gebhart/patrepeval huggingface dataset:
Pre- and postflight systolic time intervals during LBNP: the second manned Skylab mission. (1976)

After space flight of 59 d, Skylab 3 astronauts were stressed with lower body negative pressure (LBNP). During this stress procedure vectorcardiograms, pneumograms, phonocardiograms, and carotid pulse tracings were monitored and recorded onto analog tape. Accepted techniques were used to measure the intervals of systole. The postflight results were compared to multiple preflight tests and each of the three crewmen served as his own control. Immediately postflight, there were elevations in heart rate and blood pressure in response to a fixed level (-50 mm Hg) of LBNP. Total electromechanical systole, (Q-S2) I, was unchanged. Ejection time index (ETI) was depressed at rest and during stress, while pre-ejection period was elevated compared with preflight values. Systolic time intervals (STI) were within preflight limits after 1 month on earth in all crewmen. Resting STI returned sooner than did stressed STI. The magnitude and direction of STI in the postflight period were similar to those obtained from patients with moderate heart disease, although signs and symptoms were absent in the astronauts. However, the abnormality of the stressed STI persisted after both blood volume repletion and lowered afterload. These findings suggest a compromise in cardiac function, peripheral circulatory integrity, or both after exposure to long-duration space flight, and are consistent with findings reported after 3 weeks of absolute bedrest.
Self-assembly method of linearly aligning ZnO quantum dots for a nanophotonic signal transmission device (2010)

We report a self-assembly method that aligns nanometer-sized quantum dots (QDs) into a straight line along which photonic signals can be transmitted by optically near-field effects. ZnO QDs were bound electrostatically to DNA to form a one-dimensional QD chain. The photoluminescence intensity under parallel polarization excitation along the QDs chain was much greater than under perpendicular polarization excitation, indicating an efficient signal transmission along the QD chain. As optical near-field energy can transmit through the resonant energy level, nanophotonic signal transmission devices have a number of potential applications, such as wavelength division multiplexing using QDs of different sizes.
Transactional contention management as a non-clairvoyant scheduling problem (2006)

The transactional approach to contention management guarantees atomicity by making sure that whenever two transactions have a conflict on a resource, only one of them proceeds. A major challenge in implementing this approach lies in guaranteeing progress, since transactions are often restarted.Inspired by the paradigm of non-clairvoyant job scheduling, we analyze the performance of a contention manager by comparison with an optimal, clairvoyant contention manager that knows the list of resource accesses that will be performed by each transaction, as well as its release time and duration. The realistic, non-clairvoyant contention manager is evaluated by the competitive ratio between the last completion time (makespan) it provides and the makespan provided by an optimal contention manager.Assuming that the amount of exclusive accesses to the resources is non-negligible, we present a simple proof that every work conserving contention manager guaranteeing the pending commit property achieves an O(s) competitive ratio, where s is the number of resources. This bound holds for the GREEDY contention manager studied by Guerraoui et al. [2] and is a significant improvement over the O(s2) bound they prove for the competitive ratio of GREEDY. We show that this bound is tight for any deterministic contention manager, and under certain assumptions about the transactions, also for randomized contention managers.When transactions may fail, we show that a simple adaptation of GREEDY has a competitive ratio of at most O(ks), assuming that a transaction may fail at most k times. If a transaction can modify its resource requirements when re-invoked, then any deterministic algorithm has a competitive ratio Ω(ks). For the case of unit length jobs, we give (almost) matching lower and upper bounds.
Changes in health and disease of the metalloprotease that cleaves von Willebrand factor (2001)

Congenital or immunomediated deficiencies of the metalloprotease that cleaves physiologically von Willebrand factor (vWF) reduce or abolish the degradation of ultralarge vWF multimers that cause the formation of intravascular platelet thrombi in patients with thrombotic thrombocytopenic purpura (TTP). There is little knowledge on the behavior of the protease in other physiological and pathologic conditions. Such knowledge is important to evaluate the specificity of low protease plasma levels in the diagnosis of TTP. Using an enzyme immunoassay, the protease was measured in 177 control subjects of different ages, in 26 full-term newborns, and in 69 women during normal pregnancy. Because TTP is often associated with multiorgan involvement and acute phase reactions, clinical models of these pathologic conditions were also investigated, including decompensated liver cirrhosis (n = 42), chronic uremia (n = 63), acute inflammatory states (n = 15), and the preoperative and postoperative states (n = 24). Protease levels were lower in healthy persons older than 65 than in younger persons. They were low in newborns but became normal within 6 months, and they were lower in the last 2 trimesters of pregnancy than in the first. Protease levels were also low in patients with cirrhosis, uremia, and acute inflammation, and they fell in the postoperative period. There was an inverse relation between low protease and high plasma levels of vWF antigen and collagen-binding activity. In conclusion, low plasma levels of the vWF cleaving protease are not a specific beacon of TTP because the protease is also low in several physiological and pathologic conditions.
Multipath and ground clutter analysis for a UWB noise radar (2002)

An ultrawideband (UWB) random-noise radar operating in the 1-2 GHz frequency band has been developed and field-tested up to a 200 m range at the Environmental Remote Sensing Laboratory (ERSL) of the University of Nebraska. A unique heterodyne correlation technique based on a delayed transmitted waveform using a photonic delay line has been used to inject coherence within this system. The performance of this radar in the presence of ground reflections is investigated analytically and experimentally, and the mitigating effects of UWB waveform on multipath-induced interference are analyzed. In addition, the ground clutter statistics, in a look-down mode, are theoretically established and experimentally verified. The performance of this radar in detecting clutter embedded targets with small radar cross section (RCS) is also experimentally examined.
Sequencing Approaches for Personalized Cancer Therapy Selection in Pathology (2019)

The best treatment of each individual cancer patient starts with the best molecular pathological diagnosis. In routine pathology diagnostics the available tissue is most frequently Formalin Fixed Paraffin Embedded, resulting in suboptimal fragmented DNA. Within pathology diagnostics, two different trends occur simultaneously where, on one hand, larger gene panels are used to allow the analysis of different tumor types using one standardized gene panel. Although in medical genetics practice whole exome-sequencing (WES) is sometimes already replaced by WGS, pathology mainly uses targeted sequencing. In future cancer treatment we will need an extensive genetic makeup of the tumor to optimal predict, treat and monitor cancer. With decreasing sequencing costs and increased computational power, it is likely that WES and WGS will become practice in pathology. DNA/RNA sequencing will not only stay a leading assay for predicting response to targeted therapy.
Thermal characterization of materials using Karhunen–Loève decomposition techniques – Part II. Heterogeneous materials (2012)

International audience
Imaging the incipient electrochemical oxidation of highly oriented pyrolytic graphite (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImaging the incipient electrochemical oxidation of highly oriented pyrolytic graphiteCharles A. Goss, Jay C. Brumfield, Eugene A. Irene, and Royce W. MurrayCite this: Anal. Chem. 1993, 65, 10, 1378–1389Publication Date (Print):May 15, 1993Publication History Published online1 May 2002Published inissue 15 May 1993https://pubs.acs.org/doi/10.1021/ac00058a014https://doi.org/10.1021/ac00058a014research-articleACS PublicationsRequest reuse permissionsArticle Views914Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Addendum to “A structural classification of substrate‐binding proteins” [FEBS Lett. 584 (2010) 2606–2617] (2010)

Shortly after our publication, Dr. Gavin Thomas informed usthat four proteins (BugD, BugE, Bug27 and TT1099), belonging tothe TAXI and TTT families of TRAP-transporters[1–4], were miss-ing from our analysis. We then performed a DALI search[5] inaddition to the FFAS server and PSI-BLAST and detected 7 new pro-tein structures. Those are: BugD (PDB code: 2F5X), BugE (PDBcode: 2DVZ), Bug27 (PDB code: 2QPQ), TT1099 (PDB code: 1US5),a maltose-binding protein (TMBP (PDB code: 1EU8)) and two glu-tamate-binding proteins, GluR0 and DEBP (PDB codes: 1II5 and2VHA, respectively). The structural similarity analysis was redonewith in total 114 unique entries in the PDB, but the overall out-come was the same. The newly included proteins fall within thepreviously determined clusters: TMBP clustered with the other oli-gosaccharide-binding proteins in Cluster D, and the other six pro-teins fell in Cluster F.
Internet security and intrusion detection (2003)

The tutorial presents the principal attack techniques that are used in the Internet today and possible countermeasures. In particular, intrusion detection techniques are analyzed in detail. This tutorial mixes a practical character with a discussion of the current research in the field. Participants will learn how the security of networks is violated and how such violations can be detected and prevented.
Starter alternator in zero inertia configuration : expanding the functionality of the zero inertia drivetrain (2002)

In the present report a method for the practical noise measurement in the factory environment is developed. The acoustic noise present is normally composed of the noise emitted from several machines more or less simultaneously and the measurement problem often consists in determining an average noise level that is then compared with some accepted noise criteria and on the basis of this comparison decisions may be taken as to necessary changes in the environment. The method extends the dynamic referred to as "impulse" use, that is a characteristic meter response which closely approaches the rise time of the human ear and stores, averages and forgets the short duration signal in a way similar to that of the human brain. The measured average noise level gives a better explanation of the audiometrically detectable occupation noise-induced hearing loss.
Toxin Plasmids of Clostridium perfringens (2013)

In both humans and animals, Clostridium perfringens is an important cause of histotoxic infections and diseases originating in the intestines, such as enteritis and enterotoxemia. The virulence of this Gram-positive, anaerobic bacterium is heavily dependent upon its prolific toxin-producing ability. Many of the ∼16 toxins produced by C. perfringens are encoded by large plasmids that range in size from ∼45 kb to ∼140 kb. These plasmid-encoded toxins are often closely associated with mobile elements. A C. perfringens strain can carry up to three different toxin plasmids, with a single plasmid carrying up to three distinct toxin genes. Molecular Koch's postulate analyses have established the importance of several plasmid-encoded toxins when C. perfringens disease strains cause enteritis or enterotoxemias. Many toxin plasmids are closely related, suggesting a common evolutionary origin. In particular, most toxin plasmids and some antibiotic resistance plasmids of C. perfringens share an ∼35-kb region containing a Tn916-related conjugation locus named tcp (transfer of clostridial plasmids). This tcp locus can mediate highly efficient conjugative transfer of these toxin or resistance plasmids. For example, conjugative transfer of a toxin plasmid from an infecting strain to C. perfringens normal intestinal flora strains may help to amplify and prolong an infection. Therefore, the presence of toxin genes on conjugative plasmids, particularly in association with insertion sequences that may mobilize these toxin genes, likely provides C. perfringens with considerable virulence plasticity and adaptability when it causes diseases originating in the gastrointestinal tract.
Control of domain wall pinning by switchable nanomagnet state (2014)

We report on a novel approach to establish switchable pinning of magnetic domain walls in a nanowire with perpendicular magnetic anisotropy by a single in-plane magnetized single-domain nanomagnet positioned on top of the wire. Devices were prepared by depositing a permalloy nanomagnet on top of a nanowire formed from a Co/Ni multilayer with their long axes parallel, separated by a nonmagnetic layer. We show by electrical measurements that the domain wall pinning strength depends critically on the state of the bistable nanomagnet and can differ by more than 10 mT. We also performed micromagnetic calculations that show that the difference in pinning strength is caused by the interaction of the forced Néel wall with the nanomagnet's magnetostatic field.
Use of the Hollow Fiber Assay for the Discovery of Novel Anticancer Agents from Fungi (2012)

The hollow fiber assay (HFA) is a drug discovery tool to aid investigators in the prioritization of lead compounds identified by in vitro testing for further development in animal models of disease. In the HFA, cells are cultured in hollow fibers containing pores of a diameter (500 kDa) large enough for proteins and other macromolecules to enter, but too small for the cells to escape. The fibers are filled with cells, sealed and placed in the peritoneal cavity of immunodeficient mice. The mice undergo a predetermined treatment regimen after which the fibers are retrieved and the cells evaluated for activity of a target relevant to the disease modeled. The HFA combines advantages of both in vitro and in vivo assay systems. It uses the same cell lines used in culture systems, is a rapid assay, and requires fewer animals and less test substance than conventional xenograft systems. Like traditional in vivo assays, the test substance is evaluated in a live animal, which affords an initial assessment of associated toxicity and pharmacokinetic properties of the test substance.
Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants (1994)

We have previously identified a Plasmodium falciparum liver stage-specific Ag (LSA-1) found to encode tandem 17 amino acid repeats harboring B cell determinants. Here we extend this study in terms of sequence analysis, protein localization, and immunologic properties. Analysis of the N- and C-terminal regions of LSA-1 from the T9/96 clone reveals high sequence conservation with LSA-1 from NF54. This 200-kDa protein is detected throughout liver schizogony and accumulates in the parasitophorous vacuole space. In our investigation of T and B cell responses to LSA-1, we have focused on both the area of the C-terminal, nonrepetitive "hinge" region and the conserved repetitive region and derived synthetic peptides. These were found to contain major B and T cell determinants. High prevalences and elevated Ab levels to LSA-1, directed primarily, although not exclusively, to the repetitive region, were detected in sera of individuals from one moderately high and two low transmission malaria-endemic areas (prevalences of 97%, 75, and 77%, respectively). In one of these low transmission areas, secretion of the cytokine IFN-gamma, known to inhibit malaria liver stages, and T cell proliferation were detected in PBMC of 22 to 48% and 6 to 20%, respectively, of individuals in response to separate LSA-1 peptides. These results complement the recent finding of conserved CTL epitopes in LSA-1 and support the assertion that immune responses to LS Ag are involved in protection against malaria pre-erythrocytic stages.
Practical Laboratory Andrology (1994)

Abstract This practical manual on sperm analysis presents the diagnostic and therapeutic procedures that are used in andrology laboratories to analyse and assess male infertility. Diagnostic areas include: semen analysis and the biochemical, immunological and microbiological examination of human semen and spermatozoa; computer-aided sperm motility analysis; sperm ultrastructure; and assessment of sperm transport through the female tract and sperm fertilizing ability. The clinical relevance of various diagnostic procedures is also discussed. Therapeutic topics include sperm washing techniques, semen cryopreservation, and insemination procedures. The volume also covers safety in the andrology laboratory, technician training, and quality control. The text is extensively illustrated and will be an invaluable resource to all scientists and technicians who diagnose male infertility. It will also be of interest to researchers working in human gamete biology and reproductive physiology. The detailed methods described in the book are relevant to all hospital, commercial, and university laboratories involved in infertility diagnosis and treatment.
Identification of Multi-Parameter Flame Transfer Function for a Reheat Combustor (2016)

Lean premix technology is widely spread in gas turbine combustion systems, allowing modern power plants to fulfill very stringent emission targets. These systems are however also prone to thermoacoustic instabilities, which can limit the engine operating window. The thermoacoustic analysis of a combustor is thus a key element in its development process. GT24/GT26 reheat combustion system feature a unique technology where fuel is injected into a hot gas stream from a first combustor and auto-ignites in a sequential combustion chamber. Recently, a methodology was successfully developed and validated to analyze the dynamic response of an auto-ignition flame and to extract the Flame Transfer Function using unsteady Large-Eddy Simulations (LES) [GT2015-42622]. The flame was assumed to behave as a Single Input Single Output (SISO) system. The analysis qualitatively highlighted the important role of temperature and equivalence ratio fluctuations, but it was not possible to separate these effects from velocity perturbations. This is the main target of the present work: the flame is treated as a multi-parameter system, and compressible LES are conducted to extract the frequency-dependent flame transfer function. The simulations are forced with uncorrelated broadband signals in order to efficiently calculate the dynamic response over the frequency range of interest. The methodology introduced in this work will help to define stable operation concepts for gas turbines.
The New/Novel Oral Anticoagulants and Their Impact on Patients Being Considered for Shockwave Lithotripsy: The Findings of an International Survey of the Endourological Society (2019)

A large percentage of globally surveyed endourologists do not offer SWL to patients who are taking NOACs. Among those that do offer SWL, there seems to be a absence of consensus on optimal duration of discontinuation, suggesting a need to establish evidence-based guidance to optimize patient outcomes.
ChemInform Abstract: X:Y‐ZH SYSTEMS AS POTENTIAL 1,3‐DIPOLES. 1,5‐ELECTROCYCLIZATION OF IMINES (1983)

Abstract ZH Systems as Potential 1,3‐Dipoles.
Structural Effects in Solvolytic Reactions. II. Nature of the Intermediates Involved in the Solvolysis of Symmetrically Substituted β-Anisylethyl Derivatives (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Effects in Solvolytic Reactions. II. Nature of the Intermediates Involved in the Solvolysis of Symmetrically Substituted β-Anisylethyl DerivativesHerbert C. Brown, Ralph. Bernheimer, C. J. Kim, and Stuart E. ScheppeleCite this: J. Am. Chem. Soc. 1967, 89, 2, 370–378Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/ja00978a036https://doi.org/10.1021/ja00978a036research-articleACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: MOLECULAR REQUIREMENTS OF THE ACTIVE SITES OF THE CHOLINERGIC RECEPTORS. XIX. IZE EVALUATION OF THE MUSCARINIC SUBSITE (1983)

Several ethers and acetylderivatives of deoxamuscarine (I) and its isomers have been synthesized and tested to evaluate the volumetric requirements of the site interacting with the hydroxyl moiety of the agonist (muscarinic subsite). The good potency and affinity for the muscarinic receptor shown by some of these compounds will allow the insertion of an alkylating function in this position of the molecule. Such compounds will be useful to get more information on the topography of the active site and in the isolation of the receptor molecule.