gebhart/patrepeval huggingface dataset:
Protein Three-Dimensional Structural Databases: Domains, Structurally Aligned Homologues and Superfamilies (1998)

This paper reports the availability of a database of protein structural domains (DDBASE), an alignment database of homologous proteins (HOMSTRAD) and a database of structurally aligned superfamilies (CAMPASS) on the World Wide Web (WWW). DDBASE contains information on the organization of structural domains and their boundaries; it includes only one representative domain from each of the homologous families. This database has been derived by identifying the presence of structural domains in proteins on the basis of inter-secondary structural distances using the program DIAL [Sowdhamini & Blundell (1995), Protein Sci. 4, 506-520]. The alignment of proteins in superfamilies has been performed on the basis of the structural features and relationships of individual residues using the program COMPARER [Sali & Blundell (1990), J. Mol. Biol. 212, 403-428]. The alignment databases contain information on the conserved structural features in homologous proteins and those belonging to superfamilies. Available data include the sequence alignments in structure-annotated formats and the provision for viewing superposed structures of proteins using a graphical interface. Such information, which is freely accessible on the WWW, should be of value to crystallographers in the comparison of newly determined protein structures with previously identified protein domains or existing families.
Realization of Linear High-Frequency Transconductance in CMOS-Technology (1986)

It is shown that a CMOS class AB voltage-current converter circuit can be used as a wideband transconductor with variable highly linear transconductance. Linearity error less than 0.1% and THD of 0.16% for output signal current of 200% of the quiescent current value, and bandwidth of 5 MHz were measured on experimental chips. In addition, the circuit generates a useful square-law function.
Sildenafil administration to a patient with refractory persistent pulmonary hypertension of the newborn (2008)

Persistent pulmonary hypertension of the newborn (PPHN) is a multifactorial cardiopulmonary disorder with an incidence of 0.4–6.8 cases per 1000 term or near term births (>34 weeks). The disorder i...
Intravenous Formulations of the Enantiomers of Thalidomide: Pharmacokinetic and Initial Pharmacodynamic Characterization in Man (2000)

Thalidomide, a racemate, is coming into clinical use as an immunomodulating and antiinflammatory drug. These effects may chiefly be exerted by S-thalidomide, but the enantiomers are interconverted in-vivo. Thalidomide is given orally, although parenteral administration would be desirable in some clinical situations. The aim of this study was to prepare solutions of the enantiomers of thalidomide for intravenous administration and to investigate their pharmacokinetics and sedative effects following infusion in man. Solubility and stability of the enantiomers in 5% glucose solution was investigated. After a dose-determination experiment in one subject, six healthy male volunteers received R- and S-thalidomide separately by 1-h infusions in a randomized double-blind cross-over study. Blood was sampled over 22h and sedative effects were recorded. Blood concentrations of the enantiomers were determined by stereospecific HPLC. A four-compartment model consisting of a two-compartment model for each enantiomer, with elimination from both compartments, connected by rate constants for chiral inversion was fitted to the concentration data, while the sedative effects were correlated with the blood concentrations of R- and S-thalidomide by means of logistic regression. The enantiomers of thalidomide were chemically stable in solution for at least a week at room temperature. The infusions were well tolerated. Sedation, which was the only observed effect, was related to the blood concentration of R-thalidomide. Inter-individual variation in the disposition of the enantiomers was modest (e.g. terminal half-lives ranged between 3.9 and 5.3h). Pharmacokinetic modelling predicted that varying the infusion time of a fixed dose of S-thalidomide between 10 min and 6h would have little influence on the maximal blood concentration of formed R-thalidomide. To our knowledge this is the first time that thalidomide has been administered intravenously.
Craniofrontonasal dysostosis: variable expression in a three‐generation family (1990)

A family with craniofrontonasal dysostosis (craniofrontonasal dysplasia) is described. There were three severely affected females, two of them daughters of apparently healthy parents. Examination of the male relatives revealed orbital hypertelorism and other minor anomalies in two of them, including the father of the two affected daughters. This family emphasizes the wide variation in the phenotype of craniofrontonasal dysostosis and suggests that male relatives with minor manifestations of the syndrome may be at high risk of having severely affected daughters. The expression of the gene may be modified by the sex.
Diastereospecific Gold(I)‐Catalyzed Cyclization Cascade for the Controlled Preparation of N‐ and N,O‐Heterocycles (2018)

Abstract The reaction of oxime‐tethered 1,6‐enynes with a cationic gold(I) catalyst demonstrates a great potential for the synthesis of a range of heterocycles in a diastereospecific fashion. The control of the configuration of the oxime and the alkene of the enyne moiety is the key to selectively obtain dihydro‐1,2‐oxazines, isoxazolines or dihydropyrrole‐ N ‐oxides as single diastereoisomers. As supported by DFT calculations, these cascade reactions proceed stepwise, by the intramolecular addition of the O or N atom of the oxime onto cyclopropyl gold(I) carbene intermediates. In this study, a rare [3,3]‐sigmatropic rearrangement of nitrones is also observed.
Definition of global and transcript-specific mRNA export pathways in metazoans (2007)

Eukaryotic gene expression requires export of messenger RNAs (mRNAs) from their site of transcription in the nucleus to the cytoplasm where they are translated. While mRNA export has been studied in yeast, the complexity of gene structure and cellular function in metazoan cells has likely led to increased diversification of these organisms' export pathways. Here we report the results of a genome-wide RNAi screen in which we identify 72 factors required for polyadenylated [poly-(A(+))] mRNA export from the nucleus in Drosophila cells. Using structural and functional conservation analysis of yeast and Drosophila mRNA export factors, we expose the evolutionary divergence of eukaryotic mRNA export pathways. Additionally, we demonstrate the differential export requirements of two endogenous heat-inducible transcripts--intronless heat-shock protein 70 (HSP70) and intron-containing HSP83--and identify novel export factors that participate in HSP83 mRNA splicing. We characterize several novel factors and demonstrate their participation in interactions with known components of the Drosophila export machinery. One of these factors, Drosophila melanogaster PCI domain-containing protein 2 (dmPCID2), associates with polysomes and may bridge the transition between exported messenger ribonucleoprotein particles (mRNPs) and polysomes. Our results define the global network of factors involved in Drosophila mRNA export, reveal specificity in the export requirements of different transcripts, and expose new avenues for future work in mRNA export.
Can predation by invasive mice drive seabird extinctions? (2007)

The house mouse, Mus musculus, is one of the most widespread and well-studied invasive mammals on islands. It was thought to pose little risk to seabirds, but video evidence from Gough Island, South Atlantic Ocean shows house mice killing chicks of two IUCN-listed seabird species. Mouse-induced mortality in 2004 was a significant cause of extremely poor breeding success for Tristan albatrosses, Diomedea dabbenena (0.27 fledglings/pair), and Atlantic petrels, Pterodroma incerta (0.33). Population models show that these levels of predation are sufficient to cause population decreases. Unlike many other islands, mice are the only introduced mammals on Gough Island. However, restoration programmes to eradicate rats and other introduced mammals from islands are increasing the number of islands where mice are the sole alien mammals. If these mouse populations are released from the ecological effects of predators and competitors, they too may become predatory on seabird chicks.
Abundance of amino sugars and peptidoglycan in marine particulate and dissolved organic matter (2003)

Several recent studies indicated that amino sugars were likely to be major components of marine carbon and nitrogen cycles, but there has been insufficient data to investigate this hypothesis. In the present study, hydrolyzable amino sugars were measured in a variety of marine organisms and particulate organic matter (POM) and in ultrafiltered dissolved organic matter (UDOM) from various ocean basins and depths. Glucosamine (GlcN) and galactosamine (GalN) were abundant and common to all samples. Concentrations of these two amino sugars were similar to their neutral sugar counterparts, glucose and galactose, and in surface water they accounted for up to ~1.5% of C and N in POM and 2.5% of C and 7.1% of N in UDOM. Chitin, a polymer of glucosamine, is produced by many marine organisms, but based on the low GlcN : GalN ratios (1.0–2.5) in POM and UDOM, it does not appear to be a primary source of glucosamine in these samples. Muramic acid, an amino sugar found only in the bacterial cell wall polymer peptidoglycan, was relatively abundant in POM, indicating that bacterial detritus is a principal component of submicron particles in seawater. Muramic acid was measured in all UDOM samples, but its concentrations were low (&lt;1 nmol L −1 ), indicating that intact fragments of peptidoglycan were a relatively minor component of UDOM. The abundance of GlcN and GalN and their similar concentrations in POM and UDOM provide novel information suggesting a major prokaryotic source.
Immediate provisionalization of 3.0-mm-diameter implants replacing single missing maxillary and mandibular incisors: 1-year prospective study. (2012)

This 1-year prospective study showed a favorable implant success rate and peri-implant tissue response with immediately provisionalized 3.0-mm diameter implants replacing single missing maxillary and mandibular incisors. While prosthetic complications during the provisional phase were common, they were easily resolved without further consequences.
Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region (1998)

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.
Head acceleration and psychomotor performance. (1979)

Concussion resulting from head acceleration could explain the poor survival rates in some types of accidents. Experiments have been conducted on a decelerator using a tracking task to determine whether high head acceleration could affect psychomotor performance. Human subjects were exposed to impact acceleration of O (sham), 5, 10 and 12 -Gx facing forwards. Measurements were made of the linear and angular accelerations experienced at the head and a step tracking task was used to examine psychomotor performance. Electroencephalographs were also recorded. Both the linear and angular accelerations at the head were increased at the higher levels of impact acceleration. At -5Gx there were no significant differences in psychomotor performance when compared with controls, but at -10Gx, and especially -12Gx, significant differences were found. The EEG activity did not vary significantly and no concussive effects were observed in any subject. These results suggest that impairment of psychomotor performance severe enough to jeopardise survival could be produced by high accelerations of the head, though neither linear nor angular acceleration appear to have special significance.
Analysis of Secure Key Storage Solutions on Android (2014)

Mobile phones are increasingly used for security sensitive activities such as online banking or mobile payments. This usually involves some cryptographic operations, and therefore introduces the problem of securely storing the corresponding keys on the phone. In this paper we evaluate the security provided by various options for secure storage of key material on Android, using either Android's service for key storage or the key storage solution in the Bouncy Castle library. The security provided by the key storage service of the Android OS depends on the actual phone, as it may or may not make use of ARM TrustZone features. Therefore we investigate this for different models of phones.
Figure S4 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer (2023)

&lt;p&gt;miR-148b expression modulations in melanoma cells&lt;/p&gt;
Fumigant toxicity of Pistacia lentiscus essential oil against Tribolium castaneum and Lasioderma serricorne (2010)

International audience
Unexpected Potential of Iso-oligosaccharides in the Generation of Important Food Odorants (2019)

The generation of selected Maillard-derived odorants from iso-oligosaccharides (IOSs), namely, from isomaltose, isomaltotriose, isomaltulose, and melibiose, was studied and compared with that from other oligosaccharides (maltose, lactose, and panose) and monosaccharides (glucose, galactose, and fructose). The study was carried out in binary mixtures of sugar and amino acids (glycine, proline, and cysteine) and upon wafer baking. The results indicate that IOSs induce browning and generation of the majority of the monitored odorants, in particular 4-hydroxy-2,5-dimethyl-3(2 H)-furanone, 2,3-butanedione, 2-acetyl-1-pyrroline, 2-propionyl-1-pyrroline, 2-acetylthiazole, and 2-acetyl-2-thiazoline, far more than the other oligosaccharides and to a higher or similar degree to that of the monosaccharides. Plausible mechanisms, consistent with the yields obtained from individual sugars, were proposed for the formation of the studied compounds. This newly obtained data brought for the first time evidence about the extraordinary potential of IOSs in the formation of several potent food odorants.
Clinical relevance of serum natalizumab concentration and anti-natalizumab antibodies in multiple sclerosis (2012)

Our data show that both low natalizumab serum concentration and high antibody titers are associated with a lack of efficacy of natalizumab. Measuring serum natalizumab, using a highly specific assay, might lead to more enhanced precision using natalizumab in individual patients.
Analysis of strain and dislocation evolution during MOCVD growth of an AlGaN/GaN power high-electron-mobility transistor structure (2019)

Abstract We present the results of a comprehensive analysis of GaN-on-Si based HEMT epi-wafers grown by metal-organic chemical vapor deposition (MOCVD) in a production-scale reactor. An AlGaN/AlN superlattice was used as the buffer layer. Detailed characterization was combined with process modeling by STREEM-AlGaN software. Comparative analysis of modeling results, characterization data, and in situ curvature measurements allows the study of the evolution of structural properties of the epi-wafer during growth. The initial compressive mean stress in the superlattice gradually decreases during starting period of the growth and then becomes almost constant. The filtering of the dislocations is more effective in the bottom part of the SL, as both experiment and modeling demonstrate large inclination of dislocations in AlGaN layers of the superlattice, while the predicted dislocation density decreases due to annihilation. Proposed buffer layer and growth recipe resulted in final reduction of the dislocation density to ∼2 · 10 8 cm −2 with good structural uniformity over 6″ wafers and a residual bow below 50 μ m.
Automated phase assignment for the synthesis of low power domino circuits (1999)

High performance circuit techniques such as domino logic have migrated from the microprocessor world into more mainstream ASIC designs. The problem is that domino logic comes at a heavy cost in terms of total power dissipation. For mobile and portable devices such as laptops and cellular phones, a high power dissipation is an unacceptable price to pay for high performance. Hence, we study synthesis techniques that allow designers to take advantage of the speed of domino circuits while at the same time to minimize total power consumption. Specifically, in this paper we present three results related to automated phase assignment for the synthesis of low power domino circuits: (1) We demonstrate that the choice of phase assignment at the primary outputs of a circuit can significantly impact power dissipation in the domino block (2) We propose a method for efficiently estimating power dissipation in a domino circuit and (3) We apply the method to determine a phase assignment that minimizes power consumption in the final circuit implementation. Preliminary experimental results on a mixture of public domain benchmarks and real industry circuits show potential power savings as high as 34% over the minimum area realization of the logic. Furthermore, the low power synthesized circuits still meet timing constraints.
Modeling Network Medium Access Protocols for Network Quality of Service Analysis (2015)

Design-time analysis and verification of distributed real-time embedded systems necessitates the modeling of the time-varying performance of the network and comparing that to application requirements. Earlier work has shown how to build a system network model that abstracted away the network's physical medium and protocols which govern its access and multiplexing. In this work we show how to apply a network medium channel access protocol, such as Time-Division Multiple Access (TDMA), to our network analysis methods and use the results to show that the abstracted model without the explicit model of the protocol is valid.
The Relationship Between Spectral Changes in Heart Rate Variability and Fatigue (2009)

Fatigue is a prevalent problem in the workplace and a common symptom of many diseases. However, its relationship with the autonomic nervous system, specifically with sympathetic arousal, needs clarification. The objective of this study was to determine the association between fatigue and heart rate variability (HRV). HRV is regarded as an indicator of the autonomic regulation activity of heart rate, specifically sympathetic and parasympathetic activity. Spectral changes in low-frequency (LF; 0.04–0.15 Hz) and high-frequency (HF; 0.15–0.4 Hz) components of HRV have been reported to be associated with distressing conditions such as hemorrhagic shock, acute myocardial infarction, elevated anxiety, and depressed mood. While HRV changes have been found in persons with chronic fatigue syndrome, its association with fatigue in healthy individuals still needs clarification. HRV was assessed in a total of 50 participants who were asked to perform a task until becoming fatigued. Low-frequency HRV activity increased, while indices of parasympathetic modulation such as RMSSD and pNN50 remained stable as participants experienced fatigue, suggesting that fatigue in healthy individuals may be associated with increased sympathetic arousal. In addition, employing multiple regression analyses, we could positively associate the change in LF/HF HRV ratio from baseline to fatigue with factors such as emotional stability, warmth and tension and negatively associate it with social boldness and self-reported levels of vigor.
Metamaterials in microwave sensing applications (2010)

Metamaterials are artificial structures that have some unique properties suitable for a wide range of sensing applications. Based on these structures we have developed different types of sensors, using combined right/left-handed (CRLH) metamaterial transmission lines (TL). A cylindrical mass flow sensor and two types of planar sensors for position detection are presented. The area of application of these prototypes is industrial processes, where the sensing and control of all tasks involved in a system is crucial for a successful performance. All the sensor prototypes are analyzed and tested in dedicated measurement setups to proof the concepts.
As-deposited Sb-doped Bi-Pb-Sr-Ca-Cu-O thin films prepared by pulsed laser deposition (1990)

Superconducting Bi-Pb-Sr-Ca-Cu-O films doped with Sb have been fabricated on MgO single-crystal substrates without post-annealing, using pulsed excimer laser deposition. Deposition at 800 °C in 0.2 Torr oxygen environment from a target doped with Sb yielded as-deposited superconducting films with zero resistance at 70 K. X-ray diffraction data show the films are c-axis oriented 2212 phase material. Scanning electron micrographs indicate that doping with Sb enhances grain growth. These results demonstrate that Sb acts to stabilize the 2212 phase in the as-deposited films.
The effect of process conditions on pulp quality development at low consistency refining of mechanical pulp - TMP (2009)

Low consistency refining (LC) as a second refining stage, after a HC-defibration is an energy-efficient process solution. This HC-LC concept has for some time been explored in pilot scale and shown ...
Lyapunov Optimization-based User Scheduling and Beamforming Design for uRLLC Systems (2023)

Finite blocklength (FBL) transmission is a promising technique to meet the stringent delay and reliability requirements. In this paper, based on the FBL transmission mode, we formulate a joint user scheduling and beamforming (USBF) optimization problem with maximizing the system utility related to the long-term average rate, which considers variable user numbers and statistical wireless channels. To address the long-term optimization problem, by utilizing the Lyapunov optimization method, it can be transformed into the admission control subproblem and the joint USBF subproblem with the instantaneous channel state information (CSI) of each user. Then, an iteration method with successive convex approximation (SCA) is presented to solve the transformed instantaneous optimization problem. The simulation results confirm that the proposed scheme can achieve a significant performance gain on the premise of meeting the requirements of uRLLC.
ChemInform Abstract: Resorcinolic Lipids, the Natural Non‐Isoprenoid Phenolic Amphiphiles and Their Biological Activity (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.