gebhart/patrepeval huggingface dataset:
Fractional Flow Reserve Computed from Noninvasive CT Angiography Data: Diagnostic Performance of an On-Site Clinician-operated Computational Fluid Dynamics Algorithm (2014)

With use of a reduced-order algorithm, computation of the FFR from coronary CT angiography data can be performed locally, at a regular workstation. The diagnostic accuracy of coronary CT angiography-derived computational FFR for the detection of functionally important coronary artery disease (CAD) was good and was incremental to that of coronary CT angiography within a population with a high prevalence of CAD.
Using drug similarities for discovery of possible adverse reactions (2017)

We propose a new computational method for discovery of possible adverse drug reactions. The method consists of two key steps. First we use openly available resources to semi-automatically compile a consolidated data set describing drugs and their features (e.g., chemical structure, related targets, indications or known adverse reaction). The data set is represented as a graph, which allows for definition of graph-based similarity metrics. The metrics can then be used for propagating known adverse reactions between similar drugs, which leads to weighted (i.e., ranked) predictions of previously unknown links between drugs and their possible side effects. We implemented the proposed method in the form of a software prototype and evaluated our approach by discarding known drug-side effect links from our data and checking whether our prototype is able to re-discover them. As this is an evaluation methodology used by several recent state of the art approaches, we could compare our results with them. Our approach scored best in all widely used metrics like precision, recall or the ratio of relevant predictions present among the top ranked results. The improvement was as much as 125.79% over the next best approach. For instance, the F1 score was 0.5606 (66.35% better than the next best method). Most importantly, in 95.32% of cases, the top five results contain at least one, but typically three correctly predicted side effect (36.05% better than the second best approach).
Liquid Mass Transfer at Very Low Reynolds Numbers in Packed Beds (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid Mass Transfer at Very Low Reynolds Numbers in Packed BedsE. J. Wilson and C. J. GeankoplisCite this: Ind. Eng. Chem. Fundamen. 1966, 5, 1, 9–14Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/i160017a002https://doi.org/10.1021/i160017a002research-articleACS PublicationsRequest reuse permissionsArticle Views2775Altmetric-Citations843LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Modeling and querying multidimensional data sources in Siebel Analytics (2005)

Large organizations have a multitude of data sources across the enterprise and want to obtain business value from all of them. While the majority of these data sources may be consolidated in an enterprise data warehouse, many business units have their own data marts where analysis is carried out against data stored in multidimensional data structures. It is often critical to pose queries which span both these sources. This is a challenge since these sources have differing models and query languages (SQL vs MDX). The Siebel Analytics Server enables this requirement to be fulfilled. In this paper, we describe how the multidimensional metadata is modeled relationally within Siebel Analytics, efficient SQL to MDX translation algorithms and the conversion protocols required to convert a multidimensional result into a relational rowset.
Inhibition of Inducible Nitric Oxide Synthase Prevents Myocardial and Systemic Vascular Barrier Dysfunction During Early Cardiac Allograft Rejection (1996)

NO is produced during cardiac allograft rejection by expression of inducible NO synthase (iNOS) in the rejecting heart. Recent evidence indicates that NO modulates vascular permeability under both physiological and pathophysiological conditions. The present study explored the effects of early acute cardiac allograft rejection, and specifically the effects of NO, on myocardial and systemic vascular barrier function using a quantitative double-tracer permeation method in a rat cardiac transplant model. Early allograft rejection increased albumin permeation twofold to fivefold in the allograft heart and systemic vasculature (brain, lung, sciatic nerve, diaphragm, retina, muscle, kidney, and uvea) compared with isografts and controls. There were no detectable differences in regional blood flow or hemodynamics, suggesting that increased albumin permeation resulted from increased vascular permeability. iNOS mRNA was expressed in the allograft heart and native lung and was associated with increased serum nitrite/nitrate levels. iNOS inhibition with aminoguanidine prevented or attenuated allograft heart and systemic vascular barrier dysfunction and reduced allograft serum nitrite/nitrate levels to isograft values. Aminoguanidine did not affect the mild histological changes of rejection present in allografts. These data demonstrate the novel observations that (1) endothelial barrier function is compromised in the systemic vasculature, particularly in the brain, remote from the site of allograft rejection; (2) allograft vascular barrier dysfunction is associated with increased NO production and iNOS mRNA expression in the affected tissues (eg, native lung and grafted heart); and (3) inhibition of NO production by iNOS prevents vascular barrier dysfunction in the allograft heart and systemic vasculature.
Atom probe characterization of an α-Fe/Nd/sub 2/Fe/sub 14/B nanocomposite magnet with a remaining amorphous phase (1999)

The microstructural features of Nd/sub 8/Fe/sub 76.5/Co/sub 8/B/sub 6/Cu/sub 0.5/Nb/sub 1/ nanocomposite magnet have been studied by a three-dimensional atom probe (3DAP) and transmission electron microscopy (TEM). The as-melt-spun microstructure is composed of /spl alpha/-Fe, Nd/sub 2/Fe/sub 14/B and a large fraction of intergranular amorphous phase. The annealed microstructure with optimum magnetic properties contains the same constituent phases as those in the as-quenched state, but the volume fraction of the Nd/sub 2/Fe/sub 14/B grains is increased by partial crystallization of the remaining amorphous phase. Nb and B are found to be enriched in the remaining amorphous phase. Unlike Fe/sub 3/B/Nd/sub 2/Fe/sub 14/B nanocomposite, Cu additions are not effective in refining the grain size in this system.
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-alpha/IFN-gamma-induced inflammatory response in keratinocytes and T cell-derived IL-17 (2018)

DZ2002, a reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor with immunosuppressive properties and potent therapeutic activity against various autoimmune diseases in mice. The present study was designed to characterize the potential therapeutic effects of DZ2002 on murine model of psoriasis and reveal the correlated mechanisms. In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. Topical administration of DZ2002 alleviated the imiquimod (IMQ)-induced psoriasis-like skin lesions and inflammation in mice, the therapeutic effect was comparable with the Calcipotriol. Moreover, the inflammatory skin disorder was restored by DZ2002 treatment characterized by reducing both of the CD3+ T cell accumulation and the psoriasis-specific cytokines expression. Further, we found that DZ2002 improved IMQ-induced splenomegaly and decreased the frequency of splenic IL-17-producing T cells. Our finding offered the convincing evidence that SAHH inhibitor DZ2002 might attenuate psoriasis by simultaneously interfering the abnormal activation and differentiation of keratinocytes and accumulation of IL-17-producing T cells in skin lesions.
Molecular basis for MSD and catalytic mechanism of the human formylglycine generating enzyme (2005)

acid residues and Fru-6P bound in the active site and in the Fru-2,6-P 2 effecttor site We have examined the consequesces on the enzyme structure and function of the two gene-duplication events that occured in the yeast gene compared to the prokatyotic gene.
A combination of infrared spectroscopy and morphological analysis allows successfully identifying rare crystals and atypical urinary stones. (2020)

Infrared spectroscopy (FT-IR), allows to identify, theoretically, any substance, including drug-containing calculi or calculi with unusual composition and identify false stones. This is mandatory to treat patients affected by urolithiasis with a personalized clinical approach.
Microbial Rhodopsins: The Last Two Decades (2021)

Microbial rhodopsins are diverse photoreceptive proteins containing a retinal chromophore and are found in all domains of cellular life and are even encoded in genomes of viruses. These rhodopsins make up two families: type 1 rhodopsins and the recently discovered heliorhodopsins. These families have seven transmembrane helices with similar structures but opposing membrane orientation. Microbial rhodopsins participate in a portfolio of light-driven energy and sensory transduction processes. In this review we present data collected over the last two decades about these rhodopsins and describe their diversity, functions, and biological and ecological roles.
Secure human action recognition by encrypted neural network inference (2022)

Advanced computer vision technology can provide near real-time home monitoring to support "aging in place" by detecting falls and symptoms related to seizures and stroke. Affordable webcams, together with cloud computing services (to run machine learning algorithms), can potentially bring significant social benefits. However, it has not been deployed in practice because of privacy concerns. In this paper, we propose a strategy that uses homomorphic encryption to resolve this dilemma, which guarantees information confidentiality while retaining action detection. Our protocol for secure inference can distinguish falls from activities of daily living with 86.21% sensitivity and 99.14% specificity, with an average inference latency of 1.2 seconds and 2.4 seconds on real-world test datasets using small and large neural nets, respectively. We show that our method enables a 613x speedup over the latency-optimized LoLa and achieves an average of 3.1x throughput increase in secure inference compared to the throughput-optimized nGraph-HE2.
Structural optimization under equivalent static loads transformed from dynamic loads based on displacement (1999)

Abstract All loads in the real world act dynamically on structures. Since dynamic loads are extremely difficult to handle in analysis and design, static loads are utilized with dynamic factors. The dynamic factors are generally determined from design codes or experience. Therefore, static loads may not give accurate solutions in analysis and design. An analytical method based on modal analysis in finite element analysis is proposed for the transformation of dynamic loads into equivalent static load sets. Equivalent static load sets are calculated to generate an identical displacement field in a structure with that from dynamic loads at a certain time. The process is derived mathematically and evaluated. The method is verified through numerical tests. Various characteristics are identified to match the dynamic and static behaviors. For example, the opposite direction of a dynamic load should be considered due to the vibrational response. A dynamic load is transformed into multiple equivalent static load sets according to the number of critical times. The places of the equivalent static loads can be different from those of the dynamic loads. An optimization method is defined to use the equivalent static loads. The developed optimization process has the same effect as dynamic optimization which uses the dynamic loads directly. Standard examples are solved and the results are discussed.
Collocation translation based on sentence alignment and parsing (2007)

Bien que de nombreux efforts aient t dploys pour extraire des collocations partir de corpus de textes, seule une minorit de travaux se proccupent aussi de rendre le rsultat de l'extraction prt tre utilis dans les applications TAL qui pourraient en bnficier, telles que la traduction automatique.Cet article dcrit une mthode prcise d'identification de la traduction des collocations dans un corpus parallle, qui prsente les avantages suivants : elle peut traiter des collocation flexibles (et pas seulement figes) ; elle a besoin de ressources limites et d'un pouvoir de calcul raisonnable (pas d'alignement complet, pas d'entranement) ; elle peut tre applique plusieurs paires des langues et fonctionne mme en l'absence de dictionnaires bilingues.La mthode est base sur l'information syntaxique provenant du parseur multilingue Fips.L'valuation effectue sur 4000 collocations de type verbe-objet correspondant plusieurs paires de langues a montr une prcision moyenne de 89.8% et une couverture satisfaisante (70.9%).Ces rsultats sont suprieurs ceux enregistrs dans l'valuation d'autres mthodes de traduction de collocations.
Electrical Model for Analyzing Chemical Kinetics, Lasing and Bio-Chemical Processes (2013)

In this paper we present the analogous electrical model for analyzing and determining the precise time dependence of concentrations in general first and zero order chemical reactions. In addition, the applicability of this analogous electrical model for investigating the optical and bio chemical processes is also presented. By constructing the proper analogous electrical circuit experimentally or with the help of special electrical software, the time behavior of the analyzed parameter even for extremely complicated processes can be obtained.
Multi-scale strategy and data surrogating test: two elements for the detection of time irreversibility in heart rate variability (2012)

Based on the method of multi-scale space (Pm, Gm) and data surrogating test, time-irreversibility analysis is applied to the heart rate variabilities (HRVs) from different crowds and different states, awake and asleep respectively, of healthy youths. The results show that i) the HRVs of healthy crowed have irreversible dynamics prevailingly, while the irreversibility decreases but does not disappear with aging or heart disease appearing. For example, most (more than 75%) of the congestive heart failure (CHF) patients still have irreversible dynamics; ii) for HRVs of healthy crowd, irreversible dynamics presents the daytime/nighttime rhythms and their significant difference between in daytime and in nighttime. And a stronger irreversibility is detected in nighttime. HRV is generated by the cardiac dynamic system, in which regulations usually perform via multiple feedback loops with different delays. Therefore, in order to arrive at a reliable conclusion, multi-scale strategy and data surrogating test are suggested to serve as the two elements for the detection of time irreversibility in HRV. The proposed method combines these two elements and reaches a conclusion consistent with the conclusions in previous reports.
Androgen Receptor Cross-talk with Cell Signalling Pathways (2004)

The androgen receptor (AR) is implicated in regulation of cellular events in advanced prostate cancer. It is expressed in primary tumours as well as in metastases from patients who failed endocrine therapy. Activation of the AR in metastatic tumours occurs as a result of increased sensitivity of the receptor, point mutations that alter activation spectrum and in response to various nonsteroidal compounds. Peptide growth factors that activate the signalling pathway of mitogen-activated protein kinases (MAPK) stimulate AR activity in ligand-independent or synergistic manner. Outcome of nonsteroidal activation depends on cellular and promoter context. AR activation by Her-2/neu is associated with enhanced tumour growth of the LAPC-4 xenograft. The issue whether MAPK or protein kinase Akt involved in growth factor signalling directly phosphorylate the AR is a matter of debate. AR ligand-independent activation by protein kinase A activators was also demonstrated. Under physiological conditions, potentiation of AR activity by low doses of androgen might be of importance in prostate cancer patients who receive endocrine therapy. Interleukin-6 (IL-6) and related cytokines also activate AR in a ligand-independent and synergistic manner. IL-6 is a pleiotropic regulator of tumour growth, which in some prostate cancers acts as a paracrine growth inhibitor and in other cases as an autocrine growth stimulator. Activation of the AR by IL-6 requires functional pathways of Janus kinases/signal transducers and activators of transcription factors and MAPK. Studies on AR co-activators implicated in ligand-independent activation may further improve understanding of cross-talk between signalling pathways.
All the self-testings of the singlet for two binary measurements (2016)

10.1088/1367-2630/18/2/025021
Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera (2008)

Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal activity. We investigated the species specificity of fH binding and the effect of human fH on downregulating rat (relevant for animal models) and rabbit (relevant for vaccine evaluation) complement activation. Binding to N. meningitidis was specific for human fH (low for chimpanzee fH and not detected with fH from lower primates). The addition of human fH decreased rat and rabbit C3 deposition on the bacterial surface and decreased group C bactericidal titers measured with rabbit complement 10- to 60-fold in heat-inactivated sera from human vaccinees. Administration of human fH to infant rats challenged with group B strain H44/76 resulted in an fH dose-dependent increase in CFU/ml of bacteria in blood 8 h later (P < 0.02). At the highest fH dose, 50 microg/rat, the geometric mean number of CFU per ml was higher than that in control animals (1,050 versus 43 [P < 0.005]). The data underscore the importance of binding of human fH for survival of N. meningitidis in vitro and in vivo. The species specificity of binding of human fH adds another mechanism toward our understanding of why N. meningitidis is strictly a human pathogen.
Receptor-Binding Sites on C3 and C3b (1977)

Human erythrocytes carry C3b receptors: Daudi lymphoid cells carry exclusively C3d receptors. With these two types of cells, it could be shown that isolated, uncleaved human C3 and soluble C3b possess two stable binding sites: SBS1-specific C3b receptors, and SBS2-specific for C3d receptors. Upon binding of freshly cleaved C3b (nascent C3b) via its labile binding site (generated on C3b through cleavage of C3) to the C3 acceptors on cell surfaces, the SBS2 becomes concealed. Kinetic experiments show that immediately after the action of fetal calf serum or partially purified C3b-inactivator on EAC1423b the SBS2 is accessible again. The reappearance of SBS2 does coincide with cleavage of surface-bound C3b into C3c and C3d but not with the release of C3c from the cell; C3c remains attached and is released only with delay. Concomitant with the cleavage event the number of SBS1 is reduced, stressing the importance of an unaltered steric configuration of the C3b structure for the expression of SBS1. An alternative explanation might be that the SBS1 is located at the site connecting C3c and C3d, so that it becomes altered upon dissection of the two fragments.
Security Threats and Requirements for Emergency Call Marking and Mapping (2008)

This document reviews the security threats associated with the marking
of signalling messages to indicate that they are related to an
emergency, and with the process of mapping locations to Universal
Resource Identifiers (URIs) that point to Public Safety Answering
Points (PSAPs). This mapping occurs as part of the process of routing
emergency calls through the IP network. Based on the identified
threats, this document establishes a set of security requirements for
the mapping protocol and for the handling of emergency-marked calls.
This memo provides information for the Internet community.
Development of series elastic actuator based myoelectric knee exoskeleton for trajectory generation and load augmentation (2015)

This paper describes the development and control of a series elastic actuator based myoelectric knee exoskeleton which can be used for gait rehabilitation and load augmentation purposes. The device consists of a motorized ball screw mechanism along with a spring placed between the motor and load. In load augmentation mode, the spring strain is measured to get accurate estimate of force which can be controlled in force feedback mode for amplifying force according to user's intention. User's intention is reflected in myoelectric signal. For gait rehabilitation purpose, this device has been developed to function as a normal knee joint during walking by acquiring myoelectric signals from muscles around knee and joint trajectory information. Joint angle obtained from position sensor is combined with the gait parameters acquired from EMG and they are fed to a PID servo which has been developed to control knee angle trajectory of the exoskeleton. Functioning, control and acceptability of the exoskeleton device increases to a user as the system is run and controlled by user's own intention.