gebhart/patrepeval huggingface dataset:
Hemagglutinin‐33 of type A botulinum neurotoxin complex binds with synaptotagmin II (2005)

Botulinum neurotoxin type A (BoNT/A), the most toxic substance known to mankind, is produced by Clostridium botulinum type A as a complex with a group of neurotoxin-associated proteins (NAPs) through polycistronic expression of a clustered group of genes. NAPs are known to protect BoNT against adverse environmental conditions and proteolytic digestion. Hemagglutinin-33 (Hn-33) is a 33 kDa subcomponent of NAPs that is resistant to protease digestion, a feature likely to be involved in the protection of the botulinum neurotoxin from proteolysis. However, it is not known whether Hn-33 plays any role other than the protection of BoNT. Using immunoaffinity column chromatography and pull-down assays, we have now discovered that Hn-33 binds to synaptotagmin II, the putative receptor of botulinum neurotoxin. This finding provides important information relevant to the design of novel anti-botulism therapeutic agents targeted to block the entry of botulinum neurotoxin into nerve cells.
Synthesis and Magnetic Properties of Mesoporous Vanadium Oxide Sulphate (2002)

Abstract Preparation and magnetic properties of mesostructured VOSO4 based materials, which were synthesized using liquid-crystal templating technique, have been investigated. Low temperature magnetic properties of the samples exhibited Langevin paramagnetism with an effective magnetic moment μeff=1.4 μB and a paramagnetic Curie point θ=0 K without any magnetic transition, which were considerably different from magnetic properties of α- or β-VOSO4 crystals.
Effects of low concentrations of guanidine hydrochloride on pig heart lipoamide dehydrogenase (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of low concentrations of guanidine hydrochloride on pig heart lipoamide dehydrogenaseColin Thorpe and Charles H. Williams, Jr.Cite this: Biochemistry 1974, 13, 16, 3263–3268Publication Date (Print):July 1, 1974Publication History Published online1 May 2002Published inissue 1 July 1974https://pubs.acs.org/doi/10.1021/bi00713a013https://doi.org/10.1021/bi00713a013research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
How context shapes the appropriateness of a robot’s voice (2020)

Social robots have a recognizable physical appearance, a distinct voice, and interact with users in specific contexts. Previous research has suggested a `matching hypothesis', which seeks to rationalise how people judge a robot's appropriateness for a task by its appearance. Other research has extended this to cover combinations of robot voices and appearances. In this paper, we examine the missing connection between robot voice, robot appearance, and deployment context. In so doing, we asked participants to match a robot image to a voice within a defined interaction context. We selected widely available social robots, identified task contexts they are used in, and manipulated the voices in terms of gender, naturalness, and accent. We found that the task context mediates the `matching hypothesis'. People consistently selected a robot based on a vocal feature for a certain context, and a different robot based on the same vocal feature for another context. We suggest that robot voice design should take advantage of current technology that enables the creation and tuning of custom voices. They are a flexible tool to increase perception of appropriateness, which has a positive influence on Human-Robot Interaction.
Salivary MicroRNA in Pancreatic Cancer Patients (2015)

Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer.
72-HOUR PRESERVATION OF THE CANINE PANCREAS (1987)

A new flushout solution for preservation of the pancreas was tested in the dog model of segmental pancreas autotransplantation. The solution osmolality was 320 mOsm/L, K+ = 120 mM, Na+ = 30 mM, and it contained the anion, lactobionate, and raffinose as impermeants to the cell. Preservation times studied were 48 and 72 hr. The pancreas was flushed out with about 250 ml of the new solution and stored at 0 degrees C. Dogs were monitored postoperatively for blood glucose and intravenous glucose tolerance (IVGTT). Results were compared with control (no preservation) segmental pancreas autotransplants. Dogs receiving pancreases stored for 48 or 72 hr were normoglycemic on day one and remained normoglycemic for at least 28 days, or until time of sacrifice. Two of four dogs with pancreases stored for 48 hr were sacrificed on day 14 with normal IVGTT for histology. The remaining two dogs had normal pancreatic function for 28 days. Two of eight dogs receiving pancreas grafts after 72-hr cold storage died of causes unrelated to the pancreas graft, which was still functioning at the time of death. Six dogs remained normoglycemic and had a normal IVGTT at least for 28 days. This study demonstrates the feasibility of preserving the pancreas for three days for transplantation.
Implementing a high-volume, low-latency market data processing system on commodity hardware using IBM middleware (2009)

A stock market data processing system that can handle high data volumes at low latencies is critical to market makers. Such systems play a critical role in algorithmic trading, risk analysis, market surveillance, and many other related areas. We show that such a system can be built with general-purpose middleware and run on commodity hardware. The middleware we use is IBM System S, which has been augmented with transport technology from IBM WebSphere MQ Low Latency Messaging. Using eight commodity x86 blades connected with Ethernet and Infiniband, this system can achieve 80 μsec average latency at 3 times the February 2008 options market data rate and 206 μsec average latency at 15 times the February 2008 rate.
Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells (2005)

Purmorphamine is a novel small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells, but there has been no evaluation of its effect on human cells to date. The aim of this study was to investigate the induction of osteogenic activity by purmorphamine in human osteoblasts differentiated from bone marrow mesenchymal cells. Cells were cultured in 24-well plates at a density of 2x10(4)/well in medium containing 1, 2 or 3 microM purmorphamine, or vehicle. At 7, 14 and 21 days, cell proliferation, viability, and alkaline phosphatase (ALP) activity were evaluated. Bone-like nodule formation was evaluated at 21 days. Purmorphamine did not affect cell proliferation or viability, but increased ALP activity and bone-like nodule formation. These results indicate that events related to osteoblast differentiation, including increased ALP activity and bone-like nodule formation, are enhanced by purmorphamine.
Correlation of room acoustic parameters and noise level in eating establishments (2023)

This article addresses the impact of the occupancy level, the average acoustic absorption and the so-called acoustic capacity of a space, which is proportional with the volume and inversely proportional with the reverberation time, on the behavior of talking people in an eating establishments. Four different settings were compared: two casual dining restaurants, a self-service student canteen and a small faculty club. The Lombard effect was observed in all cases. In a restaurant with an average amount of absorbing surface of 2.4 m 2 or more per person, the sound pressure level increased with more than 3 dB per doubling of the number of people. Results for the student canteen show that people started to communicate less when the number of people present was so high that the absorbing surface dropped under 1.5 m 2 /person (80 people). The level even stopped to increase with increasing occupancy from 150 people present and beyond, corresponding with 0.8 m 2 of absorbing surface per person. This is roughly consistent with an estimated value for the acoustic capacity of that space, which was 189 people (corresponding with a table occupancy of about 72%). In the latter circumstances, the background noise level, as expressed by L A,95 was as high as 69 dB. Overcoming this level for oral communication would require a not sustainable vocal effort. In the tests performed in other restaurants, the observed occupancy was below 60%, which, thanks to the higher number of absorbing surfaces in those restaurants, was well below the acoustic capacity.
P596 Altered calcium homeostasis and the disease activity in patients with Crohn's disease and ulcerative colitis (2013)

Background: Efforts have been made to optimize the use of available therapies to improve Crohn's disease (CD) outcome, but up to now no therapy changed the natural history of the disease.Mucosal healing (MH) appears as a therapeutic goal able to predict sustained clinical remission.Therapy with anti-TNF a antibodies, Infliximab (IFX) and Adalimumab (ADA), have been proven effective in achieving MH with a more potent and rapid effect compared to immumomodulants (IMM).No pediatric studies evaluating MH as a therapeutic goal are available.Aim of our study is to assess the efficacy of IFX and ADA in obtaining MH in a pediatric CD cohort.Secondary aim is to evaluate differences in response in children with early (<1 year) or late (>1 year) disease.Methods: CD patients (pts), between 6 and 18 years of age, starting IFX or ADA from January 2009 were enrolled.All pts were naïve to biological therapies but could have been previously treated with corticosteroids, IMM and aminosalycilates.Pts' characteristics collected at baseline are: age at diagnosis, indication for therapy, age at enrollment, disease duration and location, and concomitant medications.An endoscopic procedure was performed before starting biologics and after 9 to12 months to evaluate MH.Clinical and endoscopic disease activity were assessed by Pediatric Crohn's Disease Activity Index (PCDAI) and Simple Endoscopic Score (SES CD) respectively at time 0 (T0) and at the time of endoscopic follow-up (FU).Pts underwent anti-TNF a therapy with appropriate induction and maintenance therapeutic schemes.Results: Thirty-one pts (21 IFX and 10 ADA) were enrolled, 18 males.At enrollment mean age was 12.7±2.9years and mean disease duration was 13±15.3months.Fifteen pts (6 IFX) were in the early disease group, 16 (15 IFX) in the late disease group.At T0 16 pts (52%) were on IMM, 10 of them were still on IMM at FU. Mean±SD values of PCDAI and SES CD at T0 and FU are 30±17.6and 11.3±11.5, and 15.5±8.6 and 6.5±7.5 respectively; both values were significantly reduced at FU (p < 0.05).Dividing patients on the basis of disease duration prior to therapy SES CD values decreased significantly at FU both in early and in late disease pts, however more significantly in the first group (p < 0.0001 vs 0.02).Conclusions: In our cohort biological therapy appears effective in achieving MH, probably more effectively if introduced early in the course of the disease.Larger studies with longer FU will highlight the effect of MH on disease evolution.
Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-α Gene-Targeted Mice (1999)

Abstract We have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both NK cell-mediated tumor rejection and protection from experimental metastases were significantly compromised in LT-α-deficient mice. Analysis of LT-α-deficient mice revealed that the absolute number of αβTCR− NK1.1+ NK cells was reduced in bone marrow and thymus, but with overall proportional decreases in other hemopoietic organs. In addition, the antitumor potential of αβTCR− NK1.1+ cells, as determined by their lytic capacity and perforin expression, was reduced 1.5- to 3-fold in LT-α-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-α-deficient mice.
The technology of cement and concrete (1955)

THE MAIN EMPHASIS OF THIS VOLUME IS ON PORTLAND CEMENT AND AGGREGATES. THE PART ON AGGREGATES COVERS CONCRETE AGGREGATE MATERIALS, GEOLOGY AND PETROGRAPHY, EFFECT OF AGGREGATE PROPERTIES ON CONCRETE, PROSPECTING, EXPLORATION, SAMPLING AND TESTING, AND THE PROCESSING OF CONCRETE AGGREGATES.
<title>Recent developments in plastic optical fiber components for automotive applications</title> (1993)

The majority of production applications using plastic optical fiber (POF) have been for illumination applications. These applications continue to be refined and new illumination applications continue to be introduced. Point-to-point data communication applications of POF are beginning to appear in production vehicles. New developments in connection systems and networking components are occurring rapidly. This paper discusses recently developed components for illumination and data communications. The illumination components were designed for three different applications: lamp monitoring, keyhole illumination, and PRNDL indication (gear shift). Components for data communications include two connection systems and two passive stars designed for networking. The two connections systems are a 16 electrical/1 optical system for point-to-point links and a 5 electrical/2 optical for two-way optical communications. The two stars are a 16 node star and 7 node star. Performance characteristics and design advantages are described for all components.
Focusing Hard X-rays to Sub-50 nm Size by Elliptically Figured Mirror (2005)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Yumoto, H. Mimura, S. Matsuyama, H. Hara, K. Yamamura, Y. Sano, K. Ueno, K. Endo, Y. Mori, M. Yabashi, Y. Nishino, K. Tamasaku, T. Ishikawa, and K. Yamauchi, "Focusing Hard X-rays to Sub-50 nm Size by Elliptically Figured Mirror," in Frontiers in Optics, OSA Technical Digest Series (Optica Publishing Group, 2005), paper JWA10. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
DISCRIMINATION BETWEEN PINE SHOOTS WITH AND WITHOUT OVIPOSITION BY PISSODES TERMINALIS HOPPING (COLEOPTERA: CURCULIONIDAE) (1995)

The lodgepole terminal weevil, Pissodes terminalis Hopping, is the only member of its genus that consistently oviposits in the expanding terminal shoots of its hosts (Stark and Wood 1964). The white pine weevil, Pissodes strobi (Peck), oviposits in the year old shoot of spruce and pine (Wallace and Sullivan 1985) and other Pissodes species have their oviposition sites on boles, root collars, and slash (Furniss and Carolin 1977). In southern British Columbia, P. terminalis is primarily univoltine although adults may live and oviposit for 2 or more years. Although its life cycle is closely synchronized with terminal phenology, its life history is extremely variable (Cameron and Stark 1989). Adults are active in late spring to early summer, when they can be found feeding on the tissues of the developing terminal shoot and foliage. Soon after this maturation feeding, mating occurs, and oviposition punctures are excavated in the bark of the new terminal. Usually a single egg is deposited into each puncture (Drouin et al. 1963; Stark and Wood 1964; Maclauchlan 1992).
DEVELOPMENT OF A PRECISION SPRAYER FOR SITE-SPECIFIC WEED MANAGEMENT (1999)

A machine-vision-system-guided precision sprayer was developed and tested. The long-term objectives of thisproject were to develop new technologies to estimate weed density and size in real time, realize site-specific weed control,and effectively reduce herbicide application amounts for corn and soybean fields. This research integrated a real-timemachine-vision sensing system with an automatic herbicide sprayer to create an intelligent sensing and spraying system.Multiple video images were used to cover the target area. To increase the accuracy, each individual spray nozzle wascontrolled separately. Instead of trying to identify each individual plant in the field, weed infestation zones (0.254 m 0.34 m) were detected. The integrated system was tested to evaluate the effectiveness and performance under varying fieldconditions. With the current system design, and using 0.5% weed coverage as the control zone threshold, herbicidesavings of 48% could be realized.
El desarrollo sostenible humano local: La evolución de la inclusión del territorio en las teorías del desarrollo / Human Sustainable Development at a Local Level – How Territory has been included in Theories of Development (2019)

La investigacion pretende generar una base analitica de una nueva concepcion teorica asociada al desarrollo sostenible humano local. Para lo cual se estudia el tipo de inclusion de la unidad de analisis de lo territorial, en diversas perspectivas teoricas influidas por enfoques de crecimiento o desarrollo. Se estudian teorias como el desarrollo endogeno, desarrollo Economico Local, el centro-periferia, cluster, distritos industriales, cadenas globales de valor, contexto de negocios, estrategias de desarrollo territorial, para justificar la propuesta del desarrollo sostenible humano local (DSHL). El cual articula estrategias en torno a 7 capitales endogenos de los territorios, que se gestionan en escenarios prospectivos de corto, mediano y largo plazo. Se concluye identificando las falencias que debe atender la nueva perspectiva del DSHL / This work is aimed at examining a new theoretical conception of human sustainable development at a local level. For this, it is analyzed how the concept of territory has been included in such theories of development as endogenous development, local economic development, center-periphery model, cluster theory, industrial district concept, global value chains, business context, territorial development strategy, for achieving human sustainable development at a local level. Some strategies for managing seven endogenous resources in territories in short, medium, and long-term prospective scenarios are suggested. Challenges to human sustainable development at a local level are identified.
Synthesis and encapsulation of iron iodate (Fe(IO3)3) hybrid particles using water-in-oil (W/O) miniemulsion polymerization (2012)

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The effect of sorbed penetrants on the aging of previously dilated glassy polymer powders. IV (1991)

Abstract Uniform, submicron‐diameter polystyrene (PS) and poly(methylmethacrylate) (PMMA) microspheres were dilated by preswelling with pure organic vapors followed by rapid removal of the preswelling penetrant by protracted evacuation of the preswelling chamber to a pressure of 10 −3 mm Hg. Aging of the preswollen polymers was carried out both in vacuum and in the presence of various penetrants at sorbed concentrations typically less than 2 wt%. Inferences about relaxations of the polymers were based upon changes in concentrations of the penetrants within the microspheres, at a given temperature and penetrant activity, which result from aging in vacuum or in the presence of penetrant. The kinetics of the relaxations were monitored by probing the expanded glasses with relatively low concentrations of penetrants. In general, the continuous presence of these low concentrations of probe molecules either arrested or retarded the ensuing relaxation as compared with the aging that occurred in vacuum. A series of lower monohydric alcohols, lower n ‐alkanes, and some other similar penetrants were used as probes to test explicitly and systematically the effects of size and structure of the penetrant contacting the polymer during aging on the decay of excess sorption capacity of the preswollen glassy polymers. Decay of excess sorption in the presence of penetrant was evident only when molecularly small penetrants with interactive functional groups, alcohols for example, were sorbed into preswollen PMMA. This result suggested that the relaxation occurring in the presence of penetrant involved specific interactions between the penetrants and the carbonyl groups in the PMMA.
Parathyroid adenoma within the vagus nerve. (1994)

Parathyroid adenoma within the vagus nerve.J L Doppman, T H Shawker, D L Fraker, H R Alexander, M C Skarulis, E E Lack and A M SpiegelAudio Available | Share
Supplementary Data 1 from Prostatic Acid Phosphatase Is Not a Prostate Specific Target (2023)

Supplementary Data 1 from Prostatic Acid Phosphatase Is Not a Prostate Specific Target
Interaction of Lipoproteins with Heparan Sulfate Proteoglycans and with Lipoprotein Lipase. Studies by Surface Plasmon Resonance Technique (1997)

Interaction of different classes of lipoproteins with heparan sulfate, heparin, and lipoprotein lipase was studied by a surface plasmon resonance based technique on a BIAcore. The proteoglycans were covalently attached to sensor chips as previously described [Lookene, A., Chevreuil, O., Ostergaard, P., & Olivecrona, G. (1996) Biochemistry 35, 12155-12163]. Binding of all lipoproteins, except for beta-VLDL, to endothelial heparan sulfate was low. Binding of chylomicrons (from rat lymph) and of human VLDL was much increased by the presence of lipoprotein lipase. With human LDL, binding was low in the absence of lipase or at low lipase concentrations. For efficient binding, 2-4 lipase dimers per LDL particle were necessary, indicating cooperativity in the interaction. In contrast, HDL did not bind under any conditions. Heparin had higher binding capacity for lipoproteins than heparan sulfate. This was due to a higher number of binding sites on the heparin chains. Binding of LDL, VLDL, and chylomicrons to heparan sulfate-covered surfaces, both in the presence and in the absence of lipoprotein lipase, was characterized by high values for association rate constants (10(4)-10(5) M(-1) s(-1)) and low values for dissociation rate constants (10(-4)-10(-5) M(-1) s(-1)). In some experiments, rabbit beta-VLDL were directly immobilized to the sensor chips. Binding of lipoprotein lipase to these surfaces was characterized by a very high association rate constant (10(6) M(-1) s(-1)). The dissociation of triacylglycerol-rich lipoproteins was more rapid with catalytically active lipase than with active site-inhibited lipase. It was also markedly increased in the presence of free heparin, suggesting fast exchange kinetics at the surface. Based on that, we propose that lipoproteins are relatively mobile at heparan sulfate covered surfaces. Our study emphasizes the important role of lipoprotein lipase, or molecules with similar properties (apolipoprotein E, hepatic lipase), as mediators for binding of lipoproteins to proteoglycans. It also demonstrates the great potential for the use of biosensors for studies of lipoprotein interactions.