gebhart/patrepeval huggingface dataset:
USE OF CIRCULAR DICHROISM TO STUDY THE INTERACTIONS OF CARBOXYPEPTIDASE A (ANSON) AND A/sub $alpha$+$beta$/ WITH SUBSTRATES AND INHIBITORS (1971)

they contribute approximately 10 percent of the total CD intensity at 277 nm (epsilon/sub L/ - epsilon/sub R/ = -0.36 M/sup -1/cm/sup -1/ per tyrosyl). Disulfide bonds in BBI also have a broad positive CD band centered around 240 nm (epsilon/sub L/ - epsilon/sub R/ = 0.9 M/sup -1/cm/sup -1/ per disulfide). Tyrosyl side chains give rise to a sharp positive peak at 231 nm, overlapping with the positive disulfide CD. Dimerization of monomeric BBI did not alter the CD profile. Fully acetylated BBI has the near ultraviolet disulfide CD and the far ultraviolet polypeptide CD very similar to those of the native inhibitor, indicating that O-acetylation of two tyrosyl side chains did not induce much conformational change in BBI. The near ultraviolet CD of BBI was altered in the presence of 8 M urea or 6 M guanidine hydrochloride, with a greater change brought about by the latter. Dithiothreitol (20 mM) completely abolished the tyrosyl and disulfide CD in this region. (auth)
Online Sol-gel Capillary Microextraction-Mass Spectrometry (CME-MS) Analysis of Illicit Drugs (2019)

Providing rapid and sensitive sample cleanup, sol-gel capillary microextraction (CME) is a form of solid phase microextraction (SPME). The capillary format of CME couples easily with mass spectrometry (MS) by employing sol-gel sorbent coatings in inexpensive fused silica capillaries. By leveraging the syringe pump and six-port valve readily available on the commercial MS, we can obviate the need for chromatography for samples as complex as urine in quantitative assays. Two different sol-gel materials were studied as microextraction sorbents: one with a single ligand of octadecyl (C<sub>18</sub>) and the other with a dual-ligand combination of C<sub>18</sub> and phenyl (Phe) groups. The CME-MS method was optimized for flow rate and solvent desorption and studied for overall microextraction performance between the two sorbents studied. We extract illicit drugs including cocaine, heroin, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, and oxycodone, proving good run-to-run reproducibility (RSD% < 10%) and low detection limits (< 10 ng mL<sup>-1</sup>). The dual-ligand sorbent demonstrated superior performance due to typical hydrophobic properties of C<sub>18</sub> as well as potential π-π interactions of the Phe functionality and the aromatic moiety common to many drugs. This study demonstrates the advantage of fine-tuning sol-gel sorbents for application-specific CME-MS. We apply our method to the analysis of various drugs in synthetic and human urine samples and show low carryover effect (~ 5%) and low matrix effect in the presence of the urine matrix. Thus, the sol-gel CME-MS technique described herein stands to be an attractive alternative to other SPME-MS techniques.
Electrochemical Methods of Transference Number Determination for Polymer Electrolyte Systems: A Comparative Study (2022)

The transference number for cations, t + , is one of the most important parameters for characterizing polymeric and/or composite solid electrolytes. It expresses the contribution of the positive charge carriers to the total conductivity, which in turn reflects the degree of polarization due to the negative carriers in the electrolyte systems. Four electrochemical methods based on different equations commonly used for obtaining t + are compared. A series of experiments were conducted with solid polymer electrolytes based on polyethylene oxide with and without TiO 2 ceramic additive. Interestingly, the oldest method developed and presented four decades ago, emerges as the most simple, reliable, sensitive, repeatable, and stable option for determining t + values over time.
Automatic Parameter Configuration for Inventory Management in SAP ERP/APO (2010)

Companies today generally hold several thousands SKUs (stock-keeping units) in stock. With an ever increasing trend towards highly customized products, the number of SKUs held by companies is likely to increase even more in the future. For each of the SKUs held in stock, a decision has to be made on how to configure each module of the SKU’s inventory system. Doing this for each SKU individually seems to be an unfeasible task, given the large numbers of SKUs held in stock by most companies. Therefore, these companies configure inventory systems not on a SKU-basis but on a group basis, where the groups are usually determined using an ABC/XYZ analysis. The configuration using such a rough group basis for several thousand SKUs does not allow for individually customized inventory systems and therefore might not exploit the implemented inventory methods in a software package in an optimal way. In this research project, decision systems allowing an automated inventory system configuration in SAP ERP and SAP APO at the SKU-level are developed. The SAP ERP corporate software package is the market leader for Enterprise Resource Planning systems, offering a wide range of inventory methods for the relevant inventory system modules. The advanced planning and scheduling system of SAP, Advanced Planning and Optimization (APO), provides additional inventory methods that can be chosen for the configuration in the inventory system modules. Keywords: material resource planning, SAP ERP/APO, inventory management, parameter configuration
Evaluation of the Mechanical Properties of Microcapsule-Based Self-Healing Composites (2016)

Self-healing materials are beginning to be considered for applications in the field of structural materials. For this reason, in addition to self-healing efficiency, also mechanical properties such as tensile and compressive properties are beginning to become more and more important for this kind of materials. In this paper, three different systems based on epoxy-resins/ethylidene-norbornene (ENB)/Hoveyda-Grubbs 1st-generation (HG1) catalyst are investigated in terms of mechanical properties and healing efficiency. The experimental results show that the mechanical properties of the self-healing systems are mainly determined by the chemical nature of the epoxy matrix. In particular, the replacement of a conventional flexibilizer (Heloxy 71) with a reactive diluent (1,4-butanediol diglycidyl ether) allows obtaining self-healing materials with better mechanical properties and higher thermal stability. An increase in the curing temperature causes an increase in the elastic modulus and a slight reduction of the healing efficiency. These results can constitute the basis to design systems with high regenerative ability and appropriate mechanical performance.
Synthesis and antiinflammatory evaluation of certain 5-alkoxy-2,7-dialkyltryptamines (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiinflammatory evaluation of certain 5-alkoxy-2,7-dialkyltryptaminesJohn F. Poletto, George R. Allen Jr., Adolf E. Sloboda, and Martin J. WeissCite this: J. Med. Chem. 1973, 16, 7, 757–765Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jm00265a004https://doi.org/10.1021/jm00265a004research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes (2017)

High-grade chloroquine (CQ) resistance has emerged in both <i>Plasmodium falciparum</i> and <i>P. vivax</i> The aim of the present study was to investigate the phenotypic differences of CQ resistance in both of these species and the ability of known CQ resistance reversal agents (CQRRAs) to alter CQ susceptibility. Between April 2015 and April 2016, the potential of verapamil (VP), mibefradil (MF), L703,606 (L7), and primaquine (PQ) to reverse CQ resistance was assessed in 46 <i>P. falciparum</i> and 34 <i>P. vivax</i> clinical isolates in Papua, Indonesia, where CQ resistance is present in both species, using a modified schizont maturation assay. In <i>P. falciparum</i>, CQ 50% inhibitory concentrations (IC<sub>50</sub>s) were reduced when CQ was combined with VP (1.4-fold), MF (1.2-fold), L7 (4.2-fold), or PQ (1.8-fold). The degree of CQ resistance reversal in <i>P. falciparum</i> was highly correlated with CQ susceptibility for all CQRRAs (<i>R</i><sup>2</sup> = 0.951, 0.852, 0.962, and 0.901 for VP, MF, L7, and PQ, respectively), in line with observations in <i>P. falciparum</i> laboratory strains. In contrast, no reduction in the CQ IC<sub>50</sub>s was observed with any of the CQRRAs in <i>P. vivax</i>, even in those isolates with high chloroquine IC<sub>50</sub>s. The differential effect of CQRRAs in <i>P. falciparum</i> and <i>P. vivax</i> suggests significant differences in CQ kinetics and, potentially, the likely mechanism of CQ resistance between these two species.
Metafora: A Web-Based Platform for Learning to Learn Together in Science and Mathematics (2013)

This paper presents Metafora, both a platform for integrated tools as well as an emerging pedagogy for supporting Learning to Learn Together in science and mathematics education. Our goal is to design technology that brings education to a higher level; a level where students not only learn subject matter, but also gain a set of critical skills needed to engage in and self-regulate collaborative learning experiences in science and math education. To achieve this goal, we need to understand how educational technology can bring students' attention to, and promote these higher level skills. We first discuss the core skills that students need as they learn to learn together. We then present a platform and pedagogy to support the acquisition of the critical skills. Finally, we present an example use of our system based on results from pilot studies. This example demonstrates interaction with the platform to highlight potential benefits and limitations of our approach to promoting the associated skills.
Experimental trial on surgical treatment for transverse fractures of the proximal phalanx: technique using intramedullary conical compression screw versus lateral compression plate (2015)

Stabilization using the Acutrak(®) screw for treating fractures in the model used in this trial presents mechanical results that are statistically significantly superior to those from the axial compression technique using the lateral plate (Aptus Hand(®)).
Robotic assessment of manual asymmetries in unimanual and bimanual wrist joint position sense (2016)

Despite being so similar from a biomechanical perspective, the left and the right arms develop with different dexterity and important functional differences. This asymmetry in motor performance, most commonly known as handedness, has been extensively investigated in numerous research. However, whether such a dominance exists in the proprioceptive system remains unclear. To this end, manual asymmetries in proprioceptive sensitivity were examined in fourteen neurologically healthy right-handed individuals, with a unimanual and bimanual robot-aided wrist joint position matching (JPM) task, whereby they are required to replicate a reference wrist angle in the absence of vision. The results did not provide any evidence of manual asymmetries in proprioceptive acuity but some indication of asymmetry was singled out in motor execution, with smoother movement trajectories when the task was performed by the non dominant hand. In contrast, experimental conditions (unimanual vs. bimanual) appeared to influence proprioceptive acuity as well as movement kinematics: in the unimanual condition proprioceptive acuity was higher and more consistent and, despite the fact that movements were found to be faster in the unimanual task, they resulted smoother if performed with two hands at the same time. In sum, our results indicated that while there was a decrement in performance during bimanual tasks, there was no evidence of proprioceptive hand dominance”.
Assessment of biofilm cell removal and killing and biocide efficacy using the microtiter plate test (2007)

Biofilm formation on surfaces has serious economic and environmental implications. Growth of biofilm within a water distribution system can lead to problems such as biocorrosion and biofouling accumulation. To prevent and control these occurrences, it is necessary to use suitable biocides to remove the biofilm and kill biofilm cells. In this study, the genera Actinobacillus, Branhamella, Bacillus, Micrococcus and Acinetobacter were isolated from biofilms formed on brass coupons exposed to a cooling water system. It was shown by the microtiter plate test that a mixed culture of the isolates and a single culture of Acinetobacter sp(2) produced high levels of biofilm formation. A microwell plate technique was applied for assessment of the ability of various biocides to remove and kill mixed-culture biofilm cells and Acinetobacter sp(2), the latter as a single-species biofilm with a high rate of biofilm production. The results showed that the mixed-culture biofilm cells had more resistance to removal and killing by some biocides, such as hydrogen peroxide and sulfathiazole, than the single-species biofilm cells (Acinetobacter sp(2)). Oxidising biocides, such as sodium hypochlorite and hydrogen peroxide, demonstrated a higher potential for biofilm removal and killing compared with non-oxidising biocides (sulfathiazole and glutaraldehyde).
Faculty Opinions recommendation of Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. (2004)

Rho family GTPases, particularly Rac1 and Cdc42, are key regulators of cell polarization and directional migration. Adenomatous polyposis coli (APC) is also thought to play a pivotal role in polarized cell migration. We have found that IQGAP1, an effector of Rac1 and Cdc42, interacts directly with APC. IQGAP1 and APC localize interdependently to the leading edge in migrating Vero cells, and activated Rac1/Cdc42 form a ternary complex with IQGAP1 and APC. Depletion of either IQGAP1 or APC inhibits actin meshwork formation and polarized migration. Depletion of IQGAP1 or APC also disrupts localization of CLIP-170, a microtubule-stabilizing protein that interacts with IQGAP1. Taken together, these results suggest a model in which activation of Rac1 and Cdc42 in response to migration signals leads to recruitment of IQGAP1 and APC which, together with CLIP-170, form a complex that links the actin cytoskeleton and microtubule dynamics during cell polarization and directional migration. PMID: 15572129
The catalytic activity of apoferritin (1972)

Research Article| November 01 1972 The catalytic activity of apoferritin R R Crichton; R R Crichton 1Max-Planck-Institut far Molekulare Genetik, Berlin 33, Ihnestrasse 63-73, German Federal Republic and Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar C F Bryce C F Bryce 1Max-Planck-Institut far Molekulare Genetik, Berlin 33, Ihnestrasse 63-73, German Federal Republic and Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1972 The Biochemical Society1972 Biochem J (1972) 130 (1): 36P. https://doi.org/10.1042/bj1300036Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation R R Crichton, C F Bryce; The catalytic activity of apoferritin. Biochem J 1 November 1972; 130 (1): 36P. doi: https://doi.org/10.1042/bj1300036Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
What’s new in urology (2004)

∗Wake Forest Institute for Regenerative Medicine and Department of Urology, Wake Forest University School of Medicine, Winston-Salem, NC, USA Correspondence address: Anthony Atala, MD, Wake Forest Institute for Regenerative Medicine and Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157 USA Submitted and accepted May 6, 2004.
Limited efficacy of imatinib in severe pulmonary chronic graft-versus-host disease (2009)

To the editor:

We read with interest that Olivieri et al[1][1] observed complete or partial responses to imatinib 100 or 200 mg daily with improvement of lung function in 7 of 11 patients (64%) with pulmonary chronic graft-versus-host disease (cGVHD) of mild severity (lung function score [LFS] of
1024. An Oncolytic Conditionally Replicating Adenovirus for Hormone-Dependent and Hormone-Independent Prostate Cancer (2005)

The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a replicating adenovirus, Ad[I/PPT-E1A], where E1A gene expression is controlled by a recombinant regulatory sequence designated PPT. The PPT sequence comprises a PSA enhancer, a PSMA enhancer and a TARP promoter and it is shielded from transcriptional interference from adenoviral backbone sequences by an H19 insulator. Ad[I/PPT-E1A] yields prostate-specific E1A protein expression, viral replication and cytolysis in vitro. Furthermore, Ad[I/PPT-E1A] considerably regresses the growth of subcutaneous LNCaP prostate tumors in nude mice. Importantly, viral replication and cytolytic effect of Ad[I/PPT-E1A] are independent on the testosterone levels in the prostate cancer cell. This may be beneficial in a clinical setting since many prostate cancer patients are treated with androgen withdrawal. In conclusion, Ad[I/PPT-E1A] may prove to be useful in the treatment of localized prostate cancer.
Evaluation of Electrostatic Potential Induced by Anion-Dominated Partition into Zwitterionic Micelles and Origin of Selectivity in Anion Uptake (2000)

The surface potentials of n-dodecyltrimethylammoniopropanesulfonic acid (DDAPS) micelles in various electrolytes have been evaluated by capillary electrophoresis. This zwitterionic micelle has an inner cationic surface and an outer anionic surface and accommodates anions better than cations, indicating that a negative surface potential is induced by anion-dominated partition. Selectivity terms, i.e., solvation changes of ions and ion association between ions and charged groups in the DDAPS micelles, are introduced into the Poisson−Boltzmann equation for the spherical geometry. This model allows the interpretation of differences in the ionic partition and surface potential between electrolytes. The selectivity parameters have been determined by assuming agreement between the zeta potential determined by capillary electrophoresis and the calculated outer surface potential of the micelle. The obtained selectivity parameters can also explain the potentiometrically evaluated partition of ClO4- and I-. It has been confirmed that capillary electrophoresis has wide applicability in surface potential measurements and can detect surface potentials of less than 1 mV. The selectivity origin in the partition into the DDAPS micelles is also discussed on the basis of evaluated parameters. The hydration changes mainly govern the uptake of well-hydrated anions, whereas poorly hydrated anions are partitioned into the micelle principally by ion-pair formation with the cationic groups in the micelles.
The Women’s Health Initiative Memory Study (WHIMS) (1998)

Evidence from animal, human cross-sectional, case-control, and prospective studies indicate that hormone replacement therapy (HRT) is a promising treatment to delay the onset of symptoms of dementia. The Women's Health Initiative Memory Study (WHIMS) is the first double-masked, randomized, placebo-controlled, long-term clinical trial designed to test the hypothesis that HRT reduces the incidence of all-cause dementia in women aged 65 and older. WHIMS, an ancillary study to the Women's Health Initiative (WHI) funded by the National Institutes of Health, will recruit a subgroup of women aged 65 and older from among those enrolling in the HRT trial of the WHI. The WHI clinical centers and 10 affiliated satellites plan to enroll approximately 8300 women into WHIMS over a 2-year period. Participants will be followed annually for 6 years, receiving cognitive assessments via the Modified Mini-Mental State (3MS) Examination. Women who screen positively for cognitive impairment on the basis of an educational and age-adjusted 3MS cutpoint proceed to more extensive neuropsychological testing and neurologic evaluation. Each woman suspected to have dementia then undergoes a series of laboratory tests that confirm the clinical diagnosis and classify the type of dementia. WHIMS is designed to provide more than 80% statistical power to detect a 40% reduction in the rate of all-cause dementia, an effect that could have profound public health implications for older women's health and functioning.
The Winner's Curse, Reserve Prices, and Endogenous Entry: Empirical Insights from eBay Auctions (2003)

No abstract.
Long Term Evaluation of Glass Composites for Use as a Reliable SOFC Sealing Material. (2006)

Abstract not provided.