gebhart/patrepeval huggingface dataset:
The version 4.1 of jMRUI : a state-of-the-art plug-in platform for medical MRS (2011)

The software package jMRUI (http://www.mrui.uab.es/mrui or http://fast-mrs.eu) with Java-based Graphical User Interface is being developed for user-friendly time-domain analysis of medical Magnetic Resonance Spectroscopy, Spectroscopic Imaging, and HRMASNMR signals. The beta version 4.0 has been distributed already to 1900 researchgroups and hospitals world-wide. The new version 4.1 resulting from the efforts of the European Marie Curie project FAST is an enhanced plug-in platform, offering new important functionalities.
Development of raphe serotonin neurons from specification to guidance (2011)

The main features of the development of the serotonin (5-HT) raphe neurons have been known for many years but more recent molecular studies, using mouse genetics, have since unveiled several intriguing aspects of the specification of the raphe serotonergic system. These studies indicated that, although all 5-HT neurons in the raphe follow the same general program for their specification, there are also clear regional differences in the way that these neurons are specified and are guided towards different brain targets. Here we overview recent progress made in the understanding of the developmental programming of serotonergic neurons in the mouse raphe, emphasizing data showing how heterogeneous subsets of 5-HT neurons may be generated. Serotonergic progenitors are produced in the brainstem in different rhombomeres under the influence of a set of secreted factors, sonic hedgehog and fibroblast growth factors, which determine their position in the neural tube. Two main transcriptional gene networks are involved in the specification of 5-HT identity, with Lmx1b and Pet1 transcription factors as main players. A differential requirement for Pet1 was, however, revealed, which underlies an anatomical and functional diversity. Transcriptional programs controlling 5-HT identity could also impact axon guidance mechanisms directing 5-HT neurons to their targets. Although no direct links have yet been established, a large set of molecular determinants have already been shown to be involved in the growth, axon guidance and targeting of 5-HT raphe neurons, particularly within the forebrain. Alterations in the molecular mechanisms involved in 5-HT development are likely to have significant roles in mood disease predisposition.
Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project (2016)

The mpMRI is an important tool for characterizing and targeting PCa in clinical practice and FT. Standardization of acquisition and reading should be the main priority to guarantee consistent mpMRI quality throughout the urological community.
Asymmetric Heck Reaction: Catalytic Asymmetric Syntheses of Bicyclic Enones, Dienones and the Key Intermediate for Vernolepin (1993)

Bicyclic enone 23a, a functionalized decalin derivative, has been synthesized in up to 86% ee by an asymmetric Heck reaction starting with bisallylic alcohol 24. Enone 23a has been converted to 19, a key intermediate in the synthesis of vernolepin (14). Furthermore, bicyclic dienone 43 has been synthesized in up to 83% ee from the prochiral dienone 39.
Effects of Wen‐Pi‐Tang and its crude drug extracts on proliferation of cultured mouse mesangial cells (1994)

Abstract The efficacy of Wen‐Pi‐Tang and each of its crude drug extracts on the proliferation of mouse mesangial cells was determined in terms of [ 3 H]thymidine uptake. When Wen‐Pi‐Tang was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells markedly. Similar to the effects of Wen‐Pi‐Tang, Rhei Rhizoma, its main ingredient, exerted an inhibitory effect on mesangial cell proliferation at a relatively low concentration. Ginseng Radix and Aconiti Tuber were also an effective crude drug. As for Zingiberis Rhizoma, an inhibitory activity at relatively high concentration was noted. However, the proliferation of mesangial cells in the presence of Glycyrrhizae Radix showed no particular alteration. As is clear from the results of the present study, Rhei Rhizoma, Ginseng Radix, Aconiti Tuber and Zingiberis Rhizoma alone each exert an inhibitory effect. The inhibition of mesangial cell proliferation by Wen‐Pi‐Tang can thus be explained by the action of these crude drugs.
Joint iterative channel estimation and decoding for bit-interleaved coded modulation over correlated fading channels (2005)

We design and evaluate a novel and highly efficient algorithm, named sparsely interleaved estimation and decoding (SIED), for joint iterative channel estimation and decoding for bit-interleaved coded modulation (BICM) over flat correlated fading channels. In SIED, in order to effectively prevent error propagation, the decoding proceeds until the current decoder stage converges, and only then feeds back the best achievable decoding results to refine channel estimates. The on-line convergence is detected through the soft decoding metrics (SDMs). Further, we provide a unified analytic framework for both the choice of filter length and an asymptotic bit error rate (BER) analysis, where the key parameter is the power correlation coefficient between the fading and its estimate. Simulation results verify that our SIED algorithm can successfully break the barrier of the channel estimation error caused by conventional pilot symbol-assisted modulation (PSAM), and lead the BER to approach the ideal asymptotic performance. Compared to the classical iteratively filtered PSAM (IF-PSAM) algorithm, our proposed SIED algorithm has more than 0.5-dB improvement in E/sub b//N/sub 0/ for the normalized fade rate f/sub d/T/sub s/=0.05 with much lower complexity.
Quality of life for adult leukemia survivors treated on clinical trials of cancer and leukemia group B during the period 1971-1988 (1997)

Patients experiencing anticipatory distress during treatment who are younger and less educated should be monitored for depressive syndromes later.
Dielectric and tunable properties of highly (110)-oriented (2009)

Highly (110)-oriented Ba0.65Sr0.35TiO3 films were deposited on Pt/LaNiO3/SiO2/Si substrates by a sol-gel method. It was found that the (110)-preferred Pt film was very effective for growing (110)-oriented ferro- electric films with perovskite structure. The as-grown Ba0.65Sr0.35TiO3 films showed good dielectric properties with dielectric constant e T =e0 ¼ 1750 and loss tangent tan d = 0.026. Excellent dielectric tunability was also achieved in the (110)-oriented films. With applying an electric field of 230 kV/cm at 100 kHz, the dielectric tunability and the figure of merit can reach up to 63.4% and 16, respectively. These results indicate that the highly (110)-oriented Ba0.65Sr0.35TiO3 film is a promising candi- date for the applications in microwave tunable devices.
Acetylcholinesterase Fiber-Optic Biosensor for Detection of Anticholinesterases (1991)

Acetylcholinesterase Fiber-Optic Biosensor for Detection of Anticholinesterases. Rogers, K. R., Cao, C. J., Valdes, J. J., Eldefrawi, A. T., and Eldefrawi, M. E. (1991). Fundam. Appl Toxicol16, 810–820. An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate (FITC)-tagged eel electric organ acetylcholinesterase (AChE) on quartz fibers and monitoring enzyme activity. The pH-dependent fluorescent signal generated by FITC-AChE, present in the evanescent zone on the fiber surface, was quenched by the protons produced during acetylcholine (ACh) hydrolysis. Analysis of the fluorescence response showed Michaelis–Menten kinetics with a Kapp value of 420 μm for ACh hydrolysis. The reversible inhibitor edrophonium (0.1 mm) inhibited AChE and consequently reduced fluorescence quenching. The biosensor response immediately recovered upon its removal. The carbamate neostigmine (0.1 mm) also inhibited the biosensor response but recovery was much slower. In the presence of ACh, the organophosphate (OP) diisopropylfluorophosphate (DFP) at 0.1 mm did not interfere with the ACh-dependent fluorescent signal quenching, but preexposure of the biosensor to DFP in absence of ACh inhibited totally and irreversibly the biosensor response. However, the DFP-treated AChE biosensor recovered fully after a 10-min perfusion with pralidoxime (2-PAM). Echothiophate, a quaternary ammonium OP, inhibited the ACh-induced fluorescence quenching in the presence of ACh and the phosphorylated biosensor was reactivated with 2-PAM. These effects reflected the mechanism of action of the inhibitors with AChE and the inhibition constants obtained were comparable to those from colorimetric methods. The biosensor detected concentrations of the carbamate insecticides bendiocarb and methomyl and the OPs echothiophate and paraoxon in the nanomolar to micromolar range. Malathion, parathion, and dicrotophos were not detected even at millimolar concentrations; however, longer exposure or prior modification of these compounds (i.e., to malaoxon, paraoxon) may increase the biosensor detection limits. This AChE biosensor is fast, sensitive, reusable, and relatively easy to operate. Since the instrument is portable and can be self-contained, it shows potential adaptability to field use.
P4747Impact of different estimates of renal function on cardiovascular mortality and major bleeding in patients with atrial fibrillation on oral anticoagulation (2019)

Abstract Background Renal dysfunction is associated with increased risk of cardiovascular events in atrial fibrillation (AF). Estimated glomerular filtration rate (eGFR) can be calculated by different equations based on creatinine or cystatin C. We compared different methods of assessing eGFR and their association with cardiovascular (CV) death and major bleeding in 14,980 AF patients in the ARISTOTLE trial. Methods eGFR was calculated using equations based on creatinine (Cockcroft-Gault, MDRD, and CKD-EPI) and/or cystatin C (CKD-EPIcys and CKD-EPIcys+crea). In total five eGFR equations as well as a model based on the variables within the equations were assessed. Associations were evaluated by Spearman correlation, and discriminatory ability for CV-death and major bleeding by Harrell's c-index. Results Median age was 70.0 years, and 35.6% were women. Median eGFR (mL/min) were: Cockcroft-Gault 74.1, MDRD 66.5, CKD-EPI 68.5, CKD-EPIcys 74.2, and CKD-EPIcys+crea 72.6. Correlation ranged from 0.49 (Cockroft-Gault and CKD-EPIcys) to 0.99 (MDRD and CKD-EPI). Among the eGFR equations, those based on cystatin C yielded the highest c-indices for CV-death and major bleeding, 0.628 (CKD-EPIcys) and 0.612 (CKD-EPIcys+crea), respectively. A model based on the variables within the eGFR equations (age, sex, weight, creatinine, and cystatin C) yielded the highest discriminatory value for both outcomes, 0.673 and 0.656, respectively. Figure 1 Conclusions In patients with AF on anticoagulation, correlation between eGFR methods varied greatly. Cystatin C-based eGFR seem to provide the most robust balance in reflecting the risk of death and bleeding. However, a model based on the individual variables within the eGFR equations provided the highest discriminatory value. Acknowledgement/Funding The ARISTOTLE trial was funded by Bristol-Myers Squibb, Co Princeton, NJ and Pfizer Inc., New York, NY.
History of structural analysis & dynamics of Wärtsilä medium speed engines (2018)

This paper opens up the history of structural analysis and dynamics simulations of Wärtsilä engines. It cites already published articles and theses with some backgrounds information. It also discusses some of the backgrounds of the in-house tool development. Additionally, this paper presents the development of the computers and investment of the simulation capacity in order to understand how it has been the enabler of ever more complicated models. It lists the work done during fifty decades. The authors sincerely attempt to make this article as reader-friendly as possible, even though there are over 220 references, which of course demonstrates how dedicated Wärtsilä has been in supporting numerical simulations research in the past fivedecades.
Practical parallel simulation applied to aviation modeling (2001)

This paper analyzes the Detailed Policy Assessment Tool (DPAT) as an example of a practical real-world aviation simulation that uses optimistic simulation technology. We present a review of analyses that have used DPAT results to support their conclusions, and discuss the design and performance of the system in the context of parallel simulation. The thrust of this paper is to explain how DPAT avoids some of the problems associated with optimistic simulation, while exploiting its strengths. A key conclusion is that parallel simulation technology, particularly optimistic synchronization, needs to be built into the product from its conceptual design through implementation, as opposed to adding it afterwards.
Hypertension and progression of renal disease. (2000)

That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several trials have compared the effects of different antihypertensive agents. The angiotensin-converting-enzyme inhibitors have the best renoprotective effect when compared to conventional agents and calcium channel blockers. In most studies, ACE-inhibitors approximately halved the risk of progressive renal functional deterioration in patients with non-diabetic nephropathies; this protection was associated with a significant reduction in systemic blood pressure and proteinuria. Statistical analysis, however, also suggests a direct effect of ACE-inhibitors on the kidney.
Multiview/stereoscopic video analysis, compression, and virtual viewpoint synthesis (1999)

Stereoscopic or in general multiview video can provide more vivid and accurate information about the scene structure than from monoview video. However one major obstacle for using multiview video is the extremely large amount of data associated with it. This dissertation considers the problem of structure and motion estimation in multiview tele-conferencing type sequences and its application for video sequence compression and for intermediate view generation. First, we describe a novel image alignment approach, which can convert images captured using non-parallel cameras to coplanar like images. This approach greatly eases the computational burden incurred by the non-parallel camera geometry, where one must consider both horizontal and vertical disparities. Next, we introduce a new approach for structure estimation from a stereo pair acquired by two parallel cameras. It is based on a 3D-mesh representation of the imaged object and a parameterization of the structure information by the disparity between corresponding nodes in the image pair. Finally we present a coder for multiview sequences, which exploits the proposed alignment and structure estimation algorithm. By extracting the foreground objects and estimating the disparity field between a selected view and a reference view, the coder can compress the image pair very efficiently. In the mean time, by using the coded structure information, the decoder can generate virtual viewpoints between decoded views, which can be very helpful for tele-presence applications.
Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus (2020)

Different parts of <i>Nuphar lutea L</i>. (yellow water lily) have been used to treat several inflammatory and pathogen-related diseases. It has shown that <i>Nuphar lutea</i> extracts (NUP) are active against various pathogens including bacteria, fungi, and leishmanial parasites. In an effort to detect novel therapeutic agents against negative-stranded RNA (- RNA) viruses, we have tested the effect of a partially-purified alkaloid mixture of Nuphar lutea leaves on the measles virus (MV). The MV vaccine's Edmonston strain was used to acutely or persistently infect cells. The levels of several MV proteins were detected by a Western blot and immunocytochemistry. Viral RNAs were quantitated by qRT-PCR. Virus infectivity was monitored by infecting African green monkey kidney VERO cells' monolayers. We showed that NUP protected cells from acute infection. Decreases in the MV P-, N-, and V-proteins were observed in persistently infected cells and the amount of infective virus released was reduced as compared to untreated cells. By examining viral RNAs, we suggest that NUP acts at the post-transcriptional level. We conclude, as a proof of concept, that NUP has anti-viral therapeutic activity against the MV. Future studies will determine the mechanism of action and the effect of NUP on other related viruses.
Research on Path Tracking Control for Vision Based Intelligent Vehicle (2011)

This paper proposes an optimal control method to achieve the path tracking mission for the vision based intelligent vehicle. After the access of road trajectory, path tracking task is achieved by the intelligent vehicle automatic steering devices. The angle deviation and lateral deviation relative to the target path can be controlled in the smaller range by state feedback optimal control. A car model contained road information is established for the achievement of intelligent vehicle path tracking and automatic steering. Some values of the variables needed for the control system are obtained by sensors mounted on the car, and achieve the path tracking by the optimal state feedback controller. The algorithm proposed has been validated by simulations. It can make the lateral deviation within the expected range stability. And also the lateral acceleration meets the ride comfort requirements.
Vision for high-availability of the global infrastructure (2002)

High availability is critical to the future of the information technology (IT) business. In many ways, it is fundamental to the future of the world economy as we become more reliant on the global infrastructure, Today it is not uncommon to witness losses exceeding /spl epsi/ per hour of outage in many segments of the industry. What is alarming is that there is no articulated vision on how high availability is to be achieved for end-to-end solutions running on the current global infrastructure. The goal of the Industrial Council is to develop a vision for high availability which can cut across many industries.
2499: Establishing a novel surgical model for optic nerve repair (2016)

BackgroundEfforts to transplant a mammalian eye have failed mainly due to the ganglion cell axon’s inability to withstand transection. Eye transplantation is not feasible without proof of optic ner...
Web-based data integration and annotation in the intensive care unit. (1997)

Integrating patient data to facilitate review and annotation is a challenging task in the intensive care unit (ICU), partially due to the wide variety of proprietary systems and types of data involved. This paper describes SIMON-Web, a Java-based user interface to integrate data from an existing bedside monitoring system and a clinical information system (CIS). SIMON-Web displays graphical data from physiologic monitors and other bedside devices as well as information from the clinical laboratory and physician order-entry systems, and allows users to annotate the data using a point-and-click or free-text interface. By continuing to add functionality to SIMON-Web's extensible user interface, we hope to continue to augment and eventually replace manual care provider data charting in the ICU. As of March, 1997, SIMON-Web has been implemented on two bedside personal computer workstations in the cardiac care unit (CCU) at Vanderbilt University Medical Center.
The use of Field Effect Transistors (FETs) in pharmacological research (2002)

In vitro studies have been extensively used in physiological and pharmacological research. Measurements of the effects of drugs on the heart are commonly performed using the isolated whole organ or electrophysiologically on cultured cardiac myocytes (CM). Over the past few years, FET arrays have been used as a tool for monitoring electrochemical signals from neuronal cultures. However, a quantitative use of the FET array as a tool for pharmacological measurements has not been fully validated. In this study we aim to demonstrate that FET arrays may be useful for future long-term pharmacological bioassays by showing that FET based systems can be used to detect the changes of myocyte responses in the presence of some well established cardioactive agents: isoproterenol (ISO), verapamil (VP) and carbamylcholine (CARB). In this study the rat CM cells were isolated from 8 to 10 embryonic Sprague Dawley rats (gestation d 15–18) and were plated at concentrations of 1–2 × 104cells per recording device. In our experiments a simple drug cycle regime was employed. Basal beat frequency in beats/min (bpm) of the cells on each device was recorded for 60 s prior to drug administration (Control, C). ISO (0.1 µm), VP (10 µm) or CARB (10 µm) was added and remained in contact with the cell layer for 60 s. The recording chambers were then washed 5 times with prewarmed fresh culture media, re-equilibrated for a further 5 min and then another 60 s control recording was taken to ensure complete recovery. All readings were taken at 33–35 °C. We found that ISO (a β-adrenoceptor agonist which stimulates G-proteins and enhances l-type calcium channel activity) caused significant increased in beat frequency (29 ± 3 bpm, n= 24, vs. 215 ± 6 bpm, n= 13, mean ± SD, P< 0.001) with no significant change in membrane Na+current. Although VP (a l-type calcium channel antagonist) did not cause a reduction in beat frequency, it completely diminished the Ca2+current and reduced the Na+current by 25% (n= 4). CARB (receptor-coupled, reduces cAMP, inhibits Ca2+current and opens K+channels) caused 95% reduction of beat frequency (214 ± 12 bpm, n= 7, vs. 11 ± 7 bpm, n= 7, P< 0.001). All statistical comparisons were made using a Student's unpaired t-test. This study clearly shows that FET systems can be used in the detection of responses of some well established agents. In our experiments we also found that one single culture could yield enough cells to prepare between 50 and 100 encapsulated devices with potentials to perform multichannels and multiFETs recordings simultaneously. Furthermore the FET system is sensitive enough to discriminate efficiently different ionic signatures. The experiment itself is straightforward and will be particularly advantageous when only a small quantity of drug is available or tissue availability is limited. More refinements are currently being considered in terms of the operating systems, FET fabrication and drug delivery. The current FET based bioassay system shows definite promise for drug testing on variety of cells in the near future.