gebhart/patrepeval huggingface dataset:
Enantioselective Degrader for Elimination of Extracellular Aggregation-Prone Proteins hIAPP Associated with Type 2 Diabetes (2023)

Targeted protein degradation has demonstrated the power to modulate protein homeostasis. For overcoming the limitation to intracellular protein degradation, lysosome targeting chimeras have been recently developed and successfully utilized to degrade a range of disease-relevant extracellular and membrane proteins. Inspired by this strategy, here we describe our proof-of-concept studies using metallohelix-based degraders to deliver the extracellular human islet amyloid polypeptide (hIAPP) into the lysosomes for degradation. Our designed metallohelix can bind and inhibit hIAPP aggregation, and the conjugated tri-GalNAc motif can target macrophage galactose-type lectin 1 (MGL1), yielding chimeric molecules that can both inhibit hIAPP aggregation and direct the bound hIAPP for lysosomal degradation in macrophages. Further studies demonstrate that the enhanced hIAPP clearance has been through the endolysosomal system and depends on MGL1-mediated endocytosis. Intriguingly, Λ enantiomers show even better efficiency in preventing hIAPP aggregation and promoting internalization and degradation of hIAPP than Δ enantiomers. Moreover, metallohelix-based degraders also faciltate the clearance of hIAPP through asialoglycoprotein receptor in liver cells. Overall, our studies demonstrate that chiral metallohelix can be employed for targeted degradation of extracellular misfolded proteins and possess enantioselectivity.
Capability of THz for Thermo-transmittance/water content measurements of insulating materials: heat and mass transfer (2018)

THz waves show to be an effective mean for several applications such as security, non-destructive, water content monitoring for wood and food products. The increasing use of THz is due to the sufficient resolution for such applications, its low cost and the safe levels of radiation. This study consists of two parts. The first one represents the use of THz imaging technique for studying the transient thermal transfer within semi-transparent insulating materials. The second part will be dedicated to transient hydric transfer.
Development and Multisite Assessment of a Novel Shoulder Motion Joint Simulator (2021)

Multiple biomechanical shoulder simulators have been described in the literature, with a trend toward increasing complexity to better simulate clinical scenarios. Our objective was to develop an advanced, novel shoulder joint simulator and compare outcomes at two separate institutions, for a typical shoulder joint motion simulation. Identical shoulder simulators were developed & deployed at both institutions. Eight cadaveric upper extremities were tested by simulating actively controlled, arm elevation in the plane of the scapula for two sequential test conditions (intact and nondestructive simulated cuff-tear), each repeated for a total of five trials. Muscle forces and joint translations were recorded for both conditions. The intact condition was repeated following simulated cuff-tear to assess effect of testing order. Statistical analyses were aimed at assessing repeatability and reproducibility of results within specimens, between specimens, and between institutions. The highest average forces were observed for the middle deltoid (233N or 32.5% body weight (BW)), followed by infraspinatus (99.0N), and posterior deltoid (93.7N) muscles. Differentiation between test conditions was unhindered by variability between repeated trials. Data from testing repeated over time, and between the two institutions were not significantly different. The novel shoulder simulator produced repeatable results with low trial-to-trial variation and outcomes were comparable between the two institutions. The results demonstrated a consistent response in muscle forces and humeral translation for the simulated rotator cuff tear condition. Such advanced shoulder simulators could thus be used for evaluating and optimizing surgical interventions and implant strategies.
Infrared response of YBa sub 2 Cu sub 3 O sub 7-. delta. films to pulsed, broadband synchrotron radiation (1990)

We report studies of a thin high {Tc} film operating as a fast bolometric detector of infrared radiation. The film has a response of infrared radiation. The film has a response of several mV when exposed to a 1 W, 1 ns duration broadband infrared pulse. The decay after the pulse was about 4 ns. The temperature dependence of the response accurately tracked dR/dT. A thermal model, in which the film's temperature varies relative to the substrate, provides a good description of the response. We find no evidence for other (non-bolometric) response mechanisms for temperatures near or well below {Tc}. 13 refs., 4 figs.
Prevention of Experimental Peritoneal Adhesions by Dextran (1964)

The development of postoperative adhesions following abdominal surgery is not completely understood. Factors governing individual response leading to extensive adhesions in some patients and their absence in others remain unexplained. Most reports directly relate the formation of adhesions to the amount of trauma inflicted during operative handling and manipulation of tissues.<sup>1</sup>Many experimental methods have been studied in an attempt to decrease postoperative adhesions because of their importance as a cause of intestinal obstruction. Recently, Knightly et al<sup>2</sup>and Spagna and Peskin<sup>3</sup>reported on the use of fibrinolysin to prevent adhesions in rats. The dose of fibrinolysin necessary to eliminate all adhesions was lethal in some animals. Investigation of less noxious substances seems justified. Dextran has been used successfully to prevent thrombosis of small arteries and large veins following trauma to the intima.<sup>4,5</sup>The mechanism by which dextran prevents thrombosis remains obscure. The total plasma volume
Shedding Light on Vacancy-Doped Copper Chalcogenides: Shape-Controlled Synthesis, Optical Properties, and Modeling of Copper Telluride Nanocrystals with Near-Infrared Plasmon Resonances (2013)

Size- and shape-controlled synthesis of copper chalcogenide nanocrystals (NCs) is of paramount importance for a careful engineering and understanding of their optoelectronic properties and, thus, for their exploitation in energy- and plasmonic-related applications. From the copper chalcogenide family copper telluride NCs have remained fairly unexplored as a result of a poor size-, shape-, and monodispersity control that is achieved via one-step syntheses approaches. Here we show that copper telluride (namely Cu(2-x)Te) NCs with well-defined morphologies (spheres, rods, tetrapods) can be prepared via cation exchange of preformed CdTe NCs while retaining their original shape. The resulting copper telluride NCs are characterized by pronounced plasmon bands in the near-infrared (NIR), in analogy to other copper-deficient chalcogenides (Cu(2-x)S, Cu(2-x)Se). We demonstrate that the extinction spectra of the as-prepared NCs are in agreement with theoretical calculations based on the discrete dipole approximation and an empirical dielectric function for Cu(2-x)Te. Additionally we show that the Drude model does not appropriately describe the complete set of Cu(2-x)Te NCs with different shapes. In particular, the low-intensity longitudinal plasmon bands for nanorods and tetrapods are better described by a modified Drude model with an increased damping in the long-wavelength interval. Importantly, a Lorentz model of localized quantum oscillators describes reasonably well all three morphologies, suggesting that holes in the valence band of Cu(2-x)Te cannot be described as fully free particles and that the effects of localization of holes are important. A similar behavior for Cu2-xS and Cu(2-x)Se NCs suggests that the effect of localization of holes can be a common property for the whole class of copper chalcogenide NCs. Taken altogether, our results represent a simple route toward copper telluride nanocrystals with well-defined shapes and optical properties and extend the understanding on vacancy-doped copper chalcogenide NCs with NIR optical resonances.
ChemInform Abstract: Synthesis of 9β‐Methyl‐2‐alkyl‐7‐oxo‐5‐arylmorphans. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
QTL mapping in rice (1995)

In the past 10 years, interest in applying the tools of molecular genetics to the problem of increasing world rice production has resulted in the generation of two highly saturated, molecular linkage maps of rice, and the localization of numerous genes and quantitative trait loci (QTLs). Primary studies have identified QTLs associated with disease resistance, abiotic stress tolerance and yield potential of rice in a range of ecosystems. The ability to identify, manipulate and potentially clone individual genes involved in quantitatively inherited characters, combined with the demonstrated conservation of numerous linkage blocks among members of the grass family, emphasizes the contribution of map-based genetic analyses both to applied and to basic crop research.
Implementation of parallel LFSR-based applications on an adaptive DSP featuring a pipelined configurable Gate Array (2008)

Linear feedback shift registers (LFSRs) are common structures in many application fields, including cryptography, digital broadcasting and communication. High-throughput requirements need highly parallel implementations, usually accomplished in state of the art system on chips (SoCs) with application specific coprocessors. Although this approach achieves the required performance, it rapidly shows lack of flexibility when those devices are proposed, as an example, for multi-standard modems or for security applications in which run-time update can provide added value. This paper shows the implementation of parallel LFSR-based applications on an embedded adaptive DSP featuring a Pipelined Configurable Gate Array (PiCoGA). With respect to standard embedded FPGAs, pipelined devices usually provide better performance, e.g. in terms of speed, but they commonly show the undeniable drawback of additional design constraints. As a test-case, we consider the implementation of the 32-bit CRC used in the Ethernet standard that achieves on the target architecture up to ~25Gbit/sec throughput, with a parallel LFSR processing 128 bit at time, which is comparable to the performance offered by some ASIC devices.
Publisher Correction: Anderson light localization in biological nanostructures of native silk (2018)

The original PDF version of this Article contained errors in Equations 1 and 2. Both equations omitted all Γ terms. This has been corrected in the PDF version of the Article. The HTML version was correct from the time of publication.
Sex-Based Differences in Athletes Undergoing Primary Hip Arthroscopy With Labral Reconstruction: A Propensity-Matched Analysis With Minimum 2-Year Follow-up (2022)

Despite different clinical characteristics and surgical procedures, both female and male athletes undergoing primary hip arthroscopy with labral reconstruction had significant improvements in all PROs at the minimum 2-year follow-up, high RTS rates, and similar rates of achieving the minimal clinically important difference and patient acceptable symptom state.
Non-thermal plasma techniques for abatement of volatile organic compounds and nitrogen oxides (1995)

Non-thermal plasma processing is an emerging technology for the abatement of volatile organic compounds (VOCs) and nitrogen oxides (NO{sub x}) in atmospheric-pressure air streams. Either electrical discharge or electron beam methods can produce these plasmas. Each of these methods can be implemented in many ways. There are many types of electrical discharge reactors, the variants depending on the electrode configuration and electrical power supply (pulsed, AC or DC). Two of the more extensively investigated types of discharge reactors are based on the pulsed corona and dielectric-barrier discharge. Recently, compact low-energy (<200 keV) electron accelerators have been developed to meet the requirements of industrial applications such as crosslinking of polymer materials, curing of solvent-free coatings, and drying of printing inks. Special materials have also been developed to make the window thin and rugged. Some of these compact electron beam sources are already commercially available and could be utilized for many pollution control applications. In this paper we will present a comparative assessment of various nonthermal plasma reactors. The thrust of our work has been two-fold: (1) to understand the scalability of various non-thermal plasma reactors by focusing on the energy efficiency of the electron and chemical kinetics, and (2) to identify the byproducts to ensure that the effluent gases from the processor are either benign or much easier and less expensive to dispose of compared to the original pollutants. We will present experimental results using a compact electron beam reactor and various types of electrical discharge reactors. We have used these reactors to study the removal of NO{sub x} and a wide variety of VOCS. We have studied the effects of background gas composition and gas temperature on the decomposition chemistry.
Maximally random jammed packings of Platonic solids: Hyperuniform long-range correlations and isostaticity (2011)

We generate maximally random jammed (MRJ) packings of the four nontiling Platonic solids (tetrahedra, octahedra, dodecahedra, and icosahedra) using the adaptive-shrinking-cell method [S. Torquato and Y. Jiao, Phys. Rev. E 80, 041104 (2009)]. Such packings can be viewed as prototypical glasses in that they are maximally disordered while simultaneously being mechanically rigid. The MRJ packing fractions for tetrahedra, octahedra, dodecahedra, and icosahedra are, respectively, 0.763±0.005, 0.697±0.005, 0.716±0.002, and 0.707±0.002. We find that as the number of facets of the particles increases, the translational order in the packings increases while the orientational order decreases. Moreover, we show that the MRJ packings are hyperuniform (i.e., their infinite-wavelength local-number-density fluctuations vanish) and possess quasi-long-range pair correlations that decay asymptotically with scaling r(-4). This provides further evidence that hyperuniform quasi-long-range correlations are a universal feature of MRJ packings of frictionless particles of general shape. However, unlike MRJ packings of ellipsoids, superballs, and superellipsoids, which are hypostatic, MRJ packings of the nontiling Platonic solids are isostatic. We provide a rationale for the organizing principle that the MRJ packing fractions for nonspherical particles with sufficiently small asphericities exceed the corresponding value for spheres (∼0.64). We also discuss how the shape and symmetry of a polyhedron particle affects its MRJ packing fraction.
POSITIVE REGULATION IN A EUKARYOTE, A STUDY OF THE uaY GENE OF ASPERGILLUS NIDULANS: I. CHARACTERIZATION OF ALLELES, DOMINANCE AND COMPLEMENTATION STUDIES, AND A FINE STRUCTURE MAP OF THE uaY - oxpA CLUSTER (1982)

In this paper we characterize genetically a positive eukaryotic regulatory gene: the uaY gene of the ascomycete Aspergillus nidulans. Several steps in the uptake and degradation of purines are under the control of the uaY gene (summarized in Scazzocchio and Gorton 1977). In the present paper 12 uaY-mutations are characterized with respect to their inducibility for adenine deaminase, xanthine dehydrogenase (purine hydroxylase I) and urate oxidase and by the absence of the uric acid-xanthine permease scored in vivo by resistance to 2-thiouric acid. While 10 mutations are uniformly unleaky, two others are almost wild type for the induction of urate oxidase. A fine structure map of the uaY gene shows that the two "leaky" mutations are not clustered. The fine structure mapping unambiguously positions six uaY alleles and provides preliminary but interesting trends regarding the pattern of gene conversion in the uaY gene. The enzyme levels in all uaY-/uaY+ heterozygous diploids are intermediate between the corresponding uaY-/uaY- and uaY+/uaY+ homozygous diploids, suggesting that one functional copy of the uaY gene is able to mediate the complete induction of only one set of structural genes. No complementation was found between any two uaY- alleles. This establishes that the mutations showing either of the phenotypes are alleles in the same gene; it fails to provide evidence for intracistronic complementation. A mutation, oxpA5, causes resistance to the xanthine analogue oxypurinol (4,6-dihydroxypyrazolo-(3, 4-d)-pyrimidine) and partial constitutivity of adenine deaminase, xanthine dehydrogenase (purine hydroxylase I) and urate oxidase. The constitutive phenotype is suppressed by mutations, blocking the synthesis of intracellular inducers. The mutation is recessive and complements fully with the 11 uaY- mutations tested. It maps to the left of all 12 uaY mutations to which it has been crossed. The data indicate that both the resistance and constitutivity arise from one mutational event in a gene, oxpA, different from uaY and possibly adjacent to it. We propose that the oxpA gene codes for a protein involved in limiting the flow of inducers into the cell nucleus. Thus oxpA and uaY constitute a regulatory gene cluster, indicating that uaY is the regulatory gene.
OR Practice—An Efficient Decision Support System for Academic Course Scheduling (1989)

This paper describes a network-based decision support system approach to the most general form of the academic course scheduling problem. The dimensions of faculty, subject, time, and room are considered by incorporating a penalty function into a network optimization approach. The approach, based on a network algorithm, is capable of solving very large problems. This methodology can be applied to other scheduling situations where there are competing objectives and multiple resources. Such situations include: scheduling of exams, times, and rooms in an academic setting, and scheduling of clients, times, and facilities for physicians, hospitals, dentists, counselors, and clinics. Common problems in such settings include the utilization of available space, and dissatisfaction with assigned times and locations. The proposed system results in more effective room utilization patterns, improved instructor satisfaction levels, and streamlines the tedious scheduling process. We describe the use of the model to schedule all graduate and undergraduate courses in the College of Business Administration at Texas A&amp;M University. This involves 175 faculty, over 300 sections, 20 rooms, and 16 time slots for each semester's scheduling problem.
Reactive multilayer foils and their applications in joining (2007)

In this study, Ni/Al multilayer foils were fabricated by a cold rolling method. A two-stage reaction process was observed in the reaction-ignition experiment. The phase formation process in the cold rolled foils was studied. The first reaction stage with a slow reaction velocity was the lateral growth of Al3Ni phase at isolated nucleation sites and the subsequent coalescence into a continuous layer. The second reaction stage with a fast reaction velocity was the growth of the Al3Ni layers in the direction normal to the Ni/Al interface until all Al was consumed. Afterwards, Al3Ni reacted with the remaining Ni to form the final reaction product, AlNi. The reaction velocities of the first reaction stage for the cold rolled foils were around 7 mm/s. Ti/Al multilayer foils were also fabricated by cold rolling to test whether this method can be extended to fabricate other metal/aluminum multilayer systems. The entire reaction process for the cold rolled Ti/Al multilayer foils was identified, which was similar to the cold rolled Ni/Al multilayer foils. Reactive multilayer foils can be used as local heat sources to melt solder or braze layers and thus bond different components. Silicon wafers were bonded using reactive Ni/Al multilayer foils. A numerical model was developed to predict the temperature evolution during the bonding process. The simulation result showed both localized heating and rapid cooling during reactive foils joining process. Based on our experimental observation, the bonding strength of the reactive bond was estimated to be larger than the failure strength of bulk silicon. Moreover, leakage test in isopropanol alcohol (IPA) showed that reactive foils bonds possessed good hermeticity for liquid.
Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds (2004)

The paper describes the preparation and characterisation of porous calcium carbonate microparticles with an average size of 5 µm and their use for encapsulation of biomacromolecules. The average pore size of about 30–50 nm enables size selective and time-dependent permeation of different macromolecules. Layer-by-layer adsorption of polyelectrolytes into these particles followed by core dissolution leads to formation of interconnecting networks (matrix-like structure) made of polyelectrolyte complexes. The structure can be used for accumulation of bio-macromolecules, mainly proteins. Besides the inter-polyelectrolyte structure templated on porous CaCO3 microparticles the microgel particles (“ghost”) can also be made inside by complexing alginate and calcium. The adsorption of biomacromolecules inside the porous calcium carbonate particles is presumably regulated by electrostatic interactions on the microparticle surface within pores and protein–protein interactions. Protein adsorption into CaCO3 microparticle voids together with layer-by-layer assembly of biopolymers provide a way for fabrication of completely biocompatible microcapsules envisaging their use as biomaterials.
Systemic therapy for bladder cancer – a medical oncologist’s perspective (2014)

Advanced bladder cancer, both muscle-invasive localized disease and metastatic disease, is managed with systemic chemotherapy. Cisplatin-based multi-agent chemotherapy remains the cornerstone for systemic therapy. MVAC (methotrexate-vinblastine-doxorubicin-cisplatin) has been most rigorously studied, both neoadjuvantly and for palliation of metastatic disease. For metastatic disease, cisplatin-gemcitabine (GC) has compared favorably to MVAC due to improved tolerability with similar efficacy. GC has been adopted as standard therapy. Neoadjuvant chemotherapy for muscle-invasive bladder cancer improves survival among those patients eligible to receive cisplatin. Adjuvant chemotherapy is difficult to administer effectively given morbidity of radical cystectomy, and studies have shown mixed results about its benefit. Non-cisplatin regimens have been investigated but remain experimental and reserved for those not candidates for cisplatin in the metastatic setting. While multiple agents have been studied after metastatic disease progression after cisplatin-based therapy, there remain no FDA-approved therapies for the second line. Future trials with anti-VEGF therapy and immunotherapy are actively being investigated. This review examines the systemic therapy available to oncologists with current evidence and future directions.