gebhart/patrepeval huggingface dataset:
Characterization of Inducible Nitric-oxide Synthase by Cytochrome P-450 Substrates and Inhibitors (1997)

Nitric-oxide synthases (NOS, EC 1.14.13.39) are heme-containing enzymes that catalyze the formation of nitric oxide from L-Arg. General cytochrome P-450 inhibitors and cytochrome P-450 isoform-selective substrates and inhibitors were used to characterize the activity of recombinant human inducible NOS (iNOS). Classical cytochrome P-450 ligands such as the mechanism-based inactivator 1-aminobenzotriazole did not inhibit iNOS. Of a panel of 30 human cytochrome P-450 isoform-selective substrates and inhibitors, only chlorzoxazone, a cytochrome P-450 2E1 (CYP2E1) substrate, showed any significant inhibition of iNOS activity. Chlorzoxazone was not a substrate for iNOS but was a potent competitive inhibitor with respect to L-Arg with Ki = 3.3+/-0.7 microM. The binding of chlorzoxazone to iNOS and human and rat liver microsomal cytochrome P-450 induced a high spin, type I spectra, which was reversed by imidazole. Although the binding of chlorzoxazone to iNOS and its inhibition of iNOS activity suggest some similarity between iNOS and CYP2E1 activity, other CYP2E1 substrates and inhibitors including zoxazolamine were not inhibitors of iNOS. Overall, iNOS activity is distinctly different from the major cytochrome P-450 enzymes in human liver microsomes.
Hierarchical Self-Assembly of Responsive Organoplatinum(II) Metallacycle–TMV Complexes with Turn-On Fluorescence (2016)

Here we report that the rod-like tobacco mosaic virus (TMV), having a negatively charged surface, can be assembled into three-dimensional micrometer-sized bundle-like superstructures via multiple electrostatic interactions with a positively charged molecular "glue", namely, a tetraphenylethylene (TPE)-based discrete organoplatinum(II) metallacycle (TPE-Pt-MC). Due to the nanoconfinement effect in the resultant TMV/TPE-Pt-MC complexes and the aggregation-induced emission (AIE) activity of the TPE units, these hierarchical architectures result in a dramatic fluorescence enhancement that not only provides evidence for the formation of novel metal-organic biohybrid materials but also represents an alternative to turn-on fluorescence. Moreover, the dissociation of these final constructs and subsequent release of individual virus have been achieved by disrupting the TPE-Pt-MC core using tetrabutylammonium bromide (TBAB). This strategy is also compatible with other protein-based nanoparticles such as bacteriophage M13 and ferritin, proving the generality of this approach. Hence, this research will open new routes for the fabrication of functional biohybrid materials involving metal-organic complexes and anisotropically shaped bionanoparticles.
Nucleosomes and Anti‐Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus (2002)

Introduction Reactivity of Anti-Chromatin Antibodies with Glomerular Components The Nucleosomes as Mediator of Autoantibody Binding to the GBM Evidence for Nucleosome-Mediated Binding in Lupus Nephritis Conclusion References
Optimizing measurement when lymph nodes merge on serial CT in clinical trials. (2018)

e18590 Background: To investigate the size change of merging target lymph nodes (Merged LN), and to compare with Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 on these nodes. Methods: We retrospectively assessed size change of metastatic target lymph nodes (short axis diameter ≥ 1.5 cm) that merged on serial CT exams of chest, abdomen, and pelvis in 182 patients with various cancers. Short axis changes of three other well-circumscribed lymph nodes were recorded to represent Surrogate Lesions and their mean percentage change was considered as the ground truth. As only up to two nodes can be selected as Target Lesion in RECIST, two possibilities were considered: 1- One target node had merged with other nodes. 2- Two neighboring target nodes had merged. Then based on orientation of merging, we subdivided group 1 into 1-A: Linear and 1-B: Non-Linear RECIST was compared to the Surrogate and a mean correction factor was calculated in each group. Applied correction factor was considered as an alternative method. Results: We identified 20 cases with 1 merged target lesion and 9 with 2 merged target lesions. Mean percent size change of Surrogate Lesions in groups 1-A, 1-B, and 2 was +52, +44, +45 respectively, while RECIST showed +56, +118, -5. Mean size change in RECIST was similar to Surrogate in group 1-A, but a significant difference was noted between RECIST and Surrogates in groups 1-B (P < 0.001) and 2 (P < 0.001). While in all cases the Surrogates indicated an increase in size, in 77% of cases with 2 target lesions RECIST showed a decrease in size. Calculated Correction factor was 1, 0.75, 1.5 for groups 1-A, 1-B, and 2 resulted in mean size change of +56, +64, +42 respectively. Conclusions: Applying a correction factor of 0.75 when 1 target node Non-Linearly merges to the others and 1.5 when 2 target nodes merge, can improve RECIST measurement in clinical trials. Our proposed correction factors may improve RECIST assessments in clinical trials when 1 target lymph node non-linearly merge with other nodes, or 2 neighboring target nodes merge. Table 1: Mean % size change by RECIST 1.1, Surrogate Lesions and applied correction factor in Merged LN % Size Change Group 1-A Group 1-B Group 2 RECIST 1.1 +56 +118 -5 Surrogate Lesions +52 +44 +45 Applied Correction Factor +56 +64 +42
A Method for Recovering Fluorine as Sodium Silicofluoride (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Method for Recovering Fluorine as Sodium SilicofluorideSydney Atkin, Enrico Pelitti, Alan Vila, and John HegedusCite this: Ind. Eng. Chem. 1961, 53, 9, 705–707Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/ie50621a023https://doi.org/10.1021/ie50621a023research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Squeeze‐Casting and Thixo‐Casting of Magnesium Alloys (2003)

This chapter contains sections titled: Introduction Process Development Process Description Squeeze-Casting Thixo-Casting Literature
‘Mississippi Shipper’ Cowpea (1985)

Abstract ‘Mississippi Shipper’ is a new cowpea [ Vigna unguiculata (L.) Walp.] cultivar that maintains pod wall color during the time required for fresh market shipping, storage, and retailing. It was released in 1984 by the Mississippi Agricultural and Forestry Experiment Station to fill the need for a purple hull brown crowder type adapted to shipping, with multiple disease and insect resistance.
Asymmetric Synthesis of Stagonolide-D and Stagonolide-G (2011)

Abstract First asymmetric synthesis of the naturally occurring epoxy noneolide stagonolide-D has been reported in this article. Ring-closing metathesis (RCM) by Grubbs second generation catalyst, Sharpless asymmetric epoxidation (SAE), and cis-selective Horner–Wadsworth–Emmons (HWE) olefination by Ando method are the key reactions successfully employed to achieve the target molecule in a divergent approach. Structurally related small ring macrolide stagonolide-G has also been synthesized by employing RCM and a metal–enzyme combined dynamic kinetic resolution (DKR) strategy starting from (S)-ethyl lactate as a chiral pool.
Postauricular Response in Motor Paresis with Intracranial Lesions (1992)

The clinical usefulness of the postauricular response (PAR) in the evaluation of motor paresis was studied in 105 patients with intracranial lesions and 25 normal volunteers. Click stimuli at 90 dB hearing level were delivered in each ear, and PARs recorded from bilateral posterior auricular muscles with reference to the vertex (Cz). No volunteer demonstrated PAR in the relaxed posture, but in tensed postures increasing muscle tone PARs were elicited with a latency of 11.5 +/- 0.7 msec and an amplitude of 6.2 +/- 2.8 muV. Sixty-two patients (59%) had high-amplitude PARs in the relaxed posture. PARs were enhanced more frequently in paretic patients than in non-paretic patients (p less than 0.01). In subcortical lesions, the PAR latency had a significant correlation with the degree of motor paresis (p less than 0.005). In patients, the enhanced PAR amplitude suggested the presence of motor paresis associated with deep-seated mass lesions. The enhanced response is thought to be associated with dysfunction of the pyramidal and extrapyramidal tracts.
Human antibody response to the major adhesin of Mycoplasma pneumoniae: Increase in titers against synthetic peptides in patients with pneumonia (1991)

Peptides corresponding to parts of the P1 protein (major adhesin) of Mycoplasma pneumoniae were synthesized. On the basis of predicted antigenicity, seven sequences containing 17 to 21 amino acids were selected. In addition, one peptide containing a sequence of 13 amino acids shown to be related to cytadherence of M. pneumoniae was included. Serum samples from 56 patients with pneumonia were tested for a rise in titers of specific IgG during infection, using the peptides as coating antigens in ELISA. A titer rise against one or more peptides was observed in 10 out of 13 patients with serological evidence of mycoplasmal etiology. Specific antibodies to two or more peptides were demonstrated in three patients, whereas seven patients responded to one peptide only. In the sera from patients with pneumonia of non-mycoplasmal etiology, no titer rises above the cut-off level were observed. Our results indicate that a combination of four peptides would be possible for use as antigen for serological diagnosis of infections with M. pneumoniae.
Electric field stress determination tool for MV insulation system models (2020)

Abstract The evolution of teaching methods concerned with electrical engineering enables the development of new measurement stands or the improvement of existing educational methods. The advancement in engineering equipment is affecting the formation of new methodologies in teaching. Nevertheless, new educational techniques should be implemented by taking into account understanding of a physical basis of studied phenomena. This goal may be achieved via a combination of practical exercises conducted on testing stands, during evaluation, by means of modern computerized tools. In this paper, we described the combination of a numeric study of electric field (EF) distribution and an improved analog method analysis performed on an educational set‐up. For an effective understanding of technical problems of high‐voltage (HV) and medium‐voltage technology, the presented educational tool combines an experimental method of EF equipotential line mapping and EF strength determination with an improved analog method of EF strength inside the HV insulation system, which is determined by means of differential equation calculation implemented on the developed software. For fast verification of the results, computer simulations were applied. It allows for presenting the strong and weak points of both used methods. Analyzed models reproducing real devices were built on different scales; thus, achieved results reflect the real values and may be used for study help during seminars.
Supplementary Figures 1 - 4 from Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib (2023)

&lt;p&gt;PDF file - 1641K, Supplementary figure 1. Stereospecific targeting of PARP by BMN 673. Supplementary figure 2. Lack of effect of PARP inhibition on ATP concentration. Supplementary figure 3. Flow cytometry analyses after treatment with different PARP inhibitors. Supplementary figure 4. Stereospecific poisoning of PARP by BMN 673.&lt;/p&gt;
Posterior vitreous detachment: more a case of the fibronectin interface than the inner limiting membrane? (2015)

Purpose Use the periodic acid shift and immunohistochemical staining to visualize the distribution of the inner limiting membrane components on eyes presenting Posterior Vitreal Detachment ( PVD ) as detected by Optical Coherence Tomography ( OCT ) Methods Porcine eyes with PVD confirmed by OCT were processed into paraffin tissue blocks. Transverse, serial 15 mm thick sections were cut. After deparaffinization and antigen retrieval stages, slides were incubated with selected primary antibodies. Amplification stages were performed before fluorescence visualization of the specified marker. Among the markers stained were collagen II and IV , laminin beta 2 and fibronectin. Periodic acid shift staining was also performed on adjacent cross sections to assess potential structural change ( PVD ). Images were acquired on a Zeiss microscope and image analysis performed using Metamorph software (Leica). Results Different distribution patterns in the retina were observed for the selected markers. The inner retina blood vessels were labelled by laminin beta 2, collagen II and IV . Laminin beta 2 and collagen II was revealed on the Bruch membrane. Collagen II , IV , fibronectin and laminin beta 2 were detected at the inner limiting membrane. PVD area could be detected not only by periodic acid shift but also by fibronectin staining. Upon PVD , fibronectin staining completely migrated with the PVD front, cleanly detaching from the retinal cell layers. Conclusions Fibronectin staining can be used to detect and therefore confirm PVD presence in histological sections, even if the PVD has evolved beyond the point where it can still be detected by OCT .
Multi-View Multi-Label Learning With View-Label-Specific Features (2019)

In multi-view multi-label learning, each object is represented by multiple data views, and belongs to multiple class labels simultaneously. Generally, all the data views have a contribution to the multi-label learning task, but their contributions are different. Besides, for each data view, each class label is only associated with a subset data features, and different features have different contributions to each class label. In this paper, we propose a novel framework VLSF for multi-view multi-label learning, i.e., multi-view multi-label learning with View-Label-Specific Features. Specifically, we first learn a low dimensional label-specific data representation for each data view and construct a multi-label classification model based on it by exploiting label correlations and view consensus, and learn the contribution weight of each data view to multi-label learning task for all the class labels jointly. Then, the final prediction can be made by combing the prediction results of all the classifiers and the learned contribution weights. The extensive comparison experiments with the state-of-the-art approaches manifest the effectiveness of the proposed method VLSF.
Overexpression of Grb2-associated Binder 2 in Human Lung Cancer (2011)

Our data indicate that Gab2 is over-expressed in malignant lung tissues compared with that in normal lung tissues, and suggest that Gab2 expression may play a role in lung cancer development.
An evaluation of the clinical diagnostic value of contrast-enhanced ultrasound combined with contrast-enhanced computed tomography in space-occupying lesions of the kidney [Corrigendum] (2018)

[This corrects the article on p. 3493 in vol. 10, PMID: 28761358.].
Iron-Promoted C–C Bond Cleavage of 1,3-Diketones: A Route to 1,2-Diketones under Mild Reaction Conditions (2011)

A conceptual method for the preparation of 1,2-diketones is reported. The selective C-C bond cleavage of 1,3-diketones affords the 1,2-diketones in high yields under mild reaction conditions in air by the use of FeCl(3) as the catalyst and tert-butyl nitrite (TBN) as the oxidant without the use of solvent. The possible reaction mechanism is discussed. This protocol provides an expeditious route to the useful 1,2-diketones.
Dissecting the Functional Role of Polyketide Synthases in Dictyostelium discoideum (2008)

Dictyostelium discoideum exhibits the largest repository of polyketide synthase (PKS) proteins of all known genomes. However, the functional relevance of these proteins in the biology of this organism remains largely obscure. On the basis of computational, biochemical, and gene expression studies, we propose that the multifunctional Dictyostelium PKS (DiPKS) protein DiPKS1 could be involved in the biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol (MPBD). Our cell-free reconstitution studies of a novel acyl carrier protein Type III PKS didomain from DiPKS1 revealed a crucial role of protein-protein interactions in determining the final biosynthetic product. Whereas the Type III PKS domain by itself primarily produces acyl pyrones, the presence of the interacting acyl carrier protein domain modulates the catalytic activity to produce the alkyl resorcinol scaffold of MPBD. Furthermore, we have characterized an O-methyltransferase (OMT12) from Dictyostelium with the capability to modify this resorcinol ring to synthesize a variant of MPBD. We propose that such a modification in vivo could in fact provide subtle variations in biological function and specificity. In addition, we have performed systematic computational analysis of 45 multidomain PKSs, which revealed several unique features in DiPKS proteins. Our studies provide a new perspective in understanding mechanisms by which metabolic diversity could be generated by combining existing functional scaffolds.
A simple, effective synthesis of carborane nitriles (1996)

Lithium- and bromomagnesium-carboranes are readily converted into the nitriles by reaction with p-toluenesulfonyl cyanide.
A frequency offset booster with an oscillation prevention function for land mobile communication (1987)

The apparatus and experimental results of the FOB are described in this paper. The frequency offset booster (FOB) is a new reradiation system for mobile communications. Reradiation systems boost radio signals both from a cell sites and mobile stations in poor signal reception areas, using the same transmit frequency as the receive frequency. Because there is the danger of oscillation with re-radiation systems used in the open-air caused by spillover signals from the transmit antenna to receive antenna, their use in open-air areas is strongly restricted. The FOB can measure the amount of spillover signal, and maximizes the re-radiation gain with preventing oscillation. The FOB consists of a frequency converter, a spillover signal detector and a gain controller in addition to the fundamental components of a re-radiation system. It slightly offsets the transmission frequency from reception frequency. The spillover signal detector measures the offset frequency component in the received signal.
A Study on the Diesel Engine Mixed with Gaseous Fuel in the Intake Pipe. (1997)

The lean combustion limit of methane-air mixture around gasoil sprays in the direct injection diesel engine has been measured experimentally. The experimental results show if the equivalence ratio of the mixture which is formed in the intake pipe is greater than 0.034, the mixture burns and the output power which is 15 % of calorific value of supplied methane is produced. It is confirmed that the intensity of combustion luminance which measured by using of optical fiber thermometer decreases with increasing of supplying methane. The time histories of pressure and temperature in the cylinder have been calculated by the modified two zone model which is developed to apply for diesel fumigation system. The lean combustion limit of the mixture around gasoil sprays is estimated by thismodel.
Exploring fluorescence and fragmentation of ions produced by electrospray ionization in ultrahigh vacuum (2009)

Fluorescence spectroscopy and mass spectrometry have been extensively used for characterization of biomaterials, but usually separately. An instrument combining fluorescence spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry (FTICR-MS) has been developed to explore both fluorescence and mass spectrometric behavior of ions produced by electrospray ionization (ESI) in ultra high vacuum (<5 x 10(-9) mbar). Using rhodamine 6G (R6G) as a sample, the instrument was systematically characterized. Gas-phase fluorescence and mass spectral signal of the same ion population are detected immediately after each other. Effects of gas pressure, ion density, and excitation laser power on the fluorescence signal intensity and mass spectral fragmentation patterns are discussed. Characteristic times of ion photodissociation in ultra high vacuum were recorded for different irradiation powers. Photofragmentation patterns of rhodamine 6G ions in the Penning trap of an FTICR spectrometer obtained by photoinduced dissociation (PID) with visible light and sustained off-resonance irradiation collision-induced dissociation (SORI-CID) were compared. The lowest energy dissociation fragment of rhodamine 6G ions was identified by relating PID patterns of rhodamine 6G and rhodamine 575 dyes at various irradiation powers. The unique instrument provides a powerful platform for probing the intramolecular relaxation mechanisms of nonsolvated ions when interacting with light, which is of great fundamental interest for better understanding of their physical and chemical properties.
TI DSP implementation of a medium speed DSL (MDSL) for multimedia applications (2002)

The high performance general purpose digital signal processor (DSP) provides a cost efficient solution for a broadband digital subscriber line (DSL) transceiver. A DSL modem with a transmission throughput between 400 kbps and 2 MOPS operating over most of the existing telephone subscriber loops has been implemented on a single TI TMS320c548 DSP for consumer multimedia applications such as Internet access. Except the analog front end (AFE), all the discrete multitone modem (DMT) algorithms are implemented with DSP software. The DSP based software DSL modem also provides a convenient interface to Microsoft point-to-point protocol (PPP) for network access.
Ovine herpesvirus 1 (OVHV-1) thymidine kinase locus sequence analysis: evidence that OVHV-1 belongs to the Macavirus genus of the Gammaherpesvirinae subfamily (2014)

The HindIII-HincII fragment of the 5.5 kbp H11 HindIII clone of ovine herpesvirus 1 (OvHV-1) was cloned and its primary structure was determined by preparation of nested deletion subclones and their sequencing. Sequence analysis of the overlapping clones revealed that 3239 bp OvHV-1 fragment contains complete thymidine kinase (TK) gene, a partial open reading frame of ORF20 and that encoding glycoprotein H (gH). The conserved OvHV-1 TK displayed the highest similarity to homologous TK proteins encoded by members of the Macavirus genus of the Gammaherpesvirinae subfamily. These data including our previous analysis of the partial sequence of VP23 homologue might serve as further evidence that OvHV-1 should be categorized within the genus Macavirus of the Herpesviridae family.