gebhart/patrepeval huggingface dataset:
Multi-UAV Path Planning for Autonomous Missions in Mixed GNSS Coverage Scenarios (2018)

This paper presents an algorithm for multi-UAV path planning in scenarios with heterogeneous Global Navigation Satellite Systems (GNSS) coverage. In these environments, cooperative strategies can be effectively exploited when flying in GNSS-challenging conditions, e.g., natural/urban canyons, while the different UAVs can fly as independent systems in the absence of navigation issues (i.e., open sky conditions). These different flight environments are taken into account at path planning level, obtaining a distributed multi-UAV system that autonomously reconfigures itself based on mission needs. Path planning, formulated as a vehicle routing problem, aims at defining smooth and flyable polynomial trajectories, whose time of flight is estimated to guarantee coexistence of different UAVs at the same challenging area. The algorithm is tested in a simulation environment directly derived from a real-world 3D scenario, for variable number of UAVs and waypoints. Its solution and computational cost are compared with optimal planning methods. Results show that the computational burden is almost unaffected by the number of UAVs, and it is compatible with near real time implementation even for a relatively large number of waypoints. The provided solution takes full advantage from the available flight resources, reducing mission time for a given set of waypoints and for increasing UAV number.
Combat climat change with competetive photovoltaics (2009)

Photovoltaics (PV) offer a promising solution for&#13;\nCO2 emission reductions and climate change&#13;\ncombat.&#13;\nHowever, before its wide spread on the&#13;\nmarket, PV needs to find new approaches to&#13;\nmake solar cells competitive with respect to&#13;\nconventional electricity sources.
Fichte as "Jew-hater" and Prophet of the Zionists (2000)

Fichte as “Jew-hater” and Prophet of the Zionists Get access Manfred Voigts Manfred Voigts Search for other works by this author on: Oxford Academic Google Scholar The Leo Baeck Institute Year Book, Volume 45, Issue 1, January 2000, Pages 81–91, https://doi.org/10.1093/leobaeck/45.1.81 Published: 01 January 2000
Ultrabroadband beam splitter with matched group-delay dispersion (2005)

We present a general design strategy for a broadband thin-film beam splitter with matched group-delay dispersion. By taking the substrate dispersion into account in the coating design, any combination of input and output can show the same dispersion for transmission and reflection. As a specific implementation, an ultrabroadband 50:50 beam splitter from 600 to 1500 nm for femtosecond laser applications was designed, fabricated, and characterized.
Abstract 3721: MMP9 responsive molecular beacon-loaded nanovesicles for imaging and therapy for triple negative breast cancer (2018)

Abstract African American women are disproportionately affected by triple negative breast cancer (TNBC). Combination of tumor chemotherapy and imaging in an ‘all-in-one system' provides a useful multi-modal approach in the battle against metastatic breast cancer. A promising imaging technique, time gated molecular beacon probes, is a noninvasive and painless method for detection and monitoring. Molecular beacon probe-based theranostic nanoparticles is a novel concept in next-generation medicine that combines simultaneous diagnostics and therapeutics to radically change the way we diagnose, image and treat breast cancer. In this study, we formulated pH sensitive nanovesicles containing molecular beacons specific to MMP-9 for imaging tumor microenvironment along with an anticancer drug, thereby enabling visualization of the tumor together with therapy at the tumor site. This theranostic nanosystem will provide an exciting new tool for breast cancer diagnosis and therapy. Formulation of novel pH responsive nanovesicles were carried out using DMPC and DSPE-PG-8CH. Molecular beacons specific to MMP-9, along with cabazitaxel were encapsulated within the nanovesicles. Characterization of the formulated nanovesicles along with intracellular uptake studies were carried out in breast cancer cell lines. The hydrodynamic diameters of the vesicles were measured using a dynamic light scattering (DLS) instrument (Malvern Zetasizer Nano-ZS) and found to be ~65nm. The zeta potential varied between -55 to -60 mV. Validation of molecular beacon loading in liposome and its stability were done using spectroscopy. Results indicated a molecular beacon loading of ≈29 % in the liposomes and the liposomes were stable for atleast 2 weeks. Comparison of cleavage sequence with time MB and MB-loaded liposome showed that even after 72 hours, molecular beacon released from the liposomes were able to cleave MMP-9 and elicit an effect. This unique and innovative combinatorial theranostic strategy can improve the accuracy of imaging and therapy, provide better assessment of the severity of disease and even monitor the response to drug therapy. This innovative proposal of combining an imaging technique together with delivery of anticancer drug at the tumor site will enhance their clinical potential for diagnosis and therapy in metastatic breast cancer therapy. Citation Format: Amalendu P. Ranjan, Rafal Fudala, Sunil Shah, Andrew Gdowski, Piyush Kumar, Ignacy Grycznski, Zygmunt Grycznski, Jamboor K. Vishwanatha. MMP9 responsive molecular beacon-loaded nanovesicles for imaging and therapy for triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3721.
A multi-scale model for mobile and localized electroluminescence in carbon nanotube field-effect transistors (2006)

A multi-scale model is presented that captures the experimentally observed behaviour of electroluminescence (EL) in carbon nanotube field-effect transistors (CNFETs) under ambipolar bias conditions, namely variations in mobile EL intensity, localized EL at a contact, and localized EL at a charge defect. A full, quantum mechanical approach is used to describe tunnelling and thermionic emission at the contacts, and the drift-diffusion equations, with a field-dependent mobility, are used for transport in the long devices (CN length ≥10 µm). We find that contact-localized EL is only present when the height of the Schottky barrier at the ends of the CN favours the injection of one type of carrier. Charge defects on the CN surface also lead to localized EL, which is present only under certain bias conditions.
Investigation of anisotropic diffused optical waveguides in LiNbO3 (1978)

An investigation was made of the polarization and spectral characteristics of diffused optical waveguides in LiNbO3 for different angles of the propagation of light relative to the crystal axis. The experimental results are compared with the theory.
Impedance and conductivity of bovine myocardium during freezing and thawing at slow rates - implications for cardiac cryo–ablation (2019)

Increasing impedance during freezing might be a valuable marker for guiding cardiac cryo-ablation. We provide model based insights on how decreasing temperature below the freezing point of tissue relates to the percentage of frozen water. Furthermore, we provide experimental data for comparing this percentage with the increase in impedance. Measurements were performed on a bovine tissue sample at frequencies between 5 and 80 kHz. Slow cooling and heating rates were applied to minimize temperature gradients in the myocardial sample and to allow accurate assessment of the freezing point. Computer simulation was applied to link impedance with temperature dependent conductivities. The osmotic virial equation was used to estimate the percentage of frozen water. Measurements identified the freezing point at -0.6 <sup>∘</sup>C. At -5 <sup>∘</sup>C, impedance rose by more than a factor of ten compared to that at the freezing point and the percentage of frozen water was estimated as being 89%. At -49 <sup>∘</sup>C impedance had increased by up to three orders of magnitude and ice formation was most pronounced in the extracellular space. Progressive ice formation in tissue is reflected by a large increase in impedance, and impedance increases monotonically with the percentage of frozen water. Its analysis allows for experimental assessment of factors relevant to cell death. Solid ice contributes to the rupture of the micro-vasculature, while phase shifts reflect concentration differences between extra- and intracellular space driving osmotic water transfer across cell membranes.
Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays (2012)

Pathological high frequency oscillations (250-600 Hz) are present in the brains of epileptic animals and humans. The etiology of these oscillations and how they contribute to the diseased state remains unclear. This work identifies the presence of microstimulation-evoked high frequency oscillations (250-400 Hz) in dissociated neuronal networks cultured on microelectrode arrays (MEAs). Oscillations are more apparent with higher stimulus voltages. As with in vivo studies, activity is isolated to a single electrode, however, the MEA provides improved spatial resolution with no spread of the oscillation to adjacent electrodes 200 μm away. Oscillations develop across four weeks in vitro. Oscillations still occur in the presence of tetrodotoxin and synaptic blockers, and they cause no apparent disruption in the ability of oscillation-presenting electrodes to elicit directly evoked action potentials (dAPs) or promote the spread of synaptic activity throughout the culture. Chelating calcium with ethylene glycol tetraacetic acid (EGTA) causes a temporal prolongation of the oscillation. Finally, carbenoxolone significantly reduces or eliminates the high frequency oscillations. Gap junctions may play a significant role in maintaining the oscillation given the inhibitory effect of carbenoxolone, the propagating effect of reduced calcium conditions and the isolated nature of the activity as demonstrated in previous studies. This is the first demonstration of stimulus-evoked high frequency oscillations in dissociated cultures. Unlike current models that rely on complex in vivo recording conditions, this work presents a simple controllable model in neuronal cultures on MEAs to further investigate how the oscillations occur at the molecular level and how they may contribute to the pathophysiology of disease.
Toolkit-Based High-Performance Data Mining of Large Data on MapReduce Clusters (2009)

The enormous growth of data in a variety of applications has increased the need for high performance data mining based on distributed environments. However, standard data mining toolkits per se do not allow the usage of computing clusters. The success of MapReduce for analyzing large data has raised a general interest in applying this model to other, data intensive applications. Unfortunately current research has not lead to an integration of GUI based data mining toolkits with distributed file system based MapReduce systems. This paper defines novel principles for modeling and design of the user interface, the storage model and the computational model necessary for the integration of such systems. Additionally, it introduces a novel system architecture for interactive GUI based data mining of large data on clusters based on MapReduce that overcomes the limitations of data mining toolkits. As an empirical demonstration we show an implementation based on Weka and Hadoop.
Domain II of the HCV IRES is a potent activator of PKR (2010)

The protein kinase PKR is an essential component of the human innate immune response. In the presence of certain RNAs, PKR is autophosphorylated, which enables it to phosphorylate its substrate, eIF2α, leading to shut down of cellular translation. Activators of PKR are typically long double‐stranded RNAs (≥33 bp) present during viral infection. Recent studies have indicated that the internal ribosome entry site (IRES) in the 5’‐UTR of hepatitis C virus (HCV) RNA can also activate PKR 1 . The HCV IRES has a complex secondary structure consisting of four distinct domains. While it has been shown that domains III and IV of the IRES activate 1 , we report that Domain II can also potently activate PKR independent of the other IRES domains. We present analysis of the structural elements of this domain and find that while the double‐stranded helical regions of the RNA are important for activation, the loop regions of Domain II are also important. PKR activation by Domain II of the IRES alone has implications for the cell's immune response when the other domains of the IRES may be inaccessible during various stages of the HCV life cycle. Supported by NIH GM 58709
Abstract 9843: Proton Pump Inhibitors inhibit DDAH and processes underlying Idiopathic Pulmonary Fibrosis (2013)

Yohannes Ghebremariam, 2013 Finalist and Presenting Author
Detection and Genotyping Analysis of Human Papillomavirus Isolates from Liquid-Based Cervical Cytology Specimens (2009)

The detection of oncogenic subtypes of human papillomavirus (HPV) from exfoliated cervical cells collected in liquid-based preservative fluid at the time of the annual Pap test can be accomplished using PCR-based amplification methods. DNA sequence analysis of the L1 open reading frame (ORF) permits determination of the HPV viral subtype. DNA sequence analysis of the E6 and E7 ORFs permits further detection of various HPV genotype variants within a given HPV viral type. These techniques can be readily adopted by most laboratories employing standard molecular biology techniques.
A Differentiated Services Code Point (DSCP) for Capacity-Admitted Traffic (2010)

This document requests one DSCP from the IANA for real-time traffic
classes similar to voice conforming to the Expedited Forwarding Per
Hop Behavior, and admitted using a CAC procedure involving
authentication, authorization, and capacity admission, as compared to
a class of real-time traffic conforming to the Expedited Forwarding
Per Hop Behavior but not subject to capacity admission or subject to
very coarse capacity admission. It also recommends that certain
classes of video traffic described in RFC 4594 and which have similar
requirements be require admission using a CAC procedure involving
authentication, authorization, and capacity admission. One of the
reasons behind this is the need for classes of traffic that are
handled under special policies, such as the non-preemptive Emergency
Telecommunication Service, the US DoD's Assured Service (which is
similar to MLPP), or e-911. Capacity-admitted traffic classes need
separation from traffic not subject to admission control, from which
they can deterministically obtain their service requirements,
including SLA matters.
Reactions of tin(IV) chloride with silyl compounds. Part I. Reactions with inorganic silyl compounds (1975)

The reactions between SnCl4 and (SiH3)nX have been investigated [n= 1, X = H, F, Cl, Br, SiH3, Mn(CO)5, or Co(CO)4; n= 2, X = 0 or S; n= 3, X = N or P]; the reaction with (Me2SiH)2O was also investigated. With SiH4, Si2H6, SiH3F, SiH3Cl, [SiH3Mn(CO)5], and (SiH3)3N, reaction led to monochlorination at silicon, and spectroscopic parameters for the compounds SiH2FCl, [SiH2ClMn(CO)5], ClSiH2N(SiH3)2, (ClSiH2)2NSiH3, and (ClSiH2)3N, all prepared by this route, are reported. For the amines, 29Si and 15N chemical shifts were measured by heteronuclear double resonance. Reactions with other silyl compounds led to the formation of SiH3Cl, although some evidence was obtained for the formation of intermediate trichlorostannyl species.
Animal models of systemic lupus erythematosus and Sjögrenʼs syndrome (1990)

University of Alabama at Birmingham, Birmingham, Alabama, USA Current Opinion in Rheumatology 1990, 2:740-748
A transgenic red fluorescent protein‐expressing nude mouse for color‐coded imaging of the tumor microenvironment (2008)

The tumor microenvironment (TME) is critical for tumor growth and progression. We have previously developed color-coded imaging of the TME using a green fluorescent protein (GFP) transgenic nude mouse as a host. However, most donor sources of cell types appropriate for study in the TME are from mice expressing GFP. Therefore, a nude mouse expressing red fluorescent protein (RFP) would be an appropriate host for transplantation of GFP-expressing stromal cells as well as double-labeled cancer cells expressing GFP in the nucleus and RFP in the cytoplasm, thereby creating a three-color imaging model of the TME. The RFP nude mouse was obtained by crossing non-transgenic nude mice with the transgenic C57/B6 mouse in which the beta-actin promoter drives RFP (DsRed2) expression in essentially all tissues. In crosses between nu/nu RFP male mice and nu/+ RFP female mice, the embryos fluoresced red. Approximately 50% of the offspring of these mice were RFP nude mice. In the RFP nude mouse, the organs all brightly expressed RFP, including the heart, lungs, spleen, pancreas, esophagus, stomach, duodenum, the male and female reproductive systems; brain and spinal cord; and the circulatory system, including the heart, and major arteries and veins. The skinned skeleton highly expressed RFP. The bone marrow and spleen cells were also RFP positive. GFP-expressing human cancer cell lines, including HCT-116-GFP colon cancer and MDA-MB-435-GFP breast cancer were orthotopically transplanted to the transgenic RFP nude mice. These human tumors grew extensively in the transgenic RFP nude mouse. Dual-color fluorescence imaging enabled visualization of human tumor-host interaction. The RFP nude mouse model should greatly expand our knowledge of the TME.
Phase Behavior of Lanthanum Strontium Manganites (1999)

The phase stability of Sr‐doped (LSM) perovskite in the La‐Sr‐Mn‐O system was investigated as a function of Sr content and A/B cation ratio. The perovskite structure changed with both Sr content and A/B cation ratio. As the Sr content was increased to 0.2 mol, the perovskite structure adopted an orthorhombic distortion. This changed to a monoclinic or hexagonal structure for 0.2 ≤ Sr ≤ 0.3 mol. When the Sr content increased to 0.3 mol, the structure reverted to orthorhombic symmetry. Data from X‐ray powder diffractometry, scanning electron microscopy, transmission electron microscopy, and energy‐dispersive X‐ray emission spectroscopy, showed that secondary phases in the La‐Sr‐Mn‐O system were underdeveloped with respect to changes of the doped Sr content, A/B cation ratio, and thermal history. X‐ray detectable minor phases present in the LSM material were , , , , , and . © 1999 The Electrochemical Society. All rights reserved.
Safe use of X window system protocol across a firewall (1995)

This paper describes a method for safe use of the X window system protocol across a firewall. The approach uses an agent in the communications stream to enforce an access control policy. Topics covered include risks, policy, implementation, and a summary of prototype efforts. Results can be applied to other distributed or client/server applications.
Plant Anticancer Agents, XLIV. Cytotoxic Constituents from Stizophyllum riparium (1987)

Bioactivity-guided fractionation of a CHCl3 extract of Stizophyllum riparium has afforded six new compounds, namely, the triterpene esters, 3 beta-hydroxy-24-transferulyloxyurs-12-en-28-oic acid, 3 beta-hydroxy-24-cis-ferulyloxyurs-12-en-28-oic acid, 3 beta, 19-dihydroxy-24-trans-ferulyloxyurs-12-en-28-oic acid, and the pregnane derivatives, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7,16-trien-20-one, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one, and 16 alpha-methoxy-2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one. The structures of these isolates were established by spectroscopic and chemical methods. Compounds 1, 2, and 4 exhibited cytotoxic activity against the P-388 lymphocytic leukemia test system in cell culture.
Transverse mode controlled in inGaAsP inP lasers at 1.5 µm range with buffer-layer loaded piano-convex waveguide (BL-PCW) structures (1981)

A modified plano-convex waveguide structure is studied analytically and successfully applied to InGaAsP/InP lasers in the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.5- 1.6 \mu</tex> m wavelength region to realize stable transverse mode operation. The structure of these lasers is characterized by a standard buffer layer between an active layer and an upper cladding layer and a waveguide layer of varying thickness between the active layer and the substrate. A theoretical analysis of this structure showed that, for a given channel depth, increases in buffer-layer thickness give rise to larger maximum channel widths of the substrate for fundamental transverse mode operation. It was also shown that the optical confinement factor in the active layer decreases little as the buffer-layer thickness is increased from 0.1 to 0.3 μm. Buffer-layer loaded plano-convex waveguide lasers in the 1.5 μm range were prepared by liquid phase epitaxy and fundamental transverse mode operation up until <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I = 2I_{th}</tex> was obtained. The dc threshold current was 100-300 mA and the differential quantum efficiency per facet was 10-15 percent. Continuous CW operation for over 2000 h at 25°C has been achieved.
Editor’s Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption (2017)

Evaluating the potential for methylmercury (MeHg) toxicity relies on accurately predicting the mercury (Hg) body burden that results from eating fish. Hg body burden is directly determined by the slow elimination kinetics of MeHg in the human body (kel = 0.014 days-1 or t1/2 =50 days). Existing studies on MeHg half-life in humans demonstrate a wide range values (t1/2 = 30 to >150 days) and has lead to uncertainty in the derivation of a regulatory standard for acceptable daily oral intake. The causes of variation in MeHg toxicokinetics in humans remain little explored. Here we characterize variation in human MeHg metabolism and elimination rate (kel) in 37 adult volunteers who consumed 3 fish meals. We determined MeHg elimination rates via longitudinal Hg analysis in single hairs using laser ablation inductively coupled plasma mass spectrometry. We also measured MeHg metabolism (biotransformation) via speciation of fecal Hg. We find an average kel = 0.0157 days-1 (t1/2 = 44 days) amongst a more than 2-fold variation in kel across the cohort (0.0248-0.0112 days-1; t1/2 = 28-62 days). Although MeHg biotransformation varied widely between individuals, it showed a positive association with elimination rates across the cohort. A more than 2-fold change in kel over a period of 2 years was seen in some individuals. In 2 individuals, who received antibiotic for unrelated health issues, elimination rate was seen to slow significantly. Associations of kel with age, body mass index, gender, and fish eating habits were not observed. We establish that a measure of methylmercury metabolism and eliminaiton status (MerMES) can reduce uncertainty in determining an individual's MeHg toxicokinetics subsequent to eating fish.