gebhart/patrepeval huggingface dataset:
The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways (2002)

There is substantial evidence of increased platelet reactivity in vivo and in vitro during pregnancy, with the risk of developing pre-eclampsia. In this study, platelet function was studied during 28-40 weeks of gestation in a group of women who remained normotensive and in a group of nonpregnant female controls. Platelet aggregation stimulated by thrombin and adenosine diphosphate was markedly enhanced in washed platelets from pregnant subjects. Thrombin (0.04 U/ml)-evoked increases in intracellular Ca+2 mobilization of Fura 2-AM-loaded platelets were also enhanced in pregnant subjects. The binding of fluorescein isothiocyanate (FITC)-triflavin (2 microg/ml) to the glycoprotein IIb/IIIa complex in thrombin-activated platelets did not differ significantly between the nonpregnant and pregnant groups. Thromboxane A2 (TXA2) formation in both resting and thrombin-activated platelets from pregnant subjects was significantly greater than from nonpregnant subjects. Levels of cyclic adenosine monophosphate (cAMP) in both resting and prostaglandin E1-treated platelets (10 micromol/l) from pregnant subjects were significantly lower than those from nonpregnant subjects. There were no significant differences between nonpregnant and pregnant subjects in platelet cAMP levels in the presence of imidazole (600 micromol/l) and indomethacin (500 micromol/l). Intracellular pH values in platelets were measured spectrofluorometrically using the fluorescent probe, BCECF-AM. The increase in intracellular pH stimulated by thrombin (0.04 U/ml) in pregnant subjects was markedly greater than that in observed nonpregnant subjects. We conclude that the agonist-induced hyperaggregability of platelets in normal pregnancy may be due, at least partly, to stimulation of the Na+/H+ exchanger and subsequently to elevated intracellular Ca+2 mobilization, and then to increased TXA2 formation and a lowered level of cAMP, which leads to further increases in intracellular Ca+2 mobilization, and finally to enhanced platelet aggregation.
Capacitive Deionization: Rapid Inversion of Surface Charges in Heteroatom‐Doped Porous Carbon: A Route to Robust Electrochemical Desalination (Adv. Funct. Mater. 9/2020) (2020)

In article number 1909387, Jeyong Yoon, Yung-Eun Sung, and co-workers report capacitive deionization using heteroatom-doped porous carbons prepared from coffee waste. The presence of nitrogen and sulfur dopants lead to rapid inversion of surface charges in the carbonaceous electrodes during desalination, which leads to high performance and stability. Roles of the dopants are revealed by diverse electrochemical and synchrotron-based X-ray analyses.
Five 1D to 3D Zn(ii)/Mn(ii)-CPs based on dicarboxyphenyl-terpyridine ligand: stepwise adsorptivity and magnetic properties (2017)

Five coordination polymers with different dimensional structures have been solvothermally synthesized by utilizing H<sub>2</sub>dtp ligand. Complexes<bold>1</bold>and<bold>2</bold>reveal strong solid-state luminescence, and complexes<bold>3–5</bold>display antiferromagnetic exchange.
Data from cAMP-Mediated Autophagy Promotes Cell Survival via ROS-Induced Activation of PARP1: Implications for Treatment of Acute Lymphoblastic Leukemia (2023)

&lt;div&gt;Abstract&lt;p&gt;DNA-damaging therapy is the basis for treatment of most cancers, including B-cell precursor acute lymphoblastic leukemia (BCP-ALL, hereafter ALL). We have previously shown that cAMP-activating factors present in the bone marrow render ALL cells less sensitive to DNA damage–induced apoptosis, by enhancing autophagy and suppressing p53. To sensitize ALL cells to DNA-damaging therapy, we have searched for novel targets that may counteract the effects induced by cAMP signaling. In the current study, we have identified PARP1 as a potential target. We show that the PARP1 inhibitors olaparib or PJ34 inhibit cAMP-mediated autophagy and thereby potentiate the DNA-damaging treatment. Furthermore, we reveal that cAMP-mediated PARP1 activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events. Accordingly, we demonstrate that scavenging ROS by N-acetylcysteine and repleting NAD independently reduce DNA damage-induced autophagy. In addition, olaparib augmented the effect of DNA-damaging treatment in a human xenograft model of ALL in NOD-&lt;i&gt;scid&lt;/i&gt;IL2Rgamma&lt;sup&gt;null&lt;/sup&gt; mice. On the basis of the current findings, we suggest that PARP1 inhibitors may enhance the efficiency of conventional genotoxic therapies and thereby provide a novel treatment strategy for pediatric patients with ALL.&lt;/p&gt;Implications:&lt;p&gt;PARP1 inhibitors augment the DNA damage–induced killing of ALL cells by limiting the opposing effects of cAMP-mediated autophagy, which involves ROS-induced PARP1 activation and depletion of cellular NAD levels.&lt;/p&gt;&lt;/div&gt;
Colloidal Lock-and-Key Dimerization Reactions of Hard Annular Sector Particles Controlled by Osmotic Pressure (2015)

Colloidal annular sectors are a broad class of shapes that offer the interesting possibility of dimerization when osmotically compressed to high densities while undergoing Brownian motion in two dimensions (2D). Here, we lithographically create and form a stable aqueous dispersion of many microscale prismatic 270° annular sectors, and we explore their near-equilibrium behavior in a tilted 2D gravitational column. Near the top of the column where the 2D gravitational osmotic pressure Π(2D) is low, we observe a gas-like phase composed almost entirely of monomers. However, below the surface and deeper into the column where Π(2D) is higher, we observe a reaction zone where monomers and dimers coexist, followed by an arrested region containing a very high percentage of interpenetrating, lock-and-key dimers that are a racemic mixture of positive and negative chiralities. We determine particle area fractions of monomers and dimers as a function of depth and use these to obtain the system's 2D osmotic equation of state. In the reaction zone, where dimers transiently form and break up, we also use these to calculate the equilibrium constant K associated with the monomer-dimer reaction, which increases exponentially with Π(2D). This dependence can be attributed the reduction in number of accessible microstates for dimers as they become more tightly compressed.
Recruitment of damselfishes in One Tree Island lagoon: persistent interannual spatial patterns (2000)

The spatial and temporal patterns of distribution of new settlers of 23 species of damselfish (Pomacentridae) within One Tree Island lagoon, southern Great Barrier Reef (GBR) were measured for 3 summers to assess the persistence of spatial patterns of recruitment. Overall recruitment was 3 times higher in 1993/1994 than 1994/1995, and 1.5 times higher than 1999. In general, recruitment decreased towards the lagoon centre, even though habitat availability was not lower there on average, suggesting that most fish settled at outer sites as they were advected from adjacent waters. There was also great variation in numbers of recruits among outer sites. Patterns of recruitment to continuous reef and patch reef habitats also differed among species, suggesting habitat selection at this broad level. For example, Pomacentrus nagasakiensis was primarily found on patch reefs, while P. moluccensis was largely found on continuous reef. One site (Shark Alley) received the highest number of recruits of most species during the study, and this pattern has been observed in studies since 1975. Despite interannual variability in abundance of potential settlers and differences in the habitat preferences of some species, therefore, some sites on the reef can receive relatively high numbers of settlers over decadal time scales. This consistency of spatial pattern may be due to local topography and oceanography at Shark Alley, which appear to favour the input of potential settlers. The availability of live coral may also be important, but species which showed no preferences for live cover also recruited at high levels at this site. The attributes of Shark Alley were compared with those at other sites. Overall, sites that clustered on the basis of oceanographic and habitat features also had similar recruitment, suggesting that these features may be useful in predicting recruitment hotspots on reefs elsewhere.
Modificaciones de las poblaciones linfocitarias tras cirugia en pacientes neoplasicos y no neoplasicos (1997)

OBJETIVOS: 1. Determinar las modificaciones que produce la cirugia sobre las subpoblaciones de linfocitos CD4, CD8, CD29 y CD45RA. 2. Determinar si el efecto de la cirugia sobre estas subpoblaciones difiere en dos grupos de pacientes: uno con patologia benigna y otra con patologia maligna. MATERIAL Y METODOS: 87 pacientes, 40 hombres y 47 mujeres, de los que 56 presentaban patologia benigna y 31 patologia maligna. A todos ellos se les realizaron dos extracciones de sangre: una inmediatamente antes de la intervencion y otra a las 24 horas de iniciada la misma. CONCLUSIONES: 1. Despues de la cirugia disminuyen los linfocitos CD4, CD3, CD29 y CD45RA. 2. No hemos encontrado diferencias estadisticamente significativos de las modificaciones que se producen en las subpoblaciones linfocitarias, entre pacientes con patologia benigna y con patologia maligna. 3. La disminucion de los linfocitos CD4 que se produce despues de las intervenciones quirurgicas esta relacionado con la concentracion preoperatoria de transferrina y con el valor preoperatorio de linfocitos CD4. 5. No hemos encontrado correlacion entre el descenso de linfocitos y el aumento de la concentracion de cortisol.
Synthesis of 8,9‐dialkoxybenzodiazepines and 7,8‐dialkoxyisoquinolines (2006)

Abstract magnified image o ‐Aroylarylacetone type 1,5‐diketone derivatives (5, 6) were synthesised from arylacetones (1) protected as 1,3‐dioxolanes (4) through directed ortho lithiation followed by acylation with aroyl chlorides. 8,9‐Dialkoxy‐2,3‐benzodiazepines 9 were obtained by cyclisation of diketones 6 with hydrazine. The reaction of diketones 6 with ammonia gave 7,8‐dialkoxyisoquinolines 11. Reaction of ketals 5 with hydrazine hydrochloride and hydroxylamine hydrochloride afforded N ‐amino‐7,8‐dialkoxyisoquinolinium chlorides (10) and 7,8‐dialkoxyisoquinolinium oxides (12), respectively.
Adsorption rate and protective effect of tributyl(cyclohexyl)ammonium chloride inhibitor on the acidic corrosion of steel (2009)

Abstract The inhibition of corrosion of a steel surface by an inhibitor, tributyl(cyclohexyl)ammonium chloride (TBCA), was investigated by gravimetric and electrochemical polarization measurements in various aqueous solutions of HCl and H 2 SO 4 acids. It is known that the most extensive corrosive destruction proceeds during the initial stage of contact between the metallic surface and the aggressive surroundings. The change from H 2 SO 4 to HCl considerably decreases the time for formation of an adsorption layer. The high adsorption of the surface‐active cationic TBCA on the steel electrode surface can be explained by the specific adsorption of Cl − anions increasing the negative charge on the electrode surface. It was observed that the value of the polarizing current can be increased from time to time by addition of more TBCA inhibitor. This fact can be explained by the low stability of the film‐forming layer on the steel. A similar decrease of the protective effect was also observed in HCl solution. The inhibitor provides at least a slowing of the corrosion process ( τ = 21 min). It was found that an increase in H 2 SO 4 concentration from 1.0 to 0.2 N did not change the protective action of the inhibitor and had rather high values ( θ = 283 ma/h, ψ = 84%, and τ = 14 min at [I] = 3.5 × 10 −4 mol/L). It was shown that the attraction constant has a negative value ( A = −1.5 and K a = 22.3) for the inhibitor, which relates to a high value for the adsorption ability of TBCA in HCl solution and therefore with the intermolecular repulsive force between adsorption molecules having similar charges. The protective action of TBCA increases with an increase in temperature, which is correlated with the chemical nature of its adsorption on the steel surface.
Photoproduction of Hydrogen by Decamethylruthenocene Combined with Electrochemical Recycling (2017)

Abstract The photoinduced hydrogen evolution reaction (HER) by decamethylruthenocene, Cp 2 *Ru II (Cp*=C 5 Me 5 ), is reported. The use of a metallocene to photoproduce hydrogen is presented as an alternative strategy to reduce protons without involving an additional photosensitizer. The mechanism was investigated by (spectro)electrochemical and spectroscopic (UV/Vis and 1 H NMR) measurements. The photoactivated hydride involved was characterized spectroscopically and the resulting [Cp 2 *Ru III ] + species was electrochemically regenerated in situ on a fluorinated tin oxide electrode surface. A promising internal quantum yield of 25 % was obtained. Optimal experimental conditions— especially the use of weakly coordinating solvent and counterions—are discussed.
Characteristics of the high density plasma production by m=0 helicon wave (1996)

The characteristics of the high density plasma production by the m = 0 azimuthal mode helicon wave is investigated. By varying the power of the applied radio frequency Prf two discharge modes exist; one is the low density mode (plasma density np&amp;lt;1012 cm−3), at which the discharge is sustained not by a helicon wave but by the antenna induction field at low Prf; the other is the high density mode (np≳1013 cm−3), in which helicon wave is excited at high Prf; in between the two modes, np jumps more than an order of magnitude. The threshold Prf for the density jump is higher for the m = 0 mode than that of the m = +1 and −1 modes excited by the helical antenna.
Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells (2017)

Hibernators show superior resistance to ischemia and hypothermia, also outside the hibernation season. Therefore, hibernation is a promising strategy to decrease cellular damage in a variety of fields, such as organ transplantation. Here, we explored the role of mitochondria herein, by comparing epithelial cell lines from a hibernator (hamster kidney cells, HaK) and a non-hibernator (human embryonic kidney cells, HEK293) during cold preservation at 4 °C and rewarming. Cell survival (Neutral Red), ATP and MDA levels, mitochondrial membrane potential (MMP), mitochondrial morphology (using fluorescent probes) and metabolism (seahorse XF) were assessed. Hypothermia induced dispersion of the tubular mitochondrial network, a loss of MMP, increased oxygen radical (MDA) and decreased ATP production in HEK293. In contrast, HaK maintained MMP and ATP production without an increase in oxygen radicals during cooling and rewarming, resulting in superior cell survival compared to HEK293. Further, normothermic HaK showed a dispersed mitochondrial network and higher respiratory and glycolysis capacity compared to HEK293. Disclosing the mechanisms that hibernators use to counteract cell death in hypothermic and ischemic circumstances may help to eventually improve organ preservation in a variety of fields, including organ transplantation.
Prediction of molecular dipole moments from bond moments: testing of the method by DFT calculations on isolated molecules (2004)

The well-known principle of vector addition of bond moments, used as standard approximation when interpreting and predicting the experimental dipole moments, has been now checked on the calculated moments of isolated molecules with the accuracy not attainable by measurements in solution. Chloro derivatives of adamantane 1a–3a and 1,4-derivatives of bicyclo[2.2.2]octane 4–16 were used as model compounds: their dipole moments were calculated at the levels B3LYP/6-311+G(d,p) and B3LYP/AUG-cc-pVTZ//B3LYP/6-311+G(d,p). In the case of two collinear dipoles, the resulting dipole moments were always slightly greater than the additive values but the additive approximation would be sufficient for practical purposes. The small difference can be explained by mutual induction of the two dipoles and can be roughly estimated by simple electrostatic calculation in spite of several uncertain parameters. The same applies to the adamantane derivatives 2a and 3a, in agreement with previous experiments in solution. In the case of the unsymmetrical CH2Cl groups in bicyclooctane derivatives 13–16, the additive values are always too great since the group moment does not lie exactly in the C–Cl bond. Nevertheless, the principle of vector addition can be used even in this case when an empirically determined group moment is used instead of a bond moment. Summarizing, the vector addition of bond moments is not exact theoretically but can be used rather broadly with a precision comparable to the accuracy of the experimental dipole moments estimated from solution measurements.
Antenna bandwidth optimization for gaming applications (2011)

The design of an aperture-coupled, dual polarized patch antenna on a small-size FR-4 substrate with a convenient tuning technique is proposed. This technique allows the antenna's impedance bandwidth to be adjusted to fit the desired frequency application. This design is applied to a gaming console to establish a wireless link between a console and a controller. The use of FR-4 substrate allows the manufacturing costs related to mass circuit production to be significantly reduced. Although the size of the antenna is smaller than standard patch antennas operating at a desired frequency, the performance criteria such as gain, efficiency and broadside radiation are not compromised. The measured results show that a maximum bandwidth greater than 7% can be obtained.
Tier 1, Teacher-Implemented Self-Regulated Strategy Development for Students With and Without Behavioral Challenges (2012)

This study took place in the context of schools collaborating with a local university to implement an evidence-based, 3-tiered model of prevention and supports targeting academic, behavioral, and social goals. We examined whether Self-Regulated Strategy Development (SRSD) instruction, delivered by grade 2 and 3 general education teachers to all students (Tier 1), would improve story or opinion essay writing among students with and without behavioral challenges, and whether differential effects existed. SRSD instruction was effective for both groups of students in terms of genre elements and quality. Students without challenging behaviors made greater gains than those with challenging behaviors on some outcome measures. Teachers implemented SRSD with fidelity; SRSD was viewed as socially valid by teachers and students. No results were found for academic engaged time or overall level of behavioral problems. Finally, students' cognitive capabilities were a weak and inconsistent predictor of SRSD writing gains.
Optimization for Biogas Power Plants using Automatic Control of Gas Pressures (2013)

In many cases, gas storages on biogas power plants are not used optimally to store gas as much as their capacity. The digester is sometimes overload to store gas and the controller cannot deliver gas to other storage. Consequently, gas is often released from digester to avoid over pressure. At the end, biogas power plant has less efficiency. Hence, a mechanism to control gas pressure to make different pressure between its storages is required. Fans were used to manipulate the most majority system pressures on a biogas power plant using frequency converters. Measurements, simulations, and experiments were conducted to create a new system on a biogas power plant. A controller, Programmable Logic Controller was used to control the entire system pressure using Proportional-Integral-Derivative algorithm. When the gas pressures are not in the allowable range of pressure, then the controller changes the fans’ frequency to the desired conditions. As a result, gas moves to another storage and system pressures are in the allowable range.
QoS routing through alternate paths in wireless ad hoc networks: Research Articles (2004)

Quality of service (QoS) routing plays an important role in QoS provisioning for mobile ad hoc networks. This work studies the issue of route selection subject to QoS constraint(s). Our method searches for alternate routes with satisfied QoS requirement(s) to accommodate each communication request when the shortest path connecting the source–destination pair of the request is not qualified. In order to effectively reduce protocol overhead, a directed search mechanism is designed to limit the breadth of the searching scope, which aims at achieving a graceful tradeoff between the success probability in QoS route acquisition and communication overhead. Efficient hop-by-hop routing protocols are designed for route selection subject to delay and bandwidth constraint, respectively. Simulation results show that the designed protocols can achieve high performance in acquiring QoS paths and in efficient resource utilization with low control overhead. Copyright © 2004 John Wiley & Sons, Ltd.
Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis (2017)

A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significance to oncogenesis or prognosis. Here, we report that FOXP1-SHQ1 deletion cooperates with PTEN loss to accelerate prostate oncogenesis and that loss of component genes correlates with prostate, breast, and head and neck cancer recurrence. We demonstrate that Foxp1-Shq1 deletion accelerates prostate tumorigenesis in mice in combination with Pten loss, consistent with the association of FOXP1-SHQ1 and PTEN loss observed in human cancers. Tumors with combined Foxp1-Shq1 and Pten deletion show increased proliferation and anaplastic dedifferentiation, as well as mTORC1 hyperactivation with reduced Akt phosphorylation. Foxp1-Shq1 deletion restores expression of AR target genes repressed in tumors with Pten loss, circumventing PI3K-mediated repression of the androgen axis. Moreover, FOXP1-SHQ1 deletion has prognostic relevance, with cancer recurrence associated with combined loss of PTEN and FOXP1-SHQ1 genes.