gebhart/patrepeval huggingface dataset:
Extracellular Matrix Promotes Rat Sertoli Cell Histotypic Expression In Vitro (1984)

We describe procedures for the preparation of a cell-free seminiferous tubule biomatrix, and provide evidence demonstrating that this material constitutes a useful substratum for maintaining the normal architecture of Sertoli cells in primary culture. Seminiferous tubule biomatrix, which has the morphological appearance of a fibrillar network rich in filaments and amorphous substance, is shown to consist of about 50% protein, most of which is collagen and glycoproteins. Fibronectin and laminin are also present in the seminiferous tubule biomatrix, as judged by immunofluorescence microscopy. Sertoli cell aggregates plated on this substratum retain a cuboidal to columnar shape, spread very slowly to form a monolayer, and survive for at least 3 weeks when cultured in a hormone-free, serum-free, chemically defined medium. In contrast, Sertoli cells plated onto uncoated polystyrene readily spread to form a monolayer of flat squamous cells which do not survive as well. Other morphological and ultrastructural characteristics are described which indicate that cells cultured on the seminiferous tubule biomatrix more closely resemble those of Sertoli cells in vivo than do cells plated on uncoated plastic. These differences in cell structure, including the maintenance of normal polarity as indicated by the presence of basolateral tight junctional complexes, remain evident for periods of 10 to 14 days after plating Sertoli cells onto biomatrix substratum. Rates of DNA synthesis by immature Sertoli cells plated onto biomatrix are less than rates by cells plated onto uncoated plastic. The data are discussed in relation to the role of substratum in the preservation of normal functions and histotype of Sertoli cells.
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals (1985)

The in vitro activity of five quinolone compounds, amoxicillin, and clindamycin against 118 strains of anaerobic bacteria isolated at community hospitals was determined by an agar dilution method. Nalidixic acid and cinoxacin had poor activity, and norfloxacin and enoxacin showed relatively poor activity. Ciprofloxacin was active against Bacteroides fragilis, Fusobacterium species, Clostridium perfringens, and gram-positive cocci. At peak levels achievable in the feces, norfloxacin and enoxacin had moderate activity.
Argifin, a New Chitinase Inhibitor, Produced by Gliocladium sp. FTD-0668. I. Taxonomy Fermentation, and Biological Activities. (2000)

A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain FTD-0668. The strain was identified as Gliocladium sp. from morphological characteristics. The IC50 value of argifin against Lucilia cuprina chitinase was 3.7 microM. Argifin arrested the moult of cockroach larvae upon injection into the ventral abdominal part.
Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling (2021)

Osteoarthritis (OA) is a common articular disease manifested by the destruction of cartilage and compromised chondrogenesis in the aging population, with chronic inflammation of synovium, which drives OA progression. Importantly, the activated synovial fibroblast (AF) within the synovium facilitates OA through modulating key molecules, including regulatory microRNAs (miR's). To understand OA associated pathways, in vitro co-culture system, and in vivo papain-induced OA model were applied for this study. The expression of key inflammatory markers both in tissue and blood plasma were examined by qRT-PCR, western blot, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assays. Herein, our result demonstrated, AF-activated human chondrocytes (AC) exhibit elevated NFκB, TNF-α, IL-6, and miR-21 expression as compared to healthy chondrocytes (HC). Importantly, AC induced the apoptosis of HC and inhibited the expression of chondrogenesis inducers, SOX5, TGF-β1, and GDF-5. NFκB is a key inflammatory transcription factor elevated in OA. Therefore, SC75741 (an NFκB inhibitor) therapeutic effect was explored. SC75741 inhibits inflammatory profile, protects AC-educated HC from apoptosis, and inhibits miR-21 expression, which results in the induced expression of GDF-5, SOX5, TGF-β1, BMPR2, and COL4A1. Moreover, ectopic miR-21 expression in fibroblast-like activated chondrocytes promoted osteoblast-mediated differentiation of osteoclasts in RW264.7 cells. Interestingly, in vivo study demonstrated SC75741 protective role, in controlling the destruction of the articular joint, through NFκB, TNF-α, IL-6, and miR-21 inhibition, and inducing GDF-5, SOX5, TGF-β1, BMPR2, and COL4A1 expression. Our study demonstrated the role of NFκB/miR-21 axis in OA progression, and SC75741's therapeutic potential as a small-molecule inhibitor of miR-21/NFκB-driven OA progression.
Coherent Backscatter In The Phase-Modulated Fibre Optic Gyroscope (1986)

This paper analyses on the effect of coherent backscatter on the output of the fibre optic gyroscope. By considering the phases and modulation efficiency of the backscatter beams, the analysis shows that Inertial Navigation performance should be able to be achieved by using relatively long coherence length sources, thus easing source wavelength stabilisation. The fundamental limit to the backscatter noise is shown to be due to the scattered components which are incoherent with the primary beams. The effect of the components which are coherent with the primary beams can be eliminated by use of the correct modulation frequency or polarisation control and tuning of the loop coupler.
Growth, food intake and energy balance of layer and broiler chickens offered glucose in the drinking water and the effect of dietary protein content (1989)

1. Four experiments were carried out to study the effect of offering a 91.5 g/l solution of glucose, compared to tap water, on fluid intake, food intake and growth of individually-caged immature chickens of both layer and broiler strains. 2. Male chicks of an egg-laying strain were offered glucose solution or tap water from 27 to 62 d after hatching. There was no effect of glucose on fluid intake but it depressed food intake (P less than 0.01) to give equal total energy intakes for each treatment. Body weight gain was reduced (P less than 0.001) and carcase fat content increased (P less than 0.001) by the glucose to yield no difference to total carcase energy. 3. When birds were placed in a respiration chamber for two 23-h periods there was no effect of treatment on outputs of energy as faeces + urine or as heat. 4. Male broilers were offered glucose solution or tap water with diets containing either 150 or 195 g protein/kg from 20 to 55 d after hatching. With the low-protein diet glucose depressed food intake (P less than 0.01) but total energy intake and carcase energy were not significantly affected. With the high-protein diet glucose did not depress food intake but increased total energy intake and total body fat. 5. Layer and broiler chicks were offered either a choice of the low- and high-protein diets or a single diet intermediate in protein content, with glucose solution or tap water. With broilers total food intake was depressed by glucose, mainly by a reduced intake of the low-protein diet. Intake of neither diet by the layer chicks was significantly affected by glucose. 6. It is concluded that provision of extra energy in glucose solution depresses food intake when the resultant energy:protein ratio becomes limiting. With a higher protein diet, or with birds having lower protein requirements, glucose solution does not depress food intake and increased fat deposition occurs.
Application of translation invariant wavelet de-nosing to axle of railway vehicles fault diagnosis online (2005)

The wavelet threshold method may produce fesndo-Gibbs phenomenon on the singularity points of signal. The transiation invariant wavelet is an improve method based on that algorithm. Comparing with threshold method, a translation invariance method can suppress Pesudo-Gibbs phenomenon and minish RMSE between the original signal and estimated one. At the same time, SNR of estimated signal can also be improved. This method is used to de-noise acoustic emission signals and compared with threshold method. The acoustic emission energy method is adopted to identify the fatigue cracks of axle of railway vehicle. The results demonstrate that this method can effectively eliminate noise, extract characteristic information of acoustic emission signals, is effective for online detectilon of the fault.
Relation between disturbance observer and model error compensator (2023)

This paper clarifies the relationship between the disturbance observer and the model error compensator. The model error compensator proposed by Okajima et al. (2013) compensates for the error between the output of the nominal plant model and the measurement outputs of the actual plant. On the other hand, the disturbance observer was first proposed to cancel out the effect of the disturbance by using the inverse model of the plant. Okajima et al. (2013) claim that the model error compensator differs from the disturbance observer because it does not use an inverse model, which is an advantage of the model error compensator. However, Ohnishi et al. (1996) proposed the Luenbergar observer-based disturbance observer, which does not use an explicit inverse model. Therefore, this paper shows that the disturbance observer is a type of model error compensator that uses a nominal model. Furthermore, it is shown that the observer gain of the disturbance observer determines the parameters of the model error compensator.
The effects of oral contraceptive usage on thrombin generation and activated protein C resistance in Saudi women, with a possible impact of the body mass index (2018)

As in other populations, our study demonstrated that OC usage induced prothrombotic changes in plasma of Saudi women, including resistance to the inhibitory actions of TM and APC. More specifically, OC usage in our population predominantly influenced TG and APC/TM sensitivity in overweight and obese individuals, a finding that needs confirmation in large cohort studies. The effects of APC and TM on TG parameters showed a positive association, and the correlation coefficients were higher in OC users for both ETP and peak values.
Techniques to improve the CLEAN deconvolution algorithm (1995)

The CLEAN algorithm was introduced in radio astronomy as a means to overcome the shadowing of small targets by the sidelobes of the point spread function (PSF) of a strong target. The idea was further used in microwave imaging where the concept of coherent CLEAN was introduced. The classical CLEAN algorithm is limited to a case where the targets are isolated. Techniques to overcome this limitation are presented in this paper. These techniques include PSF correlation to improve the estimation of target locations and intensities, sequence CLEAN (S-CLEAN) which improves the detection of true targets and suppresses the detection of false ones, and iterative CLEAN (ICLEAN) which uses knowledge about a target to improve the estimation of other targets' parameters. Emulation, using real experimental data, shows that a significant improvement can be achieved using these techniques.
P‐1: Optical Properties of Reflective LCD with Diffusive Micro Slant Reflectors (DMSR) (2000)

Abstract A reflective TFT‐LCD with an internal diffusive micro slant reflector (DMSR) is developed to improve the previous MSR structure. The DMSR structure is optimized to obtain a desired light scattering disbribution cone while still preserving the asymmetry characteristics. A 6.4″ VGA full‐color reflective TFT‐LCD with a DMSR is realized. In this paper, we will discuss the optical perperties of the panel. The measurement results show that the reflectance is 42% compared with a Lambertian white standard and the contrast ratio is larger than 20:1.
VOLATILE TERPENOID COMPOSITION OF ROSMARINUS OFFICINALIS, "CIM-HARIYALI": VARIABILITY IN NORTH INDIA DURING ANNUAL GROWTH (2012)

To investigate the seasonal influence on essential oil content and composition of rosemary (Rosmarinus officinalis) cultivar 'CIM-Hariyali' a study was conducted in Kumaon region of western Himalaya. Essential oil content was found to vary from 1.0% to 1.14% during the year. GC and GC-MS analyses enabled to identify thirty components representing 95.33% -97.03% of the total oil composition. Main components of the oils were 1,8-cineole (22.61% -23.85%), camphor (24.40% -25.85%), -pinene (10.74% -12.59%), verbenone (4.90% -5.77%), camphene (5.46% -6.16%), -pinene (3.28% -4.02%), limonene (2.86% -3.39%) and -myrcene (1.89% -1.95%). The study clearly showed that there were no drastic changes in the essential oil content and composition of rosemary due to season. Therefore, the crop may be harvested in any season to get good quality oil in hilly region of north India.
<title>Processing images and sounds with matching pursuits</title> (1995)

Complex signals need to be adaptively expanded over families of waveforms selected to match their different structures. A matching pursuit is a greedy algorithm that expands signals over vectors that are selected among redundant dictionaries of waveforms. The properties of this algorithm are reviewed. Applications to sound and image processing with dictionaries of time- frequency atoms are described.
Pest Status of the Brown Marmorated Stink Bug, Halyomorpha Halys in the USA (2012)

Since its initial discovery in Allentown, PA, USA, the brown marmorated stink bug (BMSB), Halyomorpha halys (Heteroptera: Pentatomidae) has now officially has been detected in 38 states and the District of Columbia in the USA. Isolated populations also exist in Switzerland and Canada. This Asian species quickly became a major nuisance pest in the mid-Atlantic USA region due to its overwintering behavior of entering structures. BMSB has an extremely wide host range in both its native home and invaded countries where it feeds on numerous tree fruits, vegetables, field crops, ornamental plants, and native vegetation. In 2010, populations exploded causing severe crop losses to apples, peaches, sweet corn, peppers, tomatoes and row crops such as field corn and soybeans in several mid-Atlantic states. Damaging populations were detected in vineyards, small fruit and ornamentals. Researchers are collaborating to develop management solutions that will complement current integrated pest management programs. This article summarizes the current pest status and strategies being developed to manage BMSB in the USA.
Simulation for stability of a beam-mass based high-resolution MEMS gravimeter (2022)

In this paper, stability and mechanistic simulations for a four-beam-mass-based MEMS gravimeter were conducted, and guidelines for the gravimeter design were proposed. Based on a prototyped MEMS device, the nonlinear finite element model was validated first against the experimental results. Then, we demonstrated three different scenarios in design that have three distinct modes of deformation: the mode with buckling (case 1), the mode without buckling but with a single zero-stiffness point (case 2), and the mode without both buckling and zero-stiffness point (case 3). Both case 1 and case 2 presented an unstable and sensitive region, in which a tiny perturbation could result in a rapid increase of the resonance frequency. Case 3, on the other hand, could provide a stable and low resonance frequency with a linear relationship between the displacement and gravitational acceleration. An optimized design of a beam/spring-mass-based relative gravimeter could be achieved using the above guidelines.
Houdini: A remote mobile platform for tank waste retrieval tasks (1996)

RedZone has developed Houdini{trademark}, a folding frame vehicle for work in waste storage tanks and other confined-access areas. Houdini is a tethered, hydraulically-powered platform that folds to fit through small openings. Once deployed, the vehicle unfolds to provide a substantial work platform for the deployment of a wide variety of tools. The Houdini system will perform wheel removal, waste retrieval, waste mobilization, waste size reduction, and other tank waste retrieval and decommissioning tasks. Within the DOE Complex, 332 underground storage tanks have been used to process and store radioactive and chemical mixed waste generated from weapon materials production. The ultimate goal of the program is to develop and commercialize the Houdini system for broad application throughout the DOE Complex.
Cooperative relaying for idle band integration in spectrum sharing systems (2013)

The scarcity of radio spectrum caused the emergence of spectrum sharing systems in which unlicensed users can exploit unused licensed primary bands. Due to unavailability of contiguous unused bands, services requiring large bandwidths can not be supported within unlicensed or cognitive networks. This could be overcome by using few disjoint idle bands and generating a larger bandwidth, also known as spectrum aggregation. In this paper, we analyze idle band integration in a cooperative network using multiple relays between a source-destination pair. We propose a simple protocol which allows some relays in the system to assist the source in aggregating a few idle bands through to the destination. As a whole, this enables the source-destination link to utilize a larger integrated bandwidth. We analyze amplify-and-forward (AF) and decode-and-forward (DF) relaying and derive a generalized closed form expression for the outage probability of the system applicable to both scenarios. We also investigate the system performance under different sets of conditions and discover some important tradeoffs.
Naive T-Cell Dynamics in Human Immunodeficiency Virus Type 1 Infection: Effects of Highly Active Antiretroviral Therapy Provide Insights into the Mechanisms of Naive T-Cell Depletion (2006)

Both naïve CD4+ and naïve CD8+ T cells are depleted in individuals with human immunodeficiency virus type 1 (HIV-1) infection by unknown mechanisms. Analysis of their dynamics prior to and after highly active antiretroviral therapy (HAART) could reveal possible mechanisms of depletion. Twenty patients were evaluated with immunophenotyping, intracellular Ki67 staining, T-cell receptor excision circle (TREC) quantitation in sorted CD4 and CD8 cells, and thymic computed tomography scans prior to and approximately 6 and approximately 18 months after initiation of HAART. Naïve T-cell proliferation decreased significantly during the first 6 months of therapy (P < 0.01) followed by a slower decline. Thymic indices did not change significantly over time. At baseline, naïve CD4+ T-cell numbers were lower than naive CD8+ T-cell numbers; after HAART, a greater increase in naïve CD4+ T cells than naïve CD8+ T cells was observed. A greater relative change (n-fold) in the number of TREC+ T cells/mul than in naïve T-cell counts was observed at 6 months for both CD4+ (median relative change [n-fold] of 2.2 and 1.7, respectively; P < 0.01) and CD8+ T cell pools (1.4 and 1.2; P < 0.01). A more pronounced decrease in the proliferation than the disappearance rate of naïve T cells after HAART was observed in a second group of six HIV-1-infected patients studied by in vivo pulse labeling with bromodeoxyuridine. These observations are consistent with a mathematical model where the HIV-1-induced increase in proliferation of naïve T cells is mostly explained by a faster recruitment into memory cells.
Differences in the O-Glycosylation Patterns Between Lung Squamous Cell Carcinoma and Adenocarcinoma (2002)

Mucins are highly O-glycosylated proteins synthesized by epithelial cells, and their glycosylation patterns can be altered during neoplastic transformation. The 2 types of non-small cell lung cancer (NSCLC) display a similar pattern of mucin gene expression but different reactivity to periodic acid-Schiff diastase, suggesting that a higher number of carbohydrate chains are present in adenocarcinomas. We compared the expression of core (Tn, sialyl-Tn, T) and terminal fucosylated and sialylated (Lewis antigens) carbohydrate structures in lung tumors. Specific antibodies were usedfor immunohistochemical and Western blot assays. Results indicated that core and terminal structures are detected more frequently in adenocarcinoma than in squamous cell carcinoma, except Lewis y, which is expressed strongly in both types of NSCLC. These data suggest that in squamous cell carcinoma and adenocarcinoma, different sets of glycosyltransferases must be expressed and that different posttranslational modifications of the mucin genes can take place in these 2 tumor types.
Design and optimization of 32 channel DWDM demultiplexer using 2-D slab photonic crystal (2005)

Demultiplexer design and optimization using a k-vector superprism is presented. We show that a 1.27 mm/sup 2/ square lattice on a typical SOI wafer is sufficient to resolve 32 channels with 100 GHz channel spacing.
Local Structure and Xenon Adsorption Behavior of Metal−Organic Framework System [M2(O2CPh)4(pyz)]n (M = Rh and Cu) As Studied with Use of Single-Crystal X-ray Diffraction, Adsorption Isotherm, and Xenon-129 NMR (2007)

The local structure and xenon adsorption behavior of a metal−organic framework system [M(II)2(bza)4(pyz)]n (bza and pyz = benzoate and pyrazine, M = Rh (1a) and Cu (1b)) were investigated by using single-crystal X-ray diffraction, xenon adsorption isotherm, and 129Xe NMR measurements. Single-crystal X-ray diffraction analysis revealed that rare gas atoms were accommodated in a one-dimensional (1D) nanochannel with the dimer structure. Xenon adsorption reached saturation at the xenon uptake of 1.93 Xe per molecular unit in 1a and of 1.85 Xe in 1b, suggesting accommodation of two Xe atoms per host formula unit. Analysis of the xenon adsorption isotherm based on the Fowler−Guggenheim equation gave the xenon−xenon interaction and the isosteric heat of adsorption. The 129Xe NMR spectrum suggested that the environment of the adsorption site for xenon in 1a is very tight and anisotropic. Furthermore, the temperature dependence of the 129Xe chemical shift was explained by using xenon loading, supporting the xenon dimer as the local structure of xenon in 1a. These aspects revealed that cooperative adsorption of xenon to 1a and 1b occurs according to the xenon−xenon interaction. Xenon is stabilized in the nanochannel through formation of a dimer structure.
Gd3+–Gd3+distances exceeding 3 nm determined by very high frequency continuous wave electron paramagnetic resonance (2017)

We present a fundamental study of a CW EPR lineshape analysis-based approach to determining Gd–Gd distances at very high frequencies (240 GHz). The approach is demonstrated from cryogenic to biologically-relevant temperatures.