gebhart/patrepeval huggingface dataset:
Alkylation of Benzene and Homologs with Methylcyclohexenes1 (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation of Benzene and Homologs with Methylcyclohexenes1B. S. Friedman, F. L. Morritz, and C. J. MorrisseyCite this: J. Am. Chem. Soc. 1957, 79, 6, 1465–1468Publication Date (Print):March 1, 1957Publication History Published online1 May 2002Published inissue 1 March 1957https://pubs.acs.org/doi/10.1021/ja01563a052https://doi.org/10.1021/ja01563a052research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Peri-procedural management, implantation feasibility, and short-term outcomes in patients undergoing implantation of leadless pacemakers: European Snapshot Survey (2020)

The aim of this European Heart Rhythm Association (EHRA) prospective snapshot survey is to assess procedural settings, safety measures, and short-term outcomes associated with implantation of leadless pacemakers (LLPM), across a broad range of tertiary European electrophysiology centres. An internet-based electronic questionnaire (30 questions) concerning implantation settings, peri-procedural routines, complications, and in-hospital patient outcomes was circulated to centres routinely implanting both LLPMs and transvenous pacemakers (TV-PM). The centres were requested to prospectively include consecutive patients implanted with either LLPMs or TV-PMs during the 10-week enrolment period. Overall, 21 centres from four countries enrolled 825 consecutive patients between November 2018 and January 2019, including 69 (9%) implanted with LLPMs. Leadless pacemakers were implanted mainly under local anaesthesia (69%), by an electrophysiologist (60%), in the electrophysiology laboratory (71%); 95% of patients received prophylactic antibiotics prior to implantation. Most patients on chronic oral anticoagulation were operated on-drug (35%), or during short-term (to 48 h) drug withdrawal (54%). Implantation was successful in 98% of patients and the only in-hospital procedure-related complication was groyne haematoma in one patient. This EHRA snapshot survey provides important insights into LLPM implantation routines and patient outcomes. These findings suggest that despite the unfavourable clinical profile of pacemaker recipients, LLPM implantation is associated with relatively low risk of complications and good short-term outcomes.
Association Among ICU Congestion, ICU Admission Decision, and Patient Outcomes* (2016)

High ICU congestion is associated with a lower likelihood of ICU admission, which has important operational implications and can affect patient outcomes. By taking advantage of our ability to identify a subset of patients whose ICU admission decisions are affected by congestion, we found that, if congestion were not a barrier and more eligible patients were admitted to ICU, this hospital system could save approximately 7.5 hospital readmissions and 253.8 hospital days per year. These findings could help inform future capacity planning and staffing decisions.
Design of analog circuits using organic field-effect transistors (2010)

Organic field-effect transistors (OFETs) can be manufactured at low temperatures, enabling the fabrication of integrated circuits on flexible plastic substrates and the coverage of large areas at potentially low cost. This paper evaluates state-of-the-art OFET technology from the perspective of the analog circuit designer. Specifically, we review important OFET device performance metrics in comparison to generic silicon CMOS transistors. In addition, an overview of recent accomplishments in OFET-based analog design is presented.
Diagrammatization of Codon Usage in 339 Human Immunodeficiency Virus Proteins and Its Biological Implication (1992)

The occurrence frequencies of bases A (adenine), C (cytosine, G (guanine), and T (thymine) occurring in the 1st, 2nd, and 3rd codon positions in the codon usage table of viral genes for the 339 human immunodeficiency virus (HIV) proteins compiled recently have been calculated and diagrammatized. For comparison, the corresponding diagrammatic representations for the 2681 human proteins from the codon usage table for primate genes are also presented. The analyzed results based on these characteristic diagrams indicate that considerably similar features have been found between HIV and human proteins for the 1st and 2nd codon positions; i.e., they are all occupied predominantly by purine, especially base A. However, a significant difference in the 3rd codon position between HIV and human proteins has been observed; i.e., human proteins are of high C + G content and low A + G content in the 3rd codon position, whereas the case is just the opposite for HIV proteins. The biological implication of such a duality on the codon bias of HIV against human proteins is discussed. It is suggested that the 1st and 2nd codon positions can be termed as the structure-determining position, and the 3rd codon position termed as the species-determining position. The diagrammatic representation and analysis method described here possess a great potential for the study of molecular evolution from the viewpoint of the genetic code for which data have been accumulated rapidly and will continue to grow at a much faster pace.
Convergence and Divergence of Exercise-Based Approaches That Incorporate Motor Control for the Management of Low Back Pain (2019)

Many approaches for low back pain (LBP) management focus on modifying motor control, which refers to motor, sensory, and central processes for control of posture and movement. A common assumption across approaches is that the way an individual loads the spine by typical postures, movements, and muscle activation strategies contributes to LBP symptom onset, persistence, and recovery. However, there are also divergent features from one approach to another. This commentary presents key principles of 4 clinical physical therapy approaches, including how each incorporates motor control in LBP management, the convergence and divergence of these approaches, and how they interface with medical LBP management. The approaches considered are movement system impairment syndromes of the lumbar spine, Mechanical Diagnosis and Therapy, motor control training, and the integrated systems model. These were selected to represent the diversity of applications, including approaches using motor control as a central or an adjunct feature, and approaches that are evidence based or evidence informed. This identification of areas of convergence and divergence of approaches is designed to clarify the key aspects of each approach and thereby serve as a guide for the clinician and to provide a platform for considering a hybrid approach tailored to the individual patient. <i>J Orthop Sports Phys Ther 2019;49(6):437-452. Epub 15 May 2019. doi:10.2519/jospt.2019.8451</i>.
Do healthier foods and diet patterns cost more than less healthy options? A systematic review and meta-analysis (2013)

This meta-analysis provides the best evidence until today of price differences of healthier vs less healthy foods/diet patterns, highlighting the challenges and opportunities for reducing financial barriers to healthy eating.
Effect of the rehydration medium on the recovery of freeze-dried lactic acid bacteria (1985)

Sixteen cultures of lactic acid bacteria were freeze-dried in 10% nonfat skim milk plus 0.75 M adonitol and rehydrated by using different rehydration media. Marked variations in their capacity to repair cellular damage after freeze-drying were observed among the species and strains under consideration.
Construction of Chemical‐Responsive Supramolecular Hydrogels from Guest‐Modified Cyclodextrins (2008)

A methodology for preparing supramolecular hydrogels from guest-modified cyclodextrins (CDs) based on the host-guest and hydrogen-bonding interactions of CDs is presented. Four types of modified CDs were synthesized to understand better the gelation mechanism. The 2D ROESY NMR spectrum of beta-CD-AmTNB (Am=amino, TNB=trinitrobenzene) reveals that the TNB group was included in the beta-CD cavity. Pulsed field gradient NMR (PFG NMR) spectroscopy and AFM show that beta-CD-AmTNB formed a supramolecular polymer in aqueous solution through head-to-tail stacking. Although beta-CD-AmTNB did not produce a hydrogel due to insufficient growth of supramolecular polymers, beta-CD-CiAmTNB (Ci=cinnamoyl) formed supramolecular fibrils through host-guest interactions. Hydrogen bonds between the cross-linked fibrils resulted in the hydrogel, which displayed excellent chemical-responsive properties. Gel-to-sol transitions occurred by adding 1-adamantane carboxylic acid (AdCA) or urea. (1)H NMR and induced circular dichroism (ICD) spectra reveal that AdCA released the guest parts from the CD cavity and that urea acts as a denaturing agent to break the hydrogen bonds between CDs. The hydrogel was also destroyed by adding beta-CD, which acts as the competitive host to reduce the fibrils. Furthermore, the gel changed to a sol by adding methyl orange (MO) as a guest compound, but the gel reappeared upon addition of alpha-CD, which is a stronger host for MO.
Anions of Buckybowls (2011)

This chapter contains sections titled: Introduction Reduction of Corannulene and Substituted Corannulenes Anions of Annelated Corannulenes Diindenochrysene Anions Sumanene Trianion Hemifullerene Summary References
Industrial Applications of the Diels–Alder Reaction (2013)

The Diels-Alder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large-scale applications (>1 kg) from a process research and development perspective.
Improved silicon photovoltaic cells (1959)

A worn-out mental model of the nursing profession may be holding it back.
Hazard analysis critical control point evaluations : a guide to identifying hazards and assessing risks associated with food preparation and storage (1992)

Hazard analysis critical control point evaluations: a guide to identifying hazards and assessing risks associated with food preparation and storage , Hazard analysis critical control point evaluations: a guide to identifying hazards and assessing ris... , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Severe chronic constipation of young women: 'idiopathic slow transit constipation'. (1986)

A series of 64 women complaining of severe constipation is described, in each of whom delayed elimination of markers from the colon was demonstrated but a barium enema was normal. All completed a detailed questionnaire and the responses are compared with those obtained in an age-matched series of healthy women with no bowel complaint. In each group 40 women also recorded in a manner suitable for analysis all food eaten over a period of seven days. The patients passed about one stool weekly with the aid of laxatives, and were greatly troubled by abdominal pain, bloating, malaise and nausea, to the extent that the symptoms were a major social disability and many lost time from work. Decreased bowel frequency and other symptoms were often first noticed around the age of puberty and slowly became worse until they were severe by the third decade. In a few, the symptoms began suddenly after an abdominal operation c-accident. Comparison with the control group showed no evidence that the patients had been underweight at any time or that they took less fibre; treatment with a bran supplement did not usually help them. The patients experienced rectal sensation before defaecation less often than the control subjects and they used digital pressure to assist defaecation more frequently. The women with constipation tended to have more painful and irregular menstrual periods, and there was an increased incidence of ovarian cystectomy and hysterectomy. Hesitancy in starting to pass urine was more common, as were some somatic symptoms such as cold hands or blackouts. Attention is drawn to this distinctive combination in young women of slow total gut transit time and a colon of normal width on barium enema, associated with abdominal, anorectal, gynaecological and somatic symptoms, as a disorder which can be disabling and particularly difficult to treat.
Inhibition of PI3K/AKT/mTOR Pathway Enhances Temozolomide-Induced Cytotoxicity in Pituitary Adenoma Cell Lines in Vitro and Xenografted Pituitary Adenoma in Female Nude Mice (2013)

Invasive pituitary adenomas (PAs) are often refractory to standard therapy and salvage treatment with temozolomide (TMZ). Hyperactivation of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway contributes to chemotherapy resistance in many cancers. XL765, a novel dual-PI3K/mTOR inhibitor, has recently shown its efficacy as a monotherapy and in combination with conventional therapeutics in many cancers. The hyperactive PI3K/AKT/mTOR pathway frequently occurs in invasive PAs. In this study, we investigated whether XL765 sensitizes PA cells to TMZ in vitro and in vivo. Experiments were carried out to evaluate the effect of XL765 and TMZ alone or in combination on cell proliferation and apoptosis of PA cell lines (αT3-1, GH3, and MMQ) in vitro as well as the tumor growth and serum GH and prolactin secretions in a GH3 xenograft tumor model of female nude mice. XL765 and TMZ synergistically inhibited the growth of PA cell lines and induced apoptosis. Combination of XL765 and TMZ synergistically inhibited tumor growth, decreased serum GH and prolactin levels, and reduced the sacrifice rate of GH3 xenograft tumor models without increased systemic side effects. In addition, XL765 in combination with TMZ dramatically decreased phosphorylation of AKT and mTOR as well as the expression of Bcl-2. The increased expression of cleaved poly (ADP-ribose) polymerase and Bcl-2-associated X protein along with elevated caspase-3/7 activity were also observed in the combination group. Therefore, dual inhibitors of PI3K and mTOR may enhance alkylating agent-mediated cytotoxicity and provide a novel regimen in the treatment of invasive PAs.
Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines (2007)

IL-1 beta disrupts cholesterol-mediated LDL receptor feedback regulation by enhancing SCAP-SREBP complex translocation from the ER to the Golgi, thereby increasing SREBP-2 mediated LDL receptor expression even in the presence of high concentration of LDL. This results in LDL cholesterol accumulation in hepatic cells via LDL receptor pathway under inflammatory stress.
Conceptualizing Ideation Workshops for SMEs (2015)

An external ideation space seems to be a promising way to support SMEs in ideating new products and services. This paper addresses the question ‘how to operationalize important working principles in the fuzzy front end of product development for ideation workshops with SMEs, aiming at ideating new products and services?’ Based on the principles of user-centred design, iterative prototyping, as well as the SMEs’ need to take home the workshop outcome, we propose an ideation workshop concept, apply the concept in four workshops with different companies, and analyse it by triangulation of protocols, recordings, and interviews with the SMEs’ CEOs.
Cardiac screening in congenital spine disorders. (2007)

The presentation of congenital heart disease associated with congenital spine disorders is general clinically evident and made before the referral to the orthopaedist. Routine referral by the orthopaedist for ECG or echocardiogram is not supported by this work.
Transformation (2018)

To describe a representation of the transformation of institutions, the chapter leans on a biological metaphor, while remaining cautious with the use of such a process. A biological metaphor, while proving to be a useful framework in the demonstration, still remains somewhat limited. The chapter attempts to overcome those limits by drawing on the political and psychic dimensions of these processes, making links to the role that managers and consultants can take up in these transformations. Phases of progression and regression become better identified and it becomes possible to encourage progressions and to admit that regressions are often necessary for future progressions. The zig-zag trajectory of transformation and the other marks of resistance, affects, guilt, anxiety, and the mystery and opacity of the breakthrough, are so many manifestations of the part of chaos contained in the process.
Development of 1MW output power level gyrotron for ITER ECRH system (1999)

The paper presents the approach and results of development of the 170 GHz/1 MW ITER gyrotron in Russia. The main problems of elaborating powerful gyrotrons are discussed. Results of 170 GHz gyrotron tests are analyzed and compared with the theory. ITER related 110 GHz and 140 GHz gyrotrons are also investigated. The possibility to create a 170 GHz/1 MW gyrotron for ITER is proved by calculations and experiments. (author)
Understanding sexual and reproductive health needs of adolescents: Evidence formative study in three districts of lake regions in Tanzania (2021)

Abstract Background Teenage marriage and adolescent pregnancy present a significant health challenge in the Tanzania. About 36% of women aged 15-49 are married before the age of 18, and 32% of rural adolescents (10-19 years) gave birth, compared with 19% of urban. In Mwanza region, one third of currently married adolescent and women aged 15-49 experienced unmet need for family planning and had low use of modern contraceptives. Here we present a study that explored the gaps in accessing and utilization of quality adolescent sexual and reproductive health services (ASRH). Methods This was a descriptive and exploratory cross-sectional formative study utilizing multiple qualitative research methods. Purposive sampling was used to select an urban district (Nyamagana), rural district (Magu) and an island (Ukerewe). Sixty-seven IDI and 30 focus group discussions (FGDs) stratified by gender (12 out-of-school, 12 in-school), and (3 male, 3 female adults) were purposefully sampled. Vignettes were done with 15-19 years old in-school and out-of-schools boys and girls. An experienced moderator, along with a note-taker, led the discussions while taking notes. The FGDs were recorded using an MP3 voice recorder. Thematic analysis approach was undertaken and data was analysed using NVivo 12, a qualitative software. Results The identified the most important pressing needs of the adolescents in relation to SRH. Adolescent girls needed specific services such as counselling on menstrual health, sexual consent, HIV/AIDS, and prevention of pregnancies. Sanitary pads during menstrual period were very important pressing need of the adolescent girls. Adolescents both girls and boys preferred to receiving friendly health care services in a respectful manner. Girls mentioned that they would like to receive SRH support from nurses in health facilities, mothers, sisters, aunties and friends. With regards to boys, they preferred to receive the SRH from health care providers followed with their peer’s friends. Several obstacles were reported to hinder access to SRHS predominantly among the adolescent girls as compared to the boys. Poor infrastructure tended to impair the privacy at the health facilities, and rarely there were specific buildings to provide friendly adolescent sexual and reproductive health services. Conclusions The strategies to guide delivery of ASRH should involve the inclusion of duty bearers, promotion of friendly health care services where health workers provide services in friendly-manner, provision of ASRH education for awareness creation to adolescents and supportive parents/ care takers.
Predictors of Postoperative Acute Renal Failure after Noncardiac Surgery in Patients with Previously Normal Renal Function (2007)

Several preoperative predictors previously reported to be associated with acute renal failure after cardiac surgery were also found to be associated with acute renal failure after noncardiac surgery. The use of vasopressor and diuretics is also associated with acute renal failure.
Biliary Dyskinesia: Mechanisms and Management (1982)

Biliary colic in the absence of demonstrable stones--and, indeed, in the absence of a gallbladder--has long been mystifying. Evidence is growing for the existence of purely functional disease of the biliary system. Although the mechanisms have not been fully elucidated, investigative procedures seem to provide a clinical basis for the diagnosis of biliary dyskinesia.
ChemInform Abstract: Active/Inactive Nanocomposites as Anodes for Li‐Ion Batteries. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
State-of-the-Art 800G/1.6T Datacom Interconnects and Outlook for 3.2T (2023)

We review state-of-the-art datacenter technologies for 800G, 1.6T and beyond interconnect speeds, focusing on 200G per-lane IM-DD (intensity modulated-direct detect) and 800G-LR1 coherent-lite transmissions.