gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Diels—Alder Chemistry of 2‐Diethoxyphosphinylcyclohex‐2‐enones. A New Approach to Complex Phosphonates and Synthetic Applications of the β‐Keto Phosphonate System. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid Cells (1999)

The tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) is a member of the recently defined TRAF family. It takes part in the signal transduction of the TNF receptor 2 (TNFR2), the lymphotoxin-beta receptor (LT-betaR), CD40, CD30, and LMP1; is induced by LMP1 in vitro; and protects lymphoid cells from apoptosis. To identify the cells in which TRAF1 is active in vivo, we studied TRAF1 transcripts in normal lymphoid tissue, in Epstein-Barr virus (EBV)-induced lymphoproliferations, and in malignant lymphomas with special reference to those that overexpress the cytokine receptor CD30 and CD40 of the TNF receptor family at the single-cell level using a radioactive in situ hybridization. In normal lymphoid tissue, TRAF1 message proved to be absent from all resting B and T cells as well as from macrophages and accessory cells (follicular dendritic cells and interdigitating cells) and present in few perifollicular and intrafollicular lymphoid blasts. In contrast, there was a high and consistent TRAF1 overexpression in EBV-induced lymphoproliferations and Hodgkin's disease. Nearly all non-Hodgkin's lymphoma show low or no TRAF1 expression. Only some cases of diffuse large B-cell lymphoma showed a moderate to high TRAF1 signal. Several of the latter cases were EBV+. These data confirm that TRAF1 is an inducible molecule and indicates its deregulation in the mentioned disorders with the potential of a blockage of the apoptotic pathway.
Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis (2023)

Chronic viral liver infections continue to be a major public health problem. Single-cell characterisation of liver immune cells during hepatitis C and post-cure provides unique insights into the architecture of liver immunity contributing to the resolution of the first curable chronic viral infection of humans. Multiple layers of innate immune regulation during chronic infections and persistent immune modifications after cure are revealed. Researchers and clinicians may leverage these findings to develop methods to optimise the post-cure environment for HCV and develop novel therapeutic approaches for other chronic viral infections.
H2optimal control with an a-shifted pole constraint (1993)

Abstract Modified Lyapunov equations for regional pole constraints in H2 synthesis have been considered in recent papers. This approach involves a constraint equation for enforcing the pole constraints and leads to an auxiliary cost that overbounds the original H2 performance. The auxiliary cost can then be used for optimization with respect to the modified Lyapunov equations that characterize the constraint region. In this paper, we consider an α-shifted constraint region and show that an augmented system whose order is twice that of the original system can be constructed to eliminate the need for an overbound so that exact H2 cost optimization can be performed. This augmented system is then utilized for closed-loop controller synthesis within a decentralized static output feedback setting. The construction of the augmented system is a refinement of the approach of Gu et al. (1992). A numerical algorithm based upon the BFGS quasi-Newton method is used for computing the optimal controller gains. The numerical results are compared to the classical exponential cost weighting technique of Anderson and Moore (1989).
Overview of WiMAX system and related power amplifier design (2008)

Worldwide Interoperability for Microwave Access (WiMax) is an emerging standard for next generation wireless communication system with high data rate and broad coverage. It is based on the Orthogonal Frequency Division Multiplexing (OFDM) technology by taking advantage of ever increasing computing power in the DSP development. In this paper a brief overview of the WiMax technology will be provided. The focus of the discussion then will be on the special challenges in WiMax power amplifier design. Design examples will also be provided.
His84 rather than His35 is the active site histidine in the corrinoid protein MtrA of the energy conserving methyltransferase complex from Methanobacterium thermoautotrophicum (1998)

The energy conserving corrinoid containing MtrA-H complex from Methanobacterium thermoautotrophicum is composed of eight different subunits of which MtrA harbors the corrinoid prosthetic group, the corrinoid being bound in the base-off/His-on configuration. Based on sequence comparisons it was recently proposed that His35 of MtrA is the active site histidine. We report here that His84 rather than His35 is the axial ligand to the cobamide in MtrA.
OAM for Packet-Optical Integration in Segment Routing (2016)

This document describes a list of functional requirements for
transport segment OAM in Segment Routing (SR) based networks.
Development of Pharmacophore Model and Asymmetric Synthesis of Novel Tetrahydrofuran Derivatives Enroute to Triple Uptake Inhibitors As Anti-Depressant Agents (2014)

Unipolar depression, caused by an imbalance of monoamine neurotransmitters in brain, is ranked as the most prevalent of all somatic and psychiatric illness. It is estimated that about 40 % of patients remains refractory to treatment thereby limiting the use of current antidepressant drugs. Moreover, because of relapse and unwanted side effects of existing drugs there is an unmet need to discover novel agents for the treatment of this devastating mental disorder. Current treatment aims at alleviating extraneuronal concentration of serotonin (5-HT) and /or norepinephrine (NE) (Figure 1). Tricyclic antidepressants were among the first class to have been discovered but due to their nonspecific side effects they have limited use in clinics. They have been largely replaced by second-generation antidepressants including selective serotonin reuptake inhibitors (SSRI, e.g., fluoxetine, Figure 2), selective norepinephrine reuptake inhibitors (NRI, e.g. reboxetine, Figure 2), and serotonin and norepinephrine reuptake inhibitors (SNRI, venlafexine, Figure 2).
Advances and Prospects in Stem Cells for Cartilage Regeneration (2017)

The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. Based on the research into chondrocyte and stem cell technologies, this review discusses the damage and repair of cartilage and the clinical application of stem cells, with a view to increasing our systematic understanding of the application of stem cells in cartilage regeneration; additionally, several advanced strategies for cartilage repair are discussed.
Blue electrophosphorescent organoplatinum(ii) complexes with dianionic tetradentate bis(carbene) ligands (2011)

Robust charge-neutral Pt(II) complexes containing dianionic tetradentate bis(N-heterocyclic carbene) ligands exhibit intense blue phosphorescence in fluid solutions and in polymer films, and have been vacuum-deposited as a phosphorescent dopant in organic blue-light-emitting diodes.
Models for the identification and analysis of banking Risks (2016)

A basic property of the rating system is the ability to fit customers risk class to which they belong, namely good payer customers or bad payer clients. The tests establishing the classification methods have been applied beginning with the medical science, biology, engineers starting with 1950 and in the late 1990s they have been adapted to be models of application in the credit rating. Basel Committee (1999) identifies this model as a difficult one to develop quantitative models of credit.
Introduction to Radiobiology (1992)

(1992). Introduction to Radiobiology. International Journal of Radiation Biology: Vol. 62, No. 1, pp. 125-125.
Radioisotope Detection Device and Methods of Radioisotope Collection (2023)

A device for collection of radionuclides includes a mixture of a polymer, a fluorescent organic scintillator and a chemical extractant. A radionuclide detector system includes a collection device comprising a mixture of a polymer, a fluorescent agent and a selective ligand. The system includes at least one photomultiplier tube (PMT). A method of detecting radionuclides includes providing a collector device comprising a mixture comprising a polymer, a fluorescent organic scintillator and a chemical extractant. An aqueous environment is exposed to the device and radionuclides are collected from the environment. Radionuclides can be concentrated within the device.
Outcomes of head and neck squamous cell carcinomas (HNSCC) treated with reirradiation (RRT) at Mayo Clinic. (2015)

6064 Background: RRT is offered as definitive (DRRT) or post-operative (PRRT) treatment for patients (pts) with loco-regionally recurrent (LRR) or new primary (NP) HNSCC in previously irradiated volumes. We report the results of a retrospective chart review of all consecutive pts with LRR and NP HNSCC treated with DRRT and PRRT at Mayo Clinic. Methods: We included LRR and NP HNSCC pts treated with DRRT/PRRT from 2003-2011 at all Mayo Clinic campuses. Patient and treatment related data were collected. Loco-regional recurrence rate (LR) and distant metastases rate (DM) at 2 years, and overall survival (OS) from end of RRT using Kaplan-Meier methods, were calculated. Results: We identified 89 pts (68 M, 21 F). 67 pts had LRR; 22 NP. Treatment included salvage surgery with PRRT (47 pts) and DRRT (42 pts). 30 pts received concurrent chemotherapy (CT) with PRRT; 33 DRRT pts received CT. Median prior RT dose was 66 Gy (26.4 – 79.2 Gy). Median PRRT dose was 60 Gy (11 – 70 Gy). Median DRRT dose was 69.6 Gy (18 – 76.8 Gy). LR occurred in 42 pts (47%) after RRT; 35 pts (39%) had LR by 2 years (95% CI, 30 – 50%). DM occurred in 20 pts (22%) after RRT; 16 pts (18%) had DM by 2 years (95% CI, 11 – 27%). Median OS was 22.2 mos (95% CI, 17.0 – 29.8 mos), with 2- and 5-year OS 47% and 16%. No difference in OS between LRR- and NP-HNSCC or PRRT and DRRT was found. CT was associated with shorter time to LR (4.3 vs. 12.1 mos, p = 0.008), but not with time to distant metastases or OS. At last follow-up (median 78.1 mos) 21 pts (24%) were alive, with 43.3 mos (95% CI, 27.6 – 52.9 mos) median OS from time of LRR/NP. Among surviving pts, 2 cases of osteoradionecrosis (10%) and 1 carotid artery pseudoaneurysm with sentinel bleed (5%) were reported, with no reported spinal cord injuries. OS was better among 70 pts treated to at least 60 Gy (n = 70) vs. pts treated with less than 60 Gy (median OS 25.2 mos, 95% CI, 19.4 – 32.0 mos; vs. median OS 9.5 mos, 95% CI, 6.8 – 28.7 mos; p = 0.06). Conclusions: RRT cures a small number of pts. 2-year OS of LRR/NP HNSCC pts treated with RRT in the time frame of this study appears superior to published outcomes. Shorter time to LR among pts receiving CT warrants further study, but may signify selection bias toward more aggressive therapy for pts with high risk LRR/NP HNSCC.
Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer (2016)

Overexpression of CD44v6 was a significant predictor of lymph node metastasis in early gastric cancer. The prediction nomograms incorporating CD44v6 can be useful to determine treatment plans in patients with early gastric cancer.
Glucocorticoid-induced Leucine Zipper (GILZ) and Long GILZ Inhibit Myogenic Differentiation and Mediate Anti-myogenic Effects of Glucocorticoids (2010)

Myogenesis is a process whereby myoblasts differentiate and fuse into multinucleated myotubes, the precursors of myofibers. Various signals and factors modulate this process, and glucocorticoids (GCs) are important regulators of skeletal muscle metabolism. We show that glucocorticoid-induced leucine zipper (GILZ), a GC-induced gene, and the newly identified isoform long GILZ (L-GILZ) are expressed in skeletal muscle tissue and in C2C12 myoblasts where GILZ/L-GILZ maximum expression occurs during the first few days in differentiation medium. Moreover, we observed that GC treatment of myoblasts, which increased GILZ/L-GILZ expression, resulted in reduced myotube formation, whereas GILZ and L-GILZ silencing dampened GC effects. Inhibition of differentiation caused by GILZ/L-GILZ overexpression correlated with inhibition of MyoD function and reduced expression of myogenin. Notably, results indicate that GILZ and L-GILZ bind and regulate MyoD/HDAC1 transcriptional activity, thus mediating the anti-myogenic effect of GCs.
The impact of training dataset size and ensemble inference strategies on head and neck auto-segmentation (2023)

Convolutional neural networks (CNNs) are increasingly being used to automate segmentation of organs-at-risk in radiotherapy. Since large sets of highly curated data are scarce, we investigated how much data is required to train accurate and robust head and neck auto-segmentation models. For this, an established 3D CNN was trained from scratch with different sized datasets (25-1000 scans) to segment the brainstem, parotid glands and spinal cord in CTs. Additionally, we evaluated multiple ensemble techniques to improve the performance of these models. The segmentations improved with training set size up to 250 scans and the ensemble methods significantly improved performance for all organs. The impact of the ensemble methods was most notable in the smallest datasets, demonstrating their potential for use in cases where large training datasets are difficult to obtain.
Metal–Organic Framework Materials for Desulfurization by Adsorption (2012)

Current European regulations limit the sulfur content of gasoline to 10 ppmw. Such deep desulfurization levels can be achieved by catalytic hydrodesulfurization processes, but they are accompanied by excessive H2 consumption for unwanted side reactions, in particular, for the hydrogenation of olefins. Selective adsorption constitutes an attractive alternative to catalytic desulfurization. The main challenge is to find adsorbents able to remove the sulfur compounds with very high selectivity from a complex mixture of paraffins, naphthenes, olefins, and aromatic compounds. In the present contribution we present the screening of a large number of metal–organic frameworks (MOFs) for this purpose, using batch adsorption experiments. For the two most promising structures (HKUST-1 and CPO-27-Ni, two cus-MOFs, that is, with coordinatively unsaturated sites), the dynamic behavior, the impact of a model nitrogen-containing compound (pyridine) on the adsorption properties, as well as the regenerability were also evaluated by breakthrough experiments. The good results obtained in purification of our model feeds incited us to perform measurements with a real gasoline feed using batch measurements. The feasibility of adsorptive desulfurization of gasoline using MOFs is discussed on the basis of these results.
Tables S1-3 and Figures S1-S8 from A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels (2023)

&lt;p&gt;Contains 3 tables and 8 figures with legends.&lt;/p&gt;
Lewis Acid-Promoted Oxidative Addition of Thioimidates to Pd(0) (2002)

The isomeric S-methyldihydropyrrins 9-Z and 9-E exhibit markedly different behavior in Pd(0)-catalyzed cross-coupling reactions. Thioimidates 9-Z are readily converted to imines 10-Z employing Pd(0)/AlkZnI. Under identical conditions 9-E are inert. Oxidative addition to Pd(0) requires activation by Zn or other Lewis acids, which is sterically unfavorable with 9-E. Analogous results were obtained with the related thioimidates 11-E,Z as well as with methylthiopyridines 19alpha-gamma. In the case of both 11 and 19 oxidative addition to Pd(0) was greatly facilitated in the presence of BF(3) x Et(2)O. The importance of Lewis acid activation to Pd(0) oxidative addition in such substrates appears to be a general phenomenon not previously recognized.
Reactions of Vitamin E with Peroxides. II. Reaction of Benzoyl Peroxide with d-α-Tocopherol in Alcohols* (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Vitamin E with Peroxides. II. Reaction of Benzoyl Peroxide with d-α-Tocopherol in Alcohols*C. T. Goodhue and H. A. RisleyCite this: Biochemistry 1965, 4, 5, 854–858Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/bi00881a009https://doi.org/10.1021/bi00881a009research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laparoscopic Posterior Adrenalectomy (2000)

Although technically more demanding, LPA should be considered in patients with tumors less than 6 cm, bilateral tumors, or extensive previous abdominal surgery.
Subtype-Specific Analysis of the K65R Substitution in HIV-1 That Confers Hypersusceptibility to a Novel Nucleotide-Competing Reverse Transcriptase Inhibitor (2015)

Compound A is a novel nucleotide-competing HIV-1 reverse transcriptase (RT) inhibitor (NcRTI) that selects for a unique W153L substitution that confers hypersusceptibility to tenofovir, while the K65R substitution in RT confers resistance against tenofovir and enhances susceptibility to NcRTIs. Although the K65R substitution is more common in subtype C viruses, the impact of subtype variability on NcRTI susceptibility has not been studied. In the present study, we performed experiments with compound A by using purified recombinant RT enzymes and viruses of subtypes B and C and circulating recombinant form CRF_A/G. We confirmed the hypersusceptibility of K65R substitution-containing RTs to compound A for subtype C, CRF_A/G, and subtype B. Steady-state kinetic analysis showed that K65R RTs enhanced the susceptibility to compound A by increasing binding of the inhibitor to the nucleotide binding site of RT in a subtype-independent manner, without significantly discriminating against the natural nucleotide substrate. These data highlight the potential utility of NcRTIs, such as compound A, for treatment of infections with K65R substitution-containing viruses, regardless of HIV-1 subtype.
LABORATORY EVALUATION OF AN ELECTRO-PNEUMATIC SAMPLING METHOD FOR REAL-TIME SOIL SENSING (2006)

An automated electro-pneumatic soil sampling method based on pressurized air for real-time soil analysis wasdeveloped and tested under laboratory conditions. Pressurized air was applied for 36 ms across a 2.5 cm diameter cylinderto cut a sample from a soil column and convey the sample along a delivery pipe into a container. An electro-pneumaticregulator valve was used to regulate the air pressure at 550, 690, and 830 kPa (80, 100, and 120 psi) using an analog electricalsignal. A two-position solenoid valve controlled by a stand-alone microprocessor was used to control pulse duration.Laboratory tests were conducted to determine the effectiveness of positive high-pressure air as a cutting force for differentsoil conditions. The effects of air pressure level, soil moisture content, soil compaction, and soil type on the quantity of soilsample obtained were investigated. Moisture content and air pressure level were the most significant factors, whilecompaction was not significant (. = 0.05) in terms of mass of soil obtained. Laboratory test results proved that pressurizedair was effective in cutting and transporting a soil sample in a short time period (36 ms) for all different soils studied in thisexperiment. The electro-pneumatic method was also capable of obtaining a consistent amount of soil sample with a coefficientof variation of less than 20% for any individual treatments in the experimental design. The electro-pneumatic soil samplingmethod is a viable candidate as a soil sampling system for on-the-go soil analysis.
Simulating Cellulose Structure, Properties, Thermodynamics, Synthesis, and Deconstruction with Atomistic and Coarse-Grain Models (2012)

Cellulose is still a mysterious polymer in many ways: structure of microfibrils, thermodynamics of synthesis and degradation, and interactions with other plant cell wall components. Our aim is to uncover the details and mechanisms of cellulose digestion and synthesis. We report the details of the structure of cellulose 1-beta under several temperature conditions and report here the results of these studies and connections to experimental measurements and the measurement in-silico the free energy of decrystallization of several morphologies of cellulose. In spatially large modeling, we show the most recent work of mapping atomistic and coarse-grain models into tomographic images of cellulose and extreme coarse-grain modeling of interactions of large cellulase complexes with microfibrils. We discuss the difficulties of modeling cellulose and suggest future work both experimental and theoretical to increase our understanding of cellulose and our ability to use it as a raw material for fuels and materials.