gebhart/patrepeval huggingface dataset:
Marijuana Use and Abuse in Psychiatric Outpatients (1989)

AbstractEighty consecutive psychiatric outpatients, aged 18 to 30, were systematically evaluated regarding psychiatric diagnosis, marijuana use and abuse, alcohol abuse, and drug abuse. Twenty-eight were classified as marijuana abusers. They had an average of eight problems from marijuana use, including health problems, work problems, arrests, fighting, and inability to control marijuana use. Abusers began using marijuana at an earlier age, used marijuana more frequently, and combined marijuana with other drugs or alcohol more frequently than nonabusers. Abusers also had a higher incidence of alcohol abuse and substance abuse. Major depression was also present in a majority of marijuana abusers. Marijuana abuse and abuse of other substances were frequently overlooked in these psychiatric outpatients.
Retrieval of Slant Water Vapor Path and Slant Liquid Water from Microwave Radiometer Measurements during the DYNAMO Experiment (2015)

Observations during the Dynamics of the Madden-Julian Oscillation (DYNAMO) experiment focused on sensing atmospheric parameters, including vertical moisture profiles, cloud structure, precipitation processes, and planetary boundary layer properties, all of which are important for understanding and modeling the Madden-Julian Oscillation (MJO). These observations were performed using a variety of in-situ and remote sensors, including the S-band polarimetric and Ka-band (S-PolKa) radar, deployed by the National Center for Atmospheric Research (NCAR), and a colocated University of Miami microwave radiometer (UM-radiometer) operating at 23.8 and 30.0 GHz. These instruments sampled approximately the same volumes of the atmosphere at a variety of azimuth and elevation angles. The principal goal of this study is to develop a new retrieval strategy to estimate slant water vapor path (SWP) and slant liquid water (SLW) using UM-radiometer measurements from zenith to low elevation angles at a variety of azimuth angles. Retrievals of SWP along the radar signal path help to determine the error in radar reflectivity due to water vapor absorption. The retrieval algorithm has been developed using the vapor-liquid water ratio (VLWR) as well as both modeled and measured brightness temperatures for zenith to low elevation angles. Observation system simulation experiment (OSSE) results and measured radiosonde data have been used to determine that the retrieval uncertainty is less than 5% for integrated water vapor (IWV) and less than 12% for integrated liquid water (ILW). OSSE results for SWP show that the retrieval uncertainty is less than 8% at 5° elevation angle and less than 5% at 7° and 9°, while the mean difference between SWP retrieved from radiometer measurements and those retrieved from the S-PolKa radar during the DYNAMO campaign is less than 10% at 5° elevation angle and less than 7.5% at 7° and 9°. OSSE results for SLW show that the mean error is less than 24% for 5° elevation angle and less than 18% for 7° and 9°. Such retrievals of SWP and SLW help to characterize the distribution of water vapor and liquid water in the lower troposphere, which in turn may contribute to improvements in forecasting of convective initiation and precipitation.
LAP2α and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly (2004)

Lamina-associated polypeptide (LAP) 2alpha is a LEM (lamina-associated polypeptide emerin MAN1) family protein associated with nucleoplasmic A-type lamins and chromatin. Using live cell imaging and fluorescence microscopy we demonstrate that LAP2alpha was mostly cytoplasmic in metaphase and associated with telomeres in anaphase. Telomeric LAP2alpha clusters grew in size, formed 'core' structures on chromatin adjacent to the spindle in telophase, and translocated to the nucleoplasm in G1 phase. A subfraction of lamin C and emerin followed LAP2alpha to the core region early on, whereas LAP2beta, lamin B receptor and lamin B initially bound to more peripheral regions of chromatin, before they spread to core structures with different kinetics. Furthermore, the DNA-crosslinking protein barrier-to-autointegration factor (BAF) bound to LAP2alpha in vitro and in mitotic extracts, and subfractions of BAF relocalized to core structures with LAP2alpha. We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly.
INNOVATIVE TECHNOLOGY FOR SUSTAINABLE NEW MATERIALS (2016)

Active Cross-Linking agents (ACL) are a class of compounds used as activators for a wide range of reactions which aim to make covalent bonds without leaving trace in the final product. Crossing S.r.l., an Innovative Start Up, made a study to synthesize and test a new type of ACL for different manufacturing processes. In particular, a process was developed for the tanning of hides, allowing the making of a stable and metal-free leather with a deep focus to the environmental sustainability. Furthermore a second process for the production of active packaging by ACL is reported preventing the alteration of food, thanks to the complete, or partial, removal of preservatives and allowing a concrete solution to allergenic and intolerance problems. With this study Crossing S.r.l wants to demonstrate the possibility to produce good quality leather or offering an alternative to the use of preservatives with a highly sustainable protocols.
Two-Dimensional Topological Crystalline Insulator and Topological Phase Transition in TlSe and TlS Monolayers (2015)

The properties that distinguish topological crystalline insulator (TCI) and topological insulator (TI) rely on crystalline symmetry and time-reversal symmetry, respectively, which encodes different bulk and surface/edge properties. Here, we predict theoretically that electron-doped TlM (M = S and Se) (110) monolayers realize a family of two-dimensional (2D) TCIs characterized by mirror Chern number CM = -2. Remarkably, under uniaxial strain (≈ 1%), a topological phase transition between 2D TCI and 2D TI is revealed with the calculated spin Chern number CS = -1 for the 2D TI. Using spin-resolved edge states analysis, we show different edge-state behaviors, especially at the time reversal invariant points. Finally, a TlBiSe2/NaCl quantum well is proposed to realize an undoped 2D TCI with inverted gap as large as 0.37 eV, indicating the high possibility for room-temperature observation.
Somatic mutations of EGFR signal transducers and expression of tumor suppressor PTEN in biliary tract carcinoma (2007)

4582 Background: Biliary tract carcinomas express EGFR and are potential candidates to EGFR target therapies. We recently described somatic mutations of EGFR that can enhance MAPK or Akt activation (Clin Cancer Res, 2006). Some of them are identical to those previously reported to confer sensitivity to some tyrosine kinase inhibitors (TKIs) like erlotinib or gefitinib in lung cancer. Here we report a molecular analysis of EGFR transducers potentially involved in TKI response. Methods: In 49 samples of biliary tract carcinoma we performed mutational analysis of exons from 18 to 21 of EGFR, exons 9 and 20 of phosphatidylinositol 3’-kinase (PI3K), exon 2 of K-Ras, exon 15 of B-Raf and exons from 5 to 8 of PTEN. Nuclear PTEN expression was analyzed by immunohistochemistry and the expression in cancer cells was compared to that of normal cholangiocites. Results: Mutations of EGFR have been detected in 7 out of 49 samples (14.3%). One of them was a new stop-codon mutation. Five hotspot mutations of PI3K (codon 545, 546, 1048 and 1059) were found in 4 cases (8.2%); 3 cases (6.1%) had single mutations in K-Ras and 4 (8.2%) had the V599E mutation in B-Raf. In some samples, mutations of multiple trasducers were present simultaneously. PI3K mutations were significantly more frequent in EGFR mutated samples compared to wild type (28% vs. 4.7% respectively, p&lt;0.05). A single F271L mutation of PTEN was observed (2%). We did not find loss of nuclear PTEN in biliary tract carcinoma cells; rather, a stronger labelling intensity (score 2+ or 3+) was present in biliary tract carcinoma compared to normal cholangiocites (score 1+). Moreover, the median percentage of PTEN labeled nuclei in tumor cells was 31.8%, but in samples with activating EGFR mutation was 60%, suggesting that a compensatory change in the level of the phosphatase might counteract the EGFR activition. Conclusions: These results corroborate our previous finding of EGFR pathway activation in EGFR mutated biliary tract carcinoma and suggest that an accurate analysis of the entire series of EGFR transducers may be done before planning treatments with TKIs. No significant financial relationships to disclose.
Architectural Considerations of IP Anycast (2014)

This memo discusses architectural implications of IP anycast and
provides some historical analysis of anycast use by various IETF
protocols.
Bending rules for animal propulsion (2014)

Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there is no clear understanding of the role played by propulsor flexibility or, more fundamentally, how flexible propulsors should be designed for optimal performance. Here we demonstrate that during steady-state motion by a wide range of animals, from fruit flies to humpback whales, operating in either air or water, natural propulsors bend in similar ways within a highly predictable range of characteristic motions. By providing empirical design criteria derived from natural propulsors that have convergently arrived at a limited design space, these results provide a new framework from which to understand and design flexible propulsors.
Macrocycles 14. Polycondensations of Aspirin and Other Monomers of Salicylic Acid (2001)

Aspirin was polycondensed at various temperature-time combinations with or without the addition of a catalyst. Furthermore, several polycondensations of both the trimethylsilyl ester of aspirin, and o-trimethylsiloxybenzoyl chloride were conducted. Viscosity and GPC measurements indicated that from all three monomers only oligoesters having number average molecular weights (M̄n) ≤ 1 500 Da were obtained. FAB mass spectra of crude reaction products revealed that cyclic oligoesters (having DPs up to 7) were formed as the main reaction products under all circumstances. When ortho and meta trimethylsiloxybenzoyl chloride were copolycondensed with variation of the molar ratio, the molecular weights decreased with higher feed ratios of the salicylic acid derivative. Obviously, the salicylic monomer favored cyclization reactions at the expense of the chain growth. The predominant formation of cyclic oligoesters (with M̄ns up to 5 000 Da) was confirmed by MALDI-TOF mass spectra.
The effect of temperature, heating rate, and ZSM-5 catalyst on the product selectivity of the fast pyrolysis of spent coffee grounds (2015)

Pyrolysis (fast and slow, catalytic and thermal) is explored for the conversion of spent coffee grounds into higher value chemicals.
Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Structure analysis of an Fe-interlayer expanded zeolite. (2014)

Interlayer expansion using silylating agents to connect layer silicates to 3D framework structures has proofed to be a versatile synthesis route to new micro-porous frameworks (1). We show here that also Me-cations can be used as linker agents. An acidic Fe-chloride solution was used in a hydrothermal reaction to convert the hydrous layer silicate RUB-36 into an interlayer expanded zeolite, containing Fe at the linker site. Structure analysis of the new material Fe-COE-3, Si19.14Fe0.86O42, showed that the porous framework is stable after calcination and contains Fe on T-sites at the linker position which connects the two silicate layers. From chemical analysis it is confirmed that every other linker site is occupied by iron. The material crystallizes in space group Pm with a = 12.200(9) Å, b = 13.981(8) Å, c = 7.369(2) Å, ß = 106.9(1) 0 . Fig. 1 shows the results of the final Rietveld analysis (chi 2 = 8.8) and a projection of the framework structure along [001]. Because of the limited crystallinity of the material also the quality of the structure refinement is constricted. However, including complementary information from adsorption experiments, IR-, and UV-spectroscopy the structure model is confirmed without any doubt. Besides, the Rietveld analysis of the XRD data is the analytical tool to gain more detailed geometric information of the metallosilicate framework. The synthesis procedure is flexible and can be extended to other Me-cations as linker sites. We have prepared isostructural interlayer expanded metallosilicates of similar crystallinity with Ti, Sn, Zn, Eu, and Al as active centers. This method of inserting Me-cations as linkers in hydrous layer silicates shows for the first time that the active sites in the generated microporous silicate framework can be obtained in a controlled manner on well defined T-sites.
Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads (2014)

Socrates is released as open source and available from http://bioinf.wehi.edu.au/socrates CONTACT: papenfuss@wehi.edu.au Supplementary information: Supplementary data are available at Bioinformatics online.
B0−B0mixing andB→Xsγdecay in the third type 2HDM: Effects of NLO QCD contributions (2004)

In this paper, we calculate the next-to-leading order (NLO) new physics contributions to the mass splitting $\ensuremath{\Delta}{M}_{{B}_{d}}$ and the branching ratio $\mathcal{B}(\stackrel{\ensuremath{\rightarrow}}{B}{X}_{s}\ensuremath{\gamma})$ induced by the charged Higgs loop diagrams in the third type of two-Higgs-doublet models (model III) and draw the constraints on the free parameters of model III. For the model III under consideration, we find that (a) an upper limit $|{\ensuremath{\lambda}}_{\mathrm{tt}}|&lt;~1.7$ is obtained from the precision data of $\ensuremath{\Delta}{M}_{{B}_{d}}=0.502\ifmmode\pm\else\textpm\fi{}0.007{\mathrm{ps}}^{\ensuremath{-}1},$ while $|{\ensuremath{\lambda}}_{\mathrm{tt}}|\ensuremath{\approx}0.5$ is favored phenomenologicaly, (b) for $\stackrel{\ensuremath{\rightarrow}}{B}{X}_{s}\ensuremath{\gamma}$ decay, the NLO QCD contributions tend to cancel the LO new physics contributions, (c) a light charged Higgs boson with a mass around or even less than 200 GeV is still allowed at the NLO level by the measured branching ratio $\mathcal{B}(\stackrel{\ensuremath{\rightarrow}}{B}{X}_{s}\ensuremath{\gamma}),$ numerically, $188&lt;~{M}_{H}&lt;~215\mathrm{GeV}$ for $(|{\ensuremath{\lambda}}_{\mathrm{tt}}|,|{\ensuremath{\lambda}}_{\mathrm{bb}}|)=(0.5,18),$ (d) the NLO QCD contributions tend to cancel the LO contributions effectively, the lower limit on ${M}_{H}$ being consequently decreased by about 200 GeV, and (e) the allowed region of ${M}_{H}$ will be shifted toward the heavy mass end for a nonzero relative phase $\ensuremath{\theta}$ between the Yukawa couplings ${\ensuremath{\lambda}}_{\mathrm{tt}}$ and ${\ensuremath{\lambda}}_{\mathrm{bb}}.$ The numerical results for the conventional model II are also presented for the sake of comparison.
Depressive symptoms associated with gonadotropin-releasing hormone agonists (1998)

The gonadotropin-releasing hormone (GnRH) agonists are a relatively new class of drugs that are potentially effective in treating disorders that are aggravated either by estrogen or testosterone. GnRH agonists are effective in the treatment of endometriosis, as well as other disorders, such as advanced prostrate cancer, precocious puberty and uterine leiomyomata. While the GnRH agonists reduce the extent of the endometrial lesions and the occurrence of pelvic pain associated with endometriosis, these agents are associated with physical and psychiatric side effects. The adverse effects of these agents are consistent with the physiological effects of ovarian suppression, such as vasomotor instability, vaginal dryness, and headaches. Preliminary results of a prospective, double-blind placebo-controlled study and an open label trial indicates that depressive mood symptoms increase in women treated with GnRH agonist therapy for endometriosis. Additional evidence suggest that sertraline effectively manages depressive mood symptoms associated with GnRH agonist therapy. The reason for the decline in mood on GnRH agonists is postulated to be associated with the decline in estrogen levels. Effective treatment strategies for depressive mood symptoms in women on GnRH agonists therapy may offer insight into the mechanisms of action of estrogen on mood.
Dynamic Assignment of Flexible Service Resources (2009)

Resource flexibility is an important tool for firms to better match capacity with demand so as to increase revenues and improve service levels. However, in service contexts that require dynamically deciding whether to accept incoming jobs and what resource to assign to each accepted job, harnessing the benefits of flexibility requires using effective methods for making these operational decisions. Motivated by the resource deployment decisions facing a professional service firm in the workplace training industry, we address the dynamic job acceptance and resource assignment problem for systems with general resource flexibility structure, i.e., with multiple resource types that can each perform different overlapping subsets of job types. We first show that, for systems containing specialized resources for individual job types and a versatile resource type that can perform all job types, the exact policy uses a threshold rule. With more general flexibility structures, since the associated stochastic dynamic program is intractable, we develop and test three optimization‐based approximate policies. Our extensive computational tests show that one of the methods, which we call the Bottleneck Capacity Reservation policy, is remarkably effective in generating near‐optimal solutions over a wide range of problem scenarios. We also consider a model variant that requires dynamic job acceptance decisions but permits deferring resource assignment decisions until the end of the horizon. For this model, we discuss an adaptation of our approximate policy, establish the effectiveness of this policy, and assess the value of postponing assignment decisions.
OC-036 Neuronavigated Repetitive Cerebellar Stimulation Produces Long-Lasting Activation of Human Cortical Swallowing Projections (2013)

<h3>Introduction</h3> Animal studies, human brain imaging and more recently Transcranial Magnetic Stimulation (TMS) suggest a role for the cerebellum in human swallowing. Moreover, paired-pulse cerebellar-cortical TMS delivered in rapid succession (50–200 ms intervals) facilitates pharyngeal motor cortex excitability. We therefore hypothesised that high-frequency (5–20 Hz) repetitive TMS (rTMS) of the cerebellum could modulate pharyngeal motor cortex excitability producing long-lasting changes that may prove to be therapeutically useful for dysphagia after stroke. <h3>Methods</h3> In 17 healthy adults (6 female, age range 18–61 yrs), anatomical MR brain scans were acquired. Thereafter participants were intubated with an intraluminal catheter to record pharyngeal electromyography and underwent TMS cortical mapping with neuronavigation to co-localise pharyngeal motor representation bilaterally, hand motor cortex and the cerebellar site which evoked the largest pharyngeal motor response. Subjects were then randomised to receive one of 5 neuronavigated cerebellar rTMS interventions (Sham, 1 Hz, 5 Hz, 10 Hz and 20 Hz, at least 1 week apart) to the cerebellar site evoking the largest baseline pharyngeal responses to single-pulse cerebellar TMS. Bihemispheric pharyngeal cortical excitability (ipsilateral and contralateral cortex to cerebellum site) was measured at baseline and for up to one hour post cerebellar rTMS intervention. Abductor pollicis brevis (APB) recordings were used as control. Interventional data were compared to sham using repeated measures ANOVA. <h3>Results</h3> Cerebellar rTMS was tolerated well and delivered at an average intensity of 55% of stimulator output. Compared to Sham, 10Hz cerebellar rTMS increased pharyngeal cortical excitability (F (1.16) = 8.3, *<i>p</i> = 0.01), with maximal size and durational effects seen primarily in the contralateral pharyngeal cortex (+72%, **<i>p</i> = 0.02, <i>Figure 1</i>). By contrast, 1Hz (F (1.16) = 0.3, <i>p</i> = 0.60), 5Hz (F (1.16) = 0.5, <i>p</i> = 0.48), and 20Hz rTMS (F (1.16) = 1.3, <i>p</i> = 0.27) cerebellar conditioning did not significantly alter pharyngeal excitability compared to Sham. APB responses were not significantly different to sham after any intervention. <h3>Conclusion</h3> Our data show for the first time that high-frequency (10Hz) cerebellar stimulation can produce long-lasting increases in human pharyngeal motor cortex excitability, with larger and longer-lasting effects of the intervention primarily seen in the contralateral projection. Hence 10 Hz cerebellar rTMS may play a therapeutic role in the treatment of dysphagia after hemispheric stroke. <h3>Disclosure of Interest</h3> None Declared
Magnetoelectric Effect in Pb(Fe1/2Nb1/2)O3 (2007)

An anomaly in the magnetic susceptibility has been observed at and below the paraelectric – ferroelectric transition in polycrystalline Pb(Fe1/2Nb1/2)O3. The results are indicative of magnetoelectric coupling of the form P2M2. The non-linear relation between the induced magnetization and the applied magnetic field demonstrates the presence of large superparamagnetic clusters embedded in a paramagnetic medium over the whole ferroelectric phase, i.e. far above the antiferromagnetic transition temperature T N .
Live Well Deployment of Retrievable ESP Systems, Case Histories (2017)

Abstract Electrical submersible pumps (ESPs) are frequently the optimal artificial lift option to cost-effectively maximize reservoir recovery and production. However, the full potential of ESPs in offshore and remote locations has historically been limited by two key challenges: rig deployment and the inability to access the reservoir without pulling the production tubing. In order to reduce the burden operators face when utilizing conventional ESP systems, the company has developed a system that makes installation and retrieval of an ESP as simple as running a production logging tool; radically reducing the cost and downtime associated with ESP workovers by utilizing a lightweight slickline unit instead of a rig or workover unit to replace the ESP.
The case of the Robotics Academy @ Frederick University: 21st Century Skills Developed through a Non-formal Educational Setting (2020)

The Educational Robotics Curriculum developed by the Robotics Academy (Frederick University) provides a realistic, visually compelling, and motivating environment for integrating robotics as a cognitive-learning tool. The study evaluates the overall impact of the robotics educational curriculum delivered, in a non-formal educational setting, to develop the 21st century skills needed for today’s globalized, hi-tech environment. Specifically, employing a mixed method approach; the study explores the development of students’ critical thinking, creativity-innovation and collaboration skills, through hands-on, technology-based and unplugged activities. The analysis of the data collected through surveys, observations and focus groups, statistically and qualitatively revealed the positive impact and great potential of integrating robotics as a cognitive-learning tool to develop students’ 21st century skills.