gebhart/patrepeval huggingface dataset:
Demonstration of electron beam excitation laser using a GaInN-based multiquantum well active layer (2016)

Abstract In this study, an electron beam excitation laser using a GaInN-based multiquantum well (MQW) active layer was investigated, and laser emission was observed for the first time from a GaInN-based MQW excited by an electron beam. This technology has the potential to provide access to an expanded wavelength region for the laser action of nitride-semiconductor-based lasers from deep UV to infrared.
Reducing the initial number of rituximab maintenance-therapy infusions for ANCA-associated vasculitides: randomized-trial post-hoc analysis (2020)

We were not able to detect a difference between the relapse-free survival rates for up to M12 for the D0 and D0+D14 rituximab-infusion groups, which could suggest that omitting the D14 rituximab remission-maintenance dose did not modify the short-term relapse-free rate. Nevertheless, results at M12 may also have been influenced by the rituximab-infusion strategies for both groups.
Adsorptive gossypol removal (1993)

Gossypol is extractable from cottonseed by using aqueous ethanol. The equilibrium between undissolved gossypol in cottonseed and that dissolved in the solvent determines the residual gossypol. To move the equilibrium toward extraction from the seeds, the dissolved gossypol needs to be removed from the gossypol‐solvent‐oil mixture. Gossypol removal from the mixture by adsorption on alumina, silica and molecular sieve 5Å was tested. Experimental results indicated that gossypol was more selectively adsorbed than triglycerides by these adsorbents. Alumina and silica had higher gossypol adsorption capacities than molecular sieve 5Å.
Direct analysis of curcumin in turmeric by DART‐MS (2009)

A simple chemical profiling and semi-quantitative method for natural products using DART-MS might be applied to diverse field related quality control of medicinal plants or food ingredients.
Stakeholder Management: A Universal Strategic Health Services Management Approach to Unlock a Profitable Return on Investment (2014)

There have been sustained global policy and fiscal pressures for businesses, including health care services to demonstrate unique customer-oriented entrepreneurship capabilities in terms of marketing and innovativeness, influenced by the recent global financial crisis, leading to business closures, budgetary shortfalls, and constant operational challenges for survival. For several health care managers, this entails effectively managing the increasing influence of active and powerful stakeholders to achieve a competitive advantage in terms of productive and allocative efficiency over customer-driven results and innovativeness. A focus on value addition by itself is a precursor of effective stakeholder management, clinician leadership model, and a decentralized activity based management, which integrates customer values from basic and expected services to desired and unexpected services as well as combining product quality and high quality customer services needed to usher a competitive advantage to organizations through cost leadership or product differentiation. However, a stakeholder management tool that is universally applicable across all health care business entities is still work in progress. This paper debated upon relevant previous literature on stakeholder management as a central feature for customerdriven business practices, for implementation in form of a universal stakeholder management tool, in order to advance sound entrepreneurship capabilities that support dynamic high quality customer care-driven health care and innovation.
An optimized genome-wide, virus-free CRISPR screen for mammalian cells (2021)

[This corrects the article DOI: 10.1016/j.crmeth.2021.100062.].
Three-dimensional echocardiography: assessment of inter- and intra-operator variability and accuracy in the measurement of left ventricular cavity volume and myocardial mass (2000)

Accurate left ventricular (LV) volume and mass estimation is a strong predictor of cardiovascular morbidity and mortality. We propose that our technique of 3D echocardiography provides an accurate quantification of LV volume and mass by the reconstruction of 2D images into 3D volumes, thus avoiding the need for geometric assumptions. We compared the accuracy and variability in LV volume and mass measurement using 3D echocardiography with 2D echocardiography, using in vitro studies. Six operators measured the LV volume and mass of seven porcine hearts, using both 3D and 2D techniques. Regression analysis was used to test the accuracy of results and an ANOVA test was used to compute variability in measurement. LV volume measurement accuracy was 9.8% (3D) and 18.4% (2D); LV mass measurement accuracy was 5% (3D) and 9.2% (2D). Variability in LV volume quantification with 3D echocardiography was %SEMinter = 13.5%, %SEMintra = 11.4%, and for 2D echocardiography was %SEMinter = 21.5%, %SEMintra = 19.1%. We derived an equation to predict uncertainty in measurement of LV volume and mass using 3D echocardiography, the results of which agreed with our experimental results to within 13%. 3D echocardiography provided twice the accuracy for LV volume and mass measurement and half the variability for LV volume measurement as compared with 2D echocardiography.
CAEBAT OAS/VIBE Production Release v1.1 (2015)

The objective of the project is to develop a mathematical and computational infrastructure, and modeling framework that will enable seamless multi-scale and multi-physics simulations of battery performance and safety. The modeling framework will transfer the information between models in a physically consistent and mathematically rigorous fashion for both spatial and temporal variations. The end result will be a verified, computationally scalable, portable, and flexible (extensible and easily-modified) framework that can integrate models from the other CAEBAT tasks and industrial partners. The framework will be used to validate models and modeling approaches against experiments and to support rapid prototyping of advanced battery concepts. Fig. 2 shows different parts of CAEBAT VIBE simulation environment that work together to provide user with flexibility in the problem setup, solution formulation and simulation launch. Each of the parts is discussed in subsequent sections with corresponding examples.
Ising model for neural data: Model quality and approximate methods for extracting functional connectivity (2009)

We study pairwise Ising models for describing the statistics of multineuron spike trains, using data from a simulated cortical network. We explore efficient ways of finding the optimal couplings in these models and examine their statistical properties. To do this, we extract the optimal couplings for subsets of size up to 200 neurons, essentially exactly, using Boltzmann learning. We then study the quality of several approximate methods for finding the couplings by comparing their results with those found from Boltzmann learning. Two of these methods--inversion of the Thouless-Anderson-Palmer equations and an approximation proposed by Sessak and Monasson--are remarkably accurate. Using these approximations for larger subsets of neurons, we find that extracting couplings using data from a subset smaller than the full network tends systematically to overestimate their magnitude. This effect is described qualitatively by infinite-range spin-glass theory for the normal phase. We also show that a globally correlated input to the neurons in the network leads to a small increase in the average coupling. However, the pair-to-pair variation in the couplings is much larger than this and reflects intrinsic properties of the network. Finally, we study the quality of these models by comparing their entropies with that of the data. We find that they perform well for small subsets of the neurons in the network, but the fit quality starts to deteriorate as the subset size grows, signaling the need to include higher-order correlations to describe the statistics of large networks.
Supplementary Table S4 from Clinical and Translational Results of a Phase II, Randomized Trial of an Anti–IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy (2023)

&lt;p&gt;Correlative analysis of PFS and OS with the expression of biomarkers using the 25th percentile and median marker distributions as cutpoints: total IR, IR-A, IR-B, and IGF-1R in pooled group and arm A&lt;/p&gt;
cDNA cloning of putative rat acetyl-CoA transporter and its expression pattern in brain (2000)

Rat acetyl-CoA transporter gene (Acatn) encodes a hydrophobic multi-transmembrane protein involved in the O-acetylation of gangliosides. O-acetylated gangliosides have been found to play important roles in the embryonic development of the nervous system. We have isolated rat Acatn cDNA by PCR cloning. The amino acid sequence of rat Acatn exhibited 92% and 96% homology with human and mouse sequences, respectively. The mRNA was expressed in brain at all developmental stages. Acatn expression was higher in embryonic and postnatal rats than in adult rats. Cellular localization of Acatn mRNA in adult rat brain was also analyzed by in situ hybridization. Acatn mRNA expression was detected in the neuronal cells of cerebellum, hippocampus, hypothalamus, cortex, olfactory bulb, and dorsal and ventral anterior olfactory nucleus in adult rat brain.
H. H. McNABB (1949)

He-mentioned the favourable.effect of sodium bicarbonate adminis- tered in the.first three days, and the influence of ethyl alcohol in restricting damage from adulterated liquor.Dr. H. P. Petersen stressed the possibility of extensive colloid degeneration in the retro- bulbar portion of the optic nerve, and-adduced such.achange as the- explanation for certain cases of field-defect associated with but explained only in part by colloid bodies ophthalmoscopically.visible.He suggested the simile of an iceberg, whose hidden bulk is more.menacing than its exposed pinnacle.
Optimal experiment design in closed loop with unknown, nonlinear and implicit controllers using stealth identification (2014)

We present a novel optimal experiment design method that is applicable to linear time-invariant systems regulated by unknown, nonlinear and implicitly-defined controllers. Current methods require an explicit expression for the controller in order to construct the optimal excitation spectrum. Consequently, these are limited to linearly-controlled systems. The identification scheme suggested in this paper circumvents the aforementioned requirement by ensuring that the excitation signal remains unnoticed by the controller, i.e., the identification data is gathered in an open-loop fashion. Our theoretical analysis is complemented with a numerical study on a six-parameter, single-input single-output linear system controlled by an MPC. We find that our method generates least-costly excitation signals which deliver identified models that lie close to the true system whilst honoring quality constraints, validating the novel optimal experiment design framework.
Animal Toxins Providing Insights into TRPV1 Activation Mechanism (2017)

Beyond providing evolutionary advantages, venoms offer unique research tools, as they were developed to target functionally important proteins and pathways. As a key pain receptor in the nociceptive pathway, transient receptor potential vanilloid 1 (TRPV1) of the TRP superfamily has been shown to be a target for several toxins, as a way of producing pain to deter predators. Importantly, TRPV1 is involved in thermoregulation, inflammation, and acute nociception. As such, toxins provide tools to understand TRPV1 activation and modulation, a critical step in advancing pain research and the development of novel analgesics. Indeed, the phytotoxin capsaicin, which is the spicy chemical in chili peppers, was invaluable in the original cloning and characterization of TRPV1. The unique properties of each subsequently characterized toxin have continued to advance our understanding of functional, structural, and biophysical characteristics of TRPV1. By building on previous reviews, this work aims to provide a comprehensive summary of the advancements made in TRPV1 research in recent years by employing animal toxins, in particular DkTx, RhTx, BmP01, <i>Echis coloratus</i> toxins, APHCs and HCRG21. We examine each toxin's functional aspects, behavioral effects, and structural features, all of which have contributed to our current knowledge of TRPV1. We additionally discuss the key features of TRPV1's outer pore domain, which proves to be the target of the currently discussed toxins.
Underpotential Deposition of Lithium on Aluminum in Ultrahigh-Vacuum Environments (1998)

The electrochemical properties of clean aluminum in LiClO4(PEO) solutions have been investigated in ultrahigh vacuum using as electrodes both foils and thin films vapor deposited on boron-doped diamond (BDD) layers supported on Si substrates. Voltammetric scans recorded at temperatures of about 55 °C yielded a set of deposition/stripping peaks at potentials positive to the onset of Li/Al alloy formation, attributed to Li underpotential deposition on Al. The positions of these peaks were found to be in relatively good agreement with those predicted by Gerischer−Kolb's work function correlation, as well as with recent theoretical calculations reported by Lehnert and Schmickler. In the case of Al films supported on BDD/Si, the charge under the stripping peak obtained after polarizing the Al electrode at potentials slightly positive to Li bulk deposition was found to increase with the film thickness. Further optimization of this type of experiments, by using, for example, a quartz crystal microbalance to determine the actual amount of Al deposited on the BDD/Si substrate, will make it possible to measure the stoichiometry of the alloy as a function of the applied potential.
Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions (2016)

We propose and characterize a normal and an AoCo phantom, whose hemodynamics, including velocity, flow, and pressure data are within the range of healthy volunteers and patients with AoCo. J. Magn. Reson. Imaging 2016;44:683-697.
La fabrique du doctorat en travail social (2020)

In 2000 I was invited by this journal to review a book entitled Doctorats en Travail Social: quelques initiatives europeennes, edited by Francoise Laot (Rennes, Editions de l’Ecole Nationale de la ...
Stem cells in human reproduction (2010)

Human stemcell researchhasmovedat a rapidpace since pluripotent human embryonic stem cells (hESC) were first derived from the inner cell mass of IVF preimplantation embryos (Thomson et al. 1998). This breakthrough generated much excitement amongst the scientific, medical, and general communities as the potential of hESC and their derivatives for novel cell-based therapies was anticipated. Immune rejection, teratoma formation, and ethical issues associated with hESC concurrently fuelled adult stem cell research, despite the more restricted differentiation repertoire of the latter. The recent discovery that mature tissue cells can be induced to a pluripotent state (induced pluripotent cells, iPS cells) with the introduction of up to four transcription factors (Takahashi et al. 2007) was heralded as a major step forward in stem cell research as iPS cells offer an endless supply of compatible cells for regenerative medicine purposes. Stem cells are defined by three main properties that distinguish them from their more differentiated progeny; self-renewal or ability to replace themselves, differentiation into one or more lineages, and high proliferative potential. Other features of adult stem cells are their rarity in tissues and their relative proliferative quiescence compared to their daughter transit amplifying cells. The microenvironment or stem cell niche is a crucial regulator of adult stem cell function in maintaining tissue homeostasis and initiating stem cell proliferation in response to tissue damage (Li & Xie 2005). Much research has focused on directing the differentiation of hESC into desired cell types for the study of developmental processes that cannot otherwise be studied in early human development. Protocols for deriving somatic lineages, cardiomyocytes, pancreatic, neuronal, and hematopoietic lineages, hepatocytes, and germ cells to name a few, have been developed. In this Focus Issue, Golos et al. (2010) summarize current knowledge on differentiating hESC into extraembryonic lineages, in particular trophectoderm and the various trophoblast lineages, as models for the study of early human placental development. This important advance overcomes ethical restrictions on the use of human embryos for in vitro studies and the limitations of studying mouse trophoblast differentiation which differs
At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron Variant (2022)

Abstract Plasma samples taken at different time points from donors who received either AstraZeneca (Vaxzevria) or Pfizer (Comirnaty) or Moderna (Spikevax) coronavirus disease-19 (COVID-19) vaccine were assessed in virus neutralization assays against Delta and Omicron variants of concern and a reference isolate (VIC31). With the Pfizer vaccine there was 6-8-fold reduction in 50% neutralizing antibody titres (NT 50 ) against Delta and VIC31 at 6 months compared to 2 weeks after the second dose; followed by 25-fold increase at 2 weeks after the third dose. Neutralisation of Omicron was only consistently observed 2 weeks after the third dose, with most samples having titres below the limit of detection at earlier timepoints. Moderna results were similar to Pfizer at 2 weeks after the second dose, while the titres for AstraZeneca samples derived from older donors were 7-fold lower against VIC31 and below the limit of detection against Delta and Omicron. Age and gender were not found to significantly impact our results. These findings indicate that vaccine matching may be needed, and that at least a third dose of these vaccines is necessary to generate sufficient neutralising antibodies against emerging variants of concern, especially Omicron, amidst the challenges of ensuring vaccine equity worldwide.
Intensification of Wheat Straw Pretreatment by Thermomechanical Process for Enhancement of Sugar Recovery (2011)

Wheat straw is an interesting source for ethanol production; this abundant raw material has high cellulose content. Wheat straw was pretreated with a thermomechanical process developed in our laboratory to increase the enzymatic hydrolysis extent of potentially fermentable sugars. This process involves subjecting the lignocellulosic biomass for a short time to saturated steam pressure, followed by a flash decompression to vacuum at 50 mbar. Increasing of the heat induced by the saturated steam result in intensive vapour formation in the capillary porous structure of the plant material and the subsequent release of the pressure to vacuum allows fixing the structure. The process parameters tested in this study were the moisture content of wheat straw, processing steam pressure and the number of flash release pressure. Enzymatic hydrolysis was performed on the pretreated solids by celluclast (1.5L). The results showed that the moisture content is not a critical parameter. Although processing pressure has a strong effect on hydrolysis yield, its effect on acidity is very low.
Solid‐Supported Reagents and Catch‐and‐Release Techniques in Organic Synthesis (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila (2019)

Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tightly controlled by changes in phosphorylation status. A number of molecular players have been implicated in PER destabilization by promoting PER progressive phosphorylation. On the other hand, there have been few reports describing mechanisms that stabilize PER by delaying PER hyperphosphorylation. Here we report that the protein Suppressor of Ras (SUR-8) regulates circadian locomotor rhythms by stabilizing PER. Depletion of SUR-8 from circadian neurons lengthened the circadian period by about 2 hours and decreased PER abundance, whereas its overexpression led to arrhythmia and an increase in PER. Specifically SUR-8 promotes the stability of PER through phosphorylation regulation. Interestingly, downregulation of the protein phosphatase 1 catalytic subunit PP1-87B recapitulated the phenotypes of SUR-8 depletion. We found that SUR-8 facilitates interactions between PP1-87B and PER. Depletion of SUR-8 decreased the interaction of PER and PP1-87B, which supports the role of SUR-8 as a scaffold protein. Interestingly, the interaction between SUR-8 and PER is temporally regulated: SUR-8 has more binding to PER at night than morning. Thus, our results indicate that SUR-8 interacts with PP1-87B to control PER stability to regulate circadian rhythms.
Oat Bran Fermentation by Rye Sourdough (2002)

ABSTRACT Hydration of oat bran including fermentation by rye sourdough was studied. Three types of oat bran suspensions were prepared (a control, one with whole meal rye flour added, and one with rye starter added). The suspensions were incubated for 1, 2, 3 and 4 hr. β‐Glucan content and solubilities of protein and β‐glucan were analyzed. Viscosity of the supernatants of oat bran suspensions was determined. Neither the rye sourdough nor the rye flour alone had a significant effect on the total β‐glucan content of oat bran suspensions. However, the addition of rye, either as whole meal rye flour or as sourdough starter, markedly increased the solubility of β‐glucan and proteins and simultaneously decreased the viscosity of the water‐soluble fraction of oat bran suspension. This suggests that a hydrolysis of β‐glucan had occurred that could change the rheological properties of oat bran in baking and the physiological potential of oat bran in nutrition.
Effects of Phosphate Salts on the pH Values and Rapid Visco Analyser (RVA) Pasting Parameters of Wheat Flour Suspensions (2011)

ABSTRACT Changes in pH and pasting properties of instant‐noodle formula dry‐mix suspensions containing each of 12 phosphate salts were investigated. The pH values of solutions alone and then solution and flour suspensions decreased as the level of phosphate salts increased, except that of trisodium phosphate, which increased the pH value. The changes in the Rapid Visco Analyser (RVA) pasting parameters of instant‐noodle formula suspensions were not consistent with the respective changes in pH, but the change trends of the RVA parameters for the two different wheat flours (hard red winter and soft white wheat) were similar. Five of the phosphate salts gradually increased the RVA peak viscosity (PV) as phosphate concentration increased. Seven other phosphate salts increased the PV at 0.05% and then decreased PV as the phosphate concentration increased. The change in trough viscosity owing to phosphate salt and concentration was similar to that of PV. The final viscosity (FV) gradually declined, to varying degrees, as the phosphate concentration increased for some of the phosphate salts. However, seven of the phosphate salts caused slight increases in FV as their concentrations increased. The response of starch gelatinization and pasting behavior, as measured by RVA, indicated that phosphate salts exert an influence on starch during heating in water. Because RVA parameters have been linked to instant‐noodle processing and textural properties, phosphate salt identity and concentration can likely be manipulated to affect end‐product quality.
Franse r verovert Vlaanderen (2006)

info:eu-repo/semantics/published