gebhart/patrepeval huggingface dataset:
Quantum measurement as dissipation in chaotic atomic systems (1987)

It is argued through examples that for quantum non-linear Hamiltonians for atomic systems the main effect of measurement is the introduction of dissipation. In the dissipative case quantum measurements can be performed which lead to no disturbance of the system.
On the growth of the thermally modified non-resonant streaming instability (2020)

ABSTRACT The cosmic rays non-resonant streaming instability is believed to be the source of substantial magnetic field amplification. In this work, we investigate the effects of the ambient plasma temperature on the instability and derive analytical expressions of its growth rate in the hot, demagnetized regime of interaction. To study its non-linear evolution, we perform hybrid-PIC simulations for a wide range of temperatures. We find that in the cold limit, about two-thirds of the cosmic rays drift kinetic energy is converted into magnetic energy. Increasing the temperature of the ambient plasma can substantially reduce the growth rate and the magnitude of the saturated magnetic field.
Ripple feedback filter suitable for analog/digital mixed-mode audio amplifier for improved efficiency and stability (2003)

A new ripple feedback filter is presented for analog/digital mixed-mode amplifier (MMA) among audio applications. MMA is composed of two amplifiers: one is analog amplifier responsible for high fidelity and the other is digital switching amplifier in charge of high efficiency. To improve both total harmonic distortion (THD) and efficiency, a passive RLC filter is needed at the output side of the digital switching amplifier. A conventional filter, however, causes phase delay, which worsens current loop stability and makes the normal operation of MMA impossible. A ripple feedback filter is newly suggested to solve this problem, obtaining excellent efficiency and low THD.
Graphene Oxide as an Ideal Substrate for Hydrogen Storage (2009)

Organometallic nanomaterials hold the promise for molecular hydrogen (H(2)) storage by providing nearly ideal binding strength to H(2) for room-temperature applications. Synthesizing such materials, however, faces severe setbacks due to the problem of metal clustering. Inspired by a recent experimental breakthrough ( J. Am. Chem. Soc. 2008 , 130 , 6992 ), which demonstrates enhanced H(2) binding in Ti-grafted mesoporous silica, we propose combining the graphene oxide (GO) technique with Ti anchoring to overcome the current synthesis bottleneck for practical storage materials. Similar to silica, GO contains ample hydroxyl groups, which are the active sites for anchoring Ti atoms. GO can be routinely synthesized and is much lighter than silica. Hence, higher gravimetric storage capacity can be readily achieved. Our first-principles computations suggest that GO is primarily made of low-energy oxygen-containing structural motifs on the graphene sheet. The Ti atoms bind strongly to the oxygen sites with binding energies as high as 450 kJ/mol. This is comparable to that of silica and is indeed enough to prevent the Ti atoms from clustering. Each Ti can bind multiple H(2) with the desired binding energies (14-41 kJ/mol-H(2)). The estimated theoretical gravimetric and volumetric densities are 4.9 wt % and 64 g/L, respectively.
Primary squamous cell carcinoma of the main hepatic bile duct. (2008)

iliary malignant tumours represent less than 1% of all neoplastic processes in North America. Most of them are of adenocarcinomatous type; only 2% of biliary neoplasms are of squamous cell origin. Although 20 cases of squamous cell carcinoma of the biliary tree have been reported, only 6 cases were well documented. 1,2 We report a case of primary squamous cell carcinoma at the bifurcation level that may be only the second such case published in the literature. 1,3 We describe the clinical presentation and surgical procedure and discuss the current imaging modalities and therapy recommended for the management of this rare condition.
Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study (2019)

Combination sequential therapy improved survival in our cohort.
An improved method for computing q-values when the distribution of effect sizes is asymmetric (2014)

The R code and data files for the proposed method and examples are available at Bioinformatics online.
Determination of the Complex Index of Refraction of Rocks and Minerals (1969)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. G. Egan and J. F. Becker, "Determination of the Complex Index of Refraction of Rocks and Minerals," Appl. Opt. 8, 720-721 (1969) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
CredEx: user-centric credential management for grid and Web services (2005)

User authentication is a crucial security component for most computing systems. But since the security needs of different systems vary widely, authentication mechanisms are similarly diverse. In particular, independently-managed Web and grid services vary with regard to the type of security token (credential) used to prove user identity (username/password, X.509 signing, Kerberos, etc.). Forcing users to manage and present credentials manually for each service is tedious, error-prone and potentially insecure. In contrast, we present CredEx, an open-source, standards-based Web service that facilitates the secure storage of credentials and enables the dynamic exchange of different credential types using the WS-Trust token exchange protocol. With CredEx, a user can achieve single sign-on by acquiring a single (default) credential then dynamically exchanging that credential as needed for services that authenticate a different way. We describe the design and implementation of CredEx by focusing on its use in bridging password-based Web services and PKI-based grid services, illustrating how interoperability between these realms can be based upon the WS-Security and WS-Trust specifications.
ChemInform Abstract: REGIOSELECTIVE ALLYLATION OF METHOXY‐P‐BENZOQUINONE BY TRANS‐CINNAMYLTRIMETHYLTIN. CONTROL OF REGIOCHEMISTRY OF ALLYLATION BY USE OF A LEWIS ACID AND SYNTHESIS OF (.+‐.)‐4‐METHOXYDALBERGIONE (1981)

Abstract OEt 2 and Synthesis of (i)‐4‐Methoxydalbergione.
Contribution of Structural Genomics to Understanding the Biology ofEscherichia coli (2003)

Peer reviewed: Yes
Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction (2009)

Adding surgical ventricular reconstruction to CABG reduced the left ventricular volume, as compared with CABG alone. However, this anatomical change was not associated with a greater improvement in symptoms or exercise tolerance or with a reduction in the rate of death or hospitalization for cardiac causes. (ClinicalTrials.gov number, NCT00023595.)
The Inactivation of Methionine Synthase in Isolated Rat Hepatocytes by Sodium Nitroprusside (1997)

Methionine synthase, the enzyme that catalyses the transfer of a methyl group from 5-methyl tetrahydrofolate to homocysteine via the cofactor methylcobalamin, is one of the two established mammalian enzymes that utilise a biologically active vitamin B-12 derivative. Through its substrates, products and downstream metabolites, methionine synthase is directly involved in the sulphur amino acid pathways, polyamine biosynthesis, biological methylations and one-carbon-unit transfers. Rat liver methionine synthase was shown to be inactivated by the nitric oxide donor sodium nitroprusside. The inactivation occurred during the treatment of isolated rat hepatocytes in a time-dependent and dose-dependent manner with an apparent IC50 value of 170 microM. Highly purified rat liver methionine synthase was inactivated in a partially irreversible manner with an apparent IC50 value of 10 microM. The inactivation has been attributed to nitric oxide released by sodium nitroprusside. Since biomolecules possessing transition state metals are targets for nitric oxide, the possibility of a nitric oxide-cobalamin interaction could explain the observed inactivation. Nitric oxide is directly involved in different aspects of liver metabolic functions both under physiological and pathological conditions like sepsis and inflammation. The nitric-oxide-induced inactivation of methionine synthase could offer a rational explanation for the cellular and cytotoxic effects of this highly reactive molecule.
Factors Released from Cholestatic Rat Livers Possibly Involved in Inducing Bone Marrow Hepatic Stem Cell Priming (2008)

Previous studies have shown that bone marrow beta 2m(-)/Thy-1+ hepatic stem cells (BMHSCs) were able to engraft in vivo and differentiate into functioning hepatocytes in vitro. Our transcriptomic profiling on BMHSCs derived from rats subjected to common bile duct ligation (CBDL) demonstrated CBDL-derived beta 2m(-)/Thy-1+ BMHSCs expressed hepatocyte-like genes and shared more commonly expressed genes with hepatocytes, suggesting that an "on-site" priming of BMHSCs into hepatocyte lineage was initiated under the condition of CBDL. In this paper, transcriptomic profiling was carried out on livers from rats with CBDL to identify candidate factors released from cholestatic livers possibly involved in the priming of BMHSCs using Affymetrix Rat Genome U34A arrays. In CBDL rat livers, 1,091 probe sets were differentially expressed, of which 188 up-regulated probe sets were annotated as "extracellular" components. Gene ontology analysis showed many up-regulated genes belonged to cytokines, chemokines and growth factors, including Il1b, Il18, Ptn, Spp1, Grn, Ccl2, Cxcl1, Pf4, Tgfb, and Tgfb3. Cell differentiation and proliferation regulation factors such as Dmbt1, Efna1, Lgals1, Lep, Pmp2, and Gas6 were also induced in CBDL livers. Furthermore, many proteolysis and peptidolysis genes such as Mmp2, Mmp12, Mmp14, and Mmp23 were up-regulated in CBDL livers. Gene expression profiling showed that many cytokine-, chemokine-, growth factor- as well as certain extracellular protein-related genes were induced in CBDL livers, suggesting that these genes may be involved in hepatic BMHSCs priming.
Translocation of protein kinase C isozymes in lactotroph-enriched rat anterior pituitary cell cultures: differential effects of substance P and phorbol ester (1994)

Translocation of protein kinase C (PKC) from the cytosol to the plasma membranes is believed to reflect activation of the enzyme. We have studied translocation of PKC in lactotroph-enriched anterior pituitary cell cultures by measuring the incorporation of gamma-32P from [gamma-32P]ATP into a synthetic peptide substrate, MBP4-14, and by immunoblotting of PKC isozymes. Using cells permeabilized with digitonin the effects of PKC cofactors on the distribution of the enzyme were studied. Ca2+ (50 nM) and dioctanoyl-sn-glycerol had no effect when tested alone, but in combination they caused a redistribution of PKC from the soluble to the particulate fraction. Arachidonic acid needed Ca2+ to induce translocation of PKC, while being ineffective under Ca(2+)-free conditions. Western blot analysis of partly purified PKC from lactotroph-enriched pituitary cells revealed the presence of the alpha, beta, delta and zeta isozymes. 12-O-Tetradecanoylphorbol 13-acetate (TPA) and substance P displayed different patterns of redistribution of PKC isozyme immunoreactivity from soluble to membrane-attached forms. Thus, TPA induced time- and dose-dependent (mean effective concentration (EC50) = 1 nM) translocation of the alpha, beta and delta species, while substance P stimulated time- and dose-dependent (EC50 = 1 nM) redistribution of the alpha and beta isozymes. zeta subtype immunoreactivity could not be translocated by either agonist; neither could the immunoreactivity of zeta be down-regulated by long-term treatment (24 h) with TPA. The results indicate that simultaneous activation of phospholipases C and A2 induces a synergistic activation of PKC. Finally it is suggested that substance P may exert some of its effects in lactotrophs by translocation of PKC isozymes alpha and beta.
[A case of adenoid cystic carcinoma presenting with stridor and which was treated by reversed gamma type stent placement]. (1998)

A 66-year-old man was admitted to Saiseikai Suita Hospital with stridor and dyspnea. The flow-volume curve showed central airway obstruction pattern. Although a P-A chest roentogenogram was normal, chest tomogram demonstrated a tumor shadow in the lower portion of the trachea. Chest CT examination demonstrated a tumor arising from the posterior wall of the lower portion of the trachea and stenosis with wall thickening extending from the lower portion of the trachea to both main bronchi. Bronchofiberscopic examination revealed polypoid tumors obstructing the lower portion of the tracheal lumen, and biopsy was subsequently performed. On the night immediately after the bronchofiberscopic examination, the patent suddenly choked, and emergency intubation was performed. Adenoid cystic carcinoma was diagnosed on biopsy and we decided to place a spiral Z-stent. A reversed gamma-type stent placement was used. The first spiral Z-stent extended from the trachea to the right main bronchus and the second spiral Z-stent was placed in the left main bronchus through the first stent. Following the spiral Z-stent placement radiotherapy was performed. Spiral Z-stent placement resulted in dilation of the stenotic trachea and both main bronchi.
Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities (2015)

The aims of this study were to complement the current knowledge on the antioxidative composition of alcohol extracts from the fruits of Lycium barbarum and to evaluate their antioxidant activities. Three new dimers of phenolic amides, named lyciumamides A (3), B (4), and C (5), together with two monomers, N-E-coumaroyl tyramine (1) and N-E-feruloyl tyramine (2), were isolated from the fruits for the first time with the help of activity-guided chromatography. Compounds 1-5 were evaluated for their antioxidant activities in scavenging 2,2-diphenyl-1-picrylhydrazyl free radical and inhibiting lipid peroxidation in rat liver microsomes induced by ascorbate/Fe<sup>2+</sup>, cumine hydroperoxide, or CCl<sub>4</sub>/reduced form of nicotinamide-adenine dinucleotide phosphate, and the results showed that all of them exhibited strong activities, whereas compounds 1 and 2 were more potent than the reference tert-butyl-4-hydroxyanisole.
Evaluation of Sub-micrometer-Sized Particles Generated from a Diesel Locomotive and Jackleg Drilling in an Underground Metal Mine (2020)

Concerns have been raised regarding small respirable particles, i.e. sub-micrometer-sized particles, associated with mining activities. This evaluation was designed to investigate the emissions from jackleg drilling and diesel engines and to characterize the nature of emitted particles using gravimetric analysis and number metrics. The mass concentration to which workers are potentially exposed was determined from a 4-h sampling in the vicinity of drilling activities in an underground metal mine; this concentration was found to be lower than 0.6 mg m-3 of total respirable dust. This mass concentration is low; however, the number concentrations of emitted particles from drilling exceeded 1 × 106 particles cm-3 in areas 7-9 m downwind from the drilling operation. Sub-micrometer-sized particles were also observed in aerosol samples collected using a specialized sampler, and various elements associated with drilling were found among these emitted particles. Finally, the particles in the diesel exhaust were collected, and the exhaust was found to contain nanometer-sized particles.
Camera speeds for optoelectronic assessment of stride-timing characteristics in horses at the trot. (1994)

Quantitated locomotion analysis is increasingly being used during assessment and treatment of gait disorders in human beings. Locomotion analysis is also thought to have potential for enhancing the assessment of lameness in horses. Availability of high-speed video recording systems has simplified the process of quantitated locomotion analysis; however, the high cost of such systems has limited their use for routine clinical assessment in horses. The temporal resolution of 500- to 1,000-images/s (Hz) recording systems is beyond what has been considered necessary for precise quantitation of short-duration events in horses at the trot; however, it is uncertain whether the temporal resolution of more economical 60-Hz recording systems is adequate. To determine whether a recording rate of 60 Hz is satisfactory for assessment of stride-timing values in horses at the trot, the stride-timing values calculated from 60-Hz recordings were compared with those calculated from 1,000-Hz recordings that had been simultaneously made for 5 horses trotting on a horizontal treadmill at a speed of 3.0 m/s. The left forefoot of each horse was fitted with an instrumented horseshoe that illuminated and quenched light-emitting diodes (LED) in view of both cameras precisely at toe contact, heel contact, heel lift, and toe lift. The exact pattern and timing of foot placement and lift was referenced by the illumination pattern of the LED. Recordings of 10 consecutive strides were reviewed, image by image for each horse, and the elapsed time at each important stride event was tabulated.(ABSTRACT TRUNCATED AT 250 WORDS)
Strategies for Virtual Optical Network Allocation (2011)

This paper presents Integer Linear Programming (ILP) formulations to optimally allocate Virtual Optical Networks (VONs) over a transparent optical network substrate. These formulations serve the purpose of building either completely transparent VONs or opaque ones, where electrical termination capabilities are assumed at each virtual network node. In addition, a lightweight Greedy Randomized Adaptive Search (GRASP) heuristic is provided for the transparent case. The obtained results validate the accuracy of the proposed heuristic and reveal the benefits of the presented solutions against simpler shortest-path-based VON allocation strategies.
Biochemical characterization of recombinant factor IX. (1998)

Mature human factor IX is a 55,000-d glycoprotein with a modular domain structure and numerous posttranslational modifications. A recombinant form of human factor IX (rFIX) has been produced from a Chinese hamster ovary cell line that was engineered for high-level protein processing and expression. To ensure that the recombinant molecule contains the requisite structural and functional features of the plasma-derived form, rFIX was subjected to detailed biochemical and biophysical characterization. The laboratory studies showed that the posttranslational modifications and primary, secondary, and tertiary structures of rFIX were similar to those of plasma-derived factor IX (pdFIX). In addition, rFIX displayed a high degree of purity and a product release specification for specific activity that is > or = 200 IU/mg.
Abstract P6-03-04: Microenvironment-induced epigenetic reprogramming imposes drug-tolerant states in breast cancer cells (2020)

Abstract Development of resistance to breast cancer (BC) therapy is frustratingly common. Multiple mechanisms of resistance have been identified including selection of genetic resistance, redundant signaling, and others. More recently, rare cancer cells were shown to be sporadically reprogrammed by the presence of anti-cancer drugs into transiently resistant states, then to expand later after cessation of therapy. We have demonstrated that the physical character and composition of tumor microenvironment (ME) components are determinants of BC cell drug resistance, however, the mechanism by which this phenomenon occurs is unclear. We hypothesize that epigenetic reprogramming is not rare or sporadic, indeed, that specific tumor ME components impose epigenetic states that beget the expression of gene clusters that put cancer cells into drug-tolerant states. Our current pharmacopeia targets cancer cells, not their ME. Some tumor ME components, e.g. extracellular matrices (ECM), have half-lives that span years, and growth factors with typically short half-lives can be stabilized by direct association with ECM. Thus, a ME-imposed drug tolerance mechanism would explain how resistance can arise rapidly, in multiple locations, without the need for genetic selection. Because ME-cell interactions lead to activation of specific pathways, based on canonical receptor-ligand models, we should be able to circumvent ME-imposed drug tolerance by addition of molecules that alter ME-induced signaling. Clusters of genes that are activated in multidrug resistant breast cancer cells identified potential markers of drug tolerance. ME-drivers of the drug tolerance markers were identified in high-throughput cell-based screens with the MicroEnvironment MicroArray (MEMA) platform. BC cells were exposed in parallel to over 1000 unique combinatorial MEs, which were chosen to mimic normal mammary gland, and luminal or basal BC tumor MEs. Single-cell resolution analysis revealed MEs that induce and maintain drug-tolerance markers. Longer-term functional experiments validated that the identified MEs also increased BC cells drug tolerance. Chromatin accessibility profiling with ATAC-sequencing demonstrated that BC cells cultured in those drug-tolerance inducing MEs exhibit chromatin opening in promoter regions of genes linked to epithelial plasticity (e.g. Axl, SNAI2, Vimentin, TWIST1) within 24h of exposure. These results support the concept that specific MEs drive drug-tolerant cellular phenotypes and suggest a novel interventional avenue for preventing acquired therapy resistance. Citation Format: Tiina A Jokela, Dustin Schones, Mark A LaBarge. Microenvironment-induced epigenetic reprogramming imposes drug-tolerant states in breast cancer cells [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-03-04.
Leu505 of Nox2 is crucial for optimal p67phox-dependent activation of the flavocytochromeb558 during phagocytic NADPH oxidase assembly (2006)

The role of Leu505 of Nox2 on the NADPH oxidase activation process was investigated. An X-CGD PLB-985 cell line expressing the Leu505Arg Nox2 mutant was obtained, exactly mimicking the phenotype of a previously published X91+-CGD case. In a reconstituted cell-free system (CFS), NADPH oxidase and iodonitrotetrazolium (INT) reductase activities were partially maintained concomitantly with a partial cytosolic factors translocation to the plasma membrane. This suggests that assembly and electron transfer from NADPH occurred partially in the Leu505Arg Nox2 mutant. Moreover, in a simplified CFS using purified mutant cytochrome b558 and recombinant p67phox, p47phox, and Rac1proteins, we found that the Km for NADPH and for NADH was about three times higher than those of purified WT cytochrome b558, indicating that the Leu505Arg mutation induces a slight decrease of the affinity for NADPH and NADH. In addition, oxidase activity can be extended by increasing the amount of p67phox in the simplified CFS assay. However, the maximal reconstituted oxidase activity using WT purified cytochrome b558 could not be reached using mutant cytochrome b558. In a three-dimensional model of the C-terminal tail of Nox2, Leu505 appears to have a strategic position just at the entry of the NADPH binding site and at the end of the alpha-helical loop (residues 484-504), a potential cytosolic factor binding region. The Leu505Arg mutation seems to affect the oxidase complex activation process through alteration of cytosolic factors binding and more particularly the p67phox interaction with cytochrome b558, thus affecting NADPH access to its binding site.