gebhart/patrepeval huggingface dataset:
RADTHYR: an open-label, single-arm, prospective multicenter phase II trial of Radium-223 for the treatment of bone metastases from radioactive iodine refractory differentiated thyroid cancer (2021)

NCT02390934. Registration date 18.03.2015.
Synthesis of Multifunctionalized 1,2,3,4‐Tetrahydropyridines, 2,3‐Dihydropyridin‐4(1H)‐ones, and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N‐Formylmethyl‐Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Application (2013)

Tandem reactions for the efficient synthesis of multifunctionalized 1,2,3,4-tetrahydropyridines, 2,3-dihydropyridin-4(1H)-ones, and pyridine derivatives have been developed and reaction mechanisms have been investigated. Synthetic cascades are initiated by the Zn(OTf)2-mediated [5+1] cycloaddition of N-formylmethyl-substituted tertiary enamides to isocyanides, thus leading to the versatile heterocyclic enamino imine intermediates. Interception of the intermediates by diastereoselective reduction of imine functionality with Me4NBH(OAc)3 afforded 1,6-disubstituted trans-3-hydroxy-4-arylamino- or -alkylamino-1,2,3,4-tetrahydropyridines, whereas acylation of the imino group followed by acidic hydrolysis produced 1,6-disubstituted 3-acyloxy-2,3-dihydropyridin-4(1H)-ones. Aerobic oxidation led to the aromatization followed by intermolecular acyl-group transfer from the pyridinium nitrogen to the 3-hydroxy moiety, thereby yielding substituted 3-acyloxy-4-aminopyridines. Synthetic potentials of the resulting products have been demonstrated by expedient and highly stereoselective synthesis of cis,cis-4,5-dihydroxy-2-phenylpiperidine and trans,trans-4-amino-5-hydroxy-2-phenylpiperidine compounds, which are important in medicinal chemistry, through simple and practical reduction reactions.
Namibian Farmland Cheetahs (Acinonyx jubatus) Demonstrate Seronegativity for Antibodies Against Bacillus anthracis (2016)

<i>African Journal of Wildlife Research</i> is a multidisciplinary journal that has been published since 1971 and covers the scientific, applied, managerial, methodological, and sociological issues related to wildlife research.
DOPAMINERGIC LESIONS AND SUBJECTIVE EFFECTS OF METHYLPHENIDATE IN HUMANS (1992)

Lab. Mol. Neurobiology*, ARC/NIDA; Depts. Neurol. & Neurosci.+, Johns Hopkins Univ. Sch. of Med., Baltimore, Maryland.
MICROCOMPUTERS IN TRANSPORTATION. FEDIT USER INTERFACE FOR FHWA'S TRAF-FRESIM MODEL (1993)

The FEDIT Data Input preprocessor for FHWA's (Federal highway Administration) microscopic freeway simulation program, FRESIM, is described. The latter is a freeway design and operations analysis tool capable of analyzing, in great detail, large complex, or unusual freeway geometric configurations, and can help identify complicated and detailed interactions among different design, control, and traffic variables. It is noted that an efficient method of preparing the input data, while minimizing data input errors and the typical 'code-execute-debug' cycle, is thorugh the use of FRESIM Freeway EDITor program -FEDIT.
Multi-agent Motion Planning for Dense and Dynamic Environments via Deep\n Reinforcement Learning (2020)

This paper introduces a hybrid algorithm of deep reinforcement learning (RL)\nand Force-based motion planning (FMP) to solve distributed motion planning\nproblem in dense and dynamic environments. Individually, RL and FMP algorithms\neach have their own limitations. FMP is not able to produce time-optimal paths\nand existing RL solutions are not able to produce collision-free paths in dense\nenvironments. Therefore, we first tried improving the performance of recent RL\napproaches by introducing a new reward function that not only eliminates the\nrequirement of a pre supervised learning (SL) step but also decreases the\nchance of collision in crowded environments. That improved things, but there\nwere still a lot of failure cases. So, we developed a hybrid approach to\nleverage the simpler FMP approach in stuck, simple and high-risk cases, and\ncontinue using RL for normal cases in which FMP can't produce optimal path.\nAlso, we extend GA3C-CADRL algorithm to 3D environment. Simulation results show\nthat the proposed algorithm outperforms both deep RL and FMP algorithms and\nproduces up to 50% more successful scenarios than deep RL and up to 75% less\nextra time to reach goal than FMP.\n
Cross-Disorder Genomewide Analysis of Schizophrenia, Bipolar Disorder, and Depression (2010)

This study provides the first genomewide significant evidence implicating variants near the ADM gene on chromosome 11p15 in psychopathology, with effects that appear to be specific to bipolar II disorder. Although genomewide significant evidence of cross-disorder effects was not detected, the results provide evidence that there are both pleiotropic and disorder-specific effects on major mental illness and illustrate an approach to dissecting the genetic basis of mood and psychotic disorders that can inform future large-scale cross-disorder GWAS analyses.
Impact of tozinameran (BNT162b2) mRNA vaccine on kidney transplant and chronic dialysis patients: 3–5 months follow-up (2022)

Dialysis patients, and more strikingly kidney transplant recipients, mounted reduced antibody response to COVID-19 mRNA vaccination. Lesser humoral response was associated with more infections. Measures to identify and protect non-responsive patients are required.
Primary Current Distribution on a Sinusoidal Profile (1980)

The primary current distribution at a sinusoidal profile has been solved as a perturbation problem in the amplitude‐to‐wavelength parameter. The results are also applicable to diffusion‐limited reactions on sinusoidal surfaces. The solution for the potential has been developed to the fourth order term. Wagner's solution to this problem can be recovered by including only the first two terms in the perturbation expansion. The expansion technique enables an estimate of the error caused by the neglected terms. The leveling efficiency of a mass‐transfer controlled dissolution reaction is predicted to be always less than that given by Wagner's equation. Applications of the perturbation technique to other relevant problems are discussed.
The effect of saline water on quantitative and qulaitive charactristics of melon genotypes (2017)

Abstarct
Currently, development salt tolerant cultivars is one of the most effective methods to increase efficiency of saline soils and water resources in arid and semi-arid regions of the world. In this regard, the effect of saline water (6.2 and 12 dS m-1) was investigated on yield and qualitative characteristics of 9 commercial melon genotypes (Daregazy, Khaghani, Ghasri, Jafarabady, Bandi, Chahpaliz, Honydew, Ananas melon and Abbas shuri) in Abbas-Abad Research Station in 2006 and 2007. The maximum (18.56 ton ha-1) and minimum (8.55 ton ha-1) fruit yields were obtained from Jafarabady and Daregazy genotypes irrigated with 6.2 dS m-1 saline water, respectively. Daregazy and Abbas shuri showed the maximum (15.67%) and minimum (11.17%) sugar percentage, respectively. Although melon genotypes responded to salinity in different ways, fruit yield decreased with increasing salinity level in all genotypes. When melon genotypes were irrigated with 12 dS m-1 saline water, the maximum (8.71 ton ha-1) and minimum (5.56 ton ha-1) fruit yields were obtained from Jafarabady and Daregazy, respectively, suggesting that these genotypes are the most salt tolerant and salt sensitive genotypes in term of fruit yield. Sugar percentage in Daregazy, Jafarabady, Bandi and Ananas melon genotypes decreased with increasing salinity level, whereas sugar percentage increased in Khaghani, Ghasri, Chahpaliz, Honydew and Abbas shuri genotypes.
Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms (2016)

Blue light shows great promise as a novel decontamination strategy for the nosocomial environment, as well as additional wider decontamination applications (e.g., wound closure during surgery). This warrants further investigation.
Layered holographic stereogram based on inverse Fresnel diffraction (2016)

We propose an efficient algorithm using layered holographic stereogram for three-dimensional (3D) computer-generated holograms. The hologram is spatially partitioned into multiple holographic elements (hogels) to provide the occlusion effect and motion parallax by use of multiple viewpoint rendering. Each hogel is calculated with inverse Fresnel diffraction by slicing the viewing frustum according to the depth image. The sliced layers can provide accurate depth cues for reconstruction since the geometric information of the 3D scene is faithfully matched. The algorithm is compatible with computer graphics rendering techniques and robust for holograms with different parameters. When the hogel size equals 1 mm, the signal-to-noise ratio of the diffraction calculation is above 39 dB with a propagation distance longer than 10 mm. Numerical simulations and optical experiments have demonstrated that the proposed method can reconstruct quality 3D images with reduced computational load.
Abstract 17154: Impact of Myocardial Bridging on Coronary Endothelial Dysfunction and Atherosclerotic Plaque Formation (2013)

Background: Recent studies have demonstrated that myocardial bridging (MB) can cause adverse outcomes, presumably resulted from hemodynamic disturbance that leads to endothelial dysfunction at the ...
Effects of Combined Chelation Treatment with Pyridoxal Isonicotinoyl Hydrazone (PIH) Analogs and Deferoxamine in Hypertransfused Rats and in Iron-Loaded Rat Heart Cells Running Head: Combined PIH analog and DFO Chelation Treatment Heading: Red Cells (2017)

Gabriela Link , Prem Ponka, Abraham M Konijn, William Breuer, Z Ioav Cabantchik and Chaim Hershko . Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School, Department of Biological Chemistry, Institute of Life Sciences, and Department of Medicine, Shaare Zedek Medical Center, Hebrew University of Jerusalem , Jerusalem, Israel and Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
RAGE, Receptor of Advanced Glycation Endoproducts, Negatively Regulates Chondrocytes Differentiation (2014)

RAGE, receptor for advanced glycation endoproducts (AGE), has been characterized as an activator of osteoclastgenesis. However, whether RAGE directly regulates chondrocyte proliferation and differentiation is unclear. Here, we show that RAGE has an inhibitory role in chondrocyte differentiation. RAGE expression was observed in chondrocytes from the prehypertrophic to hypertrophic regions. In cultured cells, overexpression of RAGE or dominant-negative-RAGE (DN-RAGE) demonstrated that RAGE inhibited cartilaginous matrix production, while DN-RAGE promoted production. Additionally, RAGE regulated Ihh and Col10a1 negatively but upregulated PTHrP receptor. Ihh promoter analysis and real-time PCR analysis suggested that downregulation of Cdxs was the key for RAGE-induced inhibition of chondrocyte differentiation. Overexpression of the NF-κB inhibitor I-κB-SR inhibited RAGE-induced NF-κB activation, but did not influence inhibition of cartilaginous matrix production by RAGE. The inhibitory action of RAGE was restored by the Rho family GTPases inhibitor Toxin B. Furthermore, inhibitory action on Ihh, Col10a1 and Cdxs was reproduced by constitutively active forms, L63RhoA, L61Rac, and L61Cdc42, but not by I-κB-SR. Cdx1 induced Ihh and Col10a1 expressions and directly interacted with Ihh promoter. Retinoic acid (RA) partially rescued the inhibitory action of RAGE. These data combined suggests that RAGE negatively regulates chondrocyte differentiation at the prehypertrophic stage by modulating NF-κB-independent and Rho family GTPases-dependent mechanisms.
Geostatistical Analysis of Soil Chemical Properties of Large Land Areas. I. Semi‐variograms (1982)

Abstract Soil properties are usually sampled on some grid or pattern which presumes to represent the unsampled neighborhood. Spatial dependence is a measure of the extent a soil sample represents the unsampled neighborhood. Geostatistics provides procedures to measure spatial dependence. Eighty pedons (Andepts) on the Island of Hawaii were sampled and spatial dependence was measured with semi‐variograms. Areas of soil with similar properties (zones of influence) were delineated by the “range” of the semi‐variogram. Areas of similarity were much greater for soil properties of the 0‐ to 15‐cm depth than of the 30‐ to 45‐cm depth. The ranges of the semi‐variograms for soil pH, Ca, Mg, K, Si, and P sorbed at 0.02 mg P/L were 32 to 42 km while the range of the variogram of rainfall had a similar value of 32 km. Semi‐variograms for Ca, Mg, K, and P based on 30 to 45‐cm‐depth samples demonstrated much greater variability and had smaller zones of influence (Ca, Mg, and K) or were extremely variable (P). Silicon in saturation extract, however, had the same zone of influence in the subsoil as in the topsoil. These results suggest that rainfall has imposed a degree of uniformity on the surface soil properties not apparent in the subsoil. Subsoil properties were highly variable, as might be expected, resulting from great variation over short distances in age and weathering of volcanic ash. The results suggest that soil chemical properties may be spatially dependent and that the spatial dependence in this example represents the imprint of soil‐forming processes and perhaps management. Zones of influence as delineated by semi‐variograms of soil properties may suggest groupings for soil management or soil classification.
Dynamic Topic Mapping Using Latent Semantic Indexing (2005)

This paper proposes an approach to provide a dynamic multipoint view of textual documents based on summarization in arbitrary scale in order to produce topic maps. Our approach is based on the latent semantic indexing (LSI) to deal with synonymy and polysemy. Textual resources are decomposed into a set of sentences and then summarized by a set of sentences that are similar to the view of user. A document may have various summaries and by consequence several topic maps according different user interests. The advantage of our method is to be independent to the language used in the source text. Our experimentation shows that the summary text can contains the sentences whose words are different from those used in the user view but their meanings are close to those used in the user point of view
Profiling of circulating tumor DNA in plasma of non‐small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells (2019)

Abstract Cell‐free plasma DNA (cfDNA) and mimicking circulating tumor cells (mCTCs) have demonstrated tremendous potential for molecular diagnosis of cancer and have been rapidly implemented in specific settings. However, widespread clinical adoption still faces some obstacles. The purpose was to compare the performance of a BEAMing (beads, emulsion, amplification, and magnetics) assay (OncoBEAM™‐epidermal growth factor receptor [ EGFR ] [Sysmex Inostics]) and a next‐generation sequencing assay (NGS; 56G Oncology panel kit, Swift Bioscience) to detect the p.T790M EGFR mutation in cfDNA of non‐small cell lung cancer (NSCLC) patients. CfDNA samples (n = 183) were collected within our hospital from patients having a known EGFR sensitizing mutation, and presenting disease progression while under first‐line therapy. EGFR mutations were detected using NGS in 42.1% of samples during progression in cfDNA. Testing using the OncoBEAM™‐ EGFR assay enabled detection of the p.T790M EGFR mutation in 40/183 NSCLC patients (21.8%) versus 20/183 (10.9%), using the NGS assay. Samples that were only positive with the OncoBEAM™‐ EGFR assay had lower mutant allelic fractions (Mean = 0.1304%; SD ± 0.1463%). In addition, we investigated the detection of p.T790M in mCTCs using H1975 cells. These cells spiked into whole blood were enriched using the ClearCellFX1 microfluidic device . Using the OncoBEAM™‐ EGFR assay, p.T790M was detected in as few as 1.33 tumoral cells/mL. Overall, these findings highlight the value of using the OncoBEAM™‐ EGFR to optimize detection of the p.T790M mutation, as well as the complementary clinical value that each of the mutation detection assay offers: NGS enabled the detection of mutations in other oncogenes that may be relevant to secondary resistance mechanisms, whereas the OncoBEAM™‐ EGFR assay achieved higher sensitivity for detection of clinically actionable mutations.
Some considerations of methodology and standardization of apolipoprotein B immunoassays. (1983)

Abstract Apolipoprotein B, the major protein component of very-low-density (VLDL) and low-density (LDL) lipoproteins in serum, is being widely measured in serum, to help assess risk of cardiovascular disease. Standardization has proven difficult because of the physical and immunochemical heterogeneity of LDL and VLDL, the masking of antigenic determinants of LDL and VLDL, the insolubility of apolipoprotein B, the instability of lipoprotein reference materials, and the multiplicity of analytical methods. Here we have examined the literature and collected current information from lipoprotein scientists to determine the problems--and the ways investigators have attempted to solve them--in preparation, storage, and use of standards and anti-apolipoprotein B sera, analytical procedures and reagents, and the nature of apolipoprotein B in serum. Standardization appears possible with development of stable reference materials that are applicable to the various analytical methods, controlled immunochemical reaction conditions, and establishment of a selected interim reference method for use as a point of reference.
High quality pseudomorphic InGaAs/GaAs HFET structures grown by MBE (1990)

The growth of modulation-doped heterojunction-field effect transistor structures with a pseudomorphic InGaAs quantum well for high frequency device applications is reported. The In-concentrations are varied between 10% and 30%. The quantum well widths range from 8 nm to 16 nm. Depending on the sheet concentration one or two strong photoluminescence transitions with a high-energy cutoff are observed from the two-dimensional electron gas in the InGaAs channel. The transition energies shift to lower energies with higher In-concentration and/or larger quantum well width.
Progressive Multifocal Leukoencephalopathy in HIV-Infected Patients in the Era of HAART: Radiological Features at Diagnosis and Follow-Up and Correlation with Clinical Variables (2008)

The magnetic resonance (MR) imaging patterns of HIV-infected patients affected by progressive multifocal leukoencephalopathy (PML) in the HAART era have not been extensively documented. The aim of the present study is to describe the MR features of PML in HIV-infected patients at diagnosis, and the evolution during follow-up, evaluating the impact of HAART on imaging, and to correlate the MR pattern with the virological and immunological levels and with survival. We retrospectively reviewed MR imaging at baseline and at the last available follow-up within 6 months of diagnosis (median 4 months, range 1-6) of 31 HIV-positive patients affected by PML. A closer follow-up [median interval from diagnosis 39 days (range 20-139)] was also reported. At the onset of neurological disorder, 19 patients were naive for antiretroviral therapy, 7 patients were on HAART, and 5 patients were experienced but were not taking antiretroviral therapy. Upon PML diagnosis no significant differences at imaging were observed between naive and experienced patients and HAART-treated or non-HAART-treated patients. MR findings were not related to immunological status, either at baseline or at follow-up. A radiological improvement within 6 months was associated with a higher probability of a more favorable clinical evolution [OR 14.0 (2.2-87.2), p = 0.003]. The overall probability of survival at 6 months was 61.5%. A better survival was observed in patients with stable or improved MR imaging findings within 6 months [HR 4.55 (95%CI 1.36-15.19, p = 0.009]. Although HAART prolonged the survival of HIV-positive patients affected by PML, it did not seem to influence the PML MR pattern of presentation and the imaging evolution. Only the radiological outcome was predictive of clinical outcome.
West Nile Virus Infection in Plasma of Blood and Plasma Donors, United States (2009)

This study investigated the association of ongoing West Nile virus (WNV) infections with neutralizing antibody titers in US plasma-derived intravenous immune globulin released during 2003-2008. Titers correlated closely with the prevalence of past WNV infection in blood donors, with 2008 lots indicating a prevalence of 1%.
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase (2005)

(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis. We have investigated the selectivity of (R)-roscovitine using three different methods: 1) testing on a wide panel of purified kinases that, along with previously published data, now reaches 151 kinases; 2) identifying roscovitine-binding proteins from various tissue and cell types following their affinity chromatography purification on immobilized roscovitine; 3) investigating the effects of roscovitine on cells deprived of one of its targets, CDK2. Altogether, the results show that (R)-roscovitine is rather selective for CDKs, in fact most kinases are not affected. However, it binds an unexpected, non-protein kinase target, pyridoxal kinase, the enzyme responsible for phosphorylation and activation of vitamin B6. These results could help in interpreting the cellular actions of (R)-roscovitine but also in guiding the synthesis of more selective roscovitine analogs.
Multiple-sound-source localization scheme based on feedback-architecture source separation (2009)

The problem of multiple-sound-source localization in a reverberant environment is investigated in this work, which is a critical technique in video conference applications and is still a challenging task in audio signal processing. In this study, sound signals are first estimated and separated from the mixtures received by a microphone array under a feedback architecture using the blind source separation algorithm. The parameters of time delay of arrival associated with microphones are calculated from the mixtures and estimated source signals by the time-domain cross correlation technique. Finally, the positions of sound sources are derived by the spatial position determination formulas. Experimental results demonstrate that the proposed scheme can effectively determine the locations of multiple sound sources in a near-field and reverberant environment. The direction prediction using the proposed scheme is very promising.
HIGH-DENSITY TUNGSTEN SPHERES. (1968)

yttrium oxide in solid solution were also prepared. Finally, a 1-pound sample of less than 5- mu UO/sub 2/ containing 10 mole% yttrium oxide was produced. Procedures were developed for applying metallurgically bonded tungsten coatings to the edges of W-U0/sub 2/ cermet fuel elements. These coatings were effective in reducing the U0/sub 2/ loss in high- temperature tests at NASA. Of several techniques examined for producing a halide- free tungsten coating on 30- to 60- mu U0/sub 2/ powder. the most promising were (a) vacuum evaporation of tungsten using electron beam heating, and (b) electrostatically bonding fine WO/sub 2/ powder onto the UO/sub 2/, followed by conversion to tungsten by hydrogen reduction. (auth)