gebhart/patrepeval huggingface dataset:
Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells (2014)

Interleukin-6 (IL-6), a multifunctional cytokine, contributes to proliferation or differentiation of prostate carcinoma cells in a highly cell type-specific manner. Celastrol (3-hydroxy-24-nor-2oxo-1(10),3,5,7-friedelatetrane-29-oic acid), also named as tripterine, is extracted from root of Chinese traditional herb Tripterygiumwilfordii Hook f with potent anti-inflammatory and anti-cancer activities. In this study, we evaluated the molecular mechanisms of celastrol on cell proliferation and IL-6 gene expression in prostate carcinoma cells. 3H-thymidine incorporation and flow cytometric analysis indicated that celastrol treatments arrested the cell cycle at the G0/G1 phase, thus attenuating cell proliferation in prostate carcinoma PC-3 cells; moreover, celastrol induced cell apoptosis at higher dosage. Knockdown of IL-6 attenuated the anti-proliferative effect of celastrol on PC-3 cells. Results from ELISA and 5'-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-κB response element within IL-6 promoter area since mutation of the NF-κB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. Celastrol also attenuated the activation of PMA and TNFα on the gene expression and secretion of IL-6 in PC-3 cells. Immunoblot assays revealed that celastrol treatment downregulated the expressions of IKKα, p50 and p65, supporting the 5'-deletion transient gene expression assay result that celastrol blocked IL-6 expression through the NF-κB pathway in PC-3 cells. For the first time, our results concluded that celastrol attenuates PC-3 cell proliferation via downregulation of IL-6 gene expression through the NF-κB-dependent pathway.
A new method for thermal dosimetry in microwave hyperthermia using microwave radiometry for temperature control (1987)

Microwave radiometry has been used during the last few years in some clinical centres (Lille, Freiburg, Strasbourg, Brussels) for the non-invasive control of temperature during microwave hyperthermia. The principal objective of this paper is to present an atraumatic thermal dosimetry system based on numerical simulations of hyperthermia and radiometric temperature measurements for TEM propagation. To gauge the feasibility and performance of the method, a one-dimensional model in a homogeneous medium is considered, neglecting the curvature of the tissue layer. The good correlation between the theoretical and experimental values obtained allowed the likely thermal profile on the probe axis to be computed using the dielectric and thermal properties of the medium and measurement of the radiometric and cutaneous temperatures.
Body mass index and risk of head and neck cancer in a pooled analysis of case–control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (2020)

Background Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases.
The estrogen receptor family (1999)

A significant flow of new data is currently being generated within the field of estrogen receptors and their mechanisms of action. This is primarily a result of the development of estrogen receptor knockout mice and the discovery of the second estrogen receptor, estrogen receptor beta. Both estrogen receptors appear to be involved in a multitude of regulatory events, the details of which will be worked out within the next few years. Estrogen receptor alpha appears to play a major role in the regulation of reproductive events and estrogen receptor alpha knockout female mice are completely infertile. Estrogen receptor beta knockout females have severe but incomplete infertility. Estrogen receptor beta gene mutations may, therefore, be of great clinical interest because they could perhaps explain some cases in which ovarian dysfunction leads to human infertility. Both receptors appear to be of essence for the cardiovascular system. Future studies will determine the relative importance of estrogen receptors alpha and beta in bone, the urogenital tract, the immune system, and the central nervous system, as well as in other estrogen target tissues.
Efficient Conjunctive Keyword-Searchable Encryption (2007)

A keyword-searchable encryption scheme allows a user with a "trapdoor" for a keyword to efficiently retrieve some of encrypted data containing the specific keyword over a remote server. The scheme for keyword-searchable encryption is considered as one of crucial building blocks that solves the security problems of privacy and data confidentiality in many settings, such as outsourced database systems and mail (or file) servers. However, most existing schemes support only a single keyword for searching, but do not allow for boolean combinations of keywords. It makes the use of schemes impractical in real applications. To address this problem, we propose an efficient construction for conjunctive keyword-searchable encryption, in which the size of trapdoors is almost same as that for searching a single keyword. Our construction is proven secure against adaptive chosen-keyword attacks in the random oracle model under the external co-Diffie-Hellman assumption. Compared to previous works, our construction has much better performance in terms of both computational and communication cost.
Tissue Inhibitor of Metalloproteinases-3 Inhibits Shedding of L-selectin from Leukocytes (1999)

Although the enzyme or enzymes mediating shedding of L-selectin have not yet been identified, this activity can be blocked by synthetic hydroxamic acid-based inhibitors of metalloproteinases such as Ro 31-9790. However, the endogenous matrix metalloproteinase inhibitor tissue inhibitor of metalloproteinases (TIMP)-1 does not block L-selectin shedding. Here, we report that TIMP-3, but not TIMP-2, inhibits L-selectin shedding from mouse and human lymphocytes, Jurkat T cells, and human monocytes. TIMP-3 has an IC50 of 0.3-0.4 microM on these cell types compared with 0.7-4.8 microM for Ro 31-9790. A metalloproteinase (tumor necrosis factor-alpha (TNF-alpha)-converting enzyme; ADAM17) has recently been identified which cleaves the pro-form of TNF-alpha to produce soluble cytokine. We compared inhibition of L-selectin shedding by TIMPs and Ro 31-9790 with inhibition of TNF-alpha shedding from human monocytes. TIMP-3 inhibited TNF-alpha shedding (IC50 of 0.1 microM), as did Ro 31-9790 (IC50 of 0.4 microM). TIMP-2 had a partial effect, and TIMP-1 did not inhibit. This study confirms that L-selectin sheddase is a metalloproteinase, but not a matrix metalloproteinase, and investigates the relationship between shedding of L-selectin and TNF-alpha.
Flexible displays using c-axis-aligned-crystal oxide semiconductors (2015)

We developed a c-axis-aligned-crystal In-Ga-Zn oxide (CAAC-IGZO) with a new composition that achieved higher field-effect mobility than a conventional CAAC-IGZO FET. The use of the new CAAC-IGZO for an active layer results in a channel-etched field-effect transistor (FET) with high mobility, normally-off characteristics, and high reliability. We fabricated a 13.3-inch 8K 664-ppi foldable organic light-emitting diode (OLED) display panel and the world's largest 81-inch 8K OLED kawara-type multi-display comprising white top-emission OLEDs with color filters employing the high-mobility CAAC-IGZO FETs in the backplane and using a transfer technology based on an inorganic separation layer.
Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer (2014)

The development of strategies for the inhibition of non‑small cell lung cancer (NSCLC) progression and metastasis have been mainly unsuccessful, in part due to insufficient mechanistic understanding of the disease. In the current study, the critical role of the co‑expression of immunoglobulin‑like transcript 4 (ILT4) and its ligands, angiopoietin‑like proteins (ANGPTLs), in the development of NSCLC was demonstrated. ILT4 and ANGPTL2 or ANGPTL5 were found to be co‑expressed in the five NSCLC cell lines that were investigated at the mRNA and protein level. Upon up‑ or downregulation of ILT4, the expression of ANGPTL2 was increased or reduced, respectively, while the expression of ANGPTL5 was unaffected. The co‑expression of ILT4 and ANGPTL2/ANGPTL5 was detected in human primary NSCLC tissues using immunohistochemical analysis. In total, 114 lung cancer specimens were included in the study; high expression of ILT4, ANGPTL2 and ANGPTL5 was observed in 58.8, 45.6 and 55.3%, respectively. The expression of ILT4 was found to be significantly correlated with a high expression level of ANGPTL2 (R=0.466, P=0.004); however, it was not correlated with the expression of ANGPTL5 (R=0.142, P=0.131). In ILT4‑positive samples, cases with ANGPTL2‑positive expression levels presented greater levels of lymph node metastasis (P=0.011) and shorter overall survival times (P=0.045). In addition, cases with ANGPTL5‑positive expression presented poor overall survival rates (P=0.040). By contrast, in the ILT4‑negative cases, no statistically significant differences were identified in the overall survival rates between samples with high and low expression of ANGPTL2 or ANGPTL5. In conclusion, the present study demonstrated the presence of interaction among ILT4 and ANGPTLs, which may be important in NSCLC progression. Therefore, the blockade of ANGPTLs or ILT4 may be an effective therapeutic approach for NSCLC treatment.
Compressive Network Analysis (2014)

Modern data acquisition routinely produces massive amounts of network data. Though many methods and models have been proposed to analyze such data, the research of network data is largely disconnected with the classical theory of statistical learning and signal processing. In this paper, we present a new framework for modeling network data, which connects two seemingly different areas: <i>network data analysis</i> and <i>compressed sensing</i>. From a nonparametric perspective, we model an observed network using a large dictionary. In particular, we consider the network clique detection problem and show connections between our formulation with a new algebraic tool, namely <i>Randon basis pursuit in homogeneous spaces</i>. Such a connection allows us to identify rigorous recovery conditions for clique detection problems. Though this paper is mainly conceptual, we also develop practical approximation algorithms for solving empirical problems and demonstrate their usefulness on real-world datasets.
Tail Asymptotics for Monotone-Separable Networks (2007)

A network belongs to the monotone separable class if its state variables are homogeneous and monotone functions of the epochs of the arrival process. This framework contains several classical queueing network models, including generalized Jackson networks, max-plus networks, polling systems, multiserver queues, and various classes of stochastic Petri nets. We use comparison relationships between networks of this class with independent and identically distributed driving sequences and the GI/GI/1/1 queue to obtain the tail asymptotics of the stationary maximal dater under light-tailed assumptions for service times. The exponential rate of decay is given as a function of a logarithmic moment generating function. We exemplify an explicit computation of this rate for the case of queues in tandem under various stochastic assumptions.
Ovulation Induction (2000)

In the woman with anovulation and polycystic ovarian syndrome, there are many options for ovulation induction. Treatment should be individualized, but clomiphene citrate is an excellent first-line agent. In the woman resistant to clomiphene citrate, combination therapy often results in pregnancy. Some women with PCOS only respond to gonadotropin therapy. These women are at a higher risk for multiple pregnancy and ovarian hyperstimulation syndrome. In the woman with anovulation and hypothalamic amenorrhea, the options for ovulation induction are limited. The luteal phase must be supported. The hypothalamus is unable to support the corpus luteum or early pregnancy.
Measurement of CH 3 and CH Densities in a Diamond Growth d.c. Discharge (1994)

A highly sensitive multielement optical-absorption method is used to measure the absolute column densities of both CH3 and CH in a d.c. plasma-assisted diamond chemical-vapor-deposition (CVD) system with an input gas of CH4 diluted in H2. The CH3 column density decreases slowly with distance from the cathode and increases with increasing CH4 input fraction. The CH density is sharply peaked near the cathode. The CH3 and CH densities are compared with measurements of the same radicals made in a hot-filament diamond CVD system.
Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults (2017)

Aging is associated with increased peripheral chemoreceptor activity, reduced nitric oxide (NO) bioavailability, and attenuation of cardiovagal baroreflex sensitivity (BRS), collectively increasing the risk of cardiovascular disease. Evidence suggests that NO may attenuate peripheral chemoreflex sensitivity and increase BRS. Exogenous inorganic nitrate ([Formula: see text]) increases NO bioavailability via the [Formula: see text]-[Formula: see text]-NO pathway. Our hypothesis was that inorganic [Formula: see text] supplementation would attenuate peripheral chemoreflex sensitivity and enhance spontaneous cardiovagal BRS in older adults. We used a randomized, placebo-controlled crossover design in which 13 older (67 ± 3 yr old) adults ingested beetroot powder containing (BR<sub>A</sub>) or devoid of (BR<sub>P</sub>) [Formula: see text] and [Formula: see text] daily over 4 wk. Spontaneous cardiovagal BRS was assessed over 15 min of rest and was quantified using the sequence method. Chemoreflex sensitivity was assessed via ~5 min of hypoxia (10% fraction of inspired O<sub>2</sub>) and reported as the slope of the relationship between O<sub>2</sub> saturation (%[Formula: see text]) and minute ventilation (in l/min) or heart rate (in beats/min). Ventilatory responsiveness to hypoxia was reduced after BR<sub>A</sub> (from -0.14 ± 0.04 to -0.05 ± 0.02 l·min<sup>-1</sup>·%[Formula: see text]<sup>-1</sup>, P = 0.01) versus BR<sub>P</sub> (from -0.10 ± 0.05 to -0.11 ± 0.05 l·min<sup>-1</sup>·%[Formula: see text]<sup>-1</sup>, P = 0.80), with no differences in heart rate responsiveness (BR<sub>A</sub>: from -0.47 ± 0.06 to -0.33 ± 0.04 beats·min<sup>-1</sup>·%[Formula: see text]<sup>-1</sup>, BR<sub>P</sub>: from -0.48 ± 0.07 to -0.42 ± 0.06 beats·min<sup>-1</sup>·%[Formula: see text]<sup>-1</sup>) between conditions (interaction effect, P = 0.41). Spontaneous cardiovagal BRS was unchanged after BR<sub>A</sub> and BR<sub>P</sub> (interaction effects, P = 0.69, 0.94, and 0.39 for all, up, and down sequences, respectively), despite a reduction in resting systolic and mean arterial blood pressure in the experimental (BR<sub>A</sub>) group ( P < 0.01 for both). These findings illustrate that inorganic [Formula: see text] supplementation attenuates peripheral chemoreflex sensitivity without concomitant change in spontaneous cardiovagal BRS in older adults. NEW & NOTEWORTHY Exogenous inorganic nitrate supplementation attenuates ventilatory, but not heart rate, responsiveness to abbreviated hypoxic exposure in older adults. Additionally, inorganic nitrate reduces systolic and mean arterial blood pressure without affecting spontaneous cardiovagal baroreflex sensitivity. These findings suggest that inorganic nitrate may attenuate sympathetically oriented pathologies associated with aging.
Capability of CT Body Scanning and Ultrasonography to Demonstrate the Status of the Biliary Ductal System in Patients with Jaundice (1978)

In this paper we propose a prototype model for the problem of managing waiting lists for organ transplantations. Our model captures the double-queue nature of the problem: there is a queue of patients, but also a queue of organs. Both may suffer from "impatience": the health of a patient may deteriorate, and organs cannot be preserved longer than a certain amount of time. Using advanced tools from queueing theory, we derive explicit results for key performance criteria: the rate of unsatisfied demands and of organ outdatings, the steady-state distribution of the number of organs on the shelf, the waiting time of a patient, and the long-run fraction of time during which the shelf is empty of organs.
On the update of term weights in dynamic information retrieval systems (1995)

Article Free Access Share on On the update of term weights in dynamic information retrieval systems Authors: Charles L. Viles Department of Computer Science, University of Virginia, Charlottesville, VA Department of Computer Science, University of Virginia, Charlottesville, VAView Profile , James C. French Department of Computer Science, University of Virginia, Charlottesville, VA Department of Computer Science, University of Virginia, Charlottesville, VAView Profile Authors Info & Claims CIKM '95: Proceedings of the fourth international conference on Information and knowledge managementDecember 1995 Pages 167–174https://doi.org/10.1145/221270.221561Published:02 December 1995Publication History 7citation406DownloadsMetricsTotal Citations7Total Downloads406Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Mobile Phone-Enabled Museum Guidance with Adaptive Classification (2008)

We present an overview of our adaptive museum guidance system called PhoneGuide. It uses camera-equipped mobile phones for on-device object recognition in ad-hoc sensor networks and provides location and object aware multimedia content to museum visitors.
Strength and Microstructure of Silicon Nitride Fabricated by Post-Sintering Process Using Low-Purity Silicon Powder as Raw Materials (2004)

Influence of sintering temperature on the strength and micro-structure were investigated on silicon nitride specimens fabricated by pressureless post-sintering process using low-purity silicon powder as raw materials. Densification of reaction-bonded silicon nitride with sintering aid did not proceed further upon setting the post-sintering temperature at 1600 or 1650°C due to the volatilization of species and poor sinterbility. Sintering at 1850°C provided almost fully densified silicon nitride having an average strength of 521 MPa, the grains of this materials were relatively fine but did not develop into a rod-like shape.
Automatic segmentation of the preterm neonatal brain with MRI using supervised classification (2013)

Cortical folding ensues around 13-14 weeks gestational age and a qualitative analysis of the cortex around this period is required to observe and better understand the folds arousal. A quantitative assessment of cortical folding can be based on the cortical surface area, extracted from segmentations of unmyelinated white matter (UWM), cortical grey matter (CoGM) and cerebrospinal fluid in the extracerebral space (CSF). This work presents a method for automatic segmentation of these tissue types in preterm infants. A set of T1- and T2-weighted images of ten infants scanned at 30 weeks postmenstrual age was used. The reference standard was obtained by manual expert segmentation. The method employs supervised pixel classification in three subsequent stages. The classification is performed based on the set of spatial and texture features. Segmentation results are evaluated in terms of Dice coefficient (DC), Hausdorff distance (HD), and modified Hausdorff distance (MHD) defined as 95th percentile of the HD. The method achieved average DC of 0.94 for UWM, 0.73 for CoGM and 0.86 for CSF. The average HD and MHD were 6.89 mm and 0.34 mm for UWM, 6.49 mm and 0.82 mm for CoGM, and 7.09 mm and 0.79 mm for CSF, respectively. The presented method can provide volumetric measurements of the segmented tissues, and it enables quantification of cortical characteristics. Therefore, the method provides a basis for evaluation of clinical relevance of these biomarkers in the given population.
Stochastic Matching Problem (2011)

The matching problem plays a basic role in combinatorial optimization and in statistical mechanics. In its stochastic variants, optimization decisions have to be taken given only some probabilistic information about the instance. While the deterministic case can be solved in polynomial time, stochastic variants are worst-case intractable. We propose an efficient method to solve stochastic matching problems which combines some features of the survey propagation equations and of the cavity method. We test it on random bipartite graphs, for which we analyze the phase diagram and compare the results with exact bounds. Our approach is shown numerically to be effective on the full range of parameters, and to outperform state-of-the-art methods. Finally we discuss how the method can be generalized to other problems of optimization under uncertainty.
Optimal training for emergency needle thoracostomy placement by prehospital personnel (2014)

In a CBT module, US Navy corpsmen were better trained to place NT accurately than their traditional didactic SBL counterparts. Further studies are indicated to identify the optimal components of effective simulation training for NT and other emergent interventions.
Evolution and structure of clinically relevant gene fusions in multiple myeloma (2020)

Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research Foundation CoMMpass Study. Patients with multiple clinic visits enable us to track tumor and fusion evolution, and cases with matching peripheral blood and bone marrow samples allow us to evaluate the concordance of fusion calls in patients with high tumor burden. We examine the joint upregulation of WHSC1 and FGFR3 in samples with t(4;14)-related fusions, and we illustrate a method for detecting fusions from single cell RNA-seq. We report fusions at MYC and a neighboring gene, PVT1, which are related to MYC translocations and associated with divergent progression-free survival patterns. Finally, we find that 4% of patients may be eligible for targeted fusion therapies, including three with an NTRK1 fusion.