gebhart/patrepeval huggingface dataset:
HPGe compton suppression using pulse shape analysis (1998)

We present a new technique for High Purity Germanium (HPGe) Compton suppression using pulse shape analysis (PSA). The novel aspect of our approach involves a complete unfolding of the charge pulse shape into a discrete sum of component y-ray interactions. Using the energy and position information obtained from such an unfolding, an algorithm is then applied which favorably rejects Compton escape events. The advantage of the current PSA approach, as compared with other recent approaches, is the potential to reject not only single-site escape events, but also multiple site escape events. Here we discuss the details of our algorithm, and present experimental results from a real-time implementation on a 5 cm X 5 cm HPGe. An experimental comparison with a standard BGO suppresser is shown. We also discuss the possible improvements to the current PSA approach that could be obtained if the HPGe could be highly segmented on the outer contact.
OCT1 mediates hepatic uptake of sumatriptan and loss‐of‐functionOCT1polymorphisms affect sumatriptan pharmacokinetics (2015)

The low bioavailability of the anti-migraine drug sumatriptan is partially caused by first-pass hepatic metabolism. In this study, we analyzed the impact of the hepatic organic cation transporter OCT1 on sumatriptan cellular uptake, and of OCT1 polymorphisms on sumatriptan pharmacokinetics. OCT1 transported sumatriptan with high capacity and sumatriptan uptake into human hepatocytes was strongly inhibited by the OCT1 inhibitor MPP(+) . Sumatriptan uptake was not affected by the Met420del polymorphism, but was strongly reduced by Arg61Cys and Gly401Ser, and completely abolished by Gly465Arg and Cys88Arg. Plasma concentrations in humans with two deficient OCT1 alleles were 215% of those with fully active OCT1 (P = 0.0003). OCT1 also transported naratriptan, rizatriptan, and zolmitriptan, suggesting a possible impact of OCT1 polymorphisms on the pharmacokinetics of other triptans as well. In conclusion, OCT1 is a high-capacity transporter of sumatriptan and polymorphisms causing OCT1 deficiency have similar effects on sumatriptan pharmacokinetics as those observed in subjects with liver impairment.
Appellate Practice and Procedure (2004)

This Article reviews federal appellate procedure decisions in the Eleventh Circuit during the 2005 calendar year. Questions considered this year include the following: statutory limitations on federal subject matter jurisdiction, general federal judicial jurisdiction, the appellate jurisdiction of federal circuit courts of appeal, and requirements for preservation of the record for appeal. This year, we again include a section on the standards of review that the Eleventh Circuit applies in reviewing the orders of federal district courts. The particular standards reviewed include the de novo, abuse of discretion, and clear error standards.
Issues and Requirements for Server Name Identification (SNI) Encryption in TLS (2020)

This draft describes the general problem of encrypting the Server Name
Identification (SNI) TLS parameter. The proposed solutions hide a
Hidden Service behind a fronting service, only disclosing the SNI of
the fronting service to external observers. The draft lists known
attacks against SNI encryption, discusses the current co-tenancy
fronting solution, and presents requirements for future TLS layer
solutions. In practice, it may well be that no solution can meet every
requirement, and that practical solutions will have to make some
compromises.
Evaluating Novel Diagnostics in an Outbreak Setting: Lessons Learned from Ebola (2017)

Inadequate access to rapid testing for Ebola virus disease during the 2014-to-2016 outbreak led to an explosion in the development of diagnostics that could be performed at or near the point of care and by less-experienced operators, leading in turn to an acute need for novel test evaluation. Here, we present the challenges to development and evaluation of novel diagnostics in an emergency setting and suggestions for potential new "global emergency standards" to address them.
Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting (2012)

Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.
Association of maternal birth weight with the risk of low birth weight and small-for-gestational-age in offspring: A prospective single-center cohort study (2021)

Our findings suggest that lower maternal birth weight is associated with small-for-gestational-age and low birth weight in offspring of women born at term.
Gonadotropin-releasing hormone receptor messenger ribonucleic acid expression in rat ovary. (1995)

Rat GnRH pituitary receptor complementary DNA was used to isolate a truncated clone from a rat corpus luteum complementary DNA library that proved to be identical in sequence to the rat anterior pituitary GnRH receptor. The distribution of the GnRH receptor messenger RNA (mRNA) was then determined in rat ovary using in situ hybridization. GnRH receptor expression was investigated in cyclic female rats and in hypophysectomized immature female rats treated with either recombinant human FSH or human menopausal gonadotropin. The expression of LH receptor mRNA was determined in serial sections as an index of the health and differentiation of the follicles. In cyclic animals, GnRH receptor mRNA was detected in granulosa cells at varying stages of follicular development and in the corpus luteum. Ovaries from hypophysectomized animals expressed GnRH receptor mRNA in the granulosa cells of most follicles. The administration of FSH or human menopausal gonadotropin to hypophysectomized animals altered the distribution of GnRH receptor mRNA. During antral development, the signal was most abundant in medium-sized follicles not expressing LH receptor mRNA and showing signs of follicular atresia. However, healthy preovulatory follicles also expressed GnRH receptor mRNA. We conclude that the expression of the GnRH receptor gene in granulosa cells is 1) individually regulated for each follicle, 2) persists in the corpus luteum, and 3) expressed in atretic follicles.
Metal–ligand bonding properties of double-sided porphyrin complexes: influence of bulky ester groups (1991)

Metal–ligand bonding properties of double-sided porphyrinato-iron(II) and -cobalt(II) complexes have been characterized by ESR, IR, and Mössbauer spectroscopy. The smaller AN value for a 1-methyl-imidazole (mim) adduct of 5,10,15,20-tetra(2,6-dipivaloyloxyphenyl)porphyrinatocobalt(II) compared to that of 5,10,15,20-tetra(2,6-di-tert-butylacetoxyphenyl)porphyrinatocobalt(II) suggested that the cobalt–imidazole bond is weak. The ESR spectrum of the dioxygenated double-sided series in fluid toluene indicated that an electrostatic interaction between the bound dioxygen and the ester fences was rarely found. The relaxation of steric strain on the rear side of the ring plane for axial imidazole bonding resulted in a lowering of the bound CO and O2 stretching frequencies of iron(II) complexes. This indicates that the π-back donation from the dπ orbital of the iron to the π* orbital of the bound gaseous ligand could be controlled by the strength of the iron–imidazole bonding, which is regulated by the structure of the rear pocket on the macrocycle. The co-ordination structure of various ligands in double-sided porphyrinatoiron complexes is also discussed by means of Mössbauer parameters.
Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma (2023)

&lt;p&gt;Supplementary Table 1. A)Patient details for Fresh Frozen test cohort, B) Patient details for validation cohort. Supplementary Figure 1. APOBEC mutation fraction of across multiple cancer types. Supplementary Figure 2. DNA methylation. Supplementary Figure 3. Candidate PeCa driver mutations. Supplementary Figure 4. Schematic of FAT1 is shown with locations of mutations and ethylation states of PeCa and normal penile tissue across the canonical FAT1 gene. Supplementary Figure 5. A) Example plot of Copy Number Alterations (CNA) in penile cancers, 450K methylation profiles for penile cancer and normal squamous epithelium, and output from GISTIC showing the frequency and significance of CNAs.&lt;/p&gt;
A report on tribological properties of selected vegetable oil based lubricants (2008)

The University of Northern Iowa's National Ag-Based Lubricants Center (UNI-NABL) was established in 1991. Researchers at the Center have specialized in the R&amp;D of vegetable-based lubricants and have become a nationally recognized technical service organization in the US. UNI-NABL has successfully marketed and licensed &gt; 35 industrial lubricants products, mostly from soybean oils. Vegetable oils exhibit higher lubricity, better adherence to metals, higher flash and fire points, and higher viscosity index. These biolubricants are competitive in performance and are achieving price parity as compared to their petroleum counterparts. A discussion covers the friction and wear properties of crude commodity soybean oil, genetically modified high oleic soybean oil, and a mineral oil of similar viscosity; friction and wear relationship; properties of hydraulic oils and selected metalworking fluids; and testing criteria. This is an abstract of a paper presented at the 16th International Colloquium Tribology Lubricants Materials and Lubrication Engineering (Stuttgart/Ostfildern, Germany 1/15-17/2008).
Review of Croston's method for intermittent demand forecasting (2012)

Accurate demand forecasting is of vital importance in inventory management of spare parts, while the intermittent nature makes demand forecasting for spare parts especially difficult. Generally, intermittent demand appears at random, with many time periods showing no demand at all. Croston's method is widely used to predict inventory demand when it is intermittent. This paper gives a review of Croston's method for intermittent demand forecasting. Some limitations of the current Croston's method and its variants have been summarized and analyzed, and then the potential direction for future research has been suggested.
Intra angular prediction with weight function and modification filter (2013)

Standardization of a new video coding standard, High Efficiency Video Coding (HEVC version 1), has been completed and its compression ratio is twice as much as that of H.264/AVC under the condition of the same subjective quality. In HEVC, many coding tools contribute to the improvement of the coding efficiency. One example is the intra angular prediction mode that has finer prediction directions compared to H.264/AVC. In this paper, we propose two modified intra angular prediction methods: (A) reference pixels that are closer to the predicted pixels than the original reference pixels are exploited, and (B) a blending filter similar to the filter used in the intra DC mode is enhanced and applied. In the proposed method, the predicted signals of the angular prediction mode are generated by blending the predicted signals of the selected angular prediction mode and those of the other mode which has the opposite prediction direction. The overall average coding gain against the HM9.0.1 RExt 1.0 anchor was about 0.5% for the combined method. The maximum coding gain was about 1.0%. The average encoding and decoding run-times were 104.1% and 103.4%, respectively.
Very Long Wavelength InGaAs/GaAs Quantum Well Infrared Photodetector (1994)

There has been much interest in very long-wavelength quantum well infrared photodetectors and associated intersubband absorption due to their mature technology and the possibility of producing high performance large area two-dimensional imaging arrays.
BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres (2014)

Biological resources (cells, tissues, bodily fluids or biomolecules) are considered essential raw material for the advancement of health-related biotechnology, for research and development in life sciences, and for ultimately improving human health. Stored in local biobanks, access to the human biological samples and related medical data for transnational research is often limited, in particular for the international life science industry. The recently established pan-European Biobanking and BioMolecular resources Research Infrastructure-European Research Infrastructure Consortium (BBMRI-ERIC) aims to improve accessibility and interoperability between academic and industrial parties to benefit personalized medicine, disease prevention to promote development of new diagnostics, devices and medicines. BBMRI-ERIC is developing the concept of Expert Centre as public-private partnerships in the precompetitive, not-for-profit field to provide a new structure to perform research projects that would face difficulties under currently established models of academic-industry collaboration. By definition, Expert Centres are key intermediaries between public and private sectors performing the analysis of biological samples under internationally standardized conditions. This paper presents the rationale behind the Expert Centres and illustrates the novel concept with model examples.
OSPFN: An OSPF Based Routing Protocol for Named Data Networking (2012)

Named Data Networking (NDN) is a new data-centric network architecture. In NDN, users send Interest messages to retrieve data by their names. Since the Interest messages do not contain source or destination addresses, routers need to forward them based on the names carried in the messages. In order to provide name-based routing capability in NDN, we have extended OSPF to distribute name prexes and calculate routes to name prexes. Our protocol OSPFN is currently deployed in the NDN testbed. This report describes our design, implementation, deployment, and future work.
Knowledge-Enhanced Top-K Recommendation in Poincaré Ball (2021)

Personalized recommender systems are increasingly important as more content and services become available and users struggle to identify what might interest them. Thanks to the ability for providing rich information, knowledge graphs (KGs) are being incorporated to enhance the recommendation performance and interpretability. To effectively make use of the knowledge graph, we propose a recommendation model in the hyperbolic space, which facilitates the learning of the hierarchical structure of knowledge graphs. Furthermore, a hyperbolic attention network is employed to determine the relative importances of neighboring entities of a certain item. In addition, we propose an adaptive and fine-grained regularization mechanism to adaptively regularize items and their neighboring representations. Via a comparison using three real-world datasets with state-of-the-art methods, we show that the proposed model outperforms the best existing models by 2-16% in terms of NDCG@K on Top-K recommendation.
Optical Imaging of Transformed Breast Epithelial Cells and Breast Tumor Microenvironment (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text V. Leautaud, V. Mack, J. N. Wright, J. Lu, D. Yu, and R. Richards-Kortum, "Optical Imaging of Transformed Breast Epithelial Cells and Breast Tumor Microenvironment," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper BSuD76. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Epidemiology of Vocal Fold Paralyses after Total Thyroidectomy for Well‐Differentiated Thyroid Cancer in a Medicare Population (2014)

Annual rates of postthyroidectomy vocal fold paralyses are decreasing among Medicare beneficiaries with WDTC. High incidence in this aged population is likely due to a preponderance of temporary paralyses, which is supported by the need for directed intervention in less than a quarter of affected patients. Further population-based studies are needed to refine the population incidence and risk factors for paralyses in the aging population.
NF‐L and peripherin immunoreactivities define distinct classes of rat sensory ganglion cells (1991)

Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). About 6% were both peripherin- and NF-L-positive. All of the DRG neurons reacted with antibodies to NF-M and nonphosphorylation-dependent or phosphorylation-independent antibodies to NF-H. The neuropeptides were predominantly found in the peripherin-positive small cell population. Eighty-seven percent of the peripherin-positive small cell population contained substance P immunoreactivity, while 43% of this cell population contained CGRP. In contrast, only 18-24% of the NF-L-positive large-cell population contained neuropeptides, and these were primarily in a smaller sized subpopulation. Similar patterns of antigen representation were observed in neonatal (PN2) DRG cell populations. Tissue cultures of sensory ganglion cells from PN2 DRG, in serum-free medium, stably maintained exclusively peripherin-positive neurons, with about 5% of these containing coexistent NF-L immunoreactivity. Very high levels of neuropeptide gene expression were exhibited by these postnatal neurons in culture.
Simian virus 40 and malignant mesothelioma (Review) (2003)

Simian virus 40 (SV40) was recognized as a contaminant of early poliovirus vaccines that were provided to millions of individuals in Europe and in the USA between 1955 and 1963. SV40, a DNA virus of the family of papovaviridae, was proven to be oncogenic in rodents and able to transform human and animal cells in vitro. In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, SV40 DNA sequences were detected with significative frequency in human pleural mesotheliomas by using polymerase chain reaction (PCR) and then SV40 DNA oncogenicity was associated with its large T antigen (Tag). This finding was confirmed by many laboratories, while a few research groups failed to replicate these data and argued that the SV40 DNA detection might be a PCR contamination artefact. In this review the dispute is examined in the light of recent experiments performed to identify molecular and cellular aspects of carcinogenicity and/or co-carcinogenicity of SV40 in human mesothelioma.
Independent receptors for diadenosine pentaphosphate and ATP in rat midbrain single synaptic terminals (2001)

Diadenosine pentaphosphate (Ap5A) and adenosine 5'-triphosphate (ATP) stimulate a intrasynaptosomal calcium concentration [Ca(2+)](i) increase via specific purinergic receptors in rat midbrain synaptosomes, although nothing is known about their distribution in presynaptic terminals. A microfluorimetric technique to measure [Ca(2+)](i) increase using the dye FURA-2AM, has permitted study of the presence of dinucleotide and P2X receptors in independent isolated synaptic terminals. Our results demonstrate the existence of three populations of synaptosomes: one with dinucleotide receptors (12%), another with P2X receptors (20%) and a third with both (14%). It has been possible to demonstrate that the activation of these receptors occurs only in the presence of extracellular Ca(2+) and that it is also coupled with voltage-dependent Ca(2+) channels. Finally 54% of the synaptosomes that responded to K(+) did not present any calcium increase mediated by the nucleotides used. In summary, ATP and dinucleotides exhibit specific ionotropic receptors that can coexist or not on the same synaptic terminal.
Implantation of one versus two MitraClips in the German TRAMI registry: Is more always better? (2019)

TRAMI data cannot support the theory that implantation of more than one clip is associated with better clinical outcomes. The finding of more cerebral-vascular events after two-clip procedures might be hypothesis-generating.
A Newly Developed Miniaturized Heart‐Lung Machine—Expression of Inflammation in a Small Animal Model (2010)

Cardiopulmonary bypass may cause severe inflammatory reactions and multiorgan failure, especially in premature and low-weight infants. This is due in part to the large area of contact with extrinsic surfaces and the essential addition of foreign blood. Thus, we developed a new miniaturized heart-lung machine (MiniHLM) with a total static priming volume of 102mL (including arterial and venous lines) and tested it in a small animal model. Seven Chinchilla Bastard rabbits were perfused with the MiniHLM (dynamic priming volume 127mL). Seven animals serving as a control were perfused using Dideco Kids and a Stöckert roller pump (modified dynamic priming volume 149mL). The rabbits were anesthetized and sternotomized, followed by cannulation of the aorta and the right atrium. The aorta was clamped for 1h. Blood for examination of inflammation (TNF-α, IL-1β, IL-6, IL-8, and IL-10) and blood gas analysis were taken before skin incision, 5min before opening of the aorta, 15min after opening of the aorta, and 4 h after the initiation of cardiopulmonary bypass. The parameters of inflammation were expressed by means of the comparative C(T) method (ΔΔC(T) method). After gradual reduction of perfusion with the HLM, the heart was decannulated, and the sternum was closed. All rabbits were successfully weaned from cardiopulmonary bypass. Blood gas analysis was unremarkable in all cases. Foreign blood was not administered. Although statistical significance was not achieved, there was a reduced expression of inflammatory markers in the MiniHLM group. The newly developed MiniHLM prototype was tested successfully in a small animal model in terms of technical function and expression of inflammation. Upcoming tests with the industrially manufactured MiniHLM may reveal the advantages of the MiniHLM in comparison with the conventional HLM.