gebhart/patrepeval huggingface dataset:
Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma. (1991)

A Phase I trial of tumor-infiltrating lymphocytes (TIL) expanded in vitro and administered on Days 1 and 8, with or without continuous infusion recombinant interleukin 2 (rIL-2) in 25 patients with metastatic renal cell carcinoma, was conducted. Eighteen of the 25 eligible patients were treated with TIL and escalating doses of rIL-2 (0.0, 3.0, 4.5 x 10(6) units/m2) on Days 1 to 5 and 8 to 12. Dose-limiting toxicity was pulmonary, and the maximum tolerated dose of rIL-2 was 3.0 x 10(6) units/m2. No clinical responses were observed. Immunological monitoring of peripheral blood lymphocytes demonstrated significant increases in CD3+ and CD56+ cells, including the activated T-cell subsets. Phenotypic analysis of cultured TILs demonstrated significant heterogeneity and the presence of CD3+CD4+ and CD3+CD8+ T-cells, with CD3-CD56+ and CD3+CD56+ populations also present. The majority of cultured TILs expressed HLA-DR and CD45RO, with a variable number expressing CD25. The rIL-2-expanded TILs possessed cytotoxicity against allogeneic and autologous tumor, with cytolytic activity against only autologous tumor seen in one patient. Results demonstrate that in vitro expansion of TILs is possible, but further studies are needed to define the biology of TILs in renal cancer and to isolate and expand tumor-specific T-cells.
A role for netrin-1 in the guidance of cortical efferents (1997)

An intermediate target for axons leaving the cerebral cortex in embryonic mammals is the ganglionic eminence (GE), the embryonic precursor of the basal ganglia. The cues that direct these axons over the initial portion of their trajectory are not well understood, but could include both short-range and long-range attractants and repellents. In the present study, we provide evidence that corticofugal axons might be guided at least partly by a diffusible factor or factors originating in the lateral GE and the sulcus between the lateral and medial ridges of the GE (ISS), as well as evidence implicating the axonal chemoattractant netrin-1 in mediating these effects. Explants of lateral GE and ISS obtained from E12.5 and E13.5 mouse forebrain have a strong effect on both the outgrowth and orientation of corticofugal axons when cultured at a distance with explants of embryonic cortex in collagen gels. Netrin-1 mRNA is detected in these target tissues by in situ hybridization, and both netrin-1 protein and heterologous cells secreting netrin-1 can mimic the outgrowth-promoting effect of these target tissues in vitro. Furthermore, the growth of corticofugal axons is oriented toward an ectopic source of netrin-1 in vitro, and a function blocking anti-netrin-1 antiserum specifically abolishes the cortical axon outgrowth elicited by explants of lateral GE and the ISS in collagen gel cocultures. Taken together, these results suggest a role for netrin-1 in the attraction at a distance of early cortical axons by the GE. Thus in mammals -- as is also observed in nematodes -- the development of non-commissural projections in anterior regions of the embryo might be directed by mechanisms similar to those involved in directing the development of commissural projections in more posterior regions of the central nervous system.
Analytical Investigation of the Toughening Potential of a Failure Tailoring Concept (2010)

A parametric study has been performed to determine the upper bounds of toughening benefit achievable using an approximate model for the response of one-dimensional, tailored, flexible composite-material tethers with progressive failure. The tailoring concept is achieved through judicious arrangement of redundant load paths with unequal length and strength and has been proposed, modeled, and experimentally verified in previous research. The model is recast in this work using nondimensional material-independent parameters that are varied over ranges of interest in advanced composites. The effects of each parameter on the response of the tailored member are discussed. An increase of nearly two orders of magnitude in toughness over an untailored member is found to be attainable by taking complete advantage of the energy dissipated by the failure of each load path within the bounds of the study. Challenges to implementation of the tailored member as approximated by the model are also discussed.
Current–Voltage Characteristics of AlN/GaN Heterostructure Metal Insulator Semiconductor Diode (2001)

We fabricated heterostructure metal insulator semiconductor (Hetero-MIS) diodes with a Schottky metal-(Ni/Au)/AlN(6 nm)/n + -GaN(Si:3×10 18 cm -3 )/ohmic metal-(Ti/Al/Pt/Au) structure, and measured the dependence of current–voltage ( I – V ) characteristics of the diodes on the growth temperature of the AlN layer using low-pressure metalorganic chemical vapor deposition (MOCVD). We found that the current decreases as the growth temperature of the AlN layer decreases from 990°C to 650°C. We conclude that the current flows mainly between the columnar crystals of the AlN layer, because we found from the temperature dependence of the surface morphology of the AlN layer that the radius of the columnar crystals decreases and the height of the columns decreases as the growth temperature decreases, and because the measured I – V characteristics are in agreement with the simulated ones if we assume that the thickness of the AlN layer is about 2 nm, which is much less than the measured thickness of the columnar crystal of 6 nm.
Spatial Memoization: Concurrent Instruction Reuse to Correct Timing Errors in SIMD Architectures (2013)

This brief proposes a novel technique to alleviate the cost of timing error recovery, building upon the lockstep execution of single-instruction-multiple-data (SIMD) architectures. To support spatial memoization at the instruction level, we propose a single-strong-lane-multiple-weak-lane (SSMW) architecture. Spatial memoization exploits the value locality inside parallel programs, memoizes the result of an error-free execution of an instruction on the SS lane, and concurrently reuses the result to spatially correct errant instructions across MW lanes. Experiment results on Taiwan Semiconductor Manufacturing Company 45-nm technology confirm that this technique avoids the recovery for 62% of the errant instructions on average, for both error-tolerant and error-intolerant general-purpose applications.
3939 3D Vision-based Autonomous Landing and Take-off Control of Unmanned Small Helicopter (2005)

Helicopters are capable of VTOL (Vertical Take-Off and Landing), versatile maneuverability and flying among space-restricted areas at low speed. These characteristics make small helicopters good application platforms for site survey, power transmission line inspection, remote sensing, disaster investigation, mine detection and so on. In the development of unmanned autonomous helicopters, autonomous landing and take-off are the fundamental requirements for ease of operation and flying safety. This paper presents a 3D vision based method for take-off and landing control. Based on the information from 3D camera, we can estimate the height of helicopter above the ground, and at the same time we can know the flatness of the ground surface. This information is taken into consideration in our proposed two-sage landing controller to enable smooth and safe landing. We propose a combined feedforward and feedback approach for take-off control. The experimental results show good performance of the proposed method.
Characterization of wavelength-selective fiber-optic devices using a modified phase-shift method (2001)

We present a novel measurement setup that can be used for the complete characterization of fiber Bragg gratings and wavelength selective fiber-optic devices. Our setup is based on the phase-shift method (PSM), which we have modified to include the measurement of polarization-induced effects such as polarization-dependant loss (PDL) and polarization-mode dispersion (PMD). We measure the spectral response of devices used in transmission and in reflection, the wavelength dependency of the group delays due to chromatic and polarization-mode dispersion, and the wavelength dependency of the polarization-dependent loss. Experimental results are presented and sources of error are discussed. Comparisons with the Jones matrix eigenanalysis method for the measurement of PDL and differential group delay due to PMD have been carried out.
SELECTIVE INHIBITION OF VIRAL FUNCTIONS: THE ANTIVIRAL ACTION OF INTERFERON AND STREPTOVARICIN (1972)

CARTER, WILLIAM A. M.D.; PITHA, PAULA M. PH.D.; BROCKMAN, WILLIAM W. M.D.; BORDEN, ERNEST C. M.D.; MARSHALL, LEWIS W. M.D. Author Information
Binding of manganese(II) to a tertiary stabilized hammerhead ribozyme as studied by electron paramagnetic resonance spectroscopy (2004)

Electron paramagnetic resonance (EPR) spectroscopy is used to study the binding of MnII ions to a tertiary stabilized hammer-head ribozyme (tsHHRz) and to compare it with the binding to the minimal hammerhead ribozyme (mHHRz). Continuous wave EPR measurements show that the tsHHRz possesses a single high-affinity MnII binding site with a KD of < or =10 nM at an NaCl concentration of 0.1 M. This dissociation constant is at least two orders of magnitude smaller than the KD determined previously for the single high-affinity MnII site in the mHHRz. In addition, whereas the high-affinity MnII is displaced from the mHHRz upon binding of the aminoglycoside antibiotic neomycin B, it is not from the tsHHRz. Despite these pronounced differences in binding, a comparison between the electron spin echo envelope modulation and hyperfine sublevel correlation spectra of the minimal and tertiary stabilized HHRz demonstrates that the structure of both binding sites is very similar. This suggests that the MnII is located in both ribozymes between the bases A9 and G10.1 of the sheared G . A tandem base pair, as shown previously and in detail for the mHHRz. Thus, the much stronger MnII binding in the tsHHRz is attributed to the interaction between the two external loops, which locks in the RNA fold, trapping the MnII in the tightly bound conformation, whereas the absence of long-range loop-loop interactions in the mHHRz leads to more dynamical and open conformations, decreasing MnII binding.
Depressive symptoms among community‐dwelling, post‐stroke elders in Hong Kong (2010)

The inclusion of psychosocial assessment and delivery of appropriate psychosocial interventions to post-stroke elders are recommended.
NUMERICAL SIMULATION OF A DEBRIS FLOW CAUSED BY LANDSLIDE (2003)

The soil block produced by a landslide sometimes runs out to the downstream area, and causes a severe disaster. If the fluidization of the soil block occurs, the run out distance becomes longer. And, if the soil block forms a natural dam, very big debris flow will occur with the destruction of the dam.We propose a two-dimensional numerical simulation model which can explain the run out process of the soil block including the fluidization of the soil block, the formation of a debris flow and deposition of the soil block. The model is composed of the usual two-dimensional debris flow model and a model which tracks the movement of the soil block. In the model, the soil block is considered as a set of several column units, and the interaction between each column units is taken into account. The base of the column unit is eroded due to the shear, and the eroded soil forms a debris flow part.
Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts (2018)

To realize human induced pluripotent stem cell (hiPSC)-based cardiac regenerative therapy, evidence of therapeutic advantages in human-sized diseased hearts are indispensable. In combination with an efficient and simultaneous differentiation of various cardiac lineages from hiPSCs and cell sheet technology, we aimed to generate clinical-sized large cardiac tissue sheets (L-CTSs) and to evaluate the therapeutic potential in porcine infarct heart. We simultaneously induced cardiomyocytes (CMs) and vascular cells [vascular endothelial cells (ECs) and vascular mural cells (MCs)] from hiPSCs. We generated L-CTSs using 10cm-sized temperature-responsive culture dishes. We induced myocardial infarction (MI) in micromini-pigs (15-25 kg) and transplanted the L-CTSs (Tx) 2 weeks after MI induction (4 sheets/recipient) under immunosuppression (Tx: n = 5, Sham: n = 5). Self-pulsating L-CTSs were approximately 3.5cm in diameter with 6.8×106±0.8 of cells containing cTnT+-CMs (45.6±13.2%), VE-cadherin+-ECs (5.3±4.4%) and PDGFRβ+-MCs (14.4±20.7%), respectively (n = 5). In Tx group, echocardiogram indicated a significantly higher systolic function of the left ventricle (LV) compared to that in sham control (Sham vs Tx: fractional shortening: 24.2±8.6 vs 40.5±9.7%; p<0.05). Ejection fraction evaluated by left ventriculogram was significantly higher in Tx group (25.3±6.2% vs 39.8±4.2%; p<0.01). Speckle tracking echocardiogram showed a significant increase of circumference strain in infarct and border regions after transplantation. Fibrotic area was significantly lower in Tx group (23.8±4.5 vs 15.9±3.8%; P<0.001). Capillary density in the border region was significantly higher in Tx group (75.9±42.6/mm2 vs 137.4±44.8/mm2, p<0.001). These data indicate that the L-CTS transplantation attenuated LV remodeling. L-CTSs potentially restore cardiac dysfunction of human-sized infarct heart.
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia (2012)

OATP1C1, OATP4A1, OATP4C1 seem to be involved in the excretory system of human colon. ABCC4 is likely to be involved from an endoplasmic-Golgi complex and basolateral location in goblet cells. ABCC5 might be directly involved in the turnover of intracellular cAMP at the basolateral membrane of columnar epithelial cells, while OATP2B1 is indirectly related to the excretory system. Colorectal neoplasia is associated with lower transport or sensitivity to cyclic nucleotides and increased expression of OATP2B1 and OATP4A1 transporters, known to transport PGE(2).
Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains (2018)

Clindamycin is a protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus. Recent guidelines recommend the use of clindamycin for the treatment of toxin-mediated infections. Clindamycin modulates virulence expression at sub-inhibitory concentrations (sub-MICs) in clindamycin-susceptible S. aureus strains but previous report shown that this effect was supressed for constitutive clindamycin resistant strains. However, no data are currently available on the impact of clindamycin at sub-MICs on the virulence of inducible clindamycin-resistant S. aureus strains. Here, we show that sub-MICs of clindamycin decrease Panton-Valentine leucocidin, toxic-shock-staphylococcal toxin (TSST-1) and alpha-haemolysin (Hla) expression in six inducible clindamycin-resistant isolates cultivated in vitro in CCY medium. These results suggest that the clindamycin anti-toxin effect is retained for inducible clindamycin-resistant S. aureus isolates; therefore, its usage should be considered within the treatment regimen of toxin related infections for inducible clindamycin-resistant S. aureus.
Hydrogen storage in a combined M.sub.xAlH.sub.6/M'.sub.y(NH.sub.2).sub.z system and methods of making and using the same (2012)

As a promising clean fuel for vehicles, hydrogen can be used for propulsion, either directly or in fuel cells. Hydrogen storage compositions having high storage capacity, good dehydrogenation kinetics, and hydrogen release and uptake reactions which are reversible are disclosed and described. Generally a hydrogen storage composition of a metal aluminum hexahydride and a metal amide can be used. A combined system (Li.sub.3AIH.sub.6/3LiNH.sub.2) with a very high inherent hydrogen capacity (7.3 wt %) can be carried out at moderate temperatures, and with approximately 95% of that inherent hydrogen storage capacity (7.0%) is reversible over repeated cycling of release and uptake.
Tar Sand Research and Development at the University of Utah (1987)

The recovery of hydrocarbon values fr om the extensive tar sand deposits of North America has generally been approached by one of two methods: in situ thermal production of the bitumen or of a bitumen-derived liquid or surface mining of the deposit followed by processing of the mined ore . In either approach the produced hydrocarbon liquid must be upgraded to give a suitable feedstock for subsequent processing in a conventional petroleum refinery .
Drug Retention and Safety of Secukinumab in a Real-World Cohort of Ankylosing Spondylitis and Psoriatic Arthritis Patients (2022)

Real-life data that support effectiveness of secukinumab (SEC), an interleukin 17A inhibitor, in Poland are few. We aimed to evaluate SEC effectiveness based on drug retention and safety measures reported in electronic medical records (EMRs) of patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS) from two tertiary-care centers in the region of Lesser Poland. A total one-hundred eighty seven (127 PsA and 60 AS) first (<i>n</i> = 112), second (<i>n</i> = 59) and third-line SEC users were enrolled. The mean (SD) age of the sample was 45.7 (12.9), and 48% were male. All patients were classified with active and severe disease prior to initiation. Administrative delays for SEC users last a median 2 weeks. Median delay from symptom onset to diagnosis was 4 years (IQR 8), and differed by predominant disease subtype. The inefficacy rate was 10.7% and 18.6% for first and second-line users with median (IQR) drug maintenance estimated at 1.22 years (1.46) and 1.51 (1.38), respectively. First-year drug loss defined as drug switch due to inefficacy or adverse event was rare, with median estimates of 0.91 (95% CI; 0.85, 0.97) and 0.86 (95% CI; 0.77, 0.95) for first and second-line, respectively.
Low-level rf control of Spallation Neutron Source: System and characterization (2006)

The low-level rf control system currently commissioned throughout the Spallation Neutron Source (SNS) LINAC evolved from three design iterations over 1 yr intensive research and development. Its digital hardware implementation is efficient, and has succeeded in achieving a minimum latency of less than 150 ns which is the key for accomplishing an all-digital feedback control for the full bandwidth. The control bandwidth is analyzed in frequency domain and characterized by testing its transient response. The hardware implementation also includes the provision of a time-shared input channel for a superior phase differential measurement between the cavity field and the reference. A companion cosimulation system for the digital hardware was developed to ensure a reliable long-term supportability. A large effort has also been made in the operation software development for the practical issues such as the process automations, cavity filling, beam loading compensation, and the cavity mechanical resonance suppression.
Lateral Control for Autonomous Parking System with Fractional Order Controller (2011)

Lateral control in autonomous parking system, which is always at low speed, simultaneously requiring very small following error, is a difficult problem to resolve.  To address this problem, this paper introduces the Fractional order controller. What’s more, to address the parameters tuning problem in design of the controller, an improved genetic algorithm is adopted. With the proposed method, simulation and real vehicle experiments are carried out. Results show that fractional order controller can manage the vehicle to follow the planned trajectory preciously and that stably and robustly in autonomous parking process, which is at low speed.
ChemInform Abstract: Enantioselective [1,2] Wittig Rearrangement Using an External Chiral Ligand. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<p>Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer</p> (2020)

Our results indicate that exo-si-c-Met can inhibit the invasion and migration of gastric cancer cells and promote apoptosis in vitro and inhibit tumor growth in vivo, reversing the resistance to cisplatin in gastric cancer.
Metallorganische molekulare Bäume als Mehrelektronen‐ und Mehrprotonenspeicher: CpFe+‐induzierte Nonaallylierung von Mesitylen und phasentransferkatalysierte Synthese eines redoxaktiven Nonaeisenkomplexes (1993)

Ein Speicher für 9 Elektronen und 27 Protonen ist Komplex 1 mit 8 ± 1 quasiäquivalenten Redoxzentren. Er wird aus [CpFe(η 6 ‐mesitylen)] + durch Nonaallylierung der drei Methylsubstituenten, Entmetallierung, Überführung in das entsprechende Nonaol und phasentransferkatalysierte Umsetzung mit [CpFe(FC 6 H 4 Me)] hergestellt. magnified image
Antisense RNA Control of Plasmid R1 Replication (1997)

The replication frequency of plasmid R1 is controlled by an antisense RNA (CopA) that binds to its target site (CopT) in the leader region of repA mRNA and inhibits the synthesis of the replication initiator protein RepA. Previous studies on CopA-CopT pairing in vitro revealed the existence of a primary loop-loop interaction (kissing complex) that is subsequently converted to an almost irreversible duplex. However, the structure of more stable binding intermediates that lead to the formation of a complete duplex was speculative. Here, we investigated the interaction between CopA and CopT by using Pb(II)-induced cleavages. The kissing complex was studied using a truncated antisense RNA (CopI) that is unable to form a full duplex with CopT. Furthermore, RNase III, which is known to process the CopA-CopT complex in vivo, was used to detect the existence of a full duplex. Our data indicate that the formation of a full CopA-CopT duplex appears to be a very slow process in vitro. Unexpectedly, we found that the loop-loop interaction persists in the predominant CopA-CopT complex and is stabilized by intermolecular base pairing involving the 5'-proximal 30 nucleotides of CopA and the complementary region of CopT. This almost irreversible complex suffices to inhibit ribosome binding at the tap ribosome binding site and may be the inhibitory complex in vivo.