gebhart/patrepeval huggingface dataset:
Possible Effects of Cochlear Hydrops and Related Phenomena (2001)

There is some question in the literature concerning the effects of hydrops on otoacoustic emissions (OAEs), and the usefulness of OAE measurement in the differential diagnosis of Ménière's disease and related disorders remains unclear. It is reasonable to expect different effects in various cochlear pathologies, especially between those causing primarily low-frequency (LF) versus high-frequency (HF) hearing losses, as typically associated with putative fluid mechanical lesions versus hair cell damage, respectively. We report observations on distortion product OAEs in patients with LF and combinations of LF and HF losses and discuss problems of relating DPOAE output to the LF ``hydrops'' audiogram. We then describe effects specifically of intralabyrinthine pressure on OAEs, a possible factor in hydrops. It is clear from results in the literature and in our own clinics and laboratories that OAEs are sensitive to intralabyrinthine static pressure. These measures may or may not accurately reflect the hydrops hearing loss. The results are thus complex, doubtlessly reflecting the complexity and dynamics of diseases such as Ménière's. On the other hand, the effect of intralabyrinthine pressure per se is predictable and can be demonstrated to be rather predictable in humans.
Testing object-oriented industrial software without precise oracles or results (2007)

TACCLE tests an automated assembly system in which the expected outcomes cannot be precisely defined and the actual results cannot be directly observed.
An integrated genomic analysis of papillary renal cell carcinoma type 1 uncovers the role of focal adhesion and extracellular matrix pathways (2015)

Papillary renal cell carcinoma (pRCC) is the second most common RCC subtype and can be further classified as type 1 (pRCC1) or 2 (pRCC2). There is currently minimal understanding of pRCC1 pathogenesis, and treatment decisions are mostly empirical. The aim of this study was to identify biological pathways that are involved in pRCC1 pathogenesis using an integrated genomic approach. By microarray analysis, we identified a number of significantly dysregulated genes and microRNAs (miRNAs) that were unique to pRCC1. Integrated bioinformatics analyses showed enrichment of the focal adhesion and extracellular matrix (ECM) pathways. We experimentally validated that many members of these pathways are dysregulated in pRCC1. We identified and experimentally validated the downregulation of miR-199a-3p in pRCC1. Using cell line models, we showed that miR-199a-3p plays an important role in pRCC1 pathogenesis. Gain of function experiments showed that miR-199a-3p overexpression significantly decreased cell proliferation (p = 0.013). We also provide evidence that miR-199a-3p regulates the expression of genes linked to the focal adhesion and ECM pathways, such as caveolin 2 (CAV2), integrin beta 8 (ITGB8), MET proto-oncogene and mammalian target of rapamycin (MTOR). Using a luciferase reporter assay, we further provide evidence that miR-199a-3p overexpression decreases the expression of MET and MTOR. Using an integrated gene/miRNA approach, we provide evidence linking miRNAs to the focal adhesion and ECM pathways in pRCC1 pathogenesis. This novel information can contribute to the development of effective targeted therapies for pRCC1, for which there is none currently available in the clinic.
On-chip reduced-code static linearity test of $V_{cm}$ -based switching SAR ADCs using an incremental analog-to-digital converter (2020)

This paper describes a BIST technique for the static linearity test of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$V_{cm}$</tex> -based successive-approximation analog-to-digital converters (SAR ADCs). We discuss the application of reduced-code techniques for the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$V_{cm}$</tex> -based SAR ADC topology and present a practical on-chip implementation based on an embedded incremental ADC. Simulation results are provided for validating the feasibility and performance of the proposed on-chip reduced-code static linearity test.
Animating Athletic Motion Planning By Example (2000)

Character animation is usually reserved for highly skilled animators and computer programmers because few of the available tools allow the novice or casual user to create compelling animated content. In this paper, we explore a partial solution to this problem which lets the user coach animated characters by sketching their trajectories on the ground plane. The details of the motion are then computed with simulation. We create memory-based control functions for the high-level behaviors from examples supplied by the user and from real-world data of the behavior. The control function for the desired behavior is implemented through a lookup table using a K-nearest neighbor approximation algorithm. To demonstrate this approach, we present a system for defining the behaviors of defensive characters playing American football. The characters are implemented using either point-masses or dynamically simulated biped robots. We evaluate the quality of the coached behaviors by comparing the resulting trajectories to data from human players. We also assess the influence of the user's coaching examples by demonstrating that a user can construct a particular style of play.
Bipolar pulse technique for fast conductance measurements (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBipolar pulse technique for fast conductance measurementsDonald Edwin. Johnson and C. G. EnkeCite this: Anal. Chem. 1970, 42, 3, 329–335Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ac60285a015https://doi.org/10.1021/ac60285a015research-articleACS PublicationsRequest reuse permissionsArticle Views332Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Frequency‐Agile Antennas for a Software‐Defined and Cognitive Radio (2007)

This chapter contains sections titled: Introduction Two-Port Representation of an Antenna Automatic Antenna Tuning Unit (AATU) AATU Prototype and Test Setup Summary References
Towards design support for provenance awareness (2013)

As the complexity of online services increases, there is a corresponding need for service-oriented systems to provide support for answering questions about how they have processed and produced data. This need is particularly evident in compositions of services, where audits of each individual service's use do not provide a connected picture of the composition's processing history. The provenance awareness of a system is its ability to answer questions about the history of its processing, through recording provenance data during execution. As the size and usage of a system increases, so can the size of the provenance data recorded, leading to increased demands on storage and decreased performance of the service. However, the exact impact of provenance recording depends on what details of the service execution are being documented. Our goal is to make provenance awareness accessible as an explicit non-functional property (NFP) in composite service specifications, as is common for performance or reliability properties. This would enable composite service designers to analyse the properties of their services to see whether they meet users' requirements based on the provenance questions they could ask about the service's outputs and the dependent performance, storage and other properties. We present a preliminary approach towards this end, focusing on the step of categorising potential provenance questions according to their effect on other NFPs, so that the provenance awareness of a service can be specified as the categories of questions it can answer.
Soft and Hard Adhesion (2005)

ABSTRACT The force needed to pull a cylindrical stud from a soft elastomeric film depends on their elastic and geometric properties. For a rigid stud and a thick elastomeric film, the pull-off stress (σ) depends on the elastic modulus (E) of the film and the radius (a) of the stud as σ ∼ (E/a)1/2 (soft adhesion). However, when the film is very thin, the pull-off stress is significantly higher than the case with thick films, and its value depends on the elastic modulus and the thickness (h) of the film as σ ∼ (E/h)1/2 (hard adhesion). Here, we study the pull-off behavior of a soft cylindrical stud, one flat end of which is coated with a high modulus thin baseplate. As the flexural rigidity of this baseplate is varied, we observe the transition between the two types of adhesion. We present a simple physical interpretation of the problem, which could be of value in understanding various biofouling and adhesive situations.
Transitioning BioVLab cloud workbench to a science gateway (2011)

BioVLab gateway is built upon Open Gateway Computing Environments and is currently used as reconfigurable cloud computing workbench. In this talk, we will discuss the new directions towards a TeraGrid Science Gateway and experiences and technical challenges in migrating a Cloud workbench Grid based science gateway.
Poly(borosilazane) Precursors to Ceramic Nanocomposites (1999)

Single-component polymeric precursors to SiC/Si3N4/C/BN and Si3N4/BN ceramic nanocomposites were synthesized via hydroboration and dehydrocoupling of vinyl-containing cyclotrisilazanes. The polymer-to-ceramic conversion process was investigated by 13C, 29Si, and 11B solid-state magic-angle spinning (MAS) NMR spectroscopy, FTIR spectroscopy, thermal analysis, elemental analysis, X-ray diffraction (XRD), and transmission electron microscopy. The yields, processibility, and resulting microstructure of the ceramics were dependent on the starting Si/B ratio in the polymers and the atmosphere used for pyrolysis. Thermal conversion of the polymers from 200 to 600 °C involved loss of vinyl functionality, an increase in the amount of B−N environments, and possibly some degradation of the silazane ring structure. Conversion of the polymeric environment to that of mixed-phase ceramic was complete between 600 and 1000 °C; XRD, however, showed the products to be amorphous even after heating to 1600 °C. Heating the N2 pyrolyzed products to 1800 °C resulted in β-Si3N4, β-SiC, and t-BN peaks in the XRD powder patterns, while α-Si3N4 and β-Si3N4 peaks were observed for the NH3 pyrolyzed products.
Wavelet‐based index of magnetic storm activity (2006)

A wavelet‐based method of computing an index of storm activity is put forward. The new index can be computed automatically using statistical procedures and does not require selecting quiet days and removing the secular component by polynomial fitting. This 1‐min index is designed to facilitate the study of the fine structure of geomagnetic storm events and requires only the most recent magnetogram records, e.g., the 2 months including the storm event of interest. It can thus be computed over a moving window as soon as new magnetogram records become available. Averaged over 1‐hour periods, it is practically indistinguishable from the standard Dst index.
Improvement in treatment satisfaction after switching from liraglutide to dulaglutide in patients with type 2 diabetes: A randomized controlled trial (2018)

Weekly administration of dulaglutide was superior to liraglutide with regard to treatment satisfaction in patients with type 2 diabetes, in the absence of any negative effect on glycemic control.
Tetranuclear Bimetallic Complexes of Ruthenium, Osmium, Rhodium, and Iridium. Synthesis, Absorption Spectra, Luminescence, and Electrochemical Properties (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetranuclear Bimetallic Complexes of Ruthenium, Osmium, Rhodium, and Iridium. Synthesis, Absorption Spectra, Luminescence, and Electrochemical PropertiesScolastica Serroni, Alberto Juris, Sebastiano Campagna, Margherita Venturi, Gianfranco Denti, and Vincenzo BalzaniCite this: J. Am. Chem. Soc. 1994, 116, 20, 9086–9091Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00099a026https://doi.org/10.1021/ja00099a026research-articleACS PublicationsRequest reuse permissionsArticle Views962Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PMRD: plant microRNA database (2009)

MicroRNAs (miRNA) are approximately 21 nucleotide-long non-coding small RNAs, which function as post-transcriptional regulators in eukaryotes. miRNAs play essential roles in regulating plant growth and development. In recent years, research into the mechanism and consequences of miRNA action has made great progress. With whole genome sequence available in such plants as Arabidopsis thaliana, Oryza sativa, Populus trichocarpa, Glycine max, etc., it is desirable to develop a plant miRNA database through the integration of large amounts of information about publicly deposited miRNA data. The plant miRNA database (PMRD) integrates available plant miRNA data deposited in public databases, gleaned from the recent literature, and data generated in-house. This database contains sequence information, secondary structure, target genes, expression profiles and a genome browser. In total, there are 8433 miRNAs collected from 121 plant species in PMRD, including model plants and major crops such as Arabidopsis, rice, wheat, soybean, maize, sorghum, barley, etc. For Arabidopsis, rice, poplar, soybean, cotton, medicago and maize, we included the possible target genes for each miRNA with a predicted interaction site in the database. Furthermore, we provided miRNA expression profiles in the PMRD, including our local rice oxidative stress related microarray data (LC Sciences miRPlants_10.1) and the recently published microarray data for poplar, Arabidopsis, tomato, maize and rice. The PMRD database was constructed by open source technology utilizing a user-friendly web interface, and multiple search tools. The PMRD is freely available at http://bioinformatics.cau.edu.cn/PMRD. We expect PMRD to be a useful tool for scientists in the miRNA field in order to study the function of miRNAs and their target genes, especially in model plants and major crops.
Intermedia-based video adaptation system: Design and implementation (2012)

Video adaptation is a promising technique to bridge the gap between network status, device capabilities, and user preferences in pervasive media applications. However, conventional adaptation frameworks based on either transcoding or multiple pre-transcoding are not able to accommodate large numbers of users with diversified applications. This paper introduces an intermediate video description called “Intermedia”, which consists of multiple level video signal components, such as texture, motion, and rate control information, as well as some semantic features, such as structural characteristics and Region Of Interest (ROI) information. It is generated off-line and stored in the video server or media gateway. Intermedia is then used to design a novel video adaptation system. The proposed adaptation system quickly and easily generates the required bit stream from Intermedia with very low complexity to fulfill a series of specific adaptation requirements, e.g., bitrate conversion, temporal/spatial resolution reduction, video summarization, ROI browsing, and some multi-level adaptations involving both signal level and semantic level adaptation. The satisfactory performance of such a system demonstrates the effectiveness and efficiency of the proposed video adaptation framework.
Novel mutations of theRPGR gene in RP3 families (2000)

X-linked retinitis pigmentosa is a severe retinal degeneration characterized by night blindness and visual field constriction, leading to complete blindness within the third decade of life. Mutations in the RPGR gene (retinitis pigmentosa GTPase regulator), located on Xp21.1 in the RP3 region, have been associated with an RP phenotype. Further to our previous mutation screening of RPGR in families segregating with the RP3 locus, we have expanded this study to include other 8 RP3 pedigrees. Here we report the results of this expanded study and the identification of five mutations in RPGR, four of which are novel (IVS6+5 G>A, 950-951delAA, 963 T>C, EX8del) and one of which occurs in the donor splice site of intron 1 (IVS1+1 G>A). These findings bring the proportion of "RP3 genotypes" with a mutation in this gene to 27% (10/37). Hum Mutat 15:386, 2000.
Speech Source Separation in Convolutive Environments Using Space-Time-Frequency Analysis (2006)

We propose a new method for speech source separation that is based on directionally-disjoint estimation of the transfer functions between microphones and sources at different frequencies and at multiple times. The spatial transfer functions are estimated from eigenvectors of the microphones' correlation matrix. Smoothing and association of transfer function parameters across different frequencies are performed by simultaneous extended Kalman filtering of the amplitude and phase estimates. This approach allows transfer function estimation even if the number of sources is greater than the number of microphones, and it can operate for both wideband and narrowband sources. The performance of the proposed method was studied via simulations and the results show good performance.
Status of High-Temperature Laminating Resins and Adhesives (1980)

The quest for high temperature polymers for use as functional resins (e.g., coatings and sealants) and structural resins (e.g., adhesives, composite matrices and foams) began in the mid-1950's. Early work on high temperature polymers concentrated primarily on thermal stability and paid little or no attention to cost, processability, performance or actual use temperature. As work progressed, it was quickly recognized that a successful polymer must exhibit a favorable combination of price, processability and performance and also that thermal stability differed from dimensional stability or heat resistance. Work on most of the more exotic and costly polymers was soon discontinued as a result of this realism and the more current emphasis has generally been restricted to the development of materials for specific applications. In fact, this review will be confined to those high temperature polymers currently being developed as adhesives and composite matrices. The term "high temperature" in this context refers
Synthesis of a membrane-insertable, sodium cation conducting channel: kinetic analysis by dynamic sodium-23 NMR (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a membrane-insertable, sodium cation conducting channel: kinetic analysis by dynamic sodium-23 NMRAkio Nakano, Qingshan Xie, Jesus V. Mallen, Luis Echegoyen, and George W. GokelCite this: J. Am. Chem. Soc. 1990, 112, 3, 1287–1289Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00159a083https://doi.org/10.1021/ja00159a083research-articleACS PublicationsRequest reuse permissionsArticle Views453Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Year in Review—2019 (2019)

Kathleen Burke, PhD, RN-BC, CENP, FAAN, is Corporate Director, Nursing Professional Development and Innovation, and Co Director, Continuing Interprofessional Education, University of Pennsylvania Health System; Advanced Senior Lecturer, School of Nursing, and Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania; and Editor-in-Chief, Journal for Nurses in Professional Development. The author declares no conflicts of interest.