gebhart/patrepeval huggingface dataset:
Doping of adsorbed graphene from defects and impurities in SiO2substrates (2012)

The performance of novel graphene-based devices often strongly depends on the electrical quality of the supporting oxide. To elucidate the general governing principles underlying this behavior, we use first-principles simulations to generate representative classes of experimentally known defect centers in passivated silicon dioxide substrates and study their charge transfer with adsorbed graphene. We find that many of the open-shell structural perturbations generated near the interface self-passivate during annealing, leading to occupied-unoccupied pairs of midgap states in the silicon dioxide band structure, but no doping of the graphene occurs. However, dangling bonds or paramagnetic defect centers stable to thermal annealing do lead to partially occupied midgap energy states that are energetically misaligned with the Dirac point of graphene allowing charge to flow to or from the carbon layer. In particular, dangling oxygen bonds in the oxide strongly $p$ dope the graphene. We also study doping from charge donating impurities within the substrate lattice as these also act to limit the performance of graphene-based devices.
Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats (2018)

A risk of ischemic stroke increases exponentially after menopause. Even a mild-ischemic stroke can result in increased frailty. Frailty is a state of increased vulnerability to adverse outcomes, which subsequently increases risk of cerebrovascular events and severe cognitive decline, particularly after menopause. Several interventions to reduce frailty and subsequent risk of stroke and cognitive decline have been proposed in laboratory animals and patients. One of them is whole body vibration (WBV). WBV improves cerebral function and cognitive ability that deteriorates with increased frailty. The goal of the current study is to test the efficacy of WBV in reducing post-ischemic stroke frailty and brain damage in reproductively senescent female rats. Reproductively senescent Sprague-Dawley female rats were exposed to transient middle cerebral artery occlusion (tMCAO) and were randomly assigned to either WBV or no-WBV groups. Animals placed in the WBV group underwent 30 days of WBV (40 Hz) treatment performed twice daily for 15 min each session, 5 days each week. The motor functions of animals belonging to both groups were tested intermittently and at the end of the treatment period. Brains were then harvested for inflammatory markers and histopathological analysis. The results demonstrate a significant reduction in inflammatory markers and infarct volume with significant increases in brain-derived neurotrophic factor and improvement in functional activity after tMCAO in middle-aged female rats that were treated with WBV as compared to the no-WBV group. Our results may facilitate a faster translation of the WBV intervention for improved outcome after stroke, particularly among frail women.
Degradation Kinetics of Wheat Straw Mixed with Different Proportions of Berseem (1999)

Dried and ground samples of wheat straw, mixed with either. O (I), 15 (II), 30 (III) or 45 (IV) percent berseem, were incubated In nylon bags Inside the rumen of flstulated cattle, fed on wheat straw and berseem in similar proportions. The bags were incubated for 6, 11, 24, 48, 72 and 96 h. For wheat straw ‘a’ was 5.86, 5.96.6.14 and 5.53; ‘b’ was 4054, 43.35, 44.84 and 43.46, ‘c’ was 1.70, 1.99, 2.19 and 1.86; and Lag time (LT) was 2.10, 1.69, 1.38 and 2.03 h in animals fed on diets I, II, III, and IV, respectively. Berseem supplementation significantly (P< 0.05) reduced the lag period, however, it had no effect on water soluble fraction. Potential degradable fraction increased (P<0.01) with increasing levels of berseem upto 30 percent in the diet beyond which there was no further improvement. For the DM of mixed substrate in I, II, III and IV ‘a’ was 5.64, 8.65, 12.12 and 15.98, *b’ was 41.66, 45.66, 52.59 and 43.87, ‘c’ was 1.61, 2.16, 2.61 and 2.54; LT was2.48, 2.02, 1.15 and 1.10 h, respectively. With increased proportion of berseem In the substrate there was a significant (P<0.01) increase in ‘a’ fraction, however, ‘b’ and ‘c’ fractions (P<0.01) increased only upto 30 percent, beyond which it was reduced; LT reduced (P<0.05) with increasing proportion of berseem in the substrate. It is concluded that berseem supplementation upto 30 percent to wheat straw increased the rate and extent of degradation of DM by reducing the lag time and also by increasing the potential degradabllity of wheat straw component.
Dual function of clock component OsLHY sets critical day length for photoperiodic flowering in rice (2021)

Circadian clock, an endogenous time-setting mechanism, allows plants to adapt to unstable photoperiod conditions and induces flowering with proper timing. In Arabidopsis, the central clock oscillator was formed by a series of interlocked transcriptional feedback loops, but little is known in rice so far. By MutMap technique, we identified the candidate gene OsLHY from a later flowering mutant lem1 and further confirmed it through genetic complementation, RNA interference knockdown, and CRISPR/Cas9-knockout. Global transcriptome profiling and expression analyses revealed that OsLHY might be a vital circadian rhythm component. Interestingly, oslhy flowered later under ≥12 h day length but headed earlier under ≤11 h day length. qRT-PCR results exhibited that OsLHY might function through OsGI-Hd1 pathway. Subsequent one-hybrid assays in yeast, DNA affinity purification qPCR, and electrophoretic mobility shift assays confirmed OsLHY could directly bind to the CBS element in OsGI promoter. Moreover, the critical day length (CDL) for function reversal of OsLHY in oslhy (11-12 h) was prolonged in the double mutant oslhy osgi (about 13.5 h), indicating that the CDL set by OsLHY was OsGI dependent. Additionally, the dual function of OsLHY entirely relied on Hd1, as the double mutant oslhy hd1 showed the same heading date with hd1 under about 11.5, 13.5, and 14 h day lengths. Together, OsLHY could fine-tune the CDL by directly regulating OsGI, and Hd1 acts as the final effector of CDL downstream of OsLHY. Our study illustrates a new regulatory mechanism between the circadian clock and photoperiodic flowering.
Selective Inhibition of Spinal Cord Neurite Outgrowth and Cell Survival by the Eph Family Ligand Ephrin-A5 (1999)

The Eph family tyrosine kinase receptors and their ligands, the ephrins, have been shown to play critical roles in cell migration, tissue morphogenesis, and axonal guidance in many different systems. However, their function in the spinal cord has not been examined carefully. We showed in this study that several Eph receptors, including EphA3, Eph A4, and Eph A5, are expressed in the ventral spinal cord in partially overlapping patterns, with EphA5 exhibiting the most widespread transcription in the entire ventral spinal cord during early development. Complementary to the receptor expression, a ligand of these receptors, ephrin-A5, is transcribed in the dorsal half of the spinal cord. Consistent with the spatial location of receptor expression, the ligand selectively inhibits neurite outgrowth and induces cell death of the ventral, but not the dorsal, spinal cord neurons. These observations suggest that interactions between the Eph family receptors and ligands exerts negative influences on ventral spinal cord neurons and thus may play important roles in regulating morphogenesis and axon guidance in the spinal cord.
Insights into the different exploits of colour in the visual cortex (1994)

A new method that allows controlled masking of luminance contrast has been developed to study the use of chromatic signals in human vision. The method also makes it possible to examine the different uses of chromatic signals (e.g. the generation of perceived colour, or the construction and representation of object structure and form). By using this technique, we studied the threshold detection of chromatic signals in normal trichromats. The results show that chromatic signals are virtually unaffected by ongoing, randomly varying, luminance contrast changes. These findings suggest that chromatic signals are either processed independently or can be separated completely from any confounding luminance contrast components in the stimulus. Thresholds for detection of colour changes only, and for extraction of stimulus structure from chromatic signals in normal trichromats, in subjects with single cone receptor deficiency (i.e. dichromats) and in three subjects with abnormal colour vision caused by bilateral damage to ventromedial, extra-striate visual cortex (i.e. subjects with cerebral achromatopsia) have also been measured. No significant difference in thresholds for the two conditions was observed either in normal trichromats or in dichromats. Subjects with cerebral achromatopsia, however, reveal markedly different thresholds. The results suggest that chromatic signals are processed independently to generate perceived object colour or to construct spatially structured objects, and that these functions involve different neural substrates. The results help to explain, at least in part, why cerebral achromatopsia is a heterogeneous disorder, and why there can be significant differences in the effective use of chromatic signals in subjects described as cerebral achromatopsics.
Extracting remote photoplethysmogram signal from endoscopy videos for vessel and capillary density recognition (2016)

In this paper, we propose a new feature for finding lesions in gastrointestinal tissues. Polyps or cancerous parts have different capillary pattern compared with normal parts. There are polyps which have higher density of vessel or capillary pattern. This feature leads us to extract remote photoplethysmogram signal from different parts of videos from gastrointestinal tissue. Due to the fact that hemoglobin absorbs more light than surrounding tissues, more changes are expected to be observed in the parts with higher density of vessels and capillaries. In the experimental results, rPPG signals is extracted from colonoscopy and endoscopy videos. This feature is used to distinguish between normal and abnormal tissues. It is shown that power of rPPG signal can be used to find lesion areas.
30. Postpartum care (2016)

MANAGEMENT Treatment of IAI Initiation of antibiotics at the time of diagnosis is the standard of care for treatment of IAI (Table 22.3). This recommendation is supported by several studies demonstrating decreased maternal and fetal morbidity with administration of intrapartum antibiotics. These studies most consistently have shown decreased rates of neonatal bacteremia and sepsis, and also decreased rates of maternal febrile morbidity and length of postpartum stay [8,25,31,32]. These data are exclusively from cohort studies; there have been no RCTs to date comparing antibiotics to no treatment or placebo for women with IAI [33].
Effects of a Luteinizing Hormone-Releasing Hormone Analog and Tamoxifen on the Growth of an Estrogen-Induced Prolactin-Secreting Rat Pituitary Tumor and Its Influence on Pituitary Gonadotropins* (1981)

The effect of a potent LHRH analog (ICI 118,630) on the growth of the estrogen-induced transplantable PRL-secreting rat pituitary tumor 7315a was compared with the effect of the antiestrogen tamoxifen. Implantation of this PRL-secreting tumor induced hyperprolactinemia, and plasma FSH and LH levels were suppressed. The total PRL content of the pituitary gland was decreased, but the glands of tumor-bearing animals contained 50–100% more FSH and LH than nontumor-bearing controls. Plasma 17β-estradiol concentrations and ovarian weight were not changed, but uterine weight decreased after tumor implantation. The administration of the LHRH analog (5 or 25 μg, sc, twice daily for 12 days) inhibited pituitary tumor growth by 68 ± 11% and 71 ± 8%, respectively (P < 0.01 and P < 0.01, respectively). This was accompanied by a decrease in plasma 17β-estradiol and the ovarian and uterine weights. The total FSH and LH contents of the pituitary glands of the LHRH-treated tumor-bearing rats were diminished in the presence of elevated circulating levels of FSH and LH 90 min after the last administration of the LHRH analog. A further dose-dependent inhibition of the total PRL content of the host's pituitary gland was observed after LHRH. The administration of tamoxifen (200 μg/kg- day) sc for 12 days inhibited tumor growth by 74 ± 6% (P < 0.01). After this treatment, plasma 17β-estradiol, ovarian and uterine weights, plasma FSH and LH, and the total pituitary content of PRL, FSH, and LH were not different from those in rats with control tumors. It is suggested that tamoxifen and the LHRH analog inhibit tumor growth in the model of the estrogen-induced transplantable rat pituitary tumor in different ways. Tamoxifen exerts its effects through a blockade of the estrogen receptors on the tumor, while LHRH induces a chemical castration despite a stimulating effect oh pituitary FSH and LH secretion. The strong tumor growth-inhibiting effect of this LHRH analog could have a practical application in the treatment of metastatic breast cancer and gonadal tumors in man. (Endocrinology108: 1878, 1981)
Structure of Porcine Secretin (1970)

Porcine secretin is a heptacosapeptide with the amino acid sequence His‐Ser‐Asp‐Gly‐Thr‐Phe‐Thr‐Ser‐Glu‐Leu‐Ser‐Arg‐Leu‐Arg‐Asp‐Ser‐Ala‐Arg‐Leu‐Gln‐Arg‐Leu‐Leu‐Gln‐Gly‐Leu‐ValNH 2 . Fourteen of its twenty‐seven amino acids occur in the same position as they do in porcine glucagon.
Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status (2023)

We have shown that ageing leads to a significant decrease in DHT concentration that is accompanied by impaired arterial wall characteristics and worsened endothelial function. Therefore more attention should be paid to the DHT, DHEA-S and ADG concentrations as a biomarkers for vascular dysfunction in ageing men.
Synthesis of Poly(sulfonium cation) by Oxidative Polymerization of Aryl Alkyl Sulfides (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Poly(sulfonium cation) by Oxidative Polymerization of Aryl Alkyl SulfidesKimihisa Yamamoto, Eiichi Shouji, Fumiaki Suzuki, Shintaro Kobayashi, and Eishun TsuchidaCite this: J. Org. Chem. 1995, 60, 2, 452–453Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/jo00107a027https://doi.org/10.1021/jo00107a027research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: SYNTHESIS AND OPTICAL RESOLUTION OF SUBSTITUTED DIBENZO(B,F)(1,4)DIAZOCINES (1979)

Abstract Ausgehend von dem Phthalimid (I) und den Aromaten (II) werden nach angegebener Reaktionsfolge die Diaroyl‐benzole (VII) synthetisiert und mit o‐Phenylendiamin (VIII) zu den Dibenzodiazocinen (i)‐(IX) (dreidimensionale Struktur) cyclokondensiert.
Different Approximation Techniques For A FOPID Feedback Control of a DC Motor (2022)

DC motors are commonly employed in many industrial applications due to their various advantages. This study aims to compare the response of the Oustaloup-Recursive-Approximation (ORA) and El-Khazali’s approximation method in controlling a DC motor with a FOPID controller. The two employed methods are used to design the FOPID and approximate. For various fractional orders, many behaviours are presented. A simulation comparison between these methods is performed regarding overshoot, settling time and rise time.
Cancer Drug Development in the Modern Era (2004)

Abstract For several decades the development of anticancer therapeutics has focused largely on the identification of compounds capable of interfering with the process of cell division. The completed human genome sequence, the use of comprehensive genetic studies in lower organisms, and the robust definition of signaling, death, motility, metabolic, hypoxia, DNA repair, stress response, and other pathways have enabled and are reinvigorating both the selection of rational targets and the application of small‐molecule drug design to the problem of cancer therapeutic development.
Chemical Reactivity of PF[sub 5] and LiPF[sub 6] in Ethylene Carbonate/Dimethyl Carbonate Solutions (2001)

The thermal decomposition of in a mixture (1:1 molar ratio) of ethylene carbonate (EC)/dimethyl carbonate (DMC) at 85°C is compared to the reaction between EC/DMC and gas. Both produce a brown solution and gaseous products. The reaction products from and in 1:1 EC/DMC, detected by gas chromatography, are similar. Proton nuclear magnetic resonance provided evidence for the presence of oligoether carbonates in the reaction products. © 2001 The Electrochemical Society. All rights reserved.
Characteristics of interelectrode flashover in air with the existence of a weakly ionized plasma channel induced by a KrF laser (248 nm) (1986)

The irradiation of a KrF laser (248 nm) into the interelectrode space affects the electric flashover characteristics there. The results obtained show that negative oxygen ions dominate formation of the interelectrode arc in air. A laser beam is introduced parallel to the interelectrode axis and the equipment is arranged to prevent the occurrence of photoelectric effects on the electrode surfaces. The time separation between laser firing and application of the interelectrode voltage is varied from 10 ns to 10 ms. The interelectrode spacing is set in the range 2–12 cm. The arc formation time and the flashover probability are measured. The initial ion number density is estimated experimentally to be on the order of 1011 cm−3 throughout the channel.
Smart manufacturing (2017)

Manufacturing has evolved and become more automated, computerised and complex. In this paper, the origin, current status and the future developments in manufacturing are disused. Smart manufacturing is an emerging form of production integrating manufacturing assets of today and tomorrow with sensors, computing platforms, communication technology, control, simulation, data intensive modelling and predictive engineering. It utilises the concepts of cyber-physical systems spearheaded by the internet of things, cloud computing, service-oriented computing, artificial intelligence and data science. Once implemented, these concepts and technologies would make smart manufacturing the hallmark of the next industrial revolution. The essence of smart manufacturing is captured in six pillars, manufacturing technology and processes, materials, data, predictive engineering, sustainability and resource sharing and networking. Material handling and supply chains have been an integral part of manufacturing. The anticipated developments in material handling and transportation and their integration with manufacturing driven by sustainability, shared services and service quality and are outlined. The future trends in smart manufacturing are captured in ten conjectures ranging from manufacturing digitisation and material-product-process phenomenon to enterprise dichotomy and standardisation.
Magnetic resonance of polyaspartic acid-coated magnetite nanoparticles administered in mice (2005)

Magnetic resonance (MR) was used in the biodistribution investigation of magnetic nanoparticles (MNPs) surface-coated with polyaspartic acid (PAMF), developed as a biocompatible magnetic fluid (BMF) sample. The data allowed us to obtain the kinetic parameters for MNP disposition from the blood and its uptake by the liver, spleen, and lungs. Light microscopy confirmed the MR results. Genetic and toxicity tests showed that the PAMF is reasonable biocompatible. The PAMF sample presented peculiar biodistribution patterns and may be considered as a potential precursor of anticancer drugs.
Mechanical Behavior of Ti6Al4V Scaffolds Filled with CaSiO3 for Implant Applications (2019)

Triply periodic minimal surfaces (TPMS) are becoming increasingly attractive due to their biomedical applications and ease of production using additive manufacturing techniques. In the present paper, the architecture of porous scaffolds was utilized to seek for the optimized cellular structure subjected to compression loading. The deformation and stress distribution of five lightweight scaffolds, namely: Rectangular, primitive, lattice, gyroid and honeycomb Ti6Al4V structures were studied. Comparison of finite element simulations and experimental compressive test results was performed to illustrate the failure mechanism of these scaffolds. The experimental compressive results corroborate reasonably with the finite element analyses. Results of this study can be used for bone implants, biomaterial scaffolds and antibacterial applications, produced from the Ti6Al4V scaffold built by a selective laser melting (SLM) method. In addition, Ti6Al4V manufactured metallic lattice was filled by wollastonite (CaSiO3) through spark plasma sintering (SPS) to illustrate the method for the production of a metallic-ceramic composite suitable for bone tissue engineering.
Linking applicatory functions to the 3-position of pyrrole by click chemistry (2012)

A straight forward and reliable method was developed to tether recognition functions to a side chain in position 3 of pyrroles via triazole linkage.The products are precursors for functionalized polypyrroles, e. g. for coating magnetic nanoparticles or selective electrodes.A pyrrole with an azido function located at the terminus of a side chain in position 3 was submitted to coppercatalyzed Meldal-Sharpless click reaction with alkynes bearing biotin, nitrilotriacetic acid or a RGD-containing cyclopentapeptide.The latter presents a very versatile building block for the introduction of the RGD-moiety in a variety of potential substrates.
Regulated Antisense Transcription Controls Expression of Cell-Type-Specific Genes in Yeast (2011)

Transcriptome profiling studies have recently uncovered a large number of noncoding RNA transcripts (ncRNAs) in eukaryotic organisms, and there is growing interest in their role in the cell. For example, in haploid Saccharomyces cerevisiae cells, the expression of an overlapping antisense ncRNA, referred to here as RME2 (Regulator of Meiosis 2), prevents IME4 expression. In diploid cells, the a1-α2 complex represses the transcription of RME2, allowing IME4 to be induced during meiosis. In this study we show that antisense transcription across the IME4 promoter region does not block transcription factors from binding and is not required for repression. Mutational analyses found that sequences within the IME4 open reading frame (ORF) are required for the repression mediated by RME2 transcription. These results support a model where transcription of RME2 blocks the elongation of the full-length IME4 transcript but not its initiation. We have found that another antisense transcript, called RME3, represses ZIP2 in a cell-type-specific manner. These results suggest that regulated antisense transcription may be a widespread mechanism for the control of gene expression and may account for the roles of some of the previously uncharacterized ncRNAs in yeast.