gebhart/patrepeval huggingface dataset:
H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo (1998)

H-cadherin is a newly characterized cadherin molecule whose expression is decreased in a variety of human carcinoma cells, suggesting that it may play a role in maintaining normal cellular phenotype. To investigate how re-expression of H-cadherin could influence the malignant phenotype of human breast carcinoma cells in vivo, we transfected both control and H-cadherin expression vectors into human breast cancer cells (MDAMB435), which do not express H-cadherin constitutively. We found that invasiveness of these cells could be prevented by transfection with H-cadherin. We also compared the ability of control- and H-cadherin-transfected cells to induce subcutaneous tumors after injection into mammary fat pads of nude mice. Our results show that H-cadherin transfection produced a marked inhibition of tumor growth and modified the morphology of tumor cells: tumors from mice injected with control cells were significantly larger and contained larger cells having a higher degree of pleomorphism than those of tumors generated from carcinoma cells expressing H-cadherin. Altogether, these results indicate that H-cadherin expression antagonizes tumor growth in nude mice, presumably by enhancing cell-cell association in a tissue environment. These findings strongly suggest that H-cadherin could provide a possible target for corrective gene therapy against breast cancer.
Battery Charge Control With an Electro-Thermal-Aging Coupling (2015)

Efficient and safe battery charge control is an important prerequisite for large-scale deployment of clean energy systems. This paper proposes an innovative approach to devising optimally health-conscious fast-safe charge protocols. A multi-objective optimal control problem is mathematically formulated via a coupled electro-thermal-aging battery model, where electrical and aging sub-models depend upon the core temperature captured by a two-state thermal sub-model. The Legendre-Gauss-Radau (LGR) pseudo-spectral method with adaptive multi-mesh-interval collocation is employed to solve the resulting highly nonlinear six-state optimal control problem. Charge time and health degradation are therefore optimally traded off, subject to both electrical and thermal constraints. Minimum-time, minimum-aging, and balanced charge scenarios are examined in detail. The implications of the upper voltage bound, ambient temperature, and cooling convection resistance to the optimization outcome are investigated as well.
On Semantic Update Operators for Answer-Set Programs (2010)

Logic programs under the stable models semantics, or answer-set programs, provide an expressive rule based knowledge representation framework, featuring formal, declarative and well-understood semantics. However, handling the evolution of rule bases is still a largely open problem. The AGM framework for belief change was shown to give inappropriate results when directly applied to logic programs under a nonmonotonic semantics such as the stable models. Most approaches to address this issue, developed so far, proposed update operators based on syntactic conditions for rule rejection.
Synthesis of a β‐Mannosyl‐Chitobiosyl‐Asparagine Conjugate—a Central Core Region Unit of the N‐Glycoproteins (1990)

The correct β-glycosidic linkage between mannose and chitobiosyl-asparagine residues in N-glycoproteins was achieved synthetically for the first time in the construction of 1. Decisive is the intramolecular nucleophilic substitution in 2; the product of this reaction was transformed, via a trisaccharide and a trisaccharide isothiocyanate, into the asparagine derivative 1.
Cell‐specific ATP7A transport sustains copper‐dependent tyrosinase activity in melanosomes (2009)

Copper is a cofactor for many cellular enzymes and transporters. To be loaded onto secreted and endomembrane cuproproteins, copper is translocated from the cytosol into membrane‐bound organelles by one of two transporters, ATP7A or ATP7B, the genes for which are mutated in the copper imbalance syndromes, Menkes and Wilson disease, respectively. Endomembrane cuproproteins are thought to stably incorporate copper upon transit through the trans Golgi network (TGN), within which ATP7A and ATP7B accumulate in most cells by dynamic cycling through early endocytic compartments. Here we show that the pigment cell‐specific cuproenzyme tyrosinase acquires copper only transiently within the TGN of melanocytes. To catalyze melanin synthesis, tyrosinase must be subsequently reloaded with copper within specialized pigment organelles called melanosomes. Copper is supplied to melanosomes by ATP7A, a cohort of which localizes to melanosomes in a Biogenesis of Lysosome‐related Organelles Complex‐1 (BLOC‐1)‐dependent manner. These results indicate that cell type‐specific localization of a metal transporter is required to sustain metallation of an endomembrane cuproenzyme, providing a mechanism for exquisite cell type‐specific spatial control of metalloenzyme activity. Moreover, as BLOC‐1 subunits are mutated in subtypes of the genetic disease, Hermansky‐Pudlak syndrome (HPS), these results also show that defects in copper transporter localization contribute to hypopigmentation, and hence perhaps other systemic defects, in HPS.
Cardiovascular Effects of Sustained Norepinephrine Infusions. I. Hemodynamics (1966)

Norepinephrine (NE) in graded doses of 1, 2, and 4 µg/kg/min was infused for four hours into 14 dogs; 5 dogs served as controls. The systemic pressure and flow, blood volume, hematocrit, arterial blood pH, and oxygen saturation were measured at selected intervals throughout the infusion period. Cardiovascular performance was augmented during the first 15 minutes of the NE infusions, but this effect was not sustained. Thereafter, there was a dose-related decline in cardiac output, systemic pressure and left ventricular work, and an increase in the calculated peripheral vascular resistance. At the highest NE dose rate employed, significant left ventricular failure developed by the second hour of NE administration. The hematocrit increased during the first 15 minutes of NE infusion and remained elevated throughout the infusion period. Sustained hypovolemia was not found during the prolonged NE administration, and severe acidosis (pH &lt; 7.20) was inconstant. The processes which lead to cardiovascular dysfunction during prolonged NE infusion are discussed.
A Simple Strip Model in the Volume-Surface Integral Equation for Analysis of Arbitrary Probe-Fed Conformal Microstrip Antennas (2009)

A strip model is incorporated in the volume-surface integral equation (VSIE) to simplify the analysis of the probe-fed conformal microstrip antennas (CMSAs) with arbitrary shapes. The thin wire-surface junction of the feeding probe and the patch is transferred to the surface-surface junction that can be modeled by using Rao-Wilton-Glisson (RWG) basis functions easily. Thus, the use of complicated attachment mode basis function in the conventional VSIE is eliminated, which simplifies the calculation of the method-of-moments (MoM) matrix. The construction of RWG basis functions at the surface-surface junction is detailed as well. An effective remedy is also proposed to overcome the computation breakdown in the near-singularity treatment when the field point locates at the extension of one side of the source domain. Numerical results show the reliability and accuracy of the proposed method.
Customizable Routing with Declarative Queries (2004)

To meet the demands of new Internet applications, recent work argues for giving end-hosts more control over routing. To achieve this goal, we propose the use of a recursive query language, which allows users to define their own routing protocols. Recursive queries can be used to express a large variety of route requests such as the k shortest paths, shortest paths that avoid (or include) a given set of nodes and least-loaded paths. We show that these queries can be e#ciently implemented in the network, and in the simple case when all users request shortest paths, the communication overhead of our solution is similar to that incurred by a distance vector protocol. In addition, when only a subset of nodes issue the same query, the communication cost can be further lowered using automatic query optimization techniques -- suggesting that declarative queries and automatic optimization are important in this domain. Finally, we outline the main challenges faced by our proposal, focusing on the expressiveness and e#ciency of our proposal.
Dynamic Contrast-enhanced Area-detector CT vs Dynamic Contrast-enhanced Perfusion MRI vs FDG-PET/CT: Comparison of Utility for Quantitative Therapeutic Outcome Prediction for NSCLC Patients Undergoing Chemoradiotherapy (2019)

Dynamic first-pass CE-perfusion ADCT and MR imaging as well as PET/CT are useful for early prediction of treatment response by NSCLC patients treated with chemoradiotherapy.
Effect of Sawdust or Acid Application to Pen Surfaces on Nitrogen Losses from Open-Dirt Feedlots (2002)

Two nutrient management treatments (sawdust or sulfuric acid application to pen surface) were compared to conventional management using 12 pens (10 steers/pen) to determine effects on performance and nitrogen losses from pens. Performance and carcass characteristics for treatments were similar to the control. The sawdust treatment retained more nitrogen in manure when removed from the pen surface and after composting. Increasing carbon by sawdust additions reduced nitrogen losses by 21%. Applying acid to the pen surface did not affect quantity of nitrogen or organic carbon conserved in manure and compost.
423 Investigation on a Novel Snow-Melting System with Low Temperature Waste heat of Fuel Cell (2007)

Fuel cell system is expected to be useful for prevention of global warming and decrease in the usage of fossil fuels. Exhaust heat utilization is important to fuel cell system in order to improve the general efficiency to the maximum level. The study suggests that a room heating and slow melting system utilize the exhaust heat from polymer electrolyte fuel cell (PEFC) and aims at developing the novel heat utilization system Experiments on a prototype system were conducted to investigate the system performance. As there was little snow in the winter of 2006, not enough experimental results were available to fully evaluate the performance of snow melting system. Nevertheless, the results show the PEFC system with snow melting system is effective in snowy cold region; the heat demand of melting snow will improve the general efficiency of PEFC.
Immune infiltrates in liver metastases of colorectal cancer and response to chemotherapy (2009)

e15069 Background: Colorectal cancer (CRC) is a major cause of death from cancer. Patients with irresectable or metastasized CRC usually receive chemotherapy in combination with a monoclonal antibody, median overall survival time is around 20- 21 months with response rates of around 50%. Almost half of the patients experience treatment related side effects without benefit. K-ras mutation is the only (negative) predictive marker for response to therapy (for EGFR-targeting antibody treatment), no biomarkers are available that help to select patients most likely responding to chemotherapy. In primary colon cancer immune infiltrates in the tumor represent an important prognostic factor. High densities of tumor infiltrating lymphocytes (TIL) were shown to be correlated with an improved survival in patients with primary CRC. TILs therefore represent a valuable prognostic tool, a high density of immune cells being associated with good outcome independently of other established prognostic markers. Little is known about an association between these immune cells and the response to chemotherapy. Methods: Here the relation between infiltrates of immune cells in liver metastases of CRC and the response to chemotherapy (using immunohistochemical staining against CD8, GranB, FOXP3, CD45RO, etc.) was investigated. Samples from 33 patients with metastasized colorectal cancer (samples from 22 patients were used as training set and samples from 11 patients as validation set) were analyzed. Results: The evaluation of positively stained TIL in the invasive margin of the liver metastasis allowed to predict response to chemotherapy. This was also observed in the analysis of the time to progression, where higher numbers of positively stained cells were associated with longer intervals. The difference between the groups with either response or no response to chemotherapy in time to progression was statistically significant in the analyzed sets (Mann-Whitney- U, p&lt;0.001, two-tailed, z=-3,961, n=33). In primary tumors no association between TIL densities and response to chemotherapy was observed. Conclusions: Our results suggest that the immune system has an important impact on the efficacy of chemotherapy and the presented data will have implications for the assessment of therapy options. No significant financial relationships to disclose.
Selective ethenolysis and oestrogenicity of compounds from cashew nut shell liquid (2014)

First generation Ru catalysts are the best for ethenolysis of cardanol to 3-non-8-enylphenol, a precursor to 3-nonylphenyl (3-NP) a potential replacement for the banned 4-nonylphenol (4-NP). The oestrogenicity of 3-NP is reduced by a factor of 150 compared with 4-NP.
Design of dual polarized antenna for DCS, UMTS, WiBro base stations (2010)

In this paper, we proposed the dual polarization antenna for DCS, UMTS, and WiBro bands. To extend the impedance band width, the proposed antenna used the square loop radiators. In addition, by square loop radiators, the dimensions of an antenna are reduced. As a result of measurement after compensation, we can see that the first port is less than −14dB, the second port is less than −14dB and intra isolation is less than −25dB. Additionally, a gain of the antenna is more than 9dBi. This polarization diversity antenna element can be used to form an array antenna for a wireless communication base station.
The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1 (2014)

Single-stranded DNA (ssDNA) at DNA ends is an important regulator of the DNA damage response. Resection, the generation of ssDNA, affects DNA damage checkpoint activation, DNA repair pathway choice, ssDNA-associated mutation and replication fork stability. In eukaryotes, extensive DNA resection requires the nuclease Exo1 and nuclease/helicase pair: Dna2 and Sgs1(BLM). How Exo1 and Dna2-Sgs1(BLM) coordinate during resection remains poorly understood. The DNA damage checkpoint clamp (the 9-1-1 complex) has been reported to play an important role in stimulating resection but the exact mechanism remains unclear. Here we show that the human 9-1-1 complex enhances the cleavage of DNA by both DNA2 and EXO1 in vitro, showing that the resection-stimulatory role of the 9-1-1 complex is direct. We also show that in Saccharomyces cerevisiae, the 9-1-1 complex promotes both Dna2-Sgs1 and Exo1-dependent resection in response to uncapped telomeres. Our results suggest that the 9-1-1 complex facilitates resection by recruiting both Dna2-Sgs1 and Exo1 to sites of resection. This activity of the 9-1-1 complex in supporting resection is strongly inhibited by the checkpoint adaptor Rad9(53BP1). Our results provide important mechanistic insights into how DNA resection is regulated by checkpoint proteins and have implications for genome stability in eukaryotes.
553-GHz signal generation in CMOS using a quadruple-push oscillator (2011)

A 553-GHz quadruple-push oscillator is demonstrated using low leakage transistors in 45-nm CMOS. The currents of coupling transistors of a quadrature oscillator were summed up to implement quadruple pushing. Quasi-optical measurements showed that the circuit generates 4th harmonic signal at 553 GHz with the power level of 220 nW, while suppressing unwanted harmonic signals. The circuit consumes 64 mW from a 1.4 V supply.
Apfel’s apples: A generation of scientists trained at Yale (2007)

Bob Apfel taught at Yale University for over thirty years, advising scores of students during that time. Prior to Yale, Bob trained at Harvard University with Frederick Hunt and the chain of advisors can be loosely traced back, all at Harvard, to 1802. During his time at Yale, Bob graduated 28 Ph.D.’s and trained 12 post-doctoral students in addition to the numerous undergraduates that he advised. Many of the students moved on to become professors themselves and, following the lead of Bob, many are very active in the Acoustical Society of America.
Fabrication of Cell-Encapsulated Alginate Microfiber Scaffold Using Microfluidic Channel (2008)

Abstract Traditional approaches in tissue engineering are limited in that cell seeding is inefficient and cells cannot be located on a scaffold precisely. Moreover, the traditional methods, which rely on a random and probabilistic process, produce scaffolds with low regularity in porosity, pore size, and interconnection of pores. In this research, we propose a novel method to fabricate a scaffold for tissue engineering, which can overcome the limitations of traditional approaches. Cell-encapsulated alginate solution and cross-linker solution were laminarly flowed into a microfluidic channel. Then, the alginate solution was gelled to form a cell-encapsulated alginate microfiber by the diffusion of gelation ion from the cross-linker solution and ejected from the outlet of channel to the reservoir. The diameter of the fabricated microfiber can be controlled by the flow rate ratio of the two solutions. Moreover, this method, which has no cell seeding step, eliminates the possibility of loss of cells and the problems related to distribution of cells. We also show the feasibility of the alginate microfiber as a scaffold, which can promote chondrogenesis. The chondrogenesis in the alginate microfiber was evaluated by both histological and biochemical analyses. The increase of major markers of chondrogenesis such as glycosaminoglycan and collagen shows the potential of alginate microfiber as a scaffold for cartilage.
Position-independent and copy-number-related expression of a goat bacterial artificial chromosome α-lactalbumin gene in transgenic mice (1999)

A bacterial artificial chromosome goat insert comprising the α-lactalbumin-encoding transcription unit with approximately 150 and 10 kb of 5´- and 3´-flanking sequences, respectively, was micro-injected into mouse eggs. In six out of seven transgenic lines, the level of mammary tissue- and stage-specific expression was position-independent and copy-number-dependent. The exogenous α-lactalbumin yield, about 0.8 mg/ml of milk per copy, compared favourably with the α-lactalbumin content of mouse and goat milks, about 0.8 and > 1 mg/ml, respectively. This suggests that the insert contains most if not all of the cis-acting elements involved in the full and specific expression of the goat α-lactalbumin gene and opens up opportunities to use this vector to target expression of foreign genes in the lactating mammary gland of transgenic animals. The transgene was silent in the seventh line for an unknown reason.
Continuous wave photon pair generation in silicon-on-insulator waveguides and ring resonators : erratum (2010)

An error was made which is a basic calculation mistake. We have corrected this error and updated the prospects about ring cavity-based photon pair sources. (C) 2010 Optical Society of America
Assessment Of Handling Qualities For The Shipborne Recovery Task - ADS 33 (Maritime) (2000)

Peer reviewed: Yes
Heightening upper limit frequency of wideband antenna using asymmetrical radiating elements (2015)

In recent years, cognitive radio system is receiving particular attention as a promising technology in order to materialize efficient network access. In this paper, heightening upper limit frequency of the wideband antenna for cognitive radio system was investigated by employing three types of the antenna element variations. As a result, the antenna, employing asymmetrical elements, with the VSWR less than 2.0 in the frequency range of 3.1 GHz to 18 GHz was obtained. As for the radiation patterns, although the slightly distorted radiation patterns due to employing the asymmetrical elements were observed, it is acceptable in practical use.
Removal of organics from offshore produced waters using nanofiltration membrane technology (1990)

Abstract The separation of oil and produced water mixtures from oil and gas producing wells has traditionally been accomplished by gravity settlers (e.g., multi‐phase separators, skimmers, and flotation cells). However, current EPA regulations on the organic content of discharged produced water have reached the limits of these separation techniques. The industry is in need of new technologies to treat these waters. One such technology that we have found promissing is organics/water separation by nanofiltration membranes.
Application of new methane linelists to Cassini and Earth-based data of Titan (2011)

International audience
Optic sharp edge or convexity: comparison of effects on posterior capsular opacification. (1996)

Posterior capsular opacification was evaluated in 46 eyes with an implanted sharp-edged biconvex (BC) lens, 108 eyes with the sharp-edged convex-plano (CP) lens, 160 eyes with the round-edged BC lens and 58 eyes with the round-edged CP lens. In each eye, the intraocular lens had been fixed in the sac after continuous circular capsulorrhexis, with the optic edge completely enclosed by the anterior capsule. Two years postoperatively, the posterior capsules of these eyes were photographed and the degree of opacification was classified as Grade 1 (clear) to Grade 4 (severely opacified). In the sharp-edged BC group, 91% of the eyes were Grade 1; 4% Grade 2; 2% Grade 3; 2% Grade 4. In the sharp-edged CP group, the corresponding percentages were 83, 7, 4, and 6; for the round-edged BC group: 18, 27, 24, and 31; and for the round-edged CP group: 34, 17, 28, and 21. These findings suggest that the most significant factor in prevention of posterior capsular opacification is the sharpness of the optic edge. We believe that the sharp optic edge creates higher pressure on the posterior capsule and acts as a barrier to lens epithelial cell migration.
The new era of scaling in an SoC world (2009)

The time has passed when traditional MOSFET scaling techniques were adequate to meet the needs of microprocessor products, but that has not meant the end of Moore's Law nor the end of improvements in microprocessor performance and power. In the new era of device scaling, innovations in materials and device structure are just as important as dimensional scaling. The past trend of using smaller transistors to build larger microprocessor cores operating at higher frequency and consuming more power is also at an end. The new era of microprocessor scaling is a system-on-a-chip approach that combines a diverse set of components using adaptive circuits, integrated sensors, sophisticated power-management techniques, and increased parallelism to build products that are many-core, multi-core, and multi-function. Although many promising technologies and device options are in the research pipeline, we need to recognize that we are doing system integration, and the future challenge we face is learning how to integrate an ever wider range of heterogeneous elements.