gebhart/patrepeval huggingface dataset:
Dissociation of alpha beta DNA polymerase of avian myeloblastosis virus by dimethyl sulfoxide (1976)

The alpha beta DNA polymerase of avian myeloblastosis virus was treated with dimethyl sulfoxide to dissociate the enzyme subunits. The dimethyl sulfoxide treated enzymes were passed over phosphocellulose to purify and characterize the dissociated subunits as well as to remove the dimethyl sulfoxide. RNA-directed DNA polymerase, RNase H, and nucleic acid-binding activity were monitored, as well as the subunit structure (on sodium dodecyl sulfate-polyacrylamide gels) of the various enzyme species obtained. With 30% dimethyl sulfoxide, the majority of DNA polymerase and RNase H activities as well as the alpha subunit were displaced from the alpha beta DNA polymerase position on phosphocellulose (0.23 M potassium phosphate) to the alpha DNA polymerase position (0.1 M). The association of DNA polymerase and RNase H activities with the alpha subunit suggests that alpha is the enzymatically active subunit in alpha beta. In addition to alpha DNA polymerase, a minor polymerase species eluted from phosphocellulose at 0.4 M potassium phosphate. The dissociated beta subunit eluted from phosphocellulose at a wide range of salt concentrations (0.28 to 0.5 M potassium phosphate). The dissociated beta subunit bound 3H-labeled murine leukemia virus RNA and [3H]poly(dT)-poly(dA) approximately 20-fold more avidly than alpha DNA polymerase alone. In contrast to the results with the alpha subunit, there was no correlation between DNA polymerase and RNase H activity profiles and the elution profile of the beta subunit from phosphocellulose. These observations suggest the beta subunit is either enzymatically inactive or possesses limited DNA polymerase and RNase H activity when compared with the alpha subunit.
Mixed-Criticality Task Synchronization in Zero-Slack Scheduling (2011)

Recent years have seen an increasing interest in the scheduling of mixed-criticality real-time systems. These systems are composed of groups of tasks with different levels of criticality deployed over the same processor(s). Such systems must be able to accommodate additional execution-time requirements that may occasionally be needed. When overload conditions develop, critical tasks must still meet their timing constraints at the expense of less critical tasks. Zero-slack scheduling algorithms are promising candidates for such systems. These algorithms guarantee that all tasks meet their deadlines when no overload occurs, and that criticality ordering is satisfied under overloads. Unfortunately, when mutually exclusive resources are shared across tasks, these guarantees are voided. Furthermore, the dual-execution modes of tasks in mixed-criticality systems violate the assumptions of traditional real-time synchronization protocols like PCP and hence the latter cannot be used directly. In this paper, we develop extensions to real-time synchronization protocols (Priority Inheritance and Priority Ceiling Protocol) that coordinate the mode changes of the zero-slack scheduler. We analyze the properties of these new protocols and the blocking terms they introduce. We maintain the deadlock avoidance property of our PCP extension, called the Priority and Criticality Ceiling Protocol (PCCP), and limit the blocking to only one critical section for each of the zero-slack scheduling execution modes. We also develop techniques to accommodate the blocking terms arising from synchronization, in calculating the zero-slack instants used by the scheduler. Finally, we conduct an experimental evaluation of PCCP. Our evaluation shows that PCCP is able to take advantage of the capacity of zero-slack schedulers to reclaim unused over-provisioning of resources that are only used in critical execution modes. This allows PCCP to accommodate larger blocking terms.
DETECTION OF NATURALLY OCCURRING OSTEOSARCOMA IN DOG WITH RADIOIODINATED FAB2 FRAGMENT OF MONOCLONAL ANTIBODY (1991)

S of the Society of Nuclear Medicine in Canada and Prairie Provinces Chapter, SNM Conjoint Meeting: PDF Only
Activating Organic Phosphorescence via Heavy Metal–π Interaction Induced Intersystem Crossing (2022)

Heavy-atom-containing clusters, nanocrystals, and other semiconductors can sensitize the triplet states of their surface-bonded chromophores, but the energy loss, such as nonradiative deactivation, often prevents the synergistic light emission in their solid-state coassemblies. Cocrystallization allows new combinations of molecules with complementary properties for achieving functionalities not available in single components. Here, the cocrystal formation that employs platinum(II) acetylacetonate (Pt(acac)<sub>2</sub> ) as a triplet sensitizer and electron-deficient 1,4,5,8-naphthalene diimides (NDIs) as organic phosphors is reported. The hybrid cocrystals exhibit room-temperature phosphorescence confined in the low-lying, long-lived triplet state of NDIs with photoluminescence (PL) quantum yield (Φ<sub>PL</sub> ) exceeding 25% and a phosphorescence lifetime (τ<sub>Ph</sub> ) of 156 µs. This remarkable PL property benefits from the noncovalent electronic and spin-orbital coupling between the constituents.
Size-controlled one-pot synthesis of fluorescent cadmium sulfide semiconductor nanoparticles in an apoferritin cavity (2008)

A simple size-controlled synthesis of cadmium sulfide (CdS) nanoparticle (NP) cores in the cavity of apoferritin from horse spleen (HsAFr) was performed by a slow chemical reaction synthesis and a two-step synthesis protocol. We found that the CdS NP core synthesis was slow and that premature CdS NP cores were formed in the apoferritin cavity when the concentration of ammonia water was low. It was proven that the control of the ammonia water concentration can govern the CdS NP core synthesis and successfully produce size-controlled CdS NP cores with diameters from 4.7 to 7.1 nm with narrow size dispersion. X-ray powder diffraction (XRD), energy dispersive spectroscopy (EDS) analysis and high-resolution transmission electron microscopy (HR-TEM) observation characterized the CdS NP cores obtained as cubic polycrystalline NPs, which showed photoluminescence with red shifts depending on their diameters. From the research of CdS NP core synthesis in the recombinant apoferritins, the zeta potential of apoferritin is important for the biomineralization of CdS NP cores in the apoferritin cavity. These synthesized CdS NPs with different photoluminescence properties will be applicable in a wide variety of nano-applications.
Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHighly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst†Zhaoguo Zhang, Guoxin Zhu, Qiongzhong Jiang, Dengming Xiao, and Xumu ZhangView Author Information Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 Cite this: J. Org. Chem. 1999, 64, 6, 1774–1775Publication Date (Web):February 27, 1999Publication History Received17 December 1998Published online27 February 1999Published inissue 1 March 1999https://doi.org/10.1021/jo9824605Copyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1534Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (65 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Enantioselective synthesis,Hydrogenation,Solvents,Stereoselectivity Get e-Alerts
Enabling Collaboration in Distributed Requirements Management (2006)

Requirements management, one of the most collaboration-intensive activities in software development, presents significant difficulties when stakeholders are distributed, as in today's global projects. Because of inadequate social contact, geographically distributed practitioners without appropriate tool support have trouble gaining a consistent understanding of requirements or managing requirement changes. We can alleviate many of these difficulties by integrating collaboration support in practitioners' work environments. With these needs in mind, we developed a new collaborative tool named EGRET (eclipse-based global requirements tool) for distributed requirements management
Laat elk kind gewenst zijn: zeven miljard mensen is niet duurzaam (2011)

Het is weer wat stil geworden rond de zeven miljardste wereldburger. Maar de uitdagingen die de bevolkingsexplosie stelt, zijn er niet minder om geworden: er is gewoon te weinig aarde om al die monden te voeden. De bevolkingsgroei afremmen blijft daarom de topprioriteit.
ANTIHAPTEN ANTIBODY SPECIFICITY AND L CHAIN TYPE (1967)

Two types of light polypeptide chain (kappa and lambda) are present in guinea pig immunoglobulins. The ratios of K/L molecules in anti-hapten antibodies differ sometimes markedly from that found in normal serum. Anti-DNP antibodies and anti-pipsyl antibodies have, respectively, a higher and a lower than normal K/L ratio. The possibility that the L chain type affects the range of configurations which the antibody-combining site may assume was investigated. Fractional precipitation of anti-DNP antibodies from serum of guinea pigs immunized with DNP(44)-BSA was performed using limiting amounts of antigen. Antibody fractions were purified from each precipitate, their affinities for epsilon-DNP-L-lysine measured by fluorescence quenching (K(0)) and the K/L ratio estimated by precipitation with specific antisera. Increasing concentrations of L molecules were found in fractions with decreasing K(0). In other experiments, fractional precipitation and purification of antibodies which cross-react with DNP was performed in serum of animals immunized with pipsyl-BGG. The K/L ratio in antibodies isolated from these fractions was much higher than in fractions which do not cross-react with DNP. These results show that K molecules are better adapted to react with the DNP hapten than L molecules. The K/L ratio in anti-DNP antibody was shown to increase in the course of immunization, at the same time that the K(0) is increasing. This rise in K(0) is markedly delayed when larger doses of antigen are employed.
Insights into Carbon Nanotube-Metal Oxide Composite: Embedding in Membranes (2017)

The fields of the nanocomposites and membranes have received a lot of attention and close examination of scientists and engineers in recent years. This makes it possible to design and create new materials with unprecedented flexibility.
High‐resolution three‐dimensional MR angiography of rodent tumors: Morphologic characterization of intratumoral vasculature (2003)

High-resolution three-dimensional MRA allows the visualization of intratumoral vasculature in rodent models. With minimal hardware and software modifications, high-resolution MRA could be performed on a clinical 1.5 T MRI scanner. Morphologic characterization of intratumoral blood vessels could add important insights into the process of tumor angiogenesis.
Studies on terpene glycosides. I. Synthesis and properties of menthyl glycosides. (1979)

With an aim of developing menthol derivatives having good solubility in water, the glycosidation reaction of menthols was extensively investigated, such as the condensation of menthols with acetobromoglucose by the method of Koenig-Knorr and that with fully acetylated sugars in the presence of acidic catalysts. The water-solubility of menthyl monosaccharides was generally poor, but that of menthyl disaccharides was good enough for practical usage as food additives and medicines. Furthermore, these glycosides derivatives were advantageously utilized for optical resolution of dl-menthol because of their high crystallinity.
Optical, mechanical, and thermal properties of barium borate (1987)

We report measurements of all the material constants necessary to fully characterize barium borate as a nonlinear optical material. All data was taken on crystals supplied by Professor Chuangtien Chen, Fuzhou, People’s Republic of China. We have determined the crystal structure, the optical absorption, the refractive indices from the UV to the near IR, the thermo-optic coefficients, the nonlinear optical or coefficients, the resistance to laser damage, the elastic constants, the thermal expansion, thermal conductivity and dielectric constants, and the fracture toughness. This data is used to evaluate barium borate for a variety of applications. We find that, in general, barium borate has a low acceptance angle, and that despite its higher optical nonlinearity, it is therefore not significantly more efficient than other commonly available materials, except in the UV below 250 nm. On the other hand, it has a high damage threshold, it is physically robust, it has good UV and IR transparency, and it has excellent average power capability. It permits deep UV generation, and has great potential for generating tunable visible and IR light as an optical parametric amplifier.
Cation complexing properties of synthetic macrocyclic polyether-diester ligands containing the pyridine subcyclic unit (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCation complexing properties of synthetic macrocyclic polyether-diester ligands containing the pyridine subcyclic unitJ. S. Bradshaw, G. E. Maas, J. D. Lamb, R. M. Izatt, and J. J. ChristensenCite this: J. Am. Chem. Soc. 1980, 102, 2, 467–474Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00522a004https://doi.org/10.1021/ja00522a004research-articleACS PublicationsRequest reuse permissionsArticle Views919Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidative stress‐induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara‐C (2001)

ABSTRACT Induction of apoptosis is considered to be the underlying mechanism that accounts for the efficiency of chemotherapeutic drugs. The identification of ceramide as a key mediator of apoptosis has made it possible to identify cellular entities that regulate drug‐induced sphingomyelinase activation. Using human leukemia cell lines, we demonstrate that 1‐β‐D‐arabinofuranosylcytosine (Ara‐C) stimulated ceramide generation, which was dependent on reactive oxygen species (ROS). Co‐immunoprecipitation studies revealed that Ara‐C‐generated ROS activated the scr kinase p53/p56 Lyn, which then recruited neutral sphingomyelinase and was responsible for its activation. These effects were blocked by herbimycin A and Lyn antisense oligonucleotides. In conclusion, this study establishes a series of events in which early ROS generated by Ara‐C leads to Lyn‐dependent neutral sphingomyelinase activation, JNK phosphorylation, and apoptosis.
Deposition of plasma polymerized perfluoromethylene-dominated films showing oil-repellency (2003)

Plasma polymerized fluorocarbon films were deposited onto polyethylene (PE) substrates to increase oil-repellency of PE. Depositions were performed using the monomer, 1H,1H,2H-perfluoro-1-dodecene in a parallel-plate, radio frequency (rf) reactor, with variable continuous-wave power ranging from 2 to 160 W. The film deposition rate and morphology were strongly dependent on the applied rf power. Most importantly, the chemical structure of the deposited films was also altered, resulting in changes in contact angles of various liquids and the surface energy. Films deposited at low power were composed mainly of perfluoromethylene (CF2) species (up to 67.2%), as shown by x-ray photoelectron spectroscopy (XPS). With an increase in rf power, CF2 content in the film decreased as further fragmentation of the monomer occurred. For each deposition at varying rf powers, even at powers as low as 2 W, the C=C and C–H bonds in the monomer were dissociated by the plasma and not incorporated into the films, as shown by Fourier transform infrared spectroscopy. Oil-repellency, as shown by increased contact angles of hydrocarbon liquids, was found to increase as the amount of CF2 species increased in the film structure. A low critical surface energy (2.7 mJ/m2) was calculated for the film deposited with only 2 W of rf power. Adhesion of the plasma-polymerized films to the PE was also evaluated and found to be poor for films with a high concentration of CF2 species, where cohesive failure within the film occurred. However, adhesion increased as a function of rf power, where the film structure showed more cross-linking. There was a compromise between producing a film with high oleophobicity (oil-repellency) while maintaining adhesion of the film to PE, as some disruption of the CF2 chains in the films was necessary for cohesion through cross-linking.
Usage model considerations for future distributed computing systems (2004)

Mass user adoption is often a good indication of a technology's success. We argue that the vision laid out by some distributed computing system (DCS) pioneer that "almost everyone who uses a pencil will use a computer" is still unrealized. We review the past and present DCS usage models and call for explicit attention to the end user's need. In particular, manageability, mobility, security, privacy, and ease of use demand attention from the research community. In addition to providing suggestions for addressing these requirements, we attempt to illustrate a "digital ink and paper" usage model technology which provides a good bridge between DCS users and those who still conduct their work solely on pencil and paper. We believe that this technology will bring us one step closer to realizing the vision of making the widely distributed computing system the universal vehicle for thinking and communications.
Inventory of Interbasin Transfers in the United States (2017)

Abstract Interbasin transfers ( IBT s) are man‐made transfers of water that cross basin boundaries. These transfers are used to distribute water resources according to supply and demand. The objectives of this work were to quantify the number of IBT s that exist in the United States (U.S.) and to examine the distribution of IBT s and potential causes associated with any observed clustering of IBT s. Defining “basin” was important to enable determination of which transfers qualify as “interbasin.” A variety of definitions are employed by states, with no federal definition. The most recent national studies of IBT s were conducted by the U.S. Geological Survey (USGS) in 1985 and 1986 using USGS Hydrologic Unit Code ( HUC ) definitions of basins. To build a 2016 inventory of IBT s in the U.S., and to identify where they most commonly occur, the USGS National Hydrography Database ( NHD ) was utilized in conjunction with the Watershed Boundary Dataset ( WBD ). Transfers across HUC 6 basin boundaries were considered interbasin. Geographical information analysis with the NHD and WBD databases revealed that there are a total of 2,161 man‐made waterways crossing HUC 6 basin boundaries in the U.S. IBT s are somewhat concentrated: Florida, Texas, and North Carolina account for over 50% of the total identified IBT s. For some states, identified IBT s are locally clustered. Analysis of these clusters suggests a variety of reasons that IBT s have been built, including population, drainage, and agricultural factors.
Large Eddy Simulation of Unsteady Flow in a Mixed Flow Pump Guide Vane (2013)

In order to investigate the characteristics of unsteady flow in a mixed flow pump guide vane under the small flow conditions, several indicator points in a mixed flow pump guide vane was set, the three-dimensional unsteady turbulence numerical value of the mixed flow pump which is in the whole flow field will be calculated by means of the large eddy simulation (LES), sub-grid scale model and sliding mesh technology. The experimental results suggest that the large eddy simulation can estimate the positive slope characteristic of head &amp; capacity curve. And the calculation results show that the pressure fluctuation coefficients of the middle section in guide vane inlet will decrease firstly and then increase. In guide vane outlet, the pressure fluctuation coefficients of section will be approximately axially symmetrical distribution. The pressure fluctuation minimum of section in guide vane inlet is above the middle location of the guide vane suction surface, and the pressure fluctuation minimum of section in which located the middle and outlet of guide vane. When it is under the small flow operating condition, the eddy scale of guide vane is larger, and the pressure fluctuation of the channel in guide vane being cyclical fluctuations obviously which leads to the area of eddy expanding to the whole channel from the suction side. The middle of the guide vane suction surface of the minimum amplitude pressure fluctuation to which the vortex core of eddy scale whose direction of fluids rotation is the same to impeller in the guide vane adhere.
ChemInform Abstract: Syntheses of Oxygen‐Bridged, Rigid Catecholamine Analogues. Effects on Adrenergic and Dopaminergic Systems. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.