gebhart/patrepeval huggingface dataset:
A phase 2 study of simtuzumab in patients with primary, post‐polycythaemia vera or post‐essential thrombocythaemia myelofibrosis (2017)

Simtuzumab, a monoclonal antibody inhibitor of extracellular matrix enzyme lysyl oxidase-like-2, showed preclinical promise and was well tolerated in clinical studies. A phase 2, open-label study of simtuzumab was conducted in patients with primary myelofibrosis (MF), post-polycythaemia vera MF and post-essential thrombocythaemia MF. Fifty-four patients were randomized to receive simtuzumab alone (200 or 700 mg [n = 12 each group]) or simtuzumab (200 or 700 mg) with ruxolitinib (n = 15 each group) for 24 weeks. Simtuzumab alone or in combination with ruxolitinib showed no clinical benefit at 24 weeks. The mean serum simtuzumab trough concentrations appeared to increase dose-proportionally between the 200-mg and 700-mg treatment groups. Therapy-related serious adverse events were pyrexia, pain in extremity (both in 1 patient) and infusion reaction (in another patient). Bone marrow fibrosis (BMF) score was reduced at 24 weeks in 2 patients (16·7%) in the simtuzumab 700-mg group, 1 (6·7%) in the simtuzumab 200-mg + ruxolitinib group, and 2 (13·3%) in the simtuzumab 700-mg + ruxolitinib group; similar numbers of patients had increased BMF. Simtuzumab alone or with ruxolitinib was well tolerated but did not produce clinical benefit nor consistently reduce BMF in patients with MF by 24 weeks.
Self-Assembly of a Zinc Bacteriochlorophyll-d Analog with a Lipophilic Tertiary Amide Group in the 17-Substituent (2022)

Abstract Self-assembled aggregates of bacteriochlorophyll(BChl)-c/d/e pigments play key roles in major light-harvesting antenna systems of photosynthetic green bacteria. Herein, we report the self-assembly of a lipophilic zinc BChl-d model with an N,N-didodecylamide in the 17-substituent. The present model formed two types of J-aggregates, which formed under kinetic and thermodynamic controls.
Sclerotherapy for gastric fundal variceal bleeding: Is complete obliteration possible without cyanoacrylate? (2005)

The sclerotherapy method carried out using 5% ethanolamine oleate combined with infusion of vasopressin under fluoroscopic guidance might be a feasible method for obliteration of gastric fundal varices as an alternative to cyanoacrylate.
Study on microstructure and mechanical properties of polydiacetylene composite biosensors (2019)

ABSTRACT 10,12‐Pentacosadiynoic acid (PCDA) monomers were mixed with polyurethane (PU) or poly(ethylene oxide) (PEO) and the mixtures were electrospun to obtain composite nanofibers that were then photopolymerized via ultraviolet radiation, resulting polydiacetylene (PDA) in the nanofibers. The PDA demonstrated color‐changing properties in the presence of Escherichia coli , which exhibited potential for developing flexible colorimetric biosensors for medical textiles. Phase separation was found in the PEO–PDA fibers, resulting in amorphous PEO accumulation at the fiber surface. In contrast, the PU–PDA fibers demonstrated a homogeneous microstructure throughout the fibers. Tensile test results suggested a molecular orientation in the PU–PDA fibers that significantly improved the mechanical properties of the fibers. The presence of PDA in the matrix polymer reduced the overall strength and breaking elongation of both composite nanofibers in comparison to 100% PEO and PU fibers. A single PU–PDA fiber showed significantly higher stiffness and modulus than a single PEO–PDA fiber. Force–distance curve analysis suggested that the PU–PDA fibers exhibited an elastic deformation. In a comparison, the PEO–PDA fibers were brittle and showed low modulus. The results of structural and mechanical properties suggest that the PU–PDA nanofibers are a promising composite for developing nonadherent, durable, and flexible colorimetric biosensors used in medical textiles. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47877.
Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice (2020)

NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in GRIN2A encoding the GluN2A subunit are associated with a spectrum of disorders, ranging from mild speech and language delay to intractable neurodevelopmental disorders, including but not limited to developmental and epileptic encephalopathy. A de novo missense variant, p.Ser644Gly, was identified in a child with this disorder, and Grin2a knock-in mice were generated to model and extend understanding of this intractable childhood disease. Homozygous and heterozygous mutant mice exhibited altered hippocampal morphology at 2 weeks of age, and all homozygotes exhibited lethal tonic-clonic seizures by mid-third week. Heterozygous adults displayed susceptibility to induced generalized seizures, hyperactivity, repetitive and reduced anxiety behaviours, plus several unexpected features, including significant resistance to electrically-induced limbic seizures and to pentylenetetrazole induced tonic-clonic seizures. Multielectrode recordings of neuronal networks revealed hyperexcitability and altered bursting and synchronicity. In heterologous cells, mutant receptors had enhanced NMDA receptor agonist potency and slow deactivation following rapid removal of glutamate, as occurs at synapses. NMDA receptor-mediated synaptic currents in heterozygous hippocampal slices also showed a prolonged deactivation time course. Standard anti-epileptic drug monotherapy was ineffective in the patient. Introduction of NMDA receptor antagonists was correlated with a decrease in seizure burden. Chronic treatment of homozygous mouse pups with NMDA receptor antagonists significantly delayed the onset of lethal seizures but did not prevent them. These studies illustrate the power of using multiple experimental modalities to model and test therapies for severe neurodevelopmental disorders, while revealing significant biological complexities associated with GRIN2A developmental and epileptic encephalopathy.
A portable high-frequency digitally controlled oscillator (DCO) (2013)

A novel digitally-controlled oscillator (DCO) is reported. Utilizing a new capacitive load, the new DCO is capable of producing much higher output frequencies than existing DCOs. All other components are fully digital and modular, allowing portability to any CMOS process and customization for different applications. At the heart of the DCO is a digital ring oscillator (DRO) that utilizes the new shunt-capacitive loads. Unprecedented higher frequencies are obtained through a novel idea of electrically removing the effect of un-enabled loads. Simple design conditions for achieving proper operation of the DRO are provided. Spice simulations verified the correct and superior operation of the DCO even with device mismatch. A custom layout of the DRO was generated using LFoundry's 150 nm technology. The total DRO area was found to be 418 μm2.
Human umbilical cord blood cells form epidermis in the skin equivalent model (2010)

Recently, human embryonic stem cells have been differentiated in vitro into functional epidermal keratinocytes. Here, we demonstrated that these cells can be generated also from non-embryonic, human umbilical cord blood (hUCB) cells that have the potential to differentiate into cells of non-hematopoietic lineage. Human UCB mono-nucleated cells were cultivated in monolayer and in three-dimensional skin equivalent cultures and assayed for the presence of phenotype-specific markers. Our results determined that after one month of culturing in serum containing medium, the hUCB cells produced morphologically homogeneous colonies of epithelial cells expressing keratinocyte-specific markers. They also formed stratified epidermis in organ cultures that contained sporadic CD1a-positive cells within the accurate strata. We concluded that hUCB cells have the capacity to differentiate into functional epidermal keratinocytes and may serve as a source of high-quality keratinocytes for clinical applications.
Pan‐Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells (2011)

Kleine Moleküle erledigen den Job: Somatische Zellen werden durch ektopische Expression von Oct4, Sox2, Klf4 und c-Myc in iPS-Zellen umprogrammiert. Mithilfe eines zellbasierten Hochdurchsatz-Screenings wurden Inhibitoren der Src-Kinase (SFK) als „chemischer Ersatz“ für den retroviralen Sox2-Transport identifiziert. Diese Verbindungen werden genutzt, um die Mechanismen der direkten Umprogrammierung zu untersuchen, und sie könnten letztlich dazu beitragen, die klinische Anwendung von iPS-Zellen einen Schritt näher zu bringen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Chemistry of crystalline aluminosilicates. VI. Preparation and properties of ultrastable hydrogen zeolite Y (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of crystalline aluminosilicates. VI. Preparation and properties of ultrastable hydrogen zeolite YGeorge T. KerrCite this: J. Phys. Chem. 1969, 73, 8, 2780–2782Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/j100842a056https://doi.org/10.1021/j100842a056research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Integration of water reuse in the planning of livable cities (2011)

Until recently, urban water management was preferentially focused on treating water for safe use by human beings, and treating wastewater for safe discharge into natural water bodies. Because water availability in the rapidly growing cities is very often extremely limited, a shift of focus towards recovery and reuse concepts appears to be inevitable. Representatives of water authorities, spatial and urban planners, architects, utility managers and the civil society are urged to realize that wastewater is a resource rather than a liquid to be wasted. After proper treatment, the wastewater is to be considered as an alternative source of usable water. It might be utilized for groundwater recharge, for irrigation of parks and gardens, for toilet flushing and even for direct human consumption. Centralized water reuse strategies have already been introduced in cities such as Singapore but need to be complemented by decentralized solutions down to the level of housing complexes, high-rise buildings, hotels and r...
Advanced Technologies for Design Information Verification (2009)

This paper discusses several technologies that have the potential to enhance facilities design verification. These approaches have shown promise in addressing the challenges associated with the verification of sub-component geometry and material composition for structures that are not directly accessible for physical inspection. A simple example is a pipe that extends into or through a wall or foundation. Both advanced electromagnetic and acoustic modalities will be discussed. These include advanced radar imaging, transient thermographic imaging, and guided acoustic wave imaging. Examples of current applications are provided. The basic principles and mechanisms of these inspection techniques are presented along with the salient practical features, advantages, and disadvantages of each technique. Other important considerations, such as component geometries, materials, and degree of access are also treated. The importance of, and strategies for, developing valid inspection models are also discussed. Beyond these basic technology adaptation and evaluation issues, important user interface considerations are outlined, along with approaches to quantify the overall performance reliability of the various inspection methods.
Thermoforming shrinkage prediction (2001)

Abstract Most thermoforming product development processes rely on costly and time‐consuming forming trials to determine the adequacy of the mold and process. In this paper, an analytical method is developed for shrinkage predictions on the basis of a visco‐elastic constitutive material model with initial conditions from a commercial thermoforming simulation. The theoretical analysis has been developed to accommodate different sets of materials, process conditions, and mold geometry. The shrinkage model consists of a transient thermal analysis for temperature solution; a stretching phase analysis for Inflation‐induced stress estimation; a post‐contact analysis for thermal stress and relaxation; and a post‐molding strain analysis based on stress solution. The shrinkage prediction analysis has been developed and validated with a complex geometry thermoforming application. The results indicate that the shrinkage estimates provided by the analysis were within the objective tolerances of 0.1%, as measured in terms of absolute prediction error of part dimensions.
Iterative Design Process for Robots With Personality (2009)

All in-text\treferences\tunderlined\tin\tblue\tare\tlinked\tto\tpublications\ton\tResearchGate, letting you\taccess\tand\tread\tthem\timmediately.
Supplemental Figure 1 from BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume (2023)

&lt;p&gt;Supplemental Figure 1. Characterization of drug response&lt;/p&gt;
Life is sweet for student chocolatiers (2011)

Last summer was a busy one for the students and dedicated&#13;\ndesign and technology staff at Worden Sports College who&#13;\nwere involved in the schools first ever Summer Technology&#13;\nAcademy.Organised and delivered by the design and technology department this was by no means a new venture for some of the team. Keith Burroughs (Head of Faculty) and Scott Cunningham (Teacher of Resistant Materials) had both been involved every year since 2005 in the schools summer academies project with Suzie Carr (Teacher of Food Technology/Catering and newly appointed Head of PHSE) involved since 2007. Previously the event had been staged by the PE department and as such had a very different focus. Having been approached to co-ordinate the event Suzie and Scott quickly enlisted the help of Keith Burroughs, Art teacher Chris Hull and several trainee teachers from Edge Hill University. Trainees from both the Flexible PGCE and BSc (Hons) in Design and Technology courses supported staff for the duration of the project
Motion estimation from tagged MR image sequences (1992)

A method for reconstructing motion from sequences of tagged magnetic resonance (MR) images is presented. MR tagging is used to create a spatial pattern of varying magnetization so that objects which may otherwise have constant intensity are textured, which reduces the motion ambiguity associated with the aperture problem in computer vision. To compensate for the decay of the tag pattern, a new optical flow algorithm is developed and implemented. The resulting estimated velocity field is then used to recursively update the implied motion reference map over time, thereby tracking the motion of individual particles. If a segmentation of the object is known at the time the tag pattern is created, then an object may be selectively tracked, using the estimated reference map to update the object's position as time progresses. Results are shown for both simulated and actual MR phantom data.
Colloid-bound and dissolved phosphorus species in topsoil water extracts along a grassland (2016)

Abstract. Stagnant water conditions may release phosphorus (P) in soil solution that was formerly bound to Fe oxides. To understand which P species are potentially involved, we obtained water extracts from the surface soils of a gradient from Cambisol, Stagnic Cambisol to Stagnosol from temperate grassland, Germany. These were filtered to Stagnosol. Across all soil types, elevated proportions of inositol hexakisphosphate species (e.g. myo-, scyllo-, and D-chiro-IHP) were associated with soil mineral particles (i.e. bulk soil and small-sized soil colloids) whereas other orthophosphate monoesters and phosphonates were found in the ‘dissolved’ P fraction. We conclude that stagnic properties affect P speciation and availability by potentially releasing dissolved inorganic and ester-bound P forms as well as nano-sized organic matter-Fe/Al-P colloids.
Statistical Image Reconstruction Methods for Transmission Tomography (2010)

The problem of forming cross-sectional or tomographic images of the attenuation characteristics of objects arises in a variety of contexts, including medical x-ray computed tomography (CT) and nondestructive evaluation of objects in industrial inspection. In the context of emission imaging, such as positron emission tomography (PET) [1, 2], single photon emission computed tomography (SPECT) [3], and related methods used in the assay of containers of radioactive waste [4], it is useful to be able to form "attenuation maps," tomographic images of attenuation coefficients, from which one can compute attenuation correction factors for use in emission image reconstruction. One can measure the attenuating characteristics of an object by transmitting a collection of photons through the object along various paths or "rays" and observing the fraction that pass unabsorbed. From measurements collected over a large set of rays, one can reconstruct tomographic images of the object. Such image reconstruction is the subject of this chapter. In all the above applications, the number of photons one can measure in a transmission scan is limited. In medical x-ray CT, source strength, patient motion, and absorbed dose considerations limit the total x-ray exposure. Implanted objects such as pacemakers also significantly reduce transmissivity and cause severe artifacts [5]. In industrial applications, source strength limitations, combined with the very large attenuation coefficients of metallic objects, often result in a small fraction of photons passing to the detector unabsorbed. In PET and SPECT imaging, the transmission scan only determines a "nuisance" parameter of secondary interest relative to the object's emission properties, so one would like to minimize the transmission scan duration. All the above considerations lead to "low-count" transmission scans. This chapter discusses algorithms for reconstructing attenuation images from low-count transmission scans. In this context, we define low-count to mean that the mean number of photons per ray is small enough that traditional filtered-backproject on (FBP) images, or even methods based on the Gaussian approximation to the distribution of the Poisson measurements (or logarithm thereof), are inadequate. We focus the presentation in the context of PET and SPECT transmission scans, but the methods are generally applicable to all low-count transmission studies. See [6] for an excellent survey of statistical approaches for the emission reconstruction problem.
Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects (2005)

It was possible to determine a predictive equation and confirm a high degree of reliability of IOS parameters in Japanese adult subjects.
Contraception in Domestic and Wild Animal Populations Using Zona Pellucida lmmunogens (1993)

The human population presently exceeds 6 billion and is continuing to expand at a startling rate. This population increase has resulted in the depletion of Earth's resources, which are essential for human survival. An unfortunate consequence of this expansion has been the destruction of wildlife habitats. As these habitats have diminished, numerous problems have arisen, including conflicts between wildlife and human populations. The threat of extinction of many plant and animal species has already become a reality; other wildlife populations have increased due to reductions in predator populations. While the increase in the human population must ultimately be checked, there is a need for effective and humane methods to regulate certain animal populations as well. Another factor relevant to animal overpopulation is regional distribution. Widespread overpopulation of such animals as white-tailed deer in North America and rabbits in Australia has caused environmental as well as health problems for humans. In Asia and Africa, the populations of some wildlife species, such as elephants, have been dramatically reduced. Often these animals have frequently been relegated to small areas of land that do not have sufficient resources to sustain them. There is a vicinal distribution of elephants in Asia and Africa whose localized high populations threaten the destruction of their own restricted habitats. The rising domestic pet population also continues to be a problem, as more than 27 million dogs and cats are impounded annually in the United States, with more than 17 million of them being euthanized (Carter 1990). The extent of domestic pet overpopulation poses ethical as well as health-related dilemmas (Flowers 1979, Carter 1990). Countless dollars are spent each year to house and dispose of impounded animals and to combat diseases transmitted by the fleas and ticks that use the dogs and cats as hosts. As these problems continue to intensify, it is apparent that a serious need exists for effective and inexpensive methods of population control.
Effects of warming up, massage, and stretching on range of motion and muscle strength in the lower extremity (1983)

The effects of general warming up, massage, and stretching on ranges of motion (ROM) and strength of quadriceps and hamstring muscles were measured in eight male volunteers. Thigh muscle strength was not influenced by the experimental procedures. Stretching resulted in a significantly increased range of hip flexion/extension, hip abduction, knee flexion, and ankle dorsiflexion; the effect was significantly greater than that obtained by massage and warming up separately or combined. Only ankle dorsiflexion was influenced by massage or warming up, whereas stretching affected all muscle groups tested. Stretching was, therefore, superior to the other methods tested for increasing flexibility in the lower extremity.