gebhart/patrepeval huggingface dataset:
Potassium ions and endothelium‐derived hyperpolarizing factor in guinea‐pig carotid and porcine coronary arteries (1999)

Experiments were designed to determine in two arteries (the guinea-pig carotid and the porcine coronary arteries) whether or not the endothelium-derived hyperpolarizing factor (EDHF) can be identified as potassium ions, and to determine whether or not the inwardly rectifying potassium current and the Na+/K+ pump are involved in the hyperpolarization mediated by EDHF. The membrane potential of vascular smooth muscle cells was recorded with intracellular microelectrodes in the presence of N(omega)-L-nitro-arginine (L-NA) and indomethacin. In vascular smooth muscle cells of guinea-pig carotid and porcine coronary arteries, acetylcholine and bradykinin induced endothelium-dependent hyperpolarizations (-18+/-1 mV, n = 39 and -19+/-1 mV, n = 7, respectively). The hyperpolarizations were not affected significantly by ouabain (1 microM), barium chloride (up to 100 microM) or the combination of ouabain plus barium. In both arteries, increasing extracellular potassium concentration by 5 or 10 mM induced either depolarization or in a very few cases small hyperpolarizations which never exceeded 2 mV. In isolated smooth muscle cells of the guinea-pig carotid artery, patch-clamp experiments shows that only 20% of the vascular smooth muscle cells expressed inwardly rectifying potassium channels. The current density recorded was low (0.5+/-0.1 pA pF(-1), n = 8). These results indicate that, in two different vascular preparations, barium sensitive-inwardly rectifying potassium conductance and the ouabain sensitive-Na+/K+ pump are not involved in the EDHF-mediated hyperpolarization. Furthermore, potassium did not mimic the effect of EDHF pointing out that potassium and EDHF are not the same entity in those arteries.
Response of the Abundance of Key Soil Microbial Nitrogen-Cycling Genes to Multi-Factorial Global Changes (2013)

Multiple co-occurring environmental changes are affecting soil nitrogen cycling processes, which are mainly mediated by microbes. While it is likely that various nitrogen-cycling functional groups will respond differently to such environmental changes, very little is known about their relative responsiveness. Here we conducted four long-term experiments in a steppe ecosystem by removing plant functional groups, mowing, adding nitrogen, adding phosphorus, watering, warming, and manipulating some of their combinations. We quantified the abundance of seven nitrogen-cycling genes, including those for fixation (nifH), mineralization (chiA), nitrification (amoA of ammonia-oxidizing bacteria (AOB) or archaea (AOA)), and denitrification (nirS, nirK and nosZ). First, for each gene, we compared its sensitivities to different environmental changes and found that the abundances of various genes were sensitive to distinct and different factors. Overall, the abundances of nearly all genes were sensitive to nitrogen enrichment. In addition, the abundances of the chiA and nosZ genes were sensitive to plant functional group removal, the AOB-amoA gene abundance to phosphorus enrichment when nitrogen was added simultaneously, and the nirS and nirK gene abundances responded to watering. Second, for each single- or multi-factorial environmental change, we compared the sensitivities of the abundances of different genes and found that different environmental changes primarily affected different gene abundances. Overall, AOB-amoA gene abundance was most responsive, followed by the two denitrifying genes nosZ and nirS, while the other genes were less sensitive. These results provide, for the first time, systematic insights into how the abundance of each type of nitrogen-cycling gene and the equilibrium state of all these nitrogen-cycling gene abundances would shift under each single- or multi-factorial global change.
Secretory patterns of glucoregulatory hormones in prehepatic circulation of dogs (1985)

The temporal organization of patterns of secretion of insulin, glucagon, and somatostatin was studied in basal conditions in normal or pancreatectomized dogs fitted with an indwelling hepatic portal catheter. Portal and peripheral blood samples were collected at a 7.5- or 15-min frequency, which covered the medium range of the ultradian period. The raw data were studied using spectral analyses employing fast Fourier transformation (FFT) techniques. The results indicate that in normal dogs: 1) endogenous physiological periodicities, statistically significant at a level of alpha = 0.05 (i.e., 95% confidence interval), were found to exist for the three pancreatic hormones in portal blood between 0.54 and 1.78 h/cycle and in peripheral blood between 0.59 and 1.84 h/cycle; 2) the portal levels of the hormones are significantly higher than peripheral ones; and, 3) whereas pancreatic hormones oscillated, glucose was found to maintain a steady level. In pancreatectomized dogs, no regular rhythm was detected. Thus, whereas endogenous periodicities exist for the secretion of pancreatic hormones in the normal dog, in the pancreatectomized dog the extrapancreatic glucagon and somatostatin are secreted in nonperiodic, randomly occurring pulses.
Development of a gas chromatographic-ultraviolet absorption spectrometric method for monitoring petroleum pitch volatiles in the environment (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a gas chromatographic-ultraviolet absorption spectrometric method for monitoring petroleum pitch volatiles in the environmentR. A. Greinke and I. C. LewisCite this: Anal. Chem. 1975, 47, 13, 2151–2155Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ac60363a046https://doi.org/10.1021/ac60363a046research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
VIII.—NEW BOOKS (1958)

VIII.—NEW BOOKS The Philosophy of Symbolic Forms. Vol. 2: Mythical Thinking. By ERNEST CASSIRER, translated by RALPH MANHEIM. Yale University Press (London: Geoffrey Cumberlege). Pp. xviii+269. 40s. DOROTHY EMMET DOROTHY EMMET Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXVII, Issue 265, January 1958, Pages 111–112, https://doi.org/10.1093/mind/LXVII.265.111 Published: 01 January 1958
Abstract 3763: IDO vaccine enhances antigen-specific anti-tumor effects by reducing IDO-expressing antigen presenting cells and MDSCs (2018)

Abstract Tumors evade immune surveillance using several mechanisms such as induction of regulatory T-cells (Tregs) and upregulation of indolemine-2,3-dioxygenase (IDO) enzyme. IDO is an intracellular enzyme that mediates its immunosuppressive effects by depleting tryptophan leading to accumulation of kynurenine and in turn reducing the proliferation of effector cells while activating Tregs. IDO is expressed by several suppressive immune cells including Tregs, suppressive antigen presenting cells (APCs), as well as by tumor cells. These immunosuppressive effects of IDO make it an attractive target for cancer immunotherapy, including a target for vaccine therapy. To test the anti-tumor immune effect of IDO vaccine, we evaluated the anti-tumor effect of an IDO-derived MHC I restricted peptide (IDO-pep) vaccine in the low IDO-expressing (TC-1) and high IDO-expressing B16 (melanoma) mouse tumor models. For this, mice were treated with three doses of IDO-peptides in combination with the respective tumor-specific vaccines (E7 for TC-1 and gp100 for B16) at an interval of seven days, followed by assessment of tumor growth and mice survival. We observed a significant delay in the tumor growth and prolonged survival in both tumor models when IDO vaccine was combined with tumor-specific antigen vaccine. We found that tumor-infiltration of antigen-specific CD8+ T-cells was significantly enhanced following the addition of IDO vaccine. Furthermore, while CD4+ T-cells increased in the tumor microenvironment (TME), there was a significant reduction in the numbers of Treg cells. We also found a significant reduction in the numbers of IDO-expressing myeloid-derived suppressor cells (MDSCs), dendritic cells as well as macrophages out of the total CD45+CD11b+ myeloid cells in the TME after the administration of IDO-pep in combination with tumor antigen-specific vaccine. In conclusion, our findings suggest that IDO-pep vaccine enhances the specific anti-tumor immune response by increasing the tumor antigen-specific effector T-cell infiltration in the TME through inhibition of immune suppressive cells. These results also suggest that MHC I restricted IDO peptide treatment is a promising strategy to improve cancer immunotherapy. Citation Format: Rahul Nandre, Vivek Verma, Pankaj Gaur, Pooja Vir, Hua Wang, Baolin Kang, Ayako Wakatsuki Pedersen, Mai-Britt Zocca, Mads Hald Andersen, Seema Gupta, Samir Khleif. IDO vaccine enhances antigen-specific anti-tumor effects by reducing IDO-expressing antigen presenting cells and MDSCs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3763.
Assembled structures of nanocrystals in polymer/calcium carbonate thin‐film composites formed by the cooperation of chitosan and poly(aspartate) (2006)

Abstract Assembled structures of calcium carbonate (CaCO 3 ) nanocrystals have been examined for polymer/CaCO 3 thin‐film composites synthesized through a self‐organization process inspired by biomineralization. For the crystallization of CaCO 3 , a thin‐film matrix of chitosan has been used as a polymeric substrate. When the matrix is immersed into a supersaturated aqueous solution of CaCO 3 containing 1.4 × 10 −3 wt % poly(aspartate) (PAsp), thin‐film crystals of CaCO 3 are formed spontaneously. Three kinds of disklike films have been observed under a polarizing optical microscope. Electron diffraction analyses of each film have revealed that one is aragonite, displaying radial orientation of the c axes, and the others are vaterite, exhibiting different orientations. Detailed observation by scanning electron microscopy has clarified that these films are assemblies of crystalline particles 10–20 nm in size. The thin‐film composites have been obtained over a PAsp concentration range of 4.4 × 10 −4 to 1.0 × 10 −2 wt %. Vaterite formation becomes dominant when the concentration of PAsp is increased. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 5153–5160, 2006
A Novel Method Based DCT to Reduce PAPR of OFDM Systems (2008)

Orthogonal frequency division multiplexing (OFDM) systems based on discrete cosine transform (DCT) is proposed for the first time in this paper in order to solve the distortion due to great Peak-to-Average Power Ratio (PAPR) of OFDM systems signals. The character of the DCT energy focused is made use of in the frequency domain, and it helps to reduce the PAPR engendered by IFFT at the transmitter statistically, avoiding the nonlinear distortion in OFDM systems due to great change of PAPR. In this paper, the characters of DCT algorithm are analyzed first, and then the algorithm is applied to signal processing in OFDM systems. It is mathematically verified that this method is potent to reduce the PAPR. Lastly, the simulation results show that the proposed scheme in reducing the threshold of PAPR statistically is feasible.
A dynamic analysis of the Dickson charge pump circuit (1997)

Dynamics of the Dickson charge pump circuit are analyzed. The analytical results enable the estimation of the rise time of the output voltage and that of the power consumption during boosting. By using this analysis, the optimum number of stages to minimize the rise time has been estimated as 1.4 N/sub min/, where N/sub min/ is the minimum value of the number of stages necessary for a given parameter set of supply voltage, threshold voltage of transfer diodes, and boosted voltage. Moreover, the self-load capacitance of the charge pump, which should be charged up at the same time as the output load capacitance of the charge pump, has been estimated as about one-third of the total charge pump capacitance. As a result, the equivalent circuit of the charge pump has been modified. The analytical results are in good agreement with simulation by the iteration method, typically within 10% for the rise time and within 2% for the power consumption. In the case of a charge pump with MOS transfer transistors, the analytical results of the rise time agree with the SPICE simulation within 10%.
Polymers and single molecule fluorescence spectroscopy, what can we learn? (2008)

This tutorial review summarizes the most important results and developments in the field of polymer science by means of single molecule fluorescence spectroscopy (SMFS) at ambient temperatures. A broad range of topics will be addressed and it will be discussed which single molecule methods are suitable to get the maximum amount of information about polymer structure, polymer dynamics and the photophysics of incorporated or embedded dye molecules. In particular, we will report on the use of polymer films for immobilization of molecules, the visualization of dynamics near the glass transition temperature Tg, the reptation of polymer chains, the conformation adopted by polymer chains and the in situ observation of the polymerization reaction itself.
Abstract 2698: Phosphoproteomics-guided anticancer drug combination design with a novel small-molecule PP2A activator (2018)

Abstract Significance: Phosphatases are cellular antagonists of kinase signaling and have a diverse range of substrates, many of which are ideal targets for small molecule-based anticancer treatment. Our lab and collaborators have generated a novel series of compounds that bind to and activate the serine/threonine protein phosphatase 2A (PP2A), and these small-molecule activators of PP2A (SMAPs) induce apoptosis and inhibit tumor growth in numerous cancer models. Based on these findings, this project aimed to identify drug combinations with our SMAP that could drive optimal anticancer activity. Methods: We first turned to global shotgun phosphoproteomics to compare the signaling response signatures of our SMAP against a combination of a MEK inhibitor (MEKi) and an AKT inhibitor (AKTi). We then applied Kinase-Substrate Enrichment Analysis (KSEA) to extract key diverging biologic patterns between these two arms, with the goal of identifying distinct pathways that are inhibited in each condition. These results, in turn, could provide insight to differences between phosphatase activation versus kinase inhibition. Results: KSEA profiling revealed distinct signaling responses between the two arms. Notably, the kinase inhibitors caused robust downregulation of the MAPK signaling pathway, whereas SMAP treatment showed limited involvement of that cascade. Thus, we hypothesized that a combination of SMAP + MEKi would yield enhanced anticancer response compared to either single agent. Subsequent murine xenograft testing demonstrated superior tumor response with SMAP + MEKi versus either compound alone. Conclusion: This project offers a phosphoproteomics-level glimpse to the signaling effects between phosphatase activation compared to kinase inhibition. The data, in turn, could be used for rational drug combination design to improve antitumor therapy. Citation Format: Danica D. Wiredja, Peter Liao, Jaya Sangodkar, Daniela Schlatzer, Mark R. Chance, Goutham Narla. Phosphoproteomics-guided anticancer drug combination design with a novel small-molecule PP2A activator [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2698.
End-to-end Phoneme Sequence Recognition using Convolutional Neural Networks (2013)

Most phoneme recognition state-of-the-art systems rely on a classical neural network classifiers, fed with highly tuned features, such as MFCC or PLP features. Recent advances in ``deep learning'' approaches questioned such systems, but while some attempts were made with simpler features such as spectrograms, state-of-the-art systems still rely on MFCCs. This might be viewed as a kind of failure from deep learning approaches, which are often claimed to have the ability to train with raw signals, alleviating the need of hand-crafted features. In this paper, we investigate a convolutional neural network approach for raw speech signals. While convolutional architectures got tremendous success in computer vision or text processing, they seem to have been let down in the past recent years in the speech processing field. We show that it is possible to learn an end-to-end phoneme sequence classifier system directly from raw signal, with similar performance on the TIMIT and WSJ datasets than existing systems based on MFCC, questioning the need of complex hand-crafted features on large datasets.
Abstract 2300: Insulin receptor kinase inhibition is better tolerated than hypoinsulinemia and more effective than metformin in treating breast cancer (2011)

Abstract Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin-responsive, but it is unclear if safe and effective therapies that target the insulin receptor can be developed. We demonstrate that both insulin receptor family tyrosine kinase inhibition and insulin deficiency have anti-neoplastic activity in a model of insulin-responsive breast cancer in mice metabolically normal at baseline. In contrast to insulin deficiency, insulin receptor inhibition does not lead to hyperglycemia and is well-tolerated. We show that pharmacokinetic factors explain the safety of receptor inhibition relative to ligand deficiency, as BMS-536924 does not accumulate in muscle at levels sufficient to block insulin-stimulated glucose uptake. Metformin, which lowers the elevated insulin levels present in settings of insulin resistance, had minimal activity in this model. The findings highlight the importance of tissue-specific drug accumulation as a determinant of efficacy and toxicity of tyrosine kinase inhibitors, and suggest that therapeutic targeting of the insulin receptor family for cancer treatment is practical. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2300. doi:10.1158/1538-7445.AM2011-2300
Efficacy Outcomes in the Phase 3 COMBI-AD Study of Adjuvant Dabrafenib Plus Trametinib vs Placebo in Patients with Stage III BRAFV600E/K-Mutant Melanoma (2018)

Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN
Consumer Evaluations of Mobile, Conversational Decision Aids for In-Store Shopping: Effects of Decision Strategy Implemented and Consumer Need for Cognition (2022)

In this paper, we examine the effects of an artificially intelligent, mobile, conversational decision aid’s strategy (attribute-/alternative-based) and consumers’ need for cognition (low/high) on decision elaboration, decision aid evaluations (perceived usefulness, enjoyment, attitude) and reuse intentions in a semi-realistic store. Based on consumer decision-making theory, the decision aid developed employed four decision strategies that consumers commonly use, two attribute-based (lexicographic, elimination-by-aspects) and two alternative-based (satisficing, weighted adding) differentiated by whether the decision support began by having consumers think about key attributes or alternatives (brands) for their choice. A total of 100 consumers were recruited for the consumer experiment employing a between-subjects design. The results demonstrated that attribute-based mobile decision aids are perceived to be more beneficial and lead to greater reuse intent in a physical retail store than alternative-based decision aids. Mobile decision aids are also evaluated more positively with respect to enjoyment and attitude by low-NFC (vs. high-NFC) consumers.
The Peripherally Inserted Central Catheter (PICC): A Prospective Study of its Natural History after Cubital Fossa Insertion (2002)

A prospective cohort study was undertaken to describe the natural history of the cubital fossa peripherally inserted central catheter (PICC), determine which factors influenced the hazard of complication and develop a standard methodology for evaluation of a PICC service. A total of 4349 patient days of PICC observation were analysed using survival analysis techniques. The median time to PICC removal for a complication was 60 days. The most common complications were phlebitis, malposition and tip migration. Complications usually occurred during the first week. There was only one episode of line-related sepsis. Size 3 French gauge catheters had a complication rate of 7.3 per 1,000 line days compared to 14.2 for 4 French catheters (hazard rate 1.26 90% CI 1.02 to 1.55). PICCs requiring two or more attempts at insertion were more likely to develop complications than those inserted at the first attempt: 20 per 1,000 line days vs 10.5 but the confidence intervals were wide (hazard rate 1.91, 90% CI 0.90 to 4.05). Operator (amongst the four experienced operators who inserted all PICCs), arm of placement, or medial or lateral placement in the cubitalfossa did not influence PICC survivaL