gebhart/patrepeval huggingface dataset:
Non‐antithrombin affinity Semuloparin and it's component oligosaccharides release endogenous TFPI in a molecular weight dependent fashion (2012)

Semuloparin (S) is an ultra low molecular weight heparin (uLMWH) with a unique composition. The purpose of this study was to determine the effect of non‐AT affinity semuloparin (NATAS) and it's oligosaccharide components on TFPI release. Non‐human primates (n=4–6; Macaca mulatta) were administered with 1.0 mg/kg IV, S, it's non‐AT affinity fraction and isolated hexasaccharide (H), dodecasaccharide (D) and octasaccharide (O) components. Citrated plasma samples were drawn at baseline and 15 minutes post‐administration. TFPI antigen levels by ELISA and tissue factor mediated thrombin generation using a fluorogenic assay were measured. S produced a sizable release of TFPI (156 ± 15 ng/ml). NATAS produced a slightly lower but statistically significant release of TFPI (142 ± 12 ng/ml). The oligosaccharide components produced a molecular weight dependent release of TFPI, with H producing minimal TFPI release (86 ± 8 ng/ml) vs. saline (78 ± 9 ng/ml). D produced a statistically significant increase in the release of TFPI (116+15 ng/ml). While S exhibited a measurable anti‐Xa response and produced a strong inhibition of thrombin generation (84% inhibition) whereas NATAS and it's fractions produced &lt; 20% inhibition of thrombin generation. These results suggest that the NATAS and it's oligosaccharide components enhance TFPI antigen release which may mediate some of it's pharmacodynamic actions.
Evidence for Transcriptional Factor Dysregulation in the Dorsal Raphe Nucleus of Patients with Major Depressive Disorder (2012)

Extensive evidence implicates dysfunction in serotonin (5-HT) signaling in the etiology of major depressive disorder (MDD). Dorsal raphe nucleus (DR) is a major source of serotonin in the brain, and previous studies have reported within it alterations in 5-HT-related gene expression, protein levels, receptor binding, and morphological organization in mood disorders. In the present study, we utilized in situ hybridization-guided laser capture microdissection to harvest tissue samples from the middle-caudal subregion of the human DR post-mortem from MDD patients and from psychiatrically normal comparison subjects. Extracted RNA was prepared for gene expression profiling, and subsequent confirmation of select targets with quantitative real-time PCR. Our data indicate expression changes in functional gene families that regulate: (1) cellular stress and energy balance, (2) intracellular signaling and transcriptional regulation, and (3) cell proliferation and connectivity. The greatest changes in expression were observed among transcriptional regulators, including downregulation in the expression of TOB1, EGR1, and NR4A2 and their downstream targets. Previous studies have implicated these gene products in the regulation of functional domains impacted by MDD, including cognitive function, affective regulation, and emotional memory formation. These observations indicate altered function of several transcriptional regulators and their downstream targets, which may lead to the dysregulation of multiple cellular functions that contribute to the pathophysiology of MDD. Future studies will require single cell analyses in the DR to determine potential impact of these changes on its cellular functions and related circuits.
The diffusion and toxicity of the fumigant chloropicrin injected in sugar maple and white birch tree (1987)

Twenty sugar maple (Acersaccharum Marsh.) and 20 white birch trees (Betulapapyrifera Marsh.), all containing columns of decayed or discolored wood, were bored and injected with one of three dosages of chloropicrin or were left untreated. One year after treatment, four trees of each species were felled and dissected. The wood was then analyzed for fumigant concentration and assayed for the presence of fungi. All remaining trees were inspected yearly for adverse response to treatment. Three years after treatment, dieback and leaf discoloration were apparent in birch trees treated with moderate to high dosages of chloropicrin. No adverse response to treatment was apparent in any maple tree or in birch trees treated with low dosages of chloropicrin. In the dissected trees, chloropicrin vapors were generally detected in the interior of the trees at sites 0.5 m above and 0.5 m below the treatment site. In the higher dosage birch trees, chloropicrin was detected more frequently and in higher concentrations from outer sapwood. Control of the causal decay fungi in the trees was not ascertained in this study; however, in the birch trees, growth of opportunistic decay fungi was inhibited in sections from treated but not untreated trees.
Avalanche photodiode frequency response (1967)

Short circuit photocurrent of avalanche photodiode, determining frequency response and multiplication effect on bandwidth
Carrier aggregation for LTE-advanced mobile communication systems (2010)

In order to achieve up to 1 Gb/s peak data rate in future IMT-Advanced mobile systems, carrier aggregation technology is introduced by the 3GPP to support very-high-data-rate transmissions over wide frequency bandwidths (e.g., up to 100 MHz) in its new LTE-Advanced standards. This article first gives a brief review of continuous and non-continuous CA techniques, followed by two data aggregation schemes in physical and medium access control layers. Some technical challenges for implementing CA technique in LTE-Advanced systems, with the requirements of backward compatibility to LTE systems, are highlighted and discussed. Possible technical solutions for the asymmetric CA problem, control signaling design, handover control, and guard band setting are reviewed. Simulation results show Doppler frequency shift has only limited impact on data transmission performance over wide frequency bands in a high-speed mobile environment when the component carriers are time synchronized. The frequency aliasing will generate much more interference between adjacent component carriers and therefore greatly degrades the bit error rate performance of downlink data transmissions.
Pegfilgrastim on the Same Day Versus Next Day of Chemotherapy in Patients With Breast Cancer, Non–Small-Cell Lung Cancer, Ovarian Cancer, and Non-Hodgkin's Lymphoma: Results of Four Multicenter, Double-Blind, Randomized Phase II Studies (2010)

For patients receiving pegfilgrastim with chemotherapy, pegfilgrastim administered 24 hours after chemotherapy completion is recommended.
Mobile ad hoc networking and the IETF (2006)

This article is part of a continuing series to discuss ongoing activities within the mobile ad hoc networking (MANET) working group (WG) of the IETF. This article provides a brief overview of recent events.
SNR-Aware Power Allocation Scheme for Lossy-Forward Relaying Systems (2018)

In a recent work, we proposed a simple and efficient power allocation scheme for a dual-hop communication system with multiple lossy-forward relays. In this letter, we propose a less simple, yet more efficient and comprehensive power allocation scheme for the referred system. Unlike our previous approach, which was based on an asymptotic reasoning at high signal-to-noise ratio, the new one optimizes the allocation policy according to any particular amount of total transmit power. The more constrained that amount of power, the more advantageous the new scheme.
A Shock-Tube Study of the Rate Constant of PH3 + M ⇄ PH2 + H + M (M = Ar) Using PH3 Laser Absorption (2020)

Phosphine (PH<sub>3</sub>) is a highly reactive and toxic gas. Prior experimental investigations of PH<sub>3</sub> pyrolysis reactions have included only low-temperature measurements. This study reports the first shock-tube measurements of PH<sub>3</sub> pyrolysis using a new PH<sub>3</sub> laser absorption technique near 4.56 μm. Experiments were conducted in mixtures of 0.5% PH<sub>3</sub>/Ar behind reflected shock waves at temperatures of 1460-2013 K and pressures of ∼1.3 and ∼0.5 atm. The PH<sub>3</sub> time histories displayed two-stage behavior similar to that previously observed for NH<sub>3</sub> decomposition, suggesting by analogy that the rate constant for PH<sub>3</sub> + M ⇄ PH<sub>2</sub> + H + M (R1) could be determined. A simple three-step mechanism was assembled for data analysis. In a detailed kinetic analysis of the first-stage PH<sub>3</sub> decomposition, values of <i>k</i><sub>1,0</sub> were obtained and best described by (in cm<sup>3</sup>·mol<sup>-1</sup>·s<sup>-1</sup>) <i>k</i><sub>1,0</sub> = 7.78 × 10<sup>17</sup> exp(-80,400/<i>RT</i>), with units of cal, mol, K, s, and cm<sup>3</sup>. Agreement between the 1.3 and 0.5 atm data confirmed that the measured <i>k</i><sub>1,0</sub> was in the low-pressure limit. Agreement of the experimental <i>k</i><sub>1,0</sub> with ab initio estimates resolved the question of the main pathway of PH<sub>3</sub> decomposition: it proceeds as PH<sub>3</sub> ⇄ PH<sub>2</sub> + H instead of PH<sub>3</sub> ⇄ PH + H<sub>2</sub>.
Production of Bio-Oil from Biomass: Slow Pyrolysis of Rapeseed (Brassica napus L.) in a Fixed-Bed Reactor (2003)

Rapeseed (Brassica napus L.) pyrolysis experiments were performed in a fixed-bed reactor. The effects of heating rate, final pyrolysis temperature, particle size, and pyrolysis atmosphere on pyrolysis product yields and chemical compositions have been investigated. The maximum oil yield of 51.7% was obtained at a pyrolysis temperature of 550°C with particle sizes in the range of +0.6 to 1.8 mm in a sweeping gas atmosphere (100 cm3 min−1 N2) and a heating rate of 30°C min−1. The chemical characterization has shown that the oil obtained from rapeseed may be potentially valuable as fuels and chemical feedstocks.
Immediate Postoperative Complications in DIEP versus Free/Muscle-Sparing TRAM Flaps (2007)

In the authors' series, the use of the DIEP flap did not result in more postoperative flap-related complications when compared with the free/muscle-sparing TRAM flap. Furthermore, no patient characteristics were statistically associated with a more successful result. The authors conclude that in patients whose anatomy reveals perforators of adequate size, the DIEP flap is a safe and reliable procedure for breast reconstruction.
Cardiovascular catheters and accessories: Ex vivo testing of ferromagnetism, heating, and artifacts associated with MRI (1998)

The purpose of this study was to evaluate the MR safety of cardiovascular catheters and accessories. Intravascular cardiovascular catheters and accessories were tested for MR safety at 1.5 T using previously described techniques with respect to the evaluation of magnetic field attraction (deflection angle method), heating (temperature measured immediately before and after performing MRI), and artifacts (using a fast spoiled gradient-recalled acquisition in steady state [GRASS] pulse sequence). Two devices were attracted (RV pacing lead and Oximetrix 3 SO2 optical module) by the static magnetic field. Each of the other objects displayed no attraction. Heating was +0.2 degrees C for the sample cardiovascular catheter tested (Opticath). Artifacts varied from moderate to severe, depending on the amount and type of metal present in the device. Despite these ex vivo test results, further safety consideration should be given to the cardiovascular devices that have a conductive wire component (ie, certain types of the cardiovascular catheters) because of the potential for inducing current and excessive heating in these devices during MRI, especially using a high-field-strength MR system. The cardiovascular catheters evaluated in this study or those with a similar design are not recommended for use in patients undergoing MRI procedures.
Nitroglycerin, nitroprusside, or both, in preventing radial artery spasm during transradial artery catheterization. (2006)

In this prospective, randomized trial, the addition of a direct nitric oxide donor to nitroglycerin in an antispastic cocktail did not reduce the risk of spasm, and the use of nitroglycerin was found to be as effective as nitroprusside. Also, morphometric and mechanical factors play a significant role in predicting the occurrence of radial spasm. The sex of the patient, presence of diabetes, body surface area and smoking history appeared to play no role in predicting the occurrence of radial spasm.
Temperature Control Of A Water Bath Process: A Comparative Study Between Neuro-Control, A Self-Tuning Adaptive Control, A Generalised Predictive Control, And A Conventional Feedback Control Approach (1991)

Currently, neural networks are being used to solve problem related to control. One way to determine the reliability of the neuro-control technique is to test it on a variety of realistic problems, and to compare directly with existing traditional control technique, to see whether it works well and where it needs further refinement. In this article, we compare the neuro-control approach to a self-tuning adaptive control approach, a generalised predictive control approach, and a conventional feedback control approach on a real-time process control system. The neuro-control scheme consists of a backpropagation through time utility where two neural networks are trained one as an emulator, and the other as a controller. The four systems are compared conceptually and through experimental studies on the same single-input single-output water bath temperature control process. Comparisons, where applicable, are made with respect to methodology, system tracking performance, speed of adaptation, disturbance rejection, effect of long time-delay, and noise rejection. The results show that the neural network controller performs very well and offers encouraging advantages in many aspects over the other three controllers.
Stress corrosion cracking and hydrogen embrittlement susceptibility studies on modified 9Cr-1Mo steel weldments in acidic and neutral media (1996)

There is much scope for the development of new engineering materials for high temperature applications such as for tubing used in steam generation in fossil fuel and nuclear power plants and in petrochemical cracking units. The materials for such applications are often manufactured from mild steel and low alloy ferritic steels containing up to 9%Cr. Modified 9Cr-1Mo ferritic steel, prepared by incorporating vanadium and niobium, is one of the newer materials extensively used for high temperature applications. A study of weldments of this alloy and its susceptibility to stress corrosion cracking (SCC) and hydrogen embrittlement was carried out in acidic and neutral media. The anodic behaviour of modified 9Cr-1Mo under 90% proof stress was also examined. Mechanical properties of the material were assessed before and after SCC and hydrogen embrittlement tests. The SCC tests were made at various anodic potentials in 1M H 2 SO 4 and showed that the welded alloy is not susceptible to SCC in all three critical zones. The alloy was, however, susceptible to SCC in chloride environments, namely a solution containing equal volumes of 1M NaCl and 1M MgCl 2 . Fractographic analysis was carried out to determine the reasons for the failure of this alloy. The hydrogen embrittlement studies in 1M H 2 SO 4 showed that the alloy is prone to delayed hydrogen cracking at more negative potentials. The fractographic examination using scanning electron microscopy revealed the presence of adsorbed hydrogen in microvoids which were responsible for the failure of the alloy. Other possible reasons for the failure of the alloy are also discussed.
Sulfated poly-amido-saccharides (sulPASs) are anticoagulants in vitro and in vivo (2021)

Anticoagulant therapeutics are a mainstay of modern surgery and of clotting disorder management such as venous thrombosis, yet performance and supply limitations exist for the most widely used agent - heparin. Herein we report the first synthesis, characterization, and performance of sulfated poly-amido-saccharides (sulPASs) as heparin mimetics. sulPASs inhibit the intrinsic pathway of coagulation, specifically FXa and FXIa, as revealed by <i>ex vivo</i> human plasma clotting assays and serine protease inhibition assays. sulPASs activity positively correlates with molecular weight and degree of sulfation. Importantly, sulPASs are not degraded by heparanases and are non-hemolytic. In addition, their activity is reversed by protamine sulfate, unlike small molecule anticoagulants. In an <i>in vivo</i> murine model, sulPASs extend clotting time in a dose dependent manner with bleeding risk comparable to heparin. These findings support continued development of synthetic anticoagulants to address the clinical risks and shortages associated with heparin.
Facteurs physico-chimiques de l'accumulation des formations travertineuses (1986)

Dans cette note de synthèse, on présente le jeu des différents facteurs au niveau local (biotope) et au niveau du géosystème ou de l'hydrosystème : massifs karstiques, sources et rivières qui en sont issues. On analyse particulièrement le problème des changements dans le chimisme de l'eau, au cours de l'Holocène et actuellement, en fonction des activités an thropiques.
Monoclonal antibodies that inhibit IgE binding. (1986)

Four monoclonal antibodies were produced that inhibit IgE binding to the high affinity IgE receptor (Fc epsilon R) on rat basophilic leukemia cells. The four monoclonal antibodies (mAb) fall into two groups. The first group was comprised of 3 antibodies (mAb BC4, mAb CD3, and mAb CA5) that reacted with the Fc epsilon R at epitopes close or identical to the IgE-binding site. With 125I-labeled antibodies there was reciprocal cross-inhibition between the antibodies and IgE. The antibodies activated both RBL-2H3 cells and normal rat mast cells for histamine release. The 3 antibodies immunoprecipitated the previously described alpha, beta, and gamma components of the receptor. The number of radiolabeled Fab fragments of 2 of these antibodies bound per cell was similar or equal to the number of IgE receptors. In contrast, the mAb BC4 Fab bound to 2.1 +/- 0.4 times the number of IgE receptor sites. Therefore, the portion of the Fc epsilon R exposed on the cell surface must have two identical epitopes and an axis of symmetry. These 3 monoclonal antibodies recognize different but closely related epitopes in the IgE-binding region of the Fc epsilon R. The fourth monoclonal antibody (mAb AA4) had different characteristics. In cross-inhibition studies, IgE and the other 3 monoclonals did not inhibit the binding of this 125I-labeled monoclonal antibody. The number of molecules of this antibody bound per cell was approximately 14-fold greater than the Fc epsilon R number. This monoclonal antibody caused the inhibition of histamine release and it appears to bind to several cell components.
Content management policies in peer-to-peer file sharing networks (2005)

Peer-to-peer (P2P) file sharing applications consist of nodes that share part of their local memory. A node can download a file (also called content) from another node participating to the P2P community, and must allow others to download files stored in its own shared local memory. Since nodes join and leave the P2P community at their will in an uncoordinated way, copies of the same file must be stored in many nodes. By means of this redundancy, the probability that a given content cannot be retrieved because all nodes storing it are temporary inactive can be kept small. Content management policies are the distributed strategies implemented at the nodes to decide the set of files to be stored in the local memory. In this paper, we propose, analyze and compare different content management policies. The considered performance indices include the probability that content cannot be retrieved due to lack of available copies of the content, and the amount of traffic generated in the network.
Environmental Toxicology of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans (1993)

John P. Vanden Heuvel, George Lucier, Environmental Toxicology of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans, Environmental Health Perspectives, Vol. 100 (Apr., 1993), pp. 189-200
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation (2019)

Several enzymes can simultaneously interact with multiple intracellular metabolites, however, how the allosteric effects of distinct ligands are integrated to coordinately control enzymatic activity remains poorly understood. We addressed this question using, as a model system, the glycolytic enzyme pyruvate kinase M2 (PKM2). We show that the PKM2 activator fructose 1,6-bisphosphate (FBP) alone promotes tetramerisation and increases PKM2 activity, but addition of the inhibitor L-phenylalanine (Phe) prevents maximal activation of FBP-bound PKM2 tetramers. We developed a method, AlloHubMat, that uses eigenvalue decomposition of mutual information derived from molecular dynamics trajectories to identify residues that mediate FBP-induced allostery. Experimental mutagenesis of these residues identified PKM2 variants in which activation by FBP remains intact but cannot be attenuated by Phe. Our findings reveal residues involved in FBP-induced allostery that enable the integration of allosteric input from Phe and provide a paradigm for the coordinate regulation of enzymatic activity by simultaneous allosteric inputs.
Efficient linear-quadratic filtering (1996)

We present two approaches to efficient linear-quadratic (LQ) filtering. The first of these is implemented in the frequency domain and requires less computations than the second (time domain) approach. The savings are similar to those obtained by executing linear filtering in the frequency domain with the use of the Fast Fourier Transform (FFT). The one drawback of the frequency domain method is the delay that is induced that is related to FFT length. A time domain method that does not suffer from this delay problem is subsequently derived. Our time domain approach involves rearranging the LQ filtering structure so that the quadratic part of the system consists of a bank of linear filters that can be run in parallel. The inputs to these linear filters are products of the original input signal.
Semiintegral electroanalysis. Shapes of neopolarograms (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSemiintegral electroanalysis. Shapes of neopolarogramsMasashi. Goto and Keith B. OldhamCite this: Anal. Chem. 1973, 45, 12, 2043–2050Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ac60334a027https://doi.org/10.1021/ac60334a027research-articleACS PublicationsRequest reuse permissionsArticle Views333Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts