gebhart/patrepeval huggingface dataset:
The genes for the trophoblast interferons and the related interferon-alpha II possess distinct 5‘-promoter and 3‘-flanking sequences. (1991)

The genes for trophoblast interferons (IFN) bovine trophoblast protein-1 (bTP-1) and ovine trophoblast protein-1 (oTP-1) are expressed massively in the trophectoderm of preimplantation bovine and ovine concepti during the period of maternal recognition of pregnancy. These 172-amino acid IFN are closely related to the IFN-alpha II, a family of "long" IFN expressed in virus-induced leukocytes. Genomic Southern blotting with a full-length bTP-1 cDNA revealed about 15 genes that bind the probe with varying intensities. By using more specific probes for the 3'-ends of the cDNA, we have shown that only four to five of these represent bTP-1 genes, whereas no more than another four are IFN-alpha II. Genes for bTP-1 and IFN-alpha II, all of which are intronless, have been isolated from bovine genomic libraries, and their nucleotide sequences were compared. Additional bTP-1 genes and two distinct oTP-1 genes have been isolated from bovine and ovine genomic DNA by using the polymerase chain reaction procedure in conjunction with specific 3'- and 5'- primers (derived from the bTP-1 gene sequences determined above). The promoter region up to 100 bases upstream from the transcription start sites of the trophoblast IFN are almost completely conserved across different genes and across species, yet show only limited sequence identity with IFN-alpha II. Two putative binding regions for interferon regulatory factor-1 as well as several GAAANN motifs (where N is any nucleotide) that have been implicated in viral responsiveness of alpha 1- and beta-IFN genes are retained at identical positions in all of the trophoblast genes. Putative interferon regulatory factor-1-binding nucleotide hexamers and GAAANN motifs are also present in the IFN-alpha II genes, but these are organized very differently than in the trophoblast IFN genes. A GAAATG motif is present in IFN-alpha II promoters but is absent in trophoblast IFN genes. Based on the evidence presented, it is proposed that the trophoblast interferons constitute a separate subclass of IFN-alpha distinct from IFN-alpha II and IFN-alpha I.
Genetically Determined Low‐Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage (2021)

We evaluated whether genetically elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with lower risk of intracranial aneurysms and subarachnoid hemorrhage (IA/SAH). We conducted a 2-sample Mendelian randomization (MR) study. Our primary analysis used the inverse-variance weighted method. In secondary analyses, we implemented the MR-PRESSO method, restricted our analysis to LDL-C-specific instruments, and performed multivariate MR. A 1-mmol/l increase in genetically instrumented LDL-C levels was associated with a 17% lower risk of IA/SAH (odds ratio = 0.83, 95% confidence interval = 0.73-0.94, p = 0.004). Results remained consistent in secondary and multivariate analyses (all p < 0.05). Our results provide evidence for an inverse causal relationship between LDL-C levels and risk of IA/SAH. ANN NEUROL 2022;91:145-149.
Hierarchical multistage interconnection network R-Clos (2006)

This paper proposes the multistage interconnection network (MIN) R-Clos, with a hierarchical structure in which locality of communications can be utilized. In R-Clos, a Clos network, which is a three-stage MIN, is used as the local network. By interconnecting multiple Clos networks through the intermediate stage of the hierarchical structure, a large-scale system can be constructed with a smaller hardware requirement than that for a Clos network. On the other hand, due to the use of the Clos network, with great transfer power, as the network for nearby data communications, low latency and wide bandwidth can be provided for nearby access. The latency and throughput of the proposed configuration are evaluated by a simulation using a stochastic model. Although the performance is lowered for traffic with a uniform access pattern, the transfer performance is improved for a data distribution with high locality, compared to the recursive (2s−1)-stage Clos. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 89(11): 30–39, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.20280
Supplementary Table legend from CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival (2023)

&lt;p&gt;Supplementary Table legend. Supplementary Table legends S1, S2&lt;/p&gt;
Plume Characterization of an Ion-Focusing Hall Thruster (2012)

The T-220HT is a 10-kW class Hall effect thruster developed as the primary propulsion system for satellites. In-channel electrodes and additional magnetic coils are added to study ion focusing to decrease energy losses from ion-wall neutralization and plume divergence in order to increase the thrust-to-power ratio. In this study, electrically-biased graphite electrode rings are embedded in the discharge channel walls to repel radial ions. The thruster is tested from 125-300 V at 9 A discharge, with the electrodes either floating, biased to 10 V or 30 V. The mass flow rate was varied from 9.8-10.4 mg/s to maintain constant current. Maximum chamber pressure was 1.5e-5 Torr-Xe. Performance measurements on xenon show a maximum increase in thrust-to-power ratio of 4.84 mN/kW, 15.3 mN thrust, 206 s Isp, and 8% anode efficiency. The plume ion current density, ion energy distribution function, and plasma potential is characterized and indicates a collimation of the ion beam and a increase in ion number density without an increase in propellant neutrals, which results in an increase in mass utilization. The different electrode currents and ion energy distribution functions at 10 V compared to 30 V electrodes leads to the idea of different modes of operation with different electrode biases.
HER pathway gene expression analysis in a phase II study of pertuzumab + gemcitabine vs. gemcitabine + placebo in patients with platinum-resistant epithelial ovarian cancer (2008)

5552 Background: Pertuzumab (P) is a humanized monoclonal antibody that inhibits HER2 heterodimerization. A randomized phase II trial (N=130) of pertuzumab + gemcitabine vs. gemcitabine + placebo in patients with platinum-resistant (CDDP-R) epithelial ovarian cancer (EOC) suggested that pertuzumab could prolong PFS (HR 0.66, 95% CI 0.43, 1.03) and that the duration of PFS may be associated with HER3 gene expression. Final data for overall survival from this trial are presented. Methods: Patients with CDDP-R EOC were randomized to G+P or G+placebo. Treatment was given until progression or until unacceptable toxicity. The primary endpoint was PFS. A secondary objective was to evaluate efficacy outcomes in patients with HER2 activation-related expression profiles. A qRT-PCR assay using archival formalin-fixed paraffin-embedded tissue (FFPET) allowed mRNA expression analysis of HER pathway genes, including HER1, HER2, HER3, amphiregulin, and betacellulin. Outcomes were described by low gene expression (<median) and by high gene expression (>median). Results: Of the 5 biomarkers tested, only HER3 gene expression suggested a patient subgroup with a differential PFS and OS outcome based upon low vs. high results. Final PFS and OS outcomes for all patients and by qRT-PCR HER3 outcomes are as follows in the table below. Conclusions: This exploratory analysis suggests that low tumor HER3 gene expression levels may be prognostic in patients with CDDP-R EOC. Pertuzumab treatment may add to gemcitabine's clinical activity in patients whose tumors have low HER3 gene expression. These data suggest that HER3 mRNA expression levels may be a potential prognostic and predictive diagnostic biomarker. G + P G + Placebo Hazard Ratio (95% CI) PFS (median months) All Patients (n=130) 2.9 2.6 0.66* (0.43, 1.03) Low HER3 (N=61) 5.3 1.4 0.34 (0.18, 0.63) High HER3 (N=61) 2.8 5.5 1.48 (0.83, 2.63) OS (median months) All Patients (n=130) 13.0 13.1 0.91* (0.58, 1.41) Low HER3 (N=61) 11.8 8,4 0.62 (0.35, 1.11) High HER3 (N=61) 16.1 18.2 1.59 (0.8, 3.2) * All-patient analyses were stratified by ECOG status, disease measurability and # prior regimens for CDDP-R disease. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Genentech, Inc., Roche Diagnostics Genentech, Inc. Genentech, Inc. Genentech, Inc.
Epitaxy Induced Highly Ordered Sm2Co17–SmCo5 Nanoscale Thin-Film Magnets (2021)

Utilizing the molecular beam epitaxy technique, a nanoscale thin-film magnet of <i>c</i>-axis-oriented Sm<sub>2</sub>Co<sub>17</sub> and SmCo<sub>5</sub> phases is stabilized. While typically in the prototype Sm(Co, Fe, Cu, Zr)<sub>7.5-8</sub> pinning-type magnets, an ordered nanocomposite is formed by complex thermal treatments, here, a one-step approach to induce controlled phase separation in a binary Sm-Co system is shown. A detailed analysis of the extended X-ray absorption fine structure confirmed the coexistence of Sm<sub>2</sub>Co<sub>17</sub> and SmCo<sub>5</sub> phases with 65% Sm<sub>2</sub>Co<sub>17</sub> and 35% SmCo<sub>5</sub>. The SmCo<sub>5</sub> phase is stabilized directly on an Al<sub>2</sub>O<sub>3</sub> substrate up to a thickness of 4 nm followed by a matrix of Sm<sub>2</sub>Co<sub>17</sub> intermixed with SmCo<sub>5</sub>. This structural transition takes place through coherent atomic layers, as revealed by scanning transmission electron microscopy. Highly crystalline growth of well-aligned Sm<sub>2</sub>Co<sub>17</sub> and SmCo<sub>5</sub> phases with coherent interfaces result in strong exchange interaction, leading to enhanced magnetization and magnetic coupling. The arrangement of Sm<sub>2</sub>Co<sub>17</sub> and SmCo<sub>5</sub> phases at the nanoscale is reflected in the observed magnetocrystalline anisotropy and coercivity. As next-generation permanent magnets require designing of materials at an atomic level, this work enhances our understanding of self-assembling and functioning of nanophased magnets and contributes to establishing new concepts to engineer the microstructure for beyond state-of-the-art magnets.
Beschallung von Spritzgießdüsen (1979)

Die Ergebnisse der Modelluntersuchungen ließen ein weiteres Absinken der Ultraschalleffektivität im realen Spritzgießprozeß erwarten, da hier die auftretenden Strömungsgeschwindigkeiten wesentlich größer sind.
Detection of single infrared, optical, and ultraviolet photons using superconducting transition edge sensors (1998)

We have demonstrated the use of superconducting transition edge sensors for the wide-band detection of individual photons from the mid infrared (IR), through the optical, and into the far ultraviolet (UV). These tungsten transition edge sensors are squares about 18 μm on a side and detect single photon events above a threshold of 0.3 eV (4 μm wavelength), with an energy resolution of 0.15 eV full width at half maximum, and with a risetime (falltime) of .5 μs (60 μs). The calibration data extend up to the UV cutoff of the fiber optic feed at 3.5 eV (350 nm).
Scattering Representations for Recognition (2013)

Ma thèse étudie le problème de la reconnaissance des objets et des textures. Dans ce cadre, il est nécessaire de construire des représentations de signaux avec des propriétés d'invariance et de stabilité qui ne sont pas satisfaites par des approches linéaires. Les opérateurs de Scattering itèrent des décompositions en ondelettes et rectifications avec des modules complexes. Ces opérateurs définissent une transformée non-linéaire avec des propriétés remarquables ; en particulier, elle est localement invariante par translation et Lipschitz continue par rapport à l'action des difféomorphismes. De plus, les opérateurs de Scattering définissent une représentation des processus stationnaires qui capture les moments d'ordre supérieur, et qui peut être estimée avec faible variance à partir d'un petit nombre de réalisations. Dans cette thèse, nous obtenons des nouvelles propriétés mathématiques de la représentation en scattering, et nous montrons leur efficacité pour la reconnaissance des objets et textures. Grâce à sa continuité Lipschitz par rapport à l'action des difféomorphismes, la transformée en scattering est capable de linéariser les petites déformations. Cette propriété peut être exploitée en pratique avec un classificateur génératif affine, qui nous permet d'obtenir l'état de l'art sur la reconnaissance des chiffres manuscrites. Nous étudions ensuite les représentations en Scattering des textures dans le cadre des images et du son. Nous montrons leur capacité à discriminer des phénomènes non-gaussiens avec des estimateurs à faible variance, ce qui nous permet d'obtenir de l'état de l'art pour la reconnaissance des textures. Finalement, nous nous intéressons aux propriétés du Scattering pour l'analyse multifractale. Nous introduisons une renormalisation des coéfficients en Scattering qui permet d'identifier de façon efficace plusieurs paramètres multifractales; en particulier, nous obtenons une nouvelle caractérisation de l'intermittence à partir des coefficients de Scattering ré-normalisés, qui peuvent s'estimer de façon consistante.
Multiobjetive H2/H control of a pitch regulated wind turbine for mechanical load reduction. (2017)

The paper deals with the design of acontrol system for a variable-speed pitch-regulatedwind turbine in the operating region correspond-ing to wind speeds above rated wind speed. Thecontrol objectives are mostly to regulate the plantoutput power and to reduce the mechanical fatigueof the plant components. The controller is designedfrom a non linear model of the system which takesinto account the blades, shaft and tower flexibil-ities. A Linear Matrix Inequalities (LMI) formu-lation of the control problem permits to obtaina Linear Parameter Varying (LPV) controller op-timizing, throughH2/H∞norm minimization, acriteria close to mechanical fatigue affecting theplant. The proposed controller performances arethen compared in simulation with those of a gainscheduling Linear Quadratic Gaussian (LQG) con-troller and with a gain scheduling PI controller, andis seen to be more efficient.
Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment (2021)

Pancreatic cancer is the fourth leading cause of cancer death. Existing therapies only moderately improve pancreatic ductal adenocarcinoma (PDAC) patient prognosis. The present study investigates the importance of the polyamine metabolism in the pancreatic tumor microenvironment. Relative mRNA expression analysis identified differential expression of polyamine biosynthesis, homeostasis, and transport mediators in both pancreatic epithelial and stromal cells from low-grade pancreatic intraepithelial neoplasia (PanIN-1) or primary PDAC patient samples. We found dysregulated mRNA levels that encode for proteins associated with the polyamine pathway of PDAC tumors compared to early lesions. Next, bioinformatic databases were used to assess expression of select genes involved in polyamine metabolism and their impact on patient survival. Higher expression of pro-polyamine genes was associated with poor patient prognosis, supporting the use of a polyamine blockade therapy (PBT) strategy for inhibiting pancreatic tumor progression. Moreover, PBT treatment of syngeneic mice injected intra-pancreatic with PAN 02 tumor cells resulted in increased survival and decreased tumor weights of PDAC-bearing mice. Histological assessment of PBT-treated tumors revealed macrophage presence and significantly increased expression of CD86, a T cell co-stimulatory marker. Collectively, therapies which target polyamine metabolism can be used to disrupt tumor progression, modulate tumor microenvironment, and extend overall survival.
6‐Chloro‐1‐Hexene and 8‐Chloro‐1‐Octene (2003)

Abstract 6‐chloro‐1‐hexene and 8‐chloro‐1‐octene intermediate: Allylmagnesium bromide reactant: allyl bromide (181.60 g, 1.50 mol) product: 6‐Chloro‐1‐hexene reactant: 1‐bromo‐3‐chloropropane (150.00 g, 0.95 mol) reactant: 1‐bromo‐5‐chloropentane (88.37 g, 0.47 mol) product: 8‐chloro‐1‐octene
Connecting RPC-Based Distributed Systems using Wide-Area Networks (1987)

Remote Procedure Call (RPC) is a widely used communication mechanism in local network based distributed operating systems. It is simple, fast, and straightforward to implement. However, when two or more distant distributed systems are connected, problems arise concerning the protocols, locating services, and other issues. To solve these problems, gateways are introduced. In this paper we discuss various ways in which these gateways can be organized and show how their application in the Amoeba Distributed Operating System has solved the problems cited above. 1. INTRODUCTION As networks of high-performance personal workstations become more widespread, interest in distributed operating systems to make the whole system look like a single timesharing system is increasing. When the same distributed operating system is running on two widely separated local-area networks, it is natural to think about merging them into a single transparent distributed system. However, because local-area and wi...
The video interface to high speed optical data transfer network (2005)

This paper describes the initial research and prototype design of the Video Interface to High Speed Optical Data Transfer Network. Image compression technique is used in order to increase network capacity. The Video Interface acquires video signals, compresses them, and sends out the packets of data to the communication channel. It also accepts compressed data from the communication channel, decompresses them, and drives the video monitor.
Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced‐dose chemotherapy on Children's Oncology Group trial A2971 (2012)

The COG A2971 trial reduced the chemotherapy dose and maintained survival to that achieved by the CCG 2891 trial in children who had myeloid leukemia associated with DS.
A TV program generation system using digest video scenes and a scripting markup language (2005)

This paper describes a TV program generation system using digest video scenes that are retrieved from video streams with the program indexes. The key features of the system are: (1) TV programs can be dynamically generated from digest video scenes selected by user preference. (2) Directions can be added using a happiness or sadness level based on the user preferences. (3) Personalized TV programs for an individual viewer can be made. The procedures taken by the system are as follows: (1) Conjunctive expressions between scenes are automatically generated; (2) Emotional expressions are automatically generated by user preference; (3) TV program metaphors are defined; (4) Direction templates corresponding to the metaphors are defined; (5) These expressions and definitions are coded using a markup language, and (6) Contents such as virtual characters and movies are synchronized. The resultant program can be shown on a TV set.
Utility of PCA3 urine assay in Japanese men undergoing prostate biopsy. (2011)

50 Background: Studies have shown the high specificity of PCA3 urine assay for biopsy detection of prostate cancer in European and American. We determined the diagnostic performance of PCA3 urine test in predicting prostate cancer in Japanese men. Methods: The study group included 261 men who underwent extended prostate biopsy at our institutions. 79 men of them had repeated biopsy. In all cases, race was Asian. Urine specimens were collected after digital rectal examination. On PROGENSA PCA3 assay, PCA3 score was calculated using PCA3 mRNA copy divided by PSA mRNA copy. PCA3 score was correlated with biopsy outcome and compared with serum PSA and free-total PSA. Results: 257 urine samples collected were successfully analyzed (i.e., the informative specimen rate was 98%). Biopsy revealed prostate cancer in 104 men (40%). There was no significant relationship between serum PSA and PCA3 score. PCA3 score in prostate cancer was significantly higher than that in negative (median 54.5 vs 17.0, p&lt;0.001). The probability of positive biopsy increased as PCA3 score increased. Using a PCA3 cutoff value of 35.0, sensitivity, specificity and diagnostic accuracy were 65%, 75% and 71%, respectively (p&lt;0.01). Area under the curve (AUC) for PCA3 score was 0.757 and AUC for serum PSA was 0.599 in all men. There was a significant difference in AUC between PCA3 score and serum PSA (p&lt;0.001). In men with serum PSA 4 to 10ng/ml, AUCs of PCA3 score, free-total PSA, and serum PSA were 0.759, 0.681, and 0.542, respectively. Conclusions: The specificity of PCA3 urine assay was high for detection of prostate cancer in Japanese men. PCA3 urine assay could improve the prediction for prostate cancer and help better decision making for prostate biopsy. No significant financial relationships to disclose.
Comparing personalized mean glandular dose estimates between x-ray systems over time in mammography (2014)

Poster: ECR 2014 / C-0360 / Comparing personalized mean glandular dose estimates between x-ray systems over time in mammography by: C. Tromans, A. Chan, R. Highnam; Wellington/NZ
Trabecular and Cortical Microstructure and Fragility of the Distal Radius in Women (2014)

Fragility fractures commonly involve metaphyses. The distal radius is assembled with a thin cortex formed by fusion (corticalization) of trabeculae arising from the periphery of the growth plate. Centrally positioned trabeculae reinforce the thin cortex and transfer loads from the joint to the proximal thicker cortical bone. We hypothesized that growth- and age-related deficits in trabecular bone disrupt this frugally assembled microarchitecture, producing bone fragility. The microarchitecture of the distal radius was measured using high-resolution peripheral quantitative computed tomography in 135 females with distal radial fractures, including 32 girls (aged 7 to 18 years), 35 premenopausal women (aged 18 to 44 years), and 68 postmenopausal women (aged 50 to 76 years). We also studied 240 fracture-free controls of comparable age and 47 healthy fracture-free premenopausal mother-daughter pairs (aged 30 to 55 and 7 to 20 years, respectively). In fracture-free girls and pre- and postmenopausal women, fewer or thinner trabeculae were associated with a smaller and more porous cortical area (r = 0.25 to 0.71 after age, height, and weight adjustment, all p < 0.05). Fewer and thinner trabeculae in daughters were associated with higher cortical porosity in their mothers (r = 0.30 to 0.47, all p < 0.05). Girls and premenopausal and postmenopausal women with forearm fractures had 0.3 to 0.7 standard deviations (SD) fewer or thinner trabeculae and higher cortical porosity than controls in one or more compartment; one SD trait difference conferred odds ratio (95% confidence interval) for fracture ranging from 1.56 (1.01-2.44) to 4.76 (2.86-7.69). Impaired trabecular corticalization during growth, and cortical and trabecular fragmentation during aging, may contribute to the fragility of the distal radius.