gebhart/patrepeval huggingface dataset:
The path of calcium in cytosolic calcium oscillations: a unifying hypothesis. (1991)

Data from 42 systems have been assembled in which the overall spatial course of relatively natural, intracellular calcium pulses has been or can be determined. These include 21 cases of solitary pulses in activating eggs and 21 cases of periodic (as well as solitary) pulses in various fully active cells. In all cases, these pulses prove to be waves of elevated calcium that travel from one pole of a cell to the other or from the periphery inward. The velocities of these waves are remarkably conserved--at approximately 10 microns/sec in activating eggs and approximately 25 microns/sec in other cells at room temperature. Moreover, in three cases, the data suffice to show that these velocities fit the Luther equation for a reaction/diffusion wave of calcium through the cytosol. It is proposed that (i) natural intracellular calcium pulses quite generally take the form of cytosolic calcium waves and (ii) cytoplasmically controlled calcium waves are triggered and then propagated by the successive action of two distinct modes of calcium-induced calcium release. First, in the lumenal mode, a slow increase of calcium within the lumen of the endoplasmic reticulum reaches a level that triggers fast lumenal release as well as fast localized release into the cytosol. Then, the well-known cytosolic mode drives a reaction/diffusion wave across or into the cell.
PARTICLE COUNTING OIL AND WATER EMULSIONS (1989)

ABSTRACT Because of their speed and convenience, optical particle counters are widely used for particle size analysis of liquid samples. In some cases, both solid particles and emulsified water or oil may be present in a sample. Since emulsion droplets are counted as if they are solid particles, analysis and data interpretation for these samples are difficult. Until recently, no suitable method existed for distinguishing solid contaminants from emulsion droplets. This paper discusses a method which overcomes this limitation. Through the use of a surfactant-laden nonpolar dilution fluid, water is incorporated into reverse micelles too small to be seen by most optical particle counters. As a result, only solid contaminants are counted, and many problems associated with the analysis of emulsions are overcome. Results obtained from a wide range of oil and water emulsions are used to evaluate the merits and possible applications of the new technique.
Topology adaptive deformable surfaces for medical image volume segmentation (1999)

Deformable models, which include deformable contours (the popular snakes) and deformable surfaces, are a powerful model-based medical image analysis technique. We develop a new class of deformable models by formulating deformable surfaces in terms of an affine cell image decomposition (ACID). Our approach significantly extends standard deformable surfaces, while retaining their interactivity and other desirable properties. In particular, the ACID induces an efficient reparameterization mechanism that enables parametric deformable surfaces to evolve into complex geometries, even modifying their topology as necessary. We demonstrate that our new ACID-based deformable surfaces, dubbed T-surfaces, can effectively segment complex anatomic structures from medical volume images.
<title>The Design Of A Multi-Detector Spectrometer For The Infrared</title> (1978)

A modified Ebert-Fastie spectrometer has been designed for use as an atmospheric temperature sounder. It uses a fixed grating, and the first four orders are imaged onto a set of rigidly mounted detectors. Some fundamental properties of the design are reviewed, and some interesting imaging properties are discussed.
An ensemble learning approach for the Kaggle taxi travel time prediction challenge (2015)

This paper describes the winning solution to the Taxi Trip Time Prediction Challenge run by Kaggle.com. The goal of the competition was to build a predictive framework that is able to predict the final destination and the total traveling time of taxi rides based on their (initial) partial trajectories. The available data consists of all taxi trips of 442 taxis running in the city of Porto within one year. The presented solution consists of an ensemble of expert models combined with a spatial clustering approach. The base classifiers consist of Random Forest Regressors where as the expert models for each test trip where based on a combination of gradient boosting and random forest. The paper shows how these models can be combined in order to generate accurate predictions of the remaining traveling time of a taxi.
Machine learning assisted remote forestry health assessment: a comprehensive state of the art review (2023)

Forests are suffering water stress due to climate change; in some parts of the globe, forests are being exposed to the highest temperatures historically recorded. Machine learning techniques combined with robotic platforms and artificial vision systems have been used to provide remote monitoring of the health of the forest, including moisture content, chlorophyll, and nitrogen estimation, forest canopy, and forest degradation, among others. However, artificial intelligence techniques evolve fast associated with the computational resources; data acquisition, and processing change accordingly. This article is aimed at gathering the latest developments in remote monitoring of the health of the forests, with special emphasis on the most important vegetation parameters (structural and morphological), using machine learning techniques. The analysis presented here gathered 108 articles from the last 5 years, and we conclude by showing the newest developments in AI tools that might be used in the near future.
Online anomaly detection over Big Data streams (2015)

Data quality is a challenging problem in many real world application domains. While a lot of attention has been given to detect anomalies for data at rest, detecting anomalies for streaming applications still largely remains an open problem. For applications involving several data streams, the challenge of detecting anomalies has become harder over time, as data can dynamically evolve in subtle ways following changes in the underlying infrastructure. In this paper, we describe and empirically evaluate an online anomaly detection pipeline that satisfies two key conditions: generality and scalability. Our technique works on numerical data as well as on categorical data and makes no assumption on the underlying data distributions. We implement two metrics, relative entropy and Pearson correlation, to dynamically detect anomalies. The two metrics we use provide an efficient and effective detection of anomalies over high velocity streams of events. In the following, we describe the design and implementation of our approach in a Big Data scenario using state-of-the-art streaming components. Specifically, we build on Kafka queues and Spark Streaming for realizing our approach while satisfying the generality and scalability requirements given above. We show how a combination of the two metrics we put forward can be applied to detect several types of anomalies - like infrastructure failures, hardware misconfiguration or user-driven anomalies - in large-scale telecommunication networks. We also discuss the merits and limitations of the resulting architecture and empirically evaluate its scalability on a real deployment over live streams capturing events from millions of mobile devices.
Feedback responses during sequential inhibition of angiotensin and thromboxane (1990)

Since thromboxane (Tx) can mediate the actions of angiotensin II (ANG II), we investigated interaction between these systems on the tubuloglomerular feedback (TGF) response. TGF was assessed from proximal stop-flow pressure (PSF) during orthograde perfusion of the loop of Henle (LH) between 0 and 40 nl/min. In the basal state, TGF was 11.3 +/- 0.8 mmHg. In series 1 experiments, it was unaltered by vehicle (+0.3 +/- 0.9 mmHg, n = 9, NS), was reduced by an ANG II antagonist, saralasin (-2.4 +/- 1.1 mmHg, n = 8, P less than 0.0005), and by a TxA2 antagonist SQ 29,548 (-4.8 +/- 0.6 mmHg, n = 11, P less than 0.0001). Both drugs together produced an additive blunting of TGF of -6.9 +/- 0.7 mmHg. In series 2 experiments, TGF was again unchanged by vehicle (+0.2 +/- 0.6 mmHg). It was reduced by -4.4 +/- 0.2 mmHg (P less than 0.0001) by an angiotensin-converting enzyme inhibitor CGS-14,824A (50 mg/kg, n = 5) and by -4.0 +/- 0.4 mmHg (P less than 0.001) by a Tx synthesis inhibitor CGS-13,080 (50 mg/kg, n = 7). Although both drugs together produced a further blunting of the response of -6.1 +/- 0.4 mmHg, this was significantly (P less than 0.001) less than additive. In both series, a response (averaging 3.5 +/- 0.3 mmHg) persisted in all rats given combined antagonists or inhibitors. In conclusion, both ANG II and TxA2 can modulate TGF-induced changes in PSF independently, and the response probably requires other system(s) in addition to ANG II and TxA2.
Quantitative comparison of the dynamic flow waveform changes in 12 ruptured and 29 unruptured ICA–ophthalmic artery aneurysms (2013)

Quantitative analysis which considers temporal blood flow changes appears to provide additional information which is not apparent from aneurysmal flow at a single time point (i.e., peak of systole). By considering the flow waveform throughout the cardiac cycle, statistically significant differences were found between ruptured and unruptured cases - for flow profile, pulsatility and timing of peak flow.
Spatio-temporal registration of electro-anatomical mappings with functional data for CRT optimization (2012)

International audience
Synthesis and Absolute Configuration of MQ-A3[1-(14'-Methylhexadecanoyl) pyrrolidine], a Novel Aliphatic Pyrrolidine Amide from the Tropical Convolvulaceous Species (2001)

A novel pyrrolidine amide (MQ-A3) isolated from the tropical convolvulaceous species was synthesized in 5 steps by starting from commercially available 12-bromododecanol and (S)-2-methylbutylbromide. The absolute configuration of the natural product was confirmed by a comparison of the specific rotation values.
RECENT LITERATURE ON “WHITE-COLLAR CRIME” (1963)

Journal Article RECENT LITERATURE ON “WHITE-COLLAR CRIME” Get access STRAFRECHTSPFLEGE UND STRAFRECHTSREFORM. [Wiesbaden: Bundeskriminalamt, 1961.] H. M. H. M. Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 3, Issue 4, April 1963, Page 409, https://doi.org/10.1093/oxfordjournals.bjc.a048650 Published: 01 April 1963
A machine learning approach for retinal images analysis as an objective screening method for children with autism spectrum disorder (2020)

Because ARIA is a fully automatic cloud-based algorithm and relies only on retinal images, it can be used as a risk assessment tool for ASD screening. Further diagnosis and confirmation can then be made by professionals, and potential treatment may be provided at a relatively early stage.
Reactions of Benzaldehyde with Thiazolium Salts in Me2SO: Evidence for Initial Formation of 2-(.alpha.-Hydroxybenzyl)thiazolium by Nucleophilic Addition, and for Dramatic Solvent Effects on Benzoin Formation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Benzaldehyde with Thiazolium Salts in Me2SO: Evidence for Initial Formation of 2-(.alpha.-Hydroxybenzyl)thiazolium by Nucleophilic Addition, and for Dramatic Solvent Effects on Benzoin FormationYao-Tsung Chen, Gabriel L. Barletta, Khadijah Haghjoo, Jung Tsang Cheng, and Frank JordanCite this: J. Org. Chem. 1994, 59, 25, 7714–7722Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00104a030https://doi.org/10.1021/jo00104a030research-articleACS PublicationsRequest reuse permissionsArticle Views1002Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sowing the “CEED”s of a more diverse biomedical workforce: The Career Education and Enhancement for Health Care Research Diversity (CEED) program at the University of Pittsburgh (2019)

Programs that support URB researchers can help expand and diversify the biomedical research workforce. CEED has been successful despite the challenges of a small demographic pool.
Preparation and polymerization of the two isomeric (chloromethyl)oxetanes (1990)

Abstract 2‐(Chloromethyl)oxetane was prepared in 8% overall yield from 2‐propen‐1‐ol by protection of the alcohol with dihydropyran, epoxidation, ring expansion with dimethylsulfoxonium methylide, acid deprotection, and chlorination with triphenylphosphine in CCl 4 . 3‐(Chloromethyl)oxetane was prepared in 22% overall yield by hydroboration‐oxidation of 3‐chloro‐2‐chloromethyl‐1‐propene followed by base‐catalyzed cyclization. Each of the oxetanes was converted to the corresponding elastomeric homopolymer by treatment with a triethylaluminum–acetylacetone–water mixture. Poly[2‐(chloromethyl)oxetane] was found to be similar to polyepichlorophydrin in reactivity toward benzoate ion, whereas poly[3‐(chloromethyl)oxetane] is more reactive by a factor of 2.
[New strategy of cancer immunotherapy: irradiation or chemotherapeutics-induced lymphopenia combined with immune reconstitution and tumor vaccine]. (2005)

This study suggests that vaccination of RLM could elicit augmented antitumor immunity compared to normal hosts, highlighting the potential clinical benefit of performing tumor vaccination during irradiation or chemotherapeutics-induced lymphopenia in cancer patients.
EFFECT OF INTERMETALLIC PHASES ON CORROSION BEHAVIOR AND MECHANICAL PROPERTIES OF DUPLEX STAINLESS STEEL AND SUPER-DUPLEX STAINLESS STEEL (2015)

Duplex Stainless Steels (DSS) and Super Duplex Stainless Steel (SDSS) have excellent integration of mechanical and corrosion properties. However, the formation of intermetallic phases is a major problem in their usage. The mechanical and corrosion properties are deteriorated due to the presence of intermetallic phases. These phases are induced during welding, prolonged exposure to high temperatures, and improper heat treatments. The main emphasis of this review article is on intermetallic phases and their effects on corrosion and mechanical properties. First the effect of various alloying elements on DSS and SDSS has been discussed followed by formation of various intermetallic phases. The intermetallic phases affect impact toughness and corrosion resistance significantly. Their deleterious effect on weldments has also been reviewed.
Diesel Exhaust Particle-Induced Airway Responses are Augmented in Obese Rats (2014)

Air pollutants and obesity are important factors that contribute to asthma. The aim of this study was to assess the airway responsiveness and inflammation in Otsuka-Long Evans Tokushima Fatty (OLETF) obese rats and Long Evans Tokushima-Otsuka (LETO) nonobese rats exposed to diesel exhaust particles (DEPs). Otsuka Long Evans Tokushima fatty rats and LETO rats were exposed intranasally to DEP and then challenged with aerosolized DEP on days 6 to 8. Body plethysmography, bronchoalveolar lavage (BAL), and histology were performed. Enhanced pause (Penh) was measured as an indicator of airway resistance on day 9 and samples were collected on day 10. After exposure to DEP, the OLETF group exhibited a greater increase in Penh compared to that in the LETO group. Moreover, the BAL fluid in mice showed an increase in the total and differential cell counts in the DEP-exposed OLETF group compared to that in the DEP-exposed LETO group. Histological assessment of lung tissue from each group revealed that the DEP-exposed OLETF group tended to have increased inflammatory cell infiltrations in the prebronchial area. Increased peroxisome proliferator-activated receptor γ, coactivator 1β messenger RNA was observed in the lungs of obese rats compared to that in nonobese rats following DEP exposure. These data indicate that the DEP-exposed OLETF group had increased airway responses and inflammation compared to the DEP-exposed LETO group, indicating that diesel particulates and obesity may be co-contributors to asthma.
Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes (2009)

Transposable elements (TEs) are major sources of new exons in higher eukaryotes. Almost half of the human genome is derived from TEs, and many types of TEs have the potential to exonize. In this work, we conducted a large-scale analysis of human exons derived from mammalian-wide interspersed repeats (MIRs), a class of old TEs which was active prior to the radiation of placental mammals. Using exon array data of 328 MIR-derived exons and RT-PCR analysis of 39 exons in 10 tissues, we identified 15 constitutively spliced MIR exons, and 15 MIR exons with tissue-specific shift in splicing patterns. Analysis of RNAs from multiple species suggests that the splicing events of many strongly included MIR exons have been established before the divergence of primates and rodents, while a small percentage result from recent exonization during primate evolution. Interestingly, exon array data suggest substantially higher splicing activities of MIR exons when compared with exons derived from Alu elements, a class of primate-specific retrotransposons. This appears to be a universal difference between exons derived from young and old TEs, as it is also observed when comparing Alu exons to exons derived from LINE1 and LINE2, two other groups of old TEs. Together, this study significantly expands current knowledge about exonization of TEs. Our data imply that with sufficient evolutionary time, numerous new exons could evolve beyond the evolutionary intermediate state and contribute functional novelties to modern mammalian genomes.
Macrophages—Key cells in the response to wear debris from joint replacements (2013)

The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening, and revision surgery. The latter may be indicated in up to 15% patients in the decade following the arthroplasty using conventional polyethylene. Macrophages play multiple roles in both inflammation and in maintaining tissue homeostasis. As sentinels of the innate immune system, they are central to the initiation of this inflammatory cascade, characterized by the release of proinflammatory and pro-osteoclastic factors. Similar to the response to pathogens, wear particles elicit a macrophage response, based on the unique properties of the cells belonging to this lineage, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The biological processes involved are complex, redundant, both local and systemic, and highly adaptive. Cells of the monocyte/macrophage lineage are implicated in this phenomenon, ultimately resulting in differentiation and activation of bone resorbing osteoclasts. Simultaneously, other distinct macrophage populations inhibit inflammation and protect the bone-implant interface from osteolysis. Here, the current knowledge about the physiology of monocyte/macrophage lineage cells is reviewed. In addition, the pattern and consequences of their interaction with wear debris and the recent developments in this field are presented.
PID controllers: Design and tuning methods (2014)

In the paper recent design and tuning methods of PID controllers are summarized briefly. Several decades have seen the widely application of PID controllers and the design and tuning methods have been of considerable development. Process model identification, PID controller structure design, PID parameters tuning methods and the use and expansions of PID are described in turn. PID parameter tuning methods are highlighted.
Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide (2023)

In recent years, bone tissue engineering (BTE) has made significant progress in promoting the direct and functional connection between bone and graft, including osseointegration and osteoconduction, to facilitate the healing of damaged bone tissues. Herein, we introduce a new, environmentally friendly, and cost-effective method for synthesizing reduced graphene oxide (rGO) and hydroxyapatite (HAp). The method uses epigallocatechin-3-O-gallate (EGCG) as a reducing agent to synthesize rGO (E-rGO), and HAp powder is obtained from Atlantic bluefin tuna (Thunnus thynnus). The physicochemical analysis indicated that the E-rGO/HAp composites had exceptional properties for use as BTE scaffolds, as well as high purity. Moreover, we discovered that E-rGO/HAp composites facilitated not only proliferation, but also early and late osteogenic differentiation of human mesenchymal stem cells (hMSCs). Our work suggests that E-rGO/HAp composites may play a significant role in promoting the spontaneous osteogenic differentiation of hMSCs, and we envision that the E-rGO/HAp composites could serve as promising candidates for BTE scaffolds, stem cell differentiation stimulators, and implantable device components due to their biocompatible and bioactive properties. Overall, we suggest a new approach for developing cost-effective and environmentally friendly E-rGO/HAp composite materials for BTE application.
Video capsule endoscopy in pediatric patients with Crohn’s disease: a single-center experience of 180 procedures (2018)

VCE is a safe method in children with suspected or established CD. VCE often leads to a definitive diagnosis and has a significant impact on the clinical management of pediatric patients with CD.
Diagnostic Value of the Fimbriae Distribution Pattern in Localization of Urinary Tract Infection (2021)

Urinary tract infections (UTIs) are one of the most common infectious diseases. UTIs are mainly caused by uropathogenic <i>Escherichia coli</i> (UPEC), and are either upper or lower according to the infection site. Fimbriae are necessary for UPEC to adhere to the host uroepithelium, and are abundant and diverse in UPEC strains. Although great progress has been made in determining the roles of different types of fimbriae in UPEC colonization, the contributions of multiple fimbriae to site-specific attachment also need to be considered. Therefore, the distribution patterns of 22 fimbrial genes in 90 UPEC strains from patients diagnosed with upper or lower UTIs were analyzed using PCR. The distribution patterns correlated with the infection sites, an XGBoost model with a mean accuracy of 83.33% and a mean area under the curve (AUC) of the receiver operating characteristic (ROC) of 0.92 demonstrated that fimbrial gene distribution patterns could predict the localization of upper and lower UTIs.