gebhart/patrepeval huggingface dataset:
1158: Multi-Institutional Review of Pathological Margins after Robot-Assisted Laparoscopic Prostatectomy (RLP) (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 9:00 am - 12:00 pm1 Apr 20061158: Multi-Institutional Review of Pathological Margins after Robot-Assisted Laparoscopic Prostatectomy (RLP) Thomas E. Ahlering, Vipul R. Patel, David I. Lee, and Douglas W. Skarecky Thomas E. AhleringThomas E. Ahlering More articles by this author , Vipul R. PatelVipul R. Patel More articles by this author , David I. LeeDavid I. Lee More articles by this author , and Douglas W. SkareckyDouglas W. Skarecky More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33383-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1158: Multi-Institutional Review of Pathological Margins after Robot-Assisted Laparoscopic Prostatectomy (RLP)." The Journal of Urology, 175(4S), p. 372 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 372 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Thomas E. Ahlering More articles by this author Vipul R. Patel More articles by this author David I. Lee More articles by this author Douglas W. Skarecky More articles by this author Expand All Advertisement PDF downloadLoading ...
CHAPTER 7. Metabolism and Genetics of Algal Hydrogen Production (2018)

Algal hydrogenase research continues to provide important new insights into the origin and function of H2 metabolism in photoautotrophic microorganisms. Additionally, powerful new genetic tools are emerging to manipulate algae, which when combined with the discovery of promising new enzymes are enabling advanced recombinant techniques with the potential to improve H2 production in photoautotrophic organisms. In recent years, more O2-tolerant enzymes have been reported, and “clean” backgrounds that have endogenous hydrogenase activity eliminated in the model organism Chlamydomonas reinhardtii have emerged. Recombinant enzymes are now readily expressed and tested in this system and initial results show promise for improved H2 production. Several algal genomes/transcriptomes have also recently become available, providing important insights into the evolution and function of native hydrogenases in algae. These efforts suggest an evolutionary relationship among algal hydrogenases that implies a single, ancient incorporation of H2 metabolism in eukaryotic algae. In summary, the algal hydrogenase field has advanced dramatically in recent years and additional important insights are likely in the coming years.
Primary and Acquired Resistance of Colorectal Cancer Cells to Anti-EGFR Antibodies Converge on MEK/ERK Pathway Activation and Can Be Overcome by Combined MEK/EGFR Inhibition (2014)

These results suggest that activation of MEK is involved in both primary and acquired resistance to cetuximab and the inhibition of EGFR and MEK could be a strategy for overcoming anti-EGFR resistance in patients with colorectal cancer.
User comments on a clinical event monitor. (1994)

Columbia-Presbyterian Medical Center's health care providers have access to alerts and interpretations generated by an Arden Syntax-based clinical event monitor. They have the opportunity to send comments to the clinical information services staff. Over a period of 26 months, they sent 126 comments. The comments were analyzed using the critical incident technique, resulting in a hierarchy of categories that summarizes user concerns. The majority of comments (65) indicated that the messages were actually (8) or at least potentially useful (57). A minority (28) indicated that they were unhelpful (27) or actually harmful (1). Another group (27) made suggestions or asked questions. The comments have been very helpful for the maintenance of Medical Logic Modules (MLMs) and the clinical event monitor itself.
A quantitative approach for estimating the opportunity cost with cross-selling (2011)

Most inventory models suppose that opportunity cost of lost sales includes lost revenue and penalty cost (goodwill loss), where the lost revenue is equal to the item’s price or marginal profit. However, efficient method for evaluating the penalty cost has not been proposed. In this paper, considering cross-selling effect that the lost sales of one item may influence the sales of other items, we propose a quantitative approach to estimate the opportunity cost based on association rules, in which the penalty cost of lost sales is regarded as the sum of partial dollar usage of all the other related items. Therefore, the opportunity cost of an item is defined as the sum of its own dollar usage and all associated dollar usage. We prove that the unit opportunity cost (UOC) of an item is equal to its own unit dollar usage added the sum of the product that multiplies the unit dollar usage of the associated item by the corresponding confidence. A numerical example and an empirical study with two datasets are used to evaluate the proposed approach. The utility of the opportunity cost is also remarked by analysing the influences of the opportunity cost on inventory policy.
Traumatic Brain Injury Mortality and Correlates in Low- and Middle-Income Countries: A Meta-Epidemiological Study (2023)

TBI-related mortality in LMICs is 3-fold to 4-fold higher than that reported in high-income countries. Within LMICs, parameters associated with poorer outcomes after TBI include factors recognized as social determinants of health. Addressing social determinants of health in LMICs might expedite the quest to close the care delivery gap after TBI.
Toward an automated system for the analysis of cytogenetic abnormalities using fluorescence in situ hybridization technique (2004)

In order to build an automatic system that searches, acquires and analyses chromosomal aberrations, we have coupled a commercial system, Metafer4 (MetaSystems, Germany), with an original software (VRAIC) that is able to separate normal from aberrant metaphase images. Images of metaphases are first stained with a FISH technique and then acquired in three different channels: a BLUE channel, where all chromosomes are stained, a RED channel and a GREEN channel, where only specific pairs of chromosomes are stained. The analysis takes place in three stages. Images are first segmented in the BLUE channel by an edge detection technique. Edge sets not belonging to chromosomal contours are then eliminated by thresholding techniques. Finally, segmentation obtained in the first stage is used to facilitate detection of chromosomal aberrations in the the RED and GREEN channels.
Fracture of crystalline silicon nanopillars during electrochemical lithium insertion (2012)

From surface hardening of steels to doping of semiconductors, atom insertion in solids plays an important role in modifying chemical, physical, and electronic properties of materials for a variety of applications. High densities of atomic insertion in a solid can result in dramatic structural transformations and associated changes in mechanical behavior: This is particularly evident during electrochemical cycling of novel battery electrodes, such as alloying anodes, conversion oxides, and sulfur and oxygen cathodes. Silicon, which undergoes 400% volume expansion when alloying with lithium, is an extreme case and represents an excellent model system for study. Here, we show that fracture locations are highly anisotropic for lithiation of crystalline Si nanopillars and that fracture is strongly correlated with previously discovered anisotropic expansion. Contrary to earlier theoretical models based on diffusion-induced stresses where fracture is predicted to occur in the core of the pillars during lithiation, the observed cracks are present only in the amorphous lithiated shell. We also show that the critical fracture size is between about 240 and 360 nm and that it depends on the electrochemical reaction rate.
DEMOLDING OF HIGH ASPECT RATIO POLYMERIC MICRO-PATTERNING (2005)

UV embossing for polymeric micro-patterning thin film is an emerging replication technique. This paper investigates UV curable multifunctional acrylates pre-polymer resin patterned by a micro-structured mold and subsequently cured by UV irradiation. To further enhance this duplication method for high aspect ratio production, demolding must be reliable and repeatable without damage to the embossing or mold. Previously, it has been reported that UV embossed patterns for aspect ratios as high as 14 have been achieved experimentally. Finite element analyses for patterns with aspect ratios of 5 using parallel demolding between two parallel plates have also been reported. However, the parallel demolding method may not be suitable for large area patterns as forces generated were high. As such, an alternative demolding method, namely peel demolding, for micro-patterns with an aspect ratio of 14 was investigated and key parameters identified. The parameters governing the demolding process were the peel angle, the pre-crack condition, shrinkage, interface fracture toughness, tensile strength and modulus of polymer. A pre-crack between the polymer and mold was introduced before peel demolding. Numerical analyses in terms of Cohesive Zone Modeling (CZM) were used to simulate the demolding process. Shrinkage caused by UV exposure was represented by thermal strain effects and the fully cured polymer was peeled off using displacement control. The ultimate tensile strength (U.T.S) of the cured polymer was used as a failure criterion. The stresses involved were crucial for determining clean demolding. As peeling progressed, stresses experienced in the polymer matrix increased rapidly in the region ahead of the crack with little or no stress at the cracked region. When stresses experienced by the polymer were below the U.T.S, demolding was deemed to be successful.
Cell discrimination by multiangle light scattering. (1976)

Measurement of the light scattered by biological cells as a function of scattering angle provides information that can be correlated with cell type. Two flow systems that provide multiangle scattering data from cells have been constructed and tested. The first utilizes two narrow-aperture detectors positioned at different angles; the second utilizes the motion of the cell to generate complete scatter patterns of individual cells over a 67 degrees range of scattering angle.
Questions to and answers from the International AIDS Society-USA Resistance Testing Guidelines Panel. (2003)

In 1996 the International AIDS Society-USA convened an international panel of experts in HIV drug resistance and clinical management to develop guidelines for the clinical use and limitations of resistance testing. Since then the International AIDS Society-USA Resistance Testing Guidelines Panel has developed and regularly published its recommendations. The latest panel recommendations appear in the July 1 issue of Clinical Infectious Diseases. We periodically pose questions to the panel relating to clinical elements of resistance testing that have been collected from HIV practitioners across the nation. We are happy to feature the latest edition in this issue of Topics in HIV Medicine. It is our hope that addressing these issues will help guide your treatment strategy decisions regarding resistance testing.
Stem Cell Fate Specification: Role of Master Regulatory Switch Transcription Factor PU.1 in Differential Hematopoiesis (2005)

PU.1 is a versatile hematopoietic cell-specific ETS-family transcriptional regulator required for the development of both the inborn and the adaptive immunity, owing to its potential ability to regulate the expression of multiple genes specific for different lineages during normal hematopoiesis. It functions in a cell-autonomous manner to control the proliferation and differentiation, predominantly of lymphomyeloid progenitors, by binding to the promoters of many myeloid genes including the macrophage colony-stimulating factor (M-CSF) receptor, granulocyte-macrophage (GM)-CSF receptor alpha, and CD11b. In B cells, it regulates the immunoglobulin lambda 2-4 and kappa 3' enhancers, and J chain promoters. Besides lineage development, PU.1 also directs homing and long-term engraftment of hematopoietic progenitors to the bone marrow. PU.1 gene disruption causes a cell-intrinsic defect in hematopoietic progenitor cells, recognized by an aberrant myeloid and B lymphoid development. It also immortalizes erythroblasts when overexpressed in many cell lines. Although a number of reviews have been published on its functional significance, in the following review we attempted to consolidate information about the differential participation and role of transcription factor PU.1 at various stages of hematopoietic development beginning from stem cell proliferation, lineage commitment and terminal differentiation into distinct blood cell types, and leukemogenesis.
Advanced array optimizations for high performance functional languages (1995)

We discuss and evaluate three optimizations for reducing memory management overhead and data copying costs in SISAL 1.2 programs that build arrays. The first, called framework preconstruction, eliminates superfluous allocate-deallocate sequences in cyclic computations. The second, called aggregate storage subsumption, reduces the management overhead for compound array components. The third, called predictive storage preallocation, eliminates superfluous data copying in filtered array constructions and simplifies their parallelization. We have added all three optimizations to the Optimizing SISAL Compiler with rewarding improvements in SISAL program performance on vector-parallel machines such as those built by Cray Computer Corporation, Convex, and Cray Research.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development of a foot care model to determine the risk of foot problems among homeless adults in Canada (2021)

Foot care is a common problem for homeless adults in cities, who often receive fragmented foot care services, resulting in increased foot problems, health complications, hospitalisation, limb removal and disabilities. Among the health factors that negatively affect the homeless, foot health is essential, but often neglected. This study employed a descriptive, cross-sectional research design to assess the foot care of homeless people and develop recommendations for clinical practice. Using Inlow's 60-s foot screening method, the foot conditions of a purposive sample of 65 homeless adults were examined in British Columbia, Canada, in 2019-2020. Descriptive and inferential statistics were used to analyse the data. Determinants, such as sex and years of homelessness significantly contributed to homeless individuals' risk of developing foot problems. Differences in perceived and observed foot problems were influenced by equitable access to social health and healthcare services. Foot assessment is not well-covered by homeless health services and should be implemented as part of the standard medical review of homeless patients. Furthermore, foot assessment should be conducted by healthcare professionals, rather than relying on the standard practice of service users' self-report. Finally, foot care should be based on tailoring assessments and interventions for the individualised needs of homeless service users. Future research must seek ways to integrate homeless individuals' voices in the development, implementation and evaluation of foot care services.
Inrush-Current Limiting and Soft-Switching Techniques for Filament Light Source Regulator (2019)

Inrush-current limiting voltage regulators are considered important components in many voltage and current drivers applications, to reduce the startup surge of current from the voltage supply to the supplied loads. Moreover, driving stable current to multiple filament light sources is necessary to improve their life-time and reduce light fluctuations. In this paper, a fully-integrated soft-start linear voltage regulator is proposed, for driving high current to filament light sources. In addition to the soft startup feature, this proposed technique is used to allow introducing new loads during operation without disturbing the regulated output. The design has been implemented in 130nm technology. The maximum driving current is 1.5A from 5V supply. Minimum drop-out voltage of 250mV is used to supply different filament light sources.
Trans isomers of EPA and DHA in refining and concentration of fish oils. (2015)

The omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are strongly recommended to be part of a normal diet due to the many positive health effects in humans. Health authorities in many countries recommend an average daily intake of 0.25 – 0.5 grams of EPA and DHA by eating fish at least twice a week or alternatively, consume fish oil supplements. The unsaturated fatty acids in native marine and vegetable lipids are all present as cis-isomers while trans-isomers are found in industrially hydrogenated oils and in minor amounts in fat from ruminants. The intake of large amounts of trans-fatty acids is considered to have serious negative health effects and the advices are to reduce the consumption as much as possible. \n\tSeveral processing steps are necessary to produce high quality fish oil supplements, including concentrated forms of EPA and DHA. These steps include high temperature processes that might induce transformation of cis-double bonds to trans-double bonds in the unsaturated fatty acids. The objectives of this thesis was determine if the processing conditions used at Nordic Pharma Inc. resulted in the formation of trans fatty acids in both natural “1812” fish oils (18 % EPA, 12 % DHA) and EPA/DHA concentrates and to investigate how time and temperature used in the processing steps affected the formation of trans fatty acids in fish oil concentrates. Initially, a method for the analysis of trans fatty acids in fish oils was established. \nMethylated standards of trans EPA and DHA were produced using p-toluenesulfinic acid as catalyst and separating the different isomers on high performance thin layer chromatography (HPTLC) plates impregnated with silver nitrate. A 100 meter SLB-IL111, the most polar gas chromatography (GC) column commercially available, was used to analyze the samples. The preparation and the separation of the trans standards on HPTLC plates was successful and gave sufficient amounts to optimize a temperature program for GC separation. The results from samples of processed fish oil showed that only minor amounts of trans fatty acids were formed during the processing conditions applied at Nordic Pharma Inc. The content of trans fatty acids was far below the amount allowed for such products. The SLB-IL111 column worked well as a tool for analysis of trans fatty acids in fish oil, but some further investigations are needed for this analysis system to be optimized. The temperature experiment showed that 200 °C for more than an hour was needed for the formation of larger amounts of trans LC-PUFA to occur. \n\nKeywords: Fish oil, industrial processing, trans fatty acids, EPA, DHA, SLB-IL111, silver ion TLC
Hypertonic Saline Therapy in Cystic Fibrosis (2006)

Recent data indicate the clinical benefit of nebulized hypertonic saline in cystic fibrosis lung disease, with a proposed mechanism involving sustained increase in airway surface liquid volume. To account for the paradoxical observation that amiloride suppresses the beneficial effect of hypertonic saline, it has been previously concluded (Donaldson, S. H., Bennett, W. D., Zeman, K. L., Knowles, M. R., Tarran, R., and Boucher, R. C. (2006) N. Engl. J. Med. 354, 241-250) that amiloride-inhibitable aquaporin (AQP) water channels in airway epithelia modulate airway surface liquid volume. Here, we have characterized water permeability and amiloride effects in well differentiated, primary cultures of human airway epithelial cells, stably transfected Fisher rat thyroid epithelial cells expressing individual airway/lung AQPs, and perfused mouse lung. We found high transepithelial water permeability (P(f), 54 +/- 5 microm/s) in airway epithelial cells that was weakly temperature-dependent and inhibited by >90% by reduced pH in the basal membrane-facing solution. Reverse transcription-PCR and immunofluorescence suggested the involvement of AQPs 3, 4, and 5 in high airway water permeability. Experiments using several sensitive measurement methods indicated that amiloride does not inhibit water permeability in non-cystic fibrosis (non-CF) or CF airway epithelia, AQP-transfected Fisher rat thyroid cells, or intact lung. Our data provide evidence against the mechanism proposed by Donaldson et al. to account for the effects of amiloride and hypertonic saline in CF lung disease, indicating the need to identify alternate mechanisms.
A Compact circularly polarized multilayer printed antenna for use on micro-satellites (2012)

This paper presents the results of an investigation into a compact circularly polarized (CP) antenna for operation at 400MHz. The antenna consists of an array of four folded shorted patch (S-P) elements constructed using multilayer printed circuit board (PCB) technology. The overall dimensions of the antenna are 0.2λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> X 0.2λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> X 0.05λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> . The design may be applicable for CP antenna systems on micro-satellites where size is critical.
OX40 boosts and sustains humoral and cellular immune responses to SARS-CoV2 spike protein and RNA vaccinations (2022)

Abstract To prevent SARS-CoV-2 infections and generate long-lasting immunity, vaccines need to generate both, a strong humoral immune response as well as viral-specific CD4 and CD8 T cells. Previous results from our lab have shown that immunization in the presence of an agonist antibody targeting OX40 led to higher antibody titers and increased numbers of antigen-specific CD4 and CD8 T cells. Using the same strategy, we explored the effect of OX40 co-stimulation in the prime and boost together with the SARS-CoV-2 spike protein + adjuvant in C57Bl/6 mice. Our results show that OX40 engagement led to a significant increase in long-lived antibody responses when compared to mice that did not receive additional co-stimulation. In addition, spike protein and peptide-specific proliferation were greatly increased for both CD4 and CD8 T cells, with augmented secretion of IFN-γ, TNF-α and IL-2. Booster immunizations (7 months post prime) did not lead to anergy, but instead further increased the antibody and T cell responses. In initial experiments, the self-amplifying RNA (saRNA) vaccination generated lower antibody titers, independent of OX40 co-stimulation. However, the saRNA vaccine did induce a robust expansion of antigen-specific CD8 T cells, that expressed high levels of GrzmB, which was further increased by OX40 administration. The strong immune responses and the differential effects of the protein and saRNA vaccines suggest that heterologous prime-boost approaches, as currently approved in adults, might be beneficial in boosting different arms of the anti-viral immune response against SARS-CoV2, with OX40 agonists enhancing both approaches. Further studies in animals will aid defining the effects and benefits of this approach.