gebhart/patrepeval huggingface dataset:
A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine device (1997)

The intrauterine device (IUD) is an effective method of birth control. However, IUD-induced uterine bleeding is a major side-effect and always causes inconvenience, sometimes even anaemia. It has been reported that oral administration of indomethacin could can reduce IUD-induced uterine bleeding. In the present study, we investigated whether indomethacin-releasing copper IUD (IR-Cu-IUD) can prevent insertion-induced uterine bleeding and its mechanism. Nine healthy volunteers of reproductive age were selected for the study. Endometrial tissues were collected at same menstrual stage prior to and 3-6 months after IR-Cu-IUD insertion. Endometrial morphology, cell proliferation/differentiation, morphometry and activity of complement Factor VIII were examined. No significant difference was found in any of the parameters examined in the same patients, both prior to and after IR-Cu-IUD insertion. By comparison with data previously obtained from the patients who had Cu-IUD insertions, it is clear that IR-Cu-IUD markedly reduced IUD-induced uterine bleeding and this reduction is primarily contributed by the anti-inflammatory action of indomethacin.
Evaluation of Global Satellite Rainfall Products over Continental Europe (2012)

Abstract An extensive evaluation of two global-scale high-resolution satellite rainfall products is performed using 8 yr (2003–10) of reference rainfall data derived from a network of rain gauges over Europe. The comparisons are performed at a daily temporal scale and 0.25° spatial grid resolution. The satellite rainfall techniques investigated in this study are the Tropical Rainfall Measuring Mission (TRMM) 3B42 V6 (gauge-calibrated version) and the Climate Prediction Center morphing technique (CMORPH). The intercomparison and validation of these satellite products is performed both qualitatively and quantitatively. In the qualitative part of the analysis, error maps of various validation statistics are shown, whereas the quantitative analysis provides information about the performance of the satellite products relative to the rainfall magnitude or ground elevation. Moreover, a time series analysis of certain error statistics is used to depict the temporal variations of the accuracy of the two satellite techniques. The topographical and seasonal influences on the performance of the two satellite products over the European domain are also investigated. The error statistics presented herein indicate that both orography and seasonal variability affect the efficiency of the satellite rainfall retrieval techniques. Specifically, both satellite techniques underestimate rainfall over higher elevations, especially during the cold season, and their performance is subject to seasonal changes. A significant difference between the two satellite products is that TRMM 3B42 V6 generally overestimates rainfall, while CMORPH underestimates it. CMORPH’s mean error is shown to be of higher magnitude than that of 3B42 V6, while in terms of random error variance, CMORPH exhibits lower (higher) values than those of 3B42 V6 in the winter (summer) months.
Mode dispersion and photonic storage in planar defects within Bragg stacks of photonic crystal slabs (2004)

It is shown that electromagnetic energy can be localized to defect regions bounded by parallel planar walls perpendicular to the stack surface in Bragg stacks of two-dimensional photonic crystals. These regions produce larger bandgaps than single-photonic-crystal slabs. Group velocity and dispersion relations can easily be tailored by choice of the proper geometry and materials. Results indicate that such photonic crystals might facilitate photonic trapping and storage together with advanced photonic manipulations.
Involvement of β-Adrenergic Receptor Kinase-1 in Homologous Desensitization of Histamine H<sub>2</sub> Receptors in Human Gastric Carcinoma Cell Line MKN-45 (1996)

The poorly differentiated human gastric carcinoma cell line MKN-45 possesses histamine H2 receptors which are homologously desensitized by histamine. In order to clone the cDNA of a receptor kinase specific for H2 receptors, we performed RT-PCR at a low annealing temperature using oligo-DNA primers bearing the conserved sequences of the kinase domain of the G protein-coupled receptor kinase (GRK) family. However, we were able to isolate only cDNAs for beta-adrenergic receptor kinase 1 (beta ARK1) and GRK6. Interestingly, treatment of MKN-45 cells with beta ARK1 antisense phosphorothioate oligo-DNA (PON) resulted in significant loss of desensitization of H2 receptors by histamine, whereas GRK6 antisense PON had no effect. Thus, beta ARK1 appears to be involved in the homologous desensitization of H2 receptors in MKN-45 cells.
Diet and Alzheimer’s disease risk factors or prevention: the current evidence (2011)

Preventing or postponing the onset of Alzheimer's disease (AD) and delaying or slowing its progression would lead to a consequent improvement of health status and quality of life in older age. Elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment (MCI). Furthermore, at present, epidemiological evidence suggests a possible association between fish consumption, monounsaturated fatty acids and polyunsaturated fatty acids (PUFA; in particular, n-3 PUFA) and a reduced risk of cognitive decline and dementia. Poorer cognitive function and an increased risk of vascular dementia (VaD) were found to be associated with a lower consumption of milk or dairy products. However, the consumption of whole-fat dairy products may be associated with cognitive decline in the elderly. Light-to-moderate alcohol use may be associated with a reduced risk of incident dementia and AD, while for VaD, cognitive decline and predementia syndromes, the current evidence is only suggestive of a protective effect. The limited epidemiological evidence available on fruit and vegetable consumption and cognition generally supports a protective role of these macronutrients against cognitive decline, dementia and AD. Only recently, higher adherence to a Mediterranean-type diet was associated with decreased cognitive decline, although the Mediterranean diet (MeDi) combines several foods, micro- and macro-nutrients already separately proposed as potential protective factors against dementia and predementia syndromes. In fact, recent prospective studies provided evidence that higher adherence to a Mediterranean-type diet could be associated with slower cognitive decline, reduced risk of progression from MCI to AD, reduced risk of AD and a decreased all-cause mortality in AD patients. These findings suggested that adherence to the MeDi may affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia. Based on the current evidence concerning these factors, no definitive dietary recommendations are possible. However, following dietary advice for lowering the risk of cardiovascular and metabolic disorders, high levels of consumption of fats from fish, vegetable oils, nonstarchy vegetables, low glycemic index fruits and a diet low in foods with added sugars and with moderate wine intake should be encouraged. Hopefully this will open new opportunities for the prevention and management of dementia and AD.
Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo (1988)

Abstract The vascular endothelium plays an important role in fibrinolysis by producing tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI). The monokine tumor necrosis factor (human recombinant TNF) increased the production of PAI by cultured human endothelial cells from umbilical vein (twofold) and from foreskin microvessles (four to eight fold). This was demonstrated by titration of endothelial cell-conditioned medium with t-PA, by reverse fibrin autography, and by immunoprecipitation of [35S]PAI-1 by anti-PAI-1 IgG. TNF also induced a marked increase of PAI-1 messenger RNA (mRNA) in the cells. The stimulation of PAI activity by TNF was seen at 4 U/mL and reached a maximum at 500 U/mL. Human recombinant lymphotoxin and interleukin-1 (alpha and beta) also stimulated the production of PAI activity, while interleukin-6 was ineffective. Separate additions of TNF or interleukin-1 (IL-1) at optimal concentrations (500 U/mL and 5 U/mL, respectively) resulted in a comparable stimulation of PAI production by endothelial cells. The simultaneous addition of both mediators resulted in an additive effect. The effect of TNF could not be prevented by the addition of polymyxin B or by anti-IL-1 antibodies. Therefore, it is unlikely that TNF acts through the induction of IL-1 secretion by endothelial cells. Two hours after a bolus injection of 250,000 U/kg TNF into rats, a fivefold increase in circulating PAI levels was found. In the next ten hours, the levels returned to normal. Blood platelets do not significantly contribute to the increase in circulating PAI, because the number of platelets did not change after TNF injection and the amount of PAI in blood platelets is not sufficient for several hours during an increase in PAI activity. The acute phase reactants, fibrinogen and alpha 2-antiplasmin in rat plasma, were altered little if any two to 24 hours after injection of 250,000 U/kg TNF. In vitro, TNF did not change PAI production by human and rat hepatocytes in primary monolayer culture. Therefore, it is most likely that vascular endothelial cells contribute to the increased amount of circulating PAI induced by TNF in vivo. This increase in PAI activity might decrease fibrinolysis.
Aberrant p53 Signaling Pathways in RPL11 Mutant Zebrafish (2008)

Abstract Diamond Blackfan Anemia (DBA) is a congenital syndrome characterized by decreased production of red blood cells and developmental abnormalities. This syndrome is caused by mutations in ribosomal genes (RPs), most frequently in RPS19, RPL11, and RPL5. Previously, we created RPS19 deficient zebrafish using morpholinos and demonstrated that p53 family members mediate the effects of RPS19 deficiency on development and hematopoiesis through upregulation of p53-related proteins. In this study, we found that RPL11 mutations, similar to RPS19 deficiency, leads to dysregulation of p53, its related family members, and downstream signaling pathways in zebrafish. Expression of both total p53 and Δ113Np53 is strongly upregulated in mutants with more modest upregulation of ΔNp63. The p53 protein also induced p21 and G1 cyclin expression, which resulted in cell cycle arrest. The pro-apoptotic genes, puma and bax, were also upregulated. We observed that the expression of several genes involved in hematopoiesis was altered, for example, globin gene expression was decreased. The ΔNp63 protein, which increases expression of adenosine deaminase (ADA) and is upregulated in &amp;gt;70% of DBA patients, was also upregulated in RPL11 zebrafish mutants. Interestingly, we also observed increased expression of the proto-oncogenes c-fos, c-jun, and c-myc in RPL11 mutants. Increased expression of proto-oncogenes may contribute to the mechanisms of transcriptional activation by p53 family members in response to ribosomal protein deficiency. Furthermore, aberrant expression of oncogenes could provide a possible mechanism for the increased risk of malignancies in DBA patients. We propose that the zebrafish is a model system to study developmental and hematologic defects in addition to signaling pathways in the pathogenesis of DBA.
Monoclonal Anti‐A from a Hybrid‐Myeloma: Evaluation as a Blood Grouping Reagent (1980)

A monoclonal anti-A antibody has been evaluated and found suitable for use as a potent routine ABO grouping reagent, without the use of additives. The IgM anti-A (MH2/6D4) is secreted into the tissue culture supernatant by a permanent line of cloned cells derived by fusion of anti-A producing spleen cells and a mouse myeloma cell line. This is a cost-effective reagent which should reduce production costs by over 50%. This reagent has the advantages inherent in monoclonal antibodies among them the availability of unlimited quantities of unvarying antibody of known properties.
Battery ripple current reduction in a three-phase interleaved dc-dc converter for 5kW battery charger (2011)

This paper proposes a battery ripple current reduction method and design of three-phase interleaved dc-dc converter for 5kW battery charger, which is applied for stabilizing a wind-power generating system. The charger consists of three-phase interleaved dc-dc converter, which is the interface of batteries and DC link, and a grid connected inverter. Lead-acid battery is modeled in the first order R-C model by MATLAB/Simulink and battery parameters are measured by the pulsed current and constant current discharge test. The battery is connected to the three-phase interleaved dc-dc converter in order for reduction of ripple current to 8% from 32.5%, increase of battery lifetime and reduction of total size of inductors. The ripple current is further reduced to 2% from 8% by connecting a filter capacitor and design rule of filter capacitor is analyzed. The controller for charging and discharging mode is designed and the proposed reduction methods of battery ripple currents are verified in a 5kW charger.
Numerical simulation of orthotropic steel deck bridges with two membrane layers systems (2013)

The finite element system CAPA-3D was utilized as the numerical simulation platform,two structural FE models of orthotropic steel bridge decks were set up,the static and dynamic FE simulations under different loading conditions were carried out,the special attention was given to identify the critical wheel load location,and the maximum tensile stress distribution and the variation of strain rate inside membrane layers.Simulation result shows that the FE models are capable of simulating the realistic behavior of orthotropic steel bridge.The distributions of strains and stresses inside the surfacing materials depend highly on wheel load level,wheel load frequency,wheel position,membrane bonding strength as well as the thicknesses and characteristics of surfacing layers.The maximum tensile stress of membrane layers is found around 0.4MPa,which coincides with the minimum requirement for the adhesive bonding strength of membrane material proposed by the standards NF P98-282and TP-BEL-B.The maximum membrane strain rate is found around 0.1,which is an important information that can be utilized for the characterization of membrane products.1tab,28figs,7refs.
Transgenic animal methodologies and their applications. (1993)

In the past 10 years the capacity has been acquired to genetically transform mammals via insertion of genes into developmentally totipotent embryonic cells. This profound advance has impacted significantly on our understanding of basic mechanisms of gene regulation, and has enabled practitioner's of this "transgenic technology" to establish important paradigms for the genetic engineering of experimental animals and livestock. The two most powerful forms of genetic engineering to emerge from this research include the targeted expression of foreign genes, or transgenes, and the ability to target specific endogenous mouse genes for mutagenesis. In this presentation I will outline the general principles underlying this technology, and provide examples of its use in research on cancer and aging that are ongoing in our laboratory.
Asymmetric Hydrogenation of Unprotected Indoles Catalyzed by η6-Arene/N-Me-sulfonyldiamine–Ru(II) Complexes (2016)

Protecting-group-free transformation is a challenging and important issue in atom-economical organic synthesis. The η(6)-arene/N-Me-sulfonyldiamine-Ru(II)-BF4 complex-catalyzed asymmetric hydrogenation of 2-substituted unprotected indoles in weakly acidic hexafluoroisopropanol gives optically active indoline compounds with up to >99% ee. Under mild reaction media, halogen atoms and synthetically important protecting groups (e.g., silyl ether, acetal, benzyl ether, and ester) on indoles are maintained, which is advantageous for the synthesis of further complex indoline molecules.
Brayton cycle heat recovery for container-glass melting furnace (1981)

A Brayton Cycle system of gas turbines to generate electrical power and of heat exchangers to provide secondary preheat to combustion air is shown to recover a significant amount of waste heat from the flue gas of a regenerative, container-glass melting furnace. Potential materials problems with the systems have been considered, and a program to evaluate these problems is in progress. 24 refs.
Infectious hepatitis A virus particles produced in cell culture consist of three distinct types with different buoyant densities in CsCl. (2020)

Although hepatitis A virus (HAV) released by infected BS-C-1 cells banded predominantly at 1.325 g/cm3 (major component) in CsCl, smaller proportions of infectious virions banded at 1.42 g/cm3 (dense HAV particles) and at 1.27 g/cm3 (previously unrecognized light HAV particles). cDNA-RNA hybridization confirmed the banding of viral RNA at each density, and immune electron microscopy demonstrated apparently complete viral particles in each peak fraction. The ratio of the infectivity (radioimmunofocus assay) titer to the antigen (radioimmunoassay) titer of the major component was approximately 15-fold greater than that of dense HAV particles and 4-fold that of light HAV particles. After extraction with chloroform, the buoyant density of light and major component HAV particles remained unchanged, indicating that the lower density of the light particles was not due to association with lipids. Light particles also banded at a lower density (1.21 g/cm3) in metrizamide than did the major component (1.31 g/cm3). Dense HAV particles, detected by subsequent centrifugation in CsCl, were indistinguishable from the major component when first banded in metrizamide (1.31 g/cm3). However, dense HAV particles recovered from CsCl subsequently banded at 1.37 g/cm3 in metrizamide. Electrophoresis of virion RNA under denaturing conditions demonstrated that dense, major-component, and light HAV particles all contained RNA of similar length. Thus, infectious HAV particles released by BS-C-1 cells in vitro consist of three distinct types which band at substantially different densities in CsC1, suggesting different capsid structures with varied permeability to cesium or different degrees of hydration.
A spatial-spectral classification approach of multispectral data for ground perspective materials (2011)

A spatial-spectral classification technique for classification of materials within Hyperspectral images is described in this paper. The method considers the influence of neighboring pixels to apply local spatial context features to correctly label an unknown pixel. The spatial and spectral features are jointly applied to a Maximum Likelihood classifier that uses material class models defined by a Mixture of Gaussians to adaptively account for spectral variability and noise. Experimental results compare the application of spatial and spectral features with only spectral features on the classification of materials common to scenes viewed from the ground perspective.
Phase I/II study of preoperative (pre-op) short course chemoradiation (CRT) with proton beam therapy (PBT) and capecitabine (cape) followed by early surgery for resectable pancreatic ductal adenocarcinoma (PDAC) of the head. (2012)

4021 Background: Standard adjuvant 6 week CRT may delay and reduce tolerability of adjuvant gemcitabine-based chemotherapy. We explore the safety and efficacy of a one-week course of pre-op CRT with PBT and cape followed by early pancreaticoduodenectomy (PD). Methods: Patients with radiographically resectable, biopsy-proven PDAC of the head were enrolled from May 2007-December 2010 on this prospective, NCI-sponsored clinical trial. Eligibility included no CT involvement of SMA or celiac artery; No metastatic disease. Dose level 1 consisted of PBT delivered 3 Gy x 10. Pts in subsequent dose levels received 5 Gy x 5 in progressively shortened schedules: level 2 (wk 1 M W F, wk 2 T Th), level 3 (wk 1 M T Th F, wk 2 M), level 4 (wk 1 M-F). PBT was targeted at pancreatic mass with elective nodal coverage. Pts received Cape 825 mg/m2 BID wk 1 and 2 M-F. Surgery was performed 1-6 wks after completion of cape. Patients were recommended to receive 6 mo of gemcitabine after surgery. Genotyping of 15 genes (including KRAS, PIK3CA, BRAF, NRAS, TP53, IDH1) was performed. Results: 50 pts were enrolled on study. 48 patients are eligible for this analysis. 3 pts were treated at each of dose levels 1-3. 6 pts were at dose level 4, which was selected as MTD. No DLTs were observed. 35 patients were treated in the phase II portion at the MTD. Gr 3 toxicity was noted in 2 pts (chest wall pain-1, colitis-1). 38 pts underwent PD. Reasons for no PD were: metastatic disease-9, unresectable tumor-1. Mean post-op length of stay was 7 days (range 5-47). 6/38 (16%) resected pts had positive margins. 28/38 (74%) had positive nodes. Median follow up is 21 months among the 19 patients still alive. 4/48 (8%) local failures in ALL patients. mOS and mPFS are 18 and 10 months respectively for ALL patients and 27 and 14 months for RESECTED patients. Of 28 patients with genotype data available, 22 (79%) had KRAS mutations. 10/22 KRAS mt and 4/6 KRAS wt pts are alive. Conclusions: Pre-op CRT with 1 wk of PBT and capecitabine followed by early surgery is well tolerated and associated with favorable local control. Complete genotype and DPC4 data will be presented at the meeting.
ChemInform Abstract: Bond Strengths of Ethylene and Acetylene. (1990)

Abstract Negative ion photoelectron spectroscopy and gas‐phase proton transfer kinetics are employed to determine the CH bond dissociation energies of HC≡CH, H2C=CH2, and vinyl radical.
Pantothenic Acid Uptake and Metabolism by Red Blood Cells of Rats (1995)

Red blood cells (RBC) of rats and humans contain pantothenic acid (PA) derivatives, generally referred to as bound PA, which were never characterized or quantitated. This study was undertaken to define those factors that determine the rates of uptake and efflux of PA, and possibly PA derivatives, in RBC. Uptake of PA by RBC was studied by incubating RBC with different concentrations of PA (0.34-34.0 mumol/L), each containing [14C]PA (0.34 mumol/L) at 37 degrees C for 3-360 min. The effects of Na+, energy and pH on the uptake of PA in RBC were determined in experiments varying media concentrations of Na+ (0-152 mmol/L), glucose (0 and 10 mmol/L) or pH (7.2-7.6). The release of PA from RBC was studied by incubating RBC containing [14C]PA (0.10-10.4 nmol/10(7) RBC, final concentration) in fresh media at 37 degrees C for 10-240 min. Uptake and efflux of PA were found to be nonsaturable; uptake was not affected by Na+, energy or pH. Quantitative and qualitative determination of PA derivatives was by enzymatic hydrolysis of lysed RBC, followed by analysis of PA by RIA and paper chromatography. The RBC were found to contain PA, 4'-phosphopantothenic acid and pantetheine. We conclude that PA diffuses passively into and out of RBC and that RBC contain only PA, 4'-phosphopantothenic acid, pantetheine and no CoA.
NOVA ESPÉCIE DE Mormodes LINDL. PARA A AMAZÔNIA BRASILEIRA (2019)

As orquideas constituem um dos grupos mais numerosos entre as Angiospermas. A Familia Orchidaceae Juss. esta dividida em cinco subfamilias, e Epidendroideae Kostel. abriga a tribo Cymbidieae Pfitzer com a subtribo Catasetinae Schltr., no qual esta inserido o genero Mormodes Lindl. O presente estudo descreve e ilustra uma nova especie deste genero para o Brasil, Amazonia, caracterizada por ter um labelo carnoso, severamente trilobado, encurvado (forma de sela) 23,4 × 21,7 mm, base unguiculada e ligada a coluna, lobos laterais romboides e com reentrância visivel, arcados para o centro, lobo central com margem trigono-denticulada de tamanho aproximado aos laterais. Palavras-chave: Biodiversidade, Brasil, Neotropicos, Novidade nomenclatural.