gebhart/patrepeval huggingface dataset:
Nailfold capillaroscopy in SSc: innocent bystander or promising biomarker for novel severe organ involvement/progression? (2022)

Our results suggest that NVC may be a promising biomarker in SSc, certainly warranting further investigation. Despite the participation of tertiary centres, which follow their patients in a standardized way, we were underpowered to detect associations with infrequent severe organ involvement/progression.
Sorting Competition with Membrane-permeable Peptides in Intact Epithelial Cells Revealed Discrimination of Transmembrane Proteins Not Only at the trans-Golgi Network but Also at Pre-Golgi Stages (2004)

Transmembrane proteins destined to the basolateral cell surface of epithelial cells contain in their cytosolic domain at least two classes of sorting signals: one class promotes exit from the endoplasmic reticulum (ER) and transport to the Golgi complex, and the other class operates at the trans-Golgi network (TGN) specifying segregation into basolateral exocytic pathways. Both kinds of addressing motifs are quite diverse among different proteins. It is unclear to what extent this feature reflects alternative decoding mechanisms or variations in motifs recognized by the same sorting factor. Here we applied a novel strategy based on permeable peptide technology and temperature-sensitive model proteins to study competition between cytosolic sorting motifs in the context of mammalian living cells. We used the transduction domain of HIV-1 Tat protein to make a membrane-permeable peptide of the cytosolic tail of GtsO45, which contains a well characterized ER exit di-acidic (DIE) motif and a tyrosine-based basolateral sorting signal (YTDI). This peptide added to the media inhibited transport of GtsO45 from both ER-to-Golgi and TGN-to-basolateral cell surface in transfected Madin-Darby canine kidney cells. Instead, it did not affect the exocytic trafficking of a GtsO45-derived chimeric protein bearing 30 juxtamembrane residues from the cytosolic domain of the epidermal growth factor receptor that contains a variant ER exit motif (ERE) and an unconventional proline-based basolateral sorting signal. These results not only proved the feasibility of competing for sorting events in intact cells but also showed that distinct plasma membrane proteins can be discriminated at pre-TGN stages, and that basolateral sorting involves different recognition elements for tyrosine-based motifs and an unconventional basolateral motif.
Resistant coagulase negative staphylococci from clinical samples. (1991)

Antibiotic susceptibility testing against 17 antibiotics was done on 96 strains of various species of coagulase negative staphylococci by Stokes method. Hundred per cent sensitivity was found against vancomycin and cefotaxime and about 90 per cent against ciprofloxacin, clavulanate potentiated amoxycillin, cloxacillin and clindamycin. Strains showed highest resistance against cotrimoxazole (77.08%) and tetracycline (64.59%). Clavulanate potentiated amoxycillin was found to be highly active against penicillin, ampicillin and amoxycillin resistant organisms. The results highlight the importance of antibiotic resistance typing among coagulase negative staphylococci species which are increasingly being reported from serious clinical infections making empiric therapy and selection of antibiotics difficult in these infections.
Prediction of pseudophakic anterior chamber depth with the newer IOL calculation formulas (1992)

Five methods for predicting pseudophakic anterior chamber depth (ACD) by five previously described intraocular lens power calculation formulas (Binkhorst II, Lepper and Trier, Holladay et al., Sanders-Retzlaff-Kraff (SRK/T), Olsen et al.) were evaluated in a series of 640 patients with a posterior chamber lens implant. Significant differences in formula performance were found in unusually short and long eyes. High errors were found in long eyes with the Lepper and Trier formula, the Holladay formula, and the SRK/T method. The highest accuracy was found with the Binkhorst formula and our previously described linear regression formula which expresses the pseudophakic ACD as a function of the average pseudophakic ACD for a given lens style, the preoperative ACD, and the axial length. The use of the preoperative ACD in combination with the axial length for the prediction of the pseudophakic ACD can therefore be expected to improve the accuracy of IOL power calculation.
Re: Nanoparticle-Enabled Selective Destruction of Prostate Tumor Using MRI-Guided Focal Photothermal Therapy (2016)

No AccessJournal of UrologyInvestigative Urology1 Dec 2016Re: Nanoparticle-Enabled Selective Destruction of Prostate Tumor Using MRI-Guided Focal Photothermal Therapy Samir S. TanejaMD Samir S. TanejaSamir S. Taneja More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.09.063AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Nanoparticle-Enabled Selective Destruction of Prostate Tumor Using MRI-Guided Focal Photothermal Therapy." The Journal of Urology, 196(6), p. 1819 © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 196Issue 6December 2016Page: 1819 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samir S. Taneja More articles by this author Expand All Advertisement PDF downloadLoading ...
Highly piezoelectric co-doped AlN thin films for wideband FBAR applications (2015)

We report piezoelectric materials composed of charge-compensated co-doped (Mg, β)(x)Al(1-x)N (β = Zr or Hf) thin films. The effect of the dopant element into AlN on the crystal structure, and piezoelectric properties of co-doped AlN was determined on the basis of a first-principles calculation, and the theoretical piezoelectric properties were confirmed by experimentally depositing thin films of magnesium (Mg) and zirconium (Zr) co-doped AlN (Mg-Zr-doped AlN). The Mg-Zrdoped AlN thin films were prepared on Si (100) substrates by using a triple-radio-frequency magnetron reactive co-sputtering system. The crystal structures and piezoelectric coefficients (d33) were investigated as a function of the concentrations, which were measured by X-ray diffraction and a piezometer. The results show that the d33 of Mg-Zr-doped AlN at total Mg and Zr concentrations (both expressed as β) of 0.35 was 280% larger than that of pure AlN. The experimentally measured parameter of the crystal structure and d33 of Mg-Zr-doped AlN (plotted as functions of total Mg and Zr concentrations) were in very close agreement with the corresponding values obtained by the first-principle calculations. Thin film bulk acoustic wave resonators (FBAR) employing (Mg,Zr)0.13Al0.87N and (Mg, Hf)0.13 Al0.87N as a piezoelectric thin film were fabricated, and their resonant characteristics were evaluated. The measured electromechanical coupling coefficient increased from 7.1% for pure AlN to 8.5% for Mg-Zr-doped AlN and 10.0% for Mg- Hf-doped AlN. These results indicate that co-doped (Mg, β)(x)Al(1-x)N (β = Zr or Hf) films have potential as piezoelectric thin films for wideband RF applications.
Theoretical Studies in Nondestructive Evaluation (NDE) (1985)

Abstract : A previously developed technique has been use to describe the discrete scattering of scalar waves from defects on a regular simple cubic lattice. The method makes no assumption about the symmetry of the scatterers and therefore can be applied to inhomogeneities of arbitrary shape. The only limitation of the technique is the maximum number of defects one can use to specify the scatter, which in turn is determined by limitations in computation time. The multiple scattering model proposed by Foldy and later extended by Lax was implemented by West and Shlesinger as a means of evaluating the distribution of grains in polycrystalline materials. If the material consists of grains such that the wavelength is much larger than the grain size then the density of scatterers probed by the acoustic wave is unchanged as the frequency is increased, provided that one remains in the Rayleigh scattering domain. If one is in the scattering domain where the wavelength is less than or equal to the grain size, then the density of scatterers increases no more rapidly than the square of the linear scale (a-squared) rather than as its cube as it would in the usual situation. This implies that the density of scatterers is a fractal in the stochastic scattering domain. Note also that the surface of a grain can have many scales and may in part be responsible for the fractal behavior observed in the phenomenological expression. Keywords: Scattering theory, The Fractal Dimension of Ultrasonic Scatters.
Synthesis and characterization of Mo(nor)4 (nor = 1-norbornyl) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of Mo(nor)4 (nor = 1-norbornyl)Richard M. Kolodziej, Richard R. Schrock, and William M. DavisCite this: Inorg. Chem. 1988, 27, 18, 3253–3255Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ic00291a047https://doi.org/10.1021/ic00291a047research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Kava in generalized anxiety disorder: three placebo-controlled trials (2006)

In this study, we evaluated the efficacy and safety of kava kava (Piper methysticum) in generalized anxiety disorder. Data were analyzed from three randomized, double-blind, placebo-controlled trials of kava, including one study with an active comparator (venlafaxine), in adult outpatients with DSM-IV generalized anxiety disorder. The pooled sample (n=64) included the following number of participants: kava, n=28; placebo, n=30; and venlafaxine, n=6. Given the comparability of the study designs, the data comparing kava and placebo were then pooled for further efficacy and safety analyses. No significant differences were observed between the treatment groups in any of the trials. In the pooled analyses, no effects were found for kava, while a significant effect in favor of placebo was observed in participants with higher anxiety at baseline. No evidence of hepatotoxicity was found with kava, and all of the treatments were well tolerated. Findings from these three controlled trials do not support the use of kava in DSM-IV generalized anxiety disorder.
A 16-bit 2.0-ps Resolution Two-Step TDC in 0.18-<inline-formula> <tex-math notation="LaTeX">$\mu$ </tex-math> </inline-formula>m CMOS Utilizing Pulse-Shrinking Fine Stage With Built-In Coarse Gain Calibration (2018)

This paper proposes a time-to-digital converter (TDC) that achieves wide input range and fine time resolution at the same time. The proposed TDC utilizes pulse-shrinking (PS) scheme in the second stage for a fine resolution and two-step (TS) architecture for a wide range. The proposed PS TDC prevents an undesirable nonuniform shrinking rate issue in the conventional PS TDCs by utilizing a built-in offset pulse and an offset pulsewidth detection schemes. With several techniques, including a built-in coarse gain calibration mechanism, the proposed TS architecture overcomes a nonlinearity due to the signal propagation and gain mismatch between coarse and fine stages. The simulation results of the TDC implemented in a 0.18-μm standard CMOS technology demonstrate 2.0-ps resolution and 16-bit range that corresponds to ~130-ns input time interval with 0.08-mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> area. It operates at 3.3 MS/s with 18.0 mW from 1.8-V supply and achieves 1.44-ps single-shot precision.
Cytotoxicity of water-soluble fullerene in vascular endothelial cells (2006)

Nanoscale materials are presently under development for diagnostic (nanomedicine) and electronic purposes. In contrast to the potential benefits of nanotechnology, the effects of nanomaterials on human health are poorly understood. Nanomaterials are known to translocate into the circulation and could thus directly affect vascular endothelial cells (ECs), causing vascular injury that might be responsible for the development of atherosclerosis. To explore the direct effects of nanomaterials on endothelial toxicity, human umbilical vein ECs were treated with 1-100 microg/ml hydroxyl fullerene [C60(OH)24; mean diameter, 7.1 +/- 2.4 nm] for 24 h. C60(OH)24 induced cytotoxic morphological changes such as cytosolic vacuole formation and decreased cell density in a dose-dependent manner. Lactate dehydrogenase assay revealed that a maximal dose of C60(OH)24 (100 microg/ml) induced cytotoxic injury. Proliferation assay also showed that a maximal dose of C60(OH)24 inhibited EC growth. C60(OH)24 did not seem to induce apoptosis but caused the accumulation of polyubiquitinated proteins and facilitated autophagic cell death. Formation of autophagosomes was confirmed on the basis of Western blot analysis using a specific marker, light chain 3 antibody, and electron microscopy. Chronic treatment with low-dose C60(OH)24 (10 microg/ml for 8 days) inhibited cell attachment and delayed EC growth. In the present study, we have examined, for the first time, the toxicity of water-soluble fullerenes to ECs. Although fullerenes changed morphology in a dose-dependent manner, only maximal doses of fullerenes caused cytotoxic injury and/or death and inhibited cell growth. EC death seemed to be caused by activation of ubiquitin-autophagy cell death pathways. Although exposure to nanomaterials appears to represent a risk for cardiovascular disorders, further in vivo validations are necessary.
Film extrusion and film weldability of poly(lactic acid) plasticized with triacetine and tributyl citrate (2003)

Abstract Film extrusion and welding of biodegradable polymer films are important processes that must be considered in the development of compostable packaging materials. Film extrusion of poly(lactic acid) (PLA) has proved to be rather difficult because of its brittleness, but the flexibility of PLA can be improved by incorporation of a plasticizer in the material. PLA was plasticized with triacetine (TAc) and tributyl citrate (TbC). The blended materials and neat PLA were film extruded and the films were welded with constant heat (CH) welding. The films were analyzed by means of gas chromatography (GC), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), contact angle measurements, and tensile testing. Storage of the plasticized films resulted in an increased crystallinity and changes in the film properties, rendering CH welding difficult. The welding process had no influence on thermal properties, such as cold crystallization temperature, melting temperature, crystallization temperature, and degree of crystallinity, of neat PLA but caused significant changes in the crystallinity of the plasticized materials. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 3239–3247, 2003
Trna: Structure, Biosynthesis, and Function (1995)

Transfer RNA after four decades tRNA: discovery, early work and total synthesis of tRNA genes Structure and expression of prokaryotic tRNA genes Transcription of eukaryotic tRNA genes tRNA processing nucleases Recent studies of RNase P Splicing of tRNA precursors Primary, secondary and tertiary structure of tRNAs Organellar tRNAs: biosynthesis and function tRNA-like structures in plant viral RNAs Biosynthesis and function of modified nucleosides Modified nucleosides and codon recognition tRNA sequences and variations in the genetic code Aminoacyl-tRNA synthetases: occurrence, structure and function Bacterial aminoacyl-tRNA synthetases: genes and regulation of expression The tRNA identity problem: past, present and future Small RNA oligonucleotide substrates for specific aminoacylations tRNA discrimination in aminoacylation Recognition in the glutamine tRNA system: from structure to function The aspartic acid tRNA system: recognition by a class II aminoacyl-tRNA synthetase Recognition of aminoacyl-tRNAs by protein elongatin factors tRNA on the ribosome: a waggle theory Discontinuous triplet decoding with or without re-pairing by peptidyl tRNA Translational suppression: when two wrongs do make a right Initiator tRNAs and initiation of protein synthesis The selenocysteine-inserting tRNA species: structure and function Glutamyl-tRNA as an intermediate in glutamate conversions
Enhancement of Image Segmentation osing Automatic Histogram Thresholding (2015)

This study is focused on histogram thresholding methods automatically. In computer vision, Image segmentation is an initial and vital step in a series of processes aimed at overall image understanding. In other words Segmentation refers to the process of partitioning a digital image into the multiple segments (set of pixels as known as super pixels). Two very simple image segmentation techniques that are based on the gray level histogram of an image are Thresholding and Clustering. Thresholding method is widely used for image segmentation approach. It is useful in discriminating foreground from the background. By selecting an adequate threshold value T, or automatically computing threshold value T, the gray level image can be converted in to binary image. Several methods are there to find the threshold automatically for image segmentation. Some of the methods like Otsu, Kapur, Triangle, Iterative and also manually threshold is calculated for different type of images like X-ray computed tomography (CT-Scan), magnetic resonance imaging (MRI), synthetic aperture radar (SAR), Ultrasound image were explained and the results are presented to show the validity of the methods.
Patch-based adaptive tracking using spatial and appearance information (2008)

We present a patch-based tracking algorithm in which both appearance and spatial information are taken into account for target localization. We decompose a target into several patches based on appearance similarity and spatial distribution. Each patch has its distinctive appearance and spatial distribution. Appearance information is described by kernels which are non-parametric; while spatial information is represented by spatial Gaussians. The overall motion is estimated by mean shift algorithm. The motion is refined based on the likelihood images computed using pixel classification. The proposed tracker provides better position and likelihood images.
Numerical Simulation and Stability Analysis of Thin Flexible Micro Film for Thermotunneling Application (2012)

Combined thermionic emission and tunneling of hot electrons (thermo-tunneling) has emerged as a potential new solidstate cooling technology. Practical implementation of thermo-tunneling, however, requires the formation of a nanometer-sized gap spanning macroscopically significant surfaces. Thermo-tunneling is a term used to describe combined emission of hot electrons (thermionic emission) and tunneling of electrons through a narrow potential barrier between two surfaces (field emission). Thermo-tunneling of hot electrons across a few-nanometer gap has application to vacuum electronics, flat panel displays, and holds great potential in thermo-electric cooling and energy generation. Development of new thermo-tunneling applications requires creation of a stable nanometer gap between two surfaces. This presentation is focused on our effort to investigate the stability of the the thin flexible structure under electrostatic and lorenz forces opposing each other. In this presentation, we report the result of numerical simulation with some mathematical simplifications. The mathematical model used for the numerical simulation is well studied in the literature. Using forth-order partial differential beam equation, we studied the steady state solutions of the thermo-tunneling beam model using Galerkin method. Essential output parameters of the model include a central contact area measured by its length (delta) and the thermo-tunneling current. Both parameters are determined as a function of the externally applied external potential and magnetic field. Numerical solutions of the model show two possible operating modes: (1) symmetric deformation with negligibly small current; and (2) asymmetric mode where the B-field controls the current and contact area. Under practical values for the externally applied magnetic and electric fields, it has been shown that the second mode is only possible for electrode with very low work functions, e.g. below 0.5 eV. Therefore, novel materials such as Diamond-like carbon films are likely to be essential in thermo-tunneling applications.
Single Photon Ionization and Chemical Ionization Combined Ion Source Based on a Vacuum Ultraviolet Lamp for Orthogonal Acceleration Time-of-Flight Mass Spectrometry (2011)

A novel combined ion source based on a vacuum ultraviolet (VUV) lamp with both single photon ionization (SPI) and chemical ionization (CI) capabilities has been developed for an orthogonal acceleration time-of-flight mass spectrometer (oaTOFMS). The SPI was accomplished using a commercial 10.6 eV krypton discharge lamp with a photon flux of about 10(11) photons s(-1), while the CI was achieved through ion-molecule reactions with O(2)(+) reactant ions generated by photoelectron ionization at medium vacuum pressure (MVP). To achieve high ionization efficiency, the ion source pressure was elevated to 0.3 mbar and the photoionization length was extended to 36 mm. As a result, limits of detection (LODs) down to 3, 4, and 6 ppbv were obtained for benzene, toluene, and p-xylene in MVP-SPI mode, and values of 8 and 10 ppbv were obtained for toluene and chloroform, respectively, in SPI-CI mode. As it is feasible to switch between MVP-SPI mode and SPI-CI mode rapidly, this system is capable of monitoring complex organic mixtures with a wide range of ionization energies (IEs). The analytical capacity of this system was demonstrated by measuring dehydrogenation products of long-chain paraffins to olefins through direct capillary sampling and drinking water disinfection byproducts from chlorine through a membrane interface.
Gram-negative bacteria can induce contact lens related acute red eye (CLARE) responses. (1996)

This study draws attention to the possible contribution of contaminated lenses and storage cases in contact lens related acute inflammation and specifically implicates gram-negative bacteria, in particular Pseudomonas spp. and Serratia spp., in the inducement of acute inflammatory reactions such as CLARE.