gebhart/patrepeval huggingface dataset:
A new multiaccess technique for multimedia wireless LANs (2002)

This paper presents a novel multiaccess technique that allows multimedia information to be transported in indoor wireless networks. Growing emphasis on multimedia calls for the development of multiaccess protocols capable of supporting demanding applications such as audio/video playback, image browsing, real-time voice/video transmission and interactive data exchange in a unified manner. To this end, a practical multiaccess scheme called "reserved polling" is proposed. The technique handles a diverse mixture of delay classes and message priorities associated with multimedia traffic with an inherent ability to adapt to the traffic load profile. In order to gain a quantitative insight into its behaviour, the protocol is analyzed and simulated in detail.
Increased dietary fat prevents sleep deprivation-induced immune suppression in rats. (2001)

The fat content of rodent diets can have a marked effect on baseline and stress-modulated immune responses.
On a lightwave network topology using Kautz digraphs (1999)

In this paper, the properties of Kautz digraphs are studied to evaluate their suitability as topology for optical networks. The properties are compared to those of other topologies proposed in the literature and it has been shown these topologies have better performance in terms of queuing delay in a multihop network. For a given degree of each node and a given diameter of the network, a Kautz digraph supports more nodes than other topologies, like shufflenet or that of using a de Bruijn digraph, and seems to be an attractive design for the physical topology as well.
Anatomical Changes of the Anterior Chamber Angle With Anterior-Segment Optical Coherence Tomography (2008)

The risk of iridotrabecular contact depends on the height of the iris plane relative to the trabecular meshwork and the degree of physiological dilation of the pupil. Open or narrow angles may become closed in dark lighting conditions, which can lead to the diagnosis of angle-closure glaucoma being missed.
Trends in audio and speech compression for storage and real-time communication (2002)

Summary form only given. Advances in speech compression are generally driven by the need to conserve transmission rate or bandwidth, while maintaining an ability to reconstruct the speech at the receiver with good fidelity. For real-time communication a constant transmission rate and low signal delay for processing are additional requirements. For speech storage applications, variable rate compression techniques which match the short-time compression rate to the nature of the current signal are of significant interest. High-fidelity audio storage systems, such as compact discs require storage rates of roughly 700 kb/s without compression, 1400 kb/s for 2 channel stereo. Reduction to 128 kb/s and even 64 kb/s can be achieved without noticeable degradation by taking advantage of features of the auditory system that permit shaping the quantization noise in time and frequency so that it is best masked by the audio signal. The principal focus of speech compression research is in coding for wireless communication where capacity is limited by the scarce spectrum space available. In particular, a new generation of digital mobile transmission systems is being developed employing 8 kb/s speech coding.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Management aspects of baggage system noise and vibration problems (1975)

Historical problems related to noise and vibration generated by baggage handling equipment in airline terminals, are briefly discussed. Case study of UAL management measures and problems related to insuring a problem-free installation at a major new terminal. hospital operating rooms or research laboratories.
An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats (2022)

Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and confirm our previous study in mice showing immunological and antinociception efficacy of our FEN vaccine administered with the adjuvant dmLT. In this study, immunized male and female rats produced significant levels of anti-FEN antibodies that were highly effective at neutralizing FEN-induced antinociception in the tail flick assay and hot plate assays. The vaccine also decreased FEN brain levels following drug administration. Immunization blocked FEN-induced, but not morphine-induced, rate-disrupting effects on schedule-controlled responding. Vaccination prevented decreases on physiological measures (oxygen saturation, heart rate) and reduction in overall activity following FEN administration in male rats. The impact of FEN on these measures was greater in unvaccinated male rats compared to unvaccinated female rats. Cross-reactivity assays showed anti-FEN antibodies bound to FEN and sufentanil but not to morphine, methadone, buprenorphine, or oxycodone. These data support further clinical development of this vaccine to address OUD in humans.
Nonlinear dynamics in dual frequency capacitive discharges (2008)

This paper proposes an effective nonlinear model which derives from a mathematically demanding spatially resolved model by means of concentrating on the fundamental mode. Based on the obtained mode the interaction of the linear bulk and the nonlinear boundary sheath is analyzed. Comparing the results to traditional linear theory shows that nonlinear effects highly complicate the interaction of bulk and sheath. The low driving frequency as well as the high driving frequency contributes to electron heating within the discharge. It can be shown that this effect of nonlinear electron resonance heating considerably contributes to the total power budget of the discharge. Comparing calculated rf currents with experimentally obtained data provides qualitatively and quantitatively good results.
Follow the dummy: Measuring the influence of a biomimetic robotic fish-lure on the collective decisions of a zebrafish shoal inside a circular corridor (2018)

Robotic agents that are accepted by animals as conspecifics are very powerful tools in behavioral biology because of the ways they help in studying social interactions in gregarious animals. In recent years, we have developed a biomimetic robotic fish lure for the purpose of studying the behavior of the zebrafish Danio rerio. In this paper, we present a series of experiments that were designed to assess the impact of some features of the lure regarding its acceptance among the fish. We developed an experimental setup composed of a circular corridor and a motorized rotating system able to steer the lure inside the corridor with a tunable linear speed. We used the fish swimming direction and distance between the fish and the lure as a metric to characterize the level of acceptance of the lure, depending on various parameters. The methodology presented and the experimental results are promising for the field of animal-robot interaction studies.
Scrapie Infectivity and Proteinase K‐Resistant Prion Protein in Sheep Placenta, Brain, Spleen, and Lymph Node: Implications for Transmission and Antemortem Diagnosis (1998)

Probable transmission of bovine spongiform encephalopathy to humans has focused intense interest on all of the transmissible spongiform encephalopathies (TSEs) and how they spread. In all TSEs, an abnormal disease-associated, proteinase K-resistant protein referred to as PrP-res or PrPsc accumulates in brain. In some species, PrP-res accumulates in other tissues as well. Sheep placenta, brain, spleen, and lymph node were analyzed in detail for PrP-res and infectivity. Both were detected in all brain and spleen samples and in placenta and lymph nodes of 80% of the scrapie-infected sheep. A perfect correlation was observed between infectivity and PrP-res detection. These results substantiate the probability that placenta plays an important role in natural transmission of scrapie, suggest that analysis of placenta for PrP-res could be the basis for an antemortem test for sheep scrapie, and show that PrP-res, scrapie infectivity, and scrapie disease are closely associated.
Two-Dimensional Compaction by 'Zone Refining' (1986)

A new technique for 2-dimensional layout compaction of integrated circuits is presented. After a traditional one-dimensional precompaction step, the size of the layout is further reduced with a technique that bears a strong similarity to the technique of 'zone-refining' used in the purification of crystal ingots. Individual circuit components or small clusters of components are peeled off row by row from the precompacted layout, moved across an open zone, and reassembled at the other end of this zone in a denser configuration. In this process both coordinates of the moved components are altered and jogs are introduced in the connecting wires between them to produce the needed flexibility for placing components into optimal positions. The constraint graphs in both the x- and y-direction are used and updated concurrently.
Pre-Clinical Assessment of Novel Multivalent MSP3 Malaria Vaccine Constructs (2011)

Combination of genetically conserved and antigenically related MSP3 proteins provides promising subunit vaccine constructs, with improved features as compared to the first generation construct employed in clinical trials (MSP3-LSP). These multivalent MSP3 vaccine constructs expand the epitope display of MSP3 family proteins, and lead to the efficient induction of a wider range of antibody subclasses, even in genetically different mice. These findings are promising for future immunization of genetically diverse human populations.
Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs (2018)

Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment. To overcome these barriers, we developed constructs of single-domain antibodies (VHHs) against PD-L1 fused with IL-2 and IFNγ. Targeting cytokine delivery in this manner reduced pancreatic tumor burden by 50%, whereas cytokines fused to an irrelevant VHH, or blockade of PD-L1 alone, showed little effect. Targeted delivery of IL-2 increased the number of intratumoral CD8<sup>+</sup> T cells, whereas IFNγ reduced the number of CD11b<sup>+</sup> cells and skewed intratumoral macrophages toward the display of M1-like characteristics. Imaging of fluorescent VHH-IFNγ constructs, as well as transcriptional profiling, demonstrated targeting of IFNγ to the tumor microenvironment. Many tumors and tumor-infiltrating myeloid cells express PD-L1, rendering them potentially susceptible to this form of targeted immunotherapy. <i>Cancer Immunol Res; 6(4); 389-401. ©2018 AACR</i>.
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin (2009)

TNF alpha and thrombin increased uterine smooth muscle cell collagen contractility while indomethacin had the opposite effect. Thrombin-induced collagen contractility resulted in F2R activation which may in part be mediated by the ROCK-1 pathway. This study established the in vitro human myometrial model as a viable method to assess the effects of a range of uterotonic or uterorelaxant agents on contractility, and also permits investigation of the complex regulatory pathways involved in mediating myometrial contractility at labour.
Regression of left ventricular hypertrophy in experimental renovascular hypertension: diastolic dysfunction depends more on myocardial collagen than it does on myocardial mass (1996)

Losartan and enalapril treatments decreased blood pressure and induced complete regression of LVH in this model of renovascular hypertension. In contrast, none of the treatments induced regression of increased myocardial collagen levels or reduced the abnormal left ventricular diastolic stiffness. These data suggest that diastolic dysfunction depends more on increased myocardial collagen levels than it does on myocardial mass in this model of pathological LVH.
A plasmacytoma-specific factor binds the c-myc promoter region. (1987)

We used an electrophoretic mobility-shift assay to study proteins that bind to sequences in the 5' flanking region of the murine c-myc gene. By comparing the DNA-protein complexes formed with extracts from cells representing earlier stages of B-cell development with those from plasmacytomas, we identified a plasmacytoma-specific protein that binds to a region within the c-myc promoter. Five other regions of this promoter show extensive sequence-specific binding, but the binding is not clearly B-cell stage-specific. Methylation-interference and o-phenanthroline/copper-protection experiments identified a single plasmacytoma-specific protein binding site 290 base pairs 5' of the transcription start site P1. Homologues of a core sequence, d(AGAAAGGGAAAGGA), within the 25-base-pair binding site are found at three additional sites in the murine c-myc locus. The plasmacytoma-specific occurrence of this protein suggests that it may play a role in the transcriptional repression of the normal c-myc gene observed in plasmacytomas.
Synthesis and properties of some 7‐dimethylamino‐1,4‐benzoxazin‐2‐ones (1985)

Abstract The synthesis of the 7‐dimethylamino‐1,4‐benzoxazin‐2‐ones ( 5 ), fluorescent dyes, by condensing α‐keto‐acids with 2‐amino‐5‐dimethylaminophenol is described. When the 3‐substituent is a methyl group, these compounds can be further condensed with aromatic aldehydes to provide the styryl dyes ( 6 ). These products are easily opened by hydrochloric acid in ethanolic solution to afford the corresponding benzalketoacid ethyl esters ( 7 ).
Chitosan microspheres: modification of polymeric chem-physical properties of spray-dried microspheres to control the release of antibiotic drug (1999)

Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 747–759, 1999
P181 COMPARISON OF ECGRAPHIC CRITERIA FOR LEFT VENTRICULAR HYPERTROPHY (2023)

Abstract The diagnosis of Left ventricular hypertrophy (LVH) in the hypertensive patient is important for the prognosis and therapeutic implications that must be more aggressive in hypertensive with organ damage. On the other hand, echocardiography laboratories (Echo) are overwhelmed by an excessive indiscriminate demand for exams in hypertension. Purpose of Work: In a large population of subjects with high blood pressure we tested some ecgraphic standard criteria for LVH Materials and methods: 12859 ecgs with preoperative cardiological examination have been performed in a cardiological surgery consecutively in the last 3 years. From this population was selected a series of 7615 subjects who had carried out an echocardiogram in the last year ( Echo). Average age 66 23 aa, 61% women and 39% males. The sensitivity ( Se) and specificity (Sp) of several LVH ecgraphic criteria were evaluated in this population: Romhilt–Estes score; Sokolow–Lyon; Cornell, Perugia. Echo reference parameters for LVH were left ventricular mass (LVM) and/or diastolic thickness of interventricular septum (IVS) and posterior wall (PW) of the LV reported in the echo taking into account the reference values for LVH of the last LLGG of the European Society of echocardiography. Results The prevalence of IVS on the ecg for the scores studied was respectively 5.9%, 11.9%, 12.8%, 18.5%. The IVS echo prevalence ranged from 27.8% for LVM &amp;gt; 125 g/m2 to 57.1% for LVM &amp;gt; 51g/m2. Using this last parameter or the thickness of the IVS or PW of the LV the Se and Sp of the various scores / criteria were respectively: 6.9% and 95.9% for Romhilt–Estes; 10.9% and 90.8% for Sokolow–Lyon; 15.9% and 92.1% for Cornell; 23.6% and 84.8% for Perugia. Combining the positivity of at least one of three score/ecgraphic criteria ( Romhilt–Estes, Cornell, Perugia) the SE increased to 35.4% with a slight reduction of the SP of 86.5%. Conclusions The ecg Se for LVH is low with a good Sp; combining multiple scores/ecgraphic criteria of LVH, Se increases without a significant reduction of Sp. The ecg could be used to address the execution of the Echo with a better appropriateness and therefore use of resources .
Controlled Trial of Plasma Exchange and Leukapheresis in Polymyositis and Dermatomyositis (1992)

As treatments for corticosteroid-resistant polymyositis or dermatomyositis, leukapheresis and plasma exchange are no more effective than sham apheresis.
Development of µGC (micro gas chromatography) with high performance micromachined chip column (2009)

Abstract A micro gas chromatography (µGC) instrument applying a high performance chip column fabricated on a silicon wafer was developed. Experimental results of the chip column and protyping of a µGC instrument are described. Approximately 35 000 theoretical plates were generated with the chip column coated liquid phase (5% phenyl‐/95% dimethyl‐polysiloxane). The theoretical plates of the chip column were close to those of the capillary column. Experimental minimum height equivalent to a theoretical plate (HETP, H min ) of the chip column was 1.2 times higher than the calculated H min . A prototype µGC applying the chip column was developed. The µGC generated approximately 35 000 theoretical plates, similar to the theoretical plates obtained by a commercial GC instrument. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley &amp; Sons, Inc.
Heterogeneity in Returns to Work Experience: A Dynamic Model of Female Labor Force Participation (2009)

This paper provides structural estimates of heterogeneous returns to work experience for Japanese married women. A dynamic model of labor force participation is used to account for dynamic self-selection into employment. Heterogeneity is incorporated into the model in a way that allows for the multidimensional skill heterogeneity in employment and home production and for the individual-specific slope and curvature of experience effect on earnings. The structural estimates and their comparison to the reduced-form estimates highlight the importance of dynamic self-selection into employment and
Novel Nitric Oxide Releasing Films Based on Inducible Nitric Oxide Synthase and Their Biomedical Applications (2020)

Although a tremendous number of biomaterials are labeled as biocompatible for blood-contacting medical devices, such as vascular grafts, stents, heart valves, and catheters, the thrombogenic nature of these materials can cause serious complications in patients, and eventually functional failure. There are two major limiting factors to clinical application of these materials: 1) platelet activation and thrombus formation, and 2) infection. Nitric oxide (NO) has been known to exert anti-thrombotic, anti-proliferative, and anti-inflammatory effects in the vasculature. Several polymers incorporate NO-generating substances in order to improve biocompatibility of blood-contacting medical devices. However, an important drawback for these NO-release materials is the finite stoichiometric amount of embedded NO that they contain, which could impact their function for long-term or semi-permanent types of implants. In addition, controlling the release rates of NO flux that can be emitted at the polymer/blood interface proved to be challenging, and often requires the addition of other components to the polymer. Therefore, we hypothesized that incorporating the enzyme nitric oxide synthase into polymeric films as functional catalytic units that generate NO would result its antithrombotic coatings with potentially unlimited amounts of NO released. In this project, we use layer-by-layer thin film building strategy to form layers of polyethyleneimine (PEI) and recombinant NOS enzymes as NO-releasing coatings. Charge-based layer-by-layer electrostatic adsorption allows for assembly of multi-component protein/PEI films with defined thickness and catalytic properties. When surfaces coated with PEI/NOS multilayered films are exposed to substrate arginine, a source of reducing equivalents, and other ingredients of the NOS reaction, nitric oxide is formed and released. In this work, we characterize the PEI/NOS thin films in terms of structure of NOS within the films as well as the amount of active NOS. Fourier transform infrared (FTIR) spectroscopic analysis was used to characterize structure-activity relationships of these NOS-containing thin films. We used cyclic voltammetry to determine the active enzyme concentration on the modified surfaces. We also examined how this activity relates to enzymatic activity in terms of NO released fluxes from the thin films. Finally, we assessed the functional performance of these films in terms of the extent to which they counteract platelet adhesion on the coated surfaces. To this end, we used platelet adhesion assays to determine how the number of platelets adsorbed on the PEI/NOS films is affected by the amount of NO released from the PEI/NOS thin films.
Variable-energy positron lifetime study of silicon-oxide films plasma deposited from hexamethyldisiloxane and oxygen mixtures (2000)

Mixtures of hexamethyldisiloxane [HMDSiO, (CH3)3SiOSi(CH3)3] and oxygen are plasma polymerized at different oxygen pressures (P = 1.3–11.4 Pa) and a fixed monomer pressure (Pm = 2.6 Pa). The discharge power is kept at 100 W throughout the work. Nanometer-size holes in the deposited films are characterized by variable-energy positron annihilation lifetime spectroscopy (PALS). Additional information on the film composition and structure is obtained by X-ray photoelectron spectroscopy and IR absorption spectroscopy. The ortho-positronium lifetime τ3 and intensity I3 increase with the P up to 6.2 Pa and then decrease with the P. PALS measurements after annealing at 400°C show that films prepared at high oxygen pressure have a less stable structure than a film deposited at a lower oxygen pressure. These results are discussed in comparison with plasma deposition of pure HMDSiO, as are the possible effects of oxygen radicals on the film structure. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 974–980, 2001