gebhart/patrepeval huggingface dataset:
Oxygen-tension measurements - the first step towards prevention and early detection of anastomotic leakage (2007)

Many patients still die every year as a result of anastomotic leakage after surgery. The medical world needs an objective aid to detect leakage during surgery and during the critical recovery period. We propose a miniature measurement system to detect adequate tissue oxygenation pre-and postoperatively (continuously for 7 days) on the colon. The sensor chip should include an oxygen-saturation sensor, an oxygen-tension sensor, a carbon dioxide tension sensor and a temperature sensor. The work presented here focuses on the measurements done with the oxygen-tension and temperature sensors. In-vitro measurements were carried out to test the sensor system and initial in-vivo tests were performed on a rat kidney, during an ischemia-reperfusion experiment.
Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis (2012)

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that primarily involves the joints. Accurate and frequent assessment of RA disease activity is critical to optimal treatment planning. A novel algorithm has been developed to determine a multi-biomarker disease activity (MBDA) score based upon measurement of the concentrations of 12 serum biomarkers in multiplex format. Biomarker assays from several different platforms were used in feasibility studies to identify biomarkers of potential significance. These assays were adapted to a multiplex platform for training and validation of the algorithm. In this study, the analytical performance of the underlying biomarker assays and the MBDA score was evaluated. Quantification of 12 biomarkers was performed with multiplexed sandwich immunoassays in three panels. Biomarker-specific capture antibodies were bound to specific locations in each well; detection antibodies were labeled with electrochemiluminescent tags. Data were acquired with a Sector Imager 6000, and analyte concentrations were determined. Parallelism, dynamic range, cross-reactivity, and precision were established for each biomarker as well as for the MBDA score. Interference by serum proteins, heterophilic antibodies, and common RA therapies was also assessed. The individual biomarker assays had 3-4 orders of magnitude dynamic ranges, with good reproducibility across time, operators, and reagent lots; the MBDA score had a median coefficient of variation of <2% across the score range. Cross-reactivity as well as interference by serum rheumatoid factor (RF), human anti-mouse antibodies (HAMA), or common RA therapies, including disease-modifying antirheumatic drugs and biologics, was minimal. The same MBDA score was observed in different subjects despite having different biomarker profiles, supporting prior literature reports that multiple pathways contribute to RA.
In Vitro Biomechanical Testing of Two Injectable Materials for Vertebroplasty in Different Synthetic Bones (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Performance evaluation of LVM fault-localization protocol for all-optical networks (2008)

In this paper, we present a simulation platform to evaluate the performance of the limited-perimeter vector matching (LVM) fault localization protocol for all-optical networks. Through simulation results, we show that the LVM protocol can achieve excellent performance in terms of fault localization time while maintaining the maximum-level transparency of all-optical networks. This paper includes simulation results of only LVM on selected networks.
Neural correlates of sustained attention under sleep deprivation during a constant routine: circadian and homeostatic interaction (2014)

peer reviewed
PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion (1995)

Previously, the PhoP-repressed locus prgH was identified as important for signalling epithelial cells to endocytose Salmonella typhimurium. Characterization of prgH revealed that it is an operon of four genes encoding polypeptides of 392 (prgH), 80 (prgI), 101 (prgJ) and 252 amino acid residues (prgK). Synthesis of the 2.6 kb prgHIJK transcript was repressed in bacteria that activate PhoP/PhoQ, indicating that PhoP/PhoQ regulates prgHIJK by transcriptional repression. The prgI, prgJ and prgK predicted gene products were similar to Shigella flexneri and Yersinia enterocolitica proteins required for secretion of Ipa and Yop virulence factors. Analysis of the culture supernatants from wild-type S. typhimurium demonstrated that at least 25 polypeptides larger than 14 kDa could be detected. In contrast, prgH1::TnphoA, phoP-constitutive and hil-deletion mutants had significant defects in their supernatant protein profiles. The invasion and supernatant protein profile defects of the prgH1::TnphoA mutant were both complemented by a 5.1 kb plasmid that included prgHIJK. These results suggest that PhoP/PhoQ regulates extracellular transport of proteins by transcriptional repression of secretion determinants and that secreted proteins may be involved in signalling epithelial cells to endocytose bacteria.
ChemInform Abstract: CHEMISTRY OF THE HEXAHYDROPORPHYRINS. 2. 1,2,3,7,8,20‐HEXAHYDROPORPHYRIN, AN EASILY FORMED PORPHYRINOGEN ISOMERIC LIGAND SYSTEM (1980)

Abstract Octaethylporphyrinogen (I) setzt sich in unpolarem Medium unter Sauerstoffausschluß und tautomerisierungsfördernden Bedingungen mit Ni(II)‐acetat bei hoher Verdünnung zu den diastereomeren Ni(II)‐Komplexen (II) (Ausb. bis 90%) eines bisher nicht erkannten, hemicorrinoidpyrromethenischen Ligandsystems um.
Leu-M1 Immunoreactivity in Nonhematopoietic Neoplasms and Myeloproliferative Disorders: An Immunoperoxidase Study of Paraffin Sections (1986)

Leu-M1 is a differentiation antigen present on human myelomonocytic cells, which also has been identified in Reed-Sternberg cells and variants of Hodgkin's disease. This study further defines the tissue distribution of Leu-M1, with immunoreactivity observed for neoplastic cells in 14 of 28 formalin-fixed, paraffin-embedded nonhematopoietic neoplasms. With the use of monoclonal antibodies and an indirect immunoperoxidase technic, Leu-M1 was detected in adenocarcinomas of various sites (breast, lung, colon, thyroid, pancreas, and stomach), in squamous cell and transitional cell carcinomas, and in a small-cell anaplastic carcinoma. Evaluation of a wide variety of myeloproliferative disorders indicated that Leu-M1 effectively characterized mature and immature monocytic cells and myeloid cells at late stages of granulopoiesis, but it was not a reliable marker for early myeloid cells including blasts. Leu-M1 monoclonal antibodies are a useful diagnostic reagent, particularly in the assessment of lymphoproliferative disorders, but must be used with extreme caution and full awareness of its staining profile.
Optimization of Preparation Conditions of Activated Carbons Based on the Shells of &lt;i&gt;Ricinodendron heudoltii&lt;/i&gt; (2022)

The purpose of this work is to prepare better activated carbons from the shells of Ricinodendron Heudelotii by chemical activation with sulfuric acid (H2SO4) and sodium hydroxide (NaOH). The process was optimized by a full factorial design (2K) based on the analysis of the external specific surface area of sixteen (16) activated carbons prepared according to the parameters of the preparation. This active analysis reveals that under the preparation conditions, good carbons are obtained for a sodium hydroxide concentration equal to 1 M, an impregnation time of 24 h and carbonization at 500˚C for 1 h. The external specific surface of this carbon is 358 m2 • g-1. The characteristics of this prepared carbon are as follows: a pH at zero point charge (pHpzc) of 8.2, a predominantly amorphous structure, a basic character and a low ash content (4.2%). It also has surface functions; the lactonic and carbonyl groups (C=O) at 1600 cm-1 and the carboxylate groups (O-H or C-O) at 1340 cm-1.
Heterogeneous distributed shared memory (1992)

The design, implementation, and performance of heterogeneous distributed shared memory (HDSM) are studied. A prototype HDSM system that integrates very different types of hosts has been developed, and a number of applications of this system are reported. Experience shows that despite a number of difficulties in data conversion, HDSM is implementable with minimal loss in functional and performance transparency when compared to homogeneous DSM systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
InGaN multiquantum-well-structure laser diodes with GaN-AlGaN modulation-doped strained-layer superlattices (1998)

InGaN multiquantum-well-structure (MQW) laser diodes with Al/sub 0.14/Ga/sub 0.86/N-GaN modulation doped strained-layer superlattice (MD-SLS) cladding layers grown on an epitaxially laterally overgrown GaN substrate was demonstrated to have a lifetime of more than 2300 h under the condition of room-temperature continuous-wave operation. The self-pulsation was observed with a frequency of 3.5 GHz. The relative intensity noise less than -145 dB/Hz was obtained even at the 6% optical feedback using the high-frequency modulation of 600 MHz. The threshold carrier density of the InGaN MQW-structure laser diodes was estimated to be 3/spl times/10/sup 19//cm/sup 3/ using a carrier lifetime of 1.8 ns.
Data set for the proteomic inventory and quantitative analysis of chicken eggshell matrix proteins during the primary events of eggshell mineralization and the active growth phase of calcification (2015)

Chicken eggshell is a biomineral composed of 95% calcite calcium carbonate mineral and of 3.5% organic matrix proteins. The assembly of mineral and its structural organization is controlled by its organic matrix. In a recent study [1], we have used quantitative proteomic, bioinformatic and functional analyses to explore the distribution of 216 eggshell matrix proteins at four key stages of shell mineralization defined as: (1) widespread deposition of amorphous calcium carbonate (ACC), (2) ACC transformation into crystalline calcite aggregates, (3) formation of larger calcite crystal units and (4) rapid growth of calcite as columnar structure with preferential crystal orientation. The current article detailed the quantitative analysis performed at the four stages of shell mineralization to determine the proteins which are the most abundant. Additionally, we reported the enriched GO terms and described the presence of 35 antimicrobial proteins equally distributed at all stages to keep the egg free of bacteria and of 81 proteins, the function of which could not be ascribed.
Basic Principles of Inverse Problems for Optical Scientists (2017)

Abstract Modern optical imaging systems are complicated in nature and require solution of a mathematical inverse problem for image formation. In this article, we provide an overview of some basic concepts and mathematical descriptions of linear inverse problems. This includes a review of linear vector spaces, Hilbert spaces, and operators. The singular value decomposition (SVD) is reviewed as a tool to analyze imaging system models. Methods for finding solutions to the inverse problem for discrete systems are subsequently provided, as well as a specific example from differential phase contrast tomography.
Teledentistry from research to practice: a tale of nineteen countries (2023)

Despite the growth in teledentistry research during the COVID-19 pandemic, the use of teledentistry in daily clinical practice is still limited in most countries. Few countries have instituted teledentistry programs at national level. Laws, funding schemes and training are needed to support the incorporation of teledentistry into healthcare systems to institutionalize the practice of teledentistry. Mapping teledentistry practices in other countries and extending services to under-covered populations increases the benefit of teledentistry.
Working Safe: How to Help People Actively Care for Health and Safety, Second Edition (1996)

Orientation and Alignment Choosing the Right Approach Starting with Theory Paradigm Shifts for Total Safety Human Barriers to Safety The Complexity of People Sensation, Perception, and Perceived Risk Stress vs. Distress Behavior-Based Psychology Basic Principles Identifying Critical Behaviors Behavioral Safety Analysis Behavior-Based Intervention Intervening with Activators Intervening with Consequences Intervening as a Behavior-Change Agent Intervening with Supportive Conversation Actively Caring for Safety Understanding Actively Caring The Person-Based Approach to Actively Caring Increasing Actively Caring Behaviors Putting It All Together Promoting High-Performance Teamwork Evaluating for Continuous Improvement Obtaining and Maintaining Involvement Reviewing the Principles
PTH-143 Application of gold nanorods forin vivotheranostics of human oesophageal adenocarcinoma (2015)

<h3>Introduction</h3> Gold nanoparticles possess unique physiochemical properties due to their ability to target cancerous tissue and a strongly enhanced absorption of visible and near infra-red (NIR) light resulting in hyperthermia and photothermal therapy (PTT). Fluorescence emission from their functionalised surface provides diagnostic information regarding tumour location. Their biocompatibility <i><i>in vivo</i></i>is facilitated through surface polymer coating. We investigate these properties in human oesophageal adenocarcinoma by examining <i><i>in vitro</i></i>targeting of functionalised gold nanorods to human oesophageal adenocarcinoma cells (FLO-1) and evaluating the PTT of tumour xenografts <i><i>in vivo</i></i>. <h3>Method</h3> Multifunctional coated gold nanorods (GNRs) were fabricated using a seed-mediated method. Subsequent EDC/NHS chemistry functionalised the GNRs with a fluorophore (Cy 5.5) modified with anti-EGFR antibody. FLO-1 cells were fixed in paraformaldehyde in 0.1 mol/l PBS solution. Dilute functionalised GNRs were added and incubated overnight. Slides were then washed with PBS and stained with the nuclear dye DAPI prior to microscopic examination. Tumour xenografts were established in immunodeficient mice by subcutaneous inoculation of FLO-1 cells. When tumour size reached 5 mm, functionalized GNRs were administered either intratumourally (I. T.) or intravenously (I. V.). Fluorescence spectroscopy was performed followed by NIR irradiation of the tumour for 3 min using an 808 nm laser at 0.92 W. A thermal imaging camera measured the temperature changes that occurred. Inductively coupled plasma mass spectrometry (ICP-MS) measured gold concentrations in blood and organs remote to the tumour. <h3>Results</h3> Functionalised GNRs with a peak optical absorption at 808 nm were used. Fluorescence imaging of immunohistochemically stained FLO-1 cells demonstrated active <i><i>in vitro</i></i>targeting of GNRs. NIR irradiation of tumours established 12°C and 18°C temperature increases in mice receiving I. V. and I. T. GNRs respectively. Histological examination of tumour sites showed fully preserved tissue layers with no signs of proliferating tumour. ICP-MS revealed no evidence of toxic accumulation of gold in blood, kidneys, liver or spleen after 30 days. <h3>Conclusion</h3> Fluorescence detection of functionalised GNRs that localise to cancerous tissue may enhance oesophageal cancer diagnosis. When coupled with NIR irradiation, this is an effective method of inducing irreversible tumour photodestruction, with minimal collateral damage expected in healthy tissues. The strong absorption of GNRs of relatively low laser energies renders the therapy method minimally invasive. <h3>Disclosure of interest</h3> None Declared.
Generation of a Recombinant Apolipoprotein E Variant with Improved Biological Functions (2004)

To identify the residues in the carboxyl-terminal region 260-299 of human apolipoprotein E (apoE) that contribute to hypertriglyceridemia, two sets of conserved, hydrophobic amino acids between residues 261 and 283 were mutated to alanines, and recombinant adenoviruses expressing these apoE mutants were generated. Adenovirus-mediated gene transfer of apoE4-mut1 (apoE4 (L261A, W264A, F265A, L268A, V269A)) in apoE-deficient mice (apoE(-/-)) corrected plasma cholesterol levels and did not cause hypertriglyceridemia. In contrast, gene transfer of apoE4-mut2 (apoE4 (W276A, L279A, V280A, V283A)) did not correct hypercholesterolemia and induced mild hypertriglyceridemia. ApoE-induced hyperlipidemia was corrected by co-infection with a recombinant adenovirus expressing human lipoprotein lipase. Both apoE4 mutants caused only a small increase in hepatic very low density lipoprotein-triglyceride secretion. Density gradient ultracentrifugation analysis of plasma and electron microscopy showed that wild-type apoE4 and apoE4-mut2 displaced apoA-I from the high density lipoprotein (HDL) region and promoted the formation of discoidal HDL, whereas the apoE4-mut1 did not displace apoA-I from HDL and promoted the formation of spherical HDL. The findings indicate that residues Leu-261, Trp-264, Phe-265, Leu-268, and Val-269 of apoE are responsible for hypertriglyceridemia and also interfere with the formation of HDL. Substitutions of these residues by alanine provide a recombinant apoE form with improved biological functions.
Efficient Tm:Fiber pumped solid-state Ho:YLF 2-µm laser for remote sensing applications (2013)

An efficient 19 W, TEM00 mode, Ho:YLF laser pumped by continuous wave Tm:fiber laser has been demonstrated at the room temperature. The slope efficiency and optical-to-optical efficiency are 65% and 55%, respectively.
Solvent-enhanced dye diffusion in polymer thin films for color tuning of organic light-emitting diodes (2001)

A method of solvent-enhanced dye diffusion in polymer films for organic light-emitting diode (OLED) application is introduced. After an initial dye transfer from a dye source substrate into the top of the device polymer film, the device substrate is then exposed to solvent vapor. Due to solvent absorption by the polymer film, the glass transition temperature of the polymer is significantly decreased which leads to enhanced diffusion of the dye in the polymer film. Secondary ion mass spectroscopy and depth dependent photoluminescence show that the temperature for dye diffusion can be decreased by at least 100 °C, to room temperature. OLEDs with 0.6% external quantum efficiency have been demonstrated with this method using the polymer poly(9-vinylcarbazole) combined with electron transport molecules and the dyes coumarin 47 and coumarin 6.
Implementation of FFT on Massively Parallel GPU for DVB-T Receiver (2013)

최근 GPU의 뛰어난 병렬 연산 처리 능력을 이용하여 신호 처리나 통신 시스템을 소프트웨어로 구현하기 위한 다양한 연구가 진행되고 있다. 본 논문에서는 DVB-T에서 사용되는 2K/8K FFT를 GPU를 이용하여 처리함으로써 소프트웨어 모의실험에 소요되는 시간을 줄였다. 우리는 먼저 DTV 전송 표준 방식의 일종인 DVB-T 시스템을 CPU로 구현할 때 소요되는 처리 시간을 모의실험을 통해서 추정한다. 그리고 DVB-T의 핵심 연산 처리기의 일종인 FFT 처리를 NVIDIA사의 대용량 GPU 프로세서를 이용하여 소프트웨어로 구현한다. 본 논문은 CPU와 GPU 간의 데이터 전송에 소요되는 오버헤드를 줄이기 위해 스트림 처리 기법, 외부 전역 메모리 전송 시간을 단축하기 위한 결합 전송 기법 (coalescing), 공유 메모리 활용을 높이기 위한 변수 설계 기법 등을 통해서 연산시간을 대폭 단축하였다. 그 결과 제안된 방식은 DVB-T의 2K/8K FFT 모드의 경우 CPU 기반의 FFT 처리 방식 대비 약 20~30배, NVIDIA사에서 제공하는 FFT 라이브러리 (CUFFT version 2.1) 대비 약 1.8배 그리고 기존에 발표된 타 방식 대비 약 1.5~10배 정도 빠른 처리 능력을 보인다. Recently various research have been conducted relating to the implementation of signal processing or communication system by software using the massively parallel processing capability of the GPU. In this work, we focus on reducing software simulation time of 2K/8K FFT in DVB-T by using GPU. we estimate the processing time of the DVB-T system, which is one of the standards for DTV transmission, by CPU. Then we implement the FFT processing by the software using the NVIDIA's massively parallel GPU processor. In this paper we apply stream process method to reduce the overhead for data transfer between CPU and GPU, coalescing method to reduce the global memory access time and data structure design method to maximize the shared memory usage. The results show that our proposed method is approximately 20~30 times as fast as the CPU based FFT processor, and approximately 1.8 times as fast as the CUFFT library (version 2.1) which is provided by the NVIDIA when applied to the DVB-T 2K/8K mode FFT.
Modifications of Streptomyces signal peptides and their effects on protein production and secretion (1998)

As for other organisms, proteins to be secreted in Streptomyces are produced as preproteins consisting of the mature protein preceded by a N-terminal signal peptide which is cleaved off during membrane translocation. Although primary sequences are seldom conserved among signal peptides, they all have a typical tripartite structure: a basic amino-terminus, a central apolar core and a carboxy-terminal region containing the signal peptidase recognition site. In vitro mutagenesis studies have been carried out on various signal peptides to analyse the structure–function relationship of each of the three regions of Streptomyces signal peptides. In the current paper the present knowledge of Streptomyces leader sequences and the impact of introduced mutations on transcription, translation and secretion of homologous and heterologous proteins is reviewed.
Lactic acid bacterial starter cultures in the preservation of spent grains used as animal feed (1995)

Abstract Studies to improve the stability of spent grains from two different mash separation processes (lauter tun, mash filter) were carried out with selected starter cultures. High quality of spent grains was achieved after four weeks of storage at +6°C. The growth of clostridia, enterobacteria and fungi was inhibited at 2O°C when the starters were added to cooled spent grains from the mash filter. The antimicrobial activities of starter cultures were weaker in spent grains from the lauter tun and in hot spent grains directly from the silo. The use of starter cultures offers an opportunity for the safe ensilage of spent grains.
Connective tissue markers of rheumatoid arthritis (1998)

Rheumatoid arthritis (RA) is a common systemic autoimmune disorder of unknown aetiology. The most common outcome of RA is a progressive development of joint destruction and deformity. Early introduction of disease-modifying antirheumatic drugs seems important for prevention of the long term injuries of articular cartilage and bone. Early diagnosis and selection of patients with rapidly progressive disease therefore is of clinical significance. Routine laboratory tests are valuable in monitoring for renal, hepatic and haematological side effects of medical treatment. Determination of rheumatoid factor contributes to the classification of arthritis as RA, and acute phase reactants are useful for quantifying and comparing the level of inflammatory activity in the course of a given patient. There is, however, a lack of sensitive and specific biochemical markers for RA, and frontline biochemical research is devoted to characterizing molecules which are of diagnostic and prognostic value, as well as molecules which are indicators of the degree of joint cartilage and bone destruction. The present survey summarizes current knowledge concerning possible tissue-specific marker molecules of RA.