gebhart/patrepeval huggingface dataset:
Considerations for Safe Innovation: The Case of Graphene (2017)

The terms "Safe innovation" and "Safe(r)-by-design" are currently popular in the field of nanotechnology. These terms are used to describe approaches that advocate the consideration of safety aspects already at an early stage of the innovation process of (nano)materials and nanoenabled products. Here, we investigate the possibilities of considering safety aspects during various stages of the innovation process of graphene, outlining what information is already available for assessing potential hazard, exposure, and risks. In addition, we recommend further steps to be taken by various stakeholders to promote the safe production and safe use of graphene.
Signaling Lymphocytic Activation Molecule Is Expressed on Mature CD83+ Dendritic Cells and Is Up-Regulated by IL-1β (2001)

Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DC). However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1beta. Addition of IL-1beta to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1.
Bioluminescence-mediated longitudinal monitoring of adipose-derived stem cells in a large mammal ex vivo organ culture (2015)

Recently, ex vivo three-dimensional organ culture systems have emerged to study the physiology and pathophysiology of human organs. These systems also have potential as a translational tool in tissue engineering; however, this potential is limited by our ability to longitudinally monitor the fate and action of cells used in regenerative therapies. Therefore, we investigated luciferase-mediated bioluminescence imaging (BLI) as a non-invasive technique to continuously monitor cellular behavior in ex vivo whole organ culture. Goat adipose-derived stem cells (gADSCs) were transduced with either Firefly luciferase (Fluc) or Gaussia luciferase (Gluc) reporter genes and injected in isolated goat intervertebral discs (IVD). Luciferase activity was monitored by BLI for at least seven days of culture. Additionally, possible confounders specific to avascular organ culture were investigated. Gluc imaging proved to be more suitable compared to Fluc in monitoring gADSCs in goat IVDs. We conclude that BLI is a promising tool to monitor spatial and temporal cellular behavior in ex vivo organ culture. Hence, ex vivo organ culture systems allow pre-screening and pre-validation of novel therapeutic concepts prior to in vivo large animal experimentation. Thereby, organ culture systems can reduce animal use, and improve the speed of innovation by overcoming technological, ethical and financial challenges.
Application of a Color Change Coating to Evaluate Flow Velocity Distribution and Wall Shear Stress of Fan Blade (2021)

A mass transfer method has been employed to characterize tangential flow velocity around fan blades. In the current research, two commercial air-conditioning fan blade samples have been investigated. The blade surfaces were covered with a 10 μm yellow coating by a spray method. The fan and a camera are driven by a motor and shaft system that can synchronize the rotational speed. Therefore, a relative stay still image of the fan blade during rotation can be obtained. Subsequently, a small amount (50 ppmv) of ammonia has been injected into an environmental chamber that has the fan installed and rotating. The coating material on the blade surfaces absorbs the ammonia from the airflow and responds with a color change from yellow to blue. At the same time, the color change was recorded by the camera. The surface color change can be quantified by image processing which represents the local mass transfer. According to the fluid mechanics and analogy between mass transfer, heat transfer, and Colburn’s relation for turbulent flow, local tangential flow velocity distribution at the external of the boundary layer on the blade surface can be quantified. Thereafter, friction factor and wall shear stress can be calculated accordingly. Comparing to other experimental and computational methods, this new experimental method provides a robust way to evaluate turbulent flow velocity around the rotational fan blades. The results show this method is promising to be employed to evaluate and optimize fan systems to improve efficiency and reduce noise.
Innovative methodology for point-of-care circulating cathodic antigen with rapid urine concentration for use in the field for detecting low Schistosoma mansoni infection and for control of cure with high accuracy (2018)

The improvement of conventional POC methodology by a fast and simple urine concentration step provided not only an increase in its accuracy before and after praziquantel treatment, but also preserved its applicability in low-prevalence endemic areas, allowing the definition of trace readings as negative cases.
Supplementary Figure from Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti–PD-1 Immune Checkpoint Blockade (2023)

Supplementary Figure from Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti–PD-1 Immune Checkpoint Blockade
SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity (2022)

Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower motor neurons. The clinical phenotype of ALS shows inter- and intrafamilial heterogeneity. The aim of the study was to analyze the relations between individual SOD1 mutations and the clinical presentation using in silico methods to assess the SOD1 mutations severity. We identified SOD1 causative variants in a group of 915 prospectively tested consecutive Polish ALS patients from a neuromuscular clinical center, performed molecular modeling of mutated SOD1 proteins and in silico analysis of mutation impact on clinical phenotype and survival analysis of associations between mutations and hazard of clinical end-points. Fifteen SOD1 mutations were identified in 21.1% familial and 2.3% sporadic ALS cases. Their effects on SOD1 protein structure and functioning inferred from molecular modeling and in silico analyses correlate well with the clinical data. Molecular modeling results support the hypothesis that folding intermediates rather than mature SOD1 protein give rise to the source of cytotoxic conformations in ALS. Significant associations between type of mutation and clinical end-points were found.
Pedestrian Recognition by Using a Dynamic Modality Selection Approach (2015)

Despite many years of research, pedestrian recognition is still a difficult, but very important task. It was proved that concatenating information from multi-modality images improves the recognition accuracy, but with a high computational cost. We present a modality selection approach, which is able to dynamically select the most discriminative modality for a given image and furthermore use it in the classification process. Firstly, we extract kernel descriptor features from a given image in three modalities: intensity, depth and flow. Secondly, we dynamically determine the most suitable modality for that image using both: a modality pertinence classifier and a decision confidence indicator. Thirdly, we classify the image in the selected modality using a linear SVM approach. Numerical experiments are performed on the Daimler benchmark dataset consisting of pedestrian and non-pedestrian bounding boxes captured in outdoor urban environments and indicate that our model outperforms all the individual-modality classifiers and the model based on a posterior fusion of multi-modality decisions. Moreover, the proposed selection model is a promising and less computational expensive alternative to the concatenation of multi-modality features prior to classification.
Results From a Parametric Acoustic Liner Experiment Using P and W GEN1 HSR Mixer/Ejector Model (2004)

This report documents the results of an acoustic liner test performed using a Gen 1 HSR mixer/ejector model installed on the Jet Exit Rig in the Nozzle Acoustic Test Rig in the Aeroacoustic Propulsion Laboratory or NASA Glenn Research Center. Acoustic liner effectiveness and single-component thrust performance results are discussed. Results from 26 different types of single-degree-of-freedom and bulk material liners are compared with each other and against a hardwall baseline. Design parameters involving all aspects of the facesheet, the backing cavity, and the type of bulk material were varied in order to study the effects of these design features on the acoustic impedance, acoustic effectiveness and on nozzle thrust performance. Overall, the bulk absorber liners are more effective at reducing the jet noise than the single-degree-of-freedom liners. Many of the design parameters had little effect on acoustic effectiveness, such as facesheeet hole diameter and honeycomb cell size. A relatively large variation in the impedance of the bulk absorber in a bulk liner is required to have a significant impact on the noise reduction. The thrust results exhibit a number of consistent trends, supporting the validity of this new addition to the facility. In general, the thrust results indicate that thrust performance benefits from increased facesheet thickness and decreased facesheet porosity.
Self-Organizing Peer-To-Peer Middleware for Healthcare Monitoring in Real-Time (2017)

As the number of elderly persons with chronic illnesses increases, a new public infrastructure for their care is becoming increasingly necessary. In particular, technologies that can monitoring bio-signals in real-time have been receiving significant attention. Currently, most healthcare monitoring services are implemented by wireless carrier through centralized servers. These services are vulnerable to data concentration because all data are sent to a remote server. To solve these problems, we propose self-organizing P2P middleware for healthcare monitoring that enables a real-time multi bio-signal streaming without any central server by connecting the caregiver and care recipient. To verify the performance of the proposed middleware, we evaluated the monitoring service matching time based on a monitoring request. We also confirmed that it is possible to provide an effective monitoring service by evaluating the connectivity between Peer-to-Peer and average jitter.
High FDG Uptake in Sclerosing Hemangioma (2005)

A 42 years old woman underwent F-18 FDG PET because of the incidentally detected lung mass on chest X-ray. PET/CT showed hypermetabolic lesion in the lung right upper lobe and the lung cancer was suspected because of the high FDG uptake. However, pathologic diagnosis was sclerosing hemangioma. There are few reports on the evaluation of sclerosing hemangioma using FDG PET. A report showed a slightly increased uptake (standardized uptake ratio of 1.8) (1), and another report showed unsatisfactory result (2). We suggest that sclerosing hemangioma could be seen as hypermetabolic lesion on the FDG PET.
Annealing study of gold films using scanning tunneling microscopy (1995)

We have studied thermal annealing effects on the surface morphology of 800 Å thick gold films, using scanning tunneling microscopy. The gold films were thermally evaporated onto glass substrates and were then measured with the scanning tunneling microscope at room temperature before and after annealing. The annealing treatments were done at temperatures between 200 and 500 °C and for periods ranging from 1 to 60 h. We present data showing the evolution of the average surface-grain size and rms roughness amplitude of the gold films as a function of annealing temperature and duration. Our data suggest that surface diffusion is the main process active at low annealing temperatures of 300 °C and below. The activation energy for surface self-diffusion of gold in our samples was around 1.1 eV. Other mechanisms seem to be dominant at higher temperatures.
Los niveles sanguíneos de cobre y su influencia en los indicadores reproductivos de la hembra bovina en las condiciones del trópico (2010)

"Se estudiaron 319 hembras bovinas lecheras, con cupremia espontánea (239) e inducida y/o provocada (80) para conocer la correlación entre los valores de la cupremia y los indicadores reproductivos. Se evaluó el riesgo relativo de la presentación de anestro y repetición de servicioen animales hipocuprémicos y en los suplementados con cobre (Cu). Se empleó la correlación y regresión simple para demostrar la relación del cobre con los indicadores reproductivos, y ANOVA para la comparación de las medias y comparaciones de proporciones para laspresentaciones de celo y gestaciones. El riesgo relativo se evaluó mediante los paquetes Epidat 3.1 y Win Episcope 2.0. La hipocupremia aumentó 4.93, 2.52 y 3.33 veces el riesgo de presentar anestro, repetición de servicio y problemas reproductivos totales, respectivamente. Se encontró una correlación negativa y significativa (P &lt; 0.001) entre la cupremia e indicadores reproductivos en novillas y vacas, en un rango de 9.8 ± 1.0 a 14.0 ± 0.9 ¿mo/L. Las dosis de 50 y 100 mg de Cu resultaron eficaces para incrementar la cupremia y mejorar los indicadores reproductivos. Mostraron además, efecto protector (P &lt; 0.001) para el anestro y (P &lt; 0.05) problemas reproductivos totales. Se concluye que existe una correlación negativa entre la hipocupremia y los indicadores reproductivos, aumentando el riesgo de presentar anestro, la repetición de servicio y los principales indicadores evaluados."
Intelligent sensor-model automated control of PMR-15 autoclave processing (1992)

An intelligent sensor model system has been built and used for automated control of the PMR-15 cure process in the autoclave. The system uses frequency-dependent FM sensing (FDEMS), the Loos processing model, and the Air Force QPAL intelligent software shell. The Loos model is used to predict and optimize the cure process including the time-temperature dependence of the extent of reaction, flow, and part consolidation. The FDEMS sensing system in turn monitors, in situ, the removal of solvent, changes in the viscosity, reaction advancement and cure completion in the mold continuously throughout the processing cycle. The sensor information is compared with the optimum processing conditions from the model. The QPAL composite cure control system allows comparison of the sensor monitoring with the model predictions to be broken down into a series of discrete steps and provides a language for making decisions on what to do next regarding time-temperature and pressure.
Future Directions for Vascular Access for Hemodialysis (2014)

Hemodialysis vascular access is at the same time both the "Lifeline" and the "Achilles Heel" of hemodialysis. This review will initially summarize the vascular biology of dialysis vascular access dysfunction and then use this information to describe some novel and innovative ways (including advances in the process of care for vascular access) to prevent this problem.
Extraction and Segmentation of Sputum Cells for Lung Cancer Early Diagnosis (2013)

Lung cancer has been the largest cause of cancer deaths worldwide with an overall 5-year survival rate of only 15%. Its symptoms can be found exclusively in advanced stages where the chances for patients to survive are very low, thus making the mortality rate the highest among all other types of cancer. The present work deals with the attempt to design computer-aided detection or diagnosis (CAD) systems for early detection of lung cancer based on the analysis of sputum color images. The aim is to reduce the false negative rate and to increase the true positive rate as much as possible. The early detection of lung cancer from sputum images is a challenging problem, due to both the structure of the cancer cells and the stained method which are employed in the formulation of the sputum cells. We present here a framework for the extraction and segmentation of sputum cells in sputum images using, respectively, a threshold classifier, a Bayesian classification and mean shift segmentation. Our methods are validated and compared with other competitive techniques via a series of experimentation conducted with a data set of 100 images. The extraction and segmentation results will be used as a base for a CAD system for early detection of lung cancer which will improve the chances of survival for the patient.
Impact of lenalidomide on collected hematopoietic myeloid and erythroid progenitors: peripheral stem cell collection may not be affected (2019)

Lenalidomide (LEN) is commonly used as part of induction therapy in transplant-eligible patients with multiple myeloma. However, LEN use is associated with increased chance of peripheral blood stem cell (PBSC) collection failure. This has led to early collection in patients receiving induction with LEN-containing regimens, and the use of mobilization agents such as plerixafor. Despite potential significant clinical implications, the impact of LEN on autograft composition is unclear. We examined the effect of LEN exposure on hematopoietic progenitors in collected grafts of 94 patients who underwent autologous stem cell transplantation (HSCT) at our institution. LEN exposure resulted in lower myeloid and erythroid progenitors in collected grafts, but this effect was not seen in patients who received plerixafor-based mobilization. Exposure to LEN did not affect PBSC collection, possibly due to high plerixafor use in our cohort (70%). LEN changes the composition of PBSC grafts; the clinical implication of this finding is unknown.
Differentiation of SCC Susceptibility with EIS of Alloy 182 in High Temperature Water (2021)

Electrochemical Impedance Spectroscopy (EIS) measurements were carried out in high temperature water with Ni-based Alloy-182. The aim was to correlate the EIS results with differences in Stress Corrosion Cracking (SCC) susceptibility that is present around the Ni-NiO transition. There was a clear difference between the EIS results at and away from the Ni-NiO transition. To make a more quantitative correlation a simple equivalent circuit was used to fit the experimental data. A clear correlation between the CPE exponent (n) and the SCC susceptibility could be obtained. Additionally, it was shown that the high frequency arc of the EIS data was related to the diffuse double layer
Petrous apex lesion following meningitis: management and discussion (2021)

A 9-year-old male with history of mixed hearing loss presented with petrous apex lesion following episode of meningitis. Serial imaging revealed persistence of the lesion necessitating biopsy to rule out malignancy. Biopsy revealed inflammatory changes. The management of petrous apex lesions following meningitis can be conservative but repeat imaging is necessary to rule out progression and to rule out neoplastic process.
The TomTom Congestion Index (2012)

Traffic congestion affects millions of people every day. It is an inconvenience for the average driver, leads to loss of billions of dollars for businesses worldwide and has an adverse effect on the environment in terms of carbon dioxide (CO2) emissions and increased fuel consumption. With the introduction of an international traffic congestion index, various organizations including metropolitan planning organizations, departments of transportation, etc. can more easily identify areas of concern and allocate resources to alleviate bottlenecks on the road network, to build new infrastructure and monitor change over time in a standardized way.
A 5400 Voice-Channels Single Side Band Amplitude Modulated Radio Relay System Operating in the 4 GHz Band (1980)

The present study intends to show the feasibility of a SSB-AM microwave link. A laboratory model of a transmitter-receiver working in the 3,8 - 4,2 GHz band was constructed and allows 5400 voice-channels to be transmitted for a 29 MHz-bandwidth channel. Subsets linearity and propagation selective fading problems were more specifically investigated.
Nucleotide sequence of the glucoamylase gene GLU1 in the yeast Saccharomycopsis fibuligera (1987)

The complete nucleotide sequence of the glucoamylase gene GLU1 from the yeast Saccharomycopsis fibuligera has been determined. The GLU1 DNA hybridized to a polyadenylated RNA of 2.1 kilobases. A single open reading frame codes for a 519-amino-acid protein which contains four potential N-glycosylation sites. The putative precursor begins with a hydrophobic segment that presumably acts as a signal sequence for secretion. Glucoamylase was purified from a culture fluid of the yeast Saccharomyces cerevisiae which had been transformed with a plasmid carrying GLU1. The molecular weight of the protein was 57,000 by both gel filtration and acrylamide gel electrophoresis. The protein was glycosylated with asparagine-linked glycosides whose molecular weight was 2,000. The amino-terminal sequence of the protein began from the 28th amino acid residue from the first methionine of the putative precursor. The amino acid composition of the purified protein matched the predicted amino acid composition. These results confirmed that GLU1 encodes glucoamylase. A comparison of the amino acid sequence of glucoamylases from several fungi and yeast shows five highly conserved regions. One homology region is absent from the yeast enzyme and so may not be essential to glucoamylase function.
Low-cost high-efficient 10-Watt X-band high-power amplifier (2009)

A high power X-band amplifier with an output power over 10 Watts and a Power Added Efficiency (PAE) in excess of 40 percent has been developed. The design was fabricated in a 0.25 ¿m pHEMT GaAs process (WIN Semiconductor PP25-01). The small die area in combination with a 6-inch wafer technology provides the possibility for low cost production of a high performance X-band T/R chipset.
'Spatially modulated emission' advances point-of-care diagnostics (2010)

A robust, compact, low-cost 'spatially modulated emission' technique delivers high signal-to-noise discrimination and brings practical optofluidic biodetection out of the centralized laboratory and closer to the patient's point of care.
Convergence of multiple RNA-silencing pathways on GW182/TNRC6 (2023)

The RNA-binding protein TRIM71/LIN-41 is a phylogenetically conserved developmental regulator that functions in mammalian stem cell reprogramming, brain development, and cancer. TRIM71 recognizes target mRNAs through hairpin motifs and silences them through molecular mechanisms that await identification. Here, we uncover that TRIM71 represses its targets through RNA-supported interaction with TNRC6/GW182, a core component of the miRNA-induced silencing complex (miRISC). We demonstrate that AGO2, TRIM71, and UPF1 each recruit TNRC6 to specific sets of transcripts to silence them. As cellular TNRC6 levels are limiting, competition occurs among the silencing pathways, such that the loss of AGO proteins or of AGO binding to TNRC6 enhances the activities of the other pathways. We conclude that a miRNA-like silencing activity is shared among different mRNA silencing pathways and that the use of TNRC6 as a central hub provides a means to integrate their activities.
Automatic verilog code generation through grammatical evolution (2005)

This work aims to investigate the automatic generation of Verilog code, representing digital circuits through Grammatical Evolution (GE). Preliminary tests using a simple full adder generation problem have been performed.