gebhart/patrepeval huggingface dataset:
Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature. (1989)

During the Workshop "The Thymus. Histophysiology and Dynamics in the Immune System', Rolduc, april 1989, a special workshop was hold to characterize monoclonal antibodies (mAb) to thymic epithelial cells (TEC) in thymus of man, mice, and rat. Twenty-five TEC-specific mAb's were evaluated for their immunohistological staining patterns on reference thymus, thymuses during ontogeny, various other organs (all tissues obtained from the species against the mAb was raised) and thymuses of other species. In this report only immunohistological results of reference thymuses and thymuses of other species are described. Based on the staining patterns on reference thymuses, mAb could be subdivided in 5 main groups. It is proposed to use these clusters of thymic epithelial staining patterns (CTES) to designate individual mAb, awaiting the possible incorporation in existing CD nomenclature for leucocyte differentiation antigens. The present immunohistological approach will be extended by additional analysis for which a protocol was designed. The ultimate goal of this TEC-mAb workshop is to get well-characterized reagents in the analysis of TEC-associated molecules with putative function in intrathymic T-cell processing.
Cholesterol-induced fluid-phase immiscibility in membranes. (1991)

The fluid-phase behavior of binary mixtures of cholesterol with phosphatidylcholines is investigated using magnetic resonance methods. Phospholipid biradicals provide the electron spin resonance spectroscopic resolution of two immiscible fluid phases in the dipalmitoylphosphatidylcholine-cholesterol system. Isotropic chemical shifts of the phospholipid carbonyl carbons in binary mixtures with cholesterol measured using solid-state high-resolution nuclear magnetic resonance methods furnish evidence for a putative hydrogen bond between the 3 beta-hydroxyl of cholesterol and the sn-2 carbonyl of the phospholipid. The location in the bilayer of cholesterol in the two fluid phases is determined by measuring spin label-enhanced spin-lattice relaxation rates of the 13C nuclei of both the phospholipid and cholesterol molecules. These results suggest, in a time-averaged sense, that in the cholesterol-poor fluid phase the cholesterol molecule essentially spans the bilayer, whereas in the cholesterol-rich fluid phase the molecule is present in both monolayers of the bilayer.
First observation of micrometeoroid differential ablation in the atmosphere (2009)

Every day, billions of microgram‐sized‐extraterrestrial particles enter and ablate in the upper layers of the Earth's atmosphere, depositing their mass in the mesosphere and lower thermosphere (MLT). This evaporated meteoric mass is the source of global layers of neutral metal atoms, sporadic E layers of metal ions, and meteoric smoke particles. Because their kinetic energy is insufficient to produce detectable optical emissions, these particles can only be observed using sensitive radars, which detect the plasma (i.e., electrons) either immediately surrounding the meteoroid (head‐echo), or left behind along its path (trail‐echo). Here we show that observed short‐scale temporal features in the radar returned signal from the meteor head‐echo are explained by differential ablation of the chemical constituents. These results represent the first observation of this mass‐loss process, indicating that this is the main mechanism through which the meteoric mass of micron‐sized particles is deposited in the MLT.
Aggressive early crystalloid resuscitation adversely affects outcomes in adult blunt trauma patients: An analysis of the Glue Grant database (2013)

BACKGROUND: Evidence suggests that aggressive crystalloid resuscitation is associated with significant morbidity in various clinical settings. We wanted to assess whether aggressive early crystalloid resuscitation adversely affects outcomes in adult blunt trauma patients. METHODS: Data were derived from the Glue Grant database. Our primary outcome measure was all-cause in-hospital mortality. Secondary outcomes included days on mechanical ventilation; intensive care unit (ICU) and hospital length of stay (LOS); inflammatory (acute lung injury and adult respiratory distress syndrome, or multiple-organ failure) and resuscitation-related morbidity (abdominal and extremity compartment syndromes or acute renal failure) and nosocomial infections (ventilator-associated pneumonia, bloodstream, urinary tract, and surgical site infections). RESULTS: In our sample of 1,754 patients, in-hospital mortality was not affected, but ventilator days (p < 0.001) as well as ICU (p = 0.009) and hospital (p = 0.002) LOS correlated strongly with the amount of crystalloids infused in the first 24 hours after injury. Amount of crystalloid resuscitation was also associated with the development of adult respiratory distress syndrome (p < 0.001), multiple-organ failure (p < 0.001), bloodstream (p = 0.001) and surgical site infections (p < 0.001), as well as abdominal (p < 0.001) and extremity compartment syndromes (p = 0.028) in a dose-dependent fashion, when age, Glasgow Coma Scale (GCS), severity of injury and acute physiologic derangement, comorbidities, as well as colloid and blood product transfusions were controlled for. CONCLUSION: Crystalloid resuscitation is associated with a substantial increase in morbidity, as well as ICU and hospital LOS in adult blunt trauma patients. LEVEL OF EVIDENCE: Therapeutic study, level III.
Application of Facial Feature Localization Using Constrained Local Models in Template-Based Caricature Synthesis (2009)

A three-step method for quasi-frontal face caricature generation is presented in the paper. First a CLM (Constrained Local Models) and CQF (Convex Quadratic Fitting) based face alignment approach is utilized to obtain initial locations of key facial features. Then facial components (eyebrow, eye, nose and mouth) are classified respectively into different categories defined by configuration and appearance in consistent with Chinese- Physiognomy. The mapping relationship between feature attributes and corresponding categories is learnt from a preclassified training set using the decision tree classification algorithm. Finally, separate facial feature cartoon templates are selected according to the classification results and then assembled to form an expressive caricature. Experimental results prove that the presented method is practical and robust for face caricature generation applications.
Establishing a paediatric airway epithelial model of acute wheezing illness (2022)

<b>Introduction:</b> Paediatric acute wheezing illness (AWI) airway models have not yet been established or characterised for intrinsic epithelial vulnerabilities, due to poor yield and culture survival. <b>Aim:</b> To establish and characterise a paediatric airway epithelial culture model of AWI. <b>Methods:</b> Nasal epithelial cells (NECs) sampled from children with AWI (n=6; 3 males; age 10.7±2.8) and community controls (n=6; 3 males; age 6.6±2.1) were cultured at air-liquid interface. Epithelial lineage markers (Cytokeratin (Ck)19, Ck5), vimentin, β-actin, β-tubulin, zonula occludens (ZO1) and rhinoviral receptors (ICAM1, LDLR, CDHR3) were assessed via qPCR. Barrier integrity and function was determined via trans-epithelial resistance and permeability assays. Basal inflammatory cytokine production (Interleukin (IL)6, -8) was measured via ELISA. <b>Results:</b> Similar gene expression was observed in both cohorts (AWI vs control (X ̅±SD) for Ck19 (2.88±1.21 vs 3.16±0.91), Ck5 (3.31±1.49 vs 3.51±1.78), vimentin (0.12±0.09 vs 0.15±0.10), β-actin (0.29±0.06 vs 0.28±0.06), ZO1 (0.0059±0.00089 vs 0.0054±0.0029), LDLR (0.69±0.32 vs 0.72±0.32), ICAM1 (0.23±0.24 vs 0.20±0.35) and CDHR3 (0.96±0.27 vs 1.61±0.94). β-tubulin was significantly lower the AWI cohort (7.17±2.56×10<sup>-6</sup> vs 2.27±1.37×10<sup>-5</sup>; p&lt;0.05). Similar trans-epithelial resistance (Ω.cm<sup>2</sup>) (274.87±76.20 vs 302.60±135.65; n=5), permeability (cm/sec) (14.58±9.62×10<sup>-4</sup> vs 72.25±116.48×10<sup>-4</sup>; n=5) and basal inflammatory cytokines (pg/ml/µg protein) (IL6: 1.57±1.85, n=4 vs 0.52±0.21, n=3; IL8: 7.33±3.42; n=4 vs 4.05±1.49; n=3) were observed. <b>Conclusion:</b> We successfully established a well-differentiated culture model of children with AWI that can be used for future studies.
Prosody and intrasyllabic timing in French (1994)

Durational variation associated with accentuation and final lengthening is examined in a corpus of articulatory data for French. Both factors are associated with measurable differences in acoustic duration. However two different articulatory strategies are employed to make these contrasts although both result in superficially longer and more displaced gestures.
Implementing declarative overlays (2005)

Overlay networks are used today in a variety of distributed systems ranging from file-sharing and storage systems to communication infrastructures. However, designing, building and adapting these overlays to the intended application and the target environment is a difficult and time consuming process.To ease the development and the deployment of such overlay networks we have implemented P2, a system that uses a declarative logic language to express overlay networks in a highly compact and reusable form. P2 can express a Narada-style mesh network in 16 rules, and the Chord structured overlay in only 47 rules. P2 directly parses and executes such specifications using a dataflow architecture to construct and maintain overlay networks. We describe the P2 approach, how our implementation works, and show by experiment its promising trade-off point between specification complexity and performance.
Infection of cultured human adrenal cells by different strains of HIV (1992)

These observations indicate that human adrenal cells are susceptible to HIV infection, and provide further evidence of the polytropic nature of the virus.
Effects of Sintering Conditions on Mechanical Properties of Mechanically Alloyed Tungsten Heavy Alloys (2000)

The effects of sintering conditions on the microstructural evolution and mechanical properties of mechanically alloyed tungsten heavy alloys were investigated. W, Ni and Fe powders were mechanically alloyed in a tumbler ball mill at a milling speed of 75 rpm, ball-to-powder ratio of 20∶1 and ball filling ratio of 15%. The mechanically alloyed powders were compacted and solid-state sintered at a temperature of 1300°C for 1 hour in a hydrogen atmosphere. The solid-state sintered tungsten heavy alloy was subsequently liquid-phase sintered at 1470°C with varying sintering times from 4 min to 90 min. The solid-state sintered tungsten heavy alloy showed fine tungsten particles of 3 μm in diameter and high relative density above 99%. The volume fraction of the W-Ni-Fe matrix phase was measured, as 11% and tungsten/tungsten contiguity was 0.74 in solid-state sintered tungsten heavy alloys. Mechanically alloyed and two-step sintered tungsten heavy alloys showed tungsten particles of 6–15 μm and a volume fraction of the W-Ni-Fe matrix phase of 16% and tungsten/tungsten contiguity of 0.40. The solid-state sintered tungsten heavy alloy exhibited a yield strength of about 1100 MPa due to its finer tungsten particles, while it showed low elongation and impact energy due to its large tungsten/tungsten contiguity. The yield strength of two-step sintered tungsten heavy alloys increased with the decreasing of tungsten particle size and volume fraction of the W-Ni-Fe matrix.
Characterization of a Dynamic Y2Ir2O7 Catalyst during the Oxygen Evolution Reaction in Acid (2022)

Reducing precious metal content and improving the efficiency of proton exchange membrane water electrolyzers is critical for producing renewable hydrogen cost-effectively. Mixed metal iridium oxide catalysts (AIrxOy, A = nonprecious metal) have demonstrated superior oxygen evolution reaction (OER) activity relative to IrO2 catalysts while utilizing less Ir. However, improved stability is required if these materials are to be implemented commercially. In this work, we use a combination of ex situ and in situ characterization techniques to study physical and electronic properties of Y2Ir2O7 as it evolves during OER in acidic electrolyte. We identify and quantify dissolution of Y and Ir, finding that this material exhibits similar stability to other reported mixed metal Ir oxides (104–105 molO2 evolved/molIr dissolved) and appears to become more stable over time. We find that the catalyst surface becomes enriched with Ir after electrochemical testing. We further monitored the Ir oxidation state in situ using high-energy resolution fluorescence detected X-ray absorption spectroscopy. Our results suggest that the Ir oxidation state is dynamic: an IrOx surface forms that is more oxidized than the bulk pyrochlore material but subsequently dissolves. Such detailed characterization of material properties can be used to develop design principles for improving catalyst stability.
Supplementary Table S2 from Diverse <i>BRCA1</i> and <i>BRCA2</i> Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer (2023)

&lt;p&gt;Sequencing statistics and non-synonymous somatic mutations identified in cfDNA and tumor tissue of ovarian and breast cancer patients included in this study.&lt;/p&gt;
Factoring games to isolate strategic interactions (2007)

Game theoretic reasoning about multi-agent systems has been made more tractable by algorithms that exploit various types of independence in agents' utilities. However, previous work has assumed that a game's precise independence structure is given in advance. This paper addresses the problem of finding independence structure in a general form game when it is not known ahead of time, or of finding an approximation when full independence does not exist. We give an expected polynomial time algorithm to divide a bounded-payout normal form game into factor games that isolate independent strategic interactions. We also show that the best approximate factoring can be found in polynomial time for a specific interaction that is not fully independent. Once known, factors aide computation of game theoretic solution concepts, including Nash equilibria (or ε-equilibria for approximate factors), in some cases guaranteeing polynomial complexity where previous bounds were exponential.
Research on mechanism of energy metabolism disorders of rat's hepatoxicity induced by saikosaponins (2011)

Alcohol eluent of saikosaponins can induce liver damage by restraining the respiratory function of mitochondria and effecting liver's energy metabolism. Other hepatoxicity mechanism still need to be discussed.
Combined supplementation with Lactobacillus sp. and Bifidobacterium thermacidophilum isolated from Tibetan pigs improves growth performance, immunity, and microbiota composition in weaned piglets (2023)

Probiotics, such as Lactobacillus and Bifidobacterium, promote growth in piglets by modulating gut microbiota composition and improving the host immune system. A strain of Lactobacillus sp. and Bifidobacterium thermacidophilum were previously isolated from fresh feces of Tibetan pigs. The effects of these isolated strains on growth performance, intestinal morphology, immunity, microbiota composition, and their metabolites were evaluated in weaned piglets. Thirty crossbred piglets were selected and fed either a basal diet (CON), a basal diet supplemented with aureomycin (ANT), or a basal diet supplemented with Lactobacillus sp. and B. thermacidophilum (LB) for 28 d. The piglets in the ANT and LB groups had significantly higher body weight gain than those in the CON group (P < 0.05). Piglets in the ANT and LB groups had regularly arranged villi and microvilli in the small intestine. Furthermore, they had improved immune function, as indicated by decreased serum concentrations of inflammatory cytokines (P < 0.05), improved components of immune cells in the blood, mesenteric lymph nodes, and spleen. Additionally, metagenomic sequencing indicated a significant shift in cecal bacterial composition and alterations in microbiota functional profiles following Lactobacillus sp. and B. thermacidophilum supplementation. Metabolomic results revealed that the metabolites were also altered, and Kyoto Encyclopedia of Genes and Genomes analysis revealed that several significantly altered metabolites were enriched in glycerophospholipid and cholesterol metabolism (P < 0.05). Furthermore, correlation analysis showed that several bacterial members were closely related to the alterations in metabolites, including Bacteroides sp., which were negatively correlated with triglyceride (16:0/18:0/20:4[5Z,8Z,11Z,14Z]), the metabolite that owned the highest variable importance of projection scores. Collectively, our findings suggest that combined supplementation with Lactobacillus sp. and B. thermacidophilum significantly improved the growth performance, immunity, and microbiota composition in weaned piglets, making them prospective alternatives to antibiotics in swine production.
De innovatieve arbeidsorganisatie in de zorg (2013)

status: Published
Soluble Fms-like tyrosine kinase-1 to placental growth factor ratio in mid-pregnancy as a predictor of preterm preeclampsia in asymptomatic pregnant women (2014)

The sFlt-1/PlGF ratio has the potential to predict early-onset and preterm preeclampsia at mid-pregnancy in asymptomatic women. However, care must be paid to the prevalence of early-onset preeclampsia in the population since low prevalence reduces PPV and may hamper clinical utility.
Structured vector bundles define differential K-theory (2008)

A equivalence relation, preserving the Chern-Weil form, is defined between connections on a complex vector bundle. Bundles equipped with such an equivalence class are called Structured Bundles, and their isomorphism classes form an abelian semi-ring. By applying the Grothedieck construction one obtains the ring K, elements of which, modulo a complex torus of dimension the sum of the odd Betti numbers of the base, are uniquely determined by the corresponding element of ordinary K and the Chern-Weil form. This construction provides a simple model of differential K-theory, c.f.Hopkins-Singer (2005), as well as a useful codification of vector bundles with connection.
Digested disorder (2014)

The current literature on intrinsically disordered proteins grows fast. To keep interested readers up to speed with this literature, we continue a "Digested Disorder" project and represent a new issue of reader's digest of the research papers and reviews on intrinsically disordered proteins. The only 2 criteria for inclusion in this digest are the publication date (a paper should be published within the covered time frame) and topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the third quarter of 2013; i.e., during the period of June, July, and September of 2013. Similar to previous issues, the papers are grouped hierarchically by topics they cover, and for each of the included paper a short description is given on its major findings.
6 Studies of spin-coated polymer films (2005)

Spin-coating is widely employed for the highly reproducible fabrication of thin film coatings over large areas with high structural uniformity. Research in recent years has extended the scope of spin-coating by chemically engineering the interface of support and solution to obtain specific structural order in the resulting supported thin films. This review will discuss both the fundamental physical and chemical processes governing the conventional spin-coating process and describe methodologies for the preparation of spin-coated polymer thin films. Furthermore, a range of advanced applications and recent developments within this field will be reviewed with focus on engineering chemical and topological structure during the coating process.
Determination of the ligamentous and contact forces in the human tibio-femoral joint using a three-dimensional dynamic anatomical model (2002)

This paper describes for the first time the three-dimensional dynamic response of the tibio-femoral joint when subjected to sudden external loads utilizing a three-dimensional dynamic anatomical model. This model consists of two body segments in contact (the femur and the tibia) executing a general three-dimensional dynamic motion within the constraints of the ligamentous structures. Each of the articular surfaces at the tibio-femoral joint was represented by a separate mathematical function. The joint ligaments were modeled as nonlinear elastic springs. The six-degrees-of-freedom joint motions were characterized using six kinematic parameters and ligamentous forces were expressed in terms of these six parameters. Model equations consist of nonlinear second order ordinary differential equations coupled with nonlinear algebraic constraints. An algorithm was developed to solve this Differential-Algebraic Equations (DAE) system employing a DAE solver, namely the Differential/Algebraic System Solver (DASSL) developed at Lawrence Livermore National Laboratory. Model calculations show that as the knee was flexed from 15/spl deg/ to 90/spl deg/, it underwent internal tibial rotation. However, in the first 15 degrees of knee flexion, this trend was reversed: the tibia rotated internally as the knee was extended from 15/spl deg/ to full extension. This finding is important since it is in agreement with the emerging thought of the need to re-evaluate the so called "screw-home mechanism".
P025 Expert Opinions to Develop a Sleep Intervention for Patients with Low Back Pain: A Nominal Group Study (2021)

Abstract Introduction Insomnia is a common comorbidity of low back pain. Research has investigated the use of cognitive behavioural therapy interventions for insomnia (CBT-I) to treat these conditions but show little effect on improving pain outcomes. This study sought the opinion of experts to explore how existing online CBT-I interventions could be optimised to improve sleep and pain outcomes in patients with comorbid insomnia and LBP. Methods This study was conducted using the nominal group technique, a structured meeting to generate ideas and rank priorities amongst a panel of experts. Musculoskeletal researchers (n=7) and clinicians (n=1), sleep researchers (n=2), and a consumer advocate (n=1) were purposively sampled to participate in a 2-hour online nominal group workshop. A quantitative analysis was conducted to rank ideas by their relative importance. A qualitative analysis was used to provide context on the highest ranked ideas. Results A total of 58 ideas were generated and subdivided into 11 primary categories, each of which contained a varying number of sub-ideas. The primary categories, personalisation of care, assessment guided management, understanding the user experience, personalised advice on physical and environmental factors, and continual re-assessment to guide management, were ranked one to five respectively and accounted for 73% of all votes from the panel. Discussion An intervention framework consisting of three interacting domains, personalisation of the intervention, assessment guided management, and user experience was proposed. This framework outlines recommendations that should be considered to improve online CBT-I interventions to treat patients with comorbid insomnia and low back pain.