gebhart/patrepeval huggingface dataset:
Arsenic trioxide sensitizes CD95/Fas‐induced apoptosis through ROS‐mediated upregulation of CD95/Fas by NF‐κB activation (2004)

CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of arsenic trioxide (As2O3) sensitized CD95/Fas-induced apoptosis in human cervical cancer cells, and the sensitizing effects resulted from As2O3-mediated increase in the expression of the CD95/Fas. N-acetyl-L-cysteine, a specific scavenger of reactive oxygen species, abrogated As2O3-induced upregulation of CD95/Fas and enhancement of CD95/Fas-mediated apoptosis. Furthermore, inhibition of NF-kappaB by transient transfection of IkappaBalpha supersurppessor blocked the increase of CD95/Fas expression following As2O2 treatment. Antisense oligonucleotide of CD95/Fas and ZB4, an antibody that blocks the binding of CD95/Fas ligand to CD95/Fas, reduced the amount of As2O3-sensitized CD95/Fas-induced apoptosis, demonstrating the specificity of CD95/Fas-binding ligands in the As2O3-sensitized CD95/Fas-induced apoptosis. These findings demonstrate that sensitization of human cervical cancer cells to CD95/Fas-mediated apoptosis by As2O3 can be partly due to induction of ROS and subsequent upregulation of CD95/Fas gene expression by NF-kappaB activation.
New Antipoverty Drugs, Vaccines, and Diagnostics: A Research Agenda for the US President's Global Health Initiative (GHI) (2011)

On May 5, 2009, the Obama Administration announced its intention to launch an ambitious United States governmental strategy for global health [1–3]. The US Global Health Initiative (GHI) proposes US$63 billion over 6 years (FY 2009–FY 2014), US$10.5 billion annually on average, approximately 70% of which would be spent on the US President’s Emergency Plan for AIDS Relief (PEPFAR) [1]. If appropriated each year by Congress, the GHI would represent a significant response to calls by the Institute of Medicine of the National Academies for the US government (USG) to invest US$15 billion annually on development assistance for global health by 2012 [3]. In its current form, most of GHI is devoted to direct implementation of existing treatments and preventive interventions for the ‘‘big three diseases,’’ i.e., HIV/ AIDS, malaria, and tuberculosis, especially the delivery of antiretroviral drugs and other prevention measures, antimalarial drugs and bednets, and direct observed therapy, respectively, as well as other critical interventions to improve maternal and child health and strengthen health systems [1,3]. There is also an unprecedented commitment to provide treatments for the neglected tropical diseases (NTDs), with US$65 million committed in FY2010 for rapid impact packages and related measures targeting the seven most common NTDs, which comprise the most prevalent infections affecting the world’s poor [4–8].
Parameter sensitivity analysis and optimization for a satellite‐based evapotranspiration model across multiple sites using Moderate Resolution Imaging Spectroradiometer and flux data (2016)

Abstract Global and regional estimates of daily evapotranspiration are essential to our understanding of the hydrologic cycle and climate change. In this study, we selected the radiation‐based Priestly‐Taylor Jet Propulsion Laboratory (PT‐JPL) model and assessed it at a daily time scale by using 44 flux towers. These towers distributed in a wide range of ecological systems: croplands, deciduous broadleaf forest, evergreen broadleaf forest, evergreen needleleaf forest, grasslands, mixed forests, savannas, and shrublands. A regional land surface evapotranspiration model with a relatively simple structure, the PT‐JPL model largely uses ecophysiologically‐based formulation and parameters to relate potential evapotranspiration to actual evapotranspiration. The results using the original model indicate that the model always overestimates evapotranspiration in arid regions. This likely results from the misrepresentation of water limitation and energy partition in the model. By analyzing physiological processes and determining the sensitive parameters, we identified a series of parameter sets that can increase model performance. The model with optimized parameters showed better performance ( R 2 = 0.2–0.87; Nash‐Sutcliffe efficiency (NSE) = 0.1–0.87) at each site than the original model ( R 2 = 0.19–0.87; NSE = −12.14–0.85). The results of the optimization indicated that the parameter β (water control of soil evaporation) was much lower in arid regions than in relatively humid regions. Furthermore, the optimized value of parameter m 1 (plant control of canopy transpiration) was mostly between 1 to 1.3, slightly lower than the original value. Also, the optimized parameter T opt correlated well to the actual environmental temperature at each site. We suggest that using optimized parameters with the PT‐JPL model could provide an efficient way to improve the model performance.
Quality of Transmission Estimator Enabling the Transparency Paradigm in Legacy IMDD Networks (2018)

Optical transmission based on IMDD modulation and dispersion-managed links is still of interest for the community because of its low-cost. Although the optical technologies deployed for this networking scenario are well-consolidated, operators are still requiring software-based orchestration capabilities. To this purpose, the line system and in general the network management software need to rely on a Quality-of-Transmission Estimator (QoT-E) enabling a quick evaluation of lightpath performance for the optical feasibility and network optimization. In this work, we propose a QoT-E considering the joint effect of SPM, XPM and FWM.
Calcium carbonate (CaCO3) nanoparticle filled polypropylene: Effect of particle surface treatment on mechanical, thermal, and morphological performance of composites (2011)

Abstract The present study was aimed to see the effect of surface treatment on nanocomposites with different fatty acids (stearic acid and oleic acid) having two different coupling agents (titanate and silane). Nanocomposites were prepared via melt mixing in Haake 90 twin screw extruder. The characterization of nanocomposites had been carried out using various advance analytical techniques such as dynamic mechanical analysis, thermogravimetric analysis, heat distortion temperature, melt flow index, and scanning electron microscopy. The strength and stiffness were also improved with the incorporation of maleic‐anhydride grafted ethylene propylene rubber in PP/Nano‐CaCO 3 nanocomposites. The tensile, flexural, and impact strength properties of PP/MA‐g‐EPR/treated‐CaCO 3 and untreated nanocomposites were determined. These studies revealed that stearic acid treated nanofiller filled composites had better properties than those of untreated and oleic acid treated nanofiller filled composites. The SEM studies demonstrated that the dispersion and distribution of Nano‐CaCO 3 (nCaCO 3 ) particles within the polypropylene matrix were dependent on the nature of surface treating agents. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
The Synthesis and Properties of γ-Aminoacetoacetic Acid (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Properties of γ-Aminoacetoacetic AcidJ. B. Neilands, A. Neuberger, and J. J. ScottCite this: J. Am. Chem. Soc. 1960, 82, 1, 214–217Publication Date (Print):January 1, 1960Publication History Published online1 May 2002Published inissue 1 January 1960https://pubs.acs.org/doi/10.1021/ja01486a048https://doi.org/10.1021/ja01486a048research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preparation of poly(butyl methacrylate)/?-Al2O3 nanocomposites via ultrasonic irradiation (2001)

A new technique (ultrasonic irradiation) has been employed to prepare poly(n-butyl methacrylate) PBMA/γ-Al2O3 nanocomposites, taking advantages of the multiple effects of ultrasonic irradiation, such as dispersion, pulverization and activation. When subjected to ultrasonic irradiation, n-butyl methacrylate (BMA) is polymerized to form poly(n-butyl methacrylate) (PBMA) latex without any chemical initiators, and the monomer conversion reaches 72.5% in 25 min. At an appropriate pH, surfactant bilayers are formed through electrostatic interactions between γ-Al2O3 nanoparticles and the anionic surfactant sodium dodecyl sulfate (SDS), which adsorb BMA. After ultrasonic induced polymerization of BMA in the presence of nanoparticles of γ-Al2O3, the γ-Al2O3 nanoparticles are encapsulated by PBMA shells formed. The influence of factors such as pH, surfactant concentration and the nanoparticle content is investigated. The FTIR spectra show that there are still polymers tightly adsorbed by nanoparticles even after extraction by acetone for 72 h. The difference observed in the XPS spectra of nanocomposite residues and the pure γ-Al2O3 nanoparticles may indicate some interactions between γ-Al2O3 nanoparticles and the PBMA matrix. Furthermore, the feasibility of SDS bilayer formation and encapsulating polymerization is proven by XPS characterization. © 2001 Society of Chemical Industry
Deep-sea search and recovery: with and without operating an underwater vehicle (2018)

Abstract. Deep-sea search and recovery mainly refers to the search, recovery, and salvage of objects with high value that are lost on the deep-sea bottom. Deep-sea search and recovery objects include aircraft black boxes, underwater vehicles, and other types of objects. The recovery and salvage of objects involves accurately obtaining their underwater positions. Depending on whether or not the salvage object carries an acoustic beacon, two methods are available: onboard acoustic signal search and near-bottom sweep search and search. Once the underwater position of a salvage object is known, it can be recovered and salvaged with a remotely operated underwater vehicle (ROV) and/or human-occupied vehicle (HOV). However, there are many difficulties with the practical application of existing deep-sea recovery systems that are based on the deep-sea operation of ROVs and HOVs. Based on the design idea and working mode of TV-grab in oceanography, this paper proposes a new type of deep-sea recovery system that does not rely on operating underwater vehicles and presents its recovery process. The new deep-sea recovery system combines underwater optical imaging, mechanical docking/grasping, acoustic imaging and positioning, and propeller operating to provide low-cost and rapid deep-sea recovery. Compared to the deep-sea recovery system with a ROV and/or HOV, the new deep-sea recovery system without an operating underwater vehicle described in this paper is proposed to be used, but not tested yet.
Frame-Frame Matching for Realtime Consistent Visual Mapping (2007)

Many successful indoor mapping techniques employ frame-to-frame matching of laser scans to produce detailed local maps, as well as closing large loops. In this paper, we propose a framework for applying the same techniques to visual imagery, matching visual frames with large numbers of point features. The relationship between frames is kept as a nonlinear measurement, and can be used to solve large loop closures quickly. Both monocular (bearing-only) and binocular vision can be used to generate matches. Other advantages of our system are that no special landmark initialization is required, and large loops can be solved very quickly.
A New Series of Natural Prostaglandins Identification of 1a,1b-dihomo-2,3-didehydro-PGE2in Ram Seminal Vesicles (1993)

Abstract A novel natural E-prostaglandin - 1a-1b-dihomo-2,3 didehydro-PGE2 (1) was isolated from ram seminal vesicles and its structure was elucidated by MS and NMR analysis.
Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. (1999)

We have previously reported the cloning of rat deoxyuridine triphosphate nucleotidohydrolase (dUTPase) cDNA and demonstrated that the full-length protein as well as the N-terminal 62-amino acid peptide interacts with peroxisome proliferator-activated receptor alpha (PPARalpha). We now report the cloning of mouse dUTPase cDNA and show that it contains a 162-amino acid open reading frame, encoding a protein with a predicted Mr of 17,400 and differs from rat cDNA, which contains additional 43 amino acids at the N-terminal end. Unlike rat dUTPase, mouse dUTPase failed to bind PPARalpha. An evaluation of 205 amino acid containing rat dUTPase cDNA revealed that the N-terminal 43 extra amino acid segment contains an LXXLL signature motif, considered necessary and sufficient for the binding of several cofactors with nuclear receptors, and its absence in murine dUTPase possibly accounts for the differential binding of these enzymes to PPARalpha. In situ hybridization and immunohistochemical studies revealed that, in the adult mouse, dUTPase is expressed at high levels in proliferating cells of colonic mucosa, and of germinal epithelium in testis. At 9.5-day mouse embryonic development, dUTPase expression is predominantly in developing neural epithelium, and hepatic primordium, and in later developmental stages (11.5-, 13.5-, and 15.5-day embryo), the expression began to be localized to the liver, kidney, gut epithelium, thymus, granular layer of the cerebellum, and olfactory epithelium. We also show that the murine dUTPase gene comprises 6 exons and the 5'-flanking region of -1479 to -27, which exhibited high promoter activity, contains a typical TATA box and multiple cis-elements such as Sp-1, AP2, AP3, AP4, Ker1, RREB, and CREB binding sites. These observations suggest the existence of variants of dUTPase, some of which may influence nuclear receptor function during development and differentiation, in addition to catalyzing the hydrolysis of dUTP to dUMP.
HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen. (1993)

H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by gamma-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a nonimmunogenic allelic form of HMT, differs from the common HMTa molecule by four amino acids, of which only two (residues 31 and 95) are located in the alpha 1 and alpha 2 domains that form the peptide-binding groove. Recognition of site-directed mutants by Mta-specific cytotoxic T lymphocytes was hardly affected by the substitution of Met for Val31 but was abolished by the substitution of Gln for Leu95, which is located in the beta-sheet floor of the peptide-binding groove. Thus a single amino acid difference is responsible for the immunological silence of HMTb.
Chirped-pulse and solitary mode-locked Yb:KLuW thin-disk laser oscillator (2009)

We present a mode-locked Yb:KLu(WO4)2 thin-disk laser oscillator delivering 25 W of average output power. The laser performance of chirped-pulse operation in the positive dispersion regime is compared with solitary operation.
Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter (2010)

The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor; however, the mechanistic basis for this is poorly understood. Here we demonstrate that downregulation of disabled homolog 2 (DAB2) gene expression via promoter methylation frequently occurs in human squamous cell carcinomas (SCCs) and acts as an independent predictor of metastasis and poor prognosis. Retrospective microarray analysis in an independent data set indicated that low levels of DAB2 and high levels of TGFB2 expression correlate with poor prognosis. Immunohistochemistry, reexpression, genetic knockout, and RNAi silencing studies demonstrated that downregulation of DAB2 expression modulated the TGF-beta/Smad pathway. Simultaneously, DAB2 downregulation abrogated TGF-beta tumor suppressor function, while enabling TGF-beta tumor-promoting activities. Downregulation of DAB2 blocked TGF-beta-mediated inhibition of cell proliferation and migration and enabled TGF-beta to promote cell motility, anchorage-independent growth, and tumor growth in vivo. Our data indicate that DAB2 acts as a tumor suppressor by dictating tumor cell TGF-beta responses, identify a biomarker for SCC progression, and suggest a means to stratify patients with advanced SCC who may benefit clinically from anti-TGF-beta therapies.
Insight into the Binding of Divalent Cations to Sepia Eumelanin from IR Absorption Spectroscopy (2006)

IR absorption spectroscopy is used to examine the binding of the divalent cations Mg(II), Ca(II), Zn(II) and Cu(II) to melanin granules isolated from the ink sacs of Sepia officinalis. The functional groups of the melanin granules interacting with the bound metal ions are deduced by examining the effect of metal concentration on transition frequencies associated with the COOH, NH and OH moieties of the pigment. The coordinating groups vary with metal ion and with concentration. For the experimental conditions used (initial solution pH of 4, ionic strength of 100 mM and a melanin concentration of 1 mg mL(-1)) Mg(II), Ca(II) and Zn(II) bind to carboxylate groups and Cu(II) binds predominantly to phenolic (catechol) groups However, at a concentration of 10 mM Cu(II) also shows evidence of binding to carboxylate and amine groups, reflecting a secondary binding site that becomes populated as the catechol sites are depleted.
Metal-metal interactions in one dimension. 1. Synthesis and structural and spectroscopic properties of dithioacetic acid derivatives of palladium(II) (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-metal interactions in one dimension. 1. Synthesis and structural and spectroscopic properties of dithioacetic acid derivatives of palladium(II)O. Piovesana, C. Bellitto, A. Flamini, and P. F. ZanazziCite this: Inorg. Chem. 1979, 18, 8, 2258–2265Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ic50198a042https://doi.org/10.1021/ic50198a042research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Simple method for the introduction of tetrafluoroethyl substituents into nitrogen heterocycles (2006)

A mild and convenient method for the preparation of 1,2,2,2-tetrafluoroethyl-substituted nitrogen heterocycles via a reaction of hexafluoropropene with azine and azole N-oxides is reported.
Photovoltaic nanocrystal scintillators hybridized on Si solar cells for enhanced conversion efficiency in UV (2008)

We propose and demonstrate semiconductor nanocrystal based photovoltaic scintillators integrated on solar cells to enhance photovoltaic device parameters including spectral responsivity, open circuit voltage, short circuit current, fill factor, and solar conversion efficiency in the ultraviolet. Hybridizing (CdSe)ZnS core-shell quantum dots of 2.4 nm in diameter on multi-crystalline Si solar cells for the first time, we show that the solar conversion efficiency is enhanced 2 folds under white light illumination similar to the solar spectrum. Such nanocrystal scintillators provide the ability to extend the photovoltaic activity towards UV.
Method for stabilizing low-level mixed wastes at room temperature (2023)

A method to stabilize solid and liquid waste at room temperature is provided comprising combining solid waste with a starter oxide to obtain a powder, contacting the powder with an acid solution to create a slurry, said acid solution containing the liquid waste, shaping the now-mixed slurry into a predetermined form, and allowing the now-formed slurry to set. The invention also provides for a method to encapsulate and stabilize waste containing cesium comprising combining the waste with Zr(OH).sub.4 to create a solid-phase mixture, mixing phosphoric acid with the solid-phase mixture to create a slurry, subjecting the slurry to pressure; and allowing the now pressurized slurry to set. Lastly, the invention provides for a method to stabilize liquid waste, comprising supplying a powder containing magnesium, sodium and phosphate in predetermined proportions, mixing said powder with the liquid waste, such as tritium, and allowing the resulting slurry to set.
Spontaneous brain activity as a source of ideal1/fnoise (2009)

We study the electroencephalogram (EEG) of 30 closed-eye awake subjects with a technique of analysis recently proposed to detect punctual events signaling rapid transitions between different metastable states. After single-EEG-channel event detection, we study global properties of events simultaneously occurring among two or more electrodes termed coincidences. We convert the coincidences into a diffusion process with three distinct rules that can yield the same mu only in the case where the coincidences are driven by a renewal process. We establish that the time interval between two consecutive renewal events driving the coincidences has a waiting-time distribution with inverse power-law index mu approximately 2 corresponding to ideal 1/f noise. We argue that this discovery, shared by all subjects of our study, supports the conviction that 1/f noise is an optimal communication channel for complex networks as in art or language and may therefore be the channel through which the brain influences complex processes and is influenced by them.