gebhart/patrepeval huggingface dataset:
Field-structured composites for efficient, directed heat transfer (2009)

Thermally conductive composites are needed for a variety of applications, especially as thermal interface materials. Unfortunately, the addition of even highly conductive particles to a polymer raises its conductivity only slightly and incurs a commensurate increase in the viscosity of the prepolymer resin. Meaningful increases in the thermal conductivity of the final composite require a filled resin that has the rheology of a typical paste. In this paper, we report on the use of uniaxial, biaxial, and triaxial ac magnetic fields to organize thermally conductive magnetic particles into structures that conduct heat more efficiently. Experimental results are compared to an extension of the Maxwell–Eucken theory that takes into account spatial correlations between particles. Both theory and experiment show that the thermal conductivity of field-structured composites increases essentially linearly with particle loading, and that the enhancement is significantly greater than that of unstructured composites. The measured conductivity enhancements are found to be comparable to the enhancements in magnetic permeability of these composites and are far less than the enhancements in the electrical conductivity. These results indicate the value of field structuring in enhancing the performance of a thermal interface material and show that particle percolation is not a critical factor in achieving high performance.
Adaptive pulse skipping and adaptive compensation capacitance techniques in current-mode buck-boost DC-DC converters for fast transient response (2013)

To have a good power management especially for portable devices it is necessary to use the whole battery voltage range (e.g. of Lithium-ion batteries), to provide a fixed output voltage of for example 3V. In this paper a fast transient (FT) current mode buck-boost DC-DC converter with adaptive pulse skipping (APS) and adaptive compensation capacitance (ACC) is proposed. The buck-boost DC-DC converter can work in three different modes, buck, boost and buck-boost. It cannot only use the whole battery range from 2.7V to 4.2V, but also has a good response time with a low voltage undershoot/overshoot at load current variations, due to the APS and the ACC. With the proposed fast transient techniques, improvements could be made in the voltage overshoot/undershoot and the response time. In boost mode, the improvements, in the voltage undershoot and the response time from light-to-heavy load (100mA to 500mA), are 16.7% and 58.8%, respectively. In buck mode, 40% and 49.2% and in buck-boost mode, it is 10% and 63.9%. In case of a load variation from heavy-to-light load (500mA to 100mA), similar results could be reached in every operation mode. The proposed DC-DC buck-boost converter realizes a good power management and a good transient performance to generate a stable supply voltage for portable devices. Its working frequency is 1MHz.
AT THE AMINO ACID LEVEL (2000)

nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron microscopy, affinity labeling, and mutagenesis experiments, together with secondary structure predictions and measurements, suggest an all-b folding of the N-terminal extracellular domain, with the connecting loops contributing to the ACh binding pocket and to the subunit interfaces that mediate the allosteric transitions between conformational states. The ion channel consists of two distinct elements symmetrically organized along the fivefold axis of the molecule: a barrel of five M2 helices, and on the cytoplasmic side five loops contributing to the selectivity filter. The allosteric transitions of the protein underlying the physiological ACh- evoked activation and desensitization possibly involve rigid body motion of the extra- cellular domain of each subunit, linked to a global reorganization of the transmembrane domain responsible for channel gating.
Residências com Excesso de Animais Acompanhadas por Processo Administrativo pelo Centro de Controle de Zoonoses do Município de São Paulo, SP (2015)

De acordo com a Lei Municipal no 13.725/2004, artigo 23: “toda e qualquer instalacao destinada a criacao, a manutencao e a reproducao de animais, em zona urbana ou rural, deve ser construida, mantida e operada em condicoes sanitarias adequadas e sem causar incomodo a populacao e transtornos ao entorno.” Neste mesmo artigo, consta que os proprietarios dos imoveis residenciais sao responsaveis pela manutencao das instalacoes, obedecendo aos principios de bem-estar animal e adequacao as exigencias da especie. De acordo com a lei municipal no 13.131/2001, artigo 18., no municipio de Sao Paulo e permitida a posse de ate 10 animais, entre caes e gatos, por residencia. Residencias que possuem animais – caes e gatos – em excesso ocasionam transtornos ao entorno resultando em denuncias nos orgaos responsaveis.
Organosilicon Chemistry (1989)

ADVERTISEMENT RETURN TO BOOKPREVChapterNEXTOrganosilicon ChemistryA Brief OverviewThomas J. BartonThomas J. Barton Chemistry Department and Ames Laboratory (Department of Energy), Iowa State University, Ames, IA 50011More by Thomas J. Barton and Philip BoudjoukPhilip Boudjouk Chemistry Department, North Dakota State University, Fargo, ND 58105More by Philip BoudjoukDOI: 10.1021/ba-1990-0224.ch001 This publication is free to access through this site. Learn MorePublication Date (Print):May 5, 1989Publication History Published online22 July 2009Published inprint 5 May 1989Request reuse permissions Copyright © 1990 American Chemical Society. This publication is available under these Terms of Use. Silicon-Based Polymer ScienceChapter 1pp 3-46Advances in ChemistryVol. 224ISBN13: 9780841215467eISBN: 9780841224063Chapter Views4857Citations9LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) SUBJECTS:Energy,Materials Get e-Alerts
The Coronal Topology of the Rapidly Rotating K0 Dwarf AB Doradus. I. Using Surface Magnetic Field Maps to Model the Structure of the Stellar Corona (2002)

We re-analyse spectropolarimetric data of AB Dor taken in 1996 December using a surface imaging code that can model the magnetic field of the star as a non-potential current-carrying magnetic field. We find that a non-potential field needs to be introduced in order to fit the dataset at this epoch. This non-potential component takes the form of a strong unidirectional azimuthal field of a similar strength to the radial field. This azimuthal field is concentrated around the boundary of the dark polar spot recovered at the surface of the star using Doppler imaging. As polarization signatures from the center of starspots are suppressed, it is unclear whether or not this non-potential component genuinely represents electric current at the unspotted surface or whether it results from the preferred detection of horizontal field in starspot penumbrae. This model contains 20% more energy than the corresponding potential field model at the surface. This amount of free energy drops to under 1% about 1R* above the photosphere. We use these surface maps to model the coronal structure of the star. The mixed radial polarities at the pole in the surface maps support closed coronal loops in the high latitude regions, indicating that a component of the X-ray emission may originate in this area. Assuming that the field remains closed out to 5R*, we find stable surfaces where prominences may form out to the observed distances using this coronal model.
Correlation between In Vitro and In Vivo Activity of Antifungal Agents against Candida Species (1994)

The correlation between antifungal susceptibility testing and in vivo response to antifungal therapy was examined in experimental murine candidiasis. In vitro susceptibility testing was done using a microbroth dilution method. Twenty-two Candida albicans, 4 Candida lusitaniae, and 2 Candida krusei isolates were tested against fluconazole, flucytosine, and amphotericin B. In vivo antifungal activity was tested in murine hematogenous candidiasis. Normal CF1 mice were infected with each of the C. albicans strains; immunosuppressed CF1 mice were inoculated with C. lusitaniae or C. krusei. Mice received various doses of antifungal agents, and survival was monitored for 21 days. Kidney fungal burden was examined on day 4. Antifungal therapy significantly prolonged survival and reduced tissue counts in animals infected with organisms susceptible to the agent tested (P < .05). In vitro resistance to a drug predicted its lack of in vivo activity. These results appear to correlate well with outcome of murine hematogenous candidiasis.
Multiresolution permutation filters based on decision trees (2002)

Permutation filters are a broad class of nonlinear selection filters that utilize the complete spatial and rank order information of observation samples. The application of permutation filters is limited by the factorial growth in the number of spatial-rank orderings. Although M-permutation filters, which consider the spatial-rank ordering of a fixed sample subset, have been developed to address the growth in orderings, this method requires an a priori selection of samples that is uniformly applied. This uniform application is not appropriate in most cases. We develop a more general multiresolution approach based on decision trees. This implementation allows the level of ordering information utilized to automatically adjust to the problem at hand. Optimization procedures are developed for this method and simulation results illustrating its advantages are presented.
Self-assembled monolayers of bifunctional periodic mesoporous organosilicas for cell adhesion and cellular patterning (2012)

Periodic mesoporous organosilicas (PMOs), an important class of inorganic–organic functional hybrid materials, find numerous potential applications in nano- and biotechnologies due to their porous nature, large surface area (internal and external surfaces) and the structural diversity of their organosilica frameworks. In this contribution we report on the selective functionalization of both the internal and the external surfaces of PMOs with a fluorescent dye and bioactive molecules, respectively. Subsequently we used these unique bifunctionalized PMO nanoparticles for the preparation of non-patterned and patterned self-assembled monolayers (SAMs) on glass. In cell experiments we showed that these new biomaterial surfaces enhance cell adhesion. We were able to determine the position of the inside dye substituted PMOs of the biomolecule functionalized surface in relation to the position of the stained cells by fluorescence microscopy as well. Patterned SAMs of bifunctionalized PMOs lead to selective cellular patterning along the stripes (texture of the surface).
Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function (2021)

This study suggests the existence of a common genetic aetiology between LAM and pulmonary function.
PAVE II - Pilot Assistant in the Vicinity of Helipads (Wissenschaftlicher Abschlussbericht) (2008)

Arbeitsbelastung und Komplexität im Hubschrauber-Cockpit steigen vor dem Hintergrund der Missionsdurchführung auch unter schwierigsten Wetterbedingungen und dem angestrebten operationellen Einsatz rund um die Uhr. Insbesondere während der Start- und Landephase sind die Anforderungen an den Piloten sehr hoch. Der Hubschrauber wird hier oft in unmittelbarer Nähe zu Hindernissen betrieben, befindet sich in Bodennähe mit entsprechend sicherheitskritischer Relevanz eines Triebwerksausfalls und verursacht erheblichen Lärm, der sich störend auswirkt. Der Pilot ist somit gezwungen, spezielle Flugprozeduren mit relativ großer Präzision durchzuführen, seine Instrumente intensiv zu überwachen und den Hubschrauber auch bei schlechter Sicht so präzise zu steuern, dass der Flug sicher durchgeführt wird.&#13;\nZukünftige Pilotenassistenzsysteme sollen den Hubschrauberpiloten unterstützen und die Arbeitsbelastung in akzeptablen Grenzen halten, so dass der Hubschrauber nicht nur einfacher zu führen ist, sondern auch operationell effektiver, sicherer und leiser betrieben werden kann.&#13;\nZiel des Nachfolgeprojektes PAVE II war sowohl die Weiterentwicklung und Integration des in PAVE I entwickelten und im Bodensystem des FHS getesteten funktionalen Prototyps eines Hubschrauber-Pilotenassistenten als auch dessen Erprobung und Bewertung im Rahmen von Flugversuchen. Im Wesentlichen wurden An- und Abflüge mit dem flugtauglich weiterentwickelten und in den FHS eingerüsteten Pilotenassistenten durchzuführen, wobei der Pilot bei der Planung und Durchführung von Standardprozeduren und lärmarmen Flugprozeduren von dem Assistenten unterstützt wurde. &#13;\nWeiterhin wurde erprobt, in welcher Qualität der Assistent den Hubschrauber vollautomatisch entlang der geplanten Flugbahn führen kann und wie effektiv eine Pilotenunterstützung durch den Assistenten beim manuellen Fliegen ist. Es wurde gezeigt, dass die Führungsgenauigkeit im Bereich von wenigen Metern liegt.&#13;\nDie durch Verwendung des Pilotenassistenten ermöglichten und gegenüber den heutigen Verfahren schwieriger zu fliegenden lärmarmen Anflugprozeduren wurden im Flug auf deren Umsetzbarkeit überprüft. Zusätzlich wurde im Rahmen einer akustischen Messkampagne überprüft, ob mit den in PAVE I entwickelten Prozeduren die angestrebte Verringerung der Lärmemission am Boden von 6 dBa im Vergleich zu ICAO-Lärmzulassungsflügen auch tatsächlich erzielt werden kann.&#13;\n&#13;\nDieser Abschlussbericht beschreibt die wissenschaftlichen Ergebnisse der DLR-Institute Flugführung, Flugsystemtechnik, Planetenforschung und Aerodynamik und Strömungstechnik, die im Rahmen des internen DLR-Projektes PAVE II (Jan. 2006 – Okt. 2008) entstanden sind. Die diesem Projekt zugrundeliegende Aufgabenbeschreibung kann dem Projektplan entnommen werden. Ergebnisse werden nicht meilensteinorientiert dargestellt, sondern es wird versucht, im Kontext einen Gesamtüberblick über die erzielten wissenschaftlichen Ergebnisse zu geben.
Situated Engagement and Virtual Services in a Smart City (2014)

In the northern city of Oulu, Finland, we have been pursuing a visible change to the local society by building a functional prototype of what we call an open ubiquitous city. Today the ubiquitous city offers various permanent services as well as short-term research probes for its dwellers to use. In this article we first describe the still fermenting vision behind much of the service development in Oulu. Second, we introduce three new technological concepts that we are currently investigating in the smart city context: situated kiosks for community engagement, sound-based resource discovery mechanism, and a complete, functional 3D-model of the pivotal downtown areas of Oulu. Finally, we discuss some of the future research directions and implications of the introduced technological additions. We hope the ideas shared in this article can help the research community in designing and creating better services for the future cities.
Young Men With High-Normal Blood Pressure Have Lower Serum Adiponectin, Smaller LDL Size, and Higher Elevated Heart Rate Than Those With Optimal Blood Pressure (2002)

Young men with high-normal BP have a faster heart rate, lower serum adiponectin levels, and smaller LDL size than men with optimal BP, even after adjustment for BMI. These results suggest the necessity of preventing further development of cardiac and metabolic diseases in young people who have high-normal BP.
High‐temperature elastomers from silarylene‐siloxane‐diacetylene linear polymers (2001)

Abstract The syntheses and characterization of linear silarylene‐siloxane‐diacetylene polymers 3a–c and their thermal conversion to crosslinked elastomeric materials 4a–c are discussed. Inclusion of the diacetylene unit required synthesis of an appropriate monomeric species. 1,4‐Bis(dimethylaminodimethylsilyl)butadiyne [(CH 3 ) 2 N Si(CH 3 ) 2 CCCC(CH 3 ) 2 SiN(CH 3 ) 2 ] 2 was prepared from 1,4‐dilithio‐1,3‐butadiyne and 2 equiv of dimethylaminodimethylchlorosilane. The linear polymers were prepared via polycondensation of 2 with a series of disilanol prepolymers. The low molecular weight silarylene‐siloxane prepolymers 1a–c (terminated by hydroxyl groups) were synthesized via solution condensation of an excess amount of 1,4‐bis(hydroxydimethylsilyl)benzene with bis(dimethylamino)dimethylsilane. The linear polymers were characterized by 1 H and 13 C NMR, Fourier transform infrared spectroscopy, gel permeation chromatography, thermogravimetric analysis (TGA), and DSC. The elastomers exhibited long‐term oxidative stability up to 330 °C in air as determined by TGA. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part A: Polym Chem 40: 88–94, 2002
El residentado de Medicina en el Perú y en el Extranjero (2013)

Es indudable que no deja de causarnos una cierta admiración cuando tratamos de hacer una comparación entre el estado actual de la medicina, con sus tremendos avances, y con lo que sucedía décadas atrás cuando el médico sólo contaba con medios bastantes limitados. Pero no hay duda, también, que pese a lo dicho aún ahora asistirnos a una serie de discrepancias y estados verdaderamente conflictivos. Esto no solo específico e inherente a la realidad peruana dado que, aunque con otros matices, también se presentan en otros países. Dentro de este extenso universo quiero hacer algunos comentarios sobre la problemática del residentado médico.
The immune checkpoint molecule V-set Ig domain-containing 4 is an independent prognostic factor for multiple myeloma (2017)

Multiple myeloma (MM) remains as an incurable disease, despite recent substantial improvements in treatment. Therefore, development of novel biomarkers for risk stratification and new therapeutic targets are imperative. One of the emerging treatments for MM is the immune checkpoint blockades. V-set Ig domain-containing 4 (VSIG4) is a lately studied B7-related immune checkpoint modulator. We assessed the VSIG4 expression in patients with MM and its prognostic impact. We analyzed 81 bone marrow and 66 extramedullary biopsy samples of MM patients using immunohistochemistry. VSIG4 mRNA expression data from the Multiple Myeloma Genomics Portal (MMGP) were analyzed to validate our results. The overall survival (OS) of the high VSIG4 expression group was significantly poorer than that of the low VSIG4 expression group (<i>p</i> = 0.046). VSIG4 expression was remained statistically significant after adjustment for revised international staging system (rISS) and Mayo stratification algorithm (mSMART) risk classification, respectively (<i>p</i> = 0.019 and 0.017). Corroborating results were also observed on analyses of VSIG4 expression in patients with extramedullary MM and external data from the MMGP. Our results suggest that VSIG4 expression in MM is an independent indicator of poor prognosis, implying a possible therapeutic target for immunotherapy for MM.
Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies (2011)

Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport into tumor interstitium from the vascular compartment, and hindered transport through tumor interstitium to the target cells. Four major abnormal physical and physiological properties contribute to these transport barriers. Accumulated solid stress compresses blood vessels to diminish the drug supply to many tumor regions. Immature vasculature with high viscous and geometric resistances and reduced pressure gradients leads to sluggish and heterogeneous blood flow in tumors to further limit drug supply. Nonfunctional lymphatics coupled with highly permeable blood vessels result in elevated hydrostatic pressure in tumors to abrogate convective drug transport from blood vessels into and throughout most of the tumor tissue. Finally, a dense structure of interstitial matrix and cells serves as a tortuous, viscous, and steric barrier to diffusion of therapeutic agents. In this review, we discuss the origins and implications of these barriers. We then highlight strategies for overcoming these barriers by modulating either drug properties or the tumor microenvironment itself to enhance the delivery and effectiveness of drugs in tumors.
AMP-activated protein kinase: the guardian of cardiac energy status (2004)

Several years ago it was proposed that the AMP-activated protein kinase cascade might protect cells against stresses that deplete cellular ATP. Young et al. have now directly tested this by studying the effects of ischemia and reperfusion in perfused hearts from mice expressing a dominant-negative mutant that suppresses the kinase activity in cardiac muscle. Compared with control hearts, the mutant hearts showed clear evidence for increased necrotic damage and increased apoptosis. These findings may have implications for the treatment of ischemic heart disease.
Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation (2014)

Non-genetic phenotypic variations play a critical role in the adaption to environmental changes in microbial organisms. Candida albicans, a major human fungal pathogen, can switch between several morphological phenotypes. This ability is critical for its commensal lifestyle and for its ability to cause infections. Here, we report the discovery of a novel morphological form in C. albicans, referred to as the "gray" phenotype, which forms a tristable phenotypic switching system with the previously reported white and opaque phenotypes. White, gray, and opaque cell types differ in a number of aspects including cellular and colony appearances, mating competency, secreted aspartyl proteinase (Sap) activities, and virulence. Of the three cell types, gray cells exhibit the highest Sap activity and the highest ability to cause cutaneous infections. The three phenotypes form a tristable phenotypic switching system, which is independent of the regulation of the mating type locus (MTL). Gray cells mate over 1,000 times more efficiently than do white cells, but less efficiently than do opaque cells. We further demonstrate that the master regulator of white-opaque switching, Wor1, is essential for opaque cell formation, but is not required for white-gray transitions. The Efg1 regulator is required for maintenance of the white phenotype, but is not required for gray-opaque transitions. Interestingly, the wor1/wor1 efg1/efg1 double mutant is locked in the gray phenotype, suggesting that Wor1 and Efg1 could function coordinately and play a central role in the regulation of gray cell formation. Global transcriptional analysis indicates that white, gray, and opaque cells exhibit distinct gene expression profiles, which partly explain their differences in causing infections, adaptation ability to diverse host niches, metabolic profiles, and stress responses. Therefore, the white-gray-opaque tristable phenotypic switching system in C. albicans may play a significant role in a wide range of biological aspects in this common commensal and pathogenic fungus.