gebhart/patrepeval huggingface dataset:
Vibrational dynamics (IR, Raman, NRVS) and a DFT study of a new antitumor tetranuclearstannoxane cluster, Sn(iv)-oxo-{di-o-vanillin} dimethyl dichloride (2016)

Complex <bold>1</bold> showing NRVS, Raman spectra and antitumor activity.
Protective Effects of Spermidine Against Cirrhotic Cardiomyopathy in Bile Duct-Ligated Rats (2020)

Cirrhotic cardiomyopathy is a critical factor that causes morbidity and mortality in crucial conditions such as liver transplantation. In animal model, the common pathophysiologic mechanisms of cirrhotic cardiomyopathy are similar to those associated with bile duct ligation (BDL). Overproduction of inflammatory and oxidant markers plays a crucial role in cirrhotic cardiomyopathy. Spermidine, a multifunctional polyamine, is known for its antioxidant and anti-inflammatory effects. In this study, we investigated the effects of spermidine on development of cirrhotic cardiomyopathy in BDL rats. Rats were randomly housed in 6 groups. Except the normal and sham groups, BDL was performed for all the control and spermidine groups. Seven days after operation, 3 different doses of spermidine (5, 10 and 50 mg/kg) were administrated until day 28, in spermidine groups. At the end of the fourth week, the electrocardiography (ECG) and papillary muscle isolation were performed. The serum level of tumor necrosis factor-a (TNF-α), interleukin-1β (IL-1β), and IL-10 and cardiac level of superoxide dismutase, glutathione (GSH). and malondialdehyde (MDA) were assessed. Furthermore, the nuclear factor-κB (NF-κB) expression was assessed by western blot. Cardiac histopathological changes were monitored. The serum levels of magnesium (Mg) and potassium (K) were investigated. Control group, exhibited exaggerated signs of cirrhotic cardiomyopathy in comparison with the sham group. Co-administration of spermidine at the dose of 10 mg/kg in BDL rats significantly improved the cardiac condition, reduced the inflammatory mediators, and increased antioxidant enzymes. In addition, the histopathologic findings were in accordance with the other results of the study. Besides, there was no significant alteration in serum levels of Mg and K. This study demonstrates that spermidine at the dose of 10 mg/kg significantly improved the cirrhotic cardiomyopathy in BDL model in rats.
Grasping and Manipulation in Humanoid Robotics (2000)

Humanoid robotics is attracting the interest of many research groups world-wide. In particular, developing humanoids requires the implementation of manipulation capabilities, which is still a most complex problem in robotics. This paper presents an overview of current activities in the development of humanoid robots, with special focus on manipulation. Then we discuss our current approach to the design and development of anthropomorphic sensorized hand and of anthropomorphic control and sensory-motor coordination schemes. Current achievements in the development of a robotic human hand prosthesis are described, together with preliminary experimental results, as well as in the implementation of biologically-inspired schemes for control and sensory-motor co-ordination in manipulation, derived from models of well-identified human brain areas.
Dimensionless Characteristics of Centrifugal Pump (2005)

Centrifugal pump characteristics (i.e. specific energy gH, power P, and efficiency η curves plotted vs. flow capacity Q) at different pump operating speeds are important to the successful operation of pumps in various areas of chemical technology. In the present paper the pump characteristics are treated in a dimensionless form. The main advantage of this approach is the fact that only one characteristic curve is used for all possible operating speeds of the tested pump in the frame of suitable dimensionless numbers. Also, the obtained relation between dimensionless numbers allows to estimate the main pump characteristics in the case when the properties (ρ and μ) of the liquid were varied.
Value delivery through IT-based healthcare architectures (2010)

The competiveness of the healthcare industry increasingly hinges on the strategic competence to create value for patients, insurance companies, employees and investors, alike under conditions of hyper-turbulence (Braun von Reinersdorff, 2007). While in the past public healthcare institutions took advantage of strong national regulation regimes, free-wheeling market forces in European service sectors will take on added significance and endanger entrenched business models (Olmsted Teisberg, 2007). To make things worse, the demographic changes towards geriatric societies and ensuing chronic diseases may cause a financial collapse of national healthcare institutions, which are anything, but adaptive and robust (Porter and Teisberg, 2004). Given scarce healthcare resources facing an inflating demand for medical treatment, healthcare companies should harness the value potential of IT-induced process innovations. Instead of launching medical ‘rocket science’ output innovations, sometimes even missing evidence criteria due to their early-stage status, healthcare companies will be forced to adopt core elements of the industrial production paradigm (Braun von Reinersdorff, 2007).
Peptide Nucleic Acids (PNA)-DNA Chimeras Targeting Transcription Factors as a Tool to Modify Gene Expression (2004)

Peptide nucleic acids (PNAs)-DNA chimeras have been recently described as DNA mimics constituted of a part of PNA and of a part of DNA. We have demonstrated that double stranded molecules based on PNA-DNA chimeras bind to transcription factors in a sequence-dependent manner. Accordingly, these molecules can be used for transcription factor decoy (TFD) pharmacotherapy. Effects of double stranded PNA-DNA chimeras targeting NF-kappaB and Sp1 were determined on in vitro cultured human cells and were found to be comparable to those observed using double-stranded DNA decoys. The TFD molecules based on PNA-DNA chimeras can be further engineered by addition of short peptides facilitating cell penetration and nuclear localization. Therefore, these engineered molecules could be of great interest for in vivo experiments for non-viral gene therapy of a variety of diseases, including neoplastic and viral diseases, for which the TFD approach has been already demonstrated as a very useful strategy.
Learning from the Moth: A Comparative Study of Robot-Based Odor Source Localization Strategies (2009)

The odor search strategies of the moth have been researched since many decades. Many behavioral studies have described the behavior under well controlled conditions, making predictions on what the underlying mechanisms might be. However, it is almost impossible to asses these mechanisms directly since sensory and behavioral data on a freely behaving moth are very hard to obtain. Therefore, we propose a comparative study were the behavior of a robot is analyzed when controlled by a number of odor source localization models. Our results show that a system making use of stereo odor information outperforms some well‐established chemical search models.
A statistical admission control algorithm for multimedia servers (1994)

A large-scale multimedia server, in practice, has to service a large number of clients simultaneously. Given the real-time requirements of each client and the fixed data transfer bandwidth of disks, a multimedia server must employ admission control algorithms to decide whether a new client can be admitted for service without violating the requirements of the clients already being serviced. In this paper, we present an admission control algorithm for multimedia servers which: (1) exploits the variation in access times of media blocks from disk as well as the variation in client load induced by variable rate compression schemes, and (2) provides statistical service guarantees to each client. The effectiveness of the algorithm is demonstrated through trace-driven simulations.
Mitigation and Predictive Assessment of SET Immunity of Digital Logic Circuits for Space Missions (2020)

Due to the intrinsic masking effects of combinational circuits in digital designs, Single-Event Transient (SET) effects were considered irrelevant compared to the data rupture caused by Single-Event Upset (SEU) effects. However, the importance of considering SET in Very-Large-System-Integration (VLSI) circuits increases given the reduction of the transistor dimensions and the logic data path depth in advanced technology nodes. Accordingly, the threat of SET in electronics systems for space applications must be carefully addressed along with the SEU characterization. In this work, a systematic prediction methodology to assess and improve the SET immunity of digital circuits is presented. Further, the applicability to full-custom and cell-based design methodologies are discussed, and an analysis based on signal probability and pin assignment is proposed to achieve a more application-efficient SET-aware optimization of synthesized circuits. For instance, a SET-aware pin assignment can provide a reduction of 37% and 16% on the SET rate of a NOR gate for a Geostationary Orbit (GEO) and the International Space Station (ISS) orbit, respectively.
Supplemental Table 4 from Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA (2023)

&lt;p&gt;Summary of driver and resistance mutations in EGFR and ALK detected in ctDNA, tDNA, and both ctDNA and tDNA&lt;/p&gt;
Spot-Scan Imaging in Transmission Electron Microscopy (1991)

The determination of the structure of proteins and other organic materials by transmission electron microscopy is a rapidly developing field. Obtaining high-resolution images of these radiation-sensitive specimens has, until recently, been problematic. The development of spot-scan imaging, in which the electron beam is focused to a spot with a diameter of about 1000 angstroms and moved over the specimen to record the image, has overcome some of the most severe problems, which result from beam-induced motion of the specimen and its image. Elimination of this motion greatly enhances the contrast of high-resolution features of the image and promises a significant increase in the speed with which future structural work can be accomplished.
Correctors of mutant CFTR enhance subcortical cAMP–PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization (2016)

The most common mutation of the cystic fibrosis transmembrane regulator (CFTR) gene, F508del, produces a misfolded protein resulting in its defective trafficking to the cell surface and an impaired chloride secretion. Pharmacological treatments partially rescue F508del CFTR activity either directly by interacting with the mutant protein and/or indirectly by altering the cellular protein homeostasis. Here, we show that the phosphorylation of ezrin together with its binding to phosphatidylinositol-4,5-bisphosphate (PIP2) tethers the F508del CFTR to the actin cytoskeleton, stabilizing it on the apical membrane and rescuing the sub-membrane compartmentalization of cAMP and activated PKA. Both the small molecules trimethylangelicin (TMA) and VX-809, which act as 'correctors' for F508del CFTR by rescuing F508del-CFTR-dependent chloride secretion, also restore the apical expression of phosphorylated ezrin and actin organization and increase cAMP and activated PKA submembrane compartmentalization in both primary and secondary cystic fibrosis airway cells. Latrunculin B treatment or expression of the inactive ezrin mutant T567A reverse the TMA and VX-809-induced effects highlighting the role of corrector-dependent ezrin activation and actin re-organization in creating the conditions to generate a sub-cortical cAMP pool of adequate amplitude to activate the F508del-CFTR-dependent chloride secretion.
Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self (2006)

Although the optimal donor for allogeneic hematopoietic stem cell transplantation (HSCT) is a human leukocyte antigen-matched sibling, 75% of patients do not have a match, and alternatives are matched unrelated volunteers, unrelated umbilical cord blood units, and full-haplotype-mismatched family members. To cure leukemia, allogeneic HSCT relies on donor T cells in the allograft, which promote engraftment, eradicate malignant cells, and reconstitute immunity. Here, we focus on the open issues of rejection, graft-versus-host disease (GVHD), and infections and the benefits of natural killer (NK) cell alloreactivity and its underlying mechanisms. Donor-versus-recipient NK cell alloreactivity derives from a mismatch between inhibitory receptors for self-major histocompatibility complex (MHC) class I molecules on donor NK clones and the MHC class I ligands on recipient cells. These NK clones sense the missing expression of the self-MHC class I allele on the allogeneic targets and mediate alloreactions. HSCT from 'NK alloreactive' donors controls acute myeloid relapse without causing GVHD. We review the translation of NK cell recognition of missing self into the clinical practice of allogeneic hematopoietic transplantation and discuss how it has opened innovative perspectives in the cure of leukemia.
Halomethyl-metal compounds. XXIII. Preparation of bis(triorganotin)dihalomethanes by dihalocarbene insertion into the Sn-Sn bond of hexaorganoditin compounds (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalomethyl-metal compounds. XXIII. Preparation of bis(triorganotin)dihalomethanes by dihalocarbene insertion into the Sn-Sn bond of hexaorganoditin compoundsDietmar Seyferth, Frank M. Armbrecht Jr., and Bernd SchneiderCite this: J. Am. Chem. Soc. 1969, 91, 8, 1954–1957Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://pubs.acs.org/doi/10.1021/ja01036a015https://doi.org/10.1021/ja01036a015research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Impact of hospital volume on mortality and cost in sepsis based on a Japanese nationwide medical claims database study—the Japan Sepsis Alliance study group (2022)

Abstract Background: The impact of hospital volume on the mortality rate and medical costs in sepsis has not been fully elucidated. We hypothesized that high-volume hospitals have low mortality rates and high medical costs in sepsis cases. Methods: This retrospective study used the administrative data from 2010 to 2017. The hospital volume categorization into quartiles was performed according to the annual number of sepsis cases. The primary outcome was in-hospital mortality. The secondary outcomes were medical costs and length of hospital stay. A mixed-effects logistic model with a two-level hierarchical structure was used to adjust for baseline imbalances. Fractional polynomials and restricted cubic splines were investigated to determine the significance of the association between the hospital volume and clinical outcomes. Subgroup and sensitivity analyses were performed for the primary outcome. Results: Among 1,781,014 sepsis patients from 1,622 hospitals, the crude in-hospital mortality rate was 22.1% and 17.0% in the lowest and highest quartile of sepsis volume, respectively (p &lt; 0.0001). After adjustment for confounding factors, the in-hospital mortality in the highest quartile was significantly lower than that of the lowest quartile (odds ratio, 0.789; 95% confidence interval, 0.774–0.804; p &lt; 0.0001). Investigations with fractional polynomials and restricted cubic splines revealed that the hospital volume was significantly associated with in-hospital mortality (p &lt; 0.0001). The highest quartile had higher daily medical costs per person and shorter length of hospital stay than those of the lowest quartile. Subgroup analyses showed that the high-volume hospitals with patients subjected to intensive care unit admission, mechanical ventilation, vasopressor therapy, and renal replacement therapy had a significantly low in-hospital mortality (p &lt; 0.0001). The sensitivity analysis, excluding patients who were transferred to other hospitals, demonstrated a result consistent with that of the primary test. Conclusions: This nationwide sepsis study using the medical claims database suggested that a higher hospital volume leads to lower in-hospital mortality and higher daily medical costs per person. Further research is needed to investigate the mechanism of the case volume–outcome relationship in sepsis cases.
Molecular Beacon Imaging to Visualize Ki67 mRNA for Cell Proliferation Ability (2020)

The objective of this study is to visualize the ability of cell proliferation based on molecular beacons (MB). Two types of MB to detect messenger RNA (mRNA) were used. One is a Ki67 MB of a target for cell proliferation ability. The other one is a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) MB as a control of stable fluorescence in cells. To enhance the MB internalization into cells, the MB were incorporated into cationized gelatin nanospheres (cGNS). There was no difference in the physicochemical properties and the cell internalization between the cGNS<sub>Ki67 MB</sub> and cGNS<sub>GAP MB</sub>. When basic fibroblast growth factor (bFGF) was added to KUM6 cells of a mouse bone marrow-derived mesenchymal stem cell line, the expression of Ki67 and the cell proliferation increased with the bFGF concentration. After the incubation for the cell internalization of cGNS incorporating MB (cGNS<sub>MB</sub>), the cells were further incubated for 24 h with or without different concentrations of bFGF. The fluorescence of cGNS<sub>Ki67 MB</sub> significantly increased with the increase of bFGF concentration, whereas that of cGNS<sub>GAP MB</sub> was constant, irrespective of the bFGF concentration. A time-lapse imaging assay revealed a fast enhancement of cGNS<sub>Ki67 MB</sub> fluorescence after the bFGF addition compared with no bFGF addition. On the other hand, for cGNS<sub>GAP MB</sub>, a constant fluorescence was observed even at any time point after the bFGF addition. It is concluded that the cGNS<sub>MB</sub> system is promising for the chronological visualization of proliferation ability in living cells.
Heat inactivation of human immunodeficiency virus in solutions of antithrombin III (1989)

Human immunodeficiency virus (HIV), isolated from cultures of infected peripheral blood lymphocytes, was added to solutions of highly purified antithrombin III (AT-III), which was stabilized with 1 M citrate and 17 percent sucrose. The efficiency of heat inactivation of HIV in AT-III at 60 degrees C was compared with that of HIV in culture medium and followed for periods from 0 to at least 10 hours. The virus added, titer 10(5) by ID50, was inactivated as rapidly (less than 30 minutes) and efficiently (completely) in the stabilized AT-III as in the culture medium. Virus was determined both by direct measurement of the HIV-related reverse transcriptase activity and by quantitation of virus infectivity by ID50 assay.
Mechanism for a Directional, Processive, and Reversible DNA Motor (2009)

Two left feet? Directionality is established in a processive DNA motor by coordinating the reactivities of two identical feet (see picture). Energy is provided by hydrolysis of a single-stranded DNA fuel. The directional bias of the motor can be controlled through the choice of fuel.
HMG-COA REDUCTASE INHIBITORS SIGNIFICANTLY IMPROVE SURVIVAL IN CLINICAL LUNG TRANSPLANTATION, A RETROSPECTIVE ANALYSIS OF MORE THAN 500 PATIENTS (2004)

P647 Aims: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are known as effective lipid-lowering agents. Recently, increased survival times were demonstrated after transplantation (heart, kidney, liver) in patients, receiving statins and there is data suggesting a lipid lowering independent effect, as statins act as direct inhibitors of induction of MHC class-II expression and thus as indirect repressors of T-cell activation. We evaluated the effects of statins after lung transplantation through a retrospective analysis of 500 lung-allograft recipients, of whom77 received statins for excessive serum lipid levels. Methods: We performed a retrospective analysis of 502 recipients after lung transplantation (1988-2003). In order to allow for comparability of the patients receiving statins with those who did not, patients who died before the post operative day of first statin administration were excluded (n=77). 3 Patients had to be excluded from the statin group, due to missing clinical data. Statistical analysis included survival, as well as lung function analyses. BOS was defined by loss of FEV1, with BOS 0 = 80-100% of best FEV1, BOS 1 = 65-80% of best FEV1, BOS 2 = 50-65% of best FEV1 and BOS 3 = <50% of best FEV1. Results: Out of 502 patients undergoing lung transplantation between 1988 and 2003, 77 received pravastatin, 2 received lovastatin and 6 simvastatin for treatment of elevated serum lipid levels. Comparison of the two cohorts showed a significant increase in survival in the statin group (2435.31±1260.51 day vs.1595.10±1338.50 day, P<0.0001). Also, lung function was preserved at a significantly higher level in the group receiving statins (FVCBEST: 3809±1094.63ml vs 3509±1170.36ml, P<0.05; FEV1BEST: 2975±967.99ml vs 2695±1014.18ml, P<0.05). Conclusions: Pravastatin significantly improves long-term survival after lung transplantation in a retrospective analysis. Thus, we have added pravastatin to our standard immunosuppressive regimen. As the underlying mechanism is still unclear, we have initiated animal experiments to further analyze this question.
Controlling the speed of light pulses (2002)

Recent experiments have demonstrated that light pulses can be made to propagate `superluminally' or, at the opposite extreme, to come to a complete stop. Some of the basic physics underlying these studies and their antecedents are reviewed.