gebhart/patrepeval huggingface dataset:
Antigènes tissulaires de groupe sanguin ABH acteurs de la protection innée antivirale : exemples des Calicivirus (NV et RHDV) et du Coronavirus SRAS-CoV (2008)

Les antigenes tissulaires de groupe sanguin sont des motifs glycanniques presents sur les cellules epitheliales ou dans les secretions et egalement trouves sur les erythrocytes de certains primates. Leur synthese necessite l’action de glycosyltransferases codees par les genes Fut1, Fut2, Sec1 ou Abo. Ils servent de ligands a diverses souches de Calicivirus du genre norovirus responsables de gastro-enterites chez l’homme, le polymorphisme aux loci FUT2 et ABO controlant la sensibilite a ces virus. Dans ce travail nous montrons que le lait maternel contient des molecules de type mucine qui inhibent la fixation de la souche NV. L’inhibition est dependante de la presence d’un allele FUT2 permettant la synthese de glycannes α1,2fucosyles. Un autre Calicivirus, le RHDV, responsable de la maladie hemorragique du lapin (RHD), se fixe sur un glycanne α1,2fucosyle. Nous avons observe qu’il existe des lapins sauvages presentant un deficit d’expression de ce ligand dont la frequence dans les populations est augmentee a la suite d’epidemies de RHD. Un allele du gene Sec1 a pu etre associe a la survie des animaux, suggerant une selection par le virus. La proteine d’enveloppe du Coronavirus du SRAS lui permet de se fixer sur son recepteur cellulaire et peut porter des antigenes ABH. Des anticorps anti-A du plasma de sujets O inhibent la fixation de cette proteine sur son recepteur lorsqu’elle est synthetisee dans des cellules A, expliquant la plus grande sensibilite des individus A (ou B) au SRAS. Ainsi les antigenes de groupes sanguins tissulaires pourraient contribuer a la protection innee antivirale par des mecanismes complementaires, expliquant leur maintien au cours de l’evolution.
Layered Nanoparticle Architectures on Surfaces for Sensing and Electronic Functions (2003)

Nanoparticle architectures on surfaces reveal unique sensoric and electronic functions. For instance, receptor-crosslinked Au-nanoparticles on electrodes act as sensing interfaces by the concentration of analytes in receptor sites. The 3D conductivity of the layered arrays enables the electrochemical detection of substrates, and the sensitivity of the system is controlled by the number of nanoparticle layers. Layered structures of DNA-functionalized CdS-nanoparticles allow the optical and photoelectrochemical detection of DNA. The fluorescence and photocurrents resulting from the systems are controlled by the number of aggregated nanoparticle layers. Finally, the electroless deposition of gold on avidin-Au-nanoparticle conjugates provides a means for the amplified microgravimetric detection of DNA.
Saponins and microbial biosurfactants: Potential raw materials for the formulation of cosmetics (2018)

The cosmetic industry is currently one of the fasting growing sections of the economy in many countries. The recent tendency toward the use of cosmetics of a natural origin has driven the industry to seek alternatives to synthetic components in the formulation of products. Biosurfactants are natural compounds that have considerable potential for application in the formulation of safe, effective cosmetics as a replacement for commonly used chemical tensioactive agents. The present review provides essential information on the physicochemical and biological properties of saponins and microbial biosurfactants employed in cosmetic products, with a focus on the use of these natural compounds in shampoos, addressing the current state of research and patents involving biosurfactants for this purpose. The challenges and prospects of this cosmetic application are also discussed. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:1482-1493, 2018.
Scalable, Distributed, Real-Time Map Generation (2006)

In this application, many vehicles participate in the collection, processing, and dissemination of data to automatically generate digital road maps. Details about new roads and the modification or closure of existing roads must be incorporated into the databases in a timely fashion. Mapping organizations obtain data about road network changes from various sources, including local authorities and building contractors, but this data tends to be highly inaccurate. To simplify mapmaking process, vehicles could use their computational resources to directly generate accurate map data. We envisage vehicles on the road network forming a wide-scale mobile sensing and computing platform. Toward that goal, we've developed an algorithm for keeping digital maps up-to-date, using ordinary vehicles making normal journeys rather than fleets of dedicated probe vehicles. However, further development is required to address several remaining challenges, including the choice of architecture to support the algorithm
48.2: The Chemical Durability of EAGLE XG™ in LCD Dry Etch Processes (2007)

Abstract This work compared the chemical durability of EAGLE XG™, EAGLE 2000™ and Code 1737 glasses in typical TFT dry etch processes. Active, dielectric, and metal films were etched with a resist mask. Glass surfaces were evaluated by dark field microscopy, SEM/EDX, and AFM. The results show dry etch durability is comparable for all three compositions.
DIPG in Children – What Can We Learn from the Past? (2015)

Brainstem tumors represent 10-15% of pediatric central nervous system tumors and diffuse intrinsic pontine glioma (DIPG) is the most common brainstem tumor of childhood. DIPG is almost uniformly fatal and is the leading cause of brain tumor-related death in children. To date, radiation therapy (RT) is the only form of treatment that offers a transient benefit in DIPG. Chemotherapeutic strategies including multi-agent neoadjuvant chemotherapy, concurrent chemotherapy with RT, and adjuvant chemotherapy have not provided any survival advantage. To overcome the restrictive ability of the intact blood-brain barrier (BBB) in DIPG, several alternative drug delivery strategies have been proposed but have met with minimal success. Targeted therapies either alone or in combination with RT have also not improved survival. Five decades of unsuccessful therapies coupled with recent advances in the genetics and biology of DIPG have taught us several important lessons (1). DIPG is a heterogeneous group of tumors that are biologically distinct from other pediatric and adult high grade gliomas (HGG). Adapting chemotherapy and targeted therapies that are used in pediatric or adult HGG for the treatment of DIPG should be abandoned (2). Biopsy of DIPG is relatively safe and informative and should be considered in the context of multicenter clinical trials (3). DIPG probably represents a whole brain disease so regular neuraxis imaging is important at diagnosis and during therapy (4). BBB permeability is of major concern in DIPG and overcoming this barrier may ensure that drugs reach the tumor (5). Recent development of DIPG tumor models should help us accurately identify and validate therapeutic targets and small molecule inhibitors in the treatment of this deadly tumor.
New preparation of [123I]PE2I: investigation of the oxidation and purification steps (2002)

Abstract In order to simplify preparation of [ 123 I]PE2I, iodogen and hydrogen peroxide were examined as oxidants for the preparation of radioiodinated PE2I, e.g. ( E )‐ N ‐(3‐iodoprop‐2‐enyl)‐2 β ‐carbomethoxy‐3 β ‐(4′‐tolyl) nortropane). Among the oxidizing compounds assayed, iodogen appears to afford the best results for this purpose (high radiochemical yield, high chemical purity and a reasonable reaction time). A simplified and efficient method is described here for the preparation of [ 123 I]PE2I based on the exchange of a 123 I tributyl tin analogue in oxidative conditions followed by purification by solid phase extraction (SPE). Using this method, [ 123 I]PE2I was obtained with a radio‐pharmaceutical yield over 60%, with chemical and radiochemical purities higher than 95% without the addition of a carrier (Na 127 I) (2G Bq/nmol) or with a specific activity adjusted to 85–90 MBq/nmol in the presence of the carrier. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Application of microgels for optical tagging (2004)

In this paper we present results from our research into the use of microgel-based photonic crystals in an optical tagging application. The basis for this research is the phenomena of self-assembly of hydrogel nano- and microparticles (i.e., microgels) into colloidal crystal Bragg reflectors. Previous research has demonstrated the assembly of Bragg structures that are sensitive in the visible spectral region. This current research focuses on the extension of this process into the infrared regime and the use of these infrared-sensitive structures in the creation of an optical tag. In particular, the research effort emphasizes two primary areas: the development of nanoparticles that are infrared-sensitive and the casting of thin films comprised of these particles. We will also present theoretical data on the optical and physical characteristics of thin films comprised of these particles. This paper will present an overview of the program, outline the processes and issues addressed during our initial efforts in creating these infrared sensitive structures and present a summary of the computational results based on the theoretical analyses.
Attenuating Sulfidogenesis in a Soured Continuous Flow Column System With Perchlorate Treatment (2018)

Hydrogen sulfide production by sulfate reducing bacteria (SRB) is the primary cause of oil reservoir souring. Amending environments with chlorate or perchlorate [collectively denoted (per)chlorate] represents an emerging technology to prevent the onset of souring. Recent studies with perchlorate reducing bacteria (PRB) monocultures demonstrated that they have the innate capability to enzymatically oxidize sulfide, thus PRB may offer an effective means of reversing souring. (Per)chlorate may be effective by (i) direct toxicity to SRB; (ii) competitive exclusion of SRB by PRB; or (iii) reversal of souring through re-oxidation of sulfide by PRB. To determine if (per)chlorate could sweeten a soured column system and assign a quantitative value to each of the mechanisms we treated columns flooded with San Francisco bay water with temporally decreasing amounts (50, 25, and 12.5 mM) of (per)chlorate. Geochemistry and the microbial community structure were monitored and a reactive transport model was developed, Results were compared to columns treated with nitrate or untreated. Souring was reversed by all treatments at 50 mM but nitrate-treated columns began to re-sour when treatment concentrations decreased (25 mM). Re-souring was only observed in (per)chlorate-treated columns when concentrations were decreased to 12.5 mM and the extent of re-souring was less than the control columns. Microbial community analyses indicated treatment-specific community shifts. Nitrate treatment resulted in a distinct community enriched in genera known to perform sulfur cycling metabolisms and genera capable of nitrate reduction. (Per)chlorate treatment enriched for (per)chlorate reducing bacteria. (Per)chlorate treatments only enriched for sulfate reducing organisms when treatment levels were decreased. A reactive transport model of perchlorate treatment was developed and a baseline case simulation demonstrated that the model provided a good fit to the effluent geochemical data. Subsequent simulations teased out the relative role that each of the three perchlorate inhibition mechanisms played during different phases of the experiment. These results indicate that perchlorate addition is an effective strategy for both souring prevention and souring reversal. It provides insight into which organisms are involved, and illuminates the interactive effects of the inhibition mechanisms, further highlighting the versatility of perchlorate as a sweetening agent.
Simulated characterization of atherosclerotic lesions in the coronary arteries by measurement of bioimpedance (2003)

FEM software was used to determine the feasibility of characterizing various types of atherosclerotic lesions in vivo. This was accomplished by simulating two electrodes as being attached to an angioplasty balloon in the coronary artery. The electrodes on the "balloon" touched and measured the simulated complex impedance of type III, IV, and Va and Vb lesions, as defined by the American Heart Association (AHA). Additionally, the effect of changes in morphology on the complex impedance was determined for type Va and Vb lesions. The simulations showed that the layer closest to the electrodes had the most significant effect on the measured complex impedance. As a consequence of these simulations, it appears plausible that electrodes could be placed in vivo to determine the characteristics and type of a given atherosclerotic lesion.
Multicultural Students', Parents' and Teachers' Ideas about Science Learning (2013)

우리 사회의 소중한 자산이 될 다문화 학생들을 위한 과학 교육적 배려를 제공하기 위한 목적으로 본 연구가 기획되었다. 다문화 학생들이 생각하고 있는 과학 학습을 파악하여 그들의 상황을 이해하고 과학 교육 차원에서 배려하고 지원하는 방향을 고민함으로써 그들을 고려한 과학 교육계의 관심을 불러일으키고자 한다. 이를 위해 다문화 가정 초등 및 중등 학생과 학부모, 그리고 다문화 학생들을 가르치고 있는 초등 교사 및 중등 과학 교사들을 대상으로 집단 면담을 실시했다. 면담을 통해 다문화 학생들의 과학 교육에 있어서 무엇보다도 언어적 지원이 필요하다는 점을 발견했다. 이 밖에도 다문화 학생들을 바라보는 교사와 친구들의 기대치가 낮다는 점도 알았다. 우리 상황에 맞는 다문화 과학 교육의 내용과 방법, 그리고 학교 차원의 제도적 지원을 통해 모든 사람을 위한 과학적 소양을 실천해야 할 것이다. This study was initiated to address multicultural students' science learning, which is expected to be our assets for the next generation. By understanding their ideas of science learning and cultural context, we intend to encourage them and urge our science education communities to be interested in multicultural science education in Korea. We interviewed elementary and secondary school multicultural students, their parents, and teachers who have ever taught them. The interview revealed that they needed language-based support to improve their science learning. It seemed to be a serious problem that teachers' and students' expectancy toward multicultural students were low. We should put into practice scientific literacy for all students through the multicultural science education in our own context with school-based systematic support.
Modulation spectroscopy of Rydberg atoms in an optical lattice (2020)

We develop and study quantum and semiclassical models of Rydberg-atom spectroscopy in amplitude-modulated optical lattices. Both initial- and target-state Rydberg atoms are trapped in the lattice. Unlike in other spectroscopic schemes, the modulation-induced ponderomotive coupling between the Rydberg states is spatially periodic and perfectly phase-locked to the lattice trapping potentials. This leads to a type of sub-Doppler mechanism which we explain in detail. In our exact quantum model, we solve the time-dependent Schr\"odinger equation in the product space of center-of-mass (COM) momentum states and the internal-state space. We also develop a perturbative model based on the band structure in the lattice and Fermi's golden rule, as well as a semiclassical trajectory model in which the COM is treated classically and the internal-state dynamics quantum-mechanically. In all models we obtain the spectrum of the target Rydberg-state population versus the lattice modulation frequency, averaged over the initial thermal COM momentum distribution of the atoms. We investigate the quantum-classical correspondence of the problem in several parameter regimes and exhibit spectral features that arise from vibrational COM coherences and rotary-echo effects. Applications in Rydberg-atom spectroscopy are discussed.
Library Retrieval of Infrared Spectra Based on Detailed Intensity Information (1979)

Infrared spectral searches which rely on detailed intensity information and those based on peak position information are compared using a library of 500 reference spectra. Spectra with detailed intensity information are encoded with absorbance values for 200 resolution increments spanning the range from 4000 to 200 cm −1 . Three different distance metrics are evaluated for searches using intensity information, and the effects of selecting data from limited regions of the infrared spectrum are examined.
Serial measurement of lipid profile and inflammatory markers in patients with acute myocardial infarction (2015)

Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 patients with AMI who were admitted within 24 h of onset of symptoms. Serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were determined by standard enzymatic methods along with high sensitive C-reactive protein (hs-CRP) (latex enhanced immunoturbidimetric assay) and cytokines, interleukin (IL)-6 and IL-10 (quantitative ''sandwich'' enzyme-linked immunosorbent assay). The results indicate a trend of reduced TC, LDL, and HDL, and elevated TG levels, along with pro- and anti-inflammatory markers (p < 0.001), between day 1 and the day 2 serum samples of AMI patients. However, corrections in the serum levels have been observed at day 7. Our results demonstrate significant variations in the mean lipid levels and inflammatory markers between days 1, 2 and 7 after AMI. Therefore, it is recommended that the serum lipids should be assessed within 24 hours after infarction. Early treatment of hyperlipidemia provides potential benefits. Exact knowledge regarding baseline serum lipids and lipoprotein levels as well as their varying characteristics can provide a rational basis for clinical decisions about lipid lowering therapy.
Study 15: Replication of Sugahara et al., 2010 (Science) (2013)

Replication of "Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs”. Includes information to prepare the replication experiments. Includes data, code, and digital materials from completed replication experiments.
Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents (2020)

These results suggest that the identified 1H-1,2,3-triazole-linked quinoline-isatin hybrids are viable chemotypes that can be adopted as templates for the development of new anti-breast cancer and anti-MRSA agents.
Die Wirtschaftlichkeit der Werkstoffauswahl und des Korrosionsschutzes in der chemischen Industrie (1964)

Abstract Nach einem kurzen Überblick über die vielfältigen Anforderungen an die in der chemischen Industrie einzusetzenden Werkstoffe sowie über die erforderlichen Maßnahmen des aktiven und passiven Korrosionsschutzes wird auf die Notwendigkeit systematischer Wirtschaftlichkeitsvergleiche zur Ausschaltung der Heterogenität der technischen Daten hingewiesen. Die heutige Ausdehnung und Komplizierung des Fachgebietes legt bei hinreichender Betriebsgröße in den Chemiebetrieben eine Spezialisierung und organisatorische Verselbständigung nahe. Nach den bisherigen Erfahrungen wird die Eingliederung innerhalb der Projektabteilung der technischen Verwaltung bevorzugt. Ein Hauptabschnitt des Aufsatzes befaßt sich mit Werkstoff‐ und Korrosionsgesichtspunkten bei der Projektierung von Neuanlagen, wobei die chemische und verfahrenstechnische Festlegung des Prozesses, die Werkstoffauswahl selbst, die Konstruktion der Anlagen, Verarbeitungsverfahren der Werkstoffe und Montagetechnik sowie die Standortwahl behandelt werden. Anschließend werden die geeigneten Methoden der Wirtschaftlichkeitsrechnung bei der Projektierung erörtert, nämlich der Vergleich der Anschaffungskosten, der Kostenvergleich sowie der Vergleich verschiedener Rentabilitätskennziffern, wobei die Rechenmethoden durch Beispiele belegt werden. Eine Betrachtung über die Wirtschaftlichkeit van Korrosionsschutzmaßnahmen im laufenden Betrieb schließt folgende Teilgebiete ein: Ermittlung und laufende Beobachtung der atmosphärischen Angriffsbedingungen im Werksbereich, Festlegung und technischer Vergleich der geeigneten Korrosionsschutzsysteme, Wirtschaftlichkeitsvergleich der Korrosionsschutzsysteme, allgemeine laufende Wirtschaftlichkeitskontrolle des atmosphärischen Korrosionsschutzes, Maßnahmen der Planung und Organisation.
Antidepressive-like effect of imperatorin from Angelica dahurica in prenatally stressed offspring rats through 5-hydroxytryptamine system (2017)

Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes. Prenatally stressed offspring rats were used to investigate the potential antidepressive-like effects of imperatorin (IMP) extracted from the root of radix angelica. After 4 weeks of treatment of IMP, behavioral tests (sucrose-preference test, forced-swimming test, and open-field test) were measured. 5-hydroxytryptamine (5-HT) concentration in the hippocampus and frontal cortex was measured using an enzyme-linked immunosorbent assay. Serotonin transporters (5-HTT) and 5-HT1A receptor (5-HT1AR) mRNA expression in the hippocampus and frontal cortex were also determined by real-time PCR. Administration with IMP (15 and 30 mg/kg/day, intragastrically) for 28 days markedly increased the percentage of sucrose (anhedonia), decreased the immobility time, and increased the number of total crossings, center crossings, rearing, and grooming in the male prenatally stressed offspring. Meanwhile, we found that 5-HT concentration in the hippocampus and frontal cortex was significantly increased in the IMP-treated group. Subsequently, we found significantly decreased 5-HTT and increased 5-HT1AR mRNA expressions in the hippocampus and frontal cortex after IMP treatment in the prenatally stressed male offspring. IMP showed antidepressive-like effects and increased 5-HT concentration in male prenatally stressed offspring, suggesting that IMP could be of therapeutic use in preventing depressive-like behavior in adolescence.