gebhart/patrepeval huggingface dataset:
CXCL12 Mediates CCR7-independent Homing of Central Memory Cells, But Not Naive T Cells, in Peripheral Lymph Nodes (2004)

Central memory CD8(+) T cells (T(CM)) confer superior protective immunity against infections compared with other T cell subsets. T(CM) recirculate mainly through secondary lymphoid organs, including peripheral lymph nodes (PLNs). Here, we report that T(CM), unlike naive T cells, can home to PLNs in both a CCR7-dependent and -independent manner. Homing experiments in paucity of lymph node T cells (plt/plt) mice, which do not express CCR7 ligands in secondary lymphoid organs, revealed that T(CM) migrate to PLNs at approximately 20% of wild-type (WT) levels, whereas homing of naive T cells was reduced by 95%. Accordingly, a large fraction of endogenous CD8(+) T cells in plt/plt PLNs displayed a T(CM) phenotype. Intravital microscopy of plt/plt subiliac lymph nodes showed that T(CM) rolled and firmly adhered (sticking) in high endothelial venules (HEVs), whereas naive T cells were incapable of sticking. Sticking of T(CM) in plt/plt HEVs was pertussis toxin sensitive and was blocked by anti-CXCL12 (SDF-1alpha). Anti-CXCL12 also reduced homing of T(CM) to PLNs in WT animals by 20%, indicating a nonredundant role for this chemokine in the presence of physiologic CCR7 agonists. Together, these data distinguish naive T cells from T(CM), whereby only the latter display greater migratory flexibility by virtue of their increased responsiveness to both CCR7 ligands and CXCL12 during homing to PLN.
Improved current distribution in resistive memory on flexible substrate using nitrogen-rich TaN electrode (2012)

Narrow current distribution, good endurance, and low 28 μW switching power are successfully achieved in Ni/GeOx/TiOy/TaN resistive random access memory devices. The good distribution and endurance are attributed to the nitrogen-rich TaN to increase the oxidation resistance and decrease the TaON and oxygen vacancies formation from x-ray photoelectron spectroscopy measurements, where such oxygen vacancies are related to current conduction at high resistance state. In addition, the devices on the flexible polyimide substrate exhibit excellent mechanical endurance upon repeated bending tests, showing their high potential for low-cost flexible memory application.
Calibration issues with Shack-Hartmann sensors for metrology applications (2004)

A long-standing goal of optical metrology is testing aspherics without the need for part specific nulls lenses. The problem involves increasing the measurement dynamic range while preserving accuracy. The Shack-Hartmann wavefront sensor offers an interesting alternative to interferometry where the dynamic range is tied to the wavelength of light. Because the Shack-Hartmann wavefront sensor is a geometric test, the lenslet array can be designed in a way that trades sensitivity for dynamic range making it possible to test, without a null, aspheres that would otherwise require null optics. However, a system with this much dynamic range will have special calibration issues. Shack-Hartmann wavefront sensors are widely used in feedback control systems for adaptive optics. In that application, calibration is not a serious problem as the system drives the correction to a null; calibration errors slow the rate of convergence. For metrology applications, the calibration of the Shack-Hartmann wavefront sensor must be absolute. This presentation will discuss issues related to the design and calibration of a Shack-Hartmann metrology system including the design of an appropriate lenslet array, methods for dealing with induced aberrations, vignetting and spatial resolution limitations.
New boiler tube material HCM9M (1982)

A high strength tube material HCM 9M (Low C-9 Cr-2 Mo), which has an intermediate high temperature strength between commercial austentitic steels and low alloy steels, has been developed jointly by Mitsubishi Heavy Industries, Ltd. and Sumitomo Metal Industries, Ltd. HCM 9M has various superior characteristics: higher oxidation resistance and higher temperature strength than T22 (2/14 Cr-1 Mo steel); good bending property and weldability; and freedom from stress corrosion cracking. HCM 9M has been trially used in 7 plants for over 7 years as reheater and superheater tubes. The results of metallurgical investigation after 6 years' service indicate that it shows normal deterioration with superior resistance to steam-induced oxidation and high temperature corrosion.
Controlling Eu2+ Substitution towards a Narrow-Band Green-Emitting Borate Phosphor NaBaB9O15:Eu2+ (2019)

Highly efficient, thermally stable, narrow-band phosphors that can be excited by a blue LED chip are crucial for energy-efficient light bulbs and display lighting. Here, a rare narrow-band, green-emitting phosphor based on the compound NaBaB9O15:Eu2+ is demonstrated. The emission peak is centered at 515 nm with a full-width at half-maximum (fwhm) of 61 nm (2294 cm−1), and a photoluminescence quantum yield of >80% using blue or near-UV LED excitation. This borate’s remarkable green emission stems from Eu2+ substituting on the smaller [NaO6] polyhedron instead of the larger and more favorable [BaO9] polyhedron. The phosphor also exhibits negligible thermal quenching up to 650 K owing to the wide band gap, high connectivity of the rigid NaBaB9O15 crystal structure, and the depopulation of trap-states. This combination of optical properties and its straightforward synthesis conditions makes NaBaB9O15:Eu2+ an ideal green phosphor for next-generation LED-based lighting or display systems.
Effect of Silicon Carbide on the Mechanical and Thermal Properties of Snake Grass/Sisal Fiber Reinforced Hybrid Epoxy Composites (2021)

In this study, an attempt was made to develop and characterize Snake Grass Fiber (SGF)/Silicon Carbide (SiC)/epoxy and Snake Grass Fiber/Sisal Fiber (SF)/Silicon Carbide/epoxy hybrid composites using a compression moulding technique. Mechanical characteristics of the produced hybrid composites such as tensile, flexural, and hardness tests were analyzed. Also experiments have been carried out to predict the thermal stability of the fabricated composite samples. The interface between fiber and matrix was examined by using Scanning Electron Microscopy (SEM). Among SGF/SiC/epoxy and SGF/SF/SiC/epoxy composites, it has been observed that hybrid composite SGF/SF/SiC/epoxy exhibits the higher hardness of 82 Shore-D, tensile strength of 51 MPa and flexural strength of 73 MPa. In contrast to the mechanical properties, the percentage of water absorption was lower in the SGF/SiC/epoxy hybrid composite. It is proven from the results that the SGF/SF/SiC/epoxy hybrid composites will enhance the strength of the composites. This composite material is also a potential candidate for the hardware of energy devices including electrochemical energy along with Fuel Cell systems.
Quantitative Determination of Phenolic Compounds in Lotus (Nelumbo nucifera) Leaves by Capillary Zone Electrophoresis (2012)

The traditional use of lotus leaves as an anti-inflammatory remedy is associated with the occurrence of phenolic compounds. In this study the first CE method for the analysis of all major phenolic constituents in Nelumbo nucifera leaves is presented. It permits the separation of nine relevant markers in less than 10 min. The optimized procedure was fully validated and then used to analyze diverse samples collected in Vietnam. They revealed significant qualitative and quantitative differences depending on growing area and season. Yet, in all of them, quercetin-3-O-β-D-glucuronide, hyperoside, and isoquercitrin were the most dominant flavonoids.
Design Methodology and Optimization of Distributed MEMS Matching Networks for Low-Microwave-Frequency Applications (2009)

A design methodology for the distributed microelectromechanical system (MEMS) impedance matching networks based on the optimization of the uniformity of the Smith chart coverage has been developed. The proposed approach was validated through a comparison between a traditional coplanar waveguide (CPW) design and an improved design based on a slow-wave (SW) structure. The enhanced reconfigurable impedance matching network has been developed for low-frequency applications. The network is based on a distributed MEMS transmission line (DMTL) coupled with the SW structure to reduce the total physical length of the network by 25% in comparison with a traditional DMTL. An extensive analysis was performed to identify the impact of each design parameter in order to optimize the structure and reduce the required size for relatively low-frequency applications. Several parameters are extracted from the electromagnetic simulation results and are used to design the proposed impedance matching network. Measurement results confirm the efficiency of the proposed design methodology in improving the impedance coverage and also miniaturization of the DMTL impedance matching networks.
More About Covariance Descriptors for Image Set Coding: Log-Euclidean Framework based Kernel Matrix Representation (2019)

We consider a family of structural descriptors for visual data, namely covariance descriptors (CovDs) that lie on a non-linear symmetric positive definite (SPD) manifold, a special type of Riemannian manifolds. We propose an improved version of CovDs for image set coding by extending the traditional CovDs from Euclidean space to the SPD manifold. Specifically, the manifold of SPD matrices is a complete inner product space with the operations of logarithmic multiplication and scalar logarithmic multiplication defined in the Log-Euclidean framework. In this framework, we characterise covariance structure in terms of the arc-cosine kernel which satisfies Mercer's condition and propose the operation of mean centralization on SPD matrices. Furthermore, we combine arc-cosine kernels of different orders using mixing parameters learnt by kernel alignment in a supervised manner. Our proposed framework provides a lower-dimensional and more discriminative data representation for the task of image set classification. The experimental results demonstrate its superior performance, measured in terms of recognition accuracy, as compared with the state-of-the-art methods.
P289SPECT camera head configuration, acquisition time, and resolution recovery processing impact image defect size quantification (2019)

Background: Defect size quantification in single photon emission computerized tomography (SPECT) myocardial perfusion images is an important aspect of clinical risk stratification, although the effects of various acquisition and processing variables are not well established.
A Methodology to Automate the Selection of Design Patterns (2016)

Background: Over the last two decades, numerous software design patterns have been introduced and cataloged on the basis of developer's interest and skills. Motivation: In software design phase, inexperienced designers are mostly concerned on how to select an appropriate design pattern from the catalog of relevant patterns in order to solve a design problem. The existing automated design pattern selection methodologies are limited to the need of formal specification of design patterns or an appropriate sample size to make the learning process more effective. Method: To address this concern, we propose a three step methodology to automate the selection process of design pattern for a design problem. The steps of the methodology are text preprocessing, use of an unsupervised learning technique (that is Fuzzy c-Mean) as a core function to quantitatively determine the resemblance of different objects and selection of most appropriate pattern for a design problem. We evaluate our methodology with two samples that is Gang-of-Four (GoF) design pattern and spoiled pattern collection, and three object-oriented related design problems. Moreover, we used Fuzzy Silhouette test, Kappa (k) test, Cosine Similarity and argmax function to measure the effectiveness of our methodology. Results: In case of GoF pattern collection, we validated the reliability of Fuzzy c-Mean (FCM) results using a classification decision tree, and observed promising results compared to other automation techniques. Conclusion: From the comparison results, we observed 11%, 4% and 18% improvement in the performance of proposed technique as compared to supervised learning techniques of Support Vector Machine, Naïve Bayes and C4.5 respectively.
Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models (2019)

Duchenne muscular dystrophy is a severe pediatric neuromuscular disorder caused by the lack of dystrophin. Identification of biomarkers is needed to support and accelerate drug development. Alterations of metabolites levels in muscle and plasma have been reported in pre-clinical and clinical cross-sectional comparisons. We present here a 7-month longitudinal study comparing plasma metabolomic data in wild-type and mdx mice. A mass spectrometry approach was used to study metabolites in up to five time points per mouse at 6, 12, 18, 24 and 30 weeks of age, providing an unprecedented in depth view of disease trajectories. A total of 106 metabolites were studied. We report a signature of 31 metabolites able to discriminate between healthy and disease at various stages of the disease, covering the acute phase of muscle degeneration and regeneration up to the deteriorating phase. We show how metabolites related to energy production and chachexia (e.g. glutamine) are affected in mdx mice plasma over time. We further show how the signature is connected to molecular targets of nutraceuticals and pharmaceutical compounds currently in development as well as to the nitric oxide synthase pathway (e.g. arginine and citrulline). Finally, we evaluate the signature in a second longitudinal study in three independent mouse models carrying 0, 1 or 2 functional copies of the dystrophin paralog utrophin. In conclusion, we report an in-depth metabolomic signature covering previously identified associations and new associations, which enables drug developers to peripherally assess the effect of drugs on the metabolic status of dystrophic mice.
Diastereoselective Synthesis of Cyclic sp3-Enriched cis-β-Alkoxysulfonyl Chlorides (2018)

A three-step synthesis of β-alkoxy-substituted alicyclic sulfonyl chlorides from cyclic alkenes and alcohols is reported. The scope of the method was studied for a range of the substrates with various steric and electronic properties. The title compounds were obtained on a hundred-gram scale in up to 52% overall yield scale as single cis-diastereomers.
Global Optimization Algorithms and their Application to Distributed Systems (2008)

In this report, we discuss the application of global optimization and Evolutionary Computation to distributed systems.We therefore selected and classified many publications, giving an insight into the wide variety of optimization problems which arise in distributed systems.Some interesting approaches from different areas will be discussed in greater detail with the use of illustrative examples.
Supplementary Table 2 from ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells (2023)

&lt;p&gt;YW3-56 microarray data&lt;/p&gt;
The life history of Libythea geoffroy nicevillei Olliff (Lepidoptera: Libytheidae) (1989)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Narrative film-making (1976)

Teachers often write to METRO asking us to print a detailed Film Studies syllabus. Until now, we haven't had the resources to complete such a project. But this year, Barbara Boyd, film studies teacher at Brunswick East High School, has been working on a FILM KIT, which would contain such a detailed course. METRO and the Joint Committee will publish Barbara's kit next year. But in the meantime we have printed her introduction and an early section of the kit. If you have any ideas about the contents and presentation of this material, please contact Barbara at school or through the Joint Committee.
Osteopontin is expressed and functional in human eosinophils (2009)

We therefore conclude that OPN is likely to contribute to the process of angiogenesis observed in the airways in asthma.
Altered muscular activation patterns and force feedback after spinal cord injury (2012)

One of the major clinical problems associated with spinal cord injury (SCI) is the lack of animal's ability to maintain weight support during standing or walking. We hypothesize that following SCI there is reorganization of the postural limb reflexes driven by stretch and load receptors in addition to loss of excitatory inputs from supraspinal structures to spinal interneurons that could result in altered intermuscular interactions. In control decerebrate animals there is a proximal to distal gradient in the strength of inhibitory force feedback among the limb muscles. We propose that pathways mediating this inhibition may remain inhibitory after spinal hemisection but their strengths may change to a distal to proximal gradient in the animal resulting in a loss of weight support. We also propose that ventral horn pathways are important for regulating the distribution of intermuscular force feedback. To test our hypothesis we are studying two types of SCI, namely dorsal and lateral hemisections, at both acute and chronic time points post‐injury. We measured intermuscular force feedback using combinations of stretches applied to pairs of muscles. Our most recent evidence supports our hypothesis and shows that the intermuscular force feedback is reversed after lateral but not dorsal hemisections. This work is supported by NIH grant HD32571, 1 I01 RX000243‐01A1, State of Florida BSCIRTF
Treatment of Functional Mitral Regurgitation by Percutaneous Annuloplasty: Results of the TITAN Trial (2012)

Percutaneous reduction of FMR using a coronary sinus approach is associated with reverse LV remodelling. Significant clinical improvements persisted up to 24 months.
Composite Fuselage Impact Testing and Simulation: A Model Calibration Exercise (2014)

Results from a model calibration study of a composite fuselage front frame test article subjected to impact loading are presented. The effort, undertaken over a 2 year time period, involved both modal and impact testing of the front frame section of a composite fuselage test article. Data from both types of tests were used with multi-dimensional calibration metrics to assess model adequacy. Specifically, two metrics are used: (1) a metric to assess the probability of enveloping the measured displacement during impact, and (2) an orthogonality metric to assess model adequacy between test and analysis. Because the impact test is destructive, vibration test data were also collected for model assessments in terms of modes of vibration. To justify the use of vibration data for calibration of the impact model, the paper discusses how to assess the relevancy of vibration data for calibration of impact models. Finally, results from the impact test are discussed and compared to model predictions and model uncertainty bounds.
Post-CMOS and Post-MEMS Compatible Flexible Skin Technologies: A Review (2013)

This paper reviews flexible skin technologies that enable monolithic integration of silicon CMOS circuits and high temperature MEMS devices on flexible substrates. The monolithic integration is achieved by fabricating CMOS circuits or MEMS sensors on silicon wafers first and then forming flexible skins by post-processing. In this sense, these flexible skin technologies are termed as post-CMOS and -MEMS compatible. Most flexible devices developed using these technologies share a common structure - silicon islands connected by flexible cables. Representative works in this field are reviewed. Important aspects such as materials, releasing methods, and interconnection methods are discussed. A brief comparison of post-CMOS and -MEMS compatible flexible skin technologies with other technologies is presented.
Characterization of microbial functional and genetic diversity as a novel strategy of biowaste ecotoxicological evaluation (2018)

The goal was to elucidate the importance of the waste properties for effective exploitation in biogas production and for soil application, respectively, based on the physicochemical and microbial characterization of biowaste and the corresponding biogas residues. The following waste media were chosen: fruit waste, dairy sewage sludge, corn silage, grass silage, and grain brew to prepare three co-substrates for anaerobic bioconversion. The most satisfactory biogas yield was obtained from biowaste with the following composition: 25% fruit wastes, 25% dairy sewage sludge, 12% corn silage, and 38% grain brew. The study included functional and genetic diversity assessment through the characterization of the catabolic potential and structure of the microbial communities inhabiting the examined organic wastes and their relative biogas residues. The metabolome was based on the use of a Biolog® plate. The elucidation of the metagenome employed the genetic structure of prokaryotes and involved denaturing gradient gel electrophoresis and next-generation sequencing analyses. The usefulness of metagenomics was emphasized by ecotoxicological evaluation of biowaste and in determining the accurate start-up community composition for biogas production, highlighting the pivotal role of anammox and hydrolytic bacteria as marker groups. The high importance of the great diversity of fungi was also revealed based on a functional approach.
Influence of a dust storm on carbon monoxide and water vapor over the Indo‐Gangetic Plains (2007)

Dust storms are meteorological phenomena that produce air quality hazards over specific regions lasting from a few hours to many days. They are common in the western part of India during the months of April–June, particularly over Delhi and the surrounding Indo‐Gangetic (IG) plains. In this paper, a dust storm event over Delhi, Kanpur and Varanasi during 1–11 April 2005 was used to study the vertical changes in the atmosphere. We studied data from the Measurement of Pollution in the Atmosphere (MOPITT) instrument onboard the Terra satellite, daytime vertical carbon monoxide (CO) mixing ratio and the Atmospheric Infra‐red Sounder (AIRS) onboard the Aqua satellite water vapor mass mixing ratio associated with dust storm over three locations in the IG plains. Evidence of vertical transport of CO to upper troposphere (UT) is observed from stability indices derived from radiosonde data, NCEP reanalysis wind and HYSPLIT model over Delhi. The strong upward convection during dust storms reduces CO in the lower troposphere and increases CO at around 350 hPa pressure level. Water vapor mass mixing ratio shows an increase at 700–850 hPa pressure level during the dust storm event over all locations. The changes of water vapor mass mixing ratio and CO during the dust storm are found to be more pronounced over Delhi and Kanpur while they are comparatively less over Varanasi, due to low intensity during transport of dust from west to east in the IG plains. The increased concentration of CO and water vapor mass mixing ratio at different pressure levels 350 hPa and 700–850 hPa respectively with corresponding decrease in surface concentration (at pressure level 700–1000 hPa and 925–1000 hPa respectively) have been investigated during a major dust storm period. The changes in CO and water vapor mass mixing ratio are found to be consistent with the observed changes in vertical stability of the atmosphere.