gebhart/patrepeval huggingface dataset:
Performance of an IAVI-African Network of Clinical Research Laboratories in Standardized ELISpot and Peripheral Blood Mononuclear Cell Processing in Support of HIV Vaccine Clinical Trials (2018)

Abstract Immunological assays performed in different laboratories participating in multi-centre clinical trials must be standardized in order to generate comparable and reliable data. This entails standardized procedures for sample collection, processing, freezing and storage. The International AIDS Vaccine Initiative (IAVI) partnered with local institutions to establish Good Clinical Laboratory Practice (GCLP)-accredited laboratories to support clinical trials in Africa, Europe and Asia. Here we report on the performance of seven laboratories based in Africa and Europe in the interferon-gamma enzyme-linked immunospot (IFN-γ ELISpot) assay and peripheral blood mononuclear cell (PBMC) processing over four years. Characterized frozen PBMC samples from 48 volunteer blood packs processed at a central laboratory were sent to participating laboratories. For each stimulus, there were 1751 assays performed over four years. 98% of these ELISpot data were within acceptable ranges with low responses to mock stimuli. There were no significant differences in ELISpot responses at five laboratories actively conducting immunological analyses in support of IAVI sponsored clinical trials or HIV research. In a separate study, 1,297 PBMC samples isolated from healthy HIV-1 negative participants in clinical trials of two prophylactic HIV vaccine candidates were analysed for PBMC yield from fresh blood and cell recovery and viability following freezing and thawing. 94 % and 96 % of samples had fresh PBMC viabilities and cell yields within the pre-defined acceptance criteria while for frozen PBMC, 99 % and 96 % of samples had acceptable viabilities and cell recoveries respectively, along with acceptable ELISpot responses in 95%. These findings demonstrate the competency of laboratories across different continents to generate comparable and reliable data in support of clinical trials. Importance There is a need for the establishment of an African network of laboratories to support large clinical trials across the continent to support and further the development of vaccine candidates against emerging infectious diseases such as Ebola, Zika and dengue viruses and the continued HIV-1 pandemic. This is particularly true in sub-Saharan Africa where the HIV-1 pandemic is most severe. In this report we have demonstrated by using standardized SOPs, training, equipment and reagents that GCLP-accredited clinical trial laboratories based in Africa and Europe can process clinical trial samples and maintain cell integrity and functionality demonstrated by IFN-γ ELISpot testing, producing comparable and reliable data.
Voltage Regulation Algorithms for Multiphase Power Distribution Grids (2015)

Time-varying renewable energy generation can result in serious under-/over-voltage conditions in future distribution grids. Augmenting conventional utility-owned voltage regulating equipment with the reactive power capabilities of distributed generation units is a viable solution. Local control options attaining global voltage regulation optimality at fast convergence rates is the goal here. In this context, novel reactive power control rules are analyzed under a unifying linearized grid model. For single-phase grids, our proximal gradient scheme has computational complexity comparable to that of the rule suggested by the IEEE 1547.8 standard, but it enjoys well-characterized convergence guarantees. Furthermore, adding memory to the scheme results in accelerated convergence. For three-phase grids, it is shown that reactive power injections have a counter-intuitive effect on bus voltage magnitudes across phases. Nevertheless, when our control scheme is applied to unbalanced conditions, it is shown to reach an equilibrium point. Numerical tests using the IEEE 13-bus, the IEEE 123-bus, and a Southern California Edison 47-bus feeder with increased renewable penetration verify the properties of the schemes and their resiliency to grid topology reconfigurations.
Effects of Polyethyleneimine-Mediated Functionalization of Multi-Walled Carbon Nanotubes on Earthworm Bioaccumulation and Sorption by Soils (2011)

Carbon nanotubes (CNTs) are often modified for different intended potential applications to enhance their aqueous stability or change properties such as surface charge. Such changes may also profoundly impact their environmental behaviors. Herein, we report the effects of modifying (14)C-labeled multiwalled carbon nanotubes (MWCNTs) with polyetheyleneimine (PEI) surface coatings to render them more stable in solution and to give them positive, negative, or neutral surface charges. These carbon nanotubes were used to test their sorption by soils and uptake and elimination behaviors by earthworms. Sorption results indicate nearly linear sorption isotherms for regular MWCNTs and nonlinear isotherms for modified MWCNTs, indicating that the PEI coatings influenced MWCNT interactions with soils. Nevertheless, there were minimal differences in the sorption results among the different soils for each type of nanotube despite differences in the soil organic carbon and cation exchange capacities. Differences in uptake behaviors by earthworms were not apparent among different types of PEI-MWCNTs and MWCNTs with limited absorption into organism tissues consistently observed. Elimination patterns were well fit with an exponential decay model suggesting that the worms can readily eliminate any accumulated MWCNTs.
HomeBank: An Online Repository of Daylong Child-Centered Audio Recordings (2016)

HomeBank is introduced here. It is a public, permanent, extensible, online database of daylong audio recorded in naturalistic environments. HomeBank serves two primary purposes. First, it is a repository for raw audio and associated files: one database requires special permissions, and another redacted database allows unrestricted public access. Associated files include metadata such as participant demographics and clinical diagnostics, automated annotations, and human-generated transcriptions and annotations. Many recordings use the child-perspective LENA recorders (LENA Research Foundation, Boulder, Colorado, United States), but various recordings and metadata can be accommodated. The HomeBank database can have both vetted and unvetted recordings, with different levels of accessibility. Additionally, HomeBank is an open repository for processing and analysis tools for HomeBank or similar data sets. HomeBank is flexible for users and contributors, making primary data available to researchers, especially those in child development, linguistics, and audio engineering. HomeBank facilitates researchers' access to large-scale data and tools, linking the acoustic, auditory, and linguistic characteristics of children's environments with a variety of variables including socioeconomic status, family characteristics, language trajectories, and disorders. Automated processing applied to daylong home audio recordings is now becoming widely used in early intervention initiatives, helping parents to provide richer speech input to at-risk children.
Variables in chemi-thermomechanical pulping of northern hardwoods (1987)

Dans un processus CTMP en deux etapes, on etudie les effets de la charge en alcali dans la premiere etape et du sulfite dans la deuxieme etape sur l'energie de raffinage et sur les proprietes optiques et physiques de la pâte
Generalized van der Waals theories for surface tension and interfacial width (1973)

An exact relation between surface tension and the direct correlation function (DCF) for the inhomogeneous region is developed which may be viewed as an exact formulation of the van der Waals density gradient theory for inhomogeneous fluids. A reasonable approximation to the DCF is employed to obtain characteristic features of the interfacial density gradient over an extended temperature range. This theory predicts that the interfacial width increases as (1−T/Tc)−0.65 at the ``low'' temperatures considered, and these results are in good agreement with the corresponding predictions of our earlier capillary wave treatment of interfaces. Comparison is also made with the predictions of an alternate, exact van der Waals-like formulation which is obtained from the expression for surface tension in terms of the pair number density and the intermolecular force. A combination of the DCF formulation and the capillary wave theory provides the possibility of predicting both interfacial thicknesses and surface tension, a route also available from pair capillary wave theory. Numerical examples corresponding to argon at 90°K are given.
Éditorial (2015)

lectronique Cairn.info pour Association des amis de l'cole de Paris. La reproduction ou reprsentation de cet article, notamment par photocopie, n'est autorise que dans les limites des conditions gnrales d'utilisation du site ou, le cas chant, des conditions gnrales de la licence souscrite par votre tablissement. Toute autre reproduction ou reprsentation, en tout ou partie, sous quelque forme et de quelque manire que ce soit, est interdite sauf accord pralable et crit de l'diteur, en dehors des cas prvus par la lgislation en vigueur en France. Il est prcis que son stockage dans une base de donnes est galement interdit.
Asymmetric Synthesis of (αR)-Polyfluoroalkylated Prolinols Based on the Perfluoroalkyl-Induced Highly Stereoselective Reduction of Perfluoroalkyl N-Boc-pyrrolidyl Ketones (2008)

Reduction of the obtained chiral (S)- tert-butyl 2-(perfluoroalkanoyl)pyrrolidine-1-carboxylate with sodium borohydride or lithium aluminum hydride proceeded smoothly to give the corresponding (S)- tert-butyl 2-((R)-perfluoro-1-hydroxyalkyl)pyrrolidine-1-carboxylate in yields of 73-97% with excellent diastereoselectivities (up to >98% de), compared with the reduction of nonfluorinated (S)-tert-butyl 2-pentanoylpyrrolidine-1-carboxylate.
Upper temperature limit and multi-channel effects in ellipsoidal lithium-niobate optical parametric oscillators (2018)

This paper theoretically investigated type-I optical parametric oscillations (OPOs) in lithium niobate (LN) ellipsoidal microcavities. We calculated the dependence of signal (idler) wavelength on temperature and found that multiple OPO channels are universal phenomenon in LN whispering gallery mode (WGM) microcavities. Additionally, We discovered OPOs in LN WGM microcavities, instead of having a lower-temperature limit, have an upper-temperature limit beyond which no OPO takes place. The dependence of the OPO tuning behaviors on the cavity geometry and pump wavelength was discussed systematically. Our investigations provide new conceptions for OPOs in LN WGM microcavities and may benefit the research on tunable laser sources or high-order entangled photon sources.
Some Chlorinated 4-Indanols: Preparation and Proof of Structures1 (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Chlorinated 4-Indanols: Preparation and Proof of Structures1J. S. Buck, R. A. Cutler, F. C. Nachod, R. G. Powles, R. Rakoczy, T. J. Slauson, and B. F. TullarCite this: J. Am. Chem. Soc. 1957, 79, 13, 3559–3561Publication Date (Print):July 1, 1957Publication History Published online1 May 2002Published inissue 1 July 1957https://pubs.acs.org/doi/10.1021/ja01570a068https://doi.org/10.1021/ja01570a068research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: New Diterpenes from a New Species of Lobophytum Soft Coral of the South Andaman Coast. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel Composite Sorbent Beads for Paraquat Removal by Hemoperfusion (1983)

The present report describes the development and performance of a column that is to be used for removal of paraquat from circulating blood in a hemoperfusion-type set-up. The key element of the system is a newly developed sorbent material containing fuller's earth entrapped in cross-linked agarose beads (Talosit). The technique produces a sorbent material exhibiting a very large active surface area while allowing for high mobility of paraquat molecules within the beads and favorable flow characteristics of packed column. Cross-linking of the agarose (by epichlorohydrin) also has a most beneficial effect on the mechanical strength of the beads as well as on their stability to sterilization in an autoclave. The composite beads exhibit good blood compatibility. A scanning electron microscope analysis of the beads showed no adherence of cellular blood components after contact with blood. Moreover, no significant changes in plasma composition had taken place when the beads were properly conditioned prior to contact with fresh human blood. A comparative study of paraquat removal from saline solution by the new beads and by cellulose-coated activated charcoal (Adsorba-300C) indicates a higher removal rate with the former. The results obtained so far with this new sorbent are very promising and extension of these studies to in vivo hemoperfusion is under way.
Flawed interferon response spurs severe illness (2020)

Antibodies or mutations that cripple key antivirus protein underlie 14% of severe cases.
From Classical to Advanced Use of Polymers in Food and Beverage Applications (2022)

Polymers are extensively used in food and beverage packaging to shield against contaminants and external damage due to their barrier properties, protecting the goods inside and reducing waste. However, current trends in polymers for food, water, and beverage applications are moving forward into the design and preparation of advanced polymers, which can act as active packaging, bearing active ingredients in their formulation, or controlling the head-space composition to extend the shelf-life of the goods inside. In addition, polymers can serve as sensory polymers to detect and indicate the presence of target species, including contaminants of food quality indicators, or even to remove or separate target species for later quantification. Polymers are nowadays essential materials for both food safety and the extension of food shelf-life, which are key goals of the food industry, and the irruption of smart materials is opening new opportunities for going even further in these goals. This review describes the state of the art following the last 10 years of research within the field of food and beverage polymer's applications, covering present applications, perspectives, and concerns related to waste generation and the circular economy.
Externally controlled drug release using a gold nanorod contained composite membrane (2016)

Versatile drug delivery devices using nanoporous membranes consisting of gold nanorods and dendrimers have been demonstrated to provide light-triggered on-demand pulsatile release from a reservoir containing highly enriched therapeutics for a real patient's needs. The drug release rate is directly correlated with the temperature increase and irradiated energy of a near-IR laser in both static and fluidic devices. This biocompatible platform for on-demand control was further confirmed by in vitro experiments. Interestingly, different responses to stimuli were obtained from each drug in the absence and presence of NIR light, indicating the versatile potential of our on-demand drug delivery system in less-invasive therapies requiring multi-drug delivery strategies. The enhanced delivery system will improve therapeutic efficacy and reduce side effects through regulation of plasma drug profiles.
Obinutuzumab For The Treatment Of Indolent Lymphoma (2016)

Obinutuzumab is a humanized, type II anti-CD20 monoclonal antibody designed for strong induction of direct cell death and antibody-dependent cell-mediated cytotoxicity. The Phase III GADOLIN trial tested the clinical efficacy of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy in rituximab-refractory indolent non-Hodgkin lymphoma versus treatment with bendamustine alone. It demonstrated significantly longer progression-free survival for the obinutuzumab-containing regimen in this difficult to treat patient group. Based on the results of this trial, US FDA approval was most recently granted for obinutuzumab in the treatment of follicular lymphoma that has relapsed after or was refractory to a rituximab-containing regimen. This article summarizes the available data on chemistry, pharmacokinetics, clinical efficacy and safety of obinutuzumab in the treatment of indolent non-Hodgkin lymphoma.
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells (2021)

A single protein can be multifaceted depending on the cellular contexts and interacting molecules. LIN28A is an RNA-binding protein that governs developmental timing, cellular proliferation, differentiation, stem cell pluripotency, and metabolism. In addition to its best-known roles in microRNA biogenesis, diverse molecular roles have been recognized. In the nervous system, LIN28A is known to play critical roles in proliferation and differentiation of neural progenitor cells (NPCs). We profiled the endogenous LIN28A-interacting proteins in NPCs differentiated from human induced pluripotent stem (iPS) cells using immunoprecipitation and liquid chromatography-tandem mass spectrometry. We identified over 500 LIN28A-interacting proteins, including 156 RNA-independent interactors. Functions of these proteins span a wide range of gene regulatory processes. Prompted by the interactome data, we revealed that LIN28A may impact the subcellular distribution of its interactors and stress granule formation upon oxidative stress. Overall, our analysis opens multiple avenues for elaborating molecular roles and characteristics of LIN28A.
Delayed HIV treatment, barriers in access to care and mortality in tuberculosis/HIV co-infected patients in Cali, Colombia (2021)

Objective: To determine factors associated with mortality in tuberculosis/HIV co-infected patients in Cali, Colombia Methods: This retrospective cohort design included tuberculosis/HIV co-infected persons. Kaplan-Meier and Cox regression were used to estimate survival and risk factors associated with mortality. Results: Of the 279 tuberculosis/HIV co-infected participants, 27.2% died during the study. Participants mainly were adults and males. CD4 count information was available for 41.6% (the median count was 83 cells/mm3), and half were subject to tuberculosis susceptibility testing. The median time between HIV diagnosis and antiretroviral therapy initiation was 372 days. HIV was identified prior to tuberculosis in 53% and concurrent HIV-tuberculosis were diagnosed in 37% of patients. 44.8% had tuberculosis treatment success. Body mass index above 18 kg/m2, initiation of tuberculosis treatment within two weeks, having any health insurance coverage and CD4 count information conferred a survival advantage. Conclusions: Delays in treatment initiation and factors associated with limited health care access or utilization were associated with mortality. As HIV and tuberculosis are both reportable conditions in Colombia, strategies should be focused on optimizing treatment outcomes within both tuberculosis and HIV programs, particularly improving early HIV diagnosis, early antiretroviral therapy treatment initiation, and adherence to tuberculosis treatment.
Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice (1996)

Mice bearing the autosomal recessive mutation 'wasted' (wst/wst) express a disease syndrome characterized by neurologic dysfunction, immunodeficiency, and increased sensitivity to the killing effects of ionizing radiation relative to normal littermates (wst/-) and to parental control mice (BCF1, BALB/c, and C57BL/6). Many of these abnormalities, evident as early as 21 days of age, have been localized to thymic tissues and T-lymphocyte populations. Comparison of two-dimensional gel electrophoresis patterns of proteins from wst/wst and control mouse thymus revealed that an acidic protein with a molecular mass of approximately 30 kDa was consistently expressed at lower levels in wasted mice than in controls. Microsequencing of this protein revealed a sequence of 19 N-terminal amino acids identical to the sequence of murine proliferating cell nuclear antigen (PCNA). Northern blot analyses of PCNA expression in thymus and spleen demonstrated lower accumulation of PCNA-specific transcripts in wasted mice compared with that in controls. Because PCNA expression is associated with cell cycle progression, the percentages of thymic and splenic cells in each stage of the cell cycle were examined; there were no differences in the cell stage distribution of lymphocytes freshly isolated from wasted mice compared with littermate or parental controls. After activation with concanavalin A, however, splenocytes from wst/wst mice showed a lower percentage of cells in S phase compared with that in controls. Southern blots with PCNA probes showed that the PCNA loci from the wasted mice and their normal littermates have the same restriction maps. While differences in polymerase chain reaction (PCR) priming were obtained, these could be attributed to strain-specific differences in mouse PCNA pseudogenes. These results suggest the presence of an alteration in the pathway leading to PCNA expression in radiation-sensitive tissues of wasted mice.