gebhart/patrepeval huggingface dataset:
Data from Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin (2023)

&lt;div&gt;Abstract&lt;p&gt;Insulin-like growth factor (IGF) signaling is thought to play a role in the development and progression of multiple cancer types. To date, therapeutic strategies aimed at disrupting IGF signaling have largely focused on antibodies that target the IGF-I receptor (IGF-IR). Here, we describe the pharmacologic profile of BI 836845, a fully human monoclonal antibody that utilizes an alternative approach to IGF signaling inhibition by selectively neutralizing the bioactivity of IGF ligands. Biochemical analyses of BI 836845 demonstrated high affinity to human IGF-I and IGF-II, resulting in effective inhibition of IGF-induced activation of both IGF-IR and IR-A &lt;i&gt;in vitro&lt;/i&gt;. Cross-reactivity to rodent IGFs has enabled rigorous assessment of the pharmacologic activity of BI 836845 in preclinical models. Pharmacodynamic studies in rats showed potent reduction of serum IGF bioactivity in the absence of metabolic adverse effects, leading to growth inhibition as evidenced by reduced body weight gain and tail length. Moreover, BI 836845 reduced the proliferation of human cell lines derived from different cancer types and enhanced the antitumor efficacy of rapamycin by blocking a rapamycin-induced increase in upstream signaling &lt;i&gt;in vitro&lt;/i&gt; as well as in human tumor xenograft models in nude mice. Our data suggest that BI 836845 represents a potentially more effective and tolerable approach to the inhibition of IGF signaling compared with agents that target the IGF-I receptor directly, with potential for rational combinations with other targeted agents in clinical studies. &lt;i&gt;Mol Cancer Ther; 13(2); 399–409. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
New test patterns for camera lens evaluation (1983)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Bradford Howland, "New test patterns for camera lens evaluation," Appl. Opt. 22, 1792-1793 (1983) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Preparation of a Low-Cost Digital Camera System for Remote Sensing (2008)

Off-the-shelf consumer digital cameras are convenient and user-friendly. However, the use of these cameras in remote sensing is limited because convenient methods for concurrently determining visible and near-infrared (NIR) radiation using these cameras have not been developed. Two Nikon Coolpix 4300 digital cameras were evaluated in tandem to determine the effectiveness of a cross-camera calibration procedure that would allow concurrent use of an unmodified digital camera and a NIR-sensitive digital camera without preset shutter speeds or aperture settings. The NIR-sensitive camera was modified to detect NIR radiation by replacing the internal hot mirror with a Hoya RM72 filter. Each camera was calibrated at five exposure levels using a Gretag-Macbeth ColorCheckerTM reflectance panel, and raw camera brightness values were converted to relative reflectance by exposure compensation equations. The method was tested on a series of 26 diffuse reflectance targets, which also yielded the same exposure compensation relationships. The relationship between camera channel brightness and target reflectance was nonlinear within each exposure, but sensitivity was linear between exposures. The procedure was tested on 36 cotton plots (Gossypium hirsutum) in an irrigation study in 2006. Images obtained on eight dates during the season were corrected for exposure and converted to relative reflectance values. The normalized difference vegetation index (NDVI) values from the plots were then compared with ground-based spectrometer measurements of NDVI. Corrected camera-based NDVI values were closely correlated with the spectrometer NDVI values (r2 = 0.72), suggesting that the camera system can more consistently estimate crop reflectance characteristics if exposure compensation is applied.
An innovative intervention for the treatment of cognitive impairment&ndash;Emisymmetric bilateral stimulation improves cognitive functions in Alzheimer&rsquo;s disease and mild cognitive impairment: an open-label study (2015)

This pilot study has shown EBS to be a promising, effective, and safe tool to treat cognitive impairment, in addition to the drugs presently available. Further investigations and controlled clinical trials are warranted.
Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates (2014)

We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.
[Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate]. (2003)

The purpose of this retrospective analysis was to evaluate the outcome of pentamidine isethionate treatment (4 mg/kg of Pentamidine by the intramuscular route on Days 1 and 3) of cutaneous leishmaniasis in 326 cases that occurred during an outbreak among French military personnel in French Guyana from 1998 to 1999. A great difference was found between the 205 patients treated in French Guyana (series G) and 32 patients treated at the Laveran Military Hospital in Marseille, France (series L). Failure rate, i.e. 25% in series L versus 5% in series G, was significantly correlated with the delay to treatment which was much longer in series L. Extensive rhabdomyolysis was observed in all cases tested: this side-effect has not been reported. Based on these findings and a review of the literature on pentamidine isethionate, the authors recommend prompt treatment using lower doses. Other treatment alternatives for American cutaneous leishmaniasis are also presented including two of the latest developments in the field, i.e., oral treatment using miltefosine and topical treatment using agents such as paromomycine.
A simulation-based finite capacity scheduling system (1997)

This paper describes the methodology of a finite capacity scheduling system which uses an objectoriented discrete event simulation es its engine. The scheduling system is developed as an add-on to an infinite capacity MRP system. The system was developed in partnership with a high-end case goods furniture company. The schedules generated by the simulation-based system will be used to schedule all operations and personnel on the shop floor. The simulation methodology and statistics captured are described, along with industrial results. Results for some randomly generated problems are also given.
Crystallization Behavior of Poly(3,3-bis(Ethoxymethyl) Oxetane) and Poly(3,3-bis(Azidomethyl) Oxetane), (1984)

Two crystal modifications have been found for poly (3,3-bis(ethoxymethyl) oxetane), poly(BEMO), by wide-angle x-ray powder diffraction and differential scanning calorimetry while only one modification has been found for poly(3,3-bis(azido methyl) oxetane), poly(BAMO). Melting temperatures for the two polymers were nearly the same, varying from about 70 deg C to about 90 deg C depending on the thermal treatment; higher crystallization temperatures resulted in higher melting temperatures. The equilibrium melting temperature, T sub m, was found to be 125 deg C and 128 deg C for poly(BEMO) and poly(BAMO), respectively, using the Hoffman-Weeks extrapolation procedure. Measurement of the melting point depression of poly(BEMO) and poly(BAMO) in di-butyl phthalate yielded enthalpy of fusion values of 2.25 kcal/mole and 12.8 kcal/mole, respectively. The percent crystallinity for poly(BEMO) and poly(BAMO), respectively was calculated to be 55-60% and 13-30% based on DSC and x-ray analysis.
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins (2020)

The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties of nucleic acid-based drugs, including antisense oligonucleotides (ASOs). PS-modified nucleic acid therapeutics show improved metabolic stability from nuclease-mediated degradation and exhibit enhanced interactions with plasma, cell-surface, and intracellular proteins, which facilitates their tissue distribution and cellular uptake in animals. However, little is known about the structural basis of the interactions of PS nucleic acids with proteins. Here, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, in complex with a full PS 2'-OMe DNA gapmer ASO. To our knowledge this is the first structure of a complex between a protein and fully PS nucleic acid. Each PC4 dimer comprises two DNA-binding interfaces. In the structure one interface binds the 5'-terminal 2'-OMe PS flank of the ASO, while the other interface binds the regular PS DNA central part in the opposite polarity. As a result, the ASO forms a hairpin-like structure. ASO binding also induces the formation of a dimer of dimers of PC4, which is stabilized by base pairing between homologous regions of the ASOs bound by each dimer of PC4. The protein interacts with the PS nucleic acid through a network of electrostatic and hydrophobic interactions, which provides insights into the origins for the enhanced affinity of PS for proteins. The importance of these contacts was further confirmed in a NanoBRET binding assay using a Nano luciferase tagged PC4 acting as the BRET donor, to a fluorescently conjugated ASO acting as the BRET acceptor. Overall, our results provide insights into the molecular forces that govern the interactions of PS ASOs with cellular proteins and provide a potential model for how these interactions can template protein-protein interactions causative of cellular toxicity.
Automatic Phrase Continuation from Guitar and Bass Guitar Melodies (2013)

A framework is proposed for generating interesting, musically similar variations of a given monophonic melody. The focus is on pop/rock guitar and bass guitar melodies with the aim of eventual extensions to other instruments and musical styles. It is demonstrated here how learning musical style from segmented audio data can be formulated as an unsupervised learning problem to generate a symbolic representation. A melody is first segmented into a sequence of notes using onset detection and pitch estimation. A set of hierarchical, coarse-to-fine symbolic representations of the melody is generated by clustering pitch values at multiple similarity thresholds. The variance ratio criterion is then used to select the appropriate clustering levels in the hierarchy. Note onsets are aligned with beats, considering the estimated meter of the melody, to create a sequence of symbols that represent the rhythm in terms of onsets/rests and the metrical locations of their occurrence. A joint representation based on the cross-product of the pitch cluster indices and metrical locations is used to train the prediction model, a variable-length Markov chain. The melodies generated by the model were evaluated through a questionnaire by a group of experts, and received an overall positive response.
Color-Tunable Colloidal Crystals from Soft Hydrogel Nanoparticles (2002)

The tunability of the lattice spacing of hydrogel colloidal crystals has been achieved by simply varying the water content of the microgel pellet before annealing and crystallization. The manipulation of the lattice constant of the crystals and therefore of the wavelength of the resultant Bragg peak, i.e., the color of the crystal, leads to a myriad of photonic applications.
High-density EEG of auditory steady-state responses during stimulation of basal forebrain parvalbumin neurons (2020)

We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the cortex of freely moving mice with or without optogenetic stimulation of basal forebrain parvalbumin (BF-PV) neurons, known as a subcortical hub circuit for the global workspace. The dataset of ASSRs without BF-PV stimulation (dataset 1) contains raw 36-channel EEG epochs of ASSRs elicited by 10, 20, 30, 40, and 50 Hz click trains and time stamps of stimulations. The dataset of ASSRs with BF-PV stimulation (dataset 2) contains raw 36-channel EEG epochs of 40-Hz ASSRs during BF-PV stimulation with latencies of 0, 6.25, 12.5, and 18.75 ms and time stamps of stimulations. We provide the datasets and step-by-step tutorial analysis scripts written in Python, allowing for descriptions of the event-related potentials, spectrograms, and the topography of power. We complement this experimental dataset with simulation results using a time-dependent perturbation on coupled oscillators. This publicly available dataset will be beneficial to the experimental and computational neuroscientists.
Electrostatic discharge and high current pulse characterization of epitaxial-base silicon-germanium heterojunction bipolar transistors (2002)

This paper investigates high-current and electrostatic discharge (ESD) phenomenon in pseudomorphic epitaxial-base silicon-germanium (SiGe) heterojunction bipolar transistors (HBT). Transmission line pulse (TLP) and ESD human body model (HBM) wafer-level reliability testing, failure analysis and simulation of SiGe HBT devices is completed for high-current characterization and evaluation of the ESD robustness of a BiCMOS SiGe technology.
[Radiation reactions and the possibilities for their modification in rats exposed in the area of the Chernobyl Atomic Electric Power Station]. (1992)

A study was made of some embryological, hematological, cytogenetic and biochemical characteristics in Wistar rats exposed within the Chernobyl NPP zone over a period of 30 days (the average radiation background level, 75, and at the soil surface, 115 mR/h; a cumulative dose, 57 rad/30 days, and for pregnant rats, 36 rad/20 days). The quantity of chromosome aberrations in bone marrow metaphases and the embryonal death rate were invariable; some cases of teratogenesis were, however, observed. The total number of karyocytes in the brain and the leukocyte content in the peripheral blood sometimes decreased. The changes in certain characteristics (such as the content of endogenous amines and thiols in the liver and spleen) of the endogenous radioresistance background (ERB) and the normalization of the ERB by the radioprotective agent MIGI-K were found.
Citrus Oil and MgCl2 as Antibacterial and Anti‐Inflammatory Agents (2006)

These findings suggest that a mixture of citrus oil and MgCl(2) could be used as a natural antibacterial and anti-inflammatory agent.
The family study of otitis media: Design and disease and risk factor profiles (1996)

Recurrent acute otitis media (RAOM) and chronic otitis media with effusion (COME) exhibit familial aggregation, but environmental risk factors (day care attendance, cigarette smoke exposure, and bottle feeding) are also important in their development. The Family Study of OM was designed to ascertain the RAOM/COME status of families whose children participated in Otitis Media Research Center studies between 1978 and 1984. Probands were treated with tympanostomy tubes, and had their RAOM/COME status ascertained as criteria for entry into these studies. For the Family Study of OM parents were interviewed about their otitis media and risk factor history; mothers were interviewed about their children's history, and pertinent medical records were obtained. Members of 173 families were examined with otomicroscopy and multifrequency tympanometry; 19% of parents and 32% of siblings were classified as affected, which is substantially higher than RAOM/COME rates from previous reports. Risk factor profiles differed significantly (P < .001) between parents and their children. Younger generation (adjusted odds ratio [OR] = 4.18, 95% confidence interval [Cl], 2.74, 6.36), day care attendance (OR = 1.96, 95% Cl, 1.32, 2.91) and male gender (OR = 1.42, 95% Cl, 1.03, 1.97) were significantly related to RAOM/COME using logistic regression. Analyses confirm (1) higher disease rates in families with an affected member compared to existing studies of the general population, (2) increased risk of RAOM/COME associated with known risk factors, and (3) increased risk for parents irrespective of risk factors. Additional analyses will explore competing models of disease susceptibility using genetic models and known risk factors. © 1996 Wiley-Liss, Inc.
Increasing the output of a Littman-type laser by use of an intracavity\n Faraday rotator (2005)

We present a new method of external-cavity diode laser grating stabilization\nwhich combines the high output power of the Littrow design with the fixed\noutput pointing of the Littman-Metcalf design. Our new approach utilizes a\nFaraday-effect optical isolator inside the external cavity. Experimental\ntesting and a model which describes the tuning range and optimal tuning\nparameters of the laser are described. Preliminary testing of this design has\nresulted in a short-term linewidth of 360 kHz and a side-mode suppression of 37\ndB. The laser tunes mode-hop free over 7 GHz and we predict that much larger\ntuning ranges are possible.\n
Statistical and structural approaches to filtering Internet pornography (2005)

The WWW is a major source of unintentional exposure to pornography. Current content filtering technology using blacklisting or simple keyword searching is ineffective - today's filters have many false positives and negatives, and require tedious manual updating. This study examined how content filtering of pornographic Web page text, based on structural and statistical analysis, could greatly improve accuracy. Systematic differences between pornographic and nonpornographic Web pages were found, with Bayesian classification yielding 99.1% accuracy in text classification from pornographic and non-pornographic corpora
Experimental evidence of auxetic features in seismic metamaterials: Ellipticity of seismic Rayleigh waves for subsurface architectured ground with holes (2018)

Structured soils with regular meshes of metric size holes implemented in first ten meters of the ground have been theoretically and experimentally tested under seismic disturbance this last decade. Structured soils with rigid inclusions embedded in a substratum have been also recently developed. The influence of these inclusions in the ground can be characterized in different ways: redistribution of energy within the network with focusing effects for seismic metamaterials, wave reflection, frequency filtering, reduction of the amplitude of seismic signal energy, etc. Here we first provide some time-domain analysis of the flat lens effect in conjunction with some form of external cloaking of Rayleigh waves and then we experimentally show the effect of a finite mesh of cylindrical holes on the ellipticity of the surface Rayleigh waves at the level of the Earth's surface. Orbital diagrams in time domain are drawn for the surface particle's velocity in vertical (x,z) and horizontal (x,y) planes. These results enable us to observe that the mesh of holes locally creates a tilt of the axes of the ellipse and changes the direction of particle movement. Interestingly, changes of Rayleigh waves ellipticity can be interpreted as changes of an effective Poisson ratio. However, the proximity of the source is also important to explain the shape of the ellipses. We analyze these observations in terms of wave mode conversions inside the mesh and we propose to broaden the discussion on the complexity of seismic wave phenomena in structured soils such as soils foundations and on the coupling effects specific to the soil-structure interaction.
Intent or Gross Negligence: Hillary Clinton Should Be Charged Under 18 U.S.C. § 793 for Mishandling Classified Information (2018)

The Department of Justice failed to pursue justice when it decided not to file charges against Hillary Clinton regarding her private e-mail server. Congress created a statute that encompasses the mishandling of classified information through both willful intent and gross negligence to hold government officials to the oath they swore, which is to protect our nation’s secrets. Hillary Clinton’s acts were precisely what Congress intended to curb, and the lack of charges reveals a hole in our justice system that must be filled.
309 Tumor Necrosis Factor-Inducible Gene 6 Protein: A Novel Neuroprotective Factor Against Inflammatory Developmental Brain Injury (2012)

<h3>Background and Aims</h3> An important factor of developmental brain injury is inflammation. It has been shown that tumor necrosis factor-inducible gene 6 protein (TSG-6) has anti-inflammatory effects in several inflammatory conditions. Nothing is known so far about the role of TSG-6 in the developing brain, its impact on inflammation and its therapeutic potential. <h3>Methods</h3> PCR, Western Blotting and Immunohistochemistry was performed according to standard protocols. Brain hemispheres of untreated Wistar rats (p1-p15) were evaluated under developmental aspects of TSG-6. LPS-treated rats (0.25mg/kg LPS i.p. on p3) were evaluated under pathological aspects of TSG-6. To evaluate whether exogenous rhTSG-6 reduces inflammatory-induced brain injury, newborn Wistar rats, exposed to LPS at p3, were treated with rhTSG-6 i.p. (four repetitive doses of 2.25mg/kg every 12h, first dose three hours before LPS-injection). <h3>Results</h3> Investigations of TSG-6’s developmental brain expression showed a linear increase from p1 to p15 on gene level. Additionally, different expression was detected in Cortex, Thalamus and Striatum on gene level at p6. Expression of TSG-6 after LPS treatment (0–24h) was significantly increased on gene level and tendentiously on protein level. cCaspase-3, a marker of apoptosis, showed a significant down-regulation of &gt;30% under additional TSG-6 treatment versus sole LPS exposure (n=12–14, p=0,025). <h3>Conclusions</h3> TSG-6 Expression is developmentally regulated and increased after LPS exposure. The reduction of activated Caspase-3 demonstrates the neuroprotective potential of exogenous TSG-6 administration in inflammatory-induced developmental brain injury.
Progesterone Inhibits Activation-Induced Deaminase by Binding to the Promoter (2009)

Regulation of activation-induced deaminase (AID), an essential factor in Ig diversification, can alter not only somatic hypermutation and class switch recombination (CSR), but may also influence oncogenesis. AID deaminates cytosine to uracil in the Ig locus, thereby initiating Ig diversification. Unregulated AID can induce oncogenic DNA alterations in Ig and non-Ig loci, leading to mutations, recombination, and translocations. In this study, we demonstrate that AID mRNA production in activated mouse splenic B cells can be reduced by treatment with the sex hormone progesterone. This down-regulation is independent of translation or splicing and is predominantly achieved by inhibiting transcription. During cell treatment we could detect progesterone receptor bound to the AID promoter in proximity to NF-kappaB binding. Importantly, the progesterone-induced repression was also extended to the protein level of AID and its activity on somatic hypermutation and class switch recombination.