gebhart/patrepeval huggingface dataset:
Amplification and Hormone-Regulated Expression of a Mouse Mammary Tumor Virus-Eco gpt Fusion Plasmid in Mouse 3T6 Cells (1983)

Mouse 3T6 cells were transformed with a chimeric DNA plasmid, pSVMgpt, in which the mouse mammary tumor virus (MMTV) promoter was fused to the Escherichia coli gene encoding xanthine-guanine phosphoribosyl transferase (Eco gpt). The transformants exhibited glucocorticoid-inducible expression of Eco gpt. With limiting xanthine concentrations, conditions were established in which cell growth became hormone dependent. Cells selected for their ability to grow in limiting concentrations of both xanthine and glucocorticoids contained amplified levels of Eco gpt DNA, and expression of Eco gpt remained glucocorticoid inducible in these amplified cells. Thus, amplification of the MMTV promoter region in itself did not abolish hormonal responsiveness of a gene. In addition to increased levels of Eco gpt DNA, some of the selected cells also exhibited increased levels (two- to threefold) of glucocorticoid receptors. Lastly, we found that excessive expression of Eco gpt is toxic to 3T6 cells; by maintaining low hormone levels and, therefore, low levels of expression, we were able to select cells with amplified Eco gpt. Thus, the MMTV promoter may be of general utility in expressing genes whose products may be lethal if they are produced in excessive quantities.
ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing (2021)

ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago. Nevertheless, little was known about its impacts on the transcriptome, and potential functional overlap with its paralogs. Building on our recent findings that neural-specific lengthened 3' UTR isoforms are co-determined by ELAV/Hu factors, we address their impacts on splicing. While only a few splicing targets of Drosophila are known, ectopic expression of each of the three family members (Elav, Fne and Rbp9) alters hundreds of cassette exon and alternative last exon (ALE) splicing choices. Reciprocally, double mutants of elav/fne, but not elav alone, exhibit opposite effects on both classes of regulated mRNA processing events in larval CNS. While manipulation of Drosophila ELAV/Hu RBPs induces both exon skipping and inclusion, characteristic ELAV/Hu motifs are enriched only within introns flanking exons that are suppressed by ELAV/Hu factors. Moreover, the roles of ELAV/Hu factors in global promotion of distal ALE splicing are mechanistically linked to terminal 3' UTR extensions in neurons, since both processes involve bypass of proximal polyadenylation signals linked to ELAV/Hu motifs downstream of cleavage sites. We corroborate the direct action of Elav in diverse modes of mRNA processing using RRM-dependent Elav-CLIP data from S2 cells. Finally, we provide evidence for conservation in mammalian neurons, which undergo broad programs of distal ALE and APA lengthening, linked to ELAV/Hu motifs downstream of regulated polyadenylation sites. Overall, ELAV/Hu RBPs orchestrate multiple broad programs of neuronal mRNA processing and isoform diversification in Drosophila and mammalian neurons.
Graph Transformations for the Resource Description Framework (2024)

The Resource Description Framework (RDF) is a standard developed by the World Wide Web Consortium (W3C) to facilitate the representation and exchange of structured (meta-)data in the "SemanticWeb". While there is a large body of work dealing with inference on RDF, a concept for transformation and manipulation is still missing. Since RDF uses graphs as a formal basis, this paper proposes the use of algebraic graph transformations with their wealth of well-known constructions and results for this purpose. It turns out that RDF graphs are an interesting application area for graph transformation methods, where some significant differences to classical graphs yield practically relevant solutions for features like attribution, typing and globally unique nodes.
Simple electrocardiographic measures improve sudden arrhythmic death prediction in coronary disease (2020)

https://clinicaltrials.gov/ct2/show/NCT01114269. ClinicalTrials.gov ID NCT01114269.
Fourier optical realization of cellular neural networks (1993)

Cellular neural networks (CNNs) consist of analog, nonlinear, dynamic processing elements which are locally interconnected. Most applications in the areas of image processing, pattern recognition and robot control require interconnections between all elements which are space invariant. This suggests an optical CNN implementation because optical processors are perfectly suited for both space invariant signal processing and complete interconnections between all elements. The theoretical and practical aspects of a hardware realization are described. The results of an optical CNN performing feature extraction are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The predictive value of body protein for chemotherapy-induced toxicity (2000)

In this small group of breast carcinoma patients, the NI was found to be the most powerful predictor of neutropenia after CMF-based chemotherapy. The authors conclude that NI may be a useful clinical tool in identifying patients at a higher risk of chemotherapy-induced toxicity when widely distributed drug combinations such as CMF are used, and warrants further study with other commonly used drugs or drug regimens.
Analysis of the High Occupational Radiaton Works in CANDU in Korea (2006)

In Wolsong, Republic of KOREA, 4 units of CANDU are in operation. The total Power is 2779MWe(679, 700, 700, 700). Each plant has been operating since 1983, 1997, 1998, and 1999 respectively. And the total operation-year of KOREA has been reached to 41 reactor-years. Among them, first unit of Wolsong has been operated over 20 year. According to plant's aging, the occupational radiation exposure is expected to be increased because of frequent repairing works and accumulation of radioactivity of primary system. Owing to the tendency to strengthen the regulation of radiation exposure, the importance of dose reduction is increasing. In compliance with 'ALARA(as low as reasonably achievable)' concept, cost-effective dose reduction is necessary. The cost-effective reduction of ORD(occupational radiation dose) at a NPP could not be achieved without going through an extensive analysis of accumulated ORD data of existing plants. Therefore, the status of ORD in Wolsong 1 4 unit was analysed in this study. On the basis of this assessment, high occupational radiation works are identified.
Bond strength of Y‐TZP–zirconia ceramics subjected to various surface roughening methods and layering porcelain (2010)

Abstract The interface between yttrium oxide partially stabilized tetragonal zirconia polycrystalline (Y‐TZP) core and veneering porcelain is the site of most clinical failures. Many efforts have focused on increasing the bond strength between Y‐TZP core and veneering porcelain, and such approaches include increasing the surface roughness and providing undercuts. However, each surface roughening method carries limitations. The specific aim of this study was to test the bond strengths of Y‐TZP subjected to different methods (sandblasting, fine polising, and rough polising) and of veneering porcelain. Presintered zirconia blocks with rectangular parallelepiped shape were prepared, and the surfaces were roughened with different methods before sintering. Shear strength of each zirconia–veneer interface was measured from 15 specimens. The surface at the fractured areas after shear test was investigated using an optical microscope. In conclusion, Y‐TZP subjected to sandblasting showed inferior shear strength compared to other groups. Cohesive fracture was observed in the sandblasting group; combination of cohesive and adhesive fracture was observed in the control, fine polishing, and rough polishing groups. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Light-induced cell separation in a tailored optical landscape (2005)

We demonstrate passive optical sorting of cell populations in the absence of any externally driven fluid flow. Specifically, we report the movement of erythrocytes and lymphocytes in an optical landscape, consisting of a circularly symmetric light pattern created by a Bessel light beam. These distinct cell populations move, spontaneously and differentially, across the underlying periodic optical landscape. Thus, we were able to separate lymphocytes from a mixed population of cells containing erythrocytes and then collect the lymphocytes in a microcapillary reservoir. We also demonstrate an enhanced form of this separation that exploits the polarizability of silica microspheres by attaching spheres coated with antibodies to cell surface markers to a subpopulation of lymphocytes. These techniques may be applied using standard laboratory apparatus.
An integrated LED reflector for backlight system (2008)

An edge-backlight unit (EBLU) is applied as the light device to provide uniform light of liquid crystal display (LCD). Generally, the cathode cold fluorescent lamp (CCFL) is employed as the light source of BLU. With the advantages such as long durability, no mercury substance and good endurance of heavy impact, the light emitting diode (LED) is now accepted well known as available device for solid state lighting. To achieve the market requirement of the thin-film liquid crystal display (LCD) and the green-level product, the LED is replaced with the CCFL used in monitor in order to make display thinner, lighter, no Hg containing. In this paper, the integrated LED reflector is proposed because it enables the point-like light to distribute propagating-light line pattern successfully. To optimize the size and the radian of the reflector, our designed integrated LED reflector can achieve an optical efficiency more than 85%, and its light output length is 11 times of the input light source. Therefore, the integrated LED reflector not only can decrease the number of LED to save the built space, but also enhance the output efficiency. In the future, an integrated LED reflector could make displays thinner and brighter for backlight applications.
A side-by-side comparison of two systems of sequencing coupled reactors for anaerobic digestion of the organic fraction of municipal solid waste (2005)

The objective of this work was to compare the performance of two laboratory-scale, mesophilic systems aiming at the anaerobic digestion of the organic fraction of municipal solid wastes (OFMSW). The first system consisted of two coupled reactors packed with OFMSW (PBR1.1-PBR1.2) and the second system consisted of an upflow anaerobic sludge bed reactor (UASB) coupled to a packed reactor (UASB2.1-PBR2.2). For the start-up phase, both reactors PBR 1.1 and the UASB 2.1 (also called leading reactors) were inoculated with a mixture of non-anaerobic inocula and worked with leachate and effluent full recirculation, respectively. Once a full methanogenic regime was achieved in the leading reactors, their effluents were fed to the fresh-packed reactors PBR1.2 and PBR2.2, respectively. The leading PBR 1.1 reached its full methanogenic regime after 118 days (Tm, time to achieve methanogenesis) whereas the other leading UASB 2.1 reactor reached its full methanogenesis regime after only 34 days. After coupling the leading reactors to the corresponding packed reactors, it was found that both coupled anaerobic systems showed similar performances regarding the degradation of the OFMSW. Removal efficiencies of volatile solids and cellulose and the methane pseudo-yield were 85.95%, 80.88% and 0.109 NL CH4 g(-1) VS(fed) in the PBR-PBR system; and 88.75%, 82.61% and 0.115 NL CH4 g(-1) VS(fed0 in the UASB-PBR system [NL, normalized litre (273 degrees K, 1 ata basis)]. Yet, the second system UASB-PBR system showed a faster overall start-up.
Metal-bound chlorine often accepts hydrogen bonds (1998)

Analysis of 6624 crystallographically characterised hydrogen bonds containing M–Cl, C–Cl or Cl– and either HO or HN groups show that M–Cl moieties are good, anisotropic hydrogen-bond acceptors forming hydrogen bonds similar in length to those of the chloride anion, while C–Cl moieties are very poor hydrogen-bond acceptors.
Long‐term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty (2000)

PV appears to be a safe and useful procedure for the treatment of focal back pain secondary to osteoporotic vertebral fracture when conservative treatment has failed.
Protective effects of polydatin against CCl4-induced injury to primarily cultured rat hepatocytes (1999)

AIM:To investigate the protective effects of polydatin (PD) against injury to primarily cultured rat hepatocytes induced by CCl(4).METHODS:Rat hepatocytes were separated by methods of liver infusion in vivo and cultured medium (7.5X10(5) cells/mL). Two mL or 0.2mL was added into 24-well or 96-well plates respectively. Twenty-four hours after cell preculture, PD at concentrations of 10(-7) mol/L-10(-4)mol/L was added into each plate. At the same time injury to hepatocytes was induced by adding 10mmol/L CCl(4).Then, 0.1mL or 1mL culture solution was removed from the 96-well or 24-well plates at 6h, 12h, 24h and 48h after CCl14 intoxication respectively for the determination of GPT, GSH and MDA. At 48h, the survivability of rat hepatocytes was assayed by the MTT colormetric method.RESULTS:After CCl(4) challenge, the release of GPT and the formation of MDA in rat hepatocytes markedly increased and maintained at a high level in 48h, whereas PD with different concentrations could markedly inhibit this elevation with 10(-5)mol/L PD having the strongest effects and inhibiting rate was over 50%. PD could also improve the decreased content of GSH caused by CCl(4) in accordance with the doses used. CCl(4) evidently decreased the hepatocyte survivability from 91.0% ± 7.9% to 35.4% ± 3.8%. On the other hand, PD at 10(-7)mol/L-10(-4)mol/L could reverse this change and improve the cell survival rates to 56.1% ± 5.2%, 65.8% ± 5.0%, 88.7% ± 6.8% and 75.2% ± 7.3%, respectively.CONCLUSION: PD at 10(-7)mol/L-10(-4)mol/L could protect primarily cultured rat hepatocytes against CCl(4) induced injury.
Miniaturized optical system based on digital holography (2004)

A miniaturized system based on digital holographic inteferometry has been developed and used for the measurement of dynamical deformations, where measurements need to be performed at "hidden" surfaces or inside more or less closed objects. A Q-switched pulsed laser is used. Two digital holograms of the test object, corresponding to the two laser pulses, are captured at separate video frames of the CCD-camera, transferred in a frame grabber and further processed in a PC. If during the interval between the two laser pulses (usually in the range of 5 - 600 &mu;s) the object undergoes a vibration, a fringe pattern will result from the difference between the two holograms. This fringe pattern has the information needed to quantitatively evaluate the vibration.
Challenges and Opportunities of Future Rural Wireless Communications (2021)

Broadband access is key to ensuring robust economic development and improving quality of life. Unfortunately, the communication infrastructure deployed in rural areas throughout the world lags behind its urban counterparts due to low population density and economics. This article examines the motivations and challenges of providing broadband access over vast rural regions, with an emphasis on the wireless aspect in view of its irreplaceable role in closing the digital gap. Applications and opportunities for future rural wireless communications are discussed for a variety of areas, including residential welfare, digital agriculture, and transportation. This article also comprehensively investigates current and emerging wireless technologies that could facilitate rural deployment. Although there is no simple solution, there is an urgent need for researchers to work on coverage, cost, and reliability of rural wireless access.
Thermochemical properties of Group IVB and VB transition metal alloys with platinum group metals: acid-base stabilization (1986)

Solid-state galvanic cell measurements and oxide equilibration experiments are used to derive thermochemical quantities for a variety of acid-base stabilized alloys such as Nb-Pd, Nb-Rh, Ti-Pd, and Ti-Rh.The experiments have effectively resulted in the titration of palladium by niobium metal.The excess partial molar Gibbs energy of niobium at infinite dilution was determined to be -62 kcal/mole at 1000 C and the Gibbs energy of formation of NbPd 3 .55 is -42 kcal/mole.These results and those for the other systems are used to assess the importance of crystal field effects in the context of the generalized Lewis acid-base theory.The ternary phase diagrams for the Pd-Nb-0 and Rh-Nb-0 systems were obtained from the characterization of samples equili-brated at 1000 C. Powder X-ray diffraction patterns were measured for several equilibrium oxides that are substoichiometric of Nb 2 0 5 and are found to be consistent with crystal structures previously determined from single crystals of similar composition.An improved method was developed for composition measurements of binary metallic alloy grains using energy dispersive X-ray analysis and a scanning electron microscope.The effects of different processing methods were also explored in the preparation of optically transparent yttria doped thoria (YDT) pellets, and techniques for the preparation of reliable YDT solid electrolytes are presented... ~~ The Gibbs energy change can be fit to D.G = -75290 + 19.95T(1-13) and D.H 2 ~8 is -73540 cal/mole.The tabulated values for the Gibbs energy func- tions of Nb0 2 and 0 2 can be used to obtain gef for Nb 2 0 4 .8 as a function of This expression was used to evaluate the entries in table (1-I).
Supplementary Figure 4 from Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures (2023)

&lt;p&gt;PDF file - 1038K, Systems networks of AKT (A), apoptosis (B), IGF-1R (C) and mTOR (D) pathway activation. Node color: Violet - node representing the Pathway Score; Blue - phosphoproteins (linked to pathway score or to other proteins/genes at the protein level); Yellow - genes (linked to Pathway Score or to other proteins/genes at the mRNA level); Orange - microRNA; Dark green - drug; Light green - metabolite; Gray - other. Node shape: Diamond - Pathway Score node, or phosphoprotein that is used in calculating the Pathway Score; Circle - other nodes. Edge color &amp; label: Brown - relationship inferred based on phosphoprotein level (either with level other phosphoprotein, or with Pathway Score); Gray - relationship inferred based on gene mRNA expression (either with mRNA of other gene, or with Pathway Score); Dark green - phosphoprotein level or gene expression (mRNA) is significantly correlated with drug's response measured as -log(GI50); Light green - phosphoprotein level or gene expression (mRNA) is significantly correlated with metabolite concentration; Red - phosphoprotein level or gene expression (mRNA) is significantly correlated with mutation of other gene. Arrow points from mutation gene to the mRNA gene; Pink - gene expression (mRNA) is significantly correlated with methylation of other gene. Arrow points from methylation gene to the mRNA gene; Dark blue - gene expression (mRNA) is significantly correlated with copy number of other gene. Arrow points from copy number gene to the mRNA gene; Orange - gene expression (mRNA) is significantly correlated with expression of microRNA. Edge line style: Solid - positive correlation; Dashed - negative correlation.&lt;/p&gt;
Evaluation data and prototype system WISDOM for information credibility analysis (2008)

Purpose – The purpose of this paper is to describe evaluation data and a prototype system named WISDOM used for analyzing information credibility based on natural language processing.
Employees need role in design of work space. (1980)

Program involves entire staff in the planning of changes in the working environment, with resultant improvement in morale.
Safety and Adverse Events Profiles of Intravenous Gammaglobulin Products Used for Immunomodulation (2006)

Intravenous Ig (IVIg) products are used in various medical conditions. Differences in excipients account for most adverse events (AE). Reports of complications including acute myocardial infarction (AMI) and acute renal failure (ARF) have emerged. Herein is described one institution's experience with IVIg-related complications. This study is a retrospective analysis of infusion-related AE that are associated with various IVIg products. Infusion-related AE were monitored during and after the administration of three IVIg products: Gamimune-N 10% (n = 76), Polygam (n = 105), and Carimune (n = 98). AE segregated to specific IVIg products. No patients who received Gamimune-N experienced AMI or ARF. Five (4.7%) patients (P < 0.01) in the Polygam group experienced AMI. Eight (8.2%) patients (P < 0.0001) in the Carimune group developed ARF. IVIg was safe to give on hemodialysis. IVIg products differ in osmolality, pH, and sugar and sodium content; this results in specific AE. Polygam resulted in no ARF but an increase in AMI. Carimune products at 9% concentration resulted in an increase in ARF. Gamimune-N 10% and other IVIg products were frequently associated with headaches. Administration of IVIg to patients who are on hemodialysis seems to be safe and effective.
Application-oriented adaptive fuzzy design of ship's autopilot with rudder dynamics (2010)

By employing T-S fuzzy system to approximate uncertain functions, an adaptive fuzzy control algorithm was developed based on dynamic surface control and minimal-learning-parameter algorithm. With less learning parameters and reduced computation load, the proposed algorithm is convenient to be implemented in applications, and can avoid the possible controller singularity problem. In addition, the boundedness stability of the closed-loop system is guaranteed and the tracking error can be made arbitrarily small. Simulation results validate the effectiveness and the performance of the proposed scheme.
Video Sessions KPIs clustering framework in CDNs (2019)

Users' viewing experience in the video delivery process is of paramount importance for Content Delivery Networks (CDNs). Throughout their operations, CDN providers target the satisfaction of users' expectations in terms of Quality of Experience (QoE). In this context, CDN providers need to acquire knowledge on users' QoE and correlate observations through different video sessions in order to identify QoE degradations and investigate their potential root cause. In the absence of users' feedback on their QoE, CDN providers can monitor and analyze Key Performance Indicators (KPIs) throughout video sessions. This allows to assess the Quality of Service (QoS) offered to users, influencing their QoE. However, due to the large number of sessions handled by CDN operators, it is not possible to conduct such an analysis manually. In this work, we introduce a framework that allows to automatically group a large set of video sessions into a small number of representative clusters, with each cluster containing video sessions with similar patterns of KPIs. The framework builds upon a set of features representing the evolution of KPIs over a session. It relies on an unsupervised machine learning algorithm to form the clusters. We evaluate the framework over a real-world dataset with traffic logs relating to thousands of sessions. The obtained results underline the capabilities of the proposed framework.