gebhart/patrepeval huggingface dataset:
Clinical Role of Respiratory Virus Infection in Acute Otitis Media (1990)

The clinical characteristics of acute otitis media in relation to coexisting respiratory virus infection were studied in a 1-year prospective study of 363 children with acute otitis media. Respiratory viruses were detected using virus isolation and virus antigen detection in nasopharyngeal specimens of 42% of the patients at the time of diagnosis. Rhinovirus (24%) and respiratory syncytial virus (13%) were the two most common viruses detected. Adenovirus, parainfluenza viruses, and coronavirus OC43 were found less frequently. The mean duration of preceding symptoms was 5.9 days before the diagnosis of acute otitis media. Ninety-four percent of the children had symptoms of upper respiratory tract infection. Fever was reported in 55% and earache in 47% of cases. Patients with respiratory syncytial virus infection had fever, cough, and vomiting significantly more often than patients with rhinovirus infection or virus-negative patients. No significant differences were found in the appearance of the tympanic membrane and outcome of illness between virus-negative and virus-positive patients with acute otitis. Most patients respond well to antimicrobial therapy despite the coexisting viral infection. If the symptoms of infection persist, they can be due to the underlying viral infection, and viral diagnostics preferably with rapid methods may be clinically useful in these patients.
Patient Eligibility for Randomized Controlled Trials in Critical Care Medicine: An International Two-Center Observational Study* (2016)

Slightly more than half of the patients assessed were not eligible for enrollment in any of 15 major randomized controlled trials in critical care, most often due to the absence of the specific clinical condition of study. The majority of patients who met criteria for a randomized controlled trial did so on the first day of ICU admission.
High‐Impact Sulfur Compounds: Constitutional and Configurational Assignment of Sulfur‐Containing Heterocycles (2008)

To unambiguously identify their structures and to evaluate their organoleptic properties, several constitutional und configurational isomers of dialkyl-tetrathianes and dialkyl-pentathiepanes were synthesized by two different synthetic protocols, and separated by preparative gas chromatography. Raman and NMR spectroscopy were used to differentiate between the constitutional 3,6-dialkyl-1,2,4,5-tetrathiane and the 4,6-dialkyl-1,2,3,5-tetrathiane isomers. Furthermore, cis- and trans-isomers of 3,6-dialkyl-1,2,4,5-tetrathianes were distinguished by temperature-dependent NMR experiments. Static, quantum-chemical simulations of the NMR spectra for these cis- and trans-isomers were calculated in the gas layer in order to confirm our experimental assignments. In addition, the assignment of 4,7-alkyl-1,2,3,5,6-pentathiepanes were deducted from their Raman spectra. Dialkyl-tetrathianes and dialkyl-pentathiepanes are interesting components to be used in flavor applications due to their unique olfactory impact and facets.
Exploring the dynamics of collective cognition using a computational model of cognitive dissonance (2013)

The socially-distributed nature of cognitive processing in a variety of organizational settings means that there is increasing scientific interest in the factors that affect collective cognition. In military coalitions, for example, there is a need to understand how factors such as communication network topology, trust, cultural differences and the potential for miscommunication affects the ability of distributed teams to generate high quality plans, to formulate effective decisions and to develop shared situation awareness. The current paper presents a computational model and associated simulation capability for performing in silico experimental analyses of collective sensemaking. This model can be used in combination with the results of human experimental studies in order to improve our understanding of the factors that influence collective sensemaking processes.
Effect of the Recording Material Shrinkage on Holographic Reconstructed Image and Compensation Method by Simulation (2008)

We derive the formula for intensity distribution of a holographic reconstructed image related to the effect of the recording material shrinkage for an off-axis holographic storage system with a plane wave reference beam using the Born approximation method. It is shown that even under the Bragg condition, the intensity across the reconstructed image decreases significantly when the angle between write reference beam and object beam becomes large. We also introduce a simple method to compensate for the effect of the recording material shrinkage by shifting the read reference beam angle.
SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes (2009)

Spliceosomal small nuclear ribonucleoproteins (snRNPs) in trypanosomes contain either the canonical heptameric Sm ring (U1, U5, spliced leader snRNPs), or variant Sm cores with snRNA-specific Sm subunits (U2, U4 snRNPs). Searching for specificity factors, we identified SMN and Gemin2 proteins that are highly divergent from known orthologs. SMN is splicing-essential in trypanosomes and nuclear-localized, suggesting that Sm core assembly in trypanosomes is nuclear. We demonstrate in vitro that SMN is sufficient to confer specificity of canonical Sm core assembly and to discriminate against binding to nonspecific RNA and to U2 and U4 snRNAs. SMN interacts transiently with the SmD3B subcomplex, contacting specifically SmB. SMN remains associated throughout the assembly of the Sm heteroheptamer and dissociates only when a functional Sm site is incorporated. These data establish a novel role of SMN, mediating snRNP specificity in Sm core assembly, and yield new biochemical insight into the mechanism of SMN activity.
A method of analysis for interleaved Reed-Solomon coding with erasure decoding on burst error channels (1993)

A practical definition of an erasure is presented and leads to new expressions for correct and incorrect decoding probabilities for Reed-Solomon codes, assuming an incomplete decoder. The main benefit of this approach is that, in contrast with the usual approach, one is able to analytically demonstrate the performance improvement provided by errors-and-erasures decoding relative to errors-only decoding. A technique is presented for evaluating the performance of Reed-Solomon codes for both types of decoding on an interleaved burst error channel such as is seen in digital magnetic tape recording. Several illustrative examples are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Liquid Manipulation Lithography to Fabricate a Multifunctional Microarray of Organosilanes on an Oxide Surface under Ambient Conditions (2008)

Abstract A novel method to produce a multifunctional microarray in which different types of self‐assembled monolayers (SAMs) are positioned on predefined surface sites on an oxide‐covered silicon substrate is described. To achieve this, a liquid‐transportation system called “liquid manipulation lithography” (LML) is developed. This system allows the delivery of different varieties of molecular inks, trialkoxysilanes, onto each predefined surface position of the given substrate even under ambient conditions. Under optimum conditions, the transferred trialkoxysilane inks first form one‐molecule‐thick microstructures at each surface position through the hydrolysis of the reactive silanes with surface water adsorbed on the substrate, followed by a condensation reaction. Three types of trialkoxysilanes with long alkyl‐chains, specifically triethoxysilylundecanal (TESUD), N ‐(6‐aminohexyl)‐3‐aminopropyltrimethoxysilane (AHAPS), and octadecyltrimethoxysilane (OTS), are used as model molecular inks due to their high‐end group‐functionalities in biological and electronic applications. The precise positioning of the ink with sub‐micrometer edge resolution is performed by carefully controlling a femtoliter‐scale liquid‐injection micromanipulator under a microscope. To ensure that the prepared SAM microarray is available for parallel analysis of biomolecular interactions, the area‐selective immobilization of a protein molecule is explored. Successful observation of the area‐selective biomolecular attachment confirmed a high industrial potential for the method as a lithography‐free process for the miniaturization of a multifunctional SAM array on an oxide substrate.
Low pressure plasmas for fuel cell design. Plasmas create a new path for future fuel cell designs (2007)

International audience
Sertoli cells and testicular differentiation in the rat fetus (1991)

The fetal testis is not merely a precursor of the adult organ: it is indeed an endocrine gland whose function is the masculinization of the fetus. It differs physiologically and morphologically from the adult testis. In this paper, the first stages of testicular differentiation in the rat are described, with special emphasis on the ultrastructural aspects. At the stage of 13.5 days after fertilization, the first Sertoli cells differentiate; they are characterized by a voluminous and little electron dense cytoplasm, a well-developed RER formed by vesicles and short cisternae filled with a flocculent material. Progressively, they polarize and adhere to one another by adherens-like junctions and cytoplasmic interdigitations to form the differentiating seminiferous cords. In the basal part of the Sertoli cells, a mat of microfilaments differentiates under the plasmalemma, while cytoplasmic blebs protruding in the extracellular space tend to disappear. A continuous basal lamina delineating the seminiferous cords begins to appear on day 14.5 and becomes widespread on day 15.5. These observations, when compared with other data from the literature, emphasize the fact that the differentiation of the Sertoli cells is the first morphological event during testicular differentiation. A possible role of the Sertoli cells in the subsequent organogenesis of the testis is suggested.
Development of Transient Stability Controller System (TSC) Based on On-Line Stability Calculation (1995)

A new Transient Stability Controller system (TSC) based on on-line transient stability calculation has been developed. The TSC system prevents the power system from wide-area blackout by shedding generators optimally when a serious fault occurs. This system consists of a central processing unit(TSC-P), and four local units for fault detection(TSC-C), and seventeen units for generator shedding(TSC-T). The TSC-P selects optimal generators to be shed for stabilization based on on-line transient stability calculation for contingencies at 500kV lines and buses every five minutes. The results are transmitted to the TSC-Cs periodically. Should any fault occur, only one TSC-C will detect the fault occurrence and send control signals to the TSC-Ts which actually generate shedding signals. To realize the TSC system, essential are fast stability evaluation method for a large number of contingencies and effective selection method of optimal generators to be shed for stabilization. This paper presents total algorithms applied in the TSC-P, the results of algorithm verification tests using a prototype system combined with a large-scale analog simulator, and the characteristics of the actual system.
Inner Shelf Benthic Foraminifera of the South China Sea, East Coast Peninsular Malaysia (2019)

Abstract The distributional patterns of modern benthic foraminifera from the inner shelf of the southern South China Sea, off the east coast of peninsular Malaysia, are documented for the first time. The study area from Tanjung Sedili, Johor in the south to Marang, Terengganu, in the north was selected for a sand-resource study by the Minerals and Geoscience Department, Malaysia in 1993. Twenty-four surface sediment samples from &lt;50 m water depth contained 266 foraminiferal species belonging to 6 orders, 49 families, and 117 genera, including 32 agglutinated, 130 calcareous hyaline, and 104 calcareous porcelaneous species. Two biofacies were distinguished by cluster analysis. Biofacies A was characterized by high relative abundance of Amphistegina papillosa and few other larger benthic foraminiferal (LBF) taxa in sandier sediments. Biofacies B was characterized by Pseudorotalia schroeteriana and other small rotaliids that were found in muddy sediments. The following features of foraminiferal assemblages and sediments reflect the strong fluvial/terrestrial influence on this tropical shelf environment: the overall moderate foraminiferal diversity, dominance of rotaliids over miliolids, overall dominance of smaller foraminiferal assemblages by Elphidium crispum, the limited diversity of LBF, the limited abundance of A. lessonii and the dominance of LBF assemblages by A. papillosa at relatively shallow depths. These features indicate at least intermittently turbid waters with limited light penetration and the dominance of the shelf sediments by siliciclastics, with mean percent carbonates &lt;35%.
Systematic or Stochastic Optimisation for Recognition, That is the Question! (1996)

Image object recognition using object models within an image search space is conventionally performed using a systematic or exhaustive search on a sequential xy grid at all pixel positions. Such a search is extremely slow and many speed up methods for exhaustive searches have been investigated by the authors and others. In this paper, we compare systematic search methods with a non-systematic method that was made by applying stochastic or random search methods for image objects. Stochastic search methods are an established method in numerical optimisation. The authors have now applied them to object recognition and have given some results in a previous paper. Important questions regarding stochastic search methods are: (I) when to select them over systematic search methods and (2) when to terminate the search. Our results show that this class of search converges quickly provided suitable scaling is made in the short range searches.
The Design Of The Central-Axis Reflector (ZAS) (1989)

The central-axis reflector (LAS) , the design principle which is pre-sented below is a segmented-mirror telescope.The inventions relate main-ly to the optical system and to the tracking apparatus. A large number of small individual mirror bodies , ground off-axis (hexagonal/polygonal) produce one primary mirror with closed circular aperture when joined together. The overall design of the tracking apparatus results directly-and thus without unnecessary adornment- from the two planes of motion which have been reduced to a minimum but which are required for tracking of the telescope.
Response of a Parametrically Excited System to a Nonstationary Excitation (1995)

The response of a single-degree-of-freedom system to a nonstationary excitation is investigated by using the method of multiple scales as well as analog- and digital-computer simulations. The unexcited system has one focus and two saddle points. The system can be used to model rolling of ships in head or follower seas. The method of multiple scales is used to derive equations governing the modulation of the amplitude and phase of the response. The modulation equations are used to find the stationary solutions and their stability. The response to nonstationary excitations is found by integrating the original governing equation as well as the modulation equations. There is good agreement between the results of both approaches. For some frequency and amplitude sweeps, the nonstationary response found from integrating the original governing equation exhibits behaviors that are analogous to symmetry-breaking bifurcations, period-doubling bi furcations, chaos, and unboundedness present in the stationary case. The maximum response amplitude and the excitation amplitude or frequency at which the response becomes unbounded are found as functions of the sweep rate. The results of the digital-computer simulations are verified with an analog computer.
Stateful PCE for SR-MPLS Inter-domain (2019)

This document proposes a solution to perform the Segment Routing with
MPLS data plane (SR-MPLS) inter-domain path computation and initiation
with stateful PCEs and the use of Path Segments.
Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine (1993)

Terfenadine is an H1-blocker that may have antiallergic properties. A study was carried out to examine the ability of terfenadine to inhibit the release of histamine and arachidonic-acid-derived mediators from human lung cells. Cells were dispersed from fresh human lung tissue obtained from four accident victims whose hearts were donated for transplantation and four lung cancer resections. Cells were dispersed by enzymatic digestion with type XIV protease and chymopapain, and this resulted in a cell population containing approximately 5% mast cells. The remaining cells were mainly macrophages. The cells were challenged with anti-IgE at a 1/1000 dilution. Cells were challenged without terfenadine and after a preincubation of 0.1, 1, and 10 mumol terfenadine. The release of PGD2 and LTC4/D4 was assessed with an EIA. Histamine was assayed by RIA with a monoclonal antibody against acylated histamine. A release of both eicosanoids and histamine was observed in all experiments. An inhibition of eicosanoids was observed at both 1 and 10 mumol terfenadine (median percentage of inhibition of PGD2: 38.00 +/- 15.65 and 56.00 +/- 13.12; median percentage of inhibition of LTC4/D4: 37.5 +/- 19.80 and 52.5 +/- 26.8). On the other hand, histamine release was not blocked by terfenadine. Terfenadine inhibits, in a dose-dependent manner, the release of eicosanoids after challenge of dispersed lung cells by anti-IgE, and this effect may have some clinical relevance.
An ultrasensitive sandwich-type electrochemical immunosensor based on δ-MnO2 and palladium nanoparticles covered natural halloysite nanotubes for the detection of hepatitis B surface antigen (2015)

An ultrasensitive sandwich-type immunosensor for the detection of HBsAg based on the multifunctional natural halloysite nanotube nanocomposites (Pd/δ-MnO<sub>2</sub>/HNTs).
The Utilization of Reduced Dimensional Representations of Molecular Structure for Rapid Molecular Similarity Calculations (1997)

The availability of two-dimensional representations of molecules which retain structural information permits the application of techniques from digital image processing to be applied to molecular similarity. Here three such approaches, invariant moments, radial integration and radial scanning, are investigated. They overcome the time consuming adjustment of the relative orientations of the molecules to be compared so as to optimize the similarity and can speed up the overall calculations by many orders of magnitude, hence offering a technique for dealing with the enormous numbers of compounds being generated by high throughput synthesis and combinatorial chemistry. These techniques are applied to the well-known set of steroids which are frequently used as a benchmark set for QSAR studies.
Supplementary figure legend from Everolimus Inhibits the Progression of Ductal Carcinoma <i>In Situ</i> to Invasive Breast Cancer Via Downregulation of MMP9 Expression (2023)

&lt;p&gt;Supplementary figure legend&lt;/p&gt;
First-trimester screening for early and late small-for-gestational-age neonates using maternal serum biochemistry, blood pressure and uterine artery Doppler (2013)

First-trimester screening predicts early SGA mainly because of its strong association with pre-eclampsia. Although prediction of late SGA was poorer, at a high false-positive rate it might be considered as part of a first-trimester strategy to select women requiring ultrasound assessment in the third trimester.
Program analysis and code generation in an APL/370 compiler (1986)

We have implemented an APL/370 compiler which accepts a subset of APL that includes most language features and a majority of APL primitive functions. It produces System/370 assembly code directly to be run independently of an interpreter. The compiler does not require variable declarations. Its front end, which is machine-independent, employs extensive type-shape analysis based on a type-shape calculus of the primitive functions and global dataflow analysis. Its back end does storage mapping, code generation for various primitive functions, and register management. For one-line functions, compiled code executes at 2–10 times the speed of the interpreter. On programs with many iterations, the execution time of the compiled code not only is dramatically better than that of interpretation, but is actually fairly close to that of FORTRAN. This removes the performance penalty of APL in computation-intensive applications.
T Cells Modulate Neutrophil-Dependent Acute Renal Failure during Endotoxemia (2005)

Sepsis still represents a leading cause of acute renal failure (ARF). Both lymphocytes and neutrophils (PMN) have been proposed as crucial mediators during sepsis. For further elucidation of the mechanisms of interactions between them, a murine model of LPS-induced ARF was used. In wild-type mice (WT), LPS administration led to a strong influx of PMN into the kidney (2.8-fold greater renal myeloperoxidase activity after 24 h) and to severe ARF (3.3-fold higher plasma creatinine concentrations after 24 h). By contrast, mice that were gene deficient for CD28 (CD28(-/-)), a co-stimulatory molecule for T cell activation, exhibited only minor renal dysfunction (50% protection compared with WT) and almost no PMN recruitment. When PMN(-) depleted, both WT and CD28(-/-) developed only mild ARF, similar to untreated CD28(-/-). Flow cytometry demonstrated that CD28 was vastly expressed on CD3(+) cells but not on PMN. Injecting wild-type CD3(+) cells into CD28(-/-) before LPS injection abolished the protection seen before. At baseline, both WT and CD28(-/-) displayed similar plasma concentrations of keratinocyte-derived chemokine (KC), a growth-related oncogene 1 gene product and PMN-specific chemokine. As opposed to WT, CD28(-/-) showed a greatly attenuated increase in plasma KC 4 h after LPS (2.5- versus 138.5-fold over controls, respectively). Moreover, CD28(-/-) showed less intense upregulation of renal growth-related oncogene 1 mRNA expression. Immunohistochemistry revealed considerable PMN but no T cell infiltrates in the kidney after LPS injection. In a PMN-dependent model of endotoxemic ARF, T cells, via the CD28 pathway, modulate kidney function and renal PMN recruitment. The effect on PMN is a remote one and presumably due to altered expression of PMN-specific chemokines.
CMOS phase frequency detector for high speed applications (2009)

A simple new phase frequency detector design is presented in this paper. Falling-Edge PFD uses only 12 transistors and preserves the main characteristics of the conventional PFD. It is implemented using Silterra 0.18 ¿m CMOS Process. It consumes 6.6 ¿W when operating at 50 MHz clock frequency with 1.8 V voltage supply. It has free dead zone and operates up to 2.5 GHz. It can be used in high speed and low power consumption applications. A single ended switch at source charge pump is presented as well. It is compatible with the FE-PFD outputs characteristics.
A New Silicon Integrated Head For High Density Magnetic Tape Recording (1994)

A new silicon integrated magnetic head with a very narrow track width has been achieved. A collective process has been used to carry out a vertical gap fabrication which avoids a glass bonding in the gap area, and allows an integrated coil elaboration. Wear behaviour and frequency dependance for reproduced output level have been investigated.