gebhart/patrepeval huggingface dataset:
Errors in ultrasonographic measurements of the kidney (2000)

During each sonographic examination the following medulla ( Figure 2a and2b).This measurement should not be performed at the upper and lower poles, but in measurements should be obtained: maximal length and parenchymal border width-this measurement should the middle third of the kidney.The section should be perpendicular to the renal surface (avoid sections in be done in longitudinal section.Also the comparison of both parameters between the right and the left an oblique plane).Measurements should be made with the patient in kidney should be carried out and if possible a comparison with previous measurements, should be made.side position, and here with the transducer from dorsal direction; examinations in supine position or from ventral cause false low values because the parenchymal
802.16 and WiMAX (2006)

This chapter contains sections titled: Overview Standards, Evolution, and Profiles WiMAX PHYs for Point-to-Multipoint FDD or TDD Operation Physical Layer Framing Ensuring Quality of Service MAC Management Functions MAC Management of User Data Security Advanced 802.16 Functionalities Mobile WiMAX: 802.16e WiMAX Network Infrastructure Comparison of 802.16 with UMTS, HSDPA, and WLAN Questions References
Inhibition of cytochrome P450 3A by acetoxylated analogues of resveratrol in in vitro and in silico models (2016)

Many dietary compounds, including resveratrol, are potent inhibitors of CYP3A4. Here we examined the potential to predict inhibition capacity of dietary polyphenolics using an in silico and in vitro approaches and synthetic model compounds. Mono, di, and tri-acetoxy resveratrol were synthesized, a cell line of human intestine origin and microsomes from rat liver served to determine their in vitro inhibition of CYP3A4, and compared to that of resveratrol. Docking simulation served to predict the affinity of the synthetic model compounds to the enzyme. Modelling of the enzyme's binding site revealed three types of interaction: hydrophobic, electrostatic and H-bonding. The simulation revealed that each of the examined acetylations of resveratrol led to the loss of important interactions of all types. Tri-acetoxy resveratrol was the weakest inhibitor in vitro despite being the more lipophilic and having the highest affinity for the binding site. The simulation demonstrated exclusion of all interactions between tri-acetoxy resveratrol and the heme due to distal binding, highlighting the complexity of the CYP3A4 binding site, which may allow simultaneous accommodation of two molecules. Finally, the use of computational modelling may serve as a quick predictive tool to identify potential harmful interactions between dietary compounds and prescribed drugs.
Amdahl's law for tail latency (2018)

Queueing theoretic models can guide design trade-offs in systems targeting tail latency, not just average performance.
How to determine cost savings for a records/files management program. (1983)

This article provides some guidelines for distinguishing between feelings and facts in order to determine the cost savings potential for a particular system, first to convince oneself of the "rightness" of the new approach and second, to convince other decision makers in the organization of the true benefits, including economic benefits of the change.
Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. (1989)

A cDNA coding for histatin 1 was isolated from a human submandibular-gland library and sequenced. This cDNA was used to probe RNAs isolated from a variety of tissues to investigate tissue-specific regulation and to determine whether histatins might play a role other than in the oral cavity. The same probe was also used for Southern blot analysis of human genomic DNA restricted with various enzymes, and it showed that the genes coding for histatins are on the same chromosome. In situ hybridization of the cDNA probe to metaphase chromosome spreads was performed to determine chromosomal location of the genes for histatins. A genomic fragment isolated using the cDNA probe was also hybridized to chromosome spreads, and the same chromosome was identified. The genes for histatins are located on chromosome 4, band q13. We have shown that three histatin mRNAs are expressed in human parotid and submandibular glands but in none of the other tissues studied. These results suggest that histatins are specific to salivary secretions.
ACES: Propulsion Technology for next Generation Space Transportation (2003)

Andrews Space has developed the “Alchemist” Air Collection and Enrichment System (ACES), a dualmode propulsion system that enables safe, economical launch systems that take off and land horizontally. Alchemist generates liquid oxygen through separation of atmospheric air using the refrigeration capacity of liquid hydrogen. The key benefit of Alchemist is that it minimizes vehicle takeoff weight. All internal and NASA-funded activities have shown that ACES, previously proposed for hypersonic combined cycle RLVs, is a higher payoff, lower-risk technology if LOX generation is performed while the vehicle cruises subsonically.
Capacity in Dense Ad Hoc Networks (2004)

Abstrad-We study the connectivity and capacity of tinite ares ad hoc wireless networks, with an increasing number of nodes (dense networks). We find that the properties of the network stmngly depend on the shape of the attenuation function. For power law attenuation functions, connectivity scales, and the availahle rate per node is known to decrease like I/,,%. On the contrary, if the attenuation function does not have a singularity at the origin and is nnifiwrnly hounded. we irhtain hounds on the percolation domain for large node densities, which show that either the network heconies dkonnected, or the available rate per node decreases like l/n.
Phase I study of patients with non-muscle invasive bladder cancer (NMIBC) treated with vesigenurtacel-L (HS-410) after Bacillus Calmette-Guérin (BCG) (2015)

Meeting abstracts Vesigenurtacel-L (HS-410), consists of an allogeneic bladder cancer cell line, selected for high expression of a series of tumor antigens that are known to be shared by a high proportion of bladder tumors. The cell line secretes gp96-Ig, a modified heat shock protein which
GaAs/AlGaAs grating surface-emitting diode lasers on Si substrates (1989)

A monolithic grating surface-emitting, GaAs/AlGaAs, separate-confinement-heterostructure, single-quantum-well diode laser has been fabricated on a Si substrate using a single-step metalorganic chemical vapour deposition process. An output power of 30 mW has been obtained under pulsed operation with a peak emission wavelength of 885 nm.
ChemInform Abstract: REACTION BETWEEN VICINAL DIOLS AND HYDROGEN BROMIDE IN ACETIC ACID, SYNTHESIS OF CHIRAL PROPYLENE OXIDE (1973)

Abstract Die Bildung von Acetoxybromiden durch Reaktion der Diole (I) mit HBr/Essigsäure verläuft über das 1,3‐Dioxolanylium‐(2)‐Ion.
Preformed class II donor-specific antibodies are associated with an increased risk of early rejection after liver transplantation (2013)

Preformed donor-specific human leukocyte antigen antibodies (DSAs) are considered a contraindication to the transplantation of most solid organs other than the liver. Conflicting data currently exist on the importance of preformed DSAs in rejection and patient survival after liver transplantation (LT). To evaluate preformed DSAs in LT, we retrospectively analyzed prospectively collected samples from all adult recipients of primary LT without another organ from January 1, 2000 to May 31, 2009 with a pre-LT sample available (95.8% of the patients). Fourteen percent of the patients had preformed class I and/or II DSAs with a mean fluorescence intensity (MFI) ≥ 5000. Preformed class I DSAs with an MFI ≥ 5000 remained persistent in only 5% of patients and were not associated with rejection. Preformed class II DSAs with an MFI of 5000 to 10,000 remained persistent in 23% of patients, and this rate increased to 33% for patients whose MFI was ≥10,000 (P < 0.001). Preformed class II DSAs in multivariable Cox proportional hazards modeling were associated with an increased risk of early rejection [hazard ratio (HR) = 1.58; p = 0.004]. In addition, multivariate modeling showed that in comparison with no DSAs (MFI < 1000), preformed class I and/or II DSAs with an MFI ≥ 5000 were independently correlated with the risk of death (HR = 1.51; p = 0.02).
Control of non-linear elasticity in F-actin networks with microtubules (2010)

We measure the elastic properties of composite cytoskeletal networks consisting of cross-linked actin filaments and microtubules. We show that even a small concentration of microtubules leads to dramatic and qualitative changes in the non-linear elastic properties of the actin filament networks. Specifically, we find that microtubules promote non-linear stiffening of F-actin networks because they are much stiffer than actin filaments and therefore suppress non-uniform strain. This finding may be relevant for interpretation of the mechanical behavior of cells, while also suggesting a new way to reinforce the non-linear elasticity of semiflexible polymer materials.
Investigations into Thermally Mediated Drug Delivery Using a Preclinical System for MRI-Guided Focused Ultrasound (2011)

The objective of this research was to investigate the use of a preclinical system for MRI‐guided focused ultrasound to achieve MRI‐controlled hyperthermia and thermally‐mediated drug delivery in vivo. Here we report results from ten rabbits, where a focused ultrasound (FUS) beam was scanned in a circular trajectory to heat 10–15 mm diameter regions in normal thigh to 43 °C for 20–30 minutes. MRI thermometry was used for closed‐loop feedback control to achieve temporally and spatially uniform heating. Lyso‐thermosensitive pegylated liposomal doxorubicin (ThermoDox®, Celsion Corporation, Columbia, MD) was infused intravenously during hyperthermia, and the tissue doxorubicin concentration was measured by the fluorescence intensity of homogenized tissue samples from heated and unheated thigh, obtained 2 hours after heating. Closed‐loop control of FUS hyperthermia using MRI thermometry achieved temperature distributions with mean, T90 and T10 of 42.9 °C, 41.0 °C and 44.8 °C across the 10 mm diameter target, varying ±0.9 °C (SD) over 20 min. Drug concentrations in heated regions were, on average 15.3±8.1 (SD) times higher than in the unheated contralateral thigh. The results show the feasibility of using MRI‐controlled FUS hyperthermia for preclinical studies of thermally mediated drug delivery with temperature‐sensitive liposomes.
Local structure analysis of Sb, Bi, and Ag dopant atoms in Mg2Si semiconductor by x-ray absorption spectroscopy and first-principles calculation (2021)

The local structures around Sb, Bi, and Ag dopant atoms in the environmentally friendly semiconductor Mg2Si were investigated by Sb K-edge, Bi L3-edge, and Ag K-edge x-ray absorption spectroscopy performed at 10 K. Fourier transforms (FTs) of the k3-weighted extended x-ray absorption fine structure (EXAFS) were analyzed. The experimental FTs of k3-weighted EXAFS were compared with the results of calculations using model clusters with Sb, Bi, and Ag atoms at the 8c, 4a, and 4b sites. The inverse FT of the χ(R) spectrum was calculated to refine the local structures for neighboring atoms around the Sb, Bi, and Ag atoms, and the interatomic distances and Debye–Waller factors were determined from the fit of the inverse FTs. The occupation of the 4a site by Sb and Bi atoms was demonstrated and that of the 8c site was investigated for Ag atoms. First-principles calculations were performed to clarify the characteristic change in the second-neighbor distances around the Ag atoms. The evaluation of the crystal orbital Hamilton population clarified that the change in the second-neighbor distances is caused by the bonding character formed between the Ag and Mg atoms. These results suggest that the Ag atoms mainly occupy the 8c site, while the large value of the Debye–Waller factor for the second neighboring atoms implies the possibility of the partial occupation of Ag atoms at the 4b sites. These findings provide an explanation for limiting the p-type conductivity in Mg2Si semiconductors.
Design of Privacy-Preserving Cloud Storage Framework (2010)

Privacy security is a key issue for cloud storage. To solve this problem, the paper proposes a privacy-preserving cloud storage framework, which includes the design of data organization structure, the generation and management of keys, the treatment of change of users' access right and dynamic operations of data, and the interaction between participants. We design an interactive protocol and an extirpation-based key derivation algorithm, which are combined with lazy revocation, multi-tree structure and symmetric encryption to form a privacy-preserving, efficient framework for cloud storage. A system is realized which is based on the framework. The paper analyzes the effectiveness of extirpation-based key derivation algorithm, the overhead of the system and the privacy security of the framework. Finally, we summarize our work and introduce our future research directions.
Influence of Distillers Dried Grain Supplementation Frequency on Forage Digestibility and Growth Performance of Beef Cattle (2009)

Three experiments evaluated the influence of supplementation frequency of distillers dried grains plus solubles (DDGS) on forage digestibility (Exp. 1) and growth of yearling heifers (Exp. 2) and steers (Exp. 3). In Exp. 1, 6 steers (371 ± 30 kg) were used in a replicated 3 × 3 Latin square design with three 21-d periods. Treatments were DDGS fed at 16.7% of the diet (DM) either 1) daily, 2) every other day, or 3) every third day. In Exp. 2, 48 heifers (193 ± 20 kg) were fed hay and supplemented with the daily equivalent of 1.3 kg/heifer of DDGS, either 3 or 6 d/wk. In Exp. 3, 48 steers were assigned to replicated supplementation groups. Treatments were 1) hay and supplement fed 6 d/wk in a dry lot (control); 2) native winter range and supplement fed 6 d/wk; 3) native winter range and a DDGS supplement fed 6 d/wk; and 4) native winter range and the same DDGS supplement fed 3 d/wk. In Exp. 1, diet DM (P = 0.06), OM (P = 0.07), and hay NDF (P = 0.03) digestibility decreased linearly as DDGS supplementation frequency decreased. In Exp. 2, heifers fed DDGS 6 d/wk gained more BW (P = 0.01) than heifers fed 3 d/wk. In Exp. 3, steers fed the control diet, native winter range and supplement fed 6 d/wk, and native winter range and DDGS supplement fed 6 d/wk performed similarly, but performance was decreased when steers were fed native winter range and the DDGS supplement 3 d/wk. Improved animal growth may result from more frequent supplementation of DDGS when fed in excess of 15% of the diet.
Racial and Family Experience Correlates of Mobility Aspiration (1962)

THE PROBLEM The concept of the Achievement Syndrome as a psychocultural variable essential to any consideration of social mobility has been introduced into the literature by Rosen (16, 17). Rosen's work reflects a heightened concern during the last decade with developing quantitative approaches to this problem area. The present study is an investigation of mobility aspiration making use of the quantitative techniques employed by Rosen and by Dynes, Clarke, and Dinitz (6).
Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells (2003)

Insulin resistance as well as pancreatic beta-cell failure can be induced by elevated free fatty acid (FFA) levels. We studied the mechanisms of FFA-induced apoptosis in rat and human beta-cells. Chronic treatment with high physiological levels of saturated fatty acids (palmitate and stearate), but not with monounsaturated (palmitoleate and oleate) or polyunsaturated fatty acids (linoleate), triggers apoptosis in approximately 20% of cultured RIN1046-38 cells. Apoptosis restricted to saturated FFAs was also observed in primary cultured human beta-cells, suggesting that this mechanism is potentially relevant in vivo in humans. To further analyze FFA-induced signaling pathways leading to apoptosis, we used RIN1046-38 cells. Apoptosis was accompanied by a rapid (within 15 min) nuclear translocation of protein kinase C (PKC)-delta and subsequent lamin B1 disassembly. This translocation was impaired by the phospholipase C inhibitor U-73122, which also substantially reduced apoptosis. Furthermore, lamin B1 disassembly and apoptosis were decreased by cell transfection with a dominant-negative mutant form of PKC-delta. These data suggest that nuclear translocation and kinase activity of PKC-delta are both necessary for saturated fatty acid-induced apoptosis.
Inhibition of respiratory syncytial virus by RhoA-derived peptides: implications for the development of improved antiviral agents targeting heparin-binding viruses (2004)

The respiratory syncytial virus (RSV) fusion glycoprotein (F) can interact with the small intracellular GTPase RhoA, and peptides derived from RhoA inhibit RSV replication. These observations initially suggested that RhoA-derived peptides might inhibit RSV replication by disrupting an in vivo interaction between RSV F and RhoA. However, recent data indicate that the antiviral activity of RhoA-derived peptides is not due to competitive inhibition of an hypothesized F-RhoA interaction, but is rather a function of the peptides' intrinsic biophysical properties. We summarize here what is known about the mechanism of RSV inhibition by these peptides and give our opinion regarding the potential implications of this work with regards to RSV biology, and to the development of antiviral agents targeting RSV and other enveloped viruses.
SPECIAL DEPARTMENTS (2000)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.1.235 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10623717 Jean-Pierre Pignon Michel DucreuxxJean-Pierre Pignon Michel DucreuxSearch for articles by this author , Philippe RougierxPhilippe RougierSearch for articles by this author Charles ErlichmanxCharles ErlichmanSearch for articles by this author Show More Institut Gustave-Roussy VillejuifFranceHôpital Ambroise-Paré BoulogneFranceOn behalf of the IMPACT B2 Investigators Mayo Clinic RochesterMN https://doi.org/10.1200/JCO.2000.18.1.235 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical OncologyjcoJ Clin OncolJournal of Clinical OncologyJCO0732-183X1527-7755American Society of Clinical OncologyResponse01012000In Reply:Pignon et al suggest that comparing the efficacy in stage II and III patients would have increased the power of our study. I refer them to the publication in the Lancet in 1995,1 in which a complete analysis of the total population was undertaken. In this publication, there was a statistically significant difference between the total populations treated with fluorouracil/leucovorin versus the controls and in the subset of stage III patients. At the time we did that analysis, there were insufficient events to allow an analysis of the stage II patients. The recent publication2 in the Journal of Clinical Oncology reflects the analysis when sufficient events had occurred, such that an analysis was appropriate.We could have updated the analysis for the whole population and then done a separate analysis for the stage II and III patients. However, this exercise would not have increased our power to address the question of whether fluorouracil and leucovorin had any benefit in patients with stage II colon cancer. The only way we can potentially increase the power of this study is to undertake another analysis with longer follow-up of the stage II subset. As far as the publication of the meta-analysis performed by the Colorectal Cancer Collaborative Group is concerned, it is not clear whether the question will be settled by such an analysis if there are multiple treatment regimens in which the chemotherapy is being used, which would make it more difficult to sort out whether fluorouracil/leucovorin, specifically, is useful in stage II colon cancer.3. The IMPACT Investigators: Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. Lancet 345::939,1995-944, Crossref, Medline, Google Scholar3. International Multicentre Pooled Analysis of B2 Colon Cancer Treatment (IMPACT B2) Investigators: Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. J Clin Oncol 17::1356,1999-1363, Link, Google Scholar
Light Field Otoscope (2014)

We introduce a light field otoscope that enables new functionalities for middle ear imaging, such as depth estimation, multi-view extraction, and multispectral rendering of the tympanic membrane. A prototype and experimental results are presented.
Photoluminescence from In0.3Ga0.7N/GaN multiple-quantum-well nanorods (2005)

The fabrication of In0.3Ga0.7N/Ga Nm ultiple-quantum-well nanorods with diameters of 60–100 nm and their optical characteristics performed by micro-photoluminescence measurements are presented. The nanorods were fabricated by inductively coupled plasma dry etching from a light-emitting diode wafer. The structure and surface properties of fabricated nanorods were verified by the field emission scanning electron microscopy and the transmission electron microscopy. The photoluminescence (PL) spectra with sharp linewidths of typically 1.5 nm were observed at 4 K. The excitation-power-dependent spectra show that no energy shift was observed for these sharp peaks. Moreover, increasing the excitation power instead leads to an occurrence of new, sharp PL peaks at the higher energy tail of the PL spectra, which suggest that excitons are strongly confined in quantum-dot-like regions or localization centres.
Topical application of fluorides on teeth (1993)

Prevention of caries in exposed root surfaces constitutes an important clinical problem. It is thus important that clinicians involved with periodontology have an insight into fluoride prophylaxis. The understanding of the cariostatic mechanism of fluoride has improved during recent years. The aim of the present review is to give a short account of the present concept. Calcium fluoride appears to be the only product which is formed on enamel, dentin or cementum during brief topical treatments with fluoride or use of toothpaste containing fluoride. This calcium fluoride is stable in the oral environment; this is contrary to what was believed until recently. The calcium fluoride constitutes a pH-dependent reservoir of fluoride which releases fluoride when pH drops. The practical consequences of this concept is discussed.
Application of Genetically Modified and Cloned Pigs in Translational Research (2009)

Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of genetically modified and cloned pigs in translational studies. It also highlights pigs specially designed as disease models, for xenotransplantation or to carry cell marker genes. Finally, use of porcine somatic stem and progenitor cells in preclinical studies of cell transplantation therapy is also discussed.