gebhart/patrepeval huggingface dataset:
Functional glycosylation of human podoplanin: Glycan structure of platelet aggregation‐inducing factor (2007)

Podoplanin (Aggrus) is a mucin-type sialoglycoprotein that plays a key role in tumor cell-induced platelet aggregation. Podoplanin possesses a platelet aggregation-stimulating (PLAG) domain, and Thr52 in the PLAG domain of human podoplanin is important for its activity. Endogenous or recombinant human podoplanin were purified, and total glycosylation profiles were surveyed by lectin microarray. Analyses of glycopeptides produced by Edman degradation and mass spectrometry revealed that the disialyl-corel (NeuAc alpha2-3Gal beta l-3(NeuAc alpha2-6)GalNAc alpha l-O-Thr) structure was primarily attached to a glycosylation site at residue Thr52. Sialic acid-deficient podoplanin recovered its activity after additional sialylation. These results indicated that the sialylated Corel at Thr52 is critical for podoplanin-induced platelet aggregation.
The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium (2022)

Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim of this study was to explore the effect that CBD exerts on the adenosinergic system of paced left atria isolated from obese type Zucker Diabetic Fatty (ZDF) rats, maintained on diabetogenic rat chow, received 60 mg/kg/day CBD or vehicle <i>via</i> gavage for 4 weeks. We found that N6-cyclopentyladenosine (CPA), a relatively stable and poorly transported A1 adenosine receptor agonist, elicited a significantly weaker response in the CBD-treated group than in the vehicle-treated one. In contrast, adenosine, a quickly metabolized and transported adenosine receptor agonist, evoked a significantly stronger response in the CBD-treated group than in the vehicle-treated counterpart (excepting its highest concentrations). These results can be explained only with the adenosine transport inhibitory property of CBD (and not with its adenosine receptor agonist activity). If all the effects of CBD are attributed to the interstitial adenosine accumulation caused by CBD in the myocardium, then a significantly increased adenosinergic activation can be assumed during the long-term oral CBD treatment, suggesting a considerably enhanced adenosinergic protection in the heart. Considering that our results may have been influenced by A1 adenosine receptor downregulation due to the chronic interstitial adenosine accumulation, an adenosinergic activation smaller than it seemed cannot be excluded, but it was above the CBD-naïve level in every case. Additionally, this is the first study offering functional evidence about the adenosine transport inhibitory action of CBD in the myocardium.
Temperature-Dependent Crystal Field and Hyperfine Interactions (1965)

The effects of temperature variation on the spin-Hamiltonian parameters of several paramagnetic ions bound in simple crystals have been measured by magnetic-resonance techniques. Whenever possible the data have been analyzed for implicit (thermal-expansion) and explicit (lattice-vibration) temperature dependences using isothermal volume dependences determined in earlier hydrostatic-pressure experiments. In MgO the $g$ shifts of two $F$-state ions, ${\mathrm{V}}^{2+}$ and ${\mathrm{Cr}}^{3+}$, increase and the cubic-field splittings of two $S$-state ions, ${\mathrm{Mn}}^{2+}$ and ${\mathrm{Fe}}^{3+}$, decrease with increasing temperature almost exactly as would be expected from thermal expansion alone. The axial crystalline-field splitting of locally compensated ${\mathrm{Cr}}^{3+}$ ions also increases with temperature at a rate attributable primarily to thermal expansion. The absence of appreciable explicit temperature dependence of crystalline-field parameters in MgO is consistent with an effective point-charge model for the source of the lattice potential and cubically symmetric lattice vibrations. In zinc blende, however, the cubic-field splitting of ${\mathrm{Mn}}^{2+}$ decreases more rapidly with rising temperature than may be accounted for by thermal expansion alone, presumably because of failure of the point-charge approximation. The hyperfine couplings of ${({\mathrm{V}}^{51})}^{2+}$ and ${({\mathrm{Mn}}^{55})}^{2+}$ in MgO decrease with increasing temperature, whereas a much smaller increase would be expected due to thermal expansion. Similar explicit variations of the ${({\mathrm{Mn}}^{55})}^{2+}$ hyperfine interaction are found in ZnS, ZnO, CdTe, and KMg${\mathrm{F}}_{3}$. The effect may be approximately represented by a power law of the form $A(T)=A(0)(1\ensuremath{-}C{T}^{n})$ where $n\ensuremath{\sim}\frac{3}{2}$. The significance of this result for nuclear-magnetic-resonance studies of concentrated magnetic materials is indicated. The general nature of the explicit temperature dependence is discussed but no detailed theoretical analysis is possible at this time.
On the geometric ergodicity of hybrid samplers (2003)

In this paper, we consider the random-scan symmetric random walk Metropolis algorithm (RSM) on ℝ d . This algorithm performs a Metropolis step on just one coordinate at a time (as opposed to the full-dimensional symmetric random walk Metropolis algorithm, which proposes a transition on all coordinates at once). We present various sufficient conditions implying V -uniform ergodicity of the RSM when the target density decreases either subexponentially or exponentially in the tails.
Root Cause Analysis of Product Service Failure Using Computer Experimentation Technique (2013)

Improvement of product quality and reliability following field failures of products is a well-researched area.The feedback from the service in the form warranty / field performance is important in guiding design and manufacturing changes.Traditionally, efforts in this area have been limited to analysis of warranty data for evaluating warranty policies, estimating field reliability, predicting failures etc.Also some research has been done on performing corrective actions in manufacturing via process adjustments by linking warranty failures with manufacturing Key Control Characteristics (KCCs).However there is also need to develop the systematic approach of doing Root Cause Analysis (RCA) and Corrective Actions in design.This research proposes a novel methodology of performing RCA and CA in design by linking warranty failures with the product design parameters such as Geometric Dimensioning and Tolerance (GD&T).An analytical approach based on computer experimentation technique performs effective Root Cause Analysis (RCA) of product failures by linking warranty failure modes with the design parameters and identifies the analytical relationship between them.The method focuses on identifying root cause(s) to address in tolerance product design faults.Warranty failures modes are represented by Key Failure Characteristics (KFCs) and the geometrical design parameters are represented by Key Product Characteristics (KPCs).The proposed methodology establishes the analytical relationship between the KFCs and KPCs using variation mechanistic models to identify the dimensional variations which caused the failure.A case study on automotive ignition switch demonstrates the methodology.
Abstract 14783: Association of Daily Step Count and Resting Heart Rate With Right Ventricular Function in Pulmonary Arterial Hypertension (2020)

Introduction: Remote activity monitoring may provide new insight into behavioral choices and exercise capacity in pulmonary arterial hypertension (PAH). Here, we report baseline data from a randomized behavioral intervention (NCT03069716) to increase step counts in PAH. Hypothesis: Higher daily step count and lower resting heart rate (RHR) are associated with better right ventricular (RV) function. Methods: We recruited functional class I-III patients with idiopathic, heritable, or connective tissue disease-associated PAH on stable therapy. Participants were provided a Fitbit Charge 3 device and monitored for two weeks as a run-in period to the trial. The 6MWD test and echocardiogram were performed at baseline. RV function was assessed by tricuspid annular plane systolic excursion (TAPSE) and fractional area change (FAC). We conducted linear regression to examine associations between daily step count and RHR with RV function, adjusted for age, sex, and BMI. Results: In total, 42 subjects completed the run-in period (48 ± 11 years, 86% female, 64% functional class II). PAH etiology was 76% idiopathic, 17% heritable, and 7% connective tissue disease. Average daily step count, RHR, and 6MWD were 4718 ± 3521 steps, 72 ± 10 beats per minute, and 424 ± 106 meters, respectively. Only 2.9% of days monitored had missing data. Daily step count (Beta 0.37mm per 1,000 steps; p = 0.039) and RHR (Beta -0.19mm per beat; p = 0.017) were associated with TAPSE ( Figure ), and daily step count was associated with FAC (Beta 1.1% per 1,000 steps; p = 0.01). The 6MWD was modestly associated with daily step count (r = 0.35; p = 0.028) but not associated with RV function (p &gt; 0.05). Conclusions: Remote activity monitoring is feasible in PAH and may provide important clinical information as an adjunct to clinic-based assessments of exercise capacity. Lower daily step count and a higher RHR are associated with poorer RV function. Interventions to increase daily activity warrant further investigation in PAH.
Preparation and Properties of Lithium Ozonide and the Use of Ammonia in the Preparation of Ozonides (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of Lithium Ozonide and the Use of Ammonia in the Preparation of OzonidesAndrew J. Kacmarek, John M. McDonough, and Irvine J. SolomonCite this: Inorg. Chem. 1962, 1, 3, 659–661Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://pubs.acs.org/doi/10.1021/ic50003a041https://doi.org/10.1021/ic50003a041research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leveraging the geometric properties of on-chip transmission line structures to improve interconnect performance: A case study in 65nm (2013)

Implementation of low energy, low latency transmission line interconnects on a network-on-chip presents the circuit designer with a variety of structural design choices. This work presents a study of the comparative effects of changing the wire geometries on the latency, energy dissipated, area, and noise properties of the transmission lines. These results will aid the engineer in the design and performance analysis of the global interconnect and foster a quantitative understanding of the wave signaling properties in the RLC regime.
Covariance Shaping for Massive MIMO Systems (2019)

The low-rank behavior of massive multiple-input multiple-output (MIMO) channel covariance matrices and its<br> exploitation for pilot decontamination and statistical beamforming are well documented. Existing algorithms, however, rely<br> on signal subspace separation among user equipments (UEs) and, as such, they tend to fail when the distance between UEs<br> becomes small. This paper proposes a solution to this problem via covariance shaping at the UE-side in the case where the<br> UEs are equipped with (a small number of) multiple antennas. The key resides in: i) exploiting general non-Kronecker MIMO<br> channel structures that allow the transmitter to suitably alter the channel statistics perceived by the base station, and ii) sacrificing<br> some spatial degrees of freedom at each UE so as to improve the statistical orthogonality between closely spaced UEs. Numerical<br> results illustrate the sum-rate performance gains of the proposed covariance shaping method with respect to existing ones.
Surface-phonon dispersion investigation of the (1×1)→(5×1) reconstruction of the Ir(100) surface (1991)

High-resolution electron-energy-loss spectroscopy has been used to investigate the dispersion of surface phonons on the unreconstructed (1\ifmmode\times\else\texttimes\fi{}1) and the reconstructed (5\ifmmode\times\else\texttimes\fi{}1) Ir(100) surface. A significant difference in the dispersion properties of the (1\ifmmode\times\else\texttimes\fi{}1) and (5\ifmmode\times\else\texttimes\fi{}1) surfaces is found for both the [011] and the [001] direction. Lattice-dynamical calculations in a second-nearest-neighbor force-constant model fit the experimental results on the (1\ifmmode\times\else\texttimes\fi{}1) surface if a large amount of surface stress is invoked. Our results suggest that the surface stress is the driving force for the surface reconstruction of Ir(100)-(1\ifmmode\times\else\texttimes\fi{}1)\ensuremath{\rightarrow}Ir(100)-(5\ifmmode\times\else\texttimes\fi{}1).
A perceptually tuned sub-band image coder with image dependent quantization and post-quantization data compression (2003)

The authors present a 16-band subband coder arranged as four equal-width subbands in each dimension, It uses an empirically derived perceptual masking model, to set noise-level targets not only for each subband but also for each pixel in a given subband. The noise-level target is used to set the quantization levels in a DPCM (differential pulse code modulation) quantizer. The output from the DPCM quantizer is then encoded, using an entropy-based coding scheme, in either 1*1, 1*2, or 2*2 pixel blocks. The type of encoding depends on the statistics in each 4*4 subblock of a particular subband. One set of codebooks, consisting of less than 100000 entries, is used for all images, and the codebook subset used for any given image is dependent on the distribution of the quantizer outputs for that image. A block elimination algorithm takes advantage of the peaky spatial energy distribution of subbands to avoid using bits for quiescent parts of a given subband. Using this system, high-quality output is obtainable at bit rates from 0.1 to 0.9 bits/pixel, and nearly transparent quality requires 0.3 to 1.5 bits/pixel.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
6 th International Workshop on Dynamic Software Product Lines (DSPL 2012) (2012)

In emerging domains such as ubiquitous computing, service robotics, unmanned space and water exploration, and medical and life-support devices, software is becoming increasingly complex with extensive variation in both requirements and resource constraints. Developers face growing pressure to deliver high-quality software with additional functionality, on tight deadlines, and more economically.
Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α (2017)

A major obstacle in predicting and preventing the development of autoimmune type 1 diabetes (T1D) in at-risk individuals is the lack of well-established early biomarkers indicative of ongoing beta cell stress during the pre-clinical phase of disease. Recently, serum levels of the α cytoplasmic isoform of heat-shock protein 90 (hsp90) were shown to be elevated in individuals with new-onset T1D. We therefore hypothesized that hsp90α could be released from beta cells in response to cellular stress and inflammation associated with the earliest stages of T1D. Here, human beta cell lines and cadaveric islets released hsp90α in response to stress induced by treatment with a combination of pro-inflammatory cytokines including interleukin-1β, tumour necrosis factor-α and interferon-γ. Mechanistically, hsp90α release was found to be driven by cytokine-induced endoplasmic reticulum stress mediated by c-Jun N-terminal kinase (JNK), a pathway that can eventually lead to beta cell apoptosis. Cytokine-induced beta cell hsp90α release and JNK activation were significantly reduced by pre-treating cells with the endoplasmic reticulum stress-mitigating chemical chaperone tauroursodeoxycholic acid. The hsp90α release by cells may therefore be a sensitive indicator of stress during inflammation and a useful tool in assessing therapeutic mitigation of cytokine-induced cell damage linked to autoimmunity.
Reagents for Astatination of Biomolecules:  Comparison of the in Vivo Distribution and Stability of Some Radioiodinated/Astatinated Benzamidyl andnido-Carboranyl Compounds (2003)

An investigation has been conducted to assess the in vivo stability of a series of astatinated benzamides and astatinated nido-carborane compounds in mice. It was hypothesized that the higher bond strength of boron-astatine bonds in the nido-carboranes might provide increased stability toward in vivo deastatination. Four tri-n-butylstannylbenzamides were prepared for radiohalogenation and evaluation in vivo. Those compounds were N-propyl-4-(tri-n-butylstannyl)benzamide 1a, N-propyl-3-(tri-n-butylstannyl)benzamide 2a, ethyl 4-tri-n-butylstannylhippurate 3a, and 4-tri-n-butylstannyl-hippuric acid 4a. Seven mono-nido-carboranyl derivatives were prepared for radiohalogenation and in vivo evaluation. Four of the seven mono-carboranyl derivatives (5a, 6a, 7a, 13a) contained a 3-(nido-carboranyl)propionamide functionality, and the remaining compounds (8a, 8g, 10a) contained a 4-(nido-carboranyl)aniline functionality. Two additional derivatives (11a, 12a) were prepared that contained bis-(nido-carboranylmethyl)benzene moieties (also referred to as Venus flytrap complexes (VFCs). All benzamide and nido-carborane compounds underwent facile iodination and radiohalogenation, except a 4-(nido-carboranyl)aniline derivative, 8a. Iodination of 8a resulted in a mixture, of which the desired iodinated product was a minor component. Therefore, radiohalogenation was not attempted. It is believed that the mixture of products is due to the presence of a thiourea bond. Previous studies have shown that thiourea bonds can interfere with halogenation reactions. In vivo comparisons of the compounds were conducted by co-injection of dual labeled (125/131I and 211At) compounds. Tissue distribution data were obtained at 1 and 4 h postinjection of the radiolabeled compounds, as that was sufficient to determine if astatine was being released. Stability of the astatinated compound was assessed by the difference in concentration of radioiodine and astatine in lung and spleen. All of the benzamides were found to undergo rapid deastatination in vivo. The nido-carborane derivatives appeared to be slightly more stable to in vivo deastatination; however, they had long blood residence times. The surprising finding was that the VFC derivatives did not release 211At in vivo, even though they rapidly localized to liver. This finding provides encouragement that stable conjugates of 211At may be attained if appropriate modifications of the VFC can be made to redirect their excretion through the renal system.
Integrated heaters for the thermal tuning of Bragg grating filters on silicon‐on‐insulator rib waveguides (2011)

Abstract The thermal tuning of a Bragg grating filter on silicon‐on‐insulator rib waveguides has been demonstrated with integrated resistive heaters.The thermal sensitivity is 82 pm/×°C with an efficiency of 4.5 nm/W. A technique for indirectly measuring the temperature of the integrated heaters is also demonstrated. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:672–676, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25768
La détermination systématique des sous-groupes spatiaux et des changements de repère conventionnel des groupes spatiaux (1978)

After usual properties of space subgroups have been described, the sufficient condition is given for a space group g to be any subgroup of a space group G: the translation vectors a, b, c of the conventional unit cell of g(o,a,b,c) must belong to the lattice of G and the 'generators' of equivalent general positions of g must be enclosed in the set of general positions of G. In order to verify this criterion, it is necessary to obtain the coordinates of general positions of g in the reference standard setting of G(O,A,B,C); it is necessary to know the coordinates of origin o and the components of vectors a, b, c in terms of the reference setting (O,A,B,C). Then, all the possibilities of a space group of standard symbol \cal s being any subgroup of a space group of standard symbol \cal l can be characterized. Classification of the standard settings of subgroups is established: different settings of the same subgroup and settings of conjugated subgroups.
Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer (2016)

We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.
Light source target design for vision-based blended wing body UAV recovery (2008)

This paper is concerned with the light source target design for vision-based blended wing body UAV recovery. A terminal guidance for the blended-wing UAV recovery relies on visual information from light source targets. The proposed target is designed to provide attitude and position of the blended wing UAV. HSI based segmentation is employed for the target detection. The performance of the proposed target design and detection algorithm is evaluated through ground experiments.
Bit and Power Loading Approach for Broadband Multi-Antenna OFDM System (2007)

In this work, we have studied bit and power allocation strategies for multi-antenna assisted Orthogonal Frequency Division Multiplexing (OFDM) systems and investigated the impact of different rates of bit and power allocations on various multi-antenna diversity schemes. It is observed that, if we cannot find the exact Signal to Noise Ratio (SNR) thresholds due to different reasons, such as reduced Link Adaptation (LA) rate, Channel State Information (CSI) error, feedback delay etc., it is better to fix the transmit power across all sub-channels to guarantee the target Frame Error Rate (FER). Otherwise, it is possible to use adaptive power distribution to save power, which can be used for other purposes, or to increase the throughput of the system by transmitting higher number of bits.<br/>We also observed that in some scenarios and in some system conditions, some form of simultaneous bit and power allocations across OFDM sub-channels are required together for efficient exploitation of wireless channel.