gebhart/patrepeval huggingface dataset:
Data from Genome-Protective Topoisomerase 2a-Dependent G<sub>2</sub> Arrest Requires p53 in hTERT-Positive Cancer Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Topoisomerase 2a (Topo2a)-dependent G&lt;sub&gt;2&lt;/sub&gt; arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms associated with this G&lt;sub&gt;2&lt;/sub&gt; arrest by determining that p53–p21 signaling is essential for efficient arrest in cell lines, in patient-derived cells, and in colorectal cancer organoids. Regulation of this p53 axis required the SMC5/6 complex, which is distinct from the p53 pathways observed in the DNA damage response. Topo2a inhibition specifically during S phase did not trigger G&lt;sub&gt;2&lt;/sub&gt; arrest despite affecting completion of DNA replication. Moreover, in cancer cells reliant upon the alternative lengthening of telomeres (ALT) mechanism, a distinct form of Topo2a-dependent, p53-independent G&lt;sub&gt;2&lt;/sub&gt; arrest was found to be mediated by BLM and Chk1. Importantly, the previously described PKCε-dependent mitotic failsafe was engaged in hTERT-positive cells when Topo2a-dependent G&lt;sub&gt;2&lt;/sub&gt; arrest was dysfunctional and where p53 was absent, but not in cells dependent on the ALT mechanism. In PKCε knockout mice, p53 deletion elicited tumors were less aggressive than in PKCε-replete animals and exhibited a distinct pattern of chromosomal rearrangements. This evidence suggests the potential of exploiting synthetic lethality in arrest-defective hTERT-positive tumors through PKCε-directed therapeutic intervention.&lt;/p&gt;Significance:&lt;p&gt;The identification of a requirement for p53 in stringent Topo2a-dependent G&lt;sub&gt;2&lt;/sub&gt; arrest and engagement of PKCε failsafe pathways in arrest-defective hTERT-positive cells provides a therapeutic opportunity to induce selective synthetic lethality.&lt;/p&gt;&lt;/div&gt;
Describing and Measuring the Chemical Signatures of Life (2000)

Here we discuss an approach to remotely detecting extraterrestrial life forms on other planets or their moons by detection of specific types of organic molecules. The life entities to be detected would be presently active life forms, or those that are only recently dormant. The only place beside Earth's moon where humans have actually examined surface soils for the presence of organic molecules is Mars. This was accomplished using mass-spectrometry during the Viking mission, and results were negative. The lack of organic moieties, if they ever were present, probably resulted form their destruction over geologic time frames by the extraordinarily reactive surface soils found there. Thus, on Mars, detection of organic signatures of life probably would be possible only in subsurface soils, or perhaps in polar regions.
Modeling the stress dependence of Barkhausen phenomena for stress axis linear and noncollinear with applied magnetic field (abstract) (1996)

The almost linear dependence of the maximum Barkhausen noise signal amplitude on stress has made it a tool for nondestructive evaluation of residual stress. Recently, a model has been developed to account for the stress dependence of the Barkhausen noise signal. The model uses the development of Alessandro et al. who use coupled Langevin equations to derive an expression for the Barkhausen noise power spectrum. The model joins this expression to the magnetomechanical hysteresis model of Sablik et al., obtaining both a hysteretic and stress-dependent result for the magnetic-field-dependent Barkhausen noise envelope and obtaining specifically the almost linear stress dependence of the Barkhausen noise maximum experimentally. In this paper, we extend the model to derive the angular dependence observed by Kwun of the Barkhausen noise amplitude when stress axis is taken at different angles relative to magnetic field. We also apply the model to the experimental observation that in XC10 French steel, there is an apparent almost linear correlation with stress of hysteresis loss and of the integral of the Barkhausen noise signal over applied field H. Further, the two quantities, Barkhausen noise integral and hysteresis loss, are linearly correlated with each other. The model shows how that behavior is to be expected for the measured steel because of its sharply rising hysteresis curve.
High power 1178 nm single-frequency MOPA based on OP-SDL and PBGF (2013)

We report a high power single-frequency 1178 nm laser combining an optically-pumped semiconductor disk laser and an Yb-doped photonic bandgap fiber amplifier. An output power of 31 W with <;200 kHz linewidth without SBS was demonstrated.
Web-based tutoring from a knowledge library (2002)

With modern technology, rapid change characterizes complex dynamic systems, including the practitioners' role and required knowledge. Training in safety-critical domains must occur in a timely manner and ensure that practitioners understand changing systems and procedures. Web-based training provides an excellent opportunity to address these issues because distribution of training can be timely, easily accessed and cost-efficient. Few sophisticated training systems exist for practitioners of complex dynamic systems. GT-ITACS (Georgia Tech Intelligent Architecture for Complex Systems) was designed and implemented as an intelligent tutoring system (ITS) "shell" to support several ongoing Georgia Tech ITS research efforts. Access to domain-specific education and training from a Web-based library may meet the needs of training programs by allowing easy access to ongoing education and training material.
Kinetics of interfacial charges in hybrid GaAs/oligothiophene semiconducting heterojunctions (2007)

The authors report on pump-probe measurements in a hybrid heterostructure consisting of a modified oligothiophene layer deposited over a GaAs substrate. Upon photoexcitation of the bilayer with 100fs, a new photoinduced absorption band (PA2) appeared being attributed to oligothiophene cations arising from exciton diffusion and dissociation at the hybrid inorganic/organic interface. An exciton diffusion length in the organic layer of approximately 3.4 nm was estimated.
Dairy‐derived bioactive fatty acids improve pancreatic ß‐cell function (2015)

Recent studies suggest that diets rich in dairy products protect against type 2 diabetes. The principal constituents responsible are thought to be bioactive lipids, in particular trans ‐palmitoleic acid ( trans ‐9 16:1; TPA), although the nature of this protection is unknown. We have recently identified another milk‐derived fatty acid (FA) that may be, in part, responsible for these effects: 15‐methyl‐hexadecanoic acid, a branched‐chain FA (iso 17:0; MHA). Using the INS‐1 ß‐cell line to examine chronic effects of hyperglycemia, we characterized these two FAs with respect to altering levels of the key ß‐cell transcription factor, Pdx1. INS‐1 cells subjected to chronic high glucose (20 mM) for 24‐72 h exhibited ~50% reduced Pdx1 levels. At 24 h, neither MHA, TPA, or MHA+TPA (each at 10 μm) affected Pdx1; however, under basal (5.5 mM) glucose conditions, both TPA and MHA+TPA increased Pdx1. By 48 h, MHA supplementation markedly increased Pdx1 levels in high glucose cultures (2.6‐fold). Accordingly, 72 h cultures with 20 mM glucose + MHA maintained modestly elevated Pdx1 levels (1.25‐fold). We have previously shown that ß‐cell PPARγ regulates pdx1 expression. Positive MHA‐specific effects on Pdx1 protein levels under hyperglycemic conditions are transcriptionally conferred as demonstrated by a 2‐fold enhancement of activity in a pdx1 reporter assay. Similarly, both MHA and TPA elicited ~2‐fold increases in ppar γ activity. Collectively, these data demonstrate distinct and potentially complementary bioactivities of dairy‐derived MHA and TPA. We postulate that a key target of these bioactive FAs responsible for modulating diabetes risk is the pancreatic ß‐cell.
Synthesis and Characterization of Bioactive Sodium Titanate Nanotube by Alkali Hydrothermal Treatment (2007)

In the present work, surface treatment of surgical implant Titanium alloy with micro bioactive nanotube was experimented. Surface treatment of Ti-6Al-4V bio-implant carried out by giving alkali hydrothermal and heat treatment. The specimens were treated in 1M NaOH at 100, 150, 200°C for different holding time of 2 hr, 4 hr, 6hr, 12 hr, 24hr &amp; 48 hr. The hydrogel layer generated during the alkali treatment was crystallized to sodium titanate (Na2Ti6O13) and resulted into the formation of nano sized tubes on heat treatment. X-ray Diffractrometry (XRD), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) revealed the different phases and surface morphology of these nanorods. The biocompatibility test done using Simulate Body Fluid (SBF) showed that the Hydroxyapatite (HAp) was well formed at the sodium titanate nanotube layer generated on the Ti-6Al-4V specimen. The best condition for this increase in surface biocompatibility was optimized to 6 hours hydrothermal treatment under 200°C using 1 M NaOH followed by 1 hour heat treatment at 600°C.
Critical dynamics of spontaneous symmetry breaking in a homogeneous Bose gas (2015)

Kibble-Zurek theory models the dynamics of spontaneous symmetry breaking, which plays an important role in a wide variety of physical contexts, ranging from cosmology to superconductors. We explored these dynamics in a homogeneous system by thermally quenching an atomic gas with short-range interactions through the Bose-Einstein phase transition. Using homodyne matter-wave interferometry to measure first-order correlation functions, we verified the central quantitative prediction of the Kibble-Zurek theory, namely the homogeneous-system power-law scaling of the coherence length with the quench rate. Moreover, we directly confirmed its underlying hypothesis, the freezing of the correlation length near the transition. Our measurements agree with a beyond-mean-field theory and support the expectation that the dynamical critical exponent for this universality class is z = 3/2.
Network coding, multi-packet reception, and feedback : design tools for wireless broadcast networks (2011)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.
Reactivity of Wheat Gluten Protein during Mechanical Mixing: Radical and Nucleophilic Reactions for the Addition of Molecules on Sulfur (2007)

Mechanical properties of gluten-based biomaterials, such as break stress, were known to be influenced by temperature and shear stresses applied during processing. It is well documented in literature that these processing parameters promoted wheat gluten protein aggregation. Exchange between disulfide bonds and thiol groups oxidation are the postulated mechanisms that lead to gluten protein solubility loss in sodium dodecyl sulfate buffers. Both nucleophilic and radical reactions were postulated to act during gluten aggregation. To graft molecules on gluten, a study was carried out to explore the reactivity of its thiol and disulfide groups during thermomechanical mixing. A range of reactants able to react via radical or nucleophilic pathways with thiol groups were synthesized. Reactivity between gluten and functions was quantified by gluten solubility measurements. This investigation and literature observations allowed proposal of a general gluten aggregation mechanism during mixing.
Layered Tb‐Doped Yttrium Carboxyphosphonate Nanocrystals as Efficient Filler for PEDOT:PSS Composite Films (2017)

Abstract A layered yttrium phosphonate based on N ‐(phosphonomethyl)glycine (H 3 L) and of formula Y(PO 3 CH 2 NHCH 2 COOH)(HPO 3 CH 2 NHCH 2 COOH) was synthesized in mild hydrothermal conditions. Its crystal structure was first determined by single‐crystal X‐ray diffraction. Then, the synthetic parameters were changed in order to reduce the particle size of the compound. The use of microwave (MW) irradiation during the synthesis allowed a) to obtain the compound in form of nanoparticles (NP) in the 50–300 nm range dispersed in water, b) to strongly reduce the reaction time by a factor 150, and c) to successfully introduce into the structure small amounts of a luminescent ion like terbium(III) as an isomorphic substituent of yttrium(III). The obtained NP were used to prepare composite materials by dispersing them in poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The resulting optical, photophysical, morphological and electrical properties of modified and pristine PEDOT:PSS films were investigated and compared, in order to test the potential use of Y(H 2 L)(HL) NP as luminescent downshifting materials in optoelectronic devices.
Bayesian multiuser detection based on a network of NLMS filters (2006)

The Network of Kalman Filters structure was proposed, re-cently, to perform an optimal Bayesian symbol-by-symbol estimation in the multiuser detection context. By approxi-mating the prediction error covariance matrix on each branch by a constant diagonal one, we show in this paper that the NKF structure can be expressed into a particular Network of normalized LMS filters exhibiting less computational com-plexity. The choice of the value of the step-size is also dis-cussed. In order to overcome its heuristic choice, we, here, propose a new adaptive step size based on the second order moment of the estimated symbols. The form of the step-size still contains an information on the a priori state esti-mation. The performance of the resulted receiver structure is evaluated by means of computer simulations for very high asynchronous system load, in multipath fading channel, and compared to MAP, NKF, MMSE and Rake receivers. 1.
ac Susceptibility Transition in Type-II Superconductors and Surface Critical Currents (1966)

The ac susceptibility transition below ${H}_{c3}$ has been investigated as a function of ac field amplitude, in cylindrical samples of Pb-Bi alloys ($l&lt;~\ensuremath{\kappa}&lt;~5$). Converting the ac fields to critical surface currents ${J}_{c}$ permits comparison with the values calculated by Abrikosov and Park. The present results agree with those of Swartz and Hart, and of Rollins and Silcox. Although above ${H}_{c2}$ the qualitative behavior is similar to the theoretical calculations, the magnitudes are found to be lower. At ${H}_{c2}$ a sharp break is found in ${J}_{c}$, as reported previously. $\frac{{J}_{c}\ensuremath{\kappa}}{{H}_{c}}$ is found to be independent of $\ensuremath{\kappa}$ within experimental error. Surface roughness and slight sample misalignment could have lowered the observed ${J}_{c}$.
Cell surface glycoprotein associated with human lung tumors that is similar to but distinct from the epidermal growth factor receptor. (1989)

A cell surface glycoprotein (gp160) present on the surface of non-small cell human lung tumors is characterized and compared with the epidermal growth factor receptor (EGFR). The epitope on gp160 recognized by monoclonal antibody 5E8 is shown to be part of the protein moiety of the molecule and is found to be relatively stable. The epitope is stable over a wide pH range and after treatment with urea as well as most ionic and non-ionic detergents. We have observed that gp160 is similar in several respects to the EGFR. However, despite the similarities, several independent lines of experimental evidence presented here suggest that gp160 and the EGFR are distinct molecules. The first evidence suggesting that these two molecules are different is that the EGFR, but not gp160, is constitutively detectable in the A431 cell tissue culture supernatant, and that a pulse of these cells with epidermal growth factor (under conditions which permit the internalization of the receptor-ligand complexes) significantly reduces the expression of the EGFR without noticeably affecting the level of gp160 on the cell surface. Two very different immunofluorescent patterns marking the position of gp160 and EGFR are observed using monoclonal antibodies specific for each molecule. Using an enzyme-linked immunosorbent assay, it was determined that these same monoclonal antibodies do not cross-inhibit one another, and it was established that gp160, but not EGFR, was retained on an affinity column containing anti-gp160 antibodies immobilized to the solid matrix. An additional finding that supports the notion that gp160 and the EGFR are distinct molecules is that one human lung tumor cell line (Calu-3) has been identified which expresses gp160 but not the EGFR on its surface. These results indicate that there are characteristics which distinguish gp160 from the EFGR, and we establish here that these distinguishing features reflect differences at the protein moiety and not simply differential glycosylation. We conclude from these studies that we have identified and characterized a cell surface molecule that resembles in several respects the epidermal growth factor receptor. This cell surface molecule represents a potentially useful target for the immunotherapy and diagnosis of human non-small cell lung cancer.
Effect of bilateral adrenalectomy on metabolism of calcium, magnesium and phosphorus in black bengal goat (2007)

Calcium, Magnesium and Phosphorus level were studied in bilateral adrenalectomized (BADX) goat to see the role of adrenal hormones in metabolism of those said minerals. Initially Ca level reduced significantly (P<0.01) and thereafter approaching towards normal value but overall decreasing trend was found. Magnesium had the similar trend like Ca but later stages increased in erratic fashion. Phosphorus initially decreased (P<0.01) but decreasing trend though erratic way was noticed at later stages.
Association of kidney function and albuminuria with cardiovascular mortality in older vs younger individuals: The HUNT II Study. (2007)

Reduced kidney function and microalbuminuria are risk factors for cardiovascular death, independent of each other and traditional risk factors. The combined variable improved cardiovascular risk stratification at all age levels, but particularly in elderly persons where the predictive power of traditional risk factors is attenuated.
Techniques for mounting an ultrasonic temperature device Final report (1966)

Transducer mounting technique for applying ultrasonic method of temperature measurement to rocket thrust chambers
Angiotensin-II Receptor Subtypes in Median Eminence and Basal Forebrain Areas Involved in Regulation of Pituitary Function (1991)

We used quantitative autoradiography to characterize angiotensin-II (ANG-II) receptor subtypes in areas of the rat basal forebrain involved in pituitary control. ANG binding was totally displaced by the selective AT1 receptor subtype antagonist DuP 753 and was inhibited by dithiothreitol in median eminence, infundibular stem, paraventricular nucleus, subfornical organ, median preoptic nucleus, anterior pituitary, and the forebrain ANG-II receptor band, which extends from the subfornical organ to the vascular organ of the lamina terminalis, including the lamina terminalis and a continuous band of receptors reaching the paraventricular nucleus. In these areas, binding was not affected by the selective AT2 competitors PD 123177 or CGP 42112 A, indicating the presence of AT1 and the absence of AT2 receptors. AT1 binding was higher in the external layer and lateral parts of the median eminence. Conversely, ANG binding in the dura mater encapsulating the pituitary, in the vessels adjacent to this part of the dura mater, presumably branches of the hypophyseal arteries, and in anterior cerebral arteries was displaced by PD 123177 and CGP 42112 A, and was unaffected by dithiothreitol or DuP 753, indicating the presence of AT2 receptors in these structures. Our results implicate AT1 receptors in the central neural regulation of pituitary function. AT2 receptors may play a role in the regulation of blood flow to the basal forebrain and the pituitary gland.
Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans (2015)

The data elucidate the pathways of metabolism of dietary hesperidin in vivo and will facilitate better design of mechanistic studies both in vivo and in vitro.
Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study (2019)

Long term use of systemic hormone therapy might be accompanied with an overall increased risk of Alzheimer's disease, which is not related to the type of progestogen or the age at initiation of systemic hormone therapy. By contrast, use of vaginal estradiol shows no such risk. Even though the absolute risk increase for Alzheimer's disease is small, our data should be implemented into information for present and future users of hormone therapy.
ChemInform Abstract: Microwave‐Assisted Diels—Alder Synthesis. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Macromol. Mater. Eng. 1/2012 (2012)

Front Cover: Unlike the normal pristine MMT particles, which are compact and plane-shaped, these spray-dried pristine MMT particles display extraordinary flower-shaped morphologies. This indicates that the rapid evaporation process brought about by the spray-drying method achieves structures made of randomly arranged MMT layers in the granule. Further details can be found in the article by M. Lu, Y. Wang, Y. Wu, Y. Quan, X. Wu, L. Zhang,* and B. Guo on page 20.
ChemInform Abstract: HOMOGENEOUS CATALYSIS BY TRANSITION METAL COMPLEXES. SELECTIVE OXIDATION OF CYCLOHEXENE BY MIXED‐CATALYSTS CONTAINING RHODIUM(II) COMPLEXES (1979)

Abstract Die Oxidation von Cyclohexen (I) mit Sauerstoff in Gegenwart von Gemischen aus Rhodiu (lhcarboxylaten (III) und Epoxidations‐Katalysatoren (IV)‐(VIII) wird untersuch Es zeigt sich, daß (II) das Hauptprodukt der Reaktion ist und in Ausbeuten bis zu 70% erhalten werden kann.
Repetitive Set-based Learning Robust Predictive Control for Lur’e Systems (2020)

Robust control of uncertain nonlinear systems subject to constrants often leads to conservatism. Such behaviors can be improved by updating the model of the uncertainty with the data collected during the operation time or by bounding the parameters. This paper proposes an approach to robustly control the discrete-time Lur’e system subject to states and input constraints, where the unknown memoryless nonlinearity is sector-bounded and its Lipschitz constant is assumed to be given. In the first phase of operation, when no data has been collected, a robust MPC controller obtained from solving linear matrix inequalities is used. This formulation is also used to compute the safe region, in which the system can operate safely. After sufficient data has been collected, an upper and lower bound of of the nonlinearity can be constructed by using the Lipschitz constant. A controller based on tube-based MPC is used, which results in less conservatism and provides more flexibility. Data of the nonlinearity can be further updated to reduce uncertainty, and hence, to decrease the size of the tube. Under additional conditions, the controller can safely explore the region outside the safe regions to collect more data of the unknown nonlinearity to improve performance and region of attraction.