gebhart/patrepeval huggingface dataset:
An Extendible Simulation Game to Promote Team Spirit on Mobile Computing Devices (2011)

Game based learning (GBL) has significantly reshaped the latest educational or training technologies through engaging players in many carefully planned learning activities in real-world applications including the training of tactic planning in a simulated combat environment, or resource management for any large organization. Successful examples range from the commercially available simulation games like SimBusiness, being adopted in some business schools in North America, to Quest Atlantis as a 3D multi-user learning game platform to children aged 9 – 15 in meaningful inquiry tasks. In a previous Teaching Development Project, the authors of this chapter developed an interesting simulation game platform for a virtual university campus containing game rooms with different missions for students to fulfill so as to enhance the learners’ experience after classes on ubiquitous computing devices. All the missions are focused on engaging players to exercise their logical thinking or problem-solving skills in relevant areas of Information and Communication Technologies (ICT). To promote team spirit, each group of 3 to 4 students will work together to complete all the missions within the virtual campus. The authors used the open-source Nebula Version 2.0 toolkit to build a prototype of our simulation game containing various game rooms inside a virtual campus that can be accessed through any Windows based desktop or pocket PCs. To allow the real-time chatting facility among team members, the Yet Another Telephony Engine (YATE) server is employed in the interactive game platform. A preliminary evaluation was conducted to analyze the effectiveness of the simulation game on motivating and/or enhancing the learners’ experience in relevant disciplines. All in all, there are many interesting directions for further investigations including the integration of our simulation game with existing learning management system or increasing players’ involvement in proposing new missions.
Preliminary evaluation of a walking controller for a powered ankle prosthesis (2013)

This paper describes a level walking controller for a powered ankle prosthesis. The controller was implemented on a powered prosthesis prototype and evaluated on a healthy subject by means of able-bodied adapters on a treadmill walking at 1.2 m/s (4.3 km/h). The ankle joint kinematics provided by the powered prosthesis were compared to that provided by a passive (dynamic elastic response) prosthesis, and both compared to the typical kinematics of healthy gait. The comparison indicates the powered prosthesis better reproduces the kinematics of healthy gait, relative to the passive prosthesis. The torque, energy transfer, and power provided by the powered prosthesis were additionally compared to that of a typical healthy subject.
Chaotic oscillations enhanced by magnetosonic waves in plasma-filled traveling-wave tubes (1998)

A theory of plasma-filled traveling-wave tubes (TWTs) is developed in which the effect of magnetosonic waves excited in plasma by the operating wave is taken into account. These waves are excited by the ponderomotive force caused by the radial inhomogeneity of the axial component of the electric field of the operating wave. In the simplest case considered in the paper, this effect leads to an additional reactive nonlinearity in the wave envelope equation. This leads to a shrinkage of the region of stable oscillations in TWTs with the feedback causing the self-excitation; at the same time, the region of stochastic oscillations becomes larger. The radiation spectrum of stochastic oscillations in plasma-filled TWTs in which magnetosonic waves are excited is much wider and more continuous than the spectrum of stochastic oscillations in vacuum TWTs with the same feedback.
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function (2022)

Abstract FOXP3 + regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elevated in mice and in in vitro -generated human Treg cells. NCOR1-deficient Treg cells failed to protect mice from severe weight loss and intestinal inflammation associated with CD4 + T cell transfer colitis, indicating impaired suppressive function. NCOR1 controls transcriptional integrity of Treg cells, since effector gene signatures were already upregulated in naïve NCOR1-deficient Treg cells while effector NCOR1-deficient Treg cells failed to repress genes associated with naïve Treg cells. Moreover, genes related to cholesterol homeostasis including targets of liver X receptor (LXR) were dysregulated in NCOR1-deficient Treg cells. However, genetic ablation of LXRβ in T cells did not revert the effects of NCOR1 deficiency, indicating that NCOR1 controls naïve and effector Treg cell subset composition independent from its ability to repress LXRβ-induced gene expression. Thus, our study reveals that NCOR1 maintains naïve and effector Treg cell states via regulating their transcriptional integrity. We also reveal a critical role for this epigenetic regulator in supporting the suppressive functions of Treg cells in vivo .
Antimicrobial peptides and proteins of the horse - insights into a well-armed organism (2011)

Antimicrobial peptides play a pivotal role as key effectors of the innate immune system in plants and animals and act as endogenous antibiotics. The molecules exhibit an antimicrobial activity against bacteria, viruses, and eukaryotic pathogens with different specificities and potencies depending on the structure and amino-acid composition of the peptides. Several antimicrobial peptides were comprehensively investigated in the last three decades and some molecules with remarkable antimicrobial properties have reached the third phase of clinical studies. Next to the peptides themselves, numerous organisms were examined and analyzed regarding their repertoire of antimicrobial peptides revealing a huge number of candidates with potencies and properties for future medical applications. One of these organisms is the horse, which possesses numerous peptides that are interesting candidates for therapeutical applications in veterinary medicine. Here we summarize investigations and knowledge on equine antimicrobial peptides, point to interesting candidates, and discuss prospects for therapeutical applications.
Room Temperature Phosphorescence Study of Phosphate Binding in Escherichia Coli Alkaline Phosphatase (1997)

The phosphorescence spectrum and decay of Trp109 in Escherichia coli alkaline phosphatase was measured for the enzyme in 10 mM Tris/HCl, pH 7.4, at 21 degrees C. Changes in the spectrum and decay from the steady-state in response to non-covalent phosphate binding suggested a phosphate-induced alteration in the local environment surrounding Trp109 which lies buried below the active site. The seemingly inflexible structure in the region of Trp109, as judged by its very long phosphorescence lifetime, appeared unaltered when the enzyme was symmetrically bound with phosphate. However, the protein with phosphate bound to only one site displayed a marked increase in flexibility that extended over both subunits. For ratios of phosphate/enzyme (mol/mol) between 1.0 and 2.0, the observation of exponential phosphorescence decays with lifetimes that are a function of dilution provided evidence for the rapid exchange between phosphate half-saturated and fully-saturated enzymes consistent with observed enzyme turnover rates. The lifetimes under these conditions result in the calculation of a Kd for the dissociation of phosphate from the doubly occupied enzyme of 1.1 +/- 0.1 microM. The non-exponential decays at P/Ed (phosphate/dimeric enzyme) ratios less than 1.0 revealed that the exchange of phosphate between phosphate-free and half-saturated enzymes was not occurring on the timescale of the phosphorescence decay times, which implied that the half-saturated molecule cannot be contributing significantly to catalysis under steady-state conditions. The observation that the phosphorescence decay at a P/Ed ratio of 1.0 is exponential with a lifetime characteristic of the half-saturated species indicates that the binding of the first phosphate is significantly greater than the second, or that the binding exhibits negative cooperativity.
Effet de la vitesse de chargement sur le comportement mécanique de pieux modèle en chambre d'étalonnage (2001)

International audience
Control of seed germination in transgenic plants based on the segregation of a two-component genetic system (2003)

We have developed a repressible seed-lethal (SL) system aimed at reducing the probability of transgene introgression into a population of sexually compatible plants. To evaluate the potential of this method, tobacco plants were transformed with an SL construct comprising gene 1 and gene 2 from Agrobacterium tumefaciens whereby gene 1 was controlled by the seed-specific phaseolin promoter modified to contain a binding site for the Escherichia coli TET repressor (R). The expression of this construct allows normal plant and seed development but inhibits seed germination. Plants containing the SL construct were crossed with plants containing the tet R gene to derive plant lines where the expression of the SL construct is repressed. Plant lines that contained both constructs allowed normal seed formation and germination, whereas seeds in which the SL construct was separated from the R gene through segregation did not germinate. The requirements of such a method to efficiently control the flow of novel traits among sexually compatible plants are discussed.
Nuclear Localization of the Adenovirus DNA-Binding Protein: Requirement for Two Signals and Complementation during Viral Infection (1989)

The adenovirus DNA-binding protein (DBP) is an abundant multifunctional protein located primarily in the nuclei of infected cells. To define sequences involved in nuclear transport of DBP, a series of point and small deletion mutants were constructed via oligonucleotide-directed mutagenesis. Two short stretches of basic amino acids located in the amino-terminal domain (amino acids 42 to 46 and 84 to 89) were identified. Their importance, however, depended on the context in which DBP was expressed. Disruption of either site prevented nuclear localization after transient expression in transfected 293 cells, implying that two nuclear localization signals are necessary for transport of this nuclear protein. In contrast, the mutant DBPs synthesized during viral infection were located either primarily in the nucleus or in the nucleus and cytoplasm, depending on the mutation and the stage of the viral infection. Thus, the nuclear localization defect could be complemented by viral infection, perhaps through the interaction of the mutant polypeptide with a virus-encoded or -induced factor(s).
End-to-end dexterous manipulation with deliberate interactive estimation (2012)

This paper presents a model based approach to autonomous dexterous manipulation, developed as part of the DARPA Autonomous Robotic Manipulation (ARM) program. The developed autonomy system uses robot, object, and environment models to identify and localize objects, and well as plan and execute required manipulation tasks. Deliberate interaction with objects and the environment increases system knowledge about the combined robot and environmental state, enabling high precision tasks such as key insertion to be performed in a consistent framework. This approach has been demonstrated across a wide range of manipulation tasks, and in independent DARPA testing archived the most successfully completed tasks with the fastest average task execution of any evaluated team.
Executable system architecting using systems modeling language in conjunction with colored Petri nets in a model‐driven systems development process (2011)

Abstract This work proposes an executable system architecting paradigm for discrete‐event system modeling and analysis through integration of a set of modeling tools, executable formalisms, analytical tools, and animation tools. The essential step is converting SysML‐based specifications into colored Petri nets through a conversion scheme proposed here. Such a paradigm permits rigorous static and dynamic system analysis, as well as formal verification of the behavior and functionality of the SysML‐based design. This paper also compares the capabilities of the proposed executable system architecting paradigm with other executable formalisms. Further, it discusses the basic principles of executable architecture specification and analysis for discrete‐event system modeling. The model‐driven architecture approach developed from the software engineering field is also studied here and applied in a systems engineering context to create a SysML‐based modeling process that maintains a close relationships among all the SysML diagrams and indicates which diagrams to build and how to build them. This executable architecting paradigm is then integrated into the model‐driven systems development process to create a structured architecture design process. This methodology is aimed at general system design. Its feasibility is demonstrated using the example of the Global Earth Observation System of Systems, which is modeled as a distributed, parallel information processing system. The simulation results are used to check the overall integrity and internal consistency of the architecture models, to refine the architecture design, and finally, to verify the behavior and functionality of the system modeled. © 2011 Wiley Periodicals, Inc.
Frequency-locked multicarrier generator based on a complementary frequency shifter with double recirculating frequency-shifting loops (2013)

A scheme to generate a frequency-locked multicarrier based on a complementary frequency shifter (CFS) with double recirculating frequency-shifting loops has been proposed and analyzed theoretically. The transfer function and output properties of a CFS-based multicarrier generator (CMCG) have been derived. Based on our analysis, 100 carriers have been obtained with acceptable flatness under perfect and imperfect operation conditions. The results show that the proposed CMCG can achieve hundreds of frequency-locked carriers used in various scenarios.
Preparing for Managed Competition (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
EVALUATION OF MALARIA SCREENING IN NEWLY ARRIVED REFUGEES TO THE UNITED STATES BY MICROSCOPY AND RAPID ANTIGEN CAPTURE ENZYME ASSAY (2006)

Before an empiric malaria treatment program, >60% of Liberian refugees had malaria on arrival to Minnesota. We compared microscopy with rapid antigen testing for detecting asymptomatic parasitemia. Nine of 103 (8.7%) had malaria by polymerase chain reaction (blood smear and rapid testing had a sensitivity of 22%). The empiric treatment program has decreased the rate of imported asymptomatic malaria. Blood film and rapid antigen testing are poor screening tests.
Boundary element methods for functionally graded materials (2003)

Functionally graded materials (FGMs) possess a smooth variation of material properties due to continuous change in microstructural details. For example, the material gradation may change gradually from a pure ceramic to a pure metal. This work focuses on potential (both steady state and transient) and elasticity problems for inhomogeneous materials. The Green’s function(GF) for these materials (e.g. exponentially graded) are expressed as the GF for the homogeneous material plus additional terms due to material gradation. The numerical implementations are performed using a Galerkin (rather than collocation) approximation. A number of examples have been carried out. The results of some speciflc test problems agree within plotting accuracy with available analytical solutions.
Antioxidant Activity of Saponins Isolated from Ivy: α-Hederin, Hederasaponin-C, Hederacolchiside-E and Hederacolchiside-F (2004)

The antioxidant activities of alpha-hederin and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F from Hedera colchica were investigated, in this study. The antioxidant properties of the saponins were evaluated using different antioxidant tests: 1,1-di-phenyl-2-picryl-hydrazyl (DPPH.) free radical scavenging, total antioxidant activity, reducing power, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. Alpha-hederin, hederasaponin-C, as well as hederacolchisides-E and -F exhibited a strong total antioxidant activity. At the concentration of 75 pg/mL, these saponins showed 94, 86, 88 and 75% inhibition on lipid peroxidation of linoleic acid emulsion,respectively. These various antioxidant activities were compared with model antioxidants such as a-tocopherol, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
Study of device mass production capability of the character projection based electron beam direct writing process technology toward 14 nm node and beyond (2012)

Techniques to appropriately control the key factors for a character projection (CP) based electron beam direct writing technology for mass production are shown and discussed. In order to achieve accurate CD control, the CP technique using the master CP is adopted. Another CP technique, the Packed CP, is used to obtain suitable shot count. For the alignment on the some critical layers which normally have an even surface, the process removing SiO2 material filled in the alignment marks is added and then the alignment marks can be detected using electron beam. The proximity effect correction using the simplified electron energy flux model and the hybrid exposure are used to obtain enough process margins. As a result, the sufficient CD accuracy, overlay accuracy, and yield are obtained on the 65 nm node device. Due to the proper system control, more than 10,000 production wafers have been successfully exposed so far without any major system downtime. It is shown that those techniques can be adapted to the 32 nm node production with slight modifications. It is expected that by using the Multi Column Cell exposure method, those techniques will be applicable to the rapid establishment for the 14 nm node technology.
Hofmeister effect of anions on calcium translocation by sarcoplasmic reticulum Ca2+-ATPase (2015)

The occurrence of Hofmeister (specific ion) effects in various membrane-related physiological processes is well documented. For example the effect of anions on the transport activity of the ion pump Na(+), K(+)-ATPase has been investigated. Here we report on specific anion effects on the ATP-dependent Ca(2+) translocation by the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). Current measurements following ATP concentration jumps on SERCA-containing vesicles adsorbed on solid supported membranes were carried out in the presence of different potassium salts. We found that monovalent anions strongly interfere with ATP-induced Ca(2+) translocation by SERCA, according to their increasing chaotropicity in the Hofmeister series. On the contrary, a significant increase in Ca(2+) translocation was observed in the presence of sulphate. We suggest that the anions can affect the conformational transition between the phosphorylated intermediates E1P and E2P of the SERCA cycle. In particular, the stabilization of the E1P conformation by chaotropic anions seems to be related to their adsorption at the enzyme/water and/or at the membrane/water interface, while the more kosmotropic species affect SERCA conformation and functionality by modifying the hydration layers of the enzyme.
Modulo 2/sup n/ - 1 multiplication / sum-of-squares units (2006)

Several applications profit from the use of a residue number system (RNS). Moduli of the 2/sup n/ - 1 form are among the most commonly used in such systems in which the multiplication and sum-of-squares operations are commonly met. These operations are currently performed using distinct design units and consecutive machine cycles. In this paper, we propose two architectures for modulo 2/sup n/ - 1 units that perform either the X /spl times/ Y or X/sup 2/ + Y/sup 2/ operation depending on the value of a control signal.
Outcomes of Endoscopic Congenital Cholesteatoma Removal in South Korea (2023)

Importance Transcanal endoscopic ear surgery (TEES) provides minimally invasive transcanal access to the middle ear and improves middle ear visibility during cholesteatoma resection. However, the literature on outcomes following TEES alone for the removal of congenital cholesteatoma (CC) is lacking and limited to small series. Objective To assess outcomes of TEES for CC limited to the middle ear and/or mastoid antrum and to explore the risk factors associated with recidivism (ie, recurrent and/or residual cholesteatoma). Design, Setting, and Participants This cohort study evaluated retrospective, multicenter data for 271 children with CC who underwent TEES at 9 tertiary referral hospitals in South Korea between January 1, 2013, and December 31, 2021, and had a follow-up of at least 6 months after surgery. Main Outcomes and Measures Outcomes included the incidence of residual cholesteatoma and audiometric data after TEES. A multivariable analysis using Cox proportional hazards regression models was used to assess associations between cholesteatoma characteristics and recidivism, with hazard ratios (HRs) and 95% CIs reported. Results Of the 271 patients (mean [SD] age, 3.5 [2.9] years; 194 [71.6%] boys, 77 [28.4%] girls), 190 had Potsic stage I CC (70.1%), 21 (7.7%) had stage II, 57 (21.0%) had stage III, and 3 (1.1%) had stage IV. Thirty-six patients (13.3%) with residual cholesteatoma were found, including 15 (7.9%) with Potsic stage I, 3 (14.3%) with stage II, and 18 (31.6%) with stage III. In the multivariable analysis, invasion of the malleus (HR, 2.257; 95% CI, 1.074-4.743) and posterosuperior quadrant location (HR, 3.078; 95% CI, 1.540-6.151) were associated with the incidence of recidivism. Overall, hearing loss (&amp;amp;gt;25 dB on auditory behavioral test or &amp;amp;gt;30 dB of auditory evoked responses) decreased from 24.4% to 17.7% after TEES. Conclusions and Relevance This cohort study involved the largest known population to date of CC removed by TEES. The findings suggest that TEES may be feasible and effective for the removal of CC limited to the middle ear and/or mastoid antrum in children.