gebhart/patrepeval huggingface dataset:
Association of adriamycin‐induced resistance to NK‐mediated lysis with sialic acid level and immunological reactivity of transferrin receptors and glycophorin A (1988)

Adriamycin (ADM) can increase sialic acid content in K 562 cells and reduce their susceptibility to NK-mediated lysis. In this report, hypothetical relationship between this resistance and augmentation in sialylation has been investigated. Variations in the time of exposure to ADM showed that 12 hours were sufficient to cause maximal recruitment of benzidine-positive cells, growth inhibition and resistance to NK-mediated lysis. On the contrary, the membrane sialic acid density seemed stable and 24 hours of drug exposure were necessary to observe a clear rise in sialic acid. Neuraminidase treatment of control and ADM-treated K 562 cells was associated with an obvious enhancement in their susceptibility to NK-mediated lysis which can be explained by an increase in the target-effector binding ability as assessed by a direct conjugate-forming cell assay. However, the neuraminidase treatment did not modify the sensitivity difference to lysis between untreated and ADM-treated cells. As compared to control the reactivity of ADM-treated cells was higher with an antiglycophorin A (GPA) MAb and lower with an antitransferrin receptor (TFR) MAb. Kinetic studies suggested that GPA expression is a better index of ADM-induced resistance to NK-mediated lysis than TFR expression. In addition, neuraminidase treatment showed that TFR and GPA modulations induced by ADM can be correlated with sialylation alterations.
The microbiome of the esophagus, stomach and duodenum in patients with gastroesophageal reflux disease - pilot study (2020)

Introduction: These days gastroesophageal reflux disease (GERD) represents one of the significant health problems of western countries as a result of several lifestyle factors. Prolonged GERD leads to esophageal inflammation and significantly increases the risk of Barrett’s esophagus (BE) and the subsequent development of esophageal adenocarcinoma (EAC). There is an association between the esophageal microbiome and several esophageal diseases. However, it remains unclear whether the change in microflora leads to esophageal disease, or if this is a side effect of the highly acidic environment created by GERD. Our pilot study aimed to describe oral bacterial biota in patients with GERD and healthy controls from different parts of the esophagus, stomach and duodenum. Detailed microbiome analysis could contribute to early diagnosis and to the application of effective treatment in patients with GERD.
High-sensitivity material systems for two-photon three dimensional microfabrication (2004)

A photoacid generator (PAG) is described that can be efficiently activated by two-photon excitation and can be used for high-sensitivity three-dimensional micro-patterning of acid-sensitive media. The molecule has been specifically engineered to have both a large peak two-photon absorption cross section (δ= 690 × 10-50 cm4 s photon-1 at 705 nm) and a high quantum yield for the photochemical generation of acid (φH+ ≈ 0.5). Under near-infrared laser irradiation, the PAG produces acid subsequent to two-photon excitation and initiates the polymerization of epoxides. The PAG was used in conjunction with the epoxide resist SU-8 for negative-tone three-dimensional microfabrication and was incorporated into a specially formulated chemically amplified resist for positive-tone fabrication of a three-dimensional grating structure. These material systems expand the potential of three-dimensional microfabrication as a tool for manufacturing micro-electromechanical systems, micro-fluidics, and micro-optical structures.
Instrumental texture evaluation of extruded snack foods: a review (2007)

"Extrusion cooking technology is the most used technique for the production of snack foods. In such foods, texture isof major importance, with crispness being often a desirable attribute. Due to the high costs involved in sensory analysis,instrumental assessment of end-product texture, by fundamental and empirical techniques, has been a useful tool for foodresearchers and manufactures as it has been related to sensory evaluation. Among other tests, the texture analysis of expandedsnacks has been performed through compression, penetration, acoustic procedures and texture profile analysis. Althoughthis review has focused in instrumental techniques, texture evaluation of extruded snacks is a complex subject, where thecombination of techniques involving sensory, instrumental and microstructure analysis would certainly be the best practice.From a practical perspective, empirical methods are suggested as an alternative to fundamental techniques, especially tofood scientists and food manufactures interested in predict consumer perception of texture."
COVID-19 pandemic in France (2020)

Coronavirus Coronavirus disease 2019 (COVID-19) exacted a heavy toll in France during March and April 2020. Quarantine measures were effective in reducing transmission by 84%, and some relaxation of social isolation was expected in May. Salje et al. fit transmission models for the epidemic in France to hospital admissions. The authors forecast that 2.9 million people will have been infected by 11 May, representing 4.4% of the population—a value inadequate for herd immunity. Daily critical care hospitalizations should reduce from several hundreds to tens of cases, but control will remain a delicate balancing act. Any relaxation of lockdown in France will have to be carefully controlled and monitored to avoid undermining more optimistic forecasts. Science , this issue p. [208][1] [1]: /lookup/doi/10.1126/science.abc3517
Nonlinear Energy Harvesting (2009)

Ambient energy harvesting has been in recent years the recurring object of a number of research efforts aimed at providing an autonomous solution to the powering of small-scale electronic mobile devices. Among the different solutions, vibration energy harvesting has played a major role due to the almost universal presence of mechanical vibrations. Here we propose a new method based on the exploitation of the dynamical features of stochastic nonlinear oscillators. Such a method is shown to outperform standard linear oscillators and to overcome some of the most severe limitations of present approaches. We demonstrate the superior performances of this method by applying it to piezoelectric energy harvesting from ambient vibration.
HEV system EMC investigation during transient operations (2007)

EMC challenges for hybrid electric vehicles have been published and shown to have dependencies on high slew rates coupled with parasitic impedances from electric machines, high voltage cables, heat sinks, circuit layout considerations, and the alike. Although the steady state operation of power converters creates apparent EMC disturbances, it doesn’t always create a worst case scenario. Transient operation of the system, such as load torque and speed gradients, can cause additional disturbances that are rarely covered and become difficult to analyze. This paper covers these transient operational issues evaluating them in time, frequency, and time-frequency domain.
When Does Non-Negative Matrix Factorization Give a Correct Decomposition into Parts? (2004)

We interpret non-negative matrix factorization geometrically, as the problem of finding a simplicial cone which contains a cloud of data points and which is contained in the positive orthant. We show that under certain conditions, basically requiring that some of the data are spread across the faces of the positive orthant, there is a unique such simplicial cone. We give examples of synthetic image articulation databases which obey these conditions; these require separated support and factorial sampling. For such databases there is a generative model in terms of "parts" and NMF correctly identifies the "parts". We show that our theoretical results are predictive of the performance of published NMF code, by running the published algorithms on one of our synthetic image articulation databases.
A combined spectroscopic and plasma chemical kinetic analysis of ionospheric samarium releases (2017)

Two rocket-borne releases of samarium vapor in the upper atmosphere occurred in May 2013, as part of the Metal Oxide Space Clouds experiment. The releases were characterized by a combination of optical and RF diagnostic instruments located at the Roi-Namur launch site and surrounding islands and atolls. The evolution of the optical spectrum of the solar-illuminated cloud was recorded with a spectrograph covering a 400-800 nm spectral range. The spectra exhibit two distinct spectral regions centered at 496 and 636 nm within which the relative intensities change insignificantly. The ratio between the integrated intensities within these regions, however, changes with time, suggesting that they are associated with different species. With the help of an equilibrium plasma spectral model we attribute the region centered at 496 nm to neutral samarium atoms (Sm I radiance) and features peaking at 649 nm to a molecular species. No evidence for structure due to Sm + (Sm II) is identified. The persistence of the Sm I radiance suggests a high dissociative recombination rate for the chemi-ionization product, SmO + . A one-dimensional plasma chemical kinetic model of the evolution of the density ratio N SmO /N Sm (t) demonstrates that the molecular feature peaking at 649 nm can be attributed to SmO radiance. SmO + radiance is not identified. By adjusting the Sm vapor mass of the chemical kinetic model input to match the evolution of the total electron density determined by ionosonde data, we conclude that less than 5% of the payload samarium was vaporized.
Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2 *2 gene allele (2009)

These results indicate that acetaldehyde, rather than ethanol or acetate, is primarily responsible for the observed alcohol sensitivity reactions in heterozygotic alcoholics and suggest that physiological tolerance and/or innate low sensitivity may play a crucial role in overcoming the deterring response. A potential pharmacogenetic classification of acetaldehydism and alcoholism for alcoholics carrying the different ALDH2 genotypes is proposed.
RETRACTED: Anti-cancer effects of polyphenol-rich sugarcane extract (2021)

Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung cancer (A549), human ovarian cancer (SKOV-3), pro-monocytic human leukemia (U937) and to mouse melanoma (B16) cell lines; whereas no effects were noted on human breast (ZR-75-1) and human colon (HT29) cancer cell lines, as well as to human normal colon epithelial cell line (T4056). Anti-proliferative effects were shown to be mediated via alteration in cytokines, VEGF-1 and NF-κB expression.
A Clinical Study of Quazepam in Hospitalized Patients with Insomnia (1981)

The efficacy of quazepam (Sch-16134) 15 mg capsules as a hypnotic has been compared with that of placebo in a 9-day study, using a parallel-group design. The physician's global evaluation numerically favoured quazepam 63% (nineteen of thirty) over placebo 50% (fifteen of thirty). Furthermore, it demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern (2005)

The extent and patterns of linkage disequilibrium (LD) determine the feasibility of association studies to map genes that underlie complex traits. Here we present a comparison of the patterns of LD across four major human populations (African-American, Caucasian, Chinese, and Japanese) with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22. We constructed metric LD maps formulated such that the units measure the extent of useful LD for association mapping. LD reaches almost twice as far in chromosome 6 as in chromosomes 21 or 22, in agreement with their differences in recombination rates. By all measures used, out-of-Africa populations showed over a third more LD than African-Americans, highlighting the role of the population's demography in shaping the patterns of LD. Despite those differences, the long-range contour of the LD maps is remarkably similar across the four populations, presumably reflecting common localization of recombination hot spots. Our results have practical implications for the rational design and selection of SNPs for disease association studies.
Electronic Metamaterials with Tunable Second-order Optical Nonlinearities (2017)

The ability to engineer metamaterials with tunable nonlinear optical properties is crucial for nonlinear optics. Traditionally, metals have been employed to enhance nonlinear optical interactions through field localization. Here, inspired by the electronic properties of materials, we introduce and demonstrate experimentally an asymmetric metal-semiconductor-metal (MSM) metamaterial that exhibits a large and electronically tunable effective second-order optical susceptibility (χ<sup>(2)</sup>). The induced χ<sup>(2)</sup> originates from the interaction between the third-order optical susceptibility of the semiconductor (χ<sup>(3)</sup>) with the engineered internal electric field resulting from the two metals possessing dissimilar work function at its interfaces. We demonstrate a five times larger second-harmonic intensity from the MSM metamaterial, compared to contributions from its constituents with electrically tunable nonlinear coefficient ranging from 2.8 to 15.6 pm/V. Spatial patterning of one of the metals on the semiconductor demonstrates tunable nonlinear diffraction, paving the way for all-optical spatial signal processing with space-invariant and -variant nonlinear impulse response.
Sparse Approximation via Generating Point Sets (2019)

For a set P of n points in the unit ball b⊆ R d , consider the problem of finding a small subset T ⊆ P such that its convex-hull ε-approximates the convex-hull of the original set. Specifically, the Hausdorff distance between the convex hull of T and the convex hull of P should be at most ε. We present an efficient algorithm to compute such an ε′-approximation of size k alg , where ε ′ is a function of ε and k alg is a function of the minimum size k opt of such an ε-approximation. Surprisingly, there is no dependence on the dimension d in either of the bounds. Furthermore, every point of P can be ε-approximated by a convex-combination of points of T that is O (1/ε 2 )-sparse. Our result can be viewed as a method for sparse, convex autoencoding: approximately representing the data in a compact way using sparse combinations of a small subset T of the original data. The new algorithm can be kernelized, and it preserves sparsity in the original input.
BİR REALİST HALK HİKÂYESİ: HİKÂYE-İ MANSÛR (2018)

Halk edebiyatında çoğunlukla büyük hacimli halk hikâyeleri üzerinde çalışmalar yapılırken küçük hacimli halk hikâyeleri üzerine yeterli çalışmaların yapılmadığı görülmektedir. Bu bakımdan küçük hacimli bu tarz eserlerin günümüz alfabesine aktarımı, Türk halk hikâyesi geleneğinin zenginliğini ortaya koyması bakımından oldukça önem taşımaktadır. Bu çalışmada; bugüne kadar yayımlanmamış ve üzerinde çalışma yapılmamış olan “Hikâye-i Mansûr” adlı eserin metin neşri yapılmıştır. Öncelikle hikâyenin kısa bir özeti verilmiştir. Daha sonra ise eserin nüshaları hakkında bilgi verilmiş ve hikâyenin türüyle ilgili çeşitli değerlendirmelerde bulunulmuştur. Çalışmanın sonunda Latin alfabesine aktarılmış olan eserin aktarılmış metni yer almaktadır. Küçük hacimli bir hikâye olan Hikâye-i Mansûr’un iki el yazması ve üç matbu olmak üzere beş nüshası vardır. Matbu nüshalar, el yazması nüshalardan aynen istinsah edilmiştir. Nüshaların aynı olması ve el yazması nüshada görülen bazı okuma güçlüklerinden dolayı Latin alfabesine yapılan aktarımda matbu nüsha esas alınmıştır. Hikâye; tek bir olay etrafında gelişen ve Mansur adlı kahramanın başından geçen çeşitli maceraları konu alan realist bir hikâye niteliği taşımaktadır. Hikâye kahramanı Mansur, olayları kendi dilinden anlatmaktadır. Hikâye, Hindistan’ın Mahe ve Kalikut gibi bazı şehirlerinde geçmektedir. Bu hikâyedeki Mansur, tasavvufi bir kişilik olan Hallac-ı Mansur değildir. Zira metnini neşrettiğimiz bu hikâye dini bir nitelik taşımaz.
Cooperative Structural Dynamics and a Novel Fidelity Mechanism in Histidyl-tRNA Synthetases (1999)

The crystal structure of the Staphylococcus aureus histidyl-tRNA synthetase apoprotein has been determined at 2.7 A resolution. Several important loops in the active site either become disordered or adopt very different conformations compared to their ligand-bound states. These include the histidine A motif (Arg257-Tyr262) that is essential for substrate recognition, a loop (Gly52-Lys62) that seems to control the communication between the histidine and ATP binding sites, the motif 2 loop (Glu114-Arg120) that binds ATP, and the insertion domain that is likely to bind tRNA. These ligand-induced structural changes are supported by fluorescence experiments, which also suggest highly cooperative dynamics. A dynamic and cooperative active site is most likely necessary for the proper functioning of the histidyl-tRNA synthetase, and suggests a novel mechanism for improving charging fidelity.
2‐Alkyl‐3‐(1,2,3,6‐tetrahydropyridin‐4‐yl)‐1H‐indoles as Novel 5‐HT6 Receptor Agonists. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice (2009)

The present study provides morphological and molecular biological evidence for the protective role of the antioxidant vitamins E and ABT in ameliorating oxidative stress, hepatic apoptosis, and necroinflammation in experimental nutritional steatohepatitis.
Deficient mastication and type of pasta modify in vitro oral and intestinal starch digestibility (2021)

International audience
Preparative-scale matrix isolation: application to the direct synthesis of binary metal carbonyls using metal atomic reagents (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparative-scale matrix isolation: application to the direct synthesis of binary metal carbonyls using metal atomic reagentsJohn Godber, Helmut X. Huber, and Geoffrey A. OzinCite this: Inorg. Chem. 1986, 25, 16, 2909–2910Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ic00236a052https://doi.org/10.1021/ic00236a052research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Organometallics in Synthesis (1994)

Keywords: Synthesis (a manual on organometallics in synthesis); Organometallic compounds Role: RCT (Reactant) ; RACT (Reactant or reagent) (a manual on organometallics in synthesis) ; book organometallic compd synthesis Note: CAN 122:56197 29-1 Organometallic and Organometalloidal Compounds UK. Book written in English. Reference LSCO-BOOK-1994-001 Record created on 2006-03-03, modified on 2016-08-08
Modeling and Characterization of the Effects of Field Gradients on the Behavior of Ferroelectrics With Interdigitated Electrodes (2013)

Macro fiber composites (MFCs) are used in applications ranging from sensing and actuation to energy harvesting and piezoelectric damping. MFCs are comprised of interdigitated electrodes (IDEs) on ferroelectric fibers that result in anisotropic in plane sensing and actuation capability. Minor hysteresis loops were measured for a MFC and the area within the minor hysteresis loops was used to assess material loss under unipolar cyclic loading. A separate set of minor hysteresis loops was run on a fully electroded plate of the same material to determine the material loss when the electric field was uniform. The MFC displayed considerably more material loss than the uniformly loaded plate. A micromechanical model implemented in a finite element code was used to model the effect of inhomogeneous fields, local stress, and polarization reorientation on the dielectric losses. The results indicate that the development of local stress in the ferroelectric material beneath the inerdigitated electrodes results in ferroelastic polarization reorientation that contributes to dielectric losses.
Detection of methylation status of Epstein‐Barr virus DNA C promoter in the diagnosis of nasopharyngeal carcinoma (2019)

The detection of Epstein-Barr virus (EBV) DNA load in nasopharyngeal (NP) brushing samples for diagnosis of nasopharyngeal carcinoma (NPC) has attracted great attention. Further improvements that eliminate the need for clinical settings will greatly extend its application. A total of 250 participants were recruited to obtain NP brushing samples. Brush sampling both with and without the guide of endoscopy was conducted in 38 NPC patients. EBV DNA load, EBV RNA transcript and EBV DNA C promoter methylation status were, respectively, evaluated. Typical latency II transcripts were observed in brushing samples from NPC patients but not controls. Unlike in tissues, multiple lytic gene transcripts were observed not only in NPC patients but also in controls. Apart from EBV RNA transcript, samples from NPC patients also showed higher levels of EBV DNA load and C promoter methylation degree than their controls. Qualitative analysis further showed that EBV DNA C promoter was methylated in all NPC patients but in only 18.4% of the control group. Combined analysis of EBV DNA methylated degree and EBV DNA load increased the sensitivity to 100% in the detection of NPC. Using qualitative methylated type as the criteria, up to 89.5% of samples collected via blind brushing showed consistent results with samples collected via endoscopy-guided brushing from NPC patients. Detection of the methylation status of EBV DNA C promoter in NP brushing samples shows great potential in diagnosing NPC and may provide an appealing alternative for the non-invasive detection and screening of NPC without the need for clinical settings.