gebhart/patrepeval huggingface dataset:
Reactions of benzylidene pentacarbonyltungsten with alkenes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of benzylidene pentacarbonyltungsten with alkenesCharles P. Casey, Stanley W. Polichnowski, Alan J. Shusterman, and Carol R. JonesCite this: J. Am. Chem. Soc. 1979, 101, 24, 7282–7292Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ja00518a025https://doi.org/10.1021/ja00518a025research-articleACS PublicationsRequest reuse permissionsArticle Views375Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
H2O2 Sensor Based on the Room-Temperature Phosphorescence of Nano TiO2/SiO2 Composite (2007)

A TiO2/SiO2 composite prepared by the sol-gel route can produce highly emissive broadband room-temperature phosphorescence at an excitation wavelength of 403 nm. The white phosphorescence of TiO2/SiO2 could be quenched by H2O2. The phosphorescence quenching effect demonstrated excellent sensitivity and high selectivity to H2O2. Furthermore, the phosphorescence of TiO2/SiO2 can be recovered when it is dipped in a hydroxylamine hydrochloride solution. Therefore, the TiO2/SiO2 was used to develop a reproducible phosphorescence sensor for H2O2. It has been successfully applied to the determination of H2O2 in the enzymatic catalytic reaction and real samples.
Spatial characterization of indoor radio channel measurements at 5 GHz (2002)

Multiple transmitters and receivers can be used to provide high link capacity in future wireless systems. Herein analysis of real indoor environment multiple-input-multiple-output measurements on the 5.8 GHz band is performed. The possible increase in capacity, utilizing multiple transmit and receive elements is examined. The gain possible when using channel knowledge at both transmitter and receiver is shown and the capacity dependence on the intra-element distance is examined for the experimental system and compared to simulations.
Competitive inhibition of folic acid absorption in rat jejunum by triamterene. (1986)

Triamterene, a diuretic agent, has been reported to cause megaloblastic anemia in some patients. Because this drug is a pteridine derivative, we investigated its effect on folic acid absorption in the rat jejunum. In an in vivo intestinal loop method, triamterene inhibited the intestinal absorption of folic acid in a dose-dependent fashion, with 50% inhibition of systemic absorption occurring at a luminal concentration of 0.01 mmol/L of triamterene. Kinetic analysis using the influx chamber method demonstrated that triamterene is a competitive inhibitor of intestinal folate transport, with a Ki of 0.125 mmol/L. Because therapeutic doses can result in luminal concentration of the drug approximating or exceeding the Ki, the interaction between triamterene and folate absorption is potentially of clinical interest.
ChemInform Abstract: THE CHEMISTRY OF CARBANIONS PART 27, A CONVENIENT PRECURSOR FOR THE GENERATION OF LITHIUM ORGANOCUPRATES (1975)

Abstract Der Komplex (I) ist in Dimethylsulfid und Äthem löslich und kann gut zur Herstellung der Lithium‐cuprate (II) und (III) eingesetzt werden.
SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization (2000)

Activation of the serine/threonine kinase Akt and the regulation of its activation are recognized as critical in controlling proliferative/survival signals via many hematopoietic receptors. In B lymphocytes, the B-cell receptor (BCR)-mediated activation of Akt is attenuated by co–cross-linking of BCR with the inhibitory receptor FcγRIIB1, and the binding of the SH2 domain-containing inositol phosphatase, SHIP, to FcγRIIB1. Because SHIP dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) and activation of Akt requires PIP3, the destruction of this phospholipid has been proposed as the mechanism for Akt inhibition. However, upstream kinases that activate Akt, such as PDK1, also require PIP3 for activation. In this report, we addressed whether SHIP inhibits Akt directly at the level of Akt recruitment to the membrane, indirectly through PDK recruitment/phosphorylation of Akt, or both. We generated stable B-cell lines expressing a regulatable, but constitutively membrane-bound Akt that still required PDK-dependent phosphorylation for activation. Several lines of evidence suggested that activation of this membrane-targeted Akt is not inhibited by FcγRIIB1/SHIP and that PDK is not a target for SHIP-mediated inhibition. These data demonstrate that SHIP inhibits Akt primarily through regulation of Akt membrane localization. We also observed during these studies that FcγRIIB1/SHIP does not inhibit p70S6k activation, even though several other PIP3-dependent events were down-regulated. Because the enhanced activation of Akt in the absence of SHIP correlates with hyperproliferation in the myeloid lineage, our data have implications for SHIP and Akt-dependent regulation of proliferation in the hematopoietic lineage.
Fixed-Exit Monochromators for High-Energy Synchrotron Radiation (1995)

Current developments in X-ray optics for synchrotron radiation beamlines are briefly reviewed. Reference is made to recent work on adaptive mirrors, cryogenic cooling of monochromators, use of thin diamond crystals, and active correction of the crystal shape for distortions caused by beam heating. The use of bent Si crystals as monochromators is discussed in detail. At high energies Si crystals become transparent to X-rays allowing new monochromator constructions. Bending of the crystal increases the energy bandpass and allows focusing. Different combinations of bent crystals that provide a fixed exit beam are discussed. These include vertically diffracting meridionally focusing Laue-Laue crystals, a Laue crystal combined with a sagittally focusing Bragg crystal, and a Laue-Bragg pair of crystals which provides meridional focusing at two stages.
Effect of Alumina Buffers on the Stability of Top-Gate Amorphous InGaZnO Thin-Film Transistors on Flexible Substrates (2015)

Flexible top-gate amorphous InGaZnO thin-film transistors are fabricated on polyimide substrates. The effect of the alumina buffer layers on the device performance and stability is demonstrated using two types of atomic layer deposition reactant sources: 1) ozone and 2) water. Alumina buffers formed by water reactants have better barrier properties against the ambient than those formed by ozone. Furthermore, less charge trapping at sub-gap density-of-states occurs with higher film density of the buffer layer. Stability characteristics under negative bias temperature stress are enhanced by optimization of the buffer layer formation on flexible substrates.
Natalizumab Therapy for Moderate to Severe Crohn Disease in Adolescents (2007)

Natalizumab (3 mg/kg) was well tolerated in these adolescent patients with active CD, with a safety and efficacy profile similar to that of adult natalizumab-treated CD patients. Future studies should evaluate long-term safety and efficacy.
Second Planck Catalogue of Compact Sources (PCCS2) (2017)

3 - prodotto gia presente in altro archivio Open Access, es. VizieR (allegare file read.me al passo 5-Carica)
Patterning of Surfaces by Oxidation of Amine‐Containing Compounds Using Scanning Electrochemical Microscopy (2009)

Ein Verfahren zur Herstellung von Mikromustern, das auf der Oxidation eines Amins beruht, beginnt mit der Reduktion einer nitrohaltigen Verbindung an der Spitze eines elektrochemischen Mikroskops (siehe Bild). Nach der Diffusion in der Lücke zwischen den Elektroden wird das Amin an einer Goldprobe oxidiert, was einer lokalen Derivatisierung entspricht. Dieses Verfahren sollte sich für die Erzeugung großer Mikrostrukturen auf Oberflächen eignen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Catalytic epoxidation of propene with H2O–O2reactants on Au/TiO2 (2008)

Au/TiO2catalysts form hydroperoxy species from H2O–O2 mixtures at near-ambient temperatures; these species can be used in the selective epoxidation of propene to propylene oxide.
Forced enhancer-promoter rewiring to alter gene expression in animal models (2023)

Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (<i>HBG</i>) and adult-type (<i>HBB</i>) β-globin genes during corresponding developmental stages. We have demonstrated previously that forcing proximity between the LCR and <i>HBG</i> genes in cultured adult-stage erythroid cells can activate <i>HBG</i> transcription. Activation of <i>HBG</i> expression in erythroid cells is of benefit to patients with sickle cell disease. Here, using the β-globin locus as a model, we provide proof of concept at the organismal level that forced enhancer rewiring might present a strategy to alter gene expression for therapeutic purposes. Hematopoietic stem and progenitor cells (HSPCs) from mice bearing human β-globin genes were transduced with lentiviral vectors expressing a synthetic transcription factor (ZF-Ldb1) that fosters LCR-<i>HBG</i> contacts. When engrafted into host animals, HSPCs gave rise to adult-type erythroid cells with elevated <i>HBG</i> expression. Vectors containing ZF-Ldb1 were optimized for activity in cultured human and rhesus macaque erythroid cells. Upon transplantation into rhesus macaques, erythroid cells from HSPCs expressing ZF-Ldb1 displayed elevated <i>HBG</i> production. These findings in two animal models suggest that forced redirection of gene-regulatory elements may be used to alter gene expression to treat disease.
Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection (2020)

Excitatory glutamatergic input mediating inspiratory drive to phrenic motor neurons (PhMNs) emanates primarily from the ipsilateral ventrolateral medulla. Unilateral C2 hemisection (C2SH) disrupts this excitatory input, resulting in cessation of inspiratory-related diaphragm muscle (DIAm) activity. In contrast, after C2SH, higher force, non-ventilatory DIAm activity persists. Inspiratory behaviours require recruitment of only smaller PhMNs, whereas with more forceful expulsive/straining behaviours, larger PhMNs are recruited. Accordingly, we hypothesize that C2SH primarily disrupts glutamatergic synaptic inputs to smaller PhMNs, whereas glutamatergic synaptic inputs to larger PhMNs are preserved. We examined changes in glutamatergic presynaptic input onto retrogradely labelled PhMNs using immunohistochemistry for VGLUT1 and VGLUT2. We found that 7 days after C2SH there was an ∼60% reduction in glutamatergic inputs to smaller PhMNs compared with an ∼35% reduction at larger PhMNs. These results are consistent with a more pronounced impact of C2SH on inspiratory behaviours of the DIAm, and the preservation of higher force behaviours after C2SH. These results indicate that the source of glutamatergic synaptic input to PhMNs varies depending on motor neuron size and reflects different functional control - perhaps separate central pattern generator and premotor circuits. For smaller PhMNs, the central pattern generator for inspiration is located in the pre-Bötzinger complex and premotor neurons in the ventrolateral medulla, sending predominantly ipsilateral projections via the dorsolateral funiculus. C2SH disrupts this glutamatergic input. For larger PhMNs, a large proportion of excitatory inputs appear to exist below the C2 level or from contralateral regions of the brainstem and spinal cord.
Repair-Optimal MDS Array Codes over GF(2) (2013)

Maximum-distance separable (MDS) array codes with high rate and an optimal repair property were introduced recently. These codes could be applied in distributed storage systems, where they minimize the communication and disk access required for the recovery of failed nodes. However, the encoding and decoding algorithms of the proposed codes use arithmetic over finite fields of order greater than 2, which could result in a complex implementation. In this work, we present a construction of 2-parity MDS array codes, that allow for optimal repair of a failed information node using XOR operations only. The reduction of the field order is achieved by allowing more parity bits to be updated when a single information bit is being changed by the user.
Grainyhead‐like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety‐like behaviors in aged mice (2016)

The highly conserved Grainyhead-like (Grhl) family of transcription factors, comprising three members in vertebrates (Grhl1-3), play critical regulatory roles during embryonic development, cellular proliferation, and apoptosis. Although loss of Grhl function leads to multiple neural abnormalities in numerous animal models, a comprehensive analysis of Grhl expression and function in the mammalian brain has not been reported. Here they show that only Grhl3 expression is detectable in the embryonic mouse brain; particularly within the habenula, an organ known to modulate repressive behaviors. Using both Grhl3-knockout mice (Grhl3<sup>-/-</sup> ), and brain-specific conditional deletion of Grhl3 in adult mice (Nestin-Cre/Grhl3<sup>flox/flox</sup> ), they performed histological expression analyses and behavioral tests to assess long-term effects of Grhl3 loss on motor co-ordination, spatial memory, anxiety, and stress. They found that complete deletion of Grhl3 did not lead to noticeable structural or cell-intrinsic defects in the embryonic brain; however, aged Grhl3 conditional knockout (cKO) mice showed enlarged lateral ventricles and displayed marked changes in motor function and behaviors suggestive of decreased fear and anxiety. They conclude that loss of Grhl3 in the brain leads to significant alterations in locomotor activity and decreased self-inhibition, and as such, these mice may serve as a novel model of human conditions of impulsive behavior or hyperactivity. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 775-788, 2017.
A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation (2022)

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis. However, alternative splicing regulation during this process remains understudied. Using transcriptomic data from human, mouse, and cow preimplantation development, we show that the stage of zygotic genome activation (ZGA) exhibits the highest levels of exon skipping diversity reported for any cell or tissue type. Much of this exon skipping is temporary, leads to disruptive noncanonical isoforms, and occurs in genes enriched for DNA damage response in the three species. Two core spliceosomal components, <i>Snrpb</i> and <i>Snrpd2</i>, regulate these patterns. These genes have low maternal expression at ZGA and increase sharply thereafter. Microinjection of <i>Snrpb/d2</i> messenger RNA into mouse zygotes reduces the levels of exon skipping at ZGA and leads to increased p53-mediated DNA damage response. We propose that mammalian embryos undergo an evolutionarily conserved, developmentally programmed splicing failure at ZGA that contributes to the attenuation of cellular responses to DNA damage.
Impact Finite-Element Analysis of Slip-Base Sign Support Mechanism (2000)

The slip-base design mechanism is used to support signs and luminaries in highways and is designed to break away in crashes with vehicles. This mechanism is intended to minimize occupant injuries by providing reduced resistance to the impacting vehicles. The slip-base mechanism could be sensitive to many design parameters. Conventional design and evaluation of safety performance of these systems by trial and error and crash testing is inefficient, as well as cost prohibitive. Therefore, finite-element (FE) models that can accurately simulate the performance of the slip-base system in various crash scenarios are of essential value. This paper describes dynamic FE models of a slip-base sign support system and its crash performance with vehicles using DYNA3D code. The geometric features, as well as several physical phenomena of components of the slip-base mechanism, e.g., sliding friction, clamping forces, bolt-plate interactions, and plate rupture, are modeled and verified in simulation. The FE modeling methods for the required features are described in detail. A validated model of Bogie and its honeycomb material is used as the impacting vehicle. FE crash simulations of Bogie with flexible honeycomb nose impacting the slip-base sign support are validated using the corresponding instrumented crash tests. The simulation model reveals the correct behavior of the break away system response upon impact. The slipping mechanism and Bogie acceleration and velocity responses are accurate as compared with actual crash test results. The FE approach and this validated model can be exercised in numerous crash scenarios for design optimization of other variations of slip-base systems in size, orientation, etc., or for performance evaluation of impacts with various vehicles.
Substituent Effect on Reaction of p-Substituted Phenylalkylsilylamines with β-Propiolactone (1970)

p-位に置換基を有するフェニルジメチルシリルジエチルアミンによるβ-プロピオラクトンの開環反応の速度論的研究を, 赤外吸収スペクトル分析法を用いて行なった。四種のp-置換 (H, Cl, Me, MeO) フェニルジメチルシリルジエチルアミンの反応にはいずれも二次速度式が適用でき, かつ反応速度は置換基の電子供与性の増大とともに大きくなることを認めた。上記四種の置換基に関するハメットの反応定数を求め ρ=-0.4 を得た。アリルアルキルシリルアミンが対応するトリメチルシリルアミンに比し大きな反応性を有する説明は, Ar-Si-N 結合における cross-conjugation 効果で予想できるものと良く一致した。
Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects (2020)

Excitotoxicity seems to play a critical role in ocular neurodegeneration. Excess-glutamate-mediated retinal ganglion cells death is the principal cause of cell loss. Uncontrolled glutamate in the synapsis has significant implications in the pathogenesis of neurodegenerative disorders. The exploitation of various approaches of controlled release systems enhances the pharmacokinetic and pharmacodynamic activity of drugs. In particular, microparticles are secure, can maintain therapeutic drug concentrations in the eye for prolonged periods, and make intimate contact by improving drug bioavailability. According to the promising results reported, possible new investigations will focus intense attention on microparticulate formulations and can be expected to open the field to new alternatives for doctors, as currently required by patients.
Modified Gene Editing Systems: Diverse Bioengineering Tools and Crop Improvement (2022)

Gene-editing systems have emerged as bioengineering tools in recent years. Classical gene-editing systems include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9), and these tools allow specific sequences to be targeted and edited. Various modified gene-editing systems have been established based on classical gene-editing systems. Base editors (BEs) can accurately carry out base substitution on target sequences, while prime editors (PEs) can replace or insert sequences. CRISPR systems targeting mitochondrial genomes and RNA have also been explored and established. Multiple gene-editing techniques based on CRISPR/Cas9 have been established and applied to genome engineering. Modified gene-editing systems also make transgene-free plants more readily available. In this review, we discuss the modifications made to gene-editing systems in recent years and summarize the capabilities, deficiencies, and applications of these modified gene-editing systems. Finally, we discuss the future developmental direction and challenges of modified gene-editing systems.
The data acquisition and calibration system for the ATLAS Semiconductor Tracker (2008)

The SemiConductor Tracker (SCT) data acquisition (DAQ) system will calibrate, configure, and control the approximately six million front-end channels of the ATLAS silicon strip detector. It will provide a synchronized bunch-crossing clock to the front-end modules, communicate first-level triggers to the front-end chips, and transfer information about hit strips to the ATLAS high-level trigger system. The system has been used extensively for calibration and quality assurance during SCT barrel and endcap assembly and for performance confirmation tests after transport of the barrels and endcaps to CERN. Operating in data-taking mode, the DAQ has recorded nearly twenty million synchronously-triggered events during commissioning tests including almost a million cosmic ray triggered events. In this paper we describe the components of the data acquisition system, discuss its operation in calibration and data-taking modes and present some detector performance results from these tests.
Structural characterization of base/collector interfaces for magnetic tunnel transistors grown on Si(001) (2005)

The microstructure and composition of magnetic tunnel transistors (MTTs), grown on Si(001) collector substrates, have been investigated using high-resolution and analytical electron microscopy. The effects of different seed layers, including a ferromagnetic metal Fe, and noble metals Pd, Ir, Re, and Ru, on the tunnel junction morphology were studied. The Pd seed layers reacted with the Si substrate, and gave MTTs with a small transfer ratio and relatively large leakage current. Devices based on Ir and Re seed layers invariably shorted out, as did most of those with Ru seed layers. Very thin Fe seed layers gave flat and more abrupt seed-layer/Si substrate interfaces, and among the samples studied, the best transport properties were achieved for a thin Fe seed layer in combination with Co70Fe30 base layer.