gebhart/patrepeval huggingface dataset:
Efficient Decentralized Economic Dispatch for Microgrids with Wind Power Integration (2014)

Decentralized energy management is of paramount importance in smart microgrids with renewables for various reasons including environmental friendliness, reduced communication overhead, and resilience to failures. In this context, the present work deals with distributed economic dispatch and demand response initiatives for grid-connected microgrids with high-penetration of wind power. To cope with the challenge of the wind's intrinsically stochastic availability, a novel energy planning approach involving the actual wind energy as well as the energy traded with the main grid, is introduced. A stochastic optimization problem is formulated to minimize the microgrid net cost, which includes conventional generation cost as well as the expected transaction cost incurred by wind uncertainty. To bypass the prohibitively high-dimensional integration involved, an efficient sample average approximation method is utilized to obtain a solver with guaranteed convergence. Leveraging the special infrastructure of the microgrid, a decentralized algorithm is further developed via the alternating direction method of multipliers. Case studies are tested to corroborate the merits of the novel approaches.
Alkenilezett kromonszármazékok szintézise Heck-reakcióval (2011)

A fémorganikus kémia elmúlt években tapasztalható rohamos mértékű fejlődése számos olyan reakció felfedezéséhez vezetett, amelyek azóta a szintetikus szerves kémia területén széleskörű alkalmazást nyertek. Ezek közül is az egyik legjelentősebb a keresztkapcsolási (az angol irodalomban használatos nevén „cross-coupling”) reakció, amely egy nagyon hatékony, átmenetifém katalizált, szén-szén kötés kialakítására alkalmas eljárás. A módszer fontosságát az is mutatja, hogy a 2010-es évben Richard F. Heck, Akira Suzuki és Ei-Ichi Negishi a róla elnevezett reakciókért (Heck-reakció, Suzuki-reakció, Negishi-reakció) kémiai Nobel-díjat kaptak. A nitrogéntartalmú heterociklusok körében a reakció igen elterjedt, de az oxigéntartalmú származékok, különösen a kromonoidok, flavonoidok, illetve kumarinok körében megjelent közlemények száma csekély. Ez arra ösztönzött, hogy szisztematikusan tanulmányozzuk a Heck-reakció alkalmazhatóságát ezen származékok körében. A keresztkapcsolási reakciók lehetőséget adhatnak számos, természetes forrásban megtalálható kromon és flavonszármazék előállítására. Kutatásaink során 3-helyzetben, illetve A-gyűrűben alkenilcsoporttal szubsztituált kromonok előállítását és a Heck-reakciót vizsgáltuk. A megfelelő körülmények birtokában a reakciót kiterjesztettük szomszédos helyzetben egy, illetve két hidroxilcsoportot tartalmazó kromonszármazékokra is és ezáltal megnyitottuk az utat a természetben előforduló származékok szintéziséhez.&#13;\n&#13;\nThe quick growth of the organometallic chemistry in the last years led to the discovery of several new synthetic methods which are widely used in the field of organic chemistry since then. One of the most important methodologies is the so-called „cross-coupling” reaction which is an efficient tool to build carbon-carbon bond in the presence of transition metals as catalysts. The importance of this methodology is clearly shown by the fact that Richard F. Heck, Akira Suzuki and Ei-Ichi Negishi received Nobel Prize in Chemistry in 2010 for such reactions which are carrying their name nowadays (Heck reaction, Suzuki reaction, Negishi reaction). The Heck reaction is widely applied in the field of nitrogen-containing heterocycles but the reports on its application for the synthesis of O-heterocycles, particularly chromonoids, flavonoids and coumarines are quite rare and sporadic. This prompted us to investigate systematically the usefulness of this method in the field of these benzopyran derivatives. These cross-coupling reactions would allow the synthesis of numerous naturally occurring chromones and flavones. In our research work we examined the synthesis of chromones with alkenyl substituents in their position 3 or in their ring A and the optimization of the Heck reaction for these substrates. Having the proper conditions in our hands we extended the reaction for various chromones and flavones with one or two adjacent hydroxyl group and we have opened the way to the synthesis of naturally occurring compounds.
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis (2012)

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP/protein kinase A (PKA)-regulated chloride channel whose phosphorylation controls anion secretion across epithelial cell apical membranes. We examined the hypothesis that cAMP/PKA stimulation regulates CFTR biogenesis posttranslationally, based on predicted 14-3-3 binding motifs within CFTR and forskolin-induced CFTR expression. The 14-3-3β, γ, and ε isoforms were expressed in airway cells and interacted with CFTR in coimmunoprecipitation assays. Forskolin stimulation (15 min) increased 14-3-3β and ε binding to immature and mature CFTR (bands B and C), and 14-3-3 overexpression increased CFTR bands B and C and cell surface band C. In pulse-chase experiments, 14-3-3β increased the synthesis of immature CFTR, reduced its degradation rate, and increased conversion of immature to mature CFTR. Conversely, 14-3-3β knockdown decreased CFTR B and C bands (70 and 55%) and elicited parallel reductions in cell surface CFTR and forskolin-stimulated anion efflux. In vitro, 14-3-3β interacted with the CFTR regulatory region, and by nuclear magnetic resonance analysis, this interaction occurred at known PKA phosphorylated sites. In coimmunoprecipitation assays, forskolin stimulated the CFTR/14-3-3β interaction while reducing CFTR's interaction with coat protein complex 1 (COP1). Thus 14-3-3 binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR available for anion secretion.
Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor (2012)

The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor growth, invasion, and metastasis. PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 showed more than 1,000-fold selectivity for c-Met compared with more than 150 kinases, making it one of the most selective c-Met inhibitors described to date. PF-04217903 inhibited tumor cell proliferation, survival, migration/invasion in MET-amplified cell lines in vitro, and showed marked antitumor activity in tumor models harboring either MET gene amplification or a hepatocyte growth factor (HGF)/c-Met autocrine loop at well-tolerated dose levels in vivo. Antitumor efficacy of PF-04217903 was dose-dependent and showed a strong correlation with inhibition of c-Met phosphorylation, downstream signaling, and tumor cell proliferation/survival. In human xenograft models that express relatively high levels of c-Met, complete inhibition of c-Met activity by PF-04217903 only led to partial tumor growth inhibition (38%-46%) in vivo. The combination of PF-04217903 with Recepteur d'origine nantais (RON) short hairpin RNA (shRNA) knockdown in the HT29 model that also expresses activated RON kinase-induced tumor cell apoptosis and resulted in enhanced antitumor efficacy (77%) compared with either PF-04217903 (38%) or RON shRNA alone (56%). PF-04217903 also showed potent antiangiogenic properties in vitro and in vivo. Furthermore, PF-04217903 strongly induced phospho-PDGFRβ (platelet-derived growth factor receptor) levels in U87MG xenograft tumors, indicating a possible oncogene switching mechanism in tumor cell signaling as a potential resistance mechanism that might compromise tumor responses to c-Met inhibitors. Collectively, these results show the use of highly selective inhibition of c-Met and provide insight toward targeting tumors exhibiting different mechanisms of c-Met dysregulation.
The effects of Large Scale use of active accelerator pedal in urban areas (2002)

The long term- and large scale effects of the active accelerator pedal in 284 vehicles in Lund were evaluated with regard to speed, traffic safety, driver behaviour, travel time, emissions and acceptance. The results showed that compliance with the speed limits improved among test drivers both according to their own statements and the objective measurements. The reductions in average speeds, and in speed distribution, better car following behaviour, increased attention and better behaviour towards pedestrians indicate a great traffic-safety potential. Fuel consumption and emissions decreased significantly. Travel times were unaffected. The majority of the interviewed test drivers think that there is a need for speed control measures and society must undertake such measures. The test drivers think that the active accelerator pedal is an efficient means to improve traffic safety and experience it as a support in car driving. However, those who need it most are the most negatively inclined to the idea. 1.
HIGH FREQUENCY ELECTRICAL CHARACTERIZATION OF 3D SIGNAL/GROUND THROUGH SILICON VIAS (2014)

D integration using through-silicon-vias (TSVs) is gaining considerable attention due to its superior packaging e-ciency resulting in higher functionality, improved performance and a reduction in power consumption. In order to implement 3D chip designs with TSV technology, robust TSV electrical models are required. Speciflcally, due to the increase of signal speeds into the gigahertz (GHz) spectrum, a high frequency electrical characterization best describes TSV behavior. In this letter, 5 £ 50m TSVs are manufactured using a via-mid integration scheme and characterized using S-parameters up to 65GHz. At 50GHz, the measured attenuation constant is 0.35dB/via with a time delay of 0.7ps/via.
Platelet aerobic metabolism: new perspectives (2019)

Although the role of platelets in hemostasis and thrombotic disorders as well as their contribution to inflammation are known, recent studies support the notion that much remains to be learned about platelet bioenergetics. Recent data suggest that platelets possess extra-mitochondrial oxidative phosphorylation (OXPHOS), which could represent one of sources of the chemical energy necessary for the prompt platelets activation. However, the extra-mitochondrial OXPHOS can play both beneficial and pathological roles, since the OXPHOS is the principal responsible of oxidative stress generation. For this reason, several authors evaluated the effects of polyphenols and other antioxidants on the modulation of the platelets oxidative stress production. In conclusion, we believe that a better understanding of platelet oxidative metabolism would allow a deeper knowledge of their physiology and the designing novel treatments targeting the role of platelets in many human diseases.
Preliminary X-ray analysis of XC5848, a hypothetical ORFan protein with an Sm-like motif fromXanthomonas campestris (2006)

XC5848, a hypothetical protein from the pathogenic bacterium Xanthomonas campestris that causes black rot, has been chosen as a potential target for the discovery of novel folds. It is unique to the Xanthomonas genus and has significant sequence identity mainly to corresponding proteins from the Xanthomonas genus. In this paper, the cloning, overexpression, purification and crystallization of the XC5848 protein are reported. The XC5848 crystals diffracted to a resolution of at least 1.68 A. They belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 48.13, b = 51.62, c = 82.32 A. Two molecules were found in each asymmetric unit. Preliminary structural studies nevertheless indicate that XC5848 belongs to the highly conserved Sm-like alpha-beta-beta-beta-beta fold. However, significant differences in sequence and structure were observed. It therefore represents a novel variant of the crucial Sm-like motif that is heavily involved in mRNA splicing and degradation.
The Museum as Contested Terrain: The Canadian Case (1997)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsJacqueline A. GibbonsJacqueline A. Gibbons writes about gender issues and has published a number of articles addressing the sociology of the arts. She teaches sociology and social science at York University in Toronto, Canada.
Negative Spin-Polarization ofSrRuO3 (2000)

We have made Meservey-Tedrow style spin-polarized tunneling measurements on SrRuO3, using a SrTiO3 barrier. In contrast to all other materials measured with this technique, we found the spin polarization to be negative, P = -9.5%. This makes it possible to test the generalized Julliere model for a negatively spin-polarized electrode, by measuring the magnetoresistance of a La(0.7)Sr(0. 3)MnO(3)/SrTiO(3)/SrRuO(3) tunnel junction. The generalized Julliere theory predicts it should be inverse.
Serotonin catabolism depends upon location of release: characterization of sulfated and γ‐glutamylated serotonin metabolites in Aplysia californica (2003)

The authors wish to make a correction to the above article that was published in J. Neurochem. 84, pp. 13581366 . The following sentence appeared in the Discussion section on pp. 1365 in the second paragraph. ‘However, in experiments in which crude 3 (∼ 20 µm) was incubated with individual or homogenized pedal and abdominal de-sheathed ganglia, 2 was observed, even with ample sulfate (26 mm) available in the incubation medium for formation of the cofactor PAPS.’ The correct sentence should read as follows. ‘However, in experiments in which crude 3 (∼ 20 µm) was incubated with individual or homogenized pedal and abdominal de-sheathed ganglia, 2 was not observed, even with ample sulfate (26 mm) available in the incubation medium for formation of the cofactor PAPS.’
FTIR Study of Hydrogen and Carbon Monoxide Adsorption on Pt/TiO2, Pt/ZrO2, and Pt/Al2O3 (1999)

The Pt/TiO2, Pt/ZrO2, and Pt/Al2O3 catalysts submitted to low-temperature reduction (LTR, 200 °C) and high-temperature reduction (HTR, 500 °C) and exposed to hydrogen and carbon monoxide at room temperature were studied by infrared spectroscopy. There is a strong loss of transmission in the entire infrared spectra on Pt/TiO2 after its exposure to hydrogen, which is related to the reducibility of the support. A typical SMSI behavior (strong metal−support interaction), such as the decrease in carbon monoxide adsorption capacity, was detected on Pt/TiO2 and Pt/ZrO2 after exposure to hydrogen, even for the catalysts submitted to LTR treatment. Also a carbonyl band shift to lower wavenumber was observed on LTR-treated Pt/TiO2, Pt/ZrO2, and Pt/Al2O3 after exposure to hydrogen. We interpreted this SMSI behavior as an electronic rather than morphological effect, which was induced by the presence of hydrogen spillover.
Cell-type deconvolution from DNA methylation: a review of recent applications (2017)

Recent advances in cell-type deconvolution approaches are adding to our understanding of the biology underlying disease development and progression. DNA methylation (DNAm) can be used as a biomarker of cell types, and through deconvolution approaches, to infer underlying cell type proportions. Cell-type deconvolution algorithms have two main categories: reference-based and reference-free. Reference-based algorithms are supervised methods that determine the underlying composition of cell types within a sample by leveraging differentially methylated regions (DMRs) specific to cell type, identified from DNAm measures of purified cell populations. Reference-free algorithms are unsupervised methods for use when cell-type specific DMRs are not available, allowing scientists to estimate putative cellular proportions or control for potential confounding from cell type. Reference-based deconvolution is typically applied to blood samples and has potentiated our understanding of the relation between immune profiles and disease by allowing estimation of immune cell proportions from archival DNA. Bioinformatic analyses using DNAm to infer immune cell proportions, part of a new field known as Immunomethylomics, provides a new direction for consideration in epigenome wide association studies (EWAS).
Optical signal processing using semiconductor optical amplifiers and applications to packet and burst switching (2003)

In this talk we review functions for optical packet and burst switching networks and the all-optical signal processing technologies that can be used to implement these functions. Research utilizing ultra-fast all-optical nonlinear fiber wavelength converters and InP integrated optical wavelength converters will be discussed as well as application to all-optical label swapping and WDM/OTDM networks.
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells (2007)

Long-chain saturated and monounsaturated fatty acids differ in their propensity to induce beta-cell death in vitro with palmitate (C16:0) being cytotoxic, whereas palmitoleate (C16:1n-7) is cytoprotective. We now show that this cytoprotective capacity extends to a poorly metabolised C16:1n-7 derivative, methyl-palmitoleate (0.25 mM palmitate alone: 92 +/- 4% death after 18 h; palmitate plus 0.25 mM methyl-palmitoleate: 12 +/- 2%; P < 0.001). Palmitoleate and its methylated derivative also acted as mitogens in cultured beta-cells (5-bromo-2-deoxyuridine incorporation - control: 0.15 +/- 0.01 units; 0.25 mM palmitoleate: 0.22 +/- 0.01 units; P < 0.05). It has been proposed that alterations in neutral lipid synthesis (particularly triacylglycerol (TAG) formation) might mediate the differential responses to saturated and unsaturated fatty acids and we have examined this proposition. Palmitate and palmitoleate both promoted beta-cell phospholipid remodelling and increased TAG formation (control: 0.9 +/- 0.1 nmol TAG/10(6) cells; 0.25 mM palmitate: 1.55 +/- 0.07; 0.25 mM palmitoleate: 1.4 +/- 0.05; palmitate plus palmitoleate: 2.3 +/- 0.1). By contrast, methyl-palmitoleate failed to influence TAG levels (0.25 mM methyl-palmitoleate alone: 0.95 +/- 0.06 nmol TAG/10(6) cells; methyl-palmitoleate plus palmitate: 1.5 +/- 0.05) or its fatty acid composition in beta-cells exposed to palmitate. The results suggest that monounsaturated fatty acids can promote cell viability and mitogenesis by a mechanism that does not require their metabolism and is independent of alterations in TAG formation.
Improvement of Renal Function with Selective Thromboxane Antagonism in Lupus Nephritis (1989)

To test the hypothesis that the vasoconstrictor thromboxane A2 may affect renal hemodynamics in lupus nephritis, we examined the short-term effects of a selective thromboxane-receptor antagonist, BM 13,177, and of low-dose aspirin. In a randomized, double-blind, crossover study, 10 patients with biopsy-proved lupus nephritis were given a 48-hour continuous infusion of BM 13,177 or placebo. At base line, seven patients had markedly elevated urinary levels of thromboxane B2, the breakdown product of thromboxane A2. During the infusion of BM 13,177, the inulin clearance rate, which was 68 ml per minute per 1.73 m2 of body-surface area at base line, increased by an average of 24 percent (range, 12 to 47 percent; P less than 0.01). Para-aminohippurate clearance was increased to the same extent, with no change in the filtration fraction. The bleeding time doubled, indicating an occupancy of platelet thromboxane receptors of more than 95 percent. The hemodynamic changes were associated with a significant increase in sodium excretion from 76 to 118 mmol per day (P less than 0.01) but with no change in arterial blood pressure. In another study, 10 additional patients with lupus nephritis were randomly assigned to receive either placebo or 20 mg of aspirin twice daily for four weeks. The aspirin regimen produced a selective, cumulative inhibition of platelet cyclooxygenase activity and a doubling of bleeding time. However, there was no change in the inulin clearance rate and no change in urinary levels of thromboxane B2 or 6-keto-prostaglandin F1 alpha, which are indicators of renal synthesis of thromboxane A2 and prostacyclin, respectively. We conclude that in lupus nephritis, impairment of renal function is at least in part mediated hemodynamically and is reversible with a thromboxane antagonist. Platelets, however, are not a major source of thromboxane A2 synthesis and action within the kidney.
Correlation of C-Reactive Protein with Survival and Radiographic Response to First-Line Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer (2008)

Measurement of CRP before initiation and during a platinum-based chemotherapy can provide prognostic information for the individual patient with advanced NSCLC and is able to support or even replace assessment of response by radiographic imaging in defined situations.
Head Impact Exposure and Mechanisms in Female High School Lacrosse via an Instrumented Mouthguard (2021)

<h3>Objective</h3> To quantify the head impact biomechanics, by impact mechanism, of female high school lacrosse players during games using an instrumented mouthguard. <h3>Background</h3> There is growing concern for the neurologic effects of repetitive head impacts in sports, which have been linked with several short-term neurophysiologic deficits. Girls9 lacrosse represents a popular but understudied sport with regard to head impact exposure and current debate exists as to the need for enhanced protective equipment. <h3>Design/Methods</h3> A female high school varsity lacrosse team wore the Stanford Instrumented Mouthguard during competitive games for the 2019 season. Video footage was reviewed to confirm head impact events and remove false-positive recordings. For each impact event, the mechanism was coded as stick contact, player contact, fall, or ball contact. Head impact rates were calculated per athlete exposure (AE, defined as a single player participating in a single game). <h3>Results</h3> Sensor data were recorded for 15 female varsity lacrosse players for 14 games and 97 AEs. During games, 31 sensor-recorded head impacts were video-confirmed resulting in a pooled average head impact rate of 0.32 impacts/AE. The video-confirmed impacts were distributed between stick contact (17, 54.8%), player contact (12, 38.7%), and falls (2, 6.5%). There were no ball impacts. Overall peak kinematics were 34.0 ± 26.6 g, 12.0 ± 9.1 rad/s, and 3,666.5 ± 2,987.6 rad/s2. Stick contacts had the highest peak linear acceleration (42.7 ± 32.2 g), angular velocity (14.5 ± 11.1 rad/s), and angular acceleration (4,242.4 ± 3,634.9 rad/s2). <h3>Conclusions</h3> Stick impacts were the most common impact mechanism and resulted in the highest peak linear and angular kinematics, which may help explain why they are the most common cause of head injury in female lacrosse. By quantifying the head impact exposure, kinematics and mechanisms in female high school lacrosse, targeted injury preventions can be developed, such as rule changes and protective equipment.
Dynamic Frame-Slotted Aloha in RFID Using Received Signal Strength Information (2020)

Received signal strength information based dynamic frame-slotted Aloha (RSSI-DFSA) RFID is proposed to replace random slot access where idle and collided slots lead to low system efficiency. Tag coordinates are calculated from received signal strength information, and the slot is chosen based on the coordinates. Simulations show that RSSI-DFSA system efficiencies are 14.9%, 2.4%, and 2.1% higher, and the time efficiencies are 8.3%, 2.5%, and 1.8% higher than those of existing algorithms, when the path loss exponent is 4 and the standard deviations of the shadowing are 1, 2, and 3 dB.