gebhart/patrepeval huggingface dataset:
A phase I trial of imatinib, hydroxyurea and RAD001 for patients with recurrent malignant glioma (2006)

1580 Background: This study attempts to extend the anti-glioma activity of imatinib mesylate (Gleevec, IM) plus hydroxyurea (H), by adding RAD001 (R), an orally bioavailable inhibitor of mTOR, a critical intracellular mediator of signal transduction and metabolism. Methods: We employ a “3+3” dose escalation design to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of IM + H + R administered daily among adult recurrent malignant glioma patients s with ≤ 3 prior recurrences, KPS &gt; 60% and adequate organ function. Patients are stratified based on concurrent enzyme-inducing anticonvulsant use (EIAC), and both strata are independently escalated. Initial dose level for each stratum: IM - 400 mg/day; H - 500 mg bid; R - 2.5 mg/day. Each treatment cycle is 28 days. Response is evaluated every other cycle. Pharmacokinetic (PK) studies are performed on days 1 and 28 of cycle 1. Results: Twenty-two recurrent GBM patients have enrolled. The median age is 53 (range 37 to 75), 41% are male, and 45% are on EIAC. Two DLTs (grade 4 hypercholesterolemia and thrombocytopenia) occurred among 5 patients on dose level one (non-EIAC stratum). No other DLTs have occurred. The dose escalation schema has been amended to include alternate day R dosing. IM PK were consistent with those previously reported for patients on IM and HU. IM clearance on day 1 was 492 ± 247 ml/min in the EIAC stratum and 231 ± 100 ml/min in the non-EIAC stratum. On day 28, IM clearance was decreased in both strata (243 ± 93 ml/min in the EIAC stratum and 116 ± 47 ml/min in the non-EIAC stratum) PK results for HU and R are pending. Nine patients continue on study having received 2–8 cycles of therapy. Four partial responses have been observed and accrual is ongoing. Conclusions: Further accrual is warranted. An update of outcome, toxicity and pharmacokinetic analyses will be presented. [Table: see text]
A Researcher’s Perspective on Unconventional Lab-to-Fab for 2D Semiconductor Devices (2023)

Current silicon technology is on the verge of reaching its performance limits. This aspect, coupled with the global chip shortage, makes a solid case for steering our attention toward the accelerated commercialization of other electronic materials. Among the available suite of emerging electronic materials, two-dimensional materials, including transition metal dichalcogenides (TMDs), exhibit improved short-channel effects, high electron mobility, and integration into CMOS-compatible processing. While these materials may not be able to replace silicon at the current stages of development, they can supplement Si in the form of Si-compatible CMOS processing and be manufactured for tailored applications. However, the major hurdle in the path of commercialization of such materials is the difficulty in producing their wafer-scale forms, which are not necessarily single crystalline but on a large scale. Recent but exploratory interest in 2D materials from industries, such as TSMC, necessitates an in-depth analysis of their commercialization potential based on trends and progress in entrenched electronic materials (Si) and ones with a short-term commercialization potential (GaN, GaAs). We also explore the possibility of unconventional fabrication techniques, such as printing, for 2D materials becoming more mainstream and being adopted by industries in the future. In this Perspective, we discuss aspects to optimize cost, time, thermal budget, and a general pathway for 2D materials to achieve similar milestones, with an emphasis on TMDs. Beyond synthesis, we propose a lab-to-fab workflow based on recent advances that can operate on a low budget with a mainstream full-scale Si fabrication unit.
Pediatric Epilepsy Case Studies (2008)

The Basics A Pediatric Epilepsy Primer, J.W. Owens, M.D., Ph.D. Developmental Pharmacokinetics: Principles and Practice, G.D. Anderson, Ph.D. and J.M. Rho, M.D. Dietary Therapies for Epilepsy, E.H. Kossoff, M.D. Vagus Nerve Stimulation Therapy, J.W. Wheless, M.D. Epilepsy Surgery in Children, T. Loddenkemper, M.D. Status Epilepticus, J.J. Riviello, Jr., M.D. The Neonate Benign Familial Neonatal Seizures, E. Marsh, M.D., Ph.D. and E.C. Cooper, M.D., Ph.D. Hypoxic-Ischemic Encephalopathy (Neonatal Seizures), M.S. Scher, M.D. Ohtahara Syndrome, W.D. Shields, M.D. The Infant Febrile Seizures, J.R. Buchhalter, M.D., Ph.D. Generalized Epilepsy with Febrile Seizures Plus (GEFS+), N. Baker, M.D. Benign Myoclonic Epilepsy of Infancy, K.L. Park, M.D. and D.R. Nordli, Jr., M.D. Severe Myoclonic Epilepsy in Infancy, M.M. Troester, D.O. Infantile Spasms, R.A. Hrachovy, M.D. and J.D. Frost, Jr., M.D. Gelastic Seizures, Y.-t. Ng, M.D., FRACP Tuberous Sclerosis Complex, A.F. Luat, M.D. and H.T. Chugani, M.D. Herpes Simplex Encephalitis, D.F. Clarke, M.D. Refractory Status Epilepticus, J.J. Riviello, Jr., M.D. Myoclonus Epilepsy with Ragged Red Fibers, R.P. Saneto, D.O., Ph.D. Sturge-Weber Syndrome, A.K. Tripathy, M.D. and A. Gupta, M.D. The Child Benign Epilepsy of Childhood with Central-Temporal Spikes, P.M. Levisohn, M.D. Childhood Absence Epilepsy, L.M. Frank, M.D. Panayiotopoulos Syndrome, K. Williams, M.D., Ph.D. Complex Partial Seizures, A.A. Wilfong, M.D. Lennox-Gastaut Syndrome, J.M. Rho, M.D. Nonconvulsive Status Epilepticus, J.J. Riviello, Jr., M.D. Focal Cortical Dysplasia, S. Koh, M.D. Landau-Kleffner Syndrome, J.F. Kerrigan, M.D. Continuous Spike-and-Wave Activity during Slow-Wave Sleep, K. Chapman, M.D. Rasmussen Encephalitis, D.H. Arndt, M.D. and R. Sankar, M.D., Ph.D. Myoclonic-Astatic Epilepsy, A.G. Christina Bergqvist, M.D. The Adolescent Juvenile Myoclonic Epilepsy, C. Drees, M.D. Epilepsy in Adolescent Females, M.L. Zupanc, M.D. Unverricht-Lundborg Disease, D.M. Andrade, M.D.,M.Sc. and B.A. Minassian, C.M., FRCP(C) Post-Traumatic Seizures and Epilepsy, D.H. Arndt, M.D. and C.C. Giza, M.D. Reflex Epilepsy, M.C. Kruer, M.D. and C.M. Roberts, M.D. Autosomal Dominant Nocturnal Frontal Lobe Epilepsy, K. Chapman, M.D. Index
Direct Growth of Highly Strained Pt Islands on Branched Ni Nanoparticles for Improved Hydrogen Evolution Reaction Activity (2019)

The direct growth of Pt islands on lattice mismatched Ni nanoparticles is a major synthetic challenge and a promising strategy to create highly strained Pt atoms for electrocatalysis. By using very mild reaction conditions, Pt islands with tunable strain were formed directly on Ni branched particles. The highly strained 1.9 nm Pt-island on branched Ni nanoparticles exhibited high specific activity and the highest mass activity for hydrogen evolution (HER) in a pH 13 electrolyte. These results show the ability to synthetically tune the size of the Pt islands to control the strain to give higher HER activity.
LLC Resonant Converter With Topology Morphing Rectifier for Wide Output Voltage Range Application (2018)

LLC is one of the most popular DC/DC converters in electric vehicle chargers, however, the change of state of charge requires output voltage range as wider as nearly four times between the upper and lower limits, and always forces the switching frequency to swing outside the preference region. Based on LLC resonant converter, a novel topology morphing rectifier, which can be operated either as full bridge rectifier or as voltage doubler rectifier, is proposed in this paper. This rectifier offers a cost and controllability competitive alternate for wide output voltage range applications. The average efficiency of prototype converter was measured to be more than 95% at a peak power of 0.5 kW, and furthermore the output voltage from 50V to 200V verified the concept of topology morphing.
Long-Chain Omega-3 Oils–An Update on Sustainable Sources (2010)

Seafood is currently the best and generally a safe source of long-chain (LC, (≥C(20)) omega-3 oils amongst the common food groups. LC omega-3 oils are also obtained in lower amounts per serve from red meat, egg and selected other foods. As global population increases the opportunities to increase seafood harvest are limited, therefore new alternate sources are required. Emerging sources include microalgae and under-utilized resources such as Southern Ocean krill. Prospects for new land plant sources of these unique and health-benefiting oils are also particularly promising, offering hope for alternate and sustainable supplies of these key oils, with resulting health, social, economic and environmental benefits.
APPLICATION OF A RESISTANCE MOISTURE METER TO HVI STRENGTH MEASUREMENTS (1998)

A series of four studies were conducted with the assistance of two U.S. Department of Agriculture AgriculturalMarketing Service offices to determine the range of fiber moisture encountered in cotton classing and to examine thepotential of using on-line moisture readings to assist with fiber strength readings. These studies showed that the metercould be used with the existing high volume instrument (HVI) cotton classing equipment and that the measured moisturecontent (m.c.) correlated with the HVI strength, as it should. The first study, conducted at the Memphis Quality ControlSection, demonstrated the usefulness of the resistance moisture meter and showed a strong relationship between measuredm.c. and HVI strength. The second study was conducted at the Greenwood, Mississippi, Classing Office (CO) during theregular classing season to determine if the meter could operate under CO production conditions and determine the rangeof moisture contents which must be measured. The meter functioned well during the classing season. The measured m.c. ofcotton samples was found to have a greater range than expected during classing and was directly proportional to the HVIstrength. Ninety-four percent of the samples were within the range of 6.3% to 7.6% wet basis (w.b.) but the entire observedrange was 5.8% to 10.0% w.b. The third study was conducted at the Greenwood CO on samples prepared at the U.S.Cotton Ginning Laboratory, USDA, ARS, Stoneville, Mississippi, and ginned under several moisture treatments. Ginningmachines and post-ginning moisture treatment affected the fiber m.c. relatively little, but a significant reduction instrength was attributed to ginning at m.c. below 7% w.b. The fourth study was conducted at the Greenwood CO wheresamples were subjected to nonstandard moisture conditions and then HVI classed. This study showed that even when them.c. variation measured by the experimental meter was low (0.3% w.b.) there was a measurable effect on HVI strength.All four studies resulted in a significant correlation between the measured m.c. and the measured HVI strength showingthat the resistance moisture meter is a promising addition to the HVI classing line.
Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure (2022)

Although they were significantly younger, patients with BAV who had isolated severe AS had worse preoperative LV function and an increased risk of postoperative heart failure hospitalization compared with patients who had TAV. Our findings suggest that patients who have BAV with AS might benefit from closer surveillance and possibly earlier intervention.
WLC38-5: Multi-Antenna Limited Feedback for Temporally-Correlated Channels: Feedback Compression (2006)

A novel method is proposed for reducing the feedback rate of a transmit beamforming system with feedback of quantized channel state information. Specifically, the channel is modeled as a Markov chain and the feedback bits are compressed by truncating the Markov chain transition probabilities. Using the proposed method, the feedback rate can be compressed by more than 100% without degrading the system performance.
Piezo shunt power flow optimization for composite beam stabilization (2008)

Numerical and technological tools have been developed for complete electromechanical integration of innovative shunting damping strategies for piezoelectric composite beam stabilization to realize a new type of hybrid piezo-composite smart structure. The approach enhances the performance of fully passive configurations to control mechanical power flow in a beam by using negative capacitance elements. In contrast to passive shunted components that target discrete modes, negative capacitance shunted piezoelectric transducers offer the potential for broadband control from the low Hertz into the kilohertz range. This paper presents an original approach to tune vibration power flow dispersion in a piezocomposite beam to obtain total wave absorption by only optimizing the electrical circuit configuration shunting a single piezopatch. The numerical study considers the power flow efficiency of the strategy and the stability and robustness difficulties observed when a single device is considered. The simplicity of the proposed electromechanical controlling device affords the possibility to define and realize distributed configurations and also lends itself to integrated distributed smart composite structures.
Menstrual cyclic thrombocytopenia (1989)

We studied three patients with cyclic thrombocytopenia which occurred in phase with the menstrual cycle. The platelet count in each patient reached a nadir of 5-20 x 10(9)/l at the onset of menses. Thrombocytopenia was associated with bruising, epistaxis and menorrhagia and was followed 5-14 d later by normal or elevated platelet counts (up to 900 x 10(9)/l). Repeat bone marrow examinations performed at the time of reduced platelet counts showed megakaryocytic hyperplasia. 111In-platelet-disappearance from the circulation was measured in one patient; T50, time to half activity, was shortened to 0.7 d during the period of thrombocytopenia and was prolonged to 3.2 d when the platelet count increased (normal platelet T50 is about 4.8 d). In two of three patients platelet-associated anti-glycoprotein Ib autoantibodies were present and remained elevated despite normalization of the platelet count. In both of two patients the decrease in platelet count at the onset of menses was associated with an increase in the expression of monocyte Fc gamma receptors. Based on the reported capacity of oestrogenic hormones to modulate macrophage Fc gamma receptor expression, we propose that hormonal changes during the menstrual cycle may alter the Fc gamma receptor-mediated clearance of antibody-coated platelets by macrophages, modulate platelet survival, and cause cyclic thrombocytopenia.
Numerical Analysis of Design Parameters for a Generic Fan-in-Wing Configuration (2009)

Abstract The present investigation focuses on the study of design parameters for a generic fan-in-wing configuration. The objective is to evaluate the performance of a fan-in-wing concept in a Short-Take-Off and Landing situation. The results presented are also of interest for transition between hover and a wing-sustained flight for a Vertical Take Off and Landing concept. Steady Reynolds Averaged Navier–Stokes computations using an actuator disk technique are performed. The results show a good agreement with experimental data and simulation results obtained in previous investigations for a generic wind tunnel model. A parametric study is conducted for a more realistic wing planform. For a single fan installed in the wing, the streamwise and spanwise influence on the wing aerodynamics is studied. In addition, the effect of the fan diameter and the fan rotation axis inclination is analyzed. For all variations, a discussion concerning the induced lift due to the jet flap effect is given. A fan installed in the wing improves significantly the lift coefficient but reduces considerably the wing efficiency in terms of lift-over-drag ratio. At high jet speeds, the jet has the tendency to roll up in a pair of counter rotating vortices on a preferred side depending on the fan spanwise position and the angle of attack. On this preferred side, one vortex is dominant in the pair. This study highlights other critical parameters with possible benefits on the wing performance.
Vertical profiles of environmental parameters measured from physical, optical and imaging sensors during station TARA_005 of the Tara Oceans expedition 2009-2013 (2014)

The Tara Oceans Expedition (2009-2013) sampled the world oceans on board a 36 m long schooner, collecting environmental data and organisms from viruses to planktonic metazoans for later analyses using modern sequencing and state-of-the-art imaging technologies. Tara Oceans Data are particularly suited to study the genetic, morphological and functional diversity of plankton. The present data set includes properties of seawater, particulate matter and dissolved matter from physical, optical and imaging sensors mounted on a vertical sampling system (Rosette) used during the 2009-2013 tara Oceans Expedition. It comprised 2 pairs of conductivity and temperature sensors (SEABIRD components), and a complete set of WEtLabs optical sensors, including chrorophyll and CDOM fluorometers, a 25 cm transmissiometer, and a one-wavelength backscatter meter. In addition, a SATLANTIC ISUS nitrate sensor and a Hydroptic Underwater Vision Profiler (UVP) were mounted on the rosette. In the Arctic Ocean and Arctic Seas (2013), a second oxygen sensor (SBE43) and a four frequency Aquascat acoustic profiler were added. The system was powered on specific Li-Ion batteries and data were self-recorded at 24HZ. Sensors have all been factory calibrated before, during and after the four year program. Oxygen was validated using climatologies (WOA09). Nitrate and Fluorescence data were adjusted with discrete measurements from Niskin bottles mounted on the Rosette, and optical darks were performed monthly on board. A total of 839 quality checked vertical profiles were made during the tara Oceans expedition 2009-2013.
Classification of landmine-like metal targets using wideband electromagnetic induction (1999)

Our previous work has indicated that the careful application of signal detection theory can dramatically improve detectability of landmines using time-domain electromagnetic induction (EMI) data. In this paper, classification of various metal targets via signal detection theory is investigated using a prototype wideband frequency-domain EMI sensor. An algorithm that incorporates both the uncertainties regarding the target-sensor orientation and a theoretical model of the response of such a sensor is developed. The performance of this approach is evaluated using both simulated and experimental data. The results show that this approach affords substantial classification performance gains over the traditional matched filter approach, on average by 60%.
Acceleration of Landweber-type algorithms by suppression of projection on the maximum singular vector (2002)

A procedure is developed that speeds up the convergence during the initial stage (the first 100 forward and backward projections) of Landweber-type algorithms for iterative image reconstruction, which include the Landweber, generalized Landweber, and steepest descent algorithms. In this procedure, the singular vector associated with the maximum singular value of the PET (positron emission tomography) system matrix is identified, and then projection of the data on this singular vector is suppressed after a single Landweber iteration. Typical PET system matrices have a significant gap between their two largest singular values; hence this suppression allows larger gains in subsequent iterations, speeding up convergence by roughly a factor of three. The present work includes: (1) a study of the singular value spectra of typical PET system matrices; (2) a study of the effect on convergence of projection on the maximum singular vector; and (3) a study of the convergence behavior of the procedure applied to the Landweber, generalized Landweber, steepest descent, conjugate gradient, and algebraic reconstruction technique algorithms. A comparison is made with the maximum-likelihood expectation-maximization algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A gene encoding a chloroplast omega-3 fatty acid desaturase complements alterations in fatty acid desaturation and chloroplast copy number of the fad7 mutant of Arabidopsis thaliana. (1993)

Mutations at the fad7 locus of Arabidopsis thaliana (previously called fadD) cause decreased desaturation of dienoic fatty acids in chloroplast lipids in plants grown at elevated temperatures. This suggested that the fad7 locus encodes a chloroplast omega-3 desaturase that catalyzes the desaturation of lipid-linked 18:2 and 16:2 fatty acids. In order to clone the fad7 gene, it was first genetically mapped relative to the flanking restriction fragment length polymorphism markers 4547 and 2488A on chromosome 3, and yeast artificial chromosomes covering the locus were identified. A putative desaturase cDNA clone that was isolated by low stringency heterologous probing with a cDNA for an endoplasmic reticulum-localized omega-3 desaturase (fad3) hybridized to the yeast artificial chromosomes and could not be resolved from the locus by restriction fragment length polymorphism mapping. Expression of the cDNA in transgenic fad7 mutant plants resulted in restoration of wild type fatty acid composition and suppression of a previously observed effect of the fad7 mutation on chloroplast number, indicating genetic complementation. The structural gene contained seven introns within a coding sequence of 1338 base pairs, which encodes a 446-amino acid polypeptide of 51,172 daltons. The amino-terminal region of the fad7 gene product contained a consensus chloroplast transit peptide. Except for the amino-terminal domain, the deduced amino acid sequence of the fad7 gene product had high homology to the fad3 gene product, indicating that fad7 encodes an omega-3 desaturase and that the two genes arose from a common ancestral gene. There was no apparent effect of growth temperature on the steady-state levels of fad7 mRNA in wild type plants.
Defective propeptide processing and abnormal activation underlie the molecular pathology of factor IX Troed‐y‐Rhiw (1989)

Affected members of a South Wales haemophilia B family (from Troed-y-Rhiw) were shown by Western blotting and immunoperoxidase detection to have a factor IX molecule of higher than normal molecular weight which also shows impaired calcium binding. Gene cloning and DNA sequencing revealed the same arginine to glutamine mutation at position -4 of the propeptide that has been found in two previously described factor IX variants which circulate with the propeptide still attached. The mutation also abolishes a HaeIII restriction enzyme recognition site. A potential carrier was shown to be normal both by Western blotting and DNA studies. The way in which the attached propeptide interferes with normal factor IX function was investigated by activation studies with crude normal and patient factor IX Troed-y-Rhiw preparations using Western blotting and detection with iodinated immunopurified polyclonal antifactor IX serum. We demonstrate that the -4 mutation appears to block cleavage between the Arg145-Ala146 peptide bond in the activation peptide, thus preventing the normal activation of factor IX Troed-y-Rhiw. A small amount of normally processed factor IX is produced, implying that the -4 mutation does not completely prevent propeptide cleavage, thus accounting for the low levels of factor IX activity measured in the plasma of affected family members.