gebhart/patrepeval huggingface dataset:
Development of an automated high-temperature valveless injection system for online gas chromatography (2014)

Abstract. A reliable method of sample introduction is presented for online gas chromatography with a special application to in situ field portable atmospheric sampling instruments. A traditional multi-port valve is replaced with a valveless sample introduction interface that offers the advantage of long-term reliability and stable sample transfer efficiency. An engineering design model is presented and tested that allows customizing this pressure-switching-based device for other applications. Flow model accuracy is within measurement accuracy (1%) when parameters are tuned for an ambient-pressure detector and 15% accurate when applied to a vacuum-based detector. Laboratory comparisons made between the two methods of sample introduction using a thermal desorption aerosol gas chromatograph (TAG) show that the new interface has approximately 3 times greater reproducibility maintained over the equivalent of a week of continuous sampling. Field performance results for two versions of the valveless interface used in the in situ instrument demonstrate typically less than 2% week−1 response trending and a zero failure rate during field deployments ranging up to 4 weeks of continuous sampling. Extension of the valveless interface to dual collection cells is presented with less than 3% cell-to-cell carryover.
3D-carrier profiling in FinFETs using scanning spreading resistance microscopy (2011)

In this work, we demonstrate for the first time 3D-carrier profiling in FinFETs with nm-spatial resolution using SSRM. The results provide information on gate underlap, dopant conformality, source/drain doping profiles. The 3D-carrier profiles as extracted for two different device approaches (extensions vs. extension-less) are conclusive in demonstrating the differences in device performance and are consistent with first order 3D-simulations.
Supplementary Legends - Figures 1-3, Tables 1-2 from Dominant-Negative Activator Protein 1 (TAM67) Targets Cyclooxygenase-2 and Osteopontin under Conditions in which It Specifically Inhibits Tumorigenesis (2023)

Supplementary Legends - Figures 1-3, Tables 1-2 from Dominant-Negative Activator Protein 1 (TAM67) Targets Cyclooxygenase-2 and Osteopontin under Conditions in which It Specifically Inhibits Tumorigenesis
SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing (2008)

The insulin receptor (IR) exists as two isoforms, IR-A and IR-B, which result from alternative splicing of exon 11 in the primary transcript. This alternative splicing is cell specific, and the relative proportions of exon 11 isoforms also vary during development, aging, and different disease states. We have previously demonstrated that both intron 10 and exon 11 contain regulatory sequences that affect IR splicing both positively and negatively. In this study, we sought to define the precise sequence elements within exon 11 that control exon recognition and cellular factors that recognize these elements. Using minigenes carrying linker-scanning mutations within exon 11, we detected both exonic splicing enhancer and exonic splicing silencer elements. We identified binding of SRp20 and SF2/ASF to the exonic enhancers and CUG-BP1 to the exonic silencer by RNA affinity chromatography. Overexpression and knockdown studies with hepatoma and embryonic kidney cells demonstrated that SRp20 and SF2/ASF increase exon inclusion but that CUG-BP1 causes exon skipping. We found that CUG-BP1 also binds to an additional intronic splicing silencer, located at the 3' end of intron 10, to promote exon 11 skipping. Thus, we propose that SRp20, SF2/ASF, and CUG-BP1 act antagonistically to regulate IR alternative splicing in vivo and that the relative ratios of SRp20 and SF2/ASF to CUG-BP1 in different cells determine the degree of exon inclusion.
Selenium and selenoproteins in health and disease (Forum Editorial) (2010)

The beneficial role of the trace element selenium (Se) in human health has been known for several decades and is attributed both to low-molecular-weight Se compounds and to its presence within 25 selenoproteins in the form of the amino acid selenocysteine (Sec). Incorporation of Sec into selenoproteins involves decoding of the UGA codon. This process requires multiple features, such as the Sec-insertion sequence (SECIS) element and protein factors, including a specific elongation factor EFSec and the SECIS-binding protein 2, SBP2. Although many selenoproteins remain functionally uncharacterized, some of their known functions include redox regulation of intracellular signaling, redox homeostasis, and thyroid hormone metabolism. Pathologically, reduced expression of selenoproteins has been directly linked with the congenital muscle disease referred to as selenoprotein N (SEPN)-related myopathy and with thyroid-hormone metabolism defects (deficiency of deiodinases due to genetic defects in SBP2). From a broader, less well defined aspect, selenium compounds and selenoproteins have been linked to prevention of some forms of cancer, Alzheimer's disease, cardiovascular disease, and life span. This forum summarizes recent advances in our understanding of important roles of selenium, selenoproteins, and factors involved in selenoprotein synthesis in health and disease and discusses potential targets for therapy.
The hypothalamic satiety peptide CART is expressed in anorectic and non‐anorectic pancreatic islet tumors and in the normal islet of Langerhans (1999)

The hypothalamic satiety peptide CART (cocaine and amphetamine regulated transcript) is expressed at high levels in anorectic rat glucagonomas but not in hypoglycemic insulinomas. However, a non-anorectic metastasis derived from the glucagonoma retained high CART expression levels and produced circulating CART levels comparable to that of the anorectic tumors. Moreover, distinct glucagonoma lines derived by stable HES-1 transfection of the insulinoma caused severe anorexia but retained low circulating levels of CART comparable to that of insulinoma bearing or control rats. Islet tumor associated anorexia and circulating CART levels are thus not correlated, and in line with this peripheral administration of CART (5-50 mg/kg) produced no effect on feeding behavior. In the rat two alternatively spliced forms of CART mRNA exist and quantitative PCR revealed expression of both forms in the hypothalamus, in the different islet tumors, and in the islets of Langerhans. Immunocytochemistry as well as in situ hybridization localized CART expression to the somatostatin producing islet D cell. A potential endocrine/paracrine role of islet CART remains to be clarified.
Dissemination of Flow Specification Rules (2009)

This document defines a new Border Gateway Protocol Network Layer Reachability Information (BGP NLRI) encoding format that can be used to distribute traffic flow specifications.This allows the routing system to propagate information regarding more specific components of the traffic aggregate defined by an IP destination prefix.Additionally, it defines two applications of that encoding format: one that can be used to automate inter-domain coordination of traffic filtering, such as what is required in order to mitigate (distributed) denial-of-service attacks, and a second application to provide traffic filtering in the context of a BGP/MPLS VPN service.The information is carried via the BGP, thereby reusing protocol algorithms, operational experience, and administrative processes such as inter-provider peering agreements.
[Adrenal medullary graft induces recovery of the host nigrostriatal dopaminergic system in MPTP-induced mouse model of Parkinson's disease]. (1990)

C57BL/6 mice show decreased dopaminergic fibers and dopamine concentration in the striatum following systemic injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). We have investigated the effect of adrenal medullary grafts into the striatum of young mice treated with MPTP. Enhanced recovery of the host nigrostriatal dopaminergic system was observed in those adrenal medullary grafted mice. However, this recovery was influenced by the survivability of grafted chromaffin cells and adrenal chromaffin cells from younger donors survived better than those from older donors. Since adrenal chromaffin cells contain several kinds of neurotrophic factors such as basic fibroblast growth factor and gangliosides, survivability of those grafted chromaffin cells may play an important role concerning recovery of the host intrinsic dopaminergic fibers. Adrenal medullary grafts to the patients with Parkinson's disease are currently under way in a large number of hospitals and we suggest more consideration be given to methods which lead to enhance the grafted chromaffin cell survival, since those survivability might be closely related to the functional recovery of these patients.
On the Profitability of Long-Life Customers in a Noncontractual Setting: An Empirical Investigation and Implications for Marketing (2000)

Relationship marketing emphasizes the need for maintaining long-term customer relationships. It is beneficial, in general, to serve customers over a longer time, especially in a contractual relationship. However, it is not clear whether some of the findings observed in a contractual setting hold good in noncontractual scenarios: relationships between a seller and a buyer that are not governed by a contract or membership. The authors offer four different propositions in this study and subsequently test each one in a noncontractual context. The four propositions relate to whether (1) there exists a strong positive customer lifetime–profitability relationship, (2) profits increase over time, (3) the costs of serving long-life customers are less, and (4) long-life customers pay higher prices. The authors develop arguments both for and against each of the propositions. The data for this study, obtained from a large catalog retailer, cover a three-year window and are recorded on a daily basis. The empirical findings observed in this study challenge all the expectations derived from the literature. Long-life customers are not necessarily profitable customers. The authors develop plausible explanations for findings that go against the available evidence in the literature and identify three indicators through discriminant analysis that can help managers focus their efforts on more profitable customers. The authors draw several marketing implications and acknowledge the limitations of the study.
Variants in the Ghrelin Gene Are Associated with Metabolic Syndrome in the Old Order Amish (2005)

The allele frequencies of these variants were 0.03, 0.04, and 0.03, respectively. The prevalence of metabolic syndrome was lower among those carrying the 51Gln allele (3.8 vs. 15.8%; age- and sex-adjusted odds ratio = 0.22; P = 0.031). Hunger scores tended to be lower among 51Gln allele carriers but did not reach statistical significance (P = 0.07). The Leu72Met variant was also associated with increased prevalence of metabolic syndrome (23.2 vs. 13.4%; age- and sex-adjusted odds ratio = 2.57; P = 0.02) as well as higher fasting glucose, lower high-density lipoprotein, and higher triglyceride levels (P = 0.02, P = 0.007, and P = 0.04, respectively). The two variants were not in linkage disequilibrium with each other, suggesting independent effects. We conclude that mutations in GHRL may confer risk for the metabolic syndrome.
Human Schwann Cells in Tissue Culture Histochemical and Ultrastructural Studies (1980)

Schwann cells cultures were established from 40 human peripheral nerves that underwent biopsy according to an explant-reexplantation technique that markedly reduces non-Schwann cells and achieves cultures greatly enriched in Schwann cells suitable for a wide range of studies. Described are the growth characteristics and histochemical, ultrastructural, and ultrastructural-cytochemical patterns of normal human cultured Schwann cells from 12 patients with demonstrable peripheral nerve abnormality. These findings serve as a basis of comparison when seeking abnormalities of Schwann cells grown from peripheral nerves of patients with putative dysschwannian neuropathies.
Microwave Magnetic Properties of NiFe Nanostrips (2009)

The dynamic excitations in the nano-sized Permalloy arrays exhibit a strong resonance mode in ferromagnetic resonance experiments (conventional as well as network analyzer based) for the magnetic field applied in the plane of the array and along the short axis and long axis of the arrays. In network-analyzer experiments, when the dc field was applied along the short axis of the arrays, the resonance frequency goes down with an increasing interstrip distance up to 1 mum and then saturates for higher values. This behavior clearly demonstrates the presence of dipolar interactions between the individual elements, resulting in the increased resonance frequency for the smaller spacing whereas when the field is applied along the long axis, the resonance frequencies go up with increasing interstrip distance.
<title>Extraction of laser rate equation parameters</title> (1999)

A technique for the extraction of laser rate equation parameters to be used in the simulation of high-speed optical telecommunication systems is described. The simulation using the extracted parameters exhibits good agreement with the experimental results, even for a large current modulation and soliton pulses. A model, which represents the parasite effect introduced by the mount fixture, was built. The model presented here is ready to use in the simulation of high-speed lightwave systems.
Synthesis and Properties of Dextran-Linked Ampicillin (2001)

Ampicillin was coupled to dextran of average molecular weight 9,000 or 81,200 via the cyanogen bromide method. The degree of drug substituted per glucose unit (DSG) was varied from 0.104 to 0.028 (by weight bases: 22.1-5.9%) depending on the ratio of the reactants. Water solubility of dextran-linked ampicillin increased compared with free ampicillin, and the solubility decreased as the amount of ampicillin substituted increased. Plasma concentration of ampicillin, which appeared after intravenous administration of dextran-linked ampicillin in rats, was higher than when free ampicillin was administered, and the more so, the higher the molecular weight of dextran. Plasma half-life of dextran-linked ampicillin was two times longer than that of free ampicillin in rats. Antibacterial activities of dextran-linked ampicillin were evaluated against Staphylococcus aureus, Bacillus substillis, and Escherichia coli at two concentration levels according to the cup-plate method by measuring the diameter of inhibition zone, which was comparable to that of free ampicillin.
Herpes Simplex Virus Type 2 Serostatus Is Not Associated with Inflammatory or Metabolic Markers in Antiretroviral Therapy-Treated HIV (2014)

Systemic inflammation and immune activation may persist in HIV-infected persons on suppressive combination antiretroviral therapy (cART) and contribute to adverse health outcomes. We compared markers of immune activation, inflammation, and abnormal glucose and lipid metabolism in HIV-infected adults according to herpes simplex virus type 2 (HSV-2) serostatus in a 6-month observational cohort study in Toronto, Canada. HIV-infected adults on suppressive (viral load <50 copies/ml) cART were categorized as HSV-2 seropositive or seronegative using the HerpeSelect ELISA, and underwent study visits at baseline, 3 months, and 6 months. The primary outcome was the median percentage of activated (CD38(+)HLADR(+)) CD8 T cells. Secondary outcome measures included additional immune (activated CD4, regulatory T cells) and inflammatory (hsCRP, D-dimer, IL-1b, IL-6, MCP-1, TNF, sICAM-1, sVCAM-1, Ang1/Ang2 ratio) markers. Metabolic outcomes included the proportion with impaired fasting glucose/impaired glucose tolerance/diabetes, insulin sensitivity (calculated using the Matsuda index), insulin resistance (homeostasis model assessment of insulin resistance), and fasting lipids. The impact of HSV-2 on each outcome was estimated using generalized estimating equation regression models. Of 84 participants, 38 (45%) were HSV-2 seropositive. HSV signs and symptoms were uncommon. Aside from D-dimer, which was more often detectable in HSV-2 seropositives (adjusted odds ratio=3.58, 95% CI=1.27, 10.07), HSV-2 serostatus was not associated with differences in any other immune, inflammatory cytokine, acute phase reactant, endothelial activation, or metabolic markers examined in univariable or multivariable models. During the study, CD8 and CD4 T cell activation declined by 0.16% and 0.08% per month, respectively, while regulatory T cells increased by 0.05% per month. HSV-2 serostatus was not consistently associated with immune activation, inflammatory, or lipid and glucose metabolic markers in this cohort of HIV-infected adults on suppressive cART.
IMPROVEMENT IN ERECTILE DYSFUNCTION AFTER NEUROTROPHIC FACTOR GENE THERAPY IN DIABETIC RATS (2005)

We report that gene therapy for the treatment of diabetic ED is feasible with HSV vectors. NT3 gene therapy may be applicable for the treatment of ED induced by DM.
Chemical and chemotaxonomical studies of ferns. XXXIX. Chemical studies on the constituents of Pteris bella Tagawa and Pteridium aquilinum subsp. wightianum (Wall) Shich. (1982)

From the fronds of Pteris bella, three new pterosin-type compounds, I, III and XI, were isolated along with pterosins B (VI), C (II), Q (VII) and T (IV), setulosopterosin (X), pterosin C 3-O-β-D-glucoside (IX) and pterosin Q 3-O-β-D-glucoside (VIII). From the fronds of Pteridium aquilinum subsp. wightianum, two new pterosin-type compounds, XVI and XVII, were isolated along with pterosins C (II), D (XVIII), F (XXII), H (XX), I (XXI) and Z (XIX) and astragalin (XXIII). The structures of the new compounds were determined on the basis of chemical and spectral data.
Prospective of 31P MR Spectroscopy in Hepatopancreatobiliary Cancer: A Systematic Review of the Literature (2022)

3 TECHNICAL EFFICACY: Stage 2.
Magnetostrictive offset and noise in flux gate magnetometers (1969)

Longitudinal magnetostriction of the core material is found to be the principal source of offset and noise in present state-of-the-art flux gate magnetometers. Magnetostrictive offset is identified with even harmonics of the steady-state induced EMF resulting from the periodic elongation (or contraction) of the core material. Magnetostrictive noise is identified with random fluctuations of the magnetostrictive offset caused by frictional forces exceeding the magnetostrictive stress when the core material is near zero elongation. An analytical model and experimental results of magnetostrictive offset and noise are presented. It is expected that flux gate magnetometers with zero magnetostriction of the core material will yield a significant increase in signal-to-noise ratio with corresponding decreases in offset and magnetomotive drive power.
The Impact of Network State AoI on Throughput in a Wireless SDN (2022)

This work studies the role of Age of Information (AoI) in the network state updating process for wireless software defined networks (SDN). The SDN routers must routinely update their knowledge of the network state, which is used as a basis for making routing and scheduling decisions. However, the network updates require communication resources, so there is a tradeoff between the frequency of updates and maximum network throughput. We assume the network state is Markovian and no new observations are received in between updates, so the AoI of the network state information impacts the ability of the network to optimize its performance. We formulate the problem as a finite-horizon Partially Observable Markov Decision Process (POMDP) for each period. For a symmetric fading model of the network, we derive the limiting performance and an upper bound. To generate policies for a range of fixed time horizons, we use Monte Carlo planning-based POMDP solvers. Simulation of these policies show that there is a finite optimal update period that maximizes network throughput. In addition, we study non-uniform update intervals, which can yield even higher throughput if the interval is chosen based on the state observed. We conclude that AoI itself is not sufficient to characterize performance, but what matters is the AoI for the specific network state information.
Ultrasonic Measurement of Aircraft Strut Hydraulic Fluid Level (2002)

&lt;div class="htmlview paragraph"&gt;An ultrasonic method is presented for non-intrusively measuring hydraulic fluid level in aircraft struts in the field quickly and easily without modifying the strut or aircraft. The technique interrogates the strut with ultrasonic waves generated and received by a removable ultrasonic transducer hand-held on the outside of the strut in a fashion that inthe presence or absence of hydraulic fluid inside the strut. This technique was successfully demonstrated on an A-6 aircraft strut on the carriage at the Aircraft Landing Dynamics Research Facility at NASA Langley Research Center. Conventional practice upon detection of strut problem symptoms is to remove aircraft from service for extensive maintenance to determine fluid level. No practical technique like the method presented herein for locating strut hydraulic fluid level is currently known to be used.&lt;/div&gt;
Localization and characterization of the sn-glycerol-3-phosphate acyltransferase in Rhodopseudomonas sphaeroides. (1984)

The membrane localization and properties of the Rhodopseudomonas sphaeroides sn-glycerol-3-phosphate acyltransferase have been examined utilizing enzymatically prepared acyl-acyl carrier protein (acyl-ACP) substrates as acyl donors for sn-glycerol-3-phosphate acylation. Studies conducted with membranes prepared from chemotrophically and phototrophically grown cells show that sn-glycerol-3-phosphate acyltransferase activity is predominantly (greater than 80%) associated with the cell's cytoplasmic membrane. Enzyme activity associated with the intracytoplasmic membranes present in phototrophically grown R. sphaeroides was within the range attributable to cytoplasmic membrane contamination of this membrane fraction. Enzyme activity was optimal at 40 degrees C and pH 7.0 to 7.5, and required the presence of magnesium. No enzyme activity was observed with any of the long-chain acyl-CoA substrates examined. Vaccenoyl-ACP was the preferred acyl-ACP substrate and vaccenoyl-ACP and palmitoyl-ACP were independently utilized to produce lysophosphatidic and phosphatidic acids. With either vaccenoyl-ACP or palmitoyl-ACP as sole acyl donor substrate, the lysophosphatidic acid formed was primarily 1-acylglycerol-3-phosphate and the Km(app) for sn-glycerol-3-phosphate utilization was 96 microM. The implications of these results to the mode and regulation of phospholipid synthesis in R. sphaeroides are discussed.
Thermodynamic parameters of vaporization of EuBr2 (2010)

The vaporization process of europium dibromide was studied using high-temperature mass spectrometry. It was ascertained that saturated vapor in temperature range of 1049–1261 K was represented mainly by EuBr2 molecules; the fraction of dimer molecules Eu2Br4 was less than 1%. Heat capacities of solid and liquid europium dibromide, as well as the melting enthalpy were measured by means of differential scanning calorimetry in temperature range 300–1100 K; using these data thermodynamic functions for EuBr2 in condensed state were calculated. For all experimental data, including the literature data, thermodynamic characteristics of the vaporization of europium dibromide were determined using a unified set of thermodynamic functions according to the methods of the second and third laws of thermodynamics. The value of Δs H o(298.15 K) = 354 ± 5 kJ/mol was recommended for the reaction of sublimation of EuBr2(cr.) = EuBr2.