gebhart/patrepeval huggingface dataset:
[Spontaneous disappearance of a thoracic disc hernia]. (1999)

We report a case of a 55-year-old man who experienced spontaneous resolution of a large herniated disc at T8-9. Spontaneous resolution of disc herniation is well known at the lumbar level. This case is a rare example of a large thoracic disc herniation diagnosed by CT and MRI which completely regressed six months after a medical treatment with complete disappearance of symptoms. The mechanism of resolution of a disc herniation is unclear and we discuss theoretical considerations. We emphasize the interest of conservative therapy in patients with thoracic disc herniation without neurological deficit.
Photonic integrated circuits for Department of Defense-relevant chemical and biological sensing applications: state-of-the-art and future outlooks (2019)

Photonic integrated circuits (PICs), the optical counterpart of traditional electronic integrated circuits, are paving the way toward truly portable and highly accurate biochemical sensors for Department of Defense (DoD)-relevant applications. We introduce the fundamentals of PIC-based biochemical sensing and describe common PIC sensor architectures developed to-date for single-identification and spectroscopic sensor classes. We discuss DoD investments in PIC research and summarize current challenges. We also provide future research directions likely required to realize widespread application of PIC-based biochemical sensors. These research directions include materials research to optimize sensor components for multiplexed sensing; engineering improvements to enhance the practicality of PIC-based devices for field use; and the use of synthetic biology techniques to design new selective receptors for chemical and biological agents.
Soluble CD4 suppresses T-dependent IgG2a antibody response of CD4 loosing mice by inhibiting IFNgamma production. (2001)

To analyze the role of soluble CD4 (sCD4) in antibody (Ab) responses in CD4 loosing (CD4L) mice, experiments have been done in comparing CD4L mice with CD4 knockout (CD4KO) mice on the same C57BL/6 background. The CD4L mice have a defect in CD4 expression where CD4 mRNA is alternatively spliced so that a transmembrane portion is deleted and sCD4 are secreted without expression of membrane-bound CD4. Significantly reduced immunoglobulin (Ig) G2a isotype Ab response against a T-dependent antigen (Ag), trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH), was found in CD4L mice as compared with those of CD4KO mice. Gamma interferon (IFNgamma) production of KLH-stimulated lymph nodes cells was significantly reduced in CD4L mice as compared with those in CD4KO mice. The positive proportion of cells expressing CD40 ligand from CD4KO mice or CD4L mice was much lower than those from wild type mice. There was no difference between CD4KO and CD4L mice in T-cells expressing CD40 ligand after stimulation. Taken together, results in this study indicate that sCD4 suppresses IgG2a Ab responses of CD4L mice by inhibiting IFNgamma production. The mutant mice could provide a good model to analyze the mechanism of IFNgamma involvement in the Ab response against T-dependent Ag.
Topological network alignment uncovers biological function and phylogeny (2010)

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology and disease. Comparison and alignment of biological networks will probably have a similar impact. Existing network alignments use information external to the networks, such as sequence, because no good algorithm for purely topological alignment has yet been devised. In this paper, we present a novel algorithm based solely on network topology, that can be used to align any two networks. We apply it to biological networks to produce by far the most complete topological alignments of biological networks to date. We demonstrate that both species phylogeny and detailed biological function of individual proteins can be extracted from our alignments. Topology-based alignments have the potential to provide a completely new, independent source of phylogenetic information. Our alignment of the protein-protein interaction networks of two very different species-yeast and human-indicate that even distant species share a surprising amount of network topology, suggesting broad similarities in internal cellular wiring across all life on Earth.
ICAS 2012 - Brisbane: Repair Concept supported by Laser Removal and Inductive Heating (2012)

Comprehensive staging after removal of localized OMGCT is crucial. It allows a safe observation strategy in stage Ia tumors. Patients with stages Ix and Ic tumors may benefit from adjuvant chemotherapy.
Synthesis and characterization of the first example of a metallacarborane that incorporates an alkaline-earth metal: the molecular structure of closo-1,1,1,1-(MeCN)4-1,2,4-CaC2B10H12 (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of the first example of a metallacarborane that incorporates an alkaline-earth metal: the molecular structure of closo-1,1,1,1-(MeCN)4-1,2,4-CaC2B10H12Rajesh Khattar, Carolyn B. Knobler, and M. Frederick HawthorneCite this: J. Am. Chem. Soc. 1990, 112, 12, 4962–4963Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ja00168a053https://doi.org/10.1021/ja00168a053research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Efficient Algorithms for Creation of Linearly‐independent Decision Diagrams and their Mapping to Regular Layouts (2000)

A new kind of a decision diagrams are presented: its nodes correspond to all types of nonsingular expansions for groups of input variables, in particular pairs. The diagrams are called the Linearly Independent (LI) Decision Diagrams (LI DDs). There are 840 nonsigular expansions for a pair of variables, thus 840 different types of nodes in the tree. Therefore, the number of nodes in such (exact) diagrams is usually much smaller than the number of nodes in the well‐known Kronecker diagrams (which have only single‐variable Shannon, Positive Davio, and Negative Davio expansions in nodes). It is usually much smaller than 1/3 of the number of nodes in Kronecker diagrams. Similarly to Kronecker diagrams, the LI Diagrams are a starting point to a synthesis of multilevel AND/OR/EXOR circuits with regular structures. Other advantages of LI diagrams include: they generalize the well‐known Pseudo‐Kronecker Functional Decision Diagrams, and can be used to optimize the new type of PLAs called LI PLAs. Importantly, while the known decision diagrams used AND/EXOR or AND/OR bases, the new diagrams are AND/OR/EXOR‐based. Thus, because of a larger design space, multi‐level structures of higher regularity can be created with them. This paper presents both new concepts and new efficient synthesis algorithms.
ChemInform Abstract: A Convenient Synthesis of Pseudoceratidine and Three Analogues for Biological Evaluation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Two-dimensional microscanner for laser projection (2013)

The design of a two-dimensional (2D) microscanner actuated electrostatically is presented, and a silicon-oninsulator (SOI) micromachining process is utilized to fabricate the sample. The microscanner can oscillate at inherent frequencies of 1146 and 360 Hz around two rotational axes, generating maximum twisting angles of 10 and 5.3 under two 10-V square waves, respectively. A monochromatic laser projection system based on Lissajous pattern is demonstrated using the developed microscanner, revealing an image resolution of 16856 at 20 frames per second.
Positron Emission Tomography in the Detection and Management of Sarcomatous Transformation in Neurofibromatosis (2001)

Benign neurofibromas undergo sarcomatous transformation in approximately 5% of patients with neurofibromatosis type I. The clinical and radiologic diagnosis of sarcomatous change remains difficult. Positron emission tomography with F-18 fluorodeoxyglucose is a method to assess increased glucose metabolism in malignant tissue such as sarcomas. In this case report, positron emission tomography accurately distinguished malignant from benign neurofibromas. The technique may be useful as a noninvasive screening tool for malignant transformation of neurofibromas.
The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model (2021)

<b>Background:</b> A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell transfer mouse model to get further insight into the regulation of T cell-mediated immunopathology. <b>Methods:</b> Colitis was induced in severe combined immunodeficient (SCID) mice, by the adoptive transfer of CD4<sup>+</sup>CD25<sup>-</sup>CD62L<sup>+</sup> T cells. Animals were treated intraperitoneally (i.p.) 2x/day with vehicle or UAMC-00050 (5 mg/kg) from week 2 onwards. Colonic inflammation was assessed by clinical parameters, colonoscopy, macroscopy, microscopy, myeloperoxidase activity and cytokine expression levels. At week 4, 4 kDa FITC-dextran intestinal permeability was evaluated and T helper transcription factors, protease-activated receptors and junctional proteins were quantified by RT-qPCR. <b>Results:</b> Adoptive transfer of CD4<sup>+</sup>CD25<sup>-</sup>CD62L<sup>+</sup> T cells resulted in colonic inflammation and an altered intestinal permeability. The serine protease inhibitor UAMC-00050 ameliorated both the inflammatory parameters and the intestinal barrier function. Furthermore, a decrease in colonic mRNA expression of Tbet and PAR4 was observed in colitis mice after UAMC-00050 treatment. <b>Conclusion:</b> The beneficial effect of UAMC-00050 on inflammation was apparent via a reduction of Tbet, IFN-γ, TNF-α, IL-1β and IL-6. Based on these results, we hypothesize a pivotal effect of serine protease inhibition on the Th1 inflammatory profile potentially mediated via PAR4.
Efficient determinization of tagged word lattices using categorial and lexicographic semirings (2011)

Speech and language processing systems routinely face the need to apply finite state operations (e.g., POS tagging) on results from intermediate stages (e.g., ASR output) that are naturally represented in a compact lattice form. Currently, such needs are met by converting the lattices into linear sequences (n-best scoring sequences) before and after applying the finite state operations. In this paper, we eliminate the need for this unnecessary conversion by addressing the problem of picking only the single-best scoring output labels for every input sequence. For this purpose, we define a categorial semiring that allows determinzation over strings and incorporate it into a 〈Tropical, Categorial〉 lexicographic semiring. Through examples and empirical evaluations we show how determinization in this lexicographic semiring produces the desired output. The proposed solution is general in nature and can be applied to multi-tape weighted transducers that arise in many applications.
Influence of Film Additives on Stabilizing Drug Release Rates from Pellets Coated with Acrylic Polymers (2001)

The objective of this study was to investigate the influence of talc and triethyl citrate (TEC) on stabilizing the drug release rates following curing and storage at elevated temperature of pellets coated with an aqueous acrylic polymeric dispersion. Core pellets containing anhydrous theophylline (20%), microcrystalline cellulose, and polyvinylpyrrolidone were prepared by extrusion-spheronization. The aqueous dispersions were prepared by adding up to 30% TEC as a plasticizer and talc up to 200% as an antiadherent to a mixture of Eudragit RS 30D/RL 30D (95:5). The theophylline pellets were coated in a fluidized-bed coating unit and then cured at elevated temperatures. Theophylline pellets were successfully coated with the Eudragit dispersions that contained up to 200% talc, based on the dry polymer weight, and the coating efficiency was greater than 93%. Our results demonstrated that the polymer, which was plasticized by TEC, was able to function as a film-forming agent for dispersions containing high levels of talc. No sticking of the coated pellets was observed during the coating process or during the curing or equilibrating phase, even with high levels of TEC in the film. The dissolution rate of theophylline from the coated pellets was delayed when the film coating dispersion contained high levels of talc. Additionally, the stability of the drug release profiles from the coated pellets after storage was significantly improved. Furthermore, a modified dissolution testing used to simulate mechanical stresses that may be encountered in vivo showed the film coated pellets would have sufficient strength. The results of this study demonstrated that high levels of film additives in the acrylic dispersion contributed to the stabilization of the drug release rates as well as the reproducibility of the coating process.
Expression of Matrix Metalloproteinase in the Fluids of Renal Cystic Lesions (2002)

Our data show that MMPs were detectable in cystic fluids in the presence of renal cystic changes. MMP-2 and 9 are more abundant in cystic carcinoma fluids than in benign cystic fluids. These observations suggest that matriolytic enzymes in renal cystic fluid reflect biological aggressiveness and in part explain the pathogenesis of renal cystic lesions.
Integrated Silicon Nitride Optical Beamforming Networks for Wideband Communications (2018)

Two approaches to ripple free 1 × 4 optical beamforming networks are presented; one is based on a 5-stage Mach-Zehnder switchable delay line and the other on a 3-optical-ring-resonator delay line. Both are demonstrated for W-band communications.
Solution-Processed Organic Solar Cells Based on Dialkylthiol-Substituted Benzodithiophene Unit with Efficiency near 10% (2014)

A small molecule named DR3TSBDT with dialkylthiol-substituted benzo[1,2-b:4,5-b']dithiophene (BDT) as the central unit was designed and synthesized for solution-processed bulk-heterojunction solar cells. A notable power conversion efficiency of 9.95% (certified 9.938%) has been achieved under AM 1.5G irradiation (100 mW cm(-2)), with an average PCE of 9.60% based on 50 devices.
Em polypeptide and its messenger RNA levels are modulated by abscisic acid during embryogenesis in wheat (1985)

The effect of abscisic acid (ABA) on the expression of the 'early-methionine-labeled' (Em) polypeptide was examined in cultured, immature wheat (Triticum aestivum, L.) embryos and in developing embryos in planta. A complementary DNA (cDNA) library was constructed from poly(A)-rich RNA from immature embryos cultured in the presence of ABA. ABA-enhanced sequences were first identified by differential colony-blot hybridization, and then verified using RNA slot-blot analysis. Dot-blot hybridization showed that one clone, p1015, was homologous to the previously isolated Em cDNA, pWG432. Electrophoretic analysis of the hybrid-select translation product of p1015 confirmed its identity as an Em sequence. Comparison of the p1015 cDNA insert size and the Em message size, from northern blot analysis, showed that p1015 contained about 87% of the Em sequence. RNA slot-blot analysis and protein electrophoresis showed that Em message, but not Em protein, accumulated at a low, basal level in immature embryos in the absence of ABA. Neither Em message nor Em protein was seen in three-day germinated seedlings. Steady-state levels of Em message and protein increased in immature embryos in the presence of ABA, both in culture and in planta. Regulation appeared to be primarily at the level of transcription or specific message stability. Regulation may also involve specific protein stability, since synthesis of Em protein continued in immature embryos in the absence of ABA, but Em protein did not accumulate in detectable amounts. We conclude that ABA specifically modulates Em message and protein levels in immature embryos, but is probably not responsible for the embryogenic specificity of Em expression.
Cross-Layer Aided Energy-Efficient Routing Design for Ad Hoc Networks (2015)

In this treatise, we first review some basic routing protocols conceived for ad hoc networks, followed by some design examples of cross-layer operation aided routing protocols. Specifically, cross-layer operation across the PHYsical layer (PHY), the Data Link layer (DL) and even the NETwork layer (NET) is exemplified for improving the energy efficiency of the entire system. Moreover, the philosophy of Opportunistic Routing (OR) is reviewed for the sake of further reducing the system's energy dissipation with the aid of optimized Power Allocation (PA). The system's end-to-end throughput is also considered in the context of a design example.
One Versus all for deep Neural Network Incertitude (OVNNI) quantification (2020)

Deep neural networks (DNNs) are powerful learning models yet their results are not always reliable. This is due to the fact that modern DNNs are usually uncalibrated and we cannot characterize their epistemic uncertainty. In this work, we propose a new technique to quantify the epistemic uncertainty of data easily. This method consists in mixing the predictions of an ensemble of DNNs trained to classify One class vs All the other classes (OVA) with predictions from a standard DNN trained to perform All vs All (AVA) classification. On the one hand, the adjustment provided by the AVA DNN to the score of the base classifiers allows for a more fine-grained inter-class separation. On the other hand, the two types of classifiers enforce mutually their detection of out-of-distribution (OOD) samples, circumventing entirely the requirement of using such samples during training. Our method achieves state of the art performance in quantifying OOD data across multiple datasets and architectures while requiring little hyper-parameter tuning.
Office Diagnosis and Management of Abnormal Uterine Bleeding (2012)

Abnormal uterine bleeding is one of the most common presenting complaints encountered in a gynecologist's office or primary care setting. The availability of diagnostic tools, such as ultrasound, endometrial sampling, and diagnostic hysteroscopy has made it possible to promptly diagnose and treat an increasing number of menstrual disorders in an office setting. The incorporation of newer medical therapies: antifibrinolytic drugs, shorter hormone-free interval oral contraceptive pills, and levonorgestrel inserts along with office minimally invasive treatments operative hysteroscopy and endometrial ablations have proven to be powerful therapeutic arsenals to provide short-term relief of abnormal uterine bleeding, and potentially, avoiding or delaying the hysterectomy.
Demecolcine Effects on Microtubule Kinetics and on Chemically Assisted Enucleation of Bovine Oocytes (2009)

This study aimed to evaluate the effect of demecolcine, a microtubule-depolymerizing agent, on microtubule kinetics; to determine the best concentration of demecolcine as a chemically assisted enucleation agent in metaphase I (MI) and metaphase II (MII) bovine oocytes, and to evaluate the embryonic development after nuclear transfer (NT) using chemically assisted enucleation of recipient oocytes. Oocytes in vitro matured for 12 h (MI) and 21 h (MII) were exposed to several concentrations of demecolcine and evaluated for enucleation or membrane protrusion formation. Demecolcine concentration of 0.05 microg/mL produced the highest rates of enucleation in group MI (15.2%) and protrusion formation in group MII (55.1%), and was employed in the following experiments. Demecolcine effect was seen as early as 0.5 h after treatment, with a significant increase in the frequency of oocytes with complete microtubule depletion in MI (58.9%) and MII (21.8%) compared to initial averages at 0 h (27.4% and 1.9%, respectively). Microtubule repolymerization was observed when MII-treated oocytes were cultured in demecolcine-free medium for 6 h (42.4% oocytes with two evident sets of microtubules). Chemically assisted enucleated oocytes were used as recipient cytoplasts in NT procedures to assess embryonic development. For NT, 219 of 515 oocytes (42.5%) formed protrusions and were enucleated, and reconstructed, resulting in 58 nuclear-transferred one-cell embryos. Cleavage (84.5%) and blastocyst development (27.6%) rates were assessed. In conclusion, demecolcine can be used at lower concentrations than routinely employed, and the chemically assisted enucleation technique was proven to be highly efficient allowing embryonic development in bovine.
Preparation and Characterization of Fluorinated Fullerenes (1993)

Abstract Fluorination of pure C60 and a C60/C70 mixture has been studied under different experimental conditions: reaction time, temperature, fluorine pressure. The products obtained have been characterized by IR and NMR spectroscopy, X-ray diffraction, and mass spectrometry analysis by positive and negative ions.
Joint Sparse Recovery Method for Compressed Sensing With Structured Dictionary Mismatches (2014)

In traditional compressed sensing theory, the dictionary matrix is given a priori, whereas in real applications this matrix suffers from random noise and fluctuations. In this paper, we consider a signal model where each column in the dictionary matrix is affected by a structured noise. This formulation is common in direction-of-arrival (DOA) estimation of off-grid targets, encountered in both radar systems and array processing. We propose to use joint sparse signal recovery to solve the compressed sensing problem with structured dictionary mismatches and also give an analytical performance bound on this joint sparse recovery. We show that, under mild conditions, the reconstruction error of the original sparse signal is bounded by both the sparsity and the noise level in the measurement model. Moreover, we implement fast first-order algorithms to speed up the computing process. Numerical examples demonstrate the good performance of the proposed algorithm and also show that the joint-sparse recovery method yields a better reconstruction result than existing methods. By implementing the joint sparse recovery method, the accuracy and efficiency of DOA estimation are improved in both passive and active sensing cases.