gebhart/patrepeval huggingface dataset:
Pilot error in automated systems shown by altitude deviation reports (1994)

Over 8,000 altitude deviations are reported to NASA's Aviation Safety Reporting System each year. This is almost one an hour. The narratives of pilot incidents relate how errors made in the automation-assisted altitude change task are caused by the difficulty pilots are having interacting with automatic systems. This paper discusses the impact of increased automation in glass-cockpit airliners on the altitude deviations reported by pilots. By observing the way information is processed by the cockpit system, the author suggests that the philosophies of design and training need to change in order to facilitate, not debilitate, the aircrew.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tolypocladium inflatum Is the Anamorph of Cordyceps subsessilis (1996)

A collection of Cordyceps subsessilis is documented. Axenic cultures of single part ascospores produced an anamorph attributable to the common soil hyphomycete Tolypocladium inflatum (= T. niveum). Efrapeptins were identified in culture filtrates of the anamorph. The efrapeptin profile of the C. subsessilis anamorph was found to be similar to that of other isolates of T. inflatum. This is the first report of a teleomorph for this important anamorph genus.
Selectins: An Important Family of Glycan-Binding Cell Adhesion Molecules in Ovarian Cancer (2020)

Ovarian cancer is the most lethal gynecological malignancy worldwide. Unlike most other tumor types that metastasize via the vasculature, ovarian cancer metastasizes predominantly via the transcoelomic route within the peritoneal cavity. As cancer metastasis accounts for the majority of deaths, there is an urge to better understand its determinants. In the peritoneal cavity, tumor-mesothelial adhesion is an important step for cancer dissemination. Selectins are glycan-binding molecules that facilitate early steps of this adhesion cascade by mediating heterotypic cell-cell interaction under hydrodynamic flow. Here, we review the function and regulation of selectins in peritoneal carcinomatosis of ovarian cancer, and highlight how dysregulation of selectin ligand biogenesis affects disease outcome. Further, we will introduce the latest tools in studying selectin-glycan interaction. Finally, an overview of potential therapeutic intervention points that may lead to the development of efficacious therapies for ovarian cancer is provided.
The hydroxypyridones: a class of antimycotics of its own (1997)

The hydroxypyridones chemically form a class of antimycotics not related to others. For a long time ciclopirox olamine has been the only compound to be used clinically. Recently, ciclopirox as a free acid and rilopirox have also been considered. The congeners are active against a broad spectrum of medically relevant fungi including dermatophytes, yeasts and moulds in vitro. According to investigations based on animal and in vivo models for fungal disease, this also applies in vivo. Low toxicity in the experimental animal has made topical applications in man possible. Clinical experience relates, in particular, to dermatophytosis and vaginal candidosis, but rarer conditions have also been investigated. High tolerability corresponds to efficacy in major dermatomycological conditions. Today, interest mainly focuses on ciclopirox lacquer for onychomycosis. Here as in general, the relative role of hydroxypyridones will have to be finally established in comparative trials.
Probabilistic modeling of nodal electric vehicle load due to fast charging stations (2016)

In order to reduce greenhouse gas emission and fossil fuel dependence, Electric Vehicle (EV) has drawn increasing attention due to its zero emission and high efficiency. However, new problems such as range anxiety, long charging duration and high charging power may threaten the safe and efficient operation of both traffic and power systems. This paper proposes a probabilistic approach to model the nodal EV load at fast charging stations in integrated power and transport systems. Following the introduction of the spatial-temporal model of moving EV loads, we extended the model by taking fast charging station into consideration. Fuzzy logic inference system is applied to simulate the charging decision of EV drivers at fast charging station. Due to increasing EV loads in power system, the potential traffic congestion in fast charging stations is modeled and evaluated by queuing theory with spatial-temporal varying arrival and service rates. The time-varying nodal EV loads are obtained by the number of operating fast chargers at each node of the power system. System studies demonstrate that the combination of AC normal and DC charging may share the EV charging demand and alleviate the impact to power system due to fast charging with high power.
Supplementary Table S5 from The Pharmacokinetic–Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST (2023)

&lt;p&gt;Tested dose and efficacy data for across tumor models investigated for AZD3229 and standard of care compounds&lt;/p&gt;
Electricity Generation with Camphor as Fuel (2014)

This paper deals with the economic and efficient way to generate electicity. Many may think this method will not be feasible. But once this is executed electricity will be generated very easily. When comparing with other fuels the quantity required may be high but it is ecofriendly and economic. Moreover camphor is bio degradable and can be prepared artificially in lab also.
Adaptive frequency regulation strategy based integral sliding mode control for smart grid with renewable energy sources (2015)

With the blooming deployment of renewable resources, more and more renewable energy are used in the power system, especially in the island smart grid. As the power generation is variable, the smart grid integrated renewable energy, such as photovoltaic (PV) or wind enσergy, may cause large system frequency fluctuations. In this paper, it studies the adaptive on-line frequency control in the island smart grid for multiple renewable energy, mainly concerning PV array and wind energy. The integral sliding mode controller is involved to be as a primary frequency regulator to suppress the frequency fluctuations and maintain the stability of the island smart grid, and the adaptive dynamic programming method is used as an on-line regulator to improve the adaptive capacity of the sliding mode regulator, which would provide an supplementary control added to the primary sliding mode control. Comparative simulation studies on a benchmark smart grid with a turbine, PV array and wind power are carried out among the proposed adaptive regulation scheme, the SM regulator and the PI regulator. The simulation results have fully demonstrated the competitive performance and the adaptive ability of the intelligent frequency regulation.
Supplementary Figure 3 from Glucocorticoids Antagonize Estrogens by Glucocorticoid Receptor–Mediated Activation of Estrogen Sulfotransferase (2023)

Supplementary Figure 3 from Glucocorticoids Antagonize Estrogens by Glucocorticoid Receptor–Mediated Activation of Estrogen Sulfotransferase
Spatial and Temporal Influences on Discrimination of Vibrotactile Stimuli on The Arm (2018)

Body-machine interfaces (BMIs) provide a non-invasive way to use and control external devices such as powered wheelchairs. Vibrotactile stimulation has been proposed as a way for BMIs to provide device performance feedback to the user, thereby reducing visual demands of closed-loop control. To advance the goal of developing a compact, multivariate vibrotactile display for BMIs, we performed two 2-alternative, forced choice experiments to determine the extent to which vibrotactile perception might vary across multiple stimulation sites. The first experiment assessed vibrotactile discrimination of sequentially presented stimuli within each of four dermatomes of the arm (C5, C7, C8, T1) and on the ulnar head. The second compared discrimination when pairs of vibrotactile stimuli were presented simultaneously vs. sequentially both within and across dermatomes. Although the first experiment found small but statistically significant differences across dermatomes C7 and T1, discrimination thresholds at the other three locations did not differ one from another or from those at either C7 or T1. These results suggest that stimuli applied to each of the sites may be able to convey approximately the same amount of information. The second experiment found that sequential delivery of vibrotactile stimuli resulted in better discrimination than simultaneous delivery, independent of whether the pairs were located within the same dermatome or across dermatomes. Taken together, our results suggest that the arm may be a viable site to transfer multivariate information via vibrotactile feedback for body-machine interfaces. However, user training may be needed to overcome the perceptual disadvantage of simultaneous vs. sequentially-presented stimuli.
Herpesvirüs Saimiri’nin Alternatif Gen Terapi Vektörü Olarak Kullanımı (2016)

Herpesvirus saimiri is the prototype rhadinovirus and is closely related to human Kaposi’s sarcoma-associated herpesvirus. Herpesvirus saimiri strains of subgroup C transduce a broad spectrum of cancer cells and primary cells including human T lymphocytes very efficiently and enable stable transgene expression. Herpesvirus saimiri as a gene therapy vector is favorable because of its large packaging capacity, extensive cell tropism, and long-termed persistence as non-integrating episomes and thus exhibits numerous advantages over commonly used viral vectors. In order to use Herpesvirus saimiri as a secure and versatile gene therapy vehicle, it should be easily manipulated and modified. The recent advances in molecular cloning of large genomic fragments such as virus genomes as bacterial artificial chromosomes facilitated the functional studies and manipulation of herpesviruses using the recombination system of bacteria. Among these, red-recombination based “en passant” mutagenesis method enables seamless genome modification such as deletion, insertion and point mutation very easily and efficiently.
Electron paramagnetic resonance ofGd3+ions in the superconductorGdBa2Cu3Ox (1987)

EPR from ${\mathrm{Gd}}^{3+}$ ions in the high-${T}_{c}\ensuremath{\simeq}90$ K superconductor $\mathrm{Gd}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{x}$ is reported. The temperature dependence of the linewidth and intensity of the ${\mathrm{Gd}}^{3+}$ ions in the vicinity of ${T}_{c}$ are related to the corresponding characteristics of the ${\mathrm{Cu}}^{2+}$ ions.
Nonnutritive Sweeteners: Taste-Structure Relationships for Some New Simple Dihydrochalcones (1977)

Six sweet and five nonsweet simple nonglycosidic dihydrochalcones were prepared, two of which have properties comparable to those of the intensely sweet neohesperidin dihydrochalcone.
Visão de educadoras sociais junto ao trabalho educativo realizado na prevenção das DST/aids (2009)

Este estudo objetiva traçar um perfil sociodemográfico das educadoras sociais (ES) da Associação das Prostitutas do Ceará (APROCE) e investigar a visão dessas mulheres junto ao trabalho educativo realizado na prevenção das DST e Aids. Pesquisa do tipo descritiva, com abordagem qualitativa. A coleta de dados realizou-se de novembro/2006 a janeiro/2007, acompanhando as ES a algumas zonas de prostituição de Fortaleza. Os dados foram agrupados em duas categorias: caracterização das educadoras sociais e diálogo com as educadoras sociais; e examinados segundo a análise crítica. Observou-se que as estratégias de educação em saúde utilizadas pela APROCE não estão estimulando mudança de comportamento, pois muitas prostitutas ainda mantêm relações sexuais com seus parceiros sem preservativo. Embora a APROCE transmita informações sobre a prevenção de DST/Aids e distribua preservativo, as estratégias utilizadas pela associação devem ser aprimoradas de modo a promover a autocrítica sobre o comportamento adotado. DOI:https://doi.org/10.15253/2175-6783.20090004000010
Supplementary Figure Legend 1, Table Legends 1-5 from PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors (2023)

&lt;p&gt;PDF file - 49K&lt;/p&gt;
Detection of geological structure using gamma logs for autonomous mining (2011)

This work is motivated by the need to develop new perception and modeling capabilities to support a fully autonomous, remotely operated mine. The application differs from most existing robotics research in that it requires a detailed world model of the sub-surface geological structure. This in-ground geological information is then used to drive many of the planning and control decisions made on a mine site. This paper formulates a method for automatically detecting in-ground geological boundaries using geophysical logging sensors and a supervised learning algorithm. The algorithm uses Gaussian Processes (GPs) and a single length scale squared exponential covariance function. The approach is demonstrated on data from a producing iron-ore mine in Australia. Our results show that two separate distinctive geological boundaries can be automatically identified with an accuracy of over 99 percent. The alternative approach to automatic detection involves manual examination of these data.
Characterization and regulation of rat microglial Ca2+ release-activated Ca2+ (CRAC) channel by protein kinases (2000)

We measured the activity of the Ca(2+) release-activated Ca(2+) (CRAC) channel present in cultured rat microglia, using the whole-cell mode of patch clamp technique. When the concentration of divalent cations in external solution was reduced to the micromolar range, and Ca(2+) chelating agent BAPTA was included in the pipette solution, we were able to record Na(+) current through CRAC channels in single-channel levels. The unitary Na(+) conductance through CRAC channel was 42.5 pS, which was similar to that of Jurkat cell. The Na(+) current activated slowly, reaching the maximal current level in about 10 min after whole-cell patches were made. The time required for the half-maximal activation of the current was 205 s (+/-31), while it was reduced to 84.3 s (+/-17.7) by including IP(3) in the pipette solution as well. The peak currents ranged from 320 to 985 pA, which corresponded to 64-197 channels per cell. We studied the regulation of the current by protein kinase A (PKA) and protein kinase C (PKC). The current was enhanced by the addition of membrane-permeant analogue of cAMP, dibutyryl cAMP. Pretreating cells with PKA inhibitor, H-89, prevented the effect of dibutyryl cAMP. By contrast, the addition of PKC activator, PDBu, reduced the current. Staurosporine, a PKC inhibitor, prevented the effect of PDBu. These results suggest that CRAC channel in rat microglia is under the regulation of PKA and PKC in opposite directions.
Evaluation of bioethanol production from juice and bagasse of some sweet sorghum varieties (2015)

Sweet sorghum, with sugar-rich stalks and water-use efficiency, has a very good potential as an alternative feedstock for ethanol and also non-competing with human feed on land. The present study evaluates the exploitation of juice and bagasse of five varieties of sweet sorghum for bioethanol production which can further improve the energy yield of the crop. The sweet sorghum varieties, GK-coba, Mn-1054, Ramada, Mn-4508 and SS-301, were analyzed for their productivity, and sugar and fiber contents. All varieties significantly differed in yield of stripped stalk, juice and bagasse. The sugar-rich juice and the fiber-rich bagasse, resulting from squeezing the striped stalks, were used for bioethanol production by two microorganisms; Saccharomyces cerevisiae ATCC 7754 and Zymomonas mobilis ATCC 29191. Stalks of varieties GK-coba, Mn-4508 and SS-301 contained high sugar contents and thus were utilized for bioethanol production directly from juice. Stalks of varieties Mn-1054, Ramada and SS-301 had higher content of fibers, so their bagasses were used for bioethanol production. Bagasse was pretreated and hydrolyzed thermo-chemically with 2% (v/v) sulfuric acid (98%) at 120 °C for 60 min and filtered and the sugar-rich filtrate was neutralized and supplemented with nutrients for bioethanol production. Fermentation of sweet sorghum sugars or acid-hydrolyzed neutralized bagasse into bioethanol was conducted by Sacch. cerevisiae, Z. mobilis or mixed-culture of both organisms at 1:1 ratio. The highest bioethanol production was obtained from juice and bagasse of variety SS-301, by the mixed-culture treatment. From the juice, bioethanol concentration was 50.26 mL L−1, whereas from bagasse, bioethanol concentration was 10.5 mL L−1. Finally, it could be estimated that 160 mL of bioethanol can be produced out of each 1 kg of variety SS-301, when using both juice and bagasse.
Discriminating semi-continuous HMM for speaker verification (2002)

This paper describes the use of a multiple codebook SCHMM speaker verification system, which uses a novel technique for discriminative hidden Markov modelling known as discriminative observation probabilities (DOP). DOP can easily be added to a multiple codebook HMM system and require minimal additional computation and no additional training. The DOP technique can be applied to both speech and speaker recognition. Results are presented for text-dependent experiments on isolated digits from 27 true speakers and 84 casual imposters, recorded over the public telephone network in the United Kingdom. DOP are shown to significantly improve speaker verification performance for several commonly used parameter sets.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 2000: Cancer metastasis driven by the novel MEK1 substrate MACC1 is restricted by clinically applicable MEK1 inhibitors (2019)

Abstract Cancer metastasis is responsible for &amp;gt;90% of cancer deaths and remains a major treatment challenge. In search of new drivers of metastasis we identified the novel, previously undescribed gene Metastasis-Associated in Colon Cancer 1 (MACC1) in human colorectal cancer (CRC). MACC1 induces fundamental processes like proliferation, migration, invasiveness and metastasis in xenografted and transgenic mice. MACC1 has been established by us and many other groups as key player, prognostic and predictive biomarker for tumor progression and metastasis in &amp;gt;20 solid cancer types. Proof-of-concept for MACC1 as a therapeutic target to restrict cancer progression and metastasis was provided by transcriptional and post-transcriptional downregulation of MACC1 for several solid cancers, including CRC. Specific inhibitors targeting MACC1 post-translational protein modifications to restrict tumor growth and metastasis are not identified so far. Here we report the identification of MACC1 as a newly identified substrate of the kinase MEK1 (MAP2K1). MEK1 directly phosphorylates MACC1 leading to accelerated and increased ERK1 activation. Mutating three potential hierarchical MACC1 tyrosine phosphorylation sites abrogates MACC1 dependent target gene expression like MET, cell proliferation and motility in cell culture and importantly, metastasis in mouse xenograft models. Targeting MEK1 by RNAi or by clinically applicable MEK1 inhibitors like AZD6244 and GSK1120212 reduces MACC1 tyrosine phosphorylation and restricts MACC1-induced metastasis formation. Our findings demonstrate that MAP kinase signaling is not linearly leading only to ERK activation, but branches at the level of MEK1. In summary, MACC1 tyrosine phosphorylation is decisive for tumor growth and metastasis. The fundamental finding of MACC1 being a newly identified MEK1 substrate opens new therapeutic options with potential for clinical translation. Targeting MACC1 tyrosine phosphorylation using MEK1 inhibitors thereby intervening in MACC1-induced metastasis aims at the ultimate goal of personalized therapies for inhibition of cancer progression and metastasis, resulting in improved patient survival. Since MACC1 is confirmed as decisive driver for tumor growth and metastasis in a variety of solid cancers, the findings made here for CRC might be translated to further solid tumor types. The usefulness of MACC1 as therapeutic target towards MEK1 inhibitor treatment requires confirmation in clinical trials. Citation Format: Dennis Kobelt, Daniel Perez-Hernandez, Claudia Fleuter, Mathias Dahlmann, Fabian Zincke, Janice Smith, Rebekka Migotti, Susen Burock, Wolfgang Walther, Gunnar Dittmar, Ulrike S. Stein. Cancer metastasis driven by the novel MEK1 substrate MACC1 is restricted by clinically applicable MEK1 inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2000.
Is age a determinant factor in EVAR as a predictor of outcomes or at procedure selection? Our experience (2016)

The absence of statistically differences in mortality and reinterventions among age groups suggests that age by itself is not a relevant factor in endovascular aneurysm repair. Indeed, the three characteristics different in younger (obesity, sexual function and patient's choice) favor endovascular aneurysm repair.
Expression and significance of related resistance genes in hepatocellular carcinoma (2013)

Objective To investigate the expressions of P-glycoprotein(P-gp),excision repair cross complementing 1(ERCC1) and thymidylate synthetase(TS) in hepatocellular carcinoma and explore the correlation with the multidrug resistance in hepatocellular carcinoma(HCC).Methods The expressions of P-gp,ERCC1 and TS were detected in 48 cases of HCC tissue(HCC group) and 43 cases of tumor-adjacent tissue(control group) by using S-P immunohistochemical staining(SP) and the results were compared.Results The positive rates of P-gp,ERCC1 and TS were 85.4%,56.3%,50.0% in HCC group,obviously higher than those in control group(51.2%,9.3%,20.9%)(P0.05).The positive rate of P-gp was significantly higher than that of ERCC1 or TS(P0.05),and the coexpression rate of two or three multidrug resistance genes was higher than individual expression rate in HCC group(P0.05).The positive expression of ERCC1 was higher in increased alpha-fetoprotein level group than that in normal alpha-fetoprotein level group(P0.05).Conclusion The multidrug resistance of HCC is correlated with the expressions of P-gp,ERCC1 and TS.The combined detection of P-gp,ERCC1 and TS may guide the clinical use of drugs and predicate chemotherapy effects.
<title>In-vivo assessment of acetic acid-cervical tissue interaction using quantitative imaging of backscattered light: its potential use for in-vivo cervical cancer detection grading and mapping</title> (1999)

Topical application of acetic acid solution is routinely used as a marker for the clinical diagnosis of cervical cancer and more specifically to direct biopsy sampling. Abnormal areas are visualized as transient white patches and there are several evidences that acetic acid-tissue interaction kinetics is correlated with the malignancy grade. The visual assessment of this interaction can not be effective and therefore the obtained diagnostic information is limited. In this paper a new method and a multi-spectral imaging system are presented, capable to enhance the contrast between normal and acetic acid responsive tissue areas and to assess quantitatively the kinetics of acetic acid-tissue interaction. The former is achieved by cutting-off the regular reflection, in combination with the selection of the appropriate imaging spectral band. The second is achieved with the dynamic measurement of the intensity of the back-scattered light in any spatial point of the image, after acetic acid application. The obtained quantitative data provide a means for the early detection, and more accurate grading and mapping of the lesion. This method was experimentally implemented to colposcopy and a remarkable improvement of the sensitivity specificity and reproducibility was demonstrated during in initial clinical trials.