gebhart/patrepeval huggingface dataset:
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance (2011)

Although human cancers have complex genotypes and are genomically unstable, they often remain dependent on the continued presence of single-driver mutations-a phenomenon dubbed "oncogene addiction." Such dependencies have been demonstrated in mouse models, where conditional expression systems have revealed that oncogenes able to initiate cancer are often required for tumor maintenance and progression, thus validating the pathways they control as therapeutic targets. Here, we implement an integrative approach that combines genetically defined mouse models, transcriptional profiling, and a novel inducible RNAi platform to characterize cellular programs that underlie addiction to MLL-AF9-a fusion oncoprotein involved in aggressive forms of acute myeloid leukemia (AML). We show that MLL-AF9 contributes to leukemia maintenance by enforcing a Myb-coordinated program of aberrant self-renewal involving genes linked to leukemia stem cell potential and poor prognosis in human AML. Accordingly, partial and transient Myb suppression precisely phenocopies MLL-AF9 withdrawal and eradicates aggressive AML in vivo without preventing normal myelopoiesis, indicating that strategies to inhibit Myb-dependent aberrant self-renewal programs hold promise as effective and cancer-specific therapeutics. Together, our results identify Myb as a critical mediator of oncogene addiction in AML, delineate relevant Myb target genes that are amenable to pharmacologic inhibition, and establish a general approach for dissecting oncogene addiction in vivo.
Dosimetric accuracy of the ITP™ inverse treatment planning system (2002)

The dosimetric accuracy of the ITP system for intensity modulated radiation therapy was determined for 19 patient plans. Treatments were given with a Varian 2100C and a 120-leaf multileaf collimator using step and shoot delivery. Both absolute dose, determined by an ionization chamber, and relative dose, determined by film, were assessed. It was found that absolute dose agreement was within 0.1% +/- 1.5%, isodoses in the high dose-low gradient region were within 1.7% +/- 2%, and the distance to agreement for isodoses between 20% and 90% was 1.4 mm +/- 1 mm. This agreement is at least as good as that found for standard wedged fields in most treatment planning systems.
Prostate‐specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy (2008)

LOH is an increasingly prevalent disease characterized by a symptomatically low testosterone level, and TRT is effective in normalizing serum testosterone levels, providing a beneficial cardiovascular effect, and improving sexual function and overall quality of life. PSA levels remain stable after normalization of testosterone for > or =5 years, prostate cancer can be effectively diagnosed and treated in men taking TRT, and the incidence of prostate cancer among men with LOH on TRT is no greater than that in the general population.
The importance of different frequency bands to the speech perception of cochlear implantees [Abstract] (1996)

Paper presented at the 12th National Conference of the Audiological Society of Australia. Brisbane, 29 April - 2 May 1996.
Knowledge, behaviour and attitudes towards Chagas disease among the Bolivian migrant population living in Japan: a cross-sectional study (2020)

EA with an integrative approach is useful to increase the knowledge of CD within the Bolivian migrant population living in Japan. The activity brings the possibility to explore not only the level of knowledge but also to reveal experiences and to understand the needs of the people at risk. Considering them as actors towards healthcare solutions could lead to better outcomes for the success of future policies and interventions aimed to decrease the global burden.
Transparent threads: resource sharing in SMT processors for high single-thread performance (2003)

To realize transparent threads, we propose three mechanisms for maintaining the transparency of background threads: slot prioritization, background thread instruction-window partitioning, and background thread flushing. In addition, we propose three mechanisms to boost background thread performance without sacrificing transparency: aggressive fetch partitioning, foreground thread instruction-window partitioning, and foreground thread flushing. We implement our mechanisms on a detailed simulator of an SMT processor and evaluate them using 8 benchmarks, including 7 from the SPEC CPU2000 suite. Our results show when cache and branch predictor interference are factored out, background threads introduce less than 1% performance degradation on the foreground thread Furthermore, maintaining the transparency of background threads reduces their throughput by only 23% relative to an equal priority scheme. To demonstrate the usefulness of transparent threads, we study transparent software prefetching (TSP), an implementation of software data prefetching using transparent threads. Due to its near-zero overhead, TSP enables prefetch instrumentation for all loads in a program, eliminating the need for profiling. TSP without any profile information, achieves a 9.52% gain across 6 SPEC benchmarks, whereas conventional software prefetching guided by cache-miss profiles increases performance by only 2.47%.
Sulfur K-Edge X-ray Absorption Spectroscopy of Aryl and Aryl–Alkyl Sulfides (2019)

Aryl and mixed aryl-alkyl organic sulfides are important species in a variety of fields, including the drug and food industries. They also are present in fossil fuels, where they contribute to the range of sulfur compounds that must be removed by the fuel industry. We have used sulfur K-edge X-ray absorption spectroscopy, in combination with density functional theory calculations, to study the aryl sulfide diphenyl sulfide and two different aryl-alkyl sulfides. The sulfur K near-edge X-ray absorption spectra are strongly affected by the coordination of the phenyl ring and are distinct from spectra of the alkyl sulfides. For diphenyl sulfide the spectra are predicted to be sensitive to rotation about the S-C bonds, with experimental spectra corresponding to a sum of thermally accessible conformations. We also have investigated the vapor-phase spectrum of diphenyl sulfide, which is found to be very similar to that of toluene solutions of the compound.
Electrical Injury in the Femoral Artery of Rabbits as a Model for Arterial Thrombosis: A Pilot Study (1994)

Electrical stimulation was delivered to the femoral artery of 20 rabbits to examine whether endothelial injury results in a consistent formation of arterial thrombosis. The arterial patency was monitored throughout the experiment by flowmeter and was visualized by femoral angiography in 5/20 cases. The arterial segments remained totally occluded in 7/20 (35%), partially occluded in 9/20 (45%), and patent in 4/20 (20%) rabbits following stimulation with 200 microA anodal current for 180 minutes. The average time of electrical stimulation needed to achieve total occlusion (n = 7) was 110 +/- 49 minutes. Alternating occlusion and recanalization of the artery (cyclic flow variation) was observed in 12 rabbits, with total occlusion ensuing in 6/12 cases. Intravenous administration of recombinant tissue-type plasminogen activator (20 micrograms/kg/min for sixty minutes) resulted in femoral reflow and subsequent reocclusion in 2/5 cases. Histopathologic examination disclosed arterial thrombi composed of platelets, fibrin, and red blood cells. Thus, according to these data this technique was found to induce arterial thrombosis following electrical stimulation of the rabbit femoral artery but was inconsistent regarding the arterial patency.
Quantum-mechanical modeling of electron tunneling current from the inversion layer of ultra-thin-oxide nMOSFET's (1997)

Quantum-mechanical modeling of electron tunneling current from the quantized inversion layer of ultra-thin-oxide (<40 /spl Aring/) nMOSFET's is presented, together with experimental verification. An accurate determination of the physical oxide thickness is achieved by fitting experimentally measured capacitance-versus-voltage curves to quantum-mechanically simulated capacitance-versus-voltage results. The lifetimes of quasibound states and the direct tunneling current are calculated using a transverse-resonant method. These results are used to project an oxide scaling limit of 20 /spl Aring/ before the chip standby power becomes excessive due to tunneling currents,.
The physiologic response to isoproterenol during hypothermia and rewarming (2007)

Our purpose was to determine both if hypothermia has any effects on physiological hemodynamic response to isoproterenol (Iso) and if rewarming reverses these effects. Rats were instrumented to measure mean arterial pressure (MAP) and left ventricular (LV) pressure-volume changes using a Millar pressure-volume conductance catheter. Core temperature was manipulated from 37 °C (normothermia) to 24°C (hypothermia) and back to 37°C (rewarming) using both internal and external heat exchangers. During cooling at each temperature (33, 30, 27 and 24°C), central hemodynamic variables and MAP were measured while infusing Iso with the dose of 0.0017, 0.005, 0.01, and 0.02 μg · min-1, respectively. Seven animals underwent all phases of the protocol. At normothermia Iso infusion resulted in a significant, dose-dependent increase in heart rate (HR), stroke volume (SV), cardiac output (CO), LV dP/dtmax but no change in MAP. During cooling Iso infusion caused no significant change in any of the hemodynamic variables. After rewarming basal HR was increased, whereas SV and LV dP/dtmax were both significantly reduced when compared to their prehypothermic basal values, and they were non-responsive to Iso infusion. This study shows that hypothermia caused a change in physiological response to Iso, which was not reversed by rewarming.
The use of an interface anneal to control the base current and emitter resistance of p-n-p polysilicon emitter bipolar transistors (1992)

The effects of an interface anneal on the electrical characteristics of p-n-p polysilicon-emitter bipolar transistors are reported. For devices with a deliberately grown interfacial oxide layer, an interface anneal at 1100 degrees C leads to a factor of 15 increase in base current, and a factor of 2.5 decrease in emitter resistance, compared with an unannealed control device. These results are compared with identical interface anneals performed on n-p-n devices, and it is shown that the increase in base current for p-n-p devices is considerably smaller than that for the n-p-n devices. This result is explained by the presence of fluorine in the p-n-p devices, which accelerates the breakup of the interfacial layer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Timing of Decremental Response During Repetitive Nerve Stimulation in Myasthenia Gravis (2022)

Background: A decrement &gt;10% detected during repetitive nerve stimulation (RNS) is supportive of considering a diagnosis of myasthenia gravis (MG). Several studies have found that most of this decrement is seen between 4 to 6 min post-exercise. However, there are not available studies analyzing if shorter timing would be sufficient. &#x0D; Objective: The objective of this study was to evaluate if RNS up to 2 min post-exercise is sufficient to detect a decrement response &gt;10%.&#x0D; Methods: We performed a retrospective chart review study of patients referred to our neuromuscular clinic at The University of Kansas Medical Center with symptoms suggestive of MG from 2013 to 2017.&#x0D; Results: A total of 76 patients with MG and 100 controls were identified. A significant decrement was detected in 95% of MG patients with abnormal RNS within 2 minutes post-exercise.&#x0D; Conclusion: RNS up to 2 min post-exercise might be sufficient to detect a significant decrement in MG patients.
Insights from Computational Studies on d 0 Metal‐Catalyzed Alkene and Alkyne Metathesis and Related Reactions (2015)

The computational studies (essentially by DFT methods) of alkene (olefin), and alkyne metathesis by d0 transition metal alkylidene or alkylidyne catalysts are described. The scope of the review includes molecular catalysts (Mo, W, Re), well-defined catalysts (Mo, W, Re, Ta) supported on oxides (silica, alumina) and also heterogeneous catalysts (MoO3, Re2O7 and related) on supports (zeolites, alumina silica:alumina), but also the related nitrile-alkyne cross metathesis and alkane metathesis reactions. Besides structural information about active sites/species, the review describes the reaction pathways of metathesis reaction as well as those leading to catalyst deactivation and side products formation. The influence of the metal and ligands on the energy profiles via a detailed description of transition states and intermediates and the relationship between computational and experimental studies are central aspects of this chapter. The methods used in the studies (molecular, cluster or periodic models, QM vs. QM-MM) are mentioned to present how the models account for the diversity of experimental conditions. While the analogies and differences between the pathways for the various catalysts are discussed, the classical Chauvin mechanism appears general, even if additional steps need to be considered for full description of the pathways and for the understanding of structure — reactivity relationship for d0 alkene metathesis catalysts.
Alzheimer Abnormalities of the Amygdala With Klüver-Bucy Syndrome Symptoms (2009)

This case represents a variant of Alzheimer disease with prominent amygdala abnormalities and a Klüver-Bucy phenotype that was misdiagnosed as frontotemporal dementia. Clinical and imaging findings that may aid in accurate diagnosis are reviewed.
A randomized, double-blind, placebo-controlled study of the lowest effective dose of drospirenone with 17β-estradiol for moderate to severe vasomotor symptoms in postmenopausal women (2013)

Drospirenone 0.25 mg/17β-estradiol 0.5 mg is concluded to be the lowest dose with demonstrated efficacy in the treatment of postmenopausal women with moderate to severe vasomotor symptoms.
Dysplasia in Fundic Gland Polyps is Associated with Nuclear β-Catenin Expression and Relatively High Cell Turnover Rates (2003)

The finding of similar rates of proliferation and apoptosis in syndromic and sporadic FGPs does not support the hypothesis that APC and beta-catenin gene mutations have different functional consequences in FGPs. The association of dysplasia with relatively high cell turnover rates and nuclear expression of beta-catenin indicates activation of the Wnt-APC-beta-catenin pathway in dysplasia. The finding of dysplasia in some but not all syndromic FGPs suggests the involvement of other genes in addition to the APC gene in the development of dysplasia in FGPs.
SELANGKAH KEARAH KELESTARIAN GLOBAL KEUSAHAWANAN NEGERI JOHOR (2020)

Buku ini membincangkan tentang hala tuju keusahawanan global bagi mengekalkan kelestarian Industri Kecil Sederhana (IKS) di negeri Johor di samping memberi nafas baharu dalam membangunkan perusahaan yang berpotensi tinggi seperti hasil pertanian, penternakan dan perikanan. Model pendekatan dimensi yang digunakan adalah model triple helix melalui inisiatif Institut Inovasi Strategik Johor (IISJ) atau kini dikenali sebagai Johor Innovation Valley (JIVe). Buku yang mengandungi 10 bab ini mengupas isu-isu dan cabaran untuk mengekalkan kelestarian keusahawanan IKS sebagai hab sekuriti makanan, keperluan latihan yang komprehensif, dan juga pengenalan teknologi dan teknik terbaharu untuk meningkatkan hasil pertanian dan penternakan. Selain itu, buku ini juga menggarap peluang dan kaedah bagi memperkasa jaringan revolusi industri halal selain memberi pendedahan mengenai penggunaan platform digital sebagai kaedah jual beli, penjenamaan dan pemasaran produk halal paling efektif di peringkat global. Buku ini amat sesuai dijadikan rujukan buat semua golongan usahawan IKS yang ingin mengetahui cara mengubah kaedah perusahaan konvesional kepada penggunaan inovasi baharu yang lebih cekap dan berteknologi tinggi untuk produk dan perkhidmatan mereka, berpaksikan libatsama kepakaran Universiti, sokongan kerajaan negeri, dan juga penglibatan industri dalam pemerkasaan ekonomi masyarakat itu sendiri.
beta-Lapachona: Sua Importância em Química Medicinal e Modificações Estruturais (2010)

Esta mini-revisao descreve o trabalho de pesquisadores brasileiros que iniciaram a pesquisa com o lapachol e a beta-lapachona, produtos naturais inspiradores de uma serie de trabalhos cientificos sobre novas substâncias com atividade anti-câncer, tripanocida, anti-inflamatoria, tuberculostatica e anti-malarial . Entre estas pesquisas, sao apresentadas algumas das mais importantes modificacoes estruturais realizadas nas funcoes carbonilicas destas naftoquinonas, apresentando os principais resultados obtidos no âmbito da quimica medicinal. DOI: 10.5935/1984-6835.20100013
Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy (2021)

Magneto-plasmonic nanocomposites can possess properties inherent to both individual components (iron oxide and gold nanoparticles) and are reported to demonstrate high potential in targeted drug delivery and therapy. Herein, we report on Fe<sub>3</sub>O<sub>4</sub>/Au magneto-plasmonic nanocomposites (MPNC) synthesized with the use of amino acid tryptophan via chemical and photochemical reduction of Au ions in the presence of nanosized magnetite. The magnetic field (MF) induced aggregation was accompanied by an increase in the absorption in the near-infrared (NIR) spectral region, which was demonstrated to provide an enhanced photothermal (PT) effect under NIR laser irradiation (at 808 nm). A possibility for therapeutic application of the MPNC was illustrated using cancer cells in vitro. Cultured HeLa cells were treated by MPNC in the presence of MF and without it, following laser irradiation and imaging using confocal laser scanning microscopy. After scanning laser irradiation of the MPNC/MF treated cells, a formation and rise of photothermally-induced microbubbles on the cell surfaces was observed, leading to a damage of the cell membrane and cell destruction. We conclude that the synthesized magneto-plasmonic Fe<sub>3</sub>O<sub>4</sub>/Au nanosystems exhibit magnetic field-induced reversible aggregation accompanied by an increase in NIR absorption, allowing for an opportunity to magnetophoretically control and locally enhance a NIR light-induced thermal effect, which holds high promise for the application in photothermal therapy.
Laser microdissection of metaphase chromosomes and characterization by atomic force microscopy (1997)

A new experimental setup has been constructed in which a UV laser microbeam and atomic force microscopy (AFM) have been combined on an inverted microscope in order to manipulate and visualize chromosomes with high resolution. The laser beam has been used to dissect Muntjak metaphase chromosomes and was aimed to optimize the physical size of the cuts. The capability of the AFM to visualize biological material with relative ease has been used to characterize the microdissected chromosomes. This work demonstrates that chromosome fiber material can be removed completely at the cut site using appropriate laser power. The minimum cut size achieved with a 337-nm nitrogen UV laser was between 600 and 800 nm. The smallest distance between the cuts was around 500 nm, corresponding to the finest probe for further biochemical use after physical translocation such as the polymerase chain reaction. Limitations on minimizing the cut size due to diffraction-limited focusing and the effects of laser ablation of biomaterial are discussed.
Microfabrication of Thermoelectric Hydrogen Sensor Using KOH Solution Etching (2006)

Micromachined sensors are a new generation of sensor technology combining existing integrated circuit fabrication technology with novel deposition and etching processing. In the viewpoint of low-power operation, high sensitivity and fast response speed of thermoelectric hydrogen sensor (THS), we prepared the micromachined thermoelectric hydrogen sensor (micro-THS) with the combination of the thermoelectric effect of SiGe thin film and the Pt-catalyzed exothermic reaction of hydrogen oxidation. The power consumption of the micro-THS was greatly reduced to be 50 mW for 100 °C operating, by the Pt-micro-heater on single membrane. The micro-THS with 40 wt.% Pt/alumina catalyst showed voltage signal of 10 mV for 1 % H2 in air.
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver (2005)

Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the risk of rAAV integration because integration occurs preferentially in genes and accompanies chromosomal deletions, which may lead to loss-of-function insertional mutagenesis. Here, by analyzing 347 rAAV integrations in mice, we elucidate novel features of rAAV integration: the presence of hot spots for integration and a strong preference for integrating near gene regulatory sequences. The most prominent hot spot was a harmless chromosomal niche in the rRNA gene repeats, whereas nearly half of the integrations landed near transcription start sites or CpG islands, suggesting the possibility of activating flanking cellular disease genes by vector integration, similar to retroviral gain-of-function insertional mutagenesis. Possible cancer-related genes were hit by rAAV integration at a frequency of 3.5%. In addition, the information about chromosomal changes at 218 integration sites and 602 breakpoints of vector genomes have provided a clue to how vector terminal repeats and host chromosomal DNA are joined in the integration process. Thus, the present study provides new insights into the risk of rAAV-mediated insertional mutagenesis and the mechanisms of rAAV integration.
Directed evolution of β‐galactosidase from Escherichia coli by mutator strains defective in the 3′→5′ exonuclease activity of DNA polymerase III (2001)

Directed evolution of Escherichia coli beta-galactosidase into variants featuring beta-glucosidase activity was challenged. To this end, mutagenesis of lacZ was performed by replication in E. coli CC954, a mutator strain containing a DNA polymerase III defective in 3'-->5' exonuclease activity. beta-Galactosidase variants can be isolated upon mutagenesis of lacZ hosted into the self-transmissible episome F'128. Optimal evolution of lacZ can be achieved by propagation of E. coli CC954/F'128 cultures for 15 generations; further growth of mutator cultures for 37 or 55 generations imposes a high mutational load on lacZ and hinders the selection of efficiently evolved clones.
Condition Monitoring of Industrial Electric Machines: State of the Art and Future Challenges (2020)

The limitations of the thermal, vibration, or electrical monitoring of electric machines such as false indications, low sensitivity, and difficulty of fault interpretation have recently been exposed. This has led to a shift in the direction in research toward applying new techniques for improving the reliability of condition monitoring. With the changing environment, the purpose of this article is to provide an overview of the recent trends in the industrial demand and research activity in condition monitoring technology. The new developments in insulation testing, electrical testing, flux analysis, transient analysis, and fault prognostics are summarized. The challenges and recommendations for future work for the new technologies are also explored to help support target research and development efforts according to industrial needs.