gebhart/patrepeval huggingface dataset:
β-Hydroxyphenethylamino Derivatives of Various Nitrogen Heterocycles (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTβ-Hydroxyphenethylamino Derivatives of Various Nitrogen HeterocyclesDonald E. Heitmeier and Allan P. GrayCite this: J. Med. Chem. 1964, 7, 3, 288–293Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 May 1964https://pubs.acs.org/doi/10.1021/jm00333a009https://doi.org/10.1021/jm00333a009research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
THE AMINO ACID COMPOSITION AND C-TERMINAL SEQUENCE OF A CHEMICALLY EVOKED MUTANT OF TMV (1960)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Targeting urokinase-type plasminogen activator and its receptor for cancer therapy (2006)

Cancer invasion and metastasis are highly complex processes and a serine protease urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system has been postulated to play a central role in the mediation of cancer progression. Of note, malignant tumor urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor levels have been found to vary considerably, and to be related to patient prognosis. In mouse models, the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system has been studied extensively as a target for anticancer therapy using a variety of approaches. In this review, we discuss the advances in the various modalities that have been used to target the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system, including protein-based and peptide-based drugs, antisense therapy, and RNA interference technology. In particular, preclinical mouse model studies that used human tumor xenografts are reviewed.
Immunogenicity of two formulations of oral cholera vaccine comprised of killed whole vibrios and the B subunit of cholera toxin (1989)

Two formulations of oral cholera vaccine were evaluated for safety and immunogenicity in adult volunteers in Thailand, an area with sporadic cholera outbreaks. One formulation consisted of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit, as was previously evaluated in North American volunteers, and the other consisted of 1 x 10(11) killed vibrios and 1 mg of B subunit, as was recently evaluated in a field trial in Bangladesh. Three doses of each formulation were given with citrate-bicarbonate buffer. Neither formulation had adverse effects. The formulations stimulated similar serum immunoglobulin G (IgG) and IgA responses to Vibrio cholerae lipopolysaccharide and cholera toxin and intestinal secretory IgA responses to lipopolysaccharide and toxin after three doses. The formulation containing twice the quantity of killed vibrios stimulated better vibriocidal responses, especially to Ogawa serotype. A formulation of oral vaccine containing more killed vibrios than were included in the vaccine studied in the Bangladesh field trial may provide greater protection against cholera.
Influence of drilled holes on bending properties of compressed wood manufactured by new process. (2008)

In previous research on the compressive deformation process using a closed heating system, we examined a new process characterized by drilling holes into wood. In this research, we clarified the influence of drilled holes on the bending properties of wood. The equilibrium moisture content (EMC) of compressed wood that was steam treated was 6 to 7 percent. The EMC of compressed wood prepared by the simultaneous process of compression drying and deformation fixation was 8 percent. The modulus of rupture (MOR) and modulus of elasticity (MOE) of compressed wood with drilled holes were lower than those of compressed wood without drilled holes. This decrease was caused by the decrease in the section modulus (or moment of inertia) and the stress concentration around the drilled holes. The MOR and MOE decreases due to the drilled holes were about 18 percent and 15 to 22 percent, respectively. The specific deflection energy was defined, and samples were evaluated quantitatively. The value for compressed wood prepared by the simultaneous process of compression drying and deformation fixation was higher than for those of other samples.
Narrow bandwidth resonances in periodic plasmonic structures (2014)

Narrow bandwidth resonances (NBR) in the region of Wood anomaly in symmetric and asymmetric refractive index environment for different system configurations are studied. Coupled plasmonic nanonanoresonators system and its optical response is considered numerically and using simple analytical model. Crucial role of the substrate influence on the NBR for various configurations is thoroughly investigated. Possible prospective designs for particular experimental realization are suggested and discussed.
Angular-dependent vortex pinning mechanism in YBa2Cu3O7−δ/YSZ quasi-multilayer (2008)

The temperature and magnetic field dependences of anisotropic pinning contributions of YBa2Cu3O7−δ/YSZ quasi-multilayer have been investigated by the measurement of angular-dependent critical current density (Jc). With the isotropic and anisotropic pinning contributions in a wide range of temperature, we identify the possible sources of the pinning centers and classify them into the weak and the strong flux pinning model. Angular-dependent Jc(H,T) measurements have demonstrated that the growth control strategy is very effective in preventing the vortex motion at high fields and high temperatures. It is suggested that at high applied fields, such as 7 T, the pinning contribution of the nanostructured quasi-multilayers is dominated by the anisotropic disorders, while at intermediate-low fields (such as 1 T) the pinning contribution is determined by both isotropic and anisotropic disorders, suggesting the coexistence of isotropic and anisotropic pinning.
Autonomous navigation of a mobile robot using custom-designed qualitative reasoning VLSI chips and boards (2003)

Two types of computer boards including custom-designed VLSI chips have been developed to add a qualitative reasoning capability to the real-time control of autonomous mobile robots. The design and operation of these boards are first described, and an example of their use for the autonomous navigation of a mobile robot is presented. The development of qualitative reasoning schemes emulating human-like navigation in a priori unknown environments is discussed. The efficiency of such schemes, which can consist of as little as a dozen qualitative rules, is illustrated in experiments involving an autonomous mobile robot navigating on the basis of very sparse and inaccurate sensor data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Transmission between HIV-infected patients of multidrug-resistant tuberculosis caused by Mycobacterium bovis (1997)

The use of centralized DNA databases can help to identify rapidly the origin and transmission routes of multidrug-resistant TB across international boundaries and the potential use of such an early warning surveillance system for investigation of nosocomial multidrug-resistant TB outbreaks between HIV-infected patients. To our knowledge this is the first report of transmission of multidrug-resistant M. bovis between hospitals.
An Automated Tool for Generating UML Models from Natural Language Requirements (2009)

This paper describes a domain independent tool, named, UML Model Generator from Analysis of Requirements (UMGAR), which generates UML models like the Use-case Diagram, Analysis class model, Collaboration diagram and Design class model from natural language requirements using efficient Natural Language Processing (NLP) tools. UMGAR implements a set of syntactic reconstruction rules to process complex requirements into simple requirements. UMGAR also provides a generic XMI parser to generate XMI files for visualizing the generated models in any UML modeling tool. With respect to the existing tools in this area, UMGAR provides more comprehensive support for generating models with proper relationships, which can be used for large requirement documents.
Arabinogalactan proteins have deep roots in eukaryotes: identification of genes and epitopes in brown algae and their role in Fucus serratus embryo development (2015)

Arabinogalactan proteins (AGPs) are highly glycosylated, hydroxyproline-rich proteins found at the cell surface of plants, where they play key roles in developmental processes. Brown algae are marine, multicellular, photosynthetic eukaryotes. They belong to the phylum Stramenopiles, which is unrelated to land plants and green algae (Chloroplastida). Brown algae share common evolutionary features with other multicellular organisms, including a carbohydrate-rich cell wall. They differ markedly from plants in their cell wall composition, and AGPs have not been reported in brown algae. Here we investigated the presence of chimeric AGP-like core proteins in this lineage. We report that the genome sequence of the brown algal model Ectocarpus siliculosus encodes AGP protein backbone motifs, in a gene context that differs considerably from what is known in land plants. We showed the occurrence of AGP glycan epitopes in a range of brown algal cell wall extracts. We demonstrated that these chimeric AGP-like core proteins are developmentally regulated in embryos of the order Fucales and showed that AGP loss of function seriously impairs the course of early embryogenesis. Our findings shine a new light on the role of AGPs in cell wall sensing and raise questions about the origin and evolution of AGPs in eukaryotes.
Enhanced podocalyxin expression alters the structure of podocyte basal surface (2004)

Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes). We demonstrated that GBM and laminin, but not collagen IV, up-regulated the expression of podocalyxin. Scanning electron microscopy revealed that laminin induced a modified morphology of podocytes with process formation, which was more extensive in the presence of GBM. Under high magnification, podocytes appeared ruffled. Using transmission electron microscopy we observed that raised areas occurred in the basal cell surface. Furthermore, the presence of anti-podocalyxin antibody increased the extent of adhesion and spreading of podocytes to both collagen IV and laminin, thus podocalyxin apparently inhibits cell-matrix interactions. We also performed adhesion and spreading assays on podocytes grown under increased glucose concentration (25 mM). Under these conditions, the expression of podocalyxin was almost totally suppressed. The cells adhered and spread to basement membrane components but there was no increase in the extent of adhesion and spreading in the presence of anti-podocalyxin antibody, or ruffling of the cell edges. Additionally, in podocytes expressing podocalyxin, the presence of anti-podocalyxin antibody partially reversed the inhibition of adhesion to collagen IV provoked by anti-beta1 integrin antibody, thus podocalyxin should compete with beta1-related cell adhesion. We suggest that the observed podocalyxin-mediated inhibition of binding to the matrix could be in part responsible for the specialized conformation of the basal surface of podocytes.
Change for Change (2010)

Organizational change involves the implementation of new tools, procedures or technologies in order to face challenges due to the changing demands of business, or to create new business opportunities. Change management is yet another widely debated and written about topic in management. The last couple of decades have seen managers experiencing series of radical changes at the work place. Change is a complex process-it is a response to continuously evolving conditions. The days of stable environment and relatively few changes are over. Today we have an environment where change is not only continuous but requires the management to adopt multiple strategies to meet them. Moreover, change processes have become a kind of turning point in organizations with their vast scope leaving one with the idea that it is not the change of culture one should get used to, but to the cultural changes. Change management refers to the making of changes in a planned and managed or systematic fashion. The aim is to more effectively implement new methods and systems in an on going organization.
Inward Rectifier K+ Current in Human Bronchial Smooth Muscle Cells (2002)

Inward rectifier K(+) (Kir) channels play an important role in forming membrane potential and then modulating muscle tone in certain types of smooth muscles. In cultured human bronchial smooth muscle cells (hBSMCs), Kir current was identified using whole-cell voltage clamp techniques and explored by using RT-PCR analysis of mRNA, Western blotting, and antisense oligonucleotide methods to block the synthesis of Kir channel protein. The K(+) current with strong inward rectification and high K(+) ion selectivity was observed. The current was unaffected by 4-aminopyridine, glibenclamide, and charybdotoxin, and hardly inhibited by tetraethylammonium, but was potently inhibited by extracellular Ba(2+). The IC(50) value of external Ba(2+) was approximately 1.3 microm. RT-PCR analysis of mRNA showed transcripts for Kir2.1, but not Kir1.1, Kir2.2, or Kir2.3. Treatment of cells with antisense oligonucleotides targeted to Kir2.1 resulted in a decrease in the current density of the Kir current and Kir protein expression, as compared with the mismatch-treated cells, whereas the current density of 4-AP-sensitive K(+) currents (K(V)) remained unaffected. The application of Ba(2+) markedly depolarized the membrane. These results demonstrate that Kir channel is present in human bronchial smooth muscle cells, and the Kir2.1 gene encodes the Kir channel protein in these cells.
Preheating Technique to Enhance the Laser Ablation Impulse from Polymer Materials (2011)

A novel preheating technique to enhance laser-ablative impulse is investigated. In this technique, target material is first heated to an appropriate temperature by irradiating with a continuous laser. Impulse is generated by irradiating an intense laser pulse on the preheated material. In the experiment, polymer materials are preheated simply using an electric heater to investigate the effect of the material temperature on the laser ablative impulse. A pulsed TEA CO2 pulse laser is used to generate impulse. The results demonstrate that the present technique is useful for Poly-vinyl Chloride (PVC), Acrylic resin (PMMA), and Carbon Fiber Reinforced Plastic (CFRP). The momentum coupling coefficient of PMMA has a peak at the temperature close to the glass transition temperature.
Frontispiece: Use of Dithiasuccinoyl‐Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts (2020)

The thiol-mediated reduction of dithiasuccinoyl groups was harnessed to develop a method for controlled carbonyl sulfide (COS) generation under buffered aqueous conditions. This reactivity generates two equivalents of COS and does not result in formation of electrophilic byproducts such as (imino)quinone methides. The rate of COS generation can be tuned as function of amine identity, and theoretical investigations provide key insights into COS release from thiocarbamate intermediates. For more information, see the Full Paper by M. D. Pluth and co-workers on page 5374 ff.
A simple low-cost, thermistor-based, local air-velocity mapping method (PCB modules) (2003)

A method is presented for using interchangeable thermistors as local air-velocity transducers for the thermal verification of electronic assemblies. Because of their small size, thermistors are ideally suited for local velocity measurements in hard-to-reach places, and do not interfere with the phenomena being measured. Accuracy is acceptable in the velocity range from 0 to 600 ft/min, in the ambient temperature range from 20 to 45 degrees C, and the cost is lower than that of other sensors. Because the thermistor is intrinsically a temperature sensor, it can also double as a local air-temperature transducer. Thermistor signals are high level, and therefore easier to read than those from other types of transducers such as thermocouples or transistor junctions, and no reference temperatures or precalibration are required. Used in conjunction with data logging equipment and a computer, a printed-circuit module is produced, displayed, and stored. These data are intended for use with proprietary software to predict individual board component junction temperatures and failure rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced DNA Repair Via Fanconi Anemia/BRCA Pathway Is Involved in Melphalan-Resistant Myeloma Cells. (2004)

Abstract Melphalan, a DNA crosslinker, is one of the most widely used and effective drugs in the treatment of multiple myeloma (MM). Interstrand cross-links (ICL) are amongst the most toxic types of DNA damage; therefore, DNA cross-linking agents are important drugs in cancer treatment. Unfortunately, although most patients respond to standard and high dose melphalan therapy, eventually patients acquire drug resistance. Acquired melphalan resistance has been associated with reduced DNA crosslinks, elevated levels of glutathione and increased radiation survival. However, mechanisms associated with resistance are not well understood. Evidence has accumulated to suggest that ICL repair contributes to the melphalan resistance. In this study, we compared the gene expression profile (GEP) of the melphalan-resistant myeloma cell line, 8226/LR5 to the 8226/S drug sensitive cell line, and found genes involved in FANC/BRCA DNA cross-link repair pathway had increased expression in drug resistant cells. The aim of our study was to determine whether FANC-BRCA pathway affects the DNA cross link repair capacity and accounts for acquired melphalan-resistance. Using real time RT-PCR and Western Blotting, we examined the expression levels of FANC/BRCA pathway genes in two different drug sensitive and resistant cell lines: 8226/S 8226/LR5, and U266/S and U266/LR6. The results showed that increased expression of FANC/BRCA pathway genes correlated with the melphalan resistance. The formation of ICL at 5 hours after a 2 hour melphalan exposure was reduced in the LR5 compared to the drug sensitive cell 8226 using single cell comet assay. Using siRNA to knock down FANCL or FANCF in melphalan-resistant cell line LR5 reversed the drug resistance. Conversely, overexpression of FANCL or FANCF in the 8226/S drug sensitive cell line enhanced cell survival. These data show that enhanced DNA repair via Fanconi anemia/BRCA pathway is involved in melphalan-resistant myeloma cells.
ChemInform Abstract: Preparation of 6‐, 7‐, and 8‐Membered Sultams by Friedel‐Crafts Cyclization ω‐Phenylalkanesulfamoyl Chlorides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pharmaceutical Water: System Design, Operation, and Validation, Second Edition (2010)

A major new work on all aspects of water, the most used raw material ingredient in the pharmaceutical and biotechnology industries-used as an excipient in pharmaceutical formulations, as a cleaning agent, and as a separately packaged product diluent.Drawing on the author's extensive field experience with more than 400 pharmaceutical and related wat
rhBMP-12 Accelerates Healing of Rotator Cuff Repairs in a Sheep Model (2008)

Delivery of rhBMP-12 in several sponge carriers has the potential to accelerate healing of rotator cuff repairs. Accelerated repair may allow shorter rehabilitation and an earlier return to occupational and recreational activities.
Managing Ungulates to Protect Trees (2003)

ig game species, such as elk and deer, inflict the most widespread form of damage to forest resources. Elk may trample or pull seedlings without well-established root systems out of the ground. Browsing elk often splinter woody stems. During the spring, the stems may be stripped of bark below where they break the stem. Deer damage inflicted on seedlings is similar to elk damage. Woody stems are often splintered and the bark is stripped from twigs. New buds are generally clipped back to the previous year’s growth. Deer do not pull seedlings as frequently as elk and their damage rarely occurs above six feet.
The Complete Plastid Genome Sequence of Iris gatesii (Section Oncocyclus), a Bearded Species from Southeastern Turkey (2014)

Iris gatesii is a rare bearded species in subgenus Iris section Oncocyclus that occurs in steppe communities of southeastern Turkey. This species is not commonly cultivated, but related species in section Iris are economically important horticultural plants. The complete plastid genome is reported for I. gatesii based on data generated using the Illumina HiSeq platform and is compared to genomes of 16 species selected from across the monocotyledons. This Iris genome is the only known plastid genome available for order Asparagales that is not from Orchidaceae. The I. gatesii plastid genome, unlike orchid genomes, has little gene loss and rearrangement and is likely to be similar to other genomes from Asparagales. The plastid genome of I. gatesii demonstrates expansion of the inverted repeat, loss of 95% of the rps19–rpl22 intergenic spacer, the presence of introns in several protein-coding regions, and alternate start codons. Potentially variable regions are identified for further study.
Evidence for a heritable predisposition to Chronic Fatigue Syndrome (2011)

These analyses provide strong support for a heritable contribution to predisposition to Chronic Fatigue Syndrome. A population of high-risk CFS pedigrees has been identified, the study of which may provide additional understanding.