gebhart/patrepeval huggingface dataset:
Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer (2019)

Pancreatic ductal adenocarcinoma (PDAC) displays a marked fibro-inflammatory microenvironment in which infiltrated immune cells fail to eliminate the tumor cells and often-rather paradoxically-promote tumor progression. Of special interest are tumor-promoting T cells that assume a Th17-like phenotype because their presence in PDAC tissue is associated with a poor prognosis. In that context, the role of IL-21, a major cytokine released by Th17-like cells, was assessed. In all tissue samples (n = 264) IL-21<sup>+</sup> immune cells were detected by immunohistochemistry and high density of those cells was associated with poor prognosis. In the majority of patients (221/264), tumor cells expressed the receptor for IL-21 (IL-21R) and also a downstream target of IL-21, Blimp-1 (199/264). Blimp-1 expression closely correlated with IL-21R expression and multivariate analysis revealed that expression of both IL-21R and Blimp-1 was associated with shorter survival time of the patients. In vitro data using pancreatic tumor cells lines provided a possible explanation: IL-21 activated ERK and STAT3 pathways and upregulated Blimp-1. Moreover, IL-21 increased invasion of tumor cell lines in a Blimp-1-dependent manner. As an in vivo correlate, an avian xenograft model was used. Here again Blimp-1 expression was significantly upregulated in IL-21 stimulated tumor cells. In summary, our data showed an association of IL-21<sup>+</sup> immune cell infiltration and IL-21 receptor expression in PDAC with poor survival, most likely due to an IL-21-mediated promotion of tumor cell invasion and enhanced colony formation, supporting the notion of the tumor-promoting abilities of the tumor microenvironment.
Black TiO2 Nanoparticle/Carbonized Melamine Sponge Photothermal Conversion Layers for Improved Low-Temperature Performance of Supercapacitors (2023)

Energy storage devices for example supercapacitors suffer from severe capacitance decay at low temperature, which limits their application in extreme conditions. In spite of great efforts dedicated to develop a low-temperature-resistant electrolyte, the problem is still not solved satisfactorily. In this work, to address the problem, black TiO2/carbonized melamine sponge (CMF) was designed and prepared by adjusting the band gap of TiO2 nanoparticles due to the excellent photothermal conversion ability of black TiO2 nanoparticles. Benefiting from its excellent photothermal conversion ability, the performance of flexible supercapacitors at low temperatures has been greatly improved. A supercapacitor based on activated carbon electrodes is encapsulated in black TiO2/CMF serving as a photothermal conversion layer at low temperature. The specific capacitance of a supercapacitor is improved by 287.67% at −15 °C and improved by 187.51% at −50 °C under solar illumination. The proposed photothermal conversion material in this work shows great potential under a low-temperature environment and can be extended to other energy storage devices.
Transcriptomic analysis uncovers metabolic and ROS signaling alterations in preclinical models of enzalutamide resistance (2016)

status: Published
Laparoscopic surgery in obese women (1999)

Operative laparoscopy is safe and feasible in women with high BMIs. Although there is an increased chance of procedure conversion to laparotomy in these women, the morbidity and length of hospitalization associated with the procedure are similar to those among women with low BMIs.
Analysis of path-losses along the Kankberg tunnel with comparisons between LTE measurements and radio-channel measurements : A report to the PIMM project (2017)

In this report we present evaluations of path-losses along the 1 km long, and almost straight, tunnel-ramp located in the Kankberg underground mine outside Boliden, Sweden. From nine different LTE measurements along the ramp in the 1800 MHz frequency band in front of the mRRU antenna and when no vehicle is obstructing the signal path, the estimated path-loss exponents range between n = 1:40 and n = 2:19. When a large vehicle obstructs the signal path the estimated path-loss exponents from seven dierent measurements vary between n = 2:00 and n = 2:52. These values match quite well with an estimated path-loss exponent of n = 2:1 for corresponding, but quite differently measured, radio-channel measurements at1900 MHz. Behind the mRRU antenna, where the power is radiated in a much wider angle in the tunnel than in front of the antenna, the estimated path-loss coeffcients are much higher and vary between n = 4:4 and 5:2. Because of the relatively low attenuation measured in front of the antennas there is likely a wave-guide effect in the tunnel, even at these 1800/1900 MHz frequencies. A hypothesis is presented in Section 5 about how the waveguide effect is generated in the tunnel due to the antenna directivity, which is supported by the measurements.
Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells (2011)

The level of IDO activity in the plasma is not regulated through the expression of IDO1 or IDO2 in the peripheral blood mononuclear cells.
Photothermal Decomposition of Mixed Silver and Mercurous Oxalates. (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotothermal Decomposition of Mixed Silver and Mercurous Oxalates.Lawrence Suchow and Seymour L. HershCite this: J. Phys. Chem. 1953, 57, 4, 437–439Publication Date (Print):April 1, 1953Publication History Published online1 May 2002Published inissue 1 April 1953https://pubs.acs.org/doi/10.1021/j150505a010https://doi.org/10.1021/j150505a010research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Radar Cross Section (RCS) of HIS-based Microstrip Patch Array: Parametric Analysis (2018)

Low profile structures such as High Impedance Surfaces (HIS) are capable of modifying the scattering properties of a radiating structure. This paper presents the novel design of patch antenna/array with non-uniform HIS based ground plane. Two FSS elements of different dimensions are designed with different resonant frequencies. The performance of the high impedance surfaces has been carried out by varying the HIS dimensions and height of the substrate. Using the analyses, patch antenna/array with ground plane based on non-uniform configurations of HIS elements are designed. The radiation and scattering characteristics of microstrip patch antenna/array with HIS- based ground plane are compared to those with conventional PEC-based ground plane. A maximum of 8 dB RCS reduction has been achieved for patch array with non-uniform HIS layer.
Hydrophobicity and Conformational Change as Mechanistic Determinants for Nonspecific Modulators of Amyloid β Self-Assembly (2011)

The link between many neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, and the aberrant folding and aggregation of proteins has prompted a comprehensive search for small organic molecules that have the potential to inhibit such processes. Although many compounds have been reported to affect the formation of amyloid fibrils and/or other types of protein aggregates, the mechanisms by which they act are not well understood. A large number of compounds appear to act in a nonspecific way affecting several different amyloidogenic proteins. We describe here a detailed study of the mechanism of action of one representative compound, lacmoid, in the context of the inhibition of the aggregation of the amyloid β-peptide (Aβ) associated with Alzheimer's disease. We show that lacmoid binds Aβ(1-40) in a surfactant-like manner and counteracts the formation of all types of Aβ(1-40) and Aβ(1-42) aggregates. On the basis of these and previous findings, we are able to rationalize the molecular mechanisms of action of nonspecific modulators of protein self-assembly in terms of hydrophobic attraction and the conformational preferences of the polypeptide.
A New Tight Upper Bound on the Entropy of Sums (2015)

We consider the independent sum of a given random variable with a Gaussian variable and an infinitely divisible one. We find a novel tight upper bound on the entropy of the sum which still holds when the variable possibly has an infinite second moment. The proven bound has several implications on both information theoretic problems and infinitely divisible noise channels’ transmission rates.
Wireless Precision Piezoelectric Thermometer Using an RF Excitation-Detection Technique with an NMR Probe (1994)

Based on an inductive RF excitation-detection scheme, a quartz-crystal temperature-measuring device is described for applications in MRI and MRS scanners where strong electric and magnetic fields are present. A quartz-crystal resonator with a high temperature sensitivity (88 ppm/degrees C) is employed as the temperature sensor. Changes in the quartz resonance frequency reflecting temperature variations are detected by a NMR coil multiply tuned to the resonance frequencies of the quartz crystal and the nuclei of interest. This wireless probe is simple to build and is capable of measuring temperature changes from -50 to +150 degrees C. The high frequency linearity of the device in this temperature region ensures a simple calibration procedure and a constant temperature resolution.
Climatic Ageing Of Organic Fiber Reinforced Plastics: Water Effect (1997)

Abstract Climatic stability of 14 organic fiber reinforced plastics for aerospace applications developed at the All-Russian Institute of Aviation Materials was studied. Plastics were exposed for 5–10 years under warm humid climatic conditions of the city of Batumi on the Black Sea Coast. It has been proven that observed changes in the strain-stress properties of organic fiber reinforced plastics result from the fact that moisture causes the following effects: reversible plasticization effect, change in structural heterogeneity of the epoxy binders, active postcuring of the epoxy binders, plasticization effect of the SVM-fiber. Key Words: Plasticscompositesorganic fibersageinghumidity properties
Nitration of Benzene (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitration of BenzeneDonald F. Othmer, Joseph J. Jacobs Jr., and Joseph F. LevyCite this: Ind. Eng. Chem. 1942, 34, 3, 286–291Publication Date (Print):March 1, 1942Publication History Published online1 May 2002Published inissue 1 March 1942https://pubs.acs.org/doi/10.1021/ie50387a007https://doi.org/10.1021/ie50387a007research-articleACS PublicationsRequest reuse permissionsArticle Views1089Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Electrical stimulation to accelerate wound healing (2013)

Electrical stimulation has been shown to accelerate wound healing and increase cutaneous perfusion in human studies. Electrical stimulation is an adjunctive therapy that is underutilized in plastic surgery and could improve flap and graft survival, accelerate postoperative recovery, and decrease necrosis following foot reconstruction.
Magnifying Endoscopy with Blue Laser Imaging Improves the Microstructure Visualization in Early Gastric Cancer: Comparison of Magnifying Endoscopy with Narrow-Band Imaging (2017)

ME-BLI could better visualize the microstructures of the EGCs with shallow crypts compared with ME-NBI. Therefore, ME-BLI could enable a more accurate diagnosis of EGC with shallow crypts.
Abstract 558: Clinical Significance of Papillary Muscle Abnormalities in Hypertrophic Cardiomyopathy Identified by Cardiovascular Magnetic Resonance (2007)

Background. Increased thickness of the left ventricular (LV) wall is the predominant feature of the hypertrophic cardiomyopathy (HCM) phenotype. However, the structural characteristics of the LV pa...
Jazz: An Extensible 2D+Zooming Graphics Toolkit in Java (1999)

Jazz is a new general-purpose toolkit that supports applications using zooming object-oriented 2D graphics. It is built entirely in Java using Java2D, and thus runs on all platforms that support Java 2. It supports zooming, internal cameras, and lenses in a similar style to Pad++, but does so in a general purpose manner without a specific focus on zooming. Jazz is primarily a &amp;amp;quot;scenegraph &amp;amp;quot; for 2D graphics that is analogous to Sun&amp;apos;s Java3D and SGI&amp;apos;s OpenInventor in their support for 3D scenegraphs. This paper describes Jazz and discusses the issues of using a scenegraph for 2D graphics. We discuss the Jazz architecture, and how applications can build on top of it.
Cardiac hybrid imaging (2011)

Computed tomography coronary angiography (CTCA) and myocardial perfusion imaging techniques (single photon emission computed tomography, SPECT, or positron emission tomography, PET) are established non-invasive modalities for the diagnosis of coronary artery disease (CAD). Cardiac hybrid imaging consists of the combination (or 'fusion') of both modalities and allows obtaining complementary morphological (coronary anatomy, stenoses) and functional (myocardial perfusion) information in a single setting. However, hybrid cardiac imaging has also generated controversy with regard to which patients should undergo such integrated examinations for clinical effectiveness and minimization of costs and radiation dose. The feasibility and clinical value of hybrid imaging has been documented in small cohort studies and selected series of patients. Hybrid imaging appears to offer superior diagnostic and prognostic information compared with stand-alone or side-by-side interpretation of data sets. Particularly in patients with multivessel disease, the hybrid approach allows identification of flow-limiting coronary lesions and thereby provides useful information for the planning of revascularization procedures. Furthermore, integration of the detailed anatomical information from CTCA with the high molecular sensitivity of SPECT and PET may be useful to evaluate targeted molecular and cellular abnormalities in the future. While currently still restricted to specialized cardiac centres, the ongoing efforts to reduce radiation exposure and the increasing clinical interest will further pave the way for an increasing use of cardiac hybrid imaging in clinical practice.
Degradation kinetics of rebaudioside A in various buffer solutions (2013)

Summary Rebaudioside A is a noncaloric high‐intensity sweetener extracted from S tevia rebaudiana . For it to be used in foods, rebaudioside A needs to be stable during processing and storage. This study evaluated the kinetics of rebaudioside A degradation in 0.02 and 0.1 m citrate and phosphate buffer solutions at pH 3, 5 and 7 stored at 20, 30 and 40 °C for 9 months. At pH 3 and temperatures less than 30 °C, degradation was slow (i.e. less than 6% loss in 6 months) and not affected by buffer type or buffer concentration. At pH 7, the degradation of rebaudioside A increased dramatically in phosphate buffer (losses of up to 25% in 6 months at 30 °C), while remaining relatively slow in citrate buffer (less than 5% loss). The degradation rates at pH 7 increased 2.6 times as the concentration of phosphate buffer increased. For optimum stability of beverages containing rebaudioside A , formulations with lower concentrations of citrate buffer stored at lower temperatures are recommended.
DEAP: evolutionary algorithms made easy (2012)

Laboratoire de vision et systèmes numériques Département de génie électrique et de génie informatique
Optimal read/write memory system components (1972)

Two holographic data storage and display systems, voltage gradient ionization system, and linear strain manipulation system are discussed in terms of creating fast, high bit density, storage device. Components described include: novel mounting fixture for photoplastic arrays; corona discharge device; and block data composer.
Digital image watermarking : hiding information in images (1999)

These Ecole polytechnique federale de Lausanne EPFL, n° 2054 (1999)Faculte des sciences et techniques de l'ingenieurInstitut de genie electrique et electroniqueLaboratoire de traitement des signaux 1Jury: Touradj Ebrahimi, Freddy Gardiol, Alexander Herrigel, Benoit Macq, Daniel Mlynek, Thierry Pun Public defense: 1999-10-7 Prix EPFL de doctorats - EPFL doctorate award, 1999 Reference doi:10.5075/epfl-thesis-2054Print copy in library catalog Award: http://vpaa.epfl.ch/page14975-fr.html Record created on 2005-03-16, modified on 2016-08-08
Ciprofloxacin versus cinoxacin in therapy of urinary tract infections. A randomized, double-blind trial. (1987)

In a prospective, randomized, double-blind trial, ciprofloxacin (250 mg orally, twice daily) was compared with cinoxacin (500 mg orally, twice daily) in 60 patients with urinary tract infections. Most patients were women with uncomplicated urinary tract infections. Escherichia coli was the most common isolate (36 patients). Clinical and microbiologic cure occurred in 20 of 24 (83 percent) evaluable patients treated with ciprofloxacin, compared with 15 of 21 (71 percent) evaluable patients treated with cinoxacin. Ciprofloxacin was well tolerated and had a low incidence of minor side effects that included Candida vaginitis, headache, and gastrointestinal intolerance. Relapse or failed therapy was not associated with the development of resistance.
Design and implementation of neural networks for digital current regulation of inverter drives (2002)

A discussion is presented of the design of one, two, and three layer neural networks for digital current regulation of the inverter drives. The learning requirements of various designs are evaluated by developing two different learning techniques for such inverter current regulators. The models and learning techniques have been investigated by simulation. These simulation results along with design considerations are used to determine the network best suited for this application. The implementation of neural networks is described, and experimental results are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Thermodynamic Role of the Pro Region of the Neurophysin Precursor in Neurophysin Folding:  Evidence from the Effects of Ligand Peptides on Folding (1996)

Attention has focused recently on the role of amino-terminal precursor pro regions in protein folding, with particular emphasis on their effects on folding kinetics. We examined the kinetic and thermodynamic effects of ligand peptides on the folding of neurophysin from the reduced state; these peptides serve as analogs of the pro regions of the common precursors of the neurophysins and the hormones oxytocin and vasopressin. Folding of reduced, mononitrated bovine neurophysin-II was monitored by circular dichroism in a glutathione redox buffer. The results confirmed the ability of neurophysin to fold to a limited extent (20-25% in this system) in the absence of ligand peptides. Ligand peptides increased the efficiency of folding to 100%, the exact efficiency being dependent on peptide identity and concentration. However, the rate of folding was peptide-independent. Analysis of the folding reaction demonstrated relatively rapid conversion of the reduced state to a disulfide-scrambled state, which slowly converted (half-life of 5 h at pH 7.3) to the folded state. Native unliganded neurophysin also equilibrated with the disulfide-scrambled state in the same redox buffers. For each peptide, an equilibrium constant for the folding reaction, representing the amount of peptide bound in the folding system as a function of peptide concentration, was calculated. Comparison of this constant with the intrinsic binding constants of the native protein allowed the derivation, under conditions at or approaching thermodynamic reversibility, of the relative stability of the native and disulfide-scrambled states. The results indicate that the scrambled state, which probably represents the presence of incorrect disulfide pairs in both protein domains, is more stable than the native unliganded state by approximately 1 kcal/mol in this system. The role of ligand peptide therefore is to stabilize the folded protein after it is formed, i.e., it provides a thermodynamic sink. The results contrast with the putative behavior of exogenous peptides representative of the pro regions of subtilisin and alpha-lytic protease, which are generally considered to facilitate folding by reaction with folding intermediates. A potential alternative view of the role of propeptides in protease folding is suggested.
Model-Based and Model-Free Control of Autocorrelated Processes (1995)

Advances in automated sampling technology have made autocorrelated data commonplace. Positive autocorrelation degrades control charts designed by classical methods. If a correct time-series model of the autocorrelated process is available, many have advocated the use of control charts on the residuals from the model. Using the average run length criterion in an AR(1) model, we show that plotting averages of batches of the raw data can be an effective alternative to plotting residuals. We consider both weighted averages and the simple, model-free approach of arithmetic averages. We compare these statistics to residuals in both Shewhart and cumulative sum (CUSUM) control charts.