gebhart/patrepeval huggingface dataset:
A new automatic MF generator (AMFG) for general 3D type-ii fuzzy in the polar frame (2014)

There are myriad membership functions that used in fuzzy realm. These methods are used to initially represent the distribution of the pattern data. This paper deal with a new generation of fuzzy membership functions in the new form of representation. In this paper, an automatic GT2 FMF generator is introduced in the frame of polar system. First, the IT2 FMF algorithm introduced, and then GT2 MF is described. Cubic Smoothing Spline (CSS) is used for generating the upper and lower membership function. The Three Dimensional Membership Functions (3DMFs) in upper and lower (3DMFu and 3DMF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</sub> ) are tested from the tuning the parameters of a cubic smoothing Spline. The parameters of Compactness and Smoothness are employed for tuning the 3DMFs. Some of the desirable properties of this method are described and capability of proposed method illustrated with an application in Automatic Asphalt pavement distress detection systems.
Design and analysis of a replicated server architecture for supporting IP-Host mobility (1998)

Mobility support in IP networks requires servers to forward packets to mobile hosts and to maintain information pertaining to a mobile host's location in the network. In the mobile Internet Protocol (mobile-IP), location and packet forwarding functions are provided by servers referred to as home agents. These home agents may become the bottleneck when there are a large number of mobile hosts in the network. In this paper, we consider the design and analysis of a replicated server architecture in which multiple home agents are used to provide mobility support. In order to minimize the delay across the home agents, one of the key aspects is the design of load balancing schemes in which a home agent may transfer the control of a mobile host to another home agent in the same network. The methods for triggering the transfer and the policy for selecting the next home agent define various load balancing schemes which have different performance characteristics. In this paper, we design a protocol that forms the building block for implementing such load balancing schemes, and we then study the performance characteristics of random, round-robin, and join the shortest queue (JSQ) selection policies, and timer-, counter- and threshold-based transfer policies.
Oral antihyperglycemic therapy for type 2 diabetes mellitus (2005)

Diabetes mellitus is a chronic disease that is growing in prevalence worldwide. Pharmacologic therapy is often necessary to achieve optimal glycemic control in the management of diabetes. Orally administered antihyperglycemic agents (OHAs) can be used either alone or in combination with other OHAs or insulin. The number of available OHAs has increased significantly in the last decade, which translates into more therapeutic options and complex decision-making for physicians. This review article is designed to help with these decisions. We review the mechanism of action, efficacy and side effects of the different classes of OHAs (alpha-glucosidase inhibitors, biguanides, insulin secretagogues, insulin sensitizers and intestinal lipase inhibitor) and discuss the current recommendations for their use.
Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons (1988)

Epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) are potent mitogenic proteins capable of inducing cell division in a wide variety of cell types. In addition to their mitogenic properties, both proteins have recently been shown to enhance survival and process outgrowth from neurons of central nervous system origin. The full spectrum of neuronal subtypes responding to these factors has not been elucidated. In the present study, EGF was found to enhance survival and process outgrowth of primary cultures of cerebellar neurons of neonatal rat brain. This effect was dose-dependent and was observed with EGF concentrations as low as 100 pg/ml. In marked contrast, bFGF was ineffective in enhancing survival or neurite elongation from cerebellar neurons when tested in the range of 0.1 to 10.0 ng/ml. However, within this concentration range, bFGF did prove effective in stimulating an increase in [3H]thymidine incorporation into primary cultures of cerebellar astrocytes, demonstrating that bFGF was active and that cells in the cerebellum do respond to bFGF. These results suggest that EGF or an EGF-like peptide may act as a neurite elongation and maintenance factor for cerebellar neurons. EGF has now been shown to support striatal, cortical, and cerebellar neurons, suggesting that this factor may have trophic activity throughout the central nervous system. bFGF, in contrast, appears to exert its effects on limited populations of neurons.
Microbiota intestinal y salud: de los probióticos al trasplante fecal (2018)

Trabajo presentado en la XI Jornada Cientifica-Taller sobre Bebidas Fermentadas y Salud: Alimentos y bebidas fermentadas: ?podemos interferir con los mecanismos moleculares del envejecimiento?, celebrada en Madrid (Espana) del 21 al 22 de junio de 2018
Inline NMR via a Dedicated V-Shaped Sensor (2023)

Process monitoring and control require dedicated and reliable measures which reflect the status of the process under investigation. Although nuclear magnetic resonance is known to be a versatile analytical technique, it is only seldomly found in process monitoring. Single-sided nuclear magnetic resonance is one well known approach for being applied in process monitoring. The dedicated V-sensor is a recent approach that allows the inline investigation of materials in a pipe non-destructively and non-invasively. An open geometry of the radiofrequency unit is realized using a tailored coil, enabling the sensor to be applied for manifold mobile applications in in-line process monitoring. Stationary liquids were measured, and their properties were integrally quantified as the basis for successful process monitoring. The sensor, in its inline version, is presented along with its characteristics. An exemplary field of application is battery production in terms of anode slurries; thus, the first results on graphite slurries will demonstrate the added value of the sensor in process monitoring.
Automatic metadata generation & evaluation (2002)

The poster reports on a project in which we are investigating methods for breaking the human metadata-generation bottleneck that plagues Digital Libraries. The research question is whether metadata elements and values can be automatically generated from the content of educational resources, and correctly assigned to mathematics and science educational materials. Natural Language Processing and Machine Learning techniques were implemented to automatically assign values of the GEMgenerate metadata element set tofor learning resources provided by the Gateway for Education (GEM), a service that offers web access to a wide range of educational materials. In a user study, education professionals evaluated the metadata assigned to learning resources by either automatic tagging or manual assignment. Results show minimal difference in the eyes of the evaluators between automatically generated metadata and manually assigned metadata.
The development of progesterone-loaded nanofibers using pressurized gyration: A novel approach to vaginal delivery for the prevention of pre-term birth (2018)

Recent evidence has continued to support the applicability of progesterone in preventing preterm birth, hence the development of an appropriate vaginal delivery system for this drug would be of considerable interest. Here, we describe the development of progesterone-loaded bioadhesive nanofibers using pressurized gyration for potential incorporation into a vaginal insert, with a particular view to addressing the challenges of incorporating a poorly water-soluble drug into a hydrophilic nanofiber carrier. Polyethylene oxide and carboxymethyl cellulose were chosen as polymers to develop the carrier systems, based on previous evidence of their yielding mucoadhesive nanofibers using the pressurized gyration technique. The fabrication parameters such as solvent system, initial drug loading and polymer composition were varied to facilitate optimisation of fiber structure and efficiency of drug incorporation. Such studies resulted in the formation of nanofibers with satisfactory surface appearance, diameters in the region of 400 nm and loading of up to 25% progesterone. Thermal and spectroscopic analyses indicated that the drug was incorporated in a nanocrystalline state. Release from the drug-loaded fibers indicated comparable rates of progesterone dissolution to that of Cyclogest, a commercially available progesterone pessary, allowing release over a period of hours. Overall, the study has shown that pressurized gyration may produce bioadhesive progesterone-loaded nanofibers which have satisfactory loading of a poorly water-soluble drug as well as having suitable structural and release properties. The technique is also capable of producing fibers at a yield commensurate with practical applicability, hence we believe that the approach shows considerable promise for the development of progesterone dosage forms for vaginal application.
LASERS and Applications As a motivation program for high school students (2003)

In order to attract more high school students in the scientific and technical universities, we develop an "itinerary class room in laser technology". Based on laser hardware that fits within few small suitcases, a general and illustrated talk on laser basics is followed by various experiments by the students themselves
Interaction of human immunodeficiency virus with human sperm in vitro. (1988)

Transmission of human immunodeficiency virus (HIV) in semen by sexual intercourse is believed to be a major etiological factor in the spread of the disease. In order to explore the role of sperm in this transmission, cell-free HIV-1(IIIB) was coincubated with human sperm for 5 h. After incubation, unattached HIV-1 was extensively washed off the cells and the presence and location of HIV-1 in or on the sperm was determined by electron microscopic (EM) and immunofluorescence methods. Examination of sperm at the EM level showed that HIV-1 attaches to the sperm surface and enters the sperm through the intact cell membrane. Immunofluorescence studies, using polyvalent anti-HIV antibodies, demonstrated the presence of small round fluorescent particles in 5-10% of sperm heads after 5 h of incubation. A search for HIV-1 receptors (CD4 epitopes) revealed the presence of OKT4 epitopes, including OKT4A, B, D, and F on 5-10% of sperm by epifluorescence microscopy and on 10-20% of sperm by flow-cytometric analysis. These in vitro data suggest that human sperm may be the primary cellular element in the transmission of HIV by semen.
The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis (2017)

In intestinal epithelial cells (IEC), it was reported that the activation of the P2X7 receptor leads to the internalization of the glucose transporter GLUT2, which is accompanied by a reduction of IEC capacity to transport glucose. In this study, we used P2rx7 <sup>-/-</sup> mice to decipher P2X7 functions in intestinal glucose transport and to evaluate the impacts on metabolism. Immunohistochemistry analyses revealed the presence of GLUT2 at the apical domain of P2rx7 <sup>-/-</sup> jejunum enterocytes. Positron emission tomography and biodistribution studies demonstrated that glucose was more efficiently delivered to the circulation of knockout animals. These findings correlated with increase blood glucose, insulin, triglycerides and cholesterol levels. In fact, P2rx7 <sup>-/-</sup> mice had increased serum triglyceride and cholesterol levels and displayed glucose intolerance and resistance to insulin. Finally, P2rx7 <sup>-/-</sup> mice developed a hepatic steatosis characterized by a reduction of Acaca, Acacb, Fasn and Acox1 mRNA expression, as well as for ACC and FAS protein expression. Our study suggests that P2X7 could play a central role in metabolic diseases.
Multi-channel feedforward ANC system combined with noise source separation (2015)

In this paper, we examine the effectiveness of Multi-channel feedforward active noise control (ANC) system combined with noise source separation through some simulations. Multi-channel feedforward ANC system can reduce various noise such as the broad-band noise by arranging the reference microphones close to noise sources. However, the performance of ANC system deteriorates when the reference microphones cannot be arranged close to noise sources because each microphone catches undesired noise in addition to desired noise. The proposed system separates noises by using microphone arrays as reference microphones and the separated signals are used as the reference signals of the ANC system. In simulation results, the proposed system can improve the noise reduction performance in case where the ANC system uses two reference microphones and the reference microphones do not need to be arranged close to the noise sources.
(Invited) Structural Studies of Endohedral Fullerenes of the M2C2n Class (2013)

Abstract not Available.
Cooperative Regulation of p70S6 Kinase by Receptor Tyrosine Kinases and G Protein-Coupled Receptors Augments Airway Smooth Muscle Growth (2005)

We have previously demonstrated that concomitant activation of receptor tyrosine kinases and certain G protein-coupled receptors (GPCRs) can promote a synergistic increase in the rate of airway smooth muscle cell (ASM) proliferation. Here we clarify the role of p70S6 kinase (p70S6K) as an integrator of receptor tyrosine kinase and GPCR signaling that augments ASM DNA synthesis by demonstrating that specific p70S6K phosphorylation sites receive distinct regulatory input from GPCRs that promotes sustained kinase activity critical to mitogenesis. Prolonged stimulation of ASM cells with EGF and thrombin induced a greater than additive effect in levels of p70S6K phosphorylated at residue T389, whereas a significant but more modest increase in the level of T229 and T421/S424 phosphorylation was also observed. The augmenting effects of thrombin could be dissociated from p42/p44 MAPK activation, as selective inhibition of thrombin-stimulated p42/p44 failed to alter the profile of cooperative p70S6K T389 phosphorylation, p70S6K kinase activity, or ASM [3H]thymidine incorporation. Thrombin stimulated a sustained increase in the level of Akt phosphorylation and also augmented EGF-stimulated Akt phosphorylation. The cooperative effects of thrombin on Akt/p70S6K phosphorylation and [3H]thymidine incorporation were all attenuated by heterologous expression of Gβγ sequestrants. These data suggest that PI3K-dependent T389/T229 phosphorylation is limiting in late-phase p70S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell growth.
Synthesis of MoS/sub 2/ nanostructures from nano-size powder by thermal annealing (2002)

It have been shown that the molybdenite could be the first inorganic fullerene-style molecular shell (MoS/sub 2/)n, of perhaps several materials, based on the transition metal chalcogenides, which could be allowed to create nanocages and nanotubes. We first describe in detail the attempt to produce nanostructures from nano-size MoS/sub 2/ powder by thermal annealing in vacuum conditions. We show the chemical synthesis process of nano-size MoS/sub 2/ powder and the technological regimes of thermal treatment of molybdenite nano-size powder. The TEM images of thermal treated molybdenite powder show the appearance of curvature of reflective planes [002], which could be considered as initial seeds for nanostructures.
A simple analytical model for the energy-efficient activation of access points in dense WLANs (2010)

Energy efficient networks are becoming a hot research topic, and the networking community is increasingly devoting its attention to the identification of approaches to save energy in the networks of today. However, the networks of tomorrow will require built-in energy efficiency capabilities, so that new design techniques based on network models that account for energy efficiency are called for.
Devolatilization and Cracking Characteristics of Australian Lumpy Coals (2007)

An experimental study was conducted to investigate the devolatilization characteristics of five Australian coals in a thermogravimetric analysis (TGA) reactor by varying the coal lump size and the temperature. The swelling ratio was measured after thermal treatment of coal lumps in a horizontal tube furnace at 1273 K while the cracks generated in the lumpy char samples were examined using scanning electron microscopy (SEM). Physical and chemical properties of coal and char samples were measured using CO2 gas adsorption, Hg porosimetry, X-ray fluorescence (XRF) and X-ray diffraction (XRD). Under all the tested conditions, the total volatile yield of lumpy coals was found to be not influenced by either the temperature or particle size and was similar to that indicated in proximate coal analysis. However, as expected, the devolatilization rates were found to increase with increasing temperature as well as the increasing amount of volatiles present in the coal. The study further demonstrated that the effect of coal properties on the devolatilization rates of lumpy coals may not be significant as the rates decrease with increasing lump size, such that coal lumps with sizes more than 10 mm indicated similar orders of reaction rates. The apparent activation energy of coal lumps indicated a linear correlation with the stack height of the carbon crystallite of coals. The study demonstrated that the cracking and swelling behavior of coals was influenced by physical as well as chemical properties, particularly their modification during devolatilization conditions. The study showed that coals with low volatiles indicated high cracking which would increase further with increasing lump size in accordance with the size effect. The cracking tendency of coals appeared to have a reciprocal association with swelling tendency such that less swelling coals are more vulnerable to cracking.
Proactive Management of Systems via Hybrid Analytic Techniques (2015)

In today's scaled out systems, co-scheduling data analytics work with high priority user workloads is common as it utilizes better the vast hardware availability. User workloads are dominated by periodic patterns, with alternating periods of high and low utilization, creating promising conditions to schedule data analytics work during low activity periods. To this end, we show the effectiveness of machine learning models in accurately predicting user workload intensities, essentially by suggesting the most opportune time to co-schedule data analytics work. Yet, machine learning models cannot predict the effects of performance interference when co-scheduling is employed, as this constitutes a "new" observation. Specifically, in tiered storage systems, their hierarchical design makes performance interference even more complex, thus accurate performance prediction is more challenging. Here, we quantify the unknown performance effects of workload co-scheduling by enhancing machine learning models with queuing theory ones to develop a hybrid approach that can accurately predict performance and guide scheduling decisions in a tiered storage system. Using traces from commercial systems we illustrate that queuing theory and machine learning models can be used in synergy to surpass their respective weaknesses and deliver robust co-scheduling solutions that achieve high performance.
A recursive maximum likelihood estimator for the online estimation of electromechanical modes with error bounds (2013)

Summary form only given. Accurate and near real-time estimates of electromechanical modes are of great importance since the modal damping is a key indicator of the stability of the power system. If the estimates of the electromechanical modes are to be useful, knowing the variability in the estimates is critically important. This paper presents a method of directly estimating the variance of each mode estimate in addition to estimating the frequency and damping of each mode in an online setting using a recursive maximum likelihood (RML) estimator. The variance estimates are achieved using two closed-form multidimensional Taylor series approximations, the details of which are fully derived here. The proposed method is validated using a Monte Carlo simulation with a low order model of the Western Electricity Coordinating Council (WECC) power system under both ambient and probing conditions, with multiple modes closely spaced in frequency, and is compared to the regularized robust recursive least squares (R3LS) method. It is also successfully applied to phasor measurement unit (PMU) data collected from the actual WECC system, also under both ambient and probing conditions.
Τεχνικές πολλαπλών κεραιών (MIMO) και συνεργατικής διαφορικότητας σε ασύρματες επικοινωνίες (2009)

Αντικείμενο της παρούσας Διατριβής είναι οι τεχνικές διαφορικότητας στις ασύρματες επικοινωνίες και πιο συγκεκριμένα οι τεχνικές διαφορικής λήψης και εκπομπής, οι τεχνικές πολλαπλών εισόδων πολλαπλών εξόδων (ΜΙΜΟ) και οι τεχνικές συνεργατικής διαφορικότητας. Στην παρούσα Διατριβή καλύπτονται θέματα και τεχνικές που αφορούν την επίδοση των συστημάτων διαφορικότητας στην διάδοση με συσχετισμένα λογαριθμοκανονικά κανάλια καθώς και στην διάδοση ελευθέρου χώρου. Επίσης προτείνονται τεχνικές βελτιστοποίησης της πολυπλοκότητας δεκτών σε τηλεπικοινωνιακά συστήματα πολλαπλών κεραιών. Στο κεφάλαιο 1 της Διατριβής παρουσιάζονται νέες μαθηματικές εκφράσεις σημαντικών παραμέτρων που χαρακτηρίζουν την επίδοση τεχνικών διαφορικής λήψης σε κανάλια με συσχετισμένες λογαριθμοκανονικές διαλείψεις. Πιο συγκεκριμένα, προτείνονται μαθηματικές εκφράσεις της πιθανότητας αποκοπής και της συνάρτησης πυκνότητας πιθανότητας του τελικού σηματοθορυβικού λόγου της διαφορικής λήψης, της ροπογεννήτριας συνάρτησης και της μέσης τιμής του λογαρίθμου του αθροίσματος δύο συσχετισμένων λογαριθμοκανονικών μεταβλητών, και της εργοδικής χωρητικότητας και της μέσης πιθανότητας σφάλματος ψηφίου ενός δέκτη με δύο κλάδους διαφορικότητας με συσχετισμένες λογαριθμοκανονικές διαλείψεις. Τέλος προτείνεται μια ερμηνεία της συσχέτισης ως αύξηση στις λογαριθμοκανονικές μεταβλητότητες ενός ισοδύναμου συστήματος με δύο ασυσχέτιστους κλάδους διαφορικότητας. Στο κεφάλαιο 2 της Διατριβής εξετάζεται η περίπτωση ενός συστήματος συνεργατικής διαφορικότητας με επαναλήπτη. Προτείνονται αναλυτικοί τύποι οι οποίοι περιγράφουν την ολική πιθανότητα αποκοπής ενός συνεργατικού συστήματος σε κανάλια με συσχετισμένες λογαριθμοκανονικές διαλείψεις. Επίσης περιγράφεται αναλυτικά η αποδοτικότητα της συνεργασίας, σε σύγκριση με συστήματα μη συνεργασίας, μέσω της μελέτης της επίπτωσης του τρόπου πολλαπλής πρόσβασης των συνεργαζόμενών κόμβων στο μέσο αλλά και μέσω της μελέτης της συνολικής χρησιμοποιούμενης ενέργειας εκπομπής από το συνεργατικό σύστημα. Στο κεφάλαιο 3 της Διατριβής αναλύεται η επίδοση των τεχνικών πολλαπλών κεραιών σε περιβάλλοντα απόλυτης οπτικής ζεύξης, όπου δεν εμφανίζονται φαινόμενα όπως η πολλαπλή σκέδαση. Η παρεχόμενη ανάλυση αφορά στοιχειοκεραίες με τυχαίο προσανατολισμό και κατευθυντικά στοιχεία. Τέλος διερευνάται η καταλληλότητα των τεχνικών ΜΙΜΟ κατά τη διάδοση στις χιλιοστομετρικές συχνότητες συναρτήσει της απόστασης της ζεύξης καθώς και της απόστασης μεταξύ των στοιχείων κάθε κεραίας. Στο κεφάλαιο 4 της Διατριβής παρουσιάζεται το πρόβλημα του σχεδιασμού της αλυσίδας επεξεργασίας τυπικών δεκτών MIMO-OFDM λαμβάνοντας υπόψη το ρυθμό επεξεργασίας και το ρυθμό της άφιξης των προς-επεξεργασία δεδομένων. Στη συνέχεια, λαμβάνοντας υπόψη τη δομή των πακέτων επικοινωνίας, προτείνονται συγκεκριμένοι αλγόριθμοι προ-επεξεργασίας ΜΙΜΟ οι οποίοι παρέχουν βελτιστοποιήσεις στη συνολική πολυπλοκότητα του δέκτη.