gebhart/patrepeval huggingface dataset:
Energy- and electron-transfer quenching of surfactant trans-stilbenes in supported multilayers: the use of hydrophobic substrate chromophores to determine short-range distance dependence in assemblies (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnergy- and electron-transfer quenching of surfactant trans-stilbenes in supported multilayers: the use of hydrophobic substrate chromophores to determine short-range distance dependence in assembliesWilliam F. Mooney and David G. WhittenCite this: J. Am. Chem. Soc. 1986, 108, 19, 5712–5719Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/ja00279a009https://doi.org/10.1021/ja00279a009research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Growth rate alterations of human colorectal cancer cells by 157 gut bacteria (2020)

Several bacteria in the human gut microbiome have been associated with colorectal cancer (CRC) by high-throughput screens. In some cases, molecular mechanisms have been elucidated that drive tumorigenesis, including bacterial membrane proteins or secreted molecules that interact with the human cancer cells. For most gut bacteria, however, it remains unknown if they enhance or inhibit cancer cell growth. Here, we screened bacteria-free supernatants (secretomes) and inactivated cells of over 150 cultured bacterial strains for their effects on cell growth. We observed family-level and strain-level effects that often differed between bacterial cells and secretomes, suggesting that different molecular mechanisms are at play. Secretomes of <i>Bacteroidaceae, Enterobacteriaceae</i>, and <i>Erysipelotrichaceae</i> bacteria enhanced cell growth, while most <i>Fusobacteriaceae</i> cells and secretomes inhibited growth, contrasting prior findings. In some bacteria, the presence of specific functional genes was associated with cell growth rates, including the virulence genes TcdA, TcdB in <i>Clostridiales</i> and FadA in <i>Fusobacteriaceae</i>, which both inhibited growth. <i>Bacteroidaceae</i> cells that enhanced growth were enriched for genes of the cobalamin synthesis pathway, while <i>Fusobacteriaceae</i> cells that inhibit growth were enriched for genes of the ethanolamine utilization pathway. Together, our results reveal how different gut bacteria have wide-ranging effects on cell growth, contribute a better understanding of the effects of the gut microbiome on host cells, and provide a valuable resource for identifying candidate target genes for potential microbiome-based diagnostics and treatment strategies.
Disruption studies of a Candida albicans gene, ELF1: a member of the ATP-binding cassette family (1998)

A 3.6 kb gene (ELF1) with homology to the ATP-binding cassette (ABC) gene family has been isolated from genomic libraries of Candida albicans. Members of this gene family include both membrane transport proteins which confer a drug-resistance phenotype, and proteins whose functions are associated with protein translation. ELF1 (Elongation Like Factor) showed greatest homology with a Saccharomyces cerevisiae ORF (YPL226W), whose function is unknown, and lower homology with fungal elongation factor 3 (EF-3) genes. In comparison, homology with a gene conferring a drug-resistant phenotype (CDR1) was low. To understand the function of ELF1 in C. albicans, gene-knockout experiments were conducted using the hisG-URA3-hisG disruption cassette. Both single-copy (heterozygote) and double-disrupted strains in ELF1 were isolated. Phenotypically, the disrupted strains grew more slowly than wild-type and produced a mixture of large, irregular cells and apparently normal cells.
Gastrointestinal and Hepatic Complications (2015)

The frequency and severity of intestinal and liver complications of hematopoietic cell transplantation (HCT) have declined steeply over the last decade. This chapter mentions now rare complications so that the lessons of the past are not completely forgotten. More emphasis is given to problems that are still common, such as anorexia following conditioning therapy; acute graft-versus-host disease (GVHD), protracted acute GVHD, and liver presentations of GVHD; adenovirus, cytomegalovirus, and norovirus infections; and problems in long-term transplant survivors. Early signs of acute GVHD include loss of appetite, absence of pleasure from eating, and satiety, often followed by nausea and vomiting, especially when more subtle signs are not investigated. Cytomegalovirus (CMV) infections in the gastrointestinal tract are usually diagnosed between 50 and 150 days after HCT. Endocrine dysfunction can result from iron deposition in the anterior pituitary, pancreas, and thyroid.
Constructing and Compressing Frames in Blockchain-based Verifiable Multi-party Computation (2019)

In previous work, we proposed a scalable multi-party verification scheme for expensive iterative computations on a Blockchain substrate by appropriate storage and endorsement of frames of iterates. In this work, we extend the framework to verify sets of complete computations with different unordered hyperparameters and develop frame ordering and compression algorithms to enable scalability in the system. We illustrate the efficacy of the proposed approach by verifying the OpenMalaria epidemiological simulation.
Sarcolipin, the Shorter Homologue of Phospholamban, Forms Oligomeric Structures in Detergent Micelles and in Liposomes (2001)

The human 31-amino acid integral membrane protein sarcolipin (SLN), which regulates the sarcoplasmic reticulum Ca-ATPase in fast-twitch skeletal muscle, was chemically synthesized. Appropriate synthesis and purification strategies were used to achieve high purity and satisfactory yields of this hydrophobic and poorly soluble protein. Structural and functional properties of SLN were analyzed and compared with the homologous region of human phospholamban (PLB) comprising residues Ala(24)-Leu(52) (PLB-(24-52)), the regulatory protein of the cardiac sarcoplasmic reticulum Ca-ATPase. Circular dichroism spectroscopy showed that SLN is a predominantly alpha-helical protein and that the secondary structure is highly resistant to SDS and thermal denaturation. In this respect SLN is remarkably similar to PLB-(24-52). However, SLN is monomeric in SDS gels, whereas PLB-(24-52) shows a monomer-pentamer equilibrium typical for native PLB. Analytical ultracentrifugation experiments revealed that SLN oligomerizes in the presence of the nonionic detergents octylpolyoxyethylene and octyl glucoside in a concentration-dependent manner. No plateau was observed, and a pentameric state was only reached at much higher protein concentrations compared with PLB-(24-52). Chemical cross-linking showed that also in liposomes SLN has the ability to self-associate to oligomers. PLB-(24-52) specifically oligomerized to pentamers in the presence of octylpolyoxyethylene as well as in liposomes at low protein concentrations. In the presence of octylpolyoxyethylene pentamers were the main oligomeric species, whereas in liposomes monomers and dimers were predominant. Increasing the protein concentration led to self-association of PLB-(24-52) pentamers in the presence of octylpolyoxyethylene. Functional reconstitution of Ca-ATPase with PLB-(24-52) and SLN in liposomes showed that both proteins regulate the Ca-ATPase in a similar manner.
Multiple dose pharmacokinetics of inhaled loxapine in subjects on chronic, stable antipsychotic regimens (2015)

This randomized, double-blind, placebo-controlled, parallel-group study was to determine the pharmacokinetic characteristics, safety, and tolerability of multiple doses of inhaled loxapine aerosol in subjects on a stable, oral, chronic antipsychotic regimen. Loxapine was delivered by means of a unique thermally generated aerosol comprising drug particles of a size designed for deep lung delivery and absorption. Thirty-two subjects were randomized 1:1:1:1 to receive inhaled loxapine (total doses of 15, 20, or 30 mg) or inhaled placebo administered in 3 divided doses, given 4 hours apart. Following inhalation, the median Tmax was 2 minutes, and concentrations declined to about half Cmax approximately 5 minutes later across the 3 dose levels. The dose proportionality across data from this study combined with data from the single-dose study showed a slope (90%CI) of log AUCinf versus log dose of 0.818 (0.762-0.875) across the 8 doses (n = 60 subjects) studied, indicating reasonable dose proportionality. The most common adverse events were cough (3 of 32, 9%), sedation (3 of 32, 9%), and dysgeusia (2 of 32, 6%). The inhalation of multiple doses of inhaled loxapine were well tolerated in study subjects and provided a safe, well-tolerated means for rapidly and reliably achieving therapeutic plasma concentrations of loxapine. ClinicalTrials.gov identifier: NCT00555412.
Improvement of a Low-Reynolds-Number Second Moment Closure and Its Application to Rotating Turbulent Channel Flows. (2001)

A low-Reynolds-number second moment closure is improved with the aid of DNS data and applied to turbulent channel flows with a spanwise rotation. Shima’s pressure strain model is refined and a multiple source model is introduced for the exact ε equation. Computational results for the turbulent plane channel flows rotating in orthogonal mode are compared with the DNS, LES and experimental data. The present second moment closure achieves a level of agreement with DNS data similar to those for the non-rotating flow cases. In particular, it yields the improved performance in predicting the distributions of ε in the near wall sublayer.
Flow-Control-Induced Vibrations Using Pulsed DBD Plasma Actuators (2012)

This paper describes flow-control-induced vibrations using pulsed dielectric barrier discharge (DBD) plasma actuators, in which boundary layer separation on a structure is actively controlled to produce periodic loads that lead to its vibration. The concept is intended for energy generation and is demonstrated experimentally using a one-degree-offreedom pivoted cylindrical body, mounted vertically within a blow-down wind tunnel. Subcritical Reynolds numbers, less than 10 5 , were considered where typical shedding frequencies were several times larger than the system natural frequency. Static deflection experiments were performed to determine the maximum imposed aerodynamic loads as a function of control parameters and these were complimented with flow-field measurements. Periodic loading of the cylinder was achieved by periodic modulation of the actuator. Large amplitude oscillations were observed when the modulation frequency was close to the system natural frequency. In contrast to natural vortex induced vibration, the large amplitude oscillations were achieved by alternating dynamic separation and attachment of the boundary layer. Estimation of the transient loads was performed using a system identification technique and the power generated by the system was estimated on the basis of a piecewise linear model. Peak estimated power coefficients were relatively small (0.042) but the system is amenable to up-scaling because the power coefficient increases with the squareroot of the system dimensions.
Creation of an acute tricuspid regurgitation and tricuspid annular dilatation using cardioport imaging technique in an animal model (2010)

Objectives: Experimental models of tricuspid regurgitation (TR) are necessary to study the feasibility of surgical placement of annuloplasty ring. Our aim is to develop an appropriate simple and reproducible experimental model for creation of tricuspid regurgitation.
Topical CpG adjuvant enhances immune response to subcutaneous antigen by modulating the cutaneous lymph node environment (P4267) (2013)

Abstract Current vaccines are mainly administered by intramuscular route but the skin harbors many immune cells and can be used as a site of immunization. Topical CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 (TLR9) agonist, improves humoral and cell-mediated immune responses to locally injected protein-based vaccines in mice but the mechanisms are still unclear. Topical CpG ODN is internalized by CD11c+ cells that are detected within the skin draining lymph nodes (SLN) at 48 hours post treatment. Ablation of TLR9 in the hematopoietic compartment of bone marrow chimeric mice abrogates antigen-specific CD8+ T cells production. TLR9 ablation in the stromal compartment also decreases topical CpG adjuvant effect. Topical CpG ODN differentially modulates the environment of SLN compared to subcutaneous administration within 24 hours of treatment (with 4-7 fold increased expression of 4 genes: Ccl4, Cxcl3, Ifng and Il11). A higher proportion of antigen-specific CD4+ T cells in the SLN express tissue-homing molecules (P- and E-selectin ligand) when adjuvant is administered topically compared to subcutaneously. Egress of lymphocytes from SLN is necessary for optimal CpG adjuvant effect using a contact hypersensitivity model. We propose that topical CpG ODN activates stromal cells as well as hematopoietic-derived cells in the skin, to subsequently modulate the environment of SLN. These changes enhance protective humoral and cell-mediated immune responses.
Three-year patient-reported visual function outcomes in diabetic macular edema managed with ranibizumab: the RESTORE extension study (2015)

ClinicalTrials.gov: NCT00687804 and NCT00906464.
Orientation Dependence of Twinning in Commercially Pure Titanium (1990)

Orientation dependence of twinning in commercially pure titanium was determined in both single crystals deformed in tension or compression and polycrystals deformed in tension. {\bar1012} and {11\bar22} twins in single crystals, and {\bar1012}, {11\bar21} and {11\bar22} twins in polycrystals occurred depending on the sense and direction of applied stress. It was observed that twinning generally occurred on a highly stressed system with a large Schmid factor for twinning. However, {\bar1012} twins which have smaller Schmid factors than those for {11\bar21} twins operated predominantly in the region where the angle between the tensile axis and basal pole is about 30∼40°. This suggests that {\bar1012} twins are formed more easily than {11\bar21} twins. The planar anisotropy of work hardening, which has been reported in tensile deformation of commercially pure titanium sheet, is satisfactorily explained by the orientation dependence of twinning presented in this study.
The effect of full-azimuth local angle domain (LAD) imaging on the study of terrigenous and carbonate reservoirs under complex in-situ conditions at an eastern Siberian field (2017)

The EarthStudy 360 full-azimuth local angle domain (LAD) imaging and analysis technology, developed by Paradigm, appeared on the geophysical services market in 2012. GazpromNeft NTC, a high-tech company that strives to incorporate the most advanced systems into its operations, did not let this opportunity pass by. A pilot project to test LAD imaging was undertaken in 2014. The study’s most significant findings were anisotropy intensity and direction determinations in terrigenous and carbonate reservoirs, and improved acoustic impedance convergence calculated on a combination of advanced technology results and GIS data. In 2015 GazpromNeft NTC used the technology to assess 3D full-azimuth angle domain survey data in an Eastern Siberian field. Historically, Eastern Siberia has been one of the most difficult areas for seismic studies attempting to prospect for and predict reservoir properties. Complex relief and subsurface velocity heterogeneity in both vertical and lateral directions creates problems for seismic survey operations and for seismic data processing. The greatest challenges occur in depth processing, where specific complexities hinder the development of a depth/velocity model, beginning with near-surface formations and the top portion of the geologic profile. Local lithological variations in the lateral direction, accompanied by the surface exposure of rocks of various ages and lithological characteristics (from carbonates to clays, salt-bearing strata, and sometimes trapped intrusions) make it necessary to develop complex velocity models and apply full-azimuth depth surveys which traditional approaches and migrations, based on the Kirchhoff integral, cannot provide. Cambrian, Jurassic and Quaternary rocks with P-wave velocities of 5000-5500 m/s, 3000-3500 m/s, and 900-1200 m/s, respectively, are exposed at the surface of the survey area.
Satellite cells in ageing: use it or lose it (2020)

Individuals that maintain healthy skeletal tissue tend to live healthier, happier lives as proper muscle function enables maintenance of independence and actuation of autonomy. The onset of skeletal muscle decline begins around the age of 30, and muscle atrophy is associated with a number of serious morbidities and mortalities. Satellite cells are responsible for regeneration of skeletal muscle and enter a reversible non-dividing state of quiescence under homeostatic conditions. In response to injury, satellite cells are able to activate and re-enter the cell cycle, creating new cells to repair and create nascent muscle fibres while preserving a small population that can return to quiescence for future regenerative demands. However, in aged muscle, satellite cells that experience prolonged quiescence will undergo programmed cellular senescence, an irreversible non-dividing state that handicaps the regenerative capabilities of muscle. This review examines how periodic activation and cycling of satellite cells through exercise can mitigate senescence acquisition and myogenic decline.
Unraveling Latch Locking Using Machine Learning, Boolean Analysis, and ILP (2023)

Logic locking has become a promising approach to provide hardware security in the face of a possibly insecure fabrication supply chain. While many techniques have focused on locking combinational logic (CL), an alternative latch-locking approach in which the sequential elements are locked has also gained significant attention. Latch (LAT) locking duplicates a subset of the flip-flops (FF) of a design, retimes these FFs and replaces them with latches, and adds two types of decoy latches to obfuscate the netlist. It then adds control circuitry (CC) such that all latches must be correctly keyed for the circuit to function correctly. This paper presents a two-phase attack on latch-locked circuits that uses a novel combination of deep learning, Boolean analysis, and integer linear programming (ILP). The attack requires access to the reverse-engineered netlist but, unlike SAT attacks, is oracle-less, not needing access to the unlocked circuit or correct input/output pairs. We trained and evaluated the attack using the ISCAS’89 and ITC’99 benchmark circuits. The attack successfully identifies a key that is, on average, 96.9% accurate and fully discloses the correct functionality in 8 of the tested 19 circuits and leads to low function corruptibility (less than 4%) in 3 additional circuits. The attack run-times are manageable.
Author response: Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding (2015)

The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
Short association bundle atlas based on inter-subject clustering from HARDI data (2016)

This paper is focused on the study of short brain association fibers. We present an automatic method to identify short bundles of the superficial white matter based on inter-subject hierarchical clustering. Our method finds clusters of similar fibers, belonging to the different subjects, according to a distance measure between fibers. First, the algorithm obtains representative bundles and subsequently we perform an automatic labeling based on the anatomy, of the most stable connections. The analysis was applied to two independent groups of 37 subjects. Results between the two groups were compared, in order to keep reproducible connections for the atlas creation. The method was applied using linear and non-linear registration, where the non-linear registration showed significantly better results. A final atlas with 35 bundles in the left hemisphere and 27 in the right hemisphere from the whole brain was obtained. Finally results were validated using the atlas to segment 26 new subjects from another HARDI database.
Energy Dispersive X-Ray Fluorescence Spectrometry Using Pulsed X-Ray Excitation (1975)

An energy dispersive X-ray fluorescence spectrometer using pulsed X-ray excitation has been developed for use in large-scale environmental analysis programs. A grid controlled X-ray tube is coupled with variable secondary fluorescence targets to analyze for a wide variety of elements with almost optimum sensitivity. The operation of the pulsed tube in a feedback loop with the semiconductor detector spectrometer results in a substantial increase in output counting rates without pile-up. The loop functions by turning off the excitation immediately upon detection of an event by the spectrometer. Pileup events are virtually eliminated and the X-ray tube's available anode power is better utilized. The electronic control of this feedback mode results in some unique features in the response of the system to varying sample mass. These features are discussed in detail. Experimental results for sensitivity and accuracy over the range of elements measured are presented. Early operating experience with the unit indicates increases of counting rates of a factor of five compared with similar conventional systems.
Automatic Packing Mechanism for Simplification of the Scheduling in Profinet IRT (2015)

In order to support very small cycle times, Profinet isochronous real-time (IRT) was improved by implementing the dynamic frame packing (DFP) mechanism. It turned out that DFP is relatively efficient, but it still has two crucial drawbacks. The complex scheduling has to be recalculated every time the network structure is modified. Furthermore, DFP only operates efficiently in line topology. This study presents a proposal for further improvements of Profinet IRT by implementing an automatic packing mechanism (APM). The main advantage of APM lies in the fact that a dedicated scheduling algorithm is not required. Furthermore, APM achieves approximately the same performance as DFP in line topology, but it has a distinctive advance in star or tree topologies. This paper also presents experimental validation results that prove the functionality of the approach. APM could be implemented with only minor modifications of the media access control (MAC) and physical layer (PHY) hardware to improve the flexibility of Profinet IRT.
Acoustical properties of macroscopically inhomogeneous porous medium (2012)

International audience