gebhart/patrepeval huggingface dataset:
The Trichoderma atroviride putative transcription factor Blu7 controls light responsiveness and tolerance (2016)

Blu7 appears to regulate light sensitivity in terms of induction of conidiation, and to play a major role in supporting growth under continuous exposure to light. The diminished conidiation observed in ∆blu7 mutants is likely due to misregulation of the cAMP signaling pathway and ROS production, whereas their low tolerance to continuous exposure to light indicates that Blu7 is required for adaptation.
A Rapid Improvement of Heart Failure after Treatment of Hyperthyroidism (2012)

Background: Heart failure is a rare condition of thyrotoxicosis. We report a case of thyrotoxicosis-inducing heart failure. Case report: A 29-year old female had been suffered from thyrotoxicosis for 3 years without proper medication. She complained progressive dyspnea and palpitation with atrial fibrillation with rapid ventricular response. Marked cardiomegaly, and severe right ventricular dysfunction with biatrial enlargements were found on Two-dimensional (2D) echocardiography. We treated her with medications for heart failure and thyrotoxicosis, and the patient’s symptoms and objective cardiac functions are improved after two weeks. Conclusion: Severe heart failure caused by thyrotoxicosis could be reversible with proper management. Patients who have thyrotoxicosis should be assessed closely, and suitable treatment can markedly improve the patient’s prognosis.
On the performance of different HEMT cryogenic mixers (2002)

Performance of different HEMT mixers -i.e. gate, drain and resistive (microstrip and waveguide) has been studied experimentally at room and cryogenic temperatures. Conversion gain (loss for the resistive mixers) at cryogenic temperatures improves approximately 1/spl divide/1.5 dB. The noise figure improves too - all the mixers show 2-3 dB improvement in the noise figure performance.
Opioid agonist and antagonist activities of monofunctional nitrogen mustard analogs of .beta.-chlornaltrexamine (.beta.-CNA) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOpioid agonist and antagonist activities of monofunctional nitrogen mustard analogs of .beta.-chlornaltrexamine (.beta.-CNA)J. W. Schoenecker, A. E. Takemori, and P. S. PortogheseCite this: J. Med. Chem. 1987, 30, 5, 933–935Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jm00388a033https://doi.org/10.1021/jm00388a033research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells (1986)

We have isolated nearly full-length cDNA clones of terminal deoxynucleotidyltransferase (TdT) from calf thymus and mouse lymphoma cDNA libraries. The libraries were constructed using the pcD vector system which permits the expression of cDNA inserts in mammalian cells. The bovine TdT cDNA clone contains an open reading frame coding for 520 amino acids, Mr 59,678. The mouse TdT cDNA clone contains an open reading frame of 1,587 bp, whose translated cDNA encodes a 60,004 dalton protein. The mouse TdT cDNA clone contains 60 bp in the 3' end region of the coding sequence not found in the bovine TdT cDNA sequence, otherwise, the clones share about 80% homology. A possible nuclear-localization-sequence (Pro-Arg-Lys-Lys-Arg-Pro-Arg) was conserved in the N-terminal region in the mouse and bovine cDNA clones. Bovine and mouse cDNAs transfected into COS7 monkey fibroblasts directed the synthesis of enzymatically active protein of Mr 60,000 which was detected immunologically using polyclonal rabbit antibody against bovine TdT. Bovine TdT expressed in COS7 cells by nearly full-length cDNA clone was localized in the nucleus and the translational product of pOK103 lacking the nuclear-localization-sequence was localized in the cytoplasm.
Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b (2004)

Saccharomyces cerevisiae has been used as a model system to characterize the effect of cytochrome b mutations found in fungal and oomycete plant pathogens resistant to Q(o) inhibitors (QoIs), including the strobilurins, now widely employed in agriculture to control such diseases. Specific residues in the Q(o) site of yeast cytochrome b were modified to obtain four new forms mimicking the Q(o) binding site of Erysiphe graminis, Venturia inaequalis, Sphaerotheca fuliginea and Phytophthora megasperma. These modified versions of cytochrome b were then used to study the impact of the introduction of the G143A mutation on bc(1) complex activity. In addition, the effects of two other mutations F129L and L275F, which also confer levels of QoI insensitivity, were also studied. The G143A mutation caused a high level of resistance to QoI compounds such as myxothiazol, axoxystrobin and pyraclostrobin, but not to stigmatellin. The pattern of resistance conferred by F129L and L275F was different. Interestingly G143A had a slightly deleterious effect on the bc(1) function in V. inaequalis, S. fuliginea and P. megasperma Q(o) site mimics but not in that for E. graminis. Thus small variations in the Q(o) site seem to affect the impact of the G143A mutation on bc(1) activity. Based on this observation in the yeast model, it might be anticipated that the G143A mutation might affect the fitness of pathogens differentially. If so, this could contribute to observed differences in the rates of evolution of QoI resistance in fungal and oomycete pathogens.
Framework of the Tourism Comprehensive Service Platform Based on Blockchain Technology (2021)

Blockchain is considered to be one of the most promising transformational technologies in the era of digital economy, but it is still in the initial stage in tourism industry. Toward this end, in this paper, we put forward a systematic framework of tourism comprehensive service platform based on the blockchain technology. We first analyze the problems of the current tourism industry and the value of blockchain to it. Then, we introduce the proposed platform in detail, including its component modules and advantages. Lastly, we discuss the limitations and development trends of the platform. This paper is aimed at providing helpful guidance and reference for future research efforts.
Magnetic vascular implants promote rapid endothelialization. (2010)

Atherosclerosis is the most prevalent and costly public health threat in the world (WHO, 2006). Treatment often involves surgical placement of a vascular graft or stent, but these interventions are susceptible to thrombosis, inflammation, and neointimal hyperplasia in vivo. We designed and tested novel, rapidly-endothelializing, magnetic vascular grafts and stents. First, endothelial outgrowth cells endocytosed superparamagnetic microspheres in culture. The cells were then seeded onto magnetic stents and grafts for in vivo experimentation. Fourteen stents were implanted into pigs, showing superior resistance to inflammation, thrombosis, and neointimal hyperplasia relative to bare metal stents.&#13;\nSimilarly, endothelial cell coated cobalt chromium – poly(ether urethane) composite grafts were implanted into pig arteries, exhibiting improved patency at one month follow-up. These studies facilitated materials selection and design of cardiovascular implants with superior efficacy and reduced development time.
Using Drill Cutting Separates to Estimate the Strength of Narrow Shear Zones at SAFOD (2006)

[1] A technique is presented for estimating frictional strength of narrow shear zones based on hand selection of drillhole cuttings separates. Tests were conducted on cuttings from the SAFOD scientific drillhole near Parkfield, California. Since cuttings are mixed with adjacent material as they travel up the drillhole, these fault-derived separates give a better representation of the frictional properties of narrow features than measurements from the bulk material alone. Cuttings from two shear zones (one an active trace of the San Andreas fault) contain a significant weight percent of clay-rich grains that exhibit deformation-induced slickensides. In addition, cuttings from the active SAF trace contain around 1% serpentine. Coefficients of friction for clay-rich and serpentine grains were 0.3–0.5 and 0.4–0.45, respectively. These values are around 0.12 lower than the friction coefficient of the corresponding bulk cuttings, providing an improved estimate of the frictional strength of the San Andreas fault.
Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid (2013)

Selecting the right partner faster: In protein chemoselective conjugation, the use of levulinic acid for ketone introduction leads to slow oxime formation and poor yield because of internal cyclization, especially at low concentrations. A mechanism for cyclization is proposed and alternative keto-acids have been tested. These showed faster formation of oximes without side products. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Polystyrene Spherules in Coastal Waters (1972)

Polystyrene spherules averaging 0.5 millimeter in diameter (range 0.1 to 2 millimeters) are abundant in the coastal waters of southern New England. Two types are present, a crystalline (clear) form and a white, opaque form with pigmentation resulting from a diene rubber. The spherules have bacteria on their surfaces and contain polychlorinated biphenyls, apparently absorbed from ambient seawater, in a concentration of 5 parts per million. White, opaque spherules are selectively consumed by 8 species of fish out of 14 species examined, and a chaetognath. Ingestion of the plastic may lead to intestinal blockage in smaller fish.
Frequency-hopping versus interference cancellation for TD-CDMA (2000)

This work considers asynchronous time division code division multiple access (TD-CDMA) systems with RAKE receivers and one stage of parallel interference cancellation (PIC) or serial interference cancellation (SIC). A general method based on the concept of spherically symmetric signals is presented for the evaluation of the average probability of error of uncoded TD-CDMA systems. Slow frequency-hopping (SFH) with frequency overlap (FO) between adjacent carriers and interference cancellation are also included in the analysis, which considers the multipath Rayleigh fading channel (which models indoor and outdoor vehicular radio propagation). We analyze quadrature phase shift keying (QPSK) modulation with coherent demodulation and multipath (frequency) diversity with maximal ratio combining (MRC). Power control, adaptive SFH, and interference cancellation are employed for improving the bit-error rate (BER) performance. It is found that the scheme with SFH, in spite of the FO, always improves the performance substantially, and interference cancellation, in general, provides the highest BER improvement.
Rate of establishing the gut microbiota in infancy has consequences for future health (2015)

The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occur in the species prevalent in our guts. Although the sequential progression of these species is remarkably consistent across individuals and geographies, there is inter-individual variation in the rate of progression. Our study and others suggest that the rate is influenced by environmental factors, and influences our future health. In this article, we review our recent contribution to cataloging the developing infant gut microbiota alongside other important recent studies. We suggest testable hypotheses that arise from this synthesis.
Fused 1,2,6‐Thiadiazines Tetrahydrobenzo[b]thieno[2,3‐c] [1,2,6]thiadiazine 2,2‐Dioxides (1984)

Abstract Suitably substituted derivatives of tetrahydrobenzo[ b ]thiophene were treated with sulfamoyl chlorides to give sulfamoyl esters and nitriles. Ring closure of these compounds, under various conditions, afforded tetrahydrobenzo[ b ]thieno[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxides. Their herbicidal activities were tested.
High-Performance and Low-Cost 10-Gb/s Bidirectional Optical Subassembly Modules (2007)

High-performance and low-cost 10-Gb/s bidirectional optical subassembly (BOSA) modules that are obtained by adopting low-cost transistor outline (TO)-Can materials and processes are proposed and demonstrated. The BOSA module consists of an uncooled 1.3-mum distributed-feedback laser diode and a 1.5-mum p-i-n/transimpedance amplifier receiver (Rx), which integrate a 45deg tilted thin-film wavelength-division multiplexing filter to transmit a 1.3-mum light into the fiber and reflect a 1.55-mum light into the Rx. The matching resistor and low parasitic inductance packages are applied with the TO-Can laser diode to enable 10-Gb/s operation. A modulation bandwidth of 11.86 GHz and an OC-192 eye diagram of a 19% mask margin are obtained from the transmitter side. After a 10-km single-mode fiber (SMF) transmission, the mask margin for the OC-192 eye diagram decreases to 11%. For the Rx, an OC-192 eye diagram of a 31% mask margin is obtained under back-to-back connections. The mask margin is maintained at 29% after a 10-km SMF transmission. The measured crosstalk penalty is 0.9 d 15 at the Rx side. These results indicate that the BOSA module is capable of a 10-Gb/s bidirectional transmission. This unique high-performance 10-Gb/s BOSA module not only demonstrates the feasibility of a 10-Gb/s bidirectional transmission on an SMF for fiber-to-the-home applications but also shows the low-cost possibility to ensure the success of next-generation 10-Gb/s access networks.
Influence of the Substitution on Intramolecular Exciplex Formation between Pyrene and Indole Moieties (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of the Substitution on Intramolecular Exciplex Formation between Pyrene and Indole MoietiesNicole Helsen, Lucien Viaene, Mark Van der Auweraer, and Frans C. De SchryverCite this: J. Phys. Chem. 1994, 98, 6, 1532–1543Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://doi.org/10.1021/j100057a003Request reuse permissionsArticle Views190Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Supporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Static Relationship of Cycle Length to Reentrant Circuit Geometry (2001)

Correlation relationships derived from measurements using reentry and sinus-rhythm activation maps are useful to assess isthmus geometry on the basis of tachycardia cycle length. Such estimates may improve catheter ablation site targeting during clinical electrophysiological study.
Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes (1999)

Thimet oligopeptidase (TOP:E.C. 3.4.24.15) is a thiol sensitive metalloendopeptidase which is widely distributed and active in most tissues including testis, brain and pituitary. In the median eminence it is postulated to play a role in the degradation of GnRH released from the hypothalamus and thus to modulate LH levels. In the rat and human, the testis is the richest source of TOP activity with levels 3- to 5-fold higher than that of the brain. In order to define the exact localisation of this enzyme within the rat and human testis, the distribution of TOP in the developing and adult gonad was examined in situ and in isolated cells by immunohistochemistry, western blotting and northern blotting analysis. Ontogeny studies have demonstrated that TOP is detectable by western blotting from 9 days with levels of expression increasing with the age of the animal. Immunolocalisation of the protein in the interstitium was positive from 9 days onwards but was negative within the seminiferous tubules before 35 days of age, whereas TOP mRNA was not detected within the testis until 35 days of age with subsequent stable expression levels up to 90 days. In the adult rat testis, a strong TOP immunoreactivity was observed within seminiferous tubules, in elongating and elongated spermatids and residual bodies. In the interstitial compartment, immunoreactivity was also observed in Leydig cells and throughout the interstitial space. Western blot analyses confirmed the distribution of expression observed using immunochemistry, however Leydig cells display a lower signal than expected from the immunohistochemical data. Northern hybridization showed that the transcript is present in pachytene spermatocytes, early spermatids, and residual bodies, whereas its presence was not observed in Leydig cells probably due to very low levels of expression of the message. Analyses of various human tissue extracts showed that the testis displays the highest levels of TOP mRNA, with immunohistochemical experiments revealing that, as in the rat, the protein is principally expressed in elongated spermatids/residual bodies, and in Leydig cells. It is concluded that in the human and rat testes, TOP is highly expressed, in particular in post-meiotic germ cells and Leydig cells. The possible involvement of TOP in proteolytic events associated with the process of spermiogenesis and Leydig cell function is currently under investigation.
Cortisol Detection in Undiluted Human Serum Using a Sensitive Electrochemical Structure-Switching Aptamer over an Antifouling Nanocomposite Layer (2021)

There is a strong and growing need to monitor stress biomarkers <i>in vivo</i> for real-time emotional and wellness assessment. Toward this, we report a reagent-free electrochemical aptasensor with a nanocomposite antifouling layer for sensitive and continuous detection of cortisol in human serum. A thiolated, methylene blue (MB)-tagged conformation-switching aptamer was immobilized over a gold nanowire (AuNW) nanocomposite to capture cortisol and generate a signal proportional to the cortisol concentration. The signal is recorded through differential pulse voltammetry (DPV) and chronoamperometry. The aptasensor exhibited a sensitive response with 0.51 and 0.68 nM detection limits in spiked buffer and undiluted serum samples, respectively. Interference from other structurally similar analogs, namely, epinephrine and cholic acid, was negligible (<10%). The developed nanocomposite-based aptasensor showed excellent stability in undiluted human serum, outperforming several other nanocomposite materials even after prolonged exposure. This work lays the foundation for new biosensor formats such as implantable and wearable sensors.
In-vivo-Imaging von Hodgkin-Lymphomen mit monoklonalen Antikörpern (1989)

The Hodgkin- and Reed-Sternberg cell associated monoclonal antibody HRS-1 was labeled with radioactive iodine and injected into 6 patients with Hodgkin's lymphoma for immunoscintigraphic imaging. Four of five patients who received 131I-labeled HRS-1 had a positive immunoscintigram. In the sixth patient, the HRS-1 Mab was labeled with 123I in order to utilize tomoscintigraphy instead of linear scintigraphy. Bony disease was demonstrated by immunoscintigraphy in this patient. These preliminary results demonstrate that immunoscintigraphy with iodine-labeled HRS-1 Mab is feasible and informative in Hodgkin's lymphoma. The real clinical value of immunoscintigraphy in Hodgkin's lymphoma must be determined in a larger series of patients. Several modifications of the technique such as the use of Fab or F(ab')2 fragments should further improve the results.