gebhart/patrepeval huggingface dataset:
Development of a wind turbine system with energy storage in the form of hydropower (2013)

With wind energy penetration in energy markets increasing as part of the solution to meeting renewable energy targets, the need for smoothing of intermittent power generation is becoming more of a necessity. This paper looks at pumped hydro storage as a method for storing energy from the wind and shows the development of a hybrid system, where wind energy is harnessed to drive a mechanical pump to lift groundwater. The important design parameters for optimization of the system are discussed, as well as the possibility of a system that operates at 100% efficiency.
Long-Term Outcome of First-Generation Metallic Coronary Stent Implantation in Patients With Coronary Artery Disease Observational Study Over a Decade (2007)

Stabilization of the initial stented site was relatively good and the majority of cardiac events might have originated in non-target lesions. Prevention of systemic arteriosclerosis progression is important for patients with CAD, even after successful PCI.
Doping Effects of Metallic Elements on the Superconductivity in the Tl-Ba-Ca-Cu-O System (1991)

The effects of various metallic dopants on the superconductivity of the Tl-Ba-Ca-Cu-O system have been investigated. Metals (Zn, Cd, Al, In, Pb and Bi) control the rate of solid-state reaction and the volatility of Tl components. Increases in the electrical conductivity at room temperature and the superconducting volume fraction were achieved as the result of metallic doping. It is considered that metals promote the intergranular coupling of the superconductive particle and annihilate the ceramic pores in the sintering process.
Template-directed synthesis, characterization and electrical properties of Au–TiO2–Au heterojunction nanowires (2007)

The feasibility of synthesizing metal–oxide–metal (MOM) heterojunction nanowires in the Au–TiO2–Au system is demonstrated. The synthesis method presented here entails sequential electroplating of Au and electro-deposition of amorphous titanium oxide (TiOx) inside nanoholes of anodic aluminium oxide (AAO) templates. This is followed by dissolving the template, and heat-treating the released nanowires, which results in the crystallization of the amorphous TiOx segment into nanocrystalline TiO2. Detailed transmission electron microscopy (TEM) investigation has revealed that the nanocrystalline TiO2 is orthorhombic (columbite) phase primarily. This synthesis method has the potential to provide better control over the characteristics and architectures of the resulting MOM nanowires. The Au–TiO2–Au nanowires were incorporated into single-nanowire devices, fabricated using a direct-write method. Nonlinear current–voltage (I–V) responses were obtained for individual MOM nanowires. The heterojunctions in such MOM nanowires are likely to offer certain advantages over all-oxide nanowires, making the MOM nanowires potentially useful as one-dimensional building blocks in the multifunctional nanoelectronics of the future.
Optoelectronic characterization of shape and deformation of MEMS accelerometers used in transportation applications (2003)

Recent technological trends based on miniaturization of mechanical, electromechanical, and photonic devices have led to the development of microelectromechanical systems (MEMS). Effective development of MEMS requires the synergism of advanced design, analysis, and fabrication methodologies, with quantitative metrology techniques for characterization of their performance, reliability, and integrity. We describe optoelectronic techniques for measuring, with submicrometer accuracy, shape and changes in states of deformation of MEMS accelerometers used in transportation applications. Using the display and data modes of the described optoelectronic techniques, it is possible to characterize MEMS. This characterization is performed during static and dynamic modes of operation of MEMS. To assure high accuracy of measurements, overlapping regions, i.e., tiles, of MEMS are analyzed and the data (tiles) are patched together to represent the entire component. Preliminary results indicate that the MEMS accelerometer considered in this study deforms 1.48 μm, under the loading conditions used, which represents nearly 50% of its functional dimension in the direction of deformation.
A cooperative approach for dynamic spectrum access in radar bands (2014)

The considerable amount of spectrum reserved for but underutilized by radar systems has motivated several regulatory bodies to make Dynamic Spectrum Access (DSA) in radar bands a reality. Taking into account the incumbents' very long ranges, one of the main issues of DSA in these bands is the aggregate interference, derived from multiple secondary users (SUs) operating in the same channel. In this paper, we assess the impact of this phenomenon when spectrum sharing is performed in a totally opportunistic manner, for instance, when Dynamic Frequency Selection (DFS) developed by the IEEE 802.11h standard is employed, and when there is a cooperation mechanism between radar systems and SUs. We considered the operating characteristics of a real C band meteorological radar system with acceptable levels of interference standardized by the International Telecommunication Union (ITU).
Performance analysis of a MC-DS-CDMA wireless communication system with RAKE receiver over a rayleigh fading channel with receive diversity (2012)

An analytical approach is developed to derive the expression of the Multiple Access Interference (MAI) and Bit Error Rate (BER) of a MC-DS-CDMA system using multiple receiving antennas with Maximal Ratio Combining (MRC), considering Rayleigh fading channel. The analysis is extended to RAKE receiver with Equal Gain Combining (EGC). The results are presented in terms of BER and improvement of receiver sensitivity due to diversity and multicarrier orthogonal modulation. It is noticed that there are significant improvement due to diversity as well as the number of subcarriers in MC-DSCDMA system.
Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies (2020)

These findings describe a novel platform for developing patient-derived preclinical tumor models suitable for rationally testing combinatorial ICB in the context of autologous tumor-reactive T cells. This platform can be further developed for testing additional targeted therapies relevant to OVC.
Design, development and flight experiment of a small reusable rocket that glides using two-stage parachute (2011)

This paper introduces the design, development and flight result of a small reusable rocket that glides using parafoil. The mission is autonomous guidance using parafoil, because the rocket must be recovered safely at target point. In order to avoid tangling of parafoil strings, roll control using aileron is employed to keep the ejection door upward. The rocket was launched at an annual rocket launch campaign held in France. The launch and roll control were successful, however the guidance was failed because parafoil strings tangled with rocket due to opening shock. The rocket landed at 480 meters from the target point.
Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes (1996)

We have previously reported that stimulation of astrocyte cultures by particular agonists and calcium ionophores induces cyclic GMP formation through activation of a constitutive nitric oxide synthase (NOS) and that astrocytes from cerebellum show the largest response. In the present work we have used rat cerebellar astrocyteenriched primary cultures to identify and characterise the isoform of NOS expressed in these cells. The specific NOS activity in astrocyte homogenates, determined by conversion of [3H]arginine to [3H]citrulline, was ten times lower than in homogenates from cerebellar granule neurons. Upon centrifugation at 100,000 g, the astroglial activity was recovered in the supernatant, whereas in neurons around 30% of the activity remained particulate. The cytosolic NOS activities of both astrocytes and granule neurons displayed the same Km for L-arginine, dependency of calcium, and sensitivity to NOS inhibitors. Expression of NOS-I in astrocyte cytosolic fractions was revealed by Western blot with a specific polyclonal antiserum against recombinant NOS-I. Double immunofluorescence labelling using anti-glial fibrillary acidic protein (GFAP) and anti-NOS-I antibodies revealed that a minor population of the GFAP-positive cells, usually in clusters, presented a strong NOS-I immunostaining that was predominantly located around the nuclei and had a granular appearance, indicating association with the endoplasmic reticulum-Golgi system. Astrocytes of stellate morphology also showed immunoreactivity in the processes. Similar staining was observed with the avidin-biotin-peroxidase complex using different anti-NOS-I antisera. With this method the majority of cells showed a weak NOS-I immunoreactivity around the nuclei and cytosol. A similar pattern was observed with the NADPH-diaphorase reaction. These results demonstrate that the NOS-I expressed in astrocytes presents the same biochemical characteristics as the predominant neuronal isoform but may differ in intracellular location.
The Crystal Structures of Metal 8-Hydroxyquinolinate. I. Copper 8-Hydroxyquinolinate (1963)

Abstract The crystal structure of anhydrous copper 8-hydroxyquinolinate has been determined by the two-dimensional Fourier method. It is monoclinic and has been shown to belong to the B21/a space group, with eight molecules in a cell of the dimensions: a=23.66, b=8.72, c=15.30Å and β=117.5. A copper atom is surrounded by four atoms with Cu–N distances of 1.92 and 1.90Å, and Cu–O distances of 2.01 and 2.07Å. Two nitrogen and two oxygen atoms form a square and are coplanar with the copper atom. The closest approach of adjacent chelate molecules occurs along the b axis and in the [101] direction, where the interplanar distances are 3.36, 3.47, and 3.32Å. These chelate molecules are grouped in pairs around the symmetry center at the point of origin with a Cu–Cu bond of 3.45Å. The perpendicular distances between successive dimeric molecules given above are almost the same within the range of experimental error. A π-bond overlapping of molecules is considered to be a part of the binding forces between such layers. The metal-metal bond is presumably the same as that in nickel dimethylglyoxime.
Targeting CD162 protects against streptococcal M1 protein-evoked neutrophil recruitment and lung injury (2013)

Streptococcus pyogenes of the M1 serotype can cause streptococcal toxic shock syndrome and acute lung damage. CD162 is an adhesion molecule that has been reported to mediate neutrophil recruitment in acute inflammatory reactions. In this study, the purpose was to investigate the role of CD162 in M1 protein-provoked lung injury. Male C57BL/6 mice were treated with monoclonal antibody directed against CD162 or a control antibody before M1 protein challenge. Edema, neutrophil infiltration, and CXC chemokines were determined in the lung, 4 h after M1 protein administration. Fluorescence intravital microscopy was used to analyze leukocyte-endothelium interactions in the pulmonary microcirculation. Inhibition of CD162 reduced M1 protein-provoked accumulation of neutrophils, edema, and CXC chemokine formation in the lung by >54%. Moreover, immunoneutralization of CD162 abolished leukocyte rolling and firm adhesion in pulmonary venules of M1 protein-treated animals. In addition, inhibition of CD162 decreased M1 protein-induced capillary trapping of leukocytes in the lung microvasculature and improved microvascular perfusion in the lungs of M1 protein-treated animals. Our findings suggest that CD162 plays an important role in M1 protein-induced lung damage by regulating leukocyte rolling in pulmonary venules. Consequently, inhibition of CD162 attenuates M1 protein-evoked leukocyte adhesion and extravasation in the lung. Thus, our results suggest that targeting the CD162 might pave the way for novel opportunities to protect against pulmonary damage in streptococcal infections.
Dose Rate Analyses around the Equatorial and Divertor Ports during ITER In-Vessel Components Maintenance (2000)

The shutdown dose rates around the equatorial and divertor maintenance ports of ITER were evaluated with the 2-D/3-D combined approach, using the three-dimensional continuous-energy Monte Carlo code, MCNP-4B and the two-dimensional discrete ordinate code, DOT3.5. The neutron flux-to-shutdown dose rate conversion factor is derived with the two-dimensional geometry using the THIDA code system and the assumed operation scenario, i.e. the neutron fluence of 0.3 MWa/m2 in ten years of operation. The dose rate around the equatorial and divertor ports after 106 seconds (11.6 days) after reactor shutdown ranges from 100 to 200 μ Sv/h. Attempts to further reduce the dose rate by improving the shield design were made to follow the principle of ALARA.
Optical Recording Materials Based on Photoisomerization of Guest Molecules of a Polymeric Crystalline Host Phase (2005)

Norbornadiene (N) is used as an isolated guest in a host (the crystalline phase of robust syndiotactic polystyrene polymer films) and its valence photoisomerization to quadricyclane (Q) in it has been achieved. The product maintains the positional and orientational order of the reactant with respect to the polymeric crystallographic axes (see Figure).This system could be suitable for making molecular-sized units in optical data storage systems.
Nonhuman primate models for evaluation of SARS-CoV-2 vaccines (2022)

We identify several aspects of NHP models that limit their usefulness for vaccine-challenge studies and numerous variables that constrain comparisons across vaccine platforms. We propose that studies conducted in NHPs for vaccine development should use a standardized protocol and, where possible, be substituted with smaller animal models. This will ensure continued rapid progression of vaccines to clinical trials without compromising assessments of safety or efficacy.
The HNF-4/HNF-1α transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1 (1999)

Hepatocyte-specific expression of the alpha1-antitrypsin (alpha1AT) gene requires the activities of two liver-enriched transactivators, hepatocyte nuclear factors 1alpha and 4 (HNF-1alpha and HNF-4). The alpha1AT gene maps to a region of human chromosome 14q32.1 that includes a related serine protease inhibitor (serpin) gene encoding corticosteroid-binding globulin (CBG), and the chromatin organization of this approximately 130-kb region, as defined by DNase I-hypersensitive sites, has been described. Microcell transfer of human chromosome 14 from fibroblasts to rat hepatoma cells results in activation of alpha1AT and CBG transcription and chromatin reorganization of the entire locus. To assess the roles of HNF-1alpha and HNF-4 in gene activation and chromatin remodeling, we transferred human chromosome 14 from fibroblasts to rat hepatoma cell variants that are deficient in expression of HNF-1alpha and HNF-4. The variant cells failed to activate either alpha1AT or CBG transcription, and chromatin remodeling failed to occur. However, alpha1AT and CBG transcription could be rescued by transfecting the cells with expression plasmids encoding HNF-1alpha or HNF-4. In these transfectants, the chromatin structure of the entire alpha1AT/CBG locus was reorganized to an expressing cell-typical state. Thus, HNF-1alpha and HNF-4 control both chromatin structure and gene activity of two cell-specific genes within the serpin gene cluster at 14q32.1.
Observing atmospheric winds with a Doppler lidar (1991)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. Michael Hardesty, Madison J. Post, and Robert M. Banta, "Observing atmospheric winds with a Doppler lidar," Optics & Photonics News 2(10), 12-15 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-α homolog Spitz (2000)

Activation of the Drosophila epidermal growth factor receptor (DER) by the transmembrane ligand, Spitz (Spi), requires two additional transmembrane proteins, Rhomboid and Star. Genetic evidence suggests that Rhomboid and Star facilitate DER signaling by processing membrane-bound Spi (mSpi) to an active, soluble form. To test this model, we use an assay based on Xenopus animal cap explants in which Spi activation of DER is Rhomboid and Star dependent. We show that Spi is on the cell surface but is kept in an inactive state by its cytoplasmic and transmembrane domains; Rhomboid and Star relieve this inhibition, allowing Spi to signal. We show further that Spi is likely to be cleaved within its transmembrane domain. However, a mutant form of mSpi that is not cleaved still signals to DER in a Rhomboid and Star-dependent manner. These results suggest strongly that Rhomboid and Star act primarily to present an active form of Spi to DER, leading secondarily to the processing of Spi into a secreted form.
Up-regulation of NK Cell Activating Receptors Following Allogeneic Hematopoietic Stem Cell Transplantation under a Lymphodepleting Reduced Intensity Regimen is Associated with Elevated IL-15 Levels (2008)

Because natural killer (NK) cells can be potent anti-tumor effectors after allogeneic stem cell transplantation, we investigated NK reconstitution and receptor expression in patients undergoing allogeneic hematopoietic stem cell transplantation, focusing on the activating receptors that trigger anti-tumor responses. We determined that NK levels in the peri-transplant period were inversely proportional to the dramatic rise and fall in plasma levels of the NK homeostatic cytokine IL-15, which increased more than 50-fold from pretreatment to the day of transplant during the lymphoreductive preparative regimen. Furthermore, in NK cells cultured with IL-15, we observed an up-regulation of the activating receptors NKG2D, NKp30, and NKp46, associated with an increase in anti-tumor lytic activity. Similarly, the expression of these activating receptors increased significantly during the early post-transplant period, concurrent with a rapid increase in total NK cells and a shift toward increased expression of CD56. These data suggest that the cytokine milieu of transplants, in particular elevated levels of IL-15, may contribute to anti-tumor efficacy post-transplant by enhancing the recovery of NK subsets and modulating expression of activating receptors.
PLATINUM IMPLANT IN GLAUCOMA SURGERY (1951)

THIS PAPER describes the clinical and pathological observations on the use of intraocular platinum implants in rabbit eyes and reports on the use of a platinum wire seton in two human eyes with glaucoma. The idea of using a foreign body as a method of making a drainage tract for the flow of aqueous in glaucoma is not new. Troncoso<sup>1</sup>in 1940, in an extensive article, reviewed the literature on intraocular implants. He reported his results on the implantation of magnesium experimentally in rabbit eyes and on the use of magnesium implants in 12 glaucomatous human eyes. The metal was inserted between the sclera and the ciliary body in the cyclodialysis operation with the object of preventing reattachment of the ciliary body to the sclera. His conclusions were as follows: There was at first a mild reaction to the foreign body, with numerous bubbles of gas appearing in the
Modeling of Bulk Evaporation and Condensation (1996)

This report describes the modeling and mathematical formulation of the bulk evaporation and condensation involved in liquid-vapor phase change processes. An internal energy formulation, for these phase change processes that occur under the constraint of constant volume, was studied. Compared to the enthalpy formulation, the internal energy formulation has a more concise and compact form. The velocity and time scales of the interface movement were obtained through scaling analysis and verified by performing detailed numerical experiments. The convection effect induced by the density change was analyzed and found to be negligible compared to the conduction effect. Two iterative methods for updating the value of the vapor phase fraction, the energy based (E-based) and temperature based (T-based) methods, were investigated. Numerical experiments revealed that for the evaporation and condensation problems the E-based method is superior to the T-based method in terms of computational efficiency. The internal energy formulation and the E-based method were used to compute the bulk evaporation and condensation processes under different conditions. The evolution of the phase change processes was investigated. This work provided a basis for the modeling of thermal performance of multi-phase nuclear fuel elements under variable gravity conditions, in which the buoyancy convection due to gravity effects and internal heating are involved.
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation (2022)

Genetically modified kidney xenografts from pigs remained viable and functioning in brain-dead human recipients for 54 hours, without signs of hyperacute rejection. (Funded by Lung Biotechnology.).
Synthesis of Racemic Ribose from d-Glucose (1999)

Racemic ribose is a valuable starting material for investigations of the origins of biomolecular homochirality. It can be synthesized in seven steps starting from d-glucose.
Changes in negative and positive EEG shifts during slow cortical potential training in children with attention-deficit/hyperactivity disorder (2014)

We examined the effects of self-regulation of slow cortical potentials (SCP) in nine children with attention-deficit/hyperactivity disorder (ADHD) by focusing on the changes in electroencephalographic (EEG) shifts during SCP sessions. In SCP training, individuals learn to increase and decrease their cortical excitabilities (enhancement of negative and positive cortical shifts). To examine the efficiency of SCP training, we conducted an attention task and measured contingent negative variation, which relates to the attention maintenance ability. Moreover, to assess training effects at the behavioral level, the Japanese ADHD rating scale (SNAP-J) was completed by the parents. In SCP training, we analyzed changes in EEG shifts during 16 training sessions by calculating the peak amplitudes of positive and negative shifts. The results of EEG data showed that peak amplitudes increased in sessions 11 and 12 for negative shifts and in sessions 9 and 13 for positive shifts. Moreover, we found an enhancement of contingent negative variation amplitude in the attention task before and after training, suggesting that the ability of these children to maintain attention could be modified by SCP training. However, significant behavioral improvements were not observed on the Japanese ADHD rating scale. It has been proposed that the number of additional training sessions may affect both physiological and behavioral improvements. Our present results, however, suggest the possibility that even low numbers of training sessions, such as 16, can bring about physiological improvement, whereas greater numbers of training sessions may be needed to have an influence on behavioral changes.