gebhart/patrepeval huggingface dataset:
Client-server, distributed database strategies in a healthcare record system for a homeless population. (1993)

A computer-based healthcare record system being developed for Boston's Healthcare for the Homeless Program (BHCHP) uses client-server and distributed database technologies to enhance the delivery of healthcare to patients of this unusual population. The needs of physicians, nurses and social workers are specifically addressed in the application interface so that an integrated approach to healthcare for this population can be facilitated. These patients and their providers have unique medical information needs that are supported by both database and applications technology. To integrate the information capabilities with the actual practice of providers of care to the homeless, this computer-based record system is designed for remote and portable use over regular phone lines. An initial standalone system is being used at one major BHCHP site of care. This project describes methods for creating a secure, accessible, and scalable computer-based medical record using client-server, distributed database design.
Simultaneous Localization And Mapping Using a Kinect in a Sparse Feature Indoor Environment (2012)

Localization and mapping are two of the most central tasks when it comes toautonomous robots. It has often been performed using expensive, accurate sensorsbut the fast development of consumer electronics has made similar sensorsavailable at a more affordable price. In this master thesis a TurtleBot\\texttrademark\\, robot and a MicrosoftKinect\\texttrademark\\, camera are used to perform Simultaneous Localization AndMapping, SLAM. The thesis presents modifications to an already existing opensource SLAM algorithm. The original algorithm, based on visual odometry, isextended so that it can also make use of measurements from wheel odometry and asingle axis gyro. Measurements are fused using an Extended Kalman Filter,EKF, operating in a multirate fashion. Both the SLAM algorithm and the EKF areimplemented in C++ using the framework Robot Operating System, ROS. The implementation is evaluated on two different data sets. One set isrecorded in an ordinary office room which constitutes an environment with manylandmarks. The other set is recorded in a conference room where one of the wallsis flat and white. This gives a partially sparse featured environment. The result by providing additional sensor information is a more robust algorithm.Periods without credible visual information does not make the algorithm lose itstrack and the algorithm can thus be used in a larger variety of environmentsincluding such where the possibility to extract landmarks is low. The resultalso shows that the visual odometry can cancel out drift introduced bywheel odometry and gyro sensors.
SOLID/GAS BIOREACTORS: POWERFUL TOOLS FOR FUNDAMENTAL RESEARCH AND EFFICIENT TECHNOLOGY FOR INDUSTRIAL APPLICATIONS. (2004)

International audience
A domain decomposition method for solving 3-D complex structures (2011)

Linear embedding via Green's operators (LEGO) is a domain decomposition method for solving electromagnetic problems which involve composite 3-D structures. By combining the standard Method of Moments with a set of macro basis functions obtained through the Arnoldi iteration, the algebraic system of LEGO can be effectively compressed. However, under general circumstances it is not easy to choose the minimum number of macro basis functions for a given level of accuracy, since many physical and geometrical factors come into play. To shed light on this topic, we discuss a few examples with a focus on the convergence of the numerical solution.
Impact of Biosimilar Insulins on Clinical Practice (2014)

The availability of biosimilar insulins can potentially lead to lower insulin costs and increased access for patients with diabetes, worldwide. However, clinicians and regulatory agencies have raised several concerns regarding the safety and efficacy of these new medications. The European regulatory agencies have established guidelines for market approval of biosimilar insulins; however, many issues remain unresolved. Moreover, although the FDA has developed preliminary pathways for biosimilar protein development and is prepared to review each application on a case-by-case basis, insulins do not fall under this pathway at this time. The development of effective postmarketing surveillance protocols, determination of product interchangeability, and product identification/labeling remain key concerns. Numerous issues surround the development and commercialization of biosimilar insulins; thus, it is important that all stakeholders fully understand the complexity of these issues and how they can potentially affect patient care. Bridging the educational gap among clinicians and regulatory agencies will be challenging but necessary for ensuring patient safety.
Figure A2 from Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial (2023)

Figure A2 from Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial
ChemInform Abstract: SYNTHESIS OF SUBSTITUTED BARBARALANES BY ELECTROCHEMICAL REDUCTION OF BRIDGED 1,5‐BENZODIAZEPINES (1980)

Abstract Die aus den o‐Phenylendiaminen (I) und dem Diketon (II) zugänglichen verbrückten Benzodiazepine (III) werden elektrochemisch bei normaler Aufarbeitung zu den Barbaralanen (IV) reduziert.
Bridging Bench to Bedside in Fetal and Neonatal Brain Injury (2007)

The immature brain is vulnerable to prenatal and postnatal stresses, which may produce brain damage leading to neurological dysfunction in survivors. This special issue presents new in-sights into the detection, pathophysiology and treatment of developmental brain injuries. Importantly, several papers in this issue report pre-clinical tests of new
Domestic Retrofit Assessment of the Heat Pump System Considering the Impact of Heat Supply Temperature and Operating Mode of Control—A Case Study (2021)

In this study, performance assessment of the variable speed compressor-based air source heat pump (ASHP) system as a domestic retrofit technology instead of fossil fuel-based heating technologies for the 1900s Mid terraced house is investigated. The assessment was conducted considering operating mode of control and heat supply temperature impact of the system. In the literature, ASHP system experimental development with variable speed mode (VSM) of control in comparison to fixed speed mode (FSM) of control at low to medium and high heat supply temperature in the context of UK was found with very limited number of studies, but without considering retrofit application. The focus of the earlier studies was on the individual components and performance improvement. The designed heat pump (HP), developed, and tested at constant heat load, simulating the real domestic heat demand under the controlled laboratory conditions and numerical modeling is utilized for the analysis purposes. The HP performance, energy demand, carbon emissions, and cost varies significantly due to changing heat supply temperature (35 °C, 45 °C, and 55 °C), control mode and accordingly the carbon emission and cost savings are achieved. The oil and gas boilers ranges from conventional to highly efficient type and evaluated in terms of annual running cost, energy consumptions, and carbon emissions in comparison with the HP system. Additionally, a comparative study with the existing retrofitted very high temperature ASHP inside the house is conducted. The developed HP at 55 °C could not defeat the very high heat supply temperature HP system (75 °C supply temperature) in performance and cost savings but become attractive at low supply temperature (35 °C). The HP system in VSM at low heat supply temperature instead of gas boiler (90% efficiency) could cut the annual carbon emissions by 59% but with additional 6% running cost for the Mid terraced test house in Belfast climatic conditions.
Secretory Leukemic B Cells Express T Cell Markers In Vitro A Phenomenon Suppressed by TPA (1986)

Immunological and biochemical markers of leukemia/lymphoma cells have provided valuable insight into hematopoietic malignancy and normal differentiation. The general assumption is that as early lymphoid cells become committed towards terminal differentiation they lose their capacity for bimodal differentiation and cells become restricted to B or T cell development and function. We have observed that phenotypically "late" leukemic B cells close to secretory stage can spontaneously express mature T cell antigens (T11, T4 and T8) after culture in vitro. In further studies of these cells, it was found that the biochemical marker lactate Dehydrogenase (LD) follows the intermediate pattern expressed by thymocytes rather than that of typical B cells. The expression of T cell antigens can be blocked by incubating these cells with the phorbol ester TPA (12-0-tetradecanoyl phorbol 13 acetate) which promotes unidirectional B cell maturation to plasmacytoid cells in a way that mimics normal B cell differentiation. These observations indicate that presecretory malignant B cells are still programmed to express T cell biochemical and antigenic markers and this expression can be influenced by environmental conditions in vitro.
Effects of Firing Temperature and Film Thickness on the Critical Properties of YBCO Film by the '211 Process' (2007)

We fabricated by metal organic deposition (MOD) using trifluoroacetic acid (TFA) via the “211 process”, and then evaluated the phase formation, texture evolution, and critical properties as a function of the firing temperature and film thickness. In the fabrication process, Y2Ba1Cu1Ox and Ba3Cu5O8 powders were used as precursors instead of Y-, Ba- and Cu-based acetates. The films were fired in the temperature range of 750°C -800°C and the film thickness of films was controlled by repeating the number of coating cycles. The microstructure varied significantly with the firing temperature. The grains size increased, the film became denser, and the degree of the texture and phase purity varied with increasing firing temperature. The films fired at 775°C after calcining at 4005 showed the highest critical current (Ic) of 18 A/cm-width, which corresponds to a critical current density (Jc) of 0.9 MA/cm2. For multi-coated films, the Ic increased from 18 in the singly coated film to 100 A/cm-width with the triply coated film. In contrast, the corresponding Jc were in the range of 0.9-1.2 MA/cm2. Both Ic and Jc values decreased as the coating number repeated further as a result of the degraded microstructure.
Controlling the phase response of a diffusive wave phased array system (2000)

Previous phased array research using anti-phase sources has shown that the phase response to an object scanned through a heavily scattering medium provides information about object position but none about size. In this paper it is demonstrated that controlling the relative phase between the sources enables different phase gradients to be set within the medium. The consequence of this is that the phase response is dependent on the size of an object whilst still maintaining localization information. Furthermore, it is demonstrated that the phase response can be tuned to be most sensitive to the object size under investigation.
Lifestyle and Successful Aging: An Overview (2008)

Since the 1950s, the phrase successful aging has been used increasingly to represent the factors and conditions underlying healthy aging and is often attributed to the healthy elderly. In this short review, the authors discuss the transformation in the social theories of aging that allowed for the evolution of successful aging as a construct and ultimately a theoretical basis for investigation. Because of the multifactorial nature of the psychosocial and biomedical domains, there is no clear consensus on the definition of successful aging or its determinants. What is clear, however, is that successful aging is related to the human health span, or healthy life expectancy. Moreover, the accumulating information from multidimensional studies suggests that many age-associated changes in physiological and cognitive functioning can be explained by such modifiable lifestyle factors as smoking, physical activity, and nutrition choice. The evidence presented supports the promotion of a healthy lifestyle as an effective strategy for successful aging.
Electronic influences on 3J(C,H) coupling constants via S, S(O) and SO2: their determination, calculation and comparison of detection methods (2004)

3J(C,H) coupling constants via a sulfur atom in two series of compounds, both including a sulfide, a sulfoxide and a sulfone, were detected experimentally and calculated by quantum mechanical methods. In the first series (1-3) the coupling between a hydrogen, bonded to an sp3 carbon, and an sp2 carbon is treated; the second series (4-6) deals with the coupling between a hydrogen, bonded to an sp3 carbon, and an sp3 carbon. Different pulse sequences (broadband HMBC, SelJres, 1D HSQMBC, J-HMBC-2, selective J-resolved long-range experiment and IMPEACH-MBC) proved to be useful in determining the long-range 3J(C,H) coupling constants. However, the dynamic behaviour of two of the compounds (4 and 6) led to weighted averages of the two coupling constants expected (concerning equatorial and axial positions of the corresponding hydrogens). DFT calculations proved to be useful to calculate not only the 3J(C,H) coupling constants but also the different contributions of FC, PSO, DSO and SD terms; the calculation of the Fermi contact term (FC) was found to be sufficient for the correct estimation of 3J(C,H) coupling constants.
A business model for a Telecom 2.0 start-up (2009)

Started with some definitions of Telecom 2.0 and a brief discussion of business models, this paper then asked if there still are opportunities for start-ups in the Telecom 2.0 world. The authors proposed a user-centric approach for a telecom start-up. The business model is centred on multiple identity support, holistic Internet customer care, and safe online transactions. Since it is part of the poster session, the paper is written in such a way to ease the making of the poster.
Faculty Opinions recommendation of Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. (2013)

Patients with inflammatory bowel disease (IBD) have an increased risk of colon cancer. However, the immune cells and cytokines that mediate the transition from intestinal inflammation to cancer are poorly understood. We show that bacteria-induced colon cancer is accompanied by differential accumulation of IL-17(+)IL-22(+) colonic innate lymphoid cells (cILCs), which are phenotypically distinct from LTi and NK-22 cells, and that their depletion in mice with dysplastic inflammation blocks the development of invasive colon cancer. Analysis of the functional role of distinct Type 17 cytokines shows that although blockade of IL-17 inhibits some parameters of intestinal inflammation, reduction in dysplasia and colorectal cancer (CRC) requires neutralization of IL-22 indicating a unique role for IL-22 in the maintenance of cancer in this model. Mechanistic analyses showed that IL-22 selectively acts on epithelial cells to induce Stat3 phosphorylation and proliferation. Importantly, we could detect IL-22(+)CD3(+) and IL-22(+)CD3(−) cells in human CRC. Our results describe a new activity of IL-22 in the colon as a nonredundant mediator of the inflammatory cascade required for perpetuation of CRC, highlighting the IL-22 axis as a novel therapeutic target in colon cancer. PMID: 23589566 Funding information This work was supported by: Cancer Research UK, United Kingdom Grant ID: A7297 Cancer Research UK, United Kingdom Grant ID: A11663 Wellcome Trust, United Kingdom Grant ID: 095688
Neuromodulators, Not Activity, Control Coordinated Expression of Ionic Currents (2007)

Electrical activity in identical neurons across individuals is often remarkably similar and stable over long periods. However, the ionic currents that determine the electrical activity of these neurons show wide animal-to-animal amplitude variability. This seemingly random variability of individual current amplitudes may obscure mechanisms that globally reduce variability and that contribute to the generation of similar neuronal output. One such mechanism could be the coordinated regulation of ionic current expression. Studying identified neurons of the Cancer borealis pyloric network, we discovered that the removal of neuromodulatory input to this network (decentralization) was accompanied by the loss of the coordinated regulation of ionic current levels. Additionally, decentralization induced large changes in the levels of several ionic currents. The loss of coregulation and the changes in current levels were prevented by continuous exogenous application of proctolin, an endogenous neuromodulatory peptide, to the pyloric network. This peptide does not exert fast regulatory actions on any of the currents affected by decentralization. We conclude that neuromodulatory inputs to the pyloric network have a novel role in the regulation of ionic current expression. They can control, over the long term, the coordinated expression of multiple voltage-gated ionic currents that they do not acutely modulate. Our results suggest that current coregulation places constraints on neuronal intrinsic plasticity and the ability of a network to respond to perturbations. The loss of conductance coregulation may be a mechanism to facilitate the recovery of function.
Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes. (1996)

The time course of induction of SOS-like stress responses such as enhanced reactivation (ER) and enhanced mutagenesis (EM) has been investigated in UV-C-irradiated skin fibroblasts from a xeroderma pigmentosum (XP) family, using herpes simplex virus type 1 as a probe. Similar ER studies were performed in a Li-Fraumeni syndrome (LFS) family and in a family with a high incidence of breast, ovarian, and colon cancer. In two XP (complementation group B) patients, with a striking absence of skin tumors even at an age of >40 years, only induction of EM was observed, whereas ER was absent (XPER-). The ER- phenotype was inherited from the father, whereas cells from the mother exhibited normal expression of ER and EM. This suggests that the absence of ER is a hereditary trait that is not correlated with a repair-deficient phenotype. Abnormally high levels of ER were observed in UV-C-exposed skin fibroblasts from rive LFS patients. The inheritance of the ER response was studied in one LFS family. High levels of ER were observed only in cells derived from affected individuals carrying one mutated p53 allele, whereas cells from unaffected family members, carrying two wild-type p53 alleles, exhibited normal ER levels. This result shows that abnormally high levels of ER positively correlate with the occurrence of cancer in affected individuals from a LFS family. Interestingly, abnormally high levels of ER were observed in cells from afflicted as well as from unafflicted members of a family with a high incidence of breast, ovarian, colon, and stomach cancer. This suggests that these latter individuals have inherited a mutated, putative predisposing gene, resulting in abnormal expression of ER, but that cancer had not yet developed. The results indicate that the ER response can possibly be used as a prognostic marker to identify carriers in various hereditary cancer-prone syndromes at an early age.
Direct Detection of Genomic DNA by Enzymatically Amplified SPR Imaging Measurements of RNA Microarrays (2004)

A novel surface enzymatic reaction scheme that amplifies the optical response of RNA microarrays to the binding of complementary DNA is developed for the direct detection and analysis of genomic DNA. The enzyme RNase H is shown to selectively and repeatedly destroy RNA from DNA-RNA heteroduplexes on gold surfaces; when used in conjunction with the label-free technique of surface plasmon resonance (SPR) imaging, DNA oligonucleotides can be detected at a concentration of 1 fM. This enzymatically amplified SPR imaging methodology is then utilized to detect and identify the presence of the TSPY gene in human genomic DNA without PCR amplification.
Correction: CNN-Based Pose Estimation System for Close-Proximity Operations Around Uncooperative Spacecraft (2020)

Correction Notice The second metric in table two should be in [deg], and not in [deg/s] The term in Eqn. 17 and Eqn
14C‐Tracerstudien zum Nukleinsäuren‐Stoffwechsel von Jungratten, Küken und Ferkeln1 (1984)

Zusammenfassung Tracerdosen der (2‐ 14 C)‐markierten Pyrimidinnukleoside Uridin, Cytidin und Thymidin wurden einzeln intraperitoneal (i.p.) oder oral an je zwei Ferkel (13–20 Tage alt) pro Tracer und Applikationsart verabreicht. In einem weiteren Versuch wurden zusätzlich sowohl zum i.p. als auch oral applizierten (2‐ 14 C)‐Uridin‐Tracer 200 mg Uridin/kg Körpermasse gegeben, um den Einfluβ der Pyrimidinkonzentration auf den Stoffwechsel zu untersuchen. Die Versuchsdauer betrug in der Regel 24 Stunden, bei einem Einzeltier nach oraler Applikation von (2‐ 14 C)‐Uridin 7 Tage. Nach jeweils 24 Stunden wurde die 14 C‐Ausscheidung über die Atemluft, den Harn und Kot, nach Versuchsende (24 Std. bzw. 7 Tage) der 14 C‐Gehalt im Inhalt des Gastrointestinal‐traktes sowie die 14 C‐Retention im gesamten Tierkörper, im Intestinalgewebe und den inneren Organen (Leber, Nieren, Herz, Lunge, Milz) analysiert. Über den Kot wurden innerhalb von 24 Stunden nur geringe Aktivitätsmengen ausgeschieden, in 7 Tagen waren es 6,7% der über (2‐ 14 C)‐Uridin oral applizierten 14 C‐Dosis. Renal exkretiert wurden ohne Einfluβ der Applikationsart im Mittel 5,4% der 14 C‐Dosis aus Uridin, 2,1% aus Thymidin und 16,2% aus Cytidin. Als 14 C‐Metaboliten im Harn waren nach i.p. Injektion von (2‐ 14 C)‐Uridin nur Uracil (80% des gesamten 14 C im Harn) und Uridin (20%) nachweisbar. Veratmet wurden jeweils höhere 14 C‐Anteile aus den oral verabreichten Tracern, und zwar durchschnittlich 48% der 14 C‐Dosis aus Uridin, 37% aus Cytidin und 50% aus Thymidin. Im Tierkörper retiniert wurden dagegen am stärksten die injizierten Tracer. Nach oraler Applikation war die 14 C‐Retention aus (2‐ 14 C)‐Uridin mit 13% der 14 C‐Dosis am höchsten, nach 7 Tagen waren es allerdings nur noch 3%. Das Intestinalgewebe und die inneren Organe waren im Vergleich zum Restkörper überproportional markiert. Die Verabreichung von 200 mg Uridin/kg Körpermasse zum Uridin‐Tracer verzögerte die 14 CO 2 ‐Veratmung, veränderte sie aber nicht quantitativ. Die relative 14 C‐Retention im Tierkörper wurde durch die hohe Uridingabe herabgesetzt. Die Versuchsergebnisse zum Pyri‐midinmetabolismus wurden im Tierartenvergleich ‐ junge Ratte, Küken, Ferkel ‐ diskutiert.