gebhart/patrepeval huggingface dataset:
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia. (2022)

<title>Abstract</title> Schizophrenia is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. Recently, metabolomic studies based on patients’ biofluids and post-mortem brain specimens have revealed altered levels of distinct metabolites between healthy individuals and patients with schizophrenia (SCZ). However, a putative link between dysregulated metabolites and distorted neurodevelopment has not been assessed and access to patients’ material is restricted. In this study, we aimed to investigate a presumed correlation between transcriptomics and metabolomics in a SCZ model using patient-derived induced pluripotent stem cells (iPSCs). iPSCs were differentiated towards cortical neurons and samples were collected longitudinally at defined developmental stages, such as neuroepithelium, radial glia, young and mature neurons. Samples were subsequently analyzed by bulk RNA-sequencing and targeted metabolomics. The transcriptomic analysis revealed dysregulations in several extracellular matrix-related genes in the SCZ samples observed in early neurogenesis, including members of the collagen superfamily. At the metabolic level, several lipid and amino acid discrepancies were correlated to the SCZ phenotype. By employing a novel <italic>in silico</italic> analysis, we correlated the transcriptome with the metabolome through the generation of integrative networks. The network comparison between SCZ and healthy controls revealed a number of consistently affected pathways in SCZ, related to early stages of cortical development, indicating abnormalities in membrane composition, lipid homeostasis and amino acid imbalances. Ultimately, our study suggests a novel approach of correlating <italic>in vitro</italic> metabolic and transcriptomic data obtained from a patient-derived iPSC model. This type of analysis will offer novel insights in cellular and genetic mechanisms underlying the pathogenesis of complex neuropsychiatric disorders, such as schizophrenia.
Stable .eta.4-silatrimethylenemethane transition-metal complexes by the reaction of alkylidenesilirane with metal carbonyl (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable .eta.4-silatrimethylenemethane transition-metal complexes by the reaction of alkylidenesilirane with metal carbonylWataru Ando, Takao Yamamoto, Haruo Saso, and Yoshio KabeCite this: J. Am. Chem. Soc. 1991, 113, 7, 2791–2793Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ja00007a086https://doi.org/10.1021/ja00007a086research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Mountain Research in Europe: An Overview of MAB Research from the Pyrenees to Siberia (1996)

Introduction. MAB-6 Projects in Western Europe: Introduction Austria Switzerland Germany Spain France. MAB in the Mountains of Eastern and Central Europe and the Former USSR: Introduction Former Soviet Union Czech Republic and Slovakia Poland Bulgaria. MAB from the Pyrenees to Siberia: An Evaluation-Models in MAB-6 Projects Organizational and Institutional Issues Lessons for Interdisciplinary Research A Legacy for the Future. Bibliography. Index.
Revisiting the Electronic Structure of Phosphazenes (2005)

Natural bond orbital (NBO) and topological electron density analyses have been used to investigate the electronic structure of phosphazenes [N3P3R6] (R = H, F, Cl, Br, CH3, CF3, N(C2H4); 2R = O2C6H4), [N4P4Cl8], and H[NPCl2]4H. Using the former, the two most likely phosphazene bonding alternatives, negative hyperconjugation and ionic bonding have been critically evaluated. Ionic bonding, as suggested by topological analysis, was found to be the dominant bonding feature, although contributions from negative hyperconjugation are necessary for a more complete bonding description. Substituent effects on the P-N bond have been assessed and cases of bond length alternation have been rationalized using this combined bonding model, which supersedes previous models involving d-orbital participation, leading to an explanation for the observed bond length alternation found in some linear polyphosphazenes. In addition, common aromaticity indicators, nucleus independent chemical shifts (NICS) and para-delocalization indices (PDI), have been determined for the cyclophosphazenes.
Structure of Karman vortex shedding from a yawed cylinder in a uniform flow. (1986)

In order to investigate the effect of yaw angle of Karman vortex shedding from a circular cylinder in a uniform flow, the flow pattern was observed by the smoke wire method. The pressure distribution, secondary flow in the wake along the cylinder and the velocity fluctuation, u, at a point where Karman vortex shedding was clearly observed in the u-signal, were measured. The yaw angle produced a pressure gradient along the cylinder in the dead water region behind it. Secondary flow due to this pressure gradient made the formation of Karman vortex 3-dimensional. The frequency and the regularity of the vortex shedding reduced with increasing yaw angle. When a pair of parallel thin plates was set in the wake to interrupt the secondary flow, the above effects of yaw angle were effectively reduced in the area between them.
An Analysis of Quasi‐Monte Carlo Integration Applied to the Transillumination Radiosity Method (1997)

This paper presents an enhanced transillumination radiosity method that can provide accurate solutions at relatively low computational cost. The proposed algorithm breaks down the double integral of the gathered power to an area integral that is computed analytically and to a directional integral that is evaluated by quasi‐Monte Carlo techniques. Since the analytical integration results in a continuous function of finite variation, the quasi‐Monte Carlo integration that follows the analytical integration will be efficient and its error can be bounded by the Koksma‐Hlawka inequality. The paper also analyses the requirements of the convergence, presents theoretical error bounds and proposes error reduction techniques. The theoretical bounds are compared with simulation results.
Diaqua-μ3-oxido-hexakis(μ2-trichloroacetato-κ2 O:O′)(trichloroacetato-κO)trichromium(III) acetonitrile trisolvate (2008)

In the crystal structure of the title compound, [Cr(3)(C(2)Cl(3)O(2))(7)O(H(2)O)(2)]·3CH(3)CN, the trinuclear [Cr(3)O(H(2)O)(2)(Cl(3)CCO(2))(7)] mol-ecule has an oxide O atom that is connected to one monodentate trichloro-acetate-coordinated and two water-coordinated Cr(III) atoms, the three metal atoms forming the points of an equilateral triangle. Each of the six remaining carboxyl-ate groups bridges a Cr-O-Cr fragment. The cluster inter-acts with the three solvent mol-ecules through water-acetonitrile O-H⋯N hydrogen bonds. Adjacent clusters are linked by a water-carboxylate O-H⋯O hydrogen bond to give a helical chain. One of the CCl(3) groups was found to be disordered over two positions, with the major component having a site-occupancy factor of 0.64 (1).
Cost and Performance Report of Electrical Resistance Heating (ERH) for Source Treatment. Addendum (2008)

Abstract : Electrical Resistance Heating (ERH) was applied at Site 1 located at the U.S. Naval Station Annapolis from January to June 2006. ERH was applied to treat soils and groundwater at depths up to 66 ft below ground surface and contaminated primarily with 1,1,2,2-tetrachloroethane (TeCA), trichloroethylene (TCE), and 1,1,2-trichloroethane (TCA) at the site. This report summarizes the cost and performance data from this ERH application.
Magnetic reconnection at the heliospheric current sheet and the formation of closed magnetic field lines in the solar wind (2006)

[1] We have identified a sunward-directed reconnection exhaust in the solar wind at a crossing of the heliospheric current sheet, HCS, by the ACE spacecraft. The exhaust was embedded within an interval of counterstreaming suprathermal electron strahls that provides direct evidence that reconnection produced closed (i.e., doubly connected to the Sun) magnetic field lines sunward of the reconnection site. We suggest that local, quasi-stationary reconnection at the HCS may, in general, be an important source of closed magnetic field lines often observed in the vicinity of the HCS.
Selector function of MHC I molecules is determined by protein plasticity (2015)

The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules (MHC I) is crucial to the immune response in vertebrates. However, the mechanisms of the rapid selection of high affinity peptides by MHC I from amongst thousands of mostly low affinity peptides are not well understood. We developed computational systems models encoding distinct mechanistic hypotheses for two molecules, HLA-B*44:02 (B*4402) and HLA-B*44:05 (B*4405), which differ by a single residue yet lie at opposite ends of the spectrum in their intrinsic ability to select high affinity peptides. We used in vivo biochemical data to infer that a conformational intermediate of MHC I is significant for peptide selection. We used molecular dynamics simulations to show that peptide selector function correlates with protein plasticity, and confirmed this experimentally by altering the plasticity of MHC I with a single point mutation, which altered in vivo selector function in a predictable way. Finally, we investigated the mechanisms by which the co-factor tapasin influences MHC I plasticity. We propose that tapasin modulates MHC I plasticity by dynamically coupling the peptide binding region and α3 domain of MHC I allosterically, resulting in enhanced peptide selector function.
Morphological control of seedlessly-synthesized gold nanorods using binary surfactants (2018)

High purity gold nanorods (AuNRs) with tunable morphology have been synthesized through a binary-surfactant seedless method, which enables the formation of monocrystalline AuNRs with diameters between 7 and 35 nm. The protocol has high shape yield and monodispersity, demonstrating good reproducibility and scalability allowing synthesis of batches 0.5 l in volume. Morphological control has been achieved through the adjustment of the molar concentrations of cetyltrimethylammonium bromide and sodium oleate in the growth solution, providing fine tuning of the optical scattering and absorbance properties of the AuNRs across the visible and NIR spectrum. Sodium oleate was found to provide greatest control over the aspect ratio (and hence optical properties) with concentration changes between 10 and 23 mM leading to variation in the aspect ratio between 2.8 and 4.8. Changes in the geometry of the end-caps were also observed as a result of manipulating the two surfactant concentrations.
Renormalized anisotropic exchange for representing heat assisted magnetic recording media (2015)

Anisotropic exchange has been incorporated in a description of magnetic recording media near the Curie temperature, as would be found during heat assisted magnetic recording. The new parameters were found using a cost function that minimized the difference between atomistic properties and those of renormalized spin blocks. Interestingly, the anisotropic exchange description at 1.5 nm discretization yields very similar switching and magnetization behavior to that found at 1.2 nm (and below) discretization for the previous isotropic exchange. This suggests that the increased accuracy of anisotropic exchange may also reduce the computational cost during simulation.
Modeling of motion artifacts in contactless heart rate measurements (2013)

Wartzek, Tobias; Brüser, Christoph; Schlebusch, Thomas; Brendle, Christian; Aguiar Santos, Susana; Kerekes, Anna; Gerlach-Hahn, Kurt; Weyer, Sören; Lunze, Katrin; Hoog Antink, Christoph Bernhard; Leonhardt, Steffen
Compensation of IQ imbalance and phase noise in OFDM systems (2005)

Nowadays, a lot of effort is spent on developing inexpensive orthogonal frequency-division multiplexing (OFDM) receivers. Especially, zero intermediate frequency (zero-IF) receivers are very appealing, because they avoid costly IF filters. However, zero-IF front-ends also introduce significant additional front-end distortion, such as IQ imbalance. Moreover, zero-IF does not solve the phase noise problem. Unfortunately, OFDM is very sensitive to the receiver nonidealities IQ imbalance and phase noise. Therefore, we developed a new estimation/compensation scheme to jointly combat the IQ imbalance and phase noise at baseband. In this letter, we describe the algorithms and present the performance results. Our compensation scheme eliminates the IQ imbalance based on one OFDM symbol and performs well in the presence of phase noise. The compensation scheme has a fast convergence and a small residual degradation: even for large IQ imbalance, the overall system performance for an OFDM-wireless local area network (WLAN) case study is within 0.6 dB of the optimal case. As such, our approach greatly relaxes the mismatch specifications and thus enables low-cost zero-IF receivers.
Operative Fixation for Clavicle Fractures—Socioeconomic Differences Persist Despite Overall Population Increases in Utilization (2017)

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Hormonal contraception and risk of venous thromboembolism: national follow-up study (2009)

<b>Objective</b> To assess the risk of venous thrombosis in current users of different types of hormonal contraception, focusing on regimen, oestrogen dose, type of progestogen, and route of administration. <b>Design</b> National cohort study. <b>Setting</b> Denmark, 1995-2005. <b>Participants</b> Danish women aged 15-49 with no history of cardiovascular or malignant disease. <b>Main outcome measures</b> Adjusted rate ratios for all first time deep venous thrombosis, portal thrombosis, thrombosis of caval vein, thrombosis of renal vein, unspecified deep vein thrombosis, and pulmonary embolism during the study period. <b>Results</b> 10.4 million woman years were recorded, 3.3 million woman years in receipt of oral contraceptives. In total, 4213 venous thrombotic events were observed, 2045 in current users of oral contraceptives. The overall absolute risk of venous thrombosis per 10 000 woman years in non-users of oral contraceptives was 3.01 and in current users was 6.29. Compared with non-users of combined oral contraceptives the rate ratio of venous thrombembolism in current users decreased with duration of use (&lt;1 year 4.17, 95% confidence interval 3.73 to 4.66, 1-4 years 2.98, 2.73 to 3.26, and &gt;4 years 2.76, 2.53 to 3.02; P&lt;0.001) and with decreasing dose of oestrogen. Compared with oral contraceptives containing levonorgestrel and with the same dose of oestrogen and length of use, the rate ratio for oral contraceptives with norethisterone was 0.98 (0.71 to 1.37), with norgestimate 1.19 (0.96 to 1.47), with desogestrel 1.82 (1.49 to 2.22), with gestodene 1.86 (1.59 to 2.18), with drospirenone 1.64 (1.27 to 2.10), and with cyproterone 1.88 (1.47 to 2.42). Compared with non-users of oral contraceptives, the rate ratio for venous thromboembolism in users of progestogen only oral contraceptives with levonorgestrel or norethisterone was 0.59 (0.33 to 1.03) or with 75 μg desogestrel was 1.12 (0.36 to 3.49), and for hormone releasing intrauterine devices was 0.90 (0.64 to 1.26). <b>Conclusion</b> The risk of venous thrombosis in current users of combined oral contraceptives decreases with duration of use and decreasing oestrogen dose. For the same dose of oestrogen and the same length of use, oral contraceptives with desogestrel, gestodene, or drospirenone were associated with a significantly higher risk of venous thrombosis than oral contraceptives with levonorgestrel. Progestogen only pills and hormone releasing intrauterine devices were not associated with any increased risk of venous thrombosis.
Feature-Driven Multilayer Visualization for Remotely Sensed Hyperspectral Imagery (2010)

Displaying the abundant information contained in a remotely sensed hyperspectral image is a challenging problem. Currently, no approach can satisfactorily render the desired information at arbitrary levels of detail. In this paper, we present a feature-driven multilayer visualization technique that automatically chooses data visualization techniques based on the spatial distribution and importance of the endmembers. It can simultaneously visualize the overall material distribution, subpixel level details, and target pixels and materials. By incorporating interactive tools, different levels of detail can be presented per users' request. This scheme employs five layers from the bottom to the top: the background layer, data-driven spot layer, pie-chart layer, oriented sliver layer, and anomaly layer. The background layer provides the basic tone of the display; the data-driven spot layer manifests the overall material distribution in an image scene; the pie-chart layer presents the precise abundances of endmember materials in each pixel; the oriented sliver layer emphasizes the distribution of important anomalous materials; and the anomaly layer highlights anomaly pixels (i.e., potential targets). Displays of the airborne AVIRIS data and spaceborne Hyperion data demonstrate that the proposed multilayer visualization scheme can efficiently display more information globally and locally.
Iron Translocation into and out of Listeria innocua Dps and Size Distribution of the Protein-enclosed Nanomineral Are Modulated by the Electrostatic Gradient at the 3-fold “Ferritin-like” Pores (2009)

Elucidating pore function at the 3-fold channels of 12-subunit, microbial Dps proteins is important in understanding their role in the management of iron/hydrogen peroxide. The Dps pores are called "ferritin-like" because of the structural resemblance to the 3-fold channels of 24-subunit ferritins used for iron entry and exit to and from the protein cage. In ferritins, negatively charged residues lining the pores generate a negative electrostatic gradient that guides iron ions toward the ferroxidase centers for catalysis with oxidant and destined for the mineralization cavity. To establish whether the set of three aspartate residues that line the pores in Listeria innocua Dps act in a similar fashion, D121N, D126N, D130N, and D121N/D126N/D130N proteins were produced; kinetics of iron uptake/release and the size distribution of the iron mineral in the protein cavity were compared. The results, discussed in the framework of crystal growth in a confined space, indicate that iron uses the hydrophilic 3-fold pores to traverse the protein shell. For the first time, the strength of the electrostatic potential is observed to modulate kinetic cooperativity in the iron uptake/release processes and accordingly the size distribution of the microcrystalline iron minerals in the Dps protein population.
Photoreflectance spectra of excitonic polaritons in GaN substrate prepared by lateral epitaxial overgrowth (2000)

Photoreflectance (PR) spectra of high-purity, nearly free-standing GaN substrate were compared with emission and reflectance spectra, which were analyzed based on a model exciton-polariton picture in which A, B, and C free excitons couple simultaneously to an electromagnetic wave. The GaN substrate with reduced dislocation density was prepared by lateral epitaxial overgrowth technique and it exhibited predominant excitonic emissions with the decay time nearly 1 ns even at room temperature. The transition energies obtained from the PR spectrum agree with the energies of bottlenecks of the excitonic polariton branches. The result means that perturbation-induced change in the dielectric function is mainly due to polaritons. Temperature dependence of the A-exciton energy was well described using a model which assumes Einstein phonons.
A New Route to Cross-Conjugated Bis(enamines) and an Unusual Reaction with DDQ (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA New Route to Cross-Conjugated Bis(enamines) and an Unusual Reaction with DDQTeresa M. V. D. Pinho e Melo, Ana M. T. D. P. V. Cabral, , Ana M. Beja, José A. Paixão, Manuela R. Silva, Luiz Alte da Veiga, and Thomas L. GilchristView Author Information Departamento de Química and Departamento de Física, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3000 Coimbra, Portugal Chemistry Department, The University of Liverpool, Liverpool L69 7ZD, U.K. Cite this: J. Org. Chem. 1999, 64, 19, 7229–7232Publication Date (Web):August 21, 1999Publication History Received26 January 1999Published online21 August 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/jo9901384https://doi.org/10.1021/jo9901384brief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views460Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Adducts,Alkyls,Conformation,Conjugate acid-base pairs,Hydrocarbons Get e-Alerts
Multiband linear predictive speech coding at very low bit rates (1994)

The authors describe the multiband linear predictive (MB-LPC) vocoder and its operation at 2.4 kb/s and 1.2 kb/s. The MB-LPC vocoder uses mixed excitation and exploits the advantages of both time and frequency domain speech coding techniques to produce natural sounding, good quality speech. Subjective performance of speech at 2.4 kb/s produced by the MB-LPC is very close to that for the 4.15 kb/s INMARSAT-M IMBE speech coder. Informal listening tests have shown that in most cases people could not tell the difference between the new 2.4 kb/s MB-LPC coder and the 4.15 kb/s INMARSAT-M IMBE coder.