gebhart/patrepeval huggingface dataset:
Intérêt de la mise en place d’une consultation post-urgence de pneumologie : évaluation à 21 mois (2015)

Les consultations aux urgences pour des problèmes respiratoires sont fréquentes. Certains patients n’ont pas de critères d’hospitalisation mais nécessitent une réévaluation clinique à court terme par un pneumologue. Or, il existe une réelle difficulté d’accès aux soins spécialisés. Pour contourner cet obstacle, une consultation post-urgence (CPU) a été mise en place dans le service de pneumologie de l’hôpital Tenon. L’objectif de ce travail était d’en évaluer l’activité et l’impact sur la prise en charge des patients. Nous avons réalisé une étude observationnelle, rétrospective de janvier 2012 à septembre 2013 sur la CPU de l’hôpital Tenon. Au total, 297 patients ont été programmés et 231 (78 %) sont venus en CPU lors de cette période. Nous avons inclus 170 patients dans l’étude car 21 % des patients venus n’étaient pas passées préalablement par les urgences. Les délais de consultation étaient relativement courts (huit jours en moyenne). L’asthme, la bronchopneumopathie chronique obstructive (BPCO) et les pathologies infectieuses représentaient la majorité des pathologies diagnostiquées. Le diagnostic retenu à la sortie de la CPU comparé à celui des urgentistes était concordant dans 50 % des cas, précisé dans 32 % des cas et discordant dans 18%des cas. Dans 44%, une modification thérapeutique a été effectuée à l’issue de la CPU. Dans 89 %, une nouvelle consultation de pneumologie, habituellement dans le service, a été programmée afin d’instaurer une prise en charge spécialisée exclusive ou partagée. La CPU a permis de modifier le diagnostic et/ ou le traitement à court terme de près de 50 % des patients et d’organiser leur prise en charge pneumologique dans près de 90 % des cas.
Mesangial cell complement receptor 1‐related protein y limits complement‐dependent neutrophil accumulation in immune complex glomerulonephritis (2009)

The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (GN). After 3 weeks of immunization with horse spleen apoferritin, six of nine Crry(-/-) C3(+/-) mice and none of the six control C3(+/-) mice developed proliferative GN (P = 0.010). After 5 weeks of immunization, GN scores in Crry(-/-) C3(+/-) mice were 0.67 +/- 0.22 mean +/- standard error of the mean (SEM), compared with 0.32 +/- 0.16 in C3(+/-) mice. Glomerular hypercellularity was attributable to neutrophil infiltration in mice with GN (1.7 +/- 0.3/glomerulus) compared with those without GN (0.4 +/- 0.1/glomerulus) (P = 0.001). Absent staining for alpha-smooth muscle actin and proliferating cell nuclear antigen suggested that mesangial cell proliferation did not play a significant role in this model. Serum C3 levels in Crry(-/-) C3(+/-) mice were approximately 20% and 30% those of wild-type mice and C3(+/-) mice, respectively. To determine whether this acquired hypocomplementaemia was relevant to this GN model system, Crry(-/-) C3(+/-) mouse kidneys were transplanted into wild-type mice followed by immunization with apoferritin for 1 or 2 weeks. Surprisingly, none of the Crry(-/-) C3(+/-) mouse kidneys developed GN at these early time-points, indicating that increasing circulating C3 levels several-fold did not increase susceptibility to GN. Renal expression of decay-accelerating factor was not different among any of the groups studied. Thus, our data indicate that mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition.
Structure and formation process of the glass film on grain-oriented silicon steel using aluminum nitride as an inhibitor (1999)

The oxide film formed during secondary recrystallization annealing of grain-oriented 3% Si steel using aluminum nitride as an inhibitor was investigated by x-ray diffraction analysis (XRD), glow discharge optical emission spectrometry (GD-OES), and quantitative chemical analysis (CA) in order to clarify the structure and the formation process. Spinel (MgAl2O4) was identified in addition to forsterite (Mg2SiO4) by XRD. From the consideration on the basis of the element distribution of Mg, Si, Al in the glass film and the quantitative correlation between the amount of spinel and that of forsterite, it was concluded that spinel was formed by the substitution reaction of Si in forsterite film for Al generated by decomposition of AIN.
Parameterized controller generation for multiple mode behavior (2014)

We derive and demonstrate a new capability for snake robots in which two behaviors-one for locomotion and the other for manipulation-are executed simultaneously on the same robot. This is done in two steps: 1) inverse kinematics via numerical optimization and 2) gait-based locomotion via modal decomposition. The result is an analytical representation of a multiple mode behavior that reduces online execution to simple parameterized control. This representation makes it possible to derive a feedback control law that enables reliable visual servoing using a snake robot while climbing a pole.
Zinc-finger protein p52-ZER6 accelerates colorectal cancer cell proliferation and tumour progression through promoting p53 ubiquitination (2019)

We identified p52-ZER6 as a novel oncogene that enhances MDM2/p53 complex integrity, and might be a potential target for anti-cancer therapy.
Non-Invasive Beam Detection in a High-Average Power Electron Accelerator (2013)

For a free-electron laser (FEL) to work effectively the electron beam quality must meet exceptional standards. In the case of an FEL operating at infrared wavelengths in an amplifier configuration the critical phase space tends to be in the longitudinal direction. Achieving high enough longitudinal phase space density directly from the electron injector system of such an FEL is difficult due to space charge effects, thus one needs to manipulate the longitudinal phase space once the beam energy reaches a sufficiently high value. However, this is fraught with problems. Longitudinal space charge and coherent synchrotron radiation can both disrupt the overall phase space, furthermore, the phase space disruption is exacerbated by the longitudinal phase space manipulation process required to achieve high peak current. To achieve and maintain good FEL performance one needs to investigate the longitudinal emittance and be able to measure it during operation preferably in a non-invasive manner. Using the electro-optical sampling (EOS) method, we plan to measure the bunch longitudinal profile of a high-energy (~120-MeV), high-power (~10kW or more FEL output power) beam.
Fusobacterium: elusive cause of life-threatening septic thromboembolism. (2007)

Lemierre syndrome (LS) is a life-threatening condition characterized by antecedent oropharyngeal infection, disseminated foci of infection or septic emboli, and bacteremia demonstrated by blood cultures positive for Fusobacterium .[1][1] Lemierre syndrome classically affects young, healthy men. At
Opening-Wedge High Tibial Osteotomy with a Locked Low-Profile Plate (2010)

Our results suggest that an opening-wedge high tibial osteotomy with locked plate fixation allows a correct valgus angle to be achieved with good short-term results.
COP I and II dependent trafficking controls ER-associated degradation in mammalian cells (2022)

Abstract Misfolded proteins and components of the endoplasmic reticulum (ER) quality control and ER associated degradation (ERAD) machineries concentrate in mammalian cells in the pericentriolar ER-derived quality control compartment (ERQC), suggesting it as a staging ground for ERAD. By tracking the chaperone calreticulin and an established ERAD substrate, asialoglycoprotein receptor H2a, we have now determined that the trafficking to the ERQC is reversible and recycling back to the ER is slower than the movement in the ER periphery. The dynamics suggest vesicular trafficking rather than diffusion. Indeed, using dominant negative mutants of ARF1 and Sar1 or the drugs Brefeldin A and H89, we observed that COPI inhibition causes accumulation in the ERQC and increased retrotranslocation and ERAD, whereas COPII inhibition has the opposite effect. Our results suggest that targeting of misfolded proteins to ERAD involves COPII-dependent transport to the ERQC and that they can be retrieved to the peripheral ER in a COPI-dependent manner.
IN VITRO INDUCTION OF SPECIFIC UNRESPONSIVENESS OF IMMUNOLOGICALLY REACTIVE, NORMAL BONE MARROW CELLS (1970)

Normal rabbit bone marrow cells have been studied according to their immunological reactivity in vitro. The test system involved stimulation by antigen after the subsequent stimulation into cellular proliferation by measuring the uptake of tritium-labeled thymidine. Specific separation of immunological reactivity was obtained by filtration of cells through antigen-coated bead columns. All experimental evidence supported the view that this separation was due to the existence of preformed antibody molecules on the outer cell surface of the antigen-recognizing cells. The response to antigenic stimulation was shown to be strictly dose related and, using supraoptimal concentrations of one antigen, no increased DNA synthesis was recorded. That this state of unresponsiveness represented a state of immunological paralysis was indicated by the normal response of these cells to stimulation by a second antigen in optimal concentration. Thus both methods, cell separation on antigen-coated columns or induction of specific unresponsiveness by antigen in vitro, can produce a cell population specifically devoid of cells reactive against a given antigen.
The regulation of membrane lipid metabolism (1980)

A RATIONALE GOVERNING THE REGULATION OF LIPID METABOLISM. Tissue-Specific Distribution of Lipids. The Physiological Significance of Lipid Tissue Specificity. Response of Lipid Composition to Environmental Perturbation. The Role of Lipids in Abnormal and Disease States. Recapitulation. FATTY ACID BIOSYNTHESIS. The Pathway. Cellular Location. The Regulatory Enzymes. FATTY ACID MODIFICATION. Fatty Acid Activation. Fatty Acid Elongation. Fatty Acid Desaturation. Metabolism of Cyclopropane Fatty Acids. Conversion of Straight-Chain to Branched-Chain Fatty Acids. Biohydrogenation of Unsaturated Fatty Acids. Fatty Acid Oxidation. Reduction of Fatty Acids to Fatty Alcohols. PHOSPHOLIPIDS. Regulation of the Phosphatidic Acid Pool. Regulation of the Diacylglycerol Pool. De Novo Synthesis of Phosphatidylcholine. De Novo Synthesis of Phosphatidylethanolamine. Phospholipid Interconversion by Exchange of Polar Head Groups. Formation of Phosphatidylethanolamine and Phosphatidylcholine by Enzymatic Modification of Phosphatidylserine. Formation of CDP-Diacylglycerols From Phosphatidic Acid. De Novo Synthesis of Phosphatidylserine, Phosphatidylinositol, Phosphatidylglycerol and Cardiolipin. Metabolism of Polyphosphoinositides. Phosphonolipids. Phospholipids Containing Ether Bonds. Metabolism of Sphingomyelin. Regulatory Function of Lipid-Degrading Enzymes. Turnover of Phospholipid Acyl Groups. Overview of Phospholipid Metabolism in Bacteria. Overview of Phospholipid Metabolism in Animals. Overview of Phospholipid Metabolism in Plants. STEROL METABOLISM. The Mechanisms of Sterol Biosynthesis. Regulation of Cholesterol Biosynthesis. Regulation of Sterol Analog Metabolism. Regulation of Sterol Catabolism. THE REGULATION OF NON-STEROID ISOPRENOID METABOLISM. Chlorophyll. Carotenoids. Lipids of Archaebacteria. THE REGULATION OF GLYCOLIPID METABOLISM. Glycolipid Metabolism in Animals. Glycolipid Metabolism in Plants. LIPIDS COVALENTLY BOUND TO PROTEINS. Fatty Acylated Proteins. Isoprenylated Proteins. Proteins Anchored to the Membranes by a Phosphatidylinositol Glycan. THE SPECIFICITY AND RATES OF INTRACELLULAR LIPID MOVEMENT. The Intracellular Movement of Lipids Via Membrane Flow. Unimolecular Transport of Lipids. The Maintenance of Lipid Asymmetry. THE EFFECTS OF EXOGENOUS LIPIDS UPON LIPID METABOLISM. Effects of Exogenous Fatty Acids. Effects of Exogenous Ether Lipids. Effects of Exogenous Sterols. Effects of Exogenous Precursors of Phospholipid Head Groups. THE EFFECTS OF ENVIRONMENTAL FACTORS ON LIPID METABOLISM. Adaptive Responses to Environmental Stress. Conclusions.
Metrics for Success: Performance Metrics for Power System State Estimators and Measurement Designs (2012)

Power system state estimators (ses) have come a long way since the introduction of the concept nearly four decades ago by Fred Schweppe. Over the years, the concept's initial formulation, implementation techniques, computational requirements, data manipulation and storage capabilities, and measurement types have changed significantly. Today, SEs are instrumental in facilitating the security and reliability of power system operation and play an important role in the management of power markets where transactions have to be carefully evaluated for feasibility and determination of real-time prices. One of the most recent developments in SEs has been the availability of synchronized phasor measurements and their introduction into the state estimation process. Synchrophasor-assisted state estimation (SPASE) is changing the way we view and operate the grid. As such, the ability to monitor and maintain SE performance within known performance standards (metrics) is a new practice. Unlike deterministic applications such as power fl ow, the state estimation solution is not deterministic and depends on the statistical characteristics of the measurements as well as the level of certainty of the assumed network model.
Efficacy and Safety of ACE Inhibitor and Angiotensin Receptor Blocker Therapies in Primary Focal Segmental Glomerulosclerosis Treatment: A Systematic Review and Meta-Analysis (2022)

This review supports the tendency to observe a proteinuria reduction with RAAS inhibitors in patients with primary FSGS. RAAS inhibitor monotherapy was associated with maintained kidney function, as shown by no change in creatinine clearance. Strong evidence to quantify the effects of RAAS inhibitor monotherapy on end-stage kidney disease and glomerular filtration rate was lacking. Larger, well-designed clinical trials are needed to better understand the effects of RAAS inhibitors on primary FSGS.
Optimizing inter-instruction value communication through degree of use prediction (2004)

The design of high-performance value communication structures represents a significant chal-lenge in the implementation of future microprocessors. The complexity of these structures— namely, the register file, the bypass network, and the instruction window—dwarfs that of the actual instruction execution hardware and has become the predominant factor in determining the maximum operating frequency. Being wire-dominated, these structures also benefit less from technology scaling than the execution circuitry, increasing the importance of this problem. Value communication structures are complex because they are overly general. Each of these structures is built to support the most general possible communication pattern for each value. However, examining value communication in actual programs reveals that most values are involved in simple communication, such as producer to single consumer. This dissertation pro-poses an alternate model for inter-instruction register value communication in which values may be handled differently by mechanisms optimized to their individual needs. The foundation for this model is knowledge of communication on a per-value basis. The com-munication resource requirements of a value are summarized by its degree of use, which is simply
Thermally Controlled agnetization Actuator using Thermosensitive Magnetic Materials (1994)

A thermally controlled magnetization actuator (TCMA), that is actuated by changing the local magnetization of the structure by spot heating, is proposed and its feasibility is confirmed experimentally. The generated torque of this actuator is measured with a millimeter size torsional oscillator to confirm its feasibility. The torque variant achieved with thermally controlled magnetization is almost as large as that achieved with electromagnetization (current controlled magnetization). An integrated thermally controlled magnetization microrelay is fabricated to demonstrate the possibility of micrometer size actuating. The size of relay unit is 200 x 1500 pm. Its armature beam is 10 pm thick, 5 pm wide, and 500 pm long, and the tip is shaped like a hammer to increase the volume of magnetic material. The armature bending of 5 pm has been achieved by attractive force between the stator and the hammer, enough for self-latching. Switching motion is created by 25 W/mm2 of infrared laser beam irradiation. The contact force is calculated to be around 4 pN.
GIS Spatial Modeling for Land Degradation Assessment in Tigray, Ethiopia (2012)

Land degradation can be described as reduction in the present and prospective land quality and production, due to natural or anthropogenic dynamics. This phenomenon is one of the most important problems facing farmers and decision makers in several countries. This study aims to use GIS spatial modeling to quantify land (physically and chemically) degradation in the study area based on remotely sensed and field survey’s data. A GIS spatial model has been developed based on the LADAFAO methodology to apply a land degradation assessment in the study area. Final land degradation map has been produced by combining the outputs of different types of land degradation. The results show that the majority of the study area fall under the very low and low land degradation classes. High land degradation class has been found in areas affected by high soil loss, because of erosion and high or moderate deficiency of nutrients in the soil. Moderate land degradation class can be found in areas where soil physical degradation high is, while nutrients deficiency is moderate. Results also show that approximately quarter of the study area needs attention and degradation recovery plans to prevent losing these lands, so more work needs to be done to specify the main controlling agents of degradation to be recovered. GIS spatial modeling tools manifested great efficiency in land degradation assessment process, whose results hopefully may help decision makers to take the necessary actions to protect the most degraded spots.
A Convenient Method for the Preparation of 1-(Phenylsulfonyl)-1-alkynes (2002)

A three-step procedure for the synthesis of 1-(phenylsulfonyl)-1-alkynes is described. The method involves preparation of β-ketosulfones 2 either by addition of lithio(phenylsulfonyl)methane to ε-caprolactone followed by hydroxyl protection. Subsequent treatment with triflic anhydride-Hünig's base gives 1-(phenylsulfonyl)-1-alkynes 3 in good overall yield. Tetrahydropyranyl, benzyl and t-butyldimethylsilyl ethers, and acetate esters are tolerant of the reaction conditions.
Self-assembly of DNA nanostructures in different cations (2023)

The programmable nature of DNA allows the construction of custom-designed static and dynamic nanostructures, and assembly conditions typically require high concentrations of magnesium ions which restricts their applications. In other solution conditions tested for DNA nanostructure assembly, only a limited set of divalent and monovalent ions have been used so far (typically Mg <sup>2+</sup> and Na <sup>+</sup> ). Here, we investigate the assembly of DNA nanostructures in a wide variety of ions using nanostructures of different sizes: a double-crossover motif (76 bp), a three-point-star motif (∼134 bp), a DNA tetrahedron (534 bp) and a DNA origami triangle (7221 bp). We show successful assembly of a majority of these structures in Ca <sup>2+</sup> , Ba <sup>2+</sup> , Na <sup>+</sup> , K <sup>+</sup> and Li <sup>+</sup> and provide quantified assembly yields using gel electrophoresis and visual confirmation of a DNA origami triangle using atomic force microscopy. We further show that structures assembled in monovalent ions (Na <sup>+</sup> , K <sup>+</sup> and Li <sup>+</sup> ) exhibit up to a 10-fold higher nuclease resistance compared to those assembled in divalent ions (Mg <sup>2+</sup> , Ca <sup>2+</sup> and Ba <sup>2+</sup> ). Our work presents new assembly conditions for a wide range of DNA nanostructures with enhanced biostability.
Transmission characteristics of graded-index optical fibers with a lossy outer layer (1978)

Changes in transmission characteristics caused by an outer layer have been investigated for graded-index fibers. Equations have been derived using the WKB method for calculating baseband frequency response and excess loss in a general type of the graded-index fiber. Numerical examples have been given for a square-law fiber, mainly with cladding thickness and index difference between outer layer and cladding as parameters. Measurement of the excess loss has been carried out for fibers with various cladding thickness and outer layer-cladding index differences. The measured loss is in agreement with the theoretical value.
66 Relative efficacy of sacubitril/valsartan, dapagliflozin and vericiguat: a systematic review and network meta-analysis (2020)

Abstract Aims Sacubitril/valsartan, dapagliflozin and vericiguat have shown a prognostic benefit in phase 3 trials on heart failure with reduced ejection fraction (HFrEF). Assessing their relative efficacy is an important goal. Methods and results We assessed the relative efficacy of dapagliflozin, sacubitril/valsartan and vericiguat, by comparing the treatment arms with the respective control arms (standard of care) through a network meta-analysis. The phase 3 trials (PARADIGM-HF, DAPA-HF, VICTORIA), the HFrEF subgroup of DECLARE-TIMI 58, and a phase 2 trial on vericiguat were evaluated. Dapagliflozin was associated with a non-significant reduction in the risk of cardiovascular (CV) death or HF hospitalization compared to sacubitril/valsartan (hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.64 to 1.22) and vericiguat (HR 0.82, 95% CI 0.6 to 1.12). The risk of CV death did not differ significantly between patients on dapagliflozin or sacubitril/valsartan (HR 0.90, 95% CI 0.51 to 1.58), and between patients on dapagliflozin or vericiguat (HR 0.77, 95% CI 0.44 to 1.37). As for HF hospitalization, dapagliflozin conferred a significant benefit over vericiguat (HR 0.77, 95% CI 0.63 to 0.93), but not over sacubitril/valsartan (HR 0.87, 95% CI 0.72 to 1.06). Dapagliflozin was ranked as the most effective therapy, followed by sacubitril/valsartan and vericiguat. Conclusion Based on an indirect comparison, dapagliflozin is not associated with a significantly lower risk of CV death or HF hospitalization or CV death alone compared to sacubitril/valsartan or vericiguat. The risk of HF hospitalization does not differ significantly between patients on dapagliflozin or sacubitril/valsartan, while dapagliflozin is superior to vericiguat. Registration number PROSPERO ID 186351.