gebhart/patrepeval huggingface dataset:
Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner (2011)

Protection against infection with Mycobacterium tuberculosis demands IFN-γ. SOCS1 has been shown to inhibit responses to IFN-γ and might thereby play a central role in the outcome of infection. We found that M. tuberculosis is a highly efficient stimulator of SOCS1 expression in murine and human macrophages and in tissues from infected mice. Surprisingly, SOCS1 reduced responses to IL-12, resulting in an impaired IFN-γ secretion by macrophages that in turn accounted for a deteriorated intracellular mycobacterial control. Despite SOCS1 expression, mycobacteria-infected macrophages responded to exogenously added IFN-γ. SOCS1 attenuated the expression of the majority of genes modulated by M. tuberculosis infection of macrophages. Using a conditional knockdown strategy in mice, we found that SOCS1 expression by macrophages hampered M. tuberculosis clearance early after infection in vivo in an IFN-γ-dependent manner. On the other hand, at later time points, SOCS1 expression by non-macrophage cells protected the host from infection-induced detrimental inflammation.
Multiscale Modelling and Simulation of Nanoparticle-reinforced Damping Materials (2006)

Carbon nanotubes are used in many applications, particularly for vibration damping and noise reducing materials. In the present paper, multiscale computational approaches to modeling of nanoparticle-reinforced composite materials and virtual reality engineering tools have been used to describe/model an intuitive interface of some CNTreinforced materials to enable efficient design and synthesis of next generation materials and nanoscale devices. The scope is to understand the damping mechanisms in a viscoelastic polymeric medium. In this paper the equilibrium equation of damping structure is described with advanced FEM-based models and is solved with the help of a numerical code created by CASE tools.
Systems Durability of a Ceramic Racetrack Converter (1991)

&lt;div class="htmlview paragraph"&gt;The long-term durability of a ceramic racetrack converter is examined using the systems approach. Each of the converter components is characterized with respect to its behavior under simulated mechanical and thermal loads. In particular, the impact of three different washcoats on key physical properties, and the load vs. deformation characteristics of three different insulation mats are examined from mechanical and thermal durability point of view. Similarly, the can deformation at elevated temperature is taken into account to ensure adequate mounting pressure on ceramic monolith under all operating conditions.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The temperature distribution at the midbed of the catalyst during engine dynamometer testing, together with the component properties data, are then used in a finite element model to compute thermal stresses in the monolith as function of engine load and speed. The combined stresses in the monolith (including the effect of radial pressure from the mat) are compared with its high temperature strength and the probability of stress corrosion over the lifetime of the converter is examined using thermal fatigue data for the monolith. In this manner, the engine conditions and converter designs which limit the operating stresses to less than 50% of monolith strength are identified to ensure failure-free operation of the racetrack converter system.&lt;/div&gt;
Demonstration of Single-Photon Three-Qubit Quantum Logic with Spatial Light Modulators (2014)

We experimentally demonstrate linear, deterministic, single-photon three-qubit quantum gates implemented by a polarization-sensitive spatial light modulator and using polarization and spatial-parity qubits. We also prepare single-photon three-qubit GHZ and W states and present tomographic measurements.
Informational skills of teachers and students of Secondary Obligatory Education (2017)

The teaching professional must have the competence to know how to manage new knowledge because it is the raw material in its stage performance. Schools are a factory of knowledge that must be current. Moreover, there is also the need for the student to acquire this capacity, and therefore, the teacher as a transmitter of knowledge, and skills can promote this fact. The research aims to learn the skills to manage information, and socialize knowledge. For this purpose two instruments used; a quantitative (questionnaire) and a qualitative (interview). In this way, we can objectify, contrast and deeper into the reality where we stand.Through the application of quantitative and qualitative instruments and the subsequent analysis of the data, we get to know the reality of educational practice regarding the assessment of information skills of teachers and students. Complementary to current teaching and learning processes for the development of competition studied is analyzed. In order to obtain a better analysis has been carried segmentation in three dimensions; search, processing and communication of information on the line of self-conceptualization of joint information competence
Optical Properties of Tetrahedral Quantum Dot Quantum Wells (2005)

Taking into account the tetrahedral shape of a quantum dot quantum well (QDQW) when describing excitonic states, phonon modes and the exciton‐phonon interaction in the structure, we obtain a quantitative interpretation of the photoluminescence (PL) spectrum of a single CdS/HgS/CdS QDQW within a non‐adiabatic approach. A remarkable effect of the QDQW’s shape is that the exciton in the ground state is bright for the tetrahedral QDQW, while it is dark for the spherical QDQW.
Dissimilar phorbol ester binding properties of the individual cysteine‐rich motifs of protein kinase D (1998)

Protein kinase D (PKD) is a serine/threonine kinase that binds phorbol esters in a phospholipid-dependent manner via a tandemly repeated cysteine-rich, zinc finger-like motif (the cysteine-rich domain, CRD). Here, we examined whether the individual cysteine-rich motifs of the CRD of PKD (referred to as cysl and cys2) are functionally equivalent in mediating phorbol ester binding both in vivo and in vitro. Our results demonstrate that the cysl and cys2 motifs of the CRD of PKD are functionally dissimilar, with the cys2 motif responsible for the majority of [3H]phorbol 12,13-dibutyrate (PDB) binding, both in vivo and in vitro.
Emotions as Proximal Causes of Word of Mouth: A Nonlinear Approach. (2018)

Service research tends to operationalize word of mouth (WOM) behavior as one of the many responses to service satisfaction. In this sense, little is known about its antecedents or moderators. The objective of this study was to investigate the role of customers' emotions during service experiences on WOM, applying nonlinear techniques and exploring the moderating role of customers' propensity for emotional contagion. Using the critical incidents technique, 122 customers recalled significant service experiences and the emotions they aroused, and reported if they shared said experiences with other individuals. We found that, whereas linear methods presented non-significant results in the emotions-WOM relationship, nonlinear ones (artificial neural networks) explained 46% of variance. Negative emotions were stronger predictors of WOM and the importance of emotions for WOM was significantly higher for individuals with high propensity for emotional contagion (R^2 = .79) than for those with lower levels (R^2 = .48). Theoretical and practical implications are discussed.
Performance Characteristics of Elbow Flowmeters (1964)

The state of the art for metering flow with elbow meters is surveyed and past work is correlated with recent data from tests at the Naval Boiler and Turbine Laboratory. The elbow meter is compared with the orifice, Venturi, and flow nozzle and areas where research is needed are delineated.
Visualisierung zentral-auditiver Prozesse mit funktioneller Magnetresonanztomographie* (1998)

The overlap of the different frequencies could explain the controversial discussion of the tonotopic organization of the auditory cortex. The results of the monaural acoustic stimulation show clearly the predominant signal increase of contralateral areas in the primary auditory cortex. These results confirm the opinion of the current textbooks that the fiber of the auditory pathways mostly cross. Further investigations using functional MRI are necessary for better understanding of physiological and pathophysiological central-auditory processes.
Attenuation of hydrogen radicals traveling under flowing gas conditions through tubes of different materials (2006)

Hydrogen radical concentrations traveling under flowing gas conditions through tubes of different materials were measured using a dual thermocouple probe. The source of the hydrogen radicals was a toroidal radio frequency plasma source operating at 2.0 and 3.3kW for H2 pressures of 250 and 500mTorr, respectively. The dual thermocouple probe was comprised of exposed and covered Pt∕Pt13%Rh thermocouples. Hydrogen radicals recombined efficiently on the exposed thermocouple and the energy of formation of H2 heated the thermocouple. The second thermocouple was covered by glass and was heated primarily by the ambient gas. The dual thermocouple probe was translated and measured temperatures at different distances from the hydrogen radical source. These temperature measurements were conducted at H2 flow rates of 35 and 75SCCM (SCCM denotes cubic centimeter per minute at STP) inside cylindrical tubes made of stainless steel, aluminum, quartz, and Pyrex. The hydrogen radical concentrations were obtained from the temperatures of the exposed and covered thermocouples. The hydrogen concentration decreased versus distance from the plasma source. After correcting for the H2 gas flow using a reference frame transformation, the hydrogen radical concentration profiles yielded the atomic hydrogen recombination coefficient, γ, for the four materials. The methodology of measuring the hydrogen radical concentrations, the analysis of the results under flowing gas conditions, and the determination of the atomic hydrogen recombination coefficients for various materials will help facilitate the use of hydrogen radicals for thin film growth processes.
<title>Fast algorithms for automatic moire fringe analysis: application to noncontact measurements for quality control of industrial components</title> (1996)

Moire methods are optical methods that are based on the effect of superposition of grating lines and have been widely used in the context of industrial applications for shape analysis, for non-contact measurements, and for quality control of industrial components. In applications the following computations: image filtering, fringe skeletonizing and fringe numbering have to be performed for each test object, before comparison between the numerically reconstructed test object shape and its CAD model. In order to reduce the computing time required by the preceding computations, the inverse moire technique has been introduced by Harthong. Instead of using a grating made of parallel straight lines, the inverse moire technique uses a pre-computed specific gratin, that is formed of curved lines such that the moire pattern is composed of parallel straight fringes if the test object shape is conformed to its CAD model. Defects are then characterized by a deformation and a curvature of these parallel fringes. In this paper, we present examples showing that standard fringe extraction by automatic thresholding is not that easy. To overcome this difficulty, we propose a four stage process algorithmical approach that allows fringe detection in inverse moire images with high sensitivity and specificity. First we used the well-known image processing technique called unsharp masking, to enhance moire image and to emphasize low contrasted fringes. The second step is to extract bright fringes by image segmentation and constrained contour modeling. After detection of these bright fringes inside the zone of interest of the moire image, we get the thick skeleton of adjacent background and of dark fringes. The third step is to skeletonize this thick skeleton of adjacent background and of dark fringes, using morphological thinning of well-composed sets, that assures that each fringe skeleton will be one pixel thick, at the difference of standard thinning techniques. The fourth step is to apply a graph technique to isolate the individual dark fringes. When all these four steps have been followed, one is left with a binary image showing the dark fringe pattern skeleton. The experimental results that have been obtained have shown the robustness of this algorithmical approach, for the analysis of noisy inverse moire images.
Coloquinte. Marzouk (B), Boukef (M. K.), Marzouk (Z.), «Citrullus Colocynthis Schrad», Essaydali, juin 2012, 123, p. 44-54 (2012)

Bonnemain Bruno. Coloquinte. Marzouk (B), Boukef (M. K.), Marzouk (Z.), «Citrullus Colocynthis Schrad», Essaydali, juin 2012, 123, p. 44-54. In: Revue d'histoire de la pharmacie, 99e année, N. 376, 2012. pp. 540-541.
Regio- and stereoselective modification of cytosine with cyanopropargylic alcohols (2017)

Cyanopropargylic alcohols (4-hydroxyalk-2-ynenitriles) add cytosine at the triple bond under mild conditions (3–5 mol% K2CO3, DMF, 20–25 °C, 2–3 h) to afford regio- and stereoselectively the Michael adducts, (Z)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-4-hydroxy-4-alkylalk-2-enenitriles, in80–88% yield.
α-Adducin dissociates from F-actin and spectrin during platelet activation (2003)

Aspectrin-based skeleton uniformly underlies and supports the plasma membrane of the resting platelet, but remodels and centralizes in the activated platelet. alpha-Adducin, a phosphoprotein that forms a ternary complex with F-actin and spectrin, is dephosphorylated and mostly bound to spectrin in the membrane skeleton of the resting platelet at sites where actin filaments attach to the ends of spectrin molecules. Platelets activated through protease-activated receptor 1, FcgammaRIIA, or by treatment with PMA phosphorylate adducin at Ser726. Phosphoadducin releases from the membrane skeleton concomitant with its dissociation from spectrin and actin. Inhibition of PKC blunts adducin phosphorylation and release from spectrin and actin, preventing the centralization of spectrin that normally follows cell activation. We conclude that adducin targets actin filament ends to spectrin to complete the assembly of the resting membrane skeleton. Dissociation of phosphoadducin releases spectrin from actin, facilitating centralization of spectrin, and leads to the exposure of barbed actin filament ends that may then participate in converting the resting platelet's disc shape into its active form.
Evaluation of chicken embryo chorioallantoic membrane model for laryngeal squamous cell carcinoma transplantation (2013)

Introduction. Nummerous experimental models have been used to study the morphology of malignant tumours. Chicken chorioallantoic membrane (CAM) is an appropriate and well established model to study the behaviour of different tumours, laryngeal as well. The aim: to evaluate the morphological changes of chicken CAM with laryngeal squamous cell carcinoma (LSCC) tissues onplants. Methods. LSCC tissue samples were ontained from the operated patients, carried immediately too the laboratory in isotonic saline solution and transplanted onto chicken CAM in the period of 168 to 216 hours of the egg incubation. After 72 hours of incubation on CAM, the transplants were removed with the CAM. Histological slides were evaluated histologically, and morphometric determination of changes in CAM and chorionic epithelium thickness was performed. Results. 5 LSCC were grafted on the chicken CAM (n=17). The transferred carcinoma tissue samples on the CAM never flowed away and firmly adhered to the membrane. The CAM under the onplanted carcinoma tissue was thickened due to the thickening of the chorionic epithelium and the mesenchymal layer under it. Thickness of the CAM under LSCC was 103.8±83 μm, controls 85.78±85 μm. Thickness of the epithelium under LSCC 11.38±4 μm, controls 5.14±0.1 μm (p=0.000). The CAM and the epithelium under the grafted carcinoma tissue, neighbouring sites and distant sites of CAM were statistically thickened in comparison to control group. The mean value of the CAM thichness did not differ in the 5 grafted tumour groups. Conclusions. LSCC tumours can survive on CAM and have the influence on CAM itself causing thickening of chrionic epithelium and mesenchymal layer under it and of CAM itself.
Mobile phone use and willingness to pay for SMS for diabetes in Bangladesh (2015)

The high proportion of mobile phone use and WTP for diabetes SMS are encouraging as possible strategy to use such technologies and deserve further evaluation.
SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications (2020)

The myelodysplastic syndromes (MDS) are common myeloid malignancies characterized by ineffective hematopoiesis and blood cytopenias, with patients showing increasing bone marrow blasts with disease progression Mutations in genes involved in pre-mRNA splicing (SF3B1, SRSF2, U2AF1, and ZRSR2) are the most common mutations found in MDS, occurring in over 50% of all cases [2-4]. There is evidence that some spliceosome components play a role in the maintenance of genomic stability Splicing is a transcription coupled process; splicing factor mutations affect transcription and may lead to the accumulation of Rloops (RNA-DNA hybrids with a displaced single stranded DNA) Mutations in the splicing factors SRSF2 and U2AF1 have been recently shown to increase R-loop formation in leukemia cell lines, resulting in increased DNA damage, replication stress, and activation of the ATR-Chk1 pathway SF3B1 is the most frequently mutated
Phase 3 Trial of mRNA-1273 during the Delta-Variant Surge (2021)

mRNA-1273 Vaccine Efficacy against the Delta Variant Participants who had received placebo in a previous phase of this trial were offered the mRNA-1273 vaccine in the open-label phase. The incidenc...
Amino Acids as Complexing Agents in Chemical−Mechanical Planarization of Copper (2005)

This study explains the relative importance of the *OH radical in the presence of other additives in hydrogen peroxide based slurries during chemical−mechanical planarization of copper. For this purpose, we investigated the effects of three different amino acids, that is, glycine, serine, and cysteine, in the presence of H2O2 on the dissolution of copper coupons and on the polishing of copper disks with well-dispersed slurries of fumed silica particles over the pH range 2.0 and 8.0. While these amino acids produced different amounts of *OH, the polish rates did not depend on the concentration of this radical alone but were influenced by other parameters such as the pH of the slurries and the specific interactions of the amino acids with other components of the slurry.
A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis (2008)

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK) against Leishmania major challenge in mice, which was consistent with results from TRYP protein/adjuvant combinations in non-human primates. This study aimed to conduct safety and immunogenicity trials of these DNA/MVA vaccines in dogs, the natural reservoir host of Leishmania infantum, followed-up for 4 months post-vaccination. In a cohort of 22 uninfected outbred dogs, blinded randomised administration of 1000 microg (high dose) or 100 microg (low dose) DNA prime (day 0) and 1x10(8)pfu MVA boost (day 28) was shown to be safe and showed no clinical side effects. High dose DNA/MVA vaccinated TRYP dogs produced statistically higher mean levels of the type-1 pro-inflammatory cytokine IFN-gamma than controls in whole blood assays (WBA) stimulated with the recombinant vaccine antigen TRYP, up to the final sampling at day 126, and in the absence of challenge with Leishmania. TRYP vaccinated dogs also demonstrated significantly higher TRYP-specific total IgG and IgG2 subtype titres than in controls, and positive in vivo intradermal reactions at day 156 in the absence of natural infection, observed in 6/8 TRYP vaccinated dogs. No significant increases in IFN-gamma in LACK-stimulated WBA, or in LACK-specific IgG levels, were detected in LACK vaccinated dogs compared to controls, and only 2/9 LACK vaccinated dogs demonstrated DTH responses at day 156. In all groups, IgG1 subclass responses and antigen-specific stimulation of IL-10 were similar to controls demonstrating an absence of Th2/T(reg) response, as expected in the absence of in vivo restimulation or natural/experimental challenge with Leishmania. These collective results indicate significant antigen-specific type-1 responses and in vivo memory phase cellular immune responses, consistent with superior potential for protective vaccine immunogenicity of DNA/MVA TRYP over LACK.
Enhancement of Hepatocellular Proliferative Activity of Kojic Acid in Mice by a Simultaneous Administration of Ascorbic Acid (2007)

To examine the tumor modification activity of kojic acid (KA) by sodium ascorbic acid (AA), 5-week-old male ICR mice were administered intraperitoneally with N-diethylnitrosamine (DEN) as an initiation treatment. Two weeks after the initiation treatment, animals were fed basal diet containing 0 (Group 1: DEN alone) or 3% KA (Group 3: DEN+KA), drinking water containing 5,000 ppm AA (Group 2: DEN+AA) or 3% KA and 5,000 ppm AA (Group 4: DEN+KA+AA) for 6 weeks. One week after the administration of KA and/or AA, all mice were subjected to two-thirds partial hepatectomy. At the end of the experimental period, all surviving mice were sacrificed and removed the liver. The liver weights of the Groups 3 and 4 were significantly increased, and the number of proliferating cell nuclear antigen positive hepatocytes and the gene expressions of Ccnc, Ccnd1, Ercc and Cyp7a1 were significantly increased in the Group 4, as compared to the Group 1. These results of the present study suggest that AA enhances the hepatocellular proliferative activity of KA in mice.
Structural effects on the antitumour activity of a series of di(4‐substituted phenyl)tin dichloride complexes with nitrogen‐donor ligands (1989)

Abstract Investigation of the antitumour activity of a series of diorganotin dichloride complexes (4‐ZC 6 H 4 ) 2 SnCl 2 ·L 2 , where Z = OMe, Me, F, Cl, and CF 3 and L 2 = 2,2′‐bipyridyl (bipy), 1,10‐phenanthroline (phen) and 2‐aminomethylpyridine (amp) is reported. A number of these complexex are shown to exhibit reproducible activity in vivo towards P388 lymphocytic leukaemia in mice. 1 H NMR data are reported for an extended series of (4‐ZC 6 H 4 ) 4 Sn and the parent dichlorides (4‐ZC 6 H 4 ) 2 SnCl 2 of the above‐mentioned complexes. A correlation is reported between Hammett substituent constants and 1 H chemical shift data. Attempts are made to relate the antitumour activity of the complexes to various structural factors. The dependence of antitumour activity on the electronic effect of group Z and the nature of the ligand L 2 is demonstrated.
Analysis of intraocular lens surface properties with atomic force microscopy (2006)

Atomic force microscopy was effective and accurate in analyzing IOL optics. The surface topography of IOLs may vary with different manufacturing processes.