gebhart/patrepeval huggingface dataset:
Engineering for the Customer: Combining Preference and Physical System Models. Part I—Theory (1995)

SUMMARY Engineering products for the customer is difficult. The criteria may be subjective, and often quality and cost are competing objectives which must be balanced. This paper proposes a model which structures the design process, and a methodology to engineer for customer preference. The model links design variables—tangible features of the design concept which can be manipulated by the designer—to multi-attribute value, a number indicating customer preference. Intermediate transfer functions within the model link design variables to system responses, and link specific system responses to value. Thus, customer expectations can be met more effectively, as design variables are related to customer preference in a quantitative way. An iterative design improvement method is considered in which a current design and a new design are compared. The comparison is made by mapping the designs into customer value space, and applying a measure of overall customer preference which considers both cost and a quality attribute.
Characterization of oxidase(s) associated with the sex pheromone gland in Manduca sexta (L.) females (1995)

Abstract An oxidase that converts primary aliphatic alcohols into aldehydes was discovered in the cuticle of the sex pheromone gland and in the papillae anales on the tip of the abdomen of Manduca sexta females. Oxidase activity was not found in the epidermal cells of the pheromone gland where fatty acid precursors of the pheromonal aldehydes are found. This oxidase requires oxygen and water to function and appears to have a rather broad substrate specificity. The activity of the oxidase is reduced by the application of piperonyl butoxide, which also interferes with the PBAN induced production of the natural pheromone aldehydes. However, endogenous alcohols cannot be found in the pheromone gland. Thus, it is not yet clear whether or not the oxidase is involved in the terminal step of biosynthesis of the pheromone aldehydes in M. sexta females. © Wiley‐Liss, Inc. This article is a U.S. Government work and, a such, is in the public domain in the United States of America.
A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms (2021)

Platinum-based drugs are a mainstay of cancer chemotherapy. However, their mutagenic effect can increase tumour heterogeneity, contribute to the evolution of treatment resistance and also induce secondary malignancies. We coupled whole genome sequencing with phenotypic investigations on two cell line models to compare the magnitude and examine the mechanism of mutagenicity of cisplatin, carboplatin and oxaliplatin. Cisplatin induced significantly more base substitution mutations than carboplatin or oxaliplatin when used at equitoxic concentrations on human TK6 or chicken DT40 cells, and also induced the highest number of short insertions and deletions. The analysis of base substitution spectra revealed that all three tested platinum drugs elicit both a direct mutagenic effect at purine dinucleotides, and an indirect effect of accelerating endogenous mutagenic processes, whereas the direct mutagenic effect appeared to correlate with the level of DNA damage caused as assessed through histone H2AX phosphorylation and single-cell agarose gel electrophoresis, the indirect mutagenic effects were equal. The different mutagenicity and DNA-damaging effect of equitoxic platinum drug treatments suggest that DNA damage independent mechanisms significantly contribute to their cytotoxicity. Thus, the comparatively high mutagenicity of cisplatin should be taken into account in the design of chemotherapeutic regimens.
Essential Oil Extraction, Chemical Analysis and Anti-Candida Activity of Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Ball—New Approaches (2017)

A comprehensive study on essential oils extracted from different Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Ball samples from Tarquinia (Italy) is reported. In this study, the 24-h steam distillation procedure for essential oil preparation, in terms of different harvesting and extraction times, was applied. The Gas chromatography-mass spectrometry (GC/MS) analysis showed that C. nepeta (L.) Savi subsp. glandulosa (Req.) Ball essential oils from Tarquinia belong to the pulegone-rich chemotype. The analysis of 44 samples revealed that along with pulegone, some other chemicals may participate in exerting the related antifungal activity. The results indicated that for higher activity, the essential oils should be produced with at least a 6-h steam distillation process. Even though it is not so dependent on the period of harvesting, it could be recommended not to harvest the plant in the fruiting stage, since no significant antifungal effect was shown. The maximum essential oil yield was obtained in August, with the highest pulegone percentage. To obtain the oil with a higher content of menthone, September and October should be considered as the optimal periods. Regarding the extraction duration, vegetative stage material gives the oil in the first 3 h, while material from the reproductive phase should be extracted at least at 6 or even 12 h.
Categories of Auditory Performance. (1995)

Categories of Auditory Performance (CAP) is an index consisting of eight performance categories arranged in order of increasing difficulty. It has been used to categorize 53 children who had been deafened below the age of 3. The children were assessed by means of the CAP before implantation, and over the following 3 years. Before implantation, only 2 of the children showed awareness of environmental sounds; immediately after initial tuning, all children showed awareness of environmental sounds, and 50% showed awareness of speech sounds. Their auditory receptive abilities gradually developed over the 3-year period, and by the 3-year assessment interval, 80% were understanding phrases without lipreading, and 40% were understanding conversation. Using these data, we predict that 90% of such children will understand conversation without lipreading 5 years after initial tuning.
Determination of copper in alloys by fast neutron activation (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of copper in alloys by fast neutron activationP. J. Daly , K. J. Hofstetter , and F. Schmidt-Bleek Cite this: J. Chem. Educ. 1967, 44, 7, 412Publication Date (Print):July 1, 1967Publication History Received3 August 2009Published online1 July 1967Published inissue 1 July 1967https://doi.org/10.1021/ed044p412RIGHTS & PERMISSIONSArticle Views101Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Phthalate Exposure May Affect Girl Puberty Via Stimulation of Kisspeptin-54 Secretion (2010)

O-30C7-4 Background/Aims: Central precocious puberty (CPP) is a complex problem with hypothalamic-pituitary-gonadal (HPG) axis for children development. This research is aimed to investigate the relationship and effect mechanism between phthalate exposure and girl puberty. Methods: This case-control study was conducted from 2007 to 2009. Twenty-six CPP girls were recruited from the polyclinic of Pediatric Endocrinology in National Cheng Kung University Hospital, and 11 normal and similar age ranged girls were recruited as control group from elementary school. Informed consents were obtained from all participants and their parents. Basic clinical diagnostic, luteinizing hormone, follicle-stimulating hormone, estradiol, 7 urinary phthalate metabolites, and kisspeptin-54 levels were evaluated in each participant. The concentration of kisspeptin-54 was measured using kisspeptin-54 radioimmunoassay kit. Seven urinary phthalate metabolites including MMP, MEP, MBP, MBzP, MEHP, MEOHP, and MEHHP were analyzed by LC-MS/MS. Results: Kisspeptin-54 levels of CPP girls were significantly higher than those of control group (2.23 pmol/L V.S. 1.95 pmol/L; P = 0.01). We further divided CPP girls into 2 groups: treatment with Leupline and nontreatment with Leupline. The results showed a significantly increasing trend of kisspeptin-54 among 3 groups (trend test, P = 0.003). Levels of urinary phthalate metabolites also revealed a significant difference (P < 0.05) among 3 groups on MMP, MBP, MBzP, MEOHP, MEHHP. Significantly positive correlation between kisspeptin-54 secretion and urinary MBP levels in girls were found (R2 = 0.288; P = 0.001). Conclusion: In this study, we found MBP may affect puberty onset in girls by stimulating kisspeptin-54 secretion. Future researches are needed to elucidate the mechanism of action and to investigate whether any other factors related to DBP exposure alter the kisspeptin-54 secretion.
Spectral Methods In Fluid Dynamics (1987)

Chapters 4 to 8 for the algorithms and Chapters 9 to 12 for the analysis.Nevertheless, and despite the particular research interests of
Unbiased Recursive Partitioning to Stratify Patients with Acute Traumatic Spinal Cord Injuries: External Validity in an Observational Cohort Study (2019)

Clinical trials of novel therapies for acute spinal cord injury (SCI) are challenging because variability in spontaneous neurologic recovery can make discerning actual treatment effects difficult. Unbiased Recursive Partitioning regression with Conditional Inference Trees (URP-CTREE) is a novel approach developed through analyses of a large European SCI database (European Multicenter Study about Spinal Cord Injury). URP-CTREE uses early neurologic impairment to predict achieved motor recovery, with potential to optimize clinical trial design by optimizing patient stratification and decreasing sample sizes. We performed external validation to determine how well a previously reported URP-CTREE model stratified patients into distinct homogeneous subgroups and predicted subsequent neurologic recovery in an independent cohort. We included patients with acute cervical SCI level C4-C6 from a prospective registry at a quaternary care center from 2004-2018 (<i>n</i> = 101) and applied the URP-CTREE model and evaluated Upper Extremity Motor Score (UEMS) recovery, considered correctly predicted when final UEMS scores were within a pre-specified threshold of 9 points from median; sensitivity analyses evaluated the effect of timing of baseline neurological examination. We included 101 patients, whose mean times from injury baseline and follow-up examinations were 6.1 days (standard deviation [SD] 17) and 235.0 days (SD 71), respectively. Median UEMS recovery was 7 points (interquartile range 2-12). One of the predictor variables was not statistically significant in our sample; one group did not fit progressively improving UEMS scores, and three of five groups had medians that were not significantly different from adjacent groups. Overall accuracy was 75%, but varied from 82% among participants whose examinations occurred at <12 h, to 64% at 12-24 h, and 58% at >24 h. A previous URP-CTREE model had limited ability to stratify an independent into homogeneous subgroups. Overall accuracy was promising, but may be sensitive to timing of baseline neurological examinations. Further evaluation of external validity in incomplete injuries, influence of timing of baseline examinations, and investigation of additional stratification strategies is warranted.
Solving low frequency EM-CKT problems using the PEEC method (2006)

The partial element equivalent circuit (PEEC) formulation is an integral equation based approach for the solution of combined electromagnetic and circuit (EM-CKT) problems. Traditional EM solvers like the electric field integral equation (EFIE) method suffer from numerical problems at low-frequencies arising from the decoupling of the charge and current basis functions. In this paper, the low frequency behavior of the PEEC matrix is investigated. Techniques leading to an excellent condition number throughout the entire frequency spectrum are discussed. Finally, these schemes are applied to remedy the low-frequency conditioning of the EFIE method.
Two distinct transcriptional activities of pea (Pisum sativum) chloroplasts share immunochemically related functional polypeptides (1992)

An RNA polymerase activity has been purified from pea (Pisum sativum) chloroplast extracts with a distinct transcriptional specificity for a chloroplast messenger gene. This activity (ms-RNA pol) differs from the pea RNA polymerase preparation reported by Sun, Shapiro, Wu & Tewari [(1986) Plant Mol. Biol. 6, 429-439], which specifically transcribes only the rRNA gene (rb-RNA pol). The specificity of transcription has been assessed by the synthesis in vitro of discrete transcripts of predicted sizes using cloned promoter regions of the chloroplast psbA and 16 S rRNA genes. The ms-RNA pol preparation, with polypeptides ranging in apparent molecular mass from 22 to 180 kDa, correctly initiates transcription from recombinant plasmids containing the psbA promoter and does not support 16 S rRNA promoter-directed transcription. The two activities differ also in their response to Mn2+ ions. To investigate whether the two transcriptional activities share common functional polypeptides, monoclonal antibodies were developed against the rb-RNA pol preparation. Three clones were selected on the basis of their ability to inhibit transcription in vitro of the 16 S rRNA gene by rb-RNA pol. The antibodies from these clones independently recognized three polypeptides with molecular masses of 27, 90 and 95 kDa on immunoblots. Antibodies cross-reacting with the 90 kDa polypeptide completely eliminated the specific retardation of an end-labelled 16 S rRNA promoter fragment in a mobility-shift assay, whereas the antibodies against the 95 kDa polypeptide resulted in the formation of a ternary complex (enzyme-DNA-antibody). The antibodies cross-reacting with the 27 kDa polypeptide, however, did not alter the mobility of the retarded DNA-enzyme complex on the gel. These antibodies also inhibited transcription in vitro of the psbA gene by ms-RNA pol and recognized polypeptides of identical molecular masses in the ms-RNA pol. These results show that the three polypeptides are functional components of the chloroplast transcriptional complex and appear to be involved in the transcription of both rRNA and mRNA genes. Transcriptional specificity is probably conferred by ancillary transcription factor(s) which remain to be identified.
Illumination invariant image indexing using moments and wavelets (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
A Review on Gel Polymer Electrolytes for Dye-Sensitized Solar Cells (2022)

Significant growth has been observed in the research domain of dye-sensitized solar cells (DSSCs) due to the simplicity in its manufacturing, low cost, and high-energy conversion efficiency. The electrolytes in DSSCs play an important role in determining the photovoltaic performance of the DSSCs, e.g., volatile liquid electrolytes suffer from poor thermal stability. Although low volatility liquid electrolytes and solid polymer electrolytes circumvent the stability issues, gel polymer electrolytes with high ionic conductivity and enduring stability are stimulating substitutes for liquid electrolytes in DSSC. In this review paper, the advantages of gel polymer electrolytes (GPEs) are discussed along with other types of electrolytes, e.g., solid polymer electrolytes and p-type semiconductor-based electrolytes. The benefits of incorporating ionic liquids into GPEs are highlighted in conjunction with the factors that affect the ionic conductivity of GPEs. The strategies on the improvement of the properties of DSSCs based on GPE are also presented.
Dynamic analysis and control of a zone-control induction heating system (2011)

This paper presents a quick and accurate power control method for a zone-control induction heating (ZCIH) system. The ZCIH system consists of multiple working coils connected to multiple H-bridge inverters. The system controls the amplitude and phase angle of each coil current to make the temperature distribution on the workpiece uniform. This paper proposes a new control method for the coil currents based on a circuit model using real and imaginary (Re-Im) current/voltage components. The method detects and controls the Re-Im components of the coil current instead of the current amplitude and phase angle. As a result, the proposed method enables decoupling control for the system, making the control for each working coil independent from the others. Experiments on a 6-zone ZCIH laboratory setup are conducted to verify the validity of the proposed method. It is clarified that the proposed method has a stable operation both in transient and steady states. The proposed system and control method enable system complexity reduction and control stability improvements.
ChemInform Abstract: MOLEKUEL‐PHOTOCHEMIE 24. MITT. STEREOSPEZIFISCHE PHOTORK. VON CYCLOBUTANONEN (1970)

Abstract Die aus den cis‐ bzw. trans‐Äthylenen (IV) und Keten (VIII) dargestellten cis‐ bzw. trans‐Cyclobutanone (I) reagieren in Methanol (II) beim Bestrahlen stereoselektiv zu den Äthem (III), (IV) und (VI) und zum Ester (V).
Interactions between intracellular Na+ levels and saxitoxin production in Cylindrospermopsis raciborskii T3 (2004)

Saxitoxin (STX) is the most potent representative among the paralytic shellfish poisoning (PSP) toxins, which are highly selective Na(+) channel-blocking alkaloids. This study investigated, in cultures of the cyanobacterium Cylindrospermopsis raciborskii T3, the effects of pH, salt, amiloride and lidocaine hydrochloride on total cellular levels of Na(+) and K(+) ions and STX accumulation. Both Na(+) levels and intracellular STX concentrations increased exponentially in response to rising alkalinity. NaCl inhibited cyanobacterial growth at a concentration of 10 mM. In comparison with osmotically stressed controls, however, NaCl promoted STX accumulation in a dose-dependent manner. A correlation was seen in the time-course of both total cellular Na(+) levels and intracellular STX for NaCl, amiloride and lidocaine exposure. The increase in cellular Na(+) induced by NaCl at 10 mM was coupled with a proportional accumulation of STX. The two Na(+) channel-blocking agents amiloride and lidocaine had opposing effects on both cellular Na(+) levels and STX accumulation. Amiloride at 1 mM reduced ion and toxin concentrations, while lidocaine at 1 micro M increased the total cellular Na(+) and STX levels. The effects of the channel-blockers were antagonistic and dependent on an alkaline pH. The results presented suggest that, in C. raciborskii T3, STX is responsive to cellular Na(+) levels. This may indicate that either STX metabolism or the toxin itself could be linked to the maintenance of cyanobacterial homeostasis. The results also enhance the understanding of STX production and the ecology of PSP toxin-producing cyanobacteria.
Study on optimization on fermentation conditions of producing citrulline by Enterococcus faecalis SK23.001 (2012)

A novel strain named SK23.001 was isolated from soil in Watermelon canopy and it was identified as Enterococcus faecalis. In order to enlarge the yield of citrulline,the fermentation of Enterococcus faecalis SK23.001 were optimalized. The optimal vaccination age and culture time was 12h and 16h,respectively. The optimum fermentation conditions by single -factor experiment and orthogonal experiment were determined:carbon source sucrose(0.5%),nitrogen source soya peptone and ammonium chloride,inoculation volume 3%,liquid medium volume 50mL/250mL,pH6.0,temperature 37℃ . The product was analyzed by HPLC and the 83.06g/L of citrulline transformed from 100g/L arginine could be attained after 6h.
Therapeutic Surfactants Modulate the Viability of Eosinophils and Induce Inflammatory Mediator Release (2009)

Therapeutic surfactants differ in their effects on eosinophil viability and the accompanying release of inflammatory mediators and chemotactic signals. Proinflammatory effects were most pronounced for the natural surfactant Curosurf.
Development of a solid-substrate room-temperature luminescence immunoassay (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a solid-substrate room-temperature luminescence immunoassayMark R. Glick and James D. WinefordnerCite this: Anal. Chem. 1988, 60, 18, 1982–1984Publication Date (Print):September 15, 1988Publication History Published online1 May 2002Published inissue 15 September 1988https://pubs.acs.org/doi/10.1021/ac00169a031https://doi.org/10.1021/ac00169a031research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TUP1, CPH1 and EFG1 Make Independent Contributions to Filamentation in Candida albicans (2000)

The common fungal pathogen, Candida albicans, can grow either as single cells or as filaments (hyphae), depending on environmental conditions. Several transcriptional regulators have been identified as having key roles in controlling filamentous growth, including the products of the TUP1, CPH1, and EFG1 genes. We show, through a set of single, double, and triple mutants, that these genes act in an additive fashion to control filamentous growth, suggesting that each gene represents a separate pathway of control. We also show that environmentally induced filamentous growth can occur even in the absence of all three of these genes, providing evidence for a fourth regulatory pathway. Expression of a collection of structural genes associated with filamentous growth, including HYR1, ECE1, HWP1, ALS1, and CHS2, was monitored in strains lacking each combination of TUP1, EFG1, and CPH1. Different patterns of expression were observed among these target genes, supporting the hypothesis that these three regulatory proteins engage in a network of individual connections to downstream genes and arguing against a model whereby the target genes are regulated through a central filamentous growth pathway. The results suggest the existence of several distinct types of filamentous forms of C. albicans, each dependent on a particular set of environmental conditions and each expressing a unique set of surface proteins.