gebhart/patrepeval huggingface dataset:
P2 receptor: Subclassification and structure‐activity relationships (1993)

Abstract Structure‐activity relationships (SAR) at P2 receptors that support their subclassification into at least five nucleotide receptor subtypes, P 2Z , P 2T , P 2Y , P 2U , and P 2X , are reviewed. The P 2Z receptor is the most sensitive to alterations to ATP. The adenine base, D‐ribose sugar, and 5′‐triphosphate chain are absolute requirements, but substitutions are tolerated at the C‐2 position and replacement by sulphur of an ionized phosphate oxygen leads to enhanced potency. The P 2T receptor, where ADP is the only endogenous agonist, has an absolute requirement for the adenine base, D‐ribose sugar, and a 5′‐diphosphate chain. C‐2 substitution and replacement by sulphur of an ionized oxygen is tolerated. Many analogs of AMP and of ATP are antagonists. The P 2Y receptor requires an adenine base, D‐ribose, and a 5′‐polyphosphate for maximal potency only. C‐2 substitution, and replacement of an ionized oxygen by sulphur, can enhance potency. Methylenephosphonate potencies depend on the position of the methylene group. ADP‐β‐F is a specific agonist. The P 2X receptor is least sensitive to alterations to ATP. There is no requirement for and adenine base, D‐ribose sugar, or triphosphate chain. Methylenephosphonates and some phosphorothioates have enhanced potencies. L‐AMP‐PCP is a specific agonist. Evidence from SAR for a P 2U subtype is reviewed. SAR studies are complicated by the presence of ectonucleotidases. The overall subclassification of P2 receptors is inadequate and awaits the availability of selective competitive antagonists. © 1993 Wiley‐Liss, Inc.
Pathogenic microbial amyloids: Their function and the host response. (2013)

Functional microbial amyloids are ubiquitous in nature and some contribute to the pathogenesis of infectious diseases. Three pathogenic microbial amyloids are compared and their contribution to the disease process explained. The recent demonstration and visualization of fungal amyloid in human invasive candidiasis is discussed. Moreover, the binding of host serum amyloid P component to <i>Candida</i> functional amyloid in invasive human disease is presented in light of its possible role of masking fungi from the host defenses.
Golden codes: quantum LDPC codes built from regular tessellations of hyperbolic 4-manifolds (2019)

30 pages, 4 figures
Synthetic Studies on the Cladiellins (Eunicellins): Unexpected Selenoxide Displacement with Concomitant Alcohol Oxidation During Attempted Selenoxide Elimination (2006)

In the course of studies directed towards the total synthesis of the marine diterpene natural product litophynin E, unexpected nucleophilic displacement of a selenoxide was observed upon ­oxidation of a selenide using MCPBA and heating the resulting ­selenoxide. An unusual fused tricyclic ketone was obtained as a crystalline solid in high yield and its structure was fully elucidated by X-ray crystallography.
Linear transform based motion compensated prediction for luminance intensity changes (2005)

A linear transform based motion compensated prediction (LT-MCP) scheme is proposed in this paper to improve the efficiency of inter-frame prediction when the intensity of luminance changes abruptly across frames. Either uniform or non-uniform intensity changes can be well processed as the proposed scheme is applied at macroblock (MB) level. LT-MCP is implemented based on the H.264 reference software to evaluate its performance. For those sequences with significant luminance changes across frames, such as Crew, we can achieve about 1.5dB improvement over the conventional MCP with intra prediction disabled and about 0.8dB gain with intra prediction enabled. For those sequences without obvious luminance changes, the proposed scheme also works better.
Methods for choosing the regularization parameter and estimating the noise variance in image restoration and their relation (1992)

The application of regularization to ill-conditioned problems necessitates the choice of a regularization parameter which trades fidelity to the data with smoothness of the solution. The value of the regularization parameter depends on the variance of the noise in the data. The problem of choosing the regularization parameter and estimating the noise variance in image restoration is examined. An error analysis based on an objective mean-square-error (MSE) criterion is used to motivate regularization. Two approaches for choosing the regularization parameter and estimating the noise variance are proposed. The proposed and existing methods are compared and their relationship to linear minimum-mean-square-error filtering is examined. Experiments are presented that verify the theoretical results.
Rapid Gas Chromatographic Assay of Serum Diazepam, N‐Desmethyldiazepam, and N‐Desalkylflurazepam (1977)

Abstract A rapid procedure for the measurement of serum diazepam (D), N‐desmethyldiazepam (ND), and N‐desalkylflurazepam (NF), levels in clinical samples is described. The single step extraction procedure yields quantitative extraction for the drugs mentioned above. No solvent evaporation step is needed. No interference of endogenous substances or generally used psychotropic drugs containing halogen atoms has been observed. The conditions provide excellent precision, due to a clear separation of the internal standard, medazepam, from the solvent front. The frequency response electron capture detector provides a linear response to the drugs over a 5 × 10 2 concentration range making serial dilution of the samples unnecessary. The automatic data reduction system indicates the serum levels directly in ng/ml without manual calculations.
VNMBench: A Benchmark for Virtual Network Mapping Algorithms (2012)

The network architecture of the current Internet cannot accommodate the deployment of novel network-layer protocols. To address this fundamental problem, network virtualization has been proposed, where a single physical infrastructure is shared among different virtual network slices. A key operational problem in network virtualization is the need to allocate physical node and link resources to virtual network requests. While several different virtual network mapping algorithms have been proposed in literature, it is difficult to compare their performance due to differences in the evaluation methods used. In this paper, we proposed VNMBench, a virtual network mapping benchmark that provides a set of standardized inputs and evaluation metrics. Using this benchmark, different algorithms can be evaluated and compared objectively. We present such an evaluation using three existing virtual network mapping algorithms. We compare the evaluation results of our synthetic benchmark with those of actual Emulab requests to show that VNMBench is sufficiently realistic. We believe this work provides an important foundation to quantitatively evaluating the performance of a critical component in the operation of virtual networks.
Construction and standardization of a bioreactor for the production of alkaline protease from Bacillus licheniformis (NCIM-2044) (2009)

Standardization of a Bioreactor for Industrial purpose is of prime importance. The construction of the Bioreactor needs a proper understanding of the different parts of the bioreactor and how they could be used. Hence the basic focus of this work was the Construction and the Standardization of the Bioreactor. The Production of Protease was done by altering the pH and checking the KL a level in the fermentation Process.
Ventricular remodeling in coronary artery disease (1997)

Analyzing 16 recent (1993 to 1997) references devoted to left ventricular aneurysm or wall motion abnormality after myocardial infarct, it appears that 1) cardiologists are on their way to detecting earlier the bad evolution of left ventricular geometry after myocardial infarct, 2) a great number of cardiac surgeons are using the technique of left ventricular reconstruction with circular reorganization of the left ventricular cavity, very often by endoventricular patch; and 3) this advance leads to a modification in the indications for surgery for left ventricular aneurysms or akinesia, either to prevent progressive dilatation, or to improve some apparently hopeless old and large akinesias.
Sequential Quadratic Method for GPS NLOS Positioning in Urban Canyon Environments (2013)

In this paper, the problem of GPS non-line-of-sight (NLOS) positioning in urban canyon environments is considered. We propose a new position-determination estimator based on sequential quadratic programming (SQP) that is able to estimate and eliminate the path-delay error caused by the indirect transmission of the GPS signal. The estimator takes into account the measurement bias resulting from NLOS transmission and also improves the location accuracy of the satellite positioning system. The present method can effectively eliminate NLOS delay errors and improves the location accuracy of a satellite navigation receiver in an urban canyon environment. A Wilcoxon-norm-based regressor is further derived to improve the probability of detection of NLOS biases. The Wilcoxon regressor is a robust estimator that is well-suited to identifying outliers (in our case, NLOS biases) during the regression process. Experimental results demonstrate that the proposed estimator can accurately compute a user’s location after identifying and removing the measurement biases.
Feather, Scent, and Shaker: Supporting Simple Intimacy (1996)

In this paper, we describe three experiments in designing for minimal, expressive communication. These are very simple networked devices that are aimed at supporting implicit, personal, and expressive communication, as opposed to the explicit, goal-oriented, and informative communication characterising most CSCW systems. We suggest that these prototypes open an interesting space for collaborative systems, and describe some of the issues and opportunities they raise.
A design for Controller Area Network bus real-time monitoring system (2011)

A net monitor system used to real-time monitor the state of the Controller Area Network (CAN) bus was designed. In the system, two while loops compose a producer consumer pattern which is the main program structure. The producer loop responds user actions and the consumer loop handles commands and data. The functions of the system such as data trace, graphics display, signal selection, and write frame are compiled in corresponding child VIs. Users can call those functions by clicking corresponding switches. While messages are transmitted in the bus, the signals that we want to monitor are real-time shown in the system. In the experiment, another CAN card is used to imitate the CAN bus that send messages to the monitoring system. The results show that the system can real-time monitor the CAN bus.
Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines. (2003)

Resistance to cisplatin is a major problem in the treatment of solid tumors. To investigate the determinants of cisplatin resistance, we have identified cisplatin-inducible genes by differential display of mRNA. One of the cisplatin-inducible genes was identified as activating transcription factor 4 (ATF4). Northern blot analysis demonstrated that expression of ATF4 is inducible at the transcriptional level. Its expression is also up-regulated in two cisplatin-resistant cell lines. We tested whether cellular levels of ATF4 are responsible for cisplatin sensitivity by examining 11 human lung cancer cell lines. Expression of ATF4 was found to correlate with cisplatin sensitivity (P = 0.01). We also evaluated the cisplatin sensitivity of two stable transfectants overexpressing ATF4. Both were less sensitive to cisplatin than the parental cells but equally sensitive to vincristine. Our findings suggest that levels of ATF4 expression could help to predict cisplatin sensitivity.
Multivalent bombesin analogues conjugated to DOTA-based chelators for targeted multimodal imaging of GRP-receptor positive tumors (2008)

Reference EPFL-CONF-160648View record in Web of Science Record created on 2010-11-30, modified on 2017-05-12
A Forensic Analysis Method for Redis Database based on RDB and AOF File (2014)

Redis is a widely used non-relational and in-memory database system. It holds a large amount of information both in memory and file system, which is of great significance to forensic analysis. This paper mainly proposes a forensic analysis method for Redis based on RDB and AOF file. A method of extracting useful information from RDB backup file is proposed based on the data storage mechanism described in this paper. A method of reconstructing the write operation statements from AOF file is also provided. Finally, the method of directly analyzing data from memory is shown. The experimental results demonstrate the effectiveness of our method. Most of the data could be extracted from RDB and AOF file, which provides important information for forensic investigators. Index Terms—Redis, NoSQL, database forensics, digital forensics
Elastic and electronic properties of select M2AX phases (2004)

In this letter we report on the low-temperature specific heat of several M2AX phases: Ti2AlC, V2AlC, V2AsC, Nb2SnC, Ti2AlN, Hf2InC, Nb2AlC, and Cr2AlC. The Debye temperatures are quite high. The density of states at the Fermi level, N(EF) varies from ≈1.4 (eV formula unit)−1 to 6 (eV formula unit)−1. Ab initio calculations show that N(EF) is dictated by the transition metal d–d bands; the A-group element has little effect. We also measured the velocity of sound in V2AlC, V2AsC, Ti2AlC, and Ti2AlN. The average bulk modulus of these materials is over 100 GPa, with a high of ≈140 GPa for Ti2AlN. Our theoretical calculations correctly predict the trend in both the density of states and the bulk modulus, although there is some disagreement in the actual values.
A connectionist approach for automatic speaker identification (2002)

A connectionist approach to automatic speaker identification based on the learning vector quantization (VQ) algorithm is presented. For each adherent to the identification system, a number of references is fixed. The algorithm is based on a nearest-neighbor principle, with adaptation through learning. The identification is realized by comparing to a given threshold the distance of the unknown utterance to the nearest reference. Preliminary tests run on a ten-speaker set show an identification rate of 97% for MFC coefficients. The identification system and database used and the results obtained for different combinations of parameters are given. The system is evaluated by comparing its performances with a Bayesian system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Morpheeins – A New Pathway For Allosteric Drug Discovery~!2010-02-12~!2010-05-21~!2010-06-08~! (2010)

The morpheein model of allosteric regulation can be applied as a novel approach to the discovery of small molecule allosteric modulators of protein function. Morpheeins are homo-oligomeric proteins where, under physiological conditions, the oligomer can dissociate, the dissociated units can change conformation, and the altered conformational state can reassociate to a structurally and functionally distinct oligomer. This phenomenon serves as a basis for allostery, as a basis for conformational diseases, as a basis for drug discovery, and may be applicable to personalized medicine such as in the prediction of drug side effects. Each of these relationships has been established for the prototype morpheein, porphobilinogen synthase, where the conformational disease is a porphyria and the drug application is in antimicrobial discovery. These data are presented along with a discussion of other drug targets for which the morpheein model of allostery may apply. Such targets include HIV integrase, TNFα, β-tryptase, and p53.
The cGMP-specific Phosphodiesterase Inhibitor E4021 Dilates the Pulmonary Circulation (1999)

We investigated the pulmonary vascular effects of E4021, a potent inhibitor of cGMP-specific phosphodiesterase, in control late-gestation fetal lambs, and in newborn lambs with persistent pulmonary hypertension (PPHN) after prenatal ligation of the ductus arteriosus. E4021 alone significantly relaxed fifth-generation pulmonary arteries isolated from control fetal lambs, an effect completely blocked after inhibition of nitric oxide synthase (NOS). In contrast, E4021 did not relax pulmonary arteries isolated from hypertensive lambs. Pretreatment with E4021 (10(-7) M) significantly enhanced relaxations to the NO donor S-nitrosyl-acetyl-penicilamine (SNAP) in arteries from both control and hypertensive lambs. In control, fully instrumented fetal lambs, infusions of E4021 (31 microgram/min) selectively dilated the pulmonary circulation, an effect again blocked after inhibition of NO synthase. Further studies were performed in newborn lambs with PPHN to study the vascular effects of E4021 alone, and in combination with inhaled NO. E4021 alone (1 to 100 microgram/kg/min) decreased pulmonary artery pressure (Ppa) in a dose-dependent fashion, and had minimal effect on systemic pressure. At the highest dose (100 microgram/kg/min), the dilation was selective for the pulmonary circulation. In subsequent protocols, E4021 (10 microgram/kg/min) significantly decreased Ppa and pulmonary vascular resistance (PVR), but these pulmonary vascular effects were not enhanced after NO inhalation at 0.5 or 5 ppm. We speculate that the lack of enhancement was due to the dramatic effects of E4021 alone. Potent, specific phosphodiesterase inhibitors such as E4021 may prove to be useful in the treatment of PPHN.
Platelet‐Rich Plasma Augmentation in Meniscal Repair Surgery: A Systematic Review of Comparative Studies (2020)

Level III, systematic review of Level I to III studies.
Common pine (Pinus sylvestris L.) survival abilitty and seedlings growth after treatment with low-frequency electromagnetic field (2021)

The results of studies carried out in the Pravdinsky nursery of the Pushkin Forestry Technical Colledge in the Moscow Region and in the laboratory of the department «Forest cultures, selection and dendrology» at the ВMSTU (Mytishchi branch) since May 2015 untill September 2019 are presented. The results of the study confirmed the significant advantage of experimental indicators over the control. Thus, the treatment of seeds and two-year-old seedlings of Scots pine with a low-frequency electromagnetic field using the POSEP technology, in general had a positive effect not only on their survival rate and biometric parameters, but also on their anatomical structure. Based on the results of the studies, it can be ststed that the POSEP technology is an effective method of physical impact on the survival rate and growth increase of Scots pine seedlings.
The complete mitochondrial genome of a deep-water Baikalian amphipoda Brachyuropus grewingkii (Dybowsky, 1874) (2015)

In this study, we present a complete mitochondrial genome of a deep-water amphipoda Brachyuropus grewingkii (Dybowsky, 1874) from Lake Baikal. A circular mitochondrial DNA has 17,118 bp in length and contains 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, a putative control region, and five intergenic spacers. An extended control region and altered positions of some tRNA genes distinguish mitochondrial genome of B. grewingkii from the mitochondrial genomes described for other Baikalian amphipoda species.
Involvement of protein kinase C in the mitogenic and chemotaxis effects of basic fibroblast growth factor on bovine cerebral cortex capillary endothelial cells (1990)

Basic fibroblast growth factor is increasingly implicated in cellular growth, differentiation, angiogenesis and oncogenesis. In culture, basic fibroblast growth factor greatly improved the growth rate of bovine brain cortex capillary endothelial cells. Down-regulation of protein kinase C by prolonged treatment with phorbol esters prevented the mitogenic effect of basic fibroblast growth factor on capillary endothelial cells. Furthermore, staurosporine, a potent protein kinase inhibitor, showed strong antiproliferative activity against basic fibroblast growth factor-induced endothelial cell growth. Similarly, the chemotaxis effect of basic fibroblast growth factor on capillary endothelial cells was abolished by down-regulation of protein kinase C or by staurosporine treatment. Therefore, it is suggested that protein kinase C could account for part of the angiogenic effect of basic fibroblast growth factor.
Internet anycast (2018)

Internet anycast depends on inter-domain routing to direct clients to their "closest" sites. Using data collected from a root DNS server for over a year (400M+ queries/day from 100+ sites), we characterize the load balancing and latency performance of global anycast. Our analysis shows that site loads are often unbalanced, and that most queries travel longer than necessary, many by over 5000 km.
Correlation of high-resolution computed tomography temporal bone findings with intra-operative findings in patients with cholesteatoma (2015)

Aim: To evaluate the role of high-resolution computed tomography (HRCT) temporal bone in patients with active squamosal chronic otitis media (COM). Materials and Methods: Totally, 47 patients with active squamosal COM underwent preoperative HRCT temporal bone followed by surgery. Their intra-operative findings were considered as the gold standard and were compared and correlated with the radiological findings, to calculate the sensitivity, specificity, positive and negative predictive value of HRCT temporal bone. Results: According to the present study, HRCT was highly sensitive for detecting mastoid pneumatization, soft tissue extension, ossicular erosion, tegmen and sigmoid sinus erosion, and less sensitive for fallopian canal erosion and lateral sinus fistula. It was specific for all these parameters. Conclusion: The present study concludes that HRCT can be recommended not only in cases suspected with potential complications but also in all cases of COM to know the extent of disease, varied pneumatization, and the presence of anatomical variations, which should alert the clinician and guide in surgical approach and treatment plan.
High Temperature Ion Conducting Ceramics (2001)

Research in materials today has progressed from materials exhibiting structural functionality to those exhibiting electronic functionality. The study of solid-state ionics ushers in a new era of chemically functional materials. This chemical functionality arises out of the defect equilibria of these materials, and results in the ability to transport chemical species and actively participate in chemical reactions at their surface.