gebhart/patrepeval huggingface dataset:
Synthesis of degradable crosslinked polymers based on 1,5-dioxepan-2-one and crosslinker of bis-?-caprolactone type (1997)

Poly(lactones) may be crosslinked by ring-opening polymerization of the corresponding cyclic esters in the presence of tetrafunctional bis(ϵ-caprolactone). The homopolymer of 1.5-dioxepan-2-one (DXO) has poor mechanical properties but also some very good properties, such as biocompatibility and degradability. Crosslinking of degradable polymer based on the poly(ether-ester) DXO was performed with crosslinkers having the same reactivity as the monomer. 2,2-Bis(ϵ-caprolactone-4-yl)propane (BCP) and bis(ϵ-caprolactone-4-yl) (BCY) with tetrafunctionalities were synthesized from the corresponding diols and then used as comonomers during the polymerization of DXO. The comonomers showed the same reactivity to the initiator, stanneous 2-ethylhexanoic acid, as DXO and perfectly random crosslinked films were obtained. The crosslinked films showed a high degree of swelling already at 2–3 mol % BCP or BCY. The BCP crosslinker was somewhat less soluble in DXO at lower temperatures, but all BCP was soluble at 180°C. These polymeric films were elastic with no crystallinity and the Tg values increased from −39°C for pure DXO to −35°C for BCP crosslinked films and −21°C for BCY crosslinked ones. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 1635–1649, 1997
Durability Of Field Concrete Made Of Portland Cement And Supplementary Cementitious Materials Under Several European Exposure Conditions (2008)

Deterioration of cementitious materials by sulfate ions is a concern for concrete in contact with ground water (and in a lesser extent sea water) in many parts of Europe, and is an important issue for underground construction identified as a major area for progress in the construction industry. Sulfate resistance relates closely to testing and standardization and therefore to prescriptive approaches. The lack of feed back oil the durability of structures made of blended cements makes it difficult to fit these new concretes with existing test methods and performance criteria. This paper concerns the microstructural Study of field samples and structures made of blended concretes available across Europe. This concerns several materials exposed to various climate regimes, ranging from Southern to Northern Europe (Spain, Germany, United Kingdom, Denmark and Norway). Complementary techniques Such as SEM, micro-XR-F, XR-D and PIXE are used to evaluate the microstructural performance and stability of the phase assemblage of those blended concretes in the case of sulflate (and chloride in some instances) ingress, compare to pure Portland concrete.
Economics of assisted reproduction: Access to fertility treatments and valuing live births in economic terms (2009)

The intricate relationship between economic conditions and natural fertility is known to influence both the timing and number of children conceived. For infertile couples, the relationship between economics and fertility is more explicit because of the necessity for many couples to pay for treatment to achieve childbirth. Consequently, affordability often dictates whether or not someone is able to undergo treatment, as well as the types of treatments available. Economics can also be used to describe treatment outcomes achieved through the use of fertility treatments. While gynaecologists and couples speak of outcomes in terms of live births, economists are often inclined to view live births and their influence on society in economic terms. In this review we consider two distinct elements of economics and assisted reproduction. Firstly, how economics (i.e. affordability) can influence demand for, and access to, fertility treatments, and secondly, how methods for valuing live births achieved using assisted reproductive technologies in economic terms can highlight the importance of these children in the context of ageing populations. This review will attempt to illustrate that the economic benefits attributed to children conceived through fertility treatments are much greater than health costs required for conception and should be considered in future reimbursement decisions in this therapy area.
The impact of junction angle on tunnel FETs (2011)

We derive an analytical model based on circular tunnel paths along the electric field to describe the behavior of a tunnel FET with a junction angle at the source. The model is compared with simulation results and qualitative agreement is observed. We further demonstrate that a small junction angle prevents TFET performance degradation resulting from a high-k spacer. Finally we optimize the junction angle with an encroaching source structure, studying the dependence on oxide thickness and semiconductor material.
Energy-Aware Cooperative Computation in Mobile Devices (2016)

New data intensive applications, which are continuously emerging in daily routines of mobile devices, significantly increase the demand for data, and pose a challenge for current wireless networks due to scarce resources. Although bandwidth is traditionally considered as the primary scarce resource in wireless networks, the developments in communication theory shifts the focus from bandwidth to other scarce resources including processing power and energy. Especially, in device-to-device networks, where data rates are increasing rapidly, processing power and energy are becoming the primary bottlenecks of the network. Thus, it is crucial to develop new networking mechanisms by taking into account the processing power and energy as bottlenecks. In this paper, we develop an energy-aware cooperative computation framework for mobile devices. In this setup, a group of cooperative mobile devices, within proximity of each other, (i) use their cellular or Wi-Fi (802.11) links as their primary networking interfaces, and (ii) exploit their device-to-device connections (e.g., Wi-Fi Direct) to overcome processing power and energy bottlenecks. We evaluate our energy-aware cooperative computation framework on a testbed consisting of smartphones and tablets, and we show that it brings significant performance benefits.
Focal adhesion protein expression in human diffuse large B‐cell lymphoma (2014)

FAK expression is an independent prognostic factor in DLBCL. Our results suggest that the addition of FAK immunostaining to the current immunohistochemical algorithms may facilitate risk stratification of DLBCL patients.
Microgravity Two-Phase Flow Experiment and Test Results (1991)

A two-phase flow system was tested in the NASA KC-135 reduced gravity test facility. Its innovative flow configuration results in an unusual ease of control and significantly reduced power and heat rejection requirements, while permitting flow regimes, pressure drops, and boiling and condensing heat transfer to be examined. Numerous design features were incorporated that minimize the impact of the KC-135 environment on system condition. Among other results, flight testing indicates no significant effect of gravity on pressure drop for the conditions examined, and that many conditions can be examined definitively only in the long-term reduced gravity afforded by a space experiment.
Engineering of Complex Order and the Macroscopic Deformation of Liquid Crystal Polymer Networks (2012)

Auf- oder abwärts: Komplex strukturierte freistehende Polymerfilme mit einer dreidimensionalen molekularen Ordnung wurden durch Photoausrichtung polymerisierbarer Flüssigkristalle hergestellt. Die gebildeten Filme verformen sich beim Erhitzen zu Kegel- und Sattelformen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations (1994)

Synthetic procedures have been developed which lead to the 2-aza congeners 3 and several related N-oxides 4. The analogues 3 exhibited a wide range of in vitro cytotoxicity against L1210 leukemia, the human colon adenocarcinoma cell line LoVo, and the doxorubicin resistant LoVo/DX cell line. Selected analogues of 3 showed significant P388 antileukemic activity in mice with 3c exhibiting high activity. This activity was also retained in the related N-oxide 4a. These heterocyclic bioisosteric models are representative of the first anthracene-9,10-diones which display antileukemic activity comparable to mitoxantrone.
Whey protein concentrates and isolates: Processing and functional properties (1993)

Substantial progress has been made in understanding the basic chemical and structural properties of the principal whey proteins, that is, beta-lactoglobulin (beta-Lg), alpha-lactalbumin (alpha-La), bovine serum albumin (BSA), and immunoglobulin (Ig). This knowledge has been acquired in terms of: (1) procedures for isolation, purification, and characterization of the individual whey proteins in buffer solutions; and (2) whey fractionation technologies for manufacturing whey protein concentrates (WPC) with improved chemical and functional properties in food systems. This article is a critical review of selected publications related to (1) whey fractionation technology for manufacturing WPC and WPI; (2) fundamental properties of whey proteins; and (3) factors that affect protein functionality, that is, composition, protein structure, and processing.
Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides (2006)

We have previously provided evidence suggesting that phosphatidic acid, possibly derived from the hydrolysis of phosphatidylcholine by phospholipase D (PLD), is involved in platelet-derived growth factor (PDGF)-mediated increases in extracellular signal-regulated kinase (ERK) activity and DNA synthesis in rat hepatic stellate cells (HSC), the primary fibrogenic cells of the liver. A recent study has shown the presence of P2Y nucleotide receptors on HSC that are coupled to contraction and synthesis of the matrix component, alpha1-procollagen, leading to the suggestion that they may represent a new therapeutic target in the treatment of liver fibrosis. However, although extracellular nucleotides have been shown to stimulate both PLD and ERK, and to elicit proliferation of fibrogenic cells outside the liver, their effect on these parameters in HSC have not yet been investigated. PLD activity was determined by [3H]choline release and [3H]phosphatidylbutanol production, ERK activity by Western blotting, and DNA synthesis by [3H]thymidine incorporation. We report here, for the first time in HSC, that extracellular nucleotides stimulate PLD activity and a sustained activation of ERK. However, in contrast to PDGF, nucleotides had negligible effects on DNA synthesis. Moreover, the effects of PDGF and nucleotides on PLD and ERK were not additive, suggesting activation of the same PLD isoform and pool of ERK. The data demonstrate that nucleotide-stimulated PLD and ERK activities are not coupled to DNA synthesis in HSC. Instead, these responses may be linked to other phenotypic changes associated with activated HSC such as increases in contraction, motility, or extracellular matrix deposition.
Integration of Transcriptional and Posttranslational Regulation in a Glucose Signal Transduction Pathway in Saccharomyces cerevisiae (2006)

Expression of the HXT genes encoding glucose transporters in the budding yeast Saccharomyces cerevisiae is regulated by two interconnected glucose-signaling pathways: the Snf3/Rgt2-Rgt1 glucose induction pathway and the Snf1-Mig1 glucose repression pathway. The Snf3 and Rgt2 glucose sensors in the membrane generate a signal in the presence of glucose that inhibits the functions of Std1 and Mth1, paralogous proteins that regulate the function of the Rgt1 transcription factor, which binds to the HXT promoters. It is well established that glucose induces degradation of Mth1, but the fate of its paralogue Std1 has been less clear. We present evidence that glucose-induced degradation of Std1 via the SCF(Grr1) ubiquitin-protein ligase and the 26S proteasome is obscured by feedback regulation of STD1 expression. Disappearance of Std1 in response to glucose is accelerated when glucose induction of STD1 expression due to feedback regulation by Rgt1 is prevented. The consequence of relieving feedback regulation of STD1 expression is that reestablishment of repression of HXT1 expression upon removal of glucose is delayed. In contrast, degradation of Mth1 is reinforced by glucose repression of MTH1 expression: disappearance of Mth1 is slowed when glucose repression of MTH1 expression is prevented, and this results in a delay in induction of HXT3 expression in response to glucose. Thus, the cellular levels of Std1 and Mth1, and, as a consequence, the kinetics of induction and repression of HXT gene expression, are closely regulated by interwoven transcriptional and posttranslational controls mediated by two different glucose-sensing pathways.
New options and controversies in the management of chemotherapy-induced nausea and vomiting (2017)

Newer therapeutic options for the management of CINV are equivalent to standard-of-care regimens in terms of efficacy and toxicity. While the NK<sub>1</sub> receptor antagonist rolapitant and a product combining palonosetron and netupitant have potential advantages over standard therapy in terms of convenience or pharmacologic properties, their relatively high costs must be considered.
Cloning and functional expression of a novel glucuronyltransferase involved in the biosynthesis of the carbohydrate epitope HNK-1 (1997)

The HNK-1 carbohydrate epitope is characteristically expressed on a series of cell adhesion molecules and also on some glycolipids in the nervous system over a wide range of species from insect to mammal. The HNK-1 epitope is involved in cell-cell and/or cell-substrate interaction and recognition during the development of the nervous system. In this study, we isolated a novel glucuronyltransferase from rat brain, which is a key enzyme of the biosynthesis of the HNK-1 epitope on glycoproteins. Based on the partial amino acid sequences, we isolated cDNA encoding the glucuronyltransferase. The primary structure deduced from the cDNA sequence predicted a type II transmembrane protein with 347 amino acids and had no detectable similarity with any other proteins of known functions, including glucuronyltransferases of the liver and olfactory epithelium. Expression of a soluble recombinant form of the enzyme in COS-1 cells produced an active glucuronyltransferase. The selective expression of the glucuronyltransferase gene in the nervous system was consistent with the almost exclusive localization of the HNK-1 epitope in the nervous system. Transfection of the glucuronyltransferase cDNA into COS-1 cells induced not only expression of the HNK-1 epitope on the cell surface but also marked morphological changes of the cells, suggesting that the HNK-1 epitope associates with the cell-substratum interaction.
Unwed motherhood, adoption reunion and stigmatized social identities (2019)

Data gathered from semi-structured interviews with 33 reunited birth mothers show they had been stigmatized for their unwed motherhood and hid this identity to protect self from social censure. The public exposure created by reunion contact with their adult placed children required new ways to manage this stigma trait. The women engaged in a process of identity talk supported by their understanding of altered perceptions of female sexuality and a “no choice” discourse that drew upon historical changes in the social position of unwed mothers. This identity talk increased their self-efficacy by providing stronger control over their presentation of self.
Hydrogen-induced Unzipping of Single-Walled Carbon Nanotubes (2002)

The chemisorption of atomic hydrogen on the single-walled armchair carbon nanotube is studied with ab initio calculations. A single H atom is found to be chemisorbed on both the inside and outside wall of the nanotube. The binding energy of H adsorption at the exterior of the nanotube is much greater than that at the interior of the nanotube. For the first time, we predict that two rows of H atoms chemisorbed on selective sites exterior to the nanotube can break the nearest-neighbor C-C bond of the nanotube through the concerted formation of C-H bonds, leading to the unzipping of the nanotube wall. We provide insights into the underlying electronic structure responsible for the H-induced unzipping of the nanotube, lending strong support to the recent experimental observations for the coalescence of single-walled nanotubes in the presence of atomic hydrogen. Interestingly, H atoms chemisorbed inside the nanotube do not lead to the breaking of the C-C bonds.
Tribological Behavior of Surfaces Obtained by Turning in Sintered Self-Lubricating Composites (2020)

This work presents a study on the tribological behavior of surfaces obtained by turning in sintered self-lubricating composites. Turned surfaces were obtained at constant cutting speed (vc = 100 m/min), feed (f = 0.2 mm), and depth of cut (ap = 1 mm). The tested composites have solid lubricants (graphite and hexagonal boron nitride, h-BN) mixed in an Fe-C-Ni-Si matrix manufactured by single pressing (SP) and double pressing (DP). The turned and sintered surfaces were analyzed by scanning electron microscopy (SEM) and quantified by the roughness parameters Sq (root mean square height), Ssk (skewness), Sbi (bearing surface index), and Str (texture aspect ratio). The tribological tests were performed on turned and sintered surfaces with a cylinder–cylinder configuration. Raman spectroscopy and SEM were used to characterize the wear scars. Machining reduced the Sq parameter by 35 and 45% for the SP and DP materials, respectively, and the Ssk by 100%. The turned surfaces did not present friction coefficient values within the lubricity limit (µ < 0.2). The friction coefficient and the wear rate of the turned surfaces were around 320 and 40% higher, respectively, than those of the sintered surfaces.
[3+2] cycloadditions with 1,2-difluorovinylphenylsulfone (1997)

[3+2] Cycloaddition reactions of (E) and (Z)-1,2-difluorovinylphenylsulfones with diphenylnitrone, ethyl- and mesitylnitrile oxides and diphenylnitrile imine have been studied. The behaviour of these new dipolarophiles has been compared to that of the related phenylvinylsulfone and 1-fluorovinylphenylsulfone.
Role of screw dislocations in electrolytic crystal growth (1977)

The theory of form and interstep distance of spirals and the growth rate of crystals under spiral growth conditions are discussed and illustrated for the electrodeposition of silver. The overvoltage dependence of the slopes of pyramids can be used for the evaluation of the rate of propagation and the specific edge energy of the spiral steps, the latter being also accessible from experimental current against overvoltage curves. The coincidence of these values with values obtained from other experiments (two-dimensional nucleation) is a good proof of the validity of the theory of spiral growth.
CHAMP+ Thailand: Pilot Randomized Control Trial of a Family-Based Psychosocial Intervention for Perinatally HIV-Infected Early Adolescents (2019)

Within Asia, HIV prevalence is highest in Thailand, including thousands of children and adolescents. Care for children born with HIV [perinatal transmission of HIV (PHIV)] will need to focus on adolescents for the foreseeable future. Thai PHIV adolescents experience significant mental health and psychosocial challenges, including treatment adherence. Yet, few, if any, comprehensive interventions for them exist. CHAMP+, an evidence-based intervention adapted for Thailand, was evaluated with a pilot randomized control trial at four HIV clinics. Eighty-eight dyads of 9- to 14-year-old PHIV young adolescents/caregivers were randomized to CHAMP+ or standard of care (SOC). Eleven cartoon-based sessions were delivered over 6 months. Participants completed baseline, 6-month (postintervention), and 9-month surveys, measuring youth outcomes (e.g., mental health and adherence), contextual factors (e.g., demographics and caregiver factors), and self- and social-regulation factors (e.g., HIV knowledge and youth-caregiver communication). Multi-level modeling to account for clustering within individuals was used to assess longitudinal changes within and between groups. All families randomized to CHAMP+ completed the intervention. Although the study was not statistically powered to detect differences in treatment effects, the CHAMP+ group significantly improved at 6 months in youth mental health and adherence, HIV knowledge, youth-caregiver communication, internalized stigma, and HIV-related social support, with most improvements sustained at 9 months and significantly better improvements than the SOC group on a number of outcomes. High levels of baseline viral suppression highlight the importance of reaching these young PHIV adolescents at a period of lower risk before adherence and other challenges emerge. Designed to be delivered with limited cost/resources, CHAMP+ Thailand holds scale-up potential.
[Chronic inflammatory demyelinating polyneuropathy followed by systemic lupus erythematosus and Sjögren syndrome: a case report]. (2006)

We report a 60-year-old man with chronic inflammatory demyelinating polyneuropathy (CIDP) accompanying systemic lupus erythematosus (SLE) and Sjögren syndrome (SS). He was admitted to our hospital because of progressive weakness and dysesthesia in the distal parts of the bilateral upper and lower extremities. We diagnosed the illness as CIDP and treated him with steroids, plasma filtration and high-dose intravenous immunoglobulin therapy (IvIg). Consequently, his symptoms improved gradually and he was discharged. However, 2 years after the first admission, he experienced dyspnea on effort and chest X-ray demonstrated right pleural effusion. Consequently, he gradually developed gait disturbance, loss of taste, and severe dysesthesia in his lower limbs. Therefore, he was admitted again. On neurological examination, mild weakness was detected in all limbs distally. Deep tendon reflexes were absent. The sensation of position and vibration was diminished in the fingers and toes. He could not walk by himself and demonstrated an ataxic gait with a wide base. Examination of cranial nerves demonstrated no abnormalities, except for loss of taste. Serological examination demonstrated positive auto-antibodies including antinuclear, anti-DNA, and anti-SS-A antibodies. Urinalyses showed albuminuria and microscopic hematuria. Cerebrospinal fluid (CSF) was clear and colorless, containing 3 mononuclear cells per cubic mm, with a protein of 275 mg/dl. Magnetic resonance images (MRIs) of the brain and entire spine were normal. Neurophysiological studies demonstrated an absence of sensory nerve action potentials in the right arm and markedly slow conduction velocities, conduction block in the ulnar forearm segment and absence of F waves in all limbs. The renal biopsy revealed lupus nephritis. The lip biopsy demonstrated chronic sialoadenitis consistent with SS, altough patient did not show symptoms of arthritis or vasculitis. It is well known that mononeuritis multiplex and acute demyelinating polyneuropathy accompany SLE. However there are few reports that describe the occurrence of CIDP in patients with SLE, and the association of "CIDP-like" neuropathy in patients with SS. Our case suggests that the autoimmune disease associated with SLE and SS may induce "CIDP-like" inflammatory demyelinating polyneuropathy.