gebhart/patrepeval huggingface dataset:
An interactive control system for mobile robot based on cloud services (2018)

Summary Visual interaction is one of the most important ways for mobile robots to serve the elderly in the future. Mobile robots need to recognize human movements to follow human movements or evade actions. An indoor mobile robot interaction system based on cloud servers is presented. In a human‐machine coexistence environment, the mobile robot recognizes human motion, which represents the control intention for robot. In addition, if the person does not issue a control command, the robot follows the operator moving trajectory as a follower. A mobile robot with four Mecanum wheels is used in experiments. In the robot, a 3D camera is used to capture human motion and recognizes the language control commands. Then, the mobile robot executes the command action after translating the human body language to its motion direction control mode. Moreover, a 2D camera in the robot is used to autonomously capture 2D human multi‐view images and combines facial recognition to achieve specific human target to follow‐up. Some experiments are presented to verify the effectiveness of the whole Interaction control system.
trk and ret proto‐oncogene expression in human neuroblastoma specimens: High frequency of trk expression in non‐advanced stages (1993)

Forty-three fresh tumor specimens of human neuroblastoma belonging to different clinical stages were analyzed for the expression of 2 proto-oncogenes: trk, which encodes a tyrosine-kinase receptor for nerve growth factor (NGF) and ret, another receptor-type tyrosine kinase whose ligand is unknown. The mRNA expression of the trk gene was detected in 67.4% of cases, with increased frequency in I, II and IVs Evans' stages and in patients with favorable prognosis according to the Shimada classification. Moreover, trk expression inversely correlated with Nmyc-gene amplification. ret mRNA was found in 36.8% of cases and equally distributed in the different stages. In addition, ngfR (low-affinity NGF receptor)-gene expression was present in 9 out of 25 cases. The simultaneous presence of mRNA related to both forms of the NGF receptor, while not proving the presence of a functional receptor, indicates the existence of a sub-set of neuroblastoma cells potentially responsive to NGF.
Temporal- and spectral-property measurements of narrowband photon pairs from warm double-Λ-type atomic ensemble (2020)

We investigate the temporal and spectral properties of narrowband photon pairs from a double-Λ-type atomic system of a warm <sup>87</sup>Rb atomic ensemble. The temporal properties of the narrowband photons are investigated by measuring their auto-correlation and cross-correlation functions. The spectral measurement of the photon pair is obtained by applying the stimulated emission method. We show that the biphoton spectral waveform with a spectral width of ∼6 MHz corresponds to the biphoton temporal waveform with a temporal width of ∼26 ns. We believe that our results can contribute to the characterization of narrowband photons generated from atomic ensembles and aid in the development of new photonic quantum states generated from atomic systems.
A massively parallel approach to real-time vision-based road markings detection (2002)

This paper presents the vision-based road detection system currently operative onto the MOB-LAB land vehicle. Based on a full-custom low-cost massively parallel system, it achieves real-time performances (/spl sime/17 Hz) in the processing of image sequences, due to the extremely efficient implementation of the algorithm. Assuming a flat road and the complete set of acquisition parameters are known (camera position, orientation, optics), the system is capable to detect road markings on structured roads even in extremely severe shadow conditions.
Amide-Linked Monocarbonyl Curcumin Analogues: Efficient Synthesis, Antitubercular Activity and Molecular Docking Study (2020)

An approach toward the synthesis of novel conjugates of 3,5-bis (arylidene)-4-piperidones (DAP) pharmacophore with amide-linkage has been developed via one-pot multicomponent reaction of aryl aldehydes, piperidinone and 2-chloro-N-phenylacetamide using [Et3NH][HSO4] as a catalyst/medium. Both substitutions on arylidene rings and piperidinone nitrogen (substituted 2-chloro-N-phenylacetamide) were varied. The synthesized conjugates were evaluated for their in vitro antitubercular activity against M. tuberculosis H37Ra (MTB) and M. bovis BCG strains. Among the series, compounds 4f, 4g, 4i and 4j showed remarkable broad spectrum antitubercular activity with low IC50 values. Furthermore, computer docking simulations, for the most active conjugates were performed with the active site of mycobacterial enoyl-acyl carrier protein reductase (InhA) support the antitubercular activity. Lower cytotoxicity, high potency and promising activity against MTB and M. Bovis BCG suggest that amide linked DAP could serve as good leads for further modifications and development.
Indium‐free violet LEDs grown by HVPE (2003)

We report on first demonstration of violet light emitting diodes (LED) based on AlGaN/GaN/AlGaN heterostructures grown by hydride vapor phase epitaxy (HVPE). The unique aspects of this technological approach are (i) growth of Al-containing epitaxial material by HVPE and (ii) use of HVPE to fabricate submicron multi-layer epitaxial structures. The LEDs provide light emission at the wavelength of 415–420 nm that did not shift with forward current. External efficiency up to 2.5% is reached at the current of 20 mA. The brightness of LED lamp is as high as 400–500 mcd. This suggests HVPE as an alternative technique for growing AlGaN-based LED structures. Results of the LED modeling and characterization are discussed. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Authenticated encryption scheme based on quadraticresidue (1998)

The Rabin public-key scheme is based on the difficulty of finding square roots modulo a composite number. The author combines Rabin&apos;s encryption with Rabin&apos;s signature, and presents a new authenticated message encryption scheme based on the quadratic residue problem which can be realised efficiently and has lower communication costs.
Abstract 2082: Obesity dependent benefits of metformin for improved anti-tumor immunity and outcomes in non-small cell lung cancer (2022)

Abstract Metformin, the widely used and studied diabetes drug, has been reported to have anti-cancer effects. However, in retrospective clinical studies, the survival benefit associated with metformin use in cancer patients is often modest. Consequently, the design and conduct of sufficiently powered prospective clinical trials aimed at exploring this drug’s anti-tumor potential are hampered by the absence of predictive biomarkers. Testing the notion that specific patient characteristics such as obesity may impact the relative potency of metformin’s effects on lung cancer survival, we analyzed the patient outcomes of 756 non-small cell lung cancer (NSCLC) cases with early- (stage I/II, n = 490) or late-stage disease (stage III/IV, n = 266) that either did or did not use metformin (n = 121 and 635, respectively) while not receiving neoadjuvant therapy. We found that metformin use is associated with improved overall and recurrence free survival only in overweight and obese patients defined by a body mass index (BMI) greater than 25 kg/m2. Corroborative findings obtained from immunocompetent mouse lung cancer models aligned with these observations. In these studies, despite supporting accelerated growth of both primary and metastatic tumors compared to their normal weight counterparts, animals subjected to diet induced obesity (DIO) experienced significantly reduced tumor development upon metformin treatment. In contrast, the drug had little-to-no effect on tumor burden in normal weight controls. Furthermore, while flow cytometric evaluation of obese mouse-derived tumors identified several previously described mediators of immune dysfunction previously described in animals with DIO (e.g., widespread up-regulation of the immune checkpoint factors PD-1 and Lag3, elevated suppressor cell proportions and activity), metformin treatment was associated with their reversal specifically in the tumors of obese mice. Interestingly, the drug had little effect on the tumor immune contexture of normal weight mice, and gene expression analysis failed to reveal considerable alterations in canonical cancer pathways. Thus, our preclinical and clinical studies suggest that the anti-diabetic drug metformin has an anti-cancer effect in NSCLC that is restricted to overweight individuals and reflects its potential to direct favorable, context-specific immune reprogramming. This work also provides the rationale for using high BMI as a predictive biomarker of the anti-cancer effect of metformin in lung cancer. Citation Format: Joseph Barbi, Randall J. Smith, Robert Zollo, Stephanie N. Sass, Deschana Washington, Cara Petrucci, Aravind Srinivasan, Eric Kannisto, Santosh Patnaik, Sai Sai Yendamuri. Obesity dependent benefits of metformin for improved anti-tumor immunity and outcomes in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2082.
Effects of hyperthermia on the intracellular pH and membrane potential of Chinese hamster ovary cells (1989)

The effects of hyperthermia (exposure to 41-47 degrees C) on the intracellular pH and membrane potential have been studied using Chinese hamster ovary HA-1 cells. Our goal was to determine whether intracellular pH changes or changes in membrane potential correlated with cell killing. The intracellular pH (pHi) was measured using the DMO partitioning technique. A rapid acidification of the intracellular environment was observed at all the elevated temperatures studied. The pHi reached a plateau value of approximately 6.9, and started reversing towards normal values upon prolonged exposure to heat. Similar patterns were seen for delta pH (pHi-pHo). The membrane potential difference (delta psi) was measured using the fluorescence quenching of 3,3-dipropylthio-carbocyanine, and calibrated using a 86Rb+ diffusion potential. We found that delta psi falls to zero only upon prolonged exposure to temperatures above 43 degrees C. When the external pH was changed from normal values the drop in delta psi occurred more readily. Development of thermotolerance resulted in an increase in the time required to make delta psi change by half. The changes in delta psi were shown to be irreversible. When the proton electrochemical gradient (delta mu H+) was calculated using the measured values of delta psi and delta pH, the trends observed were the same as those seen for delta psi. The changes observed for pHi can be accounted for by the changes in the pK values of the components involved in the intracellular buffering. The changes in delta psi and delta mu H+ may reflect the physical breakdown of the transmembrane H+ gradients, which may be the actual mechanical process of cell death. No correlation of cell survival with the measured parameters was observed.
A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases (2016)

The ability to control enzymatic nicotinamide cofactor utilization is critical for engineering efficient metabolic pathways. However, the complex interactions that determine cofactor-binding preference render this engineering particularly challenging. Physics-based models have been insufficiently accurate and blind directed evolution methods too inefficient to be widely adopted. Building on a comprehensive survey of previous studies and our own prior engineering successes, we present a structure-guided, semirational strategy for reversing enzymatic nicotinamide cofactor specificity. This heuristic-based approach leverages the diversity and sensitivity of catalytically productive cofactor binding geometries to limit the problem to an experimentally tractable scale. We demonstrate the efficacy of this strategy by inverting the cofactor specificity of four structurally diverse NADP-dependent enzymes: glyoxylate reductase, cinnamyl alcohol dehydrogenase, xylose reductase, and iron-containing alcohol dehydrogenase. The analytical components of this approach have been fully automated and are available in the form of an easy-to-use web tool: Cofactor Specificity Reversal-Structural Analysis and Library Design (CSR-SALAD).
Byzantium in Western Chronicles before the First Crusade (2017)

Modern writers have seen the First Crusade as marking a turning-point in relations between Catholic Christendom and the Byzantine empire. It has to be recognized that many western chronicles of the twelfth century do express hostile attitudes to Byzantium, especially in connection with their accounts of the First Crusade. The anonymous author of the Gesta Francorum was deeply hostile to Byzantium. The crucial part of the Gesta in respect of attitudes to Byzantium concerns the scene at Philomelium. In the Gesta, this is a highly dramatic scene in which Guy, Bohemond's half-brother who was in Byzantine service, pleads for the emperor to go to relieve the crusaders in Antioch. In practice, the German chronicles mention Byzantium very rarely, and almost always to record occasions when Byzantine diplomats made contact with the imperial court. The tone is only occasionally hostile, but the most obvious factor is that they deny the title of 'Roman emperor' to the ruler at Constantinople.
In vivo brain GPCR signaling elucidated by phosphoproteomics (2018)

A systems view of G protein-coupled receptor (GPCR) signaling in its native environment is central to the development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR) as a model, we employed high-throughput phosphoproteomics to investigate signaling induced by structurally diverse agonists in five mouse brain regions. Quantification of 50,000 different phosphosites provided a systems view of KOR in vivo signaling, revealing novel mechanisms of drug action. Thus, we discovered enrichment of the mechanistic target of rapamycin (mTOR) pathway by U-50,488H, an agonist causing aversion, which is a typical KOR-mediated side effect. Consequently, mTOR inhibition during KOR activation abolished aversion while preserving beneficial antinociceptive and anticonvulsant effects. Our results establish high-throughput phosphoproteomics as a general strategy to investigate GPCR in vivo signaling, enabling prediction and modulation of behavioral outcomes.
Performance characteristics and average-value modeling of auxiliary resonant commutated pole converter based induction motor drives (1999)

The auxiliary resonant commutated pole (ARCP) power converter is currently of intense interest for use in a variety of power electronic converters, and is one of the cornerstones of the US Navy's power electronic building block (PEBB) effort. In this paper, a detailed discussion of the required switching times needed to achieve completely soft switching operation with only one current sensor per phase is set forth. Based on this analysis, an average-value model of the ARCP converter is derived and used to explore its output characteristics. It is shown that large loads at high power factors can cause the ARCP output voltage to drop substantially. Computer simulations and laboratory data are used to validate this analysis.
Neuere Methoden der präparativen organischen Chemie VI Synthesen von Isocyanaten und Carbodiimiden (1966)

Durch Reaktion 1,3-disubstituierter Harnstoffe und 1-Arylsulfonyl-3-alkylharnstoffe mit Phosgen kann eine Anzahl bisher nicht beschriebener oder schwer zugänglicher Isocyanate und Sulfonylisocyanate dargestellt werden. Aus 1,3-disubstituierten Thioharnstoffen und 1-Aryl(oder Alkyl)sulfonyl-3-alkylthioharnstoffen erhält man Carbodiimide. Thionylchlorid und Phosphorpentachlorid reagieren mit den Harnstoffderivaten nach den gleichen Gesetzmäßigkeiten wie Phosgen. Oxalylchlorid setzt sich mit Harnstoffen unter Bildung von Parabansäurederivaten um, während es mit Thioharnstoffen 2-Imino-1,3-thiazolidinhyphen;4,5-dione liefert, die zu Thioparabansäurederivaten isomerisieren können.
Screening for Clostridioides difficile colonization at admission to the hospital: a multi-centre study (2023)

In this endemic setting with a low prevalence of 'hypervirulent' strains, screening for CDC at admission did not detect any patients with CDC who progressed to symptomatic CDI and detected only one possible transmission event from a patient with colonization to a patient with CDI. Thus, screening for CDC at admission is not useful in this setting.
Inactivation of Serpulina hyodysenteriae flaA1 and flaB1 periplasmic flagellar genes by electroporation-mediated allelic exchange (1995)

Serpulina hyodysenteriae, the etiologic agent of swine dysentery, contains complex periplasmic flagella which are composed of multiple class A and class B polypeptides. To examine the role these proteins play in flagellar synthesis, structure, and function and to develop strains which may provide insight into the importance of motility in the etiology of this pathogen, we constructed specific periplasmic flagellar mutations in S. hyodysenteriae B204. The cloned flaA1 and flaB1 genes were disrupted by replacement of internal fragments with chloramphenicol and/or kanamycin gene cassettes. Following delivery of these suicide plasmids into S. hyodysenteriae, homologous recombination and allelic exchange at the targeted chromosomal flaA1 and flaB1 genes was verified by PCR, sequence, and Southern analysis. The utility of a chloramphenicol resistance gene cassette for targeted gene disruption was demonstrated and found more amenable than kanamycin as a selective marker in S. hyodysenteriae. Immunoblots of cell lysates of the flagellar mutants with antiserum raised against purified FlaA or FlaB confirmed the absence of the corresponding sheath or core protein. Both mutations selectively abolished expression of the targeted gene without affecting synthesis of the other flagellar polypeptide. flaA1 and flaB1 mutant strains exhibited altered motility in vitro and were less efficient in movement through a liquid medium. Paradoxically, isogenic strains containing specifically disrupted flaA1 or flaB1 alleles were capable of assembling periplasmic flagella that were morphologically normal as evidenced by electron microscopy. This is the first report of specific inactivation of a motility-associated gene in spirochetes.
The Visualization of Flow Patterns on a Sphere in a Packed Bed [Translated]<sup>†</sup> (1987)

An experiment was made to visualize the surface flow pattern of spheres in a packed bed. Spheres, the surface of which were coated with benzoic acid, were set within a packed bed and exposed to water flow for a certain period of time. The flow patterns on the surface were observed by the patterns of dissolution of benzoic acid. The patterns were compared with the results of visualizations by other workers using a different method. It was found that the present results are in good agreement with those results in terms of the location of separation lines and singular points on the surface.† This report was originally printed in J. Soc. Powder Technology, Japan, 22(9), 599-605 (1985) in Japanese, before being translated into English by KONA Editorial Committee with the permission of the editorial committee of the Soc. Powder Technology, Japan.
Fast centralized authentication in Wi-Fi HaLow networks (2017)

In early 2016 Wi-Fi Alliance announced a new technology - Wi-Fi HaLow - which aims to master the raising Internet of Things market with its tremendous number of devices. This technology brings revolutionary changes to Wi-Fi, improving transmission reliability and power efficiency in scenarios with thousands of sensor stations being connected to a single access point. However neither novel channel access methods, nor advanced power management schemes can be used until the stations are connected to the access point, because the access point may not know that the stations exist, to say nothing about their capabilities. Nevertheless, it may happen that a large group of sensor stations are simultaneously trying to connect to the access point, which inevitably leads to continuous collisions and finally to extremely long connection process. This problem has been addressed by the technology developers which designed the Centralized Authentication Control protocol. The protocol provides the access point with an opportunity to hasten the process by managing the ratio of stations which are allowed to start establishing a connection. In this paper, we study how the number of successes depends on this ratio and develop two algorithms, which hasten connection process close to the theoretical limit.
Natural Killer Cell Activity and Resistance to Tumor Metastasis in Prepubescent Rats: Deficient Baselines, but Invulnerability to Stress and β-Adrenergic Stimulation (2000)

Although young children and animals exhibit high rates of tumor development, little is known about natural killer (NK) cell activity in the very young. We recently provided direct evidence that reduced levels of NK activity in prepubescent rats underlie higher levels of susceptibility to metastasis. The aim of the current study was to further characterize NK activity and tumor resistance in prepubescent rats, specifically with respect to the effects of stress and sex, as these factors have been shown to modulate tumor development in adult populations. Two NK outcomes were assessed: levels of whole blood NK cytotoxicity and lung tumor retention of NK-sensitive MADB106 tumor cells which metastasize only to the lungs. The corticosterone (CS) response to surgery was also assessed. In the first set of experiments, prepubescent males and females (36 days of age) and mature males (98 days) were subjected to abdominal surgery and 5 h later were either tested for plasma CS levels or challenged with MADB106 tumor cells. The findings indicated that whereas surgery increased CS levels in the young rats to similar levels observed in mature animals, surgical stress did not increase lung tumor retention in the young animals, despite exerting marked and significant effects in the mature rats. These findings persisted when lower tumor loads were used in the young rats to compensate for the markedly reduced resistance to metastasis in this population. Because surgery involves activation of the sympathetic nervous system (SNS) which is known to regulate NK activity, we assessed the impact of the beta-adrenergic agonist, metaproterenol, on NK activity and on lung tumor retention. Metaproterenol (0.8 mg/kg, 1 h before testing) resulted in a large suppression of NK activity and resistance against MADB106 metastasis in mature males and females, but not in prepubescent animals. In mature, but not in young animals, males exhibited higher baseline levels of NK activity. Taken together, these findings indicate that NK cells of prepubescent rats are resistant to beta-adrenergic stimulation, and suggest that prepubescent rats are markedly less responsive to SNS-induced suppression of NK activity, which may underlie their invulnerability to the effects of surgery on MADB106 metastasis.
Localizing 3D cuboids in single-view images (2012)

In this paper we seek to detect rectangular cuboids and localize their corners in uncalibrated single-view images depicting everyday scenes. In contrast to recent approaches that rely on detecting vanishing points of the scene and grouping line segments to form cuboids, we build a discriminative parts-based detector that models the appearance of the cuboid corners and internal edges while enforcing consistency to a 3D cuboid model. Our model copes with different 3D viewpoints and aspect ratios and is able to detect cuboids across many different object categories. We introduce a database of images with cuboid annotations that spans a variety of indoor and outdoor scenes and show qualitative and quantitative results on our collected database. Our model out-performs baseline detectors that use 2D constraints alone on the task of localizing cuboid corners. 1