gebhart/patrepeval huggingface dataset:
The similarity join database operator (2010)

Similarity joins have been studied as key operations in multiple application domains, e.g., record linkage, data cleaning, multimedia and video applications, and phenomena detection on sensor networks. Multiple similarity join algorithms and implementation techniques have been proposed. They range from out-of-database approaches for only in-memory and external memory data to techniques that make use of standard database operators to answer similarity joins. Unfortunately, there has not been much study on the role and implementation of similarity joins as database physical operators. In this paper, we focus on the study of similarity joins as first-class database operators. We present the definition of several similarity join operators and study the way they interact among themselves, with other standard database operators, and with other previously proposed similarity-aware operators. In particular, we present multiple transformation rules that enable similarity query optimization through the generation of equivalent similarity query execution plans. We then describe an efficient implementation of two similarity join operators, ¿-Join and Join-Around, as core DBMS operators. The performance evaluation of the implemented operators in PostgreSQL shows that they have good execution time and scalability properties. The execution time of Join-Around is less than 5% of the one of the equivalent query that uses only regular operators while ¿-Join's execution time is 20 to 90% of the one of its equivalent regular operators based query for the useful case of small ¿ (0.01% to 10% of the domain range). We also show experimentally that the proposed transformation rules can generate plans with execution times that are only 10% to 70% of the ones of the initial query plans.
Central Function for JAM-a in Multiple Myeloma Patients with Extramedullary Disease (2018)

Abstract During the last years, multiple myeloma (MM) has been recognized to present in some patients with extra-medullary disease (EMD) manifestation with different pathophysiological and clinical characteristics. Recently, we reported junctional adhesion molecule-A (JAM-A) as a novel target and a clinical biomarker in MM [Solimando et al. Leukemia 32(3):736-743, 2018]. Here, we hypothesized that alterations in the adhesion molecules, particularly JAM-A expression, on MM plasma cells (MM-PCs) may play a pivotal role in high-risk EMD patients. Therefore, we evaluated JAM-A expression in 60 MM patient bone marrow (BM) aspirates and biopsies at different disease stages with flow cytometry and immunohistochemistry. We compared these results with RNA-Seq data from 647 newly diagnosed MM (NDMM) patients collected in the MMRF (MM Research Foundation) CoMMpass study. Using bioinformatics, we investigated JAM-A related pathways with hierarchical cluster analysis. Subsequently, we functionally tested these JAM-A related pathways regarding epithelial mesenchymal transition, invasion and MM dissemination in vitro. The median OS differed significantly in subjects with elevated membrane JAM-A expression levels, dividing the patients in EMD JAM-Ahighgroup with a median OS of 84.1 months, whereas median OS in JAM-Alowpatients was not reached, irrespective from the EMD status (log-rank=4.19, P=0.04). Immunohistochemistry analysis of BM biopsies confirmed these findings. RNA-Seq analysis corroborated the prognostic impact of JAM-A (log-rank= 3.8, P= 0.051).High-risk myeloma patients with EMD and JAM-A expression displayed a unique gene-expression signature. Additionally, we constructed a novel expression cluster subgroup MM model, revealing complex molecular disease patterns and associations between clinical traits and expression markers. MM patients clustering according to JAM-A expression levels and EMD manifestation revealed a clear link to the epithelial-mesenchymal-transition and focal adhesion pathways. Notably, functional knockdown of JAM-A in vitro not only reduced cell viability, but also diminished MM adhesion molecules and CD138 surface expression. Furthermore, mTOR/PI3K in vitro inhibition with BEZ235 significantly down regulated surface expression in JAM-Ahigh MM cell lines. Interestingly, when we inhibited mTOR/PI3K in JAM-AlowMM cells, we observed JAM-A induction. In the present study we shed more light on the EMD pathophysiology. Conclusively, our results support that JAM-A can serve as promising prognostic marker for high risk EMD MM patients. Our data provide a biological rationale for a JAM-A guided decision-making process to better combine molecular and immunochemo-therapy modalities in the EMD MM patient subset. Disclosures No relevant conflicts of interest to declare.
Immobilization of Lactobacillus plantarum NCIMB 8826 ameliorates Citrobacter rodentium induced lesions and enhances the gut inflammatory response in C57BL/6 weanling mice (2022)

Abstract Infectious diarrhea is a major cause of infant mortality in most developing countries. In this research, we evaluated the potential of immobilized Lactobacillus plantarum NCIMB 8826 on weanimix infant cereal and its effectiveness in reducing the severity of Citrobacter rodentium -induced diarrhea in weanling mice. Thirty-six C57BL/6 weanling mice were placed into four groups ( n = 9 each; negative, positive, prevention and cure). Mice received either L. plantarum (10 9 CFU/g) immobilized on weanimix infant cereal 3 days before C. rodentium (10 9 CFU/ ml) infection (Prevention) or 3 days after C. rodentium infection (Cure). A positive control group was infected with C. rodentium only, while a negative control group received neither L. plantarum nor C. rodentium . Positive control mice showed colonic mucosal and submucosal inflammation, erosion, and mucosal epithelia hyperplasia with the C. rodentium infection. Mice in the prevention and cure groups had less severe histologic alterations in the colon. Some beneficial effect of L. plantarum was observed in cecal short-chain fatty acid concentrations, which stimulates water and electrolytes absorption to reduce diarrhea. Our findings demonstrated that L. plantarum NCIMB 8826 could be immobilized on weanimix infant cereal to help reduce diarrhea during weaning. Graphical Abstract
Analysis of Price of Anarchy in Traffic Networks With Heterogeneous Price-Sensitivity Populations (2015)

In this paper, we investigate how the scaled marginal-cost road pricing improves the price of anarchy (POA) in a traffic network with one origin-destination pair, where each edge in the network is associated with a latency function. The POA is defined as the worst possible ratio between the total latency of Nash flow and that of the socially optimal flow. All players in the noncooperative congestion game are divided into groups based on their price sensitivities. First, we consider the case where all players are partitioned into two groups in a network with two routes. In this case, it is shown that the total latency of the Nash flow can always reach the total latency of the socially optimal flow if the designed road price is charged on each link. We then analyze the POA for general case. For a distribution of price sensitivities satisfying certain conditions, a road pricing scheme is designed such that the unique Nash flow can achieve the social optimal flow, i.e., $\text {POA}=1$ . An algorithm is proposed to find the price scheme that optimizes the POA for any distribution of price sensitivities and any traffic network with one origin-destination pair. Finally, the results are applied to a traffic routing problem.
Figure S6AB from Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer (2023)

&lt;p&gt;Supplementary figure&lt;/p&gt;
Regulation of Mammalian Target of Rapamycin Activity in PTEN-Inactive Prostate Cancer Cells by IκB Kinase α (2007)

The mammalian target of rapamycin (mTOR) is a mediator of cell growth, survival, and energy metabolism at least partly through its ability to regulate mRNA translation. mTOR is activated downstream of growth factors, insulin, and Akt-dependent signaling associated with oncoprotein expression or loss of the tumor-suppressor PTEN. In this regard, mTOR activity is associated with cancer cell growth and survival. Here, we have explored an involvement of the I kappa B kinase (IKK) pathway, associated with nuclear factor-kappaB activation, in controlling mTOR activity. The experiments show that IKK alpha controls mTOR kinase activity in Akt-active, PTEN-null prostate cancer cells, with less involvement by IKK beta. In these cells, IKK alpha associates with mTOR, as part of the TORC1 complex, in an Akt-dependent manner. Additionally, IKKalpha is required for efficient induction of mTOR activity downstream of constitutively active Akt expression. The results indicate a novel role for IKK alpha in controlling mTOR function in cancer cells with constitutive Akt activity.
A daily regimen of a ceramide‐dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial (2021)

The dysfunctional skin barrier in eczema patients may be attributed to decreased levels of ceramides in the stratum corneum. The aim of this study was to determine whether a two-part system consisting of a ceramide-dominant physiological lipid-based moisturizing cream and cleanser could ameliorate the signs and symptoms of moderate eczema in adults over 28 days compared to placebo. Assessments were conducted at baseline and every 7 days thereafter. Eczema area severity index score decreased significantly across all time points in both groups compared to baseline (P < .0001), however, this decrease was not significant between groups at day 28 (P = .7804). In contrast, transepidermal water loss and skin hydration significantly improved over time in the active group, while it either stayed the same or worsened in the placebo group (P = .0342 and P < .0001, respectively). There was no difference in the use of mometasone furoate as rescue medication over time between groups (P = .1579). Dermatology life quality index scores improved significantly in both groups (P < .0001), with no difference between groups (P = .5256). However, patient satisfaction was greater in the active compared to the placebo group for several parameters including relief of itch, dry skin, skin softness and smoothness (all P < .05). No patients withdrew from the study due to adverse events (AEs) and there were no serious AEs. The ceramide-dominant moisturizing cream and cleanser safely restores skin permeability and improves the signs and symptoms of eczema in adults.
Contact dermatitis to bufexamac. (1982)

Description of 3 cases of contact dermatitis to bufexamac cream, which is largely used in dermatology as a nonsteroid anti-inflammatory agent. Moreover, since this substance shows a distinct fluorescent spectra, we must not forget that a photodynamic phenomenon may play a part in the skin sensitization.
AN e+e- COLLIDER IN THE VLHC TUNNEL (2001)

We describe the design of an e + e - collider that could be installed in the tunnels of the VLHC to run before that machine. We consider the arguments required to maximize the luminosity and indicate what effects would limit the machine performance. We also describe the primary technical issues involved with the construction of the components and consider how costs could be minimized. where ξy, P , ρ, and β y* are the beam-beam tune shift, radiated synchrotron power for two beams, bending radius, and the beta function at the interaction point. While the beam-beam tune shift, ξy, is in the range of 0.03 for most lepton colliders, it was found at LEP that very stable operation was obtained at high energies with values of 0.08-0.09. These values were, however, limited by the bunch current at injection. During the last run of LEP, the goal was to reach the highest energy possible, and the beam-beam limit was not reached. Since ξ y, scales with the damping decrement, we expect values of 0.14 - 0.17 at 185 GeV with two IR's. With a single IR, the beam-beam parameter could be higher, giving a luminosity close to 10 34 cm -1 s -2 . We have assumed that the radiated power, P, for both beams will be 100 MW. In addition to its effect on the luminosity, this number determines the size of the cooling system, the size of the rf system required to replace this
Supplementary Figure S4 from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer (2023)

&lt;p&gt;Supplementary Figure S4: Structure, binding affinity and in vitro potency of FB inhibitor.&lt;/p&gt;
Helicoverpa armigera resistance to insecticides in Pakistan (1998)

Helicoverpa armigera resistance to insecticides in Pakistan , Helicoverpa armigera resistance to insecticides in Pakistan , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Nonhomogeneous Risk Rank Analysis Method for Security Network System (2019)

Security measures for a computer network system can be enhanced with better understanding the vulnerabilities and their behavior over the time. It is observed that the effects of vulnerabilities vary with the time over their life cycle. In the present study, we have presented a new methodology to assess the magnitude of the risk of a vulnerability as a “Risk Rank”. To derive this new methodology well known Markovian approach with a transition probability matrix is used including relevant risk factors for discovered and recorded vulnerabilities. However, in addition to observing the risk factor for each vulnerability individually we have introduced the concept of ranking vulnerabilities at a particular time taking a similar approach to Google Page Rank Algorithm. New methodology is exemplified using a simple model of computer network with three recorded vulnerabilities with their CVSS scores.
Energy-Efficient and Metastability-Immune Resilient Circuits for Dynamic Variation Tolerance (2009)

A 65 nm resilient circuit test-chip is implemented with timing-error detection and recovery circuits to eliminate the clock frequency guardband from dynamic supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> ) and temperature variations as well as to exploit path-activation probabilities for maximizing throughput. Two error-detection sequential (EDS) circuits are introduced to preserve the timing-error detection capability of previous EDS designs while lowering clock energy and removing datapath metastability. One EDS circuit is a dynamic transition detector with a time-borrowing datapath latch (TDTB). The other EDS circuit is a double-sampling static design with a time-borrowing datapath latch (DSTB). In comparison to previous EDS designs, TDTB and DSTB redirect the highly complex metastability problem from both the datapath and error path to only the error path, enabling a drastic simplification in managing metastability. From a survey of various EDS circuit options, TDTB represents the lowest clock energy EDS circuit known; DSTB represents the lowest clock energy static-EDS circuit with SER protection known. Error-recovery circuits are introduced to replay failing instructions at lower clock frequency to guarantee correct functionality. Relative to conventional circuits, test-chip measurements demonstrate that resilient circuits enable either 25%-32% throughput gain at equal V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> or at least 17% V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> reduction at equal throughput, corresponding to 31%-37% total power reduction.
Composition and volatility of SOA formed from oxidation of real tree emissions compared to single VOC-systems (2019)

Abstract. Secondary organic aerosol (SOA) is an important constituent of the atmosphere where SOA particles are formed chiefly by the condensation or reactive uptake of oxidation products of volatile organic compounds (VOC). The mass yield in SOA particle formation, as well as the chemical composition and volatility of the particles are determined by the identity of the VOC precursor(s) and the oxidation conditions they experience. In this study, we used an oxidation flow reactor to generate biogenic SOA from the oxidation of Scots pine emissions. Mass yields, chemical composition, and volatility of the SOA particles were characterized and compared with SOA particles formed from oxidation of α-pinene and of a mixture of acyclic/monocyclic sesquiterpenes (farnesenes and bisabolenes), which are significant components of the Scots pine emissions. SOA mass yields for Scots pine emissions dominated by farnesenes were lower than for α-pinene, but higher than for the artificial mixture of farnesenes and bisabolenes. The reduction in the SOA yield in the farnesenes and bisabolenes dominated mixtures is due to C=C bond scission in these acyclic/monocyclic sesquiterpenes during ozonolysis leading to smaller and generally more volatile products. SOA particles from the oxidation of Scots pine emission had similar or lower volatility than SOA particles formed from either of single precursor. Applying physical stress to the Scots pine plants increased monoterpene emissions, which further decreased SOA particle volatility and increased SOA mass yield. Our results highlight the need to account for the chemical complexity and structure of real-world biogenic VOC emissions and stress-induced changes to plant emissions when modelling SOA production and properties in the atmosphere. These results emphasize that simple increase or decrease of relative monoterpene and sesquiterpene emissions should not be used as indicator of SOA particle volatility.
Effect of microalloying on the toughness of metallic glasses (2012)

The effect of microalloying on the toughness of Cu-Ti-based metallic glasses is explored. Minor additions of Si and Sn in glass former Cu47Ti34Zr11Ni8 known to improve glass-forming ability are found here to sharply decrease toughness. The drop in toughness is associated with a small but meaningful increase in shear modulus, glass-transition temperature, yield strength, and a decrease in Poisson's ratio, implying a negative correlation between toughness and shear flow barrier. The strong influence of minor additions on the glass properties could be a useful tool for simultaneously tuning both the glass-forming ability and toughness of metallic glasses.
Ring-shaped caliper for better anterior capsulorhexis sizing and centration (2006)

We describe a new type of caliper to optimize the size, shape, and centration of the capsulorhexis during intraocular lens (IOL) surgery. This flexible, ring-shaped tool is positioned on the anterior capsule surface, where it is kept in place by an ophthalmic viscosurgical device. When in place, the caliper provides an ideal guide for the surgeon to follow and facilitates optimal capsulorhexis shape and centration.
Prognostically orientated multimodality treatment including surgery for selected patients of small-cell lung cancer patients stages IB to IIIB: Long-term results of a phase II trial (1999)

Following mediastinoscopy, a prognostically orientated multimodality approach was chosen in selected small-cell lung cancer (SCLC) patients with hyperfractionated accelerated chemoradiotherapy (Hf-RTx) and definitive surgery (S). Stage IB/IIA patients had four cycles of cisplatin/etoposide (PE) and surgery. Stage IIB/IIIA patients had three cycles PE followed by one cycle concurrent chemoradiation including Hf-RTx and surgery. Most stage IIIB patients were not planned for surgery and had CTx followed by sequential RTx or one cycle concurrent CTx/RTx. Of 46 consecutive patients (stage IB six, IIA two, IIB/IIIA 22, IIIB 16) 43 (94%) showed an objective response. Twenty-three of patients (72%) planned for inclusion of S were completely resected (R0) (IB 6/6, IIA 2/2, IIB/IIIA 13/22, IIIB 2/2). Overall toxicity was acceptable--one patient died of septicaemia, no perioperative deaths occurred. Median follow-up of patients alive (n = 21) is 52 months (30+ - 75+). Median survival and 5-year survival rate of all patients are 36 months and 46%, in R0 patients 68 months and 63% (R0-IIB/IIIA/IIIB: not yet reached and 67%). This multimodality treatment including surgery proved highly effective with 100% local control and remarkable long-term survival after complete resection, even in locally advanced SCLC stages IIB/IIIA patients.
Analysis of multicomponent mass spectra applying Bayesian probability theory (2001)

In this paper we develop a method for the decomposition of mass spectra of gas mixtures, together with the relevant calibration measurements. The method is based on Bayesian probability theory. Given a set of spectra, the algorithm returns the relative concentrations and the associated margin of confidence for each component of the mixture. In addition to the concentrations, such a data set enables the derivation of improved values of the cracking coefficients of all contributing species, even for those components for which the set does not contain a calibration measurement. This latter feature also allows one to analyze mixtures that contain radicals in addition to stable molecules. As an example, we analyze and discuss the mass spectra obtained from the pyrolysis of azomethane, which contain the radical CH3 apart from nitrogen and C1- and C2-hydrocarbons.
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV‐Cripto‐1 transgenic mice (2004)

Epithelial-mesenchymal transition (EMT) facilitates migration and invasion of epithelial tumor cells. Cripto-1 (CR-1), a member of the epidermal growth factor-CFC protein family increases migration of cells in vitro. Here the expression of molecular markers and signaling molecules characteristic of EMT were assessed in mammary gland hyperplasias and tumors from mice expressing the human CR-1 transgene by the MMTV promoter (MMTV-CR-1) and in mouse mammary epithelial cell line HC-11 overexpressing CR-1 (HC-11/CR-1). Western blot analysis showed decreased expression of E-cadherin in MMTV-CR-1 tumors and in HC-11/CR-1 cells. The expression of N-cadherin, vimentin, cyclin-D1, and of the zinc-finger transcription factor, snail, was increased in MMTV-CR-1 tumors. Increased snail mRNA was also found in HC-11/CR-1 cells. Expression of phosphorylated (P)-c-Src, P-focal adhesion kinase (FAK), P-Akt, P-glycogen synthease kinase 3beta (GSK-3beta), dephosphorylated (DP)-beta-catenin, and various integrins such as, alpha 3, alpha v, beta 1, beta 3, and beta 4 was also increased in MMTV-CR-1 tumors. Immunohistochemistry showed positive staining for vimentin, N-cadherin, cyclin-D1, smooth muscle actin, fibronectin, snail, and beta-catenin in MMTV-CR-1 tumor sections. HC-11/CR-1 cells treated with the c-Src inhibitor PP2 reduced the expression of P-c-Src and of P-FAK, P-Akt, P-GSK-3beta, DP-beta-catenin all known to be activated by c-Src. Migration of HC-11/CR-1 cells was also reduced by PP2 treatment. These results suggest that CR-1 may play a significant role in promoting the increased expression of markers and signaling molecules associated with EMT.