gebhart/patrepeval huggingface dataset:
Production of monoclonal antibodies against calmodulin by in vitro immunization of spleen cells. (1983)

Monoclonal antibodies against the highly conserved ubiquitous calcium-binding protein, calmodulin (CaM), were produced by immunization of mouse primary spleen cell cultures. Dissociated spleen cells were cultured for 5 d in the presence of mixed thymocyte culture conditioned media (TCM) and purified bovine testes CaM (50 ng-1 mg). Following immunization, cells were fused with mouse myeloma cells (SP2/0, Ag 8.653) and cultured for 2-3 wk before initial screening for antibody. In five independent immunizations there was a range of 25-44% of the initial polyclonal cultures which produced antibodies reacting with purified CaM as determined by immunoassay. 80% of the cloned hybridoma produced IgM immunoglobulins while the remaining clones were IgG producers. This ratio was changed to 50% IgM and 50% IgG by subsequent extension of the in vitro immunization periods and reduced amounts of antigen and extended in vitro culturing. In vitro immunization introduces a new dimension to monoclonal antibody production where limited antigen or poorly antigenic proteins are of interest. The monoclonal antibodies produced in this study have enabled us to to selectively localize CaM in association with distinct subcellular structures, mitochondria, stress fibers, centrioles, and the mitotic spindle.
High-Throughput Layered LDPC Decoding Architecture (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a high-throughput decoder architecture for generic quasi-cyclic low-density parity-check (QC-LDPC) codes. Various optimizations are employed to increase the clock speed. A row permutation scheme is proposed to significantly simplify the implementation of the shuffle network in LDPC decoder. An approximate layered decoding approach is explored to reduce the critical path of the layered LDPC decoder. The computation core is further optimized to reduce the computation delay. It is estimated that 4.7 Gb/s decoding throughput can be achieved at 15 iterations using the current technology. </para>
Potentiation of lysis of leukaemia cells by a bispecific antibody to CD33 and CD16 (FcγRIII) expressed by human natural killer (NK) cells (1995)

Bispecific antibodies recognizing tumour-associated antigens and trigger molecules expressed on immune effector cells have been shown to redirect cytotoxicity of several types of peripheral blood cells against relevant tumour targets. Among various effector cells, natural killer (NK) cells appear to play a role in defence against leukaemia. Here we report the successful chemical conjugation of monoclonal antibodies to CD33 and CD16 to create a bispecific antibody (BsAb 251 x 3G8). This bispecific antibody is capable of augmenting the killing of otherwise resistant leukaemia cells by peripheral blood lymphocytes (PBL), purified resting NK (R-NK) cells, and activated NK (A-NK) cells. BsAb 251 x 3G8 may play a role in the therapy of acute myeloid leukaemia (AML) through redirecting the cytotoxic activity of endogenous or adoptively transferred NK cells.
PREVALENCE RATES OF UTERINE CERVICAL CARCINOMA IN SITU FOR WOMEN USING THE DIAPHRAGM OR CONTRACEPTIVE ORAL STEROIDS (1970)

Melamed, Myron R.; Koss, Leopold G.; Flehinger, Betty J.; Kelisky, Richard P.; Dubrow, Hilliard Author Information
Alternative Lead Positioning in the Right Ventricular Outflow Tract in Transvenous Implantation of ICDs (1995)

Pacing and sensing failure in apical right ventricular coil electrode PCD implantation due to ventricular scars or aneurysma may force the implanting surgeon to switch to more invasive procedures such as subxyphoidal pericardiotomy or thoracotomy for epimyocardial corkscrew electrode and for epicardial patch application. In order to avoid this more invasive operation in the most severely impaired patients, right ventricular outflow tract positioning of the RV electrode is suggested as an alternative RV electrode site for implantation. A study of four cases shows that this occasional procedure is a practicable method to avoid more invasive techniques. Excellent pacing, sensing, and defibrillation characteristics were obtained and application is relatively simple.
Optimum Design of a Compliant Uniaxial Accelerometer (2008)

This work focuses on the multi-objective optimization of a compliant-mechanism accelerometer. The method is used to optimally design an accelerometer with the architecture of a novel version of the Sarrus mechanism. The purpose is to maximize the sensitivity of the accelerometer in its sensing direction, while minimizing its sensitivity in all other directions. The paper starts with a brief description of the dynamics model of the compliant mechanism, followed by the formulation of the a posteriori multi-objective optimization. By using the normalized constrained method, an evenly distribution of the Pareto frontier is found. The paper also provides several optimum solutions on a Pareto plot, as well as the CAD model of the selected solution.
TAp73 isoforms antagonize Notch signalling in SH‐SY5Y neuroblastomas and in primary neurones (2006)

p73, like Notch, has been implicated in neurodevelopment and in the maintenance of the mature central nervous system. In this study, by the use of reporter-gene assays, we demonstrate that C-promoter binding factor-1 (CBF-1)-dependent gene transcription driven by the Notch-1 intracellular domain (N1(ICD)) is potently antagonized by exogenously expressed transactivating (TA) p73 splice variants in SH-SY5Y neuroblastomas and in primary neurones. Time course analysis indicated that the inhibitory effects of TAp73 are direct and are not mediated via the product of a downstream target gene. We found that endogenous TAp73 stabilized by either c-Abl or cisplatin treatment also potently antagonized N1(ICD)/CBF-1-dependent gene transcription. Furthermore, western blotting revealed that exogenous TAp73 suppressed endogenous hairy and enhancer of split-1 (HES-1) protein levels and antagonized the increase in HES-1 protein induced by exogenous N1(ICD) expression. Evidence of a direct physical interaction between N1(ICD) and TAp73alpha was demonstrated by co-immunoprecipitation. Using Notch deletion constructs, we demonstrate that TAp73alpha binds the N1(ICD) in a region C-terminal of aa 2094. Interestingly, DeltaNp73alpha and TAp73alpha(R292H) also co-purified with N1(ICD), but neither inhibited N1(ICD)/CBF-1-dependent transcription. This suggests that an intact transactivation (TA) domain and the ability to bind DNA are necessary for TAp73 to antagonize Notch signalling. Finally we found that TAp73alpha reversed the N1(ICD)-mediated repression of retinoic acid-induced differentiation of SH-SY5Y neuroblastomas, providing functional evidence for an inhibitory effect of TAp73alpha on notch signalling. Collectively, these findings may have ramifications for neurodevelopment, neurodegeneration and oncogenesis.
Towards a sensor network architecture: lowering the waistline (2005)

Wireless sensor networks have the potential to be tremendously beneficial to society. Embedded sensing will enable new scientific exploration, lead to better engineering, improve productivity, and enhance security.
Predicting a binary sequence almost as well as the optimal biased coin (1996)

We apply the exponential weight algorithm, totically optimal in that case) is only 1/2. We show that this gap of 1/2 is necessary by calculating the regret of the min-max optimal algorithm for this problem and showing that the asymptotic upper bound is tight. We also study the application of this algorithm to the square loss and show that the algorithm that is derived in this case is different from the Bayes algorithm and is better than it for prediction in the worst-case.
2P1-N-043 A model of robotic body schema extension and implementation : Based on synchrony among multi-modal sensation(Cognitive Robotics 2,Mega-Integration in Robotics and Mechatronics to Assist Our Daily Lives) (2005)

( Kobe Univ )
Experiencia inicial en el tratamiento endovascular de los aneurismas de la aorta abdominal en un servicio de cirugía cardiovascular. Valoración de la curva de aprendizaje (2006)

El empleo de endoprótesis en el tratamiento de los aneurismas de la aorta abdominal AAA es un procedimiento cada vez más frecuente. Analizar el impacto de la curva de aprendizaje en la puesta en marcha de un programa de tratamiento endovascular de los AAA en un servicio de cirugía cardiovascular. Se incluyen los primeros 58 pacientes consecutivos con AAA tratados mediante endoprótesis. Todos los enfermos eran varones, con una edad media de 73,2 años y de alto riesgo anestésico y quirúrgico. Las intervenciones fueron efectuadas por cirujanos cardiovasculares y radiólogos. Se pudo completar el procedimiento en todos los casos. En dos ocasiones se produjo una lesión del acceso arterial precisando un abordaje retroperitoneal para su control. En el postoperatorio inmediato un paciente falleció debido a una isquemia intestinal (1,7%). El seguimiento medio fue de 8,97 meses/paciente (1–32 meses), no presentándose durante el mismo roturas aneurismáticas, ni reconversiones a cirugía abierta, ni muertes en relación con el dispositivo o el procedimiento. Un paciente precisó la colocación de una extensión proximal por una endofuga tipo I y otro enfermo una derivación femorofemoral por una trombosis de rama protésica. Con la colaboración de cirujanos cardiovasculares y radiólogos, y el adecuado asesoramiento de expertos en los primeros casos realizados, el inicio en el tratamiento endovascular de los AAA puede afrontarse con garantías de éxito minimizando los efectos de la curva de aprendizaje. The number of cases of abdominal aortic aneurysms treated with an endovascular stent-graft prosthesis is steadily increasing. Objectives. To analyse the impact of the learning curve in a starting program of endovascular treatment of AAA in a cardiovascular surgery service. Fifty-eight patients with AAA, all males, at high risk for conventional surgical therapy were treated with endovascular grafts. Mean age was 73.2 years. All interventions were performed by cardiovascular surgeons and interventional radiologists. The aneurysmal sac was excluded in all cases. Retroperitoneal dissection was performed to repair the arterial access in two cases. Early mortality was 1.7% (an 83-year-old man with intestinal ischemia). Mean follow-up was 8.97 months (1–32). There were no aneurysmal ruptures, conversions to open surgery or procedure-related deaths in the follow- up. A proximal graft extension was implanted for a type 1 endoleak and a femorofemoral bypass was performed after an iliac branch thrombosis. With the cooperation between cardiovascular surgeons and interventional radiologists and the appropriate advice given by experts, a successfully program of AAA endovascular treatment can start minimizing the effects of the learning curve.
Perceived Autonomy Support, Motivation Regulations and the Self-Evaluative Tendencies of Student Dancers (2011)

Limited research has considered the social-environmental and motivational processes predictive of self evaluations and body-related concerns. Evidence suggests that low self-esteem, poor body evaluations, and associated anxieties are particularly prevalent among the student dance population. Grounded in self-determination theory (SDT), this study examined the relationships among perceptions of autonomy support, motivation regulations, and self-evaluations of body-related concerns in the context of vocational dance. Three hundred and ninety-two dancers completed questionnaires regarding their perceptions of autonomy support in their dance school, reasons for engaging in dance, self-esteem, social physique anxiety (SPA), and body dissatisfaction. Structural equation modeling analyses revealed that perceived autonomy support predicted intrinsic motivation (+) and amotivation (-). Extrinsic regulation positively predicted SPA. Amotivation mediated the associations between perceptions of autonomy support and dancers' self-esteem, SPA, and body dissatisfaction. The utility of SDT in understanding predictors of self-worth, physical evaluations, and associated concerns was supported. Moreover, this study provides preliminary evidence supporting the applicability of SDT in dance contexts.
Tc-99m-MAG3 CLEARANCE BY CAMERA METHOD IN RENAL ALLOGRAFTS (1997)

Lamki, Naifa; Roberts, Ashley; Lamki, Lamk; Barron, Bruce; Chueh, Shih-Chieh; Ephron, Vick; Kahan, Barry D. Author Information
Encephalitis in the 21 st century. (2000)

As the 21st century begins, several outbreaks of encephalitis have been reported. An examination of these outbreaks brings into focus important epidemiological developments. Specifically, urbanization and encroachment on natural environments, the ease of world travel, and global trade can lead to spread of vectors and viruses from the developing world to the developed world. This review focuses on two recent epidemics of encephalitis: West Nile virus encephalitis in the eastern United States and Nipah virus encephalitis in Malaysia and Singapore. These examples demonstrate spread of a known viral agent from an endemic area to an area in which it had not previously been found and identification of a new viral agent. Infectious diseases in the developed world once considered "exotic" are now potential threats to all patients.
Quality Costing (2015)

Abstract Quality costing expresses an organization's quality performance in financial terms.
Accurate evaluation of HER-2 amplification in FISH images (2010)

Fluorescence in situ hybridization (FISH) is a cytogenetic technique used to detect the presence of specific DNA sequences on chromosomes. An application of FISH targets the measurement of the amplification of the HER-2 gene within the chromosomes. This requires computation of the ratio of HER-2 over centromere 17 (CEP-17) markers detected within a representative number of nuclei. Selection of the nuclei that are used to compute this ratio is a crucial step to yield an accurate estimation of HER-2 amplification. In fact, errors deriving from overlapping, clustered and oversegmented nuclei can bias the estimation of the ratio and yield inaccurate evaluation of HER-2 amplification. In this paper, a model is presented to associate a reliability score with each nucleus. The reliability score enables refinement of segmentation results - yielding more accurate identification of the boundary of each nucleus - as well as ranking of detected nuclei so as to use just the most reliable nuclei to compute the ratio. Experimental results demonstrate that the adoption of the proposed model improves the estimation of HER-2 amplification.
Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors (2016)

Cell-cell interactions play crucial roles in the maintenance of tissue homeostasis, a loss of which often leads to varying diseases, including cancer. Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell communication. Previously, we reported reproductive phenotypes of transgenic mice, in which expression of constitutively active mutant PI3K was induced in primordial oocytes by Gdf9-iCre. The transgenic mice (Cre(+)) demonstrated severe ovarian phenotypes, including the overgrowth of excess ovarian follicles and anovulation. Surprisingly, the Cre(+) mice became cachectic by postnatal day 80 due to bilateral GCT. Although GCT cells proliferated independently of oocytes, local interactions with mutant PI3K-positive oocytes during early folliculogenesis were essential for the GC transformation. Growing GCT cells expressed high levels of inhibin βA and nuclear SMAD3, and the proliferation rate was positively correlated with a high activin A to inhibin A ratio. These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathway, a hypothesis confirmed by activin A secretion in cultured GCT cells, which proliferated in response. Although communication between the oocyte and surrounding somatic cells is critical for the normal development of ovarian follicles, perturbations in oocyte-GC communication during early folliculogenesis can induce GCT by activating an autocrine growth circuit program in GC. Cancer Res; 76(13); 3851-61. ©2016 AACR.
Multicenter Pivotal Study of Vacuum-Assisted Precise Tissue Release for the Treatment of Cellulite (2015)

This study demonstrates the safety, efficacy, and subject satisfaction with vacuum-assisted precise tissue release in the treatment of cellulite. There was no reduction in treatment benefits for up to 1 year. These results supported the Food and Drug Administration clearance of the device for the long-term reduction in the appearance of cellulite.
Rapid wide-field imaging through scattering media by digital holographic wavefront correction (2019)

Imaging through scattering media has been a long standing challenge in many disciplines. One of the promising solutions to address the challenge is the wavefront shaping technique, in which the phase distortion due to a scattering medium is corrected by a phase modulation device such as a spatial light modulator (SLM). However, the wide-field imaging speed is limited either by the feedback-based optimization to search the correction phase or by the update rate of SLMs. In this report, we introduce a new method called digital holographic wavefront correction, in which the correction phase is determined by a single-shot off-axis holography. The correction phase establishes the so-called &#x201C;scattering lens&#x201D;, which allows any objects to be imaged through scattering media; in our case, the &#x201C;scattering lens&#x201D; is a digital one established through computational methods. As no SLM is involved in the imaging process, the imaging speed is significantly improved. We have demonstrated that moving objects behind scattering media can be recorded at the speed of 2.8&#x00A0;fps with each frame corrected by the updated correction phase while the image contrast is maintained as high as 0.9. The image speed can potentially reach the video rate if the computing power is sufficiently high. We have also demonstrated that the digital wavefront correction method also works when the light intensity is low, which implicates its potential usefulness in imaging dynamic processes in biological tissues.
Optimal Emitter Cell Geometry in High Power 4H-SiC BJTs (2015)

Three 4H-SiC bipolar junction transistor designs with different emitter cell geometries (linear interdigitated fingers, square cell geometry, and hexagon cell geometry) are fabricated, analyzed, and compared with respect to current gain, ON-resistance (RON), current density (JC), and temperature performance for the first time. Emitter size effect and surface recombination are investigated. Due to a better utilization of the base area, optimal emitter cell geometry significantly increases the current density about 42% and reduces the ON-resistance about 21% at a given current gain, thus making the device more efficient for high-power and high-temperature applications.
Toll-like receptors: New targets for multiple myeloma treatment? (2022)

Despite recent biomedical improvements in treating multiple myeloma, this disease still remains incurable. Toll-like receptors (TLRs) are key immune receptors that recognize conserved molecular patterns expressed by pathogens and damaged cells. Activation of TLRs can induce several effects including inflammatory responses, modulation of cell cycle, apoptosis, or regulation of cell metabolism. In multiple myeloma there is a dysregulated signalling of TLRs due to an abnormal presence of certain pathogens and release of molecules from damaged cells. Thus, TLRs could be critical players for tumour microenvironment and multiple myeloma progression. This haematological malignancy is characterized by a high percentage of recurrences, where many patients can develop residual drug-resistant malignant cells. Strategic targeting of TLRs might result in novel therapeutic combinations that improve the response to current treatments, reducing relapses. This review examines the potential of TLRs as targets for the treatment of multiple myeloma, making a particular emphasis on their therapeutic applications.
Electrostatic studies of π–π interaction for benzene stacking on a graphene layer (2011)

Recently, aromatic molecules have been stacked on graphene for applications in biosensors and chemical sensors, although the interaction between them is not well understood. In this paper, we use electrostatic model, double charge rings, and its image charges model to simulate the π–π interaction between benzene and a graphene layer. Furthermore, the results of our model are confirmed by the numerical results from density functional theory and experimental reviews. This model has potential for use in predicting the interactions between aromatic molecules and graphene.
A Tour of Convolutional Networks Guided by Linear Interpreters (2019)

Convolutional networks are large linear systems divided into layers and connected by non-linear units. These units are the "articulations" that allow the network to adapt to the input. To understand how a network manages to solve a problem we must look at the articulated decisions in entirety. If we could capture the actions of non-linear units for a particular input, we would be able to replay the whole system back and forth as if it was always linear. It would also reveal the actions of non-linearities because the resulting linear system, a Linear Interpreter, depends on the input image. We introduce a hooking layer, called a LinearScope, which allows us to run the network and the linear interpreter in parallel. Its implementation is simple, flexible and efficient. From here we can make many curious inquiries: how do these linear systems look like? When the rows and columns of the transformation matrix are images, how do they look like? What type of basis do these linear transformations rely on? The answers depend on the problems presented, through which we take a tour to some popular architectures used for classification, super-resolution (SR) and image-to-image translation (I2I). For classification we observe that popular networks use a pixel-wise vote per class strategy and heavily rely on bias parameters. For SR and I2I we find that CNNs use wavelet-type basis similar to the human visual system. For I2I we reveal copy-move and template-creation strategies to generate outputs.
Photocaged Competitor Guests: A General Approach Toward Light‐Activated Cargo Release From Cucurbiturils (2017)

A general approach toward the light-induced guest release from cucurbit[7]uril by means of a photoactivatable competitor was devised. An o-nitrobenzyl-caged competitor is photolyzed to generate a competitive guest that can displace cargo from the host macrocycle solely based on considerations of chemical equilibrium. With this method the release of terpene guests from inclusion complexes with cucurbit[7]uril was demonstrated. The binding of the herein investigated terpenes, all being lead fragrant components in essential oils, has been characterized for the first time. They feature binding constants of up to 10<sup>8</sup> L mol<sup>-1</sup> and a high differential binding selectivity (spanning four orders of magnitude for the binding constants for the particular set of terpenes). By fine-tuning the photoactivatable competitor guest, selective and also sequential release of the terpenes was achieved.