gebhart/patrepeval huggingface dataset:
[Combination of hemofiltration and peritoneal dialysis in the treatment of severe acute pancreatitis]. (2004)

The above results show that the cytokines overproduced during the development of SAP can be removed effectively from the circulation and the fluid filtrated by means of HF + PD. The continual deterioration of the local focus and systemtic presentation could be prevented effectively too, and the earlier the treatment of HF + PD, the better the prognosis.
A 3.6 mW, 90 nm CMOS Gated-Vernier Time-to-Digital Converter With an Equivalent Resolution of 3.2 ps (2012)

Two gated ring oscillators (GROs) act as the delay lines in an improved Vernier time-to-digital converter (TDC), where the already small quantization noise of the standard Vernier TDC is further first-order shaped by the GRO operation. The TDC has been implemented in a 90 nm CMOS process and consumes 3 mA from 1.2 V when operating at 25 MHz. The native Vernier resolution of the TDC is 5.8 ps, while the total noise integrated over a bandwidth of 800 kHz yields an equivalent TDC resolution of 3.2 ps.
Azimuthal Anchoring Properties of Nematic Liquid Crystal on UV-Exposed Polyimide Layers (2002)

The azimuthal anchoring properties of a nematic liquid crystal (LC) on two kinds of UV-exposed polyimide (PI) layers with different LC wettabilities have been examined. The azimuthal anchoring state of the PI layer showing a high LC wettability is revealed to be stronger than that showing a low LC wettability, which results from the strong LC adsorption state in the polymer showing a high LC wettability. These results indicate the important contribution of LC wettability to the azimuthal LC anchoring even in a photoalignment method. We also point out that the derivation of the azimuthal anchoring energy from a twist angle measurement is questionable due to the movement of the easy axis in a twisted nematic sample.
Autoencoders as Tools for Program Synthesis (2021)

Recently there have been many advances in research on language modeling of source code. Applications range from code suggestion and completion to code summarization. However, complete program synthesis of industry-grade programming languages remains an open problem. In this work, we introduce and experimentally validate a variational autoencoder model for program synthesis of industry-grade programming languages. This model makes use of the inherent tree structure of code and can be used in conjunction with gradient free optimization techniques like evolutionary methods to generate programs that maximize a given fitness function, for instance, passing a set of test cases. A demonstration is avaliable at https://tree2tree.app
Electrochemistry as an Attractive and Effective Tool for the Synthesis and Immobilization of Porphyrins on an Electrode Surface (2015)

Magnesium(II) 10-phenyl-5,15-p-ditolylporphyrin is easily and cleanly transformed by electrolysis. A nitro group is first introduced at the free meso position by anodic substitution. Hydrogenation into the amine is then carried out electrocatalytically under ambient conditions with water as a hydrogen supplier. The synthesized porphyrin under the nickel(II) form can be covalently grafted onto a platinum electrode by electrochemical reduction of the diazonium cation, generated in situ by a reaction of the nickel(II) aminoporphyrin with sodium nitrite and trifluoroacetic acid. The electrosynthesized thin film gives an electrochemical response typical of a porphyrin material. Films grown under our conditions have a maximum surface coverage of approximately 5×10(-10) mol cm(-2). The modified electrode exhibits a reproducible electrochemical behavior and a good level of stability over potential cycling and exposition to air.
Influence of water on the mechanical properties of wood investigated using X-ray and neutron scattering (2006)

Holz ist ein Verbundwerkstoff der hauptschlich aus steifen
Fast Reconstruction Algorithm for Perturbed Compressive Sensing Based on\n Total Least-Squares and Proximal Splitting (2016)

We consider the problem of finding a sparse solution for an underdetermined\nlinear system of equations when the known parameters on both sides of the\nsystem are subject to perturbation. This problem is particularly relevant to\nreconstruction in fully-perturbed compressive-sensing setups where both the\nprojected measurements of an unknown sparse vector and the knowledge of the\nassociated projection matrix are perturbed due to noise, error, mismatch, etc.\nWe propose a new iterative algorithm for tackling this problem. The proposed\nalgorithm utilizes the proximal-gradient method to find a sparse total\nleast-squares solution by minimizing an l1-regularized Rayleigh-quotient cost\nfunction. We determine the step-size of the algorithm at each iteration using\nan adaptive rule accompanied by backtracking line search to improve the\nalgorithm's convergence speed and preserve its stability. The proposed\nalgorithm is considerably faster than a popular previously-proposed algorithm,\nwhich employs the alternating-direction method and coordinate-descent\niterations, as it requires significantly fewer computations to deliver the same\naccuracy. We demonstrate the effectiveness of the proposed algorithm via\nsimulation results.\n
New (CH)8 isomer, tetracyclo[4.2.0.02,4.03,5]oct-7-ene (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNew (CH)8 isomer, tetracyclo[4.2.0.02,4.03,5]oct-7-eneGeorge E. Gream, Leverett R. Smith, and Jerrold MeinwaldCite this: J. Org. Chem. 1974, 39, 23, 3461–3462Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://doi.org/10.1021/jo00937a056Request reuse permissionsArticle Views47Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (285 KB) Get e-Alertsclose Get e-Alerts
AIBN as an Electrophilic Reagent for Cyano Group Transfer (2023)

AIBN is a convenient electrophilic cyanation reagent for transforming ArLi into ArCN under mild conditions. The addition/fragmentation cascade is controlled by Li···N chelation in which AIBN nitrogens assist in the nearly barrierless fragmentation into the desired ArCN product. Acidic C-H bonds in the fragmented byproduct partially consume ArLi by protonation. Density functional theory calculations and isotopic labeling probe the mechanism and explain the switch to substituted hydrazones in reactions with BuLi.
A neural network approach to interactive content-based retrieval of video databases (1999)

A neural network scheme is presented in this paper for adaptive video indexing and retrieval. First, a limited but characteristic amount of frames are extracted from each video scene, by minimizing a cross-correlation criterion. Low level features are extracted to indicate the frame characteristics, such as color and motion segments. This is due to the fact that extraction of high-level, semantic, features from any kind of images is too hard to be implemented. After the key frame extraction, the video queries are implemented directly on this small number of frames. To reduce, however, the limitation of low-level features the human is considered as a part of the process, meaning that he/she is able to assign a degree of appropriateness for each retrieved image of the system and then restart the searching. A feedforward neural network structure is proposed as a parametric distance for the retrieval, mainly due to the highly non linear capabilities. An adaptation mechanism is also proposed for updating the network weights, each time a new image selection is performed by the user. This mechanism can modify the network weights so that the output of the network, after the adaptation, is as much as close to the user's selection while simultaneously performing a minimal degradation of the previous learned data.
Virtually Bette™ Virtual Reality System (1998)

The application of virtual reality (VR) technology to psychiatry and clinical psychology is a new treatment modality that promises to revolutionize many aspects of the clinical care industry. Virtually Better™ (Virtually Better, Inc., Atlanta, GA) is a virtual reality exposure therapy system designed to reduce fear and avoidance in phobic patients. Virtually Better consists of custom VR software and models of virtual environments that have been carefully designed to support exposure therapy of anxiety disorders. Virtually Better therapy systems combine recent research and technological advances in Virtual Reality with the most advanced developments and clinical practice in exposure therapy.
Antitumor immune response induced by NBTXR3 activated by radiotherapy. (2019)

e14609 Background: Radiotherapy (RT) can prime an anti-tumor immune response. Unfortunately, this response rarely generates total tumor destruction and abscopal effect. When activated by RT, intratumorally (IT) administered hafnium oxide nanoparticles (NBTXR3) locally increase radiation dose deposit and tumor cell death compared to RT alone. We hypothesized that NBTXR3 + RT could enhance the anti-tumor immune response, both in mice and humans. Methods: Murine CT26 cells were injected in both flanks of immunocompetent mice. When tumor volume reached 50-120mm3, NBTXR3 (or vehicle) was injected IT in right flank tumors only, then irradiated (3x4Gy). Mice were sacrificed when tumors reached 800mm3. Alternatively, tumors were collected 3 days after last RT fraction and immune cell infiltrates analyzed by immunohistochemistry (IHC). Patients (pts) with locally advanced Soft Tissue Sarcoma (STS) (NCT02379845) received NBTXR3 + RT or RT alone. Pre- and post-treatment (biopsy and resection, respectively) tumor tissues from pts were analyzed by IHC and Digital Pathology for immune biomarkers ( &gt; 16 pts per arm). Results: In mice, IHC analyses showed an increase of CD8+ T cells infiltrates in both flanks of mice treated with NBTXR3+RT, while this was not observed in animals treated with RT alone. Furthermore, ICH analysis of post- vs pre-treatment samples from STS pts showed a marked increase of CD8+ and PD1 biomarkers for pts treated with NBTXR3 + RT, while no differences were seen for pts treated with RT alone. Conclusions: NBTXR3 + RT markedly changes the tumor immune profile in a similar manner in mice and pts with STS. We hypothesize that this adaptive immune response could help convert a local tumor microenvironment to a “hot” phenotype and thus improve the efficacy of immune checkpoint inhibitors. These results led us to investigate the safety and systemic effect of NBTXR3 activated by stereotactic ablative RT (SABR) in combination with anti-PD-1 antibody in pts with locoregionally recurrent or metastatic (to lung or liver) Head and Neck squamous cell carcinoma HNSCC, as well as in metastatic non-small cell lung cancer (NSCLC) and liver metastasis patients [NCT03589339].
Methodological interference of biochar in the determination of extracellular enzyme activities in composting samples (2014)

Abstract. Biochar application has received increasing attention as a means to trap recalcitrant carbon and enhance soil fertility. Hydrolytic enzymatic assays, such as β-glucosidase and phosphatase activities, are used for the assessment of soil quality and composting process, which are based on use of p-nitrophenol (PNP) derivatives as substrate. However, sorption capacity of biochar can interfere colorimetric determination of the hydrolysed PNP, either by the sorption of the substrate or the reaction-product of hydrolysis into biochar surface. The aim of the present work is to study the biochar sorption capacity for PNP in biochar-blended composting mixtures in order to assess its impact on the estimation of the colorimetric-based enzymatic assays. A retention test was conducted by adding a solution of known amounts of PNP in universal buffer solution (pH = 5, 6.5 and 11, corresponding to the β-glucosidase, acid and alkaline phosphatase activity assays, respectively), in samples taken at the initial stage and after maturation stage from 4 different composting piles (two manure composting piles (PM: poultry manure, CM: cow manure) and two other similar piles containing 10% of additional biochar (PM + B, CM + B)). The results show that biochar blended composts (PM + B, CM + B) generally exhibited low enzymatic activities, compared to manure compost without biochar (PM, CM). In terms of the difference between the initial and maturation stage of composting process, the PNP retention in biochar was shown more clearly at maturation stage, caused by an enlarged proportion of biochar inside compost mixture after the selective degradation of easily decomposable organic matter. The retention of PNP was more pronounced at low pH (5 and 6.5) than at high pH (11), 3 reflecting on pH dependency of sorption 49 capacity of biochar and/or PNP 50 solubility.
Compounds binding to cytoskeletal proteins are active against (1989)

The effects of nine different tubulin-binding substances and of one actin-binding compound, cytochalasin B, upon the intraerythrocytic development of the malaria parasite Plasmodium falciparum were investigated in vitro. From the data obtained, plasmodial tubulins seem to be quite different from the mammalian proteins on the molecular level. Tubulozole-T, a substance which is inactive in mammalian systems, appears to be a promising novel antimalarial drug.
Nonintrusive characterization of long-fiber-link birefringence (2008)

We propose a technique for estimating the birefringence correlation length and beat length of a long fiber link based on the measurement of two parameters only, the mean differential group delay and the mean Faraday rotation of a fiber with a small magnetic field applied. The two parameters can be measured without the need of cutting the fiber.
A novel side‐chain‐linked antiparallel cyclic dimer of enkephalin (1985)

The dimeric cyclic enkephalin analog, (H-Tyr-D-Lys-Gly-Phe-Glu-NH2)2, was isolated as a second major component from the crude product obtained in a solid-phase synthesis of the corresponding cyclic monomer, H-Tyr-D-Lys-Gly-Phe-Glu-NH2. In comparison with [Leu5]enkephalin the cyclic dimer is about equipotent in assays representative for mu-opioid receptor interactions and 1/10 as potent at the delta-receptor. The fact that the enkephalin dimer shows a receptor selectivity pattern distinct from that of the cyclic monomer and of the corresponding linear analog suggests that cyclodimerization via side-chain linkages might be generally useful as a means to produce shifts in the activity profiles of peptide hormones and neurotransmitters.
Comparison of Different Anti-Demodex Strategies: A Systematic Review and Meta-Analysis (2022)

We found ivermectin (topical and systemic), ivermectin-metronidazole (topical), and TTO (topical) are promising anti-Demodex interventions. In addition to traditional pharmacotherapy, light therapies, especially IPL and skin cleansing, could also be considered as effective methods to control Demodex mite infestation.
Localization of platelet osteonectin at the internal face of the alpha- granule membranes in platelets and megakaryocytes (1992)

Osteonectin is a 32-Kd phosphoglycoprotein originally described in bone but also found in platelets. Platelet and bone osteonectin are different both structurally and immunologically. We have previously shown that platelet osteonectin, by binding to thrombospondin, is involved in the secretion-dependent phase of the platelet aggregation process. In this study, we used antiosteonectin antibodies in combination with immunogold labeling to investigate by electron microscopy the fine localization of osteonectin within normal and gray platelets. Using both a polyclonal and monoclonal antibody ON3, osteonectin was specifically located at the internal face of alpha-granule membranes within normal platelets. Osteonectin was not distributed within all alpha-granules, probably because of its low platelet content. In addition, using immunofluorescence, osteonectin could also be detected in immature and mature megakaryocytes with a granular pattern of staining, suggesting that osteonectin is synthesized by megakaryocytes. Using platelets from two patients with gray platelet syndrome, osteonectin was absent within all abnormal small alpha-granules, but was detected in some rare normal-sized alpha-granules. In separate double-label studies, thrombospondin and von Willebrand factor did not colocalize with osteonectin in resting platelets. However, osteonectin was located at the inner face of the alpha-granules, as it is for alpha-granule membrane protein GMP-140 and glycoprotein IIb-IIIa. These results, taken together with the fact that monoclonal antibodies to osteonectin bind only to the surface of activated platelets, suggest that platelet osteonectin is redistributed to the cell surface during fusion of alpha-granule membranes with the plasma membrane.
Early intervention services in daily family life: mothers' perceptions of ‘ideal’ versus ‘actual’ service provision (1998)

Abstract Although the occupational therapy and early intervention literature espouses a family‐centred approach to intervention, families have rarely been asked about their experiences of these services. This paper describes a qualitative study that aimed to identify and explore parents' perceptions of occupational therapy services and the impact of these services in their daily family life. Ten mothers of children (aged 0–6 years) with disabilities and high support needs completed questionnaires and semi‐structured, in‐depth interviews. Analysis revealed that mothers thought in terms of early intervention services in general, rather than in terms of occupational therapy specifically. Mothers used early intervention services primarily to enhance their child's abilities, while considering what was best for their family and, as a lesser priority, themselves. Ideally, relaxed and friendly service providers were perceived as having a greater insight into daily family life, and therefore a greater capacity to provide services to meet family needs (e.g., flexible, home‐based services). However, the mothers in this study did not experience many ‘ideal’ characteristics of services and service providers, suggesting that changes are needed in occupational therapy practice and in the education of therapists. Implications for occupational therapy education and practice are discussed in the context of the family‐centred literature, and recommendations are made for future research with families. Copyright © 1998 Whurr Publishers Ltd.
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease (2001)

Individuals currently characterized as having MCI progress steadily to greater stages of dementia severity at rates dependent on the level of cognitive impairment at entry and they almost always have the neuropathologic features of AD. We conclude that MCI generally represents early-stage AD.
Management of infant born to HIV-positive mother (2013)

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Photo courtesy of the Centers for Disease Control and Prevention 

Scanning electron micrograph shows HIV-1 virions (green spheres) budding from a cultured lymphocyte (yellow cell).

A male infant is born by vaginal delivery after 39 weeks’ gestation to a 26-year-old HIV-
Personalized information management for Web intelligence (2003)

Web intelligence can be defined as the process of scanning and tracking information on the World Wide Web so as to gain competitive advantages. This paper describes a system known as Flexible Organizer for Competitive Intelligence (FOCI) that transforms raw URLs returned by internet search engines into personalized information portfolios. FOCI builds information portfolios by gathering and organizing online information according to a user's needs and preferences. Through a novel method called User-Configurable Clustering, a user can personalize his/her portfolios in terms of the content as well as the information structure. The personalized portfolios can then be used to track new information and organize them into appropriate folders accordingly. We show a sample session of FOCI which illustrates how a user may create and personalize an information portfolio according to his/her preferences and how the system discovers novel information groupings while organizing familiar information according to the user-defined themes.
Science & Technology Review June 2015 (2015)

At Lawrence Livermore National Laboratory, we focus on science and technology research to ensure our nation's security. We also apply that expertise to solve other important national problems in energy, bioscience, and the environment.
Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance (2019)

We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. Our results indicate that response to cisplatin in TNBC has a complex foundation based on impact of treatment on distinct cellular pathways. We find that examination of expression data in the context of heterogeneous data such as drug-gene interactions leads to a better understanding of mechanisms at work in cancer therapy response.
Multidimensional characterization of a new antifouling xanthone: Structure-activity relationship, environmental compatibility, and immobilization in marine coatings (2021)

The accumulation of marine biofouling on ship hulls causes material damage, the spread of invasive species, and, indirectly, an increase in full consumption and subsequent pollutant gas emissions. Most efficient antifouling (AF) strategies rely on the conventional release of persistent, bioaccumulative, and toxic biocides incorporated in marine coatings. A simple oxygenated xanthone, 3,4-dihydroxyxanthone (1), was previously reported as a promising AF agent toward the settlement of Mytilus galloprovincialis larvae, with a therapeutic ratio higher than the commercial biocide Econea®. In this work, a structure-AF activity relationship study, an evaluation of environmental fate, and an AF efficiency in marine coatings were performed with compound 1. Hydroxy or methoxy groups at 3 and 4 positions in compound 1 favored AF activity, and groups with higher steric hindrances were detrimental. Compound 1 demonstrated low water-solubility and a short half-life in natural seawater, contrary to Econea®. In silico environmental fate predictions showed that compound 1 does not bioaccumulate in organism tissues, in contrast to other current emerging biocides, has a moderate affinity for sediments and slow migrates to ground water. No toxicity was observed against Vibrio fischeri and Phaeodactylum tricornutum. Polyurethane-based marine coatings containing compound 1 prepared through an innovative non-release-strategy were as efficient as those containing Econea® with low releases to water after 45 days. This proof-of-concept helped to establish compound 1 as a promising eco-friendly AF agent.