gebhart/patrepeval huggingface dataset:
NBS Dynamic Seat Belt Tester (1966)

&lt;div class="htmlview paragraph"&gt;In line with the need for a suitable dynamic test procedure to determine the reaction of seat belt hardware and overall effectiveness of the seat belt or harness in constraining the vehicle occupant at various crash angles, a dynamic seat belt tester has been developed by the National Bureau of Standards. This tester was designed to provide a motion as stipulated by the proposed SAE dynamic specifications, and to reduce the cost, size, and power required in previously designed testers based on the sled principle. A progress report on the performance of this test device to date is given, including a description of its major components and general operation.&lt;/div&gt;
[Review of the international literature on the etiology of vertical root fractures]. (1990)

A throughfull literature review on vertical root fractures has been accomplished, analyzing in depth the causes of this frustrating clinical observation. Conclusions that can be of clinical importance have been reached.
Simulation Study on Coverage Path Planning of Autonomous Tasks in Hilly Farmland Based on Energy Consumption Model (2020)

The hilly farmland in China is characterized by small farmland areas and dense farmland distribution, and the working environment is three-dimensional topographic farmland, so the working conditions in the field are relatively complex. In this working environment, the coverage path planning technique of a farmland autonomous task is harder than that of 2D farmland autonomous task. Generally, the path planning problem of 2D farmland is to construct the path cost model to realize the planning of agricultural machinery driving route, while for the path planning problem of three-dimensional terrain farmland in the hilly region, this paper proposes a covering path planning scheme that meets the requirements of autonomous work. Based on the energy consumption model, the scheme searches the optimal driving angle of agricultural machinery, prioritizes solutions to the problem of covering path planning within the scattered fields in the working area, and then searches through the genetic algorithm for the optimal order of traversing the paths of each field to complete the coverage path planning in the working area. On the one hand, the scheme optimizes the planning route in the fields from the angle of optimal energy consumption; on the other hand, through the genetic algorithm, the fields are connected in an orderly manner, which solves the comprehensive problems brought by the unique agricultural environment and farming system in China’s hilly areas to the agricultural machinery operation. The algorithm program is developed according to the research content, and a series of simulation experiments are carried out based on the program using actual farmland data and agricultural machinery parameters. The results show that the planned path obtained at the cost of energy consumption has a total energy consumption of 4771897.17J, which is 17.4% less energy consumption than the optimal path found by the path cost search; the optimization effect is evident.
Glowbug, a Low-Cost, High-Sensitivity Gamma-Ray Burst Telescope (2020)

We describe Glowbug, a gamma-ray telescope for bursts and other transients in the 30 keV to 2 MeV band. It was recently selected for funding by the NASA Astrophysics Research and Analysis program, with an expected launch in the early 2020s. Similar in concept to the Fermi Gamma Burst Monitor (GBM) and with similar sensitivity, Glowbug will join and enhance future networks of burst telescopes to increase sky coverage to short Gamma-Ray Bursts (SGRBs) from binary neutron star (BNS) mergers, including possible SGRBs from NS-black hole mergers. With the recent discovery of the SGRB coincident with the gravitational wave transient GW170817, we know such events occur with reasonable frequency. Expanded sky coverage in gamma rays is essential, as more detections of gravitational waves are expected with the improved sensitivity of the upgraded ground-based interferometers in the coming years.
Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. (1998)

Angiostatin, a proteolytic fragment of plasminogen, inhibits the growth of primary and metastatic tumors by suppressing angiogenesis. When used in combination with ionizing radiation (IR), angiostatin demonstrates potent antitumor synergism, largely caused by inhibition of the tumor microvasculature. We report here the temporal interaction of angiostatin and IR in Lewis lung carcinoma (LLC) tumors growing in the hind limbs of syngeneic mice. Tumors with an initial mean volume of 510 +/- 151 mm3 were treated with IR alone (20 Gy x 2 doses on days 0 and 1), angiostatin alone (25 mg/kg/day divided twice daily) on days 0 through 13, or a combination of the two as follows: (a) IR plus angiostatin (days 0 through 13); (b) IR plus angiostatin (days 0 and 1); and (c) IR followed by angiostatin beginning on the day after IR completion and given daily thereafter (days 2 through 13). By day 14, tumors in untreated control mice had grown to 6110 +/- 582 mm3, whereas in mice treated with: (a) IR alone, tumors had grown to 2854 +/- 338 mm3 (P < 0.05 compared with untreated controls); and (b) angiostatin alone, tumors had grown to 3666 +/- 453 mm3 (P < 0.05 compared with untreated controls). In combined-treatment groups, in mice treated with: (a) IR plus longer-course angiostatin, tumors reached 2022 +/- 282 mm3 (P = 0.036 compared with IR alone); (b) IR followed by angiostatin, tumors reached 2677 +/- 469 mm3 (P > 0.05 compared with IR alone); and (c) IR plus short-course angiostatin, tumors reached 1032 +/- 78 mm3 (P < 0.001 compared with IR alone). These findings demonstrate that the efficacy of experimental radiation therapy is potentiated by brief concomitant exposure of the tumor vasculature to angiostatin.
Prevalence of zonulopathy in primary angle closure disease (2021)

This study evidenced a high prevalence of zonulopathy among a large cohort of PACD eyes and suggests zonulopathy as a possible under-recognised cause of angle closure. Until more sophisticated imaging modalities become available, awareness about the prevalence of zonulopathy in angle closure disease coupled with careful preoperative examinations can help minimise or prevent the complications of zonulopathy.
The influence of screening on the auger coefficient of 1.3 µm InGaAsP lattice matched to InP (1987)

We demonstrate numerically that calculations of the Auger coefficient of 1.3 μm InGaAsP are appreciably affected by the assumed screening parameters, especially at low temperatures and high carrier densities. We also generalize earlier theories of Auger processes to prove that the screening length should be set to infinity in such calculations.
Molecular Gradients of Bioinertness Reveal a Mechanistic Difference between Mammalian Cell Adhesion and Bacterial Biofilm Formation (2009)

Chemical gradients play an important role in guiding the activities of both eukaryotic and prokaryotic cells. Here, we used molecularly well-defined chemical gradients formed by self-assembled monolayers (SAMs) on gold films to reveal that mammalian cell adhesion and bacterial biofilm formation respond differently to a gradient of surface chemistry that resists cell attachment. Gradient self-assembled monolayers (SAMs) consisting of two mixed alkanethiols were fabricated by differential exposure of the gold film to one alkanethiol, followed by soaking in another alkanethiol solution. A gradient in bioinertness that resisted cell attachment was created on SAMs from a gradient in the surface density of HS(CH2)11(OCH2CH2)3OH, backfilled with either HS(CH2)11OH or HS(CH2)11CH3. Measurements of the amounts of mammalian cells and bacterial biofilms on these gradient surfaces reveal that, for mammalian cells, a critical density of adhesion ligands from absorbed proteins on surfaces exists for supporting maximum adhesion and proliferation, whereas for the bacterium Escherichia coli , the amount of biofilm formed on surfaces increased linearly with the surface density of adhesive groups (methyl or hydroxyl groups) in different media. These results are consistent with mammalian cell adhesion requiring an anchorage via specific molecular recognitions and suggest that biofilms can form by immobilization of bacteria via nonspecific interaction between bacteria and surfaces.
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin (2023)

Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
FitHiChIP: Identification of significant chromatin contacts from HiChIP data (2019)

FitHiChIP is a computational method for identifying chromatin contacts among regulatory regions such as enhancers and promoters from HiChIP/PLAC-seq data. <strong>Functionalities</strong> of FitHiChIP include: 1) Calling significant interactions / loops / contacts from a HiChIP / PLAC-seq data 2) Identifying peaks (enriched segments) from a HiChIP data (i.e. HiChIP peak caller) 3) Finding differential loops among non-differential loci between two different categories of HiChIP samples, each with one or more replicates. <strong>GitHub page</strong>: github.com/ay-lab/FitHiChIP <strong>Documentation</strong>: https://ay-lab.github.io/FitHiChIP/ <strong>Citation</strong>: Please check the above documentation regarding citation of FitHiChIP About this repository: All the data and results provided here correspond to the published manuscript. The file <strong>Data_Summary.xlsx</strong> summarizes for each figure, corresponding tables storing the related datasets.
New style (1921)

New style Get access C. Sanford Terry C. Sanford Terry 1Westerton of Pitfodels Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-VIII, Issue 145, 22 January 1921, Pages 68–69, https://doi.org/10.1093/nq/s12-VIII.145.68c Published: 22 January 1921
NucleusO26: A Barely Unbound System beyond the Drip Line (2016)

The unbound nucleus ^{26}O has been investigated using invariant-mass spectroscopy following one-proton removal reaction from a ^{27}F beam at 201 MeV/nucleon. The decay products, ^{24}O and two neutrons, were detected in coincidence using the newly commissioned SAMURAI spectrometer at the RIKEN Radioactive Isotope Beam Factory. The ^{26}O ground-state resonance was found to lie only 18±3(stat)±4(syst) keV above threshold. In addition, a higher lying level, which is most likely the first 2^{+} state, was observed for the first time at 1.28_{-0.08}^{+0.11} MeV above threshold. Comparison with theoretical predictions suggests that three-nucleon forces, pf-shell intruder configurations, and the continuum are key elements to understanding the structure of the most neutron-rich oxygen isotopes beyond the drip line.
Dynamic behavior and aggregation of propyllithium from carbon-13 and lithium-6 NMR at high field (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic behavior and aggregation of propyllithium from carbon-13 and lithium-6 NMR at high fieldGideon Fraenkel, Mark Henrichs, James M. Hewitt, Biing Ming Su, and Michael J. GeckleCite this: J. Am. Chem. Soc. 1980, 102, 10, 3345–3350Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ja00530a007https://doi.org/10.1021/ja00530a007research-articleACS PublicationsRequest reuse permissionsArticle Views636Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of Transactional Memory anomalies using static analysis (2010)

Transactional Memory allows programmers to reduce the number of synchronization errors introduced in concurrent programs, but does not ensures its complete elimination. This paper proposes a pattern matching based approach to the static detection of atomicity violation, based on a path-sensitive symbolic execution method to model four anomalies that may affect Transactional Memory programs. The proposed technique may be used to to bring to programmer's attention pairs of transactions that the programmer has mis-specified, and should have been combined into a single transaction. The algorithm first traverses the AST tree, removing all the non-transactional blocks and generating a trace tree in the path sensitive manner for each thread. The trace tree is a Trie like data structure, where each path from root to a leaf is a list of transactions. For each pair of threads, erroneous patterns involving two consecutive transactions are then checked in the trace tree. Results allow to conclude that the proposed technique, although triggering a moderate number of false positives, can be successfully applied to Java programs, correctly identifying the vast majority of the relevant erroneous patterns.
Iterative time reversal with tunable convergence (2011)

An iterative technique for improving the temporal focusing of a time reversal mirror is proposed and tested. A single amplification parameter is introduced to tune the convergence of the iteration. The tunable iterative technique has been validated by tests on an experimental electromagnetic time reversal mirror, as well as on a novel numerical model.
Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy (2011)

Rift Valley fever virus (RVFV), which causes hemorrhagic fever, neurological disorders or blindness in humans, and a high rate abortion and fetal malformation in ruminants, has been classified as a HHS/USDA overlap select agent and a risk group 3 pathogen. It belongs to the genus Phlebovirus in the family Bunyaviridae and is one of the most virulent members of this family. Several reverse genetics systems for the RVFV MP-12 vaccine strain as well as wild-type RVFV strains, including ZH548 and ZH501, have been developed since 2006. The MP-12 strain (which is a risk group 2 pathogen and a non-select agent) is highly attenuated by several mutations in its M- and L-segments, but still carries virulent S-segment RNA, which encodes a functional virulence factor, NSs. The rMP12-C13type (C13type) carrying 69% in-frame deletion of NSs ORF lacks all the known NSs functions, while it replicates as efficient as does MP-12 in VeroE6 cells lacking type-I IFN. NSs induces a shut-off of host transcription including interferon (IFN)-beta mRNA and promotes degradation of double-stranded RNA-dependent protein kinase (PKR) at the post-translational level. IFN-beta is transcriptionally upregulated by interferon regulatory factor 3 (IRF-3), NF-kB and activator protein-1 (AP-1), and the binding of IFN-beta to IFN-alpha/beta receptor (IFNAR) stimulates the transcription of IFN-alpha genes or other interferon stimulated genes (ISGs), which induces host antiviral activities, whereas host transcription suppression including IFN-beta gene by NSs prevents the gene upregulations of those ISGs in response to viral replication although IRF-3, NF-kB and activator protein-1 (AP-1) can be activated by RVFV7. Thus, NSs is an excellent target to further attenuate MP-12, and to enhance host innate immune responses by abolishing the IFN-beta suppression function. Here, we describe a protocol for generating a recombinant MP-12 encoding mutated NSs, and provide an example of a screening method to identify NSs mutants lacking the function to suppress IFN-beta mRNA synthesis. In addition to its essential role in innate immunity, type-I IFN is important for the maturation of dendritic cells and the induction of an adaptive immune response. Thus, NSs mutants inducing type-I IFN are further attenuated, but at the same time are more efficient at stimulating host immune responses than wild-type MP-12, which makes them ideal candidates for vaccination approaches.
A Geologist Goes to Desert Storm (1993)

(1993). A Geologist Goes to Desert Storm. Journal of Geological Education: Vol. 41, No. 1, pp. 43-51.
MDGRAPE-4: a special-purpose computer system for molecular dynamics simulations (2014)

We are developing the MDGRAPE-4, a special-purpose computer system for molecular dynamics (MD) simulations. MDGRAPE-4 is designed to achieve strong scalability for protein MD simulations through the integration of general-purpose cores, dedicated pipelines, memory banks and network interfaces (NIFs) to create a system on chip (SoC). Each SoC has 64 dedicated pipelines that are used for non-bonded force calculations and run at 0.8 GHz. Additionally, it has 65 Tensilica Xtensa LX cores with single-precision floating-point units that are used for other calculations and run at 0.6 GHz. At peak performance levels, each SoC can evaluate 51.2 G interactions per second. It also has 1.8 MB of embedded shared memory banks and six network units with a peak bandwidth of 7.2 GB s(-1) for the three-dimensional torus network. The system consists of 512 (8×8×8) SoCs in total, which are mounted on 64 node modules with eight SoCs. The optical transmitters/receivers are used for internode communication. The expected maximum power consumption is 50 kW. While MDGRAPE-4 software has still been improved, we plan to run MD simulations on MDGRAPE-4 in 2014. The MDGRAPE-4 system will enable long-time molecular dynamics simulations of small systems. It is also useful for multiscale molecular simulations where the particle simulation parts often become bottlenecks.
Unexpected Cross‐Coupling Reaction Between o‐Chloroaryl Ketones and Organomanganese Reagents. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Sequential and parallel fusion of detection and classification systems (2019)

This paper will investigate the fusion of various detection and classification systems. The architecture of combining these systems is the main interest of this work. We assume the detection and classification systems are known and they are legacy systems such that we know their receiver operating characteristic (ROC) functions, or their approximate ROC functions. Given an objective function we seek the optimal architecture that maximizes the objective function. Combining detection systems sequentially has been around for decades, especially in the bio-medical field where tests are preformed sequentially such that the outcome of one test will determine which test will be performed next. In military applications, we often use multiple detection systems in parallel and combine the outputs into a “fusion” center to determine the final answer. We conjecture that there might be a parallel and series mixture that would yield better performance. Part of determining this mixture is determining which systems go "where" in the mix. We investigate this architecture.
IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease. (1994)

We have recently demonstrated that a short course of high-dose IL-2 administered to lethally irradiated mice leads to marked protection from early and late GVHD mortality, especially when T cell-depleted (TCD) host-type bone marrow cells (BMC) are also administered. IL-2 inhibits the GVHD-inducing activity of donor CD4+ cells without inhibiting their graft-vs.-leukemia effects. Since CD4+ T-lymphocytes produce a variety of cytokines, some of which have recently been implicated in the pathogenesis of GVHD, we have studied the possible effect of IL-2 administration on serum levels of various cytokines. Acute GVHD was induced in lethally irradiated B10 mice by bone marrow transplantation (BMT) with MHC-mismatched allogeneic (A/J) BMC and splenocytes. TCD B10 (host-type) BMC were coadministered to maximize the protective effect of IL-2. Serum cytokine levels were compared in recipients of these inocula with or without a protective course of IL-2 treatment. A marked increase in serum IFN-gamma levels was noted on days 3 through 5 post-BMT in GVHD mice compared with syngeneic BMT control recipients. This GVHD-induced rise in serum IFN-gamma was markedly inhibited in IL-2-protected mice. Murine IL-2 levels were only slightly increased in sera of GVHD mice, and were not influenced by treatment with human recombinant IL-2. Serum levels of the monokines TNF-alpha and IL-1 alpha showed variable early elevations in GVHD mice with or without IL-2 treatment, and were not different from levels observed in syngeneic controls. Serum levels of IFN-gamma, IL-1 alpha, and TNF-alpha all declined markedly by day 7 to 8 post-BMT, when GVHD mortality begins. Administration of neutralizing anti-IFN-gamma mAb did not attenuate and tended to accelerate GVHD mortality, and administration of exogenous IFN-gamma did not overcome the protective effect of IL-2 against GVHD. Together, our results indicate that GVHD is associated with high serum levels of several proinflammatory cytokines in the first week post-BMT, but that these levels decline by the time when GVHD mortality begins. IL-2 specifically inhibits the GVHD-associated production of IFN-gamma, but this inhibition in itself does not explain and may even mitigate the protective effect of IL-2 against early GVHD mortality. However, the demonstration that IL-2 markedly inhibits the production of a GVHD-associated cytokine raises the possibility that alterations in the production of as yet undefined cytokines may be responsible for IL-2-induced GVHD protection.
Clinical utility of next‐generation sequencing in the diagnosis of hereditary haemolytic anaemias (2016)

Hereditary haemolytic anaemias are genetically and phenotypically heterogeneous disorders characterized by increased red cell destruction, with consequences ranging from innocuous to severe life-threatening anaemia. Diagnostic laboratories endeavour to assist clinicians reach the exact patient diagnosis by using tests principally based on morphological and biochemical techniques. However, these routine studies may be inconclusive, particularly in newborn infants and when transfusions have recently been administered. Large numbers and size of the potentially involved genes also impose a practical challenge for molecular diagnosis using routine sequencing approaches. To overcome these diagnostic shortcomings, we have utilized next-generation sequencing to provide a high-throughput, highly sensitive assay. We developed a panel interrogating 28 genes encoding cytoskeletal proteins and enzymes with sequencing coverage of the coding regions, splice site junctions, deep intronic and regulatory regions. We then evaluated 19 samples, including infants with unexplained extreme hyperbilirubinaemia and patients with transfusion-dependent haemolytic anaemia. Where possible, inheritance patterns of pathogenic mutations were determined by sequencing of immediate relatives. We conclude that this next-generation sequencing panel could be a cost-effective approach to molecular diagnosis of hereditary haemolytic anaemia, especially when the family history is uninformative or when routine laboratory testing fails to identify the causative haemolytic process.