gebhart/patrepeval huggingface dataset:
Rescue of α-SNS Sodium Channel Expression in Small Dorsal Root Ganglion Neurons After Axotomy by Nerve Growth Factor In Vivo (1998)

Small (18-25 microm diam) dorsal root ganglion (DRG) neurons are known to express high levels of tetrodotoxin-resistant (TTX-R) sodium current and the mRNA for the alpha-SNS sodium channel, which encodes a TTX-R channel when expressed in oocytes. These neurons also preferentially express the high affinity receptor for nerve growth factor (NGF), TrkA. Levels of TTX-R sodium current and of alpha-SNS mRNA are reduced in these cells after axotomy. To determine whether NGF participates in the regulation of TTX-R current and alpha-SNS mRNA in small DRG neurons in vivo, we axotomized small lumbar DRG neurons by sciatic nerve transection and administered NGF or Ringer solution to the proximal nerve stump using osmotic pumps. Ten to 12 days after pump implant, whole cell patch-clamp recording demonstrated that TTX-R current density was decreased in Ringer-treated axotomized neurons (154 +/- 45 pA/pF; mean +/- SE) compared with nonaxotomized control neurons (865 +/- 123 pA/pF) and was restored partially toward control levels in NGF-treated axotomized neurons (465 +/- 78 pA/pF). The V1/2 for steady-state activation and inactivation of TTX-R currents were similar in control, Ringer- and NGF-treated axotomized neurons. Reverse transcription polymerase chain reaction revealed an upregulation of alpha-SNS mRNA levels in NGF-treated compared with Ringer-treated axotomized DRG. In situ hybridization showed that alpha-SNS mRNA levels were decreased significantly in small Ringer-treated axotomized DRG neurons in vivo and also in small DRG neurons that were dissociated and maintained in vitro, so as to correspond to the patch-clamp conditions. NGF-treated axotomized neurons had a significant increase in alpha-SNS mRNA expression, compared with Ringer-treated axotomized cells. These results show that the administration of exogenous NGF in vivo, to the proximal nerve stump of the transected sciatic nerve, results in an upregulation of TTX-R sodium current and of alpha-SNS mRNA levels in small DRG neurons. Retrogradely transported NGF thus appears to participate in the control of excitability in these cells via actions that include the regulation of sodium channel gene expression in vivo.
A Comparative Study of Double-Tract Reconstruction and Roux-en-Y After Gastrectomy for Gastric Cancer (2019)

DT reconstruction is comparable with RY after gastrectomy in safety, surgical outcomes including reflux symptom and postoperative recovery and shows better food intake and body weight maintenance.
Adaptive multi-model monitoring of recurrent mobility patterns (2019)

Multi-model event-triggering is a highly promising technique for efficient monitoring of processes where instead of continuous or even periodic triggering of events, communication and control is only applied after some event interrupt. In this work we investigate an adaptive multi-model monitoring technique whereby a local host that switches between the observed models informs remote hosts of these events which in turn adapt their predictions to reduce prediction error and minimize unnecessary triggering events and future model switching, thereby reducing energy consumption and communication bandwidth. The adaptive technique is examined under a real public transport bus service scenario, where local and remote hosts use a set of mobility models to track travel times and update their arrival schedules according to detected deviations, i.e., event interrupts.
Analytical method for predicting the air-gap flux density of Dual-Rotor Permanent-Magnet (DRPM) Machine (2012)

In this paper an analytical method for designing DRPM machine is presented. As well known, DRPM machine has high efficiency, high torque density and can be used as Electric Vehicle Drive and so on, thus developing a simple and accurate analytical method is necessary. The aim of this paper is to calculate the air-gap flux density taking into account the harmonics of the winding current, the winding type and the influence of radial and parallel magnetized magnets. A magnetic equivalent circuit of DRPM machine is developed, and both inner and outer magnet circuits are analyzed separately. Compared with finite-element method (FEM), the analytical method gets an accurate result.
Enabling multiple accelerator acceleration for Java/OpenMP (2011)

Abstract—While using a single GPU is fairly easy, using multiple CPUs and GPUs potentially distributed over multiple machines is hard because data needs to be kept consistent using message exchange and the load needs to be balanced. We propose (1) an array package that provides partitioned and replicated arrays and (2) a compute-device library to abstract from GPUs and CPUs and their location. Our system automatically distributes a parallel-for loop in data-parallel fashion over all the devices. There are three contributions in this paper. First, we provide transparent use of multiple distributed GPUs and CPUs from within Java/OpenMP. Second, we partition arrays according to the compute-devices ’ relative performance that is computed from the execution time of a small micro benchmark and a series of small bandwidth tests run at program start. Third, we repartition the arrays dynamically at run-time by increasing or decreasing the number of machines used and by switching from CPUs-only to GPUs-only, to combinations of CPUs and GPUs, and back. With our dynamic device switching we minimize communication while maximizing device use. Our system automatically finds the optimal device sets and achieves a speedup of 5 – 200 on a cluster of 8 machines with 2 GPUs each. Keywords-Parallel computing, Java, GpGPU, OpenMP
Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells (2018)

Mast cells (MC) accumulate in colorectal cancer (CRC) and the relationship between MC density and cancer progression has been well recognized. MC can be either pro-tumor or anti-tumor players, depending on the local factors present in the tumor microenvironment. Upon malignant transformation, cancer cells express high levels of sialic acids on cell membrane or by secretion. Siglecs are a family of immunoglobulin-like receptors that bind sialic acids and each subtype has a distinct pattern of expression on immune cells. Among them, Siglec-6 is expressed predominately by MC. However, the function of Siglec-6 in MC is largely unexplored and whether it is expressed by CRC-associated MC remains unknown. In this study, we explored the function of Siglec-6 in CD34<sup>+</sup> derived human MC. MC activation was initiated by IgE crosslinking with or without preincubation of anti-Siglec-6 Ab. Siglec-6 engagement significantly attenuated IgE-dependent MC degranulation as measured by ß-hexosaminidase release and CD63 expression. Interestingly, the production of GM-CSF was also shown reduced upon Siglec-6 engagement. To mimic the milieu of CRC, we cultured primary human MC with colon cancer cells or under hypoxia and Siglec-6 was then measured on these conditioned MC. Coculture with colon cancer cells (HT29 and Caco2) induced upregulation of Siglec-6 on MC. In comparison, normal colon cells (CCD841) had no effect. Also, a time-dependent increase of Siglec-6 by MC was observed under 1% O<sub>2</sub>. Immunohistochemistry of CRC tissue showed expression of Siglec-6 by MC in submucosa. Lectin immunochemistry revealed the presence of actual ligands for Siglec-6 in human CRC tissues. Together, our findings illustrate that Siglec-6 is a functionally inhibitory receptor on MC and suggest that Siglec-6 expression may be relevant for MC activity in the tumor microenvironment of CRC.
Drug therapy in pregnancy: The lessons of diethylstilbestrol, thalidomide, and Bendectin (1990)

A pregnant woman and the fetus she carries face health risks from many sources. One risk that requires ongoing vigilance is the use of prescription drugs during pregnancy. The international health care community has been sensitized to the risks of drug use during pregnancy because of three pharmaceuticals that have caused widespread crises for mothers and their offspring. The crises that diethylstilbestrol, thalidomide, and, to a lesser extent, Bendectin have created in the past four decades are reviewed in this article. The lessons these drug crises can teach us are articulated in the belief that similar crises may be averted in the future.
Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells (2020)

Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes, fibroblasts, melanocytes, and inflammatory cells can secrete different types of EVs depending on their biological state. These vesicles can influence the physiological properties and pathological processes of skin, such as pigmentation, cutaneous immunity, and wound healing. Since keratinocytes constitute the majority of skin cells, secreted EVs from these cells may alter the pathophysiological behavior of other skin cells. This paper reviews the contents of keratinocyte-derived EVs and their impact on fibroblasts, melanocytes, and immune cells to provide an insight for better understanding of the pathophysiological mechanisms of skin disorders and their use in related therapeutic approaches.
Asymmetric synthesis of .gamma.,.gamma.-dialkyl-.gamma.-aminobutyric acid analogs and 2,2-disubstituted pyrrolidines. Control of stereochemistry in aminal ring opening by varying the extent of allylic 1,3 strain (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis of .gamma.,.gamma.-dialkyl-.gamma.-aminobutyric acid analogs and 2,2-disubstituted pyrrolidines. Control of stereochemistry in aminal ring opening by varying the extent of allylic 1,3 strainLaurence E. Burgess and A. I. MeyersCite this: J. Am. Chem. Soc. 1991, 113, 26, 9858–9859Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00026a026https://doi.org/10.1021/ja00026a026research-articleACS PublicationsRequest reuse permissionsArticle Views909Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparative Population Analysis of Klebsiella pneumoniae Strains with Extended-Spectrum β-Lactamases Colonizing Patients in Rehabilitation Centers in Four Countries (2013)

The international project MOSAR was conducted in five rehabilitation centers; patients were screened for rectal carriage of extended-spectrum β-lactamase (ESBL)-producing members of the Enterobacteriaceae. Among 229 Klebsiella pneumoniae isolates, four clonal groups (CG) or complexes (CC) prevailed: CG17 in France, CG101 in Italy, CG15 in Spain, and CC147 in Israel. ESBLs, mainly CTX-Ms, were produced by 226 isolates; three isolates expressed AmpC-like cephalosporinases. High genetic diversity of K. pneumoniae populations was observed, with specific characteristics at each center.
Modification of properties of ion‐exchange membranes. IV. Change of transport properties of cation‐exchange membranes by various polyelectrolytes (1978)

Abstract A change in electrodialytic transport properties of various cation exchange membranes was observed after the membranes had been adsorbed or ion‐exchanged with various cationic polyelectrolytes. Transport properties measured in this report were the relative transport number of calcium ion to sodium ion P Ca Na , the current efficiency of cations, and the electric resistance of the membrane during the electrodialysis. Weakly basic and strongly basic cationic polyelectrolytes of various molecular weights were used. Though P Ca Na of any cation exchange membrane decreased by the adsorption or ion exchange of any cationic polyelectrolyte, the degree of the decrease in P Ca Na changed with species and molecular weight of polyelectrolytes and species of cation‐exchange membranes. Weakly basic polyelectrolytes and low molecular weight, strongly basic polyelectrolytes were effective in producing a marked decrease in P Na Ca of any cation exchange membrane. The effect of strongly basic polyelectrolytes of high molecular weight on P Ca Na was weak in most cases. However, if it was possible to make the polyelectrolyte adhere to the surface of the membrane to form a compact coiled structure, any cationic polyelectrolyte was effective in producing a remarkable decrease in P Ca Na of any cation‐exchange membrane.
Molecular Characterization of Semi-Fluorinated Copolymers with a Controlled Amount of Long-Chain Branching (2006)

The molecular structure of various semi-fluorinated polymers derived from tetrafluoroethylene, hexafluoropropylene, and vinylidenefluoride is examined by different characterization methods in dilute solution. The polymer synthesis was tailored to set up samples with a straight linear topography as well as model polymers with a controlled amount of long chain branching. As anticipated from the reaction kinetics of the polymerization process, the absolute molar mass distributions of the linear samples as obtained by size exclusion chromatography coupled with multiangle light scattering are well described by a Schulz−Zimm distribution. With [η] ∼ M0.73 and 〈s2〉1/2 ∼ M0.53 in THF, scaling laws typical of coil dimensions of linear macromolecules in good solvents were observed. In the second set of samples, the presence of long-chain branching (LCB) becomes evident from a reduced radius of gyration in the high molar mass region. Solution viscometry on the polydisperse samples reveals a decreasing contraction factor gη = [η]br/[η]lin of the intrinsic viscosity (equivalent to g‘ as introduced by Zimm and Kilb) with increasing amount of branching agent utilized in the polymer synthesis. The branching parameter ε determined from gη together with the contraction factor of the radius of gyration gs = 〈s2〉br/〈s2〉lin is found to be increasing from 0.5 for M < 106 g/mol to about 1.3 at higher molar masses, which is indicative of a topography change from a starlike to a comblike polymer architecture.
Establishment and characterization of a human cell line from a squamous carcinoma of the tongue (1995)

A human squamous carcinoma cell line, PWH-S1, has been established from the metastatic lymph node of a Chinese patient with a squamous cell carcinoma of the tongue. The fibroblast-free culture has been propagated in DMEM supplemented with 10% fetal bovine serum for more than 100 passages. PWH-S1 cells showed anchorage-independent growth in 0.3% agar solution. PWH-S1 cell line exhibited a monolayer growth and loss of contact inhibition. The in vitro doubling time of the PWH-S1 cell line was approximately 28 h. PWH-S1 was tumourigenic after inoculation into nude mice. Karyotype analysis showed the chromosome abnormality with a modal number of 69. Electron microscopy demonstrated poorly differentiated neoplastic cells with some features of squamous cell differentiation. No human papillomavirus (type 6, 11, 16, 18, 31) was detected in the PWH-S1 cell line by the polymerase chain reaction.
Studies of Avian Leukosis Virus Infection in Chickens from a Commercial Breeder Flock (1982)

Progeny chicks from a commercial breeder flock with a high rate of avian leukosis virus (ALV) infection were classified as congenitally or contact infected with ALV on the basis of virus tests on their meconia at hatching and the presence or absence of antibodies at 20 weeks of age. The ALV infection profile, shedding, tumor mortality, and egg production in the congenitally-infected chickens were compared with those in the contact-infected hatchmates. Results show that viremic-tolerant hens classed as congenitally infected consistently shed virus into albumen of their eggs and progeny and 18% died from tumors. In contrast, hens classified as contact infected had a transient viremia; most of them developed antibody to ALV, and only 10% shed virus into albumen and progeny. No mortality from tumors occurred in this group of chickens during the 48-week experimental period, and egg production was significantly higher than in the group classified as congenitally infected. In addition, progeny chickens hatched from the contact-infected group maintained a low rate (2.9 to 3.8%) of ALV infection for the next two generations without further selection. These data further document principles and procedures for reduction of ALV infection in commercial flocks and the considerable economic benefits to be derived therefrom.
Evolution and Functional Morphology of the Proboscis in Kalyptorhynchia (Platyhelminthes) (2015)

Predatory flatworms belonging to the taxon Kalyptorhynchia are characterized by an anterior muscular proboscis that they use to seize prey. In many cases, the proboscis is armed with hooks, derived either from the extracellular matrix that surrounds the muscles or from intracellular deposits in the epithelium covering the proboscis. Glands associated with the proboscis reportedly are venomous; however, there are few direct tests of this hypothesis. This article reviews the structure and current knowledge of the function of the proboscis in the Kalyptorhynchia, points to areas in which the current understanding of phylogenetic relationships within this taxon is incongruent with our hypothesis of how the proboscis evolved, and addresses areas in need of further research, especially as regards functional morphology and biomechanics.
Social Inequalities of Oral Anticoagulation after the Introduction of Non-Vitamin K Antagonists in Patients with Atrial Fibrillation (2019)

Introduction of NOACs in routine practice for stroke prevention in AF was associated with improved rates of overall OAC use. However, significant practice-level variations in OAC and NOAC use remain producing social inequalities of OAC despite full reimbursement.
Low Cost Electrodes for Proton Exchange Membrane Fuel Cells: Performance in Single Cells and Ballard Stacks (1997)

Low Cost Electrodes for Proton Exchange Membrane Fuel Cells: Performance in Single Cells and Ballard Stacks, Ralph, T. R., Hards, G. A., Keating, J. E., Campbell, S. A., Wilkinson, D. P., Davis, M., St‐Pierre, J., Johnson, M. C.
Feature specificity of global-feature-based-attention (2010)

Purpose: Previous studies have shown evidence of a global feature-based attentional mechanism in which attention to a particular stimulus feature, such as direction of motion or color, enhances neural responses to unattended stimuli sharing that feature (Saenz, Buracas, and Boynton 2002). We used the motion aftereffect (MAE) to measure this effect psychophysically, and to determine whether this effect is specific to only the attended feature or whether it spreads to other features of the attended stimulus. Methods: Subjects performed a two-interval-forced-choice (2IFC) speed or luminance discrimination task on a field of moving dots presented either to the left or right of fixation. The attended hemifield also contained a field of overlapping dots moving in the opposite direction. Simultaneously, on the opposing visual hemifield, a field of dots moved either in the direction of the attended dots, in the opposite direction, or had uncorrelated motion. Immediately following each 2IFC trial, subjects were presented with a unidirectional field of slowly moving dots on the previously unattended side and indicated whether the dots appeared to move either upward or downward. The strength of the MAE was measured as the speed in which the slowly moving dots appeared to move upward or downward with equal probability. Results: We found that for both the speed and luminance discrimination task, there was a systematic influence of the direction of the attended dots on the strength of the MAE. For example, when subjects attended to either the speed or luminance of the upward moving dots on the left side, an unattended field of uncorrelated moving dots on the right side induced a MAE in the downward direction. These results suggest that attention to a stimulus enhances the response to all unattended stimuli that share any feature in common with the attended stimulus.
Transcriptome Analysis Identified 2 New lncRNAs Associated with the Metastasis of Papillary Thyroid Carcinoma (2021)

Our findings preliminarily reveal the molecular mechanisms for PTMC metastasis, which will provide vital reference for subsequent studies about the genetic basis and molecular targeted therapy for PTMC metastasis.
Efficient And Simple High-Power Femtosecond Yb:KGW Slab-Laser Pumped By A Single Broad-Area Emitter Diode (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. Hoos, T. P. Meyrath, S. Li, B. Braun, and H. Giessen, "Efficient And Simple High-Power Femtosecond Yb:KGW Slab-Laser Pumped By A Single Broad-Area Emitter Diode," in Advanced Solid-State Photonics, OSA Technical Digest Series (CD) (Optica Publishing Group, 2009), paper MB13. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
LOW HLA-DR EXPRESSION ON MONOCYTES AS A PROGNOSTIC MARKER FOR BACTERIAL SEPSIS AFTER LIVER TRANSPLANTATION (1997)

Monitoring of monocyte HLA-DR expression may be helpful in identifying liver transplant patients who have an increased risk of imminent bacterial sepsis.
Coherent Phonon Coupling to Individual Bloch States in Photoexcited Bismuth (2012)

We investigate the temporal evolution of the electronic states at the bismuth (111) surface by means of time- and angle-resolved photoelectron spectroscopy. The binding energy of bulklike bands oscillates with the frequency of the A(1g) phonon mode, whereas surface states are insensitive to the coherent displacement of the lattice. A strong dependence of the oscillation amplitude on the electronic wave vector is correctly reproduced by ab initio calculations of electron-phonon coupling. Besides these oscillations, all the electronic states also display a photoinduced shift towards higher binding energy whose dynamics follows the evolution of the electronic temperature.