gebhart/patrepeval huggingface dataset:
Glutathione Dependence of Caspase-8 Activation at the Death-inducing Signaling Complex (2002)

Apoptosis triggered by the death receptor CD95 (APO-1 or Fas) is pivotal for the homeostasis of the immune system. We investigated differential effects of glutathione depletion on CD95-triggered apoptosis in T and B cell lines as well as the glutathione dependence of caspase-8 activation. In B lymphoblastoid SKW6.4 cells, CD95-mediated apoptosis was prevented upstream of caspase-8 activation and caspase-3-like activity after acute glutathione depletion by diethyl maleate or cis-chloro-dinitrobenzene. Immunoprecipitation of the death-inducing signaling complex (DISC) revealed that the DISC was still formed in the glutathione-depleted state. The first cleavage step of procaspase-8 activation at the DISC, however, was inhibited. Accordingly, under cell-free conditions, radiolabeled procaspase-8 was processed at the immunoprecipitated DISC only after the addition of exogenous dithiothreitol or reduced glutathione. We also observed suppression of CD95-mediated apoptosis in glutathione-depleted CEM and H9 cells. Notably, Jurkat cells still died upon CD95 engagement under this condition, displaying incomplete nuclear fragmentation and a partial switch to necrosis; this may be explained by reduced cytochrome c/dATP-mediated caspase activation observed in cytosol from glutathione-depleted Jurkat cytosol. Our data indicate that the activation of caspase-8 at the DISC and hence CD95-mediated apoptosis induction shows a cell-specific requirement for intracellular glutathione.
A new RF capacitance method to extract the effective channel length of MOSFET's using S-parameters (2002)

A simple and accurate extraction of the effective channel length is carried out by utilizing the slope information of the the intrinsic gate-to-channel capacitance versus the mask gate length of ultra short-channel devices. The measurement setup where the gate is connected to a RF signal is used to remove the discrepancy problem between conventional I-V and C-V methods. In order to increase the measurement accuracy, the intrinsic gate-to-channel capacitance data are determined by calibrating S-parameter sets measured at GHz using zero-bias data, instead of low-frequency C-V measurements. Contrary to the conventional C-V method, this new RF C-V method results in much smaller deviation from the I-V method.
Clinical Sports Medicine (1993)

This volume is another comprehensive and authoritative publication for the Encyclopaedia of Sports Medicine, the result of collaboration between the IOC Medical Commission and the International Federation of Sports Medicine.The editors present a well organized total of 57 contributions, grouped into seven different sections, covering many aspects of aerobic endurance and its application to sport.The first section contains semantic and physiological definitions and notes that the lengths both of competition and of training determine whether an event can be classified as 'endurance'.The second section, entitled 'General Scientific Considerations' consists of . . .
Statistical carbazole–fluorene–TTBTBTT terpolymers as promising electron donor materials for organic solar cells (2015)

We report the application of a statistical Suzuki-Miyaura polycondensation reaction for synthesis of a family of carbazole-fluorene-TTBTBTT terpolymers with tailored physical and optoelectronic properties. Organic bulk heterojunction solar cells based on the designed materials with optimal fluorene to carbazole ratios yielded reproducible power conversion efficiencies of 6.5-6.7%.
Text Mining Emergent Human Behaviors for Interactive Systems (2015)

People engage with thousands of situations, activities, and objects on a daily basis. Hand-coding this knowledge into interactive systems is prohibitively labor-intensive, but fiction captures a vast number of human lives in moment to moment detail. In this paper, we bootstrap a knowledge graph of human activities by text mining a large dataset of modern fiction on the web. Our knowledge graph, Augur, describes human actions over time as conditioned by nearby locations, people, and objects. Applications can use this graph to react to human behavior in a data-driven way. We demonstrate an Augur-enhanced video game world in which non-player characters follow realistic patterns of behavior, interact with their environment and each other, and respond to the user's behavior.
Fabrication of Cladded Single Crystal Fibers for All-Crystalline Fiber Lasers (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text L. B. Shaw, S. Bayya, W. Kim, J. Myers, D. Rhonehouse, S. N. Qadri, C. Askins, J. Peele, R. Thapa, D. Gibson, R. R. Gattass, J. Kolis, B. Stadelman, and J. S. Sanghera, "Fabrication of Cladded Single Crystal Fibers for All-Crystalline Fiber Lasers," in Advanced Photonics 2018 (BGPP, IPR, NP, NOMA, Sensors, Networks, SPPCom, SOF), OSA Technical Digest (online) (Optica Publishing Group, 2018), paper SoW2H.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Design and control of a novel mechatronic tracheostomy tube-inserted suction catheter for automated tracheal suctioning (2015)

Mechanical ventilation is required to aid patients with breathing difficulty to breathe more comfortably. A tracheostomy tube is inserted through an opening in the patient neck into the trachea, below the vocal cords. This opening is either created surgically or using a percutaneous dilatational technique. The inserted tube sits in the trachea, above the carina, and before the airways branch into the left and right main bronchi. In mechanical ventilation, the tube is connected to a ventilator and air is moved in and out of the lungs via positive pressure. In this process, mucus will accumulate at the point of branching into the branchi. Currently, this mucus is manually removed half-hour by inserting a suction tube via the tracheostomy to reach the point of branching. Nurses spend millions of person-hours to perform this task yearly. To save significant person-hours, an automated system is needed. This system also allows the patient to recover at home, rather stay in hospital solely for nurses to remove mucus periodically. In this paper, we present a novel mechatronic device to perform automatic tracheal suctioning in conjunction with a tracheostomy tube. A new suctioning catheter is also developed. It is known that nonlinear friction and backlash between the suctioning catheter and its conduit as well as in the gear system of the actuator cause difficulties to accurately control the position of catheter tip. To enhance the system performances, a novel direct inverse of backlash-like hysteresis model-based feedforward is also developed. The designed device and proposed compensation scheme are experimentally validated. The results demonstrate a significant contribution and potential benefits to the mechanical ventilation works.
Image analysis of paintings by computer graphics synthesis: an investigation of the illumination in Georges de la Tour's Christ in the carpenter's studio (2008)

Computer graphics models of tableaus in paintings provide a principled and controlled method for exploring alternate explanations of artists' praxis. We illustrate the power of computer graphics by testing the recent claim that Georges de la Tour secretly built an optical projector to execute Christ in the carpenter's studio, specifically that he traced projected images in two "exposures," with the illuminant in a different position in each. The theory's originator adduces as evidence his informal impressions that the shadows and highlights in the depicted image imply that the illuminant is in positions other than that of the depicted candle. We tested this projection claim by creating a computer graphics model of the tableau and adjusting the location of the model's illuminants so as to reproduce as closely as possible the pattern of shadows and highlights in the depicted scene. We found that for one "exposure" the model illuminant was quite close to the depicted candle, rather than in the position demanded by the projection theory. We found that for the other "exposure" no single illuminant location explained all highlights perfectly but the evidence was most consistent with the illuminant being in the location of the candle. Our simulation evidence therefore argues against the projection theory for this painting, a conclusion that comports with those from earlier studies of this and other paintings by de la Tour. We conclude with general lessons and suggestions on the use of computer graphics in the study of two-dimensional visual art.
The Evaluation of ACTH-Dependent Cushingʼs Syndrome (1999)

The causes of endogenous Cushing's syndrome include primary excess ACTH production (ACTH-dependent forms) and primary adrenal Cortisol production. Because hypercortisolism suppresses normal ACTH secretion, ACTH levels are low in the primary adrenal forms and are normal or increased in patients with ACTH-dependent Cushing's syndrome. Excess ACTH production by a pituitary corticotrope tumor, termed Cushing's disease, is more common (80%) than nonpituitary, or “ectopic,” ACTH secretion (20%). Most patients with ectopic ACTH secretion cannot be differentiated clinically from those with Cushing's disease, so biochemical tests must be used. Inferior petrosal sinus sampling can identify a pituitary source of ACTH because of the increase in petrosal ACTH concentration compared with peripheral blood. This test has near 100% diagnostic accuracy, but it is costly and invasive. The corticotropin-releasing hormone stimulation test and overnight 8 mg dexamethasone suppression test lack these drawbacks, but they have less sensitivity for Cushing's disease (93% and 71%, respectively) when cutpoints that exclude all patients with ectopic ACTH secretion are used. MRI of the pituitary gland reveals a tumor in about 50% of patients with Cushing's disease; conversely, imaging of the chest and abdomen is essential for localizing tumors producing ACTH ectopically.
Fracture apertures from electrical borehole scans (1990)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1990Fracture apertures from electrical borehole scansAuthors: Stepan M. LuthiPhilippe SouhaiteStepan M. LuthiSchlumberger‐Doll Research and Philippe SouhaiteSchlumberger (retired), Francehttps://doi.org/10.1190/1.1890143 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1890143FiguresReferencesRelatedDetailsCited ByUltra-Deep Dolomite Reservoir Quality Classification and its Effect on Acid-Fracturing Based on Natural Fracture Activity Analysis: A Case Study of the Cambrian Subsalt Reservoir in Northern Uplift of Tarim Basin23 June 2022 | Frontiers in Earth Science, Vol. 10Dynamic Data Integration in Dual-Porosity Dual-Permeability Reservoirs: Permeability Conditioning Perspective21 March 2022Characterizing natural fractures productivity in tight gas reservoirs10 July 2012 | Journal of Petroleum Exploration and Production Technology, Vol. 2, No. 2 SEG Technical Program Expanded Abstracts 1990ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1990 Pages: 1779 publication data© 1990 Copyright © 1990 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Stepan M. Luthi and Philippe Souhaite, (1990), "Fracture apertures from electrical borehole scans," SEG Technical Program Expanded Abstracts : 18-21. https://doi.org/10.1190/1.1890143 Plain-Language Summary PDF DownloadLoading ...
VELVET ANTLER POLYPEPTIDES PROMOTED PROLIFERATION OF EPIDERMIC CELLS AND FIBROBLASTS AND SKIN WOUND HEALING (2001)

AIM To study the effects of total velvet antler polypeptides (TVAP), native VAP (nVAP) and synthetic VAP (sVAP) on proliferation of epidermic cells and fibroblasts. METHODS Newborn rat epidermic cells and rabbit chontrocytes were incubated in culture medium containing TVAP or nVAP and sVAP. [ 3H]TdR incorporation into DNA was measured. Skin wound healing-promoting action of TVAP was determined in rats. RESULTS TVAP ointment 0 8 and 3 2 mg·g -1 by external application accelerated healing of rat backskin wound. The wound-remaining rate of TVAP-treated group was lower (7 08%±4 57%) than that of the control group (16 16%±6 52%) ( P 0 01) at the 17th day after treatment. nVAP 0 4, 2, 10 and 50 mg·L -1 showed most marked proliferation-promoting activity for rat epidermic cells and increased incorporation of [ 3H]TdR from (27±10) Bq (control group) to (112±32), (178±43), (271±48) and (323±32) Bq, respectively ( P 0 01 or P 0 001). It showed that nVAP from TVAP is the main active polypeptide responsible for proliferation of epidermic cells and skin wound healing. sVAP also showed stimulating effect on epidermic cells and fibroblasts. CONCLUSION TVAP accelerated skin wound healing by stimulating proliferation of epidermic cells and fibroblasts.
Correcting Comma Errors in Learner Essays, and Restoring Commas in Newswire Text (2012)

While the field of grammatical error detection has progressed over the past few years, one area of particular difficulty for both native and non-native learners of English, comma placement, has been largely ignored. We present a system for comma error correction in English that achieves an average of 89 % precision and 25 % recall on two corpora of unedited student essays. This system also achieves state-of-theart performance in the sister task of restoring commas in well-formed text. For both tasks, we show that the use of novel features which encode long-distance information improves upon the more lexically-driven features used in prior work. 1
Tyzx DeepSea High Speed Stereo Vision System (2005)

This paper describes the DeepSea Stereo Vision System which makes the use of high speed 3D images practical in many application domains. This system is based on the DeepSea processor, an ASIC, which computes absolute depth based on simultaneously captured left and right images with high frame rates, low latency, and low power. The chip is capable of running at 200 frames per second with 512x480 images, with only 13 scan lines latency between data input and first depth output. The DeepSea Stereo Vision System includes a stereo camera, onboard image rectification, and an interface to a general purpose processor over a PCI bus. We conclude by describing several applications implemented with the DeepSea system including person tracking, obstacle detection for autonomous navigation, and gesture recognition.
Unique ζ‐chain motifs mediate a direct TCR‐actin linkage critical for immunological synapse formation and T‐cell activation (2013)

TCR-mediated activation induces receptor microclusters that evolve to a defined immune synapse (IS). Many studies showed that actin polymerization and remodeling, which create a scaffold critical to IS formation and stabilization, are TCR mediated. However, the mechanisms controlling simultaneous TCR and actin dynamic rearrangement in the IS are yet not fully understood. Herein, we identify two novel TCR ζ-chain motifs, mediating the TCR's direct interaction with actin and inducing actin bundling. While T cells expressing the ζ-chain mutated in these motifs lack cytoskeleton (actin) associated (cska)-TCRs, they express normal levels of non-cska and surface TCRs as cells expressing wild-type ζ-chain. However, such mutant cells are unable to display activation-dependent TCR clustering, IS formation, expression of CD25/CD69 activation markers, or produce/secrete cytokine, effects also seen in the corresponding APCs. We are the first to show a direct TCR-actin linkage, providing the missing gap linking between TCR-mediated Ag recognition, specific cytoskeleton orientation toward the T-cell-APC interacting pole and long-lived IS maintenance.
Optimized THz Systems for Imaging and Spectroscopic Applications (2006)

It is shown how geometrical optical optimization with ZEMAX can be used to achieve diffraction limited THz systems with the highest possible resolution.
Optimization of unit setting of processes of high-temperature hard-alloy material synthesis (2015)

Technologies of self-propagating high-temperature synthesis (SHS) are rapidly gaining popularity due to considerable advantages over their alternatives (furnace and plasma chemical synthesis, baking and hot compaction, molding and hard-surfacing, etc.). These technologies are implementation of natural heat energy; simplicity and reliability of unit settings for the process of SHS compaction because of absence of external heat sources; high process speed, resulting from the self-heating of charge in a combustion wave; layer-wise heat evolution and, consequently, a possibility to increase the process equipment capacity. In SHS compaction, hard-alloy materials are formed in a short period of time (t = [0,5&hellip;15] s) at high temperature t = [2000&hellip;3000] oС) and pressure (P = 100 MPa). In this case, a high temperature gradient in mould cylindrical wall (as well as thermoelastic stress) is the result of uneven thermal loadings and non-stationary mode of heat conductivity process. Using a mathematical model of processes of self-propagating high-temperature synthesis (SHS) of hard-alloy materials and their compaction (SHS-compaction), an original method of cost-efficient analysis of unit settings for these processes was developed, which allows to reduce the consumption rate of structural material for tooling and industrial equipment by 25% on average. A one-stage problem of stochastic optimization of unit setting of SHS-compaction process of hard-alloy materials brands STIM-2A and STIM-2/30N was defined and solved under the interval uncertainty of speed and furnace feed temperature. Press mold structure with minimal structural material consumption rate was designed, which provides the quality production of hard-alloy materials STIM-2A and STIM-2/30N regardless of random changes in uncertain parameters of SHS-compaction process (combustion speed and temperature) within the given limits.
Activity of rifapentine and its metabolite 25-O-desacetylrifapentine compared with rifampicin and rifabutin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M. bovis BCG (2000)

The in vitro activity of rifapentine and its metabolite, 25-O:-desacetylrifapentine, as compared with that of rifampicin and rifabutin, was determined against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M. bovis BCG. MICs were determined radiometrically and by the 1% proportional method using Middlebrook 7H11 agar. The bactericidal effect of the drugs was determined in parallel at selected concentrations. For drugsusceptible isolates of M. tuberculosis, the Bactec MICs of rifapentine and 25-O:-desacetylrifapentine were 0.03-0.06 mg/L and 0. 125-0.25 mg/L, respectively. Similar MICs were obtained for M. africanum (0.03-0.125 and 0.125-0.50 mg/L, respectively), and M. bovis (0.063-0.25 and 0.125-1.0 mg/L, respectively), but MICs were considerably lower for M. bovis BCG (0.008-0.063 mg/L for rifapentine and 0.016-0.125 mg/L for its metabolite). In general, MICs determined using 7H11 agar medium were usually one or two dilutions higher than those obtained using Bactec broth. When compared with rifampicin and rifabutin, the inhibitory activity of rifapentine for drug-susceptible isolates was roughly equal to that of rifabutin, and the inhibitory activity of 25-O:-desacetylrifapentine was comparable to that of rifampicin; however, rifapentine was somewhat more bactericidal than rifabutin at equal concentrations. Clinical isolates of M. tuberculosis with a high degree of resistance to rifampicin (MIC >/= 32 mg/L) were also highly resistant to rifabutin, rifapentine and 25-O:-desacetylrifapentine, although the MICs of rifabutin in this case were somewhat lower than the MICs of rifapentine.
ChemInform Abstract: DNA with Altered Bases (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Cyanobacterial Toxin Cylindrospermopsin Inhibits Pyrimidine Nucleotide Synthesis and Alters Cholesterol Distribution in Mice (2004)

The hepatotoxin Cylindrospermopsin, a sulfated-guanidinium alkaloid with substituted dioxypyrimidine (uracil) moiety, was isolated from several cyanobacteria species. Our previous studies on the toxicity of cylindrospermopsin and its derivatives suggested that the uracil moiety is crucial for the toxicity and that such toxicity could partly stem from competitive binding of the toxin to a catalytic site(s) involved in the synthesis of pyrimidine nucleotides (i.e., uridine). In the present study we demonstrated that cylindrospermopsin inhibited in a noncompetitive manner the in vitro activity of uridine monophosphate (UMP) synthase complex (responsible for the conversion of orotic acid to UMP) in a cell free liver extract from mice, with an inhibition constant, KI, of 10 microM. Exposure of mice to cylindrospermopsin at subacute concentrations, via drinking water, only slightly affected the in vitro activity of UMP synthase. The typical metabolic disorder associated with the inhibition of UMP synthase activity, known as "orotic aciduria," was not observed under these conditions, but other anomalous metabolic responses related to cholesterol metabolism were developed.
Scanning the Issue (2023)

Vehicle platooning has become a topic of substantial interest for the development of safer and more efficient means of transportation. It is described as a string of connected autonomous vehicles traveling closely, maintaining certain inter-vehicular distances at a set speed boosting the road capacity, improving safety, and lowering adverse environmental significance. Several platooning concepts are revealed. A unified integrated platoon control architecture is constructed, employing the aforementioned concepts. Several control algorithms are investigated, optimized, and compared to manage the longitudinal inter-vehicular spacing distances of a formed platoon, as well as the lateral platoon motion tracking. The outperformed controllers are utilized in an integrated platooning scenario. Simulations are visualized using the multi-robot systems intelligent transportation systems (MRS-ITSs) visualization tool for further realization of the results.
New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food (2023)

The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome's definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS.