gebhart/patrepeval huggingface dataset:
Data-Driven Control Policies for Partially Known Systems via Kernelized Lipschitz Learning (2019)

Many data-driven control methodologies depend on an initial stabilizing control policy, and subsequently use operational data to refine the initial policy in order to optimize closed-loop performance. For general dynamical systems, computing such an initial policy is non-trivial, and systematic methods for this task are not available in the current literature. In this paper, we propose a systematic framework for constructing stabilizing and/or constraint-enforcing control policies for a class of nonlinear systems based on archival data. Specifically, we study partially unmodeled systems whose nonlinearities satisfy local Lipschitz conditions. We employ kernel density estimation (KDE) to learn a local Lipschitz constant from archival data, and compute control policies by solving semidefinite programs that leverage matrix multipliers informed by the Lipschitz learner. We demonstrate the potential of our proposed methodology on a nonlinear system with unmodeled dynamics.
Is Vocal Cord Asymmetry Seen on Transcutaneous Laryngeal Ultrasonography a Significant Predictor of Voice Quality Changes After Thyroidectomy? (2013)

VCA seen on TLUSG significantly correlated with "grade" and "roughness" components on the GRBAS scale and the overall VIS. Thus, VCA might be used as a surrogate of postoperative voice changes.
Multi-Scale Analyzer for Assessing Processing Uncertainty on Marine Composite Structures (2005)

The material uncertainty resulting from variability in VARTM composite material processing has driven the present design based on the “knock-down factor (factor of safety)” approach. The coarseness of marine-grade composites has prevented development of a useable process model by which the effects of the processing parameters may be predicted. There is an immediate need to assess the effect of processing uncertainty on thermal-mechanical properties and their subsequent impact on structural response, damage accumulation, and ultimate failure. In this paper, a multi-scale, probabilistic analyzer is developed by integrating the existing micromechanics-based woven fabric analysis module (TMAT) and a laminated plate solver with a probabilistic analysis framework. The effects of processing induced random constituent and microstructural parameters on the ply properties are determined first and then propagated into the laminated composite plate model. The sensitivities of these random parameters on the variability of ply and laminate stiffness matrices are also determined to identify the dominant contributor to enhance the ply/plate stiffness.
Antifungal activity of limonoids from Khaya ivorensis (2004)

Chemical investigation of the diethyl ether extract of the stem bark of Khaya ivorensis A Chev (Meliaceae) afforded ten limonoids of angolensates, ring D-opened limonoids and mexicanolides. The structures of the limonoids isolated were determined by comparison of their (1)H and (13)C NMR data with those reported in the literature. These compounds were evaluated for their antifungal activity against the plant pathogenic fungus Botrytis cinerea Pers. Methyl 6-hydroxyangolensate and 3,7-dideacetylkhivorin were also tested for their antifungal and antibacterial activities on several fungal and bacterial species. Methyl angolensate and 1,3,7-trideacetylkhivorin displayed the highest antifungal activity against B. cinerea, with respectively 62.8 and 64.0% mycelial growth inhibition at 1000 mg litre(-1), and 73.3 and 68.6% mycelial growth inhibition at 1500 mg litre(-1). 3,7-Dideacetylkhivorin showed stronger antifungal and antibacterial activities than methyl 6-hydroxyangolensate against all of the test fungi and bacteria except Penicillium expansum Link. This is the first report on the antifungal and antibacterial effects of these limonoids. Structure-antifungal activity relationships of the limonoids isolated are discussed.
Molecular Dynamics Simulations of a C<SUB>60</SUB> Molecule Adsorbed on Sinusoidal Graphene Nanoflake (2014)

We have investigated the motion of a C60 molecule absorbed on sinusoidal graphene nanoflake (GNF) via molecular dynamics simulations. Since C60 deposited on sinusoidal GNF is favorable on energetic grounds, the C60 molecule moved toward one of the valleys of sinusoidal GNF without energy barrier. So no sooner the C60 molecule was deposited on the sinusoidal GNF, then the C60 molecule immediately began to move toward the valley of the sinusoidal GNF Since the position of the C60 molecule can be changed by externally applied force fields and has a binding energy of 0.754 eV in the valley of sinusoidal GNF, the sinusoidal C60/GNF can be applied to a switchable nonvolatile memory device. This work provides the probability of alternative 'bucky shuttle' memory based on the sinusoidal C60/GNF hybrid nanostructure.
On thermal conductivity of micro‐ and nanocellular polymer foams (2013)

Abstract Many theoretical and empirical models exist to predict the effective thermal conductivity of polymer foams. However, most of the models only consider the effect of porosity, while the pore size effect is ignored. The objective of this study is to understand the effect of pore size on the thermal conductivity of polymer foams, especially when it reduces to the micro and nanometer scales. A wide range of pore sizes from 1 nm to 1 mm were studied in conjunction with the porosity effect using finite element analysis and molecular dynamics simulation methods. Experimental data was used to validate the modeling result. It is shown that the pore size has significant effect on thermal conductivity, even for microcellular and conventional foams. The contribution of heat conduction through air is negligible when pore size is reduced to the micrometer scale. The extremely low thermal conductivity of nanofoams is attributed to extensive diffusive scattering of heat carriers in the solid phase of polymer matrix, instead of air. This study provides quantitative understanding of the pore size effect on thermal conductivity of polymer foams. It is also shown that polyetherimide (PEI) nanofoams could have a thermal conductivity as low as 0.015 W/m‐K. POLYM. ENG. SCI., 2013. © 2013 Society of Plastics Engineers
Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children (2021)

Higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups.
Guidance field (2016)

A 'guidance field' is a kind of a vector field that implicitly guides users to a target point. Users' input for travelling in virtual environments is slightly altered to get closer to the target directions according to the guidance field.
Restrictions Imposed on Antibiotic Therapy by Renal Failure (1959)

When a drug which is normally excreted in large part by the kidneys is administered repeatedly to a patient with renal failure, it will tend to be retained and may accumulate in the body. The retention of large amounts of certain drugs can produce undesirable effects so that it may be prudent to reduce the size or frequency of the doses. On the other hand, undue caution may deny the patient adequate therapy and be as disadvantageous as overzealous treatment. Prolonged administration of large doses of some of the antibiotics currently in clinical use is not entirely innocuous. Liver and renal damage, negative nitrogen balance, and increased excretion of riboflavin as well as certain vitamins and amino acids into the urine may occur in patients treated with any of the tetracyclines.1-9Renal damage has been noted with the use of bacitracin,10-14the polymyxins,15-22neomycin,15,23and kanamycin.24Damage to vestibular or
Voice Controlled Stereographic Video Camera System (1989)

For several years various companies have been developing voice recognition software. Yet, there are few applications of voice control in the robotics field and virtually no examples of voice controlled three dimensional (3-D) systems. In late 1987 ARD developed a highly specialized, voice controlled 3-D vision system for use in remotely controlled, non-tethered robotic applications. The system was designed as an operator&apos;s aid and incorporates features thought to be necessary or helpful in remotely maneuvering a vehicle. Foremost is the three dimensionality of the operator&apos;s console display. An image that provides normal depth perception cues over a range of depths greatly increases the ease with which an operator can drive a vehicle and investigate its environment. The availability of both vocal and manual control of all system functions allows the operator to guide the system according to his personal preferences. The camera platform can be panned +/-178 degrees and tilted +/-30 degrees for a full range of view of the vehicle&apos;s environment. The cameras can be zoomed and focused for close inspection of distant objects, while retaining substantial stereo effect by increasing the separation between the cameras. There is a ranging and measurement function, implemented through a graphical cursor, which allows the operator to mark objects in a scene to determine their relative positions. This feature will be helpful in plotting a driving path. The image seen on the screen is overlaid with icons and digital readouts which provide information about the position of the camera platform, the range to the graphical cursor and the measurement results. The cursor&apos;s &quot;range&quot; is actually the distance from the cameras to the object on which the cursor is resting. Other such features are included in the system and described in subsequent sections of this paper.
Advancing reliability, availability, and serviceability with the IBM z13 (2015)

Each new system family brings changes from its predecessor as technologies shrink, as system structure evolves, and as requirements grow. A remap of an exceptional reliability, availability, serviceability (RAS) design from generation to generation would soon lead RAS characteristics to be inadequate. In this paper, we provide an introduction to some of changes in the IBM z13® and discuss the RAS improvements associated with these changes. We discuss the processor drawer, the memory and cache hierarchy, the I/O firmware stack, the power and thermal systems, the power and service control network, and enhancements to sparing.
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation (2022)

The aim of the present study was to develop and evaluate stabilized injection solutions of fuzapladib sodium hydrate using antioxidants as the stabilizers. To estimate the possible degradation factors and pathways of fuzapladib, forced degradation studies were conducted under thermal, acid, base, oxidative, and light conditions. To select an optimal excipient to stabilize fuzapladib under a solution state, a screening study of antioxidants was carried out to evaluate their effects to inhibit the degradation. The influence of the selected stabilizers on its pharmacokinetic behavior was evaluated in rats after intravenous administration. On the basis of data from the forced degradation study, thermal and oxidative stresses were significant factors accelerating the degradation of fuzapladib. Among eight tested antioxidants, vitamin C (VC) was the most effective stabilizer to suppress the accelerated degradation by heating, as evidenced by 45% inhibition of the degradation. The stabilization effect was enhanced depending on the concentration of VC. After the intravenous administration of fuzapladib (0.5 mg/kg) with or without VC (2.1 mg/kg), there were no significant differences between the pharmacokinetic behaviors of each group. From these findings, VC might be a promising excipient to stabilize the injection solution of fuzapladib without significant influence on its pharmacokinetic behavior.
Metabolic control of dendritic cell activation and function: recent advances and clinical implications (2014)

Dendritic cells (DCs) are key regulators of both immunity and tolerance by controlling activation and polarization of effector T helper cell and regulatory T cell responses. Therefore, there is a major focus on developing approaches to manipulate DC function for immunotherapy. It is well known that changes in cellular activation are coupled to profound changes in cellular metabolism. Over the past decade there is a growing appreciation that these metabolic changes also underlie the capacity of immune cells to perform particular functions. This has led to the concept that the manipulation of cellular metabolism can be used to shape innate and adaptive immune responses. While most of our understanding in this area has been gained from studies with T cells and macrophages, evidence is emerging that the activation and function of DCs are also dictated by the type of metabolism these cells commit to. We here discuss these new insights and explore whether targeting of metabolic pathways in DCs could hold promise as a novel approach to manipulate the functional properties of DCs for clinical purposes.
POP: an efficient Performance OPtimization algorithm based on integrated approach (2002)

This paper presents an efficient performance optimization algorithm, which overcomes the drawbacks of previous approaches and can be used to produce high performance circuits without modifying the topology of the circuit. In contrast with previous approaches, the algorithm selects the minimum number of components to be optimized with vastly improved times while considering the functionality of components exactly at the same time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and fabrication of a cMUT probe for ultrasound imaging of fingerprints (2010)

Optical fingerprint scanners suffer from limited depth of penetration and are particularly sensitive to the surface conditions of the skin. Fingerprint scanners based on ultrasounds offer the possibility to explore the surface and the underlying tissues of the finger and to detect blood flow, leading to enhanced robustness and reliability in biometric applications. Capacitive Micromachined Ultrasonic Transducers (cMUTs) have shown to have great potential for use in medical imaging applications. The ease of fabricating broadband high-frequency ultrasound transducers makes the cMUT technology a good candidate for ultrasound based biometrics. This paper presents the design, fabrication and characterization of a cMUT linear array probe optimized for near-field ultrasound imaging. Ultrasound images of fingerprints are obtained using a customized 3D ultrasound scanning system.
Mechanism of Sequential Swallowing During Straw Drinking in Healthy Young and Older Adults (2004)

Recent research has revealed differences between isolated and sequential swallowing in healthy young adults; however, the influence of normal aging on sequential swallowing has not been studied. Thus, the purpose of this investigation was to examine the effects of normal aging on deglutition during sequential straw drinking. Videofluoroscopic samples of two 10-s straw drinking trials were obtained for 20 healthy young men (age 29 +/- 3 years) and 18 healthy older men (age 69 +/- 7 years). Hyolaryngeal complex (HLC) movement patterns, leading edge of the bolus location at swallow onset, and occurrences of airway invasion were determined. Two HLC patterns were identified: (a). HLC lowering with the epiglottis returned to upright between swallows and (b). partially maintained HLC elevation with the epiglottis inverted between swallows. The bolus was frequently in the hypopharynx at swallow onset. Strong associations were identified between age and HLC pattern, age and leading edge of the bolus location, and HLC pattern and leading edge location. Laryngeal penetration was uncommon overall; however, it occurred more frequently in the older adults than in the young adults. A significant relation was identified between age and the average Penetration-Aspiration Scale score. Laryngeal penetration was associated with both HLC movement patterns and hypopharyngeal bolus location, particularly in older adults. Results indicate that subtle age-related differences are evident in healthy young and older adults with sequential straw drinking. These data suggest that specific inherent swallowing patterns may increase the risk of laryngeal penetration with normal aging.
Necrotizing Soft Tissue Infections (2014)

Journal of the American College of Surgeons 218(2):p 302-303, February 2014. | DOI: 10.1016/j.jamcollsurg.2013.10.018
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin (2012)

Diabetes mellitus (DM) is associated with increased platelet activation and reduced platelet inhibition by clopidogrel. Prostaglandin E1 (PGE1) stimulates adenyl cyclase activity in platelets and increases cyclic AMP concentrations, which inhibit Ca(2+)release and platelet aggregation induced by P2Y1 receptor activation. PGE1 is included in the VerifyNow P2Y12 assay to suppress P2Y1 induced platelet aggregation. We hypothesized that diabetes mellitus may be associated with altered response to PGE1 in subjects treated with clopidogrel. Subjects with established coronary artery disease who were taking clopidogrel 75 mg daily and aspirin for >14 days were enrolled (n = 96). Diabetic (n = 34) were compared with non-diabetic subjects (n = 62). VerifyNow P2Y12 assay and light transmittance aggregometry (LTA) were performed using ADP as agonist with and without addition of PGE1. Genomic DNA was genotyped for common cytochrome P450 (CYP) 2C19 variants using Taqman assays. Residual on-treatment platelet aggregation induced by 20 µM ADP was not significantly different between subjects with and without DM. Addition of 22 nM and 88 nM PGE1 to 20 µM ADP resulted in a significant reduction of maximal platelet aggregation (MPA). Residual LTA platelet aggregation with PGE1 and VerifyNow P2Y12 platelet reactivity were significantly higher in subjects with DM than those without DM and in carriers of CYP 2C19*2 polymorphism. We conclude that an impaired inhibitory response to PGE1 may contribute to the high platelet reactivity phenotype in subjects with DM treated with clopidogrel. Addition of PGE1 to ADP agonist platelet assays may identify subjects with blunted inhibitory response to prostaglandins and result in a higher proportion of subjects with DM being classified as non-responders.
Comparative genome analysis of rice-pathogenic Burkholderia provides insight into capacity to adapt to different environments and hosts (2015)

The complete genome sequence of B. plantarii ATCC 43733T and publicly available genomes of B. glumae BGR1 and B. gladioli BSR3 enabled comprehensive comparative genome analyses among three rice-pathogenic Burkholderia species responsible for tissue rotting and seedling blight. Our results suggest that B. glumae has evolved rapidly, or has undergone rapid genome rearrangements or deletions, in response to the hosts. It also, clarifies the unique features of rice pathogenic Burkholderia species relative to other animal and human Burkholderia species.
Formation of the [b + 41]+˙ ion in the mass spectra of 2-thiouridines (1980)

In the electron impact mass spectra of some 2-thiouridines a prominent base +41 (b+C2HO) peak was found. The sulphur atom at the 2 position facilitates its formation.
Fracture systems and mesoscale structural patterns in the siliciclastic mesozoic reservoir-caprock succession of the longyearbyen CO2 lab project: Implications for geological CO2 sequestration in central spitsbergen, svalbard (2014)

In unconventional, naturally fractured reservoirs, networks of structural discontinuities largely control fluid flow. In this study, we mapped and analysed systematic fracture patterns within the Mesozoic succession of Central Spitsbergen to characterise the reservoir-caprock system explored for geological CO2 storage by the Longyearbyen CO2 Lab project. We carried out and integrated structural and stratigraphic analyses of outcrop and borehole data, subdividing the investigated sedimentary interval into five litho-structural units (LSUs): (A) massive to laminated shales characterised by predominant low-angle fractures, (B) heterogeneous, fine-grained intervals with both lowand high-angled fractures, (C) massive, coarsegrained intervals dominated by high-angle fractures, (D) igneous intrusions characterised by synand post-emplacement fractures and veins, and (E) carbonate beds dominated by high-angle fractures and veins. LSUs are identified on the basis of their fracture associations, lithologies and dominant sedimentary facies, and thus implicitly include information on the primary porosity and permeability. In general, two main, subvertical extensional fracture sets are recognised: (i) a principal fracture set trending approximately NE-SW to ENE-WSW (J1) and (ii) a subordinate fracture set trending about NNW-SSE to NNE-SSW (J2). Conjugate shear fractures (S1) are trending roughly NE-SW and NW-SE in the coarser-grained and more cemented lithologies. A low-angle fracture set (S2) striking approximately NNW-SSE to WNW-ESE is also observed. Variations in fracture patterns suggest that the LSUs are pseudo-mechanical units, which are able to steer, baffle or impede horizontal and vertical fluid migration due to their primary matrix (i.e., grain size and mineralogy) and fracture network properties. At a larger scale, the resultant stratigraphic and structural architecture controls the hydrogeological regime of the investigated reservoir-caprock succession, providing: (1) fracture-related secondary porosity and permeability, (2) enhanced microfracturing matrix connectivity, and (3) preferential directions of subsurface fluid-flow pathways. We conclude that, given the present-day stress field, subsurface fluid flow would be augmented in an ENE-WSW trend, with possible additional NE-SW communication.
Data transmission from an implantable biotelemeter by load-shift keying using circuit configuration modulator (1995)

Using the reflected impedance property of an inductive couple (transformer), a modulation method, load-shift keying using circuit configuration modulator (LSK-CCM), was developed to perform data transmission from an implantable telemeter. With a very simple circuit, this method utilizes a radio-frequency electromagnetic field induced with a single pair of coils to transmit power into the implant and data out of it.