gebhart/patrepeval huggingface dataset:
A simple interfacial pH detection method for cationic amphiphilic self-assemblies utilizing a Schiff-base molecule (2016)

A simple pH-sensing method for cationic micelle and vesicle interfaces is introduced, utilizing a Schiff-base molecule, 2-((4H-1,2,4-triazol-4-ylimino)methyl)-6-(hydroxymethyl)-4-methylphenol (AH). AH containing a phenolic moiety was obtained by the reaction between 4-amino-4H-1,2,4-triazole containing polar O- and N-centres with opposite polarity to the cationic interface and 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde. The acid/base equilibrium of AH was investigated at the interfaces of cetrimonium bromide (CTAB) micelles, tri-block-copolymeric micelles (TBPs) and large unilamellar vesicles (LUVs) of different lipid compositions using steady state UV-Vis absorption spectroscopy. AH interacted strongly with the micelle and vesicle interfaces, according to the binding studies with LUV. A larger amount of AH proton dissociation was observed when localized at the interface of micelles and vesicles compared to that in the bulk phase, indicating that the pH values at the cationic interfaces are higher than in the bulk phase. The pH values were about 2.2 and 1.6 units higher at the CTAB and TBP micelle interfaces, respectively, than the bulk pH. The pH variation decreased from 2.4 to 1.5 units by increasing the neutral 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid content from 0 to 50% in the cationic dimethyldioctadecylammonium (DDAB) LUV, indicating that the interfacial positive charges are responsible for the higher interfacial pH. Detailed structural and absorption characteristics of neutral AH and its anionic A(-) forms were investigated by fluorescence spectroscopic measurements and DFT based theoretical calculations. The present simple pH detection method may be applied to various biological micelle and vesicle interfaces.
LLC series resonant high-frequency sinusoidal power supplier (2010)

This paper presents an LLC series resonant high-frequency sinusoidal power supplier for contactless power transmission system utilizing the magnetizing inductance and the leakage inductance of contactless coupled transformer. The design of system's parameters is under 2mm air gap of contactless coupled transformer and utilizes microchip dsPIC30F4011 to track resonance tank voltage and current phase in order to maintain operation of circuit resonant frequency to ensure that circuit can provide maximum power output for various loads. Finally, a 1kW prototype is designed and implemented to access the performance of the proposed LLC series resonant high-frequency sinusoidal power supplier. The proposed circuit also compares with the traditional frequency fixed high-frequency sinusoidal power supplier. The experimental result shows that the proposed circuit can provide maximum power output for various loads and the efficiency is about 95%.
Quality of Red Blood Cells Using Autotransfusion Devices: A Comparative Analysis (2003)

Cell salvage devices are routinely used to process and wash red blood cells (RBCs) shed during surgical interventions. Although the principle theory of cell saving is the same, the actual process to achieve this is very different from one device to another. The purpose of this study was to compare the quality of washed, concentrated RBC produced by five very different cell-saving devices, specifically the Cobe BRAT 2, Medtronic Sequestra 1000, Haemonetics Cell Saver 5, Medtronic Autolog, and the Fresenius CATS. Reservoir and washed red blood cells were analyzed for hematocrit (Hct), platelets (PLT), leukocytes (WBC), potassium (K+), heparin, plasma-free hemoglobin (PFH), RBC mass recovery and recovery rate. The Haemonetics and BRAT 2 had the highest RBC recovery. All devices adequately removed heparin and potassium. The Medtronic Autolog had the highest removal of platelets and PFH; whereas, the BRAT had the lowest. Although the Autolog had the highest leukocyte removal, leukocytes were not adequately washed out by any of the autotransfusion devices. In conclusion, although all cell-saving devices use the same theory of centrifugation, the actual quality of the washed RBC product differs widely from one device to another.
Simultaneous Synthesis of Diamond and Hydrogen (2019)

A relationship between diamond synthesis and hydrogen production in in-liquid plasma method have been investigated. Approximately 60 % energy can be recovered by collecting hydrogen gas made by ingredient solution decomposition. The relationship is trade-off. When higher energy is used to maintain the substrate temperature, the hydrogen production rate gets faster, but the diamond synthesis rate gets slower. To increase diamond synthesis rate, a method should be established which maintains the substrate temperature by lower energy and generates less hydrogen gas.
Using Domain Top-page Similarity Feature in Machine Learning-Based Web Phishing Detection (2010)

This paper presents a study on using a concept feature to detect web phishing problem. Following the features introduced in Carnegie Mellon Anti-phishing and Network Analysis Tool (CANTINA), we applied additional domain top-page similarity feature to a machine learning based phishing detection system. We preliminarily experimented with a small set of 200 web data, consisting of 100 phishing webs and another 100 non-phishing webs. The evaluation result in terms of f-measure was up to 0.9250, with 7.50% of error rate.
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport (2002)

Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, and mutations in neurofilaments have been linked to some forms of CMT. Neurofilaments are the major intermediate filaments of neurones, but the mechanisms by which the CMT mutations induce disease are not known. Here, we demonstrate that CMT mutant neurofilaments disrupt both neurofilament assembly and axonal transport of neurofilaments in cultured mammalian cells and neurones. We also show that CMT mutant neurofilaments perturb the localization of mitochondria in neurones. Accumulations of neurofilaments are a pathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and diabetic neuropathy. Our results demonstrate that aberrant neurofilament assembly and transport can induce neurological disease, and further implicate defective neurofilament metabolism in the pathogenesis of human neurodegenerative diseases.
A 28-Gb/s 4-Tap FFE/15-Tap DFE Serial Link Transceiver in 32-nm SOI CMOS Technology (2012)

This paper presents a 28-Gb/s transceiver in 32-nm SOI CMOS technology for chip-to-chip communications over high-loss electrical channels such as backplanes. The equalization needed for such applications is provided by a 4-tap baud-spaced feed-forward equalizer (FFE) in the transmitter and a two-stage peaking amplifier and 15-tap decision-feedback equalizer (DFE) in the receiver. The transmitter employs a source-series terminated (SST) driver topology which doubles the speed of existing half-rate designs. The high-frequency boost provided by the peaking amplifier is enhanced by adopting a structure with capacitively coupled parallel input stages and active feedback. A capacitive level-shifting technique is introduced in the half-rate DFE which allows a single current-integrating summer to drive the four parallel paths used for speculating the first two DFE taps. Error-free signaling at 28 Gb/s is demonstrated with the transceiver over a channel with 35 dB loss at half-baud frequency. In a four-port core configuration, the power consumption at 28 Gb/s is 693 mW/lane.
V˙o 2 kinetics reveal a central limitation at the onset of subthreshold exercise in heart transplant recipients (2000)

Because the cardiocirculatory response of heart transplant recipients (HTR) to exercise is delayed, we hypothesized that their O(2) uptake (VO(2)) kinetics at the onset of subthreshold exercise are slowed because of an impaired early "cardiodynamic" phase 1, rather than an abnormal subsequent "metabolic" phase 2. Thus we compared the VO(2) kinetics in 10 HTR submitted to six identical 10-min square-wave exercises set at 75% (36 +/- 5 W) of the load at their ventilatory threshold (VT) to those of 10 controls (C) similarly exercising at the same absolute (40 W; C40W group) and relative load (67 +/- 14 W; C67W group). Time-averaged heart rate, breath-by-breath VO(2), and O(2) pulse (O(2)p) data yielded monoexponential time constants of the VO(2) (s) and O(2)p increase. Separating phase 1 and 2 data permitted assessment of the phase 1 duration and phase 2 VO(2) time constant (). The VO(2) time constant was higher in HTR (38.4 +/- 7.5) than in C40W (22.9 +/- 9.6; P < or = 0. 002) or C67W (30.8 +/- 8.2; P < or = 0.05), as was the O(2)p time constant, resulting from a lower phase 1 VO(2) increase (287 +/- 59 vs. 349 +/- 66 ml/min; P < or = 0.05), O(2)p increase (2.8 +/- 0.6 vs. 3.6 +/- 1.0 ml/beat; P < or = 0.0001), and a longer phase 1 duration (36.7 +/- 12.3 vs. 26.8 +/- 6.0 s; P < or = 0.05), whereas the was similar in HTR and C (31.4 +/- 9.6 vs. 29.9 +/- 5.6 s; P = 0.85). Thus the HTR have slower subthreshold VO(2) kinetics due to an abnormal phase 1, suggesting that the heart is unable to increase its output abruptly when exercise begins. We expected a faster in HTR because of their prolonged phase 1 duration. Because this was not the case, their muscular metabolism may also be impaired at the onset of subthreshold exercise.
SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. (2014)

Pim-1 mediates the biological effect of SGI-1776 in human ovarian cancer HO-8910 cells, suggesting Pim-1 might be a novel target for human ovarian cancer.
Stereochemical Studies on the Making and Unmaking of Isopentenyl Diphosphate in Different Biological Systems (2004)

To investigate the unknown stereochemical course of the reaction catalyzed by the type-II isomerase, which interconverts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), a sample of [1,2-(13)C2]-IPP stereospecifically labelled with 2H at C2 was prepared by incubating a D2O solution of (E)-4-hydroxy-3-methyl[1,2-(13)C2]but-2-enyl diphosphate with a recombinant IspH protein of Escherichia coli in the presence of NADH as a reducing agent and flavodoxin as well as flavodoxin reductase as auxiliary proteins. As monitored by 13C-NMR spectroscopy, treatment of the deuterated IPP with either type-I or type-II IPP isomerase resulted in the formation of DMAPP molecules retaining all the 2H label of the starting material. From the known stereochemical course of the type-I isomerase-catalyzed reaction, one has to conclude that the label introduced from D2O in the course of the IspH reaction resides specifically in the H(Si)-C2 position of IPP and that the two isomerases mobilize specifically the same H(Re)-C2 ligand of their common IPP substrate. The outcome of an additional experiment, in which unlabelled IPP was incubated in D2O with the type-II enzyme, demonstrates that the two isomerases also share the same preference in selecting for their reaction the (E)-methyl group of DMAPP.
Coherent Control of Total Transmission of Light through Disordered Media (2014)

We used wavefront shaping to enhance/suppress the transmission of coherent light through open highly scattering media. The total transmission was varied by one order of magnitude as a result of mesoscopic correlations of coherent transport.
VS01.07: THORACOSCOPIC ESOPHAGECTOMY WITH A HYBRID OF THE PRONE AND LEFT LATERAL DECUBITUS POSITIONS FOR ESOPHAGEAL CARCINOMA (2018)

Abstract Description Because esophagectomy with radical lymphadenectomy is highly invasive, thoracoscopic esophagectomy (TE) is attracting attention as a less invasive procedure. We first performed TE with the left decubitus position in 1996. In 2009 we developed a hybrid of the prone and left lateral decubitus positions for TE, and a total of 420 patients underwent TE with a hybrid position. We introduced TE with a hybrid position for the following three reasons: (1) Mobilization and lymphadenectomy around the middle and lower esophagus are easier in the prone position. Thanks to artificial pneumothorax and the gravity, the middle and lower mediastinum are opened, and which give us good surgical field. (2) Lymphadenectomy along the left recurrent laryngeal nerve (RLN) is more reliable and precise when performed in the left lateral decubitus position. We can dissect lymph node around the RLN higher position in the upper mediastinum. (3) Unexpected events requiring conversion to thoracotomy (e.g. massive bleeding, injury of other organs, dense intrathoracic adhesion, resection of adjacent organs) are easier to deal with in the left lateral decubitus position. The patient is fixed on the operating table with the semi-prone position and we can easily change patient positions from the left lateral decubitus position to the prone position and vice versa using rotation system of the operation table. The upper mediastinal procedure including lymphadenectomy along the right and left RLN is performed with the patient in the left lateral decubitus position, while the middle and lower mediastinal procedures are performed with the patient in the prone position with artificial pneumothorax (7mmHg). The abdominal procedures have beenwere performed by hand-assisted laparoscopic surgery (HALS) and gastric tube reconstruction in thethrough a posterior mediastinal route was performed as s a standard surgical procedure in our institution. The magnifying effect of thoracoscope enables us to perform more precise surgery and preserve nerve and vessels, and a hybrid position is thought to be feasible and effective methods. Disclosure All authors have declared no conflicts of interest.
Advanced Technologies for Wastewater Treatment (2022)

Presently, wastewater treatment is a growing and essential topic in water purification. Many factors, such as increasing population, industrialization, urbanization, etc., are majorly responsible for the discharge of different pollutants into the water resources. Previously, many traditional wastewater treatment techniques, such as ion exchange, thermal treatment adsorption, coagulation, electrochemical degradation, and chemical precipitation, were introduced. The mentioned techniques have some drawbacks, such as high-energy demand, production of by-products, toxic effects, cost issues, etc., which make them inefficient for cleaning water. A few important and effective approaches are summarized in this chapter by discussing comprehensive literature based on the wastewater treatment process. Among the abovementioned techniques, the microbial fuel cell (MFC) is considered an effective and effective approach to treating wastewater and has recently attracted researchers and academicians from all over the world. MFCs are a bioelectrochemical approach in which bacterial species serve as biocatalysts for the oxidation of organic matters and reduce the heavy metal content, which leads to the generation of electricity and concurrently cleaning of the wastewater. In this chapter, the role of MFCs in the field of wastewater treatment is briefly summarized. Finally, the concluding remarks of the literature survey and future recommendations are discussed.
Detecting Production Tubing Leak by Time Resolved Geochemical Analysis of Oils (1995)

Abstract Many multiple completion wells in the Gulf Coast often develop tubing string communication through leaks that may not be detected by changes in the production log of a well. Routine geochemical analyses of reservoir fluids, however, can provide an early indication of such problems and allow timely corrective action. This paper describes detection of production tubing leak by several time re-solved geochemical analyses of oils. It demonstrates that the geochemical technique is an effective and inexpensive tool for monitoring well performance. The technique is also capable to quantitatively determine mixes of commingled production caused by the plumbing problem.
Ultrasensitive immunochromatographic strip for detection of cyproheptadine (2018)

ABSTRACTUsing immunological and cell fusion technology, group-specific monoclonal antibodies were produced against cyproheptadine. The 50% inhibitory concentration of the antibody for cyproheptadine was 0.37 ng/mL, the linear range was 0.16–0.85 ng/mL, and recoveries of antibody in spiked negative pig urine were 80–120%. An ultrasensitive immunochromatographic strip, based on the antibody, was developed for the rapid detection of cyproheptadine in pig urine. The test strip had a cut-off value of 5 ng/mL.
Malware Detection in Android-Based Mobile Environments Using Optimum-Path Forest (2015)

Nowadays, people use smartphones and tablets with the very same purposes as desktop computers: web browsing, social networking and home-banking, just to name a few. However, we are often facing the problem of keeping our information protected and trustworthy. As a result of their popularity and functionality, mobile devices are a growing target for malicious activities. In such context, mobile malwares have gained significant ground since the emergence and growth of smartphones and handheld devices, becoming a real threat. In this paper, we introduced a recently developed pattern recognition technique called Optimum-Path Forest in the context of malware detection, as well we present "DroidWare", a new public dataset to foster the research on mobile malware detection. In addition, we also proposed to use Restricted Boltzmann Machines for unsupervised feature learning in the context of malware identification.
List of references (1998)

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Reconstitution of the Iterative Type II Polyketide Synthase for Tetracenomycin F2 Biosynthesis (1998)

The tetracenomycin polyketide synthase (TCM PKS), a type II complex, produces TCM F2, a precursor of TCM C in Streptomyces glaucescens, and consists of at least the TcmK, -L, -M, and -N proteins. The TcmK/TcmL ketosynthase subunits were purified from overexpression of their genes in Streptomyces lividans. TcmK (calculated molecular mass 45 kd) and TcmL (calculated molecular mass 42 kd) function as a heterodimeric alphabeta complex based on observing that only the purified complex complemented TCM PKS activity in protein extracts made from strains bearing tcmK or tcmL deletion mutants to make TCM F2 in vitro, and that the molecular mass of the purified complex was 90 kd as estimated by gel filtration chromatography. The TCM PKS activity was reconstituted with purified protein components, indicating that the minimal set of proteins required to make TCM F2 included the ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). The MAT was required to catalyze the transacylation between malonyl-CoA and TcmM, although a relatively slow spontaneous transacylation also occurred in a reaction without the MAT. Acetyl-CoA, the proposed starter unit for the TCM PKS, was not required for the production of TCM F2 in vitro, although it could be incorporated into this polyketide to a small extent. TcmJ, a PKS protein without a known function, greatly increased the production of TCM F2 but could not replace TcmN as a cyclase in the reconstituted system.
Stable Golgi-Mitochondria Complexes and Formation of Golgi Ca2+ Gradients in Pancreatic Acinar Cells (2005)

We have determined the localization of the Golgi with respect to other organelles in living pancreatic acinar cells and the importance of this localization to the establishment of Ca(2+) gradients over the Golgi. Using confocal microscopy and the Golgi-specific fluorescent probe 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine, we found Golgi structures localizing to the outer edge of the secretory granular region of individual acinar cells. We also assessed Golgi positioning in acinar cells located within intact pancreatic tissue using two-photon microscopy and found a similar localization. The mitochondria segregate the Golgi from lateral regions of the plasma membrane, the nucleus, and the basal part of the cytoplasm. The Golgi is therefore placed between the principal Ca(2+) release sites in the apical region of the cell and the important Ca(2+) sink formed by the peri-granular mitochondria. During acetylcholine-induced cytosolic Ca(2+) signals in the apical region, large Ca(2+) gradients form over the Golgi (decreasing from trans- to cis-Golgi). We further describe a novel, close interaction of the peri-granular mitochondria and the Golgi apparatus. The mitochondria and the Golgi structures form very close contacts, and these contacts remain stable over time. When the cell is forced to swell, the Golgi and mitochondria remain juxtaposed up to the point of cell lysis. The strategic position of the Golgi (closer to release sites than the bulk of the mitochondrial belt) makes this organelle receptive to local apical Ca(2+) transients. In addition the Golgi is ideally placed to be preferentially supplied by ATP from adjacent mitochondria.
Smallness for Gestational Age Is Associated with Persistent Change in Insulin-Like Growth Factor I (IGF-I) and the Ratio of IGF-I/IGF-Binding Protein-3 in Adulthood (2005)

Serum IGF-I concentrations and the IGF-I/IGFBP-3 ratio are lower in adult subjects born SGA. Although the origin of this persisting alteration of the IGF-IGFBP axis in adulthood needs to be elucidated, its potential contribution to the long-term metabolic and cardiovascular complications associated with fetal growth restriction is important to consider in the future.
$\texttt{GradICON}$: Approximate Diffeomorphisms via Gradient Inverse Consistency (2022)

We present an approach to learning regular spatial transformations between image pairs in the context of medical image registration. Contrary to optimization-based registration techniques and many modern learning-based methods, we do not directly penalize transformation irregularities but instead promote transformation regularity via an inverse consistency penalty. We use a neural network to predict a map between a source and a target image as well as the map when swapping the source and target images. Different from existing approaches, we compose these two resulting maps and regularize deviations of the $\bf{Jacobian}$ of this composition from the identity matrix. This regularizer -- $\texttt{GradICON}$ -- results in much better convergence when training registration models compared to promoting inverse consistency of the composition of maps directly while retaining the desirable implicit regularization effects of the latter. We achieve state-of-the-art registration performance on a variety of real-world medical image datasets using a single set of hyperparameters and a single non-dataset-specific training protocol.
Prevention of Antigenically Drifted Influenza by Inactivated and Live Attenuated Vaccines (2006)

In the 2004-2005 season, in which most circulating viruses were dissimilar to those included in the vaccine, the inactivated vaccine was efficacious in preventing laboratory-confirmed symptomatic illnesses from influenza in healthy adults. The live attenuated vaccine also prevented influenza illnesses but was less efficacious. (ClinicalTrials.gov number, NCT00133523.)
Supplementary Table 1 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells (2023)

Supplementary Table 1 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells