gebhart/patrepeval huggingface dataset:
Highly Transparent AlON Pressurelessly Sintered from Powder Synthesized by a Novel Carbothermal Nitridation Method (2012)

Transparent AlON was pressurelessly sintered from powders synthesized by a two‐step carbothermal nitridation method, using core‐shell structured Al 2 O 3 / C mixture derived from the pyrolysis of an Al 2 O 3 /ureaformaldehyde‐resin nanocomposite precursor as the starting material. It was found that the amorphous carbon layer on the Al 2 O 3 particle surface could strongly retard the coalescence and growth of Al 2 O 3 particles during the carbothermal nitridation process. As a result, the formation temperature and particle size of the AlON powder were significantly reduced. The AlON powder synthesized showed a bimodal particle size distribution at 0.2 and 0.7 μm and was well dispersed; its maximum particle size was below 0.9 μm. Under the aid of proper sintering additive, transparent AlON ceramics with an average in‐line transmittance above 80% at visible to infrared range were obtained through pressureless sintering.
An Efficient Switching Frequency Limitation Process Applied to a High Dynamic Voltage Supply (2008)

This paper presents the analysis and design of a simple and effective switching frequency limitation process with sliding mode synthesis. The control scheme is based on self-oscillating phenomenon which naturally appears in relay feedback systems. Thanks to an analytical study, it shows that the maximum switching frequency of a sliding mode structure can always be limited by adding a simple second order filter in the feedback loop. To illustrate the implementation and the validity of this process, it is applied to a high dynamic voltage supply with a bandwidth of 2000 Hz and with a maximum switching frequency of 15 kHz. According to the experimental results, the switching frequency limitation process shows similar robustness properties to those of sliding mode control when the load and voltage supply change.
Multiple-input multiple-output Rayleigh flat fading outage capacity using channel estimation (2008)

Upper and lower bounds on the outage capacity for a multiple-input multiple-output (MIMO) Rayleigh flat fading wireless baseband communication environment are derived for the case when the channel is completely unknown at the transmitter and the receiver has access to channel state information (CSI) via pilot estimation. The bounds show that the channel estimation error significantly impacts the outage capacity. A change in the outage probability is also shown to have a larger impact on the outage capacity when the channel estimation error is small. To get an idea of how these bounds are affected by a temporally correlated channel, they are calculated when pilot symbol assisted modulation (PSAM) is employed. When the doppler frequency of the channel is increased, the outage capacity deteriorates quicker.
Optimization techniques for effective energy conservation in a three floored building (2016)

Most of the energy consumed in schools, colleges & offices is the electricity supply for lighting, cooling and other HVAC equipments. Hence, it is necessary to provide thermal insulation so that heat from outside may not enter into the building. During summer, the electricity consumption increases due to air-conditioning in these rooms to compensate for the higher ambient temperature. The present work includes design of green building for meeting civil construction requirements of gyan ganga college of technology (GGCT) which is an educational institute The energy saving expected from the proposed energy conservation measures has been calculated. This has been calculated by using application software “DESIGN BUILDER V3.2”.
Wavefront coding extends the depth of field in high numerical aperture brightfield, phase and interference contrast microscopy (2001)

Microscope modes that traditionally modify the back aperture of the imaging objective (such as phase contrast) can now be modified with a custom wavefront coding element to increase the depth of field of the system.
Feasibility of Acid–Salt Processing of Alumina-Containing Raw Materials in a Closed-Loop Process (2020)

Acid methods for processing of bauxites and aluminosilicates with high silicon content become attractive in connection with the exhaustion of natural alumina-containing resources suitable for processing by standard procedures based on using alkalis. The main problems in using acid procedures are associated with organization of closed-loop processes with low consumption of chemicals and power. The acid–salt technologies suggested by now are based on using ammonium hydrosulfate in the whole cycle and are economically inferior to the classical Bayer alkaline procedure. This study demonstrates on the laboratory level good prospects for developing a new efficient technology for alumina production from low-grade raw materials in a closed-loop process with recuperation of the consumed salt reagent in each cycle. The process takes advantage of the relationships of the aluminum and iron distribution in the solid phases and equilibrium solutions, revealed by the authors. Another feature is the use of a special method of acid retardation in nanoporous media for separating the residual amounts of the acid and salt, which are returned to the head of the process, with substantial saving of the power and chemicals.
Supplementary Figure S4 from The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer (2023)

&lt;p&gt;Figure S4. Faster clearance of AMG 160 in the NSG B2M mouse strain.&lt;/p&gt;
Associations of COVID-19 Hospitalizations, ICU Admissions, and Mortality with Black and White Race and Their Mediation by Air Pollution and Other Risk Factors in the Louisiana Industrial Corridor, March 2020–August 2021 (2023)

Louisiana ranks among the bottom five states for air pollution and mortality. Our objective was to investigate associations between race and Coronavirus Disease 2019 (COVID-19) hospitalizations, intensive care unit (ICU) admissions, and mortality over time and determine which air pollutants and other characteristics may mediate COVID-19-associated outcomes. In our cross-sectional study, we analyzed hospitalizations, ICU admissions, and mortality among positive SARS-CoV-2 cases within a healthcare system around the Louisiana Industrial Corridor over four waves of the pandemic from 1 March 2020 to 31 August 2021. Associations between race and each outcome were tested, and multiple mediation analysis was performed to test if other demographic, socioeconomic, or air pollution variables mediate the race-outcome relationships after adjusting for all available confounders. Race was associated with each outcome over the study duration and during most waves. Early in the pandemic, hospitalization, ICU admission, and mortality rates were greater among Black patients, but as the pandemic progressed, these rates became greater in White patients. However, Black patients were disproportionately represented in these measures. Our findings imply that air pollution might contribute to the disproportionate share of COVID-19 hospitalizations and mortality among Black residents in Louisiana.
Effect of Long- Term Corn Residue Grazing on Soil Properties (2017)

An experiment was conducted to evaluate the effect of long- term (16 years) corn residue grazing with cattle on soil compaction, soil structure, soil organic matter, and nutrients. Three treatments: 1) fall grazing (November through January; 1.8 to 2.5 AUM/ac), 2) spring grazing (February to middle April; 2.3 to 3.1 AUM/ac), and 3) control (no grazing) under a no- till irrigated corn- soybean system in eastern Nebraska were studied. Crop yields were increased and soil bulk density and cone index (parameters of soil compaction), wet soil aggregate stability (parameter of soil structural quality), and organic matter content were not affected by grazing during the fall. Spring grazing slightly increased crop yields while wet soil aggregate stability, bulk density, and organic matter content were unaffected. During spring grazing, only cone index was increased, but not above threshold levels. Crop residue grazing in the fall has no effect on soil and any effect from spring grazing is biologically unimportant.
BDNF gene variants and brain morphology in schizophrenia (2006)

The objective was to investigate putative associations between brain-derived neurotrophic factor gene (BDNF) polymorphisms and brain morphology in patients with schizophrenia and healthy control subjects. Four BDNF polymorphisms were genotyped and analyzed versus 39 brain volume measures in 96 patients with schizophrenia or schizoaffective disorder and 104 healthy subjects. In all subjects, quantitative data on segmented gray, white, and cerebrospinal fluid (CSF) tissue class volumes of total brain and major cerebral lobes including ventricular CSF were obtained using magnetic resonance imaging (MRI). In a randomly selected subset of this population (n = 101-122), MR volumes from cerebellar tonsil, hemispheres, and vermis subregions, striatal structures, hippocampus, and corpus callosum were also measured. The BDNF 11757 G/C polymorphism was highly significantly associated with frontal gray matter volume variation in patients alone and in patients and control subjects combined. In patients only, the 270 C/T polymorphism was associated with total caudate volume. Significant associations were demonstrated between the BDNF 11757 G/C and Val66Met polymorphisms and a global haplotype estimate of four BDNF polymorphisms and the posterior superior cerebellar vermis volume in the controls as well as in the combined group, but not in the patients. The 11757 G/C polymorphism was associated with cerebellar hemisphere white and gray matter volumes in the combined group. The BDNF -633 T/A polymorphism was associated with gray matter of the putamen in the controls. Trends for associations between several polymorphisms/haplotype estimates and MRI volumes were found. BDNF gene variation may influence brain morphology. The effects may be different in patients with schizophrenia and healthy subjects.
Nucleic Acid Drugs (2003)

Introduction Chemical Synthesis of Oligonucleotides Chemical Modifications of Oligonucleotides 2′-Modifications Alkyl- and Arylphosphonates Phosphorothioates N3′-P5′-phosphoramidates Morpholino Oligonucleotides PNAs Sterically LNAs Oligonucleotide Conjugates 5′-End Conjugates 3′-End Conjugates Mechanism of Action The Antisense Concept Steric Blocking RNase H Activation The Triplex Concept Ribozymes Structure and Reaction Mechanism Triplet Specificity Stabilization of Ribozymes Inhibition of Gene Expression Colocalization RNAi Positioning Identification of Ribozyme Accessible Sites on Target RNA Delivery Application Conclusion Acknowledgements References
873. Development of High Throughput Functional Screening of Cardiovascular Therapeutic Genes Using the HVJ-E Vector (2006)

Isolation of effective therapeutic genes to control angiogenesis is critical for the advancement of gene therapy for various diseases, including cardiovascular diseases and cancer. The goal of the present study is to screen a human cDNA library using Hemagglutinating Virus of Japan envelope (HVJ-E) vector to isolate candidate genes to regulate endothelial cell growth with potent therapeutic potential. cDNA library were randomly infused into HVJ-E vector, which were then transferred to Human Aortic Endothelial Cells (HAEC) that were seeded in 96-well plates. Then, the MTS assay revealed variable HAEC proliferation among individual wells. To characterize the candidate genes responsible for inducing or reducing endothelial cell proliferation, DNA was extracted from the cell population showing the highest or lowest degree of proliferation and was then transformed directly into E. coli. Use of this system allowed isolation of candidate genes rapidly, because HVJ-E vector does not require preparation of a viral library or packaging cell constructions. In addition, use of this vector allows easy cloning of candidate genes by transformation of E. Coli (12–16 hours). These advantages resulted in a lower probability of damage to isolated clones and in minimization of the time needed to screen for candidate genes. We further evaluated the candidate genes by c-fos promoter assay, and finally got three pro-angiogenic and two anti-angiogenic candidate genes. Interestingly, one of the identified growth suppressive gene is also known as CHMP1B or CHMP1.5, a human homologue of yeast SNF7p (sucrose non-fermenting). The CHMP family of proteins participates in intracellular membrane traffic event, of which the endocytic pathway is an important component. Further, a recent study reported that CHMP 1B binds to spastin, a protein that is abnormal in the most common form of pure hereditary spastic paraplegia. Overall, this novel system will help advance our understanding of cell biology and promote the utility of human gene therapy.
Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model (2022)

Modulation of drug transporter activity at mucosal sites of HIV-1 transmission may be exploited to optimize retention of therapeutic antiretroviral drug concentrations at target submucosal CD4+ T cells. Previously, we showed that darunavir was a substrate for the P-glycoprotein efflux drug transporter in colorectal mucosa. Equivalent studies in the cervicovaginal epithelium have not been reported. Here, we describe the development of a physiologically relevant model to investigate the permeability of antiretroviral drugs across the vaginal epithelium. Barrier properties of the HEC-1A human endometrial epithelial cell line were determined, in a dual chamber model, by measurement of transepithelial electrical resistance, immunofluorescent staining of tight junctions and bi-directional paracellular permeability of mannitol. We then applied this model to investigate the permeability of tenofovir, darunavir and dapivirine. Efflux ratios indicated that the permeability of each drug was transporter-independent in this model. Reduction of pH to physiological levels in the apical compartment increased absorptive transfer of darunavir, an effect that was reversed by inhibition of MRP efflux transport <i>via</i> MK571. Thus, low pH may increase the transfer of darunavir across the epithelial barrier <i>via</i> increased MRP transporter activity. In a previous in vivo study in the macaque model, we demonstrated increased MRP2 expression following intravaginal stimulation with darunavir which may further increase drug uptake. Stimulation with inflammatory modulators had no effect on drug permeability across HEC-1A barrier epithelium but, in the VK2/E6E7 vaginal cell line, increased expression of both efflux and uptake drug transporters which may influence darunavir disposition.
Simulation of SET Operation in Phase-Change Random Access Memories with Heater Addition and Ring-Type Contactor for Low-Power Consumption by Finite Element Modeling (2009)

A three-dimensional finite element model for phase change random access memory (PCRAM) is established for comprehensive electrical and thermal analysis during SET operation. The SET behaviours of the heater addition structure (HS) and the ring-type contact in bottom electrode (RIB) structure are compared with each other. There are two ways to reduce the RESET current, applying a high resistivity interfacial layer and building a new device structure. The simulation results indicate that the variation of SET current with different power reduction ways is little. This study takes the RESET and SET operation current into consideration, showing that the RIB structure PCRAM cell is suitable for future devices with high heat efficiency and high-density, due to its high heat efficiency in RESET operation.
Experimental evidence for super-resolution in the spherical geodesic waveguide (2013)

The previous publications (Miñano et al, 2011 and Gonzalez et al, 2012) have shown that using a Spherical Geodesic Waveguide (SGW) it can be achieved the super-resolution up to λ/3000, which is far below the classic Abbe diffraction limit, close to a set of discrete microwave frequencies. The SGW was designed and simulated in COMSOL as a thin geodesic waveguide bounded by an ideal and lossless metal. Herein we present the experimental results for a manufactured SGW, slightly modified due to fabrication requirements, showing the super-resolution up to λ/105.
Microbial reduction of Fe(III) in the Fithian and Muloorina illites: Contrasting extents and rates of bioreduction (2006)

Abstract Shewanella putrefaciens CN32 reduces Fe(III) within two illites which have different properties: the Fithian bulk fraction and the &lt;0.2 µm fraction of Muloorina. The Fithian illite contained 4.6% (w/w) total Fe, 81% of which was Fe(III). It was dominated by illite with some jarosite (∼32% of the total Fe(III)) and goethite (11% of the total Fe(III)). The Muloorina illite was pure and contained 9.2% Fe, 93% of which was Fe(III). Illite suspensions were buffered at pH 7 and were inoculated with CN32 cells with lactate as the electron donor. Select treatments included anthraquinone-2,6-disulfonate (AQDS) as an electron shuttle. Bioproduction of Fe(II) was determined by ferrozine analysis. The unreduced and bioreduced solids were characterized by Mössbauer spectroscopy, X-ray diffraction and transmission electron microscopy. The extent of Fe(III) reduction in the bulk Fithian illite was enhanced by the presence of AQDS (73%) with complete reduction of jarosite and goethite and partial reduction of illite. Mössbauer spectroscopy and chemical extraction determined that 21–25% of illite-associated Fe(III) was bioreduced. The extent of bioreduction was less in the absence of AQDS (63%) and only jarosite was completely reduced with partial reduction of goethite and illite. The XRD and TEM data revealed no significant illite dissolution or biogenic minerals, suggesting that illite was reduced in the solid state and biogenic Fe(II) from jarosite and goethite was either released to aqueous solution or adsorbed onto residual solid surfaces. In contrast, only 1% of the structural Fe(III) in Muloorina illite was bioreduced. The difference in the extent and rate of bioreduction between the two illites was probably due to the difference in layer charge and the total structural Fe content between the Fithian illite (0.56 per formula) and Muloorina illite (0.87). There may be other factors contributing to the observed differences, such as expandability, surface area and the arrangements of Fe in the octahedral sheets. The results of this study have important implications for predicting microbe-induced physical and chemical changes of clay minerals in soils and sediments.
RST-invariant digital image watermarking based on log-polar mapping and phase correlation (2003)

Based on log-polar mapping (LPM) and phase correlation, the paper presents a novel digital image watermarking scheme that is invariant to rotation, scaling, and translation (RST). We embed a watermark in the LPMs of the Fourier magnitude spectrum of an original image, and use the phase correlation between the LPM of the original image and the LPM of the watermarked image to calculate the displacement of watermark positions in the LPM domain. The scheme preserves the image quality by avoiding computing the inverse log-polar mapping (ILPM), and produces smaller correlation coefficients for unwatermarked images by using phase correlation to avoid exhaustive search. The evaluations demonstrate that the scheme is invariant to rotation and translation, invariant to scaling when the scale is in a reasonable range, and very robust to JPEG compression.
Overview of the global distribution and control of the Formosan subterranean termite. (2003)

In the United States, the number of areas infested with the Formosan subterranean termite has increased in recent years, but its worldwide distribution remains primarily in areas between ca. 35° north and south of the equator. Soil termiticide applications that have been in widespread use by the pest control industry for the half-century are intended for exclusion of soilborne termites from the structures, but their inability to kill vast colonies in soil may have allowed the establishment and increase of Coptotermesformosanus populations in many introduced areas. With the development of baits that can be used to eliminate termite colonies, there is hope that C. formosanus populations may be substantially reduced if area-wide programs are implemented.
Eccles (1885)

Journal Article Eccles Get access E. T. A. E. T. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s6-XII, Issue 288, 4 July 1885, Page 8, https://doi.org/10.1093/nq/s6-XII.288.8c Published: 04 July 1885
Retracted: RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1 (2018)

Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions and mechanisms remain to be determined. By performing bioinformatics analysis using well-established hepatocellular carcinoma (HCC) datasets, we identified a set of HCC progression-associated RBPs (HPARBPs) and found that the global expression of HPARBPs was significantly correlated with patient prognosis. Among the 42 HPARBPs, human ribosomal protein S3 (RPS3) was one of the most abundant genes whose role remains uncharacterized in HCC. Gain- and loss-of-function analyses demonstrated that RPS3 promoted HCC tumorigenesis both in vitro and in vivo. Mechanistically, we revealed that silent information regulator 1 (SIRT1) was a critical target of RPS3 and was essential for sustaining the RPS3-induced malignant phenotypes of HCC cells. RPS3 stabilized SIRT1 mRNA by binding to AUUUA motifs in the 3448-3530 region of the 3' untranslated region (UTR) of SIRT1 mRNA. In addition, we found that (5-formylfuran-2-yl) methyl 4-hydroxy-2-methylenebutanoate (FMHM) inhibited HCC progression by repressing the RPS3/SIRT1 pathway. Our study unveils a novel extra-ribosomal role of RPS3 in facilitating hepatocarcinogenesis via the post-transcriptional regulation of SIRT1 expression and proposes that the RPS3/SIRT1 pathway serves as a potential therapeutic target in HCC.
MicroRNAs in Normal and Malignant Lymphocytes (2012)

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Optical Simulation and Fabrication of Nitride-Based LEDs With the Inverted Pyramid Sidewalls (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this study, the numerical and experimental demonstrations for the enhancement of light-extraction efficiency in nitride-based LEDs with randomly inverted pyramid sidewalls (IPSs) by chemical etching of the chip edge are presented. With 20 mA injection current, it was found that forward voltages were 3.69 and 3.75 V while output powers were 7.07 and 8.95 mW for the conventional LED and inverted pyramid sidewall LED, respectively. The larger LED output power is attributed to the increased light-extraction efficiency by IPSs. </para>