gebhart/patrepeval huggingface dataset:
Acute Estrogen Does Not Augment the β 2 ‐ Adrenergic Receptor Mediated Vasodilation in Postmenopausal Women (2018)

Introduction Acute estrogen infusion augments β 2 ‐adrenergic receptor responsiveness in premenopausal women. This suggests an influential role of estrogen in controlling the vasodilator responsiveness via β 2 ‐adrenergic receptors in premenopausal women. Postmenopausal women present with a reduced β 2 ‐adrenergic receptor responsiveness as compared to premenopausal women. This divergent finding in β 2 ‐adrenergic receptor responsiveness could be due to loss of endogenous estrogen postmenopause. Objective Hence, the objective of the study was to compare the β 2 ‐adrenergic vasodilator responses with and without estrogen in postmenopausal women. We hypothesized that the vasodilator effects during endothelial dependent, independent and during β 2 ‐adrenergic agonist infusion would be significantly greater with acute, local estrogen administration. Methods Venous occlusion plethysmography was used to measure forearm blood flow (FBF) in 8 older (age = 59 ± 1 years) healthy, non‐obese (BMI = 23 ± 1 kg/m 2 ) women. FBF was measured at baseline and during an intra‐arterial infusion of acetylecholine (ACH) at 1.0, 2.0, 4.0, and 8.0 μg/100 ml tissue/min, sodium nitroprusside (NTP) at 0.25, 0.5, 1.0 and 2.0 ug/100 ml tissue/min and terbutaline (β 2 agonist) at 0.1, 0.5, 1.0, 2.0 μg/100 ml tissue/min before (with dextrose co‐infusion) and during acute, local intra‐arterial infusion of estrogen (20 ηg/mL at 1 mL/min). Forearm vascular conductance (FVC) was calculated as FBF divided by mean arterial pressure. Area under the curve (AUC) was calculated for the absolute FVC and percent baseline FVC of ACH, NTP and terbutaline. Results There were no significant differences in FVC with estrogen infusion as compared to control during ACH, NTP and all terbutaline doses except dose 2 of ACH (Table 1). The AUC are not significantly different during estrogen (p&gt;0.05) as compared to control for ACH, NTP and terbutaline (figure 1). Conclusions These data suggest that acute administration of estrogen, which corresponds to the endogenous levels of estrogen seen in premenopausal women during mid‐cycle, does not augment the β 2 ‐adrenergic vasodilator responses in postmenopausal women. Additionally, these data suggest that estrogen infusion does not increase the endothelial dependent and independent vasodilatory capacity in postmenopausal women. Support or Funding Information HL83947 (MJJ) and Mayo Clinic Women's Health Scholarship (K12 HD065987). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Einfaches Verfahren zur Bestimmung der Wärmeleitfähigkeit von Stählen / A simple procedure for the determination of the thermal conductivity of steels / Un procédé simple pour la détermination de la conductivité thermique des aciers (1971)

Article Einfaches Verfahren zur Bestimmung der Wärmeleitfähigkeit von Stählen / A simple procedure for the determination of the thermal conductivity of steels / Un procédé simple pour la détermination de la conductivité thermique des aciers was published on July 1, 1971 in the journal Materials Testing (volume 13, issue 7).
Modeling weight round robin packet scheduler with Petri nets (2003)

This paper introduces a model using Petri nets for weight round robin (WRR) packet scheduler for Ethernet switches. This model uses the IEEE 802.1Q specification to schedule seven different classes of services in order to support quality of service at link layer. The proposed model can be used in performance analysis simulations and to educational purpose.
A Review of Sentiment Semantic Analysis Technology and Progress (2017)

Sentiment computing brings some new application opportunities and technique challenges in artificial intelligence of the next generation, and it has become a fascinating research field. In this paper, the conception of sentiment computing with some core elements and feature vectors is defined, and some vital issues are proposed. Based on the theories mentioned above, the subjective content or objective content is classified by some special algorithms in the scenarios of single modal, such as text, image, audio and video data. Furthermore, how to merge these different kinds of data and to form the multimodal analysis methods for emotion detection is an important problem, and the fusion strategy is summarized in the paper. Finally, some trends about the sentiment cognition and sentiment generation are analyzed, which provides new ways for further research work.
Structural Heterogeneity and Coordination Chemistry of Nickel(II) Octaethyl-meso-nitroporphyrins (1994)

The role of steric crowding of peripheral substituents in causing nonplanar distortions of the porphyrin macrocycle has been investigated in a series of nickel(II) meso-nitrooctaethylporphyrins as models for protein-induced nonplanar distortions of metal-tetrapyrrole cofactors. UV-visible absorption spectra, resonance Raman spectra, nuclear magnetic resonance spectra, and molecular mechanics calculations are given for nickel(II) derivatives of 5-mono-, 5, 15-di-, 5, 10-di-, 5, 10, 15-tri-, and 5, 10, 15, 20-weso-nitro-substituted octaethylporphyrins. The frequencies of the structure-sensitive Raman lines are found to shift to lower energies in response to sterically induced nonplanar distortion of the porphyrin macrocycle rather than in response to the addition of a strong electron-withdrawing nitro substituent. The Raman spectra of all except tetranitrooctaethylporphyrin show spectroscopic evidence of heterogeneity resulting from the presence of conformers with differing degrees of nonplanarity. Evidence from UV-visible absorption spectra, nuclear magnetic resonance spectra, and molecular mechanics calculations suggests that nickel tetranitrooctaethylporphyrin in solution may exhibit conformers with different types of nonplanar distortions which however do not differ in the relative degree of distortion. We find that the effect of increasing distortion on the chemical reactivity with axial ligating agents, which normally acts to lower the affinity, is overcome in the case of the nitrooctaethylporphyrin series by the increasing electron depletion of the porphyrin ring as the number of nitro substituents increases.© 1994, American Chemical Society. All rights reserved.
An autonomic operating environment for large-scale distributed applications (2006)

This paper presents the OptimalGrid Operating Environment, and shows how it tackles the difficulty of automatically building, distributing and running connected distributed parallel programs. One of the main goals of OptimalGrid is to hide the comple
Short pulse lasetr processing characteristics of transparent materials (2019)

Short pulsess laser processing is a very important technique for transparent materials such as glass substrates of information and communication devices. However, the research has not sufficiently advanced on the ablation processing, because the processing phenomenon is complicated, since the processing mechanism is different by the pulse duration. In this study, in order to investigate the processing characteristics of transparent materials using a short pulse laser, single irradiation with pulse duration of nanosecond and femtosecond on a fused silica plate of 1 mm thickness was performed, And the processing threshold and hole shape were evaluated.
<p>Dry eye disease ranking among common reasons for seeking eye care in a large US claims database</p> (2019)

This study provided further epidemiologic evidence for DED as a commonly occurring condition that drives patients to seek treatment.
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt (2022)

Mechanistic target of rapamycin complex 2 (mTORC2) is a multi-subunit kinase complex, central to multiple essential signaling pathways. Two core subunits, Rictor and mSin1, distinguish it from the related mTORC1 and support context-dependent phosphorylation of its substrates. mTORC2 structures have been determined previously; however, important questions remain, particularly regarding the structural determinants mediating substrate specificity and context-dependent activity. Here, we used cryo-EM to obtain high-resolution structures of the human mTORC2 apo-complex in the presence of substrates Akt and SGK1. Using functional assays, we then tested predictions suggested by substrate-induced structural changes in mTORC2. For the first time, we visualized in the apo-state the side chain interactions between Rictor and mTOR that sterically occlude recruitment of mTORC1 substrates and confer resistance to the mTORC1 inhibitor rapamycin. Also in the apo-state, we observed that mSin1 formed extensive contacts with Rictor via a pair of short α-helices nestled between two Rictor helical repeat clusters, as well as by an extended strand that makes multiple weak contacts with Rictor helical cluster 1. In co-complex structures, we found that SGK1, but not Akt, markedly altered the conformation of the mSin1 N-terminal extended strand, disrupting multiple weak interactions while inducing a large rotation of mSin1 residue Arg-83, which then interacts with a patch of negatively charged residues within Rictor. Finally, we demonstrate mutation of Arg-83 to Ala selectively disrupts mTORC2-dependent phosphorylation of SGK1, but not of Akt, supporting context-dependent substrate selection. These findings provide new structural and functional insights into mTORC2 specificity and context-dependent activity.
An Investigation of First Grade Children's Use of Language Structure. (1971)

One of the more fascinating aspects of pre-school children's verbal language seems to be their uncanny ability to speak in complete sentences. From the time children put two words together meaning fully, they speak in sentences. By the time they arrive in first grade they use simple, compound, and complex sentences. Children can also supply nouns for subjects, verbs for predicates, nouns for objects, and the like.
Emulating the Logic of Monoterpenoid Alkaloid Biogenesis to Access a Skeletally Diverse Chemical Library (2013)

We have developed a synthetic strategy that mimics the diversity-generating power of monoterpenoid indole alkaloid biosynthesis. Our general approach goes beyond diversification of a single natural product-like substructure and enables production of a highly diverse collection of small molecules. The reaction sequence begins with rapid and highly modular assembly of the tetracyclic indoloquinolizidine core, which can be chemoselectively processed into several additional skeletally diverse structural frameworks. The general utility of this approach was demonstrated by parallel synthesis of two representative chemical libraries containing 847 compounds with favorable physicochemical properties to enable its subsequent broad pharmacological evaluation.
The Preparation and Properties of Vanadium Pentafluoride1 (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Properties of Vanadium Pentafluoride1L. E. Trevorrow, J. Fischer, and R. K. SteunenbergCite this: J. Am. Chem. Soc. 1957, 79, 19, 5167–5168Publication Date (Print):October 1, 1957Publication History Published online1 May 2002Published inissue 1 October 1957https://doi.org/10.1021/ja01576a023RIGHTS & PERMISSIONSArticle Views129Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (270 KB) Get e-Alertsclose Get e-Alerts
Spectral path entanglement of photons using the all-optical Stern-Gerlach effect (2019)

We show that proper engineering of a nonlinear interaction induces quantum entanglement between the spatial and spectral degrees of freedom of incident photons via the all-optical analogue of the Stern-Gerlach effect.
Binary polarization-shift-keyed modulation for interplanetary CubeSat optical communications (2017)

Recent developments for laser communication on CubeSats across interplanetary distances will be presented. A binary polarization-shift-keyed modulation scheme using dual gain-switched diode lasers is developed and demonstrated within an end-to-end link testbed to achieve signal acquisition under extremely poor signal-to-noise conditions (-43.5 dB average signal-to-noise power ratio at a 1-MHz symbol rate) to simulate direct-to-Earth links, while simultaneously targeting a limited SWaP footprint (1.5U envelope). Additional system design and constraints for the compact laser transmitter will be discussed.
Combining Local and Global Features for 3D Face Tracking (2017)

In this paper, we propose to combine local and global features in a carefully designed convolutional neural network for 3D face alignment. We firstly adopt a part heatmap regression network to predict the landmark points on a local granularity by generating a series of heatmaps for each 3D landmark point. To enhance the ability of local feature representation, we incorporate the designed network with a part attention module, which transfers the convolution opereation into a channelwise attention opereation. Additionally, we take all these heatmaps alongside the input image as the input of another shape regression network in order to model the feature representations from local discrete regions to a global semantically continuous space. Extensive experiments on challenging datasets, AFLW2000-3D, 300VW and the Menpo Benchmark, show the effectiveness of both the global consistency and local description in our model, and the proposed algorithm outperforms state-of-the-art baselines.
Moving too fast (1998)

The Fallon Inquiry into the personality disorder unit at Ashworth special hospital finished taking evidence last week. Steve Flanagan looks at the nursing issues that failed to hit the headlines
Rotor Fault Detection and Identification on a Hexacopter under Varying Flight States Based on Global Stochastic Models (2020)

This work introduces the use of "global" stochastic models to detect and identify rotor failures in multicopters under different operating conditions, turbulence, and uncertainty. The identification of an extended class of time-series models known as Vector-dependent Functionally Pooled AutoRegressive models, which are characterized by parameters that depend on both forward velocity and gross weight, using scalar or vector aircraft response signals under white noise excitation has been described. A concise overview of the residual based statistical decision making schemes for fault detection and identification of rotor failures is provided. The scalar and vector statistical models, along with residual variance and residual uncorrelatedness methods were validated and their effectiveness was assessed by a proof-of-concept application to aircraft flight for healthy and faulty states under severe turbulence and intermediate operating conditions. The results of this study demonstrate the effectiveness of all the proposed residual-based time series methods in terms of prompt rotor fault detection, although the methods based on Vector AutoRegressive models exhibit improved performance compared to their scalar counterparts with respect to their performance in identifying rotor failures in the post-failure controller compensated state.
Sexual Satisfaction and Frequency of Orgasm in Women with Chronic Pelvic Pain due to Endometriosis (2020)

Abstract Background Dyspareunia, one of the main symptoms of the chronic gynecological pelvic pain disorder endometriosis, may interfere with the likelihood of reaching an orgasm, yet for women with dyspareunia, no data on orgasm rates in different sexual activities are available. Aim The aim of this study was to evaluate the ability to reach an orgasm and its association with sexual satisfaction during different sexual activities in women with a chronic pelvic pain disorder and in healthy control women. Methods A set of questionnaires including the brief index of sexual functioning and global sexual functioning was used to evaluate sexuality in women affected with endometriosis (n = 434) and a nonaffected control group (n = 434) recruited in German-speaking countries. Outcomes The primary outcome measure of this study was the orgasm rate during different types of sexual activities. Results Only the ability to have an orgasm during sexual intercourse (P = .002) but not during masturbation (P = .509) or partnered noncoital sexual activities (P = .229) is affected by endometriosis. Dyspareunia was associated with a reduced ability to experience an orgasm during intercourse for endometriosis patients (P = .020) and control women (P = .006). The ability to orgasm during noncoital sexual activities (P = .006) and sexual intercourse (P = .038) was associated with a higher sexual satisfaction in women with endometriosis. For controls, only the ability to achieve an orgasm with sexual intercourse was associated with sexual satisfaction (P = .038). Clinical implications Sexual counselling as part of medical support could help couples living with chronic pelvic pain of the female partner integrate noncoital sexual activities in their sex lives, leading to fewer sex-related problems and higher sexual desire and satisfaction. Strengths and limitations This study is the first to examine different ways of achieving an orgasm and sexual satisfaction in a large group of women with endometriosis and a matched control group. The breadth of the questionnaire allowed a differentiated analysis of factors influencing the likelihood of achieving an orgasm and overall sexual satisfaction. The one limitation is that the length and the intimate nature of the questionnaire possibly resulted in reluctance to answer this part of the questionnaire. Conclusion Partnered noncoital sexual activities may represent an alternative to reach orgasm for women with endometriosis-related chronic pelvic pain or anorgasmia during sexual intercourse.
Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hyperinsulinemic euglycemic clamp (2023)

These results suggest a change in a small number of differentially expressed proteins. A possible reason for this small change could be our study cohorts representing a homogeneous and healthy population. Additionally, we show differences in protein levels from skeletal muscle in low and high insulin sensitivity groups. Therefore, these differences may represent early events for the development of insulin resistance, pre-diabetes, and type 2 diabetes.
Dimensionality Reduction Based on Tensor Modeling for Classification Methods (2009)

Dimensionality reduction (DR) is the key issue to improve the classifiers' efficiency for hyperspectral images (HSIs). In this paper, principal component analysis (PCA), independent component analysis, and projection pursuit (PP) approaches to DR have been investigated. These matrix-algebra methods are applied on vectorized images. Thereof, the spatial rearrangement is lost. To jointly take advantage of the spatial and spectral information, HSI has been recently represented as tensor. Offering multiple ways to decompose data orthogonally, we introduced DR methods based on multilinear-algebra tools. The DR is performed on spectral way using PCA, or PP, joint to an orthogonal projection onto a lower subspace dimension of the spatial ways. We show the classification improvement using the introduced methods in function to existing methods. This experiment is exemplified using real-world HYDICE data.
Electron emitting filaments for electron discharge devices (2023)

Electrons are copiously emitted by a device comprising a loop-shaped filament made of lanthanum hexaboride. The filament is directly heated by an electrical current produced along the filament by a power supply connected to the terminal legs of the filament. To produce a filament, a diamond saw or the like is used to cut a slice from a bar made of lanthanum hexaboride. The diamond saw is then used to cut the slice into the shape of a loop which may be generally rectangular, U-shaped, hairpin-shaped, zigzag-shaped, or generally circular. The filaments provide high electron emission at a relatively low operating temperature, such as 1600.degree. C. To achieve uniform heating, the filament is formed with a cross section which is tapered between the opposite ends of the filament to compensate for non-uniform current distribution along the filament due to the emission of electrons from the filament.
APPLICATION OF FAST TRACKING TECHNIQUES TO OVERCOME TIME & COST OVERRUNS IN CONSTRUCTION (2017)

Construction technology includes a nice potential to enhance productivity and reduce project period. Delay happens in several construction activities, delays will cause wide negative effects like loss of productivity and revenue, and contract termination. Additionally, the paper presents the connection between new technology and time overrun in those projects. In India the amount of road development activities is increasing from time to time. However, it becomes tough to finish the project within the allotted cost and time. Taking this into thought, time and price overrun is one among the most important issues in Indian road project. The foremost necessary causes for overrun were delayed to furnish and deliver the location, financial issues, and improper designing. Whereas the foremost necessary causes of cost overrun were found to be a delay in construction, inadequate provision of raw materials and Instruments by contractors, improper planning, incomplete design. Therefore, this analysis was administered to know such issues and to resolve such overrun of time and cost by implementing fast tracking techniques. Fast tracking is one of project management methodology. It has a very important use and purpose - to deliver on time, on budget activities even once one or additional limiting constraints substitute the method of success. Fast tracking could be a specialized management approach - to be used whenever you’re asked to deliver over existing capabilities enable and you would like a regular way to place things back in balance.
ONE-WAY FUNCTIONS IN REVERSIBLE COMPUTATIONS (1997)

One-way functions are used in modern crypto-systems as doortraps because their inverse functions are supposed to be difficult to compute. Nonetheless with the discovery of reversible computation, it seems that one may break a one-way function by running a reversible computer backward. Here, we argue that reversible computation alone poses no threat to the existence of one-way functions because of the generation of “garbage bits” during computations. Consequently, we prove a necessary and sufficient condition for a one-to-one function to be one-way in terms of the growth rate of the total number of possible garbage bit configurations with the input size.