gebhart/patrepeval huggingface dataset:
Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience (2011)

Successful and consistent isolation of primary human hepatocytes remains a challenge for both cell-based therapeutics/transplantation and laboratory research. Several centres around the world have extensive experience in the isolation of human hepatocytes from non-diseased livers obtained from donor liver surplus to surgical requirement or at hepatic resection for tumours. These livers are an important but limited source of cells for therapy or research. The capacity to isolate cells from diseased liver tissue removed at transplantation would substantially increase availability of cells for research. However no studies comparing the outcome of human hepatocytes isolation from diseased and non-diseased livers presently exist. Here we report our experience isolating human hepatocytes from organ donors, non-diseased resected liver and cirrhotic tissue. We report the cell yields and functional qualities of cells isolated from the different types of liver and demonstrate that a single rigorous protocol allows the routine harvest of good quality primary hepatocytes from the most commonly accessible human liver tissue samples.
Theoretical Investigation on Feedback Control of Hybrid Rocket Engines (2019)

Despite the fact that hybrid propulsion offers significant benefits, it still suffers from some limitations such as the natural oxidizer to fuel ratio shift which induces variations of the engines’ performances while operating. To overcome that issue, Japan Aerospace Exploration Agency (JAXA) has been studying an innovative concept for several years based on the combination of controlled axial and radial oxidizer injections, called altering-intensity swirling-oxidizer-flow-type engine. This type of motor is theoretically capable of managing both the thrust and the oxidizer to fuel ratio independently and instantaneously by using a feedback control loop. To be effective, such engines would require in-flight instantaneous and precise thrust and an oxidizer to fuel ratio measurements as well as an adapted feedback control law. The purpose of this study is to investigate the effect of measurement errors on the engine control and to propose a regulation law suitable for these motors. Error propagation analysis and regulation law are developed from fundamental equations of hybrid motors and applied in a case where resistor-based sensors are used for fuel regression rate measurement. This study proves the theoretical feasibility of hybrid engines feedback control while providing some methods to design the engine and regression rate sensors depending on the mission requirements.
Outline of JUA clinical guidelines for benign prostatic hyperplasia (2011)

The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) for men with suspected BPH, which have been abridged and translated into English. This article is a shortened version of the English translation. The Guidelines were formulated on the basis of evidence retrieved from the PubMed database between 1995 and 2009, as well as other relevant sources. The target patients of these Guidelines are men with suspected BPH, and the target users are urologists. A mandatory assessment should include a medical history, a physical examination, the completion of symptom and quality of life questionnaires, urinalysis, prostate ultrasonography, measurement of serum prostate specific antigen and postvoid residual urine, and an uroflowmetry. Optional tests include a bladder diary, the measurement of serum creatinine, and upper urinary tract ultrasonography. Care should be taken to not overlook coexisting diseases such as an infection or malignancy that may obscure the diagnosis. Treatment should consist of conservative therapy or the use of medications such as α(1) -adrenoceptor antagonists, or both. The use of 5α-reductase inhibitors or anticholinergic agents should be considered in patients with an enlarged prostate (>30 mL) or overactive bladder symptoms (overactive bladder symptom score ≥ 6), respectively. Surgical intervention is indicated when non-surgical treatments fail to provide sufficient symptomatic relief and bladder outlet obstruction is highly suspected.
Clonal Propagation of Citrus from Somatic Callus Cultures1 (1974)

Abstract Isolated stem- and leaf-callus tissues of Citrus grandis (L.) Osbeck and C. sinensis , (L.) Osbeck, established in continuous culture, produced maximum number of shoot-buds in a treatment containing 0.25 mg/liter 6 benzylamino purine (BA) + 0.1 mg/liter naphthalineacetic acid (NAA). Callus-regenerated excised shoots produced shoot-buds from their cut ends in this treatment and roots in a treatment containing 0.1 or 0.5 mg/liter NAA. Numerous such rooted shoots developed into vigorous plants in potted soil.
Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis (2021)

Two nonapeptide natural products, amycolapeptins A (<b>1</b>) and B (<b>2</b>) with a 22-membered cyclic depsipeptide skeleton, β-hydroxytyrosine, and a highly modified side chain, which were not produced in a monoculture of the rare actinomycete <i>Amycolatopsis</i> sp. 26-4, were discovered in broth of its combined-culture with <i>Tsukamurella pulmonis</i> TP-B0596. The planar structures were elucidated by spectroscopic analyses (extensive 2D-NMR and MALDI-TOF MS/MS). The absolute configurations of component amino acids were unambiguously determined by the highly sensitive advanced Marfey's method we recently developed. Additionally, the structures of unstable/unusual moieties were corroborated by chemical synthesis and CD analysis.
A convenient method for the preparation of 3-(2-pyridyl)triazolo[1,5-a]pyridine (L). Crystal structures of L and [CuL2(OH2)2][NO3]2 (1994)

The compound 3-(2-pyridyl)triazolo[1,5-a]pyridine (L) was synthesized under mild conditions by refluxing equimolar amounts of hydrazine and di-2-pyridyl ketone in methanol–water. It has been characterized by X-ray diffraction and used as a ligand in two metal complexes, [ML2(OH2)2][NO3]2(M = Cu or Co). The crystal structure of the copper derivative, which is the first example of a triazolopyridine complex, has also been determined.
Highly efficient one-pot multi-component synthesis of α-aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis (2013)

A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of α-aminophosphonate derivatives (4a–x) in excellent yields. The α-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.
Enteric‐coated mycophenolate sodium delivers bioequivalent MPA exposure compared with mycophenolate mofetil (2005)

Mycophenolic acid (MPA), the active moiety of mycophenolate mofetil (MMF), is routinely used as an adjunct immunosuppressant therapy in renal transplantation. Although highly effective, MMF therapy is associated with significant gastrointestinal adverse effects. Enteric-coated mycophenolate sodium (EC-MPS) is an advanced formulation delivering MPA. The enteric coat dissolves at pH > 5 allowing for MPA delivery in the small intestine. A single-center, open-label, randomized, three-way crossover study of 24 stable Caucasian renal transplant patients receiving cyclosporine-based immunosuppression, compared the relative bioavailability of two EC-MPS doses (640 and 720 mg) with MMF (1000 mg). Both EC-MPS doses delivered bioequivalent mean MPA exposure (AUC(0-infinity)) compared with 1000 mg MMF: 60.7 microg h/mL for 640 mg EC-MPS, 66.5 microg h/mL for 720 mg EC-MPS, and 63.7 microg h/mL for 1000 mg MMF. Median t(max) was significantly delayed for both EC-MPS doses compared with MMF (2.0 h vs. 0.75 h, respectively; p < 0.01), consistent with a functional enteric coating of EC-MPS. Furthermore, both EC-MPS doses were bioequivalent to 1000 mg MMF for AUC and C(max) for mycophenolic acid glucuronide. All three treatments were well tolerated. The EC-MPS 720 mg dose most closely approximated the MPA exposure of 1000 mg MMF and was selected for subsequent phase III studies.
Desalter Acidification Additives and Their Potential Impacts on Crude Units (2008)

Abstract The increased challenges refiners face with frequent crude changes, processing of new opportunity crudes, and limited mechanical systems have resulted in difficult operations that require alternative treatment methods. In terms of chemical treatment, one potential option to alleviate difficult desalter operations is the use of acidification aids. This paper will cover the key drivers for desalter acidification, the benefits from this approach and the downstream effects (e.g., corrosion, fouling) from the application of this type of technology. Also discussed will be the different type of chemistries, reactions, the fate of acids in the desalting operation, and their potential impacts on downstream operations. Field experience and observations from acidification programs will be presented and discussed.
India and its pluralistic health system – a new philosophy for Universal Health Coverage (2022)

In this article we attempt to put forth insights into using traditional medicine (TM) systems to achieve Universal Health Coverage (UHC). We discuss the need for reimagining India's health system and the importance of an inclusive approach for UHC. We comprehend the challenges with appropriate use of TM systems and the lessons from international experience of integrating TM systems. We highlight the pathways for better utilization of TM systems for UHC in India.
Selective Removal of Uranium from Rare Earth Leachates via Magnetic Solid-Phase Extraction Using Schiff Base Ligands (2018)

This study highlights a new type of extraction procedure combining a magnetic solid-phase support and a Schiff base ligand for the removal of uranium from rare earth leachates. After synthesizing and characterizing three Schiff base ligands (CH3Salen, H2Salophen, and MeOSalophen), they were combined with magnetic nanoparticles and assessed for the selective extraction of uranium. To optimize extraction, the effects of parameters such as the pH, the mass of the ligand, and extraction time, were explored. The maximum adsorption capacity for U(VI) using the magnetic MeOSalophen Schiff base was 63 ± 3 mg g–1 at pH = 6 with 25 mg of extracting agent for a contact period of 24 h. An acceptable extraction of U(VI) was also observed in more acidic conditions with a shorter extraction period. The magnetic ligand has shown a high selectivity toward U(VI) over a number of metals in a real rare earth element leaching solution.
The function of salivary proteins and the regulation of their secretion by salivary glands (1998)

Salivary glycoproteins give saliva its characteristic physical properties and enable it to form a thin film over hard and soft tissues in the mouth. Oral health and homeostasis are dependent upon the functions performed by the salivary film and most of these functions, including lubrication, barrier function and microbial interactions, are in turn dependent upon salivary proteins. Some salivary proteins appear to fulfil more than one function and some functions are performed by a number of different proteins. There are relatively great variations in amounts of different proteins present in salivas from different subjects. However, subjects with low levels of particular proteins do not appear to suffer terms of oral health and this may be due to functional compensation by other proteins. Salivary protein secretion by salivary glands is dependent upon stimuli mediated by sympathetic and parasympathetic nerves and both acinar and ductal cells make a contribution to protein secretion. In addition to the well-characterized storage granule exocytosis pathway of protein secretion, salivary cells can secrete proteins by vesi cular, non-storage granule pathways. These include direct secretion of newly synthesized proteins to saliva and to the glandular matrix and to circulation, and transcytosis of polymeric immunoglobulin A into saliva following secretion by glandular plasma cells. Recent data indicate that all ofthese pathways are subject to regulation by autonomic ner ves. Resynthesis of some salivary proteins following secretion also shows a dependency upon nerve-mediated stimuli. The distal intracellular mechanisms coupling stimulation to synthesis are uncertain although the proximal events appear to be similar to those coupling stimulation to exocytosis. The synthesis of some salivary proteins can be upregulated by cy-tokines released from inflammatory cells and this can lead to increased salivary levels of antimicrobial proteins including lactoferrin and immunoglobulin A. Biomedical Reviews 1998; 9: 3-15.
Experimental Investigation of Concrete using Sugarcane Baggase Ash as a Partial Replacement for Cement (2021)

Abstract. Cement being a major contributor to carbon emission needs a revolution in its production or modification to the existing cement. One such way to reduce cement usage is to replace the cementitious compound with a suitable material that does not alter the original purpose of cement in concrete. The sugarcane bagasse ashes (SCBA), which are ashes from biomass burning, are found to act as supplementary cementitious material. Moreover, studies were conducted to relate the strength and durability of concrete by the percentage of replacement of sugarcane bagasse ash to cement. The studies revealed that the SCBA imparts more strength to cement at 10% replacement when compared to 20% replacement. However, this study is intended to use 20% of SCBA replacement in cement by adding silica fume. Concrete being mainly reinforced with steel has the problem of corrosion. To overcome the problem of corrosion as well as to reduce the use of cement and to attain the compressive strength of 10% replacement of SCBA. This experiment is intended to analyze the behavior of concrete up to 20% replacement of SCBA with silica fume at different concentrations such as 0%,5%,10%,15%.
Asynchronous transfer mode (ATM) : technical overview (1995)

Written for computer professionals who have a basic understanding of communications, this book offers a broad overview of the emerging technologies of very high-speed data and voice communications. Covers the principles of high-speed networking; fiber optical technology and optical networks; local area networks; metropolitan area networks; high-speed packet switches; and high-speed cell switching. For computer professionals interested in the fields of data communications and voice networking.
Potential Second-Hits in Hereditary Hemorrhagic Telangiectasia (2020)

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder that presents with telangiectases in skin and mucosae, and arteriovenous malformations (AVMs) in internal organs such as lungs, liver, and brain. Mutations in <i>ENG</i> (endoglin), <i>ACVRL1</i> (ALK1), and <i>MADH4</i> (Smad4) genes account for over 95% of HHT. Localized telangiectases and AVMs are present in different organs, with frequencies which differ among affected individuals. By itself, HHT gene heterozygosity does not account for the focal nature and varying presentation of the vascular lesions leading to the hypothesis of a "second-hit" that triggers the lesions. Accumulating research has identified a variety of triggers that may synergize with HHT gene heterozygosity to generate the vascular lesions. Among the postulated second-hits are: mechanical trauma, light, inflammation, vascular injury, angiogenic stimuli, shear stress, modifier genes, and somatic mutations in the wildtype HHT gene allele. The aim of this review is to summarize these triggers, as well as the functional mechanisms involved.
Supplementary Data 1 from Revised Risk Estimation and Treatment Stratification of Low- and Intermediate-Risk Neuroblastoma Patients by Integrating Clinical and Molecular Prognostic Markers (2023)

&lt;p&gt;Supplementary Data 1. This supplementary data comprises a step-by-step description on how our gene-expression based classification models were generated and validated&lt;/p&gt;
Pargyline reduces renal damage associated with ischaemia-reperfusion and cyclosporin (2010)

It appears that the blockage of ROS produced by MAO and subsequent cell death might be an effective protective strategy against IFTA progression.
Smart energy coordination of a hybrid wind/ PV with battery storage connected to grid (2019)

This study presents a smart power strategy coordination for optimal electricity supply. It aims to coordinate the energy flow on the electrical system for a residential application in the southern area of the African continent, in conjunction with an intelligent demand management control strategy. It has been observed that there is a potential for renewable energy resources that can enhance the energy and development of the African continent if used efficiently. In addition, the continent is suffering from several energy crises, which could be resolved by appropriate energy control approaches. It has been observed that incorporating an autonomous smart strategy that can coordinate a hybrid energy supply for a residential energy demand could improve the power grid performance of the Southern African region. In this paper, a smart strategy that develops a dynamic real‐time energy structure control is proposed. This approach uses the ability of smart metering to create a flexible communication control strategy (FCCS), which will manage the demand and the supply of energy. It ensures the consumer's optimal power supply while ensuring stability and good performance on the utility side.
Aetiology, clinical features, diagnostic studies, and outcomes of community-acquired pneumonia in kidney transplant recipients admitted to hospital: a multicentre retrospective French cohort study (2022)

CAP episodes occurred in kidney transplant recipients with a long history of immunosuppressive drug exposure. Diagnostic studies identified a microorganism in more than one-third of CAP episodes, including drug-resistant and opportunistic pathogens.
"Download for Free" (2004)

In a monopoly setting where consumers cannot observe the quality of the product we show that free samples which are of a lower quality than the marketed digital goods are used together with high prices as signals for a superior quality if the number of informed consumers is small and if the di®erence between the high and the low quality is not too small. Social welfare is higher, if the monopolist uses also free samples as signals, compared to a situation where he is restricted to pure price signalling. Both, the monopolist and consumers bene¯t from the additional signal.
The protective effects of taurine against renal damage by salt loading in Dahl salt-sensitive rats (2002)

The protective effects of taurine supplementation against renal damage induced by salt loading in DS rats may be attributed to the suppression of LOX-1, probably through its antioxidant effects.
Exploring Work Choices to Slow Early Labour Force Exit of Mature Aged Australians: Results from the Transitional Employment Survey (2006)

As the population ages on a global scale, older workers have the propensity to become a significant economic force for the future of Australia. However, OECD and ABS reports indicate that work conditions may be incompatible with the needs of mature aged workers, thus early retirement is common. Transitional employment offers potential solutions for the ageing workforce to remain engaged in the workforce by enabling some financial independence and reduced stressors in the workplace. This study is from the first year data of an ARC funded Industry linkage grant concerning older workers. A qualitative study using an Australia wide online survey solicited aspirations of older workers regarding transitional employment options. The results indicate that the majority of workers responded favourably to transitional employment. The findings provide useful data to map the possible confounding effect of education level and job types on preferences for transitional work by older workers.
Combined Use of the Endoscope and Microscope in Anterior Skull Base Tumor Surgery (2007)

Purpose: Tumors of the anterior skull base are an interdisciplinary challenge. Especially meningiomas and chordomas frequently destroy the osseus skull base and involve the sinus region. Different transfacial and transcranial approaches were recommended to manage these lesions. The aim of our study was to evaluate the advantage of combined use of endoscopic and microscopic techniques in the anterior skull base surgery.
Coded aperture correlation holography (COACH) with a superior lateral resolution of FINCH and axial resolution of conventional direct imaging systems (2021)

Fresnel incoherent correlation holography (FINCH) is a self-interference incoherent digital holography technique. It possesses a higher lateral resolution than an equivalent incoherent imaging system. However, FINCH has lower axial resolution than the direct imaging systems with the same numerical aperture. A decade after the FINCH invention, a different incoherent holographic method named coded aperture correlation holography (COACH) was developed with improved axial resolution but with the same lateral resolution as direct imaging. In this study, we propose and demonstrate a variant of COACH called coded aperture with FINCH intensity responses (CAFIR) with an improved lateral resolution that is similar to the FINCH system while maintaining its high axial resolution similar to the direct imaging system. CAFIR is implemented with coded phase masks to generate an ensemble of quasi-randomly distributed FINCH-like responses. Point spread holograms and object holograms are recorded under identical conditions, and they are cross-correlated to obtain the image reconstruction. Imaging of a multiplane object is studied to compare the axial resolution of CAFIR with FINCH and direct imaging systems.
Topologically-aware overlay construction and server selection (2003)

A number of large-scale distributed Internet applications could potentially benefit from some level of knowledge about the relative proximity between its participating host nodes. For example, the performance of large overlay networks could be improved if the application-level connectivity between the nodes in these networks is congruent with the underlying IP-level topology. Similarly, in the case of replicated Web content, client nodes could use topological information in selecting one of multiple available servers. For such applications, one need not find the optimal solution in order to achieve significant practical benefits. Thus, these applications, and presumably others like them, do not require exact topological information and can instead use sufficiently informative hints about the relative positions of Internet hosts. In this paper, we present a binning scheme whereby nodes partition themselves into bins such that nodes that fall within a given bin are relatively close to one another in terms of network latency. Our binning strategy is simple (requiring minimal support from any measurement infrastructure), scalable (requiring no form of global knowledge, each node only needs knowledge of a small number of well-known landmark nodes) and completely distributed (requiring no communication or cooperation between the nodes being binned). We apply this binning strategy to the two applications mentioned above: overlay network construction and server selection. We test our binning strategy and its application using simulation and Internet measurement traces. Our results indicate that the performance of these applications can be significantly improved by even the rather coarse-grained knowledge of topology offered by our binning scheme.