gebhart/patrepeval huggingface dataset:
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer (2014)

We have developed functional assays that characterize aminopeptidase activities in urine specimens with adequate technical and intraindividual reproducibility. With further testing, it could yield a reliable biomarker test for bladder cancer detection or prognostication.
Endovascular embolization of arteriovenous malformations by bi-directional injection of a biocompatible two component polymer (2003)

Preliminary studies strongly suggest that biocompatible and mechanically stable embolizing two component polymers can be selectively delivered to cerebral arteriovenous malformations (AVMs) using a bi-directional endovascular injection technique. A computer model and two vascular graft models have been developed to simulate the proposed injection from positions both proximal and distal to the AVM. The current project further developed and optimized the bi-directional injection technique and evaluated the long-term properties of the embolization polymer. Tissue reactivity and endovascular biocompatibility of the liquid and solid forms of the polymer injectate, as well as the mechanical response of the polymer plug were tested in vivo. The polymer tests helped confirm that the current polymer candidate calcium alginate, (sodium alginate reacted with calcium chloride to form calcium alginate) is a safe, stable, and biocompatible material. Purified sodium alginate polymer, with a high guluronic acid content, has the potential to form a mechanically stable and biocompatible endovascular plug.
Solvothermal synthesis: a new route for preparing nitrides (2002)

Solvothermal synthesis appears to be an interesting route for preparing nitrides such as gallium nitride and aluminium nitride, using ammonia as solvent. A nitriding additive is used to perform the reaction and, in the case of gallium nitride, is encapsulated by melt gallium. The syntheses are performed in the temperature range 400-800°C and in the pressure range 100-200 MPa. The synthesized powders are characterized by x-ray diffraction and scanning electron microscopy. Finely divided gallium nitride GaN and aluminium nitride AlN, both with wurtzite-type structure, can be obtained by this route.
Pseudorapidity distributions of charged hadrons in proton-lead collisions at s N N = 5.02 $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ and 8.16 TeV (2018)

The pseudorapidity distributions of charged hadrons in proton-lead collisions at nucleon-nucleon center-of-mass energies s NN = 5.02 and 8.16 TeV are presented. The measurements are based on data samples collected by the CMS experiment at the LHC. The number of primary charged hadrons produced in non-single-diffractive protonlead collisions is determined in the pseudorapidity range | lab | < 2.4. The chargedhadron multiplicity distributions are compared to the predictions from theoretical calculations and Monte Carlo event generators. In the center-of-mass pseudorapidity range | cm | < 0.5, the average charged-hadron multiplicity densities dN ch /d cm |cm| < 0.5 are 17.31 0.01 (stat) 0.59 (syst) and 20.10 0.01 (stat) 0.85(syst) at s NN = 5.02 and 8.16 TeV, respectively. The particle densities per participant nucleon are compared to similar measurements in proton-proton, proton-nucleus, and nucleus-nucleus collisions.
Microservice architecture in industrial software delivery on edge devices (2018)

Production in Industry 4.0 calls for flexible configurations, customizable features, frequent changes, and above all, short time to market, which poses significant challenges to the practices of industrial software development and delivery. However, under strict regulations and non-negotiable requirements on safety, reliability and compliance, industrial software is still dominated by monolithic architecture that usually requires planned downtime and manual installation for each update. The result is a typical release cycle of 12-18 months with several patches during the release cycle.
Targeting of G Protein-coupled Receptors to the Basolateral Surface of Polarized Renal Epithelial Cells Involves Multiple, Non-contiguous Structural Signals (1998)

Truncations and chimeras of the alpha2A-adrenergic receptor (alpha2AAR) were evaluated to identify membrane domains responsible for its direct basolateral targeting in Madin-Darby canine kidney cells. An alpha2AAR truncation, encoding transmembrane (TM) regions 1-5, was first delivered basolaterally, but within minutes appeared apically, and at steady-state was primarily lateral in its immunocytochemical localization. A TM 1-5 truncation with the third intracellular loop revealed more intense lateral localization than for the TM 1-5 structure, consistent with the role of the third intracellular loop in alpha2AAR stabilization. Addition of TM 6-7 of A1 adenosine receptor (A1AdoR) to alpha2AARTM1-5 creates a chimera, alpha2AARTM1-5/A1AdoRTM6-7, which was first delivered apically, resulting either from loss of alpha2AAR sorting information in TM 6-7 or acquisition of apical trafficking signals within A1AdoRTM6-7. Evidence that alpha2AARTM6-7 imparts basolateral targeting information is revealed by the significant basolateral localization of the A1AdoRTM1-5/alpha2AARTM6-7 and A1AdoRTM1-5/alpha2AARTM6-7+i3 chimeras, in contrast to the dominant apical localization of A1AdoR. These results reveal that sequences within TM 1-5 and within TM 6-7 of the alpha2AAR confer basolateral targeting, providing the first evidence that alpha2AAR basolateral localization is not conferred by a single region but by non-contiguous membrane-embedded or proximal sequences.
DSA‐Mesh: a distributed security architecture for wireless mesh networks (2010)

Abstract Wireless Mesh Networks (WMNs) have emerged recently as a technology for next‐generation wireless networking. They consist of mesh routers and clients, where mesh routers are almost static and form the backbone of WMNs. WMNs provide network access for both mesh and conventional clients. In this paper, we propose DSA‐Mesh, a fully distributed security architecture that provides access control for mesh routers as well as a key distribution scheme that supports layer‐2 encryption to ensure security and data confidentiality of all communications that occur in the backbone of the WMN. DSA‐Mesh exploits the routing capabilities of mesh routers: after connecting to the access network as generic wireless clients, new mesh routers authenticate to a key management service (consisting of several servers) implemented using threshold cryptography, and obtain a temporary key that is used both to prove their credentials to neighbor nodes and to encrypt all the traffic transmitted on wireless backbone links. A key feature in the design of DSA‐Mesh is its independence from the underlying wireless technology used by network nodes to form the backbone. Furthermore, DSA‐Mesh enables seamless mobility of mesh routers. Since it is completely distributed, DSA‐Mesh permits to deploy automatically and incrementally large WMNs, while increasing, at the same time, the robustness of the system by eliminating the single point of failure typical of centralized architectures. DSA‐Mesh has been implemented in Network Simulator, and extensive simulations have been performed in large‐scale network scenarios, comparing it to a static key approach and to a centralized architecture where a single key server is deployed. Numerical results show that our proposed architecture considerably increases the WMN security and reliability, with a negligible impact on the network performance, thus representing an effective solution for wireless mesh networking. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Proposed Voltage Vector to Optimize Efficiency of Direct Torque Control (2014)

Compared to field-oriented control (FOC) system, direct torque control (DTC) system has gained attractiveness in control drive system because of its simpler control structure and faster dynamic control. However, supplying the drive system with rated flux at light load will decrease the power factor and efficiency of the system. Thus, an optimal flux has been applied during steady-state in order to maximize the efficiency of drive system. But when a torque is suddenly needed, for example during acceleration, the dynamic of the torque response would be degraded and it is not suitable for electric vehicle (EV) applications. Therefore, a modification to the voltage vector as well as look-up table has been proposed in order to improve the performance of torque response.
Training model for microvessel anastomosis (1994)

In the early stages of microsurgical training a model is required which is accessible, inexpensive, and approximates human tissue. In this research centre initial training exercises utilize cold stored vessels harvested from sacrificed animals used in other experiments. This model serves as an initial training tool prior to the progression to live animal research which maximizes use of animal specimens and approximates the in vivo qualities of blood vessels. The costs involved are minimal and a large number of vessels can be efficiently harvested and stored using basic equipment. As a training model, cold stored vessels have balanced cost with practicality, given an excellent approximation to living tissue and have markedly reduced our usage of live animals for teaching. This latter effect is significant at a time of increased scrutiny of the ethical use of laboratory animals.
The Forward Look In Architect's Abbey (1960)

From the Rice Thresher Archive, a collection of newspaper articles published in the student newspaper for Rice University. Genre: News
Back Cover: Synthesis of Hybrid Electroactive Materials by Low‐Potential Electropolymerization of Gold Nanoparticles Capped with Tailored EDOT‐Thiophene Precursor Units (ChemElectroChem 8/2014) (2014)

On p. 1312, A. Yassin et al. show how electrochemical polymerization of gold nanoparticles decorated with a tailored thiophene-3,4-ethylenedioxythiophene precursor leads to a homogeneous well-defined electroactive hybrid material.
Towards a Saturated Molecular Genetic Linkage Map for Cultivated Sunflower (2003)

The density and utility of the molecular genetic linkage map of cultivated sunflower ( Helianthus annuus L.) has been greatly increased by the development and mapping of several hundred simple sequence repeat (SSR) markers. Of 1089 public SSR markers described thus far, 408 have been mapped in a recombinant inbred line (RIL) mapping population (RHA280 × RHA801). The goal of the present research was to increase the density of the sunflower map by constructing a new RIL map (PHA × PHB) based on SSRs, adding loci for newly developed SSR markers to the RHA280 × RHA801 RIL map, and integrating the restriction fragment length polymorphism (RFLP) and SSR maps of sunflower. The latter was accomplished by adding 120 SSR marker loci to a backbone of 80 RFLP marker loci on the HA370 × HA372 F 2 map. The map spanned 1275.4 centimorgans (cM) and had a mean density of 6.3 cM per locus. The PHA × PHB SSR map was constructed from 264 SSR marker loci, spanned 1199.4 cM, and had a mean density of 4.5 cM per locus. The RHA280 × RHA801 map was constructed by adding 118 new SSR and insertion–deletion (INDEL) marker loci to 459 previously mapped SSR marker loci. The 577‐locus map spanned 1423.0 cM and had a mean density of 2.5 cM per locus. The three maps were constructed from 1044 DNA marker loci (701 unique SSR and 89 unique RFLP or INDEL marker loci) and supply a dense genome‐wide framework of sequence‐based DNA markers for molecular breeding and genomics research in sunflower.
Trogocytosis of peptide–MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils (2017)

Th2 immunity plays important roles in both protective and allergic responses. Nevertheless, the nature of antigen-presenting cells responsible for Th2 cell differentiation remains ill-defined compared with the nature of the cells responsible for Th1 and Th17 cell differentiation. Basophils have attracted attention as a producer of Th2-inducing cytokine IL-4, whereas their MHC class II (MHC-II) expression and function as antigen-presenting cells are matters of considerable controversy. Here we revisited the MHC-II expression on basophils and explored its functional relevance in Th2 cell differentiation. Basophils generated in vitro from bone marrow cells in culture with IL-3 plus GM-CSF displayed MHC-II on the cell surface, whereas those generated in culture with IL-3 alone did not. Of note, these MHC-II-expressing basophils showed little or no transcription of the corresponding MHC-II gene. The GM-CSF addition to culture expanded dendritic cells (DCs) other than basophils. Coculture of basophils and DCs revealed that basophils acquired peptide-MHC-II complexes from DCs via cell contact-dependent trogocytosis. The acquired complexes, together with CD86, enabled basophils to stimulate peptide-specific T cells, leading to their proliferation and IL-4 production, indicating that basophils can function as antigen-presenting cells for Th2 cell differentiation. Transfer of MHC-II from DCs to basophils was also detected in draining lymph nodes of mice with atopic dermatitis-like skin inflammation. Thus, the present study defined the mechanism by which basophils display MHC-II on the cell surface and appears to reconcile some discrepancies observed in previous studies.
Changes in Upper Extremity Position Cause Migration of Peripherally Inserted Central Catheters in Neonates (2002)

Arm movements significantly affect the position of the tip of the PICCs. Prevention of catheter migration into the right atrium requires radiographic determination of vein of insertion and monitoring of catheter tip position with upper extremity in position of maximum inward movement of catheter for that vein. Arm movements can be used to correct the malpositioned catheters.
Epithelial Integrins with Special Reference to Oral Epithelia (2011)

Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.
A review of bloat in feedlot cattle. (1998)

Improvements in feedlot management practices and the use of various feed additives have reduced, but not eliminated, the occurrence of bloat in feedlot cattle. Feedlot bloat reduces the profitability of production by compromising animal performance and more directly by causing fatalities. In feedlots, bloat is associated with the ingestion of large amounts of rapidly fermented cereal grain and destabilization of the microbial populations of the rumen. An abundance of rapidly fermented carbohydrate allows acid-tolerant bacteria (e.g., Streptococcus bovis and Lactobacillus spp.) to proliferate and produce excessive quantities of fermentation acids. As a result, ruminal pH becomes exceedingly low, and this impairs rumen motility. Further, the excessive production of mucopolysaccharide or "slime" increases the viscosity of ruminal fluid and stabilizes the foam implicated in frothy feedlot bloat. Although protocols have been developed to treat feedlot bloat, the most profitable approach is to use management strategies to reduce its likelihood. Amount of roughage, grain processing techniques, selection of cereal grain (e.g., corn, barley, and wheat), dietary adaptation periods, and various additives (e.g., ionophores) can influence the occurrence of bloat in feedlot cattle. Successful management of these factors depends on a thorough understanding of the behavioral, dietary, and microbial events that precipitate bloat in feedlot cattle.
Moonlighting in drug metabolism (2020)

Drug metabolizing enzymes catalyze the biotransformation of many of drugs and chemicals. The drug metabolizing enzymes are distributed among several evolutionary families and catalyze a range of detoxication reactions, including oxidation/reduction, conjugative, and hydrolytic reactions that serve to detoxify potentially toxic compounds. This detoxication function requires that drug metabolizing enzymes exhibit substrate promiscuity. In addition to their catalytic functions, many drug metabolizing enzymes possess functions unrelated to or in addition to catalysis. Such proteins are termed 'moonlighting proteins' and are defined as proteins with multiple biochemical or biophysical functions that reside in a single protein. This review discusses the diverse moonlighting functions of drug metabolizing enzymes and the roles they play in physiological functions relating to reproduction, vision, cell signaling, cancer, and transport. Further research will likely reveal new examples of moonlighting functions of drug metabolizing enzymes.
Reliability analysis on ductus venosus assessment at 11–14 weeks' gestation in a high‐risk population (2007)

Interobserver reliability for EDV is only moderate, whereas for the PIV is substantial, allowing its use for clinical purposes in a high-risk population.
Embryonic Staging System for the Black Mastiff Bat, Molossus rufus (Molossidae), Correlated With Structure‐Function Relationships in the Adult (2008)

An embryonic staging system for Molossus rufus (also widely known as Molossus ater) was devised using 17 reference specimens obtained during the postimplantation period of pregnancy from wild-caught, captive-bred females. This was done in part by comparing the embryos to a developmental staging system that had been created for another, relatively unrelated bat, Carollia perspicillata (family Phyllostomidae). Particular attention was paid to the development of species-specific features, such as wing and ear morphology, and these are discussed in light of the adaptive significance of these structures in the adult. M. rufus can be maintained and bred in captivity and is relatively abundant in the wild. This embryonic staging system will facilitate further developmental studies of M. rufus, a model species for one of the largest and most successful chiropteran families, the Molossidae.
Trials of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide (1991)

T lymphocytes which mediate several experimental autoimmune diseases, including encephalomyelitis (EAE) and uveoretinitis (EAU) in Lewis rats, preferentially utilize V beta 8 gene product in their receptor. Vaccination against a V beta 8.2-derived peptide was reported to inhibit EAE induction and we report here on the effect of vaccination with this peptide on the development of EAU. Experimental rats were pretreated with the V beta 8.2 peptide, emulsified in adjuvant (CFA), whereas control animals were untreated or injected with saline in CFA. Rats of all groups were immunized 30 or 40 days later with the immunopathogenic antigen, emulsified in Mycobacterium-enriched CFA. Vaccination with CFA emulsions containing either the V beta 8.2 peptide or saline, remarkably inhibited the development of the tested diseases, as compared to the untreated controls. Vaccination with the V beta 8.2 peptide had variable effects in this study on disease development: it inhibited the S-antigen-induced EAU more than did treatment with CFA in four out of six experiments, had a similar effect to that of CFA in one experiment and enhanced the disease in another experiment. Conversely, vaccination with the V beta 8.2 peptide slightly enhanced the EAU induced by the interphotoreceptor retinoid-binding protein (IRBP), or its dominant determinant, in three of four experiments and had no apparent effect in the fourth experiment. In addition, we could not reproduce the reported protective effect of vaccination with the V beta 8.2 peptide against induction of EAE. Vaccination with the V beta 8.2 peptide also had no clear effect on the development of humoral or cellular immune responses against S-antigen.(ABSTRACT TRUNCATED AT 250 WORDS)
Behavior of the Wasserstein distance between the empirical and the\n marginal distributions of stationary $\\alpha$-dependent sequences (2015)

We study the Wasserstein distance of order 1 between the empirical\ndistribution and the marginal distribution of stationary $\\alpha$-dependent\nsequences. We prove some moments inequalities of order p for any p $\\ge$ 1, and\nwe give some conditions under which the central limit theorem holds. We apply\nour results to unbounded functions of expanding maps of the interval with a\nneutral fixed point at zero. The moment inequalities for the Wasserstein\ndistance are similar to the well known von Bahr-Esseen or Rosenthal bounds for\npartial sums, and seem to be new even in the case of independent and\nidentically distributed random variables.\n
Computer-Aided Structural Engineering (CASE) Project. User's Guide: Pile Group Analysis (CPGA) Computer Program (1989)

Abstract : A computer program for basic pile group analysis, CPGA, was developed through the Computer-Aided Structural Engineering (CASE) Project by the Task Group on Pile Structures and Substructures. It is intended to be a simple program for pile group analysis to eliminate many of the inaccuracies inherent in hand analysis methods. The program assumes the pile cap to be rigid and the piles to be linearly elastic. Soil resistance to pile movement may be included. This technical report includes material as a user's manual in Part I and theoretical and background material in Part II.
Visualizing punctuation restoration in speech transcripts with prosograph (2018)

We have developed a neural architecture that tests the effect of lexical, morphosyntactic and prosodic features in restoring punctuation in speech transcriptions. Having outperformed a baseline model in terms of precision and recall, we further extend our performance tests by attaching it in a speech recognition pipeline. The visual and interactive testing environment that we prepared helps us observe how our models generalizes in unseen data and also plan our next steps for improvement.