gebhart/patrepeval huggingface dataset:
No effect of adaptive servo-ventilation (ASV) device used on outcomes in SERVE-HF (2019)

<b>Introduction:</b> Recent data suggested that different ASV devices are associated with different outcomes based on a physiological experiment in complex sleep apnoea patients with preserved ejection fraction (n=14). Due to changes in technology over time, two different ASV devices were used in the SERVE-HF study of heart failure patients with reduced ejection fraction (Cowie et al. NEJM 2015;373:1095–105). <b>Aim:</b> To compare outcomes by ASV device used in SERVE-HF (n=1325). <b>Methods:</b> Outcome data from the SERVE-HF study were retrospectively analysed based on stratification by ASV device used (AutoSet CS2 at trial start [2009], moving to AutoSet S9SC from 2011; trial end 2013). CS2 was the only device used in 2009 and 2010, and S9SC was the only device used in 2013; in 2011 and 2012 the number of patients using CS2 and S9SC was 65 and 54, and 5 and 145, respectively. Control group patients who started ASV were also included in the analysis. <b>Results:</b> There was no effect of ASV device type on the primary endpoint (left figure), the rate of cardiovascular death (right figure), or on the rate of non-cardiovascular death. No significant interactions were found between device type and the primary endpoint (p=0.572), cardiovascular death (p=0.674) or non-cardiovascular death (p=0.071). <b>Conclusion:</b> Data from the large, randomised, SERVE-HF trial did not show any differential effects of ASV on outcome based on device type.
Mass spectrometry and redox proteomics: Applications in disease (2013)

Proteomics techniques are continuously being developed to further understanding of biology and disease. Many of the pathways that are relevant to disease mechanisms rely on the identification of post-translational modifications (PTMs) such as phosphorylation, acetylation, and glycosylation. Much attention has also been focused on oxidative PTMs which include protein carbonyls, protein nitration, and the incorporation of fatty acids and advanced glycation products to amino acid side chains, amongst others. The introduction of these PTMs in the cell can occur due to the attack of reactive oxygen and nitrogen species (ROS and RNS, respectively) on proteins. ROS and RNS can be present as a result of normal metabolic processes as well as external factors such as UV radiation, disease, and environmental toxins. The imbalance of ROS and RNS with antioxidant cellular defenses leads to a state of oxidative stress, which has been implicated in many diseases. Redox proteomics techniques have been used to characterize oxidative PTMs that result as a part of normal cell signaling processes as well as oxidative stress conditions. This review highlights many of the redox proteomics techniques which are currently available for several oxidative PTMs and brings to the reader's attention the application of redox proteomics for understanding disease pathogenesis in neurodegenerative disorders and others such as cancer, kidney, and heart diseases.
Structure of West Nile Virus (2003)

West Nile virus (WNV) is found throughout Africa, Europe, Central Asia, and, most recently, in North America. The first outbreak in the United States was in New York City during the summer of 1999, and the virus subsequently spread across the United States ([ 1 ][1]). In 2002, there were 4156
A new generation of aprotic yet Brønsted acidic imidazolium salts: effect of ester/amide groups in the C-2, C-4 and C-5 on antimicrobial toxicity and biodegradation (2013)

Imidazolium Brønsted acidic catalysts substituted with ester/amides have been assessed for both antimicrobial toxicity and biodegradation. Low toxicity to a screen of 20 microbial strains (12 fungi and 8 bacteria) was demonstrated. Imidazolium salts incorporating either ester or amide groups at N-1, C-2, C-4 and C-5 did not pass the readily biodegradable test (ISO 14593). Catalyst selection based on Traffic Signal Light classification of performance, (eco)toxicity, and efficient synthesis is described.
Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2-a]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action (2022)

The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia. Classical agonists of this receptor, such as morphine, are the main targets in the treatment of both acute and chronic pain. However, the dangerous side effects, such as respiratory depression or addiction, significantly limit their widespread use. The allosteric centers of the receptors exhibit large structural diversity within particular types and even subtypes. Currently, a considerable interest is aroused by the modulation of μ-opioid receptors. The application of such a technique may result in a reduction in the dose or even discontinuation of classical opiates, thus eliminating the side effects typical of this class of drugs. Our aim is to obtain a series of 1-aryl-5,6(1<i>H</i>)dioxo-2,3-dihydroimidazo[1,2-<i>a</i>]imidazole derivatives and provide more information about their activity and selectivity on OP3 (MOP, human mu opioid receptor). The study was based on an observation that some carbonyl derivatives of 1-aryl-2-aminoimidazoline cooperate strongly with morphine or DAMGO in sub-threshold doses, producing similar results to those of normal active doses. To elucidate the possible mechanism of such enhancement, we performed a few in vitro functional tests (involving cAMP and β-arrestin recruitment) and a radioligand binding assay on CHO-K1 cells with the expression of the OP3 receptor. One of the compounds had no orthosteric affinity or intrinsic activity, but inhibited the efficiency of DAMGO. These results allow to conclude that this compound is a negative allosteric modulator (NAM) of the human μ-opioid receptor.
Study of the Mechanical Properties of PSf/Vanillin Films. Influence of Temperature Treatments (2011)

The encapsulation method is used in the textile detergents and softeners industry to provide a long-lasting fragrance. Capsules currently employed show low encapsulation capacity and stability. However, polysulfone (PSf) microcapsules were proposed, as they show promising results. To characterize PSf capsule morphological and mechanical properties, flat sheet PSf/vanillin membranes have been prepared simulating capsules obtainment procedure. Two treatments were performed: immersing PSf/vanillin membranes in (a) 6000 ppm DMF aqueous solution or in (b) Milli-Q water, at different temperatures (55−90 °C). Membrane samples where analyzed by SEM, IFME software, and the test methods of the ASTM (puncture resistance and tensile methods). Morphological analysis showed that temperatures above 55 °C and DMF aqueous solution caused an increment of the pore number and size of the PSf/vanillin films porous layer. No structural changes were detected in the dense layer. After material treatment, only the maximum strain % of PSf/vanillin films was modified.
Identification of Botanical Biomarkers in Argentinean Diplotaxis Honeys: Flavonoids and Glucosinolates (2010)

To select and establish floral biomarkers of the botanical origin of Diplotaxis tenuifolia honeys, the flavonoids and glucosinolates present in bee-deposited nectar collected from hive combs (unripe honey) and mature honey from the same hives fron which the unripe honey samples were collected were analyzed by LC-UV-PAD-ESI-MS(n). Glycosidic conjugates of the flavonols quercetin, kaempferol, and isorhamnetin were detected and characterized in unripe honey. D. tenuifolia mature honeys contained the aglycones kaempferol, quercetin, and isorhamnetin. The differences between the phenolic profiles of mature honey and freshly deposited honey could be due to hydrolytic enzymatic activities. Aliphatic and indole glucososinolates were analyzed in unripe and mature honeys, this being the first report of the detection and characterization of glucosinolates as honey constituents. Moreover, these honey samples contained different amounts of propolis-derived flavonoid aglycones (1765-3171 μg/100 g) and hydroxycinnamic acid derivatives (29-1514 μg/100 g). Propolis flavonoids were already present in the freshly deposited nectar, showing that the incorporation of these compounds to honey occurs at the early steps of honey production. The flavonoids quercetin, kaempferol, and isorhamnetin and the glucosinolates detected in the samples could be used as complementary biomarkers for the determination of the floral origin of Argentinean Diplotaxis honeys.
Synthesis, Crystal Structure, Optical Properties and Stability of New Bismuth‐Based Organic‐Inorganic Compounds (C 6 H 9 N 2 ) a Bi b X c (X=Cl, Br, I) (2021)

Abstract We report a series of high‐quality, low‐dimension, and bismuth‐based organic‐inorganic hybrid single crystals (C 6 H 9 N 2 ) a Bi b X c (X=Cl, Br, I) fabricated via a simple hydrothermal method. The crystal structure, intermolecular interactions, morphology, chemical groups, bond characterization, and optical and thermal stability of the samples were detailed via X‐ray single crystal diffractomete, Hirshfeld surface analysis, field scanning electron microscopy (FSEM), fourier transform infrared spectrometer (FTIR), Raman, thermal gravimetric (TG), and Ultraviolet‐visible (UV‐vis) diffuse reflectance spectra. The results indicated that the (C 6 H 9 N 2 ) 2 BiCl 5 and (C 6 H 9 N 2 ) 2 BiBr 5 crystals displayed a monoclinic system with a P21/n space group at room temperature; the (C 6 H 9 N 2 )BiI 4 crystal was P21/c. Meanwhile, the band gap could be continuously adjusted between 3.2 eV and 1.6 eV via the nature of halide ligands. The samples also have good thermal stability. The starting decomposition temperature of (C 6 H 9 N 2 ) 2 BiCl 5 , (C 6 H 9 N 2 ) 2 BiBr 5 , and (C 6 H 9 N 2 )BiI 4 were 200 °C, 250 °C, and 300 °C, respectively. Therefore, this kind of organic‐inorganic hybrid compounds will be assumed to be a promising candidate for optical and electronic applications.
Supplementary Figures from Characterization of Endogenous Human Promyelocytic Leukemia Isoforms (2023)

Supplementary Figures from Characterization of Endogenous Human Promyelocytic Leukemia Isoforms
Holographic Microscopy with Acoustic Modulation for Detection of Nano-sized Particles and Pathogens in Solution (2019)

We present a method for the detection of nanoparticles in solution using an acoustically actuated holographic microscope. This type of microscopy can be used for high-throughput biosensing applications, e.g., detection of viruses in a liquid.
Superconducting Electron Linac Concepts for Molybdenum-99 Production (2014)

high-pressure helium in the target and is only cooled on one side by the helium flow. Because the window is continuously under stress from the helium pressure and the heat from the electron beam, it is desirable to estimate a lifetime for the window and develop a replacement schedule for the target holder. Such an estimate requires the ability to predict changes in the window material properties under electron irradiation. Candidate materials for the Mo-99 production target window are Inconel 718, 250 maraging steel, and beryllium. These materials encompass a wide range of thermal conductivity, thermal expansion coefficients, Young’s modulus, tensile strength and tensile ductility. The Mo-99 target window is subjected to internal pressure from the helium coolant and thermal stresses. The operating conditions and relative advantages of each material have been described previously [1]. The current work investigates the effects of electron irradiation on the tensile properties of these materials. Axial tensile tests were conducted with electron-irradiated samples and results were compared to baseline results generated for as-fabricated materials.
Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity (2018)

The cattle tick <i>Rhipicephalus microplus</i> is one of the most important ectoparasites causing significant economic losses for the cattle industry. The major tool of control is reducing the number of ticks, applying acaricides in cattle. However, overuse has led to selection of resistant populations of <i>R. microplus</i> to most of these products, some even to more than one active principle. Thus, exploration for new molecules with acaricidal activity in <i>R. microplus</i> has become necessary. Triosephosphate isomerase (TIM) is an essential enzyme in <i>R. microplus</i> metabolism and could be an interesting target for the development of new methods for tick control. In this work, we screened 227 compounds, from our in-house chemo-library, against TIM from <i>R. microplus</i>. Four compounds (<b>50</b>, <b>98</b>, <b>14</b>, and <b>161</b>) selectively inhibited this enzyme with IC<sub>50</sub> values between 25 and 50 μM. They were also able to diminish cellular viability of BME26 embryonic cells by more than 50% at 50 μM. A molecular docking study showed that the compounds bind in different regions of the protein; compound <b>14</b> interacts with the dimer interface. Furthermore, compound <b>14</b> affected the survival of partially engorged females, fed artificially, using the capillary technique. This molecule is simple, easy to produce, and important biological data-including toxicological information-are available for it. Our results imply a promising role for compound <b>14</b> as a prototype for development of a new acaricidal involving selective TIM inhibition.
Fast Parallel Recovery of Many Small In-Memory Objects (2017)

Social media networks as well as online graph analytics operate on large-scale graphs with millions of vertices, even billions in some cases. Low-latency access is essential, but caching suffers from the mostly irregular access patterns of the aforementioned application domains. Hence, distributed in-memory systems are proposed keeping all data always in memory. These in-memory systems are typically not optimized for the sheer amounts of small data objects, which demands new concepts regarding the local and global data management as well as for the fault-tolerance mechanisms to mask server failures and power outages. In this paper, we propose a novel backup distribution and parallel recovery approach aiming at fast recovery of servers storing hundreds of millions of small objects. All proposed concepts have been implemented within the open source distributed system DXRAM and have been evaluated in the Microsoft Azure cloud with up to 72 high performance virtual machines in two scale-sets. For evaluation, we used two benchmarks: the Yahoo! Cloud Serving Benchmark and a recovery benchmark. The experiments show that the proposed recovery strategy is able to recover servers with 500,000,000 small data objects in less than 2 seconds and, also, to efficiently mask server failures under heavy load. Furthermore, DXRAM outperforms the state-of-the-art system RAMCloud in additional recovery experiments with large objects (2.4× faster) and even more with small objects (> 9×).
Two-Pass Softmax Algorithm (2020)

The softmax (also called softargmax) function is widely used in machine learning models to normalize real-valued scores into a probability distribution. To avoid floating-point overflow, the softmax function is conventionally implemented in three passes: the first pass to compute the normalization constant, and two other passes to compute outputs from normalized inputs. We analyze two variants of the Three-Pass algorithm and demonstrate that in a well-optimized implementation on HPC-class processors performance of all three passes is limited by memory bandwidth.We then present a novel algorithm for softmax computation in just two passes. The proposed Two-Pass algorithm avoids both numerical overflow and the extra normalization pass by employing an exotic representation for intermediate values, where each value is represented as a pair of floating-point numbers: one representing the “mantissa” and another representing the “exponent”.Performance evaluation demonstrates that on out-of-cache inputs on an Intel Skylake-X processor the new Two-Pass algorithm outperforms the traditional Three-Pass algorithm by up to 28% in AVX512 implementation, and by up to 18% in AVX2 implementation. The proposed Two-Pass algorithm also outperforms the traditional Three-Pass algorithm on Intel Broadwell and AMD Zen 2 processors.
A Coarse-to-Fine Control Strategy for Stereo and Motion on a (1986)

USING IMAGE REPRESENTATIONS OF MULTIPLE SPATIAL SCALE AS PART OF A COARSE-TO-FINE CONTROL STRATEGY HAS PROVEN EXTREMELY USEFUL IN SOLVING THE CORRESPONDENCE PROBLEM INHERENT IN STEREO AND MOTION. UNFORTUNATELY, EXE- CUTION TIMES OF EXISTING IMPLEMENTATIONS ON SEQUENTIAL MACHINES FALL SUB- STANTIALLY SHORT OF REAL-TIME PERFORMANCE. THE UTILITY OF SUCH ALGORITHMS WOULD BE GREATLY INCREASED IF IT COULD BE SHOWN THAT THEY CAN BE IMPLEMENT- ED IN PARALLEL WITHOUT PLACING UNREALISTIC DEMANDS ON RESOURCES OF SPACE AND CONNECTIVITY. BY REQUIRING THAT THE CONTROL STRATEGY TAKE OPPORTUNIS- TIC ADVANTAGE OF A SIMPLE UNIFORM VERGENCE MOVEMENT, THE SPACE AND CONNECT- IVITY REQUIREMENTS OF THESE HIERARCHIAL ALGORITHMS ARE DRASTICALLY REDUCED. WE PRESENT DESCRIPTIONS OF TWO DIFFERENT HIERARCHIAL ALGORITHMS THAT ARE DESIGNED FOR A SIMPLE MESH-CONNECTED COMPUTER. THE FIRST IS A MESH-COMPUTER IMPLEMENTATION OF A MARR-POGGIO-GRIMSON STEREO MATCHER WHICH RUNS IN O(O LOG O) TIME. THE SECOND IS A MESH-COMPUTER IMPLEMENTATION OF A MOTION CORRESPONDENCE ALGORITHM WHICH USES A CORRELATION BASED TECHNIQUE, REQUIR- ING ONLY O(O~2LOG O) TIME.
Abstract 71: Melanoma alters the bone marrow immune composition in an age-related manner (2023)

Abstract Melanoma accounts for the most skin cancer-related deaths in the United States. As patients age, anti-tumor responses decline, making age a negative independent prognostic factor of overall survival in melanoma. Despite advances in immunotherapeutic modalities, there remains a subset of patients who do not benefit from these treatments. Understanding cancer and age-related changes to immune cell development in the bone marrow can improve patient outcomes. We hypothesize that during aging, the bone marrow niche is reshaped, driving precursor cells to become immunosuppressive. This ultimately decreases the anti-tumor response to melanoma due to the skewing of hematopoiesis to yield decreased immune function. In order to tackle this hypothesis, flow cytometry was used to analyze immune compositional changes in the bone marrow of mice challenged with melanoma. Our preliminary data suggests that when melanoma is present in the skin, there are changes to the bone marrow niche, such as an increase in total myeloid cells. Specifically, in the bone marrow of aged tumor-bearing mice, we see a decrease in Ly6C+Ly6G+ granulocytic progenitor cells and an increase in Ly6C+Ly6G- monocytic progenitor cells compared to the bone marrow of young tumor-bearing mice. We predict that the secretome of the aged bone marrow niche will impact immune cell development by producing more immature myeloid cells that can travel to the tumor site. We also saw an increase in the proportion of CD4+ T-cells in the aged bone marrow when melanoma is present. Thus, there appears to be a shift in cell populations in the aged bone marrow niche when the mice are burdened with melanoma. As a future direction, we plan to investigate the role of the aged bone marrow niche and its secretome on the effectiveness of immunotherapies, such as anti-PD-1. These insights could lead to improved outcomes for elderly patients with melanoma. Citation Format: Alexis Erasta Carey, Yash Chhabra, Ethan Black, Murilo Ramos Rocha, Mitchell Fane, Vania Wang, Daniel Zabransky, Gloria Bravante, Laura Hueser, Ashani Weeraratna. Melanoma alters the bone marrow immune composition in an age-related manner [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 71.
Use of Ciprofloxacin in the Treatment of Pseudomonas aeruginosa Infections (1986)

The therapeutic efficacy and safety of ciprofloxacin was studied in 30 patients with Pseudomonas aeruginosa infections. In 20 patients ciprofloxacin was given alone and in 10 patients (including 8 compromized hosts) in combination with an aminoglycoside (9) or azlocillin (1). Ciprofloxacin was given in doses of 500 mg orally or 200–300 mg i. v. every 12 h. In patients receiving only ciprofloxacin clinical cure with eradication of bacteria was obtained in 15 patients (75%) with infections of bone and joint (6), skin and soft tissue (4), lung (2), middle ear (2) and CSF (1). Two patients with lymphoma and Pseudomonas aeruginosa pneumonia died. In patients receiving combination therapy a definite therapeutic success was achieved in four (40%). Three patients with Pseudomonas aeruginosa septicemia died. In seven patients nine bacterial strains with decreasing susceptibility of ciprofloxacin (increase in MIC from ≤ 0.5 μg/ml to 2–16 pg/ml) were selected (6 Pseudomonas aeruginosa, 1 Enterobacter cloacae, 1 Serratia marcescens, 1 Staphylococcus aureus). Ciprofloxacin was well tolerated. This new quinolone seems to be suitable for single drug treatment of Pseudomonas aeruginosa infections in patients with normal host defense mechanisms, while its therapeutic potential in compromized hosts requires further evaluation.
Determination of selenium by gas chromatography-mass spectrometry after formation of its volatile derivative and preconcentration using vortex-assisted dispersive liquid–liquid microextraction (2023)

Vortex assisted dispersive liquid–liquid microextraction was proposed for the determination of selenium by gas chromatography-mass spectrometry after the formation of its volatile derivative with o -phenylenediamine (Se-PDA-FVD) in lake water samples.
Experimental study of p layers in ‘‘tunnel’’ junctions for high efficiency amorphous silicon alloy multijunction solar cells and modules (1994)

The role of the p layer in the formation of good quality ‘‘tunnel’’ junctions and its dependence on the attainment of high efficiency hydrogenated amorphous silicon alloy (a-Si:H) multijunction cells has been investigated. A new technique, namely, the evaluation of the current-voltage characteristics of the NIPN structure consisting of a single-junction n-i-p cell with an overlying doped n layer, has been developed for the determination of losses at the ‘‘tunnel’’ junction. Using an optimized p layer, an initial conversion efficiency of 11.4% has been obtained on a double junction a-Si:H module of aperture area ∼900 cm2.