gebhart/patrepeval huggingface dataset:
Design and Synthesis of Cabazitaxel Loaded Core‐Shell Mesoporous Silica Nanoparticles with Different Morphologies for Prostate Cancer Therapy (2023)

In this work, the synthesis of core-shell ordered mesoporous silica nanoparticles (CSMS) with tunable particle size and shape through a dual surfactant-assisted approach is demonstrated. By varying the synthesis conditions, including the type of the solvent and the concentration of the surfactant, monodispersed and ordered mesoporous silica nanoparticles with tunable particle size (140-600 nm) and morphologies (hexagonal prism (HP), oblong, spherical, and hollow-core) can be realized. Comparative studies of the Cabazitaxel (CBZ)-loaded HP and spherical-shaped CSMS are conducted to evaluate their drug delivery efficiency to PC3 (prostate cancer) cell lines. These nanoparticles showed good biocompatibility and displayed a faster drug release at acidic pH than at basic pH. The cellular uptake of CSMS measured using confocal microscopy, flow cytometry, microplate reader, and ICP-MS (inductively coupled plasma mass spectrometry) techniques in PC3 cell lines revealed a better uptake of CSMS with HP morphology than its spherical counterparts. Cytotoxicity study showed that the anticancer activity of CBZ is improved with a higher free radical production when loaded onto CSMS. These unique materials with tunable morphology can serve as an excellent drug delivery system and will have potential applications for treating various cancers.
RNA-Protein-Interaktion im Rampenlicht (2009)

Recent preclinical evidence suggests that leptin may modulate the stress response and may increase nociception. In this study, we examined for the first time the extent to which cigarette smoking is associated with leptin levels during an extended rest period and in response to noxious stimuli. Repeated blood samples were collected during a laboratory session from smokers and nonsmokers and assayed for leptin. Pain experiences, as well as neuroendocrine and cardiovascular measures, were collected across cold pressor and thermal heat pain tests. Both analysis of variance and correlations confirmed that smokers demonstrated dysregulations in leptin responsivity and association with pain relative to nonsmokers. The flat pattern of leptin release and the weak associations of this hormone with pain in smokers suggest a long-term effect of tobacco dependence on this regulatory hormone. In light of leptin's influence on reward pathways, further investigation of leptin's involvement in nicotine dependence is warranted.
Professional continuous glucose monitoring in patients with diabetes mellitus: A systematic review and meta‐analysis (2023)

In patients with type 1 and type 2 diabetes, p-CGM-driven care is superior to usual care in improving glucose control without increasing hypoglycaemia.
The indirect binary n-cube array (1977)

The array is built from a large number (hundreds or thousands) of microprocessors or microcomputers linked through a switching network into an indirect binary n-cube array. Control is two level, the array operating synchronously, or in lock step, at the higher level, and with the broadcast commands being locally interpreted into rewritable microinstruction streams in the microprocessors and in the switch control units. The key to the design is the switching array. By properly programming it, the array can be made into a wide variety of virtual arrays which are well adapted to a wide range of applications. It is believed that the flexibility of the switching array can be used to obtain fault avoidance, which appears necessary in any highly parallel design.
Displacement of the Sustentacular Fragment in Intra-Articular Calcaneal Fractures (2013)

Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Norovirus Disease in the United States (2013)

Although recognized as the leading cause of epidemic acute gastroenteritis across all age groups, norovirus has remained poorly characterized with respect to its endemic disease incidence. Use of different methods, including attributable proportion extrapolation, population-based surveillance, and indirect modeling, in several recent studies has considerably improved norovirus disease incidence estimates for the United States. Norovirus causes an average of 570-800 deaths, 56,000-71,000 hospitalizations, 400,000 emergency department visits, 1.7-1.9 million outpatient visits, and 19-21 million total illnesses per year. Persons >65 years of age are at greatest risk for norovirus-associated death, and children <5 years of age have the highest rates of norovirus-associated medical care visits. Endemic norovirus disease occurs year round but exhibits a pronounced winter peak and increases by ≤ 50% during years in which pandemic strains emerge. These findings support continued development and targeting of appropriate interventions, including vaccines, for norovirus disease.
(Probably) Concave Graph Matching (2018)

In this paper we address the graph matching problem. Following the recent works of \cite{zaslavskiy2009path,Vestner2017} we analyze and generalize the idea of concave relaxations. We introduce the concepts of conditionally concave and probably conditionally concave energies on polytopes and show that they encapsulate many instances of the graph matching problem, including matching Euclidean graphs and graphs on surfaces. We further prove that local minima of probably conditionally concave energies on general matching polytopes (e.g., doubly stochastic) are with high probability extreme points of the matching polytope (e.g., permutations).
A Controlled Trial of Povidone–Iodine as Prophylaxis against Ophthalmia Neonatorum (1995)

A 2.5 percent ophthalmic solution of povidone-iodine as prophylaxis against ophthalmia neonatorum is more effective than treatment with silver nitrate or erythromycin, and it is less toxic and costs less.
Prolongation of Transgene Expression by Coexpression of Cytokine Response Modifier A in Rodent Liver after Adenoviral Gene Transfer (2002)

The short duration of expression of the transgenes is a major barrier to the clinical application of adenovirus-mediated gene therapy for hepatic enzyme deficiencies. Previous reports show that Fas-mediated apoptosis has a pivotal role in the rapid elimination of adenovirus-infected hepatocytes. After considering this result and our recent observation that murine hepatocytes can be protected from Fas-mediated apoptosis by expressing cytokine response modifier A (CrmA) in vivo, we hypothesized that CrmA coexpression could also prevent adenovirus-infected hepatocytes from rapid elimination and that this would make prolonged transgene expression achievable in vivo. To examine this, mice with congenital deficiency of lysosomal beta-glucuronidase (GUSB) were infected with recombinant adenoviruses expressing both CrmA and GUSB, and the duration of transgene expression was evaluated. The serum GUSB activity in the mice injected with a recombinant adenovirus expressing GUSB only became undetectable 60 days after the injection, whereas higher than normal GUSB activity was observed for at least 120 days in mice injected with adenoviruses expressing both GUSB and CrmA. Furthermore, we showed that exogenous CrmA expression could prevent the adenovirus-infected hepatocytes from cell death induced by cytotoxic T lymphocytes in vitro. These observations indicate that transgene expression after administration of E1-deleted adenovirus is prolonged by coexpression of the antiapoptotic protein CrmA.
Concept of Hybridization of the Automobile (2011)

Evolution of present day engine-propelled automobiles over many years is discussed. Importance of load resistance is noted. Drive cycles influence the vehicle fuel economy and propulsion requirements, and their importance is emphasized. Load and engine characteristics are indicated graphically to emphasize how they come into picture. Meaning of load is clearly defined. A summarized discussion and comparison of various types of systems, i.e. pure electric, hybrid, plug-in hybrid, and fuel cell vehicles are made. Constituent elements and system level architectures relevant to these vehicles are also discussed. Logical process of evolution from conventional to hybrid vehicles is slowly brought forth.
Assisted Reproductive Techniques for Cattle Breeding in Developing Countries: A Critical Appraisal of Their Value and Limitations (2011)

Commercialization of animal biotechnologies, including those related to reproduction [also known as assisted reproductive techniques (ARTS)], is an increasing reality in developing countries, following the enormous flow of information around us and the increasing global commercial interests in areas where cattle production has its major assets. The present review discusses the achievements of various biotechnological tools for reproduction in cattle including semen handling for artificial insemination (AI), superovulation and embryo transfer (MOET), in vitro handling of oocytes and production of embryos, reproductive cloning and emerging technologies (sex selection, gene targeting and nuclear transfer for livestock transgenesis, genomics for marker-assisted selection, etc.). The application of these technologies for cattle breeding is critically discussed in relation to their impact in the improvement of the efficiency of dairy and beef production in developed and - particularly - in developing countries, which ultimately rule the possibilities of a competitive and sound production of food for human consumption. Despite the remarkable progress made and the punctual importance of some of the above-mentioned technologies, AI remains the most important assisted reproductive technology (ART) in developing countries. Any attempt to gain widespread of any other ART under the predominant economical conditions in developing countries ought to match the simplicity and the success of AI as a breeding tool.
The Charge Plasma n-p-n Impact Ionization MOS on FDSOI Technology: Proposal and Analysis (2016)

In this paper, we propose the charge plasma n-p-n impact ionization MOS (I-MOS) on a lightly doped p-type silicon film using the charge plasma concept. The performance of the proposed device is exhaustively investigated using 2-D simulations. The proposed device does not have metallurgical junctions and needs no chemical doping for creating the source and drain regions. Therefore, the proposed device combines the benefits of the bipolar I-MOS (low avalanche breakdown voltage and immunity toward the hot carrier injection) and a junctionless FET (low thermal budget process). The proposed charge plasma n-p-n I-MOS exhibits excellent electrical characteristics, such as a low avalanche breakdown voltage (VB) of 2.123 V, a steep subthreshold swing of 4.53 mV/decade, and an ION/IOFF ratio of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> , as compared with the conventional bipolar I-MOS.
Maxwell Garnett and Bruggeman formalisms for a particulate composite with bianisotropic host medium (1997)

We present here the application of Maxwell Garnett and Bruggeman formalisms to homogenize very general bianisotropic-in-bianisotropic particulate composites, assuming the inclusion particles to be ellipsoidal. © 1997 John Wiley & Sons, Inc. Microwave Opt Technol Lett 15: 263–266, 1997.
Time-Frequency Distribution of Evoked Otoacoustic Emissions (1997)

Otoacoustic emissions (OAE) are non-stationary signals that vary in time depending on the characteristics of the stimulus. Traditional spectral analysis using Fourier methods ignores the effects of time and can miss important temporal information. Therefore, a better form of spectral analysis requires the use of time-frequency distribution methods. Traditionally, short time Fourier transforms (STFT), commonly known as spectrograms, are used to provide such time-frequency representations. STFT however, suffer from poor resolution and do not provide enough detail about the characteristics of the emissions. In this study, recently developed time-frequency distributions, the Wigner Distribution (WD) and the Choi-Williams Distribution (CWD) are investigated to provide high resolution representations of transient evoked OAEs. Although WD has excellent properties for time-frequency analysis, it suffers from cross-term artefacts generated when multiple sinusoids are present. CWD provides a solution to this problem at the expense of poor time and frequency support. In this study, we use both distributions to estimate the cross-products and provide a relatively artefact-free time-frequency distribution of OAEs. This method is applied to both click and tone burst evoked OAE and shows a more detailed time-frequency representation with as many crests and valleys as different latencies.
Non-enzymatic simultaneous detection of l-glutamic acid and uric acid using mesoporous Co3O4 nanosheets (2016)

Co<sub>3</sub>O<sub>4</sub> nanosheets were synthesized by wet chemical technique at low-temperature in alkaline phase.
Errata: Quantitative two-photon flow cytometry—in vitro and in vivo (2008)

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
High Cell Density Fermentation of Recombinant Escherichia coli with Computer‐Controlled Optimal Growth Rate (1991)

In recent years recombinant DNA technology has enabled us to produce various proteins of therapeutic importance with microorganisms. As an appropriate host organism, E. coli plays a dominant role. Yields of E. coli dry cell mass in shaker flask culture range from 1-2 g/L, whereas in fermentors up to 10 g dry cells/L can be achieved. ZIMET and GBF have developed a high cell density fermentation process that produces E. coli (on a glucose/mineral salt medium) up to more than 100 g dry cells/L in a special fed-batch mode. This cultivation strategy prevents oxygen limitation and hence the accumulation of acetate and other metabolic byproducts. The specific growth rate can be adjusted so that product formation reaches its optimum value. An example of the production of alpha1-interferon is presented. The high cell density fermentations were realized in 30- and 450-L Chemap fermentors (ZIMET) and in a three-stage bioreactor scale-up system (72, 300, and 1,500 L) developed in cooperation with GBF and B. Braun Melsungen AG. Multiloop controllers were used to control the process variables.
Structural Integration of PZT Fibers in Deep Drawn Sheet Metal for Material-integrated Sensing and Actuation (2014)

Today, adaptive sheet metal parts are manufactured by surface bonding of sensors and actuators on shaped structural parts. This paper presents a technology for direct structural integration of lead-zirconate-titanate (PZT) fibers in flat sheet metal and subsequent shaping. Microcavities are microformed into the surface of the metal sheet in which piezoceramic fibers are inserted and joined. After that, the composite is shaped by deep drawing into a complex 3D surface. The production technology is discussed in detail with regard to the limits of each process step. Functional shaped prototypes with ten interconnected parallel piezoceramic fibers were fabricated. The function as transducer and sensor for lamb waves is demonstrated and the degradation due to the shaping is compared for different parameters of the deep drawing process. The composite shapes are cups with a double curvature radius of 100 mm and 250 mm respectively. As a result, degradation of the piezoelectric function varies as a consequence of the process parameters. In the best case, a degradation of the transducer function of 33% was shown in the experiments. The cause of the decreased performance after shaping is discussed and explained by debonding mechanisms. Results of numerical simulations show good agreement with the experimental findings of the optimum process parameters.
Influence of TiIV substitution on the properties of a Li1.5Al0.5Ge1.5(PO4)3 nanofiber-based solid electrolyte (2022)

We report the influence of the partial substitution of Ge with Ti on the properties of NASICON Li<sub>1.5</sub>Al<sub>0.5</sub>Ge<sub>1.5</sub>(PO<sub>4</sub>)<sub>3</sub> (LAGP) nanofibers prepared by electrospinning. Replacing a small amount of Ge (up to 20%) with Ti is advantageous for enhancing both the purity and morphology of LAGP fibers, as observed by X-ray diffraction, electron microscopy and nuclear magnetic resonance spectroscopy. When Ti-substituted LAGP (LAGTP) fibers are used as filler to develop composite polymer electrolytes, the ionic conductivity at 20 °C improves by a factor of 1.5 compared to the plain polymer electrolyte. Additionally, above 40 °C the LAGTP fiber-based composite electrolytes were more conductive than the equivalent LAGP fiber-based one. We believe that these findings can make a substantial contribution to optimizing current methods and developing novel synthesis approaches for NASICON based electrolytes.
L’interessamento epatico come indicatore di malattia aggressiva nell’amiloidosi AL: ruolo delle catene leggere libere in 225 pazienti (2010)

Studi precedenti hanno associato la presenza d’interessamento epatico ad una ridotta prognosi in pazienti con amiloidosi AL. Tuttavia, la ragione di questa ridotta sopravvivenza rimane sconosciuta. Abbiamo valutato le differenti presentazioni cliniche e la sopravvivenza di 225 pazienti con e 643 pazienti senza interessamento epa-tico, appartenenti ad una serie di 868 pazienti consecutivi con amiloidosi AL diagnosticati tra il 1986 ed il 2007. I pazienti con interessamento epatico e cloni λ avevano una disfunzione cardiaca più severa mostrata ed una ri-dotta mediana di sopravvivenza (1.4 anni) rispetto ai soggetti con interessamento epatico e cloni κ (4.8 anni) e ai pazienti senza interessamento epatico (4.4 anni). La ridotta sopravvivenza dei pazienti con interessamento epati-co rispetto a chi non ha tale interessamento tra quelli che hanno un clone λ, è stata confermata nei sottogruppi di pazienti con interessamento cardiaco, con scompenso cardiaco e senza interessamento cardiaco. Questi dati indi-cano che la presenza di interessamento epatico nei pazienti con amiloidosi AL è un indicatore di una malattia più aggressiva, probabilmente caratterizzata da una più elevata cardiotossicità delle catene leggere amiloidogeniche.
Optical Frequency Conversion in Silica-Whispering-Gallery-Mode Microspherical Resonators (2014)

High quality factor whispering-gallery-mode microresonators are ideally suited for nonlinear optical interactions. We analyze, experimentally and theoretically, a variety of χ((3)) nonlinear interactions in silica microspheres, consisting of third harmonic generation and Raman assisted third order sum-frequency generation in the visible. A tunable, room temperature, cw multicolor emission in silica microspherical whispering-gallery-mode microresonators has been achieved by controlling the cavity mode dispersion and exciting nonequatorial modes for efficient frequency conversion.
Superballistic transport and anomalous diffusion in inhomogeneous lattices (2012)

We report on how the structure of an inhomogeneous time-independent system allows for anomalous diffusive spreading as well as superballistic transport. We prove our theoretical findings with experiments in optical waveguide arrays.
Load Test and Load Rating of an Innovative Recycled Plastic Lumber (RPL) Bridge (2011)

The Engineer Research and Development Center (ERDC) bridge team evaluated the world’s first thermoplastic composite bridge to determine the appropriate military load classification (MLC) and civilian load rating of the structure. Live-load tests were conducted on bridge T-8518 located on Tuckers Road in Camp Mackall near Fort Bragg, NC. The bridge was designed to be capable of supporting loads exceeding 70 tons and to replace a dilapidated wood timber bridge, which was limited to a maximum load of 4.7 tons. An initial load testing was required to obtain the responses of the bridge to the live loads in order to determine its load capacity ratings to establish if the recycled plastic lumber (RPL) structure could safely carry an M1 tank. Results from the load test were used for the numerical evaluations using a finite-element analysis (FEA) of the entire superstructure. Both field data and FEA results were reasonably accurate. The RPL bridge generally performed in a normal linear-elastic manner, relatively small visco-elastic responses were observed with the heavier M1 tank. This study is used to describe the behavior of RPL bridge under a civilian and military moving load and to provide structural performance information.
A Julia--Carathéodory theorem for hyperbolically monotone mappings in the Hilbert ball (2006)

We establish a Julia--Carathéodory theorem and a boundary Schwarz--Wolff lemma for hyperbolically monotone mappings in the open unit ball of a complex Hilbert space
Luminescent Solar Concentrators Based on Energy Transfer from an Aggregation-Induced Emitter Conjugated Polymer (2019)

Luminescent solar concentrators (LSCs) are solar-harvesting devices fabricated from a transparent waveguide that is doped or coated with lumophores. Despite their potential for architectural integration, the optical efficiency of LSCs is often limited by incomplete harvesting of solar radiation and aggregation-caused quenching (ACQ) of lumophores in the solid state. Here, we demonstrate a multilumophore LSC design that circumvents these challenges through a combination of nonradiative Förster resonance energy transfer (FRET) and aggregation-induced emission (AIE). The LSC incorporates a green-emitting poly(tetraphenylethylene), p-O-TPE, as an energy donor and a red-emitting perylene bisimide molecular dye (PDI-Sil) as the energy acceptor, within an organic-inorganic hybrid diureasil waveguide. Steady-state photoluminescence studies demonstrate the diureasil host induced AIE from the p-O-PTE donor polymer, leading to a high photoluminescence quantum yield (PLQY) of ∼45% and a large Stokes shift of ∼150 nm. Covalent grafting of the PDI-Sil acceptor to the siliceous domains of the diureasil waveguide also inhibits nonradiative losses by preventing molecular aggregation. Due to the excellent spectral overlap, FRET was shown to occur from p-O-TPE to PDI-Sil, which increased with acceptor concentration. As a result, the final LSC (4.5 cm × 4.5 cm × 0.3 cm) with an optimized donor-acceptor ratio (1:1 by wt %) exhibited an internal photon efficiency of 20%, demonstrating a viable design for LSCs utilizing an AIE-based FRET approach to improve the solar-harvesting performance.