gebhart/patrepeval huggingface dataset:
Mechanical Performance Of A Two Stage Centrifugal Compressor Under Wet Gas Conditions (2011)

As subsea compression becomes a vital technology to the successful production of gas reserves in the North Sea, several technology issues will come to the forefront of the oil and gas industry.One of these important subjects is the capability to compress gas which includes a significant amount of liquids.Compressing wet gas requires knowledge in areas such as the prediction of turbomachinery performance with the mixed phase flow as well as the mechanical reliability of machinery in the same environment.This paper presents experimental results from a wet gas test campaign which, among other goals, is focused on characterizing the mechanical performance of a two stage compressor operating under wet gas conditions.Various mechanical parameters are monitored in the test program including rotor radial and axial vibration, rotor thrust, and shaft torque.A full array of wet gas conditions are tested with a suction pressure of 20 bar (300 psia) and liquid volume fractions in the range of 0.5 to 5%.The operating fluids are air and water, and the two stage compressor is operated at three speed lines ranging from high flow to low flow conditions.Significant variations are noted in the axial thrust, axial vibration and shaft torque.Thrust variations range from seemingly neutral thrust conditions at very low water injection rates to significant thrust increases (as compared to dry condition) for very high water injection rates.Rotor axial vibration is characterized by large amplitude and very low frequency, especially for the case in which the rotor thrust is balanced by the water injection.During higher levels of water injection, rotor axial vibration is generally characterized by relatively large amplitude and slightly higher frequency, although still very low as a percent of running speed.Variations in radial vibration are also noted, but to a much lesser extent.
PROLIB: code to create production library of nuclear data for design calculations. [PWR] (1977)

This PROLIB program creates, updates, and edits the production library used in the B and W nuclear design system. The production library contains the material cross section data required to perform the thermal and epithermal spectrum calculations in the NULIF program. PROLIB collapses cross section data from the master libraries, produced by the ETOGM and THOR programs, to the desired production library group structures. The physics models that are used, the calculations that are performed in PROLIB, the input, and the output are described. Information that is required to use PROLIB along with a sample problem that illustrates the input and output formats and that provides a benchmark problem are given. (auth)
Improved Detection Strategies for Nonlinear Frequency-Division Multiplexing (2018)

Two novel detection strategies for nonlinear Fourier transform-based transmission schemes are proposed. We show, through numerical simulations, that both strategies achieve a good performance improvement (up to 3 dB and 5 dB) with respect to conventional detection, respectively without or only moderately increasing the computational complexity of the receiver.
A low-power 1-GHz super-regenerative transceiver with time-shared PLL control (2001)

A low-power transceiver for ISM applications in the 868-MHz band has been integrated in a 0.8-/spl mu/m BiCMOS technology. The receiver part is based on the super-regenerative principle. The system includes two time-shared control loops, one for the selectivity and sensitivity control and one for the frequency control (PLL). The receiver with its PLL draws 3.6 mW for a sensitivity of -105 dBm and the emitter current consumption is 6 mA for a 0-dBm output power. A 2.4-V operation voltage allow the use of a two-batteries solution.
Optimal Antenna Matching and Mutual Coupling Effect of Antenna Array in MIMO Receiver (2007)

Antenna array is essential factor for multiple- input multiple-output (MIMO) wireless systems. Since the antenna array is composed of closely spaced elements, the mutual coupling among the elements cannot be ignored for the best performance of the array. Mutual coupling affects the MIMO channel, so the performance of a MIMO system, including channel capacity and diversity, varies with the degree of mutual coupling. The effect of mutual coupling is a function of the antenna load impedance. Therefore, designing an optimal element-matched array for a MIMO system requires consideration of the optimal matching condition for the array elements, the one that maximizes the channel capacity. We evaluated the effects of mutual coupling with various matching conditions in dipole arrays, and investigated their effects on the path correlation and channel capacity of MIMO systems. Simulation showed that the conventional conjugate matching of each element is still suitable for closely spaced elements except when the separation is about less than 0.1λ. Theoretical consideration of the received power of a closely-spaced-element array is also provided to show the effects of mutual coupling.
Stress-transfer characteristics in model composites (1993)

The stress-transfer characteristics in single fibre polymer-based composites have been investigated. Two distinct classes of specimen geometries were examined involving short-fibre (SFMC) as well as continuous-fibre model composites (CFMC). In all cases, the point-by-point strain in the fibre was measured through the fibre Raman spectrum and its strain dependence. The SFMCs were loaded incrementally to levels of stresses of sufficient magnitude to cause interfacial failure while the fibre strain profiles were monitored closely. The CFMCs were loaded to high enough levels to ensure fibre fracture and then the strain built up in each fragment was carefully mapped. In addition to fibre strain measurements, the interfacial shear stress distribution was derived at each increment of applied strain by means of a balance-of-forces argument. The strain-transfer profiles in the case of short aramid fibre/epoxy SFMCs indicate the presence of two regimes: a perfectly elastic case up to approximately 1.5% of applied strain is followed by interphasial yielding at the fibre ends. Clear fibre/matrix debonding in SFMCs and CFMCs occurs just prior to fibre fracture or as a result of it. Similar trends, albeit at much lower values of applied strain, were observed in the case of short high-modulus carbon fibre/epoxy composites. Current analytical stress-transfer models are reviewed in the light of the experimental data.
A Collection of Sequence Spaces (1970)

This paper concerns a collection of sequence spaces we shall refer to as ${d_\alpha }$ spaces. Suppose $\alpha = ({\alpha _1},{\alpha _2}, \ldots )$ is a bounded number sequence and ${\alpha _i} \ne 0$ for some $i$. Suppose $\mathcal {P}$ is the collection of permutations on the positive integers. Then ${d_\alpha }$ denotes the set to which the number sequence $x = ({x_1},{x_2}, \ldots )$ belongs if and only if there exists a number $k > 0$ such that \[ h_\alpha (x) = \operatorname {lub}_{p \in \mathcal {P}} \sum \limits _{i = 1}^\infty |x_{F(i)} \alpha _i| < k.\] $h_\alpha$ is a norm on $d_\alpha$ and $(d_\alpha , h_\alpha )$ is complete. We classify the ${d_\alpha }$ spaces and compare them with ${l_1}$ and $m$. Some of the ${d_\alpha }$ spaces are shown to have a semishrinking basis that is not shrinking. Further investigation of the bases in these spaces yields theorems concerning the conjugate space properties of ${d_\alpha }$. We characterize the sequences $\beta$ such that, given $\alpha ,{d_\beta }, = {d_\alpha }$. A class of manifolds in the first conjugate space of ${d_\alpha }$ is examined. We establish some properties of the collection of points in the first conjugate space of a normed linear space $S$ that attain their maximum on the unit ball in $S$. The effect of renorming ${c_0}$ and ${l_1}$ with ${h_\alpha }$ and related norms is studied in terms of the change induced on this collection of functionals.
Difference in effects of alkyl-lysophospholipids and verapamil on vincristine transport in vincristine-sensitive and -resistant human myelogenous leukemia K562. (1987)

Several kinds of alkyl-lysophospholipids enhanced the accumulation of vincristine (VCR) in both drug-sensitive and -resistant K562 cells. The drugs also augmented the efflux of VCR from the tumor cells. It is assumed that alkyl-lysophospholipids made tumor cells permeable to both the influx and efflux of VCR. The alkyl-lysophospholipids produced nonspecific effects of almost equal intensity in both sensitive and resistant tumor cells. These effects were compared with those of verapamil, a calcium channel blocker. Verapamil, as reported previously, specifically inhibited the efflux of drugs from tumor cells, especially drug-resistant tumor cells, thereby enhancing the accumulation of antitumor agents in the cells. Thus the actions of alkyl-lysophospholipids and verapamil in tumor cells were obviously different. Furthermore, the combined effects of alkyl-lysophospholipids and verapamil were additive or synergistic, indicating that their sites of action may be different.
Intracellular Pb2+ Content Monitoring Using a Protein-Based Pb2+ Indicator (2012)

Lead ion (Pb(2+)) is one of the most hazardous heavy metals to almost all life forms. The components of store-operated Ca(2+) entry as a molecular gateway have been previously found to participate in the cytotoxic entry of Pb(2+). However, the safe levels of intracellular Pb(2+) hiding in blood Pb(2+) levels are still not determined with full certainty. The present study aimed to construct protein-based Pb(2+) indicators to help establish a reliable setting for the content monitoring of intracellular Pb(2+). A series of Pb(2+) indicators based on fluorescence resonance energy transfer, Met-leads, were developed. The Pb(2+)-binding protein PbrR (from Cupriavidus metallidurans CH34) was applied between the fluorescent protein pair ECFP(ΔC11) and cp173Venus. The spectral patterns and sensing ranges of all Met-leads were characterized in vitro. Among these constructs, Met-lead 1.59 had relatively high ion selectivity and broad dynamic range (3.3-5.7). Consequently, this Met-lead was adopted in the cellular Pb(2+) biosensing. The intracellular Pb(2+) content in human embryonic kidney cells was successfully monitored using Met-lead 1.59 under both short- and long-term treatments. The existence of intracellular Pb(2+) can be significantly sensed using Met-lead 1.59 after 3 h 0.5μM (10 μg/dl) exposure, which is 200 times more improved than previous live-cell indicators. In summary, a new Pb(2+) indicator, Met-lead 1.59, was successfully developed for advanced research on Pb(2+) toxicology.
Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope (2019)

Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and "grafting" it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bicêtre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.
Traffic Aware Strategic Aircrew Requests (TASAR) (2012)

The Traffic Aware Strategic Aircrew Request (TASAR) concept offers onboard automation for the purpose of advising the pilot of traffic compatible trajectory changes that would be beneficial to the flight. A fast-time simulation study was conducted to assess the benefits of TASAR to Alaska Airlines. The simulation compares historical trajectories without TASAR to trajectories developed with TASAR and evaluated by controllers against their objectives. It was estimated that between 8,000 and 12,000 gallons of fuel and 900 to 1,300 minutes could be saved annually per aircraft. These savings were applied fleet-wide to produce an estimated annual cost savings to Alaska Airlines in excess of $5 million due to fuel, maintenance, and depreciation cost savings. Switching to a more wind-optimal trajectory was found to be the use case that generated the highest benefits out of the three TASAR use cases analyzed. Alaska TASAR requests peaked at four to eight requests per hour in high-altitude Seattle center sectors south of Seattle-Tacoma airport..
BRAF V600E and survival benefit of anti-EGFR monoclonal antibody (mAb) therapy for metastatic colorectal cancer (mCRC): A meta-analysis. (2015)

e14605 Background: BRAF V600E mutation is a known marker of poor prognosis for individuals with mCRC. However, whether it is also a predictive marker of the efficacy of anti-EGFR mAb therapy is uncertain. Methods: A systematic review and random-effects meta-analysis of RCTs was undertaken to evaluate the effect of BRAF V600E on the progression-free survival (PFS) and overall survival (OS) benefit of anti-EGFR mAb therapy for mCRC. Treatment effect was reported as a hazard ratio (HR) with 95% confidence interval (CI). Results: Six RCTs (n = 4295) met the inclusion criteria for assessment of OS, while 7 RCTs (n = 4609) met the inclusion criteria for assessment of PFS. Of the 2497 participants with RAS WT tumors across the 7 RCT substudies, 261 (10.5%) were BRAF mutant. For both OS and PFS, the HR point estimates for RAS WT / BRAF V600E tumors were situated midway between those of RAS WT / BRAF WT tumors and RAS mutant tumors. However, the reduction in efficacy (RAS WT / BRAF V600E vs RAS WT / BRAF WT) was not statistically significant (P = 0.57 and P = 0.18 for OS and PFS, respectively). For PFS, but not OS, the HR for the RAS WT / BRAF V600E tumors significantly different from RAS mutant tumors (P = 0.02). Conclusions: There is currently insufficient evidence to definitively claim that BRAF V600E is a negative predictive marker of anti-EGFR mAb benefit in RAS WT mCRC. Despite including data from 7 large RCTs comprising > 4000 participants, a larger sample size is required for adequate power to distinguish clinically meaningful differences. OS HR (95% CI), n PFS HR (95% CI), n RAS WT / BRAF WT 0.78 (0.66, 0.91), 2121 0.58 (0.48, 0.71), 2236 RAS WT / BRAF V300E 0.91 (0.56, 1.48), 246 0.76 (0.52, 1.12), 261 RAS MT 1.06 (0.93, 1.19), 1928 1.10 (0.93, 1.30), 2112
A Propose-and-revise System for Real-time Traffic Management (2000)

The aim of this paper is to describe an intelligent system for the problem of real time road traffic control. The purpose of the system is to help traffic engineers in the selection of the state of traffic control devices on real time, using data recorded by traffic detectors on motorways. The system follows an advanced knowledge-based approach that implements an abstract generic problem solving method, called propose-and-revise, which was proposed in Artificial Intelligence, within the knowledge engineering field, as a standard cognitive structure oriented to solve configuration design problems. The paper presents the knowledge model of such a system together with the strategy of inference and describes how it was applied for the case of the M-40 urban ring for the city of Madrid.
Utilization of Fractionated Bio Oil in Asphalt (2009)

Asphalt materials have been a fundamental building material in highway construction for many years including its use as a binder in hot mix asphalt (HMA) and as an emulsion in various applications including base stabilization, cold mix recycling, chip sealing and tack coats. The substantial increase in crude petroleum, from which most asphalt binder is derived, has translated into substantial increases in asphalt binders and thus asphalt material prices over the past five years. The public is most keenly aware of the increases in crude petroleum as automobile fuel prices have increased as a result too. These increases in automobile fuels have also created opportunities for refineries to further examine the addition of value added facilities in the form of cooking facilities which would remove automobile fuel components from asphalts and therefore reducing the supply of asphalt binders for use in highway construction. The near and long term impact of reduced asphalt supply to the highway construction industry is substantial and translates into critical impacts on the nation’s highways and economy as approximately 90 percent of the United States highways contain asphalt products. Substantial technological developments in the production and fractionation of bio oil, a product derived from fast pyrolysis of biomass, has the potential to be a beneficial asphalt additive/modifier/extender. Three biomass sources consisting of switch grass, corn stover and oak wood were pyrolized and fractionated in a pilot plant. The electrostatic precipitant (ESP) from the three biomass sources were blended with three different asphalt binders at 3, 6, and 9 percent by mass of the total binder and characterized. Characterization was done according to AASHTO M320 for grading a standard asphalt binder. Substantial benefits of blending the oak wood and switch grass ESP fractions with a polymer modified asphalt binder were identified.
Temporal and regional variations in sporadic Creutzfeldt–Jakob disease in Japan, 2001–2010 (2014)

The objective of this study was to examine temporal and regional variations of sporadic Creutzfeldt-Jakob disease (sCJD) in a retrospective study using Japanese national surveillance data from 2001 to 2010. We calculated the incidence of sCJD by age and sex, derived the standardized incidence in each of the 47 prefectures, and performed spatial disease clustering analysis. The average annual incidence of sCJD was 1.026 per million in men (637 patients) and 1.132 per million in women (733 patients), a significant sex difference after adjustment for age (P = 0.001). The ratios of familial CJD to sCJD apparently increased between 2001-2005 and 2006-2010, possibly as a result of the nationwide introduction of genetic testing after 2006. Based on the data of 2006-2010, certain geographical clusters of sCJD were identified. The incidence of sCJD was higher in several specific prefectures compared to the national average. Thus, sCJD appears to have regional variations, suggesting the existence of genetic or region-specific factors affecting the incidence of the disease.
Cours de chimiothérapie antitumorale et traitement médical du cancer : XXVIIe cours de l'Institut de cancérologie Gustave-Roussy Ed. 1 (2013)

Les cours de chimiotherapie et traitement medical du cancer de l'Institut Gustave-Roussy constituent un des enseignements phares de l'oncologie francophone.

	D'annee en annee, le contenu de ces cours est adapte aux nouvelles avancees des traitements medicamenteux en oncologie, et les interventions d'experts internationaux francophones permettent de presenter les bases fondamentales des traitements actuels tout en analysant le developpement des therapies moleculaires ciblees ainsi que l'emergence de strategies personnalisees basee sur l'analyse moleculaire des tumeurs. Les soins de support, qui sont indissociables des traitements specifiques aux cancers dans la prise en charge de nos patients, ont egalement toute leur place.

	Redige a partir des interventions de la 27e edition des cours, cet ouvrage propose ainsi une synthese precise et actualisee des strategies modernes en oncologie.

	Existe en version papier et eBook (tous supports).
Positively selected autologous blood CD34+ cells and unseparated peripheral blood progenitor cells mediate identical hematopoietic engraftment after high-dose VP16, ifosfamide, carboplatin, and epirubicin (1994)

To investigate the feasibility of peripheral blood CD34+ cell selection and to analyze CD34+ cell-mediated engraftment after high-dose chemotherapy, we performed a phase I/II trial in 21 patients with advanced malignancies. The rationale for the selection of CD34+ cells from peripheral blood progenitor cell (PBPC) collections is based on the observation that contaminating tumor cells can be depleted approximately 3 logs using this procedure. CD34+ cells from chemotherapy+granulocyte colony-stimulating factor-mobilized PBPCs were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). One leukapheresis product with a median number of 2.8 x 10(6) CD34+ cells/kg was labeled with a biotinylated anti-CD34 monoclonal antibody and subsequently processed over the column. The yield of selected CD34+ cells was 73% +/- 24.6%. The purity of the CD34+ cell fraction was 61.4% +/- 19.7%. CD34+ cells were shown to represent predominantly committed progenitors coexpressing CD33, CD38, and HLA-DR molecules (lin+). They gave rise to myeloid as well as erythroid and multilineage colonies in vitro. In addition, positively selected CD34+ cells also comprised early hematopoietic progenitor cells, as shown by the presence of CD34+/lin- cells. Transfusion of positively selected CD34+ cells (2.5 x 10(6) CD34+/kg; range, 0.45 to 5.1) after high-dose VP16 (1,500 mg/m2), ifosfamide (12 g/m2), carboplatin (750 mg/m2), and epirubicin (150 mg/m2) (VIC-E) in 15 patients resulted in a rapid and stable engraftment of hematopoiesis without any adverse events. As compared with 13 historical control patients reconstituted with a comparable number of unseparated PBPCs, time to neutrophil and platelet recovery was identical in both groups (absolute neutrophil count > 500/microL, day + 12; platelet count > 50,000/microL, day + 15). These data indicate that autologous peripheral blood CD34+ cells and unseparated PBPCs mediate identical reconstitution of hematopoiesis after high-dose VIC-E chemotherapy. Because positive selection of CD34+ cells from mobilized blood results in a median 403-fold depletion of T cells, allogeneic CD34+ cells from mobilized blood should be investigated as an alternative to bone marrow cells for allotransplantation.
Graft survival following three occurrences of hepatic arterial thrombosis after living-related liver transplantation. A case report. (2003)

Hepatic arterial thrombosis is a major cause of morbidity and graft loss in patients undergoing liver transplantation. We report the case of a patient who underwent living-related liver transplantation and suffered three instances of early hepatic arterial thrombosis requiring revascularization in the first 8 days after grafting. The patient was discharged with good graft function. A 21-month-old female with biliary atresia underwent living-related liver transplantation using her mother's extra-lateral segment. The donor middle hepatic artery was anastomosed end-to-end to the posterior branch of the donor's hepatic artery. The time of operation was 8 hr 36 min, and the blood loss was 193 mL. On postoperative day 5, the patient was returned to surgery to close a perforation in the transverse colon. At operation we found hepatic arterial thrombosis and performed a thrombectomy and redid the arterial anastomosis. Hepatic arterial thrombosis recurred during the operation, so we interposed the recipient's right radial artery between the graft artery and recipient posterior branch. On postoperative day 8, ultrasound showed a fluid collection in Winslow's pouch. After removing the fibrin clot, we discovered that hepatic arterial thrombosis had recurred in the interposed artery. We revascularized the graft using the right gastroepiploic artery. Arterial blood flow was restored, and graft function remained excellent.