gebhart/patrepeval huggingface dataset:
A.: Modeling of wedge-shaped anisotropic piezocomposite transducer for guided wave-based structural health monitoring (2016)

The guided wave (GW) field excited by a wedge-shaped, anisotropic piezocomposite transducer (APT), surface-bonded on an isotropic substrate is investigated with applica-tions to large area structural health monitoring (SHM). It is shown that this configuration is significantly more efficient than conventional designs in terms of electric current drawn to induced displacement amplitudes. The analysis is based on the three-dimensional equa-tions of elasticity, and the solution yields analytical expressions for the field variables in three separate spatial regions determined by the location of the transducer’s radial edges. In this study, the dynamics of the substrate and transducer are assumed uncoupled, and their interaction is modeled through surface tractions along the transducer’s edges. The excitation modes considered are harmonic and a Hann-modulated toneburst. A similar problem is modeled using three-dimensional finite element simulations, to assess the spa-tial and transient accuracy of the analytical solution. The results show good agreement over a wide range of radial and azimuthal positions, as well as good time resolution. The result-ing expressions are used to identify optimal harmonic excitation frequencies and actuator dimensions. The response of a wedge-shaped APT sensor and a rectangular piezoelec-tric sensor under the guided wave field excited by a wedge-shaped APT actuator is also investigated.
Excessive Daytime Sleepiness Is Associated with Changes in Salivary Inflammatory Genes Transcripts (2015)

Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A test that can reliably identify individuals that suffer from EDS is needed. In contrast to other methods, salivary biomarkers are an objective, inexpensive, and noninvasive method to identify individuals with inadequate sleep. Although we have previously shown that inflammatory genes are elevated in saliva samples taken from sleep deprived individuals, it is unclear if inflammatory genes will be elevated in clinical populations with EDS. In this study, salivary samples from individuals with sleep apnea were evaluated using the Taqman low density inflammation array. Transcript levels for 3 genes, including prostaglandin-endoperoxide synthase 2 (PTGS2) , were elevated in patients with sleep apnea. Interestingly, PTGS2 was also elevated in patients with EDS but who did not have sleep apnea. These data demonstrate the feasibility of using salivary transcript levels to identify individuals that self‐report excessive daytime sleepiness.
Transcriptional atlas of cardiogenesis maps congenital heart disease interactome (2014)

Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, knowledge of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candidate-gene approaches. Mapping the dynamic transcriptional landscape of cardiogenesis from a genomic perspective is essential to integrate the knowledge of heart development into translational applications that accelerate disease discovery efforts toward mechanistic-based treatment strategies. Herein, we designed a time-course transcriptome analysis to investigate the genome-wide dynamic expression landscape of innate murine cardiogenesis ranging from embryonic stem cells to adult cardiac structures. This comprehensive analysis generated temporal and spatial expression profiles, revealed stage-specific gene functions, and mapped the dynamic transcriptome of cardiogenesis to curated pathways. Reconciling known genetic underpinnings of CHD, we deconstructed a disease-centric dynamic interactome encoded within this cardiogenic atlas to identify stage-specific developmental disturbances clustered on regulation of epithelial-to-mesenchymal transition (EMT), BMP signaling, NF-AT signaling, TGFb-dependent EMT, and Notch signaling. Collectively, this cardiogenic transcriptional landscape defines the time-dependent expression of cardiac ontogeny and prioritizes regulatory networks at the interface between health and disease.
An Optimized CoMP Transmission for a Heterogeneous Network Using eICIC Approach (2015)

Heterogeneous network deployment is considered to be among the most promising approaches to meet the demand for increasing communication capacity. The concept is that of increasing the number of cells while reducing their size to provide different layers of coverage. This paper proposes a coordinated method to face the interlayer and intralayer interference caused by the overlapping of heterogeneous cells. The aim is to exploit the benefits of both enhanced intercell interference coordination (eICIC) and coordinated multipoint (CoMP) approaches and to limit, at the same time, their drawbacks by means of their optimized joint use. The idea devised here is to build an ad hoc CoMP system on top of a basic eICIC mechanism. Therefore, the analysis focuses on the dynamic selection of users and cells involved in CoMP operations, with the goal of minimizing the unfulfilled data rate requests (UDRRs). Due to the computational complexity of the optimal solution, we propose a heuristic procedure and validate its accuracy by providing a comparison with the optimal numerical solution. In particular, our results show that the proposed method outperforms other benchmark solutions in terms of UDRRs and signaling overhead.
Discrimination of orange beverage emulsions with different formulations using multivariate analysis (2010)

Orange beverage emulsion containing 222.0 g kg(-1) gum arabic, 2.4 g kg(-1) xanthan gum and 152.7 g kg(-1) orange oil was predicted to provide the desirable emulsion properties. The present study suggests that the concentration of gum arabic should be considered as a primary critical factor for the formulation of orange beverage emulsion. This study also indicated that the interaction effect between xanthan gum and orange oil showed the most significant (P < 0.05) effect among all interaction effects influencing all the physicochemical properties except for density.
Matching Segments of Images (1979)

This correspondence describes research in the development of symbolic registration techniques directed toward the comparison of pairs of images of the same scene to ultimately generate descriptions of the changes in the scene. Unlike most earlier work in image registration, all the matching and analysis will be performed at a symbolic level rather than a signal level. We have applied this registration procedure on several different types of scenes and the system appears to work well both on pairs of images which may be analyzed in part by signal based systems and those which cannot be so analyzed.
Effect of Degree of Unsaturation on NOx Formation in Partially Premixed Flames of Biofuels (2009)

The effect of iodine number on NOx formation in laminar flames of three oxygenated biofuels was studied at an equivalence ratio of 2. Neat soy methyl ester, neat canola methyl ester, and methyl stearate, which had similar energy content and carbon chain length, were tested. The iodine numbers for these fuels varied from 0.5 to 142. Inflame NOx concentration and temperature were measured. The peak NOx concentration occurred in the near-burner region for all biofuels: 404 ppm for soy, 388 ppm for canola, and 123 ppm for the methyl stearate fuel, and did not correlate with the location of the peak temperature. Therefore, the peak concentration in this region was traced to the Fenimore mechanism. Also, the peak NOx concentration was significantly increased with iodine numbers (degree of unsaturation of the fuel molecule). Thus, a strong correlation exists between the chemical structure of the fuel and the NOx emission of the premixed flame.
The ULb′ Region of the Human Cytomegalovirus Genome Confers an Increased Requirement for the Viral Protein Kinase UL97 (2013)

We report a requirement for the viral protein kinase UL97 in human cytomegalovirus (HCMV) replication that maps to the ULb' region of the viral genome. A UL97-null (Δ97) mutant of strain TB40/E, which encodes a full-length ULb' region, exhibited replication defects, particularly in production of cell-free virus, that were more severe than those seen with a Δ97 mutant of laboratory strain AD169, which harbors extensive deletions in its ULb' region. These differences were recapitulated with additional HCMV strains by treatment with a UL97 kinase inhibitor, 1-(β-L-ribofuranosyl)-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir). We observed lower levels of viral DNA synthesis and an increased requirement for UL97 in viral late gene expression in strains with full-length ULb' regions. Analysis of UL97-deficient TB40/E infections by electron microscopy revealed fewer C-capsids in nuclei, unusual viral particles in the cytoplasmic assembly compartment, and defective viral nuclear egress. Partial inhibition of viral DNA synthesis caused defects in production of cell-free virus that were up to ≈ 100-fold greater than those seen with cell-associated virus in strains TB40/E and TR, suggesting that UL97-dependent defects in cell-free virus production in strains with full-length ULb' regions were secondary to DNA synthesis defects. Accordingly, a chimeric virus in which the ULb' region of TB40/E was replaced with that of AD169 showed reduced effects of UL97 inhibition on viral DNA synthesis, late gene expression, and production of cell-free virus compared to parental TB40/E. Together, these results argue that the ULb' region encodes a factor(s) which invokes an increased requirement for UL97 during viral DNA synthesis.
Segmental Artery Injury Following Percutaneous Vertebroplasty Using Extrapedicular Approach (2011)

We performed a percutaneous vertebroplasty at the compressed L2 vertebral body of a 73-year-old female using a left-sided unilateral extrapedicular approach. She complained severe radiating pain and a tingling sensation in her left leg two hours after the vertebroplasty. Spinal computed tomographic scan showed a large retroperitoneal hematoma, and a subsequent spinal angiography revealed a left L2 segmental artery injury. Bleeding was successfully controlled by endovascular embolization. Recently, extrapedicular approaches have been attempted, allowing for the avoidance of facet and pedicle injury with only a unilateral approach. With this approach, however, the needle punctures the vertebral body directly. Therefore, this procedure carries the potential risk of a spinal segmental artery.
Gram-Negative Outer and Inner Membrane Models:  Insertion of Cyclic Cationic Lipopeptides (2006)

Most Gram-negative bacteria are susceptible to polymyxin B (PxB), and development of resistance to this cationic lipopeptide is very rare. PxB mechanism of action involves interaction with both the outer membrane (OM) and the inner membrane (IM) of bacteria. For the design of new antibiotics based on the structure of PxB and with improved therapeutic indexes, it is essential to establish the key features of PxB that are important for activity. We have used an approach based on mimicking the outer layers of the OM and the IM of Gram-negative bacteria using monolayers of lipopolysaccharide (LPS) or anionic 1-palmitoyl-2-oleoylglycero-sn-3-phosphoglycerol (POPG), respectively, and using a combination of penetration assay, analysis of pressure/area curves, and Brewster angle microscopy to monitor surface morphology changes. Synthetic analogue sp-B maintains the basic structural characteristics of the natural compound and interacts with the OM and the IM in a similar way. Analogue sp-C, with a mutation of the sequence [d-Phe6-Leu7] into [d-Phe6-Dab7], shows that this hydrophobic domain is involved in LPS binding. The significant role of the positive charges is demonstrated with sp-Dap analogue, where l-alpha,gamma-diaminobutyric acid residues Dab1 and Dab8 are replaced by l-alpha,gamma-diaminopropionic acid (Dap), resulting in lower degrees of insertion in both LPS and PG monolayers. The importance of the N-terminal acyl chain is demonstrated with polymyxin B nonapeptide (PxB-np). PxB-np shows lower affinity for LPS compared to PxB, sp-B, or sp-C, but it does not insert into PG monolayers, although it binds superficially to the anionic film. Since PxB microbial killing appears to be mediated by osmotic instability due to OM-IM phospholipid exchange, the ability of the different peptides to induce membrane-membrane lipid exchange has been studied by use of phospholipid unilamellar vesicles. Results indicate that cationic amphipathicity determines peptide activity.
The long and winding road to the structure of homo-DNA (2006)

Homo-DNA ((4'-->6')-linked oligo-2',3'-dideoxy-beta-D-glucopyranose nucleic acid) constitutes the earliest synthetic model system whose pairing properties have been studied within an etiology of nucleic acid structure. Its conception as part of a program directed at a rationalization of Nature's selection of pentoses over other candidates as the carbohydrate building block in the genetic material was motivated by the question: why pentose and not hexose? Homo-DNA forms an autonomous pairing system and its duplexes are entropically stabilized relative to DNA duplexes. Moreover, the base pairing priorities in homo-DNA duplexes differ from those in DNA. A deeper understanding of the particular properties of homo-DNA requires knowledge of its structure. Although diffraction data for crystals of a homo-DNA octamer duplex were available to medium resolution in the mid-1990s, it took another decade for the structure to be solved. In this tutorial Review we describe the odyssey from the crystallization to the final structure determination with its many failures and disappointments and the development of selenium chemistry to derivatize nucleic acids for crystallographic phasing. More than fifty years after the discovery of the DNA double helix, the story of homo-DNA also provides a demonstration of the limits of theoretical models and offers a fresh view of fundamental issues in regard to the natural nucleic acids, such as the origins of antiparallel pairing and helicality.
L'IMPIEGO DELLE STATINE NEL PAZIENTE EPATOPATICO CRONICO (2013)

Statins are drugs widely used worldwide to treat hypercholesterolemia reducing cardiovascular risk. Clinical guidelines of the Adult Treatment Panel III (ATP III) represent an updating of previous evidence-based recommendations, on the assessment of cholesterol effects, stressing the importance of the reduction of its plasma levels. The benefits resulting from the use of statins are not only related to lipid-lowering but also to its pleiotropic effects, such as anti-inflammatory action. Although, hepatotoxicity is a rare event (<2%), and often dose-related, in patients with liver disease fatal adverse effects have been reported using these molecules. The most important side effects consist of increased transaminase levels, abdominal pain, muscle weakness, increased levels of creatinekinase, up to rhabdomyolysis. The factors responsible for myopathy, during treatment with statins, may be related to the patient characteristics (age, female sex, alcoholism, hypothyroidism, systemic diseases, family history of myopathy, high consumption of grapefruit juice, large physical activity, major surgery, etc.) or to interaction with other medications (fibrates, cyclosporine, antifungals, macrolides, protease inhibitors, nefazodone, amiodarone, verapamil, etc.). Statins are inhibitors of HMG-CoA
Output feedback stabilization and restricted tracking for cascaded systems with bounded control (2004)

In this note we discuss the problems of output feedback stabilization for a class of cascaded systems and of (approximate) output regulation for general nonlinear systems. It is shown that (global) output feedback stabilization for a class of systems in feedforward form can be achieved with a dynamic feedback law, yielding bounded control, and relying on the introduction of a reduced order observer. The above result, together with standard tools borrowed from the nonlinear output regulator theory, is instrumental to construct dynamic control laws achieving (approximate) disturbance rejection and output tracking in the presence of (bounded) disturbance/reference signals generated by a known exosystem.
Specific binding to isolated acetylcholine receptor of a synthetic peptide duplicating the sequence of the presumed active center of a lethal toxin from snake venom. (1982)

To verify the existence of a lethal "active center" in snake venom neurotoxins and to assess its delineation within their polypeptide sequences, a tritriacontapeptide matching residues 16-48 of the natural "major" toxin of Naja naja philippinensis (Hauert, J., Maire, M., Sussmann, A., and Bargetzi, J. P. (1974) Int. J. Pept. Protein Research 6, 201-222) has been synthesized by solid-phase technology (Juillerat, M. A., and Bargetzi, J. P. (1980), results presented at the 16th European Peptide Symposium, Helsingor, Denmark, September, (1980). After deblocking, cyclization by reoxidation, and purification, one of the resulting peptides exhibiting the correct chemical and physical characteristics was found to be highly "active" in binding isolated, purified, and standardized acetylcholine receptor protein. A new assay procedure had been developed using 3H-labeled alpha-bungarotoxin as nonreversible back-titrant. It has the advantage of measuring only specific binding of an unknown ligand competing for the same receptor protein. The observed KD was 2.2 x 10(-7) M, a value attesting to a higher affinity than acetylcholine itself, 2.5 x 10(-6) M, as well as curare and the small organic cholinergic ligands, albeit somewhat lower than the affinity of the parent native toxin, as expected from differences in molecular size.
The Need for Improved Detection of Urinary Tract Infections in Young Children (2017)

Our findings support the need for improved communication and education about prevalence in higher risk populations, outcomes associated with delayed diagnosis, and optimal skills for collection of urine in young patients.
Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu's arteritis. (1994)

These results suggest that Takayasu's arteritis particularly clearly illustrates the occasional relationship between mycobacteria and diseases of superficially autoimmune pathogenesis.
Development of genetic markers for Ochradenus arabicus (Resedaceae), an endemic medicinal plant of Saudi Arabia (2012)

Some species of the genus Ochradenus are difficult to identify based on morphological markers. Similar limitations are found for biochemical markers. We developed genetic markers based on DNA sequences for Ochradenus arabicus, which is an endemic plant to Saudi Arabia, locally utilized as a medicinal shrub. The internal transcribed spacer sequence of nuclear ribosomal DNA and chloroplast (rpoB and rpoC1) markers were more informative than other chloroplast DNA markers. Based on these markers, we were able to discriminate this species from another species of the same genus (O. baccatus) that is widely distributed in Saudi Arabia, despite a high degree of morphological similarity. These genetic markers facilitate its identification, even when acquired in a dried state from local markets.
A Proposed Paradigm for Evaluating Spectrum Sharing Between a Cognitive Radar and 4G/5G Communications (2022)

Cognitive radar is an emerging technology in remote sensing. Standardized paradigms exist for testing, characterizing, and comparing traditional radar performance. No such standard has been set for cognitive spectrum sharing radar. We propose a set of metrics to evaluate not only the traditional radar performance, but also indicate the level of interference the cognitive radar imposes on the other spectrum users, namely 4G/L TE and 5G as well as other radar emitters. Three cognitive radar techniques are evaluated in four RFI environments using the proposed metrics paradigm. The radar performance results are compared to a traditional radar, and the interference results are compared to traditional interference metrics.
Proteomic characterization of human milk whey proteins during a twelve‐month lactation period (2011)

Human milk is a rich source of bioactive proteins that support early growth and development of the newborn. Although the major components of the protein fraction have been studied, the minor components have received limited attention. We examined the expression of low-abundance proteins in the whey fraction of human milk and their dynamic changes over a twelve-month lactation period. The low-abundance proteins were enriched by ProteoMiner beads, and protein identification was performed by liquid chromatography tandem mass spectrometry using a Paradigm MG4 HPLC system coupled with a Thermo LTQ ion trap spectrometer. X! Tandem software was set up to search the Uniprot human complete proteome set data base and Scaffold (Proteome Software) was used to validate MS/MS based peptide and protein identifications. One hundred and fifteen proteins were identified, thirty-eight of which have not been previously reported in human colostrum or milk. Eight functional groups were found: 35% of all proteins are involved in immune function, 17% in cell communication/signal transduction, 16% in metabolism/energy production pathways, 8% in protein metabolism (including translation, folding, trafficking, etc), 5% in cell growth and/or maintenance, 3% in nucleic acid metabolism and 3 % are multifunctional proteins. We also for the first time describe differences in protein patterns among the low-abundance proteins during lactation. These results enhance our knowledge about the complexity of the human milk proteome and provide suggestions for their physiological significance in the mammary gland and in the breast-fed infant. (Supported by Mead Johnson Nutrition)
Comparison between GnRH Antagonist and Agonist Long Protocols in Poor Responders (2010)

Ji Young Choi, Seung-Yup Ku1,2*, Hoon Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Jung Gu Kim, Shin Yong Moon Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Department of Obstetrics and Gynecology, Incheon Medical Center, Incheon, Korea
Tunable balanced bandpass filter with constant absolute bandwidth and high common mode suppression (2019)

A reconfigurable balanced bandpass filter with constant absolute bandwidth (ABW) and high common‐mode (CM) suppression by using the interdigital coupling compensation circuit structure is presented here. The odd‐ and even‐mode equivalent circuits of the presented balanced bandpass filter are presented and analysed. The differential mode and CM signals are misaligned by the half‐wavelength resonators, which are coupled by interdigital coupling circuit to improve the coupling coefficient and decrease the circuit dimension. Changing the voltage of the four varactors, which are placed at two ends of the half‐wavelength resonators with interdigital coupling circuits, can tune the coupling coefficient and resonant frequency at the same time. A tunable balanced bandpass filter with ABW is designed and realised. The measured results indicate that the differential‐mode tuning centre frequency range extends from 0.97 to 1.72 GHz, the 3 dB ABW is 80 ± 5 MHz, and the CM suppression is &gt;30 dB in the differential‐mode operating passband. Experimental results are in good agreement with the theoretical and simulated ones.
Is Perception of Handicap Related to Functional Performance in Persons with Vestibular Dysfunction? (2004)

Patients who perceive a greater handicap as a result of dizziness demonstrate greater functional impairment than patients who perceive less handicap from dizziness.
Supplementary Data from Pan-Cancer Efficacy of Vemurafenib in <i>BRAF</i><sup>V600</sup>-Mutant Non-Melanoma Cancers (2023)

&lt;p&gt;Supplementary figures 1 &amp; 2&lt;/p&gt;