gebhart/patrepeval huggingface dataset:
Abstract 2449: The bromodomain inhibitor JQ1 blocks growth of pancreatic cancer cells in 3D collagen. (2013)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich stromal reaction that has been shown to contribute to chemo-resistance. We have found that the collagen microenvironment promotes expression of histone acetyltransferases (HATs) and thereby promotes chemo-resistance; however, HATs have proven to be difficult ‘druggable’ targets. Bromodomain proteins are chromatin readers that can bind to acetylated histones and thereby regulate gene expression. JQ1, an inhibitor of BET class of human bromodomains, was shown to have efficacy against leukemia and lymphoma cell lines. Thus, we examined the effect of JQ1 on a panel of PDAC cells grown in 3D collagen. AsPC1, CD18 and Panc02.03 cells were particularly sensitive to the effects of JQ1, while Panc1 cells were relatively resistant to JQ1 treatment. JQ1 decreased myc mRNA and increased p21 mRNA in CD18 cells, but not in Panc1 cells. JQ1 also decreased growth of chemo-resistant CD18 cells grown in 3D collagen, and blocked EGF and TGF-β1-induced growth and scattering of Panc1 and CD18 cells in 3D collagen. The MEK1/2 inhibitor U0126 and JQ1 synergistically attenuated growth of CD18 and Panc1 cells in 3D collagen. In addition, EGFR inhibitors (AG1478 and PD153035) and JQ1 also synergistically attenuated the growth of CD18 and Panc1 cells in 3D collagen. In contrast, the p38 MAPK inhibitor SB202190 did not attenuate the effect of JQ1 on growth of CD18 and Panc1 cells in 3D collagen. Finally, JQ1 potentiated the effect of gemcitabine on the growth of CD18 and Panc1 cells in 3D collagen. Overall, these results suggest that JQ1 and other bromodomain inhibitors are potential therapeutic agents for the treatment of pancreatic cancer. Citation Format: Vaibhav Sahai, Krishan Kumar, Kazumi Ebine, Halla Nimeiri, Hidayatullah G. Munshi. The bromodomain inhibitor JQ1 blocks growth of pancreatic cancer cells in 3D collagen. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2449. doi:10.1158/1538-7445.AM2013-2449
QACE: Asking Questions to Evaluate an Image Caption (2021)

In this paper, we propose QACE, a new metric based on Question Answering for Caption Evaluation. QACE generates questions on the evaluated caption and checks its content by asking the questions on either the reference caption or the source image. We first develop QACE Ref that compares the answers of the evaluated caption to its reference, and report competitive results with the state-of-the-art metrics. To go further, we propose QACE Img , which asks the questions directly on the image, instead of reference. A Visual-QA system is necessary for QACE Img . Unfortunately, the standard VQA models are framed as a classification among only a few thousand categories. Instead, we propose Visual-T5, an abstractive VQA system. The resulting metric, QACE Img is multi-modal, reference-less, and explainable. Our experiments show that QACE Img compares favorably w.r.t. other reference-less metrics. We will release the pre-trained models to compute QACE.
Fluorescence Pattern Analysis-How To Achieve a Better Quality-Standard? (2017)

Quantitative imaging of fluorescent proteins and patterns is accomplished with a variety of techniques, including wide-field, confocal and multiphoton microscopy, ultrafast low-light level digital cameras and multi tracking laser control systems. These microscopic images can be of 2-dimensional or 3-dimensional nature, or even 4-dimensional nature such as videos recording the life cycle of a cell. To make fluorescent pattern analysis feasible in daily practice in cellular and molecular biology as well as in medicine, agriculture or other applications standardization is necessary to obtain authentically and reproducible results. We describe in this article the important steps that are necessary to support standardization.
CMOS Digital Integrated Circuits Analysis & Design (1995)

CMOS Digital Integrated Circuits: Analysis and Design is the most complete book on the market for CMOS circuits. Appropriate for electrical engineering and computer science, this book starts with CMOS processing, and then covers MOS transistor models, basic CMOS gates, interconnect effects, dynamic circuits, memory circuits, BiCMOS circuits, I/O circuits, VLSI design methodologies, low-power design techniques, design for manufacturability and design for testability. 
This book provides rigorous treatment of basic design concepts with detailed examples. It typically addresses both the computer-aided analysis issues and the design issues for most of the circuit examples. Numerous SPICE simulation results are also provided for illustration of basic concepts. Through rigorous analysis of CMOS circuits in this text, students will be able to learn the fundamentals of CMOS VLSI design, which is the driving force behind the development of advanced computer hardware.
Table of contents

1 Introduction
2 Fabrication of MOSFETS
3 MOS Transistor
4 Modeling of MOS Transistors Using SPICE
5 MOS Inverters: Static Characteristics
6 MOS Inverters: Switching Characteristics and Interconnect Effects
7 Combinational MOS Logic Circuits
8 Sequential MOS Logic Circuits
9 Dynamic Logic Circuits
10 Semiconductor Memories
11 Low-Power CMOS Logic Circuits
12 BiCMOS Logic Circuits
13 Chip Input and Output (I/O) Circuits
14 Design for Manufacturability
15 Design for Testability
Ocular drug delivery – a look towards nanobioadhesives (2010)

The importance of and need for new developments in the field of ocular nanobioadhesives is emphasized.
Novel Adaptive Nonlinear Predistorters Based on the Direct Learning Algorithm (2006)

The adaptive nonlinear predistorter is an effective technique to compensate for the nonlinear distortion existing in digital communication and control systems. However, available adaptive nonlinear predistorters using indirect learning are sensitive to measurement noise and do not perform optimally. Other available types are either slow to converge, complicated in structure and computationally expensive, or do not consider the memory effects in nonlinear systems such as a high power amplifier (HPA). In this paper, we first propose several novel adaptive nonlinear predistorters based on direct learning algorithms - the nonlinear filtered-x RLS (NFXRLS) algorithm, the nonlinear adjoint LMS (NALMS) algorithm, and the nonlinear adjoint RLS (NARLS) algorithm. Using these new learning algorithms, we design adaptive nonlinear predistorters for an HPA with memory effects or for an HPA following a linear system. Because of the direct learning algorithm, these novel adaptive predistorters outperform nonlinear predistorters that are based on the indirect learning method in the sense of normalized mean square error (NMSE), bit error rate (BER), and spectral regrowth. Moreover, our developed adaptive nonlinear predistorters are computationally efficient and/or converge rapidly when compared to other adaptive nonlinear predistorters that use direct learning, and furthermore can be easily implemented. We further simplify our proposed algorithms by exploring the robustness of our proposed algorithm as well as by examining the statistical properties of what we call the "instantaneous equivalent linear" (IEL) filter. Simulation results confirm the effectiveness of our proposed algorithms
Applications of Chitosan in Fuel Cells (2022)

Polymer electrolyte membranes play an important role in a fuel cell. Chitosan-based polyelectrolyte membrane can be used in fuel cells as a substitute for conventional Nafion membrane. This chapter discusses the types of different fuel cells and the performance of various chitosan-based polyelectrolyte membranes in fuel cells.
Enhanced osteogenesis on titanium implants by UVB photofunctionalization of hydrothermally grown TiO2 coatings (2015)

Even though Ti-based implants are the most used materials for hard tissue replacement, they may present lack of osseointegration on the long term, due to their inertness. Hydrothermal treatment (HT) is a useful technique for the synthesis of firmly attached, highly crystalline coatings made of anatase titanium dioxide (TiO2), providing favorable nanoroughness and higher exposed surface area, as well as greater hydrophilicity, compared to the native amorphous oxide on pristine titanium. The hydrophilicity drops even more by photofunctionalization of the nanostructured TiO2-anatase coatings under UV light. Human mesenchymal stem cells exhibited a good response to the combination of the positive surface characteristics, especially in respect to the UVB pre-irradiation. The results showed that the cells were not harmed in terms of viability; even more, they were encouraged to differentiate in osteoblasts and to become osteogenically active, as confirmed by the calcium ion uptake and the formation of well-mineralized, bone-like nodule structures. In addition, the enrichment of hydroxyl groups on the HT-surfaces by UVB photofunctionalization accelerated the cell differentiation process and greatly improved the osteogenesis in comparison with the nonirradiated samples. The optimal surface characteristics of the HT-anatase coatings as well as the high potentiality of the photo-induced hydrophilicity, which was reached during a relatively short pre-irradiation time (5 h) with UVB light, can be correlated with better osseointegration ability in vivo; among the samples, the superior biological behavior of the roughest and most hydrophilic HT coating makes it a good candidate for further studies and applications.
Efficient virtual network isolation in multi-tenant data centers on commodity ethernet switches (2016)

Infrastructure-as-a-Service providers need to provision and isolate their tenants's virtual networks. Current network isolation solutions either suffer from limited scalability, incur encapsulation overheads, or require advanced (e.g., OpenFlow) hardware switches. We propose LANES, a system that provides isolation between billions of virtual machines using commodity Ethernet switches without encapsulation overheads. LANES virtualizes each tenant's network address space and configures rules on each server to translate (tenant) virtual addresses to (infrastructure) physical addresses. Virtual address spaces give tenants flexibility when configuring their virtual networks, and physical addresses reduce demand on infrastructure switches. We implement LANES in OpenStack, leveraging OpenStack's network description functionalities and using OpenFlow to configure Open vSwitch on infrastructure servers. Our evaluation shows LANES ensures network isolation with acceptable rule configuration latency.
Energy Management of a Fuel-Cell Serial–Parallel Hybrid System (2015)

In this paper, a serial-parallel hybrid (SPH) power system formed by a fuel cell (FC), an auxiliary storage device (ASD), and the current-controlled dc-dc converters responsible for the power management are realized by using the digital signal controller (DSC) TMS32F28335. The main energy management goal is to transfer energy from the sources (FC or ASD) to the load while ensuring dc bus voltage regulation and high power conversion efficiency. In addition, a safe and reliable operation of the system has to be achieved. The selected converter and its controller features are noninverting voltage step up and step down, high efficiency, regulation of input and output currents and low ripple values, and the ability to change from input to output current regulation loop, suddenly and smoothly, and vice versa. All these features allow it to be positioned in different FC system localizations and simplify the design of the master control. Simulation and experimental results have been validated on a 48-V 1200-W dc bus.
Reliability of the Cerebral Performance Category to classify neurological status among survivors of ventricular fibrillation arrest: a cohort study (2011)

In this cohort study of survivors of out-of-hospital ventricular fibrillation cardiac arrest, the use of the CPC to classify favorable versus unfavorable neurological status at hospital discharge produced variable inter- and intra-reviewer agreement. The findings provide useful context to interpret outcome evaluations that report CPC.
Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1 (2013)

The family Iridoviridae consists of 5 genera of double-stranded DNA viruses, including the genus Megalocytivirus, which contains species that are important fish pathogens. In a previous study, we isolated the first rock bream iridovirus from China (RBIV-C1) and identified it as a member of the genus Megalocytivirus. In this report, we determined the complete genomic sequence of RBIV-C1 and examined its in vivo expression profiles. The genome of RBIV-C1 is 112333 bp in length, with a GC content of 55% and a coding density of 92%. RBIV-C1 contains 4584 simple sequence repeats, 89.8% of which are distributed among coding regions. A total of 119 potential open reading frames (ORFs) were identified in RBIV-C1, including the 26 core iridovirus genes; 41 ORFs encode proteins that are predicted to be associated with essential biological functions. RBIV-C1 exhibits the highest degree of sequence conservation and colinear arrangement of genes with orange-spotted grouper iridovirus (OSGIV) and rock bream iridovirus (RBIV). The pairwise nucleotide identities are 99.49% between RBIV-C1 and OSGIV and 98.69% between RBIV-C1 and RBIV. Compared to OSGIV, RBIV-C1 contains 11 insertions, 13 deletions, and 103 single nucleotide mutations. Whole-genome transcription analysis showed that following experimental infection of rock bream with RBIV-C1, all but 1 of the 119 ORFs were expressed at different time points and clustered into 3 hierarchical groups based on their expression patterns. These results provide new insights into the genetic nature and gene expression features of megalocytiviruses.
Airway Reactivity Induced Reversible Voice Dysfunction in Singers (1997)

As the power source for vocalization, the lower respiratory tract plays a key role in voice production. This is particularly true with sustained singing, where continued high ventilatory demands are present. Changes in pulmonary function that are insignificant with normal speech have been shown to lead to performance impairment. The purpose of this study was to examine and characterize this problem in a large group of singers. Systematic evaluation of a defined population, along with inhalational and singing challenge, was the design. The demographic characteristics, history, pulmonary function, and response to treatment were evaluated in 20 professional or serious amateur singers with voice problems, who did not have causal laryngeal pathology, whose history and evaluation suggested increased airway reactivity, and who responded to anti-asthma therapy. An additional patient was challenged by the exercise of singing in the office, with pulmonary function measurements before and after. This group of serious singers demonstrated vocalization complaints referable to bronchodilator responsive airway obstruction. They responded to treatment for asthma, with improvement in their performance-related difficulties. An additional subject demonstrated a small decline in expiratory flow rates with only 20 minutes of singing in the office. This was readily reversed by an inhaled bronchodilator. Singers who present with complaints of impaired vocalization, such as vocal fatigue, decreased control, and excessive muscular tension, should be evaluated for increased airway reactivity as a possible cause of their complaints.
Prevention and diagnostics of haemolytic disease of the fetus and newborn (2012)

Haemolytic disease of the newborn (HDN), also known as haemolytic disease of the fetus and newborn (HDFN), develops in the fetus when erythrocyte alloantibodies produced by the mother pass through the placenta. Severe form of HDFN is mainly caused by anti-D antibodies, but it can also be caused by many other types of antibodies, most often by anti-Kell (anti-K), anti-c, anti-E in anti-C. In order to prevent sensitisation to erythrocyte antigens, every pregnant woman is tested for blood group AB0, D, K and for irregular antibodies (IAT–indirect antiglobulin test). For D-negative women IAT is repeated in the 28th week of pregnancy, followed by an injection of anti-D immnunoglobulin (Ig anti-D) when indicated. At the Blood Transfusion Centre of Slovenia, we have recently started to determine the fetal D status from a maternal blood sample in order to avoid the unnecessary application of Ig anti-D to women bearing Dnegative fetuses.
Supplementary Figures from Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies (2023)

&lt;p&gt;Supplementary Figure S1-S7&lt;/p&gt;
Lymphadenitis caused by non-tuberculous mycobacteria in a university hospital in Taiwan: predominance of rapidly growing mycobacteria and high recurrence rate. (2005)

This study found that both previously healthy children and adults were susceptible to NTM lymphadenitis. RGM was the most common etiology rather than MAC among NTM species causing lymphadenitis. Inadequate surgical excision of the diseased lymph nodes and insufficient coverage of antimycobacterial therapy both contributed to the high recurrence rate.
Tandem iodine-mediated oxidations of tetrahydro-β-carbolines: total synthesis of eudistomins Y1–Y7 (2013)

An efficient iodine-mediated oxidation of tetrahydro-β-carbolines is described to yield aromatic β-carboline products with tandem C-H oxidation. The utility of the method was demonstrated in total syntheses of the alkaloids eudistomins Y1-Y7.
B103 Performance Improvement of Adsorption Chillers by the Optimization of Adsorption and Desorption Time (2008)

The purpose of the research is to enhance the average cooling capacity during a cycle by a new cycle time allocation. In the study, the performance of the single stage adsorption refrigeration cycle with the new cycle time allocation was predicted by simulation. The specific cooling capacity (SCC) and the coefficient of performance (COP) were compared with those of the cycle with conventional cycle time allocation. The optimization of the cycle time was performed using the particle swarm optimization. The optimum cycle time of the new cycle time allocation at each hot water temperature was obtained and it was compared with the optimum performance by the conventional cycle time allocation. The results showed that the new cycle time allocation would improve the SCC of the single stage adsorption cycle due to the prolonged adsorption time.
Suppl FigS6 from The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications (2023)

&lt;p&gt;Suppl FigS6&lt;/p&gt;
Correlation of Placental Magnetic Resonance Imaging With Histopathologic Diagnosis: Detection of Aberrations in Structure and Water Diffusivity (2019)

Diffusion- and T<sub>2</sub>-weighted MRI can potentially be used to detect significant placental pathology by using T<sub>2</sub> relaxation time and ADC as markers of altered placental microstructure.
Systems Approach to Fluid Sampling for Real-Time Testing without Sticking (2014)

Abstract Downhole fluid samples enable better quantification of condensate-to-gas ratios that are required for effective reservoir estimation and forecasting. Quality of samples directly affect the measured properties, i.e., fluid compressibility and viscosity, that provide the supplemental information necessary for planning prospective wells through improved understanding of the reservoir. An industry-leading, logging-while-drilling (LWD) fluid analysis and sampling tool was successfully deployed on 21 jobs with 46 runs to date, and completed 400 pressure tests with 109 samples recovered worldwide in shelf and deepwater projects. This paper highlights a new systems application for this technology to acquire single-phase fluid samples for a major operator in Trinidad. The acquired data was used for early investigation of reservoir connectivity. The technology was introduced to the oil and gas industry in 2011. High sample quality, testing without sticking, and sample acquisition in complex well geometries and designs differentiates this technology for fluid analysis and sampling from existing wireline alternatives. Benefits of the LWD method include improved cleanup time due to reduced invasion, reduced overall sample acquisition costs, and reduced risk of stuck pipe. This method enables sampling in extended-reach wells and enables accurate fluid identification of oil, gas or water. This paper describes the learning and the innovative systems methodology employed to successfully attain information pertinent to evaluating and understanding reservoirs.
Advanced Portable Differential Image Motion Monitor (2000)

Abstract : Atmospheric turbulence severely limits the resolution attainable with most astronomical imaging systems, yet quantitative characterization of turbulence conditions remains a difficult and expensive proposition. The goal of this project was to demonstrate that a dual aperture instrument could be constructed, primarily from commercial off-the-shelf (COTS) components, to serve as an inexpensive, easy to operate, seeing monitor. To this end, Mechanical & Composite Engineering (MCE) designed, integrated, tested, and delivered a dual aperture Differential Image Motion Measurement (DIMM) system. The system features high frame rate CCD cameras, a portable computer controlled tracking mount, and easy to use software running on a personal computer under the Windows NT operating system. Among the unique features of this system are a variable spacing between the sub-apertures, and independent frame rate and exposure time control of the CCD cameras. Standard output includes the transverse coherence length and the variance of the angle of arrival for each sub-aperture.
CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma (2015)

We conclude that CD57+ T-cells are TFH cells and form a subpopulation of TFH cells in tonsils and NLPHL.
Analysis of Disorder of Motor Image by Prediction of Reaching Distance in Hemiplegic Patients with Cerebrovascular Accident (2009)

［目的］脳卒中片麻痺患者における運動イメージの障害について，到達運動の予測距離を用いて検討した。［対象］片麻痺患者9名，健常高齢者10名，健常成人9名を対象とした。［方法］体幹の運動を伴わない上肢運動で到達可能と判断される距離（予測距離）を21方向で測定した。こうして測定した予測距離と上肢長（肩峰～中指先端）の差（絶対値）を上肢長で除した値（誤差率）について解析した。［結果］1）片麻痺患者の麻痺側による誤差率と非麻痺側による誤差率には差が認められず，2）片麻痺患者におけるこれらの誤差率は，健常成人および健常高齢者に比べて有意に高いことが明らかにされた。［結論］片麻痺患者は麻痺側にとどまらず非麻痺側にも運動イメージの障害を有することが強く示唆された。