gebhart/patrepeval huggingface dataset:
Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. (1995)

The expression pattern of E- and P-cadherin in human carcinomas has been reported by many laboratories. However, little is known about the involvement of other cadherin types in human carcinomas. cDNA clones for a cadherin molecule were isolated from a cDNA library of human hepatocellular carcinoma cells which lacked E- and P-cadherin expression but exhibited cell aggregation activity mediated by an unknown cadherin, and they were subjected to sequence analysis. The overlapped clones covered 4315 nucleotides and were found to encode a typical cadherin molecule consisting of 790 amino acids. Since the deduced amino acid sequence was identical to a partially available human cadherin-6 sequence except for two amino acid residues, the clones were considered to be human cadherin-6 cDNAs encoding the entire open reading frame. The deduced amino acid sequence also showed extremely high homology with recently reported rat K-cadherin, 97% for the putative mature protein, suggesting that cadherin-6 is the human counterpart of rat K-cadherin. Expression of cadherin-6 in various human normal tissues and carcinoma cells was examined by Northern blot analysis using a specific probe corresponding to the signal and precursor sequence. Among normal tissues examined, brain, cerebellum, and kidney showed strong expression of cadherin-6, whereas lung, pancreas, and gastric mucosa showed weak expression. Transcripts of cadherin-6 were not detected in normal liver, whereas four of six hepatocellular carcinoma cell lines examined expressed cadherin-6 abundantly. As reported for rat K-cadherin, three renal carcinoma cell lines also expressed cadherin-6 strongly. The most interesting finding was obtained for small cell lung carcinoma lines. Among 15 of such cell lines examined, all of 11 cadherin-6-positive lines were classified into the classic type, whereas the negative cell lines were all of the variant type. The present results suggest that besides E- and P-cadherin, other cadherin molecules are expressed in human cancers and are responsible for additional biological properties of the carcinoma cells.
Nanomaterials for Biosensors. Nanotechnologies for the Life Sciences, Volume 8 Edited by Challa S. S. R. Kumar (Louisiana State University, Baton Rouge). Wiley-VCH Verlag GmbH & Co. KGaA:  Weinheim. 2007. xxii + 408 pp. $175.00 ISBN 978-3-527-31388-4. (2007)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTNanomaterials for Biosensors. Nanotechnologies for the Life Sciences, Volume 8 Edited by Challa S. S. R. Kumar (Louisiana State University, Baton Rouge). Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim. 2007. xxii + 408 pp. $175.00 ISBN 978-3-527-31388-4.Paul PantanoView Author Information The University of Texas at DallasCite this: J. Am. Chem. Soc. 2007, 129, 35, 10963Publication Date (Web):August 4, 2007Publication History Published online4 August 2007Published inissue 1 September 2007https://pubs.acs.org/doi/10.1021/ja0769393https://doi.org/10.1021/ja0769393book-reviewACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views280Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Nanomaterials,Nanoparticles,Nanotechnology,Sensors Get e-Alerts
500. Fluorinated sulphonic acids. Part I. Perfluoro-methane-, -octane-, and -decane-sulphonic acids and their simple derivatives (1957)

J. Burdon, I. Farazmand, M. Stacey and J. C. Tatlow, J. Chem. Soc., 1957, 2574 DOI: 10.1039/JR9570002574
Genetic and molecular characterization of murine GATA‐1 in Aspergillus defines a critical role for the N‐terminal finger (1997)

We have utilized Aspergillus nidulans as a model system for the characterization of the major vertebrate transcription factor GATA-1. This has been achieved both by analysing the function of murine GATA-1 directly and by using direct gene replacement to introduce chimaeric areA::GATA-1 derivatives at the areA locus, which encodes a GATA factor involved in regulating nitrogen metabolism in A. nidulans. Although GATA-1 shows only limited function when expressed in A. nidulans, the C-terminal GATA DNA-binding domain can replace the native GATA domain of AREA and retain near wild-type function. Surprisingly, inclusion of the N-terminal DNA-binding domain of GATA-1 has a major role in determining the function of areA::GATA constructs in vivo, leading to a general loss of activation. This negative function is partially dominant and is dependent on both the fidelity of the zinc-chelating structure and a second factor encoded by A. nidulans. The presence of two GATA domains also disrupts modulation of AREA activity. The ability of duplicate GATA domains to disrupt normal signal transduction is not dependent on the relative position of the domains or on the fidelity of the zinc-chelating structure. This demonstrates the utility of nitrogen metabolism's regulation in A. nidulans as a model system for the molecular and genetic characterization of heterologous GATA factors while also providing insights into native Aspergillus regulatory components.
Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase (2015)

Lasso peptide isopeptidase is an enzyme that specifically hydrolyzes the isopeptide bond of lasso peptides, rendering these peptides linear. To carry out a detailed structure-activity analysis of the lasso peptide isopeptidase AtxE2 from Asticcacaulis excentricus, we solved NMR structures of its substrates astexin-2 and astexin-3. Using in vitro enzyme assays, we show that the C-terminal tail portion of these peptides is dispensable with regards to isopeptidase activity. A collection of astexin-2 and astexin-3 variants with alanine substitutions at each position within the ring and the loop was constructed, and we showed that all of these peptides except for one were cleaved by the isopeptidase. Thus, much like the lasso peptide biosynthetic enzymes, lasso peptide isopeptidase has broad substrate specificity. Quantitative analysis of the cleavage reactions indicated that alanine substitutions in loop positions of these peptides led to reduced cleavage, suggesting that the loop is serving as a recognition element for the isopeptidase.
NeuroBiometric: An eye blink based biometric authentication system using an event-based neuromorphic vision sensor (2021)

The rise of the Internet and identity authentication systems has brought convenience to people's lives but has also introduced the potential risk of privacy leaks. Existing biometric authentication systems based on explicit and static features bear the risk of being attacked by mimicked data. This work proposes a highly efficient biometric authentication system based on transient eye blink signals that are precisely captured by a neuromorphic vision sensor with microsecond-level temporal resolution. The neuromorphic vision sensor only transmits the local pixel-level changes induced by the eye blinks when they occur, which leads to advantageous characteristics such as an ultra-low latency response. We first propose a set of effective biometric features describing the motion, speed, energy and frequency signal of eye blinks based on the microsecond temporal resolution of event densities. We then train the ensemble model and non-ensemble model with our NeuroBiometric dataset for biometrics authentication. The experiments show that our system is able to identify and verify the subjects with the ensemble model at an accuracy of 0.948 and with the non-ensemble model at an accuracy of 0.925. The low false positive rates (about 0.002) and the highly dynamic features are not only hard to reproduce but also avoid recording visible characteristics of a user's appearance. The proposed system sheds light on a new path towards safer authentication using neuromorphic vision sensors.
The Interactive Advertising Model (2000)

The authors provide an integrative processing model of Internet advertising, which incorporates the functional and structural schools of thought. The model begins with the functional perspective, which attempts to identify reasons for Internet use. Since most individuals enter cyberspace with some goal, or agenda, in mind, the authors argue that a model of online processing should begin with consideration of Internet functions. These functions, according to the authors, operate conjointly with the user’s mode--ranging from highly goal-directed to playful--to influence the types of ads web users will attend to and process. A number of mediating variables, such as skill level, are offered as reasons to switch motives. These variables are conceptualized as having either a deleterious effect, as in the case of low skill and high anxiety, or beneficial effect, as in the case of high skill and low anxiety, on ad processing. Last, the authors incorporate a structural perspective, which seeks to identify and classify Internet ads. The authors offer a broad scheme in which to classify most Internet ads, as well as a number of common features unique to these ads. The authors conclude by offering a number of hypotheses suggested by the model.
Minimal Multi-threading: Finding and Removing Redundant Instructions in Multi-threaded Processors (2010)

Parallelism is the key to continued performance scaling in modern microprocessors. Yet we observe that this parallelism can often contain a surprising amount of instruction redundancy. We propose to exploit this redundancy to improve performance and decrease energy consumption. We propose a multi-threading micro-architecture, Minimal Multi-Threading (MMT), that leverages register renaming and the instruction window to combine the fetch and execution of identical instructions between threads in SPMD applications. While many techniques exploit intra-thread similarities by detecting when a later instruction may use an earlier result, MMT exploits inter-thread similarities by, whenever possible, fetching instructions from different threads together and only splitting them if the computation is unique. With two threads, our design achieves a speedup of 1.15 (geometric mean) over a two-thread traditional SMT with a trace cache. With four threads, our design achieves a speedup of 1.25 (geometric mean) over a traditional SMT processor with four-threads and a trace cache. These correspond to speedups of 1.5 and 1.84 over a traditional out-of-order processor. Moreover, our performance increases in most applications with no power increase because the increase in overhead is countered with a decrease in cache accesses, leading to a decrease in energy consumption for all applications.
High performance sensorless control of induction motor drives for industry applications (2002)

This paper deals with some aspects concerning the implementation of a sensorless induction motor control for industry applications. The proposed control method uses an adaptive rotor flux observer and a suitable adaptation law for the speed estimation. It has been found that this method is superior to many other methods when the performance versus complexity criterion is considered. The adaptation law is obtained by a general one, valid for any induction motor parameter estimation. A comparison between the floating and the fixed point DSP implementation of the proposed method is presented. In fact, the appearance of new and powerful fixed point DSP microcontrollers makes the fixed point solution very attractive for many industrial applications, such as retrofits, conveyors control, and a lot of manufacturing process control. Different algorithm implementation issues, such as the online computation of the observer gain matrix and of the discrete motor model are discussed in this paper. Simulation and experimental results for the two cases (fixed and floating point DSP implementation) are shown.
Sulong, and Thanks for All the Bugs (2018)

In C, memory errors, such as buffer overflows, are among the most dangerous software errors; as we show, they are still on the rise. Current dynamic bug-finding tools that try to detect such errors are based on the low-level execution model of the underlying machine. They insert additional checks in an ad-hoc fashion, which makes them prone to omitting checks for corner cases. To address this, we devised a novel approach to finding bugs during the execution of a program. At the core of this approach is an interpreter written in a high-level language that performs automatic checks (such as bounds, NULL, and type checks). By mapping data structures in C to those of the high-level language, accesses are automatically checked and bugs discovered. We have implemented this approach and show that our tool (called Safe Sulong) can find bugs that state-of-the-art tools overlook, such as out-of-bounds accesses to the main function arguments.
Building and applying a human cognition model for visual analytics (2009)

It is well known that visual analytics addresses the difficulty of evaluating and processing large quantities of information. Less often discussed are the increasingly complex analytic and reasoning processes that must be applied in order to accomplish that goal. Success of the visual analytics approach will require us to develop new visualization models that predict how computational processes might facilitate human insight and guide the flow of human reasoning. In this paper, we seek to advance visualization methods by proposing a framework for human 'higher cognition' that extends more familiar perceptual models. Based on this approach, we suggest guidelines for the development of visual interfaces that better integrate complementary capabilities of humans and computers. Although many of these recommendations are novel, some can be found in existing visual analytics applications. In the latter case, much of the value of our contribution lies in the deeper rationale that the model provides for those principles. Lastly, we assess these visual analytics guidelines through the evaluation of several visualization examples.
On a new way to read data from memory (2003)

This paper explains a new family of techniques to extract data from semiconductor memory, without using the read-out circuitry provided for the purpose. What these techniques have in common is the use of semi-invasive probing methods to induce measurable changes in the analogue characteristics of the memory cells of interest. The basic idea is that when a memory cell, or read-out amplifier, is scanned appropriately with a laser, the resulting increase in leakage current depends on its state; the same happens when we induce an eddy current in a cell. These perturbations can be carried out at a level that does not modify the stored value, but still enables it to be read out. Our techniques build on it number of recent advances in semi-invasive attack techniques, low temperature data remanence, electromagnetic analysis and eddy current induction. They can be used against a wide range of memory structures, from registers through RAM to FLASH. We have demonstrated their practicality by reading out DES keys stored in RAM without using the normal read-out circuits. This suggests that vendors of products such as smartcards and secure microcontrollers should review their memory encryption, access control and other storage security issues with care.
Morphological and virological investigations of cell strains cultured from the brain in Jakob-Creutzfeldt disease and subacute sclerosing panencephalitis. (1975)

Cell strains were established in culture from fragments of the brain from 2 cases each of Jakob-Creutzfeldt (JC) disease and subacute sclerosing panencephalitis (SSPE). After about 12 weeks strains from the former spontaneously formed persistent heaped up nodules of cells which appeared to produce reticulin-like fibrils as well as confluent sheets of rounded and spindle, fibroblast-like cells. Similar sheets of cells were obtained from the cases of SSPE but the only nodules formed were smaller and ephemeral. Attempts to detect virus in all 4 strains were made by inoculation of supernatant fluids into cultures of other laboratory cells, haemadsorption, co-cultivation, electron microscopy and immunofluorescence, and testing for interferon production. No evidence was found by any of these methods of the persistent presence of virus in the strains. Immunofluorescence revealed a probable anti-glial cell IgM autoantibody in one case of JC disease. Morphologically some cells resembled astrocytes and others fibroblasts. Those from JC disease contained more vacuoles and redundant membranes than did those from the cases of SSPE, features that are particularly striking in brain cells in human and animal cases of the spongiform encephalopathies.
Systems Physiology: Cardiovascular THRESHOLD CHANGES IN BLOOD LACTATE, BEAT-TO-CARDIOVASCULAR FUNCTION, AND BREATH-BY-BREATH VO 2 DURING INCREMENTAL EXERCISE (2002)

THRESHOLD CHANGES IN BLOOD LACTATE, BEAT-TO-CARDIOVASCULAR FUNCTION, AND BREATH-BY-BREATH VO2 DURING INCREMENTAL EXERCISE. Melissa Knight-Maloney, Robert A. Robergs, Ann Gibson, Farzenah Ghiasvand. JEPonline. 2002;5(3):39-53. The relationships between the systolic blood pressure threshold (ST), heart rate (HR) threshold (HT), rate pressure product threshold (RT), lactate threshold (LT) and ventilatory threshold (VT) were studied in 14 subjects (10 males, 4 females). All subjects performed an incremental cycle ergometer test to volitional exhaustion. HR data was collected via ECG. SBP was determined beat by beat by tonometry. The LT and VT were determined through standard methods. The threshold or breakpoint for SBP, HR and RPP, as a function of VO 2, was determined as the deviation from linearity when the data were analyzed with non-linear regression analysis. When the pre and post threshold slopes for SBP, HR and RPP were analyzed it was found that most subjects demonstrated either an increased or decreased response post-threshold. The threshold responses were analyzed using two-way ANOVA. For SBP, it was found there was no significant difference in pre and post-threshold SBP in subjects that demonstrated an increase in SBP slope post-threshold (p=0.36). In contrast, there was a significant difference between the pre and post-threshold slopes for the subjects that exhibited a decreased post-threshold SBP response (p=0.000). The analysis of the HR data pre and post HT revealed differences in pre and post- threshold slopes for those subjects that demonstrated an increase HR response post-threshold (p=0.003) and those that exhibited a decreased post-threshold HR response (p=0.001). There was no significant difference in the pre and post-threshold RPP responses for either the group that demonstrated an increased post-threshold response or the group that demonstrated a decreased RPP response post-threshold. Two-way ANOVA revealed significant differences between the VO2 at the RT (2.17±0.26 L/min) and LT (1.84±0.13 L/min) (p=0.011) and the RT and VT (1.87±0.11 L/min) (p=0.011). There were also significant differences between HT (2.24±0.14 L/min) and LT (p=0.0019) and HT and VT (p=0.0025), indicating that the RT occurs at a significantly different VO2 than either the LT or VT. In summary, differences were noted in the pre and post threshold responses for SBP and HR. The RPP slopes were inconsistent between subjects due to both positive and negative changes in
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia (2013)

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia (AML) have identified frequent somatic mutations in genes that encode proteins important in the epigenetic regulation of gene transcription. This includes proteins involved in the modification of DNA cytosine residues and enzymes which catalyze posttranslational modifications of histones. Here we describe the clinical, biological, and therapeutic relevance of mutations in epigenetic regulators in AML. In particular, we focus on the role of loss-of-function mutations in TET2, gain-of-function mutations in IDH1 and IDH2, and loss-of-function mutations in ASXL1 and mutations of unclear impact in DNMT3A in AML pathogenesis and therapy. Multiple studies have consistently identified that mutations in these genes have prognostic relevance, particularly in intermediate-risk AML patients, arguing for inclusion of mutational testing of these genetic abnormalities in routine clinical practice. Moreover, biochemical, biological, and epigenomic analyses of the effects of these mutations have informed the development of novel therapies which target pathways deregulated by these mutations. Our understanding of the effects of these mutations on hematopoiesis and potential for therapeutic targeting of specific AML subsets is also reviewed here.
Beam Pattern Analysis of Antenna Array on Complex Platform Using AEP Method Based on Hybrid UTD-ACGF Technique (2017)

For accurate beam analysis of a radiating antenna array on a complex platform, the mutual coupling and platform scattering effects are important. We proposed a beam pattern analysis method for an antenna array on a complex platform, which combines the active element pattern method of the receiving mode and hybrid geometrical theory of diffraction antenna current Green's function technique. This proposed method clearly and mathematically divides the beam pattern of the antenna array on a complex platform into mutual coupling and platform scattering components. For a 12 linear dipole array embedded in a complex aircraft, analyses of the beam pattern and boresight error using the proposed method were verified with the method of moment results, which were simulated with FEKO. With reasonably good accuracy, the proposed method can efficiently analyze a beam pattern reflecting the mutual coupling effect and the platform scattering effect. Additionally, convex optimization with the proposed method is simply applied to synthesize the compensated beam pattern.
Evaporation in Capillary Porous Media: An Experimental and Numerical Network Study (1995)

Abstract We use experimental and numerical network models to study evaporation in porous media. Very good agreement is obtained between the experiments and the simulations. The results show phase distribution patterns of invasion percolation type. However, evaporation is characterized by the gradual erosion of the disconnected liquid clusters that form during the process. This leads to phase distributions that markedly differ from standard invasion percolation patterns. The three dimensional simulations offer a nice explanation of the “dry patches” phenomenon reported in various studies of drying. A simulation and an experiment for macroscopically heterogeneous systems reveal that the evolution of the phase distributions during evaporation is very sensitive to the macroscopic heterogeneities. In addition, we briefly discuss the role of film flows, which are evidenced by a specific experiment, as well as the influence of the viscous forces which are not taken into account in the present version of the numerical network simulator.