gebhart/patrepeval huggingface dataset:
Entrepreneurial innovation in chains and networks in Dutch greenhouse horticulture (2005)

This paper focuses on the critical success factors in entrepreneurial innovation, and the role of cooperation with chain partners, knowledge institutions and colleague firms in the Dutch glasshouse industry. This industry, typified by a large number of family-owned entrepreneurial firms, is generally acknowledged as one of the world leaders in horticultural production and trade. Not only are the auctions of Aalsmeer and Naaldwijk among the most important horticultural auctions in the world, but the knowledge of cultivation techniques is also highly developed in the Netherlands. In order to maintain its leading position and to compete successfully with low-cost countries, Dutch horticulture is constantly reinventing itself. If we take a closer look, however, we see that only a limited number (3%) of the Dutch glasshouse companies actually take the lead in innovation. Using expert advice, we selected the 74 most successful innovative companies to be included in this study, of which 44 companies were willing to participate. In 2004, all the participating companies were visited. In total 139 innovations were analysed, using a combination of half-structured in-depth interviews with the glasshouse entrepreneurs and a structured questionnaire based on 10-point Likert scales. The entrepreneurs were asked to fill out the questionnaire for their most and least successful innovations. As expected, more successful (87) than failed innovations (52) were reported. Our results show that the characteristics demonstrated by the innovative entrepreneurs are essential for success in innovation. The innovative entrepreneur has a strategic vision of how to serve the market and create value. Also, team communication was extremely important. Successful entrepreneurs maintain an open atmosphere and show real commitment to the innovation process. They are in contact with a diverse network of business relations to develop innovations. Intensifying the network relations, e.g. by clustering glasshouse companies, leads to more successful innovation. The more firms in the horticultural production chain were actively involved in the innovation process, the bigger the chances of success. This was especially true for firms downstream toward the market.
Associating synchronization constraints with data in an object-oriented language (2006)

Concurrency-related bugs may happen when multiple threads access shared data and interleave in ways that do not correspond to any sequential execution. Their absence is not guaranteed by the traditional notion of "data race" freedom. We present a new definition of data races in terms of 11 problematic interleaving scenarios, and prove that it is complete by showing that any execution not exhibiting these scenarios is serializable for a chosen set of locations. Our definition subsumes the traditional definition of a data race as well as high-level data races such as stale-value errors and inconsistent views. We also propose a language feature called atomic sets of locations, which lets programmers specify the existence of consistency properties between fields in objects, without specifying the properties themselves. We use static analysis to automatically infer those points in the code where synchronization is needed to avoid data races under our new definition. An important benefit of this approach is that, in general, far fewer annotations are required than is the case with existing approaches such as synchronized blocks or atomic sections. Our implementation successfully inferred the appropriate synchronization for a significant subset of Java's Standard Collections framework.
Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Co-Transporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice (2021)

We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose, kidney injury and sodium-glucose co-transporter 2 (Sglt2) expression in diabetic Akita &lt;i&gt;Nrf2&lt;/i&gt;&lt;sup&gt;-/-&lt;/sup&gt;/&lt;i&gt;Nrf2&lt;sup&gt;RPTC&lt;/sup&gt;&lt;/i&gt; transgenic (Tg) mice. Immortalized human RPTCs (HK2) stably transfected with plasmid containing the &lt;i&gt;SGLT2&lt;/i&gt; promoter, human kidneys from patients with diabetes were also studied. Nrf2 overexpression was associated with increased blood glucose, glomerular filtration rate, urinary albumin-creatinine ratio, tubulointerstitial fibrosis and Sglt2 expression in Akita &lt;i&gt;Nrf2&lt;/i&gt;&lt;sup&gt;-/-&lt;/sup&gt;/&lt;i&gt;Nrf2&lt;sup&gt;RPTC&lt;/sup&gt;&lt;/i&gt; Tg mice compared to their Akita &lt;i&gt;Nrf2&lt;/i&gt;&lt;sup&gt;-/-&lt;/sup&gt; littermates. &lt;i&gt;In vitro&lt;/i&gt;, oltipraz or transfection of &lt;i&gt;NRF2&lt;/i&gt; cDNA stimulated SGLT2 expression and &lt;i&gt;SGLT2&lt;/i&gt; promoter activity in HK2, and these effects were inhibited by trigonelline or &lt;i&gt;NRF2 &lt;/i&gt;small interfering RNA. The deletion of the &lt;i&gt;NRF2&lt;/i&gt;-&lt;i&gt;responsive element (NRF2-RE)&lt;/i&gt; in the &lt;i&gt;SGLT2&lt;/i&gt; promoter abolished the stimulatory effect of oltipraz on &lt;i&gt;SGLT2 &lt;/i&gt;promoter activity. NRF2 binding to the &lt;i&gt;NRF2&lt;/i&gt;-&lt;i&gt;RE&lt;/i&gt; of the &lt;i&gt;SGLT2&lt;/i&gt; promoter was confirmed by gel mobility shift assay and chromatin immunoprecipitation assays. Kidneys from patients with diabetes exhibited higher levels of NRF2 and SGLT2 in the RPTCs than kidneys from patients without diabetes. These results suggest a link by which NRF2 mediates hyperglycemia-stimulation of SGLT2 expression and exacerbates blood glucose and kidney injury in diabetes.
Initial Experiences of Building Secure Access to Patient Confidential Data via the Internet (2000)

A project to enable health care professionals (GPs, practice nurses and diabetes nurse specialists) to access, via the Internet, confidential patient data held on a secondary care (hospital) diabetes information system, has been implemented. We describe the application that we chose to distribute (a diabetes register); the security mechanisms we used to protect the data (a public key infrastructure with strong encryption and digitally signed messages, plus a firewall); the reasons for the implementation decisions we made; the validation testing that we performed and the preliminary results of the pilot implementation.
Influence of printing speed on production of embossing tools using fdM 3d printing technology (2017)

Manufacturing of the embossing tools customary implies use of metals such as zinc, magnesium, copper, and brass. In the case of short run lengths, a conventional manufacturing process and the material itself represent a significant cost, not only in the terms of material costs and the need for using complex technological systems which are necessary for their production, but also in the terms of the production time. Alternatively, 3D printing can be used for manufacturing similar embossing tools with major savings in production time and costs. However, due to properties of materials used in the 3D printing technology, expected results of embossing by 3D printed tools cannot be identical to metal ones. This problem is emphasized in the case of long run lengths and high accuracy requirement for embossed elements. The objective of this paper is primarily focused on investigating the influence of the printing speed on reproduction quality of the embossing tools printed with FDM (Fused Deposition Modelling) technology. The obtained results confirmed that printing speed as a process parameter affects the reproduction quality of the embossing tools printed with FDM technology: in the case of deposition rate of 90 mm/s was noted the poorest dimensional accuracy in relation to the 3D model, which is more emphasised in case of circular and square elements. Elements printed with the highest printing speed have a greater dimensional accuracy, but with evident cracks on the surface.
Umstellung auf iGlarLixi gegenüber der weitergeführten Behandlung mit einem GLP-1-Rezeptoragonisten bei unzureichend kontrolliertem Typ-2-Diabetes: die randomisierte LixiLan-G-Studie (2021)

Hintergrund iGlarLixi ist eine titrierbare Fixkombination von Insulin glargin 100 E / ml und dem GLP-1-Rezeptoragonist (GLP-1-RA) Lixisenatid. Die hier vorgestellte Studie verglich die Umstellung auf iGlarLixi mit der Fortführung der bestehenden GLP-1-RA-Behandlung, beide mit oralen Antidiabetika, über 26 Wochen bei Menschen mit unkontrolliertem Typ-2-Diabetes. Zudem wurden Sicherheit und Wirksamkeit von iGlarLixi über 52 Wochen untersucht.
Family 28 carbohydrate-binding module of the thermostable endo-1,4-β-glucanase CelD from Caldicellulosiruptor bescii maximizes enzyme activity and irreversibly binds to amorphous cellulose (2013)

The nucleotide sequence of a chromosome fragment of the thermophilic anaerobic bacterium Caldicellulosiruptor bescii (syn. Anaerocellum thermophilum) has been determined. The fragment contains four open reading frames with the second encoding a 749 aa multimodular endo-1,4-β-glucanase CelD (85019 Da). The N-terminal region of the protein includes a signal peptide and a catalytic module of glycoside hydrolase family 5 (GH5), followed by a carbohydrate-binding module of family 28 (CBM28). The C-terminal region bears three SLH modules. The recombinant endoglucanase and its two separate modules, the catalytic module and CBM28, were produced in E. coli cells and purified to homogeneity. An analysis of the catalytic properties showed CelD to be an endo-1,4-β-glucanase with maximum activity on barley β-glucan at pH 6.2 and 70°C. The enzyme was stable at 50°C for 30 days. Upon removal of the C-terminal CBM28, the activity of GH5 was decreased on cellulose substrates, and its thermostability has dropped. Binding of CBM28 to amorphous cellulose has been almost irreversible as it could not be removed from this substrate in a range of pH of 4–11, temperatures of 0–75°C, and NaCl concentrations of 0–5 M. Only 100% formamide or 1% SDS have been able to remove the protein.
High-density optical storage using arsenic nanoclusters in GaAs and AlGaAs (1992)

A novel GaAs-based photorefractive thin-film material with ultrashort transport lengths has been developed. This material consists of As nanoclusters in a high-quality GaAs matrix, denoted GaAs:As. The As clusters act as quantum antidots which exclude the wavefunctions of the electrons and holes. The resulting reduced space of the carrier wavefunctions results in quantum-confined excitons in the GaAs regions between the As clusters. Therefore, GaAs:As exhibits a large electrooptic effect at room temperature for photon energies close to the bandgap. This large electrooptic effect, along with charge trapping on the As clusters, provides a high-density holographic storage medium. The ultrafast lifetimes of the photogenerated carriers due to the As clusters produce excellent spatial resolution during writing of holographic space-charge gratings. Fringe spacings as small as 600 nm were supported in GaAs:As, yielding a volume optical data density greater than 10/sup 12 /b/cm/sup 3/.
Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro (2015)

Auto-transplant of cryopreserved ovarian tissue in leukemia patients carries a risk to reintroduce malignant cells. Maturation of ovarian follicles in vitro is a promising strategy to overcome the leukemic cell contamination. The follicle development and survival in 14 cryopreserved ovarian tissues with leukemia-specific PCR marker was evaluated after 7 or 14 days culture. Minimal residual disease (MRD) quantification was assessed by real-time quantitative PCR in order to identify the MRD positive (n = 6) and negative (n = 8) samples and to monitor levels of MRD before and after culture. The morphology of ovarian follicles were studied by light microscopy. After culture, no statistical significant differences were detected in follicle densities between MRD positive- and negative samples. Ovarian MRD either decreased below undetectable or fluctuated near the baseline level after 7 and 14 days in culture. This study provides quantitative in vitro evidence that leukemia contamination does not affect the follicle survival in cryopreserved ovarian tissue.
MICROBRIDGE METHOD DETERMINING THE MECHANICAL PROPERTIES OF LOW STRESS LPCVD SILICON NITRIDE FILM AND ITS ERROR ANALYSIS (2003)

2003-2004 > Academic research: refereed > Publication in refereed journal
SignalGuru: Leveraging mobile phones for collaborative traffic signal schedule advisory (2011)

While traffic signals are necessary to safely control competing flows of traffic, they inevitably enforce a stop-and-go movement pattern that increases fuel consumption, reduces traffic flow and causes traffic jams. These side effects can be alleviated by providing drivers and their onboard computational devices (e.g., vehicle computer, smartphone) with information about the schedule of the traffic signals ahead. Based on when the signal ahead will turn green, drivers can then adjust speed so as to avoid coming to a complete halt. Such information is called Green Light Optimal Speed Advisory (GLOSA). Alternatively, the onboard computational device may suggest an efficient detour that will save the driver from stops and long waits at red lights ahead. This paper introduces and evaluates SignalGuru, a novel software service that relies solely on a collection of mobile phones to detect and predict the traffic signal schedule, enabling GLOSA and other novel applications. Our SignalGuru leverages windshieldmounted phones to opportunistically detect current traffic signals with their cameras, collaboratively communicate and learn traffic signal schedule patterns, and predict their future schedule. Results from two deployments of SignalGuru, using iPhones in cars in Cambridge (MA, USA) and Singapore, show that traffic signal schedules can be predicted accurately. On average, SignalGuru comes within 0.66s, for pre-timed traffic signals and within 2.45s, for traffic-adaptive traffic signals. Feeding SignalGuru’s predicted traffic schedule to our GLOSA application, our vehicle fuel consumption measurements show savings of 20.3%, on average.
Using vector sensors to measure the complex acoustic intensity field (2015)

The acoustic intensity vector field, defined as the product of pressure particle velocity fields, describes the flow of energy from an acoustic source. Following a brief introduction of acoustic vector sensors, which includes some direct measurements of acoustic intensity, the intensity field is shown to be composed of active and reactive components. Active intensity streamlines depict the time-averaged flow of acoustic energy and reveal characteristics of acoustic propagation including environmental influences. These streamlines do not characterize reactive intensity, which corresponds to the portion of acoustic intensity that time-averages to zero. Reactive intensity is significant in the near-field of a source and in environments where multipath interfere occurs. To examine the interplay between active and reactive acoustic intensity, the acoustic field generated by an airborne source positioned well above a water surface is presented. Acoustic measurements of a passing airplanes, made simultaneously above and below this sea-surface, are used to demonstrate properties of active and reactive intensity, including how reactive intensity can serve as an indicator of source altitude and range.
1998 Guidance, Navigation, and Control Highlights (1998)

This article summarizes the highlights of recent events and developments in guidance, navigation, and control in space, aircraft, and weapons. This article is about 1,200 words long. Information for the article was collected from other NASA centers, DoD, and industry. All information was previously cleared by the originating organizations. Information for the article was also gathered from Aviation Week and Space Technology, Space News, and similar sources.
Homogeneous Assay for Whole Blood Folate Using Photon Upconversion (2014)

Red blood cell folate is measured for folate deficiency diagnosis, because it reflects the long-term folate level in tissues, whereas serum folate only represents the dietary intake. Direct homogeneous assay from whole blood would be ideal but conventional fluorescence techniques in blood suffer from high background and strong absorption of light at ultraviolet and visible wavelengths. In this study, a new photon upconversion-based homogeneous assay for whole blood folate is introduced based on resonance energy transfer from upconverting nanophosphor donor coated with folate binding protein to a near-infrared fluorescent acceptor dye conjugated to folate analogue. The sensitized acceptor emission is measured at 740 nm upon 980 nm excitation. Thus, optically transparent wavelengths are utilized for both donor excitation and sensitized acceptor emission to minimize the sample absorption, and anti-Stokes detection completely eliminates the Stokes-shifted autofluorescence. The IC50 value of the assay was 6.0 nM and the limit of detection (LOD) was 1 nM. The measurable concentration range was 2 orders of magnitude between 1.0-100 nM, corresponding to 40-4000 nM folate in the whole blood sample. Recoveries of added folic acid were 112%-114%. A good correlation was found when compared to a competitive heterogeneous assay based on the DELFIA-technology. The introduced assay provides a simple and fast method for whole blood folate measurement.
A Redefinition of Odor Mixture Quality. (2005)

Odor mixtures are perceived as different from (configural) or the same as (elemental) their components. Recent studies (L. M. Kay, C. A. Lowry, & H. A. Jacobs, 2003; C. Wiltrout, S. Dogra, & C. Linster, 2003) propose that component structural or perceptual similarities predict configural properties of binary mixtures. The authors evaluated this in rats using 4 binary mixtures with varying structural similarity (eucalyptol-benzaldehyde, eugenol-benzaldehyde, octanol-octanal, and [+/-]-limonene). The range of tested ratios for each mixture was determined by the components' vapor pressures. Three results are presented: (a) No mixture maintains purely elemental or configural properties for all concentration ratios, (b) structural similarity or dissimilarity does not predict configural or elemental perception, and (c) overshadowing is significant in responses to all odor sets. The authors offer more precise definitions of elemental and configural properties and overshadowing as they relate to odor mixture perception.
A Multiview Face Identification Model With No Geometric Constraints (2006)

Face identification systems relying on local descriptors are increasingly used because of their perceived robustness with respect to occlusions and to global geometrical deformations. Descriptors of this type - based on a set of oriented Gaussian derivative filters - are used in our identification system. In this paper, we explore a pose-invariant multiview face identification system that does not use explicit geometrical information. The basic idea of the approach is to find discriminant features to describe a face across different views. A boosting procedure is used to select features out of a large feature pool of local features collected from the positive training examples. We describe experiments on well-known, though small, face databases with excellent recognition rate
3D Stochastic Stratigraphic Well Correlation of Carbonate Ramp Systems (2009)

This reference is for an abstract only. A full paper was not submitted for this conference. 1) Introduction In the static and dynamic workflow of carbonate reservoirs, stratigraphic correlation of well data is one of the first and most influent steps. Indeed, facies distribution and petrophysical properties mainly control flow simulation and are often computed thanks to geostatistical methods, on grids based on stratigraphic correlation and structural data interpreted from seismic data (Borgomano [2008]). In reservoir uncertainty modeling approaches, a unique grid is built, and uncertainties about layering geometry, facies distribution and petrophysical properties are handled using multiple geostatistical simulations (Charles et al, 2001). This article aims at assessing uncertainties due to stratigraphic correlations by also generating several set of possible stratigraphic well correlations. Several grids may then be built from these results and used for facies and property modeling. The method presented here generates automatically and stochastically sequence stratigraphic correlations of carbonate ramp systems by hierarchically integrating multiple pieces of 3D information as: interpreted well data,correlation lines extracted from seismic, andinformation obtained on analogs. 2) 3D Stochastic Stratigraphic Well Correlation method To perform the correlation, we propose a multi-dimensional and stochastic extension of the Dynamic Time Warping Algorithm (DTW, Myers et al., 1981) that we call msDTW. The DTW algorithm provides a way to find the optimal alignment between two time series [Myer et al., 1981]. This algorithm was used for the correlation of two wells by Smith and Waterman [1980], Howell [1983], Waterman and Raymond [1987], Griffiths and Bake [1990], Brown [1997] for example. Lallier et al. [2009] presented an improvement of the DTW, making the method stochastic and introducing a hierarchy to mimic the reasoning made by sedimentologists when correlating well data (Fig. 1), and applied this method to a carbonate ramp system.
Blood-brain barrier dysfunction promotes astrocyte senescence through albumin-induced TGFβ signaling activation (2022)

Abstract Blood-brain barrier dysfunction (BBBD) and accumulation of senescent astrocytes occur during brain aging and contribute to neuroinflammation and disease. Here, we explored the relationship between these two age-related events, hypothesizing that chronic hippocampal exposure to the blood-borne protein serum albumin could induce stress-induced premature senescence (SIPS) in astrocytes via transforming growth factor beta 1 (TGFβ) signaling. We found that one week of albumin exposure significantly increased TGFβ1 and senescence marker expression in cultured rat hippocampal astrocytes. These changes were preventable by pharmacological inhibition of the type I TGFβ receptor (TGFβR) ALK5. To study these effects in vivo , we utilized an animal model of BBBD in which albumin was continuously infused into the lateral ventricles of adult mice. Consistent with our in vitro results, one week of albumin infusion significantly increased TGFβ signaling activation and the burden of senescent astrocytes in hippocampal tissue. Pharmacological inhibition of TGFβR ALK5 or conditional genetic knockdown of astrocytic TGFβR prior to albumin infusion was sufficient to prevent albumin-induced astrocyte senescence. Together, these results establish a link between TGFβ signaling activation and astrocyte senescence and suggest that prolonged exposure to serum albumin due to BBBD can trigger these phenotypic changes.