gebhart/patrepeval huggingface dataset:
Etude de l'implication de CD146/CD146 soluble dans l'angiogenèse et le développement tumoral : génération de nouveaux anticorps à visée thérapeutique (2017)

CD146 est une molecule d’adhesion appartenant a la superfamille des immunoglobulines qui existe sous trois formes, deux isoformes membranaires et une forme soluble. Elle a ete decouverte initialement dans les cellules de melanome humain ou son expression est un marqueur de mauvais pronostic. Depuis elle a ete decrite dans de nombreux types de cancer (prostate, sein, rein, poumon non a petites cellules, …). Elle est aussi exprimee sur l’ensemble de l’endothelium vasculaire.Dans la premiere partie de ce travail, nous avons montre que CD146 soluble provient du clivage de l’ectodomaine des isoformes longue et courte de CD146 respectivement par ADAM 10 et Tace (ADAM 17). De plus, nous avons identifie deux autres isoformes de CD146 soluble provenant d’un epissage alternatif, I10-sCD146 et I5-13-sCD146. Ces differentes formes de CD146 soluble agissent sur l’endothelium vasculaire en stimulant l’angiogenese.Dans la seconde partie du travail, nous avons genere un anticorps anti-CD146 capable de detecter CD146 dans les cellules cancereuses mais pas dans les cellules qui l’expriment dans les conditions physiologiques (cellules endotheliales, cellules musculaires lisses). Nous avons montre que cet anticorps presente un interet diagnostique et un interet therapeutique. Son mecanisme d’action implique une internalisation de la molecule CD146, ce qui permet d’envisager une utilisation en medecine personnalisee.
Death by Lethal Injection (1997)

Yersinia, the genus of bacteria that produced the Black Plague, has devised a specialized secretion mechanism that injects toxic protein into cells. Silhavy describes this type III secretion mechanism, including the new results presented on p.
 1140
 of this issue that identify the targeting signal for these proteins. Unlike the signal sequences of many conventionally secreted proteins, which are located within the protein, the targeting information for these secreted proteins actually lies within their messenger RNA.
Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children (2013)

The knowledge about correlation patterns between the fecal microbiota and inflammatory bowel diseases (IBD)-comprising the two subforms Crohn's disease (CD) and ulcerative colitis (UC)-for newly diagnosed untreated children is limited. To address this knowledge gap, a selection of faecal specimens (CD, n = 27 and UC, n = 16) and non-IBD controls (n = 30) children (age < 18 years) was analysed utilising bacterial small subunit (SSU) rRNA. We found, surprising age dependence for the fecal microbiota correlating to IBD. The most pronounced patterns were that E. coli was positively (R (2) = 0.16, P = 0.05) and Bacteroidetes, negatively (R (2) = 0.15, P = 0.05) correlated to age for CD patients. For UC, we found an apparent opposite age-related disease correlation for both Bacteroides and Escherichia. In addition, there was an overrepresentation of Haemophilus for the UC children. From our, results we propose a model where the aetiology of IBD is related to an on-going immunological development in children requiring different age-dependent bacterial stimuli. The impact of our findings could be a better age stratification for understanding and treating IBD in children.
Cardiac Arrhythmias Imprint Specific Signatures on Lorenz Plots (2008)

Major tachyarrhythmias imprint specific patterns on two-dimensional Lorenz plots generated from 24-hour Holter recordings. Thus, the Lorenz plot method has the potential to significantly improve the accuracy of arrhythmia detection and differentiation, particularly with respect to supraventricular tachyarrhythmias.
Ionic polymer metal composites with polypyrrole-silver electrodes (2015)

Ionic polymer metal composites (IPMCs) are a class of soft active materials that are finding increasing application in robotics, environmental sensing, and energy harvesting. In this letter, we demonstrate the fabrication of IPMCs via in-situ photoinduced polymerization of polypyrrole-silver electrodes on an ionomeric membrane. The composition, morphology, and sheet resistance of the electrodes are extensively characterized through a range of experimental techniques. We experimentally investigate IPMC electrochemistry through electrochemical impedance spectroscopy, and we propose a modified Randle's model to interpret the impedance spectrum. Finally, we demonstrate in-air dynamic actuation and sensing and assess IPMC performance against more established fabrication methods. Given the simplicity of the process and the short time required for the formation of the electrodes, we envision the application of our technique in the development of a rapid prototyping technology for IPMCs.
Concurrent Reading While Writing (1983)

article Free Access Share on Concurrent Reading While Writing Author: Gary L. Peterson Department of Computer Science, The University of Rochester, Rochester, NY Department of Computer Science, The University of Rochester, Rochester, NYView Profile Authors Info & Claims ACM Transactions on Programming Languages and SystemsVolume 5Issue 1Jan. 1983 pp 46–55https://doi.org/10.1145/357195.357198Published:01 January 1983Publication History 130citation1,109DownloadsMetricsTotal Citations130Total Downloads1,109Last 12 Months118Last 6 weeks18 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A Matchmaking-based Ontology Evolution Methodology. (2006)

Abstract. In this paper, we present the H-Change methodology we have specifically conceived for evolving independent ontologies in open networked systems. Furthermore, we describe the change detection techniques based on semantic matchmaking for determining the most appropriate location where to frame new incoming knowledge within an existing ontology. Change assimilation techniques for evolving ontology metadata to incorporate the new incoming knowledge at different integration levels are also outlined. 1
Tip timing measurement chain validation with the Universal Tip Timing Calibrator UTTC, approach and experience (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Uwe Pfeifer, Michael Zidorn; Tip timing measurement chain validation with the Universal Tip Timing Calibrator UTTC, approach and experience. AIP Conf. Proc. 13 June 2012; 1457 (1): 43–51. https://doi.org/10.1063/1.4730541 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
In-situ height correction for laser scanning of semiconductor wafers (1995)

An <i>in situ</i> technique for servo control of surface height during laser scanning of semiconductor wafers is described. The scheme corrects any macroscopic height changes due to tilt and bow in the wafer and rejects local and pattern-dependent changes of height and reflectivity. The waist of the scanning beam is imaged on a slit aperture placed in front of a position-sensitive photodiode, leading to an ac signal at the scanning frequency. This ac signal then undergoes synchronous detection using a reference signal at the scanning frequency. This detection scheme leads to a reduced sensitivity to low-frequency electronic and thermal drifts. Normalization circuitry provides means for excluding the effects of reflectivity which can vary over four orders of magnitude on patterned wafers. The height signal, so obtained, is used to drive a PZT stage to a nominal height position in closed loop. On patterned wafers, an rms height accuracy of better than 0.1 μm has been achieved in 20-Hz bandwidth.
Absolute measurement of dielectronic recombination forC3+in a known external field (1996)

An absolute measurement of the rate coefficient for dielectronic recombination (DR) of ${\mathrm{C}}^{3+}$, via the 2s-2p core excitation, in an external electric field of 11.4\ifmmode\pm\else\textpm\fi{}0.9(1\ensuremath{\sigma}) V ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ is presented. An inclined-beam arrangement is used and the stabilizing photons at \ensuremath{\sim}155 nm are detected in delayed coincidence with the recombined ions. The full width at half maximum of the electron energy spread in the ion rest frame is 1.74\ifmmode\pm\else\textpm\fi{}0.22(1\ensuremath{\sigma}) eV. The measured DR rate, at a mean electron energy of 8.26\ifmmode\pm\else\textpm\fi{}0.07(1\ensuremath{\sigma}) eV, is (2.76\ifmmode\pm\else\textpm\fi{}0.75)\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}10}$ ${\mathrm{cm}}^{3}$ ${\mathrm{s}}^{\mathrm{\ensuremath{-}}1}$. The uncertainty quoted for the DR rate is the total uncertainty, systematic and statistical, at the 1\ensuremath{\sigma} level. In comparing the present results to theory, a semiempirical formula is used to determine which recombined ion states are ionized by the 4.65 kV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ fields in the final-charge-state analyzer and not detected. For the present results, any DR of the incident electrons into n levels greater than 44 is assumed to be field ionized in the final-charge-state analyzer. A more precise treatment of field ionization, which includes the lifetime of the ${\mathrm{C}}^{2+}$ ions before they are ionized and the time evolution and rotation of the fields experienced by the recombined ions, is needed before a definitive comparison between experiment and theory can be made. Our DR measurement, within the limits of that approach, agrees reasonably well with an intermediate coupling calculation that uses an isolated resonance, single-configuration approximation, but does not agree with pure LS-coupling calculations. \textcopyright{} 1996 The American Physical Society.
Radial Velocities with Gaia (2004)

Gaia is a mission to map the positions and determine the velocities of 1 billion stars in the Galaxy, in order to determine how it was formed and how it has evolved. Spectroscopy provides one component of the space velocities for 200 million objects, and, in addition, astrophysical information such as temperature and metallicity for the brighter 40 million stars in a large unbiased Galactic sample. Together the instruments on Gaia will transform our knowledge of the Galaxy. We describe here a sample of the science that will be done with Gaia concentrating on aspects in which the spectroscopy plays a central role.
Achievement of 1 MHz frequency stability of semiconductor lasers by double-loop AFC scheme (1981)

A temperature-controlling AFC system has been developed to realise high-frequency stability with semiconductor lasers. The frequency drift in DC operation can be reduced to below 1 MHz peak-to-peak. When necessary, the laser frequency can be modulated directly in the AFC state while the centre frequency is kept stabilised within 3 MHz. A heterodyne experiment was also performed using two frequency stabilised lasers; a stable IF output could be obtained for 10 min.
Stimulatory effect of ouabain on T- and L-type calcium currents in guinea pig cardiac myocytes (1990)

The effect of 10(-6) M ouabain on macroscopic low-threshold T-type Ca2+ and high-threshold L-type Ca2+ currents was studied by whole cell recording in isolated guinea pig ventricular myocytes superfused with K-free, Na-free media, i.e., after suppression of Na-K-ATPase activity and Na influx through the Na-Ca exchanger. Under such conditions, the amplitudes of the two currents were significantly increased by ouabain. In particular, the current occurring in the -50 to -20 mV range (T-type Ca2+) was increased two- to threefold by ouabain and suppressed by 40 microM Ni2+. Ouabain shifted by approximately 10 mV toward negative potentials the steady-state inactivation curve of the T-type Ca2+ current but not that of the L-type Ca2+ current. It is concluded that ouabain enhances not only L-type Ca2+ current but also T-type Ca2+ current possibly through different mechanisms.
Limit Analysis of Ice Sheet Indentation (1983)

The methods of plastic limit analysis are used to determine the indentation pressures of a flat rectangular punch on an ice sheet. The ice sheet is idealized as a semi-infinite layer of elastic-perfectly plastic material. Lower bounds are computed by application of the lower bound limit theorem. The suitability of basic yield functions are assessed based on their ability to predict failure at demonstrated ice failure stress ratios. The particular yield functions that are employed include the generalized Mohr-Coulomb (or Drucker-Prager) criterion, a modified Drucker-Prager criterion, as well as a parabolic yield criterion used previously in literature on this topic. A study of the effects on indentation pressure of varying ice strength parameters is presented. Limit analysis solutions are obtained for plane stress conditions, and thus the applicability of a particular yield function can be evaluated for a range of ice strengths for indentation problems involving high aspect ratios.
Power broadening in a He-Ne laser (1968)

Considerable power broadening of Ne <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2p_{4}</tex> saturation peaks in a 0.63-μ He-Ne laser is observed by tuned laser differential spectrometry. The results are in agreement with calculations that properly distinguish broadening and quenching collisions.
Source-Specific Multicast for IP (2006)

IP version 4 (IPv4) addresses in the 232/8 (232.0.0.0 to 232.255.255.255) range are designated as source-specific multicast (SSM) destination addresses and are reserved for use by sourcespecific applications and protocols. For IP version 6 (IPv6), the address prefix FF3x::/32 is reserved for source-specific multicast use. This document defines an extension to the Internet network service that applies to datagrams sent to SSM addresses and defines the host and router requirements to support this extension.
Photocurrent Generation and Polarity Switching in Electrochemical Cells through Light‐induced Excited State Proton Transfer of Photoacids and Photobases** (2023)

Light is a common source of energy in sustainable technologies for photocurrent generation. To date, in such light-harvesting applications, the excited electrons generate the photocurrent. Here, we introduce a new mechanism for photocurrent generation that is based on excited state proton transfer (ESPT) of photoacids and photobases that can donate or accept a proton, respectively, but only after excitation. We show that the formed ions following ESPT can either serve as electron donors or acceptors with the electrodes, or modify the kinetics of mass transport across the diffuse layer, both resulting in photocurrent generation. We further show that control of the current polarity is obtained by switching the irradiation between the photoacid and the photobase. Our study represents a new approach in photoelectrochemistry by introducing ESPT processes, which can be further utilized in light-responsive energy production or energy storage.
Characterization of piRNAs across postnatal development in mouse brain (2016)

PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
SiV yield optimization via counted ion implantation. (2016)

Abstract not provided.
Correlation between Particle Motion and Voronoi-Cell-Shape Fluctuations during the Compaction of Granular Matter (2008)

We track particle motions in a granular material subjected to compaction using a laser scattering-based imaging method where compaction is achieved through thermal cycling. Particle displacements in this jammed fluid correlate strongly with rearrangements of the Voronoi cells defining the local environment about the particles, similar to previous observations of Rahman on cooled liquids. Our observations provide further evidence of commonalities between particle dynamics in granular matter close to jamming and supercooled liquids.
FeNi intermetallic compound nanoparticles wrapped with N-doped graphitized carbon: a novel cocatalyst for boosting photocatalytic hydrogen evolution (2020)

FeNi intermetallic compound nanoparticles wrapped by N-doped graphitized carbon is used as a novel cocatalyst for boosting photocatalytic hydrogen evolution performance of g-C<sub>3</sub>N<sub>4</sub>.
C-Glycosyl Amino-Substituted Hydro- and Benzoquinones: Synthesis and Preliminary Biological Evaluation (2007)

Reaction of C-β-d-glycopyranosyl-1,4-dimethoxybenzenes with acetyl nitrate afforded 2-(β-d-glycopyranosyl)-1,4-dimethoxy-5-nitrobenzenes in high yields. These were converted smoothly (reduction to amines, N-acylation, oxidation, and reduction) into the corresponding C-glycosyl-hydro(benzo)quinone derivatives, with different amide-based substituents at C-5. Reduction of the nitro compounds to amines proceeded smoothly by catalytic hydrogen transfer with HCO2NH4.
A novel provisioning framework for dual-node interconnected SONET/SDH rings (2006)

We present a new approach to provision connections in a network of dual-node interconnected rings. Our approach satisfies the unique constraints imposed by SONET/SDH standards and is very useful for reducing link capacity fragmentation.
Hypothalamus and Gastric Ulceration (1962)

<h3>Introduction</h3> It has been demonstrated in Part I of this communication that discrete hypothalamic destruction consistently results in acute gastrointestinal erosion. It seemed reasonable, therefore, to postulate that chronic stimulation in this area might also result in acute and possibly chronic ulceration. This study was undertaken to investigate this hypothesis. <h3>Technique</h3> Thirty healthy male and female cats weighing from 2.4 to 4.9 kg. were utilized in this study. Details of care of animals and operative procedures have been reported in Part I of this communication. The technique of electrode manufacture and placement will be presented. Electrodes were concentric in type, made of No. 32 Beldenamel wire (Belden Mfg. Co.), inserted through a 26-gauge stainless steel tubing. The tip of this wire was allowed to protrude 0.5 mm. beyond the tubing. The opposite end of the wire served as one terminal, while a second piece of No. 32 Beldenamel wire was
Emerging treatment paradigms with FLT3 inhibitors in acute myeloid leukemia (2019)

Mutations in the fms-like tyrosine kinase 3 (<i>FLT3</i>) gene are detected in approximately one-third of patients with newly diagnosed acute myeloid leukemia (AML). These consist of the more common <i>FLT3</i>-internal tandem duplication (ITD) in approximately 20-25% of AML cases, and point mutations in the tyrosine kinase domain (TKD) in approximately 5-10%. <i>FLT3</i> mutations, especially <i>FLT3</i>-ITD, are associated with proliferative disease, increased risk of relapse, and inferior overall survival when treated with conventional regimens. However, the recent development of well tolerated and active FLT3 inhibitors has significantly improved the outcomes of this aggressive subtype of AML. The multikinase inhibitor midostaurin was approved by the United States Food and Drug Administration (US FDA) in April 2017 for the frontline treatment of patients with <i>FLT3</i>-mutated (either ITD or TKD) AML in combination with induction chemotherapy, representing the first new drug approval in AML in nearly two decades. In November 2018, the US FDA also approved the second-generation FLT3 inhibitor gilteritinib as a single agent for patients with relapsed or refractory <i>FLT3</i>-mutated AML. Promising phase I and II efficacy data for quizartinib is likely to lead to a third regulatory approval in relapsed/refractory AML in the near future. However, despite the significant progress made in managing <i>FLT3</i>-mutated AML, many questions remain regarding the best approach to integrate these inhibitors into combination regimens, and also the optimal sequencing of different FLT3 inhibitors in various clinical settings. This review comprehensively examines the FLT3 inhibitors currently in clinical development, with an emphasis on their spectra of activity against different <i>FLT3</i> mutations and other kinases, clinical safety and efficacy data, and their current and future roles in the management of AML. The mechanisms of resistance to FLT3 inhibitors and potential combination strategies to overcome such resistance pathways are also discussed.
An international report on bacterial communities in esophageal squamous cell carcinoma (2021)

ABSTRACT The incidence of esophageal squamous cell carcinoma (ESCC) is disproportionately high in the eastern corridor of Africa and parts of Asia. Emerging research has identified a potential association between poor oral health and ESCC. One proposed biological pathway linking poor oral health and ESCC involves the alteration of the microbiome. Thus, we performed an integrated analysis of four independent sequencing efforts of ESCC tumors from patients from high- and low-incidence regions of the world. Using whole genome sequencing (WGS) and RNA sequencing (RNAseq) of ESCC tumors and WGS of synchronous collections of saliva specimens from 61 patients in Tanzania, we identified a community of bacteria, including members of the genera Fusobacterium, Selenomonas, Prevotella, Streptococcus, Porphyromonas, Veillonella , and Campylobacter , present at high abundance in ESCC tumors. We then characterized the microbiome of 238 ESCC tumor specimens collected in two additional independent sequencing efforts consisting of patients from other high-ESCC incidence regions (Tanzania, Malawi, Kenya, Iran, China). This analysis revealed a similar tumor enrichment of the ESCC-associated bacterial community in these cancers. Because these genera are traditionally considered members of the oral microbiota, we explored if there is a relationship between the synchronous saliva and tumor microbiomes of ESCC patients in Tanzania. Comparative analyses revealed that paired saliva and tumor microbiomes are significantly similar with a specific enrichment of Fusobacterium and Prevotella in the tumor microbiome. Together, these data indicate that cancer-associated oral bacteria are associated with ESCC tumors at the time of diagnosis and support a model in which oral bacteria are present in high abundance in both saliva and tumors of ESCC patients. Longitudinal studies of the pre-diagnostic oral microbiome are needed to investigate whether these cross-sectional similarities reflect temporal associations.