gebhart/patrepeval huggingface dataset:
[Platelet factor 4 acts as both inhibitor and protector of hematopoietic precursor cells: possible mechanism of action]. (1995)

We have previously shown that platelet factor 4 (PF 4) is a potent inhibitor of megakaryocytopoiesis and that it may protect stem cells from 5-fluorouracil (5-FU) cytotoxicity. In the present work, the effects of human PF 4 on megakaryocyte (MK) growth from human CD34+ cord blood (CB) cells were studied in comparison with transforming growth factor beta 1 (TGF-beta 1). Development of MK from CD34+ cells in both plasma clot culture and liquid culture was significantly inhibited by PF 4 (5 micrograms/ml) and TGF beta 1 (1 ng/ml). Inhibition of cell growth by PF 4 was reversible judging from the fact that the CD34+ cells preincubated with PF 4 could regenerate colonies after washing and replating into the cultures. By contrast, TGF-beta 1 pretreated CD34+ cells gave rise to few colonies following replating. Moreover, incubation of CD34+ cells with PF 4 in liquid culture caused an increase in the number of both stem cell factor (SCF)-binding cells and CD34 antigen-bearing cells, and exhibited greater capacity to form MK colonies than control after the treatment of 5-FU. In vivo in mice, twice injections of PF 4 at 40 micrograms/kg with an interval of 6 h followed by one injection of 5-FU at 150 mg/kg resulted in a significant increase in the number of colony-forming cells with high proliferative potential (HPP-CFC) and colony-forming unit-megakaryocyte (CFU-MK) in bone marrow. In exponentially growing human erythroleukemia cells (HEL), the addition of PF 4 prolonged cell cycle progression and therefore resulted in an increased cell population in S phase, as determined by flow cytometric analysis. Different from PF 4, TGF-beta 1 blocked more cells in G 1 phase. These results demonstrate that PF 4 and TFG-beta 1 inhibit MK development from CD34+ CB cells by different mechanisms and suggest that PF 4, unlike TGF-beta 1, exerts its inhibitory effect on cell growth in a reversible and S phasespecific manner by which it protects stem cells and MK progenitor cells from 5-FU cytotoxicity.
A Survey on Privacy Frameworks for RFID Authentication (2012)

Due to rapid growth of RFID system applications, the security and privacy problems become more and more important to guarantee the validity of RFID systems. Without introducing proper privacy protection mechanisms, widespread deployment of RFID could raise privacy concerns to both companies and individuals. As a fundamental issue for the design and analysis of secure RFID systems, some formal RFID privacy frameworks were proposed in recent years to give the principles for evaluating the security and privacy in RFID system. However, readers can be confused with so many proposed frameworks. In this paper, we make a comparative and survey study on the proposed RFID privacy frameworks. We mainly divide the existing models into three categories, the four-oracle framework, eight-oracle framework and Universal Composability framework. We give a brief review on the existing models and describe their abilities to model the adversarial behavior in RFID systems. We then analyze relations among those existing RFID privacy models and make some comparisons among their properties.
UV absorbing zwitterionic pyridinium-tetrazolate: exceptional transparency/optical nonlinearity trade-off (2010)

We present relevant results dealing with the transparency/optical nonlinearity trade-off in high-frequency electro-optic applications. The very simple, stable and high optical gap chromophore, the zwitterion 1-methyl-4-(tetrazol-5-ate)pyridinium, represents the best transparency/optical nonlinearity trade-off so far described in the literature. We rationalize this remarkable performance in the framework of the Bond Length Alternation theory by means of a multidisciplinary approach including: single crystal X-ray structure, Electric Field Induced Second-Harmonic Generation, solvatochromism, electrochemistry and thermal analyses.
Invited Lecture - Material formation through self-organisation: understand to innovate synthesis (2013)

status: Published
MonoGraspNet: 6-DoF Grasping with a Single RGB Image (2022)

6-DoF robotic grasping is a long-lasting but unsolved problem. Recent methods utilize strong 3D networks to extract geometric grasping representations from depth sensors, demonstrating superior accuracy on common objects but perform unsatisfactorily on photometrically challenging objects, e.g., objects in transparent or reflective materials. The bottleneck lies in that the surface of these objects can not reflect back accurate depth due to the absorption or refraction of light. In this paper, in contrast to exploiting the inaccurate depth data, we propose the first RGB-only 6-DoF grasping pipeline called MonoGraspNet that utilizes stable 2D features to simultaneously handle arbitrary object grasping and overcome the problems induced by photometrically challenging objects. MonoGraspNet leverages keypoint heatmap and normal map to recover the 6-DoF grasping poses represented by our novel representation parameterized with 2D keypoints with corresponding depth, grasping direction, grasping width, and angle. Extensive experiments in real scenes demonstrate that our method can achieve competitive results in grasping common objects and surpass the depth-based competitor by a large margin in grasping photometrically challenging objects. To further stimulate robotic manipulation research, we additionally annotate and open-source a multi-view and multi-scene real-world grasping dataset, containing 120 objects of mixed photometric complexity with 20M accurate grasping labels.
Preparation and Properties of Bamboo Fiber/Nano-hydroxyapatite/Poly(lactic-co-glycolic) Composite Scaffold for Bone Tissue Engineering (2017)

In this study, bamboo fiber was first designed to incorporate into nano-hydroxyapatite/poly(lactic-co-glycolic) to obtain a new composite scaffold of bamboo fiber/nano-hydroxyapatite/poly(lactic-co- glycolic) (BF/n-HA/PLGA) by freeze-drying method. The effect of their components and some factors consisting of different freeze temperatures, concentrations, and pore-forming agents on the porous morphology, porosity, and compressive properties of the scaffold were investigated by scanning electron microscope, modified liquid displacement method, and electromechanical universal testing machine. The results indicated that the 5% BF/30% n-HA/PLGA composite scaffold, prepared with 5% (w/v) high concentration and frozen at -20 °C without pore-forming agent, had the best ideal porous structure and porosity as well as compressive properties, which far exceed those of n-HA/PLGA composite scaffold. In addition, the in vitro simulated body fluids soaking and cell culture experiment showed the addition of BF into the scaffold accelerated the BF/n-HA/PLGA composite scaffolds degradation and exhibited good cytocompatibility, including attachment and proliferation. All the results of the study show that BF has improved the properties of n-HA/PLGA composite scaffolds and BF/n-HA/PLGA might have a great potential for bone tissue engineering scaffold.
A review of cuffed vs uncuffed endotracheal tubes in children (2014)

Background The use of cuffed endotracheal tubes in paediatric patients is still a controversial topic. This paper aims to investigate whether cuffed or uncuffed tubes should be used in children under the age of 8 based on the literature that is currently available on this topic. Currently there are no guidelines on this topic. Methods The literature review has been taken in consideration Results The results of the first four studies all show significant results in favour of the use of cuffed endotracheal tubes. Cuffed endotracheal tubes were no more likely to cause
Structural Analysis for Wingspan Stent in a Perforator Model (2013)

Perforator infarction represents a critical problem after intracranial Wingspan stent. To explore the mechanism of perforator infarction, we simulated the stent-artery interaction at an atheromatous plaque with perforator. Structural deformation and biomechanical stress distribution after stenting were analyzed. High radial stress values were located along the stent struts, which surrounded the area with high circumferential stress. Stretched perforator orifice in a circumferential direction after stenting was simulated. These results show that structural deformation could play a role in the mechanism of perforator occlusion after Wingspan stenting.
The Origin of Chemical and Configurational Stability of Chiral Nonracemic tert-Butyl Aziridinecarboxylate Anions (2001)

The origin of good chemical and configurational stability of aziridine ester anions derived from (R)-(−)-phenylglycinol has been investigated. Kinetic acidity seems to play an important role in the deprotonation step and chemical stability of the anionic species. Spectroscopic investigations showed that the good overall retention of configuration was governed by the directing effect of the nitrogen atom, which acts as a stereogenic centre in the alkylation step of the enolate intermediate.
MRI of OATP-expressing transplanted cells using clinical doses of gadolinium contrast agent (2023)

Abstract Hepatic organic anion transporting polypeptides (OATPs) transport off-the-shelf, FDA-approved, hepatospecific Gd-based MRI contrast agents into cells that express the transporters enhancing signal on clinical T1-weighted MRI. Studies have used MRI to identify OATP-overexpressing tumors and metastases in mice following the delivery of Gd-EOB-DTPA at 27-67-fold higher than clinical doses. With safety and regulatory concern over Gd-based contrast agents, translation of this imaging paradigm to humans for regenerative medicine cell therapy will require substantially lower doses of agent. Here we complemented static T1-weighted MRI and/or T1-mapping with dynamic contrast enhanced (DCE)-MRI and show that even low intracellular accumulation of contrast agent results in a sustained signal enhancement in OATP-overexpressing tumors while control, non-expressing tumors have rapid wash-in and wash-out dynamics which could be distinguished by performing area-under-the-curve (AUC) analyses.
Management of the Placenta in Advanced Abdominal Pregnancies at an East African Tertiary Referral Center (2010)

Abdominal pregnancy is often detected rather late in low-resource settings compared with higher-resource settings. We suggest that in the described low-resource setting where red blood cell transfusions are not always readily available, the placenta may be left in situ after removal of the fetus.
Prevalence of Bacteremia And Meningitis In Febrile Infants ≤ 60 Days With Positive Urinalyses In A Multicenter Network (2021)

Background: Urinary tract infections (UTIs) are the most common serious bacterial infection in young febrile infants, and the urinalysis (UA) is an accurate screening test for emergency department (ED) evaluation. Precise estimates of risk of concomitant bacteremia and/or bacterial meningitis (invasive bacterial infections; IBI) in febrile infants ≤ 60 days have been based on presence of UTIs rather than positive UAs, and lack large prospective study. Objective: We sought to determine the prevalence of IBIs in febrile infants 0-28 …
Parasitic Component Small-Signal Modeling and Control of a Practical CLLC Resonant Converter (2022)

This article presents a comprehensive characterization of an asymmetric resonant CLLC dc/dc converter plant transfer function obtained using a generalized harmonic approximation (GHA)-based small-signal modeling approach. The effect of circuit parasitic components is comprehensively considered while deriving this model, and a quantified comparison of the resultant plant frequency response with a conventional first harmonic approximation (FHA)-based model is presented, which provides the designer insightful findings to design a robust and noise immune closed-loop compensator. Furthermore, a thorough explanation of a sliding mode control (SMC) along with detailed parameterization of the controller coefficients is provided by analyzing the system’s dynamic behavior and comparing the response with a conventional proportional–integral (PI)-based controller. In addition to the objective of designing a robust SMC controller, a phase shift-based secondary side modulation is introduced, which facilitates a significant reduction in the secondary side switching losses, thus enhancing the steady-state efficiency of the overall system. To validate and benchmark the open-loop plant response and controller dynamics, detailed steady-state results are elucidated for a 400–28- and 400–24-V voltage conversion at a rated load of 1 kW, with a resonant frequency of 500 kHz. Furthermore, a comprehensive experimental comparison between the proposed hybrid control scheme and the conventional PI controller is shown for two dynamic load changes corresponding to 10%–90% load step-up and 90%–10% load step-down. Quantification of dynamic response portrays a settling time reduction of 46.4% and an over/undershoot reduction of 33%, thus validating the robustness of the proposed control scheme.
Quantum state discrimination (2009)

It is a fundamental consequence of the superposition principle for quantum states that there must exist nonorthogonal states, that is, states that, although different, have a nonzero overlap. This finite overlap means that there is no way of determining with certainty in which of two such states a given physical system has been prepared. We review the various strategies that have been devised to discriminate optimally between nonorthogonal states and some of the optical experiments that have been performed to realize these.
Experimental Investigation of Using Ionic-Liquids as Alternatives of Surfactants in Enhanced-Oil-Recovery Processes for Harsh Carbonate Reservoirs (2021)

Summary Studies on the Ionic Liquids (ILs) as chemical agents for chemical enhanced oil recovery (CEOR) processes are very limited. The aims of this investigation are fulfilling a gap in the research on IL-based CEOR processes and showing the possibility to use the ILs as an alternative and influential agent on changing the reservoir rock and fluids properties. In this study, three cationic ILs including: 1-hexyl-3-methyl-imidazolium-chloride ([HMIM][Cl]), 1-methyl-3-octyl-imidazolium-chloride ([OMIM][Cl]) and 1-dodecyl-3-methyl-imidazolium-chloride ([DMIM][Cl]) were synthesized for CEOR process. According to obtained data from pendant drop interfacial tension (IFT) measurement tests, the critical micelle concentrations (CMC) of ILs in three different solutions with various total dissolved solids (TDS) include: Low Saline Water (LSW (TDS = 2000 ppm)), Formation Brine (FB (TDS = 195475.93 ppm)), and Sea Water (SW (TDS = 36250 ppm)). Also, some sessile drop contact angle measurement experiments were taken for evaluating the impacts of ILs on the wettability alteration mechanism for dolomite carbonate rock. Finally, several chemical flooding were conducted in dolomite coated micromodel system with dolomite pattern by determining the optimum concentrations of ILs. The recovery factor (RF) results showed that a flooding process after two pore volume injection could recover 80.28% (±1.0) of the original oil in place.
Methanotrophs for Clean-Up of Polluted Aquifers (1991)

Aquifers are vital reserves of drinking water which are under threat from pollution. Particular problems are posed by chlorinated compounds such as pesticides and solvents which native microbial populations are unable to degrade. Pump and treat regimes have proved unsuccessful since pollutants remain adsorbed to sediments but a possible solution is the use of introduced microorganisms to degrade pollutants in-situ. It is suggested that methanotrophs may be suitable candidates. Methanotrophs have an extraordinary range of degradative powers due to the non-specificity of their methane mono-oxygenase enzyme. We have shown that Methylosinus trichosporium OB3b is capable of degrading many common chlorinated pollutants co-metabolically when it is grown in a copper-depleted, oxygen-rich medium at neutral pH. In the subsurface however, such conditions do not exist and cultures grown in a medium made with untreated Cambridge aquifer water have a reduced range of degradative powers compared to similar cells grown in a medium made with distilled water. This means that to use methanotrophs for aquifer clean-up, the cells may need to be cultured above ground in ideal conditions and then introduced by some method of injection or infiltration. This may be possible because the degradative reactions are not coupled to growth and Methylosinus trichosporium OB3b cells maintain pollutant degrading ability up to 19 days after they have stopped growing. A suspension of these cells may thus be treated as a biocatalyst.
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2 (2006)

Accumulation of amyloid beta peptide (Abeta) in brain is a hallmark of Alzheimer's disease (AD). Inhibition of beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1), the enzyme that initiates Abeta production, and other Abeta-lowering strategies are commonly tested in transgenic mice overexpressing mutant APP. However, sporadic AD cases, which represent the majority of AD patients, are free from the mutation and do not necessarily have overproduction of APP. In addition, the commonly used Swedish mutant APP alters APP cleavage. Therefore, testing Abeta-lowering strategies in transgenic mice may not be optimal. In this study, we investigated the impact of BACE1 inhibition in non-transgenic mice with physiologically relevant APP expression. Existing Abeta ELISAs are either relatively insensitive to mouse Abeta or not specific to full-length Abeta. A newly developed ELISA detected a significant reduction of full-length soluble Abeta 1-40 in mice with the BACE1 homozygous gene deletion or BACE1 inhibitor treatment, while the level of x-40 Abeta was moderately reduced due to detection of non-full-length Abeta and compensatory activation of alpha-secretase. These results confirmed the feasibility of Abeta reduction through BACE1 inhibition under physiological conditions. Studies using our new ELISA in non-transgenic mice provide more accurate evaluation of Abeta-reducing strategies than was previously feasible.
On Parameter Estimation for Bandlimited Optical Intensity Channels (2019)

Parameter estimation is of paramount importance in every digital receiver. This is not only true for radio, but also for optical links; otherwise, subsequent processing stages, like detector units or error correction schemes, could not be operated reliably. However, for a bandlimited optical intensity channel, the problem of parameter estimation is strongly related to non-negative pulse shapes satisfying also the Nyquist criterion to keep the detection process as simple as possible. To the best of the author’s knowledge, it is the first time that both topics—parameter estimation on the one hand and bandlimited intensity modulation on the other—are jointly investigated. Since symbol timing and signal amplitude are the parameters of interest in this case, the corresponding Cramer–Rao lower bounds are derived as the theoretical limit of the jitter variance generated by the related estimator algorithms. In this context, a maximum likelihood solution is developed for the recovery of both timing and amplitude. Since this approach requires a receiver matched filter destroying the Nyquist criterion of the non-negative pulse shape, we compare it to a flat receiver filter preserving the required orthogonality property. It turned out that the jitter performance of the matched filter method is close to the Cramer–Rao lower bound in the medium-to-low SNR range, but due to inter-symbol interference effects an error floor emerges at higher SNR values. The flat filter solution avoids this drawback, although the price to be paid is a larger noise level at the filter output, so that a somewhat increased jitter variance is observed.
A NEWLY DEVELOPED LABORATORY SLAB ROLLER COMPACTOR (TURAMESIN): AN OVERVIEW (2008)

Methods of preparing test specimens in laboratories are particularly important. It also holds true in terms of compaction procedure in predicting pavement performance. The currently available laboratory compactor cannot adequately replicate field compaction conditions, especially the Stone Mastic Asphalt (SMA) mixture. The essential element of SMA mixture comprises of stones that are placed next to or on top of each other, and therefore are greatly affected by the compaction procedure. Conclusion of different studies have indicated that rolling wheel compactor, simulates properties that are closer to field compaction. Turamesin was developed as an improved method of laboratory slab roller compactor, to provide a solution for the problem of producing laboratory specimens, which would represent materials laid and compacted in the field. This paper gives an overview of Turamesin and discusses the findings of the units' first phase Pilot Study, conducted in order to provide specific information, to improve procedures for slab preparation and compaction,also determining the criteria for slab compaction and performance of Turamesin. Turamesin is able to compact, a slab area measuring; 600 mm by 500 mm, according to clients' specified thicknesses, with number of passes up to 75, within 15 minutes time period. One compacted slab could produce up to 16 cylindrical core specimens of 100 mm diameter. Turamesin has shown great potential to be adopted as standard laboratory slab compactor, for asphalt mixtures and seemes to be capable of simulating field compaction in terms of operational procedures. However, improvement of the Turamesin will need significant amount of research to develop and finalize the optimum procedures.
Critical dynamics of an asymmetrically bidirectionally pumped optical microresonator (2021)

An optical ring resonator with third-order, or Kerr, nonlinearity will exhibit symmetry breaking between the two counterpropagating circulating powers when pumped with sufficient power in both the clockwise and counterclockwise directions. This is due to the effects of self- and cross-phase modulation on the resonance frequencies in the two directions. The critical point of this symmetry breaking exhibits universal behaviors including divergent responsivity to external perturbations, critical slowing down, and scaling invariance. Here we derive a model for the critical dynamics of this system, first for a symmetrically pumped resonator and then for the general case of asymmetric pumping conditions and self- and cross-phase modulation coefficients. This theory not only provides a detailed understanding of the dynamical response of critical-point-enhanced optical gyroscopes and near-field sensors, but is also applicable to nonlinear critical points in a wide range of systems.
Materials Characterization by Dynamic and Modulated Thermal Analytical Techniques (2001)

Description STP 1402 examines the latest dynamic and modulated thermal analytical techniques, including new interpretations and applications of Differential Scanning Calorimetry (DSC). The basis of many DSC methods is the modulation of temperature along with varying other parameters. Dynamic methods, including Dynamic Mechanical Analysis (DMA) and Dielectric Thermal Analysis (DETA), are also critiqued with new innovative applications. The mode of modulation, a sinusoidal wave or a saw tooth curve, affords the thermal analyst an opportunity to study a physical or chemical change in greater detail. 15 peer reviewed papers cover: • Temperature Modulated Differential Scanning Calorimetry (TMDSC) • Use of TMDSC in Curing and Chemical Reactions • Measurement of the Glass Transition and Melting by Modulated and Comparative Techniques • General Modulated Techniques • Other Modulated Techniques • Dynamic Techniques DMA and DETA.