gebhart/patrepeval huggingface dataset:
Fatty Acids and Their Derivatives as Modulators of Appressorium Formation inMagnaporthe grisea (1999)

Appressorium formation in germinating conidia of Magnaporthe grisea was inhibited on inductive and on noninductive surfaces by monounsaturated fatty acids with chain lengths of 16, 18, or 20 carbon atoms. On a noninductive surface, the inhibition was only observed upon stimulation with 1,16-hexadecanediol or oleyl alcohol, but not upon stimulation with 8-(4-chlorophenylthio)-adenosine-3',5'-monophosphate. In the C18-series, fatty acids with a double bond in position 9 were the most active ones. At 1 μg/ml of oleic or elaidic acid, less than 30% of the germinated conidia formed appressoria. The mode of inhibition was competitive to the inducing agent. On an inductive surface, compared to a noninductive surface the concentrations of oleic and elaidic acid needed for inhibition of appressorium formation were one order of magnitude higher. Methyl esters of inhibitory fatty acids and acids with two double bonds were not active. Like oleyl alcohol, elaidyl alcohol and petroselinyl alcohol stimulated infection structure formation on the noninductive surface.
Waterborne Toxoplasmosis, Brazil, from Field to Gene (2006)

Water was the suspected vehicle of Toxoplasma gondii dissemination in a toxoplasmosis outbreak in Brazil. A case-control study and geographic mapping of cases were performed. T. gondii was isolated directly from the implicated water and genotyped as SAG 2 type I.
Reduction in bacterial ooze formation on immature fruitlets after preventive treatments of Fosethyl-Al against fire blight Erwinia amylovora. (2010)

Fire blight, caused by the bacterium Erwinia amylovora (Burill Winslow et al.), is a very important bacterial disease on apple and pear orchards with devastating effects in some production area and in some years. Fire blight control consists in a whole strategy of measures that should start with control measures in and around the fruit tree nurseries. Only the use of Vacciplant (Laminarin), an inducer of the self-defence mechanism, is registered in Belgium since 2009. In other European countries Fosethyl-Al has been registered for fire blight control. Recently, research trials have been done at Pcfruit research station for several years on the activity of ALiette (fosethyl-Al) against fire blight. Fosethyl-Al, also a plant defence enhancing molecule, applied preventively 3 times at a dose of 3.75 kg/ha standard orchard (3 x 3000 g a.i./ha standard orchard), showed a reduction in the host susceptibility and decreased the disease development on artificial inoculated flower clusters and shoots. Also a clear reduction in the ooze droplet formation on artificially inoculated immature fruitlets has been observed with this molecule. This reduction in the bacterial ooze formation is considered as a very important factor in the spread of the disease in the orchard.
Dabigatran Does Not Prolong the QT Interval with Supratherapeutic Exposure: a Thorough QT Study in Healthy Subjects (2013)

This thorough QT study demonstrated that therapeutic and fourfold supratherapeutic doses of dabigatran etexilate do not prolong QT intervals.
Geo-radar in tunneling - The radar tunnel (1992)

Between 75 and 100 kilometres of tunnel are excavated in Norway each year. In many of these tunnelling projects, the contractor is looking for methods to acquire geological information during the excavation process, enabling him to carry out the project safely and in a cost effective manner. Often the contractor would like to know the geological situation ahead of the tunnel front or the rock thickness and quality above the tunnel.
Das relationale Datenbanksystem MEMODAX - zum aktuellen Stand der Entwicklung (1984)

MEMODAX est un systeme de base de donnees relationnelles actuellement en developpement a l'Universite technique de Aachen. Cet article donne un apercu de la situation presente du systeme avec insistance sur ses DDL et ses DML
Conformational analysis of melittin in solution phase: Vibrational circular dichroism study (2003)

The vibrational absorption and vibrational circular dichroism (VCD) spectra of melittin in D(2)O solutions at different pH values, different salt concentrations, or different 2,2,2-trifluoroethanol (TFE) concentrations are recorded in the amide I' (1850-1600 cm(-1)) region. Two models are used to simulate this peptide in different conditions, and a coupled oscillator program is used to obtain the calculated absorption and VCD spectra. This study indicates that melittin adopts a mixed structure in D(2)O solution at low pH, low salt concentration, or low TFE concentration. With an increase in pH, salt concentration, or TFE concentration, the structure changes to alpha-helix and further increases lead to aggregation. These results demonstrate the versatility of VCD in probing the conformations of peptides under different environmental perturbations.
A tool set for the design of asynchronous circuits with bundled-data implementation (2011)

This paper proposes a tool set for the design of asynchronous circuits with bundled-data implementation. Using the proposed tool set with commercial CAD tools, asynchronous circuits with bundled-data implementation can be designed easily. Through the experiments, this paper evaluates synthesized circuits using the proposed tool set in terms of area, performance, power consumption, and energy consumption comparing with synchronous counterparts.
Improving antibiotic prescribing for adults with community acquired pneumonia: Does a computerised decision support system achieve more than academic detailing alone? – a time series analysis (2008)

The ideal method to encourage uptake of clinical guidelines in hospitals is not known. Several strategies have been suggested. This study evaluates the impact of academic detailing and a computerised decision support system (CDSS) on clinicians' prescribing behaviour for patients with community acquired pneumonia (CAP). The management of all patients presenting to the emergency department over three successive time periods was evaluated; the baseline, academic detailing and CDSS periods. The rate of empiric antibiotic prescribing that was concordant with recommendations was studied over time comparing pre and post periods and using an interrupted time series analysis. The odds ratio for concordant therapy in the academic detailing period, after adjustment for age, illness severity and suspicion of aspiration, compared with the baseline period was OR = 2.79 [1.88, 4.14], p < 0.01, and for the computerised decision support period compared to the academic detailing period was OR = 1.99 [1.07, 3.69], p = 0.02. During the first months of the computerised decision support period an improvement in the appropriateness of antibiotic prescribing was demonstrated, which was greater than that expected to have occurred with time and academic detailing alone, based on predictions from a binary logistic model. Deployment of a computerised decision support system was associated with an early improvement in antibiotic prescribing practices which was greater than the changes seen with academic detailing. The sustainability of this intervention requires further evaluation.
Ena/VASP: towards resolving a pointed controversy at the barbed end (2009)

Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance, endothelial barrier function, and cancer cell invasion and metastasis. Although considerable evidence points towards an anti-capping mechanism for Ena/VASP function, some controversy remains. Here, we evaluate the evidence for and against the anti-capping hypothesis, including results from some recent structural and biochemical studies that shed new light on this issue. In addition, we describe several alternate mechanisms that Ena/VASP proteins may utilize to regulate actin dynamics in vivo, including inhibition of branching, bundling and profilin-actin recruitment.
Dreidimensionale Darstellung in der Ultraschalldiagnostik: Erste Ergebnisse (2008)

A new method of three-dimensional (3-D) reconstruction of 2-D ultrasound images of the kidney is described. It is based on a coordinated spatial reconstruction of sequential cross-sectional images. The ultrasound head is moved longitudinally between two rails (parallel sections) and rotated. With a suitable computer program and contouring of each cross-section (so that the organ limits are defined for the computer) these cross-sectional pictures can be reconstructed into 3-D organ images. The kidney can then be presented spatially either as a binary picture or with closed surface. Ultrasound investigators are still unaccustomed to colour reproduction of 3-D reconstructed organs. It remains to be seen whether the method is valuable in routine clinical use.
Ca2+ imaging of mouse neocortical interneurone dendrites: Contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics (2003)

In this second study, we have combined two-photon calcium imaging with whole-cell recording and anatomic reconstructions to directly characterize synaptically evoked calcium signals in three types of mouse V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), calretinin-positive irregular spikers (IS), and adapting cells (AD). We observed that subthreshold synaptic activation evoked calcium signals locally restricted to individual dendritic compartments. These signals were mediated by NMDA receptors (NMDARs) in AD and IS cells, whereas in FS cells, calcium-permeable AMPA receptors (CP-AMPARs) provided an additional and kinetically distinct influx. Furthermore, even a single, subthreshold synaptic activation evoked a larger dendritic calcium influx than backpropagating action potentials. Our results demonstrate that NMDARs dominate subthreshold calcium dynamics in interneurones and reveal the functional contribution of CP-AMPARs to a specific subclass of cortical interneurone. These data highlight different strategies in dendritic signal processing by distinct classes of interneurones.
Nonparametric method for detecting the number of narrowband signals without eigendecomposition in array processing (2006)

A computational simple and efficient nonparametric method for estimating the number of signals without eigendecompo-sition (MENSE) is proposed for the narrowband signals im-pinging on a uniform linear array (ULA). When finite array data are available, a new detection criterion is formulated in terms of the row elements of the QR upper-triangular fac-tor of the auto-product of a matrix formed from the cross-correlations between some sensor data. Then the number of signals is determined as a value for which this ratio criterion is maximized, where the QR decomposition with column pivoting is also used to improve detection performance. The proposed estimator is asymptotically consistent, and it is su-perior in detecting closely-spaced signals with a small num-ber of snapshots and/or at low signal-to-noise ratio (SNR). 1.
Intraperitoneal Nebulization of Ropivacaine for Pain Control After Laparoscopic Cholecystectomy (2014)

Ingelmo, P. M.; Bucciero, M.; Somaini, M.; Sahillioğlu, E.; Garbagnati, A.; Charton, A.; Rossini, V.; Sacchi, V.; Scardelli, M.; Lometti, A.; Joshi, G. P.; Fumagalli, R.; Diemunsch, P. Author Information
Incomplete meniscal healing in early second-look arthroscopy does not indicate failure of repair: a case series (2023)

Abstract Purpose To assess if incomplete meniscal healing during second-look arthroscopy at six to eight weeks after all-inside suture hook meniscus repair results in longer-term failure of repair in patients with restored knee stability. Methods From 2008 to 2013, 41 patients with post-traumatic, longitudinal, vertical, complete meniscal tears with concomitant ACL injury were treated via a two-stage surgical procedure and prospectively evaluated. In the first stage, all-inside meniscus repair was performed using suture hook passers and non-absorbable sutures. In total, there were 26 medial and 16 lateral meniscus tears. A second-stage ACL reconstruction, performed six to eight weeks later, served as an early second-look arthroscopic evaluation of meniscal healing. Clinical follow-up was performed at a minimum of 24 months. Results Second-look arthroscopy revealed 31 cases (75.6%) of complete and ten cases (24.4%) of incomplete meniscal healing. Two patients were lost prior to follow-up, and three were excluded due to recurrent instability. Therefore, 36 patients were assessed at the final follow-up. All patients with complete meniscal healing during second-look arthroscopy achieved clinical success at follow-up. Six out of nine (66.7%) of patients with incomplete meniscal healing during second-look arthroscopy achieved clinical success at follow-up ( p = 0.012). One saphenous neuropathy occurred (2.4%). Conclusion Incomplete meniscal healing during early second-look arthroscopy after all-inside meniscal repair using suture hook passers and non-absorbable sutures did not necessarily result in longer-term failure in patients with restored knee stability. The described method of meniscal repair was associated with a low rate of symptomatic re-tears and complications.
Ultrastructural Renal Changes in Juvenile Diabetics (1967)

Electron microscopic examination of percutaneous renal biopsy specimens from 12 normotensive patients ranging in age from 13 to 23 years with diabetes of juvenile onset revealed that glomerular alteration is not an invariable manifestation of early stages of diabetes and that changes in glomerular basement membrane most likely result from rather than precede those of the mesangium. Arteriolar hyalinosis was the most frequent alteration observed in these patients, occurring in 75% (9) of the specimens. This abnormally high prevalence of arteriolar hyalinosis is in accord with the recognized tendency of vascular disease to develop in patients with diabetes. The ultrastructural appearance of the renal arteriolar hyalinosis in our patients was indistinguishable from that in patients with essential and renal hyptertension and that in some normotensive older adults. These observations provide some information unifying the triad of hypertension, aging, and diabetes mellitus.
Dynamic Sensor Scheduling for Thermal Management in Biological Wireless Sensor Networks (2013)

Biological sensors are a very promising technology that will take healthcare to the next level. However, there are obstacles that must be overcome before the full potential of this technology can be realized. One such obstacle is that the heat generated by biological sensors implanted into a human body might damage the tissues around them. Dynamic sensor scheduling is one way to manage and evenly distribute the generated heat. In this paper, the dynamic sensor scheduling problem is formulated as a Markov decision process (MDP). Unlike previous works, the temperature increase in the tissues caused by the generated heat is incorporated into the model. The solution of the model gives an optimal policy that when executed will result in the maximum possible network lifetime under a constraint on the maximum temperature level tolerable by the patient's body. In order to obtain the optimal policy in a lesser amount of time, two specific types of states are aggregated to produce a considerably smaller MDP model equivalent to the original one. Numerical and simulation results are presented to show the validity of the model and superiority of the optimal policy produced by it when compared with two policies one of which is specifically designed for biological wireless sensor networks.
Single-mode laser action in quantum cascade lasers with spiral-shaped chaotic resonators (2007)

The authors have fabricated and characterized quantum cascade lasers with spiral-shaped microresonators. The lasers operate in pulsed mode at room temperature with peak optical power greater than 20mW and in continuous wave at temperatures up to 125K. They exhibit single-mode emission in both pulsed mode and continuous wave operation, with a 30dB side-mode suppression ratio at injection currents well above threshold. Subthreshold spectral measurements indicate that the spiral cavities support whispering-gallery-like modes. Single-mode lasing occurs on one of these modes. Far-field profiles reveal enhanced directionality compared to microdisk lasers.
Preparation and enzymatic degradation of monosulfogangliotriaosylceramide. (1985)

Gangliotriaosylceramide 3'-sulfate (GgOse3Cer-II3-sulfate) contains the sugar sequence similar to that of GM2 ganglioside except that the NeuAc in GM2 is replaced by a sulfate group. Due to this structural similarity, we have studied the in vitro synthesis of GgOse3Cer-II3-sulfate using the system for GM2. Our results showed that GgOse3Cer-II3-sulfate could be synthesized from lactosylceramide 3'-sulfate and UDP-GalNAc catalyzed by N-acetylgalactosaminyltransferase prepared from rat brain (Dicesare, J. L., and Dain, J. A. (1971) Biochim. Biophys. Acta 231, 385-393). As in the case of GM2, the GgOse3Cer-II3-sulfate biosynthesized in vitro or isolated from rat kidney could also be cleaved by human beta-hexosaminidase A in the presence of GM2-activator (Li, S.-C., Hirabayashi, Y., and Li, Y.-T. (1981) J. Biol. Chem. 256, 6234-6240). The fact that the GM2-activator could stimulate beta-hexosaminidase A to hydrolyze both GM2 and Gg-Ose3Cer-II3-sulfate indicates that these two glycolipids may be catabolyzed by the same mechanism.
Exercise-induced cardio-pulmonary remodelling in endurance athletes: Not only the heart adapts (2019)

Exercise-induced remodelling involves, besides the cardiac chambers, the pulmonary circulation and is associated with an increased estimated PVR. A small subset of athletes exhibited substantial increase of estimated PVR related to pronounced pulmonary circulation remodelling and reduced right ventricular systolic function.
Analysis of transferred fragrance and its forensic implications (2016)

Perfumes are widely used by many people in developed countries, and a large number of both men and women wear perfumes on a daily basis. Analysis of perfume trace materials from clothing is not commonly employed within forensic casework, yet as a form of trace evidence it has the potential to provide valuable intelligence. In order to appreciate the value of trace evidence there is a fundamental need for an evidence base that can both offer insight into how a trace material behaves under different scenarios and activities, and from which inferences can be made. With this purpose a gas chromatography-mass spectrometry method for trace analysis of perfumes was developed. This paper presents two different series of experiments that investigate the dynamics of perfume transfer as a factor of perfume ageing time, and as a factor of perfume contact time. Empirical data showed that both perfume ageing time, and perfume contact time play a key role in the number of perfume components transferred. These studies have implication for forensic protocols, specifically for perfume trace evidence collection, analysis, interpretation, and presentation, and there is potentially great value in analysing perfumes from clothing exhibits in forensic enquiries that involve close contact between individuals, such as sexual assaults.
Calculation of Heat Transfer and Drag Coefficients for Aircraft Geometric Models (2022)

A numerical model to calculate the heat transfer and resistance coefficients near the bodies of complex geometric shapes moving at high velocity is formulated. The processes of heat and mass transfer and flow around aircraft elements are considered. An algorithm for calculating heat fluxes and the heat transfer coefficient is proposed. The developed numerical technique can give an idea of the essential features of the flow, heat transfer at the end keels of the wings, and integral layouts of high-speed aircraft. An approximate mathematical model for calculating the heat transfer processes and resistance coefficients near the bodies of complex geometric shapes moving at high speed in the Earth’s atmosphere is formulated. The calculated results for convective heat transfer and friction coefficients for the X-33 and X-43 vehicles are obtained.
Longest Common Subsequence as Private Search. (2009)

At STOC 2006 and CRYPTO 2007, Beimel et al. introduced a set of privacy requirements for algorithms that solve search problems. In this paper, we consider the longest common subsequence (LCS) problem as a private search problem, where the task is to find a string of (or embedding corresponding to) an LCS. We show that deterministic selection strategies do not meet the privacy guarantees considered for private search problems and, in fact, may “leak” an amount of information proportional to the entire input. We then put forth and investigate several privacy structures for the LCS problem and design new and efficient output sampling and equivalence protecting algorithms that provably meet the corresponding privacy notions. Along the way, we also provide output sampling and equivalence protecting algorithms for finite regular languages, which may be of independent interest.
Efficacy and Safety of Doxazosin GITS over 4 weeks for the Treatment of Non-neurogenic Voiding Dysfunction in Females: Short-term Outcomes (2008)

We administered doxazosin gastrointestinal therapeutic system (GITS) to women with non-neurogenic voiding dysfunction to evaluate its therapeutic effects.
CubeLSI: An effective and efficient method for searching resources in social tagging systems (2011)

In a social tagging system, resources (such as photos, video and web pages) are associated with tags. These tags allow the resources to be effectively searched through tag-based keyword matching using traditional IR techniques. We note that in many such systems, tags of a resource are often assigned by a diverse audience of causal users (taggers). This leads to two issues that gravely affect the effectiveness of resource retrieval: (1) Noise: tags are picked from an uncontrolled vocabulary and are assigned by untrained taggers. The tags are thus noisy features in resource retrieval. (2) A multitude of aspects: different taggers focus on different aspects of a resource. Representing a resource using a flattened bag of tags ignores this important diversity of taggers. To improve the effectiveness of resource retrieval in social tagging systems, we propose CubeLSI - a technique that extends traditional LSI to include taggers as another dimension of feature space of resources. We compare CubeLSI against a number of other tag-based retrieval models and show that CubeLSI significantly outperforms the other models in terms of retrieval accuracy. We also prove two interesting theorems that allow CubeLSI to be very efficiently computed despite the much enlarged feature space it employs.
Palladium‐Catalyzed Hydroxycarbonylation of Diisobutene: Systematic Optimization by Central Composite Design (2022)

Abstract The selection of suitable catalysts and reaction conditions are key elements for efficient process development. In this work, stability studies of homogeneous palladium catalysts used for the hydroxycarbonylation of olefins to aliphatic carboxylic acids are presented. Based on this, the hydroxycarbonylation of diisobutene, which represents an industrially relevant mixture of olefins, was investigated and optimized by means of central composite design with respect to the yield of the target product 3,5,5‐trimethylhexanoic acid. The modeling succeeds with high accuracy and allows to gain information about interactions between different factors in the reaction system. This allows a more accurate prediction of the reaction behavior and permits easier future scale‐up of such processes.