gebhart/patrepeval huggingface dataset:
Electrostatic tuning of temperature coefficient of frequency of anisotropic disk-shaped resonators (2017)

This paper presents an electrostatic mechanism for tuning the temperature coefficient of frequency (TCf) of disk-shaped resonators fabricated in highly doped (100) single-crystalline silicon. Taking advantage of the degenerate nature of “wineglass” mode resonators such as rings and disks, we show that rotating the resonant mode shapes by electrostatically changing the boundary conditions can effectively tune the TCf. In this work, the proof-of-concept is demonstrated by matching the TCf of the drive and sense modes of a disk resonator gyroscope (DRG). By using electrostatic tuning, the two wineglass modes are each rotated by 22.5° from the natural 0° and 45° (with respect to <;110>) positions, resulting in a substantial reduction in the TCf mismatch between two modes. The capability to tune TCf of wineglass mode resonators has potential applications for not only continuous mode-matching operation of vibratory gyroscopes, but also temperature compensation of silicon-based MEMS oscillators.
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines (2010)

Immunochemotherapies have improved outcomes in indolent lymphoma. However, response durations progressively shorten following each treatment, and the majority of patients eventually die from the disease. Thus, new, less toxic, and more active treatments are needed. Protein kinase C (PKC), which has been repeatedly implicated in B-cell lymphoma progression, may be a new target for lymphoma cell growth inhibition. Enzastaurin, a PKC-beta inhibitor, has toxic effects on a variety of cancer cells. The purpose of the present study was to assess the antitumor activity of enzastaurin on B-cell lymphoma cell lines and to investigate the underlying antitumor mechanisms. Enzastaurin induced apoptosis and inhibited phosphorylation of PKC, RSK, AKT, and downstream proteins. Moreover, our results reveal a new mechanism for enzastaurin-induced apoptosis via BAD activation. Finally, enzastaurin synergizes in its effects with chlorambucil and fludarabine, respectively. Taken together, our results strongly support clinical evaluation of enzastaurin in patients with B-cell lymphoma.
Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases (2014)

Nonribosomal peptide synthetases (NRPSs) are multimodular proteins capable of producing important peptide natural products. Using an assembly line process, the amino acid substrate and peptide intermediates are passed between the active sites of different catalytic domains of the NRPS while bound covalently to a peptidyl carrier protein (PCP) domain. Examination of the linker sequences that join the NRPS adenylation and PCP domains identified several conserved proline residues that are not found in standalone adenylation domains. We examined the roles of these proline residues and neighboring conserved sequences through mutagenesis and biochemical analysis of the reaction catalyzed by the adenylation domain and the fully reconstituted NRPS pathway. In particular, we identified a conserved LPxP motif at the start of the adenylation-PCP linker. The LPxP motif interacts with a region on the adenylation domain to stabilize a critical catalytic lysine residue belonging to the A10 motif that immediately precedes the linker. Further, this interaction with the C-terminal subdomain of the adenylation domain may coordinate movement of the PCP with the conformational change of the adenylation domain. Through this work, we extend the conserved A10 motif of the adenylation domain and identify residues that enable proper adenylation domain function.
Unifying logic and probability (2015)

Open-universe probability models show merit in unifying efforts.
Spontaneous corneal melting during pregnancy: a case report (2009)

We advise caution in the ophthalmologic care of pregnant patients who have preexisting corneal thinning disorders or who have undergone multiple corneal surgeries, because physiologic changes during pregnancy might contribute to corneal changes leading to spontaneous melting especially in patients with compromised cornea.
Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques (2021)

The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogenicity, and decreased efficacy of medical countermeasures. Animal models can be used to assess phenotypical changes in the absence of confounding factors. Here, we compared variants of concern (VOC) B.1.1.7 and B.1.351 to a recent B.1 SARS-CoV-2 isolate containing the D614G spike substitution in the rhesus macaque model. B.1.1.7 behaved similarly to D614G with respect to clinical disease and replication in the respiratory tract. Inoculation with B.1.351 resulted in lower clinical scores, lower lung virus titers, and less severe lung lesions. In bronchoalveolar lavages, cytokines and chemokines were up-regulated on day 4 in animals inoculated with D614G and B.1.1.7 but not with B.1.351. In nasal samples, cytokines and chemokines were up-regulated only in the B.1.1.7-inoculated animals. Together, our study suggests that circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than increased pathogenicity.
Effects of an Electric Field of Sinusoidal Waves on the Amino Acid Biosynthesis by Azotobacter (1980)

Abstract Electric Field Electric fields of sinusoidal waves have been applied in cultures of Azotobacter vinelandii, with potentials between 0 V and 10 V, intensities from 0 mA to 16 mA and frequencies between 5 Hz and 200 KHz. The influence of the electric field of sinusoidal waves on the nitrogen fixation on the post­ culture medium composition has a maximum at 5 V, 8 mA and 20 Hz. The rate of synthesis of specific amino acids by Azotobacter depends on the frequency and potential of the electric field applied. The concentration of each amino acid present in the post-culture medium is increased according to the electric field employed and the amino acid biosynthesis in culture medium is activated during the first days of incubation.
Threshold Electron Impact Excitation of Atoms and Molecules: Detection of Triplet and Temporary Negative Ion States (1968)

A technique which utilizes SF6 as a scavenger of low-energy electrons is employed to study the “threshold” excitation spectra of He, N2, HCl, H2O, D2O and a number of aromatic molecules. For electrons within ∼0.03 eV of threshold, it is found that the probability of exciting the 23S state of helium is approximately 1.5 times larger than that for the 21S state. For HCl all of the optically allowed transitions are observed including a Rydberg series leading to the ionization potential. Temporary negative ion resonances are observed below the first electronic state for all of the aromatic molecules studied. For benzene, in addition to the optically allowed transitions, the first (3.9 eV) and second (4.7 eV) triplet states are detected, while for naphthalene a new intense level at 5.4 eV as well as the lower triplet states are observed.
La intervención de autoayuda por correo en el tratamiento de fumadores (2003)

In the treatment of the smokers has been increased in the last years the procedures for smoking cessation that result available for all smokers and that, at the same time, imply minimal interventions for the professionals. In this work is made a review of self-help interventions applied to the smoker´s treatment, which use written materials, fundamentally self-help manuals, and are distributed by mail. It is analyzed if variables such as extension, delivery way and/or tailoring of the material, contribute to increase the efficacy of such interventions. The results of the studies do not come out conclusive respect to the benefits from the application of the intervention program through self-help manuals or booklets. About the personalising materials, there is evidence that the most promising strategy seems to be the use of personalized feedback letters. Future studies should delimit the type of smokers that, more probably, get a benefit from a specific modality of self-help intervention.
Relative Compatibility of Parylene Conformal Coatings with No-Clean Flux Residues (1993)

Parylene coating tests of circuits produced with various no-clean soldering fluxes are conducted to determine the impact of no-clean circuit processing on the Parylene coatability of these boards. The properties and characteristics of Parylene conformal coating are described. Surface insulation resistance test procedures and results for no-clean flux/no-clean soldered and Parylene coated circuit samples are summarized. >
Lipoprotein lipase and hepatic lipase (2003)

HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied their relationship with Lp(A-I) and Lp(A-I,A-II). LPL was positively correlated with the apolipoprotein A-I (apoA-I), cholesterol, and phospholipid mass in total Lp(A-I), and with the apoA-I in large Lp(A-I) (r >or= 0.58, P >or= 0.001). HL was negatively correlated with all the above Lp(A-I) parameters plus Lp(A-I) triglyceride (r >or= -0.53, P <or= 0.003). No correlation was detected between LPL and Lp(A-I,A-II). However, HL was inversely correlated with total Lp(A-I,A-II) phospholipid, and with large Lp(A-I,A-II) (r >or= 0.50, P <or= 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0.009) was significantly correlated with PLTP activity. These observations indicate that LPL and HL play major roles in determining the level and composition of plasma Lp(A-I), particularly large Lp(A-I), but not with Lp(A-I,A-II) level. Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated.
Thoracic Extramedullary Hematopoiesis Associated with Hereditary Spherocytosis. (1992)

A 54-year-old man was diagnosed with hereditary spherocytosis. An X-ray of the chest disclosed bilateral round masses in the upper and lower posterior mediastinum. CT showed homogeneous round masses of soft tissue density in the posterior mediastinum. A needle biopsy of the mass showed hyperplastic erythroid bone marrow. Fatty metamorphosis of the masses was observed in CT 2 years after splenectomy but showed no change in size.
Digitally controlled voltage regulator using oscillator-based ADC with fast-transient-response and wide dropout range in 14nm CMOS (2017)

In this paper, we propose a digitally controlled voltage regulator with fast-transient-response using an oscillator based ADC implemented in 14nm CMOS technology. The transient response is critical to mitigate droop for large di/dt seen in cores and wide dropout range helps enable DVFS to improve power/performance ratio. In this work, we target 1-1.15V input voltage with output voltage range of 0.5-1.12V with minimum 30mV dropout, and load current range of >22x with 0.1A-2.2A at 50mV dropout with <;0.006mV/mA load regulation using 10-bit power-stage binary control and characterized using a slew-rate programmable synthetic resistive load on-die to mimic core with 18nF load capacitance implemented on-die using area over load.
Estudo da dispersão de argilas organofílicas em nanocompósitos de prolipropileno obtidos pelo método em solução com auxílio de ultrassom (2013)

Nanocompósitos de polipropileno PP/OMMT foram preparados com o uso de duas argilas modificadas organofilicamente (C-15A e I-44P) e de um compatibilizante (PP-g-MA) pelo método em solução utilizando-se um banho de ultrassom. O objetivo deste estudo foi compreender a morfologia dos nanocompósitos, ou seja, o grau de dispersão destas argilas na matriz de polipropileno, e consequentemente, correlacioná-la com as propriedades finais obtidas. A morfologia dos nanocompósitos foi avaliada por Difração de Raios X (DRX) e Microscopia Eletrônica de Transmissão (MET). As propriedades mecânico-dinâmicas e térmicas dos nanocompósitos foram avaliadas por Análise Mecânico-Dinâmica (DMA) e Calorimetria Diferencial de Varredura (DSC). Análises estatísticas das imagens de transmissão foram realizadas possibilitando a obtenção da razão de aspecto (comprimento/espessura) das partículas de argila.
Thoracoscopic Repair of Congenital Diaphragmatic Hernia in Neonates: Lessons Learned (2009)

Thoracoscopic repair of CDH is a safe, effective strategy in patients who have undergone prior stabilization. Stomach herniation is associated with, but does not categorically predict, conversion to open repair. ECMO use prior to repair should not be an absolute contraindication to thoracoscopic repair.
Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate (2013)

Nerve functions require phosphatidylinositol-4,5-bisphosphate (PIP2) that binds to ion channels, thereby controlling their gating. Channel properties are also attributed to serotonin transporters (SERTs); however, SERT regulation by PIP2 has not been reported. SERTs control neurotransmission by removing serotonin from the extracellular space. An increase in extracellular serotonin results from transporter-mediated efflux triggered by amphetamine-like psychostimulants. Herein, we altered the abundance of PIP2 by activating phospholipase-C (PLC), using a scavenging peptide, and inhibiting PIP2-synthesis. We tested the effects of the verified scarcity of PIP2 on amphetamine-triggered SERT functions in human cells. We observed an interaction between SERT and PIP2 in pull-down assays. On decreased PIP2 availability, amphetamine-evoked currents were markedly reduced compared with controls, as was amphetamine-induced efflux. Signaling downstream of PLC was excluded as a cause for these effects. A reduction of substrate efflux due to PLC activation was also found with recombinant noradrenaline transporters and in rat hippocampal slices. Transmitter uptake was not affected by PIP2 reduction. Moreover, SERT was revealed to have a positively charged binding site for PIP2. Mutation of the latter resulted in a loss of amphetamine-induced SERT-mediated efflux and currents, as well as a lack of PIP2-dependent effects. Substrate uptake and surface expression were comparable between mutant and WT SERTs. These findings demonstrate that PIP2 binding to monoamine transporters is a prerequisite for amphetamine actions without being a requirement for neurotransmitter uptake. These results open the way to target amphetamine-induced SERT-dependent actions independently of normal SERT function and thus to treat psychostimulant addiction.
Mechanical ventilation and the diseased lung (2000)

Copyright © by 2000 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
STEAM: a fast compact thermal model for two-phase cooling of integrated circuits (2013)

Two-phase liquid cooling of computer chips via microchannels etched directly on silicon dies is a potential long-term solution to enable continued integration of high-performance multiprocessors. Two-phase cooling refers to the heat removal via evaporation of a refrigerant flowing inside a heat sink. While possessing superior cooling properties, large-scale use of this technology in the industry is limited by the lack of thermal modeling tools that can accurately predict temperatures in a two-phase cooled IC. In this paper, we propose STEAM, a new compact thermal model for 2D/3D ICs with two-phase cooling via silicon microchannels. The accuracy of the STEAM model is validated against measurements from a real two-phase cooled IC test stack reported previously in literature. Temperatures were predicted with an average error as low as 10.2% for uniform heat fluxes and 6.9% for hotspots. Finally, the STEAM model is applied to a realistic 3D multiprocessor system-on-chip (3D MP-SoC) with two-phase cooling to simulate IC temperatures and the refrigerant pumping power, demonstrating the applicability of STEAM in the early-stage design of near-future high-performance computers with two-phase cooling.
Effect of thymopentin on the production of cytokines, heat shock proteins, and NF-κB signaling proteins (2008)

In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signal proteins NF-kappaB, phNF-kappaB, and IkappaB-alpha in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1alpha, IL-2, IL-6, IL-10, and IFN-gamma), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15 microg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-kappaB signaling pathway, which is most pronounced at the NF-kappaA phosphorylation stage.
The Optical Array: An Alternative to Scattering or Extinction for Airborne Particle Size Determination (1970)

An electro-optical technique is described for the measurement of the size distributions of cloud and precipitation particles. The technique utilizes a linear array of photodetectors as a size measuring grid in a typical shadowgraph-type imaging system. Several instruments have been designed and are described in various stages of testing and development. A thorough description of one such instrument and preliminary field data are given.
New perspectives and methods in link prediction (2010)

This paper examines important factors for link prediction in networks and provides a general, high-performance framework for the prediction task. Link prediction in sparse networks presents a significant challenge due to the inherent disproportion of links that can form to links that do form. Previous research has typically approached this as an unsupervised problem. While this is not the first work to explore supervised learning, many factors significant in influencing and guiding classification remain unexplored. In this paper, we consider these factors by first motivating the use of a supervised framework through a careful investigation of issues such as network observational period, generality of existing methods, variance reduction, topological causes and degrees of imbalance, and sampling approaches. We also present an effective flow-based predicting algorithm, offer formal bounds on imbalance in sparse network link prediction, and employ an evaluation method appropriate for the observed imbalance. Our careful consideration of the above issues ultimately leads to a completely general framework that outperforms unsupervised link prediction methods by more than 30% AUC.
Dimerization Determines Substrate Specificity of a Bacterial Prenyltransferase (2012)

We have identified the native dimer interface of heptaprenylglyceryl phosphate synthase PcrB from the bacterium Bacillus subtilis and analyzed the significance of oligomer formation for stability and catalytic activity. Computational methods predicted two different surface regions of the PcrB protomer that could be responsible for dimer formation. These bona fide interfaces were assessed both in silico and experimentally by the introduction of amino acid substitutions that led to monomerization, and by incorporation of an unnatural amino acid to allow cross-linking of the two protomers. The results showed that, in contrast to previous assumptions, PcrB uses the same interface for dimerization as the homologous geranylgeranylglyceryl phosphate synthase from Archaea. Thermal unfolding demonstrated that the monomeric proteins are only slightly less stable than wild-type PcrB. However, activity assays showed that monomerization limits the length of accepted polyprenyl pyrophosphates to three isoprene units, whereas the native PcrB substrate contains seven isoprene entities. We provide a plausible hypothesis as to how dimerization determines substrate specificity of PcrB.
Organic Light‐Emitting Diodes Based on Silandiol‐Bay‐Bridged Perylene Bisimides (2022)

Abstract Perylene bisimides (PBIs) are among the best fluorophores but have to be enwrapped for optoelectronic applications by large and heavy substituents to prevent their ππ‐stacking, which is known to accelerate non‐radiative decay processes in the solid state. Here, light‐weight di‐ tert ‐butylsilyl groups are introduced to bridge 1,12‐dihydroxy and 1,6,7,12‐tetrahydroxy PBIs to afford sublimable dyes for vacuum‐processed optoelectronic devices. For both new compounds, this substitution provides a twisted and shielded perylene π‐core whose, via OSiObridges, rigid structure affords well‐resolved absorption and emission spectra with strong fluorescence in solution, as well as in the solid state. The usefulness of these dyes for vacuum‐processed optoelectronic devices is demonstrated in organic light‐emitting diodes (OLEDs) that show monomer‐like emission spectra and high maximum external quantum efficiency (EQE max ) values of up to 3.1% for the doubly silicon‐bridged PBI.
Covalently Cross-Linked Elastomers with Self-Healing and Malleable Abilities Enabled by Boronic Ester Bonds (2018)

Covalently cross-linked rubbers are renowned for their high elasticity that play an indispensable role in various applications including tires, seals, and medical implants. Development of self-healing and malleable rubbers is highly desirable as it allows for damage repair and reprocessability to extend the lifetime and alleviate environmental pollution. Herein, we propose a facile approach to prepare permanently cross-linked yet self-healing and recyclable diene-rubber by programming dynamic boronic ester linkages into the network. The network is synthesized through one-pot thermally initiated thiol-ene "click" reaction between a novel dithiol-containing boronic ester cross-linker and commonly used styrene-butadiene rubber without modifying the macromolecular structure. The resulted samples are covalently cross-linked and possess relatively high mechanical strength which can be readily tailored by varying boronic ester content. Owing to the transesterification of boronic ester bonds, the samples can alter network topologies, endowing the materials with self-healing ability and malleability.
A fast FPGA based coprocessor supporting hard real-time search (2002)

In their work on dual port memories S. Cittolin and A. Fucci et al. (1995) describe a design approach for programmable message driven multi port memories (DPMs) with a high throughput (100 MByte/s). The design for nearly sequential requests (typical for some data acquisition systems (DAC)) causes accessing problems for more general applications. Considering hard real time requirements of DAC systems, the paper proposes two hardware implemented (based on FPGA technology) coprocessor architectures for searching in the file descriptor table of the dual port memory and compares them according to implementation costs and performance. Additionally the used searching strategy was implemented on the TI DSP C40 and the performance was compared to the hardware implementation. The examined hardware strategy is independent from the rest of the dual port memory and can therefore also be integrated into other computer systems as a generic searching coprocessor.