gebhart/patrepeval huggingface dataset:
Memory-Based Data-Driven MRAC Architecture Ensuring Parameter Convergence (2016)

Convergence of controller parameters in standard model reference adaptive control (MRAC) requires the system states to be persistently exciting (PE), a restrictive condition to be verified online. A recent data-driven approach, concurrent learning, uses information-rich past data concurrently with the standard parameter update laws to guarantee parameter convergence without the need of the PE condition. This method guarantees exponential convergence of both the tracking and the controller parameter estimation errors to zero, whereas, the classical MRAC merely ensures asymptotic convergence of tracking error to zero. However, the method requires knowledge of the state derivative, at least at the time instances when the state values are stored in memory. The method further assumes knowledge of the control allocation matrix. This paper addresses these limitations by using a memory-based finite-time system identifier in conjunction with a data-driven approach, leading to convergence of both the tracking and the controller parameter estimation errors without the PE condition and knowledge of the system matrices and the state derivative. A Lyapunov based stability proof is included to justify the validity of the proposed data-driven approach. Simulation results demonstrate the efficacy of the suggested method.
Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines Facet Joint Interventions 2020 Guidelines. (2020)

Chronic spinal pain, interventional techniques, diagnostic blocks, therapeutic interventions, facet joint nerve blocks, intraarticular injections, radiofrequency neurolysis.
Preventing recurrence of diffuse malignant peritoneal mesothelioma (2016)

This review describes patient selection and operative goals with CRS and IPC, the reported outcomes with this approach, and the data supporting platinum-based IPC. We assess the pharmacokinetics supporting the use of dwell IPC. We outline clinical, imaging and laboratory surveillance for recurrence. In addition, we highlight the role of re-operation, both as a planned second procedure and in the context of disease recurrence. Literature review was performed via Medline search. Expert commentary: CRS/IPC offers survival benefit in selected patients with DMPM, but given the high rate of recurrence, close surveillance is needed post-operatively. Strategies to prevent and treat recurrent disease include dwell IPC and second CRS/IPC.
Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy (2013)

In subjects with TBII above the mean +1 SD, we observed an increase of IGF-IR stimulating activity with age. In a subgroup of these patients, depletion of IgGs significantly decreased IGF-IR stimulating activity, suggesting that, in a subset of patients with GO, IgGs may have IGF-IR stimulating activities.
A Pathway for Photosynthetic Carbon Flow to Mannitol in Celery Leaves (1983)

In the polyol producing plant, celery (Apium graveolens L.), mannitol is a major photosynthetic product and a form in which carbohydrate is translocated. Measurements of whole leaf extracts of celery indicated substantial activity of the following enzymes: mannose-6-P reductase, mannose-6-P isomerase, mannitol-1-P phosphatase, and nonreversible glyceraldehyde-3-P dehydrogenase. The activities of these enzymes were either undetectable or very low in the nonpolyol producing plants, Secale cereale L. (rye) and Vigna mungo (L.) Hepper (black gram).Mesophyll protoplasts were enzymically isolated from celery leaves, broken with a Yeda press and the intracellular localization of the above enzymes for mannitol synthesis studied following differential and/or sucrose density gradient centrifugation of the protoplast extract. These data suggested the enzymes involved in mannitol synthesis are exclusively localized in the cytoplasm. Ninety-five to 100% of the activity of these enzymes, along with the cytoplasmic marker enzyme phosphoenolpyruvate carboxylase, was found in the cytosolic fraction.We propose the pathway of photosynthetic carbon flow from triose-P to mannitol in celery occurs via fructose-6-P, mannose-6-P, and mannitol-1-P; these final reactions being catalyzed by the cytoplasmic enzymes, mannose-6-P isomerase, NADPH-dependent mannose-6-P reductase, and mannitol-1-P phosphatase, respectively. The requirement for NADPH may be met via the cytoplasmically located NADP-linked nonreversible glyceraldehyde-3-P dehydrogenase.
The aqueous supramolecular chemistry of cucurbit[n]urils, pillar[n]arenes and deep-cavity cavitands (2017)

This tutorial review summarizes the continuing exploration of three prominent water-soluble hosts: cucurbiturils, pillar[<italic>n</italic>]arenes and deep-cavity cavitands.
Subplate Neurons and the Patterning of Thalamocortial Connections (2007)

The patterning of the cerebral cortex into functionally distinct domains relies on the formation of appropriate connections between the thalamus and the cortex during development. To identify the mechanisms that underlie cortical target selection by thalamic axons, we have examined the role of cellular interactions in the formation of connections between the lateral geniculate nucleus (LGN) and the visual cortex during development of the cat visual system. The morphology of LGN axons as they grow towards the visual cortex suggests that interactions within the subplate zone may be important in the development of geniculocortical connections. The requirement for subplate neurons in this process was examined by ablating subplate neurons underlying the visual cortex at various developmental stages. When subplate cells are deleted between E38 and E42, prior to target innervation by LGN axons, these axons fail to select the visual cortex as their correct target and instead grow past it, staying restricted to the white matter. Deletion of subplate cells at later stages, between P2 and P7, does not affect target selection, but instead it prevents the segregation of LGN axons into ocular dominance columns within layer IV of the cortex. The effects of subplate neuron ablation suggest that interactions between thalamic axons and subplate cells are of critical importance in the specification of thalamocortical connections during development.
Hersenbeschadiging na perinatale asfysie (1997)

Vooral de eerste uren na de geboorte zijn cruciaal voor het optreden van hersenschade door perinatale asfyxie. Het blijkt namelijk dat de beschadiging van de hersenen niet stopt op het moment dat er weer voldoende zuurstof aanwezig is. Juist gedurende de herstelfase, dus nadat het zuurstoftekort is opgeheven, treedt er een tweede periode van hersenbeschadig ing op. Deze speelt met name in de latere mentale en psychomotorische ontwikkeling een belangrijke rol.
Proposed Method to Predict Core Inventory history and Operator Time Margin during Small Break Accident (1983)

The blowdown history of the TMI-2 accident up to the isolation of the relief valve associated with a small break LOCA is reviewed briefly. An analysis is made to determine what instruments should be added in the core in order to prevent core damage in the case of the TMI-2 accident. With the added instruments a procedure is presented on how to predict the uncovered level of the core and how to calculate operator time margin. Sample calculations are done for the TMI-2 accident to determine the uncovered level and operator time margin. Finally, the map to show the uncovered level of the core and operator time margin is drawn with measurable parameters by the above methods.
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis (2019)

This Article contains an error in the last sentence of the 'Variant analysis suggests they are pathogenic' section of the Results, which incorrectly reads 'No truncated PIEZO1 protein products were identified in western blot analysis in GLD1:II.3 and GLD2:II.2 (Fig. 2, Supplementary Fig. 6), suggesting that the truncated protein is not stable and therefore degraded.' This should read 'No full-size PIEZO1 protein products were identified in western blot analysis in GLD1:II.3 and GLD2:II.2 (Fig. 2, Supplementary Fig. 6); the three nonsense mutations are predicted to lead to premature termination of the protein, hence it is possible that those truncated proteins will be non-functional or even unstable and degraded.' The error has not been fixed in the PDF or HTML versions of the Article.
Implementable Ethics for Autonomous Vehicles (2015)

As agents moving through an environment that includes a range of other road users – from pedestrians and cyclists to other human or automated drivers – automated vehicles continuously interact with the humans around them. The nature of these interactions is a result of the programming in the vehicle and the priorities placed there by the programmers. Just as human drivers display a range of driving styles and preferences, automated vehicles represent a broad canvas on which the designers can craft the response to different driving scenarios.
Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. (2004)

One of the most promising strategies for cancer prevention today is chemoprevention using readily available natural substances from vegetables, fruits, herbs and spices. Among the spices, saffron (Crocus sativus, L) a member of the large family Iridaceae, has drawn attention because apart from its use as a flavouring agent, pharmacological studies have demonstrated many health promoting properties including radical scavenging, anti- mutagenic and immuno-modulating effects. In the present study the effects of an aqueous infusion of saffron on two stage skin papillogenesis / carcinogenesis in mice initiated by 7-12 dimethyl benz[a] anthracin (DMBA) and promoted with croton oil were investigated. Significant reduction in papilloma formation was found with saffron application in the pre-initiation and post-initiation periods, and particular when the agent was given both pre- and post-initiation. The inhibition appeared to be at least partly due on modulatory effects of saffron on some phase II detoxifying enzymes like glutathione-S-transferase (GST) and glutahinoe peroxidase (GPx), as well as catalase (CAT) and superoxide dismutase (SOD).
Microwave Radiation Effect on Ultra Film Formation of Polyisoprene Inside Admicelle Adsorbed on Silica Surface (2009)

Microwave radiation was induced to polymerize polyisoprene film inside the adsorbed surfactant on the silica surface, so called admicellar polymerization technique. The effect of microwave power on film formation was studied. The reaction time was also varied depending on the use of microwave power. The results showed the comparison of the polymer film formation prepared by microwave and conventional (thermal) system. The formed film was identified by several techniques consisting of FT-IR, UV-Visible spectrophotometer, SEM and TEM. The quantitative analysis of film formation was also determined by gravimetric analysis (burning) in term of % weight loss.
The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision (2021)

Protein-coding and non-coding genes like miRNAs tightly control hematopoietic differentiation programs. Although miRNAs are frequently located within introns of protein-coding genes, the molecular interplay between intronic miRNAs and their host genes is unclear. By genomic integration site mapping of gamma-retroviral vectors in genetically corrected peripheral blood from gene therapy patients, we identified the EVL/MIR342 gene locus as a hotspot for therapeutic vector insertions indicating its accessibility and expression in human hematopoietic stem and progenitor cells. We therefore asked if and how EVL and its intronic miRNA-342 regulate hematopoiesis. Here we demonstrate that overexpression (OE) of Evl in murine primary Lin<sup>-</sup> Sca1<sup>+</sup> cKit<sup>+</sup> cells drives lymphopoiesis whereas miR-342 OE increases myeloid colony formation in vitro and in vivo, going along with a profound upregulation of canonical pathways essential for B-cell development or myelopoietic functions upon Evl or miR-342 OE, respectively. Strikingly, miR-342 counteracts its host gene by targeting lymphoid signaling pathways, resulting in reduced pre-B-cell output. Moreover, EVL overexpression is associated with lymphoid leukemia in patients. In summary, our data show that one common gene locus regulates distinct hematopoietic differentiation programs depending on the gene product expressed, and that the balance between both may determine hematopoietic cell fate decision.
Supplementary Figure S3 from Lack of p53 Ser389 Phosphorylation Predisposes Mice to Develop 2-Acetylaminofluorene–Induced Bladder Tumors but not Ionizing Radiation–Induced Lymphomas (2023)

Supplementary Figure S3 from Lack of p53 Ser389 Phosphorylation Predisposes Mice to Develop 2-Acetylaminofluorene–Induced Bladder Tumors but not Ionizing Radiation–Induced Lymphomas
34.2 A 28-nm Bulk-CMOS IC for Full Control of a Superconducting Quantum Processor Unit-Cell (2023)

While large-scale fault-tolerant quantum computers promise to enable the solution to certain classes of problems for which no other efficient approach is known, such a machine is believed to require over a million performant qubits. Scaling today's 0(100) qubit superconducting (SC) quantum computers to this extent while also improving performance carries many daunting challenges, including control of such a large quantum processor (QP). Integrating the control electronics at an intermediate temperature stage within the cryostat is an attractive option, e.g., due to the inherent thermal stability of the cryogenic environment and the feasibility of connecting to the QP via dense low-loss/high-thermal-isolation SC lines [1], [2]. Several cryo-CMOS quantum controllers have been reported, with examples used to control spin [3] and transmon [1], [2] qubits. To date, IC-based quantum control experiments have focused on resonant RF control, but baseband signals are often central to the execution of gates. Here, we report the design and system characterization of a cryo-CMOS IC for generating both the RF and baseband signals required for full control of a SC QP unit-cell, and show its ability to implement the components of a high-fidelity gate set that is universal for quantum computing.
Profile Modification and Water Control With Silica Gel-Based Systems (1985)

ABSTRACT A major problem in maximizing oil production potential is the maintenance of adequate mobility control and favorable permeability profiles within the reservoir. Currently, polymer systems are receiving a great deal of attention in this application, not only as viscosifying agents, but also as cross-linked/gelled water blocking agents. Traditionally, silica gel systems had been used for such purposes. They still offer advantages in situations where polymer systems are limited by degradation and syneresis or are inadequate to shut off major thief zones. This paper presents the chemistry of silica polymer gel systems, and reviews their properties, benefits, limitations, and methods of application. The properties such as gel time, strength, and shrinkage vary considerably versus the concentrations of reactants, the type of acidifying/gelling agent used, or the particular reservoir environmental conditions such as temperature, salinity, hardness, and hydrocarbon saturation. Gels ranging from elastic to rigid can be made with set times varying from a few seconds to several hours. Inorganic acids and reactants such as CaCl2 or NaAlO2 tend to react quite rapidly. Organic reactants that slowly hydrolyze or oxidize give more gradual formation of gels. Most reservoirs that contain high salinity, hardness, or temperature environments tend to accelerate the gel formation. Examples of these effects are presented for several silicate based systems. Also the gelation of silicate in the presence of organic chemicals is discussed. Information from the grouting literature is reviewed so that a complete picture can be presented on the use and application of silicate based water control and production methods.
3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone:  Potent Inhibitors of Lipid Peroxidation and Cell Toxicity (2000)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell ToxicityDavid Bebbington, Nathaniel J. T. Monck, Suneel Gaur, Alan M. Palmer, Karen Benwell, Victoria Harvey, Craig S. Malcolm, and Richard H. P. PorterView Author Information Departments of Chemistry and Molecular Pharmacology, Cerebrus, Oakdene Court, 613 Reading Road, Winnersh, Wokingham RG41 5UA, U.K. Cite this: J. Med. Chem. 2000, 43, 15, 2779–2782Publication Date (Web):July 8, 2000Publication History Received3 November 1999Published online8 July 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/jm990945vhttps://doi.org/10.1021/jm990945vrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1060Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Mechanisms of action,Molecules,Oxidative stress,Peroxidation,Toxicity Get e-Alerts
Tetraazacyclophanes by Palladium-Catalyzed Aromatic Amination. Geometrically Defined, Stable, High-Spin Diradicals (1999)

Neutral tetraazacyclophanes were prepared in a one-step palladium-catalyzed amination reaction. Simple oxidation of these materials creates dication diradicals that are stable at room temperature and that are geometrically well defined. The electronic and magnetic properties of the dications were investigated by CV, UV−vis, and EPR spectroscopy. These spectral data and solution phase magnetic susceptibility measurements indicate high spin ground states in certain media. EPR zero field splitting parameters for the diradical suggest that the distance between the two radical sites can be approximated simply by the distance between alternating nitrogens in the macrocycle.
On the possible impact of PWM drives on insulating materials: a laboratory study (1999)

The interaction of stresses resulting from adjustable speed drives (ASD) on dielectric materials used in stator winding insulation of rotating machines is presented. The main results are presented and discussed for induction motor ASD.
Fire Properties of Polystyrene−Clay Nanocomposites (2001)

Polystyrene−clay nanocomposites have been prepared using a bulk polymerization technique. Three new “onium” salts have been used to prepare the nanocomposites, two are functionalized ammonium salts while the third is a phosphonium salt. By TGA/FTIR, both ammonium and phosphonium treatments have been shown to degrade by a Hofmann elimination mechanism at elevated temperatures. TGA/FTIR showed that the phosphonium treatment is the most thermally stable treatment when compared to the two ammonium salts. The nanocomposites were characterized by X-ray diffraction, transmission electron microscopy, strength and elongation at break, as a measure of the mechanical properties, thermogravimetric analysis, and cone calorimetry. The onset temperature of the degradation is increased by about 50 °C and the peak heat release rate is reduced by 27−58%, depending upon the amount of clay that is present. The mass loss rates are also significantly reduced in the presence of the clay.
An Organic Thin‐Film Transistor with a Photoinitiator‐Free Photosensitive Polyimide as Gate Insulator (2005)

Abstract This investigation deals with the synthesis and detailed study of a photoinitiator‐free photosensitive polyimide gate insulator for organic thin‐film transistors (OTFTs), one of the most important components of active‐matrix displays on plastic substrates. The photosensitive polyimide precursor poly(amic acid) is prepared from the aromatic dianhydride 3,3′,4,4′‐benzophenone tetracarboxylic dianhydride (BTDA) and the novel aromatic diamine 7‐(3,5‐diaminobenzoyloxy)coumarine (DACM). The photosensitivity of the poly(amic acid) film is investigated using a high‐pressure mercury lamp at 280–310 nm. The pattern resolution of the photocured film was about 50 μm. The surface morphology of the films before and after the photopatterning process is also investigated. In addition, we have fabricated pentacene OTFTs with the photoinitiator‐free photosensitive polyimide as gate insulator. The OTFT characteristics are discussed in more detail with respect to the electrical properties of the photosensitive polyimide thin film.
The Transmittance, Transmittance Wavefront, and Laser Induced Damage Properties of Thin Fluoride Polymer Films May Be Used as Short Pulse Laser Debris Shields (2016)

Debris mitigation which pollutes and even damages the optical elements is a major challenge for all high-peak-power lasers system. In order to solve the problem, we employed some preliminary research. In this work, first, the film optical properties of fluorinated ethylene propylene (FEP), perfluoroalkoxy copolymer (PFA), and ethane-tetrafluoroethylene copolymer (ETFE) were investigated with respect to their possible application as laser debris shields. The results indicate that three of the polymer films have high transmittance at 355 nm, especially in FEP film, the transmittance of which at 355 nm is near to 94%. The transmittance wavefront and the laser that induce damage of FEP film were investigated further. The result indicates that the wavefront error of FEP film (with a diameter of 90 mm) is about 0.33 λ . The damage test was performed by a 355 nm neodymium:yttrium aluminum garnet (Nd:YAG) laser with a 9.3 ns pulse duration, and it was found that the highest nondamage fluence for FEP film is 10.35 J/cm 2 . Through a demonstration experiment, it was testified that the FEP film can prevent large amount of metal fractions and the FEP film can be used as the debris shields indeed.
Treating Arthritis and Cartilage Injuries (2010)

Includes descriptive metadata provided by producer in MP3 file: Sports Medicine - Vanderbilt Health Radio Interviews - Treating Arthritis and Cartilage Injuries. By Debbie Alan and James Carey, MD, MPH.