gebhart/patrepeval huggingface dataset:
Narrowband IoT Service Provision to 5G User Equipment via a Satellite Component (2017)

Today an estimated 15 billion of connected objects communicate with each other''s. These connected objects that compose the Internet of Things (IoT) are expected to extend to 50 or 80 billion worldwide by 2020. Bringing wide-area connectivity for the IoT using satellite technology is therefore an attractive solution to complement terrestrial networks, allowing densification and coverage extension in remote areas. This paper deals with seamless integration of satellites and high altitude platforms (HAPS) into 5G networks. It describes the necessary modifications to operate on 5G systems in order to take satellite and HAPS specifics into account. Link budget calculations and system dimensioning, including channel modeling, are provided to determine the required satellite and HAPS performance as well as to estimate the number of served users per km <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes (2019)

This protocol demonstrates a method for electrochemical roughening of thin-film platinum electrodes without preferential dissolution at grain boundaries of the metal. Using this method, a crack free, thin-film macroelectrode surface with up to 40 times increase in active surface area was obtained. The roughening is easy to do in a standard electrochemical characterization laboratory and incudes the application of voltage pulses followed by extended application of a reductive voltage in a perchloric acid solution. The protocol includes the chemical and electrochemical preparation of both a macroscale (1.2 mm diameter) and microscale (20 µm diameter) platinum disc electrode surface, roughening the electrode surface and characterizing the effects of surface roughening on electrode active surface area. This electrochemical characterization includes cyclic voltammetry and impedance spectroscopy and is demonstrated for both the macroelectrodes and the microelectrodes. Roughening increases electrode active surface area, decreases electrode impedance, increases platinum charge injection limits to those of titanium nitride electrodes of same geometry and improves substrates for adhesion of electrochemically deposited films.
A Fully Automated Post-Surgical Brain Tumor Segmentation Model for Radiation Treatment Planning and Longitudinal Tracking (2023)

Glioblastoma (GBM) has a poor survival rate even with aggressive surgery, concomitant radiation therapy (RT), and adjuvant chemotherapy. Standard-of-care RT involves irradiating a lower dose to the hyperintense lesion in T2-weighted fluid-attenuated inversion recovery MRI (T2w/FLAIR) and a higher dose to the enhancing tumor on contrast-enhanced, T1-weighted MRI (CE-T1w). While there have been several attempts to segment pre-surgical brain tumors, there have been minimal efforts to segment post-surgical tumors, which are complicated by a resection cavity and postoperative blood products, and tools are needed to assist physicians in generating treatment contours and assessing treated patients on follow up. This report is one of the first to train and test multiple deep learning models for the purpose of post-surgical brain tumor segmentation for RT planning and longitudinal tracking. Post-surgical FLAIR and CE-T1w MRIs, as well as their corresponding RT targets (GTV1 and GTV2, respectively) from 225 GBM patients treated with standard RT were trained on multiple deep learning models including: Unet, ResUnet, Swin-Unet, 3D Unet, and Swin-UNETR. These models were tested on an independent dataset of 30 GBM patients with the Dice metric used to evaluate segmentation accuracy. Finally, the best-performing segmentation model was integrated into our longitudinal tracking web application to assign automated structured reporting scores using change in percent cutoffs of lesion volume. The 3D Unet was our best-performing model with mean Dice scores of 0.72 for GTV1 and 0.73 for GTV2 with a standard deviation of 0.17 for both in the test dataset. We have successfully developed a lightweight post-surgical segmentation model for RT planning and longitudinal tracking.
A PopZ‐linked apical recruitment assay for studying protein–protein interactions in the bacterial cell envelope (2019)

Summary Most bacteria are surrounded by a complex cell envelope. As with many biological processes, studies of envelope assembly have benefited from cell‐based assays for detecting protein–protein interactions. These assays use simple readouts and lack a protein purification requirement, making them ideal for early stage investigations. The most widely used two‐hybrid interaction assay for proteins involved in envelope biogenesis is based on the reconstitution of adenylate cyclase activity from a split enzyme. Because adenylate cyclase is only functional in the cytoplasm, both protein fusions used in the assay must have a terminus located in this compartment. However, many envelope assembly factors are wholly extracytoplasmic. Detecting interactions involving such proteins using two‐hybrid systems has therefore been problematic. To address this issue, we developed a cytological assay in Escherichia coli based on PopZ from Caulobacter crescentus . Here, we demonstrate the utility of this PopZ‐Linked Apical Recruitment (POLAR) method for detecting interactions between proteins located in different cellular compartments. Additionally, we report that recruitment of an active peptidoglycan synthase to the cell pole is detrimental for E. coli and that interactions between proteins in the inner and outer membranes of the Gram‐negative envelope may provide a mechanism for recruiting protein complexes to subpolar sites.
Phase III MIRASOL (GOG 3045/ENGOT-ov55) study: Initial report of mirvetuximab soravtansine vs. investigator's choice of chemotherapy in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression. (2023)

LBA5507 Background: Mirvetuximab soravtansine (MIRV), an antibody drug conjugate targeting FRα, demonstrated clinically meaningful antitumor activity in a single arm trial reported previously (Matulonis, JCO 2023). MIRASOL is a randomized phase 3 trial to confirm the efficacy of MIRV vs standard-of-care chemotherapy in patients (pts) with PROC. Methods: 453 PROC pts with high FRα expression (Roche FOLR1 Assay) with 1-3 priors were randomized 1:1 to MIRV 6 mg/kg, adjusted ideal body weight, Day 1 of a 21-day cycle or IC: paclitaxel, pegylated liposomal doxorubicin, or topotecan. The primary efficacy endpoint was progression-free survival (PFS) by investigator (INV) with key secondary endpoints ORR, overall survival (OS), and patient-reported outcomes in hierarchical order; other endpoints included safety and tolerability. Blinded independent central review (BICR) for PFS and ORR were sensitivity analyses. Results: With a data cutoff of March 6, 2023, 227 pts were randomized to the MIRV arm; 226 to the IC arm. Median follow-up was 13.1 months. Baseline characteristics were well balanced across arms; 14% of pts had one, 39% two, and 47% three prior lines of therapy; 62% received prior bev; and 55% received prior PARPi therapy. The study met its primary and key secondary endpoints with statistically significant results in PFS (INV), ORR (INV), and OS (Table). In the bev-pretreated subset (n=281), PFS HR was 0.64 (0.492, 0.842) and OS HR was 0.74 (0.535, 1.036); in the bev-naïve subset (n=172), PFS HR was 0.66 (0.459, 0.942) and OS HR was 0.51 (0.306, 0.860). The adverse event (AE) profile of MIRV was consistent with prior reports: predominantly low-grade ocular (MIRV vs IC all grade 56% vs 9%; grade 3+ 14% vs 0%) and gastrointestinal events (MIRV vs IC all grade 70% vs 66%; grade 3+ 13% vs 15%). Compared with IC, MIRV was associated with lower rates of grade 3+ treatment-emergent AEs (42% vs 54%), serious AEs (24% vs 33%), and discontinuations due to TEAEs (9% vs 16%). Fourteen percent of pts on the MIRV arm remained on study drug vs 3% on the IC arm. Conclusion: MIRV is the first treatment to demonstrate a PFS and OS benefit in PROC compared to IC. The efficacy data, along with the well-characterized safety profile, position MIRV as a new, standard of care for pts with FRα positive PROC. Clinical trial information: NCT04209855 .[Table: see text]
Call for papers: Optical Ethernet (2002)

The editors of the Journal of Optical Networking are soliciting papers for a special issue on "Optical Ethernet in a Carrier-Type Environment." The submission deadline has been extended to May 1, 2002
Experimental and Theoretical Analysis of Cabled Beams (2015)

Peer Reviewed
Antagonistic effect of interferon-gamma on tat-induced transactivation of HIV long terminal repeat. (1992)

Interferon-gamma (IFN-gamma) has been shown to inhibit human immunodeficiency virus (HIV) replication in macrophages. However, the site of its effect on the HIV infectious cycle is unknown. We show here that IFN-gamma inhibits the transactivation of HIV long terminal repeat (LTR) during viral infection and that it antagonizes tat effect in HT4LacZ-1 cells. HT4LacZ-1 is an indicator CD4+ HeLa cell line for HIV infectivity, because it harbors a HIV LTR-LacZ gene susceptible to transactivation by tat. It was used in combination with a computer-assisted image analyzer to quantify: (i) the number of transactivated foci following HIV infection, (ii) their individual level of transactivation, and (iii) the fusion potency of infected cells. IFN-gamma induced a 75% decrease of the number of transactivated foci following infection of HT4LacZ-1 cells by HIV. The remaining 25% foci still susceptible to transactivation were transactivated at a lower level than in control cultures, and the fusion potency of infected cells was strongly decreased. IFN-gamma acted after HIV entry into the cell and independently of reverse transcription. IFN-gamma antagonized tat-induced LTR transactivation: it inhibited transactivation of HT4LacZ-1 cells when tat was provided either from a SV40-based expression vector of tat or by polyethylene glycol-induced cell fusion with HeLa-tat-III cells. These results suggest that IFN-gamma affects the expression or the activity of cellular factors interacting with tat and that the high level of IFN-gamma production associated with HIV infection plays a role in the establishment of HIV latency.
COORDINATIVE ADDITION REACTIONS OF TERTIARY PHOSPHINES TO BISPHOSPHINE- AND BISPHOSPHITEPALLADIUM(O) COMPLEXES. FORMATION OF FOURCOORDINATE PALLADIUM(O) SPECIES WITH C3v-SYMMETRY (1984)

Abstract Low-temperature 31P-NMR studies of the coordinative additions of tertiary phosphines, Ph2MeP and Et3P, to twocoordinate palladium(O) complexes, (Ph3P)2Pd(O) and [(PhO)3P]2pd(O), in toluene-d8 show the formation of fourcoordinate complexes with C3v-symmetry, (Ph2MeP)3(Ph3P)Pd and (Et3P)[(PhO)3P]3Pd, respectively.
Rheology of a New Sulfonic Associative Polymer in Porous Media (2011)

Summary For hydrophobically associative polymers, incorporating a small fraction of hydrophobic monomer into a hydrolyzed polyacrylamide (HPAM) polymer can promote intermolecular associations and thereby enhance viscosities and resistance factors. In this paper, we investigate the behavior of a new associative polymer in porous media. The tetra-polymer has low hydrophobic-monomer content and a molecular weight (Mw) of 12–17 million g/mol. Total anionic content is 15–25 mol%, including a few percent of a sulfonic monomer. This polymer is compared with a conventional HPAM with 18–20 million g/mol Mw and 35–40% anionic content. Rheological properties (viscosity vs. concentration; and shear rate and elastic and loss moduli vs. frequency) were similar for the two polymers [in a 2.52% total dissolved solids (TDS) brine at 25 °C]. For both polymers in cores with permeabilities from 300 to 13,000 md, no face plugging or internal-filter-cake formation was observed, and resistance factors correlated well using the capillary-bundle parameter. For the HPAM polymer in these cores, low-flux resistance factors were consistent with low-shear-rate viscosities. In contrast, over the same permeability range, the associative polymer provided low-flux resistance factors that were two to three times the values expected from viscosities. Moderate shear degradation did not eliminate this effect—nor did flow through a few feet of porous rock. Propagation experiments in long cores (up to 157 cm) suggest that the unexpectedly high resistance factors could propagate deep into a reservoir—thereby providing enhanced displacement compared with conventional HPAM polymers. Compared with HPAM, the new polymer shows a significantly higher level of shear thinning at low fluxes and a lower degree of shear thickening at high fluxes.
Facsimile (fax) technology. (1991)

Fax technology is the transmission of text and graphic data between two locations via telephone lines. The advantages of this technology include the speed with which a document can be sent anywhere in the world and the decreased cost versus traditional courier and Telex services. Several different types of machines exist, but standard operating parameters are set by the Consultative Committee for International Telephone and Telegraph (CCITT). There are four categories of machines, called Groups, which aid in classifying the various fax units. Group 3 machines are the most common comprising about 75% of the market. Standard features vary between and within groups, depending on the manufacturer and model. Features such as polling, document broadcasting, security levels, and computer linkage are discussed. The healthcare industry has been slow to adopt fax technology. Applications in hospital pharmacy are the main focus of attention of some hospital administrators and directors of pharmacy. A few studies have shown decreased medication order turnaround time after implementation of a fax-based pharmacy order system. However, problems such as order clarity and legibility, elevated nursing expectations and increased use of paper can decrease its usefulness. Overall, facsimile technology will find a place in the healthcare arena and may become an integral part of the modern pharmacy department.
Diboronate Fluorophore for the Measurement of l-Glucose and Other Carbohydrates and Its Interaction with Albumin (2022)

l-Glucose has recently been investigated as an artificial sweetener, but no facile method is established for the measurement of l-glucose. The commercial probe Eversense employs a fluorescent diboronate in a small device for the optical monitoring of d-glucose in people with diabetes. Being achiral, the Eversense probe should be able to detect l-glucose as well as native d-glucose, but the probe is designed for fixation under the skin, and our attempts to use the probe at laboratory conditions failed, as the probe was resetting when moved between compartments. We thus designed a water-soluble anthracene diboronate <b>8</b> similar to the fluorophore used in Eversense and found <b>8</b> to respond well to l-glucose and other carbohydrates and artificial sweeteners, thus enabling measurements of l-glucose with the limit of quantification of 12 μM. Notably, the fluorescent signal of diboronate <b>8</b> was largely quenched in buffers with the physiological concentration of albumin (0.5 mM), so the given analytical method would need more optimization to be useful for measuring l-glucose and other carbohydrates in blood samples. We suspect that other diboronate fluorophores from the literature may be similarly quenched if applied in the presence of albumin.
Borrego Mountain Earthquake of April 8, 1968 (1970)

The strongest earthquake to hit California in more than 15 yr struck the western edge of the Imperial Valley near Borrego Mountain at 6:29 p.m. (PST), Monday, April 8, 1968. Damage was generally light and there were no serious injuries, chiefly because the shock occurred within one of the least developed and least-populated sections of southern California.
Inherent Differences in Nasal and Tracheal Ciliary Function in Response to Pseudomonas aeruginosa Challenge (2011)

Using primary murine nasal and tracheal airway cultures we show inherent differences in cilia function and increased susceptibility of the upper airway to attachment by Pseudomonas. Understanding the differences between upper and subglottic airway mucociliary clearance should lead to novel approaches in the management of upper airway infection.
Synthesis and Characterization of Poly(ethylene glycol) Dimethacrylate Hydrogels (2005)

Abstract Facile synthesis and detailed characterization of photo‐polymerizable and biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) and their hydrogels are described. Combined analyses of 1 H NMR and MALDI‐TOF MS confirmed the formation of prepolymers of high purity and narrow mass distribution (PD &lt; 1.02). A systematic investigation into the structure and mechanical properties of PEGDM hydrogels was performed to characterize the relationships between the network structure and gel properties. Small‐angle neutron scattering was used to characterize the structural features of hydrogels with respect to their semidilute solution precursors. A well‐defined structural length scale (correlation length) manifested as a maximum in the scattering intensity was observed for hydrogels derived from high molecular mass PEGDMs and/or high oligomer mass fractions. Hydrogels derived from lower molecular mass PEGDMs and/or low oligomer mass fractions exhibited multiple correlation lengths suggesting the formation of inhomogeneous gel structures. The shear moduli, determined from uniaxial compression measurement, showed that the gel structures correlate well with the gel mechanical properties.
Taxonomic Status ofIxodes didelphidis(Acari: Ixodidae) (2002)

Ixodes didelphilis Fonseca & Aragão was described in Brazil in 1952 as a new tick species that differed from Ixodes loricatus Neumann by the spiracular plate pattern. We have reared four tick colonies from different geographic areas in the laboratory that were started from single engorged females originally identified as I. didelphidis (BMG, colony ) and I. Iocicatus (CSP, PSP, and TRJ colonies). We analyzed the spiracular plate morphology of F1 adult ticks from each tick colony, compared their biological 11th, and performed a molecular analysis of the second internal transcribed rDNA spacer (ITS2) to test the validity of the species I. didelphidis. The spiracular plate analysis of laboratory F1 adult ticks yielded single females from the four colonies showed variations that invalidate morphological parameters for differentiation of loricatus and I. didelphidis. Biological data of the BMC, CSP, and TRJ colonies were similar. The biology ofthe PSP colony was not evaluated. The ITS2 sequence variations observed between the tick colonies ranged from 1.3 to 4.9%, and the similarity tree constructed by the neighbor-joining method with nucleotide distances showerl that the distances between the samples were similar to what is expected for intraspecific variations found in other ticks species. The morphological and biological results, in conjunction with the ITS2 analysis, supported the conspecificity I. loricatus and I. didelphidis.
Interface inter-atomic electron-transition induced photon emission in contact-electrification (2021)

Contact electrification (CE) (or triboelectrification) is the phenomena where charges are produced through physical contact between two materials. Here we report the atomic featured photon emission spectra during CE between two solid materials. Photon emission provides the evidence that electron transfer takes place at the interface from an atom in one material to another atom in the other material during CE. This process is the contact electrification induced interface photon emission spectroscopy (CEIIPES). It naturally paves a way to a spectroscopy corresponding to the CE at an interface, which might impact our understanding of the interaction between solids, liquids, and gases. The physics presented here could be expanded to Auger electron excitation, x-ray emission, and electron emission in CE for general cases, which remain to be explored. This could lead to a general field that may be termed as contact electrification induced interface spectroscopy (CEIIS).
Evaluation of the Comparability and Repeatability of Four Wavefront Aberrometers (2010)

Total ocular and corneal aberrations are not comparable when measured with different aberrometers. Hartmann-Shack aberrometers showed the best repeatability for total ocular aberrations and iTrace for corneal aberrations. It would be worthwhile in the future to evaluate aberrometers in patients with more aberrant eyes.
Cloning and Sequence Analysis of the Poly(3-Hydroxyalkanoic Acia)-Synthesis Genes of Pseudomonas acidophila (1998)

Pseudomonas acidophila can grow with CO2 as a sole carbon source by the possession of a recombinant plasmid that clones genes that confer chemolithoautotrophic growth ability derived from the H2-oxidizing bacterium Alcaligenes hydrogenophilus. H2-oxidizing bacteria produce poly(3-hydroxybutyric acid) (PHB) from CO2, but recombinant P. acidophila can produce the more useful biopolymer poly(3-hydroxyalkanoic acid) (PHA). In this study, the pha genes of P. acidophila were cloned and a sequence analysis was carried out. A gene library was constructed using the cosmid vector pVK102. A recombinant cosmid carrying the pha genes was selected by the complementation of a PHB-negative mutant of Alcaligenes eutrophus H16. The resulting recombinant cosmid pIK7 contained a 14.8-kb DNA insert. Subcloning was done. and the recombinant plasmid pEH74 was selected by hybridization with the A. eutrophus H16 pha genes. Escherichia coli possessing pEH74 produced PHB, indicating that pEH74 contained the pha genes of P. acidophila. The nucleotide sequences of the PHA-synthesis genes phaA (beta-ketothiolase), phaB (acetoacetyl-CoA reductase), and phaC (PHA synthase) in pEH74 were determined. The homologies of phaA, phaB, and phaC between P. acidophila and A. eutrophus H16 were 64.7, 76.1 and 56.6%, respectively.
Quantitative evaluation of information system security (1998)

This paper presents a method for the evaluation of the security of information systems. First, we outline briefly the overall guidelines of the method: specification of the security policy, description of the vulnerabilities of the target organization, and a quantitative evaluation approach based on the privilege graph model. Then, the paper presents how the method applies to the description of the security requirements of a real organization: a medium-size bank agency. To illustrate the interest of the security measures, this example is used as a basis for applying the evaluation methodology taking into account some vulnerabilities of the bank agency.
Non-coding RNAs and functional RNA elements in <i>Thermus thermophilus</i><i> </i> (2023)

To complete the ThermusQ database, small non-coding RNAs (ncRNAs) and functional RNA elements found in Thermus thermophilus were summarized with annotations. The well-known three ncRNAs, M1 RNA, tmRNA and SRP RNA, were annotated as ttj8_nc001 to ttj8_nc003, and 10 novel RNAs were annotated as ttj8_nc004 to ttj8_nc013. Antisense RNAs for some ORFs were annotated as ttj8_EST00001 to ttj8_EST00006. In addition, a set of conserved sequences found in T. thermophilus HB27 were also described.
Adjustable filmstrips and skims as abstractions for a digital video library (2003)

Filmstrips and video skims are two presentation schemes for abstracting information in a digital video segment. Filmstrips present information all at once in a static form, while video skims are played and disclose information temporally. The paper discusses the evolution of the filmstrip and skim interfaces in the Informedia Digital Video Library. Filmstrips are commonly deployed as interfaces for video and image libraries, but we found initial Informedia filmstrips and skims received little use. We discuss the interface considerations motivating the redesign of filmstrips and skims to adjust their presentations dynamically based on user context and preference.