gebhart/patrepeval huggingface dataset:
Signal transduction pathways involved in proteolysis-inducing factor induced proteasome expression in murine myotubes (2003)

The proteolysis-inducing factor (PIF) is produced by cachexia-inducing tumours and initiates protein catabolism in skeletal muscle. The potential signalling pathways linking the release of arachidonic acid (AA) from membrane phospholipids with increased expression of the ubiquitin-proteasome proteolytic pathway by PIF has been studied using C(2)C(12) murine myotubes as a surrogate model of skeletal muscle. The induction of proteasome activity and protein degradation by PIF was blocked by quinacrine, a nonspecific phospholipase A(2) (PLA(2)) inhibitor and trifluroacetyl AA, an inhibitor of cytosolic PLA(2). PIF was shown to increase the expression of calcium-independent cytosolic PLA(2), determined by Western blotting, at the same concentrations as those inducing maximal expression of 20S proteasome alpha-subunits and protein degradation. In addition, both U-73122, which inhibits agonist-induced phospholipase C (PLC) activation and D609, a specific inhibitor of phosphatidylcholine-specific PLC also inhibited PIF-induced proteasome activity. This suggests that both PLA(2) and PLC are involved in the release of AA in response to PIF, and that this is important in the induction of proteasome expression. The two tyrosine kinase inhibitors genistein and tryphostin A23 also attenuated PIF-induced proteasome expression, implicating tyrosine kinase in this process. PIF induced phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) at the same concentrations as that inducing proteasome expression, and the effect was blocked by PD98059, an inhibitor of MAPK kinase, as was also the induction of proteasome expression, suggesting a role for MAPK activation in PIF-induced proteasome expression.
Amended Data on Arginine Utilization by Spiroplasma Species (1996)

Hydrolysis of arginine is a classical diagnostic test for species in the mollicute order Entomoplasmatales. In this paper we report data for arginine utilization by spiroplasmas, as determined by standard methods. In addition, modified methods were developed for fastidious spiroplasmas, such as strain LD-1T (T = type strain), the Colorado potato beetle spiroplasma. Twenty-one spiroplasma strains representing 13 groups or subgroups and eight ungrouped spiroplasmas (seven of which represent putative groups) were studied. The arginine reactions of eight strains were the same as the reactions reported previously, but previously reported positive tests for spiroplasma subgroups I-5 and I-6 (Spiroplasma insolitum) could not be repeated, and the data for the latter taxa are corrected. Although other workers have reported that addition of carbohydrate to media may be necessary for the utilization of arginine, the presence of glucose tended to obscure arginine hydrolysis in our studies.
Progress in Diamanes and Diamanoids Nanosystems for Emerging Technologies (2022)

New materials are the backbone of their technology-driven modern civilization and at present carbon nanostructures are the leading candidates that have attracted huge research activities. Diamanes and diamanoids are the new nanoallotropes of sp<sup>3</sup> hybridized carbon which can be fabricated by proper functionalization, substitution, and via Birch reduction under controlled pressure using graphitic system as a precursor. These nanoallotropes exhibit outstanding electrical, thermal, optical, vibrational, and mechanical properties, which can be an asset for new technologies, especially for quantum devices, photonics, and space technologies. Moreover, the features like wide bandgap, tunable thermal conductivity, excellent thermal insulation, etc. make diamanes and diamanoids ideal candidates for nano-electrical devices, nano-resonators, optical waveguides, and the next generation thermal management systems. In this review, diamanes and diamanoids are discussed in detail in terms of its historical prospect, method of synthesis, structural features, broad properties, and cutting-edge applications. Additionally, the prospects of diamanes and diamanoids for new applications are carefully discussed. This review aims to provide a critical update with important ideas for a new generation of quantum devices based on diamanes and diamanoids which are going to be an important topic in the future of carbon nanotechnology.
Parallel Design of Feedback Control Systems Utilizing Dead Time for Embedded Multicore Processors (2016)

This paper presents a parallelization method utilizing dead time to implement higher precision feedback control systems in multicore processors. The feedback control system is known to be difficult to parallelize, and it is difficult to deal with the dead time in control systems. In our method, the dead time is explicitly represented as delay elements. Then, these delay elements are distributed to the overall systems with equivalent transformation so that the system can be simulated or executed in parallel pipeline operation. In addition, we introduce a method of delay-element addition for parallelization. For a spring-mass-damper model with a dead time, parallel execution of the model using our technique achieves 3.4 times performance acceleration compared with its sequential execution on an ideal four-core simulation and 1.8 times on a cycle-accurate simulator of a four-core embedded processor as a threaded application on a real-time operating system.
Mathematical Methods for Physicists (2019)

"The book covers different aspects of mathematical methods for Physics. It is designed for graduate courses but a part of it can also be used by undergraduate students. The leitmotiv of the book is the search for a common mathematical framework for a wide class of apparently disparate physical phenomena. An important role, within this respect, is provided by a nonconventional formulation of special functions and polynomials. The proposed methods simplify the understanding of the relevant technicalities and yield a unifying view to their applications in Physics as well as other branches of science. The chapters are not organized through the mathematical study of specific problems in Physics, rather they are suggested by the formalism itself. For example, it is shown how the matrix formalism is useful to treat ray Optics, atomic systems evolution, QED, QCD and Feynman diagrams. The methods presented here are simple but rigorous. They allow a fairly substantive tool of analysis for a variety of topics and are useful for beginners as well as the more experienced researchers."--
Midgut proteases from Mamestra configurata (Lepidoptera: Noctuidae) larvae: Characterization, cDNA cloning, and expressed sequence tag analysis (2003)

The activities of digestive protease within the midgut of Mamestra configurata (bertha armyworm) larvae were examined using specific substrates and protease inhibitors. The bulk of the activity was associated with serine proteases comprising trypsin-, chymotrypsin-, and elastase-like enzymes. At least 10-15 serine protease isozymes were detected using one-dimension gelatin gel electrophoresis. Cysteine or aspartic protease activities were not present; however, amino- and carboxypeptidase activities were associated with the midgut extract. Midgut proteases were active in the pH range of 5.0-12.0 with peaks at pH 7.5 and 11.0. In general, the middle region of the midgut exhibited a higher pH (approximately 8.0) than either the posterior or anterior regions (approximately 7.3-7.7). Moulting larvae possessed a neutral gut pH that was 0.5-1.5 units below that of feeding larvae. Degenerate PCR and expressed sequence tag (EST)-based approaches were used to isolate 30 distinct serine protease encoding cDNAs from a midgut-specific cDNA library including 8 putative trypsins, 9 chymotrypsins, 1 elastase, and 12 whose potential activities could not be determined. cDNAs encoding three amino- and two carboxypeptidases were also identified. Larvae feeding upon artificial diet containing 0.2% soybean trypsin inhibitor experienced a significant delay in development.
Capturing Information Flow with Concatenated Dynamic Taint Analysis (2009)

Dynamic taint analysis (DTA) is a technique used for tracking information flow by propagating taint propagation across memory locations during program execution. Most implementations of DTA are based on dynamic binary instrumentation (DBI) frameworks or whole-system emulators/virtual machine monitors. The boundary of information tracking with DBI frameworks is a single process, while system emulators can cover a host, including the OS. Using system emulators, it may be possible to consider taint propagation across multiple processes executing locally, within the emulator. However, there is an increasing need for tracking information flow across single-system boundaries and across the whole enterprise. We describe a proof-of-concept architecture for tracking multiple mixed-information flows among several processes across a distributed enterprise. Our DTA tool is based on PIN, a DBI framework by Intel, and the concatenated DTA processing is realized with per-host flow managers. We have tested our prototype with typical enterprise applications. As a motivating example, we track information leakage due to a SQL injection attack from a web-based database server query. Our work is of an exploratory nature, aiming to expose our early findings and identify areas where additional research is needed in improving usability and performance.
Reconfigurable Surface Design for Electromagnetic Wave Control (2020)

A reconfigurable surface, for electromagnetic (EM) wave manipulation, utilizing frequency selective unit-cells integrated with PIN diodes are introduced. By digitally controlling the reconfigurable surface, several functionalities such as focusing, linear polarization conversion and scattering are obtained on the same surface. For the scattering purposes, three arrangement methods of alternative periodic columns, chessboard-like structure and coding surface optimized by GSO algorithm are analyzed. For the coded surface, 10-dB RCS reduction from 15.5 GHz to 22.5 GHz is obtained with a bandwidth of 37%. All the results show that the introduced reconfigurable surface has more potential for future applications.
Evidence for Carrier-Mediated Transport of Monosaccharides in the Ehrlich Ascites Tumor Cell (1967)

Evidence for carrier-mediated transport of monosaccharides in the Ehrlich ascites tumor cells was provided through kinetic analysis of data obtained by: (a) studying sugar uptake by dilute cell suspensions with an optical densimetric apparatus, (b) studying sugar uptake by thicker cell suspensions by means of direct chemical analytical methods using packed cell plugs, (c) observing the effects of a competitive inhibitor upon sugar uptake with the chemical analytical method, and (d) measurement of tracer uptake of a high affinity sugar in thick cell suspensions in the absence of net movement. Quantitative application of the data obtained with the above experimental procedures to theoretical model systems derived for both carrier-mediated transport and simple passive diffusion indicated that the results were consonant with predictions for the carrier-mediated transport model, but could not be explained on the basis of uncomplicated diffusion.
Depressed Myocardial Creatine Phosphokinase Activity Following Experimental Myocardial Infarction in Rabbit (1970)

Since creatine phosphokinase (CPK) is found predominantly in myocardial and skeletal muscle cells, in contrast to cells participating in the inflammatory response, it was considered likely that measurement of activity of this enzyme in the heart would provide a sensitive and relatively specific index of the extent of ischemic injury following acute coronary artery occlusion. Accordingly, CPK activity was measured serially following coronary artery occlusion in extracts from rabbit myocardium with gross infarction and from normal rabbit left ventricle. In addition, myocardial CPK activity was assayed in extracts from various portions of dog hearts 24 hours after ligation of the coronary artery. CPK activity of rabbit myocardium with infarction was uniformly depressed within 6 hours following coronary occlusion. After 24 hours, activity declined from 15.5±0.9 (mean±SE) to 3.4±0.3. CPK activity in whole left ventricular extracts was depressed and in general, the extent of depression was proportional to the size of the gross infarct. CPK depression in various regions of the dog heart 24 hours after coronary occlusion correlated with the extent of reduction of blood flow determined with the use of radioactively labeled microspheres. Results suggest that depression of myocardial CPK activity may be useful in estimating the extent of tissue damage following experimental coronary artery occlusion and the effect of prophylactic and therapeutic measures on the survival of myocardium in this setting.
Study on frequency-tracking wireless power transfer system by resonant coupling (2009)

Detuning is the application barrier of resonant coupling wireless power transfer. This paper analyzes the effects about inductance variations of launch coil and receiving coil to wireless transmission efficiency from its transmission mechanism and model, and also analyzes detuning mechanism. And thus, it reveals that transmission efficiency has a great affection with inductance of launch coil changing. In order to make sure that wireless power transfer by resonant coupling operates without detuning, a new method of frequency tracking control is came up with, which is, making frequency of transmitting power source tracking with the nature frequency of launch resonant circuit automatically. Hence, it avoids detuning and improves transmission efficiency greatly. Finally, a prototype of 1 MHz wireless power transfer system by resonant coupling was made. Experimental results prove this method very well.
Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells. (1994)

Intercellular adhesion molecule-1 (ICAM-1) modulates epithelial and endothelial leukocyte adherence, but epithelial cell ICAM-1 levels (unlike endothelial cell levels) are selectively sensitive to interferon-gamma (IFN-gamma). Nuclear run-off assays indicated that IFN-gamma regulation of epithelial ICAM-1 levels occurs at a transcriptional level, so the basis for selective cytokine control of ICAM-1 expression was investigated using the ICAM-1 gene promoter region. A plasmid construct containing 5.0 kilobases of ICAM-1 gene 5'-flanking region fused to a reporter gene was selectively responsive to IFN-gamma in (human tracheal) epithelial cells but not in (human umbilical vein) endothelial cells, indicating that this region is sufficient to mediate proper cell-specific expression. An IFN-gamma response element (IRE) was localized to a DNA segment (nucleotides -130 to -94) in the ICAM-1 gene by comparisons of nested 5'-deletional constructs and by demonstrating that this segment confers IFN-gamma responsiveness on heterologous promoters. This same IRE formed a single major binding complex (IRE-BC) in gel retardation assays with nuclear proteins from IFN-gamma-stimulated but not unstimulated epithelial cells, and mutation of the IRE consensus motif (TTTCCGGGAAA at -116 to -106) resulted in loss of IRE-protein binding and abolished IFN-gamma responsiveness, indicating that this sequence is required for ICAM-1 IRE function. Comparison of the ICAM-1 IRE to DNA elements that confer IFN responsiveness in other human genes indicated similarity only to response regions in the Fc gamma RI and IRF-1 genes. The findings provide evidence for a distinct IRE subset that combines a DNA element common to all IFN-responsive genes (GAAA) with a distinct flanking sequence (the inverted repeat GAAA) in order to fine-tune IFN responses and activate a subset of immune response genes (ICAM-1, Fc gamma RI, and IRF-1).
Clinical indications and triaging for adult transthoracic echocardiography: a consensus statement by the British Society of Echocardiography in collaboration with British Heart Valve Society (2022)

Transthoracic echocardiography (TTE) is widely utilised within many aspects of clinical practice, as such the demand placed on echocardiography services is ever increasing. In an attempt to provide incremental value for patients and standardise patient care, the British Society of Echocardiography in collaboration with the British Heart Valve Society have devised updated guidance for the indications and triaging of adult TTE requests for TTE services to implement into clinical practice.
Creation of Nickel-Based Active Species within a Macroreticular Acidic Resin: A Noble-Metal-Free Heterogeneous Catalyst for Visible-Light-Driven H2 Evolution from Water (2014)

An acidic resin bearing −SO3– functional groups within its macroreticular structure acts as an efficient support for in situ formation of a noble-metal-free Ni-based catalyst responsible for visible-light-driven H2 production from water. Characterization by means of XAFS revealed that simple ion-exchange of the resin with a trinuclear Ni complex, Ni(NiL2)2Cl2 (L = β-mercaptoethylamine), affords monomeric Ni(II) species involving β-mercaptoethylamine and aqua ligands in an octahedral coordination geometry, which is easily transformed into real active species containing a TEOA ligand during the initial induction period of the photocatalytic reaction. Such in situ-generated Ni species offer a simple and efficient photocatalytic system whose activity is five times greater than that of its homogeneous counterpart, enabling efficient H2 production when xanthene dye is employed as a visible-light-responsive photosensitizer. The acidity of the resins as well as β-mercaptoethylamine and the TEOA ligands were found to be key factors in achieving efficient catalytic performance. Moreover, leaching and agglomeration of the active Ni species were not observed, and the recovered catalyst could be recycled without significant loss of activity.
Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever (2011)

The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks.
Detecting and leveraging finger orientation for interaction with direct-touch surfaces (2009)

Current interactions on direct-touch interactive surfaces are often modeled based on properties of the input channel that are common in traditional graphical user interfaces (GUI) such as x-y coordinate information. Leveraging additional information available on the surfaces could potentially result in richer and novel interactions. In this paper we specifically explore the role of finger orientation. This property is typically ignored in touch-based interactions partly because of the ambiguity in determining it solely from the contact shape. We present a simple algorithm that unambiguously detects the directed finger orientation vector in real-time from contact information only, by considering the dynamics of the finger landing process. Results of an experimental evaluation show that our algorithm is stable and accurate. We then demonstrate how finger orientation can be leveraged to enable novel interactions and to infer higher-level information such as hand occlusion or user position. We present a set of orientation-aware interaction techniques and widgets for direct-touch surfaces.
Counting Deaths Due to Medical Errors—Reply (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India (2005)

Death from myocardial infarction (MI) in India is exacerbated by smoking of bidis or cigarettes. Smoking among 309 men with incident MI was compared to 618 age matched controls; 56% of the individuals with MI and 26% of controls were current smokers. Current smokers had a relative risk of 4.7 (95% confidence interval (CI) 3.2 to 6.9) compared to never smokers. Relative risks for smoking more than 10 cigarettes or 10 bidis daily were 9.1 (95% CI 4.7 to 17.7) and 8.1 (95% CI 4.3 to 15.3), respectively. It is estimated that smoking may cause 53% (95% CI 47% to 64%) of MIs among urban males in India.
Estratégia formativa para o sector agro-industrial (2013)

A necessidade de dar resposta a lacunas na formação no setor agroindustrial levou ao desenvolvimento de uma estratégia formativa dirigida especificamente para este setor e assente num levantamento das necessidades formativas identificadas e num levantamento da oferta formativa existente e das entidades formadoras que a lecionam, em Portugal. Este artigo pretende, assim, apresentar o desenho de uma estratégia de formação que pretende ir ao encontro das necessidades reais das empresas deste setor. Desta forma contribuirá para a melhoria das suas performances operacionais capacitando o setor com competências fundamentais para o seu desenvolvimento e melhoria de competitividade. O trabalho desenvolvido em que assenta esta estratégia formativa tem âmbito nacional e em metodologias de definição de uma estratégia empresarial. Desta forma pretende-se alcançar impacto e objetividade num quadro nacional de oferta formativa, sem duplicações de planos de formação, mas especificamente orientados para as necessidades específicas de um setor. A estratégia apresentada neste artigo foi definida no âmbito do projeto-âncora AgriTraining com atividades englobadas dentro do programa de ação da InovCluster, apoiado pelo Quadro de Referência Estratégico Nacional, na medida em que foi reconhecido a necessidade de promover o aumento da produtividade através do desenvolvimento e modernização de técnicas e sistemas tradicionais no sector agroindustrial.