gebhart/patrepeval huggingface dataset:
Migraine Surgery: A Plastic Surgery Solution for Refractory Migraine Headache (2010)

Migraine headache can be a debilitating condition that confers a substantial burden to the affected individual and to society. Despite significant advancements in the medical management of this challenging disorder, clinical data have revealed a proportion of patients who do not adequately respond to pharmacologic intervention and remain symptomatic. Recent insights into the pathogenesis of migraine headache argue against a central vasogenic cause and substantiate a peripheral mechanism involving compressed craniofacial nerves that contribute to the generation of migraine headache. Botulinum toxin injection is a relatively new treatment approach with demonstrated efficacy and supports a peripheral mechanism. Patients who fail optimal medical management and experience amelioration of headache pain after injection at specific anatomical locations can be considered for subsequent surgery to decompress the entrapped peripheral nerves. Migraine surgery is an exciting prospect for appropriately selected patients suffering from migraine headache and will continue to be a burgeoning field that is replete with investigative opportunities.
Bio‐Inspired Synthesis of Minerals for Energy, Environment, and Medicinal Applications (2012)

Abstract Biomineralization, the natural pathway of assembling biogenic inorganic compounds, inspires us to exploit unique, effective strategies to fabricate functional materials with intricate structures. In this article, the recent advances in bio‐inspired synthesis of minerals—with a focus on those of calcium‐based minerals—and their applications to the design of functional materials for energy, environment, and biomedical fields are reviewed. Biomimetic mineralization is extending its application range to unconventional area such as the design of component materials for lithium‐ion batteries and elaborately structured composite materials utilizing carbon dioxide gas. Materials with highly enhanced mechanical properties are synthesized through emulating the nacre structure. Studies of bioactive minerals‐carbon hybrid materials show an expansion of potential applications to fields ranging from interdisciplinary science to practical engineering such as the fabrication of reinforced bone‐implantable materials.
Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERα-Dependent and -Independent Manners (2012)

Lysine specific demethylase 1 (LSD1, also known as KDM1) is a histone modifying enzyme that regulates the expression of many genes important in cancer progression and proliferation. It is present in various transcriptional complexes including those containing the estrogen receptor (ER). Indeed, inhibition of LSD1 activity and or expression has been shown to attenuate estrogen signaling in breast cancer cells in vitro, implicating this protein in the pathogenesis of cancer. Herein we describe experiments that utilize small molecule inhibitors, phenylcyclopropylamines, along with small interfering RNA to probe the role of LSD1 in breast cancer proliferation and in estrogen-dependent gene transcription. Surprisingly, whereas we have confirmed that inhibition of LSD1 strongly inhibits proliferation of breast cancer cells, we have determined that the cytostatic actions of LSD1 inhibition are not impacted by ER status. These data suggest that LSD1 may be a useful therapeutic target in several types of breast cancer; most notably, inhibitors of LSD1 may have utility in the treatment of ER-negative cancers for which there are minimal therapeutic options.
High-pressure xenon gamma-ray spectrometers: recent developments and applications (1999)

One of the most challenging and topical problems in modern gamma-ray spectroscopy is the need for thermally stable, high-resolution detectors. Temperature variations affect sensitive performance parameters in existing spectrometers such as leakage current in semiconductor photo-conductors and light output in scintillation-based spectrometers. For this reason, commercial gamma-ray detectors are restricted to operation over a very limited and often inconvenient temperature range. However, many important applications for radiation detectors including well logging, environmental surveillance, and gamma-ray astronomy require detectors that can provide high resolution spectroscopic measurements over a wide operating temperature range. Our research has demonstrated that highly purified and compressed xenon possesses a unique combination of properties that makes it particularly attractive as a thermally stable detection medium for high-resolution gamma-ray spectroscopy. Xenon- based detectors can exhibit energy resolutions of &lt; 2 percent at 662 keV and are relatively insensitive to temperature variations. The state of the art in high- pressure xenon detector development is discussed including detector designs, current applications, existing limitations, and suggestions for future investigations.
Production and evaluation of measuring equipment for share viscosity of polymer melts included nanofiller with injection molding machine (2016)

Shear viscosity measurement device was produced to evaluate the injection molding workability for high-performance resins. Observation was possible in shear rate from 10 to 10000 [1/sec] that were higher than rotary rheometer by measuring with a plasticization cylinder of the injection molding machine. The result of measurements extrapolated result of a measurement of the rotary rheometer.
Verification of Upcoming MCNP Features For Estimating Nuclear Data Sensitivities in Fixed Source Simulations [Abstract] (2022)

Predictive simulation codes, like the Monte Carlo N-Particle (MCNP) transport code, are used throughout the nuclear community. These simulations are based on nuclear data. Maximizing the accuracy and precision of nuclear data maximizes the accuracy and precision of the overall simulation. This is imperative to applications that rely on simulations. For example, improving nuclear data for special nuclear material improves simulation accuracy in stockpile stewardship applications, which results in larger safety margins and decreased operational costs. The improvement and validation of nuclear data is completed through integral benchmark experiments. Past benchmarks have primarily been limited to focus on the effective multiplication factor ($\kappa$<sub>eff</sub>); broadening the purview of benchmarks beyond $\kappa$<sub>eff</sub>-dependent nuclear data addresses nuclear data deficiencies. Different response types depend on different areas of nuclear data. This dependence is quantified as nuclear data sensitivity: the change in response due to perturbation of a contributing parameter. The larger the nuclear data sensitivity of a response, the more the experiment is influenced by the uncertainties of the nuclear data. The optimization of nuclear data sensitivities in future benchmarks would result in more detailed validation of lesser studied areas of nuclear data. Currently, direct sensitivity capabilities are not easily found for all experiment types and parameters. An MCNP tool to directly estimate the cross section sensitivities of tallied values is under development. Additionally, updates have been made to the perturbation feature of MCNP, which can be used in a less direct approach to estimating sensitivities. This work verifies these features to estimate nuclear data sensitivities in fixed source simulations of a 4.5-kg sphere of alpha- phase weapons-grade plutonium surrounded by differing amounts of copper and polyethylene. Integrated estimates made using MCNP’s tools were found to statistically agree with integrated estimates made from manual perturbation of nuclear data proving the validity of the MCNP tools.
Smart IoT based Energy Metering System for Microgrids with Load Management Algorithm (2018)

The number of smart meter users in this present day world is still limited. The traditional and conventional application of the smart meters was mainly to establish a bi-channel communication - one is to provide the billing details of the energy consumed via GSM modules to the end users and the other is to provide energy data and other related information that are of concern to the supplying utility. The modifications incorporated in this project are - Avoid two different channels of communication and instead concentrate the entire data into one storage system i.e. a server, that facilitates both the users and the concerned utility with access to the the real-time data from anywhere in the world and also an upgradation has been made to automatically detect and protect loads from transients in the line such as overvoltage, undervoltage and overcurrent with a load management algorithm utilizing the features of the smart energy meter IC.
N-Acetylcysteine inhibits platelet–monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial (2012)

isrctn.org ISRCTN89304265.
Flap-X: Investigations of Residual Stresses and Tumbling (2016)

Compressive residual stresses are an important influence on the fatigue life of flapper valves in compressor applications. The new material, Flap-X, has optimised residual stresses for a longer fatigue life reed valve. Residual stresses were measured using XRD for various materials before and after tumbling. Hardened strip samples of various thicknesses and steel grades were stamped to produce valve samples. Tumbling trials were performed with different durations. The edge radius and the surface roughness were measured for each thickness to understand if there was any correlation between them. Compressive residual stresses increase with an increase of tumbling time. Residual stresses before and after tumbling of various steel grades vary.
Double quantum filtered 23Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities (2018)

Double quantum filtered <sup>23</sup> Na MRI with magic angle excitation (DQF-MA) can be used to selectively detect sodium ions located within anisotropic structures such as muscle fibers. It might therefore be a promising tool to analyze the microscopic environment of sodium ions, for example in the context of osmotically neutral sodium retention. However, DQF-MA imaging is challenging due to various signal dependences, on both measurement parameters and external influences. The aim of this work was to examine how B<sub>0</sub> in combination with B<sub>1</sub> inhomogeneities alter the DQF-MA signal intensity. We showed that, in the presence of B<sub>0</sub> inhomogeneities, flip angle schemes with only one 54.7° pulse can be favorable compared with the classical 90°-54.7°-54.7° scheme. DQF-MA images of the human lower leg were acquired at B<sub>0</sub> = 3 T with a nominal spatial resolution of 12 × 12 × 36 mm<sup>3</sup> within an acquisition time of T<sub>Acq</sub> < 10 min, and compared with spin density weighted (DW), as well as triple quantum filtration (TQF) <sup>23</sup> Na images. We found mean normalized signal-to-noise ratios of TQF/DW = 13.7 ± 2.3% (tibialis anterior), 11.9 ± 2.3% (soleus) and 11.4 ± 2.2% (gastrocnemius medialis), as well as DQF-MA/DW = 4.7 ± 1.1% (tibialis anterior), 3.3 ± 0.73% (soleus) and 3.4 ± 0.6% (gastrocnemius medialis). These ratios might serve as additional measures in future clinical studies of sodium retention within human skeletal muscle. However, the influence of B<sub>0</sub> and B<sub>1</sub> inhomogeneities should be considered when interpreting DQF-MA images.
An Automated Framework for Decomposing Memory Transactions to Exploit Partial Rollback (2015)

In this paper, we present a framework that automatically decomposes programmer-written flat transactions into closed-nested transactions. The framework relies on two key mechanisms for the decomposition. The first is a static tool that analyzes application source code and produces a compact representation of transactions' business logic. The second is a run-time monitor that captures the actual contention level of shared objects and, relying on the outcome of the static tool, triggers the optimal closed-nested configuration for the workload at hand. We implemented this framework atop QR-CN, an open source fault-tolerant DTM written in Java. Our experimental studies conducted using the TPC-C, Vacation and Bank benchmarks reveal that the framework yields better performance than flat nesting and manual closed nesting, especially when the workload changes.
The kinetics of the removal of the N‐methyltrityl (Mtt) group during the synthesis of branched peptides (2002)

The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.
AN ALARMING PRESSOR REACTION TO REGITINE (1957)

Case Reports1 May 1957AN ALARMING PRESSOR REACTION TO REGITINEHENRY J. L. MARRIOTT, M.D.HENRY J. L. MARRIOTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRegitine is generally considered safe for intravenous administration. A recent review by high authorities reiterates that its administration is followed by "no hazardous pressor responses when the patient has essential hypertension."1 It seems timely therefore to report an alarming reaction recently observed.CASE REPORTThe patient was a 53 year old Negro woman whose presenting complaint was precordial pain of anginal type. Her blood pressure was found to be 290/140 mm. of Hg, without pulsus alternans. Eyegrounds showed grade 2 changes. Arterialpulsation in the neck was marked but there was no venous distention. Premature ventricular beats were frequent, and...Bibliography1. KvaleRothWangerPriestley WFGMWMJT: Pheochromocytoma, Circulation 14: 622, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication January 2, 1957.Requests for reprints should be addressed to Henry J. L. Marriott, M.D., University Hospital, Baltimore 1, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyEffect of Phentolamine and Tolazoline on Some Metabolic Processes of Heart Homogenates 1 May 1957Volume 46, Issue 5Page: 1001-1002KeywordsBlood pressureHypertensionOintmentsTachycardia ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...
A generalized cost optimal decision model for record matching (2004)

Record (or entity) matching or linkage is the process of identifying records in one or more data sources, that refer to the same real world entity or object. In record linkage, the ultimate goal of a decision model is to provide the decision maker with a tool for making decisions upon the actual matching status of a pair of records (i.e., documents, events, persons, cases, etc.). Existing models of record linkage rely on decision rules that minimize the probability of subjecting a case to clerical review, conditional on the probabilities of erroneous matches and erroneous non-matches. In practice though, (a) the value of an erroneous match is, in many applications, quite different from the value of an erroneous non-match, and (b) the cost and the probability of a misclassification, which is associated with the clerical review, is ignored in this way. In this paper, we present a decision model which is optimal, based on the cost of the record linkage operation, and general enough to accommodate multi-class or multi-decision case studies. We also present an example along with the results from applying the proposed model to large comparison spaces.
Efficient harmonic microbunching in a 7th-order inverse-free-electron laser interaction (2009)

We have shown that a seventh-order inverse-free-electron laser (IFEL) interaction, where the radiation frequency is the seventh harmonic of the fundamental resonant frequency, can microbunch a beam of relativistic electrons inside an undulator. Using coherent transition radiation (CTR) emitted by the bunched 12.3 MeV beam as a diagnostic, strong microbunching of the beam is inferred from the observation of CTR at the first, second, and third harmonics of the seed $10\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ radiation. Three-dimensional IFEL simulations show that the observed harmonic ratios can be explained only if transverse spatial distribution of the steepened bunched beam is taken into account.
Measuring a Precise Ultra-Lightweight Spaceflight Mirror on Earth: The Analysis of the SHARPI PM Mirror Figure Data during Mirror Processing at GSFC (2007)

The SHARPI (Solar High Angular Resolution Photometric Imager) primary mirror is a 5kg, 0.5m paraboloid, diffraction limited at FUV wavelengths when placed in a 0-G environment. The ULE sandwich honeycomb mirror and the attached mount pads were delivered by ITT (then Kodak) in 2003 to NASA s Goddard Space Flight Center (GSFC). At GSFC, we accepted, coated, mounted, and vibration tested this mirror in preparation for flight on the PICTURES (Planet Imaging Concept Testbed Using a Rocket Experiment) mission. At each step, the integrated analysis of interferometer data and FEA models was essential to quantify the 0-G mirror figure. This task required separating nanometer sized variations from hundreds of nanometers of gravity induced distortion. The ability to isolate such features allowed in-situ monitoring of mirror figure, diagnosis of perturbations, and remediation of process errors. In this paper, we describe the technical approach used to achieve these measurements and overcome the various difficulties maintaining UV diffraction-limited performance with this aggressively lightweighted mirror.
Synthesis, column packing and liquid chromatography of molecularly imprinted polymers for the acid black 1, acid black 210, and acid Brown 703 dyes (2022)

Molecularly imprinted polymers have been synthesized for the acid black 1, acid black 210, and acid brown 703 dyes using methacrylic acid, ethylene glycol, and azobisisobutyronitrile as the monomer, cross-linker, and initiator, respectively, in the ratio of 1 : 10 : 44 (template:monomer:cross-linker). The MIPs were used for the selective removal of their corresponding dyes. The selective nature of the MIPs towards their respective dyes was confirmed by a homemade liquid chromatography system. The resultant polymer materials were packed in a stainless steel column and checked for the separation of mixtures of dyes in liquid chromatography. The dyes complementary in structure to the imprinted cavities in the MIPs had long retention times, showing the highly selective nature of the MIPs. The pH, quantity of the MIPs, time, and concentration of the dyes were optimized for the highly efficient removal of the newly synthesized MIP adsorbents in batch adsorption studies. First-order, second-order, and intra-particle diffusion models were applied to all the three MIP-based adsorbents for their kinetic investigations towards the dyes. All the three MIPs selectively absorbed their target template molecule in the presence of four other template dyes having closely related structures with % RSD < 4% for the three batch experiments. The synthesized MIPs were characterized by FTIR, SEM imaging and liquid chromatography. FTIR results strongly confirmed the presence of hydrogen bonding interactions (600-900) between the template and the individual monomers present in the unwashed MIPs. Liquid chromatography revealed the highly selective nature of the MIPs towards their template molecules. The synthesized polymeric substances possess excellent thermal, chemical, and mechanical stability and can be reused several hundred times. The MIPs were applied in the removal of dyes from spiked water samples (river water, tap water and distilled water) where the % removal of the dyes by their corresponding MIPs was greater than 90%.
Combined Behavioral and Drug Therapy for Urge Incontinence in Older Women (2000)

This study shows that combining drug and behavioral therapy in a stepped program can produce added benefit for patients with urge incontinence.
Direct copolymerization of sulfonated poly(phthalazinone arylene ether)s for proton‐exchange‐membrane materials (2003)

Abstract Sulfonated poly(phthalazinone ether ketone) (SPPEK) copolymers and sulfonated poly(phthalazinone ether sulfone) (SPPES) copolymers containing pendant sodium sulfonate groups were prepared by direct copolymerization. The reaction of disodium 3,3′‐disulfonate‐4,4′‐difluorobenzophenone (SDFB‐Na), 4,4′‐difluorobenzophenone (DFB), and 4‐(4‐hydroxyphenyl)‐1(2 H )‐phthalazinone (DHPZ) at 170 °C in N ‐methyl‐2‐pyrrolidione containing anhydrous potassium carbonate gave SPPEKs. SPPESs were similarly obtained with 3,3′‐disulfonate‐4,4′‐difluorophenyl sulfone, 4‐fluorophenyl sulfone (DFS), and DHPZ as monomers. The sulfonic acid groups, being on deactivated positions of the polymer backbone, were expected to be hydrolytically more stable than postsulfonated polymers. Fourier transform infrared and 1 H NMR were used to characterize the structures and degrees of sulfonation of the sulfonated polymers. Membrane films of SPPEKs with SDFB‐Na/DFB molar feed ratios of up to 60/40 and SPPESs with sulfonated 4‐fluorophenyl sulfone/DFS molar feed ratios of up to 50/50 were cast from N,N ‐dimethylacetamide polymer solutions. Membrane films in acid form were then obtained by the treatment of the sodium‐form membrane films in 2 N sulfuric acid at room temperature. An increase in the number of sulfonate groups in the copolymers resulted in an increased glass‐transition temperature and enhanced membrane hydrophilicity. The sodium‐form copolymers were thermally more stable than their acid forms. The proton conductivities of the acid‐form copolymers with sulfonated monomer/unsulfonated monomer molar feed ratios of 0.5 and 0.6 were higher than 10 −2 S/cm and increased with temperature; they were less temperature‐dependent than those of the postsulfonated products. SPPESH‐50 showed higher conductivity than the corresponding postsulfonated poly(phthalazinone ether sulfone). © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 2731–2742, 2003
Fabrication of Pd Nanoparticles Embedded C@Fe3O4 Core–Shell Hybrid Nanospheres: An Efficient Catalyst for Cyanation in Aryl Halides (2015)

Isolated chemical reactors were fabricated by integrating catalytically active sites (Pd) with magnetic functionality (Fe3O4) along with carbon while preserving the constituents functional properties to realize the structure-property relationship of Pd by comparing the catalytic activity of spherical Pd NPs with cubical Pd NPs for cyanation in aryl halides using K4[Fe(CN)6] as a green cyanating agent to yield corresponding nitriles. The superior catalytic reactivity of the cubical Pd NPs is attributed to the larger number of {100} surface facets. The TEM images of reused catalyst shows the change in structure from cubical to spherical nanoparticles, attributed to the efficient leaching susceptibility of Pd {100} surface facets. The cubical Pd NPs on carbon@Fe3O4 is attractive in view of its high catalytic efficiency, easy synthesis, magnetic separability, environmental friendliness, high stability, gram scale applicability, and reusability.
Fluid Bed Coating and Granulation for CR Delivery (2010)

This chapter contains sections titled: Introduction Release Mechanism for Multiparticulate Systems Formulation Consideration Application of Fluid Bed Systems in Controlled Release Development References