gebhart/patrepeval huggingface dataset:
Abstract 13621: Genetic and Pharmacological Induction of Endothelial Sirt3 After Onset of Hypertension Rescues Endothelial Function (2022)

Endothelial dysfunction plays critical role in the pathogenesis of hypertension and atherosclerosis. These pathological conditions are main risk factors for cardiovascular disease killing 700,000 people every year in US alone. We discovered a new control point with the potential to address this problem. We have shown that Sirt3 level is reduced in essential hypertension and endothelial Sirt3 overexpression attenuates endothelial dysfunction and hypertension. We proposed induction of endothelial Sirt3 after onset of hypertension to rescue endothelial function and reduce hypertension. To test the hypothesis, we used genetic- and pharmacological Sirt3 activation. To genetically induce the expression of endothelial Sirt3 we used Sirt3 flox/flox mice crossed with VeCad-Cre mice treated with low dose of 4-hydroxytamoxifen (4HOT, i.p. 0.3 mg/20 g daily, 5 days) which does not have off-target cardiovascular effects. Mice underwent telemetry placement and ten days later received 4-week osmotic pumps containing vehicle (saline) or angiotensin II (0.7 mg/kg/day). 14-days later half of mice received 4HOT to induce endothelial Sirt3 overexpression. Treatment of mice with 4HOT after onset of hypertension slightly reduced blood pressure but most importantly rescued endothelial-dependent relaxation, normalized mitochondrial O 2 . - and restored endothelial nitric oxide. Second, we tested if pharmacological induction of Sirt3 by hexafluoro (i.p. 8 mg/kg, 4 days) after onset of angiotensin II-induced hypertension improves endothelial function and reduces hypertension. It was found that hexafluoro substantially reduced systolic blood pressure, significantly diminished vascular mitochondrial O 2 . - and improved endothelial nitric oxide. To test the role of endothelial Sirt3 in pharmacological effect of hexafluoro we used endothelial specific Sirt3 knockout mice and angiotensin II model of hypertension. Interestingly, hexafluoro was not effective in endothelial Sirt3 deficient mice supporting specific role of endothelial Sirt3. These studies demonstrate therapeutic potential of genetic and pharmacological endothelial Sirt3 induction after onset of hypertension for treatment of endothelial dysfunction diminishing cardiovascular disease.
Stability of Secondary Recrystallization in Grain‐Oriented Silicon Steel (2008)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussions Conclusion Acknowledgment References
Neutron-Induced Swelling of Commercial Alloys at Very High Exposures (1990)

Density change measurements have been completed on a wide variety of commercially available structural alloys irradiated to neutron fluence levels as large as 2.8 /times/ 10/sup 23/ n/cm/sup 2/ (E > 0.1 MeV) or /approximately/140 dpa in EBR-II at eight temperatures between 399 and 650/degree/C. While there was essentially no swelling in some ferritic alloys and some austenitic superalloys, other austenitic alloys exhibited a wide range of swelling depending on composition, heat treatment and irradiation temperature. The swelling behavior of the austenitic alloy system is shown to reflect primarily the influence of the overall composition and the irradiation temperature on the duration of the transient regime of void swelling, and secondarily to reflect the influence of precipitation and cold work. 16 refs., 6 figs., 5 tabs.
Plasma energies forA−15compounds (1978)

Recent infrared studies by Yao and Schnatterly on ${\mathrm{V}}_{3}$Si and ${\mathrm{Nb}}_{3}$Ge films have determined the optical parameters for these materials, including the Drude plasma energy ${\ensuremath{\Omega}}_{p}$. It is shown that a tight-binding energy-band model, based on augmented-plane-wave and self-consistent pseudopotential calculations, yields plasma energies ${\ensuremath{\Omega}}_{p}$ that are within 20%-25% of these observed values. It is suggested that ${\ensuremath{\Omega}}_{p}$ provides a useful criterion for evaluating the gross features of any band model for the $A\ensuremath{-}15$ compounds, especially since it is relatively insensitive to details such as fine structure in the density of states.
Characterization of Anthocyanins in Grape Juices by Ion Trap Liquid Chromatography−Mass Spectrometry (2003)

A reverse phase HPLC and electrospray interface with ion trap mass spectrometer method was developed for the characterization of anthocyanins in Concord, Rubired, and Salvador grape juices. Rubired and Salvador grapes are hybrids from Vitis vinifera and Vitis rupestris. Concord grape is a grape from the native American cultivar Vitis labrusca. Individual anthocyanins in these three varieties were identified on the basis of UV-vis and MS spectra and further elucidated by MS/MS spectra. Anthocyanins in Salvador and Concord grapes were 3-O-glucosides, 3-O-(6' '-O-p-coumaroyl)glucosides, 3-O-(6' '-O-p-acetyl)glucosides, 3,5-O-diglucosides, and 3-O-(6' '-O-p-coumaroyl)-5-O-diglucosides of delphinidin, cyanidin, petunidin, peonidin, and malvidin. Vitisin B was detected in Salvador grape juice. Anthocyanins in Rubired grape juice were primarily anthocyanin diglucosides: peonidin 3,5-O-diglucoside, malvidin 3,5-O-diglucoside, peonidin 3-O-(6' '-O-p-coumaroyl)-5-O-diglucoside, and malvidin 3-O-(6' '-O-p-coumaroyl)-5-O-diglucoside are the four major anthocyanins. The presence of pelargonidin 3-O-glucoside, not previously reported, has been established for the first time in all three juices.
Application of Digital Anthropometry for Craniofacial Assessment (2014)

Craniofacial anthropometry is an objective technique based on a series of measurements and proportions, which facilitate the characterization of phenotypic variation and quantification of dysmorphology. With the introduction of stereophotography, it is possible to acquire a lifelike three-dimensional (3D) image of the face with natural color and texture. Most of the traditional anthropometric landmarks can be identified on these 3D photographs using specialized software. Therefore, it has become possible to compute new digital measurements, which were not feasible with traditional instruments. The term "digital anthropometry" has been used by researchers based on such systems to separate their methods from conventional manual measurements. Anthropometry has been traditionally used as a research tool. With the advent of digital anthropometry, this technique can be employed in several disciplines as a noninvasive tool for quantifying facial morphology. The aim of this review is to provide a broad overview of digital anthropometry and discuss its clinical applications.
Optical link in the 2.0-6.0-GHz band (1982)

An optical link incorporating 1.1 km of single-mode fiber and operating in the 2.0-6.0-Ghz band was developed. The long link and a 2-m short link were tested for signal, noise, frequency response, group delay distortion, and power linearity. The rf properties of the laser, fiber, detector, and amplifier were separated where possible on the basis of a model. To our knowledge this is the first comprehensive study of the rf properties of a long fiber-optic link in this band.
Compressive Sensing-Based Metrology for Micropositioning Stages Characterization (2016)

High accuracy is a necessary condition for reliable performance of micropositioning stages (MPSs). However, there are various sources of errors that affect their precision. Characterization is a prior step to calibration for compensating systematic errors so as to improve the positioning accuracy. In this letter, the compressive sensing (CS) theory is applied to characterize system errors of MPSs. This method could be flexibly collaborated with any sensors and applicable to widespread microsystems where the motions and errors are required to be measured. CS 1) improves the data acquisition and processing in terms of time and 2) could be employed as an interpolating strategy to efficiently replace the lookup tables. As a case study, the CS-based method is applied to characterize the position-dependent errors of an XY serial MPS. Experimental results show that the method is able to retrieve the microscale positions with largely shortened time and high precision. The spent time for data acquisition and processing is shortened by more than 84% for X stage and 82% for Y stage. These results are especially promising for microscale purposes where the system behavior is varying and difficult to characterize.
Delivering multicast messages in networks with mobile hosts (2002)

There is a strong trend toward integrating portable computers within existing data networks. Traditional network protocols were designed assuming a static view of network connectivity. A mobile host can connect to the network from different locations at different times. This has led to the emergence of a new set of problems with regard to addressing schemes and network protocols for accommodating mobility within existing networks. The authors present a protocol for delivering a multicast message exactly once to a group of mobile destinations. The protocol is based on a system model derived from an architecture developed by J. Ioannidis et al. (1991), for mobile internetworking, relying on mobile support stations within the fixed network to communicate with mobile hosts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Peptococcus magnus: A Significant Human Pathogen (1980)

Peptococcus magnus was recovered from 10% of anaerobic cultures collected from suspected clinical infections over a 3.5-year period. It was the commonest species of anaerobic gram-positive cocci isolated (30%). To evaluate the clinical significance of this organism, we retrospectively reviewed the charts of 222 patients from whom P. magnus was isolated. Twenty-five patients had no evidence of infection, 151 had mixed infections, and 32 had infections from which only P. magnus was isolated (pure cultures). Mixed infections involved the following sites: bone and joint (32 cases), soft tissue (57 cases), foot ulcers (29 cases), abdominal cavity (16 cases), and miscellaneous (17 cases). The average number of organisms was four (2.5 facultatives and 1.5 anaerobes). Eighteen patients with pure cultures of P. magnus had bone or joint infections, and foreign bodies were present in 15 of these. Other pure cultures of P magnus infections included 12 soft tissue, one vascular graft, and one infected sternotomy with persistent bacteremia. Pure culture infections were usually chronic, and serious sequelae often resulted. Peptococcus magnus is frequently isolated from significant infections and seems particularly pathogenic in infections of bones and joints or in association with the presence of foreign bodies, or both.
ASSOCIATION OF PHYSICAL ACTIVITY AND BODY COMPOSITION WITH POSTURAL BALANCE IN THE ELDERLY (2002)

Maintenance of postural balance is an essential component of healthy aging. PURPOSE: To investigate the relationships of physical activity and body composition with postural balance and walking speed in elderly people at the baseline of an exercise intervention trial. METHODS: A random population sample (n = 247) of 70–74 years old men and women was initially invited. Of the 198 eligible subjects, 147 agreed to participate (80 men, 67 women) and they were randomly allocated into an exercise or a reference group for a 4 month aerobic and strength training program. Physical activity and fitness were evaluated using questionnaires. Body mass index (BMI), walst circumference and waist-to-hip ratio were used as measures of body composition. Postural balance was assessed based on standardized field tests. RESULTS: Exercise energy consumption was 970 kcal/week or 180 MET hours/week in both genders. Estimated maximal oxygen uptake correlated with postural balance in men (r = 0.44, p < 0.001) and women (r = 0.30, p = 0.016). BMI and waist circumference correlated negatively with postural balance (r = 0.27, p = 0.001 and r = 0.26, p = 0.003, respectively) and positively with time spent in walking a distance of 20 meters (r = 0.34, p = 0.000 and r = 0.32, p = 0.000, respectively). Waist-to-hip ratio was associated neither with balance nor with walking time. The association between waist circumference and balance was stronger in men (r = 0.38, p = 0.001) while the relationship between BMI and walking time was stronger in women (r = 0.35, p = 0.004). CONCLUSION: Physical fitness and body fatness appear to be important determinants of postural balance in the elderly. These findings emphasize the role of physically active life-style in the prevention of aging-related worsening of postural balance and ensuing falls, and thereby in the maintenance of quality of life.
ChemInform Abstract: Enantioseparation of 5‐Monosubstituted Hydantoins by Capillary Gas Chromatography. Investigation of Chemical and Enzymatic Racemization. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reactions of Cyclic Aliphatic and Aromatic Amines on Ge(100)-2×1 and Si(100)-2×1 (2003)

We have examined the reaction of the Ge(100)-2×1 surface with five-membered cyclic amines including pyrrolidine, 3-pyrroline, pyrrole, and their N-methyl-capped analogues. The reactions of pyrrolidine, N-methylpyrrolidine, pyrrole, and N-methylpyrrole were also probed on the Si(100)-2×1 surface for comparison. Multiple internal reflection (MIR) infrared spectroscopy in combination with density functional theory (DFT) cluster calculations were used to study the reactions. We find that for the aliphatic amines, dative bonding of the N lone pair to the electrophilic down atom of the surface dimer competes with N−H dissociation and [2 + 2] cycloaddition to form stable surface adducts at room temperature and is the major surface reaction observed on the Ge(100) surface. At higher coverages, some evidence for N−H dissociation is seen on the Ge(100) surface. For pyrrole and N-methylpyrrole, the aromatic system of π electrons is seen to have profound effects on their reactivity with the Si(100) and Ge(100) surfaces. The delocalized system of π electrons allows a kinetically favored alternative pathway for N−H dissociation via dative bonding at a ring carbon, resulting in the facile N−H dissociation of pyrrole on the Ge(100) surface, in contrast to the case for aliphatic amines. Evidence is obtained suggesting that pyrrole and N-methylpyrrole also undergo electrophilic aromatic substitution reactions at the surfaces, reactions that have not been previously observed for benzene and other aromatic molecules. We have also compared the known reactivity of pyrrole with its reactivity on Si(100) and Ge(100) and have found interesting similarities, demonstrating that principles used to understand the chemistry of organic molecules can also be applicable and useful for understanding bonding at semiconductor surfaces.
FURTHER CONSIDERATIONS ON THE INCONSISTANCY IN TOUGHNESS EVALUATION OF ULTRA-HIGH STRENGTH STEEL AUSTENITIZED AT INCREASING TEMPERATURES (1977)

A study has been made of the influence of'austenitizing temperature on the ambient temperature toughness of commercial AISI 4340 ultra-high strength steel in the as-quenched (untempered) and quenched and temperedat 200C conditions.As suggested in previous work, a systematic trend of increasing plane strain fracture toughness (K 1 c) and decreasing Charpy V-notch energy is observed as the austenitizing temperature is raised while the yield strength remains unaffected.This effect is seen under both static (slow-bend) and dynamic (impact) loading conditions, and is rationalized in terms of a differing response of the microstructure, produced by each aust~nitizing treatment, to the influence of notch root radius on toughness.Since failure in all microstructures was observed to procede primarily by a ductile rupture (microvoid coalescence) mechanism, an analysis is presented to explain these results, similar to that reported previously for stress-controlled fracture, based on the assumption that ductile rupture can be considered to be strain-controlled.Under such conditions, the decrease in V-notch Charpy energy is associated with a reduction in critical fracture strain at increasing austenitizing temperatures, consistent ., with an observed decrease in uniaxial and plane strain ductility.The increase in sharp-crack fracture toughness, on the other hand, is associated with an increase in "characteristic distance" for ductile fracture, resulting from dissolution of void-initiating particles at high austenitizing temperatures.The microstructural factors which 0 0 fJ {~I 8 0 ,:,~ ' '~ d ;,-'~ ,_ !k~~ ;;) -3affect this behavior are discussed, and in particular the specific role of retained austenite is examined.No evidence was found that the enhancement of fracture toughness at high austeriitizing temperatures was due to the presence of films of retained austenite.The significance of this work on commonly-used Charpy/Klc empirical correlations is briefly discussed.
The Thermal Decomposition of Organic Compounds from the Standpoint of Free Radicals. XI. The Methylene Radical (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Thermal Decomposition of Organic Compounds from the Standpoint of Free Radicals. XI. The Methylene RadicalF. O. Rice and A. L. GlasebrookCite this: J. Am. Chem. Soc. 1934, 56, 11, 2381–2383Publication Date (Print):November 1, 1934Publication History Published online1 May 2002Published inissue 1 November 1934https://pubs.acs.org/doi/10.1021/ja01326a046https://doi.org/10.1021/ja01326a046research-articleACS PublicationsRequest reuse permissionsArticle Views220Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wirelike Charge Transport Dynamics for DNA–Lipid Complexes in Chloroform (2014)

The dynamics of charge separation and charge recombination have been determined for lipid complexes of DNA capped hairpins possessing stilbene electron-acceptor and -donor chromophores separated by base-pair domains that vary in length and base sequence in chloroform solution by means of femtosecond time-resolved transient absorption spectroscopy. The results obtained for the DNA-lipid complexes are compared with those previously obtained in our laboratories for the same hairpins in aqueous buffer. The charge separation and charge recombination times for the lipid complexes are consistently much shorter than those determined in aqueous solution and are only weakly dependent on the number of base pairs separating the acceptor and donor. The enhanced rate constants for forward and return charge transport in DNA-lipid complexes support proposals that solvent gating is responsible, to a significant extent, for the relatively low rates of charge transport for DNA in water. Moreover, they suggest that DNA-lipid complexes may prove useful in the development of DNA-based molecular electronic devices.
APL2: at a glance (1988)

For Jr/Sr level intro to APL and comparative programming languages courses. Tutorial on second generation of APL language.
Iron–copper bimetallic nanoparticles supported on hollow mesoporous silica spheres: the effect of Fe/Cu ratio on heterogeneous Fenton degradation of a dye (2016)

A series of iron–copper bimetallic nanoparticles supported on hollow mesoporous silica spheres with different Fe/Cu ratios were prepared using a simple post-impregnation and sodium borohydride reduction strategy.
Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection (2023)

Rapid, sensitive, simultaneous quantification of multiple biomarkers in point-of-care (POC) settings could improve the diagnosis and management of sepsis, a common, potentially life-threatening condition. Compared to high-end commercial analytical systems, POC systems are often limited by low sensitivity, limited multiplexing capability, or low throughput. Here, we report an ultrasensitive, multiplexed plasmonic sensing technology integrating chemifluorescence signal enhancement with plasmon-enhanced fluorescence detection. Using a portable imaging system, the dual chemical and plasmonic amplification enabled rapid analysis of multiple cytokine biomarkers in 1 h with sub-pg/mL sensitivities. Furthermore, we also developed a plasmonic sensing chip based on nanoparticle-spiked gold nanodimple structures fabricated by wafer-scale batch processes. We used the system to detect six cytokines directly from clinical plasma samples (<i>n</i> = 20) and showed 100% accuracy for sepsis detection. The described technology could be employed in rapid, ultrasensitive, multiplexed plasmonic sensing in POC settings for myriad clinical conditions.
An adaptive rate control algorithm for video coding over personal digital assistants (PDA) (2003)

With the recent development of third-generation communication technologies, encoding live video using a PDA and sharing it among friends has become a reality. However, the embedded processor inside a PDA is still not powerful enough and there are two major hurdles to overcome: (1) video coding needs to meet the rigorous constraint of the available computation capacity of a PDA; (2) In a PDA the computing power allocated to video coding may vary drastically (in bursts). In this paper, a new adaptive rate control algorithm is proposed for video coding over a PDA. This adaptive rate control scheme takes into account the time constraint of a PDA, and its bit allocation depends not only on the available data bits, but more importantly, on the available coding time. Experimental results show that, compared to the existing rate control scheme, the new algorithm can always achieve the maximum frame rate, maximize the utilization of the available bandwidth and computing power, increase the average PSNR, and improve the subjective perceptual quality of the reconstructed video.
Schwann cells seeded in acellular nerve grafts improve functional recovery (2013)

SCs transplanted into CP-ANGs increase functional regeneration to isograft levels; however SC nerve source did not have an effect.