gebhart/patrepeval huggingface dataset:
Real time monitoring of cytotoxicity in selection of agents for treatment of refractory malignancy (2006)

B47 Real time monitoring of the cytotoxic effects of cancer chemotherapeutic agents offers an attractive alternative to conventional end-point analyses in the selection of agent combinations for treatment of refractory malignancies. Personalized oncology treatment can be critical, since the genetic instability and continuous evolution of progressive malignant neoplasms, including many common cancers and AIDS-associated lymphomas, presents a major chemotherapeutic challenge. While the cellular mechanisms of therapeutic resistance are manifold, evolution of molecular changes that impair terminal differentiation or subvert apoptosis pathways frequently are implicated. One rational counterstrategy is to induce fatal checkpoint conflicts during the process of cell division cycling. In particular, malignant cells with p53 malfunction can become susceptible to S phase perturbation by relatively low concentrations of metabolic inhibitors or cytotoxic agents that would normally evoke a protective block in G1/ S phase transit. Accordingly, we have been analyzing effects of classical DNA metabolic or polymerase inhibitors, platinum coordination compounds, and indolocarbazole protein kinase inhibitors (K252a or staurosporine homologs) which can produce significant cytotoxic synergies using minimal agent concentrations. When DNA inhibition is just sufficient to slow the passage of malignant cells through S phase (dynamic retardation), dysregulation of the G2 or M phase transits by a complementary agent can be facilitated. We compared a real time method of kinetic optical response (KOR) to conventional end-point methods of flow cytometry, MTT assay, caspase cleavages, or stress kinase activation as a preclinical means to quantify apoptosis and optimize dosage. Continuous KOR spectrophotometry (24-48 hours) in 96-well cultures of malignant cells, generated unique parabolic graphs with slope shifts reflecting changes in cellular shapes and concomitant growth inhibition or apoptosis in response to the individual test agents or combinations. Preliminary results with established and primary ovarian cancer cells indicated that a KOR assay could offer practical guidance in agent selection and individualization of chemotherapies.
Mechanisms Regulating Lactation and Infant Nutrient Utilization (1991)

Research frontiers regarding the formation and composition of human milk, its health effects and the effects of lactation on the woman and child were explored by 32 scientists at The Fifth International Conference of The International Society for Research on Human Milk and Lactation.
Control of RF Sputtered Film Properties Through Substrate Tuning (1970)

A means has been found to control the rf potential of the substrate during rf sputtering. The application of this technique to the deposition of silica films has been investigated in detail. The technique can be described as the use of an adjustable rf impedance between the substrate holder and ground electrodes, which generates an rf potential by virtue of the flow of rf current through it. Adjustment of the rf potential of the substrate results in a controlled dc bias potential developed at the film surface, which correlates directly with the physical properties of the deposited films. In general, the most desirable film properties are obtained when the dc substrate bias (obtained by adjusting the substrate-holder rf impedance) is at a high negative potential. The effect of substrate bias on etch rate, pinhole breakup thickness, and argon content has been measured.
Microfracture treatment of single or multiple articular cartilage defects of the knee: a 5‐year median follow‐up of 110 patients (2009)

Abstract We compared the results of microfracture in single versus multiple symptomatic articular cartilage defects in the knee in 110 patients with a median age of 38 years (range 15–60). Cases of reoperation of the cartilage defect were classified as failures. Clinical outcome in non‐failures was evaluated by the Lysholm score and grading of knee pain and function of the knee by the use of patient‐administered visual analog scales (VAS; 0–100). Data were prospectively collected before the operation and at the 2‐ to 9‐year follow‐up. The single lesion or the largest of multiple lesions were located on the medial femoral condyle ( n = 62), trochlea ( n = 18), lateral tibia ( n = 11), patella ( n = 10) or lateral femoral condyle ( n = 9). We treated one ( n = 76), two ( n = 27) or three ( n = 7) lesions with a median total area of 4 cm 2 (range 1–15). A total of 24 failures (22%) were registered—18% in the single‐defect subgroup and 29% in the multiple‐defects subgroup. In the remaining group of patients ( n = 86), the mean Lysholm score, mean pain‐score (0 = no pain; 100 = worst possible pain) and mean function‐score (0 = useless; 100 = full function) improved from 51, 52 and 41, respectively, to 71 ( P &lt; 0.001), 30 ( P &lt; 0.001) and 69 ( P &lt; 0.001) at the follow‐up. The pain‐score was significant lower ( P = 0.042), and the function‐score significantly higher ( P = 0.001) in the group of patients with a single lesion compared to the group with 2 or 3 lesions. The Lysholm score did not differ significantly between the two subgroups ( P = 0.06).
The effects of added glycerol or unprotected free fatty acids or a combination of the two on silage intake, milk production, rumen fermentation and diet digestibility in cows given grass silage based diets (1997)

The addition of glycerol or free fatty acids either alone or in combination to concentrate was studied for the effects on feed intake, milk production, rumen fermentation, blood metabolites and diet digestibility in dairy cows given grass silage ad libitum. The study was conducted on 12 mid-lactating cows, four of them ruminally cannulated. Barley-based concentrate (control diet, C) was given 7 kg/d as fed. In the other three diets, 36 g/kg of barley was replaced by glycerol (G) or a mixture of free fatty acids (FA) or by a combination of the two, making a total of 72 g/kg (GFA). The experimental design consisted of balanced 4 x 4 Latin squares with a 2 x 2 factorial arrangement of diets: the effects of G, FA and G*FA interaction. The FA diets significantly decreased silage intake, increased milk yield, decreased milk protein content, increased the concentrations of C18:0, C18:1, and C20:1 and decreased those of C8-16, and C18:3 fatty acids in milk fat. The FA diets also increased the concentration of nonesterified fatty acids in plasma, and decreased the digestibility of organic matter and neutral detergent fibre but increased that of fat. Glycerol decreased the molar proportion of acetate and increased the molar proportions of propionate and butyrate in the rumen, but the addition of glycerol did not have any effect on silage intake, milk yield or milk composition. Milk yield was highest when glycerol and free fatty acids were given together, showing a positive interaction.
Laryngeal Muscle Surface Receptors Identified using Random Phage Library (2005)

Abstract Objectives: The ultimate goal of this study is to improve the efficiency of gene transfer in mammalian muscle by developing targeted adenoviral vectors. Altering the tropism of viral vectors to recognize tissue specific antigens is one method to achieve this goal. This approach requires identification of cell‐surface receptors and the insertion of target peptide sequences into the adenoviral fiber protein. In this study, phage biopanning was performed on cultured rat skeletal and laryngeal muscle to identify cell‐surface receptors. Study Design: In vitro cell culture and in vivo animal model. Methods: M‐13 Phage biopanning was used for muscle cell‐surface receptor analysis on cultured rat skeletal and laryngeal muscle. Nonbinding and binding phage to cultured skeletal and laryngeal muscle were screened for muscle specific surface peptides. In vivo studies were then performed using muscle specific phage. Results: Skeletal muscle specific binding by the YASTNPM phage was observed by in vivo immunostaining. Phage titering demonstrated a 10 9 ‐fold increase in skeletal muscle binding compared with nontarget tissue. A peptide sequence (NPSQVKH) specific for laryngeal muscle yielded a 10 7 ‐fold increase in laryngeal muscle phage titer compared with nontarget tissue. Conclusions: These results identify muscle cell‐surface receptors that may be used as potential targets for genetic modification of adenovirus tropism. Moreover, phage specificity for skeletal and laryngeal muscle indicates specific muscle groups may be targeted.
Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma (2015)

The purpose of this study was to assess the safety and efficacy of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma. Patients with multiple myeloma who had relapsed after at least one prior treatment were eligible to participate. In the dose escalation part of the study a standard 3+3 design was used to determine the maximum tolerated dose of four planned dose levels of the combination of carfilzomib and panobinostat. Panobinostat was administered on days 1, 3, 5, 15, 17, and 19. Carfilzomib was administered on days 1, 2, 8, 9, 15, and 16 of each 28-day cycle. Treatment was continued until progression or intolerable toxicity. Forty-four patients were accrued into the trial, 13 in the phase I part and 31 in the phase II part of the study. The median age of the patients was 66 years and the median number of prior therapies was five. The expansion dose was established as 30 mg panobinostat, 20/45 mg/m(2) carfilzomib. The overall response rate was 67% for all patients, 67% for patients refractory to prior proteasome inhibitor treatment and 75% for patients refractory to prior immune modulating drug treatment. At a median follow up of 17 months, median progression-free survival was 7.7 months, median time to progression was 7.7 months, and median overall survival had not been reached. The regimen was well tolerated, although there were several panobinostat dose reductions. In conclusion, the combination of panobinostat and carfilzomib is feasible and effective in patients with relapsed/refractory multiple myeloma. (Trial registered at ClinicalTrials.gov: NCT01496118).
Salt effect on the 9,10-dicyanoanthracene-sensitized photooxygenation of 1,2-diarylcyclopropanes and the photodecomposition of 3,5-diaryl-1,2-dioxolanes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSalt effect on the 9,10-dicyanoanthracene-sensitized photooxygenation of 1,2-diarylcyclopropanes and the photodecomposition of 3,5-diaryl-1,2-dioxolanesToshiyuki Tamai, Kazuhiko Mizuno, Isao Hashida, and Yoshio OtsujiCite this: J. Org. Chem. 1992, 57, 20, 5338–5342Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/jo00046a014https://doi.org/10.1021/jo00046a014research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effect of bending on the efficiency of the Yb LMA-fiber laser (2011)

A large mode area double-clad Yb-doped fiber is studied. The lasing characteristics are obtained for various experimental schemes, and the effect of bending of the active fiber on the laser efficiency is analyzed. The experimental data are compared with the results of theoretical calculations.
Tethering: Fragment‐Based Drug Discovery by Mass Spectrometry (2007)

This chapter contains sections titled: Introduction Reduction to Practice Technique Advantages Finding Fragments: Thymidylate Synthase Proof of Principle Finding and Linking Fragments in One Step: Tethering with Extenders Caspase-3 Caspase-1 Conclusions
An Update on Thalassemia Intermedia (2014)

Thalassemia intermedia is a genetically diverse group of diseases that is the result of an imbalance in the production of the alpha and beta chains with ensuing chronic hemolysis, ineffective erythropoiesis, and iron overload. Resulting complications include bone changes, hypercoagulability, and end-organ damage due to iron overload. This decade has witnessed major breakthroughs in the management of thalassemia. In this article, we examine these novelties in therapy including iron chelation therapy, stem cell transplant, and gene therapy. Iron chelation therapy has been revolutionized with the advent of deferasirox, a once-daily oral iron chelator, that has been shown to be safe and efficacious. Gene therapy was also at the core of this revolution with the discovery of novel gene elements and viral vectors allowing for better control and improved outcomes.
Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study (2008)

This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.
Anisotropic electronic properties of a-axis-oriented Sr2IrO4 epitaxial thin-films (2013)

We have investigated the transport and optical properties along the c-axis of a-axis-oriented Sr2IrO4 epitaxial thin-films grown on LaSrGaO4 (100) substrates. The c-axis resistivity is approximately one order of magnitude larger than that of the ab-plane. Optical absorption spectra with E//b polarization show both Ir 5d intersite transitions and charge-transfer transitions (O 2p to Ir 5d), while E//c spectra show only the latter. The structural anisotropy created by biaxial strain in a-axis-oriented thin-films also changes the electronic structure and gap energy. These a-axis-oriented, epitaxial thin-films provide a powerful tool to investigate the highly anisotropic electronic properties of Sr2IrO4.
Role of Oxygen Mass Transport in Rechargeable Li/O2 Batteries Operating with Ionic Liquids (2013)

The use of ionic liquid (IL)-based electrolytes and porous carbonaceous cathodes is today one of the most promising strategies for the development of rechargeable Li/O2 batteries. Enhancing Li/O2 battery cyclability at high discharge rate is a key issue for automotive applications. O2 reduction at a meso-macroporous carbon electrode in N-butyl-N-methyl pyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI):LiTFSI 9:1 is here investigated. The study demonstrates that oxygen electrode response in IL at high discharge currents is dominated by O2 mass transport in IL. A novel configuration of flow-Li/O2 battery that operates at high discharge rate is reported.
Magneto-Optical Disk By Contact Printing Method (1989)

this method. a highly reliable glass substrate can be obtained, however, there is aproblem of low productivity. It takes more than 30 minutes for patterning by a lasercutting machine. This paper describes a contact printing method which can improve theproductivity of conventional patterning, and discusses the signal performance of magneto -optical disks using a substrate prepared by this new method.
Shape-memory coaxial bimorphs (2009)

The thermal shape recovery shown by shape memory alloys is a property that makes these materials very attractive for applications in the field of smart structures, e.g. bending actuators. This article shows a design method for coaxial bimorphs that are composed of a linear-elastic and shape memory alloy component, properly coupled. A simple and effective method is proposed to solve for the component designs in order to achieve given bimorph configurations. Analytical examples and finite-element simulations are shown for the case of assigned bimorph's warm shape.
Nanostructured Nonadhesive Surfaces for Micro- and Nanomanipulation (2012)

Adhesion between microgripper end-effector and a nano/micro-object is a main topic for manipulation in micro- and nanoscale. Tuning this force is a great challenge. Adhesion force is directly linked to the chemical composition and the surface roughness of both, the object and the gripper. Recently, we proposed a multispheres van der Waals force model able to predict this force. The surface used was structured by an array of polystyrene spheres with radii from 35 nm to 2 μm. The experimental pull-off forces have confirmed our model. In this present work, we analyzed other innovating structure such as nonclosed packed polystyrene (PS) spheres and organized Si nanostructures, formed by chemical etching. The adhesion values of the pull-off force measured on these structures were very low (in the range of 2–10 nN) and suggest that these new structures have nonadhesive properties. A new model taking in account the roughness and the organization of the PS spheres and Si nanostructures has been developed to predict these new properties.
An Expert System Controlling an Adaptable Distributed Data Base System (1987)

The task of concurrency control is to synchronize the user transactions on this data base and with this to avoid conflicts that lead to faulty or inconsistent data.Concurrency control has been subject to active research for quite some time and several concurrency control algorithms have been proposed and implemented.The relative performance of these methods varies depending on the system environment (work load, user performance, reliability requirements etc.).No method showed a superior performance in all or a majority of applications.A adaptable concurrency control mechanism is needed that provides the optimal behavior in terms of response time and throughput in all or at least many possible applications.This mechanism is able to change the concurrency control algorithm depending on the system environment.The target of the research that is described in this paper is the selection of the concurrency control algorithm that is most suitable for achieving a high performance in the given system environment.An expert system is proposed for this function that operates on-line, real-time and without human assistance.A prototype software has been implemented in PROLOG.
PHMin Healthcare (2018)

This chapter introduces the trend of healthcare in the United States, and discusses unique features of healthcare devices and specific safety priorities, as well as clinical priorities related to the devices. It describes benefits of prognostics and health management (PHM) and summarizes the need for PHM in the healthcare devices. The chapter discusses considerations of healthcare devices - such as implantable devices and care bots - with the explanation of unique features of the devices. Unlike engineering venues where PHM is used on installed equipment or complex electronic systems, with implantable medical devices, data collection often occurs where “in situ” is consistent with “surgically embedded inside a patient”. The use of fuses and canaries for PHM presents unanswered questions. Enhanced PHM capabilities will allow detection of failures, avoid catastrophic failures, and prevent damage within the human body as well as for the medical devices.
Free Radical Scavenging Behavior of Antioxidant Compounds of Sesame (Sesamum indicum L.) in DPPH• System (2004)

The free radical scavenging capacity (RSC) of antioxidants from sesame cake extract was studied using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(*)()) on a kinetic model. Pure lignans and lignan glycosides isolated from methanolic extract by preparative HPLC were used in the study. To understand the kinetic behavior better and to determine the RSC of sesame antioxidants, the second-order rate constant (k(2)) was calculated for the quenching reaction with [DPPH(*)] radical. The k(2) values of the sesame antioxidants were compared with those of butylated hydroxytoluene and alpha-tocopherol. The k(2) values for sesamol, sesamol dimer, sesamin, sesamolin, sesaminol triglucoside, and sesaminol diglucoside were 4.00 x 10(-)(5), 0.50 x 10(-)(5), 0.36 x 10(-)(5), 0.13 x 10(-)(5), 0.33 x 10(-)(5), and 0.08 x 10(-)(5) microM(-)(1) s(-)(1), respectively.
An Experimental Investigation on the Combustion Process of a Simulated Turbocharged Spark Ignition Natural Gas Engine Operated on Stoichiometric Mixture (2017)

This research investigated the combustion process of an AVL Model LEF/Volvo 5312 single cylinder engine configured to simulate the operation of a heavy-duty spark ignition (SI) natural gas (NG) engine operated on stoichiometric mixture. The factors affecting the combustion process that were examined include intake pressure, spark timing (ST), and the addition of diluents including nitrogen (N2) and carbon dioxide (CO2) to the NG to simulate low British thermal unit (BTU) gases. The mixing of diluents with NG is able to slow down the flame propagation speed, suppress the onset of knock, and allow the engine to operate on higher boost pressure for higher power output. The addition of CO2 was more effective than N2 in suppressing the onset of knock and slowing down the flame propagation speed due to its high heat capacity. Boosting intake pressure significantly increased the heat release rate (HRR) evaluated on J/°CA basis which represents the rate of mass of fuel burning. However, its impact on the normalized HRR evaluated on %/°CA basis, representing the flame propagation rate, was relatively mild. Boosting the intake pressure from 1.0 to 1.8 bar without adding diluents increased the peak HRR to 1.96 times of that observed at 1.0 bar. The increase was due to the burning of more fuel (about 1.8 times), and the 12.9% increase in the normalized HRR. The latter was due to the shortened combustion duration from 23.6 to 18.2 °CA, a 22.9% reduction. The presence of 40% CO2 or N2 in their mixture with NG increased the peak cylinder pressure (PCP) limited brake mean effective pressure (BMEP) from 17.2 to about 20.2 bar. The combustion process of a turbocharged SI NG engine can be approximated by referring to the HRR measured under a naturally aspirated condition. This makes it convenient for researchers to numerically simulate the combustion process and the onset of knock of turbocharged SI NG engines using combustion process data measured under naturally aspirated conditions as a reference.
Breast Reconstruction with Perforator Flaps (2007)

Perforator flaps allow for safe, reliable tissue transfer from a variety of sites and provide ideal tissue for breast reconstruction, with minimal donor-site morbidity.
GENE PRODUCTS OF BARLEY CHROMOSOMES 4 AND 7 ARE PRECURSORS OF THE MAJOR ANTIGENIC BEER PROTEIN (1984)

Proteins in grains of wheat-barley chromosome addition lines and in a protein-enriched concentrate from beer (Fraction X) were compared by tandem crossed immunoelectrophoresis. Two major beer proteins, called Antigen 1a and 1b, were found to be products of distinct structural genes positioned on barley chromosomes 4 and 7, respectively.