gebhart/patrepeval huggingface dataset:
An Improved Procedure for the Synthesis of Prostaglandin Analogues (1990)

Abstract Hydrozirconation-iodination of a terminal acetylene followed by lithium-iodide exchange and finally dilithio cyanocuprate mediated conjugate addition to an appropriate cyclopentenone is reported as an efficient method for the synthesis of prostaglandin analogues.
Synthesis, Cytotoxic Activity, Crystal Structure, DFT, Molecular Docking Study of β-Enaminonitrile Incorporating 1H-Benzo[f]Chromene Moiety (2022)

In this work, we used microwave irradiation conditions to synthesize β-enaminonitrile (4), which was affirmed using single crystal X-ray diffraction and the different spectral data. Two tumor cell lines, MCF-7 and MCF-7/ADR, as well as two normal cell lines, HFL-1 and WI-38, were used to assess the anticancer activity of compound 4. The studied molecule exhibited potent efficacy against the MCF-7 and MCF-7/ADR cell lines compared with the reference drugs. Furthermore, target compound 4 had feeble activity against HFL-1 and WI-38. The chemical reactivity was discussed using DFT and QTAIM analysis to study the intrinsic electronic properties of compound 4. A molecular docking study was also conducted to examine their binding affinity to the EGFR. Compound 4 revealed a stable binding mode at the enzyme active pocket more than the reference inhibitor. The docking analysis was performed for molecule (4).
Programa oficial de Ferias y Fiestas en honor de San Anastasio mártir patrón de la ciudad, Lérida mayo de 1975 (1975)

Textos: Jose A. Rosell Pujol ; fotografies: Rey Cascales i Sociedad Fotografica de Lerida ; maqueta: Manuel Talavera
Experimental setup for investigating blood flow measurement by microwave methods (2014)

This paper presents a setup and measurement results for the proof-of-concept study of the feasibility of measuring flow from heating and cooling thermal response upon applying microwave heating at 900 MHz. A temperature regulated bath/pump system and microwave heating apparatus are used. With respect to various water flow rates, distinct variations in terms of the temperature rise and fall time responses (measured at a depth of about 8 mm in water) versus the flow rate, and their steady-state levels, upon applying microwave heating, are observed. This method is of particular interest in non-invasive measurement of blood perfusion using microwave heating and radiometry. Further discussions in regard to the setup improvement and perfusion estimation from the thermal response measurements are provided.
A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells from the Entire Umbilical Cord (2016)

Several reports have been published on the isolation, culture, and identification of mesenchymal stem cells (MSCs) from different anatomical regions of the umbilical cord (UC). UC is suitable for standardizing methods of MSC isolation because it is a uniform source with high MSC numbers. Although the UC is considered a medical waste after childbirth, ethical issues for its use must be considered. An increased demand for MSCs in regenerative medicine has made scientists prioritize the development of MSC isolation methods. Several research groups are attempting to provide a large number of high-quality MSCs. In this study, we present a modulated explant/enzyme method (MEEM) to isolate the maximum number of MSCs from the entire UC. This method was established for the isolation of MSCs from different anatomical regions of the UC altogether. We could retrieve 6 to 10 million MSCs during 8 to 10 days of primary culture. After three passages, we could obtain 8–10 × 10 8 cells in 28–30 days. MSCs isolated by this method express CD73, CD90, CD105, and CD44, but they do not express hematopoietic markers CD34 and CD45 or the endothelial marker CD31. The genes SOX2, OCT4, and NANOG are expressed in isolated MSCs. The capacity of these MSCs to differentiate into adipocytes and osteocytes highlights their application in regenerative medicine. This method is simple, reproducible, and cost efficient. Moreover, this method is suitable for the production of a large number of high-quality MSCs from an UC in less than a month, to be used for cell therapy in an 80-kg person.
A thermoresponsive crosslinker for reversible micelle stabilization (2021)

Herein we report a thermoresponsive crosslinker that can be utilized to stabilize the surface of micelles through “click” reaction and to trigger the disassembly <italic>via</italic> retro Diels Alder (rDA) mechanism.
Comparison of Oral Omeprazole and Endoscopic Ethanol Injection Therapy for Prevention of Recurrent Bleeding From Peptic Ulcers With Nonbleeding Visible Vessels Or Fresh Adherent Clots (2002)

Oral omeprazole administration is comparable to endoscopic ethanol injection therapy for prevention of rebleeding in patients with nonbleeding visible vessels or adherent clots.
Systematic Review of Randomized Controlled Trials Comparing Manual Compression to Vascular Closure Devices for Diagnostic and Therapeutic Arterial Procedures. (2015)

Overall, the review of 34 RCTs demonstrates the utility of VCDs has shortened time to hemostasis, ambulation, and discharge compared to patients receiving MC. Over the last decade, with emphasis on and implementation of same-day procedures, use of VCDs has resulted in a reduction in time to discharge to half a day and a significant decrease in cost. Overall complication rates are similar, but vary between different devices on the market. Better short-term quality of life has also been described with the use of VCDs compared to MC. Further clinical and financial improvements may be found as newer technological advances of VCDs become available.
ChemInform Abstract: Acidities of Hydrocarbons and Sulfur‐Containing Hydrocarbons in Dimethyl Sulfoxide Solution. (1987)

Abstract Based on (IIa) the relative acidities of hydrocarbons such as (I) and (IIb), which form highly delocalized carbanions, agree well with their ion‐pair acidities measured in cyclohexylamine.
Phosphorylated Cellulose Nanofibrils: A Renewable Nanomaterial for the Preparation of Intrinsically Flame-Retardant Materials (2015)

Cellulose from wood fibers can be modified for use in flame-retardant composites as an alternative to halogen-based compounds. For this purpose, sulfite dissolving pulp fibers have been chemically modified by phosphorylation, and the resulting material has been used to prepare cellulose nanofibrils (CNF) that have a width of approximately 3 nm. The phosphorylation was achieved using (NH4)2HPO4 in the presence of urea, and the degree of substitution by phosphorus was determined by X-ray photoelectron spectroscopy, conductometric titration, and nuclear magnetic resonance spectroscopy. The presence of phosphate groups in the structure of CNF has been found to noticeably improve the flame retardancy of this material. The nanopaper sheets prepared from phosphorylated CNF showed self-extinguishing properties after consecutive applications of a methane flame for 3 s and did not ignite under a heat flux of 35 kW/m2, as shown by flammability and cone calorimetry measurements, respectively.
Droplet-induced optical resonator in a silica microcapillary (2018)

We show that light circulating in a silica microcapillary can be fully localized by evanescent coupling to a water droplet forming a high Q-factor microresonator. The discovered phenomenon suggests an advanced method for microfluidics sensing.
[Paper] Stabilization Effect of Self-Assembly Dendrimer Doped Cholesteric Liquid Crystal on Helical Structure (2021)

In this paper, we report the resettable functionality of helix pitch length in the mixture composed of cholesteric liquid crystal and self-assembly dendrimer with lysine groups. Cholesteric-phase liquid crystal was obtained by doping a tiny amount of dendrimer less than 0.01 wt% concentration. The mixture showed not only thermal stability of helix pitch length but also resettability of that by temperature control process based on sol-gel transition characteristics in the dendrimer with lysine group. We discuss the temperature effect of the proposed cholesteric liquid crystal on such unique functionality.
A mechanism of haloalkene-induced renal carcinogenesis. (1990)

Several halogenated alkenes are nephrotoxic; some others induce renal tubular adenocarcinomas in rodents after lifelong administration. A bioactivation mechanism accounting for the organ-selective tumor induction has been elucidated: conjugation of the parent compounds with glutathione (GSH), catalyzed by hepatic GSH S-transferases, results in the formation of haloalkyl and halovinyl glutathione S-conjugates. Formation of S-conjugates (identified by NMR and mass spectrometry) could be demonstrated with trichloroethene, tetrachloroethene, hexachlorobutadiene, perfluoropropene, trichlorotrifluoropropene, and dichloroacetylene in incubations with rat liver microsomes and in the isolated perfused rat liver. The GSH conjugates formed are eliminated from the rat liver with the bile and may be translocated to the kidney, intact or after metabolism to the corresponding cysteine S-conjugates that are metabolized in the kidney by renal tubular cysteine conjugate beta-lyase (beta-lyase) to reactive intermediates, most likely thioacylchlorides and thioketenes. Interaction of these potent electrophiles with DNA [demonstrated for intermediates formed from S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine] causes mutagenicity in bacteria, genotoxicity in cultured renal cells, and cytotoxicity in kidney cells. As an alternative to beta-lyase-catalyzed cleavage, the cysteine S-conjugates may be acetylated to the corresponding mercapturic acids, which have been identified in urine. The ability of the kidney to concentrate GSH and cysteine S-conjugates and the intensive metabolism of GSH S-conjugates to cysteine S-conjugates in this organ are evidently responsible for the organotropic carcinogenicity.
A Brute-Force CNN Model Selection for Accurate Classification of Sensorimotor Rhythms in BCIs (2020)

The ultimate goal of Brain-Computer Interface (BCI) research is to enable individuals to interact with their environment by translating their mental imagery. In this regard, a salient issue is the identification of brain activity patterns that can be used to classify intention. Using Electroencephalographic (EEG) signals as archetypical, this classification problem generally possesses two stages: (i) extracting features from collected EEG waveforms; and (ii) constructing a classifier using extracted features. With the advent of deep learning, however, the former stage is generally absorbed into the latter. Nevertheless, the burden has now shifted from trying a number of feature extraction methods to tuning a large number of hyperparameters and architectures. Among existing deep learning architectures used in BCI, Convolutional Neural Networks (CNN) have become an attractive choice. Most of the existing studies that use these networks are based on well-known architectures such as AlexNet or ResNet, use the domain knowledge to construct the final architecture or have an unclear strategy deployed for model selection. This raises the question as to whether constructing accurate CNN-based classifiers is possible using a principled model selection, with the most straightforward one being the brute-force search or, alternatively, experience and developing high intuition regarding hyperparameters combined with an ad hoc approach is the most prudent way to go about designing them. To this end, in this paper, we first define a space of hyperparameters restricted by our computing power. Then we show that an exhaustive search within this limited space of CNN hyperparameters leads to accurate classification of sensorimotor rhythms that arise during motor imagery tasks.
Initial membrane reaction in the biosynthesis of peptidoglycan. Spin-labeled intermediates as receptors for vancomycin and ristocetin (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInitial membrane reaction in the biosynthesis of peptidoglycan. Spin-labeled intermediates as receptors for vancomycin and ristocetinLaurance S. Johnston and Francis C. NeuhausCite this: Biochemistry 1975, 14, 12, 2754–2760Publication Date (Print):June 17, 1975Publication History Published online1 May 2002Published inissue 17 June 1975https://pubs.acs.org/doi/10.1021/bi00683a031https://doi.org/10.1021/bi00683a031research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced Interpretation of Diagnostic Images (1988)

In radiology, as in various other fields, observers study images to detect and diagnose underlying conditions. They make assessments of several image features and merge them into an overall decision. Demonstration is given here, in the context of mammography, that objective aids to this interpretative process can substantially improve accuracy, even for sophisticated and motivated radiologists. The aids are a checklist that solicits explicit, quantitative, systematic assessments of the important features of an image and a computer program that merges those assessments with optimal weights. The computer issues estimates of the likelihoods that specified conditions are present (in this study, the likelihood that a localized abnormality is malignant), and the radiologist benefits from taking those estimates as guidance.
Smell Identification Using a Thick-Film Hybrid Gas Sensor (1987)

An analytical method and experimental results of identifying and quantifying smells using an electronic system composed of an integrated sensor and a microcomputer are described. The integrated sensor with six different elements on an alumina substrate was fabricated by using thick-film techniques. The elements are kept at around 400°C by a Pt heater mounted on the sensor back. Since each element was made from different semiconductor oxides, they possess different sensitivities to material odors and the integrated sensor can develop specific patterns corresponding to each odor as a histogram of conductance ratios for each element. The microcomputer identifies the scent on the basis of similarities calculated by comparing standard patterns stored in the memory and a sample pattern developed by the integrated sensor. The scent is then quantified by using the sensor element with the highest sensitivity to the smell identified. The experimental results show that smells can be successfully identified and quantified with the electronic System.
Switched-capacitor circuit techniques in submicron low-voltage CMOS (2003)

The continued down scaling of submicron CMOS technology forces innovation of practical and economical circuits that will tolerate reduced headroom (reduced power supply voltage) due to lowering of the technology's maximum allowable voltage. Given the relatively large threshold voltages with respect to the shrinking headroom, a group of widely used analog signal processing building blocks that are made of switched-capacitor (SC) stages will encounter severe overdrive problems when operating at these low-voltage conditions. This tutorial summarizes some of the well-known solutions currently in use and problems associated with these solutions, and proposes novel circuit techniques for truly low-voltage switched-capacitor applications.
Vibrational-mode shifts in inelastic electron tunneling spectroscopy: Effects due to superconductivity and surface interactions (1976)

Measurements of the effect of the top metal electrode on the vibrational-mode energies of benzoic acid on aluminum oxide with Pb, Sn, and Ag top metal electrodes are described. Peak shifts of approximately 15 meV for the O-H stretch modes of hydroxyl ions, 0.5 meV for the C-H bending modes, and less than 0.2 meV for the C-C ring stretch and bend modes of benzoate molecules were found. These measurements are discussed in terms of a simple image model. For junctions with superconducting electrodes a modulation-dependent correction must be made to the measured peak positions. A theory is developed for the line shapes and peak positions of both the second and third harmonic signals and compared with experiment.
N-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS (2019)

Glycosylation influences the structure and functionality of glycoproteins, and is regulated by genetic and environmental factors. The types and abundance of glycans on glycoproteins can vary due to diseases such as cancer, inflammation, autoimmune and neurodegenerative disorders. Due to the crucial role glycans play in modulating protein function, glycosylation analysis could lead to the discovery of novel biomarkers and is of prime importance in controlling the quality of glycoprotein biopharmaceuticals. Here, we present a method for the identification and quantification of glycoforms directly on intact proteins, after immunoaffinity purification from biological fluids. The method was validated and applied to serum transferrin and the biopharmaceutical trastuzumab. The accuracy of the method, expressed as the relative error (RE), ranged from 2.1 (at high concentrations) to 7.9% (at low concentrations), and intra- and inter-day precision, expressed as relative standard deviation (RSD), was 3.2 and 8.2%, respectively. The sensitivity and linearity of the method were suitable for serum analysis and the LOQ was calculated to be 3.1 and 4.4 μg mL-1 for transferrin (TFN) and trastuzumab (TRA), respectively. Its application to transferrin from five healthy human serum samples yielded concentrations between 1.61 and 3.17 mg mL-1, which are in agreement with blood reference levels. In parallel, the structure of the identified glycans was determined by ion mobility spectrometry coupled with tandem mass spectrometry. No chromatographic separation was required and sample preparation was performed in a semi-automatic manner, facilitating the handling of up to 12 samples at a time. This method should be useful for clinical laboratories and for the quality control of large batches of biopharmaceuticals.
Improving mechanical properties of carbon nanotube fibers through simultaneous solid-state cycloaddition and crosslinking (2017)

Individual carbon nanotubes (CNTs) exhibit exceptional mechanical properties. However, difficulties remain in fully realizing these properties in CNT macro-assemblies, because the weak inter-tube forces result in the CNTs sliding past one another. Herein, a simple solid-state reaction is presented that enhances the mechanical properties of carbon nanotube fibers (CNTFs) through simultaneous covalent functionalization and crosslinking. This is the first chemical crosslinking proposed without the involvement of a catalyst or byproducts. The specific tensile strength of CNTFs obtained from the treatment employing a benzocyclobutene-based polymer is improved by 40%. Such improvement can be attributed to a reduced number of voids, impregnation of the polymer, and the formation of covalent crosslinks. This methodology is confirmed using both multiwalled nanotube (MWNT) powders and CNTFs. Thermogravimetric analysis, differential scanning calorimetry, x-ray photoelectron spectroscopy, and transmission electron microscopy of the treated MWNT powders confirm the covalent functionalization and formation of inter-tube crosslinks. This simple one-step reaction can be applied to industrial-scale production of high-strength CNTFs.
Healthy Behavior Change of Adults With Mental Retardation: Attendance in a Health Promotion Program (2005)

Participation in a health promotion program for 192 overweight and obese adults with mental retardation was associated with behavior change resulting in reduction of body mass index-BMI (weight in kg, divided by height in meters, squared) by the end of the program. We analyzed the mediating and intermediate factors contributing to weight reduction and found knowledge and exercise to be the primary contributing factors. The curriculum emphasized exercise, nutritional choices, and stress reduction. Participation in the program was associated with a reduction of 0.8 BMI or approximately 2.3 kg for 26% of the participants. Increased knowledge about healthy diet and exercise was the most significant mediator of program impact on BMI.
Le professeur Camille Brunotte honoré à Arches, sa bourgade natale, dans le département des Vosges (2014)

Labrude Pierre. Le professeur Camille Brunotte honoré à Arches, sa bourgade natale, dans le département des Vosges. In: Revue d'histoire de la pharmacie, 101e année, N. 382, 2014. pp. 251-252.
Photonic crystals for light trapping within organic solar cells (2009)

We propose a methodology allowing the design of the active layer of organic solar cells in the shape of a photonic crystal. An optimised photonic crystal allows trapping the light in a layer at specific wavelengths thanks to a coupling of a low group velocity mode called slow Bloch mode. This method is used to design two structures which allow to improve absorption of light in organic solar cells for wavelengths close to the band gap of an active layer composed of poly-3-hexylthiophène (P3HT) and [6,6]-phenyl-C61-butiryc acid methyl ester (PCBM). Nevertheless, while the first structure does not allow an efficient charges harvesting by the electrodes, the second structure can be beneficial for both the optical and the electrical properties of the cell thanks to the structuring of the Poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) layer.
Long-term safety and efficacy of apomorphine infusion in Parkinson's disease patients with persistent motor fluctuations: Results of the open-label phase of the TOLEDO study (2021)

The safety and efficacy of APO infusion were demonstrated with long-term use for persistent motor fluctuations, allowing substantial reductions in oral PD medication.
Accurate RFID localization algorithm with particle swarm optimization based on reference tags (2016)

RFID technology has been widely used for object tracking in indoor environment due to their low cost and convenience for deployment. Existing RFID localization approaches rely on signal strength to measure the distance between RFID reader and tags. However, because of the environmental complexity and inferences, the measurement of distance by signal strength is not accurate, which causes large error in localization. In this paper we develop a novel algorithm to improve the RFID localization accuracy. Our algorithm is based on particle swarm optimization. More importantly, we add reference tags in the deployment, and design a parameter named Correction Factor in PSO to measure the distances more accurately by signal strength. The result shows that compared with the previous method without the correction factor, our proposed approach can increase the accuracy by 50%. This method has good application prospect in equipment management.
Xeroderma Pigmentosum: Spinal Cord Astrocytoma with 9-Year Survival after Radiation and Isotretinoin Therapy (1998)

In contrast to the exaggerated sensitivity to UV radiation, XP patients may tolerate therapeutic doses of x-radiation. Isotretinoin treatment may have contributed to the good response of this spinal cord astrocytoma.