gebhart/patrepeval huggingface dataset:
Blood pressure development of the spontaneously hypertensive rat after concurrent manipulations of dietary Ca2+ and Na+. Relation to intestinal Ca2+ fluxes. (1985)

The blood pressure of the spontaneously hypertensive rat (SHR) is influenced by the Ca2+ content of its diet. As the SHR's greater dependence on dietary calcium may reflect a defect in intestinal calcium absorption, we measured in vitro unidirectional Ca2+ flux (J) in the duodenum-jejunum (four segments each) of the SHR (n = 6) and the normotensive Wistar-Kyoto rat (WKY; n = 6) by a modified Ussing apparatus. Because of the known and postulated interactions between Ca2+ and Na+ in both intestinal and vascular tissue, we assessed in vivo the influence of a concurrent manipulation of Na+ intake (three levels: 0.25%, 0.45%, and 1.0%) on the blood pressure development of SHRs (n = 35) and WKYs (n = 35), between 6 and 20 wk of age, exposed to three levels of dietary calcium (0.1, 1.0, and 2%). Net calcium flux (Jnet) (mean +/- SEM) was significantly (P less than 0.01) lower in the SHR (-2.8 +/- 6.3 nmol/cm2 X h) than in the WKY (34.6 +/- 8.8 nmol/cm2 X h). The SHR's decreased Jnet resulted from a significantly (P less than 0.03) lower mucosa-to-serosa flux (Jm-s) in the SHR (41.0 +/- 5.6 nmol/cm2 X h) compared with the Jm-s of the WKY (70.1 +/- 9.1 nmol/cm2 X h). Serosa-to-mucosa flux for calcium did not differ between the SHR (43.8 +/- 6.6 nmol/cm2 X h) and the WKY (35.5 +/- 8.0 nmol/cm2 X h). The SHR's decreased (P less than 0.002) Jm-s was confirmed by additional measurements in SHRs and WKYs. Jm-s was 36.2 +/- 3.7 nmol/cm2 X h in the SHRs (n = 11) and 64.4 +/- 6.7 nmol/cm2 X h in the WKYs (n = 9). The provision of an increased dietary Ca2+ (2% by weight) and increased Na+ (1%) to the SHR prevented the emergence of hypertension (P less than 0.001) (mean +/- SEM systolic blood pressure at 20 wk of age; 135 +/- 5 mmHg for the 2% Ca2+, 1% Na+ SHR vs. 164 +/- 2 mmHg for the control diet SHR). Ca2+ (0.1%) and Na+ (0.25%) restriction accelerated the SHR's hypertension (192 +/- 2 mmHg) (P less than 0.001) and was associated with higher pressures in the WKY (146 +/- 4 mmHg in the restricted WKY vs. 134 +/- 4 mmHg in the control WKY). In a parallel group of 24 SHRs and 24 WKYs fed one of three diets (2% Ca2+/1% Na+; 1% Ca2+/0.45% Na+; or 0.1% Ca2+/0.25% Na+), the heart (P < 0.05) and kidney (P = 0.08) weight of the SHRs varied depending on the diet at 20 wk of age. Low Ca2+ and Na+ intake was associated with increased heart weight (1.6+/-0.9 g) compared with the normal diet for SHR (1.51+/-0.07 g). Increased Ca2+ and Na+ intake was associated with a significantly (P = 0.05) lower heart weight in the SHR (1.37+/-0.03 g) and in the WKY (1.35+/-0.06 g) compared with their normal diet controls. These findings show one mechanism for the SHR's depressor response to supplemental dietary Ca2+ and, in part, explain the sodium dependence of calcium's cardiovascular protective effect.
Tunable Nanoresonators Constructed from Telescoping Nanotubes (2006)

We have created a tunable mechanical nanoscale resonator with potential applications in precise mass, force, position, and frequency measurement. The device consists of a specially prepared multiwalled carbon nanotube (MWNT) suspended between a metal electrode and a mobile, piezo-controlled contact. By exploiting the unique telescoping ability of MWNTs, we controllably slide an inner nanotube core from its outer nanotube casing, effectively changing its length and tuning its flexural resonance frequency.
Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists (2011)

Thyroid Stimulating Hormone (TSH) is a heterodimeric glycoprotein hormone that regulates thyroid homeostasis upon interaction with the TSH receptor (TSHR). TSH binds to the TSH receptor, which couples preferentially to the G-alpha (s) (Gs) protein, resulting in activation of adenylate cyclase and increase in cyclic adenosine 3′, 5′ monophosphate (cAMP). In this report, we describe the discovery and SAR studies of a series of dihydroquinazolin-4-ones as TSHR agonists. ML109 (CID-25246343) is the first selective and orally available small-molecule TSHR agonist, and the probe will be a useful pharmacological tool to study TSHR biology in thyroidal and extrathyroidal tissues.
High‐order methods for low Reynolds number flows around moving obstacles based on universal meshes (2015)

Summary We propose a family of methods for simulating two‐dimensional incompressible, low Reynolds number flow around a moving obstacle whose motion is prescribed. The methods make use of a universal mesh: a fixed background mesh that adapts to the geometry of the immersed obstacle at all times by adjusting a few elements in the neighborhood of the obstacle's boundary. The resulting mesh provides a conforming triangulation of the fluid domain over which discretizations of any desired order of accuracy in space and time can be constructed using standard finite element spaces together with off‐the‐shelf time integrators. We demonstrate the approach by using Taylor‐Hood elements to approximate the fluid velocity and pressure. To integrate in time, we consider implicit Runge‐Kutta schemes as well as a fractional step scheme. We illustrate the methods and study their convergence numerically via examples that involve flow around obstacles that undergo prescribed deformations. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Oral mucosal analgesia quantitatively assessed by argon laser-induced thresholds and single-evoked vertex potentials. (1993)

The aim of this study is to quantitate the efficacy of a new topical anesthetic applied to the oral mucosa. Nociceptive pinprick thresholds and single-evoked vertex potentials (VP) elicited by high-intensity argon laser stimuli are used as measures of analgesia. After 5 minutes of occlusion (Orahesive Oral Bandages, ConvaTec) with a eutectic mixture of local anesthetics (EMLA cream, Astra), nociceptive pinprick thresholds on the tongue and gingiva are higher than those taken during nonocclusion. In a double blind-placebo controlled experiment, VPs were elicited every 1 minute for 19 minutes by single laser stimuli applied to the mucosa of the lower lip. After occlusion with EMLA cream for 3 minutes, VPs were significantly reduced when compared to those with placebo cream. One minute after removal of the EMLA cream, the spectral power of the single-evoked VP decreased significantly by 63.3%, the root-mean-square amplitude decreased by 42.7%, and the subjective pain perception (estimated on visual analogue scales) decreased by 88%. A significant reduction in single-evoked VPs was detected until 13 minutes after the removal of the EMLA cream. Oral mucosal analgesia may be quantitated by argon laser-induced nociceptive pinprick thresholds and single-evoked VPs.
A Search for Inhibitors of Prostate Growth Stimulators (1957)

No AccessJournal of Urology1 Apr 1957A Search for Inhibitors of Prostate Growth Stimulators William Wallace Scott, William J. Hopkins, Wendell M. Lucas, and Charles Tesar William Wallace ScottWilliam Wallace Scott More articles by this author , William J. HopkinsWilliam J. Hopkins Present address: Henry Ford Hospital, Detroit, Mich. More articles by this author , Wendell M. LucasWendell M. Lucas American Cancer Society Clinical Fellow. Present address: Howard University School of Medicine, Washington, D. C. More articles by this author , and Charles TesarCharles Tesar More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)66615-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1957 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByScott W and Wade J (2018) Medical Treatment of Benign Nodular Prostatic Hyperplasia with Cyproterone AcetateJournal of Urology, VOL. 101, NO. 1, (81-85), Online publication date: 1-Jan-1969.Woodruff M and Perez-Mesa C (2018) The Effect of Hormonal Modification on Prostatic MorphologyJournal of Urology, VOL. 88, NO. 2, (273-280), Online publication date: 1-Aug-1962.Woodruff M and Umiker W (2018) The Effect of Estrogen and Androgen on the Rat Prostate Gland and TestesJournal of Urology, VOL. 84, NO. 1, (162-166), Online publication date: 1-Jul-1960.Marden H, Moon K and Milner W (2018) Inhibition of Endogenous Androgenic Response in the Rat By 19-nor-17-ethyl TestosteroneJournal of Urology, VOL. 82, NO. 5, (617-618), Online publication date: 1-Nov-1959. Volume 77Issue 4April 1957Page: 652-659 Advertisement Copyright & Permissions© 1957 by The American Urological Association Education and Research, Inc.MetricsAuthor Information William Wallace Scott More articles by this author William J. Hopkins Present address: Henry Ford Hospital, Detroit, Mich. More articles by this author Wendell M. Lucas American Cancer Society Clinical Fellow. Present address: Howard University School of Medicine, Washington, D. C. More articles by this author Charles Tesar More articles by this author Expand All Advertisement PDF DownloadLoading ...
Northern Blot Analysis of Gene Expression (2003)

In the analysis of gene expression, the steady-state level of RNA transcripts is one of the most convenient parameters used to monitor the activity of an endogenous or introduced gene in cell lines and tissues. A variety of methods, such as Sl hybridization (Chapter 21, this vol), RNase protection (Chapter 22), and Northern blotting, can be used to measure RNA levels. Which assay system is best depends largely on the type of information required, levels of sensitivity, and limitations of the particular in vivo system being examined. This chapter details the method for analyzing RNA by Northern blotting, which basically involves the isolation of RNA, its size fractionation by electrophoresis, transfer to a membrane, and detection by nucleic acid hybridization and autoradiography.
Safety, Tolerability, and Effectiveness of Oxymorphone Extended Release for Moderate to Severe Osteoarthritis Pain (2005)

A 52-week, multicenter, open-label extension study was performed to evaluate the safety, tolerability, and effectiveness of oxymorphone extended release (ER), a novel tablet formulation of oxymorphone hydrochloride, in 153 patients with moderate to severe chronic osteoarthritis-related pain. Sixty-one patients (39.9%) completed the study. Common opioid-related nonserious adverse events (AEs) caused most withdrawals. However, approximately one-half of withdrawals due to AEs were among opioid-naive patients who received placebo in a previous trial and were started on a dose of 20 mg every 12 hours, suggesting that tolerability can be improved by titrating from a lower initial dose. Mean pain scores initially decreased as previously opioid-naive patients achieved adequate pain relief, reached stable levels after the first 6 weeks, and remained stable at mild levels throughout the remainder of the study (average pain, 20-25 mm on 100-mm Visual Analog Scale). Average daily dosing remained stable throughout the study (median, 40 mg/d). At each assessment, at least 80% of patients rated their global satisfaction with oxymorphone ER as "excellent," "very good," or "good." Oxymorphone ER provides a new 12-hour analgesic for the treatment of moderate to severe chronic osteoarthritis-related pain in patients who may require long-term opioid therapy.
Image Processing of Electron Micrographs for Light Scattering Calculations (1993)

Theoretical light scattering calculations, when applied to models based on structures seen in electron micrographs of corneal stroma, require knowledge of the constituent fibril positions and radii. Obtaining this information manually is a difficult and time-consuming task. In order to facilitate this problem, we present a simple and flexible computer algorithm that allows the process to be automated using a Macintosh computer. The accuracy of the results is checked by comparing light scattering calculations using fibril positions and radii found manually with those found by the computer. The results show that the computer algorithm is a viable and accurate means of obtaining the needed data.
Study the Quality Assurance of Conventional X-ray Machines Using Non Invasive KV meter (2010)

The aim of the present paper is to investigate some factors affecting on quality assurance of conventional x-ray such as reproducibility of tube voltage, dose out put, time, and x-ray tube efficiency, Accuracy of kVp, mA, time, and focal spot size. and half value layer.Examinations of these factors are studied using non invasive kV meter NeroMax 8000 which connected with suitable ionization chambers. The quality assurance tests of X-ray diagnostic examination are measured and compared with the international tolerance.
Supplementary Table S4 from Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment (2023)

&lt;p&gt;Flow cytometry correlations.&lt;/p&gt;
Active Vibration Absorption Using Delayed Resonator With Relative Position Measurement (1995)

Abstract A novel active vibration absorption technique, the Delayed Resonator, has been introduced recently as a unique way of suppressing undesired oscillations. It suggests a control force on a mass-spring-damper absorber in the form of a proportional position feedback with a time delay. Its strengths consist of extremely simple implementation of the control algorithm, total vibration suppression of the primary structure against a harmonic force excitation and full effectiveness of the absorber in a semi-infinite range of disturbance frequency, achieved by real-time tuning. All this development work was done using the absolute displacements of the absorber in the feedback. These displacement measurements may be difficult to obtain and for some applications impossible. This paper deals with a substitute and easier measurement: the relative motion of the absorber with respect to the primary structure. Theoretical foundations for the Delayed Resonator (DR) are briefly recapitulated and its implementation on a single-degree-of-freedom primary structure disturbed by a harmonic force is introduced utilizing both absolute and relative position measurement of absorber mass. Methods for stability range analysis and transient behavior are presented. Properties acquired for the same system with these two different feedback are compared. Relative position measurement case is found to be more advantageous in most applications of the Delayed Resonator method.
Structural Chemistry of Bismuth Compounds. I. Organobismuth Derivatives (1999)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Chemistry of Bismuth Compounds. I. Organobismuth DerivativesCristian Silvestru, Hans Joachim Breunig, and Henrik AlthausView Author Information Facultatea de Chimie, Universitatea Babes-Bolyai, RO-3400 Cluj-Napoca, Romania Institut für Anorganische und Physikalische Chemie, Universität Bremen, Postfach 330440, D-28334 Bremen, Germany Cite this: Chem. Rev. 1999, 99, 11, 3277–3328Publication Date (Web):October 8, 1999Publication History Received2 March 1999Revised2 June 1999Published online8 October 1999Published inissue 10 November 1999https://pubs.acs.org/doi/10.1021/cr980083qhttps://doi.org/10.1021/cr980083qresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views2595Altmetric-Citations207LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bismuth,Ligands,Mathematical methods,Molecular structure,Reaction products Get e-Alerts
Phosphatidylglycerophosphate synthases from Arabidopsis thaliana (2001)

Two Arabidopsis thaliana genes were shown to encode phosphatidylglycerophosphate synthases (PGPS) of 25.4 and 32.2 kDa, respectively. Apart from their N‐terminal regions, the two proteins exhibit high sequence similarity. Functional expression studies in yeast provided evidence that the 25.4 kDa protein is a microsomal PGPS while the 32.2 kDa protein represents a preprotein which can be imported into yeast mitochondria and processed to a mature PGPS. The two isozymes were solubilized and purified as fusion proteins carrying a His tag at their C‐terminus. Enzyme assays with both membrane fractions and purified enzyme fractions revealed that the two A. thaliana isozymes have similar properties but differ in their CDP‐diacylglycerol species specificity.
Whole-Mount Immunohistochemistry of Short-Tailed Fruit Bat (Carollia perspicillata) (2009)

INTRODUCTION This protocol describes whole-mount immunohistochemistry of short-tailed fruit bat ( Carollia perspicillata ) embryos. This method is used for direct visualization of the expression pattern of a protein of interest within embryos fixed at a wide range of developmental stages. It has been used with good results on embryos at stages from CS 11 through CS 15.
Induced parasexual processes in Claviceps sp. strain SD58 (1987)

A homokaryotic, clavine alkaloid-producing strain of ergot, Claviceps sp. strain SD 58, was used in an attempt to demonstrate parasexuality. Genetically marked auxotrophic strains were produced by mutation with N-methyl-N'-nitro-N-nitrosoguanidine. Protoplast fusion of pairs of unlike doubly auxotrophic strains and isolation of stable prototrophic fusion products were carried out. By growth of the fusion products on complete medium, selective pressure for prototrophy was removed and auxotrophic segregants were allowed to form. Analysis of these and recovery of segregants with nonleaky, non-parent-type combinations of auxotrophic characteristics has provided strong evidence that a parasexual cycle can function in Claviceps sp. strain SD 58. Preliminary work suggests that the genetics of ergot might be studied by mitotic analysis and that protoplast fusion and selection procedures might be useful for the enhancement of favorable characteristics in Claviceps strains.
Effect of Outer Edge Flame on Flame Extinction in Counterflow Diffusion Flames (2012)

대향류확산화염의 화염소화에 있어서 에지화염 역할에 관한 실험적 연구가 진행되었다. 속도비, 버너직경, 그리고 버너간격을 변화시키며 수행된 실험에서 전체신장률에 따른 화염소화 임계질소몰분율의 그래프는 c-커브 형태로 나타났다. 고신장률화염에서는 화염소화 임계질소몰분율의 그래프가 하나의 곡선으로 일치하였으며, 화염이 일차원의 응답특성을 갖는 것을 확인하였다. 화염 소화는 바깥 에지화염이 반경방향으로의 진동 후에 화염 중심으로 수축하며 소화하는 영역, 진동 없이 화염중심으로 수축하며 소화하는 영역, 그리고 바깥 에지부분의 수축과 진동 없이 화염중심에 화염 구멍이 생기며 소화하는 영역으로 세 가지 모드로 나타났다. 화염 표면온도 측정과 에너지 방정식의 각항을 수치해석 한 결과를 토대로 에지화염부분에서의 반경방향 전도 열손실이 에지화염의 불안정을 야기한다는 것과 전도를 통한 열 공급뿐만 아니라 대류를 통한 열 공급도 바깥 에지화염의 안정화에 기여한다는 것을 보였다. 그리고 반경방향의 전도열손실이 수축하며 소화하는 메커니즘의 지배적인 역할을 함을 보였다.
DNA Damage and Repair: Fruit and Vegetable Effects in a Feeding Trial (2010)

Epidemiologic studies have examined the association between fruit and vegetable (F&V) consumption and the risk of cancer. Several cancer-preventive mechanisms have been proposed, such as antioxidant properties and modulation of biotransformation enzyme activities; both may be associated with reducing DNA damage and hence the mutation rate. We investigated, in a randomized, controlled, crossover feeding trial, the effect of 10 servings/day of botanically defined F&V for 2 wk on endogenous DNA damage; resistance to gamma -irradiation damage; and DNA repair capacity in lymphocytes, measured by the Comet assay. We also explored the association between the UGT1A1*28 polymorphism and serum bilirubin concentrations and DNA damage and repair measures. Healthy men (n = 11) and women (n = 17), age 20 to 40 yr, provided blood samples at the end of each feeding period. Overall, F&V did not affect DNA damage and repair measures in lymphocytes. The number of UGT1A1*28 alleles was inversely associated with sensitivity to gamma -irradiation exposure and DNA repair capacity, but a biological mechanism to explain this association is unclear. A larger sample size is needed to investigate the association between bilirubin concentrations and endogenous DNA damage. With inconsistent findings in the literature, additional dietary intervention studies on the effect of F&V on DNA damage and repair are needed.
The Derivation of Failure Event Correlation Based on Shadowing\n Cross-Correlation (2019)

In this document we derive the mapping between the failure event correlation\nand shadowing cross-correlation in dual connectivity architectures. In this\ncase, we assume that a single UE is connected to two gNBs (next generation\nNodeB).\n
Association of candidate gene polymorphisms with milk technological traits, yield, composition, and somatic cell score in Italian Holstein-Friesian sires (2017)

Advances in DNA-based marker technology have enabled the identification of genomic regions underlying complex phenotypic traits in livestock species. The incorporation of detected quantitative trait loci into genetic evaluation provides great potential to enhance selection accuracies, hence expediting the genetic improvement of economically important traits. The objective of the present study was to investigate 96 single nucleotide polymorphisms (SNP) located in 53 candidate genes previously reported to have effects on milk production and quality traits in a population of highly selected Holstein-Friesian bulls. A total of 423 semen samples were used to genotype the bulls through a custom oligo pool assay. Forty-five SNP in 32 genes were found to be associated with at least 1 of the tested traits. Most significant and favorable SNP trait associations were observed for polymorphisms located in CCL3 and AGPAT6 genes for fat yield (0.037 and 0.033 kg/d, respectively), DGKG gene for milk yield (0.698 kg/d), PPARGC1A, CSN1S1, and AGPAT6 genes for fat percentage (0.127, 0.113, and 0.093%, respectively), GHR gene for protein (0.064%) and casein percentage (0.053%), and TLR4 gene for fat (0.090%), protein (0.066%), and casein percentage (0.050%). Somatic cell score was favorably affected by GHR (-0.095) and POU1F1 (-0.137), and interesting SNP-trait associations were observed for polymorphisms located in CSN2, POU1F1, and AGPAT6 genes for rennet coagulation time (-0.592, -0.558, and -0.462 min, respectively), and GHR and CSN2 genes for curd firmness 30 min after rennet addition (1.264 and 1.183 mm, respectively). In addition to the influence of individual SNP, the effects of composite genotypes constructed by grouping SNP according to their individual effects on traits considered in the analysis were also examined. Favorable and significant effects on milk traits were observed for 2 composite genotypes, one including 10 SNP and the other 4 SNP. The former was associated with an increase of milk (0.075 kg/d), fat (0.097 kg/d), protein (0.083 kg/d), and casein yields (0.065 kg/d), and the latter was associated with an increase of fat (0.244%), protein (0.071%), and casein percentage (0.047%). Although further research is required to validate the identified SNP loci in other populations and breeds, our results can be considered as a preliminary foundation for further replication studies on gene-assisted selection programs.