gebhart/patrepeval huggingface dataset:
A transcriptional regulatory element in the coding sequence of the human Bcl‐2 gene (2004)

We investigated the protein-binding sites in a DNAse I hypersensitive site associated with bcl-2 gene expression in human B cells. We mapped this hypersensitive site to the coding sequence of exon 2 of the bcl-2 gene in the bcl-2-expressing REH B-cell line. Electrophoretic mobility shift assays (EMSAs) with extracts from REH cells revealed three previously unrecognized B-Myb-binding sites in this sequence. The protein was identified as B-Myb by using a specific antibody and EMSAs. Accordingly, the levels of B-Myb and bcl-2 proteins, and of Myb EMSA activity, were correlated over a wide range of cell lines, representing different stages of B-cell development. Transfection of REH cells with antisense B-myb down-regulated EMSA activity and the level of bcl-2, and led to the apoptosis of REH cells. Transfection of the bcl-2-non-expressing RPMI 8226 cell line with a B-Myb expression vector induced B-Myb EMSA activity and the expression of bcl-2. Reporter assays indicated that the HSS8 sequence containing the three B-Myb sites may act as an enhancer when it is linked to the bcl-2 gene promoter. Interaction of B-Myb with HSS8 may enhance bcl-2 gene expression by co-operating with positive regulatory elements (e.g. previously identified B-Myb response elements) or silencing negative response elements in the bcl-2 gene promoter.
Social network properties and self-rated health in later life: comparisons from the Korean social life, health, and aging project and the national social life, health and aging project (2014)

This paper has two objectives. Firstly, it provides an overview of the social network module, data collection procedures, and measurement of ego-centric and complete-network properties in the Korean Social Life, Health, and Aging Project (KSHAP). Secondly, it directly compares the KSHAP structure and results to the ego-centric network structure and results of the National Social Life, Health, and Aging Project (NSHAP), which conducted in-home interviews with 3,005 persons 57 to 85 years of age in the United States. The structure of the complete social network of 814 KSHAP respondents living in Township K was measured and examined at two levels of networks. Ego-centric network properties include network size, composition, volume of contact with network members, density, and bridging potential. Complete-network properties are degree centrality, closeness centrality, betweenness centrality, and brokerage role. We found that KSHAP respondents with a smaller number of social network members were more likely to be older and tended to have poorer self-rated health. Compared to the NSHAP, the KSHAP respondents maintained a smaller network size with a greater network density among their members and lower bridging potential. Further analysis of the complete network properties of KSHAP respondents revealed that more brokerage roles inside the same neighborhood (Ri) were significantly associated with better self-rated health. Socially isolated respondents identified by network components had the worst self-rated health. The findings demonstrate the importance of social network analysis for the study of older adults’ health status in Korea. The study also highlights the importance of complete-network data and its ability to reveal mechanisms beyond ego-centric network data.
Calibration of Far West Technology (FWT-60) Radiochromic Dye Dosemeters (1993)

Abstract Radiochromatic dye dosimetry was used to measure kilogray doses absorbed by various liquid samples during gamma ray exposure in a spent nuclear fuel pool. The source of nuclear fuel was the Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory (INEL). Calibrations were performed using a 60Co source and were run on bare dosemeters, as well as on dosemeters which were mocked to simulate the samples. These dosemeters were prepared as a dye-impregnated nylon film and are commercially available. When exposed to gamma ray doses of 0.5 to 200 kGy, a colour change occurs which has an optical density proportional to absorbed dose. The difference in the calibration curves demonstrates the importance of irradiation of dosemeters under conditions as close to the actual samples as possible. Since these dosemeters could not be immersed directly in the organic solutions of interest, they were sandwiched between layers of Lucite and stainless steel. This simulated the conditions inside an irradiated sample and provides a practical method of measuring absorbed doses. The reproducibility of measurements using the radiochromic dye dosemeters is also shown.
Studies in IVth group organometallic chemistry. IX: Synthesis of organosilicon compounds and polymers containing the p‐Phenylene Group (1962)

Abstract A number of oligomeric p ‐phenylenesilanes containing 2‐6 silicon atoms per molecule and a series of low molecular weight poly‐ p ‐phenylenesilanes (n = 10‐30) have been prepared by Wurtz‐type condensation reactions involving appropriate combinations of p ‐chlorophenyl‐ and chloro‐silanes. The polymeric products have been characterized by infrared spectroscopy, analytical and thermogravimetric data, and number‐average molecular weights, the low value of which is presumably caused by participation of the solvent (toluene) in the reaction. The polymers started to lose weight at temperatures varying from 310 to 485°.
THE EFFECT OF RUTHENIUM RED, A Ca++ CHANNEL BLOCKER, ON A RED PIGMENT FORMATION IN MECHANICALLY WOUNDED SCALES OF Hippeastrum x hybr. hort., AND ON THE GROWTH AND DEVELOPMENT OF Phoma narcissi (2006)

Mechanical wounding of Hippeastrum bulb scales and other organs induces red colouration. It was found that ruthenium red (RR), a Ca ++ channel blocker, at concentrations 0.1, 0.2 and 0.5 mM substantially inhibited the red pigment formation in wounded scales of Hippeastrum, proportionally to the concentration used. RR, at concentration of 0.3 mM, totally inhibited the mycelium growth of Phoma narcissi, a pathogen of Hippeastrum, on PDA medium. However, RR did not inhibit development of the disease symptoms caused by P. narcissi on scales and basal plate of Hippeastrum bulbs. It is suggested that blockage of Ca ++ influx by ruthenium red inhibits jasmonate biosynthesis and signalling pathway mediating the red pigment biosynthesis and accumulation.
Colostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytes (1999)

Passive immunisation, based on bovine colostral preparations, is an area of active research. Specific bovine antibodies inhibit the virulence factors of target pathogens but the interactions between whey preparations and human immune defence cells are not well known. Bovine colostrum inhibits the phagocytic activity of bovine leucocytes and this may reflect the biological activity of immunoglobulins in it. Therefore, this study aimed to examine the effects of bovine whey protein preparations from the colostrum of Streptococcus mutans/S. sobrinus-immunised and sham-immunised cows on binding, ingestion and killing of these bacteria by human leucocytes. Binding and ingestion of FITC-labelled bacteria were estimated by flow cytometry and leukocyte activation was measured as chemiluminescence. Killing rate was estimated by plate counting and by measuring bioluminescence from S. mutans- containing the insect luciferase gene. Colostral whey protein preparation from hyperimmunised cows activated human leucocytes by opsonising specific bacteria. Neutrophils, eosinophils and monocytes weakly phagocytosed non-opsonised bacteria and bacteria opsonised with control product. On the contrary, binding and ingestion were efficient in the presence of the preparation from immunised cows. Thus, these results show that bovine colostral whey proteins are able to support the activation of human phagocytes against pathogenic microbes and that this property is related to specific antibodies in whey preparations. These whey proteins may also be clinically useful, especially in preventing the colonisation of newly erupted teeth by mutans streptococci.
Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension (2019)

NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the respiratory chain Complex II and decreased levels of lipoic-acid-dependent enzymes, and develop pulmonary arterial hypertension (PAH) in ∼70% of cases. We investigated whether rats with a human mutation in NFU1 are also predisposed to PAH development. A point mutation in rat NFU1<sup>G206C</sup> (human G208C) was introduced through CRISPR/Cas9 genome editing. Hemodynamic data, tissue samples, and fresh mitochondria were collected and analyzed. NFU1<sup>G206C</sup> rats showed increased right ventricular pressure, right ventricular hypertrophy, and high levels of pulmonary artery remodeling. Computed tomography and angiography of the pulmonary vasculature indicated severe angioobliterative changes in NFU1<sup>G206C</sup> rats. Importantly, the penetrance of the PAH phenotype was found to be more prevalent in females than in males, replicating the established sex difference among patients with PAH. Male and female homozygote rats exhibited decreased expression and activity of mitochondrial Complex II, and markedly decreased pyruvate dehydrogenase activity and lipoate binding. The limited development of PAH in males correlated with the preserved levels of oligomeric NFU1, increased expression of ISCU (an alternative branch of the iron-sulfur assembly system), and increased complex IV activity. Thus, the male sex has additional plasticity to overcome the iron-sulfur cluster deficiency. Our work describes a novel, humanized rat model of NFU1 deficiency that showed mitochondrial dysfunction similar to that observed in patients and developed PAH with the same sex dimorphism.
Galvanic displacement of metals on semiconductor nanocrystals (2009)

We report the galvanic displacement (GD) of germanium from germanium nanocrystals (Ge-NCs) with silver. The Ge-NCs are synthesized by reductive thermal processing of germanium suboxide sol-gel prepolymers. Thermal processing yields size-controlled oxide-embedded Ge-NCs, which are liberated by dissolution of the germanium oxide matrix in water. Subsequent exposure of the freestanding Ge-NCs to aqueous solutions of AgNO3 leads to deposition of silver nanostructures by GD. The resulting metal structures were analyzed by XRD, XPS, TEM and EDX, confirming deposition of elemental silver in a variety of shapes and sizes.
Increase of Capsaicin‐Induced Trigeminal Fos‐Like Immunoreactivity by 5‐HT 7 Receptors (2011)

Data suggest that 5-HT(7) receptors increase activation of meningeal trigeminovascular afferents and/or transmission of nociceptive information in the brain stem. This mechanism could be relevant in migraine and its prophylactic treatment.
Optimization of ECF bleaching and refining of kraft pulping from olive tree pruning (2012)

The aim of the present work was to find an optimum kraft pulping process for olive tree pruning (OTP) in order to produce a bleachable grade pulp of Kappa number about 17. The kraft pulp produced under optimized conditions showed a viscosity of 31.5 mPa.s and good physical, mechanical, and optical properties, which are acceptable for paper grade production. The strength and optical properties were measured on pulps unrefined and refined in a PFI mill with up to 2000 revolutions before and after bleaching. The OTP pulp was bleached to 90% ISO brightness (kappa &lt; 1); however the process demanded a long sequence of stages, OD(EP)D(EP)D, and a higher than usual total chemical dosage (24.78 kg/odt pulp). Overall, OTP is suggested as an interesting raw material for cellulosic pulp production because its properties are comparable to those of other agricultural residues currently used in the paper industry.
Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis (2021)

Gut and systemic microbiota/immune homeostasis are perturbed in MS. Our results argue that defective IgA responses in MS are linked to a breakdown of systemic tolerance to gut microbiota leading to an enhanced triggering of systemic IgG immunity against gut commensals occurring early in MS.
INTERFERENCE BY SERUM PROTEINS WITH LH RADIOIMMUNOASSAY USING IMMUNOSORBENT (1973)

ABSTRACT The percentage of LH* bound to antibodies that have been covalently bound to cellulose is diminished in the presence of LH-free human serum and sera from various species of animals. Serum fractionation studies on Sephadex G 200 show that the greatest interference comes from the proteins eluted in the void volume i. e. the high molecular weight proteins. Specifically, the gamma M globulins and the α 2 -macroglobulins appear to play an important role, as demonstrated by tests in which these proteins were neutralized by gamma M and α 2 -macroglobulin antisera.
Site‐Specific Linking of Biomolecules via Glycan Residues Using Glycosyltransferases (2008)

The structural information on glycosyltransferases has revealed that the sugar-donor specificity of these enzymes can be broadened to include modified sugars with a chemical handle that can be utilized for conjugation chemistry. Substitution of Tyr289 to Leu in the catalytic pocket of bovine beta-1,4-galactosyltransferase generates a novel glycosyltransferase that can transfer not only Gal but also GalNAc or a C2-modified galactose that has a chemical handle, from the corresponding UDP-derivatives, to the non-reducing end GlcNAc residue of a glycoconjugate. Similarly, the wild-type polypeptide-N-acetyl-galactosaminyltransferase, which naturally transfers GalNAc from UDP-GalNAc, can also transfer C2-modified galactose with a chemical handle from its UDP-derivative to the Ser/Thr residue of a polypeptide acceptor substrate that is tagged as a fusion peptide to a non-glycoprotein. The potential of wild-type and mutant glycosyltransferases to produce glycoconjugates carrying sugar moieties with chemical handle makes it possible to conjugate biomolecules with orthogonal reacting groups at specific sites. This methodology assists in the assembly of bio-nanoparticles that are useful for developing targeted drug-delivery systems and contrast agents for magnetic resonance imaging.
Multivariable Process Control: Decentralized, Decoupling, or Sparse? (2009)

In this article, a systematic approach is proposed to design PI-/PID-based multivariable control systems in which the designs and analyses of decentralized, decoupling, and sparse control schemes are all treated under a unified framework. First, based on the relative normalized gain array (RNGA), a best loop pairing is obtained using the RGA (relative gain array)−Nederlinski index (NI)−RNGA rules. The index matrix is then calculated, and the control structure is determined according to a selection criterion. Finally, the selected loop controllers are independently designed based on equivalent transfer functions. The effectiveness of the proposed design approach is verified by analysis of several multivariable industrial processes, demonstrating that the selected control structure results in better overall system performance.
Calcium and Strontium Thiosulfate, CaS2O3×6H2O and SrS2O3×5H2O. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Compact fiber laser approach to generating 589 nm laser guide stars (2005)

We are developing an all-fiber laser system for generating 589 nm light for laser-guided adaptive optics. If only natural stars can be used to measure the turbulence in the Earth's atmosphere, at most a few percent of the sky is accessible to adaptive optics correction. Laser guide stars are therefore crucial to the broad use of adaptive optics, because they facilitate access to a large fraction of possible locations on the sky. In particular, lasers tuned to the 589 nm resonance line of atomic sodium are able to create an artificial beacon at altitudes of 95-105 km, thus coming as close as possible to reproducing the light path of starlight. The deployment of multiconjugate adaptive optics on large aperture telescopes world-wide will require the use of three to five sodium laser guide stars in order to achieve uniform correction over the aperture with a high Strehl value. Current estimates place the minimum required laser power at 10 W per laser for a continuous wave source. In addition, the lasers need to be compact, efficient, robust and turnkey.
INFLUENCE OF AMPLIFIER AND FEEDBACK ON THE DYNAMICS OF A WATER HYDRAULIC SERVOVALVE (1999)

This paper deals with the influence of electronic elements, especially the saturation of servo-amplifier and the demodulator filter in the feedback loop of the servovalve. Nonlinear numerical analysis and linear approximation theory are applied to calculate the frequency responses and the wave forms of the system variables. The demodulator filter for LVDT results in an increase of gain and a decrease of a phase lag of spool motion. Thus, it can improve the system response under suitable combination of parameters. The saturation of servo-amplifier distorts wave forms of flapper and spool motion, and renders their frequency response worse.
Rank Detection Thresholds for Hankel or Toeplitz Data Matrices (2020)

In Principal Component Analysis (PCA), the dimension of the signal subspace is detected by counting the number of eigenvalues of a covariance matrix that are above a threshold. Random matrix theory provides accurate estimates for this threshold if the underlying data matrix has independent identically distributed columns. However, in time series analysis, the underlying data matrix has a Hankel or Toeplitz structure, and the columns are not independent. Using an empirical approach, we observe that the largest eigenvalue is fitted well by a Generalized Extreme Value (GEV) distribution, and we obtain accurate estimates for the thresholds to be used in a sequential rank detection test. In contrast to AIC or MDL, this provides a parameter that controls the probability of false alarm. Also a lower bound is presented for the rank detection rate of threshold-based detection for rank-1 problems.
Crystal structure of (2,6-diisopropyl-phenyl)-pyridin-2-yl-amine toluene hemisolvate, C17H22N2 · 0.5C7H8 (2007)

Article Crystal structure of (2,6-diisopropyl-phenyl)-pyridin-2-yl-amine toluene hemisolvate, C17H22N2 · 0.5C7H8 was published on September 1, 2007 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 222, issue 3).
Behavioural Modeling of Solid State Power Controllers (SSPC) for Distributed Power Systems (2009)

The development of new aircrafts, such as A380 and B787, has provided new opportunities in the field of electronic devices and power electronics. One of the most interesting areas is focused on the protection devices field and the management of the loads by means of the Solid State Power Controllers (SSPC). This fact is mainly due to the great increase of these devices in the architectures of the electrical power distribution systems used in the new airplanes. In this paper, the areas of interest for research groups regarding SSPC in onboard platforms are presented. Also, behavioural SSPC model has been developed according with different manufacturers datasheets. Moreover, experimental validation with commercial SSPC are presented.
Field and Lab Convergence in Poisson LUPI Games (2007)

In the lowest unique positive integer (LUPI) game, players pick positive integers and the&#13;\nplayer who chose the lowest unique number (not chosen by anyone else) wins a fixed&#13;\nprize. We derive theoretical equilibrium predictions, assuming fully rational players with&#13;\nPoisson-distributed uncertainty about the number of players. We also derive predictions&#13;\nfor boundedly rational players using quantal response equilibrium and a cognitive hierarchy of rationality steps with quantal responses. The theoretical predictions are tested&#13;\nusing both field data from a Swedish gambling company, and laboratory data from a&#13;\nscaled-down version of the field game. The field and lab data show similar patterns: in&#13;\nearly rounds, players choose very low and very high numbers too often, and avoid focal&#13;\n("round") numbers. However, there is some learning and a surprising degree of convergence toward equilibrium. The cognitive hierarchy model with quantal responses can&#13;\naccount for the basic discrepancies between the equilibrium prediction and the data.
Salvage High-intensity Focused Ultrasound for the Recurrent Prostate Cancer after Radiotherapy (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. Shoji, M. Nakano, T. Omata, Y. Harano, Y. Nagata, Y. Usui, T. Terachi, T. Uchida; Salvage High‐intensity Focused Ultrasound for the Recurrent Prostate Cancer after Radiotherapy. AIP Conf. Proc. 9 March 2010; 1215 (1): 234–238. https://doi.org/10.1063/1.3367149 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
GENE TRANSFER IN AMPHIBIAN EGGS AND OOCYTES (1981)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Inverse designed photonic crystal de-multiplex waveguide coupler (2005)

A two-dimensional photonic crystal diplexer integrated with a waveguide coupler is proposed. The design is computer generated through an inverse design process, limited within an area measuring 5 mumx5 mum. The best working device was designed for the optical communication wavelengths, 1.50 mum and 1.55 mum, i.e. a channel spacing of 50 nm. The device exhibits crosstalks suppressed below 40dB and coupling efficiencies close to 80%, for both channels.
Non-tuberculous mycobacterial pulmonary infections (2018)

University of Dundee. Hospital and Medical School. Scottish Centre for Respiratory Research. Dundee, United Kingdom.
Anomalous dispersion in photonic crystal fiber (2000)

We describe the measured group-velocity dispersion characteristics of several air-silica photonic crystal fibers with anomalous group-velocity dispersion at visible and near-infrared wavelengths. The values measured over a broad spectral range are compared to those predicted for an isolated strand of silica surrounded by air. We demonstrate a strictly single-mode fiber which has zero dispersion at a wavelength of 700 mm. These fibers are significant for the generation of solitons and supercontinua using ultrashort pulse sources.
Two-dimensional lock-in amplifier systems for microscopic imaging (2002)

We have previously developed two-dimensional lock-in amplifier systems that can detect very small changes in the light intensity distributions of images. In general, optical microscope systems have poor resolution in the depth direction rather than in the focal plane, and thus it is important to improve the depth resolution to achieve three-dimensional imaging with high-resolution. In this paper, we present a new technique to improve the depth resolution by implementing lock-in amplifier technology. In this technique, a lock-in amplifier system is used to obtain derivatives of the image intensity in the depth direction by using these derivatives, the depth resolution can be improved by a factor of 3.5. We believe that the systems should be applicable in the two-dimensional measurement of optical information.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Jester 2.0 (poster abstract) (1999)

No abstract available.