gebhart/patrepeval huggingface dataset:
Reciprocal Human Dendritic Cell–Natural Killer Cell Interactions Induce Antitumor Activity Following Tumor Cell Infection by Oncolytic Reovirus (2009)

Oncolytic virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated tumor regression. Although the ability of oncolytic viruses to generate adaptive antitumor immunity has been characterized, their interactions with the innate immune system are relatively unclear. Using a human in vitro system, this study investigates the innate immunological consequences of reovirus therapy and its potential to activate NK cell-mediated antitumor activity. Dendritic cells (DC) loaded with reovirus-infected human melanoma Mel888 cells (DC-MelReo), but not reovirus-infected tumor cells alone, induced IFN-gamma production within the NK cell population upon coculture with PBMC, in a cell-to-cell contact-dependent manner. DC-MelReo secreted the chemokines CCL2, 3, 4, 5, 7, 8, 11, and CXCL10; these culture supernatants induced NK cell chemotaxis. Coculture of DC-MelReo with purified NK cells induced reciprocal contact-dependent phenotypic DC maturation, while DC-MelReo elicited up-regulation of the activation marker CD69 on NK cells, in a partially contact and partially IL-12 dependent manner. Significantly, DC-MelReo induced NK cell cytotoxicity toward tumor cells by a type I IFN dependent mechanism. These data demonstrate that tumor infection by reovirus can act via DC to induce NK cell recruitment, activation, and cytotoxicity, along with reciprocal DC maturation. These findings suggest that reciprocal DC-NK cell interactions, following reovirus therapy, may play an important role in altering the immune milieu of the tumor microenvironment and mediating tumor regression.
Comment on "Investigation of scandate cathodes: emission, fabrication, and activation processes" by J.W. Gibson et al (1990)

Critical comments are made on the experimental results for zero field current density j/sub 0/ and work function obtained by J.W. Gibson et al. (ibid., vol.36, no.1, p.209-14, 1989) on top-layer scandate cathodes and on an emission model proposed for them. It is shown, for example, that the determination of j/sub 0/ gives rise to erroneous results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structure property relationships of carbonaceous films grown under ion enhancement (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. Weissmantel, E. Ackermann, K. Bewilogua, G. Hecht, H. Kupfer, B. Rau; Structure property relationships of carbonaceous films grown under ion enhancement. J. Vac. Sci. Technol. A 1 November 1986; 4 (6): 2892–2899. https://doi.org/10.1116/1.573654 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Performance boost for primary magnesium cells using iron complexing agents as electrolyte additives (2018)

Aqueous Mg battery technology holds significant appeal, owing to the availability of raw materials, high power densities and the possibility of fast mechanical recharge. However, Mg batteries have so far been prone to decreased capacity due to self-corrosion of the anodes from the electrochemical redeposition of impurities, such as Fe, which results in parasitic cathodically active sites on the discharging anode. This work demonstrates that by adding Fe<sup>3+</sup>-complexing agents like Tiron or salicylate to the aqueous electrolyte of an Mg battery, it was possible to prevent the redeposition of Fe impurities and subsequent self-corrosion of the anode surface, thereby boosting battery performance. To prevent detrimental fouling of anode surface by Mg(OH)<sub>2</sub>, employed Fe<sup>3+</sup>-complexing agents must also form soluble complexes with Mg<sup>2+</sup> of moderate stability. The interplay of these requirements predetermines the improvement of operating voltage and utilization efficiency.
Catalytic decomposition of acetylene on Fe(001): A first-principles study (2002)

The catalytic decomposition process in the initial stage of carbon nanotube (CNT) growth is investigated for the system of acetylene $({\mathrm{C}}_{2}{\mathrm{H}}_{2})$ on the Fe(001) surface through first-principles electronic structure calculation. In its most stable configuration, the C-C bond of ${\mathrm{C}}_{2}{\mathrm{H}}_{2}$ is lying on the hollow site along the [110] direction of the Fe(001) surface. The formation of the CH fragments accompanied by C-C bond breaking is found to be an intermediate step toward the full dissociation of ${\mathrm{C}}_{2}{\mathrm{H}}_{2}$ molecules on Fe(001) and the whole process is exothermic.
Analyse avec Iramuteq de dialogues en situation de négociation de crise : le cas Mohamed Mehra (2014)

International audience
Balancing networks for symmetric antennas .I. Classification and fundamental operation (2002)

Emphasis has been placed on the quality of a metrology antenna system that allows it to be represented accurately using analytical or numerical models. Central to this capability is the efficacy of the balancing networks, sometimes referred to as balanced to unbalanced transformers (baluns). In this paper, we classify three fundamental types of baluns and show that all three can be derived from the 180/spl deg/, four-port hybrid network. Balanced antennas driven from coaxial feed lines and operated in the presence of an asymmetric scatterer present an intrinsically unbalanced load to the balun. We show that in such situations the current balun is the only appropriate balun to employ. For numerous antenna metrology applications, in particular, site attenuation measurements, 180/spl deg/, four-port hybrid networks have been employed as baluns. Network relations are derived relating the so-called voltage and current baluns to the 180/spl deg/, four-port hybrid network. It is shown that, in addition to acting as a 0/spl deg/ or 180/spl deg/ power divider, the hybrid network can serve as either a voltage or a current balun depending on the termination at the isolated port. In contrast to the traditional approach, it is shown that when using a 180/spl deg/ hybrid as a balun, the isolated port should be terminated in such a way that the hybrid behaves as a current balun as opposed to a 180/spl deg/ power divider. This will yield experimental results that can be more readily reconciled with models.
Genome-Wide Association Study Suggests the Variant rs7551288*A within the DHCR24 Gene Is Associated with Poor Overall Survival in Melanoma Patients (2022)

Melanoma incidence rates are high among individuals with fair skin and multiple naevi. Established prognostic factors are tumour specific, and less is known about prognostic host factors. A total of 556 stage I to stage IV melanoma patients from Germany with phenotypic and disease-specific data were analysed; 64 of these patients died of melanoma after a median follow-up time of 8 years. Germline DNA was assessed by the HumanCoreExome BeadChip and data of 356,384 common polymorphisms distributed over all 23 chromosomes were used for a genome-wide analysis. A suggestive genome-wide significant association of the intronic allele rs7551288*A with diminished melanoma-specific survival was detected (<i>p</i> = 2 × 10<sup>-6</sup>). The frequency of rs7551288*A was 0.43 and was not associated with melanoma risk, hair and eye colour, tanning and total naevus count. Cox regression multivariate analyses revealed a 5.31-fold increased risk of melanoma-specific death for patients with the rs7551288 A/A genotype, independent of tumour thickness, ulceration and stage of disease at diagnoses. The variant rs7551288 belongs to the <i>DHCR24</i> gene, which encodes Seladin-1, an enzyme involved in the biosynthesis of cholesterol. Further investigations are needed to confirm this genetic variant as a novel prognostic biomarker and to explore whether specific treatment strategies for melanoma patients might be derived from it.
Formation of Li-Doped NiO and LiNiO2 in Molten Carbonate (1999)

Abstract The formations of Li-doped NiO and LiNiO2 in molten carbonate have been studied in CO2–O2 atmospheres from 761 to 1173 K by TGA, color change and XRD. After 24 h of immersion into a Li2CO3 or (Li0.62K0.38)2CO3 melt, the lithiation reaction of NiO was confirmed by both XRD and the color change of a specimen. The rate of the lithiation reaction was very slow, especially in a CO2-rich atmosphere. LiNiO2 was formed in an O2 atmosphere at higher temperatures. The temperature of LiNiO2formation in Li/K carbonate was higher than that in Li2CO3. Oxygen in the atmosphere would have an important role for the formation of LiNiO2 as well as the reaction temperature.
Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice (2016)

1.The expression of CLCX12 was significantly reduced, while the expression CXCR4 was greatly augmented (possibly via feedback cell reactionmechanism) in the WBMCs of the ApoA-I -/-compared to the WT mice.
The paraoxonases: role in human diseases and methodological difficulties in measurement (2009)

Research into the paraoxonase (PON) gene family has flourished over the past few years. In the 1970s and 1980s, only PON1 was known, and the investigations were conducted, essentially, by toxicologists focusing on protection against organophosphate poisoning. Since then, two new members of the family, PON2 and PON3, have been identified, both being shown to play antioxidant and anti-inflammatory roles. Evidence exists indicating that the PON family is central to a wide variety of human illnesses such as cardiovascular disease, diabetes mellitus, metabolic syndrome, obesity, non-alcoholic steatohepatitis, and several mental disorders. However, research is hampered considerably by the methods currently available to measure the activity of these enzymes. In this review, we summarize the state of knowledge on PON biochemistry and function, the influence of genetic variations, and the involvement of PON in several diseases. The problems associated with PON measurement, such as sample acquisition, lack of reference methods, and variety of substrates, will be presented. Also, we cover some of the present lines of research and propose some others for future progress in this field.
Effects of cavitation in the high intensity therapeutic ultrasound (2002)

Tissue destruction with high intensity ultrasound can be explained by the action of two effects: the first is a hyperthermic effect; the second involves physical damage to the cell from cavitation. In the study described, effects of cavitation were investigated as a function of intensity using either shock waves with large negative pulse or a 1-MHz focused field. In the first set of experiments the cavitation was strong enough to achieve focused and deep tissue destruction in the rabbit's liver. In the second set of experiments, it was shown that when cavitation was moderate no significant effect on tumor growth was achieved. It was thought that in these last experiments, the bubbles that appeared in the field strongly reduced the desired thermal effects of the radiation. It appears, then, that there is a set of optimal parameters that allows the best in vivo tumor treatment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Computational methods for drug target profiling and polypharmacology (2013)

The ‘magic bullet’ concept of hitting a target responsible for a disease with a drug molecule tailored to act as a selective agent, has been a therapeutic goal since the beginning of drug research and one of the driving forces in modern drug discovery for several decades. With the rise of structural biology and molecular pharmacology, and the shift from in vivo to in vitro models in the initial evaluation of biological effects of molecules, the aim of obtaining absolute target specificity had become a goal that seemed within reach. However, there is evidence that drugs interact with many physiological targets, and that polypharmacology bears essential importance on therapeutic efficacy. In this light, discovering compounds exhibiting the ‘right’ selectivity profile (i.e., interaction with several targets or target hubs in a converging biological pathway) has become the holy grail in drug development. Recent examples in the kinase field illustrate this new paradigm. Whereas imatinib (Gleevec®; Novartis, Switzerland) and sunitinib (Sutent®; Pfizer, NY, USA) were designed to be selective, later they were found to be more promiscuous than initially thought [1,2], which could explain why these molecules are successful therapeutically. As recently pointed out, searching for selectively nonselective kinase inhibitors when striking the right balance, can deliver candidates and drugs with superior efficacy compared with inhibitors with high specificity for a single kinase [3].
On some approaches to the autotuning of cascade controls (2008)

Some approaches to the autotuning of cascade controls are comparatively analysed, based on a conveniently characterised test batch. The reported analysis results is some remarks and possible guidelines for the design of cascade autotuners. It is worth noting that the presented simulation study considers the “identification experiment” as part of the autotuning procedure.
The neutron electric dipole moment experiment at the Spallation Neutron Source (2019)

Novel experimental techniques are required to make the next big leap in neutron electric dipole moment experimental sensitivity, both in terms of statistics and systematic error control. The nEDM experiment at the Spallation Neutron Source (nEDM@SNS) will implement the scheme of Golub & Lamoreaux [Phys. Rep., 237, 1 (1994)]. The unique properties of combining polarized ultracold neutrons, polarized 3He, and superfluid 4He will be exploited to provide a sensitivity to ∼ 10−28 e · cm. Our cryogenic apparatus will deploy two small (3 L) measurement cells with a high density of ultracold neutrons produced and spin analyzed in situ. The electric field strength, precession time, magnetic shielding, and detected UCN number will all be enhanced compared to previous room temperature Ramsey measurements. Our 3He co-magnetometer offers unique control of systematic effects, in particular the Bloch-Siegert induced false EDM. Furthermore, there will be two distinct measurement modes: free precession and dressed spin. This will provide an important self-check of our results. Following five years of “critical component demonstration,” our collaboration transitioned to a “large scale integration” phase in 2018. An overview of our measurement techniques, experimental design, and brief updates are described in these proceedings.
Automatic elimination of phase aberrations in digital holography based on Gaussian 1σ- criterion and histogram segmentation (2023)

We propose a numerical and automatic quadratic phase aberration elimination method in digital holography for phase-contrast imaging. A histogram segmentation method based on Gaussian 1σ-criterion is used to obtain the accurate coefficients of quadratic aberrations using the weighted least-squares algorithm. This method needs no manual intervention for specimen-free zone or prior parameters of optical components. We also propose a maximum-minimum-average-standard deviation (MMASD) metric to quantitatively evaluate the effectiveness of quadratic aberration elimination. Simulation and experimental results are demonstrated to verify the efficacy of our proposed method over the traditional least-squares algorithm.
Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes (2016)

Triple negative breast cancers (TNBCs), which are defined as estrogen-receptor, progesterone-receptor, and HER2-receptor negative, account for 10-20% of breast cancers, and they are associated with early metastasis, chemotherapeutic resistance, and poor survival rates. One aspect of TNBC that complicates its prognosis and the development of new molecular therapeutic targets is its clinical and molecular heterogeneity. Herein we compare TNBC and basal cytokeratin-positive breast cancers. We examine the different TNBC molecular subtypes, based on gene expression profiling, which include basal-like, mesenchymal, and luminal androgen receptors, in the context of their biology and impact on TNBC prognosis. We explore the potential role of inducible nitric oxide synthase (iNOS) in TNBC tumor biology and treatment responses. iNOS has been shown to induce p53 mutation accumulation, basal-like gene signature enrichment, and transactivation of the epidermal growth factor receptor (EGFR) via S-nitrosylation, all of which are key components of TNBC biology. Moreover, iNOS predicts poor outcome in TNBC, and iNOS inhibitors show efficacy against TNBC when used in combination with chemotherapy. We discuss molecular targeted approaches, including EGFR, PARP, and VEGF inhibitors and immunotherapeutics, that are under consideration for the treatment of TNBC and what role, if any, iNOS may play in their success.
Development and Implementation of an Extension IPM Program for Long Island (1987)

The insect component of an extension integrated pest management (IPM) program for fresh market potato production on Long Island, N.Y., was developed and implemented during 1981–1985. Sampling procedures and preliminary action thresholds for Colorado potato beetles (CPM), Leptinotarsa decemlineata (Say), were developed with data obtained in commercial potato fields during 1981–1983. The use of alternative CPB control procedures was promoted with on-farm demonstrations and by written and oral presentations. Sampling procedures and action thresholds for green peach aphids, Myzus persicae (Sulzer), and potato aphids, Macrosiphum euphorbiae (Thomas), were adopted from those used in potato IPM programs in upstate New York. Grower participation in the scouting program ranged from 8 growers with 130 hectares (ha) in 1982 to 22 growers with 411 ha in 1985. Evaluation of the Long Island potato IPM program was conducted in several ways. Insecticide use by growers was compared wim IPM program recommendations based on action thresholds to determine the extent to which growers followed the recommendations. In 1984 and 1985, growers who followed the recommendations >60% of me time sprayed less often for CPB and aphid control than did the remaining participating growers, while maintaining acceptable levels of insect control. Based on estimated insecticide costs, growers who followed the recommendations >60% of the time saved from 84 to 143 per ha, compared with participating growers who followed me recommendations less often. Two surveys were completed in 1985. One was developed to determine the opinion of participating growers concerning me IPM scouting program and to discover the areas of program operation that needed improvement. Another survey was conducted to determine the impact of all IPM educational activities on commercial potato growers on Long Island.
ChemInform Abstract: Radical Stability and Its Role in Synthesis and Catalysis (2010)

Abstract Review: ca. 50 refs.
Efficient, Large Area ITO‐and‐PEDOT‐free Organic Solar Cell Sub‐modules (2012)

A transparent top anode consisting of molybdenum oxide (MoOx) and silver (Ag) is employed in an "inverted-illumination" geometry in conjunction with a thick aluminium (100 nm) bottom contact. The optimised MoOx-Ag-MoOx stack (MAMS) has an optical transmission of 80% at the wavelength of 520 nm, sheet resistance of ∼5 ohm sq−1 and yields conversion efficiencies in 5 cm × 5 cm photoactive-area "sub-modules" of 3.17% - outperforming the equivalent conventional ITO/PEDOT:PSS devices.
Data from <i>In vivo</i> Diagnosis of Epidermal Growth Factor Receptor Expression using Molecular Imaging with a Cocktail of Optically Labeled Monoclonal Antibodies (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Epidermal growth factor receptors (EGFR) play an important role in tumorigenesis and, therefore, have become targets for new molecular therapies. Here, we use a “cocktail” of optically labeled monoclonal antibodies directed against EGFR-1 (HER1) and EGFR-2 (HER2) to distinguish tumors by their cell surface expression profiles.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt;&lt;i&gt;In vivo&lt;/i&gt; imaging experiments were done in tumor-bearing mice following s.c. injection of A431 (overexpressing HER1), NIH3T3/HER2+ (overexpressing HER2), and Balb3T3/DsRed (non-expression control) cell lines. After tumor establishment, a cocktail of optically labeled antibodies: Cy5.5-labeled cetuximab (anti-HER1) and Cy7-labeled trastuzumab (anti-HER2) was i.v. injected. &lt;i&gt;In vivo&lt;/i&gt; and &lt;i&gt;ex vivo&lt;/i&gt; fluorescence imaging was done. For comparison with radionuclide imaging, experiments were undertaken using &lt;sup&gt;111&lt;/sup&gt;Indium-labeled antibodies. Additionally, a “blinded” diagnostic study was done for mice bearing one tumor type.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt;&lt;i&gt;In vivo&lt;/i&gt; spectral fluorescent molecular imaging of 14 mice with three tumor types clearly differentiated tumors using the cocktail of optically labeled antibodies both &lt;i&gt;in vivo&lt;/i&gt; and &lt;i&gt;ex vivo&lt;/i&gt;. Twenty-four hours after injection, A431 and NIH3T3/HER2+ tumors were detected distinctly by their peak on Cy5.5 and Cy7 spectral images, respectively; radionuclide imaging was unable to clearly distinguish tumors at this time point. In blinded single tumor experiments, investigators were able to correctly diagnose a total of 40 tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; An &lt;i&gt;in vivo&lt;/i&gt; imaging technique using an antibody cocktail simultaneously differentiated two tumors expressing distinct EGFRs and enabled an accurate characterization of each subtype.&lt;/p&gt;&lt;/div&gt;
High-resolution imaging gamma-ray spectroscopy with externally segmented germanium detectors (1993)

Externally segmented germanium detectors promise a breakthrough in gamma-ray imaging capabilities while retaining the superb energy resolution of germanium spectrometers. An angular resolution of 0.2° becomes practical by combining position-sensitive germanium detectors having a segment thickness of a few millimeters with a one-dimensional coded aperture located about a meter from the detectors. Correspondingly higher angular resolutions are possible with larger separations between the detectors and the coded aperture. Two-dimensional images can be obtained by rotating the instrument. Although the basic concept is similar to optical or x-ray coded-aperture imaging techniques, several complicating effects arise because of the penetrating nature of gamma rays. The complications include partial transmission through the coded aperture elements, Compton scattering in the germanium detectors, and high background count rates. Extensive electron–photon Monte Carlo modeling of a realistic detector/coded–aperture/collimator system has been performed. Results show that these complicating effects can be characterized and accounted for with no significant loss in instrument sensitivity.