gebhart/patrepeval huggingface dataset:
Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease (1993)

Neurologic and psychologic tests without brain tissue biopsy do not establish the diagnosis of Alzheimer's disease. This pilot study demonstrates significant increases in the activity of plasma glutamate dehydrogenase and the plasma concentrations of aspartate, glutamate, and alpha-ketoglutarate in nursing home residents with previously diagnosed Alzheimer's disease when compared with that in other nursing home residents without Alzheimer's disease who had no complicating conditions. Plasma concentrations of gamma-aminobutyric acid, glutamine, and activities of plasma glutamate decarboxylase, glutaminase, and glutamine synthetase were not significantly different in the two groups. A discriminant analysis number, based on the four significantly different compounds, is obtained that may be used as the basis for an inexpensive, non-invasive, and accurate screening test for Alzheimer's disease.
[Electrophysiological evaluation of effectiveness of enteral nutritional therapy at bowel diseases]. (2009)

The enteral nutritional therapy for patients with Crohn disease in postoperative period, as well as with left-sided colon resection and right colon resection was assessed. The electromotor activity of the colon was examined before and after the Klinipit and the Mucofalk administration. The colon alterations correspond the intestinal failure clinical symptoms. This has been confirmed that the method of electromyography may be recommended for the noninvasive assessment of enteral nutrition therapy of patients with colon hemicolectomy.
Size-controlled synthesis of cyclodextrin-capped gold nanoparticles for molecular recognition using surface-enhanced Raman scattering (2021)

Cyclodextrin (CD)-capped gold nanoparticles (AuNPs) can be applied in sensing, catalysis, and self-assembly processes due to their molecular recognition ability. As the plasmon resonance of AuNPs depends on their size, the size-controlled synthesis of CD-capped AuNPs is essential for the development of these applications. Herein, we successfully synthesized β-CD-capped AuNPs with diameters of 24-85 nm using a seed-mediated growth method. The AuNPs were prepared using a β-CD as both the reducing agent and the capping agent. Harsh reagents such as NaBH<sub>4</sub> and NaOH were not used. The size-controlled synthesis of β-CD-capped AuNPs was achieved by changing the amount of seed solution. We fabricated monolayers of β-CD-capped AuNPs by liquid-liquid interfacial self-assembly for application in surface-enhanced Raman scattering (SERS). The SERS intensity is significantly improved by using larger β-CD-capped AuNPs. In addition, we found that β-CDs can detect pyrene with higher sensitivity than α-CDs on the basis of the difference in molecular recognition ability between α-CDs and β-CDs.
Automatic differential segmentation of the prostate in 3-D MRI using Random Forest classification and graph-cuts optimization (2012)

In this paper we address the problem of automated differential segmentation of the prostate in three dimensional (3-D) magnetic resonance images (MRI) of patients with benign prostatic hyperplasia (BPH). We suggest a framework that consists of two stages: in the first stage, a Random Forest classifier localizes the anatomy of interest. In the second stage, Graph-Cuts (GC) optimization is utilized for obtaining the final delineation. GC optimization regularizes the hypotheses produced by the classification scheme by imposing contextual constraints via a Markov Random Field model. Our method obtains comparable or better results in a fully automated fashion compared with a previous semi-automatic technique [6]. It also performs well, when small training sets are used. This is particularly useful in on-line interactive segmentation systems, where prior knowledge is limited, or in automated approaches that generate ground truth used for model-building.
Energietransfer-Prozesse (1999)

Neben den in Kapitel 2 ausführlich diskutierten monomolekularen Mechanismen tragen auch bimolekulare Prozesse wesentlich zur Desaktivierung eines Moleküls nach elektronischer Anregung bei. Prinzipiell lassen sich Energie- und Ladungstransfer unterscheiden. Bevor wir uns der Diskussion und Betrachtung einiger interessanter Beispiele aus der Photobiophysik zuwenden, sollen zunächst die theoretischen Grundlagen in komprimierter Form dargelegt werden.
Effect of surface treatment on electrical properties of GaN metal–insulator–semiconductor devices with Al 2 O 3 gate dielectric (2020)

Abstract This research proposes an economical and effective method of 1-octadecanethiol (ODT) treatment on GaN surfaces prior to Al 2 O 3 gate dielectric deposition. GaN-based metal–insulator–semiconductor (MIS) devices treated by HCl, O 2 plasma and ODT are demonstrated. ODT treatment was found to be capable of suppressing native oxide and also of passivating the GaN surface effectively; hence the interface quality of the device considerably improved. The interface trap density of Al 2 O 3 /GaN was calculated to be around 3.0 × 10 12 cm −2 eV −1 for devices with ODT treatment, which is a relatively low value for GaN-based MIS devices with Al 2 O 3 as the gate dielectric. Moreover, there was an improvement in the gate control characteristics of MIS-HEMTs fabricated with ODT treatment.
Temperature-independent pitch invariance in cholesteric liquid crystal (2014)

We report a pitch invariance in cholesteric liquid crystals (CLCs) independent of temperature by mixing two chiral dopants. One dopant tends to shorten the helical pitch of the CLC, but the other makes the pitch longer, with increasing temperatures. From an analysis of temperature dependencies of the pitch for each dopant, we determined the mixing ratio of two chiral dopants for the pitch invariance. Finally, we obtained the pitch-invariant CLCs to temperature and the helical twisting power of the mixed dopant was estimated.
Gestion clinique et réhabilitation du patient souffrant de schizophrénie et réfractaire au traitement : fondements conceptuels et résultats (première partie) (2005)

Despite advances in psychopharmacology for people with schizophrenia, many patients remain too disabled to be discharged from public psychiatric facilities. This paper describes the development of a public-private partnership which led to the creation of a specialized, intensive behavioral rehabilitation program for schizophrenia patients who were considered to be treatment-refractory at public hospitals. The essential elements of this treatment program are described, along with the philosophical bases of its treatment. Outcome data are discussed to emphasize the point that when evidence-based treatment is implemented with this population, outcomes can be positive in most cases, and therefore, the number of "treatment-refractory" patients is actually less than is estimated based on response to medication alone.
Green, Green Destiny (1988)

THOSE BAPTISTS will plop a church down anywhere. All those evan gels are just the same. Driving home today I saw where they converted the old drawbridge tollbooth, converted it right into a sinners do-drop in. I would not be the least bit surprised or astonished to see some small new meeting hall cropped up anywhere. They'll probably have one down to the frozen food department at the Krogers. The Krogers, nevermind you. I would not be astounded.
Etiopathogenetic Approach to Conservative Treatment of Pelvic Congestion Syndrome (2016)

Aim of research is clinical, laboratory and instrumental evaluation of efficiency of proposed pathogenetic conservative treatment for Pelvic Congestion Syndrome in women of reproductive age. Complex treatment consisted of oral use of diosmin, chondroitin sulfate for 6 months and physiotherapy. The results of the study suggest that proposed treatment is effective enough. It provides recovery of varicose veins endothelium functions, dynamic balance between vasodilatory and vasoconstrictor factors, normalization of blood rheology and metabolic processes in connective tissue. Key words: Pelvic Congestion Syndrome, conservative treatment, venotonic therapy.
Heterogeneity in the Prevalence of High-Risk Human Papillomavirus Infection in Human Immunodeficiency Virus-Negative and Human Immunodeficiency Virus-Positive Men Who Have Sex With Men in West Africa (2021)

HR-HPV prevalence was very heterogeneous between the study countries in both HIV-negative and HIV-positive MSM. Vaccine-preventable HPV infections predominated. Vaccination should be proposed to young MSM to reduce the burden of HPV infection in this vulnerable population and their female partners in West Africa.
Soft Core–Hard Shell Silicone Hybrid Nanoparticles Synthesized by Miniemulsion Polymerization: Effect of Silicone Content and Crosslinking on Latex Film Properties (2011)

Composite nanoparticles consisting of ‘soft’ silicone oil and ‘hard’ polyacrylate with core–shell morphology were obtained by a one-step synthesis via the miniemulsion process. Various parameters, i.e. the viscosity and amount of the silicone, the surfactant content, the (co)monomers affecting the particle size and morphology were studied. With an optimum hydrophilicity of the polymer shell, composite particles possessing a well-defined core–shell morphology were obtained as determined by transmission electron microscopy. The fully encapsulated silicone oil (40 wt-%) in a slightly crosslinked polyacrylate shell showed good film formation as revealed by atomic force microscopy. The ability to highly confine silicone oil in the composite film could clearly be evaluated from contact angle measurements. By finely changing the crosslink concentration in the polymeric shell, tunable hydrophobic properties of films cast from silicone core–polyacrylate shell latexes could be achieved. In addition, the high thermal resistance and excellent water-resistant properties of the film were shown by thermal gravimetric analysis and water swelling determination. These composite latexes are presented as new alternatives for practical utility in waterborne coatings.
Effect of halogen substituents on the gas-phase acidities and electron affinities of methylenes and methylidynes: calculation of heats of formation (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of halogen substituents on the gas-phase acidities and electron affinities of methylenes and methylidynes: calculation of heats of formationC. F. Rodriquez and A. C. HopkinsonCite this: J. Phys. Chem. 1993, 97, 4, 849–855Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100106a009https://doi.org/10.1021/j100106a009research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Heat‐shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis (2005)

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and ranks second in China. The prognosis of HCC remains dismal mainly because of its late diagnosis, especially in patients with coexisting chronic liver diseases. To identify serum biomarkers for HCC, sera from 20 healthy volunteers, 20 hepatitis B virus (HBV) infected patients and 20 HCC patients were selected for screening study and same number of sera into the same three groups were used for validation study. A strategy including sonication, albumin and immunoglobulin G (IgG) depletion and desalting was optimized for screening differentially expressed proteins of low abundance in serum. By 2-DE image analysis and MALDI-TOF-MS/MS identification, eight proteins including heat-shock protein 27 (HSP27), alpha-fetoprotein (AFP), alpha-1 antitrypsin, clusterin, caeruloplasmin, haptoglobin alpha2 chain, tranferrin and transthyretin were found significantly changed among the healthy, HBV and HCC groups. Further validation study by Western blot showed the detection of HSP27 in 90% HCC sera and two HBV sera, but in none of normal sera. Thus, 2-DE based serum proteome analysis can be useful in the screening of serum biomarkers for HCC and HSP27 could aid in the diagnosis of HCC though further validation is needed.
Quantum-confined field-effect light emitters: device physics and experiments (1990)

Extended experimental results on three-terminal quantum-confined field-effect light emitters with current injection and field control of luminescent characteristics in the quantum-well structure are reported. By incorporating superlattice buffer layers (SLBLs), the quantum efficiency of the device is dramatically improved and equivalently nonradiative recombination processes are sufficiently suppressed at room temperature. The red-shift of the emission spectra by the quantum-confined Stark effect assures that the electric field is effectively applied to the quantum well. The experimental data on the transient responses of emission intensity to input voltage pulses show fairly good correspondences with theoretical prediction and previous photoluminescence experiments. The authors discuss the ultimate capability of high-speed switching and point that an optical pulse with a duration as short as 30 ps and involving more than 100 photons can be generated by scaling down the size of the device with 1% external efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Stropharioideae (Strophariaceae, Agaricales) from Santa Maria, Rio Grande do Sul, Brazil (2004)

Volume: 89
Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity (2020)

Genetic activation of hedgehog/glioma-associated oncogene homolog (HH/GLI) signaling causes basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Using a genetic mouse model of BCC, we identified profound differences in the infiltration of BCC lesions with cells of the adaptive and innate immune system. Epidermal activation of Hh/Gli signaling led to an accumulation of immunosuppressive regulatory T cells, and to an increased expression of immune checkpoint molecules including programmed death (PD)-1/PD-ligand 1. Anti-PD-1 monotherapy, however, did not reduce tumor growth, presumably due to the lack of immunogenic mutations in common BCC mouse models, as shown by whole-exome sequencing. BCC lesions also displayed a marked infiltration with neutrophils, the depletion of which unexpectedly promoted BCC growth. The study provides a comprehensive survey of and novel insights into the immune status of murine BCC and serves as a basis for the design of efficacious rational combination treatments. This study also underlines the need for predictive immunogenic mouse models of BCC to evaluate the efficacy of immunotherapeutic strategies in vivo.
Jabba: hybrid error correction for long sequencing reads (2016)

Third generation sequencing platforms produce longer reads with higher error rates than second generation technologies. While the improved read length can provide useful information for downstream analysis, underlying algorithms are challenged by the high error rate. Error correction methods in which accurate short reads are used to correct noisy long reads appear to be attractive to generate high-quality long reads. Methods that align short reads to long reads do not optimally use the information contained in the second generation data, and suffer from large runtimes. Recently, a new hybrid error correcting method has been proposed, where the second generation data is first assembled into a de Bruijn graph, on which the long reads are then aligned. In this context we present Jabba, a hybrid method to correct long third generation reads by mapping them on a corrected de Bruijn graph that was constructed from second generation data. Unique to our method is the use of a pseudo alignment approach with a seed-and-extend methodology, using maximal exact matches (MEMs) as seeds. In addition to benchmark results, certain theoretical results concerning the possibilities and limitations of the use of MEMs in the context of third generation reads are presented. Jabba produces highly reliable corrected reads: almost all corrected reads align to the reference, and these alignments have a very high identity. Many of the aligned reads are error-free. Additionally, Jabba corrects reads using a very low amount of CPU time. From this we conclude that pseudo alignment with MEMs is a fast and reliable method to map long highly erroneous sequences on a de Bruijn graph.
Three-dimensional iterative reconstruction algorithms with attenuation and geometric point response correction (1991)

A three-dimensional iterative reconstruction algorithm which incorporates models of the geometric point response in the projector-backprojector is presented for parallel, fan, and cone beam geometries. The algorithms have been tested on an IBM 3090-600S supercomputer. The iterative EM reconstruction algorithm is 50 times longer with geometric response and photon attenuation models than without modeling these physical effects. An improvement in image quality in the reconstruction of projection data collected from a single-photon-emission computed tomography (SPECT) imaging system has been observed. Significant improvements in image quality are obtained when the geometric point response and attenuation are appropriately compensated. It is observed that resolution is significantly improved with attenuation correction alone. Using phantom experiments, it is observed that the modeling of the spatial system response imposes a smoothing without loss of resolution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Experimental Models of Pancreatitis (2014)

Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been known to be closely related to intracellular digestive enzyme activation. In contrast to acute pancreatitis, chronic pancreatitis is characterized by irreversible tissue damage such as acinar cell atrophy and pancreatic fibrosis that results in exocrine and endocrine insufficiency. Recently, many studies of chronic pancreatitis have been prompted by the discovery of the pancreatic stellate cell, which has been identified and distinguished as the key effector cell of pancreatic fibrosis. However, investigations into the pathogenesis and treatment of pancreatitis face many obstacles because of its anatomical location and disparate clinical course. Due to these difficulties, most of our knowledge on pancreatitis is based on research conducted using experimental models of pancreatitis. In this review, several experimental models of pancreatitis will be discussed in terms of technique, advantages, and limitations.
Heterogeneity of SARS-CoV-2 virus produced in cell culture revealed by shotgun proteomics and supported by genome sequencing (2021)

COVID-19 is the most disturbing pandemic of the past hundred years. Its causative agent, the SARS-CoV-2 virus, has been the subject of an unprecedented investigation to characterize its molecular structure and intimate functioning. While markers for its detection have been proposed and several diagnostic methodologies developed, its propensity to evolve and evade diagnostic tools and the immune response is of great concern. The recent spread of new variants with increased infectivity requires even more attention. Here, we document how shotgun proteomics can be useful for rapidly monitoring the evolution of the SARS-CoV-2 virus. We evaluated the heterogeneity of purified SARS-CoV-2 virus obtained after culturing in the Vero E6 cell line. We found that cell culture induces significant changes that are translated at the protein level, such changes being detectable by tandem mass spectrometry. Production of viral particles requires careful quality control which can be easily performed by shotgun proteomics. Although considered relatively stable so far, the SARS-CoV-2 genome turns out to be prone to frequent variations. Therefore, the sequencing of SARS-CoV-2 variants from patients reporting only the consensus genome after its amplification would deserve more attention and could benefit from more in-depth analysis of low level but crystal-clear signals, as well as complementary and rapid analysis by shotgun proteomics.
Tactile feedback in a computer mouse (2003)

The effectiveness of tactile feedback is studied in conveying screen information to the user is studied. An existing mouse design was modified to include a piezoelectric transducer which presents vibrations to the tip of the index finger when the cursor arrives at a screen target. To test the hypothesis that tactile feedback would effect a more efficient use of the mouse, a preliminary study was undertaken using a computer program which sequentially places targets randomly about the screen, with targets being assigned either tactile feedback or no feedback. One group in the study operated under conditions of normal visibility while a second group operated under conditions of reduced visibility. The results, with 2470 trials and 19 subjects indicate that, under conditions of reduced visibility, tactile feedback decreases response time by 0.10 seconds. It is concluded that despite this modest time gain, tactile feedback promises to be a useful modality for conveying screen information, especially in cases of visual impairment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>