gebhart/patrepeval huggingface dataset:
Nutritional, lifestyle and environmental factors in ocular hypertension and primary open-angle glaucoma: an exploratory case-control study (2012)

These exploratory observations suggest a protective effect of omega-3 fatty acids and a deleterious effect of heavy smoking and professional exposure to pesticides in POAG. This will need to be confirmed in future studies.
Exploring Entity Relations for Named Entity Disambiguation (2011)

Named entity disambiguation is the task of linking an entity mention in a text to the correct real-world referent predefined in a knowledge base, and is a crucial subtask in many areas like information retrieval or topic detection and tracking. Named entity disambiguation is challenging because entity mentions can be ambiguous and an entity can be referenced by different surface forms. We present an approach that exploits Wikipedia relations between entities co-occurring with the ambiguous form to derive a range of novel features for classifying candidate referents. We find that our features improve disambiguation results significantly over a strong popularity baseline, and are especially suitable for recognizing entities not contained in the knowledge base. Our system achieves state-of-the-art results on the TAC-KBP 2009 dataset. 1
Dioxolane-Based Perfluoropolymers with Superior Membrane Gas Separation Properties (2018)

Glassy perfluoropolymers have become an exciting materials platform for membrane gas separation as they define the upper bounds for some gas separations, such as He/H2, He/CH4, and N2/CH4. However, due to the difficulty in synthesis, only a few glassy perfluoropolymers are commercially available, including Teflon AF and Hyflon AD derived from dioxoles and Cytop derived from dihydrofuran. In this study, two perfluoropolymers based on dioxolanes, poly(perfluoro-2-methylene-1,3-dioxolane) (poly(PFMD)) and poly(perfluoro-2-methylene-4-methyl-1,3-dioxolane) (poly(PFMMD)), were synthesized by radical polymerization and characterized thoroughly for physical properties such as glass transition temperature (Tg), d-spacing between polymer chains, and fractional free volume (FFV). The gas permeability and solubility were determined at 35 °C for a series of pure gases in these perfluorodioxolanes and compared with the commercial perfluoropolymers. Poly(PFMD) and poly(PFMMD) exhibit separation properties of He/H2, He/CH4, H2/CH4, H2/CO2, and N2/CH4 near or above the upper bounds in Robeson’s plots, and superior to the commercial perfluoropolymers, despite their similar Tg and FFV. The underlying reasons for the superior gas separation properties in these dioxolane-based perfluoropolymers are discussed.
Nonlinear Optical Harmonic Oscillator Results in Efficient Frequency Conversion (2005)

A resonance phenomenon for nonlinear frequency conversion in a directional coupler can be explained by a driven harmonic-oscillator model. We present this model and extend it to obtain the conditions necessary for efficient third-harmonic generation.
A signature based architecture for Trojan detection (2014)

Trust in the integrated circuit (IC) fabrication industry is an ongoing concern given the trend towards "fabless" design and associated use of third-parties for fabrication. A Hardware Trojan (HT) introduced during fabrication can corrupt an IC's outputs, leak secret information, and yet go undetected by traditional system testing techniques. In this paper we propose an architecture to detect HTs during IC test or at run-time. An HT that would corrupt an IC's output and otherwise proceed undetected will then be rendered useless by this architecture. This approach will therefore discourage the insertion of HTs in the first place. The proposed architecture takes encryption hardware as a paradigmatic case-study and uses digital "signatures" derived from the plaintext to identify if the ciphertext has been corrupted by HTs. We test this methodology through simulation on various types of HTs inserted into a lightweight cryptographic system called "PRESENT"[13]. Our results validate that activated HTs are detected by this methodology.
Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies (2000)

The human herpesvirus entry mediator C (HveC), also known as the poliovirus receptor-related protein 1 (PRR1) and as nectin-1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with such a receptor is an essential step in the process leading to membrane fusion. HveC is a member of the immunoglobulin (Ig) superfamily and contains three Ig-like domains in its extracellular portion. The gD binding site is located within the first Ig-like domain (V domain) of HveC. We generated a panel of monoclonal antibodies (MAbs) against the ectodomain of HveC. Eleven of these, which detect linear or conformational epitopes within the V domain, were used to map a gD binding site. They allowed the detection of HveC by enzyme-linked immunosorbent assay, Western blotting, and biosensor analysis or directly on the surface of HeLa cells and human neuroblastoma cell lines, as well as simian Vero cells. The anti-HveC V-domain MAbs CK6, CK8, and CK41, as well as the previously described MAb R1.302, blocked HSV entry. Their binding to soluble HveC was blocked by the association of gD with the receptor, indicating that their epitopes overlap a gD binding site. Competition assays on an optical biosensor showed that CK6 and CK8 (linear epitopes) inhibited the binding of CK41 and R1.302 (conformational epitopes) to HveC and vice versa. Epitope mapping showed that CK6 and CK8 bound between residues 80 and 104 of HveC, suggesting that part of the gD binding site colocalizes in the same region.
COGNITIVE SUPPORT IN SOFTWARE ENGINEERING TOOLS: A DISTRIBUTED COGNITION FRAMEWORK (2002)

Software development remains mentally challenging despite the continual advancement of training, techniques, and tools. Because completely automating software development is currently impossible, it makes sense to seriously consider how tools can improve the mental activities of developers apart from automating them away. Such mental assistance can be called &amp;quot;cognitive support&amp;quot;. Understanding and developing cognitive support in software engineering tools is an important research issue but, unfortunately, at the moment our theoretical foundations for it are inadequately developed. Furthermore, much of the relevant research has occurred outside of the software engineering community, and is therefore not easily available to the researchers who typically develop software engineering tools. Tool evaluation, comparison, and development are consequently impaired. The present work introduces a theoretical framework intended to seed further systematic study of cognitive support in the field of software engineering tools. This theoretical framework, called RODS, imports ideas and methods from a field of cognitive science called &amp;quot;distributed cognition&amp;quot;. The crucial concept in RODS is that cognitive support can be understood and explained in terms of the computational advantages that are conferred when cognition is redistributed between software developer and their tools and environment. The name RODS, in fact, comes from the four cognitive support principles the framework describes. With RODS in hand, it is possible to interpret good design in terms of how cognition is beneficially rearranged. To make such analyses fruitful, a cognitive modeling framework called HASTI is also proposed. The main purpose of HASTI is to provide an analysis of ways of modifying developer cognition usi...
Abstract 5341: Clinical relevance of metastasis-related miRNAs in early breast cancer. (2013)

Abstract Introduction It was recently demonstrated that miRNAs control breast cancer metastasis by influencing multiple metastatic steps. In this study we firstly evaluated the clinical relevance of specific miRNAs -recently shown to correlate with metastasis in breast cancer by exploring their expression profile in FFPEs samples of early breast cancer patients in respect to the clinical outcome of the patients. Finally, we investigated the correlations between the expression of these selected miRNAs and other parameters such as ER and PR expression. Materials and Methods One hundred and twelve (112) FFPE blocks were obtained from breast tumors of early breast cancer patients (follow-up period of 11 years) and 13 mammoplasty specimens from healthy tissues which were used as controls. The median overall survival (OS) and disease free interval (DFI) were 84 and 68 months respectively. We have chosen to quantify the expression of six metastasis related miRNAs, namely: miR-10b, miR-2,1 miR-205, miR-210, miR-335 and let-7a by RT-qPCR in the LightCycler (Roche). HER2, ER and PR expression of the primary tumors was detected by immunohistochemistry with the monoclonal antibody CB11 and with monoclonal antibodies to ER and PR, respectively, using the OPTIMAX automated system. For all miRNAs relative expression was determined using the ΔCq approach and expression values were normalized to miR-191 which has been shown to be a suitable reference miRNA. Results Kaplan-Meier survival curves demonstrated that patients with high miR-21 expression (n=56) had a significant shorter DFI than those with low miR-21 expression (P=0.043). Moreover, patients with low expression of miR-205 (n=57) had both shorter DFI and OS time than those with high expression levels (P=0.040 and P=0.047 respectively). However, the expression levels of the other four miRNAs were not related with the DFI and OS. We also found that in the ER-negative subgroup (n=46), disease relapse was more common in patients where miR-10b was over-expressed (P=0.019), while in the PR-negative subgroup (n=47), disease relapse was more common in patients with miR-21 overexpression (P&amp;lt;0.001) or miR-10b overexpression (P =0.016). Finally, in the group of PR-negative patients we noticed that patients who overexpressed miR-21 had shorter OS (P=0.021). Conclusions Quantification of metastasis related miRNAs expression in primary tumors can give important prognostic information in patients with early breast cancer. Citation Format: Athina N. Markou, George M. Yousef, Yu Liang, E Stathopoulos, Vassilios Georgoulias, Evi S. Lianidou. Clinical relevance of metastasis-related miRNAs in early breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5341. doi:10.1158/1538-7445.AM2013-5341
REVIEWS OF BOOKS (1962)

Journal Article REVIEWS OF BOOKS Get access The Choral Tradition. By Percy M. Young. pp. 371. ( Hutchinson, London, 1962, 45s.) P. le H. P. le H. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 43, Issue 3, July 1962, Pages 274-a–274, https://doi.org/10.1093/ml/43.3.274-a Published: 01 July 1962
Continuous high throughput nanofluidic separation through tangential-flow vertical nanoslit arrays (2016)

Nanofluidic devices exhibit unique, tunable transport properties that may lead to breakthroughs in molecular separations and sensing. However, the throughput of these devices is orders of magnitude too small for the processing of macroscopic samples. Here we overcome this problem by combining two technological innovations. First, nanofluidic channels are made as vertical slits connecting the two sides of a silicon nitride membrane. Arbitrary arrays of such nanoslits down to 15 nm wide with <6 Å uniformity were made by merging the idea of templating with chemical mechanical polishing to create a scalable, nanolithography-free wafer level process. Second, we provide for efficient solute transport to and from the openings of the nanoslits by incorporating the nanofluidic membrane into a microfluidic tangential-flow system, which is also fabricated at wafer level. As an exemplary application, we demonstrate charge-based continuous flow separation of small molecules with a selectivity of 100 and constant flux over more than 100 hours of operation. This proves the exciting possibility of exploiting transport phenomena governed by precision-engineered nanofluidic devices at a macroscopic scale.
Seasonal trends in house dust mite allergen in children’s beds over a 7‐year period (2007)

House dust mite allergen concentrations in Sydney beds fluctuate approximately two- to threefold on an annual cycle, partly determined by relative humidity, with peaks in late autumn and minima in summer. Fluctuations of this magnitude might be sufficient to influence asthma symptoms.
An Expeditious, Multi-gram Isolation Protocol for the Ultrapotent SERCA Inhibitor Thapsigargin (2007)

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (1a) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
Scintillating Metal‐Organic Frameworks: A New Class of Radiation Detection Materials (2008)

Metal-organic frameworks containing an organic fluorophore such as stilbene dicarboxylate emit prompt visible light when they interact with ionizing radiation (e.g., high-energy protons or alpha particles). A completely new class of scintillation materials is created by this development, with the potential to rationally tailor properties for specific radiation detection applications. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
TURBULENT OSCILLATORY FLOW OVER RIPPLES AT HIGH REYNOLDS NUMBERS FOR PETA-SCALE SIMULATIONS (2018)

Surface waves in the coastal zone induce oscillatory flow motions in the vicinity of the seabed. These wave-induced coastal flows interact with the sandy seabed and modify the bed shape by generating coherent small-scale bed structures, which are generally known as ripples. The presence of ripples in oscillatory flows is important due to the impact they have on the seabed roughness and how they affect the near-bed boundary layer hydrodynamics. Simulations of higher and more real-scale Reynolds number (Re) require the use of supercomputers in order to obtain results in a reasonable amount of time. However, the constant evolution of the computing facilities makes the development of parallel algorithms a rather difficult task. The objective of the proposed research is to advance in the comprehension of coastal processes utilizing high performance computing (HPC) for the numerical simulation of the three-dimensional, turbulent flow, which is induced in the coastal zone by wave propagation. In particular, our CFD code (SimuCoast) has been developed using a hybrid MPI+OpenACC execution model that increases its scalability and allows it to engage the vast majority of high-end supercomputers. Special attention has been paid in the parallelization strategy of the Poisson solver that is the most computational demanding operation.
Codesign Requires Closed-System Specifications. (1999)

When small doses of pindolol and propranolol (0.1 mg/kg and 5 mg/kg, respectively) were administered intraperitoneally to conscious normotensive Kyoto Wistar rats, acute hypotension occurred. However, these hypotensive effects diminished when the doses were increased to 5 mg/kg and 20 mg/kg, respectively. Unilateral adrenalectomy had no effect on these hypotensive effects but they were suppressed by bilateral adrenalectomy. Subsequently, marked and lasting hypotensive effects (20-35 mm Hg) were observed. In urethane-anaesthetized rats, intravenous infusions of the blocking agents produced a rise in blood pressure and an increase in the content of epinephrine, norepinephrine and dopamine in adrenal venous blood. These hypertensive actions were not seen in adrenalectomized rats. When rats were given 6-hydroxydopamine (2 micrograms/microliters) bilaterally at the C4 level of the spinal cord 7 days before or 5,7-dihydroxytryptamine (2 micrograms/microliters, after desmethylimipramine, 25 mg/kg i.p.), the catecholamine content of adrenal venous blood and the catecholamine releasing actions of these blocking agents decreased, but were not completely abolished. These results suggest that the lack of hypotensive effects with higher doses of beta-adrenoceptor blocking agents may have been due partly to the direct release of catecholamines from the adrenal medulla and partly to central noradrenergic or serotonergic nerve action.
Using the Mus musculus hybrid zone to assess covariation and genetic architecture of limb bone lengths (2018)

Two subspecies of the house mouse, Mus musculus domesticus and Mus musculus musculus, meet in a narrow contact zone across Europe. Mice in the hybrid zone are highly admixed, representing the full range of mixed ancestry from the two subspecies. Given the distinct morphologies of these subspecies, these natural hybrids can be used for genomewide association mapping at sufficiently high resolution to directly infer candidate genes. We focus here on limb bone length differences, which is of special interest for understanding the evolution of developmentally correlated traits. We used 172 first-generation descendants of wild-caught mice from the hybrid zone to measure the length of stylopod (humerus/femur), zeugopod (ulna/tibia) and autopod (metacarpal/metatarsal) elements in skeletal CT scans. We find phenotypic covariation between limb elements in the hybrids similar to patterns previously described in Mus musculus domesticus inbred strains, suggesting that the hybrid genotypes do not influence the covariation pattern in a major way. Mapping was performed using 143,592 SNPs and identified several genomic regions associated with length differences in each bone. Bone length was found to be highly polygenic. None of the candidate regions include the canonical genes known to control embryonic limb development. Instead, we are able to identify candidate genes with known roles in osteoblast differentiation and bone structure determination, as well as recently evolved genes of, as yet, unknown function.
Using haptics to probe human contact control strategies for six degree-of-freedom tasks (2014)

Transferring human contact-manipulation skills to robots is complicated by the combinatorial growth in contact state descriptions with object and environment complexity, with no systematic method to characterize the subset of contact states that humans actually control. In this paper, we present an approach to determine whether human subjects control specific contact states. Subjects used a six degree-of-freedom haptic interface to place a box on a plane, and insert L- and S-shaped objects into corresponding holes, while using either their (undetermined) natural strategies or explicitly controlling a pre-specified sequence of contact states. We found that the vast majority of contact states were visited for time periods of less than 40ms, which negates the possibility of human feedback control due to physiological delay limits. Next, using force, moment and velocity trajectories around contact state transitions as a metric, we found that certain states were readily discriminable across natural and explicit control strategies (~ 85%), which indicates that they were not controlled during natural motions. Less discriminable states, in contrast, were likely to have been controlled in both natural and explicit strategies. Our results suggest that humans explicitly control a small subset of contact states, and that their control strategies are reflected in local force and velocity profiles. We thus demonstrate that six degree-of-freedom haptic simulations are effective for characterizing human contact-state invariant control strategies.
048 Retroviral Delivery of A Dominant Negative TGF‐beta Receptor II Mitigates Scar in a Rabbit Model of Scar Hypertrophy (2004)

Effective blockade of the pluripotent cytokine TGF‐beta as a means of cutaneous scar reduction is a strategy with great potential. This desired effect may be achieved through the overexpression of mutant TGF beta receptors within the wound milieu. Our goal was to examine the effects of dominant negative mutant TGF‐beta receptor II (dnTGFRII) protein expression in a well‐established rabbit ear model of hypertrophic scarring. Serial injections of a retroviral construct encoding a truncated TGFβRII and the marker green fusion protein (pMSCV‐rIIdn‐GFP) were performed in 7mm punch wounds at day 10 and day 14 (two‐day injection group) or day 8, 10, 12 (three‐day injection group) post wounding. Delivery of a null vector (pMSCV‐GFP) at the same time points served as a negative control. Histomorphometric analysis of wounds harvested at day 28 revealed a statistically significant reduction (33%) in the scar elevation index in 2‐day treated and a more modest reduction in SEI (17.5%) in the 3‐day treated arm compared to null‐treated controls. Confocal microscopy confirmed stable transfection of the construct in both peri‐wound tissue as well as rabbit dermal fibroblasts transfected in vitro. Optimization of this novel application in retroviral gene therapy could lead to effective anti‐scarring strategies.
Evolving perspectives on the exposure risks from magnetic fields. (1990)

Based on information from suggesting effects of positive and negative polarity on cancer cells, surveys were performed on magnetic resonance imaging devices, as well as other types of equipment capable of producing appreciable magnetic fields. These surveys were performed in areas where there was a potential for both occupational and general public exposure.
Micromechatronics (2003)

Mechatronics-the breakthrough concept in the design and analysis of electromechanical systems and the unified cornerstone of modern engineering. Microsystems-the future of technology, but fraught with the challenges inherent at small scales. Apply the power and versatility of mechatronics to microsystems and we find a way to attack, integrate, and solve a great variety of emerging engineering problems.Micromechatronics: Modelling, Analysis, and Design with MATLAB synthesizes traditional engineering topics and the latest technologies to build a solid understanding of the engineering underpinnings of integrated technologies and develop the modern picture of microelectromechanical engineering. Emphasizing the modeling, simulation, analysis, design, and implementation of high-performance mini-and microscale electromechanical systems, the authors develop the rigorous theory, demonstrate the application of theoretical results, and explore state-of-the-art technologies. MATLAB is used throughout the book to illustrate practical examples and help readers master this powerful, industry-standard software.The application of mechatronics, particularly micromechatronics, is an endless frontier. All engineers will soon need a working knowledge of the theoretical bases and their practical applications. Comprehensive in coverage and global in perspective, Micromechatronics: Modeling, Analysis, and Design with MATLAB helps build the background you need to design and analyze state-of-the-art systems and contribute to further advancements.