gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Chemistry of Some 1‐(α‐Fluoroalkyl)benzotriazoles. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lessons Learned From One Hundred Right Lobe Living Donor Liver Transplants (2004)

There is a learning curve in adult right lobe LDLT. The results have significantly improved with technical refinement and better experience.
Frequency-Domain Residual Interference Cancellation in Cyclic Prefix Assisted Single-carrier Communications (2006)

Cyclic Prefix (CP) has been applied in the single-carrier systems to resist the inter-block interference (IBI) due to the frequency selective fading channel and equalize the channel by one-tap frequency domain equalizer. However, there still exists the residual inter-symbol interference (ISI) due to imperfect channel equalization, which will severely degrade the system performance. In this paper the residual ISI is analysis in CP-SC with linear minimum mean square error (LMMSE) equalizer. With the initial estimates of LMMSE equalizer, the interference cancellation (IC) technique is adopted to alleviate the residual ISI so that the system performance can be considerably improved.
Synthesis and Structure Solution of Zeolite SSZ-65 (2007)

This report describes the synthesis and structure solution of the new zeolite SSZ-65. SSZ-65 may be prepared as either a borosilicate (Si52.5B1.5O108) or an aluminosilicate using 1-[1-(4-chloro-phenyl)-cyclopropylmethyl]-1-ethyl-pyrrolidinium as a structure-directing agent. The structure of SSZ-65 was determined with the FOCUS Fourier recycling method. The framework of SSZ-65 possesses a two-dimensional system of intersecting 12-ring channels with pore apertures of 6.9 Å × 5.9 Å. The topological symmetry of SSZ-65 is P6/mmm, but improvements in the Rietveld refinement of the powder diffraction data are obtained in space group P6/m (a = 16.8009(2) Å and c = 12.6154(1) Å). The agreement values improve from Rwp = 0.116, Rp = 0.094, and R(F2) = 0.142 in P6/mmm to Rwp = 0.103, Rp = 0.085, and R(F2) = 0.092 in P6/m.
Automatic determination of parameters for multipad functional electrical stimulation: Application to hand opening and closing (2012)

Transcutaneous functional electrical stimulation (FES) is a method used for rehabilitation of patients having suffered a stroke or spinal cord injury. When applying FES a common problem is that stimulation electrodes have to be placed with great care in order to avoid activation of muscles close to the target muscles. A promising approach to circumvent this problem is to employ multipad FES, i.e. to employ electrode arrays containing many small electrodes allowing selective activation of muscles. In this work an algorithm is presented which automatically determines subsets of active electrodes and stimulation currents such that movements with user-specified amplitudes are induced. Using a recently developed portable multipad FES system and a virtual reality dataglove, the algorithm was tested with seven able-bodied subjects. Stimulation with parameters determined by the algorithm led to movements with a median deviation of between 0° and 5° from the specified wrist angle and between 0% and 12% from the specified degree of finger flexion.
Interventional Closure of a Large Pseudoaneurysm of the Ascending Aorta in a Patient after Lung Transplantation (2019)

•Pseudoaneurysm is a rare but life-threatening complication after thoracic surgery.•Standard therapy is surgical occlusion and excision of the aneurysm.•Interventional closure with ASD occluder is an alternative for patients deemed inoperable.
Measurement of $|V_{cb}|$ with $B_s^0 \to D_s^{(*)-} μ^+ ν_μ$ decays (2020)

The element |Vcb| of the Cabibbo-Kobayashi-Maskawa matrix is measured using semileptonic Bs0 decays produced in proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb-1. Rates of Bs0→Ds-μ+νμ and Bs0→Ds∗-μ+νμ decays are analyzed using hadronic form-factor parametrizations derived either by Caprini, Lellouch and Neubert (CLN) or by Boyd, Grinstein and Lebed (BGL). The measured values of |Vcb| are (41.4±0.6±0.9±1.2)×10-3 and (42.3±0.8±0.9±1.2)×10-3 in the CLN and BGL parametrization, respectively. The first uncertainty is statistical, the second systematic, and the third is due to the external inputs used in the measurement. These results are in agreement with those obtained from decays of B+ and B0 mesons. They are the first determinations of |Vcb| at a hadron-collider experiment and the first using Bs0 meson decays. © 2020 CERN. © 2020 CERN, for the LHCb Collaboration. Funded by SCOAP3
Excess Avalanche Noise in $\hbox{In}_{0.52}\hbox{Al}_{0.48}\hbox{As}$ (2007)

Avalanche multiplication and excess noise arising from both electron and hole injection have been measured on a series of In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.52</sub> Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.48</sub> As p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -i-n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> and n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -i-p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> diodes with nominal avalanche region widths between 0.1 and 2.5 mum. With pure electron injection, low excess noise was measured at values corresponding to effective k=beta/alpha between 0.15 and 0.25 for all widths. Enabled ionization coefficients were deduced using a non-local ionization model utilizing recurrence equation techniques covering an electric field range from approximately 200 kV/cm to 1 MV/cm
Improving the photovoltaic performance of ladder-type dithienonaphthalene-containing copolymers through structural isomerization (2014)

The photovoltaic device based on copolymer <bold>PaDTNBTO</bold> shows an efficiency of 6.44% with a <italic>V</italic><sub>oc</sub> of 0.92 V.
Greatly attenuated reactivity of nitrile-derived carbon-centered radicals toward oxygen (2002)

Several cyanoalkyl radicals are reported to be unreactive toward oxygen; spin delocalization on nitrogen is proposed to be the most important factor to explain this unusual behaviour.
Role of group A Streptococcus HtrA in the maturation of SpeB protease (2007)

The serine protease high-temperature requirement A (HtrA) (DegP) of the human pathogen Streptococcus pyogenes (group A Streptococcus; GAS) is localized to the ExPortal secretory microdomain and is reportedly essential for the maturation of cysteine protease streptococcal pyrogenic exotoxin B (SpeB). Here, we utilize HSC5 (M5 serotype) and the in-frame isogenic mutant HSC5DeltahtrA to determine whether HtrA contributes to the maturation of other GAS virulence determinants. Mutanolysin cell wall extracts and secreted proteins were arrayed by 2-DE and identified by MALDI-TOF PMF analysis. HSC5DeltahtrA had elevated levels of cell wall-associated M protein, whilst the supernatant had higher concentrations of M protein fragments and a reduced amount of mature SpeB protease, compared to wild-type (WT). Western blot analysis and protease assays revealed a delay in the maturation of SpeB in the HSC5DeltahtrA supernatant. HtrA was unable to directly process SpeB zymogen (proSpeB) to the active form in vitro. We therefore conclude that HtrA plays an indirect role in the maturation of cysteine protease SpeB.
Fast, compact and label-free electrical detection of live and dead single cells (2013)

Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.
Dielectric properties of polymer‐derived ceramic reinforced with boron nitride nanotubes (2020)

Abstract The electrical and dielectric properties of boron nitride nanotubes (BNNTs) reinforced ceramic composites using the polymer‐derived ceramic (PDC) processing route were investigated in this work. The electrical resistivity of the pristine PDC increases from 10 6 to 10 8 Ω m after the addition of BNNTs. When the BNNT loading was increased to 5 wt%, the average real relative permittivity of the PDC decreased from 2.94 to 2.80, while the quality factor ( Q ) of the PDC increased from 134.40 to 176.77. The BNNTs can increase the Q factor of the PDC due to the reduction in the porosity cause by the introduction of the BNNTs. Further increasing the BNNT content decreases the real relative permittivity of the nanocomposites and increases the Q factor at high frequency. The average real relative permittivity decreases to 2.29, while the average Q factor increases to 208.60 when the BNNT content is increased to 30 wt%. The dielectric loss after the addition of high fraction of BNNTs can be explained by the Lorentz resonance relaxation process. Results of this work showed that PDC‐BNNT nanocomposites are satisfactory electromagnetic transparent materials when the BNNT fraction is less than 10 wt%.
Analysis of aggregate size as a process variable affecting paclitaxel accumulation in Taxus suspension cultures (2011)

Plant cell aggregates have long been implicated in affecting cellular metabolism in suspension culture, yet the rigorous characterization of aggregate size as a process variable and its effect on bioprocess performance has not been demonstrated. Aggregate fractionation and analysis of biomass-associated product is commonly used to assess the effect of aggregation, but we establish that this method is flawed under certain conditions and does not necessarily agree with comprehensive studies of total culture performance. Leveraging recent advances to routinely measure aggregate size distributions, we developed a simple method to manipulate aggregate size and evaluate its effect on the culture as a whole, and found that Taxus suspension cultures with smaller aggregates produced significantly more paclitaxel than cultures with larger aggregates in two cell lines over a range of aggregate sizes, and where biomass accumulation was equivalent before elicitation with methyl jasmonate. Taxus cuspidata (T. cuspidata) P93AF cultures with mean aggregate sizes of 690 and 1,100 μm produced 22 and 11 mg/L paclitaxel, respectively, a twofold increase for smaller aggregates, and T. cuspidata P991 cultures with mean aggregate sizes of 400 and 840 μm produced 6 and 0.3 mg/L paclitaxel, respectively, an increase of 20-fold for smaller aggregates. These results demonstrate the importance of validating experiments aimed at a specific phenomenon with total process studies, and provide a basis for treating aggregate size as a targeted process variable for rational control strategies.
Adaptive Blind SIMO Identification: Derivation of an Optimal Step Size for the Unconstrained Multichannel LMS Algorithm (2006)

Adaptive algorithms for blindly identifying SIMO systems are appealing because of their computational efficiency and capability of continuously tracking a time-varying system. Adaptive multichannel LMS (MCLMS) algorithms (with and without the unit-norm constraint) are analyzed and the optimal step size is derived. A simple yet effective variable step-size unconstrained MCLMS algorithm is proposed and its performance is evaluated with simulations.
Fukutin-related protein mutations that cause congenital muscular dystrophy result in ER-retention of the mutant protein in cultured cells (2004)

Mutations in the gene encoding fukutin-related protein (FKRP) cause a spectrum of diseases including congenital muscular dystrophy type 1C (MDC1C), limb girdle muscular dystrophy 2I (LGMD2I) and congenital muscular dystrophies (CMDs) with brain malformations and mental retardation. Although these diseases are associated with abnormal dystroglycan processing, the cellular consequences of the idiosyncratic FKRP mutations have not been determined. Here we show, in cultured cells, that FKRP mutants associated with the more severe disease phenotypes (S221R, A455D, P448L) are retained in the endoplasmic reticulum (ER), whereas the wild-type protein and the mutant L276I that causes LGMD2I are found predominantly in the Golgi apparatus. The ER-retained proteins have a shorter half-life than the wild-type FKRP and are preferentially degraded by the proteasome. Furthermore, calnexin binds preferentially to the ER-retained mutants suggesting that it may participate in the quality control pathway for FKRP. These data provide the first evidence that the ER-retention of mutant FKRP may play a role in the pathogenesis of CMD and potentially explain why the allelic disorder LGMD2I is milder, because the mutated protein is able to reach the Golgi apparatus.
Thermodynamic properties of hydrogen-bonded dimers B⋯HF from spectroscopy: B = HCN, CH3CN, HC2CN, (CH3)3CCN and H2O (1991)

The rotational and vibrational spectra of several hydrogen-bonded dimers B⋯HF have now been investigated in sufficient detail to allow the thermodynamic properties of B⋯HF to be evaluated with useful accuracy. Dissociation energies D0 for dimers B⋯HF are known from the measurement of absolute intensities of rotational transitions in equilibrium gas mixtures of B, H and B⋯HF. Together with vibrational separations and rotational constants, the D0 have been used to estimate ΔHm(T) for the reaction B + HF = B⋯HF where B = HCN, CH3CN, HC2CN, (CH3)3CCN and H2O. The standard spectroscopic entropies S(T, M) have been evaluated for each participant M in the reaction and thence ΔSm(T), ΔGm(T) and Km(T). Finally, standard functions for each B⋯HF at 298.15 K are tabulated.
Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors (2017)

Discovery of the exceptionally powerful anticancer drug dolastatin 10 (1), contained in the sea hare Dolabella auricularia, opened a new frontier needed for improving human cancer treatment. Subsequently, major advances have been achieved based on results of structurally modifying this unusual natural peptide while maintaining the remarkable anticancer activity necessary for preparation of successful monoclonal antibody drug conjugates (ADC). Among the first several hundred SAR products based on dolastatin 10 our group synthesized and termed auristatins was auristatin E (2a). An anticancer activity-equivalent, desmethylaurisatin E (2b), linked to a CD30 monoclonal antibody is the very successful anticancer drug Adcetris, now approved for use in 65 countries. In the present investigation, we discovered a new subset of auristatins designated quinstatins derived from dolastatin 10 by replacing the C-terminal Doe unit with a carefully designed quinoline, which led to low or subnanomolar levels of cancer cell growth inhibition required for construction of chemically unique ADC drugs. The synthesis of quinstatins 2-8 is presented along with their cancer cell line biological data.
Data based modelling of driveability for internal combustion engines (2018)

Non-convex hull concepts are used to describe shapes or images in data processing. The most widely used non-convex hull methods were introduced to visualize two- or three-dimensional data obtained via 3D scans or GPS signals. Data hulls have also been used as feasibility models in automotive control systems. For these higher-dimensional problems the computational complexity bears an important factor for data processing software. Commonly used methods, such as the convex hull, involve triangulations, which are numerically intractable in practice for dimensions above 10. Simple, spatial models can be computed and evaluated fast, using and floating point operations, respectively, but they perform poorly as feasibility classifiers if the data is close to infeasible regions. This article introduces a class of conic hulls that can be calculated for any input dimension with sub-quadratic, and evaluated with sub-linear, CPU complexity, respectively. These hulls are designed to include screening information of the measurement procedures embedded in the data generating processes.
Hydrogen and carbon-13 NMR spectral studies on dicyclopentadiene complexes of rhodium(I) containing N-heterocycles (1990)

The bridge cleavage reaction of [Rh(μ-​Cl)​(DCPD)​]​2 (DCPD = endo-​dicyclopentadiene) with exo-​bidentate N-​heterocycles (N-​N) yields binuclear complexes [{RhCl(DCPD)​}​2(μ-​N-​N)​] [N-​N = pyrazine (pyz)​, 4,​4'-​bipyridyl (bpy)​, trans-​1,​2-​bis(4-​pyridyl)​ethylene (bpel)​]​. The 1H NMR spectral assignments of DCPD and [Rh(μ-​Cl)​(DCPD)​]​2 have been unequivocally confirmed by two-​dimensional NMR spectroscopy. The stereochem. aspects of the latter are reflected in selective homonuclear 1H{1H} nuclear Overhauser enhancement studies. The N-​N bridged structure for the complexes [{RhCl(CDPD)​}​2(μ-​N-​N)​] has been proposed based on the recurrence of spectral features of their precursor in addn. to those of the uncoordinated N-​heterocycles. The synergistic effect in the metal-​olefin bonding in these complexes in manifested in the upfield shifts of olefinic proton and carbon resonances as compared with those of free DCPD. The complexes, [{RhCl(DCPD)​}​2(μ-​N-​N)​] undergo facile substitution of DCPD with CO to afford carbonyl complexes retaining the [Rh(μ-​N-​N)​Rh] unit.
New Recombinant Phytase from Kosakoniasacchari: Characteristics and Biotechnological Potential (2020)

A DNA sequence from Kosakonia sacchari that, according to automated computer analysis, is believed to correspond to the gene for histidine-acid phytase has been selected from the GenBank database. The sequence was optimized for codon composition, synthesized, cloned, and expressed in Pichia pastoris. The main characteristics of the purified recombinant enzyme were determined. It was established that a pH of 4.5 and a temperature of 50°C are optimal for phytase functioning. The specific activity, Michaelis constant (Km), and maximum reaction rate (Vmax) with phytate as a substrate were 1470 U/mg, 193 μM and 2167 μmol/(min mg), respectively. It was shown that the enzyme was characterized by a wide range of working pH levels. Therefore, due to its properties, this new recombinant phytase can be considered a high-potential enzyme for agrobiotechnology.
Very low protein diet plus ketoacid analogs of essential amino acids supplement to retard chronic kidney disease progression (2018)

VLPD supplementation with KA/EAA is associated with delayed renal progression while preserving the nutritional status in the patients with CKD. Co-administration of VLPD and KA/EAA may prove an effective alternative to conservative management of CKD.
Experimental mummification—In the tracks of the ancient Egyptians (2020)

Understanding natural and artificial postmortem alterations in different tissues of the human body is essential for bioarchaeology, paleogenetics, physical anthropology, forensic medicine, and many related disciplines. With this study, we tried to gain a better understanding of tissue alterations associated with the artificial mummification techniques of ancient Egypt, in particular for mummified visceral organs. We used several entire porcine organs and organ sections (liver, lung, stomach, ileum, and colon), which provided a close approximation to human organs. First, we dehydrated the specimens in artificial natron, before applying natural ointments, according to the ancient literary sources and recent publications. We periodically monitored the temperature, pH value, and weight of the specimens, in addition to radiodensity and volumetric measurements by clinical computed tomography and sampling for histological, bacteriological, and molecular analyses. After seven weeks, mummification was seen completed in all specimens. We observed a considerable loss of weight and volume, as well as similar courses in the decay of tissue architecture but varying levels of DNA degradation. Bacteriologically we did not detect any of the initially identified taxa in the samples by the end of the mummification process, nor any fungi. This feasibility study established an experimental protocol for future experiments modeling ancient Egyptian mummification of visceral organs using human specimens. Understanding desiccation and mummification processes in non-pathological tissues of specific visceral organs may help to identify and interpret disease-specific alterations in mummified tissues in ancient Egyptian canopic jars and organ packages contained in whole mummies.
A theory of allelic and isotypic exclusion for immunoglobulin genes. (1982)

Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the "H chain toxicity" effect.
An Ectopic Study of Apatite-Coated Silk Fibroin Scaffolds Seeded with AdBMP-2-Modified Canine bMSCs (2011)

The present study was undertaken to evaluate ectopic new bone formation effects of apatite-coated silk fibroin scaffolds (mSS) seeded with adenovirus-mediated bone morphogenic protein-2 gene (AdBMP-2) transduced canine bone marrow stromal cells (bMSCs) in nude mice. In this study, bMSCs derived from canine were cultured and transduced with AdBMP-2 adenovirus-mediated enhanced green fluorescent protein gene (AdEGFP) in vitro. Osteogenic differentiation of bMSCs was determined by alkaline phosphatase (ALP) activity analysis, and the transcript levels for BMP-2, osteopontin (OPN), osteocalcin (OCN) and bone sialoprotein (BSP) genes via real-time quantitative PCR (RT-qPCR) analysis. The ectopic bone formation effects of mSS seeded with AdBMP-2-modified bMSCs were evaluated through histological and histomorphological analysis 4, 8 and 12 weeks post-operation in nude mice. ALP activity was statistically increased in the AdBMP-2 group, when compared with control groups. The mRNA expression of BMP-2, OPN, OCN and BSP was also statistically up-regulated 6 and 9 days after AdBMP-2 transduction. Significantly higher bone volume was achieved in AdBMP-2-transduced bMSCs/mSS constructs than that of AdEGFP-transduced bMSCs/mSS or bMSCs/mSS groups at 4, 8 and 12 weeks (P < 0.01). These results demonstrated that mSS seeded with AdBMP-2-transduced canine bMSCs can promote ectopic new bone formation and maturation in nude mice, suggesting the potential of this silk-scaffold-based tissue-engineered bone for further bone regeneration studies in canine models.