gebhart/patrepeval huggingface dataset:
Fundamental studies of the energetics and dynamics of ligand dissociation and exchange processes at transition-metal centers in the gas phase: Mn(CO)x+, x = 1-6 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFundamental studies of the energetics and dynamics of ligand dissociation and exchange processes at transition-metal centers in the gas phase: Mn(CO)x+, x = 1-6David V. Dearden, Kathleen Hayashibara, J. L. Beauchamp, Nicholas J. Kirchner, Petra A. M. Van Koppen, and Michael T. BowersCite this: J. Am. Chem. Soc. 1989, 111, 7, 2401–2409Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00189a005https://doi.org/10.1021/ja00189a005research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Genetic Basis for Bacterial Mercury Methylation (2013)

Methylmercury is a potent neurotoxin produced in natural environments from inorganic mercury by anaerobic bacteria. However, until now the genes and proteins involved have remained unidentified. Here, we report a two-gene cluster, hgcA and hgcB, required for mercury methylation by Desulfovibrio desulfuricans ND132 and Geobacter sulfurreducens PCA. In either bacterium, deletion of hgcA, hgcB, or both genes abolishes mercury methylation. The genes encode a putative corrinoid protein, HgcA, and a 2[4Fe-4S] ferredoxin, HgcB, consistent with roles as a methyl carrier and an electron donor required for corrinoid cofactor reduction, respectively. Among bacteria and archaea with sequenced genomes, gene orthologs are present in confirmed methylators but absent in nonmethylators, suggesting a common mercury methylation pathway in all methylating bacteria and archaea sequenced to date.
State of Charge Estimation of Lithium-ion Battery based on Minimum Error Entropy Square Root Cubature Kalman Filter (2022)

To account for the impulsive non-Gaussian noises, a minimum error entropy square root cubature Kalman filter (MEE-SRCKF) is proposed to estimate the state of charge (SOC) of lithium-ion batteries. It adopts the robust minimum error entropy (MEE) criterion as the optimization criterion, instead of the MMSE or maximum correntropy criterion (MCC). And then the square root cubature Kalman filter (SRCKF) is used to deal with the nonlinearity. The performance of the proposed algorithm is validated by a pulsed discharge test and an urban dynamometer driving schedule (UDDS) test. Experimental results demonstrate that the proposed approach has significantly improved the SOC estimation accuracy of the lithium-ion battery under non-Gaussian measurement noise compared with the SRCKF algorithm. In addition, given different initial SOC values, MEE-SRCKF algorithm also converges rapidly to its true value.
The Role of CT in the Diagnosis of Laryngeal Carcinoma (1985)

A detailed mapping of tumors of the larynx and their deep extent is necessary for their correct classification and for selection of a safe and proper treatment for the patient.
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes (2015)

We present a capture-based approach for bisulfite-converted DNA that allows interrogation of pre-defined genomic locations, allowing quantitative and qualitative assessments of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) at CG dinucleotides and in non-CG contexts (CHG, CHH) in mammalian and plant genomes. We show the technique works robustly and reproducibly using as little as 500 ng of starting DNA, with results correlating well with whole genome bisulfite sequencing data, and demonstrate that human DNA can be tested in samples contaminated with microbial DNA. This targeting approach will allow cell type-specific designs to maximize the value of 5mC and 5hmC sequencing.
Particle monitoring and control in vacuum processing equipment (1989)

Particle contamination during vacuum processes has emerged as the largest single source of yield loss in VLSI manufacturing. While a number of tools have been available to help understand the sources and nature of this contamination, only recently has it been possible to monitor free particle levels within vacuum equipment in real‐time. As a result, a better picture is available of how particle contamination can affect a variety of processes.This paper reviews some of the work that has been done to monitor particles in vacuum loadlocks and in processes such as etching, sputtering and ion implantation. The aim has been to make free particles in vacuum equipment a measurable process parameter. Achieving this allows particles to be controlled using statistical process control.It will be shown that free particle levels in load locks correlate to wafer surface counts, device yield and process conditions, but that these levels are considerable higher during production than when dummy wafers are run to qualify a system. It will also be shown how real‐time free particle monitoring can be used to monitor and control cleaning cycles, how major episodic events can be detected, and how data can be gathered in a format suitable for statistical process control.
Direct Problems and Inverse Problems in Biometric Systems (2013)

The article purpose is to describe the two sides of biometrics technologies, direct problems and inverse problems. The advance that we face today in field of Information Technology makes Information Security an inseparable part. The authentication has a huge role when we deal about security. The problems that can appear in implementing and developing biometrics systems is raising many problems, and one of the goal of this article is to focus on direct and inverse problems which is a new and challenging branch in biometrics technologies.
Supplementary Figure 3 from δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion (2023)

&lt;p&gt;Bevacizumab treatment led to increase in invasive and high expression of Î'-catenin. Silencing of Î'-catenin decreased bevacizumab-induced glioma invasion and Î'-catenin expression. Overexpressed Î'-catenin tumor cells showed more invasiveness and expressed high level ofÎ'-catenin protein in the tumor area in vivo.&lt;/p&gt;
Identification of Secreted Factors with a Role in Hematopoietic Stem and Progenitor Cell Engraftment in the Developing Zebrafish (2014)

Abstract The hematopoietic microenvironment regulates the behavior of hematopoietic stem and progenitor cells (HSPC) throughout vertebrate development. We sought to identify secreted factors that may play a role in HSPC engraftment in the caudal hematopoietic territory (CHT), an endothelial cell-rich vascular plexus that serves as the primary site of hematopoiesis in the developing zebrafish from 3-6 days post fertilization (dpf). We hypothesized that such factors would be highly expressed in endothelial cells relative to hematopoietic stem cells (HSCs). To identify these factors, endothelial cells and HSCs were purified from 3 dpf Flk1:mcherry; Runx1:GFP double transgenic zebrafish embryos and gene expression profiling was performed by microarray analysis. Gene set enrichment analysis of these data showed that zebrafish chemokines, cytokines, TGF-β, TNF, Notch and non-canonical WNT family members were enriched in the endothelial cell fraction with a nominal P ≤ 0.2. Genes from the leading edge of these gene sets were then used as candidates for gain-of-function testing. Coding sequences from candidate genes were cloned downstream of the zebrafish HSP70l promoter and microinjected into wildtype zebrafish embryos at the single-cell stage. Gene expression was induced in F0 transgenic animals by heat shock at 36 and 48 hours post fertilization. HSPC numbers were assayed by performing whole-mount in situ hybridization to identify runx1- and cmyb-expressing cells at 3 dpf. WNT5A was found to enhance HSPC numbers in this assay (P = 0.00046). We conclude non-canonical WNT family members, in particular WNT5A, regulate HSPC engraftment in the developing zebrafish. Disclosures Tamplin: Boston Children's Hospital: Patents &amp; Royalties. Zon:FATE Therapeutics, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Other; Scholar Rock: Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Other; Stemgent: Equity Ownership, Membership on an entity's Board of Directors or advisory committees.
Direct Determination of Glycidyl Esters of Fatty Acids in Vegetable Oils by LC–MS (2011)

An LC-MS method using a single quadrupole mass spectrometer was developed for direct analysis of glycidyl esters of fatty acids in vegetable oils. Without any sample clean-up, this method provided acceptable recovery of seven glycidyl esters, comparable results to a previously-published method utilizing two solid-phase extraction steps, and consistent detection parameters after greater than 200 injections without any cleaning operations performed. This method could readily be implemented as a screening assay for glycidyl esters in most oil laboratories.
A Pragmatic Load Detecting System Based on Uncertainty Evaluation for Construction Manipulator (2012)

A pragmatic framework for detecting (identifying the on-off state of) the external force applied to a construction manipulator (front load) by using a hydraulic sensor is proposed. Such a load detecting system requires high accuracy and robustness considering the uncertainty in pressure-based force measurement. The proposed framework first identifies the dominant error force component, including self-weight and driving force, using theoretical and experimental estimation and binarizes the analog cylinder external force. It then evaluates detection conditions to address indeterminate conditions such as stroke-end, singular posture, and impulsive or oscillatory force and redefines three-valued outputs such as on, off, or not determinate (ND). It finally outputs the front load decision by combining all the cylinder decisions to improve robustness through priority analysis. Experiments were conducted using an instrumented hydraulic arm. Results indicate that the proposed framework detects on, off, and ND outputs of the front load more accurately, robustly, and stably in various detection conditions.
Molecular Dynamic Simulation And Receptor-Based Pharmacophore Modeling On Human Renin For Discovery Of Novel Inhibitors (2013)

Hypertension is characterized with stress on the heart and blood vessels thus increasing the risk of heart attack and renal diseases. The Renin angiotensin system (RAS) plays a major role in blood pressure control. Renin is the enzyme that controls the RAS at the rate-limiting step. Our aim is to develop new drug-like leads which can inhibit renin and thereby emerge as therapeutics for hypertension. To achieve this, molecular dynamics (MD) simulation and receptor-based pharmacophore modeling were implemented, and three rennin-inhibitor complex structures were selected based on IC50 value and scaffolds of inhibitors. Three pharmacophore models were generated considering conformations induced by inhibitor. The compounds mapped to these models were selected and subjected to drug-like screening. The identified hits were docked into the active site of renin. Finally, hit1 satisfying the binding mode and interaction energy was selected as possible lead candidate to be used in novel renin inhibitors.
Multiple-valued Boolean minimization based on graph coloring (2003)

A method for the minimization of multiple-valued input Boolean functions is presented. It is based on the reduction of logic minimization problem to graph coloring, applied to the graph of incompatibility of implicants. In this approach, two NP-complete problems encountered in the minimization of Boolean functions, i.e. the generation of prime implicants and the covering problem, are reduced to a single, and better understood, graph coloring problem. A special type of implicants, called minimally split product implicants, is generated from an arbitrary set of input cubes that allow optimum results to be obtained. An important result of this method is that it is analytical, rather than heuristic, and gives more insight into a larger class of logic synthesis problems, such as input encoding and Boolean decomposition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Review article: the current management of acute liver failure (2009)

Acute liver failure remains a truly challenging condition to manage, and requires early recognition and transfer of patients to specialist centres providing intensive, multidisciplinary input and, in some cases, OLT.
History of flood fighting in the Kisosansen River Basin (2008)

The Isewan Typhoon caused considerable damage to the downstream regions of the Kisosansen River Basin on 26 th September 1959. It caused approximately 4,500 deaths in and around Nagoya City, the most industrial city in Japan. This study describes the history surrounding the major flood mitigation projects related to land use in the Kisosansen River Basin since 100 A.D. when paddy fields were first established on the alluvial plain. Land use of the area gradually evolved to cover the entire alluvial plain, developing from subsistence farming to modern sophisticated industry. This study shows that economic development in the both side plains of the river has been altered since the construction of the eastern side dike on the Kiso River. The Kisosansen River Basin, with a catchment area of 9,100 km 2 , is drained by the Kiso River, the Nagara River and the Ibi River. These rivers previously flew in the Nobi Plain as a single river, with successive floods producing a change in the main channel.
Identification of glucuronides as in vivo liver conjugates of seven cannabinoids and some of their hydroxy and acid metabolites. (1977)

Glucuronide conjugates of cannabidiol (CBD), 7-hydroxy-CBD, propyl-CBD, cannabinol (CBN), 7-hydroxy-CBN, CBN-7-oic acid, propyl CBN and cannabichromene have been identified as major metabolites of CBD, CBN and their propyl homologues and of cannabichromene in mouse liver. Trace amounts of the glucuronide conjugates of delta1- and delta1(6)-tetrahydrocannabinol (THC) were also detected. Identification was made by combined gas-liquid chromatographic and mass spectrometric studies of the trimethylsilyl (TMS), d9-TMS and methyl ester-TMS derivatives of the glucuronides and the TMS derivatives of the product of the reduction of the metabolites with lithium aluminium deuteride.
Enhancement of integrated photonic biosensing by magnetic controlled nano-particles (2018)

Integrated Mach-Zehnder interferometers, ring resonators, Bragg reflectors or simple waveguides are commonly used as photonic biosensing elements. They can be used for label-free detection relating the changes in the optical signal in realtime, as optical power or spectral response, to the presence and even the quantity of a target analyte on the surface of the photonic waveguide. The label-free method has advantages in term of sample preparation but it is more sensitive to spurious effects such as temperature and refractive index sample variation, biological noise, etc. Label methods can be more robust, more sensitive and able to manipulate the biological targets. In this work, we present an innovative labeled biosensing technique exploiting magnetic nano-beads for enhancement of sensitivity over integrated optic microrings. A sandwich binding is exploited to bring the magnetic labels close to the surface of the optical waveguide and interact with the optical evanescent field. The proximity and the quantity of the magnetic nano-beads are seen as a shift in the resonance of the microring. Detection of antibodies permits to reach a high level of sensitivity, down to 8 pM with a high confidence level. The sizes of the nano-beads are 50 to 250 nm. Furthermore, time-varying magnetic fields permit to manipulate the beads and even induce specific signals on the detected light to easy the processing and provide a reliable identification of the presence of the desired analyte. Multiple analytes detection is also possible.
A prospective study of interferon therapy modified by pre‐treatment viral load in cirrhotic patients (2000)

Sustained response was scarcely achieved in cirrhotic patients with high viral loads even after a 12-month course of intensive IFN therapy. This result indicates that there is a certain cut-off level of HCV RNA load which can not be eradicated.
Virtual memory window for application-specific reconfigurable coprocessors (2006)

The complexity of hardware/software (HW/SW) interfacing and the lack of portability across different platforms, restrain the widespread use of reconfigurable accelerators and limit the designer productivity. Furthermore, communication between SW and HW parts of codesigned applications are typically exposed to SW programmers and HW designers. In this work, we introduce a virtualization layer that allows reconfigurable application-specific coprocessors to access the user-space virtual memory and share the memory address space with user applications. The layer, consisting of an operating system (OS) extension and a HW component, shifts the burden of moving data between processor and coprocessor from the programmer to the OS, lowers the complexity of interfacing, and hides physical details of the system. Not only does the virtualization layer enhance programming abstraction and portability, but it also performs runtime optimizations: by predicting future memory accesses and speculatively prefetching data, the virtualization layer improves the coprocessor execution-applications achieve better performance without any user intervention. We use two different reconfigurable system-on-chip (SoC) running Linux and codesigned applications to prove the viability of our concept. The applications run faster than their SW versions, and the overhead due to the virtualisation is limited. Dynamic prefetching in the virtualisation layer further reduces the abstraction overhead
The LiaFSR System Regulates the Cell Envelope Stress Response inStreptococcus mutans (2009)

Maintaining cell envelope integrity is critical for bacterial survival, including bacteria living in a complex and dynamic environment such as the human oral cavity. Streptococcus mutans, a major etiological agent of dental caries, uses two-component signal transduction systems (TCSTSs) to monitor and respond to various environmental stimuli. Previous studies have shown that the LiaSR TCSTS in S. mutans regulates virulence traits such as acid tolerance and biofilm formation. Although not examined in streptococci, homologs of LiaSR are widely disseminated in Firmicutes and function as part of the cell envelope stress response network. We describe here liaSR and its upstream liaF gene in the cell envelope stress tolerance of S. mutans strain UA159. Transcriptional analysis established liaSR as part of the pentacistronic liaFSR-ppiB-pnpB operon. A survey of cell envelope antimicrobials revealed that mutants deficient in one or all of the liaFSR genes were susceptible to Lipid II cycle interfering antibiotics and to chemicals that perturbed the cell membrane integrity. These compounds induced liaR transcription in a concentration-dependent manner. Notably, under bacitracin stress conditions, the LiaFSR signaling system was shown to induce transcription of several genes involved in membrane protein synthesis, peptidoglycan biosynthesis, envelope chaperone/proteases, and transcriptional regulators. In the absence of an inducer such as bacitracin, LiaF repressed LiaR-regulated expression, whereas supplementing cultures with bacitracin resulted in derepression of liaSR. While LiaF appears to be an integral component of the LiaSR signaling cascade, taken collectively, we report a novel role for LiaFSR in sensing cell envelope stress and preserving envelope integrity in S. mutans.
Two‐Flux and Multiflux Matrix Models for Colored Surfaces (2015)

Abstract This chapter presents various extensions of the so‐called two‐flux models for prediction of reflectance and transmittance of diffusing media, that is, the Kubelka–Munk model, introduced in Fundamentals of Optics and Radiometry for Color Reproduction, and the extension of Kubelka–Munk for stacks of diffusing layers. A first matrix formulation of the Kubelka–Munk differential equations leads to a matrix framework based on transfer matrices, which can be extended to stacks of diffusing layers, stacks of nonscattering films, and stacks of scattering and nonscattering films as a generalization of the Williams–Clapper model for prediction of the reflectance of paper photographs, each of these configurations being illustrated through various examples. This chapter also exposes the limits of the two‐flux approach and shows that the matrix formalism extends in a straightforward manner to multiflux models, where the size of the matrices is increased.
Pyridine N ‐oxide and pyridine‐ d 5 N ‐oxide: an electrospray/tandem mass spectrometric study carried out at high mass resolution (2005)

A mass spectrometric study of pyridine N-oxide and pyridine-d5 N-oxide was carried out with a hybrid quadrupole/time-of-flight (TOF) mass spectrometer coupled with an electrospray (ES) source. In addition to the observation of protonated, sodiated, and proton-bound dimers of pyridine N-oxide and pyridine-d5 N-oxide, mass scans revealed the presence of several doubly-charged ion species. Doubly-charged ions of m/z 191 were identified as diprotonated tetramers of pyridine N-oxide; a structure has been proposed for the diprotonated tetramer and its energy relative to that of protonated pyridine N-oxide has been obtained from geometry optimizations. The principal ion species observed were subjected to collision-induced dissociation; accurate mass measurements were made of each fragment ion so as to determine its elemental composition. On the basis of mass spectrometric evidence, it is suggested that dissociation of pyridine N-oxide may occur during the ES process and the resulting fragments become embedded in doubly-charged ions. The proton affinity for both pyridine N-oxide and pyridine-d5 N-oxide was calculated; the difference between these proton affinities was compared with an experimentally determined difference between the proton affinities of pyridine N-oxide and pyridine-d5 N-oxide.
Sodium Tetrafluoroborate as a New and Highly Efficient Catalyst for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐Ones and Thiones (2007)

Abstract Sodium tetrafluoroborate (NaBF 4 ) is found to catalyze the three component condensation of an aldehyde, 1,3‐dicarbonyl compound and urea or thiourea to afford the corresponding 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones in high yields. This method is very useful for the synthesis of a wide range of 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones from aromatic, heterocyclic, α,β‐unsaturated aldehydes and aliphatic aldehydes.