gebhart/patrepeval huggingface dataset:
Genetic voltage indicators (2019)

As a "holy grail" of neuroscience, optical imaging of membrane potential could enable high resolution measurements of spiking and synaptic activity in neuronal populations. This has been partly achieved using organic voltage-sensitive dyes in vitro, or in invertebrate preparations yet unspecific staining has prevented single-cell resolution measurements from mammalian preparations in vivo. The development of genetically encoded voltage indicators (GEVIs) and chemogenetic sensors has enabled targeting voltage indicators to plasma membranes and selective neuronal populations. Here, we review recent advances in the design and use of genetic voltage indicators and discuss advantages and disadvantages of three classes of them. Although genetic voltage indicators could revolutionize neuroscience, there are still significant challenges, particularly two-photon performance. To overcome them may require cross-disciplinary collaborations, team effort, and sustained support by large-scale research initiatives.
The morphology and innervation of the lateral pterygoid muscle of the dog. (1995)

The number of heads possessed by the lateral pterygoid muscle was investigated in the dog. Only a single head was observed which it is suggested may correspond to the lower head in other mammals. It inserted both onto the condyle and into the articular disc. The nerve which innervated this muscle arose directly from the mandibular nerve, separate from the medial pterygoid nerve. Because of this, it should be termed the lateral pterygoid nerve and not the pterygoid nerve.
Optimal Design of Compact Spur Gear Reductions (1992)

Abstract The optimal design of compact spur gear reductions includes the selection of bearing and shaft proportions in addition to the gear mesh parameters. Designs for single mesh spur gear reductions are based on optimization of system life, system volume, and system weight including gears, support shafts, and the four bearings. The overall optimization allows component properties to interact, yielding the best composite design. A modified feasible directions search algorithm directs the optimization through a continuous design space. Interpolated polynomials expand the discrete bearing properties and proportions into continuous variables for optimization. After finding the continuous optimum, the designer can analyze near optimal designs for comparison and selection. Design examples show the influence of the bearings on the optimal configurations.
Probing Phonons in Nonpolar Semiconducting Nanowires with Raman Spectroscopy (2011)

We present recent developments in Raman probe of confined optical and acoustic phonons in nonpolar semiconducting nanowires, with emphasis on Si and Ge. First, a review of the theoretical spatial correlation phenomenological model widely used to explain the downshift and asymmetric broadening to lower energies observed in the Raman profile is given. Second, we discuss the influence of local inhomogeneous laser heating and its interplay with phonon confinement on Si and Ge Raman line shape. Finally, acoustic phonon confinement, its effect on thermal conductivity, and factors that lead to phonon damping are discussed in light of their broad implications on nanodevice fabrication.
AN EPIDEMIOLOGICAL STUDY OF HYPOSPADIAS IN SWEDEN (1982)

ABSTRACT The prevalence at birth of hypospadias started to increase in the beginning of the 1970s, as judged from the registration in the Swedish Register of Congenital Malformations. Further studies supported the notion that the increase was real and not due to registration artifacts. A study of the geographical distribution showed an uneven distribution in the country. Three case‐control studies with different design were performed in order to find an aeti‐ological factor which could explain the observations. None was found. No support could be obtained for a role of gestagens in the aetiology of hypospadias. A hypothesis is presented based on an observation of a possibly increased infertility—possibly male—in the couples who had a boy with hypospadias. The possible implications of this finding for aetiological studies are discussed in the light of current literature. Based on a possible male subfertility, a hypothesis is presented which could explain the noticed increase in prevalence of hypospadias in the early seventies. The hypospadiac infants were analysed from various points of view. There were signs of a generally disturbed fetal development. Thus a shorter than normal gestational age with a component of growth failure was found. There was a statistically significant association, not only with other genital malformations such as retentio testis, but also with congenital heart disease, cleft lip/palate, anal atresia, and neural tube defects. The analysis indicates that this association was not random, but possibly indicates common teratogenic pathways.
Zeolite Y-Catalyzed versus Superacid-Catalyzed Protium-Deuterium Exchange in Alkanes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZeolite Y-Catalyzed versus Superacid-Catalyzed Protium-Deuterium Exchange in AlkanesJean Sommer, Mohammed Hachoumy, Francois Garin, and Denise BarthomeufCite this: J. Am. Chem. Soc. 1994, 116, 12, 5491–5492Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00091a072https://doi.org/10.1021/ja00091a072research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the use of AsH3 in the molecular beam epitaxial growth of GaAs (1981)

High-quality epitaxial layers of GaAs have been grown in a molecular beam epitaxial system using AsH3 as the arsenic source. Peak electron mobilities of over 130 000 cm2/V sec and 77-K mobilities as high as 110 000 cm2/V sec have been observed in a 5-μm-thick GaAs layer with a carrier concentration of 2.4×1014 cm−3. These layers were grown on Cr-doped semi-insulating GaAs substrates. Initial results indicate that As1 may be the preferred specie for the growth of high-purity GaAs.
Incidence and Management of Canker Stain in London Plane Trees in Modesto, California (1988)

London Plane trees in Modesto, California, are seriously threatened by canker stain, a fungus disease that has destroyed many plane trees in the eastern and southern United States. Current efforts to prevent the spread of the disease in park and street trees include the experimental use of the fungicide thiabendazole. Chemical disinfection of tools is also used when pruning plane trees. In some cases, healthy trees bordering infected trees are removed to prevent disease spread by root grafts.
Analisi e progetto di un caricabatterie con raddrizzatore trifase a PWM (2012)

Questa tesi di laurea propone il progetto di un caricabatterie reversibile trifase.
La topologia utilizzata e quella del raddrizzatore trifase di tipo boost. Le elevate correnti di ingresso rendono necessaria una analisi approfondita di alcune problematiche fra le quali la scelta dei componenti, la stima delle induttanze parassite lungo i percorsi critici della corrente ed il calcolo delle perdite dei
mosfet in presenza di induttanze parassite. Inoltre, in questa tesi, viene proposto un possibile layout del sistema che e risultato di considerazioni elettriche, magnetiche, termiche e meccaniche. Viene infine proposta una tecnica di controllo
digitale che unisce i vantaggi del controllo diretto della potenza di ingresso, modulazione vettoriale e controllo predittivo focalizzando l’attenzione sul ruolo del ritardo introdotto dall’unita che esegue l’algoritmo
Improved auditory cortex imaging using clustered volume acquisitions (1999)

The effects of the noise of echo-planar functional magnetic resonance imaging on auditory cortex responses were compared for two methods of acquiring functional MR data. Responses observed with a distributed volume acquisition sequence were compared to those obtained with a clustered volume acquisition sequence. In the former case, slices from the volume were acquired at equal intervals within the repetition time, whereas the latter acquired all slices in rapid succession at the end of the imaging period. The clustered volume acquisition provides a period of quiet during which a stimulus may be presented uninterrupted and uncontaminated by the noise of echo-planar imaging. Both sequences were implemented on a General Electric Signa imager retrofitted for echo-planar imaging by Advanced NMR Systems, Inc. The sequences were used to acquire 60 images per slice of a fixed volume of cerebral cortex while subjects were presented an instrumental music stimulus in an On vs. Off paradigm. Data were acquired for both sequences using TR values of 2, 3, 4, 6 and 8 sec. The clustered volume acquisition sequence was found to yield greater measures of dynamic range (percent signal change, mean statistical power per unit imaging time) across the tested range of TR values. Observations of more consistent spatial extent of responses, greater mean signal changes, and higher and more consistent values of mean t-statistic per unit imaging time demonstrate the efficacy of using a clustered volume acquisition for fMRI of auditory cortex. Hum. Brain Mapping 7:89–97, 1999. © 1999 Wiley-Liss, Inc.
Occurrence of Reignitions of Break Arcs When Moving Range of Arc Spots are Restricted within the Contact Surfaces (2016)

Silver contacts are separated at constant speed and break arcs are generated in a 300V-450V DC and 10A resistive circuit. The transverse magnetic field of a permanent magnet is applied to the break arcs. Motion of the break arcs, arc duration and the number of reignitions are investigated when side surfaces of the contacts are covered with insulator pipes. Following results are shown. The motion of the break arcs and the arc duration when the anode is covered with the pipe are the same as those without pipes. When the cathode is covered with the pipe, the motion of break arcs change from that without the pipes and reignitions occur more frequently. The arc duration becomes longer than that without the pipes because of the occurrence of reignitions. The number of reignition increases with increasing the supply voltage in 300V-400V. The period of occurrence of the reignition with pipes is shorter than that when the cathode is covered with the pipe.
A CASE OF URETEROUTERINE FISTULA AFTER CAESAREAN SECTION (2017)

The reported incidence rate of iatrogenic ureteral injury is 0.5 to 3% among abdominal surgery. We report a case of ureterouterine fistula after caesarean section. A 38-year-old woman visited our department with a complaint of urinary incontinence without dry time after caesarean section. Several examinations revealed right ureterouterine fistula.Ureteroneocystostomy using psoas hitch and hysterectomy was performed. We found a firm adhesion and stitches around right lower ureter over the uterus, which lead to an additional hysterectomy. After surgery, urinary incontinence had improved. Following two years after surgery, we observed no urinary incontinence or renal dysfunction.
Supplementary figures and methods from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy (2023)

&lt;p&gt;Supplementary figures 1-5 Supplementary methods&lt;/p&gt;
Comparative effects of synthetic pentasaccharide, low-molecular-weight heparin, unfractionated heparin and recombinant hirudin on the generation of factor VIIa and prothrombin activation after coagulation of human plasma (1998)

We studied the effect of synthetic pentasaccharide, a low-molecular-weight heparin (enoxaparin), unfractionated heparin and recombinant hirudin on the generation of factor VIIa (FVIIa) and prothrombin activation after in-vitro clotting of human platelet-poor plasma. FVIIa was measured with a new clotting assay that uses recombinant tissue factor truncated to interact only with FVIIa. Residual prothrombin was measured using the conventional clotting assay. FVIIa and residual FII were measured in the liquid - called pseudo-serum (psi-serum) - obtained 1 h after clotting of normal platelet-poor plasma. A kinetic study of the generation of FVIIa was also performed. Coagulation was initiated by triggering the extrinsic, the intrinsic and both associated clotting pathways. Levels of FVIIa in the psi-sera (55+/-15, 258+/-18, and 164+/-18 ng/ml, in the extrinsic, intrinsic and intrinsic + thromboplastin psi-serum respectively; values are means+/-SEM) were significantly increased compared with those in the platelet-poor plasma (3 ng/ml). Pentasaccharide, low-molecular-weight heparin and unfractionated heparin inhibited the generation of factor VIIa or its activity, or both, in a dose-dependent manner in all the experimental systems (60-90% inhibition). A kinetic study revealed that the inhibition of the generation of FVIIa by pentasaccharide and heparins starts 1 min after triggering either the extrinsic or the intrinsic clotting pathway. The downregulation of FVIIa by heparins was effected mainly by their anti-Xa activity, but also by their inhibitory effect on the generation of prothrombinase. Pentasaccharide, enoxaparin and unfractionated heparin significantly inhibited prothrombin activation in both extrinsic and intrinsic experimental system. Hirudin had no inhibitory effect either on the generation of FVIIa or on prothrombin activation in any experimental system.
EARLY FAILURE OF PRECOATED FEMORAL COMPONENTS IN PRIMARY TOTAL HIP ARTHROPLASTY (2002)

The rate of failure of roughened, precoated, cemented femoral components was considerably higher and occurred earlier than that of femoral components that were neither textured nor precoated with methylmethacrylate. Younger patients with avascular necrosis had a higher risk of failure; however, this factor alone did not completely explain the differences in outcome between these two components. The causes of aseptic loosening are multifactorial and may be related to component design and size as well as to precoating and surface finish.
Capturing, Annotating and Processing Practical Knowledge by Using Decision Trees (2016)

Practical knowledge describes the knowledge resulted from experience of a person. Capturing and processing practical knowledge is usually difficult, because it is only available in a persons head. However, this knowledge would help inexperienced persons to obtain practical knowledge in a fast way. Approaches so far have only considered how already formalized knowledge can be shared and integrated across different systems. However, capturing and formalizing practical knowledge and working around with incomplete data have not yet been considered. To address this problem we 1.) developed an open-source extension for Semantic MediaWiki that supports the graphical modeling of practical knowledge; 2.) enable to enrich the formalized practical knowledge with semantics from ontologies and knowledge graphs with references to external data sources and rules and 3.) present a technical infrastructure to automatically execute the created decision trees and thus to retrieve recommendations of the practical knowledge in real-time.
Molecular Pathways: IL11 as a Tumor-Promoting Cytokine—Translational Implications for Cancers (2014)

Emerging evidence suggests that cytokines produced by inflammatory cells act as rheostats to link the degree of wounding and local inflammation to epithelial cell survival, proliferation, and metabolism that collectively underpin the repair response. Among these cytokines, the GP130 family, which encompasses, among others, IL6 and IL11, plays a major role in orchestrating these complex processes through the activation of the latent signal transducer and activator of transcription 3 (STAT3) in the epithelium. However, many of the molecular mechanisms that govern and ensure effective epithelial wound healing and regeneration renewal also promote tumorigenesis and the progression of established cancers. Accordingly, GP130 cytokines endow the inflammatory tumor microenvironment with a capacity to promote "cancer hallmark capabilities" of the malignant epithelium, while simultaneously suppressing the antitumor response of innate and adaptive immune cells. Here, we review some recent insights derived from genetic and therapeutic inhibition of the IL6/IL11-GP130-STAT3 signaling cascade in the context of preclinical mouse models of cancer, which are likely to have implications to other solid malignancies.
Pneumococcal Capsular Polysaccharide Is Immunogenic When Present on the Surface of Macrophages and Dendritic Cells: TLR4 Signaling Induced by a Conjugate Vaccine or by Lipopolysaccharide Is Conducive (2008)

Previously, we reported that a peptide, p458, from the sequence of the mammalian 60-kDa heat shock protein (hsp60) molecule can serve as a carrier in conjugate vaccines with capsular polysaccharide (CPS) molecules of various bacteria. These conjugate vaccines were effective injected in PBS without added adjuvants. We now report that p458 conjugated to pneumococcal CPS type 4 (PS4) manifests innate adjuvant effects: it stimulated mouse macrophages to secrete IL-12 and induced the late appearance of PS4 on the macrophage surface in a TLR4-dependent manner; PS4 alone or conjugated to other carriers did not stimulate macrophages in vitro. The injection of macrophages manifesting PS4 on the surface into mice induced long-term resistance to lethal Streptococcus pneumoniae challenge. The TLR4 ligand LPS could also induce the late appearance on the surface of unconjugated PS4 and resistance to challenge in injected mice. Resistance was not induced by macrophages containing only internalized PS4 or by pulsed macrophages that had been lysed. Glutaraldehyde-fixed macrophages pulsed with PS4 did induce resistance to lethal challenge. Moreover, bone marrow-derived dendritic cells activated by LPS and pulsed with unconjugated CPS were also effective in inducing resistance to lethal challenge. Resistance induced by the PS4-pulsed bone marrow-derived dendritic cell was specific for pneumococcal CPS serotypes (type 3 or type 4) and was associated with the induction of CPS-specific IgG and IgM Abs.
Comparison of Rat and Human Parathyroid Hormone 2 (PTH2) Receptor Activation: PTH Is a Low Potency Partial Agonist at the Rat PTH2 Receptor* (1999)

The human PTH2 receptor, expressed in tissue culture cells, is selectively activated by PTH. Detailed investigation of its anatomical and cellular distribution has been performed in the rat. It is expressed by neurons in a number of brain nuclei; by endocrine cells that include pancreatic islet somatostatin cells, thyroid parafollicular cells, and peptide secreting cells in the gastrointestinal tract; and by cells in the vasculature and heart. The physiological role of the PTH2 receptor expressed by these cells remains to be determined. All pharmacological studies performed to date have used the human receptor. We have now isolated a complementary DNA including the entire coding sequence of the rat PTH2 receptor and compared its pharmacological profile with that of the human PTH2 receptor when each is expressed in COS-7 cells. PTH-based peptides, including rat PTH(1-84), rat PTH(1-34), and human PTH(1-34), have low potency at the rat PTH2 receptor for stimulation of adenylyl cyclase (EC50 = 19-140 nM). When compared with the effect of a bovine hypothalamic extract, PTH-based peptides are partial agonists at the rat PTH2 receptor. This suggests that PTH is unlikely to be a physiologically important endogenous ligand for the PTH2 receptor. A peptide homologous to an activity detected in a bovine hypothalamic extract is a good candidate for the endogenous PTH2 receptor ligand.
The Gal4-Type Transcription Factor Pro1 Integrates Inputs from Two Different MAPK Cascades to Regulate Development in the Fungal Pathogen Fusarium oxysporum (2022)

Mitogen-activated protein kinase (MAPK) signaling pathways control fundamental aspects of growth and development in fungi. In the soil-inhabiting ascomycete <i>Fusarium oxysporum</i>, which causes vascular wilt disease in more than a hundred crops, the MAPKs Fmk1 and Mpk1 regulate an array of developmental and virulence-related processes. The downstream components mediating these disparate functions are largely unknown. Here we find that the GATA-type transcription factor Pro1 integrates signals from both MAPK pathways to control a subset of functions, including quorum sensing, hyphal fusion and chemotropism. By contrast, Pro1 is dispensable for other downstream processes such as invasive hyphal growth and virulence, or response to cell wall stress. We further show that regulation of Pro1 activity by these upstream pathways occurs at least in part at the level of transcription. Besides the MAPK pathways, upstream regulators of Pro1 transcription also include the Velvet regulatory complex, the signaling protein Soft (Fso1) and the transcription factor Ste12 which was previously shown to act downstream of Fmk1. Collectively, our results reveal a role of Pro1 in integrating the outputs from different signaling pathways of <i>F. oxysporum</i> thereby mediating key developmental decisions in this important fungal pathogen.
Analysis and Monte Carlo simulations of a model for the spread of infectious diseases in heterogeneous metapopulations (2009)

We present a study of the continuous-time equations governing the dynamics of a susceptible-infected-susceptible model on heterogeneous metapopulations. These equations have been recently proposed as an alternative formulation for the spread of infectious diseases in metapopulations in a continuous-time framework. Individual-based Monte Carlo simulations of epidemic spread in uncorrelated networks are also performed revealing a good agreement with analytical predictions under the assumption of simultaneous transmission or recovery and migration processes.