gebhart/patrepeval huggingface dataset:
Parametric images of blood flow in oncology PET studies using [15O]water. (2000)

Parametric imaging provides a convenient way of visualizing regional changes in blood flow, which may be valuable in studies of tumor blood flow.
A Review of Fixed-Complexity Vector Perturbation for MU-MIMO (2015)

Recently, there has been an increasing demand of high data rates services, where several multiuser multipleinput multiple-output (MU-MIMO) techniques were introduced to meet these demands. Among these techniques, vector perturbation combined with linear precoding techniques, such as zero-forcing and minimum mean-square error, have been proven to be efficient in reducing the transmit power and hence, perform close to the optimum algorithm. In this paper, we review several fixed-complexity vector perturbation techniques and investigate their performance under both perfect and imperfect channel knowledge at the transmitter. Also, we investigate the combination of block diagonalization with vector perturbation outline its merits.
Floating effective back-gate effect on the small-signal output conductance of SOI MOSFETs (2003)

This paper investigates the influence of the silicon substrate on the ac characteristics of silicon-on-insulator (SOI) MOSFETs. It is shown for the first time that the presence of the substrate underneath the buried oxide results in two transitions (i.e., zero-pole doublets) in the frequency response of the output conductance. It is demonstrated that the appearance of these transitions, the position and amplitude of which strongly depend on the substrate doping, is caused by the variation of the potential at substrate-buried oxide interface, which we call the Floating Effective Back-Gate (FEBG) effect. A first-order small-signal equivalent circuit is proposed to support our observations.
Redefining the H-NS protein family: a diversity of specialized core and accessory forms exhibit hierarchical transcriptional network integration (2020)

H-NS is a nucleoid structuring protein and global repressor of virulence and horizontally-acquired genes in bacteria. H-NS can interact with itself or with homologous proteins, but protein family diversity and regulatory network overlap remain poorly defined. Here, we present a comprehensive phylogenetic analysis that revealed deep-branching clades, dispelling the presumption that H-NS is the progenitor of varied molecular backups. Each clade is composed exclusively of either chromosome-encoded or plasmid-encoded proteins. On chromosomes, stpA and newly discovered hlpP are core genes in specific genera, whereas hfp and newly discovered hlpC are sporadically distributed. Six clades of H-NS plasmid proteins (Hpp) exhibit ancient and dedicated associations with plasmids, including three clades with fidelity for plasmid incompatibility groups H, F or X. A proliferation of H-NS homologs in Erwiniaceae includes the first observation of potentially co-dependent H-NS forms. Conversely, the observed diversification of oligomerization domains may facilitate stable co-existence of divergent homologs in a genome. Transcriptomic and proteomic analysis in Salmonella revealed regulatory crosstalk and hierarchical control of H-NS homologs. We also discovered that H-NS is both a repressor and activator of Salmonella Pathogenicity Island 1 gene expression, and both regulatory modes are restored by Sfh (HppH) in the absence of H-NS.
SegMo: Volumetric Image Segmentation System for X-rays CT Scanning of Mechanical Assemblies (2017)

Industrial X-ray CT scanning systems (XCT) have been used for obtaining 3D shapes of mechanical parts. In this study we are interested in scanning a whole assembly made of several parts made of different materials. It has several advantages such as reducing scanning labor compared to that needed for scanning each of the parts by skipping disassembly process and also by reducing scanning operations. However, such whole assembly scanning is not a common practice as it is difficult to extract the parts from the volumetric image of the whole assembly. This process is generally called segmentation. Currently, an operator needs to spend long time on manually segmenting the volumetric image. This paper proposes a new segmentation program SegMo. It is based on a cell decomposition of the volumetric image with Morse complex defined with a function of the norm of gradient of the CT values of the image. The Morse complex has cell boundaries including parts’ boundaries. By constructing LOD (level of details) hierarchy of the Morse complex, a user can select an appropriate level of the hierarchy where the boundary of the target part is well reproduced and thus can form a region of a part. A system based on the SegMo with GUI (graphical user interface) is developed on ZVoxer system of Zodiac corporation. It has been applied to various examples to show that the SegMo system can perform segmentation more quickly and with less effort than conventional methods. In this paper, we describe the algorithm of the SegMo and its experimental results.
Movement and health beyond care, MoviS: study protocol for a randomized clinical trial on nutrition and exercise educational programs for breast cancer survivors (2023)

ClinicalTrials.gov NCT04818359 . Retrospectively registered on March 26, 2021.
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 (2023)

&lt;p&gt;Supplementary Figure Legends and Methods&lt;/p&gt;
Gene Expression–Based Model Using Formalin-Fixed Paraffin-Embedded Biopsies Predicts Overall Survival in Advanced-Stage Classical Hodgkin Lymphoma (2012)

Purpose Our aim was to reliably identify patients with advanced-stage classical Hodgkin lymphoma (cHL) at increased risk of death by developing a robust predictor of overall survival (OS) using gene expression measured in routinely available formalin-fixed paraffin-embedded tissue (FFPET). Methods Expression levels of 259 genes, including those previously reported to be associated with outcome in cHL, were determined by digital expression profiling of pretreatment FFPET biopsies from 290 patients enrolled onto the E2496 Intergroup trial comparing doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and Stanford V regimens in locally extensive and advanced-stage cHL. A model for OS separating patients into low- and high-risk groups was produced using penalized Cox regression. The model was tested in an independent cohort of 78 patients enriched for treatment failure but otherwise similar to patients in a population-based registry of patients treated with ABVD. Weighted analysis methods generated unbiased estimates of predictor performance in the population-based registry. Results A 23-gene outcome predictor was generated. The model identified a population at increased risk of death in the validation cohort. There was a 29% absolute difference in 5-year OS between the high- and low-risk groups (63% v 92%, respectively; log-rank P &lt; .001; hazard ratio, 6.7; 95% CI, 2.6 to 17.4). The predictor was superior to the International Prognostic Score and CD68 immunohistochemistry in multivariate analyses. Conclusion A gene expression–based predictor, developed in and applicable to routinely available FFPET biopsies, identifies patients with advanced-stage cHL at increased risk of death when treated with standard-intensity up-front regimens.
Chronic lung allograft rejection and airway microvasculature: Is HIF-1 the missing link? (2011)

Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and colleagues report that tissue hypoxia resulting in dysfunctional airway microvasculature precedes the airway fibrosis characteristic of OB. In addition, a relative deficiency of allograft endothelial cell-derived HIF-1α contributes to this process. Data showing that overexpressing HIF-1α restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis.
Treebanks: Linking Linguistic Theory to Computational Linguistics (2012)

Treebanks are language resources that provide annotations at various levels of linguistic structure starting from the word level. They typically provide syntactic constituent or dependency structures for sentences, but increasingly extend to annotation beyond syntactic structure, including semantic, pragmatic and rhetorical annotation, or go beyond a single language, as in parallel treebanks.&#x0D; Experience in building treebanks has shown that there is a close relation between formal linguistic theory and the design and practice of annotation. With increasing complexity of annotations, the design of annotation schemes becomes more and more theory-dependent. At the same time, linguistically motivated treebank annotations have become crucially important for the development of data-driven approaches to natural language processing and for linguistic research in general.&#x0D; Treebanks therefore constitute an important link between linguistic theory and computational linguistics.&#x0D; The International Workshop on Treebanks and Linguistic Theories provides a forum for researchers working on treebanks from both perspectives. The present volume presents the contents of the 10th edition of this workshop series, held in 2012 at the University of Heidelberg.
Applying PCA for Traffic Anomaly Detection: Problems and Solutions (2009)

Spatial Principal Component Analysis (PCA) has been proposed for network-wide anomaly detection. A recent work has shown that PCA is very sensitive to calibration settings. Unfortunately, the authors did not provide further explanations for this observation. In this paper, we fill this gap and provide the reasoning behind the found discrepancies. We revisit PCA for anomaly detection and evaluate its performance on our data. We develop a slightly modified version of PCA that uses only data from a single router. Instead of correlating data across different spatial measurement points, we correlate the data across different metrics. With the help of the analyzed data, we explain the pitfalls of PCA and underline our argumentation with measurement results. We show that the main problem is that PCA fails to capture temporal correlation. We propose a solution to deal with this problem by replacing PCA with the Karhunen-Loeve transform. We find that when we consider temporal correlation, anomaly detection results are significantly improved.
A novel biotinylated degradable polymer for cell-interactive applications (1998)

We describe the development of a novel biodegradable polymer designed to present bioactive motifs at the surfaces of materials of any architecture. The polymer is a block copolymer of biotinylated poly(ethylene glycol) (PEG) with poly(lactic acid) (PLA); it utilizes the high-affinity coupling of the biotin-avidin system to undergo postfabrication surface engineering. We show, using surface plasmon resonance analysis (SPR) and confocal microscopy that surface engineering can be achieved under aqueous conditions in short time periods. These surfaces interact with cell surface molecules and generate beneficial responses as demonstrated by the model study of integrin-mediated spreading of endothelial cells on polymer surfaces presenting RGD peptide adhesion sequences.
Reactivity of Bi-Sr-Ca-Cu-O superconductor surface with indium studied by photoelectron spectroscopy (1989)

Interfacial interaction between Bi2Sr2CaCu2O8+δ high Tc superconductor and indium metal has been investigated using photoemission measurements. The results indicate that a sharp interface is possible and the interfacial interaction is restricted to a region of ∼5 Å thickness. In this region, there is a substantial CuO and SrO bond breaking.
PM378 Connexin45 Over-Expression Causes Arrhythmia in Rat Hearts (2014)

Despite the rarity of epidermoid cysts in the chiasmatic region, their surgical treatment is particularly complicated because of the tendency toward massive dissemination of the epidermoid masses along cerebrospinal fluid pathways and significant deviation of the tumor from the midline.The purpose of the present work is evaluation of the role of extended transsphenoidal endoscopic endonasal approaches in the surgery of epidermoid cysts.The study included 6 patients with epidermoid cysts in the chiasmatic region who were operated on at the Burdenko Neurosurgery Institute in the last 5 years using an anterior extended transsphenoidal endoscopic endonasal approach.The epidermoid masses were totally removed in 5 patients, but in no patient was it possible to completely remove the epidermoid cyst capsule. Visual deterioration was not noted in any patient, nor did new focal neurologic symptoms appear. One of the patients developed hypopituitary disorders in the postoperative period. No recurrence of the epidermoid cysts was observed during the follow-up period.Removal of epidermoid cysts in the chiasmatic region using an anterior extended transsphenoidal endoscopic approach may be an alternative to transcranial microsurgery operations. This technique is widely accepted as an approach to this area.
Recent advances with the electrostatically focused high power amplifier klystrons (1963)

In an electrostatically focused klystron (ESFK) the electron beam is focused by a periodic system of electrostatic lenses. These lenses are formed by the walls of successive cavities and a ring shaped electrode located between adjacent cavities. The latest model of the ESFK employs a solid beam of circular cross section having a perveance of 0.7 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> a/v <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3/2</sup> . By a proper choice of lens dimensions, optimum operating performance of the tube is achieved with the lens voltages equal to cathode voltage. The tube incorporates four cavities and is of all metal-ceramic construction. Cavities and collector are water-cooled. The rf output coupler is a standard wave-guide flange containing a beryllia window. At the present moment, the tube which was designed for an average power output of 5 kw is still being tested. With a beam voltage of 25 kv, and a frequency of 2.8 Gc, the following, results have been achieved to date: Power output 28 kw peak Saturated gain 30 db Small Signal Gain > 67 db Saturated efficiency 41% All measurements were taken at a duty cycle of 0.003. With a previous model of the ESFK, which was limited only by the power handling capability of the coaxial rf window, an average rf output power of 850 watts was achieved.
Effect of Beam Hardening on Arterial Enhancement in Thoracoabdominal CT Angiography with Increasing Patient Size: An in Vitro and in Vivo Study (2010)

Beam hardening may substantially contribute to reduced arterial enhancement in larger patients undergoing thoracoabdominal CT angiography. The beam-hardening effect on arterial enhancement is more pronounced at higher tube voltages.
Power system harmonic analysis using the Kalman filter (2004)

This paper explores the practical application of the Kalman filter to the analysis of harmonic levels in power systems. The merits and limitations of different possible implementations are investigated and the effect of fundamental frequency variation is examined. The tuning of the Kalman filter for desired dynamic response is discussed and an adaptive tuning algorithm derived for the improved convergence of nonlinear models. The effectiveness of the resulting schemes are tested under a variety of typical power system operating conditions.
Subcellular Fractionation of Brain Tissue Using Free-Flow Electrophoresis (2011)

Accurate annotation of protein identifications in organellar proteomics highly depends on the sample quality with special respect to contaminations from other subcellular compartments. In this respect, Free-flow electrophoresis (FFE) offers a valuable alternative to classical centrifugation techniques, since it relies on quite different physical parameters. During the last years, FFE has been successfully used for the separation of various organelles from different tissues, yet is largely unknown in the field of neurobiology. Here we present two separation schemes for the fractionation of a synaptic preparation from rat brain using different modes of FFE. Isotachophoresis (ITP), a focusing technique separating organelles according to their electrophoretic mobilities, was able to distribute the synaptosome sample into different subfractions: mitochondrial cross contaminations showed the highest electrophoretic mobility and migrated nearest to the anode of the FFE instrument; proximate to these, proteins of the presynaptic compartment accumulated, whereas nearest to the cathode of the instrument postsynaptic marker proteins were predominantly found. As a nonfocusing technique, zonal FFE does not possess a separation capacity comparable to ITP; however, due to a continuous separation mode, it is adapted to process higher sample amounts and can be used for large-scale separations. We applied zonal FFE to the same starting material as in ITP and were able to separate mitochondria from synaptic material of the preparation, thus offering a fast alternative to clean synaptosome preparations from residual mitochondrial contaminations.
Very strong low temperature bainite (2002)

Bainite has been obtained by heat treatment at temperatures as low as 125°C in a high carbon, high silicon steel. This has had the effect of greatly refining the microstructure, which is found to have a strength in excess of 2·5 GPa together with an ability to flow plastically before fracture. Such properties have never before been achieved with bainite. In this paper metallographic details are reported of the very fine bainitic microstructure associated with the incredibly low transformation temperature, where during the time scale of the experiments, an iron atom cannot diffuse over a distance greater than ∼10-17 m. Yet, the microstructure has a scale in the micrometre range, consistent only with a displacive mechanism of transformation. © 2002 IoM Communications Ltd.
Supplementary Table S2 from Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study (2023)

&lt;p&gt;Summary of noncompartmental pharmacokinetic parameters following intravenous infusion of LY3022855.&lt;/p&gt;
Producing Protein Microarrays from DNA Microarrays (2011)

The development of protein microarrays makes possible interaction-based protein assays in miniaturised, multiplexed formats. A major requirement determining their uptake and use is the availability and stability of purified, functional proteins for immobilisation. With conventional methods, involving individual expression and purification of recombinant proteins, the cost of commercial high-content protein arrays is often found to be prohibitively high. Moreover, due to the need for specialised microarray production equipment, custom-made protein arrays containing more focussed sets of proteins of interest are also in little use. In the DNA array to protein array technology described herein, repeated economical printing of protein microarrays from a reusable template DNA microarray is performed on demand by cell-free -protein synthesis. Once the template DNA microarray has been obtained, protein microarrays are made using purely macro-handling procedures, making protein arraying accessible without sophisticated microarraying apparatus.
THE IMPACT OF SEROLOGIC TESTING FOR HEPATITIS C VIRUS AND SYPHILIS IN THE SELECTION OF DONOR CORNEAL TISSUE (1994)

Simon, Mark W.1; Pflugfelder, Stephen C.1; Li, Xiuming2; Taylor, Mary Ann1; Curtin, Victor T.Author Information
Front Cover Picture: Thiosulfonates as Emerging Reactants: Synthesis and Applications (Adv. Synth. Catal. 1/2020) (2020)

The front cover picture, designed by Bert Maes and co-workers, illustrates the current synthetic strategies towards thiosulfonates. Interestingly, these sulfur reactants are a very powerful class of sulfenylating reactants based on their ability to react with nucleophiles, electrophiles and radicals. Further details of this work can be found in the review on pages 3–64 (P. Mampuys, C. R. McElroy, J. H. Clark, R. V. A. Orru, B. U. W. Maes, Adv. Synth. Catal. 2020, 362, 3–64; DOI: 10.1002/adsc.201900864).
Block and Graft Copolymers Containing Poly(dimethylsiloxane) and Poly(4-vinyl-pyridine) Segments by Free Radical Polymerization (2003)

Polysiloxanes with terminal or pendent aldehyde functionality can be used as components of copper salt-based redox initiation systems to prepare block, graft and crosslinked copolymers containing poly(4-vinylpyridine) and polysiloxane segments. The block and graft copolymers form very viscous solutions in dilute HCl and have useful anti-foam activity.
On-line determination of reduced-order models of linear systems via the moving discrete Fourier transform (MDFT) (2003)

A method for online determination of reduced-order models (ROM) of stable linear systems is presented. The identification method utilizes the moving discrete Fourier transform (MDFT) to monitor continuously the frequency-domain profile of the system input and output. The input and output MDFTs are used to determine the effect of the system on n (for an nth-order ROM) sinusoidal components in these signals, although the plant input and output need not actually be sinusoidal. The MDFT is computationally more efficient than standard FFT algorithms, when the DFT of an evolving time signal is desired.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 4 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy (2023)

Supplementary Figure 4 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
A Sinusoidal Pulsewidth Modulation (SPWM) Technique for Capacitor Voltage Balancing of a Nested T-Type Four-Level Inverter (2018)

In this letter, a new control method based on the sinusoidal pulsewidth modulation scheme is proposed to control capacitor voltages of a T-type four-level nested neutral-point-clamped (NNPC) inverter. The T-type four-level NNPC inverter has a lower number of switches and components compared with other four-level classic and advanced inverters, which make this topology attractive for high-power medium-voltage applications. This topology has been proposed and studied with the assumption of constant dc sources instead of flying capacitors. In this letter, a simple single-phase modulator is developed to balance flying capacitor voltages. The performance and the feasibility of the proposed control technique are evaluated experimentally under a steady-state and transient conditions and for different modulation indexes and loads. The experimental results demonstrate the effectiveness of the developed control method to control the capacitors' voltages.