gebhart/patrepeval huggingface dataset:
Nitrogen-Linked Diphosphine Ligands with Ethers Attached to Nitrogen for Chromium-Catalyzed Ethylene Tri- and Tetramerizations (2006)

A series of bis(diphenylphosphino)amine ligands with a donor group attached to the nitrogen linker have been prepared. Metalation of these ligands with chromium trichloride provides precursors to highly active, relatively stable, and selective catalysts for trimerization and tetramerization of ethylene. It has been demonstrated in oligomerization reactions performed at 1 and 4 atm of ethylene that these new systems increase total productivity by enhancing catalyst stability, as compared with those lacking a donor group on the diphosphine ligand. Furthermore, the use of chlorobenzene solvent (rather than toluene) significantly improves productivity, stability, and selectitvity. The product distributions and minor byproducts provide information relevant to mechanistic issues surrounding these types of reactions.
Méthodes physiques contre les ravageurs des cultures et des denrées stockées (2005)

National audience
Gallenblasenkontraktilität, Cholelithiasis und autonome Neuropathie bei Diabetes mellitus (2008)

Decrease in gall-bladder surface area, as obtained by ultrasound, was measured in 52 patients with insulin-dependent diabetes (27 with and 25 without autonomic neuropathy) 60 minutes after administration of the bile stimulant Biloptin. The post-stimulation area was 33 +/- 6% of initial value in patients with autonomic neuropathy, and 67 +/- 8% (P less than 0.0005) in those without autonomic neuropathy. Comparison with insulin-dependent chronic diabetics matched for sex, age and duration of illness, demonstrated that heart-rate variability in cholelithiasis was less than in the control subjects (P less than 0.05). It is concluded that autonomic neuropathy, measured by the occurrence of spontaneous vagotomy, in insulin-dependent diabetics is an important risk factor in the overall pathogenesis of cholelithiasis.
Phase Transitions and Structural Changes in DPPC Liposomes Induced by a 1-Carba-Alpha-Tocopherol Analogue (2021)

Steady-state emission spectroscopy of 1-anilino-8- naphthalene sulfonate (ANS) and 1,6-diphenyl-1,3,5-hexatriene (DPH), fluorescence anisotropy, and DSC methods were used to characterize the interactions of the newly synthesized 1-carba-alpha-tocopherol (CT) with a 1,2-dipalmitoyl-<i>sn</i>-glycero-3-phosphocholine (DPPC) membrane. The DSC results showed significant perturbations in the DPPC structure for CT concentrations as low as 2 mol%. The main phase transition peak was broadened and shifted to lower temperatures in a concentration-dependent manner, and pretransition was abolished. Increasing CT concentrations induced the formation of new phases in the DPPC structure, leading to melting at lower temperatures and, finally, disruption of the ordered DPPC structure. Hydration and structural changes of the DPPC liposomes using ANS and DPH fluorescent probes, which are selectively located at different places in the bilayer, were studied. With the increased concentration of CT molecules in the DPPC liposomes, structural changes with the simultaneous formation of different phases of such mixture were observed. Temperature studies of such mixtures revealed a decrease in the temperature of the main phase transition and fluidization at decreasing temperatures related to increasing hydration in the bilayer. Contour plots obtained from concentration-temperature data with fluorescent probes allowed for identification of different phases, such as gel, ordered liquid, disordered liquid, and liquid crystalline phases. The CT molecule with a modified chromanol ring embedded in the bilayer led to H-bonding interactions, expelling water molecules from the interphase, thus introducing disorder and structural changes to the highly ordered gel phase.
INVESTIGATION OF Ru(IV) SOLUTIONS IN PERCHLORIC AND SULFURIC ACIDS (1965)

Fracture-related infections (FRIs) are classically considered to be early (0−2 weeks), delayed (3−10 weeks) or late (>10 weeks) based on hypothesized differences in causative pathogens and biofilm formation. Treatment strategies often reflect this classification, with debridement, antimicrobial therapy and implant retention (DAIR) preferentially reserved for early FRI. This study examined pathogens isolated from FRI to confirm or refute these hypothesized differences in causative pathogens over time. Cases of FRI managed surgically at three centres between 2015−2019 and followed up for at least one year were included. Data were analysed regarding patient demographics, time from injury and pathogens isolated. Patients who underwent DAIR were also analysed separately. In total, 433 FRIs were studied, including 51 early cases (median time from injury of 2 weeks, interquartile range (IQR) of 1−2 weeks), 82 delayed cases (median time from injury of 5 weeks, IQR of 4−8 weeks) and 300 late cases (median time from injury of 112 weeks, IQR of 40−737 weeks). The type of infection was associated with time since injury; early or delayed FRI are most likely to be polymicrobial, whereas late FRIs are more likely to be culture-negative, or monomicrobial. Staphylococcus aureus was the most commonly isolated pathogen at all time points; however, we found no evidence that the type of pathogens isolated in early, delayed or late infections were different (p = 0.2). More specifically, we found no evidence for more virulent pathogens (S. aureus, Gram-negative aerobic bacilli) in early infections and less virulent pathogens (such as coagulase negative staphylococci) in late infections. In summary, decisions on FRI treatment should not assume microbiological differences related to time since injury. From a microbiological perspective, the relevance of classifying FRI by time since injury remains unclear.
Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites (1999)

Different isoforms of apoE modulate the concentrations of plasma lipoproteins and the risk for atherosclerosis. A novel apoE isoform, apoE4Freiburg, was detected in plasma by isoelectric focusing because its isoelectric point is slightly more acidic than that of apoE4. ApoE4Freiburg results from a base exchange in the APOE4 gene that causes the replacement of a leucine by a proline at position 28. Analysis of the allelic frequencies in whites in southwestern Germany revealed that this isoform is frequent among control subjects (10:4264 alleles) and is even more frequent in patients with coronary artery disease (21:2874 alleles; P=0.004; adjusted odds ratio, 3.09; 95% confidence interval, 1.20 to 7.97). ApoE4Freiburg affects serum lipoproteins by lowering cholesterol, apoB, and apoA-I compared with apoE4 (P<0.05). Our 4 apoE4Freiburg homozygotes suffered from various phenotypes of hyperlipoproteinemia (types IIa, IIb, IV, and V). In vitro binding studies excluded a binding defect of apoE4Freiburg, and in vivo studies excluded an abnormal accumulation of chylomicron remnants. ApoE4Freiburg and apoE4 accumulated to a similar extent in triglyceride-rich lipoproteins. HDLs, however, contained about 40% less apoE4Freiburg than apoE4. In conclusion, our data indicate that apoE4Freiburg exerts its possible atherogenic properties by affecting the metabolism of triglyceride-rich lipoproteins and HDL.
Comparative risk of blindness and vision-threatening ocular comorbidities in patients with Behçet’s disease versus the general population (2022)

In this large population-based cohort study, BD patients compared with the general population have a 10.73-fold risk of blindness in 10 years and also a substantially higher risk of diverse ocular comorbidities that pose potential threats to vision.
La régularisation du Drac par le réservoir du Sautet (1926)

Robert André. La régularisation du Drac par le réservoir du Sautet. In: Revue de géographie alpine, tome 14, n°1, 1926. pp. 219-226.
Enantio- and Regioselective Baeyer−Villiger Oxidations of 2- and 3-Substituted Cyclopentanones Using Engineered Bakers' Yeast (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEnantio- and Regioselective Baeyer−Villiger Oxidations of 2- and 3-Substituted Cyclopentanones Using Engineered Bakers' YeastMargaret M. Kayser, Gang Chen, and Jon D. StewartView Author Information Departments of Chemistry, University of New Brunswick, Saint John, NB, Canada, and University of Florida, Gainesville, Florida 32611 Cite this: J. Org. Chem. 1998, 63, 20, 7103–7106Publication Date (Web):September 9, 1998Publication History Received20 April 1998Published online9 September 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo980737vhttps://doi.org/10.1021/jo980737vbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views822Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chromatography,Fungi,Lactones,Oxidation,Stereoselectivity Get e-Alerts
Human Activity Recognition Based on Symbolic Representation Algorithms for Inertial Sensors (2018)

Mobile sensing has allowed the emergence of a variety of solutions related to the monitoring and recognition of human activities (HAR). Such solutions have been implemented in smartphones for the purpose of better understanding human behavior. However, such solutions still suffer from the limitations of the computing resources found on smartphones. In this sense, the HAR area has focused on the development of solutions of low computational cost. In general, the strategies used in the solutions are based on shallow and deep learning algorithms. The problem is that not all of these strategies are feasible for implementation in smartphones due to the high computational cost required, mainly, by the steps of data preparation and the training of classification models. In this context, this article evaluates a new set of alternative strategies based on Symbolic Aggregate Approximation (SAX) and Symbolic Fourier Approximation (SFA) algorithms with the purpose of developing solutions with low computational cost in terms of memory and processing. In addition, this article also evaluates some classification algorithms adapted to manipulate symbolic data, such as SAX-VSM, BOSS, BOSS-VS and WEASEL. Experiments were performed on the UCI-HAR, SHOAIB and WISDM databases commonly used in the literature to validate HAR solutions based on smartphones. The results show that the symbolic representation algorithms are faster in the feature extraction phase, on average, by 84.81%, and reduce the consumption of memory space, on average, by 94.48%, and they have accuracy rates equivalent to conventional algorithms.
Return to Play in Amateur Soccer Players Undergoing Hip Arthroscopy: Short‐ to Mid‐Term Follow‐Up (2019)

Level IV, case series.
BLSTM-RNN based 3D Gesture Classification (2013)

International audience
A novel technique for the analysis of dielectric height variations in microstrip circuits (1994)

This paper presents a technique based on the full-wave, two-dimensional spectral domain method and the distributed transmission line approach to analyze structures with a combination of conductor width and dielectric height variations. The technique is applied to a regular taper and the results are compared with existing models. A matched taper transition is then designed based on simultaneous variation of the conductor width and dielectric height such that their ratio is kept constant. The analysis of such tapers is carried out and compared to measured data. It is shown that significant reduction in the return loss can be achieved with such transitions over fairly wide, tunable frequency ranges.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structural basis for high specificity of octopine binding in the plant pathogen Agrobacterium tumefaciens (2017)

Abstract Agrobacterium pathogens of octopine- and nopaline-types force host plants to produce either octopine or nopaline compounds, which they use as nutrients. Two Agrobacterium ABC-transporters and their cognate periplasmic binding proteins (PBPs) OccJ and NocT import octopine and nopaline/octopine, respectively. Here, we show that both octopine transport and degradation confer a selective advantage to octopine-type A . tumefaciens when it colonizes plants. We report the X-ray structures of the unliganded PBP OccJ and its complex with octopine as well as a structural comparison with NocT and the related PBP LAO from Salmonella enterica , which binds amino acids (lysine, arginine and ornithine). We investigated the specificity of OccJ, NocT and LAO using several ligands such as amino acids, octopine, nopaline and octopine analogues. OccJ displays a high selectivity and nanomolar range affinity for octopine. Altogether, the structural and affinity data allowed to define an octopine binding signature in PBPs and to construct a OccJ mutant impaired in octopine binding, a selective octopine-binding NocT and a non-selective octopine-binding LAO by changing one single residue in these PBPs. We proposed the PBP OccJ as a major trait in the ecological specialization of octopine-type Agrobacterium pathogens when they colonize and exploit the plant host.
The safety of rolapitant for the treatment of nausea and vomiting associated with chemotherapy (2019)

<b>Introduction</b>: Chemotherapy-induced nausea and vomiting is a significant clinical issue that affects patients' quality of life as well as treatment decisions. Significant improvements in the control of chemotherapy-induced nausea and vomiting have occurred in the past 15 years with the introduction of new antiemetic agents 5-HT3, receptor antagonists, neurokinin-1 receptor antagonists, and olanzapine. Oral (aprepitant, 2003; netupitant, 2014; rolapitant, 2015) neurokinin-1 receptor antagonists have been developed along with intravenous formulations (fosaprepitant, NEPA, rolapitant, HTX-019) for the prevention of chemotherapy-induced nausea and vomiting.<b>Areas covered</b>: This review presents a description of the safety and efficacy of rolapitant along with a comparison to the other oral and intravenous formulations of the neurokinin-1 receptor antagonists.<b>Expert opinion</b>: Oral rolapitant has been demonstrated in clinical trials to be safe and effective in controlling chemotherapy-induced nausea and vomiting in patients receiving moderately and highly emetogenic chemotherapy. Rolapitant has a longer half-life (180 h) than other commercially available NK-1 receptor antagonists and does not induce or inhibit CYP34A, unlike the other NK-1 receptor antagonists. Future studies may determine if these may be important clinical issues.
Impacts of copper products on characteristics of frequency domain dielectric spectroscopy of oil-paper insulation (2013)

The internal copper components in oil-immersed power transformer is susceptible to transformer oil impurities (acid, sulfur and other substances) by the transformer eventually leading to a transformer failure. The accelerated thermal aging tests are conducted on transformer oil-paper insulation to find an effective way to monitor the content of copper-based products and analysis the frequency domain dielectric spectroscopy of the transformer oil-paper insulation system with different contents of copper-based products by using two different sets of sample. The results show that the presence of copper-based products has a little effect on the real part of the complex dielectric constant of the oil-paper insulation, but a great effect on the imaginary part, especially in the middle frequency band (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> Hz ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> Hz). The presence of copper-based products affects the formation of the relaxation mechanism of the oil-paper insulation. The enhanced interfacial polarization and ionic polarization led to the separation of the relaxation center in the middle band. The fitting for the frequency response curve before and after its change by two different relaxation model shows that the new relaxation model is effective.
Literature mining of genetic variants for curation: quantifying the importance of supplementary material (2014)

A major focus of modern biological research is the understanding of how genomic variation relates to disease. Although there are significant ongoing efforts to capture this understanding in curated resources, much of the information remains locked in unstructured sources, in particular, the scientific literature. Thus, there have been several text mining systems developed to target extraction of mutations and other genetic variation from the literature. We have performed the first study of the use of text mining for the recovery of genetic variants curated directly from the literature. We consider two curated databases, COSMIC (Catalogue Of Somatic Mutations In Cancer) and InSiGHT (International Society for Gastro-intestinal Hereditary Tumours), that contain explicit links to the source literature for each included mutation. Our analysis shows that the recall of the mutations catalogued in the databases using a text mining tool is very low, despite the well-established good performance of the tool and even when the full text of the associated article is available for processing. We demonstrate that this discrepancy can be explained by considering the supplementary material linked to the published articles, not previously considered by text mining tools. Although it is anecdotally known that supplementary material contains 'all of the information', and some researchers have speculated about the role of supplementary material (Schenck et al. Extraction of genetic mutations associated with cancer from public literature. J Health Med Inform 2012;S2:2.), our analysis substantiates the significant extent to which this material is critical. Our results highlight the need for literature mining tools to consider not only the narrative content of a publication but also the full set of material related to a publication.
Molecular cloning of the structural gene for porcine thyroid peroxidase. (1987)

We have isolated and determined the nucleotide sequence of overlapping cDNA clones, representing the entire structural gene for pig thyroid peroxidase. The protein coding region extends from an ATG residue at base 252 to a termination codon at base 3030, coding for a 100.4-kDa apoprotein of 926 amino acids. The derived amino acid composition agrees well with the experimentally determined amino acid composition of purified pig thyroid peroxidase. Five potential glycosylation sites are present in the protein. Potential membrane spanning regions are present at the amino-terminal end (1-23) and near the carboxyl-terminal end (845-870) of the protein. These data indicate that pig thyroid peroxidase is synthesized as a single polypeptide that is membrane-bound.
Stable Photocatalytic Paints Prepared from Hybrid Core-Shell Fluorinated/Acrylic/TiO2 Waterborne Dispersions (2016)

The contamination of air and water is one of the major concerns towards the development of a sustainable world in the 21st century. In this context many efforts are devoted to the design of photocatalytic paints able to degrade chemical and biological impurities present in air and water. In this work, the photocatalytic activity of hybrid films formed from the blends of pure acrylic or core/shell fluorinated/acrylic waterborne dispersions and photocatalytic titanium dioxide (TiO2) nanoparticle dispersions was first assessed. The films show photocatalytic activity (inactivation of the Escherichia coli bacteria under UV irradiation) at the substrate-film interface, but very reduced activity in the air-film interface due to the substantially lower amount of the TiO2 nanoparticles in the vicinity of this interface. In a second step, the fluorinated/(meth)acrylic core-shell hybrid dispersions were used as binders in the formulation of waterborne photocatalytic paints and the stability of the paints, in terms of gloss retain and color change, was assessed during 5000 hours of accelerated weathering tests (QUV-B). Although a decrease in gloss retention and increased color change occurs during the first 1000 hours of exposure, no further change of these properties takes place, which is an excellent indication of stable photocatalytic paints.
Irreversible Electrochemical Reaction at High Voltage Induced by Distortion of Mn and V Structural Environments in Na4MnV(PO4)3 (2023)

As the importance of developing low-cost and high-capacity materials is emerging, Mn-based Na4MnV(PO4)3 positive electrode materials that allow multiredox reactions are in the spotlight for Na-ion batteries. The structure that gives highly reversible electrochemical reactions, when two Na+ (out of four) are de-inserted, deteriorates rapidly when the third Na+ is extracted at high voltage, resulting in poor cyclability. In this work, using synchrotron-based operando techniques, we perform long-range and local structural analyses to determine the origins of the rapid structural decay of Na4MnV(PO4)3 when the third Na+ is extracted. Operando XRD shows a significant change in the crystal structure (c parameter increases rapidly) as the occupancy of the Na (1) site decreases at high voltage. The local environments of Mn and V, monitored by operando XAS, remain rather symmetrical up to the extraction of two Na+, while both Mn and V show drastic local distortions when the third Na+ is extracted. These structural degradations are found to further progress when cycling to high voltage. This study presents important aspects of how local and long-range structure modifications can affect the electrochemical performance in multiredox NASICON materials.
Casein phosphopeptides drastically increase the secretion of extracellular proteins in Aspergillus awamori. Proteomics studies reveal changes in the secretory pathway (2012)

In summary, CPPs cause the reprogramming of cellular metabolism, which leads to massive secretion of extracellular proteins.
Single shot approach for three-dimensional imaging with double-helix point spread functions (2016)

A computational imaging approach based on engineered double-helix point spread functions is presented and tested experimentally. It enables the acquisition of three-dimensional object information from a single shot by analyzing the image’s power cepstrum.
Intracellular calcium channels and their modulators (2003)

The ryanodine receptor (RyR) is an essential element in excitation–contraction coupling. Ca2+ release from the sarcoplasmic reticulum (SR) is required for skeletal and heart muscle contraction. The inositol-1,4,5-triphosphate-receptor (IP3R) plays an important function in the signal transduction of many hormones, cytokines, growth factors and antigens, and in fertilisation. Modulators of intracellular calcium channels are used for the treatment of malignant hyperthermia associated with abnormal Ca2+ transport and may be applied in the treatment of cardiovascular and neurodegenerative disorders.