gebhart/patrepeval huggingface dataset:
Fluidic self-assembly of microstructures and its application to the integration of GaAs on Si (2002)

A new technique for the self-assembly of microstructures is demonstrated in this paper. Freed microstructures suspended in a fluid are assembled onto a host substrate by fluidic transport. The microstructures are fabricated with specific binding features. They are freed from their original substrate by sacrificial etching and transferred into an inert carrier fluid. Before the microstructures are freed, they can also be bonded to an intermediate substrate where their original-substrate is removed. This provides access to the other side of the microstructures for processing before they are freed into the carrier fluid. The fluid is then dispensed onto a host substrate with specific features to control the positioning and the orientation of the microstructures. In this way an abundance of microstructures can be made in advance and assembled onto the substrates as desired. This is especially advantageous for the integration of microstructures and substrates made of incompatible material systems, e.g. GaAs on Si. Microstructures can be fabricated densely packed on the substrate prior to freeing, and the fluid containing them can be recycled to minimize waste. Also, different types of devices can be simultaneously placed at different positions on the host substrates by using selective features that differentiate among devices features.
The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells (2006)

Choroid plexuses (CP) are involved in multiple functions related to their unique architecture and localization at the interface between the blood and cerebrospinal fluid compartments. These include the release by choroidal epithelial cells (CEC) of biologically active molecules, such as polypeptides, which are distributed globally to the brain. Here, we have used a proteomic approach to get an unbiased overview of the proteins that are secreted by primary cultures enriched in epithelial cells from mice CP. We identified a total of 43 proteins secreted through the classical vesicular pathway in CEC -conditioned medium. They include transport proteins, collagen subunits and other cell matrix proteins, proteases, protease inhibitors and neurotrophic factors. Treating CEC cultures with lipopolysaccharide, increased the secretion of four protein species and induced the release of two additional proteins. Our study also reveals a higher protein secretion capacity of CECs compared with other CP cells or cultured astrocytes. In conclusion, this study provides for the first time the characterization of the major proteins that are secreted by CECs. These proteins may play a critical role in neuronal growth, differentiation and function as well as in brain pathologies.
A reverse pendulum bath cryostat design suitable for low temperature scanning probe microscopy (2005)

A new low temperature, ultrahigh vacuum cryostat design has been developed for atomic force and scanning tunnelling microscopy measurements. A microscope can be operated at 5 K in ultrahigh vacuum. The microscope body is thermally connected to a reverse pendulum and completely surrounded by a radiation shield. The design allows in situ dosing and irradiation of the sample as well as for easy access of tip and sample. The temperature performance and the vibrational properties of the reverse pendulum design are demonstrated in detail. A brief overview of low temperature instrumentation in scanning probe microscopy is given.
ChemInform Abstract: Diels‐Alder Reactions of 3‐(2‐Nitrovinyl)indoles: Formation of Carbazoles and Bridged Carbazoles. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Osteochondroma of the cervical spine causing cord compression: A case report. (1984)

Involvement of the spinal cord from a vertebral osteochondroma is indeed rare. We have reported the clinical, roentgenographic, and operative findings of an osteochondroma arising from the lamina of the 5th cervical vertebra. Severe neurological deficits were largely relieved by excision of the osteochondroma.
ChemInform Abstract: 1,2‐cis‐β‐Mannopyranoside Formation by the Dimethylphosphinothioate Method. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamical studies of the ferroelectric domain structure in triglycine sulfate by voltage-modulated scanning force microscopy (2000)

Voltage-modulated scanning force microscopy has been employed to investigate the dynamics of ferroelectric domains as a function of time and temperature in triglycine sulfate (TGS) single crystals. Branching of the domain structure and nucleation of fine domain patterns by internal fields of thermal origin have been directly observed on the submicron scale. Domain coarsening after quenching TGS samples from the paraelectric phase into the ferroelectric one has been studied, revealing a nonlinear time dependence of the characteristic correlation domain length and supporting the validity of dynamical scaling law and the conservation of the total surface charge. Substantial differences in the evolution of the domain structure have been detected during cooling or heating treatment in the ferroelectric phase. Domain contrast is shown to monitor the ferroelectric phase transition through its temperature dependence, reflecting the competition between electrostatic and piezoelectric effects.
Cost-effectiveness Analysis of a Rotavirus Immunization Program for the United States (1995)

Economic and disease reduction benefits would be realized from the use of an RV vaccine that is partially protective against severe RV diarrhea. These findings suggest that immunization with an RV vaccine would be cost effective and cost saving.
An MD-study on changing the elemental distribution and composition by alloying to control front propagation in Al–Ni multilayers (2022)

To cover the wide range of applications of reactive multilayers, it is necessary to have the ability to vary and control their front propagation velocities as well as their maximum reaction temperatures. In this paper, Molecular Dynamics simulations are used to study the influence of Al alloying, Ni alloying, and Co alloying on Al–Ni multilayers. In the case of alloying with Al and Ni, the iso-stoichiometric case where both the Al and the Ni layers are alloyed is first studied. In the second step, the stoichiometry is varied by alloying only one of the two layers with the other element. This allows for achieving very small front propagation velocities. Furthermore, the Ni layer is alloyed with Co and the whole range from a binary Al–Ni to the binary Al–Co system is studied. The front propagation velocity does not change linearly with the alloying fraction and reaches a minimum where the Ni/Co alloy changes from a face centered cubic to a hexagonal close packed lattice.
In Vitro Effects of Glucocorticoid on Glucose Transport in Rat Adipocytes: Evidence of a Post-Receptor Coupling Defect in Insulin Action1 (1984)

The in vitro effect of glucocorticoid on insulin binding and glucose transport was studied with rat adipocytes. Isolated rat adipocytes were incubated with or without 0.70 microgram/ml (1.9 mumol) of hydrocortisone in TCM 199 medium at 37 degrees C, 5% CO2/95% air (v/v), pH 7.4, for 2, 4, and 8 h, and then fat cell insulin binding and insulin-stimulated 3-O-methylglucose transport were measured. Hydrocortisone did not affect insulin binding in terms of affinity or receptor number. Glucose transport in the absence of insulin was significantly decreased at the incubation time of 2 h and continued to decrease up to 8 h of incubation with hydrocortisone. Decreased insulin sensitivity of glucose transport (i.e., a right-ward shift of the dose response curve) was also demonstrated after 2 h incubation with hydrocortisone, and the ED50 of insulin was maximally increased at 4 h of incubation (0.53 ng/ml for treated vs. 0.22 ng/ml for control cells). Maximal insulin responsiveness was also significantly decreased in treated cells after 8 h incubation with hydrocortisone. When percent maximum glucose transport was expressed relative to receptor-bound insulin, the ED50 values of treated and control cells were 10.5 and 7.2 pg of bound insulin, per 2 X 10(5) cells, respectively. Thus, it was evident that glucocorticoid induced a post-receptor coupling defect in the signal transmission of insulin-receptor complex.
MILTON AND SIERRA LEONE (1966)

MILTON AND SIERRA LEONE Get access P. E. H. HAIR P. E. H. HAIR University of Khartoum Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 13, Issue 1, January 1966, Pages 23–24, https://doi.org/10.1093/nq/13-1-23 Published: 01 January 1966
Thermodynamic Contribution of Amino Acids in Ionic Liquids Towards Protein Stability (2014)

Amino acids (AAs) combine to form a three-dimensional protein structure and are of very much importance in understanding the biophysical properties of biomolecules. Basically, the nature and the arrangement of the AAs in a protein backbone is only responsible for the individual characteristics of the macromolecule. The AAs in a protein backbone are influenced by the solvent molecules hence, it is very important to have a clear idea on the solubility, stability, and thermodynamic properties of these AAs in various solvents and co-solvents. A basic level of quantifying protein-solvent interactions involve the use of transfer free energies, ΔGtr from water to solvents. The values of ΔGtr for side chains and peptide backbone quantify the thermodynamic consequences of solvating a protein species in a co-solvent solution relative to pure water. Based on the transfer model and experimental ΔGtr for these AAs, it has been proposed that these cosolvents exert their effect on protein stability primarily via the protein backbone. The ΔGtr of AAs from water to another solvent system will be either favorable or unfavorable. By definition, an unfavorable transfer free energy, ΔGtr > 0, means that the protein becomes solvophobic on transfer to a solvent, whereas a favorable transfer free energy, ΔGtr < 0, represents that the protein becomes solvophilic on transfer to a solvent. The sign and magnitude of the measured ΔGtr quantifies the protein response to changes in solvent quality. Therefore, this review will provide the basis of a universal mechanism for co-solvent-mediated (that includes the new novel biocompatible ionic liquids (ILs)) protein stabilization and destabilization as the protein backbone is shared by all proteins, regardless of side chain sequence. Keywords: Amino acids, free energy, ionic liquids, molecular dynamics, protein stability, thermodynamics.
Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations (2015)

RNA polymerase (RNAP) performs various tasks during transcription by changing its conformational states, which are gradually becoming clarified. A recent study focusing on the conformational transition of RNAP between the ratcheted and tight forms illuminated the structural principles underlying its functional operations.
Principles of Operation for Shingled Disk Devices (2011)

A leading strategy for driving the areal density of magnetic disk drives through 1 – 10 terabit/inch 2 (the coming decade) is to shingle (partially overlap) adjacent tracks, imposing significant restrictions on where data can be written without incurring multi-track read-modify-write penalties. These restrictions and penalties can be 1) fully hidden from system software using techniques familiar in NAND Flash disks; 2) minimally exposed as multi-track, shingled bands of predetermined size that can be read normally, but only appended to or trimmed (erased); or 3) maximally exposed as dynamically sized bands of shingles separated by guard regions of previously erased tracks, allowing maximal capacity to be obtained by the most sophisticated system software. While the latter options require significant changes in system software, there is a rich history of demonstrations of log-structured file systems that should be able to do this, and a profusion of write-once cloud storage systems that could provide the economic “killer application ” [Kleiman11]. Now is a very good time for systems software experts to take interest and weigh in as magnetic disk technologists are experimenting and prototyping shingled disks. Experience shows that changes in the interface model for magnetic disks can take decades to change (for example, 512B to 4096B sectors) unless device vendors and systems software developers work together toward mutually desired principles of operation.
Wound Complication in Post‐chemoradiotherapy Neck Dissection (2011)

Objective Report the incidence and type of postoperative complications following neck dissection in patients with advanced stage squamous cell cancer of the laryngopharynx treated with chemoradiotherapy (CRT) and to identify factors predictive of these complications. Method Design: Retrospective review of case series. Setting: Single institution. Patients: Thirty‐three patients with advanced laryngopharyngeal cancer who underwent postchemoradiation neck dissection between 2003 and 2007 were identified. Intervention: Neck dissection, with or without resection of the primary site, in patients following chemoradiotherapy. Main outcome measure: postoperative complications. Results Thirty‐eight neck dissections were carried out in 33 patients (median ± SD age, 59 ± 7.8 years; 85% male). Local wound complications were recorded in 6 (18%) of 33 patients with one mortality from carotid rupture. Complications were seen in 1 (17%) of 6 patients with N1 disease, 5 (23%) of 22 patients with N2, and 0 of 5 patients with N3 neck disease. There was no association between type of neck dissection, medical comorbidities, smoking, time interval between completion of chemoradiotherapy and neck dissection, and rate of complications ( P &gt;. 05). There were no recorded systemic complications following salvage surgery. Conclusion The incidence of wound complications after neck dissection in patients treated with chemoradiation in our cohort is 18%. This compares favorably to reported literature. Nutritional issues and patients’ co‐morbidities should be addressed to minimize wound complications risk.
Parameter Estimation for Real Filtered Sinusoids (1997)

Abstract : This research develops theoretical methods for parameter estimation of filtered, pulsed sinusoids in noise and demonstrates their effectiveness for Electronic Warfare (EW) applications. Within the context of stochastic modeling, a new linear model, parameterized by a set of Linear Prediction (LP) coefficients, is derived for estimating the frequencies of filtered sinusoids. This model is an improvement over previous modeling techniques since the effects of the filter and the coefficients upon the noise statistics are properly accounted for during model development. From this linear model, a relationship between LP coefficient estimation and Maximum Likelihood (ML) frequency estimation is derived and several coefficient estimators, based on fixed point theory and ML techniques, are constructed. A bound for the coefficient estimation error is developed and used to gauge the quality of point estimates directly from the data and knowledge of the noise variance. Furthermore, a multirate implementation of an EW digital channelized receiver is described functionally and probabilistically. When applied to the EW receiver, simulations indicate the new estimators provide unbiased, minimum variance, parameter estimates of filtered sinusoids at lower SNRs than the estimators currently employed. The bounds on the estimation error are then used establish confidence intervals for each point estimate.
Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds (2015)

Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer. Prenyltransferases are essential players in terpenoid and hybrid isoprenoid biosynthesis that install isoprene units on target molecules and thereby often modulate their bioactivity. In our search for new prenyltransferase biocatalysts we focused on the marine-derived Streptomyces sp. CNQ-509, a particularly rich source of meroterpenoid chemistry. Sequencing and analysis of the genome of Streptomyces sp. CNQ-509 revealed seven putative phenol/phenazine-specific ABBA prenyltransferases, and one putative indole-specific ABBA prenyltransferase. To elucidate the substrate specificity of the ABBA prenyltransferases and to learn about their role in secondary metabolism, CnqP1 -CnqP8 were produced in Escherichia coli and incubated with various aromatic and isoprenoid substrates. Five of the eight prenyltransferases displayed enzymatic activity. The efficient conversion of dihydroxynaphthalene derivatives by CnqP3 (encoded by AA958_24325) and the co-location of AA958_24325 with genes characteristic for the biosynthesis of THN (tetrahydroxynaphthalene)-derived natural products indicates that the enzyme is involved in the formation of debromomarinone or other naphthoquinone-derived meroterpenoids. Moreover, CnqP3 showed high flexibility towards a range of aromatic and isoprenoid substrates and thus represents an interesting new tool for biocatalytic applications.
Field Monitoring for Insecticide Resistance in Beet Armyworm (Lepidoptera: Noctuidae) (1989)

Journal Article Field Monitoring for Insecticide Resistance in Beet Armyworm (Lepidoptera: Noctuidae) Get access Michael J. Brewer, Michael J. Brewer Department of Entomology, University of California, Riverside, California 92521 Search for other works by this author on: Oxford Academic PubMed Google Scholar John T. Trumble John T. Trumble Department of Entomology, University of California, Riverside, California 92521 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 82, Issue 6, 1 December 1989, Pages 1520–1526, https://doi.org/10.1093/jee/82.6.1520 Published: 01 December 1989 Article history Received: 26 April 1988 Accepted: 06 January 1989 Published: 01 December 1989
NSDMiner: Automated discovery of Network Service Dependencies (2012)

Enterprise networks today host a wide variety of network services, which often depend on each other to provide and support network-based services and applications. Understanding such dependencies is essential for maintaining the well-being of an enterprise network and its applications, particularly in the presence of network attacks and failures. In a typical enterprise network, which is complex and dynamic in configuration, it is non-trivial to identify all these services and their dependencies. Several techniques have been developed to learn such dependencies automatically. However, they are either too complex to fine tune or cluttered with false positives and/or false negatives. In this paper, we propose a suite of novel techniques and develop a new tool named NSDMiner (which stands for Mining for Network Service Dependencies) to automatically discover the dependencies between network services from passively collected network traffic. NSDMiner is non-intrusive; it does not require any modification of existing software, or injection of network packets. More importantly, NSDMiner achieves higher accuracy than previous network-based approaches. Our experimental evaluation, which uses network traffic collected from our campus network, shows that NSDMiner outperforms the two best existing solutions significantly.
Using principles of motor control to analyze performance of human machine interfaces (2023)

There have been significant advances in biosignal extraction techniques to drive external biomechatronic devices or to use as inputs to sophisticated human machine interfaces. The control signals are typically derived from biological signals such as myoelectric measurements made either from the surface of the skin or subcutaneously. Other biosignal sensing modalities are emerging. With improvements in sensing modalities and control algorithms, it is becoming possible to robustly control the target position of an end-effector. It remains largely unknown to what extent these improvements can lead to naturalistic human-like movement. In this paper, we sought to answer this question. We utilized a sensing paradigm called sonomyography based on continuous ultrasound imaging of forearm muscles. Unlike myoelectric control strategies which measure electrical activation and use the extracted signals to determine the velocity of an end-effector; sonomyography measures muscle deformation directly with ultrasound and uses the extracted signals to proportionally control the position of an end-effector. Previously, we showed that users were able to accurately and precisely perform a virtual target acquisition task using sonomyography. In this work, we investigate the time course of the control trajectories derived from sonomyography. We show that the time course of the sonomyography-derived trajectories that users take to reach virtual targets reflect the trajectories shown to be typical for kinematic characteristics observed in biological limbs. Specifically, during a target acquisition task, the velocity profiles followed a minimum jerk trajectory shown for point-to-point arm reaching movements, with similar time to target. In addition, the trajectories based on ultrasound imaging result in a systematic delay and scaling of peak movement velocity as the movement distance increased. We believe this is the first evaluation of similarities in control policies in coordinated movements in jointed limbs, and those based on position control signals extracted at the individual muscle level. These results have strong implications for the future development of control paradigms for assistive technologies.
Asymmetric Borane Reduction of Prochiral Ketones Using Aluminum Triethoxide and Chiral Amino Alcohols (1999)

Abstract The asymmetric borane reduction of prochiral ketones with catalysts prepared in situ from aluminum triethoxide and chiral amino alcohols was examined, and the corresponding chiral alcohols were obtained in high optical purity.
Single-axis solar tracker control with a solar position web service (2014)

This thesis presents an approach for the control of chronological solar trackers using web services in a Service Oriented Architecture. The approach is validated through the design and construction of a web service that provides solar position information for trackers, and the construction of a single-axis solar tracker that connects to the web service to determine how to orient itself. A number of different drive mechanisms are experimented with for the solar tracker, with the worm-gear motor proving to be the most appropriate.
Fluorescence polarization analysis of antigen determinant peptides of human fibrinogen. (1984)

Fluorescamine-labelled human fibrinogen was degraded with trypsin. Using fluorescence detection, the degradation products were fractionated by Sephadex G 50 gel filtration. Fragments of 3000-10 000 molecular weight were isolated for the fluorescence polarization studies. Specific antifibrinogen antibody increased the polarization of the isolated low molecular weight fragments. These results suggest that even the smallest proteolytic fragments of fibrinogen contain antigen determinant sequences. The fluorescence polarization method offers a sensitive and valuable approach for the analysis of the small antigenic peptides of human fibrinogen.