gebhart/patrepeval huggingface dataset:
A Pilot Study of Blood-Based Methylation Markers Associated With Pancreatic Cancer (2022)

Over the past several decades in the United States, incidence of pancreatic cancer (PCa) has increased, with the 5-year survival rate remaining extremely low at 10.8%. Typically, PCa is diagnosed at an advanced stage, with the consequence that there is more tumor heterogeneity and increased probability that more cells are resistant to treatments. Risk factors for PCa can serve as a way to select a high-risk population and develop biomarkers to improve early detection and treatment. We focus on blood-based methylation as an approach to identify a marker set that can be obtained in a minimally invasive way (through peripheral blood) and could be applied to a high-risk subpopulation [those with recent onset type 2 diabetes (DM)]. Blood samples were collected from 30 patients, 15 had been diagnosed with PCa and 15 had been diagnosed with recent onset DM. HumanMethylationEPIC Beadchip (Illumina, CA, United States) was used to quantify methylation of approximately 850,000 methylation sites across the genome and to analyze methylation markers associated with PCa or DM or both. Exploratory analysis conducted to propose importance of top CpG (5'-C-phosphate-G-3') methylation site associated genes and visualized using boxplots. A methylation-based age predictor was also investigated for ability to distinguish disease groups from controls. No methylation markers were observed to be significantly associated with PCa or new onset diabetes compared with control the respective control groups. In our exploratory analysis, one methylation marker, CpG04969764, found in the Laminin Subunit Alpha 5 (<i>LAMA5</i>) gene region was observed in both PCa and DM Top 100 methylation marker sets. Modification of <i>LAMA5</i> methylation or <i>LAMA5</i> gene function may be a way to distinguish those recent DM cases with and without PCa, however, additional studies with larger sample sizes and different study types (e.g., cohort) will be needed to test this hypothesis.
Competitive Substitution Reactions at Extracoordinate Silicon during Asymmetric Hydrosilylation (2006)

Proline-derived small molecules were utilized as organic catalysts in the asymmetric hydrosilylation of ketones. Extracoordinate chiral hydrosilicates were generated in situ as shown by 29Si NMR. These active species reduce prochiral ketones enantioselectively in good yield but only moderate enantiomeric excess (up to 40%). The parameters affecting stereoselectivity have been studied in detail. By isolating some of the intermediates and performing a series of control reactions, the relative efficiency of alkoxy group exchange reactions and the ability of ketones to complex to extracoordinate hydrosilicates have been discovered to be critical factors. The proline catalyst is a poorer leaving group from the initial pentacoordinate product than the product of reduction, PhMeCHO-, which leads subsequently to several competitive hydrosilylation pathways.
Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques (2018)

In this study, we apply a battery of molecular similarity techniques to known inhibitors of kynurenine 3-monooxygenase (KMO), querying each against a repository of approved, experimental, nutraceutical, and illicit drugs. Four compounds are assayed against KMO. Subsequently, diclofenac (also known by the trade names Voltaren, Voltarol, Aclonac, and Cataflam) has been confirmed as a human KMO protein binder and inhibitor in cell lysate with low micromolar <i>K</i><sub>D</sub> and IC<sub>50</sub>, respectively, and low millimolar cellular IC<sub>50</sub>. Hit to drug hopping, as exemplified here for one of the most successful anti-inflammatory medicines ever invented, holds great promise for expansion into new disease areas and highlights the not-yet-fully-exploited potential of drug repurposing.
Prior exercise delays the onset of acidosis during incremental exercise (2007)

The effects of prior moderate- and prior heavy-intensity exercise on the subsequent metabolic response to incremental exercise were examined. Healthy, young adult subjects (n = 8) performed three randomized plantar-flexion exercise tests: 1) an incremental exercise test (approximately 0.6 W/min) to volitional fatigue (Ramp); 2) Ramp preceded by 6 min of moderate-intensity, constant-load exercise below the intracellular pH threshold (pHT; Mod-Ramp); and 3) Ramp preceded by 6 min of heavy-intensity, constant-load exercise above pHT (Hvy-Ramp); the constant-load and incremental exercise periods were separated by 6 min of rest. (31)P-magnetic resonance spectroscopy was used to continuously monitor intracellular pH, phosphocreatine concentration ([PCr]), and inorganic phosphate concentration ([P(i)]). No differences in exercise performance or the metabolic response to exercise were observed between Ramp and Mod-Ramp. However, compared with Ramp, a 14% (SD 10) increase (P < 0.01) in peak power output (PPO) was observed in Hvy-Ramp. The improved exercise performance in Hvy-Ramp was accompanied by a delayed (P = 0.01) onset of intracellular acidosis [Hvy-Ramp 60.4% PPO (SD 11.7) vs. Ramp 45.8% PPO (SD 9.4)] and a delayed (P < 0.01) onset of rapid increases in [P(i)]/[PCr] [Hvy-Ramp 61.5% PPO (SD 12.0) vs. Ramp 45.1% PPO (SD 9.1)]. In conclusion, prior heavy-intensity exercise delayed the onset of intracellular acidosis and enhanced exercise performance during a subsequent incremental exercise test.
A randomized phase 2 study evaluating optimal sequencing of sipuleucel-T (sip-T) and androgen deprivation therapy (ADT) in biochemically recurrent prostate cancer (BRPC): Preliminary clinical data. (2014)

5041 Background: Sip-T is an autologous cellular immunotherapy targeting prostatic acid phosphatase (PAP) that is approved by the FDA and EMA for the treatment of certain patients with asymptomatic/minimally symptomatic metastatic castration-resistant prostate cancer. The STAND trial (NCT01431391) evaluated optimal sequencing of sip-T and ADT in men with BRPC at high risk of developing metastases (PSA-DT ≤12 mos). Methods: Men (N=68) were randomized (1:1) to Arm 1: sip-T followed by ADT (2 wks after infusion 3) or Arm 2: ADT (3 mo lead-in) followed by sip-T. Men received 3 doses of sip-T and 12 mos of ADT (leuprolide). The primary endpoint was cellular immune response to target antigen (ELISPOT to PA2024). Secondary endpoints included humoral and cytokine responses, product parameters, clinical efficacy, and safety. Here we report preliminary clinical data and longer-term immune responses. Results: 65 men have been followed for ≥9 mos from last ADT injection: 10/32 (31.3%) in Arm 1 and 14/33 (42.4%) in Arm 2 achieved undetectable PSA (<0.02 ng/mL) and testosterone (T; <0.35 ng/mL) at 9 mos from last ADT injection; 4/65 men (6.2%) developed PSA progression (2 consecutive PSA measurements, 4 wks apart, ≥50% above nadir, >5ng/mL). In both arms, sip-T induced robust and prolonged immune responses to PA2024 and PAP (measured by T cell memory and ELISA antibody responses), although no significant differences have yet emerged between arms. There appear to be higher levels of serum cytokines in Arm 2 vs Arm 1, with a pattern suggesting a mixed TH1/TH2 cellular immune response; significant increases were seen in TH1 (IFNg, IL-12), TH2 (IL-4, IL-10, IL-13), and TH17 (IL-17) subsets (P<0.05). Conclusions: These data suggest that tumor-specific T cell responses and broad-based immune responses are augmented in both arms, and cytokine responses may be superior when sipuleucel-T is given after (rather than before) ADT initiation. In addition, augmented PA2024- and PAP-specific humoral responses have persisted for at least 12 mos, and are equally robust in both groups. Longer-term T cell responses and cytokine responses will be presented. Clinical trial information: NCT01431391.
Does the aldosterone: renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study (2007)

The numerous deleterious effects of hypertension dictate the need for a systematic approach for its treatment. In spite of various therapies, resistant hypertension is widely prevalent. Among various factors, primary aldosteronism is an important cause of resistant hypertension and is now more commonly recognised. More significantly, hypertensives with primary aldosteronism are also exposed to various other deleterious effects of excess aldosterone. Hence treating hypertension with specific aldosterone antagonists may be a better approach in this group of patients. It may lead on to better blood pressures with fewer medications.
REVIEWS Possessive pronouns and adjectives in ‘Garin le Loheren’ and ‘Gerbert de Metz’. By JANSEN-BECKLYDIA I.. New York: Ajax Offset Co. Inc.1961. x + 239 pp. (1962)

REVIEWS Get access Possessive pronouns and adjectives in ‘Garin le Loheren’ and ‘Gerbert de Metz’. By LYDIA I. JANSEN-BECK. New York: Ajax Offset Co. Inc. 1961. x + 239 pp. P. RICKARD P. RICKARD CAMBRIDGE Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XVI, Issue 1, January 1962, Page 85, https://doi.org/10.1093/fs/XVI.1.85 Published: 01 January 1962
Reactive Dyes Containing Hydrazino Group (1964)

ヒドラジノ基を有する二,三の染料を合成し,アクリル系繊維オーロン42に対する反応性染料としての適用性,色調,堅ロウ度などを調べた。本染料は,アミノ基を有するアゾ染料に塩化シアヌルを作用させ,さらにその活性塩素にヒドラジンヒドラートを反応させて合成するか,あるいは活性塩素を有するアントラキノン染料にヒドラジンヒドラートを反応させて合成した。またあるものはアミノ基を有するアントラキノン染料をジアゾ化,還元,ヒドラジノ化を行なった。二,三の市販のProcinyl染料,Remazol染料をヒドラジンヒドラートでヒドラジノ化した。これらの染料を用いてオーロン42をアセトン,エチルアルコールあるいは水中で染色を行なった。このほか,一部の染料についてはヒドラジノ化前の母体染料,ヒドラジンヒドラート,オーロン42をピリジン-水中で同時に反応,染色を行なった。未反応染料はアセトンあるいはアルコール抽出により除去した。一般にこれらの染料の染色性は非常に良好で,色調は黄,だいだい,赤,紫,青色系統である。堅ロウ度は洗タク,摩擦,日光とも一般にすぐれていた。染料-繊維間の共有結合生成に対する証拠は,染色物がアセトン,エチルアルコール,ピリジンの各溶剤中で抽出されないこと,およびジメチルホルムアミドに溶解させ,水で繊維を再沈殿させる操作をくりかえしても脱色しないことより確認した。
Polarized Luminescence from Oriented Molecular Materials (1999)

Organic electroluminescent devices that emit polarized light will be useful as backlights in conventional liquid-crystal displays. The necessary high polarization ratios require, in turn, highly aligned emitters. The various methods of orientation are discussed, together with the materials to which they are applicable. The Figure shows poly(phenylene vinylene), which is used as a luminescent guest molecule in an aligned host matrix.
RFID applications in hospitals - A case study for emergency department (2010)

Radio Frequency Identification (RFID) is a system that uses radio frequency to transmit identification wirelessly. Its functionality is much more powerful than bar code system, with which a contacting reader must be used to read the bar code. RFID, on the other hand, may read the information stored in a tag with a non-contact reader from a distance as far as tens of meters. Health care industry is highly valued throughout the world; applying the cutting edge technology in health care industry to improve patient health care has been the common goal pursued by the hospitals all over the world. The introduction of RFID as medical application is also being enthusiastically studied now. This Study finds the medical application of RFID application for the workflow of the most critical and the busiest unit in a hospital: the emergency department. The results of this Study may significantly increase the operation efficiency by improving the problems commonly experienced at the emergency room, such as congested queue for emergency treatment and sickbed space, understaffed medical personnel, and patient's leave without permission.
Expression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung (2000)

Congenital cystic adenomatoid malformation (CCAM) is an abnormality of branching morphogenesis of the lung. CCAM types 1, 2, and 3 exhibit a cellular composition that is different from that of CCAM type 4 when evaluated with bronchiolar and alveolar cell markers. Thyroid transcription factor 1 (TTF-1) regulates early lung development. To evaluate the potential role of TTF-1 in the development of CCAM, TTF-1 expression in CCAM was compared to that of fetal lungs at varying gestational ages. Twenty-three CCAM cases (17 type 1, two type 2, two type 3, and two type 4) and 11 fetal lungs (3 pseudoglandular, 4 canalicular, and 4 terminal sac stages) were analyzed using a rabbit polyclonal antiserum to rat TTF-1. Nuclear staining for TTF-1 was observed in ciliated and nonciliated cells of the bronchial and bronchiolar epithelia and in cells lining the distal air spaces by 12 weeks gestational age. By mid-gestation, proximal bronchial cells were TTF-1 negative, except for the basal cells, while TTF-1 staining was maintained in distal bronchiolar and alveolar cells. TTF-1 expression decreased in both bronchial, bronchiolar, and alveolar epithelia with advancing gestational age and cytodifferentiation. At term, TTF-1 expression persisted in a few bronchial and bronchiolar basal cells and in all alveolar type II cells, whereas type I cells were negative. In CCAM, TTF-1 was detected in the nuclei of epithelial cells lining the cysts. TTF-1 was expressed in a majority of the bronchiolar-like epithelial cells of the cysts in CCAM types 1, 2, and 3, where almost 100% of the cells were TTF-1 positive. In contrast, TTF-1 expression in the alveolar-like epithelium of CCAM type 4 cysts was restricted to type II cells and only 30%-60% of the lining cells were TTF-1 positive. These results support the hypothesis that CCAM types 1, 2, and 3 reflect abnormalities in lung morphogenesis and differentiation that are distinct from those for CCAM type 4. The role played by TTF-1 in the development of CCAM, if any, is not clear.
Surface shape measurement of mirrors in the form of rotation figures by using point diffraction interferometer (2016)

The paper deals with the use of a point diffraction interferometer (PDI) to study the surface shape of rotation figures. The relations are given for the correspondence of the coordinates on the surfaces of an ellipsoid, a paraboloid and a hyperboloid as well as on an interferogram. Using PDI and Zygo white-light interferometer (WLI), we experimentally investigated the surface shape of the grazing incidence ellipsoid with the multilayer reflective coating on a wavelength of 0.154 nm with the following parameters: length is 55 mm, half-axis are 6 and 235 mm. The results coincided with an accuracy of 73 nm (RMS) without taking into account the PDI lateral resolution, and with an accuracy of 50 nm (RMS) with taking it into account, which ensures the local angles measurement accuracy of the ellipsoid-shaped reflecting surface at a level of 3 μrad. We think that this difference may be attributed to the limited lateral resolution of PDI and errors of frames stitching of WLI; nevertheless, we do believe that the PDI measurement accuracy is in the range of sub-μrad.
Рыба вялено-провесная с улучшенными свойствами (2021)

A study of consumer preferences for dried and half-dried fish products among respondents regularly visiting large retail sites in the city of Murmansk was conducted. It was found that more than two-thirds of respondents prefer to purchase high-quality dried and half-dried fish products; the weight of the purchased package of this product does not have a significant value. Sensory evaluation of extracts of 16 phytoproducts was carried out and the following highest-scoring ones were selected: chamomile flowers; golden mustache; linden flowers and sand immortelle flowers. Experiments of salting Atlantic salmon fillets and cod fillets in a weak saline solution with phytoextract for 12-96 hours were carried out; the ratio of fish, saline solution and aqueous extract of phytoproducts were 1:1:0.01. The most acceptable duration of weak finished salting is established not to be exceeding 48 hours. Experiments on drying the semi-finished product were carried out to establish the quality characteristics and the maximum duration of dehydration of the dried and half-dried fish product. Studies of the dehydrated product carried out every 4 hours by the sensory evaluations, the content and activity of water Aw established the most acceptable drying time, not exceeding 36 hours. Studies of dried fish products were carried out every 20 days according to organoleptic, chemical and microbiological parameters during the 80-day storage period. An acceptable storage period (shelf life) at the temperature of 0 - minus 5  ? of dried and half-dried vacuumed fish has been established to be of two months. Based on the results of the experiments, the technical specifications and technological instructions for the production of a new type of dried and half-dried formed fish with improved properties were developed.
AMT Negates MUST (2007)

Editor: Although encouraging, the MUST Act is overshadowed by the Alternative Minimum Tax (AMT). (“‘Bad Debt’ Bill Aims to Cover Uncompensated Care,” EMN 2007;29[10]:1.) If a physician earns more than $75,000 annually, then the AMT would eliminate most if not all deductions provided for by the MUST Act. List all the deductions you'd like, but when you're earning what most emergency physicians do, the Alternative Minimum Tax will prevent such deductions from having any effect. Unless our representatives also create a waiver of some sort for the AMT, the MUST Act and any others like it are just gestures that really will do nothing to help alleviate the burden we're bearing. Jason Mount, MD Carrollton, GA
Oleum and Sulfuric Acid as Reaction Media: The Actinide Examples UO2(S2O7)‐lt (low temperature), UO2(S2O7)‐ht (high temperature), UO2(HSO4)2, An(SO4)2 (An = Th, U), Th4(HSO4)2(SO4)7 and Th(HSO4)2(SO4) (2011)

Abstract New uranium sulfates have been synthesised by the reaction of UO 2 (CH 3 COO) 2 · 2H 2 O with sulfuric acid/sulfur trioxide mixtures in sealed glass ampoules. Both polymorphs of the disulfate UO 2 (S 2 O 7 ) [low temperature (lt): triclinic, P $\bar {1}$ , Z = 2, a = 647.8(1) pm, b = 684.2(1) pm, c = 800.1(1) pm, α = 87.31(2)°, β = 78.37(2)°, γ = 75.34(2)°, V = 0.33605(9) nm 3 ; high temperature (ht): orthorhombic, Pca 2 1 , Z = 8, a = 1080.21(2) pm, b = 814.74(1) pm, c = 1655.63(3) pm, V = 1.45710(4) nm 3 ] and the hydrogensulfate UO 2 (HSO 4 ) 2 [monoclinic, P 2 1 / n , Z = 4, a = 779(3) pm, b = 815.39(3) pm, c = 1285.77(5) pm, β = 103.700(1)°, V = 0.79428(5) nm 3 ] contain hexavalent uranium in the form of the well‐known linear [UO 2 ] 2+ ion. The pentagonal bipyramidal coordination sphere around U is completed by disulfate and hydrogensulfate ions, which connect the uranyl groups to a three‐dimensional network. Reaction of uranyl acetate with sulfuric acid at sufficiently high temperature (300 °C) leads to a reduction of uranium to the tetravalent form under separation of green plates of U(SO 4 ) 2 [orthorhombic, Pbca , Z = 8, a = 940.11(2) pm, b = 898.13(2) pm, c = 1349.09(3) pm, V = 1.13909(4) nm 3 ]. The U 4+ ions in U(SO 4 ) 2 are in a square antiprismatic coordination of eight monodentate sulfate tetrahedra. By treatment of ThO 2 with sulfuric acid, the thorium (hydrogen)sulfates Th(SO 4 ) 2 [orthorhombic, Pbca , Z = 8, a = 953.74(3) pm, b = 911.49(3) pm, c = 1365.02(4) pm, V = 1.18665(6) nm 3 ], Th 4 (HSO 4 ) 2 (SO 4 ) 7 [tetragonal, I $\bar {4}$ 2 d , Z = 4, a = 1327.7(2) pm, c = 1362.8(2) pm, V = 2.402.3(6) nm 3 ] and Th(HSO 4 ) 2 (SO 4 ) [triclinic, P $\bar {1}$ , Z = 2, a = 576.18(2) pm, b = 896.11(3) pm, c = 948.58(3) pm, α = 65.387(2)°, β = 87.838(2)°, γ = 88.917(2)°, V = 0.44495(3) nm 3 ] could be obtained. Whereas Th(SO 4 ) 2 is isotypic with the respective uranium compound, both hydrogensulfates contain ninefold‐coordinated thorium to form a triple‐capped trigonal prism. The structure of Th(HSO 4 ) 2 (SO 4 ) can be described as a distorted variant of the UCl 3 structure type.
A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing strategies for managing positive human-animal relationships and disease prevention. Here, we describe the SARS-CoV-2 infection in a household of two human adults and sibling cats (one male and two females) using real-time RT-PCR, an ELISA test, viral sequencing, and virus isolation. On May 5th, 2020, the cat-owners tested positive for SARS-CoV-2. Two days later, the male cat showed mild respiratory symptoms and tested positive. Four days after the male cat, the two female cats became positive, asymptomatically. Also, one human and one cat showed antibodies against SARS-CoV-2. All cats excreted detectable SARS-CoV-2 RNA for a shorter duration than humans and viral sequences analysis confirmed human-to-cat transmission. We could not determine if cat-to-cat transmission also occurred.
Community-onset Clostridium difficile-associated diarrhoea not associated with antibiotic usage--two case reports with review of the changing epidemiology of Clostridium difficile-associated diarrhoea. (2008)

The emergence of hypervirulent strains of Clostridium difficile causing outbreaks in hospitals and nursing homes may result in a greater than before spread of the bacterium in the community. By consequence, the incidence of community-onset cases of Clostridium difficile-associated diarrhoea (CDAD) may increase outside known risk groups that are currently characterised by prior hospitalisation, prior antibiotic usage, older age and significant comorbidity. Here, we describe two case histories of community-onset CDAD. The first concerns a previously healthy young female with community-acquired CDAD without recent hospitalisation or antibiotic usage. The second patient developed diarrhoea in the community after discharge from a hospital where--in retrospect--an outbreak of CDAD occurred. The cases illustrate that CDAD should be included in the differential diagnosis of patients seeking care for community-onset diarrhoea, even in those without characteristic risk factors for CDAD.
Capacitive substrate coupling of row-column-addressed 2-D CMUT arrays (2016)

Row-column-addressed CMUT arrays suffer from low receive sensitivity of the bottom elements due to a capacitive coupling to the substrate. The capacitive coupling increases the parasitic capacitance. A simple approach to reduce the parasitic capacitance is presented, which is based on depleting the semiconductor substrate. To reduce the parasitic capacitance by 80% the bulk doping concentration should be at most 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . Experimental results show that the parasitic capacitance can be reduced by 87% by applying a substrate potential of 6V relative to the bottom electrodes. The depletion of the semiconductor substrate can be sustained for at least 10 minutes making it applicable for row-column-addressed CMUT arrays for ultrasonic imaging. Theoretically the reduced parasitic capacitance indicates that the receive sensitivity of the bottom elements can be increased by a factor of 2.1.