gebhart/patrepeval huggingface dataset:
Strength of polymethylmethacrylate increased by vacuum mixing (1984)

The mechanical strength of high and low viscosity gentamicin-containing cement was analysed using three different mixing procedures: hand, vibration, and vacuum stirring. Vacuum mixing improved the flexural and compression strength and the modulus of elasticity by 15-30 per cent, especially for high viscosity cement.
ChemInform Abstract: PYRIDINIUM MOLYBDATES. SYNTHESIS AND STRUCTURE OF AN OCTAMOLYBDATE CONTAINING COORDINATELY BOUND PYRIDINE: ((C5H5N)2MO8O26)4‐ (1985)

Abstract Die Titelverbindung (I) entsteht durch Behandlung von M0‐trioxiddihydrat mit einem Pyridinüberschuß bei 45°C (24 h).
HLA-G 3142C/G polymorphism is related to development of symptoms in HTLV-1 infected individuals (2014)

The majority of HTLV-1 infected individuals remain asymptomatic (HAC) throughout life, and the risk factors associated to the development of related diseases, such as HAM/TSP and ATL, are not fully understood. The human leukocyte antigen-G (HLA-G) is expressed in several pathological conditions and it has been associated to immunosuppressive effects allowing the virusinfected cells to escape of the host antiviral defense. Here, we evaluated the correlation between HLA-G polymorphisms in symptomatic and asymptomatic HTLV-1 infected individuals. Four polymorphisms of the exon 8 of the HLA-G gene were analysed by gene sequencing in HAC (n=48) and HAM/TSP patients (n=43). No difference was found between the groups for 3035C/T, 3187A/G and 3196C/G polymorphisms. On the other hand, despite of the absence of statistical significance, HAC group showed higher frequency of the 3142GG genotype (responsible for decreased transcription of theHLA-G) compared to HAM/TSP group (p=0,0607). Still, HAC group showed lower frequency of the 3142CC genotype (responsible for increased transcription of the HLA-G) compared to HAM/TSP group (p=0,0762). Furthermore, HAC group showed statistically higher frequency of the 3142G allele and lower frequency of the 3142C allele compared to HAM/TSP group (p=0,0244). In conclusion, HTLV-1-related symptoms in HAM/TSP group could be partially determined by higher expression of HLA-G (caused by higher frequency of the 3142C allele). We hypothesise that the higher expression of HLA-G protects the HTLV-1 infected cell against immune system attack the increasing proviral load and trigger the HAM/TSP symptoms. Financial support FUNDHERP, FAPESP and CNPq.
State Estimation Methods for Continuous-Discrete Nonlinear Systems involving Stochastic Differential Equations (2022)

In this work, we present methods for state estimation in continuous-discrete nonlinear systems involving stochastic differential equations. We present the extended Kalman filter, the unscented Kalman filter, the ensemble Kalman filter, and a particle filter. We implement the state estimation methods in Matlab. We evaluate the performance of the methods on a simulation of the modified four-tank system. We implement the state estimation methods for non-stiff systems, i.e., using an explicit numerical integration scheme. The implementation of the extended Kalman filter utilises the Joseph stabilising form for numerical stability. We evaluate the accuracy of the state estimation methods in terms of the mean absolute percentage error over the simulation horizon. We show that each method successfully estimates the states and unmeasured disturbances of the simulated modified four-tank system. Finally, we present conclusions.
A novel association of acquired ADAMTS13 inhibitor and acute dengue virus infection (2009)

Although the real incidence of dengue-related TMA is unknown, this case provides the basis for future epidemiologic studies on acquired ADAMTS13 deficiency in DV infection. The prompt clinical recognition of this complication and early installment of specific therapy with plasma exchange are likely to improve the outcome of severe cases of dengue.
Modulation spectrum based beamforming for speech enhancement (2017)

In array signal processing, beamforming is a common technique to align time differences between multi-microphone signals. Beamformers, however, have limits to reduce noise specially in the presence of reverberation. In this paper, we incorporate modulation properties of speech into a pre-processing algorithm to improve beamformer performance under combined noise-plus-reverberation conditions. In the modulation domain, signals are decomposed into modulators and carriers. Here, we propose to filter and perform short-time spectral subtraction of the modulator as a pre-processing step prior to beamforming, which in turn, is designed to align time differences between carriers of the array signal and to minimize the residual noise of the pre-processed signals. Simulation results with several noise-only and noise-plus-reverberation conditions show that the modulation pre-processing has improved the minimum power distortionless response beamformer by up to 7.4dB in the signal-to-noise ratio and 0.6 points in perceptual evaluation of speech quality (PESQ) score.
0π PULSE SHAPE IN THE SHARP LINE LIMIT CASE (1996)

We observe the propagation and the reshaping of low intensity (zero area) 60 fs pulses through high density atomic Cs vapor. The breakup of the pulses is measured for both resonant excitation of the Cs atoms and for laser detunings such that the atomic resonance frequency is in the wings of the pulse spectrum. The theory of 0π pulse propagation, in the extreme sharp-line limit, is extended to include both resonant and off resonant excitation. Good agreement is demonstrated between the observations and the theoretical predictions.
Study of rheological and mechanical performance of ultra-high-performance glass concrete (2017)

Fibre-reinforced concrete: From design to structural applications (PDF) <i>fib</i> Bulletins No. 79. Fibre-reinforced concrete: From design to structural applications. FRC 2014: ACI-fib International Workshop Proceedings - ACI SP-310 (480 pages, ISBN 978-2-88394-119-9, May 2016) - PDF format
P1‐046: BASELINE CHARACTERISTICS FROM CREAD2: A PHASE III TRIAL OF CRENEZUMAB IN EARLY (PRODROMAL‐TO‐MILD) ALZHEIMER'S DISEASE (2019)

Crenezumab is a humanized anti-amyloid-beta (Aβ) monoclonal IgG4 antibody currently in development for the treatment of Alzheimer's disease (AD). Crenezumab binds to monomeric and aggregated forms of Aβ, with high affinity for oligomers, protecting neurons from oligomer-induced toxicity. It is associated with a low risk of amyloid-related imaging abnormalities (ARIA). Whilst Phase II co-primary endpoints were not met, exploratory analyses suggested that crenezumab should be investigated for clinically meaningful efficacy at a higher dose and earlier stage of disease. Based on learnings from Phase II, two, global, randomized, double-blind, placebo-controlled, parallel-group Phase III studies (CREAD [NCT02670083];1 CREAD2 [NCT03114657]) are investigating the efficacy and safety of crenezumab (60 mg/kg, a 4-fold higher dose than that used in the Phase II trials) in patients with early (prodromal-to-mild) AD. CREAD baseline data have previously been presented.1 Patients aged 50–85 years with prodromal-to-mild AD and confirmed evidence of cerebral amyloid pathology (CSF or amyloid PET) were enrolled. At screening, patients had an MMSE score of ≥22, a CDR-global score of 0.5 or 1, Free and Cued Selective Reminding Test (FCSRT) immediate free recall ≤27 and cueing index ≤0.67 (to enrich for patients with greater likelihood of progression over 105 weeks), and were randomized 1:1 to placebo or crenezumab (60 mg/kg q4w IV). Randomization was stratified by dementia and APOE status, baseline anti-dementia medications, and geographic region. Primary and secondary endpoints include change from baseline in CDR-SB, ADAS-Cog-13, ADCS-ADL, and FAQ scores over 105 weeks. Exploratory objectives include assessing treatment effects on CSF biomarkers and amyloid- and tau-PET. MRI examinations are used to monitor safety and measure volumetric changes. CREAD2 has completed global recruitment, enrolling 784 patients. Enrollment in a China extension continues. Baseline characteristics for the global enrollment population in CREAD2 are similar to those of CREAD (data to be presented and compared with CREAD). The CREAD and CREAD2 Phase III trials are investigating the efficacy and safety of a 4-fold higher dose of crenezumab (vs. Phase II) in prodromal-to-mild AD. Both studies have completed global recruitment, enrolling similar populations. 1. Lin et al. AAIC 2018.
Preparation and properties of magnesium oxysulfate cement and its application as lost circulation materials (2021)

Loss of drilling fluids in large porous and fractured zones inevitably up-regulates the overall cost of drilling. As a type of acid-soluble cement, magnesium oxysulfate (MOS) cement is arousing huge attention for the less hygroscopic nature and less damaging to steel casings compared with magnesium oxychloride (MOC) cement. The present study developed MOS cement as a fast setting, high strength and acid-soluble lost circulation material to reduce the problem of losses. As suggested in this study, a higher strength of MOS cement at 70 °C could be achieved by elevating MgO/MgSO4·7H2O molar ratio or down-regulating H2O/MgSO4·7H2O molar ratio. Boric acid and borax could act as effective retarders. Plugging slurry based on MOS cement could effectively block the simulated porous loss zones exhibiting a diameter from 1.24 mm to 1.55 mm, as well as the fractured loss zones with a width from 2 mm to 5 mm and bearing a pressure difference up to 8 MPa. Permeability recovery test demonstrated that it facilitated future oil and gas production. The successful field application in the Junggar Basin, Xinjiang, China verified the significant plugging effect of MOS cement for severe loss problems.
Acetonitrile-hydrochloric acid hydrolysis of gangliosides for high performance liquid chromatographic analysis of their long chain bases. (1983)

An improved method for the hydrolysis of long chain bases from gangliosides with aqueous acetonitrile-HCl is described. The long chain bases released from brain gangliosides were derivatized with biphenylcarbonylchloride and resolved by high performance liquid chromatography on a C18 reversed-phase column. Components of individual peaks were identified by gas-liquid chromatography-mass spectrometry as their trimethylsilyl derivatives. The acetonitrile-HCL hydrolysis procedure resulted in no formation of O-methyl ethers of long chain bases and a significant decrease in the level of secondary products.
Control of Spotted Wing Drosophila in Blueberries, 2014: Table 1 (2015)

5a,5a1,7a,8,9,10-decahydro-3,5-dihydroxy-4-{(1S,3S,7S,8R,9S,11R)-7hydroxy-9-methyl-2,4, 10-trioxatetracyclo[6.3.1.03,7.09,11]
The Use of Thermography in Determining Viability of Pedicle Flaps (1969)

One of the basic skills of the reconstructive surgeon involves the shifting of soft tissues from an area of relative surplus to one where a deficit has been caused by trauma, surgical ablation of tumors, or disease processes. Largely by the use of trial and error methods, certain donor areas have been found which can supply this tissue over the course of one or more stages of delivery. The time honored delay of three weeks has served admirably as a rough yardstick of the requisite time for vascularization of a pedicle flap when moved to a new position, thus allowing detachment to be performed. Certain highly vascular areas, such as the face, have been found to support detachment of pedicle flaps in somewhat less time than this; whereas less vascular areas, such as the lower third of the leg, may well require a more prolonged period of vascular equilibration before
13. Analysis of Anisotropic Velocities in a Core Sample and AVOA from a Fractured Vuggy Carbonate Reservoir (2001)

We investigate the effects of fracture-and inclusion-induced seismic anisotropy in a carbonate reservoir rock and the resulting influence this anisotropy may have on surface seismic data.Whole-core velocity measurements made on a carbonate sample from the Gulf of Mexico show evidence of elastic anisotropy.Constraints on the style of this anisotropy are obtained from comparisons with effective medium modeling.The core exhibits monoclinic symmetry, which is interpreted as being caused by the combined effects of vertically-aligned drilling-induced fractures and oriented ellipsoidal vugs inclined at an of angle roughly to the vertical.The in situ anisotropy is believed to be orthorhombic, as there is evidence of natural fractures oriented orthogonally to the vugs.Surface seismic modeling is used to investigate amplitude variations with offset and azimuth (AVOA) effects due to such anisotropy.Our model is somewhat hypothetical, but consistent with velocities from the reservoir logs and the inferred in situ anisotropy.Our results suggest that for this model, P-wave AVOA will show significant azimuthal variation only at far offsets (near critical reflections).In fact, the onset of critical reflections will be dependent on the orientation of the seismic line with respect to the fracture direction.Shear modes will be more sensitive to fracture orientation at near offsets.In addition, we find that the P-P and P-S AVOA are sensitive to the presence of aligned vuggy porosity and so could provide a tool for identifying highly productive zones where fractures connect vugs.
A novel damage-free high-k etch technique using neutral beam-assisted atomic layer etching (NBALE) for sub-32nm technology node low power metal gate/high-k dielectric CMOSFETs (2009)

For the first time, a novel damage-free neutral beam-assisted atomic etching process has successfully demonstrated the removal of the residual high-k dielectric layer after gate patterning. Due to its neutralized atomic flux and chemical reaction, high etch selectivity is observed to improve device performance and reliability. This process should significantly enhance high-k/metal gate manufacturability.
Emerging self-powered piezoelectric based nanobiomaterials as a platform for accelerated wound healing: recent advances and future perspectives (2023)

AbstractSpontaneous generation of native endogenous electric fields (EFs) after wounding is the hallmark of enhanced wound healing (WH). Focus has been given toward creation of smart technologies that provide an external EF. Piezoelectric based dressings when applied to wound sites can conveniently generate EF in response to body's natural movement and promote WH. In this perspective, piezoelectric nanobiomaterials are gaining significant attention due to their high surface energy and complex cell-material interactions. This review discusses role of EF in WH simultaneously exploring their development and use for skin regeneration. Important properties of these materials and future directions are also discussed.Keywords: Wound healingpiezoelectricitynanobiomaterialselectrical stimulation AcknowledgmentsAuthors are thankful to School of Applied Sciences, KIIT Deemed to be University. S. Pattnaik would like to thank the Council of Scientific & Industrial Research (CSIR), Government of India, for providing a junior research fellowship.Conflict of interestThe authors declare no conflict of interest.
[P101]: Apolipoprotein E, angiotensin‐converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia (2006)

Alzheimer's disease (AD) and vascular dementia (VaD) are the most prevalent forms of dementia. Lipoproteins and vascular factors may play roles in the development of AD and/or VaD. In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE) and kallikrein (KLK1) polymorphisms were computed to test their association with the disease by a case–control study and a promoter functional assay. The analysis of genotype or allele frequency distribution of KLK1 −130 GN showed no statistically significant difference between cases and controls. The overall APOE genotype distribution was significantly different between the AD cases and controls (p < 0.0001), with significantly more ɛ3ɛ4 (35.8% versus 16.8%, p = 0.0010) and ɛ4ɛ4 (8.6% versus 0.0%, p = 0.0002) genotypes among AD cases and the association of the ɛ4 allele with AD was evident (p < 0.0001; OR: 3.73; 95% CI: 2.38–5.98). The above difference was not observed between the VaD cases and controls. The risk of AD was also significant for people with ACE DD genotype, D allele or T–D haplotype [OR (95% CI) = 4.29 (1.96–10.23), 1.90 (1.35–2.70) or 2.91 (1.71–5.10), respectively]. The above association between ACE-VaD was also strong (p = 0.0012, 0.0050, 0.0007, respectively). Reporter constructs containing the −240 A or T allele displayed similar transcriptional activity in both HEK-293 and IMR-32 cells. Thus, another putative pathogenic marker that is linked with the Alu D allele might affect the risk of AD and VaD in Taiwan.
Effectiveness of the Direct Renin Inhibitor, Aliskiren, in Patients With Resistant Hypertension (2013)

Currently there is no consensus regarding which add-on therapy to use in resistant hypertension. We have conducted an open observational study of the use of aliskiren in resistant hypertensive patients. Forty-three patients with resistant hypertension were included in the study. The inclusion criteria were as follows: 1) office blood pressure (BP) > 140/90 mmHg despite treatment with at least three or more antihypertensive drugs; 2) no prior therapy with aliskiren; and 3) no renal insufficiency. Follow-up BP was determined at 1 and 3 months. Baseline BP was 153 ± 12/79 ± 12 mmHg. After 3 months, systolic BP (SBP) and diastolic BP (DBP) dropped significantly: 140 ± 19/73 ± 13 mmHg (P < 0.0001). Twenty-one patients (49%) had an office BP < 140/90 mmHg, and these patients were assigned to the good BP control group. Another 22 were placed into the poor BP control group. BP reductions from baseline in the good BP control group (SBP/ DBP: 19 ± 11/8 ± 7 mmHg) were larger than those in the poor BP control group (5 ± 15/3 ± 9 mmHg, P < 0.05). Mean BP (MBP) values at baseline, 1, and 3 months were higher in the poor BP control group. There was no significant difference in pulse pressure at baseline between the 2 groups. In multivariate analysis, only MBP at baseline correlated with lack of BP control. Aliskiren administration to resistant hypertensive patients was effective in reducing BP. The present findings suggest aliskiren may be useful as a fourth-line or fifth-line treatment added to other drugs in the treatment of resistant hypertension.
Interspecific activity of the sex pheromone of the European shore crab (Carcinus maenas) (2008)

The recent identification of uridine diphosphate (UDP) as the female sex-pheromone in the European shore crab Carcinus maenas demonstrated not only the link between moult and pheromone production, but also how it may have evolved from a 'simple' metabolic byproduct. Consequently, it is expected to be present in other moulting crustaceans, thus raising issues involving species specificity of the female pheromone. Bioassays were conducted using synthetic pheromone (UDP, 10(-3)-10(-4) M) to examine if it induced sexual behaviour in other crustacean species that are neither closely related nor occur in the same ecosystem. The snow crab, Chionoecetes opilio, and the yellowline arrow crab, Stenorhynchus seticornis, both belonging to a different superfamily (Majoidea) and occurring in different habitats than C. maneas (Portunoidea), displayed significant sexual behaviour towards UDP treated objects (p < 0.005). These and other examples demonstrate that the female sex-pheromone UDP is not species-specific but is present and active in some other decapod crustaceans.
Defunctioning Stoma Reduces Symptomatic Anastomotic Leakage After Low Anterior Resection of the Rectum for Cancer: A Randomized Multicenter Trial (2008)

Veenhof, Alexander A.F.A. MD; van der Peet, Donald L. MD, PhD; Meijerink, Wilhelmus J.H.J. MD, PhD; Cuesta, Miguel A. MD, PhD Author Information
High-accuracy distance measurements with multiple-wavelength interferometry (1995)

Multiple-wavelength interferometry is, like classical interferometry, a coherent method, but it offers great flexibility in sensitivity by an appropriate choice of the different wavelengths and it can be operated on rough surfaces. The accuracy of this method depends essentially on the signal processing and on the properties of the source. Practical considerations for distances in the range of several meters with micrometer resolution are given.
Comparisons of Transport and Dispersion Model Predictions of the Mock Urban Setting Test Field Experiment (2006)

Abstract The potential effects of a terrorist attack involving the atmospheric release of chemical, biological, radiological, nuclear, or other hazardous materials continue to be of concern to the United States. The Defense Threat Reduction Agency has developed a Hazard Prediction Assessment Capability (HPAC) that includes initial features to address hazardous releases within an urban environment. Improved characterization and understanding of urban transport and dispersion are required to allow for more robust modeling. In 2001, a scaled urban setting was created in the desert of Utah using shipping containers, and tracer gases were released. This atmospheric tracer and meteorological study is known as the Mock Urban Setting Test (MUST). This paper describes the creation of sets of HPAC predictions and comparisons with the MUST field experiment. Strong consistency between the conclusions of this study and a previously reported HPAC evaluation that relied on urban tracer observations within the downtown area of Salt Lake City was found. For example, in both cases, improved predictions were associated with the inclusion of a simple empirically based urban dispersion model within HPAC, whereas improvements associated with the inclusion of a more computationally intensive wind field module were not found. The use of meteorological observations closest to the array and well above the obstacle array—the sonic anemometer measurements 16 m above ground level—resulted in predictions with the best fit to the observed tracer concentrations. The authors speculate that including meteorological observations or vertical wind profiles above or upwind of an urban region might be a sufficient input to create reasonable HPAC hazard-area predictions.
Nitrogen bridgehead compounds. Part 45 [1]. Synthesis of 6‐arylhydrazono‐6,7,8,9‐tetrahydro‐11H‐pyrido‐[2,1‐b]quinazolin‐11‐ones (1984)

Abstract A series of 6‐arylhydrazono‐6,7,8,9‐tetrahydro‐11 H ‐pyrido[2,1‐ b ]quinazolin‐11‐ones 3–37 , conveneint starting materials for indolopyridoquinazolines, were prepared by diazonium coupling between aryldiazonium chlorides and 6,7,8,9‐tetrahydro‐ 2 , 6‐formyl‐5,7,8,9‐tetrahydro‐ 39 , 6‐(dimethylamino)methylene‐6,7,8,9‐ 38 or 6‐carboxyl‐5,7,8,9‐tetrahydro‐11 H ‐pyrido[2,1‐ b ]quinazolin‐11‐ones 43 . The arylhydrazono derivatives were also prepared from 6‐bromo‐ 45 or 6,6‐dibromo‐6,7,8,9‐tetrahydro‐11 H ‐pyrido[2,1‐ b ]quinazolines 46 with arylhydrazines. The structures of the 6‐arylhydrazonopyridoquinazolines were characterized by uv and 1 H nmr spectroscopy. The 6‐arylhydrazono derivatives show a solvent‐dependent E‐Z isomerism.
Development of an algorithm for using PINP to monitor treatment of patients with teriparatide (2005)

The PINP algorithm provides information regarding the anabolic response to teriparatide therapy and has the potential to identify patients requiring help with issues of adherence, injection technique, teriparatide storage, and medical problems limiting therapeutic responsiveness to teriparatide treatment. Data assessing the relationship of changes in PINP to fracture risk reduction are not available. We recommend physicians audit the use of the algorithm in practice so that improvements can be made.