gebhart/patrepeval huggingface dataset:
Current Progress on Neuroprotection Induced by Artemisia, Ginseng, Astragalus, and Ginkgo Traditional Chinese Medicines for the Therapy of Alzheimer’s Disease (2022)

Aging is associated with the occurrence of diverse degenerative changes in various tissues and organs and with an increased incidence of neurological disorders, especially neurodegenerative diseases such as Alzheimer's disease (AD). In recent years, the search for effective components derived from medicinal plants in delaying aging and preventing and treating neurodegenerative diseases has been increasing and the number of related publications shows a rising trend. Here, we present a concise, updated review on the preclinical and clinical research progress in the assessment of the therapeutic potential of different traditional Chinese medicines and derived active ingredients and their effect on the signaling pathways involved in AD neuroprotection. Recognized by their multitargeting ability, these natural compounds hold great potential in developing novel drugs for AD.
Synthesis of α-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction (2016)

α-Sulfenyl ketones are potential precursors which find a variety of applications in organic synthesis. Their typical synthesis requires pre-functionalized starting materials and two to three step synthetic sequences. In addition, the selective pre-functionalization of unsymmetrical ketones is a challenge, which limits the synthesis of the desired sulfenylated ketones. To overcome these disadvantages, a metal-free, convenient one-step strategy for synthesizing α-sulfenyl ketones at ambient temperature via a cross-dehydrogenative coupling (CDC) strategy has been developed with a broad substrate scope. Therefore, this CDC strategy for C-S bond formation is attractive and may find wide applications in organic synthesis.
Linkage and association analysis of candidate genes in rheumatoid arthritis. (2001)

Our results do not provide evidence of a role for these genes in RA susceptibility.
Live two-photon imaging reveals distinct contribution of neutrophilic and stromal Toll-like receptor 4 in hyper-acute bone marrow response to systemic lipopolysaccharide insult (INC5P.324) (2014)

Abstract Produced in the bone marrow (BM) in large quantities, neutrophils are rapidly mobilized and released into circulation in response to inflammation and infection. How BM neutrophils are released as a result of CXCL12 and CXCL1/CXCL2 gradients have been studied at a long time scale (hours to days) following lipopolysaccharide (LPS) challenge. However, little is known about how neutrophil and BM stroma react during the hyper-acute (minutes to hours) phase. We performed intravital microscopy on mice that express GFP under the Lysozyme M (LysM) promoter. BM chimeras were generated to differentiate TLR4-mediated responses in hematopoietic and radio-resistant stroma. We observed a 2.5-fold increase in the speed and the formation of dynamic cellular clusters in 50% of BM neutrophils 30-60 minutes after LPS injection. The neutrophils achieved a peak average speed of 8.4 um/min, accompanied by their disappearance into circulation as evidenced by a 40% reduction in the GFP fluorescence after 90 minutes. BM chimera experiments revealed that while intra-marrow migration and cellular clustering are dependent on TLR4 signaling in neutrophils, their release into systemic circulation is dependent on stromal TLR4 signaling. Blocking CXCR2 signaling had the same effect as chimeras expressing TLR4-defective stroma, further revealing that BM stroma modulate TLR4-mediated neutrophil mobilization and release via CXCL1/CXCL2 chemokine signaling during the hyper-acute phase of marrow response to LPS.
FECUNDITY OF MELANOPLUS SANGUINIPES (F.) IN TWO CRESTED WHEATGRASS PASTURES (1988)

Abstract Oviposition rate (eggs per ♀-degree-day) and fecundity (total number of eggs per ♀) were measured in two populations of Melanoplus sanguinipes (F.) under natural conditions during two seasons (1984, 1985). Differences in fecundity between the two seasons were indirectly associated with differences in time of hatching. In 1985, females hatched earlier and had shorter preoviposition periods, greater longevities, and higher oviposition rates; consequently, fecundity averaged about three-fold greater than in 1984. Longevity appeared to be the most important single determinant of fecundity. Maximum fecundity was 73.2 eggs (equivalent to four pods) and mean fecundity ranged between 10.1 and 28.9 eggs per female.
Biology and functions of human leukocyte antigen‐G in health and sickness* (2003)

In 1998, the first International Conference on human leukocyte antigen-G (HLA-G) was held in Paris. At that time, HLA-G was still a new HLA class I molecule, few aspects of its immunological functions were known, and its expression by tumors was just being described. In 1998, tools to properly study HLA-G were lacking, especially monoclonal antibodies, and three conclusions were drawn after the congress: (i) animal models were needed, (ii) the biology of HLA-G isoforms had to be confirmed, and (iii) HLA-G expression by tumors required clarification. Five years later, these three issues have been addressed. HLA-G is now gaining pace and is investigated for its immuno-inhibitory functions in the context of multiple pathologies. Eighty five oral presentations were given this year for more than 200 investigators working on HLA-G by speakers from over 20 countries. The success of the 3rd International Conference on HLA-G reflects the interest and tremendous work of the many research teams which, over the years, contributed to the publication of more than 500 peer-review articles. We summarize the key points that were presented and discussed during this meeting.
Unsupervised segmentation of colored texture images by using multiple GMRF models and a hypothesis of merging primitives (2000)

Images of outdoor scenes involve many textured areas. In terms of coding and recognition, it is important to extract textured areas using not only color but also various texture features. Texture features are represented at segment level rather than by individual pixels, hence it is difficult to use such features near area boundaries. In this study, Gaussian Markov random field modeling is employed with multiple independent parameters. In so doing, preprocessing is performed to minimize correlation among color planes, and GMRF parameters are estimated using hypothetical merging, so that texture features can be used near segment boundaries as well. As merged segments grow in size, more precise GMRF models are used which results in images with smooth boundaries. © 2000 Scripta Technica, Syst Comp Jpn, 31(2): 29–39, 2000
General Route to Homogeneous, Mesoporous, Multicomponent Oxides Based on the Thermolytic Transformation of Molecular Precursors in Non-polar Media (2001)

Mesoporous mixed-element oxides have proved difficult to synthesize via the surfactant template method that has been applied so successfully to silica. A synthetic strategy based on the use of molecular precursors in conjunction with block copolymer templates is revealed here for the production of homogeneous multi-component oxides (see Figure).
Surface Modification of CdSe Nanocrystals with Organic Ligands (2002)

Every solid particle has adsorbed molecules on its surface under atmospheric conditions. This interface is particularly important when a system is composed of nanoparticles thus change of optical properties can directly be observed.
Prospective randomized trial of piperacillin monotherapy versus carboxypenicillin-aminoglycoside combination regimens in the empirical treatment of serious bacterial infections (1983)

Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference in the clinical response rates with piperacillin (77% of 26 infection episodes) and combination therapy (75% of 24 infection episodes) were not statistically significant. Fewer adverse effects occurred in the piperacillin-treated group (42%) than in the combination-treated group (71%) (P = 0.0399 by Fisher's exact test), although neither nephrotoxicity nor hypokalemia alone was significantly less frequent in patients receiving piperacillin. However, the emergence of resistant organisms during therapy was more frequent among patients receiving piperacillin alone (42% of patients) than among patients receiving combination therapy (17% of patients) (P = 0.465 by Fisher's exact test). Moreover, emergence of resistance accounted for 5 of 9 patients with treatment failure, superinfection, or both when piperacillin was used as a single agent, compared with 2 of 10 similar patients in the combination group (P = 0.1299 by Fisher's exact test). The use of piperacillin as a single agent in the treatment of serious bacterial infections is not advocated, and the addition of an aminoglycoside to prevent emergence of resistance during empirical therapy of such infections is strongly recommended.
Qur&rsquo;anic insights into sleep (2012)

Sleep has preoccupied and fascinated many civilizations since the dawn of mankind. Here, we critically review the various elements pertaining to sleep in the context of early Islamic religion and culture. The many principles of sleep hygiene, wellbeing and health associated with adequate sleep, and the understanding of sleep as a dynamic state are all apparent from such explorative process of Islamic tradition.
Adaptive channel equalization using the sign regressor least mean fourth algorithm (2011)

In this paper, the performance analysis of the least mean fourth (LMF) algorithm and the sign regressor least mean fourth (SRLMF) algorithm is investigated in an adaptive channel equalization scenario. The simulation results indicate that both the LMF and the SRLMF algorithms exhibit similar bit error rate (BER) performance. Moreover, the results show that the SRLMF algorithm has a slight performance degradation in terms of convergence behavior when compared with the LMF algorithm.
Data from BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; This study examined the potential role of the nuclear deubiquitinating enzyme BRCA1-associated protein-1 (BAP1) in radioresistance in head and neck squamous cell cancer (HNSCC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We overexpressed, knocked down, and rescued BAP1 expression in six HNSCC cell lines, three human papillomavirus (HPV)–negative and three HPV-positive, and examined the effects on radiosensitivity &lt;i&gt;in vitro&lt;/i&gt; and in an HNSCC mouse xenograft model. Radiosensitivity was assessed by clonogenic cell survival and tumor growth delay assays; changes in protein expression were analyzed by immunofluorescence staining and Western blotting. We also analyzed The Cancer Genome Atlas HNSCC database to test for associations between BAP1 expression and outcome in patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Overexpression of BAP1 induced radioresistance in both cell lines and xenograft models; conversely, BAP1 knockdown led to increased ubiquitination of histone H2A, which has been implicated in DNA repair. We further found that BAP1 depletion suppressed the assembly of constitutive BRCA1 foci, which are associated with homologous recombination (HR), but had minimal effect on γ-H2AX foci and did not affect proteins associated with nonhomologous end joining, suggesting that BAP1 affects radiosensitivity in HNSCC by modifying HR. Finally, in patients with HNSCC, overexpression of BAP1 was associated with higher failure rates after radiotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; BAP1 can induce radioresistance in HNSCC cells, possibly via deubiquitination of H2Aub and modulation of HR, and was associated with poor outcomes in patients with HNSCC. BAP1 may be a potential therapeutic target in HNSCC. &lt;i&gt;Clin Cancer Res; 24(3); 600–7. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Comparison and Design of Resonant Network Considering the Characteristics of a Plasma Generator (2019)

This paper presents a theoretical analysis and experimental study on the resonant network of the power conditioning system (PCS) for a plasma generator. In order to consider the characteristics of the plasma load, the resonant network of the DC-AC inverter is designed and analyzed. Specifically, the design of an LCL resonant network and an LCCL resonant network, which can satisfy the output current specification in consideration of plasma characteristics, is explained in detail. Moreover, the inverter current and phase angle between the inverter voltage and current is derived for evaluating inverter performance. Based on these analysis results, the DC-AC inverter can be designed for a plasma generator considering plasma load characteristics. The theoretical analysis of both networks is validated through the simulation and experimental results.
Characterisation and transplantation of enteric nervous system progenitor cells (2006)

We have developed a technique for the isolation and expansion of ENS progenitor cells from human neonates. These cells have the ability to differentiate into neurons and glia when transplanted into aganglionic gut, this demonstration being a necessary first step for their autologous transplantation in the treatment of Hirschsprung's disease.
The 5′ Untranslated Region of the EFG1 Transcript Promotes Its Translation To Regulate Hyphal Morphogenesis in Candida albicans (2018)

Many of the virulence traits that make Candida albicans an important human fungal pathogen are regulated on a transcriptional level. Here, we report an important regulatory contribution of translation, which is exerted by the extensive 5′ untranslated regulatory sequence (5′ UTR) of the transcript for the protein Efg1, which determines growth, metabolism, and filamentation in the fungus. The presence of the 5′ UTR is required for efficient translation of Efg1, to promote filamentation. Because transcripts for many relevant regulators contain extensive 5′ UTR sequences, it appears that the virulence of C. albicans depends on the combination of transcriptional and translational regulatory mechanisms.
Bush Fire Recommendations - to Be Implemented 'Lock Stock and Barrel'? (2011)

The final report of the Bushfire Royal Commission was tabled in Parliament one year ago on 31 July 2010. Now the response to the devastating bush fires of February 2009 in which 173 Victorians lost their lives should be moving to the next stage - implementation of the recommendations.
Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term (2020)

We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB) and term birth. A secondary analysis of a multi-center, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 336/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonray dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8% and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term (p< 0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared to twins born at term.
Fabrication of Polymer Neural Probes with Sub-cellular Features for Reduced Tissue Encapsulation (2006)

Intracortical microelectrodes currently have great potential as a neural prosthesis in patients with neurodegenerative disease or spinal cord injury. In an effort to improve the consistency of neural probe performance, many modifications to probe design are focused on reducing the tissue encapsulation. Since researchers have shown that small polymer fibers (less than 7-mum diameter) induce a small to non-existent encapsulation layer in the rat subcutis, we have proposed a neural probe design with similarly small diameter structures. This paper discusses the fabrication and design parameters of a microscale neural probe with a sub-cellular lattice structure. We developed a microfabrication process using SU-8 and parylene-C to create the relatively thick probe shank and thin lateral arms. The stiff penetrating shank (70-mum by 42-mum) had an SU-8 core that allowed control over stiffness and simplified the process. Parylene-only structures lateral to the shank could be defined with a 4-mum feature-size to meet our sub-cellular criterion. We fabricated four varying geometries for implantation into the neocortex of seven Sprague-Dawley rats. Our in vivo testing verifies that despite the flexible substrate and small dimensions (4-mumtimes5-mum), these devices are mechanically robust and practical as neural probes. These devices provide an important tool for neural engineers to investigate the tissue response around sub-cellular structures and potentially improve device efficacy
Fluorescent Diarylindoles by Palladium‐Catalyzed Direct and Decarboxylative Arylations of Carboxyindoles (2009)

Simple and brilliant: 1-Substituted 1H-indole-2-carboxylic acids efficiently undergo successive diarylation accompanied by C-H bond cleavage and decarboxylation upon treatment with aryl bromides in the presence of a palladium catalyst system to afford fluorescent 2,3-diarylindoles. This facile synthetic method provides a highly efficient blue emitter with a quantum yield of 0.97 in the solid state (see scheme).
Wittig‐Synthese und Röntgen‐Struktur eines 26‐gliedrigen, zwei Bipyridin‐Einheiten enthaltenden Makrocyclus (1990)

Wittig Synthesis and X‐Ray Structure of a 26‐Membered Macrocycle Containing two Bipyridine Units Wittig‐type macrocyclization of bipyridinedicarbaldehyde 5 with bis(phosphonium bromide) 6 leads to the new bipyridinophanes 7 8 . The X‐ray structural analysis of 8 reveals a step‐type conformation, which according to 1 H‐NMR results is also present in solution.
Transform-limited single photons from a single quantum dot (2015)

Developing a quantum photonics network requires a source of very-high-fidelity single photons. An outstanding challenge is to produce a transform-limited single-photon emitter to guarantee that single photons emitted far apart in the time domain are truly indistinguishable. This is particularly difficult in the solid-state as the complex environment is the source of noise over a wide bandwidth. A quantum dot is a robust, fast, bright and narrow-linewidth emitter of single photons; layer-by-layer growth and subsequent nano-fabrication allow the electronic and photonic states to be engineered. This represents a set of features not shared by any other emitter but transform-limited linewidths have been elusive. Here, we report transform-limited linewidths measured on second timescales, primarily on the neutral exciton but also on the charged exciton close to saturation. The key feature is control of the nuclear spins, which dominate the exciton dephasing via the Overhauser field.
Design and Implementation of Ultra Wideband Antenna with Resistive Loading (2006)

Broadband antennas have late-time ringing by multi-reflections between feed points and 0pen ends of the antennas, which indicates the narrowband nature of the antenna. The resistive loading has been used to reduce the late time ringing that is important for ground penetrating radar and resonance detection systems in order to prevent masking of target. In this paper, we design an ultra wide band antenna with resistive loading technique to reduce the internal reflections within the antenna.. The designed antenna is implemented and tested to show inIproved characteristics
59. Development of Conditionally Replicative Adenoviruses as Platforms for the Expression of shRNAs or Therapeutic Genes (2004)

Conditionally replicative adenoviruses (CRAds) represent a novel class of anticancer agents, designed to selectively replicate in tumor cells and to destroy these cells by the induction of lysis. We aim to enhance CRAd oncolytic potency by suppressing apoptosis inhibitors or by expressing toxic proteins in CRAd-infected cancer cells. Towards the first goal, we explored the utility of RNA interference (RNAi) in the context of CRAd replication in cancer cells. RNAi is the sequence-specific gene-silencing induced by double-stranded RNA (dsRNA) and is now widely used to study the function of individual genes. By virtue of its excellent target specificity, RNAi also holds great promise as a new anticancer modality. The success of this approach largely depends on efficient delivery of dsRNA to tumor cells. As a proof of principle, we constructed CRAds encoding short hairpin RNAs (shRNAs) targeted against firefly luciferase and assessed their silencing efficiency. These replicating viruses silenced firefly luciferase expression relative to control virus in the four human cancer cell lines tested. In a time course experiment, the expression inhibition was especially evident during later stages of infection, reaching a maximum of approximately 70% silencing at the time when CPE became apparent. The CRAd-shRNA induced silencing was not observed in an experiment using a reporter plasmid with point mutations in the target site of the shRNA, confirming the sequence-specificity of the silencing effect. Thus, successful RNAi was accomplished.
Control configuration selection for economic model predictive control (2014)

Economic model predictive control (EMPC) is a control scheme that dictates a potentially dynamic operating policy to optimize the process economics. The objective function used in the EMPC may be a general nonlinear function that describes the process/system economics. Since this function is not derived on the basis of classical control considerations only (e.g., stabilization, tracking, and optimal control action calculation), selecting the appropriate control configuration and quantifying the influence of a given input on an economic cost is an important task for the proper design of an EMPC scheme. Owing to these considerations, we propose to utilize the relative degree of the economic cost function with respect to an input to identify and select inputs with the most influence on the economic cost function to be assigned to EMPC. Other considerations for input selection for EMPC are also discussed and the presented control configuration selection for EMPC method is demonstrated using a chemical process example.