gebhart/patrepeval huggingface dataset:
Automated methods for data-driven synthesis of realistic and controllable human motion (2004)

Human motion is difficult to animate convincingly—not only is the motion itself intrinsically complicated, but human observers have a lifetime of familiarity with human movement, which makes it easy to detect even minor flaws in animated motion. To create high-fidelity animations of humans, there has been growing interest in motion capture, a technology that obtains strikingly realistic 3D recordings of the movement of a live performer. However, by itself motion capture offers little control to an animator, as it only allows one to play back what has been recorded. This dissertation shows how to use motion capture data to build generative models that can synthesize new, realistic motion while providing animators with high-level control over the properties of this motion. In contrast to previous work, this dissertation focuses on automated algorithms that make it feasible to work with the large data sets that are needed to construct expressive motion models. Two models in particular are considered. The first is the motion graph, which allows one to rearrange and seamlessly attach short motion segments into longer streams of movement. The second is motion blending, which creates motions “in between” a set of examples and can be used to create continuous and intuitively parameterized spaces of related actions. Automated methods are presented for building these models and for using them to generate realistic motion that satisfies high-level requirements.
Performance evaluation of advanced spectrum functionalities for future radio networks (2008)

Abstract This paper presents novel spectral resource management (SRM) functionalities of WINNER ‡ The WINNER project is a major European research activity to develop a flexible and scalable radio access interface for future wireless communication systems. project. The proposed SRM spectrum architecture uses more efficient resource allocation techniques where flexible spectrum access and usage leads to more capable and faster services with high quality‐of‐service (QoS) giving more user satisfaction than conventional networks. In this context, short‐term (ST) spectrum assignment is proposed where spectral resources are exchanged between WINNER radio access networks (RANs) on a fast basis, leading to a better utilization of the spectrum. Moreover, multi‐band scheduler (MBS) and base station (BS) to BS communications are presented as key enablers for efficient dynamic spectrum management. Performance gains of ST spectrum assignment are analyzed in a multi‐network, multi‐cell environment based on realistic traffic patterns while taking inter‐cell interference into account. The results confirm that spectrum availability and utilization can be considerably enhanced. Copyright © 2008 John Wiley &amp; Sons, Ltd.
Abstract 13411: Overexpression of Interleukin-10 in Murine Macrophages for Anti-Inflammatory Therapy in Myocarditis (2010)

Objectives: Myocarditis is a multifactorial disease and macrophages play an essential role in the pathogenesis of myocardial inflammation. A specific and approved therapy is often missing or limite...
In Memoriam: Peter J. Van Soest (1929–2021) (2022)

Peter J. Van Soest, one of the most influential animal scientists and professors of his generation, died March 21, 2021. Van Soest (pronounced “Van Soost”) was born June 30, 1929, and grew up on a dairy farm in Snohomish, Washington. He graduated from the Department of Dairy Science of Washington State University with a BS in 1951, and a MS in 1952. He said that his minor in physical chemistry gave him a new way of looking at the world. He obtained his PhD in the Department of Dairy Husbandry at the University of Wisconsin in 1955 and was drafted into the Army where he served as a biochemist at Walter Reed Army Institute of Research, working on analysis of minerals in blood.
Splenic irradiation for patients with polycythemia vera (1995)

Abstract Seven patients with a diagnosis of polycythemia vera (PCV) with symptomatic splenomegaly received 10 courses of splenic irradiation. Patients received a total dose of 250–1,425 cGy to the whole spleen with twice‐weekly fractionation beginning with 25 cGy per fraction, gradually escalating to no more than 100 cGy per fraction. All 10 courses resulted in palliation of the symptoms of abdominal discomfort and early satiety. Greater than 50% reduction in spleen size was observed in 7 of 10 courses. The primary toxicity was a transient decrease in circulating platelets though two patients with thrombocytopenia at presentation had improvement in their platelet counts corresponding with a decrease in spleen size. These results demonstrate that splenic irradiation with low dose, twice‐weekly irradiation is an effective way to reduce spleen size and palliate symptoms in patients with PCV. © 1995 Wiley‐Liss, Inc.
Preparation and degradation of head‐to‐head PVC (1978)

Abstract The course of the chlorination reaction of cis ‐1,4‐polybutadiene is dependent on the choice of solvent. When methylene chloride is used, a pure addition reaction of chlorine leads to a polymer with the structure of head‐to‐head, tail‐to‐tail PVC. The thermal stability of the head‐to‐head PVC polymer has been studied by thermal volatilization analysis, thermogravimetry, and evolved gas analysis for hydrogen chloride, and the changes in the ultraviolet (UV) spectrum of the polymer during degradation have been investigated. The head‐to‐head polymer has a lower threshold temperature of degradation than normal PVC, but reaches its maximum rate of degradation at a higher temperature for powder samples of the polymer under programmed heating conditions. Blends of head‐to‐head PVC with poly(methyl methacrylate) have also been degraded, and the presence of the head‐to‐head polymers, like that of normal PVC, results in depolymerization of the PMMA as soon as the dehydrochlorination reaction commences. The mechanism of degradation of head‐to‐head PVC is discussed.
Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population (2022)

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_02_08_CJN09070822.mp3.
Identification of Proteins Cleaved Downstream of Caspase Activation in Monocytes Undergoing Macrophage Differentiation (2006)

We have shown previously that caspases were specifically involved in the differentiation of peripheral blood monocytes into macrophages while not required for monocyte differentiation into dendritic cells. To identify caspase targets in monocytes undergoing macrophagic differentiation, we used the human monocytic leukemic cell line U937, whose macrophagic differentiation induced by exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) can be prevented by expression of the baculovirus caspase-inhibitory protein p35. A comparative two-dimensional gel proteomic analysis of empty vector- and p35-transfected cells after 12 h of exposure to 20 nm TPA, followed by mass spectrometry analysis, identified 38 differentially expressed proteins. Those overexpressed in p35-expressing cells (n = 16) were all full-length, whereas half of those overexpressed in control cells (n = 22) were N- or C-terminal cleavage fragments. The cleavage or degradation of seven of these proteins was confirmed in peripheral blood monocytes undergoing macrophage colony-stimulating factor-induced macrophagic differentiation. In U937 cells exposed to TPA, these proteolytic events can be inhibited by expression of a caspase-8 dominant negative mutant or the cowpox virus CrmA caspase inhibitor. These cleavages provide new insights to analyze the role of caspases in this specific differentiation program.
Effects of Elamipretide in Adults with Primary Mitochondrial Myopathy: a Phase 2 Double-Blind, Randomized, Placebo-Controlled Crossover Trial (MMPOWER-2) (S5.003) (2018)

In MMPOWER, a study of patients with genetically confirmed Primary Mitochondrial Myopathy (PMM), intravenous elamipretide (ELAM) for five days increased the distance walked versus placebo during the 6-Minute Walk Test (6MWT) in a dose dependent fashion. The current study (MMPOWER-2) evaluated the effect of 4-weeks of subcutaneous ELAM on several functional and patient-reported assessments.
A Multichip Neuromorphic System for Spike-Based Visual Information Processing (2007)

We present a multichip, mixed-signal VLSI system for spike-based vision processing. The system consists of an 80 x 60 pixel neuromorphic retina and a 4800 neuron silicon cortex with 4,194,304 synapses. Its functionality is illustrated with experimental data on multiple components of an attention-based hierarchical model of cortical object recognition, including feature coding, salience detection, and foveation. This model exploits arbitrary and reconfigurable connectivity between cells in the multichip architecture, achieved by asynchronously routing neural spike events within and between chips according to a memory-based look-up table. Synaptic parameters, including conductance and reversal potential, are also stored in memory and are used to dynamically configure synapse circuits within the silicon neurons.
Earthen building in Tuscany: characterization of the material used in buildings in the high Valdarno (1995)

Results are reported of mechanical tests performed on earth material already used for country buildings.
Real-time APL prototype of a GPS system (1996)

The Global Positioning System (GPS) consists of a constellation of 24 high-altitude satellites with very accurate atomic clocks, along with a global network of satellite tracking stations and sophisticated ground processing stations, that together provide precise navigation coordinates to any user who possesses a small, readily available GPS receiver.The precision that is achieved depends on[1] the number of GPS satellites in view of the user and the geometries involved;[2] the design of the user's receiver (e.g., military or civilian);[3] the presence of nearby objects that may interfere with or degrade the reception of signals from one or more satellites;[4] and other factors.In most cases civilian users (whose receivers can read only unencrypted, intentionally corrupted GPS signals) can expect navigation accuracy on the order of 50-100 meters. The advertised accuracy for users with military receivers, which read the encrypted GPS signals, is 16 meters. Coalition forces in Desert Shield / Desert Storm relied heavily on GPS, and U.S. military authorities praised GPS effusively for its effectiveness as a force multiplier in that conflict.Loral Federal Systems (formerly IBM Federal Systems Division) in Gaithersburg, Maryland has been intimately involved with GPS from its concept validation phase through operations and maintenance. People in this group analyzed the physical dynamics, designed the mathematical algorithms and associated software, and performed the system integration work that culminated in the GPS ground control segment.APL was used over the years in most major aspects of GPS design and analysis. Early in the full-scale development phase, APL was used to model the initial GPS system design, to perform design tradeoffs, to model and test candidate algorithms, and to perform error analyses to estimate future system performance. In later phases APL was used to monitor and analyze actual GPS system performance, to compare it with theoretically achievable performance, and to analyze and isolate anomalies [Allan].
A highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediation reaction (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediation reactionToshiro Ibuka, Hiromu Habashita, Akira Otaka, Nobutaka Fujii, Yusaku Oguchi, Tadao Uyehara, and Yoshinori YamamotoCite this: J. Org. Chem. 1991, 56, 14, 4370–4382Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a010https://doi.org/10.1021/jo00014a010research-articleACS PublicationsRequest reuse permissionsArticle Views818Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multicriteria methodology and hierarchical innovation in the energy sector (2018)

Purpose The purpose of this paper is to state a hierarchy methodology to select the most promising innovative projects, based on the processes defined by the successful Project Management Institute. Design/methodology/approach Open innovation is a new option for companies to acquire knowledge; however, in a changing and global market, it is necessary to define and select properly the proposals to be financially supported. A proven multicriteria decision methodology (MCDM) is recommended in this case to hierarchize alternatives. Moreover, analytical hierarchy process (AHP) has been considered in this study as a proven and simple MCDM. Findings AHP has been demonstrated as a suitable option to evaluate innovative project proposals, thanks to its integration with the Project Management Institute methodology. A process example has been included to demonstrate its application. Research limitations/implications Innovative projects and project proposal selection have always implied subjective criteria. Moreover, some of the processes defined in the methodology were not well defined in the project proposal. Practical implications The management of a project portfolio in a rational way would help decision makers to fund the most promising projects/alternatives under consideration. In this way, the inherent risk of R&amp;D projects would be minimized. Originality/value The management of a portfolio of innovative proposals is less often addressed in the literature. This paper focuses on the hybridization of the criteria and processes described in the PMBOK Guide and an MCDM.
EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics (2019)

<b>Background:</b> Chronic vagal nerve stimulation (VNS) is a well-established non-pharmacological treatment option for drug-resistant epilepsy. This study sought to develop a statistical model for prediction of VNS efficacy. We hypothesized that reactivity of the electroencephalogram (EEG) to external stimuli measured during routine preoperative evaluation differs between VNS responders and non-responders. <b>Materials and Methods:</b> Power spectral analyses were computed retrospectively on pre-operative EEG recordings from 60 epileptic patients with VNS. Thirty five responders and 25 non-responders were compared on the relative power values in four standard frequency bands and eight conditions of clinical assessment-eyes opening/closing, photic stimulation, and hyperventilation. Using logistic regression, groups of electrodes within anatomical areas identified as maximally discriminative by <i>n</i> leave-one-out iterations were used to classify patients. The reliability of the predictive model was verified with an independent data-set from 22 additional patients. <b>Results:</b> Power spectral analyses revealed significant differences in EEG reactivity between responders and non-responders; specifically, the dynamics of alpha and gamma activity strongly reflected VNS efficacy. Using individual EEG reactivity to develop and validate a predictive model, we discriminated between responders and non-responders with 86% accuracy, 83% sensitivity, and 90% specificity. <b>Conclusion:</b> We present a new statistical model with which EEG reactivity to external stimuli during routine presurgical evaluation can be seen as a promising avenue for the identification of patients with favorable VNS outcome. This novel method for the prediction of VNS efficacy might represent a breakthrough in the management of drug-resistant epilepsy, with wide-reaching medical and economic implications.
Transmit Antenna Selection OFDM Systems With Transceiver I/Q Imbalance (2011)

One of the serious imperfections affecting orthogonal frequency-division multiplexing (OFDM) systems is transceiver in-phase/quadrature-phase (I/Q) imbalance. In this paper, the effect of I/Q imbalances on the transmit antenna selection (TAS) OFDM system is studied. The optimum antenna selection in presence of transmit and receive I/Q imbalances are proposed. We derive closed-form expressions for ergodic capacity of the system with transmit and receive I/Q imbalances. Moreover, some tight and simple lower and upper bounds for the ergodic capacity of the TAS OFDM system are derived. The simplicity of the proposed formula gives insight into the performance and optimization of the system. Finally, the analytical results are confirmed by simulations.
Antrodin C Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Suppression of Smad2/3 and β-Catenin Signaling Pathways (2015)

Epithelial-to-mesenchymal transition (EMT) is a crucial event involved metastasis of certain tumors. Thus, identifying chemical agents that can block EMT is highly warranted for the development of anti-cancer chemoprevention/chemotherapies. In this study, we found that Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea health food product inhibits TGF-β1-induced EMT and breast cancer cell metastasis in vitro. Pretreatment of MCF-7 cells with ADC significantly blocked TGF-β1-induced phenotypic changes and actin cytoskeleton remodeling. In addition, ADC was able to up-regulate epithelial markers such as E-cadherin and occludin, whereas mesenchymal markers including N-cadherin and vimentin were significantly inhibited, possibly through the modulation of transcriptional regulators Smad/Smad3. ADC blocked TGF-β1-induced migration and invasion of MCF-7 cells through the down-regulation of matrix-metalloproteinases (MMP-2, -9) and urokinase plasminogen activator (uPA). The inhibition of MMPs and uPA activity by ADC was reasoned by suppression of its corresponding transcription factor β-catenin. Taken together, our data suggested that ADC attenuates the TGF-β1-induced EMT, migration and invasion of human breast carcinoma through the suppression of Smad2/3 and β-catenin signaling pathways.
Evaporation mitigation by floating modular devices (2016)

Prolonged periods of drought and consequent evaporation from open water bodies in arid parts of Australia continue to be a threat to water availability for agricultural production. Over many parts of Australia, the annual average evaporation exceeds the annual precipitation by more than 5 times. Given its significance, it is surprising that no evaporation mitigation technique has gained widespread adoption to date. High capital and maintenance costs of manufactured products are a significant barrier to implementation. The use of directly recycled clean plastic containers as floating modular devices to mitigate evaporation has been investigated for the first time. A six-month trial at an arid zone site in Australia of this potential cost effective solution has been undertaken. The experiment was performed using clean conventional drinking water bottles as floating modules on the open water surface of 240-L tanks with three varying degrees of covering (nil, 34% and 68%). A systematic reduction in evaporation is demonstrated during the whole study period that is approximately linearly proportional to the covered surface. These results provide a potential foundation for robust evaporation mitigation with the prospect of implementing a cost-optimal design.
Dissolution of Microcrystalline Cellulose in Phosphoric Acid—Molecular Changes and Kinetics (2009)

In this study, we aimed to dissolve microcrystalline cellulose (MCC) with phosphoric acid to obtain high-quality fermentable saccharides. MCC was directly dissolved in phosphoric acid (the concentration was 83%) for 10 hours at temperatures of 30, 50, and 70 degrees C. The structural changes of MCC were determined in detail with X-ray powder diffraction, solid-state cross-polarization magic angle spinning (13)C-NMR, and X-ray photoelectron spectroscopy. The kinetics of MCC decrystallization during treatment with phosphoric acid was also compared at 30, 50, and 70 degrees C. With the assumption of first order kinetics, the Arrhenius parameters of K, A(0) and E(a) were calculated. The rate constants of decrystallization reaction (K) were 0.06, 0.17, and 0.12 h(-1) respectively. The pre-exponential factor (A(0)) was 1.2 x 10(6) h(-1), and the activation energy (E(a)) was 42.4 kJ/mol.
Characterization of a Counterpart to Mammalian Ornithine Decarboxylase Antizyme in Prokaryotes (2005)

The degradation of mammalian ornithine decarboxylase (ODC) (EC 4.1.1.17) by 26 S proteasome, is accelerated by the ODC antizyme (AZ), a trigger protein involved in the specific degradation of eukaryotic ODC. In prokaryotes, AZ has not been found. Previously, we found that in Selenomonas ruminantium, a strictly anaerobic and Gram-negative bacterium, a drastic degradation of lysine decarboxylase (LDC; EC 4.1.1.18), which has decarboxylase activities toward both L-lysine and L-ornithine with similar K(m) values, occurs upon entry into the stationary phase of cell growth by protease together with a protein of 22 kDa (P22). Here, we show that P22 is a direct counterpart of eukaryotic AZ by the following evidence. (i) P22 synthesis is induced by putrescine but not cadaverine. (ii) P22 enhances the degradation of both mouse ODC and S. ruminantium LDC by a 26 S proteasome. (iii) S. ruminantium LDC degradation is also enhanced by mouse AZ replacing P22 in a cell-free extract from S. ruminantium. (iv) Both P22 and mouse AZ bind to S. ruminantium LDC but not to the LDC mutated in its binding site for P22 and AZ. In this report, we also show that P22 is a ribosomal protein of S. ruminantium.
Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation (2017)

We report the C4-selective C-H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed σ-activation methodology, whereby C-H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals.
Electrical muscle stimulation after immediate nerve repair reduces muscle atrophy without affecting reinnervation (2012)

Short-term electrical muscle stimulation after nerve repair significantly reduces muscle atrophy and does not affect motor reinnervation.