gebhart/patrepeval huggingface dataset:
Development and modeling of design and process guidelines for FDM structures for the partial reinforcement of hybrid structures (2019)

The mechanical properties of thin-walled plastic components are limited. One approach to improve the strength or stiffness of these components is to reinforce the thin-walled areas with an individually adapted Fused Deposition Modeling structure. Fused Deposition Modeling (FDM) is one of the most commonly used additive manufacturing processes. This process is characterized by the deposition of a fused, thermoplastic filament. Depending on the form of the reinforcement structure, the resulting hybrid structure should show higher strength or stiffness. The objective of the project is to determine constructive design and process guidelines for FDM structures. The FDM structure is to be used as a partial reinforcement for lightweight components and be adapted to the respective load conditions. Because of the lightweight application, the FDM structure should also have the lowest possible weight. The optimization of the FDM parts for different load cases is realized by adapting the design parameters. These parameters influence the layer generation and therefore also the inner structure of the FDM parts.In preliminary studies, the manufacturing restrictions of the FDM process are defined. The specimens are manufactured based on the Design of Experiments. To determine the static strength properties, different tests (tensile, compression, flexural, torsion and impact) are carried out. The investigations show that the filling strategy affects the mechanical properties. As a result of the investigations, design and process guidelines for the FDM structures are established according to the load conditions.
Aberrant CYP1A1 Induction: Discrepancy of CYP1A1 mRNA and Aryl Hydrocarbon Hydroxylase Activity in Mutant Cells of Mouse Hepatoma Line, Hepa‐1 (1994)

We have isolated new benzo[a]pyrene-resistant clones, cl-21 and cl-32, of the mouse hepatoma line, Hepa-1. CYP1A1-dependent aryl hydrocarbon hydroxylase activity is not inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene in these two cell lines. However, mRNA of CYP1A1 is inducible in cl-21 and cl-32 cells, as in the wild-type cells, in spite of an undetectable level of cytosolic Ah receptor. The cl-21 cDNA of Cyp1a-1 was found to have a single mutation leading to an amino acid substitution from Leu (118) to Arg (118). However, the CYP1A1 protein band was not detected on Western immunoblots. The cDNA of cl-32 was found to have a single mutation leading to an amino acid change from Arg (359) to Trp (359). The presence of the mature protein in cl-32 was confirmed by Western blot analysis. Somatic cell hybridization experiments demonstrated that the phenotype of cl-21 and cl-32 is recessive and that these clones belong to the same complementation group. These data suggest that there may be a non-Ah receptor-mediated mechanism of CYP1A1 induction.
Induction of p53 suppresses chronic myeloid leukemia (2017)

Chronic myeloid leukemia (CML) is characterized by the chromosomal translocation 9;22, known as the Philadelphia chromosome (Ph), which produces the BCR-ABL fusion tyrosine kinase. Although well-managed by BCR-ABL tyrosine kinase inhibitors (TKIs), treatment fails to eliminate Ph + primitive progenitors, and cessation of therapy frequently results in relapse. The p53 protein is an important regulator of cell cycle and apoptosis. The small molecules MI-219 target the interaction between p53 and its negative regulator HDM2, leading to its stabilization and activation. We show that treatment with MI-219 reduced the number of CML cells in both in vitro and in vivo settings but not that of normal primitive progenitors, and activated different gene signatures in CML potentially explaining the differential impact of this agent on each population. Our data suggest that a p53-activating agent may be an effective approach in the management and potential operational cure of CML.
Advancing the Theory and Utility of Holographic Reduced Representations (2025)

In this thesis, we build upon the work of Plate by advancing the theory and utilityof Holographic Reduced Representations (HRRs). HRRs are a type of linear, associativememory developed by Plate and are an implementation of Hinton’s reducedrepresentations. HRRs and HRR-like representations have been used to model humanmemory, to model understanding analogies, and to model the semantics of naturallanguage. However, in previous research, HRRs are restricted to storing and retrievingvectors of random numbers, limiting both the ability of HRRs to model humanperformance in detail, and the potential applications of HRRs. We delve into the theory ofHRRs and develop techniques to store and retrieve images, or other kinds of structureddata, in an HRR. We also investigate square matrix representations as an alternative toHRRs, and use iterative training algorithms to improve HRR performance. This workprovides a foundation for cognitive modellers and computer scientists to explore newapplications of HRRs.
Expression of cytokine signal transduction components in the postnatal mouse retina. (2003)

In the neonatal mouse retina, signaling components of the Jak-STAT pathway and ERK2 are differentially expressed. All cytokine signaling components included in this study are expressed in the differentiated inner retina as well as in cells occupying the ventricular zone, suggesting that both postmitotic neurons and proliferative progenitors may directly respond to CNTF-like cytokines during postnatal development. The distribution of cytokine signaling pathway components in the adult mouse retina is consistent with previous findings that ganglion cells and Müller glia are the primary target cell types for CNTF.
Numerical Simulation of Fatigue Crack Initiation and Propagation for In-plane Gusset Welded Joints (2005)

Welded built-up steel structures in service encounter many accidents caused by fatigue, and it is important for maintenance of social foundations and safeness to estimate their fatigue lives quantitatively.By considering that fatigue cracks cannot grow without the accumulation of alternating tensile / compressional plastic strain, one of authors identified that the effective stress intensity factor range ΔKRPG based on the Re-tensile Plastic zone Generating (RPG) load which represents the fatigue crack driving forces, and suggests that ΔKRPG should be applied as the parameter in order to describe the fatigue crack growth behavior. For predicting fatigue crack initiation and propagation, numerical simulation code “FLARP” based on ΔKRPG was developed.In this paper, it is confirmed that fatigue life estimation by FLARP gives accurate results by comparing the estimated fatigue crack growth curves with the experimental results for in-plane gusset welded joints which are used in many welded steel structures. Moreover, the effect of induced bending moment due to misalignment for the fatigue strength is investigated by the numerical simulations.
Spectrofluorimetric determination of fexofenadine hydrochloride in pharmaceutical preparation using silver nanoparticles (2010)

A novel sensitive fluorimetric method was investigated for the assay of fexofenadine hydrochloride (FEX) using silver nanoparticles (NPs) as a fluorescence probe. The NPs, which were prepared by chemical reduction of silver nitrate with sodium borohydride (reducing agent) in aqueous solution (without organic stabilizers) were water soluble, stable and had narrow emission band. The addition of drug to NPs solution caused considerable quenching of the emission band of silver NPs, which was likely due to the complexation of the drug to silver NPs. Under the optimum conditions, the quenched fluorescence (FL) intensity was linear with the concentration of FEX in the range of 1 × 10−7 to 2.5 × 10−5 mol L−1 (0.9985) with a detection limit of 1.2 × 10−8 mol L−1. The quenching mechanism of the studied drug on the emission band of silver NPs was explained by Stern–Volmer law. The developed method was applied to FEX determination in a pharmaceutical formulation (allegra tablets) and biological fluids (human serum and urine).
Supplementary Table 2 from Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer (2023)

&lt;p&gt;PDF file - 51K&lt;/p&gt;
Fiber Bragg Grating Interrogation Systems (2011)

Fiber Bragg Gratings are structures with remarkable characteristics that have induced new qualitative developments in the broad field of optical fiber technology, most notably in optical communications and in optical sensing. When these devices are applied for sensing, the underlying concept is the modulation of the grating Bragg wavelength by the measured and, therefore, a central issue is the sensitive and accurate conversion of the resonant wavelength into a proportional electrical signal with the adequate format for further processing. This topic is broadly known as Fiber Bragg Grating interrogation and is the subject of the present chapter. It is organized in two parts: in the first one, the techniques developed by the scientific community looking for this functionality are reviewed, with emphasis on the identification of general conceptual classes where they fit; in the second part, illustrative and state-of-the-art commercial Fiber Bragg Grating interrogation systems are described.
6. The Population Problem (1990)

The city which in Hamilton's estimate in 1716 had a population of 12,000 accommodated a population of 5,00,000 towards the tum of the 19th Century as estimated by the Police Commissioner of Calcutta. In the same city "with the lanes and bye-lanes", "and industrial area around it infected with murder, the harmony of interlinking relationships which constitute our social and economic System shattered, when lawful authority" was "challenged and the will of the mob" imposed, it appeared to Ghose ...
Novel ionic liquids and plastic crystals utilizing the cyanate anion (2011)

In line with the continuing growth in the use of ionic liquids, and an ever-present requirement for high conductivity electrolytes for a range of electrochemical devices, there is a strong demand for the development of novel salts with the required physical properties. Thus, in this work a series of new cyanate-based ionic liquids and organic ionic plastic crystals have been synthesized and their physical properties are reported. Some of the salts form organic ionic plastic crystals with high ionic conductivity, indicating their potential use as solid state electrolytes. It is also shown that the ionic liquids have potential applications in the extraction of transition metal ions or the dissolution of metallic gold.
Efficient calculation of the dispersion diagram of planar electromagnetic band-gap structures by the MoM/BI-RME method (2005)

The characterization of planar electromagnetic band-gap structures requires the calculation of the dispersion diagram of the modes supported by the periodic structure and the phase of the reflection coefficient under plane-wave illumination. We present a novel method for the calculation of the dispersion diagram. The electromagnetic analysis is based on the method of moments/boundary integral-resonant mode expansion (MoM/BI-RME) method and leads to the formulation of a homogeneous matrix problem. The solution of this problem is performed by an iterative procedure: for a given value of the propagation phase constant, the frequency range is scanned to find the frequencies where the field equation has a nontrivial solution. The search of these frequencies is based on the tracking of the eigenvalues in the complex plane, and proved more efficient than other classical methods (direct search of the determinant zeros, singular value decomposition). The reflection coefficient can be readily determined by using the MoM/BI-RME method, already developed for the analysis of the scattering from frequency selective surfaces. The method is applied to the characterization of the classical uniplanar compact photonic-bandgap structure, and analysis results show the accuracy of the method, its efficiency, and its convergence properties.
ChemInform Abstract: VANADIUM(V) PEROXY COMPLEXES. NEW VERSATILE BIOMIMETIC REAGENTS FOR EPOXIDATION OF OLEFINS AND HYDROXYLATION OF ALKANES AND AROMATIC HYDROCARBONS (1983)

Abstract Picolincarbonsäure reagiert im Verhältnis I : l mit V 2 O 5 in H 2 O 2 bei 0 °C zu dem Neutralkomplex (lalund im Verhältnis 2: l zu (IIa).
Model‐Based Reconstructive Elasticity Imaging Using Ultrasound (2007)

Elasticity imaging is a reconstructive imaging technique where tissue motion in response to mechanical excitation is measured using modern imaging systems, and the estimated displacements are then used to reconstruct the spatial distribution of Young's modulus. Here we present an ultrasound elasticity imaging method that utilizes the model-based technique for Young's modulus reconstruction. Based on the geometry of the imaged object, only one axial component of the strain tensor is used. The numerical implementation of the method is highly efficient because the reconstruction is based on an analytic solution of the forward elastic problem. The model-based approach is illustrated using two potential clinical applications: differentiation of liver hemangioma and staging of deep venous thrombosis. Overall, these studies demonstrate that model-based reconstructive elasticity imaging can be used in applications where the geometry of the object and the surrounding tissue is somewhat known and certain assumptions about the pathology can be made.
Abnormal Response of the Proliferation and Differentiation of Growth Plate Chondrocytes to Melatonin in Adolescent Idiopathic Scoliosis (2014)

Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal growth in AIS during the peripubertal period remain unknown. In this cross-sectional case-control study, growth plate chondrocytes (GPCs) were cultured from twenty AIS and ten normal control subjects. Although the MT2 receptor was identified in GPCs from both AIS and controls, its mRNA expression was significantly lower in AIS patients than the controls. GPCs were cultured in the presence of either the vehicle or various concentrations of melatonin, with or without the selective MT2 melatonin receptor antagonist 4-P-PDOT (10 µM). Then the cell viability and the mRNA expression of collagen type X (COLX) and alkaline phosphatase (ALP) were assessed by MTT and qPCR, respectively. In the control GPCs, melatonin at the concentrations of 1, 100 nM and 10 µM significantly reduced the population of viable cells, and the mRNA level of COLX and ALP compared to the vehicle. Similar changes were not observed in the presence of 4-P-PDOT. Further, neither proliferation nor differentiation of GPCs from AIS patients was affected by the melatonin treatment. These findings support the presence of a functional abnormality of the melatonin signaling pathway in AIS GPCs, which might be associated with the abnormal endochondral ossification in AIS patients.
On Determining the Haptic Smoothness of Force-Shaded Surfaces (2000)

Fig.1 Sectional image of stimulus shape. A cylindrical surface, defined by resolution angle α, is interpolated in different ways. The axis of the cylinder is placed along the Z-axis, or toward the subject. d: Max. difference between the polygonal approximation and the true surface. Fig.3 Comparison of interpolation methods. Fig.2 Results of Expriment A. (b) Max. Difference for Threshold Angle
On mining group patterns of mobile users (2003)

Abstract. In this paper, we present a group pattern mining approach to derive the grouping information of mobile device users based on the spatio-temporal distances among them. Group patterns of users are determined by a distance threshold and a minimum duration. To discover group patterns, we propose the AGP and VG-growth algorithms that are derived from the Apriori and FP-growth algorithms respectively. We further evaluate the efficiencies of these two algorithms using synthetically generated user movement data. 1
Iron Accumulation during Cellular Senescence (2004)

Iron accumulates as a function of age and is associated with the pathology of numerous age-related diseases. These changes may be caused by altered iron homeostasis at the cellular level, yet this is poorly understood. Therefore, changes in iron content in primary human fibroblasts were studied in culture models of cellular senescence. Total iron content increased exponentially during cellular senescence, reaching approximately 10-fold higher levels than young cells. Increasing intracellular iron levels through iron-citrate supplementation or decreasing intracellular iron levels using iron-selective chelators had little effect on cellular life span and markers of cellular senescence when used at subtoxic doses. However, accelerating cellular senescence with low-dose H(2)O(2) also accelerated senescence-associated iron accumulation. Delaying cellular senescence with N-tert-butyl-hydroxylamine (NtBHA) attenuated senescence-associated iron accumulation. Furthermore, H(2)O(2) or NtBHA had no effect on iron intracellular levels in immortalized fibroblasts. Thus, iron accumulation is not a cause, but a consequence of normal cellular senescence in vitro. Senescence-associated iron accumulation may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells.
Evaluation and treatment of men with biochemical prostate-specific antigen recurrence following definitive therapy for clinically localized prostate cancer. (2001)

Early detection and monitoring by serum prostate-specific antigen (PSA) measurement has increased the number of men presenting with potentially curable prostate cancer. Most will choose radical prostatectomy or some form of radiation therapy for treatment, but some will have evidence of biochemical disease recurrence following therapy, shown by a rising PSA level without other clinical evidence of disease. Radical prostatectomy involves the removal of all prostate tissue, causing the serum PSA to decline to undetectable levels within four to six weeks following surgery; a subsequent rise in the serum PSA to a detectable level indicates disease recurrence. Patients should be evaluated to assess whether rising PSA levels indicate local recurrence or early metastatic disease. The advantages of salvage radiation, endocrine therapy, and other treatment modalities in local disease recurrence must be weighed against potential side effects and the resulting decrease in quality of life. Radiation therapy does not immediately eradicate all PSA-producing cells; therefore the persistence of a detectable PSA does not necessarily imply residual cancer, but rising PSA levels indicate treatment failure. Salvage surgery can be performed after radiotherapy for the purpose of removing all viable cancer cells, but should be weighed against a higher incidence of surgical complications; cryoablation offers a less invasive therapeutic modality.
Two C3‐Symmetric Dy3III Complexes with Triple Di‐μ‐methoxo‐μ‐phenoxo Bridges, Magnetic Ground State, and Single‐Molecule Magnetic Behavior (2014)

Two series of isostructural C(3)-symmetric Ln(3) complexes Ln(3)⋅[BPh(4)] and Ln(3)⋅0.33[Ln(NO(3))(6)] (in which Ln(III) =Gd and Dy) have been prepared from an amino-bis(phenol) ligand. X-ray studies reveal that Ln(III) ions are connected by one μ(2)-phenoxo and two μ(3)-methoxo bridges, thus leading to a hexagonal bipyramidal Ln(3)O(5) bridging core in which Ln(III) ions exhibit a biaugmented trigonal-prismatic geometry. Magnetic susceptibility studies and ab initio complete active space self-consistent field (CASSCF) calculations indicate that the magnetic coupling between the Dy(III) ions, which possess a high axial anisotropy in the ground state, is very weakly antiferromagnetic and mainly dipolar in nature. To reduce the electronic repulsion from the coordinating oxygen atom with the shortest Dy-O distance, the local magnetic moments are oriented almost perpendicular to the Dy(3) plane, thus leading to a paramagnetic ground state. CASSCF plus restricted active space state interaction (RASSI) calculations also show that the ground and first excited state of the Dy(III) ions are separated by approximately 150 and 177 cm(-1), for Dy(3)⋅[BPh(4)] and Dy(3)⋅0.33[Dy(NO(3))(6)], respectively. As expected for these large energy gaps, Dy(3)⋅[BPh(4)] and Dy(3)⋅0.33[Dy(NO(3)(6)] exhibit, under zero direct-current (dc) field, thermally activated slow relaxation of the magnetization, which overlap with a quantum tunneling relaxation process. Under an applied Hdc field of 1000 Oe, Dy(3)⋅[BPh(4)] exhibits two thermally activated processes with U(eff) values of 34.7 and 19.5 cm(-1), whereas Dy(3)⋅0.33[Dy(NO(3))(6)] shows only one activated process with Ueff =19.5 cm(-1).
Optimizing the Use of Soccer Drills for Physiological Development (2009)

USING SOCCER DRILLS FOR CONDITIONING HAS CONSIDERABLE BENEFITS. HOWEVER, THE PRACTICALITIES OF CONDUCTING SUCH SESSIONS ARE MORE CHALLENGING THAN NON-SOCCER-SPECIFIC CONDITIONING METHODS. THIS ARTICLE EXAMINES FACTORS THAT AFFECT THE PHYSICAL NATURE OF SOCCER DRILLS AND PROVIDES GUIDANCE ON HOW TO OPTIMIZE TRAINING STRUCTURE WHEN USING SOCCER DRILLS FOR PHYSIOLOGICAL DEVELOPMENT.
A systematic review on distributed denial of service attack defense mechanisms in programmable networks (2021)

Summary Design flaws and vulnerabilities inherent to network protocols, devices, and services make Distributed Denial of Service (DDoS) a persisting threat in the cyberspace, despite decades of research efforts in the area. The historical vertical integration of traditional IP networks limited the solution space, forcing researchers to tweak network protocols while maintaining global compatibility and proper service to legitimate flows. The advent of Software‐Defined Networking (SDN) and advances in Programmable Data Planes (PDP) changed the state of affairs and brought novel possibilities to deal with such attacks. In summary, the ability of bringing together network intelligence to a control plane, and offloading flow processing tasks to the forwarding plane, opened up interesting opportunities for network security researchers unlike ever. In this article, we dive into recent research that relies on SDN and PDP to detect, mitigate, and prevent DDoS attacks. Our literature review takes into account the SDN layered view as defined in RFC7426 and focuses on the data, control, and application planes. We follow a systematic methodology to capture related articles and organize them into a taxonomy of DDoS defense mechanisms focusing on three facets: activity level , deployment location , and cooperation degree . From the analysis of existing work, we also highlight key research gaps that may foster future research in the field.