gebhart/patrepeval huggingface dataset:
An adaptive approach for uniform scanning in multifocal multiphoton microscopy with a spatial light modulator (2014)

We propose high-quality generation of uniform multiple fluorescence spots (MFS) with a spatial light modulator (SLM) and demonstrate uniform laser scanning in multifocal multiphoton microscopy (MMM). The MFS excitation method iteratively updates a computer-generated hologram (CGH) using correction coefficients to improve the fluorescence intensity distribution in a dye solution whose consistency is uniform. This simple correction method can be applied for calibration of the MMM before observation of living tissue. We experimentally demonstrate an improvement of the uniformity of a 10 × 10 grid of MFS by using a dye solution. After the calibration, we performed laser scanning with two-photon excitation to observe fluorescent polystyrene beads, as well as the gastric gland of a guinea pig specimen.
Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation (2009)

Scribble (Scrib), Discs large, and Lethal giant larvae form a protein complex that regulates different aspects of cell polarization, including apical-basal asymmetry in epithelial cells and anterior-posterior polarity in migrating cells. Here, we show that Scrib interacts with the intermediate filament cytoskeleton in epithelial Madin-Darby canine kidney (MDCK) cells and endothelial human umbilical vein endothelial cells. Scrib binds vimentin via its postsynaptic density 95/disc-large/zona occludens domains and in MDCK cells redistributes from filaments to the plasma membrane during the establishment of cell-cell contacts. RNA interference-mediated silencing of Scrib, vimentin, or both in MDCK cells results in defects in the polarization of the Golgi apparatus during cell migration. Concomitantly, wound healing is delayed due to the loss of directional movement. Furthermore, cell aggregation is dependent on both Scrib and vimentin. The similar phenotypes observed after silencing either Scrib or vimentin support a coordinated role for the two proteins in cell migration and aggregation. Interestingly, silencing of vimentin leads to an increased proteasomal degradation of Scrib. Thus, the upregulation of vimentin expression during epithelial to mesenchymal transitions may stabilize Scrib to promote directed cell migration.
Entanglement transmission over arbitrarily varying quantum channels (2010)

We derive a regularized formula for the common randomness assisted entanglement transmission capacity of finite arbitrarily varying quantum channels (AVQC's). For finite AVQC's with positive capacity for classical message transmission we show, by derandomization through classical forward communication, that the random capacity for entanglement transmission equals the deterministic capacity for entanglement transmission. This is a quantum version of the famous Ahlswede dichotomy. In the infinite case, we derive a similar result for certain classes of AVQC's. At last, we give two possible definitions of symmetrizability of an AVQC.
Diffusion creep of fine‐grained garnetite: Implications for the flow strength of subducting slabs (2000)

Creep experiments were performed on synthetic fine‐grained garnetite to investigate the flow strength of the Earth's subducting slabs. Experiments were conducted at temperatures ( T ) of 1373–1543 K and total pressure ( P ) of 0.1 MPa in controlled atmospheres of f O 2 =10 −17 ‐10 –8 MPa. The mechanical data indicate a grain‐size sensitive diffusion flow and the creep behavior can be described by an equation of the form: where T in Kelvin, d in meter, σ and f O 2 in MPa. Based on the diffusivities ( D ) calculated from creep and diffusion experiments, we proposed that grain boundary diffusion is the dominant mechanism for high temperature creep of the fine‐grained garnetite. Normalized creep strength of the garnetite is found to be comparable to those of feldspar and olivine in diffusion creep regime, suggesting that garnetite may not form a strong layer in the subducted oceanic lithosphere if it deforms by grain boundary diffusion creep.
Biosurfactant and Degradative Enzymes Mediated Crude Oil Degradation by Bacterium Bacillus subtilis A1 (2017)

In this work, the biodegradation of the crude oil by the potential biosurfactant producing <i>Bacillus subtilis</i> A1 was investigated. The isolate had the ability to synthesize degradative enzymes such as alkane hydroxylase and alcohol dehydrogenase at the time of biodegradation of hydrocarbon. The biosurfactant producing conditions were optimized as pH 7.0, temperature 40°C, 2% sucrose and 3% of yeast extract as best carbon and nitrogen sources for maximum production of biosurfactant (4.85 g l<sup>-1</sup>). Specifically, the low molecular weight compounds, i.e., C<sub>10</sub>-C<sub>14</sub> were completely degraded, while C<sub>15</sub>-C<sub>19</sub> were degraded up to 97% from the total hydrocarbon pools. Overall crude oil degradation efficiency of the strain A1 was about 87% within a short period of time (7 days). The accumulated biosurfactant from the biodegradation medium was characterized to be lipopeptide in nature. The strain A1 was found to be more robust than other reported biosurfactant producing bacteria in degradation efficiency of crude oil due to their enzyme production capability and therefore can be used to remove the hydrocarbon pollutants from contaminated environment.
Preselection of the Object Response in a Baseband Pulse Nonlinear Radar (2021)

It is shown that in baseband pulse nonlinear radars a preselector based on the bridge circuits can be used (instead of filter's preselectors in harmonic radars). An original design of the bridge preselector is considered, in which the balun transformer is combined with the magnetic antenna. Based on the simulation results (taking into account a deviation of elements parameters), was obtain that the preselector suppresses the test signal by 46 dB.
Effect of Anterior Callosotomy on Bilaterally Synchronous Spike and Wave and Other EEG Discharges (1994)

We analyzed pre- and postoperative interictal and ictal EEG patterns in relation to seizure outcome in 29 patients with intractable epilepsy who had undergone anterior callosotomy. Twenty-two patients had generalized bilaterally synchronous sharp or spike and slow wave discharges (GSW) and 7 did not: Postoperatively, patients with preoperative GSW showed disruption of synchrony, increased amplitude asymmetry, and a decreased amount of GSW. No significant decrease was noted in the amount of total epileptic discharge after operation. There was a significant relation between seizure outcome and decrease in amount of GSW. The degree of disruption of synchrony, total amount of epileptic discharge, and pre- and postoperative EEG patterns were not good indicators of seizure outcome. Postoperative changes in lateralization of epileptic foci consisted either of increased lateralization, less lateralization but increased independent discharges in the previously nonpredominant hemisphere, or appearance of some lateralization. There appears to be a spectrum of GSW: Both secondary bilateral synchrony and secondarily generalized corticoreticular epileptic discharges are distributed along this spectrum.
A Novel Fiber Bragg Grating Temperature Compensated Strain Sensor (2008)

This paper analyzed the strain-temperature cross sensitive characteristic of optical fiber Bragg grating(FBG) theoretically, designed and made a novel FBG strain sensor. It has a temperature-compensated function, and it improves the effect of being sensitive to strain. To a certain extent, this sensor overcame the traditional temperature-compensated methods easy to have a creep and aged phenomenon. The experimental results show that the sensor realized the temperature sensitivity reduces to 1/10 before the seal, and the strain sensitivity increases to 1.4 pm/uepsiv over the temperature range from -10degC to 50degC .
[Near-infrared fluorescence and energy transfer in Sr2SiO4 : Eu2+, Nd3+]. (2011)

Sr2 SiO4 : Eu2+ , Nd3+ was synthesized by solid state synthesis method, and the sensitization of Nd3+ near-infrared luminescence by Eu2+ was investigated. The characteristic near-infrared luminescence of Nd2+ in Sr2 SiO4 matrix was greatly enhanced by co-doping of Eu2+. The mechanism of energy transfer from Eu2+ to Nd3+ was analyzed through investigation of fluorescence excitation and emission spectra, and fluorescence lifetime. Excited Eu2+ (II) transfers energy effectively to Nd3+ through non-radiative energy transfer process in Sr2SiO4, resulting in greatly enhanced near-infrared luminescence of Nd3+, while sensitization of Nd3+ by Eu2+ (I) was achieved by the way of Eu2+ (II).
High performance heatsinks for processors and power electronics: Beyond extrusions (2002)

Forced air cooling of high density electronics has begun to reach space and weight limits beyond the performance capabilities of standard extrusions. Though extrusions are improving, other manufacturing techniques such as machining, bonded fin, investment casting, folded fin and semi-solid forging provide higher fin densities. When a particular operating condition, such as approach velocity, array velocity, pressure drop, air pumping power or a particular fan curve is fixed, there is an optimum thickness and number of fins for a given heatsink size. In many cases, the optimum design for a heatsink requires a fin density which can only be produced by one of the alternative methods.
Bortezomib, lenalidomide, and dexamethasone (VRd) ± daratumumab (DARA) in patients (pts) with newly diagnosed multiple myeloma (NDMM) for whom transplant is not planned as initial therapy: A multicenter, randomized, phase III study (CEPHEUS). (2019)

TPS8056 Background: DARA is a human, anti-CD38 IgGκ monoclonal antibody that significantly reduced the risk of progression/death with a manageable safety profile across several phase 3 studies in relapsed/refractory MM and NDMM. DARA + VRd (D-VRd) demonstrated efficacy and tolerability in the safety run-in cohort of the ongoing phase 2 GRIFFIN study that included transplant-eligible NDMM pts. To determine whether D-VRd demonstrates efficacy and tolerability in NDMM pts for whom transplant is not intended as initial therapy, the phase 3 CEPHEUS study will evaluate the efficacy and safety of D-VRd vs VRd alone in this pt population. Methods: This is an ongoing multicenter, open-label, randomized phase 3 study of D-VRd vs VRd alone in pts with NDMM for whom transplant is not intended as initial therapy. Approximately 360 pts will be stratified by ISS stage and age/transplant eligibility (age &lt; 70 years and transplant-ineligible, or age &lt; 70 years and refusal to transplant, or age ≥70 years) and will be randomized in a 1:1 ratio. All pts will receive eight 21-day cycles of VRd (V: 1.3 mg/m 2 SC Days 1, 4, 8, 11; R: 25 mg PO Days 1-14; d: 20 mg PO/IV Days 1, 2, 4, 5, 8, 9, 11, 12), followed by 28-day cycles of Rd (R: 25 mg PO Days 1-21; d: 40 mg PO/IV Days 1, 8, 15, 22) until progressive disease (PD). Patients in the DARA group will also receive subcutaneous DARA (1,800 mg co-formulated with recombinant human hyaluronidase PH20 [rHuPH20; Halozyme]) weekly in Cycles 1-2, every 3 weeks in Cycles 3-8, and every 4 weeks in Cycles 9+ until PD. All pts will receive preinfusion medications. Minimal residual disease (MRD)-negative rate at 10 –5 sensitivity threshold by NGS is the primary endpoint. MRD will be evaluated at suspected complete response or better. Secondary endpoints include progression-free survival (PFS), MRD-negative rate at 1-year, durable MRD negativity, overall response rate, time to and duration of response, PFS on next line of therapy, overall survival, clinical efficacy in high-risk molecular subgroups, health-related quality of life, pharmacokinetics, immunogenicity, and safety. Clinical trial information: NCT03652064.
Sera and the in vitro induction of immune responses. I. Bacterial contamination and the generation of good fetal bovine sera. (1975)

More than 200 samples of pooled fetal bovine sera (FBS) were tested to determine their capacity to support primary immune responses by cultured mouse spleen cells. Less than 10% of the FBS samples were fully supportive; the majority of the samples were moderately to very deficient. Several lines of evidence suggest that bacterial contamination during the processing of sera plays a major role in determining which sera are supportive. Serum samples known to have been temporarily contamined during processing were strongly supportive. Samples of FBS which were likely never to have been contaminated were deficient. Bacteria from a specific lot of supportive serum converted a very deficient serum into one which was supportive. Several mechanicsms by which bacteria could effect sera are discussed.
Query Chains: Learning to Rank from Implicit Feedback (2006)

This paper presents a novel approach for using clickthrough data to learn ranked retrieval functions for web search results. We observe that users searching the web often perform a sequence, or chain, of queries with a similar information need. Using query chains, we generate new types of preference judgments from search engine logs, thus taking advantage of user intelligence in reformulating queries. To validate our method we perform a controlled user study comparing generated preference judgments to explicit relevance judgments. We also implemented a real-world search engine to test our approach, using a modified ranking SVM to learn an improved ranking function from preference data. Our results demonstrate significant improvements in the ranking given by the search engine. The learned rankings outperform both a static ranking function, as well as one trained without considering query chains.
Supplementary Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies (2023)

Supplementary Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
A Remote Controlled Valve in Liposomes for Triggered Liposomal Release (2007)

In order to reduce the toxicity and increase the efficacy of drugs, there is a need for smart drug delivery systems. Liposomes are one of the promising tools for this purpose. An ideal liposomal delivery system should be stable, long-circulating, accumulate at the target site and release its drug in a controlled manner. Even though there have been many developments to this end, the dilemma of having a stable liposome during circulation but converting it into a leaky structure at the target site is still a major challenge. So far, most attempts have focused on destabilizing the liposome in response to a specific stimulus at a target site, but with limited success. Our approach is to keep the stable liposome but build in a remote-controlled valve as a new release mechanism, instead. The valve is a pore-forming bacterial membrane protein. It has been engineered such that, after being reconstituted into the liposomes, its opening and closing can be controlled on command by the ambient pH, light or a combination of both. In addition, a much higher degree of flexibility for fine-tuning of the liposome's response to its environment is achieved.
Surface−Enhanced Polymerization via Schiff-Base Coupling at the Solid–Water Interface under pH Control (2015)

On-surface polymerization realized at the solid–liquid interface represents a promising route to obtain stable and conductive organic layers with tunable properties. We present here spectroscopic evidence of π-conjugated polymer formation at the interface between an iodine-modified Au(111) and an aqueous solution. Schiff-base coupling has been used to drive the reaction by changing the pH. Scanning tunneling microscopy (STM) investigations show that the substrate acts as a template driving the formation of 1D ordered nanostructures. All the chemical states of the molecules on the surface have been identified and their evolution as a function of the pH has been monitored by synchrotron radiation X-ray photoelectron spectroscopy (XPS), demonstrating that two polymeric phases, undistinguishable by STM, exist on the surface: intermediate state and π-conjugated final product. The I/Au(111) substrate enhances the formation of π-conjugated polymers, as established comparing their production on the surface and in the bulk solution.
Digital Simulation and Experimental Validation of Redox Mediation at an Electroactive Monolayer-Coated Electrode (2020)

A commercial digital simulation tool was used to simulate cyclic voltammetry (CV) data for redox mediation electrode reactions involving immobilized redox mediators. The system studied consists of a ferrocene-based redox mediator in an alkanethiolate-based self-assembled monolayer (SAM) on gold, with ferrocyanide in solution acting as electron donor to react with electrogenerated ferrocenium in the monolayer. Simulation parameters include rate constants for ferrocene oxidation/reduction in the monolayer, the mediation cross reaction between ferrocenium in the monolayer and ferrocyanide in solution, and the direct (unmediated) ferrocyanide oxidation/reduction reaction by long-range electron transfer across the monolayer. An excellent agreement between simulation and experiment was obtained using simulation parameters derived from independent experiments. The simulation method enables analysis of an entire voltammogram which can offer advantages over analytical approaches that consider only a portion of the data (e.g., a “foot-of-the-wave” analysis). The availability of a validated simulation tool allows questions about the anticipated reactivity of immobilized redox mediators to be addressed definitively via simulation, rather than by speculation on the effects one might expect to observe on a CV waveshape for a particular parameter change.
Self management of rate, power and carrier-sense threshold for interference mitigation in IEEE 802.11 networks (2014)

Nowadays, it is common to find IEEE 802.11 networks that are deployed in an unplanned and unmanaged manner. Moreover, because of the low hardware cost and, trying to obtain better coverage and performance, a large number of devices are usually installed in reduced spaces causing high-density deployments. This kind of networks experiment several problems related with the shared nature of the transmission medium. In recent years, different transmit power control mechanisms have been proposed to palliate those problems, however, in some situations, the existing solutions can lead to an starvation problem. In this paper, we present a novel mechanism that manages data rate, transmit power and carrier-sense threshold to reduce this problem.
ChemInform Abstract: CRYSTAL STRUCTURE OF NA2BASI2O6 (1974)

Abstract Die Titelverbindung kristallisiert monoklin mit der Raumgruppe P2 1 und a = 11,440, b = 4,758, c = 5,670 Å, β = 91,42°, Z=2.
Some Recollections of Trevor West MRIA (2013)

Robin E. Harte, Finbarr Holland, Lothrop Mittenthal, Roger Smyth, Richard M. Timoney, SOME RECOLLECTIONS OF TREVOR WEST MRIA, Mathematical Proceedings of the Royal Irish Academy, Vol. 113A, No. 2 (DECEMBER 2013), pp. iii-xx
Method to validate relative spectral response curves (1998)

A methodology for validating the measured relative spectral response function of infrared detectors is described. Typically, the spectral response of sister detectors, fabricated on the same wafer as the detectors for infrared focal plane arrays (IRFPA's), are characterized in lieu of measuring the spectral response of the actual IRFPA. It is then generally assumed that the spectral characteristics of the IRFPA detectors are equivalent to the spectral characteristics of the sister detectors. To validate this assumption, a measurement methodology has been developed to assess the accuracy the measured relative spectral response curves. This methodology is based on the premise that infrared detector's measured peak responsivity is independent of the spectral content of the irradiance at the detector. The peak wavelength responsivity of the infrared detector is measured as a function of spectral photon irradiance to evaluate the accuracy of the measured detector relative spectral response. If the measured peak responsivity of the infrared detector is independent of spectral irradiance, then the measured spectral response accurately represents the spectral characteristics of the infrared detector. However, if the peak responsivity varies with spectral irradiance, then the measured spectral response is in error. The shape of the peak responsivity versus spectral irradiance curve provides insight into the spectral region where the measured spectral response is in error. Sample relative spectral response data are presented along with analysis of the spectral response curves.
Biodegradable Glass Material (Bgm): A Potential Bone Graft Adjunct/Substitute (1984)

Bone grafting is an important clinical procedure and although fresh cancellous autografts are preferred, certain drawbacks exist (Brown and Cruess, 1982; Friedlaender, 1982). In particular, the amount of autograft that can be harvested may be insufficient and its collection necessitates creation of a bone defect at the donor site. For these reasons, allografts are often resorted to but they are inferior and their histocompatibility must be considered (Brown and Cruess, 1982; Bos et al., 1983). Xenografts have been used with variable success and recently their efficacy has been questioned (McMurray, 1982).KeywordsBone DefectKIRSCHNER WireFoam GlassL929 Mouse FibroblastHealing Bone DefectThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
A blister-like soft nano-textured thermo-pneumatic actuator as an artificial muscle (2018)

Here, model blister-like soft thermo-pneumatic artificial muscles with the embedded nanofibers impregnated with ethanol are developed. The muscles are essentially blister-like thermo-pneumatic soft actuators (BTSAs), which deflect in response to heat supplied to their bottom. The resulting deflections are on the scale of 1 cm, and the BTSAs are operational for several cycles. They are able to raise the artificial rigid scales, spines or fur/thin fibers attached to them emulating animals such as pangolin, hedgehog and porcupine. They are also capable of removing the stickiest adhesive tapes attached to them, and thus hold great promise for biomedical applications where artificially grown skin patches should be removed from an underlying substrate without being damaged. The theory of the BTSA proposed in this work is in reasonable agreement with the acquired experimental data.
The Herschel-Heterodyne Instrument for the Far-Infrared (HIFI): instrument and pre-launch testing (2008)

This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI), to be launched onboard of ESA's Herschel Space Observatory, by 2008. It includes the first results from the instrument level tests. The instrument is designed to be electronically tuneable over a wide and continuous frequency range in the Far Infrared, with velocity resolutions better than 0.1 km/s with a high sensitivity. This will enable detailed investigations of a wide variety of astronomical sources, ranging from solar system objects, star formation regions to nuclei of galaxies. The instrument comprises 5 frequency bands covering 480-1150 GHz with SIS mixers and a sixth dual frequency band, for the 1410-1910 GHz range, with Hot Electron Bolometer Mixers (HEB). The Local Oscillator (LO) subsystem consists of a dedicated Ka-band synthesizer followed by 7 times 2 chains of frequency multipliers, 2 chains for each frequency band. A pair of Auto-Correlators and a pair of Acousto-Optic spectrometers process the two IF signals from the dual-polarization front-ends to provide instantaneous frequency coverage of 4 GHz, with a set of resolutions (140 kHz to 1 MHz), better than < 0.1 km/s. After a successful qualification program, the flight instrument was delivered and entered the testing phase at satellite level. We will also report on the pre-flight test and calibration results together with the expected in-flight performance.