gebhart/patrepeval huggingface dataset:
Double‐blind, placebo‐controlled comparison of rabeprazole 20 mg vs. omeprazole 20 mg in the treatment of erosive or ulcerative gastro‐oesophageal reflux disease (1999)

In this study, GERD healing rates following rabeprazole 20 mg once daily were equivalent to those obtained with omeprazole 20 mg once daily. Both treatments resulted in a comparable relief of the frequency and intensity of heartburn associated with this disease, and both were well tolerated.
Quantum Impurities and the Neutron Resonance Peak inYBa2Cu3O7: Ni versus Zn (2000)

The influence of magnetic (S=1) and nonmagnetic (S=0) impurities on the spin dynamics of an optimally doped high temperature superconductor is compared in YBa2(Cu0.97Ni0.03)3O7 (Tc=80 K) and YBa2(Cu0.99Zn0.01)3O7 (Tc=78 K). In the Ni-substituted system, the magnetic resonance peak (which is observed at Er approximately 40 meV in the pure system) shifts to lower energy with a preserved Er/Tc ratio while the shift is much smaller upon Zn substitution. By contrast Zn, but not Ni, restores significant spin fluctuations around 40 meV in the normal state. These observations are discussed in the light of models proposed for the magnetic resonance peak.
Synergistic effect of interleukin 1 and soluble CD23 on the growth of human CD4+ bone marrow‐derived T cells (1991)

Low-affinity Fc epsilon receptor (Fc epsilon RII/CD23) is expressed by various human cells and known to be cleaved into soluble fragments (sCD23). Several biological activities were ascribed to these molecules. In this study, we have assessed the effect of recombinant 25-kDa sCD23 (rsCD23) on human bone marrow-derived T cells. Our results show that rsCD23 in synergy with recombinant interleukin 1 enhances mitogenic responsiveness of CD4+ T cells but does not affect CD8+ cell growth. Furthermore, rsCD23 synergizes autologous marrow cells in enhancement of CD4+ cell growth while CD23 monoclonal antibodies decrease accessory cell effect. Together, these data confirm cytokine-like activity of sCD23 on human T cell lineage.
Coronary artery calcification in COPD is associated with adverse functional assessments and mortality (2012)

COPD is associated with coronary artery disease (CAD). Coronary artery calcium score (CACS) can identify and stratify risk in CAD. We evaluated CACS and its relationship with clinical outcomes using non-gated chest CT in a well-characterised cohort of COPD patients (ECLIPSE study). CACS (Agatston score) was assessed in 946 patients (COPD n=676, FEV1% predicted 48.7±16.1, age 63.2±7.0yrs; Smoker controls: n=199, FEV1% predicted 110.0±11.5, age 54.1± 8.5yrs; Non-smoker controls: n=71, FEV1% predicted 114.4±13.8, age 54.7±9.2yrs). CACS was higher in COPD patients than smoker or non-smoker controls (415±689 vs 141.7±396.4 vs 66.6±228.5, p Thus in a cohort of COPD patients higher CACS was associated with poor function and increased mortality. Supported by GlaxoSmithKline (SCO104960, NCT00292552).
Graphene Oxide and Thermally Exfoliated Graphene Cyanate Ester Resin Composites (2013)

Abstract : Recent investigations of cyanate ester resins as high temperature resin materials for space and propulsion applications have brought attention to the need for high temperature composite materials with improved stiffness, strength, hot/wet performance and high maximum use temperatures. The addition of nanocomposite filler materials has been shown to provide property improvement to cyanate ester resins, but often only at high loading levels and with improvement in only one property. Graphene, an allotrope of carbon, is the strongest material yet measured and displays exceptionally high thermal conductivity, electrical conductivity and gas impermeability. Since graphene is an atomically thick monolayer of carbon atoms arranged in a honey-comb lattice, its high surface to volume ratio allows property improvements at lower weight fractions than other composite fillers. The morphology, surface chemical functionality and thermal properties of graphene vary depending on the method of isolation from graphite and subsequent chemical and thermal treatments. Two forms of graphene, graphene oxide and thermally reduced graphene oxide, were dispersed in a commercial cyanate ester resin. The methods of graphene synthesis, isolation and incorporation of graphene into cyanate resin networks will be presented, as will preliminary property investigations of graphene-polycyanurate composites.
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones (2006)

Growth cones at the tips of nascent and regenerating axons direct axon elongation. Netrin-1, a secreted molecule that promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMP (cAMP) levels in growth cones and regulates growth cone morphology and axonal outgrowth. These morphological effects depend on the intracellular levels of cAMP. However, the specific pathways that regulate cAMP levels in response to netrin-1 signaling are unclear. Here we show that 'soluble' adenylyl cyclase (sAC), an atypical calcium-regulated cAMP-generating enzyme previously implicated in sperm maturation, is expressed in developing rat axons and generates cAMP in response to netrin-1. Overexpression of sAC results in axonal outgrowth and growth cone elaboration, whereas inhibition of sAC blocks netrin-1-induced axon outgrowth and growth cone elaboration. Taken together, these results indicate that netrin-1 signals through sAC-generated cAMP, and identify a fundamental role for sAC in axonal development.
Multivariate analyzer based on SM-3 computer and camac hardware (1986)

This paper presents an automatic data-acquisition system based on CAMAC hardware and an SM-3 computer. The hardware and software allow full automation of experiments. The system sets specified hardware parameters and stores data. The maximum write speed is about 10/sup 4/ sec/sup -1/. Real-time observation of incoming data is possible.
Coded wireless temperature sensors with design specified sensitivity (2010)

ASR&D has developed a patented surface acoustic wave (SAW) temperature sensor with individual sensor identification codes and design-controlled temperature sensitivity. Temperature sensitivities demonstrated during this work range from -165ppm/°C to +680 ppm/°C, all on YZ lithium niobate, a piezoelectric substrate with an inherent temperature sensitivity of magnitude 94ppm/°C. A set of 32 individually identifiable coded SAW temperature sensor devices were developed. Wireless measurements confirmed the ability to selectively detect any single sensor out of the combined response of multiple sensors. The wireless electronic reader system currently being developed at ASR&D is a single-channel reader that can be manually adjusted to select any one sensor out of a group of up to 32 sensors simultaneously operating in the field of view (FOV) of the reader. This system avoids code collision problems typical of prior coded SAW wireless sensor systems, and can be extended to read 32 or more sensors operating in the FOV of one reader, at ranges of up to 100 feet, with sampling times of 1-10 msec.
Role of Novel C-Type Lectin Receptor DCL-1 in Phagocytes and Dendritic Cells. (2007)

Abstract Cell surface C-type lectins are implicated in many aspects of immunity. For example, professional phagocytes utilise cell surface C-type lectins in pathogen recognition/binding and phagocytosing the pathogens for destruction and/or antigen processing (e.g. mannose receptor, DC-SIGN, dectin-1). Some C-type lectins are involved in cell-cell adhesion and trafficking of leukocytes (e.g. selectins). DCL-1 is a small type I transmembrane C-type lectin receptor, discovered as a genetic fusion partner of DEC-205. DCL-1 protein was highly conserved amongst the human, mouse and rat orthologs. The human DCL-1 gene, composed of 6 exons, was located to a cluster of type I transmembrane C-type lectin genes on chromosomal band 2q24. Multiple expression array, RT-PCR and FACS analysis using new anti-hDCL-1 mAbs established that DCL-1 expression in leukocytes was restricted to monocytes, macrophages, granulocytes and DC, although DCL-1 mRNA was present in many tissues. Stable hDCL-1 CHO cell transfectants endocytosed FITC-conjugated anti-hDCL-1 mAb rapidly (t1/2 = 20 min) and phagocytosed anti-hDCL-1 mAb-coated microbeads, indicating that DCL-1 may act as an antigen uptake receptor. However, anti-DCL-1 mAb-coated microbead binding and subsequent phagocytic uptake by macrophages was ∼8-fold less efficient than that of anti-macrophage mannose receptor (MMR/CD206) or anti-DEC-205/CD205 mAb-coated microbeads. Confocal studies showed that DCL-1 colocalized with F-actin in filopodia, lamellipodia and podosomes in macrophages and the colocalization was not affected with cytochalasin D, whereas the MMR/CD206 and DEC-205/CD205 did not colocalize with F-actin. Furthermore, DCL-1-EGFP transiently expressed in COS-1 cells colocalized with F-actin at cellular cortex and microvilli. These data suggest that hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis, but also in myeloid cell adhesion and migration.
Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study (2018)

Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.
Experimental Assessment of Leptomeningeal Metastasis Diagnosis in Medulloblastoma Using Cerebrospinal Fluid Metabolomic Profiles (2021)

Diagnosing leptomeningeal metastasis (LM) in medulloblastoma is currently based on positive cerebrospinal fluid (CSF) cytology or magnetic resonance imaging (MRI) finding. However, the relevance of discordant results has not been established. We evaluated the diagnostic potential of CSF metabolomic profiles in the medulloblastoma LM assessment. A total of 83 CSF samples from medulloblastoma patients with documented MRI and CSF cytology results at the time of sampling for LM underwent low-mass ions (LMIs) analysis using liquid chromatography-mass spectrometry. Discriminating LMIs were selected by a summed sensitivity and specificity (>160%) and LMI discriminant equation (LOME) algorithms, evaluated by measuring diagnostic accuracy for verifying LM groups of different MRI/cytology results. Diagnostic accuracy of LM in medulloblastoma was 0.722 for cytology and 0.889 for MRI. Among 6572 LMIs identified in all sample, we identified 27 discriminative LMIs differentiating MRI (+)/cytology (+) from MRI (-)/cytology (-). Using LMI discriminant equation (LOME) analysis, we selected 9 LMIs with a sensitivity of 100% and a specificity of 93.6% for differentiating MRI (+)/cytology (+) from MRI (-)/cytology (-). Another LOME of 20 LMIs significantly differentiated sampling time relative to treatment (<i>p</i> = 0.007) and the presence or absence of LM-related symptoms (<i>p</i> = 0.03) in the MRI (+)/cytology (-) group. CSF metabolomics of medulloblastoma patients revealed significantly different profiles among LM diagnosed with different test results. We suggest that LM patients could be screened by appropriately selected LOME-generated LMIs to support LM diagnosis by either MRI or cytology alone.
Comparison of Minimally Invasive Inductively Coupled Plasma–Mass Spectrometry Approaches for Strontium Isotopic Analysis of Medieval Stained Glass with Elevated Rubidium and Rare-Earth Element Concentrations (2021)

Different approaches for the determination of the <sup>87</sup>Sr/<sup>86</sup>Sr isotope ratio of high-Rb glass are compared in this work to assess the suitability of minimally invasive approaches for applications on medieval stained glass (from the ancient Abbey of Stavelot in Belgium). It was found that pneumatic nebulization multicollector inductively coupled plasma-mass spectrometry (PN-MC-ICP-MS) after acid digestion and chromatographic isolation of the target analyte out of the sample matrix can still be seen as the preferred method for the high-precision isotopic analysis of Sr in glass with high Rb and rare-earth element (REE) concentrations. Alternatively, the use of laser ablation (LA) for sample introduction is a powerful technique for the direct analysis of solid samples. However, both the high Rb/Sr ratios in the samples of interest and the presence of REEs at sufficiently high concentrations lead to a large bias in LA-MC-ICP-MS, which cannot be corrected for, even by operating the MC-ICP-MS instrument at higher mass resolution and/or using mathematical corrections. It was demonstrated that LA tandem-ICP-MS (LA-ICP-MS/MS) using CH<sub>3</sub>F/He as the reaction gas to overcome spectral overlap in a mass-shift approach (chemical resolution) provides a viable alternative when (quasi) nondestructive analysis is required. This approach relies on the monitoring of Sr<sup>+</sup> (<i>m/z</i> = 86, 87, and 88) ions as the corresponding SrF<sup>+</sup> reaction product ions (<i>m/z</i> = 105, 106, and 107), thus avoiding the occurrence of spectral interference. Self-evidently, the isotope ratio precision attainable using sequential quadrupole-based ICP-MS instrumentation (0.3% RSD) was found to be significantly worse than that of high-precision MC-ICP-MS (0.03% RSD) with simultaneous detection, although it was still fit for the purpose of current applications. In addition to Sr isotopic analysis, the REE patterns and their potential influence on the Sr isotopic composition were evaluated by LA-ICP-MS.
Novel Channel-First Fishbone FETs With Symmetrical Threshold Voltages and Balanced Driving Currents Using Single Work Function Metal Process (2022)

In this article, one feasible fabrication approach for novel fishbone FETs using the channel-first and single work function metal (sWFM) processes is proposed and investigated by 3-D technical computer-aided design (TCAD) simulations. Through a small modification on the fabrication process of general gate-all-around (GAA) nanosheet FETs (NSFETs), the special fishbone-like channel composed of vertically stacked Si NSs and sandwiched SiGe nano-fins is experimentally demonstrated by the channel-first process. The simulated electrical characteristics show that the width of the nano-fins should be within 5 nm for a better gate control. Unlike traditional NSFETs, symmetrical threshold voltages ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V}_{\text {th}}\text{s}$ </tex-math></inline-formula> ) for n-type and p-type fishbone FETs can be achieved by using a sWFM, and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\Delta {V}_{\text {th}}$ </tex-math></inline-formula> is optimized by 99.26% compared with that of NSFETs. Meanwhile, it is also found that the SiGe nano-fins contribute more driving current for p-type devices. Therefore, the proposed fishbone FETs with sWFM not only exhibit significantly enhanced driving current but also provide good balance between the performances of n-type and p-type fishbone FETs with a little extra process cost.
Dynamics modeling of human–machine control interface for underwater teleoperation – ERRATUM (2021)

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Economic scheduling in smart grid with nondispatchable and dispatchable loads (2013)

A smart grid is expected to be more flexible and more reliable than traditional electric power grids. Smart grid technology combines, photovoltaic systems, wind turbines, fuel cells, energy storages and electric vehicles charging from the grid and discharging back to the grid. Electric vehicles are one of the key pieces of the renewable energy economy of the future, but they do come with a few challenges- charging electric vehicles can add considerably to a home's overall electricity use, and - when scaled up to thousands or millions of homes - that charging places a lot of extra demand on an electrical grid. This paper presents an economical insight into the management of renewable energy generation and charging/discharging of electric vehicles. This analysis will make use of an approach that will not only reduce the operational cost of renewables and capital cost of energy storages, it will also save cost for electric vehicle owners.
A low cost, reliable, hermetically sealed, chip slapper detonator suitable for various aerospace applications (1999)

EG&G Optoelectronics has developed a low cost, reliable, hermetically sealed, chip slapper detonator for the US Army’s anti-tank weapons platforms. This detonator is also qualified and under consideration for several US Navy and Air Force programs. This detonator would also be suitable for various aerospace applications. The design goal for this detonator was to develop a detonator that was as cost efficient as possible and yet was extremely reliable. The detonator was also designed to survive the most severe environments. The detonator has been subjected to a wide variety of electrical, mechanical, and thermal conditioning and has performed successfully afterwards. The detonator was designed to be a commercial off-the-shelf detonator that would be suitable for almost any application. It uses an insensitive explosive compound, HNS-IV, which eliminates the hazards inherent in the more common hot-wire detonators. All of the detonator components, including the explosive, were manufactured from readily available starting materials. The HNS IV explosive meets EG&G specifications based on the military specifications, The detonator, packaged in a TO-5 can, comes in three configurations: a “plug in” detonator, a surface mount design, and a detonator that can be attached to a flexible cable. This paper will present the detonator design and test results. The full test report is contained in an EG&G Technical Report.’
Effects of Endotoxin on Macrophages and Other Lymphoreticular Cells (1973)

Journal Article Effects of Endotoxin on Macrophages and Other Lymphoreticular Cells Get access A. C. Allison, A. C. Allison From the Clinical Research Centre, Harrow, Middlesex, England Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Davies, P. Davies From the Clinical Research Centre, Harrow, Middlesex, England Search for other works by this author on: Oxford Academic PubMed Google Scholar R. C. Page R. C. Page From the Clinical Research Centre, Harrow, Middlesex, England Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 128, Issue Supplement_1, July 1973, Pages S212–S219, https://doi.org/10.1093/infdis/128.Supplement_1.S212 Published: 01 July 1973
Ring-Pattern Dynamics in Smectic-C*and Smectic-CA*Freely Suspended Liquid Crystal Films (2000)

Ring patterns of concentric 2pi solitons in molecular orientation form in freely suspended chiral smectic-C films in response to an in-plane rotating electric field. We present measurements of the driven dynamics of ring formation under conditions of synchronous winding and of the zero-field relaxation of ring patterns, and propose a simple model which enables their quantitative description in low polarization DOBAMBC. In smectic-C*A TFMHPOBC we observe an odd-even layer number effect, with odd layer number films exhibiting order of magnitude slower relaxation rates than even layer films. We show that this rate difference is due to a much larger spontaneous polarization in odd layer number films.
Pathological complete response after preoperative chemotherapy including FOLFOX plus bevacizumab for locally advanced rectal cancer (2019)

We present the rare case of a patient with surgically resected locally advanced rectal cancer who demonstrated an impressive pCR with preoperative chemotherapy, which included FOLFOX plus bevacizumab.
An extended bandwidth Doherty power amplifier using a novel output combiner (2014)

This paper proposes a novel output combiner for Doherty power amplifiers with extended bandwidth. The proposed output combiner employs a resonance LC tank at the output of the peaking transistor to maintain the back-off impedance seen by the main transistor over a wide frequency band. In addition, the output combiner provides low low-frequency impedance for both the main and peaking transistors which results in improved linearizability when the amplifier is concurrently driven with dual-band modulated signals. A 20W, 30% bandwidth gallium nitride Doherty power amplifier based on the proposed topology was implemented to demonstrate the effectiveness of the output combiner. The Doherty amplifier was successfully linearized under single- and dual-band modulated excitations and achieved 42% power added efficiency when amplifying a concurrent dual-band 15 MHz WCDMA and 15MHz LTE signals with 9:4dB peak-to-average power ratio.
Transgenic Plants Expressing Antimicrobial Lactoferrin Protein are Resistant to a Fungal Pathogen (2010)

Transgenic tobacco (Nicotiana tabacum var Xanthi) and Arabidopsis (A. thaliana) plants expressing an antimicrobial bovine lactoferrin (BLF) gene were developed and evaluated for resistance against an economically important fungal pathogen Rhizoctonia solani, the causal agent of damping off diseases. The plants were transformed with the Agrobacterium strain C58C1 containing a plasmid construction carrying a modified BLF cDNA. The introgression of BLF cDNA into susceptible tobacco and Arabidopsis lines was confirmed by Southern blot and the expression of full-length lactoferrin transcript and protein was also detected by Northern and Western blots, respectively. Transgenic lines segregating for a single locus insertion were identified and used for disease resistance assays. Transgenic tobacco plants exhibited high levels of Rhizoctonia resistance in detached leaf assays. Similarly, transgenic Arabidopsis seedlings were resistant to the fungus and prevented damping off symptoms. Use of lactoferrin gene is a potential new approach to consider for control of diseases caused by fungal pathogens.
Klippel-Trenaunay Syndrome and Spinal Arteriovenous Malformations: An Erroneous Association (2010)

An association between KTS and spinal AVM, as posited in numerous references, is most likely erroneous. The association has neither been reliably proved in the limited published literature nor encountered in a large cohort.