gebhart/patrepeval huggingface dataset:
Vitamin C Supplementation Does Not Alter the Immune Response to 2.5 Hours of Running (1997)

This randomized, double-blind, placebo-controlled study was designed to determine the influence of vitamin C supplementation on the immune response to 2.5 hr of high-intensity running. Twelve experienced marathon runners (VO2 max 51.6 +/- 1.5 ml.kg-1.min-1, age 40.5 +/- 2.0 years) were randomized into vitamin C (1,000 mg/day for 8 days) or placebo groups. On the test day, subjects ran at 75-80% VO2 max for 2.5 hr, with five blood samples taken before and for 6 hr after. Blood samples were analyzed for cortisol and catecholamines; leukocyte subsets; interleukin-6; natural killer cell activity; lymphocyte proliferation as induced by concanavalin A, phytohemagglutinin, and pokeweed mitogen; and granulocyte phagocytosis and activated oxidative burst. Compared with placebo, vitamin C supplementation had no significant effect on the pattern of change in any of these hormonal or immune measures following 2.5 hr of intensive running.
Signal processing and waveform generation in the side zone automotive radar (2002)

Recently, a "Side Zone" automotive radar, also known as the Side Detection System (SDS), has been introduced. The radar has a significant amount of signal processing aimed at tracking targets, estimating ground speed, and rejecting clutter. Introductory papers give an overview of the radar including performance requirements, requirements analysis, architecture design, signal processing, block diagrams, and test result summaries. This paper is primarily concerned with, and expands on, the signal processing techniques used in the SDS radar. Also, the method of waveform generation is described in detail, as it is intricately related to the radar signal processing.
Exchange-Coupled Magnetic Bilayer Media for Thermomagnetic Writing and Flux Detection (1999)

We have newly developed a perpendicular thermomagnetic recording coupled with magnetic flux detection. Conventional magneto-optical thin films with TbFeCo compensation compositions are advantageous for thermomagnetic writing, but insufficient for magnetic flux detection due to low flux density at room temperature. We therefore designed magnetically exchange-coupled bilayer media suitable for flux detection by adding a magnetic layer with high flux density to a conventional TbFeCo magnetic recording layer.
Compressed Gaussian process for manifold regression (2016)

Nonparametric regression for large numbers of features (p) is an increasingly important problem. If the sample size n is massive, a common strategy is to partition the feature space, and then separately apply simple models to each partition set. This is not ideal when n is modest relative to p, and we propose an alternative approach relying on random compression of the feature vector combined with Gaussian process regression. The proposed approach is particularly motivated by the setting in which the response is conditionally independent of the features given the projection to a low dimensional manifold. Conditionally on the random compression matrix and a smoothness parameter, the posterior distribution for the regression surface and posterior predictive distributions are available analytically. Running the analysis in parallel for many random compression matrices and smoothness parameters, model averaging is used to combine the results. The algorithm can be implemented rapidly even in very large p and moderately large n nonparametric regression, has strong theoretical justification, and is found to yield state of the art predictive performance.
Data from Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Neoadjuvant chemotherapy prior to definitive surgery has been used widely for locally advanced oral squamous cell carcinoma (OSCC). We evaluated neoadjuvant erlotinib with platinum-docetaxel versus placebo with platinum-docetaxel in patients with stage III–IVB OSCC.&lt;/p&gt;Patients and Methods:&lt;p&gt;Patients with newly diagnosed stage III, IVA, and IVB (American Joint Committee on Cancer 7th) OSCC amenable to surgical resection were included. Patients were randomized to receive up to 3 cycles of chemotherapy with concurrent erlotinib or placebo, followed by surgery. The primary endpoint was major pathologic response (MPR) rate; secondary endpoints included safety, overall survival (OS), and progression-free survival (PFS).&lt;/p&gt;Results:&lt;p&gt;Fifty-two patients received at least 1 cycle of treatment and 47 were evaluable with surgical resection. MPR rate was not different between erlotinib (30%, 7/23) and placebo arms (41.7%, 10/24; &lt;i&gt;P&lt;/i&gt; = 0.55). At median follow up of 26.5 months, there was no difference on OS or PFS between groups. Patients who received erlotinib with chemotherapy and achieved MPR (&lt;i&gt;n&lt;/i&gt; = 7) had no recurrence. The treatment-related adverse event rates were not different between the two groups (96% vs. 96%). However, rash, mostly low grade, was more common in the erlotinib arm (79% vs. 50%). Transcriptomic analysis in the pretreatment samples indicated that genes in protein glycosylation and Wnt signaling pathways were associated with benefit in those treated with erlotinib plus chemotherapy.&lt;/p&gt;Conclusions:&lt;p&gt;The addition of erlotinib to platinum-taxane chemotherapy was well tolerated but did not induce higher rates of MPR or PFS or OS survival benefit. Patients who received chemotherapy with erlotinib and achieved major pathologic responses had excellent clinical outcome.&lt;/p&gt;&lt;/div&gt;
Enhancing effect of Panax ginseng on Zip4-mediated zinc influx into the cytosol (2021)

<i>P. ginseng</i> extract induced Zip4 expression at the mRNA and protein level and resulted in higher zinc uptake in Hepa cells. Some ginsenosides facilitated zinc influx. On the basis of these results, we suggest a novel effect of <i>P. ginseng</i> on Zip4-mediated zinc influx, which may provide a new strategy for preventing zinc deficiency.
Aerosols released during the laser cutting of a Fukushima Daiichi debris simulant (2019)

International audience
Vitrification of zebrafish embryo blastomeres in microvolumes. (2008)

Cryopreservation of fish embryos may play an important role in biodiversity preservation and in aquaculture, but it is very difficult. In addition, the cryopreservation of fish embryo blastomeres makes conservation strategies feasible when they are used in germ-line chimaerism, including interspecific chimaerism. Fish embryo blastomere cryopreservation has been achieved by equilibrium procedures, but to our knowledge, no data on vitrification procedures are available. In the present work, zebrafish embryo blastomeres were successfully vitrified in microvolumes: a number of 0.25 microl drops, sufficient to contain all the blastomeres of an embryo at blastula stage (from 1000-cell stage to oblong stage), were placed over a 2.5 cm loop of nylon filament. In this procedure, where intracellular cryoprotectant permeation is not required, blastomeres were exposed to cryoprotectants for a maximum of 25 sec prior vitrification. The assayed cryoprotectants (ethylene glycol, propylene glycol, dimethyl sulphoxide, glycerol and methanol) are all frequently used in fish embryo and blastomere cryopreservation. Methanol was finally rejected because of the excessive concentration required for the vitrification (15M). All other cryoprotectants were prepared (individually) at 5 M in Hanks' buffered salt solution (sigma) plus 20% FBS (vitrification solutions: vs). After direct thawing in Hanks' buffered salt solution plus 20% FBS, acceptable survival rates were obtained with ethylene glycol: 82.8%, propylene glycol: 87.7%, dimethyl sulphoxide: 93.4%, and glycerol: 73.9% (p < 0.05). Dimethyl sulphoxide showed the highest blastomere survival rate and allowed the rescue of as much as 20% of the total blastomeres from each zebrafish blastula embryo.
PO 8518 LATENT TUBERCULOSIS INFECTION DETECTION BY IGRA USING MYCOBACTERIUM TUBERCULOSIS ALTERNATIVE DESATURASE A1 IMMUNE-DOMINANT ANTIGEN (2019)

Background Despite an efficient treatment and a widely-used vaccine, one third of the world’s population is estimated to be latently infected (LTBI) with Mycobacterium tuberculosis (Mtb) and are at risk of progressing to contagious active tuberculosis. New TB vaccines and improved detection of LTBI are therefore urgently required for global TB control. As a first step towards these goals, a better understanding of host recognition and response to immunogenic Mtb antigens is needed. Methods In this study, interferon-γ release in response to the immunodominant antigens ESAT-6, TB10.4, Ag85A, Rv2031 and DesA1 was assessed by ELISPOT on PBMC from 55 newly diagnosed pulmonary TB patients, 121 of their household contacts and 123 matched community controls, enrolled in a high-burden area. Results ESAT-6 and PPD ELISPOT responses were higher in the TB patient group compared to both contacts and controls (p&lt;0.05 repectively). These responses increased with time after recruitment in the contacts and fell after successful treatment in the patients consistent with the hypothesis that responses to these antigens reflect antigenic or bacterial load. However, the response to DesA1 was significantly lower in the controls compared to the contacts (p&lt;0.05 respectively). Receiver Operating Characteristic curve analysis showed that PPD/ESAT-6 best segregated TB patients from the other groups, while DesA1 best segregated contacts from controls. Conclusion The present study therefore identifies DesA1 as an immunodominant antigen with the potential to contribute to improved immunodiagnosis.
IC‐P‐054: A quadratic P‐spline mixed model to predict cognitive decline in Alzheimer's disease (2013)

Deciphering the longitudinal trajectory of AD biomarkers would enhance our capacity for early diagnostic and prediction of disease progression. Our purpose was to study hippocampal volumes (HC) and FDG-PET metabolism trajectories based on either MMSE or ADAS-Cog scores as putative markers of clinical disease progression. Assuming the biomarker hypothesis proposed by Jack et al., we thus elicited to use a smoothing spline mixed effects model to predict the evolution of longitudinal biomarkers as a function of neuropsychological scores. We selected a total of 734 subjects who had at least two visits within a 36-month follow-up from ADNI: 167 probable AD patients, 136 MCI having progressed to probable AD within that timeframe (pMCI), 224 MCI subjects that remained clinically stable (sMCI), and 207 controls that remained clinically stable (sCRT). We extracted MMSE, ADAS-cog, HC volumes and FDG PET metabolism from the ADNI database. For modeling purposes we used the average of left and right HC volumes. We used a smoothing quadratic spline mixed effects model to describe and evaluate disease progression, from sCRT to sMCI, to pMCI and finally AD subjects. Cut-off points for each group, where the random effect was defined, were chosen as the mean MMSE and ADAS-Cog score per group. Baseline demographics information can be found in Table 1, with p -values obtained from F and Chi-square tests. We plotted individual profiles modified by the cut-off scores and the mean profile evolution of biomarkers versus MMSE and ADAS-cog for males and females in Figure 1.
Rescue of functional delF508‐CFTR channels in cystic fibrosis epithelial cells by the α‐glucosidase inhibitor miglustat (2006)

In the disease cystic fibrosis (CF), the most common mutation delF508 results in endoplasmic reticulum retention of misfolded CF gene proteins (CFTR). We show that the alpha-1,2-glucosidase inhibitor miglustat (N-butyldeoxynojirimycin, NB-DNJ) prevents delF508-CFTR/calnexin interaction and restores cAMP-activated chloride current in epithelial CF cells. Moreover, miglustat rescues a mature and functional delF508-CFTR in the intestinal crypts of ileal mucosa from delF508 mice. Since miglustat is an orally active orphan drug (Zavesca) prescribed for the treatment of Gaucher disease, our findings provide the basis for future clinical evaluation of miglustat in CF patients.
Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery (2014)

Patients undergoing cardiac surgery require adequate myocardial protection. Manipulating myocardial metabolism may improve the extent of myocardial protection. Perhexiline has been shown to be an effective anti-anginal agent due to its metabolic modulation properties by inhibiting the uptake of free fatty acids into the mitochondrion, and thereby promoting a more efficient carbohydrate-driven myocardial metabolism. Metabolic modulation may augment myocardial protection, particularly in patients with left ventricular hypertrophy (LVH) known to have a deranged metabolic state and are at risk of poor postoperative outcomes. This study aimed to evaluate the role of perhexiline as an adjunct in myocardial protection in patients with LVH secondary to aortic stenosis (AS), undergoing an aortic valve replacement (AVR).
Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis (2010)

Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical practice today. It is widely believed that functional and structural abnormalities of the gastroesophageal junction as well as an abnormal exposure to gastroduodenal contents are the main contributors to its pathogenesis. Novel findings of the inflammatory process in GERD suggest a far more complex process involving multifaceted inflammatory mechanisms. This review summarizes knowledge about the expression of inflammatory mediators in GERD and their potential cellular sources and provides an integrated concept of disease pathogenesis. In addition we evaluate the contribution of inflammatory mediators to well-known complications of GERD, namely motility abnormalities, fibrosis, and carcinogenesis. Novel findings regarding the pathophysiology of esophageal inflammation should enhance our understanding of GERD and its complications and provide new treatment insights.
Intelligent dialog overcomes speech technology limitations (2003)

We present a primarily speech-based user interface to a wide range of entertainment, navigation and communication applications for use in vehicles. The multimodal dialog en ables the system to uniquely identify one of 79,000 place name variants using an active vocabulary of only 3,000 words at any given time. Low confidence in speech recog nition and word-level ambiguities are compensated for in flexible clarification dialogs with the user. The underlying dialog concept was developed in the framework of the EU-project SENECa. Some recent evalua tion results of the SENECa system demonstrator are discussed in the paper
BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing (2016)

BRCA mutated ovarian cancers respond better to platinum-based therapy and to the recently approved PARP-inhibitors. There is the need for efficient and timely methods to detect both somatic and germline mutations using formalin-fixed paraffin-embedded (FFPE) tissues and commercially available technology. We used a commercial kit exploring all exons and 50bp exon-intron junctions of BRCA1 and BRCA2 genes, and semiconductor next-generation sequencing (NGS) on DNA from 47 FFPE samples of high-grade serous ovarian cancers. Pathogenic mutations were found in 13/47 (28%) cancers: eight in BRCA1 and five in BRCA2. All BRCA1 and two BRCA2 mutations were germline; three BRCA2 mutations were somatic. All mutations were confirmed by Sanger sequencing. To evaluate the performance of the NGS panel, we assessed its capability to detect the 6,953 variants described for BRCA1 and BRCA2 in ClinVar and COSMIC databases using callability analysis. 6,059 (87.1%) variants were identified automatically by the software; 829 (12.0%) required visual verification. The remaining 65 (0.9%) variants were uncallable, and would require 15 Sanger reactions to be resolved. Thus, the sensitivity of the NGS-panel was 99.1%. In conclusion, NGS performed with a commercial kit is highly efficient for detection of germline and somatic mutations in BRCA genes using routine FFPE tissue.
Electrooptic Constant of Cadmium Telluride (1967)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text O. M. Stafsudd, F. A. Haak, and K. Radisavljević, "Electrooptic Constant of Cadmium Telluride," Appl. Opt. 6, 1276-1276 (1967) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The determination of free and protein-bound haemoglobin in plasma using a combination of HPLC and absorption spectrometry. (2001)

The aim of the study was to develop a method for the determination of haemoglobin in plasma suitable for use to set target values for external quality assessment schemes for this analyte using commercially available test kits and equipment. In the early phase of the method development it became clear that the use of a single method, namely HPLC, would not be possible. However, by combining HPLC and absorption spectrophotometry, both qualitative and quantitative rapid determinations of protein-bound and free haemoglobin were able to be performed on equipment present in most routine clinical chemistry laboratories. The separation of protein-bound and free haemoglobin could be carried out using commercial HPLC equipment for the determination of haemoglobin A1c (HbA1c) without modification of the conditions used. Instead of haemolysed blood, the same volume of plasma (10 microl) was injected. The eluate was not discarded, but collected in 1-minute fractions so that the void volume (protein-bound Hb) and the haemoglobin peaks (free Hb) were available for the colorimetric determination of haemoglobin using the pseudoperoxidase activity of the haem moiety on hydrogen peroxide and a chromogen (3,3',5,5'-tetramethylbenzidine) in concentrated acetic acid and optimal determination at 600 nm. (In this publication at 578 nm due to the use of a spectrophotometer with Hg-discharge lamp and filter). The appearance of a blue colour in the reaction tube or cuvette indicated the presence of haemoglobin. The use of the above chromogen, with its absorption maximum around 600 nm excluded interference from serum components such as bilirubin, which may interfere in the conventional method often used to determine plasma haemoglobin. The method can be used quantitatively by including an aqueous human haemoglobin standard in the run. This elutes from the HPLC column only as free haemoglobin in the concentration range from 0.1 to 10 g/l. Addition of human haemoglobin to haemoglobin-free plasma resulted in the binding of all Hb to plasma proteins up to a concentration between 2 and 3 g/l (void-volume fraction). At higher concentrations free Hb appeared in the 3-5 minute fractions. These observations agree with published data on the scavenging capacity of plasma for Hb released from erythrocytes. The method is rapid, (HPLC-run maximally 6 min, quantitative colorimetric results 5-10 min) precise (inter-assay coefficients of variation < 8%) and suitable for answering the question as to whether the protein-binding (scavenging) system which prevents the nephro- and cerebrotoxic effects of haemoglobin has been saturated or not, an important question in patients with acute haemolysis problems. A qualitative result is obtainable within 10 minutes of injecting the sample into the HPLC-system. The use of this assay in controlling blood transfusion and haemolytic events arising from surgery, intravascular haemolytic bacteria or artificial heart valves can help in rapid corrective action, if needed.
Useful Host-Vector Systems in Bacillus stearothermophilus (1988)

We isolated a highly transformable thermophile, Bacillus stearothermophilus SIC1, which exhibited the following features. The growth temperature ranged from 45 to 65 degrees C in L broth. The maximum cell concentration in 2L broth (2% tryptone, 1% yeast extract, 0.5% NaCl, pH 7.2) was determined as an optical density at 660 nm of 7.8, and the generation time was 11 min at 60 degrees C. Strain SIC1 was a prototroph and was transformed by the protoplast procedure not only with repB plasmids (high-copy-number plasmids such as pTB913 and pUB110) but also with repA plasmids (low-copy-number plasmids such as pTB53). Transformation efficiencies with repB and repA plasmids were about 2 x 10 to 5 x 10 and 5 x 10 transformants per mug of DNA, respectively. The transformant carrying plasmid pTB913Y/K could grow at 63 degrees C in the presence of kanamycin. The regeneration frequency of protoplasts was 60%, and only 1 day was needed for regeneration at 55 degrees C.
A Retrospective Analysis for Different Routes of Administration in Mice-Percutaneous Retro-Orbital, Jugular Catheter, Tail Vein and Femoral Cut Down Injections (2020)

Liposomes effectively transport fatty proteins to targeted tissues. Laboratory experiments use multiple methods to administer liposomes, but comparison of these methods is not available. In this retrospective study, we characterized and compared four intravenous administration routes (tail vein, jugular catheter, femoral vein and percutaneous retro-orbital injections) in murine models. ApoE-/- mice were used to compare administration routes. Results indicate that the jugular catheter route delivered the highest amount of liposomes to tissues due to longer period of injections compared to other routes; however, this route failed to remain patent for 8/10 animals. Delivery via tail vein, femoral vein and percutaneous retro-orbital injections resulted in similar accumulation in the organs. When including technical difficulty and expense, percutaneous retro-orbital injections of liposomes are the most convenient and efficacious approach.
Simulating Solid-Solid Phase Transition in Shape-Memory Alloy Microstructure by Face-Offsetting Method (2008)

Advances in the understanding of martensitic transformations (diffusionless, solid‐solid phase transformations) have been instrumental to the recent discovery of new low hysteresis alloys. However, some key fundamental issues must be better understood to design still better alloys. Restricting attention to antiplane shear, we use finite element analysis to model the shape‐memory alloy microstructure within the Abeyaratne‐Knowles continuum thermomechanical framework and use an interface kinetic relation of the kind proposed by Rosakis and Tsai. Geometric singularities and topological changes associated with microstructural evolution pose significant numerical challenges. We address such challenges with a recently developed front‐tracking scheme called the face‐offsetting method (FOM) to explicitly model phase interfaces. Initial results demonstrate the effectiveness of FOM in resolving needle‐like twinned microstructures.
Temperature Dependence of the Zero-Field Splitting of Cr3+ Ions in CsAl(SO4)2∙12H2O (1974)

The zero-field splitting of Cr 3+ ions in CsAl(SO 4 ) 2 ∙12H 2 O was studied in the temperature range 4.2 to 300 K. The experimental spectrum is described with a spin Hamiltonian with S = 3/2 and g = 1.975 ± 0.005; the zero-field splitting parameter D changes with temperature having a value of −0.074 ± 0.0003 cm −1 at room temperature and a value of −0.070 ± 0.0003 cm −1 at liquid helium temperature.