gebhart/patrepeval huggingface dataset:
Perioperative exercise capacity in chronic liver injury patients with hepatocellular carcinoma undergoing hepatectomy (2019)

Dynamic assessment of preoperative exercise capacity may be a useful predictor of postoperative prognosis. We aimed to clarify whether perioperative exercise capacity was related to long-term survival in hepatocellular carcinoma patients with chronic liver injury undergoing hepatectomy. One hundred-six patients with hepatocellular carcinoma underwent pre- and postoperative cardiopulmonary exercise testing to determine their anaerobic threshold, defined as the point between carbon dioxide production and oxygen consumption per unit of time. Testing involved 35 items including blood biochemistry analysis, in-vivo component analysis, dual-energy X-ray absorptiometry, and cardiopulmonary exercise testing preoperatively and 6 months postoperatively. We classified patients with anaerobic threshold ≥ 90% 6 months postoperatively compared with the preoperative level as the maintenance group (n = 78) and patients with anaerobic threshold < 90% as the decrease group (n = 28). Five-year recurrence-free survival rates were 39.9% vs. 9.9% (maintenance vs. decrease group) (hazard ratio: 1.87 [95% confidence interval: 1.12-3.13]; P = 0.018). Five-year overall survival rates were maintenance: 81.9%, and decrease: 61.7% (hazard ratio: 2.95 [95% confidence interval: 1.37-6.33]; P = 0.006). Multivariable Cox proportional hazards models showed that perioperative maintenance of anaerobic threshold was an independent prognostic indicator for both recurrence-free- and overall survival. Although the mean anaerobic threshold from preoperative to postoperative month 6 decreased in the exercise-not-implemented group, the exercise-implemented group experienced increased anaerobic threshold, on average, at postoperative month 6. The significant prognostic factor affecting postoperative survival for chronic liver injury patients with HCC undergoing hepatectomy was maintenance of anaerobic threshold up to 6 months postoperatively.
A Request-TDMA Multiple-Access Scheme for Wireless Multimedia Networks (1996)

This paper describes a cellular multiple-access scheme based on TDMA for multimedia communication networks. The scheme proposes an admission control of two different multimedia application stream types: real-time and non-real-time. We do not consider interference between cells. The proposed protocol, that is based on TDMA, exploits the available bandwidth fully. The throughput per mobile station is higher compared to other multiple-access protocols, it offers low latency for both real-time and non-real-time communication and the unused reserved bandwidth is reallocated for non-real-time communication. Furthermore, the throughput and latency remain stable under high loads.
Selenium–Selenium Bond Cleavage of Diaryl Diselenide Radical Anions During Pulse Radiolysis (2014)

Abstract Invited for this month’s cover are collaborators from the Institute of Scientific and Industrial Research (SANKEN), Osaka University and the National Institute of Advanced Industrial Science and Technology (AIST), Japan. The cover picture shows selenium–selenium σ‐bond cleavage of the di‐α‐naphthyl diselenide radical anion elucidated by transient absorption measurements during pulse radiolysis using the L‐band linear accelerator (background picture). Read the full text of the article at 10.1002/cplu.201402300 .
Therapeutic efficacy against Mycobacterium tuberculosis using ID93 and liposomal adjuvant formulations (2022)

<i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) has led to approximately 1.3 million deaths globally in 2020 according to the World Health Organization (WHO). More effective treatments are therefore required to prevent the transmission of <i>M.tb</i>. Although Bacille Calmette-Guérin (BCG), a prophylactic vaccine against <i>M.tb</i>, already exists, other vaccines are being developed that could help boost BCG's noted incomplete protection. This includes ID93 + GLA-SE, an adjuvanted protein vaccine which is being tested in Phase 2 clinical trials. The aim of this study was to test new lipid-based adjuvant formulations with ID93 in the context of a therapeutic vaccine, which we hypothesize would act as an adjunct to drug treatment and provide better outcomes, such as survival, than drug treatment alone. The recent success of another adjuvanted recombinant protein vaccine, M72 + AS01<sub>E</sub> (GlaxoSmithKline Biologicals), which after 3 years provided approximately 50% efficacy against TB pulmonary disease, is paving the way for new and potentially more effective vaccines. We show that based on selected criteria, including survival, T helper 1 cytokine responses, and resident memory T cells in the lung, that a liposomal formulation of GLA with QS-21 (GLA-LSQ) combined with ID93 provided enhanced protection over drug treatment alone.
Pegylated Interferon Alpha-Associated Optic Neuropathy (2010)

A 52-year-old man with chronic hepatitis C presented with painless, bilateral, simultaneous nonarteritic anterior ischemic optic neuropathy (NAION) and peripheral neuropathy. Symptoms began 19 weeks after starting peginterferon alpha-2a. The peripheral neuropathy and vision of the right eye improved, but the vision of the left eye worsened after stopping interferon. We identified 23 additional cases of NAION during interferon alpha therapy. At least 12 of these patients suffered bilateral NAION. Patients lost vision 1-40 weeks after initiating therapy. Of 21 eyes that had documented initial and follow-up acuities, 8 improved, 1 worsened, and the rest remained stable. One patient had a painful peripheral neuropathy. Treatment with interferon alpha may result in NAION. Discontinuation of therapy deserves consideration after weighing individual risks and benefits.
Preservation of rutin nanosuspensions without the use of preservatives (2019)

Nanocrystals are used as universal approach to improve the bioactivity of poorly soluble active ingredients. They are produced by various techniques, typically yielding aqueous nanosuspensions, which are prone to microbial contamination. Preservation of nanocrystals is possible but might not always be feasible, as preservatives might interfere with other excipients in the formulations or with chemicals used in assays, cell cultures or animal models. Therefore, to enable an easier use of nanocrystals, preservative-free nanosuspensions would be a good alternative. In this study, rutin nanocrystals were frozen and stored for three months at -20 °C. The chemical, physical and microbial stability were monitored, and the results were compared to preserved nanosuspensions. The frozen nanosuspensions remained stable and possessed excellent stability over the whole time of storage, indicating that the freeze-thaw process is suitable for the production of preservative-free nanosuspensions with excellent long-term stability. The freeze-thaw process for nanosuspensions is a simple concept and is suggested as alternative, when preserved nanosuspensions cannot be used.
Improving Periodic Flush Overhead of File Systems Using Non-volatile Buffer Cache (2014)

File I/O buffer cache plays an important role in narrowing the wide speed gap between the main memory and the secondary storage. However, data loss or inconsistencies may occur if the system crashes before the data that has been updated in the buffer cache is flushed to storage. Thus, most operating systems adopt a daemon that periodically flushes dirty data to the secondary storage. In this study, we show that periodic flushes account for 30-70% of the total write traffic to storage and remove this inefficiency by implementing a small, non-volatile buffer cache. Specifically, we present space-efficient management techniques, such as delta-write and fragment-grouping, and show that the storage write traffic and throughput can be improved by a margin of 44.2% and 23.6%, respectively, with only a small NVRAM.
Does Early Administration of Epidural Analgesia Affect Obstetric Outcome in Nulliparous Women Who Are in Spontaneous Labor? (1994)

Chestnut, David H.; McGrath, Joan M.; Vincent, Robert D. Jr.; Penning, Donald H.; Choi, Won W.; Bates, James N.; McFarlane, Claude Author Information
Chiral Analysis of Biogenic D,L-Amino Acids Derivatized by N-Fluorenylmethoxycarbonyl-L-alanyl N-Carboxyanhydride Using High-Performance Liquid Chromatography (2002)

Nineteen biogenic D,L-amino acids are derivatized with highly reactive N-fluorenylmethoxycarbonyl-L-alanyl N-carboxyanhydride. Using a 0.5M borate buffer at pH 7.5 and acetone, the derivatization of amino acids is completed in 5 min at room temperature. Some of the resulting diastereomeric N-protected dipeptides are successfully separated on an octylsilica stationary phase using 100mM acetate buffer (pH 4.4) and acetonitrile as the eluent.
PTPμ suppresses glioma cell migration and dispersal (2009)

The cell-surface receptor protein tyrosine phosphatase mu (PTPmu) is a homophilic cell adhesion molecule expressed in CNS neurons and glia. Glioblastomas (GBMs) are the highest grade of primary brain tumors with astrocytic similarity and are characterized by marked dispersal of tumor cells. PTPmu expression was examined in human GBM, low-grade astrocytoma, and normal brain tissue. These studies revealed a striking loss of PTPmu protein expression in highly dispersive GBMs compared to less dispersive low-grade astrocytomas and normal brain. We hypothesized that PTPmu contributes to contact inhibition of glial cell migration by transducing signals in response to cell adhesion. Therefore, loss of PTPmu may contribute to the extensive dispersal of GBMs. The migration of brain tumor cells was assessed in vitro using a scratch wound assay. Parental U-87 MG cells express PTPmu and exhibited limited migration. However, short-hairpin RNA (shRNA)-mediated knockdown of PTPmu induced a morphological change and increased migration. Next, a brain slice assay replicating the three-dimensional environment of the brain was used. To assess migration, labeled U-87 MG glioma cells were injected into adult rat brain slices, and their movement was followed over time. Parental U-87 MG cells demonstrated limited dispersal in this assay. However, PTPmu shRNA induced migration and dispersal of U-87 MG cells in the brain slice. Finally, in a mouse xenograft model of intracranially injected U-87 MG cells, PTPmu shRNA induced morphological heterogeneity in these xenografts. Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression.
Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations (2010)

The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers, and several agents targeting this pathway including PI3K/Akt/mammalian target of rapamycin inhibitors have recently entered clinical trials. One question is whether the efficacy of a PI3K pathway inhibitor can be predicted based on the activation status of pathway members. In this study, we examined the mutation, expression, and phosphorylation status of PI3K and Ras pathway members in a panel of 39 pharmacologically well-characterized human cancer cell lines (JFCR39). Additionally, we evaluated the in vitro efficacy of 25 PI3K pathway inhibitors in addition to conventional anticancer drugs, combining these data to construct an integrated database of pathway activation status and drug efficacies (JFCR39-DB). In silico analysis of JFCR39-DB enabled us to evaluate correlations between the status of pathway members and the efficacy of PI3K inhibitors. For example, phospho-Akt and KRAS/BRAF mutations prominently correlated with the efficacy and the inefficacy of PI3K inhibitors, respectively, whereas PIK3CA mutation and PTEN loss did not. These correlations were confirmed in human tumor xenografts in vivo, consistent with their ability to serve as predictive biomarkers. Our findings show that JFCR39-DB is a useful tool to identify predictive biomarkers and to study the molecular pharmacology of the PI3K pathway in cancer.
UNILATERAL OR BILATERAL TESTICULAR BIOPSY IN THE ERA OF INTRACYTOPLASMIC SPERM INJECTION (1999)

Bilateral testicular biopsies are superior to unilateral biopsies in the evaluation of patients with azoospermia. A 28% intra-individual difference in testicular pathology was seen after bilateral biopsies, and in 20% of patients focal spermatogenesis would have been missed after unilateral biopsy only. Due to the prognostic relevance of testicular biopsies for successful sperm retrieval before assisted reproduction, bilateral diagnostic testicular biopsies are recommended in the evaluation of patients with azoospermia.
Stretchable dipole antenna for body area networks at 2.45 GHz (2011)

A stretchable antenna is proposed for body area networks operating at 2.45 GHz. The topology of the antenna is based on a meandered dipole with a parasitic arm, which has an impedance with a dual-resonance behaviour. The antenna impedance is optimised for the specific radio-frequency integrated circuit where it will be connected to. This topology has been implemented on two stretchable technologies using thermoplastic poly-urethane and silicone as substrates. A simple stretching model has also been proposed for design purposes and it has been validated through measurements. Simulations based on this model and real stretching measurements have shown the potential of the structure for obtaining a wideband match in stretched conditions, with optimised designs achieving a reflection coefficient lower than −10 dB up to 20% stretching. On-body simulations and measurements have also been done, which indicate that practical values of reflection coefficient and radiation efficiency can be achieved with a separation of few millimetres between the antenna and the human body.
Experimental Evidence for Ca-Chloride Ion Pairs in the Interlayer of Montmorillonite. an XRD Profile Modeling Approach (2005)

Abstract Montmorillonite was equilibrated with high normality Cl − solutions to assess the possible presence of Me Cl + ion pairs in smectite interlayers suggested by chemical modeling of cation exchange experimental studies. Structural modifications induced by the presence of such ion pairs, and more especially those related to smectite hydration properties, were characterized from the modeling of experimental X-ray diffraction (XRD) profiles. As compared to those obtained from samples prepared at low ionic strength, XRD patterns from samples equilibrated in high ionic strength CaCl 2 solutions exhibited a small positional shift of 00 l basal reflections indicating a greater layer thickness. The rationality of basal reflection positions is also improved and the width of these reflections is decreased. These qualitative modifications are related to the existence of a more homogeneous hydration state with the sole presence at 40% relative humidity (RH) of bi-hydrated smectite layers (2W layers) in high ionic strength samples. By contrast, layers with contrasting hydration states coexist in samples prepared at low ionic strength. The stability of this homogeneous 2W hydration state is also extended towards low RH values in the sample prepared at high ionic strength. In addition, the intensity distribution is modified in samples prepared at high ionic strength as compared to those obtained at low ionic strength. In particular the relative intensity of the 002 reflection is strongly enhanced in the former samples. This modification arises from an increased electron density in the interlayer mid-plane of 2W layers which is best explained by the presence of cation-chloride ion pairs replacing the divalent cations occupying this structural position in low ionic strength samples. The increased amounts of interlayer species (ion pairs and H 2 O molecules), which are confirmed by nearinfrared diffuse reflectance spectroscopy results, and the larger size of CaCl + pairs as compared to Ca 2+ cations lead to a more stable layer thickness, probably as a result of decreased layer corrugation. Consistent results were obtained for Sr and Mg cations.
A Data Analysis Method for Software Performance Prediction (2002)

This paper explores the role of data analysis methods to support system-level designers in characterising the performance of embedded applications. In particular, we address the performance modelling of software applications running on an embedded microprocessor. We propose a data analysis method, which, on the basis of a parameterisation of the software functionality and the hardware architecture, is able to predict the number of execution cycles on an embedded processor. Experiments with standard computational code (sorting, mathematical computation) and with MPEG variable length decoding are presented to support this claim.
Status of initial testing of the H2SO4 section of the ILS experiment. (2007)

A sulfuric acid catalytic decomposer section was assembled and tested for the Integrated Laboratory Scale experiments of the Sulfur-Iodine Thermochemical Cycle. This cycle is being studied as part of the U. S. Department of Energy Nuclear Hydrogen Initiative. Tests confirmed that the 54-inch long silicon carbide bayonet could produce in excess of the design objective of 100 liters/hr of SO{sub 2} at 2 bar. Furthermore, at 3 bar the system produced 135 liters/hr of SO{sub 2} with only 31 mol% acid. The gas production rate was close to the theoretical maximum determined by equilibrium, which indicates that the design provides adequate catalyst contact and heat transfer. Several design improvements were also implemented to greatly minimize leakage of SO{sub 2} out of the apparatus. The primary modifications were a separate additional enclosure within the skid enclosure, and replacement of Teflon tubing with glass-lined steel pipes.
Recommendations for the use of fieldbuses at CERN in the LHC era (1996)

Throughout the LHC project fieldbuses will be required to connect and control equipment and devices of various types. It will be necessary to integrate both industrial equipment and custom designed devices. In order to increase efficiency of resources the working group recommends restricting the choice of fieldbuses, to be used in the years to come at CERN and by the various institutes collaborating in the LHC project, to three : CAN bus, PROFIBUS and WORLDFIP. Keywords : fieldbus, controls, standard, CAN, PROFIBUS, WORLDFIP
Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia (2020)

Acute myeloid leukemia (AML) is a heterogeneous and complex disease, and treatments for this disease have not been curative for the majority of patients. In younger patients, internal tandem duplication of FLT3 (FLT3-ITD) is a common mutation for which two inhibitors (midostaurin and gilteritinib) with varied potency and specificity for FLT3 are clinically approved. However, the high rate of relapse or failed initial response of AML patients suggests that the addition of a second targeted therapy may be necessary to improve efficacy. Using an unbiased large-scale CRISPR screen, we genetically identified BCL2 knockout as having synergistic effects with an approved FLT3 inhibitor. Here, we provide supportive studies that validate the therapeutic potential of the combination of FLT3 inhibitors with venetoclax in vitro and in vivo against multiple models of FLT3-ITD-driven AML. Our unbiased approach provides genetic validation for co-targeting FLT3 and BCL2 and repurposes CRISPR screening data, utilizing the genome-wide scope toward mechanistic understanding.
Catalysis by palladium salts. Part 2. Palladium-catalysed carboxylation with carbon monoxide of aromatic compounds working under mild conditions (1987)

The carboxylation with CO of aromatic C–H bonds, catalysed by palladium acetate, occurs with good yields and under mild conditions (1 atm † of CO and 20—50 °C), with trifluoroacetic acid as solvent and sodium acetate as co-catalyst. The reaction, which is stoicheiometric with respect to palladium, can be transformed into a pseudo-catalytic process by addition of an excess of a specific oxidant, which is consumed stoicheiometrically to regenerate palladium(II) continuously. The more efficient oxidants are mercury(II) acetate, thallium(III) trifluoroacetate, and sodium nitrate. With substituted aromatic derivatives, such as toluene and anisole, or condensed aromatic systems such as naphthalene, the pattern of the ring substitution is typical of electrophilic reactions, but in the presence of specific oxidants the regioselectivity of the ring substitution is increased with respect to the stoicheiometric reaction.
Scattering matrix determination by asymptotic analysis of complex scaled resonance wave functions: Model Cl+H2 nonadiabatic dynamics (1999)

It has previously been shown that partial widths of resonance states can be calculated by the asymptotic analysis of the complex scaled resonance wave function [U. Peskin, N. Moiseyev, and R. Lefebvre, J. Chem. Phys. 92, 2902 (1990)] and by the complex coordinate scattering theory [N. Moiseyev and U. Peskin, Phys. Rev. A 42, 255 (1990)]. Here we use these methods for the first time to calculate complex partial width amplitudes. The complex amplitudes are independent of the complex scaling parameters and are used for calculating the resonance contribution to the scattering matrix (the S matrix) in the case of Cl+H2 scattering described by two coupled one-dimensional potential energy curves. The background contribution to the S matrix was calculated by the use of one ClH2 potential energy curve only. The sum of the resonance and the background contributions provides accurate complex S matrix elements and transition probabilities, even at the resonance energy for which total reflection is obtained due to the interference between the two contributions.
Piezoelectricity of natural biomaterials (1984)

Abstract Shear piezoelectricity is observed in uniaxially oriented system of optically active biopolymers such as polysaccharides, polypeptides and polynucleotides. The magnitude of the piezoelectric constant is proportional to the degree of crystallinity, the degree of orientation and the piezoelectric constants in single crystal, as illustrated for wood. The superposition of instantaneous and relaxational polarizations may account for the sign reversal of the piezoelectric constant for oriented amylose film when temperature increases from - 150°C to 50°C. The piezoelectric constant for oriented polyhydroxybutyrate film is shown to be the sum of contributions from crystalline phase and oriented noncrystalline phase with opposite sign. The increase of the latter with increasing temperature may explain the relaxation of the piezoelectric constant at the glass transition around 20°C. When a d.c. field is biased, isotropic polymer systems such as gelatin may show apparent induced piezoelectricity through the stress-induced change of capacitance and conductivity. Application of a piezoelectric polymer film in vivo enhances the metabolic activity of bone cell and promotes osteogenesis.