gebhart/patrepeval huggingface dataset:
DDRE-19. SPIDER VENOMS AS SOURCES OF MOLECULES FOR NEW CANCER TREATMENTS: THE EFFECTS OF THE SNX-482 PEPTIDE ON MACROPHAGE MODULATION (2020)

Abstract Malignant primary brain tumors remain among the most difficult cancers to treat. In malignant tissues, macrophages are accumulated in a high infiltration being known as tumor-associated macrophages (TAMs). These cells are associated with poor prognostics in many types of cancer. Studies in our group demonstrated that the venom of Phoneutria nigriventer (PnV), a wandering spider from South America, has reduced the development of glioblastoma (GBM) in a murine model, inducing a large infiltrate of TAMs. Subsequently, in vitro results demonstrated that PnV activates macrophages, increasing the ability to kill tumor cells. The aim of this study was to analyze the effects of the peptide SNX-482 presented in the venom of Hysterocrates gigas in macrophages for further correlation with the PnV. Macrophages were differentiated from bone marrow precursors collected from male C57BL6 mice and differentiated for 7 days with M-CSF. These cells were used for polarization and coculture with T cells and analyzed by flow cytometry. PCR Array was also performed (QIAGEN) for the analysis of gene expression. The results showed that SNX-482 could activate macrophages in a not dose-dependent response. There was an increase in the main activation markers (CD40, CD80, CD86, CD68, CD83, and MHCII). The polarization indicated that the peptide potentiated the proinflammatory effect of M1 macrophages (increased MHCII and iNOS). The screening of 86 cancer-related genes showed that the Ccr4, Pdcd1, Gzmb, and IFN-γ genes had an increase in their expression. Furthermore, we developed in C57BL/6 mouse a pre-clinical model of intracranial glioblastoma using the Gl261 cell line. The results showed an applied-easy-safe model that could alter the gene expression of cancer markers. Taken together, all the results contributed to increasing the knowledge about the peptide SNX-482 and the model for further pre-clinical assays of glioblastoma, making a great advance in the development of new treatments.
Online Multi-Kernel Learning with Orthogonal Random Features (2018)

Kernel-based methods have well-appreciated performance in various nonlinear learning tasks. Most of them rely on a preselected kernel, whose prudent choice presumes task-specific prior information. To cope with this limitation, multi-kernel learning has gained popularity thanks to its flexibility in choosing kernels from a prescribed kernel dictionary. Leveraging the random feature approximation and its recent orthogonality-promoting variant, the present contribution develops an online multi-kernel learning scheme to infer the intended nonlinear function `on the fly.' Performance analysis shows that the novel algorithm can afford sublinear regret. Numerical tests on real datasets are carried out to showcase the effectiveness of the proposed algorithms.
Failure analysis of evaporated metal interconnections at contact windows (1970)

An analysis of the open metallization problem at oxide steps at the surface of planar devices is described. This failure mechanism is essentially based upon the presence of a film discontinuity which grows during the evaporation process at the interface of coarse and dense crystal structures of the evaporated film. The growth rate of the coarse surface is somewhat larger than that of the normal surface. This mismatch in growth rates gives rise to the film discontinuity due to the self-shadowing effect by the former surface. The film discontinuity is apt to occur at the sharp step of phosphosilicate glass because of the following two reasons: 1) a large vapor-incidence angle to the perpendicular side wall; 2) a spontaneous growth of the coarse surface at the sharp edge of the step. Techniques investigated to improve the interconnection reliability include : 1) evaporation at elevated substrate temperature (∼300°C), 2) reduction of the thickness of phosphosilicate glass, 3)perpendicular vapor incidence to the substrate, and 4) protection of the discontinuity against corrosive agents.
A simple technique for the rapid diagnosis of rabies in formalin-preserved brain. (1982)

A simple technique is described for the rapid diagnosis of rabies in formalin-preserved brain. Brain tissue was emulsified, washed with phosphate-buffered saline and digested with trypsin. The digested material was stained according to conventional immunofluorescent procedures. Digestion with trypsin markedly enhanced the staining of rabies inclusions and eliminated non-specific staining of formalin-preserved brain. The method seems to be more accurate than histological examination.
Polymerization of Ethylene Terephthalate Cyclic Oligomers with Antimony Trioxide (2000)

Conditions for polymerizing ethylene terephthalate cyclic oligomers (ETCs) with the catalyst antimony trioxide were investigated with the ultimate goal in mind of using ETCs to produce high-performance poly(ethylene terephthalate) (PET) composites. The ETCs used were prepared both by a direct synthesis method and by cyclodepolymerization (CDP) in dilute solution. ETCs prepared exhibited a distribution of oligomeric species displaying a broad melting range, the uppermost end of which lies at 290 °C. In the case of ETCs prepared by CDP, purified ETCs (p-ETCs) were prepared by eliminating remaining impurities including linear oligomers and cyclic oligomers containing the diethylene glycol (DEG) unit using dichloromethane and tetrahydrofuran. A homogeneous mixture of ETCs prepared by the direct synthesis method or p-ETCs with antimony trioxide was successfully polymerized to high molecular weight (MW) PET (Mn ≥ 25 000) at 293 °C within 15 min. The lower the contents of remaining impurities, the higher the MW of the resultant PET. The PET of highest MW (Mn = 32 000) was obtained from polymerization of p-ETCs with bismuth trioxide at 293 °C for 15 min. PET polymerized from p-ETCs showed the same thermal behavior as did the commercial one. In this research, a useful method of PET recycle by using ETCs was successfully established.
PERFORMANCE ANALYSIS OF A KINEMATIC TERRESTRIAL LIDAR SCANNING SYSTEM (2006)

Terrapoint has developed a novel kinematic terrestrial based laser scanning system that is deployed on a passenger vehicle. LIDAR, digital imagery and digital video is collected from the survey platform at speeds up to 100 km/h. The system is georeferenced using a GPS/INS system. Obtaining an accurate and reliable trajectory for the ground based platform is a much more difficult and challenging task than that of an airborne platform due primarily to frequent GPS signal outages caused by obstructions such as buildings, terrain and vegetation. However, the simultaneous collection of LIDAR data from the vehicle platform provides an accurate 3D reference that can be utilized to check the reliability, accuracy and consistency of the GPS/INS derived vehicle trajectory. Methods of utilizing the LIDAR data to validate and improve the GPS/INS trajectory will be presented. A comparison of tightly and loosely coupled GPS/INS trajectories and their respective impact on positioning accuracy will also be presented. Finally, overall absolute accuracy of survey results obtained with the kinematic terrestrial LIDAR system (when compared with dense DGPS ground control) will be presented and discussed.
Kristine M. Alpi, AHIP, FMLA, Medical Library Association President, 2021–2022 (2021)

In this profile, Kristine M. Alpi, AHIP, FMLA, Medical Library Association (MLA) president, 2021-2022, is described as committed to public health, professional development, and the growth and evolution of MLA. She teaches and speaks on the shared health impact from interactions among animals, humans, and the environment, and she mentors graduate students and fellows in librarianship and informatics. Alpi earned her PhD in educational research and policy analysis in 2018 and directs the Oregon Health & Science University Library.
Profiling DNN Workloads on a Volta-based DGX-1 System (2018)

High performance multi-GPU systems are widely used to accelerate training of deep neural networks (DNNs) by exploiting the inherently massive parallel nature of the training process. Typically, the training of DNNs in multi-GPU systems leverages a data-parallel model in which a DNN is replicated on every GPU, and each GPU performs Forward Propagation (FP), Backward Propagation (BP) and, Weight Update (WU). We analyze the WU stage that is composed of collective communication (e.g., allReduce, broadcast), which demands very efficient communication among the GPUs to avoid diminishing returns when scaling the number of GPUs in the system. To overcome this issue, different data transfer mechanisms and libraries have been introduced by NVIDIA, and adopted by high-level frameworks to train DNNs. In this work, we evaluate and compare the performance of peer-to-peer (P2P) data transfer method and NCCL library-based communication method for training DNNs on a DGX-1 system consisting of 8 NVIDIA Volta-based GPUs. We profile and analyze the training of five popular DNNs (GoogLeNet, AlexNet, Inception-v3, ResNet and LeNet) using 1, 2, 4 and 8 GPUs. We show the breakdown of the training time across the FP+ BP stage and the WU stage to provide insights about the limiting factors of the training algorithm as well as to identify the bottlenecks in the multi-GPU system architecture. Our detailed profiling and analysis can help programmers and DNN model designers accelerate the training process in DNNs.
In situ optical biopsy with a confocal microendoscope (2002)

A confocal microendoscope for in situ optical biopsy has been developed. The system couples a slit-scan confocal fluorescence microscope to an optical catheter, consisting of a coherent fiber-optic imaging bundle, or a fiber bundle with a miniature objective and hydraulic focusing mechanism. The confocal microendoscope provides adequate image quality to visualize individual cells and subcellular structures. Vital fluorescent dyes are used with the system as selective stains for histopathologic evaluation of disease.
Gastric cancer following pancreaticoduodenectomy: Experience from a high-volume center and review of existing literature (2020)

Long-term survivors after pancreaticoduodenectomy who develop nonspecific gastrointestinal complaints should be evaluated carefully for complications including gastric malignancy. This may serve as an opportunity to intervene on tumors that typically present at an advanced stage and with aggressive histology.
Electrical conduction mechanism and breakdown property in sputter-deposited silicon dioxide films on polycrystalline silicon (1989)

Silicon dioxide films are sputter deposited on polycrystalline silicon (polysilicon) in an oxygen-argon atmosphere at 200 °C. Electrical conduction and breakdown are measured at various gate fields and temperatures. In addition to the Fowler–Nordheim tunneling current reported for thermal oxide, the sputter-deposited films have another, newly identified high-activation-energy current as electrical conduction mechanisms. The high-activation-energy current contribution to the total current is considerably reduced by increasing the oxygen mixing ratio and/or by decreasing the sputtering gas pressure, resulting in a considerable total current reduction. High-activation-energy current contributes little to the triggering of breakdown, unlike Fowler–Nordheim tunneling injections. In contrast to polysilicon thermal oxide, sputter-deposited films on polysilicon have no observable field enhancement in Fowler–Nordheim tunneling current, which indicates smooth surfaces. Thus, electrical properties in oxygen-argon sputter-deposited films on polysilicon are explained by high-activation-energy current and Fowler–Nordheim tunneling current.
Supplemental Figure 1 from Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors (2023)

&lt;p&gt;Study design.&lt;/p&gt;
A Case of Acute Cholecystitis Caused by &lt;italic&gt;Stenotrophomonas maltophilia&lt;/italic&gt; Bacteremia (2014)

Stenotrophomonas maltophilia ( S. maltophilia) 1960
Structure of the Complex of Cdc42Hs with a Peptide Derived from P-21 Activated Kinase, (2000)

Cdc42Hs is a member of the Ras superfamily of GTPases and initiates a cascade that begins with the activation of several kinases, including p21-activated kinase (PAK). We have previously used a 46 amino acid fragment of PAK (PBD46) to define the binding surface on Cdc42Hs [Guo et al. (1998) Biochemistry 37, 14030-14037]. Here we describe the three-dimensional solution structure of the Cdc42Hs. GMPPCP-PBD46 complex. Heteronuclear NMR methods were used to assign resonances in the complex, and approximately 2400 distance and dihedral restraints were used to calculate a set of 20 structures using a combination of distance geometry, simulated annealing, and chemical shift and Ramachandran refinement. The overall structure of Cdc42Hs in the complex differs from the uncomplexed structure in two major aspects: (1) the first alpha helix is reoriented to accommodate the binding of the peptide and (2) the regions corresponding to switch I and switch II are less disordered. As suggested by our previous work (Guo et al., 1998) and similar to the complex between Cdc42Hs and fACK [Mott et al. (1999) Nature 399, 384-388], PBD46 forms an intermolecular beta-sheet with beta2 of Cdc42Hs and contacts both switch I and switch II. The extensive binding surface between PBD46 and Cdc42Hs can account for both the high affinity of the complex and the inhibition by PBD46 of GTP hydrolysis.
A Novel Technique for Opus Vermiculatum Mosaic Rendering (2006)

In this paper we present a method to generate a digital mosaic starting from a raster input image. Mosaics generation of artistic quality is challenging. The basic elements, the tiles, typically small polygons, must be packed tightly, emphasizing orientations chosen by the artist. An adhoc boundaries detection have to be performed according to the directional guidelines. Different mosaic styles can be automatically rendered, depending on artistic techniques considered (“opus musivum”, “opus vermiculatum”, etc.). The proposed method is able to reproduce the colors of the original image emphasizing relevant boundaries by placing tiles along their direction. The boundaries detection is based on the statistical region merging algorithm. In particular the technique is able to reproduce the “opus vermiculatum” mosaic style. Several examples reported in the paper show how the right mixture of mathematical tools together with century proved ideas from mosaicists may lead to impressive results.
Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France (2009)

The term "gray-zone" lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein-Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel's proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters.
Staghorn Renal Stones: Value of Bench Surgery and Autotransplantation (1977)

Two patients with staghorn renal calculi underwent bench surgery and autotransplantation. A discussion is presented on the value of an extracorporeal procedure for patients with staghorn calculi associated with renal artery or pyeloureteral junction stenosis.
Indirect Combustion Noise: Experimental Investigation of the Vortex Sound Generation in a Choked Convergent-divergent Nozzle (2012)

International audience
Self-Assembled Carbon Nanotubes for Electronic Circuit and Device Applications (2006)

Functionalized, self-assembled carbon nanotubes are discussed in relation to electronic devices, circuits, and architectures. A computational approach is described using density functional theory coupled with nonequilibrium Green function theory for modeling the device electrical properties. While most current work has focused on carbon nanotubes used for field-effect transistors, carbon nanotubes connected by molecular linkers can act electronically as resonant tunneling diodes. The addition of resonant tunneling diodes to transistor circuitry allows for greater functionality with fewer devices. The greatest advantage of this for self-assembly is simplified circuit topology. The resonant tunneling operation is demonstrated both theoretically and experimentally for carbon nanotube-L-R-L-carbon nanotube systems in which L is the amide linker and R is either C2H4 or single-strand DNA.
Mix design for fine-grained exposed aggregate PCC pavement (2011)

It is essential for transportation agencies to make an effort to provide safe and smooth pavement. Fine-grained exposed aggregate Portland cement concrete (PCC) pavement has been successfully used in Europe and Japan as an alternative solution to simultaneously reduce the noise level of PCC pavement and to enhance long-term skid resistance. As the advantages of the fine-grained exposed aggregate PCC pavement are well recognised and there are a number of research reports, more comprehensive and thorough research is sought for better design and field practice specifications. This study aims to investigate the fundamental properties of the exposed aggregate PCC pavement, and expects to provide useful information for design and construction. An appropriate type of coarse aggregate mix design of exposed aggregate PCC pavement was suggested with consideration of noise reduction, skid resistance and strength of exposed aggregate PCC pavement.
A Coordination Gelator That Shows a Reversible Chromatic Change and Sol−Gel Phase-Transition Behavior upon Oxidative/Reductive Stimuli (2004)

A novel coordination gelator exhibits reversible chromatic and sol-gel phase-transition phenomena triggered by thermal and chemical stimuli.
Preface to the third edition (2006)

For the second edition, we included more examples and exercises, and a new chapter on that much abused diagram, the graph. For the third, there are new examples and fresh exercises. There are a number of new entries for words that we overlooked or have since and inadvisably become more prevalent. In the 15 years since the first edition, we have not detected any great change in the attitudes of medical writers to the way they write. For this reason, the introductory chapters, which attempt to explain the reasons for poor medical writing, remain much as they were in the previous two editions.
The significance of equol in relation to the oestrogenic responses in sheep ingesting clover with a high formononetin content (1968)

Equol (7,4'-dihydroxyisoflavan), a metabolite in sheep of the dietary isoflavone formononetin, was found to be oestrogenic in mice. By subcutaneous administration it had about one-quarter of the activity of genistein. Equol (35–68 µg/100 ml) was found in the peripheral blood of sheep 4–24 hr after first feeding with red clover (Trifolium pratense) pellets, and represented 9–68% of the "free" and 23–72% of the conjugated "phyto-oestrogens" in the plasma. In ewes grazing red clover, equol was found in the plasma (50 µg/100 ml) and in the uterine tissue (46 µg/uterus) and represented in both instances more than 70% of the extracted "phyto-oestrogen". It is concluded that equol is probably of major importance in relation to the oestrogenic activity found in sheep ingesting clover with a high formononetin content. In guinea-pigs, equol (32–71 µg/100 ml) was found in plasma samples 4–16 hr (day 3) after feeding with red clover pellets. Another probable metabolite of formononetin, referred to as metabolite "A" and tentatively identified as demethylated angolensin (2,4-dihydroxyphenyl-p-hydroxyphenylethylketone), was also noted in the plasma of sheep and guinea-pigs after ingesting red clover.
The MPEG-4 systems and description languages: A way ahead in audio visual information representation (1997)

The state of the standardization of the Systems part of ISO/IEC JTC1/SC29/WG11 (MPEG-4 Systems) as specified early 1997 is presented. First, a rationale and the architecture of the complete Systems are described. Based on the rapid technological advances in software and in hardware, the MPEG-4 Systems provides for a framework for the integration of natural and synthetic streamed and synchronised media. The different fields of interest in Systems are then developed from the description of audiovisual scenes to the definition of the multiplex. The programmability of the standard is described for composition and decompression and the language adopted by MPEG-4 on purpose of syntax description is fully detailed. Finally, a conclusion and the future evolutions of the specifications are presented.
Transition to Digital Recording: An Emerging Trend Influencing all Analog Signal Recording Applications (1987)

Because it is not necessary to maintain as high a carrier-to-noise ratio for digital recording as for analog recording, the recording density of digital recording systems can be made much higher. The recording density upper limit can be set to ensure the data recovery with adequate bit-error ratio necessary for particular applications. By adopting digital recording, it is possible to obtain improved output signal characteristics with reduced tape use. Within a few years all newly introduced recorders, for various applications including audio, video, sensor outputs, and data, will be data recorders. Only a small number of recording formats are necessary to meet all data storage and retrieval requirements. Designed-for-application input and output devices make a general-purpose data recorder suitable for particular applications.
Absorption, distribution in tissues and routes of excretion of preparation IF-ROM-196 administered to rats orally. (1976)

The metabolic fate of a new coronary vasodilating derivative of ethylenediamine (ROM--196) labeled with 14C has been studied in Wistar rats. Dynamics of absorption of the preparation, its distribution in tissues and excretion in urine, feces and bile and expiratory air were investigated. The preparation is quickly absorbed from the gastrointestinal tract and readily penetrates to the tissues. It is excreted mainly in the stools and urine.