gebhart/patrepeval huggingface dataset:
Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. (1996)

1. The hypothesis that cellular hydration state modulates muscle glycogen synthesis was tested by measuring the incorporation of [14C]glucose into glycogen (glycogen synthesis) in primary rat myotubes after experimentally induced volume changes. 2. Glycogen synthesis in myotubes increased (by 75%, P < 0.01) after swelling induced by 60 min exposure to hyposmotic media (170 mosmol kg-1) relative to isosmotic control (300 mosmol kg-1) values, it decreased (by 31%, P < 0.05) after shrinkage induced by 60 min exposure to hyperosmotic (430 mosmol kg-1) media. Myotube 2-deoxy-D-glucose (0.05 mM) uptake was unaffected by changes in external osmolality. 3. Wortmannin (100 nM; 60 min), a phosphatidylinositol 3-kinase inhibitor, decreased basal glycogen synthesis by 28% whereas rapamycin (100 nM; 60 min), which blocks the activation of p70 S6 kinase, had no effect. Both wortmannin (100 nM; 60 min) and rapamycin (100 nM; 60 min) blocked the changes in glycogen synthesis resulting from hypo- and hyperosmotic exposure. 4. Myotube glycogen synthesis is modulated by volume changes independently of changes in glucose uptake. The phenomenon may be physiologically important in promoting glycogen storage during circumstances of myofibrillar swelling, e.g. after feeding or exercise.
Optical pumping of rare-gas metastable atom beams with a frequency-modulated multimode dye laser (1986)

Very efficient stable optical pumping of an argon metastable atom beam is achieved using a frequency-modulated multimode dye laser. Frequency modulation is accomplished by rapidly oscillating the laser output coupler using a piezoelectric translator. This technique appears attractive for use in optically pumping a wide variety of atomic species.
Open Reduction and Internal Fixation of 117 Tibial Plateau Fractures (2004)

This retrospective study evaluated the surgical management of 117 tibial plateau fractures treated between 1990 and 1998. At last patient follow-up, results were rated good to excellent in 94, fair in 13, and poor in 10 cases. Follow-up radiographs showed degenerative changes in the lateral compartment in 29 cases. Other complications included five wound infections, two deep venous thromboses, five delayed unions, and three nonunions. Operative treatment of tibial plateau fractures is recommended as it enables better alignment, meniscal access, and other soft-tissue injury repair.
Speaker Recognition from Raw Waveform with SincNet (2018)

Deep learning is progressively gaining popularity as a viable alternative to i-vectors for speaker recognition. Promising results have been recently obtained with Convolutional Neural Networks (CNNs) when fed by raw speech samples directly. Rather than employing standard hand-crafted features, the latter CNNs learn low-level speech representations from waveforms, potentially allowing the network to better capture important narrow-band speaker characteristics such as pitch and formants. Proper design of the neural network is crucial to achieve this goal.This paper proposes a novel CNN architecture, called SincNet, that encourages the first convolutional layer to discover more meaningful filters. SincNet is based on parametrized sinc functions, which implement band-pass filters. In contrast to standard CNNs, that learn all elements of each filter, only low and high cutoff frequencies are directly learned from data with the proposed method. This offers a very compact and efficient way to derive a customized filter bank specifically tuned for the desired application.Our experiments, conducted on both speaker identification and speaker verification tasks, show that the proposed architecture converges faster and performs better than a standard CNN on raw waveforms.
P-73ALCOHOLIC CARDIOMYOPATHY: A TRANSLATIONAL MODEL IN RATS (2015)

Background.. Alcoholi cardiomyopathy (AC) is a frequent complication of alcohol dependency. Patients with AM have a twice higher risk of sudden cardiac death as compared to non-drinkers. The aim of this work was to develop translational model of ACM in rats in order to investigate cardiac dysfunction in ACM and to develop pharmaceuticals for prevention sudden cardiac death in this disease. Methods. Adult rats were given 10% ethanol as the only source of fluid and ad libitum access to food during 24 weeks.
Technical Note—The Multiperiod Knapsack Problem (1981)

In the multiperiod knapsack problem the decision maker faces a horizon of m periods. Associated with each period are a number of types of items, each with a value and weight. Subject to the requirement that the cumulative capacity of the knapsack in each period i cannot be exceeded by items chosen in periods 1, …, i, the decision maker chooses the most valuable knapsack possible. A branch and bound algorithm exploits the special structure of the multiperiod knapsack problem by calculating bounds by the direct solution of linear programs with m constraints in 0(m) operations. Computational experience is reported on problems ranging in size up to 200 constraints and 1,000 general integer variables.
Artifact Lifecycle Discovery (2013)

Artifact-centric modeling is a promising approach for modeling business processes based on the so-called business artifacts - key entities driving the company's operations and whose lifecycles define the overall business process. While artifact-centric modeling shows significant advantages, the overwhelming majority of existing process mining methods cannot be applied (directly) as they are tailored to discover monolithic process models. This paper addresses the problem by proposing a chain of methods that can be applied to discover artifact lifecycle models in Guard-Stage-Milestone notation. We decompose the problem in such a way that a wide range of existing (non-artifact-centric) process discovery and analysis methods can be reused in a flexible manner. The methods presented in this paper are implemented as software plug-ins for ProM, a generic open-source framework and architecture for implementing process mining tools.
Computer animation of human walking: a survey (1999)

This paper surveys the set of techniques developed in computer graphics for animating human walking. First we focus on the evolution from purely kinematic ‘knowledge-based’ methods to approaches that incorporate dynamic constraints or use dynamic simulations to generate motion. Then we review the recent advances in motion editing that enable the control of complex animations by interactively blending and tuning synthetic or captured motions. Copyright © 1999 John Wiley & Sons, Ltd.
Studies on annealing and quenching of strontium barium niobate (SBN) single crystals: A-site cation ordering-disordering effect (1989)

Abstract Quenching and annealing studies have been carried out to investigate the effects of the A-site occupancy in the tungsten bronze structure on the polarization, pyroelectric coefficient, dielectric permittivity, and phase transition (Curie temperature range) behavior of ferroelectric relaxor Sr1−xBa x Nb2O6 (1−x = 0.75, 0.60, 0.50) single crystals. Quenching possibly generates a random distribution of vacancies between A1 and A2 sites and enhances the ordering of the cations in A-site. As a consequence of that, a Tc increase of as much as about 30°C above the Tc of non-quenched state has been observed. Quenching at a higher temperature, i.e., approximately about 1000°C results in reducing the ordering of the A-site because of random distribution of Sr2+, Ba2+, as well as vacancies. A continuous Tc increase accompanied by a decrease in dielectric permittivity and a broadened phase transition is reported and is believed to be due to strain built up because of energetically unfavored distribution of Ba2+ in A1. By suitable annealing, the original Tc and dielectric property are essentially reproduced. However, quenching at around 1000°C generates a new anomaly related to Tc , which is detected by both Raman measurement and Byer and Roundy pyroelectric measurement. This new anomaly still exists even after carefully annealing. It is suggested that both vacancy and cation distribution, as well as associated strain built-up, play the major role in the phase transition behavior.
ChemInform Abstract: “Stretching” the Energy Landscape of Oxides‐Effects on Electrocatalysis and Diffusion (2014)

Abstract Review: 103 refs.
A60 THE INCIDENCE OF INFLAMMATORY BOWEL DISEASE IS DECREASING IN SASKATCHEWAN: A POPULATION-BASED COHORT STUDY (2020)

Abstract Background Canada has one of the highest inflammatory bowel disease (IBD) incidence rates worldwide, although within Canada rates vary. Evidence show increasing incidence rates of IBD in Ontario (i.e. adults aged 30–60), stable in Alberta and decreasing in Manitoba. Additionally, higher incident rates of IBD have been identified among urban regions compared to rural regions. There is limited data on the incidence of IBD in Saskatchewan. Aims The study objectives were to 1) estimate IBD incidence rates in Saskatchewan from 1999 to 2016, and 2) test for differences in IBD incidence rates for rural and urban regions of Saskatchewan. Methods A population-based study was conducted using linked provincial administrative health databases. Individuals age 18+ old with newly diagnosed Crohn’s disease (CD) or ulcerative colitis (UC) were identified using a validated case definition. Generalized linear models with a negative binomial distribution were used to estimate incidence rates and incidence rate ratios (IRR) adjusted for age group, sex, and rurality with 95% confidence intervals (95%CI). Results In total, 4,908 newly diagnosed individuals with IBD were included. The average annual incidence rate of IBD decreased from 75 (95%CI 67–84) per 100,000 people in 1999 to 15 (95%CI 12–18) per 100,000 population in 2016. This decrease was evident in both UC (from 36/100,000 [95%CI 31–42] in 1999 to 6/100,000 [95%CI 4–8] in 2016) and CD (37/100,000 [95%CI 32–42] in 1999 to 8/100,000 [95%CI 6–10] in 2016). A significant decline of 6.9% (95%CI 6.2–7.6) in the average annual incidence of IBD was estimated between 1999 and 2016 (see Figure 1). Urban residents had a greater overall risk of IBD (IRR=1.19, 95%CI 1.11–1.27) than rural residents. This risk difference was statistically significant for CD (IRR=1.25, 95%CI 1.14–1.36), but not UC (IRR=1.08, 95%CI 0.97–1.19). Conclusions A decreasing trend in IBD incidence in Saskatchewan was identified after adjusting for age group, sex, and rural/urban region of residence. Around 150 new cases of IBD are still diagnosed annually in Saskatchewan, but this estimate is lower than estimates from other provinces. Urban dwellers have a 25% higher risk of CD onset compared to their rural counterparts. This finding could suggest the presence of specific risk factors in urban settings that require further investigation. Health care providers and decision-makers should plan IBD-specific health care programs taking into account these specific IBD rates in Saskatchewan. Funding Agencies College of Medicine, University of Saskatchewan
A static and dynamic model for a silicon carbide power MOSFET (2009)

Static C-V and I-V characteristics related dynamic behaviors of power MOSFET. Models for Si power MOSFET have already been obtained through the previous studies. Based on the model, a model for SiC power MOSFET is proposed that includes the physics of semiconductor, physical structures of the device, and extracted parameters from the measured C-V characteristics. The static I-V characteristics are also discussed with the C-V characteristics. It is clearly shown that the simulated results in switching behavior of the proposed model coincide with experimental results suitably in some conditions.
ChemInform Abstract: ELECTRICAL CONDUCTION IN SINTERED α‐ANTIMONY OXIDE (SB2O4) (1983)

Abstract Im Hinblick auf die Anwendung von Sb‐Oxiden als Additive zu Halbleitern wurden Leitfähigkeit und Thermokraft (Seebeck‐Koeffizienten) von α‐Sb2O4 bei 250‐780°C gemessen.
D.STVL.9 - Ongoing Research Areas in Symmetric Cryptography (2008)

This report gives a brief summary of some of the research trends in symmetric cryptography at the time of writing (2008). The following aspects of symmetric cryptography are investigated in this report: • the status of work with regards to different types of symmetric algorithms, including block ciphers, stream ciphers, hash functions and MAC algorithms (Section 1); • the algebraic attacks on symmetric primitives (Section 2); • the design criteria for symmetric ciphers (Section 3); • the provable properties of symmetric primitives (Section 4); • the major industrial needs in the area of symmetric cryptography (Section 5).
SRv6 for Deterministic Networking (DetNet) (2019)

Deterministic Networking provides service with low jitter, bounded
latency and low loss rate, using technologies of explicit route,
resource reservation and service protection.This document specifies
how to implement Deterministic Networking (DetNet) in a SRv6 Network.
A model of antigen processing improves prediction of MHC I-presented peptides (2020)

Summary Computational prediction of the peptides presented on MHC class I proteins is an important tool for studying T cell immunity. The data available to develop such predictors has expanded with the use of mass spec to identify naturally-presented MHC ligands. In addition to elucidating binding motifs, the identified ligands also reflect the antigen processing steps that occur prior to MHC binding. Here, we developed an integrated predictor of MHC I presentation that combines new models for MHC I binding and antigen processing. Considering only peptides first predicted by the binding model to bind strongly to MHC, the antigen processing model is trained to discriminate published mass spec-identified MHC I ligands from unobserved peptides. The integrated model outperformed the two individual components as well as NetMHCpan 4.0 and MixMHCpred 2.0.2 on held-out mass spec experiments. Our predictors are implemented in the MHCflurry package, version 1.6.0 ( github.com/openvax/mhcflurry ).
Activity of BC-3781, a Novel Pleuromutilin Compound, Tested against Clinical Isolates of MRSA, Including Molecularly Characterized Community-Acquired and Hospital-Associated Strains (2010)

Background: BC-3781 has a unique mode of action which interferes with bacterial protein synthesis without cross-resistance (R) to other antimicrobial classes. Pleuromutilins inhibit protein synthesis by binding the peptidyl transferase component of the 50S subunit of ribosomes. We tested the activity of BC-3781 against a diverse collection of S. aureus. Methods: Antimicrobial activity of BC-3781 and comparators was determined against 924 non-duplicate S. aureus: 671 resistant (MRSA) and 253 susceptible (MSSA) to oxacillin. The MRSA collection includes strains from 2010 (103), 2009 (211), 2008 (110) and 2006 (102) as well as molecularly characterized strains from various years and geographic regions. The strains were cultured predominately from USA and European hospitals and tested for susceptibility against BC-3781 and comparators by the CLSI broth microdilution method (M07-A8). Results: BC-3781 exhibited potent activity against MRSA with a MIC mode of 0.12 µg/mL for all subsets tested. Most MIC values (>98%) were in the range of 0.06 to 0.25 µg/mL. BC-3781 activity remained constant during the study period and was not affected by SCCmec type. USA300 (45) and USA400 (5) MRSA isolates were very susceptible to BC-3781. BC-3781 activity against MRSA was similar to that exhibited for MSSA. Conclusions: BC-3781 demonstrated potent in vitro activity against a large and diverse collection of MRSA. BC-3781 displayed a narrow MIC range and its activity was not adversely influenced by R to other antimicrobial classes. These results indicate that BC-3781 should be further evaluated for treatment of MRSA infections.
Aerodynamic Blade Row Interactions in an Axial Compressor: Part I — Unsteady Boundary Layer Development (2003)

This two-part paper presents experimental investigations of unsteady aerodynamic blade row interactions in the first stage of the four-stage Low-Speed Research Compressor of Dresden. Both the unsteady boundary layer development and the unsteady pressure distribution of the stator blades are investigated for several operating points. The measurements were carried out on pressure side and suction side at midspan. In part I of the paper the investigations of the unsteady boundary layer behaviour are presented. The experiments were carried out using surface-mounted hot-film sensors. Additional information on the time-resolved flow between the blade rows were obtained with a hot-wire probe. The unsteady boundary layer development is strongly influenced by the incoming wakes. Within the predominantly laminar boundary layer in the front part of the blade a clear response of the boundary layer to the velocity and turbulence structure of the incoming wakes can be observed. The time-resolved structure of the boundary layer for several operating points of the compressor is analyzed in detail. The topic “calmed regions”, which can be coupled to the wake passing, is discussed. As a result an improved description of the complex boundary layer structure is given.
Update on prostaglandin analogs (2003)

Prostaglandin analogs are a novel class of intraocular-lowering medications used primarily for the treatment of glaucoma. These topical medications reduce intraocular pressure primarily by enhancing uveoscleral outflow. The recent literature has enhanced our understanding of the mechanism of action, efficacy, and safety of these agents and has allowed us to better understand the differences between the three commonly used once-daily medications.
New standards, new PIF, new mission (1999)

T he commission published the fourth edition of the accreditation standards in October 1999. Each time these standards are changed or revised, the program information form (PIF) also is updated so that each numbered question corresponds directly with a standard of the same number. Standards may change not only in content but also in format, so it is very important to be working from the correct and current PIF. As mentioned in a previous article, we provide a 6month grace period to make the transition to the new standards. Therefore, a service has until April 30, 2000, to return a PIF that corresponds to the 1997 accreditation standards. After April 30, the 1999 accreditation standards will be in effect, and all applicants must complete the 1999 PIF, which was available as of October 1, 1999. In developing new standards and revising old ones, the CAMTS standards committee reviews accident reports from the NTSB to see if any weak areas might be addressed by a standard or more defined criteria. The board of directors also tracks the most commonly cited contingencies to see if a problem exists with the way a standard is interpreted or worded or if it should be replaced or eliminated. Lastly, the board studies trends in the medical transport profession and tries to anticipate future standards of practice. During its July 1999 meeting, for example, the board voted to expand its mission once again because of the increasing number of medical transport services that are adding BLS and ALS ground services to their air and critical care ground transport systems. Therefore, you will see that the mission statement, goals, and the preamble in the 1999 accreditation standards refer to serving medical transport systems instead of specifying air and ground critical care. The Accreditation Standards Committee began work on a supplement for the 1999 standards to address the ground BLS and ALS components of medical transport systems. We expect this supplement will be available by spring of 2000. CAMTS then will be able to offer this added service so that, if a medical transport system provides BLS and ALS ground transport along with a critical care ground and/or an air medical service, it will be able to apply for CAMTS accreditation for all components of the service. The key word is system. Ground BLS/ALS services that are not associated with a critical care ground or air service will not be eligible for CAMTS accreditation. This most recent change resulted from conversations with program directors of transport systems who saw their programs evolving into full service ground and air transport systems to meet their patients' needs. Trends in health care and reimbursement issues have influenced new and creative ways to provide a quality service. The CAMTS board is open to your comments and suggestions and stands ready to meet the challenge of change. We will provide full details of the BLS/ALS ground addition in the next issue, r-Al
Science Case for the new High-Intensity Muon Beams HIMB at PSI (2021)

In April 2021, scientists active in muon physics met to discuss and work out the physics case for the new High-Intensity Muon Beams (HIMB) project at PSI that could deliver of order $10^{10}$\,s$^{-1}$ surface muons to experiments. Ideas and concrete proposals were further substantiated over the following months and assembled in the present document. The high intensities will allow for completely new experiments with considerable discovery potential and unique sensitivities. The physics case is outstanding and extremely rich, ranging from fundamental particle physics via chemistry to condensed matter research and applications in energy research and elemental analysis. In all these fields, HIMB will ensure that the facilities S$μ$S and CHRISP on PSI's High Intensity Proton Accelerator complex HIPA remain world-leading, despite the competition of muon facilities elsewhere.
Reversible ventricular arrythmia induced by dasatinib (2013)

Ventricular arrhythmias induced by dasatinib are rare events, but physicians in charge of chronic myeloid leukemia patients should be aware of such potential complications and the need for regular ECG controls during treatment with tyrosine kinase inhibitors.
Hydrogen passivation of a bulk donor defect (E c −0.36 eV) in GaAs (1982)

The passivation of a bulk donor defect (Ec –0.36 eV) in polycrystalline GaAs by reaction with atomic hydrogen has been observed using deep level transient spectroscopy. The concentration profile of the defect is presented as a function of the duration and temperature of the exposure to atomic hydrogen—when exposed for 3 h at 250 °C, 3×1015 donor defects cm−3 were passivated to a depth of ∼1.1 μm.
Amorphous carbon hermetically coated optical fibers (1988)

Reliability issues concerning optical waveguides for use in harsh environments have promoted interest in developing materials and processing techniques that overcome long-term aging effects which can degrade fiber performance. Two long-term reliability issues for silica-based optical waveguides are strength degradation by static fatigue and optical loss increases due to hydrogen diffusion into the lightguide structure.