gebhart/patrepeval huggingface dataset:
Multistimuli-Responsive Amphiphilic Poly(ester-urethane) Nanoassemblies Based on l-Tyrosine for Intracellular Drug Delivery to Cancer Cells (2018)

Multistimuli-responsive l-tyrosine-based amphiphilic poly(ester-urethane) nanocarriers were designed and developed for the first time to administer anticancer drugs in cancer tissue environments via thermoresponsiveness and lysosomal enzymatic biodegradation from a single polymer platform. For this purpose, multifunctional l-tyrosine monomer was tailor-made with a PEGylated side chain at the phenolic position along with urethane and carboxylic ester functionalities. Under melt dual ester-urethane polycondensation, the tyrosine monomer reacted with diols to produce high molecular weight amphiphilic poly(ester-urethane)s. The polymers produced 100 ± 10 nm spherical nanoparticles in aqueous medium, and they exhibited thermoresponsiveness followed by phase transition from clear solution into a turbid solution in heating/cooling cycles. Variable temperature transmittance, dynamic light scattering, and <sup>1</sup>H NMR studies revealed that the polymer chains underwent reversible phase transition from coil-to-expanded chain conformation for exhibiting the thermoresponsive behavior. The lower critical solution temperature of the nanocarriers was found to correspond to cancer tissue temperature (at 42-44 °C), which was explored as an extracellular trigger (stimuli-1) for drug delivery through the disassembly process. The ester bond in the poly(ester-urethane) backbones readily underwent enzymatic biodegradation in the lysosomal compartments that served as intracellular stimuli (stimuli-2) to deliver drugs. Doxorubicin (DOX) and camptothecin (CPT) drug-loaded polymer nanocarriers were tested for cellular uptake and cytotoxicity studies in the normal WT-MEF cell line and cervical (HeLa) and breast (MCF7) cancer cell lines. In vitro drug release studies revealed that the polymer nanoparticles were stable under physiological conditions (37 °C, pH 7.4) and they exclusively underwent disassembly at cancer tissue temperature (at 42 °C) and biodegradation by lysosomal-esterase enzyme to deliver 90% of DOX and CPT. Drug-loaded polymer nanoparticles exhibited better cytotoxic effects than their corresponding free drugs. Live cell confocal microscopy imaging experiments with lysosomal tracker confirmed the endocytosis of the polymer nanoparticles and their biodegradation in the lysosomal compartments in cancer cells. The increment in the drug content in the cells incubated at 42 °C compared to 37 °C supported the enhanced drug uptake by the cancer cells under thermoresponsive stimuli. The present work creates a new platform for the l-amino acid multiple-responsive polymer nanocarrier platform for drug delivery, and the proof-of-concept was successfully demonstrated for l-tyrosine polymers in cervical and breast cancer cells.
Differential Cardiorespiratory Effects of Endomorphin 1, Endomorphin 2, DAMGO, and Morphine (2000)

The novel endogenous mu-opioid receptor (MOR) agonists endomorphin 1 (EM1) and 2 (EM2) were tested for their cardiorespiratory effects in conscious, freely behaving rats. After systemic (intravenous) administration of EM1, EM2, or the selective MOR agonist DAMGO, analgesia, minute ventilation (V E), heart rate (HR) and mean arterial blood pressure (BP) were measured. The threshold dose for analgesia was similar for all 3 peptides ( approximately 900 nmol/kg). All 3 compounds elicited biphasic V E responses, with marked, short-lived V E depressions (4-6 s) followed by more sustained V E increases (10-12 min). However, compared with responses elicited by EM2 or DAMGO, EM1 decreased V E only at higher doses, and produced greater V E stimulation. Morphine produced a V E decrease, but no subsequent V E increase. EM2 and DAMGO decreased HR and BP, while EM1 decreased HR, but did not decrease BP in conscious rats at doses up to 9,600 nmol/kg. In anesthetized rats, all 3 peptides decreased HR and BP. The decreases in V E, HR, and BP were blocked by the MOR antagonist, naloxone HCI (NIx). Only the HR and BP responses, however, were blocked by naloxone-methiodide (MeNIx), indicating central mediation of V E responses and peripheral mediation of cardiovascular responses. We conclude that MOR-selective compounds vary in their cardiorespiratory response characteristics which could be linked to differential cellular actions. The results support the concept that the analgesic, respiratory, and cardiovascular effects of MOR agonists can be dissociated and that EM1-like compounds could provide the basis for novel, safer analgesics.
Flexible constraint hierarchy during the visual encoding of tool‐object interactions (2021)

Tools and objects are associated with numerous action possibilities that are reduced depending on the task-related internal and external constraints presented to the observer. Action hierarchies propose that goals represent higher levels of the hierarchy while kinematic patterns represent lower levels of the hierarchy. Prior work suggests that tool-object perception is heavily influenced by grasp and action context. The current study sought to evaluate whether the presence of action hierarchy can be perceptually identified using eye tracking during tool-object observation. We hypothesize that gaze patterns will reveal a perceptual hierarchy based on the observed task context and grasp constraints. Participants viewed tool-objects scenes with two types of constraints: task-context and grasp constraints. Task-context constraints consisted of correct (e.g., frying pan-spatula) and incorrect tool-object pairings (e.g., stapler-spatula). Grasp constraints involved modified tool orientations, which requires participants to understand how initially awkward grasp postures can help achieve the task. The visual scene contained three areas of interests (AOIs): the object, the functional tool-end (e.g., spoon handle) and the manipulative tool-end (e.g., spoon bowl). Results revealed two distinct processes based on stimuli constraints. Goal-oriented encoding, the attentional bias towards the object and manipulative tool-end, was demonstrated when grasp did not lead to meaningful tool-use. In images where grasp postures were critical to action performance, attentional bias was primarily between the object and functional tool-end, which suggests means-related encoding of the graspable properties of the object. This study expands from previous work and demonstrates a flexible constraint hierarchy depending on the observed task constraints.
Intertrochanteric fractures: ten tips to improve results. (2009)

Intertrochanteric hip fractures are among the most common types of fractures, and the numbers are increasing as the population ages. Most intertrochanteric fractures are treated surgically. It is therefore important that the treatment methods are effective and have a minimal risk of complications. The goals of treatment include a predictable union, unrestricted early weight bearing, and avoidance of fixation failure or excessive deformity of the proximal femur. Careful attention to the fracture pattern (obliquity or other hallmarks implying instability) can guide fixation device selection. Regardless of the device, accurate reduction and implant placement are important to a good outcome.
Additions and Corrections - Degradation of Thiostrepton. Thiostreptoic Acid. (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Degradation of Thiostrepton. Thiostreptoic Acid.Miklos Bodanszky, John Sheehan, Josef Fried, Nina Williams, and Carolyn BirkhimerCite this: J. Am. Chem. Soc. 1960, 82, 24, 6431Publication Date (Print):December 1, 1960Publication History Published online17 May 2004Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/ja01509a641https://doi.org/10.1021/ja01509a641research-articleACS PublicationsRequest reuse permissionsArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell–Dependent Mechanisms (2019)

Our data reveal a promising, clinically relevant approach for immune modulation in transplantation by selectively targeting Notch-1.
Effects of secondary bonding interactions on the iron-sulfur cubane-type [Fe4S4]2+ core of ferredoxin site analogs: [Fe4S4(SC6H4-o-OH)4]2-, a distorted cubane-type cluster with one five-coordinate iron atom (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of secondary bonding interactions on the iron-sulfur cubane-type [Fe4S4]2+ core of ferredoxin site analogs: [Fe4S4(SC6H4-o-OH)4]2-, a distorted cubane-type cluster with one five-coordinate iron atomR. E. Johnson, G. C. Papaefthymiou, R. B. Frankel, and R. H. HolmCite this: J. Am. Chem. Soc. 1983, 105, 25, 7280–7287Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00363a013https://doi.org/10.1021/ja00363a013research-articleACS PublicationsRequest reuse permissionsArticle Views267Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Importance of stored triacylglycerols in Streptomyces: possible carbon source for antibiotics (1994)

Submerged cultures of four Streptomyces species accumulated triacylglycerol (TAG), ranging from 50 to 150 mg (l medium)-1, during the post-exponential phase of growth. S. lividans also produced glycogen (80 mg l-1). Identity of TAG species was confirmed after TLC, by mass spectroscopy and by quantitative IR spectroscopy and reaction of the hydroxamate derivatives with ferric chloride. This is the first substantive report showing the storage of TAG in bacteria. Distribution of diacylglycerol acyltransferase (TAG synthase) activity from S. coelicolor and S. lividans during incubation on different media paralleled the formation of TAG. Accumulation of TAG may be necessary to maintain cell integrity after glucose becomes exhausted from the medium, and also to provide the C2 units needed for subsequent biosynthesis of acetate-derived antibiotics in appropriate species. Actinorhodin was formed by S. coelicolor when grown on YEME medium only after exhaustion of glucose; the carbon source may therefore originate from TAG. All the organisms examined in this study formed isoprenoid-derived hydrocarbons (up to 3 mg l-1) which were identified as squalene plus hydrogenated derivatives.
Wireless Fingerprint Attendance System using ZigBee Technology (2012)

In this paper provides the design method of wireless fingerprint attendance system based on ZigBee technology. The system includes terminal fingerprint acquisition module and attendance management module through computer. It can realize automatically such functions as information acquisition of fingerprint, processing, wireless transmission, fingerprint matching, and attendance management. Considering the fact and topology of ZigBee network, a fingerprint acquisition module and a wireless alarm module were designed by using the fingerprint sensor and module respectively. The whole system was implemented wireless alarm through messages and internet in the GSM web. In order to achieve the simple and high real-time system, it realized low-cost and high-performance wireless fingerprint attendance function, which provided a new wireless fingerprint attendance system for enterprises and institutions.
Characterizing the function of the CD300e immunoregulatory molecule. (2018)

Abstract The CD300 molecules are a family of immunoglobulin-like molecules that have immune regulatory functions. It includes both inhibitory and triggering members, which are highly conserved within the family as well as across species. CD300e, the most restricted member of the family, is expressed in low amounts in most of tissue, whereas its expression is upregulated in different cancers, such as, colorectal, stomach, liver, ovarian and pancreatic cancer. CD300e is highly expressed on CD14+ monocytes. Differentiation of monocytes into dendritic cells (DCs) and macrophages down regulated their CD300e expression. As no monoclonal antibodies are available yet to mouse CD300e, we generated a CD300e knock-out (KO) mouse as an alternative approach to study its biology. We have characterized the changes in immune cells populations resulting from CD300e deletion. The CD300eKO mice are in general fit and reproductively healthy. Mice with CD300e deficiency has a significantly reduction in their circulating leukocytes compared to wild type mice. Hematopoietic stem cells from CD300eKO mice were capable of differentiating in vitro into DC or macrophages with normal antigen uptake and T cell stimulatory capacity. We are using CD300eKO mice to elucidate CD300e function by further testing a variety of functions in monocytic cells.
Vestibular Symptoms, Panic, and Phobia (1992)

AbstractThe interface between anxiety disorders and vestibular disorders is characterized by two areas of overlap. First, some vestibular symptoms are elicited in situations involving long visual distances or misleading visual or proprioceptive cues for motion or balance. This situational specificity can lead to the development of avoidance behavior similar to that in agoraphobia and height phobia. Second, vestibular symptoms are associated with changes in autonomic activity. These reactions may be indistinguishable from those experienced in anxiety.Given these two areas of overlap, it is not surprising that anxiety, panic, and phobic avoidance are frequent complaints in patients with balance disorders. Conversely, vestibular dysfunction is observed in some patients with panic disorder. A model for the interaction between anxiety and vestibular abnormalities is discussed.
Detection of the Spermicide Nonoxynol-9 Via GC-MS (2012)

The spermicide nonoxynol-9 is actually a complex mixture of dozens of closely related amphiphilic compounds, and the chemical properties of this assortment significantly hamper its characterization by GC-MS. The inability to perform routine GC-MS testing on nonoxynol-9 has limited its evidentiary value in forensic casework, which relies heavily on this technique for analysis. A disturbing trend in sexual assault is the use of condoms by assailants, to avoid leaving behind DNA evidence that can connect a perpetrator to a victim. This observation necessitates the development of alternative methods for the analysis of trace evidence that can show causal links between a victim and a suspect. Detection of lubricants associated with sexual assault is one such way to establish this connection. The development of GC-MS methods that permit facile detection of both nonoxynol-9 alone and nonoxynol-9 extracted from other complex matrices that have potential as trace evidence in sexual assault is reported. A detection limit of 2.14 μg of nonoxynol-9 is demonstrated, and a detailed mass spectral profile that elaborates on what is known of its structure is provided.
Doping Effect on Conducting Polymer‐Metal Schottky DC Generators (2018)

Abstract Conducting polymer‐metal Schottky diodes show an interesting mechanical energy‐to‐electricity conversion ability to generate direct current (DC) power without rectification. However, little is reported about how dopants in conducting polymer affect the energy conversion behavior of Schottky diodes. In this study, a novel effect of dopants on mechanical energy‐to‐DC electricity conversion of conducting polymer‐metal Schottky devices is demonstrated. Using polyaniline (PANI) as a model, conducting polymers doped with a series of protonic acids is prepared. Without dopant, the device exhibits low mechanical‐to‐electrical outputs. Protonic acid doping enhances device energy conversion ability, and the dopant molecular dimension plays a significant part in deciding device performance. When HCl is used as dopant, the PANI device could produce peak outputs of 0.9 V and 33.9 µA cm −2 under compressive impact. These novel understandings foster the design of DC generators for various applications.
Genome Report: De novo genome assembly and annotation for the Taita white-eye ( Zosterops silvanus ) (2020)

Abstract The Taita White-eye ( Zosterops silvanus ) is an endangered songbird endemic to the Taita Hills of Southern Kenya, where it is confined to small areas of fragmented forest. With diversification rates exceeding those reported in most other vertebrates, White-eyes are a prime example of a ‘great speciator’. Nevertheless, we still know surprisingly little about the genomic underpinnings leading to this extraordinary fast radiation. Here, we present a draft genome assembly (ZSil_MB_1.0) for the Taita White-eye generated from a blood sample of a wild, female bird captured in the Taita Hills, Kenya. By performing a de novo assembly with linked-reads and annotation of the assembly with the MAKER pipeline, we generated a 1.069 Gb assembly with a scaffold N50 of 1.105 Mb and an L50 of 244. After quality evaluation of the assembly, we identified 92.1% of BUSCOs complete or fragmented, indicating that our de novo assembly is of high quality. This new assembly provides a genomic resource for future studies into the evolutionary and comparative genomics of this rapidly diversifying group of birds.
Events with an isolated lepton and missing transverse momentum and measurement of W production at HERA (2010)

A search for events containing an isolated electron or muon and missing transverse momentum produced in e p collisions is performed with the H1 and ZEUS detectors at HERA. The data were taken in the period 1994-2007 and correspond to an integrated luminosity of 0.98 fb -1 . The observed event yields are in good overall agreement with the Standard Model prediction, which is dominated by single W production. In the e + p data, at large hadronic transverse momentum P X T > 25 GeV, a total of 23 events are observed compared to a prediction of 14.0 1.9. The total single W boson production cross section is measured as 1.06 0.16 (stat.) 0.07 (sys.) pb, in agreement with an Standard Model (SM) expectation of 1.26 0.19 pb.
Spacecraft solar array technology trends (2002)

Photovoltaic solar array systems are the most common method for providing spacecraft power generation. The flexibility and variability of the many array types and configurations combine to accommodate a multitude of mission applications and space environments. Solar array technologies and their system configurations changed dramatically over the years as more aggressive and demanding requirements were imposed. This paper addresses the historical solar array technology trends. The evolution of solar array technologies and the key requirements responsible for driving this evolution are presented. Industry growth trends towards future systems are identified. Evolutionary technological improvements in photovoltaics, structural platforms and deployment systems are shown. Array selection criteria for a variety of requirements, applications, and environments are presented. Solar array technologies required to meet future mission trends are shown.
Degrees of freedom of MIMO two-way X relay channel (2012)

In this paper, we study the degrees of freedom of a multiple-input multiple-output (MIMO) two-way X relay channel, i.e., a system with two groups of source nodes and one relay node, where each of the two source nodes in one group wants to exchange independent messages with both the two source nodes in the other group via the relay node. We only consider the symmetric case where each source node is equipped with M antennas while the relay is equipped with N antennas. We first show that the upper bound of the degrees of freedom is 2N when N ≤ 2M. Then by applying physical layer network coding and joint interference cancellation, we propose a novel transmission scheme for the considered network. We show that this scheme can always achieve this upper bound when N ≤ ⌊4M/3⌋.
Caractéristiques biologiques de la population de truites (Salmo trutta L.) de la rivière Oir (Manche, Basse-Normandie) en 1996-1997 (1997)

EDF;Electricité de France;Direction Etudes et Recherches. Département Environnement;Chatou (FRA)*INRA Rennes, Service documentation, BP 29, 35653 LE RHEU Cedex Diffusion du document : INRA Rennes, Service documentation, BP 29, 35653 LE RHEU Cedex
Integrated Computer Network for Acute Patient Care. (1984)

Care of the acutely ill hospitalized patient places unusual demands on the practicing physician. Large amounts of physiologic, laboratory and other patient related data must be quickly and efficiently obtained and acted upon. The therapy for these patients is complex and time dependent and must be accurately documented. To help meet these demands an integrated computer network has been established to speed data communications, provide integrated data reporting and assist in medical decision-making. Experience with this computer network and its impact on patient care are discussed.