gebhart/patrepeval huggingface dataset:
Digital apothecaries: a vision for making health care interventions accessible worldwide (2018)

Evidence-based psychological interventions are growing in number but are not within reach of many individuals who could benefit from them. The recent revolution in digital technologies now makes it possible to reach people around the globe with digital interventions in the form of web sites, mobile applications, wearable devices, and so on. Although a plethora of digital interventions are available online few are evidence-based and individuals have little guidance to decide among the multitude of options. We propose the development of "digital apothecaries," that is, online repositories of evidence-based digital interventions. As portals to effective interventions, digital apothecaries would be useful to individuals who could access evidence-based interventions directly, to health care providers, who could identify specific digital tools to suggest to or use with their patients, and to researchers, who could study a range of tools with large samples, enabling comparative tests and evaluation of moderators of effects. We present a taxonomy of types of in-person and digital interventions ranging from traditional therapy without the use of digital tools to totally automated self-help interventions. This taxonomy highlights the potential of blending digital tools into health care systems to expand their reach. Digital apothecaries would provide access to evidence-based digital interventions (both free and paid versions), provide data on effectiveness (including effectiveness for diverse populations), and encourage the development and testing of more such tools. Other issues discussed include: criteria for inclusion of interventions into digital apothecaries; how digital tools could enhance health care for diverse populations; and cautionary notes regarding potential negative unintended consequences of the adoption of digital interventions into the health care system. In particular, we warn about the potential misuse of evidence-based digital interventions to justify reducing access to live providers. Digital apothecaries bring with them the promise of reducing health disparities by reaching large numbers of individuals across the world who need health interventions but are not currently receiving them. The health care field is encouraged to mindfully develop this promise, while being alert not to cause inadvertent harm.
Telomeric RNAs as a novel player in telomeric integrity (2009)

Telomeres protect linear chromosome ends from being recognized and processed as double-strand breaks by DNA repair activities. This protective function of telomeres is essential for chromosome stability. Until recently, telomeres have been considered to be transcriptionally silent. This notion was overturned in a series of recent papers that describe the existence of telomeric repeat-containing RNAs (TERRAs) in vertebrates and yeast. Here, we summarize recent developments in this field of telomere research, in particular the possible mechanisms that control TERRA expression.
Bovine Papillomavirus Replicative Helicase E1 Is a Target of the Ubiquitin Ligase APC (2004)

The papillomavirus E1 replicative helicase is essential for replication and maintenance of extrachromosomal viral genomes in infected cells. We previously found that the bovine papillomavirus E1 protein is a substrate of the ubiquitin-dependent proteolytic pathway. Here we show that E1 is targeted for degradation by the anaphase-promoting complex (APC). Inhibition of APC activity by the specific inhibitor Emi1 or point mutations in the D-box and KEN-box motifs of E1 stabilize the protein and increase viral DNA replication in both a cell-free system and in living cells. These findings involve APC as the ubiquitin ligase that controls E1 levels to maintain a constant low copy number of the viral genome during latent infection.
Subclinical Myocardial Damage after Anthracycline Chemotherapy in Patients with Breast Cancer (2022)

Abstract Purpose: Data on the incidence, timing, and prediction of myocardial damage after anthracycline-based chemotherapy (AC) in patients with breast cancer are limited. We assessed myocardial damage in these patients following AC, using the high-sensitivity troponin I (TnI) assay. Methods: We prospectively assessed TnI levels in women with breast cancer (n=51) at baseline (before the first AC), 1 week, and 1, 2, 3, 6, 9,12, and 15 months after low-to-moderate doses of AC. Subclinical myocardial damage was diagnosed when TnI levels exceeded the 99th percentile (26 pg/mL). Echocardiograms were obtained at baseline and 3, 6, 9, 12, and 15 months post-AC. Results: Subclinical myocardial damage was detected in 43% of the patients: in 0%, 3.9%, 7.8%, 33%, 29%, 6.7%, 2.3%, and 2.3% of patients at 1 week and 1, 2, 3, 6, 9, 12, and 15 months after starting AC, respectively. From baseline to 1 week post-AC, median absolute change in TnI levels was 1.6 (interquartile range: 0.1–3.5) pg/mL. Absolute change in TnI levels ≥1.6 pg/mL at 1 week was associated with a higher peak TnI level during follow-up (p=0.042). Conclusions: Approximately half of the patients had subclinical myocardial damage, frequently observed at 3 or 6 months post-AC. TnI level changes at 1 week after the first AC may predict subsequent myocardial damage.
N.M.R. SPIN-ECHO SELF-DIFFUSION MEASUREMENTS ON FLUIDS UNDERGOING RESTRICTED DIFFUSION (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN.M.R. SPIN-ECHO SELF-DIFFUSION MEASUREMENTS ON FLUIDS UNDERGOING RESTRICTED DIFFUSIOND. E. WoessnerCite this: J. Phys. Chem. 1963, 67, 6, 1365–1367Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://pubs.acs.org/doi/10.1021/j100800a509https://doi.org/10.1021/j100800a509research-articleACS PublicationsRequest reuse permissionsArticle Views614Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Denjoy-Wolff theorem for compact holomorphic mappings in complex Banach spaces (2013)

domains in arbitrary complex Banach spaces.
Development and characterization of clay facial mask containing turmeric extract solid dispersion (2017)

The water solubility and permeability of curcumin in clay based facial mask could be improved using solid dispersion technique and suitable clay base composed of K, M, and Talc.
Tumor–lymphatic interactions in an activated stromal microenvironment (2006)

Metastasis to lymph nodes is a common feature of many human tumors and may facilitate dissemination to other parts of the body. Peritumoral lymphatics, which are located at the periphery of a primary tumor, appear to be anything but peripheral for metastasis, as recent studies have highlighted their critical role in disseminating tumor cells to local lymph nodes. The metastatic process, including lymphangiogenesis, is likely governed by a complex series of interactions among tumor cells, endothelial cells, and non-endothelial stromal components. Therefore, a detailed understanding of the biology of the tumor microenvironment, particularly as it pertains to peritumoral lymphatics near the tumor-stromal junction, may someday translate into clinical approaches that target metastasis at the invasive front.
Feasibility of Energy-Autonomous Wireless Microsensors for Biomedical Applications: Powering and Communication (2014)

In this review, biomedical-related wireless miniature devices such as implantable medical devices, neural prostheses, embedded neural systems, and body area network systems are investigated and categorized. The two main subsystems of such designs, the RF subsystem and the energy source subsystem, are studied in detail. Different application classes are considered separately, focusing on their specific data rate and size characteristics. Also, the energy consumption of state-of-the-art communication practices is compared to the energy that can be generated by current energy scavenging devices, highlighting gaps and opportunities. The RF subsystem is classified, and the suitable architecture for each category of applications is highlighted. Finally, a new figure of merit suitable for wireless biomedical applications is introduced to measure the performance of these devices and assist the designer in selecting the proper system for the required application. This figure of merit can effectively fill the gap of a much required method for comparing different techniques in simulation stage before a final design is chosen for implementation.
Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas (2011)

The source of new β-cells in adult human pancreas remains incompletely elucidated with recent studies on rodents providing evidence for neogenesis from progenitor cells in addition to self-replication. The aim of this study was to investigate the expression of pluripotency-associated stem cell markers in proliferative cultures derived from adult human pancreas. Human pancreatic tissue was obtained from deceased donors following ethical approval and relative consent. Islet-enriched fraction was separated from the retrieved organ by digestion and density gradient centrifugation. Dissociated cells were seeded in adherent culture forming proliferative 'islet survivor cells' (ISCs). These were characterised at fifth passage by RT-PCR, immunofluorescence staining, FACS, western blot and transfection studies with an OCT4 promoter-driven reporter. Nuclear expression of the pluripotency-associated stem cell marker complex OCT4/SOX2/NANOG was confirmed in ISCs. The phenotype constituted ∼8% of the overall population. OCT4 biosynthesis was confirmed by western blot and activation of an exogenous OCT4 promoter. Co-expression of pluripotency-associated markers has been confirmed in proliferative primary cells derived from adult human pancreas. Further studies are required to elucidate whether these cells possess functional stem cell characteristics and assess potential for differentiation into pancreatic cell lineages including new β-cells.
Method for recording ion-cyclotron-resonance mass spectra and mass spectrometer designed for carrying out the method (1989)

Methods and spectrometers for carrying out ion-cyclotron-resonance spectrometry are described in which a pulse sequence is employed which is described by P1-t1-P2-Tm-P3-t2, (P1, P2, and P3 are radio-frequency pulses, with P1 and P2 having the same frequency; t1 and Tm are time intervals between the pulses; and t2 is the observation time following the last pulse); the sequence is repeated several times while varying t1 to obtain a plurality of induction signals during t2, from which a 2-dimensional spectrum may be derived by transformation from the time to the frequency domain. The transformation may be accomplished by 2-dimensional Fourier transformation or by the method of max. entropy. [on SciFinder (R)]
Calanolides, the naturally occurring anti-HIV agents. (2000)

Both naturally occurring and semi-synthetic calanolide compounds are potent anti-human immunodeficiency virus (HIV) agents. In fresh human cells, they are highly effective inhibitors against low passage clinical virus strains, including those representative of the various HIV-1 clade strains (A through F), syncytium-inducing (SI) and non-syncytium-inducing (NSI) isolates, and T-tropic and monocyte-tropic isolates. These compounds also exhibit an enhanced antiviral activity against one of the most prevalent non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant viruses that is engendered by the Y181C amino acid change in reverse transcriptase (RT). Further enhancement of activity is observed with RTs that possess the Y181C change together with AZT-resistant mutations. Moreover, when challenged with viruses containing Y181C and K103N dual mutations, calanolide compounds remain active. These dual mutations are highly resistant to all approved NNRTIs (eg, delavirdine, nevirapine and efavirenz). In cell culture assays, calanolide compounds, especially (+)-calanolide A, select primarily resistant viruses possessing the T139I amino acid change. This mutation appears to be unique to calanolides since it remains susceptible to other NNRTIs. Synergistic effects are observed in both cultured cells and animal models when calanolides are used in combination with other anti-HIV agents. Enzymatic analyses indicate that calanolides inhibit HIV-1 RT through a mechanism that affects both the Km for normal substrate dTTP and the Vmax, resulting in a mixed-type inhibition, which is different from that of other known NNRTIs. Two possible binding modes/sites at the HIV-1 RT enzyme have been suggested for (+)-calanolide A. Taken together, the calanolide compounds represent a novel and distinct subgroup of the NNRTI family and inclusion of a calanolide in a combination therapy may be clinically beneficial. Of particular interest is the use of calanolide in the treatment of patients who have failed other NNRTI therapy and developed the Y181C mutation or the Y181C/K103N dual mutations. Currently, (+)-calanolide A, the most potent in the series of calanolide compounds, is undergoing clinical investigation for safety and efficacy in HIV-infected individuals.
ILDA safety certification for laser light show technicians (1992)

Most hazardous industrial operations have operator certification programs to ensure both competence and safe practice. This is particularly true when there is significant danger to the general public, such as with rigging or electrical distribution. While the various laser display companies have substantially different equipment designs, there exists a common ground in the safe use of this equipment. This should be of particular importance to these companies, as it is their employees who are at greatest risk. The International Laser Display Association is the ideal agency for administering a safety certification program. Such a programs, and the accompanying training course, will help to ensure a minimum knowledge base among operators in the field. Not only will it improve safety practices, but it will also help safety officials differentiate legitimate operators from renegades, and reduce the need for field inspections, licensing, and additional regulation.
High-speed DRAM interface (2002)

The data rate of the dynamic random access memory (DRAM) interface has been greatly increased to reduce the performance gap between the DRAM and the central processing unit (CPU). The data rate of double-data rate (DDR) synchronous DRAM (SDRAM) is now exceeding 266 Mb/s/pin while the packet-based RAMBUS DRAM is offering up to 1066 Mb/s/pin data rate. The difference in the data rate is mainly due to their different channel structures. These DRAM interface channels are basically multi-drop bus where a driver should drive multiple loads. The maximum data rate is determined by how the multiple loads are configured. The data rate of the DRAM interface channel has been greatly increased and is expected to exceed 2 Gb/s/pin in the near future. To achieve this goal, the physical interface such as the bus structure should be optimized to minimize the timing uncertainty. The I/O timing circuitry plays an important role in determining the maximum data rate. Thus, the, circuit design should also be focused on minimizing timing uncertainty.
Mechanism of electron transfer reaction of ternary nitrilotriacetatocobalt(II) complexes involving succinate and malonate as secondary ligands (2008)

Abstract The mechanism of oxidation of ternary complexes, [Co II (nta)(S)(H 2 O) 2 ] 3− and [Co II (nta)(M)(H 2 O)] 3− (nta = nitrilotriacetate acid, S = succinate dianion, and M = malonate dianion), by periodate in aqueous medium has been studied spectrophotometrically over the (20.0–40.0) ± 0.1°C range. The reaction is first order with respect to both [IO 4 − ] and the complex, and the rate decreases over the [H + ] range (2.69–56.20) × 10 −6 mol dm −3 in both cases. The experimental rate law is consistent with a mechanism in which both the hydroxy complexes [Co II (nta)(S)(H 2 O)(OH)] 4− and [Co II (nta)(M)(OH)] 4− are significantly more reactive than their conjugate acids. The value of the intramolecular electron transfer rate constant for the oxidation of the [Co II (nta)(S)(H 2 O) 2 ] 3− , k 1 (3.60 × 10 −3 s −1 ), is greater than the value of k 6 (1.54 × 10 −3 s −1 ) for the oxidation of [Co II (nta)(M)(H 2 O)] 3− at 30.0 ± 0.1°C and I = 0.20 mol dm −3 . The thermodynamic activation parameters have been calculated. It is assumed that electron transfer takes place via an inner‐sphere mechanism. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 40: 103–113, 2008
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function (2013)

Aberrant signaling by oncogenic mutant rat sarcoma (Ras) proteins occurs in ∼15% of all human tumors, yet direct inhibition of Ras by small molecules has remained elusive. Recently, several small-molecule ligands have been discovered that directly bind Ras and inhibit its function by interfering with exchange factor binding. However, it is unclear whether, or how, these ligands could lead to drugs that act against constitutively active oncogenic mutant Ras. Using a dynamics-based pocket identification scheme, ensemble docking, and innovative cell-based assays, here we show that andrographolide (AGP)--a bicyclic diterpenoid lactone isolated from Andrographis paniculata--and its benzylidene derivatives bind to transient pockets on Kirsten-Ras (K-Ras) and inhibit GDP-GTP exchange. As expected for inhibitors of exchange factor binding, AGP derivatives reduced GTP loading of wild-type K-Ras in response to acute EGF stimulation with a concomitant reduction in MAPK activation. Remarkably, however, prolonged treatment with AGP derivatives also reduced GTP loading of, and signal transmission by, oncogenic mutant K-RasG12V. In sum, the combined analysis of our computational and cell biology results show that AGP derivatives directly bind Ras, block GDP-GTP exchange, and inhibit both wild-type and oncogenic K-Ras signaling. Importantly, our findings not only show that nucleotide exchange factors are required for oncogenic Ras signaling but also demonstrate that inhibiting nucleotide exchange is a valid approach to abrogating the function of oncogenic mutant Ras.
SEPARATION, IDENTIFICATION AND CHARACTERISATION OF EXTRACTIVES FROM SUGARCANE (SACHARRUM OFFICINARUM) LEAF (2009)

The separation, identification and characterisation of the extractives from green and brown leaves of sugarcane plant (Sacharrum officinarum) are described. Green leaves were extracted by boiling in water, sonicating in a 1:1(v/v) methanol:water solution and 1:1(v/v) acetone:water solution and by the soxhlet technique. Dried leaves were extracted by sonication in a 1:1(v/v) methanol:water solution. Flavonoids and phenolic compounds in the green and dried leaf extracts were analysed, identified and characterised by use of Ultraviolet spectrophotometry and High Pressure Liquid Chromatography with photodiode array detection. The efficiency of the extraction methods were compared to previously reported values. The soxhlet technique gave the highest extraction of flavonoids and phenolic compounds.
Evolution of interface in pulsed electrode deposited titanium diboride on copper and steel (1999)

Pulsed electrode surfacing (PES) is a microwelding surfacing process for the successful deposition of ultrahard wear and erosion resistant ceramic coatings on metals. The present study investigates titanium diboride deposition on oxygen free high conductivity Cu. A thin and irregular coating with cracks was obtained on the Cu substrate, with the ceramic/metal interface distinct in TiB 2 deposited on Cu leading to decohesion at the interface. The present work has been compared with an earlier study on TiB 2 coatings deposited on 1018 steel using the PES technique. The difference in nature of the interfaces has been related to wettability, and the role of copper and iron as binders for TiB 2 ceramics has been addressed. Iron acts as an excellent binder for TiB 2 , providing a crack free coating and a strong interface, whereas Cu is a poor binder, leading to a weak ceramic/metal interface.
An integrated Bell-state analyzer for high fidelity entanglement between trapped ion quantum computers (2022)

The 53rd Annual Meeting of the APS Division of Atomic, Molecular and Optical Physics will take place from May 30 – June 3, 2022 in Orlando, Fl, USA. <a href="https://morressier.zoom.us/j/89880865272?pwd=SWxTRGhra1ZOSDBrSkhVZDBzVDR6UT09/">Virtual Presenter Help Desk</a>
Treatment of Sialorrhea With Glycopyrrolate (2000)

Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication. Arch Pediatr Adolesc Med. 2000;154:1214-1218.
Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors (2019)

Control of symptoms related to hormonal hypersecretion by functioning neuroendocrine tumors (NETs) is challenging. New therapeutic options are required. Since novel in vitro tumor models seem to better mimic the tumor in vivo conditions, we aimed to study the effect of somatostatin and dopamine receptor agonists (octreotide and cabergoline, respectively) and novel somatostatin-dopamine chimeric multi-receptor drugs (BIM-065, BIM-23A760) using 2D (monolayer) and 3D (spheroids) cultures. Dose-response studies in 2D and 3D human pancreatic NET cell cultures (BON-1 and QGP-1) were performed under serum-containing and serum-deprived conditions. Cell proliferation, somatostatin and dopamine receptor expression (SSTs and D2R), apoptosis, lactate dehydrogenase, as well as serotonin and chromogranin A (CgA) release were assessed. The following results were obtained. 3D cultures of BON-1/QGP-1 allowed better cell survival than 2D cultures in serum-deprived conditions. SSTs and D2R mRNA levels were higher in the 3D model vs 2D model. Octreotide/cabergoline/BIM-065/BIM-23A760 treatment did not affect cell growth or spheroid size. In BON-1 2D-cultures, only BIM-23A760 significantly inhibited CgA release -this effect being more pronounced in 3D cultures. In BON-1 2D cultures, cabergoline/BIM-065/BIM-23A760 treatment decreased serotonin release (maximal effect up to 40%), being this effect again more potent in 3D cultures (up to 67% inhibition; with BIM-23A760 having the most potent effects). In QGP-1, cabergoline/BIM-065 treatment decreased serotonin release only in the 3D model. In conclusion, cultures of NET 3D spheroids represent a promising method for evaluating cell proliferation and secretion in NET cell-line models. Compared to 2D models, 3D models grow relatively serum independent. In 3D model, SST-D2R multi-receptor targeting drugs inhibit CgA and serotonin secretion, but not NET cell growth.
Computer Aided Hydraulic Oil Formulations (2000)

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