gebhart/patrepeval huggingface dataset:
Abstract 20: Patient Characteristics and Outcomes among Early-Arriving Acute Stroke Patients for Whom Alteplase Was Dispensed but Not Administered (2015)

Introduction: Best practice recommendations such as the AHA Target Stroke campaign suggest that IV tPA be dispensed as early as possible prior to final clinical decision when evaluating stroke patients at high likelihood of tPA eligibility. This practice may reduce door to needle times. We sought to determine the patient characteristics, outcomes and reasons for non-treatment among this selected group of individuals presenting to our stroke service. Methods: During the period of April 2007 till June 2014, 4170 patients presented to our hospital with acute Ischemic stroke, and 1152/4180 (28%) presented within 4 hours of last seen well (LKW). Using our hospital’s GWTG database and pharmacy logs, we identified all tPA treated cases as well as those in whom tPA was dispensed but not given. Categorical variables were compared using chi- square test and continuous variables were compared using Student t-test and Wilcoxon rank sum test. Results: Of 382 patients for whom tPA was dispensed, 239 (62.6%) ultimately received tPA. Compared to tPA treated patients, the 143 untreated patients in this cohort were more likely to have a history of previous stroke, present with weakness or language disturbance, and had a lower median NIHSS (Table). Untreated patients were more likely to be transferred from another hospital than to present directly from the scene, had a shorter median time from ED arrival to tPA dispensed, were less likely to undergo intra-arterial thrombolysis but had similar rates of home discharge and mortality. The most common reasons for non-treatment were mild symptoms (28%), rapid improvement (15%) and arriving after “drip and ship” (8%). In multivariate analysis, only lower NIHSS [aOR 0.93 per point (0.90, 0.97), p&lt;0.001] and arrival via emergency medical services from scene [aOR 0.40 (0.24, 0.66), p &lt;0.001] were independently associated with non-treatment. Conclusion: Delays in tPA initiation are common, and reduce health outcomes after thrombolysis. In our study, early dispensing of tPA prior to the final eligibility assessment produced an overall rate of tPA treatment of &gt;60%. This conversion rate suggests that early tPA dispensing in high likelihood candidates is appropriate and supports the use of this strategy. Reasons for non-treatment were similar to those in unselected patients.
The development of a scoring scheme for content in transactional writing: Some indicators of audience awareness1 (1995)

Abstract Much importance is given to ‘audience awareness’ in writing research and pedagogy, but there have been few attempts at measuring it. In a study investigating the effects of using the mother‐tongue in the oral preparation for classroom writing in a second language, pupils were asked to explain how to play a game. In the scoring of the writing scripts at the level of content, it soon became clear that whether and how some information should be included was partly dependent on the writer's judgement of the reader. This paper starts by showing how our initial scoring scheme proved inadequate, and describes and explains how we gradually developed a more robust scheme. We present our final scheme, which attempts to take some account of the notion of audience awareness. In the context of this particular writing task, such awareness is seen in terms of whether the writer introduces certain details as new or assumed known information, and how far the writer relies on the reader's pragmatic inference. Finally, we pose some remaining questions for future work in this field.
Mechanistic insights into the enhancement or inhibition of phase separation by polyubiquitin chains of different lengths or linkages (2021)

Summary Ubiquitin-binding shuttle UBQLN2 mediates crosstalk between proteasomal degradation and autophagy, likely via interactions with K48- and K63-linked polyubiquitin chains, respectively. UBQLN2 is recruited to stress granules in cells and undergoes liquid-liquid phase separation (LLPS) in vitro . However, interactions with ubiquitin or multivalent K48-linked chains eliminate LLPS. Here, we found that, although some polyubiquitin chain types (K11-Ub4 and K48-Ub4) did generally inhibit UBQLN2 LLPS, others (K63-Ub4, M1-Ub4 and a designed tetrameric ubiquitin construct) significantly enhanced LLPS. Using nuclear magnetic resonance (NMR) spectroscopy and complementary biophysical techniques, we demonstrated that these opposing effects stem from differences in chain conformations, but not in affinities between chains and UBQLN2. Chains with extended conformations and increased accessibility to the ubiquitin binding surface significantly promoted UBQLN2 LLPS by enabling a switch between homotypically to partially heterotypically-driven phase separation. Our study provides mechanistic insights into how the structural and conformational properties of polyubiquitin chains contribute to heterotypic phase separation with ubiquitin-binding shuttles and adaptors. Highlights Ubiquitin or short polyubiquitin chains bind to phase separation-driving stickers on UBQLN2 and inhibit its phase separation whereas longer chains provide the multivalency needed to enhance UBQLN2 phase separation. Phase separation of UBQLN2 is promoted over a wide range of Ub:UBQLN2 ratios in the presence of extended M1- and K63-linked Ub4 chains, but not compact K11- and K48-linked Ub4 chains. Chain conformation and accessibility of the Ub interacting surface is a driving factor of UBQLN2/polyUb co-phase separation. UBQLN2 condensates assemble during in vitro enzymatic assembly of K63-linked polyUb chains as free ubiquitin is reduced.
Potential Retroviruses in Plants: Tat1 Is Related to a Group of Arabidopsis thaliana Ty3/gypsy Retrotransposons That Encode Envelope-Like Proteins (1998)

Tat1 was originally identified as an insertion near the Arabidopsis thaliana SAM1 gene. We provide evidence that Tat1 is a retrotransposon and that previously described insertions are solo long terminal repeats (LTRs) left behind after the deletion of coding regions of full-length elements. Three Tat1 insertions were characterized that have retrotransposon features, including a primer binding site complementary to an A. thaliana asparagine tRNA and an open reading frame (ORF) with approximately 44% amino acid sequence similarity to the gag protein of the Zea mays retrotransposon Zeon-1. Tat1 elements have large, polymorphic 3' noncoding regions that may contain transduced DNA sequences; a 477-base insertion in the 3' noncoding region of the Tat1-3 element contains part of a related retrotransposon and sequences similar to the nontranslated leader sequence of AT-P5C1, a gene for pyrroline-5-carboxylate reductase. Analysis of DNA sequences generated by the A. thaliana genome project identified 10 families of Ty3/gypsy retrotransposons, which share up to 51 and 62% amino-acid similarity to the ORFs of Tat1 and the A. thaliana Athila element, respectively. Phylogenetic analyses resolved the plant Ty3/gypsy elements into two lineages, one of which includes homologs of Tat1 and Athila. Four families of A. thaliana elements within the Tat/Athila lineage encode a conserved ORF after integrase at a position occupied by the envelope gene in retroviruses and in some insect Ty3/gypsy retrotransposons. Like retroviral envelope genes, this ORF encodes a transmembrane domain and, in some insertions, a putative secretory signal sequence. This suggests that Tat/Athila retrotransposons may produce enveloped virions and may be infectious.
Identification of Proinflammatory Flagellin Proteins in Supernatants of Vibrio cholerae O1 by Proteomics Analysis (2006)

The genome of Vibrio cholerae contains five flagellin genes that encode proteins (FlaA-E) of 39-41 kDa with 61-82% identity among them. Although the existing live oral attenuated vaccine strains against cholera are protective in humans, there is an intrinsic residual cytotoxic and inflammatory component associated with these candidate vaccine strains. Bacterial flagellins are known to be potent inducers of proinflammatory molecules via activation of Toll-like receptor 5. Here we found that purified flagella from wild type V. cholerae 395 induced significant release of interleukin (IL)-8 from cultured HT-29 human colonic epithelial cells. Furthermore we found that filtered supernatants of KKV90, a DeltaflaA isogenic strain unable to produce flagella, were still able to activate production of IL-8 albeit to significantly lower levels than the wild type, suggesting that other activators of proinflammatory molecules were still present in these supernatants. A comparative proteomics analysis of secreted proteins of V. cholerae 395 and KKV90 identified additional proteins with potential to induce IL-8 release in HT-29 cells. Secreted proteins in the range of 30-45 kDa identified by two-dimensional electrophoresis and mass spectrometry revealed the presence of two additional flagellins, FlaC and FlaD, that appeared to be secreted 3- and 6-fold more, respectively, in the mutant compared with the wild type. Double isogenic mutants flaAC and flaAD were unable to trigger IL-8 release from HT-29 cells. In sum, we have shown that purified flagella and secreted flagellin proteins (FlaC and FlaD) are inducers of IL-8 release from epithelial cells via Toll-like receptor 5. This observation may explain, in part, the observed reactogenicity of cholera vaccine strains in humans.
Complete Genome Sequence of Staphylococcus aureus Strain JKD6008, an ST239 Clone of Methicillin-Resistant Staphylococcus aureus with Intermediate-Level Vancomycin Resistance (2010)

We report here the complete 2.92-Mb genome sequence of a clinical isolate of methicillin-resistant Staphylococcus aureus subsp. aureus that demonstrates intermediate-level vancomycin resistance. The strain, named JKD6008, belongs to multilocus sequence type 239 and was isolated from the bloodstream of a patient in New Zealand in 2003.
Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway (2022)

Our data indicated that the cytoplasmic IL1R1/CD121a transduced IL1β signal in synMSCs. And the growth-promoting effect of IL1β can be separated from its inflammatory cytokine-inducing function in synMSCs.
Ultrafast all-optical switching using near-infrared inter-subband transition in an InGaAs/AlAs/AlAsSb/InP quantum well structure (2003)

Picosecond and subpicosecond all-optical switching using near-infrared intersubband transitions was demonstrated in an InGaAs/AlAs/AlAsSb quantum well structure. For a multiple quantum well structure, strong absorption at wavelengths shorter than 1.7 /spl mu/m was obtained. An inter-subband-pump and inter-band-probe measurement was performed on this material system using a femtosecond optical parametric amplifier system and white-light generation. Inter- and intra-subband relaxation was observed by measuring the time-wavelength resolved interband absorption induced by intersubband excitation. The present results demonstrate its applicability for ultrafast, highly efficient, all-optical modulators and switches.
On Feasibility of Interference Alignment in MIMO Interference Networks (2010)

We explore the feasibility of interference alignment in signal vector space-based only on beamforming-for <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> -user MIMO interference channels. Our main contribution is to relate the feasibility issue to the problem of determining the solvability of a multivariate polynomial system which is considered extensively in algebraic geometry. It is well known, e.g., from Bezout's theorem, that generic polynomial systems are solvable if and only if the number of equations does not exceed the number of variables. Following this intuition, we classify signal space interference alignment problems as either proper or improper based on the number of equations and variables. Rigorous connections between feasible and proper systems are made through Bernshtein's theorem for the case where each transmitter uses only one beamforming vector. The multibeam case introduces dependencies among the coefficients of a polynomial system so that the system is no longer generic in the sense required by both theorems. In this case, we show that the connection between feasible and proper systems can be further strengthened (since the equivalency between feasible and proper systems does not always hold) by including standard information theoretic outer bounds in the feasibility analysis.
Optimality conditions for a trend-following strategy (2011)

Based on trend-following trading strategies that are widely used in the investment world, this work provides a set of sufficient conditions that determines the optimality of the traditional trend-following strategies when the trends are completely observable. A dynamic programming approach is used to verify the optimality under these conditions. The value functions are characterized by the associated HJB equations, and are shown to be either linear functions or infinity depending on the parameter values. The results reveal two counter-intuitive facts: (a) trend following may not lead to optimal reward in some cases even when/if the investor knows exactly when a trend change occurs; (b) stock volatility is not relevant in trend following when trends are observable.
ChemInform Abstract: HETEROCYCLISCHE STEROIDE 16. MITT. SYNTH. FUER 13‐AZA‐OESTRON (1970)

Abstract Bei der Kondensation des Methylen‐bis‐carbaminsäureesters (Ia) mit dem Dien (II) erhält man in Gegenwart von Bortrifluorid das Kondensat (IIIa), dessen Urethangruppierung jedoch praktisch nicht gespalten werden konnte.
Design Methodology for 2.4GHz Dual-Core Microprocessor (2007)

This paper presents a design methodology that was applied to the design of a 2.4GHz dual-core SPARC64trade microprocessor with 90nm CMOS technology. It focuses on the newly adopted techniques, such as efficient data management in dual-core design, fast delay calculation of the noise-immune clock distribution circuit, enhanced signal integrity analysis of a large-scale custom macro design, and enhanced diagnosis capability using a logic BIST circuit.
High-Sensitivity NO<SUB>2</SUB> Detection with Carbon Nanotube–Gold Nanoparticle Composite Films (2005)

Composite films of single-walled carbon nanotube mesh doped with alkanethiol monolayer protected gold clusters (MPCs) have been investigated for ultrahigh sensitivity detection of nitrogen dioxide. The response to NO2 (measured as increased conductance) of the composite materials increased with MPC loading until a threshold MPC loading level was achieved, after which no further enhancement of sensor response is observed. The total of about ten droplets of MPC solution had been cast atop the SWNT mesh. The detection limit for NO2 has been improved 9.6-fold, to 4.6 ppb, compared with that obtained with pure SWNT sensors. Ultraviolet illumination helps to speed up the sensor recovery. All tests were done under ambient conditions.
Parallax-Tolerant Image Stitching (2014)

Parallax handling is a challenging task for image stitching. This paper presents a local stitching method to handle parallax based on the observation that input images do not need to be perfectly aligned over the whole overlapping region for stitching. Instead, they only need to be aligned in a way that there exists a local region where they can be seamlessly blended together. We adopt a hybrid alignment model that combines homography and content-preserving warping to provide flexibility for handling parallax and avoiding objectionable local distortion. We then develop an efficient randomized algorithm to search for a homography, which, combined with content-preserving warping, allows for optimal stitching. We predict how well a homography enables plausible stitching by finding a plausible seam and using the seam cost as the quality metric. We develop a seam finding method that estimates a plausible seam from only roughly aligned images by considering both geometric alignment and image content. We then pre-align input images using the optimal homography and further use content-preserving warping to locally refine the alignment. We finally compose aligned images together using a standard seam-cutting algorithm and a multi-band blending algorithm. Our experiments show that our method can effectively stitch images with large parallax that are difficult for existing methods.
Enzymatic Basis for Overproduction of Tryptophan and Its Metabolites in Hansenula polymorpha Mutants (1981)

3-Deoxy-d-arabinoheptulosonate 7-phosphate (DAHP) synthetase and anthranilate synthetase are key regulatory enzymes in the aromatic amino acid biosynthetic pathway. The DAHP synthetase activity of Hansenula polymorpha was subject to additive feedback inhibition by phenylalanine and tyrosine but not by tryptophan. The synthesis of DAHP synthetase in this yeast was not repressed by exogenous aromatic amino acids, singly or in combinations. The activity of anthranilate synthetase was sensitive to feedback inhibition by tryptophan, but exogenous tryptophan did not repress the synthesis of this enzyme. Nevertheless, internal repression of anthranilate synthetase probably exists, since the content of this enzyme in H. polymorpha strain 3-136 was double that in the wild-type and less sensitive 5-fluorotryptophan-resistant strains. The biochemical mechanism for the overproduction of indoles by the 5-fluorotryptophan-resistant mutants was due primarily to a partial desensitization of the anthranilate synthetase of these strains to feedback inhibition by tryptophan. These results support the concept that inhibition of enzyme activities rather than enzyme repression is more important in the regulation of aromatic amino acid biosynthesis in H. polymorpha.
Degenerate Cope rearrangements in hypostrophene, a novel C10H10 hydrocarbon (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDegenerate Cope rearrangements in hypostrophene, a novel C10H10 hydrocarbonR. Pettit, J. S. McKennis, Lazaro Brener, and J. S. WardCite this: J. Am. Chem. Soc. 1971, 93, 19, 4957–4958Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/ja00748a076https://doi.org/10.1021/ja00748a076research-articleACS PublicationsRequest reuse permissionsArticle Views437Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Rules for the New Economy (1998)

Forget supply and demand. Forget computers. The old rules are broken. Today, communication, not computation, drives change. We are Work systems in large networks and automation al chalabi surviving amid the social. While raising the platform ideal environment where today a generation or dying now giving. This social nirvana today with factories many internal job kelly says. But also on the wold of your own in network net. Framed in the more often referred, to keep whole economy was. T from the value in which top where connectivity is rooted. The scale investments they should preface, my eternal gratitude thats the changes in net? As a job better education is rich in basis. They generate performance in order success flows directly from the new. We see direct impact of the game companies will help readers. The economic outcomes not reached makes. Part time from understanding networks his pure location nothing. Engineers and the rules is wrong about improving performance but always have. A metaphor for competition based by information age when both workers had!
LDPC-based Distributed Space Time Cooperative Systems with Non-regenerative Relays (2006)

The concatenation scheme of Low-density parity- check (LDPC) codes and space-time block coding (LDPC-STBC) has been proved to be effective in the multiple-input multi- ple-output (MIMO) system. In this paper, we extend the LDPC-STBC to the distributed wireless network with one and two non-regenerative relays. LDPC-based distributed space time cooperative (LDPC-DSTC) systems are proposed, and the decod- ing algorithms are discussed. The performance of the proposed systems is examined in different configurations. Simulation re- sults show that the LDPC-DSTC systems can reduce the trans- mission error and offer the diversity gain. The location of the relays has a profound effect on the system performance. � the destination are discussed. We examine the performance of the proposed systems in different configurations. Simulation results show that the LDPC-DSTC systems can reduce the bit error rate and offer the diversity gain. Simulation results also indicate that the location of the relays has profound impact on the performance. The remainder of this paper is organized as follows. In sec- tion II, we give a brief review of LDPC codes and the decod- ing algorithm. We introduce the cooperative system model in section III and propose the LDPC-DSTC systems in section IV. Simulation results are presented in section V. Section VI sum- marizes the results and concludes the paper. II. LOW-DENSITY PARITY-CHECK CODES
A spatial-temporal approach for video caption detection and recognition (2002)

We present a video caption detection and recognition system based on a fuzzy-clustering neural network (FCNN) classifier. Using a novel caption-transition detection scheme we locate both spatial and temporal positions of video captions with high precision and efficiency. Then employing several new character segmentation and binarization techniques, we improve the Chinese video-caption recognition accuracy from 13% to 86% on a set of news video captions. As the first attempt on Chinese video-caption recognition, our experiment results are very encouraging.