gebhart/patrepeval huggingface dataset:
Mechanical Properties of Functionalized Single‐Walled Carbon‐Nanotube/Poly(vinyl alcohol) Nanocomposites (2005)

Abstract Nanocomposites based on semi‐crystalline poly(vinyl alcohol) (PVA) and well‐dispersed chemically functionalized single‐walled carbon nanotubes are combined through simple mixing. The interaction between the nanotubes and the polymer matrix is studied using optical and thermal methods. Significant enhancement of the mechanical properties is obtained for the functionalized‐nanotube‐based composites. These results imply that promoting nanotube dispersion and strong interfacial bonding through adequate functionalization of nanotubes improves the load transfer from the matrix to the reinforcing phase.
A technológiai közösségi finanszírozás trendjei (2017)

A pénzügyi piacokon a közösségi finanszírozás (crowdfunding) a digitális transzformáció egyik dinamikusan fejlődő területe. Innovatív ötletek és korai fázisú vállalkozások számára nyújt alternatív forrásgyűjtési lehetőséget – tömegek megszólításával – internetes platformokon keresztül többféle üzleti modell szerint. Empirikus kutatásunkhoz azért választottuk a Kickstartert, mert az egyik legismertebb nemzetközi jutalomalapú crowdfunding platform, ahol az ötletgazdák a virtuális térben szűkebb és tágabb közösségektől gyűjthetnek pénzt saját projektjeik megvalósításához. A támogatóktól kapott összegnek el kell érnie egy minimumot ahhoz, hogy a platform az ötletgazda számára átutalja a pénzt. A sikeres kampány után a projektgazda kötelessége, hogy az összegyűjtött forrásból létrehozott termékeket a támogatók számára postai vagy egyéb úton eljuttassa. A hazai és nemzetközi crowdfunding-szakirodalom fontosabb elméleti kereteinek felvázolása után a cikk a Kickstarter platform technológiai projektjeinek trendjeit tekinti át. A sikeres technológiai kampányok átlagos mérete a legnagyobb az összes kategóriához képest, a projektgazdák földrajzi eloszlását tekintve domináns az amerikai és angol kampánykezdeményezők jelenléte. A sikeres kampányok átlagos túlfinanszírozottságának mértéke az USA-ból indított kampányok esetén a legmagasabb. A kampányok lejáratában április–májusban és július–augusztusban láthatók erőteljesebb csúcsok. Számos külföldi kutatás is alátámasztja, hogy a sikeres kampányok esetén magasabb a frissítések száma. A technológiakategórián belül a projektgazdák 80 százaléka csupán egyetlen kampányt indított a platformon.
Uncoupled Endothelial Nitric Oxide Synthase and Oxidative Stress in a Rat Model of Pregnancy-Induced Hypertension (2007)

These data suggest that increased superoxide production by NADPH oxidase, peroxynitrite degradation of BH4, and uncoupled eNOS contribute to endothelial dysfunction in a rat model of pregnancy-induced hypertension.
Position-based vs energy-based motion processing (2016)

It is generally presumed that the perceived motion direction of an object is based on some integration of local motion signals extracted from energy-based motion detectors. However, objects are often perceived as moving in their veridical direction even when the direction of the mean local motion signal diverges from the veridical motion direction. Such percepts have been taken as evidence of complex motion integration of local motion signals to compute the veridical motion direction of objects. An alternative hypothesis is that the perceived direction of a moving object is not based on local motion signals at all, but rather based on tracking the position of the object. We evaluated the perceived motion direction of objects when the direction of the mean local motion signal diverged from the veridical motion direction (reverse-phi, furrow illusion and other stimuli). Energy-based processing of local motion signals and position-based tracking of the objects were each neutralized (or not) by manipulating inter-stimuli intervals (Smith, 1994) and crowding (Allard & Faubert, 2013), respectively. When both motion systems were neutralized, no motion direction was perceived. When only position-based tracking was neutralized, motion was perceived in the direction of the mean local motion signal, which suggests a simple integration (i.e., averaging) of local motion signals. When position-based tracking was not neutralized, objects were perceived as moving in their veridical direction whether energy-based motion processing was neutralized or not, which suggests that the perceived motion direction was determined by position-based tracking. We conclude that when position-based tracking of objects can operate efficiently, this strategy dominates and motion perception is not based on some integration of local (energy-based) motion signals. There is no need for complex integration of local motion signals to compute the veridical motion direction of objects. Meeting abstract presented at VSS 2016
Pyridonecarboxylic Acids as Antibacterial Agents. IX. Synthesis and Structure-Activity Relationship of 3-Substituted 10-(1-Aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acids and Their 1-Thio and 1-Aza Analogues. (1994)

A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3 -de]-1,4-benzoxazine-6-carboxylic acid and its 1-thio and 1-aza variants. Compound (S)-1, which proved most active in vitro against five representative gram-positive and gram-negative organisms, was assayed in vivo using Staphylococcus aureus and Pseudomonas aeruginosa mouse infection models. It exhibited an excellent in vivo efficacy, being superior to ofloxacin and ciprofloxacin, and was then assayed for convulsion-inducing activity, mammalian cell cytotoxicity, and topoisomerase II inhibition. The biological results showed that (S)-1 displayed antibacterial and toxicological advantages over ofloxacin and ciprofloxacin. Compound (S)-1 and its methanesulfonate showed high serum concentrations after oral and intravenous administrations to mice.
Chemically induced self-assembly of spherical and anisotropic inorganic nanocrystals (2011)

The self-assembly of inorganic nanoparticles is a research area of great interest aiming at the fabrication of unique mesostructured materials with intrinsic properties. Although many assembly strategies have been reported over the years, chemically induced self-assembly remains one of the dominant approaches to achieve a high level of nanoparticle organization. In this feature article we will review the latest developments in assembly driven by the active manipulation of nanoparticle surfaces.
Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: Evidence for interaction at the diltiazem-binding site (1992)

Bis(benzylisoquinoline) alkaloids block Ca2+ uptake through the L-type Ca2+ channel and modulate binding of ligands to four distinct sites (dihydropyridine, benzothiazepine, aralkylamine, and (diphenylbutyl)piperidine) in the Ca2+ entry blocker receptor complex of the channel. These alkaloids are structural analogs of tetrandrine, which has previously been demonstrated to block the L-type Ca2+ channel through interaction at the benzothiazepine (diltiazem) site (King et al., 1988). Different alkaloid conformational classes display either alpha-beta, beta-alpha, alpha-alpha, or beta-beta stereochemistry at the two chiral isoquinoline carbons. Compounds from all four classes were tested for their ability to interact with Ca2+ entry blocker ligands. All analogs completely inhibit diltiazem binding, but many only partially inhibit D-600 and fluspirilene binding. For dihydropyridine binding, the compounds show either stimulation or inhibition or exhibit no effect. This profile is quite different from the interaction displayed by diltiazem or tetrandrine. Scatchard analyses show effects predominantly on Kd for diltiazem, D-600, and PN200-110 binding. Representative conformers do not effect diltiazem dissociation rates but alter dissociation kinetics of ligands which bind to the other three sites. A correlation of the ability of these compounds to inhibit Ca2+ uptake through the L-type Ca2+ channel in GH3 cells exists only with their inhibition of diltiazem binding but not with inhibition of binding of ligands representing other classes of Ca2+ entry blockers. These data, taken together, indicate that a variety of bis(benzylisoquinoline) congeners act to block the L-type Ca2+ channel by binding to the benzothiazepine site on the channel.(ABSTRACT TRUNCATED AT 250 WORDS)
Ultrasensitive and Reversible Nanoplatform of Urinary Exosomes for Prostate Cancer Diagnosis (2019)

Prostate cancer cell-derived exosomes in urine have been extensively studied recently and regarded as novel biomarkers for cancer diagnosis and prognosis, which presents wide prospects in clinical applications. Sensitive detection and specific capture methods are essential for exosomes analysis. Herein, a dual functional platform composed of superparamagnetic conjunctions and molecular beacons (SMC-MB) is reported. The SMC-MB platform is designed based on aptamer immunoaffinity with ultrasensitive detection efficiency and reversible isolation capacity, which, respectively, profit from nonenzymatic amplification methods and magnetic separation along with restriction cleavage. It is noteworthy that exosomes quantification was exactly amplified and transformed into single strand DNA detection. Correlated measurements evidence that the limit of detection of SMC-MB is as low as ∼100 particles/μL in urine, and a linear relationship meets between the logarithmic concentration of exosomes and fluorescence intensity of the molecular beacon. Furthermore, employing prostate specific membrane antigen (PSMA) aptamer, the platform adapted to detect and capture PMSA-positive exosomes from urine samples provides excellent diagnostic efficiency for prostate cancer (PCa). The expression of typical biomarkers of PCa, i.e., PSA and PCA3 mRNA, is significantly higher in PSMA-positive exosomes. Altogether, the platform and strategy described in this paper are promising in urinary exosomes analysis and prostate cancer detection.
Focal spot imaging based on zero lag cross‐correlation amplitude fields: Application to dense array data at the San Jacinto fault zone (2016)

Abstract We image the subsurface below a dense seismic array straddling the Clark branch of the San Jacinto fault zone in Southern California. The analysis is based on focal spots of surface waves associated with the zero lag amplitudes of noise cross‐correlations computed between all stations of the dense array. Local medium properties are inferred from the spatially variable focal spot size and shape based on the first zero crossing of amplitude versus distance distributions. The method provides simultaneous estimates of wave speed, apparent attenuation, and anisotropy without solving a tomographic inverse problem. The obtained images of the frequency dependent seismic velocity distributions are consistent with independent estimates from a far‐field Rayleigh wave tomography. We observe an anticorrelation between our apparent attenuation coefficient and seismic velocity, and a fault‐parallel alignment of fast propagation directions with greater structural complexity to the southwest of the fault. The results imply a complex fault zone structure including a waveguide to the northeast of the fault that is continuous across the observed depth range and a low‐velocity structure to the southwest associated with a shallow sedimentary basin.
prtH in Tannerella forsythensis Is Not Associated With Periodontitis (2006)

On the basis of our data, we conclude that the presence of prtH in T. forsythensis is not discriminative for patients with T. forsythensis-associated periodontitis compared to healthy carriers of T. forsythensis. In addition, the use of whole subgingival plaque samples to test for the prevalence of prtH in bacteria appeared unreliable. Culture of the microorganism is an important condition to receive a sufficient amount of template DNA to detect the specific locus of the genome.
Laparoscopic appendectomy in 625 cases: from innovation to routine. (1991)

Invented in 1982 by Semm, a gynecologist, laparoscopic appendectomy began to be used in operative surgery in 1987. Since then, we have modified and performed this promising procedure in > 700 patients. The data of the first 625 cases indicate that laparoscopic appendectomy is safe and practicable. With regard to patient age as well as the acuteness of the inflammation, the patients represent a cross section of the normal appendicitis population. The major benefits and possible problems of the method are presented and discussed.
Anatomically constrained CT image translation for heterogeneous blood vessel segmentation (2022)

Anatomical structures such as blood vessels in contrast-enhanced CT (ceCT) images can be challenging to segment due to the variability in contrast medium diffusion. The combined use of ceCT and contrast-free (CT) CT images can improve the segmentation performances, but at the cost of a double radiation exposure. To limit the radiation dose, generative models could be used to synthesize one modality, instead of acquiring it. The CycleGAN approach has recently attracted particular attention because it alleviates the need for paired data that are difficult to obtain. Despite the great performances demonstrated in the literature, limitations still remain when dealing with 3D volumes generated slice by slice from unpaired datasets with different fields of view. We present an extension of CycleGAN to generate high fidelity images, with good structural consistency, in this context. We leverage anatomical constraints and automatic region of interest selection by adapting the Self-Supervised Body Regressor. These constraints enforce anatomical consistency and allow feeding anatomically-paired input images to the algorithm. Results show qualitative and quantitative improvements, compared to stateof-the-art methods, on the translation task between ceCT and CT images (and vice versa).
An evaluation of selected DNA extraction strategies for short tandem repeat typing (1997)

Organic and Chelex extraction methods are compared to five commercially available DNA extraction kits. For forensic purposes, comparison of different extraction strategies is based on the ability of the methods to economically recover high yields of amplifiable DNA from small blood samples in a quick, simple and safe manner. The findings of this study indicate that resin-based methods, such as Chelex, are best able to meet these criteria.
Visual Recognition with Deep Learning from Biased Image Datasets. (2021)

In practice, and more especially when training deep neural networks, visual recognition rules are often learned based on various sources of information. On the other hand, the recent deployment of facial recognition systems with uneven predictive performances on different population segments highlights the representativeness issues possibly induced by a naive aggregation of image datasets. Indeed, sampling bias does not vanish simply by considering larger datasets, and ignoring its impact may completely jeopardize the generalization capacity of the learned prediction rules. In this paper, we show how biasing models, originally introduced for nonparametric estimation in (Gill et al., 1988), and recently revisited from the perspective of statistical learning theory in (Laforgue and Clemencon, 2019), can be applied to remedy these problems in the context of visual recognition. Based on the (approximate) knowledge of the biasing mechanisms at work, our approach consists in reweighting the observations, so as to form a nearly debiased estimator of the target distribution. One key condition for our method to be theoretically valid is that the supports of the distributions generating the biased datasets at disposal must overlap, and cover the support of the target distribution. In order to meet this requirement in practice, we propose to use a low dimensional image representation, shared across the image databases. Finally, we provide numerical experiments highlighting the relevance of our approach whenever the biasing functions are appropriately chosen.
Nano‐sized fluorescent particles as new tracers for sentinel node detection: Experimental model for decision of appropriate size and wavelength (2005)

The concepts of made‐to‐order and low‐invasiveness medicines are becoming widely accepted. A treatment for cancer, with minimum invasive surgery and without lymph nodes dissection based on sentinel lymph node (SN) navigation surgery, would adhere to these concepts. Dyes and/or radioisotopes are employed for SN detection in standard methods, however, each detection method has advantages and disadvantages. To make up for the disadvantages, we aimed at developing a new non‐invasive method using fluorescent beads of uniform nano‐size that could efficiently visualize SN from outside the body, and conducted experiments to determine the appropriate size and fluorescent wavelength. We examined various bead sizes and fluorescent wavelengths. The sizes were 20, 40, 100 and 200 nm. The fluorescent peak wavelengths of the beads were yellow‐green (515 nm), dark red (680 nm), far red (720 nm) and infrared (755 nm). The beads were subcutaneously injected into the foot pad of the hind leg of a rat, and followed by laser scanning of the inguinal area for fluorescence observation. The beads exhibited different times for the fluorescence detection according to their sizes and wavelength. The 40 nm beads were considered to be the most appropriate size for SN detection in rats. The wavelength of near infrared was effective for avoiding attenuation by the tissue. In conclusion, we confirmed that uniformly nano‐sized fluorescent beads have the potential to be an alternative to existing tracers in the detection of the SN in animal experiments if we select the appropriate particle size and wavelength. ( Cancer Sci 2005; 96: 353–356)
Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience (2021)

Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis.
Three Separated Growth Sequences of Vertically-Aligned Carbon Nanotubes on Porous Silicon: Field Emission Applications (2018)

Three separated growth sequences of vertically-aligned carbon nanotubes (CNTs) were successfully synthesized for the first time on porous silicon (PSi) by modifying the catalyst-nanotemplate interaction in a two-stage hot filament assisted chemical vapor deposition. The morphological differences between the aligned CNTs grown by various flow rates were investigated by means of FESEM images. The presence of single-wall CNTs (SWCNTs) was confirmed by Raman radial breathing mode peak between 100 and 400 cm-1. The low operating electrical field of the multilayer VACNTs grown on PSi is attributable to a relatively high field enhancement factor, which is the result of the geometrical configuration of the CNTs and the substrate. The findings demonstrate that multilayer CNTs have been identified as promising candidates for field emitters in numerous applications such as electron microscopy, flat panel display, as well as other advanced technologies.
Biting Off Safely More Than You Can Chew: Predictive Analytics for Resource Over-Commit in IaaS Cloud (2012)

Cloud service providers are constantly looking for ways to increase revenue and reduce costs either by reducing capacity requirements or by supporting more users without adding capacity. Over-commit of physical resources, without adding more capacity, is one such approach. Workloads that tend to be 'peaky' are especially attractive targets for over-commit since only occasionally such workloads use all the system resources that they are entitled to. Online identification of candidate workloads and quantification of risks are two key issues associated with over-committing resources. In this paper, to estimate the risks associated with over-commit, we describe a mechanism based on the statistical analysis of the aggregate resource usage behavior of a group of workloads. Using CPU usage data collected from an internal private Cloud, we show that our proposed approach is effective and practical.
The Cluster Transfer Function of AtNEET Supports the Ferredoxin–Thioredoxin Network of Plant Cells (2022)

NEET proteins are conserved 2Fe-2S proteins that regulate the levels of iron and reactive oxygen species in plant and mammalian cells. Previous studies of seedlings with constitutive expression of AtNEET, or its dominant-negative variant H89C (impaired in 2Fe-2S cluster transfer), revealed that disrupting AtNEET function causes oxidative stress, chloroplast iron overload, activation of iron-deficiency responses, and cell death. Because disrupting AtNEET function is deleterious to plants, we developed an inducible expression system to study AtNEET function in mature plants using a time-course proteomics approach. Here, we report that the suppression of AtNEET cluster transfer function results in drastic changes in the expression of different members of the ferredoxin (Fd), Fd-thioredoxin (TRX) reductase (FTR), and TRX network of Arabidopsis, as well as in cytosolic cluster assembly proteins. In addition, the expression of Yellow Stripe-Like 6 (YSL6), involved in iron export from chloroplasts was elevated. Taken together, our findings reveal new roles for AtNEET in supporting the Fd-TFR-TRX network of plants, iron mobilization from the chloroplast, and cytosolic 2Fe-2S cluster assembly. In addition, we show that the AtNEET function is linked to the expression of glutathione peroxidases (GPXs), which play a key role in the regulation of ferroptosis and redox balance in different organisms.
Ultrafast Detection of TeraHertz Radiation with Miniaturized Optomechanical Resonator Driven by Dielectric Driving Force (2022)

We report on an optomechanical terahertz (THz) meta-atom detector empowered by a dielectric driving force scheme. The meta-atom consists of a suspended half-wavelength THz antenna that sustains high quality factor mechanical modes. The THz radiation is resonantly absorbed by the meta-atom and enforces an optimized photothermal mechanism that produces mechanical oscillations, with a responsivity of 30 pm·nW–1/3 Hz·nW–1 in terms of amplitude/frequency response. Moreover, in this optomechanical system, THz-induced Duffing nonlinearities can be easily observed. The dielectric driving forces allow the implementation of a frequency phase-lock loop, with a harmonic bandwidth on the order of 1 MHz, and thus, square wave THz signals can be temporally recovered at frequencies up to 100 kHz.
Use of CD200 blockade inhibitor to enhance glioma immunotherapy (2015)

Meeting abstracts Utilizing tumors as a source of vaccine antigens in immunotherapy has demonstrated promising results. However, to date, researchers have failed to overcome the complex interplay between the tumor and its surrounding microenvironment resulting in T cell tolerance. The progression
An Architectural Modeler and Its Incorporation into the Design 4D program (1990)

Abstract : A common user complaint about computer-assisted design (CAD) programs is that the software is marketed as a design tool but does not help significantly in the building design process, which is a decision making activity. Design 4D is an architectural modeler that user 3D geometry and a seamless database manager to address the needs of Schematic Design. The user interface of Design 4D provides the architect with several new capabilities: to sketch in perspective, to alternate between two- and three-dimensional views, and to use a varied set of layout tools that work equally well when oriented to any axis. This manuscript gives an overview of the three-dimensional interface, the display manipulation within Design 4D, and the modeling implementation developed for this study. Also examined are the geometric database and additional modeling data structures used by Design 4D. (kr)