gebhart/patrepeval huggingface dataset:
SYNTHESIS AND in vitro LEISHMANICIDAL AND CYTOTOXIC ACTIVITIES OF 2-STYRYLQUINOLINES ANALOGS (2008)

The search of new treatments for leishmaniasis is an active task nowadays, since there is a lack of nontoxic, cheap and non-resistant medication. In the literature several quinolines have shown in vitro activity against agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas diseases. Six 2-styrylquinolines derived from galipeine were synthesized by Perkin condensation of quinaldine with aromatic aldehydes. Leishmanicidal activity was estimated for Leishmania panamensis at the amastigote form and cytotoxic activity against U-937 cells. All compounds showed activity against both L. panamensis and U-937 cells. (E)-2-(2,5-dimethoxyphenyl)ethenyl)quinoline (1), (E)-2-(2,3- dimethoxyphenyl)ethenyl)quinoline (2) and (E)-N-[4-(2-quinolin-2-yl-ethenyl)phenyl]acetamide (3) were more active against axenic (EC50= 3.7, 4.5 and 19.1 μ g/mL) and intracellular amastigotes (EC50= 1.4, 1.8 and 1.7 μ g/ml, respectively), in comparison with hydrogenated derivatives 2-[2-(2,5-dimethoxy phenyl)ethyl]quinoline (1a) , 2-[2-(2,3-dimethoxyphenyl)ethyl]quinoline (2a) and N-[4-(2-quinolin- 2-ylethyl)phenyl]acetamide (3a) (CE50= 31.1, 23.6 and 59.3 μ g/mL, respectively). All compounds were also active against the U-937 cells. Styrylquinolines 1 , 2 and 3 showed a LC50 of 3.7, 6.2 and 4.5 μ g/mL, respectively and the hydrogenated derivatives 1a , 2a and 3a showed a LC50 of 16.0. 12.9 and 20.2 μ g/mL, respectively. Although hydrogenation reduced the leishmanicidal and cytotoxic activities, the activity showed against Leishmania parasites suggests this compound series has potential as drug candidates for the treatment of leishmaniasis.
Counter-propagating waves enhance maneuverability and stability: A bio-inspired strategy for robotic ribbon-fin propulsion (2012)

Weakly electric knifefish, Eigenmannia, are highly maneuverable swimmers. The animals rely on a long, undulating ribbon fin to generate propulsive force. During closed-loop control of hovering and station keeping, knifefish partition their fin to produce two inward counter-propagating waves, enabling them to hover and rapidly change direction. In response to moving objects or changes in ambient flow speed, the fish can actively modulate the nodal point where the two waves meet. During hovering, this nodal point is somewhere in the middle, but it can be moved forward or backward changing the relative force generated by the front and back portions of the fin. Although this strategy for thrust generation may be energetically inefficient, we show here that it enables rapid switching of swimming direction and produces a linear drag-like force that confers passive stability. Robotic results and simple computational simulations reveal that the net force generated by counter-propagating waves changes linearly with respect to the nodal position. Another strategy for reversing swim direction would be to completely reverse the direction of a single traveling wave. We show why full wave reversal (and similar strategies) may be ineffective for low-speed swimming &#x2014; a regime where counter-propagating waves may simplify control.
Limited hydrolysis of soy proteins with endo‐ and exoproteases (2004)

Abstract Changes in the native state and functional properties of soy protein achieved by limited proteolysis of soy flour were investigated. Different enzyme‐to‐substrate ratios (E/S) were used to obtain low (3–5%) and medium (5–10%) degrees of hydrolysis (DH). Six protease preparations (three with predominately exopeptidase activities and three with predominately endopeptidase activities) were evaluated, and their effects on solubility, emulsification capacity, SDS‐PAGE profiles, and denaturation enthalpies were characterized. Endoproteases (Multifect ® Neutral, Protex ™ 6L, and Multifect ® P‐3000) and exoproteases (Fungal Protease Concentrate, Experimental Fungal Protease #1, and Experimental Fungal Protease #2) yielded similar increases in soy protein solubility. The modifications to the soy peptide profile were similar for the three exoprotease mixtures at a 1% E/S ratio, whereas the extent of hydrolysis with Protex ™ 6L was more pronounced than with the two other endoproteases (Multifect ® Neutral and Multifect ® P‐3000). The emulsification capacity of protease‐modified soy flour declined regardless of DH and enzyme type (exo‐ or endoprotease). After hydrolysis to &gt;4% DH, denaturation enthalpies of glycinin and β‐conglycinin decreased significantly, whereas hydrolysis to lower DH did not affect these values.
34.4 A 256kb Sub-threshold SRAM in 65nm CMOS (2006)

Low-voltage sub-threshold operation has proven to minimize energy per operation for logic [1], and sub-threshold systems will require memories that function at the same low voltages. In this paper, a 65nm SRAM that functions into the sub-threshold region and examines the impact of process variation for low-voltage operation is described. Previous efforts to reduce SRAM power have included voltage scaling to the edge of sub-threshold [2] or into the sub-threshold region [3], but only for idle cells. Although some published SRAMs operate at the edge of sub-threshold, none function at sub-threshold supply voltages compatible with logic operating at the minimum energy point. The 0.18µm memory in [4] provides one exception. Consisting of latches and using MUX-based read (18T-equivalent bitcell), it operates to 180mV. Traditional 6T SRAMs face many challenges in deep submicron (DSM)
Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice: Comparison with Massive Sequencing (2016)

The unequivocal identification of hepatitis C virus (HCV) subtypes 1a/1b and genotypes 2 to 6 is required for optimizing the effectiveness of interferon-free, direct-acting antiviral therapies. We compared the performance of a new real-time HCV genotyping assay used on the Cobas 4800 system (C4800) with that of high-resolution HCV subtyping (HRCS). In total, 502 samples were used, including 184 samples from chronic HCV patients (from routine laboratory activity during April 2016), 5 stored samples with double HCV genotype infections for testing the limitations of the method, and 313 samples from a screening protocol implemented in our hospital (from May to August 2016) based on the new method to further determine its genotyping accuracy. A total of 282 samples, including 171 from April 2016 (the 13 remaining had too low of a viral load for HRCS), 5 selected with double infections, and 106 from screening, were analyzed by both methods, and 220 were analyzed only by the C4800. The C4800 correctly subtyped 125 of 126 1a/1b samples, and the 1 remaining sample was reported as genotype 1. The C4800 correctly genotyped 38 of 45 non-1a/1b samples (classified by HRCS), and it reported the remaining 7 samples as indeterminate. One hundred two of 106 non-1a/1b genotype samples that were identified using the C4800 for screening were confirmed by HRCS. In the 4 remaining samples, 3 were correctly reported as genotype 1 (without defining the subtype) and 1 was reported as indeterminate. None of the samples were misgenotyped. Four of 7 samples with double HCV infections were correctly genotyped by the C4800. Excluding the 5 selected double-infected samples, the C4800 showed 95.7% concordant results for genotyping HCVs 2 to 6 and 1a/1b subtyping, and 99.2% concordance for subtyping 1a/1b single infections in clinical samples. To improve laboratory workflow, we propose using the C4800 as a first-line test for HCV genotyping and 1a/1b classification, followed by transferring non-1a/1b samples to a center where HRCS is available, if further characterization is needed.
Biologically-inspired model of vision-based independently moving objects detection system (2007)

Vision-based independent motion detection systems have attracted a lot of attention lately. Such sort of system could be used in on-board automotive assistance system to help driver prevent possible collisions with other independently moving objects (IMOs). In this paper we present a biologically inspired model of IMOs detection system. The proposed model, according to a widely accepted in neuroscience hypothesis, consists of two information-processing streams: "what" (crucial for objects recognition) and "where" (responsible for independent motion discrimination).
SEM / EDS - a nearly universal tool for fly ash analysis? (2022)

Computer controlled SEM / EDS enables the unattended analysis of both the geometry and the chemical composition of thousands of individual particles. This method has been applied to a biomass fly ash. The correlations that can be derived from such measurements can help to understand the basic mechanisms of heavy metal deposition on fly ash particles as well as of deposition and corrosion mechanisms in boilers.
The Fabrication and Characterization of Piezoelectric PZT/PVDF Electrospun Nanofiber Composites (2016)

Piezoelectric nanofiber composites of polyvinylidene fluoride (PVDF) polymer and PZT (Pb(Zr0.53Ti0.47)O3) ceramics were fabricated by electrospinning. The microstructure of the PZT/PVDF electrospun nanofiber composites was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The tensile properties (stress-strain curves) and electrical properties (P-E hysteresis loops) of the PZT/PVDF electrospun nanofiber composites were investigated as a function of PZT content from 0 wt% to 30 wt%. The results demonstrated that a PZT content of 20 wt% had enhanced tensile and piezoelectric characteristics.
Component variations of polymers owing to the difference of charging process of dicyclopentadiene in synthesis of unsaturated polyesters. (1989)

endo-ジシクロベンタジエンを他の原材料と同時に配合する合成方法, ならびにポリエステル生成反応の途中から滴下する合成方法により, 無触媒で6種類の不飽和ポリエステルを合成した。合成方法の相違による生成ポリエステルの組成の変化を, 1H-NMRスペクトルを用いて解析した。ジシクロペンタジエンを同時に配合する場合は, 用いたジシクロペンタジエンの約72mol% が endo-exo 転位をともなってカルボキシル基の付加をうけ, ポリエステル鎖の末端にとり込まれたが, ヒドロキシル基の付加反応は認められなかった。付加したカルボキシル基は, 主としてマレイン酸の異性化によって生成したフマル酸のカルボキシル基であろうと推定した。また, 付加位置は exo-ジシクロペンタジエンの 5-位であって, 立体配置は exo-形であろうと推定した。そして, 約28mol%のジシクロベンタジエンはシクロペンタジエンに分解し, このシクロペンタジエンがフマル酸骨格に Diels-Alder反応によって付加し, trans-5-ノルボルネン-2,3-ジカルボン酸骨格を形成した。一方, 150℃以上の反応温度でジシクロペンタジエンを滴下した場合, ほとんどすべてのジシクロペンタジエンは trans-5-ノルポルネン-2,3-ジカルボン酸骨格に転化した。生成ポリエステルの化学成分の定量値に基づいてポリエステルの分子構造を推定し,セグメントの結合様式のモル比を算出した。
Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box (1996)

Bone-specific expression of the osteocalcin gene is transcriptionally controlled. Deletion analysis of osteocalcin promoter sequences by transient transfection of osseous (ROS 17/2.8) and nonosseous (R2 fibroblast) cells revealed that the most proximal 108 nucleotides are sufficient to confer tissue-specific expression. By gel mobility shift assays with wild-type and mutated oligonucleotides and nuclear extracts from several different cell lines we identified a novel transcription factor complex which exhibits sequence-specific interactions with the primary transcriptional element, the OC box (nt -99 to -76). This OC box binding protein (OCBP) is present only in osteoblast-like cells. Methylation interference demonstrated association of the factor with OC box sequences overlapping the Msx homeodomain consensus binding site. By assaying several mutations of the OC box, both in gel shift and transient transfection studies using ROS 17/2.8, we show the following. First, binding of OCBP correlates with osteocalcin promoter activity in ROS 17/2.8 cells. Increased binding leads to a 2-3-fold increase in transcription, while decreased binding results in transcription 30-40% of control. Second, homeodomain protein binding suppresses transcription. However, Msx expression is critical for full development of the bone phenotype as determined by antisense studies. Last, we show that one of the mutations of the OC box permits expression of osteocalcin in non-osseous cell lines. In summary, we demonstrate association of at least two classes of tissue-restricted transcription factors with the OC box element, the OCBP and Msx proteins, supporting the concept that these sequences contribute to defining tissue specificity.
Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees (2018)

Waves of highly infectious viruses sweeping through global honey bee populations have contributed to recent declines in honey bee health. Bees have been observed foraging on mushroom mycelium, suggesting that they may be deriving medicinal or nutritional value from fungi. Fungi are known to produce a wide array of chemicals with antimicrobial activity, including compounds active against bacteria, other fungi, or viruses. We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) and reishi (Ganoderma) fungi reduced the levels of honey bee deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-dependent manner. In field trials, colonies fed Ganoderma resinaceum extract exhibited a 79-fold reduction in DWV and a 45,000-fold reduction in LSV compared to control colonies. These findings indicate honey bees may gain health benefits from fungi and their antimicrobial compounds.
Can Enzymatic Activity, or Otherwise, Be Inferred from Structural Studies of Annexin III? (1997)

Annexin III, a putative inositol (1,2)-phosphohydrolase, was co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution. No enzyme active site was observed in the structure. Assays for enzymatic activity were also negative. Search for annexin III-inositol phosphate interactions using the BIAcoreTM system revealed an affinity for inositol cyclic (1,2)-phosphate, suggesting annexin III may sequester the molecule in the cell. The BIAcoreTM system used with different phospholipids showed that annexin III displays specificity for phosphatidylethanolamine, but not for phosphatidylinositols. Interestingly, a molecule of ethanolamine was found bound to the protein in the crystal structure. Coupled with the fact that this is a particularly abundant phospholipid in granules specific to neutrophils, cells where annexin III is highly expressed, our finding could be pointing to a physiological role of annexin III.
ZnO‐activated formation of phase pure perovskite Pb(In 1/2 Nb 1/2 )O 3 ‐Pb(Zn 1/3 Nb 2/3 )O 3 ‐PbTiO 3 powder (2019)

Abstract This paper reports on the phase formation of perovskite Pb(In 1/2 Nb 1/2 )O 3 ‐Pb(Zn 1/3 Nb 2/3 )O 3 ‐PbTiO 3 ( PIN ‐ PZN ‐ PT ) powder when doped with 0.04 to 0.83 mol% ZnO. Air calcination of undoped powder mixtures for 4 hours at 800°C resulted in a mixture of Pb 2 Zn 0.29 Nb 1.71 O 6.565 pyrochlore, PIN ‐ PZN ‐ PT perovskite, and In 2 O 3 . ZnO dopant concentrations as low as 0.04 mol% increased the rate of perovskite formation and resulted in near phase pure perovskite powder of 0.5 μm particle size when heated at 800°C in air. In all cases PbTiO 3 and Pb(In 1/2 Nb 1/2 )O 3 formed prior to PIN ‐ PZN ‐ PT formation. ZnO doping promotes perovskite phase formation by increasing the reactivity of the intermediate pyrochlore phase by substituting Zn 2+ on Nb 5+ sites and forming oxygen vacancies when heated in air. Heating in high resulted in an incomplete reaction and a mixture of perovskite and pyrochlore whereas low resulted in phase separation into a mixture of rhombohedral perovskite, tetragonal perovskite, and pyrochlore. The sensitivity clearly shows that oxygen vacancies due to ZnO‐doping are critical for synthesis of phase pure PIN ‐ PZN ‐ PT powder.
“Different strokes for different folks” (2012)

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Neuroprotective and antiinflammatory effects of extracts from in vitro cultivated Harpagophytum procumbens (devil's claw) (2009)

Harpagophytum procumbens, known as devil's claw, has been used traditionally for the treatment of pain, fevers, and dyspepsia. Recently, it has become popular for the treatment of rheumatoid and osteoarthritis. Most of the world's supply comes from Namibia, with lesser amounts from South Africa and Botswana. In 2002, the peak year of export, 1,018 tonnes of dried tubers were exported from southern Africa, representing the harvest of millions of plants. In 2000, recommendations were made to the Convention on the International Trade in Endangered Species (CITES) to add devil's claw to Appendix II. In 2004, the proposal was formally withdrawn due to the efforts of the range states to address sustainability issues. The governments of the main range states are working with local communities to develop policies and regulations to protect the species and to determine a sustainable harvest [1].
NMR spectra of iminobis(methylenephosphonic acid), HN(CH2PO3H2)2, and related ligands and of their complexes with platinum(II) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR spectra of iminobis(methylenephosphonic acid), HN(CH2PO3H2)2, and related ligands and of their complexes with platinum(II)Trevor G. Appleton, John R. Hall, and Ian J. McMahonCite this: Inorg. Chem. 1986, 25, 6, 726–734Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ic00226a005https://doi.org/10.1021/ic00226a005research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gradient based reverse ANN modeling approach for RF/microwave computer aided design (2012)

In this work, a new gradient based reverse modeling approach employing Artificial Neural Networks (ANNs) for systematic RF/microwave modeling is introduced. This approach is particularly suited to modeling scenarios, where standard ANN multi-layer perceptron (MLP) fails to deliver a satisfactory model. The proposed approach detects the simplest input-output relationship inherent to the modeling problem, which we term as the reverse model as compared to the original model (i.e., the modeling problem using standard ANN model). This reverse model is short-listed from a pool of candidate models obtained by systematically reversing the input-output variables of the original modeling problem, while retaining the ANN's structural simplicity. The proposed reverse and the not-so-Accurate original models complement each other to yield accurate models. The advantages of this approach are demonstrated via modeling transmission lines and spiral inductors. © 2012 European Microwave Assoc.
Framework for building intelligent mobile social applications (2012)

The use of online social networks (OSN) has been a reality for some years now. If OSN users have mobile devices and they are taken into account, every day a vast amount of information is spontaneously generated, creating opportunities for researchers and developers to use, for example, artificial intelligent techniques to explore similarities between friends, to recommend content and to come up with business opportunities. Additionally, OSN and mobile devices can be put together to explore user context to tailor services according to the user environment. However, to apply ubiquitous computing and artificial intelligence to OSN can be cumbersome and resource-consuming. Thus, this paper presents a framework to develop intelligent applications on top of existing OSN, helping developers to explore similarities between the users and recommend content, using user context and simple information present on OSN, without compromising resources present in mobile devices. At the end, this paper shows how to develop new applications using the framework exploring user context and semantic concepts defined by the developer.
Fréquence et facteurs de risque des Smur de seconde intention dans les intoxications médicamenteuses volontaires (2013)

Les intoxications médicamenteuses volontaires (IMV) sont une situation fréquente en régulation médicale et en Smur. Plusieurs études semblent indiquer que la régulation médicale des IMV n’est pas performante. Nos objectifs étaient d’étudier les Smur de seconde intention en tant que critère de qualité de la régulation et d’identifier les facteurs de risque de Smur de seconde intention. Étude rétrospective, monocentrique, du 1er janvier 2008 au 31 décembre 2010. Les patients majeurs pris en charge en Smur pour IMV et admis dans un hôpital universitaire étaient inclus. Une analyse univariée puis une régression logistique multiple étaient planifiées pour comparer les données épidémiologiques et toxicologiques entre les patients bénéficiant de l’envoi immédiat ou secondaire d’une ambulance médicalisée. Trois cent douze patients étaient inclus dont 69 % de femmes. L’âge médian était de 45 [35; 53] ans. Le Smur était envoyé en première intention pour 131 patients (41 %). Les patients pris en charge secondairement par un Smur étaient plus souvent intubés (n = 67 [47 %] vs n = 111 [61 %], p = 0,001) et admis en réanimation (n = 87 [66 %] vs n = 147 [81 %], p = 0,001). Aucun critère épidémiologique ou toxicologique n’était un facteur de risque de Smur de seconde intention. Le Smur est secondairement déclenché dans plus de la moitié des IMV et est associé à des mesures de réanimation plus fréquentes. Les décisions d’envoi du Smur en seconde intention ne sont pas expliquées par des critères épidémiologiques ou toxicologiques.
HLA‐DR4 predicts haematological response to cyclosporine in T‐large granular lymphocyte lymphoproliferative disorders (2003)

T-cell large granular lymphocytic lymphoproliferative disease (T-LGL) is often associated with life-threatening cytopenias. Twenty-five subjects with anaemia and/or neutropenia caused by T-LGL were treated with cyclosporin A (CSA) 5-10 mg/kg/d for at least 3 months. Eighteen patients survived between 35 and 77 months after starting treatment. Fourteen patients [56%; 95% confidence interval (CI) 35-76%] responded to CSA with sustained improvement in the neutrophil count or transfusion independence. Seven had complete normalization of blood counts, and four achieved a durable response only after the addition of erythropoietin. Sustained response required continued low-dose CSA. In a multivariate analysis, HLA-DR4 was highly predictive of CSA responsiveness (odds ratio 18; 95% CI 1.8-184). T-LGL subtype, LGL counts after therapy, lymphocytic marrow infiltration and bone marrow cellularity did not significantly affect the probability of response. We conclude that CSA is effective in inducing haematological responses in HLA-DR4-positive patients and that T-LGL is likely to have an immune pathogenesis.