gebhart/patrepeval huggingface dataset:
Dynamically Reconfigurable Discrete Distributed Stiffness for Inflated Beam Robots (2020)

Inflated continuum robots are promising for a variety of navigation tasks, but controlling their motion with a small number of actuators is challenging. These inflated beam robots tend to buckle under compressive loads, producing extremely tight local curvature at difficult-to-control buckle point locations. In this paper, we present an inflated beam robot that uses distributed stiffness changing sections enabled by positive pressure layer jamming to control or prevent buckling. Passive valves are actuated by an electromagnet carried by an electromechanical device that travels inside the main inflated beam robot body. The valves themselves require no external connections or wiring, allowing the distributed stiffness control to be scaled to long beam lengths. Multiple layer jamming elements are stiffened simultaneously to achieve global stiffening, allowing the robot to support greater cantilevered loads and longer unsupported lengths. Local stiffening, achieved by leaving certain layer jamming elements unstiffened, allows the robot to produce "virtual joints" that dynamically change the robot kinematics. Implementing these stiffening strategies is compatible with growth through tip eversion and tendonsteering, and enables a number of new capabilities for inflated beam robots and tip-everting robots.
Editorial: a methods article (2019)

Everyone at Supramolecular Chemistry, from the Editors and the Advisory Board to the many Taylor and Francis staff who make it all possible, strive to make Supramolecular Chemistry a thriving journ...
01: Kognitive Systeme, Vorlesung, SS 2019, 29.04.2019 (2019)

01 | 0:00:00 Start 0:00:05 Organisatorisches 0:19:42 Signal(vor)verarbeitung 0:26:14 Erfassen / Messen von Signalen 0:27:51 Faltung 0:28:54 Digitalisierung 0:29:37 Abtasten 0:31:15 Quantisierung 0:34:56 Sampling - Aliasing 0:37:48 Digitalisierung von Sprache 0:43:57 Multiplexen 0:46:22 Mathematische Betrachtung der Digitalisierung von Signalen (Dirac Funktion) 0:50:50 Faltung 1:04:16 Wichtiges Beispiel Faltung
Electrochromic Properties of Li+-Intercalated Amorphous Tungsten (aWO3-x) and Titanium (aTiO2-x) Oxide Thin Films (2014)

We report on electrochromic properties of stoichiometric and oxygen-deficient amorphous films, denoted aWO(3-x) and aTiO(2-x), under Li+-ion-electron inter/deintercalation. Optical characterization of the films in their as-deposited, fully intercalated (dark), and bleached states were performed by in-situ optical transmittance measurements. We explore electrochromism and optical absorption phenomena in the context of oxygen deficiency and nanostructure. Studies by cyclic voltammetry suggest good optical modulation and charge capacity upon Li+-ion-electron inter/deintercalation for almost stoichiometric films.
Challenges and implications of using ultrasonic communications in intra-body area networks (2012)

Body area networks (BANs) promise to enable revolutionary biomedical applications by wirelessly interconnecting devices implanted or worn by humans. However, BAN wireless communications based on radio-frequency (RF) electromagnetic waves suffer from poor propagation of signals in body tissues, which leads to high levels of attenuation. In addition, in-body transmissions are constrained to be low-power to prevent overheating of tissues and consequent death of cells. To address the limitations of RF propagation in the human body, we propose a paradigm shift by exploring the use of ultrasonic waves as the physical medium to wirelessly interconnect in-body implanted devices. Acoustic waves are the transmission technology of choice for underwater communications, since they are known to propagate better than their RF counterpart in media composed mainly of water. Similarly, we envision that ultrasound (e.g., acoustic waves at non-audible frequencies) will provide support for communications in the human body, which is composed for 65% of water. In this paper, we first assess the feasibility of using ultrasonic communications in intra-body BANs, i.e., in-body networks where the devices are biomedical sensors that communicate with an actuator/gateway device located inside the body. We discuss the fundamentals of ultrasonic propagation in tissues, and explore important tradeoffs, including the choice of a transmission frequency, transmission power, bandwidth, and transducer size. Then, we discuss future research challenges for ultrasonic networking of intra-body devices at the physical, medium access and network layers of the protocol stack.
EVOLUTION OF RENAL FUNCTION DURING TREATMENT OF KIDNEY GRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODY (1990)

GOLDMAN, MICHEL; LAETHEM, JEAN-LUC VAN; ABRAMOWICZ, DANIEL; PAUW, LUC DE; KINNAERT, PAUL; VEREERSTRAETEN, PIERRE Author Information
A Novel Synthesis of Symmetric Ketones by the Reaction of Organoboranes with Catechol Dichloromethylene Ether in the Presence of Methyllithium (1982)

a i l a b l e from alkenes v i a hydroboration react w i t h catechol dichloromethylene ether i n the presence o f methyllithium followed by the usual a l k a l i n e hydrogen peroxide oxidation t o give correspon-
Toward a Realistic Modeling of the Photophysics of Molecular Building Blocks for Energy Harvesting: The Charge-Transfer State in 4,7-Dithien-2-yl-2,1,3-benzothiadiazole As a Case Study (2013)

Theoretical modeling of the photophysical properties of materials (both low-weighted and polymeric) for energy harvesting represents an attractive area of fundamental and applied research. In this area meaningful results can be obtained only in the presence of realistic models keeping intact the atomistic complexity which, in this system, is usually very high. Herein we propose a model study, carried out on a typical building block for energy harvesting materials, 4,7-dithien-2-yl-2,1,3-benzothiadiazole (DTB), with the precise aim to theoretically reproduce the charge-transfer S0–S1 UV–vis signal in different solvents and also to provide some hints for interpreting the large Stokes-shift observed in its fluorescence spectra. Results show that the DTB spectral (absorption) features are the result of an intimate interplay between chromophore thermal fluctuations and environmental dynamical (electrostatic) perturbation. Deep inspection of the results also confirms the possibility of modulating the chromophore low-energy photophysics acting on the thermal, electrical, and chemical properties of the molecular surrounding environment.
Theoretical and phase contrast microscopic eigenmode analysis of erythrocyte flicker : amplitudes (1992)

The energy eigenmodes of an erythrocyte with elastic properties described by a curvature modulus kc and a shear modulus μ are computed, both for fixed spontaneous curvature c0, and in the bilayer coupling hypothesis (fixed 〈H〉). The corresponding thickness fluctuation profiles depend on the relative importance of kc and μ. A phase contrast microscopy determination of the thickness fluctuation profile indicates that μ, at least in this process, is very small. The data favor fixed 〈H〉 over fixed c0. kc is about 4.3×10-19 J if c0 fixed and 1.4×10-19 J if 〈H〉 is fixed.
Hypotensive activity of beta-heptamethylenimino-ethylaminoguanidine sulfate. (1966)

β- Heptamethyleniminoethylaminoguanidine sulfate, EX 4891A, has been shown to be a potent hypotensive agent in the anesthetized rat, cat and dog and in the unanesthetized renal hypertensive dog. This compound was found to have a short-term direct vasodilator effect in the denervated hind limb of the dog. Interference with sympathetic neuronal activity was found in both the in vivo nictitating membrane-superior cervical ganglion preparation in cats and the in vitro isolated innervated rabbit ileum preparation. Cross-circulation studies in dogs indicated a lack of a centrally mediated hypotensive effect. EX 4891A depleted catecholamines from the rat ventricle but did not exhibit a sympathomimetic effect due to an acute release of catecholamines in active forms.
Deep tracking in the wild: End-to-end tracking using recurrent neural networks (2017)

This paper presents a novel approach for tracking static and dynamic objects for an autonomous vehicle operating in complex urban environments. Whereas traditional approaches for tracking often feature numerous hand-engineered stages, this method is learned end-to-end and can directly predict a fully unoccluded occupancy grid from raw laser input. We employ a recurrent neural network to capture the state and evolution of the environment, and train the model in an entirely unsupervised manner. In doing so, our use case compares to model-free, multi-object tracking although we do not explicitly perform the underlying data-association process. Further, we demonstrate that the underlying representation learned for the tracking task can be leveraged via inductive transfer to train an object detector in a data efficient manner. We motivate a number of architectural features and show the positive contribution of dilated convolutions, dynamic and static memory units to the task of tracking and classifying complex dynamic scenes through full occlusion. Our experimental results illustrate the ability of the model to track cars, buses, pedestrians, and cyclists from both moving and stationary platforms. Further, we compare and contrast the approach with a more traditional model-free multi-object tracking pipeline, demonstrating that it can more accurately predict future states of objects from current inputs.
Cased Hole Exploration and Recompletions in West Texas Based on the Continuous Carbon/Oxygen (C/O) Log (1981)

ABSTRACT Recent field experiences in West Texas with the Continuous Carbon/Oxygen (C/O) Log illustrate the potential of this cased hole logging service to assist in the re-evaluation of partially depleted oil reserves and exploration for by-passed oil in old wells in mature, producing areas. Interpretive concepts and possible pitfalls are outlined for quick-look evaluation at the wellsite and detailed computerized analysis. Field case examples, including the results of subsequent production tests in the Yates, Seven Rivers, Queen, Grayburg, San Andres, Glorieta, and Clearfork formations illustrate successful applications of the C/O Log in West Texas.
Advances in ultrasonic controllers – new energy-saving solutions for pump control (2006)

Pumps are the largest user of energy in a water and wastewater plant. Effective pump management is vital if energy costs are to be controlled. For many ultrasonic technology is the preferred tool of choice and in this article David Hewitt, product manager at Siemens Automation and Drives, explains how advanced ultrasonic controllers can give the user the power of pump control in order to improve the bottom line.
Comparison of Parallel and Series Hybrid Power Trains for Transit Bus Applications (2016)

The fuel economy and emissions of conventional and hybrid buses equipped with emissions aftertreatment were evaluated via computational simulation for six representative city bus drive cycles. Both series and parallel configurations for the hybrid case were studied. The simulation results indicated that series hybrid buses have the greatest overall advantage in fuel economy. The series and parallel hybrid buses were predicted to produce similar carbon monoxide and hydrocarbon tailpipe emissions but were also predicted to have reduced tailpipe emissions of nitrogen oxides compared with the conventional bus in higher speed cycles. For the New York bus cycle, which has the lowest average speed among the cycles evaluated, the series bus tailpipe emissions were somewhat higher than they were for the conventional bus; the parallel hybrid bus had significantly lower tailpipe emissions. All three bus power trains were found to require periodic active diesel particulate filter regeneration to maintain control of particulate matter. Plug-in operation of series hybrid buses appears to offer significant fuel economy benefits and is easily employed because of the relatively large battery capacity that is typical of the series hybrid configuration.
Minimum order graphs with specified diameter, connectivity, and regularity (1989)

Abstract Relationships among graph invariants such as the number of vertices, diameter, connectivity, maximum and minimum degrees, and regularity are being studied recently, motivated by their usefulness in the design of fault‐tolerant and low‐cost communication and interconnection networks. A graph is called a ( d , c , r ) graph if it has diameter d , connectivity c , and regularity r . The minimum number of vertices in ( d , 1,3), ( d ,2,3), ( d ,3,3), and ( d , c , c ) graphs have been reported in the literature. In this paper, the minimum number of vertices in a ( d , c , r ) graph with r &gt; c is determined, thereby exhausting all the possible choices of values for d , c , and r . Our proof is constructive and hence we get a collection of optimal ( d , c , r ) graphs.
Abstract 4653: Melanocyte specific deletion of Map3k1 reveals its role in BRAFV600E-driven melanoma (2019)

Abstract BRAF is the most common driver oncogene in cutaneous melanoma. Activating mutations in the BRAF gene are enriched in melanomas associated with intermittent sun exposure, with the most frequent mutations occurring at codon 600, leading to a constitutive activation of the RAF/MEK/ERK signaling pathway. In previous studies, we demonstrated that ultraviolet radiation (UVR) accelerates melanomagenesis in a mouse model of melanoma driven by BRAFV600E. From whole exome sequencing analysis of the tumors we found that Map3k1 was the most recurrently mutated gene across different experimental cohorts. MAP3K1 is unique in having both a kinase and E3 ligase function, allowing it to regulate protein phosphorylation and ubiquitin-mediated proteasome degradation. The vast majority of the mutations in Map3k1 occurred within the RING domain, which contains the E2 binding site for ubiquitin-conjugating enzymes. The most prevalent non-synonymous mutations where present in codon 484 and arose as a consequence of C-to-T transitions at a dipyrimidine site, characteristic of UVR-induced DNA damage. To understand better the role of MAP3K1, we generated Tyr::CreERT2+/o;Map3k1f/f mice allowing us to conditionally delete Map3k1 specifically in the melanocytes upon topical application of tamoxifen to the dorsal skin of juvenile mice. These mice did not develop tumors, but when crossed to mice carrying a Braf+/LSL-V600E allele, all mice develop melanoma, with a shorter latency and an increased multiplicity compared to Tyr::CreERT2+/o;Braf+/LSL-V600E mice. Tumors showed similar histopathological features, but melanomas carrying Map3k1 floxed or mutant variants presented higher levels of phosphorylated ERK1/2 than those with wild-type Map3k1. In addition, analysis of expression data of human cutaneous melanomas from The Cancer Genome Atlas showed an inverse correlation between the expression of MAP3K1 and ERK2 protein levels. Taken together, our results suggest that MAP3K1 loss-of-function cooperates with BRAFV600E to drive melanoma development by increasing MEK-ERK pathway activation. Citation Format: Lucas D. Trucco, Piyushkumar A. Mundra, Pablo Garcia-Martinez, Kate Hogan, Nathalie Dhomen, Valeria Pavet, Richard Marais. Melanocyte specific deletion of Map3k1 reveals its role in BRAFV600E-driven melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4653.
New Condensation Polymer Precursors Containing Consecutive Silicon Atoms—Decaisopropoxycyclopentasilane and Dodecaethoxyneopentasilane—And Their Sol–Gel Polymerization (2019)

The sol-gel polymerization of alkoxysilanes is a convenient and widely used method for the synthesis of silicon polymers and silicon-organic composites. The development of new sol-gel precursors is very important for obtaining new types of sol-gel products. New condensation polymer precursors containing consecutive silicon atoms-decaisopropoxycyclopentasilane (CPS) and dodecaethoxyneopentasilane (NPS)-were synthesized for the preparation of polysilane-polysiloxane material. The CPS and NPS xerogels were prepared by the sol-gel polymerization of CPS and NPS under three reaction conditions (acidic, basic and neutral). The CPS and NPS xerogels were characterized using N<sub>2</sub> physisorption measurements (Brunauer-Emmett-Teller; BET and Brunauer-Joyner-Halenda; BJH), solid-state CP/MAS (cross-polarization/magic angle spinning) NMRs (nuclear magnetic resonances), TEM, and SEM. Their porosity and morphology were strongly affected by the structure of the precursors, and partial oxidative cleavage of Si-Si bonds occurred during the sol-gel process. The new condensation polymer precursors are expected to expand the choice of approaches for new polysilane-polysiloxane.
The Effect of Kinematical Parameters and Tool Geometry on Burr Height in Face Milling of Al-Si Alloys (2003)

High speed face milling test were performed on two aluminum silicon alloys currently used in automotive engine production to study the effect of cutting parameters and tool geometry in edge quality. Axial Rake and Radial Rake angles were varied to assess their effect in burr formation, as well as cutting speed, feedrate and depth of cut. Significant improvements in edge quality were obtained by optimizing these geometrical and kinematical parameters.
Pharmacotherapeutic options for atypical meningiomas (2019)

<b>Introduction</b>: Atypical meningiomas are aggressive tumors associated with high rates of recurrence and mortality. Current therapy is surgical resection followed by radiotherapy which has reasonable success rates. However, there are cases where surgical resection is not possible, and radiotherapy is not advisable. <b>Areas covered</b>: In this short review, the authors have searched the current literature for explorations of adjuvant treatments such as chemotherapy and pharmaceutical agents. Most current chemotherapeutic agents have been unsuccessful in producing radiographic reduction or disease stabilization, although drugs like somatostatin analogs and plant-derived chemotherapeutics have shown some promise. The authors note that most of the studies in this field have been case series with a few randomized trials present. This makes it hard to ascertain the effectiveness of the drugs and so further research is required in the field. <b>Expert opinion</b>: Finding pharmacotherapies to combat atypical meningiomas needs Big data genomic analysis. This will assist in generating drug candidates and a multidrug approach to therapy that will exploit several of the pathological pathways of atypical meningiomas. Using multidrug therapy that affects several pathways also addresses the issue of meningioma heterogeneity and adaptability.
Toward the gram -scale total synthesis of (+)-spongistatin 1 (2004)

This dissertation describes the evolution of a large-scale synthetic campaign directed at the total synthesis (+)-spongistatin 1, one of the most potent and architecturally complex antitumor marine macrolides discovered to date. Chapter one provides an introduction to the spongistatin family of natural products. Specifically, the isolation, structure elucidation, and biological activity of the spongistatins are discussed. Furthermore, relevant synthetic approaches toward the spongistatins are delineated.* Chapter two provides a critical analysis of our previous syntheses of the spongistatins in the form of a detailed retrosynthesis, and describes our latest synthetic strategy for overcoming the deficiencies associated with our earlier work. The (+)-spongistatin 1 macrolide framework was assembled via Wittig union of an EF phosphonium salt and an ABCD aldehyde. For construction of the advanced ABCD fragment, disconnection at the C(15)-C(16) aldol linkage revealed the AB aldehyde and CD ketone. The linear precursors of both spiroketal moieties were assembled in a highly efficient manner via methods developed in our laboratories, namely the three component union of 2-silyl-1,3-dithianes with terminal epoxides.* As anticipated from the precedent set forth by Evans, aldol union of the AB and CD fragments proceeded in both good yield (72%) and with high selectivity (9:1). The complex aldol reaction was ultimately performed on a 2 g scale; approximately 5 g of coupled product were prepared. The synthesis of the advanced ABCD aldehyde was achieved with a longest linear sequence of 22 steps (6.5% overall yield) and is 15 steps shorter than our previous synthesis.* Chapters three and four describe our long-standing efforts toward an efficient and scalable synthesis of the EF Wittig salt. The difficulty in this regard lies in the installation of the highly sensitive chlorodiene side chain moiety present in (+)-spongistatin 1. In response, we have developed a novel method for side chain introduction via cyanohydrin alkylation. Construction of the EF bis-tetrahydropyran subunit was achieved via dithiane alkylation to an F-ring aldehyde, using chelation control to establish the requisite C(38) stereochemistry.* Successful installation of the chlorodiene side chain was achieved via cyanohydrin alkylation of an appropriately functionalized EF bis-tetrahydropyran allyl iodide. Subsequent synthetic operations, involving cyanohydrin hydrolysis, elimination to afford the diene moiety, asymmetric ketone reduction, and phosphonium salt formation completed the synthesis of the EF Wittig salt.* (Abstract shortened by UMI.) *Please refer to dissertation for diagrams.
Coexistence of 2k/sub F/ and 4k/sub F/ instabilities in a model of a 1D electron gas (1988)

By a combination of field theory techniques and numerical solutions of finite chains, we have determined the phase diagrams of a 1D electron gas quarter filled band model in the extreme U = infinity limit : repulsive first and second neighbor interactions drive the system to one or the other of two Wigner lattices with 2k/sub F/ or 4K/sub F/ periodicity. When the electron delocalization exceeds a critical value, these long-range orders are destroyed and correlation functions with algebraic behavior are obtained. We emphasize the possible coexistence of 4k/sub F/-bond and 2k/sub F/-site orders in a region of the phase diagram and comment on the relevance of these results for understanding experimental observations. 7 refs., 4 figs.
Survival of ice nucleation-active and genetically engineered inactive strains of Pseudomonas syringae (2019)

The survival of ice nucleation-active (INA) and genetically engineered non-INA strains of Pseudomonas syringae was compared under starvation and freezing conditions. In starvation experiments, both strains displayed similar survival curves and recovery from starvation was nearly identical for the two strains. In freezing experiments, oat seedlings colonized by each strain were subjected to freezing temperatures. Populations of the INA strain increased 15-fold in the 18 hours after oat plants incurred frost damage at {dollar}-{dollar}5 and {dollar}-{dollar}12{dollar}\sp\circ{dollar}C. Plants colonized by the non-INA strain were undamaged at {dollar}-{dollar}5{dollar}\sp\circ{dollar}C and exhibited no changes in population size. As temperatures were lowered, plants colonized by the non-INA strain suffered increased frost damage concomitant with bacterial population increases. At {dollar}-{dollar}12{dollar}\sp\circ{dollar}C, both strains behaved identically. The data show a relationship between frost damage to plants and subsequent increased bacterial population size, indicating a potential competitive advantage for INA strains of P. syringae in mild freezing environments.