gebhart/patrepeval huggingface dataset:
Biomechanical evaluation of hydroxyapatite intervertebral graft and anterior cervical plating in a porcine cadaveric model (1997)

The biomechanical properties of a porous hydroxyapatite (HA) intervertebral graft with or without anterior cervical plating were evaluated in cadaveric porcine cervical spine model using C3-4 discectomy and dissection of the posterior longitudinal ligament to cause instability. The experimental groups were intact (n = 11), instability (n = 11), autogenous bone implant (n = 6), HA graft implant (n = 5), autogenous bone with plating (n = 6), and HA graft with plating (n = 5). Porous HA with 40% porosity and scapular bone were used as grafts. The displacement rates of the cervical spine by compressive forces in the flexural, extensional, and lateral bending directions were evaluated using video-recording followed by computer-assisted analysis. The stiffness to compressive load was calculated from the load-displacement rate curve. The linear and non-linear coefficients of the Fung's equation were obtained based on the plot of Young's modulus against load. There were no statistical differences in the stiffness between the HA and autogenous bone graft in all directions. The two plating groups showed significantly increased stiffness in all directions. The non-linear coefficient value in Fung's equation was far larger in both HA and HA graft with plating groups than in the other groups in flexural compression. Porous HA graft has a compressive strength similar to autogenous graft in vitro, and anterior plating provides additional stiffness to the cervical spine. The larger non-linear coefficient value of the HA groups may represent the characteristic biomechanical brittleness of HA graft, but this is manifest only in flexural compression.
Heterozygous recurrent HNF4A variant p.Arg85Trp causes Fanconi renotubular syndrome 4 with maturity onset diabetes of the young, an autosomal dominant phenocopy of Fanconi Bickel syndrome with colobomas (2020)

Heterozygous pathogenic variants in HNF4A cause hyperinsulinism, maturity onset diabetes of the young type 1, and more rarely Fanconi renotubular syndrome. Specifically, the recurrent missense pathogenic variant c.253C>T (p.Arg85Trp) has been associated with a syndromic form of hyperinsulinism with additional features of macrosomia, renal tubular nephropathy, hypophosphatemic rickets, and liver involvement. We present an affected mother, who had been previously diagnosed clinically with the autosomal recessive Fanconi Bickel Syndrome, and her affected son. The son's presentation expands the clinical phenotype to include multiple congenital anomalies, including penile chordee with hypospadias and coloboma. This specific pathogenic variant should be considered in the differential diagnosis of Fanconi Bickel Syndrome when genetics are negative or the family history is suggestive of autosomal dominant inheritance. The inclusion of hyperinsulinism and maturity onset of the diabetes of the young changes the management of this syndrome and the recurrence risk is distinct. Additionally, this family also emphasizes the importance of genetic confirmation of clinical diagnoses, especially in adults who grew up in the premolecular era that are now coming to childbearing age. Finally, the expansion of the phenotype to include multiple congenital anomalies suggests that the full spectrum of HNF4A is likely unknown.
User Guide for the CESSDA Metadata Model (2019)

This document includes guidelines for the usage of and best practice for the CESSDA Metadata Model (https://doi.org/10.5281/zenodo.3236171). The guidelines address all relevant aspects of the elements in the CESSDA Metadata Model, and serve to provide recommendations and guidance for usage. Please note that this document is the first public version of the User Guide for the CESSDA Metadata Model and thus considered as a final draft, meaning that comments and requests for revision by the CESSDA community are welcome. Please send your requests to the CESSDA Metadata Office via metadata-office@cessda.eu.
Classification of single molecular motor events (2004)

Abstrucf-This paper describes the development of two methods for automatic classification of molecular events. The methods are applied to experimental results obtained to study the interaction of a single microtubule with a single Ncd molecular motor. The data were previously obtained using optical trap assay, and have a very low signal-to-noise ratio of approximately 0.1. The first method can be viewed as a syntactic classification. In an alternative approach. radial basis neural networks, trained with simulated data generated by a system of stochastic, Langevin-like differential equations, are used for classification. Following classification. the molecular events are ensemble averaged separately for different types of events. The analysis of the results suggests the existence of Ncd-microtubule interaction events, which deviate from the traditional view on the kinetics of the Ncd-microtubule interactions. Tnis paper employs a novel paradigm, which emphasizes the importance of the modelbased, time-resolved filtering of the experimental data on molecular interactions, especially for the case of biological molecules, followed by the analysis of different goups of events, automatically segregated according to features revealed during the single realization analysis of the experimental results.
High-Efficient Portable Welding Machine Based on Full-Bridge Converter with ISOP-Connected Single Transformer and Active Snubber (2016)

This paper suggests a high-efficiency portable welding machine based on full-bridge converter with input-series-output-parallel (ISOP)-connected single transformer. Link voltage balance problem is theoretically analyzed according to deviations of transformer leakage inductances and transformer turns-ratios and simple voltage-balancing circuit using flying capacitor is introduced to remove this problem. Also, active-snubbing method is also proposed to improve overall efficiency by recovering parasitic resonant energy and regulating the voltage stress of rectifiers to the level that Schottky diodes are available. The feasibility of the proposed structure has been verified with 17.5-kW welding machine with 60-kHz switching frequency.
From History to Mystery: The Parliamentary Inquiries into the Kidnapping and Murder of Aldo Moro, 1979–2001 (2007)

On March 16, 1978, Aldo Moro was kidnapped by the Red Brigades, who held him captive in a "people's prison" in Via Montalcino for fifty-four days and murdered him on May 9. Three decades later, this apparently straightforward description of the tragedy had become remarkably controversial. Many key details were now disputed: who had planned and participated in the kidnapping, where Moro had been held captive, whether anyone apart from the kidnappers had had contact with him, whether any of the possibly compromising documents he might have written in the "people's prison" had been removed and destroyed, who had made the final decision to murder rather than release him. Radical doubts were not voiced only by irreducible conspiracy theorists. In 1998 the Italian President, Scalfaro, declared his belief that the real organizers of the kidnapping had yet to be identified, and in 1999 Moro's son Giovanni claimed that two decades of investigation had served only to reinforce the view that the truth lay further away than ever.1 For events pored over by police, judges and lawyers, politicians, academics, and journalists for a quarter of a century—during which most of the protagonists have retired or died; their political parties, along with the Red Brigades themselves, have vanished; and the awareness of the event among younger Italians has become minimal—the escalation rather than abatement of controversy about even the facts of his fate seems deeply paradoxical.
A boundary element approach to the scattering from inhomogeneous dielectric bodies (1998)

A boundary element method (BEM) for the analysis of the electromagnetic scattering from inhomogeneous dielectric structures is presented. The problem is formulated in terms of a single integral equation reducing by half the number of unknowns required with respect to a conventional approach based on two coupled integral equations.
Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp+) Is an Essential Regulator of T-Lymphocyte Ca2+-Signaling (2000)

Microinjection of human Jurkat T-lymphocytes with nicotinic acid adenine dinucleotide phosphate (NAADP(+)) dose-dependently stimulated intracellular Ca(2+)-signaling. At a concentration of 10 nM NAADP(+) evoked repetitive and long-lasting Ca(2+)-oscillations of low amplitude, whereas at 50 and 100 nM, a rapid and high initial Ca(2+)-peak followed by trains of smaller Ca(2+)-oscillations was observed. Higher concentrations of NAADP(+) (1 and 10 microM) gradually reduced the initial Ca(2+)-peak, and a complete self-inactivation of Ca(2+)-signals was seen at 100 microM. The effect of NAADP(+) was specific as it was not observed with nicotinamide adenine dinucleotide phosphate. Both inositol 1,4, 5-trisphosphate- and cyclic adenosine diphosphoribose-mediated Ca(2+)-signaling were efficiently inhibited by coinjection of a self-inactivating concentration of NAADP(+). Most importantly, microinjection of a self-inactivating concentration of NAADP(+) completely abolished subsequent stimulation of Ca(2+)-signaling via the T cell receptor/CD3 complex, indicating that a functional NAADP(+) Ca(2+)-release system is essential for T-lymphocyte Ca(2+)-signaling.
Data from Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background&lt;/b&gt;: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use of molecular biomarkers may enhance the sensitivity of cytologic examination in the detection of lung cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods&lt;/b&gt;: Complement factor H, a protein secreted by lung cancer cells, was quantified in a series of bronchoalveolar lavage supernatants from lung cancer patients and patients with nonmalignant respiratory diseases. Albumin, total protein content, and hemoglobin were also analyzed. Results were validated in independent sets of bronchoalveolar lavage and sputum supernatants.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results&lt;/b&gt;: There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. The sensitivity and specificity of the factor H test was 82% and 77%, respectively. These results were validated in an independent set of patients with nearly identical results. Furthermore, 70% and 45% of bronchoalveolar lavage fluids from central and peripheral tumors, respectively, reported as cytologically negative, were classified as positive using this marker. Finally, the test was evaluated in a series of sputum supernatants from lung cancer patients and controls. The sensitivity and specificity of the factor H test in this series was 80% and 88%, respectively.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion&lt;/b&gt;: Factor H is elevated in bronchoalveolar lavage and sputum from lung cancer patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact&lt;/b&gt;: Measurement of molecular biomarkers, such as complement factor H, may be used in the future as an adjunct to cytology in the diagnosis of malignant pulmonary diseases. Cancer Epidemiol Biomarkers Prev; 19(10); 2665–72. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Microwave Assisted Synthesis of 2,4,6-Triarylamino-1,3,5-triazines as Potential UV Absorbent (2003)

Abstract 2,4,6-Triarylamino-1,3,5-triazines was synthesized in a few minutes by reaction of cyanuric chloride with aromatic amines under microwave irradiation. This method is featured with rapid reaction, convenient operation, high yield, and clean. UV-absorption was tested for each compound. Keywords: Microwave2,4,6-Triarylamino-1,3,5-triazineUV-absorbent
Channel feedback reduction for wireless multimedia broadcast multicast service systems (2015)

With the increasing demand of wireless multimedia services, the multimedia broadcast multicast service (MBMS) is an emerging technology which is adopted in new wireless communication standards to enhance multimedia data transmission. In an MBMS system, all the users subscribing to the service receive multimedia data via the broadcast channel from the base station (BS). To ensure the quality of the broadcast, the MBMS users feedback their channel state information (CSI) to the BS. The BS then selects the best transmission mode according to the users' feedbacks to achieve the optimal result. This CSI feedback operation results in increasing feedback load with the number of users and hence reduces the spectrum efficiency. In this paper, a novel method is proposed to reduce the feedback load of the MBMS systems. The proposed method let the users determine individually whether feeding back their CSI will be critical for the BS to select the transmission mode. If not, a user does not feedback. Different decision rules at the users incur different degrees of MBMS rate loss, which is mathematically analyzed. Through simulations, we show that the proposed method can significantly reduce the CSI feedback load with only a slight impact on the MBMS rate.
Release of leukotrienes during rapid expulsion of Trichinella spiralis from immune rats. (1987)

Rapid expulsion of the nematode Trichinella spiralis from immune rats is associated with an increase in volume of intestinal exudate and the presence of large numbers of tissue mucosal mast cells (MMC) and eosinophils. We have measured the concentrations of leukotrienes (LT) C4 (LTC4) and B4 (LTB4) in gut perfusates and mucosal homogenates at 30 min, 1, 3, 6 and 20 hr after challenge with larvae. Leukotrienes were identified by radioimmunoassay (RIA) combined with reverse-phase high-pressure liquid chromatography (RP-HPLC). There were significant elevations at 30 min and 1 hr in the concentrations of LTC4 in the perfusates from the gut of challenged immune rats compared to controls (infected unchallenged and uninfected naive rats). Similar increases in immunoreactive LTC4 and LTB4 were observed in mucosal homogenates from the gut of immune challenged animals. A second peak of LTB4 was also observed at 20 hr in both immune and naive challenged rats. There were also elevations in serum concentration of the MMC-associated specific serine protease, rat mast cell protease II (RMCPII). Since LTC4 causes smooth muscle contraction, increased vascular permeability and stimulation of mucus hypersecretion, and LTB4 recruits and activates inflammatory cells, leukotrienes may participate in the process of rapid expulsion of T. spiralis.
A pharmacokinetic study of erythromycin in man (1980)

SummaryA study was carried out to investigate the pharmacokinetic parameters of erythromycin lactobionate and erythromycin ethylsuccinate in patients with acute exacerbation of chronic bronchitis. Erythromycin concentrations in serum and sputum were determined after 1 g oral doses of the ethylsuccinate and after a 500 mg intravenous injection of the lactobionate. Models of the doses and regimens were simulated from the data. The results demonstrated the fast diffusion of erythromycin lactobionate in the peripheral compartment. Plasma and bronchial secretion concentrations of the two products were particularly high, especially in the case of the lactobionate which, therefore, is indicated in the most severe infections.
Rab proteins as major determinants of the Golgi complex structure (2017)

GTP-ases of the Rab family (about 70 in human) are key regulators of intracellular transport and membrane trafficking in eukaryotic cells. Remarkably, almost one third associate with membranes of the Golgi complex and TGN (trans-Golgi network). Through interactions with a variety of effectors that include molecular motors, tethering complexes, scaffolding proteins and lipid kinases, they play an important role in maintaining Golgi architecture.
Secure enhanced wireless transfer protocol (2006)

When IEEE 802.11i draft proposed TKIP, it is expected to improve WEP on both active and passive attack methods. TKIP uses more sophisticated methods to distribute and manage secret keys and also requires software upgrade only instead of changing hardware equipment. However, implementing TKIP on the exiting equipment, the transmission performance is decreased dramatically. This paper, therefore, proposes a new transfer scheme to enhance previous WEP and TKIP protocols - secure enhanced wireless transfer protocol (SEWTP). SEWTP provides an encryption algorithm on top of current hardware that improves low performance in TKIP but without compromising security level in the mean time. This is achieved by encrypting secret key twice. Secret key are stored at both access point (AP) and wireless client so that it can be compared and validated.
43.1: A Simple Vision Model for Inhomogeneous Image‐Quality Assessment (1998)

Abstract The single filter model for image quality assessment previously presented at this meeting breaks down when the image luminance or masking contrast energy varies spatially within the image. A slightly more complex version of the single filter model is presented which allows for these inhomogeneities.
Chloroplast DNA codes for transfer RNA (1976)

Transfer RNA's were isolated from Euglena gracilis. Chloroplast cistrons for tRNA were quantitated by hybridizing tRNA to ct DNA. Species of tRNA hybridizing to ct DNA were partially purified by hybridization-chromatography. The tRNA's hybridizing to ct DNA and nuclear DNA appear to be different. Total cellular tRNA was hybridized to ct DNA to an equivalent of approximately 25 cistrons. The total cellular tRNA was also separated into 2 fractions by chromatography on dihydroxyboryl substituted amino ethyl cellulose. Fraction I hybridized to both nuclear and ct DNA. Hybridizations to ct DNA indicated approximately 18 cistrons. Fraction II-tRNA hybridized only to ct DNA, saturating at a level of approximately 7 cistrons. The tRNA from isolated chloroplasts hybridized to both chloroplast and nuclear DNA. The level of hybridization to ct DNA indicated approximately 18 cistrons. Fraction II-type tRNA could not be detected in the isolated chloroplasts.
B09 Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HDHQ150 knock-in mouse model of Huntington's disease (2012)

Huntington9s disease (HD) is a late-onset progressive neurodegenerative disorder characterised by irrepressible motor dysfunction, cognitive decline and psychiatric disturbances for which there is no effective disease-modifying treatment. The proteolytic cleavage of huntingtin (HTT) to generate N-terminal fragments has been proposed to be a key aspect of HD pathogenesis. In particular, it has been shown that HTT can be cleaved at amino acid 586 by caspase-6 (CASP6) and that prevention of cleavage at this site is neuroprotective and can rescue HD-related phenotypes in YAC transgenic HD mouse models. To further explore the role that CASP6 plays in HTT proteolysis, we have evaluated the effects of the genetic ablation of CASP6 in the HdhQ150 knock-in mouse model of HD. Here we show that the loss of CASP6 has no effect on the proteolysis of HTT, and does not modify the pattern of N-terminal HTT fragments that are present in the brains of these animals. Furthermore, we show that CASP6 ablation does not influence the steady-state levels of soluble wild type or mutant HTT in the brains of presymptomatic mice. Therefore, we conclude that CASP6 inhibition does not modify HTT proteolysis in the HdhQ150 mouse model of HD, and that targeting CASP6 as a therapeutic strategy should be approached with caution in the context of this complex disease.
The Use of Computed Tomography Numbers in Dose Calculations for Radiation Therapy (1985)

Although corrections for 'beam hardening' and 'scattering' have been implemented in currently available CT scanners, systematic differences exist between a real CT image and an ideal, artefact-free and monochromatic image. The appearance and magnitude of these differences are discussed. Conversion to the ideal image, i.e. conversion from CT number to X-ray attenuation coefficient at diagnostic photon energies, turns out to be possible with an accuracy of 5 per cent. In order to use the CT 'density' information from patients, in clinical photon and electron beam dose calculations, conversions must be made from the X-ray attenuation coefficient at diagnostic energies to relevant high energy radiation interaction properties. These conversions turn out to be possible within an accuracy also of 5 per cent. These limited accuracies cause errors in the photon beam dose calculation of less than 1 per cent of the dose maximum and errors in electron beam dose calculations of less than 2 per cent of the dose maximum.
Studies of Synergism/Antagonism for Lowering Interfacial Tensions in Alkyl Benzene Sulfonate Mixtures (2009)

Synergistic effect for lowering interfacial tension in alkyl benzene sulfonates mixtures-alkane systems was studied by spinning drop tensiometer. The results show that surfactant mixtures of similar structure tend to give the same γmin for the same nmin, while the alkane preference curve of the surfactant mixtures with different structures take on the shape of that of surfactant with higher interfacial activity. In the case of surfactant mixtures with different interfacial activities, the one with lower activity will modify the hydrophilic-lipophilic balance of surfactant with higher activity and result in synergism/antagonism.
In Vitro Evaluation of Antimicrobial Activity of Alimentary Canal Extracts from the Red Palm Weevil,Rhynchophorus ferrugineusOlivier Larvae (2017)

The invasive red palm weevil, <i>Rhynchophorus ferrugineus</i> Olivier (Coleoptera: Curculionidae), is considered one of the world's most devastating insect pests to palm trees. It was observed that larvae of this pest are able to inhibit microbial growth on the rearing media when they start feeding and this observation has led us to study the effect of red palm weevils on various microbial species. The antimicrobial effect of extracts from different parts of the alimentary canal on Gram positive bacteria (<i>Enterococcus faecalis</i> and <i>Staphylococcus aureus</i>), Gram negative bacteria (<i>Escherichia coli</i> and <i>Klebsiella</i> spp.), <i>Candida albicans,</i> and <i>Penicillium</i> sp. was tested using the agar well diffusion method. All extracts inhibited the tested microbial species. Foregut extracts had the greatest zones of growth inhibition. <i>Enterococcus faecalis</i>, <i>Staphylococcus aureus,</i> and <i>Penicillium</i> sp. were significantly sensitive to the extracts and had the largest growth inhibition zones. It is concluded that the gut extracts contain potent antimicrobial activity and may provide a new source of antimicrobial peptides.