gebhart/patrepeval huggingface dataset:
Computable Lower Bounds for Deterministic Parameter Estimation (2007)

This paper is primarily tutorial in nature and presents a simple approach (norm minimization under linear constraints) for deriving computable lower bounds on the MSE of deterministic parameter estimators with a clear interpretation of the bounds. We also address the issue of lower bounds tightness in comparison with the MSE of ML estimators and their ability to predict the SNR threshold region. Last, as many practical estimation problems must be regarded as joint detection-estimation problems, we remind that the estimation performance must be conditional on detection performance, leading to the open problem of the fundamental limits of the joint detection-estimation performance.
INTRAOPERATIVE METHYLENE BLUE SENTINEL LYMPH NODE MAPPING IN COLORECTAL CANCER (2008)

Methylene blue can be used as an alternative sentinel node marker for rectal cancer (above the peritoneal reflection) and colonic cancer.
The effect of free and protected oils on the digestion of dietary carbohydrates between the mouth and duodenum of sheep (1983)

Sheep fitted with rumen and re-entrant duodenal cannulas were given diets of approximately 200 g hay and 400 g concentrate mixture alone, or supplemented daily with 40 g linseed or coconut oils free or protected with formaldehyde-casein in a 5 x 5 Latin-square arrangement. Chromic oxide paper was given as a marker at feeding time and passage to the duodenum of neutral-detergent fibre (NDF) and different sugars were estimated from the values for constituent:marker at the duodenum. Contributions of microbial carbohydrates to these flows were estimated from amounts of RNA present. The carbohydrate composition of mixed rumen bacteria from sheep rumen digesta were similar regardless of diet. Of the sugars entering the duodenum all the rhamnose and ribose and 0.51, 0.24 and 0.35 of the mannose, galactose and starch-glucose respectively, were contributed by the microbes. Virtually all the arabinose, xylose and cellulose-glucose were contributed by the diet. For sheep receiving the basal ration, coefficients of digestibility between mouth and duodenum, corrected where necessary for microbial contribution, were 0.95, 0.66, 0.67, 0.62, 0.45 and 0.51 for starch-glucose, mannose, arabinose, galactose, xylose and cellulose-glucose respectively. Corresponding values when free-oil-supplemented diets were given were 0.95, 0.55, 0.38, 0.55, 0.01 and -0.02 respectively. Values for diets supplemented with linseed oil or coconut oil did not differ significantly. Addition of protected oils to the basal feed also resulted in depressed digestibilities of dietary structural sugars but to a far lesser extent than those observed with the free oils. Apparent digestibility of NDF was altered in the same direction as those of the main structural sugars, averaging 0.50, 0.17 and 0.29 in animals receiving the basal, free-oil-supplemented or protected-oil-supplemented diets respectively. The reasons for the difference between NDF and discrete carbohydrate analytical totals are discussed.
Prevention of venous thromboembolic disease following primary total knee arthroplasty. A randomized, multicenter, open-label, parallel-group comparison of enoxaparin and warfarin. (2001)

A fixed 30-mg subcutaneous dose of enoxaparin, administered twice daily, with the first dose administered within eight hours after the completion of surgery, was significantly more effective than adjusted-dose warfarin in reducing the occurrence of asymptomatic venous thromboembolism, including proximal deep-vein thrombosis, in patients undergoing total knee arthroplasty. With the numbers available, there was no significant difference between groups with regard to the occurrence of major hemorrhagic complications; however, the rate of overall hemorrhagic complications was higher in the enoxaparin group.
Production of Hexane-1,2,5,6-tetrol from Biorenewable Levoglucosanol over Pt-WOx/TiO2 (2021)

We have investigated the synthesis of hexane-1,2,5,6-tetrol (hereafter “tetrol”) from aqueous solutions of biomass-derived levoglucosanol (hereafter “Lgol”) using a (10 wt %)Pt-(10 wt %)WOx/TiO2 catalyst in both batch and continuous flow reactors. The tetrol selectivity was over 90% with Lgol feed concentrations of 10–30 wt %. Most of the Lgol feed stereochemistry was preserved (notably 91%), with threo-Lgol (hereafter “t-Lgol”) and erythro-Lgol (hereafter “e-Lgol”) converting to (S,S)-tetrol and (S,R)-tetrol, respectively. The rate of Lgol conversion was found to be first-order in the Lgol concentration, suggesting that the catalyst surface is not saturated with Lgol. The measured reaction order for H2 was zero, which is consistent with either a mechanism involving acid-catalyzed irreversible C–O bond cleavage of Lgol followed by metal-catalyzed hydrogenation of reactive intermediates or one where all of the metal sites are saturated with H2. When the reaction was run in a continuous flow reactor, the catalyst exhibited deactivation with increasing time-on-stream but was found partially regenerable with a consecutive calcination and reduction treatment. Deactivation was concluded to be caused mainly by carbon deposition, with some W-leaching from the catalyst in the initial stages of reaction. The here demonstrated understanding of reaction kinetics and catalyst stability could facilitate the development of improved processes to produce hexane-1,2,5,6-tetrol from biomass.
Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure (2014)

Both pharmacological blockade of NCCs and their genetic titration improved cardiac autonomic balance and prevented lethal arrhythmias in a mouse model of dilated cardiomyopathy and sudden arrhythmic death. Our findings suggest that NCC blockade is a potentially useful approach to preventing sudden death in patients with heart failure.
Abstract 4591: Specific elimination of invasive and multidrug-resistant cancer cells by an antibody-drug conjugate targeting AXL (2017)

Abstract Upon therapeutic pressure, cancers commonly select for drug-resistant, invasive subpopulations with elevated expression of the receptor tyrosine kinase AXL. Besides the correlation between high AXL expression and induction of epithelial-to-mesenchymal transition, a process known to support metastasis, ample evidence also links AXL to resistance against a variety of targeted therapies, including inhibitors of the MAPK pathway in malignant melanoma and the EGFR pathway in lung cancer. AXL-107-MMAE (HuMax-AXL-ADC) is a therapeutic antibody-drug conjugate specific for AXL, containing the microtubule disrupting agent monomethyl auristatin E as the cytotoxic payload. AXL-107-MMAE was previously shown to induce potent cytotoxicity in vitro and in vivo, which was dependent expression of AXL on the cell surface. We evaluated the capacity of AXL-107-MMAE to target AXL-positive MAPK pathway inhibitor resistant tumor cells, using malignant melanoma as a clinically relevant example. First, AXL-107-MMAE was shown to induce cytotoxicity in BRAF-mutant tumor cell lines that showed AXL expression upon acquired resistance to BRAF-inhibitors. In contrast, no cytotoxicity was observed in the BRAF-inhibitor-sensitive, AXL-negative parental cell lines. In heterogeneous tumor cell cultures, treatment with a BRAF-inhibitor selected for AXL-high, MAPK pathway inhibitor-insensitive melanoma cells, which was prevented by combined BRAF-inhibitor and AXL-107-MMAE treatment. Interestingly, we observed marked AXL upregulation in biopsies obtained from patients after they developed resistance to MAPK pathway inhibitors compared to paired pre-treatment biopsies. The in vivo potential of AXL-107-MMAE in malignant melanoma was demonstrated using BRAFV600E-mutated xenograft model derived from a patient who developed resistance to the BRAF inhibitor vemurafenib in the clinic. This indicates that AXL expression levels in treatment-resistant malignant melanoma are sufficient to induce tumor regression with AXL-107-MMAE, at least in this model system. These findings merit clinical validation of the targeting of both treatment-naïve and drug-resistant cancers with AXL-107-MMAE, either alone or in combination with other targeted therapies. Citation Format: Julia Boshuizen, Louise A. Koopman, Esther C. Breij, David Satijn, Daniel Peeper, Paul W. Parren. Specific elimination of invasive and multidrug-resistant cancer cells by an antibody-drug conjugate targeting AXL [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4591. doi:10.1158/1538-7445.AM2017-4591
Laterally confined photonic crystal surface emitting laser based on monolayer tungsten disulfide operating at room temperature (2018)

We report a photonic crystal surface emitting laser using monolayer tungsten disulfide as the gain medium. The cavity design utilizes a heterostructure in the photonic crystal lattice to provide lateral confinement for a high quality factor with a compact active region. Room temperature continuous wave lasing is realized after integrating monolayer tungsten disulfide flakes onto the silicon nitride photonic crystal on quartz substrate. Highly directional, near surface normal emission has also been experimentally demonstrated.
DESIGNING COLLEGE PARKING ON A HILLSIDE (2003)

Designing and building parking structures for colleges or universities presents many challenges, but doing so on a hillside is an even greater challenge. Cabrillo Community College in Aptos, California, had a good idea of what they wanted but they also knew they didn't want any retaining walls or excavation when designing their hillside lot. The topography of the site was taken into consideration and the college's wishes were met without any extra costs. This article reviews the design and costs of building the hillside lot and includes an illustration.
Radiographic Thumb Metacarpal Subsidence Following Ligament Reconstruction With Tendon Interposition and Suture-Only Suspension Arthroplasty in the Treatment of Basal Joint Arthritis (2022)

Ligament reconstruction with tendon interposition and SSA exhibit equivalent actual and normalized trapezial heights over a greater than 6-month postoperative time course.
The Application of Microhole Technology to the Development of Coalbed Methane Resources at Remote Locations (2001)

The U. S. Department of Energy (DOE) through its Natural Gas and Oil Recovery Partnership Program with American industry, has undertaken an integrated program of development to show that the cost of obtaining subsurface information can be drastically reduced through microhole technologies specifically developed to obtain that information. Collectively termed “Microhole Drilling and Instrumentation Technology,” the program objectives include: (1) drilling shallow microholes using currently available coiled tubing technology, (2) evaluating the feasibility of drilling deep microholes, (3) miniaturization and testing of bottomhole drilling assemblies, (4) miniaturization of geophysical logging tools, and (5) incorporating emerging miniature sensor technologies in borehole seismic instrumentation packages. The development of microhole technologies is underway at the DOE’s Los Alamos National Laboratory. Microhole technology development is based on the premise that because of the historic advances in electronics and sensors, conventionaldiameter wells are no longer necessary for obtaining subsurface information. Thus, the combination of deep microholes having diameters at their terminal depth ranging from 1-1/4 to 2-3/8 inches and logging tools have a 7/8-inch-diameter will comprise a very low cost alternative to currently available technology for exploration and reservoir characterization. In collaboration with the Alaskan Department of Natural Resources, Los Alamos has examined requirements for applying microhole technology to the development of coalbed methane (CBM) resources in remote, environmentally sensitive areas. For microhole technology to be successfully used for CBM exploration, it appears that it is only necessary that existing commercial hardware and tools for coring, testing, and production be miniaturized. With regard to the use of microholes for production, significant issues remain as to whether de-watering, stimulation, and well maintenance can be successfully conducted with microholes. Note. Even though our study focuses on remote Alaska and the potential impact that microhole technology could have on the development of CBM resources there, much of our analysis applies to comparable regions of the world where the high cost of exploration and characterization precludes the development of CBM resources for local use.
63CuNQR Evidence for Spatial Variation of Hole Concentration inLa2−xSrxCuO4 (2002)

We report experimental evidence for the spatial variation of hole concentration x(hole) in the high T(c) superconductor La2-xSrxCuO4 ( 0.04 < or = x < or = 0.16) via 63Cu NQR using 63Cu isotope enriched samples. We demonstrate that the extent of the spatial variation of the local hole concentration Delta(x)hole is reflected on (63)1/T1 and deduce the temperature dependence. Delta(x)hole increases below 500-600 K, and reaches values as large as Delta(x)hole/x approximately 0.5 below approximately 150 K. We estimate the length scale of the spatial variation in x(hole) to be R(hole) greater, similar 3 nm from an analysis of the NQR spectrum.
Evaluation of recombinant human erythropoietin responsiveness by measuring erythrocyte creatine content in haemodialysis patients (2021)

Erythrocyte creatine, a useful marker of erythropoietic capacity, is a reliable marker to estimate ameliorative effectiveness of ESA in haemodialysis patients.
Fabrication of Ultra Thick Ferromagnetic Structures in Silicon (2004)

A novel fabrication process is presented to create ultra thick ferromagnetic structures in silicon. The structures are fabricated by electroforming NiFe into silicon templates patterned with deep reactive ion etching (DRIE). Thin films are deposited into photoresist molds for characterization of an electroplating cell. Results show that electroplated films with a saturation magnetization above 1.6 tesla and compositions of approximately 50/50 NiFe can be obtained through agitation of the electrolyte. Scanning electron microscopy (SEM) images show that NiFe structures embedded in a 500 μm thick silicon wafer are realized and the roughening of the mold sidewalls during the DRIE aids in adhesion of the NiFe to the silicon.
Synthesis of (−)-2-Fluoroshikimic Acid (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of (−)-2-Fluoroshikimic AcidRobert H. Rich and Paul A. BartlettView Author Information Department of Chemistry, University of California, Berkeley, California 94720-1460 Cite this: J. Org. Chem. 1996, 61, 11, 3916–3919Publication Date (Web):May 31, 1996Publication History Received1 December 1995Published online31 May 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo952132uhttps://doi.org/10.1021/jo952132ubrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views338Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Ethers,Ethyl groups,Mixtures,Solutions Get e-Alerts
Aerodynamic Characteristics of the Modified Combined Cycle Engines in Ejector-Jet Mode (2006)

Modifled combined cycle engine models were tested in subsonic and transonic regions to improve the aerodynamic performance and overcome the problems which were found in the previous tests with the ejector jet prototype model. Three inlet geometries and two cowl options were tested and all models successfully reduced the inlet drag comparing to that of the prototype. In a high subsonic or transonic ∞ow, the current models showed the possibility of the thrust augmentation by the ejector-jet cycle. One dimensional aerodynamic estimations were also carried out and the results were compared with the data evaluated from the pitot pressure measurements. The mass ∞ow was in good agreement and, with a slight adjustment of the parameter, the total pressure prediction method showed reasonable match with the experimental data.
A Shift in Microglial β‐Amyloid Binding in Alzheimer's Disease Is Associated with Cerebral Amyloid Angiopathy (2012)

Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) are two common pathologies associated with β-amyloid (Aβ) accumulation and inflammation in the brain; neither is well understood. The objective of this study was to evaluate human post-mortem brains from AD subjects with purely parenchymal pathology, and those with concomitant CAA (and age-matched controls) for differential expression of microglia-associated Aβ ligands thought to mediate Aβ clearance and the association of these receptors with complement activation. Homogenates of brain parenchyma and enriched microvessel fractions from occipital cortex were probed for levels of C3b, membrane attack complex (MAC), CD11b and α-2-macroglobulin and immunoprecipitation was used to immunoprecipitate (IP) CD11b complexed with C3b and Aβ. Both C3b and MAC were significantly increased in CAA compared to AD-only and controls and IP showed significantly increased CD11b/C3b complexes with Aβ in AD/CAA subjects. Confocal microscopy was used to visualize these interactions. MAC was remarkably associated with CAA-affected blood vessels compared to AD-only and control vessels. These findings are consistent with an Aβ clearance mechanism via microglial CD11b that delivers Aβ and C3b to blood vessels in AD/CAA, which leads to Aβ deposition and propagation of complement to the cytolytic MAC, possibly leading to vascular fragility.
Biochemical Functions of Ubiquitin and Ubiquitin‐like Protein Conjugation (2007)

This chapter contains sections titled: Introduction The Ubiquitin Conjugation Pathway Ubiquitin Polymers Ubiquitin Attachment Dynamics Ubls: A Typical Modification Cycle by an Atypical Set of Modifiers Some Unusual Ubl Conjugation Features Origins of the Ubiquitin System Sulfurtransferases and Ubl Activation Enzymes The E1–E2 Couple Ubiquitin-binding Domains and Ubiquitin Receptors in the Proteasome Pathway A Proteasome “Ubiquitin Receptor” A Plethora of Ubiquitin-binding Domains Ubiquitin Conjugate Adaptor Proteins Ubiquitin-binding Domains and Membrane Protein Trafficking The MVB Pathway and RNA Virus Budding Sumoylation and SUMO-binding Motifs A SUMO-binding Motif A SUMO-induced Conformational Change Interactions Between Different Sumoylated Proteins General Biochemical Functions of Protein–Protein Conjugation Negative Regulation by Ubl Conjugation Positive Regulation by Ubl Conjugation Cross-regulation by Ubls Conclusions Acknowledgments References
Über fluorhaltige Verbindungen der Elemente der V. Hauptgruppe. XI. Über die Reaktion des Antimon(V)‐chlorides mit Fluorwasserstoff (1959)

Abstract Die Reaktion zwischen SbCl 5 und HF wurde analytisch, präparativ und konduktometrisch untersucht. Bei −75°C erfolgt Auflösung von SbCl 5 in HF unter Bildung der komplexen Säure HSbCl 5 F ohne ClF‐Austausch. Oberhalb −40°C setzt die Austauschreaktion ein. Die ersten 3 Cl‐Atome werden relativ leicht ersetzt. Oberhalb 0°C erfolgt der Austausch des vorletzten Cl‐Atoms. Die Stufe HSbClF 5 wird erst bei Zimmertemperatur langsam angegriffen. Dieser letzte Fluorierungsschritt ist die Ursache für die schon von Ruff beobachtete Hemmung der Umsetzung. Die komplexen Säuren sind in HF in Form von [H 2 F][SbCl n F 6−n ] gelöst. Bei Entfernung des Fluorwasserstoffs bilden sich feste Produkte der wahrscheinlichen Konstitution [H 2 SbCl n F 6−n ] [SbCl n F 6−n ].
Latchup Paths in Bipolar Integrated Circuits (1986)

A combination of experimental techniques was used to find latchup paths in bipolar circuits. Voltage contrast scanning electron microscopy was applied as an internal probe to analyze latchup paths. Data obtained on six device types show a variety of path combinations and interactions responsible for latchup.
Genetic, molecular and functional analyses of complement factor I deficiency (2008)

Complete deficiency of complement inhibitor factor I (FI) results in secondary complement deficiency due to uncontrolled spontaneous alternative pathway activation leading to susceptibility to infections. Current genetic examination of two patients with near complete FI deficiency and three patients with no detectable serum FI and also close family members revealed homozygous or compound heterozygous mutations in several domains of FI. These mutations were introduced into recombinant FI and the resulting proteins were purified for functional studies, while transient transfection was used to analyze expression and secretion. The G170V mutation resulted in a protein that was not expressed, whereas the mutations Q232K, C237Y, S250L, I339M and H400L affected secretion. Furthermore, the C237Y and the S250L mutants did not degrade C4b and C3b as efficiently as the WT. The truncated Q336x mutant could be expressed, in vitro, but was not functional because it lacks the serine protease domain. Furthermore, this truncated FI was not detected in serum of the patient. Structural investigations using molecular modeling were performed to predict the potential impact the mutations have on FI structure. This is the first study that investigates, at the functional level, the consequences of molecular defects identified in patients with full FI deficiency.
Enabling and Assessing Trust when Cooperating with Robots in Disaster Response (EASIER) (2022)

This paper presents a conceptual overview of the EASIER project and its scope. EASIER focuses on supporting emergency forces in disaster response scenarios with a semi-autonomous mobile manipulator. Specifically, we examine the operator's trust in the system and his/her cognitive load generated by its use. We plan to address different research topics, exploring how shared autonomy, interaction design, and transparency relate to trust and cognitive load. Another goal is to develop non-invasive methods to continuously measure trust and cognitive load in the context of disaster response using a multilevel approach. This project is conducted by multiple academic partners specializing in artificial intelligence, interaction design, and psychology, as well as an industrial partner for disaster response equipment and end-users for framing the project and the experiments in real use-cases.