gebhart/patrepeval huggingface dataset:
Implementation of a Successful On-Call System in Clinical Chemistry (1997)

Successful practice of clinical pathology depends on a wide variety of laboratory, clinical, and managerial decisions. The skills needed to make these decisions can most effectively be learned by residents and fellows in pathology using a service-oriented on-call approach. We report our experience implementing an on-call system in the clinical chemistry laboratory at the University of Louisville Hospital (Ky). We detail the guidelines used to establish this system and the elements required for its successful implementation. The system emphasizes a laboratory-initiated approach to linking laboratory results to patient care. From inception of the program during late 1990 through 1995, the number of beeper calls (including clinician contacts) steadily increased and is currently 8 to 20 per week. The on-call system is active 24 hours per day, 7 days per week, thus representing activity on all three laboratory shifts. Types of responses were separated into administrative (12%), analytical (42%), clinical (63%), quality control or quality assurance (12%), and consultation (13%) categories. We also present 6 case reports as examples demonstrating multiple elements in these categories. In 23% of the calls, clinician contact was required and achieved by the fellow or resident on call for the laboratory. The on-call reports are documented and presented informally at weekly on-call report sessions. Emphasis is placed on learning and refinement of investigative skills needed to function as an effective laboratory director. Educational emphasis for the medical staff is in establishing awareness of the presence of the laboratory as an important interactive component of patient care. In addition, we found this program to be beneficial to the hospital and to the department of pathology in fulfilling its clinical service and teaching missions. Our experience may be helpful to other institutions establishing such a program.
Table S2 from Comparing Circulating Tumor Cell Counts with Dynamic Tumor Size Changes as Predictor of Overall Survival: A Quantitative Modeling Framework (2023)

&lt;p&gt;Î"OFV for the explored drop-out predictors in the first step&lt;/p&gt;
Unifying collaborative and content-based filtering (2004)

Collaborative and content-based filtering are two paradigms that have been applied in the context of recommender systems and user preference prediction. This paper proposes a novel, unified approach that systematically integrates all available training information such as past user-item ratings as well as attributes of items or users to learn a prediction function. The key ingredient of our method is the design of a suitable kernel or similarity function between user-item pairs that allows simultaneous generalization across the user and item dimensions. We propose an on-line algorithm (JRank) that generalizes perceptron learning. Experimental results on the EachMovie data set show significant improvements over standard approaches.
Stable p–i–n FAPbBr3 Devices with Improved Efficiency Using Sputtered ZnO as Electron Transport Layer (2017)

Radio‐frequency magnetron sputtering is demonstrated as an effective tool to deposit highly crystalline thin zinc oxide (ZnO) layer directly on perovskite absorber as an electron transport layer (ETL). As an absorber, formamidinium lead tribromide (FAPbBr 3 ) is fabricated through a modified single‐step solution process using hydrogen bromide (HBr) as an additive resulting in complete surface coverage and highly crystalline material. A planar p–i–n device architecture with spin‐coated poly‐(3,4‐ethylenedioxythiophene):poly‐styrenesulfonic acid (PEDOT:PSS) as hole transport material (HTM) and sputtered ZnO as ETL results in a short circuit current density of 9.5 mA cm −2 and an open circuit potential of 1.19 V. Numerical simulations are performed to validate the underlying loss mechanisms. The use of phenyl C 60 butyric acid methyl ester (PCBM) interface layer between FAPbBr 3 and sputter‐coated ZnO offers shielding from potential plasma‐related interface damage. The modified interface results in a better device efficiency of 8.3% with an open circuit potential of 1.35 V. Such devices offer better stability under continuous illumination under ambient conditions in comparison with the conventional organic ETL (PCBM)‐based devices.
NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity (2013)

Whereas neutrophil elastase, cathepsin G, and proteinase 3 have been known as granule-associated serine proteases of neutrophils for decades, a fourth member, called neutrophil serine protease 4 (NSP4), was just recently described and provisionally characterized. In this study, we identified NSP4 as a novel azurophil granule protein of neutrophils by Western blot analyses of subcellular fractions as well as by RT-PCR analyses of neutrophil precursors from human bone marrow. The highest mRNA levels were observed in myeloblasts and promyelocytes, similar to myeloperoxidase, a marker of azurophil granules. To determine the extended sequence specificity of recombinant NSP4, we used an iterative fluorescence resonance energy transfer-based optimization strategy. In total, 142 different peptide substrates with arginine in P1 and variations at the P1', P2', P3, P4, and P2 positions were tested. This enabled us to construct an α1-proteinase inhibitor variant (Ile-Lys-Pro-Arg-/-Ser-Ile-Pro) with high specificity for NSP4. This tailor-made serpin was shown to form covalent complexes with all NSP4 of neutrophil lysates and supernatants of activated neutrophils, indicating that NSP4 is fully processed and stored as an already activated enzyme in azurophil granules. Moreover, cathepsin C was identified as the activator of NSP4 in vivo, as cathepsin C deficiency resulted in a complete absence of NSP4 in a Papillon-Lefèvre patient. Our in-depth analysis of NSP4 establishes this arginine-specific protease as a genuine member of preactivated serine proteases stored in azurophil granules of human neutrophils.
[Relaxant effects of protopine on smooth muscles]. (1991)

The relaxant effects of protopine (Pro) on smooth muscles were studied by recording isotonic contraction and radioimmunoassay. Pro relaxed the contraction of rabbit thoracic aorta, mesenteric artery, portal vein and guinea pig ileum and taenia colon induced by high K+ (70 mmol.L-1). Pro also inhibited the contraction of rabbit thoracic aorta, mesenteric artery, portal vein induced by NE (0.3 mumol.L-1) and guinea pig taenia colon induced by BaCl2 (1 mmol.L-1). Pro inhibited the intracellular Ca2+ release, but did not inhibit Ca2+ influx induced by NE. These results suggested that the smooth muscle relaxant mechanism of action of Pro may be the inhibition of intracellular Ca2+ release.
Polymer-Modified Opal Nanopores (2006)

The surface of nanopores in opal films, assembled from 205 nm silica spheres, was modified with poly(acrylamide) brushes using surface-initiated atom transfer radical polymerization. The colloidal crystal lattice remained unperturbed by the polymerization. The polymer brush thickness was controlled by polymerization time and was monitored by measuring the flux of redox species across the opal film using cyclic voltammetry. The nanopore size and polymer brush thickness were calculated on the basis of the limiting current change. Polymer brush thickness increased over the course of 26 h of polymerization in a logarithmic manner from 1.3 to 8.5 nm, leading to nanopores as small as 7.5 nm.
Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR- and LC-MS-Based Metabolomics Approach (2018)

The official standard for quality control of honey is currently based on physicochemical properties. However, this method is time-consuming, cost intensive, and does not lead to information on the originality of honey. This study aims to classify raw stingless bee honeys by bee species origins as a potential classifier using the NMR-LCMS-based metabolomics approach. Raw stingless bee honeys were analysed and classified by bee species origins using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and an ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-QTOF MS) in combination with chemometrics tools. The honey samples were able to be classified into three different groups based on the bee species origins of <i>Heterotrigona itama</i>, <i>Geniotrigona thoracica</i>, and <i>Tetrigona apicalis</i>. d-Fructofuranose (<i>H. itama</i> honey), β-d-Glucose, d-Xylose, α-d-Glucose (<i>G. thoracica</i> honey), and l-Lactic acid, Acetic acid, l-Alanine (<i>T. apicalis</i> honey) ident d-Fructofuranose identified via ¹H-NMR data and the diagnostic ions of UHPLC-QTOF MS were characterized as the discriminant metabolites or putative chemical markers. It could be suggested that the quality of honey in terms of originality and purity can be rapidly determined using the classification technique by bee species origins via the ¹H-NMR- and UHPLC-QTOF MS-based metabolomics approach.
A Group Intervention Model for Speech and Communication Skills in Patients With Parkinson's Disease (2005)

Various speech and voice disorders affect 70% to 85% of individuals with Parkinson's disease (PD). Speech treatment is generally conducted on an individual basis, with family member involvement. Clinical experience indicates that many patients do not practice treatments at home or apply the learned techniques in everyday situations. An eight-session, task-oriented group intervention with PD patients who also had learned speech techniques individually prior to this program is described. Preliminary observations using subjective and objective measures indicate improvement in voice characteristics, self-perception of speech intelligibility, communication skills, and application of these skills in everyday communication situations.
LOCL-08 SAFETY AND FEASIBILITY OF RHENIUM-186 NANOLIPOSOME (186RNL) IN RECURRENT GLIOMA: THE RESPECT™ PHASE 1 TRIAL (2022)

Abstract BACKGROUND Liposomal rhenium-186 (186RNL) is a potent source of electrons with short path length, low dose rate, high radiation density and gamma emission. Preclinically, 186RNL via convection enhanced delivery (CED) achieves very high doses of targeted radiation and a wide therapeutic index. We report the updated results of ReSPECT, the first in man, dose escalation phase 1 trial of 186RNL in recurrent glioma. METHODS Following computer assisted treatment planning and placement of intracranial catheter(s), we performed a single administration of 186RNL by CED. Whole body planar and SPECT/CT imaging was obtained on days 1-8 following treatment for dosimetry and distribution. Patients were followed for safety, progression and survival. RESULTS Twenty-one patients across 7 cohorts received 1.0-22.3mCi in a tumor volume of 0.6-8.80mL. Mean tumor volume was 8.3mL (0.9-22.8mL). Patients had a mean of 1.7 recurrences, 5 with prior bevacizumab. 19 (91%) were grade 4 gliomas, and 100% were after cohort 4. We used a CED rate of 5-20µl/min per catheter, with 1-4 catheters per patient. Tumor mean absorbed radiation dose was 255Gy (8.9-740Gy) while exposure outside the brain was negligible. The mean percentage tumor in the treated volume (Tu/Tv) was 60.3% (19.8%-100%). Thus far, we have observed no dose limiting toxicities, one grade 3 treatment related adverse event (AEs), and the majority of AEs were mild in intensity. The incidence and severity of AEs did not correlate with increasing dose. Mean Tu/Tv in patients not receiving prior bevacizumab was 75% vs. 48% in those that had. Thus far, overall survival (OS) in 16 bevacizumab naïve patient is 49 weeks with 7 patients still alive and a positive correlation of OS to Tu/Tv. CONCLUSIONS 186RNL achieves high absorbed doses without significant toxicity with favorable overall survival. Updated delivery feasibility, safety and overall survival will be presented.
Surface plasmons in metallic nanoparticles: fundamentals and applications (2011)

Abstract\nThe excitation of surface plasmons in metallic nanoparticles induces optical properties hardly achievable in other optical materials, yielding a wide range of applications in many fields. This review presents an overview of surface plasmons in metallic nanoparticles. The concept of surface plasmons in nanoparticles is qualitatively described using a comparison with simple linear oscillators. The mathematical models to carry on calculations on surface plasmons are presented as well as the most common approximations. The different parameters governing the features of surface plasmons and their effect on the optical properties of the materials are reviewed. Finally, applications of surface plasmons in different fields as biomedicine, energy, environment protection and information technology are revised.
Probabilistic boosting-tree: learning discriminative models for classification, recognition, and clustering (2005)

In this paper, a new learning framework - probabilistic boosting-tree (PBT), is proposed for learning two-class and multi-class discriminative models. In the learning stage, the probabilistic boosting-tree automatically constructs a tree in which each node combines a number of weak classifiers (evidence, knowledge,) into a strong classifier (a conditional posterior probability). It approaches the target posterior distribution by data augmentation (tree expansion) through a divide-and-conquer strategy. In the testing stage, the conditional probability is computed at each tree node based on the learned classifier, which guides the probability propagation in its sub-trees. The top node of the tree therefore outputs the overall posterior probability by integrating the probabilities gathered from its sub-trees. Also, clustering is naturally embedded in the learning phase and each sub-tree represents a cluster of certain level. The proposed framework is very general and it has interesting connections to a number of existing methods such as the A* algorithm, decision tree algorithms, generative models, and cascade approaches. In this paper, we show the applications of PBT for classification, detection, and object recognition. We have also applied the framework in segmentation
Geometric Modeling and Manufacturing of a Human Left Ventricle for Hemodynamic Experimentation (2013)

I. Acosta, F. Medina, and R. Wicker, 'Geometric Modeling and Manufacturing of a Human Left Ventricle for Hemodynamic Experimentation,' Society of Hispanic Professional Engineers National Technical and Career Conference (NTCC), Student Technical Paper Competition, Dallas, Texas, January 5-8, 25.
The Neurotrophic Factor Artemin Promotes Pancreatic Cancer Invasion (2006)

Artemin expression was not associated with pain in PDAC. However by increasing cancer cell invasion, Artemin seems to influence neural invasion and thereby contribute to cancer cell spreading along pancreatic nerves.
ChemInform Abstract: Novel Diterpenoids from the Toadstools Tricholoma aurantium and T. fracticum (Agaricales). (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The LED driver compatible with electronic ballasts by variable switched capacitor (2015)

An LED driver compatible with most electronic ballasts commercially used now is newly proposed, which adopts a variable switched capacitor by controlling switching duty cycle for the LED power regulation. The resonant frequency of the LC resonant tank of electronic ballasts can be appropriately controlled, which makes the proposed LED driver be versatile for electronic ballasts for various switching frequencies. In this way, the fluorescent lamp can be replaced with an LED lamp, where the electronic ballast in the lighting infrastructure remains unchanged. The zero voltage switching is applied for the variable switched capacitor in the electronic ballast, operating at the frequency of 30 ~ 60 kHz. Neither an inductor nor a transformer is introduced in the proposed LED driver, which leads to compact size and high efficiency. Furthermore, no electrolytic capacitor is used, which is beneficial for the long lifetime of LED drivers. A prototype LED driver of 16 W was implemented and verified for the three types of electronic ballasts that are most popular in markets. The LED power was well regulated for a wide range of the source voltage variation of 180 ~ 270 V, and the power efficiencies of the proposed LED driver were 95.8%, 96.1%, and 94.1% for the instant start, rapid start, and programmed start types of the electronic ballasts, respectively.
ASSESSMENT OF MIXED LYMPHOCYTE REACTIVITY IN HUMAN BONE MARROW CELL CULTURES (1985)

The use of monoclonal anti-T-cell antibodies has been proposed as a means of eliminating T cells from bone marrow inocula, and thereby avoiding graft-versus-host reactions following transplantation. Since the mixed lymphocyte reaction (MLR) provides a measurement of alloreactive mature T cells, we have attempted to apply this assay to bone marrow populations before and after treatment with anti-T-cell antibodies and complement. However, initial studies showed MLR to be very difficult to measure using bone marrow as a responder cell population, and a systematic analysis of the reasons for this difficulty was therefore carried out. The first major problem in performance of standard one-way MLRs using bone marrow responder cells was found to be due to the presence of numerous non-T marrow cells that maintained high levels of background proliferation. Proliferation of these populations was found to be variable during MLR culture, leading to aberrant results. This problem was overcome by removing the rapidly proliferating population of marrow cells either by density centrifugation or by susceptibility to cryopreservation and thawing. A second problem causing variability even after removal of these proliferating cells was found to be due to additional non-T cells in the marrow that responded to soluble mediators produced by peripheral blood lymphocyte stimulator cells during an MLR. Such non-T-cell stimulation was not eliminated by removal of bone marrow T cells, obscuring the results of T cell depletion of the marrow. This problem was overcome by the use of HLA-defined B cell lines as stimulators. A mixture of such lines provided a reliable stimulator source that did not produce soluble mediators capable of stimulating additional marrow cells. These refinements of MLR conditions permit a reproducible and reliable assay of bone marrow MLR, and provide a means for assessment of elimination of such alloreactive cells by monoclonal antibodies and complement.
Evolution of space charge measurements: new approaches to physical problems (2003)

The author has shown that although space charge determination techniques are now well established, many new directions of research should bring information on the behaviour, the ageing and the electrical evolution of insulators. Real time measurements of space charge distributions at high repetition rate will permit study of the dynamics of charges under AC or rapidly varying electric stress. Three dimensional mapping of the charge or dipole distributions will help understanding the role of space charge in electrical ageing and breakdown, or the nonhomogeneous polarisation of dielectrics. Finally, by combining space charge measurement with complementary techniques, it will be possible to reach new types of information. The pressure wave propagation method, pulsed electro-acoustic method and thermal step method are discussed.
Effects of Prostaglandin F2 on the Mobilization of Cytosolic Free Calcium in Vascular Smooth Muscle Cells and on the Tension of Aortic Strips from Rats (1990)

The possible mechanism of action of prostaglandin F2 alpha on vascular smooth muscle was investigated. Prostaglandin F2 alpha induced sustained tonic vasoconstriction of rat aortic strips, accompanied by rapid increase in the cytosolic free Ca2+ concentration [( Ca2+]i) in the vascular smooth muscle cells. Prostaglandin F2 alpha also evoked rapid increase in production of inositol 1,4,5,-trisphosphate (Ins-P3). Moreover, it increased release of Ca2+ from nonmitochondrial pools in digitonin-permeabilized vascular smooth muscle cells, although this effect was much weaker than that of Ins-P3. These results suggest that the sustained action of prostaglandin F2 alpha may involve not only a rise in [Ca2+]i mediated by Ins-P3, but also a direct stimulation of Ca2+ from intracellular stores.
A 0.026mm2 capacitance-to-digital converter for biotelemetry applications using a charge redistribution technique (2007)

This paper proposes a direct capacitance-to-digital converter (CDC) for biotelemetry applications. The proposed circuit is based on a charge redistribution technique using a capacitive sensor and a ranging capacitor array. The circuit does not require accurate reference voltages, so it is robust for fluctuation of supply voltage. Output-code range can be dynamically zoomed in arbitrary capacitance range of sensor output by using the ranging capacitor array. An 8-bit converter with an active area of 0.026 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consuming 0.9 nJ per sample, is demonstrated. The proposed circuit maintains its performance even in the condition of 28% fluctuations in supply voltage. Measurement results of the readout circuit are also demonstrated, which shows that the proposed circuit can work well in the presence of large parasitic capacitances.
Aplicação de Estratégias de Ensino na Abordagem do Conteúdo de Eletroquímica (2012)

O ensino de ciencias exige extrema medida de abstracao e sua interacao com o meio cientifico da-se de forma gradual. Objetivou-se proporcionar estimulo ao estudo e compreensao do conteudo de eletroquimica focando a utilizacao de discussoes de textos, recursos audio visuais e experimentacao, buscando demonstrar que as aulas dinamizadas sao mais eficientes e mais dinâmicas que as aulas ditas tradicionais. Esta proposta de ensino apresentou uma metodologia atraente e eficaz, proporcionando o interesse e motivacao nos discentes, harmonizando tanto o aluno quanto o professor a alcancar os objetivos de ambas as partes, evitando a exaustao e monotonia que conduzem a um baixo desempenho. Concluiu-se que os discentes participantes deste projeto obtiveram excelente desempenho na I Mostra Cientifica organizada na escola participante, demonstrando empenho, dedicacao e conhecimento do conteudo, alem de estimular e despertar a curiosidade dos estudantes participantes do evento motivando-os a participarem do projeto.