gebhart/patrepeval huggingface dataset:
Deep Flow-Guided Video Inpainting (2019)

Video inpainting, which aims at filling in missing regions in a video, remains challenging due to the difficulty of preserving the precise spatial and temporal coherence of video contents. In this work we propose a novel flow-guided video inpainting approach. Rather than filling in the RGB pixels of each frame directly, we consider the video inpainting as a pixel propagation problem. We first synthesize a spatially and temporally coherent optical flow field across video frames using a newly designed Deep Flow Completion network, then use the synthesized flow fields to guide the propagation of pixels to fill up the missing regions in the video. Specifically, the Deep Flow Competion network follows a coarse-to-fine refinement strategy to complete the flow fields, while their quality is further improved by hard flow example mining. Following the guide of the completed flow fields, the missing video regions can be filled up precisely. Our method is evaluated on DAVIS and YouTubeVOS datasets qualitatively and quantitatively, achieving the state-of-the-art performance in terms of inpainting quality and speed.
Whistler anisotropy instabilities as the source of banded chorus: Van Allen Probes observations and particle‐in‐cell simulations (2014)

Magnetospheric banded chorus is enhanced whistler waves with frequencies <i>ω</i><sub><i>r</i></sub> <Ω <sub><i>e</i></sub> , where Ω <sub><i>e</i></sub> is the electron cyclotron frequency, and a characteristic spectral gap at <i>ω</i><sub><i>r</i></sub> ≃Ω <sub><i>e</i></sub> /2. This paper uses spacecraft observations and two-dimensional particle-in-cell simulations in a magnetized, homogeneous, collisionless plasma to test the hypothesis that banded chorus is due to local linear growth of two branches of the whistler anisotropy instability excited by two distinct, anisotropic electron components of significantly different temperatures. The electron densities and temperatures are derived from Helium, Oxygen, Proton, and Electron instrument measurements on the Van Allen Probes A satellite during a banded chorus event on 1 November 2012. The observations are consistent with a three-component electron model consisting of a cold (a few tens of eV) population, a warm (a few hundred eV) anisotropic population, and a hot (a few keV) anisotropic population. The simulations use plasma and field parameters as measured from the satellite during this event except for two numbers: the anisotropies of the warm and the hot electron components are enhanced over the measured values in order to obtain relatively rapid instability growth. The simulations show that the warm component drives the quasi-electrostatic upper band chorus and that the hot component drives the electromagnetic lower band chorus; the gap at ∼Ω <sub><i>e</i></sub> /2 is a natural consequence of the growth of two whistler modes with different properties.
Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation (2015)

Hairy and enhancer of split 1 (Hes1), a basic helix-loop-helix transcriptional repressor protein, regulates the maintenance of neural stem/progenitor cells by repressing proneural gene expression via Notch signaling. Previous studies showed that Hes1 expression oscillates in both mouse embryonic stem cells and neural stem cells, and that the oscillation contributes to their potency and differentiation fates. This oscillatory expression depends on the stability of Hes1, which is rapidly degraded by the ubiquitin/proteasome pathway. However, the detailed molecular mechanisms governing Hes1 stability remain unknown. We analyzed Hes1-interacting deubiquitinases purified from mouse embryonic stem cells using an Hes1-specific antibody, and identified the ubiquitin-specific protease 27x (Usp27x) as a new regulator of Hes1. We found that Hes1 was deubiquitinated and stabilized by Usp27x and its homologs ubiquitin-specific protease 22 (Usp22) and ubiquitin-specific protease 51 (Usp51). Knockdown of Usp22 shortened the half-life of Hes1, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis-expression of Usp27x reduced neuronal differentiation. These results suggest that these deubiquitinases modulate Hes1 protein dynamics by removing ubiquitin molecules, and thereby regulate neuronal differentiation of stem cells.
Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2 (1999)

The differential modulation of learning and anxiety by corticotropin-releasing factor (CRF) through CRF receptor subtypes 1 (CRFR1) and 2 (CRFR2) is demonstrated. As learning paradigm, context- and tone-dependent fear conditioning of the mouse was used. Injection of CRF into the dorsal hippocampus before training enhanced learning through CRFR1 as demonstrated by the finding that this effect was prevented by the local injection of the unselective CRFR antagonist astressin, but not by the CRFR2-specific antagonist antisauvagine-30 (anti-Svg-30). In contrast, injection of CRF into the lateral intermediate septum impaired learning through CRFR2, as demonstrated by the ability of antisauvagine-30 to block this effect. When antisauvagine-30 was injected alone into the lateral intermediate septum, learning was enhanced. Such tonic control of learning was not observed when astressin or antisauvagine-30 was injected into the dorsal hippocampus. Injection of CRF after the training into the dorsal hippocampus and the lateral intermediate septum also enhanced and impaired learning, respectively. Thus, it was indicated that CRF acted on memory consolidation. It was concluded that the observed effects reflected changes of associative learning and not arousal, attention, or motivation. Although a dose of 20 pmol human/rat CRF was sufficient to affect learning significantly, a fivefold higher dose was required to induce anxiety by injection into the septum. Immobilization for 1 hr generated a stress response that included the induction of anxiety through septal CRFR2 and the subsequent enhancement of learning through hippocampal CRFR1. The involvement of either receptor subtype was demonstrated by region-specific injections of astressin and antisauvagine-30.
Key Role for Intracellular K+ and Protein Kinases Sat4/Hal4 and Hal5 in the Plasma Membrane Stabilization of Yeast Nutrient Transporters (2007)

K+ transport in living cells must be tightly controlled because it affects basic physiological parameters such as turgor, membrane potential, ionic strength, and pH. In yeast, the major high-affinity K+ transporter, Trk1, is inhibited by high intracellular K+ levels and positively regulated by two redundant "halotolerance" protein kinases, Sat4/Hal4 and Hal5. Here we show that these kinases are not required for Trk1 activity; rather, they stabilize the transporter at the plasma membrane under low K+ conditions, preventing its endocytosis and vacuolar degradation. High concentrations (0.2 M) of K+, but not Na+ or sorbitol, transported by undefined low-affinity systems, maintain Trk1 at the plasma membrane in the hal4 hal5 mutant. Other nutrient transporters, such as Can1 (arginine permease), Fur4 (uracil permease), and Hxt1 (low-affinity glucose permease), are also destabilized in the hal4 hal5 mutant under low K+ conditions and, in the case of Can1, are stabilized by high K+ concentrations. Other plasma membrane proteins such as Pma1 (H+ -pumping ATPase) and Sur7 (an eisosomal protein) are not regulated by halotolerance kinases or by high K+ levels. This novel regulatory mechanism of nutrient transporters may participate in the quiescence/growth transition and could result from effects of intracellular K+ and halotolerance kinases on membrane trafficking and/or on the transporters themselves.
Enzymatic Browning in Apple Pulps (1994)

ABSTRACT Enzymatic browning in Golden Delicious apple pulp was studied as related to degree of ripeness and temperature (3.5–31°C). Green apple pulp showed the highest rate of browning. This was attributable to differences in ascorbic acid (AA) content and polyphenoloxidase activity in young fruits. The rate of browning determined by CIE L* measurements followed complex temperature dependent kinetics, represented by a multiple linear effects with log time. Equal changes in L* parameter yielded straight lines in a log temperature vs log time plot. Inhibition with AA caused an initial slow rate of browning and a well defined break point associated with exhaustion of antioxidant properties of the AA. The greater the AA concentration the longer the initial period.
Faculty Opinions recommendation of Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1,6 glucan-cross-linked cell wall protein. (2002)

The yeast pathogen Candida glabrata adheres avidly to cultured human epithelial cells. This interaction depends on the expression of EPA1, which encodes a lectin belonging to a large family of GPI-anchored glucan-cross-linked cell wall proteins (GPI-CWPs) found in diverse fungal species. To understand the relationship between different domains of EPA1 and its function, we have mapped functional domains of Epa1p and analysed their contribution to Epa1p function. We found that the N-terminal third of the protein contains the ligand-binding domain, and that the GPI anchor is essential both for cross-linking in the cell wall and for Epa1p-mediated adherence. We also found that the C-terminal Ser/Thr-rich domain, characteristic of many GPI-CWPs, was absolutely essential for function. Although Epa1p derivatives lacking the Ser/Thr domain were expressed abundantly in the cell wall, they were localized to internal layers of the cell wall; such constructs were unable to mediate adherence. The outer layer of the yeast cell wall is known to act as a permeability barrier; we found that the C-terminal Ser/Thr-rich region was absolutely required to project the N-terminal domain of Epa1p through this permeability barrier and into the external environment. Thus, the Ser/Thr-rich domain of Epa1p and, presumably, of other related GPI-CWPs serves an essential structural role in localization of the protein at the external surface of the yeast cell where it can interact with its ligand. In conclusion, Epa1p has a modular structure, with each domain serving a distinct and essential role in the function of the adhesin. PMID: 12406223 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: AI46223
Functional Conservation of Phosphorylation-specific Prolyl Isomerases in Plants (2001)

The phosphorylation-specific peptidyl prolyl cis/trans isomerase (PPIase) Pin1 in humans and its homologues in yeast and animal species play an important role in cell cycle regulation. These PPIases consist of an NH(2)-terminal WW domain that binds to specific phosphoserine- or phosphothreonine-proline motifs present in a subset of phosphoproteins and a COOH-terminal PPIase domain that specifically isomerizes the phosphorylated serine/threonine-proline peptide bonds. Here, we describe the isolation of MdPin1, a Pin1 homologue from the plant species apple (Malus domestica) and show that it has the same phosphorylation-specific substrate specificity and can be inhibited by juglone in vitro, as is the case for Pin1. A search in the plant expressed sequence tag data bases reveals that the Pin1-type PPIases are present in various plants, and there are multiple genes in one organism, such as soybean (Glycine max) and tomato (Lycopersicon esculentum). Furthermore, all these plant Pin1-type PPIases, including AtPin1 in Arabidopsis thaliana, do not have a WW domain, but all contain a four-amino acid insertion next to the phospho-specific recognition site of the active site. Interestingly, like Pin1, both MdPin1 and AtPin1 are able to rescue the lethal mitotic phenotype of a temperature-sensitive mutation in the Pin1 homologue ESS1/PTF1 gene in Saccharomyces cerevisiae. However, deleting the extra four amino acid residues abolished the ability of AtPin1 to rescue the yeast mutation under non-overexpression conditions, indicating that these extra amino acids may be important for mediating the substrate interaction of plant enzymes. Finally, expression of MdPin1 is tightly associated with cell division both during apple fruit development in vivo and during cell cultures in vitro. These results have demonstrated that phosphorylation-specific PPIases are highly conserved functionally in yeast, animal, and plant species. Furthermore, the experiments suggest that although plant Pin1-type enzymes do not have a WW domain, they may fulfill the same functions as Pin1 and its homologues do in other organisms.
A Multi-Purpose Scenario-based Simulator for Smart House Environments (2011)

Developing smart house systems has been a great challenge for researchers and engineers in this area because of the high cost of implementation and evaluation process of these systems, while being very time consuming. Testing a designed smart house before actually building it is considered as an obstacle towards an efficient smart house project. This is because of the variety of sensors, home appliances and devices available for a real smart environment. In this paper, we present the design and implementation of a multi-purpose smart house simulation system for designing and simulating all aspects of a smart house environment. This simulator provides the ability to design the house plan and different virtual sensors and appliances in a two dimensional model of the virtual house environment. This simulator can connect to any external smart house remote controlling system, providing evaluation capabilities to their system much easier than before. It also supports detailed adding of new emerging sensors and devices to help maintain its compatibility with future simulation needs. Scenarios can also be defined for testing various possible combinations of device states; so different criteria and variables can be simply evaluated without the need of experimenting on a real environment.
Efficient manifold learning for speech recognition using locality sensitive hashing (2013)

This paper considers the application of a random projections based hashing scheme, known as locality sensitive hashing (LSH), for fast computation of neighborhood graphs in manifold learning based feature space transformations in automatic speech recognition (ASR). Discriminative manifold learning based feature transformations have already been found to provide significant improvements in ASR performance. The motivation of this work is the fact that the high computational complexity of these techniques has prevented their application to very large speech corpora. The performance of this integrated system is evaluated both in terms of computational complexity and ASR word recognition accuracy. Further comparisons of ASR performance with the well-known linear discriminant analysis are provided. These results demonstrate that LSH provides the much needed speed boost to manifold learning techniques with minimal impact on their ASR performance, thus enabling the application of these algorithms to large speech databases.
Verbal Workload in Distributed Air Traffic Management (1975)

The effects of alternative traffic management possibilities on task performance and pilot controller verbal workloads were studied. Two new rule structures - sequencing and advisory - in addition to vectoring were studied in conjunction with CRT pilot displays incorporating traffic situation displays with and without aircraft flight path predictors. The sequencing and advisory systems gave increasing control responsibility to the pilots. It was concluded that distributed management systems could in practice significantly reduce controller verbal workload without reducing system performance. Implications of this conclusion suggest that distributed management would allow controllers to handle a larger volume of traffic safely either as a normal operating procedure or as a failure mode alternative in a highly automated ground centered system.
Renal Dysfunction Is Associated with Middle Cerebral Artery Pulsatility Index and Total Burden of Cerebral Small Vessel Disease (2021)

&lt;b&gt;&lt;i&gt;Background and Purpose:&lt;/i&gt;&lt;/b&gt; Renal dysfunction is known to affect vasculature and lead to systemic arterial stiffness. It also independently increases the risk of cerebral small vessel disease (cSVD) and stroke. We aimed to examine the effect of renal dysfunction on cerebral hemodynamics and the burden of cSVD. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Of the 412 patients admitted to Seoul National University Hospital, between May 2015 and 2019, with lacunar infarction and no major intracranial arterial stenosis observed on magnetic resonance angiography, we included 283 patients who had undergone a transcranial Doppler (TCD) ultrasound after 72 h of stroke onset. The patients were divided into renal dysfunction (estimated glomerular filtration rate [eGFR] &amp;#x3c;60 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt; at admission) and control (eGFR ≥60 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt;) groups. We investigated the correlations between renal function, the pulsatility index (PI), and the total MRI burden of cSVD. Furthermore, multivariate analysis was performed to assess the association between renal dysfunction and the PI of the middle cerebral artery (MCA) measured through TCD ultrasound. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Among the total patients, 74 (26.1%) had renal dysfunction (eGFR &amp;#x3c;60 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt; at admission). Patients with renal dysfunction were significantly older, showed higher pulse pressure, and had a higher prevalence of hypertension, diabetes mellitus, and coronary artery disease. Renal dysfunction was significantly associated with higher distal cerebrovascular flow resistance (median PI 1.12, interquartile range [IQR]: 0.85–1.57 vs. controls 0.84, IQR: 0.54–1.22; &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.001). Also, patients with renal dysfunction had a significantly higher total MRI burden of cSVD (median cSVD score 2, IQR: 1–3 vs. controls median score 1, IQR: 0–2; &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.001). There was an inverse proportional relationship between the PI and eGFR. Finally, multivariate analysis showed renal dysfunction (adjusted odds ratio: 4.516, 95% confidence interval: 1.051–20.292) and older age (adjusted odds ratio: 1.076, 95% confidence interval: 1.038–1.114) as independent predictors of a high PI. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Renal dysfunction is independently associated with a high PI of MCA. Renal dysfunction leads to systemic arterial stiffness including stiffness in cerebral arteries, thus increasing the burden of cSVD. Therefore, noninvasive screening for high PI by TCD in kidney failure patients might be helpful.
<title>Articulated navigation testbed (ANT): an example of adaptable intrinsic mobility</title> (2000)

An important but oft overlooked aspect of any robotic system is the synergistic benefit of designing the chassis to have high intrinsic mobility which complements rather than limits, its system capabilities. This novel concept continues to be investigated by the Defence Research Establishment Suffield (DRES) with the Articulated Navigation Testbed (ANT) Unmanned Ground Vehicle (UGV). The ANT demonstrates high mobility through the combination of articulated steering and a hybrid locomotion scheme which utilizes individually powered wheels on the edge of rigid legs; legs which are capable of approximately 450 degrees of rotation. The configuration can be minimally configured as a 4x4 and modularly expanded to 6x6, 8x8, and so on. This enhanced mobility configuration permits pose control and novel maneuvers such as stepping, bridging, crawling, etc. Resultant mobility improvements, particularly in unstructured and off-road environments, will reduce the resolution with which the UGV sensor systems must perceive its surroundings and decreases the computational requirements of the UGV's perception systems<SUP>1</SUP> for successful semi-autonomous or autonomous terrain negotiation. This paper reviews critical vehicle developments leading up to the ANT concept, describes the basis for its configuration and speculates on the impact of the intrinsic mobility concept for UGV effectiveness.
Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase (1996)

The entry of RNA polymerase II into a productive mode of elongation is controlled, in part, by the postinitiation activity of positive transcription elongation factor b (P-TEFb) (Marshall, N. F., and Price, D. H. (1995) J. Biol. Chem. 270, 12335-12338). We report here that removal of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II abolishes productive elongation. Correspondingly, we found that P-TEFb can phosphorylate the CTD of pure RNA polymerase II. Furthermore, P-TEFb can phosphorylate the CTD of RNA polymerase II when the polymerase is in an early elongation complex. Both the function and kinase activity of P-TEFb are blocked by the drugs 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and H-8. P-TEFb is distinct from transcription factor IIH (TFIIH) because the two factors have no subunits in common, P-TEFb is more sensitive to DRB than is TFIIH, and most importantly, TFIIH cannot substitute functionally for P-TEFb. We propose that phosphorylation of the CTD by P-TEFb controls the transition from abortive into productive elongation mode.
A Raman Spectroscopic Investigation of Sulphadiazine and of Its Dirhodium Tetracarboxylate Adducts (1993)

Abstract A tentative assignment of the vibrational modes of sulphadiazine is made, based on the infrared and Raman data. In addition, dirhodium tetracarboxylates and their adducts with sulphadiazine are investigated by Raman spectroscopy, with emphasis in the identify the metal-metal and metalligand stretching modes.
(Invited) Building Better Batteries in the Solid State (2020)

Most of the current commercialized lithium batteries employ liquid electrolytes, despite their vulnerability to battery fire hazards, because they avoid the formation of dendrites on the anode side, which is commonly encountered in solid-state batteries. In a review two years ago, we focused on the challenges and issues facing lithium metal for solid-state rechargeable batteries (see J. Power Sources 353 (2017) 333-342), pointed to the progress made in addressing this drawback, and concluded that a situation could be envisioned where solid-state batteries would again win over liquid batteries for different applications in the near future. However, an additional drawback of solid-state batteries is the lower ionic conductivity of the electrolyte. Therefore, extensive research efforts have been invested in the last few years to overcome this problem, the reward of which has been significant progress. It is the purpose of this review to report these recent works and the state-of-the-art on solid electrolytes. In addition to solid electrolytes stricto sensu , there are other electrolytes that are mainly solids, but with some added liquid. In some cases, the amount of liquid added is only on the microliter scale; the addition of liquid is aimed at only improving the contact between a solid-state electrolyte and an electrode, for instance. In some other cases, the amount of liquid is larger, as in the case of gel polymers. It is also an acceptable solution if the amount of liquid is small enough to maintain the safety of the cell; such cases are also considered in this review. Different chemistries are examined, including not only Li-air, Li-O 2 , and Li-S, but also sodium-ion batteries, which are also subject to intensive research. The challenges toward commercialization are also considered.