gebhart/patrepeval huggingface dataset:
Sex-related differences in chromatic sensitivity (2008)

Generally women are believed to be more discriminating than men in the use of color names and this is often taken to imply superior color vision. However, if both X-chromosome linked color deficient males (8%) and females (<1%) as well as heterozygote female carriers (15%) are excluded from comparisons, then differences between men and women in red-green (RG) color discrimination have been reported as not being significant (e.g., Pickford, 1944; Hood et al., 2006). We re-examined this question by assessing the performance of 150 males and 150 females on the color assessment and diagnosis (CAD) test (Rodriguez-Carmona et al., 2005). This is a sensitive test that yields small color detection thresholds. The test employs direction-specific, moving, chromatic stimuli embedded in a background of random, dynamic, luminance contrast noise. A four-alternative, forced-choice procedure is employed to measure the subject's thresholds for detection of color signals in 16 directions in color space, while ensuring that the subject cannot make use of any residual luminance contrast signals. In addition, we measured the Rayleigh anomaloscope matches in a subgroup of 111 males and 114 females. All the age-matched males (30.8 +/- 9.7) and females (26.7 +/- 8.8) had normal color vision as diagnosed by a battery of conventional color vision tests. Females with known color deficient relatives were excluded from the study. Comparisons between the male and female groups revealed no significant differences in anomaloscope midpoints (p = 0.709), but a significant difference in matching ranges (p = 0.040); females on average tended to have a larger mean range (4.11) than males (3.75). Females also had significantly higher CAD thresholds than males along the RG (p = 0.0004), but not along the yellow-blue (YB) discrimination axis. The differences between males and females in RG discrimination may be related to the heterozygosity in X-linked cone photo pigment expression common among females.
The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation (2020)

Several adaptor molecules bind to cytoplasmic tails of β-integrins and facilitate bidirectional signaling, which is critical in thrombosis and hemostasis. Interfering with integrin-adaptor interactions spatially or temporally to inhibit thrombosis without affecting hemostasis is an attractive strategy for the development of safe antithrombotic drugs. We show for the first time that the 14-3-3ζ-c-Src-integrin-β3 complex is formed during platelet activation. 14-3-3ζ-c-Src interaction is mediated by the -PIRLGLALNFSVFYYE- fragment (PE16) on the 14-3-3ζ and SH2-domain on c-Src, whereas the 14-3-3ζ-integrin-β3 interaction is mediated by the -ESKVFYLKMKGDYYRYL- fragment (EL17) on the 14-3-3ζ and -KEATSTF- fragment (KF7) on the β3-integrin cytoplasmic tail. The EL17-motif inhibitor, or KF7 peptide, interferes with the formation of the 14-3-3ζ-c-Src-integrin-β3 complex and selectively inhibits β3 outside-in signaling without affecting the integrin-fibrinogen interaction, which suppresses thrombosis without causing significant bleeding. This study characterized a previously unidentified 14-3-3ζ-c-Src-integrin-β3 complex in platelets and provided a novel strategy for the development of safe and effective antithrombotic treatments.
Characterization of N-Glycans from Arabidopsis. Application to a Fucose-Deficient Mutant1 (1999)

The structures of glycans N-linked to Arabidopsis proteins have been fully identified. From immuno- and affinodetections on blots, chromatography, nuclear magnetic resonance, and glycosidase sequencing data, we show that Arabidopsis proteins are N-glycosylated by high-mannose-type N-glycans from Man5GlcNAc2 to Man9GlcNAc2, and by xylose- and fucose (Fuc)-containing oligosaccharides. However, complex biantenary structures containing the terminal Lewis a epitope recently reported in the literature (A. -C. Fitchette-Lainé, V. Gomord, M. Cabanes, J.-C. Michalski, M. Saint Macary, B. Foucher, B. Cavalier, C. Hawes, P. Lerouge, and L. Faye [1997] Plant J 12: 1411-1417) were not detected. A similar study was done on the Arabidopsis mur1 mutant, which is affected in the biosynthesis of L-Fuc. In this mutant, one-third of the Fuc residues of the xyloglucan has been reported to be replaced by L-galactose (Gal) (E. Zablackis, W.S. York, M. Pauly, S. Hantus, W.D. Reiter, C.C.S. Chapple, P. Albersheim, and A. Darvill [1996] Science 272: 1808-1810). N-linked glycans from the mutant were identified and their structures were compared with those isolated from the wild-type plants. In about 95% of all N-linked glycans from the mur1 plant, L-Fuc residues were absent and were not replaced by another monosaccharide. However, in the remaining 5%, L-Fuc was found to be replaced by a hexose residue. From nuclear magnetic resonance and mass spectrometry data of the mur1 N-glycans, and by analogy with data reported on mur1 xyloglucan, this subpopulation of N-linked glycans was proposed to be L-Gal-containing N-glycans resulting from the replacement of L-Fuc by L-Gal.
Evaluation of Ion Exchange Resins for Removal of Inhibitory Compounds from Corn Stover Hydrolyzate for Xylitol Fermentation (2003)

The use of dilute acids to catalyze the hydrolysis of hemicellulose to its sugar constituents is well-known and effective. However, a major problem associated with this pretreatment is the poor fermentability of the produced hydrolyzate as a result of the presence of the microorganism's inhibitory compounds. In the present work, seven ion-exchange resins were tested in order to detoxify corn stover hydrolyzate. Regarding xylose recovery, it was observed that more than 92% recovery was feasible. Furfural removal varied from 53.% to 99.%, and hydroxymethylfurfural (HMF) removal was effective between 37% and 100%. Acetic acid was totally removed by Purolite A 103 S resin. Corn stover hydrolyzate (CSH) treated with Purolite A 103 S, and Finex CS 14 GC resins, was tested as substrate for xylitol production using a yeast, Candida mogii. Product yields, Yp/s, of 0.41 and 0.37 g/g and cellular yields, Yx/s, of 0.24 and 0.13 g/g, respectively, were obtained using the two types of resin-treated hydrolyzates.
Squeeze Film Damping of Doubly Supported Ribbons in Noble Gas Atmospheres (1998)

Doubly supported MEMS ribbons of a Grating Light Valve device have been characterized for damping time when excited by an impulse in noble gas atmospheres. A simple linear relationship is found between the damping time of the ribbons and the gas viscosity when corrected for rarefaction effects.
Fibroblast Growth Factor Plays a Critical Role in SM22α Expression During Xenopus Embryogenesis (2000)

Although smooth muscle cells (SMCs) are critical components of the circulatory system, the regulatory mechanisms of SMC differentiation remain largely unknown. In the present study, we examined the mechanism of SMC differentiation by using Xenopus laevis SM22alpha (XSM22alpha) as an SMC-specific marker. XSM22alpha cDNA contained a 600-bp open reading frame, and the predicted amino acid sequences were highly conserved in evolution. XSM22alpha transcripts were first detected in heart anlage, head mesenchyme, and the dorsal side of the lateral plate mesoderm at the tail-bud stage, possibly representing the precursors of muscle lineage. At the tadpole stage, XSM22alpha transcripts were restricted to the vascular and visceral SMCs. XSM22alpha was strongly induced by basic fibroblast growth factor (FGF) in animal caps. Although expressions of Xenopus cardiac actin were not affected by the expression of a dominant-negative FGF receptor, its injection dramatically suppressed the XSM22alpha expression. These results suggest that XSM22alpha is a useful molecular marker for the SMC lineage in Xenopus and that FGF signaling plays an important role in the induction of XSM22alpha and in the differentiation of SMCs.
A global solution for robust parameter design of aeronautical electrical apparatus based on interactions analysis and polynomial fitting (2019)

Robust Parameter Design (RPD) has been widely applied for improving quality and reliability of products. One of the key drawbacks of applying RPD using Taguchi method is that the stable factors may not be independent of the adjustment factors, resulting in unsatisfactory design. Moreover, the Taguchi method cannot guarantee global optimality since the levels set in the experiment are usually discrete to ensure orthogonal design. In this paper, robust solutions of the stable factors are obtained via a nonlinear model based on polynomial fitting; while the adjustment factors are obtained via interactions analysis so that they are independent of the stable factors. In particular, the values of the adjustment factors are determined by output offset compensation so as to achieve robustness of the design scheme. An example on the design of an aeronautical electrical apparatus is presented to illustrate the procedure. The results show that the proposed method can take full advantage of the nonlinearity in the response and achieve the desired outcome.
Small heat-shock protein Hsp12 contributes to yeast tolerance to freezing stress (2009)

The HSP12 gene encodes one of the two major small heat-shock proteins of Saccharomyces cerevisiae and is induced under different conditions, such as low and high temperatures, osmotic or oxidative stress and high sugar or ethanol concentrations. However, few studies could demonstrate any correlation between HSP12 deletion or overexpression and a phenotype of sensitivity/resistance, making it difficult to attribute a role for Hsp12p under several of these stress conditions. We investigated the possible role of Hsp12p in yeast freezing tolerance. Contrary to what would be expected, the hsp12 null mutant when subjected to prolonged storage at -20 degrees C showed an increased resistance to freezing when compared with the isogenic wild-type strain. Because the mutant strain displayed a higher intracellular trehalose concentration than the wild-type, which could mask the effect of manipulating HSP12, we overexpressed the HSP12 gene in a trehalose-6-phosphate synthase (TPS1) null mutant. The tps1Delta strain overexpressing HSP12 showed an increase in resistance to freezing storage, indicating that Hsp12p plays a role in freezing tolerance in a way that seems to be interchangeable with trehalose. In addition, we show that overexpression of HSP12 in this tps1Delta strain also increased resistance to heat shock and that absence of HSP12 compromises the ability of yeast cells to accumulate high levels of trehalose in response to a mild heat stress.
Assistive Technologies for the Rehabilitation of the Arm following Stroke - The ATRAS Project - NIHR Programme Grant for Applied Research RP-PR-0707-10012 (2009)

Introduction About 50% of all acute stroke patients starting rehabilitation have marked functional impairment of the arm. Only 14% of these will regain any useful function. Assistive technologies (ATs) may be useful in Upper Limb Rehabilitation Following Stroke (ULRFS) - ATs being defined as a device used in a functional task orientated training process which will have a systemic or rehabilitative effect on the person. This includes constraint induced movement therapy, rehabilitation robots, functional electrical stimulation, active orthoses, biofeedback etc. Few clinical trials have assessed the rehabilitation benefits of AT’s alone or in combination. ATRAS therefore seeks to address this and develop an evidence based care pathway. Methods To identify the most promising AT’s and combinations via a series of work packages (WP’s). WP1-To determine current treatment methods and outcome measures used in England WP2- To determine what AT’s exist to improve upper limb function and undertake systematic reviews of each. WP3-To investigate any barriers to the use of AT’s by patients, clinicians and commissioners WP4- To undertake a clinical trial to assess the cost effectiveness of AT’s alone or in combination based on WP2 and WP3 and compare them with the current treatment defined in WP1 WP5-To propose a new service delivery model based on WP4 for an evidence based care pathway for ULRFS WP6- Dissemination We are keen to hear from anyone who has experience in ULRFS. This is a great chance for you to become involved and influence practice. Please contact joanna.regan@salisburyfes.com.
Reconfiguring UWB Monopole Antenna for Cognitive Radio Applications Using GaAs FET Switches (2012)

A novel ultrawideband (UWB) microstrip monopole antenna with reconfigurable multiband function is presented. Reconfigurability is achieved by using GaAs field effect transistor (FET) switches to connect multiple stubs of different lengths to the main feed line of the monopole. The antenna is compact and flexible in terms of the availability of different reconfiguration bands and, most importantly, the simple biasing of the GaAs FET switches will not have a severe effect on the antenna performance. Using GaAs FET switches did not degrade the antenna radiation patterns due to the simple biasing technique and the few external biasing components needed, besides these switches did not degrade the antenna gain and efficiency due to their low insertion loss and low on resistance. When the antenna was reconfigured from UWB to work into multiple frequency bands, the total peak gain improved by 20% compared to the UWB case. In addition, the total efficiency of the antenna has not been significantly reduced in any reconfigured band, whereas the out-of-band total efficiency is hugely reduced, which highlights the filtering role of the reconfiguration process. The total dc power consumption of the antenna switches is still very low (<; 33 μW), and this will lead to simple integration of the antenna in some portable communication systems or future cognitive radio front ends.
Users' guides to the medical literature. II. How to use an article about therapy or prevention. B. What were the results and will they help me in caring for my patients? Evidence-Based Medicine Working Group (1994)

<h3>CLINICAL SCENARIO</h3> You are a general internist who is asked to see a 65-year-old man with controlled hypertension and a 6-month history of atrial fibrillation resistant to cardioversion. Although he has no evidence for valvular or coronary heart disease, the family physician who referred him to you wants your advice on whether the benefits of long-term anticoagulants (to reduce the risk of embolic stroke) outweigh their risks (of hemorrhage from anticoagulant therapy). The patient shares these concerns and doesn't want to receive a treatment that would do more harm than good. You know that there have been randomized trials of warfarin for nonvalvular atrial fibrillation and decide that you'd better review one of them.
On the Long-term Stability of Satellite and Ground-based Ozone Profile Records (2017)

International audience
Teaching and learning with power and privilege: Student and teacher identity in education about gender-based violence (2022)

Gender-based violence (GBV) is a global concern that disproportionately impacts girls and marginalized communities; there is a need to better understand public education's role in enhancing understanding of GBV. This study uses qualitative participatory methods to study the experiences of 14 Canadian teachers who teach about GBV. Participants struggled to balance teaching their most privileged students about GBV while protecting students more likely to have experienced it directly. Feminist pedagogy of GBV should utilize strategies and curriculum that are action oriented and rooted in both the systemic contexts of GBV and the intersectional lived experiences of students and teachers.
On the Effectiveness of Virtual Reality-based Training for Robotic Setup (2020)

Virtual Reality (VR) is rapidly increasing in popularity as a teaching tool. It allows for the creation of a highly immersive, three-dimensional virtual environment intended to simulate real-life environments. With more robots saturating the industry - from manufacturing to healthcare, there is a need to train end-users on how to set up, operate, tear down, and troubleshoot the robot. Even though VR has become widely used in training surgeons on the psychomotor skills associated with operating the robot, little research has been done to see how the benefits of VR could translate to teaching the bedside staff, tasked with supporting the robot during the full end-to-end surgical procedure. We trained 30 participants on how to set up a robotic arm in an environment mimicking clinical setup. We divided these participants equally into 3 groups with one group trained with paper-based instructions, one with video-based instructions and one with VR-based instructions. We then compared and contrasted these three different training methods. VR and paper-based were highly favored training mediums over video-based. VR-trained participants achieved slightly higher fidelity of individual robotic joint angles, suggesting better comprehension of the spatial awareness skills necessary to achieve desired arm positioning. In addition, VR resulted in higher reproducibility of setup fidelity and more consistency in user confidence levels as compared to paper and video-based training.
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells (1993)

Autophagy, measured as the sequestration of an endogenous cytosolic enzyme (LDH), showed a progressive rate reduction during diethylnitrosamine-induced rat liver carcinogenesis. In primary hepatocellular carcinomas the autophagic activity was only one-fourth of that seen in normal hepatocytes. Reduced autophagy was also observed in peritumorous hepatocytes and in cells from preneoplastic liver, and a complete suppression of autophagic protein degradation was seen in normal hepatocytes treated with ascitic fluid from an ascites hepatoma, suggesting that tumour cells and their precursors may produce autophagy-suppressive factors with an autocrine and paracrine action. In cells from the transplantable rat ascites hepatoma, Yoshida AH-130, autophagic activity was negligible during active (logarithmic) growth, but increased to approximately 0.4%/h at high cell density, i.e. in stationary phase. In contrast to normal hepatocytes, autophagy in the AH-130 cells was not inhibited by ascitic fluid. The hepatoma cells would thus appear to have lost some aspects of autophagy regulation while retaining others. However, even the highest rate of hepatoma cell autophagy was only one-tenth of the maximal activity seen in normal hepatocytes, confirming the hypothesis that reduced autophagy may be an important aspect of growth deregulation in liver cancer.
Ligand and alkali metal cation control on the molecular complexity of anionic chromium(II) aryloxides. Preparation and crystal structure of dimeric (PhO)10Cr2Li6(THF)6 and (2,6-Me2C6H3O)6Cr2Li2(THF)4 and trimeric (GuO)14Cr3Na9Cl [GuO = (o-CH3O)C6H4O] with an encapsulated chloride ion (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand and alkali metal cation control on the molecular complexity of anionic chromium(II) aryloxides. Preparation and crystal structure of dimeric (PhO)10Cr2Li6(THF)6 and (2,6-Me2C6H3O)6Cr2Li2(THF)4 and trimeric (GuO)14Cr3Na9Cl [GuO = (o-CH3O)C6H4O] with an encapsulated chloride ionJilles J. H. Edema, Auke Meetsma, Sandro Gambarotta, Saeed I. Khan, Wilberth J. J. Smeets, and Anthony L. SpekCite this: Inorg. Chem. 1991, 30, 19, 3639–3646Publication Date (Print):September 18, 1991Publication History Published online1 May 2002Published inissue 18 September 1991https://pubs.acs.org/doi/10.1021/ic00019a014https://doi.org/10.1021/ic00019a014research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Impedance Model for a Concentrated Solution: Application to the Electrodissolution of Copper in Chloride Solutions (1984)

International audience
Matched Comparison of Hearing Outcomes in Patients With Vestibular Schwannoma Treated With Stereotactic Radiosurgery or Observation (2022)

When controlling for potential confounders, there was no significant difference in loss of class A or serviceable hearing between patients managed with SRS or with observation alone.
Insecticidal properties of a crystal protein gene product isolated from Bacillus thuringiensis subsp. kenyae (1992)

A protoxin gene, localized to a high-molecular-weight plasmid from Bacillus thuringiensis subsp. kenyae, was cloned on a 19-kb BamHI DNA fragment into Escherichia coli. Characterization of the gene revealed it to be a member of the CryIE toxin subclass which has been reported to be as toxic as the CryIC subclass to larvae from Spodoptera exigua in assays with crude E. coli extracts. To directly test the purified recombinant gene product, the gene was subcloned as a 4.8-kb fragment into an expression vector resulting in the overexpression of a 134-kDa protein in the form of phase-bright inclusions in E. coli. Treatment of solubilized inclusion bodies with either trypsin or gut juice from the silkworm Bombyx mori resulted in the appearance of a protease-resistant 65-kDa protein. In force-feeding bioassays, the purified activated protein was highly toxic to larvae of B. mori but not to larvae of Choristoneura fumiferana. In diet bioassays with larvae from S. exigua, the purified protoxin was nontoxic. However, prior activation of the protoxin by tryptic digestion resulted in the appearance of some toxic activity. These results demonstrate that this new subclass of protein toxin may not be useful for the control of Spodoptera species as previously reported. Hierarchical clustering of the nine known lepidopteran-specific CryI toxin subclasses through multiple sequence alignment suggests that the toxins fall into four possible subgroups or clusters.