gebhart/patrepeval huggingface dataset:
Forgotten driving forces in right heart failure (Part II): experimental study (2012)

The pulsatile suit can be used safely as a noninvasive cardiac-assist device in acute right ventricular failure. This represents a cost-effective nearly physiological method, suitable for adults and children.
Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis (2016)

The current data indicate that FLT3 mutation status did not adversely impact overall survival after HCT, and about 50% of patients with this mutation who underwent HCT were long-term survivors. Cancer 2016;122:3005-3014. © 2016 American Cancer Society.
Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes (2010)

Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L. monocytogenes can infect non-phagocytic cells by two means: direct invasion and cell-to-cell spread. The relative contribution of each method to placental infection is controversial, as is the anatomical site of invasion. Here, we report for the first time the use of first trimester placental organ cultures to quantitatively analyze L. monocytogenes infection of the human placenta. Contrary to previous reports, we found that the syncytiotrophoblast, which constitutes most of the placental surface and is bathed in maternal blood, was highly resistant to L. monocytogenes infection by either internalin-mediated invasion or cell-to-cell spread. Instead, extravillous cytotrophoblasts-which anchor the placenta in the decidua (uterine lining) and abundantly express E-cadherin-served as the primary portal of entry for L. monocytogenes from both extracellular and intracellular compartments. Subsequent bacterial dissemination to the villous stroma, where fetal capillaries are found, was hampered by further cellular and histological barriers. Our study suggests the placenta has evolved multiple mechanisms to resist pathogen infection, especially from maternal blood. These findings provide a novel explanation why almost all placental pathogens have intracellular life cycles: they may need maternal cells to reach the decidua and infect the placenta.
Automated Solid‐Phase Microextraction GC‐MS/MS Method for Quantification of Volatile Limonene Oxidation Products in Encapsulated Orange Oil (2018)

Abstract Limonene, widely present in consumer products, is prone to oxidation and leads to the formation of undesirable reaction products. A solid‐phase microextraction ( SPME ) GC ‐ MS / MS method was developed for the quantification of volatile limonene oxidation products, in encapsulated oil samples, by the optimization of MS parameters and SPME sampling conditions including fibre coating, temperature and time. The detection limit of the method reached 10 to 15 ppb for the limonene oxides, and less than 5 ppb for carvone and carveol isomers. Standard addition calibration was utilized to compensate for matrix effects of the encapsulation, flavouring, and to optimize the accuracy and versatility of this method. Sample throughput and precision of the method were improved through in‐line automated SPME sample preparation. The popularity of limonene as a flavouring compound in many consumer products, allows this method to be adapted to quantify different levels of volatile limonene oxidation products in encapsulated matrices.
FACTORS INFLUENCING SUCCESS OF INITIAL RESUSCITATION IN PENETRATING CARDIAC WOUNDS (1992)

Buckman, Robert F. Jr. MD; Badellino, Michael M. MD; Asensio, Juan A. MD; Grosh, Juliecca MD; Gass, Jennifer MD Author Information
End point detection in ion milling processes by sputter-induced optical emission spectroscopy (1984)

The characteristic optical emission from the sputtered material during ion milling processes can provide an unambiguous indication of the presence of the specific etched species. By monitoring the intensity of a representative emission line, the etching process can be precisely terminated at an interface. Enhancement of the etching end point is possible by using a dual-channel photodetection system operating in a ratio or difference mode. The installation of the optical detection system to an existing etching chamber has been greatly facilitated by the use of optical fibers. Using a commercial ion milling system, experimental data for a number of etching processes have been obtained. The result demonstrates that sputter-induced optical emission spectroscopy offers many advantages over other techniques in detecting the etching end point of ion milling processes.
Cost‐effective post‐exposure prevention of poison ivy dermatitis (2000)

Our study showed 70%, 61.8%, and 56. 4% protection with Tecnu, Goop, and Dial, respectively, when compared to the positive control, or to the possible maximum response, with a cost per ounce (in a local drug and automotive store) of $1.25, $0.07, and $0.07, respectively, for a decrease in protection that is nonsignificant.
Effect of Coordination Biofeedback on (Re)Learning Preferred Postural Patterns in Post-stroke Patients (2011)

After stroke, ankle-hip coordination during stance is characterized by changes in the postural system dynamics, specifically the disappearance of the in-phase pattern and the reduced stability of the anti-phase pattern. This study was conducted to assess the success of a coordination visual biofeedback for the (re)learning of the two preferred patterns, and to explore the effect of this treatment on postural and functional abilities. Twenty four patients were randomly assigned to one of two experimental groups or to a control group. During one month, patients from experimental groups followed a training protocol on the two preferred postural patterns using the biofeedback device. These two groups improved their in-phase coordination after the (re)learning compared with control group, and showed a related improvement of the functional independence measure. Results suggest that (re)learning the in-phase pattern is possible and seems to improve independence in poststroke patients.
Phase decorrelation-OCT for monitoring the depth-dependent effect of accelerated corneal crosslinking (2022)

While previously published work demonstrated the overall sensitivity of phase decorrelation optical coherence tomography (PhD-OCT) to crosslinking (CXL) in the cornea, it did not capitalize on the depth-resolving capability of PhD-OCT. Here, PhD-OCT was used to observe the depth-dependent differences in accelerated crosslinking efficiency with and without supplemental oxygen. Traditional crosslinking showed good crosslink formation in the anterior stroma. For accelerated CXL with supplemental oxygen, a significant stiffening effect was seen throughout the stroma. No stiffening was observed in accelerated CXL without supplemental oxygen or sham treatment. Thus, PhD-OCT may observe depth-dependent, protocol-specific changes in corneal tissue due to crosslinking.
OUTPATIENT REGISTRY OF CARDIOVASCULAR DISEASES (RECVASA): PROSPECTIVE FOLLOW-UP DATA, ESTIMATION OF RISKS AND OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION (2014)

Aim. To evaluate outcomes and risk of their occurrence in patients with atrial fibrillation (AF) within 12 months of follow-up in actual outpatient practice. Material and methods. A total of 3690 patients with AF, arterial hypertension (HT), ischemic heart disease (IHD) and chronic heart failure (CHF) consulted by general practitioners and cardiologists of three outpatient clinics of Ryazan, were enrolled into the outpatient REgistry of CardioVAScular diseAses (RECVASA). 530 of 3690 (14.4%) patients had the diagnosis of "atrial fibrillation" in their outpatient charts. Estimation of the end points within 12 months after inclusion into the registry was performed based on the data received from the contacts with patients or a documented fact of death. Results. 39 (7.4%) patients had died during this period [30 (76.9%) of them due to cardiovascular causes], 18 (3.4%) – had undergone stroke, 3 (0.6%) – myocardial infarction, 2 (0.4%) patients had cardiovascular surgery. There were 63 hospitalizations due to cardiovascular diseases (CVD). AF did not lead to significant increase in cardiovascular death risk [odds ratio (OR)=1.31, p=0.21] and stroke risk (OR=1.64, р=0.09) within 12 months after inclusion into the registry, but the risk of hospitalization due to CVD was significantly higher(OR=2.88, р=0.0001). Permanent AF significantly increased the risk of stroke (OR=2.07, р=0.04). Such factors as diabetes, prior stroke, systolic blood pressure (SBP)&lt;110 mm Hg and heart rate (HR)≥90 bpm significantly increased all-cause death risk (OR=2.49, р=0.008; OR=2.46, р=0.01; OR=7.6, р=0.003; OR=15.3, р=0.01, respectively). Patients treated with ACE inhibitors or angiotensin receptor blockers (ARB) had lower all-cause and cardiovascular death risks: OR=0.38, р=0.01 and OR=0.25, р=0.02, respectively. Other drugs revealed no significant influence on prognosis. Conclusion. According to the outpatient registry RECVASA data such factors as permanent type of AF, diabetes mellitus, prior stroke, SBP&lt;110 mm Hg and HR≥90 bpm, ACE inhibitors/ARB prescription significantly influenced prognosis in patients with AF. Estimating outcomes in AF patients, combination with HT, IHD, CHF and non-cardiac comorbidities must be taken into account as well as peculiarities of these diseases drug treatment.
Production of single phase chalcopyrite CuInSe2 by spray pyrolysis (1984)

Thin films (0.5–2 μ) of CuInSe2 were prepared by spray pyrolysis from solutions with various pH levels and initial Cu:In ratios, and in which the Cu source was either CuCl or CuCl2. The substrate temperature was varied between 225 and 300 °C. All films prepared with CuCl2 were chalcopyrite, while only Cu-rich CuCl based films exhibited this phase. The appearance of Cu2−xSe and/or Cu2/Se as a second phase was found to depend strongly on solution stoichiometry, pH, temperature, and substrate. Two layer structures consisting of a Cu-deficient layer on top of a Cu-rich layer were produced without the presence of any second phases on both glass and Mo-coated glass. This is the first time single phase chalcopyrite Cu-deficient layers have been fabricated by spray pyrolysis. A CuInSe2/CdS photovoltaic cell made from a single phase double layer filme on glass gave a Voc of 0.558 V after heat treatment. This Voc is higher than any reported to date. Absorption spectra have also been measured, and are found to improve when CuCl2 is used instead of CuCl.
Untersuchung zur Fettpräferenz nach Roux-en-Y Gastric Bypass in der Ratte Analysis of fat preference after Roux-en-Y Gastric Bypass in rats (2010)

Background. Patients after Roux-en-Y gastric bypass (RYGB) report a lack of desire to consume fatty food [1–4]. We performed three experiments to investigate this phenomenon. Methods. Rats (n = 26) were randomised to gastric bypass or sham-operations and were offered low fat chow or high fat chow before and after surgery for 48 hours. Before and 20 days or 200 days after gastric bypass or shamoperation surgery (each n = 10) rats were tested in a 2-bottle preference experiment with increasing concentrations of Intralipid (0.005 %, 0.01 %, 0.05 %, 0.1 %, 0.5 %, 1 %, 5 %). Water and Intralipid intake were measured daily. Rats after gastric bypass (n = 16) and sham-operation (n = 22) were subjected to conditioned taste aversion testing using an oral gavage with corn oil or saline. A 0.3 % saccharine solution was used as conditioned stimulus. Results. Gastric bypass rats significantly reduced their preference for the high fat diet (28.2 ± 1 g vs. 16.6 ± 1 g, p < 0.05), while they significantly increased their intake of the normal chow (3 ± 0.5 g vs. 8.4 ± 1 g, p < 0.05). Sham-operated animals showed no changes of preference. Gastric bypass rats showed a reduced preference for the higher Intralipid solutions compared to sham-operated rats (Intralipid 0.5 %: 82.4 ± 3.8 % vs. 66.5 ± 5.5 %, p < 0.01; Intralipid 1 %: 90.7 ± 2.8 % vs. 74.1 ± 4.5 %, p < 0.01; Intralipid 5 %: 92.8 ± 1.7 % vs. 63.2 ± 5.5 %, p < 0.001). Observations were similar 200 days after surgery. Saccharine intake expressed as percentage of total fluid intake was significantly reduced in gastric bypass rats after corn oil gavage in comparison to all other groups (sham saline: 93.1 ± 3.6 % vs. sham corn oil: 87.8 ± 6.1 % vs. bypass saline: 90.1 ± 4.0 % vs. bypass corn oil: 43.6 ± 14.5 %, p < 0.001). Conclusions. Gastric bypass in rats reduced preference for high fat chow and high concentrations of fat solutions. Our observations correlate with clinical reports of patients. Conditioned taste aversion may contribute to this phenomenon.
High-speed handheld multiphoton multifoci microscopy (2004)

For the last decade, multiphoton excitation fluorescence microscopy has found numerous applications in biology. Multiphoton microscopy provides several advantages over conventional fluorescence microscopy, including increased penetration depth, improved signal-to-background ratio, and reduced photodamage. Despite its suitability for tissue imaging, multiphoton microscopy has not been used for in-vivo clinical applications due to its lack of portability and its slow imaging speed. Multiphoton microscopy has recently been improved with the development of high speed imaging systems and handheld devices. High speed imaging has been achieved by simultaneously exciting multiple foci in the specimen, known as multiphoton multifocal microscopy (MMM). Compact devices have been developed by combining fiber optic delivery and miniaturized scanning devices. We have developed a handheld device for high speed multiphoton microscopy based on optical fiber delivery, multifoci excitation/detection and a novel scanner. Our system is designed to be sufficiently compact such that it can be used for in vivo clinical imaging, or optical biopsy with potential applications in dermal, cervical and colorectal cancer diagnosis. The power available from a typical Ti:sapphire laser is fully utilized by using multifoci excitation; this results in reduced image acquisition time. Femto-second pulses from a Ti:sapphire laser are delivered to our system through conventional optical fiber. We realize multifoci excitation with a microlens array, and multifoci detection with a multi-anode PMT. A high bandwidth tip tilt mirror is further used as the scanning element for high speed imaging. The feasibility of this handheld MMM is demonstrated by measuring the performance of major components individually. This work is supported by NIH R33 CA091354.
Determination of Carbon Black Particle Size by Reflectance (1967)

Abstract A simple technique of sample preparation using dry carbon black samples has been developed which gives a carbon black surface of reasonably reproducible reflectance, using a commercially available and reasonably priced reflectance meter. The reflectance values were calibrated against particle size determined by Kraus and Rollmann using the calorimetric procedure of Harkins and Jura.
412th Brookhaven Lecture (2006)

With new radiation detectors, finding smuggled nuclear materials in a huge container among thousands of others in a busy port becomes possible. To learn about these new detectors from a specialist who has spent several years developing these technologies, watch the 412th Brookhaven Lecture, Advanced Neutron Detection Methods: New Tools for Countering Nuclear Terrorism.
ChemInform Abstract: Di‐ and Trinuclear Metal Complexes of Diboraheterocycles. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery (2018)

Clinicaltrials.gov identifier: NCT02690233.
Seasonal Difference in Antioxidant Capacity and Active Compounds Contents of Eucommia ulmoides Oliver Leaf (2013)

Leaf of Eucommia ulmoides Oliver (EU) is a Traditional Chinese Medicine and a functional food in China. Antioxidant contents of EU leaves, which were collected monthly during the period of May-October in three years, were determined. Samples' antioxidant capacity was characterized by DPPH radical scavenging activity, hydroxyl radical scavenging activity, ferrous chelating ability, and antioxidant capacity in linoleic acid emulsion and in rapeseed oil assays. The results showed that contents of some active compounds and antioxidant activity were related to a certain time of the year. Samples collected in August showed high content of phenolics, and the samples collected in May contained higher amount of flavonoids than other samples. Leaves collected in May or June exhibited high contents of rutin, quercetin, geniposidic acid and aucubin. The August leaves showed stable and high DPPH radical scavenging activity, and ferrous chelating ability. May samples showed strong inhibitory effects on oxidation of rapeseed oil and linoleic acid. The DPPH radical scavenging activity was related to the total phenolics content. Flavonoids played an important role in the inhibitory effects on rapeseed oil and linoleic acid oxidation. Therefore, August and May were indicated as the best months to harvest EU leaves for industry.
Pressure Gain Combustion Application to Marine and Industrial Gas Turbines (2012)

Renewed interest in pressure gain combustion applied as a replacement of conventional combustors within gas turbine engines creates the potential for greatly increased capability engines in the marine power market segment. A limited analysis has been conducted to estimate the degree of improvements possible in engine thermal efficiency and specific work for a type of wave rotor device utilizing these principles. The analysis considers a realistic level of component losses. The features of this innovative technology are compared with those of more common incremental improvement types of technology for the purpose of assessing potentials for initial market entry within the marine gas turbine market. Both recuperation and non-recuperation cycles are analyzed. Specific fuel consumption improvements in excess of 35% over those of a Brayton cycle are indicated. The technology exhibits the greatest percentage potential in improving efficiency for engines utilizing relatively low or moderate mechanical compression pressure ratios. Specific work increases are indicated to be of an equally dramatic magnitude. The advantages of the pressure gain combustion approach are reviewed as well as its technology development status.
Zero voltage mass spectrometry probes and systems (2023)

The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
Autoimmune Hemolytic Anemia in a Dog (1971)

The stability and compatibility of 5-fluorouracil (5-FU) in undiluted or diluted admixtures stored in beta-radiation sterilized portable poly(vinyl chloride) (PVC) infusion bags were investigated. Admixtures containing 5-FU 50 mg ml(-1) not diluted or 25 mg ml(-1) diluted in 0.9% sodium chloride injection were placed in 100 or 250 ml empty PVC reservoirs sterilized initially by beta-irradiation. They were protected from light and placed at 37 degrees C. Two ml quantities were withdrawn immediately after preparation and after storage for 1, 2, 3, 4, 5, 6, 7 and 14 days. For each condition, samples from each admixture were tested for drug concentration by stability-indicating high-performance liquid chromatography. The admixtures were also monitored for precipitation, color change and pH. Evaporative water loss from the containers was also measured. 5-FU was compatible with PVC containers in all tested conditions for 14 days. No loss of drug and no color change were detected throughout the storage period. pH values were stable and neither precipitation nor loss of water through the reservoirs was observed when drug 50 or 25 mg ml(-1) (diluted using 0.9% sodium chloride) was stored in 100 ml capacity polyvinyl PVC bags. However, when stored in 250 ml capacity PVC bags, the 5-FU solution showed precipitation after 13 and 14 days of storage, but no drug loss was detected due to a substantial loss of water. The precipitation of the drug was due to the decrease of pH induced by the dehydrochlorination of PVC during beta-irradiation leading to the formation of hydrochloric acid in solution. Differences observed between 100 and 250 ml capacity bags can be explained by the greater area of PVC present in 250 ml reservoirs, and consequently more HCl formed. Finally, more plasticizer, di-(2-ethylhexyl) phthalate (DEHP), was then detected in drug solutions stored in 250 ml PVC bags. So, we recommend the use of 100 ml bags to store 5-FU at longer storage times and higher temperatures.
Statistical Comparison of Two ROC-curve Estimates Obtained from Partially-paired Datasets (1998)

The authors propose a new generalized method for ROC-curve fitting and statistical testing that allows researchers to utilize all of the data collected in an experimental comparison of two diagnostic modalities, even if some patients have not been studied with both modalities. Their new algorithm, ROCKIT, subsumes previous algorithms as special cases. It conducts all analyses available from previous ROC software and provides 95% confidence intervals for all estimates. ROCKIT was tested on more than half a million computer-simulated datasets of various sizes and configurations representing a range of population ROC curves. The algorithm successfully converged for more than 99.8% of all datasets studied. The type I error rates of the new algorithm's statistical test for differences in Az estimates were excellent for datasets typically encountered in practice, but diverged from alpha for datasets arising from some extreme situations.
The receptor tyrosine kinase Axl in cancer: Biological functions and therapeutic implications (2013)

The receptor tyrosine kinase Axl has been implicated in the malignancy of different types of cancer. Emerging evidence of Axl upregulation in numerous cancers, as well as reports demonstrating that its inhibition blocks tumor formation in animal models, highlight the importance of Axl as a new potential therapeutic target. Furthermore, recent data demonstrate that Axl plays a pivotal role in resistance to chemotherapeutic regimens. In this review we discuss the functions of Axl and its regulation and role in cancer development, resistance to therapy, and its importance as a potential drug target, focusing on acute myeloid leukemia, breast, prostate and non-small cell lung cancers.