gebhart/patrepeval huggingface dataset:
A Study on Hierarchical Overlay Multicast Architecture in Mobile Ad Hoc Networks (2006)

오버레이 네트워크는 하부계층의 네트워크에 변화가 있어도 응용계층의 트리에는 변화를 줄 필요가 없으며, 오버레이 네트워크가 멀티캐스트를 지원하지 않는 노드들이 존재하는 환경에서도 만들어질 수 있게 해준다. 오버레이 프로토콜은 동적인 그룹을 모니터링하는 반면, 하부계층의 유니캐스트 프로토콜은 동적인 네트워크를 책임짐으로써, 동적인 환경에서도 제어 오버헤드를 줄이고, 프로토콜의 오퍼레이션을 안정적으로 만든다. 그러나, 만약 오버레이 멀티캐스트 프로토콜이 구성원의 위치정보를 모른다면, 효율적인 멀티캐스트 트리를 만드는 것은 매우 어렵다. 그래서, 위치정보를 이용한 계층적 오버레이 멀티캐스트 구조(HOMA: Hierarchical Overlay Multicast Architecture)를 본 논문에서 제안한다. 제안된 구조는 멀티캐스트에 참여하는 호스트들만으로 정적인 지역을 기반으로 동적 그룹을 만들어서 상위 계층에서는 그룹을 대표하는 호스트들 간의 오버레이 멀티캐스트 망을 형성하근 하위 계층에서는 지역에 속한 멀티캐스트 호스트들 간의 멀티캐스트를 지원하는 응용 계층의 2-계층 오버레이 멀티캐스트이다. 이것은 GPS를 사용하고, 지리적 영역을 활용하며 노드의 이동에 크게 영향을 받지 않는 지역 기반의 상위 계층의 오버레이 멀티캐스트 트리를 보여준다. 시뮬레이션 결과는 멀티캐스트의 효율성의 문제를 효과적으로 해결하였음을 보여준다. Overlay network eliminates the need to change the application-layer tree when the underlying network changes and enables the overlay network to survive in environments where nonmember nodes do not support multicast functionality. An overlay protocol monitors group dynamics, while underlying unicast protocols track network dynamics, resulting in more stable protocol operation and low control overhead even in a highly dynamic environment. But, if overlay multicast protocols does not know the location information of node, this makes it very difficult to build an efficient multicasting tree. So, we propose a Hierarchical Overlay Multicast Architecture (HOMA) with the location information. Because proposed architecture makes static region-based dynamic group by multicast members, it is 2-tired overlay multicasts of application layer that higher layer forms overlay multicast network between members that represent group, and support multicast between multicast members belonging to region at lower layer. This use GPS, take advantage of geographical region, and realizes a region-sensitive higher layer overlay multicast tree which is impervious to the movements of nodes. The simulation results show that our approach solves the efficiency problem effectively.
New strategies for bacterial contaminations (2016)

Background The detection of bacterial contaminations in blood components can be classified in culture methods, rapid detection methods and experimental new technologies. Culture methods Culture methods have shown their benefit through easy handling and high analytic sensitivity. The challenge with culture methods, with the negative‐to‐date release concept, is a risk for false negative screening results due to sample failures and a reduced clinical efficiency. Rapid detection methods Within the last decade, rapid bacterial detection systems ( RBDS ) were developed as an alternative option to culture systems. In RBDS , testing time is reduced to 2–3 h. Therefore, a negative‐to‐date release concept is not necessary using these systems. New technologies In addition, new technologies are currently in development to detect bacterial strains in blood components. Electrochemical biosensors were developed for many different analytes, which range in size from individual ions and small molecules to nucleic acids and proteins up to whole viruses and bacteria. Conclusions Bacterial detection in blood components, especially in platelets, is implemented in many blood donor services. New approaches are promising to come to a next level to be implemented into routine screening, but the analytical sensitivity has to be improved for some of the new test systems in the coming years. Due to the fact that a risk for bacterial contamination still occurs in all blood components, the focus in transfusion medicine in the next decade will be the development of general principles and strategies to detect or inactivate bacteria in all blood components. Therefore, new developments are gladly welcome.
Pseudorandom signals as key words in an associative holographic memory (1979)

A proposal is made that pseudorandom binary signals be used as key words in an associative holographic memory because this extends considerably the range of different key words. An experimental check is reported of generation of key words with the aid of optically controlled transparencies, and of the correlation characteristics of some pseudobinary signals.
Triblock Copolymers with Grafted Fluorine-Free, Amphiphilic, Non-Ionic Side Chains for Antifouling and Fouling-Release Applications (2011)

Fluorine-free, amphiphilic, nonionic surface active block copolymers (SABCs) were synthesized through chemical modification of a polystyrene-block-poly(ethylene-ran-butylene)-block-polyisoprene triblock copolymer precursor with selected amphiphilic nonionic Brij and other surfactants. Amphiphilicity was imparted by a hydrophobic aliphatic group combined with a hydrophilic poly(ethylene glycol) (PEG) group-containing moiety. The surfaces were characterized by dynamic water contact angle, atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and near edge X-ray absorption fine structure (NEXAFS) analysis. In biofouling assays, settlement (attachment) of both spores of the green alga Ulva and cells of the diatom Navicula on SABCs modified with Brij nonionic side chains was significantly reduced relative to a PDMS standard, with a nonionic surfactant combining a PEG group and an aliphatic moiety demonstrating the best performance. Additionally, a fouling-release assay using sporelings (young plants) of Ulva and Navicula suggested that the SABC derived from nonionic Brij side chains also out-performed PDMS as a fouling-release material. Good antifouling and fouling-release properties were not demonstrated for the other two amphiphilic surfaces derived from silicone and aromatic group containing nonionic surfactants included in this study. The results suggest that small differences in chemical surface functionality impart more significant changes with respect to the antifouling settlement and fouling-release performance of materials than overall wettability behavior.
Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors? (2004)

Hematopoietic progenitors are cells, which under challenging experimental conditions can develop unusual phenotypic properties, rather distant from their original mesodermal origin. As previously reported, cells derived from human umbilical cord blood (HUCB) or human bone marrow (BM) under certain in vivo or in vitro conditions can manifest neural features that resemble features of neural-derived cells, immunocytochemically and in some instances also morphologically. The present study explored how hematopoietic-derived cells would respond to neurogenic signals from the subventricular zone (SVZ) of adult and aged (6 and 16 months old) rats. The mononuclear fraction of HUCB cells was transplanted into the SVZ of immunosuppressed (single cyclosporin or three-drug treatment) animals. The triple-suppression paradigm allowed us to protect transplanted human cells within the brain and to explore further their phenotypic and migratory properties. One week after implantation, many surviving HUCB cells were located within the SVZ and the vertical limb of the rostral migratory stream (RMS). The migration of HUCB cells was restricted exclusively to the pathway leading to the olfactory bulb. In younger animals, grafted cells navigated almost halfway through the vertical limb, whereas, in the older animals, the migration was less pronounced. The overall cell survival was greater in younger animals than in older ones. Immunocytochemistry for surface CD antigen expression showed that many HUCB cells, either cultured or within the brain parenchyma, retained their hematopoietic identity. A few cells, identified by using human-specific antibodies (anti-human nuclei, or mitochondria) expressed nestin and doublecortin, markers of endogenous neural progenitors. Therefore, it is believed that the environment of the neurogenic SVZ, even in aged animals, was able to support survival, "neuralization," and migratory features of HUCB-derived cells.
Learning to Assign Orientations to Feature Points (2015)

We show how to train a Convolutional Neural Network to assign a canonical orientation to feature points given an image patch centered on the feature point. Our method improves feature point matching upon the state-of-the art and can be used in conjunction with any existing rotation sensitive descriptors. To avoid the tedious and almost impossible task of finding a target orientation to learn, we propose to use Siamese networks which implicitly find the optimal orientations during training. We also propose a new type of activation function for Neural Networks that generalizes the popular ReLU, maxout, and PReLU activation functions. This novel activation performs better for our task. We validate the effectiveness of our method extensively with four existing datasets, including two non-planar datasets, as well as our own dataset. We show that we outperform the state-of-the-art without the need of retraining for each dataset.
Spangolite: ans= 1/2 maple leaf lattice antiferromagnet? (2011)

Spangolite, Cu(6)Al(SO(4))(OH)(12)Cl·3H(2)O, is a hydrated layered copper sulfate mineral. The Cu(2+) ions of each layer form a systematically depleted triangular lattice which approximates a maple leaf lattice. We present details of the crystal structure, which suggest that in spangolite this lattice actually comprises two species of edge linked trimers with different exchange parameters. However, magnetic susceptibility measurements show that despite the structural trimers, the magnetic properties are dominated by dimerization. The high temperature magnetic moment is strongly reduced below that expected for the six s = 1/2 in the unit cell.
Optimisation de la transparence acoustique de cloison par contrôle actif du champ incident (2010)

National audience
Algorithma 99 (2000)

This paper reports on our experience in achieving reusability and using component-based software engineering in the Algorithma 99 (Algorithm Animation) Project. We show how we extended and reused Algorithma 98 [2] into Algorithma 99 and how we prepared Algorithma 99 to be reused in Algorithma 2000 (to be implemented in Winter 2000). Component-based software engineering is not only confined to binary components, such as COM and CORBA, but is also applicable to software processes, architectures and design, and object-oriented libraries.
Advances in the understanding and management of angioimmunoblastic T‐cell lymphoma (2009)

Angioimmunoblastic T-cell lymphoma (AITL) is a distinct peripheral T-cell lymphoma (PTCL) entity with peculiar clinical and pathological features. The recent identification of follicular helper T (T(FH)) cell as the cell of origin of this neoplasm represents a major step in our understanding of the pathobiological characteristics of the disease and should, in the future, clarify the diagnostic criteria for AITL and help to delineate its spectrum, especially from PTCL, not otherwise specified (PTCL, NOS). Deciphering the pathogenesis of the disease is needed to identify targets for new therapies that are expected to improve the poor outcome of AITL patients, when treated with conventional chemotherapy regimens. In this respect, efforts will be needed to evaluate promising innovative therapies in prospective clinical trials.
Small Mercury Ion Clock for On-board Spacecraft Navigation (2004)

I.Small Ion Clock Approach and Heritage: a) No lasers, uwave cavities, cryogenics, atomic beams, etc. b) Ions are electrically shuttled between separate optical and microwave traps. II. Each trap is optimized for its task: quadrupole for optical state selection; multi-pole for microwave clock. a) Very good stability shown in USNO. Timescale running open loop. III. Open loop operation means no self-measurements of frequency offsets: (Zeeman, ion temperature,... etc.) a) Fewer parts and procedures, produces stable output continuously. IV. Ion clock is not so sensitive to temperature fluctuations a) Measured u:nshielded temperature coefficient of few 10(exp -15) per C. b) No bulky temperature isolation needed.
EFFECT OF PINEALECTOMY ON SERUM MELATONIN, LUTEINIZING HORMONE AND PROLACTIN: A CASE REPORT (1985)

A patient, aged 47 is described in whom changes in hormonal profiles were observed following surgical excision of the pineal. She presented with a clinical syndrome of increased intracranial pressure and postmenopausal symptoms. Computerized tomographic scans showed obstructive hydrocephalus from a cystic lesion in the pineal region. Surgical removal of the cystic mass revealed a benign ependymal cyst and normal pineal tissue. After the operation, she had no nocturnal increase in serum melatonin. The morning basal LH was further elevated and night-time PRL showed little fluctuation from the basal levels.
Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation (2018)

This study assesses the efficacy and exposure-response relationship of omega-3-carboxylic acids (OM-3 CA) in models of crystal-based inflammation. Human THP-1 macrophages and primary peripheral blood mononuclear cells exposed to multiple inflammatory crystal types were used to determine the anti-inflammatory potential of omega-3 (OM-3) fatty acids in vitro. Anti-inflammatory effects of OM-3 CA in vivo were tested in rat monosodium urate (MSU) crystal air pouch and rat knee intra-articular MSU injection models. Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1β (IL-1β) production in vitro. In vivo, OM-3 CA dose-dependently reduced crystal-mediated cell migration, exudate volume, and levels of IL-1β and prostaglandin E<sub>2</sub>. Following intra-articular injection of MSU, treatment with OM-3-CA (1 mL/kg) and indomethacin (1 mg/kg) resulted in similar mean reductions in pain (23% and 41%, respectively) and swelling (58% and 50%, respectively), compared with controls. Additionally, in complex formulations of OM-3 fatty acids, high levels of palmitic acid could reduce the in vivo effect on crystal-mediated IL-1β elevation. OM-3 CA has a broadly efficacious anti-inflammatory effect with a strong exposure-response relationship that could be beneficial in prevention and treatment of crystal arthritis, with potential applications in other IL-1β-mediated diseases.
Data from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation (2023)

&lt;div&gt;Abstract&lt;p&gt;Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here, we show that EZH2 and NRAS&lt;sup&gt;G12D&lt;/sup&gt; mutations cooperatively induce progression of myeloproliferative neoplasms to highly penetrant, transplantable, and lethal myeloid leukemias in mice. EZH1, an EZH2 homolog, is indispensable for EZH2-deficient leukemia-initiating cells and constitutes an epigenetic vulnerability. BCAT1, which catalyzes the reversible transamination of branched-chain amino acids (BCAA), is repressed by EZH2 in normal hematopoiesis and aberrantly activated in EZH2-deficient myeloid neoplasms in mice and humans. BCAT1 reactivation cooperates with NRAS&lt;sup&gt;G12D&lt;/sup&gt; to sustain intracellular BCAA pools, resulting in enhanced mTOR signaling in EZH2-deficient leukemia cells. Genetic and pharmacologic inhibition of BCAT1 selectively impairs EZH2-deficient leukemia-initiating cells and constitutes a metabolic vulnerability. Hence, epigenetic alterations rewire intracellular metabolism during leukemic transformation, causing epigenetic and metabolic vulnerabilities in cancer-initiating cells.&lt;/p&gt;Significance:&lt;p&gt;EZH2 inactivation and oncogenic NRAS cooperate to induce leukemic transformation of myeloproliferative neoplasms by activating BCAT1 to enhance BCAA metabolism and mTOR signaling. We uncover a mechanism by which epigenetic alterations rewire metabolism during cancer progression, causing epigenetic and metabolic liabilities in cancer-initiating cells that may be exploited as potential therapeutics.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Li and Melnick, p. 1158&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 1143&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Conjugate addition reactions of vinyl sulfones with hard nucleophiles (2005)

The conjugate addition reactions of several vinyl sulfones with hard oxygen nucleophiles are discussed. In particular a general method for the preparation of β-hydroxy sulfones under Weitz–Scheffer epoxidation conditions is described.
Four channel Laser Firing Unit using laser diodes (1994)

This paper describes the accomplishments and status of PS/EDD's (Pacific Scientific/Energy Dynamics Division) internal research and development effort to prototype and demonstrate a practical four channel laser firing unit (LFU) that uses laser diodes to initiate pyrotechnic events. The LFU individually initiates four ordnance devices using the energy from four diode lasers carried over the fiber optics. The LFU demonstrates end-to-end optical built in test (BIT) capabilities. Both Single Fiber Reflective BIT and Dual Fiber Reflective BIT approaches are discussed and reflection loss data is presented. This paper includes detailed discussions of the advantages and disadvantages of both BIT approaches, all-fire and no-fire levels, and BIT detection levels. The following topics are also addressed: electronic control and BIT circuits, fiber optic sizing and distribution, and an electromechanical shutter type safe/arm device. This paper shows the viability of laser diode initiation systems and single fiber BIT for typing military applications.
Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles (2005)

Micro-needle arrays increase skin permeability by forming channels through the outer physical barrier, without stimulating pain receptors populating the underlying dermis. It was postulated that micro-needle arrays could facilitate transfer of DNA to human skin epidermis for cutaneous gene therapy applications. Platinum-coated "wet-etch" silicon micro-needles were shown to be of appropriate dimensions to create micro-conduits, approximately 50 microm in diameter, extending through the stratum corneum (SC) and viable epidermis. Following optimisation of skin explant culturing techniques and confirmation of tissue viability, the ability of the micro-needles to mediate gene expression was demonstrated using the beta-galactosidase reporter gene. Preliminary studies confirmed localised delivery, cellular internalisation and subsequent gene expression of pDNA following micro-needle disruption of skin. A combination of this innovative gene delivery platform and the ex vivo skin culture model will be further exploited to optimise cutaneous DNA delivery and address fundamental questions regarding gene expression in skin.
Pulmonary artery interventions after the arterial switch operation: Unique and significant risks (2019)

Background In the modern era, results of the arterial switch operation (ASO) for transposition of the great arteries are excellent. However, because of the LeCompte maneuver, there may be a propensity for development of pulmonary artery stenosis. We encountered atypical complications of pulmonary artery stenting in patients after the ASO, including aorto-pulmonary fistula and coronary compression. Methods We performed a 10-year retrospective review of catheterizations performed in patients after ASO in our institution with a focus on adverse events. Results Diagnostic and interventional catheterizations were performed in 47 patients. In 29 patients, 37 interventional procedures performed, which included pulmonary artery angioplasty and/or stenting. In this group, there were five major adverse events (14%), including three aorto-pulmonary fistulae and one coronary artery compression among patients having stent implantation or stent redilation. In addition, there were 6/37 (16%) intended stent procedures, which were aborted because there appeared to be high-risk of significant adverse events. Conclusions This review suggests that percutaneous intervention on pulmonary artery stenosis after ASO has high-risk and should be undertaken advisedly. Prior thorough evaluation of coronary arteries is mandatory as coronary reimplantation sites may be adjacent to sites of pulmonary artery stenosis. Furthermore, if pulmonary artery stent implantation or stent redilation is contemplated, the risk of stent fracture and possible AP fistula should be recognized. Primary use of reinforced covered stents should be considered.
KEAML - Key Exchange and Authentication Markup Language (2006)

It is not uncommon that an enterprise application-level business entity in one security domain needs to be engaged in protected information exchanges across unsecured public networks with a number of other entities from separate security domains in an ad-hoc fashion. Neither having a trusted central authority to manage this activity nor a proprietary security handshake protocol designed for particular applications works; the former is often impractical while the latter lacks interoperability and typically cannot be massively deployed. Experience has also shown that proprietary protocols are usually very weak and vulnerable to a variety of attacks. It is desirable to have a standardized protocol for mutual key exchange and authentication that is resistant to a variety of attacks, scalable, and sufficiently flexible to be deployed in a number of different application environments. Unfortunately, no such standard has been developed for enterprise-level applications and services. This paper defines an XML-based key exchange and authentication framework along with a protocol, with concepts such as two-phase negotiation, standardized key exchange templates that resist attack, and public components for Diffie-Hellman exchange borrowed from ISAKMP/IKE (the layer 3 security framework and protocol for VPN). The proposed protocol also leverages the W3C XML encryption and XML signature specifications to allow field-level encryption and signing of KEAML protocol messages, where required
Reduced Phytic Acid Content Does Not Have an Adverse Effect on Germination of Soybean Seeds (1985)

Altering the level of phytic acid phosphorus by nutritional means had no effect on the ability of soybean (Glycine max L. [Merr.], cv ;Williams 79') seeds to germinate under laboratory or greenhouse conditions. Dry matter moved out of the cotyledons at similar rates whether the germinating seeds initially contained low (0.19), medium (0.59), or high (1.00 milligram per seed) phytic acid phosphorus. Growth of roots and shoots from 3 to 9 days after planting was similar for seeds containing low and medium levels of phytic acid phosphorus. The medium level of phytic acid resembles that found in field-grown seed, so it is clear that soybean seeds normally contain a phosphorus reserve far above that needed for germination and early seedling growth.