gebhart/patrepeval huggingface dataset:
Kluyvera, a new (redefined) genus in the family Enterobacteriaceae: identification of Kluyvera ascorbata sp. nov. and Kluyvera cryocrescens sp. nov. in clinical specimens (1981)

Kluyvera is proposed as a new genus for the group of organisms formerly known as Enteric Group 8 (synonym = API group 1). Strains of Kluyvera share the properties of most members of the family Enterobacteriaceae: they are gram-negative rods, motile with peritrichous flagella, catalase positive, and oxidase negative; they grow on MacConkey agar, ferment D-glucose with the production of acid and gas, and are susceptible to many antibiotics. Strains are usually indole positive, methyl red positive, Voges-Proskauer negative, citrate positive, H2S (triple sugar iron) negative, urea negative, phenylalanine deaminase negative, lysine decarboxylase positive, arginine dihydrolase negative, and ornithine decarboxylase positive. Kluyvera strains ferment many of the sugars and polyhydroxyl alcohols used in identification. By deoxyribonucleic acid-deoxyribonucleic acid hybridization, strains of Kluyvera were divided into three groups. Kluyvera ascorbata is proposed as the type species for the genus. Most strains of K. ascorbata have been isolated from clinical specimens. K. cryocrescens is proposed as the second species. It was occasionally isolated from clinical specimens, but it was isolated more commonly from the environment. Kluyvera species group 3 was heterogeneous, but was distinct from the two named species by deoxyribonucleic acid hybridization. This group was rare, so no species name will be proposed at this time. K. ascorbata can be differentiated from K. cryocrescens by its positive ascorbate test, inability to grow at 5 degrees C in a refrigerator, and smaller zones of inhibition around carbenicillin and cephalothin disks. The test normally used for identification does not clearly differentiate these two species. Kluyvera species are probably infrequent opportunistic pathogens. The most common source is sputum, where they are probably not clinically significant. Five strains have been from blood cultures. More information is needed about the incidence and clinical significance of the genus Kluyvera.
A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactonesBen E. Evans, Kenneth E. Rittle, Carl F. Homnick, James P. Springer, Jordan Hirshfield, and Daniel F. VeberCite this: J. Org. Chem. 1985, 50, 23, 4615–4625Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://doi.org/10.1021/jo00223a037RIGHTS & PERMISSIONSArticle Views928Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Rescue cerclage when foetal membranes prolapse into the vagina (2017)

A cross-sectional study was conducted to evaluate the efficacy of rescue cerclage in patients with a dilated cervix and prolapsed foetal membranes. Thirty-five patients presenting with cervical dilatation and prolapsed foetal membranes were included in the study. A McDonald cerclage was placed in 27 patients. The duration of pregnancy prolongation and the number of deliveries after 28 weeks were evaluated. The median prolongation of pregnancy after cerclage placement differed significantly between the cerclage and bed-rest groups (64 days versus 13.5 days). Of the 27 patients who had cerclage, 17 (63%) delivered after 28 weeks of gestation, whereas all patients in the bed-rest group delivered before 28 weeks of gestation. The take-home baby rate was 63% in the cerclage group. When pregnancies were complicated by cervical dilatation with membrane prolapse into the vagina, placement of a McDonald cerclage in appropriately selected patients can be a beneficial therapeutic option. Impact statement Although the effectiveness and safety of rescue cerclage is controversial, our study provides strong support for the notion that cervical cerclage accompanied by long-term broad-spectrum antibiotics improves the perinatal outcomes in singleton gestations with membrane prolapsed into the vagina. Further prospective randomised trial is required to prove these findings.
Concerted Proton–Electron Transfer Reactivity at a Multimetallic Co4O4 Cubane Cluster (2020)

High-valent oxocobalt(IV) species have been invoked as key intermediates in oxidative catalysis, but investigations into the chemistry of proton-coupled redox reactions of such species have been limited. Herein, the reactivity of an established water oxidation catalyst, [Co<sub>4</sub>O<sub>4</sub>(OAc)<sub>4</sub>(py)<sub>4</sub>][PF<sub>6</sub>], toward H-atom abstraction reactions is described. Mechanistic analyses and density functional theory (DFT) calculations support a concerted proton-electron transfer (CPET) pathway in which the high energy intermediates formed in stepwise pathways are bypassed. Natural bond orbital (NBO) calculations point to cooperative donor-acceptor σ interactions at the transition state, whereby the H-atom of the substrate is transferred to an orbital delocalized over a Co<sub>3</sub>(μ<sub>3</sub>-O) fragment. The mechanistic insights provide design principles for the development of catalytic C-H activation processes mediated by a multimetallic oxo metal cluster.
A metal-based tumour necrosis factor-alpha converting enzyme inhibitor (2015)

We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
Integration of nomadic devices with automotive user interfaces (2009)

The number of nomadic devices such as PDAs, MP3 players and especially cell phones has largely grown in the last years; Indeed, cell phones are becoming powerful, always-connected computers that store a lot of personal information (contacts, calendar, personal videos and pictures). The small size of their keyboards and screens is a major limitation of nomadic devices, hampering their utilization in vehicles. Handling them while driving may distract the user and increases the risk of accident, and it is illegal in some countries. According to the Web 2.0 vision, the Internet is a platform rather than a mere source of information. The interfaces of Ajax-based applications are user friendly, and they allow storing personal information and preferences. Google Maps is a good example of this philosophy. Nowadays, it is a familiar tool in desktop computers to locate destinations and to plan routes at home. In this paper we propose a new model of Web 2.0 information migration to nomadic devices that facilitates is access to cars.
Supplementary Table 1, Figures 1-8 from Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes (2023)

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Nierentransplantation – Besonderheiten bei älteren Dialysepatienten (2011)

Die Zahl der über 60 Jahre alten Patienten an der Dialyse steigt kontinuierlich an. Auch wenn diese Patienten aufgrund des Alters über das terminale Nierenversagen hinaus an einer Reihe weiterer Krankheiten leiden, die überwiegend das kardiovaskuläre System betreffen, so stellt sich für diese Patientengruppe die Frage nach dem Nutzen und dem Risiko einer möglichen Nierentransplantation ebenso. Die Transplantat- und Patientenüberlebensrate liegt unter derjenigen von jüngeren Patienten. Trotzdem führt auch die Transplantation älterer Menschen zu einer Verbesserung der Lebensqualität und zu einer Verlängerung der Lebenserwartung. Die Art und das Ausmaß der Begleiterkrankungen, immunologische Faktoren, die Qualität des Spenderorgans, die Zeit auf der Warteliste und weitere Faktoren beeinflussen die Langzeitergebnisse nach einer Transplantation. Im Eurotransplantbereich wurde ein Allokationssystem etabliert, das Eurotransplant-Senioren-Programm, das der zunehmenden Zahl älterer Patienten auf der Warteliste, die von einer möglichst frühen Transplantation profitieren, Rechnung trägt.
Subjective Evaluation of Forms in an Immersive Environment (2007)

User's perception of product, by essence subjective, is a major topic in marketing and industrial design. Many methods, based on users' tests, are used so as to characterise this perception. We are interested in three main methods: multidimensional scaling, semantic differential method, and preference mapping. These methods are used to built a perceptual space, in order to position the new product, to specify requirements by the study of user's preferences, to evaluate some product attributes, related in particular to style (aesthetic). These early stages of the design are primordial for a good orientation of the project. In parallel, virtual reality tools and interfaces are more and more efficient for suggesting to the user complex feelings, and creating in this way various levels of perceptions. In this article, we present on an example the use of multidimensional scaling, semantic differential method and preference mapping for the subjective assessment of virtual products. These products, which geometrical form is variable, are defined with a CAD model and are proposed to the user with a spacemouse and stereoscopic glasses. Advantages and limitations of such evaluation is next discussed..
A Ground Systems Template for Remote Sensing Systems (2002)

Spaceborne remote sensing using gamma and X‐ray spectrometers requires particular attention to the design and development of reliable systems. These systems must ensure the scientific requirements of the mission within the challenging technical constraints of operating instrumentation in space. The Near Earth Asteroid Rendezvous (NEAR) spacecraft included X‐ray and gamma‐ray spectrometers (XGRS), whose mission was to map the elemental chemistry of the 433 Eros asteroid. A remote sensing system template, similar to a blackboard systems approach used in artificial intelligence, was identified in which the spacecraft, instrument, and ground system was designed and developed to monitor and adapt to evolving mission requirements in a complicated operational setting. Systems were developed for ground tracking of instrument calibration, instrument health, data quality, orbital geometry, solar flux as well as models of the asteroid’s surface characteristics, requiring an intensive human effort. In the future, missions such as the Autonomous Nano‐Technology Swarm (ANTS) program will have to rely heavily on automation to collectively encounter and sample asteroids in the outer asteroid belt. Using similar instrumentation, ANTS will require information similar to data collected by the NEAR X‐ray/Gamma‐Ray Spectrometer (XGRS) ground system for science and operations management. The NEAR XGRS systems will be studied to identify the equivalent subsystems that may be automated for ANTS. The effort will also investigate the possibility of applying blackboard style approaches to automated decision making required for ANTS.
Feature-aggregated spatiotemporal spine surface estimation for wearable patch ultrasound volumetric imaging (2023)

Clear identification of bone structures is crucial for ultrasound-guided lumbar interventions, but it can be challenging due to the complex shapes of the self-shadowing vertebra anatomy and the extensive background speckle noise from the surrounding soft tissue structures. Therefore, in this work, we will present our method for estimating the vertebra bone surfaces by using a spatiotemporal U-Net architecture learning from the B-Mode image and aggregated feature maps of hand-crafted filters. Additionally, we are integrating this solution with our patch-like wearable ultrasound system to capture the repeating anatomical patterns and image the bone surfaces from multiple insonification angles. 3D bone representations can then be created for interventional guidance. The methods are evaluated on spine phantom image data collected by our proposed “Patch” scanner, and our systematic ablation experiment shows that improved accuracy can be achieved with the proposed architecture. Equipped with this surface estimation network, our wearable ultrasound system can potentially provide intuitive and accurate interventional guidance for clinicians in an augmented reality setting.
Anhydrous Proton-Conducting Membranes for Fuel Cells (2005)

Polymeric electrolyte membranes that do not depend on water for conduction of protons are undergoing development for use in fuel cells. Prior polymeric electrolyte fuel-cell membranes (e.g., those that contain perfluorosulfonic acid) depend on water and must be limited to operation below a temperature of 125 C because they retain water poorly at higher temperatures. In contrast, the present developmental anhydrous membranes are expected to function well at temperatures up to 200 C. The developmental membranes exploit a hopping-and-reorganization proton- conduction process that can occur in the solid state in organic amine salts and is similar to a proton-conduction process in a liquid. This process was studied during the 1970s, but until now, there has been no report of exploiting organic amine salts for proton conduction in fuel cells.
Liver Cancer Emergence Associated with Antiviral Treatment: An Immune Surveillance Failure? (2017)

The availability of new direct antiviral agents to safely and effectively treat the hepatitis C virus represents a major advancement in the field of liver disease. Most patients achieve complete viral eradication sustained over time. In addition, the administration of these new agents is safe and does not require limitations when liver function is impaired. Some now expect the hepatitis C virus to be completely eradicated in a few years. However, not all data are positive. In April 2016, we published a cohort study suggesting that viral eradication with the new agents could be associated in time with the emergence of recurrent cancer sites in patients previously treated for hepatocellular carcinoma. In this review, we update our report and summarize the data provided in recent publications. We also speculate about the mechanisms for cancer emergence and stress the need for further studies.
Wavelength-time spreading optical CDMA system using wavelength multiplexers and mirrored fiber delay lines (2000)

We propose a two-dimensional (2-D) code family and transmitter/receiver structures for incoherent multi-wavelength-time spread optical CDMA networks. The combination of metal-coated reflection delay lines and arrayed waveguide gratings (AWG) gives the proposed optical coder/decoder much enhanced flexibility in accommodating different code sets. Successful encoding/decoding has been demonstrated on signals up to 3-GHz time-chip rate with 4/spl times/15 code words.
Tapir: Language Support to Reduce the State Space in Model-Checking. (2009)

Model-checking is a way of testing the correctness of concurrent programs. To do so, a model of the program is proven to match properties and constraints specified by the programmer. The model itself is created by disregarding irrelevant program details. The biggest problem in model-checking is the number of program states that need to be tested. Tapir, a simple but familiar object-oriented language and accompanying tool chain, addresses this problem in two ways. First, the programmer can provide application specific program transformations that reduce the state space. Second, for selected classes and methods, the programmer can provide an alternative implemen-tation: a slim black box version for use in model-checking that abstracts away many details of the full fledged implementation. Tapir’s aspect-oriented test case generation combined with black-boxing allows model-checking of low-level library code. 1
UVB irradiation-induced apoptosis increased in lymphocytes of Huntington's disease patients (2001)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansion in the IT-15 gene coding for huntingtin. The mechanism of neuronal degeneration induced by the mutant huntingtin is not known. Apoptosis may play a role in it. Huntingtin is widely expressed in the cells, so abnormalities can be expected also in non-neural tissue. We examined the susceptibility of lymphocytes from HD patients, asymptomatic carriers and normal individuals to UVB irradiation-induced apoptosis. Lymphocytes from eight HD patients and two asymptomatic carriers showed increased apoptotic cell death compared to controls. Our results suggests that sensitivity of HD cells to induced apoptosis is not restricted to neurons.
Opposite Self-Folding Behavior of Polymeric Photoresponsive Actuators Enabled by a Molecular Approach (2019)

The ability to obtain 3D polymeric objects by a 2D-to-3D shape-shifting method is very appealing for polymer integration with different materials, from metals in electronic devices to cells in biological studies. Such functional reshaping can be achieved through self-folding driven by a strain pattern designed into the molecular network. Among polymeric materials, liquid crystalline networks (LCNs) present an anisotropic molecular structure that can be exploited to tailor internal strain, resulting in a natural non-planar geometry when prepared in the form of flat films. In this article, we analyze the influence of different molecular parameters of the monomers on the spontaneous shape of the polymeric films and their deformation under different stimuli, such as heating or light irradiation. Modifying the alkilic chains of the crosslinkers is a simple and highly effective way to increase the temperature sensitivity of the final actuator, while modifying ester orientation on the aromatic core interestingly acts on the bending direction. Combining such effects, we have demonstrated that LCN stripes made of different monomeric mixtures originate complex non-symmetric deformation under light activation, thus opening up new applications in photonic and robotics.
Computation of fluid flow with multi-grid and multi-block algorithms (1959)

Computational Fluid Dynamics (CFD) has wide applications in areas such as aerospace, automobile and materials manufacturing industries. The development of CFD procedures has progressed extremely rapidly during the past two decades. However, the real world processes are usually too large and too complicated to simulate due to the computing and memory limits. The problems that are facing the computational fluid dynamicist can be briefly summarized as discretization and variable storing strategies, convergence acceleration of solution procedure, handling of complex geometries and turbulence modeling.&#13;\n&#13;\nIn the present study, an effort is made to develop solution procedures to tackle the above mentioned problems. The evaluation of the pressure field has always been the difficult issue in the primitive variable approach. To eliminate a wavy pressure field, the staggered grid approach was developed by Harlow and Welch (1965), but implementation of the staggered grid for a three-dimensional, curvilinear coordinate system is complicated and tiresome. In the present study, the results and convergence histories with using a solution procedure based on non-staggered grid system are reported and compared with that of staggered grid system. After comparing the flow field and convergence histories, the present non-staggered grid formulation proved as a potential alternative to staggered grid formulation. There has never been any pressure oscillation in this practice.
CD4 T Cells Are the Only Lymphocytes Needed To Protect Mice against Rotavirus Shedding after Intranasal Immunization with a Chimeric VP6 Protein and the Adjuvant LT(R192G) (2002)

Intranasal immunization of mice with a chimeric VP6 protein and the mucosal adjuvant Escherichia coli heat labile toxin LT(R192G) induces nearly complete protection against murine rotavirus (strain EDIM [epizootic diarrhea of infant mice virus]) shedding for at least 1 year. The aim of this study was to identify the protective lymphocytes elicited by this new vaccine candidate. Immunization of mouse strains lacking one or more lymphocyte populations revealed that protection was dependent on alphabeta T cells but mice lacking gammadelta T cells and B cells remained fully protected. Furthermore, depletion of CD8 T cells in immunized B-cell-deficient mice before challenge resulted in no loss of protection, while depletion of CD4 T cells caused complete loss of protection. Therefore, alphabeta CD4 T cells appeared to be the only lymphocytes required for protection. As confirmation, purified splenic T cells from immunized mice were intraperitoneally injected into Rag-2 mice chronically infected with EDIM. Transfer of 2 x 10(6) CD8 T cells had no effect on shedding, while transfer of 2 x 10(5) CD4 T cells fully resolved shedding in 7 days. Interestingly, transfer of naive splenic CD4 T cells also resolved shedding but more time and cells were required. Together, these results establish CD4 T cells as effectors of protection against rotavirus after intranasal immunization of mice with VP6 and LT(R192G).
On Learning the Energy Model of an MPSoC for Convex Optimization (2017)

The energy efficiency of a Multiprocessor SoC (MPSoC) is enhanced by complex hardware features such as Dynamic Voltage and Frequency Scaling (DVFS) and Dynamic Power Management (DPM). This paper proposes a methodology to learn an energy model from real power measurements. From this energy model, a convex optimization framework can determine the optimal energy efficient operating point in terms of frequency and number of active cores in an MPSoC. Experimental data are reported using a Samsung Exynos 5410 MPSoC. They show that a precise yet relatively simple model can be derived.
Pd-NHC (PEPPSI) Complexes: Synthetic Utility and Computational Studies into Their Reactivity (2008)

This review concentrates on the results obtained thus far in cross-coupling reactions utilising Pd-PEPPSI-IPr (pre)catalyst. Results from computational studies expose possible factors behind the high reactivity of this complex, as well as mechanistic details for the IPr-Pd-mediated alkyl-alkyl Negishi cross-coupling.