gebhart/patrepeval huggingface dataset:
The role of the Industry 4.0 asset administration shell and the digital twin during the life cycle of a plant (2017)

Industry 4.0 has come up with an impressive number of additional terms and definitions e.g. Asset Administration Shell or Digital Twin. Those terms stand for Industry 4.0 coreparadigms, but their meaning is not harmonized even among experts. This is a source of misunderstanding and confusion. In this paper, the mentioned terms are discussed along the life cycle of a plant. A plant's life cycle comprises the whole process from its idea to its destruction. During the discussion of the terms not only the concepts, but also the visions of Industry 4.0 are clarified. Goal of this paper is not to define additional terms, but to explain and substantiate existing ones and to solve apparent contradictions. Additional outcome of the discussion are architectural recommendations for an upcoming Industry 4.0 architecture. Moreover, suggestions for device manufacturers, system integrators, plant owners and Industry 4.0 architects are given.
Physics and technology of semiconductor devices (1967)

The Planar Technology. Solid-State Technology. Vapor-Phase Growth. Thermal Oxidation. Solid-State Diffusion. Semiconductors and Semiconductor Devices. Elements of Semiconductor Physics. Semiconductors under Non-Equilibrium Conditions. p-n Junction. Junction Transistor. Junction Field-Effect Transistors. Surface Effects and Surface-Controlled Devices. Theory of Semiconductor Surfaces. Surface Effects on p-n Junctions. Surface Field-Effect Transistors. Properties of the Silicon-Silicon Dioxide System.
Recombinant self-assembling peptides as biomaterials for tissue engineering (2010)

Synthetic nanostructures based on self-assembling systems that aim to mimic natural extracellular matrix are now being used as substrates in tissue engineering applications. Peptides are excellent starting materials for the self-assembly process as they can be readily synthesised both chemically and biologically. P₁₁-4 is an 11 amino acid peptide that undergoes triggered self-assembly to form a self-supporting hydrogel. It exists as unimers of random coil conformations in water above pH 7.5 but at low pH adopts an antiparallel β-sheet conformation. It also self-assembles under physiological conditions in a concentration-dependent manner. Here we describe an unimer P₁₁-4 production system and the use of a simple site-directed mutagenesis approach to generate a series of other P₁₁-family peptide expression vectors. We have developed an efficient purification strategy for these peptide biomaterials using a simple procedure involving chemical cleavage with cyanogen bromide then repeated filtration, lyophilisation and wash steps. We report peptide-fusion protein yields of ca. 4.64 g/L and we believe the highest reported recovery of a recombinant self-assembling peptide at 203 mg/L of pure recombinant P₁₁-4. This peptide forms a self-supporting hydrogel under physiological conditions with essentially identical physico-chemical properties to the chemically synthesised peptide. Critically it also displays excellent cytocompatibility when tested with primary human dermal fibroblasts. This study demonstrates that high levels of a series of recombinant self-assembling peptides can be purified using a simple process for applications as scaffolds in tissue engineering.
Bottom-Up Nanofabrication of Supported Noble Metal Alloy Nanoparticle Arrays for Plasmonics (2016)

Mixing different elements at the nanoscale to obtain alloy nanostructures with fine-tuned physical and chemical properties offers appealing opportunities for nanotechnology and nanoscience. However, despite widespread successful application of alloy nanoparticles made by colloidal synthesis in heterogeneous catalysis, nanoalloy systems have been used very rarely in solid-state devices and nanoplasmonics-related applications. One reason is that such applications require integration in arrays on a surface with compelling demands on nanoparticle arrangement, uniformity in surface coverage, and optimization of the surface density. These cannot be fulfilled even using state-of-the-art self-assembly strategies of colloids. As a solution, we present here a generic bottom-up nanolithography-compatible fabrication approach for large-area arrays of alloy nanoparticles on surfaces. To illustrate the concept, we focus on Au-based binary and ternary alloy systems with Ag, Cu, and Pd, due to their high relevance for nanoplasmonics and complete miscibility, and characterize their optical properties. Moreover, as an example for the relevance of the obtained materials for integration in devices, we demonstrate the superior and hysteresis-free plasmonic hydrogen-sensing performance of the AuPd alloy nanoparticle system.
The effects of lead and zinc ion exposure on the antioxidant status of mice liver (2011)

The present study was conducted to investigate the effect of lead (Pb) and / or zinc (Zn) ions on the content of metallothionein (MT), reduced glutathione (GSH) and malondialdehyde (MDA) in mouse liver. Two weeks of mice intraperitoneal treatment with ZnSO4 and Pb(CH3COO)2 solutions, increased the content of MT by 25% and 55%, respectively. Mice pre-treatment with ZnSO4 for 20 min before Pb(CH3COO)2 injections, attenuated the effect of Pb2+ and partly reduced (by 30%) the increase of MT content in mice liver. Two weeks of administration with Pb(CH3COO)2 solution, induced the decrease of GSH content by 22% comparing to the control. Treatment with ZnSO4 didn’t have any effect on the content of GSH. Pre-treatment with ZnSO4 for 20 min before Pb(CH3COO)2 injections decreased GSH content in mice liver by 48% as compared to the control group of mice. Neither Pb2+ nor Zn2– caused any remarkable alterations on MDA content in liver of mice. Keywords: lead, zinc, metallothionein, reduced glutathione, malondialdehyde, oxidative stress
Activation-Induced CD4+ T Cell Death in HIV-Positive Individuals Correlates with Fas Susceptibility, CD4+ T Cell Count, and HIV Plasma Viral Copy Number (1999)

The relevance of activation-induced cell death (AICD) of CD4+ T cells to AIDS pathogenesis is unknown. The present study investigates the relationship of AICD to a defined molecular mechanism regulating peripheral T cell homeostasis, Fas-mediated apoptosis, and clinical correlates of the pathogenesis of AIDS. Increased pokeweed mitogen (PWM)-induced AICD (22.8 versus 4.4%, p = 0.006) and Fas-mediated apoptosis (27.7 versus 12.0%, p = 0.002) of CD4+ T cells were observed in HIV+ versus HIV- individuals. Similarly, increased PWM-mediated AICD (16.2 versus 2.2%, p < 0.001) and Fas-mediated apoptosis (25.8 versus 7.6%, p = 0.005) were noted in CD8+ T cells from HIV+ versus HIV- individuals. PWM-induced AICD of CD4+ T cells was blocked (83% median specific inhibition) by Fas-blocking antibodies, whereas PWM-induced AICD of CD8+ T cells was Fas independent. Comparison between PWM- and anti-CD3-mediated AICD of CD4+ T cells indicated that PWM- and not CD3-induced AICD is Fas dependent. HIV+ individuals with an HIV RNA copy number of <30,000 copies/ml had lower PWM-induced AICD of CD4+ T cells than did those with an HIV RNA copy number of >30,000 copies/ml (5.7 versus 22.1%, p = 0.034), and PWM-induced AICD inversely correlated with CD4+ T cell count (R = -0.567, p = 0.043). Initiation of HAART decreased PWM-induced CD4+ T cell AICD from 24.4 to 9.4% posttreatment (p = 0.035). These results demonstrate that PWM-induced AICD of CD4+ T cells from HIV+ individuals is mediated by Fas/FasL, parallels the in vivo susceptibility of the CD4+ T cell to Fas-mediated apoptosis, and correlates with clinical markers of AIDS pathogenesis and response to HAART.
SARS-CoV-2 neutralizing antibody response after three doses of mRNA1273 vaccine and COVID-19 in hemodialysis patients (2022)

Our results suggest that most hemodialysis patients have a strong humoral response to the third dose of vaccination and an even stronger post-COVID-19 humoral response. Nevertheless, nAb levels clearly decay over time. These findings may inform ongoing discussions regarding a fourth vaccination in hemodialysis patients.
Novel three-dimensional NMR techniques for studies of peptides and biological macromolecules (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel three-dimensional NMR techniques for studies of peptides and biological macromoleculesC. Griesinger, O. W. Sorensen, and R. R. ErnstCite this: J. Am. Chem. Soc. 1987, 109, 23, 7227–7228Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00257a074https://doi.org/10.1021/ja00257a074research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scanning frequency comb microscopy (SFCM): A new method showing promise for high-resolution carrier profiling in semiconductors (2014)

A microwave frequency comb (MFC) with hundreds of measurable harmonics is superimposed on the DC tunneling current in a scanning tunneling microscope by focusing a mode-locked ultrafast laser on the tunneling junction. Two methods for carrier profiling of semiconductors by hyperspectral measurements with the MFC are considered. The first method, analogous to scanning capacitance microscopy (SCM), would require high-precision measurements because resonant detection, required in SCM, is not practical with the MFC. The second method, analogous to scanning spreading resistance microscopy (SSRM), is more sensitive to the carrier concentration and shows promise for achieving sub-nm resolution which is needed by the semiconductor industry with sub-10 nm lithography.
Routes to Endocyclic Sulfoximides Via Electrophilic Amination Reactions (1999)

Reaction of a 2-carboxyphenyl sulfide with non-anhydrous O-(mesityl-enesulfonyl)-hydroxylamine (MSH) in excess gives the corresponding endocyclic sulfoximides, while reaction with anhydrous MSH leads to the respective sulfimides.
Power Control in Wireless Cellular Networks (2007)

Power Control in Wireless Cellular Networks provides a comprehensive survey of the models, algorithms, analysis, and methodologies in this vast and growing research area. It starts with a taxonomy of the wide range of power control problem formulations, and progresses from the basic formulation to more sophisticated ones. When transmit power is the only set of optimisation variables, algorithms for fixed SIR are presented first, before turning to their robust versions and joint SIR and power optimization. This is followed by opportunistic and non-cooperative power control. Then joint control of power together with beamforming pattern, base station assignment, spectrum allocation, and transmit schedule are surveyed one by one. Power Control in Wireless Cellular Networks highlights the use of mathematical language and tools in the study of power control, including optimisation theory, control theory, game theory, and linear algebra. Practical implementations of some of the algorithms in operational networks are discussed in the concluding chapter.
SYNJ2 Variant Rs9365723 is Associated with Colorectal Cancer Risk in Chinese Han Population (2015)

Our results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. Thus, SYNJ2 may play a role in the development of CRC, especially colon cancer.
A family of isolated single-stage ZVS-PWM active-clamping converters (2003)

A family of isolated single-stage ZVS-PWM active-clamping converters with high power factor are proposed. These new converters can achieve high power factor, low current harmonic distortion, tight output voltage regulation, and high efficiency. In the converters, the switches are operated with zero voltage switching (ZVS) and active clamping. They may become very attractive in low or medium power applications. In this paper, derivation of the single-stage converters is presented, and a specific example is designed and implemented to verify the feasibility of the converters.
Detection of E. coli O157:H7 Using a Surface Plasmon Resonance Biosensor (2001)

A surface plasmon resonance (SPR) biosensor is employed in this study to detect Escherichiacoli O157:H7. The SPR biosensor couples antibody-antigen reactions with signal generation,using Kretschmann geometry to couple light into surface plasmons. The objective of this studywas to verify the feasibility of employing an SPR biosensor to detect E. coli O157:H7 by testingthe sensitivity and specificity of the SPR biosensor assays. Tests were conducted at near real-timewith results obtained for one SPR biosensor assay within 35 min. The limit of detection forE. coli O157:H7 was determined to be 107CFU/ml. The SPR biosensor was specific to E. coliO157:H7 in pure cultures at concentrations of 107CFU/ml. In mixed cultures, the detection limitof the biosensor was 107CFU/ml for E. coli O157:H7, when the non-target bacterialconcentration was 106CFU/ml or less. Concentrations of non-target bacteria beyond 107CFU/ml caused a decrease in the magnitude of the sensor response. The results of this studydemonstrate the potential for employing the SPR biosensor to detect E. coli O157:H7 in nearreal-time. The SPR biosensor shows potential as a tool to assist the food industry in pathogenmonitoring that is quick, sensitive, and specific. Due to its portability, it can potentially beincorporated into a HACCP protocol in the food industry.
Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry (2018)

Renibacterium salmoninarum is the causative agent of bacterial kidney disease (BKD), which is a commercially important disease of farmed salmonids. Typing by conventional methods provides limited information on the evolution and spread of this pathogen, as there is a low level of standing variation within the R. salmoninarum population. Here, we apply whole-genome sequencing to 42 R. salmoninarum isolates from Chile, primarily from salmon farms, in order to understand the epidemiology of BKD in this country. The patterns of genomic variation are consistent with multiple introductions to Chile, followed by rapid dissemination over a 30 year period. The estimated dates of introduction broadly coincide with major events in the development of the Chilean aquaculture industry. We find evidence for significant barriers to transmission of BKD in the Chilean salmon production chain that may also be explained by previously undescribed signals of host tropism in R. salmoninarum. Understanding the genomic epidemiology of BKD can inform disease intervention and improve sustainability of the economically important salmon industry. This article contains data hosted by Microreact.
High Frame Rate Ultrasonic Imaging through Fourier Transform using an Arbitrary Known Transmission Field (2011)

High Frame Rate Ultrasonic Imaging through Fourier Transform using an Arbitrary Known Transmission Field
Clinical Trials in the COVID-19 Era: A breakdown of FDA Guidance and Future Considerations (2020)

Clinical trials that involve medical products are critical to advancing treatments in any medical field and are designed with careful thought and attention to detail. These details include careful assessment of safety parameters from patient safety visits, lab work and deliberately placed screening parameters. Meticulous planning for primary, secondary and correlative outcomes is completed by the study team and the biostatisticians involved in each study design. These precise measures are then methodically written as a clinical trial protocol and submitted to regulatory bodies such as the Food and Drug Administration (FDA) often as an Investigational Drug Application (IND) and also submitted to the Institutional Review Board (IRB) so that a study can have the appropriate regulatory approval to be tested for the desired outcome. The Principal Investigator (PI) and study team are required to follow these protocols and regulatory requirements with exactitude to maintain clinical trial integrity. While there are many models projecting variances in the timeframe of this pandemic, it is very possible that these modifications will be in place for months/years to come in varying intensities, so it is imperative that we understand them if we participate in clinical trials moving forward.
Simultaneous extraction of cellular lipids and water‐soluble metabolites: Evaluation by NMR spectroscopy (1996)

A method for simultaneous extraction of lipids and water-soluble metabolites from a single cell sample was developed and optimized for NMR spectroscopy. Intermediary metabolites in cultured M2R mouse melanoma cells and changes therein in response to challenge with melanotropin were studied by 31P and 13C NMR. Cells were extracted with methanol, chloroform, and water (1:1:1, v/v/v). The contents of the chloroform and methanol-water phases were separated and quantitatively recovered. The contents of the upper and lower phases compared well with the homologous fractions obtained by perchloric acid and Folch's lipid extraction methods. The pH of the extracts remained within the physiologic range, eliminating potential deleterious effect on cellular metabolites. The water phase contained minimal amounts of salts, making these extracts amenable to subsequent analytical procedures. Obtaining lipid- and water-soluble metabolites from the same sample enables characterization of metabolic pathways that bridge the two cellular components in a quantitative manner.
Aspect-Oriented Programming and Aspect.NET as Security and Privacy Tool for Web and 3D Web Programming (2011)

This chapter covers the use of aspect-oriented programming (AOP) and Aspect.NET, an AOP toolkit for the .NET platform, to implement Web and 3D Web security and privacy. In this chapter the author shows that AOP is quite suitable as a trustworthy software development tool. AOP and Aspect.NET basics are overviewed using simple examples. Principles of applying Aspect.NET for Web and 3D Web security and privacy implementation are also discussed. The chapter presents a library of sample aspects implementing security and privacy for Web programming.
ACT-01 THE SECOND GENERATION ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITOR CERITINIB EFFECTIVELY INDUCES CELL DEATH IN HUMAN GLIOBLASTOMA CELLS (2019)

Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase which expresses only in the developmental stage of the brain during embryogenesis of human. On the other hand, a variety of ALK gene alterations, such as oncogenic fusion, activating point mutation, or wild type gene amplification, have been recently discovered as the powerful oncogene in various tumors, and these ALK mutations have also been known as the potential therapeutic targets against tumors harboring these ALK mutations. For example, ALK inhibitors have been already approved and used for the clinical treatment of non-small cell lung cancers harboring oncogenic ALK fusion. Previously, we reported classical ALK inhibitors triggered cell death in human glioblastoma (GBM) cells, which did not express ALK, via suppression of transcription factor STAT3 activation but not in normal tissue-derived cells. In this study, we investigated the anti-tumor effect of newly-developed ALK inhibitors in GBM cells. As a result, a second generation ALK inhibitor ceritinib induced cell death in various human GBM cell lines with lower concentration compared to other ALK inhibitors. Besides, ceritinib also suppressed STAT family activity in these GBM cell lines. From these results, we consider ceritinib might be a novel therapeutic agent against GBMs, and further investigation about the specific anti-tumor mechanism of ceritinib in GBM cells is currently on-going.
Seven steps to successful change: How a large academic medical center prepared patients for organizational change (2019)

Vanderbilt University Medical Center (VUMC) launched a new electronic health record (EHR) in a “big bang” implementation that saw the new software go live across multiple hospitals, clinics and geographic locations in a single morning. The organization rightly focused most of its energy on preparing its nearly 25,000 employees for the impacts of the transition, but it also considered the effects that would be felt by its patients and families. Survey data indicate that patient satisfaction scores demonstrably dip before, during and after an EHR implementation, and take approximately a year to recover. A team at DMC employed a seven-step approach to preparing patients for the impacts of the transition, which led to a return to pre-implementation patient satisfaction scores in about half the time of its peer institutions. The article explores these seven steps in detail and offers recommendations for how healthcare organizations facing large-scale change can use a similar structured approach to mitigate negative impacts to patients. <strong>Experience Framework</strong> This article is associated with the Culture & Leadership lens of The Beryl Institute Experience Framework. (<a href="http://bit.ly/ExperienceFramework">http://bit.ly/ExperienceFramework</a>) <ul> <li><a href="https://www.theberylinstitute.org/page/PXSEARCH#resource-list-all/?view_28_page=1&view_28_filters=%5B%7B%22field%22%3A%22field_38%22%2C%22operator%22%3A%22in%22%2C%22value%22%3A%5B%22PXJ%20Article%22%5D%7D%2C%7B%22field%22%3A%22field_20%22%2C%22operator%22%3A%22is%22%2C%22value%22%3A%5B%22%22%5D%7D%2C%7B%22field%22%3A%22field_40%22%2C%22operator%22%3A%22is%22%2C%22value%22%3A%5B%22%22%2C%22Culture%20%26%20Leadership%22%5D%7D%2C%7B%22field%22%3A%22field_41%22%2C%22operator%22%3A%22is%22%2C%22value%22%3A%5B%22%22%5D%7D%5D">Access other PXJ articles</a> related to this lens.</li> <li><a href="https://www.theberylinstitute.org/page/Ecosystem-CultureLeadership">Access other resources</a> related to this lens</li> </ul>
Supply chain management and NFC picking demonstrations using the AspireRfid middleware platform (2008)

RFID middleware is a cornerstone of non-trivial RFID deployments in complex heterogeneous environments. In this demonstration, we introduce and present the AspireRfid middleware platform using demonstrators in the area of Supply Chain management and Near Field Communications. The AspireRfid platform provides support for non-trivial RFID applications in several fields including supply-chain management, logistics, access control, asset management and pharmaceuticals. In this demonstration we present a traceability application for logistics and supply chain management, as well as a pick and pack application. AspireRfid implements several building blocks of the EPCglobal architecture. However, it also extends the EPCglobal architecture with several middleware modules, which can greatly facilitate RFID application development and deployment. Hence, prior to presenting the demonstrations, we provide a brief discussion of the EPCglobal architecture and the extensions implemented by AspireRFid. We end-up with an illustration of the demonstrators.