gebhart/patrepeval huggingface dataset:
HPV genotypes detected in cervical cancers from Alaska Native women, 1980–2007 (2013)

Overall, almost two-thirds (61.2%) of the archived cervical cancers had detectible HPV types 16 or 18, a finding similar to studies of US women. As expected, a proportion of cancers would not be prevented by the current vaccines. HPV vaccination and cervical cancer screening are important prevention strategies for AN women.
Transgenic Fish and Public Policy: Regulatory Concerns (1990)

The present status of public policies regarding laboratory production, field testing, and distribution and final use of transgenic animals is reviewed from the perspective of fisheries professionals. Unsettled policy issues center upon distribution and final use of transgenic fishes. Policy positions regarding regulation of the various stages of production of transgenic fishes are recommended for adoption by fisheries professionals.
Machine Learning Methods for User Positioning With Uplink RSS in Distributed Massive MIMO (2018)

We consider a machine learning approach based on Gaussian process regression (GP) to position users in a distributed massive multiple-input multiple-output (MIMO) system with the uplink received signal strength (RSS) data. We focus on the scenario where noise-free RSS is available for training, but only noisy RSS is available for testing purposes. To estimate the test user locations and their 2σ error-bars, we adopt two state-of-the-art GP methods, namely, the conventional GP (CGP) and the numerical approximation GP (NaGP) methods. We find that the CGP method, which treats the noisy test RSS vectors as noise-free, provides unrealistically small 2σ error-bars on the estimated locations. To alleviate this concern, we derive the true predictive distribution for the test user locations and then employ the NaGP method to numerically approximate it as a Gaussian with the same first and second order moments. We also derive a Bayesian Cramer-Rao lower bound (BCRLB) on the achievable root- mean-squared-error (RMSE) performance of the two GP methods. Simulation studies reveal that: (i) the NaGP method indeed provides realistic 2σ error-bars on the estimated locations, (ii) operation in massive MIMO regime improves the RMSE performance, and (iii) the achieved RMSE performances are very close to the derived BCRLB.
Organotransition-Metal Metallacarboranes. 37. Paramagnetic Iron-Cobalt and Dicobalt Triple-Decker Sandwich Complexes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganotransition-Metal Metallacarboranes. 37. Paramagnetic Iron-Cobalt and Dicobalt Triple-Decker Sandwich ComplexesMartin Stephan, Peter Mueller, Ulrich Zenneck, Hans Pritzkow, Walter Siebert, and Russell N. GrimesCite this: Inorg. Chem. 1995, 34, 8, 2058–2067Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ic00112a018https://doi.org/10.1021/ic00112a018research-articleACS PublicationsRequest reuse permissionsArticle Views394Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir (2013)

African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.
Interstitial fluid flow in cancer: implications for disease progression and treatment (2014)

As cancer progresses, a dynamic microenvironment develops that creates and responds to cellular and biophysical cues. Increased intratumoral pressure and corresponding increases in interstitial flow from the tumor bulk to the healthy stroma is an observational hallmark of progressing cancers. Until recently, the role of interstitial flow was thought to be mostly passive in the transport and dissemination of cancer cells to metastatic sites. With research spanning the past decade, we have seen that interstitial flow has a promigratory effect on cancer cell invasion in multiple cancer types. This invasion is one mechanism by which cancers can resist therapeutics and recur, but the role of interstitial flow in cancer therapy is limited to the understanding of transport of therapeutics. Here we outline the current understanding of the role of interstitial flow in cancer and the tumor microenvironment through cancer progression and therapy. We also discuss the current role of fluid flow in the treatment of cancer, including drug transport and therapeutic strategies. By stating the current understanding of interstitial flow in cancer progression, we can begin exploring its role in therapeutic failure and treatment resistance.
An adaptive analog noise-predictive decision-feedback equalizer (2002)

This paper describes an adaptive analog noise-predictive decision-feedback equalizer (NPDFE). It consists of an analog finite-impulse response (FIR) forward equalizer (FE), a recursive analog equalizer for noise prediction, and a decision-feedback equalizer (DFE) that uses erasure. All three analog equalizers are adaptive. Area and power are saved by using analog rather than digital equalizers because a highspeed ADC is not required and the analog equalizers used in this prototype are smaller than their digital counterparts. To demonstrate the feasibility of our proposed NPDFE, the prototype was designed for use in a disk-drive read channel.
Catheterization Technique for Laser Photoahlation of Atrioventricular Conduction from the Aortic Root in Dogs (1993)

A simple catheterization technique for producing suppression or block of atrioventricular (AV) conduction in dogs by neodymium:YAG (Nd:YAG) laser photocoagulation from the aortic root is described. In 14 canines, electrode catheters were percutaneously advanced to the high right atrium, to the His bundle area at the tricuspid valve (right His [RH]), and the noncoronary cusp of the aortic valve (left His [LH]). A 400 microns optical fiber was fed into the lumen of the LH catheter. Continuous wave Nd:YAG lasing at lambda = 1,064 nm at 15-20 watts was performed at the site of the largest recorded LH deflection, opposite to the RH catheter, until complete AV block (CAVB, group I, eight dogs) or persistent A-H prolongation (AHPr, group II, four dogs) occurred; in two animals, laser photoablation was unsuccessful. CAVB and AHPr were achieved in < 140 seconds of lasing. Mean lasing time was 51 +/- 41 seconds, total energy delivered, 776 +/- 601 J. There were no complications. Dogs were followed for up to 120 days. In group I, 6/6 dogs followed for at least 1 week continued to have CAVB (three AV nodal, five infra-His). In group II, 1/4 dog progressed to infra-His CAVB; 3/4 had depressed AV nodal function. AV block was not reversed by isoproterenol. Aortic root angiograms revealed intact valve function in all. Histology showed various degrees of damage and repair of AV junctional tissue. There were no valvular perforations. Transcatheter Nd:YAG laser photocoagulation of the AV junction from the aortic root is a fast, simple, and safe method for creating AV conduction block in dogs.
The Gosudar and His Covert Court: Sistema, Autocracy, and Russia's Inability to Democratize (2021)

Any question about Russian President Vladimir Putin’s style of rule can be answered by examining both Russia’s past as well as the informal governmental conventions that have historically prevailed. The purpose of this article is to juxtapose the theses of two essential academics: the late historian Richard Pipes’s verdict on Russian autocracy in Russian Conservatism and Its Critics: A Study in Political Culture (2005) and the concept of sistema, authored by political sociologist Alena Ledeneva in Can Russia Modernise? Sistema, Power Networks and Informal Governance (2013). “Why can’t Russia democratize?” is an enduring question. This article will provide a thorough analysis of each individual work, and conjoin the relevant concepts presented in either title to find a possible answer to this question. The examined work of Richard Pipes will best illustrate the relevant themes of Russian history, even with details one might normally surmise as minute, such as Russia’s geography and the question of property rights. Sistema is introduced by Alena Ledeneva as an informal governmental structure which heavily dictates the customs of ruling administrations. The conclusion that this article hopes to illustrate by bridging the theories presented in the two aforementioned titles is that Russia’s inability to democratize is the consequence of both its history and the underhanded structure of its current state, which has endured throughout all forms of government — past and present alike.
Modular mixing in plasmonic metal oxide nanocrystal gels with thermoreversible links (2022)

Gelation offers a powerful strategy to assemble plasmonic nanocrystal networks incorporating both distinctive optical properties of constituent building blocks and customizable collective properties. Beyond what a single-component assembly can offer, characteristics of nanocrystal networks can be tuned in a broader range when two or more components are intimately combined. Here, we demonstrate mixed nanocrystal gel networks using thermoresponsive metal-terpyridine links that enable rapid gel assembly and disassembly with thermal cycling. Plasmonic indium oxide nanocrystals with different sizes, doping concentrations, and shapes are reliably intermixed in linked gel assemblies, exhibiting collective infrared absorption that reflects the contributions of each component while also deviating systematically from a linear combination of the spectra for single-component gels. We extend a many-bodied, mutual polarization method to simulate the optical response of mixed nanocrystal gels, reproducing the experimental trends with no free parameters and revealing that spectral deviations originate from cross-coupling between nanocrystals with distinct plasmonic properties. Our thermoreversible linking strategy directs the assembly of mixed nanocrystal gels with continuously tunable far- and near-field optical properties that are distinct from those of the building blocks or mixed close-packed structures.
Peripheral blood of AIDS patients contains cells capable of providing accessory function for the natural killer cell-mediated, lysis of herpes simplex virus-infected targets despite low interferon-alpha production. (1993)

We have previously demonstrated that in vitro production of interferon-alpha (IFN-alpha) in response to herpes simplex virus (HSV) by peripheral blood mononuclear cells PBMCs from patients infected with the human immunodeficiency virus (HIV-1) decreases dramatically with disease progression, with extremely low levels of IFN-alpha preceding and predictive of opportunistic infections. Natural killer (NK) lysis, however, was found to decay later in disease and often was within normal limits even when IFN-alpha production was severely compromised. The NK lysis of HSV-infected fibroblasts (HSV-FS) is dependent on an HLA-DR+ accessory cell (AC) population that shares the phenotype of the predominant IFN-alpha-producing cell (IPC) population. To determine whether there is a correlation between AC activity and IFN-alpha production in these patients, we tested the ability of PBMCs from AIDS patients to provide AC help to NK cells from heterologous donors. While NK cells were highly sensitive to gamma irradiation, AC activity was relatively radioresistant. Therefore, NK cells from healthy donors were depleted of HLA-DR+ ACs and added to irradiated PBMCs from either healthy or AIDS donors to test for the function of ACs in the irradiated populations. Irradiated cells from AIDS patients were found to provide normal AC activity despite decreased IFN-alpha production in the majority of the patients. We failed to observe NK augmenting activity in supernatants of irradiated PBMCs from IFN-deficient patients that had been stimulated with HSV-FS.(ABSTRACT TRUNCATED AT 250 WORDS)
Floating gate EEPROM as EOS indicators during wafer-level GMR processing (2001)

Potentially damaging charging currents and voltages in wafer-level giant magnetoresistance (GMR) plasma processing tools have been measured using floating gate EEPROM (FG-EEPROM) monitor wafers. Although FG-EEPROM monitors have been used as semiconductor process monitors, this report demonstrates their use in electrostatic discharge (ESD)-sensitive GMR head production. Use of FG-EEPROM monitors allows quantification of plasma-induced EOS voltages and currents, and can be used in optimizing process tool EOS performance, as is demonstrated in a case study on an ion mill.
A Myriad Filter Detector for UWB Multiuser Communication (2008)

UWB multiple access interference is known to be non-Gaussian. Work has attempted to design better UWB detectors by approximating the distribution of the multiple access interference by a non-Gaussian noise model. In this paper, a non-linear detector is proposed, which is inspired by the empirical finding that the UWB multiple access interference can be better modeled by a symmetric-alpha-stable distribution than the Laplacian, generalized Gaussian, Cauchy and Gaussian distributions. The new detector which is adaptive to the current interference-plus-noise condition is found to outperform many other non-Gaussian (non-linear) detectors proposed for UWB multiuser communication.
Strain-Release-Driven Homologation of Boronic Esters: Application to the Modular Synthesis of Azetidines (2019)

Azetidines are important motifs in medicinal chemistry, but there are a limited number of methods for their synthesis. Herein, we present a new method for their modular construction by exploiting the high ring strain associated with azabicyclo[1.1.0]butane. Generation of azabicyclo[1.1.0]butyl lithium followed by its trapping with a boronic ester gives an intermediate boronate complex which, upon N-protonation with acetic acid, undergoes 1,2-migration with cleavage of the central C-N bond to relieve ring strain. The methodology is applicable to primary, secondary, tertiary, aryl, and alkenyl boronic esters and occurs with complete stereospecificity. The homologated azetidinyl boronic esters can be further functionalized through reaction of the N-H azetidine, and through transformation of the boronic ester. The methodology was applied to a short, stereoselective synthesis of the azetidine-containing pharmaceutical, cobimetinib.
STUDY ON HUMAN DISEASED THYROID CELLS IN COLLAGEN GEL CULTURE (1993)

Thyroid cells from 14 normal subjects, two patients with Grave's disease, four patients with follicular adenoma and eight patients with papillary carcinoma were cultured in collagen gel. The colonies of these cells were stereoscopically observed and their morphological characteristics were studied with regard to relation with pathological findings of mother tumor, extra-capsular invasion and metastatic potential. For normal thyroid, Grave's disease and follicular adenoma (except for one case), their own characteristic branching type colonies were found. For papillary carcinoma, both branching type and spheroid type of colonies were observed. The ratio of branching type/spheroid type varied individually in the patients with papillary carcinoma. However, the spheroid type was found to trend to be predominant in patients with extra-capsular invasion and/or lymph node metastasis. This means that the observation of spheroid type colonies in collagen gel is suggestive of risk of extra-capsular invasion or lymph node metastasis. From the obtained results, it seemed possible to diagnose poorly-differentiated cells in vitro by morphologically observing colonies of human thyroid papillary carcinoma cells developing in collagen gel.
Preparation and characterization of PVDF/alkali-treated-PVDF blend membranes (2016)

Poly(vinylidene fluoride) (PVDF) powder was treated with aqueous sodium hydroxide to obtain partially defluorinated fluoropolymers with expected properties such as improving hydrophilicity and fouling resistance. Raman spectrum and FT-IR results confirmed the existence of conjugated carbon double bonds after alkaline treatment. As the concentration increased, the degree of defluorination increased. The morphology and structure of membranes were examined. The permeation performance was investigated. The results showed that membrane's hydrophilicity increased with increase of the percentage of alkaline treated PVDF powder. Moreover, in terms of the water contact angle, it decreased from 92° to a minimum of 68°; while water up take increased from 128 to 138%. Fluxof pure water and the cleaning efficiency increased with the increase of alkaline treated PVDF powder. The fouling potential also decreased with the increase of the percentage of alkaline treated PVDF powder. The reason that makes blending PVDF show different characteristics because of partial defluorination, which led the formation of conjugated C = C bonds and the inclusion of oxygen functionalities. The polyene structure followed by hydroxide attack to yield hydroxyl and carbonyl groups. Therefore, the hydrophilicity of blending membrane was improved. The SEM and porosity measurements showed that no obvious variations of the pore dimensions and structures for blend membranes were observed. Mechanical tests suggest that the high content of the alkaline treated PVDF result in membranes with less tolerance of tensile stress and higher brittleness. TGA results exhibited that the blend of alkaline treated PVDF did not change membrane thermal stability.
Optical switching due to whispering gallery modes in dielectric microspheres coated by a Kerr material (2003)

We numerically evaluated the optical responses of a nonlinear microsphere put on prisms, i.e. in prism-coupling geometry where the incident light excites the WGM through near-field coupling. As numerical calculations, we employed the finite-difference time-domain method taking into account Kerr nonlinearity. The sphere was coated by a Kerr material with 160 nm thick. The third-order nonlinear susceptibility of the Kerr material chi(3) was assumed to be 7 x 10(-14)[m(2) V(-2)]. The diameter of the sphere was assumed to be 1 micro m. The numerical results have shown that the control and/or the signal lights can induce the optical switching-like variation in the reflectance. Such a nonlinear response of the sphere has been interpreted by the variation in the dielectric constant of the sphere due to a Kerr nonlinearity.
Investigation of Copaifera Genus as a New Source of Antimycobaterial Agents (2020)

Among the assayed oleoresins and plant extracts, the <i>Copaifera langsdorffii</i>, <i>Copaifera duckei</i>, <i>Copaifera reticulata</i> and <i>Copaifera trapezifolia</i> oleoresins provided the lowest MIC values against some of the tested strains. The combination of <i>Copaifera</i> spp. samples with isoniazid did not evidence any synergistic action. Some <i>Copaifera</i> spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.
Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling (2021)

Tissue engineering combines principles of engineering and biology to generate living tissue equivalents for drug testing, disease modeling, and regenerative medicine. As techniques for reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) and subsequently differentiating them into cardiomyocytes and other cardiac cells have become increasingly efficient, progress toward the development of engineered human cardiac muscle patch (hCMP) and heart tissue analogs has accelerated. A few pilot clinical studies in patients with post-infarction LV remodeling have been already approved. Conventional methods for hCMP fabrication include suspending cells within scaffolds, consisting of biocompatible materials, or growing two-dimensional sheets that can be stacked to form multilayered constructs. More recently, advanced technologies, such as micropatterning and three-dimensional bioprinting, have enabled fabrication of hCMP architectures at unprecedented spatiotemporal resolution. However, the studies working on various hCMP-based strategies for <i>in vivo</i> tissue repair face several major obstacles, including the inadequate scalability for clinical applications, poor integration and engraftment rate, and the lack of functional vasculature. Here, we review many of the recent advancements and key concerns in cardiac tissue engineering, focusing primarily on the production of hCMPs at clinical/industrial scales that are suitable for administration to patients with myocardial disease. The wide variety of cardiac cell types and sources that are applicable to hCMP biomanufacturing are elaborated. Finally, some of the key challenges remaining in the field and potential future directions to address these obstacles are discussed.
A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia (2011)

Current evidence supports a major role for inherited factors in determining bronchopulmonary dysplasia (BPD) susceptibility. The Toll-like receptor (TLR) family of proteins maintain pulmonary homeostasis in the developing lung by aiding pathogen recognition and clearance, regulating inflammation, and facilitating reparative tissue growth. We hypothesized that sequence variation in the TLR pathway genes would alter the susceptibility/severity of BPD in preterm infants. Very low birth-weight infants were recruited prospectively in a multi-center study involving collection of blood samples and clinical information. Nine TLR pathway single-nucleotide polymorphisms were genotyped using a multiplexed single-base extension assay. BPD outcomes were compared among infants with and without the variant allele using Chi-square or Fisher's exact tests. In our cohort (n = 289), 66 (23.6%) infants developed BPD, out of which 32 (11.2%) developed severe BPD. The TLR5 (g.1174C > T) variant was associated with BPD (P = 0.03) and severe BPD (P = 0.004). The TIRAP (g.2054C > T) variant was associated with BPD (P = 0.04). Infants heterozygous for the X-linked IRAK1 (g.6435T > C) variant had a lower incidence of BPD compared to infants homozygous for either the reference or variant allele (P = 0.03). In regression models that controlled for potential epidemiological confounders, the TIRAP variant was associated with BPD, and the TLR5 variant was associated with severe BPD. Our data support the hypothesis that aberrant pathogen recognition in premature infants arising from TLR pathway genetic variation can contribute to BPD pathogenesis.