gebhart/patrepeval huggingface dataset:
An Optical Excursion from Micro-Fibers to Semiconductor Micro-Lasers (2003)

Our talk will start with a review of the first observation of a series of sharp peaks superimposed on the much broader fluorescence and spontaneous Raman peaks from a uranium oxide fiber and a regular optical fiber, respectively At first, these numerous and not all spectrally resolved sharp peaks were thought to be noise. Soon afterwards, these peaks were understood to be cavity enhanced spontaneous emission at particular wavelengths. Fibers can be treated as 2-d cavities. As is the case for 3-d cavities where Lorenz/Mie theory is used, all resonance peaks are referred to morphologydependent resonances (MDRs) or whispering gallery modes (WGMs) The WGMs are envisioned as standing waves, which can be decomposed into clockwise (CW) and counterclockwise (CCW) circulating waves internal to the cylinder's circumference. By symmetry, these two counter-propagating waves are degenerate, except for a phase factor. In the ray model, these CW and CCW waves are incident at angles greater than the total-internal-reflection angle ( c = sin - 1 (1/n)). Associated with the evanescent wave is a surface wave that is tangent to the interface Leakage out of the cavity is through the surface-wave component because the curved interface converts the surface wave into a propagating wave, which we detect as the far-field intensity. The order of the WGM radial component determines the penetration length of the evanescent field outside the cylinder. The nth order radial component has n peaks (when angle is averaged) as the distance along the radius increases from 0 to a. For the 1 st order WGM, this mode will have the shortest penetration length, the lowest amount of surface waves, and, hence, the highest Q-value. In the ray picture, the incident angle for the 1 st order is largest compared to higher orders for the radial function. WGM peaks in the fluorescence and Raman spectra are referred to as output resonances.
Isothermal Mashing of Barley Malt: New Insights into Wort Composition and Enzyme Temperature Ranges (2022)

Abstract The basic step in beer production is mashing, during which insoluble starch chains, and to a lesser extent cell walls and proteins are broken down by enzymatic hydrolysis. Since the beginning of the modern brewing process there have been empirical studies into the optimum effective temperatures of the corresponding enzymes, and mashing has been carried out accordingly. The resulting resting temperatures of proteolysis, cytolysis and amylolysis with the maltose and saccharification rest, are now rarely changed, only being adapted to the properties of the raw materials used to a limited extent. New varieties of barley and other raw materials used in breweries, as well as modern processes in malting plants, ensure better enzyme potential and optimized malt gelatinization temperatures. The aim of this paper is to determine enzyme activity in barley malt during mashing. For this purpose, isothermal mashing was used, i.e., a mashing process with a constant resting temperature over the entire mashing period. The obtained worts were analyzed for the attributes of extract, final attenuation, β-glucan, total nitrogen, free amino nitrogen, viscosity, and pH as well as sugar composition and individual amino acids. The change in these attributes indicates the enzyme activity of the malt.
Update on the use of defibrotide (2012)

Defibrotide may be effective in the prophylaxis and the treatment of veno-occlusive disease. Recent experimental results suggest that defibrotide may belong to the new generation of anti-cancer drugs that can prevent tumor angiogenesis. In multiple myeloma, defibrotide may overcome the prothrombotic effect of thalidomide on endothelial cells. Further preclinical and clinical investigations are needed to assess the precise role of defibrotide in the treatment of patients with multiple myeloma.
Improved Thin Layer Chromatographic Method for the Isolation and Estimation of Sterigmatocystin in Grains (1977)

Abstract A modified thin layer chromatographic (TLC) method has been developed in conjunction with the method of Stack and Rodricks which effectively separates sterigmatocystin from interfering materials and eliminates the time-consuming column chromatographic cleanup step. Initial extraction with acetonitrile-water (9+1) containing KCl is followed by partition of the extract first against hexane and then against CHCl3. The CHCl3 extract is evaporated and the residue is dissolved in benzene and applied directly to pre-coated high resolution TLC plates, which are developed in benzene-acetic acid (90+10). Visualization of the sterigmatocystin on TLC plates is enhanced by an AlCl3 spray reagent, and concentrations of sterigmatocystin as low as 50 μg/kg can be estimated by comparing fluorescence intensity against a pure sterigmatocystin standard. The method has been applied to barley, white and yellow corn, oats, and wheat. Recoveries of added toxin in the range of 50—400 μg/kg ranged from 86.3% for yellow corn and oats to &amp;gt;96% for barley, wheat, and white corn.
Amor i navegació. Transsumptes de la poesia en els Amores d'Ovidi (1995)

Some pieces from the Ovid's Amores contain programmatic allusions concerning the author's poetical principles. The poetry itself is presented under two different images: as the loved woman -an image from neoteric inheritance- and as the navigator exposed to risks at sea. The use of this last allegory -suggests the paper- is indebted to Aratus from Soli, whose famous poem Phaenornena was very well known by Ovid.
Hereditary Alpha1-Antitrypsin Deficiency (1968)

Serum specimens from 93 members of six families and three additional persons in the United States with serum alpha1-antitrypsin deficiency and familial emphysema were studied to define the genetics of this protein deficiency. The total antitryptic activity of serum, used as a measure of functional integrity of alpha1-antitrypsin, correlated highly with a radial gel immunoassay of its protein concentration. Studies of these two quantitative technics suggest an autosomal recessive mode of inheritance for the deficiency of alpha1-antitrypsin. Agarose electrophoresis was used to confirm these results and to recognize genetic variants. The patient material was highly selected from the clinical practice of pulmonary diseases, and a high correlation was found between homozygous deficiency of the alpha1-antitrypsin and chronic obstructive pulmonary disease. No remarkable rate of occurrence of pulmonary disease was noted among either genetic heterozygotes or family members with normal alpha1-antitrypsin function and concentration.
Interactions of Organosilanes with Fibrinogen and Their Influence on Muscle Cell Proliferation in 3D Fibrin Hydrogels (2019)

Silanization of biomacromolecules has emerged as a fruitful approach to prepare hybrid biohydrogels. However, very little is known about interactions between organosilanes and biopolymers in solution. Here we focused on fibrin, a protein of interest in the biomedical field, whose self-assembly process and resulting gel structure are highly sensitive to experimental conditions. Three main silanes were selected to decipher the relative influence of the silanol groups and organic functions. Whereas no protein denaturation was observed, silanes bearing hydrophobic groups had a surfactant-like behavior and could improve the dispersion of fibrinogen molecules, impacting gel formation kinetics and rheological properties. 3D cultures of myoblasts evidenced that organosilanes could promote or impede cell proliferation, suggesting interactions of silanols with fibrin. These results demonstrate that the two sides of the coin of organosilane reactivity are relevant at different stages of fibrin gel formation and must be considered for future development of hybrid biomaterials.
The Performance Test and the Feasibility Study for a Dual-Source Heat Pump System Using the Air and Ground Heat Source (2014)

Recently, the use of renewable energy has been increased due to growing concern on the energy-saving at buildings and the reduction of <TEX>$CO_2$</TEX> emission. In the field of architecture, to reduce the energy consumption of heating, cooling and hot water supply, heat pump systems with renewable energy has been developed and used in various applications. However, there have been many of researches on the large-scale commercial heat pump systems, but the research and the field application of a compact heat pump system is rare. Therefore, in order to develop the compact heat pump for the small-scale residential building, this study conducted the performance test and feasibility study for a hybrid heat pump using the heat source of air, solar and ground. In the results of experiments through a trial product, the average COP of cooling mode with ground heat source was 4.75, and it of heating mode was 4.03. Furthermore, the average COP of cooling mode with air heat source was 2.60, and it of heating mode was 2.92. Finally, payback period of the system was calculated as 9.2 years.
Protective Efficacy of an Orf Virus-Vector Encoding the Hemagglutinin and the Nucleoprotein of Influenza A Virus in Swine (2021)

Swine influenza is a highly contagious respiratory disease of pigs caused by influenza A viruses (IAV-S). IAV-S causes significant economic losses to the swine industry and poses challenges to public health given its zoonotic potential. Thus effective IAV-S vaccines are needed and highly desirable and would benefit both animal and human health. Here, we developed two recombinant orf viruses, expressing the hemagglutinin (HA) gene (OV-HA) or the HA and the nucleoprotein (NP) genes of IAV-S (OV-HA-NP). The immunogenicity and protective efficacy of these two recombinant viruses were evaluated in pigs. Both OV-HA and OV-HA-NP recombinants elicited robust virus neutralizing antibody response in pigs, with higher levels of neutralizing antibodies (NA) being detected in OV-HA-NP-immunized animals pre-challenge infection. Although both recombinant viruses elicited IAV-S-specific T-cell responses, the frequency of IAV-S-specific proliferating CD8+ T cells upon re-stimulation was higher in OV-HA-NP-immunized animals than in the OV-HA group. Importantly, IgG1/IgG2 isotype ELISAs revealed that immunization with OV-HA induced Th2-biased immune responses, whereas immunization with OV-HA-NP virus resulted in a Th1-biased immune response. While pigs immunized with either OV-HA or OV-HA-NP were protected when compared to non-immunized controls, immunization with OV-HA-NP resulted in incremental protection against challenge infection as evidenced by a reduced secondary antibody response (NA and HI antibodies) following IAV-S challenge and reduced virus shedding in nasal secretions (lower viral RNA loads and frequency of animals shedding viral RNA and infectious virus), when compared to animals in the OV-HA group. Interestingly, broader cross neutralization activity was also observed in serum of OV-HA-NP-immunized animals against a panel of contemporary IAV-S isolates representing the major genetic clades circulating in swine. This study demonstrates the potential of ORFV-based vector for control of swine influenza virus in swine.
Fucoidan Hydrogels Significantly Alleviate Oxidative Stress and Enhance the Endocrine Function of Encapsulated Beta Cells (Adv. Funct. Mater. 35/2021) (2021)

Fucoidan Hydrogels In article number 2011205, Tiago H. Silva, Aart A. van Apeldoorn, and co-workers explore the potential of fucoidan, a marine sulfated polysaccharide, for pancreatic islet encapsulation. Fucoidan has high fucose contents with sulfate groups, demonstrating potent antioxidant properties and significantly alleviating oxidative stress and enhancing the viability and function of encapsulated beta cells. A fucoidan-based hydrogel is thus assessed as biomaterial for bioengineered immunoprotective beta cell replacement systems.
Expecting the Unexpected: The Influence of Elastic Parameter Variance on Bayesian Facies Inversion (2019)

Summary Bayesian inversion is used for the prediction of lithology and fluids from AVO seismic data. We assume a multidimensional Gaussian rock physics prior model for the elastic parameters. In this study, we look at the role of the elastic parameters variance in the prior model and how it can impact facies predictions. When the facies classes contained in the prior model have different variance, this difference influences the inversion beyond just adding uncertainty to the seismic reflections. We examine the balance between the influence of this variance and the match with expected seismic data. Our results show that although the variance influence may lead to unexpected results in synthetic scenarios, it also helps to predict the facies configuration when the seismic data follows the prior distribution and forward model.
Viscous Fingering and the Shape of an Electronic Droplet in the Quantum Hall Regime (2002)

We show that the semiclassical dynamics of an electronic droplet, confined in a plane in a quantizing inhomogeneous magnetic field in the regime where the electrostatic interaction is negligible, is similar to viscous (Saffman-Taylor) fingering on the interface between two fluids with different viscosities confined in a Hele-Shaw cell. Both phenomena are described by the same equations with scales differing by a factor of up to 10(-9). We also report the quasiclassical wave function of the droplet in an inhomogeneous magnetic field.
Refractive indices of water and ice in the 065- to 25-μm spectral range (1993)

New accurate values of the imaginary part, k, of the refractive index of water at T = 22 °C, supercooled water at T = -8 °C and polycrystalline ice at T = -25 °C are reported. The k spectrum for water in the spectral region 0.65-2.5 µm is found to be in excellent agreement with those of previous studies. The k values for polycrystalline ice in the 1.44-2.50-µm region eliminate the large uncertainties existing among previously published conflicting sets of data. The imaginary part of refractive index of supercooled water shows a systematic shift of absorption peaks toward the longer wavelengths compared with that of water at warmer temperatures.
Selection of abnormal neural oscillation patterns associated with sentence-level language disorder in Schizophrenia (2012)

Language disorder is one of the core symptoms in schizophrenia. We propose a new framework based on machine intelligence techniques to investigate abnormal neural oscillations related to this impairment. Schizophrenia patients and healthy control subjects were instructed to discriminate semantically and syntactically correct sentences from syntactically correct but semantically incorrect sentences presented visually, and 248-channel MEG signals were recorded with a whole head machine during the task performance. Oscillation patterns were extracted from the MEG recordings in 8 frequency sub-bands throughout sentence processing, which form a large feature set. A two-step feature selection algorithm combining F-score filtering and Support Vector Machine recursive feature elimination (SVM-RFE) was designed to pick out a small subset of features which could discriminate patients and controls with high accuracy. We achieved a 90.48% prediction accuracy based on the selected top features, following the leave-one-out cross validation procedure. These top features provide interpretable spectral, spatial, and temporal information about the electrophysiological basis of sentence processing abnormality in schizophrenia which may help understand the underlying mechanism of this disease.
A novel nonlinear robust control strategy of hydro turbine governor: simulation and experiment (2004)

A new nonlinear robust control strategy for a hydro turbine governor is proposed based on differential geometry theory and the nonlinear robust control principle. The proposed control strategy improves system robustness to exogenous disturbances on the system in the sense of L/sub 2/-gain. Furthermore, a real controller that employs the suggested control strategy has been built for a dynamic experiment. The experimental results on a simple power system show clearly that the suggested control strategy can enhance transient stability of power systems more effectively than traditional PID controllers.
Observation of the 6/16/-5/15/ transitions of acetaldehyde in Sagittarius B2 (1976)

The 6(16)-5(15) transitions of acetaldehyde have been observed in the Sgr B2 molecular cloud. The large line width suggests that both the A and E symmetry states are present with essentially equal intensity. This is the first observation of acetaldehyde at millimeter wavelengths, and the intensity indicates that many other millimeter-wave lines of acetaldehyde should be detectable.
Determination of Trace Amounts of Sulfur in Iron and Steel by Combustion-Coulometry. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Trace Amounts of Sulfur in Iron and Steel by Combustion-Coulometry.W. R. Bandi, E. G. Buyok, and W. A. StraubCite this: Anal. Chem. 1966, 38, 11, 1485–1489Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ac60243a008https://doi.org/10.1021/ac60243a008research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 1182: The NEDD8 inhibitor pevonedistat blocks the repair of topoisomerase I (TOP1)-induced replication damage and synergizes with TOP1 inhibitors (2021)

Abstract Genomic DNA is constantly challenged by various genotoxic substances, resulting in an array of DNA lesions including DNA-protein crosslinks (DPCs), one of the most detrimental forms of DNA damage. Topoisomerase I (TOP1) is the molecular target of anti-cancer agents camptothecin derivatives and indenoisoquinolines, which act by trapping TOP1 on genomic DNA. The resulting TOP1-DPCs interfere with DNA replication and transcription and trigger cell death if left unrepaired. In this work, we found that the ubiquitin-like protein NEDD8 plays a pivotal role in the repair of TOP1-DPCs by activating the cullin 4 (CUL4)-RING ubiquitin ligases (CRL4) for K48-linked polyubiquitylation of TOP1-DPCs and their subsequent proteasomal degradation. We identified DCAF13, an understudied family member of DDB1- and CUL4-asscoiated factors, as the receptor of TOP1-DPCs for CRL4. DCAF13 colocalizes with TOP1-DPCs at nascent replication forks and binds the TOP1 core domain with its WD40 domains, linking TOP1 to DDB1-CRL4 for ubiquitylation upon TOP1-induced replication damage. Prompted by these findings, we hypothesized that targeting this NEDD8-activated repair pathway can be developed as a strategy to overcome resistance to TOP1 inhibitors. To test this hypothesis, we performed pharmacological analyses using CellMiner (http://discover.nci.nih.gov/cellminercdb) and found that the activities of TOP1 inhibitors and pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor in clinical trial, are highly correlated across cancer cell lines and with the expression of SLFN11. We also assessed the sensitivity of cultured cancer cells to combination of clinical TOP1 inhibitors and pevonedistat. The combination exhibited synergy in multiple cell lines particularly in human colon cancer cells HCT116 independently of SLFN11. We next investigated the efficacy of combination with TOP1 inhibitor topotecan and pevonedistat in HCT116 xenografts and observed supra-additive effect on tumor growth inhibition. Taken together, our work not only identifies a novel pathway for the repair of TOP1-DPCs but also provides translational evidence to support pevonedistat in combination with TOP1 inhibitors as a rationale therapeutic combination for cancer treatments. Citation Format: Yilun Sun, Andrea Baechler, Valentina Factor, Kanako Okamoto, Yves Pommier. The NEDD8 inhibitor pevonedistat blocks the repair of topoisomerase I (TOP1)-induced replication damage and synergizes with TOP1 inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1182.
Transcranial Magnetic Stimulation in Child Neurology: Current and Future Directions (2007)

Transcranial magnetic stimulation (TMS) is a method for focal brain stimulation based on the principle of electromagnetic induction, where small intracranial electric currents are generated by a powerful, rapidly changing extracranial magnetic field. Over the past 2 decades TMS has shown promise in the diagnosis, monitoring, and treatment of neurological and psychiatric disease in adults, but has been used on a more limited basis in children. We reviewed the literature to identify potential diagnostic and therapeutic applications of TMS in child neurology and also its safety in pediatrics. Although TMS has not been associated with any serious side effects in children and appears to be well tolerated, general safety guidelines should be established. The potential for applications of TMS in child neurology and psychiatry is significant. Given its excellent safety profile and possible therapeutic effect, this technique should develop as an important tool in pediatric neurology over the next decade.
I Drive My Car and My States Drive Me (2018)

Drivers' emotional and physical states have a big impact on their driving performance. New technological sensing methods are currently investigated and will soon allow to automatically detect the driver's state. Yet, how to communicate the detected state to the driver is less well understood. In an iterative design process, we developed two concepts to increase the driver's awareness of this issue:
Location and the Web (2008)

The World Wide Web has become the world's largest networked information resource, but references to geographical locations remain unstructured and typically implicit in nature. This lack of explicit spatial knowledge within the Web makes it difficult to service user needs for location-specific information. At present, spatial knowledge is hidden in many small information fragments such as addresses on Web pages, annotated photos with GPS coordinates, geographic mapping applications, and geotags in user-generated content. Several emerging formats that primarily or secondarily include location metadata, like GeoRSS, KML, and microformats, aim to improve this state of affairs. However, the question remains how to extract, index, mine, find, view, mashup, and exploit Web content using its location semantics. This workshop brings together researchers from academia and industry labs to discuss and present the latest results and trends in all facets of the relationships between location concepts and Web information.