gebhart/patrepeval huggingface dataset:
Soft tissue‐related complications and management around dental implants (2019)

Implant installation for replacing missing teeth is a frequent treatment procedure with high long-term survival and success rates. However, the success of implant therapy may be jeopardized by several complications related to mistakes in treatment planning, surgical procedure, management of hard and soft tissues, and infections. Increasing evidence suggests that the stability of the soft tissues surrounding osseointegrated dental implants may substantially influence long-term clinical stability and esthetics. Therefore, when implant therapy is planned, the clinician must not only be able to perform the appropriate steps to maintain/create a stable soft tissue, but also needs to be aware of the potential sources for complications and possess the adequate knowledge for their appropriate management. The present paper provides an overview of the most important aspects related to the prevention and management of soft tissue-related complications in conjunction with implant therapy. The current literature indicates that the presence of an adequate width of keratinized attached mucosa around dental implants may lead to better soft and hard tissue stability, less plaque accumulation, limited soft tissue recession, and lower incidence of peri-implant mucositis. Proper implant positioning by carefully considering appropriate mesio-distal and bucco-lingual dimensions and implant angulation may prevent the loss of interdental soft tissues and development of soft tissue recessions. To optimize the width of keratinized attached mucosa, the appropriate soft tissue augmentation protocol should be selected for each particular indication. When the use of autogenous soft tissue grafts is planned, a thorough knowledge of the anatomical structures is mandatory in order to harvest soft tissue grafts of an appropriate quality and quantity and to avoid/minimize postoperative complications. Finally, the clinician needs to master the necessary steps in order to manage complications related to extensive bleeding and tissue necrosis that may occur in conjunction with soft tissue augmentation procedures.
Entwicklung einer Immuntherapie mit gegen EGFR-gerichteten chimären Antigenrezeptor (CAR) T-Zellen bei Kopf-Hals-Karzinomen (2020)

Einleitung Immuntherapie bietet effektive, innovative Optionen in der Behandlung von Patienten mit Plattenepithelkarzinomen im Kopf-Hals-Bereich (KHT). Gegen EGFR (epidermal growth factor receptor) gerichtete Antikörper sind therapeutisch bereits etabliert. Neben Checkpointinhibitoren findet die Immuntherapie mit chimären Antigenrezeptor (CAR) T-Zellen (adoptiver T-Zelltransfer) erste klinische Anwendungen. Diese Erkenntnisse wurden genutzt, um gegen EGFR-gerichtete CAR T-Zellen für die Therapie von KHT in-vitro zu etablieren.
The activation of specific gene transcription in the adipose conversion of 3T3 cells (1985)

During the adipose conversion of 3T3 cells, there occur sequential changes in cellular protein and mRNA composition. To determine if there are also changes in transcription, we have studied the transcripts of specific genes in isolated nuclei prepared before and after adipose conversion. Transcription of three genes encoding adipocyte-specific proteins was detectable only in adipocytes, whereas transcription of actin and collagen type I genes occurred in both adipocytes and preadipocytes. The activation of transcription of adipocyte-specific genes was not synchronous. Thus temporal differences in the appearance of different adipocyte mRNAs probably result from differences in the times of activation of transcription.
A compact adaptive equalizer IC for HIPERLAN system (2002)

The design of a compact high-symbol-rate adaptive equalizer IC for the receiver of a high-speed local area network that meets the ETSI HIPERLAN standard is presented in this paper. Although the HIPERLAN defines a slowly time-varying multi-path fading-channel system, the Inter-Symbol Interference (ISI) problem is still very severe since its data rate is up to 23.5 Mbps. An Adaptive Decision Feedback Equalizer (ADFE) is selected to overcome this problem, however, the FIR filters of the ADFE require high hardware cost for complex-number computation. In this work, we select the sequential architecture to reduce the hardware cost. The penalty of adopting the sequential architecture is that several internal clocks with a much higher operating frequency (235 MHz) and the corresponding high-speed components are required. In order to generate internal clocks, we embed an All Digital Phase-Locked Loop (ADPLL) in this chip. Meanwhile, the design of high speed multipliers and adders are achieved based on the combination of PTL, CPL, and CPL-TG CMOS logic circuits. Finally, our ADFE chip is designed in a 3.3 V 0.35 /spl mu/m CMOS technology with only 3/spl times/2.8-mm/sup 2/ core area and 1 W power dissipation.
Mixed Cryoglobulinemia in Chronic Hepatitis C Infection A Clinicopathologic Analysis of 10 Cases and Review of Recent Literature (1994)

We present 10 cases of mixed cryoglobulinemia in patients infected with hepatitis C, including pertinent clinical, serologic, and pathological data. The findings attributable to MC appear to be similar in patients who are HCV-infected as in those with unknown HCV status. The prevalence of MC in HCV-infected patients appears to be lower in our region (13%) than in southern Europe (50-90%) although some of this difference is due to our requirement that patients included in our study have a cryocrit of at least 5%. In our patients, cryoglobulins were shown to be deposited in skin and kidney, but not in liver. The mechanisms by which HCV and MC are related remain uncertain. Although we and others have evidence for enrichment of HCV RNA in the cryoprecipitates of some patients, this was not always the case, and it is not yet clear that this finding is of fundamental pathogenic importance. Finally, it appears that some patients with HCV and MC may have a beneficial clinical response of vasculitic symptoms to therapy with alpha-interferon, as well as to glucocorticoids or other immunosuppressants. In our group, no predictors were apparent to distinguish responders from nonresponders before treatment. Similarly, the duration of response remains to be determined.
Γ−Xelectron level crossover in ZnSe/BeTe multiple quantum wells (2003)

We report on the photoluminescence (PL) properties of thin BeTe/ZnSe/BeTe type II quantum wells (QW's), where the $\ensuremath{\Gamma}$ electron level in ZnSe is close to the resonance with the X electron level in BeTe. The $\ensuremath{\Gamma}\ensuremath{-}X$ levels crossover modifies the nature of the interband optical transitions which are indirect in real space but direct in $\mathbf{k}$ space for the thick enough QW's and direct in real space but indirect in $\mathbf{k}$ space for the QW's thinner than 2--3 monolayers. Approaching the crossover condition from the side of thicker QW's leads to a thresholdlike quenching and spectral narrowing of the PL band. The latter effect can be explained taking into account the inhomogeneous broadening of the $\ensuremath{\Gamma}$ electron level.
Development of ultrasonic tomography for residual stress mapping. Final report (1980)

The volumetric stress distribution in nuclear reactor piping and pressure vessels is becoming an increasingly important parameter in nondestructive evaluation. This report describes research and development of instrumentation leading toward a means of measuring subsurface stress distributions in metals. Based on the principles of Computerized Tomography (CT), an ultrasonic tomographic instrument system has been developed. The microprocessor-based system uses an ultrasonic linear array to acquire time-of-flight data to an accuracy of 0.5 to 1.0 ns. The data is processed using a modified ART (Algebraic Reconstruction Technique) program. A two-dimensional map of the velocity distribution is displayed on a monitor. The velocity distribution is interpreted or calibrated in terms of stress through the acousto-elastic coefficients.
Application of a new hydrogel dural sealant that reduces epidural adhesion formation: evaluation in a large animal laminectomy model (2010)

Hydrogel prevented CSF leakage and mitigated epidural scarring without affecting healing of the dura or laminectomy site. The safety profile of the hydrogel appears favorable due to its synthetic composition, polyethylene glycol chemistry, minimal local tissue response, and lack of neurological deficits. Controlled application of such hydrogel materials may reduce the incidence of postoperative leaks, prevent adhesion formation and thus improve recovery from spinal surgery, and improve identification of tissue planes for reoperations.
Buffer layers for REBCO films for use in superconducting devices (2023)

A superconducting article includes a substrate having a biaxially textured surface. A biaxially textured buffer layer, which can be a cap layer, is supported by the substrate. The buffer layer includes a double perovskite of the formula A.sub.2B'B''O.sub.6, where A is rare earth or alkaline earth metal and B' and B'' are different transition metal cations. A biaxially textured superconductor layer is deposited so as to be supported by the buffer layer. A method of making a superconducting article is also disclosed.
Deep Learning-designed Diffractive Neural Networks (2019)

We report deep learning-based design of diffractive neural networks. Following its fabrication, a diffractive neural network can all-optically perform user-defined tasks through diffraction. We demonstrate the applications of this framework for classification and imaging tasks.
Fibrinogen Bellingham: A ?-chain R275C substitution and a ?-promoter polymorphism in a thrombotic member of an asymptomatic family (2000)

Congenital dysfibrinogenemia is a rare cause of unexplained thrombosis. However, most individuals with dysfibrinogenemia are asymptomatic, suggesting that co-morbid factors contribute to thrombo-embolic events. The potential roles of additional genetic or acquired prothrombotic risk factors are poorly understood because detailed family studies are lacking. Herein, we describe a family whose propositus was a young Caucasian man with recurrent venous thrombo-emboli and dysfibrinogenemia due to heterozygosity for an Arg-->Cys substitution at residue 275 in the gamma-chain. The only additional thrombophilic abnormality found in the proband was heterozygosity for a G/A transition at position -455 in the fibrinogen beta-chain promoter; a genotype associated with high acute phase levels of fibrinogen. The proband's father, who died of a cerebral artery thrombosis, carried the gammaR275C substitution but not the beta-promoter -455 variant. Among 14 living relatives, eight were heterozygous for one or the other mutation and only one, a 21-year-old niece, was dually affected. None had suffered bleeding or thrombosis. In vitro studies of the proband's purified fibrinogen revealed markedly abnormal thrombin-catalyzed polymerization and delayed fibrin clot lysis by tPA-activated plasmin. We hypothesize that the gammaR275C substitution predisposes to thrombosis by generating clots that are relatively resistant to fibrinolysis. The clinical risk is low, however, in the absence of an additional thrombophilic mutation. The beta-promoter variant could, theoretically, contribute to this risk by augmenting expression of the dysfibrinogen under conditions of stress. Like the common hereditary thrombophilias, heterozygous familial dysfibrinogenemia induces thrombosis in the setting of multiple prothrombotic influences.
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. (1994)

To test the popular but unproven assumption that the metaphase-anaphase transition in vertebrate somatic cells is subject to a checkpoint that monitors chromosome (i.e., kinetochore) attachment to the spindle, we filmed mitosis in 126 PtK1 cells. We found that the time from nuclear envelope breakdown to anaphase onset is linearly related (r2 = 0.85) to the duration the cell has unattached kinetochores, and that even a single unattached kinetochore delays anaphase onset. We also found that anaphase is initiated at a relatively constant 23-min average interval after the last kinetochore attaches, regardless of how long the cell possessed unattached kinetochores. From these results we conclude that vertebrate somatic cells possess a metaphase-anaphase checkpoint control that monitors sister kinetochore attachment to the spindle. We also found that some cells treated with 0.3-0.75 nM Taxol, after the last kinetochore attached to the spindle, entered anaphase and completed normal poleward chromosome motion (anaphase A) up to 3 h after the treatment--well beyond the 9-48-min range exhibited by untreated cells. The fact that spindle bipolarity and the metaphase alignment of kinetochores are maintained in these cells, and that the chromosomes move poleward during anaphase, suggests that the checkpoint monitors more than just the attachment of microtubules at sister kinetochores or the metaphase alignment of chromosomes. Our data are most consistent with the hypothesis that the checkpoint monitors an increase in tension between kinetochores and their associated microtubules as biorientation occurs.
An automated SEU fault-injection method and tool for HDLbased designs (2012)

International audience
An intestinal surgery simulator: real-time collision processing and visualization (2004)

This research work is aimed toward the development of a VR-based trainer for colon cancer removal. It enables the surgeons to interactively view and manipulate the concerned virtual organs as during a real surgery. First, we present a method for animating the small intestine and the mesentery (the tissue that connects it to the main vessels) in real-time, thus enabling user interaction through virtual surgical tools during the simulation. We present a stochastic approach for fast collision detection in highly deformable, self-colliding objects. A simple and efficient response to collisions is also introduced in order to reduce the overall animation complexity. Second, we describe a new method based on generalized cylinders for fast rendering of the intestine. An efficient curvature detection method, along with an adaptive sampling algorithm, is presented. This approach, while providing improved tessellation without the classical self-intersection problem, also allows for high-performance rendering thanks to the new 3D skinning feature available in recent GPUs. The rendering algorithm is also designed to ensure a guaranteed frame rate. Finally, we present the quantitative results of the simulations and describe the qualitative feedback obtained from the surgeons.
Metal fires and their implications for advanced reactors. (2010)

This report details the primary results of the Laboratory Directed Research and Development project (LDRD 08-0857) Metal Fires and Their Implications for Advance Reactors. Advanced reactors may employ liquid metal coolants, typically sodium, because of their many desirable qualities. This project addressed some of the significant challenges associated with the use of liquid metal coolants, primary among these being the extremely rapid oxidation (combustion) that occurs at the high operating temperatures in reactors. The project has identified a number of areas for which gaps existed in knowledge pertinent to reactor safety analyses. Experimental and analysis capabilities were developed in these areas to varying degrees. In conjunction with team participation in a DOE gap analysis panel, focus was on the oxidation of spilled sodium on thermally massive surfaces. These are spills onto surfaces that substantially cool the sodium during the oxidation process, and they are relevant because standard risk mitigation procedures seek to move spill environments into this regime through rapid draining of spilled sodium. While the spilled sodium is not quenched, the burning mode is different in that there is a transition to a smoldering mode that has not been comprehensively described previously. Prior work has described spilled sodium as a pool fire, but there is a crucial, experimentally-observed transition to a smoldering mode of oxidation. A series of experimental measurements have comprehensively described the thermal evolution of this type of sodium fire for the first time. A new physics-based model has been developed that also predicts the thermal evolution of this type of sodium fire for the first time. The model introduces smoldering oxidation through porous oxide layers to go beyond traditional pool fire analyses that have been carried out previously in order to predict experimentally observed trends. Combined, these developments add significantly to the safety analysis capabilities of the advanced-reactor community for directly relevant scenarios. Beyond the focus on the thermally-interacting and smoldering sodium pool fires, experimental and analysis capabilities for sodium spray fires have also been developed in this project.
Progesterone supplementation in the late follicular phase of an in-vitro fertilization cycle: a ‘natural’ way to time oocyte recovery? (1988)

Twenty-eight patients superovulated with clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) were given a single injection of 25 mg progesterone (P group) 4 h prior to the ovulation-indudng injection of human chorionic gonadotrophin (HCG). Plasma and urinary LH levels were significantly higher (P < 0.05) in the P group immediately prior to HCG compared to controls. Plasma progesterone concentrations were also elevated (P < 0.01) in the P group from the time of injection to oocyte recovery. The number of mature oocytes recovered was also higher (P < 0.001; 59% versus 40% in controls) and the time interval between oocyte recovery and insemination was also shorter (P < 0.01) in the P group. The pregnancy rate/replacement 15 days after oocyte recovery was 39% versus 23% in the P and control groups respectively. It was concluded that as more mature oocytes were recovered in the P group, progesterone supplementation in the late follicular phase may be beneficial for patients undergoing GIFT. This was borne out when the first two GIFT patients pretreated in this way became pregnant.
Microparticle ratiometric oxygen sensors utilizing near-infrared emitting quantum dots (2010)

Luminescent sensors incorporating two luminophores, an indicator and a reference, offer many advantages over intensity measurements from sensors made with one indicator dye. Quantum dots have yet to be widely employed as insensitive reference luminophores in such systems. This work describes the use of near-infrared emitting quantum dots in conjunction with a long-lifetime platinum(II) porphyrin phosphor in a microsphere-based, ratiometric oxygen sensor. The process for self-assembly of the nanocomposite system was developed, and the response and photostability of the prototypes were investigated. Results indicate the sensors possess excellent sensitivity (K(SV) = 0.00826 µM(-1)) at oxygen concentrations below 300 µM and were resistant to photobleaching. The sensor luminophores displayed minimal spectral overlap and little interference from excitation light, preventing the need for optical filters. A reversible photoenhancement of the quantum dot signal was also observed when exposed for extended periods of time. This work demonstrates the advantages of incorporating long-wavelength quantum dots into ratiometric intensity sensing schemes and highlights some key limitations that must be considered in their use.
ChemInform Abstract: Scandium Trifluoromethanesulfonate‐Catalyzed Cleavage of Esters Bearing a Coordinative Group at a Vicinal Position. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Beating Greedy Matching in Sublinear Time (2022)

We study sublinear time algorithms for estimating the size of maximum matching in graphs. Our main result is a $(\frac{1}{2}+Ω(1))$-approximation algorithm which can be implemented in $O(n^{1+ε})$ time, where $n$ is the number of vertices and the constant $ε&gt; 0$ can be made arbitrarily small. The best known lower bound for the problem is $Ω(n)$, which holds for any constant approximation. Existing algorithms either obtain the greedy bound of $\frac{1}{2}$-approximation [Behnezhad FOCS'21], or require some assumption on the maximum degree to run in $o(n^2)$-time [Yoshida, Yamamoto, and Ito STOC'09]. We improve over these by designing a less "adaptive" augmentation algorithm for maximum matching that might be of independent interest.
Understanding Learner Strengths and Weaknesses: Assessing Performance on an Integrated Writing Task (2013)

The present study examined the factor structures across features of 446 examinees' responses to a writing task that integrates reading and listening modalities as well as reading and listening comprehension items of the TOEFL iBT® (Internet-based test). Both human and automated scores obtained for the integrated essays were utilized. Based on a series of preliminary factor analyses, a confirmatory factor analysis (CFA) identified a model that specified a higher order factor for comprehension. In the model, the Comprehension factor underlay factors representing content of the written essay as well as reading and listening comprehension. The Comprehension factor correlated with two writing factors—Productive Vocabulary and Sentence Conventions. Furthermore, follow-up CFA models with covariates (multiple indicators multiple causes models, or MIMIC models) were tested to compare performance between a group of 190 examinees scoring above a frequently used TOEFL iBT Total score requirement for international student admission and the other group of 128 examinees scoring below the requirement. The higher ability group performed significantly better than the lower ability group on all three constructs: Comprehension, Productive Vocabulary, and Sentence Conventions. The identification of the multiple distinct factors in this study may hold promise for obtaining writing profiles that inform instruction in contexts such as test preparation.
Acoustic Scene Classification Based on Additive Margin Softmax (2019)

In the acoustic scene classification task, different categories of scenes may contain the same acoustic events and the sound characteristics of the same category of scenes may also be significantly different, which results in poor classification performance. In order to solve this problem, a deep scene classification model based on convolutional neural network (CNN) is proposed with the additive margin softmax (AM-softmax) function as the measurement loss. The proposed model is able to acquire more categorical representative features of acoustic samples. The test results on the environmental sounds classification datasets ESC-10 and ESC- 50 show that the classification accuracy of the model is improved greatly compared with other methods based on deep learning, which achieve 94.75% and 80.25% respectively.