gebhart/patrepeval huggingface dataset:
Constrained minimum cut for classification using labeled and unlabeled data (2005)

The use of unlabeled data has lead to an improvement in classification accuracy for a variety of classification problems via co-training approaches. In the co-training approach, the data has to be available in a dual view representation or two distinct classifiers are required. In this paper, a unified energy equation for classification combining labeled data and unlabeled data is introduced. This classification formulation is posed as a constrained minimum cut problem integrating labeling information on labeled data and cluster similarity information on unlabeled data for joint estimation. A novel constrained randomized contraction algorithm is proposed for finding the solution to the constrained minimum cuts problem. Experimental results on standard datasets and synthetic datasets are presented.
SIPs: Succinct Interest Points from Unsupervised Inlierness Probability\n Learning (2018)

A wide range of computer vision algorithms rely on identifying sparse\ninterest points in images and establishing correspondences between them.\nHowever, only a subset of the initially identified interest points results in\ntrue correspondences (inliers). In this paper, we seek a detector that finds\nthe minimum number of points that are likely to result in an\napplication-dependent "sufficient" number of inliers k. To quantify this goal,\nwe introduce the "k-succinctness" metric. Extracting a minimum number of\ninterest points is attractive for many applications, because it can reduce\ncomputational load, memory, and data transmission. Alongside succinctness, we\nintroduce an unsupervised training methodology for interest point detectors\nthat is based on predicting the probability of a given pixel being an inlier.\nIn comparison to previous learned detectors, our method requires the least\namount of data pre-processing. Our detector and other state-of-the-art\ndetectors are extensively evaluated with respect to succinctness on popular\npublic datasets covering both indoor and outdoor scenes, and both wide and\nnarrow baselines. In certain cases, our detector is able to obtain an\nequivalent amount of inliers with as little as 60% of the amount of points of\nother detectors. The code and trained networks are provided at\nhttps://github.com/uzh-rpg/sips2_open .\n
Studies on Fused Azoles: Synthesis of Several New Polyfunctionally Substituted Fused Pyrazoles (1993)

Abstract The synthesis of several new polyfunctionally substituted fused pyrazoles via reaction of 5-amino-3-methylthio-1H-pyrazole-4-carbonitrile (1) with different reagents is described.
Impact of omission of completion axillary lymph node dissection (cALND) or axillary radiotherapy (ax RT) in breast cancer patients with micrometastases (pN1mi) or isolated tumor cells (pN0[i+]) in the sentinel lymph node (SN): Results from the MIRROR study (2009)

CRA506 Background: The Dutch MIRROR study is the largest cohort study on pN1mi and pN0(i+) in the SN era with long-term follow-up, central pathology review (6th AJCC-classification), and separate analyses on the use of adjuvant systemic therapy (AST). In patients not receiving AST, pN1mi and pN0(i+) as final N-stage were shown to be independent prognosticators for disease-free survival (SABCS 2008, #23, oral). As a substantial number of patients in the MIRROR study did not undergo cALND or ax RT, we questioned whether this policy was safe in patients with pN1mi(sn) or pN0(i+)(sn). Methods: Patients operated for breast cancer in all Dutch hospitals in the years 1998–2005, having favorable primary tumor characteristics, and having undergone an SN biopsy without macrometastases as final N-stage were included. For this present research question, patients were categorized by their SN-stage. Median follow-up was 4.7 years. The Kaplan-Meier method was used to estimate 5-year axillary recurrence (AR) rates, and Cox regression was used to estimate the hazard ratios (HR). In the analyses, the effect of AST was taken into account. Results: In total, 835 patients with pN0(i-)(sn), 799 patients with pN0(i+)(sn), and 958 patients with pN1mi(sn) were included. AR rates, and HRs on AR are displayed below. Conclusions: Omission of cALND or ax RT in patients with pN1mi(sn) resulted in a significantly higher 5-year AR rate, even after correction for AST, and other patient and tumor characteristics. This indicates that patients with pN1mi(sn) should undergo cALND or ax RT to prevent AR. Support: The Netherlands Organization for Health Research and Development (ZonMw) and the Dutch Breast Cancer Trialists’ Group (BOOG). n 5-year AR(%) HR AR (95%CI)* pN0(i-)(sn) cALND 113 1.9 1.00 pN0(i-)(sn) SN 722 2.2 1.07 (0.23 - 4.94) pN0(i+)(sn) cALND or ax RT 459 1.1 1.00 pN0(i+)(sn) SN 340 1.7 2.14 (0.57 - 7.96) pN1mi(sn) cALND or ax RT 828 1.2 1.00 pN1mi(sn) SN 130 6.2 4.45 (1.46 - 13.54) * Corrected for AST, age, (log) tumor size, grade, hormone receptor status. No significant financial relationships to disclose.
[Psychiatric intensive therapy after acute alkaloid withdrawal syndrome]. (1979)

Two groups of patients (nine patients each) were treated for acute alcaloid-withdrawal-syndromes. One group was given peroral neuroleptic medication, the other was treated by neuroleptic cocktail administered via vena subclavia catheter. By statistic comparison of the two methods the superiority of the latter could be shown in that duration of withdrawal, the syndrome itself and hallucinatory transitional psychoses could be drastically reduced. A suitable prescription and dosages of the neuroleptic cocktail are presented. The results are compared to the ones in current literature.
Secretory Immunoglobulin A Blunts Gut-Mediated Priming of Neutrophils In Vitro (2008)

sIgA is the principal defense against potential pathogens at mucosal surfaces. Additional protective activity may be found in its ability to downregulate gut-mediated neutrophil priming. Although more work needs to be performed examining the role of sIgA in the pathogenesis of sepsis, this study shows that sIgA downregulates the measured determinants of neutrophil inflammatory potential.
Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities to define similarities and differences of HPV-positive versus HPV-negative cancers arising in the same tissue. Here, we describe genome-wide expression profiling of 84 HNCs, cervical cancers, and site-matched normal epithelial samples in which we used laser capture microdissection to enrich samples for tumor-derived versus normal epithelial cells. This analysis revealed that HPV&lt;sup&gt;+&lt;/sup&gt; HNCs and cervical cancers differed in their patterns of gene expression yet shared many changes compared with HPV&lt;sup&gt;−&lt;/sup&gt; HNCs. Some of these shared changes were predicted, but many others were not. Notably, HPV&lt;sup&gt;+&lt;/sup&gt; HNCs and cervical cancers were found to be up-regulated in their expression of a distinct and larger subset of cell cycle genes than that observed in HPV&lt;sup&gt;−&lt;/sup&gt; HNC. Moreover, HPV&lt;sup&gt;+&lt;/sup&gt; cancers overexpressed testis-specific genes that are normally expressed only in meiotic cells. Many, although not all, of the hallmark differences between HPV&lt;sup&gt;+&lt;/sup&gt; HNC and HPV&lt;sup&gt;−&lt;/sup&gt; HNC were a direct consequence of HPV and in particular the viral E6 and E7 oncogenes. This included a novel association of HPV oncogenes with testis-specific gene expression. These findings in primary human tumors provide novel biomarkers for early detection of HPV&lt;sup&gt;+&lt;/sup&gt; and HPV&lt;sup&gt;−&lt;/sup&gt; cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV&lt;sup&gt;+&lt;/sup&gt; cancers. [Cancer Res 2007;67(10):4605–19]&lt;/p&gt;&lt;/div&gt;
Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice (2004)

The control of liver regeneration remains elusive. Because reactive oxygen species (ROS) are able to mediate cell growth arrest and activate proteins that inhibit the cell cycle, ROS production may have a negative impact on liver regeneration. We examined how liver regeneration is affected by uncoupling protein-2 (UCP2), an inner mitochondrial membrane carrier that senses and negatively regulates superoxide production. Liver regeneration was monitored up to 5 days and was found to be significantly delayed in UCP2(-/-) mice after partial hepatectomy. Apoptosis rates in UCP2(+/+) and UCP2(- /-) liver remnants were similar, while parameters of cell proliferation indicated a diminished response in UCP2(- /-) mice with corresponding changes in the expression of key cell cycle regulatory proteins and prolonged activation of stress-responsive protein kinase p38. Levels of malondialdehyde, a marker of ROS generation and oxidant stress, were elevated in UCP2(- /-) livers at every examined time point. Liver remnants of UCP2(+ /+) mice 48 hours post-hepatectomy showed a fourfold increase in the expression of UCP2 protein primarily detected in hepatocytes. In conclusion, our results suggest that absent or insufficient UCP2 function in the regenerating liver results in increased ROS production and negatively modulates the control of cell cycle.
Acquired Immune Deficiency Syndrome (AIDS) (2001)

Abstract The acquired immune deficiency syndrome (AIDS) is a potentially fatal transmissible disease, caused by Human immunodeficiency virus type 1 (HIV‐1), which has claimed almost 20 million lives and infected over 34 million people. While there is as yet no cure or effective vaccine for AIDS, there are treatments that can forestall the development of overt disease and restore immune function.
Cannabis Use in Young Adult Cancer Patients (2019)

<b><i>Background:</i></b> The use of cannabis by young adult (YA) cancer patients is likely to increase as medical cannabis becomes more available. Clinically relevant data on cannabis use are needed to establish benchmarks for use, to identify patients who are more likely to use cannabis, and to assess outcomes associated with use. <b><i>Objective:</i></b> The current study sought to determine the rate of cannabis use in YA cancer patients ages 18 to 39, identify demographic and clinical correlates of use, and examine differences in moderate-to-severe symptoms between users and nonusers. <b><i>Methods:</i></b> We conducted a retrospective review of objectively measured tetrahydrocannabinol (THC), self-reported cannabis use, and cancer-related symptomatology in YA cancer patients in active treatment referred for comprehensive supportive care. <b><i>Results:</i></b> Approximately 30% of YA cancer patients tested positive for THC on urine drug testing. At the univariate level, cannabis users were more likely to be male, to have a lifetime history of smoking at least 100 cigarettes, and to be more recently diagnosed. Cannabis use was associated with moderate-to-severe symptomatology, including pain, nausea, lack of appetite, constipation, difficulty sleeping, and poorer overall well-being. <b><i>Conclusions:</i></b> YAs referred for comprehensive supportive care may be managing their cancer-related symptoms with cannabis. Further research is needed to better understand patients' perceptions of cannabis's therapeutic and adverse effects, in patients who used cannabis before diagnosis, and in patients who commenced use in response to a cancer diagnosis.
Multiple-Myeloma Bone Disease (1975)

A randomized double-blind study was carried out in 26 patients with multiple myeloma to compare the therapeutic effect of sodium fluoride (50 mg twice daily) plus calcium carbonate (1 g four times daily) and placebo. All patients also received melphalan and prednisone for one week every six weeks. Bone biopsies for microradiography and histology, and videodensitometry as well as conventional roentgenograms, 99mTc-polyphosphate bone scans, and bone densitometry of the mid and distal radius, were done initially and one year after therapy. Microradiography and videodensitometry studies revealed significant increases in bone formation (P less than 0.01) and bone mass (P less than 0.005) in the fluoride-calcium group. Bone trabeculae appeared thickened on roentgenograms of six of 13 fluoride-calcium-treated patients (P less than 0.02). Technetium bone scans and bone densitometry determinations proved insensitive for detection of skeletal changes. Fluoride calcium should be considered a useful adjunct in the treatment for multiple myeloma.
1 GeV CW nonscaling FFAG for ADS, and magnet parameters (2012)

Multi-MW proton driver capability remains a challenging, critical technology for many core HEP programs, particularly the neutrino ones such as the Muon Collider and Neutrino factory, and for high-profile energy applications such as Accelerator Driven Subcritical Reactors (ADS) and Accelerator Transmutation of Waste for nuclear power and waste management. Work is focused almost exclusively on an SRF linac, as, to date, no re-circulating accelerator can attain the 10-20 MW capability necessary for the nuclear applications. Recently, the concept of isochronous orbits has been explored and developed for nonscaling FFAGs using powerful new methodologies in FFAG accelerator design. Work is progressing on a stable, high-intensity, 1 GeV isochronous FFAG. Initial specifications of novel magnets with the nonlinear radial fields required to support isochronous operation are also reported here.
CheY's acetylation sites responsible for generating clockwise flagellar rotation in E scherichia coli (2014)

Stimulation of Escherichia coli with acetate elevates the acetylation level of the chemotaxis response regulator CheY. This elevation, in an unknown mechanism, activates CheY to generate clockwise rotation. Here, using quantitative selective reaction monitoring mass spectrometry and high-resolution targeted mass spectrometry, we identified K91 and K109 as the major sites whose acetylation level in vivo increases in response to acetate. Employing single and multiple lysine replacements in CheY, we found that K91 and K109 are also the sites mainly responsible for acetate-dependent clockwise generation. Furthermore, we showed that clockwise rotation is repressed when residue K91 is nonmodified, as evidenced by an increased ability of CheY to generate clockwise rotation when K91 was acetylated or replaced by specific amino acids. Using molecular dynamics simulations, we show that K91 repression is manifested in the conformational dynamics of the β4α4 loop, shifted toward an active state upon mutation. Removal of β4α4 loop repression may represent a general activation mechanism in CheY, pertaining also to the canonical phosphorylation activation pathway as suggested by crystal structures of active and inactive CheY from Thermotoga maritima. By way of elimination, we further suggest that K109 acetylation is actively involved in generating clockwise rotation.
Roots Redefined: Anatomical and Genetic Analysis of Root Development (1996)

The postembryonic development of plants is fueled by apical meristems, which are the local production sites of new cells that form a pattern of different cell types within an organ. The regularity of this pattern in the root yielded ideas on its formation from the meristem well before critical studies on the shoot apex were performed (e.g. The model plant Arabidopsis thaliana, which allows genetic dissection of root development, is a paragon of this regularity. In this Llpdate, we review recent studies on root anatomy and genetics that are allowing us to refine, and perhaps redefine, our understanding of organ development. We will focus on two pivotal aspects of root development: pattern formation and cell proliferation. Important work on other aspects of Arabidopsis roots, such as cell elongation/ morphogenesis, tropism, and cell size and shape, has been covered in recent reviews (Benfey and Schiefelbein, 1994;
Learning a Living: First Results of the Adult Literacy and Life Skills Survey (2005)

First Results of the Adult Literacy and Life Skills Survey OECD, Statistics Canada. \n250250250250250 both their health and emotional status using the extreme \npositive categories, whereas the larger group reports their physical and mental \nwell&amp;nbsp;...
Implementing a New Single Trip Multi Zone Frac Packing System with Integral Zone Isolation and Selective Production Capabilities (2008)

The Frac Pack completion of multiple zones in a single wellbore can be a complex and expensive operation. Effectively&lt;br&gt;performing Frac Pack treatments while still providing 100% zone selectivity can be critical to the mechanical and commercial&lt;br&gt;success of the well. Conventional techniques involve completing each zone separately requiring a minimum of 2 trips per zone&lt;br&gt;to perforate and install the Frac pack equipment.. Depending on the number of zones and well depth, the multiple trips&lt;br&gt;required to run the completion equipment in and out of the well can account for 25 to over 60% of the time required to&lt;br&gt;complete the well.
Progress towards III‐nitrides HEMTs on free‐standing diamond substrates for thermal management (2010)

Abstract In this paper, we discuss the progress in the application of silicon‐on‐diamond (SOD) and chemically vapour deposited (CVD) diamond wafers as an alternative solution to silicon and silicon carbide (SiC) substrates to enhance heat dissipation away from the active region of AlGaN/GaN high electron mobility transistors (HEMT) while decreasing thermal degradation due to thermal effects. The superior thermal conductivity and insulating properties of polycrystalline diamond (8–15 Wcm/K) free‐standing wafers have demonstrated certain advantages, mostly evident in the device performance and reliability. Two unique diamond growth applications engineered by sp 3 Diamond Technologies Inc., and Group4 Labs Inc., are discussed and device performance data is presented from early attempts to our most current device research efforts. As single‐crystalline diamond wafers (∼20 Wcm/K) become more accessible and affordable, it is expected to see significant improvement over the current state of this technology. magnified image Group4 employs an atomic bonding process of the AlGaN/GaN layers onto a polycrystalline CVD diamond wafer while sp 3 grows the AlGaN/GaN layers on a thin silicon template layer which covers the diamond.
Lectin-mediated flocculation of the yeast Saccharomycodes ludwigii NCYC 734 (1992)

Journal Article Lectin‐mediated flocculation of the yeast Saccharomycodes ludwigii NCYC 734 Get access M. Stratford, M. Stratford AFRC Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK Search for other works by this author on: Oxford Academic Google Scholar B.M. Pearson B.M. Pearson AFRC Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 14, Issue 5, 1 May 1992, Pages 214–216, https://doi.org/10.1111/j.1472-765X.1992.tb00688.x Published: 01 May 1992 Article history Received: 14 January 1992 Accepted: 03 February 1992 Published: 01 May 1992
Toward Practical Homomorphic Evaluation of Block Ciphers Using Prince. (2014)

We present the homomorphic evaluation of the Prince block cipher. Our leveled implementation is based on a generalization of NTRU. We are motivated by the drastic bandwidth savings that may be achieved by scheme conversion. To unlock this advantage we turn to lightweight ciphers such as Prince. These ciphers were designed from scratch to yield fast and compact implementations on resource-constrained embedded platforms. We show that some of these ciphers have the potential to enable near practical homomorphic evaluation of block ciphers. Indeed, our analysis shows that Prince can be implemented using only a 24 level deep circuit. Using an NTRU based implementation we achieve an evaluation time of 3.3 seconds per Prince block – one and two orders of magnitude improvement over homomorphic AES implementations achieved using NTRU, and BGV-style homomorphic encryption libraries, respectively.
Analytical placement for heterogeneous FPGAs (2012)

We present HeAP, an analytical placement algorithm for heterogeneous FPGAs comprised of LUT-based logic blocks, multiplier/DSP blocks and block RAMs. Specifically, we adapt a state-of-the-art ASIC-based analytical placer to target FPGAs with heterogeneous blocks located at discrete locations throughout the fabric. Our placer also handles macros of LUT-based blocks with specific layout requirements, such as carry chains. Results show that our placer delivers a 4× speedup, on average, compared to Altera's non-timing driven flow, at the cost of a 5% increase in postrouted wirelength, and an 11× speedup compared to Altera's timing-driven flow, at the cost of a 4% increase in post-routed wirelength and a 9% reduction in maximum operating frequency. We also compare with an academic simulated annealing-based placer and demonstrate a 7.4× runtime advantage with 6% better placement quality.
Self-aligned nickel-mono-silicide technology for high-speed deep submicrometer logic CMOS ULSI (1995)

A nickel-monosilicide (NiSi) technology suitable for a deep sub-micron CMOS process has been developed. It has been confirmed that a nickel film sputtered onto n/sup +/- and p/sup +/-single-silicon and polysilicon substrates is uniformly converted into the mono-silicide (NiSi), without agglomeration, by low-temperature (400-600/spl deg/C) rapid thermal annealing. This method ensures that the silicided layers have low resistivity. Redistribution of dopant atoms at the NiSi-Si interface is minimal, and a high dopant concentration is achieved at the silicide-silicon interface, thus contributing to low contact resistance. This NiSi technology was used in the experimental fabrication of deep-sub-micrometer CMOS structures; the current drivability of both n- and p-MOSFET's was higher than with the conventional titanium salicide process, and ring oscillator constructed with the new MOSFET's also operated at higher speed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characterization and optimization of a simple, repeatable system for the long term in vitro culture of aligned myotubes in 3D (2011)

Increased recent research activity in exercise physiology has dramatically improved our understanding of skeletal muscle development and physiology in both health and disease. Advances in bioengineering have enabled the development of biomimetic 3D in vitro models of skeletal muscle which have the potential to further advance our understanding of the fundamental processes that underpin muscle physiology. As the principle structural protein of the extracellular matrix, collagen-based matrices are popular tools for the creation of such 3D models but the custom nature of many reported systems has precluded their more widespread adoption. Here we present a simple, reproducible iteration of an established 3D in vitro model of skeletal muscle, demonstrating both the high levels of reproducibility possible in this system and the improved cellular architecture of such constructs over standard 2D cell culture techniques. We have used primary rat muscle cells to validate this simple model and generate comparable data to conventional established cell culture techniques. We have optimized culture parameters for these cells which should provide a template in this 3D system for using muscle cells derived from other donor species and cell lines.