gebhart/patrepeval huggingface dataset:
Surgery for female stress urinary incontinence. (1995)

With the advent of magnetic resonance imaging, the treatment of female incontinence has undergone a renaissance. This change has primarily been due to superior understanding of anatomy and function of the supports of the urethra, bladder neck and bladder base in the female pelvis.
Towards industrial products from microalgae (2016)

Model projections show that production of high-value products from microalgae could be profitable nowadays and commodities will become profitable within 10 years.
Nitrogen metabolism in cancer patients. (1981)

The methods of examining nitrogen metabolism in cancer-bearing humans are examined with specific examples. The major nutritional effect of cancer on the host is lean tissue and caloric reserve dissolution, with increased total body water. It seems clear that gluconeogenesis from amino acids can be suppressed by exogenous substrate. With appropriate nutritional repletion, protein catabolism can be suppressed and synthesis stimulated.
Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus (1994)

The structure of RP 71955, a new tricyclic 21 amino acid peptide active against human immunodeficiency virus 1, was determined. Its amino acid composition was inferred from the results of fast atom bombardment mass spectrometry, nuclear magnetic resonance, Raman spectroscopy, and amino acid analysis. Its sequence could not be determined classically, using Edman degradation, given the lack of a free terminal NH2. It was deduced from the interpretation of interresidue nuclear Overhauser effects and confirmed by the sequencing of peptides obtained by limited chemical hydrolysis. It was found to be CLGIGSCNDFAGCGYAVVCFW. An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. The three-dimensional structure of RP 71955 was determined from nuclear magnetic resonance derived constraints using distance geometry, restrained molecular dynamics, nuclear Overhauser effect back calculation, and an iterative refinement using a full relaxation matrix approach. Analogies between the structure of RP 71955 and some functional domains of gp41, the transmembrane protein of human immunodeficiency virus 1, suggest hypotheses concerning the mode of action of RP 71955.
A pervasive solution for risk awareness in the context of fall prevention (2009)

In the present work, we introduce Fallarm, a pervasive fall prevention solution suitable for hospitals and care facilities, as well as for home settings. We applied a multifaceted intervention strategy based on closed-loop information exchange between proactive and reactive methods: comprehensive as
Trial on control of hypertension by nutritional means: three-year results. (1984)

Ability to safely withdraw medication from well-controlled mild hypertensives was tested in a 3-group randomized trial. Group I (Intervention): drugs were stopped 2 months after nutrition counseling began. Counselling continued throughout the remaining years of the trial to achieve: a minimum of 10 lb weight loss if overweight; reduction of sodium intake to 1800 mg/day or less; reduction of alcohol intake to not more than 2 drinks per day. Group II (control group 1): drugs were stopped to see if previous long-term blood pressure control had a carryover effect without diet change. Pressure was monitored frequently in both groups with return to treatment if diastolic blood pressure rose to 90 mmHg or above. Group III (control group 2) remained on drugs for comparison of blood pressure and biochemical variables. In Group I mean weight loss at 3 years was 7 lb (3.18 kg) with 39% losing 10 lb (4.55 kg) or more; sodium intake was reduced by 37%. Blood pressure control without drugs was achieved in 44% of Group I patients. This compares with only 15% in Group II. These findings suggest it may be possible after establishing good blood pressure control, to maintain control in a sizeable proportion with less or no medication, when reduction of weight, sodium, and alcohol is achieved.
A Comprehensive Review of Lysine-Specific Demethylase 1 and its Roles in Cancer (2017)

Histone methylation plays a key role in the regulation of chromatin structure, and its dynamics regulates important cellular processes. The investigation of the role of alterations in histone methylation in cancer has led to the identification of histone methyltransferases and demethylases as promising novel targets for therapy. Lysine-specific demethylase 1(LSD1, also known as KDM1A) is the first discovered histone lysine demethylase, with the ability to demethylase H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. LSD1 regulates the balance between self-renewal and differentiation of stem cells, and is highly expressed in various cancers, playing an important role in differentiation and self-renewal of tumor cells. In this review, we summarize recent studies about the LSD1, its role in normal and tumor cells, and the potential use of small molecule LSD1 inhibitors in therapy.
Real-time Path Planning for Time-Optimal Helicopter Shipboard Landing via Trajectory Parameterization (2019)

A real-time path planning algorithm is developed to generate time-optimal trajectory for helicopter shipboard landing. The trajectory optimization problem is translated to the lower dimensional flat output space by exploiting the differential flatness property of the simplified helicopter model. Then, the flat outputs are parameterized using piecewise spline functions with adjustable coefficients, which are used to shape the trajectory and approximate the optimal solution. Further, by allowing the flexible selection of each spline segment's time-duration and enforcing additional path constraints, the time-optimality of the planned trajectory is largely preserved without violation of state and input bounds. Compared to pure temporal discretization methods, the proposed algorithm employs considerably less decision variables and significantly reduces the computational time by 75%, which only leads to a 0.5% growth in the optimal flight time as the trade-off. The improvement in computational efficiency enables the real-time recalculation of the time-optimal trajectories on-the-fly if there are unforeseen deviations from the planned flight path.
Study on ferroelectric behaviors and ferroelectric nanodomains of YMnO3 thin film (2014)

Hexagonal YMnO3 is a special kind of multiferroics which shows unique advantages in magneto-electric field due to its low permittivity and only c-axis polarization. However, its ferroelectric properties, especially domain structures, have not been intensively investigated. In this study, YMnO3 film about 270 nm in thickness is prepared on Si(100) substrate by sol-gel spin coating. Structure and morphology of the film are characterized by grazing incidence X-ray diffraction and atomic force microscopy. Domain structure and its reversal behavior on a nanoscale are examined by piezoresponse force microscopy (PFM). The leakage current and ferroelectric property are also investigated. The results show that the film displays a hexagonal perovskite structure with good crystallinity and has smooth surface with a root-mean-square roughness of 7.209 nm. PFM images and typical local piezoresponse loops reveal the good piezoelectric and ferroelectric properties of the YMnO3 film at room temperature. Meanwhile, the offsets of amplitude loop and phase loop are observed due to the internal electric field. Leakage current density of YMnO3 film is lower than 10-6 A·cm-2, so saturated hysteresis loop can be obtained.
Glutamine Starvation Affects Cell Cycle, Oxidative Homeostasis and Metabolism in Colorectal Cancer Cells (2023)

Cancer cells adjust their metabolism to meet energy demands. In particular, glutamine addiction represents a distinctive feature of several types of tumors, including colorectal cancer. In this study, four colorectal cancer cell lines (Caco-2, HCT116, HT29 and SW480) were cultured with or without glutamine. The growth and proliferation rate, colony-forming capacity, apoptosis, cell cycle, redox homeostasis and metabolomic analysis were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (MTT), flow cytometry, high-performance liquid chromatography and gas chromatography/mass spectrometry techniques. The results show that glutamine represents an important metabolite for cell growth and that its deprivation reduces the proliferation of colorectal cancer cells. Glutamine depletion induces cell death and cell cycle arrest in the GO/G1 phase by modulating energy metabolism, the amino acid content and antioxidant defenses. Moreover, the combined glutamine starvation with the glycolysis inhibitor 2-deoxy-D-glucose exerted a stronger cytotoxic effect. This study offers a strong rationale for targeting glutamine metabolism alone or in combination with glucose metabolism to achieve a therapeutic benefit in the treatment of colon cancer.
Precursor of Pro-apoptotic Cytokine Modulates Aminoacylation Activity of tRNA Synthetase (1999)

Endothelial monocyte activating polypeptide II (EMAPII) is a cytokine that is specifically induced by apoptosis. Its precursor (pro-EMAPII) has been suggested to be identical to p43, which is associated with the multi-tRNA synthetase complex. Herein, we have demonstrated that the N-terminal domain of pro-EMAPII interacts with the N-terminal extension of human cytoplasmic arginyl-tRNA synthetase (RRS) using genetic and immunoprecipitation analyses. Aminoacylation activity of RRS was enhanced about 2.5-fold by the interaction with pro-EMAPII but not with its N- or C-terminal domains alone. The N-terminal extension of RRS was not required for enzyme activity but did mediate activity stimulation by pro-EMAPII. Pro-EMAPII reduced the apparent Km of RRS to tRNA, whereas the kcat value remained unchanged. Therefore, the precursor of EMAPII is a multi-functional protein that assists aminoacylation in normal cells and releases the functional cytokine upon apoptosis.
Assessing the level of knowledge and perception among malaysian university students towards covid-19 (2021)

Background: Coronavirus 2019 or CoVid-19 is a new strain of virus from the coronaviridae family which was first detected in Wuhan, China. CoVid-19 has been declared as a world pandemic with approximately 100,000 cases and 14,000 fatalities across 100 countries worldwide. Aim of the Study: The objective of this research is to assess the level of awareness, knowledge, and perception of CoVid-19 among students of university considering the recent outbreak. Methods: A cross-sectional study was conducted. Stratified random sampling was used as respondents were divided into medical and non-medical strata. Questionnaires were distributed to 300 students from 6 different faculties and the results were analyzed. Results: Our results indicated that gender, ethnicity, and type of courses do not hold statistical significance against the knowledge and perception of CoVid-19. There is a significant association though between ethnicity and awareness to CoVid-19 (p = 0.021) and between gender and awareness to CoVid-19 (p = 0.002). Conclusion: The outcome of this study proves our hypothesis that there is no significant association in the level of knowledge and perception towards CoVid-19 between the medical and non-medical students of the university.
Nature's first “atypical opioids”: Kratom and mitragynines (2018)

As debate about the use and abuse potential of kratom swirls, conflicting, often contradicting, opinions are expressed. A review of the basic pharmacology of kratom reveals the explanation for the bifurcation in viewpoints: kratom has both opioid and non-opioid properties. Fascinatingly, just as the poppy plant (Papaver) evolved the typical opioids, Mitragyna evolved the mitragynines-Nature's "atypical opioids."
The role of interferon-gamma on immune and allergic responses (2005)

Allergic diseases have been closely related to Th2 immune responses, which are characterized by high levels of interleukin (IL) IL-4, IL-5, IL-9 and IL-13. These cytokines orchestrate the recruitment and activation of different effector cells, such as eosinophils and mast cells. These cells along with Th2 cytokines are key players on the development of chronic allergic inflammatory disorders, usually characterized by airway hyperresponsiveness, reversible airway obstruction, and airway inflammation. Accumulating evidences have shown that altering cytokine-producing profile of Th2 cells by inducing Th1 responses may be protective against Th2-related diseases such as asthma and allergy. Interferon-gamma (IFN-gamma), the principal Th1 effector cytokine, has shown to be crucial for the resolution of allergic-related immunopathologies. In fact, reduced production of this cytokine has been correlated with severe asthma. In this review, we will discuss the role of IFN-gamma during the generation of immune responses and its influence on allergic inflammation models, emphasizing its biologic properties during the different aspects of allergic responses.
Kinetic analysis of nanoparticle‐protein interactions using a plasmon waveguide resonance (2016)

A plasmon waveguide resonance (PWR) sensor is proposed for studying the interaction between gold nanoparticles and proteins. The ability of the PWR sensor to operate in both TM and TE Polarizations, i.e. its polarization diversity, facilitates the simultaneous spectroscopy of the nanoparticles surface reactions using both polarizations. The response of each polarization to streptavidin-biotin binding at the surface of gold nanoparticles is investigated in real time. Finally, using the principles of multimode spectroscopy, the nanoparticle's surface reactions are decoupled from the bulk solution refractive index variations. Schematic diagram of the NP-modified PWR sensor.
Electron Probe Microanalysis of Cementum and Underlying Dentin in Young Permanent Teeth (1972)

The amount of calcium, phosphorus, and magnesium in human cementum and subjacent dentin of young permanent teeth was studied with the use of an electron probe microanalyzer and was correlated with morphology with the use of a scanning electron microscope. The mineral content of the cementum and the granular layer of Tomes was significantly lower than that of tubular dentin and the hypermineralized zone.
The Photochemical cis–trans Isomerization of Free Stilbene Molecules Follows a Hula‐Twist Pathway (2004)

A motion breaking with tradition: The cis–trans isomerization of nonpolar conjugated π systems does not proceed simply by the 180° twist of a CC bond (“one-bond flip”, OBF), but by the rotation of a central CH group out of the plane (“hula twist”, HT). The hula-twist motion does not require any external constraint but is driven by an internal force: the slope on the way through a conical intersection. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54221_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Using artificial neural network for the calculation of iterated function system codes (1994)

Iterated function system (IFS) is one of the most useful methodologies in fractal transformation. The collage theorem states that image reconstruction as well image compression can be performed using IFS, but the main disadvantage of this algorithm is that it is computationally intensive during extracting suitable attractors to represent the target image. In this paper, an artificial neural network is investigated as an alternative tool for IFS attractors calculation to extract the corresponding image segment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Staples Equal Sutures for Skin Closure After Soft Tissue Tumor Resection (2012)

Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
21S Numerical Analysis of the Effect of Dimples on Flows around a Golf Ball (2001)

Separation flow around a golf ball is numerically simulated using an unstructured grid method. The compressible Navier-Stokes equations are solved by a finite volume cell-vertex upwind scheme with the Lower-Upper Symmetric Gauss-Seidel time-integration method. The golf ball surface with 432 dimples, which is designed by Sumitomo Rubber Industries Ltd., Japan, is modeled more realistically than our previous research by CATIA-CAD and Edge Editor software. The surface is triangulated using the advancing front method. The computational space are discretized by a hybrid unstructured grid where the prismatic cells are used in the wall boundary layers and the tetrahedral cells fill in the remaining region. The computational result shows the essential features of the separated flow around the ball. The irregular flow separations are observed in golf ball dimples. Computed drag coefficient at at Reynolds number of 2×10^5 is as same as the experimental result and our previous work.
Photosensing Resolution of Wireless Communication Chip in Inhomogeneous RF-Magnetic Field (2006)

We have developed a wireless biosensing system for bioluminescence measurements that includes a sensor chip with a volume of 2.5 ×2.5 ×0.5 mm3 and a read/write (R/W) coil. This sensor chip monolithically integrates a photosensor for detecting bioluminescence, a control circuit, and a coil for communication. In order to operate the sensor chip in a sample solution, we employed an RF magnetic field for the transmission of data and electric power between the chip and the R/W unit. The magnitude of the field around the chip changes significantly with the positional relationship between the sensor chip and the R/W coil. Therefore, evaluating the stability of the sensor chip operation, especially the resolution of signal processing, is important. In our system, a resolution of ±30 µV was achieved in an inhomogeneous field ranging from 160 to 379 A/m. We also quantified the adenosine triphosphate (ATP) by measuring bioluminescence to demonstrate the stability of the sensing operation. Although the RF magnetic field fluctuated in the reaction cell where the sensor chip was located, an almost linear relationship between the ATP amount and the sensor response was obtained.
Airway Remodelling in Asthma: From Benchside to Clinical Practice (2010)

Airway remodelling refers to the structural changes that occur in both large and small airways relevant to miscellaneous diseases including asthma. In asthma, airway structural changes include subepithelial fibrosis, increased smooth muscle mass, gland enlargement, neovascularization and epithelial alterations. Although controversial, airway remodelling is commonly attributed to an underlying chronic inflammatory process. These remodelling changes contribute to thickening of airway walls and, consequently, lead to airway narrowing, bronchial hyper-responsiveness, airway edema and mucous hypersecretion. Airway remodelling is associated with poor clinical outcomes among asthmatic patients. Early diagnosis and prevention of airway remodelling has the potential to decrease disease severity, improve control and prevent disease expression. The relationship between structural changes and clinical and functional abnormalities clearly deserves further investigation. The present review briefly describes the characteristic features of airway remodelling observed in asthma, its clinical consequences and relevance for physicians, and its modulation by therapeutic approaches used in the treatment of asthmatic patients.
Timing of oral refeeding in acute pancreatitis: A systematic review and meta‐analysis (2015)

Compared with standard oral refeeding, early oral refeeding safely reduced the length of hospital stay in patients with acute pancreatitis.
Production of a specific antibody against pyruvate kinase type M2 using a synthetic peptide (1988)

The pyruvate kinase isozymes M1 and M2 are structurally and immunologically closely related. To obtain an antibody which discriminates between these two forms, a synthetic tetradecapeptide with a sequence specific for pyruvate kinase type M2 from rats was constructed. Antisera from rabbits, immunized with this peptide, reacted specifically with the M2-type holoenzyme of both rat and human origin, and did not cross-react with the M1-type isozyme. This was established by immunoblot analysis, both under dissociating and non-dissociating conditions.
The Risk of Urinary Tract Infection after Flexible Cystoscopy in Patients with Bladder Tumor Who Did Not Receive Prophylactic Antibiotics (2014)

Antibacterial therapy before outpatient flexible cystoscopy does not appear necessary in patients who have no clinical signs or symptoms of acute urinary tract infection, including bacteriuria.
A planar VHF reconfigurable slot antenna (2002)

This paper presents a novel electronically tunable slot antenna. The design is based on a resonant slot structure loaded with a series of PIN diode switches. The tuning of the operating frequency is realized by varying the electrical length of the antenna, which is controlled by the DC bias voltages of the switches. The fabricated antenna is capable of resonating at four different frequencies ranging from 550 to 900 MHz. Very good matching is achieved for all resonant frequencies without the need for any special matching network. Additionally, it is demonstrated that the radiation pattern, efficiency and polarization remain essentially unaffected by the frequency tuning.
Brazilian Snake Serum and Venom: Studies of the Alternative Pathway and C3 in Man and Serpent (1978)

Abstract It was previously found that antiserum to the anti-complementary protein (CoF) in Naja naja venom cross-reacted with a cobra serum protein with many of the characteristics of C3. Cobra serum but not human C3b inactivator destroyed the activity of CoF. In the present study, the serum and venom of several types of Brazilian snakes were investigated with respect to 1) reactivity with anti-CoF, 2) ability of the venoms to convert human serum C3, 3) ability of the serum to inactivate CoF, and 4) serum alternative pathway activity. The serum, but not the venoms, of Bothrops jararaca, B. jararacussu, B. moogeni, and Crothalus terrificus contained a protein reactive with anti-CoF but failed to destroy the alternative pathway activity of CoF for human serum. The anti-CoF-reactive serum protein in each of the Brazilian snake serums converted to a more cathodal form on incubation of the serum with Escherichia coli 055:B5 endotoxin (ET), CoF, zymosan (Z), and BSA-rabbit anti-BSA-specific precipitates (AgAb) but not on heating at 52°C for 30 min nor incubation with hydrazine. All the venoms produced some conversion of human serum C3 but to a much lesser degree than Naja naja venom. No anaphylatoxin activity could be detected on incubation of snake serum with ET, agar, Z or AgAb.