cycle lengths between 200 and 500 milliseconds, the critical width was < 1 mm; for 150 milliseconds, it was estimated to be between 1.3 and 2 mm; and for the maximum frequency of stimulation (117 +/- 15 milliseconds), it was > 2.5 mm. In the transverse direction, critical width was between 1.78 and 2.32 mm for a basic cycle length of 200 milliseconds. It increased to values between 2.46 and 3.53 mm for a basic cycle length of 150 milliseconds. The overall results demonstrate that the curvature of the wave front plays an important role in propagation in two-dimensional cardiac muscle and that changes in curvature may cause slow conduction or block.
High temperature oxidation of high purity nickel: oxide scale morphology and growth kinetics (2003)

AbstractAbstractThe oxidation of high purity nickel was studied between 600 and 1200°C for scale thickness between 1 and 30 µm. At or above 1100° C, the scale growth kinetics are strictly parabolic. The scales are then compact with columnar and facetted NiO grains. A more complex behaviour is observed below 1000°C: (i) for test temperatures between 1000 and 800°C, mass gain curves cannot be fitted to a parabola, (ii) different scale morphologies and microstructures are observed depending on scale thickness and temperature, (iii) a duplex scale is formed below 800°C. In addition to the possible effect of grain-boundary diffusion, the departure of growth kinetics from simple pure parabolic kinetics could be also related to the complex scale microstructure and its large evolution during scale growth. In situ oxidation of nickel specimens in an environmental SEM equipped with a hot stage specimen holder permitted to follow the morphological evolution of NiO scales. In situ grown NiO scales show the same microstructural features as observed on Ni specimens oxidised for longer duration in pure oxygen at atmospheric pressure.Keywords: high purity nickeloxide scale
Using cloud services and machine learning to improve customer support : Study the applicability of the method on voice data (2018)

This project investigated how machine learning could be used to classify voice calls in a customer support setting. A set of a few hundred labeled voice calls were recorded and used as data. The calls were transcribed to text using a speech-to-text cloud service. This text was then normalized and used to train models able to predict new voice calls. Different algorithms were used to build the models, including support vector machines and neural networks. The optimal model, found by extensive parameter search, was found to be a support vector machine. Using this optimal model a program that can classify live voice calls was made.
Study on the Properties of Cellulose Acetate Composite Synergistically Toughened by Glycerol Triacetate and Modified Nano Titania (2023)

Abstract Glyceryl triacetate (GT) and nano titanium dioxide (TiO 2 ) filler modified by titanate coupling agent were used to toughen cellulose diacetate to prepare CA/GT/nano TiO 2 @NZD-201 composites. The effects of glyceryl triacetate and modified titanium dioxide filler on the mechanical properties and rheological properties of cellulose acetate were studied. The rheological properties showed that glyceryl triacetate and modified nano TiO2 significantly increased the plasticity of the composite, reduced the complex viscosity, reduced the rigidity, and increased the viscoelastic ratio. The impact resistance of the composite was improved by 101% due to the addition of modified nano titanium dioxide.
Mitochondrial disfunction as a cause of ALS. (2011)

Recent studies on patient with sporadic ALS and on in vitro and in vivo models of mendelian diseases have been addressed toward the unravelling of the mitochondrial behaviour in ALS, whether as a primarily pathogenic factor, or as a fundamental contributor to the cell death. Morphological evidence suggests mitochondria pathology in ALS and many physiological mechanisms involving these organelles appear deranged in ALS, such as energy production, apoptotic triggering, calcium homeostasis and axonal transport of mitochondria. The article briefly addresses recent advances on this field.
Coarse-to-Fine Image Search Using Neural Networks (1994)

The efficiency of image search can be greatly improved by using a coarse-to-fine search strategy with a multi-resolution image representation. However, if the resolution is so low that the objects have few distinguishing features, search becomes difficult. We show that the performance of search at such low resolutions can be improved by using context information, i.e., objects visible at low-resolution which are not the objects of interest but are associated with them. The networks can be given explicit context information as inputs, or they can learn to detect the context objects, in which case the user does not have to be aware of their existence. We also use Integrated Feature Pyramids, which represent high-frequency information at low resolutions. The use of multiresolution search techniques allows us to combine information about the appearance of the objects on many scales in an efficient way. A natural form of exemplar selection also arises from these techniques. We illustrate these ideas by training hierarchical systems of neural networks to find clusters of buildings in aerial photographs of farmland.
A new dead-weight testing machine of 100,000 pounds capacity (1930)

The functions of the Bureau of Standards are outlined, and the importance of calibrating testing machines is emphasized.
Cognitive radio MAC protocol for WLAN (2008)

To solve the performance degradation issue in current WLAN caused by the crowded unlicensed spectrum, we propose a cognitive radio (CR) media access protocol, C-CSMA/CA. The basic idea is that with cognitive radio techniques the WLAN devices can not only access the legacy WLAN unlicensed spectrum but opportunistically access any other under-utilized licensed spectrum without a license. The application scenario of C-CSMA/CA is infrastructure BSS (Basic Service Set) WLAN. C-CSMA/CA efficiently exploits the inherent characteristics of CSMA/CA to design distributed cooperative outband sensing to explore spectrum hole; moreover, it designs dual inband sensing scheme to detect primary user appearance. Additionally, C-CSMA/CA has the advantage to effectively solve the cognitive radio self-coexistence issues in the overlapping CR BSSs scenario. It also realizes station-based dynamic resource selection and utilization. It is compatible with any legacy WLAN (BSS) system. We develop and implement the simulation of C-CSMA/CA by OPNET. The simulation results show that C-CSMA/CA highly enhances throughput and reduces the queuing delay and media access delay.
3D inspection of electronic devices by means of stereo method on single camera environment (2008)

It is very important to guarantee the quality of the industrial products by means of visual inspection. In order to reduce the soldering defect with terminal deformation and terminal burr in the manufacturing process, this paper proposes a 3D visual inspection system based on a stereo vision with single camera. It is technically noted that the base line of this single camera stereo was precisely calibrated by the image processing procedure. Also to extract the measuring point coordinates for computing disparity; the error is reduced with original algorithm. Comparing its performance with that of human inspection using industrial microscope, the proposed 3D inspection could be an alternative in precision and in processing cost. Since the practical specification in 3D precision is less than 1 pixel and the experimental performance was around the same, it was demonstrated by the proposed system that the soldering defect with terminal deformation and terminal burr in inspection, especially in 3D inspection, was decreased. In order to realize the inline inspection, this paper will suggest how the human inspection of the products could be modeled and be implemented by the computer system especially in manufacturing process.
Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan — United States, 2016–2018 (2019)

In February 2018, a typhoid fever outbreak caused by Salmonella enterica serotype Typhi (Typhi), resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins, was reported in Pakistan. During November 2016-September 2017, 339 cases of this extensively drug-resistant (XDR) Typhi strain were reported in Pakistan, mostly in Karachi and Hyderabad; one travel-associated case was also reported from the United Kingdom (1). More cases have been detected in Karachi and Hyderabad as surveillance efforts have been strengthened, with recent reports increasing the number of cases to 5,372 (2). In the United States, in response to the reports from Pakistan, enhanced surveillance identified 29 patients with typhoid fever who had traveled to or from Pakistan during 2016-2018, including five with XDR Typhi. Travelers to areas with endemic disease, such as South Asia, should be vaccinated against typhoid fever before traveling and follow safe food and water practices. Clinicians should be aware that most typhoid fever infections in the United States are fluoroquinolone nonsusceptible and that the XDR Typhi outbreak strain associated with travel to Pakistan is only susceptible to azithromycin and carbapenems.
SU-FF-T-314: Initial Monte Carlo Analysis of the Dosimetric Effects of Gold Nanoparticle Radiosensitizers (2005)

Purpose: Monte Carlo simulations have been undertaken to quantify the dosimetry of tumors that have absorbed nanoparticle gold as radiosensitizers and irradiated with various radiotherapy modalities. Method and Materials: EGSnrcMP and BEAMnrcMP, well known and documented Monte Carlo Photon Transport simulation codes are used for therapy simulations. Previous measurements of uptake ratio's provide a basis for generating new radiation interaction cross sections for use in radiation transport simulations. Cross sections generated by the simulation software are checked against cross sections generated using the NIST (National Institute of Standards and Technology) Standard Reference Database 8 (XGAM) and found to agree to within about 0.5%. 250 kVp, and 6 MV and Ir-192 HDR spectra provided with the EGS package where used as sources. Tumors containing 0.5% to 5% Au by weight (the balance made up by water) and sized from 0.5 to 3 cm were simulated at various depths and compared to pure water. The effects of normal tissue absorption of gold in media surrounding the tumor were also investigated. Results: As expected, 250 kVp orthovoltage units showed the largest benefit from nanoparticles. A 50% absorption increase in tumors absorbing 1.5% Au by weight. Ir-192 therapy beams available from High Dose Rate Brachytherapy units treating 1.5% and 5% nanoparticle gold by weight showed a 13% and 38% increase in dose absorption rate for tumors 1cm from the source. 6MV photon beams treating a 3cm tumor at 10cm depth showed a modest 5% improvement. Surrounding media absorption of gold nanoparticles shifts both target and surrounding tissue absorption rates higher, but does not significantly change their relative absorption rates. Conclusion: These simulations suggest gold nanoparticles in some modalities are worth investigating as radiosensitizers. Initial research should focus on HDR modalities first.
A Traceability Service to Facilitate RFID Adoption in the Retail Supply Chain (2009)

Abstract. Nowadays, companies are suffering changes in the way they deal with their inventories and their whole supply chain management. New technologies are emerging to help them adapt to the changes and keep a competitive status, but the adoption of such technologies is not always easy. Even though a lot of research has been done for RFID, there are still some areas that are being left aside, like the traceability aspect, which is one of the most important concerns in the retail supply chain. We propose a service named TRASER (TRAceability SErvice for the Retail supply chain) that will help the companies adopt the new technologies into their existing environments, dealing with persistence and traceability, and allowing the users to manage their operation according to their business rules, workflows and historical data. 1
Energy Efficient Proactive Routing Scheme for Enabling Reliable Communication in Underwater Internet of Things (2021)

The Underwater Internet of Things (UIoT) is a network of smart interconnected devices operating under various aqueous environments. In UIoT, due to aqueous feature of signal absorption, data signals are transmitted at low frequency. Similarly, significant interference and collisions degrade transmission quality, resulting in a low Packet Delivery Ratio (PDR) and a long End-to-End (E2E) delay. Moreover, a significant amount of energy is being wasted due to the void hole problem, which arises when the source node does not identify an instant forwarder node. Thus, a reliable communication with enhanced network lifetime is highly desired in UIoT. Therefore, this work proposes a proactive energy Efficient Layer-by-Layer Watchman-based Collision Free Routing (ELW-CFR) scheme to address the above mentioned issues. The proposed scheme provides the low E2E delay and high PDR while avoiding the void hole problem. Extensive simulations have been performed to show the performance superiority of the proposed scheme against the state-of-the-art schemes.
Cellular and molecular mechanisms underlying presynapse formation (2013)

Synapse formation is a highly regulated process that requires the coordination of many cell biological events. Decades of research have identified a long list of molecular components involved in assembling a functioning synapse. Yet how the various steps, from transporting synaptic components to adhering synaptic partners and assembling the synaptic structure, are regulated and precisely executed during development and maintenance is still unclear. With the improvement of imaging and molecular tools, recent work in vertebrate and invertebrate systems has provided important insight into various aspects of presynaptic development, maintenance, and trans-synaptic signals, thereby increasing our understanding of how extrinsic organizers and intracellular mechanisms contribute to presynapse formation.
Managing for Enterprise Security (2004)

Security has become one of the most urgent issues for many organizations. It is an essential requirement for doing business in a globally networked economy and for achieving organizational goals and mission. But it is no small task. The technical and environmental complexity of today's organizations and the ever-increasing dependence on technology to drive and automate processes and create competitive advantages make security a challenging activity. Adding to this complexity is a growing list of vulnerabilities and increasingly sophisticated threats to which organizations are subjected on a daily basis. Organizations can no longer be effective in managing security from the technical sidelines. Security lives in an organizational and operational context, and thus cannot be managed effectively as a stand-alone discipline. Because security is a business problem, the organization must activate, coordinate, deploy, and direct many of its existing core competencies to work together to provide effective solutions. And to sustain success, security at an enterprise level requires that the organization move toward a security management process that is strategic, systematic, and repeatable—in other words, efficient at using security resources and effective at meeting security goals on a consistent basis. Managing for enterprise security defines a disciplined and structured means for realizing these objectives. This report presents the interim results of work done by members of the Networked Systems Survivability Program at the Software Engineering Institute in exploring these issues. The authors offer a view of the changing environment in which security must be performed and, from their field work and research, itemize characteristics of common existing approaches to security that limit effectiveness and success. A "desired state" as a security target for the organization is outlined, and the organizational transformation that the authors believe is essential for approaching security as a business problem is presented. Finally, the authors describe their current work in exploring solutions that they believe will enable this transformation.
Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin−Rapamycin Conjugates (2009)

Hyperactivation of the PI3K/AKT/mTOR signaling pathway is common in cancer, and PI3K and mTOR act synergistically in promoting tumor growth, survival, and resistance to chemotherapy. Thus, combined targeting of PI3K and mTOR presents an opportunity for robust and synergistic anticancer efficacy. 17-Hydroxywortmannin (2a) analogues conjugated to rapamycin (3a) analogues via a prodrug linker are uniquely positioned for this approach. Our efforts led to the discovery of diester-linked conjugates that, upon in vivo hydrolysis, released two highly potent inhibitors. Conjugate 7c provided enhanced solubility relative to 3a and to an equivalent mixture of 3a and 9a and demonstrated profound activity in U87MG mouse xenografts, achieving an MED of 1.5 mg/kg, following weekly intravenous dosing. At 15 mg/kg, 7c completely inhibited the growth of HT29 tumors, whereas an equivalent mixture of the inhibitors was poorly tolerated. In the A498 renal tumor model, 7c exhibited superior efficacy over 3a or 9a when administered as a single agent or in combination with bevacizumab. Thus, we have uncovered a novel approach to target both PI3K and mTOR via hybrid inhibitors, leading to a broader and more robust anticancer efficacy.
Broadband Photonic Radar Enabling Millimeter Resolution for Vital Sign Detection (2023)

We demonstrate the first photonics-assisted vital sign radar for detecting the respiration of a cane toad as a human proxy. This work paves the way for photonics-enabled, high-performance, contactless vital sign detection and monitoring.
Structural studies on aqueous and hydroalcoholic solutions of a polyene antibiotic: Amphotericin B (1977)

Abstract Circular dichroism and absorption and light scattering have been used to study the effect of ethyl alcohol on an aqueous solution of Amphotericin B (“Fungizone”), which is an antifungal heptene. In aqueous solution, light‐scattering studies show that Amphotericin B exists in an aggregated form. The estimated mass of these aggregates is about 2 × 10 6 daltons, representing about 2000 molecules. Since the aggregated form is high molecular weight and scattering, the CD involves probably the differential scattering of right and left polarized light. In aqueous solution, Amphotericin B exhibits a strong dissymetric couplet in CD at the wavelength of the absorption maximum (328 nm). This latter maximum presents a blue shift when compared with the normal absorption in polar organic solvents. In hydroalcoholic solutions, for alcohol concentrations below 35%, the molecular weight of the aggregates is unchanged, while the absorption and CD spectra are modified. For alcohol concentrations greater than 35%, the aggregates mass decreases quickly and becomes undetectable at 50% ethyl alcohol concentration. For these solutions, the CD and absorption spectra are practically constant and characteristic of unaggregated Amphotericin B form.
ARFBF model for non stationary random fields and application in HRTEM images (2015)

This paper presents a new model called Autoregressive Fractional Brownian Field (ARFBF) for analyzing textures which contain stationary and non-stationary components. The paper also proposes two estimation methods for the parameter of an isotropic fractional Brownian field based on Wavelet Packet (WP) spectrum: the Log-Regression on Diagonal WP spectrum (Log-RDWP) and the Log-Regression on Polar representation of WP spectrum (Log-RPWP). The Log-RPWP method provides a better estimation performance for small size images. We show the interest of ARFBF model and Log-RPWP for characterizing High-Resolution Transmission Electron Microscopy (HRTEM) images.
Mode-assisted Silicon Integrated Interferometric Optical Gyroscope (2019)

The increasing demands in consumer electronics markets have promoted the development of chip-scale optical gyroscopes. In this study, a mode-assisted on-chip silicon-on-insulator interferometric optical gyroscope is proposed and assessed. The proposed gyroscope uses two different spatial modes propagating oppositely in the sensing waveguide coil to form a fixed phase difference that ensures the system operating at the best sensitive point. Compared with conventional schemes, it avoids the phase modulator and the circulator, which are not easy to be integrated in the same platform. The simulated results show that the detectable angular rate reaches 0.64 deg/s with a footprint of 3.85 × 10<sup>-3</sup> m<sup>2</sup>. The experimental results validate the realization of the highly sensitive phase bias of the fabricated device.
The Reaction of Cyclic Carbinol Amides with Triflic Anhydride as a Method to Prepare α-Trifluoromethyl-Sulfonamido Furans (2003)

[reaction: see text] A novel synthesis of alpha-trifluoromethyl-sulfonamido furans via the reaction of cyclic carbinol amides with triflic anhydride has been developed. The reaction proceeds under very mild conditions with a wide set of representative lactams to provide the alpha-trifluoromethyl-sulfonamido-substituted furan in high yield. Rapid access to a 5-substituted indoline can be achieved by thermolysis of the N-but-3-enyl-substituted sulfonamido furan.