gebhart/patrepeval huggingface dataset:
Combination radiofrequency thermal ablation and adjuvant IV liposomal doxorubicin increases tissue coagulation and intratumoural drug accumulation (2004)

There has been marked interest in minimally-invasive, image-guided radiofrequency (RF) tumour ablation (i.e. coagulating tumour using short duration heating ( < 15 min) by directly applying temperatures > 50 degrees C via needle electrodes) to treat focal liver, renal, breast, bone and lung tumours. In spite of advances in RF technology and improved understanding of tumour biophysiology that now enable experimental treatment of tumours up to 5cm, investigators have been unable to achieve complete ablation in many cases, particularly at the tumour margins and adjacent to blood vessels. One strategy for overcoming these limitations has been to take advantage of complementary interactions between RF thermal ablation and chemotherapy, particularly liposomal doxorubicin preparations, to attempt more complete tumour destruction. This paper will review published laboratory investigations demonstrating that this combined treatment paradigm has the unique potential both to potentiate preferential delivery of cytotoxic agents in liposome vehicles and to maximize the completeness of ablation of a treated tumour. New confirmatory data describing increased tumour destruction with RF ablation combined with different liposome preparations, documenting increased lipid peroxidation and expanding on previously published tumour growth studies is presented. Additionally, early clinical data including a randomized, pilot clinical study on 10 patients with primary and metastatic liver tumours, in which a non-optimized combination of RF ablation and IV liposomal doxorubicin (Doxil) increased the volume of tumour destruction 25-30% compared to RF alone, will also be described in detail.
Effects of singlet and triplet energy transfer to molecular dopants in polymer light-emitting diodes and their usefulness in chromaticity tuning (2001)

Efficient, white emission with Commission Internationale de L’Eclairage coordinates of 0.33, 0.42 is demonstrated from polymer light-emitting diodes operating at high brightness. An amino endcapped polyfluorene derivative doped with rubrene was used as the active layer, in combination with a poly(3,4-ethylenedioxythiophene) hole transport layer. Luminescence reaches 14950 Cd/m2 at a current density of 150 mA/cm2, and the maximum external quantum efficiency measured 1.05% for a bias voltage of 9.0 V. We observe a fall in external quantum efficiency relative to the undoped device, which we ascribe to an increased singlet–triplet annihilation rate at the dopant sites.
Case of tardive dystonia improved by aripiprazole (2010)

ALTHOUGH THE EFFICACY of atypical antipsychotics, such as clozapine, quetiapine (QTP), and olanzapine (OLZ), for tardive dystonia (TD) has been reported,1 the prognosis is generally poor. Herein, we report a case of TD following the administration of antipsychotics, which was improved by aripiprazole (APZ). The case was a 24-year-old woman who developed delusions of persecution, in August in 2004. She was diagnosed with schizophrenia and the administration of risperidone (RIS) (2 mg/day) was initiated. The dose of RIS was increased to 4 mg/day, and delusions improved. Muscle contractions (involuntary movement) appeared in February in 2007, with the patient's head tilted rightward. Although biperiden (6 mg/ day) was added, the symptom remained. A neurological examination revealed no abnormalities other than this movement. The score of the drug-induced extra-pyramidal symptoms scale (DIEPSS)2was 6 points. There was no family history of dystonia. Electroencephalography, computed tomography, magnetic resonance imaging, and ceruloplasmin were normal. The patient was diagnosed with TD. Because of the persistence of her psychotic symptoms, her antipsychotic medications could not be reduced. A change in medication from RIS to APZ was started on 27 June in 2009, with the initial dose of APZ at 6 mg/day. The tilt of the head improved on 11 July. The administration of RIS was discontinued when the dose of APZ was increased to 24 mg/day on 22 August. On 5 September, the DIEPSS score was 2 points, showing improvement. APZ exhibits a pharmacological effect different from that of other atypical antipsychotics. APZ has a high affinity for receptors of dopamine (D2, D3) and serotonin (5-HT1A, 5-HT2A, and 5-HT2B), and acts as a partial agonist of D2 and 5-HT1A, and as an antagonist of 5-HT2A and 5-HT2B. It has been reported that the incidence of APZ-induced EPS was lower than that induced by haloperidol (HPD) in schizophrenia patients in a double blind controlled study.3 A patient developed TD due to chronic antipsychotic treatment for more than several years, but TD was improved by a switch from RIS to APZ. Although the improvement of tardive dyskinesia by APZ has been reported, the improvement of TD has not, and so this is a valuable case. However, TD and acute dystonia induced by APZ have also been reported,4 suggesting that APZ should be carefully administered. The pathophysiological basis of tardive dystonia remains obscure. Many points remain to be elucidated with regard to the pathology of TD and the efficacy of APZ for TD. Further accumulation of cases and experience are necessary.
Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies (2013)

Topical administration is attractive and non-invasive gene delivery approach. It is simple and allows repeated administration. In addition, the skin is active immune surveillance site. Topical gene therapy, although promising for treatment of cancer, dermatological disorders, vaccination and autoimmune disease, has not progressed yet to clinical trials. The inability of nucleic acids to survive the extraand intracellular environment and to permeate through the outermost layer of the skin, the stratum corneum, compromise the therapeutic outcomes of nucleic acids-based therapies. Nanostructured vehicles (e.g. transfersomes, niosomes, nanoemulsions, gemini-lipid nanoparticles and biphasic vesicles) have the ability to partially disrupt and perturb lipids that are found in the skin layers and deliver their nucleic acid cargos to their targeted subcellular compartments. However, the efficiency of these carriers is still inferior to other invasive methods (e.g. epidermal and intradermal injections). The goal of this review is to examine the critical parameters required to enhance the efficiency of the currently available nanostructured vehicles, for example, by combining them with minimally invasive techniques, such as, electroporation, iontophoresis, microneedles, ultrasound, gene gun and femtosecond laser. The recent advances in engineering these nanovectors will be discussed with a focus on their future prospects.
Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1 (2008)

A role for microRNAs (miRNA) in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation has not been described. Here, we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3' untranslated region (3'UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nuclear protein 1 (TP53INP1). A low expression level of TP53INP1 protein was found in HTLV-1-transformed cells. Additionally, when antagomirs were used to knock down miR-93 and miR-130b in these cells, the expression of TP53INP1 was increased, suggesting that the latter is regulated inside cells by the former. A role for TP53INP1 in regulating cell growth was established by experiments that showed that enhanced TP53INP1 expression increased apoptosis. Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells.
On the Impact of Software Ecosystems in Requirements Communication and Management. (2013)

Abstract. The treatment of economic and social issues in Software Engineering was pointed out as a challenge for the next years. Companies and organizations have directly (or not) opened up their software platforms and assets to others, including partners and third-party developers around the world, generating software ecosystems (SECOs). This changes the traditional software industry because it requires mature research in software requirements and architecture in an environment where business models and socio-technical networks can impact the management of the platforms ’ needs and demands overtime. However, one strong inhibitor is the complexity in defining and modeling SECOs elements to improve their comprehension and analysis and their impacts on requirements engineering. So, this paper introduces an approach to support SECO definition and modeling based on the SECOs domain. The goal consists in dealing with the stakeholders ’ value proposition and realization in SECOs, as well as treating nontechnical issues in components and social repositories.
On the Essential Spectrum of Toeplitz Operators with Semi-Almost Periodic Symbols (2003)

The essential spectra of Toeplitz operators with piecewise continuous and almost periodic symbols admit pretty nice geometric descriptions. In contrast to this, little is known about the essential spectra of Toeplitz operators with semi-almost periodic symbols, that is, with symbols belonging to the algebra generated by the continuous functions on the real line with a jump at infinity and by the continuous almost periodic functions. A classical result by Sarason enables us to decide whether the Toeplitz operatorT(a-λ) is Fredholm for a given point a in the plane, but the problem of characterizing the set ofallλ for whichT(a -λ) is not Fredholm is nevertheless intricate. This question is studied in the present paper.
Developmental expression profile of quaking, a candidate gene for schizophrenia, and its target genes in human prefrontal cortex and hippocampus shows regional specificity (2007)

Decreased expression of oligodendrocyte/myelin-related (OMR) genes, including quaking (QKI), is a consistent finding in gene expression studies of post-mortem brain from subjects with schizophrenia, and these changes are most prominent in the hippocampus vs. the prefrontal cortex (PFC). Although expression of QKI and other OMR genes has been examined in rodents, little is known about their developmental trajectory in the human brain. Therefore, we examined expression of QKI and several putative mRNA targets of QKI in human PFC and hippocampus at different ages. The pattern of QKI expression in the PFC resembled that reported in rodents, with high QKI-5 in the fetal brain and an increase in QKI-6 and QKI-7 during the period of active myelination, although QKI-5 expression did not decrease substantially during postnatal development in the PFC in humans as it does in rodent brain. Most of the putative QKI target genes also showed linear increases in expression with increasing age in the PFC. In contrast, expression of these genes showed little evidence of developmental regulation in the hippocampus. Correlations between expression levels of the nuclear vs. cytoplasmic QKI isoforms, and putative splicing targets of the former, also differed between tissues. Thus, we speculate that a robust increase in OMR gene expression normally occurs with age in the PFC, but not in the hippocampus, which may explain why decreases in OMR gene expression in schizophrenia are more pronounced in the latter tissue. We also suggest that OMR transcripts might be processed by different splicing proteins in different tissues.
Supplement Figure 3 from Germline Variants and Advanced Colorectal Adenomas: Adenoma Prevention with Celecoxib Trial Genome-wide Association Study (2023)

&lt;p&gt;Supplement Figure 3&lt;/p&gt;
Analysis of an antijam FH acquisition scheme (1992)

An easily implemented matched filter scheme for acquiring hopping code synchronization of incoming frequency-hopping (FH) signals is analyzed, and its performance is evaluated for two types of jamming: partial-band noise jamming and partial-band multitone jamming. The system is designed to reduce jammer-induced false alarms. The system's matched filter output is compared to an adaptive threshold that is derived from a measurement of the number of acquisition channels being jammed. Example performance calculations are given for the frequency coverage of the jamming either fixed over the entire acquisition period or hopped, that is, changed for each acquisition pulse. It is shown that the jammer's optimum strategy (the worst case) is to maximize the false alarm probability without regard for the effect on detection probability, for both partial-band noise and multitone jamming. It is also shown that a significantly lower probability of false acquisition results from using an adaptive matched filter threshold, demonstrating that the strategy studied here is superior to conventional nonadaptive threshold schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
LIQUID HYDROCARBON FUELS FROM BIOMASS (1989)

Renewable resources can provide a substantial energy resource for the United States. The direct production of liquid fuels from renewable resources, however, is limited to the use of biofuels. Liquids are preferred for use as
Conformable and scalable tactile sensor skin for curved surfaces (2006)

We present the design and realization of a conformable tactile sensor skin (patent pending). The skin is organized as a network of self-contained modules consisting of tiny pressure-sensitive elements which communicate through a serial bus. By adding or removing modules it is possible to adjust the area covered by the skin as well as the number (and density) of tactile elements. The skin is therefore highly modular and thus intrinsically scalable. Moreover, because the substrate on which the modules are mounted is sufficiently pliable to be folded and stiff enough to be cut, it is possible to freely distribute the individual tactile elements. A tactile skin composed of multiple modules can also be installed on curved surfaces. Due to their easy configurability we call our sensors "cut-and-paste tactile sensors." We describe a prototype implementation of the skin on a humanoid robot
Acrolein Application to Mitigate Biogenic Sulfides and Remediate Injection Well Damage in a Gas Plant Water Disposal System (2005)

Abstract The unique and reactive chemistry of acrolein enables a 3-fold approach to oilfield problems stemming from sulfate reducing bacteria (SRB): 1) it is an effective biocide, 2) it scavenges H2S, and 3) it dissolves iron sulfide. In this study, the utility of acrolein for remediation of problems with SRB and biogenic sulfides in a gas plant water disposal system at an Exxon Mobil facility in Mobile Bay, Alabama is presented. The disposal system, designed to handle produced water from offshore, process water from gas plant operations, and surface water drainage within the plant, was losing capacity due to iron sulfide fouling of the surface equipment and plugging of the disposal wells. Bacterial monitoring indicated that SRB originating from the drain water had become established in the tanks and flowlines. These SRB were generating 8-10 ppm dissolved H2S that was ultimately responsible for the iron sulfide formation. The iron sulfide resulted in poor water quality (Millipore® rates=200-300 ml/5 min), tank fouling, filter plugging, injection line scaling, and loss of injectivity due to near well bore damage in the disposal wells. The treatment design consisted of 1) initial remediation of injection wells by acrolein squeeze stimulations using a coiled tubing unit, 2) removal of iron sulfide pads from the tankage and iron sulfide build up in the disposal lines, and mitigation of SRB populations via batch treatments with acrolein, and 3) preventive maintenance using a continuous and batch treatment program with acrolein. Immediately following squeeze treatment of the disposal wells, a 30% increase in capacity was observed. The topside treatment program has resulted in a 400 to 500% improvement in Millipore® rates, decreased levels of SRB, greater than 90% decrease in soluble H2S and a 65% decrease in filter replacements. Overall benefits of the program include acceptable injection rates and pressures and reduced operating costs through decreased filter changes, remedial expenses to maintain the disposal wells, and water trucking expenses.
ChemInform Abstract: Macrocycles Containing Tin. Preparation of Macrobicyclic Lewis Acidic Hosts Containing Two Tin Atoms and 119Sn NMR Studies of Their Chloride and Bromide Binding Properties in Solution. (1990)

Abstract The tricyclic distannanes (V) are prepared via phenyl halogen exchange and bridging with the α,ω‐di(bromomagnesium)alkanes (III) as outlined in the reaction scheme.
Charakterisierung von Antikörpern gegen das Pyroglutamat-3-Amyloid-beta Peptid (AβpE3-Peptid) als Voraussetzung für eine potentielle Anwendung in der Alzheimer Immuntherapie (2017)

Die Alzheimer Erkrankung (AD) beeinträchtigt mehr als 30 Mio. Menschen weltweit. Histopathologisch ist sie unteranderem charakterisiert durch die extrazelluläre Ablagerung des Amyloid-beta Peptids (Aβ) im Gehirn. Passive Immunisierungen mit der Verwendung von Antikörpern (AK) gegen das Aβ-Peptid zeigten erste Behandlungserfolge. Bisher wurde eine Vielzahl von verschiedenen Aβ-Varianten in Gehirnen von AD-Patienten identifiziert. Zu einer der modifizierten Aβ-Varianten gehört das Pyroglutamat-3-Aβ Peptid (AβpE3), welches toxischere Eigenschaften im Vergleich zum nicht-modifiziertem Aβ-Peptid besitzt. Drei in dieser Arbeit charakterisierten AβpE3-spezifischen AK zeigen eine hohe Affinität gegenüber dem AβpE3-Peptid und inhibieren die Aggregation der AβpE3-Peptide unter in-vitro-Bedingungen. Anhand der strukturellen Charakterisierung mittels Röntgenkristallographie konnte gezeigt werden, dass diese AK andere Bindungsmodi aufweisen als die bisher veröffentlichten Aβ-spezifischen AK. Die tiefe Einbuchtung für die Bindung des hydrophoben AβpE3-N-terminus könnte ein bevorzugtes Gerüst für die Entwicklung von Immuntherapeutika repräsentieren. Zudem konnte eine strukturelle Besonderheit des AβpE3-N-Terminus beobachtet werden.
IgD Multiple Myeloma (1975)

One hundred thirty-three patients had IgD myeloma. The IgD comprises 0.8% of M-components in general and 2.1% of myelomas in particular. Males predominate and 65% of the patients are younger than 60 years at the diagnosis. More than half of the patients have lymphadenopathy, hepatomegaly, or splenomegaly. Extraosseous spread and amyloidosis are frequent. Severe anemia and azotemia are common. Total serum protein and IgD M-component levels are usually not high. LAMBDA-type light chains are found in 90% of IgD M-components. Bence Jones proteinimia is frequent and Bence Jones proteinuria appears in almost all patients. Mean survival is 13.7 months from diagnosis. The IgD is different from IgG and IgA myeloma, indicating that the clinical picture and course of multiple cyeloma may be related to the class and type of M-component.
Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET (2019)

<b>Purpose:</b> Increased incidence of depression in HIV+ patients is associated with lower adherence to treatment and increased morbidity/mortality. One possible underlying pathophysiology is serotonergic dysfunction. In this study, we used an animal model of HIV, the SIV-infected macaque, to longitudinally image serotonin transporter (SERT) expression before and after inoculation, using 11C-DASB (SERT ligand) PET imaging. <b>Methods:</b> We infected seven rhesus macaques with a neurovirulent SIV strain and imaged them at baseline and multiple time points after inoculation (group A). Pyrosequencing methylation analysis of the SERT promoter region was performed. We also measured SERT mRNA/protein in brain single-cell suspensions from another group (group B) of SIV-infected animals (n = 13). <b>Results:</b> Despite some animals showing early fluctuations, 86% of our group A animals eventually showed a net increase in midbrain/thalamus binding potential (BP<sub>ND</sub>) over the course of their disease (mean increased binding between last time point and baseline = 30.2% and 32.2%, respectively). Repeated-measures mixed-model analysis showed infection duration to be predictive of midbrain BP<sub>ND</sub> (p = 0.039). Thalamic BP<sub>ND</sub> was statistically significantly associated with multiple CSF cytokines (P < 0.05). There was higher SERT protein levels in the second group (group B) of SIV-infected animals with SIV encephalitis (SIVE) compared to those without SIVE (p = 0.014). There were no longitudinal changes in SERT gene promoter region percentage methylation between baselines and last time points in group A animals. <b>Conclusion:</b> Upregulated SERT leading to lower synaptic levels of serotonin is a possible mechanism of depression in HIV+ patients, and extrapolating our conclusions from SIV to HIV should be sought using translational human studies.
Comments on the Transformation of Amorphous Boron Nitride to a Tubular Morphology (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommentsNEXTComments on the Transformation of Amorphous Boron Nitride to a Tubular MorphologyEwan J. M. Hamilton, Edwin P. Boyd, and Sheldon G. ShoreView Author Information Department of Chemistry, The Ohio State University, Columbus, Ohio 43210 Cite this: Chem. Mater. 2001, 13, 4, 1428Publication Date (Web):March 10, 2001Publication History Received9 January 2001Revised12 February 2001Published online10 March 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/cm012000jhttps://doi.org/10.1021/cm012000jarticle-commentaryACS PublicationsCopyright © 2001 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views268Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (11 KB) Get e-AlertscloseSUBJECTS:Chemical vapor deposition,Crystallization,Genetics,Morphology,Nitrides Get e-Alerts