gebhart/patrepeval huggingface dataset:
Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting (2019)

<b>Background:</b> A surgical site infection (SSI) is believed to be the result of an exaggerated inflammatory response. <b>Objective:</b> Examine the relationship between clinical status and inflammation biomarkers in full-thickness skin grafting wounds. <b>Methods:</b> Twenty patients planned for facial full-thickness skin grafting were enrolled. A week after surgery, all graft wounds were clinically assessed using a 3-step scale for inflammation (low, moderate, high). All wounds were swabbed for routine microbiological analysis and assessment of numbers of aerobic bacteria. Tie-over dressings from all patients were collected and used for wound fluid extraction and subsequent analysis of MMPs, cytokines, and NF-κB inducing activity. <b>Results:</b> Wounds with a high degree of inflammation contained increased total MMP activity (<i>P</i> ≤ 0.05) in their corresponding fluids. Likewise, the level of the cytokines IL-1ß, IL-8, IL-6, TNF-α was analyzed, and particularly IL-1ß was discriminatory for highly inflamed wounds (<i>P</i> ≤ 0.01). Moreover, bacterial loads were increased in highly inflamed wounds compared to wounds with a low degree of inflammation (<i>P</i> ≤ 0.01). NF-κB activation in the monocytic cell line THP-1 was significantly higher when these cells were stimulated by wound fluids with a high degree of inflammation (<i>P</i> ≤ 0.01). Growth of <i>S. aureus</i> in wounds did not vary between wounds with different degrees of inflammation (chi-square 3.8, <i>P</i> = 0.144). <b>Conclusion:</b> Biomarkers analyzed from tie-over dressings correlated to clinical wound healing in full-thickness skin grafting.
Multi-Omics of Single Cells: Strategies and Applications (2016)

Most genome-wide assays provide averages across large numbers of cells, but recent technological advances promise to overcome this limitation. Pioneering single-cell assays are now available for genome, epigenome, transcriptome, proteome, and metabolome profiling. Here, we describe how these different dimensions can be combined into multi-omics assays that provide comprehensive profiles of the same cell.
Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis (2012)

The data corroborate a strong correlation between alloreactivity and long-term post-transplant disease control and confirm an inverse relationship between disease stage, pharmacotherapy and outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis. The Dynamic International Prognostic Scoring System was demonstrated to be useful for risk stratification of patients with myelofibrosis who are to undergo hematopoietic stem cell transplantation.
In-line metrology for defect assessment on large area Roll 2 Roll substrates (2014)

This paper reports on the recent work carried out as part of the EU funded research and development project NanoMend. The project seeks to develop integrated process inspection, cleaning, repair for nano-scale thin films on large area substrates. Flexible photovoltaic (PV) films based on CIGS (Copper Indium Gallium Selenide CuInxGa(1-x)Se2) have been reported to have light energy conversion efficiencies as high as 19%. Their adoption has many advantages in terms of applications and in particular building integration. These CIGS based multi-layer flexible devices are fabricated on polymer film by the repeated deposition, and patterning, of thin layer materials using roll-to-roll processes (R2R), where the whole film is approximately 3μm thick prior to final encapsulation. The resultant films are lightweight and flexible however wide scale implementation is hampered by long term environmental degradation of efficiency due to water ingress to the CIGS modules through the polymer layers causing electrical shorts and corresponding efficiency drops. In order to prevent water ingress the PV modules are coated with a protective barrier layer of Al2O3 using atomic layer deposition (ALD) methods. Unfortunately defects in this layer have been shown to reduce efficiency over a period of time due to water vapour passage. The present work concentrates on defect detection and reports on the use of areal surface metrology to correlate defect morphology with water vapour transmission rate (WVTR) through the protective barrier coatings The use of advanced segmentation techniques is demonstrated where topographic information on functionally significant defects can be extracted and quantified. The work also reports on the deployment of new in line interferometric optical sensors designed to measure and catalogue the defect distribution and size where they are present in the 40nm thick barrier film. The sensors have built-in environmental vibration compensation and have been deployed on a demonstrator system at a Roll2Roll production facility.
Ultra-Robust Graphene Based Bio-Nanocomposites and Their Electronic Applications (2016)

This study is focused on the fundamental principles of fabricating polymer nanocomposite materials and optimizing their structural and functional properties. The status of the research on polymer nanocomposites has been critically reviewed and the motivation and challenges to develop ultra-robust, functional nanocomposite films are presented. Biopolymers, such as silk fibroin (SF) and cellulose nanocrystals (CNC), and graphene oxide (GO) are chosen as the model system to investigate the optimized interfacial interactions between biomacromolecules and the heterogeneous, most widely available graphene derivative.&#13;\nTwo different aspects of the polymer nanocomposites were the focus of this study with multiple examples presented: 1) the mechanical enhancement by the synergistic reinforcement between the nanofiller and polymer matrix, and 2) the effective improvement of electrical properties of the graphene oxide component in the nanocomposite for electrical and functional applications. We suggest that the understanding of the integration of biopolymers and graphenes using versatile assembly techniques and the successive chemical modification of the electrical properties of the nanocomposite discussed in this study can be important for tackling the challenges faced by the employment of flexible and robust structural and bio-microelectronic materials.
A Reinforcement Learning Approach to Online Web Systems Auto-configuration (2009)

In a web system, configuration is crucial to the performance and service availability. It is a challenge, not only because of the dynamics of Internet traffic, but also the dynamic virtual machine environment the system tends to be run on. In this paper, we propose a reinforcement learning approach for autonomic configuration and reconfiguration of multi-tier web systems. It is able to adapt performance parameter settings not only to the change of workload, but also to the change of virtual machine configurations. The RL approach is enhanced with an efficient initialization policy to reduce the learning time for online decision. The approach is evaluated using TPC-W benchmark on a three-tier website hosted on a Xen-based virtual machine environment. Experiment results demonstrate that the approach can auto-configure the web system dynamically in response to the change in both workload and VM resource. It can drive the system into a near-optimal configuration setting in less than 25 trial-and-error iterations.
Sampling the 2-D Radon transform (1981)

The Radon transform of a bivariate function, which has application in tomographic imaging, has traditionally been viewed as a parametrized univariate function. In this paper, the Radon transform is instead viewed as a bivariate function and two-dimensional sampling theory is used to address sampling and information content issues. It is Shown that the band region of the Radon transform of a function with a finite space-bandwidth product is a "finite-length bowtie." Because of the special shape of this band region. "Nyquist sampling" of the Radon transform is on a hexagonal grid. This sampling grid requires approximately one-half as many samples as the rectangular grid obtained from the traditional viewpoint. It is also shown that for a nonbandlimited function of finite spatial support, the bandregion of the Radon transform is an "infinite-length bowtie." Consequently, it follows that approximately 2M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /π independent pieces of information about the function can be extracted from M "projections." These results and others follow very naturally from the two-dimensional viewpoint presented.
An improved method to solve a fuzzy linear system in the fuzzy finite element method (2009)

In this paper we present a new method to solve the fuzzy linear system in the Fuzzy Finite Element Method (FFEM).We make use of an approach presented by A. Vroman, G. Deschrijver and E.E.Kerre.[1] to solve general fuzzy linear systems.This method is based on parametric functions and has an exponential time complexity in the number of fuzzy numbers in the fuzzy linear system.By taking the reccurrence of fuzzy variables, sometimes under a different form, in the linear system within the FFEM into account, we can optimize this method depending on the level of reccurrence of those fuzzy variables.The method remains exponentially in time but the exponent depends on the level of reccurrence of the fuzzy variables.The base is greater than the base in the original method, which was 2, because of the loss of monotonicity in the parametric functions, but the cost to construct those parametric functions from the fuzzy linear system is higher in our modified approach.This is compensated by taking the dependencies between the fuzzy numbers into account.Additionally, we suggest some extensions to re-use the solution of one fuzzy linear system matrix to calculate an approximative solution and compare it with the original one.
Computing Through Time: Flying (2020)

Various puzzles, quizzes, games, humorous definitions, or mathematical that should engage the interest of readers.
Treatment of chronic hepatitis C in children and adolescents (2010)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Synthesis of the Azocino[cd]indole Framework through Pd‐Catalyzed Intramolecular Acetylene Hydroarylation (2011)

Abstract The regio‐ and stereoselective construction of the azocino[ cd ]indole core was achieved by applying a Pd‐catalyzed intramolecular acetylene hydroarylation protocol. The applicability of a similar strategy for the synthesis of the azepino[ b ]indole framework is demonstrated.
The chemotherapy of rodent malaria. LII. Response of Plasmodium yoelii ssp. NS to mefloquine and its enantiomers (1995)

A comparison was made between the blood schizontocidal action in mice of racemic mefloquine hydrochloride and the free bases of its (+)- and (-)-enantiomers (Ro 13-7224 and Ro 13-7225) against chloroquine-resistant Plasmodium yoelii ssp. NS. The racemic hydrochloride was two to three times as active against this parasite in mice as either of the enantiomer free bases, which were of similar activity to each other. Under drug selection pressure, the parasites acquired resistance in approximately the same time for each of the three compounds.
Noise performance of HBT as photodetector in analog fiber-optic communication link (1997)

An analog fiber-optic communication link using a heterojunction bipolar transistor (HBT) as photodetector is analyzed regarding its noise performance Experimental results for signal-to-noise ratio and distortion are compared to other state of the art devices as well as commercial ones. The shot noise limited system using the HBT demonstrated S/N in excess of 50 dB and spurious-free dynamic range better than a commercial PIN. Furthermore, compared to other 3- and 2-terminal devices the HBT is potentially the best candidate for future OEIC technology. Experimental results for a new HBT structure, optimized for photonic applications, shows significant improvement in terms of gain and sensitivity.
Evaluation of ablation of thyroid remnants with 1850 MBq iodine-131 in 67 patients with thyroid cancer (2019)

RRA with 1850 MBq is effective by visual diagnosis, about 40% of all intermediate or high-risk DTC patients achieved initial RRA goals by both visual and Tg levels diagnosis.
Extraction of heart rate from functional near-infrared spectroscopy in infants (2014)

Changes in heart rate are a useful physiological measure in infant studies. We present an algorithm for calculating the heart rate (HR) from oxyhemoglobin pulsation in functional near-infrared spectroscopy (fNIRS) signals. The algorithm is applied to data collected from 10 infants, and the HR derived from the fNIRS signals is compared against the HR as calculated by electrocardiography. We show high agreement between the two HR signals for all infants (r > 0.90), and also compare stimulus-related HR responses as measured by the two methods and find good agreement despite high levels of movement in the infants. This algorithm can be used to measure changes in HR in infants participating in fNIRS studies without the need for additional HR sensors.
Simplified Generation Of Distance Images (1994)

Optoelectronic apparatus undergoing development intended to produce digitized images that contain three-dimensional information: brightness of each picture element in digitized image depends on distance from apparatus to corresponding location in scene. Does not contain mechanical scanners. Signal-processing circuitry in this apparatus simpler. Smaller, weighs less, and consumes less power. Potential applications include automated inspection, remote exploration, robotic manipulators, robotic vehicles, and maneuvering and docking systems.
Variable Selectivities of Acyl Coenzyme A:Monoacylglycerophosphate Acyltransferases in Rat Liver (1972)

Abstract The selectivity in vitro of microsomal acyl-CoA:monoacyl-sn-glycerol-3-phosphate acyltransferases was shown to be variable depending upon the incubation conditions. The availability of the phospholipid substrate can play an important role in regulating the observed selectivity of the enzymes giving higher selectivity at lower monoacyl-sn-glycerol-3-phosphate concentrations. Kinetic considerations support an idea that different catalytic sites may be involved when 1-acyl-sn-glycerol-3-phosphate is being acylated with different acyl-CoA's by rat liver microsomes. Thus, when the acylation occurred at very low 1-acyl-GP concentrations, palmitate and arachidonate tended to be excluded, although to a different degree, from the 2-position of diacyl-GP, whereas relatively nonselective acylation occurs at high 1-acyl-GP concentrations.
A 2-factor in which each cycle contains a vertex in a specified stable set (2010)

Let G be a graph with order n, and let k be an integer with 1 ≤ k ≤ n/3. In this article, we show that if σ2(G) ≥ n + k − 1, then for any stable set S ⊆ V (G )w ith|S| = k, there exists a 2-factor with precisely k cycles C1 ,...,C k such that |V (Ci) ∩ S| =1f or all 1≤ i ≤ k and at most one of the cycles Ci has length strictly greater than three. The lower bound on σ2 is best possible.
Implementation of a robust feedforward neural network using the classifier structure (2002)

In this paper, we improve the performance of a feedforward neural network (FNN) through eliminating the effect of gross error by using the classifier structure. We first prove that the output of a classifier just prior to winner-take-all (WTA) represents the empirical posteriori probability, f/sub 0/(/spl theta//sub i.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome. (2015)

Taken together, the literature would suggest that the borders between different medical domains should be reconsidered in the light of common processes linking them.
Epidemiologic risk factors for patients admitted with chronic pancreatitis and pancreatic ductal adenocarcinoma in the United States (2022)

Based on this large, nationwide analysis, black men between 40-59 years old and overweight are at significantly increased risk for admission with CP. White men older than 40 years old and overweight with higher income were found to have significant associations with CP and PDAC. This discrepancy may reflect underlying differences in healthcare access and utilization among different socioeconomic and ethno-racial groups.
Using source-to-source compilation to instrument circuits for debug with High Level Synthesis (2015)

C-based High Level Synthesis (HLS)-compatible circuit descriptions from the CHStone benchmark suite are instrumented for debugging purposes using a source-to-source compiler. The debug instrumentation connects C expressions to top-level ports that can be observed during the debugging process. Approximately 50,000 different experiments are conducted to determine the impact on the final circuit caused by the debug instrumentation. Experimental data indicate initial feasibility of the instrumentation approach; all assignment expressions in a program can be instrumented for an average increase in LUT count of about 24%. Increases in FF count and clock period were in the range of 5% to 10%.
Tepotinib Efficacy in a Patient with Non-Small Cell Lung Cancer with Brain Metastasis Harboring an HLA-DRB1-MET Gene Fusion (2020)

Alterations in c-MET, a tyrosine kinase receptor encoded by the MET gene, have been reported in approximately 3% of non-small cell lung cancer (NSCLC) cases and carry important treatment implications. The best studied genetic alterations are exon 14 skipping and gene amplification; however, gene rearrangement has also been described, and multiple fusion partners have been reported. Recently, in METex14-mutated NSCLC, multitarget tyrosine kinase inhibitors (TKIs), such as crizotinib and cabozantinib, as well as MET-selective TKIs, such as tepotinib and capmatinib, have demonstrated durable responses. In this study, we present the case of a 41-year-old woman with advanced NSCLC harboring an HLA-DRB1-MET gene fusion. The patient was offered successively two different MET multikinase inhibitors, crizotinib and cabozantinib, and the selective inhibitor tepotinib. Each time, including under tepotinib, the patient experienced rapid and complete responses associated with a tremendous improvement in her physical function. KEY POINTS: To our knowledge, this is the first report of a patient with non-small cell lung cancer harboring an HLA-DRB1-MET gene fusion demonstrating a clinical response to multiple MET inhibitors, including tepotinib. This finding illustrates the efficacy and rationale to targeting MET regardless of fusion partner and gives insight to pooling of patients with different MET fusion products in trials assessing safety and efficacy of novel molecules.
Study of the Plasma Membrane Proteome Dynamics Reveals Novel Targets of the Nitrogen Regulation in Yeast (2017)

Yeast cells, to be able to grow on a wide variety of nitrogen sources, regulate the set of nitrogen transporters present at their plasma membrane. Such regulation relies on both transcriptional and post-translational events. Although microarray studies have identified most nitrogen-sensitive genes, nitrogen-induced post-translational regulation has only been studied for very few proteins among which the general amino acid permease Gap1. Adding a preferred nitrogen source to proline-grown cells triggers Gap1 endocytosis and vacuolar degradation in an Rsp5-Bul1/2-dependent manner. Here, we used a proteomic approach to follow the dynamics of the plasma membrane proteome after addition of a preferred nitrogen source. We identified new targets of the nitrogen regulation and four transporters of poor nitrogen sources-Put4, Opt2, Dal5, and Ptr2-that rapidly decrease in abundance. Although the kinetics is different for each transporter, we found that three of them-Put4, Dal5, and Ptr2-are endocytosed, like Gap1, in an Rsp5-dependent manner and degraded in the vacuole. Finally, we showed that Gap1 stabilization at the plasma membrane, through deletion of Bul proteins, regulates the abundance of Put4, Dal5 and Ptr2.
Immunoreactivity of Monoclonal Antibody BW835 Represents a Marker of Progression and Prognosis in Early Gastric Cancer (2001)

The Thomsen-Friedenreich (TF) antigen is a well-known human pan-carcinoma antigen. It represents a carbohydrate core disaccharide (Gal beta 1-3GalNAc) which is predominantly bound to mucin peptide cores. Its immunoreactivity depends on changes in glycosylation which lead to a reduction in the carbohydrate chain length and the exposure of core carbohydrates. In the present study, we investigated 208 gastric adenocarcinomas with respect to their immunohistochemical reactivity applying two monoclonal antibodies (MAbs). MAb specifically detecting TF antigen (A78-G/A7) and MAb BW835 were included. The latter reacts with a certain glycoform of the MUC1 peptide core, characterized by core-type glycans like TF. A78-G/A7 epitopes were detected in 68.8% and BW835 epitopes in 57.7% of the carcinomas. BW835 immunoreactivity correlated with the presence of lymph node metastases. Both A78-G/A7 and BW835 staining were significantly stronger in tubular/papillary cancer (WHO classification) and intestinal-type cancer according to Laurén. In univariate survival analyses of all patients studied, BW835 immunoreactivity was a marker of an unfavorable prognosis (p < 0.05). The presence of A78-G/A7 and BW835 epitopes exerted a negative effect on the subgroup of pTNM stage I carcinomas. These results indicate that TF and MUC1-TF immunoreactivity defines a 'high-risk' subgroup of stage I patients in gastric cancer.
<title>Signal Processing Applications Of Fiber-Optic Delay Lines</title> (1979)

In recent years, considerable progress has been made in the development of components for wideband optical communication, using glass fibers as the transmission medium. (I&quot;) The most dramatic advance has been in the loss in the fibers themselAes, which has dropped from a minimum of about 1000 dB/km prior to 1970 to 0.2 dB/km today.(&apos;) Similarly, research in the field of integrated optics has led to the development of miniaturized, single-mode com-ponents for use with laser sources. Generation, modulation, directional coupling, switching, and detection of light are functions which have already been demonstrated with integrated optics devices.(&apos;-&apos;) Improvements in bandwidth, switching and multiplexing capability, size, and reliability for fiber communications systems could result from these efforts.