gebhart/patrepeval huggingface dataset:
Abstract 6179: Comparative study of Polθ helicase and polymerase inhibitor biochemical and cellular potency (2023)

Abstract Background: DNA Polymerase θ (Polθ) is active in Theta-mediated end joining (TMEJ), a repair pathway that utilizes resected 3’ ends and micro-homology sequences to repair double strand breaks. Polθ contains an N-terminal helicase domain and a C-terminal polymerase domain. The helicase domain facilitates stripping of RPA/RAD51 from single stranded DNA and is involved in DNA-end recognition, and micro-homology search and pairing. The polymerase domain performs DNA synthesis following micro-homology pairing. Lack of Polθ is synthetic lethal in homologous recombination deficient (HRD) cells. In this study, we utilized existing small molecule inhibitors targeting either helicase or polymerase domain of Polθ, to assess their translational potential in HRD in vitro cancer cell models. Methods: Small molecules inhibiting either the helicase or polymerase activity of Polθ were studied with biochemical and cellular assays. For the biochemical studies, recombinant helicase or polymerase domains were purified. The helicase activity of Polθ was analyzed using ADP-Glo and the polymerase activity by primer extension assay. Binding assays confirmed inhibitor binding to recombinant proteins. To study inhibitor efficacy in cellular models, we probed cell viability of BRCA2-deficient cell lines. Results: Both helicase and polymerase inhibitors showed good potency in inhibiting Polθ enzymatic activity in ATPase or primer extension assays, respectively, with IC50 values in low-nanomolar range. However, the viability of BRCA2-deficient cell lines was not significantly affected after treatment with either helicase or polymerase inhibitors. The measured compound properties (stability, efflux, solubility) did not explain the lack of efficacy in cellular viability assays. Combining Polθ inhibitor treatment with ionizing radiation led to a modest enhancement of radiation-induced decrease in cell viability. Conclusions: Recently, significant advances have been made in Polθ inhibitor development prompted by the synthetic lethal interaction between Polθ and HRD discovered in several screening efforts. Both helicase and polymerase inhibitors are highly potent in biochemical assays. However, without exogenous genotoxic stress, the potential of Polθ inhibitors as therapeutic target may not be reached in vitro. Additional studies are required to understand the translational gap between biochemical and biological read-outs. Citation Format: Johanna K. Ahlskog, Antti Pohjakallio, Ralf Paul, Martin Augustin, Elisabeth Schneider, Sakshi Johri, Tuomas Tervahauta, Hans-Georg Beisel, Lars Neumann, Julia Lindqvist, Anu Moilanen. Comparative study of Polθ helicase and polymerase inhibitor biochemical and cellular potency [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6179.
Effect of Gas Sparger Type on Operational Characteristics of a Bubble Column under Mechanical Foam Control (1996)

The effects of gas sparger types on the operational characteristics of a bubble column (BC) with a rotating-disk mechanical foam-breaker (MFRD), such as foam-breaking, foaming, flow and mass transfer characteristics, were studied. The required critical disk rotational speed, Nc, and liquid hold-up in the foam, ϕL, reflected the foam-breaking behaviour of the MFRD and the foaming behaviour of the BC respectively, which changed depending on the gas sparger type. The dependence of the gas sparger type on the gas hold-up, εg, was similar to that observed for the volumetric mass transfer coefficient, kL a. A comparative investigation of kL a with various gas spargers, in terms of the specific power input, also demonstrated the usefulness of the porous sintered glass bead filter as a gas sparger.
RELATIONAL DISTANCE IN MANAGING CONFLICT (1985)

Journal Article Relational Distance in Managing Conflict Get access William A. Donohue, William A. Donohue 1William A. Donahue (Ph.D., Ohio State University, 1976) is Associate Professor of Communication at Michigan State University Search for other works by this author on: Oxford Academic Google Scholar Deborah Weider-Hatfield, Deborah Weider-Hatfield 2Deborah Weider-Hatfield (Ph.D., Purdue University, 1978) is Assistant Professor of Speech Communication at the University of Georgia Search for other works by this author on: Oxford Academic Google Scholar Mark Hamilton, Mark Hamilton 3Mark Hamilton (M.A., Michigan State University, 1983) is Assistant Professor of Communication at the University of Hawaii Search for other works by this author on: Oxford Academic Google Scholar Mary E. Diez Mary E. Diez 4Mary E. Diez (Ph.D., Michigan State University, 1983) is Assistant Professor, Department of Professional Communication at Alverno College Search for other works by this author on: Oxford Academic Google Scholar Human Communication Research, Volume 11, Issue 3, March 1985, Pages 387–405, https://doi.org/10.1111/j.1468-2958.1985.tb00053.x Published: 17 March 2006
ChemInform Abstract: STEREOSELECTIVITY IN LANTHANIDE COMPLEXES OF MALIC ACID (1980)

Abstract Spektroskopische und potentiometrische Untersuchungen zur Komplexbildung und die Berechnung der Bildungskonstanten bei pH‐Werten unter sieben werden durchgeführt.
Is quality of life affected by season and weather conditions in ankylosing spondylitis? (2001)

This study provides some support to the popular belief and frequent patient complaints of a link between health status and perceived quality of life, as assessed by a specific questionnaire, with season and weather conditions.
Dual-Resonant-Mode (DRM) Impedance Transformer and Its Application to Wideband 3 dB Power Divider (2013)

This work proposes a wideband impedance transformer through proper excitation of dual resonant modes (DRM) in a single resonator. Using an equivalent model that consists of two shunt resonant circuits in parallel, its working principle is physically explained and its wideband impedance transforming performance is achieved. Finally, a wideband 3 dB power divider is developed using this proposed transformer and the predicted results are well confirmed in experiment.
Luminescent Properties in NIR Region of LaPO<sub>4</sub>:Er/LaPO<sub>4</sub> Core/Shell Nanoparticles (2007)

To get over the drawback of nanomaterials such as quenching by O-H group for EDWA application, LaPO 4 :Er/LaO 4 core/shell nanoparticles were synthesized in the mixture solvent system and their properties were investigated through various spectroscopic techniques. The prepared core/shell nanoparticles have featured by the single phase of monazite structure and about 7-8 nm of particle size without agglomeration. In the NIR emission spectrum, the LaPO 4 /LaPO 4 core/shell nanoparticles were largely increased in NIR-PL intensity due to encapsulation of the LaPO 4 shell and the extension of lifetime were observed. In addition, the co-doping Yb 3+ as a sensitizer of emission by Er 3+ in the core/shell nanoparticles was accomplished enlargement of emission intensity at 1539 nm due to the effective energy transfer from Yb 3+ to Er 3+ . On the other hand, the longest lifetime in the prepared core/shell nanoparticles was obtained at 1% activator concentration.
Infrared absorption of trans-1-chloromethylallyl and trans-1-methylallyl radicals produced in photochemical reactions of trans-1,3-butadiene and Cℓ2 in solid para-hydrogen (2012)

The reactions of chlorine and hydrogen atoms with trans-1,3-butadiene in solid para-hydrogen (p-H(2)) were investigated with infrared (IR) absorption spectra. When a p-H(2) matrix containing Cl(2) and trans-1,3-butadiene was irradiated with ultraviolet light at 365 nm, intense lines at 650.3, 809.0, 962.2, 1240.6 cm(-1), and several weaker ones due to the trans-1-chloromethylallyl radical, ●(CH(2)CHCH)CH(2)Cl, appeared. Observed wavenumbers and relative intensities agree with the anharmonic vibrational wavenumbers and IR intensities predicted with the B3PW91/6-311++g(2d, 2p) method. That the Cl atom adds primarily to the terminal carbon atom of trans-1,3-butadiene is in agreement with the path of minimum energy predicted theoretically, but in contrast to the reaction of Cl + propene in solid p-H(2) [J. Amicangelo and Y.-P. Lee, J. Phys. Chem. Lett. 1, 2956 (2010)] in which the addition of Cl to the central C atom is favored, likely through steric effects in a p-H(2) matrix. A second set of lines, intense at 781.6, 957.9, 1433.6, 2968.8, 3023.5, 3107.3 cm(-1), were observed when the UV-irradiated Cl(2)/trans-1,3-butadiene/p-H(2) matrix was further irradiated with IR light from a SiC source. These lines are assigned to the trans-1-methylallyl radical, ●(CH(2)CHCH)CH(3), produced from reaction of 1,3-butadiene with a H atom resulted from the reaction of Cl atoms with solid p-H(2) exposed to IR radiation.
Reaction of Pyridazine and Quinoline with Silyl Enol Ethers in the Presence of Alkyl Chloroformate (1997)

Pyridazine was allowed to react with silyl enol ethers (or ketene silyl acetals) in the presence of ethyl chloroformate to give 4-and 6-substituted 1-ethoxycarbonyldihydropyridazines in good yields.The vicinal substituents of silyl enol ethers considerably affected the regioselectivity, and one of the two dihydroadducts was selectively obtained by the use of appropriate silyl enol ethers.Similar substituent effect was observed in the reaction of quinolines under the same conditions.
A transformer‐coupled double‐resonant probe for NMR imaging and spectroscopy (1987)

A new type of double-resonant coil which takes advantage of the properties of a radio-frequency transformer is described. Two concentric loops are wound in close proximity to yield a high mutual inductance. The primary side is tuned to 34 MHz for 31P and the secondary side is tuned to 85 MHz for protons. A single lead allows program control over frequency without the need to rearrange cabling. Proton and phosphorus spectroscopy are made possible over essentially the same volume of interest without the need for repositioning the sample.
Modeling of Hermetic Scroll Compressors: Model Development (2004)

This paper presents a comprehensive model for a hermetic scroll compressor. The model combines models of the compression process including leakage and local heat transfer within the scrolls, frictional losses, motor inefficiencies, and heat transfer within the shell and to the ambient. The model is useful for investigating the impact of design changes on compressor performance. Some sample results are presented in this paper. Detailed validation and an investigation of compressor design improvements are described in a companion paper.
Titanium(III) Chloride (2001)

[7705-07-9] Cl3Ti (MW 154.23) (aqueous functional group reducing agent; after reducing to low-valent species, reductive coupling reagent of carbonyls to vicinal diols and alkenes) Physical Data: mp 440 °C (dec); d 2.640 g cm−3. Solubility: sol water, alcohol; insol diethyl ether, CHCl3, CCl4, CS2, benzene. Form Supplied in: dark red–violet solid; dimethoxyethane complex, TiCl31.5DME [18557-31-8], solution in CH2Cl2/THF, solution in hydrochloric acid. Purification: sublimation of solid at 1 mmHg.1b Analysis of Reagent Purity: aqueous solutions of TiCl3 can be titrated against 0.1 N cerium(IV) sulfate.3 Handling, Storage, and Precautions: dry powder is pyrophoric in air; moisture sensitive; reacts violently with water, and causes skin burns. Heating in vacuo over ca. 450 °C gives TiCl2 and TiCl4. Use in a fume hood and in a dry box under inert atmosphere. TiCl3(DME)1.5 is air sensitive, but can be stored indefinitely under Ar at room temp. Reactions involving low-valent titanium should be run under argon.1
Survey of the State of the Art in Natural Language Generation: Core tasks, applications and evaluation (2018)

This paper surveys the current state of the art in Natural Language Generation (NLG), defined as the task of generating text or speech from non-linguistic input. A survey of NLG is timely in view of the changes that the field has undergone over the past two decades, especially in relation to new (usually data-driven) methods, as well as new applications of NLG technology. This survey therefore aims to (a) give an up-to-date synthesis of research on the core tasks in NLG and the architectures adopted in which such tasks are organised; (b) highlight a number of recent research topics that have arisen partly as a result of growing synergies between NLG and other areas of artificial intelligence; (c) draw attention to the challenges in NLG evaluation, relating them to similar challenges faced in other areas of NLP, with an emphasis on different evaluation methods and the relationships between them.
Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring (2022)

Wearable and wireless monitoring of biomarkers such as lactate in sweat can provide a deeper understanding of a subject's metabolic stressors, cardiovascular health, and physiological response to exercise. However, the state-of-the-art wearable and wireless electrochemical systems rely on active sweat released either <i>via</i> high-exertion exercise, electrical stimulation (such as iontophoresis requiring electrical power), or chemical stimulation (such as by delivering pilocarpine or carbachol inside skin), to extract sweat under low-perspiring conditions such as at rest. Here, we present a continuous sweat lactate monitoring platform combining a hydrogel for osmotic sweat extraction, with a paper microfluidic channel for facilitating sweat transport and management, a screen-printed electrochemical lactate sensor, and a custom-built wireless wearable potentiostat system. Osmosis enables zero-electrical power sweat extraction at rest, while continuous evaporation at the end of a paper channel allows long-term sensing from fresh sweat. The positioning of the lactate sensors provides near-instantaneous sensing at low sweat volume, and the custom-designed potentiostat supports continuous monitoring with ultra-low power consumption. For a proof of concept, the prototype system was evaluated for continuous measurement of sweat lactate across a range of physiological activities with changing lactate concentrations and sweat rates: for 2 h at the resting state, 1 h during medium-intensity exercise, and 30 min during high-intensity exercise. Overall, this wearable system holds the potential of providing comprehensive and long-term continuous analysis of sweat lactate trends in the human body during rest and under exercising conditions.
IBD AND RHEUMATOLOGICAL DISEASE OVERLAP IN A PREDOMINATELY AFRICAN AMERICAN CLINIC POPULATION AS COMPARED TO A NATIONAL INPATIENT DATABASE (2023)

Abstract INTRODUCTION Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are common and can involve nearly any organ. EIM can cause a significant impact on morbidity and quality of life and can be a challenge to physicians to manage IBD patients. Arthropathies occur in 6–53% of IBD patients and is considered the most common EIM. This study compares IBD- Rheumatological overlap in our university clinic with inpatients identified via the NIS database. We also evaluated the overlap in our clinic population concerning patient care. The objective of the study was to further characterize IBD-Rheumatological overlap by comparing our institution’s clinic population to patients identified via the NIS database. METHODS We used ICD-10 codes to identify IBD patients and further used a broad range of ICD-10 codes for rheumatological manifestation to identify overlapping patients in 2018 in our clinic population, the inpatient database population and NIS database. Incidence of coordinated care was determined in the clinic population. RESULTS In the clinic population there were 228 IBD patients and 2240 rheumatologic patients. Dual ICD-10 codes were found for 46 patients and further analysis resulted in 21 clinic patients with true overlap and recent visits (21/228 = 9.2%). For the inpatient analysis, there were 65,379 IBD patients with 3741 having a diagnosis for a rheumatologic disease (3741/65,379= 6%). In the clinic population, the majority of patients had diagnosed Crohn’s Disease (95.2%), were female (60%) and were African American (77%). The most common rheumatological manifestation was AS. While the inpatient data analysis also suggests that AS is more likely to be associated with Crohn’s Disease (0.64 % vs 0.43%), the most frequent manifestation was the general category of RA (3.54% vs 3.03%) In the National inpatient database, 22,552 patients had a diagnosis of UC out of which 81% were Caucasian, 10% African American, and 9% Hispanic. There were 38,962 patients with Crohn’s disease out of which 82% were Caucasian, 15.2% African American and 7% were Hispanic. The most common rheumatological manifestation was RA. DISCUSSION In the clinic population study where rheumatological disease was well characterized by experienced rheumatologists, the most frequent disease was AS and the primary IBD manifestation was Crohn’s disease. In the inpatient population, rheumatological disease in general was present in 6% of patients but it is unknown if more specific rheumatological evaluation was performed on the patients. The fact that the majority of clinic patients were seen by both GI and Rheumatology and were on effective therapies for their IBD and Rheumatological manifestations is encouraging. Both gastroenterologists and rheumatologists should be vigilant to identify the co-existence of these conditions and follow-up these patients for better outcomes.
Linear waveguides in photonic crystals based on periodic arrangement of spheres (2006)

We demonstrate the possibility of waveguiding electromagnetic waves in a monolayer of dielectric spheres. While light is confined vertically by index guiding, a triangular superlattice monolayer of spheres was found to exhibit a photonic band gap below the light cone, thereby preventing light from propagating laterally. A gap map of this structure is presented. We propose a possible waveguide configuration that yields two non-degenerate defect modes lying within the photonic band gap. Such a structure may be particularly interesting for coupling light into self-assembled colloidal photonic crystals.
Fabrication of uniform half-shell magnetic nanoparticles and microspheres with applications as magnetically modulated optical nanoprobes (2005)

Magnetically Modulated Optical Nanoprobes (MagMOONs) are magnetic particles that indicate their angular orientation by emitting varying intensities of light for different orientations and have shown promise for a variety of applications. In this letter we describe a new method to fabricate uniform magnetic half-shell particles that can be used as MagMOONs. Cobalt was deposited onto commercially made polystyrene nanospheres and microspheres, using ultrahigh vacuum vapor deposition, producing particles with uniform size, shape and magnetic content. Additionally, the coercivity of the cobalt deposited on the nanospheres was enhanced compared to its bulk value.
Catalysis in the Formation of α-Methoxymercurials from Ethylenes (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis in the Formation of α-Methoxymercurials from EthylenesA. M. Birks and George F. WrightCite this: J. Am. Chem. Soc. 1940, 62, 9, 2412–2421Publication Date (Print):September 1, 1940Publication History Published online1 May 2002Published inissue 1 September 1940https://pubs.acs.org/doi/10.1021/ja01866a043https://doi.org/10.1021/ja01866a043research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evolutionary optimization of interval mathematics-based design of a TSK fuzzy controller for anti-sway crane control (2013)

Abstract A hybrid method combining an evolutionary search strategy, interval mathematics and pole assignment-based closed-loop control synthesis is proposed to design a robust TSK fuzzy controller. The design objective is to minimize the number of linear controllers associated with rule conclusions and tune the triangular-shaped membership function parameters of a fuzzy controller to satisfy stability and desired dynamic performances in the presence of system parameter variation. The robust performance objective function is derived based on an interval Diophantine equation. Thus, the objective of a fuzzy logic-based control scheme is to place all the closed-loop control system characteristic polynomial coefficients within desired intervals. The reproduction process in the proposed Evolutionary Algorithm (EA) is based on the arithmetical crossover, uniform and non-uniform mutation along with gene deletion/insertion mutation ensuring a diversity of genomes sizes, as well as a diversity in the parameter space of membership functions. The proposed algorithm was implemented to design a fuzzy logic-based anti-sway crane control system taking into consideration the rope length and the mass of a payload variation. The results of experiments conducted using the EA for different conditions assumed for system parameter intervals and desired closed-loop system performances are compared with results achieved using the iterative procedure which is also described in the paper.
Nutritive and Bioactive Proteins in Breastmilk (2016)

Protein ingested with breast milk provides indispensable amino acids which are necessary for new protein synthesis for growth and replacement of losses via urine, feces, and the skin. Protein gain in the body of an infant is highest during the first months when protein concentrations in breast milk are higher than during later stages of lactation. Low-birth-weight infants have higher protein needs than term infants and need protein supplements during feeding with breastmilk. Based on our better understanding of protein evolution in breastmilk during the stages of lactation, new infant formulas with lower protein concentration but better protein quality have been created, successfully tested, and are now available in many countries. Besides providing indispensable amino acids, bioactive protein in breast milk can be broadly classified into 4 major functions, that is, providing protection from microbial insults and immune protection, aiding in digestive functions, gut development, and being carriers for other nutrients. Individual proteins and their proposed bioactivities are summarized in this paper in brief. Indeed, some proteins like lactoferrin and sIgA have been extensively studied for their biological functions, whereas others may require more data in support to further validate their proposed functions.