gebhart/patrepeval huggingface dataset:
Cross-domain object recognition by output kernel learning (2012)

It is of great importance to investigate the domain adaptation problem as vision data is now available from a variety of sources. For adapting a classifier, the first problem is how to choose ‘source’ domain. The key issue here is measuring domain similarity. In this paper, we present one of the first studies on ‘domain similarity’ measure in the context of object recognition. We introduce an output kernel divergence as a similarity measure between different data domains, and propose using it as a criterion for domain selection for better recognition accuracy. We also propose a novel domain adaptation method using a vector-valued function with learned output kernels. Fundamentally different from existing work, we focus on the shift in the output kernel space, instead of handling the distribution shift in the input feature space. In addition, those previous methods could also be applied together with ours to improve the performance further. We demonstrate the ability of the proposed model to select and adapt between different domains, and report the state-of-art results on a benchmark data set.
Molecular Characterization ofCampylobacter jejuniClones: A Basis for Epidemiologic Investigation (2002)

A total of 814 isolates of the foodborne pathogen Campylobacter jejuni were characterized by multilocus sequence typing (MLST) and analysis of the variation of two cell-surface components: the heat-stable (HS) serotyping antigen and the flagella protein FlaA short variable region. We identified 379 combinations of the MLST loci (sequence types) and 215 combinations of the cell-surface components among these isolates, which had been obtained from human disease, animals, food, and the environment. Despite this diversity, 748 (92%) of the isolates belonged to one of 17 clonal complexes, 6 of which contained many (318, 63%) of the human disease isolates. Several clonal complexes exhibited associations with isolation source or particular cell-surface components; however, the latter were poorly predictive of clonal complex. These data demonstrate that the clonal complex, as defined by MLST, is an epidemiologically relevant unit for both long and short-term investigations of C. jejuni epidemiology.
Chemo- and biodiversity of microbes associated with pine weevil (Hylobius abietis) (2013)

This thesis is based on three inter-related studies: the first part deals with the microbial consortium, the identification of microbes and their volatiles, the second part deals with the study of bio-chemical control methods of two conifer pests; the pine weevil Hylobius abietis (L.) and the root rot fungi Heterobasidion spp., and the third part describes the production of styrene by a fungus using forest waste.The large pine weevil (Hylobius abietis L.) is an economically important pest insect of conifers in reforestation areas of Europe and Asia. The female weevils protect their eggs from feeding conspecifics by adding frass (mixture of weevil feces and chewed bark) along with the eggs. In order to understand the mechanism behind frass deposition at the egg laying site and to find repellents/antifeedants for pine weevils, microbes were isolated from the aseptically collected pine weevil frass. Microbial produced volatile organic compounds (VOCs) were collected by solid phase micro extraction and analyzed by GC-MS after cultivating them on weevil frass broth. The major VOCs were tested against pine weevils using a multi-choice olfactometer. Ewingella sp., Mucor racemosus, Penicillium solitum, P. expansum, Ophiostoma piceae, O. pluriannulatum, Debaryomyces hansenii and Candida sequanensis were identified as abundant microbes. Styrene, 6-protoilludene, 1-octene-3-ol, 3-methylanisole, methyl salicylate, 2-methoxyphenol and 2-methoxy-4-vinylphenol were the VOCs of persistently isolated microbes. In behavioral bioassay, methyl salicylate, 3-methylanisole and styrene significantly reduced the attraction of pine weevils to their host plant volatiles. Heterobasidion spp. are severe pathogenic fungi of conifers that cause root and butt rot in plants. Bacterial isolates were tested for the antagonistic activity against fungi on potato dextrose agar. Bacillus subtilis strains significantly inhibited the growth of H. annosum and H. parviporum. Styrene is an industrial chemical used for making polymeric products, currently produced from fossil fuel. A strain of Penicillium expansum isolated from pine weevil frass was investigated for the production of styrene using forest waste. Grated pine stem bark and mature oak bark supplemented with yeast extract produced greater amounts of styrene compared to potato dextrose broth.
A Murine Monoclonal Antibody With Potent Neutralization Ability Against Human Adenovirus 7 (2019)

B1-type human adenoviruses (HAdVs) HAdV-3, HAdV-7, and HAdV-55 have caused epidemics in North America, Asia, and Europe. However, to date, no adenovirus vaccines or antiviral drugs have been approved for general use. In the present work, a scFv-phage immune library was constructed and mouse monoclonal antibody (MMAb) 10G12 was obtained through selection. 10G12 is specific for HAdV-7 and binds the hexon loop1 and loop2 (LP12), resulting in strong neutralization activity against HAdV-7. Additionally, it is stable in serum and buffer at various pH values. The findings provide insight into adenovirus and antibody responses and may facilitate the design and development of adenovirus vaccines and antiviral drugs.
Three-dimensional disk-based optical correlator (1994)

A total of 300 templates were stored as angularly multiplexed transmission holograms at multiple spots on a photopolymer disk. A novel correlator architecture is described and demonstrated that correlates all the templates against an input image within one disk rotation (≈ 20 ms). The projected performance of the system is 150,000 templates per disk and a processing rate of approximately 6000 correlations per second.
Prospective Study of Bevacizumab Plus Temozolomide in Patients With Advanced Neuroendocrine Tumors (2012)

Temozolomide and bevacizumab can be safely administered together in patients with advanced NETs, and the combination regimen appears promising for patients with pancreatic NETs. Studies evaluating the relative contributions of these two agents to the observed antitumor activity are warranted.
The Chemistry of the Molten Carbonate Process for Sulfur Oxides Removal from Stack Gases (1974)

In the molten carbonate process a molten eutectic mixture of lithium, sodium, and potassium carbonates removes sulfur oxides from power plant stack gases. The resulting molten solution of alkali metal sulfites, sulfates, and unreacted carbonate is regenerated in a two-step process to the alkali carbonate for recycling. Hydrogen sulfide, which is evolved in the regeneration step, is converted to sulfur in a conventional Claus plant. A 10 MW pilot plant of the process has been constructed at the Consolidated Edison Arthur Kill Station on Staten Island, and startup is underway.
Killing Time: The British Army and its Antagonists in Egypt, 1945–1954 (1994)

(1994). Killing Time: The British Army and its Antagonists in Egypt, 1945–1954. War & Society: Vol. 12, No. 2, pp. 103-126.
Antimicrobial effect of Carvacrol on Aspergillus flavus and reduce expression of aflR gene in the aflatoxin biosynthetic pathway (2020)

Carvacrol was found in essential oils of thyme, oregano, wild bergamot, and some other plants. Although, a wide range of bioactivities such as anticancer, antioxidant, and antimicrobial has been identified for carvacrol, however, among all therapeutic properties it possesses a potent antimicrobial activity. The present study investigates the inhibitory eﬀect of carvacrol as an active compound against the growth of Aspergillus flavus, besides its effect on the expression of aflatoxin-related (aflR) gene. Twelve fungal samples of A. flavus were used and the antimicrobial activity of carvacrol was tested against them using the minimum inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) according to the broth microdilution procedure. The expression of the aflatoxin regulatory (aflR) gene was examined by Reverse Transcriptase polymerase chain reaction (RT-PCR) technique. The results of MIC and MFC tests showed that carvacrol at 0.8 μg/ml and 3.5 μg/ml concentrations displayed antimicrobial activities on A. flavus, respectively. The RT-PCR result indicated that the expression level of aflR gene had decreased to 33% in the presence of carvacrol compared to 67% in the absence of the mentioned active compound. Together the results demonstrated that carvacrol not only exhibited antimicrobial activity against A. flavus but also reduced its gene expression level.
Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models (2017)

Activated erythropoietin (EPO) receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis. However, the significance of EPOR signaling for regulation of macrophages contributing to erythropoiesis has not been fully understood. Here we show that EPOR signaling activation quickly expands both erythrocytes and macrophages <i>in vivo</i> in mouse models of primary and secondary erythrocytosis. To mimic the chimeric condition and expansion of the disease clone in the polycythemia vera patients, we combined Cre-inducible <i>Jak2</i><sup>V617F/+</sup> allele with <i>LysM</i>-Cre allele which expresses in mature myeloid cells and some of the HSC/Ps (<i>LysM</i>-Cre;<i>Jak2</i><sup>V617F/+</sup> mice). We also generated inducible EPO-mediated secondary erythrocytosis models using <i>Alb-Cre, Rosa26-loxP-stop-loxP</i>-rtTA, and doxycycline inducible <i>EPAS1</i>-double point mutant (DPM) alleles (<i>Alb</i>-Cre;DPM mice). Both models developed a similar degree of erythrocytosis. Macrophages were also increased in both models without increase of major inflammatory cytokines and chemokines. EPO administration also quickly induced these macrophages in wild-type mice before observable erythrocytosis. These findings suggest that EPOR signaling activation could induce not only erythroid cell expansion, but also macrophages. Surprisingly, an <i>in vivo</i> genetic approach indicated that most of those macrophages do not express EPOR, but erythroid cells and macrophages contacted tightly with each other. Given the importance of the central macrophages as a niche for erythropoiesis, further elucidation of the EPOR signaling mediated-regulatory mechanisms underlying macrophage induction might reveal a potential therapeutic target for erythrocytosis.
2P1-E10 Highly Precise Control of MRI Compatible Needle Puncture Navigation Robot (2007)

The surgical navigation robot is used in order to position the instrument correctly to the target disease. The development of a MRI (Magnetic Resonance Imaging) compatible navigation robot is also recently started so as to utilize more rich information of the MR imaging. In this research, we discuss about highly precise control of the navigation robot. This robot consists of ultrasonic motors (USM) and nonmagnetic materials. We operate the robot by using the phase difference control circuit which we developed as the driver of the USM and show the control performance by experimental results. In addition, we show the result of the MRI compatibility tests which we inspected using 0.2T open MRI.
The logic of intercellular communication in the immune system (1998)

The collaboration between T and B lymphocytes is used as an example to illustrate how the key features of immune regulation (cell interaction, reciprocal exchange of signals by cell contact, and dependence on soluble cytokines) serve as amplifying reactions. By linking cell‐based amplifiers in sequence, the resulting immune response is made highly sensitive to small changes in the environment. Thus, intercellular communication in the immune system can be viewed as a higher level analogue to the kinase cascades that amplify intracellular signalling mechanisms.
[The effect of hyperbaric oxygen therapy on treatment of late healed wounds after pharyngeal and laryngeal surgery]. (2011)

HBO therapy is an effective and powerful treatment for late healed postoperative wounds in pharyngeal and laryngeal carcinomas surgery.
What visual programming research contributes to universal access. (2001)

The results of our experiments do not substantiate in full the theory of the power of selective action of Streptococcus viridans. A few strains showed a remarkable constancy in location and type of lesion, but these strains were greatly in the minority. The location of the lesions in animals seemed to bear no relation to the origin of the organism or to the lesions produced by it in the patient from which the strain was obtained. Streptococcus viridans, regardless of site of origin in the patient, produced most lesions in the heart and joints.
APPLICATIONS OF ULTRASOUND TO MATERIALS CHEMISTRY (1999)

▪ Abstract The chemical effects of ultrasound derive primarily from acoustic cavitation. Bubble collapse in liquids results in an enormous concentration of energy from the conversion of the kinetic energy of the liquid motion into heating of the contents of the bubble. The high local temperatures and pressures, combined with extraordinarily rapid cooling, provide a unique means for driving chemical reactions under extreme conditions. A diverse set of applications of ultrasound to enhance chemical reactivity has been explored with important uses in synthetic materials chemistry. For example, the sonochemical decomposition of volatile organometallic precursors in low-volatility solvents produces nanostructured materials in various forms with high catalytic activities. Nanostructured metals, alloys, oxides, carbides and sulfides, nanometer colloids, and nanostructured supported catalysts can all be prepared by this general route. Another important application of sonochemistry in materials chemistry has been the preparation of biomaterials, most notably protein microspheres. Such microspheres have a wide range of biomedical applications, including their use in echo contrast agents for sonography, magnetic resonance imaging, contrast enhancement, and oxygen or drug delivery. Other applications include the modification of polymers and polymer surfaces.
Electron cyclotron resonance microwave discharges for etching and thin-film deposition (1989)

A recent, important development in low-pressure and low-temperature plasma processing is the microwave electron cyclotron resonance (ECR) discharge. Its lack of electrodes and its ability to create high densities of charged and excited species at low pressures (≲10−4 Torr) make it an attractive processing discharge in etching and thin-film deposition applications. This article reviews the basic physics of ECR discharges and reviews the associated microwave system and applicator technologies. Waveguide and cavity ECR applicators are compared and are described in detail. Several ECR plasma processing reactors are also described. Methods of processing large surfaces are outlined, and typical experimentally measured ECR discharge characteristics are presented.
Supercritical Carbon Dioxide Impregnation of Gold Nanoparticles Demonstrates a New Route for the Fabrication of Hybrid Silk Materials (2021)

How many nanoparticles can we load in a fiber? How much will leak? Underlying is the relatively new question of the "space available" in fibers for nanoparticle loading. Here, using supercritical carbon dioxide (scCO<sub>2</sub>) as a carrier fluid, we explored the impregnation in four Indian silks (Mulberry, Eri, Muga, and Tasar) with five standard sizes of gold nanoparticles (5, 20, 50, 100 and 150 nm in diameter). All silks could be permanently impregnated with nanoparticles up to 150 nm in size under scCO<sub>2</sub> impregnation. Accompanying structural changes indicated that the amorphous silk domains reorganized to accommodate the gold NPs. The mechanism was studied in detail in degummed Mulberry silk fibers (i.e., without the sericin coating) with the 5 nm nanoparticle. The combined effects of concentration, time of impregnation, scCO<sub>2</sub> pressure, and temperature showed that only a narrow set of conditions allowed for permanent impregnation without deterioration of the properties of the silk fibers.
Developing a kinematic understanding of chest compressions: the impact of depth and release time on blood flow during cardiopulmonary resuscitation (2015)

Deeper MCC improved several hemodynamic parameters. Chest compressions with a 300 ms release time generated less blood flow than chest compressions with faster release times. MCC release time is an important quantitative metric of MCC quality and, if optimized, could improve MCC generated blood flows and pressures.
Foreword for the Special Section on ESD Modeling, Characterization, and Design (2013)

As the complexity of ESD design keeps increasing with the availability of new technologies and the demand for new applications, so do the challenges associated with robust ESD design. These challenges manifest themselves in a multitude of perspectives, including ESDmodeling, characterization, and design. To address each of the aforementioned issues, we have selected three invited papers that are extensions of original works presented at the 2012 EOS/ESD Symposium. The three papers are briefly summarized.
Mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata (2009)

This study aimed to evaluate the mutagenic and antimutagenic potentials of Pueraria mirifica and Pueraria lobata by the Ames test preincubation method in the presence and absence of rat liver S9 mixture for metabolic activation in Salmonella typhimurium strains TA98 and TA100. The cytotoxicity of the two plant extracts to the two S. typhimurium indicator was evaluated. Both plant extracts at a final concentration of 2.5, 5, 10 or 20mg/plate exhibited only mild cytotoxic effects. At a final concentration of 2.5, 5, or 10mg/plate in the presence and absence of S9 mixture, both were negative in the mutagenic Ames test. Both plant extracts were positive in the antimutagenic Ames test towards either one or both of the tested mutagen: 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) and benzo(a)pyrene. Both the absence of mutagenic and the presence of antimutagenic activities of the two plant extracts were confirmed in rec-assays. Micronucleus test of both plant extracts exhibited no significant micronucleus formation in the tested rats. The overall tests confirmed the non-mutagenic but reasonably antimutagenic activities of the two plant extracts thus supporting their current prescribed as safe dietary supplements and cosmetics.
A Prospective, Randomized, Controlled Cervical Fusion Study Using Recombinant Human Bone Morphogenetic Protein-2 With the CORNERSTONE-SR™ Allograft Ring and the ATLANTIS™ Anterior Cervical Plate (2003)

This pilot study demonstrates the feasibility of using rhBMP-2 safely and effectively in the cervical spine.
Supplementary Tables S1-S4 from Prospective Associations of Hemoglobin A<sub>1c</sub> and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort (2023)

&lt;p&gt;Supplemental Table 1 - Association of self-reported T2DM at blood draw with risk of all-cancers combined and separately in CPS-II LifeLink participants; Supplemental Table 2 - Association BMI per 5 kg/m2 at blood draw with risk of all-cancers combined and separately in CPS-II LifeLink participants. Excludes those with BMI &lt;18.5 kg/m2; Supplementary Table 3 - Associations of c-peptide with risk of all cancers combined and for the specific cancers of interest by sex in the CPS-II LifeLink cohort; Supplementary Table 4 - Associations of HbA1c with risk of all cancers combined and for the specific cancers of interest by sex in the CPS-II LifeLink cohort.&lt;/p&gt;
Engineering and mechanistic studies of theArabidopsisFAE1 β‐ketoacyl‐CoA synthase, FAE1 KCS (2002)

The Arabidopsis FAE1 beta-ketoacyl-CoA synthase (FAE1 KCS) catalyzes the condensation of malonyl-CoA with long-chain acyl-CoAs. Sequence analysis of FAE1 KCS predicted that this condensing enzyme is anchored to a membrane by two adjacent N-terminal membrane-spanning domains. In order to characterize the FAE1 KCS and analyze its mechanism, FAE1 KCS and its mutants were engineered with a His6-tag at their N-terminus, and expressed in Saccharomyces cerevisiae. The membrane-bound enzyme was then solubilized and purified to near homogeneity on a metal affinity column. Wild-type recombinant FAE1 KCS was active with several acyl-CoA substrates, with highest activity towards saturated and monounsaturated C16 and C18. In the absence of an acyl-CoA substrate, FAE1 KCS was unable to carry out decarboxylation of [3-(14)C]malonyl-CoA, indicating that it requires binding of the acyl-CoA for decarboxylation activity. Site-directed mutagenesis was carried out on the FAE1 KCS to assess if this condensing enzyme was mechanistically related to the well characterized soluble condensing enzymes of fatty acid and flavonoid syntheses. A C223A mutant enzyme lacking the acylation site was unable to carry out decarboxylation of malonyl-CoA even when 18:1-CoA was present. Mutational analyses of the conserved Asn424 and His391 residues indicated the importance of these residues for FAE1-KCS activity. The results presented here provide the initial analysis of the reaction mechanism for a membrane-bound condensing enzyme from any source and provide evidence for a mechanism similar to the soluble condensing enzymes.
ChemInform Abstract: REDUCTION OF β‐KETO SULFOXIDES: A HIGHLY EFFICIENT ASYMMETRIC SYNTHESIS OF BOTH ENANTIOMERS OF ALLYLIC ALCOHOLS (1985)

Abstract Die durch Umsetzung des Sulfoxids (I) mit den Estern bzw. Imidazolen (II) dargestellten β‐Ketosulfoxide (III) werden mit hohem Enantiomerenüberschuß zu (IV) bzw. (V) reduziert.
Effect of UVM induction on mutation fixation at non‐pairing and mispairing DNA lesions (1996)

Mutation fixation at an ethenocytosine (epsilon C) residue borne on transfected M13 single-stranded DNA is significantly enhanced in response to pretreatment of Escherichia coli cells with UV, alkylating agents or hydrogen peroxide, a phenomenon that we have called UVM for UV modulation of mutagenesis. The UVM response does not require the E. coli SOS or adaptive responses, and is observed in cells defective for oxyR, an oxidative DNA damage-responsive regulatory gene. UVM may represent either a novel DNA-repair phenomenon, or an unrecognized feature of DNA replication in damaged cells that affects a specific class of non-coding DNA lesions. To explore the range of DNA lesions subject to the UVM effect, we have examined mutation fixation at 3,N4-ethenocytosine and 1,N6-ethenoadenine, as well as at O6-methylguanine (O6mG). M13 viral single-stranded DNA constructs bearing a single mutagenic lesion at a specific site were transfected into cells pretreated with UV or 1-methyl-3-nitro-1-nitroso-guanidine (MNNG). Survival of transfected viral DNA was measured as transfection efficiency, and mutagenesis at the lesion site was analysed by a quantitative multiplex sequence analysis technology. The results suggest that the UVM effect modulates mutagenesis at the two etheno lesions, but does not appear to significantly affect mutagenesis at O6mG. Because the modulation of mutagenesis is observed in cells incapable of the SOS response, these data are consistent with the notion that UVM may represent a previously unrecognized DNA damage-inducible response that affects the fidelity of DNA replication at certain mutagenic lesions in Escherichia coli.