gebhart/patrepeval huggingface dataset:
Ontogeny of gut morphology in the white shrimp Penaeus setiferus (Decapoda, Penaeidae) (1989)

Ontogeny of the gut in Penaeus setiferus was investigated by reconstruction of serial sections examined by light microscopy. Development of the gut into the adult form is protracted over several weeks beyond metamorphosis in steps that may be directly related to the unique postlarval life history of Penaeus. The gastric mill is lacking in larval stages of P. setiferus. In protozoeal stages Z<sub>1</sub> -Z<sub>3</sub> , the pyloric ampullae are blind sacs that do not communicate with the midgut. The gland filter first appears in mysis stage M<sub>2</sub> . The gastric mill in early postlarval (PL) stages consists of poorly chitinized lobes with flexible setae. By PL<sub>21</sub> the ossicles of the gastric mill are rigid and setae are replaced by spine-like denticles, but even by PL<sub>35</sub> the gastric mill is neither as massive nor heavily chitinized as in adults. During the mysis stages and early PL stages, the hepatopancreas communicates freely with both the foregut and the midgut trunk. By PL<sub>35</sub> the hepatopancreatic ducts are essentially isolated from the remainder of the midgut by foregut ossicles. The midgut in Z<sub>1</sub> consists of two pairs of simple caeca and the midgut trunk. During larval growth, each of the lateral midgut caeca develops into a number of lobes. After metamorphosis these lobes begin to ramify into small-diameter tubules, and by PL<sub>35</sub> have completely ramified into the hepatopancreas of adults. From M<sub>1</sub> to PL<sub>4</sub> , the anterior midgut caeca decrease in absolute size and become a single anterior diverticulum. The posterior midgut diverticulum first appears in PL<sub>21</sub> as a simple sac and thereafter increases in size and complexity.
Shallow water seakeeping tests with Columbia class submarine for integration into the Environmental Monitoring and Operator Guidance System (2020)

The Environmental Monitoring and Operation Guidance System (EMOGS) tool was developed in 1989 to provide a real-time risk analysis for underkeel clearance for the Ohio class submarine while in transit to the Naval Submarine Base at Kings Bay, Georgia. The program computes expected submarine response for input water level, depth, speed, wave, and other input conditions using shallow-water motion transfer functions generated by the strip theory tool, Large Amplitude Motion Program (LAMP). The integration of the new Columbia class submarine into EMOGS required that new transfer functions be developed using LAMP. The LAMP results are to be validated using measured motions from physical model laboratory testing. This report summarizes a laboratory study of the Columbia class submarine response in shallow-water waves. The study was conducted at the US Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory, and was done in direct
Performance Considerations for an Embedded Implementation of OMA DRM 2 (2005)

As digital content services gain importance in the mobile world, digital rights management (DRM) applications will become a key component of mobile terminals. The paper examines the effect dedicated hardware macros for specific cryptographic functions have on the performance of a mobile terminal that supports version 2 of the open standard for DRM defined by the Open Mobile Alliance (OMA). Following a general description of the standard, the paper contains a detailed analysis of the cryptographic operations that have to be carried out before protected content can be accessed. The combination of this analysis with data on execution times for specific algorithms realized in hardware and software has made it possible to build a model which has allowed us to assert that hardware acceleration for specific cryptographic algorithms can significantly reduce the impact DRM has on a mobile terminal's processing performance and battery life.
The Future of Inorganic Electrosynthesis Is Wide Open (2023)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Future of Inorganic Electrosynthesis Is Wide OpenStephen Maldonado*Stephen MaldonadoUniversity of MichiganMore by Stephen Maldonadohttps://orcid.org/0000-0002-2917-4851, Amy PrietoAmy PrietoColorado State UniversityMore by Amy Prietohttps://orcid.org/0000-0001-9235-185X, and Stanko BrakovicStanko BrakovicUniversity of HoustonMore by Stanko Brakovichttps://orcid.org/0000-0001-8250-8382Cite this: Acc. Chem. Res. 2023, 56, 13, 1685–1686Publication Date (Web):July 4, 2023Publication History Received18 May 2023Published online4 July 2023Published inissue 4 July 2023https://doi.org/10.1021/acs.accounts.3c00288Copyright © Published 2023 by American Chemical SocietyRIGHTS & PERMISSIONSArticle Views632Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (868 KB) Get e-AlertscloseSUBJECTS:Circuits,Coating materials,Electrosynthesis,Manufacturing,Materials Get e-Alerts
Abstract 4800: Pyruvate dehydrogenase inhibition leads to decreased glycolysis and increased reliance on asparagine in acute myeloid leukemia (2020)

Abstract Acute myeloid leukemia (AML) is an aggressive disease characterized by poor outcomes and chemotherapy resistance. Devimistat (CPI-613 ®) is a novel agent that inhibits two key tricarboxylic acid (TCA) cycle enzymes, pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes (KGDH). Our lab has shown that genetic and pharmacologic inhibition of PDH sensitizes cells to chemotherapy and recent clinical trials of chemotherapy plus devimistat have been promising. However, the means by which AML cells adapt to PDH loss during devimistat treatment is unknown. AML cells with PDH deleted by CRISPR-Cas9 (PDH KO) show decreased mitochondrial oxygen consumption, membrane potential and altered mitochondrial morphology. Surprisingly, PDH KO cells also showed decreased glycolytic rates. In order to explore this mechanism we assessed glucose uptake and found PDH KO cells had significantly less glucose uptake. We next assessed expression of hexokinase II, a key enzyme that commits glucose retention in the cell, in PDH KO and devimistat treated cells. Strikingly, we found that hexokinase II expression was decreased in PDH KO cells, which was rescued with proteasomal inhibition. Consistent with disruption of the protective interaction between mitochondrial membrane channel VDAC1 and HKII. However, PDH KO and devimistat treated cells are more sensitive to the glycolytic inhibitor 2-deoxy-D-glucose. This indicates that even though TCA cycle inhibition decreases glycolysis through loss of HKII, the cells are still reliant on the activity that remains. Cells can supplement TCA cycle intermediates through amino acid metabolism. Two key amino acids, asparagine and glutamate, were reintroduced to devimistat treated, amino acid starved, AML cells and asparagine significantly rescued the cells. Asparaginase, which converts asparagine into aspartic acid and ammonia, significantly increased sensitivity to genetic and pharmacological inhibition of PDH in AML cells. This indicates that glycolysis inhibition and amino acid deprivation in combination with devimistat-mediated PDH inhibition should be further explored in clinical trials. Citation Format: Rebecca Anderson, Kristin M. Pladna, Timothy S. Pardee. Pyruvate dehydrogenase inhibition leads to decreased glycolysis and increased reliance on asparagine in acute myeloid leukemia [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4800.
Quantitative Imaging of Selenium, Copper, and Zinc in Thin Sections of Biological Tissues (Slugs−Genus Arion) Measured by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (2007)

Quantitative imaging analysis of endogenous an exogenous elements throughout entire organisms is required for studies of bioavailability, transport processes, distribution, contamination and to monitor environmental risks using indicator organisms. An imaging mass spectrometric technique using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) was developed to analyze selenium and metal distributions in longitudinal sections (thickness, 100 microm) of entire slugs (genus arion). Slugs were fed with either a placebo or solutions containing 1000 microg mL(-1) Se. Samples (raster area, 25 mmx45 mm) were scanned together with synthetic matrix-matched standards with a focused beam of a Nd:YAG laser (wavelength, 266 nm; diameter of laser crater, 50 microm; laser power density, 3x10(9) W cm(-2)) in a large laser ablation chamber. The ablated material was transported with argon as carrier gas to the ICP ion source at a double focusing sector field ICPMS. Ion intensities of selenium (78Se+, 82Se+) were measured together with 13C+, 63Cu+, and 64Zn+ within the entire tissue section. The regression coefficient of the calibration curve was 0.998. Inhomogeneous distributions for Se but also for C, Cu, and Zn were found. Selenium was enriched in the kidney (150 microg g(-1) in Se-treated animals versus 15 microg g(-1) in the placebo-treated animal, respectively) and in the digestive gland (200 microg g(-1) versus 25 microg g(-1)). Highest Se concentrations were detected in the gut of Se-treated slugs (250 microg g(-1)), and additional Se occurred in the skin of these animals. Cu was enriched in the heart and the mucous ventral skin. Interestingly, in addition to the localization in the digestive gland, Zn was detected only in the dorsal skin but not the ventral skin. The developed analytical technique allows the quantitative imaging of selenium together with selected metals in thin sections of biological tissue with limits of detection at the submicrogram per gram range.
Feasibility of the Engager aortic transcatheter valve system using a flexible over-the-wire design (2012)

Application of the Engager™ TAVI system is safe and feasible. Prosthesis deployment in an anatomically correct position was facilitated by the design of the valve prosthesis and was successful in all patients. No device or delivery-system-related complications emerged. Safety and feasibility endpoints were met. Good results concerning the aortic valve performance after implantation and at 30-day follow up were ascertained. These results encouraged the start of a European Pivotal trial including patients to date.
Stability-Indicating HPLC Method for the Simultaneous Determination of Valsartan and Ezetimibe in Pharmaceuticals (2014)

Purpose: To develop a simple, accurate, sensitive, precise and robust reverse-phase HPLC stabilityindicating method for the simultaneous estimation of valsartan and ezetimibe in combined tablet formulation.Methods: A stability indicating method for the simultaneous estimation of valsartan and ezetimibe in combined tablet formulation using a RP-HPLC was developed and validated as per ICH guidelines using a symmetry C18 column with a mobile phase comprising phosphate buffer and acetonitrile (58:42 v/v, pH 3.15) with a flow rate of 0.8 mL/min at 230 nm. Stress degradation studies were performed in acidic, alkaline, oxidation and photolysis conditions to demonstrate the stability-indicating power of the method.Results: The contents of valsartan and ezetimibe were in the range of 99.77 ± 0.10 and 99.30 ± 0.43 % in the marketed formulation, 99.77 ± 0.08 and 99.29 ± 0.38 for the test formulation, respectively. The correlation coefficient for both valsartan and ezetimibe was 0.999 and recovery was in the range of 98 – 102 %. The limit of detection (LOD) was 0.2 and 0.3 μg/mL for valsartan and ezetimibe, respectively, while limit of quantification (LOQ) was 1 μg/mL for both valsartan and ezetimibe, respectively.Conclusion: The proposed method is simple, precise, accurate, reproducible, specific and reproducible used for the quantitative determination of valsartan and ezetimibe in bulk and dosage formulations.Keywords: Valsartan, Ezetimibe, Validation, Stability-indicating, Pharmaceuticals
JAXA2mx2m 遷音速風洞における境界層PIV 計測 (2015)

JAXA2mx2m 遷音速風洞における遷音速および超音速領域のParticle Image Velocimetry (PIV) を用いた境界層計測について紹介する．PIV の要素であるトレーサ粒子，撮像系，レーザシート系，処理手法を工夫することで，遷音速領域では約10mm，超音速領域では約1mm の境界層内部の速度分布を取得した．PIV の各要素の工夫点を紹介するとともに，遷音速領域のロケットフェアリングと超音速領域のフレア型円錐の計測結果を紹介する．
Fully Scalable Methods for Distributed Tensor Factorization (2016)

Given a high-order large-scale tensor, how can we decompose it into latent factors? Can we process it on commodity computers with limited memory? These questions are closely related to recommender systems, which have modeled rating data not as a matrix but as a tensor to utilize contextual information such as time and location. This increase in the order requires tensor-factorization methods scalable with both the order and size of a tensor. In this paper, we propose two distributed tensor factorization methods, CDTF and SALS. Both methods are scalable with all aspects of data and show a trade-off between convergence speed and memory requirements. CDTF, based on coordinate descent, updates one parameter at a time, while SALS generalizes on the number of parameters updated at a time. In our experiments, only our methods factorized a five-order tensor with 1 billion observable entries, 10 M mode length, and 1 K rank, while all other state-of-the-art methods failed. Moreover, our methods required several orders of magnitude less memory than their competitors. We implemented our methods on MAPREDUCE with two widely-applicable optimization techniques: local disk caching and greedy row assignment. They speeded up our methods up to 98.2× and also the competitors up to 5.9×.
Hämostasiologie (1982)

ZusammenfassungDie Pathogenese erworbener Thrombozytopathien ist bisher nur unzureichend aufgeklärt. Klinische Erfahrung zeigt, daß bei Patienten mit lokaler oder disseminierter intravasaler Gerinnung, wie sie z. B. im Rahmen einer Sepsis beobachtet wird, eine Störung der primären Blutstillung auftreten kann, die über das Maß der Thrombozytopenie hinausgeht. In den vorliegenden Untersuchungen wurden deswegen Thrombozyten in vitro mit Thrombin behandelt und funktionelle sowie biochemische Eigenschaften derartiger Plättchen bestimmt.
Comparison of Bone Grafts for Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis (2003)

Fusion rates were comparable for GroupA (ICBG) and Group C (composite graft of autologous bone marrow and demineralized bone matrix). The composite graft is our preferred graft for fusions in adolescent idiopathic scoliosis.
Novel germination inhibitors from Aegilops ovata L. (1977)

R. Cooper, E. C. Levy and D. Lavie, J. Chem. Soc., Chem. Commun., 1977, 794 DOI: 10.1039/C39770000794
The cyclisation of 1-bromo-19-methyl- and 1,19-dimethyl-1,19-dideoxybiladiene-ac dihydrobromides (1969)

The cyclisation of 1-bromo-1,19-dideoxy-19-methylbiladiene-ac dihydrobromides (I) bearing β-alkyl substituents to porphins in presence of a variety of one-electron oxidising agents has been shown to proceed at room temperature. Cyclisation of 1,19-dideoxy-1,19-dimethylbiladiene-ac dihydrobromides can be effected by cupric salts in boiling NN-dimethylformamide for 2 minutes. The alternative cyclisation of a variety of these salts in presence of nickel or cobalt salts yields the corresponding metal 1,19-disubstituted tetradehydrocorrins (VII) which are conveniently isolated as the perchlorates. Cyclisation of the nickel complex of a 1,19-dideoxy-1,19-dimethylbiladiene-ac in presence of ammonium ceric nitrate at room temperature also gave the corresponding nickel 1,19-dimethyltetra-dehydrocorrin salt (VIII).
Nonfaradaic Electrochemical Modification of the Catalytic Activity of Pt‐Black Electrodes Deposited on Nafion 117 Solid Polymer Electrolytes (1997)

The kinetics of oxidation by gaseous were investigated on a Pt‐black catalyst film also serving as a working electrode in a Nafion 117 solid polymer electrolyte cell. The Pt‐covered side of the Nafion 117 membrane was exposed to the flowing mixture and the other side was in contact with a 0.1 M KOH aqueous solution with an immersed Pt counterelectrode. It was found that the applied current and the catalyst‐electrode potential affect the catalytic rate of oxidation in a very pronounced and reversible manner. Positive currents enhance the rate of oxidation by up to 2000%. The increase in the rate of oxidation is up to 300 times larger than the electrochemical rate, I/2F, of oxidation. This shows that the catalytic properties of the Pt film are significantly modified by varying catalyst potential, as also manifested by the observed potential‐induced change in the functional dependence of the catalytic rate on the partial pressures of and . This novel application of solid polymer electrolytes to act as electrochemically activated catalyst supports, and thus promote and control heterogeneous catalytic reactions, is of considerable theoretical and possibly practical interest.
The Query Complexity of Scoring Rules (2014)

Proper scoring rules are crucial tools to elicit truthful information from experts. A scoring rule maps X, an expert-provided distribution over the set of all possible states of the world, and ω , a realized state of the world, to a real number representing the expert’s reward for his provided information. To compute this reward, a scoring rule queries the distribution X at various states. The number of these queries is thus a natural measure of the complexity of the scoring rule. We prove that any bounded and strictly proper scoring rule that is deterministic must make a number of queries to its input distribution that is a quarter of the number of states of the world. When the state space is very large, this makes the computation of such scoring rules impractical. We also show a new stochastic scoring rule that is bounded, strictly proper, and which makes only two queries to its input distribution. Thus, using randomness allows us to have significant savings when computing scoring rules.
TAMO: a flexible, object-oriented framework for analyzing transcriptional regulation using DNA-sequence motifs (2005)

TAMO (Tools for Analysis of MOtifs) is an object-oriented computational framework for interpreting transcriptional regulation using DNA-sequence motifs. To simplify the application of multiple motif discovery programs to genome-wide data, TAMO provides a sophisticated motif object with interfaces to several popular programs. In addition, TAMO provides modules for integrating motif analysis with diverse data sources including genomic sequences, microarrays and various databases. Finally, TAMO includes tools for sequence analysis, algorithms for scoring, comparing and clustering motifs, and several useful statistical tests. Recently, we have applied these tools to analyze tens of thousands of motifs derived from hundreds of microarray experiments.
Comparison of Recession Behavior between Lu<sub>2</sub>Si<sub>2</sub>O<sub>7</sub> and Lu<sub>2</sub>SiO<sub>5</sub> by High Speed Steam Jet at High Temperatures (2011)

The recession behavior of Lu2SiO5 and Lu2Si2O7 under high speed steam jet with a velocity of 50 m/s in temperature range between 1300o and 1500oC was compared. Material recession and porous microstructure were observed on the bulk surface for all samples after steam jet tests at the elevated temperatures. The porous structure for Lu2Si2O7 bulk samples become refine with increasing test temperature. On the other hand, the porosity of the porous structure for Lu2SiO5 bulk samples reduced with increasing test temperatures. Phase change was observed for the test of Lu2Si2O7 sample. Lu2SiO5 phase was formed on the Lu2Si2O7 bulk surface in the 1400oC test and Lu2Si2O7 phase was formed again on the surface of the bulk in the test at 1500oC. No phase change was observed in the tests for Lu2SiO5 between 1300o and 1500oC.
Cost Effective Laser Structuration of Optical Waveguides on Thin Glass Interposer (2017)

In order to enhance electro-optical system-in-package capabilities for silicon photonics, a cost effective fabrication process for optical waveguides integration on thin glass substrate interposer is demonstrated. First, a femtosecond laser ablation coupled with a hydrofluoric acid etching is developed to create microgrooves at the glass surface. Second, a dry film lamination followed by chemical mechanical planarization is achieved to define surface optical waveguides by filling the microchannels. Physical characterizations of the fabricated waveguides are performed using optical and scanning electron microscopy. Finally, optical mode profile and loss characterizations confirm the optical functionality of waveguides which prove to be multimodal at 1550 nm.
Fluoride‐induced enhancement and inhibition of photosynthesis in four taxa of Pinus (1988)

summary Pinus elliottii Englem. var. elliottii (PEE) and three varities of Pinus caribaea Morelet [var. caribaea Barr, et Golf. (PCC), var. bahamensis Barr. et Golf. (PCB) and var. hondurensis Bafr. et Golf (PCH)] were grown for a total of 125 days under gaseous hydrogen fluoride at 0.0, 1.2, 1.8.and 4.3 μg F m −3 . Apparent photosynthesis was measured on 10–12 plants in each taxon and treatment during the last 10 days of the experiment, using needles free from visible injury that had matured before (old) or during the experiment (young). Rates of apparent photosynthesis were significantly greater in young needles of PCB and PCH exposed to 1.2 than to 4.3 μg F m −3 , and in old needles of PCH exposed to 1.2 than to 0.0, 1.8 and 4.3 μg F m −3 . Chlorophyll concentrations in old needles were consistently lower than those in young needles, but varied less with changes in ambient fluoride concentration, differences in photosynthetic rates of PCB, PCC and PCH corresponded generally with differences in concentrations of chlorophylls a, b and (a+b). Ambient fluoride concentrations less than about 1 μg F m 3 appear unlikely to have deleterious short‐term effects on chlorophyll concentrations and photosynthesis in these taxa.
Design and testing of a high-temperature emissometer for porous and particulate dielectrics (1986)

A new, high-temperature (500–1500 °C) emissometer has been designed, assembled, and tested. The apparatus is unique in that it may be used to measure the emittance of media that are semitransparent and show substantial surface roughness, internal voidage, and/or chemical inhomogeneities throughout the emitting volume. Data reduction procedures are developed and an analysis of systematic error sources and experimental uncertainty is presented. The emittance of a high-purity alumina was measured at several temperatures in the wavelength range from 2 to 14 μm. Results are compared to published values.