gebhart/patrepeval huggingface dataset:
H-2-Nonrestricted Cytotoxic Responses to an Antigen Encoded Telomeric to H-2D (1979)

Abstract Cytotoxic T lymphocytes (CTL) were generated in secondary in vitro cultures against H-2-identical allogeneic stimulators. In some strain combinations, such as C57BL/10 (B10) responding to C3H.SW, cytolysis was restricted to target cells bearing the H-2 antigens of the immunizing strain. However, B10.BR effectors sensitized to C3H, AKR, or CBA efficiently lysed targets of several H-2 haplotypes, including B10 targets congenic with the B10.BR responders. The activity of these CTL was totally abrogated by anti-Thy 1.2 plus complement. Lysis of 51Cr-labeled B10 targets by B10.BR anti-AKR CTL was inhibited by unlabeled B10 and AKR targets equally well, thus showing that the clones killing B10 are included in the AKR-specific clones. In addition, both B10 and B10.D2 stimulator cells were effective in the in vitro boosting of the B10.BR anti-AKR cytotoxic response. Mapping experiments using B10, B10.A, B10.A(2R), B10.A(5R), C57BL/6, and B6-Tlaa mice indicated that the locus relevant to these phenomena maps to the right of H-2D. Since both Con A and LPS blast targets were susceptible to the activity of the nonrestricted CTL, antigens encoded by this locus are not unique to the T or B cell lineage.
Recovering correct phase information in multiwavelength digital holographic microscopy by compensation for chromatic aberrations (2005)

We demonstrate experimentally that correct phase imaging without 2pi ambiguity is obtainable in digital holography by using a multiwavelength approach in the microscope configuration. We describe a general approach for removing chromatic aberrations and for controlling the pixel size of the reconstructed phase image in multiwavelength digital holography when the Fourier transform method is adopted for the numerical reconstruction of digital holograms. The retrieved phase is affected by the unavoidable, unwanted chromatic aberration. The correct phase can be obtained by evaluating the phase from the reference holograms reconstructed at different wavelengths to compensate for the chromatic aberration.
Manuel Machado y Wagner (con Schopenhauer y Nietzsche) (1997)

Machine learning (ML) interatomic potentials (ML-IAPs) are generated for alkane and polyene hydrocarbons using on-the-fly adaptive sampling and a sparse Gaussian process regression (SGPR) algorithm. The ML model is generated based on the PBE+D3 level of density functional theory (DFT) with molecular dynamics (MD) for small alkane and polyene molecules. Intermolecular interactions are also trained with clusters and condensed phases of small molecules. It shows excellent transferability to long alkanes and closely describes the ab inito potential energy surface for polyenes. Simulation of liquid ethane also shows reasonable agreement with experimental reports. This is a promising initiative toward a universal ab initio quality force-field for hydrocarbons and organic molecules.
Human sensors: Case-study of open-ended community sensing in developing regions (2013)

With the growing number of cities and population, continuous monitoring of city's infrastructure and automated collection of day-to-day events (such as traffic jam) is essential and can help in improving life style of citizens. It is extremely costly and ineffective to install hardware sensors to sense these events in developing regions. Due to advent of smartphones, citizens can play role of sensors and actively participate in collection of the events which can be shared with others for information or can be used in decisions which affects city development. In this paper, we describe an architecture of crowdsensing testbed for capturing and processing events affecting citizens in cities in India. One of the design principle of our testbed is that it encourages users to do an open-ended sensing under five broad categories: Civic complaints, traffic, neighbourhood issues, emergency and others. As part of testbed, we allow events submissions from different submission modes i.e. mobile application, SMSes and web. Our mobile application exploits different sensing interfaces provided by today's smartphones to add contextual data with event reports such as images, audio, fine-grained location etc. Proposed testbed is used by university students across India to report event happening around them. Finally, we describe the data collected and uncover some of challenges and opportunities which may help future designs of crowdsensing based systems.
Tubeimoside V (I), a New Cyclic Bisdesmoside from Tubers of Bolbostemma paniculatum, Functions by Inducing Apoptosis in Human Glioblastoma U87MG Cells. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A new spin on electrochemistry in the undergraduate lab (2021)

Abstract The growing interest in electrochemistry over recent years has sparked an increase in the popularity of various electrochemical techniques, including more advanced methods, that have previously been overlooked in academia and industry. This makes comprehensive hands-on experience in electrochemistry a highly demanded addition to chemistry graduates. However, many students do not receive sufficient training in the theory and experimental design to confidently use and apply various electrochemical techniques throughout their undergraduate, and sometimes even in graduate studies. Here we summarize the theory and practical applications for both rotating disk electrode (RDE) and rotating ring disk electrode (RRDE) techniques. The different modes of operation of rotating ring disk voltammetry, methodologies of data analysis and interpretation as well as the scope of the information that can be extracted from the RDE/RRDE are discussed. Proposed modifications of the laboratory curriculum will allow students to examine and learn valuable information about the reactions on the surface of the electrode/liquid interface. This information will allow chemists to confidently use RDE and RRDE techniques for a wide range of research and development targets. Furthermore, incorporating these techniques into existing chemistry laboratories will help chemistry educators to enrich the undergraduate chemistry curriculum and improve students’ learning outcomes.
In-situheight engineering of InGaAs / GaAs quantum dots by chemical beam epitaxy (2016)

This special section of the Journal of Nanophotonics is focused on optics, spectroscopy, and nanophotonics of quantum dots.
Interactions of Stabilizers with Proteins During Freezing and Drying (1994)

During the course of processing, shipping and storage, proteins are often subjected to either freezing or drying stress, or both. The preservation of proteins during freezing and drying is fundamentally different for each process. Protection of labile proteins during freezing appears to be due to the same thermodynamic mechanism that accounts for solute-induced stabilization in nonfrozen aqueous solution. Namely, preferential exclusion of the solute leads to stabilization of the native state of the protein. Protection of proteins during drying by sugars is due to the sugar hydrogen bonding to the dried protein and serving as a water replacement. Recovery of enzyme activity after freeze-drying and rehydration correlates directly with the maintenance of the native protein structure in the dried state. Sugars protect labile proteins by inhibiting lyophilization-induced unfolding. Finally, certain polymers (e.g., polyvinylpyrrolidone) protect freeze-dried multimeric enzymes during freeze-drying and rehydration. These compounds cannot serve as "water replacements" in the dried state. Rather they inhibit the freezing- and drying- induced dissociation. The fully polymerized oligomers are more resistant to these stresses.
Integration Site-Specific Transcriptional Reporter Gene Analysis Using Flp Recombinase Targeted Cell Lines (2007)

While high-throughput genome-wide approaches are useful to identify important regulatory regions, traditional reporter gene methodologies still represent the ultimate steps in fine structure analysis of transcriptional control elements. However, there are still several inherent limitations in the currently available transient and stable transfection systems often leading to aberrant function of specific cis elements. In this study we overcome these problems and have developed a novel and widely applicable system that permits the comparison of transcriptional reporter gene activities following site-specific genomic integration. By using Flp recombinase-mediated integration, the system allows the integration and expression of a series of reporter gene constructs at exactly the same genomic location and orientation in all cells of any one culture. The resulting reporter gene lines carry a single reporter gene, which is incorporated within a measurably active chromatinized setting, thus more closely reflecting the endogenous gene environment.
Surface Energy as a Barrier to Creasing of Elastomer Films: An Elastic Analogy to Classical Nucleation (2012)

In a soft elastic film compressed on a stiff substrate, creases nucleate at preexisting defects and grow across the surface of the film like channels. Both nucleation and growth are resisted by the surface energy, which we demonstrate by studying creases for elastomers immersed in several environments--air, water, and an aqueous surfactant solution. Measurement of the position where crease channeling is arrested on a gradient thickness film provides a uniquely characterized strain that quantitatively reveals the influence of surface energy, unlike the strain for nucleation, which is highly variable due to the sensitivity to defects. We find that these experimental data agree well with the prediction of a scaling analysis.
Current medical diagnosis & treatment (2009)

Current: Medical Diagnosis & Treatment , Current: Medical Diagnosis & Treatment , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid (2013)

Core-shell conjugated polymer nanoparticles (CPNs) were fabricated by complexing a semi-flexible, primary amine-containing conjugated polymer (CP) with hyaluronic acid (HA). Flexibility introduced in the rigid rod conjugated backbone allows backbone reorganization to increase π-π interaction under ionic complexation, resulting in core-shell nanoparticles with a hydrophobic CP core wrapped with a HA shell. The core-shell nanoparticles exhibited no cellular toxicity and high cancer cell specificity with minimal binding to normal cells.
Nanoscale studies of segregation at coherent heterophase interfaces in α‐Fe based systems (2004)

Abstract Heterophase interfaces are characterized with respect to atomic‐scale local compositions in two α‐Fe‐based alloy systems by three‐dimensional atom probe microscopy. The proximity histogram method is utilized for determining the compositions of the precipitates, the matrix phase and the Gibbsian interfacial excess of solute. Suitable methods to measure segregation in multicomponent systems at heterophase interfaces independent of the position of the dividing interface are discussed. Very little Sb segregates to the heterophase interface between coherent plate‐shaped moybdenum nitride precipitates, which are &lt;1 nm thick, and the α‐Fe matrix: the relative interfacial excess of Sb is only 0.12 ± 0.1 nm −2 . This is in sharp contrast to the interfacial excess of 7 ± 3 nm −2 for molybdenum nitride plates that have grown to 2–10 nm thick (or 20–30 nm in diameter for spheroidal precipitates) with a semicoherent interface with misfit dislocations, as reported earlier. Small coherent Cu‐rich precipitates with a metastable bcc structure in an α‐Fe matrix exhibit interfacial segregation of Ni and Mn at their interfaces with excesses of 1.47 ± 0.43 and 0.95 ± 0.31 nm −2 , respectively. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis (2005)

Debulking hepatic resections do not appear to offer any advantage in the treatment of patients with alveolar echinococcosis.
Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation (2005)

We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown alga), against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Phloroglucinol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H(2)O(2)), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, phloroglucinol reduced H(2)O(2) induced apoptotic cells formation in V79-4 cells. In addition, phloroglucinol inhibited cell damage induced by serum starvation and radiation through scavenging ROS. Phloroglucinol increased the catalase activity and its protein expression. In addition, catalase inhibitor abolished the protective effect of phloroglucinol from H(2)O(2) induced cell damage. Furthermore, phloroglucinol increased phosphorylation of extracellular signal regulated kinase (ERK). Taken together, the results suggest that phloroglucinol protects V79-4 cells against oxidative damage by enhancing the cellular catalase activity and modulating ERK signal pathway.
[Targeted chemotherapy of hepatocellular carcinoma with SMANCS/Lipiodol--how to use SMANCS/Lipiodol]. (1998)

The first drug only for arterial injection, SMANCS/Lipiodol, which offers targeted chemotherapy for hepatocellular carcinoma (HCC), now commercially available. Based on our experience using SMANCS/Lipiodol for 424 patients with HCC, the golden standard of how to use SMANCS/Lipiodol for complete necrosis of tumor was described. The initial dose of SMANCS/Lipiodol was varied 2 to 6 mg per body, mainly depending on the size of the tumor. All feeding arteries of HCC have to be verified on angiogram, and the drug must be injected via an adequate artery. Sometimes, a tumor changes its feeding arteries. Additional administrations with an interval of one month were done till the entire tumor was filled with SMANCS/Lipiodol (grade 4). One or two months after achievement of grade 4, we must examine how much drug was removed from tumor on CT. If the entire tumor is not filled with the drug, further injections are recommended to maintain grade 4. Almost all tumors shrank in 3 to 4 months while maintaining grade 4. Frequent administration of low doses (1-3 mg per body) is recommended. Discontinvation of administration was done on the following findings; tumor size reduction of over 90% or complete disappearance of tumor stain. With arterial injection therapy of SMANCS/Lipiodol, survival of patients with unresectable HCC was prolonged, especially in 272 patients who were good candidates for therapy. (Those with Child C liver cirrhosis, with a tumor occupying all four segments of the liver, and/or with extrahepatic spread at initial arterial injection of the drug were excluded.) The 1, 2, 5, and 10 year survival rates were 83%, 58%, 34%, and 25%, respectively.
Progress in the application of notch asymptotics to the understanding of complete contacts subject to fretting fatigue (2012)

ABSTRACT This paper describes progress in the interpretation of notch fatigue data by re‐working the Williams solution to bring out the effects of mode mixity and the limits of small scale yielding. The results are displayed in K I versus K II space. Experimental results from complete fretting fatigue tests using a high strength steel alloy known as “super CMV” are then plotted out on this diagram and it is shown that the fretting damage does not significantly reduce fatigue life, while the stress localisation effects of adhered pad edges does.
An Implementation and Evaluation of the AMLS Method for Sparse Eigenvalue Problems (2008)

We describe an efficient implementation and present a performance study of an automated multi-level substructuring (AMLS) method for sparse eigenvalue problems. We assess the time and memory requirements associated with the key steps of the algorithm, and compare it with the shift-and-invert Lanczos algorithm. Our eigenvalue problems come from two very different application areas: accelerator cavity design and normal-mode vibrational analysis of polyethylene particles. We show that the AMLS method, when implemented carefully, outperforms the traditional method in broad application areas when large numbers of eigenvalues are sought, with relatively low accuracy.
Boomerang Connectivity Table: A New Cryptanalysis Tool. (2018)

A boomerang attack is a cryptanalysis framework that regards a block cipher E as the composition of two sub-ciphers \(E_1\circ E_0\) and builds a particular characteristic for E with probability \(p^2q^2\) by combining differential characteristics for \(E_0\) and \(E_1\) with probability p and q, respectively. Crucially the validity of this figure is under the assumption that the characteristics for \(E_0\) and \(E_1\) can be chosen independently. Indeed, Murphy has shown that independently chosen characteristics may turn out to be incompatible. On the other hand, several researchers observed that the probability can be improved to p or q around the boundary between \(E_0\) and \(E_1\) by considering a positive dependency of the two characteristics, e.g. the ladder switch and S-box switch by Biryukov and Khovratovich. This phenomenon was later formalised by Dunkelman et al. as a sandwich attack that regards E as \(E_1\circ E_m \circ E_0\), where \(E_m\) satisfies some differential propagation among four texts with probability r, and the entire probability is \(p^2q^2r\). In this paper, we revisit the issue of dependency of two characteristics in \(E_m\), and propose a new tool called Boomerang Connectivity Table (BCT), which evaluates r in a systematic and easy-to-understand way when \(E_m\) is composed of a single S-box layer. With the BCT, previous observations on the S-box including the incompatibility, the ladder switch and the S-box switch are represented in a unified manner. Moreover, the BCT can detect a new switching effect, which shows that the probability around the boundary may be even higher than p or q. To illustrate the power of the BCT-based analysis, we improve boomerang attacks against Deoxys-BC, and disclose the mechanism behind an unsolved probability amplification for generating a quartet in SKINNY. Lastly, we discuss the issue of searching for S-boxes having good BCT and extending the analysis to modular addition.
Mutations in MYB3R1 and MYB3R4 Cause Pleiotropic Developmental Defects and Preferential Down-Regulation of Multiple G2/M-Specific Genes in Arabidopsis (2011)

R1R2R3-Myb proteins represent an evolutionarily conserved class of Myb family proteins important for cell cycle regulation and differentiation in eukaryotic cells. In plants, this class of Myb proteins are believed to regulate the transcription of G2/M phase-specific genes by binding to common cis-elements, called mitosis-specific activator (MSA) elements. In Arabidopsis (Arabidopsis thaliana), MYB3R1 and MYB3R4 act as transcriptional activators and positively regulate cytokinesis by activating the transcription of KNOLLE, which encodes a cytokinesis-specific syntaxin. Here, we show that the double mutation myb3r1 myb3r4 causes pleiotropic developmental defects, some of which are due to deficiency of KNOLLE whereas other are not, suggesting that multiple target genes are involved. Consistently, microarray analysis of the double mutant revealed altered expression of many genes, among which G2/M-specific genes showed significant overrepresentation of the MSA motif and a strong tendency to be down-regulated by the double mutation. Our results demonstrate, on a genome-wide level, the importance of the MYB3R-MSA pathway for regulating G2/M-specific transcription. In addition, MYB3R1 and MYB3R4 may have diverse roles during plant development by regulating G2/M-specific genes with various functions as well as genes possibly unrelated to the cell cycle.
Organic solar cells on indium tin oxide and aluminum doped zinc oxide anodes (2007)

The authors compare organic solar cells using two different transparent conductive oxides as anode: indium tin oxide (ITO) and three kinds of aluminum doped zinc oxide (ZAO). These anodes with different work functions are used for small molecule photovoltaic devices based on an oligothiophene derivative as donor and fullerene C60 as acceptor molecule. It turns out that cells on ITO and ZAO have virtually identical properties. In particular, the authors demonstrate that the work function of the anode does not influence the Voc of the photovoltaic device due to the use of doped transport layers.
Online resources (2009)

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Adrenal function in Smith–Lemli–Opitz syndrome (2011)

Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation syndrome due to mutations of the 7-dehydrocholesterol reductase gene (DHCR7), which leads to a deficiency of cholesterol synthesis and an accumulation of 7-dehydrocholesterol. The SLOS clinical spectrum ranges from multiple major malformations to a mild phenotype with minor anomalies and intellectual disability. Several children with SLOS and adrenal insufficiency have been described. We performed ovine corticotropin (oCRH) testing in 35 SLOS patients and 16 age- and gender-matched controls. We reviewed prior adrenocorticotropin (ACTH) stimulation tests of our SLOS patients (19 of 35 available) and reviewed results of ACTH stimulation tests from 10 additional SLOS patients. Results from oCRH testing showed that patients with SLOS had significantly higher ACTH baseline values than healthy controls (24.8 ± 15.3 pg/ml vs. 17.8 ± 7.5 pg/ml, P = 0.034). However, no statistically significant differences were noted for peak ACTH values (74.4 ± 35.0 pg/ml vs. 64.0 ± 24.9 pg/ml, P = 0.303) and for baseline (14.2 ± 7.8 mcg/dl vs. 14.2 ± 6.3 mcg/dl, P = 0.992) and peak cortisol values (28.2 ± 7.9 mcg/dl vs. 24.8 ± 8.1 mcg/dl, P = 0.156). The area-under-the-curve (AUC) was not significantly different in SLOS patients compared to controls for both ACTH (250.1 ± 118.7 pg/ml vs. 195.3 ± 96.6 pg/ml, P = 0.121) as well as cortisol secretion (83.1 ± 26.1 mcg/dl vs. 77.8 ± 25.9 mcg/dl, P = 0.499). ACTH stimulation test results were normal in 28 of 29 tests. The individual with the abnormal test results had subsequent normal oCRH tests. The slightly increased baseline ACTH level seen during oCRH testing may be due to compensated adrenocortical insufficiency. However, we were able to show that our patients with SLOS had an adequate glucocorticoid response, and thus, in mild to moderate cases of SLOS stress steroid coverage may not be warranted.
LOCALIZATION OF HIPPOCAMPAL ATROPHY IN ALZHEIMER'S DISEASE (2011)

International audience
Medium access control feedback mechanism for uplink resource management in wireless TDMA packet data systems (2003)

The shared channel feedback (SCF) procedures and fields as specified in IS-136 DCCH are not well-suited for long packet data transactions and do not facilitate flexible sharing of resources among users. We describe a simple and robust packet channel feedback (PCF) mechanism for an IS-136 based TDMA packet data channel (PDCH) by identifying the minimal set of functions and fields required to manage both contention access and reserved access. The proposed scheme has fewer error conditions, unambiguous state transitions and better performance under error conditions. The PCF scheme provides considerable flexibility in assigning bandwidth to multiple users and allows the efficient management of contention, reservation and scheduling on each sub-channel without wasted slots.