gebhart/patrepeval huggingface dataset:
Diagnostic Yield of Bronchoalveolar Lavage Is Low in Allogeneic Hematopoietic Stem Cell Recipients Receiving Immunosuppressive Therapy or with Acute Graft-versus-Host Disease: The St. Jude Experience, 1990-2002 (2007)

Management of pulmonary complications after hematopoietic stem cell transplantation (HSCT) often includes bronchoalveolar lavage (BAL), but the diagnostic yield of BAL remains unclear in pediatric HSCT patients. We reviewed the records of 78 allogeneic and 11 autologous transplant recipients who underwent BAL after HSCT at St. Jude Children’s Research Hospital (1990-2002). We analyzed donor and recipient information, clinical variables, adverse events during bronchoscopy, outcome, and medical management at the time of the procedure to determine the diagnostic yield of BAL and factors that affect its success. Seventy-eight allogeneic and 11 autologous transplant recipients underwent BAL at a median of 68 days (range, 6-528 days) and 23 days (range, 6-705 days) after HSCT, respectively. The median age at the time of BAL was 12.2 years (0.8-23.5 years) in allogeneic patients and 16.9 years (4.8-26.2 years) in autologous patients. The most common indications for BAL in both populations were fever, hypoxia, and abnormality on chest auscultation. BAL identified an etiology in 53 allogeneic (67.9%) and 7 autologous (63.6%) patients (BAL positive); only 1 etiology was identified in 30 of the 53 allogeneic patients (56.6%). The most common finding was bacterial infection in both allogeneic (59.0%) and autologous (71.4%) patients. Of 39 allogeneic patients who had concurrent extrapulmonary infection, 30 (76.9%) had a positive BAL. Seven (9.0%) allogeneic patients experienced hypoxia (generally transient) during bronchoscopy. Approximately 68% of those with a positive BAL were receiving immunosuppressive therapy, whereas 96% of patients with a negative BAL were receiving immunosuppressive therapy (P = .008). Further, 26.4% of the BAL-positive cohort had grade II-IV acute graft-versus-host disease (aGVHD), whereas 60% of the BAL-negative group had grade II-IV aGVHD (P = .004). In our experience, the safety and diagnostic yield of BAL in this set of patients is relatively high, but the likelihood of informative findings is reduced among allogeneic recipients with grade II-IV aGVHD and those receiving immunosuppressive therapy.
Thoracic 131I Uptake After Previous Pneumonectomy in Patients Treated for Differentiated Thyroid Cancer (2012)

In patients treated for differentiated thyroid cancer with radioiodine (131I), abnormal uptake on post-therapeutic whole-body scan may lead to repeated administration of 131I. Uptake not linked to thyroid cancer but to other conditions should be recognized so that patients are not overtreated. We describe 3 cases of unilateral thoracic 131I uptake in patients previously treated by pneumonectomy for lung cancer, without evidence of persistent lung cancer.
Real-time system design environment for multi-channel high-speed data acquisition system and pattern recognition (2003)

The Design Real-Time 2.0 software environment provides the user with a set of tools to create a real-time fully programmable system which can sustain a rate of several MHz from multi-channel inputs, can extend processing time in a pipeline stage and can provide a result within a few hundred ns. The tool set allows the user to (a) create applications of different sizes with different throughput and filtering algorithms; (b) select the processor speed, internal bus width, lookup tables, number of input and output result bits for each set of data received at each channel for each algorithm execution; (c) simulate a specific parallel-processing system for a given algorithm on different sets of data; (d) monitor the system in real time via an RS232 interface; (e) create a hardware component (FPGA or ASIC) by means of interfacing to the Electronic Design Automation (EDA) tools. The advantage of these tools is that of allowing simulation, before construction, of an entire programmable high-speed data acquisition and processing system, and selection of the processor speed, bus width and real-time algorithm which is most cost effective for a specific application where general-purpose processors fail in speed and performance. Benefits derived from the use of the novel architecture and cost comparisons with respect to similar designs are also provided.
D<inf>n</inf>-FTR: Fault-tolerant routing algorithm for Mesh based network-on-chip (2018)

Fault tolerant routing algorithms are important concern in the design of Network-on-Chip (NoC) as they have direct effect on the performance of the system. In this paper, we have proposed a new fault tolerant algorithm named Dn-FTR which takes care of the router and link failures in the network and still be able to provide paths in the network for the given source destination pairs. The proposed algorithm has been tested for the performance and scalability and it has been shown that the proposed algorithm produces better results compared to the recent fault-tolerant routing algorithms in the literature. Cases where the previous algorithms fail and the proposed algorithm could provide the paths have also been discussed. Experimental results show that the proposed algorithm gives superior performance by reducing number of hops compared to the existing routing algorithms.
Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism (2004)

Human paraoxonase 1 (PON-1) is a serum high-density lipoprotein-associated enzyme mainly secreted by the liver. It has endogenous and exogenous substrates and displays protective properties with respect to cardiovascular disease and organophosphate intoxication. In the HuH7 human hepatoma cell line, PON-1 activity and mRNA levels were increased by dietary polyphenolic compounds such as quercetin but also by toxic ligands of the aryl hydrocarbon receptor (AhR) such as 3-methylcholanthrene (3-MC). However, the 2,3,7,8-tetrachlorobenzo(p)dioxin (TCDD) was a poor inducer. Transient and stable transfection assays indicated that these compounds increased the PON-1 gene promoter activity in an AhR-dependent manner, since their effect was inhibited by 7-keto-cholesterol and AhR-directed short interfering RNA. Deletions and mutations studies showed that a xenobiotic responsive element (XRE)-like sequence within the PON-1 promoter mediated the effect of 3-MC and quercetin. In contrast with consensus XREs from the cytochrome P450 1A1 gene, the PON-1 XRE-like element mediated preferentially the effect of quercetin compared to the results seen with TCDD. Furthermore, AhR binding to this element was preferentially activated by quercetin. These observations provide a molecular mechanism for the regulation of the cardioprotective enzyme PON-1 by polyphenols. They suggest also that AhR ligands may differentially regulate gene expression depending on the DNA target sequence.
Thermodynamics of Molecular Reorientationally Disordered Phases at High Pressure (1979)

Abstract Thermodynamic properties of solid benzene and furan are investigated through Swenson's equaiotn of state. It is found that those two solids, in their dynamic disordered state, behave like cubic crystals from the thermodynamic point of view. In particular, this means that the crystal lattice configuration remains constant at constant volume, which is supported by previous high pressure low frequency Raman measurements. This behaviour seems to be restricted to the reorientationally disordered phases. The relations between thermodynamics, local crystal configuration and dynamic disorder in molecular crystals is discussed in terms of atom-atom pair wise potentials, Frenkel's model of molecular reorientations between discrete wells and the rotational diffusion model.
Síntese e polimerização de monômeros acrílicos funcionalizados (2003)

A converso de epxidos em outros anis heterocclicos apresenta-se como uma rota sinttica promissora para obteno de monmeros acrlicos com reatividade semelhante ao
Array sensing using optical methods for detection of chemical and biological hazards (2013)

By mimicking the mammalian senses of taste and smell, artificial arrays of cross-reactive receptors have found use in a variety of sensing applications. Pattern recognition algorithms allow these arrays to be used for discriminating analytes and even for predicting the identity of unknown analytes. Furthermore, in selecting a signaling method for these assays, the choice of optical detection is particularly desirable due to its high sensitivity and the associated convenient instrumentation. This tutorial review provides a brief introduction to array sensing using optical detection and chemometrics. While differential sensing approaches have been used for a number of applications, this review focuses on progress towards the detection of chemical and biological hazards.
Sugars in Natural and Artificial Pollen Germination Substrates (1977)

The stigmatic exudates and pollen grains of five unrelated species were tested for sugars. Glucose, fructose, and sucrose were found in the stigmatic fluid of Yucca aloifolia L. and glucose and fructose in that of Oenothera adrummondii Hook. In in vitro experiments with Y. aloifolia pollen, high germination percentages were obtained in artificial media containing glucose or sucrose. Fructose, which is present in the stigmatic fluid of the Yucca sp. resulted in high in vitro pollen germination only when borate and calcium were added to the medium. Presence of bound sugars is indicated in the stigmatic secretion of Citrus aurantium L. and pollen of the single plant tested germinated at a low percentage in artificial sugar media. No sugars were detected in the stigmatic fluids of Hemerocallis fulva L. and Zea mays L. and in these two species in vitro pollen germination in sugary media was negligible or absent. The pollen grains of all five species contain sucrose and those of Oenothera and Citrus also reducing sugars.
Remodeling of human adipose tissue to metabolically favorable profile requires PI3K activation. (2007)

Previously, we showed that experimental infection of rodents with a human adenovirus, Ad‐36, results in insulin sensitivity and increased adiposity. In vitro Ad‐36 infection of human adipocyte progenitors up‐regulates PI3 Kinase signaling pathway, and increases differentiation and lipid accumulation. We investigated the ability of Ad‐36 to remodel adipose tissue via PI3 Kinase activation by infecting human adipose tissue explants in the presence or absence of Wortmannin (WM), a well‐characterized PI3 Kinase inhibitor. We assessed adipose tissue remodeling by measuring markers for adiposity (PPARγ2, aP2), angiogenesis (PECAM‐1), insulin sensitivity (adiponectin, FAS), and inflammation (MCP‐1). Collectively, these results suggest that Ad‐36 remodels human adipose tissue to exhibit greater adipogenesis, angiogenesis, insulin sensitivity and favorable inflammatory cytokine profile, which requires PI3 Kinase activity. Potential of Ad‐36 to remodel adipose tissue may provide therapeutic targets for remodeling unfavorable adipose tissue profile common in obesity, diabetes and metabolic syndrome. Funded by NIH R‐01 DK066164. Fold change in gene expression by qRT‐PCR (p&lt; .05). Ad‐36 group is compared to uninfected control. (Ad‐36 + WM) group is compared to Ad‐36 alone.
New deep level luminescence bands observed from both a SiGe alloy layer and Si/Ge superlattice structures (1991)

Photoluminescence measurements have been made on Si/Ge short period superlattice structures grown on a SiGe alloy buffer layer and on a similar SiGe alloy layer without a superlattice. Using an InSb detector with a low energy cutoff at ∼450 meV, the major luminescence features observed were two broad bands with maximum intensities at ∼530 and ∼720 meV. The luminescence intensity was found to vary with the superlattice composition but was substantially stronger for the SiGe alloy layer without a superlattice. We ascribe these luminescence features to defects in the SiGe alloy layers. This is supported by the observation that the introduction of deliberate copper contamination at 600 °C dramatically increases the photoluminescence signal.
A quantitative investigation of electron detrapping in SiO2 under Fowler–Nordheim stress (1992)

Detrapping of the trapped electrons from the acceptorlike trapping sites in SiO2 under Fowler–Nordheim (FN) stress has been quantitatively investigated using Al/SiO2/Si capacitor structures. Before FN stress, the traps were charged using the avalanche electron injection technique to enhance subsequent detrapping, and facilitate its distinction from trapping in subsequent studies. The quantity of electrons detrapped was assessed from the shift in the electrical field strength near the cathode. Under FN stress with an electrical field of 8 MV/cm or over, the probability of captured electrons remaining trapped was found to be less than 20%. This probability was insensitive to the number of electrons initially trapped in the oxide, decreasing as the stressing field strength increases. Within the experimental range of this study, the transient behavior of electron detrapping cannot be satisfactorily described by the dynamic balance model and a new model is developed based on the reactions occurring in the oxide under FN stress. It is found that there is more than one mechanism contributing to the electron detrapping and that the detrapping efficiency is unrelated to the initial capture cross sections of traps.
2D mapping of cluttered indoor environments by means of 3D perception (2004)

This paper presents a combination of a 3D laser sensor and a line-base SLAM algorithm which together produce 2D line maps of highly cluttered indoor environments. The key of the described method is the replacement of commonly used 2D laser range sensors by 3D perception. A straightforward algorithm extracts a virtual 2D scan that also contains partially occluded walls. These virtual scans are used as input for SLAM using line segments as features. The paper presents the used algorithms and experimental results that were made in a former industrial bakery. The focus lies on scenes that are known to be problematic for pure 2D systems. The results demonstrate that mapping indoor environments can be made robust with respect to both, poor odometry and clutter.
Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo (2019)

Regulation of gene expression is an important aspect of insulin action but in vivo is intertwined with changing levels of glucose and counter-regulatory hormones. Here we demonstrate that under euglycemic clamp conditions, physiological levels of insulin regulate interrelated networks of more than 1,000 transcripts in muscle and liver. These include expected pathways related to glucose and lipid utilization, mitochondrial function, and autophagy, as well as unexpected pathways, such as chromatin remodeling, mRNA splicing, and Notch signaling. These acutely regulated pathways extend beyond those dysregulated in mice with chronic insulin deficiency or insulin resistance and involve a broad network of transcription factors. More than 150 non-coding RNAs were regulated by insulin, many of which also responded to fasting and refeeding. Pathway analysis and RNAi knockdown revealed a role for lncRNA Gm15441 in regulating fatty acid oxidation in hepatocytes. Altogether, these changes in coding and non-coding RNAs provide an integrated transcriptional network underlying the complexity of insulin action.
Diffractive backlight grating array for mobile displays (2008)

Abstract— The display backlight unit (BLU) is the most power‐consuming subunit in mobile liquid‐crystal displays. The state‐of‐the‐art BLUs utilize scattering, refractive, and reflective microstructures to generate a uniform distribution of white light through the display. More effective means of transmitting light through the display color filters could be obtained by using diffraction, but previously proposed diffractive backlights do not fully utilize all the possibilities to design gratings effectively for optimal color separation and outcoupling. This paper presents a new pixelated diffractive backlight grating array as an approach for overcoming these obstacles in BLU design. A model array was fabricated to couple out red, green, and blue primary colors from the respective subpixel locations. The results show that it is possible to manufacture such an array and that the light couples out as intended, giving a starting point to design mobile‐display modules with low light‐transmission losses.
Plasma-free atomic layer deposition of Ru thin films using H2 molecules as a nonoxidizing reactant (2016)

The ruthenium (Ru) thin films were grown by atomic layer deposition (ALD) using a sequential supply of dicarbonyl-bis(5-methyl-2,4-hexanediketonato) Ru(II) (C16H22O6Ru) and H2 as a reactant at a substrate temperature of 250 °C. Deposition was possible using H2 molecules without a plasma by increasing the chamber pressure to above 10 Torr. Specifically, high-quality Ru films with a low resistivity of ∼40 μΩ cm and few amount of oxygen (∼1.2 at. %) were obtained under a chamber pressure of 300 Torr though the oxygen was contained in the precursor. Under the optimized conditions, self-limited film growth with regard to the precursor and reactant pulsing times was confirmed under elevated chamber pressures. The ALD-Ru process proposed in this study showed one of the highest growth rates of 0.12 nm/cycle on a thermally grown SiO2 substrate, as well as a very low number of incubation cycles (approximately 12 cycles). Cross-sectional view transmission electron microscopy showed that no interfacial oxide had formed during the deposition of the ALD-Ru films on a W surface using H2 molecules, whereas ∼7 nm thick interfacial oxide was formed when O2 molecules were used as a reactant. The step coverage of the ALD-Ru film onto very small-sized trenches (aspect ratio: ∼4.5 and the top opening size of 25 nm) and holes (aspect ratio: ∼40 and top opening size of 40 nm) was excellent (∼100%).
Watch brain circulation in unexplained progressive myelopathy: a review of Cognard type V arterio-venous fistulas (2023)

We confirmed CVFs' broad clinical spectrum of presentation and found that the outcome is not associated with the severity of the clinical picture at onset, but it has a negative correlation with the length of diagnostic delay. We furthermore underlined the importance of cervico-dorsal perimedullary T1/T2 flow voids as a reliable MRI parameter to orient the diagnosis and distinguish CVFs from most of their mimics.
A fast video haze removal algorithm via mixed transmissivity optimisation (2019)

Image restoration is an important approach to image and video defogging. One of the most popular algorithms for image restoration is dark channel prior. However, when the algorithm is applied to outdoor digital webcams with limited computing resources, its real-time performance probably cannot be guaranteed. To address the above issue, this paper presents a fast video haze removal algorithm based on mixed optimised transmissivity to improve the time performance of the dark channel prior algorithm. The proposed algorithm combines guided filter and median filter and replaces the soft matting procedure in the classical dark channel prior algorithm. A set of experiments are performed to evaluate the real-time performance and effectiveness of the algorithm. The results show that our proposed improved algorithm can significantly improve the speed of video defogging, without sacrificing much effectiveness in identification of target objects.
Spectroscopy measurement of local chemiluminescence of a micro flame (2003)

A spectroscopy measurement of local chemiluminescence of a micro flame was conducted in the present study in order to know effects of atmosphere temperature and wall temperature on radical distribution in the vicinity of surface. Local chemiluminescence of a micro flame was measured by Cassegrain optical system and ICCD spectroscope system with changing burner diameters and flow rate. Intensity of chemiluminescence of OH radical was relatively stronger in the vicinity of a small scale burner outlet in the cases of premixed supply of oxygen and methane.
Enhancement of the Proapoptotic Properties of Newcastle Disease Virus Promotes Tumor Remission in Syngeneic Murine Cancer Models (2015)

Newcastle disease virus (NDV) is considered a promising agent for cancer therapy due to its oncolytic properties. These include preferential replication in transformed cells, induction of innate and adaptive immune responses within tumors, and cytopathic effects in infected tumor cells due to the activation of apoptosis. To enhance the latter and thus possibly enhance the overall oncolytic activity of NDV, we generated a recombinant NDV encoding the human TNF receptor Fas (rNDV-B1/Fas). rNDV-B1/Fas replicates to similar titers as its wild-type (rNDV-B1) counterpart; however, overexpression of Fas in infected cells leads to higher levels of cytotoxicity correlated with faster and increased apoptosis responses, in which both the intrinsic and extrinsic pathways are activated earlier. Furthermore, in vivo studies in syngeneic murine melanoma models show an enhancement of the oncolytic properties of rNDV-B1/Fas, with major improvements in survival and tumor remission. Altogether, our data suggest that upregulation of the proapoptotic function of NDV is a viable approach to enhance its antitumor properties and adds to the currently known, rationally based strategies to design optimized therapeutic viral vectors for the treatment of cancer.
X‐ray synchrotron diffraction study of natural gas hydrates from African margin (2007)

Natural gas hydrates recovered from the Congo‐Angola basin and Nigerian margins are analyzed by synchrotron X‐ray powder diffraction. Biogenic methane is the most abundant gas trapped in the samples and others minor components (CO 2 , H 2 S) are co‐clathrated in a type I cubic lattice structure. The refinement for the type I structure gives lattice parameters of a = 11.8646 (39) Å and a = 11.8619 (23) Å for specimens from Congo‐Angola and Nigerian margins respectively at 90 K. These values, intermediate between the lattice constant of less pure methane specimens and pure artificial methane hydrates, indicate that lattice constants can be affected by the presence of encaged CO 2 , H 2 S and other gas molecules, even in small amounts. Thermal expansion is also presented for Congo‐Angola hydrate in the temperature range 90–200 K. The coefficients are comparable with values reported for synthetic hydrates at low temperature and tend to approach thermal expansion of ice at higher temperature.
Studying the effectiveness of application performance management (APM) tools for detecting performance regressions for web applications (2016)

Performance regressions, such as a higher CPU utilization than in the previous version of an application, are caused by software application updates that negatively affect the performance of an application. Although a plethora of mining software repository research has been done to detect such regressions, research tools are generally not readily available to practitioners. Application Performance Management (APM) tools are commonly used in practice for detecting performance issues in the field by mining operational data.