gebhart/patrepeval huggingface dataset:
Modeling the Appearance of Special Effect Pigment Coatings (2001)

Metallic and pearlescent coatings are becoming increasingly important in automotive, currency, and cosmetic applications. These coatings consist of metallic or dielectric platelets suspended in a binder, and are often applied between a pigmented basecoat, and a transparent topcoat. The scattering properties of these composite coatings vary depending upon the incident and viewing directions, as well as the wavelength. The complex nature of the scattering arises from the competition between multiple scattering sources: front surface reflection from the topcoat, reflection from the platelets, diffuse scattering from the pigmented undercoat, and scattering between platelets. The complex interplay between multiple scattering sources affects the ability to achieve quality control during the preparation of these coatings. In addition, the topcoat surface morphology, the properties of the pigmented basecoat, and the intrinsic properties, concentration, and angular distribution of the platelets influence the final appearance of the coating. In this paper, we will present models for light scattering from front surface facet reflection, subsurface flake reflection, and diffuse subsurface scattering. Experimental scattering measurements on pearlescent coatings show that the polarization can be well described in different geometry regimes by these different scattering sources. The models can be used to extract the slope distribution function of the flakes from the intensity data, but some aspects of the results behave inconsistently. Comparison is also made between experimental and calculated diffuse reflectance spectra. These results are intended to enable improved characterization of special effect coatings necessary for quality control and appearance modeling applications.
Velocity, density and modulus of hydrocarbon fluids — data measurement (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Velocity, density and modulus of hydrocarbon fluids — data measurementAuthors: De‐hua HanM. BatzleDe‐hua HanHARC and M. BatzleCSMhttps://doi.org/10.1190/1.1815792 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1815792FiguresReferencesRelatedDetailsCited byUncertainty Quantification of Allen-Cahn Phase Field Parameters in Multiphysics Simulation of Oil Shale Radio Frequency Heating15 September 2021Uncertainty Quantification of an Explicitly Coupled Multiphysics Simulation of In-Situ Pyrolysis by Radio Frequency Heating in Oil Shale9 March 2020 | SPE Journal, Vol. 25, No. 03The Rock Physics Handbook5 March 2020 | , Vol. 54Scale effects on modelling the seismic signature of gas: results from an outcrop analogue4 June 2018 | Geophysical Prospecting, Vol. 66, No. 6Reservoir Structure and Wastewater-Induced Seismicity at the Val d'Agri Oilfield (Italy) Shown by Three-Dimensional V p and V p / V s Local Earthquake Tomography11 November 2017 | Journal of Geophysical Research: Solid Earth, Vol. 122, No. 11Processing Frequent 4D Land Seismic Data with Buried Sensors for CO2 Monitoring6 March 2017Geophysical Properties of the Near Surface Earth: Seismic PropertiesA technique for improving pseudo-synthetic seismograms generated from neutron logs in gas-saturated clastic rocks6 June 2013 | Journal of Geophysics and Engineering, Vol. 10, No. 3References29 August 2013CO2 velocity measurement and models for temperatures up to 200°C and pressures up to 100 MPaDe-Hua Han, Min Sun, and Micheal Batzle13 May 2010 | GEOPHYSICS, Vol. 75, No. 3Light oil measurement: density, velocity and modulus from 23 to 200°C and at pressures up to 150 MPaDe‐hua Han, Min Sun, Qiuliang Yao, and Jiajin Liu21 October 2010Time-Lapse Feasibility Analysis for a Brazilian Offshore Field: Target on Saturation and Pressure Changes InterpretationGuilherme F. Vasquez, Marcos S. dos Santos, Lúcia D. Dillon, Guenther S. Neto, and Paulo E. P. Marcondes14 September 2005Effects of pore fluid properties at high pressure and temperature on seismic responseJoel Walls and Jack Dvorkin7 December 2005Gassmann's equation and fluid‐saturation effects on seismic velocitiesDe‐hua Han and Michael L. Batzle1 April 2004 | GEOPHYSICS, Vol. 69, No. 2 SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION De‐hua Han and M. Batzle, (2000), "Velocity, density and modulus of hydrocarbon fluids — data measurement," SEG Technical Program Expanded Abstracts : 1862-1866. https://doi.org/10.1190/1.1815792 Plain-Language Summary PDF DownloadLoading ...
1041Early changes in regional heart function in Tgalphaq*44 murine model of dilated cardiomyopathy as assessed by CMR Tagging (2013)

Objectives: The aim of this work was to study early changes in regional systolic and diastolic left ventricle (LV) function during development of heart failure (HF) in unique murine model of dilated cardiomyopathy (Tgalphaq*44) with the use of LV circumferential strain (Ecc) assessment measured by Cardiac Magnetic Resonance (CMR) Tagging. Methods: Three groups of mice were examined: 2-months (N = 10) and 6-months (N = 7) Tgalphaq*44 mice and control FVB (2-months, N = 8). The LV short-axis imaging data included: single-slice mid-ventricular tagged images for Ecc assessment obtained with the use of Spatial Modulation of Magnetization and standard cine stack images (IntraGateFLASH) for global LV function (9.4 T Bruker BioSpec, Germany). Tagged images were analyzed using self-implemented Harmonic-Phase (HARP) algorithm. Ecc was evaluated over the whole cardiac cycle in 6 segments (according to 17-Segment Model). Ecc-based parameters were established: time-to-peak strain index TpeakSI, peak systolic strain Es, end-systolic strain Ees, peak post-systolic strain Epost, strain at the one-third of the diastolic duration E1/3DD, and compared to functional factors: ejection fraction EF and filling rate FR. Results: The averaged Ecc for Tgalphaq*44 groups vs. FVB showed significant (p < 0,05) decrease in Ees (from 17.2% to 15.6% in 2-mth, 13.9% in 6-mth Tgalphaq*44), Epost (from 17.2% to 15.5% in 2-mth, 13.9% in 6-mth Tgalphaq*44) and increase of TpeakSI (from 0.49 to 0.53 in 2-mths, 0.54 in 6-mths Tgalphaq*44). For the 6-mth Tgalphaq*44 Es and E1/3DD were reduced (from 18% to 14.8% and from 12.2% to 9.7%, respectively). These parameters revealed the same trend mostly within septal segments. The global function showed LV systolic impairment (EF from 71% in FVB to 61% in 2-mth and 58% in 6-mth Tgalphaq*44) while the diastolic global function was preserved (no changes in FR). Conclusion: CMR Tagging-based Ecc analysis revealed alterations in LV regional function in Tgalphaq*44 mice at early stages of HF. Systolic strain changes point to contractility impairment what corresponds to observed EF changes. Epost decay may reflect early stiffening and diastolic impairment development, also noticed in E1/3DD but not detected by global FR parameter. Acknowledgement: Work supported by the European Union from the European Regional Development Fund under the Innovative Economy Programme (grant coordinated by JCET-UJ, No POIG.01.01.02-00-069/09).
Investigation of the magnetic phase transition in chromium alloy using electrochemical techniques (1998)

The magnetic phase transition of chromium-0.2 at.% vanadium alloy was investigated using electrochemical methods. The temperature dependence of the potentiodynamic and open circuit potential data shows an anomalous behaviour close to the Neel temperature. This anomaly closely follows the shift of the Neel temperature due to alloying with vanadium. The transition is suppressed when the alloy is anodically oxidized, therefore the anomalies observed in the electrochemical parameters must be caused by the magnetic phase transition in the alloy itself. Electrochemical parameters, such as peak current density and zero-current potential, also present either distinct temperature dependences above and below the Neel temperature or anomalies around it.
Contribution of functionally assessed GHRHR mutations to idiopathic isolated growth hormone deficiency in patients without GH1 mutations (2019)

Isolated growth hormone deficiency (IGHD) is a rare condition mainly caused by mutations in GH1. The aim of this study was to assess the contribution of GHRHR mutations to IGHD in an unusually large group of patients. All GHRHR coding exons and flanking intronic regions were sequenced in 312 unrelated patients with nonsyndromic IGHD. Functional consequences of all newly identified missense variants were assessed in vitro (i.e., study of the expression of recombinant GHRHRs and their ability to activate the cyclic adenosine monophosphate (cAMP) signaling pathway). Genotype-phenotype correlation analyses were performed according to the nature of the identified mutation. We identified 20 different disease-causing GHRHR mutations (truncating and missense loss-of-function mutations), among which 15 are novel, in 24 unrelated patients. Of note, about half (13/24) of those patients represent sporadic cases. The clinical phenotype of patients with at least one missense GHRHR mutation was found to be indistinguishable from that of patients with bi-allelic truncating mutations. This study, which unveils disease-causing GHRHR mutations in 8% (24/312) of IGHD cases, identifies GHRHR as the second IGHD gene most frequently involved after GH1. The finding that 8% of IGHD cases without GH1 mutations are explained by GHRHR molecular defects (including missense mutations), together with the high proportion of sporadic cases among those patients, has important implications for genetic counseling.
Analysis of Interactions Stabilized by Fusicoccin A Reveals an Expanded Suite of Potential 14–3–3 Binding Partners (2020)

Fusicoccin A (FC) is a diterpene glycoside that stabilizes protein-protein interactions (PPIs) between 14-3-3 adapter proteins and their phosphoprotein interaction partners. Recently, FC has gained attention for its pro-apoptotic and neuroprotective properties in cell culture. Although the exact molecular mechanism(s) is (are) unresolved, 14-3-3 PPIs are central to this activity. With the goal of refining the pharmacology of this chemotype, we conducted a systematic analysis of the structural features that govern FC-induced stabilization of 14-3-3 PPIs utilizing a C-terminal phosphorylation recognition motif. This study confirmed that a C-terminal amino acid with a small alkyl group is required for the interaction of FC at canonical C-terminal 14-3-3 PPI interfaces. Using bioinformatics, this structural insight was leveraged to assemble a database of 119 candidate 14-3-3 PPIs that can serve as targets for FC. This group includes a subset of proteins with experimentally determined C-terminal phosphosites that have not been explored as potential targets of FC.
Fully planarized four-level interconnection with stacked vias using CMP of selective CVD-Al and insulator and its application to quarter micron gate array LSIs (2002)

The chemical mechanical polishing (CMP) of selective aluminum (Al) CVD via plugs is examined for the first time and a fully planarized four-level interconnection system with all stacked via plugs is demonstrated. A sandwich of Ti/TiN/Ti barrier layers with an Al-CVD plug has proved to be one of the best via plug structures because of its low via resistance and extremely high reliability. Quarter-micron 120-kG gate array LSIs have been successfully fabricated using a 1.4 /spl mu/m, equal pitch, four-level interconnection.
Real-Time Personal Monitoring in the Workplace Using Radio Telemetry (1992)

Abstract A system used to transmit data by radio from remote locations within a workplace to a personal computer for immediate interpretation has been developed. The system consists of several radio transmitters and a base receiver that is capable of multichannel reception. Exposure data obtained from any direct-reading instrument with an analog output signal can be displayed and stored at the computer. The worker being monitored carries the instrument in a backpack, along with a radio transmitter. Using telemetry, the concentration of the airborne contaminant under study can then be displayed on a video monitor for immediate assessment while being stored for later analysis. If there is more than one worker under study at a time, multiple exposure records can be displayed on the screen. The base receiver is a commercial (frequency) scanner that has been modified to accept RS-232 serial communication. The manual keypad has been removed so that channel selection is accomplished through system software. In terms of portability and convenience, the radio transmitter is similar to a wireless telephone. The radio telemetry system allows a worker unrestricted movement within its effective range. It also can be used to monitor up to five individual workers. A case study involving a furniture refinisher's exposure to methylene chloride is described here to demonstrate the utility of radio telemetry. The worker carried a radio transmitter that was attached to an air quality analyzer. Relative methylene chloride exposures were remotely observed on a video monitor throughout the day. Increases in exposure levels due to job tasks, work practices, and emission sources were immediately identified so that corrective action could be taken.
HEPATIC VITAMIN A FAT‐STORAGE CELLS AND THE METABOLISM OF CHYLOMICRON CHOLESTEROL (1976)

These experiments were designed to test the hypothesis that the vitamin A fat-storage cell removes chylomicron remnant cholesterol from hepatic portal venous blood; A modified Ficoll density gradient ultracentrifugation procedure was used to isolate from rat liver cellular fractions that were enriched in vitamin A. In rats fed a normal diet and in rats fed excess vitamin A isolated hepatocytes were fractionated 15 min after the intravenous injection of chylomicrons labelled in vivo with radioactive cholesterol. The results showed that cholesterol radioactivity was not concentrated in the vitamin A enriched cellular fractions, so it was concluded that the vitamin A fat-storage cell is not implicated in clearance of chylomicron remnants by the liver.
Metal Ion, Light, and Redox Responsive Interaction of Vesicles by a Supramolecular Switch (2014)

Chemical, photochemical and electrical stimuli are versatile possibilities to exert external control on self-assembled materials. Here, a trifunctional molecule that switches between an "adhesive" and a "non-adhesive" state in response to metal ions, or light, or oxidation is presented. To this end, an azobenzene-ferrocene conjugate with a flexible N,N'-bis(3-aminopropyl)ethylenediamine spacer was designed as a multistimuli-responsive guest molecule that can form inclusion complexes with β-cyclodextrin. In the absence of any stimulus the guest molecule induces reversible aggregation of host vesicles composed of amphiphilic β-cyclodextrin due to the formation of intervesicular inclusion complexes. In this case, the guest molecule operates as a noncovalent cross-linker for the host vesicles. In response to any of three external stimuli (metal ions, UV irradiation, or oxidation), the conformation of the guest molecule changes and its affinity for the host vesicles is strongly reduced, which results in the dissociation of intervesicular complexes. Upon elimination or reversal of the stimuli (sequestration of metal ion, visible irradiation, or reduction) the affinity of the guest molecules for the host vesicles is restored. The reversible cross-linking and aggregation of the cyclodextrin vesicles in dilute aqueous solution was confirmed by isothermal titration calorimetry (ITC), optical density measurements at 600 nm (OD600 ), dynamic light scattering (DLS), ζ-potential measurements and cyclic voltammetry (CV). To the best of our knowledge, a dynamic supramolecular system based on a molecular switch that responds orthogonally to three different stimuli is unprecedented.
Transient electropore lifetimes in skeletal muscle cells (1992)

Electroporation of skeletal muscle cell membranes has been postulated to cause myonecrosis in most victims of major electrical trauma. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(1,2)</sup> To precisely quantify membrane damage due to electroporation, we utilized a ratiometric fluorometric assay to determine the threshold of imposed transmembrane potential required to reversibly and irreversibly electroporate the cell membrane and calculated the time constants for electropores created over a wide range of applied fields.
Changes in the host lymphocyte subsets during chemical carcinogenesis. (1983)

Changes in small lymphocyte subsets in the lymphoid organs of young C3H mice were studied following i.m. injection of a carcinogenic dose of 3-methylcholanthrene in trioctanoin oil. Using monoclonal anti-Lyt antibodies and a sandwich radiolabeling method with 125I-labeled rabbit anti-mouse Immunoglobulin, the lymphocyte subpopulations in the thymus, spleen, and draining lymph node were examined by radioautography. During the fifth week following the administration of the carcinogen and prior to the appearance of histologically evident tumor cells, a sharp decrease in the level of Ly-1,2+ small lymphocyte population in the thymus was noted which coincided with a considerable increase (10-fold) in the Ly-2+ and a small increase (1.7-fold) in the Ly-1+ population. During the same period, a similar increase in the Ly-2+ population was also observed in the draining but not in the contralateral lymph node. The high levels of Ly-2+ cells lasted for more than 4 weeks in the thymus while, in the draining node, they lasted for 2 weeks and dropped to normal levels (0 to 2%) simultaneously with the appearance of tumor cells identified in histological preparations. Smaller increases (3-fold) in the Ly-2+ subset were also noted in the spleen and contralateral node, but they were seen later (7 to 8 weeks) and were shorter in duration. These systemic increases coincided with the appearance of macroscopic tumor nodules. The relative incidence of immunoglobulin+ cells did not change significantly in any of the organs tested during the entire tumor induction phase, while the level of null cells underwent a slight increase (approximately 2-fold) in all organs tested immediately prior to and following the appearance of macroscopic tumors. None of these changes was observed in trioctanoin oil-injected control animals. The mixed lymphocyte reaction response of the draining node cells, but not of the spleen, was suppressed during the period of increased level of Ly-2+ cells. Furthermore, during this period, s.c. transplantation of a syngeneic mammary tumor in the same leg resulted in enhanced local growth as well as metastatic spread of the tumor to the lungs in 3-methylcholanthrene-treated mice. These findings suggest that a localized immunosuppression associated with the rise in the Ly-2+ cells may be of functional significance during carcinogen-induced tumor development.
Compiling a partition-based two-level formalism (1996)

This paper describes an algorithm for the compilation of a two (or more) level orthographic or phonological rule notation into finite state transducers. The notation is an alternative to the standard one deriving from Koskenniemi's work: it is believed to have some practical descriptive advantages, and is quite widely used, but has a different interpretation. Efficient interpreters exist for the notation, but until now it has not been clear how to compile to equivalent automata in a transparent way. The present paper shows how to do this, using some of the conceptual tools provided by Kaplan and Kay's regular relations calculus.
[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling (2016)

// Laurence Booth 1 , Jane L. Roberts 1 , Mehrad Tavallai 1 , John Chuckalovcak 3 , Daniel K. Stringer 3 , Antonis E. Koromilas 5 , David L. Boone 4 , William P. McGuire 3 , Andrew Poklepovic 2 and Paul Dent 1 1 Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA 2 Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA 3 Department of Bio-Rad Laboratories, Hercules, CA, USA 4 Department of Microbiology and Immunology, Indiana University School of Medicine-South Bend, South Bend, IN, USA 5 Department of Oncology, Lady Davis Institute for Medical Research, Montreal, QC, Canada Correspondence to: Paul Dent, email: // Keywords : pemetrexed, sorafenib, ERBB1, PTEN Received : February 24, 2016 Accepted : March 15, 2016 Published : March 22, 2016 Abstract In the completed phase I trial NCT01450384 combining the anti-folate pemetrexed and the multi-kinase inhibitor sorafenib it was observed that 20 of 33 patients had prolonged stable disease or tumor regression, with one complete response and multiple partial responses. The pre-clinical studies in this manuscript were designed to determine whether [pemetrexed + sorafenib] –induced cell killing could be rationally enhanced by additional signaling modulators. Multiplex assays performed on tumor material that survived and re-grew after [pemetrexed + sorafenib] exposure showed increased phosphorylation of ERBB1 and of NFκB and IκB; with reduced IκB and elevated G-CSF and KC protein levels. Inhibition of JAK1/2 downstream of the G-CSF/KC receptors did not enhance [pemetrexed + sorafenib] lethality whereas inhibition of ERBB1/2/4 using kinase inhibitory agents or siRNA knock down of ERBB1/2/3 strongly promoted killing. Inhibition of ERBB1/2/4 blocked [pemetrexed + sorafenib] stimulated NFκB activation and SOD2 expression; and expression of IκB S32A S36A significantly enhanced [pemetrexed + sorafenib] lethality. Sorafenib inhibited HSP90 and HSP70 chaperone ATPase activities and reduced the interactions of chaperones with clients including c-MYC, CDC37 and MCL-1. In vivo , a 5 day transient exposure of established mammary tumors to lapatinib or vandetanib significantly enhanced the anti-tumor effect of [pemetrexed + sorafenib], without any apparent normal tissue toxicities. Identical data to that in breast cancer were obtained in NSCLC tumors using the ERBB1/2/4 inhibitor afatinib. Our data argue that the combination of pemetrexed, sorafenib and an ERBB1/2/4 inhibitor should be explored in a new phase I trial in solid tumor patients.