gebhart/patrepeval huggingface dataset:
Abstract 5552: Macrophages increase brain metastasis in a chick embryo model (2012)

Abstract Macrophages are known to promote tumor growth by various mechanisms. In the present study, we determined if macrophages could promote metastasis in the chick embryo models. The chorioallentoic membrane (CAM) of six chicken embryos was inoculated with 106 PC-3 human prostate cancer cells stably expressing GFP. Twelve hours later, 106 macrophages isolated from the peritoneal washings of three nude mice were added to the CAMs of three embryos. Embryo brains were removed on day 8 post-inoculation, and processed for cryosectioning. Imaging was performed using the IV-100 scanning laser microscope (Olympus Corp, Tokyo, Japan). Images were processed using Image J software in order to calculate the number, size, and total area of brain metastases in the control and macrophage groups. The macrophage group resulted in an average of 43.3 brain metastases compared to 5.5 in the control group (p=0.000001). There was also a significantly greater total metastatic area in the macrophage group of 504.8 mm2 compared to 100.5 mm2 in the control group (p= 0.000001). However, the control group showed a significantly larger size of individual metastases of 28.9 mm2 compared to 19.3 mm2 in the macrophage group (p= 0.0007). Macrophages, therefore, promote brain metastasis in the chick embryo model of human prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5552. doi:1538-7445.AM2012-5552
The ‘de Winter’ electrocardiogram pattern as a ST-elevation myocardial infarction equivalent: a case report (2019)

The 'de Winter' ECG pattern, as other 'STEMI equivalent', must be recognized promptly and treated as soon as possible with emergent reperfusion by percutaneous coronary intervention.
Structure–Property Relationships for a Series of Poly(ester amide)s Containing Amino Acids (2013)

Poly(ester amide)s (PEAs) composed of variable diols, dicarboxylic acids, and α-amino acids were synthesized and characterized to elucidate structure–property relationships. The PEAs were synthesized using both solution and interfacial approaches to obtain varying molecular weights (MWs) and polydispersities. Studies using differential scanning calorimetry and powder X-ray diffraction revealed a range of amorphous and semicrystalline behavior that was dependent on structure. The viscosities of the PEAs as a function of temperature were studied by rheology, and phase transitions were confirmed for some polymers. Mechanical properties were also investigated, and it was found that the PEAs could be tuned to exhibit elastomeric or brittle behavior by varying both the length of the diol and the amino acid moiety. This information provides new insights into the effects of PEA structure, MW, and MW distribution on PEA properties and will aid in the design and selection of PEAs with optimal properties for targeted applications.
Development and validation of the Arizona Cognitive Test Battery for Down syndrome (2010)

Neurocognitive assessment in individuals with intellectual disabilities requires a well-validated test battery. To meet this need, the Arizona Cognitive Test Battery (ACTB) has been developed specifically to assess the cognitive phenotype in Down syndrome (DS). The ACTB includes neuropsychological assessments chosen to 1) assess a range of skills, 2) be non-verbal so as to not confound the neuropsychological assessment with language demands, 3) have distributional properties appropriate for research studies to identify genetic modifiers of variation, 4) show sensitivity to within and between sample differences, 5) have specific correlates with brain function, and 6) be applicable to a wide age range and across contexts. The ACTB includes tests of general cognitive ability and prefrontal, hippocampal and cerebellar function. These tasks were drawn from the Cambridge Neuropsychological Testing Automated Battery (CANTAB) and other established paradigms. Alongside the cognitive testing battery we administered benchmark and parent-report assessments of cognition and behavior. Individuals with DS (n=74, ages 7-38 years) and mental age (MA) matched controls (n=50, ages 3-8 years) were tested across 3 sites. A subsample of these groups were used for between-group comparisons, including 55 individuals with DS and 36 mental age matched controls. The ACTB allows for low floor performance levels and participant loss. Floor effects were greater in younger children. Individuals with DS were impaired on a number ACTB tests in comparison to a MA-matched sample, with some areas of spared ability, particularly on tests requiring extensive motor coordination. Battery measures correlated with parent report of behavior and development. The ACTB provided consistent results across contexts, including home vs. lab visits, cross-site, and among individuals with a wide range of socio-economic backgrounds and differences in ethnicity. The ACTB will be useful in a range of outcome studies, including clinical trials and the identification of important genetic components of cognitive disability.
Synthesis of Poly(phenylene polysulfide) Networks from Elemental Sulfur and p-Diiodobenzene for Stretchable, Healable, and Reprocessable Infrared Optical Applications (2019)

The synthesis and characterization of poly(phenylene polysulfide) networks (PSNs) with controlled average sulfur ranks, from elemental sulfur (ES) and <i>p</i>-diiodobenzene (DIB), are investigated. The PSN films, prepared via simple hot pressing, are found to possess large extensibility up to around 300% and complete recovery of shape and mechanical properties after deformation, which are attributed to the loosely cross-linked network structures mainly consisting of linear poly(phenylene polysulfide) chains. The covalent polysulfide linkages in the PSNs also exhibit dynamic behaviors under ultraviolet (UV) or thermal treatment, thus, enabling self-healing and reprocessing of the films when scratched and broken, respectively. Combined with the unique mechanical properties of the PSNs, their high refractive index and excellent infrared (IR) transparency contribute to the preparation of stretchable, healable, and reprocessable IR transmitting materials for potential deformable and stretchable optical applications.
Multigenerational effects of heat manipulation during embryogenesis on body temperature and growth in broiler chickens (2018)

et la diffusion de documents scientifiques de niveau recherche, publis ou non, manant des tablissements d'enseignement et de recherche franais ou trangers, des laboratoires publics ou privs.
Application of the COM-B model to the correlates of children’s outdoor playing and the potential role of digital interventions: a systematic literature review (2022)

Children’s reduced engagement in outdoor playing in recent years has contributed to increasing academic and practice interests in understanding this behavior, as well as investigating the effectiveness of combined social, physical and digital interventions on stimulating children’s outdoor playing. This paper provides a systematic review of recent empirical evidence on the correlates of the outdoor playing behavior of children, ages 4–12. In addition, the potential roles of digital interventions in stimulating children’s outdoor playing are explored. The COM-B behavior change model is used to establish relevant correlates and functions of digital interventions. COM-B model defines behavior as the result of an interaction between three components: capability, opportunity and motivation. This model provides a basis for designing effective behavior change interventions. This paper’s contribution is twofold: it presents the case for adding ‘digital environment’ as a new component of the COM-B model, and it further develops a conceptual framework of different functions of digital interventions aiming at stimulating children’s outdoor playing behavior. The findings contribute to the theory-based behavior change interventions stimulating children’s outdoor playing.
NCL Method ITA-8.2 (2020)

Analysis of nanoparticle chemoattractant properties using label-free, real-time chemotaxis assay
Decoupled state estimation for humanoids using full-body dynamics (2014)

We propose a framework to use full-body dynamics for humanoid state estimation. The main idea is to decouple the full body state vector into several independent state vectors. Some decoupled state vectors can be estimated very efficiently with a steady state Kalman Filter. In a steady state Kalman Filter, state covariance is computed only once during initialization. Furthermore, decoupling speeds up numerical linearization of the dynamic model. We demonstrate that these state estimators are capable of handling walking on flat ground and on rough terrain.
Differential Perceptions of Health Care Quality in a Prepaid Group Practice (1970)

This study explores the differences in the relative importance that physicians, nurses, and different categories of patients place on certain aspects of care. The hospital provider for a prepaid group practice plan was used as a site, Differences were found between the importance placed on different attributes for seriously ill hospital patients and routine walk-in patients. All groups tended to perceive greater discrepancy between their own personal preferences and the priorities attributed to the hospital in the care provided routine walk-in patients as opposed to seriously ill hospital patients. Physicians tended to be most homogeneous and the patients tended to be least homogeneous in their preferences. Physicians tended to place more emphasis on the technical aspects while nurses placed more emphasis on the more personal aspects of care. Implications of these findings for the organizational evaluation of care are suggested.
Electron Linear Accelerator for the Pion Therapy (1981)

The electron linear accelerator has been designed for the pion therapy. The accelerating structures are of Disk and Washer (DAW) type and cooled by the help of heat pipes. The energy and beam current of the accelerator, are 500 MeV and 400 μA, respectively, with a conventional RF system. The length of the linac is about 50 m, which is shorter than those hitherto designed for a similar purpose. Production of the pions and inevitable background radiations, mainly, neutrons and electrons, at the target are optimized. A new cooling technique of the target is suggested. Collection of the pions emitted over about 1 str. is performed by using the superconducting coils of the SMPG and axisymmetric types. About 35 rad. 1/min. is expected at the position of a patient.
3H-Penciclovir (3H-PCV) Uptake Assay (2013)

Thymidine Kinase from human Herpes simplex virus type 1 (HSV1-TK) in combination with specific substrate prodrug nucleotide analogue ganciclovir (GCV) has been widely used as suicidal therapeutic gene for cancer gene therapy. <i>HSV1</i>, and its mutant (<i>HSV1-sr39TK</i>) with improved substrate specificity, were used as reporter genes for PET-imaging of various biological functions in small animals, by combining with radiolabeled substrates such as <sup>18</sup>F-FHBG and <sup>124</sup>I-FIAU. <sup>3</sup>H-Penciclovir (PCV) uptake assay is a method of choice used to determine the expression level of HSV1-TK in mammalian cells and tissues. HSV1-TK phosphorylate PCV and result in the formation of penciclovir monophosphate, and its subsequent phopsphorylation by cellular TK lead to the formation of penciclovir triphosphate, which is trapped selectively in cells expressing HSV-TK. <sup>3</sup>H-Penciclovir enables the detection of penciclovir uptake of mammalian cells and tissues by radioactive procedures such as scintillation counting. Here we describe the protocol to carry out <sup>3</sup>H-Penciclovir uptakes in mammalian cells.
Fetal gender determination using real-time quantitative polymerase chain reaction analysis of maternal plasma. (2004)

Because of its high correct prediction rate, fetal gender determination with maternal plasma using real-time quantitative PCR can be used as a pre-test to avoid unnecessary chorionic villus sampling for pregnancies at risk of fetal sex-associated disorders.
Motor imagery of gait: a new way to detect mild cognitive impairment? (2014)

Our results provide the first evidence that motor imagery of gait may be used as a biomarker of MCI in older adults.
Synthesis of Multilayered Diamond Films in Microwave Plasma with Periodic Nitrogen Injections (2021)

The use of polycrystalline diamond in optics (transparent windows) and electronics (heat sinks) usually requires polishing of a synthesized wafer. However, mechanical polishing of diamond faces certain difficulties, since it is a material with a record high hardness. In this study, we propose a new approach to forming low-roughness diamond layers by periodic time-limited adding (injection) of nitrogen into the standard methane‒hydrogen (CH4–H2) gas mixture. Nitrogen stimulates secondary nucleation on the formed well-faceted micrometer diamond grains, which prevents their further growth. The transition from a continuous supply of N2 to short-term injections prevents the formation of continuous nanocrystalline diamond layers and makes it possible to grow high-quality microcrystalline diamond layers between the nitrogen injection periods.
Cooperative control for sharing applications based on distributed multiparty desktop conferencing system: MERMAID (2003)

A distributed multiparty desktop conferencing system, called MERMAID, was developed for supporting a wide range of group cooperative work. The authors discuss basic conditions for shared applications and present a sharing control scheme using MERMAID-served functions. The scheme is based on a replicated architecture, in which a copy of the application runs at every site or workstation. MERMAID provides communication functions for maintaining an identical state across all copies of an application in a replicated architecture. Two examples are included. One is an example of sharing an inherently single-user application, and the other is of sharing an application with access to external resources.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structure of the charge-transfer complex of (DBTTF)(BTDA-TCNQ) (1992)

Benzodithiol-2-ylidene)-l,3-benzo- dithiole-2,2'-(4,6,10,12-tetraaza-5,11-dithiatricyclo- (7.3.0.03 ,7) dodeca-3,6,9,12-tetraene-2,8-diylidene)bi s- propanedinitrile, (DBTTF)(BTDA-TCN Q), ClnHs- 84.C12N882, Mr = 624.8, orthorhombic, Pnmn, a= 12.940(3), b= 13.551 (3), c=7.440(2) A, V = 1304.6 (5)/~3, Z = 2, D m = 1.60, Dx = 1.59 g cm -3, MMo Ka) = 0.71073 A, lz = 4.96 cm-l, F(000) = 632, T = 293 K, R = 0.067 (wR = 0.062) for 1028 reflections. The components of the complex, DBTTF (donor) and BTDA-TCNQ (acceptor), form a mixed-stack column along the c axis. There are no intermolecular contacts shorter than the sum of the van der Waals radii within the molecular stack and between the stacks. Introduction. BTDA-TCNQ forms a two-dimen- sional sheet-like network through S...N~---C inter- actions in the crystalline state (Kabuto, Suzuki, Yamashita & Mukai, 1986). Thus the charge-transfer complexes of BTDA-TCNQ with donor molecules containing S or Se atoms are expected to form a high-dimensional structure, which might stabilize the metallic state and induce high electrical conductivity along two or three mutually perpendicular direc- tions. In fact, the (TTF)(BTDA-TCNQ) complex (Suzuki, Kabuto, Yamashita & Mukai, 1987) (TTF = tetrathiafulvalene) has a sheet-like network struc- ture, but it shows a very low conductivity because of its mixed-stack structure. Recently, we have synthe- sized the charge-transfer complexes of (tetraseleno- tetracene)(BTDA-TCNQ), and found that one of the crystal modifications has a segregated-stack struc- ture: this complex keeps a metallic state down to 1.5K without undergoing a Peierls transition (Ugawa, Iwasaki, Kawamoto, Yamashita, Yakushi
TOI-1634 b: An Ultra-short-period Keystone Planet Sitting inside the M-dwarf Radius Valley (2021)

Studies of close-in planets orbiting M dwarfs have suggested that the M dwarf radius valley may be well-explained by distinct formation timescales between enveloped terrestrials, and rocky planets that form at late times in a gas-depleted environment. This scenario is at odds with the picture that close-in rocky planets form with a primordial gaseous envelope that is subsequently stripped away by some thermally-driven mass loss process. These two physical scenarios make unique predictions of the rocky/enveloped transition's dependence on orbital separation such that studying the compositions of planets within the M dwarf radius valley may be able to establish the dominant physics. Here, we present the discovery of one such keystone planet: the ultra-short period planet TOI-1634 b ($P=0.989$ days, $F=121 F_{\oplus}$, $r_p = 1.790^{+0.080}_{-0.081} R_{\oplus}$) orbiting a nearby M2 dwarf ($K_s=8.7$, $R_s=0.45 R_{\odot}$, $M_s=0.50 M_{\odot}$) and whose size and orbital period sit within the M dwarf radius valley. We confirm the TESS-discovered planet candidate using extensive ground-based follow-up campaigns, including a set of 32 precise radial velocity measurements from HARPS-N. We measure a planetary mass of $4.91^{+0.68}_{-0.70} M_{\oplus}$, which makes TOI-1634 b inconsistent with an Earth-like composition at $5.9\sigma$ and thus requires either an extended gaseous envelope, a large volatile-rich layer, or a rocky portion that is not dominated by iron and silicates to explain its mass and radius. The discovery that the bulk composition of TOI-1634 b is inconsistent with that of the Earth favors the gas-depleted formation mechanism to explain the emergence of the radius valley around M dwarfs with $M_s\lesssim 0.5 M_{\odot}$.
VESYS5 RUTTING MODEL CALIBRATIONS WITH LOCAL ACCELERATED PAVEMENT TEST DATA AND ASSOCIATED IMPLEMENTATION (2002)

The Texas Department of Transportation (TxDOT) in cooperation with the Federal Highway Administration (FHWA) has established a Pooled Fund Study. The objective of this study is to integrate the accelerated pavement test technologies of Texas and other participating states with modeling capabilities developed by the FHWA in their Truck Pavement Interaction (TPI) program. This study will focus on the calibration and implementation of the latest version of the TPI software: VESYS5 to address truck size and weight policy issues related to the economic impact of heavy loads along the NAFTA corridor. This report summarizes the research accomplishments of the Texas Transportation Institute (TTI). First, a comprehensive framework of calibrating performance model using APT data is developed. Then, as the full case study, TxMLS data on US281 are used to calibrate the VESYS5 model. The reasonable rutting parameters (GNU and ALPHA) of asphalt mixtures are backcalculated and used to calibrate the laboratory-determined rutting parameters which are measured based on the test protocol developed at TTI. In addition, the effectiveness of VESYS test methodology is validated by US281-SPS1 and LA-ALF field data. The information of truck size and weight in the U.S., Mexico, and Canada is compiled based on the comprehensive literature review. Then this information is used as the input of the calibrated VESYS5 model to demonstrate the influence of different types of trucks in the U.S., Mexico, and Canada on pavement rutting damage.
Characteristics of the Berner Impactor for Sampling Inorganic Ions (1988)

The Berner cascade impactor was studied extensively to validate a method for measuring the size distributions of inorganic ionic chemicals in ambient air. Stage efficiencies were calibrated from 0.06- to 10-μm particle diameters; the monodisperse submicron test aerosol was solid ammonium fluorescein coated with oleic acid. Sampled alone, laboratory-generated liquid aerosol suffers blowoff from the last two stages, but this effect is absent with ambient aerosol. Stage cutoffs are sharp and wall losses small. A fluorocarbon grease compatible with acid and ion analysis was shown to prevent particle bounce effectively. Ammonium sulfate particles are sized properly at high relative humidity, ruling out possible growth by condensation during jet expansion. The volatilization loss of submicron ammonium nitrate particles is less than 10% under conditions that produce up to 95% loss from Teflon filters. On the basis of loading experiments, this result is ascribed mainly to the small surface-to-mass ratio of the deposits. A data inversion program was developed, based on a Smooth-Twomey algorithm by Markowski. An example of the size distribution of the principal inorganic ions in ambient air is presented.
Monte Carlo Study of Electronic Transport in Monolayer InSe (2019)

The absence of a band gap in graphene makes it of minor interest for field-effect transistors. Layered metal chalcogenides have shown great potential in device applications thanks to their wide bandgap and high carrier mobility. Interestingly, in the ever-growing library of two-dimensional (2D) materials, monolayer InSe appears as one of the new promising candidates, although still in the initial stage of theoretical studies. Here, we present a theoretical study of this material using density functional theory (DFT) to determine the electronic band structure as well as the phonon spectrum and electron-phonon matrix elements. The electron-phonon scattering rates are obtained using Fermi's Golden Rule and are used in a full-band Monte Carlo computer program to solve the Boltzmann transport equation (BTE) to evaluate the intrinsic low-field mobility and velocity-field characteristic. The electron-phonon matrix elements, accounting for both long- and short-range interactions, are considered to study the contributions of different scattering mechanisms. Since monolayer InSe is a polar piezoelectric material, scattering with optical phonons is dominated by the long-range interaction with longitudinal optical (LO) phonons while scattering with acoustic phonons is dominated by piezoelectric scattering with the longitudinal (LA) branch at room temperature (T = 300 K) due to a lack of a center of inversion symmetry in monolayer InSe. The low-field electron mobility, calculated considering all electron-phonon interactions, is found to be 110 cm<sup>2</sup>V<sup>-1</sup>s<sup>-1</sup>, whereas values of 188 cm<sup>2</sup>V<sup>-1</sup>s<sup>-1</sup> and 365 cm<sup>2</sup>V<sup>-1</sup>s<sup>-1</sup> are obtained considering the long-range and short-range interactions separately. Therefore, the calculated electron mobility of monolayer InSe seems to be competitive with other previously studied 2D materials and the piezoelectric properties of monolayer InSe make it a suitable material for a wide range of applications in next generation nanoelectronics.
Cover Picture: Bisamidate Prodrugs of 2‐Substituted 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis (ChemMedChem 8/2015) (2015)

The front cover picture shows the molecular mechanism of inhibition of adenylate cyclase (AC) toxin (ACT) from Bordetella pertussis, the pathogen that causes whooping cough. Upon activation by endogenous calmodulin (CaM), ACT converts ATP into cAMP causing intracellular cAMP concentrations to increase to supraphysiologic levels in an unregulated manner and disruption of the host cell functions. Novel C-2-modified analogues of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA, adefovir) in the form of their bisamidate prodrugs were designed and found to be efficient ACT inhibitors. The compounds displayed favorable plasma stability, the ability to be effectively distributed to target tissues, as well as good selectivity for ACT over human AC isoforms AC1, AC2 and AC5. Thus, ACT inhibition with acyclic nucleoside phosphonates may represent a viable strategy to treat whooping cough. For further details, see the Full Paper by M. Šmídková, Z. Janeba, et al. on p. 1351 ff.