gebhart/patrepeval huggingface dataset:
Solubility of Solids in Sub- and Supercritical Fluids: a Review (2011)

A review of solubility data for solid compounds in sub- and supercritical fluids published in the literature between 2005 and 2010 is given in tabular form along with the temperature and pressure ranges and the correlation methods applied by the authors for modeling the experimentally determined data. Compounds are classified into groups on the basis of their chemical nature (inorganic, organometallic, aromatic, nonaromatic organic, polymer), except for biological and pharmaceutical compounds, which are considered as a separate group based on their functionality. For each group of compounds, new findings are reviewed and discussed. Supercritical CO2 was the preferred solvent for most of the applications, although an increasing interest in other solvents at elevated pressure has been observed, especially for fluorinated hydrocarbons, water, and propane.
Reactive Oxygen Species Explicit Dosimetry for Photofrin‐mediated Pleural Photodynamic Therapy (2019)

Explicit dosimetry of treatment light fluence and implicit dosimetry of photosensitizer photobleaching are commonly used methods to guide dose delivery during clinical PDT. Tissue oxygen, however, is not routinely monitored intraoperatively even though it is one of the three major components of treatment. Quantitative information about in vivo tissue oxygenation during PDT is desirable, because it enables reactive oxygen species explicit dosimetry (ROSED) for prediction of treatment outcome based on PDT-induced changes in tumor oxygen level. Here, we demonstrate ROSED in a clinical setting, Photofrin-mediated pleural photodynamic therapy, by utilizing tumor blood flow information measured by diffuse correlation spectroscopy (DCS). A DCS contact probe was sutured to the pleural cavity wall after surgical resection of pleural mesothelioma tumor to monitor tissue blood flow (blood flow index) during intraoperative PDT treatment. Isotropic detectors were used to measure treatment light fluence and photosensitizer concentration. Blood-flow-derived tumor oxygen concentration, estimated by applying a preclinically determined conversion factor of 1.5 × 10<sup>9</sup> μMs cm<sup>-2</sup> to the blood flow index, was used in the ROSED model to calculate the total reacted reactive oxygen species [ROS]rx. Seven patients and 12 different pleural sites were assessed and large inter- and intrapatient heterogeneities in [ROS]rx were observed although an identical light dose of 60 J cm<sup>-2</sup> was prescribed to all patients.
Optimized Pump Systems Improve Performance (2018)

To reliably operate pumping systems near best efficiencies, identify and monitor indicators of degraded performance so your utility can maintain, or overhaul, pumps as needed.
Effectiveness of low-dose intravenous immunoglobulin therapy in minor primary antibody deficiencies: A 2-year real-life experience (2021)

Primary antibody deficiencies (PAD) are the most prevalent group of primary immunodeficiencies (PID) in adults and immunoglobulin replacement therapy (IRT) is the mainstay therapy to improve clinical outcomes. IRT is, however, expensive and, in minor PAD, clear recommendations concerning IRT are lacking. We conducted a retrospective real-life study to assess the effectiveness of low-dose IRT in minor PAD on 143 patients fulfilling European Society for Immunodeficiencies (ESID) diagnostic criteria for immunoglobulin (Ig)G subclass deficiency (IgGSD) or unclassified antibody deficiency (UAD). All patients were treated with intravenous low-dose IRT (0.14 ± 0.06 g/kg/month). Immunoglobulin (Ig) classes and IgG subclasses were measured at baseline and after 1 year of IRT. The annual rate of total infections, upper respiratory tract infections (URTI), lower respiratory tract infections (LRTI) and hospitalizations was measured at baseline and after 1 and 2 years of IRT. After 1 year of IRT significant improvement was demonstrated in: (a) serum IgG (787.9 ± 229.3 versus 929.1 ± 206.7 mg/dl; p < 0.0001); (b) serum IgG subclasses (IgG1 = 351.4 ± 109.9 versus 464.3 ± 124.1, p < 0.0001; IgG2 = 259.1 ± 140 versus 330.6 ± 124.9, p < 0.0001; IgG3 = 50.2 ± 26.7 versus 55.6 ± 28.9 mg/dl, p < 0.002); (c) annual rate of total infections (5.75 ± 3.87 versus 2.13 ± 1.74, p < 0.0001), URTI (1.48 ± 3.15 versus 0.69 ± 1.27; p < 0.005), LRTI (3.89 ± 3.52 versus 1.29 ± 1.37; p < 0.0001) and hospitalizations (0.37 ± 0.77 versus 0.15 ± 0.5; p < 0.0002). The improvement persisted after 2 years of IRT. No significant improvement in URTI annual rate was noted in UAD and in patients with bronchiectasis. In conclusion, low-dose IRT can improve clinical outcomes in UAD and IgGSD patients, providing a potential economical advantage over the standard IRT dose.
Improvement of Calculation Speed of NEC-2 Code Using CUDA and OpenMP (2018)

전자파 수치 해석 기법 중 모멘트법(MoM : Method of Moment)에 기반한 NEC-2 코드는 대용량 행렬을 계산하는데 어려움이 있다. 본 논문에서는 계산 시간이 많이 걸리는 NEC-2 코드에 대하여 병렬처리 기법을 적용하여 계산 속도를 향상시켰다. NEC-2 코드의 모멘트 산란 행렬 계산부는 복잡한 제어 연산이 필요함에 따라 병렬코어 기반의 OpenMP(Open Muti-Processing)를 적용하였으며, NEC-2 코드의 가우스 소거법을 통해 계산되는 역행렬 연산에는 고속 병렬화가 가능하도록 하는 CUDA(Compute Unified Device Architecture)기반의 cuBLAS를 적용하였다. 시뮬레이션 결과 동일한 표적에 대하여 기존의 NEC-2코드와 계산 결과가 잘 일치하며, 해석 속도는 약 12배 이상 향상됨을 확인하였다.
FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells (2016)

Glioblastoma multiforme (GBM) continues to be the most frequently diagnosed and lethal primary brain tumor. Adjuvant chemo-radiotherapy remains the standard of care following surgical resection. In this study, using reverse phase protein arrays (RPPAs), we assessed the biological effects of radiation on signaling pathways to identify potential radiosensitizing molecular targets. We identified subsets of proteins with clearly concordant/discordant behavior between irradiated and non-irradiated GBM cells in vitro and in vivo. Moreover, we observed high expression of Forkhead box protein M1 (FOXM1) in irradiated GBM cells both in vitro and in vivo. Recent evidence of FOXM1 as a master regulator of metastasis and its important role in maintaining neural, progenitor, and GBM stem cells, intrigued us to validate it as a radiosensitizing target. Here we show that FOXM1 inhibition radiosensitizes GBM cells by abrogating genes associated with cell cycle progression and DNA repair, suggesting its role in cellular response to radiation. Further, we demonstrate that radiation induced stimulation of FOXM1 expression is dependent on STAT3 activation. Co-immunoprecipitation and co-localization assays revealed physical interaction of FOXM1 with phosphorylated STAT3 under radiation treatment. In conclusion, we hypothesize that FOXM1 regulates radioresistance via STAT3 in GBM cells. We also, show GBM patients with high FOXM1 expression have poor prognosis. Collectively our observations might open novel opportunities for targeting FOXM1 for effective GBM therapy.
The Uteroglobin Gene G38A Polymorphism Is Not Associated with Kawasaki Disease (2010)

Title The Uteroglobin Gene G38A Polymorphism Is Not Associated with Kawasaki Disease Author(s) Nakashima, Kazuhisa; Ikeda, Kazuyuki; Nishimura, Shinji; Shibata, Yoshisada; Motomura, Hideki; Ohno, Takuro; Zaitsu, Masafumi; Hara, Toshiro; Hamasaki, Yuhei; Moriuchi, Hiroyuki Citation Acta medica Nagasakiensia, 54(3), pp.53-58 ; 2010 Issue Date 2010-03 URL http://hdl.handle.net/10069/23118 Right NAOSITE: Nagasaki University's Academic Output SITE
Strain-Compensated Multiple Quantum Wells Laser on GaAs Cavity (1994)

We present a novel low temperature bonding tech- nique for fabricating long wavelength vertical cavity surface emitting lasers (VCSEL's). The technique relies on a 750 hi-thick intermediate spin-on glass layer to join a highly efficient InP- based InGaAs-InGaAsP strain-compensated multiple quantum well (SC-MQW) gain medium on a GaAs substrate. We fabricated the device on GaAs in order to take advantage of highly reflective AIAs-GaAs Bragg reflectors. The optically-pumped device has a low threshold pump power of 4.2 kW/cm2 at room temperature and operates at a wavelength of 1.44 pm.
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. (1994)

The p53 tumor suppressor gene product is a transcriptional regulatory protein. It activates transcription from promoters that contain a p53 DNA binding site but represses many promoters that lack its binding site. High-level expression of wild-type p53 can induce apoptosis in certain cell types, and this activity can be blocked by the adenovirus E1B 19-kDa oncoprotein or by the cellular Bcl-2 oncoprotein. Here we report that p53-mediated repression of promoters that lack a p53 binding site is abrogated by the E1B 19-kDa protein or Bcl-2 oncoprotein. In contrast, transcriptional activation by p53 still occurs in the presence of either protein. The fact that two oncoproteins capable of preventing p53-mediated apoptosis also block transcriptional repression by p53 raises the possibility that p53 might induce apoptosis, at least in part, by repressing transcription.
Programming Internet telephony services (1999)

Internet telephony enables a wealth of new service possibilities. Traditional telephony services such as call forwarding, transfer, and 800 number services, can be enhanced by interaction with e-mail, Web, and directory services. Additional media types, like video and interactive chat, can be added as well. One of the challenges in providing these services is how to effectively program them. Programming these services requires decisions regarding where the code executes, how it interfaces with the protocols that deliver the services, and what level of control the code has. In this article we consider this problem in detail. We develop requirements for programming Internet telephony services, and we show that at least two solutions are required-one geared for service creation by trusted users (such as administrators), and one geared for service creation by untrusted users (such as consumers). We review existing techniques for service programmability in the Internet and in the telephone network, and extract the best components of both. The result is a common gateway interface that allows trusted users to develop services, and the call processing language that allows untrusted users to develop services.
ChemInform Abstract: Use of 1,1′‐Binaphthalene‐8,8′‐diol as a Chiral Auxiliary for Asymmetric Michael Addition. Application to the Syntheses of Turmeronol A and B. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. (1995)

Recent studies have demonstrated that reduced insulin-stimulated muscle glycogen synthesis is the major cause of insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM). This reduced rate has been assigned to a defect in either glucose transport or hexokinase activity. However it is unknown whether this is a primary or acquired defect in the pathogenesis of NIDDM. To examine this question, we measured the rate of muscle glycogen synthesis and the muscle glucose 6-phosphate (G6P) concentration using 13C and 31P NMR spectroscopy as well as oxidative and nonoxidative glucose metabolism in six lean, normoglycemic offspring of parents with NIDDM and seven age/weight-matched control subjects under hyperglycemic (approximately 11 mM)-hyperinsulinemic (approximately 480 pM) clamp conditions. The offspring of parents with NIDDM had a 50% reduction in total glucose metabolism, primarily due to a decrease in the nonoxidative component. The rate of muscle glycogen synthesis was reduced by 70% (P < 0.005) and muscle G6P concentration was reduced by 40% (P < 0.003), which suggests impaired muscle glucose transport/hexokinase activity. These changes were similar to those previously observed in subjects with fully developed NIDDM. When the control subjects were studied at similar insulin levels (approximately 440 pM) but euglycemic plasma glucose concentration (approximately 5 mM), both the rate of glycogen synthesis and the G6P concentration were reduced to values similar to the offspring of parents with NIDDM. We conclude that insulin-resistant offspring of parents with NIDDM have reduced nonoxidative glucose metabolism and muscle glycogen synthesis secondary to a defect in muscle glucose transport/hexokinase activity prior to the onset of overt hyperglycemia. The presence of this defect in these subjects suggests that it may be the primary factor in the pathogenesis of NIDDM.
A sensor network application construction kit (SNACK) (2004)

We propose a new configuration language, component and service library, and compiler that make it easier to develop efficient sensor network applications. Our goal is the construction of smart application service libraries: high-level libraries that implement concepts like routing trees and periodic sensing, and that combine automatically into efficient programs. Important language features include flexible control over component sharing and transitive arrow connections, which let independently-implemented services knit themselves into integrated control flow paths. Our language, library, and compiler are collectively called SNACK (Sensor Network Application Construction Kit). We describe them, and present and evaluate a simple SNACK-based multihop data collection application. This application uses SNACK language features to provide both simplicity (excluding reusable service definitions, its description is three lines long) and efficiency (it performs comparably to the well-known Surge application).
Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation (2018)

Abstract Cochlear gene therapy holds promise for the treatment of genetic deafness. Assessing its impact in adult murine models of hearing loss, however, has been hampered by technical challenges that have made it difficult to establish a robust method to deliver transgenes to the mature murine inner ear. Here in we demonstrate the feasibility of a combined round window membrane injection and semi-circular canal fenestration technique in the adult cochlea. Injection of both AAV2/9 and AAV2/Anc80L65 via this approach in P15–16 and P56–60 mice permits robust eGFP transduction of virtually all inner hair cells throughout the cochlea with variable transduction of vestibular hair cells. Auditory thresholds are not compromised. Transduction rate and cell tropism is primarily influenced by viral titer and AAV serotype but not age at injection. This approach is safe, versatile and efficient. Its use will facilitate studies using cochlear gene therapy in murine models of hearing loss over a wide range of time points.
Treatment-resistant depression in an elderly patient with pancreatic carcinoma: case report. (1984)

A case is reported of a recurrent and treatment-resistant depression with a positive DST in an individual in whom adenocarcinoma of the pancreas was eventually diagnosed. Following excision of the tumor, there was increased therapeutic response to antidepressants and normalization of the DST.
Cannabinoids Induce Immunoglobulin Class Switching to IgE in B Lymphocytes (2009)

Cannabinoid treatment increases Th2 activity and previous reports showed B cells express the highest level of CB2 mRNA relative to other immune cells suggesting that cannabinoids play a critical role in B cell activation and maturation. To examine the direct effect of cannabinoids on B cell antibody class switching, mouse splenic B cells were purified by negative selection and cultured with IL4 and anti-CD40 in the presence or absence of the nonselective cannabinoid agonist, CP55940, or the CB1 selective agonist, methanandamide, or the CB2 selective agonist, JW015. The cultures were then analyzed at different times by flow cytometry for expression of B cell surface markers, such as CD19, CD138, CD40, MHCII, CD23, CD80, CD45R, immunoglobulins produced such as IgM, IgE, IgD, and IgG1, and Toll-like receptors such as TLR 2 and 4. Cells treated with CP55940 showed an increase in surface expression of IgE by day 5 in culture; methanandamide had no effect. CP55940 also induced an increase in secreted IgE in culture supernatants analyzed by ELISA. In addition, CB2 receptors were increased on B cells following stimulation with IL-4 and anti-CD40 and the class switching effect of CP55940 was attenuated by the CB2 antagonist, SR144528.\nWe also observed that cannabinoid treatment of B cells modulates cell functions other than antibody class switching such as surface marker and TLR expression. CP55940 caused a significant increase in surface expression of TLR 4, but had no effect on other markers. Additional experiments with cannabinoid receptor selective agonists and antagonists suggested both CB1 and CB2 receptors were involved in the TLR effect. Receptor involvement and Gi coupling was supported by our findings that cannabinoids inhibit intracellular cAMP levels in forskolin stimulated B cells, and increasing intracellular cAMP with forskolin suppressed IgE antibody class switching in activated B cell cultures. These results suggest cannabinoids negatively regulate cAMP in B cells resulting in increased IgE. In conclusion, cannabinoids can directly affect the function of B cells by inducing antibody class switching to IgE and TLR4 expression through mechanisms involving CB1 and CB2 receptors suggesting the endocannabinoid system may be an important regulator of humoral immunity and the allergic response.
Bioluminescence of Marine Dinoflagellates (1962)

Portable light-baffled underwater photometers have been designed for the measurement of dinoflagellate bioluminescence by day and night. Maximal light emission is obtained by mechanical stimulation in a defined volume. The pump which stimulates the dinoflagellates also constantly replenishes the sample volume so that continuous measurements are possible. Evidence for both diurnal variation and vertical migration is presented. Using luminous bacteria for calibration a single dinoflagellate has been found to emit of the order of 10(10) light quanta per flash. The technique suggests that large scale mapping of bioluminescence is feasible.
Ordered Conformation of Succinoglycan in Aqueous Sodium Chloride (2001)

Succinoglycan samples ranging in weight-average molecular weight from 1.0 x 10(5) to 8.7 x 10(6) (in 0.1 M aqueous NaCl at 25 degrees C), prepared by ultrasonication of a native sample (Rheozan), followed by fractionation, were investigated by static light scattering, sedimentation equilibrium, and viscometry in 0.1 M aqueous NaCl at 25 degrees C where the polysaccharide assumes a certain ordered (helical) conformation. The measured radii of gyration and intrinsic viscosities showed the polysaccharide to behave like a semirigid chain in the aqueous salt. Their analysis based on the unperturbed wormlike chain yielded about 1500 nm-1 and 50 nm for the linear mass density and the persistence length, respectively. The former value was almost twice that expected for the single succinoglycan molecule, and thus it was concluded that the predominant molecular species of succinoglycan present in the aqueous salt is a double helix or an aggregate composed of paired single helices.
논문 : 과학기술자의 사회적 책임에 관한 논의의 재검토 (2008)

이 논문에서는 과학기술학의 연구성과를 바탕으로 과학기술의 윤리적 측면에 대한 기존의 논의를 보완하거나 새로운 논점을 제기함으로써 과학기술자의 사회적 책임에 관한 체계적인 기획을 시도하였다. 첫째, 과학기술자의 사회적 책임에 관한 객관적 조건으로서 과학과 기술이 제도화되면서 사회와 긴밀한 관계를 형성하고 있다는 점을 지적하였다. 둘째, 과학기술의 공공성을 부각시킴으로써 기존의 전문직업인으로서의 과학기술자에 대한 논의를 보완하였다. 셋째, 과학기술자의 윤리적 갈등을 몇 개의 유형으로 분류한 후 관련된 사회집단을 포괄적으로 고려하면서 윤리적으로 수용가능한 대안을 모색해야 한다는 점을 지적하였다. 넷째, 과학기술자의 사회적 책임을 강화하기 위한 과제로서 부도덕한 행위에 관한 문제제기, 전문가적 증인의 역할 수행, 과학기술단체의 윤리강령 제정, 과학기술윤리교육의 강화를 제안하였다. 이러한 논의는 사회적 중요성이 점점 증대하고 있는 과학기술자가 자신의 활동을 보다 거시적 맥락에서 살펴볼 수 있는 매개체로 작용할 수 있다.
Diabetic Patients Foot Care Using Smart Materials to Prevent Ulcerations/Amputations (2002)

A major cause of illness and disability in diabetic patients are complications affecting the lower limbs, in particular, the feet. It is believed that elevated plantar pressure plays a major role in foot problems in diabetic patients. It is proposed that high foot pressure concentrations may be avoided by developing a novel shoe insert based on the mechanics of smart materials. This paper describes the conceptual design of an automatic system that continuously monitors and controls the pressure levels in diabetic patients feet. The scheme is based on the constant measurement of pressure levels and an active change in the shape of the shoe insert so as to decrease high-pressure levels. Sensing and actuation is done by the use of smart materials powered by a battery pack in the insert. All of the circuitry is envisioned to be on a single VLSI chip embedded in the shoe insert, hence making the shoe insert completely autonomous. Genetic algorithms will be used to select the optimal shapes and hence provide the smart materials with the correct voltage inputs so as to alter the shape of the insert. The greatest strength of the system is that it will be an active real-time system that will adapt to changes in the locations of high stress points, hence being superior to currently used passive shoe inserts and other forms of diabetic foot care. The focus of this paper is to show the preliminary use of genetic algorithms to quickly select an optimal shape that can be created by discretely placed actuators so as to reduce the high levels of plantar pressures.
Training the sex educator: guidelines for teacher training institutions. (1972)

Training the sex educator: guidelines for teacher training institutions. M A CarreraCopyRight https://doi.org/10.2105/AJPH.62.2.233 Published Online: October 07, 2011
Impact of Postoperative Annular Diameter on Mid-term Outcomes of Aortic Valve Repair (2019)

Background: A normal function of the aortic valve after repair can be only achieved by simultaneous restoration of normal aortic root dimensions and cusp geometry. Ventriculoaortic junction (VAJ) diameter and effective cusp height have been reported to predict the outcome after aortic valve repair procedures. We aimed to analyze the impact of postoperative VAJ diameter on functional outcomes after aortic valve repair in a consecutive cohort of patients during the past 3 years.
Efficient frequency doubling of self-starting additive-pulse mode-locked diode-pumped Nd:YAG and Nd:YLF laser (1991)

Self starting additive pulse mode-locking was first achieved in Ti:Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt; and was a significant development in the production of ultra short pulses. The technique utilises the phase dependent reflectivity from a resonant coupled cavity being intensity dependent due to the nonlinear element present. An initial intensity perturbation resulting from mode beating in the main laser is, in the presence of sufficient nonlinear feedback, progressively shortened and preferentially amplified on successive round trips, and grows to saturate the gain, resulting in steady state mode-locking. By removing the need for active made-locking, with its associated synchronisation problems, ultra short pulse durations were readily achieved, combined with a general simplification of the overall system. The wide applicability of the scheme has been demonstrated by its extension to other solid state gain media such as Nd:YAG, Nd:YLF and Nd:Glass.