gebhart/patrepeval huggingface dataset:
Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration (2023)

Abstract We describe here a near infrared light‐responsive elastin‐like peptide (ELP)‐based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo‐irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1‐monoblock ELP conjugates. Methionine residues in this monoblock are photo‐oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π‐π stacking, inducing the re‐formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of “smart” nanomedicines with deeper penetration capacity for effective anticancer therapies.
THE INDUCTION OF APOPTOTIC CELL DEATH BY THE HPV 16 E2 PROTEIN (1999)

Conference Abstract| June 01 1999 THE INDUCTION OF APOPTOTIC CELL DEATH BY THE HPV 16 E2 PROTEIN Kenneth Webster; Kenneth Webster 1Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK Search for other works by this author on: This Site PubMed Google Scholar Jo Parish; Jo Parish 1Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK Search for other works by this author on: This Site PubMed Google Scholar Kevin Gaston Kevin Gaston 1Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (3): A97. https://doi.org/10.1042/bst027a097b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Kenneth Webster, Jo Parish, Kevin Gaston; THE INDUCTION OF APOPTOTIC CELL DEATH BY THE HPV 16 E2 PROTEIN. Biochem Soc Trans 1 June 1999; 27 (3): A97. doi: https://doi.org/10.1042/bst027a097b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Podophyllin 10% and 25% in the treatment of ano-genital warts. A comparative double-blind study. (1981)

One hundred and forty male patients with ano-genital warts were randomly allocated to a double-blind study of 10% and 25% podophyllin in tincture of benzoin compound. One hundred and nine patients attended for a three-month period of surveillance. Only 24 (22%) patients were free of warts after having podophyllin treatment alone, 12 each after treatment with 10% and 25% podophyllin. There was no significant difference in the number of applications needed with each treatment. Neither hypersensitivity nor chemical ulceration occurred.
<title>Wideband antireflection coatings on germanium and filters for second optical window</title> (2003)

The investigation results of wideband (8-12 &mu;m) antireflection coatings on germanium substrate and spectral characteristics of interference wideband filter for spectral range of 8-12 &mu;m are presented. For design of filters and antireflection coatings the following layer materials were used: Ge, ZnS and Mira, and substrate materials such as: Ge for antireflection coatings and ZnSe for interference filters. Wideband filter for the range of 8-12 &mu;m requires application of additional two filters cutting off radiation from the range of 1-7 &mu;m. The cutting off filters are interference filters for which construction germanium, Mira, and ZnS were used. The constructions of basic and cutting off filters were designed considering technical possibilities of vacuum device BAK 550 of the Balzers firm.
A class of quasisymmetric mappings with substantial points (2000)

It is proved that Kq(h)=K0(h) for every h in some class of quasisymmetric mappings of the unit circle with substantial points, where Kq(h):=sup{M(h(Q))/M(Q); Qis a quadrilateral with the domain unit disk} and K0(h) is the extremal maximum dilatation of h.
Cervicovestibular Interactions in Coriolis-Like Effects (1992)

Abstract Human cervical mechanisms are very deeply connected to the vestibular system, and the contribution of the neck reflexes in postural control is mostly hidden. Consequently, neck reflexes are a subject of minor interest in neurology; clinical practice does not provide methodology to evaluate the contribution of the neck. However, because of the increasing number of patients with cervical ataxia due to acceleration trauma, research on the topic of cervicovestibular interactions is needed in order to find a methodology to sort out the contribution of the neck and the vestibular system in postural control. As a first approach to this research field, the authors did two pilot studies on horizon perception in healthy subjects.
Comparison of basis-vector selection methods for target and background subspaces as applied to subpixel target detection (2004)

This paper focuses on comparing three basis-vector selection techniques as applied to target detection in hyperspectral imagery. The basis-vector selection methods tested were the singular value decomposition (SVD), pixel purity index (PPI), and a newly developed approach called the maximum distance (MaxD) method. Target spaces were created using an illumination invariant technique, while the background space was generated from AVIRIS hyperspectral imagery. All three selection techniques were applied (in various combinations) to target as well as background spaces so as to generate dimensionally-reduced subspaces. Both target and background subspaces were described by linear subspace models (<i>i.e</i>., structured models). Generated basis vectors were then implemented in a generalized likelihood ratio (GLR) detector. False alarm rates (FAR) were tabulated along with a new summary metric called the average false alarm rate (AFAR). Some additional summary metrics are also introduced. Impact of the number of basis vectors in the target and background subspaces on detector performance was also investigated. For the given AVIRIS data set, the MaxD method as applied to the background subspace outperformed the other two methods tested (SVD and PPI).
Managing attack graph complexity through visual hierarchical aggregation (2004)

We describe a framework for managing network attack graph complexity through interactive visualization, which includes hierarchical aggregation of graph elements. Aggregation collapses non-overlapping subgraphs of the attack graph to single graph vertices, providing compression of attack graph complexity. Our aggregation is recursive (nested), according to a predefined aggregation hierarchy. This hierarchy establishes rules at each level of aggregation, with the rules being based on either common attribute values of attack graph elements or attack graph connectedness. The higher levels of the aggregation hierarchy correspond to higher levels of abstraction, providing progressively summarized visual overviews of the attack graph. We describe rich visual representations that capture relationships among our semantically-relevant attack graph abstractions, and our views support mixtures of elements at all levels of the aggregation hierarchy. While it would be possible to allow arbitrary nested aggregation of graph elements, it is better to constrain aggregation according to the semantics of the network attack problem, i.e., according to our aggregation hierarchy. The aggregation hierarchy also makes efficient automatic aggregation possible. We introduce the novel abstraction of protection domain as a level of the aggregation hierarchy, which corresponds to a fully-connected subgraph (clique) of the attack graph. We avoid expensive detection of attack graph cliques through knowledge of the network configuration, i.e. protection domains are predefined. While significant work has been done in automatically generating attack graphs, this is the first treatment of the management of attack graph complexity for interactive visualization. Overall, computation in our framework has worst-case quadratic complexity, but in practice complexity is greatly reduced because users generally interact with (often negligible) subsets of the attack graph. We apply our framework to a real network, using a software system we have developed for generating and visualizing network attack graphs.
How effective are Fatigue Risk Management Systems (FRMS)? A review (2021)

While FRMS are likely to be effective, in organisations where safety cultures are insufficiently mature and resources are less available, these systems may be challenging to implement successfully. We propose regulatory bodies consider a hybrid model of FRMS, where organisations could choose to align with tight hours of work (compliance) controls. Alternatively, where organisational flexibility is desired, a risk-based approach to fatigue management could be implemented.
Autoradiographic visualization of insulin-like growth factor-II receptors in rat brain (1986)

The documented presence of IGF-II in brain and CSF prompted us to investigate the distribution of receptors for IGF-II in rat brain slices. Human /sup 125/-I-IGF-II (10 pM) was incubated for 16 hrs at 4/sup 0/C with slide-mounted rat brain slices in the absence and presence of unlabeled human IGF-II (67 nM) or human insulin (86 nM). Slides were washed, dried, and exposed to X-ray film for 4-7 days. The results showed dense labeling in the granular layers of the olfactory bulbs, deep layers of the cerebral cortex, pineal gland, anterior pituitary, hippocampus (pyramidal cells CA/sub 1/-CA/sub 2/ and dentate gyrus), and the granule cell layers of the cerebellum. Unlabeled IGF-II eliminated most of the binding of these brain regions while insulin produced only a minimal reduction in the amount of /sup 125/I-IGF-II bound. These results indicate that a specific neural receptor for IGS-II is uniquely distributed in rat brain tissue and supports the notion that this peptide might play an important role in normal neuronal functioning.
Frequent lucid dreaming associated with increased functional connectivity between frontopolar cortex and temporoparietal association areas (2018)

Humans typically lack awareness that they are dreaming while dreaming. However, at times a remarkable exception occurs and reflective consciousness can be regained while dreaming, referred to as lucid dreaming. While most individuals experience lucid dreams rarely there is substantial variance in lucid dream frequency. The neurobiological basis of lucid dreaming is unknown, but evidence points to involvement of anterior prefrontal cortex (aPFC) and parietal cortex. This study evaluated the neuroanatomical/neurofunctional correlates of frequent lucid dreams and specifically whether functional connectivity of aPFC is associated with frequent lucid dreams. We analyzed structural and functional magnetic resonance imaging from an exceptional sample of fourteen individuals who reported ≥3 lucid dreams/week and a control group matched on age, gender and dream recall that reported ≤1 lucid dream/year. Compared to controls, the frequent lucid dream group showed significantly increased resting-state functional connectivity between left aPFC and bilateral angular gyrus, bilateral middle temporal gyrus and right inferior frontal gyrus, and higher node degree and strength in left aPFC. In contrast, no significant differences in brain structure were observed. Our results suggest that frequent lucid dreaming is associated with increased functional connectivity between aPFC and temporoparietal association areas, regions normally deactivated during sleep.
Auf der Spur der Evolution von einem als Gerüst in Enzymen dienenden (βα)8-Fass (2001)

Für den gezielten Umbau bereits vorhandener Proteingerüste zur Gewinnung neuer Enzyme mit gewünschten Eigenschaften stellt die molekulare Evolution ein leistungsfähiges Konzept dar. Zwei kürzlich erschienene Arbeiten demonstrieren das erfolgreiche Protein-Engineering des weit verbreiteten β/α-Fass-Enzymgerüstes (siehe Bild). In beiden Fällen wurden neue Katalysatoren mit veränderten Bindungs- und Katalyseeigenschaften erzeugt. Dies sind die ersten Beispiele einer erfolgreichen Transformation von Enzymaktivität mithilfe zielgerichteter Evolution.
Research issues in ubiquitous computing (1994)

some ongoing projects at Xerox PARC related to
Information Dynamics in the Networked World (2003)

We review three studies of information flow in social networks that help reveal their underlying social structure, how information spreads through them and why small world experiments work.
On Welding of High-Strength Steels Using Laser Beam Welding and Resistance Spot Weld Bonding with Emphasis on Seam Leak Tightness (2023)

The design of most electric vehicles provides for the positioning of the heavy energy storage units in the underbody of the cars. In addition to crash safety, the battery housing has to meet high requirements for gas tightness. In order to test the use of high-strength steels for this sub-assembly, this paper examines welded joints utilizing resistance spot weld bonding and laser remote welding, with special regard to the gas tightness of the welds. For this purpose, the pressure difference test and helium sniffer leak detection are presented and applied. The combination of both leak test methods has proven ideal in experimental investigations. For laser remote welding, gas-tight seams can be achieved with an inter-sheet gap of 0.1 mm, even if occasionally leaking samples cannot be prevented. Resistance spot welding suits gas-tight joining with both one- and two-component adhesives. Against the background of leak tightness, process fluctuations that lead to weld spatter and defects in the adhesive layer must be prevented with high priority.
An abstract journey (2015)

In the Abstract Thought sequence of Pixar's Inside Out the characters find themselves in a specific part of Riley's brain that processes abstract notions. They go through various stages of transformation towards abstraction as they try to find their way out.
Potential Treatment Adjustments to Infliximab Therapy in Ulcerative Colitis Patients: A Real World Retrospective Study (2011)

Purpose: Long term data on the persistence of infliximab (IFX) therapy are limited. Using a large health care claims database, we assessed the occurrence and economic implications of potential treatment adjustments (PTAs) to IFX in patients with ulcerative colitis (UC). Methods: The sample was selected from the i3 database (United Health Care®) and included patients with (1) ≥2 diagnoses of UC (ICD-9-CM: 556.x) between 5/1/2000 and 10/20/2010, (2) IFX maintenance therapy (≥4 infusions) on or after the first UC diagnosis date, (3) continuous health care coverage during both the 6 months preceding (baseline) and 6 months following (study period) initiation of IFX, and (4) IFX infusions that were all associated with a diagnosis of UC on or after the initiation date. The indicators of PTAs were defined as dosage escalation, switch to another biologic therapy, UC-related emergency department visit or hospitalization, or colectomy. Dosage escalation was defined as ≥2 infusions that cost ≥30% more than the second infusion or that occurred within 6 weeks of each other after the third infusion. The cumulative probability of PTAs over time was estimated using Kaplan-Meier methods. Health care costs during the study period were assessed for patients with and without PTAs within 1 year after therapy initiation using both descriptive and generalized linear models (GLMs). Descriptive differences were compared using Wilcoxon rank sum tests. Regression models with control for demographics, comorbidities, baseline treatments and health care resource utilization were used. Results: Of the 353 patients analyzed, 49.7% had PTAs within 1 year. Dosage escalation (40.3%) and UC-related hospitalizations (17.7%) were the most common PTAs. During the study period, descriptive (table) and GLM analyses (not shown) demonstrated that patients with PTAs had significantly greater costs than those without PTAs.Table: Table. Mean health care costs (2010 US$) during the 6 months after initiating IFX therapyConclusion: Approximately half of patients treated with IFX for UC experienced PTAs within 1 year. PTAs were associated with significant increases in total health care and UC-related costs. Disclosure: Dr. Tauseef Ali: Speaker: Abbott, UCB. Dr. Yifei Liu: Abbott. Drs. M Yang, P Mulani, and J Chao: Employee/Stock: Abbott. This research was supported by an industry grant from Abbott.
Climate‐related variation in mortality and recruitment determine regional forest‐type distributions (2013)

Abstract Aim The geographic distributions of different forest types are expected to shift in the future under altered climatic conditions. At present, the nature, magnitude and timing of these shifts are uncertain because we lack a quantitative understanding of how forest distributions emerge from climate‐ and competition‐related variation in underlying demographic processes. Forest dynamics result primarily from the manner in which the physical environment and competition for limiting resources affect tree growth, mortality and recruitment. We sought to uncover the relative importance of these processes in controlling the geographic limits of different forest types. Location E astern USA . Methods We parameterized a climate‐dependent forest dynamics model with extensive observations of tree growth, mortality and recruitment from forest inventory data. We then implemented the resulting demographic models in simulations of joint population dynamics for seven plant functional types ( PFTs ) across the region. By removing various climate effects in a series of simulation experiments, we assessed the importance of climate‐dependent demography and competition in limiting forest distributions. Results Distributions that emerged from simulated population dynamics approximated the current distributions for all seven PFT s well and captured several known patterns of succession. Temperature‐related increases in mortality determined the southern boundaries of three out of four boreal and northern temperate PFT s, whereas temperature‐related decreases in recruitment controlled the northern limit of all three southern temperate PFT s. Changes in growth rates and competitor performance had only minor effects on the distribution limits of most PFTs . Main conclusions Our results imply that dynamic global vegetation models, which are widely used to predict future vegetation distributions under climate change, should seek to more appropriately capture the observed climate sensitivity of mortality and recruitment. Understanding the mechanisms controlling forest distributions will enable better predictions of their future responses to climate change.
Modal interfaces (2009)

This paper presents a unification of interface automata and modal specifications, two radically dissimilar models for interface theories. Interface automata is a game-based model, which allows to make assumptions on the environment and propose an optimistic view for composition : two components can be composed if there is an environment where they can work together. Modal specification is a language theoretic account of a fragment of the modal mu-calculus logic that is more complete but which does not allow to distinguish between the environment and the component. Partial unifications of these two frameworks have been explored recently. A first attempt by Larsen et al. considers modal interfaces, an extension of modal specifications that deals with compatibility issues in the composition operator. However, this composition operator is incorrect. A second attempt by Raclet et al. gives a different perspective, and emphasises on conjunction and residuation of modal specifications, including when interfaces have dissimilar alphabets, but disregards interface compatibility. The present paper contributes a thorougher unification of the two theories by correcting the modal interface composition operator presented in the paper by Larsen et al., drawing a complete picture of the modal interface algebra, and pushing even further the comparison between interface automata, modal automata and modal interfaces.
The kinetics of formation and dissolution of uric acid crystals. (1978)

The kinetics of crystallization and dissolution of uric acid have been studied at temperatures from 15 to 45 C, using a highly reproducbile seeding technique. The rates of reaction have been followed by a precision conductometric method. The mineralization rate follows an equation second-order in relative supersaturation and the experimental evidence points to a surface controlled crystal growth. In contrast, the rapid dissolution of seed crystals into undersaturated uric acid solutions seems to be controlled by diffusion of electrolyte through the hydrodynamic boundary layer at the crystal surface. The activation energy for dissolution, 13.1 +/- 2.6 kJ/mole, is close to that expected for bulk diffusion. Values are reported for the solubility product and dissociation constant for uric acid from 15 to 45 C.
A Study on the Critical Success Factors of Electronic Commerce by Shopping Mall Awareness (2006)

The internet is not simply a new technology that businesses are adopting to reduce their costs of operations and increase revenues. This study reports a set of success factors for electronic commerce, specifically some important implications for managers of internet shopping mall area in Korea. In this study it is found that price and security are most critical to increase customer satisfaction. In addition, the result of this study shows that (1) price and security, (2) shopping mall interface and trust and (3) ease of use are very important to increase customer satisfaction. And the result of this study shows that shopping mall awareness are very important to increase customer satisfaction.
A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells (2021)

Abstract Potent cellular responses to viral infections are pivotal for long -lived protection. Evidence is growing that these responses are critical in SARS -CoV-2 immunity. Assessment of a SARS -CoV-2 spike ferritin nanoparticle (SpFN) immunogen paired with two distinct adjuvants, Alhydrogel® (AH) or Army Liposome Formulation containing QS-21 (ALFQ) demonstrated unique vaccine evoked immune signatures. SpFN+ALFQ enhanced recruitment of highly activated classical and non -classical antigen presenting cells (APCs) to the vaccine-draining lymph nodes of mice. The multifaceted APC response of SpFN+ALFQ vaccinated mice was associated with an increased frequency of polyfunctional spike -specific T cells with a bias towards T H 1 responses and more robust SARS-CoV-2 spike-specific recall response. In addition, SpFN+ALFQ induced K b spike (539-546) -specific memory CD8 + T cells with effective cytolytic function and distribution to the lungs. This epitope is also present in SARS-CoV, thus suggesting that generation of cross-reactive T cells may provide protection against other coronavirus strains. Our study reveals that a nanoparticle vaccine, combined with a potent adjuvant, generates effective SARS-CoV-2 specific innate and adaptive immune T cell responses that are key components to inducing long-lived immunity. One Sentence Summary SpFN vaccine generates multifactorial cellular immune responses.