gebhart/patrepeval huggingface dataset:
Parsimonious Mixed Models (2015)

The analysis of experimental data with mixed-effects models requires decisions about the specification of the appropriate random-effects structure. Recently, Barr, Levy, Scheepers, and Tily, 2013 recommended fitting `maximal' models with all possible random effect components included. Estimation of maximal models, however, may not converge. We show that failure to converge typically is not due to a suboptimal estimation algorithm, but is a consequence of attempting to fit a model that is too complex to be properly supported by the data, irrespective of whether estimation is based on maximum likelihood or on Bayesian hierarchical modeling with uninformative or weakly informative priors. Importantly, even under convergence, overparameterization may lead to uninterpretable models. We provide diagnostic tools for detecting overparameterization and guiding model simplification.
Finger injuries by fast rotating blades: A case report of an accident with a blender and the intervention of the fire brigade (2014)

We present a case report of a 27-year-old female who had an accident with a blender. She was brought to the Emergency Department having pinched her left forefinger between the blades. Previous attempts by the local fire brigade to free the finger initially failed. After several attempts it finally succeeded by turning it carefully away from the blade. Although first impressions of the accident might have expected a worse injury, fortunately it just showed a nail bed cut. Most accidents of this type cause serious injuries with the involvement of vessels, nerves, tendons, muscles or bones.
Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage (2000)

Ser-15 of human p53 (corresponding to Ser-18 of mouse p53) is phosphorylated by ataxia-telangiectasia mutated (ATM) family kinases in response to ionizing radiation (IR) and UV light. To determine the effects of phosphorylation of endogenous murine p53 at Ser-18 on biological responses to DNA damage, we introduced a missense mutation (Ser-18 to Ala) by homologous recombination into both alleles of the endogenous p53 gene in mouse embryonic stem (ES) cells. Our analyses showed that phosphorylation of murine p53 at Ser-18 in response to IR or UV radiation was required for a full p53-mediated response to these DNA damage-inducing agents. In contrast, phosphorylation of p53 at Ser-18 was not required for ATM-dependent cellular resistance after exposure to IR. Additionally, efficient acetylation of the C terminus of p53 in response to DNA damage did not require phosphorylation of murine p53 at Ser-18.
Efficient Designs for AOP-Based Field Multiplication over GF(2 m ) (2011)

In this paper, we present an efficient recursive formulation and systolic implementation of poly- nomial basis finite field multiplication over GF(2 m ) based on irreducible all-one-polynomials (AOP). Using the property of irreducible AOP we have obtained a scheme of computation-free modular-reduction up to de- gree m, where reduction of degree is achieved by cyclic-left-shift operations. In the proposed systolic archi- tecture, the cyclic-left-shift has been achieved by appropriate reordering of input lines in the processing ele- ments (PEs). Compared with the previously existing systolic structures, the proposed one is found to involve significantly less number of registers and requires nearly half the area-time complexity. It is shown that the proposed structure requires nearly the same number of gates as those of the existing bit-parallel structures. Unlike the existing bit-parallel designs, it does not require rewiring of input lines, and critical path of pro- posed structure does not increase with the field order m. For m > 17 (which is required in most practical cas- es), the proposed systolic design is found to have significantly less area-time complexity compared with the existing bit-parallel structures.
Selective co‐stimulation of pudendal afferents enhances bladder activation and improves voiding efficiency (2013)

Both types of co-stimulation evoked larger bladder contractions and increased VE over individual branch PN afferent stimulation and distention-evoked voiding. The decreased threshold volumes required for reflex bladder activation and increased VEs with co-stimulation support the use of stimulation of multiple individual stimulation-evoked reflexes to improve voiding efficiency.
Energy and Spectrum Efficiency with Multi-Flow Transponders and Elastic Regenerators in Survivable Flexible Bandwidth Virtual Optical Networks (2014)

Survivable energy-aware and spectrum-aware approaches (SEA/SSA) are developed to minimize energy and spectrum consumption in flexible bandwidth virtual optical networks. Simulation results show that SEA and SSA can efficiently reduce energy and spectrum consumption, respectively.
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src) (protein kinase/phosphoprotein/membrane protein/viral oncogenesis) (2016)

The transforming protein (pp60Src) of Rous sar- coma virus (RSV) is a phosphoprotein with the enzymatic ability to phosphorylate tyrosine in protein substrates. Previous work has indicated that the bulk of pp60src may be attached to the plasma membrane of infected cells. In an effort to better understand the mechanism by which pp60src induces the neoplastic phenotype, we have characterized further the attachment of pp60src to the plasma membrane, and we have identified separate molecular domains that are responsible for the attachment to membranes and for the protein kinase activity. Our results indicate that pp60src may be an integral membrane protein that is nevertheless synthesized on soluble polyribosomes. Subsequent to its synthesis, the protein attaches to plasma membrane without concomitant cleavage of a signal polypeptide. The amino-terminal quarter (or some portion thereof) of pp60src anchors the protein to the plasma membrane by forces that can be disrupted only with detergents. By contrast, protein kinase activity is located in the carboxyl-terminal half of the molecule. It appears that pp60src is designed on the one hand for tethering to the plasma membrane and on the other hand for enzymatic activity beyond the confines of the membrane. The fact that pp60src is but one of at least four different viral transforming proteins located on the plasma membrane implies that neoplastic transformation may commonly originate in events that occur at the periphery of the cell.
NSAIDs Overcome PIK3CA Mutation-Mediated Resistance to EGFR Inhibition in Head and Neck Cancer Preclinical Models (2022)

Epidermal growth factor receptor (EGFR) inhibitors are approved by the Food and Drug Administration (FDA) but remain under active clinical investigation for the treatment of both newly diagnosed and recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Despite EGFR expression in the majority of HNSCC tumors, the levels of total or phosphorylated EGFR have not consistently been correlated with a response to EGFR targeting agents. The lack of predictive biomarkers represents a major obstacle to successful use of these drugs. Activation of phosphatidylinositol 3-kinase (PI3K) signaling by mutation of the <i>PIK3CA</i> oncogene represents a plausible mechanism for EGFR inhibitor drug resistance. We compared the impact of EGFR inhibitors, alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs), in preclinical HNSCC models harboring mutant versus wild-type <i>PIK3CA</i>. Our results demonstrate additive or synergistic effects of NSAIDs and EGFR inhibitors in vitro and in vivo in <i>PIK3CA</i>-mutated HNSCC models. These findings suggest that the addition of NSAIDs to EGFR inhibitors for the treatment of HNSCC may represent a promising therapeutic strategy in <i>PIK3CA</i>-mutated cancers.
Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy (2017)

Anti-MAG (myelin-associated glycoprotein) neuropathy is a disabling autoimmune peripheral neuropathy caused by monoclonal IgM autoantibodies that recognize the carbohydrate epitope HNK-1 (human natural killer-1). This glycoepitope is highly expressed on adhesion molecules, such as MAG, present in myelinated nerve fibers. Because the pathogenicity and demyelinating properties of anti-MAG autoantibodies are well established, current treatments are aimed at reducing autoantibody levels. However, current therapies are primarily immunosuppressive and lack selectivity and efficacy. We therefore hypothesized that a significant improvement in the disease condition could be achieved by selectively neutralizing the pathogenic anti-MAG antibodies with carbohydrate-based ligands mimicking the natural HNK-1 glycoepitope 1. In an inhibition assay, a mimetic (2, mimHNK-1) of the natural HNK-1 epitope blocked the interaction of MAG with pathogenic IgM antibodies from patient sera but with only micromolar affinity. Therefore, considering the multivalent nature of the MAG-IgM interaction, polylysine polymers of different sizes were substituted with mimetic 2. With the most promising polylysine glycopolymer PL<sub>84</sub>(mimHNK-1)<sub>45</sub> the inhibitory effect on patient sera could be improved by a factor of up to 230,000 per epitope, consequently leading to a low-nanomolar inhibitory potency. Because clinical studies indicate a correlation between the reduction of anti-MAG IgM levels and clinical improvement, an immunological surrogate mouse model for anti-MAG neuropathy producing high levels of anti-MAG IgM was developed. The observed efficient removal of these antibodies with the glycopolymer PL<sub>84</sub>(mimHNK-1)<sub>45</sub> represents an important step toward an antigen-specific therapy for anti-MAG neuropathy.
Electroconvulsive Therapy in a Depressed Heart Transplant Patient. (1992)

Medication-resistant major depression was diagnosed in a 67-year-old man 1 1/2 years after heart transplantation. Electroconvulsive therapy was administered, resulting in remarkable improvement in depressive symptoms without complications related to the cardiac condition.
Reversible Low-Density Parity-Check Codes (2009)

Low-density parity-check (LDPC) codes may be decoded using a circuit implementation of the sum-product algorithm which maps the factor graph of the code. By reusing the decoder for encoding, both tasks can be performed using the same circuit, thus reducing area and verification requirements. Motivated by this, iterative encoding techniques based upon the graphical representation of the code are proposed. Code design constraints which ensure encoder convergence are presented, and then used to design iteratively encodable codes, while also preventing 4-cycle creation. We show how the Jacobi method for iterative matrix inversion can be applied to finite field matrices, viewed as message passing, and employed as the core of an iterative encoder. We present an algebraic construction of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</i> -cycle free iteratively encodable codes using circulant matrices. Analysis of these codes identifies a weakness in their structure, due to a repetitive pattern in the factor graph. The graph supports pseudo-codewords of low pseudo-weight. In order to remove the repetitive pattern in the graph, we propose a recursive technique for generating iteratively encodable codes. The new codes offer flexibility in the choice of code length and rate, and performance that compares well to randomly generated, quasi-cyclic and extended Euclidean-geometry codes.
Temporary and permanent enhancement of the magnetoimpedance response of amorphous wires (2005)

Melt extracted amorphous wires have a predominantly helical anisotropy due to residual tensile and torsional stresses quenched in the wire during casting. Consequently, their magnetoimpedance (MI) response is inadequate for linear detection of magnetic field. Several methods are used to accomplish this, both temporary (dc current biasing of the wire, tensile stress applied to the wire, or both) and permanent (current annealing of the wire, with or without applying a tensile stress). Their purpose is to optimize the MI response of these wires. The transverse (circumferential) anisotropy of the wire reaches an optimum in magnitude and orientation when a temporary method is used. This optimum can be quenched in the material using a permanent method. The MI response is characterized with the help of three criteria: sensitivity, figure of merit and peak amplitude per wire unit length. Magnetic field sensors with sensitivities as high as 75V∕(Tmm), figures of merit of about 0.5ΩT∕m, and peak amplitudes of 5Ω∕mm were obtained as a result of the enhancement of the MI response.
Back Performance Scale for the Assessment of Mobility-Related Activities in People With Back Pain (2002)

The BPS appears to measure an aspect of physical performance that is of clinical importance to patients with back pain.
Python for Prototyping Computer Vision Applications (2010)

Python is a popular language widely adopted by the scientific community due to its clear syntax and an extensive number of specialized packages. For image processing or computer vision development, two libraries are prominently used: NumPy/SciPy and OpenCV with a Python wrapper. In this paper, we present a comparative evaluation of both libraries, assessing their performance and their usability. We also investigate the performance of OpenCV when accessed through a python wrapper versus directly using the native C implementation.
Islanding detection using decision tree approach (2010)

Islanding occurs when part of a distribution network is disconnected from the rest of the power system but continues to be energized by a distributed resource (DR). Failure to trip the islanded DR can lead to serious problems for this DR and the connected loads. One method of islanding detection utilizes and combines different system parameters by using data mining technology and a multifunction software model to extract information from these data sets. It also detects the threshold settings for the islanding relays. Using the same methodology, an attempt has been made in this study to simulate the network and obtain the threshold settings by selecting a new set of parameters. Good accuracy was observed when compared to the data mining approach in spite of choosing a different set of parameters. The main advantage is parameters chosen are easily measured and the software tools used are readily available.
High resolution broadband photonic sampled ADC: 8.0 ENOB at 40 GHz (2014)

A broadband photonic Analog-to-Digital Converter based on high frequency optical sampling utilizing a dual-output-Mach-Zehnder modulator operating with frequencies up to 50-GHz is presented. The ADC performance is characterized with 8.0 ENOB at 40-GHz.
Venous thromboembolism risk and prophylaxis in the acute hospital care setting: report from the ENDORSE study in Egypt (2012)

In Egypt, more than one-third of all patients hospitalized for surgery or acute medical conditions are at high risk for developing VTE. However, only a small fraction of these patients receive appropriate VTE prophylaxis. Corrective measures are necessary for preventing VTE morbidity and mortality in these high risk patients.
Recent Advances of Toxic Cyanobacteria Researches (1999)

Toxic blooms of cyanobacteria occur in eutrophicated lakes, pond and river over the world. Cyanobacteria have produced acute toxins such as hepatotoxic peptides, microcystins and nodularins, and neurotoxic alkaloids, anatoxin-a, anatoxin-a(s) and saxitoxins. Microcystis, Oscillatoria, Anabaena, Aphanizomenon and Nodularia produce these toxins and have been responsible for the death of wild and domestic animals drinking water contaminated with blooms. A new hepatotoxin, cylindrospermopsin was also isolated from Cylindrospermopsis and Umezakia. The principal species under investigation is Microcystis aeruginosa, which has been frequently cited in animal poisoning incidents and produces strongly hepatotoxic cyclic heptapeptides named microcystins. Very recently, a toxic accident of 50 person's death occurred in Brazil in 1996 due to microcystin in the water for hemodialysis. The toxins consist of seven amino acids and approximately 60 components have been isolated so far. The toxins also inhibit protein phosphatases 1 and 2A in a manner similar to okadaic acid and have a tumor-promoting activity on the rat liver. Now microcystins are threatening human health and life, and many problems associated with microcystins remains to be solved. Since the total structures of microcystins were determined in 1984 by Botes group, many results obtained from various fields have been extensively accumulated. They are mainly classified into the following categories : 1) ecological aspects including taxonomy and toxic waterbloom formation, 2) production, occurrence and fate of microcystins, 3) chemistry and detection, 4) toxicology and health effects, 5) regulation of toxic cyanobacteria and 6) water treatment for removal of microcystins. Thie review overviews mainly the recent advance of microcystin researches in addition to the Caruaru incident.
Big Data im Störmanagement. (2014)

Storungen in der Produktion sind die Ursache weitreichender Auswirkungen auf den Wertschopfungsprozess. Mit der Vierten Industriellen Revolution (Industrie 4.0) und der damit verbundenen Informatisierung der Produktion nimmt die Generierung von Informationen uber den gesamten Produktionsprozess weiter zu. Die vielfaltigen und heterogenen Daten stellen die Unternehmen vor verschiedene Herausforderungen. Besonders das Fehlen eines Konzeptes fur ein ganzheitliches Storungsmanagement verhindert die zielgerichtete Nutzung der generierten Daten. Big Data stellt hier einen technischen Enabler dar, der eine Antizipation und Fruherkennung von Storungen im Produktionsprozess noch bevor diese eintreten ermoglicht und somit als Grundlage fur ein proaktiven Storungsmanagement dient. Eine Entstorung kann somit fruher und gezielter erfolgen.
Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay (2020)

The actin cytoskeleton is regulated by many proteins including capping proteins that stabilize actin filaments (F-actin) by inhibiting actin polymerization and depolymerization. Here, we report two pediatric probands who carry damaging heterozygous de novo mutations in CAPZA2 (HGNC: 1490) and exhibit neurological symptoms with shared phenotypes including global motor development delay, speech delay, intellectual disability, hypotonia and a history of seizures. CAPZA2 encodes a subunit of an F-actin-capping protein complex (CapZ). CapZ is an obligate heterodimer consisting of α and β heterodimer conserved from yeast to human. Vertebrate genomes contain three α subunits encoded by three different genes and CAPZA2 encodes the α2 subunit. The single orthologue of CAPZA genes in Drosophila is cpa. Loss of cpa leads to lethality in early development and expression of the human reference; CAPZA2 rescues this lethality. However, the two CAPZA2 variants identified in the probands rescue this lethality at lower efficiency than the reference. Moreover, expression of the CAPZA2 variants affects bristle morphogenesis, a process that requires extensive actin polymerization and bundling during development. Taken together, our findings suggest that variants in CAPZA2 lead to a non-syndromic neurodevelopmental disorder in children.
Control and Monitoring Differentiated Service Code Point in Two-Way Active Measurement Protocol (TWAMP) (2016)

This document describes an optional extension for Two-Way Active
Measurement Protocol (TWAMP) allowing control and monitoring of the
Differentiated Service Code Point (DSCP) field in forward and reverse
directions within single test session with the TWAMP-Test protocol.
This document, if accepted, will be an update to the TWAMP core
protocol specified in RFC 5357 and DSCP Monitoring mode defined in RFC
7750 .
Long-period ordering in a TiAl single crystal with a gradient composition (2005)

A series of long-period superstructures (LPSs) formed in an Al-rich TiAl single crystal with a gradient composition has been observed by transmission electron microscopy. A Ti–54.7 at.% Al single crystal was heat treated within molten Al at 1234°C, and a composition-gradient layer with an Al concentration from 55 to 75 at.% was formed at the surface of the single crystal. The composition-gradient layer exhibits ordering into different LPSs depending on the Al concentration as follows: short-range order, h-Al2Ti and one-dimensional antiphase domain structure. These LPSs have an alternate stacking of Al(002) and Ti–Al(002) layers and the ordering of the LPSs proceeds in the TiAl matrix, maintaining an orientation relationship in which Al(002) layers of the LPSs and the TiAl matrix are parallel to each other. The ordering of this type of LPS and the phase transition between these LPSs are thus interpreted as structural changes in Ti(002) layers of the Al-rich TiAl crystal. It was also observed that ordering of the orthorhombic h-Al2Ti exhibits anisotropic features depending on the direction of the composition gradient. This suggests that the long-period ordering in the TiAl crystal depends on diffusion processes as well as the local concentrations of Ti and Al atoms.
Extradigital Symplastic Glomus Tumor of the Hand (2014)

Glomus tumor is a rather common tumor of the hand, which presents with a classic triad of symptoms of high temperature, sensitivity and pain, and localized tenderness. Most glomus tumors are located in the digits, especially in subungueal areas. However, extradigital tumors are less frequent, and little is known about their clinical and histopathological features. Two cases of extradigital symplastic glomus tumor are presented. An active clinical and pathological awareness to avoid misdiagnosis or delayed diagnosis of this uncommon lesion is highlighted.
Supplementary Figure 3 from Locally Delivered CD40 Agonist Antibody Accumulates in Secondary Lymphoid Organs and Eradicates Experimental Disseminated Bladder Cancer (2023)

&lt;p&gt;PDF file - 195K, Figure 3. In vivo biodistribution of target organs 48h and 72h post injection of 125I-CD40-specific and 131I-rat IgG2a control antibody.&lt;/p&gt;
Small-Signal Stability-Constrained Optimal Power Flow for Inverter Dominant Autonomous Microgrids (2021)

This article details and solves a small-signal stability-constrained optimal power flow (SSSC-OPF) for inverter-based ac microgrids. To ensure a sufficient stability margin during optimal generation, a small-signal stability constraint is embedded into the conventional OPF formulation. This condition is enforced using a Lyapunov stability equation. A reduced-order model of the microgrid is adopted to alleviate the computational burden involved in solving the resulting SSSC-OPF. Even then, the resulting stability conditions are highly nonlinear and cannot be handled using the existing methods. To tackle the nonconvexity in the SSSC-OPF due to the presence of the nonlinear stability constraint, two distinct convex relaxation approaches, namely semidefinite programming and parabolic relaxations, are developed. A heuristic penalty function is added to the objective function of the relaxed SSSC-OPF, which is solved sequentially to obtain a feasible point. While off-the-shelf tools fail to produce any feasible point within hours, the proposed approach enables us to solve the SSSC-OPF in near real time. The efficacy of the proposed SSSC-OPF is evaluated by performing numerical studies on multiple benchmarks as well as real-time studies on a microgrid system built in a controller/hardware-in-the-loop setup.