gebhart/patrepeval huggingface dataset:
A new genetic assay for color vision deficiency outperforms behavioral tests (2011)

The Sequenom MassArray instrument allows genotyping at known polymorphic sites using specially designed PCR primers followed by mass spectrometry. This technique is ideally suited to diagnosis of color vision deficiency, a condition whose genetic underpinnings are well understood. Though it does not provide a full gene sequence, the MassArray replaces a cumbersome, multistep PCR while still offering accurate, detailed analysis of the cone opsin genes that underlie color vision. The multiplexed assay format allows rapid, high throughput genetic characterization of cone opsin array length and composition in a single well. In preliminary results from 46 subjects, the MassArray easily distinguished normal individuals from those with anomalous color vision and correctly classified protanopes, deuteranopes, deuteranomalous and protanomolous individuals, and female carriers. Color vision diagnosis including presence vs. absence, type and severity using the MassArray is more accurate than behavioral color vision tests such as the HRR, Dvorine, and Ishihara pseudoisochromatic plates, the Farnsworth-Munsell D15 and the anomaloscope. Genetic screening with the MassArray maintains high accuracy eliminating the need for experimenter training and lengthy subject testing while removing inconsistencies from variability in spectral content and intensity of illumination, viewing distance, communication problems and cheating that can decrease the reliability of behavioral tests.
Investigation of the Stability of the M‐H‐B Bond in Borane σ Complexes [M(CO)5(η1‐BH2R⋅L)] and [CpMn(CO)2(η1‐BH2R⋅L)] (M=Cr, W; L=Tertiary Amine or Phosphine): Substituent and Lewis Base Effects (2007)

We investigated the influence of a substituent and a Lewis base on boron upon the thermodynamic stability of metal complexes of borane-Lewis base adducts, [M(CO)5(eta1-BH(2)R.L)] (M=Cr, W) and [CpMn(CO)2(eta1-BH2R.L)], where R=Cl, I, m-C6H4F, Ph, H, Me, Et; L=PMe3, PPh3, NMe3, quinuclidine. In these compounds, the stability of the metal-borane linkage was enhanced by increasing the electron-releasing ability of the substituent on boron. A stronger base L additionally stabilized the complexes. The strength of the borane-metal interaction is thus mainly ascribed to the electron donation from the BH sigma orbital to metal rather than the back-donation into the BH sigma* orbital. This result supports the bonding model for the B-H-M linkage in the borane complexes suggested by MO calculations, where the borane-to-metal electron donation is predominant while the metal back-donation into the BH sigma* orbital is negligible. Such a stability trend of the borane complexes makes a sharp contrast to that of many silane and dihydrogen complexes.
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. (1995)

The maturation of epidermal keratinocytes is a tightly regulated, stepwise process which requires protein kinase C (PKC) activation. We investigated the effect of elevated extracellular Ca2+, a potent differentiation signal which increases cellular sn-1,2-diacylglycerol levels, on the PKC isozyme profile of cultured murine keratinocytes. Five PKC isozymes (alpha, delta, epsilon, zeta, and eta) were detected by immunoblotting. During Ca(2+)-induced differentiation, total cellular PKC alpha decreased, PKC epsilon and eta increased 3-5-fold, and the level of other PKC isozymes was relatively unchanged. PKC alpha underwent a progressive translocation from the soluble to the particulate fraction following elevation of extracellular Ca2+. The kinetics of PKC alpha translocation corresponded with the induction of keratinocyte differentiation markers. Both PKC delta and epsilon were selectively lost from the soluble fraction of keratinocytes exposed to elevated extracellular Ca2+, resulting in an increase in the proportion of these isoforms in the particulate fraction. PKC eta increased in both the soluble and particulate fractions, while PKC zeta did not change in amount or distribution during keratinocyte differentiation. Selective down-regulation of PKC isoforms by either 12-deoxyphorbol-13-phenylacetate or bryostatin 1 inhibited Ca(2+)-induced expression of differentiation markers at doses most specific for the down-regulation of PKC alpha. Taken together, these observations suggest that the induction of keratinocyte differentiation by Ca2+ results in the activation of specific PKC isozymes.
Dual-Attention Sparse R-CNN via Single ROI Transformer and Dynamic CBAM (2022)

A critical drawback of CNN-based object detection is an additional post processing such as non-maximum suppression(NMS). Recent works have solved that problem by applying a vision transformer, which is able to make sparse correlation between feature maps and proposal embedding. Sparse R-CNN, which is end-to-end object detection network, applies dynamic convolution for the correlation but requires many parameters. Based on the sparse R-CNN, this paper presents a dual-attention module for accurate and efficient end-to-end object detection. The proposed dual-attention method consists of: i) dynamic CBAM, which is more efficient than dynamic convolution and ii) single ROI transformer. Experimental results show that the proposed method not only is efficient in the sense of reduced number of parameters but also improves the performance.
Contaminant cloud boundary monitoring using network of UAV sensors (2008)

We describe research work currently being undertaken to detect, model, and track the shape of a contaminant cloud boundary using air borne sensor swarms. A model of the contaminant cloud boundary is first developed using a splinegon, defined by a set of vertices linked by segments of constant curvature. This model is then used in an estimator to predict the evolution of the contaminant cloud. This approach is efficient in that only the vertices and segment curvatures are required to define the cloud boundary, rather than using a distribution function to represent the dispersion density.
Investigation of the Sound Transmission into an Advanced Grid-Stiffened Structure (2003)

The noise transmission behavior of an advanced grid-stiffened (AGS) composite structure has been investigated by combining numerical and experimental methods. Structural-acoustic coupling was found to be light, permitting separate analysis of the structure and acoustic cavity. Finite element analysis permitted the resonant frequencies of acoustic cavity and structure to be calculated, which play an important role for noise transmission through the structure. Acoustic mode shapes permitted internal coincidence frequencies to be estimated and provided insight into modal pressure distributions, when considering payload location. Experimental structural and acoustic modal analysis permitted the resonant frequencies and damping ratios for the structure and cavity to be determined, which in turn were used to corroborate the FEA model. Finally, direct measurement of the noise transmission was performed based on noise reduction spectrum (NRS), which is calculated from spatial averages of the RMS acoustic pressures inside and outside of the shell. It was found that the NRS was dominated by acoustic resonances, which were marked by sharp dips in the NRS curve. Internal coincidence of the axial wavenumbers was also found to be a significant mechanism for noise transmission. External coincidence and ring frequencies were found to provide less of an impact on the overall NRS for the structure.
PREFACE (1975)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPREFACEJOHN B. PFEIFFERJOHN B. PFEIFFERAllied Chemical Corp. Morristown, N.J. October, 1974More by JOHN B. PFEIFFERDOI: 10.1021/ba-1975-0139.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):April 1, 1975Publication History Published online22 July 2009Published inprint 1 April 1975Request reuse permissions Copyright © 1975 AMERICAN CHEMICAL SOCIETY. This publication is available under these Terms of Use. Sulfur Removal and Recoveryp ixAdvances in ChemistryVol. 139ISBN13: 9780841202177eISBN: 9780841223202Chapter Views52Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (157 KB) Get e-Alerts
Enzyme-Linked Immunospot Assay Responses to Early Secretory Antigenic Target 6, Culture Filtrate Protein 10, and Purified Protein Derivative among Children with Tuberculosis: Implications for Diagnosis and Monitoring of Therapy (2005)

Tuberculosis-specific ELISPOT testing is a promising tool that should be evaluated as a potential diagnostic test for childhood tuberculosis. We caution against the use of an early decrease in response as a marker of successful antituberculous chemotherapy.
Dual-modality imaging of a compressible breast phantom with realistic optical and x-ray properties (2010)

Medical imaging equipment is routinely characterised and tested using tissue equivalent phantoms. Combined x-ray and optical mammography could provide increased screening specificity over either system alone. The ongoing evaluation of this approach depends upon the development of phantoms with simultaneously breast tissue equivalent optical and x-ray properties. Furthermore deformation models used in the registration of optical and x-ray images, which are acquired at differing levels of breast compression, require validation through phantoms which are also mechanically tissue equivalent. As well as static imaging, dynamic optical imaging of blood flow whilst breast compression is applied has been proposed as a method of enhancing screening specificity. The effect of changes in blood flow and volume on optical tomography still need to be established. A novel phantom material created by freezing and thawing a solution of polyvinyl alcohol (PVAL) in ethanol to create a solid yet elastically compressible gel is described. These gels have x-ray attenuation coefficients equivalent to those of breast tissues whilst their optical and mechanical properties are readily modified. Titanium dioxide is added to the optically non-scattering and colourless gels to obtain the transport scattering coefficient required. Cancerous tissues are often many times stiffer than healthy. Similar differences in stiffness are achieved between gels by varying PVAL concentration. The first x-ray and optical images of an anthropomorphically shaped breast phantom made from this gel are presented. This contains a lesion filled with blood equivalent dye whose volume changes upon compression of the phantom.
Sizing Extracellular Vesicles Using Membrane Dyes and a Single Molecule-Sensitive Flow Analyzer (2021)

Extracellular vesicles (EVs) are membranous particles released by most cells in our body, which are involved in many cell-to-cell signaling processes. Given the nanometer sizes and heterogeneity of EVs, highly sensitive methods with single-molecule resolution are fundamental to investigating their biophysical properties. Here, we demonstrate the sizing of EVs using a fluorescence-based flow analyzer with single-molecule sensitivity. Using a dye that selectively partitions into the vesicle's membrane, we show that the fluorescence intensity of a vesicle is proportional to its diameter. We discuss the constraints in sample preparation which are inherent to sizing nanoscale vesicles with a fluorescent membrane dye and propose several guidelines to improve data consistency. After optimizing staining conditions, we were able to measure the size of vesicles in the range ∼35-300 nm, covering the spectrum of EV sizes. Lastly, we developed a method to correct the signal intensity from each vesicle based on its traveling speed inside the microfluidic channel, by operating at a high sampling rate (10 kHz) and measuring the time required for the particle to cross the laser beam. Using this correction, we obtained a threefold greater accuracy in EV sizing, with a precision of ±15-25%.
Congestion control with the fixed cost at the domain border (2010)

CSFQ is designed as an open loop controller to provide fair best effort service, which supervises the bandwidth consumption of pre-flow and has become helpless after P2P flows dominate the traffic of the Internet. Token- Based Congestion Control (TBCC) is based on a closed loop congestion control principle, which restricts the token resource consumed by an end-user and provides fair services with O(1) complexity. As Self-Verifying CSFQ, it is heavy load to police inter-domain traffic for lack of trust. In this paper, Token- Limited Congestion Control (TLCC) is presented, which appends inter-domain congestion control to TBCC. TLCC provides the fixed cost to the inter-domain congestion charging with O(1) complexity. By simulations, it is demonstrated that TLCC can provide stable and fair bandwidth allocation across the domain border.
An Effective EMTR-Based High-Impedance Fault Location Method for Transmission Lines (2020)

This article summarizes the electromagnetic time-reversal (EMTR) technique for fault location, and further numerically validates its effectiveness when the fault impedance is negligible. In addition, a specific EMTR model considering the fault impedance is derived, and the correctness of the model derivation is verified by various calculation methods. Based on this, we found that when the fault impedance is large, the existing EMTR methods might fail to accurately locate the fault. We propose an EMTR method that improves the location effect of high-impedance faults by injecting double-ended signals simultaneously. Theoretical calculations show that this method can achieve an accurate location for high-impedance faults. To further illustrate the effectiveness, the proposed method is compared with the existing EMTR methods and the most commonly used traveling wave-based method using wavelet transform. The simulation results show that the proposed double-ended EMTR method can effectively locate high-impedance faults, and it is more robust against synchronization errors compared with the traveling wave method. In addition, the proposed method does not require the knowledge or a priori guess of the unknown fault impedance.
Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21. (2007)

Using the minimal promoter region of MK to drive the HSV-TK gene and in vivo electroporation to transduce IL-21 DNA into the tumors produced an efficient gene therapy with improved safety. To our knowledge, this is the first report of a combination gene therapy using HSV-TK/GCVand IL-21.
The Human Major Histocompatibility Complex: Lessons from the DNA Sequence (2000)

The entire 3.6-MbpDNA sequence of a human major histocompatibility complex derived from a composite of DNA clones from different haplotypes, was completed in 1999, primarily through the work of four main groups. At that time, it was the longest contiguous human DNA sequence to have been determined. The sequence is of extremely high quality and accuracy. In this review, we discuss how the DNA sequence has facilitated our understanding of the biology and genetics of the major histocompatibility complex. We suggest some ways in which the sequence may be exploited in the future to explore the relationship between the extraordinary polymorphism of the region and its association with both autoimmune and infectious diseases.
A mobile manipulator for installation and removal of aircraft warning spheres on aerial power transmission lines (2003)

A semi-autonomous robot for autonomous installation and removal of aircraft warning spheres on overhead wires of electric power transmission lines is described. Hybrid systems methodology was used to model the basic modes of operation of the robot, which includes both autonomous and tele-operation possibilities. Several sensors and actuators including a custom made gripper are used to accomplish the demanded tasks. The robot was built and tested in real operational situations and proved to be both efficient and robust. It will enable power distribution companies to replace current highly dangerous operations which are normally performed by a human operator placed in a helicopter hovering a few meters away of hotlines. Broader use of this robot in several other common tasks such as line inspection and cleaning, cable changing and object transportation are discussed.
A Multiclass Deep Convolutional Neural Network Classifier for Detection of Common Rice Plant Anomalies (2018)

This study examines the use of deep convolutional neural network in the classification of rice plants according to health status based on images of its leaves. A three-class classifier was implemented representing normal, unhealthy, and snail-infested plants via transfer learning from an AlexNet deep network. The network achieved an accuracy of 91.23%, using stochastic gradient descent with mini batch size of thirty (30) and initial learning rate of 0.0001. Six hundred (600) images of rice plants representing the classes were used in the training. The training and testing dataset-images were captured from rice fields around the district and validated by technicians in the field of agriculture.
[The diagnostic value of In-111 transferrin imaging in protein-losing gastroenteropathy]. (1991)

The diagnostic value of In-111 transferrin abdominal imaging was studied in 17 patients with clinical suspicion of protein-losing gastroenteropathy, compared to that of alpha-1-antitrypsin fecal clearance test. The presence or absence of gastrointestinal protein-loss was finally decided based on the result of alpha-1-antitrypsin fecal clearance test (normal range, less than 13 ml/day) or of protein content measurement on the gastric juice (normal range, less than 71 mg/dl). In-111 transferrin was labeled in vitro. After intravenous administration, serial anterior abdominal images were obtained. All seven patients with a value equal to or more than 20 ml/day on the alpha-1-antitrypsin clearance test and two out of ten patients with a value less than 20 ml/day showed definite intestinal activity demonstrating protein-loss, and the loss-site was estimated by observing the movement of radiotracer within the bowel lumen. The patients with severe protein-loss showed the intestinal activity on the early image. In the patients with milder protein-loss, on the other hand, the activity was noted on the later image. All two patients with positive In-111 transferrin imaging and negative alpha-1-antitrypsin test were associated with protein-losing gastropathy, where a value of alpha-1-antitrypsin clearance was not increased because of denatured alpha-1-antitrypsin by acidic gastric juice and pepsin. These results suggest that In-111 transferrin abdominal imaging can be more useful for the diagnosis of protein-losing gastroenteropathy, because of its capabilities to evaluate the patients with gastropathy as well as to estimate the loss-site.
Three Cases of Fatal Lupus Cardiomyopathy (2015)

Choi, Hyun Chang MD; Jung, Young Ok MD; Jo, Sang-Ho MD; Kim, Hyun Ah MD Author Information
Phase I trial of the targeted alpha-particle nano-generator actinium-225 (225Ac-lintuzumab) (anti-CD33; HuM195) in acute myeloid leukemia (AML). (2011)

6516 Background: Lintuzumab, a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest activity against AML. To increase the antibody’s potency yet avoid nonspecific cytotoxicity seen with β-emitting isotopes, the α-emitter bismuth-213 (213Bi) was conjugated to lintuzumab. Substantial clinical activity was seen in phase I and II trials, but the use of 213Bi is limited by its 46-min half-life. The isotope generator, 225Ac (t½=10 days), yields 4 α-emitting isotopes and can be conjugated to antibodies using DOTA-SCN. 225Ac-labeled immunoconjugates kill in vitro at doses at least 1,000 times lower than 213Bi analogs and prolong survival in mouse xenograft models of several cancers. Methods: We are conducting a first-in-man phase I dose escalation trial to determine the safety, pharmacology, and biological activity of 225Ac-lintuzumab in AML. Results: Twelve patients (median age, 65 yrs; range, 45-80 yrs) with relapsed/refractory AML were treated to date. Patients received a single infusion of 225Ac-lintuzumab at doses of 0.5, 1, 2, 3, or 4 μCi/kg (total dose, 23-390 μCi). No acute toxicities were seen. DLT (myelosuppression lasting >35 days; death due to sepsis) occurred in one patient treated with 3 μCi/kg and in both patients receiving 4 μCi/kg. Extramedullary toxicities were limited to transient grade 2/3 liver function abnormalities. With a median follow-up of 5 mos (range, 1-24 mos), no evidence of radiation nephritis was seen. We analyzed plasma pharmacokinetics by gamma counting at energy windows for 2 daughters of 225Ac, 221Fr and 213Bi. Two-phase elimination kinetics was seen with mean plasma t½-α and t½-β of 1.9 and 35 hours, respectively. These results are similar to other lintuzumab constructs labeled with long-lived isotopes. Peripheral blood blasts were eliminated in 7 of 11evaluable patients. BM blast reductions of >33% were seen in 6 of 10 evaluable patients at 4 weeks, including 2 patients with <5% blasts. Conclusions: This is the first study to show that therapy with a targeted α-particle generator is feasible in humans. 225Ac-lintuzumab is tolerable at doses <4 μCi/kg and has antileukemic activity. Accrual to this trial continues.
The effect of Sr substitution on superconductivity in Hg2(Ba1 ySry)2YCu2O8 : I. A neutron powder diffraction study (2004)

International audience
Seismic response characteristics of seismically isolated bridge considering hardening effect of seismic isolator (2018)

Seismically isolated bridge shows non-linear response both at seismic isolators and columns where intensive earthquake hits the bridge. Such non-linear response characteristics are influenced by the hardening effect of the seismic isolator and over-strength effect of the bridge column. In order to clarify such non-linear behavior of the seismically isolated bridge, seismic response analyses are conducted considering hardening effect of the seismic isolator and uncertainties of non-linear parameters of the seismic isolator and the bridge column using Monte Calro techniques. According to this study, the hardening effect of seismic isolator increases the ductility response of the column and the strength demand of the isolators. Especially the hardening effect of seismic isolator increases the ductility response of the column; furthermore, this effect is more significant where much elongation of natural period by isolator is expected in design. Finally, based on the result of the analyses, the seismic reliability of isolated bridges are evaluated using safety index β.
Fiber Optic Gyroscope Sensors (2017)

The fiber optic gyroscope (FOG), which celebrated its 30th anniversary in 2006, represents the dominant solution in numerous applications of navigation, guidance, and stabilization, particularly in the 0.1 to 10°/hr range. The FOG offers unique advantages over the ring laser gyroscope (RLG), which include: