gebhart/patrepeval huggingface dataset:
Evaluation of Twenty Human Adenoviral Types and One Infectivity-Enhanced Adenovirus for the Therapy of Soft Tissue Sarcoma (2007)

The clinical course of sarcoma warrants the development of new therapeutic options, such as gene therapy. However, the lack of coxsackievirus-adenovirus receptor (CAR) on sarcoma cells limits the efficacy of adenovirus type 5 (Ad5)-based gene therapy. In this study we evaluated 20 different adenoviral types and 1 Ad5 vector with RGD-containing fiber for their internalization efficiency in sarcoma cells. We demonstrated that adenovirus types 35, 3, 7, 11, 9, and 22 and Ad5lucRGD virions (ranked in descending order) have significantly higher internalization efficiency in the tested sarcoma cells when compared with Ad5. On the basis of these results we developed a conditionally replication-competent adenoviral vector, Ad5Delta24.Ki.COX, and compared its oncolytic efficacy with that of Ad5/35Delta24.Ki.COX, an Ad5-based vector with the Ad35 fiber shaft and knob domains. Because both vectors differed only in the fiber, we were able to assess whether the adenoviral type with the most efficient internalization resulted also in enhanced treatment efficacy. We evaluated the antineoplastic activity of the oncolytic adenoviral vectors alone or in combination with the expression of measles virus fusogenic membrane glycoproteins and/or ifosfamide. The findings of our xenograft model were as follows: animals that received Ad5/35-based therapy had significantly smaller tumors than animals treated with the homologous Ad5-based vectors. In addition, we demonstrated that the combination of virotherapy, intratumoral expression of fusogenic membrane glycoproteins, and ifosfamide was clearly superior compared with treatment with individual components alone or as combinations of two components. In conclusion, Ad35-based vectors are promising for the treatment of sarcoma.
Structural information in neuronal tissue as revealed byq-space diffusion NMR spectroscopy of metabolites in bovine optic nerve (1999)

1H NMR diffusion experiments performed on the signal of the metabolites in bovine optic nerve showed that the signal decay due to diffusion is bi-exponential with a slow and a fast diffusing component. Diffusion was measured as a function of the diffusion time, and the data were analyzed as a function of b and q values. Bi-exponential fit was used to analyze the data, and the results were compared with the displacement distribution profiles obtained from the q-space analysis of the data. This q-space analysis showed that the fast diffusing component has a broad displacement distribution and appears not to be restricted. On the other hand, the slow diffusing component appears to be highly restricted to milieu in the order of 1-2 microm. The orientation of the sample with respect to the axis for which diffusion was measured affected mainly the relative sizes of the populations of each component, but had only a small effect on the extracted apparent diffusion coefficients. These results from both the b and the q value analyses suggest that the slow diffusing component is related to restricted diffusion of these metabolites in the axonal fibers, while the fast diffusing component represents diffusion of metabolites in cells and along the long axis of the nerve fibers. It is concluded that q-space analysis of metabolite diffusion enables extraction of structural information about the sample, and that the diffusion of the metabolites in optic nerve is dictated mainly by the cellular medium and microstructure of the tissue.
"Status and Test Results of High Current 5-Cell SRF Cavities Developed at JLab" (2008)

The development of a new compact CW cryomodule for use in future Energy Recovery Linacs (ERLs) and Free Electron Lasers (FELs) is underway at JLab with the objective of transporting beam current up to Ampere-levels. Design goals include broadband cavity Higher Order Mode (HOM) damping, HOMs tuned to safe frequencies to minimize the power extracted from the beam, good real-estate gradient and cryogenic efficiency and consideration of cost and maintainability. Two 1497 MHz high current niobium five-cell cavities with waveguide end groups have been manufactured recently. We report on the latest results including high field tests in a vertical Dewar at 2K and a detailed assessment of the impedance budget for beam breakup (BBU) instability. The general cryomodule and cavity concept is described as well.
Examination on Measuring Methods of Pitting Potential of Stainless Steel and Its Application (1973)

To study the pitting behavior of austenite stainless steels, potentiostatic anodic polarization measurements were performed in NaCl solution at 35°C, varying the preparation of samples.Its results are as follows:1) Pitting potential free from crevice corrosion can be measured by the cathodic reduction method.2) After applying the cathodic reduction method to the materials which were investigated the effect of Ta addition to SUS316 because of improvement of the pitting corrosion resistance, the pitting potential has a maximum value at 0.05%Ta.3) The correlation between immersion pitting tests and anodic pitting tests is recognized, and the pitting potential measurement using the cathodic reduction method becomes a guide to predict the pitting behavior.
Optimizing stored light efficiency in vapor cells (2005)

We present a preliminary experimental study of slow and stored light in Rb vapor cells under the conditions of electromagnetically induced transparency (EIT). We study the efficiency of light storage as a function of pulse duration, storage time, retrieval field intensity, etc. We demonstrate that atomic diffusion in-and-out of the laser beam plays an important role not well described by previous analysis.
Supplementary Table S2 from Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma (2023)

&lt;p&gt;This table contains multivariable Cox Analyses on survival models in validation set&lt;/p&gt;
Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats (2011)

All findings suggest that the antifertility activity of extract could possibly be through the changes in the implantation site, altered hormonal levels, prolonged estrous cycle and anti-estrogenic activity. Hence, the extract possesses reversible antifertility activity without adverse toxicity in female rats.
Shiga toxin-associated hemolytic uremic syndrome: interleukin-1 beta enhancement of Shiga toxin cytotoxicity toward human vascular endothelial cells in vitro (1993)

Development of hemolytic uremic syndrome (HUS) after infection by Shigella dysenteriae 1 or enterohemorrhagic Escherichia coli has been associated with the production of Shiga toxins (verotoxins). The putative target of Shiga toxins in HUS is the renal microvascular endothelium. This report shows that preincubation of human umbilical vein endothelial cells (HUVEC) with interleukin-1 beta (IL-1 beta) enhances the cytotoxic potency of Shiga toxin toward HUVEC. A preincubation of HUVEC with IL-1 beta is required for sensitization of HUVEC to Shiga toxin. Sensitization of HUVEC to Shiga toxin is IL-1 beta dose dependent. Development of the IL-1 beta response is time dependent, beginning within 2 h of IL-1 beta preincubation and increasing over the next 24 h. That these responses were due to IL-1 beta was demonstrated by heat inactivation of IL-1 beta, by neutralization of IL-1 beta by specific antibody, and by the ability of an IL-1 beta receptor antagonist to inhibit the effect of IL-1 beta. Shiga toxin-related inhibition of HUVEC protein synthesis preceded loss of cell viability. IL-1 beta incubation with HUVEC induced the receptor for Shiga toxin, globotriaosylceramide. Lipopolysaccharide included during IL-1 beta preincubation with HUVEC increased sensitivity to Shiga toxin in an additive manner. We conclude that IL-1 beta may induce Shiga toxin sensitivity in endothelial cells and contribute to the development of HUS.
Cyber–Physical Control of Road Freight Transport (2016)

Freight transportation is of outmost importance in our society and is continuously increasing. At the same time, transporting goods on roads accounts for about 26% of the total energy consumption and 18% of all greenhouse gas emissions in the European Union. Despite the influence the transportation system has on our energy consumption and the environment, road transportation is mainly done by individual long-haulage trucks with no real-time coordination or global optimization. In this paper, we review how modern information and communication technology supports a cyber-physical transportation system architecture with an integrated logistic system coordinating fleets of trucks traveling together in vehicle platoons. From the reduced air drag, platooning trucks traveling close together can save about 10% of their fuel consumption. Utilizing road grade information and vehicle-to-vehicle communication, a safe and fuel-optimized cooperative look-ahead control strategy is implemented on top of the existing cruise controller. By optimizing the interaction between vehicles and platoons of vehicles, it is shown that significant improvements can be achieved. An integrated transport planning and vehicle routing in the fleet management system allows both small and large fleet owners to benefit from the collaboration. A realistic case study with 200 heavy-duty vehicles performing transportation tasks in Sweden is described. Simulations show overall fuel savings at more than 5% thanks to coordinated platoon planning. It is also illustrated how well the proposed cooperative look-ahead controller for heavy-duty vehicle platoons manages to optimize the velocity profiles of the vehicles over a hilly segment of the considered road network.
von Willebrand factor binding to collagen in patients with end-stage renal disease. (1994)

Bleeding abnormalities are common in patients with end-stage renal disease (ESRD). Although von Willebrand factor (vWF) abnormalities have been suspected in patients with ESRD, none have been clearly defined. Because vWF function is related to its collagen-binding capacity, we investigated whether this parameter might be altered in patients with ESRD. We measured vWF binding to type III collagen and levels of vWF antigen and ristocetin cofactor in 20 patients undergoing hemodialysis before and after routine hemodialysis sessions, in 10 patients with ESRD who had not previously undergone dialysis, and in 22 healthy, nonsmoking persons who served as controls. We found significant increases of vWF antigen levels in all patients with ESRD (undialyzed: mean, 6.4 +/- 3.0 U/ml, p < 0.001; before dialysis: mean, 5.1 +/- 4.0 U/ml, p < 0.001; after dialysis: mean, 4.8 +/- 3.4 U/ml, versus 0.81 +/- 0.26 U/ml in controls, p < 0.001). The ristocetin cofactor levels were increased in the patients who had not undergone dialysis (mean, 1.30 +/- 1.26 U/ml, p = 0.04), whereas both before and after hemodialysis groups (means, 0.71 U/ml and 0.75 U/ml, respectively) were not significantly different from controls (mean, 0.72 +/- 0.30 U/ml, p = 0.96 and p = 0.8, respectively). Patients with ESRD who had not undergone dialysis showed no difference in vWF binding to collagen (mean, 1.21 +/- 0.63 U/ml) compared with the control group (mean, 1.16 +/- 0.13).(ABSTRACT TRUNCATED AT 250 WORDS)
Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017–2018 Season (2020)

The trivalent seasonal influenza vaccine was the only approved and available vaccine during the 2016-2018 influenza seasons. It did not include the B/Yamagata strain. In this study, we report an acute respiratory disease outbreak associated with influenza B/Yamagata infections in Guangzhou, Southern China (January through March, 2018). Among the 9914 patients, 2241 (22.6%) were positive for the influenza B virus, with only 312 (3.1%) positive for the influenza A virus. The influenza B/Yamagata lineage dominated during this period in Southern China. The highest incidence of influenza A virus infection occurred in the children aged 5-14 years. In contrast, populations across all age groups were susceptible to the influenza B virus. Phylogenetic, mutations, and 3D structure analyses of hemagglutinin (HA) genes were performed to assess the vaccine-virus relatedness. The recommended A/H1N1 vaccine strain (A/Michigan/45/2015) during both 2017-2018 and 2018-2019 was antigen-specific for these circulating isolates (clade 6B.1) in Spring 2018. An outbreak of influenza B/Yamagata (clade 3) infections in 2018 occurred during the absence of the corresponding vaccine during 2016-2018. The recommended influenza B/Yamagata vaccine strain (B/Phuket/3073/2013) for the following season (2018-2019) was antigen-specific. Although there were only a few influenza B/Victoria infections in Spring 2018, five amino acid mutations were identified in the HA antigenic sites of the 19 B/Victoria isolates (clade 1A), when compared with the 2016-2018 B/Victoria vaccine strain. The number was larger than expected and suggested that the influenza B HA gene may be more variable than previously thought. One of the mutations (K180N) was noted to likely alter the epitope and to potentially affect the viral antigenicity. Seven mutations were also identified in the HA antigenic sites of 2018-2020 B/Victoria vaccine strain, of which some or all may reduce immunogenicity and the protective efficacy of the vaccine, perhaps leading to more outbreaks in subsequent seasons. The combined epidemiological, phylogenetic, mutations, and 3D structural analyses of the HA genes of influenza strains reported here contribute to the understanding and evaluation of how HA mutations affect vaccine efficacy, as well as to providing important data for screening and selecting more specific, appropriate, and effective influenza vaccine candidate strains.
Scaling Binarized Neural Networks on Reconfigurable Logic (2017)

Binarized neural networks (BNNs) are gaining interest in the deep learning community due to their significantly lower computational and memory cost. They are particularly well suited to reconfigurable logic devices, which contain an abundance of fine-grained compute resources and can result in smaller, lower power implementations, or conversely in higher classification rates. Towards this end, the Finn framework was recently proposed for building fast and flexible field programmable gate array (FPGA) accelerators for BNNs. Finn utilized a novel set of optimizations that enable efficient mapping of BNNs to hardware and implemented fully connected, non-padded convolutional and pooling layers, with per-layer compute resources being tailored to user-provided throughput requirements. However, FINN was not evaluated on larger topologies due to the size of the chosen FPGA, and exhibited decreased accuracy due to lack of padding. In this paper, we improve upon Finn to show how padding can be employed on BNNs while still maintaining a 1-bit datapath and high accuracy. Based on this technique, we demonstrate numerous experiments to illustrate flexibility and scalability of the approach. In particular, we show that a large BNN requiring 1.2 billion operations per frame running on an ADM-PCIE-8K5 platform can classify images at 12 kFPS with 671 us latency while drawing less than 41 W board power and classifying CIFAR-10 images at 88.7% accuracy. Our implementation of this network achieves 14.8 trillion operations per second. We believe this is the fastest classification rate reported to date on this benchmark at this level of accuracy.
Molecular markers and outcomes in penile squamous cancer (PSC). (2011)

e15016 Background: Penile cancer is uncommon but can be disfiguring and aggressive. We explored specific molecular changes in PSC and their relationship to outcomes. Methods: After IRB approval, 52 patients were identified from 1995 and 2010 with tissue specimens and clinical data available. ERCC1 and EGFR expression were evaluated by RT-PCR plus IHC for a subgroup; TS expression was by RT-PCR only. RNA results represent a ratio of the gene of interest to internal reference gene β-actin. Immunohistochemistry (IHC) was graded 0-2+ by an experienced pathologist. Results: Median age is 52 (36-80) and 72% are Hispanic, 15% white, 6.5% each Asian and African-American. 6 had stage Tis, 10 had T1, 23 had T2, 12 had T3; 19 had pathologic documentation of lymph node involvment. With a median follow-up of 1.8 years the (longest 16.3 yrs) median survival is 4.9 years. 17 men received neoadjuvant chemotherapy for >N2 disease or for distant metastases; 7 had disease progression on chemo, 8 (47%) had objective response including 1 pathologic CR. EGFR over-expression was common both by RNA amplification (median 5.09, range 1.92-104.5) and immunohistochemistry (IHC); 7/22 had 2+ staining. EGFR expression >7 correlated significantly with more advanced T stage and poor differentiation (p=0.01 and 0.034 by Fisher’s exact test, respectively); it did not correlate with survival or lymph node involvement in multivariate analysis. ERCC1 expression was less common, median RNA expression 0.65 and range 0.21-1.87 with only 4/22 2+ by IHC. TS expression was intermediate, median 1.88 (range 0.54-6.47). ERCC1 and TS expression were not associated with grade, stage or survival. There were no KRAS mutations identified. There was a trend for lower expression of EGFR corresponding to a higher likelihood of response (RR) to chemotherapy; 67% RR in EGFR<7 vs. 33% in EGFR>=7, p=0.31) and the trend was similar using IHC scores with no responses seen in thsoe wtih 2+ EGFR expression (p=0.16). Conclusions: We did not find a significant correlation between survival and EGFR, ERCC1, or TS expression in penile SCC. EGFR expression showed a trend for inverse relationship with chemotherapy response. The lack of KRAS mutation may predict a good likelihood of response to EGFR-targeted therapy.
Tuning the band-gap of h-boron nitride nanoplatelets by covalent grafting of imidazolium ionic liquids (2016)

Imidazolium ionic liquids having three different anions are covalently grafted on the h-boron nitride nanoplatelets to probe the shifts in the band gap energy.
Freeform Fabrication of Photonic Crystals with 3‐Dimensional Diamond Structure by Micro‐Stereolithography (2006)

This chapter contains sections titled: Intoduction Experimental Results and Discussion Conclusions
Single-center randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of acute myocardial rejection. (1998)

Tacrolimus was associated with similar efficacy and safety profiles compared with cyclosporine. The higher interpatient variance in absorption associated with oral tacrolimus during the first few days after transplantation would suggest that intravenous tacrolimus should be used during the perioperative period.
Design and development of electromagnetic absorbers with carbon fiber composites and matching dielectric layers (2001)

Radar absorbing materials are designed and developed with carbon fibers and suitable matching layers. Complex permittivities of carbon fiber composite are predicted on the basis that the modulus of permittivity obeys a logarithmic law of mixtures and the dielectric loss tangents are related through a linear law of mixtures. Linear regression analysis performed on the data points provides the constants which are used to predict the effective permittivities of carbon fiber composite at different frequencies. Using the free space measurement system, complex permittivities of the lossy dielectric at different frequencies are obtained. These complex permittivities are used to predict the reflectivity of a thin lossy dielectric layer on carbon fiber composite substrate. The predicted results agree quite well with the measured data. It is interesting to note that the thin lossy dielectric layer, about 0.03 mm thick, has helped to reduce the reflectivity of the 5.2 mm thick carbon fiber composite considerably.
Cytoarchitecture of Zika virus infection in human neuroblastoma and Aedes albopictus cell lines (2016)

The Zika virus (ZIKV) pandemic is a global concern due to its role in the development of congenital anomalies of the central nervous system. This mosquito-borne flavivirus alternates between mammalian and mosquito hosts, but information about the biogenesis of ZIKV is limited. Using a human neuroblastoma cell line (SK-N-SH) and an Aedes albopictus mosquito cell line (C6/36), we characterized ZIKV infection by immunofluorescence, transmission electron microscopy (TEM), and electron tomography (ET) to better understand infection in these disparate host cells. ZIKV replicated well in both cell lines, but infected SK-N-SH cells suffered a lytic crisis. Flaviviruses scavenge host cell membranes to serve as replication platforms and ZIKV showed the hallmarks of this process. Via TEM, we identified virus particles and 60-100nm spherular vesicles. ET revealed these vesicular replication compartments contain smaller 20-30nm spherular structures. Our studies indicate that SK-N-SH and C6/36 cells are relevant models for viral cytoarchitecture study.
New Technologies Used in the Construction of a Cable-Stayed Bridge: Binzhou Yellow River Bridge in the Shandong Province In China (2007)

The Binzhou cable-stayed bridge, with three pylons over, the Yellow River in Shandong province in China was constructed between the years 2001 and 2004. The total length of this bridge is 1698 m. The width of a standard section of superstructure is 32.8m, which is the widest PC box girder bridge in China. Several new technologies were used during construction. This paper introduces these technologies and experiences to present the state of the art of bridge construction in China and give reference to the bridge engineers. The deepest drilled pile reached 120 m, which is the deepest drilled pile in China. A drilled hole can be washed in 15 minutes using a new technology. The depth of precipitation is lower than 15 centimeter in a cleaned hole. The safety and condition of this bridge remains good in the two years after its construction. Abstract Introduction Erection of construction platform (new technology) Drilling Placing of the liquid concrete Conclusions References