gebhart/patrepeval huggingface dataset:
Characterization of the promoter region of the rat hepatocyte‐growth‐factor/scatter‐factor gene (1993)

Hepatocyte growth factor/scatter factor (HGF/SF) is a potent mitogen for hepatocytes in primary culture. In response to liver damage, the levels of HGF/SF mRNA change in various tissues. In this study, we isolated a genomic DNA fragment containing the promoter region of the rat HGF/SF gene and analyzed transcription-initiation sites and their utilization in response to acute liver injury. Rat HGF/SF-mRNA synthesis starts from at least three sites in the liver, spleen and kidney. One of these sites is preferentially utilized in the liver and spleen in response to acute liver injury. In the 5' flanking region, several cytokine-related sequence elements that might be involved in the regulation of HGF/SF-gene expression are located near the transcription-initiation sites. The effects of cytokines related to these sequence elements on the production of HGF/SF mRNA were examined using a cell culture system. Transforming growth factor-beta 1 (TGF-beta 1) inhibits the production of HGF/SF mRNA by Shay granulocytic sarcoma-derived cells. The TGF-beta 1-inhibitory element, one of the sequence elements present in the promoter sequence, may mediate the inhibition of HGF/SF-gene expression by TGF-beta 1.
Nitrogen-Doped Carbon Nanotube/Polymer Nanocomposites Towards Thermoelectric Applications (2016)

This study investigates the impact of nitrogen doping on the performance of carbon nanotube (CNT)/polymer nanocomposites for thermoelectric applications; this was performed through measurement of conductivity of the generated nanocomposites. Three different catalysts (Co, Fe, and Ni) were used to synthesize nitrogen-doped CNTs (N-CNTs) by chemical vapor deposition technique. Synthesized N-CNTs were melt-mixed with a polyvinylidene fluoride (PVDF) matrix with a small-scale mixer at a broad range of loadings from 0.3 to 3.5 wt.% and then compression molded. Measurement of electrical conductivity of the generated nanocomposites showed superior properties in the following order of the synthesis catalyst: Co &gt; Fe &gt; Ni. We employed various characterization techniques to figure out the reasons behind dissimilar electrical conductivity of the generated nanocomposites, i.e., transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, thermogravimetric analysis, light microscopy, and rheometry. It was found out, that the superior electrical conductivity of (N-CNT)Co nanocomposites was due to a combination of high synthesis yield, high aspect ratio, low nitrogen content, and high crystallinity of N-CNTs coupled with a good state of N-CNT dispersion. Moreover, it was revealed, that nitrogen doping had an adverse impact on electrical conductivity and, thus, on thermoelectric performance of CNT/polymer nanocomposites.
Hybrid Cryptographic Protocol for Secure Vehicle Data Sharing Over a Consortium Blockchain (2018)

The blockchain technology has recently attracted increasing interests in a wide range of use-cases. Among those, the management of vehicles' data and life cycle over a blockchain has sparked various research initiatives on a global scale, with the promise to prevent automobile frauds and to enable more collaborations between the involved stakeholders. In this paper, we investigate the problem of securing and sharing vehicles' data over a consortium blockchain, and we describe the architecture of the implemented proof-of-concept. Then, we introduce a novel hybrid cryptographic protocol to secure the access to vehicles' data between the involved stakeholders. Finally, we discuss the lessons learned acquired from the preliminary trials and we highlight the future research challenges and opportunities.
Design methodologies for silicon photonic integrated circuits (2014)

This paper describes design methodologies developed for silicon photonics integrated circuits. The approach presented is inspired by methods employed in the Electronics Design Automation (EDA) community. This is complemented by well established photonic component design tools, compact model synthesis, and optical circuit modelling. A generic silicon photonics design kit, as described here, is available for download at http://www.siepic.ubc.ca/GSiP.
A method to classify emotional expressions of text and synthesize speech (2004)

Representing emotional expressions on text-to-speech synthesis has been a interesting subject. We aim to add emotional expressions to synthetic speech. This system recognizes emotion based on the words in a sentence and synthesizes emotional speech.
A Neuro-vector-symbolic Architecture for Solving Raven's Progressive Matrices (2022)

Neither deep neural networks nor symbolic AI alone has approached the kind of intelligence expressed in humans. This is mainly because neural networks are not able to decompose joint representations to obtain distinct objects (the so-called binding problem), while symbolic AI suffers from exhaustive rule searches, among other problems. These two problems are still pronounced in neuro-symbolic AI which aims to combine the best of the two paradigms. Here, we show that the two problems can be addressed with our proposed neuro-vector-symbolic architecture (NVSA) by exploiting its powerful operators on high-dimensional distributed representations that serve as a common language between neural networks and symbolic AI. The efficacy of NVSA is demonstrated by solving the Raven's progressive matrices datasets. Compared to state-of-the-art deep neural network and neuro-symbolic approaches, end-to-end training of NVSA achieves a new record of 87.7% average accuracy in RAVEN, and 88.1% in I-RAVEN datasets. Moreover, compared to the symbolic reasoning within the neuro-symbolic approaches, the probabilistic reasoning of NVSA with less expensive operations on the distributed representations is two orders of magnitude faster. Our code is available at https://github.com/IBM/neuro-vector-symbolic-architectures.
Alveolar Neutrophil Functions and Cytokine Levels in Patients With the Adult Respiratory Distress Syndrome During Nitric Oxide Inhalation (1996)

It was recently demonstrated that nitric oxide (NO) inhalation improves arterial oxygenation in patients with the adult respiratory distress syndrome (ARDS). However, the potential adverse reaction of NO on inflammatory cells and mediators in the lung has not yet been investigated. In this study, we evaluated the impact of NO inhalation on lung polymorphonuclear neutrophil (PMN) activation and proinflammatory cytokine release, both of which are involved in the pathophysiology of ARDS. Two groups of patients with ARDS of similar etiologies were compared; one received NO (n=9) and the other did not (n=5). After 4 d of NO inhalation (18 ppm), PMN form bronchoalveolar lavage (BAL) showed a reduction in both spontaneous H2O2 production (p<0.05) and beta 2 integrin CD11b/CD18 expression (p<0.05). Moreover, the high levels of IL8 and IL-6 decreased in BAL fluid supernatants after NO inhalation (p<0.05). In the NO-untreated group of patients with ARDS, neither PMN activation nor levels of IL-8 and IL-6 in BAL fluid changed significantly on Day 4. These results suggest that NO inhalation might reduce lung inflammation in ARDS, as reflected by PMN activation status and IL-8/IL-6 release.
A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen (2011)

The methods proposed will demonstrate outcome-based evaluation of control of hyperglycemia in hospitalized veterans. By institutionalizing a process of statistically sound and efficient learning, and by integrating that learning with automatic implementation of best practice, the participating VA Healthcare Systems will accelerate improvements in the effectiveness of care.
Successful Control of Fracture Height Growth by Placement of Artificial Barrier (1995)

Abstract This paper presents a method to control fracture height growth through the selective placement of artificial barriers above and below the pay zone. These barriers are created prior to the actual treatment by pumping a mix of different size and density proppants with low viscosity carrying fluid, that allows fast settling of these proppants or, if desired, floatation to the top of the fracture channel or both. Typically a viscous pad is pumped to create a fracture channel. This pad is followed with 5–10 cp fluid slurry carrying a mix of heavier proppant that settles to the bottom of the fracture channel and a light proppant that rises to the top of the fracture channel. The proppant slurry is allowed to bridge at the top or the bottom tip of the fracture, inhibiting further growth of these tips. The actual treatment following this barrier placement is thus focused through these barriers confining itself within the barriers and resulting in a longer extension within the pay zone. Such controlled fracture height allows further optimization of fracture length by reducing or increasing the amount of proppant as called for in the design. Two case studies are presented in this paper from two formations known to suffer from fracture height growth.
Decay time in a cavity in slow or negative light regime (2013)

We investigate the decay time of a cavity containing strong dispersion achieved through electromagnetically induced transparency (EIT) in 4He*. We show that this concept is no longer relevant in the case of strong negative dispersion.
Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma (2021)

Budding Uninhibited By Benzimidazoles are a group of genes encoding proteins that play central roles in spindle checkpoint during mitosis. Improper mitosis may lead to aneuploidy which is found in many types of tumors. As a key mediator in mitosis, the dysregulated expression of BUBs has been proven to be highly associated with various malignancies, such as leukemia, gastric cancer, breast cancer, and liver cancer. However, bioinformatic analysis has not been applied to explore the role of the BUBs in sarcomas. Herein, we investigate the transcriptional and survival data of BUBs in patients with sarcomas using Oncomine, Gene Expression Profiling Interactive Analysis, Cancer Cell Line Encyclopedia, Kaplan-Meier Plotter, LinkedOmics, and the Database for Annotation, Visualization and Integrated Discovery. We found that the expression levels of BUB1, BUB1B and BUB3 were higher in sarcoma samples and cell lines than in normal controls. Survival analysis revealed that the higher expression levels of BUB1, BUB1B and BUB3 were associated with lower overall and disease-free survival in patients with sarcomas. This study implies that BUB1, BUB1B and BUB3 are potential treatment targets for patients with sarcomas and are new biomarkers for the prognosis of sarcomas.
Physical performance testing in mucopolysaccharidosis I: a pilot study (2004)

Individuals with MPS I have difficulty with arm and leg function and reduced endurance. The MPS-PPM is a clinically feasible measure that detects limitations in physical performance and may have potential to quantify changes in function following intervention.
Electric utility industry experience with geomagnetic disturbances (1991)

A geomagnetic disturbance (GMD) by its nature occurs globally and almost simultaneously. Severe geomagnetic storms cause problems for electric power systems. The vulnerability of electric power systems to such events has apparently increased during the last 10 to 20 years because power system transmission lines have become more interconnected and have increased in length and because power systems are now operated closer to their limits than in the past. In this report, the experience of electric utilities during geomagnetic storms is examined and analyzed. Measured data, effects on power system components, and power system impacts are considered. It has been found that electric power systems are susceptible to geomagnetically induced earth-surface potential gradients as small as few (2 to 3) volts per kilometer, corresponding to a storm of K-6 intensity over an area of high earth resistivity. The causes and effects are reasonably well understood, but additional research is needed to develop a better understanding of solar-induced geomagnetic storms and the responses of power systems to these types of storms. A better understanding of geomagnetic storms and the power systems' responses to GMDs is needed so that mitigation measures can be implemented that will make power systems less susceptible to severe geomagnetic disturbances. A GMD caused by a large high-altitude nuclear detonation is similar in many ways to that of solar-induced geomagnetic storms except that a nuclear-caused disturbance would be much more intense with a far shorter duration. 49 refs.
Endoscopic therapeutic esophageal interventions: what is new? What needs further study? What can we forget? (2005)

In 2004, new data on available esophageal therapeutic techniques became available. In addition, new information on an old established technique (brachytherapy for malignant dysphagia) and a new device (Gatekeeper system for the prevention of reflux) were presented.
Multivariable feedback design for regulating vapor compression cycles (2005)

This paper presents multivariable feedback control design for regulating a vapor compression cycle based on a lumped-parameter model. In particular, the conventional control strategy of SISO systems is studied based on the model and experimental tests, and compared to multivariable feedback control. It is shown that multivariable control of compressor speed and expansion valve opening has better performance than the existing SISO control method in regulating superheat and evaporating pressure. More importantly, with variable-speed compressor, electronic expansion, indoor and outdoor fans, evaporating and condensing pressures, the refrigerant superheat as well as subcool values can be simultaneously controlled to have the desired values such that desired COP can be maintained under different ambient conditions. It is expected that active multivariable feedback control will have wide applications in HVAC&R systems including air conditioners, heat pumps, and refrigerators etc. to achieve high performance and high energy-efficiency.
Effects of near-infrared heating and high frequency induction roller heating in continuous tape layup molding of CFRTP (2016)

Automated thermoplastic tape laying (ATL) and automated fiber placement (AFP) are high-potential manufacturing methods for continuous carbon fiber reinforced thermoplastic (CFRTP) composites which can ensure operational safety even in highly loaded components such as aircraft wing skins and fuselages or construction large scaled structures. This study aimed to reveal the heating behavior of CFRTP in continuous tape layup molding. The material used for the experiment was unidirectional carbon fiber reinforced polyamide 6 (CF/PA6) prepreg tape. The effects of processing conditions such as output of infrared heater, feed speed of prepreg tapes and heating temperature of pressure rollers on the tape laying behavior of prepreg tape were investigated. In the case of only near infrared heating, it was revealed that the difference in temperature between the upside and downside prepreg tape was increased significantly. Then, the joining strength was decreased significantly compared with using the infrared heater, because the moisture in the prepreg tapes was not removed completely. On the other hand, when the near infrared heater and heating roller were used, the difference in temperature between the upside and downside prepreg tape was decreased considerably. It was also revealed that the surface temperature of CF/PA6 prepreg tape and singe lap tensile strength tends to increase with decreasing the feed speed of prepreg tapes.
p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma (2011)

These data show evidence that p19(ARF) /p14(ARF) determines the pro- or anti-oncogenic activity of U-Stat3 and pY-Stat3 in Ras-dependent HCC progression.
Is Low Vitamin D Status A Risk Factor For Food Allergy? Current Evidence And Future Directions (2015)

Studies from several countries have reported an association between latitudes further from the equator and proxy markers of food allergy prevalence. As latitudes further from the equator are associated with lower sun exposure and vitamin D status (VDS), it has been proposed that low VDS may be a risk factor for food allergy. A range of basic science evidence supports the biological plausibility of this hypothesis; and recent work has identified a cross sectional association between low VDS and challenge proven food allergy in infants. Overall, however, the evidence regarding the relationship between VDS and food allergy remains controversial and the limited longitudinal data are discouraging. In this review we consider the evidence for and against low VDS as a risk factor for food allergy and discuss the possibility that other factors (including genetic variables) may contribute to the inconsistent nature of the available observational evidence. We then discuss whether genetic and/or environmental factors may modify the potential influence of VDS on food allergy risk. Finally, we argue that given the rising burden of food allergy, the balance of available evidence regarding the potential relevance of VDS to this phenomenon, and the inherent limitations of the existing observational data, there is a compelling case for conducting randomised clinical trials of vitamin D supplementation for the prevention of food allergy during early life.
The Role of Behavioral Ecotoxicology in Environmental Protection (2021)

For decades, we have known that chemicals affect human and wildlife behavior. Moreover, due to recent technological and computational advances, scientists are now increasingly aware that a wide variety of contaminants and other environmental stressors adversely affect organismal behavior and subsequent ecological outcomes in terrestrial and aquatic ecosystems. There is also a groundswell of concern that regulatory ecotoxicology does not adequately consider behavior, primarily due to a lack of standardized toxicity methods. This has, in turn, led to the exclusion of many behavioral ecotoxicology studies from chemical risk assessments. To improve understanding of the challenges and opportunities for behavioral ecotoxicology within regulatory toxicology/risk assessment, a unique workshop with international representatives from the fields of behavioral ecology, ecotoxicology, regulatory (eco)toxicology, neurotoxicology, test standardization, and risk assessment resulted in the formation of consensus perspectives and recommendations, which promise to serve as a roadmap to advance interfaces among the basic and translational sciences, and regulatory practices.
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin (2023)

&lt;p&gt;Supplementary methods and figures&lt;/p&gt;
Abstract 4777: Human suppressor of cytokine signaling 1 controls immunostimulatory activity of monocyte-derived dendritic cells (2010)

Abstract Dendritic cell (DC)-based tumor vaccines have only achieved limited clinical efficacy, underscoring the limitation of stimulatory strategies to elicit effective cytotoxic T lymphocyte (CTL) responses against self-tumor-associated antigens. Here, we investigate the role of human suppressor of cytokine signaling 1 (SOCS1), a feedback inhibitor of the Janus-activated kinase/signal transducer and activator of transcription signaling pathway, in regulating antigen presentation by human DCs (hDC). We find that human SOCS1 (hSOCS1)-silenced DCs have an enhanced stimulatory ability to prime self-antigen-specific CTLs in vitro and in a severe combined immunodeficient-hu mouse model. Human CTLs activated by SOCS1-silenced DCs, but not wild-type DCs, have an active lytic activity to natural antigen-expressing tumor cells. We further find that the capacity of hDCs to prime CTLs is likely controlled by SOCS1-restricted production and signaling of proinflammatory cytokines, such as interleukin-12. These results indicate a critical role of hSOCS1 in negatively regulating the immunostimulatory capacity of DCs and imply a translational potential of this alternative SOCS1 silencing strategy to develop effective DC vaccines. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4777.
[Left cor triatriatum. Clinical and echocardiographic polymorphism]. (1992)

Four cases of cor triatriatum in children aged from 4 days to 12 months are described. In one case isolated classical form of the disease occurred, and in the other it was associated respectively to ventricular septal defect, anomalous pulmonary venous connexion and persistence of left superior venae cava. One child had successful surgical correction, two died before surgery could be attempted and one waits operation. Relevant clinical and investigational data are described and the role of echocardiography as an excellent diagnostic tool is stressed. We conclude that isolated form of cor triatriatum can simulate primary lung disease and when associated to other cardiac anomalies it has an earlier diagnosis due to early referral. Surgical results and prognosis depend not only on associated anomalies but also on early diagnosis.
Thermal Decomposition Pathways of 1,3,3-Trinitroazetidine (TNAZ), Related 3,3-Dinitroazetidium Salts, and 15N, 13C, and 2H Isotopomers (1997)

The thermal decomposition of 1,3,3-trinitroazetidine (TNAZ) and related 3,3-dinitroazetidium (DNAZ+) salts was examined neat and in solution. TNAZ kinetics were found (160−250 °C) to be first-order and nearly identical neat and in benzene, with an activation energy of 46.6 kcal/mol (195 kJ/mol). The DNAZ+ salts were less thermally stable than TNAZ, and neat did not decompose in a first-order fashion. However, in aqueous solution the DNAZ+ salts did decompose following first-order kinetics; their rates were similar with minor differences apparently related to the strength of the anion as a conjugate base. Like simple nitramines such as dimethylnitramine, TNAZ tended to form N2O rather than N2, but unlike other nitramines it formed about as much NO as N2O. TNAZ isotopomers labeled with 13C and with 15N were prepared and used to identify the origin of the decomposition gases and the identity of the condensed-phase products. Early in the decomposition of TNAZ, most of the NO came from the nitro group attached to the azetidium ring nitrogen. Most of the N2O was the result of the nitro groups interacting with each other, while the majority of the N2 contained one nitrogen from the ring. Many condensed products have been identified, but five stand out because they are formed in the thermolysis of TNAZ and the three DNAZ+ salts [NO3-, Cl-, N(NO2)2-]. These are 3,5-dinitropyridine (M, always a minor product), 1-formyl-3,3-dinitroazetidine (L), 1,3-dinitroazetidine (K), 1-nitroso-3,3-dinitroazetidine (E), and 1-nitroso-3-nitroazetidine (G); the identity of the first four has been confirmed by use of authentic samples. Of these five, the last four have been shown to interconvert with TNAZ and each other under the conditions of these experiments. This study confirms the presence of two competitive TNAZ decomposition pathways. Under the conditions of this study, N−NO2 homolysis is slightly favored, but products, such as K, resulting from C−NO2 scission, are also well represented.