gebhart/patrepeval huggingface dataset:
Data from Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC) (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case–control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m&lt;sup&gt;2&lt;/sup&gt; increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04–1.14; &lt;i&gt;P&lt;/i&gt; = 0.007]. We observed significant heterogeneity by study design (&lt;i&gt;P&lt;/i&gt; = 0.04), noting the BMI–multiple myeloma association only for population-based studies (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt; = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m&lt;sup&gt;2&lt;/sup&gt;; OR, 1.2; 95% CI, 1.1–1.3; &lt;i&gt;P&lt;/i&gt; = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;interaction&lt;/sub&gt; &lt;0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25–&lt;30 kg/m&lt;sup&gt;2&lt;/sup&gt;) or obese (30+ kg/m&lt;sup&gt;2&lt;/sup&gt;) in both younger and usual adulthood (vs. individuals consistently &lt;25 kg/m&lt;sup&gt;2&lt;/sup&gt;), but not for those overweight or obese at only one time period.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 26(6); 876–85. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Cervical softening occurs early in pregnancy: characterization of cervical stiffness in 100 healthy women using the aspiration technique (2013)

The aspiration method allows an objective description of the consistency of the ectocervix during pregnancy, indicating that the tissue softens already at the beginning of gestation, transforms continuously to lower consistency in the first two trimesters, stabilizes at a low level in the third trimester, and recovers its stiffness after delivery.
Assembly-oriented design: concepts, algorithms and computational tools (1998)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.
Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension (2012)

A proliferation of mast cells around the small pulmonary blood vessels and the alveolar septae has been noted in models of pulmonary hypertension, and in plexiform lesions of pulmonary arterial hypertension (PAH) in patients. Here, we hypothesize that total mast cell numbers and activation are increased in PAH and that they contribute to vascular remodeling through cellular and soluble proangiogenic effectors. To test this, blood and urine were collected from patients with PAH (N=44), asthma (N=18) and healthy controls (N=29) to quantitate biomarkers of total body mast cell numbers and activation (total and mature tryptase, N-methyl histamine, leukotriene LTE(4) and prostaglandin PGD-M). Serum total tryptase was higher in PAH than that in controls suggesting greater numbers of mast cells, but indicators of mast cell activation (mature tryptase, LTE(4) and PGD-M) were similar among PAH, asthma, and controls. Immunohistochemistry of lung tissues identified mast cells as primarily perivascular and connective tissue chymase(+) type in PAH, rather than mucosal phenotype. Intervention with mast cell inhibitors cromolyn and fexofenadine was performed in 9 patients for 12 weeks to identify the influence of mast cell products on the pathologic proangiogenic environment. Treatment decreased total tryptase and LTE-4 levels over time of treatment. This occurred in parallel to a drop in vascular endothelial growth factor (VEGF) and circulating proangiogenic CD34+CD133+ progenitor cells, which suggests that mast cells may promote vascular remodeling and dysfunction. In support of this, levels of exhaled nitric oxide, a vasodilator that is generally low in PAH, increased at the end of the 12-week mast cell blockade and antihistamine. These results suggest that mast cells might contribute to the pulmonary vascular pathologic processes underlying PAH. More studies are needed to confirm their potential contribution to the disease.
[Antimicrobial action spectrum of triterpene and steroid glycosides]. (1979)

Antimicrobial activity of 9 triterpene glycosides of the plant and animal origin was studied. It was found that saponins inhibited the fungal growth to different extents and had no activity against grampositive and gramnegative bacteria. Triterpene glycosides of the animal origin, i.e. holoturins A and B, stichoposids A and C had the most pronounced antifungal activity as compared to the saponins isolated from plants. Changes in the length of the carbon chain from 2 to 6 monosugars had no significant effect on the activity of the triterpeneglycosides studied.
Association of protein phosphatase 2A with polyoma virus medium tumor antigen. (1990)

The polyoma virus medium and small tumor antigens, as well as simian virus 40 small tumor antigen, form specific complexes with two cellular proteins designated 61- and 37-kDa proteins. In this report, we demonstrate that the 61- and 37-kDa proteins correspond to the A and C subunits, respectively, of the serine- and threonine-specific protein phosphatase 2A (PP2A). On the one hand, antibodies raised against the 61-kDa protein reacted specifically with the purified A subunit of PP2A. Furthermore, the amino acid sequences of seven tryptic peptides from the A subunit were almost identical to sequences of the 61-kDa protein as deduced from the corresponding cDNA sequence. On the other hand, antibodies against the purified C subunit (catalytic subunit) of PP2A reacted specifically with the medium tumor antigen-associated 37-kDa protein. These data suggest a role of PP2A in cell transformation by polyoma virus and simian virus 40.
Collagen Has a Discrete Family of Reactive Hydroxylysyl and Lysyl Side-Chain Amino Groups (1969)

Several cross-linking substances which derive from lysine have been isolated from hydrolyzates of collagen and elastin. This observation suggests that certain lysyl side chains exhibiting enhanced reactivity and unique configuration may participate in cross-linking. In native collagen there is a small family of lysyl and hydroxylysyl side chains which exhibit a high propensity of Schiff base formation.
The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties (2002)

Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40-45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.
Inflammatory bowel disease and refractory anaemia (myelodysplasia). (1993)

Two patients with colitis and refractory anaemia requiring multiple transfusions are described. In one the anaemia was detected at the onset of colitis before drug treatment; in the other it started after 21 years of treatment with sulphasalazine and during an exacerbation of colitis with perianal abscess for which he had just been started receiving prednisolone, cofluampicil and metronidazole. Glomerulonephritis developed two weeks after the onset of anaemia. These findings together with a recent report of four patients with Crohn's disease and refractory anaemia suggests that the association may be more than coincidental and may be immune mediated.
Stereoselective total syntheses of diterpene resin acids (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective total syntheses of diterpene resin acidsS. C. Welch, C. P. Hagan, J. H. Kim, and P. S. ChuCite this: J. Org. Chem. 1977, 42, 17, 2879–2887Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/jo00437a021https://doi.org/10.1021/jo00437a021research-articleACS PublicationsRequest reuse permissionsArticle Views345Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantifying the Diffusion of a Fluid through Membranes by Remote Detection MRI (2006)

We present a method to measure self-diffusion across membranes without the need for concentration or pressure gradients. Hyperpolarized xenon in combination with remote detection of NMR allows the measurement of membrane permeation, even in the gas phase. The resulting images allow quantification of the amount of fluid diffused through the membrane, and represent an alternative, potentially more precise way of measuring a membrane diffusion coefficient. The use of remote detection of NMR allows for non-invasive signal encoding coupled to sensitive detection, making this approach ideal for the study of diffusion in intact devices such as fuel cells or separation systems.
Vascular Catheters Inserted in the Trenches Versus Guideline Documents: Can the Discrepancies Be Resolved? (2003)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Thermodynamic and Physical Properties of Molten Potassium Polysulfides from Open‐Circuit Voltage Measurements (1982)

The open‐circuit voltage of the cell has been measured as a function of temperature and potassium polysulfide composition. The sulfur‐hexasulfide (two‐phase) emf is 2.414V at 250°C. A titration cell has been used to add or remove potassium from the polysulfide. The partial molar enthalpy of adding K to the polysulfide is −54.65 kcal/mol for the tetrasulfide. The solubility of sulfur in potassium hexasulfide has been determined between 225° and 325°C. The measured properties are essential to the further evaluation of the intermediate temperature potassium‐sulfur system for energy storage.
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS (2014)

Multifocal choroiditis/punctate inner choroidopathy can present with transient or permanent central photoreceptor attenuation/loss. This presentation is likely a variant of multifocal choroiditis/punctate inner choroidopathy with chorioretinal atrophy. Associated changes are best evaluated using multimodal imaging.
Multispectral Image Reconstruction From Color Images Using Enhanced Variational Autoencoder and Generative Adversarial Network (2020)

Since multispectral images (MSIs) have much more sufficient spectral information than RGB images (RGBs), reconstructing MS images from RGB images is a severely underconstrained problem. We have to generate colossally different information between the two scopes. Almost all previous approaches are based on static and dependent neural networks, which fail to explain how to supplement the massive lost information. This paper presents a low-cost and high-efficiency approach, “VAE-GAN”, based on stochastic neural networks to directly reconstruct high-quality MSIs from RGBs. Our approach combines the advantages of the Generative Adversarial Network (GAN) and the Variational Autoencoder (VAE). The VAE undertakes the generation of the lost variational MS distributions by reparameterizing the latent space vector with sampling from Gaussian distribution. The GAN is responsible for regulating the generator to produce MSI-like images. In this way, our approach can create huge missed information and make the outputs look real, which also solves the previous problem. Moreover, we use several qualitative and quantitative methods to evaluate our approach and obtain excellent results. In particular, with much less training data than the previous approaches, we obtained comparable results on the CAVE dataset and surpassed state-of-the-art results on the ICVL dataset.
Evaluating automated support for requirements similarity analysis in market-driven development (2001)

In market-driven software development, there is a considerable risk for congestion in the requirements engineering process, as the demand of short time-to-market is combined with a rapid arrival of new requirements from many different sources. Automated analysis of the continuous flow of incoming requirements provides an opportunity to increase the efficiency of the requirements engineering process. This paper presents empirical evaluations of the benefit of automated similarity analysis of textual requirements, where existing Information Retrieval techniques are used to statistically measure requirements similarity. The results show that automated analysis of similarity among textual requirements is a promising technique that may provide effective support in both requirements duplicate identification and requirements interdependency analysis.
Human hypertrophic scar‐like nude mouse model: Characterization of the molecular and cellular biology of the scar process (2011)

Hypertrophic scar (HTS) following thermal injury and other forms of trauma is a dermal fibroproliferative disorder that leads to considerable morbidity. Because of the lack of an ideal animal model, research is difficult. We have established an HTS model that involves transplanting human split-thickness skin graft (STSG) or full-thickness skin graft (FTSG) onto the backs of nude mice. The animals developed raised, firm, and reddish scars 2 months following transplantation. Histology and micromeasurement indicate raised, thickened engrafted skin with STSG and FTSG. In contrast, thickening was not observed with full-thickness rat skin grafts used as controls. Masson's trichrome staining demonstrates increased accumulations of collagen fibrils in the dermis in both scars grafted with STSG and FTSG. Staining cells with toludine blue and an antibody for F4/80 showed an increase in the infiltration of mast cells and macrophages. Quantification of fibrocytes reveals increased fibrocytes. Moreover, STSG grafted skin had significantly more macrophages, mast cells, and fibrocytes than FTSG. Real-time polymerase chain reaction analysis showed significantly elevated mRNA levels for type I collagen, transforming growth factor-β, connective tissue growth factor and heat shock protein 47 in both types of engrafted skin. These data demonstrate that human skin grafted onto nude mice develops red raised and thickened scars having intrinsic properties that closely resemble HTS formation as seen in humans. Interestingly, STSG developed more scar than FTSG. Furthermore, inflammatory cells and bone marrow-derived fibrocytes may play a critical role in HTS development in this animal model.
FSelector: a Ruby gem for feature selection (2012)

FSelector, written in the Ruby programming language, is free and open-source software that runs on all Ruby supporting platforms, including Windows, Linux and Mac OS X. FSelector is available from https://rubygems.org/gems/fselector and can be installed like a breeze via the command gem install fselector. The source code is available (https://github.com/need47/fselector) and is fully documented (http://rubydoc.info/gems/fselector/frames).
On the decay of small amounts of signal charge in surface-channel CCD's (1975)

By solving the continuity equation with the assumption that the signal charge is small, an expression is obtained for the decay of charge in a three-phase CCD having a short gate length. The results help clarify some previous results on this topic.
Impact of dietary lipid supplementation on goat milk fat and sensorial properties of cheeses (2004)

International audience
Volume and Temperature Dependences of the Global and Segmental Dynamics in Polymers:  Functional Forms and Implications for the Glass Transition (2005)

Previously, from dielectric relaxation measurements obtained for various temperatures T and pressures P on polypropylene glycol, 1,4-polyisoprene, and poly(oxybutylene) [Roland, C. M.; Casalini, R.; Paluch, M. J. Polym. Sci. Polym. Phys. Ed. 2004, 42, 4313. R. Casalini and C. M. Roland, Macromolecules, 2005, 38, 1779], both the primary α-relaxation time τα and the normal mode relaxation time τn were shown to yield master curves when plotted versus the quantity T-1V-γ . Moreover, the value of γ is the same for the two processes (here V is the specific volume and γ is a material-specific constant). Such a result appears to be consistent with an assumption underlying models for polymer viscoelasticity that the friction coefficient governing motions over large length scales can be identified with the local segmental friction coefficient. However, notwithstanding the superpositioning obtained using the same value of γ, τα and τn differ in their dependences on either the product variable T-1V-γ , V at constant T, or T at constant P. In each case, the difference is more pronounced at longer τα. Such behavior is inconsistent with the Rouse and tube models. However, these differences in the respective dependences of τα and τn can be accounted for quantitatively by the coupling model. The framework of the solution of the problem supports the proposal that the temperature and volume dependences of molecular mobility, which trigger the glass transition, do not originate from the primary α relaxation. Instead, they have their origin in the primitive relaxation of the coupling model.
Minimal region necessary for autonomous replication of pTAR (1988)

The native 44-kilobase-pair plasmid pTAR, discovered in a grapevine strain of Agrobacterium tumefaciens, contains a single origin of DNA replication confined to a 1.0-kilobase-pair region of the macromolecule. This region (ori) confers functions sufficient for replication in Agrobacterium and Rhizobium species but not in Pseudomonas solanacearum, Pseudomonas glumae, Pseudomonas syringae pv. savastanoi, Xanthomonas campestris pv. campestris, and Escherichia coli. ori contains a repA gene that encodes a 28,000-dalton protein required for replication. Nucleotide sequencing of repA and its promoter region revealed four 8-base-pair palindromic repeats upstream of the repA coding region. Deletion of these repeats alters repA expression and plasmid copy number. Downstream of repA are three additional repeats in a region essential for replication. A locus responsible for plasmid partitioning (parA) and a putative second locus regulating plasmid copy number are part of the origin region and are required for stable plasmid maintenance.
Wireless power transfer system based on high-index dielectric resonators (2016)

We have experimentally demonstrated two magnetic resonant wireless power transfer (WPT) systems based on dielectric spherical and disk resonators implemented with high permittivity microwave ceramics. We investigated the power transfer efficiency as a function of separation and rotation angle of the receiver and the transmitter with respect to one another. For the WPT system with spherical resonators, the maximal power transfer efficiency of 63% and 80% were obtained for the magnetic dipole mode and the magnetic quadrupole mode, respectively. With the matched impedance, the power transfer efficiency of the WPT system based on dielectric disk resonators can be as high as 80% for the separation less than 10 cm (2.4 radii of resonator) and more than 50% within separation of 16 cm (3.8 radii of resonator).
Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine (2020)

Precision medicine is one of the recent and powerful developments in medical care, which has the potential to improve the traditional symptom-driven practice of medicine, allowing earlier interventions using advanced diagnostics and tailoring better and economically personalized treatments. Identifying the best pathway to personalized and population medicine involves the ability to analyze comprehensive patient information together with broader aspects to monitor and distinguish between sick and relatively healthy people, which will lead to a better understanding of biological indicators that can signal shifts in health. While the complexities of disease at the individual level have made it difficult to utilize healthcare information in clinical decision-making, some of the existing constraints have been greatly minimized by technological advancements. To implement effective precision medicine with enhanced ability to positively impact patient outcomes and provide real-time decision support, it is important to harness the power of electronic health records by integrating disparate data sources and discovering patient-specific patterns of disease progression. Useful analytic tools, technologies, databases, and approaches are required to augment networking and interoperability of clinical, laboratory and public health systems, as well as addressing ethical and social issues related to the privacy and protection of healthcare data with effective balance. Developing multifunctional machine learning platforms for clinical data extraction, aggregation, management and analysis can support clinicians by efficiently stratifying subjects to understand specific scenarios and optimize decision-making. Implementation of artificial intelligence in healthcare is a compelling vision that has the potential in leading to the significant improvements for achieving the goals of providing real-time, better personalized and population medicine at lower costs. In this study, we focused on analyzing and discussing various published artificial intelligence and machine learning solutions, approaches and perspectives, aiming to advance academic solutions in paving the way for a new data-centric era of discovery in healthcare.