gebhart/patrepeval huggingface dataset:
Design and analysis of coupling methods for modular endoprosthetic systems as an alternative to the conical coupling (2001)

Modular endoprostheses are often used in bone tumor management. However, the conical coupling that connects the various modules has several shortcomings. As an alternative, four new couplings have been developed. To find out if they have sufficient strength and show no movement during loading, each coupling was analysed using the finite element method. Bolt force and friction coefficient was varied to examine their influence. From the analysis it was concluded that coupling B, a dovetail coupling, meets all requirements and is the best alternative to the conical coupling. Sensitivity to bolt force and friction coefficient is very limited.
Buerger Disease (Thromboangiitis Obliterans) (2010)

Thromboangiitis obliterans, or Buerger disease, is a debilitating vascular disease with a well-known pronounced link to cigarette smoking and, more specifically, to the nicotine component of tobacco inhalation. Buerger disease is an inflammatory occlusive disorder that primarily affects the medium and small vessels of the extremities. In the present case report, a 46-year-old man, nonforthcoming smoker, presented to the authors' clinic with a deep ulcer at the head of the second metatarsal. Evidently, although the patient continued to smoke, the ulcer responded to therapy but regressed. Once the history was elaborated, the patient stopped smoking, and the ulcer healed completely within 2 months. Follow-up appointments proved to be unremarkable and to the authors' knowledge, there has not been a reoccurrence, and the patient remains tobacco-free.
Topological triple phase transition in non-Hermitian Floquet quasicrystals (2022)

Phase transitions connect different states of matter and are often concomitant with the spontaneous breaking of symmetries. An important category of phase transitions is mobility transitions, among which is the well known Anderson localization<sup>1</sup>, where increasing the randomness induces a metal-insulator transition. The introduction of topology in condensed-matter physics<sup>2-4</sup> lead to the discovery of topological phase transitions and materials as topological insulators<sup>5</sup>. Phase transitions in the symmetry of non-Hermitian systems describe the transition to on-average conserved energy<sup>6</sup> and new topological phases<sup>7-9</sup>. Bulk conductivity, topology and non-Hermitian symmetry breaking seemingly emerge from different physics and, thus, may appear as separable phenomena. However, in non-Hermitian quasicrystals, such transitions can be mutually interlinked by forming a triple phase transition<sup>10</sup>. Here we report the experimental observation of a triple phase transition, where changing a single parameter simultaneously gives rise to a localization (metal-insulator), a topological and parity-time symmetry-breaking (energy) phase transition. The physics is manifested in a temporally driven (Floquet) dissipative quasicrystal. We implement our ideas via photonic quantum walks in coupled optical fibre loops<sup>11</sup>. Our study highlights the intertwinement of topology, symmetry breaking and mobility phase transitions in non-Hermitian quasicrystalline synthetic matter. Our results may be applied in phase-change devices, in which the bulk and edge transport and the energy or particle exchange with the environment can be predicted and controlled.
Pharmacological and Physiological Growth Hormone (GH) Stimulation Tests to Predict Successful GH Therapy in Children (2009)

Although the current use of growth hormone (GH) stimulation tests (GHSTs) is still subject to debate, the tests are widely used to diagnose GH deficiency. This literature review evaluates primarily the sensitivity, specificity and reliability of GHSTs and secondarily their convenience. Single pharmacological tests typically address only a single pathway in the complex physiological regulation of GH secretion and are therefore characterized by lower sensitivity, specificity and reliability than combined pharmacological tests or physiological tests. In spite of the high levels of sensitivity, specificity and reliability, physiological tests require considerably more effort to perform, from the physician as well as from the child. Therefore, a need for an alternative, convenient, physiological GHST still remains. Oral ingestion of dietary protein is convenient in practice and may induce more physiological stimulation of GH secretion, hence may be a promising valuable addition to the existing GHSTs in GH deficiency.
Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation. (1999)

Recently several chromosomal translocations involved in myeloma cases and myeloma cell lines; i.e., t(11;14)(q13;q32), t('8;14)(q24;q32), t(4;14)(q16.3;q32.3), t(6;14)(p25;q32), and t(14;16)(q32.3;q23), have been identified. These translocations are considered to dysregulate genes which may be concerned with myelomagenesis; i.e., PRAD1/cyclin D1, the c-myc oncogene, FGFR3 (fibroblast growth factor receptor 3), MMSET (multiple myeloma SET domain), MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4), and the c-maf oncogene, respectively. However, the cellular biological roles of these genes have not yet been elucidated in myeloma cells. Because two of the seven human myeloma cell lines which were established at Kawasaki Medical School, Okayama, Japan, KMS-11 and KMS-18, have been proven to possess t(4;14)(q16.3;q32.3), we studied the expression levels of the FGFR3 gene in these seven cell lines and 13 primary myeloma specimens. The expression levels of 12 known FGF family genes (FGF-1 to 12) and 4 FGFR genes (FGFR1 to 4) were also examined in seven cell lines. In addition, the growth status of the KMS-11 and KMS-18 lines with FGF-1 or anti-FGF-4 neutralizing monoclonal antibody (MoAb) supplementation was investigated because FGF-1 and 4 are known as the principal ligands for FGFR3. FGFR3 overexpression was observed in both of the cell lines possessing t(4;14)(q16.3;q32.3) and in 3 of 13 case specimens. Anti-FGF-4 neutralizing MoAb caused significant growth inhibition in these two cell lines possessing t(4;14)(q16.3;q32.3). These findings indicate that t(4;14) (q16. 3;q32.3) may provide myeloma cells with a growth advantage via an autocrine mechanism between FGFR3 and FGF-4.
High-precision motion control method and practice for autonomous driving in complex off-road environments (2016)

In the last decade, autonomous driving technology has become an important research topic due to its potential economic and social benefits. There has been considerable research activities contributed to make the autonomous driving system adapt to complex environments. Motion control is vital to the overall autonomous driving system, especially when the autonomous vehicle is driving in complex off-road environments. The aim of our work in this paper is to develop a high-precision motion controller for autonomous driving system running on rugged mountain roads and sand roads. Different from most existing methods in which the motion control problem is decoupled into lateral control and longitudinal control. In this work, a coupling controller is designed for solving the motion control problem of autonomous driving system. Experiments in the real-world rugged mountain road and sand road environment have been conducted to demonstrate the high-precision performance and efficiency of the proposed motion controller.
DSEK: What You Need to Know About Endothelial Keratoplasty (2009)

DSEK: What You Need to Know About Endothelial Keratoplasty is the first text to explore the rapid evolvement of endothelial keratoplasty (EK) procedures. Endothelial keratoplasty is part of a revolution in corneal transplant surgery in which surgeons perform disease specific tissue replacement, as opposed to full thickness replacement of the cornea for all conditions. Today, patients are demanding EK instead of standard transplant methods because the newer methods are safer while the visual recovery is quicker and more predictable.DSEK provides a comprehensive background of EK, where it is today, and where it is headed in the future. Dr. Francis W. Price, who was the first to complete DSEK in the United States, along with Dr. Marianne Price have designed this text to offer a special emphasis on how to perform surgeries along with preventing and managing complications. In addition, a diverse group of contributing authors provides a wide array of insights and tips for better patient outcomes.This book includes current applications of DSEK and DSAEK; information on how to perform DMEK, the newest iteration of EK, including a step by step technique and post operative management; detailed discussion of air management for EK surgeries; and, new techniques of using glides in the Asian Eye.
The Efficacy of CD40 Ligand Blockade in Discordant Pig-to-Rat Islet Xenotransplantation Is Correlated with an Immunosuppressive Effect of Immunoglobulin (2005)

Immunosuppression with high doses of antibodies, monoclonal or polyclonal, in combination with CsA or TAC inhibits pig-to-rat islet xenograft rejection. No specific effect of co-stimulatory blockade with aCD40L could be observed. Instead, the results indicate a nonspecific immunosuppressive effect of high doses of antibodies in this model.
Structural and Electrochemical Studies of Rhombohedral Na2TiM(PO4)3 and Li1.6Na0.4TiM(PO4)3 (M: Fe, Cr) Phosphates (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Three-Dimensional Hydrogel Model Using Adipose-Derived Stem Cells for Vocal Fold Augmentation (2009)

Adipose-derived stem cells (ASCs) may provide a clinical option for rebuilding damaged superficial lamina propria of the vocal fold. We investigated the effects of five hydrogels (hyaluronic acid [HA], collagen, fibrin, and cogels of fibrin-collagen and fibrin-HA) on the differentiation of ASCs, with the long-term goal of establishing the conditions necessary for controlling the differentiation of ASC into the functional equivalent of superficial lamina propria fibroblasts. Human ASCs were isolated and characterized by fluorescence-activated cell sorting and real-time polymerase chain reaction. According to fluorescence-activated cell sorting and gene analysis, over 90% of isolated ASCs expressed adult stem cell surface markers and expressed adult stem cell genes. Scaffold-specific gene expression and morphology were assessed by culturing the ASCs in three-dimensional hydrogels. Twofold higher amounts of total DNA were detected in fibrin and cogel cultures than in collagen and HA cultures. Elastin expression was significantly higher in cells grown in fibrin-based gels than in cells grown in other gels. Cells grown in the cogels showed elongated morphology, expressed decorin marker, and exhibited glycosaminoglycan synthesis, which indicate ASC differentiation. Our data suggest that it may be possible to control the differentiation of ASCs using scaffolds appropriate for vocal fold tissue engineering applications. In particular, cogels of HA or collagen with fibrin enhanced proliferation, differentiation, and elastin expression.
S-vector: A discriminative representation derived from i-vector for speaker verification (2015)

Representing data in ways to disentangle and factor out hidden dependencies is a critical step in speaker recognition systems. In this work, we employ deep neural networks (DNN) as a feature extractor to disentangle and emphasize the speaker factors from other sources of variability in the commonly used i-vector features. Denoising autoencoder based unsupervised pre-training, random dropout fine-tuning, and Nesterov accelerated gradient based momentum is used in DNN training. Replacing the i-vectors with the resulting speaker vectors (s-vectors), we obtain superior results on NIST SRE corpora on a wide range of operating points using probabilistic linear discriminant analysis (PLDA) back-end.
Coding-Sequence Identification and Transcriptional Profiling of Nine AMTs and Four NRTs From Tobacco Revealed Their Differential Regulation by Developmental Stages, Nitrogen Nutrition, and Photoperiod (2018)

Although many members encoding different ammonium- and nitrate-transporters (AMTs, NRTs) were identified and functionally characterized from several plant species, little is known about molecular components for [Formula: see text]- and [Formula: see text] acquisition/transport in tobacco, which is often used as a plant model for biological studies besides its agricultural and industrial interest. We reported here the first molecular identification in tobacco (<i>Nicotiana tabacum</i>) of nine <i>AMTs</i> and four <i>NRTs</i>, which are respectively divided into four (<i>AMT1/2/3/4</i>) and two (<i>NRT1/2</i>) clusters and whose functionalities were preliminarily evidenced by heterologous functional-complementation in yeast or Arabidopsis. Tissue-specific transcriptional profiling by qPCR revealed that <i>NtAMT1.1</i>/<i>NRT1.1</i> mRNA occurred widely in leaves, flower organs and roots; only <i>NtAMT1.1/1.3/2.1NRT1.2/2.2</i> were strongly transcribed in the aged leaves, implying their dominant roles in N-remobilization from source/senescent tissues. N-dependent expression analysis showed a marked upregulation of <i>NtAMT1.1</i> in the roots by N-starvation and resupply with N including [Formula: see text], suggesting a predominant action of NtAMT1.1 in [Formula: see text] uptake/transport whenever required. The obvious leaf-expression of other <i>NtAMTs</i> e.g., <i>AMT1.2</i> responsive to N indicates a major place, where they may play transport roles associated with plant N-status and ([Formula: see text]-)N movement within aerial-parts. The preferentially root-specific transcription of <i>NtNRT1.1/1.2/2.1</i> responsive to N argues their importance for root [Formula: see text] uptake and even sensing in root systems. Moreover, of all <i>NtAMT</i>s/<i>NRTs</i>, only <i>NtAMT1.1</i>/<i>NRT1.1/1.2</i> showed their root-expression alteration in a typical diurnal-oscillation pattern, reflecting likely their significant roles in root N-acquisition regulated by internal N-demand influenced by diurnal-dependent assimilation and translocation of carbohydrates from shoots. This suggestion could be supported at least in part by sucrose- and MSX-affected transcriptional-regulation of <i>NtNRT1.1/1.2</i>. Thus, present data provide valuable molecular bases for the existence of <i>AMTs/NRT</i>s in tobacco, promoting a deeper understanding of their biological functions.
Power cycle tests of high temperature Ag sinter die-attach on metalized ceramic substrate by using micro-heater SiC chip (2018)

Abstract Next generation power semiconductors, e.g. SiC and GaN, are emerging for the further minimization and high current/voltage of power devices with high reliability covering wider operating environments than those based on Si. To implement high reliability operation, the key technology is the control of the temperature distribution in the module, and thermal stress caused by the heat generated by power loss. In the present study, we have developed SiC micro-heater chip with temperature probe to evaluate thermal characteristics of an assembled system of Ag sinter die-attach on metalized ceramic substrate (Cu/Si3N4/Cu) during the repetitive power cycling. The test specimens were fixed on a water cooling system, and steady-state heat resistance of the system was measured during the power cycling. For comparison, Pb-Sn, Sn-Cu-Ni-P, Sn-Ag-Sb-Cu solders were used as die-attach material bonded on the same metalized ceramic substrates. The maximum applied power exceeds 200 W with cycles of 2 seconds of heating and 5 seconds of cooling, and the test cycles was over 5000 cycles. The power cycle number dependence on the temperature swing and thermal resistance characteristics would be discussed, in connected with the power cycle testing for real power devices.
Genome-Wide Identification, Characterization and Expression Analyses of Heat Shock Protein-Related Genes in a Highly Invasive Ascidian Ciona savignyi (2018)

Biological response to rapid changing environments is an outstanding research question in ecology and evolution. Biological invasions provide excellent "natural" experiments to study such a complex response process, as invaders often encounter rapidly changing environments during biological invasions. The regulation of heat shock proteins (Hsp) is a common pathway responsible for various environmental stresses; however, the comprehensive study on Hsp system across the whole genome and potential roles in determining invasion success are still largely unexplored. Here, we used a marine invasive model ascidian, <i>Ciona savignyi</i>, to investigate transcriptional response of Hsp-related genes to harsh environments. We identified 32 genes, including three Hsp20, six Hsp40, ten Hsp60, eight Hsp70, three Hsp90, one Hsp100, and one heat shock transcription factor (Hsf), across the whole genome of <i>C. savignyi</i>. We further characterized gene structure and protein motifs, and identified potential heat shock elements (HSEs) in promoters of Hsp genes. The expression analysis showed that most Hsp genes, but not all, were involved in transcriptional response to temperature and salinity challenges in a duration- and stress-specific pattern, and the maximum amplitude of induction occurred in Hsp70-4 after 1-h of high temperature treatment. However, the Hsf gene was scarcely induced and limited interactions were predicted between Hsp and Hsf genes. Our study provide the first systematic genome-wide analysis of Hsp and Hsf family in the marine invasive model ascidian, and our results are expected to dissect Hsp-based molecular mechanisms responsible for extreme environmental adaptation using <i>Ciona</i> as a model system.
Reducing Surfactants–Silica Interactions for High-Coverage Silane-Modification of MCM-41 and MCM-48 Silicas (2002)

Abstract Reducing surfactants-silica interactions in the acid solution provides a novel and efficient strategy for obtaining high-coverage silanes grafted MCM-41 or MCM-48 mesoporous materials and a simultaneous recovery of the surfactants under a mild modification condition.
Towards Semantic Interoperability (In-depth comparison of two approaches to solving Semantic Web Service Challenge mediation tasks) (2007)

This paper overviews and compares the DERI and DEI-Cefriel approaches to the SWS-Challenge workshop mediation scenario in terms of the utilized underlying technologies and delivered solutions. In the mediation scenario one partner uses RosettaNet to define its B2B protocol while the other one operates on a proprietary solution. Goal of the workshop participants was to show how could these partners be semantically integrated.
The Effect of Dust and Sand on the Propagating EM Millimeter Plane Wave (2022)

Different applications in our life use wireless connections to provide varying telecommunication services. These wireless channels are affected by different weather factors such as rain, snow, dust, and sand. In the past, more research was concentrated on the effect of weather factors on the millimeter plane waves especially during rainy days. The desert regions in the world are the sources of dust and sand. In this country, the south west is a source of dust and sand during windy days. Previous work investigated the effect of dust and sand on the 5G millimeter wave by calculating the path loss of the propagating length to estimate the received power at the destination point. In this research, the effect of dust and sand on the propagating electric field is investigated by determining the complex dielectric constant of dusty region to estimate the wave number and attenuation factor of the propagating plane wave. The Maxwell's equations are used to find the expression of the electric field in the form of linear, circular and elliptic polarization. Moreover, this work will investigate the behaviour of propagating waves through dusty/sandy region with different polarization. The numerical result displays the best polarization that is recommended to use during dusty/sandy weather. Also, the penetration of the millimeter wave in the dusty lossy medium is different with different values of humidity. In this research, MATLAB is used to simulate the effect of dust and sand on the propagating electromagnetic millimeter wave.
Self-organized growth of metallic nanoparticles under homogeneous light excitation (2014)

International audience
On the importance of recrystallization to reproduce the Taylor impact specimen shape of a pure nickel (2015)

Taylor tests are a mean to investigate the dynamic plastic and failure behaviour of metals under compression. By taking in account the strengthening occurring at high strain rates, the Taylor final diameter of a pure nickel impacted at 453 m/s have been numerically reproduced by 13%. Through post-mortem observations of the specimen impacted at 453 m/s, a recrystallization process has been found to occur resulting in a softening of the pure nickel. Subsequent numerical simulations taking in account this softening have been found to reduce the difference between experimental and numerical diameter by 10%.
Measurements of the emission spectra of LiF during thermoluminescence (1983)

Abstract Studies of the emission spectra during thermoluminescence were analysed for various specimens of LiF:Ti and LiF:Mg;Ti. These suggest that the luminescence centre is a defect complex of Ti modified, in the Mg doped crystals, by Mg in various forms. The dependence of the TL peaks on dose and LET support the suggestion that the higher temperature peaks are complexes which trap more than one charge. Red emission is observed in Mg doped crystals.
Synthesis of Polyolefins with Combined Single‐Site Catalysts (2012)

Abstract This manuscript shows how two single‐site catalysts can be used to produce polyolefins with complex microstructures that cannot be made using conventional Ziegler‐Natta or Phillips catalysts. In the first case study, thermoplastic polyolefins with heterogeneously branched structures are made by the copolymerization of ethylene, an α‐olefin, and an α‐ω diene using two metallocene catalysts in a two‐stage solution polymerization process. In the second, metallocenes and late transition metal catalysts are co‐supported on silica particles to produce ethylene/α‐olefin copolymers with inverse comonomer distribution in a single slurry reactor, by manipulating the comonomer reactivity ratios and chain walking frequencies of the catalyst pair.
Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944) (2021)

NCT03568942 . Registered 26 June 2018.