gebhart/patrepeval huggingface dataset:
Facile one-pot synthesis of new annulated hexacyclic ring system indeno-pyrano-furo-indoles and spiro indenopyran-indoles under microwave irradiation (2009)

An efficient and clean procedure for the synthesis of a new hexacyclic system indeno-pyrano-furo-indoles 8 and spiroindoles incorporating pentacyclic ring system spiro[indenopyran-indoles] 6 using inorganic solid support under microwave irradiation is described.
<p>Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium</p> (2019)

<i>TLR4</i> and <i>MMP13</i> expression were elevated in the synovium of osteoarthritis patients with high HbA1c concentrations. Our results may provide insight into the pathology of OA patients with DM.
Synthesis of Extracellular Matrix and Adhesion Through β 1 Integrins Are Critical for Fetal Ventricular Myocyte Proliferation (2000)

Extracellular matrix (ECM) regulates vascular smooth muscle cell proliferation. The role of ECM in myocardial growth is unexplored. We sought to determine whether human fetal ventricular myocytes (HFVMs) produce ECM and whether synthesis and attachment to ECM are necessary for their epidermal growth factor (EGF)-dependent and -independent proliferation. Cultured HFVMs proliferate in the presence but not absence of serum and EGF, as determined by increase in cell number and [(3)H]thymidine and [(14)C]leucine incorporation (measures of DNA and protein synthesis, respectively). Using a cyanogen bromide digestion technique to measure collagen and elastin and using affinity chromatography for fibronectin, we found that HFVMs synthesized collagen and fibronectin but not elastin. HFVMs grown on exogenous ECM (including fibronectin and type I collagen and laminin) demonstrated no change in proliferation or DNA and protein synthesis with or without EGF. However, inhibition of collagen synthesis using cis-4-hydroxyproline resulted in a decrease in EGF-related HFVM proliferation and DNA and protein synthesis, which was reversed by exposure to L-proline but not by growth on type I collagen. Use of beta(1) but not beta(3) integrin antibody to inhibit cell interaction with ECM resulted in a decrease in HFVM proliferation and DNA and protein synthesis in response to EGF. Furthermore, EGF-dependent proliferation was enhanced by alpha(1)beta(1) and alpha(5)beta(1) antibodies that act as functional ligands, but not alpha(3)beta(1), the only beta(1) subtype expressed in adult myocytes. In conclusion, proliferating HFVMs synthesize collagen and fibronectin. The proliferative response of HFVMs to EGF requires the synthesis of collagen as well as attachment to specific alpha/beta(1) integrin heterodimers.
Evaluation of shear anisotropy from sonic and borehole seismic measurements in the Cuitlahuac Field, Mexico (2006)

Shear waves propagate through rocks with different velocities in different directions. This phenomenon is called acoustic anisotropy, and it is caused by the anisotropic nature of the rocks' elastic properties. All sedimentary rocks exhibit some degree of acoustic anisotropy related to aligned fractures, layering or stress imbalance. In a formation with one set of dominant fractures, the horizontal sections of these fractures tend to coincide with the direction of principal horizontal stress, and the direction perpendicular to the fractures tends to coincide with the direction of minimum horizontal stress. A dominant stress direction or a set of parallel vertical fractures causes vertically propagating shear waves to split into a fast component, with particle motion along the direction of maximum stress or parallel to the fracture planes, and a slow component, with particle motion along the direction of minimum stress (Alford, 1986). Crossed‐dipole sonic logging tools measure shear‐wave anisotropy in the formation. The anisotropic nature of the formation yields important new information for drilling and completion engineering as well as geophysics and petrophysics. Similar to the use of crossed‐dipole sonic measurements, borehole shear seismic measurements can also be used to measure shear anisotropy by exciting two orthogonally polarized shear waves at the surface and measuring their propagation along the borehole with multicomponent geophones. The dipole sonic measurements are made every 0.5 ft at frequencies of about 3 kHz and the seismic measurements are made at 50‐ft intervals at frequencies of about 40 Hz. Compared with the seismic measurements, the sonic measurements are localized. On the other hand, although seismic measurements are made over total intervals from about 600 ft to several thousands of feet, they can measure a very small effective anisotropy. Until recently wireline sonic tools were able to reliably measure the anisotropy magnitude and orientation only if the velocity anisotropy was greater than 5%. A new modular sonic tool is able to measure anisotropy as low as 1% (Wielemaker et al., 2005). In this paper, we will present evidence for weak acoustic anisotropy in a Pemex well in Reynosa, Mexico. Two different mechanisms of anisotropy, which differ in magnitude and direction, are identified from sonic measurements. The anisotropies identified by sonic measurements are confirmed by the borehole shear seismic measurements
Design of a high-efficiency power converter for a satellite solid-state power amplifier (2002)

The design of a high-efficiency electronic power converter (EPC) for a satellite C-Band solid-state power amplifier (SSPA) is presented. The EPC provides +9 V to the SSPA drain at a maximum power level of +55 W and -3 V for the SSPA gate bias at a power level of 0.15 W. Ultra-high efficiency is achieved by employing an active clamp forward power converter and synchronous rectifiers. Experimental results show an efficiency in excess of 94%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Larotrectinib (laro) long-term efficacy and safety in patients (pts) with tropomyosin receptor kinase (TRK) fusion thyroid carcinoma (TC). (2023)

6091 Background: Neurotrophic tyrosine receptor kinase ( NTRK) gene fusions are oncogenic drivers in a variety of tumor types, including TC. Laro is a first-in-class, highly selective, central nervous system (CNS)-active TRK inhibitor approved for tumor-agnostic use in pts with TRK fusion cancer based on a rapid, robust, and durable objective response rate (ORR) in both adult and pediatric pts with various cancers. Here, we report data on the subset of pts with TRK fusion TC treated with larotrectinib with long-term follow-up. Methods: Pts with TRK fusion TC enrolled in three laro clinical trials (NCT02576431, NCT02122913, NCT02637687) were included. Laro was administered at 100 mg twice daily to most pts; two pediatric pts received 100 mg/m 2 . Responses were assessed per independent review committee (IRC) using RECIST v1.1. Data cut-off: July 20, 2022. Results: As of data cut-off, 30 pts were eligible for efficacy assessment by IRC. The median age was 61.5 years (range 6–80) and the median time since initial cancer diagnosis was 5.0 years (range 0–46). The gene fusions involved NTRK1 (n =14; 47%) or NTRK3 (n =16; 53%). Fifteen pts (50%) received no prior systemic therapies, and six (20%) received ≥2; 23 (77%) received prior radioiodine. ORR was 63% (95% confidence interval [CI] 44–80): three (10%) complete response, 16 (53%) partial response (PR), five (17%) stable disease, four (13%) progressive disease, and two (7%) not evaluable. For pts classified as differentiated TC (DTC; n = 23), the ORR was 78% (95% CI 56–93). For pts classified as anaplastic TC (ATC; n = 7), the ORR was 14% (95% CI 0–58). All four pts with CNS metastases at baseline had a PR. Median time to response was 1.9 months, and median duration of response (DoR) was 43.3 months (95% CI 21.6–not estimable [NE]) at a median follow-up of 32.3 months. Median progression-free survival was 35.5 months (95% CI 23.4–NE) at a median follow-up of 34.0 months. Median overall survival (OS) was not reached (NR; 95% CI 48.7–NE) at a median follow-up of 46.4 months; the 48-month OS rate was 71% (95% CI 54–88). Median OS was NR (95% CI 48.7–NE) in DTC and 8.8 months (95% CI 2.6–NE) in ATC. At data cut-off, five pts who had disease progression continued treatment for ≥4 weeks due to continued clinical benefit. Treatment-related adverse events (TRAEs) were predominantly Grade 1–2. Grade ≥3 TRAEs were reported in two (7%) pts (anemia and decreased lymphocyte count). There were no treatment discontinuations due to TRAEs. Conclusions: Laro continues to demonstrate a rapid and durable response, extended survival, and a favorable safety profile in pts with TRK fusion DTC. Limited single-agent activity was observed in ATC. These results support the wider adoption of next generation sequencing panels, which include NTRK gene fusions, in pts with advanced TC prior to the initiation of any systemic therapy. Clinical trial information: NCT02576431 , NCT02122913 , NCT02637687 .
An efficient and robust eigenvalue method for small-signal stability assessment in parallel computers (1995)

Small signal stability analysis of interconnected power systems is performed through the partial computation of the eigenvalues/eigenvectors of very large matrices. Parallel processing has already been efficiently used in this analysis. In this paper, a parallel version of the bi-iteration method and of a new hybrid method specially developed for parallel processing are introduced and their performance compared with the results obtained with the parallel lop-sided simultaneous iterations algorithm. These algorithms were implemented in an Intel iPSC/860 parallel computer with hypercubic topology. The results presented in the paper were obtained for a model of a large practical power system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Correction. Stable Carbocations. CXXXIV. Protonation of Mono- and Dihydroxybenzenes and Their Methyl Ethers in Superacids. (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. Stable Carbocations. CXXXIV. Protonation of Mono- and Dihydroxybenzenes and Their Methyl Ethers in Superacids.G Olah and Y MoCite this: J. Org. Chem. 1974, 39, 24, 3617Publication Date (Print):November 1, 1974Publication History Published online21 October 2003Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jo00938a603https://doi.org/10.1021/jo00938a603research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ALGORITHM 643 (1986)

The computer code for Mehta and Patel's (1983) network algorithm for Fisher's exact test on unordered r×c contingency tables is provided. The code is written in double precision FORTRAN 77. This code provides the fastest currently available method for executing Fisher's exact test, and is shown to be orders of magnitude superior to any other available algorithm. Many important details of data structures and implementation that have contributed crucially to the success of the network algorithm are recorded here.
Should countries be more like shopping malls? A proposal for Service Performance Guarantees (2018)

Abstract Through an examination of existing guarantee mechanisms, this article sets out and explains a proposal for the adoption of Service Performance Guarantees (SPGs) by developing countries working to attract foreign investment. The proposed approach is to offer investing firms the opportunity to purchase insurance against a wider range of risks than is currently possible, with highly visible payouts if service delivery standards fall short of those expected from the programme. The SPG contracts would be covered by a “domestic reserve” funded from premiums paid in by the firms and backed up by a further guarantee issued by a development partner. This approach restructures accountability to create a partnership of donors and recipient governments, accountable to their investor clients.
Contacter: An Enhanced Contact Application for Easy Update and Recovery of Contacts Using the Session Initiation Protocol (SIP) (2007)

This paper presents a peer-to-peer (P2P) application that extends functionality of Personal Information Manager (PIM) software installed in end user devices such as mobile phones. The application facilitates end-to-end connectivity by allowing devices to automatically request contact information from and update contact information stored in other devices. Utilizing automatic update of contact information the application also provides a method for recovery of lost contact information. The application utilizes the session initiation protocol (SIP) for establishing sessions between peer nodes making the system interoperable with IP multimedia subsystem (IMS) in cellular and fixed networks. The application can be used to support community services.
Graphdiyne-based photocatalysts for solar fuel production (2022)

This review summarizes the structure, properties, synthesis, and characterization of graphdiyne and outlines the applications of graphdiyne-based photocatalysts for solar fuel production, including H 2 evolution, CO 2 reduction, and N 2 fixation.
Gender and Leadership: an Approach to the Differences between Women and Men in Management (2014)

When a group of persons begins to interact, various differences between the members begin to appear. The pattern of relationships change according to the nature of the task and the most influential person became to be the leader. The aim of the present work is study whether men and women leader are fundamentally different or similar, reviewing the different relationships that exist when a group agrees a division of labour, roles, and responsibilities. It is also important to explore how the way of leadership influences the evolution of the whole group. Leaders must be chosen because of the characteristics that they possess. They should be seen as best suited to lead in particular situations and when negotiation and diplomacy are needed, interpersonal skills may outweigh the value of a dominant leader. In line with these, traditional feminine behaviour could be favoured in new business scenarios.
Long-time limits and occupation times for stable Fleming–Viot processes with decaying sampling rates (2020)

Dans cet article, nous introduisons et analysons une classe de processus de Fleming–Viot, avec taux d’échantillonnage décroissant et déplacement $\alpha$-stable, correspondant à des distributions de populations croissantes. Les théorèmes limites en temps long presque-sûr pour ces processus sont obtenus, répondant ainsi à la question de la distribution en temps long de la population dans le cas de populations croissantes. Les asymptotiques d’ordres supérieurs sont aussi obtenues. Les convergences des processus de temps d’occupation et d’habitation des particules sont considérées et reliées au moyen du processus historique. Les résultats et techniques autorisent des processus de Feller de déplacement/mutation généraux et peuvent s’appliquer à d’autres processus de Markov à valeurs mesures.
A nonlethal mutation in large T antigen of polyomavirus which affects viral DNA synthesis (1989)

A mutation in polyomavirus large T antigen which affects viral DNA synthesis was discovered in strain NG59RA (RA). The effect was most visible in nonpermissive cells. Although a substantial yield in DNA synthesis is normally observed in infections of Fischer rat cells when these are maintained at 33 degrees C (D.L. Hacker, K.H. Friderici, C. Priehs, S. Kalvonjian, and M.M. Fluck, p. 173-181, in R.E. Moses and W.C. Summers, ed., DNA Replication and Mutagenesis, 1988; D.L. Hacker and M.M. Fluck, Mol. Cell. Biol., in press), a 10- to 20-fold decrease in yield was obtained in infections with RA. The yield of free viral DNA in RA transformants was also strongly diminished, whether the transformants were maintained at 37 or 33 degrees C. A large reduction in the apparent number of integration sites, as well as a small reduction in the incidence of tandem integration of the viral genome, was observed in F-111 or FR-3T3 cells transformed by the mutant strain. This appears not to be directly related to the number of integration templates. A DNA fragment was identified which rescues these phenotypes. The fragment is located between the HindIII and NsiI restriction sites (nucleotides 1656 to 1910), a region which encodes only large T antigen. Sequence analysis of this region reveals a C-to-G transition at nucleotide 1791 which causes a proline-to-alanine change in the amino acid sequence of large T antigen. No other mutations have been previously reported in this region of large T antigen.
Phenylacetylene-Methyl Methacrylate Radical Copolymers (1981)

Abstract Radical copolymers of phenylacetylene (PA, M2) with methyl methacrylate (M1) can be characterized by the terminal copolymerization model with the parameters r1 = 1.07 and r2 = 0.09. By 1H-NMR spectroscopy, the predominance of transconfiguration for PA structural units and a high tendency of coisotactic placement between the aromatic and methoxy groups are evidenced. Spectral changes with the registration temperature indicate conformational isomerism.
PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application (2021)

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases.
Conservation of the genes for dissimilatory sulfite reductase from Desulfovibrio vulgaris and Archaeoglobus fulgidus allows their detection by PCR (1995)

The structural genes for dissimilatory sulfite reductase (desulfoviridin) from Desulfovibrio vulgaris Hilden-borough were cloned as a 7.2-kbp SacII DNA fragment. Nucleotide sequencing indicated the presence of a third gene, encoding a protein of only 78 amino acids, immediately downstream from the genes for the alpha and beta subunits (dsvA and dsvB). We designated this protein DsvD and the gene encoding it the dsvD gene. The alpha- and beta-subunit sequences are highly homologous to those of the dissimilatory sulfite reductase from Archaeoglobus fulgidus, a thermophilic archaeal sulfate reducer, which grows optimally at 83 degrees C. A gene with significant homology to dsvD was also found immediately downstream from the dsrAB genes of A. fulgidus. The remarkable conservation of gene arrangement and sequence across domain (bacterial versus archaeal) and physical (mesophilic versus thermophilic) boundaries indicates an essential role for DsvD in dissimilatory sulfite reduction and allowed the construction of conserved deoxyoligonucleotide primers for detection of the dissimilatory sulfite reductase genes in the environment.
Laryngeal Preservation Surgery (2007)

Patients afflicted with selected laryngeal and hypopharyngeal cancers have garnered benefit from laryngeal preservation procedures for more than a century. Billroth performed the first hemilaryngectomy for malignancy in 1874 (1). Over the ensuing decades numerous procedures evolved to afford patients the maintenance of speech and swallowing without permanent tracheostomy. In 1947, Alonso (2,3) first described the open supraglottic laryngectomy to spare the true vocal cords and arytenoids by resecting the upper portion of the thyroid cartilage with the supraglottic structures. The procedure was popularized in Europe by Bocca and in the United States by Ogura, Som, and Kirchner (4). The boundaries of resection were pushed further by Majer and Reider (5) in 1959 with the introduction of the supracricoid partial laryngectomy, which provided an alternative to total laryngectomy for patients with selected glottic and supraglottic cancers. Critical review has provided refinements in these procedures. Specific indications have been established based on an improved understanding of surgical anatomy and patterns of tumor spread that have allowed for selected ablation of laryngeal components without the need for total laryngectomy and its associated morbidity.
Siting power plants (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSiting power plantsWilliam RamsayCite this: Environ. Sci. Technol. 1977, 11, 3, 238–243Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/es60126a001https://doi.org/10.1021/es60126a001research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts