gebhart/patrepeval huggingface dataset:
Subcellular localisation of internally deleted HBV core proteins (2004)

Hepatitis B virus (HBV) variants with core internal deletions were isolated from renal graft recipients in whom an association with end stage liver disease was observed. The aim of this work was evaluation of intracellular localisation of these HBV core variants with internal deletions. Infection of baby hamster kidney cell culture BHC-21 C13 with recombinant Semliki Forest viruses encoding the deleted variant and undeleted wild type HBV core (HBc) genes led to the detection of HBc protein within the nucleus only in the case of deletion variants. Deleted HBc protein in all probability may be partially unfolded, hence unstable. As a consequence, deleted HBc proteins are not part of HBV nucleocapsids, but are left unassembled and are able to cross the nuclear membrane. We suggest that the presence of deleted HBc proteins within the cell nucleus may be of pathogenic importance.
Fed‐batch bioreactor performance and cell line stability evaluation of the artificial chromosome expression technology expressing an IgG1 in chinese hamster ovary cells (2010)

The artificial chromosome expression (ACE) technology system uses an engineered artificial chromosome containing multiple site-specific recombination acceptor sites for the rapid and efficient construction of stable cell lines. The construction of Chinese hamster ovary(CHO) cell lines expressing an IgG1 monoclonal antibody (MAb) using the ACE system has been previously described (Kennard et al., Biotechnol Bioeng. 2009;104:540-553). To further demonstrate the manufacturing feasibility of the ACE system, four CHO cell lines expressing the human IgG1 MAb 4A1 were evaluated in batch and fed-batch shake flasks and in a 2-L fed-batch bioreactor. The batch shake flasks achieved titers between 0.7 and 1.1 g/L, whereas the fed-batch shake flask process improved titers to 2.5–3.0 g/L. The lead 4A1 ACE cell line achieved titers of 4.0 g/L with an average specific productivity of 40 pg/(cell day) when cultured in a non optimized 2-L fed-batch bioreactor using a completely chemically defined process. Generational stability characterization of the lead 4A1-expressing cell line demonstrated that the cell line was stable for up to 75 days in culture. Product quality attributes of the 4A1 MAb produced by the ACE system during the stability evaluation period were unchanged and also comparable to existing expression technologies such as the CHO-dhfr system. The results of this evaluation demonstrate that a clonal, stable MAb-expressing CHO cell line can be produced using ACE technology that performs competitively using a chemically defined fed-batch bioreactor process with comparable product quality attributes to cell lines generated by existing technologies.
Wound healing in development (2012)

Wound healing is the inherent ability of an organism to protect itself against injuries. Cumulative evidence indicates that the healing process patterns in part embryonic morphogenesis and may result in either organ regeneration or scarring, phenomena that are developmental stage- or age-dependent. Skin is the largest organ. Its morphogenesis and repair mechanisms have been studied extensively due not only to its anatomical location, which allows easy access and observation, but also to its captivating structure and vital function. Thus, this review will focus on using skin as a model organ to illustrate new insights into the mechanisms of wound healing that are developmentally regulated in mammals, with special emphasis on the role of the Wnt signaling pathway and its crosstalk with TGF-β signaling. Relevant information from studies of other organs is discussed where it applies, and the clinical impact from such knowledge and emerging concepts on regenerative medicine are discussed in perspective.
Band Steering Technology Based on QoE-Oriented Optimization in Wireless Network (2020)

Abstract In mobile crowd-sensing (MCS) network, it is necessary to reduce the cost of sensing data transformation from mobile devices to the MCS platform in the core of the network. With the widespread deployment of access point (AP), explosive data traffic of the mobile devices is offloaded from cellular base stations to Wi-Fi networks. The congestion of the 2.4 GHz band in dual-band wireless area network makes the lower quality of experience (QoE) of users. To ease the load of 2.4 GHz band, the band-steering technology has been widely used by equipment manufacturers. However, the fixed threshold configuration strategy in band steering technology makes it easy to be exploited by setting up a great number of connection requirements in a short time, which may prevent a normal connection requirement of a user, making it difficult to satisfy the dynamic resource requirements of different services. Moreover, if the threshold is configured too high, it may result in QoE imbalance in dual bands. Besides, when the band (such as 2.4 GHz) resources cannot meet the terminal requirement, the terminal cannot autonomously switch to another band (such as 5 GHz), and this may result in a very poor QoE of users. In this paper, a secure QoE-oriented wireless network optimization framework is proposed to improve the QoE of users in dual-band network. Firstly, to ensure the overall QoE of network and balancing the QoE between 2.4 GHz and 5 GHz bands, the framework dynamically adjusts the load threshold of the frequency band based on QoE information during the association of a terminal. Secondly, to meet the basic QoE requirement of each user, the framework preferentially switches the terminals with poor QoE to the idle band after users join the network. The experimental results show that the proposed framework can improve the QoE both before and after the terminal accesses the network. Additionally, it enables the better QoE balance in dual bands.
<title>Fully automated optical lens design for automotive lighting</title> (1997)

Aerodynamic headlamp lenses have presented several challenges and opportunities to the Automotive lighting community in terms of Computer Aided Optical Design, Raytrace simulation, Visualization of end parts and communication of optics information to tool shops. This paper will examine existing practices of headlamp lens design and describe a new optics automation tool (FALCON) which effectively integrates design, simulation, visualization and optics manufacturing using IGES.1 It will conclude with the benefits of automating optical lens design.
Iodocyclization, Followed by Palladium-Catalyzed Coupling: A Versatile Strategy for Heterocyclic Library Construction (2012)

The iodocyclization of functionally-substituted alkynes provides an excellent way to prepare a wide range of iodoheterocycles, which can then be readily elaborated through palladium-catalyzed Suzuki-Miyaura, Sonogashira, Heck, Hartwig-Buchwald, and carbonylation processes into libraries of medicinally relevant heterocycles. The synthesis of libraries of indoles, benzofurans, benzothiophenes, isocoumarins and pyrones, cyclic imidates, isoxazoles, furans using this approach is reviewed. This technology is very versatile, proceeds under mild reaction conditions in high yields, and tolerates considerable functionality.
Pervasive Wireless Channel Modeling Theory and Applications to 6G GBSMs for All Frequency Bands and All Scenarios (2022)

In this paper, a pervasive wireless channel modeling theory is first proposed, which uses a unified channel modeling method and a unified equation of channel impulse response (CIR), and can integrate important channel characteristics at different frequency bands and scenarios. Then, we apply the proposed theory to a three dimensional (3D) space-time-frequency (STF) non-stationary geometry-based stochastic model (GBSM) for the sixth generation (6G) wireless communication systems. The proposed 6G pervasive channel model (6GPCM) can characterize statistical properties of channels at all frequency bands from sub-6 GHz to visible light communication (VLC) bands and all scenarios such as unmanned aerial vehicle (UAV), maritime, (ultra-)massive multiple-input multiple-output (MIMO), reconfigurable intelligent surface (RIS), and industry Internet of things (IIoT) scenarios. By adjusting channel model parameters, the 6GPCM can be reduced to various simplified channel models for specific frequency bands and scenarios. Also, it includes standard fifth generation (5G) channel models as special cases. In addition, key statistical properties of the proposed 6GPCM are derived, simulated, and verified by various channel measurement results, which clearly demonstrates its accuracy, pervasiveness, and applicability.
STEM-15. SMALL BUT FIERCE: THE ROLE OF EXTRACELLULAR VESICLES IN MESENCHYMAL TRANSITION AND THERAPEUTIC RESISTANCE IN GLIOBLASTOMA (2020)

Abstract Glioblastoma (GBM) is a dismal disease and despite optimal treatment, long-term survival remains uncommon. Molecular classification revealed three distinct GBM subgroups and has helped to shine light on the tumor’s inter/intratumoral heterogeneity. Interestingly, recent evidence shows plasticity between these subtypes in which the proneural (PN) glioma stem-like cells undergo transition into the more aggressive mesenchymal (MES) subtype leading to therapeutic resistance. Extracellular vesicles (EVs) are considered a heterogeneous group of membrane-limited vesicles secreted by nearly every cell. In the context of GBM, these biological nanoparticles act as multifunctional signaling complexes and play an important role in intercellular communication allowing cancer cells to exchange information with each other, the tumor microenvironment, and distant cells. We show that MES cells derived EVs modulate PN cells to increase migratory potential, stemness, invasiveness, aggressiveness, and therapeutic resistance by inducing mesenchymal transition through NF-KB/STAT3 signaling. Furthermore, we shine light on the role of EVs derived from irradiated GBM cells and their potential impact on microglia and resulting treatment resistance.
Variational Pose Prediction with Dynamic Sample Selection from Sparse Tracking Signals (2023)

Abstract We propose a learning‐based approach for full‐body pose reconstruction from extremely sparse upper body tracking data, obtained from a virtual reality (VR) device. We leverage a conditional variational autoencoder with gated recurrent units to synthesize plausible and temporally coherent motions from 4‐point tracking (head, hands, and waist positions and orientations). To avoid synthesizing implausible poses, we propose a novel sample selection and interpolation strategy along with an anomaly detection algorithm. Specifically, we monitor the quality of our generated poses using the anomaly detection algorithm and smoothly transition to better samples when the quality falls below a statistically defined threshold. Moreover, we demonstrate that our sample selection and interpolation method can be used for other applications, such as target hitting and collision avoidance, where the generated motions should adhere to the constraints of the virtual environment. Our system is lightweight, operates in real‐time, and is able to produce temporally coherent and realistic motions.
Governing Morals: A Social History of Moral Regulation (2001)

1. The theory and politics of moral regulation 2. Compulsion to virtue: societies for the reformation of manners and the prosecution of vice 3. Moral regulation from above: the vice society 4. From sexual purity to social hygiene, 1870-1918 5. Moral regulation in America 6. Sexual purity, maternal feminism and class in late-Victorian Britain 7. Traditionalizing moral regulation: making sense of contemporary moral politics.
Charge propagation through- and neutron sensitivity of- reticulated vitreous carbon foam (2015)

Several potential neutron conversion materials have been studied over the past several years due to the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He shortage. One candidate neutron conversion material is reticulated vitreous carbon (RVC) foam which can function as a coated substrate and is also suitable for high temperate environments. However, one concern with the material is the charge carrier propagation characteristics through the bulk of RVC foam. Electron propagation through the bulk of RVC foam samples was studied by comparing the resulting count rates and peak channel locations, with and without a sample present, for samples with linear pore densities ranging from 5-100 pores per linear inch (PPI). Count rates and pulse-height spectra from charge carriers generated by collimated 5.48 MeV <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">241</sup> Am alpha particles were studied and are reported here. The observed count rate and pulse height peak locations indicate that some electrons are able to drift through the 5 PPI sample. The peak channel locations with and without the 5 PPI sample were 230 and 360, respectively. However, all other linear pore density samples tested yielded much lower pulse heights, indicating loss of induced charge. Additionally, the intrinsic thermal neutron detection efficiency of a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> C-coated 45 PPI RVC foam sample was 3.23 ± 0.05%, indicating that the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> C-coated sample essentially functioned similar to a thin-film-coated device. Finally, the coating thickness of the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> C coating layer was measured using a SEM to be 1.29 ± 0.47 μm.
ChemInform Abstract: Thioamides, Thioureas and Related Selenium and Tellurium Compounds (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The development of riluzole derivatives with improved potency (2013)

Divergent evolution for more than 310 million years has resulted in an avian immune system that is complex and more compact than that of primates, sharing much of its structure and functions. Not surprisingly, well conserved ancient host defense molecules, such as defensins and cathelicidins, have diversified over time. In this review, we describe how evolution influenced the host defense peptides repertoire, its distribution, and the relationship between structure and biological functions. Marked features of primate and avian HDPs are linked to species-specific characteristics, biological requirements, and environmental challenge.
Insulin-Like Growth Factors (1997)

The insulin-like growth factors (IGFs) participate in the growth and function of almost every organ in the body.1 Because of the wide range of their biologic effects and their therapeutic potential in a variety of clinical disorders, the IGFs have become the focus of research by an increasing number of investigators.24 The object of this seminar is to review the clinical aspects of the IGFs, including their potential therapeutic value, and to discuss briefly their structure, synthesis, regulation, and physiologic role.Basic Biochemistry and Physiologic FunctionsStructure and SynthesisThe three peptide hormones, or growth factors, in the IGF . . .
Retracted: Genes Involved in Apoptosis Regulation: Implications for Cancer Therapy (2005)

The article titled “Genes Involved in Apoptosis Regulation: Implications for Cancer Therapy,” published in Current Genomics (CG), has been retracted. Following a formal complaint and subsequent investigation, it was determined that a significant portion of the content in this review closely resembles an earlier article published online in 2003 (DOI: 10.2174/1570160033378358) authored by the same individuals. This constitutes substantial text recycling or self-plagiarism and violates the journal’s publication ethics. Such duplication constitutes a serious breach of publishing ethics and is considered plagiarism. In accordance with our policies, this article is hereby retracted from the journal record. We apologize to our readers and to the original author for any inconvenience caused. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Role of C-Reactive Protein in Atherogenesis (2005)

No marked effect of rbCRP on the formation of moderately advanced atherosclerotic lesions could be discerned in the apoE knockout mouse. Because of the oddities of the mouse complement system, however, this may not be a good model to investigate the role of CRP in human atherosclerosis.
<title>Content-based multiresolutiuon indexing and retrieval of paleontology images</title> (2001)

In this article a research work in the field of content- based image retrieval in large database applied to the Paleontology image database of the universite de Bourgogne, Dijon, France called 'TRANS TYFIPAL' is proposed. Our indexing method is based on multiresolution decomposition of database images using wavelets. For each kind of paleontology images we try to find a characteristic image representing it. This model image is computed using a classification algorithm on the space of parameters extracted from the wavelet transform of each image. Then a search tree is built to offer users a graphic interface for retrieving images. So that users have to navigate through this tree to find an image similar to that of their request. Our contribution in the field is the building of the model and of the search tree to make user access easier and faster. This paper ends with a conclusion on first coming results and a description of future work to be done to enhance our indexing and retrieval method.
CD13 (aminopeptidase N) can associate with tumor‐associated antigen L6 and enhance the motility of human lung cancer cells (2005)

Cancer metastasis is a multiple-step process that involves the regulated interaction of diverse cellular proteins. We recently reported that the expression of tumor-associated antigen L6 (TAL6) promoted the invasiveness of lung cancer cells and was inversely correlated with disease-free survival of squamous lung carcinoma patients. We now report that CD13 (aminopeptidase N) can associate with TAL6 and can enhance cancer cell migration. CD13 was shown by coimmunoprecipitation to associate in vitro with TAL6 on several cancer cell lines and to associate in vivo by antibody-mediated copatching immunofluorescence. CD13 was selectively expressed on highly invasive CL1-5 lung cancer cells as compared to poorly invasive CL1-0 lung cancer cells. The role of CD13 aminopeptidase activity in regulating cell motility was investigated with chemical inhibitors, specific antibodies and a catalytically inactive CD13 protein. Inhibition of CD13 aminopeptidase activity by nontoxic concentrations of leuhistin modestly decreased the migration of CL1-5 cells. In contrast, binding of CD13 by specific antibodies significantly reduced both the migration and the invasion of CL1-5 cells. Poorly invasive CL1-0 cells that stably expressed CD13 displayed significantly (p < or = 0.0005) enhanced cell migration (300% of control). Expression of an enzymatically inactive CD13 mutant on CL1-0 cells also significantly (p < or = 0.0005) enhanced cell migration (200% of control). Our results show that TAL6 and CD13 can form a complex on lung cancer cells, that these molecules can modulate cell migration and invasion and that the influence of CD13 on cell motility did not strictly depend on its aminopeptidase activity.
2‐Amino‐4‐anilino‐6‐(chloromethyl)‐ s ‐triazine (2003)

Abstract 2‐Amino‐4‐anilino‐6‐(chloromethyl)‐ s ‐triazine product: 2‐amino‐4‐anilino‐6‐(chloromethyl)‐ s ‐triazine product: 2‐Chloromethyl‐4,6‐diamino‐ s ‐triazine
Link Estimation and Rate Control for Optimized Video Streaming on Overlay Networks (2006)

A set of applications such as IP-TV, Internet video broadcasting, corporate telecast or E-learning require simultaneous transmission of video streaming over the Internet. However, conventional solutions for Internet streaming services have exhibited several disadvantages such as server overload and congestion in the immediate network nodes, especially in case of large number of clients. These solutions are also failed to provide QoS-guarantees for streaming services across a heterogeneous internet. In this article, we propose a novel overlay architecture that is designed for multimedia streaming transmission on the Internet. Basic facility for overlay multicast has been introduced, which can relay a single content to multiple users with consideration of bandwidth available on the overlay links. Also, we deploy a link estimation algorithm to analyze the overlay link condition, which is exposed to congestion and interference. Based on the link estimation algorithm, we developed a rate adaptation algorithm to adapt the transmission rate to the downstream available bandwidth. Our real implementation shows that the new proposed algorithms greatly improve the perceived quality of service at the client, while better utilize network resources.
Scanning Hall Probe Microscopy Of Ferromagnetic Structures (2005)

A state-of-the-art scanning Hall probe microscope (magnetic eld sensitivity : spatial resolution: 30 nT/JHz : 0.8 lm}300 nT/JHz : 0.25 lm) has been used to image a range of ferromagnetic media. The technique is non-invasive and yields quantitative proles of the stray elds near the sample surface as illustrated by images of a standard magnetic reference sample, permalloy nanostructures and colossal magnetoresistive perovskites. Rapid scanning (&1 frame/12 sec) has also been used to study the domain reversal in a thin Ni lm. ( 1999 Published by Elsevier Science B.V. All rights reserved.
X-ray standing-wave determination of surface structure: Au on Si(111) (1986)

The structure of Au submonolayers on Si(111) has been investigated as a function of annealing using x-ray standing waves. Au ${L}_{\mathrm{III}}$ photoelectron yields reveal that the Au sites are embedded in the topmost Si(111) planes, the precise position being dependent on the extent of annealing. Standing-wave yields of the Si LVV and KLL Auger electrons were also measured, before and after Au deposition. These results show that the initially contracted Si surface relaxes outwards along with the embedded Au atoms with continued incorporation of Au into the surface.