gebhart/patrepeval huggingface dataset:
CMOS compatible fabrication of 3D photonic crystals by nanoimprint lithography (2015)

Nanoimprinting techniques are an attractive solution for next generation lithography methods for several areas including photonic devices. A variety of potential applications have been demonstrated using nanoimprint lithography (NIL) (e.g. SAW devices, vias and contact layers with dual damascene imprinting process, Bragg structures, patterned media) [1,2]. Nanoimprint lithography is considered for bridging the gap from R and D to high volume manufacturing. In addition, it is capable to adapt to the needs of the fragmented and less standardized photonic market easily. In this work UV-NIL has been selected for the fabrication process of 3D-photonic crystals. It has been shown that UVNIL using a multiple layer approach is well suited to fabricate a 3D woodpile photonic crystal. The necessary alignment accuracies below 100nm were achieved using a simple optical method. In order to obtain sufficient alignment of the stacks to each other, a two stage alignment process is performed: at first proximity alignment is done followed by the Moire´ alignment in soft contact with the substrate. Multiple steps of imprinting, etching, Si deposition and chemical mechanical polishing were implemented to create high quality 3D photonic crystals with up to 5 layers. This work has proven the applicability of nanoimprint lithography in a CMOS compatible process on 3D photonic crystals with alignment accuracy down to 100nm. Optimizing the processes will allow scaling up these structures on full wafers while still meeting the requirements of the designated devices.
X-Ray Net Weight Control of Pharmaceutical Products (2008)

Pharmaceutical manufactures have to ensure that their medication contains precisely the stated quantity of material and active product ingredient (API), so the industry’s quality control standards are very high. The initiative “Process Analytical Technologies ” (PAT), driven by the American food and drug administration (FDA), addresses this task and the improvement of inline inspection systems. To achieve this, a new method has been developed at Bosch Corporate Research for the inline net weight control of pharmaceutical capsules in packaging machines, which shows potential for high accuracy. The method measures the intensity of an x-ray beam that is passed through a capsule. From the attenuation of the beam the exact mass in the sample can be calculated, which makes it an alternative to the conventional process of weighing the sample using a load cell. The x-ray procedure has been automated and is very precise. The thickness variation in the bottom of the capsule is nearly negligible, so the system can be described as a net-weight control system. Reference measurements are taken to compensate for any drift in the method’s sensitivity. As pharmaceutical companies produce large quantities of such capsules, the process has been created with up to 18 parallel x-ray sensors to operate simultaneously to assure short cycle-times. The system is housed in a shielded enclosure, so radiation cannot penetrate to the outside and the x-ray intensity is so low, that it has no effect on the medication, as confirmed by inspections conducted in-house and by independent external specialists. Patients can be confident: All capsules are tested 100 % to ensure they hold the correct mass.
Two perceptions of software maintenance performed by on-site contractor (1984)

Software maintenance is a difficult task under the best of circumstances. Having work performed by an on-site contractor adds an additional layer of complexity to the customer's task. This type of relationship places greater emphasis on formal work procedures and detailed reports of the work in progress. It also promotes the use of performance norms for evaluating contractor performance. These factors are all on the positive side. However, such a relationship also calls for a special awareness of contractor ploys calculated to increase their performance evaluation.
A comparison of high current and low voltage electrical stunning systems on broiler breast rigor development and meat quality (1997)

Experiments were conducted to compare the effects of a high current (HC) stunning system to a low voltage (LV) stunning system on broiler carcass and meat quality. A total of 360 broiler chickens were individually stunned using either 125 mA, 50 Hz, constant AC for 5 s (HC) or using 10.5 V, 500 Hz pulsed DC for 10 s (LV). Birds were individually weighted, killed by conventional neck cut, bled for 150 s, and reweighed to determine blood loss. Breast fillets (Pectoralis major) were removed from the carcass immediately after picking (0 h) or after aging for 24 h in a static ice-water slush. Breast muscle pH was determined at both 0 and 24 h. Raw breast meat color (CIELAB) and cooked breast meat Allo-Kramer shear values were determined on samples held at 2 C for 48 h. The LV stunning treatment significantly increased (P < 0.05) blood loss (4.0 vs 3.7%) and significantly reduced initial muscle pH (6.47 vs 6.67) when compared to the HC stunning treatment. There were no significant differences between the stunning systems for 24 h pH, raw breast color, and Allo-Kramer shear. High current stunning reduced initial blood loss and delayed early rigor development compared to the LV treatment, but appeared to have little effect on final meat quality.
Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome (2014)

Life-threatening infections caused by Staphylococcus aureus, particularly the community-acquired methicillin-resistant strains of S. aureus, continue to pose serious problems. Greater virulence and increased pathogenicity of certain S. aureus strains are attributed to higher prevalence of exotoxins. Of these exotoxins, the superantigens (SAg) are likely most pathogenic because of their ability to rapidly and robustly activate the T cells even in extremely small quantities. Therefore, countering SAg-mediated T cell activation using T regulatory cells (Tregs) might be beneficial in diseases such as toxic shock syndrome (TSS). As the normal numbers of endogenous Tregs in a typical host are insufficient, we hypothesized that increasing the Treg numbers by administration of IL-2/anti-IL-2 Ab immune complexes (IL2C) or by adoptive transfer of ex vivo expanded Tregs might be more effective in countering SAg-mediated immune activation. HLA-DR3 transgenic mice that closely recapitulate human TSS were treated with IL2C to increase endogenous Tregs or received ex vivo expanded Tregs. Subsequently, they were challenged with SAg to induce TSS. Analyses of various parameters reflective of TSS (serum cytokine/chemokine levels, multiple organ pathology, and SAg-induced peripheral T cell expansion) indicated that increasing the Tregs failed to mitigate TSS. On the contrary, serum IFN-γ levels were increased in IL2C-treated mice. Exploration into the reasons behind the lack of protective effect of Tregs revealed IL-17 and IFN-γ-dependent loss of Tregs during TSS. In addition, significant upregulation of glucocorticoid-induced TNFR family-related receptor on conventional T cells during TSS could render them resistant to Treg-mediated suppression, contributing to failure of Treg-mediated immune regulation.
Angular, temperature, and impurity effects on secondary electron emission from Ni(110) (2018)

The secondary electron emission from a temperature-controlled Ni(110) sample was examined for 50–1500 eV electrons impacting at 0°–35°, 50°, and 78°. Measurements showed a non-cosine dependence on an electron incidence angle: the yield has a maximum at 0°, minima at ±12°, and increases at larger angles up to 35°. This trend in angular dependence is characteristic of single crystal materials and is due to increased secondary electron generation when primary electrons are directed along a close-packed direction. For example, compared to polycrystalline nickel, the yield for Ni(110) from primary electrons at 0° (i.e., along the [110] direction) is up to 36% larger. Additionally, secondary electron yields are highly sensitive to incident electron energy (most notably between 0 and 500 eV) and to the presence of adsorbed carbon monoxide [with an up to 25% decrease compared to clean Ni(110)]. However, yields are independent of sample temperature between 300 and 600 K and of exposure to deuterium ions leading to formation of subsurface hydrogen. These results reaffirm the unique secondary electron emission properties of single crystals materials and highlight the importance of crystal orientation. Results are important for plasma-enhanced chemistry applications that utilize Ni(110) catalysts, since larger secondary electron emission may facilitate reactions of adsorbed species.
Mobility and other predictors of hospitalization for urinary tract infection: a retrospective cohort study (2008)

Maintaining or improving mobility (walking, transferring between positions, or moving in bed) was associated with a lower risk of hospitalization for UTI. A physician visit at the time of admission to the skilled nursing facility also reduced the risk of hospitalization for UTI.
Evaluation of the ability of Acinetobacter baumannii to form biofilms on six different biomedical relevant surfaces (2016)

In the hospital environment, Acinetobacter baumannii is one of the most persistent and difficult to control opportunistic pathogens. The persistence of A. baumannii is due, in part, to its ability to colonize surfaces and form biofilms. This study demonstrates that A. baumannii can form biofilms on a variety of different surfaces and develops substantial biofilms on polycarbonate - a thermoplastic material that is often used in the construction of medical devices. The findings highlight the need to further study the in vitro compatibility of medical materials that could be colonized by A. baumannii and allow it to persist in hospital settings.
PCR-ELISAs for the Detection of Campylobacter jejuni and Campylobacter coli in Poultry Samples (2001)

Campylobacter species, primarily Campylobacter jejuni and Campylobacter coli, are regarded as a major cause of human gastrointestinal disease, commonly acquired by eating undercooked chicken. We describe a PCR-ELISA for the detection of Campylobacter species and the discrimination of C. jejuni and C. coli in poultry samples. The PCR assay targets the 16S/23S ribosomal RNA intergenic spacer region of Campylobacter species with DNA oligonucleotide probes designed for the specific detection of C. jejuni, C. coli, and Campylobacter species immobilized on Nucleo-Link wells and hybridized to PCR products modified with a 5' biotin moiety. The limit of detection of the PCR-ELISA was 100-300 fg (40-120 bacterial cells) for C. jejuni and C. coli with their respective species-specific oligonucleotide probes and 10 fg (4 bacterial cells) with the Campylobacter genus-specific probe. Testing of poultry samples, which were presumptive positive for Campylobacter following culture on the Malthus V analyzer, with the PCR-ELISA determined Campylobacter to be present in 100% of samples (n = 40) with mixed cultures of C. jejuni/C. coli in 55%. The PCR-ELISA when combined with culture pre-enrichment is able to detect the presence of Campylobacter and definitively identify C. jejuni and C. coli in culture-enriched poultry meat samples.
Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1) (2022)

Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO<sub>2peak</sub>) in BRCA1/2 mutation carriers whose risk of developing BC is high. We used cross-sectional data from 68 BRCA1/2 germline mutation carrying women participating in the randomized, prospective, controlled clinical study LIBRE-1. Assessments included cardiopulmonary exercise testing, medical and lifestyle history plus socioeconomic status. Additionally, the participants completed a psychological questionnaire regarding their attitude, subjective norms, perceived behavior control and intention towards PA. A multivariate logistic regression model was used to identify predictors for participants reaching their age- and sex-adjusted VO<sub>2peak</sub> reference values. 22 participants (median age: 40 years, interquartile range (IQR) 33-46) were cancer-unaffected and 46 cancer-affected (median age: 44 years, IQR 35-50). The strongest predictor for reaching the reference VO<sub>2peak</sub> value was attitude towards PA (Odds Ratio 3.0; 95% Confidence Interval 1.3-8.4; p = 0.021). None of the other predictors showed a significant association. A positive attitude towards PA seems to be associated with VO<sub>2peak</sub>, which should be considered in developing therapeutic and preventive strategies.Trial registrations: NCT02087592; DRKS00005736.
Potential errors in the application of mixture theory to multifrequency bioelectrical impedance analysis (1998)

Potential errors in the application of mixture theory to the analysis of multiple-frequency bioelectrical impedance data for the determination of body fluid volumes are assessed. Potential sources of error include: conductive length; tissue fluid resistivity; body density; weight and technical errors of measurement. Inclusion of inaccurate estimates of body density and weight introduce errors of typically < +/- 3% but incorrect assumptions regarding conductive length or fluid resistivities may each incur errors of up to 20%.
The talent system (2003)

We present the architecture and data model for TEXTRACT, a document analysis framework for text analysis components. The framework and components have been deployed in research and industrial environments for text analysis and text mining tasks.
Targeted siRNA delivery to myeloid precursor cells (2011)

RNA interference (RNAi) provides a new way to target „undruggable sides“ of the body for several kind of diseases, e.g. leukaemia. Several fusion proteins are indispensable for the maintenance of leukaemic growth both in vitro and in vivo.
Free Deformation of the Initial Solid Layer of Some Non-ferrous Alloys (1993)

In order to elucidate the effect of deformation of initial solidified layer on surface defects of continuously cast slabs, the deformation behavior of freely solidifying disc was observed with several non-ferrous metals and their alloys by the droplet method. The following results were obtained:(1) After solidification and cooling to room temperature, the shape of the shell bottom of all the metals and alloys tested became parabolic.(2) Deformation of pure metals was positive, i.e. convex toward chill and was attributed to thermal contraction after solidification. A model for the prediction of deformation of pure metals was proposed and a fair agreement with experimental results was obtained.(3) Direction of deformation of alloys was either positive or negative, sometimes very large near eutectic, depending on the composition. This is because many alloys solidify to form supersaturated solid solution, from which a second phase precipitates causing expansion or contraction, depending on the difference of molar specific volumes of the two phases.
The S. mansoni glycoprotein ω‐1 induces Foxp3 expression in NOD mouse CD4+ T cells (2011)

Immunization with Schistosoma mansoni soluble antigen preparations protects non-obese diabetic (NOD) mice against the development of type 1 diabetes. These preparations have long been known to induce Th2 responses in vitro and in vivo. Recently, two separate groups have reported that ω-1, a well-characterized glycoprotein in S. mansoni soluble egg antigens (SEA), which with IL-4 inducing principle of S. mansoni eggs (IPSE/α-1) is one of the two major glycoproteins secreted by live eggs, is a major SEA component responsible for this effect. We found that ω-1 induces Foxp3 as well as IL-4 expression when injected in vivo. We confirmed that ω-1 conditions DCs to drive Th2 responses and further demonstrated that ω-1 induces Foxp3(+) T cells from NOD mouse naïve T cells. In contrast, IPSE/α-1 did not drive Foxp3 responses. The in vitro development of Foxp3-expressing T cells by ω-1 was TGF-β- and retinoic acid-dependent. Our work, therefore, identifies ω-1 as an important factor for the induction of Foxp3(+) T cells by SEA in NOD mice.
Pressure and tendon strain in the sixth extensor compartment of the wrist during simulated provocative maneuvers for diagnosing extensor carpi ulnaris tendinitis. (2015)

Various provocative maneuvers for diagnosing extensor carpi ulnaris (ECU) tendinitis have been reported; however, it remains unclear which maneuver is the most sensitive to detect ECU tendinitis. To clarify this, we investigated and compared the extratendinous pressure and ECU tendon strain in the sixth extensor compartment of the wrist during various provocative maneuvers for diagnosing ECU tendinitis.Nine upper extremities from nine fresh-frozen cadavers were examined. We investigated extratendinous pressure in the ECU fibro-osseous tunnel of the distal ulna and ECU tendon strain during eight forearm positions-neutral rotation, pronation, supination, pronation with wrist flexion, supination with wrist flexion, supination with wrist extension, both hand and forearm supination, and supination with ECU full loading-to simulate provocative maneuvers reported to detect ECU tendinitis.Pressure was significantly higher during both hand and forearm supination (carpal supination test) and during supination with wrist extension (prayer's hand supination test) than during neutral rotation. The pressure during the carpal supination test was 3 times higher than that during the prayer's hand supination test and 27 times higher than that during the neutral position. Strain was significantly higher during the carpal supination test and during supination with ECU full loading (the ECU synergy test) than during other maneuvers.Both pressure and tendon strain increased most notably during the carpal supination test compared to the other maneuvers, which suggests that the carpal supination test is the most sensitive for the detection of ECU tendinitis.
Electronic steerable MEMS antennas (2006)

Recent advances in the technology of radiofrequency (RF) circuits, such as RF-microelectromechanical systems (MEMS) make it possible to practically implement electronically reconfigurable antenna arrays paving the way to innovative communication systems including applications such as next generation mobile communications, radar applications, remote sensing and imaging. This paper reviews the basic implementations of such antenna systems, namely phased arrays and reflectarrays, as well as the algorithms allowing for beam shaping, beam steering, null placing etc., as well as the typical RF-MEMS circuitry for both amplitude and phase control.
Supplementary Data from Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer (2023)

&lt;p&gt;Supplementary Dataset Table 1&lt;/p&gt;
Morphological Evolution of ZnO Thin Films Deposited by Reactive Sputtering (2003)

The morphological evolution of ZnO thin films deposited by magnetron sputtering has been investigated on two types of substrates, (111) textured Pt and (100) Si possessing a native oxide. The ZnO films are oriented with the c-axis [0001] normal to the substrate and possess varying degrees of crystallinity. The films have a columnar structure with column diameters in the range of 40−300 nm. As observed by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and X-ray diffraction, the film microstructure is strongly dependent on substrate temperature during deposition in the range from near room temperature up to 700 °C and is also dependent on substrate type. A textured film of platinum promotes nucleation thereby improving the crystallinity and texture of sputtered ZnO films. A mechanism for morphological evolution of the films via surface diffusion is proposed based on atom mobilities.
Polymorphic expression of defensins in neutrophils from outbred rats (1990)

We isolated and characterized a rat neutrophil defensin, RatNP-2, that differs from the previously described defensin RatNP-1 by containing Ser-7 in place of Arg-7. Although the resulting charge difference rendered RatNP-2 easily distinguishable from RatNP-1 on polyacrylamide gel electrophoresis gels, the two defensins exhibited very similar antimicrobial efficacies against Salmonella typhimurium, Staphylococcus aureus, and Candida albicans. The polymorphonuclear leukocytes of Sprague-Dawley rats obtained from one of two breeders also showed a marked polymorphism for defensin RatNP-4. This defensin was absent in two of seven animals and present in 1x or 2x relative amounts in the others. These observations indicate that a striking degree of defensin polymorphism exists in the polymorphonuclear leukocytes of outbred rodents.
Physical properties of antitumor glutaminase-asparaginase from Pseudomonas 7A. (1976)

Glutaminase-asparaginase from Pseudomonas 7A appears to have four subunits with a molecular weight of 36,000 +/- 500 by sedimentation equilibrium in 5.9 M guanidine HCl and 34,000 by amino acid analysis. Analytic sedimentation equilibrium of the native enzyme showed a molecular weight of 140,000 +/- 3,300 with no signs of association or dissociation. Moving boundary and zone sedimentation in buffer showed normal behavior with sedimentation coefficients of 7.92 and 7.75 S, respectively. In contrast, the enzyme appeared to polymerize during zone sedimentation when the initial protein concentration was greater than 1 mg/ml and the buffer contained asparagine, glutamine, or 5-diazo-4-oxonorvaline. An extension of our method for active enzyme sedimentation is described which utilizes the changes in absorption during hydrolysis of asparagine by low concentrations of enzyme. Polymerization was not seen under these conditions.
Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis (2011)

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population. Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin = 2.96 ± 0.13 g/dL, C-reactive protein [CRP] = 6.71 ± 1.34 μg/dL, and beta-2-microglobulin = 1.68 ± 0.10 μg/L) were evaluated and had BIA over 24 weeks. Results. Weight increased by 3.02 ± 0.81 kg (5.5%; P = 0.007) at week 4 and by 8.59 ± 0.97 kg (15.6%; P < 0.0001) at week 24. Repletion of body mass was primarily fat, which increased by 2.09 ± 0.52 kg at week 4 and 5.05 ± 0.56 kg at week 24 (P = 0.004 and P < 0.0001 versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to 3.65 ± 0.14 g/dL by week 4 (P < 0.001) and slowly increased thereafter. CRP levels declined by ∼50% at each interval visit. Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.
Executive Commentary (1994)

The article presents a commentary on the paper “The Leadership Mystique,” by Manfred F. R. Kets de Vries. The author believes that most leaders do a reasonable job of creating environments in which people can perform. He notes that many in leadership positions could benefit from the exploration of their impact on an organization's culture and performance. The author points out that the research failed to acknowledge potential differences between men and women in leadership roles. He explains that some organizational dynamics may be gender specific.