gebhart/patrepeval huggingface dataset:
A Two-Phase Flowback Type-Curve for Multiscale Fluid Transport in Hydraulically Fractured Shale Reservoirs (2022)

Abstract The quantitative understanding of HF properties guides accurate production forecasts and reserve estimation. Type curve is a powerful technique to characterize hydraulic fracture (HF) and reservoir properties from flowback and long-term production data. However, the two-phase flow of water and hydrocarbon after an HF stimulation together with the complex transport mechanisms in shale nanopores exacerbate the nonlinearity of the transport equation, causing errors in type-curve analysis. Accordingly, we propose a new two-phase type-curve method to estimate HF properties, such as HF volume and permeability of fracture, through the analysis of flowback data of multi-fractured shale wells. The proposed type curve is based on a semianalytical solution that couples the two-phase flow from the matrix with the flow in HF by incorporating matrix influx, slippage effect, stress dependence, and the spatial variation of fluid properties in inorganic and organic pores. For the first time, multiple fluid transport mechanisms are considered into two-phase type-curve analysis for shale reservoirs. We analyze the flowback data from a multi-fractured horizontal well in a shale gas reservoir to verify the field application of the proposed method. The results show that the fracture properties calculated by the type-curve method are in good agreement with the long-time production data.
Abstract P6-13-21: Phase 1 study of GR antagonist mifepristone (M) in combination with eribulin (E) in advanced solid tumors, with dose expansion in patients (pts) with GR-positive triple-negative breast cancer (TNBC) (2016)

Abstract Background: High tumor GR expression is associated with poor prognosis in estrogen receptor (ER) negative early-stage breast cancer. Co-treatment with M, a GR antagonist, potentiates effects of chemotherapy in ER- breast cancer xenograft studies. Herein we describe results of a phase 1 dose-escalation study of M plus E, with an ongoing dose expansion cohort in pts with GR+ TNBC. Objectives: Determine 1) safety and tolerability, 2) recommended phase 2 dose (RP2D) of M + E, and 3) characterize pharmacokinetics (PK) and clinical activity of M in pts with GR+ TNBC. Methods: Eligibility: 1) relapsed/refractory breast, ovarian, prostate, urothelial, sarcoma, or non-small cell lung cancer; 2) 2-5 prior chemotherapy regimens for advanced disease; 3) ECOG PS 0-1; and 4) adequate end-organ function. Study used a 3 + 3 dose escalation scheme. After a 7 day lead-in of M alone, M was administered by mouth daily in combination with E given IV on days 1 and 8 of a 21 day cycle. Results: 13 pts in Part 1 Dose escalation with metastatic breast cancer (MBC) were treated with M+E: 5 TNBC, 8 GR+ tumors, 2 GR- tumors, and 3 of unknown GR status. Pts were treated at 3 dose levels (DL)[M mg/d, E mg/m2]: 3 at DL1 [600, 1.1] 4 at DL-1a [300, 1.4], and 6 at DL-1 [300, 1.1]. Median duration of treatment was 90+ days. Neutropenia leading to delay of E was dose limiting in 4 pts. CTAE Grade 3/4 neutropenia was observed in 10 pts over all DL, but easily managed (9 pts with growth factor support). Other grade 3+ toxicities were neuropathy (2 pts) and onycholysis (1 pt). No other significant toxicity was noted. RP2D was determined as 300mg/d M and 1.1mg/m2 E. At this DL there were no DLTs. PK of M and E were as predicted from published literature with no evidence of drug-drug interaction (DDI). A total of 6 pts received this dose (3 TNBC; 3 MBC). All 3 TNBC were GR+. 1 had partial response, 1 had stable disease, and 1 had progressive disease. A phase I/II study of M+E is now in progress. To date, 3 GR+ TNBC pts have been treated for a median of 28+ days. Conclusion: M + E is a novel combination designed to improve antitumor activity. It is well tolerated with evidence of clinical activity and no evidence of DDI. RP2D is 300mg M + E 1.1mg/m2. Study is ongoing in expansion phase where recruitment is limited to pts with GR+ TNBC. Additional PK and clinical data will be presented. Citation Format: Wilks S, Modiano M, Spira A, Becerra C, Walling J, Nguyen D, Baker G, Conzen SD, Nanda R. Phase 1 study of GR antagonist mifepristone (M) in combination with eribulin (E) in advanced solid tumors, with dose expansion in patients (pts) with GR-positive triple-negative breast cancer (TNBC). [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-13-21.
Electron nuclear double resonance (ENDOR) of bis(imidazole) ligated low-spin ferric heme systems (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron nuclear double resonance (ENDOR) of bis(imidazole) ligated low-spin ferric heme systemsCharles P. Scholes, Krzystof M. Falkowski, Shirley. Chen, and Janet. BankCite this: J. Am. Chem. Soc. 1986, 108, 7, 1660–1671Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ja00267a041https://doi.org/10.1021/ja00267a041research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanosecond two-photon absorption and lasing in fluorene-based organic semiconductors (2012)

This work reports the nanosecond nonlinear absorption properties of two fluorene-based organic semiconductors and their application in nanosecond two-photon pumped lasers. The materials studied under nanosecond excitation are a first generation bisfluorene-cored dendrimer with biphenyl dendrons, and 2-ethylhexyloxy surface groups and poly(9,9-di-n-octylfluorene). The nonlinear absorption properties are reported, together with tunable distributed feedback lasers that operate under nanosecond two-photon excitation at 600 nm for the dendrimer and 650 nm for the polymer. This highlights the feasibility of optically pumping organic lasers using long excitation pulses in the red part of the spectrum.
Islet Transplantation and Encapsulation: An Update on Recent Developments (2011)

Human islet transplantation can provide good glycemic control in diabetic recipients without exogenous insulin. However, a major factor limiting its application is the recipient's need to adhere to life-long immunosuppression, something that has serious side effects. Microencapsulating human islets is a strategy that should prevent rejection of the grafted tissue without the need for anti-rejection drugs. Despite promising studies in various animal models, the encapsulated human islets so far have not made an impact in the clinical setting. Many non-immunological and immunological factors such as biocompatibility, reduced immunoprotection, hypoxia, pericapsular fibrotic overgrowth, effects of the encapsulation process and post-transplant inflammation hamper the successful application of this promising technology. In this review, strategies are discussed to overcome the above-mentioned factors and to enhance the survival and function of encapsulated insulin-producing cells, whether in islets or surrogate β-cells. Studies at our center show that barium alginate microcapsules are biocompatible in rodents, but not in humans, raising concerns over the use of rodents to predict outcomes. Studies at our center also show that the encapsulation process had little or no effect on the cellular transcriptome of human islets and on their ability to function either in vitro or in vivo. New approaches incorporating further modifications to the microcapsule surface to prevent fibrotic overgrowth are vital, if encapsulated human islets or β-cell surrogates are to become a viable therapy option for type 1 diabetes in humans.
Optical fibre transducers (1982)

Light travelling in an optical fibre may be directly modulated by external parameters such as pressure, strain, temperature, etc. Thus the fibre may form the basis of a transducer involving neither moving parts nor electrical connections. Another class of transducers uses the fibre as a means of guiding light from a monitoring point to the measuring point where the light is externally modulated. This paper presents a review of the current status of optical fibre sensors and discusses their future potential.
Brain-Derived Neurotrophic Factor (BDNF) Is Associated with Platelet Activity and Bleeding Tendency in Patients with Gaucher Disease (2022)

Bleeding tendency, a prominent feature of patients with Gaucher disease (GD), is associated with abnormal platelet function. Brain-derived neurotrophic factor (BDNF) is a protein with neuroprotective potential stored in alpha granules of circulating platelets. Here we studied BDNF levels in 50 patients with type I GD (GD1) and their correlation with platelet activity and bleeding tendency. Flow cytometry was used to test unstimulated and stimulated measurement of platelet surface-activated expression of αIIbβ3 integrin, P-selectin and lysosomal-associated membrane protein (LAMP3/CD63). Serum and plasma BDNF levels were quantified using ELISA. The bleeding history was recorded by a bleeding questionnaire. Serum BDNF levels were positively correlated with platelet count and moderately correlated with unstimulated and stimulated platelet P-selectin expression. Patients with more than one bleeding manifestation were shown to have lower serum BDNF levels, albeit similar platelet count. Plasma BDNF levels were significantly elevated in splenectomized patients and showed a moderate positive correlation with stimulated platelet CD63 expression. These observations demonstrate the first association between BDNF levels in the peripheral blood with platelet dysfunction and increased bleeding manifestation. The role of measuring serum BDNF for assessing platelet alpha degranulation defects and bleeding risk in patients with GD and the general population needs further study.
Variações da cor preta e negra na pintura de Eduardo Sued (2009)

Eduardo Sued transforma o pigmento preto de sua paleta física em campos cromáticos em suas pinturas. Ele costuma diferenciar a cor preta da cor negra. Diz que o preto torna-se negro à medida que a escuridão e a intensidade vão se apossando dele. Para Sued, o preto permite o passeio apenas em sua superfície, enquanto no negro há profundidade. "Há noites pretas e noites negras!" Nesta entrevista, Sued discorre sobre o que fomenta sua produção pictórica, em especial o uso que faz da tinta preta para criar seus pretos e seus negros.<br>Eduardo Sued transforms the black pigment of his physical palette in color fields on his paintings. He usually distinguishes black from "darkblack". He says black goes to "dark black" as darkness and intensity take hold of it. For him, the black works only on its surface, while "darkblack" is deep. "There are black nights and 'darkblack' nights!" In this interview Sued talks about what promotes his pictorial production, in particular his use of black paint to create his black and darkblack fields.
New Synthesis of the Both Enantiomers of (Z)-5-(1-Decenyl)-oxacyclopentan-2-one, the Pheromone of the Japanese Beetle (1979)

The both enantiomers of (Z)-5-(1-decenyl)oxacyclopentan-2-one were synthesized starting from resolved acetylenic intermediates. The (R)-form of this lactone is the pheromone of Popillia japonica. The optical purities of the final products were about 90%.
Weighted Multi-Path Procedures for EVPN Multi-Homing (2000)

EVPN enables all-active multi-homing for a CE device connected to two
or more PEs via a LAG, such that bridged and routed traffic from
remote PEs to hosts attached to the Ethernet Segment can be equally
load balanced (it uses Equal Cost Multi Path) across the multi-homing
PEs. EVPN also enables multi-homing for IP subnets advertised in IP
Prefix routes, so that routed traffic from remote PEs to those IP
subnets can be load balanced. This document defines extensions to EVPN
procedures to optimally handle unequal access bandwidth distribution
across a set of multi-homing PEs in order to: o provide greater
flexibility, with respect to adding or removing individual multi-homed
PE-CE links. o handle multi-homed PE-CE link failures that can result
in unequal PE-CE access bandwidth across a set of multi-homing PEs.
Bit Serial Multiplication in Finite Fields (1990)

Bit serial multiplication schemes for hardware implementation of arithmetic in a finite field of characteristic two are considered. In addition, certain aspects of polynomial bases in finite fields are investigated.
Evaluation of Oral Immunization with Recombinant Avian Influenza Virus HA1 Displayed on the Lactococcus lactis Surface and Combined with the Mucosal Adjuvant Cholera Toxin Subunit B (2011)

The development of safe and efficient avian influenza vaccines for human and animal uses is essential for preventing virulent outbreaks and pandemics worldwide. In this study, we constructed a recombinant (pgsA-HA1 gene fusion) Lactococcus lactis strain that expresses and displays the avian influenza virus HA1 antigens on its surface. The vectors were administered by oral delivery with or without the addition of cholera toxin subunit B (CTB). The resulting immune responses were analyzed, and the mice were eventually challenged with lethal doses of H5N1 viruses. Significant titers of hemagglutinin (HA)-specific serum IgG and fecal IgA were detected in the group that also received CTB. Cellular immunities were also shown in both cell proliferation and gamma interferon (IFN-γ) enzyme-linked immunospot (ELISpot) assays. Most importantly, the mice that received the L. lactis pgsA-HA1 strain combined with CTB were completely protected from lethal challenge of the H5N1 virus. These findings support the further development of L. lactis-based avian influenza virus vaccines for human and animal uses.
Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension (2005)

Pulmonary hypertension (PH) is characterised by progressive elevation of pulmonary artery pressure and pulmonary vascular resistance. Pathohistological findings have demonstrated that PH is associated with abnormal vascular structures, including medial and/or intimal hypertrophy, concentric or eccentric intimal fibrosis, obstruction in the arterial lumen, and aneurysmal dilatation.1 Patients with PH are currently treated with anticoagulant agents, vasodilators including continuous intravenous prostacyclin (prostaglandin I2) and oral sildenafil or bosentan, and in end stage, with lung transplantation,1 when applicable. Endothelial dysfunction of pulmonary arteries and enhanced pulmonary vasoconstriction contribute to the development of PH.1 Endothelial nitric oxide synthase (eNOS) expression is reduced in patients with PH and therefore nitric oxide inhalation and sildenafil are useful for those patients. However, more effective treatments remain to be developed.1

We have recently demonstrated that Rho-kinase is substantially involved in the pathogenesis of a wide range of cardiovascular disease.2,3 Rho-kinase suppresses myosin phosphatase activity by phosphorylating the myosin binding …
Immune Reconstitution Analysis of Patients Undergoing Extracorporeal Photopheresis for the Treatment of Chronic Graft-Versus-Host Disease (2015)

Allogeneic blood and marrow transplantation for the treatment of hematologic malignancies continues to be plagued by complications such as chronic graft-versus-host disease (cGVHD), which can occur in upwards of 50% of patients. Standard therapy involves corticosteroid administration, which is not always effective and impedes the patient's return to a completely competent immune system, thus increasing the risk of infectious complications. Extracorporeal photopheresis (ECP) has been successfully used to abate cGVHD symptoms in many patients. The effect this therapy has on lymphocyte subsets in the reconstituting immune compartment has yet to be fully ascertained. In the present study, we used flow cytometric analysis to examine lymphocyte subsets in patients undergoing ECP for the treatment of cGVHD. Peripheral blood was collected from 5 patients prior to starting ECP and after 90 days of treatment. CD4+T cell populations were analyzed for expression of CD45RA and CCR7 to classify naïve (RA+, CCR7+), central memory (TCM; RA-, CCR7+), effector memory (TEM; RA-, CCR7-), and terminally differentiated effector memory (TEMRA; RA+, CCR7-) T cells. The data reported supports previous studies which show that all CD4+ T cell populations analyzed are altered in cGVHD patients (n=11) compared to healthy controls (n=5). In particular, CD4+ TCM and naïve cells were decreased in cGVHD patients, while CD4+ TEM and TEMRA were elevated in these patients. Analysis of the same subsets in cGVHD patients after 90 days of ECP treatment revealed that the percentage of CD4+ TCMincreased above baseline levels in the 5 cGVHD patients examined, while CD4+ TEMRA were decreased during the same time frame. The increase in CD4+ TCM and the decrease in CD4+ TEMRA were statistically significant as determined by the paired Student's t test. Additionally, the ratio of CD4+ TCM to TEM and CD4+ TCM to TEMRA was calculated in patients before and after ECP treatment. Results indicate significantly increased ratios of both TCM:TEMand CD4+ TCM:TEMRA in these patients as well. This data strongly supports the role of ECP in the normalization of CD4+ T cell populations in cGVHD patients.
Blockchain Technology as a Means for Brand Trust Repair – Empirical Evidence from a Digital Transgression (2020)

Though much discussion in the realm of blockchain revolves around the concept of trust, research examining blockchain technology as a means for brand trust repair is still at an initial stage. This study conducts an experiment that analyzes blockchain technology as a substantive response to a data breach within a global business-to-consumer information systems application. Thereby, the present study expands trust repair theories to the context of blockchain and branding. Research results indicate that the use of blockchain technology as a reaction to a digital transgression may be able to reinstate brand trust, having a superior impact compared to an approach that uses a centrally managed information systems platform to restore brand trust. Overall, study results suggest that the use of blockchain technology can be an effective component of brand trust repair strategies in the digital space.
Research on the Critical Nodes Compensation Algorithm in Sparse Ad Hoc Wireless Networks (2009)

Sparse Ad hoc wireless networks are an active application in recent years, though sparse environment often makes the network unconnected. However, most of the previous researches focus on connected networks where an end-to-end path exists between any two nodes in the network, therefore these technologies would not work well in sparse ad hoc networks where restricted node communication radius can result in periods of intermittent connectivity. In this work, we develop a critical nodes compensation algorithm in order to prevent network from partitioning, thereby insure network connectivity and throughput. Finally, we give simulation design and analysis of the critical nodes compensation algorithm using NS model. Simulation results show that the algorithm can effectively improve sparse ad hoc networks performance.
Postharvest dip in a natural lipid, lysophosphatidylethanolamine, may prolong vase life of snapdragon flowers (1997)

We investigated the use of lysophosphatidylethanolamine (LPE) for prolonging vase life of snapdragon (Antirrhinum majus L.). Freshly cut snapdragon spikes were set into a LPE solution at 25 mg.L -1 for 24 h and then transferred to deionized water. The vase life was enhanced by LPE. The flowers on spikes treated with LPE showed symptoms of wilting or browning 4 or 6 days later than those on the spikes given deionized water in inbred or 'Potomac White', respectively. All the spikes were of marketable quality for 5 to 7 days after harvest when treated with LPE, whereas in the control only about half of the flowers were of marketable quality at 2 days after harvest. LPE treatment also delayed fresh mass loss, lowered endogenous ethylene production, and reduced ion leakage. These results suggest that LPE has commercial potential in enhancing vase life of snapdragons.
Voided Urine Flow Cytometry in Screening High-Risk Patients for the Presence of Bladder Cancer (1990)

Fifty-nine patients with a history of bladder cancer were evaluated with three serially voided urines for flow cytometry and cytology within the 24 hours preceding cystoscopy, bladder wash, and biopsy. Evaluation of the 32 patients with biopsy proven cancer revealed that for one, two, and three voided urine specimens, the sensitivity of flow cytometry in detecting bladder cancer was 29%, 35%, and 41%, respectively, whereas the sensitivity of voided urine cytology was 44%, 53%, and 57%, respectively. Bladder wash flow cytometry had a sensitivity of 76%. Interpretation of the voided urine flow cytometry was based on a control group of 80 volunteers with negative voided urine cytology. The control group demonstrated that a minimum of 1500 analyzable cells was necessary for a reliable histogram. Considering all 59 patients, voided urine flow cytometry, bladder wash flow cytometry, and voided urine cytology were acceptable for analysis in 53%, 93%, and 100% of the specimens, respectively. Voided urine specimens appear less suitable than bladder irrigation specimens for evaluation by flow cytometry. Voided urine flow cytometry is less sensitive in detecting bladder cancer than voided urinary cytology or bladder wash flow cytometry and is not effective for use as a bladder cancer screening test.
Innovation, Technology and Decision Making: A Perspective for Strategic Action in Firms (2002)

Innovation, technology, and the making of decisions are tightly intertwined in what can generally be called, strategic decision making. Although true for all firms, it is especially true in innovative, high technology firms that operate in a turbulent, fast moving environment where strategic decisions must be made accurately and quickly to survive. This paper looks at some factors reported in the literature that affect how and why the strategic decision process is so important, especially in companies in fast-moving, competitive environments. The work of several prominent authors who looked critically at past theory and research, and the current state of knowledge and practice, provides a perspective of how firms make strategic decisions.
Enabling Ideal Selective Solar Absorption with 2D Metallic Dielectric Photonic Crystals (2014)

A metallic dielectric photonic crystal with solar broadband, omni-directional, and tunable selective absorption with high temperature stable (1000 °C, 24 hrs) properties is fabricated on a 6" silicon wafer. The broadband absorption is due to a high density of optical cavity modes overlapped with an anti-reflection coating. Results allow for large-scale, low cost, and efficient solar-thermal energy conversion.