gebhart/patrepeval huggingface dataset:
Enzymic modification of proteins: effects of transglutaminase cross-linking on some physical properties of .beta.-lactoglobulin (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic modification of proteins: effects of transglutaminase cross-linking on some physical properties of .beta.-lactoglobulinShin Ya Tanimoto and John E. KinsellaCite this: J. Agric. Food Chem. 1988, 36, 2, 281–285Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jf00080a010https://doi.org/10.1021/jf00080a010research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Nucleophilic Hydroboration of Substituted Styrenes with Lithium Triethylborohydride. A Simple Convenient Procedure for the Markownikoff Hydroboration of Aromatically Conjugated Olefins and the Synthesis of Mixed Organoboranes with the Benzylic (α‐Arylalkyl) Moiety. (1977)

Abstract Styrole (I) werden mit den Boranen (II) über die Salze (III) in die Hydrierungsprodukte (IV) übergeführt.
Audit of electronic operative documentation in interventional radiology: the value of standardised proformas (2020)

The construction of a procedure-specific perioperative electronic proforma can save clinicians valuable time and encourage safe and effective clinical documentation.
Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons (2006)

T-type calcium channels are thought to transform neuronal output to a burst mode by generating low voltage-activated (LVA) calcium currents and rebound burst discharge. In this study we assess the expression pattern of the three different T-type channel isoforms (Ca(v)3.1, Ca(v)3.2, and Ca(v)3.3) in cerebellar neurons and focus on their potential role in generating LVA spikes and rebound discharge in deep cerebellar nuclear (DCN) neurons. We detected expression of one or more Ca(v)3 channel isoforms in a wide range of cerebellar neurons and selective expression of different isoforms in DCN cells. We further identify two classes of large-diameter DCN neurons that exhibit either a strong or weak capability for rebound discharge, despite the ability to generate LVA spikes when calcium currents are pharmacologically isolated. By correlating the Ca(v)3 channel expression pattern with the electrophysiological profile of identified DCN cells, we show that Ca(v)3.1 channels are expressed in isolation in DCN-burst cells, whereas Ca(v)3.3 is expressed in DCN-weak burst cells. Ca(v)3.1-expressing DCN cells correspond to excitatory or GABAergic neurons, whereas Ca(v)3.3-expressing cells are non-GABAergic. The Ca(v)3 class of LVA calcium channels is thus expressed in specific combinations in a wide range of cerebellar neurons but contributes to rebound burst discharge in only a select number of cell classes.
MagPad (2015)

In this paper, we present a novel near surface augmented reading system that brings digital content to physical papers. Our system allows a collocated mobile phone to provide augmented content based on its position on top of paper. Our system utilizes built-in magnetometer of a smartphone together with six constantly spinning magnets that generate designed patterns of magnetic flux, to detect 2D location of phone and render dynamic interactive content on the smartphone screen. The proposed technique could be implemented on most of mobile platforms without external sensing hardware.
Laser Shot Peening System Final Report CRADA No. TC-1369-96 (2017)

This CRADA project was established with a primary goal to develop a laser shot peening system which could operate at production throughput rates and produce the desired depth and intensity of induced shots. The first objective was to understand all parameters required for acceptable peening, including pulse energy, pulse temporal format, pulse spatial format, sample configuration and tamping mechanism. The next objective was to demonstrate the technique on representative samples and then on representative parts. The final objective was to implement the technology into a meaningful industrial peen.
Experimental study of horizontal in-tube condensation (1976)

The condensation of low pressure steam inside smooth and augmented horizontal tubes has been experimentally investigated. Smooth tubes were tested to establish reference conditions and to check existing in-tube condensation heat transfer predictive methods. Inclined tubes, twisted-tape inserts, and internally finned tubes were tested as passive techniques to augment in-tube condensation. Tube inclination produced only modest improvements in heat transfer. Twisted tapes with pitch-diameter ratios of 3.8 and 7.0 were tested and found to increase heat transfer coefficients by as much as 30% above the empty tube values on a nominal area basis. Four internally finned tubes were also tested. They produced increases in heat transfer coefficients as much as 150% above the smooth tube values on a nominal area basis.
Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats (2014)

The potential pharmacokinetic (PK) interaction of conventional western drug, baclofen, and oriental medications Oyaksungisan (OY) and Achyranthes bidentata radix (AB) extract for the treatment of spasticity has been evaluated. Rats were pretreated with distilled water (DW), OY, or AB extract by oral administration every day for 7 days. After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma concentrations of baclofen were determined by LC/MS/MS. The plasma baclofen concentration-time profiles were then analyzed by noncompartmental analysis and a population PK model was developed. Baclofen was rapidly absorbed, showed biexponential decline with elimination half-life of 3.42-4.10 hr, and mostly excreted into urine. The PK of baclofen was not affected by AB extract pretreatment. However, significantly lower maximum plasma concentration (C max) and longer time to reach C max (T max) were observed in OY pretreated rats without changes in the area under the curve (AUC) and the fraction excreted into urine (F urine). The absorption rate (K a ) of baclofen was significantly decreased in OY pretreated rats. These data suggested that repeated doses of OY might delay the absorption of baclofen without changes in extent of absorption, which needs further evaluation for clinical significance.
Hydration Forces (1993)

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for an ML revolution and have already been profoundly affected by the application of existing ML ...Read More
Current Status of Synthetic Epikeratoplasty (1991)

Many of the deficiencies with human tissue epikeratoplasty might be improved by the use of a suitable synthetic lenticule. Potential biomaterials for epikeratoplasty include collagen (types I, III, or IV), collagen-hydrogel copolymers, bioactive synthetics, and coated hydrogels. The biomaterial must be engineered to achieve strict specifications of optical clarity, support of epithelial migration and adhesion, permeability to solutes, and stability to corneal proteases. Attaching synthetic lenticules to the cornea without cutting Bowman's layer by adhesives, laser welding, or direct adhesion may also improve the efficacy of synthetic epikeratoplasty.
Nanoparticles for Detection and Treatment of Peripheral Arterial Disease (2018)

Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional capacity. Although the PAD occurrence rate is increasing in the elderly population, outcomes with current treatment strategies are suboptimal. Hence, there is an urgent need to develop new technologies that overcome limitations of traditional modalities for PAD detection and therapy. In this Review, the application of nanotechnology as a tool that bridges the gap in PAD diagnosis and therapy is in focus. Several materials including synthetic, natural, biodegradable, and biocompatible materials are used to develop nanoparticles for PAD diagnostic and/or therapeutic applications. Moreover, various recent research approaches are being explored to diagnose PAD through multimodality imaging with different nanoplatforms. Further efforts include targeted delivery of various therapeutic agents using nanostructures as carriers to treat PAD. Last, but not least, despite being a fairly new field, researchers are exploring the use of nanotheranostics for PAD detection and therapy.
Supplementary Figure 2 from Microtubule-Disrupting Chemotherapeutics Result in Enhanced Proteasome-Mediated Degradation and Disappearance of Tubulin in Neural Cells (2023)

Supplementary Figure 2 from Microtubule-Disrupting Chemotherapeutics Result in Enhanced Proteasome-Mediated Degradation and Disappearance of Tubulin in Neural Cells
Identification of Structural‐Activity Features of Long Chain Polyunsaturated Fatty Acid Epoxides in Angiogenesis (2018)

The cytochrome P450‐derived fatty acid epoxides are bioactive lipids with regulatory roles in a wide range of homeostatic and pathophysiological events. These lipid mediators are metabolized efficiently by the mammalian soluble epoxide hydrolase enzyme (sEH) to corresponding 1,2‐diols. Inhibition of sEH has been shown to be beneficial to human health via increasing concentrations of a variety of short‐lived epoxylipids in vivo (2). Identifying the most potent polyunsaturated fatty acid (PUFA) epoxide metabolites will provide insight on the effects of sEH inhibition. Recent studies have shown that the omega‐6 epoxyeicosatrienoic acids (EETs) from arachidonic acid are pro‐angiogenic, while the omega‐3, docosahexaenoic acid (DHA)‐derived epoxydocosapentaenoic acids (EDPs) inhibit angiogenesis, tumor growth, and metastasis (1). Given these findings, we are interested in exploring the roles of various long chain PUFA epoxides in angiogenesis. We tested a library of omega‐3 and omega‐6 epoxides in a newly developed high‐throughput tube formation assay and found their effects are regiospecific and stereospecific; Of note, the 19(S),20(R)‐EDP stereoisomer was a less effective inhibitor of endothelial cell tube formation than its respective racemic mixture. Here, we report the angiogenic activities of diverse omega‐3 and omega‐6 fatty acid epoxides that could be present in mammals from the diet, including the less explored epoxides from both omega‐3 and omega‐6 docosapentaenoic acid (DPA). We will discuss the structure‐activity features of the most potent epoxide species and also present methodology to synthesize and purify the regioisomers and stereoisomers of each series of epoxides. Ultimately, understanding activities of sEH substrates in specific regulatory environments will guide development of targeted sEH modulators that promote the beneficial effects of PUFA metabolites in human health and disease. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Humidity estimation using neural network and optical fiber sensor (2009)

Abstract An optical fiber (OF) sensor with enhanced dynamic range and high sensitivity is realized to detect varying range of relative humidity (RH). For precise and independent estimation/prediction of RH from its nonlinear response, feed forward artificial neural network (ANN) model is developed. Preprocessed stable sensor outputs and corresponding commercial sensor outputs were used to train ANN. Results show that ANN has been effective in successfully predicting RH from the response of OF sensor. Overall, neural network approach showed better performance in comparison to alternative calibration method. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 641–645, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24132
Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease (2005)

Huntington's disease (HD) is an adult-onset neurodegenerative disorder involving motor dysfunction, cognitive deficits, and psychiatric disturbances that result from underlying striatal and cortical dysfunction and neuropathology. The YAC128 mouse model of HD reproduces both the motor deficits and selective degeneration observed in the human disease. However, the presence of cognitive impairment in this model has not been determined. Here, we report mild cognitive deficits in YAC128 mice that precede motor onset and progressively worsen with age. Rotarod testing revealed a motor learning deficit at 2 months of age that progresses such that by 12 months of age, untrained YAC128 mice are unable to learn the rotarod task. Additional support for cognitive dysfunction is evident in a simple swimming test in which YAC128 mice take longer to find the platform than wild-type (WT) controls beginning at 8 months of age. YAC128 mice also have deficits in open-field habituation and in a swimming T-maze test at this age. Strikingly, in the reversal phase of the swimming T-maze test, YAC128 mice take twice as long as WT mice to locate the platform, indicating a difficulty in changing strategy. At 12 months of age, YAC128 mice show decreased prepulse inhibition and habituation to acoustic startle. The clear pattern of cognitive dysfunction in YAC128 mice is similar to the symptoms and progression of cognitive deficits in human HD and provides both the opportunity to examine the relationship between cognitive dysfunction, motor impairment, and neuropathology in HD and to assess whether potential therapies for HD can restore cognitive function.
Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers (2019)

Heterozygous PDLIM5 variants are rare and therefore will not have a major contribution in DCM. Although they likely play a role in disease development as this gene plays a major role in contracting cardiomyocytes and homozygous variants lead to early-onset cardiac disease. Other environmental and/or genetic factors are probably necessary to unveil the cardiac phenotype in PDLIM5 mutation carriers.
Pathway Selection in Peptide Amphiphile Assembly (2014)

The nature of supramolecular structures could be strongly affected by the pathways followed during their formation just as mechanisms and final outcomes in chemical reactions vary with the conditions selected. So far this is a largely unexplored area of supramolecular chemistry. We demonstrate here how different preparation protocols to self-assemble peptide amphiphiles in water can result in the formation of different supramolecular morphologies, either long filaments containing β-sheets or smaller aggregrates containing peptide segments in random coil conformation. We found that the assembly rate into β-sheets decreases in the presence of a destabilizing "good" solvent like hexafluoroisopropanol (HFIP) and is affected by transient conditions in solution. Also the peptide amphiphile investigated spontaneously nucleates the β-sheet-containing filaments at a critical fraction of HFIP in water below 21%. Furthermore, β-sheet assemblies have a high kinetic stability and, once formed, do not disassemble rapidly. We foresee that insights into the characteristic dynamics of a supramolecular system provide an efficient approach to select the optimum assembly pathway necessary for function.
Herpes simplex virus DNA in transformed cells: sequence complexity in five hamster cell lines and one derived hamster tumor (1976)

Analyses of the hybridization kinetics of labeled herpes simplex virus 2 (HSV-2) DNA with DNA from five hamster cell lines transformed by UV light-irradiated HSV-2 revealed the following. (i) Viral DNA sequences were detected in all five cell lines tested. (ii) None of the cell lines contained the full complement of HSV-2 DNA. (iii) The amount of viral DNA present in the cells varied in different transformed cell lines and ranged from 8 to 32% of the HSV-2 DNA genome in 1 to 3 copies/cell. (iv) Two parallel passages of the same cell line (333-2-29) differed in the amount of viral DNA they contained. We also compared the viral DNA sequences present in (i) one transformed cell line (333-8-9) propagated serially in culture for 80 passages, (ii) a tumor produced by inoculation of a newborn hamster with the 333-8-9 cells, and (iii) a cell line derived from a hamster tumor as above and propagated in culture for 32 passages. The results show that viral DNA present in the hamster tumor and in the cells derived from the tumor had a lower sequence complexity than that present in the original serially passaged 333-8-9 cell line.
One‐Pot Cascade Synthesis of (3S)‐Hydroxyketones Catalyzed by Transketolase via Hydroxypyruvate Generated in Situ from d‐Serine by d‐Amino Acid Oxidase (2019)

Abstract We described an efficient in situ generation of hydroxypyruvate from d ‐serine catalyzed by a d ‐amino acid oxidase from Rhodotorula gracilis . This strategy revealed an interesting alternative to the conventional chemical synthesis of hydroxypyruvate starting from toxic bromopyruvate or to the enzymatic transamination from l ‐serine requiring an additional substrate as amino acceptor. Hydroxypyruvate thus produced was used as donor substrate of transketolases from Escherichia coli or from Geobacillus stearothermophilus catalyzing the stereoselective formation of a carbon−carbon bond. The enzymatic cascade reaction was performed in one‐pot in the presence of d ‐serine and appropriate aldehydes for the synthesis of valuable (3 S )‐hydroxyketones, which were obtained with high enantio‐ and diastereoselectivity and in good yield. The efficiency of the process was based on the irreversibility of both reactions allowing complete conversion of d ‐serine and aldehydes. magnified image
Properties of (Fe,Co)-(Ta,W) amorphous alloy films deposited by rf sputtering (1981)

Magnetic and thermal properties of the amorphous films of (Fe,Co) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">100-x</inf> (Ta,W) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> , ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4\leq\times\leq30</tex> ) deposited by a rf diode sputtering have been investigated. The amorphous films were obtained for Ta or W content 'X' above 14 at.%. The dependence of 4πMs on X of the deposited films was examined in detail. The change of crystal structure of the films from the crystalline phase to the amorphous one at X=14 at.% with increase in X leads to a drastical decrease in 4πMs of the Fe-Ta films. The dependence of 4πMs on X of the Fe-W films is similar to that of the Fe-Ta films. On the other hand, 4πMs of the Co-Ta films decreases gradually with increase in X, even if the crystal structure changes from the crystalline phase to the amorphous one. The maximum 4πMs and the minimum coercive force Hc of the amorphous Co-Ta films are 10 kG and 0.57 Oe, respectively. The crystallization temperatures of the amorphous Co-Ta films are above 800 K, being much higher than those of 3d-transition metal-metalloid amorphous alloys. They may be useful as a soft magnetic material with high thermal Stability.
Epidemiology of periprosthetic femoral fractures in 5417 revision total hip arthroplasties (2016)

In revision THA, intra-operative periprosthetic femoral fractures occur three times more often with uncemented stems. Many are non-displaced diaphyseal fractures treated with cerclage fixation. While postoperative fracture risks are equivalent between uncemented and cemented components, they occur at notably different time periods based on stem fixation type.
Fabrication of holographic diffraction gratings based on As2S3 Layers (2003)

The formation of holographic diffraction gratings based on As2S3 layers is investigated. The variation of the groove profiles with exposure is studied by atomic force microscopy. The spectral curves of the diffraction efficiency are taken, and a relationship between these curves and grating surface relief is analyzed.
Designing 129Xe NMR Biosensors for Matrix Metalloproteinase Detection (2006)

Xenon-129 biosensors offer an attractive alternative to conventional MRI contrast agents due to the chemical shift sensitivity and large nuclear magnetic signal of hyperpolarized (129)Xe. Here, we report the first enzyme-responsive (129)Xe NMR biosensor. This compound was synthesized in 13 steps by attaching the consensus peptide substrate for matrix metalloproteinase-7 (MMP-7), an enzyme that is upregulated in many cancers, to the xenon-binding organic cage, cryptophane-A. The final coupling step was achieved on solid support in 80-92% yield via a copper (I)-catalyzed [3+2] cycloaddition. In vitro enzymatic cleavage assays were monitored by HPLC and fluorescence spectroscopy. The biosensor was determined to be an excellent substrate for MMP-7 (K(M) = 43 microM, V(max) = 1.3 x 10(-)(8) M s(-1), k(cat)/K(M) = 7,200 M(-1) s(-1)). Enzymatic cleavage of the tryptophan-containing peptide led to a dramatic decrease in Trp fluorescence, lambda(max) = 358 nm. Stern-Volmer analysis gave an association constant of 9000 +/- 1,000 M(-1) at 298 K between the cage and Trp-containing hexapeptide under enzymatic assay conditions. Most promisingly, (129)Xe NMR spectroscopy distinguished between the intact and cleaved biosensors with a 0.5 ppm difference in chemical shift. This difference most likely reflected a change in the electrostatic environment of (129)Xe, caused by the cleavage of three positively charged residues from the C-terminus. This work provides guidelines for the design and application of new enzyme-responsive (129)Xe NMR biosensors.
A Comparison of Virtual and Conventional Colonoscopy for the Detection of Colorectal Polyps (1999)

In a group of patients at high risk for colorectal neoplasia, virtual and conventional colonoscopy had similar efficacy for the detection of polyps that were 6 mm or more in diameter.