gebhart/patrepeval huggingface dataset:
Effect of dietary Moringa oleifera leaves on the performance, ileal microbiota and antioxidative status of broiler chickens (2019)

In this study, we investigated the effect of Moringa oleifera leaves (MOL) supplements on the performance, ileal microbiota carcass traits and biochemical and antioxidant parameters of broiler chickens. MOL was added to starter, grower and finisher diets at four levels (0%, 0.5%, 1.0% and 5.0%). A total of 320 one-day-old mixed-sex Cobb-500 broiler chicks were divided equally into four treatment groups, with 5 replicates of 16 chicks each until 42 days of age. Compared to the control group, chicks fed 0.5% and 1% MOL exhibited a higher final body weight (FBW), greater weight gain (BWG), and better average daily gain (ADG). Feed intake (FI) gradually decreased as the inclusion rate of MOL in the broilers' diet increased to 5%. The best feed conversion ratio (FCR), protein efficiency ratio (PER) and performance index (PI) were observed in broilers that were fed the MOL diet. The percentage of abdominal fat in broilers decreased significantly in response to dietary supplementation with MOL. The haematological profile in the MOL group revealed a lower WBC count and lymphocyte percentage but higher heterophil and H/L ratio without affecting haemoglobin and RBC count. The inclusion of MOL increased total serum protein, Ca and P levels but decreased glucose, cholesterol, triglycerides, AST and ALT concentrations. Moreover, dietary MOL increased the activities of GSH, CAT and SOD, GPx and GST while decreasing the TBARS level. The pH value decreased in the ileum of broilers fed the 1% and 5% MOL diet compared to the other treatments. Decreased ileal counts of E. coli, Salmonella and Staphylococcus spp. were observed whereas the total ileal Lactobacillus spp. count increased in broilers fed the MOL diet. In conclusion, the MOL supplement can enhance growth performance and antioxidant status, alter ileal microbiota and protect against enteropathogens with no deleterious effects on the broiler chickens.
Skin flap vaginal augmentation helps prevent and cure post obstetric fistula repair urine leakage: a critical anatomical analysis (2017)

Singapore skin flap restores elasticity and prevents and treats incontinence in patients with successful obstetric fistula repair.
Erythropoietin causes down regulation of colony-stimulating factor (CSF-1) receptors on peritoneal exudate macrophages of the mouse. (1983)

We have shown that erythropoietin (epo), the primary regulator of erythrocyte formation, diminished the binding to peritoneal exudate macrophages (PEM) of the principal macrophage growth regulator, colony-stimulating factor (CSF-1). The effect of epo on 125I-CSF-1 binding was dose-dependent; at a concentration of 1-2 U of epo/ml (10(-10) M), CSF-1 binding was almost completely suppressed. Erythropoietin did not compete with CSF-1 for occupancy of the latter's receptors. The effect of epo on CSF-1 binding occurred at 37 degrees C but not at 2 degrees C, and during the continuous exposure of PEM to epo at 37 degrees C we found that CSF-1 binding reached a nadir at 1 h and recovered to pre-exposure levels in 7 h. Our novel results are consistent with the notion that specific receptors for epo exist on the cell surface of PEM and that binding of epo sets in motion a series of cellular events resulting in the internalization of CSF-1 receptors. Thus epo causes down regulation of CSF-1 receptors on PEM. We have previously shown that epo causes suppression of CSF-induced granulocyte-macrophage colony formation by mouse bone marrow cells. The results we present here provide a possible mechanism for these results.
The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases (2000)

Long-term potentiation (LTP) in perforant path-granule cell synapses is decreased in aged rats, stressed rats, and rats injected intracerebroventricularly with the proinflammatory cytokine interleukin-1beta (IL-1beta). One factor that is common to these experimental conditions is an increase in the concentration of IL-1beta in the dentate gyrus, suggesting a causal relationship between the compromise in LTP and increased IL-1beta concentration. In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. These changes were paralleled by increased activity of the stress-activated kinases, c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase. Intracerebroventricular injection of IL-1beta increased reactive oxygen species production in hippocampal tissue, whereas IL-1beta and H(2)O(2) increased activities of both JNK and p38 in vitro. Dietary manipulation with antioxidant vitamins E and C blocked the increase in reactive oxygen species production, the stimulation of JNK and p38 activity, the attenuation of glutamate release, and the IL-1beta-induced inhibitory of LTP. We propose that IL-1beta stimulates activity of stress-activated kinases, which in turn may inhibit glutamate release and result in compromised LTP and that these actions are a consequence of increased production of reactive oxygen species.
Reaction of alien chromosome substitution and addition lines of hard red spring wheat to common root rot and black point (1993)

Resistance to common root rot and black point, caused by Cochliobolus sativus, was evaluated in alien chromosome substitution and addition lines of the cultivars 'Cadet' and 'Rescue'. Substitution of chromosome 5B in 'Rescue' with 5Ag from Agropyron elongatum decreased root rot susceptibility to a level intermediate between that in the susceptible 'Rescue' and the resistant 'Cadet'. The substitution of 'Rescue' chromosome 5A or 5D with 5Ag, or the addition of 5Ag to 'Rescue' complement had no consistent effect on root rot susceptibility. The root rot resistance of 'Cadet' was unaffected by substitution of chromosomes 5A, 5B, or 5D with 5Ag, or the addition of 5Ag. This indicates that the susceptible allele of the gene Crr is the primary determinant in the reaction of wheat to common root rot. Black point resistance in the susceptible cultivar 'Rescue' was significantly increased by substitution of chromosome 5B with 5Ag, or the addition of 5Ag. No corresponding effect was demonstrated for black point incidence in the moderately resistant cultivar 'Cadet' with substitution of chromosome 5Ag for 5B, or the addition of 5Ag. Chromosome 5Ag apparently carries one or more genes conferring resistance to black point. The identity of these lines was confirmed by restriction fragment length polymorphism analysis using group 5 chromosome arm specific probes. This extends the use of these molecular probes to the Agropyron genome.
Safe Control of Manufacturing Vehicles Research Towards Standard Test Methods | NIST (2012)

The National Institute of Standards and Technology‟s Intelligent Systems Division has been researching several areas leading to safe control of manufacturing vehicles to improve automated guided vehicle (AGV) safety standards. The research areas include:  AGV safety and control based on advanced two-dimensional (2D) sensors that detect moving standard test pieces representing humans;  Ability of advanced 3D imaging sensors, when mounted to an AGV or forklift, to detect stationary or moving objects and test pieces on the ground or hanging over the work area; and  Manned forklift safety based on advanced 3D imaging sensors that detect visible and non-visible regions for forklift operators. Experiments and results in the above areas are presented in this paper. The experimental results will be used to develop and recommend standard test methods, some of which are proposed in this paper, and to improve the standard stopping distance exception language and operator blind spot language in AGV standards.
Abstract A72: Prostate cancer incidence and mortality in Barbados, West Indies: Findings from the Barbados National Cancer Study (2009)

Purpose: To describe the incidence of prostate cancer and subsequent mortality in the predominantly African-origin population of Barbados,West Indies. This population shares a common heredity with African Americans (with lower admixture), and experiences similarly high rates of lifestylerelated noncommunicable disease. Methods: We identified all new cases of histologically confirmed prostate cancer occurring in Barbados between July 01, 2002 and December 31, 2007. We used death certification records to ascertain mortality for a 10-year period commencing January 1995. We identified prostate cancer as the underlying cause of death using nosology algorithms, and classified this cause as definite (a single listed cause, or death directly attributable to prostate cancer, including metastatic disease), or probable (multiple causes of death cited; death likely attributable to prostate cancer). Results: During the study period, 923 cases of prostate cancer were diagnosed for a rate of 158.9 (95% Confidence Interval: 148.7 – 169.6) per 100,000 standardized to the U.S. population. Comparable rates reported in the USA SEER (2000 – 2005) were 251.9 (95% CI: 249.2 – 254.6) and 158.6 (95% CI: 158.0 – 159.3) per 100,000 in African-American and White men, respectively. Age specific rates in Barbados increased from 5.3 (95% CI: 1.1 – 15.5) per 100,000 among those aged 40 to 44 to a peak at 988.7 (95% CI: 852.8 – 1140.2) per 100,000 at 70 to 74 years, declining thereafter. For the period 2002 – 2005, annual age-adjusted incidence was between 1.3 and 1.9 times higher in African American men (p Discussion: Prostate cancer incidence was lower in Barbadian than African American men, and was more comparable with rates in white American men. This may be partly due to a lower prevalence of PSA screening in Barbados with clinically more significant disease at presentation. In contrast, mortality rates in Barbadians were similar to those of African- mericans, highlighting the need for clinical and public health interventions to reduce the disproportionate disease burden.
Power efficient MPEG-4 decoder architecture featuring low-complexity error resilience (2003)

A media processor supporting MPEG-4 SP@LI and H.263 baseline has been developed. This processor includes a RISC core, dedicated video decoding hardware, audio/voice decoder, post processor, and some peripherals. In order to increase flexibility and reduce power dissipation, separated bus architecture, which may minimize the bus transaction, is adopted. An enhanced error resiliency is also equipped for error-prone environment, and additional innovative low-power design techniques are applied for portable applications. This processor was integrated in a 0.25/spl mu/m CMOS PLM process and contains 900K gates on 45mm/sup 2/ die with 50mW power dissipation at 27MHz.
Coadministration of glycogen-synthase kinase 3 inhibitor with morphine attenuates chronic morphine-induced analgesic tolerance and withdrawal syndrome (2013)

The results demonstrate the importance of GSK3 in reducing chronic morphine-induced tolerance and withdrawal syndrome. Although GSK3 is involved in diverse physiological functions, aiming at GSK3-related pathway could still be a potential tool to improve therapeutic quality in clinical morphine treatment.
Distributed Boundary Estimation using Sensor Networks (2006)

We examine the problem of determining boundaries occurring in natural phenomena using sensor networks. Sensor nodes remotely collect data about various points on the boundary. From this data, we estimate the boundary along with the confidence intervals using a regression relationship among sensor locations and the distances to the boundary. The confidence intervals are guaranteed to be narrower than a specified maximum width. Our distributed boundary estimation strategy uses a hierarchical structure of clusters of sensor nodes and requires 20-50% less messages as compared to a centralized scheme. The computed intervals show desired coverage of the true boundary points. Further, motivated by the practical need to estimate the boundary with a minimum number of sensors, we develop an adaptive approach for turning sensors on and off. The number of ON sensors in this scheme is only about 15% more than what a practical Oracle needs, to evaluate the boundary and confidence intervals around it. Our algorithms are also evaluated using data from real sensors on a testbed
The Case for Practical Clinical Trials in Psychiatry (2005)

To implement the practical clinical trials model in psychiatry will require stable funding for network construction and maintenance plus methodological innovation in governance and trial selection, assessment, treatment, data management, site management, and data analytic procedures.
CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects (2020)

Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopment as a part of the schizophrenia pathophysiology. However, it is unclear to what extent synapse elimination is present during various stages of the disease, which is of clinical importance as in a real-world setting most subjects received their first-episode psychosis (FEP) diagnosis not until their mid-twenties. In the present study, we measured cerebrospinal fluid (CSF) concentrations of the two pre-synaptic proteins synaptosomal-associated protein 25 (SNAP-25) and synaptotagmin-1 (SYT-1), both of which are increased in conditions of ongoing synaptic degeneration, in 44 FEP subjects (mean age 29.9 years) and 21 healthy controls (25.9 years) using immunoprecipitation mass spectrometry. Neither protein was found to differ between healthy controls and patients, and they showed no correlation with symptom ratings, cognitive performance or antipsychotic medication. Additional studies in high-risk subjects in the early prodromal phase will be needed to address if excessive synapse destruction occurs before the development of overt psychotic symptoms.
Prostaglandin F2α-F-Prostanoid Receptor Signaling Promotes Neutrophil Chemotaxis via Chemokine (C-X-C Motif) Ligand 1 in Endometrial Adenocarcinoma (2009)

The prostaglandin F(2alpha) (PGF(2alpha)) receptor (FP) is elevated in endometrial adenocarcinoma. This study found that PGF(2alpha) signaling via FP regulates expression of chemokine (C-X-C motif) ligand 1 (CXCL1) in endometrial adenocarcinoma cells. Expression of CXCL1 and its receptor, CXCR2, are elevated in cancer tissue compared with normal endometrium and localized to glandular epithelium, endothelium, and stroma. Treatment of Ishikawa cells stably transfected with the FP receptor (FPS cells) with 100 nmol/L PGF(2alpha) increased CXCL1 promoter activity, mRNA, and protein expression, and these effects were abolished by cotreatment of cells with FP antagonist or chemical inhibitors of Gq, epidermal growth factor receptor, and extracellular signal-regulated kinase. Similarly, CXCL1 was elevated in response to 100 nmol/L PGF(2alpha) in endometrial adenocarcinoma explant tissue. CXCL1 is a potent neutrophil chemoattractant. The expression of CXCR2 colocalized to neutrophils in endometrial adenocarcinoma and increased neutrophils were present in endometrial adenocarcinoma compared with normal endometrium. Conditioned media from PGF(2alpha)-treated FPS cells stimulated neutrophil chemotaxis, which could be abolished by CXCL1 protein immunoneutralization of the conditioned media or antagonism of CXCR2. Finally, xenograft tumors in nude mice arising from inoculation with FPS cells showed increased neutrophil infiltration compared with tumors arising from wild-type cells or following treatment of mice bearing FPS tumors with CXCL1-neutralizing antibody. In conclusion, our results show a novel PGF(2alpha)-FP pathway that may regulate the inflammatory microenvironment in endometrial adenocarcinoma via neutrophil chemotaxis.
Study of Intrapatient Variability and Reproducibility of Quantitative Tumor Perfusion Parameters Evaluated With Dynamic Contrast-Enhanced Ultrasonography (2017)

This study showed that area under the curve and area under the washout are the 2 most reproducible DCE-US parameters.
Cloning and Nucleotide Sequence of the KHS Killer Gene of Saccharomyces cerevisiae. (1991)

A 5.3-kbp fragment of the KHS gene was cloned from a genomic bank of Saccharomyces cerevisiae No. 115 constructed with an E. coli as the host and YEp13 as the vector. A non-killer yeast strain was transformed to a killer strain with the multi-copy vector containing the KHS gene, and the transformant could secrete 3-4 times more killer toxin into culture media than the donor, strain No. 115. The KHS toxin was purified 80-fold from the culture filtrate by gel filtration and column chromatography. The nucleotide sequence of a 2.8-kbp fragment of the KHS DNA that was enough for the expression of the killer activity was identified, and we found an open reading frame consisted of 2124 bp. Comparison of the open reading frame and N-terminal amino acid sequence of purified KHS toxin, suggested that the presumed peptide from the KHS gene might be processed between 36Gln and 37Ala before secretion.
Osteomyelitis Complicating Sacral Pressure Ulcers: Whether or Not to Treat With Antibiotic Therapy (2018)

The treatment of osteomyelitis in patients with stage IV sacral pressure ulcers is controversial. We conducted a systematic literature review and did not find evidence of benefit of antibacterial therapy in this setting without concomitant surgical debridement and wound coverage. Furthermore, many patients with chronically exposed bone do not have evidence of osteomyelitis when biopsied, and magnetic resonance imaging may not accurately distinguish osteomyelitis from bone remodeling. The goal of therapy should be local wound care and assessment for the potential of wound closure. If the wound can be closed and osteomyelitis is present on bone biopsy, appropriate antibiotic therapy is reasonable. We find no data to support antibiotic durations of >6 weeks in this setting, and some authors recommend 2 weeks of therapy if the osteomyelitis is limited to cortical bone. If the wound will not be closed, we find no clear evidence supporting a role for antibiotic therapy.
ChemInform Abstract: Development of a Suzuki Cross‐Coupling Reaction Between 2‐Azidoarylboronic Pinacolate Esters and Vinyl Triflates to Enable the Synthesis of [2,3]‐Fused Indole Heterocycles. (2014)

ChemInformVolume 45, Issue 36 Heterocyclic Compounds ChemInform Abstract: Development of a Suzuki Cross-Coupling Reaction Between 2-Azidoarylboronic Pinacolate Esters and Vinyl Triflates to Enable the Synthesis of [2,3]-Fused Indole Heterocycles. Navendu Jana, Navendu Jana Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this authorQuyen Nguyen, Quyen Nguyen Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this authorTom G. Driver, Tom G. Driver Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this author Navendu Jana, Navendu Jana Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this authorQuyen Nguyen, Quyen Nguyen Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this authorTom G. Driver, Tom G. Driver Dep. Chem., Univ. Ill., Chicago, IL 60607, USASearch for more papers by this author First published: 21 August 2014 https://doi.org/10.1002/chin.201436134Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume45, Issue36September 9, 2014 RelatedInformation
Red Ginseng Acidic Polysaccharide (RGAP) in Combination with IFN-γ Results in Enhanced Macrophage Function through Activation of the NF-κB Pathway (2008)

This study examined the effects of red ginseng acidic polysaccharide (RGAP) on macrophage-mediated cytotoxicity towards murine melanoma B16 cells. RGAP alone had no effect on killing of tumor cells. RGAP treatment increased the production of interleukin-1 (IL-1), IL-6, and nitric oxide (NO) by macrophages, whereas tumor necrosis factor (TNF-alpha) and reactive oxygen species (ROS) production were not changed by RGAP. However, treatment of macrophages with a combination of RGAP and recombinant interferon-gamma (rIFN-gamma) enhanced killing of tumor cells. In addition, the combination treatment showed marked cooperative induction of IL-1, IL-6, TNF-alpha, and NO production. Electrophoretic mobility shift assay analysis revealed that treatment of macrophages with RGAP plus rIFN-gamma induced the activation of the nuclear factor-kappa B (NF-kappaB) transcription factor. In agreement with this, the combination treatment resulted in increased NF-kappaB-p65 expression. The present results demonstrate synergistic effects on macrophage function of RGAP in combination with rIFN-gamma, and suggest that NF-kappaB plays an important role in mediating these effects. These data also support the development of clinical studies of this combination.
Purification and characterization of human platelet glutathione-S- transferase (1986)

A glutathione-S-transferase was isolated and purified to homogeneity from human platelets. With a combination of ammonium sulfate fractionation and chromatographic methods, 0.2 mg of pure enzyme was obtained from 9 X 10(11) platelets with a 12% recovery. The purified enzyme had a specific activity of 7.5 U per milligram, representing an approximately 1,100-fold purification. The enzyme was found to be anionic, with an isoelectric point of 4.6. With reduced glutathione as a co-substrate, platelet glutathione-S-transferase was most active with the synthetic substrate, 1-chloro-2,4-dinitrobenzene, less active with 1,2-dichloro-4-nitrobenzene, and essentially inactive with nitroglycerin and 1,2-epoxy-3-(p-nitrophenoxy)-propane. The pH optimum for activity with glutathione and 1-chloro-2,4-dinitrobenzene was 7.0. Indomethacin (1-(p-chlorobenzoyl)-5-methoxy-2-methyindole-3-acetic acid), a chlorobenzene derivative, noncompetitively inhibited human platelet glutathione-S-transferase with an apparent KI of 0.23 mmol/L. This study represents the first complete purification and characterization of a glutathione-S-transferase from platelets. The presence of this enzyme in the platelet, within which high concentrations of reduced glutathione coexist, suggests the potential importance of the platelet in detoxification reactions and in the synthesis of the glutathione adducts of leukotriene metabolism.