gebhart/patrepeval huggingface dataset:
Integrity of the Saccharomyces cerevisiae Rpn11 Protein Is Critical for Formation of Proteasome Storage Granules (PSG) and Survival in Stationary Phase (2013)

Decline of proteasome activity has been reported in mammals, flies and yeasts during aging. In the yeast Saccharomyces cerevisiae, the reduction of proteolysis in stationary phase is correlated with disassembly of the 26S proteasomes into their 20S and 19S subcomplexes. However a recent report showed that upon entry into the stationary phase, proteasome subunits massively re-localize from the nucleus into mobile cytoplasmic structures called proteasome storage granules (PSGs). Whether proteasome subunits in PSG are assembled into active complexes remains an open question that we addressed in the present study. We showed that a particular mutant of the RPN11 gene (rpn11-m1), encoding a proteasome lid subunit already known to exhibit proteasome assembly/stability defect in vitro, is unable to form PSGs and displays a reduced viability in stationary phase. Full restoration of long-term survival and PSG formation in rpn11-m1 cells can be achieved by the expression in trans of the last 45 amino acids of the C-terminal domain of Rpn11, which was moreover found to co-localize with PSGs. In addition, another rpn11 mutant leading to seven amino acids change in the Rpn11 C-terminal domain, which exhibits assembled-26S proteasomes, is able to form PSGs but with a delay compared to the wild type situation. Altogether, our findings indicate that PSGs are formed of fully assembled 26S proteasomes and suggest a critical role for the Rpn11 protein in this process.
A Novel Semi-supervised SVM Based on Tri-training for Intrusition Detection (2010)

One of the main difficulties in machine learning is how to solve large-scale problems effectively, and the labeled data are limited and fairly expensive to obtain. In this paper a new semi-supervised SVM algorithm is proposed. It applies tri-training to improve SVM. The semi- supervised SVM makes use of the large number of unlabeled data to modify the classifiers iteratively. Although tri-training doesn't put any constraints on the classifier, the proposed method uses three different SVMs as the classification algorithm. Experiments on UCI datasets and application to the intrusion anomaly detection show that tri- training can improve the classification accuracy of SVM and its improved algorithms. We also find the accuracy of final classifier will be higher by increasing the difference of classifiers. Theoretical analysis and experiments show that the proposed method has excellent accuracy and classification speed.
Paired emitter–detector diode detection with dual wavelength monitoring for enhanced sensitivity to transition metals in ion chromatography with post-column reaction (2008)

The combination of post-column derivatisation and visible detection are regularly employed in ion chromatography (IC) to detect poorly absorbing species. Although this mode is often highly sensitive, one disadvantage is the increase in repeating baseline artifacts associated with out-of-sync pumping systems. The work presented here will demonstrate the use of a second generation design paired emitter-detector diode (PEDD-II) detection mode offering enhanced sensitivity to transition metals in IC by markedly reducing this problem and also by improving signal noise. First generation designs demonstrated the use of a single integrated PEDD detector cell as a simple, small (15 x 5 mm), highly sensitive, low cost photometric detector for the detection of metals in IC. The basic principle of this detection mode lies in the employment of two linear light emitting diodes (LEDs), one operating in normal mode as a light source and the other in reverse bias serving as a light detector. The second generation PEDD-II design showed increased sensitivity for Mn(II)- and Co(II)-2-(pyridylazo)resorcinol (PAR) complexes as a result of two simultaneously acquiring detection cells--one analytical PEDD cell and one reference PEDD cell. Therefore, the PEDD-II employs two wavelengths whereby one monitors the analyte reaction product and the second monitors a wavelength close to the isosbestic point. The optimum LED wavelength to be used for the analytical cell was investigated to maximise peak response. The fabrication process for both the analytical and reference PEDD cells was validated by determining the reproducibility of detectors within a batch. The reproducibility and sensitivity of the PEDD-II detector was then investigated using signals obtained from both intra- and inter-day chromatograms.
Resolution Limits of Non-Adaptive 20 Questions Estimation for Multiple Targets (2021)

We study the problem of simultaneous search for multiple targets over a multidimensional unit cube and derive the fundamental resolution limit of non-adaptive querying procedures using the 20 questions estimation framework. The performance criterion that we consider is the achievable resolution, which is defined as the maximal <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$L$</tex> <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</inf> norm between the location vector and its estimated version where the maximization is over the possible location vectors of all targets. The fundamental resolution limit is then defined as the minimal achievable resolution of any nonadaptive query procedure. We drive the second-order asymptotic bound on the minimal achievable resolution by relating the current problem to a data transmission problem over a multiple access channel, using the information spectrum by Han and borrowing results from finite blocklength information theory for random access channel coding. Our results extend the purely first-order asymptotic analyses of Kaspi et al. (ISIT 2015) for the one-dimensional case. Specifically, we consider more general channels, derive the second-order asymptotic result and establish a phase transition phenomenon.
LP CO<sub>2</sub> Compressor Final Technical Report (2018)

This report summarizes work performed by Dresser-Rand, A Siemens Business and subcontractors, under DOE award number DE-FE0026727, in pursuit of the design, construction and test of a 10:1 pressure ratio “Low Pressure” (LP) supersonic CO2 compressor suitable for use as a first stage in a two stage 100:1 compression system. This LP compressor, in conjunction with a corresponding 10:1 high pressure compressor, provide the overall 100:1 compression ratio required to compress CO2 from 22 psia (as generated by a CO2 capture system) to the 2215 psia required to transport CO2 via a pipeline to a suitable sequestration site. The compressor demonstrates application of Dresser-Rand’s supersonic compression technology at an industrial scale using CO2 in a closed-loop testing facility. This scope of this technical report is to summarize all phases of the program executed from August 5, 2015 to the June 30, 2018. This program included the final testing of a “high pressure” (HP) compressor that had previously been built by Dresser-Rand and the design, fabrication, assembly and test of a corresponding LP compressor. In summary, the LP compressor exceeded the target pressure ratio and efficiency goals for the program at CO2 flowrates suitable for those expected in coal fired power plant carbon capture systems. Initial and Final Techno-Economic Analysis reports were generated to show the value this compression solution brings to carbon capture and sequestration (CC&S) systems for the Case B12B coal fired power plant model. Integration of the DATUM S compression technology into a carbon capture and sequestration system was shown to result in a 27% reduction in the Cost of Electricity for the compression system, as well as a 21,500 gallon per hour reduction in required cooling water flow for the plant.
Antifibrinolytic therapy in the management of the kasabach merritt syndrome (1988)

The Kasabach Merritt syndrome consists of thrombocytopenia, microangiopathic hemolytic anemia, and a localized consumption coagulopathy that develops within the abnormal vascular channels of a hemangioma. In general, these patients demonstrate only mild abnormalities of screening clotting tests, but they can potentially develop life-threatening complications. We present a patient who developed a severe anemia that was refractory to erythrocyte transfusions. Treatment with epsilon-aminocaproic acid to inhibit fibrinolysis and cryoprecipitate to replenish his deficient circulating fibrinogen interrupted the cycle of his systemic coagulopathy and enabled us to transfuse him to a normal hematocrit.
Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab (2015)

Treatment with ipilimumab improves overall survival (OS) in patients with metastatic melanoma. Because ipilimumab targets T lymphocytes and not the tumor itself, efficacy may be uniquely sensitive to immunomodulatory factors present at the time of treatment. We analyzed serum from patients with metastatic melanoma (247 of 273, 90.4%) randomly assigned to receive ipilimumab or gp100 peptide vaccine. We quantified candidate biomarkers at baseline and assessed the association of each using multivariate analyses. Results were confirmed in an independent cohort of similar patients (48 of 52, 92.3%) treated with ipilimumab. After controlling for baseline covariates, elevated chemokine (C-X-C motif) ligand 11 (CXCL11) and soluble MHC class I polypeptide-related chain A (sMICA) were associated with poor OS in ipilimumab-treated patients [log10 CXCL11: HR, 1.88; 95% confidence interval (CI), 1.14-3.12; P = 0.014; and log10 sMICA quadratic effect P = 0.066; sMICA (≥ 247 vs. 247): HR, 1.75; 95% CI, 1.02-3.01]. Multivariate analysis of an independent ipilimumab-treated cohort confirmed the association between log10 CXCL11 and OS (HR, 3.18; 95% CI, 1.13-8.95; P = 0.029), whereas sMICA was less strongly associated with OS [log10 sMICA quadratic effect P = 0.16; sMICA (≥ 247 vs. 247): HR, 1.48; 95% CI, 0.67-3.27]. High baseline CXCL11 and sMICA were associated with poor OS in patients with metastatic melanoma after ipilimumab treatment but not vaccine treatment. Thus, pretreatment CXCL11 and sMICA may represent predictors of survival benefit after ipilimumab treatment as well as therapeutic targets.
NiO/ZnO p–n heterostructures and their gas sensing properties for reduced operating temperature (2016)

The operating temperature of ZnO-based gas sensors has been decreased, which is attributed to the formation of NiO/ZnO p–n heterostructures.
A sample preparation for quantitative determination of magnesium in individual lymphocytes by electron probe X‐ray microanalysis (1986)

We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +/- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +/- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of variation for both methods of analysis and a 30% coefficient of variation in magnesium concentration among individual cells by electron probe X-ray microanalysis. We wash cells in ammonium nitrate for microanalysis or in buffered saline glucose for atomic absorption analysis. We find cells washed in either solution have the same cell viability (85%), recovery (75%), cell volume (555 microns 3) and cytology. We air dry cells on thin film supports and show by magnesium X-ray mapping that magnesium is within the cells. We conclude that: our microanalysis cell preparation method preserves whole intact lymphocytes; there is no systematic difference in results from the two methods of analysis; electron probe X-ray microanalysis can determine the variation in magnesium concentration among individual cells.
ChemInform Abstract: Metal‐Exchanged Zeolites as Catalysts (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hydrodynamically Driven Self‐Assembly of Giant Vesicles of Metal Nanoparticles for Remote‐Controlled Release (2013)

The hydrodynamics of laminar flow in a microfluidic device has been used to control the continuous self-assembly of gold nanoparticles (NPs) tethered with amphiphilic block copolymers. Spherical micelles, giant vesicles (500 nm–2.0 μm), or disk-like micelles could be formed by varying the flow rates of fluids. Such vesicles can release encapsulated hydrophilic species by using near-IR light (see picture). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
AN ASYMMETRIC SYNTHESIS OF α-BENZYLOXY ALDEHYDES HAVING A CHIRAL TERTIARY CENTER—AN APPLICATION TO THE ASYMMETRIC SYNTHESIS OF exo-(+)-BREVICOMIN— (1983)

Abstract α-Benzyloxy aldehydes having a chiral tertiary center at α-carbon atom are synthesized in high enantiomeric excess by successive treatment of 2-methoxycarbonyl-3-phenyl-1,3-diazabicyclo[3.3.0]octane with diisobutylaluminum hydride (DIBAL-H) and Grignard reagents. The asymmetric reaction is applied to the total synthesis of exo-(+)-brevicomin.
Linear Accelerators for Radiation Therapy (2017)

Linear Accelerators for Radiation Therapy, Second Edition focuses on the fundamentals of accelerator systems, explaining the underlying physics and the different features of these systems. This edition includes expanded sections on the treatment head, on x-ray production via multileaf and dynamic collimation for the production of wedged and other intensity modulated beams, on electron scattering systems, and on dosimetry. With high-quality illustrations and practical examples throughout, it contains a detailed description of electron beam optics and linear accelerator components. The final chapter explains how to use other equipment, such as scanners and simulators, in conjunction with linear accelerators for optimum treatment of cancers.
ESTUDIO AEROBIOLÓGICO DE LA CIUDAD DE SALAMANCA DURANTE EL AÑO 2000 (2003)

RESUMEN: Se ha realizado el analisis del polen presente en la atmosfera de la ciudad deSalamanca durante el ano 2000, en el que existe un descenso de 3oC en la temperaturamedia del mes de enero y elevadas precipitaciones en abril y mayo, contrastando convalores debiles en enero y febrero. De los 43 taxa identificados, destacar las gramineas conun numero total anual de 2.765 granos, como mas abundantes, seguido de Quercus , con1982. Tambien importantes en cuanto a frecuencia y abundancia son las cupresaceas querepresentan el polen mas destacable dentro de la Flora ornamental. Por ultimo senalar a lasurticaceas y Plantago , presentes en la atmosfera en 25 y 19 semanas, respectivamente, delano estudiado.PALABRAS CLAVE: Aerobiologia, Polen, Salamanca.SUMMARY: We have carried out an analysis of the pollen present in the atmosphere ofSalamanca City during the year 2000, with a decrease of 3°C average temperature inJanuary, and copious rainfalls in April and May, contrasting with lower values in Januaryand February. Among 43 taxa identified, we remark poaceae pollen, which was the mostabundant, with a total amount of 2.765 grains; followed by
Immobilization of highly-dispersed single-walled carbon nanotubes in biocompatible and water-soluble solid matrix (2008)

Purified HiPco SWNTs were dispersed in lactose aqueous solutions containing sodium deoxycholate (SDC) as the dispersant, with the assistance of ultrasonication. After removing the large bundles of SWNT by high speed centrifugation, the resulted SWNTs aqueous dispersion was spray-dried, and then the SWNTs-lactose solid dispersions (or composite particles) were obtained. They were mostly of spherically shell-structured shape with several microns in diameter. Vis-NIR spectroscopy and TEM observation revealed that SWNTs presented as small bundles and individual tubes inside the lactose solid matrix. These results indicate that lactose precipitated out from the aqueous droplets in the spray-drying, and transformed to solid matrix rapidly, which prevented the dispersed SWNTs from re-aggregation, thus immobilize the isolated SWNTs inside the matrix. The present solid dispersions can readily be re-dispersed in water and form SWNTs aqueous dispersion.
Adenovirus-Mediated Gene Transfer to Normal and Atherosclerotic Arteries (1995)

Previous studies of gene transfer to blood vessels in vivo have relied on intraluminal, catheter-based methods for delivery of adenoviral and other vectors. In this study, topical application of a replication-deficient adenoviral vector was used as an alternative method of gene transfer to the vessel wall. We administered recombinant adenovirus (1.0 x 1.5 x 10(10) pfu/mL) containing the nuclear targeted bacterial beta-galactosidase gene topically to arteries in normal and atherosclerotic cynomolgus monkeys. Topical administration was achieved by injection of adenoviral suspension within the periarterial sheath. Segments of femoral and carotid arteries were examined histochemically after staining with 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside 1 day after treatment with the adenovirus. After topical administration of virus, beta-galactosidase activity was observed in approximately 20% of cells in the adventitia in both normal and atherosclerotic arteries. There was no detectable beta-galactosidase activity in cells of the intima or media. Thus, topical application provides an alternative method for gene transfer to blood vessels in vivo. This approach, which does not require interruption of blood flow and does not disrupt the endothelium, may be useful for studies of vascular biology and perhaps gene therapy in both normal and atherosclerotic vessels.
An Overlay Architecture for Managing Lightpaths in Optically Routed Networks (2005)

Existing solutions for optically routed networks (ORNs) lack certain key management functions available to electronically routed networks. In particular, ORNs have extremely limited capabilities to trace the path of an optical signal through the network. In this paper, we present a method for embedding path identification and other management information into the transport stream in such a way that the management information can be read by a low-bandwidth, low-cost receiver, without having to terminate or decode the full-rate payload stream. We outline a method for embedding such management information, using a digital coding process at the transmitter, and two distinct digital decoding processes for receiving the management and payload data streams, respectively. Feasibility of the method is demonstrated by computing the bit-error performance of example codes under realistic operating conditions, including multiple management streams in multiwavelength systems.
HUMAN NATURAL ANTIBODIES TO PORCINE PLATELETS (1994)

The specificity of human natural antibodies directed against blood cells from pigs was investigated by ELISA and immunoblotting. Both IgG and IgM were identified as xenoantibodies reacting with pig platelets adsorbed to microplates. The antibodies could be absorbed on platelets as well as on RBC, suggesting that the corresponding antigens are expressed on the surface of a variety of cells. Galactose (20 mM) and melibiose (10 mM) partially inhibited (approximately 50%) the binding of antibodies to platelets, whereas lactose and cellobiose (300 mM) did not. On immunoblots, platelet glycoproteins of 115,125,135,180, and 210 kDa were specifically revealed with human sera diluted 1/20. In contrast with the results obtained by ELISA, xenoantibodies reactive with blotted glycoproteins were of the IgM class and the binding was not significantly inhibited by galactose or melibiose. “Anti-Gal” antibodies, purified from human sera by affinity chromatography on a melibiose-Sepharose immunoabsorbent, represented only a minor portion of the antibodies reactive with porcine platelets. Purified anti-Gal antibodies bound to the 115− and 135-kDa components, whereas the antibodies in the nonre-tained fraction revealed the 125-kDa molecule. As deduced from these data, human serum contains natural antibodies of both IgG and IgM classes directed to several porcine antigens. Gal-reactive structures were identified on the 115− and 135-kDa platelet glycoproteins, which might be homologous to their counterpart on endothelial cells. Also, the present work suggests that a majority of the natural antibodies reacted with other unidentified structures.
Study of higher mass charm baryons decaying to Λ+ (1996)

We report on the study of charm baryons decaying to Λc+: Λc★+(2625) → Λc+π+π−, Λc★+(2593) → Λc+π+π−, Σc0 → Λc+π− and Σc++ → Λc+π+. We present a confirmation of the state Λc∗+ (2593) and determine its mass difference to be M(Λc★+(2593)) − M(Λc+) = 309.2 ± 0.7 ± 0.3 MeV/c2. We determine the lower limit on the resonant branching ratio to be BR(Λc★+(2593) → Σcπ±Λc★+(2593) → Λc+π+π−) > 0.51 (90% c.l.). We also measure the mass differences M(Σc0) − M(Λc+) = 166.6±0.5±0.6 MeV/c2 and M(Σc++) − M(Λc+) = 167.6±0.6±0.6 MeV/c2. Finally, we measure the relative photoproduction cross sections for Λc★+ and Σc with respect to the (inclusive) photoproduction cross section for Λc+.
The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis (2021)

Annual screening in Black men is expected to reduce mortality more than that estimated under historical screening. Limiting screening to men younger than 70 years is expected to help reduce overdiagnosis.
First domestic comparison of ball plate calibration in Japan (2005)

Ball plates have been increasingly used for checking the performance of coordinate measuring machines (CMMs) in Japan. In future, the ball plate will become a popular gauge for checking or calibrating the CMM in Japan. Currently, only the National Metrology Institute of Japan (NMIJ) can calibrate the ball plate in Japan. There are no other institutes or calibration laboratories able to calibrate the ball plate. Therefore, we organized a ball plate round-robin measurement to create the opportunity to relay our calibration technique to other institutes. This is the first domestic comparison of a ball plate calibration in Japan. Sixteen institutes including NMIJ participated in the comparison. In this round-robin measurement, we formed two groups and supplied two ball plates (KOBA 420×420 mm, RETTER 420×420 mm) and two material standards of length made by NMIJ for this round-robin measurement. The round-robin measurement took place from October 2003 to September 2004. We describe the results of the comparison in this paper.