gebhart/patrepeval huggingface dataset:
Structural Variants of Methyl Eugenol and Their Attractiveness to the Oriental Fruit Fly (Diptera: Tephritidae) (1994)

Journal Article Structural Variants of Methyl Eugenol and Their Attractiveness to the Oriental Fruit Fly (Diptera: Tephritidae) Get access A. B. DeMilo, A. B. DeMilo Search for other works by this author on: Oxford Academic PubMed Google Scholar R. T. Cunningham, R. T. Cunningham Search for other works by this author on: Oxford Academic PubMed Google Scholar T. P. McGovern T. P. McGovern Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 87, Issue 4, 1 August 1994, Pages 957–964, https://doi.org/10.1093/jee/87.4.957 Published: 01 August 1994 Article history Received: 25 May 1993 Accepted: 07 February 1994 Published: 01 August 1994
Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization (2010)

Altogether, our data demonstrate that regulation of proangiogenic Ly6C(hi) monocytes systemic levels by CCL2/CCR2 controls post-ischaemic vessel growth, whereas Ly6C(lo) monocytes have no major role in this setting.
IC‐P‐173: INDIVIDUAL‐BASED NETWORK ANALYSIS: A NOVEL APPROACH TO INVESTIGATE THE PATHOLOGICAL SPREAD OF PHF TAU USING GRAPH THEORY IN CLINICAL AND PRECLINICAL STAGES OF ALZHEIMER'S DISEASE (2019)

The spread of paired helical filaments(PHF) tau in the brain is currently under investigation. Different groups suggest tau could be either propagating from a seed or an imbalance in local production and clearance that leads to increased deposition. Studies have used resting state fMRI with tau PET to understand the spread of tau in humans. In this study, we introduce a new subject-based measure of tau PET connectivity that describes the spread of tau using only Flortaucipir(FTP)PET images. Here we demonstrate how FTP PET network measurements of tau spread differentiates probable Alzheimer's dementia(pAD), mild cognitive impairment(MCI), and cognitively unimpaired(CU) study participants from the Alzheimer's Disease NeuroImaging Initiative(ADNI), and suggest its promise to detect differences in network measures in CU persons at genetic risk for AD. We determined a FTP network for each subject using a method from graph theory. From the undirected weighted graph created from the inter-regional distances, the global and local (efficiency, network strength) measurements of spread of tau in the network were calculated. Next, we compared our measurements to SUVR in common regions such as prespecified ROIs (entorhinal, parahippocampal, inferior temporal, precuneus) as well as mean cortical region from Mayo and partial volume corrected(PVC)SUVR BraakI-II, BraakIII-IV, and BraakV-VI from Berkeley in their ability to distinguish 15 pAD, 63 MCI, and 81 CU research participants from one another. Finally, we compared these novel and established measurements in their ability to distinguish in CU 49 APOE4 carriers from 24 non-carriers. Like several of the established ROI flortaucipir PET measurements, each of the global and several of the local flortaucipir connectivity measurements were significantly different in the three subject groups(pAD>MCI>CU,p<E-5). As expected, we found higher FTP efficiency(spread) for AD patients. In contrast to all but one of the ROI methods(PVC_Braak_V-VI_SUVR,p=0.03), flortaucipir global efficiency, strength measurements were significantly different in the CU APOE4 carrier and non-carrier groups (p=0.004,0.005). This study introduces previously untapped information from FTP PET. It suggests that these measurements may offer greater power than conventional ROI measurements in the preclinical stages. Additional studies are needed to clarify the value of FTP connectivity measurements in the detection and tracking of AD.
tert‐Butyldiphenylsilylethyl (“TBDPSE”): A Practical Protecting Group for Phenols. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effects of changes in adipocyte hormones and visceral adipose tissue and the reduction of obesity-related comorbidities after laparoscopic sleeve gastrectomy in Japanese patients with severe obesity (2014)

The aim of this study was to evaluate the relative contribution of serum adipokines and adipokines from the patient's omentum-derived adipocytes (PODAs) and visceral adipose tissue (VAT) of Japanese patients with severe obesity. Secondarily, we analyzed patients' metabolic changes after laparoscopic sleeve gastrectomy (LSG). Twenty-three LSG patients and 23 non-obese patients undergoing elective abdominal surgery were enrolled. The levels of adipokines in the serum and the PODAs were measured. The clinical and metabolic data were evaluated at 6 months after LSG. The mean serum leptin levels and the mean serum plasminogen activator inhibitor type-1 (PAI-1) levels were significantly greater (p < 0.001) and the mean adiponectin levels were significantly lower in the LSG group (p = 0.006). In the measurements of the PODAs, the mean leptin levels (p < 0.001) were significantly greater and the mean adiponectin levels (p < 0.001) were significantly lower in the LSG group. The mean BMI (-12 kg/m², p < 0.001) and mean VAT (-135.5 cm², p = 0.001) were significantly decreased after LSG. In nine patients with type 2 diabetes mellitus, the reduction in VAT correlated with the change in high-sensitivity C-reactive protein (p = 0.006) and the homeostasis model of assessment of insulin resistance (p = 0.001). After 6 months, LSG markedly improved most obesity-related comorbidities. Our results suggest that LSG may contribute to VAT reduction, improved adipocyte hormone levels, and changes in gut physiology and endocrinology.
Simulation-based prediction of multimode fiber bandwidth for 10 Gb/s systems (2003)

The recent wide-spread deployment of gigabit, multimode, optical data links has led to the need for better design methodologies to both lower cost and improve performance. One of the most critical performance predictors for these systems is the bandwidth of the multimode fiber used in the link. We have demonstrated, through an integrated device/system simulation environment, that an empirical differential-mode delay-based method for predicting modal bandwidth can be accurate to within a few percent of the more rigorous index-based method.
Randomized Dose‐Ranging Study of the Safety and Efficacy of WR 238605 (Tafenoquine) in the Prevention of Relapse ofPlasmodium vivaxMalaria in Thailand (1999)

WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were randomly assigned to 1 of 4 treatment regimens: 3 groups received a blood schizonticidal dose of chloroquine followed by WR 238605: group A (n=15) received 300 mg daily for 7 days; group B (n=11), 500 mg daily for 3 days, repeated 1 week after the initial dose; group C (n=9), 1 dose of 500 mg. A fourth group (D; n=9) received chloroquine only. Among patients who completed 2-6 months of follow-up (n=23), there was 1 relapse in group B (day 120) and 1 in group C (day 112). Among patients treated with chloroquine only, there were 4 relapses (days 40, 43, 49, and 84). WR 238605 was safe, well tolerated, and effective in preventing P. vivax relapse.
Multimodal Trust Formation with Uninformed Cognitive Maps (UnCM) (Extended Abstract) (2012)

This work describes a cognitive heuristic allowing agents to assess trust and delegations merging heterogenous information sources. The model is realized through Uninformed Cognitive Maps, based on the combination of: (i) categorization abilities (ii) history of personal experiences (iii) context awareness.
Heat Shock Protein-60 and Risk for Cardiovascular Disease (2011)

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.
Evaluation of the focal distance of a lens by Talbot interferometry (1988)

A simple and precise technique, based on Talbot interferometry, of measuring the focal distance of a simple lens or a compound lens system is described. To establish the foundations of the technique, properties of selfimages in free space and of their images, when formed by a lens, are first examined and experimentally demonstrated.
Phase transitions of iron sulphides formed by steel microbial corrosion (2013)

In this study, we investigated the iron sulphides phase transitions resulting from steel corrosion under sulphate-reducing-bacteria conditions. Experiments were conducted at 30 °C from 7 to 240 aging days. Culture batch experiments were conducted with steel coupons, clay and groundwater amended with lactate to simulate steel degradation under anaerobic conditions. Solutions were monitored by inductively-coupled plasma mass spectrometry and ionic chromatography. The corrosion products were investigated by scanning electron microscopy/energy dispersive X-ray spectroscopy, X-ray diffraction and by confocal micro-Raman spectrometry. Microbial activity was evidenced by a drop in sulphate concentration and production of sulphide. In the early stages of corrosion (7 days) poorly crystallised iron sulphide (FeS) was identified, followed by the formation of mackinawite (FeS1−x) and after 30 days, mackinawite evolved into pyrrhotite (FeS1+x) and ultimately to the more stable pyrite (FeS2). The same mineralogical sequence was identified in similar abiotic experiments in the presence of increasing sulphide concentration. The evolution of Raman vibrational spectra was quantitatively examined for the first time and the protective role of the pyrrhotite and pyrite layers with increasing time was discussed.
High-Throughput Prediction of Blood−Brain Partitioning:  A Thermodynamic Approach (2000)

A high-throughput in silico screening tool for potentially CNS active compounds was developed on the basis of the correlation of solvation free energies and blood−brain partitioning (log(cbrain/cblood) = log BB) data available from experimental sources. Utilizing a thermodynamic approach, solvation free energies were calculated by the fast and efficient generalized Born/surface area continuum solvation model, which enabled us to evaluate more than 10 compounds/min. Our training set involved a structurally diverse set of 55 compounds and yielded a function of log BB = 0.035Gsolv + 0.2592 (r = 0.85, standard error 0.37). Calculation of solvation free energies for 8700 CNS active compounds (CIPSLINE database) revealed that Gsolv is higher than −50 kJ/mol for the 96% of these compounds which can be used as suitable criteria for the identification of compounds preferable for CNS penetration.
Evaluating Tissue Tests to Improve Nitrogen Management in Furrow‐Irrigated Mid‐South Corn Production (2018)

An ear‐leaf N of 30 g kg −1 differentiated between N‐adequate and N‐deficient corn plants at the R1 growth stage. The optimal corn stalk nitrate concentration ranged from 170 to 1000 mg nitrate N kg −1 at maturity. Nitrogen availability was excessive when stalk nitrate concentration values were &gt;1000 mg nitrate N kg −1 . The N rate needed for 95% relative grain yield was consistently near the N rate where nitrate accumulated in the stalk. The corn stalk nitrate test (CSNT) and ear‐leaf N concentration (ELNC) are used to determine the adequacy of corn ( Zea mays L.) N management programs and is used most extensively in the Midwest and northeastern United States. Information on the utility of both the CSNT and ELNC for irrigated corn produced in the mid‐South is lacking. Twenty‐four N rate trials were conducted in Arkansas between 2013 and 2016 to evaluate the utility of the ELNC and CSNT in a furrow‐irrigated corn production system. An ELNC of 30 g kg −1 has been determined to differentiate between N‐adequate and N‐deficient corn plants at the R1 growth stage. The optimal CSNT concentration ranged from 170 to 1000 mg nitrate N kg −1 at maturity, indicating that adequate N was available to the corn crop to produce near‐maximum grain yield. The N rate needed to achieve 95% relative grain yield (RGY) was consistently identified near the N rate where nitrate N began to accumulate in the corn stalk. A CSNT values of &lt;170 mg nitrate N kg −1 was found to represent the low category, suggesting that N was limiting corn grain yield, whereas N availability was found to exceed the amount needed to maximize grain yield when CSNT values were &gt;1000 mg nitrate N kg −1 . The ELNC and CSNT can be used to adequately determine the N status of corn produced within a furrow‐irrigated mid‐South corn production system.
Seedless Calimyrna figs: Produced without caprifigs by spraying with growth regulators (1948)

Seedless Calimyrna figs may be produced without the use of male or caprifigs, by spraying the trees with a solution of indolebutyric acid at caprification—pollination—time.
Dimensional reduction in supersymmetric field theories (2002)

A class of quantum field theories invariant with respect to the action of an odd vector field Q on a source supermanifold Σ is considered. We suppose that Q satisfies the conditions of one of the localization theorems (Szabo R 1996 Equivariant localization of path integrals Preprint hep-th/9608068). The Q-invariant sector of a field theory from the above class is then shown to be equivalent to the quantum field theory defined on the zero locus of the vector field Q.
Retention of Free Liquids in Landfills Undergoing Vertical Expansion (1999)

This paper presents the results of an evaluation of the potential release of liquids stored within a waste mass undergoing compression due to a landfill vertical expansion. The mechanism of free liquid generation is initially evaluated and data interpretation methods are developed to estimate the maximum allowable waste thickness that a landfill could reach without releasing liquids stored within the waste. The proposed conceptual framework of free liquid generation is used to evaluate the environmental implications of the vertical expansion of an unlined case history landfill located in southern California. The moisture content of waste in southern California landfills is generally below field capacity. However, if the waste is compressed, its available moisture-holding capacity will decrease and its moisture content may eventually reach field capacity. Additional compression beyond this point will squeeze liquid from the waste. Laboratory testing and field characterization programs were undertaken to evaluate the field capacity, the in-situ moisture distribution, and the unit weight profiles of the waste in the case history landfill. These experimental data were used to evaluate the ability of the landfill to continue to retain moisture after continued waste placement. The evaluation indicated that the moisture content of the waste will not reach its field capacity for the proposed final grading of the case history landfill and, therefore, that the liquids should remain within the waste mass after the vertical expansion.
Sensitivity to geometric shape regularity in humans and baboons: A putative signature of human singularity (2021)

Among primates, humans are special in their ability to create and manipulate highly elaborate structures of language, mathematics or music. We show that this sensitivity is present in a much simpler domain: the visual perception of geometric shapes. We asked human subjects to detect an intruder shape among six quadrilaterals. Although the intruder was defined by an identical amount of displacement of a single vertex, the results revealed a geometric regularity effect: detection was considerably easier with most regular shapes. This effect was replicated in several tasks and in both uneducated adults and preschoolers. Baboons, however, showed no such geometric regularity effect even after extensive training. Baboon behavior was captured by convolutional neural networks (CNNs) but a symbolic model was needed to fit human behavior. Our results indicate that the human propensity for symbolic abstraction permeates even elementary shape perception and they suggest a new putative signature of human singularity.
A dual polarized UWB slot antenna with kite shaped slot for high isolation (2015)

In this paper, the design of a two port antenna for ultra wideband applications is presented. The radiating element in the antenna is an L-shaped slot which is excited using two microstrip feed lines for generating the orthogonal polarizations. The slot and the feed lines have stepped profiles for achieving wideband impedance matching. The decoupling between the ports is provided by means of three different structures. First, a slant metallic strip is attached at a corner inside the L-shape slot, next, a trident shaped slot is etched below the L-shape slot near its corner and finally, a kite shaped slot is placed in the center. The impedance bandwidth achieved with the antenna is from 3 GHz to 11.6 GHz while the isolation is better than 20 dB from 3.8 GHz onwards. The dual polarized nature of the antenna is shown from the aperture electric field distribution and the radiation patterns. The peak gain of the antenna varies from 4 to 6 dBi over the band. The antenna is expected to be useful for dual polarization applications in radar, imaging and high speed wireless communication.
Ether‐ and Thioether‐Linked Naphthalene‐Based Liquid‐Crystal Dimers: Influence of Chalcogen Linkage and Mesogenic‐Arm Symmetry on the Incidence and Stability of the Twist–Bend Nematic Phase (2019)

The twist-bend nematic (N<sub>TB</sub> ) phase with a heliconical nanostructure of the local director generating symmetry breaking by achiral bent-shaped molecules is a hot topic of current liquid-crystal science. As opposed to the most common methylene-linked dimers, this study demonstrates chalcogen ether- and/or thioether-linked 6-(4-cyanophenyl)-2-naphthyl-based liquid-crystal dimers with symmetric and asymmetric π-conjugated mesogenic-arm structures that exhibit the N<sub>TB</sub> phase. Although the symmetric bis(ether)-linked dimer exhibits only the conventional nematic (N) phase, the asymmetric bis(ether)-linked dimer can form the N<sub>TB</sub> phase. All thioether-linked dimers form the N<sub>TB</sub> phase, wherein the dimers with asymmetric arms vitrify in the N<sub>TB</sub> phase on cooling to room temperature. The phase transitions are discussed in terms of the chalcogen linkage combination, mesogenic-arm symmetry, and spacer length. It is revealed that thioether-linked dimers based on asymmetric π-conjugated mesogenic arms with terminal cyano groups are highly beneficial for the realization of materials that form a wide range of N<sub>TB</sub> phases and glassy N<sub>TB</sub> states at room temperature.
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer (2019)

As a key glycolysis enzyme, the significance of pyruvate dehydrogenase kinase 1 (PDK1) in the development of colorectal cancer (CRC) remains unknown. This study revealed that the prognosis of CRC patients with high levels of PDK1 was poor, and PDK1 knockdown significantly reduced liver metastasis of CRC in both nude mice and immune competent BALB/C mice. When combined with cryptotanshinone (CPT), an inhibitor of STAT3-p-Y705, the liver metastasis was further inhibited. PDK1 knockdown obviously increased reactive oxygen species level in anoikis conditions and subsequently resulted in an elevated anoikis, but the combination of PDK1 knockdown and CPT showed a reduced effect on anoikis. Based on this discrepancy, the adherence ability of CRC cells to matrix protein fibronectin was further detected. It showed that PDK1 knockdown significantly decreased the adherence of CRC cells to fibronectin when combined with CPT. These results suggest that inhibition of PDK1 can decrease the surviving CRC cells in blood circulation via up-regulation of anoikis, and inhibition of STAT3-p-Y705 can prevent it to settle down on the liver premetastatic niche, which ultimately reduces liver metastasis.
[Hepatic steatosis in obesity in children]. (1991)

The fatty liver infiltrations of the children are not uncommon and are often seen in particular diseases, mainly related to intoxication or metabolic diseases. The authors reported a case of heterogeneous fatty liver infiltration due to obesity with a good evolution after a hypocaloric diet.
Dense OPC for 65nm and below (2005)

In this paper, we evaluate the use of dense pixel-based simulation for OPC corrections at 65nm and below. Dense OPC can be performed in one of two "domains": (1) pixel domain or (2) edge domain. We describe the difference between these two domains and describe techniques which are suitable for those domains. The use of fast contour based OPC verification is critical to determine which OPC techniques perform best.
Recombinant Antibodies Against Haptenic Mycotoxins (1995)

Recent developments in the molecular biology of antibody production have provoked much excitement among researchers interested in the generation of recombinant antibodies for immunodiagnostics. The speed of probe generation and the potential for manipulation of binding site properties would compare favourably with the difficulties (and cost) of monoclonal antibody production against haptens and other problematic targets. Unfortunately, translation of molecular biology methodology from other areas of research, in spite of the availability of kits, has not proved straightforward. This paper outlines some of the problems that have been encountered and some solutions employed in the production of short-chain Fvs to haptens. These targets present interesting problems to the immunochemist, particularly in situations where antibodies of broad specificity are sought.
Oriented tensor reconstruction: tracing neural pathways from diffusion tensor MRI (2002)

In this paper we develop a new technique for tracing anatomical fibers from 3D tensor fields. The technique extracts salient tensor features using a local regularization technique that allows the algorithm to cross noisy regions and bridge gaps in the data. We applied the method to human brain DT-MRI data and recovered identifiable anatomical structures that correspond to the white matter brain-fiber pathways. The images in this paper are derived from a dataset having 121/spl times/88/spl times/60 resolution. We were able to recover fibers with less than the voxel size resolution by applying the regularization technique, i.e., using a priori assumptions about fiber smoothness. The regularization procedure is done through a moving least squares filter directly incorporated in the tracing algorithm.