gebhart/patrepeval huggingface dataset:
DTN-based Content Storage and Retrieval (2007)

Delay-tolerant networking (DTN) enables nodes to communicate by means of asynchronous messaging witout the need for an end-to-end path. Suitably designed application protocols may operate in DTNs by minimizing end-to-end interactions and using self-contained messages for communication. The store-carry-and-forward operation and message replication of many DTN routing protocols may yield multiple copies of messages spread across many nodes for an axtended period of time. We leverage these properties for application support in (mobile) intermediate DTN nodes which act as ad-hoc routers. We add explicit application hints to messages that are visible to each node, allowing them, e.g., to cache content, act as distributed storage, or perform application-specific forwarding.
CLAMP: Active queue management at wireless access points (2005)

Abstract: This paper investigates the performance of CLAMP, a distributed algorithm to enhance the performance of TCP connections that terminate in a wireless access network. CLAMP works at a receiver to control a TCP sender by setting the TCP receiver’s advertised window limit. CLAMP provides explicit control over wireless link utilisation and queueing delay at the access point buffer, and can drastically increase the throughput of socalled short TCP flows with negligible loss in long TCP flow throughput. 1.
Dipolar donor–acceptor molecules in the cyanine limit for high efficiency green-light-selective organic photodiodes (2016)

Two novel dipolar donor–acceptor molecules approaching the cyanine limit were used for green-light-selective OPDs.
Convergence theorems for uniformly quasi‐Lipschitzian mappings (2004)

We prove some convergence theorems of the modified Ishikawa iterative sequence with errors for uniformly quasi‐Lipschitzian mappings in metric spaces. Our results generalize and improve the corresponding results of Petryshyn and Williamson, Ghosh and Debnath, Liu, and many others.
Role of Vascular Endothelial Growth Factor in Kidney Disease (2010)

Vascular endothelial growth factor (VEGF) is a main regulator of blood vessel growth and plays an important role in promoting endothelial survival and maintaining the microvasculature. The kidney is a highly vascularized organ and has two important microvasculatures; glomerular and peritubular capillaries. Loss of these capillaries is strongly associated with the progression of chronic kidney disease (CKD) to end-stage renal disease. In several kidney disease animal models, VEGF expression in the kidney is decreased and administration of VEGF is protective. Recent clinical observations revealed that blocking VEGF by endogenous inhibitor (soluble Flt-1) in preeclampsia and monoclonal antibody against VEGF in cancer patients cause proteinuria and renal dysfunction. However, plasma VEGF levels in diabetic nephropathy patients are increased and blocking VEGF improved diabetic nephropathy in animal models. Increased plasma VEGF levels have been reported in CKD patients. Deleterious effects of VEGF have been demonstrated in atherosclerosis and sepsis, which are frequent complications in CKD patients. Although administrating VEGF or novel drugs that activate VEGF pathway may improve the progression of CKD, careful monitoring will be required when CKD patients have complications of diabetes, atherosclerosis or sepsis.
Effect of cobalt on the anaerobic thermophilic conversion of methanol (2004)

The importance of cobalt on the anaerobic conversion of methanol under thermophilic conditions was studied in three parallel lab-scale UASB-reactors and in cobalt-limited enriched cultures. Reactors R1, R2, and R3 were fed with methanol in a bicarbonate-buffered medium, supplied with iron and macronutrients: in R1 all metals were supplied (control), R2 was cobalt deprived, and in R3 all metals were deprived. In the 136 days of continuous experiment, a drop in performance was observed over the last 30 days. Particularly in R3, both methanol removal and methane formation dropped by 7.1% and 13.7%, respectively, compared to the control reactor, R1. When the medium was cobalt-deprived, acetate was not produced and, as a consequence, the enriched consortium lost its capacity to degrade acetate, indicating that the acetotrophic microorganisms were washed out. The addition of 0.5 microM of cobalt to a cobalt-deprived enrichment culture led to acetate accumulation. The results obtained in this study indicate that the mixed consortium requires a proper amount of cobalt, and its addition to a concentration of 0.1 microM leads to the highest methanol conversion rate, with methane as the sole end product from methanol.
Investigation of volatile flavor compounds in fresh and ripened Domiati cheeses (1993)

The volatile compounds of three fresh and six 3-months-ripened Domiati cheeses were investigated with a dynamic headspace GC-MS system. Unlike the amino acid degradation products and the diketones, acrolein, propan-1-ol, butan- 2-one, butan-2-ol, and a large number of esters appear during maturation. Moreover, various sulfur compounds contribute significantly to the overall cheese aroma, particularly when bad ripening occurs. Most of the volatile compounds are synthesized after 2 months of maturation.
Memantine for Fragile X–Associated Tremor/Ataxia Syndrome (2013)

ClinicalTrials.gov identifier: NCT00584948.
Syntheses and Characterization of o‐Carboranes Containing Fused exo‐Polyhedral Di‐ and Triboraheterocycles (2013)

Abstract Reaction of dilithio‐ o ‐carborane Li 2 C 2 B 10 H 10 (generated in situ from o ‐carborane 1 and butyllithium) with the 1, 2‐diborylbenzene derivative 1, 2‐C 6 H 4 ( i Pr 2 NBCl) 2 yielded the o ‐carborane compound 3 having the fused exo ‐polyhedral C 2 B 2 C 2 heterocycle. The analogous reactions with 1, 1‐bis(dimethylaminochloroboryl)ethane and with 1, 3‐dichloro‐1, 2,3‐tris(dimethylamino)triborane(5) afforded the o ‐carborane compounds 5 and 7 containing the fused exo ‐polyhedral five‐membered C 2 B 2 C and C 2 B 3 rings, respectively. Attempts to use 1, 2‐dichloro‐1, 2‐bis(dimethylamino)diborane(4) for the synthesis of the o ‐carborane compound 10 with a fused exo ‐polyhedral C 2 B 2 ring instead led to the diborane(4)yl‐ o ‐carborane species 9c and 9d (the latter in trace amount), which contain a diborane(4)yl moiety bonded to the o ‐carborane. The molecular compositions of the new o ‐carborane derivatives follow from NMR spectroscopic and mass spectrometric data as well as from X‐ray diffraction analyses of 3 , 7 and 9c . The structures exhibit weak intramolecular C–H ··· H–B hydrogen‐hydrogen interactions.
SOLUÇÃO LOGÍSTICA PARA EXTRAVIOS DE BAGAGENS NOS AEROPORTOS (2016)

Os problemas relacionados a falta de cuidado com bagagens e uma das preocupacoes mais comuns e discutidas em conferencias da area de trafego aereo e grande parte dos aeroportos do mundo, e o Brasil tambem se inclui na discussao deste problema que a cada dia acarreta mais prejuizos, tanto para as companhias aereas como aos seus clientes. E importante observar esse tipo de problema ja que a logistica e parte importante para que o transporte de bagagens seja realizado de forma efetiva, assim evitando transtornos, perdas financeiras e oferecendo ao cliente um servico de qualidade. O objetivo do presente trabalho e estudar atraves de pesquisa de campo e material bibliografico as causas deste problema e apontar as possiveis solucoes, utilizando como ferramenta a Logistica Empresarial.
Laser Tissue Welding - Poised for the New Millenium. (2000)

Laser tissue welding is a relatively new technique, which was initially described only about 30 years ago. Over the past 10 years, the implementation of protein solders has redefined the field. Alternative methods of wound closure and of tissue approximation have been quickly accepted in clinical medicine. The techniques and theory involved in performing laser tissue welding may soon be essential knowledge for all surgeons. Just as laparoscopy has become a mainstay for general surgeons and urologists, novel mechanisms of tissue approximation will continue to replace older, less efficacious techniques.
A Fast-Locking Agile Frequency Synthesizer for MIMO Dual-mode WiFi / WiMAX Applications (2007)

In this paper, a frequency synthesizer based on phase-locked loop (PLL) technique for dual-mode WiFi (2.4-GHz band) and WiMax (5-GHz band) applications is presented. The frequency synthesizer with wide frequency range application and the settling time within 10-mus is realized by a time-to-voltage converter (TVC). A 40-MHz input reference for 125-KHz frequency steps which is realized by a 12-bits MASH 1-1 delta-sigma modulator for fractional divisions. The frequency synthesizer provides output frequency ranges from 4.6-GHz to 5.4-GHz with simulated phase noise of around -110 dBc/Hz at 1-MHz offset. Simulated in standard 0.13-μm CMOS process, the frequency synthesizer dissipates 40-mW from a 1.2-V power supply.
A methodological approach for algorithmic composition systems' parameter spaces aesthetic exploration (2016)

Algorithmic composition is the process of creating musical material by means of formal methods. As a consequence of its design, algorithmic composition systems are (explicitly or implicitly) described in terms of parameters. Thus, parameter space exploration plays a key role in learning the system's capabilities. However, in the computer music field, this task has received little attention. This is due in part, because the produced changes on the human perception of the outputs, as a response to changes on the parameters, could be highly nonlinear, therefore models with strongly predictable outputs are needed. The present work describes a methodology for the human perceptual (or aesthetic) exploration of generative systems' parameter spaces. As the systems' outputs are intended to produce an aesthetic experience on humans, audition plays a central role in the process. The methodology starts from a set of parameter combinations which are perceptually evaluated by the user. The sampling process of such combinations depends on the system under study and possible on heuristic considerations. The evaluated set is processed by a compaction algorithm able to generate linguistic rules describing the distinct perceptions (classes) of the user evaluation. The semantic level of the extracted rules allows for interpretability, while showing great potential in describing high and low-level musical entities. As the resulting rules represent discrete points in the parameter space, further possible extensions for interpolation between points are also discussed. Finally, some practical implementations and paths for further research are presented.
A Novel HMG A-Like Protein Binds Differentially to the AT-Rich Regions Located in the Far Distal and Proximal Parts of a Soybean Glutamine Synthetase Gene (GS15) Promoter (2002)

In soybean (Glycine max L.) ammonium provided externally or as the result of symbiotic nitrogen fixation stimulates the transcription of GS15, a gene encoding cytosolic glutamine synthetase. Strong constitutive positive expression (SCPE), silencer-like and organ-specific elements, located respectively in the distal, the central and the proximal region of the promoter are required to control the ammonium responsiveness of the gene expression [Tercé-Laforgue et al. (1999) Plant Mol. Biol. 39: 551]. It was hypothesized that the correct spatial conformation of the promoter permitted the cooperative action of these three cis-acting elements. Further investigations were therefore required to ascertain this hypothesis. A nodule nuclear protein, binding to a 66 bp AT-rich DNA fragment containing a 13 bp AT-rich repeated sequence (AT-1) and located just downstream of the SCPE element, was identified using a gel retardation assay. A cDNA clone likely to code for this protein was isolated using the yeast one-hybrid system. It encodes a novel DNA binding protein (AT-1SNBP) similar to HMG A proteins but exhibiting a higher molecular weight. AT-1SNBP appears to be encoded by a single gene that is expressed in roots, root nodules and leaves of soybean. Since two other 13 bp AT-rich repeated sequences (AT-2 and AT-3) were localized in the organ-specific element, we have quantified the binding affinity of AT-1SNBP to these sequences. We demonstrate that AT-1SNBP binds differentially to DNA fragments containing AT-1, AT-2 and AT-3 and that its binding affinity depends on the presence of adjacent sequences. This result suggests that AT-1SNBP may be an architectural protein involved in maintaining the spatial conformation of the GS15 promoter, thus facilitating the interaction between the distal and proximal regulatory elements.
Channel Coding for Future Space Missions: New Requirements and Trends (2007)

Future space missions will put severe constraints on communication links in terms of data rates, bandwidth occupancy, complexity, and performance. The requirements imposed by the new missions and their consequences on channel code design are presented in the first part of the paper. All relevant issues, including code rates, frame lengths, modulation formats, performance metrics, complexity, and others, are discussed. In the second part of the paper, long erasure correcting codes are presented and their properties explained. These codes operate at the upper layers of the space link protocol and constitute an attractive new frontier for zero packet loss in future space communications.
MODELLIERUNG VON BANDSTRUKTUREN BEI DER CT-BILD-BASIERTEN PLANUNG KNIEENDOPROTHETISCHER EINGRIFFE (2002)

Article MODELLIERUNG VON BANDSTRUKTUREN BEI DER CT-BILD-BASIERTEN PLANUNG KNIEENDOPROTHETISCHER EINGRIFFE was published on January 1, 2002 in the journal Biomedical Engineering / Biomedizinische Technik (volume 47, issue s1a).
Abstract B105: Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival (2009)

Abstract Metastasis underlies the majority of cancer-related deaths. Hence, furthering our understanding of the molecular mechanisms that enable tumor cell dissemination is a vital health issue. Epithelial-to-mesenchymal transitions (EMT) endow carcinoma cells with enhanced migratory and survival attributes that facilitate malignant progression. Characterization of EMT effectors is likely to yield new insights into metastasis and novel avenues for treatment. We show that the presence of the receptor tyrosine kinase Axl in mammography-detected primary breast cancers independently predicts strongly reduced overall patient survival, and matched patient metastatic lesions show enhanced Axl expression. We demonstrate that Axl is strongly induced by epithelial-to-mesenchymal transition in pre-malignant mammary epithelial cells that establishes an autocrine signaling loop with its ligand, Gas6. Using epi-allelic RNA interference analysis in metastatic breast cancer cells we delineated a distinct threshold of Axl expression for mesenchymal-like in vitro cell invasiveness, and to form tumors in foreign and tissue engineered microenvironments in vivo. Importantly, Axl knockdown completely prevented the spread of highly metastatic breast carcinoma cells from the mammary gland to lymph nodes and several major organs, and increased overall survival, in two different optical imaging-based experimental breast cancer models. Thus, Axl represents a novel downstream effector of tumor cell EMT that is required for breast cancer metastasis. The detection and targeted treatment of Axl-expressing tumors represents an important new therapeutic strategy for breast cancer. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):B105.
High-voltage management in single-supply CHE nor-type flash memories (2003)

In a flash memory, a number of voltage levels different from V/sub DD/ are needed to perform the required operations (read, program, and erase) on the array cells. In the case of single-supply memory devices, voltages higher than V/sub DD/ as well as negative voltages, which are referred to as high voltages (HVs), must be produced on-chip. This paper aims at giving the reader an overview of how HVs are generated and managed in single-supply NOR-type flash memories programmed by channel hot-electron injection. Both schemes used for conventional (i.e., bilevel) memory devices and schemes designed to meet multilevel memory requirements are addressed.
Robust Multitarget Tracking in Forward-Looking Sonar Image Sequences Using Navigational Data (2012)

This paper presents a new approach to the problem of tracking objects in sequences of forward-looking sonar images. Unlike previous work, navigational data are taken as inputs to the state model of the Kalman filter used for tracking fixed obstacles. This model allows a robust prediction of their apparent motion in relation to the position of the sonar. A complete framework is presented where detection and data association issues are also discussed. An assessment of the proposed method has been carried out on real data from two different systems. Moreover, whereas the state model was first derived for a ground obstacle, a modified state model is proposed to estimate the altitude of the obstacle in relation to the sonar position using a number of successive pings.
Angiotensin II induces transport of cytoplasmic lipoxygenase proteins to actin fibers (2001)

We have previously reported that angiotensin-II increases the formation of 12- and 15- hydroxyeicosatetraenoic acid (HETE) in cultured human umbilical artery smooth muscle cells (VSMC). We further reported that 12-lipoxygenase (LO) inhibitors block angiotensin-II induced vasoconstriction invitro and in vivo and lower blood pressure in SHR and renovasailor hypertensive rats. To gain insights into the mechanisms underlying these effects we set out to localize the 12LO protein in primary human arterial tissue and VSMC. First, we characterized the expression of a human platelet type 12LO mRNA in VSMC. Second, we developed a polyclonal antibody directed to a 24 amino acid peptide corresponding to exon 4 region of the expressed 12LO gene. Third, upon Western analysis of protein extracts derived from vascular human placental artery smooth muscle cells (VSMC), bands of 74 (major), 62 (major), 110 (minor) and 34 kDa were visualized. Fourth, immuno-histochemical analysis of these same cells in culture or within whole placental artery or cultured human mammary artery smooth muscle cells showed a clear cytoplasmic localization. Fifth, on electron microscopy using the affinity-purified exon 4, 12-LO antibody with immunogold, 12-LO was found primarily localized between the cytoplasmic muscle fibrils of VSMC, but not in the body of the nucleus, mitochondria and endoplasmic recticulim. Finally, upon angiotensin-II treatment of cultured VSMC, 12-LO was found by immunoprecipitation, to bind to α-actin, a component of the cytoplasmic muscle fibrils, which was blocked by pretreatment of with the 12-LO inhibitors, baicalien or esculetine. Angiotensin-II also decreased the association of 15-LO (type 2) with α-actin, albeit with different kinetics. Moreover, the dissociation of 15-LO, but not the binding of 12-LO to α-actin coincided with the tyrosine phosphorylation of this protein. In summary, cytoplasmic juxtafibrillar LO proteins associate with α-actin in response to angiotensin-II which can be blocked by LO inhibitors. These observations suggest a previously unrecognized association between angiotensin-II dependent vasoconstriction, LO protein- α-actin interactions and fatty acid oxidation in human VSMC.
Real-time mass-spectrometric screening of droplet-scale electrochemical reactions (2018)

A droplet-scale, real-time electrochemical reaction screening platform based on droplet spray ionization mass spectrometry (DSI-MS) has been developed. The N,N-dimethylaniline (DMA) radical cation with a half-life of microseconds was readily detected by MS during the electrooxidation of DMA, and the subsequent reactions were followed in real time for minutes.
Comparative mapping of bovine chromosome 27 with human chromosome 8 near a dairy form QTL in cattle (2005)

In the absence of a complete and annotated bovine genome sequence, detailed human-bovine comparative maps are one of the most effective tools for identification of positional candidate genes contributing to quantitative trait loci (QTL) in cattle. In the present study, eight genes from human chromosome 8 were selected for mapping in cattle to improve breakpoint resolution and confirm gene order on the comparative map near the 40 cM region of the BTA27 linkage map where a QTL affecting dairy form had previously been identified. The resulting map identified ADRB3 as a positional candidate gene for the QTL contributing to the dairy form trait based on its estimated position between 40 and 45 cM on the linkage map. It is also a functional candidate gene due to its role in fat metabolism, and polymorphisms in the ADRB3 gene associated with obesity and metabolic disease in humans, as well as, carcass fat in sheep. Further studies are underway to investigate the existence of polymorphisms in the bovine ADRB3 gene and their association with traits related to fat deposition in cattle.
Meet Olivier de Weck (2012)

INSIGHT is the magazine of the International Council on Systems Engineering. It is published four times per year and features informative articles dedicated to advancing the state of practice in systems engineering and to close the gap with the state of the art. INSIGHT delivers practical information on current hot topics, implementations, and best practices, written in applications-driven style.
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche (2020)

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation2,3, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P<5×10−8) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1/WDR25, MKRN3/MAGEL2 and KCNK9) demonstrating parent-of-origin specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and gamma-aminobutyric acid-B2 receptor signaling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.