gebhart/patrepeval huggingface dataset:
From Coherent Systems Technology to Advanced Fiber Sensing for Smart Network Monitoring (2022)

Coherent technology developed in the past decade for transmission over core optical networks has leveraged the fiber capacity with the introduction of polarization diversity I/Q modulation along with advanced signal processing. Meanwhile, Distributed Acoustic Sensing (DAS) over telecom infrastructure has recently gained interest, and its introduction in deployed optical networks for in-depth supervision becomes a desirable feature for telecom operators. This paper intends to show that the combination of coherent solutions and digital processing techniques implemented today in current transceiver systems can strongly benefit DAS technology: key performance parameters as sensitivity threshold and sensing range, and coexistence with data traffic can be significantly improved compared with the figures achieved by initially introduced conventional solutions.
Physical Chemistry of Foods (2002)

Exploring the structure and physical and chemical properties of solutions, dispersions, soft solids, fats, and cellular systems, Physical Chemistry of Foods describes the physiochemical principles of the reactions and conversions that occur during the manufacture, handling, and storage of foods. Coverage progresses from aspects of thermodynamics, b
Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus (2021)

Epstein-Barr virus (EBV), a human herpesvirus, encodes 44 microRNAs (miRNAs), which regulate many genes with various functions in EBV-infected cells. Multiple target genes of the EBV miRNAs have been identified, some of which play important roles in adaptive antiviral immune responses. Using EBV mutant derivatives, we identified additional roles of viral miRNAs in governing versatile type I interferon (IFN) responses upon infection of human primary mature B cells. We also found that Epstein-Barr virus-encoded small RNAs (EBERs) and LF2, viral genes with previously reported functions in inducing or regulating IFN-I pathways, had negligible or even contrary effects on secreted IFN-α in our model. Data mining and Ago PAR-CLIP experiments uncovered more than a dozen previously uncharacterized, direct cellular targets of EBV miRNA associated with type I IFN pathways. We also identified indirect targets of EBV miRNAs in B cells, such as TRL7 and TLR9, in the prelatent phase of infection. The presence of epigenetically naive, non-CpG methylated viral DNA was essential to induce IFN-α secretion during EBV infection in a TLR9-dependent manner. In a newly established fusion assay, we verified that EBV virions enter a subset of plasmacytoid dendritic cells (pDCs) and determined that these infected pDCs are the primary producers of IFN-α in EBV-infected peripheral blood mononuclear cells. Our findings document that many EBV-encoded miRNAs regulate type I IFN response in newly EBV infected primary human B cells in the prelatent phase of infection and dampen the acute release of IFN-α in pDCs upon their encounter with EBV.<b>IMPORTANCE</b> Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that induce the transcription of IFN-I genes, the secretion of different IFN-I types and their recognition by the heterodimeric IFN-α/β receptor, the subsequent activation of JAK/STAT signaling pathways, and, finally, the transcription of many IFN-stimulated genes (ISGs). In sum, these cellular functions establish a so-called antiviral state in infected and neighboring cells. To counteract these cellular defense mechanisms, viruses have evolved diverse strategies and encode gene products that target antiviral responses. Among such immune-evasive factors are viral microRNAs (miRNAs) that can interfere with host gene expression. We discovered that multiple miRNAs of Epstein-Barr virus (EBV) control over a dozen cellular genes that contribute to the antiviral states of immune cells, specifically B cells and plasmacytoid dendritic cells (pDCs). We identified the viral DNA genome as the activator of IFN-α and question the role of abundant EBV EBERs, that, contrary to previous reports, do not have an apparent inducing function in the IFN-I pathway early after infection.
Multimodal Magneto‐Plasmonic Nanoclusters for Biomedical Applications (2014)

Multimodal nanostructures can help solve many problems in the biomedical field including sensitive molecular imaging, highly specific therapy, and early cancer detection. However, the synthesis of densely packed, multicomponent nanostructures with multimodal functionality represents a significant challenge. Here, a new type of hybrid magneto‐plasmonic nanoparticles is developed using an oil‐in‐water microemulsion method. The nanostructures are synthetized by self‐assembly of primary 6 nm iron oxide core‐gold shell particles resulting into densely packed spherical nanoclusters. The dense packing of primary particles does not change their superparamagnetic behavior; however, the close proximity of the constituent particles in the nanocluster leads to strong near‐infrared (NIR) plasmon resonances. The synthesis is optimized to eliminate nanocluster cytotoxicity. Immunotargeted nanoclusters are also developed using directional conjugation chemistry through the Fc antibody moiety, leaving the Fab antigen recognizing region available for targeting. Cancer cells labeled with immunotargeted nanoclusters produce a strong photoacoustic signal in the NIR that is optimum for tissue imaging. Furthermore, the labeled cells can be efficiently captured using an external magnetic field. The biocompatible magneto‐plasmonic nanoparticles can make a significant impact in development of point‐of‐care assays for detection of circulating tumor cells, as well as in cell therapy with magnetic cell guidance and imaging monitoring.
KIT genetic alterations in anorectal melanomas (2014)

The rate of functional mutations in KIT is significantly higher in AR MM than in GI metastatic melanoma. KIT protein overexpression does not correlate with KIT mutations and cannot be used for screening purposes. Recognising the molecular heterogeneity of MM helps to identify patients who require a different therapeutic approach.
Consider oxygen for hydrocarbon oxidations (1996)

A number of commodity petrochemicals are produced by the selective, catalytic oxidation of hydrocarbons in the liquid and gas phase. These chemicals are the basic building blocks for a host of chemical intermediates. Producing each of these chemicals requires large volumes of air or tonnage quantities of oxygen for oxidation. This oxidation can be carried out using air, oxygen-enriched air, or pure oxygen. Many oxidation processes, such as that for making ethylene oxide, originally were implemented using air but have switched to oxygen. Other processes, such as for vinyl acetate, were developed as oxygen-based processes directly. Over the years, using pure oxygen has become an accepted practice in a number of petrochemical processes, such as those for acetaldehyde, ethylene oxide, propylene oxide, vinyl acetate, and vinyl chloride. As the authors will discuss, using oxygen provides some significant advantages. So, the authors expect that the trend of existing air-based processes converting to oxygen will continue, while new processes based on oxygen will emerge.
Continual reproduction of self-assembling oligotriazole peptide nanomaterials (2017)

Autocatalytic chemical reactions, whereby a molecule is able to catalyze its own formation from a set of precursors, mimic nature's ability to generate identical copies of relevant biomolecules, and are thought to have been crucial for the origin of life. While several molecular autocatalysts have been previously reported, coupling autocatalytic behavior to macromolecular self-assembly has been challenging. Here, we report a non-enzymatic and chemoselective methodology capable of autocatalytically producing triskelion peptides that self-associate into spherical bioinspired nanostructures. Serial transfer experiments demonstrate that oligotriazole autocatalysis successfully leads to continual self-assembly of three-dimensional nanospheres. Triskelion-based spherical architectures offer an opportunity to organize biomolecules and chemical reactions in unique, nanoscale compartments. The use of peptide-based autocatalysts that are capable of self-assembly represents a promising method for the development of self-synthesizing biomaterials, and may shed light on understanding life's chemical origins.Molecules that act as both autocatalysts and material precursors offer exciting prospects for self-synthesizing materials. Here, the authors design a triazole peptide that self-replicates and then self-assembles into nanostructures, coupling autocatalytic and assembly pathways to realize a reproducing supramolecular system.
Clinical Presentation and Surgical Outcome in Patients With Solitary Rectal Ulcer Syndrome (2005)

Solitary rectal ulcer syndrome is a poorly understood clinical condition, and the schema of treatment has not yet been defined. This study reviewed the clinical spectra and outcome of various surgical treatments in patients with solitary rectal ulcer syndrome. The medical records of all patients with solitary rectal ulcer syndrome between 1992 and 1998 were retrospectively reviewed. Patients in the study population with symptoms and histopathologic findings suggestive of solitary rectal ulcer syndrome were placed in the primary solitary rectal ulcer syndrome group, and patients who underwent surgery for other diseases in whom histopathology confirmed concomitant solitary rectal ulcer syndrome were in the incidental group. Clinical features and outcomes of surgical treatment were documented. Improvement was considered as resolution of presenting symptoms, and non-improvement was considered if presenting symptoms persisted or worsened. The study cohort comprised 49 patients: 20 in the primary group and 29 in the incidental group. Ulcerative morphology was seen predominantly in the primary group (70%); erythematous (45%) and polypoid lesions (34%) were predominant in the incidental group (P = .0025). Clinical improvement after surgery was seen in 74% of patients with primary and 79% with incidental solitary rectal ulcer syndrome (P = NS). Manifestations such as tenesmus and digitation correlated with poorer outcome after surgery in both groups. Solitary rectal ulcer syndrome is a clinical condition associated with functional anorectal evacuatory disorders. The results of this study show the positive role of surgical treatment for underlying functional disorders in the improvement of incidental solitary rectal ulcer syndrome.
Dynamics of a semiflexible polymer poly(n‐hexyl isocyanate) in isotropic solution. 2. Dielectric dispersion (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Masafumi Asano, Hiroyuki Kusuoka, Atsuyuki Ohshima, Takahiro Sato, Akio Teramoto; Dynamics of a semiflexible polymer poly(n‐hexyl isocyanate) in isotropic solution. 2. Dielectric dispersion. J. Rheol. 1 July 1995; 39 (4): 800. https://doi.org/10.1122/1.550721 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Secure Compression and Pattern Matching Based on Burrows-Wheeler Transform (2018)

Searchable compressed data structures (e.g.Burrows-Wheeler Transform) enable one to create a memory-efficient index for large datasets such as human genomes. On the other hand, storing such an index in a third-party server, e.g., cloud, may have the privacy and confidentiality issues. An open problem in the community is to construct a secure variant of such a data structure. This problem is challenging as most of the existing works were shown to be insecure and none of them is able to perform pattern matching. In this paper, we provide the first solution based on Burrows-Wheeler Transform (BWT) to solve this problem (our scheme can do both compression and pattern matching). A new security definition, called isomophism-restricted IND-CPA security, is proposed. We show that our scheme is secure under this definition and our scheme is practical by experiments.
Modeling the helical flexoelectro-optic effect (2011)

The helical flexoelectro-optic effect shows interesting in-plane electro-optic switching behavior due to flexoelectric coupling with applied electric fields. Previous understanding of the behavior has been generally based on an analytic approach that makes certain assumptions about the uniformity of the helical structure and the induced tilt angle under field application. Here we remove these assumptions and develop a perturbative approximation to describe the structure in more detail. We also use a numerical method to investigate the behavior in regimes where the perturbative approach is inappropriate. The impact of variation in elastic constants and dielectric anisotropy is investigated. We find that dielectric behavior in particular can lead to substantial differences between the tilt angle obtained here and those obtained using previous analytic models.
Rejection of harmonic sensor disturbances in passive systems, and applications to attitude control (2006)

We consider the problem of asymptotic stabilization of nonlinear systems by output feedback, in the case in which the measured output is corrupted by additive harmonic noise. We restrict our attention to systems which are passive with respect to the measured output, and the sensor disturbance has a finite discrete spectrum. A simple condition for zero-state detectability of passive partially linear systems is derived, and the result is employed to analyze the loop interconnection resulting from the application of internal model-based controllers to the perturbed plant. The analysis applies directly to the problem of stabilizing the angular velocity and/ or regulating the attitude of a rigid body using noisy angular rate measurements. The proposed controllers have a simple structure that exploit the passivity property of both the internal model and the plant. Simulation results show the effectiveness of the design
Manejo sincrónico de la colecistocoledocolitiasis, ¿seguro? (2014)

Introducción. Existen diferentes abordajes terapéuticos para el manejo de los pacientes con diagnóstico o alta sospecha de colecistocoledocolitiasis. Estos incluyen procedimientos en uno o dos tiempos, que combinan las técnicas abiertas, laparoscópica y endoscópica. Se presenta nuestra experiencia con el manejo sincrónico –colangiopancreatografía retrógrada endoscópica más colecistectomía laparoscópica– de estos pacientes. Materiales y métodos. Se llevó a cabo un estudio descriptivo y retrospectivo en el cual se evaluó la seguridad del tratamiento de pacientes con alta sospecha o diagnóstico de colecistocoledocolitiasis, en quienes se practicaron procedimientos laparoscópico y endoscópico en un mismo tiempo quirúrgico, en el periodo comprendido entre octubre de 2008 y abril de 2012. Se utilizó estadística descriptiva y modelos de regresión logística, para el análisis de los datos recolectados. Resultados. En 105 pacientes se llevaron a cabo de forma exitosa ambos procedimientos. Requirieron conversión a cirugía abierta 15 pacientes (14,3 %). La morbilidad global fue del 18 %, representada por infecciones del sitio operatorio, sangrado, pancreatitis y coledocolitiasis residual. El promedio de duración del procedimiento fue de 109,5 minutos y el del tiempo de hospitalización fue de 4,7 días. No se presentaron muertes. Discusión. El manejo sincrónico de la colecistocoledocolitiasis es posible y seguro en nuestro medio. Su utilización depende de la disponibilidad del recurso técnico y humano. Hacen falta estudios comparativos que sustenten estos resultados.
Peroxide oxidation products of homocystine and lanthionine (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeroxide oxidation products of homocystine and lanthionineSamuel H. LiptonCite this: J. Agric. Food Chem. 1978, 26, 6, 1406–1409Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/jf60220a053https://doi.org/10.1021/jf60220a053research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanistic Studies of Octahydrophenazine Formation from a 2-Hydroxycyclohexanone/Ammonium Acetate Model System in Ethanol (1996)

Synopsis Model systems composed of 2-hydroxycyclohexanone and ammonium acetate in a mole ratio of 1 to 3 were set up to study the formation of octahydrophenazine (OHP). Octahydrophenazine and an intermediate were isolated and characterized by GC/MS (El and Cl). This intermediate was the condensation product between a molecule of 2-hydroxycyclohexanone and 2-amino-cyclohexanone via the SchifT base formation mechanism. A larger amount of the intermediate than of OHP was found in the solvent system containing less than 20% ethanol, the relative proportion of the intermediate decreasing as the percentage of ethanol was increased. The formation mechanism for OHP is proposed.
Respiratory‐induced vasoconstriction measured by light transmission and by laser Doppler signal (2012)

Changes in finger tissue blood volume (TBV) measured by light transmission and in laser Doppler flow (LDF) were obtained during long breathing (of 12 s period) and associated with the respiratory phases, inspiration and expiration. For fifteen out of sixteen subjects TBV and LDF started to decrease 0-2 s after the start of expiration and increased during inspiration but the start of increase occurred before the start of inspiration, showing that the respiratory-induced changes in TBV and LDF are mainly associated with the expiration. Decrease of TBV and LDF after expiration was also found during the inspiratory gasps
Passive calcium-buffering capacity of a rabbit ventricular homogenate preparation (1985)

This study characterizes the passive Ca2+-binding capacity of a crude homogenate fraction prepared from rabbit ventricular tissue. The soluble and particulate fractions of the homogenate were separated by centrifugation, and the Ca2+-binding capacity of each fraction was measured separately with Ca2+-selective electrodes and then summed to obtain the Ca2+-binding capacity of the total tissue homogenate. Qualitatively, the Ca2+ bound to the homogenate exhibited both relatively high- (Km less than 1 microM) and low-affinity (Km greater than 10 microM) sites over the physiological range of free Ca2+ concentrations. The total homogenate bound 72, 128, and 308 mumol Ca2+/kg wet wt tissue at 1, 10, and 50 microM free Ca2+ concentrations, respectively. The Ca2+ bound to the homogenate was mostly La3+ displaceable, which suggests that it represents a largely noncompartmentalized, rapidly exchangeable fraction of Ca2+. Myofibrillar ATPase activity was examined as a function of free Ca2+ concentration in an ionic medium similar to that used in the Ca2+-binding experiments. At free Ca2+ concentrations that stimulated myofibrillar ATPase activity half maximally, the measured rise in Ca2+ bound to the homogenate above resting values was greater than 100 mumol/kg wet wt. These data provide base-line values for the passive Ca2+-buffering capacity of the myocardium, although relevance to the physiological setting must be interpreted with caution.
[Closure of an atrial septal defect by a mini-thoracotomy with the help of extra-corporal circulation]. (2000)

Using a single venous cannula for drainage of both vena cavae simplifies the technique and therefore contributes to the development of "minimally invasive" cardiac surgery.
Pain Fellows Survey: COVID-19 Impact on the Training and Job Market (2021)

high-volume, single-injection ESPB provides effective analgesia compared to sham block" does not mean that "ESPB at the T2 level works as well as an interscalene block"; therefore, randomized controlled studies are needed to answer this question. As an answer to Shanthanna, I can say we have an ongoing study that compares ESPBs and interscalene blocks to a control group (ClinicalTrials.gov Identifier: NCT04083287). We will share our results as soon as possible when the study is completed.
The Connection Of Time Lapse Seismic To Geomechanics In A Study Off-Shore Brazil (2009)

Time lapse seismic has become increasingly important worldwide in recent years, not only as a method for seismic monitoring of mature reservoirs but as a tool that should be used at every phase of the reservoirs life time. Much of the worlds 4D seismic experience was previously concentrated in the North Sea, and many of the lessons learned in 4D originate from the extensive work that has been done there. In Brazil, although 4D seismic studies by Petrobras go back as far as 1998, the extension of the use of 4D in to the deep water environment, such as the 2005 Marlim project, poses both new challenges and opportunities for the Geophysical community. (See Figure 1) One challenge, for example, is to dtermine to exactly what extent it is possible to apply the concept of “repeatability” in the case where the ocean currents are far stronger and far less predictable than the case in the North Sea. An example of an opportunity is to attempt to link and interpret Geomechanical effects that are observed in producing fields, with the 4D signal extracted from time lapse seismic surveys. In this paper we look at the above challenges and opportunities and some recent work that has been done on this subject.
Lipase Production from Hydrocarbons byTrichosporon fermentansWU-C12 in the Presence of Surfactants (1994)

When Trichosporon fermentans WU-C12 was cultivated for 3–4 days in media containing 3% (v/v) kerosene and 0.8% (v/v) Tween 85, 3% (v/v) gas oil and 0.6% (v/v) Triton X-405, and 3% (v/v) liquid paraffin and 0.6% (v/v) Span 80, the extracellular lipase activities reached 58–62 U/ml, approximately 2–3 times as much as that without any addition of surfactant. The extracellular and total (intra-plus extracellular) lipase activities were affected by the combination of surfactants and petroleum products as the carbon sources.