gebhart/patrepeval huggingface dataset:
In vivo light dosimetry during whole bladder wall PDT (1988)

A system has been developed for in vivo monitoring and control of light dose rate and dose during whole bladder wall photodynamic therapy (PDT). Through a modified cystoscope three transparent plastic catheters (1-mm i.d.) can be introduced into the bladder cavity and unfolded into three directions, ~120° apart, along the bladder wall. Into each catheter a miniature isotropic light dosimetry probe is inserted. The fibers of these probes are connected to an electronic readout system with displays for energy fluence rate and integrated light dose. The cystoscope also admits an isotropic light source connected to a laser for irradiation. The readings of the three light dosimetry probes are used to optimize the position of the light source in the optical center of the bladder and to monitor its position during treatment. The uniformity of the irradiation across the bladder wall can also be checked and adjusted. Measurements in vivo confirm that the true energy fluence rate at the bladder wall is 5–6 times the irradiance of unscattered light (wavelength, 625–630 nm). Measurements during treatment show that controlling the light source position by intravesical ultrasound does not guarantee a uniform light dose distribution across the bladder wall.
MULTISCALING COEFFICIENTS TECHNIQUE FOR GAIN ERROR BACKGROUND CALIBRATION IN PIPELINED ADC (2013)

This paper presents a multiscaling coefficient technique for convergence speed boosting in pipelined analog-to-digital converter (ADC) with noisy-signal-based gain error background calibration. By detecting the monotonicity of calculated gain error, the convergence process of the system can be divided into several phases. Each phase is then applied with different scaling coefficients, so rapid convergence speed and stable calibration system can be accomplished simultaneously. The time cost on convergence process can be reduced significantly, and stable calibration system has been simulated during the ADC's normal operation.
Mechanism of Permanganate-Promoted Dihydroxylation of Complex Diketopiperazines: Critical Roles of Counter-cation and Ion-Pairing (2018)

The mechanism of permanganate-mediated dual C-H oxidation of complex diketopiperazines has been examined with density functional theory computations. The products of these oxidations are enabling intermediates in the synthesis of structurally diverse ETP natural products. We evaluated, for the first time, the impact of ion-pairing and aggregation states of the permanganate ion and counter-cations, such as bis(pyridine)-silver(I) (Ag<sup>+</sup>) and tetra- n-butylammonium (TBA<sup>+</sup>), on the C-H oxidation mechanism. The C-H abstraction occurs through an open shell singlet species, as noted previously, followed by O-rebound and a competing OH-rebound pathway. The second C-H oxidation proceeds with a second equivalent of oxidant with lower free energy barriers than the first C-H oxidation due to directing effects and the generation of a more reactive oxidant species after the first C-H oxidation. The success and efficiency of the second C-H oxidation are found to be critically dependent on the presence of an ion-paired oxidant. We used the developed mechanistic knowledge to rationalize an experimentally observed oxidation pattern for C<sup>3</sup>-indole-substituted diketopiperazine (+)-5 under optimal oxidation conditions: namely, the formation of diol (-)-6 as a single diastereomer and lack of the ketone products. We proposed two factors that may impede the ketone formation: (i) the conformational flexibility of the diketopiperazine ring, and (ii) hindrance of this site, making it less accessible to the ion-paired oxidant species.
Prediction of bacterial meningitis in children with meningeal signs: reduction of lumbar punctures (2001)

This prediction rule identifies about 35% of the patients with meningeal signs in whom a lumbar puncture can be withheld without missing a single case of bacterial meningitis. For the individual patient this prediction rule is valuable in deciding whether or not to perform a lumbar puncture.
A Two-Stage Efficient 3-D CNN Framework for EEG Based Emotion Recognition (2022)

This paper proposes a novel two-stage framework for emotion recognition using EEG data that outperforms state-of-the-art models while keeping the model size small and computationally efficient. The framework consists of two stages; the first stage involves constructing efficient models named EEGNet, which is inspired by the state-of-the-art efficient architecture and employs inverted-residual blocks that contain depthwise separable convolutional layers. The EEGNet models on both valence and arousal labels achieve the average classification accuracy of 90%, 96.6%, and 99.5% with only 6.4k, 14k, and 25k parameters, respectively. In terms of accuracy and storage cost, these models outperform the previous state-of-the-art result by up to 9%. In the second stage, we binarize these models to further compress them and deploy them easily on edge devices. Binary Neural Networks (BNNs) typically degrade model accuracy. We improve the EEGNet binarized models in this paper by introducing three novel methods and achieving a 20% improvement over the baseline binary models. The proposed binarized EEGNet models achieve accuracies of 81%, 95%, and 99% with storage costs of 0.11Mbits, 0.28Mbits, and 0.46Mbits, respectively. Those models help deploy a precise human emotion recognition system on the edge environment.
Abstract 5371: A pooled apoptome shRNA screen to identify pathways that enhance NVP-BEZ235-induced apoptosis (2011)

Abstract NVP-BEZ235 is a dual inhibitor of class 1 phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) catalytic activity. It induces cell death in a subset of breast cancer cell lines characterized by amplification of human epidermal growth factor receptor 2 (HER2/ErbB2) and/or activating PIK3CA mutations, but not in cell lines with loss of function of the PTEN tumor suppressor protein or KRAS mutations. In order to better understand the molecular mechanisms leading to cell death, to identify potential biomarkers of activity and to reveal pathways that may even enhance NVP-BEZ235 induced lethality, a pooled short hairpin RNA (shRNA) screen using a lentiviral-based shRNA library targeting the apoptome was performed in NVP-BEZ235-sensitive MDA-MB453 and HCC1954 breast cancer cells. This strategy led to the identification of shRNAs that sensitized cells to NVP-BEZ235-induced apoptosis. Top sensitizers included pro-survival BCL2 family members, BCL2L1 and MCL1. Validation studies were carried out with single shRNAs targeting BCL2L1 and MCL1 as well as drug combination studies of NVP-BEZ235 with ABT-263 or ABT-747, both BCL2 homology domain 3 (BH3)-only protein mimetics. Cell death assays and biochemical readouts including PARP cleavage support the use of BCL2 family inhibitors to enhance NVP-BEZ235-induced cell death in HER2 amplified/PIK3CA mutated breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5371. doi:10.1158/1538-7445.AM2011-5371
Spot-based mode coupler for mode-multiplexed transmission in few-mode fiber (2012)

We present designs for a low-loss mode coupler based on multiple Gaussian spots that can selectively address spatial and polarization modes of a few-mode fiber. In particular we show a design optimized for a few-mode fiber with 12 spatial and polarization modes (LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> , the twofold degenerate LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> and LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> , and LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">02</sub> ), with a mode dependent loss <;1dB and coupler insertion loss <;3dB.
LAPAROSCOPIC CROSS-TRIGONAL COHEN URETERONEOCYSTOSTOMY: NOVEL TECHNIQUE (2001)

Laparoscopic transvesical cross-trigonal antireflux ureteral reimplantation is technically feasible. Intravesical laparoscopic suturing is possible. Potential advantages include a decreased hospital stay, decreased narcotic requirement and better cosmesis. Further experience is necessary to refine the technical nuances and evaluate outcomes compared to the open technique.
Marijuana Is Associated With a Hormonal Imbalance Among Several Habits Related to Male Infertility: A Retrospective Study (2022)

Marijuana is one of the most consumed drugs worldwide. There is increasing evidence of an association between marijuana and male infertility. This study intends to assess the repercussion of marijuana smoking and other habits (sedentary lifestyle, alcohol, and tobacco use) in the testicular function of infertile men seeking andrological evaluation. A retrospective study was performed using medical records data of men aged 18-59 years from 2009 to 2017. Complete semen analyses, sperm functional tests, SHBG, and hormonal levels, testosterone-to-estradiol ratio (T/E<sub>2</sub>), and testis volume were evaluated. Exclusion criteria included cryptorchidism, infertility caused by genetic or infectious diseases, and cancer. A multiple linear regression analysis was performed to investigate which habit could predict certain parameters using the software SPSS 23.0 (<i>P</i> < 0.05). In a sample of 153 men, semen parameters, testosterone levels, and testis volume were not significantly influenced. Marijuana use had the broader hormonal changes since it influences estradiol (<i>P</i> = 0.000; <i>B</i> = -11.616), prolactin (<i>P</i> = 0.000; <i>B</i> = 3.211), SHBG levels (<i>P</i> = 0.017; <i>B</i> = 7.489), and T/E<sub>2</sub> (<i>P</i> = 0.004; <i>B</i> = 14.030). Sedentary lifestyle (<i>P</i> = 0.028; <i>B</i> = 1.279) and tobacco smoking (<i>P</i> = 0.031; <i>B</i> = -2.401) influenced the prolactin levels. Marijuana is associated with hormonal imbalance in this infertile cohort by lowering estradiol levels and inhibiting aromatase function.
High-performance analog photo receiver for millimeter-wave radio-over-fiber applications (2014)

We have developed a high-conversion-gain analog photo receiver for millimeter-wave radio-over-fiber applications. The performance was tested with an optical back-to-back configuration at a symbol rate of 1.76-2.2 Gbaud in π/2-shift BPSK and 16-QAM at a single carrier frequency of 32 GHz.
A Parameterized Action Representation for Virtual Human Agents (1998)

We describe a Parameterized Action Representation (PAR) designed to bridge the gap between natural language instructions and the virtual agents who are to carry them out. The PAR is therefore constructed based jointly on implemented motion capabilities of virtual human figures and linguistic requirements for instruction interpretation. We will illustrate PAR and a real-time execution architecture controlling 3D animated virtual human avatars.
Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients (2002)

Diffuse noxious inhibitory control (DNIC) is part of a central pain modulatory system that relies on spinal and supraspinal mechanisms. Previous studies have shown that fibromyalgia (FMS) patients are lacking DNIC effects on experimental pain, compared to normal control (NC) subjects. Because DNIC has a greater effect on second pain than on first pain, we hypothesized that wind-up (WU) of second pain should be attenuated by a strong conditioning stimulus. Thus, we compared DNIC's effect on WU in three groups of subjects: 11 NC males, 22 NC females, and 11 FMS females. To separately assess the contributions of distraction related mechanisms to inhibition of second pain, we designed the experiment in such a way that directed the subjects' attention to either the test or conditioning stimulus. Repeated heat taps to the thenar surface of the right hand were used as test stimuli to generate WU of second pain. Immersion of the left hand into a hot water bath was the conditioning stimulus. As previous experiments have shown, DNIC requires a strong conditioning stimulus for pain attenuation, which may be at least partly dependent on a distraction effect. DNIC significantly inhibited thermal WU pain in normal male subjects, but adding distraction to the DNIC effect did not increase the extent of this inhibition. In contrast, neither DNIC nor DNIC plus distraction attenuated thermal WU pain in female NCs. DNIC plus distraction but not DNIC alone produced significant inhibition of thermal WU pain in female FMS patients. Our results indicate that DNIC effects on experimental WU of second pain are gender specific, with women generally lacking this pain-inhibitory mechanism.
Getting a chemical handle on proteinpost-translational modification (2009)

This article highlights the emerging field of chemical proteomics, a powerful technology for the study of post- and co-translational modification of proteins. Genome mapping and the study of protein post-translational modifications have revealed the astounding chemical complexity present in the proteome of even the simplest organisms. The identification and characterisation of the modifications present on specific proteins in such complex mixtures has become a central challenge for post-genomic functional studies in cell and systems biology. In the chemical proteomic approach to this problem, protein-modifying enzymes and bioorthogonal chemoselective elaboration are exploited to deliver chemical tags to specific modified residues, enabling new advances in our understanding of protein modification.
Graft-Versus-Host Disease (GVHD) After Double-Unit Cord Blood Transplantation (DCBT) Is Associated with Unique Clinical Features Including a Higher Incidence of Grade III-IV Acute GVHD (aGVHD) in Children (2012)

GVHD is a serious complication and common cause of transplant-related mortality after DCBT. However, relatively little is known about DCBT GVHD manifestations, treatment response, and risk factors. We evaluated 108 DCBT recipients (median 37 years, range 0.9-69) transplanted for high-risk hematologic malignancies with myeloablative (n = 81) or non-myeloablative (n = 27) conditioning, 4-6/6 HLA-matched grafts, calcineurin-inhibitor/mycophenolate mofetil, and no ATG. With a median follow-up of 28 months, the cumulative incidences of day 180 grade II-IV and III-IV aGVHD were 52% (95%CI:42-62) and 24% (95%CI:15-32), respectively. The median onset was 40 days (range 14-161), and the gut was most commonly affected (43/54, 80%). Twenty-five patients with mainly grade II gut aGVHD were treated with budesonide alone, 26 patients with predominantly grade III-IV aGVHD received systemic corticosteroids, and treatment response was achieved in over 80% by day 56 of therapy. However, 41 patients had active GVHD after day 100 with the majority (61%) having aGVHD, particularly of the gut. Classical chronic GVHD was uncommon. Univariate analysis of the association between patient/graft characteristics and grade III-IV aGVHD showed the only significant factor associated with a higher severe aGVHD incidence was age 0-15 years. Multivariate Cox regression analysis was performed (Table). Younger age was independently associated with a higher severe aGVHD incidence whereas better engrafting unit-recipient 8-9/10 HLA-allele match was protective. There was a trend toward better unit-unit HLA-match being associated with worse aGVHD, but, surprisingly, total infused TNC/kg had no relationship. The 2-year PFS of 72% (95%CI:51-94) in children was higher than the 56% (95%CI:45-66) in adults despite their greater incidence of severe aGVHD. We conclude that aGVHD after DCBT is common, predominantly affects the gut, has a high treatment response, children are at a higher risk for severe disease, and late GVHD frequently has acute features. While survival is promising, improved prophylaxis and treatment are needed. A possible approach to reduce aGVHD in pediatric DCBT recipients with adequate CB unit doses would be to prioritize high resolution HLA-match. Moreover, our data does not currently support an upper limit of infused TNC/kg in DCBT recipients. Further investigation of the biology underlying these unique observations should be a priority.TableMultivariate AnalysisCharacteristicCumulative Incidence (95% CI)Hazard RatioP ValueAge (years)0-15 (n = 18)41% (17-65)2.6 (1.0-6.4)0.042≥ 16 (n = 90)20% (12 -29)Reference-Engrafting Unit-Recipient 10 Allele HLA-Match2-7/10 (n = 83)27% (17-37)Reference-8-9/10 (n = 25)12% (0-25)0.3 (0.1-1.0)0.053Unit-Unit 10 Allele HLA-Match0-5/10 (n = 59)20% (9-29)Reference-6-10/10 (n = 49)29% (16-42)2.2 (1.0-5.0)0.062Total TNC x107/kg< 5.0 (n = 68)20% (10-29)Reference-≥ 5.0 (n = 40)31% (16-46)1.2 (0.5-2.8)0.617 Open table in a new tab
Jubilee Point Development - Project Initiation (1986)

A description is presented of the initiation of a complex marina, residential and commercial development on Gulf St Vincent at the mouth of the Patawalonga Creek at Glenelg, near Adelaide, South Australia. The project initiation phase of the proposed development involved pre-feasibility studies and concept plans by engineers, architects, urban and environmental planners, and the preparation and public exhibition of a Draft Environmental Impact Statement. The end point of these investigations and report will be the concluding of an Indenture with the South Australian Government.
Differential Infrared Optical Mammography (2007)

A differential optical mammography technique is discussed. The imaging modality uses infrared trans-illumination to image breast tissue. Preliminary imaging data demonstrate potential use in screening for breast cancer.
ChemInform Abstract: Synthesis of Artificially Bent Oligonucleotides by Incorporation of Conformationally Rigid 5′‐Cyclouridylic Acid Derivatives (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Clinical, histologic, and ultrastructural changes after use of human growth factor and cytokine skin cream for the treatment of skin rejuvenation (2008)

The present study reports the clinical, histologic, and ultrastructural changes observed after the 6-month application of a novel skin cream containing a mixture of human growth factors and cytokines. Participants were asked to apply the human growth factor and cytokine skin cream twice daily to their entire face over a period of 6 months. A 3-mm punch biopsy was taken from the preauricular skin area before and after the treatment period. Further evaluations included photographic and clinical assessment of facial skin for wrinkles. After the treatment period, improved clinical appearance of periorbital and perioral wrinkles by 33% and 25% on average, respectively, was demonstrated. Histologic evaluation indicated moderate changes in the epidermal thickness as well as an increased fibroblast density in the superficial dermis at the end of the 6-month treatment period. Ultrastructural changes consistent with new collagen formation were shown by electron microscopy. This study, together with earlier studies, corroborates that topical application of growth factors and cytokines are beneficial in reducing signs of facial skin aging.
Nematodes Damaging Corn This Year (2010)

Currently, there is considerable interest and continued discussion among growers, agronomists and university researchers about plant-parasitic nematodes that feed on corn. To find out if these microscopic worms are damaging a corn crop, soil and roots must be collected and sent to a qualified laboratory to determine which specific nematodes are present and at what population densities (numbers).
Analysis of Soil Saturation Characteristics According to the Presence or Absence of Soil Layer Depth and Impervious (2013)

최근 많은 연구를 통해 비탈면의 우기시 안정성 검토 방법이 기존의 해석 방법에 비해 강우를 고려한 침투해석이 보다 경제적이고, 현실적이라는 주장이 제기되고 있다. 최근 개정된 건설공사 비탈면 설계기준에서도 보다 현실적인 안정성 검토를 위해우기 시 강우를 고려하여 침투해석을 실시할 수도 있게 개정되었다. 그러나 침투해석 과정에는 지반의 불투수특성과 강우강도등 고려되는 인자들로 인해 그 과정이 복잡하다는 애로사항이 있다. 본 연구에서는 침투해석을 이용한 보다 효과적인 안정성 검토 방법을 제시하기 위해 흙의 종류와 지속강우 특성에 따른 침투 조건을 변화시켜 일반적인 침투양상을 파악하였다. 그 결과를 이용하여 지표면까지 포화된다는 가정하에 해석을 실시할 수 있는 조건을 제시할 수 있었다. In recent study, infiltration analysis considering rainfall intensity is more economical and practical than existing analysis method. Revised construction slope design standard is also stated to full-fill infiltration analysis considering rainfall for practical stability review. Infiltration analysis considering rainfall for practical stability review. But, to infiltration analysis, the process is complicated by ground impermeability and rainfall intensity. In this study, we perform infiltration analysis to charge infiltration conditions, soil type and rainfall characteristics, for more pratical stability review. Using the result, we can suggest construable condition on the assumption that soil is saturated up to surface zone.
Impedimetric phosphorene field-effect transistors for rapid detection of lead ions (2018)

Stimuli-responsive field-effect transistors (FETs) based on 2D nanomaterials have been considered as attractive candidates for sensing applications due to their rapid response, high sensitivity, and real-time monitoring capabilities. Here we report on an impedance spectroscopy technique for FET sensor applications with ultra-high sensitivity and good reproducibility. An alumina-gated FET, using an ultra-thin black phosphorus flake as the channel material, shows significantly improved stability and ultra-high sensitivity to lead ions in water. In addition, the phase angle in the low frequency region was found to change significantly in the presence of lead ion solutions, whereas it was almost unchanged in the high frequency region. The dominant sensing performance was found at low frequency phase spectrum around 50 Hz and a systematic change in the phase angle in different lead ion concentrations was found. Applying the impedance spectroscopy technique to insulator-gated FET sensors could open a new avenue for real-world sensor applications.
ChemInform Abstract: Analysing and Understanding the Active Site by IR Spectroscopy (2011)

Abstract Review: 138 refs.
Incidence and Prognostic Significance of Depressive Symptoms in Peripheral Artery Disease (2016)

People with PAD have a higher incidence of depressive symptoms than people without PAD. In PAD, depressive symptoms are associated with increased all-cause and cardiovascular mortality. These associations are explained in part by poorer 6-minute walk among people with PAD and among depressed people with PAD, respectively.
Field emission characterization of the 10×10 singly-addressable double-gated polysilicon tip array (2002)

A conventional field-emission cell, which usually consists of an emission tip surrounded by a small aperture in an extracting electrode (grid), has very complicated electron-optical characteristics. Electron beam trajectories are influenced not only by the electric field formed between the emission tip and the gate, but also by the field in the proximity of the emission site. This problem can be effectively resolved by controlling the shape of the individual electron beams.
Periodic Solutions and Stability of a Nonlinear Flexible Slider Crank Mechanism by Hbm/Fft (1995)

Abstract Periodic steady state solutions are generated by the Harmonic Balance/Fast Fourier Transform method from the nonlinear differential equation of an Euler‐Bernoulli beam rod, constant speed crank, slider crank mechanism. Stability and response of those solutions are examined when piston mass and crank length are varied. Jump, period doubling bifurcations, and amplified response were found.