gebhart/patrepeval huggingface dataset:
Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin After Single and Multiple Doses in Healthy Volunteers (2004)

This study describes a pharmacokinetic (PK) model to account for serum recombinant human erythropoietin (rHuEpo) concentrations in healthy volunteers following intravenous (IV) and subcutaneous (SC) dosing; it also characterizes the pharmacodynamics (PD) of SC rHuEpo effects on reticulocytes, red blood cells (RBC), and hemoglobin (Hb) in blood. Data were obtained from 4 clinical studies carried out in healthy volunteers. Epoetin alfa (rHuEpo) was administered as 5 single IV doses ranging from 10 to 500 IU/kg, as 8 single SC doses ranging from 300 to 2400 IU/kg, and as 2 multiple SC dosage regimens (150 IU/kg/3 times a week [tiw] and 600 IU/kg/wk). A dual-absorption rate model (fast zero-order and slow first-order inputs) with nonlinear disposition characterized the PK of SC rHuEpo. A high K(m) value was obtained indicating that clearance was mildly nonlinear. Absorption was slow (t(max) approximately 24 hours), and the bioavailability of SC rHuEpo increased with dose (ranging from 46%-100%). A catenary cell production and loss model with a feedback down regulation component was used to fit the reticulocyte data yielding estimates of the stimulatory capacity (S(max)), sensitivity (SC(50)), and life span parameters. These parameters were used for simulations of RBC and Hb profiles. An SC(50) of 27 to 61 IU/L was estimated indicating that low physiological plasma rHuEpo concentrations were sufficient to produce pharmacological effects. No marked sex-dependent differences in clinical responses to rHuEpo therapy were found despite baseline differences. Realistic pharmacokinetic and physiological models accounted for clinical responses from a wide array of dosing conditions with rHuEpo. The rationale for greater efficacy of SC administration of rHuEpo compared to IV was ascertained.
The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood (2009)

Wine chemical compositions, which result from a complex interplay between environmental factors, genetic factors, and viticultural practices, have mostly been studied using targeted analyses of selected families of metabolites. Detailed studies have particularly concerned volatile and polyphenolic compounds because of their acknowledged roles in the organoleptic and therapeutic properties. However, we show that an unprecedented chemical diversity of wine composition can be unraveled through a nontargeted approach by ultrahigh-resolution mass spectrometry, which provides an instantaneous image of complex interacting processes, not easily or possibly resolvable into their unambiguous individual contributions. In particular, the statistical analysis of a series of barrel-aged wines revealed that 10-year-old wines still express a metabologeographic signature of the forest location where oaks of the barrel in which they were aged have grown.
The automated desk (1981)

The Automated Desk is an online, spatial interface to a time-shared computer utility. It supports a user in organizing, locating, and handling computerized information and tools. Naive computer users benefit from the ability to use the power of an operating system without knowing operating system commands. Experienced programmers benefit from the ability to “browse” a large number of “virtual terminals,” each running instances of various software programs. All users benefit from the ability to access computer-resident information while retaining the familiar visual orientation of the office desk. The user sees his “desk top” through an intelligent display terminal that is connected to a host computer. The desk top is a large flat surface about 100 times the size of an ordinary desk top. On it, the user can place objects in groupings that are meaningful to him. Processes can be associated with these objects to perform any online information handling function. The Automated Desk is a derivative of the Spatial Data Management System (SDMS) implemented by Computer Corporation of America. In the Automated Desk, the essential SDMS concepts of spatial organization and pictorial identification are implemented in simple ways on equipment of modest cost. The objective of the Automated Desk is to put key SDMS-like capabilities into an inexpensive product that runs on widely-available equipment. It is intended for widespread use in practical applications.
Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells (2012)

Anergy is induced in T cells as a consequence of a partial or suboptimal stimulation. Anergic T cells become unresponsive and fail to proliferate and produce cytokines. We had previously shown that in anergic CD4(+) T cells, Ikaros participates in the transcriptional repression of the Il2 gene by recruiting histone deacetylases that cause core histone deacetylation at the Il2 promoter. Here we show that deacetylation at the Il2 promoter is the initial step in a process that leads to the stable silencing of the Il2 gene transcription in anergic T cells. We have found that anergy-induced deacetylation of the Il2 promoter permits binding of the histone methyl-transferase Suv39H1, which trimethylates lysine-9 of histone H3 (Me3H3-K9). Furthermore, the establishment of the Me3H3-K9 mark allows the recruitment of the heterochromatin protein HP1, allowing the silenced Il2 loci to reposition close to heterochromatin-rich regions. Our results indicate that silencing of Il2 transcription in anergic T cells is attained through a series of epigenetic changes that involve the establishment of repressive marks and the subsequent nuclear repositioning of the Il2 loci, which become juxtaposed to transcriptionally silent regions. This mechanism may account for the stable nature of the inhibition of IL-2 production in anergic cells.
Exploiting relationships for domain-independent data cleaning (2005)

In this paper, we address the problem of reference disambiguation. Specifically, we consider a situation where entities in the database are referred to using descriptions (e.g., a set of instantiated attributes). The objective of reference disambiguation is to identify the unique entity to which each description corresponds. The key difference between the approach we propose (called RelDC) and the traditional techniques is that RelDC analyzes not only object features but also inter-object relationships to improve the disambiguation quality. Our extensive experiments over two real datasets and over synthetic datasets show that analysis of relationships significantly improves quality of the result.
Synthesis and Spectral Characteristics of Gold Nanoparticles Labelled with Fluorescein Sodium (2011)

The biological application of labeled nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of human cancers. Gold nanoparticles (GNPs) have been prepared via wet chemical method. Fluorescein capped gold nanoparticles have been prepared by a reduction of the HAuCl4 in boiling fluorescein sodium solution. The results indicated that the spectrum exhibits one curve with two absorption bands at δmax.= 496, 585 nm, which corresponds to the absorption spectra of both fluorescein and GNPs, respectively. TEM, UV-Visible, fluorescence and IR spectroscopy confirm the formation of GNPs and fluorescein capped GNPs. These fluorescein capped gold nanoparticles can be used in labeling DNA and other imperative biological molecules.
Regioselectivity in lateral deprotonation of an isoxazolecarboxamide of (S)‐prolinol. Conformational correlation by crystal structure solid state solution 13C NMR (1987)

Abstract The conformation at the amide functional group in 3,5‐dimethylisoxazole‐4‐( S ‐2′‐hydroxymethyl‐ N ‐pyrrolidino) carboxamide (1) has been determined by a single crystal X‐ray determination. The 13 C nmr in both deuteriochloroform solution and solid state show close agreement. The metalation behaviour of the amide is dependent upon the substitution on the 2′‐hydroxymethyl moiety. Dianion studies indicate C‐5 lateral metalation under both thermodynamic and kinetic conditions. Protection of this substituent as the methyl ether, 2 , gives rise to predominant C‐3 lateral metalation under kinetic conditions and C‐5 lateral metalation on equilibration. These observations can be explained using the Ireland‐Evans model for chelation directed deprotonation.
Polarization: Polarization-Dependent Harmonic Generation in Photonic Crystal Fibers (2003)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Fiorenzo G. Omenetto, Anatoly Efimov, A. J. Taylor, J. C. Knight, W. Wadsworth, and P. St J. Russell, "Polarization: Polarization-Dependent Harmonic Generation in Photonic Crystal Fibers," Optics & Photonics News 14(12), 36-36 (2003) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Organic small molecule semiconducting chromophores for use in organic electronic devices (2023)

Small organic molecule semi-conducting chromophores containing a pyridalthiadiazole, pyridaloxadiazole, or pyridaltriazole core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic small molecule solar cells and transistors.
Using CAP Dimensionality for Service and User Allocation for Optical Access Networks (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. B. Othman, X. Zhang, J. B. Jensen, and I. T. Monroy, "Using CAP Dimensionality for Service and User Allocation for Optical Access Networks," in Asia Communications and Photonics Conference, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper AS3C.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Storyboarding (2006)

Storyboarding is a common technique in HCI and design for demonstrating system interfaces and contexts of use. Despite its recognized benefits, novice designers still encounter challenges in the creation of storyboards. Furthermore, as computing becomes increasingly integrated into the environment, blurring the distinction between the system and its surrounding context, it is imperative to depict context explicitly in storyboards. In this paper, we present two formative studies designed to uncover the important elements of storyboards. These elements include the use of text, inclusion of people, level of detail, number of panels, and representation of the passage of time. We further present an empirical study to assess the effects of these elements on the understanding and enjoyment of storyboard consumers. Finally, we demonstrate how these guidelines were successfully used in an undergraduate HCI class.
Thrombin generation, a function test of the haemostaticthrombotic system (2006)

By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evidence is growing that the parameters of the thrombogram, and notably the area under the curve (endogenous thrombin potential, ETP), are useful in assessing bleeding- or thrombotic risk and its modification by antithrombotic- or haemostatic treatment. Available data strongly suggest that conditions (congenital, acquired, drug-induced) that increase TG all cause a thrombotic tendency and that conditions that decrease TG prevent thrombosis but, beyond a limit, cause bleeding. Diminution of TG is a common denominator of all antithrombotic treatment, including anti-platelet drugs. The thrombogram can also be used as a tool in the search for new antithrombotics and reflects the haemorrhagic or thrombotic side effects of other drugs (e.g. oral contraceptives). The thrombogram thus is a promising new approach to clinical management of bleeding and thrombotic disease as well as a tool in drug research and epidemiology. Our experience at this moment is insufficient, however, to already clearly define its limits.
Cutaneous T-cell Lymphoma and Concomitant Atopic Dermatitis Responding to Dupilumab (2020)

Cutaneous T-cell lymphoma (CTCL) represents a diagnostic challenge because of its large symptomatic overlap with other common skin conditions such as atopic dermatitis (AD) and psoriasis. Dupilumab has offered promising results in AD treatment; however, concerns exist that its use may exacerbate undiagnosed CTCL. We present a patient with CTCL and concomitant AD who experienced improvement in both CTCL blood involvement and AD following the addition of dupilumab therapy.
A review of the impact on the ecosystem after ionizing irradiation: wildlife population (2020)

The initial intense radiation in these areas has gradually begun to decrease but still remains high. Adaptation to radiation is evident and the ecosystems have dynamically changed from the periods immediately after the accidents to the present day. Understanding the molecular mechanisms that allow the adaptation and recovery of wildlife to chronic radiation challenges would aid in future attempts at ecosystem remediation in the wake of such incidents.
Characterization of the Developing Lacunocanalicular Network During Fracture Repair (2021)

Fracture repair is a normal physiological response to bone injury. During the process of bony callus formation, a lacunocanalicular network (LCN) is formed de novo that evolves with callus remodeling. Our aim was the longitudinal assessment of the development and evolution of the LCN during fracture repair. To this end, 45 adult wild-type C57BL/6 mice underwent closed tibial fracture surgery. Fractured and intact contralateral tibias were harvested after 2, 3, and 6 weeks of bone healing (<i>n</i> = 15/group). High-resolution micro-computed tomography (μCT) and deconvolution microscopy (DV) approaches were applied to quantify lacunar number density from the calluses and intact bone. On histological sections, Goldner's trichrome staining was used to assess lacunar occupancy, fluorescein isothiocyanate staining to visualize the canalicular network, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) staining to examine osteocyte apoptosis. Analysis of μCT scans showed progressive decreases in mean lacuna volume over time (-27% 2-3 weeks; -13% 3-6 weeks). Lacunar number density increased considerably between 2 and 3 weeks (+156%). Correlation analysis was performed, showing a positive linear relationship between canalicular number density and trabecular thickness (<i>R</i> <sup>2</sup> = 0.56, <i>p</i> < 0.001) and an inverse relationship between mean lacuna volume and trabecular thickness (<i>R</i> <sup>2</sup> = 0.57, <i>p</i> < 0.001). Histology showed increases in canalicular number density over time (+22% 2-3 weeks, +51% 3-6 weeks). Lacunar occupancy in new bone of the callus was high (>90%), but the old cortical bone within the fracture site appeared necrotic as it underwent resorption. In conclusion, our data shows a progressive increase in the complexity of the LCN over time during fracture healing and demonstrates that this network is initiated during the early stages of repair. Further studies are needed to address the functional importance of osteocytes in bone healing, particularly in detecting and translating the effects of micromotion in the fracture. © 2021 The Authors. <i>JBMR Plus</i> published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
ChemInform Abstract: Palladium‐Catalyzed Double Substitution of 3‐Aryl‐2‐fluoroallyl Acetates with Phenols via C—F Bond Activation. (2014)

Abstract Alkyl‐substituted 2‐fluoroallyl acetates do not provide the desired products.
Medicare/Medicaid Insurance Status Is Associated With Reduced Lower Bilateral Knee Arthroplasty Utilization and Higher Complication Rates (2022)

Whether to undergo bilateral total knee arthroplasty (BTKA) depends on patient and surgeon preferences. We used the National Inpatient Sample to compare temporal trends in BTKA utilization and in-hospital complication rates among TKA patients ≥50 with Medicare/Medicaid versus private insurance from 2007 to 2016. We used multivariable logistic regression to assess the association between insurance type and trends in utilization and complication rates adjusting for individual-, hospital-, and community-level covariates, using unilateral TKA (UTKA) for reference. Discharge weights were used for nationwide estimates. About 132,400 (49.5%) Medicare/Medicaid patients and 135,046 (50.5%) privately insured patients underwent BTKA. Among UTKA patients, 62.7% had Medicare/Medicaid, and 37.3% had private insurance. Over the study period, BTKA utilization rate decreased from 7.18% to 5.63% among privately insured patients and from 4.59% to 3.13% among Medicaid/Medicare patients (P trend difference <0.0001). In multivariable analysis, Medicare/Medicaid patients were less likely to receive BTKA than privately insured patients. Although Medicare/Medicaid patients were more likely to develop in-hospital complications after UTKA (adjusted odds ratio, 1.06; 95% confidence interval, 1.002 to 1.12; P = 0.04), this relationship was not statistically significant for BTKAs. In this nationwide sample of TKA patients, BTKA utilization rate was higher in privately insured patients compared with Medicare/Medicaid patients. Furthermore, privately insured patients had lower in-hospital complication rates than Medicare/Medicaid patients.
AN INSIGHT INTO THE IMPACT OF ARABLE FARMING ON IRISH BIODIVERSITY: A SCARCITY OF STUDIES HINDERS A RIGOROUS ASSESSMENT (2008)

Martin O'Brien, Charles Spillane, Conor Meade, Ewen Mullins, AN INSIGHT INTO THE IMPACT OF ARABLE FARMING ON IRISH BIODIVERSITY: A SCARCITY OF STUDIES HINDERS A RIGOROUS ASSESSMENT, Biology and Environment: Proceedings of the Royal Irish Academy, Vol. 108B, No. 2 (September 2008), pp. 97-108
Structural characterization of natural UO2 at pressures up to 82 GPa and temperatures up to 2200 K (2008)

International audience
Characteristics of aldehydes: concentrations, sources, and exposures for indoor and outdoor residential microenvironments (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacteristics of aldehydes: concentrations, sources, and exposures for indoor and outdoor residential microenvironmentsJunfeng. Zhang, Paul J. Lioy, and Qingci. HeCite this: Environ. Sci. Technol. 1994, 28, 1, 146–152Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/es00050a020https://doi.org/10.1021/es00050a020research-articleACS PublicationsRequest reuse permissionsArticle Views1016Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses (93.23) (2009)

Abstract B-1 and marginal zone (MZ) B cells produce natural antibodies, make antibody responses to microbial pathogens, and contribute to autoimmunity. Although the delta isoform of the phosphoinositide 3-kinase p110 catalytic subunit (p110δ) is essential for development of these innate-like B cells, its role in mature B-1 and MZ B cells is not known. Using IC87114, a selective inhibitor of p110δ activity, we show that p110δ is important for B-1 and MZ B cell responses to anti-Ig antibodies, the Toll-like receptor (TLR) ligands LPS and CpG DNA, and the chemoattractants CXCL13 and sphingosine 1-phosphate. Moreover, we found that TLR-induced antibody responses by B-1 and MZ B cells, as well as the localization of MZ B cells in the spleen, depend on p110δ activity. Finally, we show that in vivo production of both protective and self-reactive natural antibodies requires p110δ and that p110δ inhibitors can reduce in vivo autoantibody responses. Thus targeting p110δ may be a novel approach for regulating innate-like B cells and treating antibody-mediated autoimmune diseases. Supported by a grant to M.R.G. from the Canadian Institutes of Health Research, by NIH grants to J.L.W., and a grant to J.L.W. from the Leducq Foundation.
P3‐424: Diet‐induced hyperhomocysteinemia increases amyloid‐beta levels in a mouse model of Alzheimer's disease by modulating the endoplasmatic reticulum stressor response (2008)

High plasma homocysteine levels have been recognized as a risk factor for Alzheimer's disease (AD). However, the underlying mechanism is still elusive. Previous in vitro studies have demonstrated that homocysteine, by increasing the expression levels of Herp--an endoplasmatic reticulum stressor protein, elevates amyloid-beta formation. In the current study, we tested the hypothesis that in vivo high homocysteine levels may increase brain amyloid-beta levels and deposition whereby modulating Herp expression. To this end hyperhomocysteinemia was induced by feeding Tg2576 mice, a transgenic mouse model over-expressing the human APP Swedish mutation, with a methionine-enriched diet. After 7 months on the diet, Tg2576 and their control mice were sacrificed at the age of 15 months and their brains were harvested. One hemisphere of the brain was used for amyloid-beta immunostaining; the other one went through two-step extraction (RIPA and formic acid) for ELISA and western blot analyses. Compared to control group, diet-treated Tg2576 mice have higher level of homocysteine, Herp protein, and amyloid-beta40/42 in the formic acid extraction of both cortex and hippocampus. Immunostaining studies also showed that diet-treated Tg2576 mice had more amyloid-beta plaques deposits than control mice on regular chow diet. By contrast, no significant difference in total APP, beta- or alpha-secretase levels were observed between the diet-treated mice and control group. We conclude that diet-induced hyperhomocysteinemia, significantly increases amyloid-beta levels and deposition in the Tg2576 mice whereby modulating the expression levels of Herp protein. Given the unchanged total APP level and the unaltered alpha- and beta secretase pathways, we conclude that Herp modulates in vivo the pro-amyloidotic effect of hyperhomocysteinemia by interfering with APP proteolytic pathways after its beta cleavage (e.g. gamma-secretase).
Durability of Hearing Preservation after Cochlear Implantation with Conventional‐Length Electrodes and Scala Tympani Insertion (2016)

To control for hearing loss associated with interscalar excursion during cochlear implantation, the present study evaluated patients only with conventional electrode arrays located entirely within the scala tympani. In this group, the style of electrode array may influence residual hearing preservation over time.
Pédagogie active basée sur la pédagogie du projet et sur l'utilisation d'Espace Numérique d'Apprentissage (2009)

International audience