gebhart/patrepeval huggingface dataset:
A new understanding on the mechanism of fountain solution in the prevention of ink transfer to the non-image area in conventional offset lithography (2004)

In conventional offset lithographic printing, it has been well established that the existence of a continuous layer of fountain solution (FS) on the surface of the non-image area is an essential condition to ensure correct operation of lithography. However, the mechanistic function of FS in preventing the ink from being transferred onto the non-image area has not been fully understood. Several major mechanistic interpretations can be found in the literature, which are based either on comparing of static works of adhesion and cohesion of ink and FS, or on the splitting of the 'weaker' FS layer. Although the latter becomes more accepted, direct experimental evidence is difficult to find in the literature. On the other hand, confusing information found in the literature showed that the ink-transfer (or non-transfer) observations reported in many case studies correlate well with simple comparisons of works of adhesion, cohesion and spreading data of ink/FS, ink/plate and FS/plate obtained under the static condition. These results, therefore, imply that, in explaining the function of FS in preventing ink transfer to the non-image area, the ink/FS interfacial adhesion failure would be the dominant mechanism. The work presented in this study covered two specific areas in order to address and better understand the responses of ink and FS layers and their interface to forces encountered during ink transfer. Firstly, an analysis of lithographic plates contaminated with a cationic polymer revealed that the violation of the ink non-transfer condition of the plate non-image area due to contamination could be predicted by traditional criteria of plate wetting and works of adhesion and cohesion. However, these traditional criteria cannot reliably predict the non-transfer condition of the ink on the clean non-image area that was covered by FS. Secondly, in some novel experiments conducted in this study using ice or Teflon as a substrate, the works of adhesion and cohesion were not able to predict ink transfer in most cases. Direct experimental evidence from this work revealed that splitting of the FS layer was involved in the prevention of ink transfer to the non-image areas, and that the thickness of the FS layer was critical in allowing the splitting to occur.
Denijs Dille: Thematisches Verzeichnis der Jugendwerke Bela Bartoks 1890-1904 (1975)

des Budapester Bart6k-Archivs. Solange eine umfassende Bibliographie des ganzen Bart6k'schen Werkes nicht zustandekommt, bleibt diese Unternehmung ein Grundstein im fortwahrend wachsenden Gebaude der Bart6k-Forschung. Wie wichtig es war, in Bart6ks Jugendwerk endlich einmal sichere Orientierungspunkte zu bestimmen, kann durch das Beispiel der Dictionary of Twentieth-Century Composers von Kenneth Thompson illustriert werden (London, 1973): es gibt hier kaum eine einzige Angabe die Juvenilia Bart6ks betreffend, die im Lichte von Dilles Forschungen nicht richtiggestellt werden miiBte. Das Verzeichnis ist gleichsam die Kr6nung eines wissenschaftlichen Lebenswerkes, was auch den auferordentlich subjektiven Kontakt des Verfassers zum bearbeiteten Stoff erklirt. Der geborene Belgier Dille hatte bereits 1937 die pers6nliche Bekanntschaft Bart6ks gemacht und in seinem Buche Bela Bart6k in 1939 eines der ersten authentischen
A comparison of a short half‐life marker (low‐dose isoniazid), a long half‐life pharmacological indicator (low‐dose phenobarbitone) and measurements of a controlled release ‘therapeutic drug’ (metoprolol, Metoros) in reflecting incomplete compliance by volunteers. (1990)

1. Although, long half-life compounds appear to be more appropriate pharmacological indicators of compliance with treatment, short half-life markers or measurements of short half-life therapeutic drugs are frequently used. 2. We have compared the usefulness of low-dose phenobarbitone (a long half-life indicator), low dose isoniazid (a short half-life marker) and controlled release metoprolol (Metros) (a controlled release formulation of a short half-life 'therapeutic' drug) in seven volunteers with simulated partial (two thirds) compliance. 3. Detection of isoniazid metabolites in urine had an 83% sensitivity and 94% specificity for detecting ingestion within the previous 24 h and 100% sensitivity and 82% specificity for detecting ingestion within the past 6 h but gave no indication of the longer term pattern of compliance. 4. At 28 days (a time when steady-state would be obtained for all three drugs) phenobarbitone plasma levels were 70% (66-76%)--median and interquartile range--of the expected steady-state level if compliance had been complete. Corresponding figures for metoprolol were 82% (37-100%). 5. Measurement of phenobarbitone was much superior to isoniazid or metoprolol measurements in reflecting partial compliance over the previous 1 to 4 weeks.
Neuronal preconditioning with the antianginal drug, bepridil (2007)

It has recently been shown that the antianginal drug bepridil (BEP) activates mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels and thus confers cardioprotection. Our aim was to investigate whether BEP could induce preconditioning in cultured rat cortical neurons. Although BEP depolarized isolated and in situ mitochondria and increased reactive oxygen species generation, no acute protection was observed. However, a 3-day BEP-treatment elicited dose-dependent delayed neuroprotection against 180 min of oxygen-glucose deprivation (cell viability: untreated, 52.5 +/- 0.85%; BEP 1 micromol/L, 59.6 +/- 1.53%*; BEP 2.5 micromol/L, 71.9 +/- 1.23%*; BEP 5 micromol/L, 95.3 +/- 0.89%*; mean +/- SEM; *p < 0.05 vs. untreated) and 60 min of glutamate excitotoxicity (200 micromol/L; cell viability: untreated, 54.1 +/- 0.69%; BEP 1 micromol/L, 61.2 +/- 1.19%*; BEP 2.5 micromol/L, 78.1 +/- 1.67%*; BEP 5 micromol/L, 91.2 +/- 1.20%*; mean +/- SEM; *p < 0.05 vs. untreated), and inhibited the reactive oxygen species surge upon glutamate exposure. The protection was antagonized with co-application of the superoxide dismutase mimetic M40401, but not with reduced glutathione, catalase, or with the mitoK(ATP) blocker 5-hydroxydecanoate. Furthermore, BEP treatment resulted in increased levels of phosphorylated protein kinase C, manganese-dependent superoxide dismutase, glutathione peroxidase, and Bcl-2. Our results indicate that BEP induces delayed neuronal preconditioning which is dependent on superoxide generation but perhaps not on direct mitoK(ATP) activation.
The expanding clinical and genetic spectrum of ATP1A3-related disorders (2014)

AHC and RDP constitute clinical prototypes in a continuous phenotypic spectrum of ATP1A3-related disorders. Intermediate phenotypes combining criteria of both conditions are increasingly recognized. Efficient stepwise mutation analysis of the ATP1A3 gene may prioritize those exons where current state of knowledge indicates mutational clusters.
Peroxisomal and Mitochondrial Oxidation of Fatty Acids in the Heart, Assessed from the 13C Labeling of Malonyl-CoA and the Acetyl Moiety of Citrate (2004)

We previously showed that a fraction of the acetyls used to synthesize malonyl-CoA in rat heart derives from partial peroxisomal oxidation of very long and long-chain fatty acids. The 13C labeling ratio (malonyl-CoA)/(acetyl moiety of citrate) was >1.0 with 13C-fatty acids, which yields [13C]acetyl-CoA in both mitochondria and peroxisomes and < 1.0 with substrates, which yields [13C]acetyl-CoA only in mitochondria. In this study, we tested the influence of 13C-fatty acid concentration and chain length on the labeling of acetyl-CoA formed in mitochondria and/or peroxisomes. Hearts were perfused with increasing concentrations of labeled docosanoate, oleate, octanoate, hexanoate, butyrate, acetate, or dodecanedioate. In contrast to the liver, peroxisomal oxidation of 1-13C-fatty acids in heart does not form [1-13C]acetate. With [1-13C]docosanoate and [1,12-13C2]dodecanedioate, malonyl-CoA enrichment plateaued at 11 and 9%, respectively, with no detectable labeling of the acetyl moiety of citrate. Thus, in the intact rat heart, docosanoate and dodecanedioate appear to be oxidized only in peroxisomes. With [1-13C]oleate or [1-13C]octanoate, the labeling ratio >1 indicates the partial peroxisomal oxidation of oleate and octanoate. In contrast, with [3-13C]octanoate, [1-13C]hexanoate, [1-13C]butyrate, or [1,2-13C2]acetate, the labeling ratio was <0.7 at all concentrations. Therefore, in rat heart, (i) n-fatty acids shorter than 8 carbons do not undergo peroxisomal oxidation, (ii) octanoate undergoes only one cycle of peroxisomal beta-oxidation, (iii) there is no detectable transfer to the mitochondria of acetyl-CoA from the cytosol or the peroxisomes, and (iv) the capacity of C2-C18 fatty acids to generate mitochondrial acetyl-CoA decreases with chain length.
Translation by Structural Correspondences (2003)

We sketch and illustrate an approach to machine translation that exploits the potential of simultaneous correspondences between separate levels of linguistic representation, as formalized in the LFG notion of codescriptions.The approach is illustrated with examples from English, German and French where the source and the target language sentence show noteworthy differences in linguistic analysis.
Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels (2017)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Evaluation of a Multiple-Cycle, Recombinant Virus, Growth Competition Assay That Uses Flow Cytometry To Measure Replication Efficiency of Human Immunodeficiency Virus Type 1 in Cell Culture (2006)

Human immunodeficiency virus type 1 (HIV-1) replication efficiency or fitness, as measured in cell culture, has been postulated to correlate with clinical outcome of HIV infection, although this is still controversial. One limitation is the lack of high-throughput assays that can measure replication efficiency over multiple rounds of replication. We have developed a multiple-cycle growth competition assay to measure HIV-1 replication efficiency that uses flow cytometry to determine the relative proportions of test and reference viruses, each of which expresses a different reporter gene in place of nef. The reporter genes are expressed on the surface of infected cells and are detected by commercially available fluorescence-labeled antibodies. This method is less labor-intensive than those that require isolation and amplification of nucleic acids. The two reporter gene products are detected with similar specificity and sensitivity, and the proportion of infected cells in culture correlates with the amount of viral p24 antigen produced in the culture supernatant. HIV replication efficiencies of six different drug-resistant site-directed mutants were reproducibly quantified and were similar to those obtained with a growth competition assay in which the relative proportion of each variant was measured by sequence analysis, indicating that recombination between the pol and reporter genes was negligible. This assay also reproducibly quantified the relative fitness conferred by protease and reverse transcriptase sequences containing multiple drug resistance mutations, amplified from patient plasma. This flow cytometry-based growth competition assay offers advantages over current assays for HIV replication efficiency and should prove useful for the evaluation of patient samples in clinical trials.
Application of Random Forest in Predicting Fault-Prone Classes (2008)

There are available metrics for predicting fault prone classes, which may help software organizations for planning and performing testing activities. This may be possible due to proper allocation of resources on fault prone parts of the design and code of the software. Hence, importance and usefulness of such metrics is understandable, but empirical validation of these metrics is always a great challenge. Random forest (RF) algorithm has been successfully applied for solving regression and classification problems in many applications. This paper evaluates the capability of RF algorithm in predicting fault prone software classes using open source software. The results indicate that the prediction performance of random forest is good. However, similar types of studies are required to be carried out in order to establish the acceptability of the RF model.
Pharmacological activation changes stiffness of cultured human airway smooth muscle cells (1996)

Using magnetic twisting cytometry (MTC), we measured the cytoskeletal stiffness of adherent human airway smooth muscle (HASM) cells. We hypothesized that modulation of actin-myosin interactions by application of contractile agonists would induce changes in cytoskeletal stiffness. In cells plated on high-density collagen, bradykinin (10(-6) M) and histamine (10(-4) M) increased stiffness by 85 +/- 15 and 68 +/- 16%, respectively. Increases in cell stiffness were also consistently observed after acetylcholine, substance P, and KCl. The bronchodilator agonists isoproterenol, prostaglandin E2, forskolin, dibutryl adenosine 3', 5'-cyclic monophosphate, and 8-bromoguanosine 3', 5'-cyclic monophosphate each caused a dose-dependent decrease in cell stiffness in unstimulated as well as bradykinin-treated cells. HASM cells plated on high-density collagen were stiffer than cells plated on low-density collagen (126 +/- 16 vs. 43 +/- 3 dyn/cm2) and developed more pronounced increases in stiffness in response to bradykinin as well as more pronounced decreases in stiffness in response to isoproterenol. These results are consistent with the hypothesis that modulation of actin-myosin interactions by application of contractile agonists causes changes in cytoskeletal stiffness of HASM cells. MTC may be a valuable tool for evaluating the mechanisms of pharmacomechanical coupling in airway smooth muscle cells in culture.
Predictive design procedures, VESYS users manual : an interim design method for flexible pavements using the VESYS structural subsystem (1978)

This manual has been written to provide the pavement manager and design engineer with a ready reference of procedures to predict the structural responses and hence the integrity of flexible pavements. A pavement section of known geometry is chosen, and its behavior over time is predicted by sets of mechanistic models which have been computer programmed. The computer program package known as the VESYS System computes pavement response, distress, and serviceability. Results of the analysis must be compared with sets of decision criteria imposed by the user agency. The analysis process is repeated until the computed levels of pavement behavior over a specified lifetime, meet the established design criteria. The manual is developed so that it can be used with a minimal amount of reference to other materials, however, supporting references are provided throughout and these should be consulted for a better understanding of the methods and concepts presented. As new information and test procedures become available and refinements are made to the analyses procedures, updated references will be distributed to replace or be added to the current information.\n
Stratified synthesis: automatically learning the x86-64 instruction set (2016)

The x86-64 ISA sits at the bottom of the software stack of most desktop and server software. Because of its importance, many software analysis and verification tools depend, either explicitly or implicitly, on correct modeling of the semantics of x86-64 instructions. However, formal semantics for the x86-64 ISA are difficult to obtain and often written manually through great effort. We describe an automatically synthesized formal semantics of the input/output behavior for a large fraction of the x86-64 Haswell ISA’s many thousands of instruction variants. The key to our results is stratified synthesis, where we use a set of instructions whose semantics are known to synthesize the semantics of additional instructions whose semantics are unknown. As the set of formally described instructions increases, the synthesis vocabulary expands, making it possible to synthesize the semantics of increasingly complex instructions. Using this technique we automatically synthesized formal semantics for 1,795 instruction variants of the x86-64 Haswell ISA. We evaluate the learned semantics against manually written semantics (where available) and find that they are formally equivalent with the exception of 50 instructions, where the manually written semantics contain an error. We further find the learned formulas to be largely as precise as manually written ones and of similar size.
Nanogram Determination of Indium Using Epithermal Neutrons and Its Application in Potential Source Contribution Function of Airborne Particulate Matter in the Arctic Aerosol (1992)

To test the recent advances in receptor modeling for the identification of long-range transport of regional source signatures of airborne particulate matter, an epithermal irradiation facility to determine indium has been specifically constructed. Analysis of filter samples collected weekly over a 5-yr period has indicated that indium in the arctic atmosphere is strongly dependent on season. Typical detection limits were 0.1 ng per one-eighth of a 20.3-× 25.4-cm Whatman filter. The airborne concentrations of indium are extremely elevated in the winter and spring months, and they almost disappear in the summer months. The application of the potential source contribution function has indicated that the indium originates from several areas in Eurasia as well as from known “hot spots” in North America.
N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts (2000)

Alpha-phenyl-N-t-butyl nitrone (PBN), a spin trap, scavenges hydroxyl radicals, protects tissues from oxidative injury, and delays senescence of both normal human lung fibroblasts (IMR90) and senescence-accelerated mice. N-t-butyl hydroxylamine and benzaldehyde are the breakdown products of PBN. N-t-Butyl hydroxylamine delays senescence of IMR90 cells at concentrations as low as 10 microM compared with 200 microM PBN to produce a similar effect, suggesting that N-t-butyl hydroxylamine is the active form of PBN. N-Benzyl hydroxylamine and N-methyl hydroxylamine compounds unrelated to PBN were also effective in delaying senescence, suggesting the active functional group is the N-hydroxylamine. All the N-hydroxylamines tested significantly decreased the endogenous production of oxidants, as measured by the oxidation of 2', 7'-dichlorodihydrofluorescin and the increase in the GSH/GSSG ratio. The acceleration of senescence induced by hydrogen peroxide is reversed by the N-hydroxylamines. DNA damage, as determined by the level of apurinic/apyrimidinic sites, also decreased significantly following treatment with N-hydroxylamines. The N-hydroxylamines appear to be effective through mitochondria; they delay age-dependent changes in mitochondria as measured by accumulation of rhodamine-123, they prevent reduction of cytochrome C(FeIII) by superoxide radical, and they reverse an age-dependent decay of mitochondrial aconitase, suggesting they react with the superoxide radical.
Proteinase‐activated receptor‐2 mediates itch: a novel pathway for pruritus in human skin (2004)

Proteinase‐activated receptors are G‐protein‐coupled receptors with seven‐transmembrane domains activated by serine proteinases. PAR‐2 is a receptor for mast cell tryptase, house dust mite allergens, bacterial antigens and trypsin, for example, indicating a role of PAR‐2 during inflammation and immune responses. In the skin, PAR‐2 is expressed by keratinocytes, endothelial cells, certain immune cells and nerves, suggesting a broad regulatory role of proteases in the skin. Recently, PAR‐2 has been demonstrated to be involved in neurogenic inflammation. Therefore, we examined whether neuronal PAR‐2 may be involved in pruritus of human skin. The endogenous PAR‐2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR‐2 was markedly enhanced on primary afferent nerve fibres in skin biopsies of AD patients. Intracutaneous injection of endogenous PAR‐2 agonists provoked enhanced and prolonged itch when applied intralesionally. Interestingly, itch upon mast cell degranulation prevailed despite local antihistamines in AD patients only. Thus, we identified enhanced PAR‐2 signalling as a new link between inflammatory and sensory phenomena in AD patients. PAR‐2 antagonists, thus, represent a promising therapeutic target for the treatment of cutaneous neurogenic inflammation and pruritus.
Analysis of Peripapillary Atrophy in Relation to Macular Geographic Atrophy in Age-Related Macular Degeneration (2016)

Peripapillary atrophy is highly prevalent in eyes with GA due to AMD. Assessment of the buffer zone in eyes with nonconfluent PPA at baseline may be helpful to identify subjects at risk for the progression to confluent PPA. In future interventional clinical trials, it may be useful to exclude any eyes both with confluent PPA at baseline and at risk for development of confluent PPA over time to improve the accuracy of GA lesion size quantification and its enlargement over time.
Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical (2011)

These results indicate that progesterone, when administered immediately after nerve injury, and for a sufficient period of time, can prevent the development of neuropathic pain, and may offer new strategies for the treatment of this highly debilitating condition.
ChemInform Abstract: A Mild and Convenient “Dry” Hydrolysis of Amides to Carboxylic Acids. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hybrid CuTCNQ/AgTCNQ Metal‐Organic Charge Transfer Complexes via Galvanic Replacement vs Corrosion‐Recrystallization (2014)

This study reports a hybrid of two metal‐organic semiconductors that are based on organic charge transfer complexes of 7,7,8,8‐tetracyanoquinodimethane (TCNQ). It is shown that the spontaneous reaction between semiconducting microrods of CuTCNQ with Ag + ions leads to the formation of a CuTCNQ/AgTCNQ hybrid, both in aqueous solution and acetonitrile, albeit with completely different reaction mechanisms. In an aqueous environment, the reaction proceeds by a complex galvanic replacement (GR) mechanism, wherein in addition to AgTCNQ nanowires, Ag 0 nanoparticles and Cu(OH) 2 crystals decorate the surface of CuTCNQ microrods. Conversely, in acetonitrile, a GR mechanism is found to be thermodynamically unfavorable and instead a corrosion‐recrystallization mechanism leads to the decoration of CuTCNQ microrods with AgTCNQ nanoplates, resulting in a pure CuTCNQ/AgTCNQ hybrid metal‐organic charge transfer complex. While hybrids of two different inorganic semiconductors are regularly reported, this report pioneers the formation of a hybrid involving two metal‐organic semiconductors that will expand the scope of TCNQ‐based charge transfer complexes for improved catalysis, sensing, electronics, and biological applications.