gebhart/patrepeval huggingface dataset:
Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis (2010)

This study is the first to show the immunoregulatory effect of VIP in humans, and supports the notion of inhaled VIP as an attractive future therapy to dampen exaggerated immune responses in lung disorders. Thus, the inhalation of neuropeptides may be developed into a new therapeutic principle for chronic inflammatory lung disorders in humans.
Delivering interactive services via a digital TV infrastructure (1998)

This article discusses an architecture for interactive service delivery to the home via the digital television (DTV) infrastructure in systems with and without return channels. This approach relies on a broadcast computing model adapted to suit the DTV environment. The model works even with low-cost user terminals, such as the basic DTV set-top boxes with limited computational and graphics capability and no local disk storage.
Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena (2013)

The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms, are key in the fight against the proteotoxicity that is often associated with severe neurodegenerative diseases. However, in recent years, a new theme has emerged which suggests that components of protein quality-control pathways are often targets of the toxic effects of pathogenic proteins and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as 'saviour' and 'victim' in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic proteins in lysosomes.
Dihydrophenanthrenes from a Sicilian Accession of Himantoglossum robertianum (Loisel.) P. Delforge Showed Antioxidant, Antimicrobial, and Antiproliferative Activities (2021)

The peculiar aspect that emerges from the study of Orchidaceae is the presence of various molecules, which are particularly interesting for pharmaceutical chemistry due to their wide range of biological resources. The aim of our study was to investigate the properties of two dihydrophenanthrenes, isolated, for the first time, from <i>Himantoglossum robertianum</i> (Loisel.) P. Delforge (Orchidaceae) bulbs and roots. Chemical and spectroscopic study of the bulbs and roots of <i>Himantoglossum</i><i>robertianum</i> (Loisel.) P. Delforge resulted in the isolation of two known dihydrophenanthrenes-loroglossol and hircinol-never isolated from this plant species. The structures were evaluated based on <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and two-dimensional spectra, and by comparison with the literature. These two molecules have been tested for their possible antioxidant, antimicrobial, antiproliferative, and proapoptotic activities. In particular, it has been shown that these molecules cause an increase in the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) in polymorphonuclear leukocytes (PMN); show antimicrobial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, and have anti-proliferative effects on gastric cancer cell lines, inducing apoptosis effects. Therefore, these two molecules could be considered promising candidates for pharmaceutical and nutraceutical preparations.
Sequence-Specific Alkylation of dsDNA with Derivatives of Pyrimidine Oligonucleotides Conjugated to 2-Chloroethylamine Groups (1991)

Reaction of homopyrimidine oligonucleotides bearing a 5'-terminal alkylating aromatic 2-chloroethyl-amino group with a bovine papilloma vector expressing human interferon-gamma was investigated. The oligonucleotide derivatives bound to corresponding homopurine-homopyrimidine sequences in dsDNA and alkylated guanosine residues at these sites in the purine strand of the target. The alkylated DNA can be cleaved at the modified residues. At pH 5.4, the reaction was highly specific to the target sequences; at pH less than 5, some nonspecific reactions were observed at the sequences partially complementary to the oligonucleotides. Elongation of the linker between the alkylating group and the oligonucleotide phosphate increased the alkylation efficiency. Repeated treatment of the DNA with gradually increased concentrations of the reagent resulted in quantitative modification of the target guanosines.
Highly Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Enantioselective, Catalytic Epoxidation of Trisubstituted OlefinsBridget D. Brandes and Eric N. JacobsenCite this: J. Org. Chem. 1994, 59, 16, 4378–4380Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://doi.org/10.1021/jo00095a009Request reuse permissionsArticle Views6112Altmetric-Citations223LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (307 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effect of Surface Properties of Iron Ores on their Granulation Behavior (2013)

The granulation property of iron ores was generally influenced by their wettability, surface roughness and shape of the iron ore. In this study, the surface roughness and shape of iron ores were characterized by the ratio of BET specific surface area (SBET) to specific surface area (SLS) calculated using size distribution obtained by a laser diffraction method. Wettability of ores was characterized by measuring the contact angle (θ) between iron ore and water. Bed permeability was used as an evaluation index of granulation effect. A variety of materials were subjected to a granulation test under an actual production condition. Special attention was paid to four ores with different surface properties and wettabilities. Nine groups of mixtures were obtained by linear programming taking the basicity as the objective function. Granulation results showed that the optimum bed permeability of nine mixtures have a good linear relation with mass fraction of four ores studied. Slopes (k) of fitting lines were used to characterize the granulation properties of ores, binary linear regression equation was derived with the k used as dependent variable, θ and SBET/SLS used as independent variables: k=16.443–0.277×θ+0.058×(SBET/SLS), Granulation performance of iron ore gets better with decreasing the contact angle and increasing the ratio of SBET to SLS.
Demonstration: a restful SOS proxy for linked sensor data (2011)

Abstract. Next generations of spatial information infrastructures call for more dynamic service composition, more sources of information, as well as stronger capabilities for their integration. Sensor networks have been identified as a ma-jor data provider for such infrastructures, while Semantic Web technologies have demonstrated their integration capabilities. Most sensor data is stored and ac-cessed using the Observations &amp;amp; Measurements (O&amp;amp;M) standard of the Open Geospatial Consortium (OGC) as data model. However, with the advent of the Semantic Sensor Web, work on an ontological model gained importance within Sensor Web Enablement (SWE). The ongoing paradigm shift to Linked Sensor Data complements this attempt and also adds interlinking as a new challenge. In this demonstration paper, we briefly present a Linked Data model and a RESTful proxy for OGC’s Sensor Observation Service (SOS) to improve integration and inter-linkage of observation data.
Nanocrystal Memory Cell Integration in a Stand-Alone 16-Mb nor Flash Device (2007)

We report on the full process integration of nanocrystal (NC) memory cells in a stand-alone 16-Mb NOR Flash device. The Si NCs are deposited by chemical vapor deposition on a thin tunnel oxide, whose surface is treated with a low thermal budget process, which increases NC density and minimizes oxide degradation. The device fabrication has been obtained by means of conventional Flash technology, which is integrated with the CMOS periphery with high- and low-voltage transistors and charge pump capacitors. The memory program and erase threshold voltage distributions are well separated and narrow. The voltage distribution widths are related to NC sizes and dispersion, and bigger NCs can induce a cell reliability weakness. An endurance issue is also related to the use of an oxide/nitride/oxide dielectric which acts as a charge trapping layer, causing a shift in the program/erase window and a distribution broadening during cycling.
Spin dependent Drell-Yan in QCD to O({alpha}{sub s}{sup 2}) (I). (The non-singlet sector) (1997)

A study of the order {alpha}{sub s}{sup 2} corrections to the Drell-Yan (non-singlet) cross section for incoming states of arbitrary longitudinal helicities is presented. The study is performed in the case of the transverse momentum distributions, q{sub T}, of the lepton pair and extends the calculation of Ellis Martinelli and Petronzio (EMP) to the polarized case. They use the {ovr MS} scheme and the t'Hooft-Veltman regularization for the helicity projectors. From their results one can obtain the bulk of the totally inclusive NNLO cross section for the production of a Drell-Yan pair in the non-singlet sector by a simple integration over the heavy photon momentum. They show that in the {ovr MS} helicity is not conserved, unless a finite renormalization is done to reenter into a physical ({ovr MS}{sub p}) scheme. This aspect of the calculation follows the same trend as in polarized production of single and double photon to O({alpha}{sub s}{sup 2}). In the unpolarized limit they reproduce all the results of EMP.
An in vitro screening method for probiotics with antidepressant-like effect using the enterochromaffin cell model (2021)

Certain probiotics can regulate the host's neurobehavioral function through the microbiota-gut-brain axis. However, screening these probiotics is mainly carried out in animal models, and is costly and inefficient. Herein, a putative enterochromaffin cell line (RIN14B) was used as an in vitro pre-screening model; 30 bacterial strains were tested for bacteria-stimulated tryptophan hydroxylase 1 gene (Tph1) expression and 5-hydroxytryptophan/5-hydroxytryptamine secretion. All strains were further validated for their neurobehavioral effects in chronic stress-induced depressive mice. Using partial least squares (PLS) modeling of in vitro and in vivo datasets, we found that the level of Tph1 mRNA in RIN14B significantly correlated with the performance of a forced swim test and sucrose preference test, and serum corticosterone level in chronically stressed mice. Four strains were identified as the best candidates among 30 strains using principal component analysis on all in vivo measures, and unsurprisingly, three of them could enhance Tph1 expression in RIN14B, which further proved that the RIN14B-based screening method (especially the detection of bacteria-stimulated Tph1 mRNA) has good predictive validity and screening efficiency for the strain's antidepressant-like capacity. Collectively, this study provides a novel in vitro method for screening probiotics (or other related bioproducts) with antidepressant-like potential.
Supplementary Fig 10 from WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers (2023)

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Induction of Flexibility through Protein-Protein Interactions (2003)

The dimerization/docking (D/D) domain of the cyclic AMP-dependent protein kinase (PKA) holoenzyme mediates important protein-protein interactions that direct the subcellular localization of the enzyme. A kinase anchoring proteins (AKAPs) provide the molecular scaffold for the localization of PKA. The recent solution structures of two D/D AKAP complexes revealed that the AKAP binds to a surface-exposed, hydrophobic groove on the D/D. In the present study, we present an analysis of the changes in hydrogen/deuterium exchange protection and internal motions of the backbone of the D/D when free and bound to the prototype anchoring protein, Ht31(pep). We observe that formation of the complex results in significant, but small, increases in H/D exchange protection factors as well as increases in backbone flexibility, throughout the D/D, and in particular, in the hydrophobic binding groove. This unusual observation of increased backbone flexibility and marginal H/D exchange protection, despite high affinity protein-ligand interactions, may be a general effect observed for the stabilization of hydrophobic ligand/hydrophobic pocket interactions.
A Hardware in Loop Test System for Pneumatic Anti-lock Brake System (2010)

Pneumatic Anti-lock Brake System has been widely used in commercial vehicles such as trucks, tractor-trailers and buses today. These brake systems are equipped on the vehicle's axle, and compressed air is used as the energy transmitting medium to actuate brake actuator. Here, we present one method of evaluating and testing the ABS controller and the algorithm for full-air brake system, and a Hardware-In-Loop simulator is made in our laboratory. This testing system includes actual pneumatic brake actuator between ABS controller and vehicle dynamics model, thus simulates a real truck under braking in real time. In this paper, the method of modeling a vehicle dynamics used for simulation is introduced, and how constructing the Hardware-In-Loop testing system is described. Using this testing system, we can finish performance tests for ABS controller in a short time. And thus, we can reduce time and cost needed for developing the pneumatic ABS controller for commercial vehicles.
Children's search roles at home: Implications for designers, researchers, educators, and parents (2011)

Abstract This paper presents the results of a large‐scale, qualitative study conducted in the homes of children aged 7, 9, and 11 investigating internet searching processes on Google. Seven search roles, representing distinct behavior patterns displayed by children when interacting with the Google search engine, are described, including Developing Searchers, Domain‐specific Searchers, Power Searchers, Nonmotivated Searchers, Distracted Searchers, Rule‐bound Searchers, and Visual Searchers. Other trends are described and selected to present a view of the whole child searcher. These roles and trends are used to make recommendations to designers, researchers, educators, and parents about the directions to take when considering how to best aid children to become search literate.
Rule-based versus training-based extraction of index terms from business documents: how to combine the results (2013)

Current systems for automatic extraction of index terms from business documents either take a rule-based or training-based approach. As both approaches have their advantages and disadvantages it seems natural to combine both methods to get the best of both worlds. We present a combination method with the steps selection, normalization, and combination based on comparable scores produced during extraction. Furthermore, novel evaluation metrics are developed to support the assessment of each step in an existing extraction system. Our methods were evaluated on an example extraction system with three individual extractors and a corpus of 12,000 scanned business documents.
Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia (2014)

Cognitive deficits represent a significant characteristic of schizophrenia. However, a majority of the clinical studies have been conducted in antipsychotic drug treated patients. Thus, it remains unclear if significant cognitive impairments exist in the absence of medication. This is the first meta-analysis of cognitive findings in drug-naïve patients with schizophrenia. Cognitive data from 23 studies encompassing 1106 patients and 1385 controls published from 1992 to 2013 were included. Tests were to a large extent ordered in cognitive domains according to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) battery. Analysis was performed with STATA using the random-effects model and heterogeneity as well as Egger's publication bias was assessed. Overall the results show that patients performed worse than healthy controls in all cognitive domains with medium to large effect sizes. Verbal memory, speed of processing and working memory were three of the domains with the greatest impairments. The pattern of results is in line with previous meta-analytic findings in antipsychotic treated patients. The present meta-analysis confirms the existence of significant cognitive impairments at the early stage of the illness in the absence of antipsychotic medication.
On Effective Scheduling in Computing Clusters (2019)

Presently, big companies such as Amazon, Google, Facebook, Microsoft, and Yahoo! own huge datacenters with thousands of nodes. These clusters are used simultaneously by many clients. The users submit jobs containing one or more tasks. The task flow is usually a mix of short, long, interactive, and batch tasks with different priorities. The cluster scheduler decides on which server the task should be run as a process, container, or virtual machine. Scheduler optimizations are important as they provide higher server utilization, lower latency, improved load balancing, and fault tolerance. Optimal task placement is a complex problem that has multiple dimensions and requires algorithmically complex optimizations. This increases placement latency and limits cluster scalability. In this paper, we consider different cluster scheduler architectures and optimization problems.
Extended resection of sarcomas involving the mediastinum: a 15-year experience (2015)

CPB and concomitant resection of intrathoracic structures may be required for local tumour control in sarcomas that involve the mediastinum, and should not be considered contraindications to resection as they may offer the best opportunity for prolonged survival in selected cases.
Quantum confinement effects in amorphous In–Ga–Zn–O thin-film transistors with quantum well channel (2022)

We confirmed that quantum confinement effects are clearly observed even in a disordered material. Employing amorphous In–Ga–Zn–O (a-IGZO) thin-film transistors (TFTs) with quantum well channels, it was observed that field-effect mobility–gate voltage relations exhibited plateaus when the well thickness was 5 nm or less. Device simulation incorporating the quantum confinement effects reproduced the well-thickness dependence of the plateau onset voltage, verifying that the quantized electronic levels in the a-IGZO well dominate the TFT characteristics and, thus, the electron transport is free electron like with a coherent length of ∼5 nm. The field-effect mobility did not exceed the drift mobility of bulk a-IGZO, which is different from amorphous silicon superlattice TFT.
System identification and resolved acceleration control of space robots by using experimental system (2002)

An experimental system is constructed to evaluate performance and feasibility of modeling, identification and control methods for space robots. The experimental system achieves a two-dimensional weightless condition by means of a horizontal table and air-pads. As a preliminary experimental study, two identification methods for space robots are discussed. The first identification method is a conventional method for manipulators on an inertially fixed base. The second identification method can determine dynamic parameters of space robots under the condition that the satellite base is free to both translate and rotate. This method is based upon the conservation laws of linear and angular momentum of a space robot. Finally implementation schemes of resolved acceleration control are considered for the experimental system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Separation Free DNA Detection Using Surface Enhanced Raman Scattering (2011)

Surface enhanced raman scattering (SERS) based molecular diagnostic assays for the detection of specific DNA sequences have been developed in recent years to compete with the more common fluorescence based approaches. Current SERS assays either require time-consuming separation steps that increase assay cost and can also increase the risk of contamination or they are negative assays, where the signal intensity decreases in the presence of target DNA. Herein, we report a new separation free SERS assay with an increase in signal intensity when target DNA is present using a specifically designed SERS primer. The presence of specific bacterial DNA from Staphylococcus epidermidis was detected using polymerase chain reaction (PCR) and SERS and indicates a new opportunity for exploration of SERS assays requiring minimal handling steps.
« 177. Fille aînée du christianisme oriental ? », dans P. Boucheron (dir.), Histoire mondiale de la France, Paris, Seuil, 2017, p. 66-70. (2017)

International audience
Influence of Technology in The Hospitality Industry (2019)

The purpose of this research is to study how technology impacts consumer behavior within the hospitality sector with the introduction of mobile and the Internet of Things and social media. With the rapid development of technologies, the social behavior habits of consumers have significantly changed and are no longer in line with non-internet era. As digital technologies have greater integration in our everyday life, the hospitality sector, in this case restaurants, needs to be adapted respectively with deeper integration of newer technologies within its environment. 203 respondents responded to a questionnaire launched online. Another 1534 were observed to solidify the survey results. Respondents and those observed were classified into three groups – students, working professionals, and travelers. Data were analyzed by statistical program SPSS to show the mean, standard deviation, t-test, and significant values. Our study shows that current mobile applications lack the integration of significant factors found essential to consumers in the hospitality industry. The factors are the venue quality, convenience, transportation time, parking space, and whom to go with. It is vital for the hospitality industry to capture these factors and integrate the Internet of Things.