gebhart/patrepeval huggingface dataset:
Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells (2017)

Growing evidence suggests that agonists of glucagon-like peptide (GLP-1) receptor exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration, and, recently, a pilot clinical trial of Liraglutide in Alzheimer's disease patients showed improvements in cerebral glucose consumption that signifies disease progression. However, the exact underlying mechanism of action remains unclear. Chronic endoplasmic reticulum (ER) stress has recently emerged as a mechanism for neuronal injury, rendering it a potent therapeutic target for acute and chronic neurodegenerative disorders. Here, we investigate the neuroprotective effects of Liraglutide along with the signalling network against prolong ER stress and autophagy impairments induced by the non-competitive inhibitor of sarco/ER Ca<sup>2+</sup>-ATPase, thapsigargin. We show that Liraglutide modulates the ER stress response and elicits ER proteostasis and autophagy machinery homeostasis in human SH-SY5Y neuroblastoma cell line. These effects correlate with resolution of hyper-activity of the antioxidant Nrf2 factor and restoration of the impaired cell viability and proliferation. Mechanistically, Liraglutide engages Akt and signal transducer and activator of transcription 3 (STAT3) signalling to favour adaptive responses and shift cell fate from apoptosis to survival under chronic stress conditions in SH-SY5Y cells.
Direct amplification of length polymorphisms (DALP), or how to get and characterize new genetic markers in many species (1998)

Direct amplification of length polymorphisms (DALP) uses an arbitrarily primed PCR (AP-PCR) to produce genomic fingerprints and to enable sequencing of DNA polymorphisms in virtually any species. Oligonucleotide pairs were designed to each produce a specific multi-banded pattern and all the fragments thus generated can be directly sequenced with the same two universal M13 sequencing primers. This strategy combines the advantages of a high resolution fingerprint technique and the possibility of characterizing the polymorphisms. The use of family members as templates in the multi-locus detection step allows a direct test of allele transmission, as well as early mapping of the markers or selection of loci associated with some traits or diseases. We used this method to detect micro-deletions/insertions and microsatellite DNA loci useful in population genetics studies, but it could be applied in many other fields of biology, such as genome mapping for definition of polymorphic sequence tagged sites, directly localized on a genetic map.
Konformationsstabilität und Lumineszenz chiraler Lanthanoid‐Tetraamid‐Komplexe mit N‐substituiertem 1,4,7,10‐Tetraazacyclododecan‐Liganden (1997)

Die enantiomerenreinen Europium‐ und Terbiumkomplexe des makrocyclischen Liganden 1 sind in Lösung konformationsstabil. Der kationische Terbiumkomplex zeigt eine intensive Emission von circular polarisiertem Licht, die seine Verwendung als Chiralitätssonde denkbar scheinen läßt. magnified image magnified image
Aerosol delivery of trail pheromone disrupts the foraging of the red imported fire ant, Solenopsis invicta (2012)

The feasibility of using aerosol for delivery of trail pheromone was demonstrated, but the need for high purity combined with the difficulty of commercial supply makes this technique impractical. However, the commercial production of Z,E-α-farnesene of high purity by industrial biotechnology or from (E)-nerolidol may be possible in future, which would facilitate further development of trail pheromone disruption of S. invicta.
Synthesis and reactions of heterocyclic dithiocarbamates. (1979)

(Alkylthio) thiocarbonylimino-1-methyl-1, 2-dihydropyridine derivatives (3a-e) were prepared by the reaction of 2-amino-1-methylpyridinium iodide (1a-c or d) with carbon disulfide in the presence of sodium hydride and subsequent methylation with dimethyl sulfate in good yields. Similarly, 1-methyl-4-(methylthio) thiocarbonyl-1, 4-dihydropyridine (3i), 1-methyl-2-(methylthio) thiocarbonyl-1, 2-dihydrothiazole (3g), and 1-methyl-2-(methylthio) thiocarbonyl-1, 2-dihydrobenzothiazole (3h) were synthesized by the reaction of the corresponding 2-imino- and 4-imino-N-methyl heterocyclic compounds with carbon disulfide. The reaction of 3a-e with dimethyl acetylenedicarboxylate afforded the 2- or 4-[1, 2-bis (methoxycarbonyl)-2-thioxoethylidene]-1, 2- or 1, 4-dihydropyridine derivatives (8a-d). The reaction of 3i with dimethyl acetylenedicarboxylate (2 mol) gave cyclobuta [b] azocine (9). The reaction of 3h with dimethyl acetylenedicarboxylate afforded 2, 3-dihydrobenzothiazole-2-spiro-2'-(2H-pyrrole) (10). 2-[N-bis (methylthio) methylene] amino-N-methylpyridinium and benzothiazolium iodide (11b, c), which were prepared by the methylation of 3a and h with methyl iodide, reacted with nucleophiles to yield the corresponding products substituted on one or two methylthio groups.
Ignition and Flame Stabilization in High Speed Flows. (1997)

Abstract : Reduced mechanisms for ignition of hydrogen by heated air were deduced for the high-temperature/low-pressure and the low-temperature/high-pressure regimes. The reduced mechanisms were subsequently applied to the physical situations of the supersonic mixing layer and the counterflow through numerical simulation and activation energy asymptotics. Various ignition criteria were derived, and the issues of thermal versus radical induced ignition, external versus internal heating in inducing ignition, and quasi-steady versus transient ignition, were explored.
In Vivo Biocompatibility and Analytical Performance of Intravascular Amperometric Oxygen Sensors Prepared with Improved Nitric Oxide-Releasing Silicone Rubber Coating (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionIn Vivo Biocompatibility and Analytical Performance of Intravascular Amperometric Oxygen Sensors Prepared with Improved Nitric Oxide-Releasing Silicone Rubber CoatingMegan C. Frost, Steven M. Rudich, Huiping Zhang, Martin A. Maraschio, and Mark E. MeyerhoffCite this: Anal. Chem. 2003, 75, 4, 1037Publication Date (Web):January 14, 2003Publication History Published online14 January 2003Published inissue 1 February 2003https://pubs.acs.org/doi/10.1021/ac0207628https://doi.org/10.1021/ac0207628correctionACS PublicationsCopyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views354Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (9 KB) Get e-Alertsclose Get e-Alerts
Interações macromoleculares na matriz extracelular. Uma abordagem bioquímica e filogenética (2018)

\n O estudo de macrointeraçães na matriz extracelular (ECM) foi abordado em três modelos; a interação colágeno/colagenase, a interação colágeno/fibronectina e finalmente, a evolução da família enzimática das metaloproteinases de matriz (MMP). As MMP se caracterizam por sua notável especificidade contra componentes da ECM. As colagenases intersticiais, os membros mais estudados, clivam os colágenos intersticiais em um único ponto da molécula produzindo dois fragmentos característicos. Usando a hipótese da hidropaticidade complementar, a qual estipula que peptídeos codificados por sequências nucleotídicas complementares podem interagir entre si, foi possível caracterizar a sequência SQNPVQP em colagenase de fibroblasto ou SSNPIQP em colagenase de neutrófilo como importantes na interação das respectivas enzimas com o colágeno nativo. O fato da fibronectina, outro componente da ECM, ligar-se no mesmo domínio do colágeno clivado pelas colagenases possibilitou a utilização da mesma abordagem acima (hidropaticidade complementar) no estudo da interação colágeno/fibronectina. Sendo assim, foi possível caracterizar a sequência TNEGVMY da fibronectina como importante na interação com o colágeno. Adjacente a este sítio na fibronectina, existe uma sequência (AAHEEIC) que é homóloga ao sítio de ligação ao zinco presente nas MMP. Isto originou a possibilidade de que zinco pudesse modular a interação colágeno/fibronectina. De fato, zinco aumentou especificamente a ligação entre colágeno e fibronectina. Finalmente, abordou-se alguns aspectos filogenéticos da família das MMP. Foi caracterizada uma relação filogenética entre o núcleo enzimático das MMP e o domínio correspondente tanto na protease de Serratia como na protease B de Erwinia chrysanthemi, membros da mesma família de metaloproteinases bacterianas. Sendo assim, a atividade catalítica das MMP pode ter sido herdada das metaloproteinases bacterianas, enquanto a especificidade ao substrato talvez se constitua em uma aquisição das MMP eucarióticas.\n
Computer graphics, interactive technologies and collaborative learning synergy supporting individuals' skills development (2006)

In this paper, we describe work carried out using the synergy of interactive technologies, computer graphics and collaborative learning to improve educators and students' knowledge of basic education by supporting interdisciplinary work.Through direct manipulating accessible Web standard languages such as Hyper Text Markup Language - HTML and Virtual Reality Modeling Language - VRML and their templates, we used interactive graphics techniques and tools, including learning theories and methodologies such as experiential learning as support for enhancing children's interest on studying and authoring content related to subjects such as Mathematics, Geography, Geometry, Languages and Arts.As a consequence of these human and technical interactions, including knowledge acquisition, we achieved an increase in individuals' traditional and digital literacy skills, social inclusion, and community collaborative work engagement inside and outside school environment. Further we found an improvement in curriculum development.
Vibration of a Cracked Cantilever Beam (1998)

A continuous cracked bar vibration model is developed for the lateral vibration of a cracked Euler-Bernoulli cantilevered beam with an edge crack. The Hu-Washizu-Barr variational formulation was used to develop the differential equation and the boundary conditions for the cracked beam as an one-dimensional continuum. The crack was modelled as a continuous flexibility using the displacement field in the vicinity of the crack found with fracture mechanics methods. The results of three independent evaluations of the lowest natural frequency of lateral vibrations of an aluminum cantilever beam with a single-edge crack are presented: the continuous cracked beam vibration model, the lumped crack model vibration analysis, and experimental results. Experimental results fall very close to the values predicted by the continuous crack formulation. Moreover, the continuous cracked beam theory agrees better with the experimental results than the lumped crack flexibility theory.
Potential design and transport property of 0.1-μm MOSFET with asymmetric channel profile (1997)

This paper describes potential design and transport property of a 0.1-/spl mu/m n-MOSFET with asymmetric channel profile, which is formed by the tilt-angle ion-implantation after gate electrode formation. The relation between device performance and transport property of the asymmetric 0.1-/spl mu/m device is explored by Monte Carlo simulations, and measured electrical characteristics. The self-consistent Monte Carlo device simulation coupled with a process simulator reveals higher electron velocity at the source end of the channel and velocity overshoot at the source side of the channel, and the smaller high-energy tail of the distribution in the drain. This transport property creates high drain current, large transconductance, and low substrate current of the 0.1-/spl mu/m n-MOSFET with asymmetric channel profile.
Meta-Analysis of the Test–Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response (2022)

On the basis of these results, recommendations regarding SUV measurements for assessing minimal detectable changes based on repeatability and reproducibility are proposed. These should be applied to differentiate between response categories for a future set of FDG-PET-based criteria that assess clinically significant changes in tumor response.
Bubble swarm acoustics: Insertion loss of a layer on a plate (1980)

The farfield pressure radiated by a force-excited, extensive plate, separated from an ambient liquid by an air bubble swarm, is expressed in closed form in terms of bubble swarm and plate parameters, frequency, and the spherical angle ϑ from the normal to the plate. Comparing the pressure field with that of the plate in the absence of the bubble swarm, a ϑ-dependent insertion loss is computed. The wavenumber and impedance of the bubble swarm being highly dispersive, simple asymptotic expressions giving the insertion loss are formulated for various frequency ranges.
Analog Signal Processing: A Possible Alternative or Complement to Dominantly Digital Radio Schemes (2013)

Today's exploding demand for faster, more reliable, and ubiquitous radio systems in communication, instrumentation, radar, and sensors poses unprecedented challenges in microwave and millimeter-wave engineering. Recently, the predominant trend has been to place an increasing emphasis on digital signal processing (DSP). However, while offering device compactness and processing flexibility, DSP suffers fundamental drawbacks, such as high-cost analog-digital conversion, high power consumption, and poor performance at high frequencies.
Precision acoustic geodetic measurement of seafloor motion over 10 km (1996)

The technique deploys three or more precision transponders (PXP) on the seafloor, collects simultaneous round-trip travel times (±5 μs) from a hydrophone towed uniformly around the network above the seafloor (300 m), and measures the sound velocity (±10 ppm) and the relative depth of the hydrophone (±10 cm). These observations, modeled as ray traces through a spherical ocean model and ellipsoidal geodesic ray distances, are inverted to determine simultaneously, the centimeter level position of the transponders and towed hydrophone locations. Three PXPs were deployed on the Pacific and three on the Juan de Fuca plate to determine the pattern of deformation around the Juan de Fuca Ridge. Measurements were collected in 1994, 1995, and planned for 1996. Since 1991, at least four PXPs have been maintained seaward of the Cascadia Subduction Zone to measure the subduction rate using the Global Positioning System. No measurable relative horizontal motion among these PXPs is expected providing a test of system repeatabilities. Measurements were collected in 1991, 1993, 1994, 1995, and planned for 1996. This paper discusses the instrumentation, operations, measurement precision, modeling requirements, and current results. [Work supported by NSF.]
Low-energy electron-energy-loss spectroscopy of amorphous ice: Electronic excitations (1991)

We report high-resolution electron-energy-loss spectra at 14.3 and 19 eV incident electron energy for electronic excitations in multilayer films of amorphous ice. The lowest electronic transition has its threshold at 7.3 eV and its maximum at 8.5 eV. It is followed by a broad shoulder around 10.4 eV and a rise above 11.6 eV.
Synthesis of Mesocellular Silica Foams with Tunable Window and Cell Dimensions (2001)

Polystyrene microspheres coated with cationic surfactants are easily prepared by microemulsion polymerization. These microspheres can be used in place of surfactants to synthesize porous silica foams. The nature of the foams depends strongly upon the synthesis conditions. Under basic catalysis, “closed-cell” foams are obtained. Under acidic catalysis, open-cell foams are obtained. The windows that connect the cells of the open-cell foams are believed to arise from direct contact between adjacent spherical templates. These silica foams resemble dense aerogels.
Influence of 5-HT3 receptor antagonists in visceromotor and nociceptive responses to rectal distension before and during experimental colitis in rats (1994)

International audience
[The changes in EPH gestosis placental amino acid transport activity (using human placental microvillous membrane vesicles)]. (1987)

To elucidate the change in EPH gestosis placental amino acid transport activity, we investigated the uptake of L-alanine into microvillous membrane vesicles prepared from EPH gestosis placenta and from normal placenta by using a rapid filtration technique. 1. Alkaline phosphatase (ALP) was the marker enzyme of microvillous membrane vesicles (MMV). The ALP activity of mild EPH gestosis placental MMV didn't differ from that of normal placental MMV. On the other hand, the ALP activity of severe EPH gestosis placental MMV decreased compared to that of normal placental MMV. 2. The uptake of L-alanine into human placental MMV was dependent on the Na+ electrochemical gradient, so the transport across human placental MMV was a secondarily active one. The L-alanine transport activity of mild EPH gestosis placental MMV didn't differ from that of normal placental MMV. On the other hand, the L-alanine transport activity of severe EPH gestosis placental MMV decreased prominently compared to that of normal placental MMV.
High-Q single crystal silicon HARPSS capacitive beam resonators with self-aligned sub-100-nm transduction gaps (2003)

This paper reports on the fabrication and characterization of high-quality factor (Q) single crystal silicon (SCS) in-plane capacitive beam resonators with sub-100 nm to submicron transduction gaps using the HARPSS process. The resonating element is made of single crystal silicon while the drive and sense electrodes are made of trench-refilled polysilicon, yielding an all-silicon capacitive microresonator. The fabricated SCS resonators are 20-40 μm thick and have self-aligned capacitive gaps. Vertical gaps as small as 80 nm in between 20 μm thick silicon structures have been demonstrated in this work. A large number of clamped-free and clamped-clamped beam resonators were fabricated. Quality factors as high as 177000 for a 19 kHz clamped-free beam and 74000 for an 80 kHz clamped-clamped beam were measured under 1 mtorr vacuum. Clamped-clamped beam resonators were operated at their higher resonance modes (up to the fifth mode); a resonance frequency of 12 MHz was observed for the fifth mode of a clamped-clamped beam with the fundamental mode frequency of 0.91 MHz. Electrostatic tuning characteristics of the resonators have been measured and compared to the theoretical values. The measured Q values of the clamped-clamped beam resonators are within 20% of the fundamental thermoelastic damping limits (Q/sub TED/) obtained from finite element analysis.
High Resolution Pulse Propagation Driven Trojan Detection in Digital Logic: Optimization Algorithms and Infrastructure (2014)

Insertion of malicious Trojans into outsourced chip manufacturing generally results in increased capacitances of internal circuit nodes that have been tapped for node controllability and observability by malicious circuitry. Current path delay measurement and side channel Trojan detection techniques are unable to detect Trojans that present low loading to such tapped circuit nodes, especially in the presence of large manufacturing process variations. In this paper, a high-resolution Trojan detection method for digital logic based on pulse propagation is developed. The method exhibits 25X -- 30X higher diagnostic resolution (ability to measure small capacitive loads on internal circuit nodes) as compared to current path delay based Trojan detection techniques in the presence of significant manufacturing process variations. Further, a key benefit is that theoretically, as opposed to path delay measurement based methods, the diagnostic resolution of the test approach is independent of circuit logic depth over and above the benefits already mentioned above. Test methods and test infrastructure compatible with existing scan based techniques are described. Simulation results are presented to prove the viability and effectiveness of the proposed Trojan detection scheme and especially for circuits with large logic depths (35-70 gates) suffering from worst case process variation effects.
Evaluation of carbide capacity in CaO-based ternary systems at 1773k for refining process (2019)

Refining slags is widely used in the production of high-value-added alloys and special steels. The removal of impurities depends on the mass transfer between the slag-metal interface, and the carbide capacity of the refining slags is crucial to control the carbon content in the final products. A phenomenological model is introduced in this article for the calculation of carbide capacity of different CaO-based ternary refining slags. The contour lines of carbide capacity in CaO-Al2O3- CaF2, CaO-SiO2-CaF2 CaO-SiO2-MnO systems are calculated based on limited experimental data by the present model. The experimental data within the calculation boundary are compared with the predicted values and satisfactory agreements are observed with the mean deviation being 1.4%, 2.3%, and 1.6%, for these three systems respectively. The present model is powerful and flexible in the calculation of carbide capacity of CaO-based ternary refining slags and can be applied to other systems.
Blood analysis by Raman spectroscopy (2002)

Concentrations of multiple analytes were simultaneously measured in whole blood with clinical accuracy, without sample processing, using near-infrared Raman spectroscopy. Spectra were acquired with an instrument employing nonimaging optics, designed using Monte Carlo simulations of the influence of light-scattering-absorbing blood cells on the excitation and emission of Raman light in turbid medium. Raman spectra were collected from whole blood drawn from 31 individuals. Quantitative predictions of glucose, urea, total protein, albumin, triglycerides, hematocrit, and hemoglobin were made by means of partial least-squares (PLS) analysis with clinically relevant precision (r(2) values >0.93). The similarity of the features of the PLS calibration spectra to those of the respective analyte spectra illustrates that the predictions are based on molecular information carried by the Raman light. This demonstrates the feasibility of using Raman spectroscopy for quantitative measurements of biomolecular contents in highly light-scattering and absorbing media.