gebhart/patrepeval huggingface dataset:
Role of Fc Receptors as a Therapeutic Target (2009)

It has been forty years since the discovery of Fc Receptors and their function. Fc Receptors include the IgG receptors (FcgammaR), high-affinity IgE receptor (FcepsilonRI), IgA and IgA/IgM receptors, and neonatal Fc receptor for IgG (FcRn). In particular, the FcgammaRs have been well known to play an important role in many biologic processes including those associated with the response to infection and cancer as well as in the pathogenesis of immune-mediated diseases. Both positive and negative regulatory function has ascribed to Fc receptors and FcgammaRs in particular which serve to establish a threshold for immune cell activation. In other cases, Fc receptors such as FcRn possess a novel structure and function by playing a major role in the transport of IgG across polarized epithelial barriers at mucosal surfaces and in the regulation of IgG half-life. These diverse functions highlight the potential effectiveness of targeting Fc receptors for therapeutic purposes. This review summarizes new information available in the therapeutic applications of this biology.
Evaluation of the risk factors associated with conversion of intended deep anterior lamellar keratoplasty to penetrating keratoplasty (2019)

705 eyes were included, with conversion to PK occurring in 16.2% (n=114) of cases. The factors that remained significant in multivariate analysis were corneal scarring (OR=3.52, p<0.001), manual dissection (OR=42.66, p<0.001), type 2 bubble (OR=90.65, p<0.001) and surgeon inexperience (OR=10.86, p<0.001). A receiver operating characteristic (ROC) curve based on the factors significant in the multivariate binary logistic regression analysis achieved a sensitivity of 89.5% (95% CI 82.3% to 94.4%) and a specificity of 80.2% (95% CI 76.8% to 83.3%) with an area under the ROC curve of 0.91 (95% CI 0.88 to 0.93) (p<0.001) CONCLUSION: Occurrence of a type 2 bubble, the need for manual dissection, the presence of scarring and surgeon inexperience are independent risk factors for the need to convert intended DALK to PK. Correct identification and management of the type of bubble achieved during pneumatic dissection is instrumental in minimising the rate of conversion to PK.
The Ru(cod)(cot)‐Catalyzed Alkenylation of Aromatic C—H Bonds with Alkenyl Acetates. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation (2002)

Breath tests are a simple and safe alternative to more invasive investigation strategies for many gastroenterological conditions. Both the hydrogen breath tests and the new 13C stable radioisotope breath tests are nonradioactive and safe in children and pregnancy. The range of diseases that can be identified include Helicobacter pylori infection, lactose and fructose intolerance, bacterial overgrowth, bile salt wastage, pancreatic insufficiency, liver dysfunction, and abnormal small bowel transit. In this review, the physiology supporting these tests and the principles of normal gas dynamics in the gut are briefly reviewed and then related to the test preparation and interpretation in two parts: 1) detection of H. pylori and 2) small bowel, pancreatic, and hepatobiliary disorders. A MEDLINE search reviewing all English language abstracts from 1966 to March, 2001 was performed, with an additional review of abstracts from major national meetings from 1997 to 2001. Using the information from this review, the performance characteristics of the various tests were detailed, and an attempt is made to provide some literature-based guidance regarding their indications and limitations. The interpretation of "flat" breath tests and the selective use of methane collection and colonic alkalinization are discussed. Breath tests are valuable tools that are, in general, underutilized in evaluating dyspepsia and functional bloating and diarrhea, as well as suspected malabsorption, including lactose intolerance.
ChemInform Abstract: ADDITION REACTIONS OF BENZO(B)THIOPHENE. PART 1. SELF‐ADDITION AND ADDITION OF SIMPLE AROMATIC HYDROCARBONS (1980)

Abstract Beim Umsetzen mit AlCl 3 in organischen Lösungsmitteln bei Ooder 20°C geht Benzo[b]thiophen (I) leicht Additionsreaktionen an dem 2‐C‐ und/oder 3‐C‐Atom ein.
Asymmetric synthesis of the northern segment of ephedradine C (2000)

An asymmetric synthesis of the dihydrobenzofuran segment of ephedradine C has been achieved. Key steps include a chiral oxazolidinone-mediated aldol reaction to form a β-hydroxy ester, followed by a novel debenzylation and concomitant intramolecular cyclisation with iodotrimethylsilane. An asymmetric Michael reaction with a homochiral lithium amide was used to form the third and final chiral centre. The absolute stereochemistry of these three centres was confirmed by X-ray crystal-structure determinations.
Selective Reduction of Orgainc Compounds with Al-Fluorodiisobutylalane (2009)

The new MPV-type reagent, Al-fluorodiisobutylalane (DIBAF), has been prepared and their reducing characteristics in the reduction of selected organic compounds containing representative functional groups have been examined in order to find out a new reducing system with unique applicability in organic synthesis. In general, the reagent is extremely mild, showing only reactivity toward aldehydes, ketones, and epoxides. The reagent achives a clean 1,2-reduction of enals to the corresponding allylic alcohols in a 100% purity, but shows no reactivity toward enones. The reagent also shows an excellent regioselective cleavage of substituted epoxides. In addition, DIBAF produces the thermodynamically more stable alcohol epimer in high stereoselectivity in the reduction of cyclic ketones.
Effect of negative air ions on morphine‐induced changes in the latency of the tail‐flick reflex (1990)

Abstract Adult male Long‐Evans rats were exposed to negatively charged air ions at high concentrations (7 × 10 5 /cm 3 ) for six days. Sham‐exposed rats were treated identically except that the source of ions was not activated. At the end of the exposure, the latency of the tail‐flick reflex was measured in each rat before and 30 and 60 min after an injection of morphine sulphate. The tail‐flick reflex was initiated by thermal stimulation. Two heat settings were employed, the lower considered to impart a submaximal and the higher a maximal thermal stimulus. Three morphine doses were tested: 0.5, 1.0, and 1.5 mg/kg. Statistically significant differences between ion‐exposed and sham‐exposed rats were observed in tail‐flick latencies 30 min after the administration of the two lower doses, but not after the highest dose of morphine sulphate. These differences were found at both intensities of thermal stimulation. Tail‐flick latencies measured in each group prior to morphine injection were not affected by negative‐ion exposure. The data indicate that exposure of rats to negative air ions tends to inhibit the action of morphine on the latency of the tail‐flick reflex at morphine doses below 1.0 mg/kg.
DALIA- a comprehensive resource of Disease Alleles in Arab population (2021)

The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.
Clinical Applications of Gamma Delta T Cells with Multivalent Immunity (2014)

γδ T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to achieve clinical benefit. Aminobisphosphonates specifically expand the Vγ9Vδ2 subset of γδ T cells and have been used in clinical trials of cancer where objective responses were detected. The Vγ9Vδ2 T cell receptor (TCR) heterodimer binds multiple ligands and results in a multivalent attack by a monoclonal T cell population. Alternatively, populations of γδ T cells with oligoclonal or polyclonal TCR repertoire could be infused for broad-range specificity. However, this goal has been restricted by a lack of applicable expansion protocols for non-Vγ9Vδ2 cells. Recent advances using immobilized antigens, agonistic monoclonal antibodies (mAbs), tumor-derived artificial antigen presenting cells (aAPC), or combinations of activating mAbs and aAPC have been successful in expanding gamma delta T cells with oligoclonal or polyclonal TCR repertoires. Immobilized major histocompatibility complex Class-I chain-related A was a stimulus for γδ T cells expressing TCRδ1 isotypes, and plate-bound activating antibodies have expanded Vδ1 and Vδ2 cells ex vivo. Clinically sufficient quantities of TCRδ1, TCRδ2, and TCRδ1(neg)TCRδ2(neg) have been produced following co-culture on aAPC, and these subsets displayed differences in memory phenotype and reactivity to tumors in vitro and in vivo. Gamma delta T cells are also amenable to genetic modification as evidenced by introduction of αβ TCRs, chimeric antigen receptors, and drug-resistance genes. This represents a promising future for the clinical application of oligoclonal or polyclonal γδ T cells in autologous and allogeneic settings that builds on current trials testing the safety and efficacy of Vγ9Vδ2 T cells.
Complete Genome Sequence of Proteus mirabilis Phage Mydo (2019)

<i>Proteus mirabilis</i> is a pathogen that has been linked to nosocomial infections. Studies on phages infecting <i>P. mirabilis</i> may provide therapeutics for infections caused by antibiotic-resistant strains of this pathogen. Here, we announce the complete genome sequence of a <i>P. mirabilis</i> myophage, Mydo, which is distantly related to <i>Escherichia coli</i> phage rv5.
Rate distortion theorem and the multicritical point of a spin glass (2020)

A spin system can be thought of as an information coding system that transfers information of the interaction configuration into information of the equilibrium state of the spin variables. Hence it can be expected that the relations between the interaction configuration and equilibrium states are consistent with the known laws of information theory. We show that Shannon's rate distortion theorem can be used to obtain a universal constraint on neighboring spin correlations for a broad range of Ising spin systems with two-body spin interactions. Remarkably, this constraint gives a bound for the multicritical point in the phase diagram, when a mean-field behavior for the neighboring spin pairs can be expected in the paramagnetic phase.
Obsessive-compulsive disorder related disorders (1996)

Obsessive-compulsive spectrum disorders comprise a unique category of related disorders with important diagnostic, aetiological and therapeutic implications. This group of disorders may overlap with obsessive-compulsive disorder (OCD) in symptomatic profile, demographics, family history, neurobiology, comorbidity, clinical course and response to selective anti-obsessional behavioural and pharmacotherapies. OCD-related disorders can be viewed along a continuum with risk avoidance on the compulsive end and risk seeking at the other. This dimension may be defined within a framework which relates hyperfrontality and increased serotonergic sensitivity with compulsive disorders and hyperfrontality and low presynaptic serotonergic levels with impulsive disorders. Most biological models of OCD-related disorders stress the importance of serotonin in their pathophysiology and these disorders have also been shown to be preferentially responsive to selective serotonergic reuptake inhibitors (SSRIs). This paper reviews the management of the OCD spectrum and the evidence for efficacy of the SSRIs and the differential treatment responses of the compulsive and impulsive disorders with regard to therapeutic dosage, response lag time and maintenance of symptom remission.
Reactive Semantic Planning in Unexplored Semantic Environments Using Deep Perceptual Feedback (2020)

This letter presents a reactive planning system that enriches the topological representation of an environment with a tightly integrated semantic representation, achieved by incorporating and exploiting advances in deep perceptual learning and probabilistic semantic reasoning. Our architecture combines object detection with semantic SLAM, affording robust, reactive logical as well as geometric planning in unexplored environments. Moreover, by incorporating a human mesh estimation algorithm, our system is capable of reacting and responding in real time to semantically labeled human motions and gestures. New formal results allow tracking of suitably non-adversarial moving targets, while maintaining the same collision avoidance guarantees. We suggest the empirical utility of the proposed control architecture with a numerical study including comparisons with a state-of-the-art dynamic replanning algorithm, and physical implementation on both a wheeled and legged platform in different settings with both geometric and semantic goals.
A reconfigurable dual notched-band UWB antenna (2015)

A novel reconfigurable dual notched-band UWB antenna is presented. The antenna has an available impedance bandwidth from 3 to 11 GHz with dual band-notched characteristics centred at 3 GHZ and 5 GHZ, respectively. Meanwhile the notched-band frequency can be continuously tunable within a certain range by changing the voltage on the varactor diodes in the u-shaped slots. Finally, Antenna prototype is successfully fabricated and measured. The measured results have a good agreement with the simulated results. The proposed antenna can filter the WiMAX/WLAN band and other similar frequency bands in the rage of 3-6GHZ, according to actual application scenarios. Thus, the antenna is expected to be a good candidate in various UWB systems.
May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients? (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by vasoconstriction and widespread pulmonary micro thrombi. As a result, due to the destruction of nitric oxide (<sup>•</sup>NO) by inflammatory superoxide (O<sub>2</sub><sup>•-</sup>), pulmonary <sup>•</sup>NO concentration ceases, resulting in uncontrolled platelet aggregation and massive thrombosis, which kills the patients. Introducing <sup>•</sup>NO by inhalation (INO) may replace the loss of endothelium-derived <sup>•</sup>NO. The first results from clinical trials with INO in SARS-CoV-2 patients show a rapid and sustained improvement in cardiopulmonary function and decreased inflammation. An ongoing phase III study is expected to confirm the method's efficacy. INO may hence become a first line treatment in SARS-CoV-2 patients. However, due to the rapid inactivation of <sup>•</sup>NO by deoxyhemoglobin to nitrate, pulmonary administration of <sup>•</sup>NO will not protect remote organs. Another INO-related pharmacological approach to protect SARS-CoV-2 patients from developing life-threatening disease is to inhibit the O<sub>2</sub><sup>•-</sup>-driven destruction of <sup>•</sup>NO by neutralizing inflammatory O<sub>2</sub><sup>•-</sup>. By making use of low molecular weight compounds that mimic the action of the enzyme manganese superoxide dismutase (MnSOD). The MnSOD mimetics of the so-called porphyrin type (e.g., AEOL 10150), salen type (e.g., EUK-8) and cyclic polyamine type (e.g., M40419, today known as GC4419 and avasopasem manganese) have all been shown to positively affect the inflammatory response in lung epithelial cells in preclinical models of chronic obstructive pulmonary disease. The Manganese diPyridoxyL EthylDiamine (MnPLED)-type mangafodipir (manganese dipyridoxyl diphosphate-MnDPDP), a magnetic resonance imaging (MRI) contrast agent that possesses MnSOD mimetic activity, has shown promising results in various forms of inflammation, in preclinical as well as clinical settings. Intravenously administration of mangafodipir will, in contrast to INO, reach remote organs and may hence become an important supplement to INO. From the authors' viewpoint, it appears logical to test mangafodipr in COVID-19 patients at risk of developing life-threatening SARS-CoV-2. Five days after submission of the current manuscript, Galera Pharmaceuticals Inc. announced the dosing of the first patient in a randomized, double-blind pilot phase II clinical trial with GC4419 for COVID-19. The study was first posted on ClinicalTrials.gov (Identifier: NCT04555096) 18 September 2020.
EGFR Inhibitors Plus Bevacizumab are Superior Than EGFR Inhibitors Alone as First-Line Setting in Advanced NSCLC With EGFR Mutations and BIM Deletion Polymorphisms (BIM-CLICaP) (2021)

EGFR-TKIs plus Bev conferred a significantly higher ORR and PFS in advanced NSCLC patients with EGFR mutation and BIMdel. Further prospective studies are needed to validate these findings.
Supplementary Table A2 from Increased Plasma Soluble uPAR Level Is a Risk Marker of Respiratory Cancer in Initially Cancer-Free Individuals (2023)

Supplementary Table A2 from Increased Plasma Soluble uPAR Level Is a Risk Marker of Respiratory Cancer in Initially Cancer-Free Individuals
Reduced Rough-Surface Parameterization for Use With the Discrete-Element Model (2007)

The discrete-element model for flows over rough surfaces was recently modified to predict drag and heat transfer for flow over randomly-rough surfaces. However, the current form of the discrete-element model requires a blockage fraction and a roughness-element diameter distribution as a function of height to predict the drag and heat transfer of flow over a randomly-rough surface. The requirement for a roughness element-diameter distribution at each height from the reference elevation has hindered the usefulness of the discrete-element model and inhibited its incorporation into a computational fluid dynamics (CFD) solver. To incorporate the discrete-element model into a CFD solver and to enable the discrete-element model to become a more useful engineering tool, the randomly-rough surface characterization must be simplified. Methods for determining characteristic diameters for drag and heat transfer using complete three-dimensional surface measurements are presented. Drag and heat transfer predictions made using the model simplifications are compared to predictions made using the complete surface characterization and to experimental measurements for two randomly-rough surfaces. Methods to use statistical surface information, as opposed to the complete three-dimensional surface measurements, to evaluate the characteristic dimensions of the roughness are also explored.
Dispersion‐free solvent extraction with microporous hollow‐fiber modules (1988)

Abstract Extensive studies on dispersion‐free solvent extraction have been carried out using modules made with either hydrophobic or hydrophilic microporous hollow‐fiber membranes. Membrane and boundary layer resistances have been characterized for both kinds of hollow fiber using solvent extraction systems with a wide variation of distribution coefficients and interfacial tensions. It has been found that the Graetz solution for a constant wall concentration describes satisfactorily mass transfer on the lumen side of a hollow‐fiber device. A correlation of the form N Sh = [ D h (1 − ϕ)/ L ] N N appears to provide a close fit to the shell‐side mass transfer coefficient data. The perforamnce characteristics of dispersion‐free extraction in hollow‐fiber modules have been considered against those of commercial packed‐bed extractors. A perspective has been provided on comparative utilities of hydrophobic or hydrophilic hollow fibers for a given solvent extraction problem.
CELL POLARITY AND MORPHOGENESIS IN BUDDING YEAST (1998)

Eukaryotic cells respond to intracellular and extracellular cues to direct asymmetric cell growth and division. The yeast Saccharomyces cerevisiae undergoes polarized growth at several times during budding and mating and is a useful model organism for studying asymmetric growth and division. In recent years, many regulatory and cytoskeletal components important for directing and executing growth have been identified, and molecular mechanisms have been elucidated in yeast. Key signaling pathways that regulate polarization during the cell cycle and mating response have been described. Since many of the components important for polarized cell growth are conserved in other organisms, the basic mechanisms mediating polarized cell growth are likely to be universal among eukaryotes.
Spatial frequency-based microbending fiber optic sensor (2002)

A new approach to fiber optic microbending sensors is demonstrated, where the spatial frequency of the bends, not the amplitude, is varied. This paper shows how to design this sensor, including the effect on sensitivity due to number of bends, bend amplitude, and deformation shape. By prebending the optical fiber into a series of bends, and then embedding it into a compliant material, we created a sensor whose spatial frequency can be changed by compressing the material. Results from our prototype exhibited the predicted transmission loss by alternating bend spacing. Due to the resonant nature of the mode-coupling effect, this modified sensor has the capability of equating to sensitivity levels found in the human finger tip. The application for the quartz industry is to use this sensor to automate those crystal processes which are currently restricted solely to manual means.
A magnetic recording tape based on iron particles (1973)

Tapes based on acicular iron particles give an outstanding recording performance compared to γ-Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> and CrO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> tapes. Especially in the short wavelength region the signal to noise ratio is, respectively, 12 and 7 dB better, whereas the bias noise level is somewhat lower. The iron tapes have a high coercivity, between 80 and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">90 \times 10^{3}</tex> A/m, and hence the required bias is about 9 dB higher than for γ-Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> . The print through properties are excellent.