gebhart/patrepeval huggingface dataset:
Physico-mechanical Properties of Paper Sludge-Thermoplastic Polymer Composites (2004)

This study investigates the effect of paper sludge’s mixing ratio and the types and concentrations of coupling agents on the physical and mechanical properties of paper sludge-thermoplastic polymer composites. In the experiment, four levels of mixing ratios of paper sludge to thermoplastic polymer (10: 90, 20: 80, 30: 70 and 40: 60) and three levels of coupling agent (Epolene G-3003 TM ) content (1, 3, and 5 wt.%) were designed to discuss the physical and mechanical properties of composite. Composite density, as expected, increased but melt flow index decreased when the paper sludge content increased. Thickness swelling and water absorption of composites was slightly improved by the addition of paper sludge compared with control specimens. Tensile properties of composites significantly increased as the mixing ratio of paper sludge increased. Especially, tensile modulus improved with the increase of paper sludge content. Flexural strength and modulus showed similar trends to that of the tensile properties. Notched and unnotched Izod impact strengths lowered by the addition of paper sludge. With the addition of coupling agent, G-3003 TM , tensile and flexural properties improved considerably compared with control specimens (without any coupling agent). Epolene G-3003 TM , with high molecular weight, was effective in the improvement of the composites’ tensile and flexural properties.
Differences in 11C-PIB-PET Imaging Patterns In Patients With Alzheimer’s Disease Without Microbleeds And Those With Cerebral Amyloid Angiopathy (P6.320) (2014)

OBJECTIVE: To clarify differences in 11 C-Pittsburgh compound B (PIB)-positron emission tomography (PET; 11 C-PIB-PET) imaging patterns in patients with Alzheimer’s disease (AD) without cortical/subcortical microbleeds (CMBs), and in those with cerebral amyloid angiopathy (CAA).
 BACKGROUND: PIB is a PET ligand that binds to β-amyloid in vivo. The 11 C-PIB-PET will become useful diagnostic imaging tool for both CAA and AD. However, AD is frequently accompanied with CAA. It is important to distinction of CAA and AD without CAA that we clarify differences in 11 C-PIB-PET imaging patterns in patients with AD without CMBs, and in those with CAA.
 DESIGN/METHODS: We examined 13 patients diagnosed with AD without CMBs based on clinical criteria (mean ± SD age, 70.8 ± 8.4 years; females, 11; males, 2; mean ± SD Mini-Mental Status Examination [MMSE], 17.4 ± 6.5), and 10 age-matched patients with clinically probable CAA (age, 68.9 ± 9.0 years; females, 6; males, 4; MMSE, 17.4 ± 7.8). We analyzed the standard uptake value ratio (SUV-R) of 50- to 70-min images of scans, divided the imaging data into 24 brain sections by using a 3D stereotaxic ROI template, and compared each image’s average of SUV-R between the patients with CAA and AD patients. The data were assessed by Mann-Whitney U-test, with statistical significance set at P < 0.05.
 RESULTS: Compared to patients with CAA, patients with AD without CMBs had significant higher average SUV-R in the frontal, parietal, and temporal lobes, and not lower in occipital lobes. The anterior/occipital ratio was not significant higher in patients with AD than in patients with CAA. This difference may be reflected by the pathological difference between AD and CAA.
 CONCLUSIONS : 11 C-PIB-PET imaging patterns were different between AD and CAA. Disclosure: Dr. Hayashi has nothing to disclose. Dr. Shinoda has nothing to disclose. Dr. Yoshikura has nothing to disclose. Dr. Waza has nothing to disclose. Dr. Asano has nothing to disclose. Dr. Kimura has nothing to disclose. Dr. Inuzuka has nothing to disclose.
Proteomic Analysis of Mice Hippocampus in Simulated Microgravity Environment (2006)

Space travel induces many deleterious effects on the flight crew due to the '0' g environment. The brain experiences a tremendous fluid shift, which is responsible for many of the detrimental changes in physical behavior seen in astronauts. It therefore indicates that the brain may undergo major changes in its protein levels in a '0' g environment to counteract the stress. Analysis of these global changes in proteins may explain to better understand the functioning of brain in a '0' g condition. Toward such an effort, we have screened proteins in the hippocampus of mice kept in simulated microgravity environment for 7 days and have observed a few changes in major proteins as compared to control mice. Essentially, the results show a major loss of proteins in the hippocampus of mice subjected to simulated microgravity. These changes occur in structural proteins such as tubulin, coupled with the loss of proteins involved in metabolism. This preliminary investigation leads to an understanding of the alteration of proteins in the hippocampus in response to the microgravity environment.
Iron deficiency anemia with menorrhagia: Ferric carboxymaltose a safer alternative to blood transfusion (2018)

Intravenous FCM is an effective and a safe treatment option for IDA with a single administration of high dose without serious adverse effects obviating the need for blood transfusion before surgery.
Evaluation of collagen-elastin hybrid tissue engineered vascular constructs (2003)

Collagen-based tissue engineered replacements for small diameter blood vessels have been investigated for many years but typically lack the elasticity and tensile strength necessary for implantation. In this study, we have incorporated elastin with an organized structural architecture into tubular cell-seeded collagen constructs using two different reconstituted collagen sources. We evaluated the mechanical, chemical, and biological properties of these collagen-only and collagen-elastin hybrid grafts. Gel compaction quantification and live/dead staining revealed that cells in all matrix combinations were viable and able to rapidly compact their surrounding matrix. Compared to controls, uniaxial tensile testing revealed an increase in ultimate tensile strength and linear modulus for elastin hybrid constructs and for constructs formed with bovine dermal type I collagen. Histological assessment showed the unique composite structure of the elastin hybrid construct as well as the cell and extracellular matrix organization in all constructs studied. A discussion of these findings and their importance to vascular tissue engineering is discussed.
An operator's perspective on propagation (2014)

In satellite communications, Quality of Service is a key parameter closely related to propagation characteristics of a communications link at a given frequency and for a geographical location. Over the years, a lot of effort has been spent into collecting data and into modeling propagation at various frequency bands of interest, i.e. C-band, Ku-band and Ka-band. In particular, efforts in propagation modeling have been directed towards the requirements of professional communications, giving parameters like link availability over a year or the worst month. With the advent of consumer applications in particular through High Throughput Satellite (HTS) systems, the distribution of statistics becomes an important element. In general, as frequencies increase, the amount of propagation data available is less abundant and consequently less accurate predictions can be expected. As we move up in frequency, Fade Mitigation Techniques (FMT) are of great importance. In particular, if we assume that feeder links of next generation HTS will work in Q/V bands or even beyond, where propagation effects are more severe, we have to think about innovative approaches to site diversity. In these systems, M links are available when N links are required, where M>N. The problem shifts from classical site diversity to system dimensioning where we can see an interesting cross-roads between propagation and networks. Space-time channel characterization and modeling of the propagation channel will certainly help in the prediction and optimization of Quality of Service associated to earth-space communications links.
Current generation by running holographic gratings and photo-induced self-organization in the suspension of microorganisms (2002)

Summary form only given.We have observed nonlinear optical and photoelectric responses in suspensions of microorganisms (different species of algae). Also we have seen a self-organization of the laser scattering in the circular rings for different tested wavelengths (633, 474, and 515 nm with power /spl sim/0.05-0.1 mW). A light beam from a He-Ne laser at 633 nm was used to look at special structures generated by a suspension of Chlamydomonas renhardtii. The incident power, 6 mW of unexpanded beam with a diameter of 2 mm, resulted in algae moving along helical trajectories away from the light spot. First, the algae began to move clockwise and then, after 1-2 min they moved counterclockwise. If a small spot was brought on the cuvette, the algae manifested negative phototaxis such that all the algae concentrated in the upper and bottom parts of the cuvette after moving away from the illuminated area. The transmission increased to about 1.3 times for the beam at wavelength 633 nm. No positive phototaxis was detected at any laser wavelength. A current of about 100-120 nA was detected under light illumination of 10 mW/cm/sup 2/ and without running fringes. After the grating began to move, there was a distinct change of electric current up to 900-1000 nA. The change of direction of running fringes resulted in the current changing its sign. The value of the current does not depend on the speed on the running fringes, which was varied from 0 to 10/sup 3/ /spl mu/m/sec. Further, there was a drop of of current with time. After 2-3 h of illumination of the cuvette with running fringes, there was a degradation of the current down to 100 nA corresponding to illumination without running fringes.
[Beta-thalassemia major complicated with Vibrio vulnificus septicemia: report of one case]. (1994)

Vibrio vulnificus is a halophilic Vibrio that has been isolated repeatedly from sea-water and shellfish during the warm months of the year. It's a virulent pathogen for men and is frequently associated with overwhelming infections including sepsis, gangrene of extremities and high mortality rate. We encountered a 13-year-old boy who had a history of beta-thalassemia major with secondary hemochromatosis, suffering from vomiting, diarrhea, fever and hypotension. Physical examination revealed that ecchymosis, bullae and ulceration were noted over the left leg. Vibrio vulnificus was isolated from the blood. Initially, the patient did not respond to the appropriate antibiotics treatment, subsequently surgical debridement was performed. After that, the patient recovered gradually, and discharged home after 17 days of admission. In conclusion, when patients present with sepsis and/or characteristic skin lesion-hemorrhagic bullae, particularly those with thalassemia major, hemochromatosis or underlying liver disease and a history of marine exposure, clinicians should be alerted to this potentially fatal infection and should commence appropriate assessment and treatment immediately.
Molecular profiles of thyroid cancer subtypes: Classification based on features of tissue revealed by mass spectrometry imaging (2016)

Determination of the specific type of thyroid cancer is crucial for the prognosis and selection of treatment of this malignancy. However, in some cases appropriate classification is not possible based on histopathological features only, and it might be supported by molecular biomarkers. Here we aimed to characterize molecular profiles of different thyroid malignancies using mass spectrometry imaging (MSI) which enables the direct annotation of molecular features with morphological pictures of an analyzed tissue. Fifteen formalin-fixed paraffin-embedded tissue specimens corresponding to five major types of thyroid cancer were analyzed by MALDI-MSI after in-situ trypsin digestion, and the possibility of classification based on the results of unsupervised segmentation of MALDI images was tested. Novel method of semi-supervised detection of the cancer region of interest (ROI) was implemented. We found strong separation of medullary cancer from malignancies derived from thyroid epithelium, and separation of anaplastic cancer from differentiated cancers. Reliable classification of medullary and anaplastic cancers using an approach based on automated detection of cancer ROI was validated with independent samples. Moreover, extraction of spectra from tumor areas allowed the detection of molecular components that differentiated follicular cancer and two variants of papillary cancer (classical and follicular). We concluded that MALDI-MSI approach is a promising strategy in the search for biomarkers supporting classification of thyroid malignant tumors. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.
Very high aspect ratio hot-wire based MEMS thermal sensor for near wall turbulent flow measurement with high sensitivity and low power consumption (2016)

We present an effcient and high-sensitive micro-electro-mechanical system (MEMS) thermal hot-wire based flow sensor for near wall flow measurement. By combining substreate-free wire structure and mechanical support by silicon oxide micro-bridges, the sensor wires achieve a very high aspect ratio, superior to 300, with 1 mm long for only 3 µm wide. The sensor is designed for compromising conventional hot-film and hot-wire sensors and to achieve high sensitivity to the near wall flow velocity, fast response time and flow direction detection. The sensor can be mounted flush to the wall for technical application, sush as flow control and separation detection, or for understanding near wall shear flows. We present here the design and micro-fabrication, then electrical and thermal characterizations and finally the first experiments in a turbulent boundary layer wind tunnel.
Higher Screening Aldosterone to Renin Ratio in Primary Aldosteronism Patients with Diabetes Mellitus (2018)

Accumulated evidence has shown that low renin hypertension is common in patients with diabetic nephropathy. However, the performance of aldosterone to renin ratio (ARR) in primary aldosteronism (PA) patients with diabetes has not been well validated. Here, we report the performance of screening ARR in PA patients with diabetes. The study enrolled consecutive patients and they underwent ARR testing at screening. Then the diagnosis of PA was confirmed from the Taiwan Primary Aldosteronism Investigation registration dataset. Generalized additive model smoothing plot was used to validate the performance of screening ARR in PA patients with or without diabetes. During this study period, 844 PA patients were confirmed and 136 (16.0%) among them had diabetes. Other 816 patients were diagnosed with essential hypertension and used as the control group and 89 (10.9%) among them had diabetes. PA patients with diabetes were older and had a longer duration of hypertensive latency, higher systolic blood pressure and lower glomerular filtration rate than those PA patients without diabetes. The cut-off value of ARR in the generalized additive model predicting PA was 65 ng/dL per ng/mL/h in diabetic patients, while 45 ng/dL per ng/mL/h in non-diabetic patients. There was a considerable prevalence of diabetes among PA patients, which might be capable of interfering with the conventional screening test. The best cut-off value of ARR, more than 65 ng/dL per ng/mL/h in PA patients with diabetes, was higher than those without diabetes.
Towards novel wood-based materials: Chemical bonds between lignin-like model molecules and poly(furfuryl alcohol) studied by NMR (2008)

Abstract Wood modification with furfuryl alcohol is a non-toxic alternative to conventional preservation treatments. A process in which furfuryl alcohol polymerises in situ was previously proposed for chemical modification of wood. In the present work, liquid model systems were investigated using compounds that resemble repeating units of lignin to verify whether chemical bonds form between the furfuryl alcohol polymer and wood. Using different NMR spectroscopic techniques we confirmed that these model compounds do form covalent bonds with the polymerising polymer. The results indicate that the furan polymer grafts to lignin, supporting observations in similar studies performed with genuine wood materials.
Across the tree of life, radiation resistance is governed by antioxidant Mn 2+ , gauged by paramagnetic resonance (2017)

Significance Decades of functional genomic efforts have failed to predict the ability of cells to survive ionizing radiation (IR). Evidence is mounting that small high-symmetry antioxidant complexes of manganous ions with metabolites (H-Mn 2+ ) are responsible for cellular IR resistance, and that H-Mn 2+ protects the proteome, not the genome, from IR-induced reactive oxygen species. We show that the amount of H-Mn 2+ in nonirradiated living cells is readily gauged by electron paramagnetic resonance (EPR) spectroscopy and highly diagnostic of their DNA repair efficiency and survival after gamma-radiation exposure. This spectroscopic measure of cellular H-Mn 2+ content is the strongest known biological indicator of cellular IR resistance between and within organisms across the three domains of the tree of life, with potential applications including optimization of radiotherapy.
Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells (2019)

Hypoxia-inducible factor 1 (HIF-1) plays important roles in cancer cell biology. HIF-1α is reportedly activated by several factors, including protein kinase C (PKC), in addition to hypoxia. We investigated the role of PKC isoforms and the effects of vitamin K2 (VK2) in the activation process of HIF-1α. Human hepatocellular carcinoma (HCC)-derived Huh7 cells were cultured under normoxic and hypoxic (1% O₂) conditions with or without the PKC stimulator TPA. The expression, transcriptional activity and nuclear translocation of HIF-1α were examined under treatment with PKC inhibitors, siRNAs against each PKC isoform and VK2. Hypoxia increased the expression and activity of HIF-1α. TPA increased the HIF-1α activity several times under both normoxic and hypoxic conditions. PKC-δ siRNA-mediated knockdown, PKC-δ inhibitor (rottlerin) and pan-PKC inhibitor (Ro-31-8425) suppressed the expression and transcriptional activity of HIF-1α. VK2 significantly inhibited the TPA-induced HIF-1α transcriptional activity and suppressed the expression and nuclear translocation of HIF-1α induced by TPA without altering the HIF-1α mRNA levels. These data indicate that PKC-δ enhances the HIF-1α transcriptional activity by increasing the nuclear translocation, and that VK2 might suppress the HIF-1α activation through the inhibition of PKC in HCC cells.
ChemInform Abstract: Improved Synthesis of 3,5‐Diamino‐2,4,6‐trinitrotoluene. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simultaneous analysis of defense‐related phytohormones in Arabidopsis thaliana responding to fungal infection (2016)

Quantitative changes indicate increased production of defense phytohormones from the various classes. The analytical method was useful and suitable to distinguish distinctive variations in the phytohormonal profiles and balance in A. thaliana leaves resulting from pathogen attack.
Characterization of Human Placental Cytosolic Adenosine 3′,5′-Monophosphate Phosphodiest erase by Inhibitors and Insulin Treatment* (1990)

To gain insight into the regulation of low Km cAMP phosphodiesterases (PDE) by insulin in human tissues, PDEs in human placenta were studied. Human placenta contained cAMP PDEs in particulate and cytosolic fractions. More than 99% of the total activity was localized in the cytosolic fraction. The cytosolic fraction exhibited at least four cyclic nucleotide PDEs when fractionated by DEAE-cellulose chromatography. The first form was a calmodulin-activated PDE which hydrolyzed both cGMP and cAMP. The second form was a high affinity cAMP PDE with a nonlinear kinetic characteristic, but was not inhibited by either cGMP or cilostamide (either compound is known to specifically inhibit rat insulin-sensitive cAMP PDE). The third form was a low Km cAMP PDE, but was only modestly sensitive to inhibition by cGMP or cilostamide. The fourth form was a cAMP PDE which showed high sensitivity to inhibition by cGMP or cilostamide. The IC50 values of the fourth form were comparable to those of rat adipose insulin-sensitive PDE. However, its Km for cAMP was 2 microM, which is about 10 times higher than that of the rat enzyme. Insulin treatment on placenta tissues stimulated at least two PDEs, the third and fourth forms. To our knowledge, this is the first report to describe insulin-sensitive cAMP PDEs in the cytosolic fraction of human placenta.
Graph Based Classication Methods Using Inaccurate External Classier Information (2012)

In this paper we consider the problem of collectively classifying entities where relational information is available across the entities. In practice inaccurate class distribution for each entity is often available from another (external) classier. For example this distribution could come from a classier built using content features or a simple dictionary. Given the relational and inaccurate external classier information, we consider two graph based settings in which the problem of collective classication can be solved. In the rst setting the class distribution is used to x labels to a subset of nodes and the labels for the remaining nodes are obtained like in a transductive setting. In the other setting the class distributions of all nodes are used to dene the tting function part of a graph regularized objective function. We dene
Biological resolution of racemic 2-oxazolidinones. Part III. Synthesis of (S)-.BETA.-blockers from (S)-5-hydroxymethyl-3-tert butyl-2-oxazolidinone or (S)-5-hydroxymethyl-3-isopropyl-2-oxazolidinone. (1985)

In previous papers,1'2) the authors reported a newroute to produce (S)-5-hydroxymethyl-3-alkyl-2-oxazolidinones 1 (alkyl= tert-buty\ or isopropyl) by the asymmetric hydrolysis of (i?,S)-5-acyloxymethyl-3-alkyl-2-oxazolidinones with Upases or microorganisms as illustrated in Scheme 1. Furthermore, the asymmetric hydrolysis of (i?,S)-5-hexanoyloxymethyl-3-ter/-butyl-2-oxazolidinone or (7?,S)-5-octanoyloxymethyl-3-isopropyl-2oxazolidinone with lipoprotein lipase Amano 3 (L. P. L. Amano3, origin; Pseudomonas aeruginosa)3) efficiently afforded (S)-5-hydroxymethyl-3-te^butyl-2-oxazolidinone la or (S)-5-hydroxymethyl-3-isopropyl-2-oxazOlidinone lb in high enantiomeric excess (99% e.e. each).2) These compounds-are available intermediates for (S)-fiblockers.
Low Stress Die Attach by Low Temperature Transient Liquid Phase Bonding (1992)

A process called Low Temperature Transient Liquid Phase (LTTLP) bonding can allow components to be solder attached in the 60-1WC (140-320T) temperature range but not remelt until a much higher temperature. Stress is minimized by bonding at a low temperature and the component could be operated at or above the bonding temperature. This paper presents research on LTTLP bonding of silver, gold, and copper. Sixteen solders with melting temperatures between 30Â° (85Â°F and 15TC (315T) were studied. Bond formation for each alloy on the three metals was studied by measuring the bond remelting temperature and its development time. Some mechanical shear strength data was also collected. The use of LTTLP bonding for die attach could be particularly advantageous for fragile or temperature sensitive components which require a good electrically and thermally conductive bond.