gebhart/patrepeval huggingface dataset:
Nomenclature for factors of the swine leukocyte antigen class II system, 2005 (2005)

A systematic nomenclature for the genes and alleles of the swine major histocompatibility complex (MHC) is essential to the development and communication of research in swine immunology. The Swine Leukocyte Antigen (SLA) Nomenclature Committee of the International Society for Animal Genetics (ISAG) has reviewed all of the DNA-sequence information for MHC class II genes, available in GenBank/EMBL/DDBJ databases, and the associated published reports to develop such a systematic nomenclature. This article summarizes the proposed nomenclature, which parallels the World Health Organization's nomenclature for factors of the human MHC. The SLA class II genes expressed on the cell membrane will be noted as SLA-DRA, SLA-DRB1, SLA-DQA, and SLA-DQB1. Nomenclature assignments for all SLA class II GenBank sequences are now noted. The committee will add new SLA class II allele designations, as they are discovered, and will maintain a publicly available list of all recognized genes and alleles using the Immuno Polymorphism Database (IPD). The sequences will be available from the IPD-MHC section of the database which contains non-human MHC sequences (http://www.ebi.ac.uk/ipd/mhc/sla/).
Solid-State Analysis of Polymorphic, Isomorphic, and Solvated Forms of Dirithromycin (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-State Analysis of Polymorphic, Isomorphic, and Solvated Forms of DirithromycinGregory A. Stephenson, Joseph G. Stowell, Pascal H. Toma, Douglas E. Dorman, James R. Greene, and Stephen R. ByrnCite this: J. Am. Chem. Soc. 1994, 116, 13, 5766–5773Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00092a030https://doi.org/10.1021/ja00092a030research-articleACS PublicationsRequest reuse permissionsArticle Views518Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The production of congenital malformations using tissue antisera. V. Fluorescent localization of teratogenic antisera in the maternal and fetal tissue of the rat. (1966)

Summary Teratogenic rat kidney and placental antisera were injected into rats that were eight days pregnant and were sacrificed two and five days later to study the localization of these antisera in the maternal organs and embryonic sites. Both these antisera had specific localization in the basement membrane of the kidney glomeruli, adrenal, liver, spleen and parietal yolk sac membrane. No in vivo localization of teratogenic sera was observed in the young embryo, the trophoblast, the amnion and many other maternal tissues. These studies lend support to two of the three hypotheses that attempt to explain the mechanism of action of teratogenic antisera, namely, 1 ) the interference of the function of the trophoblast, decidua or extraembryonic membranes (in this case, the yolk sac) and 2 ) production of maternal disease which is then reflected in the fetus (localization in many maternal organs). A direct effect on the fetus was not supported by these studies, but was not refuted by them either. Finally, the significance of the hypothesis that yolk sac pathology could result in teratogenesis is discussed, since it could have important implications, not only with regard to antisera-induced malformations but because these findings may be applied to malformations induced by chemicals and other environmental influences.
Exploring super-resolution implementations across multiple platforms (2013)

The performance of many applications, such as video streaming, webcam conferencing, and aerial surveillance, all greatly depend on video quality. A major issue with higher quality video is that either more data bandwidth or storage resources must be dedicated for transferring or storing the video. However, if the low-resolution video is transferred or stored in order to conserve data bandwidth and storage space, super-resolution is a viable solution that can be applied afterwards on the receiving end to rectify the poor quality of the low-resolution video. Super-resolution is an imaging technique that leverages motion blur and multiple low-resolution frames to construct a high-resolution frame. In our paper, we implement and analyze a super-resolution algorithm across multiple platforms ranging from purely hardware to purely software and even a mix of both hardware and software. More specifically, we examine the performance for a field-programmable gate array (FPGA) implementation on two different FPGAs, a software/hardware solution on a FPGA with a soft core processor, a general purpose graphics processing unit (GPGPU) implementation, and a MATLAB implementation. Overall, we found that the GPGPU provides the best overall performance with up to 29 FPS with 35 iterations of the super-resolution algorithm. A high-performance FPGA can have comparable performance and rival the GPGPU in some cases. One of the interesting results was that the hardware/software FPGA combination performed worse than the pure software implementation.
Integrated Web enabled control system design methodology (2005)

The ubiquity of the Internet infrastructure has revolutionized the industrial enterprise environment enabling the provision of advanced services, such as Web enabled configuration, maintenance and management of the industrial manufacturing processes. Thus the trend towards distributed systems is further enhanced. In order to best exploit the Web infrastructure in the industrial environment an integrated control system design methodology is needed. This paper presents a proposed architecture in the industrial environment comprising function blocks for code distribution, a special model for devices, an integrated environment for the Web enabled functionalities as well as an associated methodology.
Palladacyclopentadienyl complexes bearing purine‐based N‐heterocyclic carbenes: A new class of promising antiproliferative agents against human ovarian cancer (2019)

A complete protocol for the synthesis of new palladacyclopentadienyl complexes with purine‐based carbenes as supporting ligands is described. The new organometallic compounds were exhaustively characterized using NMR and infrared spectroscopies and elemental analysis. The single‐crystal X‐ray structure of complex 2b coordinating also a triphenylphosphine was resolved. Some of these complexes showed an antiproliferative activity comparable to or better than that of cisplatin on two human ovarian cancer lines: A2780 (cisplatin‐sensitive) and A2780cis (cisplatin‐resistant). Moreover, for complexes 2 and 3 (coordinating one purine‐based N‐heterocyclic carbene ligand and one phosphine) the cytotoxicity is associated with an evident induction of apoptosis. Finally, complexes 3 , bearing one purine‐based N‐heterocyclic carbene ligand and one 1,3,5‐triaza‐7‐phosphaadamantane, proved practically inactive on non‐tumour fibroblast cells (MRC‐5).
Seeing around corners with edge-resolved transient imaging (2020)

Non-line-of-sight (NLOS) imaging is a rapidly growing field seeking to form images of objects outside the field of view, with potential applications in autonomous navigation, reconnaissance, and even medical imaging. The critical challenge of NLOS imaging is that diffuse reflections scatter light in all directions, resulting in weak signals and a loss of directional information. To address this problem, we propose a method for seeing around corners that derives angular resolution from vertical edges and longitudinal resolution from the temporal response to a pulsed light source. We introduce an acquisition strategy, scene response model, and reconstruction algorithm that enable the formation of 2.5-dimensional representations-a plan view plus heights-and a 180<sup>∘</sup> field of view for large-scale scenes. Our experiments demonstrate accurate reconstructions of hidden rooms up to 3 meters in each dimension despite a small scan aperture (1.5-centimeter radius) and only 45 measurement locations.
A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trials (2014)

Background:The statistical analysis of nasal provocation tests is very complex.We compared the conventional analysis with the maximally selected test statistics and the hierarchical ordered logistic model. Methods:We re-analyzed data from a trial with 112 patients suffering from grass pollen allergy.The patients had been randomized to receive either intralymphatic immunotherapy (ILIT) or subcutaneous immunotherapy (SCIT). Results:The conventional analysis indicated that the logarithmized ratio between the pre-and the post-treatment threshold concentration was significantly lower for ILIT than for SCIT.The maximally selected test statistics was used to test different threshold symptom scores that would imply positive clinical symptoms at the given allergen concentration.A threshold score of 3 maximised the difference in improvement between the ILIT and the SCIT groups.The hierarchical ordered logistic model does not take threshold allergen concentrations as the basis for analysis, but the single scores measured at each concentration.This approach simultaneously considers the treatment effect (ILIT versus SCIT), the time effect (pre-versus post-treatment), and the dose effect (different allergen concentrations).The hierarchical ordered logistic model revealed that the clinical improvement was greater after ILIT than after SCIT.
Attention-Set Based Metric Learning for Video Face Recognition (2017)

Face recognition has made great progress with the development of deep learning. However, video face recognition (VFR) is still an ongoing task due to various illumination, low-resolution, pose variations and motion blur. In this paper, we propose a novel Attention-Set based Metric Learning (ASML) method for VFR. It is a promising and generalized extension of Maximum Mean Discrepancy with Memory Attention Weighting inspired by Neural Turing Machine. ASML can be naturally integrated into Convolutional Neural Networks, resulting in an end-to-end learning scheme. Our method achieves state-of-the-art performance for the task of video face recognition on three widely used benchmarks including YouTubeFace, YouTube Celebrities and Celebrity-1000.
Untersuchung der molekularen Erkennung von Aminosäuren durch Cyclopeptide mit reflektometrischer Interferenzspektroskopie (1998)

Bei der Suche nach selektiven Rezeptoren besteht ein vielversprechender Ansatz in der Immobilisierung von Cyclopeptiden auf Sensoroberflächen (siehe Bild) und anschließender Detektion niedermolekularer Analyte durch die reflektometrische Interferenzspektroskopie (RIfS). Diese innovative Methode bietet in Verbindung mit der kombinatorischen Chemie ein großes Potential für Anwendungen in der Sensorik.
Knowledge sharing in change management : a case study in the French railways company (2010)

International audience
Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. (2003)

In this second trial, induction chemotherapy with carboplatin and paclitaxel followed by TFHX chemoradiotherapy results in high survival and progression-free survival. The reduction in radiation dose did not compromise survival or disease control compared with our prior study using higher radiation doses. Data continues to support definitive evaluation of this approach.
Role of Quinone Intermediates as Electron Shuttles in Fenton and Photoassisted Fenton Oxidations of Aromatic Compounds (1997)

Fenton and related reactions are potentially useful oxidation processes for destroying toxic organic compounds in water. In these reactions, H2O2 is combined with Fe(II) or Fe(III) in the presence or absence of light to generate hydroxyl radicals (HO•). A relatively neglected area of research is the influence of organic species on the reactivity of iron, and hence on the rate or course of the reaction. This study examined the oxidation of phenol (2 mM) by Fenton systems in the dark (Fe3+/H2O2, Fe2+/H2O2, and mixed Fe3+/Fe2+/H2O2 systems) and under UV/visible light (Fe3+/H2O2/hν). Reactions were conducted at an initial pH of 2.8, with H2O2 in excess and iron in catalytic concentrations. In all cases, the reactions display autocatalysis. In dark reactions, the lag phase decreases (a) with increasing total iron concentration, [Fe]T; (b) as initial [Fe2+] increases when [Fe]T is held constant; (c) in proportion to the amount of hydroquinone (1,4- or 1,2-) added; and (d) in proportion to the amount of quinones (1,4-benzoquinone or 5-hydroxy-1,4-naphthoquinone [juglone]) added. The hydroquinones reduce Fe3+ to Fe2+. An important result is the finding that quinones serve as electron-transfer catalysts between dihydroxycyclohexadienyl radicalthe HO• adduct of phenoland Fe3+ by way of a semiquinone radical. This conclusion is supported by simulations with a kinetic model employing known and proposed steps. In irradiated solutions, the lag phase decreases with decreasing wavelength (480−300 nm; 10 nm band-pass). A cause of light initiation, especially above ∼410 nm where photolysis of Fe3+ and/or H2O2 is negligible, is direct photolysis of quinones to HO• and semiquinone radicals, which subsequently reduce Fe3+ and re-form the quinone. Thus, quinones play an important catalytic role in Fenton oxidation of aromatic compounds.
Surfactant‐free Fabrication of Fullerene C60 Nanotubules Under Shear (2016)

Abstract A method for controlling the self‐assembly of fullerene C 60 molecules into nanotubules in the fcc phase, devoid of entrapped solvent, has been established in a thin film microfluidic device. The micron length C 60 nanotubules, with individual hollow diameters of 100 to 400 nm, are formed under continuous flow processing during high shear micromixing of water and a toluene solution of the fullerene, in the absence of surfactant, and without the need for further down‐stream processing. TEM revealed pores on the surface of the nanotubes, and the isolated material has a much higher response to small molecule sensing than that for analogous material formed using multistep batch processing.
Attenuation of adenosine receptor‐mediated vasorelaxation by L‐NAME in mouse aorta (2006)

In BALB/c mouse thoracic aorta with intact endothelium, adenosine and its analogs produce a dose‐response (DR) relaxation with a rank order of potency favoring A 2B (NECA&gt;CAD&gt;adenosine&gt;&gt; CGS 21680; Talukder et al. LB4, FASEB J. 13(3), 1999). This was further supported by the fact that the A 2B ‐receptor antagonist, alloxazine shifted DR to right for NECA. However, this study did not investigate the role of endothelium in adenosine‐mediated relaxation of mouse aorta. Thus, the present study was conducted to investigate the role of endothelium in adenosine receptor‐mediated relaxation. In organ bath studies, in intact endothelium, the EC 50s for NECA, CAD and adenosine were found to be 0.05, 1.3 and 3.1 x 10 −4 M, respectively. However, in the absence of endothelium, the EC 50s for NECA, CAD and adenosine were; 0.098, 1.5 and 0.12 x 10 −4 M, respectively indicating a shift in DR to the right. The intactness of endothelium in aortic tissue was tested with acetylcholine. NECA‐induced DR relaxation was significantly blocked by L‐NAME (10 −4 M) in endothelium‐intact tissues; whereas no inhibition was found in endothelium‐denuded tissues. Moreover, the involvement of NO was confirmed by measuring total nitrites and nitrates (NOx) in endothelium‐intact and ‐denuded aorta. NOx levels with L‐NAME (10 −4 M) alone and in combination with L‐arginine (10 −4 M) were 59% and 96%, respectively with respect to control (NECA+PE, p&lt;0.05). These data demonstrate that adenosine‐receptor mediated relaxation in mouse aorta is partially dependent on endothelium through adenosine A 2B ‐receptor. (Supported by HL 027339)
Investigation of evanescent coupling between SOI waveguides and heterogeneously-integrated III&#x2013;V pin photodetectors (2009)

Integrating III-V materials on Si is a promising candidate to realize both passive and active optical functions on a single silicon chip. We have developed this heterogeneous integration technology by means of an adhesive die-to-wafer bonding process under a low temperature. In this paper, efficient evanescent coupling between SOI waveguides and heterogeneously-integrated III-V pin photodetectors is proposed. The serious absorption by p-InGaAs and metal contact layers are greatly reduced by introducing a central opening on these layers. The thickness of the i-InGaAs layer is also optimized towards efficient absorption.
Symmetry breaking in induced-charge electro-osmosis over polarizable spheroids (2007)

We study the induced-charge electro-osmotic flow around a stationary polarizable dielectric spheroid in the presence of a uniform arbitrarily oriented external electric field. A Robin-type condition connecting the respective electric potentials within the dielectric solid and the bulk electro-neutral solution is highlighted in formulating the macroscale description for the limit of thin electric double layers and low potentials. The results illustrate symmetry breaking phenomena in the ensuing flow and demonstrate qualitative differences associated with variations of the dielectric constant. We briefly discuss the potential impact of these differences on the rotation of freely suspended spheroids.
Development of 3D Monte Carlo simulations for predicting multilayer geometry of pit-type EUV defects (2013)

The EUV community has come to the conclusion that completely eliminating EUV mask defects will be nearly impossible in the near future. Instead the industry trend is to develop high performance optical simulations of the multilayer coating in order to compensate for the defects during manufacturing. In order for these simulations to be accurate the full multilayer structure of the EUV defect should be known. Currently there is no usable 3D method of simulating pit-type defects as they are relaxed during the energetic deposition of the Mo/Si multilayer. Current approximations used to model the defect's propagation are poor and have many shortcomings. Monte Carlo simulations of thin film growth are explored for this usage. They are validated using experimental data of a STEM cross section of a multilayer pit-type defect. Monte Carlo methods allow a full 3D representation of the system and have the advantage of great flexibility in deposition conditions and flux distributions. The Solid-on-Solid aggregation model is used to deposit particles onto initial substrate defects; this model does not allow overhanging particles, which replicates the smooth growth of ion-beam deposition well. Surface diffusion is simulated using Boltzmann statistics with activation energies of diffusion biased by local geometry. The growths are compared by observing the aspect ratio of the defect as a function of film thickness; the aspect ratio is defined as the depth of the defect divided by its full width at half maximum. Good fitting is observed for initial defect templates created from atomic force microscopy scans of observed initial defects. More rigorous tests of accuracy are also performed by comparing simulation predictions to AFM scans of the ending multilayer.
OPIOID ANTAGONISTS IN THE TREATMENT OF ALCOHOL DEPENDENCE: CLINICAL EFFICACY AND PREVENTION OF RELAPSE (1996)

Placebo-controlled studies have demonstrated that patients treated with opioid antagonists had fewer drinking days, lower rates of resumed heavy drinking, and reduced alcohol craving, when compared with placebo-treated patients. Patients who received an opioid antagonist were also less likely to drink heavily if they sampled alcohol during treatment. One study also demonstrated that patients who were treated with the opioid antagonist naltrexone had lower serum aspartate aminotransferase and alanine aminotransferase levels than placebo-treated patients. This is consistent with self-reported decreases in alcohol consumption. These patients also had less severe alcohol-related problems than placebo-treated patients, as indicated by the Addiction Severity Index. Opioid antagonists might act by reducing the reinforcing effects of alcohol and the incentive to drink. These agents, when combined with comprehensive treatment programmes, are an effective adjunctive treatment for alcohol-dependent patients.
A data link control protocol for LEO satellite networks providing a reliable datagram service (1995)

A data link control protocol for low earth orbit satellite networks has been developed to overcome throughput limitations inherent in event-based positive acknowledgment automatic-repeat-request class protocols. This was accomplished by relaxing a reliability constraint, specifically, the in-sequence delivery constraint. This relaxation results in a new class of link layer service, that of reliable datagram, and permits a fresh approach to link layer protocol design. The authors present one such protocol, the low altitude multiple satellite data link control (LAMS-DLC) protocol. They derive the throughput efficiency of LAMS-DLC and compare the results with HDLC (selective reject). The analysis is verified using an event-based simulation. Measurements suggest that LAMS-DLC provides near optimal throughput efficiencies in the target environment, while using significantly less buffer space than that required for HDLC-SREJ.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interface Trap Effects on the Hot-Carrier Induced Degradation of MOSFETs during Dynamic Stress (1987)

Foundry and hardened n-channel MOSFETs were stressed with dynamic AC pulses and with static DC voltages. The pre-radiation hot-carrier induced degradation is identical for devices from both processes when subjected to static stress, but when subjected to dynamic stress, the degradation is much more severe for the hardened devices. The data suggest that the degradation is strongly influenced by the pulse structure and it is proposed that the initial density of interface traps may be responsible for the enhancement in degradation exhibited by the hardened devices following dynamic stress.