gebhart/patrepeval huggingface dataset:
The effect of ethyldeshydroxy-sparsomycin and cisplatin on the intracellular glutathione level and glutathione S-transferase activity (1997)

Ethyldeshydroxy-sparsomycin (EdSm) is a ribosomal protein synthesis inhibitor which synergistically enhances the antitumor activity of cisplatin against L1210 leukemia in vivo. Because cellular glutathione (GSH) and glutathione S-transferases (GST) are reported to interfere with the antitumor activity of cisplatin, we analyzed the effect of EdSm and cisplatin on GSH and GST activity in selected tumor cells. For this purpose we used three murine leukemia tumors with different sensitivities towards EdSm and cisplatin: L1210-WT, sensitive to both drugs, L1210-Sm, resistant to EdSm, and L1210-CDDP, resistant to cisplatin. No significant differences were detectable between these three cell lines regarding the population doubling time, the cell size, and the cellular level of protein and glutathione. Neither of the resistant L1210 subclones showed P-glycoprotein expression. Drug exposure, however, changed the intracellular dynamics. Exposure to EdSm strongly decreased the amount of cellular protein, decreased the overall GST activity and led to GSH depletion, whereas exposure to cisplatin induced a rise in the amount of protein, in GSH, and in the total GST activity. These effects are dose-dependent and correlate well with the sensitivity of the tumor cells for EdSm or cisplatin. In addition, exposure to EdSm lowered the V(max) of GST in L1210-WT and L1210-Sm; however, in L1210-CDDP both the V(max) and the K(m) were increased. That this was not a direct effect of EdSm on GST was shown in a cell-free system, where EdSm did not influence the GST activity nor could it act as a substrate for GST. Our results suggest that the synergistic combination of EdSm and cisplatin might be explained by EdSm switching off the cellular detoxification mechanism for cisplatin, i.e. by inhibition of de novo synthesis and subsequent depletion of GSH and GST.
Tutorial overview of model predictive control (2000)

The paper provides a reasonably accessible and self-contained tutorial exposition on model predictive control (MPC). It is aimed at readers with control expertise, particularly practitioners, who wish to broaden their perspective in the MPC area of control technology. We introduce the concepts, provide a framework in which the critical issues can be expressed and analyzed, and point out how MPC allows practitioners to address the trade-offs that must be considered in implementing a control technology.
Scanning electro-optical and pyroelectrical microscopy for the investigation of polarization patterns in poled polymers (1993)

Compact and simple experimental setups for scanning pyroelectrical and electro-optical microscopy are introduced. Their feasibility is demonstrated with scans of periodically poled layers of a nonlinear optical side-chain polymer. While the scanning pyroelectrical microscope has a less complex design and is easier to use, the scanning electro-optical microscope exhibits better spatial resolution and higher contrast. Both tools will be essential for optimizing the patterned poling of nonlinear optical waveguides, modulators, and sensors.
A Global Energetic Model for Microquasars: preliminary results and spectral energy distributions (2008)

We present preliminary results and observables from a model of microquasar based on a theoretical framework where stationary, powerful, compact jets are launched and then accelerated from an inner magnetized disk. This model aim at providing a consistent picture of microquasars in all their spectral states. It is composed of an outer standard accretion disk down to a variable transition radius where it changes to a magnetized disk, called the Jet Emitting Disk (JED). The theoretical framework providing the heating, we solve the radiative equilibrium and obtain the JED structure. Our JED solutions are rich, and reproduce the already known scheme where a cold optically-thick and a hot optically-thin solutions bracket a thermally unstable one. We present the model and preliminary results, whith a first attempt at reproducing the observed SED of XTE J1118+480.
Effect of tapered fiber structure on the PbS Nanomaterials optical fiber amplifier excited by evanescent wave (2019)

PbS nanomaterials fiber amplifier was fabricated by coating PbS nanomaterials onto tapered fiber. PbS is deposited by atomic layer deposition technique. The influence to optical properties is discussed when changing the structure of tapered fiber.
Experimental Studies and Verification of the Vertical Array-Differential Target Antenna Coupling (DTAC) Method for Rapid Sensing and Imaging of Subsurface Targets (2015)

Abstract We have developed a new electromagnetic geophysical system that has significantly improved target sensing and imaging capabilities compared to conventional measurements. In a previous series of papers, we described a new measurement technology called the Differential Target Antenna Coupling (DTAC) method, which used a magnetic-field transmitter (TX) and a magnetic-field receiver (RX), oriented in a horizontal array, with separation distances of the order of tens of meters, and up to tens of kilometers. In the present paper, we use the DTAC method in a vertical-array configuration, with the TX coil directly above two null-coupled RX coils. This vertical array provides a number of important advantages over the large-offset horizontal array for some applications. For example, the vertical array-DTAC method can be adapted to rapidly moving measurements, such as from a helicopter. In addition, the vertical array-DTAC method also suppresses surface clutter, such as fences, steel buildings, and parked vehicles. The DTAC method uses at least two frequencies. One frequency is used as a reference signal to establish the null direction at that frequency, and then a different frequency is used to measure the change in the null at the new frequency. We can also use an arbitrary number of frequencies with just one reference frequency for wide-bandwidth spectral measurements. We first describe the vertical array-DTAC measurement system and discuss the calibration procedure for the instrumentation. Next, we discuss the methods employed for scale-model testing of the system. We validate the vertical array-DTAC method using small-scale controlled tests and demonstrate the enhanced resolution and sensitivity of the vertical array-DTAC method. Suitable TX moments and frequency ranges can be selected for effective study of near-surface targets (civil engineering, water resource, and environmental characterization) as well as deep targets (mining and other natural-resource exploration).
Band lineup of a SnS2/SnSe2/SnS2 semiconductor quantum well structure prepared by van der Waals epitaxy (1999)

A quantum well composed of layered semiconductors and SnSe2 (Eg=1.03 eV) and SnS2 (Eg=2.18 eV) was grown in several steps by van der Waals epitaxy. After each growth step the electronic structure was characterized by ultraviolet and x-ray photoemission spectroscopy. From these measurements, bandbending and the valence-band offset were determined on both sides of the quantum well. The results show that both wells are of the same magnitude, hence indicating commutativity of the band offset. Small interface dipoles (0.11–0.19 eV) were detected at the interfaces, which could be identified as quantum dipoles.
Partitioning Tracer Tests for Characterizing Immiscible-Fluid Saturations and Interfacial Areas in the Vadose Zone (2003)

Contaminant-transport analyses, risk assessments, and site remediations are all constrained by the complexity of the subsurface environment and by our insufficient knowledge of that environment. Most current subsurface characterization methods provide measurements for very small spatial domains, such that they are essentially point values. While such methods can provide accurate and precise data for small scales, their use for characterizing larger domains is generally constrained by sample-size limitations. Thus, methods that provide measurements at larger scales are being developed to complement the point-sampling methods. One such group of methods is based on the use of tracer tests. This review will cover “partitioning” tracer tests, which can be used to measure immiscible-liquid saturation of organic contaminants, soil water content, and fluid–fluid interfacial areas in subsurface systems. The conceptual basis and implementation of these methods will be briefly reviewed, with a focus on vadose zone applications.
Supplementary Figure 6 from YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer (2023)

&lt;p&gt;Supplementary figure related to figure 6. Supplementary Fig. 6. YAP controls β-catenin activity.&lt;/p&gt;
A self-adaptive RIS that estimates and shapes fading rich-scattering wireless channels (2022)

We present a framework for operating a self-adaptive RIS inside a fading rich-scattering wireless environment. We model the rich-scattering wireless channel as being double-parametrized by (i) the RIS, and (ii) dynamic perturbers (moving objects, etc.). Within each coherence time, first, the self-adaptive RIS estimates the status of the dynamic perturbers (e.g., the perturbers’ orientations and locations) based on measurements with an auxiliary wireless channel. Then, second, using a learned surrogate forward model of the mapping from RIS configuration and perturber status to wireless channel, an optimized RIS configuration to achieve a desired functionality is obtained. We demonstrate our technique using a physics-based end-to-end model of RIS-parametrized communication with adjustable fading (PhysFad) for the example objective of maximizing the received signal strength indicator. Our results present a route toward convergence of RIS-empowered localization and sensing with RIS-empowered channel shaping beyond the simple case of operation in free space without fading.
Interplay of Bright Triplet and Dark Excitons Revealed by Magneto‐Photoluminescence of Individual PbS/CdS Quantum Dots (2021)

A low-temperature polarization-resolved magneto-photoluminescence experiment is performed on individual PbS/CdS core/shell quantum dots (QDs). The experiment enables a direct measurement of the exciton Landé g factor and the anisotropic zero-field splitting of the lowest emissive bright exciton triplet in PbS/CdS QDs. While anisotropic splittings of individual QDs distribute randomly in 104-325 μeV range, the exciton Landé g factors increase from 0.95 to 2.70 as the emission energy of the QD increases from 1.0 to 1.2 eV. The tight-binding calculations allow to rationalize these trends as a direct consequence of reducing a cubic symmetry of QD via addition/removal of a few (<70) atoms from the surfaces of the PbS core. Furthermore, it is observed that while right (σ <sup>+</sup> ) and left (σ <sup>-</sup> ) circularly polarized photoluminescence (PL) peaks split linearly with magnetic field as expected for Zeeman effect, the energy splitting between X and Y linearly polarized PL peaks remains nearly unchanged. The theoretical study reveals rich and complex magnetic field-induced interplay of bright triplet and dark exciton states explaining this puzzling behavior. These findings fill the missing gaps in the understanding of lead salt QDs and provide foundation for development of classical and quantum light sources operating at telecommunication wavelengths.
Availability-Based Distribution Circuit Design for Shipboard Power System (2015)

The electric distribution circuit design problem has been primarily approached from the perspective of minimizing circuit losses. Motivated by the requirement for higher service continuity, we propose a graph theory based approach for the distribution circuit design problem. A mathematical formulation for designing a resilient circuit topology aiming to minimize the number of conductors while satisfying a given network availability constraint is developed first. A computationally efficient algorithm, termed successive minpath generation to solve the formulated topology design problem is proposed next. The proposed algorithm reduces the double exponential search space for the resilient circuit topology to polynomial time allowing a tractable solution for the topology design problem. The algorithm is applied to design the circuit topology for the zonal electric distribution (ZED) circuit of an all-electric ship supplied by single as well as multiple power sources. Compared with grid topology, the proposed approach results in circuit topologies with network availability more than 0.99 by using 3 fewer and 12 fewer conductors for a 15-node and a 30-node ZED, respectively.
Studies on Antibiotics Produced by Psychrophilic Microorganisms (1971)

A screening for antibacterial antibiotics was carried out with psychrophilic microorganisms. The most active microorganism, a soil actinomycete, was selected and characterized to be a facultative psychrophile, Streptomyces sp. No. 81. This strain was found to produce antibiotic(s) in the culture fluid only at low temperature cultivation below 20°C but not at moderate temperature. Mycelial growth at low temperature seemed to be indispensable for the antibiotic production. The antibiotic produced by Streptomyces sp. No. 81 was isolated and characterized. It appeared that the antibiotic had the selective toxicity against several Gram-positive bacteria. From the comparative studies with several known antibiotics, the antibiotic appears to be a new compound derived from the new metabolic routes involving temperature-sensitive mechanisms.
Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease. (1978)

Isolated simian virus 40 (SV40) and polyoma nucleoprotein complexes contain endonuclease that, under in vitro conditions, converts part (up to 30%) of the covalently closed superhelical DNA to full-length linear rods. The positions of the cleavage sites within the genomes of SV40 and polyoma were determined by digestion with various single-cut restriction endonucleases and subsequent agarose gel electrophoresis of the cleavage products. Both SV40 and polyoma covalently closed superhelical DNA were cleaved open at their respective origins of DNA replication (+/- 75 base pairs). The full-length linear DNA rods whose ends map adjacent to the origin of DNA replication could also be isolated by sodium dodecyl sulfate/phenol extraction both from SV40-infected permissive cells and from purified SV40 virions. These data reveal the presence of a unique structure of the papovavirus chromatin close to the initiation site of DNA replication.
Global adjustment for creating extended panoramic images in video-dermoscopy (2017)

Published in Clinical and Preclinical Optical Diagnostics, J. Quincy Brown, ed., SPIE Proceedings , Vol. 10411, paper 104110O, 2017
Simultaneous Detection of Morphine and Codeine in the Presence of Ascorbic Acid and Uric Acid and in Human Plasma at Nafion Single-Walled Carbon Nanotube Thin-Film Electrode (2019)

In clinical settings, the dosing and differential diagnosis of the poisoning of morphine (MO) and codeine (CO) is challenging due to interindividual variations in metabolism. However, direct electrochemical detection of these analytes from biological matrices is inherently challenging due to interference from large concentrations of anions, such as ascorbic acid (AA) and uric acid (UA), as well as fouling of the electrode by proteins. In this work, a disposable Nafion-coated single-walled carbon nanotube network (SWCNT) electrode was developed. We show facile electron transfer and efficient charge separation between the interfering anions and positively charged MO and CO, as well as significantly reduced matrix effect in human plasma. The Nafion coating alters the voltammetric response of MO and CO, enabling simultaneous detection. With this SWCNT/Nafion electrode, two linear ranges of 0.05-1 and 1-10 μM were found for MO and one linear range of 0.1-50 μM for CO. Moreover, the selective and simultaneous detection of MO and CO was achieved in large excess of AA and UA, as well as, for the first time, in unprocessed human plasma. The favorable properties of this electrode enabled measurements in plasma with only mild dilution and without the precipitation of proteins.
Comparative structural analysis of staphylococcal enterotoxins A and E (1989)

Structural analysis of staphylococcal enterotoxins A and E, two functionally and serologically related proteins, has been carried out using circular dichroism, and tryptophan fluorescence quantum yield and quenching. Secondary structures derived from the far-UV circular dichroic spectra revealed that both enterotoxins are in predominantly beta-sheets/beta-turn structures (80-85%). Staphylococcal enterotoxin A has significantly higher alpha-helical content (10.0%) than staphylococcal enterotoxin E (6.5%). Tryptophan fluorescence spectra of both enterotoxins showed maxima at approximately 342 nm, indicating that the fluorescent tryptophan residues are in polar environments. However, the tryptophan fluorescence quantum yields indicated that tryptophan residues are approximately 41% more fluorescent in staphylococcal enterotoxin A than in staphylococcal enterotoxin E. Tryptophan fluorescence quenching by a surface quencher, I-, and a neutral quencher, acrylamide, indicated that at least 1 of the 2 tryptophan residues in both staphylococcal enterotoxins A and E is located on the outer surface of the proteins. This tryptophan residue is in significantly different environments in the two enterotoxins. Six antigenic sites are predicted from the hydrophilicity and secondary structure information; at least four sites are identical. In general, staphylococcal enterotoxins A and E have some structural similarities which are compatible with their common biological activities.
FRP Piping Design with the Aid of the Similarity Law (1987)

The conventional analysis of FRP piping with respect to an internal pressing, bending, and compressing destruction have been made on the basis of an elastic analysis just as the case of a metal, an isotropic elastic material. The errors introduced in calculation were noticeable and it was difficult to calculate the specific destruction strength of the FRP piping. In this report, the approximate strength analysis with the help of the similarity low is explained. By using this method, the strength of FRP pipes of same laminate materials and laminate structure with different diameters can be predicted by a less experiment. In addition, the strength of the three-point bending, internal pressing and compressing destruction were calculated by the experiment, and these results were examined. Further, the designing method of FRP piping with the help of the similarity low is described after briefly reviewing the conventional method of the strength analysis of FRP piping.
Versatile Fluorinated Derivatives of Triphenylamine as Hole-Transporters and Blue-Violet Emitters in Organic Light-Emitting Devices (2012)

A series of triphenylamine derivatives end-capped with various fluorinated phenyl (TPAF) have been designed and synthesized for the application in organic light-emitting devices (OLEDs). By changing the substitution pattern of electron-withdrawing groups, such as F and CF3, the ability of hole-transport, energy levels, and thermal stability of these, TPAF are tuned, which are supported by density functional study of their geometry and electronic structure. TPAF can be used as either hole-transporters or blue-violet emitters in OLEDs. Among TPAF, the device with TPA-(2)-F as hole-transport material achieved the maximum current efficiency of 4.7 cd A–1, which was much higher than that of the typical N,N′-di(1-naphthalenyl)-N,N′-diphenyl-4,4′-diamine-based device. This good performance of the TPA-(2)-F-based device was attributed to the more balanceable injected carriers in the device by tuning hole injection and transport. More importantly, nondoped blue OLEDs utilizing TPAF as the emitters exhibited blue-violet emissions peaking between 408 and 428 nm with Commission Internationale de L’Eclairage coordinates in a range of (0.16–0.18, 0.06–0.12), which were also expected to be a new material class with an enhanced current efficiency/color purity compromise for future blue light-emitting devices.
The heavy molecule-aerosol analogy, and the dispersion of sound by gas mixtures of disparate masses (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe heavy molecule-aerosol analogy, and the dispersion of sound by gas mixtures of disparate massesJ. Fernandez de la MoraCite this: J. Phys. Chem. 1984, 88, 20, 4557–4560Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/j150664a022https://doi.org/10.1021/j150664a022research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A method for estimating hepatitis B virus incidence rates in volunteer blood donors. National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study (1997)

The crude HBV incidence rate observed from HBsAg test results will underestimate the true rate. The adjusted HBV incidence rate should be used in applications such as estimations of residual HBV risk to the blood supply and projections of the benefits of screening for HBV DNA.
Mercury: Organometallic ChemistryBased in part on the article Mercury: Organometallic Chemistry by Richard C. Larock which appeared in the Encyclopedia of Inorganic Chemistry, First Edition . (2005)

Abstract Over the past 10 years, a wide range of new organomercury compounds have been prepared and their reactivity extensively studied, leading to interesting applications in organic synthesis. The solvomercuration of alkenes is still the most widely employed organometallic reaction of mercury, although there have been important advances in the use of the mercury‐mediated ring opening of cyclopropanes. Several structural investigations of organomercurials have been recently carried out providing detailed information on the connectivity of a wide range of mono‐ and polymercuric complexes. In this article, an overview of the most important advances on the organometallic chemistry of mercury between 1993 and 2003 will be provided.