gebhart/patrepeval huggingface dataset:
Synergistic Kinetic Interactions between Components of the Phosphorelay Controlling Sporulation in Bacillus subtilis (1998)

The four individual phosphotransfer steps in the multicomponent phosphorelay system controlling sporulation in Bacillus subtilis have been characterized kinetically using highly purified samples of the individual protein components in vitro. The autophosphorylation of KinA is the initial occurrence, and a divalent metal ion is required. KinA-mediated phosphotransfer, which displays a 57,000-fold preference (kcat/Km) for catalysis of Spo0F-P formation relative to Spo0A-P formation, is shown to proceed via a hybrid ping-pong/sequential mechanism with pronounced (> or = 40-fold) substrate synergism by Spo0F of KinA autophosphorylation. In addition, evidence is presented for formation of an abortive KinA.Spo0F complex. Kinetic parameters derived for Spo0F-P and Spo0A as substrates for Spo0B, the second phosphotransferase in the phosphorelay chain, indicate that Spo0B-mediated production of Spo0A-P is 1.1-million-fold more efficient (kcat/KSpo0A) than the direct KinA-mediated process. A rationale is presented for a four component cascade as the means for controlling sporulation, which focuses on the utility of synergistic interactions among the phosphorelay components that may be modulated by environmental stimuli.
Anomalous Hall effect from a non-Hermitian viewpoint (2023)

Non-Hermitian descriptions often model open or driven systems away from the equilibrium. Nonetheless, in equilibrium electronic systems, a non-Hermitian nature of an effective Hamiltonian manifests itself as unconventional observables such as a bulk Fermi arc and skin effects. We theoretically reveal that spin-dependent quasiparticle lifetimes, which signify the non-Hermiticity of an effective model in the equilibrium, induce the anomalous Hall effect, namely the Hall effect without an external magnetic field. We first examine the effect of nonmagnetic and magnetic impurities and obtain a non-Hermitian effective model. Then, we calculate the Kubo formula from the microscopic model to ascertain a non-Hermitian interpretation of the longitudinal and Hall conductivities. Our results elucidate the vital role of the non-Hermitian equilibrium nature in the quantum transport phenomena.
The calcilytic NPS2143 rectifies the gain-of-function associated with G-protein [alpha] 11 mutations causing autosomal dominant hypocalcaemia type 2 (2014)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Required concentration index quantifies effective drug combinations against hepatitis C virus infection (2021)

Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse antiviral effect during combination treatment. In the current study, a combined experimental and mathematical approaches were used to compare and score different combinations of anti-HCV treatments. A "required concentration index" was generated and used to rank the antiviral profile of possible double- and triple-drug combinations against HCV genotype 1b and 2a. Rankings varied based on target HCV genotype. Interestingly, multidrug (double and triple) treatment not only augmented antiviral activity, but also reduced genotype-specific efficacy, suggesting another advantage of multidrug treatment. The current study provides a quantitative method for profiling drug combinations against viral genotypes, to better inform clinical drug development.
High-Quality, Ultraconformal Aluminum-Doped Zinc Oxide Nanoplasmonic and Hyperbolic Metamaterials (2015)

Aluminum-doped zinc oxide (AZO) is a tunable low-loss plasmonic material capable of supporting dopant concentrations high enough to operate at telecommunication wavelengths. Due to its ultrahigh conformality and compatibility with semiconductor processing, atomic layer deposition (ALD) is a powerful tool for many plasmonic applications. However, despite many attempts, high-quality AZO with a plasma frequency below 1550 nm has not yet been realized by ALD. Here a simple procedure is devised to tune the optical constants of AZO and enable plasmonic activity at 1550 nm with low loss. The highly conformal nature of ALD is also exploited to coat silicon nanopillars to create localized surface plasmon resonances that are tunable by adjusting the aluminum concentration, thermal conditions, and the use of a ZnO buffer layer. The high-quality AZO is then used to make a layered AZO/ZnO structure that displays negative refraction in the telecommunication wavelength region due to hyperbolic dispersion. Finally, a novel synthetic scheme is demonstrated to create AZO embedded nanowires in ZnO, which also exhibits hyperbolic dispersion.
Shoulder Balance Following Correction Surgery for Adolescent Idiopathic Scoliosis (2021)

Study Design: This is a retrospective study. Objective: This study aims to determine (1) when shoulder rebalancing occurs after adolescent idiopathic scoliosis (AIS) correction surgery and (2) whether shoulder asymmetry was influenced by the use of pedicle screws or hooks. Summary of Background Data: Postoperative shoulder imbalance is an important outcome of AIS correction surgery as it may influence a patient’s appearance and satisfaction. Materials and Methods: Seventy AIS patients undergoing AIS correction surgery at a single institution were retrospectively reviewed. Radiographic parameters were measured from anteroposterior x-rays at preoperative, immediate postoperative, 6 months postsurgery, and 12 months postsurgery. Shoulder parameters measured were: radiographic shoulder height (RSH), clavicle angle, coracoid height difference (CHD), and T1 tilt. The Cobb angle of the proximal thoracic curve, major thoracic curve, and thoracolumbar/lumbar curve. The percentage of correction was also calculated. Results: Lateral shoulder asymmetry (RSH and CHD) changed significantly from preoperative to up to 6 months postsurgery. T1 tilt, a measure of medial shoulder asymmetry, did not change significantly. Postoperatively, the hook group attained significantly better shoulder balance than the screw group in terms of RSH and CHD up to 12 months postsurgery. However, the percentage correction of the major thoracic curve was significantly greater in the screw group than the hook group (hook: 62.2±18.4% vs. screw: 76.0±16.0%, P =0.007). Conclusions: Lateral shoulder rebalancing occurs up to 6 months after surgery. While thoracic pedicle screws offer greater correction of major AIS curves, hook constructs offer better postoperative shoulder symmetry. Level of Evidence: III.
Atomic Layer Deposition on Biological Macromolecules (2007)

Biomolecules play an increasingly important role in nanoscale science in recent years. Particularly, biomolecules with nanoscale dimensions are of special interest as templates for the fabrication of semiconducting or metallic nanostructures. In this work, we show the application of atomic layer deposition (ALD), a gas phase thin film deposition process, to biological macromolecules which are frequently used as templates in nanoscale science, and the possibility to fabricate thin films with embedded biomolecules.
Visceral Adiposity Predicts Severity of Acute Pancreatitis (2017)

Increased VAT area is a strong predictor of severe pancreatitis, necrosis, and multisystem organ failure.
How SIC-enabled LoRa Fares under Imperfect Orthogonality? (2021)

With the increase of connected Internet-of-things (IoT) devices, the need for low-power wide-area networks (LP-WANs) is imminent, and LoRaWAN is one such technology that offers an elegant solution to the problem of long-range communication and battery consumption. A parameter of special interest in LoRaWANis the spreading factor (SF), and it is often assumed that communication between different SFs is independent of each other. However, this claim has been practically debunked by many works, proving that SFs have imperfect orthogonality. To maximize connectivity and throughput, several techniques have been introduced, such as non-orthogonal-multiple-access (NOMA) and dynamic resource allocation. NOMA is getting a lot of attention recently, especially for IoT networks, because it embraces interference and tries to obtain desired information packets from corrupted ones. Furthermore, NOMA can be easily implemented on the base-station side by using the principle of successive interference cancellation (SIC). In this paper, we investigate how SIC, under the assumption of imperfect orthogonality of SF channels, can be used to increase the performance of the system. We find the expressions for success and coverage probability considering various SF allocation schemes and found the most efficient scheme for different scenarios.
Tamoxifen and meglumine antimoniate combined therapy in cutaneous leishmaniasis patients: a randomised trial (2018)

In the doses and schemes used in this study, co-administration of oral tamoxifen and Sb<sup>V</sup> resulted in higher cure rates in comparison with the standard scheme of treatment, although not to statistically significant levels.
Thermalization of atomic particles in gases (2011)

A model of the atomic particle thermalization process due to scattering in various gases with application of the Born-Mayer potential is presented. The thermalization process of atomic particles using the statistical modeling method is considered. Our thermalization model is adapted to a wide class of atomic collision partners, takes into account the real energy and angular distributions of atomic particle sources, and makes it possible to calculate the parameters of the spatial zone of their thermalization and transfer into the diffusion motion mode. The energy range of applicability for the atomic particle thermalization model is interesting for many applied problems in plasma physics, gas discharge, and ion plating processes.
The KDD process for extracting useful knowledge from volumes of data (1996)

article Free Access Share on The KDD process for extracting useful knowledge from volumes of data Authors: Usama Fayyad Jet Propulsion Laboratory, California Institute of Technology Jet Propulsion Laboratory, California Institute of TechnologyView Profile , Gregory Piatetsky-Shapiro GTE Laboratories GTE LaboratoriesView Profile , Padhraic Smyth University of California, Irvine and Jet Propulsion Laboratory, California Institute of Technology University of California, Irvine and Jet Propulsion Laboratory, California Institute of TechnologyView Profile Authors Info & Claims Communications of the ACMVolume 39Issue 11Nov. 1996pp 27–34https://doi.org/10.1145/240455.240464Published:01 November 1996Publication History 1,074citation15,552DownloadsMetricsTotal Citations1,074Total Downloads15,552Last 12 Months2,325Last 6 weeks471 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
An integrated scheme for automated video abstraction based on unsupervised cluster-validity analysis (1999)

Key frames and previews are two forms of a video abstract, widely used for various applications in video browsing and retrieval systems. We propose in this paper a novel method for generating these two abstract forms for an arbitrary video sequence. The underlying principle of the proposed method is the removal of the visual-content redundancy among video frames. This is done by first applying multiple partitional clustering to all frames of a video sequence and then selecting the most suitable clustering option(s) using an unsupervised procedure for cluster-validity analysis. In the last step, key frames are selected as centroids of obtained optimal clusters. Video shots, to which key frames belong, are concatenated to form the preview sequence.
Analysis of SOI MOSFET physics for compact modeling (2010)

This report shows an analysis of device operation on dynamic depletion mode of SOI MOSFETs, from view points of wide range geometry size, temperature and also considering device physics, second peak of gm, self-heating effect and so on. It is summarized a general picture of DD mode, which is important knowledge for next new compact circuit model.
Bismuth-based Quadruple Therapy Following H. pylori Eradication Failures: a Multicenter Study in Clinical Practice (2017)

Our study found that this bismuth-based quadruple therapy is highly effective as second-line and rescue therapy for H. pylori eradication in clinical practice.
Smoking cessation normalizes coronary endothelial vasomotor response assessed with 15O-water and PET in healthy young smokers. (2006)

Coronary vasomotor abnormality assessed by MBF response to the CPT was improved at 1 mo after smoking cessation. These findings indicate that coronary endothelial dysfunction may be reversible within 1 mo after smoking cessation in healthy young smokers.
Human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1 alpha (1995)

Pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepatocyte nuclear factor-1α is a protein with two different functions. We have overexpressed and purified the human wild-type protein, and its Cys81Ser and Cys81Arg mutants. The Cys81Arg mutant has been proposed to be causative in a hyperphenylalaninaemic patient [Citron, B. A., Kaufman, S., Milstien, S., Naylor, E. W., Greene, C. L. & Davis, M. D. (1993) Am. J. Hum. Genet. 53, 768 774]. The dehydratase behaves as a tetramer on gel filtration, while cross-linking experiments showed mono-, di-, tri-, and tetrameric forms, irrespective of the presence of the single Cys81. Sulfhydryl-modifying reagents did not affect the activity, but rather showed that Cys81 is exposed. Various pterins bind and quench the tryptophan fluorescence suggesting the presence of a specific binding site. The fluorescence is destroyed upon light irradiation. Wild-type and the Cys81Ser protein enhance the rate of the phenylalanine hydroxylase assay ≈ 10-fold, a value similar to that of native dehydratase from rat liver; the Cys81Arg mutant, in contrast, has significantly lower activity. This is compatible with the hypothesis that the dehydratase is a rate-limiting factor for the in vivo phenylalanine hydroxylase reaction. The three proteins enhance the spontaneous dehydration of the synthetic substrate 6,6-dimethyl-7,8-dihydropterin-4a-carbinolamine ≈50 70-fold at 4°C and pH 8.5. The results are discussed in view of the recently solved three-dimensional structure of the enzyme [Ficner, R., Sauer, U. W., Stier, G. & Suck, D. (1995) EMBO J. 14, 2032 2042].
The application of the virtual instrument technology in high voltage measuring system (2003)

The traditional way of high voltage (HV) measuring has some intrinsic shortcomings. With the recent improvement in digital measuring techniques and computers, digital automated measuring are become more prevalent. The virtual instrument (VI), which is a new technology in signal detecting, analyzing and processing, has been the authors' main focus. This paper introduces the concept and characters of VI, its three main types and presents a PC-based VI to measure 8/20 /spl mu/s impulse current. The VI is implemented in the two ways: the popular object-oriented programming language-Visual C++, and the famous graphical programming environment-LabVIEW. Signals are processed with the digital filter, smoothing window and fast Fourier transformation (FFT). Wave parameters can be calculated quickly and shown in the soft front panel. It can also be used to measure other high voltage waves after changed a little.
Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilation (2012)

Acellular hemoglobin (Hb)-based O2 carriers (HBOCs) are being investigated as red blood cell (RBC) substitutes for use in transfusion medicine. However, commercial acellular HBOCs elicit both vasoconstriction and systemic hypertension which hampers their clinical use. In this study, it is hypothesized that encapsulation of Hb inside the aqueous core of liposomes should regulate the rates of NO dioxygenation and O2 release, which should in turn regulate its vasoactivity. To test this hypothesis, poly(ethylene glycol) (PEG) conjugated liposome-encapsulated Hb (PEG-LEHs) dispersions were prepared using human and bovine Hb. In this study, the rate constants for O2 dissociation, CO association, and NO dioxygenation were measured for free Hb and PEG-LEH dispersions using stopped-flow UV-visible spectroscopy, while vasoactivity was assessed in rat aortic ring strips using both endogenous and exogenous sources of NO. It was observed that PEG-LEH dispersions had lower O2 release and NO dioxygenation rate constants compared with acellular Hbs. However, no difference was observed in the CO association rate constants between free Hb and PEG-LEH dispersions. Furthermore, it was observed that Hb encapsulation inside vesicles prevented Hb dependent inhibition of NO-mediated vasodilation. In addition, the magnitude of the vasoconstrictive effects of Hb and PEG-LEH dispersions correlated with their respective rates of NO dioxygenation and O2 release. Overall, this study emphasizes the pivotal role Hb encapsulation plays in regulating gaseous ligand binding/release kinetics and the vasoactivity of Hb.
Valence band x‐ray photoelectron spectroscopic studies of carbonate, bicarbonate and formate interpreted by Xα calculations (1993)

Abstract The valence band and core‐level x‐ray photoelectron spectroscopy (XPS) of carbonate, bicarbonate and formate is reported. There is little difference between these ions in the core XPS spectra. The valence band spectra of carbonate and formate are similar (with some differences in relative intensities) and agree well with the spectrum calculated by multiple‐scattered‐wave Xα calculations. The valence band spectra of carbonate and bicarbonate are found to be identical at ambient temperature, despite the fact that the valence band spectra calculated by Xα calculations are predicted to be different. The carbonate valence band spectrum agrees well with the calculated spectra. When the bicarbonate data are recorded at liquid nitrogen temperature, however, the valence band region agrees well with the calculated spectra. These results indicate that bicarbonate is readily decomposed at ambient temperatures in normal XPS instruments, and that carbonate and bicarbonate can be distinguished by differences in the valence band region if the latter is prevented from decomposition by recording the data at low temperatures.
Novel Cu-to-Cu Bonding With Ti Passivation at 180$^{\circ}{\rm C}$ in 3-D Integration (2013)

A novel CMOS-compatible bond structure using Cu-to-Cu bonding with Ti passivation is demonstrated at low temperature and investigated. With the Ti protection of inner Cu, Cu bonding temperature can be reduced to 180 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}{\rm C}$</tex></formula> . In addition, excellent electrical stability against humidity and temperature cycling is achieved. Diffusion behavior and mechanism of Cu and Ti are also discussed. With excellent bond results and reliability, this bonded scheme has the potential to be applied in 3-D integration.
Simultaneous Urethro-Cystometry with a New Technique (1976)

A new technique for studying simultaneous intravesical-intraurethral pressure is described. The basic principle of our technique is pressure recordings with the aid of micro-transducers. These micro-transducers have excellent frequency response, are easy to calibrate and to sterilize and are free from artefacts induced by motion. They permit a more accurate study of the pressures within the bladder and the urethra than catheter-transducer systems described earlier. Using electronical subtraction the closure pressure can easily be measured under static and dynamic conditions. Typical pressure diagrammes obtained with this catheter system are presented.
Systematic Internal Transcribed Spacer Sequence Analysis for Identification of Clinical Mold Isolates in Diagnostic Mycology: a 5-Year Study (2010)

The implementation of internal transcribed spacer (ITS) sequencing for routine identification of molds in the diagnostic mycology laboratory was analyzed in a 5-year study. All mold isolates (n = 6,900) recovered in our laboratory from 2005 to 2009 were included in this study. According to a defined work flow, which in addition to troublesome phenotypic identification takes clinical relevance into account, 233 isolates were subjected to ITS sequence analysis. Sequencing resulted in successful identification for 78.6% of the analyzed isolates (57.1% at species level, 21.5% at genus level). In comparison, extended in-depth phenotypic characterization of the isolates subjected to sequencing achieved taxonomic assignment for 47.6% of these, with a mere 13.3% at species level. Optimization of DNA extraction further improved the efficacy of molecular identification. This study is the first of its kind to testify to the systematic implementation of sequence-based identification procedures in the routine workup of mold isolates in the diagnostic mycology laboratory.