gebhart/patrepeval huggingface dataset:
ICAM-1 ANTISENSE OLIGODEOXYNUCLEOTIDE BLOCKS KIDNEY ALLOGRAFT REJECTION IN CYNOMOLGUS MONKEYS (1998)

22 Introduction: We previously showed that the combination of rat-specific intracellular adhesion molecule-1 (ICAM-1) IP-9125 phosphorothiate antisense oligodeoxynucleotides (PT-oligo) with cyclosporine (CsA) synergistically prolonged the survival of heart and kidney allografts in rats. The present study examined the in vivo effect of monkey- or human-specific ICAM-1 PT-oligo to block kidney allograft rejection in cynomolgus monkeys. Methods: Selected monkey-specific IP-10984 or human-specific IP-2302 ICAM-1 antisense PT-oligo (but not scrambled controls) inhibited both ICAM-1 protein and ICAM-1 mRNA expression in monkey endothelial cells. Donor/recipient pairs were pre-selected using a one-way mixed lymphocyte reaction (MLR) to determine the proliferation index values (PIV): those recipients with PIV of 7-25 against donor alloantigens were considered low and those with PIV of 30-221 were considered high responders. Recipients were treated daily with CsA adjusted to whole blood levels of 40-200 ng/ml (subtherapeutic) or 200-400 ng/ml (therapeutic). In experimental groups, high responder recipients were treated with therapeutic CsA course alone or in combination with 5.0 mg/kg/day IP-10984 delivered daily by a 2-hour intravenous (i.v.) infusion initiated on the day of transplantation. Low responder recipients were treated with subtherapeuthic CsA course alone or with therapeutic CsA course in combination with IP-2302 which was initiated after stabilization of kidney transplant function (day 30-45 postgrafting). Results: Although high responder recipients treated with therapeutic CsA course (10-35 mg/kg) produced whole blood trough levels of 200-400 ng/ml, they rejected kidney allograft at a mean survival time (MST) of 21.0±8.6 days (n=3). Addition of 5.0 mg/kg/day IP-10984 delivered from the day of grafting to the therapeutic CsA therapy prolonged allograft survivals to 42.8±23.6 (ranging 29-78 days; n=4). Subtherapeutic CsA monotherapy (2-10 mg/kg) of low responders did not prolong the survival of kidney allografts (8.0±1.0 days; n=3). In contrast three low responder recipients treated with therapeutic CsA doses displayed stable kidney function 30-45 days posgrafting. These recipients were treated with CsA and daily 5.0 mg/kg PT-2302 for 7 days and CsA therapy was completely withdrawn within 14 days; hence they remained on IP-2302 alone for the next 60 days. All recipients on IP-2302 monotherapy displayed normal kidney function (creatinine 0.6-0.9 mg/dl). Furthermore, after IP-2302 was withdrawn two recipients survived for 24 months with normal kidney function. Conclusions: Monkey- or human-ICAM-1 antisense oligo specifically inhibits ICAM-1 protein expression in vitro in monkey cells, and blocks allograft rejection in vivo when used for postoperative therapy or for maintenance of immunosuppression.
Coherent Hole Transport in Selective Area Grown Ge Nanowire Networks (2022)

Holes in germanium nanowires have emerged as a realistic platform for quantum computing based on spin qubit logic. On top of the large spin-orbit coupling that allows fast qubit operation, nanowire geometry and orientation can be tuned to cancel out charge noise and hyperfine interaction. Here, we demonstrate a scalable approach to synthesize and organize Ge nanowires on silicon (100)-oriented substrates. Germanium nanowire networks are obtained by selectively growing on nanopatterned slits in a metalorganic vapor phase epitaxy system. Low-temperature electronic transport measurements are performed on nanowire Hall bar devices revealing high hole doping of ∼10<sup>18</sup> cm<sup>-3</sup> and mean free path of ∼10 nm. Quantum diffusive transport phenomena, universal conductance fluctuations, and weak antilocalization are revealed through magneto transport measurements yielding a coherence and a spin-orbit length of the order of 100 and 10 nm, respectively.
Niobium & Tantalum: Inorganic & Coordination Chemistry (2005)

Abstract The chemistry of niobium and tantalum ranges from oxidation states +V to −III with no species of oxidation state −II known so far. The chemistry of those oxophilic metals is dominated by their highest oxidation states, V and IV. Pentahalides especially chlorides are the most usual starting material. They form numerous complexes especially with hard donors and are used for access not only to pentavalent metal alkoxides, amides, thiolates, and so on but also to most molecular species in lower oxidation states. Oxo species are formed quite easily by O‐donor abstraction reactions or adventitious hydrolysis. Pentavalent alkoxides are active in various catalytic processes and are useful precursors for access to oxide ceramics such as ferroelectrics via the formation of heterometallic species. The most relevant results in organometallic chemistry of Nb and Ta have been obtained with ancillary, bulky aryloxide or siloxide ligands. Niobium is more prone to reduction than tantalum. Chalcogenides and chalcogenohalides are often one–dimensional solids and display a rich structural and synthetic chemistry. Numerous trispyrazolylborate derivatives of Nb and Ta have been reported for oxidation states V to I. The development of the nonaqueous chemistry of those elements in intermediate oxidation states has become an active and fruitful area. Species based on MM or MM multiple bonds, the latter especially for Nb, have been characterized. The NbNb triple bond (2.20 Å) is much shorter than the MM distance in the metal. Tri‐ or divalent species are able to promote CE (E = O, S, N) cleavage and thus to generate novel ligands because of the trend of Nb and Ta to form multiple ME bonds and attain their highest oxidation states. CC coupling reactions are observed with unsaturated ligands (alkynes, nitriles, etc.). M III η 2 ‐alkyne complexes have a metallocyclopropene character; they can react with unsaturated organic molecules via stoichiometric reactions. The reservoir of electrons of the MM bond is also of interest for activation of small molecules such as N 2 , H 2 , CO, and so on. Tri or tetradentate N,N; N,P; or N,O ligands have been used to stabilize dimeric dia or paramagnetic dinitrogen complexes. The bridging, highly activate N 2 ligand is amenable to functionalization in some cases, and cleavage into nitrides has been observed. The chemistry of reduced Nb and Ta halides is rich in clusters with nonintegral oxidation states (between III and I). Hexanuclear clusters dominate the aqueous chemistry for these oxidation states. One of their potential applications could be their use as contrasting agents. The species in the lowest oxidation states are essentially based on carbonyl ligands.
The effect of nanoparticle softness on the interfacial dynamics of a model polymer nanocomposite (2022)

The introduction of soft organic nanoparticles (NPs) into polymer melts has recently expanded the material design space for polymer nanocomposites, compared to traditional nanocomposites that utilize rigid NPs, such as silica, metallic NPs, and other inorganic NPs. Despite advances in the fabrication and characterization of this new class of materials, the effect of NP stiffness on the polymer structure and dynamics has not been systematically investigated. Here, we use molecular dynamics to investigate the segmental dynamics of the polymer interfacial region of isolated NPs of variable stiffness in a polymer matrix. When the NP-polymer interactions are stronger than the polymer-polymer interactions, we find that the slowing of segmental dynamics in the interfacial region is more pronounced for stiff NPs. In contrast, when the NP-polymer interaction strength is smaller than the matrix interaction, the NP stiffness has relatively little impact on the changes in the polymer interfacial dynamics. We also find that the segmental relaxation time τ<sub>α</sub> of segments in the NP interfacial region changes from values lower than to higher than the bulk material when the NP-polymer interaction strength is increased beyond a "critical" strength, reminiscent of a binding-unbinding transition. Both the NP stiffness and the polymer-surface interaction strength can thus greatly influence the relative segmental relaxation and interfacial mobility in comparison to the bulk material.
Improvements of a dual-input DBN for noise robust ASR (2011)

\n Contains fulltext :\n 94477.pdf (Publisher’s version ) (Open Access)\n
Method for increasing the photoconductive response in conjugated polymer/fullerene composites (2006)

The authors poly(3-hexylthiophene)/[6,6]-phenyl C61-butyric acid methyl ester present a technique for modifying the internal structure of bulk heterojunction films which yields significantly improved photoconductivity. This method comprises the addition of alkyl thiol molecules to the polymer/fullerene solution prior to spin coating. Based on the steady-state and transient photoconductivity measurements, the photoresponsivity is an order of magnitude greater than that in films spun from pristine solvent; additionally, the carrier mobility measurements indicate significant increase in the hole mobility, consistent with the enhanced structural order inferred from x-ray diffraction and optical absorption measurements.
Situationseröffnungen : zur multimodalen Herstellung fokussierter Interaktion (2010)

Der Band führt aus einer multimodalen Perspektive in die Analyse von Situationseröffnungen ein. Auf der Grundlage von Videoaufzeichnungen unterschiedlicher sozialer Situationen analysiert er die multimodalen Verfahren, mit denen die Beteiligten sich schrittweise auf eine koordinierte Interaktion orientieren, diese vorbereiten und schließlich herstellen. Kontrastiv zu etablierten Untersuchungen verbaler Gesprächseröffnungen am Telefon wird das spezifische Anforderungsprofil der multimodalen Situationsherstellung verdeutlicht. Der Band enthält sechs empirische Untersuchungen verschiedener Situationstypen: Filmset, Arbeitssitzungen, Videokonferenzen, Raclette- Essen unter Bekannten, Wegauskünfte, zufällige Treffen im Supermarkt und ein Gottesdienstanfang. Die Analysen fokussieren die für den jeweiligen Situationstyp konstitutiven Aspekte der Situationseröffnung: die von den Interaktionsbeteiligten gemeinsam hergestellte Ordnungsstruktur, deren sequenzielle und segmentale Spezifik, das interaktive Anforderungsprofil und die eingesetzten multimodalen Verfahren. Neben der Dichte simultan stattfindender Koordinationsleistungen wird in den Beiträgen vor allem die Bedeutung derjenigen Interaktionsprozesse hervorgehoben, die der Herauslösung und Vorbereitung der Situation dienen und der formellen Eröffnung vorausgehen. Die Untersuchungen verweisen so ganz grundsätzlich auf die Relevanz "interaktiver Vorgängigkeit"
Biocidal Efficacy of Non-Equilibrium Plasma Sources: A Comparative Study (2018)

Disinfecting foods and their contact surfaces is imperative to agriculture and food-processing industries. There is compelling rationale in employing atmospheric pressure plasmas for decontamination as they enable the treatment of heat-sensitive materials at ambient conditions. By producing a chemically rich environment, non-equilibrium plasma discharges are tremendously effective in the inactivation of bacteria and viruses. The in-situ generation of reactive oxygen and nitrogen species (RONS) eliminates the need for chemicals and makes it a green technology.
Het algemeen onderzoek (2015)

Het lichamelijk onderzoek begint met een algemene inspectie. Let hierbij op: de lichaamsbouw (pycnisch, atletisch, leptosoom?) (zie paragraaf Lichaamsbouw); de voedingstoestand (zie paragraaf De voedingstoestand); de psychische toestand (nerveus, angstig, depressief?) (zie paragraaf De gemoedstoestand); het bewustzijn (bijvoorbeeld Glasgow Coma Scale) (zie paragraaf De bewustzijnsgraad); de mate van ziek-zijn (zie paragraaf Hoe ziek is de patiënt?); mogelijke uitdroging (zie paragraaf Is de patiënt uitgedroogd?); de beharing (zie paragraaf Beharing); de huid (zie paragraaf De huidskleur): kleur: bleek, cyanose, icterus? oedeem? efflorescenties? bloedingen? de ademhaling (zie paragraaf De ademhaling): frequentie; diepte; ritme; de inspanning die het kost; de productie van geluid tijdens inspirium en exspirium. Verder worden de volgende metingen gedaan: de lichaamstemperatuur (zie hoofdstuk 6, paragraaf De lichaamstemperatuur); de lengte en het gewicht (zie hoofdstuk 6, paragraaf Lengte en gewicht); de arteriële bloeddruk (zie hoofdstuk 6, paragraaf De arteriële bloeddruk); de pols (zie hoofdstuk 7, paragraaf De pols); de centraalveneuze druk (zie hoofdstuk 6, paragraaf De centraalveneuze druk).
Proportion of Injured Drivers Presenting to a Tertiary Care Emergency Department Who Engage in Future Impaired Driving Activities (2010)

A high portion of injured impaired drivers who present to hospital engage in repeat IDA following discharge. Besides impairment at time of hospital visit, the best predictor of future IDA is a history of IDA prior to the index event.
Synthesis And Antioxidant Activity Of Galloyltyrosine, Derivatives From Young Leaves Of Inga Laurina (2011)

Synthesis of Galloyltyrosine and its derivatives 9a-e and 13a-c was achieved from appropriately substituted benzoic acid and L-tyrosine. While compounds 9a-e and 13a-c was exhibited potent antioxidant activity in both the NBT and DPPH – radical scavenging models among the synthesized Galloyltyrosine derivatives. K. RAMANJANEYULU
Serum biomarkers in interstitial lung diseases (2005)

The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The past fifteen years have seen the emergence of numerous clinical applications of several new molecules as biologic markers in the research field relevant to interstitial lung diseases (translational research). The scope of this review is to summarize the current state of knowledge about serum biomarkers in interstitial lung diseases and their potential value as prognostic and diagnostic tools and present some of the future perspectives and challenges.
Conjunctival Squamous Cell Neoplasia Associated With Ocular Cicatricial Pemphigoid (2017)

The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. One patient had a preinvasive squamous dysplasia and the other an invasive squamous cell carcinoma, both in the unequivocal setting of OCP with bilateral conjunctivitis, symblephara, and forniceal foreshortening. The patients had been receiving intensive immunotherapy consisting of some combination of corticosteroids, rituximab, and interferon alpha. Both patients had a positive immunofluorescent study demonstrating immunoreactants at the level of the epithelial basement membrane. Each patient had 2 earlier negative immunofluorescent studies before a third was positive. While rare, there is 1 previous report of an association between OCP and conjunctival squamous neoplasia. The current report provides more data supporting the proposal that this conjunction is more than a random event. Repeat immunofluorescent studies after an initial negative result in a patient with strong clinical signs of OCP are imperative due to the frequency of false negative studies in the context of clinically persuasive disease.
Probability of adverse events that have not yet occurred: a statistical reminder (1995)

The probability of adverse and undesirable events during and after operations that have not yet occurred in a finite number of patients (n) can be estimated with Hanley's simple formula, which gives the upper limit of the 95% confidence interval of the probability of such an event: upper limit of 95% confidence interval = maximum risk = 3/n (for n > 30). Doctors and surgeons should keep this simple rule in mind when complication rates of zero are reported in the literature and when they have not (yet) experienced a disastrous complication in a procedure.
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. (2000)

Tumor Necrosis Factor (TNF) is a cytokine that induces necrotic and apoptotic forms of cell death. The TNF-induced signalling mechanisms leading to necrosis or apoptosis are partially distinct, and are therefore likely to be regulated in a different way. The zinc finger protein A20 is a TNF-induced primary response gene that has been shown to inhibit TNF-induced apoptosis. However, its ability to inhibit the necrotic route of cell death as well as the underlying mechanism remains unknown. Here we show that stable expression of A20 or a fusion protein consisting of Green Fluorescent Protein (GFP) and A20 protects the TNF-sensitive fibroblast cell line L929 partially from TNF-induced necrotic cell death. TNF-induced necrosis has been shown to involve the activation of several phospholipases, as well as an increased production of reactive oxygen radicals. The reduced TNF-sensitivity of A20-expressing L929 cells was correlated with a decrease of TNF-induced phospholipase A2 (PLA2), phospholipase C (PLC) and phospholipase D (PLD) activation. Furthermore, production of mitochondrial reactive oxygen intermediates was retarded by overexpression of A20. These results demonstrate that A20 not only inhibits TNF-induced apoptosis but also TNF-induced necrosis, suggesting that it interferes with an early step in TNF signalling which is required for both types of cell death.
High-precision optical phase-locking based on wideband acousto-optical frequency shifting (2014)

We present a high-precision optical phase-locking based on wideband acousto-optical frequency shifting. Increasing the modulating bandwidth stabilizes the loop at a high loop gain, thus improving phase correction capability. An optical phase-locked loop with a wide control bandwidth is constructed. The closed-loop residual phase error is only 0.26 or smaller than /1000. The loop exhibits excellent correction capability for high-frequency noises. The correctable frequency range reaches 35 kHz when the noise amplitude is /2, and becomes even wider for smaller noise amplitudes.
Performance of the lithium metal infused trenches in the magnum PSI linear plasma simulator (2015)

The application of liquid metal, especially liquid lithium, as a plasma facing component (PFC) has the capacity to offer a strong alternative to solid PFCs by reducing damage concerns and enhancing plasma performance. The liquid-metal infused trenches (LiMIT) concept is a liquid metal divertor alternative which employs thermoelectric current from either plasma or external heating in tandem with the toroidal field to self-propel liquid lithium through a series of trenches. LiMIT was tested in the linear plasma simulator, Magnum PSI, at heat fluxes of up to 3 MW m-2. Results of these experiments, including velocity and temperature measurements, as well as power handling considerations are discussed, focusing on the 80 shots performed at Magnum scanning magnetic fields and heat fluxes up to ∼0.3 T and 3 MW m-2. Comparisons to predictions, both analytical and modelled, are made and show good agreement. Concerns over MHD droplet ejection are additionally addressed.
OPTICAL COUPLING OF ADJACENT STRIPE-GEOMETRY JUNCTION LASERS (1970)

The observation of coupling and consequent coherent operation of two adjacent parallel stripe-geometry GaAs lasers in a monolithic structure is reported. Coupling is obtained when the distance between the lasers is small enough to allow the optical field of one laser to penetrate into the active region of the other.
Pharmacotherapies for obstructive sleep apnea: how close are we? (2001)

Obstructive sleep apnea is a prevalent disorder associated with significant neurobehavioral and cardiovascular morbidities. At present, however, there are no widely effective, well-tolerated pharmacotherapies for obstructive sleep apnea. The pathogenesis of this disorder predicts that sleep apnea should respond to drug therapies. Specifically, respiration during waking in persons with sleep apnea is normal, while collapse of the upper airway occurs exclusively in sleep. This state-dependency in upper airway patency suggests state-dependent changes in neurochemical control of the upper airway dilator motoneurons, and this, in turn, suggests that appropriate medications would maintain upper airway dilator function in sleep and prevent sleep related collapse of the upper airway. The past few years have brought significant insight into the neural mechanisms governing upper airway dilator muscle function. This article provides updates on neurochemical mechanisms, emphasizing a role for serotonergic control, and reviews recent drug therapy trials for sleep apnea. We are currently well poised to develop effective pharmacotherapies for obstructive sleep apnea, with opportunities to target several regions involved in respiratory control.
Variability of pepper veinal mottle potyvirus isolates and their impact on breeding for resistance in peppers (2001)

* INRA Documentation, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9 Diffusion du document : INRA Documentation, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9
Synovial distribution of αd/CD18, a novel leukointegrin. Comparison with other integrins and their ligands (1996)

The leukointegrin alpha d/CD18 is expressed constitutively by synovial macrophages and macrophage-like lining cells. In rheumatoid synovitis, the intense coexpression of this integrin and its known counter-receptor, ICAM-3, in the inflammatory infiltrates, suggests a potential role for this adhesion pathway in cellular interactions occurring the synovium.
A Case of Acute Myeloid Leukemia with Mediastinal Sarcoma (2009)

Myeloid sarcoma (MS) is a solid extramedullary tumor that is composed of immature myeloid cells. The incidence of MS in patients with acute myeloid leukemia (AML) has been reported to be 3∼8%. Lymph nodes are the most frequent site of presentation for MS, and other clinical presentations such as an abdominal mass with bowel involvement, a pancreatic mass, isolated central nervous system infiltration, a testicular mass and breast lumps have also been reported. AML with mediastinal MS is a relatively rare disease. The patients with AML with mediastinal MS has been reported to have complex cytogenetic abnormalities and a poor long-term prognosis. The optimal treatment of AML with MS remains to be determined. We report here on an unusual case of a 37-year-old man who presented multiple lymph node enlargements on the neck and a huge mediastinal mass that was considered to be lymphoma. He was finally diagnosed as AML with MS according to the surgical excisional biopsy of a left supraclavicular lymph node and bone marrow examination. He achieved complete remission and the multiple enlarged lymph nodes on the neck and the mediastinal mass disappeared after remission induction chemotherapy. Thereafter, he received HLA-matched unrelated allogenic hematopoietic stem cell transplantation.