gebhart/patrepeval huggingface dataset:
Survival Analysis for Multimode Ablation Using Self-Adapted Deep Learning Network Based on Multisource Features (2023)

Novel multimode thermal therapy by freezing before radio-frequency heating has achieved a desirable therapeutic effect in liver cancer. Compared with surgical resection, ablation treatment has a relatively high risk of tumor recurrence. To monitor tumor progression after ablation, we developed a novel survival analysis framework for survival prediction and efficacy assessment. We extracted preoperative and postoperative MRI radiomics features and vision transformer-based deep learning features. We also combined the immune features extracted from peripheral blood immune responses using flow cytometry and routine blood tests before and after treatment. We selected features using random survival forest and improved the deep Cox mixture (DCM) for survival analysis. To properly accommodate multitype input features, we proposed a self-adapted fully connected layer for locally and globally representing features. We evaluated the method using our clinical dataset. Of note, the immune features rank the highest feature importance and contribute significantly to the prediction accuracy. The results showed a promising C$^{\mathit{td}}$-index of 0.885 $\pm$ 0.040 and an integrated Brier score of 0.041 $\pm$ 0.014, which outperformed state-of-the-art method combinations of survival prediction. For each patient, individual survival probability was accurately predicted over time, which provided clinicians with trustable prognosis suggestions.
In vitro fusion of Acanthamoeba phagolysosomes. III. Evidence that cyclic nucleotides and vacuole subpopulations respectively control the rate and the extent of vacuole fusion in Acanthamoeba homogenates. (1980)

Fusion of phagolysosomes has been previously demonstrated to occur during the incubation of phagolysosome-containing homogenates of Acanthamoeba (Oates and Touster, 1978, J. Cell Biol. 79:217-234). Further studies on this system have shown that methylxanthines (0.2 mM) and/or cAMP (0.5-1 mM) markedly accelerate the average rate, but not the extent, of the in vitro phagolysosome fusion process. Adenosine, 5'-AMP, and ADP (0.5-1 mM) were without effect. ATP (0.5-1 mM) caused variable stimulation, whereas beta, gamma-methylene-ATP (1 mM) caused pronounced inhibition, as did GTP (1 mM) and cGMP (1 mM). Stimulation by 3-isobutyl-1-methylxanthine was blocked by GTP, but not by ATP or cAMP. These results indicate that the rate of phagolysosome fusion in Acanthamoeba homogenates may be regulated by cyclic nucleotides, with enhancement of the fusion rate by cAMP and inhibition of the rate by cGMP. The extent of the reaction increased spontaneously and markedly during the first few hours after preparation of the homogenates. This activation appears to be because of a slow conversion of a significant fraction of the vacuole population from a fusion-incompetent to a fusion-competent, cyclic nucleotide-sensitive state.
Performance Comparison of Algorithms for FindingTranscription Factor Binding Sites. (2003)

We compare the accuracy of three motif-finding algorithms for the discovery of novel transcription factor binding sites among co-regulated genes. One of the algorithms (YMF) uses a motif model tailored for binding sites and an enumerative search of the mo- tif space, while the other two (MEME and AlignA CE) use a more general motif model and local search techniques. The comparison is done on synthetic data with planted motifs, as well as on real data sets of co-regulated genes from the yeast S. cerevisiae. More often than not, the enumerative algorithm is found to be more accurate than the other two on the yeast data sets, though there is a noticeable exclusivity in the accuracy of the different algorithms. The experiments on synthetic data reveal, not surprisingly, that each algorithm outperforms the others when motifs are planted according to its motif model.
Determination of Mercury with s -Diphenylcarbazide (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Mercury with s -DiphenylcarbazideF. W. Laird and Sister Alonza SmithCite this: Ind. Eng. Chem. Anal. Ed. 1938, 10, 10, 576–578Publication Date (Print):October 1, 1938Publication History Published online1 May 2002Published inissue 1 October 1938https://pubs.acs.org/doi/10.1021/ac50126a002https://doi.org/10.1021/ac50126a002research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Proprioceptive localilzatilon for a quadrupedal robot on known terrain (2007)

We present a novel method for the localization of a legged robot on known terrain using only proprioceptive sensors such as joint encoders and an inertial measurement unit. In contrast to other proprioceptive pose estimation techniques, this method allows for global localization (i.e., localization with large initial uncertainty) without the use of exteroceptive sensors. This is made possible by establishing a measurement model based on the feasibility of putative poses on known terrain given observed joint angles and attitude measurements. Results are shown that demonstrate that the method performs better than dead-reckoning, and is also able to perform global localization from large initial uncertainty
Further Relaxations of the Semidefinite Programming Approach to Sensor Network Localization (2008)

Recently, a semidefinite programming (SDP) relaxation approach has been proposed to solve the sensor network localization problem. Although it achieves high accuracy in estimating the sensor locations, the speed of the SDP approach is not satisfactory for practical applications. In this paper we propose methods to further relax the SDP relaxation, more precisely, to relax the single semidefinite matrix cone into a set of small-size semidefinite submatrix cones, which we call a sub-SDP (SSDP) approach. We present two such relaxations. Although they are weaker than the original SDP relaxation, they retain the key theoretical property, and numerical experiments show that they are both efficient and accurate. The speed of the SSDP is even faster than that of other approaches based on weaker relaxations. The SSDP approach may also pave a way to efficiently solving general SDP problems without sacrificing the solution quality.
Morphing Airfoil Shape Change Optimization With Minimum Actuator Energy As An Objective (2002)

Morphing aircraft are multi-role aircraft that use innovative actuators, effectors, and mechanisms to change their state to perform select missions with substantially improved system performance. State change in this study means a change in the cross-sectional shape of the wing itself, not chord extension or span extension. Integrating actuators and mechanisms into an effective, light weight structural topology that generates lift and sustains the air loads generated by the wing is central to the success of morphing, shape changing wings and airfoils. The objective of this study is to explore a process to link analytical models and optimization tools with design methods to create energy efficient, lightweight wing/structure/actuator combinations for morphing aircraft wings. In this case, the energy required to change from one wing or airfoil shape to another is used as the performance index for optimization while the aerodynamic performance such as lift or drag is constrained. Three different, but related, topics are considered: energy required to operate articulated trailing edge flaps and slats attached to flexible 2D airfoils; optimal, minimum energy, articulated control deflections on wings to generate lift; and, deformable airfoils with cross-sectional shape changes requiring strain energy changes to move from one lift coefficient to another. Results indicate that a formal optimization scheme using minimum actuator energy as an objective and internal structural topology features as design variables can identify the best actuators and their most effective locations so that minimal energy is required to operate a morphing wing. Background
Tumor-Derived Cytokines Dysregulate Macrophage Interferon-γ Responsiveness and Interferon Regulatory Factor-8 Expression (2003)

Tumors can evade immune responses through suppressor signals that dysregulate host effector cell function. In this study we demonstrate that tumor-derived suppressor molecules impede host antitumor immune activity through dysregulation of multiple macrophage (Mphi) pathways, including suppressed production of cytotoxic and immunostimulatory agents and impaired expression of the interferon regulatory factor-8 (IRF-8) protein, a critical transducer of interferon-gamma-mediated activation pathways. The tumor-derived immunosuppressive cytokines interleukin-10 and transforming growth factor-beta(1) constrain IRF-8 production by normal Mphis, regardless of priming, and IRF-8 is also dysregulated in primary Mphis from tumor-burdened hosts. Collectively, these data describe a new mechanism by which tumors disrupt immune function and suggest that abrogation of tumor-derived immunoregulatory factors in situ can restore immune function and enhance antitumor efficacy.
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function (2004)

Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor penetration. We carried out structure-activity relationship (SAR) studies with the Tenascin-C binding aptamer TTA1, which is a promising candidate for application in tumor imaging with radioisotopes. The aim was to improve its in vivo stability and target binding. We investigated the effect of thermal stabilization of the presumed non-binding double-stranded stem region on binding affinity and resistance against nucleolytic degradation. To achieve maximal thermal stem stabilization melting experiments with model hexanucleotide duplexes consisting of unmodified RNA, 2 0 -O-methyl RNA (2 0 -OMe), 2 0 -Fluoro RNA (2 0 -F) or Locked Nucleic Acids (LNAs) were initially carried out. Extremely high melting temperatures have been found for an LNA/LNA duplex. TTA1 derivatives with LNA and 2 0 -OMe modifications within the nonbinding stem have subsequently been synthesized. Especially, the LNA-modified TTA1 derivative exhibited significant stem stabilization and markedly improved plasma stability while maintaining its binding affinity to the target. In addition, higher tumor uptake and longer blood retention was found in tumor-bearing nude mice. Thus, our strategy to introduce LNA modifications after the selection procedure is likely to be generally applicable to improve the in vivo stability of aptamers without compromising their binding properties.
Quantum well electron transfer waveguide with high coupling efficiency to single-mode fiber (1995)

We demonstrate low fiber-waveguide coupling loss in a large optical mode barrier reservoir and quantum well electron transfer (BRAQWET) modulator. Electrooptic efficiency and propagation loss are comparable to those measured in a conventional waveguide structure with the same active material.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Almost Prüferv-Multiplication Domains and Related Domains of the FormD + DS[Γ*] (2013)

Let D be an integral domain, S be a (saturated) multiplicative subset of D such that D ⊊ D S , Γ be a numerical semigroup with Γ ⊊ ℕ0, Γ* = Γ∖{0}, X be an indeterminate over D, D + XD S [X] = {a + Xg ∈ D S [X]∣a ∈ D and g ∈ D S [X]}, and D + D S [Γ*] = {a + f ∈ D S [Γ]∣a ∈ D and f ∈ D S [Γ*]}; so D + D S [Γ*] ⊊ D + XD S [X]. In this article, we study when D + D S [Γ*] is an APvMD, an AGCD-domain, an AS-domain, an AP-domain, or an AB-domain.
A clustering scheme for resource allocation of OFDMA based cellular systems (2014)

This paper presents a cluster based resource allocation scheme for allocating physical resource blocks (PRBs) in downlink of OFDMA based cellular systems. The proposed scheme includes two phases of clustering and sum rate maximization. In the first phase users are clustered by using an interference graph in a way that users in each cluster are allocated the same PRB. This interference graph helps users to avoid severe interference caused by neighbor cell base stations (BSs), since users that receive high interference from each other's serving BSs are not in the same cluster. In the second phase, the sum weighted rate of users in each cluster is calculated for all PRBs. These values shape the rate matrix. Then, by applying Hungarian algorithm to rate matrix, the optimal resource allocation that maximizes the sum rate of clusters is obtained. Furthermore, users are grouped into cell center users and cell edge ones according to their distance from the BSs. The transmission power levels of users are fixed in two levels, in which the higher level is for cell edge users. Simulation results show that our proposed scheme improves both the throughput of cell edge users and cell center users, compared with the other schemes.
Laser based measurement of refractive index changes: Kinetics of 2,3-epoxy-1-propanol hydrolysis (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser based measurement of refractive index changes: Kinetics of 2,3-epoxy-1-propanol hydrolysisBert Spencer and Richard N. Zare Cite this: J. Chem. Educ. 1988, 65, 9, 835Publication Date (Print):September 1, 1988Publication History Received3 August 2009Published online1 September 1988Published inissue 1 September 1988https://doi.org/10.1021/ed065p835Request reuse permissionsArticle Views269Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Identification of Cys-150 in the active site of phosphomannose isomerase from Candida albicans (1993)

Candida albicans phosphomannose isomerase (PMI) (EC 5.3.1.8) has been recently cloned and overexpressed in Escherichia coli. The enzyme can be irreversibly inactivated by iodoacetate in 50 mM borate buffer, pH 9.0, in a time-dependent manner at a rate of 4.2 +/- 0.03 min-1 M-1. This inhibition can be prevented by the substrate mannose 6-phosphate with a Ks of 0.22 +/- 0.05 mM, slightly lower than its Km value. However, metals such as zinc and cadmium, which are reversible, competitive inhibitors for PMI, do not protect the enzyme against modification. The protein has been labeled by using [2-14C]iodoacetate, in the presence or absence of substrate, and the protein is fully inactivated when 1.0 thiol group is modified per molecule of enzyme. Tryptic maps of the modified protein have been produced. The protected peptide has been identified and sequenced, and the phenylthiohydantoin amino acids have been collected. The modified amino acid is Cys-150. This cysteine residue is conserved in mammalian and yeast phosphomannose isomerases, but not in bacterial species where it is replaced with asparagine. We therefore purified PMI from E. coli and showed that this enzyme is not sensitive to inactivation by iodoacetate. The iodoacetate is presumably inhibiting PMI by sterically blocking the mannose 6-phosphate binding site. Multiple sequence alignment procedures were used to try to identify potential ligands of the zinc atom that is essential for enzyme activity and thus to delineate the active site region.(ABSTRACT TRUNCATED AT 250 WORDS)
Population growth of Varroa destructor (Acari: Varroidae) in commercial honey bee colonies treated with beta plant acids (2014)

Varroa (Varroa destuctor Anderson and Trueman) populations in honey bee (Apis mellifera L.) colonies might be kept at low levels by well-timed miticide applications. HopGuard(®) (HG) that contains beta plant acids as the active ingredient was used to reduce mite populations. Schedules for applications of the miticide that could maintain low mite levels were tested in hives started from either package bees or splits of larger colonies. The schedules were developed based on defined parameters for efficacy of the miticide and predictions of varroa population growth generated from a mathematical model of honey bee colony-varroa population dynamics. Colonies started from package bees and treated with HG in the package only or with subsequent HG treatments in the summer had 1.2-2.1 mites per 100 bees in August. Untreated controls averaged significantly more mites than treated colonies (3.3 mites per 100 bees). By October, mite populations ranged from 6.3 to 15.0 mites per 100 bees with the lowest mite numbers in colonies treated with HG in August. HG applications in colonies started from splits in April reduced mite populations to 0.12 mites per 100 bees. In September, the treated colonies had significantly fewer mites than the untreated controls. Subsequent HG applications in September that lasted for 3 weeks reduced mite populations to levels in November that were significantly lower than in colonies that were untreated or had an HG treatment that lasted for 1 week. The model accurately predicted colony population growth and varroa levels until the fall when varroa populations measured in colonies established from package bees or splits were much greater than predicted. Possible explanations for the differences between actual and predicted mite populations are discussed.
Development of a quantitative method to predict critical shear stress and rate of erosion of natural undisturbed cohesive soils (1980)

A study was conducted in an attempt to develop a quantitative method to predict the hydraulic shear stress at which erosion is initiated (critical shear stress) and the rate of erosion of natural soil (with sufficient cohesiveness to allow undisturbed samples to be taken) along a stream bank. In order to obtain a wide range of properties with sufficient geographical distribution, soil and river water samples were requested from Corps of Engineers (CE) Districts in the United States. Preliminary tests conducted on 42 samples included: (a) free swell test on undisturbed soil; (b) dielectric dispersion on remolded soil; (c) slaking test on undisturbed soil; (d) amount of clay present in soil; (e) soil chemistry (pH and soluble cations); and (g) river water chemistry (pH and soluble cations). Based upon the results of preliminary tests 30 soils were selected for detailed analysis which included: (a) index property tests (hydrometer analyses, specific gravity, organic content, gypsum content, moisture content, unit weight, and Atterberg limits); (b) soil chemistry (exchangeable cations); (c) dielectric dispersion on undisturbed soil; (d) flume erosion tests on undisturbed soil; and (e) rotating cylinder erosion tests on saturated remolded soil.
ChemInform Abstract: NEW STEREOSPECIFIC SYNTHESIS OF CIS AND TRANS D,L‐CHRYSANTHEMIC ESTERS AND ANALOGS VIA A COMMON INTERMEDIATE (1978)

Abstract Maleinsäure‐ und Fumarsäureester (I) kondensieren nach Wittig mit (II) zu den Cyclopropanen (III) die zu (IV) verseift und dann zu den Carbinolen (V) reduziert werden.
Automatic morphometry of synaptic boutons of cultured cells using granulometric analysis of digital images (2005)

Numbers, linear density, and surface area of synaptic boutons can be important parameters in studies on synaptic plasticity in cultured neurons. We present a method for automatic identification and morphometry of boutons based on filtering of digital images using granulometric analysis. Cultures of cortical neurons (DIV8 and DIV21) were fixed and marked with fluorescently labeled antibodies for synapsin I (a marker for synaptic boutons) and MAP-2 (a marker for dendrites). Images were acquired on a confocal microscope and automatically processed. Granulometry, a morphological operator sensitive to the geometry and size of objects, was used to construct a filter passing fuzzy fluorescent grains of a certain size. Next, the filter was overlaid with the original image (masking) and the positive pixels were identified by an integral intensity threshold (thresholding). Disjoint grains, representing individual boutons, were reconstructed from the connected pixels above the threshold, numbered and their area was measured. In total, 1498 boutons with a mean diameter of 1.63 +/- 0.49 microm (S.D.) were measured. Comparisons with manual counts showed that the proposed method was capable of identifying boutons in a systematic manner at the light microscopic level and was a viable alternative to manual bouton counting.
Inactivation of penaeid rod-shaped DNA virus(PRDV), the causative agent of penaid acute viremia(PAV), by some chemical and physical treatments. (1998)

PRDVの化学的・物理的不活化条件をバイオアッセイ法によって調べた。 その結果, 化学的処理では有効塩素濃度1mg/l10分間, 有効ヨウ素濃度2.5 mg/l 10分間, 残留オキシダント0.62mg/l 1分間, エタノール30%1分間, ホルマリン5 g/l 10分間, 塩化トリメチルアンモニウムメチレン25mg/l 10分間, 炭酸ナトリウム過酸化水素付加物5,000 mg/l 60分間, 食塩25%24時間, クロロフォルム処理でそれぞれ不活化された。 また, 物理的処理では加熱50℃ 60分間, 60℃ 1分間, 70℃ 0.2分間で, 乾燥3時間で, 紫外線照射量1×104 μW・sec/cm2でそれぞれ不活化された。