gebhart/patrepeval huggingface dataset:
IMM estimation for multitarget-multisensor air traffic surveillance (2002)

This paper deals with the design and implementation of an algorithm for track formation and maintenance in a multisensor air traffic surveillance (ATS) scenario. The major contribution of the present work is the development of the combined likelihood function that enables the replacement of the Kalman filter (KF) with the much more versatile interacting multiple model (IMM) estimator which accounts for the various motion modes of the aircraft. This likelihood function defines the objective function used in the measurement to track assignment algorithm. Data from two FAA radars are used to evaluate the performance of this algorithm. The use of the IMM estimator yields considerable noise reduction during uniform motion, while maintaining the accuracy of the state estimates during maneuver. Overall, the mean square prediction error (to the next observation time) is reduced by 30% and the RMS errors in the altitude rate estimates are reduced by a factor of 3 over the KF. The usefulness of the tracker presented here is also demonstrated on a non-cooperative target.
Cell-mediated immunity after pertussis vaccination and after natural infection. (1997)

The aim of this study was the investigation of the specific cell-mediated (CMI) responses induced by DTaP and to compare these data to immunity after natural infection. The ability of peripheral blood T-lymphocytes to respond to the pertussis related antigens pertussis-toxin (PT), filamentous haemagglutinin (FHA), and Pertactin (PRN) was investigated in 40 children before vaccination and at different times after vaccination with DTaP (Infanrix) by measurement of antigen-specific proliferation, lymphocyte phenotype, cytokine production and expression of activation markers (CD25, HLADR). Similar investigations were performed in children 4-6 weeks after recovery from natural pertussis. DTaP created a specific T-cell-response to PT, FHA and PRN that increased continually, depending on the progress of the vaccination schedule. In contrast to waning antibody titres, CMI was stable even between the post-basic vaccination and the pre-booster period. The magnitude of CMI after DTaP equalled those after natural infection. Measurement of cytokine-pattern showed induction of IFN-tau-producing T-helper-1-cells with lower stimulation of IL 10-producing T-helper-2-cells for DTaP and natural infection. Our data indicate that DTaP-vaccination induces a potent immune response to PT, FHA, and PRN at least equivalent to CMI after natural infection. The finding of a preferential T-helper-1-induction after DTaP and natural infection suggests a role of IFN gamma-activated macrophages in the protective response against B. pertussis-induced disease.
Chemokines and CD40 expression in human fibroblasts (2000)

Chemokines are cytokines specialized for recruiting leukocytes in inflammatory responses. Recent data indicate that besides macrophages and leukocytes fibroblasts may also be a source of these important immune molecules. We assayed chemokine expression (mRNA/ protein) in cultured fibroblasts isolated from a variety of human tissues and different pathologic states: normal bone marrow vs. myelometaplastic spleen, normal lung vs. metastasis stroma, and normal breast vs. radiation fibrosis and tumor stroma. In all fibroblasts, transcripts for chemokines IL-8, stromal cell-derived factor-1, monocyte chemotactic protein (MCP)-1 and eotaxin were detected. Although the production of IL-8 was abundant in most of the fibroblasts studied, fibroblasts from lung and pathologic breast tissue produced significantly less. Conversely, eotaxin production was low in most fibroblasts except in those isolated from myelometaplastic tissue where it was highly produced. Moreover, chemokines MCP-4, RANTES and macrophage inflammatory protein-1alpha were found to be expressed only in fibroblasts from select tissues. When the expression of CD40, an activating surface molecule for immune cells, was investigated, we found that most of the fibroblasts expressed this antigen. Overall these results indicate that cultured human fibroblasts from various tissues and pathologic settings produce a distinct panel of chemokines and express CD 40, suggesting a possible fundamental role of fibroblasts in immune responses and disease processes.
Genetic Deletion of Placenta Growth Factor in Mice Alters Uterine NK Cells (2007)

Placenta growth factor (PlGF; formerly PGF), a vascular endothelial growth factor gene family member, is expressed in human implantation sites by maternal uterine NK (uNK) and fetal trophoblast cells. Lower than normal concentrations of blood and urinary PlGF have been associated with impending onset of pre-eclampsia, a hypertensive disease of late human gestation characterized by limited intravascular trophoblast invasion. In pregnant rodents, delivery of the PlGF antagonist sFlt-1 or S-endoglin induces pre-eclampsia-like lesions. Mice genetically deleted in PlGF reproduce, but neither their implantation sites nor their uNK cell development are described. We combined real-time PCR of endometrium from nonpregnant and gestation day (gd)6-18 C57BL6/J (B6) mice with immunohistology to analyze PlGF expression in normal mouse pregnancy. To estimate the significance of uNK cell-derived PlGF, PlGF message was quantified in mesometrial decidua from pregnant alymphoid Rag2 null/common gamma chain null mice and in laser capture-microdissected B6 uNK cells. Histopathologic consequences from PlGF deletion were also characterized in the implantation sites from PlGF null mice. In B6, decidual PlGF expression rose between gd8-16. uNK cells were among several types of cells transcribing PlGF in decidualized endometrium. Immature uNK cells, defined by their low numbers of cytoplasmic granules, were the uNK cells displaying the greatest number of transcripts. PlGF deletion promoted the early differentiation high numbers of binucleate uNK cells (gd8) but had no other significant, morphometrically detectable impact on implantation sites. Thus, in mice, PlGF plays an important role in successful uNK cell proliferation and/or differentiation.
Oral Delivery Mediated RNA Interference of a Carboxylesterase Gene Results in Reduced Resistance to Organophosphorus Insecticides in the Cotton Aphid, Aphis gossypii Glover (2014)

The results of this study not only suggest that ingestion of dsRNA through artificial diet could be exploited for functional genomic studies in cotton aphids, but also indicate that CarE can be considered as a major target of organophosphorus insecticide (OPs) resistance in A. gossypii. Further, our results suggest that the CarE would be a propitious target for OPs resistant aphid control, and insect-resistant transgenic plants may be obtained through plant RNAi-mediated silencing of insect CarE expression.
Conversion of biomass into chemicals with high-temperature wet oxidation (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of biomass into chemicals with high-temperature wet oxidationGary D. McGinnis, Wilber W. Wilson, Shawn E. Prince, and Chyi Cheng ChenCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 4, 633–636Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/i300012a022https://doi.org/10.1021/i300012a022research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Perioperative Transesophageal Echocardiographic Diagnosis of Membranous Interventricular Septal Aneurysm in Two Patients (2016)

ABSTRACT Aneurysms of interventricular septum are a rare anomaly usually seen as an incidental finding on echocardiography. Rarely, they can cause right ventricular outflow tract obstruction. They can present in patients having other cardiac lesions. Diagnosis of interventricular septal aneurysm is not straightforward. They can be confused with sinus of valsalva aneurysm or ventricular septal defect on transthoracic echocardiography. Transesophageal echocardiography (TEE) provides a better alternative to delineate the interventricular septal aneurysm. We describe the TEE diagnosis of membranous interventricular septal aneurysm in two dissimilar patients who presented for cardiac surgery at our cardiac center. How to cite this article Dutta V, Negi SL, Puri GD, Singh RS. Perioperative Transesophageal Echocardiographic Diagnosis of Membranous Interventricular Septal Aneurysm in Two Patients. J Perioper Echocardiogr 2016;4(1):14-16.
CCDC 100110: Experimental Crystal Structure Determination (1998)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Multi-aspect profiling of kernel rootkit behavior (2009)

Kernel rootkits, malicious software designed to compromise a running operating system kernel, are difficult to analyze and profile due to their elusive nature, the variety and complexity of their behavior, and the privilege level at which they run. However, a comprehensive kernel rootkit profile that reveals key aspects of the rootkit's behavior is helpful in aiding a detailed manual analysis by a human expert. In this paper we present PoKeR, a kernel rootkit profiler capable of producing multi-aspect rootkit profiles which include the revelation of rootkit hooking behavior, the exposure of targeted kernel objects (both static and dynamic), assessment of user-level impacts, as well as the extraction of kernel rootkit code. The system is designed to be deployed in scenarios which can tolerate high overheads, such as honeypots. Our evaluation results with a number of real-world kernel rootkits show that PoKeR is able to accurately profile a variety of rootkits ranging from traditional ones with system call hooking to more advanced ones with direct kernel object manipulation. The obtained profiles lead to unique insights into the rootkits' characteristics and demonstrate PoKeR's usefulness as a tool for rootkit investigators.
Temperature dependence of the reduction potential of blue copper in fungal laccase (1982)

Thin-layer spectroelectrochemical methods have been employed to measure the reduction potentials of the blue copper in Polyporus versicolor laccase (EC 1.10.3.2) between 7 degrees C and 41 degrees C (0.2 M sodium phosphate, pH 5.4). Thermodynamic parameters are: DeltaS degrees = -13.9 +/- 2 cal/mol-K; DeltaH degrees = -22.1 +/- 0.5 kcal/mol; E degrees (25 degrees C) = 780 +/- 3 mV vs. the normal hydrogen electrode. Comparison of the DeltaS degrees and DeltaH degrees values with those for single-site proteins suggests that the high potential of the blue copper in fungal laccase is attributable mainly to stabilization of the copper (I) center by enhanced ligand binding interactions and that protein solvation effects play a lesser role.
The pigmentary system : physiology and pathophysiology (1998)

PART I: THE PHYSIOLOGY OF THE PIGMENTARY SYSTEM SECTION 1: HISTORICAL & COMPARATIVE PERSPECTIVES OF THE PIGMENT SYSTEM SECTION 2: THE MORPHOLOGY, DISTRIBUTION & BIOLOGY OF THE PIGMENT CELL SECTION 3: THE MOLECULAR BIOLOGY OF THE PIGMENT CELL SECTION 4: CHEMISTRY & PHYSICS OF MELANIN AND ENZYMOLOGY OF MELANIN SYNTHESIS PART II: THE PATHOPHYSIOLOGY OF THE PIGMENTARY SYSTEM SECTION 5: AN OVERVIEW OF HUMAN SKIN COLOR AND ITS DISORDERS SECTION 6: DISORDERS OF HYPOPIGMENTATION AND DEPIGMENTATION SECTION 7: DISORDERS OF HYPERPIGMENTATION SECTION 8: TREATMENT OF PIGMENTARY DISORDERS
Phasor-Measurement-Based State Estimation for Synchrophasor Data Quality Improvement and Power Transfer Interface Monitoring (2014)

Validation and data quality improvement of phasor data through state estimation is the first step in ensuring that the synchrophasor data is useful for applications in monitoring, visualization, and control. This paper presents a phasor-measurement-based state estimator (PSE) for improving data consistency by identifying angle biases and current scaling errors in the phasor data using the augmented state vector approach. These errors can arise from issues with the Global Positioning Signal (GPS), timing circuits, instrument channels, and/or data channel scaling. The PSE is demonstrated using several sets of disturbance data from the Central New York Power System. The PSE can also provide estimates of line parameters and transformer tap ratios with sufficient measurement redundancy. Finally, the PSE allows the computation of interface power flows for disturbance and stability monitoring.
Significant enhancement of the electrical transport properties of graphene films by controlling the surface roughness of Cu foils before and during chemical vapor deposition (2014)

We have studied the influence of the surface roughness of copper foils on the sheet resistance of graphene sheets grown by chemical vapor deposition. The surface roughness of the copper foils was reproducibly controlled by electropolishing. We have found that the graphene sheet resistance monotonically decreases as the surface roughness of the copper foils decreases. We show that a pre-annealing treatment combined with an optimized electropolishing process of the Cu foils and a fast CVD growth prevents the evolution of the Cu surface roughness during graphene synthesis. This combination of fabrication conditions produces small grain polycrystalline graphene films with a sheet resistance of 210 Ω □(-1) and carrier mobility values as high as 5450 cm(2) V(-1) s(-1) after transfer onto SiO2/Si.
Solid lipid nanoparticles of anticancer drug andrographolide: formulation,in vitroandin vivostudies (2013)

Diterpenoidal anti-cancer drug andrographolide (AD) was encapsulated into solid lipid nanoparticle (SLN) because of poor aqueous solubility and high lipophilicity. AD-SLNs were prepared by solvent injection method and characterized for droplet size, surface morphology, zeta potential, etc. In vitro drug release was carried out by dialysis-membrane method. A pharmacokinetic study was performed by UPLC/Q-TOF-MS method to determine the maximum plasma concentration (Cmax), area under the curve (AUC), etc. There was an improvement in Cmax and AUC of AD-SLNs when compared with AD, thereby enhancing the bioavailability of AD. The tmax was increased than that of AD suspension, indicating the sustained release pattern of AD-SLNs. The antitumor activity was carried out on Balb/c mice showing better results with AD-SLNs as compared to AD. Thus, the AD-loaded SLNs would be useful for delivering poorly water-soluble AD with enhanced bioavailability and improved antitumor activity.
Executing a composite VLIW instruction having a scalar atom that indicates an iteration of execution (2023)

A processor core includes a storage device which stores a composite very large instruction word (VLIW) instruction, an instruction unit which obtains the composite VLIW instruction from the storage device and decodes the composite VLIW instruction to determine an operation to perform, and a composite VLIW instruction execution unit which executes the decoded composite VLIW instruction to perform the operation.
Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations. (1976)

The level, phenotypes, and isozyme distribution of adenosine deaminase (ADA) were determined in lymphocytes from patients with chronic lymphocytic leukemia (CLL). The ADA level in lymphocytes from patients with untreated CLL was consistently lower than in lymphocytes from normal subjects. No significant differences were found in the phenotype or isozyme distribution. In untreated patients, the ADA level was inversely correlated with the lymphocyte count and the percentage of bursa-equivalent (B) cells. After therapy, a diminution in the lymphocyte count was associated with an increase of ADA activity towards normal levels. The ADA levels were slightly higher in the thymus-derived (T) than in the B lymphocytes from normal subjects. The B cells had lower activity than T cells in patients with CLL. They also had a lower activity than the B cells from normal subjects. The ADA level was 2.3-fold higher in T cells from patients with CLL than in normal T cells. The decrease in ADA levels is an anomaly that is reversible and appears to be a reflection of the proliferation of abnormal B cells in this disorder.
Signal-averaged P wave analysis for delineation of interatrial conduction – Further validation of the method (2007)

The methodology used has profound effects on the estimation of P wave duration, and the method used must therefore be validated before any inferences can be made about P wave duration. This has implications in the interpretation of multiple studies where P wave duration is assessed, and conclusions with respect to normal values are drawn.P wave morphology and duration assessed using unfiltered, signal-averaged P wave analysis have high reproducibility, which is unaffected by the length of the recording. In the present study, the performance of the proposed automated classification algorithm, providing total reproducibility, showed excellent agreement with manually defined P wave morphologies.
The secondary α-deuterium isotope effect at the site of the enzyme-catalyzed cis-trans isomerization of maleylacetone. Mechanistic implications (1999)

An equal mixture of monodeuterated isotopomers of maleylacetone, viz., 4-hydroxy-6-oxo-2,4-heptadienoic-2-d 1 acid (1) and 4-hydroxy-6-oxo-2,4-heptadienoic-3-d 1 acid (2) was synthesized and subjected to catalyzed cis-trans isomerization by the maleylacetoacetate cis-trans isomerase-glutathione system. These studies were designed to probe the detailed mechanism of enzyme-catalyzed cis-trans isomerization about the C-2C-3 bond of the substrate. In the competitive reaction, 2 accumulates with respect to 1 at high extent of reaction. 1 H NMR analysis indicates that 1 reacts 15% faster than 2 in line with a nucleophilic addition mechanism at C-2 rather than a conjugate addition mechanism at C-2 and C-3, to convert the C-2C-3 double bond to a single bond to allow facile internal rotation.Key words: enzyme-catalyzed cis-trans isomerization, secondary α-deuterium isotope effect, maleylacetoacetate cis-trans isomerase, cis-trans isomerization mechanism.
Acquisition and data processing considerations in functional metabolic imaging using CEST (2023)

Accelerated acquisitions with a CEST-linescan sequence coupled with the estimation of the local baseline for the analysis of the Z-spectra allow to simultaneously monitor dynamic changes at several CEST contributions induced by a controlled pH decrease. This approach can be a promising strategy for detecting functional induced metabolic changes devoid of confounding BOLD effects.
Computational Communication Science: A Methodological Catalyzer for a Maturing Discipline (2019)

This article reviews the opportunities and challenges for computational research methods in the field of communication. Among the social sciences, communication stands out as a discipline with a relatively low-profile institutionalized focus on the in-house development of methods. Computational tools are changing this, and they are catalyzing a new set of methods directly suited to tackling foundational research questions in communication. We systematically review how computational methods affect the three fundamental pillars of the scientific method: observational approaches (i.e., digital trace data), theoretical approaches (i.e., computer simulations), and experimental research (i.e., virtual labs and field experiments). We stress that data are a catalyzer but not a requirement for computational science. We explore how observational, theoretical, and experimental approaches can be combined and cross-fertilize one another. We conclude that taking advantage of computational methods will require a systematic effort in our discipline to develop and adjust these methods. © 2019 (Martin Hilbert, George Barnett, Joshua Blumenstock, Noshir Contractor, Jana Diesner, Seth Frey, Sandra González-Bailón, PJ Lamberson, Jennifer Pan, Tai-Quan (Winson) Peng, Cuihua (Cindy) Shen, Paul E. Smaldino, Wouter van Atteveldt, Annie Waldherr, Jingwen Zhang, and Jonathan J. H. Zhu).
Ultrasound-assisted preparation of cellulose nanocrystals-sepiolite bionanocomposites (2017)

Oral presentation given at the XVI International Clay Conference, held in Granada (Spain) on July 17-21, 2017.
Very Deep Graph Neural Networks Via Noise Regularisation. (2021)

Graph Neural Networks (GNNs) perform learned message passing over an input graph, but conventional wisdom says performing more than handful of steps makes training difficult and does not yield improved performance. Here we show the contrary. We train a deep GNN with up to 100 message passing steps and achieve several state-of-the-art results on two challenging molecular property prediction benchmarks, Open Catalyst 2020 IS2RE and QM9. Our approach depends crucially on a novel but simple regularisation method, which we call ``Noisy Nodes'', in which we corrupt the input graph with noise and add an auxiliary node autoencoder loss if the task is graph property prediction. Our results show this regularisation method allows the model to monotonically improve in performance with increased message passing steps. Our work opens new opportunities for reaping the benefits of deep neural networks in the space of graph and other structured prediction problems.
Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways (2013)

Is the order in which proteins assemble into complexes important for biological function? Here, we seek to address this by searching for evidence of evolutionary selection for ordered protein complex assembly. First, we experimentally characterize the assembly pathways of several heteromeric complexes and show that they can be simply predicted from their three-dimensional structures. Then, by mapping gene fusion events identified from fully sequenced genomes onto protein complex assembly pathways, we demonstrate evolutionary selection for conservation of assembly order. Furthermore, using structural and high-throughput interaction data, we show that fusion tends to optimize assembly by simplifying protein complex topologies. Finally, we observe protein structural constraints on the gene order of fusion that impact the potential for fusion to affect assembly. Together, these results reveal the intimate relationships among protein assembly, quaternary structure, and evolution and demonstrate on a genome-wide scale the biological importance of ordered assembly pathways.