gebhart/patrepeval huggingface dataset:
Stochastische Modellierung von Bildsequenzen zur Segmentierung und Erkennung dynamischer Gesten (2000)

In der Arbeit wird die Entwicklung eines bildverarbeitungsgestutzten Systems fur den mit Handgesten gesteuerten Mensch-Maschine-Dialog vorgestellt. Mit zwei alternativen Ansatzen, die auf der stochastischen Modellierung mit teilweise modifizierten und erweiterten Hidden-Markov-Modellen beruhen, werden gestische Bewegungen im kontinuierlichen Videostrom zeitlich segmentiert und klassifiziert. Zur Anpassung der raumlich-zeitlichen Bildsequenzen des Videostroms an die serielle Verarbeitung der Hidden-Markov-Modelle werden mehrere Merkmalsextraktionsverfahren entwickelt und vergleichend untersucht. Als Beispielanwendung wird die Implementierung eines echtzeitfahigen dreidimensionalen Szenen-Editors beschrieben. Uber das Konzept der indirekten Manipulation im Zusammenspiel mit dynamischen Gesten sind hierin auch komplexe Aktionen intuitiv steuerbar.
Hand Pose Guided 3D Pooling for Word-level Sign Language Recognition (2021)

Gestures in American Sign Language (ASL) are characterized by fast, highly articulate motion of upper body, including arm movements with complex hand shapes and facial expressions. In this work, we propose a new method for word-level sign recognition from American Sign Language (ASL) using video. Our method uses both motion and hand shape cues while being robust to variations of execution. We exploit the knowledge of the body pose, estimated from an off-the-shelf pose estimator. Using the pose as a guide, we pool spatio-temporal feature maps from different layers of a 3D convolutional neural network. We train separate classifiers using pose guided pooled features from different resolutions and fuse their prediction scores during test time. This leads to a significant improvement in performance on the WLASL benchmark dataset [25]. The proposed approach achieves 10%, 12%, 9.5% and 6.5% performance gain on WLASL100, WLASL300, WLASL1000, WLASL2000 subsets respectively. To demonstrate the robustness of the pose guided pooling and proposed fusion mechanism, we also evaluate our method by fine tuning the model on another dataset. This yields 10% performance improvement for the proposed method using only 0.4% training data during fine tuning stage.
2017 IEEE 19th Conference on Business Informatics: Proceedings : Volume 1: Conference Papers (2017)

2017 IEEE 19th Conference on Business Informatics: Proceedings : Volume 1: Conference Papers
General Management of the Gunshot Victim With Musculoskeletal Injury (2006)

Summary: Gunshot wounds to the extremities are rarely lethal, but often morbid injury. As with all trauma patients, evaluation and stabilization of the A-B-Cs is essential and exsanguination must be rapidly controlled. The nonbony injuries that are sustained after penetrating extremity trauma include primarily vascular and soft tissue injury. Vascular injury obviously can lead to hemorrhage and disruption of blood flow leading to ischemia and limb loss if untreated. This article reviews some of the modalities available for diagnosis, as well as the treatment options used for vascular repair. The management of soft tissue injuries is similarly described. Compartment syndrome secondary to ischemia, hemorrhage, or limb edema is an extremely morbid sequelae of penetrating injuries to the extremities. Early diagnosis is essential and requires a high index of suspicion from vigilant clinicians. Indications for both prophylactic and therapeutic fasciotomy are reviewed. Complications after gunshot wounds to the extremities, such as thromboses, infections, and rhabdomyolysis, are also discussed.
Comparison of Wideband Channel Sounding Techniques (2009)

This paper compares time-domain and frequency-domain wideband channel sound- ing techniques by using measurement results. These techniques are compared based on the re- ceived power, the multipath resolution, and the RMS delay spread. Similar conclusions can be drawn for both sounding techniques for the measurement environment. In general, both sounding techniques have their own advantages and constrains; the choice of sounding technique heavily depends on the experiment environment.
Double fluorescent labeling method used for a study on liposomes. (1991)

Carboxyfluorescein (CF) and Calcein (CAL) have almost the same fluorescent spectrum. However, only CAL forms a nonfluorescent chelate with the Co2+ ion. It was proven that this phenomenon can be used for the fractional determination of CF and CAL. And this fractional determination method was available for a study on liposomes.
Development of verotoxin 2- and verotoxin 2 variant (VT2v)-specific oligonucleotide probes on the basis of the nucleotide sequence of the B cistron of VT2v from Escherichia coli E32511 and B2F1 (1991)

We and others have noted that there are serological differences between verotoxin 2 (VT2) (also known as Shiga-like toxin II) produced by Escherichia coli C600(933W) and the VT2 variant (VT2v) produced by strain E32511. Recent reports have described nucleotide sequence differences between the VT2v B subunit cistron of E32511 and B2F1 and that of VT2. We have confirmed the sequence differences and have used them to design oligonucleotide probes which differentiate the B subunit cistron of VT2v from that of VT2. Isolates of VT-producing E. coli obtained from human as well as food and veterinary sources were classified according to the toxin phenotype by using a toxin neutralization assay with VT2-specific monoclonal antibody and VT2v-specific polyclonal antisera. Using the oligonucleotide probes in colony hybridization, we detected 35 of 35 VT2 producers and 16 of 16 VT2v producers. One VT2 producer was falsely identified as containing the VT2v gene. The E32511 strain in our collection hybridized only with the VT2-specific probe. Southern hybridization of radiolabeled oligonucleotide probes showed that strains carried zero to one copy of the VT2 gene and zero to two copies of the VT2v gene. We conclude that colony hybridization with the VT2- and VT2-specific probes is highly predictive of the toxin phenotypes in the clinical isolates described in this study.
Fusion Techniques for the Oxidation of Refractory Actinide Oxides (1999)

Small-scale experiments were performed to demonstrate the feasibility of fusing refractory actinide oxides with a series of materials commonly used to decompose minerals, glasses, and other refractories as a pretreatment to dissolution and subsequent recovery operations. In these experiments, 1-2 g of plutonium or neptunium oxide (PuO2 or NpO2) were calcined at 900 degrees Celsius, mixed and heated with the fusing reagent(s), and dissolved. For refractory PuO2, the most effective material tested was a lithium carbonate (Li2CO3)/sodium tetraborate (Na2B4O7) mixture which aided in the recovery of 90 percent of the plutonium. The fused product was identified as a lithium plutonate (Li3PuO4) by x-ray diffraction. The use of a Li2CO3/Na2B4O7 mixture to solubilize high-fired NpO2 was not as effective as demonstrated for refractory PuO2. In a small-scale experiment, 25 percent of the NpO2 was oxidized to a neptunium (VI) species that dissolved in nitric acid. The remaining neptunium was then easily recovered from the residue by fusing with sodium peroxide (Na2O2). Approximately 70 percent of the neptunium dissolved in water to yield a basic solution of neptunium (VII). The remainder was recovered as a neptunium (VI) solution by dissolving the residue in 8M nitric acid. In subsequent experiments with Na2O2, the ratio of neptunium (VII) to (VI) was shown to be a function of the fusion temperature, with higher temperatures (greater than approximately 400 degrees C) favoring the formation of neptunium (VII). The fusion of an actual plutonium-containing residue with Na2O2 and subsequent dissolution was performed to demonstrate the feasibility of a pretreatment process on a larger scale. Sodium peroxide was chosen due to the potential of achieving higher actinide recoveries from refractory materials. In this experiment, nominally 10 g of a graphite-containing residue generated during plutonium casting operations was initially calcined to remove the graphite. Removal of combustible material prior to a large-scale fusion with Na2O2 is needed due to the large amount of heat liberated during oxidation. Two successive fusions using the residue from the calcination and the residue generated from the initial dissolution allowed recovery of 98 percent of the plutonium. The fusion of the residue following the first dissolution was performed at a higher temperature (600 degrees Celsius versus 450 degrees Celsius during the first fusion). The ability to recover most of the remaining plutonium from the residue suggest the oxidation efficiency of the Na2O2 fusion improves with higher temperatures similar to results observed with NpO2 fusion.
A Dislocation-Crystal Plasticity Simulation on Large Deformation Considering Geometrically Necessary Dislocation Density and Incompatibility (2nd Report, Application to FCC Single Crystal) (2006)

In the previous paper, the GN incompatibility is newly defined and a new annihilation term of a dislocation pair due to the dynamic recovery is introduced into an expression of dislocation density. Furthermore, a multiscale model of crystal plasticity is proposed by considering GN dislocation density and incompatibility. However, details of dislocation-crystal plasticity simulation are not given. In this paper, we explain a method of dislocation-crystal plasticity analysis. A finite element simulation is carried out for an f.c.c. single crystal under plane strain tension. It is numerically predicted that micro shear bands are formed at large strain, and sub-GNBs : small angle tilt boundaries are induced along these bands. Furthermore, the annihilation of dislocation pair and the increase of dislocation mean free path characterizing stage III of work-hardening are computationally predicted.
Comparison of assembly techniques for textiles used in pneumatic devices (2014)

The paper presents an original study of several assembly techniques for textiles. The aim of the investigation is to develop a reliable technology which can be readily adapted to the industrial production of pneumatic muscles and active clothing. The research was carried on by means of several experimental tests using various assembly techniques. The woven choice is linked to the future purposes involved in this study. Results obtained are interesting and useful for various kinds of pneumatic systems.
Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells (2015)

Immunosuppressive drugs in clinical transplantation are necessary to inhibit the immune response to donor antigens. Although they are effective in controlling acute rejection, they do not prevent long-term transplant loss from chronic rejection. In addition, immunosuppressive drugs have adverse side effects, including increased rate of infections and malignancies. Adoptive cell therapy with human Tregs represents a promising strategy for the induction of transplantation tolerance. Phase I/II clinical trials in transplanted patients are already underway, involving the infusion of Tregs alongside concurrent immunosuppressive drugs. However, it remains to be determined whether the presence of immunosuppressive drugs negatively impacts Treg function and stability. We tested in vitro and in vivo the effects of tacrolimus, mycophenolate and methylprednisolone (major ISDs used in transplantation) on ex vivo expanded, rapamycin-treated human Tregs. The in vitro results showed that these drugs had no effect on phenotype, function and stability of Tregs, although tacrolimus affected the expression of chemokine receptors and IL-10 production. However, viability and proliferative capacity were reduced in a dose-dependent manner by all the three drugs. The in vivo experiments using a humanized mouse model confirmed the in vitro results. However, treatment of mice with only rapamycin maintained the viability, function and proliferative ability of adoptively transferred Tregs. Taken together, our results suggest that the key functions of ex vivo expanded Tregs are not affected by a concurrent immunosuppressive therapy. However, the choice of the drug combination and their timing and dosing should be considered as an essential component to induce and maintain tolerance by Treg.
Introduction to dimensional analysis and the theory of natural units (1971)

The report presents a somewhat abbreviated introduction to dimensional analysis for students of science or engineering. It shows how to construct a system of consistent natural units appropriate to any given physical problem or context. It also explains how the well known Pi Theorem of dimensional analysis follows from this treatment, and how the dimensionless pi's of the theorem simply represent various physical quantities of interest as expressed in such natural units. The method is illustrated by application to the case of an ideal propeller. This example shows how dimensional analysis may be used to generalize and simplify a problem, and to extract the maximum degree of useful information and insight from its solution. (Author)
Copper(I) Oxide‐Mediated Cyclization of o‐Haloaryl N‐Tosylhydrazones: Efficient Synthesis of Indazoles (2016)

Abstract An efficient synthesis of indazoles from readily accessible E/Z mixtures of o ‐haloaryl N ‐tosylhydrazones has been developed. The thermo ‐induced isomerization of N ‐tosylhydrazones is discussed. A series of valuable indazole derivatives are prepared in good yields, and the method has been successfully applied to the synthesis of the bioactive compounds, lonidamine, AF‐2785, axitinib, YC‐1 and YD‐3. magnified image
Large-Scale Reverse Genetics in Arabidopsis: Case Studies from the Chloroplast 2010 Project (2009)

Traditionally, phenotype-driven forward genetic plant mutant studies have been among the most successful approaches to revealing the roles of genes and their products and elucidating biochemical, developmental, and signaling pathways. A limitation is that it is time consuming, and sometimes technically challenging, to discover the gene responsible for a phenotype by map-based cloning or discovery of the insertion element. Reverse genetics is also an excellent way to associate genes with phenotypes, although an absence of detectable phenotypes often results when screening a small number of mutants with a limited range of phenotypic assays. The Arabidopsis Chloroplast 2010 Project (www.plastid.msu.edu) seeks synergy between forward and reverse genetics by screening thousands of sequence-indexed Arabidopsis (Arabidopsis thaliana) T-DNA insertion mutants for a diverse set of phenotypes. Results from this project are discussed that highlight the strengths and limitations of the approach. We describe the discovery of altered fatty acid desaturation phenotypes associated with mutants of At1g10310, previously described as a pterin aldehyde reductase in folate metabolism. Data are presented to show that growth, fatty acid, and chlorophyll fluorescence defects previously associated with antisense inhibition of synthesis of the family of acyl carrier proteins can be attributed to a single gene insertion in Acyl Carrier Protein4 (At4g25050). A variety of cautionary examples associated with the use of sequence-indexed T-DNA mutants are described, including the need to genotype all lines chosen for analysis (even when they number in the thousands) and the presence of tagged and untagged secondary mutations that can lead to the observed phenotypes.
Students’ clinical experience on outreach placements (2010)

Dental outreach training greatly increases the quantity of students' clinical experience in everyday dentistry compared to a hospital-based programme. Placements also increase awareness of service delivery and develop clinical skills. There are appreciable variations between outreach settings possibly reflecting their purposes. Multiple contrasting outreach placements for each student might increase the uniformity of learning experiences.
Analytical synthesis of low-sensitivity voltage-mode odd-nth-order OTA-C elliptic filter structure with the minimum number of components (2007)

Though the current-mode odd-nth-order operational transconductance amplifier and capacitor (OTA-C) elliptic filter structure with the minimum number of active and passive components was presented recently, yet none of its counterpart, the voltage-mode ones, have been reported. After a new analytical synthesis method, namely, an innovative algebraic decomposition of a complex nth-order transfer function into n simple and feasible equations, the voltage-mode odd-nth-order OTA-C elliptic filter structure with the minimum number of components is proposed in this paper. The Hspice simulation with 0.35μm process for a voltage-mode third-order OTA-C elliptic low-pass filter, employing only four OTAs and three grounded capacitors, validates not only precise filtering parameters but low sensitivity and low power consumption performances.
Butadiene Diepoxide Activation of Guanylate Cyclase (1978)

A variety of nitroso chemical carcinogens increase the activity of guanylate cyclase (EC 4.6.1.2), the enzyme catalyzing the production of guanosine 3',5'-monophosphate. In the present report, the first non-nitroso chemical carcinogen, butadiene diepoxide, was shown to activate guanylate in a variety of tissues over the concentration range 1—100 mmol/l. At 20 mmol/l concentration, increases were 2- to 17-fold above control. These observations have potential importance since guanosine 3',5'-monophosphate may be involved in cell growth and malignant transformation.
Sorafenib in Combination with Betulinic Acid Synergistically Induces Cell Cycle Arrest and Inhibits Clonogenic Activity in Pancreatic Ductal Adenocarcinoma Cells (2018)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers in the world due to late diagnosis and poor response to available treatments. It is important to identify treatment strategies that will increase the efficacy and reduce the toxicity of the currently used therapeutics. In this study, the PDAC cell lines AsPC-1, BxPC-3, and Capan-1 were treated with sorafenib and betulinic acid alone and in combination. We examined the effect of combined treatments on viability (MTS test), proliferation and apoptosis (annexin V staining), cell cycle arrest (PI staining), alterations in signaling pathways (Western blotting), and colony-forming ability. The combination of sorafenib with betulinic acid inhibited the viability and proliferation of PDAC cells without the induction of apoptosis. The antiproliferative effect, caused by G2 cell cycle arrest, was strongly associated with increased expression of p21 and decreased expression of c-Myc and cyclin D1, and was induced only by combined treatment. Additionally, decreased proliferation could also be associated with the inhibition of the P13K/Akt and MAPK signaling pathways. Importantly, combination treatment reduced the colony-forming ability of PDAC cells, as compared to both compounds alone. Collectively, we showed that combined treatment with low concentrations of sorafenib and betulinic acid had the capacity to inhibit proliferation and abolish clonogenic activity in PDAC cell lines.
Spongian pentacyclic diterpenes. Stereoselective synthesis of (-)-dendrillol-1 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpongian pentacyclic diterpenes. Stereoselective synthesis of (-)-dendrillol-1Antonio Abad, Manuel Arno, Ana C. Cunat, M. Luisa Marin, and Ramon J. ZaragozaCite this: J. Org. Chem. 1992, 57, 25, 6861–6869Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jo00051a035https://doi.org/10.1021/jo00051a035research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ligands of glutamate and dopamine receptors evenly labeled with hydrogen isotopes (2009)

A reaction of high-temperature solid-phase catalytic isotope exchange (HSCIE) was studied for the preparation of tritium- and deuterium-labeled ligands of glutamate and dopamine receptors. Tritium-labeled (5S,10R)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclopenten-5,10-imine ([G-(3)H]MK-801) and R(+)-7-hydroxy-N,N-di-n-propyl-2-aminotetraline ([G-(3)H]-7-OH-DPAT) were obtained with a specific activity of 210 and 120 Ci/mol, respectively. The isotopomeric distribution of deuterium-labeled ligands was studied using time-of-flight mass-spectrometer MX 5310 (ESI-o-TOF) with electrospray and orthogonal ion injection. Mean deuterium incorporation per ligand molecule was 11.09 and 3.21 atoms for [G-(2)H]MK-801 and [G-(2)H]-7-OH-DPAT, respectively. The isotope label was shown to be distributed all over the ligand molecule. The radioreceptor binding of tritium-labeled ligands [G-(3)H]MK-801 and [G-(3)H]-7-OH-DPAT was analyzed using the brain structure of Vistar rats. It was demonstrated that [G-(3)H]MK-801 specifically binds to hippocampus membranes with K(d) 8.3 +/- 1.4 nM, B(max) being 3345 +/- 300 fmol/mg protein. The [G-(3)H]-7-OH-DPAT ligand specifically binds to rat striatum membranes with K(d) 10.01 +/- 0.91 nM and B(max) 125 +/- 4.5 fmol/mg protein. It was concluded that the HSCIE reaction can be used for the preparation of highly tritium-labeled (+)-MK-801 and 7-OH-DPAT with retention of their physiological activities.