gebhart/patrepeval huggingface dataset:
Photochemical rearrangements of cross-conjugated cyclohexadienones related to epimaalienone (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical rearrangements of cross-conjugated cyclohexadienones related to epimaalienoneDrury Caine, Howard Deutsch, and John T. Gupton IIICite this: J. Org. Chem. 1978, 43, 2, 343–346Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/jo00396a039https://doi.org/10.1021/jo00396a039research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quenching of I*(5 2P1/2) by DF (1984)

The method of time-resolved, infrared fluorescence was used to determine the total rate constant for deactivating I* by DF, HF, and HCl. The rate constants are &amp;lt;1.05×10−4, 8.9×10−13, and 3.2×10−15 in units of cm3 molecule−1 s−1, respectively. Moreover, no evidence was found for collisionally enhancing the radiative rate of I* with partial pressures of up to 50 Torr of DF or 100 Torr of HCl.
High-DR High-Resolution Gamma-Ray Spectroscopy with 3" LaBr3 and SiPMs (2021)

We present a high-dynamic-range, high-resolution, gamma-ray spectrometer based on a 3" co-doped lanthanum bromide (LaBr <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> (Ce+Sr)) crystal (73 ph/keV conversion efficiency, 25 ns decay time) coupled to 144 Silicon Photomultipliers (SiPMs) from Fondazione Bruno Kessler. The system reaches 2.6% energy resolution at 662 keV ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs emission peak) and 100 keV - 30 MeV energy dynamic range thanks to a custom ASIC with automatic gain adaptation. Experimental measurements shown highlight the benefits of the gain-switching approach compared to a fixed gain, the performance at high count-rate, and the effectiveness of the custom temperature compensation platform for the SiPMs.
Additive‐Free Formic Acid Dehydrogenation Using a Pincer‐Supported Iron Catalyst (2020)

Abstract The iron complex ( iPr PN Me P)Fe(H) 2 (CO) ( iPr PN Me P=CH 3 N(CH 2 CH 2 P i Pr 2 ) 2 ), which features a pincer ligand with a tertiary amine, can give up to 100,000 turnovers for additive‐free formic acid dehydrogenation (FADH). This is two orders of magnitude higher than any previously reported base metal system. Mechanistic studies reveal the catalytic reaction pathway and provide guidance for the development of improved catalytic systems for additive‐free FADH.
III-nitride terahertz photodetectors for the Reststrahlen gap of intersubband optoelectronics (2017)

We report the development of terahertz intersubband photodetectors based on GaN/AlGaN quantum wells, covering the frequency range that is fundamentally inaccessible to existing III-V semiconductor devices due to Reststrahlen absorption. Two different approaches have been employed to mitigate the deleterious effects of the intrinsic polarization fields of nitride heterostructures: the use of suitably designed double-step quantum wells, and epitaxial growth on semipolar GaN substrates. Promising results are obtained with both approaches, which could be extended to other device applications as a way to utilize the intrinsic advantages of nitride semiconductors for THz intersubband optoelectronics.
The Pitfalls of Hashing for Privacy (2017)

Boosted by recent legislations, data anonymization is fast becoming a norm. However, as of yet no generic solution has been found to safely release data. As a consequence, data custodians often resort to ad-hoc means to anonymize datasets. Both past and current practices indicate that hashing is often believed to be an effective way to anonymize data. Unfortunately, in practice it is only rarely effective. This paper is a tutorial to explain the limits of cryptographic hash functions as an anonymization technique. Anonymity set is the best privacy model that can be achieved by hash functions. However, this model has several shortcomings. We provide three case studies to illustrate how hashing only yields a weakly anonymized data. The case studies include MAC and email address anonymization as well as the analysis of Google safe browsing.
Soft Thermoplastic Elastomer for Easy and Rapid Spin‐Coating Fabrication of Microfluidic Devices with High Hydrophilization and Bonding Performances (2018)

Abstract Spin‐coating process of a commercially available soft thermoplastic elastomer (sTPE) is demonstrated for the realization of microfluidic prototypes. It is a reliable, wrinkling‐free, and high‐yield holding and transfer methodology for single and multilayered devices fabrication. Complex microfluidic systems including embedded microlenses array, dilutor‐like chip for stable capillary filling, and pneumatically drive valve confirms the performances and quality of the process. The dissolved sTPE, a soft styrenic‐block polymer‐based material, is flexible in its raw state as poly(dimethylsiloxane) and thermoformable as classical thermoplastics. Depending on the solvent evaporation rate, two stable morphologies of the block nanodomains are revealed: either a nanocylinder or hexagonal nanospheres pattern. Both are evenly distributed over the whole surface and account for a uniform and convenient surface at a “microfluidic scale device.” Plasma hydrophilization allows a stable and hydrophilic surface (≈20° after 7 d). The biocompatibility is assessed through the cell culture proliferation assay of progenitor endothelial cells. This sTPE solution displays fast and reliable fabrication and assembly performances, it can achieve strong and stable hydrophilicity within a low level of initial equipment investment.
Angiotensin II–Converting Enzyme Inhibition Improves Survival, Ventricular Remodeling, and Myocardial Energetics in Experimental Aortic Regurgitation (2013)

In a controlled animal model of pure severe aortic valve regurgitation, Cpt treatment reduced LV remodeling and LV hypertrophy and improved myocardial metabolic profile and survival. These results support the need to reevaluate the role of angiotensin-converting enzyme inhibitors in humans with AR in a large, carefully designed prospective clinical trial.
Iterative SVD-based frequency offset estimation with decorrelation for wireless sensor networks (2014)

This paper proposes an iterative frequency offset estimation scheme for wireless sensor networks with direct-sequence spread spectrum. The proposed scheme is able to estimate large frequency offset that may occur at the receiver on devices with a sensor by iterating singular value decomposition (SVD)-based frequency offset estimation. In the proposed estimation scheme, a decorrelator is inserted in the iteration cycle that reduces the correlation between the received signals in order to improve the estimation performance, even in multipath fading channel with co-channel interference. It is confirmed by computer simulation that the proposed estimation scheme achieves exact frequency offset estimation in the channel, even when the frequency offset normalized by the symbol duration is 7 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Framework‐Hotspot Enhanced Trans Cleavage of CRISPR‐Cas12a for Clinical Samples Detection (2023)

Abstract The trans‐cleavage property of CRISPR‐Cas12a system makes it an excellent tool for disease diagnosis. Nevertheless, most methods based on CRISPR‐Cas system still require pre‐amplification of the target to achieve the desired detection sensitivity. Here we generate Framework‐Hotspot reporters (FHRs) with different local densities to investigate their effect on trans‐cleavage activity of Cas12a. We find that the cleavage efficiency increases and the cleavage rate accelerates with increasing reporter density. We further construct a modular sensing platform with CRISPR‐Cas12a‐based target recognition and FHR‐based signal transduction. Encouragingly, this modular platform enables sensitive (100 fM) and rapid (&lt;15 min) detection of pathogen nucleic acids without pre‐amplification, as well as detection of tumor protein markers in clinical samples. The design provides a facile strategy for enhanced trans cleavage of Cas12a, which accelerates and broadens its applications in biosensing.
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases (2019)

Monooxygenases (MOs) face the challenging reaction of an organic target, oxygen and a cofactor - most commonly heme or flavin. To correctly choreograph the substrates spatially and temporally, MOs evolved a variety of strategies, which involve structural flexibility. Besides classical domain and loop movements, flavin-containing MOs feature conformational changes of their flavin prosthetic group and their nicotinamide cofactor. With similar mechanisms emerging in various subclasses, their generality and involvement in selectivity are intriguing questions. Cytochrome P450 MOs are often inherently plastic and large movements of individual segments throughout the entire structure occur. As these complicated and often unpredictable movements are largely responsible for substrate uptake, engineering strategies for these enzymes were mostly successful when randomly mutating residues across the entire structure.
Wellhead Pressure Interlock Protection (2014)

There are many pressure related issues of concern in petroleum well production. Both high and low pressure conditions are indications of problems that must be addressed to maintain well safety and performance. A flexible and reliable control system for pressure monitoring provides a failsafe interlock which prevents well operation under a variety of unsafe conditions. Proper operation of a well requires the system be maintained within a specific pressure range. The range can vary from well to well, with offshore pressures typically higher than onshore. The concept remains the same – if pressure is too high, there is a risk of catastrophic failure. If pressure is too low, it may indicate clogging or catastrophic failure at the site. Well control systems have evolved and become more sophisticated as technology and understanding have improved. Instrumentation is keeping pace and can now provide high integrity monitoring and protection with high efficiency features that increase system safety and reduce maintenance time and effort.
Two Research Projects on Infectious Diseases conducted in Noguchi Memorial Institute for Medical Research, University of Ghana by Tokyo Medical and Dental University (2013)

Ghana-Tokyo Medical and Dental University Research Collaboration Center has been established since 2008 when our Program was chosen together with the Program in the Philippines proposed by Tohoku University as an additional small-scale research center of the Overseas Research Program on Emerging and Reemerging Diseases that is funded by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government and started in 2005. This 5-year government-supported Program has changed its name to develop into a more active world-level program called Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) and entered the second 5-year phase in 2010, and our Program is playing an important role among other research centers located in Asia and Africa. Currently, two research projects are carried out in parallel in Noguchi Memorial Institute for Medical Research by Tokyo Medical and Dental University: one is a J-GRID project and the other is the one of Science and Technology Research Partnership for Sustainable Development (SATREPS) which is a joint project between Japan International Cooperation Agency (JICA) and Japan Science and Technology Agency (JST). This special article is describing what these two projects are all about.
Sustainable Hydrogen Production (2004)

Identifying and building a sustainable energy system are perhaps two of the most critical issues that today's society must address. Replacing our current energy carrier mix with a sustainable fuel is one of the key pieces in that system. Hydrogen as an energy carrier, primarily derived from water, can address issues of sustainability, environmental emissions, and energy security. Issues relating to hydrogen production pathways are addressed here. Future energy systems require money and energy to build. Given that the United States has a finite supply of both, hard decisions must be made about the path forward, and this path must be followed with a sustained and focused effort.
Fmoc‐Diphenylalanine Self Assembles to a Hydrogel via a Novel Architecture Based on π–π Interlocked β‐Sheets (2007)

The self assembly of peptide hydrogelators that carry aromatic substituents can be modeled by a novel nanocylindrical architecture. The proposed model suggests that the nanocylinders are formed by anti-parallel β-sheets interlocked by the π-stacking interactions of fluorenyl groups and phenyl rings. This explanation is consistent with the structures observed in TEM and the data obtained by a variety of spectroscopic techniques. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2008/c1221_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dry etching of deep cavities in Pyrex for MEMS applications using standard lithography (2006)

A reactive ion etching (RIE) process of Pyrex glass with a high etch rate is presented in this work, using standard lithography processes. This process enables us to create deep cavities with vertical side walls and with relatively high accuracy in Pyrex, with minimal additional process steps. An optimization of the etch process conducted using the design-of-experiment method to increase the etch rate results in an analytical model to describe the etch rate of the Pyrex. The etch rate which was optimized in this work was about 3500 A min−1 with a verticality of about 85°. Additionally, the implementation of deep cavities in Pyrex, in order to create a notch-free deep silicon etch, is presented. This is done by engineering the working material (i.e., silicon-on-glass wafer) by using Pyrex dry etch and by adding a thin metallic layer between the silicon and the Pyrex cavities.
Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs (2020)

The sustained cell proliferation resulting from dysregulation of the cell cycle and activation of cyclin-dependent kinases (CDKs) is a hallmark of cancer. The inhibition of CDKs is a highly promising and attractive strategy for the development of anticancer drugs. In particular, third-generation CDK inhibitors can selectively inhibit CDK4/6 and regulate the cell cycle by suppressing the G1 to S phase transition, exhibiting a perfect balance between anticancer efficacy and general toxicity. To date, three selective CDK4/6 inhibitors have received approval from the U.S. Food and Drug Administration (FDA), and 15 CDK4/6 inhibitors are in clinical trials for the treatment of cancers. In this perspective, we discuss the crucial roles of CDK4/6 in regulating the cell cycle and cancer cells, analyze the rationale for selectively inhibiting CDK4/6 for cancer treatment, review the latest advances in highly selective CDK4/6 inhibitors with different chemical scaffolds, explain the mechanisms associated with CDK4/6 inhibitor resistance and describe solutions to overcome this issue, and briefly introduce proteolysis targeting chimera (PROTAC), a new and revolutionary technique used to degrade CDK4/6.
Method for Extracting Management Information from (2003)

This paper gives an introduction of the method of extracting the man agement information from the title panel title block of a DWG file without the AutoCAD system AutoCAD development tools. It also analyzes the customization of the title panel title block and the algorithm during the extracting proces s.
Mapping QTLs Controlling Soybean Rust Disease Resistance in Chiang Mai 5, an Induced Mutant Cultivar (2022)

Soybean rust (SBR) caused by the fungus Phakopsora pachyrhizi is an important folia disease of soybean (Glycine max). In this study, we identified QTLs controlling SBR in Chiang Mai 5 (CM5), an SBR-resistant cultivar developed by induced mutation breeding. A recombinant inbred line (RIL) population of 108 lines developed from a cross between Sukhothai 2 (SKT2, a susceptible cultivar) and CM5 was evaluated for SBR resistance under field conditions in Thailand. QTL analysis for the resistance in the RIL population identified a single QTL, qSBR18.1, for resistance. qSBR18.1 was mapped to a 212-kb region on chromosome 18 between simple sequence repeat markers Satt288 and sc21_3420 and accounted for 21.31–35.09% depending on the traits evaluated for resistance. The qSBR18.1 interval overlapped with genomic regions containing resistance to P. pachyrhizi 4 (Rpp4), a locus for SBR resistance. Three tightly linked genes, Glyma.18G226250, Glyma.18G226300, and Glyma.18G226500, each encoding leucine-rich repeat-containing protein, were identified as candidate genes for SBR resistance at the qSRB18.1. The qSBR18.1 would be useful for breeding of SBR resistance.
Risks of Development of COVID-19 Among Patients With Inflammatory Bowel Disease: A Comparative Assessment of Risk Factors for Incident Infection (2022)

Immunosuppression use did not increase the risk of development of COVID-19. Therapeutic management of IBD should not be altered to prevent a risk of developing COVID-19.
Preparation of Gd-doped EuO1 xthin films and the magnetic and magneto-transport properties (2004)

Polycrystalline europium monoxide (EuO) films doped with and without Gd were prepared using a reactive deposition method in a MBE system. Two different electron doping methods, Gd substitution and oxygen deficiency, enhance the Curie temperature (TC) and the temperature dependence of magnetization differently. Gd doping increases TC up to 125 K, while oxygen deficient samples enhance it above 150 K. The enhanced TC is attributed to the increase in the indirect exchange interaction between Eu2+ spins via conduction electrons. The resistivities as a function of temperature for both quasi-stoichiometric (QS) EuO and QS-GdxEu1−xO show maxima near 70 and 110 K, respectively. The conduction band magnetic splitting explains the resistivity behaviours. Both the temperature dependences of the large magneto-resistance and the absorption edge are also interpreted by the conduction band magnetic splitting mechanism. The unusual blue shift observed in Gd-doped samples is not yet understood.
Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications (2015)

Prompt emergency treatment for ocular injury, particularly in a battlefield setting, is essential to preserve vision, reduce pain, and prevent secondary infection. A bandage contact lens that could be applied in the field, at the time of injury, would protect the injured ocular surface until hospital treatment is available. Cellulose, a natural polymer, is widely used in biomedical applications including bandage materials. Hydrogels synthesized from different cellulose sources, such as plants, cotton, and bacteria, can have the optical transparency and mechanical strength of contact lenses, by tailoring synthesis parameters. Thus, we optimized the fabrication of cellulose-based hydrogels and evaluated their in vivo biocompatibility and related physical properties. Our data demonstrate that along with tailorable physical properties, our novel cellulose-based hydrogels could be made with contact lens geometry, exhibit no significant signs of material toxicity after 22 days of in vivo testing, and show significant promise for use as a corneal bandage immediately following ocular trauma.
A new route to chaos: Sequences of topological torus bifurcations (2005)

We consider a sequence of topological torus bifurcations (TTBs) in a nonlinear, quasiperiodic Mathieu equation. The sequence of TTBs and an ensuing transition to chaos are observed by computing the principal Lyapunov exponent over a range of the bifurcation parameter. We also consider the effect of the sequence on the power spectrum before and after the transition to chaos. We then describe the topology of the set of knotted tori that are present before the transition to chaos. Following the transition, solutions evolve on strange attractors that have the topology of fractal braids in Poincare sections. We examine the topology of fractal braids and the dynamics of solutions that evolve on them. We end with a brief discussion of the number of TTBs in the cascade that leads to chaos.
Moisturizers: what they are and how they work. (2001)

Moisturizers are widely used in various dermatologic and cosmetic skin therapies. Different classes of moisturizers are based on their mechanism of action, including occlusives, humectants, emollients and protein rejuvenators. Commercially available moisturizers often utilize components of each of these classes to provide their beneficial effect. Dry skin (xerosis) is the major indication of use. Others include atopic dermatitis, irritant contact dermatitis, ichthyosis, and dermatoheliosis. Although generally efficacious, moisturizers can cause a number of unwanted side-effects, including occlusive folliculitis, irritation, allergic contact dermatitis and contact urticaria.