gebhart/patrepeval huggingface dataset:
Regional fMRI Hypoactivation and Altered Functional Connectivity During Emotion Processing in Nonmedicated Depressed Patients With Bipolar II Disorder (2012)

These findings suggest that bipolar II depression is characterized by reduced regional orbitofrontal and limbic activation and altered connectivity in a fronto-temporal circuit implicated in working memory and emotional learning. While the amygdala hypoactivation observed in bipolar II depression is opposite to the direction seen in bipolar I mania and may therefore be state dependent, the observed orbitofrontal cortex hypoactivation is consistent with findings in bipolar I depression, mania, and euthymia, suggesting a physiologic trait marker of the disorder.
Effect of Ruboxistaurin on Blood–Retinal Barrier Permeability in Relation to Severity of Leakage in Diabetic Macular Edema (2005)

RBX treatment was associated with a reduction of retinal vascular leakage in eyes that had diabetic macular edema and markedly elevated leakage at baseline. These data suggest that clinical benefit from RBX treatment may be most prominent in patients with severe macular edema at baseline, and trials investigating this therapy may benefit from stratification according to baseline leakage.
Vibration of Air Suspension Bogies and Their Design (1970)

In this paper, at first the authors analyze the dynamic characteristics of the self-damped air spring on the basis of the linear theory from the standpoint of the design of air suspension bogies. The equivalent mechanical model of the self-damped air spring is obtained, which is a kind of socalled elastically supported damper systems, and the relationship among the elements of the model and the design parameters of the air spring are given. Then, using the mechanical model, both natural vibration and transient response of the air suspension bogie are analyzed numerically. As the result, it is shown that the natural frequency and the damping ratio of the self-damped air suspension bogie scarcely vary with the car body weight, and the self-damped air suspension can reduce the magnitude of the transient response compared with a conventional mechanical suspension with oil-dampers.
A Phase II Study of Single Agent Gemcitabine in Relapsed or Refractory Follicular or Small Lymphocytic Non-Hodgkin Lymphomas (2005)

Gemcitabine is a pyrimidine analog that is active in patients with aggressive lymphomas and Hodgkin disease. This study assessed tumor response in patients with previously treated follicular or small lymphocytic non-Hodgkin lymphoma. This was a 2-stage phase II trial with the first stage requiring 2 of 13 responses to proceed to the second stage. Gemcitabine was given as a single agent to patients with previously treated follicular or small lymphocytic lymphomas. Gemcitabine was administered at 1250 mg/m2 over 30 minutes on days 1 and 8 of a 21-day cycle for a maximum of 6 cycles. Thirteen patients were treated with 1 to 6 cycles of chemotherapy. Two patients experienced grade 4 toxicity with neutropenia. No grade 4 nonhematologic toxicity was seen. There was 1 partial response and 8 patients (61%) had either minimal response or stable disease. Single-agent gemcitabine administered at this dose and schedule produced 1 partial remission and half the patients had stable disease. However, the study had to be stopped early because of lack of meaningful response.
ADVANCED TECHNOLOGY DEVELOPMENTS IN REMEDIAL STAVE COOLING (2016)

The premature failure of copper staves in the lower stack and bosh is frequently the cause for an interim blast furnace repair at great cost to the blast furnace owner. Protective accretions may form on the stave hot face, but when these accretions are lost the staves can begin to deteriorate both due to abrasive wear from exposure to the descending burden materials and due to thermal cracking from exposure to hightemperature process excursions. These mechanisms can lead to failure of cooling passages, which forces blast furnace operators to shut off these channels, accelerating the rate of copper stave wear. Finger cooler technology was developed to extend blast furnace life by restoring cooling to damaged staves. Evidence for their effectiveness is presented herein in the form of experimental test work and conjugate heat transfer (CHT) analysis carried out using computational fluid dynamics (CFD) simulations. These tests demonstrate that under typical blast furnace excursion conditions, a stave fitted with finger coolers will undergo half the temperature rise of a stave fitted with conventional cigar coolers.
ChemInform Abstract: Copper‐Catalyzed Synthesis of 2,4‐Disubstituted Allenoates from α‐Diazoesters. (2011)

Abstract The reaction requires the use of K 2 CO 3 and 2 equiv.
The use of monoclonal antibodies to quantify airway mucin content in human bronchio-alveolar lavage fluid (1998)

Mucus hypersecretion is a characteristic of some airway diseases. A method of quantifying the mucin content of the fluid in human airways would facilitate the identification and testing of drugs capable of attenuating mucus hypersecretion.



Two monoclonal antibodies, 2D11 and 4H6, which recognize some mammalian mucins, were used to develop an ELISA method for quantifying the amount of mucin in bronchioalveolar lavage fluid (BALF) from human airways. To this end, information on the epitopes of these two antibodies is provided. Endo-α-N-acetylgalactosaminidase treatment reduced their reactivity with substrates. Susceptibility to this enzyme suggests the partial involvement of the structures around the GalNAc α1-serine or threonine bond in the epitope. A sandwich-type ELISA method using 2D11 and 4H6 was developed. This was used to quantify the mucin level in human BALF from patients with various airway diseases.



This mucin quantification system should prove useful for detecting airway injury, as well as for evaluating potential drugs for attenuating mucus hypersecretion.
Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer (2016)

These results illustrate for the first time CRC mutational profile in Iranian patients. MSH3, MSH6, APC and PIK3CA genes seem to play a bigger role in the path to cancer in this population. These findings will potentially lead to informed genetic diagnosis protocol and targeted therapeutic strategies.
Data-Driven Diagnosis for Artificial Lift Pump's Failures (2019)

Abstract Beam pump and ESP are common artificial lift techniques in pumping systems. They are widely used as primary oil recovery methods, but system failures lead to production deferments and increases in operating expenses. Employing decades of our field data, promising data science techniques are discussed here to analyze the factors governing failures in both beam pump and ESP approaches. These data are then applied with machine learning models to predict service life, failure mechanism performance, and production deferments. The data analytics process begins with data preparation. Field data were extracted, transformed and loaded into a data warehouse for further processing. These data were categorized by failure information, pump configuration, wellbore geometry, and production information. The significance of each parameter causing pump failures was derived using a process called "Attribute Forward Selection (AFS)." Then several machine learning algorithms were implemented and compared with to determine the most appropriate model to predict pump service life. More suitable pump configurations to improve pump service life were conceptually recommended based on the analysis. Differences in parameter significance was identified by attribute forward selection, and is displayed in a heat map. It was seen that the use of beam pumps in highly tortuous wells received the number one ranking as the main cause of failures whereas sand production was revealed as the most significant parameter relating to ESP failures. Correlations for these parameters were mapped by machine learning algorithms, resulting in multivariate failure prediction models (i.e. involving more than one parameter at a time) to predict the service life of beam pump and ESP systems. For both artificial lift systems, the models with the best correlation found thus far are based on a neural network, which resulted in the highest R-squared values when compared to other techniques. This neural network model was validated with the actual information, and the outcomes using this model are presented via a scatter plot in this paper. The plot shows that the prediction for ESP forms a trend around the theoretical best match line. In contrast, the prediction for Beam pump still needs improvement, with the data being scattered around the straight line with a unity slope. Data science is an emerging technology that recently has provided breakthrough results for big data analysis. This paper will demonstrate the application of such discipline to the area of artificial lift. Machine learning is a promising tool which could help improve human understanding of complex problems, and, in this case, could furnish a durable competitive advantage to the oil and gas industry.
Overexpression of p53 Improves Blood Glucose Control in an Insulin Resistant Diabetic Mouse Model (2016)

Activation of p53-mediated glucose metabolism led to insulin-like antidiabetic effect in the mouse model especially by changing hepatic insulin sensitivity in the diabetic mouse model.
Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC‑1 cells (2019)

Hyperthermia (HT) has shown potential in cancer therapy. In particular, it appears to sensitize cancer cells to chemotherapy. However, a major concern associated with HT is that the thermal dosage applied to the tumor cells may also harm the normal tissue cells. Besides, the drugs used in HT are conventional chemotherapy drugs, which may cause serious side effects. The present study demonstrated a novel methodology in HT therapy called thermal cycle (TC)‑HT. With this strategy, a therapeutic window with a maximum synergistic effect was created by combining TC‑HT with natural compounds, with minimal unwanted cell damage. The natural compound propolis was selected, and the synergistic anticancer effect of TC‑HT and propolis was investigated in pancreatic cancer cells. The present results demonstrated for the first time that TC‑HT could enhance the anticancer effect of propolis on PANC‑1 cancer cells through the mitochondria‑dependent apoptosis pathway and cell cycle arrest. Combined treatment greatly suppressed mitochondrial membrane potential, which is an important indicator of damaged and dysfunctional mitochondria. Furthermore, the cell cycle‑regulating protein cell division cycle protein 2 was downregulated upon combined treatment, which prevented cellular progression into mitosis. The present study offers the first report, to the best of our knowledge, on the combination of TC‑HT with a natural compound for pancreatic cancer treatment. It is anticipated that this methodology may be a starting point for more sophisticated cancer treatments and may thereby improve the quality of life of many patients with cancer.
Laser manipulation and ablation of a single microcapsule in water (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser manipulation and ablation of a single microcapsule in waterHiroaki Misawa, Noboru Kitamura, and Hiroshi MasuharaCite this: J. Am. Chem. Soc. 1991, 113, 21, 7859–7863Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ja00021a005https://doi.org/10.1021/ja00021a005research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Increased Farnesyltransferase Activity in Human Colorectal Cancer: Relationship with Clinicopathological Features and K-ras Mutation (2003)

Our findings suggest that Farnesyltransferase activity may be a potential marker of tumourigenicity. The differences in Farnesyltransferase activity in relation to histological grading, tumour location and K-ras mutation described here may constitute a starting point for investigating the causes of this variation within the large bowel.
Elementary, my dear Zernike: model order reduction for accelerating optical dimensional microscopy (2022)

Dimensional microscopy is an essential tool for non-destructive and fast inspection of manufacturing processes. Standard approaches process only the measured images. By modelling the imaged structure and solving an inverse problem, the uncertainty on dimensional estimates can be reduced by orders of magnitude. At the same time, the inverse problem needs to be solved in a timely manner. Here we present a method of accelerating the inverse problem by reducing images to their elementary features, thereby extracting the relevant information and distinguishing it from noise. The resulting reduction in complexity allows the inverse problem to be solved more efficiently by utilize cutting edge machine learning based optimization techniques. By employing the techniques presented here, we are able to perform for highly accurate and fast dimensional microscopy.
ALTERATIONS IN T REGULATORY CELL LEVELS IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS ON CALCINEURIN INHIBITORS OR OFF IMMUNOSUPPRESSION (2010)

THURSDAY MORNING - ORAL ABSTRACTS: Striving to Harness the Immune System in Pediatric Solid Organ Transplantation: PDF Only
Accuracy and Cost Comparison of Ultrasound Versus Alternative Imaging Modalities, Including CT, MR, PET, and Angiography (2009)

Ultrasound (US) has become widely used in clinical medicine for the diagnosis of a variety of disease processes. The unique ability of US to provide accurate information through an efficacious, painless, portable, and nonionizing method has expanded its role and application in diverse medical settings. Given the current economic environment and the related interest in creating the greatest value for health care expenditures, US has been evaluated to compare its clinical accuracy/efficacy and cost-effectiveness versus other imaging modalities. The following literature review reports the results of research studies aimed at comparing the accuracy/efficacy and cost of US versus alternative imaging modalities, including magnetic resonance imaging, computed tomography, contrast angiography, and single-photon emission computed tomography.
Post-route gate sizing for crosstalk noise reduction (2004)

Gate sizing is a practical and a feasible crosstalk noise correction technique in the post route design stage, especially for block level sea-of-gates designs. The difficulty in gate sizing for noise reduction is that by increasing a driver size, noise at the driver output is reduced, but noise injected by that driver on other nets is increased. This can create cyclical dependencies between nets in the circuit with noise violations. In this paper, we propose a fast and effective heuristic post-route gate sizing algorithm that uses a graph representation of the noise dependencies between nodes. Our method utilizes gate sizing in both directions and works in linear time as a function of the number of gates. The effectiveness of the algorithm is shown on several high performance designs.
Learn Excel 2011 for Mac (2011)

Microsoft Excel 2011 for Mac OS X is a powerful application, but many of its most impressive features can be difficult to find.Â Learn Excel 2011 for Mac by Guy Hart-DavisÂ isÂ a practical, hands-on approach to learning all of the details of Excel 2011 in order to get work done efficiently on Mac OS X. From using formulas and functions to creating databases, from analyzing data to automating tasks, you'll learn everything you need to know to put this powerful application to useÂ for a variety of tasks.
Partial Grid Forming Concept for 100% Inverter-Based Transmission Systems (2018)

With the current trends in renewable energy integration, the concept of a 100% inverter-based power system is becoming more of a reality. However, the existing Voltage Source Converter (VSC) control schemes for such systems focus mostly on the operation of low-voltage microgrids, which have different requirements from the transmission system perspective. This paper proposes a new classification of VSC control strategies depending on their mode of operation. Then, the concept of partial grid forming VSC is introduced and it is shown that a system with zero rotational inertia can operate without a dedicated grid-forming VSC unit, but rather with partial forming of key system characteristics distributed across different VSC units. The performance of this approach is tested on detailed VSC models developed in both MATLAB Simulink and virtual Hardware-In-the-Loop (vHIL) platforms. Furthermore, an investigation towards necessary converter and network criteria for providing a stable system under the proposed control concepts is presented.
The Development of Comprehensive Search Skills (1984)

WELLMAN, HENRY M.; SOMERVILLE, SUSAN C.; REVELLE, GLENDA L.; HAAKE, ROBERT J.; and SOPHIAN , CATHERINE. The Development of Comprehensive Search Skills. CHILD DEVELOPMENT, 1984, 55, 472-481. 2 studies of young children's comprehensive search skills are reported. The first examined 2Y2-, 3Y2-, and 4Y2-year-olds' ability to conduct nonredundant comprehensive searches of small lidded trash cans. The 2Y2-year-olds achieved comprehensive search only in a lids-open condition, where lids of the cans automatically stayed open (once searched), creating an external record of which locations had been searched. The 3/2-year-olds and 4Y2-year-olds were more able to search comprehensively and nonredundantly in a variety of conditions. The second study examined 3-, 4-, and 5-year-olds' ability to find 5 Easter eggs hidden on a large playground. Eggs were hidden in 2 clusters as the child watched-3 eggs on 1 side of the playground, 2 on the other. Children did not minimize distance in their search paths for finding the eggs. However, they did minimize traverses of the playground, that is, they tended to find all eggs in 1 cluster before searching in the other. Results were discussed in relation to a 3-stage description of the development of comprehensive search strategies where comprehensive search develops out of (a) early forms of search persistence, followed by (b) comprehensive search based on sighting procedures, and finally (c) planned efficient searches.
The traceless Staudinger ligation for indirect18F-radiolabelling (2010)

The Staudinger ligation of phosphine-substituted thioesters with (18)F-fluoroethylazide has been successfully applied to access (18)F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.
Anomaly in the excitation dependence of the optical gain of semiconductor quantum dots (2006)

Optical gain behavior of semiconductor quantum dots is studied within a quantum-kinetic theory, with carrier-carrier and carrier-phonon scattering treated using renormalized quasiparticle states. For inhomogeneously broadened samples, we found the excitation dependence of gain to be basically similar to quantum-well and bulk systems. However, for a high quality sample, our theory predicts the possibility of a decreasing peak gain with increasing carrier density. This anomaly can be attributed to the delicate balance between state filling and dephasing.
Noninvasive Estimates of Local Field Potentials for Brain-Computer Interfaces (2007)

Recent experiments have shown the possibility to use the brain electrical activity to directly control the movement of robots or prosthetic devices in real time. Such neuroprostheses can be invasive or non-invasive, depending on how the brain signals are recorded. In principle, invasive approaches will provide a more natural and flexible control of neuroprostheses, but their use in humans is debatable given the inherent medical risks. Non-invasive approaches mainly use scalp electroencephalogram (EEG) signals and their main disadvantage is that these signals represent the noisy spatiotemporal overlapping of activity arising from very diverse brain regions; i.e., a single scalp electrode picks up and mixes the temporal activity of myriads of neurons at very different brain areas. In order to combine the benefits of both approaches, we propose to rely on the non-invasive estimation of local field potentials (eLFP) in the whole human brain from the scalp measured EEG data using a recently developed inverse solution (ELECTRA) to the EEG inverse problem. The goal of a linear inverse procedure is to deconvolve or unmix the scalp signals attributing to each brain area its own temporal activity. To illustrate the advantage of this approach we compare, using identical set of spectral features, classification of rapid voluntary finger self-tapping with left and right hands based on scalp EEG and eLFP on three subjects using different number of electrodes. It is shown that the eLFP-based Gaussian classifier outperforms the EEG-based Gaussian classifier for the three subjects.
Double-Layer Cross-Coupled Silicon Nitride Multi-Ring Resonator Systems (2020)

We demonstrate a double-layer Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> multi-ring resonator system, where an S-bend waveguide is cross-coupled with a ring cavity loaded with two sub-ring resonators. The device performance is analyzed by using the transfer matrix method. The alignment-error-induced device performance variations are also discussed. The measured spectra coincide well with the simulated results. The device has high tuning flexibility and more design freedom with two sub-rings placed above the ring cavity. The spectrum profile can also be tuned by changing the cross-coupling coefficient. A heater placed above the resonator can shift the resonant wavelength effectively.