gebhart/patrepeval huggingface dataset:
Proteomic Analysis of Protease Resistant Proteins in the Diabetic Rat Kidney (2012)

Glycation induced protein aggregation has been implicated in the development of diabetic complications and neurodegenerative diseases. These aggregates are known to be resistant to proteolytic digestion. Here we report the identification of protease resistant proteins from the streptozotocin induced diabetic rat kidney, which included enzymes in glucose metabolism and stress response proteins. These protease resistant proteins were characterized to be advanced glycation end products modified and ubiquitinated by immunological and mass spectrometry analysis. Further, diabetic rat kidney exhibited significantly impaired proteasomal activity. The functional analysis of identified physiologically important enzymes showed that their activity was reduced in diabetic condition. Loss of functional activity of these proteins was compensated by enhanced gene expression. Aggregation prone regions were predicted by in silico analysis and compared with advanced glycation end products modification sites. These findings suggested that the accumulation of protein aggregates is an inevitable consequence of impaired proteasomal activity and protease resistance due to advanced glycation end products modification.
Group velocity, phase velocity, and dispersion in human calcaneusin vivo (2007)

Commercial bone sonometers measure broadband ultrasonic attenuation and/or speed of sound (SOS) in order to assess bone status. Phase velocity, which is usually measured in frequency domain, is a fundamental material property of bone that is related to SOS, which is usually measured in time domain. Four previous in vitro studies indicate that phase velocity in human cancellous bone decreases with frequency (i.e., negative dispersion). In order to investigate frequency-dependent phase velocity in vivo, through-transmission measurements were performed in 73 women using a GE Lunar Achilles Insight commercial bone sonometer. Average phase velocity at 500 kHz was 1489 +/- 55 m/s (mean +/- standard deviation). Average dispersion rate was -59 +/- 52 m/sMHz. Group velocity was usually lower than phase velocity, as is expected for negatively dispersive media. Using a stratified model to represent cancellous bone, the reductions in phase velocity and dispersion rate in vivo as opposed to in vitro can be explained by (1) the presence of marrow instead of water as a fluid filler, and (2) the decreased porosity of bones of living (compared with deceased) subjects.
Methods and limitations of security policy reconciliation (2006)

A security policy specifies session participant requirements. However, existing frameworks provide limited facilities for the automated reconciliation of participant policies. This paper considers the limits and methods of reconciliation in a general-purpose policy model. We identify an algorithm for efficient two-policy reconciliation and show that, in the worst-case, reconciliation of three or more policies is intractable. Further, we suggest efficient heuristics for the detection and resolution of intractable reconciliation. Based upon the policy model, we describe the design and implementation of the Ismene policy language. The expressiveness of Ismene, and indirectly of our model, is demonstrated through the representation and exposition of policies supported by existing policy languages. We conclude with brief notes on the integration and enforcement of Ismene policy within the Antigone communication system.
Nucleotide sequence ofnifKand partial sequence ofnifDfromFrankiaspecies strain FaCl (1988)

We have previously reported the cloning of the nifD and nifK genes from Frankia (1) that encode the a-and 5-subunits of dinitrogenase, respectively. Here we present the complete
Identification of Historical Veziragasi Aqueduct Using the Operational Modal Analysis (2014)

This paper describes the results of a model updating study conducted on a historical aqueduct, called Veziragasi, in Turkey. The output-only modal identification results obtained from ambient vibration measurements of the structure were used to update a finite element model of the structure. For the purposes of developing a solid model of the structure, the dimensions of the structure, defects, and material degradations in the structure were determined in detail by making a measurement survey. For evaluation of the material properties of the structure, nondestructive and destructive testing methods were applied. The modal analysis of the structure was calculated by FEM. Then, a nondestructive dynamic test as well as operational modal analysis was carried out and dynamic properties were extracted. The natural frequencies and corresponding mode shapes were determined from both theoretical and experimental modal analyses and compared with each other. A good harmony was attained between mode shapes, but there were some differences between natural frequencies. The sources of the differences were introduced and the FEM model was updated by changing material parameters and boundary conditions. Finally, the real analytical model of the aqueduct was put forward and the results were discussed.
Biologically Active Novel Conformational State of Botulinum, the Most Poisonous Poison (2005)

Botulinum neurotoxins (serotypes A-G), the most toxic substances known to humankind, cause flaccid muscle paralysis by blocking acetylcholine release at nerve-muscle junctions through a very specific and exclusive endopeptidase activity against SNARE proteins of presynaptic exocytosis machinery. We have examined polypeptide folding of the endopeptidase moiety of botulinum neurotoxin/A (the light chain) under conditions of its optimal enzymatic activity and have found that one of its stable conformational states is a molten-globule, which retains over 60% of its optimal enzyme activity. More importantly, we have discovered that the light chain acquires a novel pre-imminent molten-globule enzyme conformation at the physiologically relevant temperature, 37 degrees C. The pre-imminent molten-globule enzyme form also exhibited the maximum endopeptidase activity against its intracellular substrate, SNAP-25 (synaptosomal associated protein of 25 kDa). These findings will not only open new avenues to design effective diagnostics and antidotes against botulism but also provide new information on enzymatically active molten-globule or molten-globule like structures.
A new EUVE-detected flare star (EUVE J0613-23.9B) (2003)

Extreme Ultraviolet Explorer (EUVE) observations have provided detailed spectroscopic and timing studies of several flare stars, including AU Mic (Cully et al., 1993), AD Leo (Hawley et al., 1995) and EQ Peg (Monsignori-Fossi et al., 1995).&#13;\n In this bulletin, we present the EUVE and optical follow-up observations of a newly detected flare star. This star was serendipitously discovered during an EUVE observation of the G star HD 43162 as part of the analysis for the 3rd EUVE Right Angle Program Catalog (Christian, 2002). Analysis of the EUVE spectra obtained during the largest flare (Fe XIX-XXIV emission and a strong 300-650 Å continuum) have been presented elsewhere (Christian et al., 2003). We present optical spectroscopy and results obtained at MT Stromlo Observatory to identify the optical counterpart in § 1, and the long-term EUVE Deep Survey light-curves in § 2.
Opportunistic network coding for video streaming over wireless (2007)

In this paper, we study video streaming over wireless networks with network coding capabilities. We build upon recent work, which demonstrated that network coding can increase throughput over a broadcast medium, by mixing packets from different flows into a single packet, thus increasing the information content per transmission. Our key insight is that, when the transmitted flows are video streams, network codes should be selected so as to maximize not only the network throughput but also the video quality. We propose video-aware opportunistic network coding schemes that take into account both aspects, namely (i) the decodability of network codes by several receivers and (ii) the distortion values and playout deadlines of video packets. Simulation results show that our schemes significantly improve both video quality and throughput.
DS/CDMA with in-cell spreading sequence reuse and iterative multistage detection (2002)

We introduce a code-division multiple access (CDMA) concept which makes it possible to accommodate a higher number of users than the spreading factor N. The idea is to assign orthogonal spreading sequences, overlaid with a pseudo-noise (PN) sequence, to the first N users, and to reuse these orthogonal spreading sequences, but overlaying them with another PN sequence for all additional users. The proposed technique can thus accommodate N users without any mutual interference and a number of additional users at the expense of some signal-to-noise ratio (SNR) penalty. This represents a significant capacity increase with respect to presently available multiple access techniques. When the total number of users is larger than N, detection is performed in two separate steps, one for the first N users and one for the set of additional users. Furthermore, the process is iterated two or more times to obtain more reliable receiver decisions.
New Capabilities for the TEM: Automatic Orientation Measurement and Nanocrystal Grain Maps (1999)

Abstract Orientation Imaging Microscopy (OIM) is a rapid and spatially specific technique for automatically measuring individual crystallographic orientations in a polycrystalline sample. The technique is based on electron backscatter diffraction in the scanning electron microscope (SEM). While the OIM technique has seen many applications to the investigation of structure/ property relationships in polycrystalline materials, with grain sizes ranging from millimeters to submicron, it is not easily applied to the characterization of microstructures at the nanometer scale due to the inherent resolution limitations of the SEM. Thus, a complementary technique for the transmission electron microscope (TEM) would be advantageous for the study of local orientation in submicron structures such as those that exist in nanocrystalline materials and deformed materials.
Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program (2017)

Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase Gata2 expression in hematopoietic stem/progenitor cells and control hematopoiesis. The +9.5-kb enhancer activates transcription in endothelium and hematopoietic stem cells (HSCs), and its deletion abrogates HSC generation. The -77-kb enhancer activates transcription in myeloid progenitors, and its deletion impairs differentiation. Since +9.5<sup>-/-</sup> embryos are HSC deficient, it was unclear whether the +9.5 functions in progenitors or if GATA-2 expression in progenitors solely requires -77. We further dissected the mechanisms using -77;+9.5 compound heterozygous (CH) mice. The embryonic lethal CH mutation depleted megakaryocyte-erythrocyte progenitors (MEPs). While the +9.5 suffices for HSC generation, the -77 and +9.5 must reside on one allele to induce MEPs. The -77 generated burst-forming unit-erythroid through the induction of GATA-1 and other GATA-2 targets. The enhancer circuits controlled signaling pathways that orchestrate a GATA factor-dependent blood development program.
Electrochemically Switchable Cucurbit[7]uril-Based Pseudorotaxanes (2006)

[Structure: see text] The binding location of cucurbit[7]uril can be controlled via redox conversions in these novel, structurally simple pseudorotaxanes.
An Improved CQA Quantization Algorithm for Physical Layer Secret Key Extraction (2020)

With the wide application of wireless sensor network, the security mechanism based on cryptography faces many challenges in computational complexity and security, and physical layer secret key extraction as an alternative solution has been widely studied. To meet the requirements of high key generation rate (KGR) and low key disagreement rate (KDR) in the secret key extraction process, an improved channel quantization alternating (CQA) algorithm is proposed in this paper. The algorithm filtrates the phase values of channel frequency response (CFR) using test results of CFR amplitude values, and then quantizes the reserved phase values by CQA algorithm. Compared to the existing CQA algorithm and improved channel quantization with guard-band (CQG) algorithm, simulation results show that the KDR of the proposed algorithm decreases by 31.5% and 20.4%, and the KGR decreases by 5.4% and increases by 5.2%, respectively. The proposed algorithm improves the KGR while ensuring a low KDR, and the extracted secret key passes the NIST test.
What Is Your Diagnosis? (2005)

A 5-year-old neutered male Golden Retriever was evaluated because of lameness of the right forelimb of approximately 2 months' duration. Radiography of the right shoulder joint and forelimb revealed mild degenerative joint disease of the right elbow joint. The only abnormality detected on serum biochemical analyses was a high cholesterol concentration (420 mg/dL; reference range, 114 to 330 mg/dL). The dog had been treated with aspirin, carprofen, an intra-articular injection of methylprednisolone administered into the right shoulder joint, polysulfated glycosaminoglycans, and doxycycline with no improvement in the lameness.
Refined analysis of RGHWs of code pairs coming from Garcia-Stichtenoth's second tower (2015)

Asymptotically good sequences of ramp secret sharing schemes were given in [Asymptotically good ramp secret sharing schemes, arXiv:1502.05507] by using one-point algebraic geometric codes defined from asymptotically good towers of function fields. Their security is given by the relative generalized Hamming weights of the corresponding codes. In this paper we demonstrate how to obtain refined information on the RGHWs when the codimension of the codes is small. For general codimension, we give an improved estimate for the highest RGHW.
Quantum Error Correction (2006)

A mathematical model of computation is an idealized abstraction. We design algorithms and perform analysis on the assumption that the mathematical operations we specify will be carried out exactly, and without error. Physical devices that implement an abstract model of computation are imperfect and of limited precision. For example, when a digital circuit is implemented on a physical circuit board, unwanted electrical noise in the environment may cause components to behave differently than expected, and may cause voltage levels (bit-values) to change. These sources of error must be controlled or compensated for, or else the resulting loss of efficiency may reduce the power of the information-processing device. If individual steps in a computation succeed with probability p, then a computation involving t sequential steps will have a success probability that decreases exponentially as pt. Although it may be impossible to eliminate the sources of errors, we can devise schemes to allow us to recover from errors using a reasonable amount of additional resources. Many classical digital computing devices use error-correcting codes to perform detection of and recovery from errors. The theory of error-correcting codes is itself a mathematical abstraction, but it is one that explicitly accounts for errors introduced by the imperfection and imprecision of realistic devices. This theory has proven extremely effective in allowing engineers to build computing devices that are resilient against errors. Quantum computers are more susceptible to errors than classical digital computers, because quantum mechanical systems are more delicate and more difficult to control. If large-scale quantum computers are to be possible, a theory of quantum error correction is needed. The discovery of quantum error correction has given researchers confidence that realistic large-scale quantum computing devices can be built despite the presence of errors. We begin by considering fundamental concepts for error correction in a classical setting. We will focus on three of these concepts: (a) the characterization of the error model, (b) the introduction of redundancy through encoding, and (c) an error recovery procedure. We will later see that these concepts generalize quite naturally for quantum error correction.
HYPROMELLOSE - A CHOICE OF POLYMER IN EXTENDED RELEASE TABLET FORMULATION (2014)

Hydroxypropylmethylcellulose (HPMC) also know as hypromellose, is largely in used cellulose ether in the development of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. This review provides a current insight into hypromellose and its applicability to hydrophilic matrices in order to highlight the basic parameters that affect its performance. Topics covered include the chemical, thermal and mechanical properties of hypromellose, hydration of the polymer matrices, the mechanism of drug release and the various models used to predict the kinetics and mechanism of drug release from the HPMC matrices. This review also provides the maximum potency of hypromellose used in various dosage form and current patent status review of hypromellose as a release controlling polymer in extended release matrix systems.
High-density polyethylene material versus autogenous grafts in craniofacial augmentation procedures (2019)

From the present study, it can be concluded that porous HDPE implants are an effective alternative to autogenous grafts in accordance of overall acceptance for correction of residual facial deformity when proper case selection, exclusion of negative prognostic factors, and meticulous surgical procedure are followed.
Tenderness Improvement of the Major Muscles of the Beef Carcass by Electrical Stimulation (1981)

ABSTRACT Steaks (arm; blade; seven‐bone; rib, small‐end; top loin; tenderloin; top sirloin; tip, cap‐off; and round) from electrically stimulated (ES) and control sides of 20 beef carcasses were cut and frozen at 5 days postmortem. Forequarter muscles that were improved by ES were the longissimus dorsi (rib steak), the subscapularis and supraspinatus (blade steak), and the superficial pectoral (arm steak). Hindquarter muscles that were improved by ES were the longissimus dorsi (top loin steak), the biceps femoris and gluteus medius (top sirloin steak), and the semimembranosus and biceps femoris (round steak). ES, in addition to improving tenderness of the longissimus dorsi, increased tenderness of other major muscles in the carcass.
Why Should Dialysis Benefit Schizophrenia? (1979)

If dialysis is successful for the treatment of schizophrenia, the artificial kidney must be removing something which the human kidney cannot, unless other nonspecific factors are involved. Either there is an abnormal compound present which is retained by normal renal tubular transport processes, or the kidney of a schizophrenic must be abnormal in that it fails to excrete a normally present compound. Since the latter explanation is less probable, biochemical research should focus on classes of compounds which are known to be handled differently by the artificial kidney than by the human kidney. A dialyzable "schizophrenic toxin" might be a nonprotein, nonprotein-bound of molecular weight below 500 daltons such as an organic acid or base. Proteins, peptides, amino acids, and trace elements are less likely possibilities.
Diagnostic surgical pathology on CD-ROM (1999)

The Third Edition of the standard-setting reference, Diagnostic Surgical Pathology, is available on a fully searchable CD-ROM. The disk fits into a pocket and contains the full text and illustrations of this encyclopedic two-volume work - 2,784 pages of text and over 3,700 illustrations, including 3,421 full-color photographs. The program's multiple search functions and the extensive hypertext links allow users to instantly access the text, illustrations, and references they need. Key references in each chapter are also linked to MEDLINE[registered] abstracts through a 'one-click' online connection. It is Windows or Macintosh compatible. This CD-ROM can be purchased separately, or at a special price by ordering the two-volume text plus the CD-ROM.
Anatomic is better than isometric posterior cruciate ligament tunnel placement based upon in vivo simulation (2018)

IV.
Research design for evaluation of finger input properties on multi-touch screen (2011)

Interactive tabletop display provides a collaborative workspace to users around a table. Users sit in front of each other and they perform direct and collaborative multi-touch interaction simultaneously. Users access the interactive elements using their bare fingers. The finger works as a pointer device, and it has direct relation with the size, shape, and configuration of the interactive elements on sensitive displays. It is found that there is lack of precise selection of small size interactive elements owing to users' fat fingers. In this regard, it is aimed to propose a research design to evaluate the finger input properties in the context of imprecise selection. However, proposed research design consists of various phases that help to carry out the different research activities to evaluate finger input properties accordingly. It assists in investigating the factors that may cause the imprecise selection in the direct multi-touch input.
Supplementary Figure 2 from Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase (2023)

Supplementary Figure 2 from Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
Detecting the road surface condition by using mobile crowdsensing with drive recorder (2017)

Road surface conditions affect transport safety and driving comfort, particularly in snowy areas. This paper proposes a new method for detecting road surface conditions based on crowdsourced mobile sensing technology. The method can efficiently detect road surface conditions using motion sensors embedded in smartphones mounted on vehicles. Detecting road conditions using such sensors, which are usually loosely placed in the vehicle, nonetheless poses a challenge. Our approach comprises two modules: a clustering module and classification module. The clustering module uses a K-means algorithm to distribute the vehicle travel mode into a proper cluster. The classification module uses the random forest classifier, which is assigned to each group of vehicle travel mode, to classify the road surface conditions. We defined new road surface conditions as the estimation target, considering both the substance that covers the road surface and the shape of the road surface itself. The results show that our approach can detect road surface conditions with accuracy as high as 90%.
Strategic planning for data warehousing in the public sector (1996)

The City of St. Louis, Missouri, is a large municipality with an extremely fragmented organizational structure. The City recently undertook a major strategic planning study for development of its municipal information systems. In the course of the study, data warehousing emerged as a strategy for consolidating and sharing information among many City departments with different informational needs and a variety of computing platforms. We describe processes and analytical methods that proved useful for shaping a data warehousing strategy and for determining the contents of the data warehouse. We also present some cautionary conclusions about the development of monolithic data warehouses for decision support.