gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Diels‐Alder Reactions with Diacceptor‐Substituted Methylenecyclopropanes ‐ A New Aspect for the Twofold Nucleophilic Substitution at Cyclopropanes. (1989)

Abstract The highly reactive (diacylmethylene)cyclopropanes (II), generated from the cyclopropane (I) and acetyl chloride, are trapped by dienes such as (III) to give the adducts (IV).
A review of research into second intention equine wound healing using manuka honey: Current recommendations and future applications (2015)

Summary In addition to the generic properties of honey, manuka honey has a nonperoxide antimicrobial activity largely attributed to methylglyoxal. Commercially, manuka honey is graded against a standard antiseptic, phenol, to provide a measure of antimicrobial activity referred to as the unique manuka factor ( UMF ). The higher the UMF , the greater the antimicrobial activity. However, more recently, there is evidence that manuka honey can also modulate the initial inflammatory response through activation of toll‐like receptor 4 on monocytes to enhance production of cytokines important in tissue repair and regeneration. Recent studies investigating the effects of manuka honey on second intention healing of lower limb wounds in horses have shown that wounds treated with UMF 20 manuka honey retracted less and healed faster than untreated wounds. Using this wound healing model, the primary effects of manuka honey appeared to be associated with the modulation of the initial inflammatory reaction rather than its antimicrobial effects. Based on the current knowledge, treatment with manuka honey should be instituted as soon as possible after injury. Where bacterial contamination is substantial, manuka honey with a UMF ≥15 should be used. While bandages will improve the contact between the honey and the wound and may be indicated in the early stages of wound healing, prolonged bandaging may lead to the production of excessive granulation tissue. If topical treatment without a bandage is to be used, more honey is not necessarily better. Using a thin film combined with regular application, contact times may be optimised. Application 2–3 times daily to open wounds may improve efficacy. Manuka honey should be applied for at least 21 days after wounding but there may be beneficial effects if it is applied until wound healing is almost complete.
Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction (2012)

Hypoxia-inducible factor 1α (HIF1α) induction in adipocytes is a critical component of the "fibrotic response," directly linked to metabolic dysfunction in adipose tissues under hypoxic conditions. We reasoned that inhibition of HIF1α may ameliorate the negative aspects of the obesity-associated fat pad expansion. We used the selective HIF1α inhibitor PX-478, whose effectiveness has previously been established in tumor models. We demonstrate that PX-478 treatment effectively suppresses the high-fat-diet (HFD)-induced HIF1α activation in adipose tissue. HIF1α inhibition causes a reduction of weight gain in mice on an HFD but not on a chow diet. Treatment increases energy expenditure and prompts resistance to HFD-mediated deterioration of metabolic parameters. Moreover, PX-478-treated mice have reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues. We confirm the metabolic effects obtained with PX-478 treatment using an adipose tissue-specific, doxycycline-inducible dominant negative HIF1α mutant (dn-HIF1α). Consistent with the pharmacological results, genetic inhibition of endogenous HIF1α activity prompts similar metabolic improvements in HFD-fed mice. Collectively, our results demonstrate that HIF1α inhibition in the adipocyte leads to significant metabolic improvements, suggesting that selective HIF1α inhibition in adipose tissue may be an effective therapeutic avenue in the context of metabolic dysfunction.
Chapter 8. The structure, characterization, and evolution of colloidal metals (1990)

A. I. Kirkland, P. P. Edwards, D. A. Jefferson and D. G. Duff, Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 1990, 87, 247 DOI: 10.1039/PC9908700247
Fluorescence diagnosis and photochemical treatment of diseased tissue using lasers: Part I (1989)

Lasers are useful in many applications in medicine and biology. Historically, most laser use has involved heat generated in the interaction of the laser beam with the tissue. Today, however, the spectroscopic aspects of this laser use are playing a more dominant role in a number of applications. In this two-part series, Sune Svanberg and co-workers present illustrations of emerging clinical applications from cooperative work performed by the Lund Institute of Technology and the Lund University Hospital. Part I includes a survey of laser techniques for atomic and molecular analyses of samples of medical interest, spectroscopic analysis of the laser-induced plasma obtained when a high-power pulsed laser beam interacts with tissue, and the use of tumor-seeking agents in combination with laser radiation to provide new possibilities for malignant tumor detection and treatment. Part II, which will appear in the January 1, 1990, issue, describes the use of laser-induced fluorescence for tumor and plaque diagnostics. Different lasers have been used, and research efforts increasingly are being focused on excimer lasers and lasers in the IR region for the ablation of atherosclerotic plaques, cell layer by cell layer.
Seven novel species of Acinetobacter isolated from activated sludge (2003)

Thirteen isolates of Acinetobacter were obtained from activated sludge plants in Victoria, Australia. Earlier 16S-23S rDNA genomic fingerprinting and partial 16S rDNA sequence data had suggested that these isolates might contain previously undescribed species. This view was confirmed here. A polyphasic taxonomic approach involving phenotypic characterization, near-complete 16S rDNA sequence data and DNA-DNA hybridization analyses support the view that seven novel genomic species can be differentiated in this group of isolates. However, when fluorescence in situ hybridization (FISH) studies were performed with a 16S-rRNA-targeted probe specific for the genus Acinetobacter, used to identify Acinetobacter in activated sludge plants, all these strains responded positively. This suggests that these isolates would not have been missed in earlier FISH studies where their role as polyphosphate-accumulating bacteria has been questioned. This report describes these isolates and proposes that they be named Acinetobacter baylyi (type strain B2T = DSM 14961T = CIP 107474T), Acinetobacter bouvetii (type strain 4B02T = DSM 14964T = CIP 107468T), Acinetobacter grimontii (type strain 17A04T = DSM 14968T = CIP 107470T), Acinetobacter tjernbergiae (type strain 7N16T = DSM 14971T = CIP 107465T), Acinetobacter towneri (type strain AB1110T = DSM 14962T = CIP 107472T), Acinetobacter tandoii (type strain 4N13T = DSM 14670T = CIP 107469T) and Acinetobacter gerneri (type strain 9A01T = DSM 14967T = CIP 107464T).
Enhancement of Zika Infection by Dengue-Specific Antibodies Does Not Alter the Production of Interleukin 6 in FcγRII-Expressing K562 Cells (2017)

Fundação Oswaldo Cruz. Centro de pesquisa Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciência Médica. Instituto de Ciência Biológica. Recife. PE. Brasil.
LplA1‐dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence (2007)

The bacterial pathogen Listeria monocytogenes replicates within the cytosol of mammalian cells. Mechanisms by which the bacterium exploits the host cytosolic environment for essential nutrients are poorly defined. L. monocytogenes is a lipoate auxotroph and must scavenge this critical cofactor, using lipoate ligases to facilitate attachment of the lipoyl moiety to metabolic enzyme complexes. Although the L. monocytogenes genome encodes two putative lipoate ligases, LplA1 and LplA2, intracellular replication and virulence require only LplA1. Here we show that LplA1 enables utilization of host-derived lipoyl peptides by L. monocytogenes. LplA1 is dispensable for growth in the presence of free lipoate, but necessary for growth on low concentrations of mammalian lipoyl peptides. Furthermore, we demonstrate that the intracellular growth defect of the DeltalplA1 mutant is rescued by addition of exogenous lipoic acid to host cells, suggesting that L. monocytogenes dependence on LplA1 is dictated by limiting concentrations of available host lipoyl substrates. Thus, the ability of L. monocytogenes and other intracellular pathogens to efficiently use host lipoyl peptides as a source of lipoate may be a requisite adaptation for life within the mammalian cell.
Interleukin-6 ( IL-6 ) and the Prognosis of Abdominal Aortic Aneurysms (2001)

Aortic aneurysms appear to be an important source of circulating IL-6, the concentration being influenced by genotype. For patients with small aneurysms, the -174 G-->C IL-6 genotype predicts future cardiovascular mortality.
Conserved synteny and gene order difference between human chromosome 12 and pig chromosome 5 (2001)

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access
Aerodynamics of Cascades (Aerodynamik der Schaufelgitter), (1977)

Contents: Fundamental Fluid Mechanics Principles of Turbomachines; The Rectilinear Cascade with Small Blade Spacing; The Rectilinear Cascade with Large Blade Spacing; The Rectilinear Cascade with Arbitrary Solidity; The Rectilinear Cascade with Arbitrary Solidity and Arbitrary Profile Shape; Viscous Effects in Rectilinear Cascades; Compressible Two-Dimensional Cascade Flow; High-Lift Devices; and Developments During the Last Decade.
A Gain of Superoxide Dismutase (SOD) Activity Obtained with CCS, the Copper Metallochaperone for SOD1 (1999)

The incorporation of copper ions into the cytosolic superoxide dismutase (SOD1) is accomplished in vivo by the action of the copper metallochaperone CCS (copper chaperone for SOD1). Mammalian CCS is comprised of three distinct protein domains, with a central region exhibiting remarkable homology (approximately 50% identity) to SOD1 itself. Conserved in CCS are all the SOD1 zinc binding ligands and three of four histidine copper binding ligands. In CCS the fourth histidine is replaced by an aspartate (Asp(200)). Despite this conservation of sequence between SOD1 and CCS, CCS exhibited no detectable SOD activity. Surprisingly, however, a single D200H mutation, targeting the fourth potential copper ligand in CCS, granted significant superoxide scavenging activity to this metallochaperone that was readily detected with CCS expressed in yeast. This mutation did not inhibit the metallochaperone capacity of CCS, and in fact, D200H CCS appears to represent a bifunctional SOD that can self-activate itself with copper. The aspartate at CCS position 200 is well conserved among mammalian CCS molecules, and we propose that this residue has evolved to preclude deleterious reactions involving copper bound to CCS.
3‐Funtionalized Tetronic Acids from Domino Rearrangement/Cyclization/Ring‐Opening Reactions of Allyl Tetronates. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Negative ion sources for high energy accelerators (invited) (2000)

Due to the development of reliable H− ion sources, charge-exchange injection into circular accelerators has become routine. For preacceleration of heavy ions tandem generators with a stripping foil are used in order to double the energy with the same high voltage. This article reviews recent developments in negative hydrogen ion sources. The underlying physics, operating parameters, and beam characteristics of selected sources will be described and compared.
<p>Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy</p> (2019)

<b>Introduction:</b> Acute myeloid leukemia (AML) remains a disease with high mortality, especially for older patients and those with relapsed/refractory (R/R) disease. With recent advances in molecular testing, targeting particular leukemogenic mutations such as those occurring in isocitrate dehydrogenase (IDH) became possible. Enasidenib is a new small-molecule inhibitor of mutant isocitrate dehydrogenase-2 (IDH2). <b>Aim:</b> The objective of this article is to review the evidence for the use of enasidenib in R/R AML, as well as to outline future directions of enasidenib therapy. <b>Evidence Review:</b> Enasidenib was approved in August 2017, after a successful Phase I/II trial showing an overall response rate (ORR) of 40.3% in R/R disease, with 19.3% of patients achieving complete remission (CR). Enrollees in the trial were mostly older adults. The most prominent toxicities were hyperbilirubinemia and IDH-differentiation syndrome (IDH-DS), though the drug was generally well tolerated and the maximum tolerated dose was not reached. A Phase III trial is currently ongoing. <b>Conclusion:</b> Enasidenib provides a new therapeutic option for patients with R/R AML. Further studies are ongoing to ascertain its role in combination with other agents and newly diagnosed disease.
Neutron small-angle scattering: experimental techniques and applications (1974)

The use of neutrons in small-angle scattering has opened a wide field of applications for investigations in magnetism, polymeric science, for certain problems in biology, and in metallurgy. In the first part, this review deals with the experimental aspects of neutron small-angle scattering. In particular, the compensation of the relatively small luminosity of neutron sources as compared to X-ray tubes will be discussed in detail. This is mainly achieved by large beam cross sections, leading to correspondingly long instruments, and by an optimization of the intensity with respect to the different contributions to the resolution width of the scattering vector κ(κ = 2πθ/λ, θ = scattering angle, λ = wavelength). Instruments which have been developed along these lines are described, especially the 40 m instrument in Jülich and the 80 m instrument at the high-flux reactor in Grenoble. The Grenoble instrument covers a range of scattering vectors between 1 Å−1 and 3.10−4Å−1; the maximum possible resolution is about 10−4 Å−1. Typical applications are reviewed and discussed, namely those dealing with (i) density and compositional fluctuations in solids (alloys, defect clusters, dislocations, grains), (ii) magnetic inhomogeneities in solids (alloys, magnetic domains), (iii) flux-line lattices in type-II superconductors (form factors, imperfections and morphology), (iv) polymers in the solid state, and (v) biological substances.
Nano-porous electrode systems by colloidal lithography for sensitive electrochemical detection: fabrication technology and properties (2008)

A porous metal-insulator-metal sensor system was developed with the ultimate goal of enhancing the sensitivity of electrochemical sensors by taking advantage of redox cycling of electro active molecules between closely spaced electrodes. The novel fabrication technology is based on thin film deposition in combination with colloidal self-assembly and reactive ion etching to create micro- or nanopores. This cost effective approach is advantageous compared to common interdigitated electrode arrays (IDA) since it does not require high definition lithography technology. Spin-coating and random particle deposition, combined with a new sublimation process are discussed as competing strategies to generate monolayers of colloidal spheres. Metal-insulator-metal layer systems with low leakage currents < 10 pA and an insulator thickness as low as 100 nm were obtained at high yield (typically > 90%). We also discuss possible causes of sensor failure with respect to critical fabrication processes. Short circuits which could occur during or as a result of the pore etching process were investigated in detail. Infrared microscopy in combination with focused ion beam etching/SEM were used to reveal a defect mechanism creating interconnects and increased leakage current between the top and bottom electrodes. Redox cycling provides for amplification factors of >100. A general applicability for electrochemical diagnostic assays is therefore anticipated.
Nucleotide Sequences of Membrane-Bound Hydrogenase Gene in Alcaligenes hydrogenophilus. (1992)

The nucleotide sequences of membrane-bound hydrogenase small (hupS) and large (hupL) subunit genes of hydrogen bacterium Alcaligenes hydrogenophilus were determined. The hupS and hupL genes encoded polypeptides of 363 and 619 amino acids, respectively. The hupS was located upstream of hupL with 35bp of intergenic region. The consensus ribosome-binding sequences were identified upstream of the start codons of hupS and hupL. Amino acid sequence of hupS is very similar to that of Rhodobacter capsulatus, Bradyrhizobium japonicum, and Azotobacter vinelandii at amino acid levels of 82%, 77%, and 81%, respectively. Similarly, amino acid sequence of HupL is similar to that of R. capsulatus, B. japonicum, and A. vinelandii at amino acid levels of 63%, 65%, and 68%, respectively. Northern hybridization analysis showed that hupS and hupL were co-transcribed, and addition of fructose to the culture medium remarkably decreased the amount of mRNA transcribed from hupS and hupL.
Identifying the Interaction between Genes and Gene Products Based on Frequently Seen Verbs in Medline Abstracts. (1998)

We have selected the most frequently seen verbs from raw texts made up of 1-million-words of Medline abstracts, and we were able to identify (or bracket) noun phrases contained in the corpus, with a precision rate of 90%. Then, based on the noun-phrase-bracketted corpus, we tried to find the subject and object terms for some frequently seen verbs in the domain. The precision rate of finding the right subject and object for each verb was about 73%. This task was only made possible because we were able to linguistically analyze (or parse) a large quantity of a raw corpus. Our approach will be useful for classifying genes and gene products and for identifying the interaction between them. It is the first step of our effort in building a genome-related thesaurus and hierarchies in a fully automatic way.
The Design of Online Communities Devoted to Health and Better Living: Using Social Interaction Features to Foster Online Contributions (2017)

A real transformation is happening with the social Web in the extent to which consumers are now equipped to both inform and express themselves about products, services, and health-related issues in general—outside traditional communication channels. Drawing on literature from social psychology, consumer behavior, and human-computer interaction, this research examines the effect of interface elements on the contribution of members of a large Online Health Community (OHC). The aim is to demonstrate how functionalities supporting social interaction influence participant decision-making, both in forming their attitude towards contributions and also their intention to contribute to the site. This study uses a sample of 404 participants exposed to the passeportsante.net OHC, the second-most important French language site, in terms of traffic, dealing with health issues.
Functional Interactions of Kluyveromyces lactis Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA (2022)

The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compensating for sequence loss due to incomplete DNA replication and nuclease action. Although telomerase RNA is highly divergent in sequence and length across fungi and mammals, structural motifs essential for telomerase function are conserved. Here, we show that Est2 from the budding yeast <i>Kluyveromyces lactis</i> (<i>kl</i>Est2) binds specifically to an essential three-way junction (TWJ) structure in <i>K. lactis</i> TER, which shares a conserved structure and sequence features with the essential CR4-CR5 domain of vertebrate telomerase RNA. <i>kl</i>Est2 also binds specifically to the template domain, independently and mutually exclusive of its interaction with TWJ. Furthermore, we present the high-resolution structure of the <i>kl</i>Est2 telomerase RNA-binding domain (<i>kl</i>TRBD). Mutations introduced in vivo in <i>kl</i>TRBD based on the solved structure or in TWJ based on its predicted RNA structure caused severe telomere shortening. These results demonstrate the conservation and importance of these domains and the multiple protein-RNA interactions between Est2 and TER for telomerase function.
Preparation of β-Ga2O3 films on off-angled sapphire substrates and solar-blind ultraviolet photodetectors (2022)

Abstract β -Ga 2 O 3 films have been prepared on (0001) sapphire substrates with different off-axis angles toward <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mo>&lt;</mml:mo> <mml:mn>11</mml:mn> <mml:mover> <mml:mn>2</mml:mn> <mml:mo>ˉ</mml:mo> </mml:mover> <mml:mn>0</mml:mn> <mml:mo>&gt;</mml:mo> </mml:math> by sol – gel method and the solar-blind ultraviolet photodetectors (PDs) with metal-semiconductor-metal structure have been fabricated on these films. The effects of off-angled sapphire substrates on the surface morphology and crystal quality of β -Ga 2 O 3 films have been systematically investigated. All the results indicate that to some extent the larger off-angled sapphire substrate could lead to the smoother surface morphology and higher crystal quality of β -Ga 2 O 3 films. Reduction in the numbers of in-plane rotational domains for β -Ga 2 O 3 films on off-angled substrates may result in the above-mentioned improvement, which have been confirmed by x-ray diffraction ϕ -scan. β -Ga 2 O 3 film grown on ∼7° off-angled sapphire substrate has ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mn>400</mml:mn> </mml:math> ) preferred orientation with the single-domain growth mode. Besides, the performance of β -Ga 2 O 3 PDs fabricated on different off-angled substrates show the same trend with changing the off-axis angles. The β -Ga 2 O 3 PD fabricated on ∼7° off-angled sapphire substrate has excellent optical characteristics with large photocurrent to dark current ratio of 430.53 and high UV–visible rejection ratio of 1.42 × 10 3 . These results would be helpful for improving the crystal-quality of hetero-epitaxy β -Ga 2 O 3 films by using off-angled sapphire substrates and fabricating the cost-effective mass-producible solar-blind ultraviolet PDs by sol–gel method.
Voltage to pressure conversion: are you getting `phased' by the problem? (2004)

The process of calibration provides the user with the sensitivity data necessary to convert the voltage measured at the end of the hydrophone cable to an acoustic pressure. This paper addresses the precise nature of how this data is used. Most regulatory standards simply require the user to use the sensitivity figure at the acoustic working frequency of the source in conjunction with a known (or pre-specified) `flatness' criterion for the overall frequency response. This paper questions the validity of this approach, and looks at the differences that can be obtained when the voltage to pressure conversion is accomplished by means of a deconvolution process that utilises all of the frequency response curve (as opposed a single data point). Theoretical and experimental comparisons between single frequency and full waveform deconvolution are presented.