gebhart/patrepeval huggingface dataset:
Abstract 2834: Antitumor effect of AGM 130 (5’-OH-5-nitro-Indirubin oxime), a cyclin-dependent kinase inhibitor in colorectal cancer cells (2016)

Abstract The AGM 130 (5’-OH-5-nitro-Indirubin oxime) compound is derived from Indirubin, which is an ingredient of Danggui Longhui Wan and used in traditional Chinese medicine. AGM 130 can inhibit the proliferation of a variety cells by arresting the cell in the G2/M phase of the cell cycle, it is a cyclin-dependent kinase (CDK) inhibitor that has anti-proliferative activity and apoptotic effects on cancer cells. AGM 130 has improved water solubility compared to Indirubin, however still displays a low solubility in biologic fluids and a poor bioavailability. This poor water solubility limits the clinical application of AGM 130 to treat cancer. In this study, we decided to develop and evaluate a SNEDDS (self-nanoemulsifying drug delivery systems) formulation containing AGM130 for improving its solubility, dissolution rate, and bioavailability. To check the anti-proliferative effect of the AGM 130 compound on colon cancer cell line, we performed the MTT assay with the CT-26 cancer cell. We also performed cell cycle analysis, apoptotic assays and western blotting. The CT-26 cell bearing mice were treated intraperitoneally with AGM 130 loaded PPG-cRGD, 5-fluorouracil (5-FU) or AGM 130 loaded PPG-cRGD combined with 5-FU. We measured tumor volume and tumor progression of each groups. In vitro, AGM 130 showed significant anti-proliferative activity in CT-26 cell (IC 50, 1.9 μM). Cells treated with AGM 130 showed G2/M cell cycle arrest and also induced apoptosis compared to untreated cells. The western blotting analysis showed that AGM 130 inhibited CKD1/cyclin B1 and also CKD2/cyclin E. The greatest tumor regression (percentage tumor growth inhibition) was observed in the group treated with AGM 130 loaded PPG-cRGD combined with 5-FU. When 5-FU was administrated alone, the anti-tumor effect was inferior to the group treated with AGM 130 loaded PPG-cRGD alone. These results suggest that intraperitoneal administration of AGM 130 loaded PPG-cRGD inhibits tumor progression in a mouse colon cancer. Thus, AGM 130, a cyclin-dependent kinase inhibitors may provide a new therapeutic approach in the treatment of colon cancer. Citation Format: Hyun-Jeong Shim, Jun-Eul Hwang, Woo-Kyun Bae, Myung-Sook Park, Hyo-Jeong Yun, Ji-Hee Lee, Sang-Hee Cho, Ik-Joo Chung. Antitumor effect of AGM 130 (5’-OH-5-nitro-Indirubin oxime), a cyclin-dependent kinase inhibitor in colorectal cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2834.
On the solution of the discrete-time Lyapunov matrix equation in controllable canonical form (1979)

The solution to the discrete-time Lyapunov matrix equation in controllable canonical form is shown to be the inverse of the Schur-Cohn matrix. A simple constructive procedure of Berkhout, based on the backwards Levinson algorithm is discussed and an application of the result in stochastic control is mentioned.
Effects of Surface Reflection on Bearing Tracker Performance (1981)

Recent at-sea testing of a passive sonar bearing tracker indicated that received signal propagation paths which include a surface reflection can result in a substantial increase in bearing error variance. Measurements at high signal-to-noise ratio showed excessive bearing error variance compared to both theory and other measurements when measured Depression/Elevation angle indicated a surface reflected path. It is hypothesized that wavefront scattering due to surface waves is the mechanism for this increase. Based on a Pierson-Moskowitz surface wave spectrum, a simplified acoustic propagation model, the actual test geometry and the parameters of the broadband tracker, effects of surface reflection on tracker performance were analyzed. Resulting work yielded a simple equation which relates random error to surface reflection dependent on (1) test geometry, (2) wind velocity and direction, (3) spatial correlation coefficients between specular points, and (4) the phase center separation between half-beams. Results of calculations show good agreement with the experimental data.
Effects of concentration and temperature of EMIMBF4/acetonitrile electrolyte on the supercapacitive behavior of graphene nanosheets (2012)

Graphene nanosheets (GNSs)–ionic liquids (ILs) electrochemical system is of great interest as it shows excellent electrochemical properties for high performance supercapacitors. In this paper, the effects of concentration and temperature of ILs electrolyte on the electrochemical properties of a GNSs electrode are characterized by cyclic voltammetry (CV), galvanostatic charge/discharge and electrochemical impedance spectroscopy measurements (EIS) in 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF4)/acetonitrile electrolyte. The results show that the internal resistance and the specific capacitance are strongly dependent on the variation of molar concentration of EMIMBF4, and the GNSs electrode exhibits high specific capacitance (128.2 F g−1) and a wide potential window (2.3 V) in 2.0 M EMIMBF4/acetonitrile electrolyte, indicating the excellent electrochemical performance. Moreover, the GNSs electrode has wide operating temperatures ranging from −20 °C to 60 °C with a potential window from −0.6 V to 1.5 V in the EMIMBF4/acetonitrile electrolyte. The result also reveals a weak dependence of the supercapacitive performance of the GNSs electrode on the temperature of the EMIMBF4/acetonitrile electrolyte. In addition, the specific capacitances have almost no decay after 1500 charge/discharge cycles in the above mentioned temperature region, demonstrating the good stability of the GNSs–ILs system in high-temperature and low-temperature environments.
Amphiphilic Janus Micelles with Polystyrene and Poly(methacrylic acid) Hemispheres (2003)

We describe the synthesis and the solution properties of Janus micelles containing a polybutadiene (PB) core and a compartmentalized corona consisting of a poly(methacrylic acid) (PMAA) and a polystyrene (PS) hemisphere. The Janus micelles were obtained via cross-linking the middle block of a microphase-separated PS-block-PB-block-PMMA triblock copolymer in the bulk state, followed by alkaline hydrolysis of the poly(methyl methacrylate) (PMMA) ester groups. Results of fluorescence correlation spectroscopy, field flow fractionation, light scattering, cryogenic transmission electron microscopy, scanning electron microscopy, and scanning force microscopy indicate that above a critical aggregation concentration of about 0.03 g/L spherical supermicelles are formed from about 30 PS-PMAA micelles in aqueous solution in the presence of NaCl. These supermicelles have radii of 40-60 nm, significantly increasing on ionization (pH >6). In addition, very large spherical objects are observed with radii of 100-250 nm.
Parameter and structural identifiability concepts and ambiguities: a critical review and analysis (1980)

The notion of identifiability addresses the question of whether it is at all possible to obtain unique solutions for unknown parameters of interest in a mathematical model, from data collected in well-defined stimulus-response experiments performed on a dynamic system represented by the model. This critical aspect of the modeling and data reduction problem is reviewed, analyzed, and unified, with emphasis on applications in biology. Several physiological system models are examined in detail. They illustrate the importance of identifiability analysis prior to performing a parameter estimation experiment, the algebraic difficulties, possible pitfalls, and not-so-apparent ambiguities that may be encountered--even for simple models--and the utility of the concept in experiment design. Methods for testing for identifiability also are reviewed and compared, with emphasis on applicability and limitations. The usefulness of a given model for predicting the time course of system variables (not parameters) of interest normally inaccessible to direct measurement (e.g., tissue concentrations), a common use for quantitative models, is shown to depend intimately on the identifiability properties of the model, in a manner not easy but essential to assess: state variable predictions made in this manner can be inherently ambiguous.
A 3–10 GHz contact-less complex dielectric spectroscopy system (2017)

In this paper, a contact-less broadband dielectric spectroscopy (BDS) system with a combined frequency domain (FD)/ time domain (TD) technique for 3-10 GHz frequency range is presented. The material-under-test (MUT) is placed in the middle of two radiative near-field-coupled ultra wide band (UWB) Vivaldi antennas which act as the sensing elements. To enhance the detection accuracy, a new baseband signal is generated by combining multiple up converted Gaussian signals. A calibration method, which is based on subtracting the output of system from a reference material (air), is also utilized, in order to solely detect the magnitude and phase variations caused by the MUT, and eliminate the effects of the transmitter, the sensing unit, and the receiver. The proposed system is tested for xylene, ethanol, and methanol, and the measurement results are verified comparing with the direct measurements of vector network analyzer (VNA).
An adaptive algorithm for antenna array low-rank processing in cellular TDMA base stations (1998)

A new adaptive algorithm for blind interference rejection and multipath mitigation is studied and applied to antenna array processing in the reverse channel of a time-division multiple-access (TDMA) cellular communication system. The method is based on higher order statistics (HOS) processing of the baseband vector samples at the antenna array output. The similarity between the cumulant-based solution and the standard multivariable least-squares solution is exploited to derive an efficient adaptive algorithm based on a low-rank processing architecture. The algorithm exhibits good tracking and enhanced identification capability with respect to traditional least-squares methods.
Factors Affecting the Extraction of Intact Ribonucleic Acid from Plant Tissues Containing Interfering Phenolic Compounds (1977)

Using conventional methods it is impossible to extract RNA as uncomplexed intact molecules from the leaves of grapevines (Vitis vinifera L.) and from a number of woody perennial species that contain high levels of reactive phenolic compounds. A procedure involving the use of high concentrations of the chaotropic agent sodium perchlorate prevents the binding of phenolic compounds to RNA during extraction. Analyses of the phenolics present in plant tissues used in these experiments indicate that there is a poor correlation between the total phenolic content and the complexing of RNA. However, qualitative analyses suggest that proanthocyanidins are involved in the tanning of RNA during conventional extractions.
Jumping particle model. A study of the phase space of a non-linear dynamical system below its transition to chaos (1985)

Bifurcation cascades in a non-linear dynamical system are directly observed. Experimental results are compared with predictions of the Zaslavskij-Rachko mapping. Experimental evidence for coexistence of a number of individual modes is provided.
Trifluoromethyl-substituted benziminazoles (1954)

R. Belcher, A. Sykes and J. C. Tatlow, J. Chem. Soc., 1954, 4159 DOI: 10.1039/JR9540004159
CLINICAL CORRELATES OF CIGARETTE SMOKING AND NICOTINE DEPENDENCE IN ALCOHOL-DEPENDENT MEN AND WOMEN (2000)

This paper examines the clinical characteristics associated with tobacco use and nicotine dependence in a large sample of alcohol-dependent subjects. The goal was to determine if the characteristics of the alcohol use history were associated with the smoking status, even after controlling for additional characteristics, such as the antisocial personality disorder, other drug dependence and gender. As part of the Collaborative Study on the Genetics of Alcoholism, a semi-structured interview, including a detailed history of alcohol and tobacco use, was administered to 1005 alcohol-dependent men and women, made up of 658 (65.5%) current smokers, 167 (16.6%) former smokers, and 180 (17.9%) non-smokers. Among former smokers, 50.3%, and among current smokers, 72.8% had ever been nicotine-dependent (DSM-III-R). Current smokers and nicotine-dependent subjects had a greater severity of alcohol dependence, even as evaluated through logistic regression analyses in which gender and associated diagnoses were considered. The data also enabled us to study the relationships among depression, nicotine dependence, and alcohol dependence, with most of the correlation occurring for substance-induced, not independent, mood disorders.
Signal energy distribution in time and frequency (1968)

The Fourier representation of signals and its relation to the signal structure in time and frequency, and more generally the inherent properties of phase-modulated signals, have received considerable attention in the past. These topics have led to such seemingly unrelated studies as the representation of a signal in a combined time-frequency plane, "instantaneous power spectra," and the ambiguity function and its transform relations. It is shown in this paper that the studies can be unified by the introduction of the concept of the complex energy density function of a signal. The function is an extension and combination of the one-dimensional energy density functions in time and frequency, the energy density spectrum <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">|\Psi(f)|^{2}</tex> , and energy density waveform <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">|\psi (t)|^{2}</tex> . On the basis of the complex energy density function, the significance of complicated-appearing transform relations is readily understood. The new concept also conveys a good insight into the internal structure of phase-modulated signals.
An Enhanced Spatial and Temporal Data Fusion Model for Fusing Landsat and MODIS Surface Reflectance to Generate High Temporal Landsat-Like Data (2013)

Remotely sensed data, with high spatial and temporal resolutions, can hardly be provided by only one sensor due to the tradeoff in sensor designs that balance spatial resolutions and temporal coverage. However, they are urgently needed for improving the ability of monitoring rapid landscape changes at fine scales (e.g., 30 m). One approach to acquire them is by fusing observations from sensors with different characteristics (e.g., Enhanced Thematic Mapper Plus (ETM+) and Moderate Resolution Imaging Spectroradiometer (MODIS)). The existing data fusion algorithms, such as the Spatial and Temporal Data Fusion Model (STDFM), have achieved some significant progress in this field. This paper puts forward an Enhanced Spatial and Temporal Data Fusion Model (ESTDFM) based on the STDFM algorithm, by introducing a patch-based ISODATA classification method, the sliding window technology, and the temporal-weight concept. Time-series ETM+ and MODIS surface reflectance are used as test data for comparing the two algorithms. Results show that the prediction ability of the ESTDFM algorithm has been significantly improved, and is even more satisfactory in the near-infrared band (the contrasting average absolute difference [AAD]: 0.0167 vs. 0.0265). The enhanced algorithm will support subsequent research on monitoring land surface dynamic changes at finer scales.
The anatomical suitability of the C1–2 complex for transarticular screw fixation (1996)

Posterior transarticular screw fixation of the C1-2 complex has become an accepted method of rigid internal fixation for patients requiring posterior C1-2 fusion. The principal limitation of this procedure is the location of the vertebral artery, because an anomalous position may prohibit screw placement. In this study, a consecutive series of computerized tomography (CT) scans was reviewed, and the suitability of each patient for transarticular screw fixation was evaluated. All of the fine-slice axial C1-2 CT scans and reconstructions performed on a spiral scanner over 2 years were reviewed. A novel screw trajectory reconstruction was designed to visualize the potential path of a transarticular screw in the plane of the reconstruction. Scans were reviewed for bone anatomy and the position of the transverse foramen. Seventeen (18%) of 94 patients had a high-riding transverse foramen on at least one side of the C-2 vertebra that would prohibit the placement of transarticular screws. The left side was involved in nine patients and the right in five. Three patients had bilateral anomalies. The mean age of the group with anomalies (35.9 years, range 10-76) was not significantly different from the overall mean age (35.7 years, range 6-94). An additional five patients (5%) were considered to have anatomy in which screw placement was feasible but risky. On the basis of these data, it is postulated that 18% to 23% of patients may not be suitable candidates for posterior C1-2 transarticular screw fixation on at least one side.
TSAP6 Facilitates the Secretion of Translationally Controlled Tumor Protein/Histamine-releasing Factor via a Nonclassical Pathway (2004)

Translationally controlled tumor protein (TCTP) is cytoplasmic and structurally related to guanine-nucleotide free chaperones. TCTP (also called histamine-releasing factor) has been described previously as a secreted protein that participates in inflammatory responses by promoting the release of histamine. How TCTP is eventually exported out of the cell to promote such activities is unknown. Here we show that TCTP secretion was insensitive to either brefeldin A or monensin, suggesting that it proceeds via an endoplasmic reticulum/Golgi-independent or nonclassical pathway. Moreover, our analyses also suggest that secreted TCTP originates from pre-existing pools. TSAP6, a p53-inducible 5-6 transmembrane protein, was found to interact with TCTP in a yeast two-hybrid hunt. GST pull down assays confirmed their direct interaction, and immunofluorescence analysis revealed their partial co-distribution to vesicular-like structures at the plasma membrane and around the nucleus. Functionally, the overexpression of TSAP6 consistently leads to enhanced secretion of both endogenously and exogenously expressed TCTP. Finally, we found TCTP in preparations of small secreted vesicles called exosomes, which have been suggested as a possible pathway for nonclassical secretion. Overexpression of TSAP6 also increased TCTP levels in exosome preparations. Altogether, these data identify a novel role for TSAP6 in the export of TCTP and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion.
The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells (2007)

Studies on the thymic ontogeny of naturally arising CD4(+)CD25(+) regulatory T cells (TR cells) are complicated by the contamination of recirculating cells from the periphery (both activated CD4(+) T and TR cells). We investigated TR cells in anti-CD4 antibody transgenic (Tg) (GK) mice that continuously deplete peripheral CD4 T cells but not thymocytes so that the generation of thymic TR cells and their developmental requirement can be accurately assessed. We show that in the thymuses of mice that lack peripheral CD4(+) cells, TR cells were present but were fewer in number compared with wild-type (WT) mice. Therefore, we show that peripheral TR cells do re-enter the thymus, comprising 20% of TR cells in the normal thymus. TR cells from both WT and GK mice expressed Foxp3 and GITR, and suppressed the proliferation of CD25(-)CD4(+) T cells. Furthermore, the co-stimulation requirements for TR generation were evaluated in mice with or without peripheral CD4 cells. Splenic TR cells in CD40L(-/-) mice and CTLA4Ig Tg mice were fewer compared with WT mice. Mice deficient in both co-stimulatory pathways had further reduction in splenic TR cells. Unlike the periphery, the reduction in thymic TR cells was only seen for CD40L(-/-) but not for CTLA4Ig Tg mice. Therefore, we found that the co-stimulation requirements for the thymic development of TR cells differed from those for peripheral homeostasis.
Microsurgical Training with Porcine Thigh Infusion Model (2013)

We herein present our experience with microsurgical training using a porcine thigh infusion model, which resembles living animal models. The main femoral artery was cannulated with a 24G angioneedle and fixed with 4-0 black silk sutures. Microanastomoses were performed on the femoral vessels of porcine thighs using end-to-end and end-to-side techniques. During the microanastomoses, dyed 0.9% isotonic sodium chloride was infused at 200 to 850 mL/min using an infusion pump. No anastomosis site leakage was observed and the patency of the anastomosis site was maintained. We consider the porcine thigh infusion model to be appropriate for the beginner trainee because the large vessel size enables him or her to practice. In addition, our model provides a circulation environment similar to the in vivo human environment. We believe that our model is more convenient than living animal models and more accurate than models that do not provide a circulation environment.
Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1 (2005)

Platelet-derived growth factor D-chain (PDGF-D) is the newest member of the PDGF family of mitogens and chemoattractants expressed in a wide variety of cell types, including vascular smooth muscle cells (SMCs). The molecular mechanisms regulating PDGF-D transcription are not known. Primer extension analysis mapped a single transcriptional start site to the ccAGCGC motif with several potential Ets motifs located upstream. Ets-1, but not Ets-1 bearing only the DNA-binding domain, activates the PDGF-D promoter and mRNA expression in SMCs. Ets site D3 ((-470)GGAT(-467)) is singly required for basal and Ets-1-inducible PDGF-D promoter-dependent expression. D3 supports the interaction of endogenous and recombinant Ets-1 and Sp1. Sp1, like Ets-1, induces PDGF-D transcription and mRNA expression, which is blocked by mutant Ets-1. H2O2 stimulates Ets-1, but not Sp1, and activates D3-dependent PDGF-D transcription. Ets-1 and Sp1 siRNA block peroxide-inducible PDGF-D expression. Angiotensin II (ATII) induction of PDGF-D and Ets-1 was blocked by prior incubation of the cells with PEG-catalase, but not BSA, indicating that ATII-inducible Ets-1 and PDGF-D expression is mediated via H2O2. Thus, 2 separate trans-acting factors regulate PDGF-D transcription, alone and in response to oxidative stress.
A negative D-dimer identifies patients at low risk of death within 30 days: a prospective observational emergency department cohort study (2019)

Normal D-dimer levels identified patients at low risk of 30-day mortality. Since most patients who died within 30 days presented with normal or near normal vital signs, D-dimer levels appear to provide additional prognostic information.
WHAD: Wikipedia historical attributes data (2013)

This paper describes the generation of temporally anchored infobox attribute data from the Wikipedia history of revisions. By mining (attribute, value) pairs from the revision history of the English Wikipedia we are able to collect a comprehensive knowledge base that contains data on how attributes change over time. When dealing with the Wikipedia edit history, vandalic and erroneous edits are a concern for data quality. We present a study of vandalism identification in Wikipedia edits that uses only features from the infoboxes, and show that we can obtain, on this dataset, an accuracy comparable to a state-of-the-art vandalism identification method that is based on the whole article. Finally, we discuss different characteristics of the extracted dataset, which we make available for further study.