gebhart/patrepeval huggingface dataset:
Retinoic Acid Stimulates 17β-Estradiol and Testosterone Synthesis in Rat Hippocampal Slice Cultures (2009)

The hippocampus is essentially involved in learning and memory processes. Its functions are affected by various neuromodulators, including 17beta-estradiol, testosterone, and retinoid. Brain-synthesized steroid hormones act as autocrine and paracrine modulators. The regulatory mechanism underlying brain steroidogenesis has not been fully elucidated. Synthesis of sex steroids in the gonads is stimulated by retinoic acids. Therefore, we examined the effects of retinoic acids on estradiol and testosterone biosynthesis in the rat hippocampus. We used cultured hippocampal slices from 10- to 12-d-old male rats to investigate de novo steroidogenesis. The infant rat hippocampus possesses mRNAs for steroidogenic enzymes and retinoid receptors. Slices were used after 24 h of preculture to obtain maximal steroidogenic activity because steroidogenesis in cultured slices decreases with time. The mRNA levels for P450(17alpha), P450 aromatase and estrogen receptor-beta in the slices were increased by treatment with 9-cis-retinoic acid but not by all-trans-isomer. The magnitude of stimulation and the shape of the dose-response curve for the mRNA level for P450(17alpha) were similar to those for cellular retinoid binding protein type 2, the transcription of which is activated by retinoid X receptor signaling. 9-cis-Retinoic acid also induced a 1.7-fold increase in the protein content of P450(17alpha) and a 2-fold increase in de novo synthesis of 17beta-estradiol and testosterone. These steroids may be synthesized from a steroid precursor(s), such as pregnenolone or other steroids, or from cholesterol, as so-called neurosteroids. The stimulation of estradiol and testosterone synthesis by 9-cis-retinoic acid might be caused by activation of P450(17alpha) transcription via retinoid X receptor signaling.
A Comparison of GRIN Rod Lenses and Planar Ion-exchange Microlenses for the Interconnection of Optoelectronic Device Arrays (1995)

The benefits of optical interconnections to overcome the limitations of conventional metallic connections in electronic computers are widely recognised. To demonstrate the potential of optics several systems have been constructed to interconnect optoelectronic arrays of devices. So-called "smart-pixel" devices are seen as a promising technology in future optoelectonic parallel processing systems.
Cover Picture: Extreme‐Performance Rubber Nanocomposites for and Probing Excavating Deep Oil Resources Using Multi‐Walled Carbon Nanotubes (Adv. Funct. Mater. 21/2008) (2008)

The development of a super rubber sealant, able to withstand temperatures up to 260°C and pressures as high as 239 MPa, through incorporation of surface-controlled multi-walled carbon nanotubes into fluorine rubber is described by Morinobu Endo et al. on page 3403. This novel rubber nanocomposite-derived O-ring with cellulation structure exhibits a balanced pressure resistance, sealing ability, thermal resistance, and durability for probing and excavating deep oil resources, and will contribute as an innovative material to enhanced oil recovery for energy sustainability.
Effective quality control during disaster recovery (2004)

Since September 11, 2001, the increased awareness of homeland security issues has focused a great deal of attention on disaster recovery planning. Plans for mobilizing restoration forces and equipment, along with project management procedures to be used during a recovery, are now, or should be, part of every company's business continuity plan. During a telecommunications disaster recovery, the primary emphasis is on rapid restoration of service. This is appropriate; however, the level of quality with which the work is accomplished will have a great bearing on how the site performs in the future. This paper describes the use of a small, dedicated quality team that balances the need for speed with the need to maintain high-quality standards during restoration services, using examples from the Hinsdale fire restoration of 1988.
High-Resolution Early Earthquake Damage Assessment System for Mexico City Based on a Single-Station (2017)

A high-resolution early earthquake damage assessment system is presented for Mexico City based on real-time computations of seismic spectral intensities at a reference site. To obtain intensities for the entire Mexico Valley, pre-calculated response spectral ratios at soft sites are used. The estimates of seismic intensities (peak ground acceleration, peak ground velocity and spectral ordinates for selected structural periods), together with intensity-damage relations for buildings, fatalities and water supply network were used to obtain the spatial distribution of expected damage throughout the city. The process takes approximately 10 minutes with no human intervention. Since the available time to carry out all the computations is short, we have built a representative building and population database that concentrates all the information in a square mesh of 400 • 400 m. Results are sent to an Emergency Center and to decision makers to trigger previously set emergency plans and to provide information before emergency plans are in full operation.
Optical Coherence Tomography (2013)

Since its invention in the late 1990s, intravascular optical coherence tomography (OCT) has been rapidly adopted in clinical research and, more recently, in clinical practice. Given its unprecedented resolution and high image contrast, OCT has been used to visualize plaque characteristics and to evaluate the vascular response to percutaneous coronary intervention. In particular, OCT is becoming the standard modality to evaluate in vivo plaque vulnerability, including the presence of lipid content, thin fibrous cap, or macrophage accumulation. Furthermore, OCT findings after stent implantation, such as strut apposition, neointimal hyperplasia, strut coverage, and neoatherosclerosis, are used as surrogate markers of the vascular response. New applications for OCT are being explored, such as transplant vasculopathy or non-coronary vascular imaging. Although OCT has contributed to cardiovascular research by providing a better understanding of the pathophysiology of coronary artery disease, data linking the images and clinical outcomes are lacking. Prospective data are needed to prove that the use of OCT improves patient outcomes, which is the ultimate goal of any clinical diagnostic tool. (Circ J 2013; 77: 1933–1940)
The preparation of leukocyte-poor concentrated red cells(CRC) by sepacell-R500 filter. Effect of storage periods of CRC on leukocyte removal. (1990)

We examined the effect of storage periods of CRC on leukocyte removal by Sepacell-R500 filter using fluorescence staining method to determine small numbers of leukocytes in filtrated CRC. The CRCs prepared from 400ml of whole blood and stored for 0, 2 and 10 days were passed through Sepacell-R500 by gravity or at a flow rate for blood transfusion (4ml/min) without priming the filter and suspending CRC with saline. Sepacell-R500 removed more than 99.9% of the leukocytes (the residual leukocyte numbers: less than 8×105) while 89-98% of red cells were recovered from one unit of CRC. There were no significant differences between the pre- and post-filtered red cells in cell volume, osmotic fragility, free hemoglobin contents in supernates, the levels of ATP and 2, 3-DPG and morphological change. The removal rates of leukocytes by the filter were unchanged between the CRC stored for 2 and 10 days. In the case of fresh CRC filtrated through by gravity, the leukocyte removal rate was 95-96% and the remaining leukocytes in the CRC were mostly granulocytes. The phenomenon was due to the higher flow rate and lower granulocyte adhesion than those of CRC stored for 2 and 10 days. On the other hand, the leukocyte removal rate was about 99.9% when fresh CRC was filtrated at the rate of 4ml/min. The filtration procedure at the patient's bedside was excellent for the prepration of leukocyte-poor CRC regardless of storage periods.
A Commercially Scalable Process for Silicon Anode Prelithiation (2017)

During the project, Amprius successfully evaluated new methods and processes for silicon anode prelithiation. Amprius reached several important conclusions: Amprius found that while “in cell” methods are less disruptive to anode production process flows, they are difficult to control with enough reproducibility for high-volume manufacturing. Among the methods evaluated, Amprius determined that the electrochemical prelithiation method is the most flexible, controllable and reproducible. However, the method requires a controlled environment, which would add less than 5% to cell production costs – and potentially much less than 5% if anodes and cells are produced in factories that already have a controlled moisture environment for cell assembly. (In recent years, these factories have become more common as a result of similar moisture sensitivity requirements for high voltage LCO and Nickel-rich NCM cathodes). In developing electrochemical prelithiation electrolyte formulations, Amprius introduced new classes of electrochemical additives for SEI formation and surface protection. These additives are used exclusively in prelithiation and form a more stable SEI structure that increases cycle life by as much as 50%. Since the chemistry and electrochemistry of electrolyte additives is inexhaustible and the SEI affects most performance parameters of lithium-ion cells, the work Amprius performed in this project is only the beginning of a comprehensive study in this direction.
IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination (2007)

The gene affected in the congenital neuropathy familial dysautonomia (FD) is IKBKAP that codes for the IKAP/hELP1 protein. Several different functions have been suggested for this protein, but none of them have been verified in vivo or shown to have some link with the FD phenotype. In an attempt to elucidate the involvement of IKAP/hELP1 in brain function, we searched for IKAP/hELP1 target genes associated with neuronal function. In a microarray expression analysis using RNA extracted from the cerebrum of two FD patients as well as sex and age matched controls, no genes were found to be upregulated in the FD cerebrum. However, 25 genes were downregulated more than 2-fold in the cerebrum of both the male FD child and female FD mature woman. Thirteen of them are known to be involved in oligodendrocyte development and myelin formation. The down regulation of all these genes was verified by real-time PCR. Four of these genes were also confirmed to be downregulated at the protein level. These results are statistically significant and have high biological relevance, since seven of the downregulated genes in the cerebrum of the FD patients were shown by others to be upregulated during oligodendrocyte differentiation in vitro. Our results therefore suggest that IKAP/hELP1 may play a role in oligodendrocyte differentiation and/or myelin formation.
Das Kind als Medium der Erziehung (1991)

Die Frage nach dem Medium der Erziehung greift eine Frage auf, die bisher eher teleologisch und psychologisch beantwortet wurde. Die Einheit der Bemühungen um Erziehung wurden an ihrem Ziel und dieses an der Zustandsveränderung der zu Erziehenden verdeutlicht. Das führt in die Schwierigkeit, daß kein Pädagoge den Innenzustand seines Zöglings, also das, was dieser während des Erzogenwerdens real erlebt, erinnert, erwartet, kennen kann. Und der Nachteil aller Teleologie ist, daß sie keinen Begriff für das doch recht typische Mißlingen der Bemühungen bereitstellt. Diese Art Theorie läßt sich durch die Unterscheidung von Medium und Form ersetzen. Über ein Medium bezieht sich ein System auf die Einheit seiner Operationen. Formen binden das Medium zu festen, aber wieder auflösbaren Einheiten. Für den Fall der Erziehung ist das Medium kein reines Kommunikationsmedium wie Geld oder Macht. Vielmehr dient als Medium die Orientierung an möglichen Bewußtseins- und Körperzuständen des Kindes, die man zu Fähigkeiten, Bildungswerten etc. zu koppeln sucht. Ein Medium fungiert immer nur systemintern, also unabhängig davon, was in den Köpfen und Körpern der Kinder auf Grund psychischer und organischer Eigendetermination faktisch vor sich geht. (DIPF/Orig.)
Thermal and electrical performance and reliability results for cavity-up enhanced BGAs (2003)

A new cavity-up enhanced flex-based BGA package, which adds an integral copper interposer between the die and the flex, expands the options available to the electronic industry for increasing reliability, thermal and electronic package performance, offering improvements compared with many prominent flex-based CSP and BGAs. For board-level reliability, CTE measurements of this enhanced BGA using a moire fringe technique predicted thermal cycling performance similar to /spl mu/BGA and superior to rigid organic laminates, ceramic CSPs and flex-only packages. Package-level reliability testing of the enhanced BGA has identified some common assembly die attach and overmold materials combinations that have performed to JEDEC Level 1 in moisture resistance tests. Thermal computational fluid dynamics (CFD) modeling of the enhanced BGA package with the interposer showed substantially lower junction temperatures in two application environments, as compared to the analogous flex-based package construction without the interposer. Electrical analysis using a boundary element electromagnetic field solver to extract fundamental electrical circuit parameters over a broad range of operating frequencies also predicted electrical performance benefits for the enhanced BGA with interposer versus the same construction without the interposer.
Experimental evaluation of Interference Alignment under imperfect channel state information (2011)

Interference Alignment (IA) has been revealed as one of the most attractive transmission techniques for the K-user interference channel. In this work, we employ a multiuser Multiple-Input Multiple-Output (MIMO) testbed to analyze, in realistic indoor scenarios, the impact of channel state information errors on the sum-rate performance of IA. We restrict our study to a 3-user interference network in which each user transmits a single data stream using two transmit and two receive antennas. For this MIMO interference network, only two different IA solutions exist. We also evaluate the performance gain obtained in practice by using the IA solution that maximizes the sum-rate.
Chromosome Abnormalities in Newborn Babies (1970)

SummaryThe incidence of chromosome abnormalities in the population is discussed with emphasis on current work being done on the screening of newborn babies. Sampling techniques and sample size are discussed. Findings from surveys so far available are summarized and some of their possible implications regarding the Australian population are considered.
Synthesis of [18F] SR144385: a selective radioligand for positron emission tomographic studies of brain cannabinoid receptors (1999)

A cannabinoid receptor antagonist, SR144385, has been labeled with fluorine-18. [18F] SR144385 was synthesized in a multi-step reaction in which fluorine-18 was introduced by nucleophilic halogen displacement on a bromo precursor. The fluorine-18 labeled intermediate was deprotected and coupled with 1-aminopiperidine to give [18F]SR144385. The time for radiosynthesis, HPLC purification, and formulation was 2 hours from end-of-bombardment. [18F] SR144385 of high radiochemical purity was obtained at end-of-synthesis with an average (n=11) specific radioactivity of 1852 mCi/μmol and an average isolated, non-decay corrected radiochemical yield of 4% from potassium [18F] fluoride. Copyright © 1999 John Wiley & Sons, Ltd.
Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors (2015)

Recombinant adeno-associated viruses (rAAVs) are promising vectors in preclinical and clinical assays for the treatment of diseases with gene therapy strategies. Recent technological advances in amplification and purification have allowed the production of highly purified rAAV vector preparations. Although quantitative polymerase chain reaction (qPCR) is the current method of choice for titrating rAAV genomes, it shows high variability. In this work, we report a rapid and robust rAAV titration method based on the quantitation of encapsidated DNA with the fluorescent dye PicoGreen®. This method allows detection from 3×10(10) viral genome/ml up to 2.4×10(13) viral genome/ml in a linear range. Contrasted with dot blot or qPCR, the PicoGreen-based assay has less intra- and interassay variability. Moreover, quantitation is rapid, does not require specific primers or probes, and is independent of the rAAV pseudotype analyzed. In summary, development of this universal rAAV-titering method may have substantive implications in rAAV technology.
Students protest womens' services cuts (2014)

The students for Women Only Services Group held a vigil in Sydney on July 24 to protest against the recent decision to defund specialist women's and children's refuge centres in NSW.
Zero-mode dispersion in single-mode fibres (1978)

Near cutoff the loss of the LP11-mode in cladded optical fibres becomes very high in the presence of even slight bends. Singlemode operation can thus be achieved with zero-mode dispersion as well as zero material dispersion, thus promising enormously large bandwidths.
Singing for Leadership: Fostering the Development of Female Leaders through Voice (2010)

This study investigates the link between development of voice via participation in singing, and the development of leadership qualities and capabilities in women. Voice is discussed as a metaphor for both leadership and personal leadership development, and the issue of how female voices are dismissed and/or suppressed is considered. The theoretical framework that undergirds this exploration is transformative learning, which is a process of making meaning of one’s life experiences. Singing can be a transformative learning process that facilitates a shift away from self-limiting attitudes and toward developing leadership qualities in women via experiential learning, learning within relationship, public performance, and the inner journey of reflection and subsequent understanding that leads to individuation. Three main themes emerged from this study that characterize the personal development and growth that participation in singing can foster: commitment, connection, and congruence.
Etude des spectres de vibration des dérivés monosubstitués en position 5 de l'isothiazole (1975)

The i.r. absorption spectra in different physical states and the Raman spectra in the liquid or solid state of 5-monosubstituted isothiazole derivatives, C 3 NSH 2 Y (Y = CH 3 , CD 3 , Cl, Br, I) have been analyzed. An assignment of the fundamental modes of vibration of these molecules is given.
Point-of-Care device for quantification of zinc in serum (2013)

With 42,000 cases reported annually in the United States and an approximate 10% mortality rate, [1] pediatric septic shock is a major health problem that is often difficult to treat effectively. Several studies have shown that children experiencing pediatric septic shock often have critically low levels of serum zinc (Zn), suggesting supplementation of Zn to be an effective therapeutic strategy. However, to protect the safety and well-being of the patient, it is extremely important to monitor blood serum concentration of Zn during supplementation in order to ensure that levels remain at or near the physiological norm and thus minimize the risk of heavy metal toxicity from over supplementation. Current methods for quantifying Zn in serum typically require sending serum samples to external laboratory facilities resulting in turnaround times ranging from hours to a few days. Therefore, timely monitoring of Zn levels in serum is often not possible in the clinical setting which ultimately limits the ability to use Zn supplementation as a therapeutic intervention. This paper reports on the development of a Point-of-Care device for rapid electrochemical measurement of Zn in serum. The device is centered on a three electrode sensor which uses Anodic stripping voltammetry (ASV) for sensing Zn levels. The Cu based sensor is read using a reader that has been developed using commercially available embedded system parts in combination with custom analog circuitry that is able to produce quantification results in approximately 6 minutes.
Gold Electroplating by Disulfiteaurate Complex. (1993)

The decomposition mechanism of gold sulfite plating baths was investigated and stabilizing agents were evaluated with a view to improving bath stability. It was confirmed that Au metal and Au3+ ion were produced at bath decomposition, which proceeded based on a 3 Au+ 2Au + Au3+ disproportionation reaction. This shows bath stability will be improved by inhibiting the disproportionation reaction and the most effective agents that were inhibiting the dispropotionation of Au+ and thus improving bath stability were 2,2'-dipyridyl and its derivatives including 0-phenanthroline and neocuproin. The Vickers hardness of the deposit from baths containing 2,2'-dipyridyl was 66Hv, and the stress was lower than for the standard bath. Brightness was improved by the addition of As3+, but hardness and stress were increased.
Application of Lignin and Its Derivatives in Adsorption of Heavy Metal Ions in Water: A Review (2018)

Water pollution by heavy metal ions is currently of great concern due to their high toxicity and carcinogenicity. In recent years, great efforts have been devoted to the search for new cost-effective adsorbents derived from biomass. Lignin is a natural amorphous polymer that has great potential for use as a building block in the production of biorenewable materials. Due to its unique polyphenol structure, physicochemical properties, and abundance, a wide variety of sorbents, particularly heavy metal ion sorbents, can be potentially obtained from lignin. This paper provides a comprehensive review of the literature about different feedstock lignin and versatile lignin derivatives used as heavy metal ion adsorbents. The adsorption capability improvement mechanism of the lignin derivatives and the comparison with commercial resins are also discussed. Therefore, this review aims to discuss the different modification categories that have been reported for the conversion of lignins into advanced heavy metal ion adsorbents. Most importantly, adsorbents derived from lignin can confer high environmental benefits due to its stability, biocompatibility and abundance in the plant kingdom. This review may pave the way for the design and fabrication of new lignin-based adsorbents with enhanced adsorbent performance for heavy metal ions in water.
A Novel Cu(II) Carrier with High Efficiency and Selectivity for Proton-driven Uphill Transport through Liquid Membranes (1990)

Abstract N-(8-Quinolyl)-N′-(2-pyridylmethyl)malonamide derivative, which has been synthesized as carrier for transition metal ions, can transport Cu(II) with high selectivity against its concentration gradient through liquid membranes.