gebhart/patrepeval huggingface dataset:
Circulating Hepatitis B Surface Antigen Particles Carry Hepatocellular microRNAs (2012)

Hepatitis B virus (HBV) produces high quantities of subviral surface antigen particles (HBsAg) which circulate in the blood outnumbering virions of about 1\10(3-6) times. In individuals coinfected with the defective hepatitis Delta virus (HDV) the small HDV-RNA-genome and Delta antigen circulate as ribonucleoprotein complexes within HBsAg subviral particles. We addressed the question whether subviral HBsAg particles may carry in the same way cellular microRNAs (miRNAs) which are released into the bloodstream within different subcellular forms such as exosomes and microvescicles. Circulating HBsAg particles were isolated from sera of 11 HBsAg carriers by selective immunoprecipitation with monoclonal anti-HBs-IgG, total RNA was extracted and human miRNAs were screened by TaqMan real-time quantitative PCR Arrays. Thirty-nine human miRNAs were found to be significantly associated with the immunoprecipitated HBsAg, as determined by both comparative DDCT analysis and non-parametric tests (Mann-Whitney, p<0.05) with respect to controls. Moreover immunoprecipitated HBsAg particles contained Ago2 protein that could be revealed in ELISA only after 0.5% NP40. HBsAg associated miRNAs were liver-specific (most frequent = miR-27a, miR-30b, miR-122, miR-126 and miR-145) as well as immune regulatory (most frequent = miR-106b and miR-223). Computationally predicted target genes of HBsAg-associated miRNAs highlighted molecular pathways dealing with host-pathogen. The finding that HBsAg particles carry selective pools of hepatocellular miRNAs opens new avenues of research to disentangle the complex interactions between host and HBV and provides a non invasive tool to study the physiopathology of liver epigenetics.
A new active filter for power factor compensation (2003)

This paper presents a new method for reactive power compensation including active filtering of the mains supply. Two instantaneous electrical measurement quantities, shifting reactive power and system load exchange reactive power, are introduced for power state analysis in nonsinusoidal conditions. If the time reference is selected properly, the shifting reactive power and the system load exchange reactive power can be represented very conveniently in a d-g system. Based on the new method, used to analyze reactive power in nonsinusoidal conditions, a digital controller of an active filter is described. Finally results of computer simulation are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and Kinematic Evaluation of a Novel Joint-Specific Play Controller: Application for Wrist and Forearm Therapy (2015)

This study presented the concept, development, and wrist tracking accuracy of an inexpensive approach to extremity therapy that may have a health benefit for children with hemiparesis, and potentially for patients of any age with a wide range of extremity neuromotor impairments.
A novel high-voltage high-speed MESFET using a standard GaAs digital IC process (1994)

A novel gallium arsenide high-voltage MESFET structure (HVFET) suitable for high-voltage, high-speed output drivers is described. The device uses an extended drain region and a two-step gate field plate structure to achieve high breakdown voltage of 130 V. The device is implemented using a standard GaAs enhancement/depletion MESFET digital IC process without any additional processing steps and exhibits turn-on and turn-off times under 200 ps.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
One Hundred Channel Selectable Surface Wave Bandpass Filter (1974)

Surface wave multichannel bandpass filters such as the selectable filters, filter trees, or filter banks provide a large number of bandpass filter channels with relatively few transducers. Among major systems applications are frequency-hopped receivers, spread-spectrum equipment,and multichannel multiplex systems. Synthesis of more than 100 bandpass responses of varying center frequency and varying bandwidth with nominally 20 transducers is detailed.
Measurements of nonequilibrium interatomic forces using time-domain x-ray scattering (2021)

We demonstrate an experimental approach to determining the excited-state interatomic forces using femtosecond x-ray pulses from an x-ray free-electron laser. We determine experimentally the excited-state interatomic forces that connect photoexcited carriers to the nonequilibrium lattice dynamics in the prototypical Peierls-distorted material, bismuth. The forces are obtained by a constrained least-squares fit of a pairwise interatomic force model to the excited-state phonon dispersion relation as measured by the time- and momentum-resolved x-ray diffuse scattering. We find that photoexcited carriers weaken predominantly the nearest-neighbor forces, which drives the measured softening of the transverse acoustic modes throughout the Brillouin zone as well as the zone-center ${A}_{1g}$ optical mode. This demonstrates a bond-selective approach to measuring electron-phonon coupling relevant to a broad range of photoinduced phase transitions and transient light-driven states in quantum materials.
Energy-Efficient On–Off Power Control of Femto-Cell Base Stations for Cooperative Cellular Networks (2016)

Improving energy efficiency (EE) of mobile communication systems (MCSs) has been considered a key aim in recent years, and has been the subject of intense research interest. One of the simplest yet most powerful ways to increase the EE is to turn off redundant communication entities whose operation does not greatly affect the overall performance of the MCS. In this paper, we propose a novel on–off power control scheme for femto-cell base stations (FBSs) considering cooperative transmission in which multiple FBSs collaborate on the same data transmission. In the proposed scheme, the operation of the redundant FBSs is halted in an adaptive manner. For the proper determination of redundant FBSs with low computational complexity, we propose using the level of contribution (LOC), which specifies the importance of a given FBS in the cooperative transmission. Redundant FBSs are chosen based on their LOC value, and these FBSs are turned off in order to reduce the power consumption of MCSs while minimizing the degradation of the overall throughput of cooperative transmissions. The performance of the proposed scheme is verified through extensive simulations, which shows that near-optimal performance can be achieved without excessive computations.
An Energy-Efficient and High Throughput in-Memory Computing Bit-Cell With Excellent Robustness Under Process Variations for Binary Neural Network (2020)

In-memory computing (IMC) is a promising approach for energy cost reduction due to data movement between memory and processor for running data-intensive deep learning applications on the computing systems. Together with Binary Neural Network (BNN), IMC provides a viable solution for running deep neural networks at the edge devices with stringent memory and energy constraints. In this paper, we propose a novel 10T bit-cell with a back-end-of-line (BEOL) metal-oxide-metal (MOM) capacitor laid on pitch for in-memory computing. Our IMC bit-cell, when arranged in a memory array, performs binary convolution (XNOR followed by Bit-count operations) and binary activation generation operations. We show, when binary layers of BNN are mapped into our IMC arrays for MNIST digit classification, 98.75% accuracy with energy efficiency of 2193 TOPS/W and throughput of 22857 GOPS can be obtained. We determine the memory array size considering the word-line and bit-line nonidealities and show how these impact classification accuracy. We analyze the impact of process variations on classification accuracy and show how word-line pulse tunability provided by our design can be used to improve the robustness of classification under process variations.
In vivo and in vitro biological activities of two human cell lines derived from anaplastic lung cancers. (1983)

Cell lines Lu-65 and SK-Luci-6 were established from two patients with anaplastic (non-oat cell) lung cancers. These cell lines showed in vivo and in vitro functional activities that could explain the paraneoplastic syndromes which were clinically manifested. In both patients, elevated white blood cell counts occurred in the absence of any evidence of sepsis. Tumor fragments taken directly from one patient and transplanted to nude mice produced a progressive leukocytosis in the mice. Tissue culture-derived cells from both cell lines enhanced white blood cell numbers following heterotransplantation to nude mice. Cell-free extracts from both cell lines were found to enhance granulocyte-macrophage colony formation in soft agar. Greater colony formation was consistently found with the cell line (SK-Luci-6) that was derived from the patient manifesting the more marked leukocytosis. These data suggest that the tumor cells release colony-stimulating activities. Coincidently, one cell line (Lu-65) synthesized and released large amounts of prostaglandin E2 with little or no other prostaglandin product; the other cell line produced no prostaglandins. When the tumor cell lines were cocultured with explanted fetal rat bones, enhanced bone resorption with excessive calcium release occurred. Bone-resorbing activity correlated with tumor prostaglandin synthesis for the cell line releasing prostaglandin E2. An osteolytic factor that was neither prostaglandin nor parathyroid hormone was released by the SK-Luci-6 cell line. Hypercalcemia was a persistent feature only in the patient from whom the latter tumor line was derived.
Study of an Electro-Optic Leaky Waveguide Deflector for Application in All-Optical Analog-to-Digital Converters (2016)

International audience
An Efficient Radio Resource Re-Allocation Scheme for Delay Guaranteed Vehicle-to-Vehicle Network (2016)

To achieve low delay for vehicular communication in cellular networks, the use of direct device-to-device (D2D) communication among vehicles is regarded as a key functional requirement. When D2D users share the spectrum with regular cellular users (D2D underlay), resource allocation schemes assure the coexistence between D2D and cellular users. Due to the high mobility of the vehicles, the resources need to be reallocated, but frequent updates cause high signaling overhead and degrade the delay performance. In this paper, we present a radio resource re-allocation scheme for vehicular D2D users in a platoon scenario. The scheme reduces the re-allocation rate and gives delay guarantees for each vehicle.With the help of Lyapunov optimization, a closed form of the upper delay bound and resource re-allocation rate is also derived. The simulation results show that the proposed scheme can provide an delay upper bound and simultaneously minimizes the resource re-allocation rate.
Lignite/coal injection system installed at the ARBED ESCH-BELVAL Works (1981)

Malignant peripheral nerve sheath tumors (MPNSTs) develop in patients with underlying NF1, and usually arise as a result of malignant transformation of a pre-existing plexiform neurofibroma. The clonal cytogenetic abnormalities reported in primary MPNST include complex karyotypes with chromosome numbers in the triploid or tetraploid range with recurrent abnormalities of several chromosomes including losses or imbalances. As a prelude to cell biological, pharmacological, and functional studies to investigate pathways and gene(s) associated with multistep tumorigenesis, which includes progression, metastasis and resistance to therapy in MPNST, detailed molecular cytogenetic and genetic analyses of cell lines from primary, metastatic and recurrent MPNST with underlying NF1 disorder have been performed. The clonal cytogenetic abnormalities detected in the primary tumor cell line were similar to those observed in primary cultures of this tumor. Due to the complexity of the rearrangements seen by G-banded karyotype analysis, further characterization of the clonal abnormalities in these three cell lines was performed by molecular cytogenetic techniques, including CGH and SKY. CGH analysis detected recurrent deletions of 9p, 12q21-q32, complete losses of the X-chromosome, and gains of the chromosomal segment 17q25 in all three cell lines. SKY analysis detected extensive clonal abnormalities in these cell lines. The nature and the alterations of the cell cycle regulators, particularly those associated with G1-S checkpoints and known to be deregulated in MPNST, were studied. These cell cycle regulators included those associated with Rb1-cyclin D1 and the p53 pathways. The findings are consistent with the argument that an imbalance between the cyclin activators of CDKs and inhibitory proteins such as p16 result in uncontrollable proliferation in the cell lines, associated with progression of the disease. LOH and expression of the p53 gene in metastatic and recurrent cell lines was observed, as reported by others. The role of biallelic inactivation of p53 gene in MPNST with underlying NF1 mutations, however, needs further study. Overexpression of Rb1-protein observed in metastatic and recurrent cell lines is indicative of its role in the progression of the disease. One of the most important observations of this study is that Nm23-H1 expression is closely associated with advanced or metastatic disease. In summary, MPNST cell lines derived from a patient with metastatic and recurrent disease with NF1 disorder were characterized and a gene associated with metastatic potential which is amenable to therapeutic and chemo-preventative approaches was identified. These cell lines with extensive characterization of genetic abnormalities are likely to provide important reagents for biochemical, molecular and pharmacological studies related to MPNST.
A multicomponent, elicitor‐inducible cystatin complex in tomato, Solanum lycopersicum (2007)

We assessed the ability of the fungal elicitor arachidonic acid to induce cystatin genes in tomato (Solanum lycopersicum), using a cDNA expression library from arachidonate-treated leaves. The cDNAs of two novel cystatins were isolated, coding for an approx. 11-kDa protein, SlCYS10; and for a 23.6-kDa protein, SlCYS9, bearing an N-terminal signal peptide and a long, 11.5-kDa extension at the C terminus. Both genes were induced by arachidonate but not by methyl jasmonate, an inducer of the 88-kDa eight-unit cystatin, multicystatin, accumulated in the cytosol of leaf cells upon herbivory. A truncated form of SlCYS9, tSlCYS9, was produced by deletion of the C-terminal extension to assess the influence of this structural element on the cystatin moiety. As shown by kinetic and stability assays with recombinant variants expressed in Escherichia coli, deleting the extension influenced both the overall stability and inhibitory potency of SlCYS9 against cysteine proteases of herbivorous organisms. These findings provide evidence for a multicomponent elicitor-inducible cystatin complex in tomato, including at least 10 cystatin units produced via two metabolic routes.
Emission color tunable light-emitting diodes composed of InGaN multifacet quantum wells (2008)

We demonstrate that the apparent emission colors of InGaN-based light-emitting diodes using microstructured multifacet quantum wells as active layers can externally be controlled over a wide spectral range that encompasses green to blue or white at a color temperature of 4000K to blue along the Planckian locus. The controllability relies on facet-dependent polychromatic emissions. The pulsed current operation with the appropriate duties varied their relative intensities and the consequent apparent colors without seriously affecting the total number of emitted photons, particularly for the blue to green variation.
Nanobody-Based Lateral Flow Immunoassay for the Rapid Detection of Aflatoxin B1 in Almond Milk (2022)

Aflatoxin B1 (AFB1) is the most potent genotoxic and carcinogenic aflatoxin produced by Aspergillus flavus and Aspergillus parasiticus. AFB1 is considered a major concern in food safety because of its high toxicity and possible contamination of a variety of food commodities such as cereals, groundnuts, tree nuts, and milk. To guarantee the food safety and address health concerns of consumers, it is important to monitor the contamination of the food chain with this toxin. Screening and regular testing for aflatoxin are mainly done by reference laboratories from the European Union (EU) and the United States (US), using sensitive but low-throughput technologies, thus limiting the frequency of product testing. The problem is still more serious in developing countries, where contamination is often high and rapid field methods are needed. New technologies are needed to provide broader, more thorough and efficient screening for these mycotoxins. In this context, we present the development of a lateral flow immunoassay (LFIA) for the detection of AFB1 as a semiquantitative approach. We have combined the advantages of engineered nanobodies specific to AFB1 with an easy fluorescence read-out system of green fluorescence protein (GFP) fused as a label to a specific nanobody. Optimized LFIA reached a limit of detection (LOD) of 4.80 ng/mL in undiluted almond milk. Because of lifestyle changes, there is an increasing demand for almond milk compared to dairy products. Almond milk is susceptible to contamination with aflatoxin and thus was selected as a food matrix for AFB1 monitoring. The U.S. Food and Drug Administration (FDA) and the European Commission established an action level or maximum residue level of 20 and 8 ng/mL for almond milk, respectively. The developed LFIA has been optimized to distinguish between compliant/noncompliant samples taking into consideration the signal provided by the control line (CL). The CL signal has been set as a threshold of the maximum residue level (MRL) signal (TL). A validation study has been performed and blind samples have been measured successfully.
Supplementary Table from The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation (2023)

Supplementary Table from The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Predicting POI Visits in a Heterogeneous Location-Based Social Network (2016)

A point of interest (POI) is a specific location that people may find useful or interesting, such as restaurants, stores, attractions, and hotels. With the recent proliferation of location-based social networks (LBSN), numerous users gather to interact and share information on various POIs. POI recommendations have become a crucial issue because it not only helps users to learn about new places but also gives LBSN providers chances to post POI advertisements. As we utilize a heterogeneous information network to represent an LBSN in this work, POI recommendations are remodeled as a link prediction problem, which is significant in the field of social network analysis. Moreover, we propose to utilize the meta-path-based approach to extract implicit but potentially useful relationships between a user and a POI. Then, the extracted topological features are used to construct a prediction model with appropriate data classification techniques. In our experiments, the Yelp dataset is utilized as our testbed for performance evaluation purposes. The results show that our prediction model is of good prediction quality in practical applications.
Microstrip-fed bow-tie-shaped meander slot antenna with compact and broadband characteristics (2005)

In this paper, a miniaturized bow-tie-shaped meander-slot antenna is proposed to achieve wideband characteristics. In general, conventional bow-tie slot antennas have broadband characteristics, while meander-type slot antennas have relatively small size. The proposed antenna geometry is a variation of the meander-slot antenna, incorporating the bow-tie shape to realize a miniaturized antenna having a relatively large bandwidth. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 45: 88–90, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20732
Vascular connections of the lateral wall of the sinus: surgical effect in sinus augmentation. (2009)

Knowledge of the arterial supply is essential for surgical treatment in the sinus area. A CT scan is recommended and the radiologist must be advised to search for intraosseous or extraosseous vessels in the lower two thirds of the maxillary sinus.
Status of FY 1988 soil-water balance studies on the Hanford site (1989)

Natural recharge (i.e., the amount of water from meteorological sources, such as rainfall or snowmelt, that infiltrates through the vadose zone to the groundwater table) at the Hanford Site is a variable quantity because it depends on soil, plant, and climatic factors that vary in time and space over the Site. Water balance data have been collected at selected locations at the Hanford Site for the past 10 years in an attempt to measure or estimate natural recharge for known soil, plant, and climatic conditions. The data collected include precipitation, neutron probe measured water content (storage), and drainage measurements from lysimeters. The lysimeter studies provided the first quantitative estimates of natural recharge at the Hanford Site. 12 refs., 40 figs., 11 tabs.
Sex differences in the association between albumin and all‐cause and vascular mortality (2009)

This study demonstrates a strong inverse association between serum albumin and mortality in a large patient cohort. The predictive value of low albumin was remarkably higher in men than in women.
Solution‐Phase Synthesis of Combinatorial Libraries Designed to Modulate Protein—Protein or Protein—DNA Interactions (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Hypothesis-driven data abstraction with trend templates. (1993)

We have written a prototype computer program called TrenDx for automated trend detection during process monitoring. The program uses a representation called trend templates that define disorders as typical patterns of relevant variables. These patterns guide the assignment of primary data to abstracted intervals or phases of the monitored process. TrenDx has been applied to the task of pediatric growth monitoring. The results of an exploratory clinical trial are reviewed here. The general utility of TrenDx for clinical trend detection and diagnosis is illustrated with examples from several task domains.
A new mutation in TUBB1 associated with thrombocytopenia confirms that C‐terminal part of β1‐tubulin plays a role in microtubule assembly (2016)

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