gebhart/patrepeval huggingface dataset:
Long-Term Followup of a Large Cohort of Patients with Ovotesticular Disorder of Sex Development (2014)

Male gender assignment was more prevalent. Long-term followup revealed adequate pubertal development and sexual activity. Complications involving the urethra developed frequently in male patients.
New pleuromutilin derivatives with enhanced antimicrobial activity. II. Structure-activity correlations. (1976)

Structural modification of the antibiotic pleuromutilin has afforded several derivatives with considerably enhanced activity against bacteria and mycoplasmas, and has permitted conclusions to be reached about structure-activity relationships. The carbonyl group in the five-membered ring and the hydroxyl group at C11 seem to be essential for activity. The vinyl group can be hydrogenated without loss of activity. Chemical modification at C14 offers the most possibilities for achieving the best activity and solubility properties. Mutilin, and other compounds with a free OH at C14, are inactive. It was shown that mutilin esters of substituted thioglycolic acids had distinctly superior MIC values, especially in combination with a tertiary amino group in the side chain, the latter group of derivatives having MIC values better than pleuromutilin by a factor of more than 10. Further variation within this group led to the development of 14-deoxy-14-[(2-diethylaminoethyl) thioacetoxy]-mutilin hydrogen fumarate (81.723 hfu, tiamulin) for extensive investigation of its chemotherapeutic potential.
Transient Silylation of the Guanosine O6 and Amino Groups Facilitates N-Acylation (2004)

[reaction: see text] The formation of a guanosine derivative silylated at both the O6 and amino groups was identified by (15)N NMR. This intermediate allows facile reaction with acetyl chloride or phenoxyacetyl chloride to give in high yield the corresponding N-protected guanosine derivatives, suitable for use in RNA synthesis. The acetyl and phenoxyacetyl amino protecting groups are, respectively, 4 and 230 times more labile than the isobutyryl group to methylamine/ethanol deprotection.
Inexpensive schlieren video technique using sensor dead space as a grid (2004)

Schlieren photography normally uses a background light source grid or mirror system to send light through a sample area and a second grid or a knife edge at the camera to block nondeflected light. We describe a new technique that uses the inactive areas between CCD or CMOS sensor pixels as the second grid, so only a background grid is needed. This simplifies the setup and lowers the cost of the system.
EFFECT OF RADIATION DOSAGE ON EFFICIENCY OF CHLOROPLAST TRANSFER BY PROTOPLAST FUSION IN NICOTIANA (1982)

Chloroplasts of Nicotiana tabacum SR1 were transferred into Nicotiana plumbaginifolia by protoplast fusion. The protoplasts of the organelle donor were irradiated with different lethal doses using a (60)Co source, to facilitate the elimination of their nuclei from the fusion products. After fusion induction, clones derived from fusion products and containing streptomycin-resistant N. tabacum SR1 chloroplasts were selected by their ability to green on a selective medium. When N. tabacum protoplasts were inactivated by iodoacetate instead of irradiation, the proportion of N. plumbaginifolia nuclear segregant clones was low (1-2%). Irradiation markedly increased this value: Using 50, 120, 210 and 300 J kg(-1) doses, the frequency of segregant clones was 44, 57, 84 and 70 percent, respectively. Regeneration of resistant N. plumbaginifolia plants with SR1 chloroplasts indicated that plastids can be rescued from the irradiated cells by fusion with untreated protoplasts. Resistant N. plumbaginifolia plants that were regenerated (43 clones studied) had diploid (2n = 2X = 20) or tetraploid chromosome numbers and were identical morphologically to parental plants. The absence of aneuploids suggests that in these clones irradiation resulted in complete elimination of the irradiated N. tabacum nuclei. Resistance is inherited maternally (five clones tested). The demonstration of chloroplast transfer and the presence of N. tabacum plastids in the N. plumbaginifolia plants was confirmed by chloroplast DNA fragmentation patterns after EcoRI digestion.
Development of a Pre-Verified EPD Tool with Process Simulation Capabilities for the Aggregates Industry (2021)

This paper has two aims: to describe the current status and challenges of aggregates producers regarding the analysis and communication of environmental information of their products and to present a layout of a pre-verified tool with simulation capabilities that could assist aggregates producers with their environmental goals. Semi-structured interviews were conducted with three Swedish aggregates producers, an aggregates customer, and an expert agency. Additionally, published Environmental Product Declarations (EPDs) for aggregates and the EN 15804:2012 + A2:2019 were studied to reveal current practices and upcoming changes due to the updated standard. The synergies with process simulations were explored as a step towards using the EPD framework for continuous improvement of aggregates production. The interviews indicated that the main challenge for aggregates producers is the lack of easily available plant data for environmental calculations and clearly defined environmental goals at each plant. The proposed tool uses a common process flowsheet for both EPDs and simulations and has a pre-defined LCA module. The use of such a tool is expected to raise the environmental interest at aggregates plants and improve collaboration with LCA experts. Since the analysis is based on the Swedish aggregates market, the interview results are not directly generalizable to the European context.
Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics<SUBTITLE>The PCI-CLARITY Study</SUBTITLE> (2005)

Clopidogrel pretreatment significantly reduces the incidence of cardiovascular death or ischemic complications both before and after PCI and without a significant increase in major or minor bleeding. These data add further support to the early use of clopidogrel in STEMI and the strategy of routine clopidogrel pretreatment in patients undergoing PCI.
Unsaturated heterocyclic systems. LVI. Reaction of a mesocyclic dienamine with sulfene (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated heterocyclic systems. LVI. Reaction of a mesocyclic dienamine with sulfeneLeo A. Paquette and Robert W. BeglandCite this: J. Org. Chem. 1969, 34, 10, 2896–2900Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://pubs.acs.org/doi/10.1021/jo01262a019https://doi.org/10.1021/jo01262a019research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Echo cancellation with delay estimation (2002)

Echo cancellation research using digital signal processing (DSP) has been conducted for some time now. This paper presents some techniques for dealing with echoes where the delay time can range from very short, few milliseconds, to very long, on the order of hundreds of milliseconds. The algorithm developed and investigated as part of the research presented in this paper has also been designed for real-time implementation on Texas Instruments TMS320C3X family of floating-point DSP chips.
Redox‐Tunable Defects in Colloidal Photonic Crystals (2005)

Reversible tuning of an intragap transmitting state induced by redox cycling is accomplished using a redox-active polyelectrolyte multilayer planar defect embedded in a colloidal photonic crystal (CPC). The wavelength position of the defect state can be changed by changing the oxidation state of the ferrocene moieties in the polymer backbone (see Figure). This could find applications in electrochemically tunable microcavities and CPC-based laser sources.
Reactions Involved in the Conversion of Ornithine to Proline in Clostridia (1969)

An enzyme system which converts ornithine to proline was partially purified from extracts of cells of Clostridium botulinum and of Clostridium PA 3670 by fractionation with ammonium sulfate and by dialysis in the presence of 0.01 m ornithine. Nicotinamide adenine dinucleotide (NAD) was the only cofactor required for maximal activity of the partially purified system. A possible intermediate in the conversion was accumulated when a high concentration of proline was used as substrate and the NAD was maintained in the oxidized state by adding lactic dehydrogenase. Small but significant amounts of this or a similar compound were trapped with either ornithine or proline as substrate when o-aminobenzaldehyde was added to reaction mixtures. The accumulation of the o-aminobenzaldehyde reaction product was NAD-dependent with both substrates. The compound accumulated from proline was identified as Delta(1)-pyrroline-5-carboxylic acid on the basis of the melting point of the 2,4-dinitrophenylhydrazone, and by paper chromatography of the reaction product formed with o-aminobenzaldehyde. Also, extracts of C. botulinum cells oxidized reduced NAD (NADH) in the presence of the product from proline or in the presence of Delta(1)-pyrroline-5-carboxylic acid, but did not do so in the presence of the other possible intermediate, Delta(1)-pyrroline-2-carboxylic acid. (14)C-Delta(1)-pyrroline-5-carboxylic acid was reduced to (14)C-proline by these extracts in the presence of NADH. These data indicate that the conversion of ornithine to proline by C. botulinum and Clostridium PA 3679 cells involves an oxidation of ornithine to glutamic-gamma-semialdehyde which undergoes ring closure to Delta(1)-pyrroline-5-carboxylic acid. The latter compound is then reduced to proline.
ChemInform Abstract: HALOGENMETHYL‐METALL‐VERBINDUNGEN 55. MITT. DIE DARST. VON PHENYL‐(TRIFLUORMETHYL)‐QUECKSILBER DURCH FLUORIERUNG VON PHENYL‐(TRIBROMMETHYL)‐QUECKSILBER (1973)

Abstract Der über Phenylquecksilberhydroxid (II) aus dem Acetat (I) erhältliche Komplex (III) ist ein ausgezeichnetes Fluorierungsmittel, mit dem das Tribromid (IV) schon bei Zimmertemperatur in 65%iger Ausbeute, das Trichlorid (VI) jedoch erst bei erhöhter Temperatur in 55%iger Ausbeute in das Trifluorid (V) umgewandelt werden können.
Friction stir welding of single crystal aluminium (2007)

Friction stir welds were prepared in different orientations in an aluminium single crystal. The welds were quenched to preserve the microstructure surrounding the tool and then electron backscattered diffraction was used to reveal the generation of grain boundaries and the evolution of crystallographic texture around the tool in each weld. The extent of both dynamic recrystallisation and conventional recrystallisation varied considerably as a function of weld orientation. As the base plate begins to interact with the deformation field surrounding the tool, regions of the single crystal rotate to new crystal orientations, producing new grain boundaries in the process. These refined grains develop a {112}&lt;110&gt; texture closer to the tool. Large conventionally recrystallised grains sometimes form in the outer regions of the refined grain structure, but become ever more deformed as they approach the tool until they are indistinguishable from the surrounding material.
Response Time of Plated Thermocouple in Notched Well (1977)

Click to increase image sizeClick to decrease image sizeKEYWORDS: thermocouplesresponse timeplated thermocouplenotched well-type thermocouple
Multi-robot map building based on Ad hoc network communication (2011)

Multi-robot map-building most uses Dynamic partitioning method, which limits the mutual cooperation between the robots greatly. To solve the problem, this paper proposes an improved method of distributed control system based on Ad hoc Network to strengthen collaboration between the robots. The method builds the global coordinates, transfers and searches for the information and the position of roots using Ad hoc network to achieve information sharing and strengthen collaboration between the robots, and builds map using the grid method. The experimental results on the robot platform show the feasibility and effectiveness of the approach.
HDL Phospholipids, but Not Cholesterol Distinguish Acute Coronary Syndrome From Stable Coronary Artery Disease (2019)

Background Although acute coronary syndromes (ACS) are a major cause of morbidity and mortality, relationships with biologically active lipid species potentially associated with plaque disruption/erosion in the context of their lipoprotein carriers are indeterminate. The aim was to characterize lipid species within lipoprotein particles which differentiate ACS from stable coronary artery disease. Methods and Results Venous blood was obtained from 130 individuals with de novo presentation of an ACS (n=47) or stable coronary artery disease (n=83) before coronary catheterization. Lipidomic measurements (533 lipid species; liquid chromatography electrospray ionization/tandem mass spectrometry) were performed on whole plasma as well as 2 lipoprotein subfractions: apolipoprotein A1 (apolipoprotein A, high-density lipoprotein) and apolipoprotein B. Compared with stable coronary artery disease, ACS plasma was lower in phospholipids including lyso species and plasmalogens, with the majority of lipid species differing in abundance located within high-density lipoprotein (high-density lipoprotein, 113 lipids; plasma, 73 lipids). Models including plasma lipid species alone improved discrimination between the stable and ACS groups by 0.16 (C-statistic) compared with conventional risk factors. Models utilizing lipid species either in plasma or within lipoprotein fractions had a similar ability to discriminate groups, though the C-statistic was highest for plasma lipid species (0.80; 95% CI, 0.75-0.86). Conclusions Multiple lysophospholipids, but not cholesterol, featured among the lipids which were present at low concentration within high-density lipoprotein of those presenting with ACS. Lipidomics, when applied to either whole plasma or lipoprotein fractions, was superior to conventional risk factors in discriminating ACS from stable coronary artery disease. These associative mechanistic insights elucidate potential new preventive, prognostic, and therapeutic avenues for ACS which require investigation in prospective analyses.
Use of a Secure Internet Web Site for Collaborative Medical Research (2000)

Researchers who collaborate on clinical research studies from diffuse locations need a convenient, inexpensive, secure way to record and manage data. The Internet, with its World Wide Web, provides a vast network that enables researchers with diverse types of computers and operating systems anywhere in the world to log data through a common interface. Development of a Web site for scientific data collection can be organized into 10 steps, including planning the scientific database, choosing a database management software system, setting up database tables for each collaborator's variables, developing the Web site's screen layout, choosing a middleware software system to tie the database software to the Web site interface, embedding data editing and calculation routines, setting up the database on the central server computer, obtaining a unique Internet address and name for the Web site, applying security measures to the site, and training staff who enter data. Ensuring the security of an Internet database requires limiting the number of people who have access to the server, setting up the server on a stand-alone computer, requiring user-name and password authentication for server and Web site access, installing a firewall computer to prevent break-ins and block bogus information from reaching the server, verifying the identity of the server and client computers with certification from a certificate authority, encrypting information sent between server and client computers to avoid eavesdropping, establishing audit trails to record all accesses into the Web site, and educating Web site users about security techniques. When these measures are carefully undertaken, in our experience, information for scientific studies can be collected and maintained on Internet databases more efficiently and securely than through conventional systems of paper records protected by filing cabinets and locked doors. JAMA. 2000;284:1843-1849.
Thyrotropin stimulation of the AD) bovine thyroid membranes (adenylate cyclase/cholera toxin/thyrotropin receptor/desensitizatic (2016)

Thyrotropin increases the ADP-ribosylation ac- tivity of bovine thyroid membranes. Rapid ADP-ribosylation of membrane components is followed by increasing ADP-ribosyla- tion of components in the supernatant of the reaction mixture. One of the major membrane proteins ADP-ribosylated in the thyro- tropin-stimulated reaction has an approximate molecular weight of 40,000; this same protein is also a major ADP-ribosylated prod- uct of the A protomer of cholera toxin and appears to be related to the G regulatory subunit of the adenylate cyclase complex. The ADP-ribosylated products appearing in the supernatant solution comigrate with thyrotropin and preparations of 25I-labeled a sub- unit of thyrotropin; the a subunit, but not the /3 subunit, of thy- rotropin can be ADP-ribosylated by the membrane ADP-ribosyl- transferase activity. NAD can be shown to enhance the ability of thyrotropin to stimulate the adenylate cyclase activity of bovine thyroid membrane preparations and of membrane preparations of a rat thyroid tumor whose adenylate cyclase activity is otherwise unresponsive to thyrotropin. The Pf subunit of thyrotropin inhibits thyrotropin stimulation of both the ADP-ribosylation and ade- nylate cyclase activities of the thyroid membrane.
A high performance green-sensitive organic photodiode comprising a bulk heterojunction of dimethyl-quinacridone and dicyanovinyl terthiophene (2013)

A fullerene-free bulk-heterojunction (BHJ) organic photodiode (OPD) with high efficiency and green-color selectivity is reported. Using N,N-dimethyl quinacridone (DMQA) as a donor and dibutyl-substituted dicyanovinyl-terthiophene (DCV3T) as an acceptor, a maximum external quantum efficiency (EQE) of over 67% at 540 nm was achieved at −5 V bias. The OPD performance together with their electrical and optical behaviors were investigated by varying the ratio of donor and acceptor components and measuring the absorption coefficient, charge carrier generation, and charge transport. The composition rich in DMQA exhibited a high yield of photogenerated charge carriers and a low absorption intensity, whereas the material rich in DCV3T had a high absorption intensity and low yield of charge carriers. It was found that the 1 : 1 ratio of components showed the best device performance due to its relatively high absorption and efficient photogeneration of charge carriers. Furthermore, electrical characterization of our BHJ OPDs indicated that a balance of electron and hole mobilities is important for enhancing EQE.
Silent Speech Recognition as an Alternative Communication Device for Persons With Laryngectomy (2017)

Each year thousands of individuals require surgical removal of their larynx (voice box) due to trauma or disease, and thereby require an alternative voice source or assistive device to verbally communicate. Although natural voice is lost after laryngectomy, most muscles controlling speech articulation remain intact. Surface electromyographic (sEMG) activity of speech musculature can be recorded from the neck and face, and used for automatic speech recognition to provide speech-to-text or synthesized speech as an alternative means of communication. This is true even when speech is mouthed or spoken in a silent (subvocal) manner, making it an appropriate communication platform after laryngectomy. In this study, 8 individuals at least 6 months after total laryngectomy were recorded using 8 sEMG sensors on their face (4) and neck (4) while reading phrases constructed from a 2,500-word vocabulary. A unique set of phrases were used for training phoneme-based recognition models for each of the 39 commonly used phonemes in English, and the remaining phrases were used for testing word recognition of the models based on phoneme identification from running speech. Word error rates were on average 10.3% for the full 8-sensor set (averaging 9.5% for the top 4 participants), and 13.6% when reducing the sensor set to 4 locations per individual (n=7). This study provides a compelling proof-of-concept for sEMG-based alaryngeal speech recognition, with the strong potential to further improve recognition performance.
Non-contact mesoscale manipulation using laser induced convection flows (2008)

Laser induced convection flows is a new and promising method to achieve better manipulation of mesoscale objects (above 1 mum and below 500 mum) in a liquid medium. The temperature gradient created by laser absorption generates natural and thermocapillary (or Marangoni) convection flows. These flows are used to perform the manipulation itself. In this paper, we demonstrate for the first time that large and heavy particles can be dragged using the Marangoni convection flows. Experiments based on these phenomena show that fast and accurate underwater micromanipulation of particles up to 280 mum is possible using only a convergent 1480 nm laser beam.
Short and long-term physiological responses of male and female rats to two dietary levels of pre-gelatinized maca (lepidium peruvianum chacon). (2006)

Obtained results justify further clinical research on use of Maca-GO in sportsmen, physically-active people of both sexes and peri-menopausal women to clarify mechanisms underlaying physiological mode of action of Maca-GO validaet in clinical study on humans. Substantial decrease in blood cortisol levels in a short- and longer-term trial and simultaneous tendency to lower blood ACTH, may indicate antidepressive effect of Maca-GO, which together with reduction in body weight, lowering triglycerides in blood plasma and increasing calcium and phosphorus deposition in bone and muscle tissues is worthy consideration in potential application to women at both, pre- and postmenopausal stage.
Organic polymer composites as robust, non-covalent supports of metal salts (2009)

A novel organic polymer composite for the encapsulation of metal catalysts and applications to synthesis are described here.