gebhart/patrepeval huggingface dataset:
A Role for Saccharomyces cerevisiae Fatty Acid Activation Protein 4 in Regulating ProteinN-Myristoylation during Entry into Stationary Phase (1998)

Saccharomyces cerevisiae contains four known acyl-CoA synthetases (fatty acid activation proteins, Faaps). Faa1p and Faa4p activate exogenously derived fatty acids. Acyl-CoA metabolism plays a critical role in regulating protein N-myristoylation by the essential enzyme, myristoyl-CoA:protein N-myristoyltransferase (Nmt1p). In this report, we have examined whether Faa1p and Faa4p have distinct roles in affecting protein N-myristoylation as cells transition from growth in rich media to a growth-arrested state during nutrient deprivation (stationary phase). The colony-forming potential of 10 isogenic strains was defined as a function of time spent in stationary phase. These strains contained either a wild type or mutant NMT1 allele, and wild type or null alleles of each FAA. Only the combination of the Nmt mutant (nmt451Dp; reduced affinity for myristoyl-CoA) and loss of Faa4p produced a dramatic loss of colony-forming units (CFU). The progressive millionfold reduction in CFU was associated with a deficiency in protein N-myristoylation that first appeared during logarithmic growth, worsened through the post-diauxic phase, and became extreme in stationary phase. Northern and Western blot analyses plus N-myristoyltransferase assays showed that Nmt is normally present only during the log and diauxic/post-diauxic periods, indicating that N-myristoylproteins present in stationary phase are "inherited" from these earlier phases. Moreover, FAA4 is the only FAA induced during the critical diauxic/early post-diauxic transition. Although substitution of nmt1-451D for NMT1 results in deficiencies in protein N-myristoylation, these deficiencies are modest and limited by compensatory responses that include augmented expression of nmt1-451D and precocious induction of FAA4 in log phase. Loss of Faa4p from nmt1-451D cells severely compromises their capacity to adequately myristoylate Nmt substrates prior to entry into stationary phase since none of the other Faaps are able to functionally compensate for its absence. To identify Nmt1p substrates that may affect maintenance of proliferative potential during stationary phase, we searched the yeast genome for known and putative N-myristoylproteins. Of the 64 genes found, 48 were successfully deleted in NMT1 cells. Removal of any one of the following nine substrates produced a loss of CFU similar to that observed in nmt1-451Dfaa4Delta cells: Arf1p, Arf2p, Sip2p, Van1p, Ptc2p, YBL049W (homology to Snf7p), YJR114W, YKR007W, and YMR077C. These proteins provide opportunities to further define the molecular mechanisms that regulate survival during stationary phase.
Discrete Shearlet Transform : New Multiscale Directional Image Representation (2009)

International audience
Supplementary Table S1 from Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer (2023)

Supplementary Table S1 from Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer
High efficiency three-phase unidirectional bucktype PFC rectifier concepts (2013)

This paper presents highly efficient three-phase unidirectional buck-type unity power factor rectifiers well-suited for various power electronic applications such as high power EV battery charging or DC distribution systems. The circuits are assembled by incorporating two auxiliary circuit branches into standard three-phase buck-type PFC topologies, each one comprising of one active switch and three diodes. This enables redundant current paths for distributing the impressed output DC currents to the AC input terminals, which can be potentially used to reduce the system's total semiconductor losses and/or increase its output power capability. The advantages of a new converter constructed with a three-phase six-switch buck-type PFC, including the principles of operation, modulation strategy and suitable control structure are described in this paper. Finally, the proposed converter is compared with the conventional six-switch buck-type converter and SWISS rectifier. According to the results, the studied AC-to-DC system is the topology of choice for a buck-type PFC.
Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes (2013)

Among patients with type 2 diabetes who had had a recent acute coronary syndrome, the rates of major adverse cardiovascular events were not increased with the DPP-4 inhibitor alogliptin as compared with placebo. (Funded by Takeda Development Center Americas; EXAMINE ClinicalTrials.gov number, NCT00968708.).
[IC‐P‐057]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY (2017)

Clinical trials of some anti-amyloid treatments have shown increased risks of cerebral microhemorrhages (MCHs) in individuals with Alzheimer disease. These are detectable with gradient-echo (GRE) MR imaging sequences and are part of the constellation of findings defined as amyloid-related imaging abnormalities (ARIA) for which the FDA has recommended monitoring during trials. The presence of 5 or more MCHs has been suggested as a criteria of exclusion from trials. Our aim was to investigate the prevalence of MCHs and their evolution with the disease process in individuals at risk for autosomal dominant Alzheimer disease (ADAD). Non-mutation carriers (NC, n=58, age=40.6±9.7years) and mutation carriers (MC, n=108, age=41.6±9.5years) underwent GRE MR sequences to detect MCH. All individuals had at least 2 imaging visits spaced by 1.9±1.1years. MCH number, siderosis, and macroscopic hemorrhages were visually quantified on each scan. Longitudinal analysis were performed to characterize the pattern of progression of MCHs with the mutation type, estimated year to symptom onset (EYO) for asymptomatic participants, and dementia using clinical dementia rating (CDR). MCH were observed in 19 participants (11%), 18 of whom were MCs (PSEN1=13, PSEN2=1 and APP=4). For all participants with MCH at baseline, the rate of increase per year was 0 for NCs and 0.88±3.66 for MCs overall, but 7.05±3.04 MCHs per year for 13 participants with 2 MCHs or more at baseline (mutation type was unassociated with rate of increase, (Figure 1z).). In MCs, the increased rate per year was higher once past the estimated symptom onset (EYO>0, p<0.0005) and when they were cognitively impaired (CDR>0, p<0.005) (Figure 2). Siderosis was detected in participants with (n=3) or without (n=2) MCH. Macrohemorrhages were present only in 2 participants with MCHs within the APP mutation type and could not be directly correlated with the presence of MCHs.
Facial Recognition From Volume-Rendered Magnetic Resonance Imaging Data (2009)

Three-dimensional (3-D) reconstructions of computed tomography (CT) and magnetic resonance (MR) brain imaging studies are a routine component of both clinical practice and clinical and translational research. A side effect of such reconstructions is the creation of a potentially recognizable face. The Health Insurance Portability and Accountability Act of 1996 (HIPAA) Privacy Rule requires that individually identifiable health information may not be used for research unless identifiers that may be associated with the health information including "Full face photographic images and other comparable images ..." are removed (de-identification). Thus, a key question is: Are reconstructed facial images comparable to full-face photographs for the purpose of identification? To address this question, MR images were selected from existing research repositories and subjects were asked to pair an MR reconstruction with one of 40 photographs. The chance probability that an observer could match a photograph with its 3-D MR image was 1 in 40 (0.025), and we considered 4 successes out of 40 (4/40, 0.1) to indicate that a subject could identify persons' faces from their 3-D MR images. Forty percent of the subjects were able to successfully match photographs with MR images with success rates higher than the null hypothesis success rate. The Blyth-Still-Casella 95% confidence interval for the 40% success rate was 29%-52%, and the 40% success rate was significantly higher ( P < 0.001) than our null hypothesis success rate of 1 in 10 (0.10).
Research on Test Paper Auto-generating Based on Improved Particle Swarm Optimization (2015)

The existing algorithm of generating test paper has the problem of low efficiency and slow convergence rate, etc. Improved particle swarm algorithm for test paper auto-generating is proposed on the basic of the particle swarm optimization algorithm and improved genetic algorithm. The algorithm uses greedy algorithm to optimize the initial population. The crossover and mutation operator of genetic algorithm are used to avoid the local convergence of population during the process of iteration. Experimental results show that the improved particle swarm optimization algorithm can applied to auto-generating test paper, which has faster speed and higher success rate.
Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) (2018)

Enzalutamide, a nonsteroidal second-generation antiandrogen, has been recently approved for the management of castration-resistant prostate cancer (CRPC). Although patients can benefit from enzalutamide at the beginning of this therapy, acquired enzalutamide resistance usually occurs within a short period. This motivated us to investigate the mechanism involved and possible approaches for overcoming enzalutamide resistance in CRPC. In the present study, we found that 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), a crucial enzyme in the mevalonate pathway for sterol biosynthesis, is elevated in enzalutamide-resistant prostate cancer cell lines. HMGCR knockdown could resensitize these cells to the drug, and HMGCR overexpression conferred resistance to it, suggesting that aberrant HMGCR expression is an important enzalutamide-resistance mechanism in prostate cancer cells. Furthermore, enzalutamide-resistant prostate cancer cells were more sensitive to statins, which are HMGCR inhibitors. Of note, a combination of simvastatin and enzalutamide significantly inhibited the growth of enzalutamide-resistant prostate cancer cells <i>in vitro</i> and tumors <i>in vivo</i> Mechanistically, simvastatin decreased protein levels of the androgen receptor (AR), which was further reduced in combination with enzalutamide. We observed that the decrease in AR may occur through simvastatin-mediated inhibition of the mTOR pathway, whose activation was associated with increased HMGCR and AR expression. These results indicate that simvastatin enhances the efficacy of enzalutamide-based therapy, highlighting the therapeutic potential of statins to overcome enzalutamide resistance in CRPC.
Real-time multi-view face detection (2003)

We present a detector-pyramid architecture for real-time multi-view face detection. Using a coarse to fine strategy, the full view is partitioned into finer and finer views. Each face detector in the pyramid detects faces of its respective view range. Its training is performed by using a new meta booting learning algorithm. This results in the first real-time multi-view face detection system which runs at 5 frames per second for 320/spl times/240 image sequence.
Selective electrostatic binding of ions by monolayers of mercaptan derivatives adsorbed to gold substrates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective electrostatic binding of ions by monolayers of mercaptan derivatives adsorbed to gold substratesLi. Sun, Bryan. Johnson, Travis. Wade, and Richard M. CrooksCite this: J. Phys. Chem. 1990, 94, 26, 8869–8871Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/j100389a005https://doi.org/10.1021/j100389a005research-articleACS PublicationsRequest reuse permissionsArticle Views357Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Asymmetric Total Synthesis of Fluvirucinine A1 (1999)

Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza-Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A(1) (1), the aglycon of fluvirucin A(1). Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.
Hemoglobin Raleigh (β1 valine →acetylalanine). Structural and functional characterization (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHemoglobin Raleigh (β1 valine →acetylalanine). Structural and functional characterizationWinston F. Moo-Penn, Katherine C. Bechtel, Robert M. Schmidt, Mary H. Johnson, Danny L. Jue, Donald E. Schmidt, William M. Dunlap, Stanley J. Opella, Joseph Bonaventura, and Celia BonaventuraCite this: Biochemistry 1977, 16, 22, 4872–4879Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://doi.org/10.1021/bi00641a019RIGHTS & PERMISSIONSArticle Views169Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Spatial light-scattering analysis as a means of characterizing and classifying non-spherical particles (1998)

Original article can be found at: http://www.iop.org/EJ/journal/0957-0233/1--Copyright Institute of Physics and IoP Publishing Ltd DOI : 10.1088/0957-0233/9/2/002
Direct Imine Acylation: Rapid Access to Diverse Heterocyclic Scaffolds (2012)

A simple and efficient procedure to prepare a range of diverse heterocycles by the direct acylation of imines using a variety of functionalized benzoic acids is described. The methodology features a novel method for N-acyliminium ion generation followed by in situ intramolecular trapping by oxygen-, nitrogen-, sulfur- and carbon-based nucleophiles. Preliminary mechanistic studies, using ReactIR, are also reported.
On the effectiveness of address-space randomization (2004)

Address-space randomization is a technique used to fortify systems against buffer overflow attacks. The idea is to introduce artificial diversity by randomizing the memory location of certain system components. This mechanism is available for both Linux (via PaX ASLR) and OpenBSD. We study the effectiveness of address-space randomization and find that its utility on 32-bit architectures is limited by the number of bits available for address randomization. In particular, we demonstrate a <i>derandomization attack</i> that will convert any standard buffer-overflow exploit into an exploit that works against systems protected by address-space randomization. The resulting exploit is as effective as the original exploit, although it takes a little longer to compromise a target machine: on average 216 seconds to compromise Apache running on a Linux PaX ASLR system. The attack does not require running code on the stack.
An array processor architecture with parallel data cache for image rendering and compositing (2002)

This paper proposes a new array architecture for MPEG-4 image compositing and 3D rendering. The emerging MPEG-4 standard for multimedia applications allows VRML-like script-based compositing of audio-visual scenes from multiple audio and visual objects. MPEG-4 supports both natural (video) and synthetic (3D) visual objects or a combination of both. Objects can be manipulated e.g. positioned, rotated, warped or duplicated by user interaction. A coprocessor architecture is presented, that works in parallel to an MPEG-4 video and audio-decoder and a floating-point geometry-processor. It performs computation and bandwidth intensive low-level tasks for image compositing and rasterization. The processor consists of a SIMD array of 16 identical DSPs to reach the required processing power for real-time image warping, alpha-blending, z-buffering and phong-shading. The processor has an object-oriented parallel cache architecture with 2D virtual address space (e.g. textures) that allows concurrent and conflict-free access to shared image data objects for all 16 DSPs.
ChemInform Abstract: PREPARATION OF AZETIDINE AND SOME N‐AROYLAZETIDINES (1974)

Abstract Aus dem N,O‐Di‐tosyl‐1‐amino‐3‐propanol (I) entsteht nach einem verbesserten Verfahren mit Alkali das N‐Tosyl‐azetidin (II), das mit Natrium/Naphthalin das freie Azetidin (III) ergibt.
Meta-Analysis Identifies Pleiotropic Loci Controlling Phenotypic Trade-offs in Sorghum (2020)

ABSTRACT Community association populations are composed of phenotypically and genetically diverse accessions. Once these populations are genotyped, the resulting marker data can be reused by different groups investigating the genetic basis of different traits. Because the same genotypes are observed and scored for a wide range of traits in different environments, these populations represent a unique resource to investigate both pleiotropy and genotype by environment interactions. Here we assembled a set of 234 separate trait datasets for the Sorghum Association Panel, a group of 406 sorghum genotypes widely employed by the sorghum genetics community. Comparison of genome wide association studies conducted with two independently generated marker sets for this population demonstrate that existing genetic marker sets do not saturate the genome and likely capture only 35-43% of potentially detectable loci controlling variation for traits scored in this population. While limited evidence for pleiotropy was apparent in cross-GWAS comparisons, a multivariate adaptive shrinkage approach recovered both known pleiotropic effects of existing loci and new pleiotropic effects, particularly significant impacts of known dwarfing genes on root architecture. In addition, we identified new loci with pleiotropic effects consistent with known trade-offs in sorghum development. These results demonstrate the potential for mining existing trait datasets from widely used community association populations to enable new discoveries from existing trait datasets as new, denser genetic marker datasets are generated for existing community association populations.
Facile Synthetic Routes to Phenylene and Triazine Core Based Dendritic Cobaltabisdicarbollides (2010)

The synthesis and thermal properties of phenylene and triazine core based symmetrical macromolecules containing three to six cobaltabis(dicarbollide) clusters are reported. The zwitterionic oxonium derivative of cobaltabis(dicarbollide), [3,3′-Co(8-C4H8O2-1,2-C2B9H10)(1′,2′-C2B9H11)], has been used for the synthetic transformations, and silicon tetrachloride and triflic acid were used as the cyclotrimerization reagents. Compounds containing multiple cobaltabis(dicarbollide) clusters are found to be extremely thermally stable, and only a 10−30% mass loss occurred up to 700 °C.
Enantioselective β‐Arylation of Ketones Enabled by Lithiation/Borylation/1,4‐Addition Sequence Under Flow Conditions (2012)

Die erste mehrstufige asymmetrische Katalyse in einem Strömungsreaktor wurde durch einer Sequenz aus Lithiierung, Borylierung und Rhodium-katalysierter 1,4-Addition realisiert. Die dreistufige Sequenz geht von einfach erhältlichen, preiswerten Arylbromiden aus und liefert β-arylierte Ketone in guten Ausbeuten und mit hohen Enantioselektivitäten. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Purification of Aqueous Plutonium Chloride Solutions Via Precipitation and Washing (2003)

Pyrochemical operations at Los Alamos Plutonium Facility (TA-55) use high temperature melt s of calcium chloride for the reduction of plutonium oxide to plutonium metal and hi gh temperature combined melts of sodium chloride and potassium chloride mixtures for the electrorefining purification of plutonium metal . The remaining plutonium and americium are recovered from thes e salts by dissolution in concentrated hydrochloric acid followed by either solvent extraction or io n exchange for isolation and ultimately converted to oxide after precipitation with oxalic acid . Figur e 1 illustrates the current aqueous chloride flow sheet used for plutonium processing at TA-55 .
Imaging for understanding speech communication: Advances and challenges (2005)

Research in speech communication has relied on a variety of instrumentation methods to illuminate details of speech production and perception. One longstanding challenge has been the ability to examine real-time changes in the shaping of the vocal tract; a goal that has been furthered by imaging techniques such as ultrasound, movement tracking, and magnetic resonance imaging. The spatial and temporal resolution afforded by these techniques, however, has limited the scope of the investigations that could be carried out. In this talk, we focus on some recent advances in magnetic resonance imaging that allow us to perform near real-time investigations on the dynamics of vocal tract shaping during speech. Examples include Demolin et al. (2000) (4–5 images/second, ultra-fast turbo spin echo) and Mady et al. (2001,2002) (8 images/second, T1 fast gradient echo). A recent study by Narayanan et al. (2004) that used a spiral readout scheme to accelerate image acquisition has allowed for image reconstruction rates of 24 images/second. While these developments offer exciting prospects, a number of challenges lie ahead, including: (1) improving image acquisition protocols, hardware for enhancing signal-to-noise ratio, and optimizing spatial sampling; (2) acquiring quality synchronized audio; and (3) analyzing and modeling image data including cross-modality registration. [Work supported by NIH and NSF.]