gebhart/patrepeval huggingface dataset:
The influence of variations in the measuring procedure on quantitative nuclear image features in histologic sections of lung tissue. (1988)

The qualitative and quantitative features of cell nuclei in tissue sections play an important role in diagnostic histopathology; variations in staining intensity and measuring procedures may interfere with their proper evaluation. To identify nuclear features that are relatively insensitive to these technical variables, the influence of critical steps in a scanning-stage densitometer measuring system was studied on 87 quantitative nuclear image (QNI) features in histologic sections of lung tissue. The influences of the following measuring variations were evaluated: interactive segmentation (with and without median filtering; with and without 5% uniform distributed noise added); scanning (with and without median filtering); calibration of the photomultiplier (different background localizations and different intensity levels); and time. In addition, the influence of artificially changed intensity variations was investigated. The results showed that, while the coefficient of variation (CV) induced by variations in the measuring system was usually low (below 10%), for some QNI features the CV can be high (up to 216%). The influence of artificial variations in intensity was restricted: only a minority of the QNI features showed a significant difference. Of the 87 QNI features, 35 had a CV of less than 10%, and 25 of these were significantly correlated with each other. Thus, only ten uncorrelated, low-CV QNI features remained; these belonged to all of the different QNI feature categories used. These features may be diagnostically important since they may best describe the morphologic properties of the nuclei. The results of this study should help in selecting quantitative nuclear image features that are less sensitive to variations in the measuring procedure and staining intensity.
HyDEn: A Hybrid Steganocryptographic Approach for Data Encryption Using Randomized Error-Correcting DNA Codes (2013)

This paper presents a novel hybrid DNA encryption (HyDEn) approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach.
Balancing risk and reward in a market-based task service (2004)

We investigate the question of scheduling tasks according to a user-centric value metric-called yield or utility. User value is an attractive basis for allocating shared computing resources, and is fundamental to economic approaches to resource management in linked clusters or grids. Even so, commonly used batch schedulers do not yet support value-based scheduling, and there has been little study of its use in a market-based grid setting. In part this is because scheduling to maximize time-varying value is a difficult problem where even simple formulations are intractable. We present improved heuristics for value-based task scheduling using a simple but rich formulation of value, in which a task's yield decays linearly with its waiting time. We also show the role of value-based scheduling heuristics in a framework for market-based bidding and admission control, in which clients negotiate for task services from multiple grid sites. Our approach follows an investment metaphor: the heuristics balance the risk of future costs against the potential for gains in accepting and scheduling tasks. In particular, we show the importance of opportunity cost, and the impact of risk due to uncertainty in the future job mix.
Twelve-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia (2017)

Use of our novel adaptive AP yielded significant reductions in HbA<sub>1c</sub> and hypoglycemia.
“Cold” synthesis of carbon from polyvinyl chloride with the use of an electron beam ejected into the atmosphere (2016)

This work shows the possibility in principle of forming hydrocarbon structures in polyvinyl chloride films free of admixtures and polyvinyl chloride films modified with 5-mass % ferrocene via a radiation chemical transformation in the atmosphere with the use of an electron accelerator with a plasma cathode operating in the pulsed-periodic mode maximal electron energy no higher than 160 keV, pulse length of 40 μs, and current density of 5 mA/cm2. According to the results of semiquantitative X-ray microanalysis, an irradiated polyvinyl chloride film free of admixtures contains 92 of carbon, 6 of oxygen, and 2 mass % of chlorine; the irradiated polyvinyl chloride is an amorphous carbon material. A possible mechanism of the phenomenon is discussed.
The Systemic-Structural Theory of Activity: Applications to the Study of Human Work (2005)

This article offers an introduction to the central concepts and principles of the Systemic-Structural Theory of Activity (SSTA), an activity-theoretical approach specifically tailored to the analysis and design of human work. In activity theory, cognition is understood both as a process and as a structured system of actions. Building on the general theory of activity, SSTA's use of structurally organized analytical units makes it possible to develop taxonomies and theoretical models of human activity which provide a scientific basis for ergonomic design, education, and industrial-organizational psychology. The primary focus of this article is on design problems in ergonomics. Whereas cognitive psychology has shown a tendency to reduce design problem solving to experimental procedures, systemic-structural activity analyses focus on the interrelation between the structure of work activity and the configuration of the material components of work. SSTA presents methods for the classification and description of human work activity, identifying activity during task performance as the primary object of study, using action as one of the major units of analysis. We outline some applications of SSTA to the study of human work processes, and define and discuss some basic concepts and principles of activity theory.
The FBD-method, a generally applicable tool for analyzing power relations (1993)

Starting from the most general case of m-wire unbalanced multiphase power systems with unsymmetrical loads under nonsinusoidal conditions, it is explained how the relations between currents, voltages and power quantities are analyzed in the time domain using the FBD method. Treatment in the frequency domain on the basis of Fourier series expansion of the time functions is also possible. It is shown that components of the total nonactive currents may be compensated without any time delay and without changing the collective instantaneous power. Rules are given for deriving simple equivalent circuits with m-equally structured branches from given voltages and currents.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Peak shaving strategy of power grid with concentrating solar power plant (2017)

This paper analyzed the changes of operation characteristics and peak regulation capability about cogeneration unit before and after heating by concentrating solar power(CSP). Discussed the operation mechanism of wind power accommodation by CSP based on cogeneration operation mode. The optimization model of peak shaving is established, which include CSP, wind power, condensing unit and cogeneration unit. Compared with the traditional model, the new model increased the thermal balance constraints of the system, thermoelectric coupling constraints of cogeneration unit, and the operation constraints of CSP. Case study verifies that the proposed model is valid. The CSP plant based on cogeneration operation mode can effectively improve the wind power accommodation level of power grid and avoid the condensing unit frequently adjust its power, which greatly improved the economy of the system.
Fluorene‐based materials and their supramolecular properties (2009)

Abstract Fluorene‐based π‐conjugated polymers and oligomers combine several advantageous properties that make them well‐suited candidates for applications in organic optoelectronic devices and chemical sensors. This review highlights strategies to synthesize these materials and to tune their absorption and emission colors. Furthermore, methods to control their supramolecular organization will be discussed. In many cases, a delicate interplay between the chemical structure and the processing conditions are found, resulting in a high sensitivity of both structural features and optical properties. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 4215–4233, 2009
NFAT1 in Cord Blood-Derived Human CD4+ T-Cells: Regulatory Implications for Graft vs. Host Disease (102.27) (2007)

Abstract Clinical benefits of umbilical cord blood (UCB) grafts include the lower incidence of acute GVHD following allogeneic transplantation. We have previously demonstrated dramatically lower expression of the NFAT1 transcription factor and its associated transcripts and known binding partners in UCB CD4+ cells following primary stimulation when compared to T-cells obtained from adult blood (AB). We hypothesize that NFAT1 and NFAT1-dependent factors play a critical role in the increased proliferation and decreased cytokine production seen in UCB T-cells. We have now demonstrated in vitro via RNAi-mediated knockdown in AB-derived primary T-cells with RT-PCR and Cytometric Bead Assay that expression of a GVHD-promoting, Th1-type cytokine profile is dependent on expression of NFAT1, and that knockdown of NFAT1 results in a transcriptional and cytokine profile similar to that seen in UCB. However, microarray and RT-PCR time point analyses indicate NFAT1 transcripts are not changed in UCB versus AB CD4+ cells. This may suggest a crucial regulatory role for post-translational events which may preferentially occur in UCB-derived T-cells in vivo. Indeed, we have observed ubiquitination of NFAT1 and rapid rescue of NFAT1 expression following treatment with proteasome inhibitor in UCB-derived T-cells in vitro. NFAT1 in UCB CD4+ cells is shown by co-IP to be significantly more ubiquitinated than in AB-derived cells. Overall, our data indicates that regulation of NFAT1 through ubiquitination and proteasomal degradation, and its subsequent downstream effects may constitute a key difference between T-cells of adult and neonatal origin; specifically that this post-translational modification may serve as a method by which UCB-derived T-cells may prevent NFAT1 activity, impacting their allogeneic response.
Concatenated fiber grating optical monitor (1998)

A new optical wavelength-division-multiplexed (WDM) wavelength monitor comprised of concatenated fiber Bragg gratings and an InGaAsP electroabsorption optical modulator is described. Input WDM signals were modulated at 10 kHz with 15-ns-width pulses and the signals reflected from the gratings were detected with an InGaAs p-i-n photodiode and displayed on an oscilloscope as a series of pulses corresponding to each wavelength component.
Antioxidant Properties of Lignin (1982)

ABSTRACT Since certain dietary antioxidants are generally thought to protect retinol from oxidation during digestion, lignin was tested for its antioxidant properties. Inclusion of 1–10% lignin in the rat diet resulted in an increased (50–100%) deposition of retinol as compared to cellulose‐fed controls. Data indicate that lignin exhibits antioxidant properties in the presence of oil and probably in the presence of other fat‐soluble substances (e.g. vitamins A and E). Animal experiments substantiate this hypothesis. Results suggest both the biochemical and chemical nature as well as the nutritional ramifications of these observations deserve further investigation.
Steroidal analog of a tetrahydrocannabinol (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal analog of a tetrahydrocannabinolRaj K. Razdan, Harry G. Pars, Felix E. Granchelli, and Louis Selig HarrisCite this: J. Med. Chem. 1968, 11, 2, 377–378Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/jm00308a049https://doi.org/10.1021/jm00308a049research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual-band circularly polarised microstrip antennaswith a single feed (1996)

The authors present a novel technique for obtaining circularly polarised (CP) dual frequency operation by using two spur-line band-stop filters within the perimeter of a microstrip patch antenna with optimum feed point location and aspect ratio. This circularly polarised dual frequency operation can be obtained without increasing either the size or the thickness of the patch. Furthermore, through several experiments the authors also demonstrate that the location of the feed point establishes and controls a trade-off between axial ratio and impedance bandwidth.
Fundamental aspects for characterization in continuum damage mechanics (2018)

New issues, derivations, and remarks are presented for the subject of continuum damage mechanics. Emphasis is placed on the fundamental and basic aspects of damage mechanics. This work is a continuation of a previous work of the authors and provides for a complete analysis of the issues discussed previously. The topics discussed include: (1) the true nature of the damage–integrity angle, (2) modeling damaged solids as composite systems, (3) hypothesis of strain equivalence as a special case of the hypothesis of elastic energy equivalence, (4) mechanics of damaged beams, (5) a mean value theorem for damage mechanics, (6) partial damage mechanics characterization, (7) micro-damage or nano-damage, (8) crack and void mechanics, and (9) conceptual modeling of interfacial damage. It is hoped that these new and fundamental concepts will pave the way for new, consistent, and holistic avenues in research in damage mechanics and characterization of materials.
Experimental buckling of cylindrical composite panels with eccentrically located circular delaminations (1987)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Explainable AI for Intelligence Augmentation in Multi-Domain Operations (2019)

Central to the concept of multi-domain operations (MDO) is the utilization of an intelligence, surveillance, and reconnaissance (ISR) network consisting of overlapping systems of remote and autonomous sensors, and human intelligence, distributed among multiple partners. Realising this concept requires advancement in both artificial intelligence (AI) for improved distributed data analytics and intelligence augmentation (IA) for improved human-machine cognition. The contribution of this paper is threefold: (1) we map the coalition situational understanding (CSU) concept to MDO ISR requirements, paying particular attention to the need for assured and explainable AI to allow robust human-machine decision-making where assets are distributed among multiple partners; (2) we present illustrative vignettes for AI and IA in MDO ISR, including human-machine teaming, dense urban terrain analysis, and enhanced asset interoperability; (3) we appraise the state-of-the-art in explainable AI in relation to the vignettes with a focus on human-machine collaboration to achieve more rapid and agile coalition decision-making. The union of these three elements is intended to show the potential value of a CSU approach in the context of MDO ISR, grounded in three distinct use cases, highlighting how the need for explainability in the multi-partner coalition setting is key.
Cover Image, Volume 76, Issue 1 (2019)

ON THE BACK COVER: The back cover image is based on the Research Article Septin‐associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae by Adam M. Perez and Jeremy Thorner, DOI: 10.1002/cm.21524 . image
Plasmid DNA-Based Alphavirus Vaccines (2019)

Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines, primary cell cultures, and in vivo. However, vector engineering has expanded the application range to plasmid DNA-based delivery and expression. Immunization studies with DNA-based alphavirus vectors have demonstrated tumor regression and protection against challenges with infectious agents and tumor cells in animal tumor models. The presence of the RNA replicon genes responsible for extensive RNA replication in the RNA/DNA layered alphavirus vectors provides superior transgene expression in comparison to conventional plasmid DNA-based expression. Immunization with alphavirus DNA vectors revealed that 1000-fold less DNA was required to elicit similar immune responses compared to conventional plasmid DNA. In addition to DNA-based delivery, immunization with recombinant alphavirus particles and RNA replicons has demonstrated efficacy in providing protection against lethal challenges by infectious agents and tumor cells.
Microfiltration of starch suspensions using a tubular stainless steel membrane (2000)

This article reports on the use of a tubular stainless steel-titania composite membrane to filter cornstarch suspensions, with a view to possibly augmenting, or replacing, hydrocyclones or centrifuges which are used for the concentration and purification of starch. This research work focuses on studying the effect of operating parameters such as trans-membrane pressure, cross-flow velocity and feed concentration on the flux and rate of fouling, and on developing cleaning protocols.
Mediating the cultivation of fear through media literacy education (2007)

College students (N = 110) received a media literacy intervention based on critical thinking or they received no intervention. Students were also classified as low or high television viewers based on responses to a Television Use Survey. Fear was measured with a Safety Survey and analyzed with a 2 Intervention x 2 Television Viewing ANOVA. Fear was expected to be lower in the intervention and low television viewing groups than in the no intervention and high television viewing groups. However, no results were significant.
Dual-Loop Frequency Synchronization and Load Regulation using a Discrete Time Model for a 7-Level Switched Capacitor WPT Rectifier (2020)

In wireless power transfer (WPT) applications, the multi-level switched capacitor topology achieves significant advantages in terms of efficiency, system loading, THD, and output regulation. The topology requires dual-loop control in order to harness these benefits. First, a small signal discrete time model for the 7-level rectifier WPT system is developed. Then, a control loop is designed that enables the rectifier to regulate DC load voltage by varying its modulation scheme. Next, the WPT carrier frequency is sensed and a phase-locked loop is used in combination with the small signal power stage model to design a closed-loop controller that synchronizes frequency and regulates control phase through adjustments of the switching period. Finally, cross-coupling interactions between the two control loops are modeled, and stable dual-loop operation is shown.
Unvealing the Principal Modes of Human Upper Limb Movements through Functional Analysis (2017)

The rich variety of human upper limb movements requires an extraordinary coordination of different joints according to specific spatio-temporal patterns. However, unvealing these motor schemes is a challenging task. Principal components have been often used for analogous purposes, but such an approach relies on hypothesis of temporal uncorrelation of upper limb poses in time. To overcome these limitations, in this work we leverage on functional Principal Component Analysis (fPCA). We carried out experiments with 7 s​bjects performing a set of most significant human actions, selected considering state-of-the-art grasp taxonomies and human kinematic workspace. fPCA results show that human upper limb trajectories can be reconstructed by a linear combination of few principal time dependent functions, with a first component alone explaining around 60/70% of the observed behaviours. This allows to infer that in daily living activities humans reduce the complexity of movement by modulating their motions through a reduced set of few principal patterns. Finally, we discuss how this approach could be profitably applied in robotics and bioengineering, opening fascinating perspectives to advance the state of the art of artificial systems, as it was the case of hand synergies.
Estrogen Antagonisms: Effects of a Series of 19-Nortestosterone Derivatives on Vaginal Changes Induced by Estrone (1960)

Summary19-Nortestosterone derivatives are antagonists of estrone in vaginal smear as well as uterine growth tests. Structure-activity relationships among these materials are largely the same in bot...
THE STRUCTURAL DESIGN OF BITUMINOUS ROADS (1984)

Since the 3rd edition of Road Note 29 was published in 1970, further information on road performance has been obtained and there have been important advances in research on materials, methods of construction and mathematical models of pavement behaviour. These advances have been used to develop a new method for the structural design of road pavements. It is based on the performance of experimental roads interpreted in the light of structural theory. The capping layer and sub-base is designed primarily as a construction platform. Design curves are given for the thickness of bituminous, lean concrete or wet-mix roadbase required to carry the traffic expected to use the road during its design life. The design method offers the means of adapting proven designs to take advantage of new materials, new design configurations and construction methods. (Author/TRRL)
The Synergistic Interaction Between Midazolam and Clonidine in Spinally-Mediated Analgesia in Two Different Pain Models of Rats (2001)

Spinally-administered midazolam, a benzodiazepine, and clonidine, an alpha2-adrenergic receptor agonist, have significant synergistic effects on thermally-induced acute and formalin-induced inflammatory pain.