gebhart/patrepeval huggingface dataset:
Effect of Rotation and Knee Flexion on Radiographic Alignment in Total Knee Arthroplasties (1996)

A synthetic femur and tibia were used to create a model resurfacing total knee arthroplasty. The femoral component was placed in 7 degrees valgus; the tibial component was placed in 2 degrees varus with a 5 degrees posterior slope. The overall anatomic alignment was 5 degrees valgus. A series of radiographs were taken on 14 inch x 17 inch plates, in full extension and 10 degrees flexion, with the limb rotated, in 5 degree increments, from 20 degrees external rotation to 25 degrees internal rotation. Seven orthopaedic surgeons independently measured the tibiofemoral angle and tibial alignment for each series of radiographs; interobserver variability was insignificant. Average radiographic anatomic alignment ranged from 2.29 degrees valgus in 20 degrees external rotation and 10 degrees flexion, to 6.73 degrees valgus in 25 degrees internal rotation and 10 degrees flexion. Limb rotation and knee flexion of 10 degrees, either alone or in combination, had a highly statistically significant effect on measured values of the anatomic alignment. Tibial alignment ranged from 5 degrees varus in 20 degrees external rotation to 3 degrees valgus in 25 degrees internal rotation, with the knee flexed 10 degrees. The variability associated with changes in rotation was statistically significant. Changes associated with rotation, when the knee was flexed 10 degrees, were not significantly different than those measured with the knee fully extended. Even in a well aligned total knee arthroplasty, limb positioning at the time of radiographic assessment will alter the apparent alignment indices, making objective evaluation difficult.
An Investigation Into the Compliance of SCARA Robots. Part I: Analytical Model (1988)

A special class of robots suited for assembly tasks called SCARA (Selective Compliance Assembly Robot Arm) provides a degree of built-in flexibility due to robot structure. In such robots there are three revolute joints and a prismatic joint. They offer four degrees of freedom consisting of rotation about two vertical and parallel axes at the revolute joints, and translation and rotation about the tool axis. Some models offer additional degrees of freedom at the end effector. Structural compliance can arise due to the stiffness of the robot links, drive system, grippers as well as the assembled parts. The largest effect is due to the drive torsional stiffness followed by the grippers, workpieces and the robot tool link. Knowledge of the inherent flexibility is extremely useful in designing tooling and fixtures, in laying out the assembly work cell according to the amount of compliance available in various regions of the robot work envelope, in guarding against wedging and jamming and in specifying external Remote Centre Compliance devices (RCC) if necessary. In this paper the various sources of compliance built into a SCARA robot system are outlined together with their relative significance. A mathematical model which expresses the end effector deflection as a function of the robot Jacobian and the drive compliance parameters in Cartesian coordinates has been developed. The modified generalized assembly force model developed for the Selective Compliance Assembly Robot Arms (SCARA), used in this investigation, is described. Constraints required to prevent jamming and wedging of parts during assembly are outlined. The application of this compliance model for both rotational and prismatic part insertion is described. The conditions required to obtain true or semi-compliance centres for the SCARA robot end effector are derived and discussed.
Informer et former pour lutter contre la stigmatisation : les premiers secours en santé mentale (2019)

Pensée et action sont articulées chez Canguilhem. Si on les inscrit dans le contexte de l’entre-deux-guerres et en les comparant aux trajectoires de contemporains tels que Cavaillès, Rougier et Sartre, l’engagement de Canguilhem pendant la guerre, ainsi que la forme d’action choisie deviennent intelligibles, si, évitant l’essentialisme, on les analyse à la lumière de la notion de disposition, de l’appartenance à des réseaux de sociabilité et de son âge, éléments qui guident autant la propension à prendre des risques que le contenu de ses prises de position.
Targeting Autophagy Addiction in Cancer (2011)

Autophagy inhibition is a novel cancer therapeutic strategy in the early stages of clinical trial testing. The initial rationale for using autophagy inhibition was generated by research revealing that autophagy is upregulated in response to external stresses, including chemotherapy and radiotherapy. Combining autophagy inhibition with agents that induce autophagy as a pro-survival response may therefore increase their therapeutic efficacy. Recent research has shown that some cancer cells, particularly those driven by the K-Ras oncogene, also depend on elevated levels of autophagy for survival even in the absence of external stressors. In multiple in vitro as well as in vivo systems, oncogenic Ras-mediated transformation and tumor growth are dependent on autophagy to evade metabolic stress and cell death. These studies have subsequently led to further early phase clinical testing whether autophagy inhibition is a viable and effective strategy for targeting Ras-driven tumors. Even before the clinical results are available from these ongoing clinical trials, much work remains to optimally develop the approach of autophagy inhibition clinically; most notably reliably detecting levels of autophagy in human tumor samples, pharmacodynamics of currently available autophagy inhibitors (chloroquine and the derivative hydroxychloroquine), and new target identification and drug development.
Sentinel-1 Radar Interferometry Applications (2008)

The short revisit time in the ERS Tandem experiment shows the data quality reachable when the temporal coherence is high. Sentinel 1 will have a revisit time of 12 days. Using the 3 days repeat data from the ice phase of ERS1, we evaluated the improvements for distributed scatterers interferometry. Slow ground motion, visible in many successive images, allows the estimation of the subsidence rate from the interferogram stacks and not only from Persistent Scatterers. Interferograms at multiple spans can be optimally combined. The dispersion of the subsidence rate estimate obtained in one year using interferogram stacks compares favourably to a PS, if the number of pixels used is greater than say 100. We compare the Cramér Rao bound for the subsidence estimates for a Markov model of the temporal decorrelation to an approximated optimal linear estimate found from the covariances of the interferograms at different spans. The unbiased subsidence rate estimates are consistent
Multi-resolution Probabilistic Ocean Physics-Acoustics Modeling: Validation in the New Jersey Continental Shelf (2020)

The reliability of sonar systems in the littoral environment is greatly affected by the variability of the surrounding nonlinear ocean dynamicS. This variability occurs on multiple scales in space and time, and involves multiple interacting processes, from internal tides and waves to meandering fronts, eddies, boundary layers, and strong air-sea interactionS. We utilize our high-resolution MSEAS-PE ocean modeling system to hindcast the ocean physical environment off the New Jersey continental shelf for the end of June 2009, and then utilize our new MSEAS probabilistic acoustic NAPE and WAPE solvers in a coupled ocean physics-acoustic modeling fashion to predict the transmission and integrated transmission losses, respectively. The coupled models are described, and their predictions verified against independent ocean physics observations and sound propagation measurements from acoustic sources and receivers in the region. Our high-resolution ocean simulations are shown to substantial reduce the RMSE and bias of the coarser simulationS. Our acoustic simulations of deterministic and stochastic TL fields also show significant skill.
Glassy carbon and graphite electrodes with a hole for long path length thin-layer spectroelectrochemistry (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlassy carbon and graphite electrodes with a hole for long path length thin-layer spectroelectrochemistryMarc D. Porter and Theodore. KuwanaCite this: Anal. Chem. 1984, 56, 3, 529–534Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://doi.org/10.1021/ac00267a051RIGHTS & PERMISSIONSArticle Views222Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (755 KB) Get e-Alerts Get e-Alerts
Consistent control of psoriasis by continuous long‐term therapy: the promise of biological treatments (2006)

Abstract Psoriasis is a chronic, incurable disease that frequently requires long‐term treatment. Although many patients benefit from effective traditional systemic therapies, namely methotrexate, cyclosporin, retinoids and fumaric acid esters, and some patients achieve long‐term disease control, unrestricted long‐term administration is not recommended due to the potential for cumulative toxicity. In order to diminish the risk of toxicity, physicians have adopted various treatment approaches (e.g. rotational, sequential, intermittent, and combination). However, these approaches may not provide continuous disease control or a stable treatment regimen. The recent advent of targeted biological therapeutics such as etanercept, infliximab, adalimumab, alefacept and efalizumab may offer physicians and their patients treatment options with improved safety profiles that may permit continuous disease control.
Evolved Packet System (EPS): The LTE and SAE Evolution of 3G UMTS (2008)

2G/GSM and 3G/UMTS are key mobile communication technologies, chosen by more than 2 billion people around the world. In order to adapt to new services, increasing demand for user bandwidth, quality of service and requirements for convergence, major evolutions are introduced in 3G standard. Evolved Packet System (EPS) presents the EPS evolution of the 3G/UMTS standard introduced by the 3rd Generation Partnership Project (3GPP) standard committee. This new topic is looked at from a system perspective, from the to and service architecture. Hundreds of documents being issued by Standard organisations are summarised in one book to allow the reader to get an accessible comprehensive view of EPS evolution. Proposes a system view of Evolved UMTS, from the to Core and service architecture Gives a comprehensive and global view of the system that technical specifications do not provide Describes the new system as well as the inheritance and migration from 2G/GSM and 3G/UMTS Written by experts in the field who specialise in two complementary but very different technical domains (i.e. radio interface and network architecture) Contains many figures and examples for better understanding. This book is essential for industry professionals in the telecommunication business, telecommunication system architects and designers, product manufacturers and operators and postgraduate students.
Site-Specific Manifestations of Invasive Group A Streptococcal Disease: Type Distribution and Corresponding Patterns of Virulence Determinants (2003)

As part of a national surveillance program on invasive group A streptococci (GAS), isolates that caused specific manifestations of invasive GAS disease in The Netherlands were collected between 1992 and 1996. These site-specific GAS infections involved meningitis, arthritis, necrotizing fasciitis, and puerperal sepsis. An evaluation was performed to determine whether GAS virulence factors correlate with these different disease manifestations. PCRs were developed to detect 9 genes encoding exotoxins and 12 genes encoding fibronectin binding proteins. The genetic backgrounds of all isolates were determined by M genotyping and pulsed-field gel electrophoresis (PFGE) analysis. The predominant M types included M1, M2, M3, M4, M6, M9, M12, and M28. Most M types were associated with all manifestations of GAS disease. However, M2 was found exclusively in patients with puerperal sepsis, M6 predominated in patients with meningitis, and M12 predominated in patients with GAS arthritis. While characteristic gene profiles were detected in most M types, the resolution of detection of different gene profiles within M genotypes was enhanced by PFGE analysis, which clearly demonstrated the existence of some clonal lineages among invasive GAS isolates in The Netherlands. M1 isolates comprised a single clone carrying highly mitogenic toxin genes (speA, smeZ) and were associated with toxic shock-like syndrome. Toxin profiles were highly conserved among the most virulent strains, such as M1 and M3.
Finite element computation of electric field and charge density of a pulsed energized electrostatic precipitator (2002)

This paper numerically analyzes the governing equations in pulsed energized wire-duct electrostatic precipitators (WDEP). The electric field along its spatial distribution and the voltage-current characteristics are evaluated in the presence of dust. The finite element method (FEM) and a modified method of characteristics are used to solve the time-dependent Poisson's equation and to satisfy the current continuity condition, respectively. The two methods are repeated iteratively to obtain a self-consistent solution of the describing equations. The effect of pulse rate variation on the computed results is also investigated. Comparing the computed results with previously obtained experimental and calculated values tests the effectiveness of this approach. The agreement with experimental results is found to be satisfactory.
Mechanical and Thermal Properties of Glass Reinforced Composites (2022)

In our Pulsed Field Facility, we use epoxy fillers to create smooth, strong winding transitions between layers of coils in our consumable pulsed magnets. For structural support, we often use materials like G10, a high-pressure fiberglass laminate consisting of multiple glass layer cloths soaked in epoxy. In liquid nitrogen, such materials have good mechanical and dielectric strength. To accommodate gaps at transitions, epoxy fillers typically have complex shapes, which render their fabrication expensive and time-consuming. In addition, the machining of epoxies like G10 can be hazardous. In this study, we replaced machining with 3D printing, using thermo-plastic, strengthened by glass fiber, as the raw material. Polyether Ether Ketone (PEEK) material as well as nylon material were used as the matrix. The strengthening components were chopped E-glass fibers or beads. We found that 3D printing can significantly reduce manufacturing cost for our magnets. Because our magnets must operate between 77 K and 295 K, we measured mechanical and thermal properties for both the nylon and the PEEK composites at both temperatures. The measured direction of the samples was parallel to the printing direction. The measured maximum compressive strength was about 258 MPa. Although the strength is lower than G10, the techniques we developed in this study would apply to 3D printing technology for various cryogenic applications like winding transition or experimental probes that are not exposed to very high stress in high field magnets.
A Computational Framework for Boundary Representation of Solid Sweeps (2014)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
The Brugada Syndrome. (2005)

In 1992 a syndrome was described consisting of syncopal episodes and/or (resuscitated) sudden death in patients with a structurally normal heart and a characte ristic electrocardiogram (ECG) displaying a pattern resembling a right bundle branch block with ST segment elevation in leads V1 to V3. The disease is genetically determined with an autosomal dominant pattern of transmission in 50% of the familial cases. Several different mutations have been identified affecting the structure, function and trafficking of the sodium channel. The syndrome is ubiquitous. Its incidence and prevalence are difficult to estimate, but this disease may cause 4 to 10 sudden deaths per 10,000 inhabitants per year representing the most frequent cause of natural death in males younger than 50 in South Asia. The disease has been linked to the sudden infant death syndrome (SIDS) and to the sudden unexpected death syndrome (SUDS) by showing that the electrocardiogram and mutations are the same as in Brugada syndrome. The diagnosis is easily made by means of the ECG when it is typical. There exist, however, patients with concealed and intermittent electrocardiographic forms that make the diagnosis difficult. The ECG can be modulated by changes in autonomic balance, body temperature, glucose level and the administration of antiarrhythmic, neuroleptic and antimalaria drugs. Beta adrenergic stimulation normalizes the ECG. Loss of the action potential dome in right ventricular epicardium but not in endocardium underlies the ST segment elevation. Electrical heterogeneity within right ventricular epicardium leads to the development of closely coupled extrasystoles via phase 2 reentry that precipitate ventricular ,fibrillation. Antiarrhythmic drugs do not prevent sudden death in symptomatic or asymptomatic individuals. Implantation of an automatic cardioverter-defibrillator is the only currently proven effective therapy. Patients with frequent electrical storms may even need cardiac transplantation as last resort.
Quantitative Mineralogy of Fine-grained Sedimentary Rocks: A Preliminary Look at QEMSCAN® (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
A low cost solution for laboratory experiments in induction motor control (2003)

In this paper we present a controller suitable for educational activities in electric drives. A prototype has been designed specifically to meet the requirement of low cost and it contains all of the active functions required to implement the open loop control of an induction motor. In this way, the prototype allows the easy assimilation of important concepts and enables the understanding of the enclosed subsystems. Some experiments that highlight the quality of the proposed approach are presented.
SUCCESSFUL TRANSPLANTATION OF CYCLOSPORINE-TREATED HAPLOIDENTICAL LIVING-RELATED RENAL RECIPIENTS WITHOUT BLOOD TRANSFUSIONS (1984)

A protocol of cyclosporine and prednisone immunosuppression was used in 36 consecutive haploidentical living-related renal transplant recipients from donors displaying marked proliferation in mixed lymphocyte culture (MLC) reactions. All blood transfusions (random third-party and donor-specific) were withheld once a negative crossmatch with the prospective kidney donor was obtained. With a mean follow-up of 13.6 months, patient survival is 97% (35/36) and graft survival is 92% (33/36). One graft was lost to rejection; two were abandoned because of sepsis. Only 14% (5/36) of patients experienced a rejection episode. No significant differences were evident in graft survival, rejection episodes, or renal function between the 15 recipients who were never transfused and the 21 with a history of previous blood transfusions. These findings suggest that pretransplant blood transfusions not only are unnecessary to achieve excellent graft survival, but also may jeopardize donor availability by donor-specific presensitization.
Expression Profiling of Human Epidermal Keratinocyte Response Following 1-Minute JP-8 Exposure (2006)

The cDNA microarray analysis of 9600 expressed sequence tags was performed to examine the gene expression changes in human epidermal keratinocytes after 1-minute JP-8 exposure; 151 genes were identified as JP-8 responsive and classified into 8 clusters by self organization map. Genes involved in basal transcription and translations were up-regulated, whereas genes related to DNA repair, metabolism, and keratin were mostly down-regulated. Genes encoded for growth factors, apoptosis, signal transduction, and adhesion were also altered. These results indicated that human keratinocyte responds to a single dose of JP-8 insult and revealed several cellular processes previously not associated with jet fuel exposure.
Structural Stability and Dynamics of Hydrogenated and Perdeuterated Cytochrome P450cam (CYP101) (2004)

Perdeuterated and hydrogenated cytochrome P450cam (P450cam), from Pseudomonas putida, has been characterized concerning thermal stability and structural dynamics. For the first time, Fourier transform infrared (FTIR) spectroscopy was used to characterize a perdeuterated protein. The secondary structure compositions were determined from the fitted amide I' spectral region, giving band populations at 10 degrees C for the perdeuterated protein of 22% between 1605 and 1624 cm(-1) (beta-sheets), 47% between 1633 and 1650 cm(-1) (alpha-helix (29%) plus unordered/3(10)-helix (18%)), and 28% between 1657 and 1677 cm(-1) (turns) and for the hydrogenated protein of 22% between 1610 and 1635 cm(-1) (beta-sheets), 52% between 1640 and 1658 cm(-1) (alpha-helix (41%) plus unordered/3(10)-helix (11%)), and 24% between 1665 and 1680 cm(-1) (turns). Thermal unfolding experiments revealed that perdeuterated P450cam was less stable than the hydrogenated protein. The midpoint transition temperatures were 60.8 and 64.4 degrees C for the perdeuterated and hydrogenated P450cam, respectively. Step-scan time-resolved FTIR was applied to the P450cam-CO complex to study the ligand-rebinding process after flash photolysis. Rebinding of the ligand occurred with the same kinetics and rate constants k(on), 8.9 x 10(4) and 8.3 x 10(4) M(-1) s(-1) for the perdeuterated and hydrogenated P450cam, respectively.Perdeuterated P450cam was expressed for a neutron crystallographic study to determine the specific hydration states and hydrogen-bonding networks at the active site. The analyses presented here show that perdeuterated P450cam is structurally similar to its hydrogenated counterpart, despite its reduced thermal stability, suggesting that information obtained from the neutron structure will be representative of the normal hydrogenated P450cam.