PD59-06 INFLAMMATORY-BOWEL-DISEASE IS ASSOCIATED TUMOR-INFILTRATING CD8 AND CD20 LYMPHOCYTES IN PROSTATE CANCER (2020)

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (PD59)1 Apr 2020PD59-06 INFLAMMATORY-BOWEL-DISEASE IS ASSOCIATED TUMOR-INFILTRATING CD8 AND CD20 LYMPHOCYTES IN PROSTATE CANCER Anuj Desai*, Jason Cohen, Ketan Jain-Poster, Michael H. Shin, Lauren Cooley, Minh Pham, Conor Driscoll, Adam Weiner, Amanda Vo, Oliver Ko, Sarki A Abdulkadir, Jenny Ross, Tamara L Lotan, Jennifer D. Wu, and Shilajit Kundu Anuj Desai*Anuj Desai* More articles by this author , Jason CohenJason Cohen More articles by this author , Ketan Jain-PosterKetan Jain-Poster More articles by this author , Michael H. ShinMichael H. Shin More articles by this author , Lauren CooleyLauren Cooley More articles by this author , Minh PhamMinh Pham More articles by this author , Conor DriscollConor Driscoll More articles by this author , Adam WeinerAdam Weiner More articles by this author , Amanda VoAmanda Vo More articles by this author , Oliver KoOliver Ko More articles by this author , Sarki A AbdulkadirSarki A Abdulkadir More articles by this author , Jenny RossJenny Ross More articles by this author , Tamara L LotanTamara L Lotan More articles by this author , Jennifer D. WuJennifer D. Wu More articles by this author , and Shilajit KunduShilajit Kundu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000969.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Recent data has implicated inflammatory bowel disease (IBD) as a risk factor for clinically-significant prostate cancer (PC). One key driver of IBD-associated malignant transformation could be systemic chronic inflammation or immunomodulation from immunosuppressive medications. However, how IBD may influence the local tissue microenvironment of the prostate and induce prostate tumorigenesis is unknown. Our objective is to determine whether prostate cancer tissue in men with IBD has differences in the inflammatory infiltrate and associated downstream signaling cascade compared to those without IBD. METHODS: We obtained radical prostatectomy specimens on 10 patients with IBD and 22 controls at our institution. Clinical parameters were obtained by chart review. Immunohistochemical (IHC) analysis was performed for inflammatory markers (CD4, CD8, CD20 lymphocytes) and androgen receptor (AR). Stained sections were reviewed and scored by a blinded independent genitourinary pathologist for the site-specific (benign glands, tumor infiltrating, stroma, and peri-prostatic regions) positivity of each IHC marker. Multivariable linear regression adjusting for age, race, prostate-specific-antigen (PSA) level, and pathologic gleason grade was performed to determine the relationship between IBD and each IHC marker. RESULTS: There was no significant difference in median age [61 (53-71) vs. 63 (53-73) yrs, p=0.65], the proportion of black patients [1/10 (10%) vs. 5/22 (23%), p=0.71], and PSA level [5.4 (2.3-9.4) vs. 5.8 (1.4-15.4), ng/mL, p=0.67] between IBD and non-IBD patients in our cohort. Positivity of inflammatory markers and AR was not different in benign glands, stroma, and peri-prostatic regions (p>0.05). However, IBD was associated with tumor infiltrating CD20 [OR 1.57 (1.15-2.14), p = 0.009] and CD8 [OR 1.61(1.71-2.21) p= 0.008] lymphocytes. CONCLUSIONS: PC in men with IBD has a unique tumor microenvironment and is enriched with tumor-infiltrating CD8 and CD20 lymphocytes. These findings may suggest that high numbers of intratumoral lymphocytes suppress anti-tumor activity, thereby promoting tumor development in men with IBD. However, further investigation is needed to determine the mechanistic and prognostic significance of these findings. Source of Funding: SPORE in Prostate Cancer © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1207-e1207 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anuj Desai* More articles by this author Jason Cohen More articles by this author Ketan Jain-Poster More articles by this author Michael H. Shin More articles by this author Lauren Cooley More articles by this author Minh Pham More articles by this author Conor Driscoll More articles by this author Adam Weiner More articles by this author Amanda Vo More articles by this author Oliver Ko More articles by this author Sarki A Abdulkadir More articles by this author Jenny Ross More articles by this author Tamara L Lotan More articles by this author Jennifer D. Wu More articles by this author Shilajit Kundu More articles by this author Expand All Advertisement PDF downloadLoading ...