gebhart/patrepeval huggingface dataset:
Alpha-V/Beta-3 and Alpha-V/Beta-5 Integrin Distribution in Neoplastic Kidney (1996)

Integrins are transmembrane glycoproteins that mediate cell-cell and cell-matrix interactions. Altered integrin expression may contribute to tumor progression, invasiveness and metastases. The alpha-V/beta-3 (alpha v beta 3; osteopontin/ vitronectin receptor) has recently been implicated in neovascularization and tumor-induced angiogenesis. alpha v-Subunit also associates with beta 5 to form an alpha v beta 5-complex, another vitronectin receptor. We studied tissue distribution of alpha v beta 3-and alpha v beta 5-integrins, as well as alpha 1- and beta 1-subunits in nephrectomy samples from 7 subjects with localized renal cell carcinoma. Grossly and histologically uninvolved regions ('normal') from the same nephrectomy specimens were used for comparison. Integrin expression was studied with specific monoclonal antibodies and the immunoperoxidase technique. alpha v beta 3 was expressed in the glomerular epithelial cells, Bowman's capsule, vascular endothelium, and weakly in tubular epithelial cells. alpha v beta 5 had a similar distribution except for minimal expression on vascular endothelium. alpha 1-Expression was observed in mesangium and but weakly in Bowman's capsule. beta 1-Expression was seen in glomerular epithelial cells, Bowman's capsule, vascular epithelium and tubular epithelial cells. Unlike in 'normals', neoplastic expression was more heterogeneous alpha v beta 3 was expressed in tumor cells in 4/7 cases, vascular endothelium in 6/6, and in stroma in 4/7. alpha v beta 5 was weakly expressed in tumor cells in 4/5, vascular endothelium in 5/5, and stroma in 4/5 cases. alpha 1-Expression was seen in tumor cells in 3/7, vascular endothelium in 4/7 and in stroma in 7/7 cases. beta 1-Expression was seen in tumor cells in 7/7 cases, vascular endothelium in 7/7, and in stroma in 4/7 cases. This study delineates the pattern of expression of the alpha v beta 3-and alpha v beta 5-integrins in 'normal' and neoplastic human kidney. Variations in alpha v beta 3-and alpha v beta 5-integrin expression may play a role in normal and neoplastic processes of the kidney.
Phonon-assisted transitions from quantum dot excitons to cavity photons (2009)

For a single semiconductor quantum dot embedded in a microcavity, we theoretically and experimentally investigate phonon-assisted transitions between excitons and the cavity mode. Within the framework of the independent boson model we find that such transitions can be very efficient, even for relatively large exciton-cavity detunings of several millielectron volts. Furthermore, we predict a strong detuning asymmetry for the exciton lifetime that vanishes for elevated lattice temperature. Our findings are corroborated by experiment, which turns out to be in good quantitative and qualitative agreement with theory.
Comparison of Citalopram, Perphenazine, and Placebo for the Acute Treatment of Psychosis and Behavioral Disturbances in Hospitalized, Demented Patients (2002)

Citalopram was found to be more efficacious than placebo in the short-term hospital treatment of psychotic symptoms and behavioral disturbances in nondepressed, demented patients.
Effect of cholecystokinin on human cholangiocarcinoma xenografted into nude mice. (1985)

Gastrointestinal polypeptide hormones regulate growth of various normal gastrointestinal tissues as well as certain visceral cancers. Since cholecystokinin (CCK) promotes growth of normal biliary tract, we sought to determine whether CCK affects the growth and metabolism of human cholangiocarcinoma line SLU 132. Twenty-six nude mice with s.c. xenografts of this cancer received either CCK octapeptide (50 micrograms/kg/dose) or 0.9% NaCl solution (saline) twice a day i.p. for 14 days. Tumor volume was calculated from Vernier caliper measurements. At sacrifice on Day 15, tumors were excised, weighed, and examined histologically. DNA, RNA, and protein were measured in the xenografted carcinomas. Because this cholangiocarcinoma produces carcinoembryonic antigen (CEA), we obtained serum at sacrifice for CEA radioimmunoassay and also tumor tissue for CEA immunolabeling with murine anti-CEA monoclonal antibody. Serum CEA levels were 90% higher in the CCK-treated group. Tumor tissue in the CCK-treated group also contained more CEA than did the controls. Mean tumor volume increased significantly in the saline group during the 14-day treatment period, whereas mean tumor volume did not increase significantly in the CCK group. Exogenous high-dose CCK thus appears to increase production and release of CEA from SLU-132; it also appears to retard growth of this tumor line in the nude mouse.
Propagation Protocols for Network-Wide Localization Based on Two-Way Ranging (2010)

In this paper, we study the problem of designing propagation protocols for network-wide localization based on two-way ranging. At the beginning, a network contains a few localized anchor nodes and a large number unlocalized nodes. Unlocalized nodes in the communication range of anchor nodes perform two-way ranging, estimate their positions, and become anchor nodes. The process repeats until all nodes know their positions. We consider three protocols for this propagation process, analyze their convergence speed, and evaluate the communication costs related to the energy consumption. We show that the proposed Optimized Beacon protocol requires much less messages than two other considered protocols while achieving almost the same convergence delay as the Beacon protocol.
Immunogenetic Determinants and Prediction of IDDM in French Schoolchildren (1995)

Islet cell antibodies (ICAs) are predictive markers of the disease in first-degree relatives of patients with insulin-dependent diabetes mellitus (IDDM). The large majority of newly diagnosed cases, however, will develop in children with no family history of diabetes. In France, the risk for development of IDDM up to the age of 20 years is 60 times higher in first-degree relatives than in the general population. The aim of this study was to test whether data collected in the first-degree relatives of IDDM patients could be transferred to children for the prediction of overt diabetes. A large population-based cohort of French school-aged children (n = 13,380; ages 6-17 years) were screened for ICAs, and results were compared with those of 1,185 first-degree relatives of IDDM patients. ICA prevalence rates were significantly different in the two populations (5.5% vs. 1.5%; P < 0.0001), with a significantly higher proportion of high ICA titers in first-degree relatives (37%) than in schoolchildren (14%) (P = 0.0005). ICA titers remained remarkably stable in children over 4 years. Insulin autoantibodies (IAAs) were found in 3.4 and 15.4% of ICA+ children and first-degree relatives, respectively. Susceptibility alleles at the human leukocyte antigen (HLA)-DQB1 locus were observed significantly more frequently in children in whom ICA titers > or = 20 Juvenile Diabetes Foundation units (JDF U) were found on two separate occasions (67%) than in ICA- children (52%) (P = 0.05). Five subjects developed overt diabetes during follow-up. ICA titers of > 20 JDF U were found in all of them on the first sample and at follow-up.(ABSTRACT TRUNCATED AT 250 WORDS)
Adjusting the Chemical Reactivity of Oxygen for Propylene Epoxidation on Silver by Rational Design: The Use of an Oxyanion and Cl (2023)

The development of catalysts for propylene oxide production from direct epoxidation using propylene and oxygen remains a challenge. Compared to ethylene epoxidation, where selectivity on silver catalysts is high, the low selectivity to produce propylene oxide over silver is partially attributed to the lack of electrophilic oxygen under propylene epoxidation reaction conditions. Here, we investigate how to mediate the chemical reactivity of oxygen by theory-inspired experiments for propylene epoxidation. We show how adding electrophilic-O via SO4 oxyanions to the surface of silver increases epoxide selectivity. Moreover, we show how the addition of Cl to the SO4-modified catalyst activates the oxyanion, giving a more than 4-fold increase in selectivity to propylene oxide. Finally, we explore different systems using DFT and draw a picture on how the next catalyst/co-catalyst systems should be tuned to design a catalyst with high selectivity for direct propylene oxidation.
A parallel spectral model for atmospheric transport processes (1996)

The paper describes a parallel implementation of a grand challenge problem: global atmospheric modeling. The novel contributions of our work include (1) a detailed investigation of opportunities for parallelism in atmospheric global modeling based on spectral solution methods, (2) the experimental evaluation of overheads arising from load imbalances and data movement for alternative parallelization methods, and (3) the development of a parallel code that can be monitored and steered interactively based on output data visualizations and animations of program functionality or performance. Code parallelization takes advantage of the relative independence of computations at different levels in the earth's atmosphere, resulting in parallelism of up to 40 processors, each independently performing computations for different atmospheric levels and requiring few communications between different levels across model time steps. Next, additional parallelism is attained within each level by taking advantage of the natural parallelism offered by the spectral computations being performed (e.g. taking advantage of independently computable terms in equations). Performance measurements are performed on a 64-node KSR2 supercomputer. However, the parallel code has been ported to several shared memory parallel machines, including SGI multiprocessors, and has also been ported to distributed memory platforms like the IBM SP-2.
Bayesian Inversion Of Multi-Mode Nems Mass Spectrometry Signal (2013)

Publication in the conference proceedings of EUSIPCO, Marrakech, Morocco, 2013
Adaptive Modified Method of Characteristics to Solve the One‐Dimensional Solute Transport Equation (1995)

Abstract Simulation of advection‐dominated solute transport in a porous medium is complicated due to the inherent problems of numerical dispersion and oscillation. We propose an adaptive modified method of characteristics (AMMOC) to simulate one‐dimensional, advection‐dominated solute transport problems, which incorporates the advantage of a self‐adaptive spatial grid system with the computational power of the modified method of characteristics (MMOC) to deal with numerical dispersion and oscillation. The numerical simulations, including a pure advection problem, show that the AMMOC is free of oscillation, approximately global mass conservative, and exhibits insignificant numerical dispersion. Related to this method, three interpolation schemes to obtain the concentration of the fictitious particle at the previous time step were also evaluated. Our simulations show that the AMMOC, based on a clipped quadratic interpolation scheme, provides the most accurate results.
Taxane: eine ungewöhnliche Naturstoffklasse (1989)

Abstract „Synthese im Blickpunkt”︁ will zur Beschäftigung mit neuen synthetischen Verfahren oder besonders eleganten und wichtigen Synthesen aus der aktuellen chemischen Literatur anregen ‐ ohne Anspruch auf Vollständigkeit. Die Rubrik wird 1989 betreut von Dr. D. Schinzer, Universität Hannover.
Association Between Plasma Total Homocysteine and Parental History of Cardiovascular Disease in Children With Familial Hypercholesterolemia (1997)

These findings suggest that a moderately elevated tHcy level may partly account for the contribution of the family history to risk of CVD in FH. Dietary recommendations for FH should include nutrients that affect homocysteine metabolism.
Nickelspezies: Analyse und toxische Effekte (2013)

Dieser Review-Artikel gibt einen Überblick über die Analyse anorganischer Nickelspezies und ihre toxischen Effekte. Auf der Grundlage des eingesetzten analytischen Verfahrens werden anorganische Nickelspezies üblicherweise in lösliche, sulfidische, metallische und oxidische Fraktionen eingeteilt. Nur in wenigen Arbeiten wurde versucht, die verschiedenen Nickelverbindungen in den einzelnen Fraktionen zu charakterisieren. Diese allgemeine Klassifizierung in vier Nickelspezies-Gruppen wird in toxikologischen Untersuchungen, die sich mit Nickelpartikeln in der Arbeitsplatzluft befassen, häufig angewendet. Im Vergleich zur Allgemeinbevölkerung besteht bei berufsbedingt exponierten Personen in der Nickel verarbeitenden oder verwendenden Industrie ein höheres Risiko für Krebs der Atemwege aufgrund der Inhalation von Nickel am Arbeitsplatz. Ein hohes Krebsrisiko ist mit weniger löslichen oxidischen und insbesondere sulfidischen Nickelspezies im Staub von Raffinerien verbunden. Im Gegensatz dazu ist bei der Allgemeinbevölkerung der gesundheitsschädlichste Effekt im Zusammenhang mit einer Exposition gegenüber Nickel ein allergisches Kontaktekzem infolge längeren Hautkontakts mit Nickel. Die Prozesse der Resorption von Nickelspezies und die molekularen Mechanismen der Nickeltoxizität werden kurz dargestellt.
Fucans, sulfated polysaccharides extracted from brown seaweeds, inhibit vascular smooth muscle cell proliferation. I. Comparison with heparin for antiproliferative activity, binding and internalization. (1997)

Smooth muscle cell (SMC) proliferation is inhibited both in vivo and in vitro by heparin. However, the precise mechanisms of action are still not understood. The analogy between two sulfated polysaccharides, heparin and fucan, has led us to compare in detail their effects on SMC growth. We have prepared and characterized a 19 kDa fucan fraction from brown seaweed, Ascophyllum nodosum. Fucan affects the growth of SMCs in a time- and dose-dependent, reversible and non-toxic fashion. As determined by cell counting, [3H]thymidine incorporation, and microcytofluorimetry analysis, heparin was less active than fucan in inhibiting SMC growth. Fucan and heparin act by preferential blocking of G0/G1, thus decreasing the G0/S transition. Binding experiments with [125I]fucan indicated saturable, unlabeled-fucan displaceable binding sites with an apparent Kd of 30 nM. Moreover, displacement experiments performed with various polysaccharides revealed that antiproliferative compounds interacted with these membrane sites, but non-antiproliferative polysaccharides (dextran, chondroitin sulfate) did not, providing evidence of a correlation between binding to SMCs and their antiproliferative activity. When cells were exposed at 37 degrees C to a fluorescent 5-([4,6-dichlorotriazin-2-yl]-amino)fluorescein (DTAF)-fucan, internalization occurred and punctate vesicles were observed which accumulated rapidly in the perinuclear region as previously reported for heparin. Nuclear preparations (membranes + contents) of cultured SMCs previously incubated with radiolabeled heparin or fucan indicated the presence of radioactivity, suggesting an antiproliferative action of both polysaccharides at the nuclear level. Collectively, these observations indicated that fucan and heparin share some similar mechanisms of action, such as SMC growth inhibition, binding, and internalization. In the accompanying paper (Logeart et al., Eur. J. Cell Biol. 74, 1997, this issue), we describe the effect of fucans of different molecular weights and conclude that there is no direct link between polysaccharide degradation and the antiproliferative effect on SMCs.
Myasthenia Gravis and Associated Autoimmune Diseases in Children (2000)

Myasthenia gravis has been associated with other autoimmune disorders. We report two children with myasthenia gravis and another autoimmune disease: an 18-month-old boy with ocular myasthenia gravis and Hashimoto's disease and a 14-year-old girl presenting with autoimmune polymyositis, then generalized myasthenia gravis 2 years later. The rare combinations of myasthenia gravis and Hashimoto's disease or polymyositis in children are discussed, and we also briefly review myasthenia gravis and other associated autoimmune diseases in children.
An Accelerometer-Based Earpiece to Monitor and Quantify Physical Activity (2009)

The subjects tolerated the earpiece well and were comfortable wearing it. The PASE can therefore be used to reliably monitor free-living physical activity and its associated energy expenditure.
Novel rhenium(iii, iv, and v) tetradentate N2O2 Schiff base mononuclear and dinuclear complexes (2013)

Reaction of (Bu4N)[ReOCl4] with the tetradentate Schiff base ligand α,α'-[(1,1-dimethylethylene)dinitrilo]di-o-cresol (sal2ibnH2) yields cis-[Re(V)OCl(sal2ibn)], which quickly forms trans-[μ-O(Re(V)O(sal2ibn))2] in solution. The dinuclear complex can also be isolated by the addition of base (Et3N) to the reaction mixture. Conversely, the mononuclear complex can be trapped as cis-[Re(V)O(NCS)(sal2ibn)] by addition of (Bu4N)SCN to the reaction mixture. Reduction of cis-[Re(V)O(NCS)sal2ibn] with triphenylphosphine gives the rare trans-[Re(III)(NCS)(PPh3)(sal2ibn)] and unique μ-oxo Re(IV) dimer trans-[μ-O(Re(IV)(NCS)(sal2ibn))2]. All of the complexes were characterized by (1)H and (13)C NMR, FT-IR spectroscopy, electrospray ionization mass spectrometry (ESI-MS), cyclic voltammetry and single crystal X-ray diffraction.
The blood‐brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport (2016)

We purposed to clarify the contribution of fatty acid transport protein 1 (FATP1/SLC 27A1) to the supply of docosahexaenoic acid (DHA) to the brain across the blood-brain barrier in this study. Transport experiments showed that the uptake rate of [<sup>14</sup> C]-DHA in human FATP1-expressing HEK293 cells was significantly greater than that in empty vector-transfected (mock) HEK293 cells. The steady-state intracellular DHA concentration was nearly 2-fold smaller in FATP1-expressing than in mock cells, suggesting that FATP1 works as not only an influx, but also an efflux transporter for DHA. [<sup>14</sup> C]-DHA uptake by a human cerebral microvascular endothelial cell line (hCMEC/D3) increased in a time-dependent manner, and was inhibited by unlabeled DHA and a known FATP1 substrate, oleic acid. Knock-down of FATP1 in hCMEC/D3 cells with specific siRNA showed that FATP1-mediated uptake accounts for 59.2-73.0% of total [<sup>14</sup> C]-DHA uptake by the cells. Insulin treatment for 30 min induced translocation of FATP1 protein to the plasma membrane in hCMEC/D3 cells and enhanced [<sup>14</sup> C]-DHA uptake. Immunohistochemical analysis of mouse brain sections showed that FATP1 protein is preferentially localized at the basal membrane of brain microvessel endothelial cells. We found that two neuroprotective substances, taurine and biotin, in addition to DHA, undergo FATP1-mediated efflux. Overall, our results suggest that FATP1 localized at the basal membrane of brain microvessels contributes to the transport of DHA, taurine and biotin into the brain, and insulin rapidly increases DHA supply to the brain by promoting translocation of FATP1 to the membrane. Read the Editorial Comment for this article on page 324.
Thermal transport through ac-driven transparent Josephson weak links (2014)

We discuss how phase coherence manifests in the heat transport through superconducting single and multichannel Josephson junctions in time-dependent situations. We consider the heat current driven through the junction by a temperature difference in dc voltage and ac phase biased situations. At low bias, the electromagnetic driving mainly modifies the form of the coherent resonance that transports a large part of the heat current, rather than simply dissipating energy in the junction. We find a description for the heat current in terms of quasiparticle $n$-photon absorption and emission rates, and discuss analytical and numerical results concerning them. In addition to the ensemble average heat transport, we describe also its fluctuations.
Chapter 7. Recent Advances in the Discovery of GPR119 Agonists (2012)

The increased worldwide prevalence of diabetes mellitus (DM) in recent decades has been accompanied by an increase in the number of available pharmacologic therapies used to treat the disease. Differentiation of the available drugs is therefore an important factor for managing the disease effectivel...
STM Tip Induced Phase Transition of Copper Tetracyanoquinodimethane (CuTCNQ) (1995)

Abstract We have demonstrated a field-induced, charge-transfer reaction driven by the electric field at the STM tip when the field generated by the STM exceeds the switching threshold of CuTCNQ charge transfer complex. We discuss the mechanism of this nanoscopic phenomenon in comparison with macroscopic observations.
Reproducing a Roman maritime structure with Vitruvian pozzolanic concrete (2006)

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Cotton powder for infrared transmission measurements (1950)

Cotto n cut in a Wiley mill to pass a 20-mesh scr ee n was ground in a vibrator y ball mill similar to one t hat has been used in German y and H olland. Con tamination of the cotton was practically elimin ated by using a chromium-plated hardened steel jar and chl'omium all oy balls. The jar holder is held by a slip rin g instead of being bolted in place. The jar and holder automatically rotate slowly on t h eir axis, and t his motion co unteracts t he ten dency of t he cotton in t he jar to settle and grind nonuniforml}'. The jar is cooled by blowing air over it and becomes bare ly warm to t he to uch.
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours (1982)

The activities of two lipogenic enzymes, acetyl-CoA carboxylase and fatty acid synthase, were determined in two transplantable mammary adenocarcinomas (13762 and R3230AC) carried by non-pregnant, pregnant and lactating rats, and in mammary tissue of control animals (non-tumour-carrying) of comparable physiological states. During mammary-gland differentiation of control or tumour-carrying animals, the activities of acetyl-CoA carboxylase and fatty acid synthase in the lactating gland increased by about 40--50-fold over the values found in non-pregnant animals. On the other hand, in tumours carried by lactating dams there were only modest increases (1.5--2-fold) in acetyl-CoA carboxylase and fatty acid synthase compared with the neoplasms carried by non-pregnant animals. On the basis of the Km values for different substrates and immunodiffusion and immunotitration data, the fatty acid synthase of neoplastic tissues appeared to be indistinguishable from the control mammary-gland enzyme. However, a comparison of the immunotitration and immunodiffusion experiments indicated that the mammary-gland acetyl-CoA carboxylase might differ from the enzyme present in mammary neoplasms.