gebhart/patrepeval huggingface dataset:
Use of a Novel Panel of Nine Short Tandem Repeats for Exact and High-Resolution Fingerprinting of Aspergillus fumigatus Isolates (2005)

Here we describe a new panel of short tandem repeats (STRs) for a novel exact typing assay that can be used to discriminate between Aspergillus fumigatus isolates. A total of nine STR markers were selected from available genomic A. fumigatus sequences and were divided into three multicolor multiplex PCRs. Each multiplex reaction amplified three di-, tri-, or tetranucleotide repeats, respectively. All nine STR markers were used to analyze 100 presumably unrelated A. fumigatus isolates. For each marker, between 11 and 37 alleles were found in this population. One isolate proved to be a mixture of at least two different isolates. With the remaining 99 isolates, 96 different fingerprinting profiles were obtained. The Simpson's diversity index for the individual markers ranged from 0.77 to 0.97. The diversity index for the multiplex combination of di-, tri-, and tetranucleotide repeats ranged from 0.9784 to 0.9968. The combination of all nine markers yielded a Simpson's diversity index of 0.9994, indicative of the high discriminatory power of these new loci. In theory, this panel of markers is able to discriminate between no less than 27 x 10(9) different genotypes. The multicolor multiplex approach allows large numbers of markers to be tested in a short period of time. The exact nature of the assay combines high reproducibility with the easy exchange of results and makes it a very suitable tool for large-scale epidemiological studies.
An extended precision logarithmic number system (1983)

The logarithmic number system possesses a comparatively wide dynamic range. In order to perform addition to this system, memory table lookup operations are needed. The address space limitations of contemporary high-speed static RAM's or ROM currently limit the admissible logarithmic wordlength. To overcome this problem, a linear interpolation logarithmic arithmetic unit is developed and tested.
Human factors investigation of manual and loadable data comm messages in NextGen (2013)

Honeywell Aerospace performed a research study on behalf of the Federal Aviation Administration's NextGen Human Factors Division to investigate the strengths and weaknesses of manual entry as compared to loadable entry of uplinked clearances into the B-777 flight management system (FMS). Five flight crews flew an experimental scenario with Air Traffic Control (ATC) clearances that included a mix of single uplink messages and concatenated messages. The mean flight crew response time across all conditions was 36.7 seconds without outliers, and 44.5 seconds with outliers. Additionally, 83% of the flight crew responses were received in less than one minute, while 100% percent of their responses were received in less than two minutes. When available, flight crews used the load function (direct loading of a loadable ATC clearance into the FMS) 74% of the time. Flight crew response times for manual versus loadable ATC clearances were not statistically different. The mean response time for concatenated messages was statistically higher than for non-concatenated. Based on the study results, flight deck human machine interface (HMI) recommendations address improvements to (i) the salience of a loadable message; (ii) button logic and menu structure; and (iii) integration of the data communications and FMS interface for clearances containing required times of arrival, including the potential need for flight crew decision support. The study results and recommendations support FAA NextGen operational and certification guidance development by providing information for data communications operational approval considerations, aircraft certification considerations and air traffic operational procedures considerations.
Dihydrochalcone sweeteners. A study of the atypical temporal phenomena (1981)

Neohesperidin dihydrochalcone (NHDHC), known since 1963 as an intensely sweet compound, is determined to be 340 +/- 60 (p less than 0.05) times more potent than sucrose. The unusual temporal properties of this material are hypothesized as being due to the effects of metabolism, conformation, chelation, or hydrophobicity. Forty-four analogues are synthesized to test the four hypotheses, none of which are strongly supported. A method of quantitation of temporal characteristics of tastant molecules is developed so as to allow comparison of taste appearance time (AT) and extinction time (ET) of experimental compounds. Four of the new compounds, 40 and 43-45, exhibit high sweetness potencies, ranging from 280 and 440 times sucrose, and may be useful in selected food systems. The temporal taste characteristics remain unimproved over NHDHC, however.
Secured distributed discovery services in the EPCglobal network (2013)

The EPCglobal Network is a global network developed to ensure global interoperability between trading partners in supply chains. Its main goal consists of providing real-time and accurate traceability of items in the supply chains. One of the major building blocks of the EPCglobal Network is the Object Naming Service (ONS) which is a central lookup service used mainly to locate the EPC manager information sources of a given EPC. Discovery services refer to a suite of services enabling any user, subject to authentication, to retrieve all relevant data, subject to access control policies, related to a given EPC in the EPCglobal Network. Many promising DHT-based distributed and secure architectures have been proposed to make the ONS more scalable and more secure than the current ONS specifications. Some of them focused on improving a specific aspect of the existing ONS architecture while others suggested integrated solutions for various weaknesses of the current ONS system. In this paper, we present a DHT-based, scalable and secure architecture for data lookup in the EPCglobal Network. The proposed architecture aims at replacing the current ONS system with a secure distributed Discovery Services system.
Faculty Opinions recommendation of Involvement of nectin in the localization of junctional adhesion molecule at tight junctions. (2002)

Junctional adhesion molecule (JAM) is a Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at tight junctions (TJs). Claudin is a key cell-cell adhesion molecule that forms TJ strands at TJs. JAM is associated with claudin through their cytoplasmic tail-binding protein, ZO-1. JAM is furthermore associated with Par-3, a cell polarity protein which forms a ternary complex with Par-6 and atypical protein kinase C. Nectin is another Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which localizes at adherens junctions (AJs). Nectin is associated with E-cadherin through their respective cytoplasmic tail-binding proteins, afadin and catenins, and involved in the formation of AJs cooperatively with E-cadherin. We show here that nectin is furthermore involved in the localization of JAM at TJs. During the formation of the junctional complex consisting of AJs and TJs in Madin-Darby canine kidney (MDCK) cells, JAM was recruited to the nectin-based cell-cell adhesion sites. This recruitment of JAM was inhibited by nectin inhibitors, which inhibited the trans-interaction of nectin. Microbeads coated with the extracellular fragment of nectin, that interacted with cellular nectin, also recruited JAM to the bead-MDCK cell contact sites. Furthermore, when cadherin-deficient L fibroblasts stably expressing both exogenous JAM and nectin (nectin-JAM-L cells) were co-cultured with L fibroblasts expressing only nectin (nectin-L cells), JAM was concentrated at the cell-cell adhesion sites between nectin-JAM-L and nectin-L cells without the trans-interaction of JAM. Analyses of the localization and immunoprecipitation of JAM revealed that it was associated with nectin through afadin and ZO-1. These results suggest that nectin has a role in the localization of JAM at TJs in the process of the formation of the junctional complex in epithelial cells. PMID: 12400007
[Results of treatment of esophageal cancer]. (1994)

From 1.10.1972 until 1.1.1993 176 patients underwent esophageal resection for cancer of the esophagus. There were 72.7% squamous cell carcinomas and 24.4% adenocarcinomas. pTNM staging was as follows: Stage I: 7.3%; stage IIa: 33.5%; stage IIb: 11.9% and stage III 47.1%. The resection was performed in 92.6% by an abdominothoracic approach. Reconstruction was usually performed by transposition of the stomach. Only in 8 patients colon was used for esophageal replacement. The complication rate was 34.6%, mainly pulmonary complications were seen. The rate of anastomotic insufficiency was 6.2%. Hospital mortality was 15.3%, but decreased from 29.1% in the years 1972-1982 to 10.1% in the last decade. There was a significant correlation between the 5-year-survival-rate and the tumor staging respectively the lymph node involvement. The long-term results showed a relatively high percentage of reflux complaints and persistent dysphagia. But the general condition and quality of life were considered subjectively by 53.5% as good and by 42.8% as moderate. From these results it can be concluded, that surgery today offers the best chances for potential cure and a high quality of life.
Pressure-dependent sensitivity of battery based methane detection system using tunable diode laser at 3270 nm (2020)

A compact, single-pass and low-power-consumption methane sensing system is presented and its sensitivity is investigated for a set of reference cells with pressures of 7.4, 74 and 740 Torr and the same methane concentration of 1351 ppm. A single-mode GaSb-based continuous-wave (CW) distributed feedback (DFB) tunable diode laser at 3270 nm and wavelength modulation spectroscopy were employed to collect 2f spectra in the &nu;<sub>3</sub>,R<sub>3</sub> band of <sup>12</sup>CH<sub>4</sub>. A modulated Voigt line profile model was used to fit the collected 2f spectra. The best detectivity of 4 ppbm is obtained for the highest pressure cell using an Allan-Werle variance analysis.
NASA volcanology field workshops on Hawai‘i: Part 2. Understanding lava flow morphology and flow field emplacement (2011)

The Big Island of Hawai'i presents ample opportunities for young planetary volcanologists to gain firsthand field experience in the analysis of analogs to landforms seen on Mercury, Venus, the Moon, Mars, and Io. In this contribution, we focus on a subset of the specific features that are included in the planetary volcanology field workshops described in the previous chapter in this volume. In particular, we discuss how remote-sensing data and field localities in Hawai'i can help a planetary geologist to gain expertise in the analysis of lava flows and lava flow fields, to understand the best sensor for a specific application, to recognize the ways in which different data sets can be used synergistically for remote interpretations of lava flows, and to gain a deeper appreciation for the spatial scale of features that might be imaged in the planetary context.
IODP Expedition 366 RGB channels (calculated from core photos) (2020)

Red, green, and blue pixel data were extracted from Section Half Imaging Logger (SHIL) linescan images, typically binned at 0.5 cm resolution using the central 2 cm of the image.
Molecular characterization of pcp, the structural gene encoding the pyrrolidone carboxylyl peptidase from Streptococcus pyogenes (1992)

This paper describes the cloning of a gene (pcp) coding for pyrrolidone carboxylyl peptidase (PYRase), an enzyme which selectively removes N-terminal pyroglutamic acid residues from polypeptides. This gene was isolated from Streptococcus pyogenes by construction of a gene library with a bacteriophage lambda-derived cosmid-Escherichia coli host system. Nucleotide sequence determination of a 1.3 kb restriction fragment revealed a 645 bp open reading frame encoding a 215-amino-acid product of M(r) 23,135 consistent with the 26 kDa polypeptide obtained from in vivo overexpression in E. coli. Southern hybridization confirmed that pcp is a single-copy gene on the S. pyogenes chromosome. 5' and 3' endpoint mapping of the 0.7 kb specific transcript observed by Northern analysis permitted the identification of transcriptional initiation and termination signals. Structural features of the pcp gene product from S. pyogenes are discussed and compared with that from Bacillus subtilis. The lack of sequence identity with any other known protein or nucleotide sequence suggests that this enzyme belongs to a new class of peptidase.
Cancellation of GLONASS signals from Radio Astronomy Data (2000)

Astronomers use the 1612 MHz OH spectral line emission as a unique window on properties of evolved stars, galactic dynamics, and putative proto-planetary disk systems around young stars. In recent years, experiments using this OH line have become more difficult because radio telescopes are very sensitive to transmissions from the GLONASS satellite system. The weak astronomical signals are often undetectable in the presence of these unwanted human generated signals. In this paper we demonstrate that GLONASS narrow band signals may be removed using digital signal processing in a manner that is robust and non-toxic to the weak astronomy signals, without using a reference antenna. We present results using real astronomy data and outline the steps required to implement useful systems on radio telescopes.
Naloxone injections into CA3 disrupt pattern completion associated with relapse from cocaine seeking (2016)

The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired cues. After 21 days of abstinence and prior to the preference test, for one group, PBS or naloxone was injected into the CA3 subregion of the hippocampus and for a second group, saline or naloxone was injected systemically. The results indicated that infusions of naloxone into CA3 or systemic injections produced a marked disruption for one and two cues, but had minimal disruptive effect for three or four cues, suggesting that naloxone injections disrupt CA3 function and trigger a deficit in a pattern completion process. Thus, it appears that cue-based activation of the dorsal CA3 might be a critical trigger via a pattern completion process. Based on additional analyses it appears that there is a disruption primarily for object touches for one cue naloxone injections into the CA3 or systemic injections, but no effect on time (spatial context). © 2016 Wiley Periodicals, Inc.
Modification of Hogarth models on the stripe costume (2016)

Purpose Beautiful and simple curves are most commonly employed in apparel design since they can not only simplify the manufacture process, but also significantly beautify the breast profile of customers. However, it is regularly difficult to choose the most suitable curve when producing the strip costume; this is due to the fact that the curve is a kind of aesthetics without any laws. The quantification and standardization to curves are necessary for fashion design. The purpose of this paper is to investigate the relationship between the stripe of costumes and the breast profiles of wearers. Design/methodology/approach Seven curves drawn derived from the Hogarth theory (Hogarth curves) were firstly diagrammatized by the central line technology using CorelDraw, and the format of bitmaps and quadratic functions of these selected curves were obtained respectively. Simulating formulas were subsequently used to interpret these curves. The standard of curves for apparel design was finally established after being evaluated by comparison between the different types of female breasts and the curves on the costumes. Findings The established models indicated that the fourth Hogarth curves was the most attractive one that combining the static state and the dynamic beauty, which could also help females to highlight the beautiful breast shapes. Originality/value This work provided the fundamentally understanding of the application of Hogarth curves in fashion design and the improvement on the effectiveness of the garment industry.
Dynamic On-Line Updating Solution for CURE Cubes (2008)

CURE is an efficient ROLAP algorithm both on construction time and utility of storage. A new updating method for cubes generated by CURE, dynamic on-line updating solution (DOLUS) is presented here in which dynamic means updating cubes incrementally and on-line guarantees concurrent of updating and query answering except the period of incremental construction in memory. DOLUS takes advantage of original CURE and brings in new writing strategies. After being updated by DOLUS, cubes appear a little different from the original CURE ones, as trivial tuples and common aggregate tuples become less and normal tuples become more. However, the query answering time is at least the same or less. Those are the result of performance tradeoff between query-optimize and storage-optimize.
Testing and evaluation of large-area heliostats for solar thermal applications (1993)

Two heliostats representing the state-of-the-art in glass-metal designs for central receiver (and photovoltaic tracking) applications were tested and evaluated at the National Solar Thermal Test Facility in Albuquerque, New Mexico from 1986 to 1992. These heliostats have collection areas of 148 and 200 m{sup 2} and represent low-cost designs for heliostats that employ glass-metal mirrors. The evaluation encompassed the performance and operational characteristics of the heliostats, and examined heliostat beam quality, the effect of elevated winds on beam quality, heliostat drives and controls, mirror module reflectance and durability, and the overall operational and maintenance characteristics of the two heliostats. A comprehensive presentation of the results of these and other tests is presented. The results are prefaced by a review of the development (in the United States) of heliostat technology.
Acetabular Cages: A Ladder Across a Melting Pond (2004)

implanting anti-protrusio devices was based on an attempt to provide increased contact area between the implant and remaining pelvic bone to dissipate forces within the cement and decrease the likelihood of implant migration. Early devices relied on cement as the sole source of fixation and these implants were associated with a high failure rate at short-term follow-up. Although the use of these devices was quickly abandoned, new devices based on mechanical screw fixation were designed and the use of these devices became popular in the early 1990s.1 These so-called “acetabular cages” should be classified into the two categories: 1) roof rings and 2) anti-protrusio devices.2,3 This distinction is important as significant differences exist between these two device categories and they should be used to treat different conditions. This article reports on the anti-protrusio devices that are used to bridge across from the ischium to the ilium to dissipate the forces in poor or absent bone.
Network on Chip: A review on data security and privacy issues (2021)

A network on chip (NoC) is an integrated circuit with a network-based communication subsystem. NoC helps to achieve better throughput in multi-core chips. The NoC is a novel method to solve the scalability problems that System on Chips (SoC) have. NoC is capable of handling a large number of applications that require security. As the NoC is visible to all communications in SoCs, and its increased usage and the chip’s distributed nature has made it a goal for future security attacks. Because of the increased complexity, any of the Intellectual property (IP) cores embedded on SoCs are being pushed to be outsourced to different third-party suppliers in order to satisfy the restrictions on time-to-market. The third-party suppliers can be trusted or untrusted. The untrusted IPs integrated on the same IP cores from the trusted vendors can degrade the performance or tamper with the packets. So one of the major problems in this area is how to protect the data we are sending through the chip. In this paper, firstly, the concepts and features of NoC are introduced and then provides the advantages and challenges of different security mechanisms used to protect the contents and to detect the threats in NoC. This paper would be helpful for the study of NoC security, vulnerabilities, and security threats.
Inhomogeneous Point-Processes to Instantaneously Assess Affective Haptic Perception through Heartbeat Dynamics Information (2016)

This study proposes the application of a comprehensive signal processing framework, based on inhomogeneous point-process models of heartbeat dynamics, to instantaneously assess affective haptic perception using electrocardiogram-derived information exclusively. The framework relies on inverse-Gaussian point-processes with Laguerre expansion of the nonlinear Wiener-Volterra kernels, accounting for the long-term information given by the past heartbeat events. Up to cubic-order nonlinearities allow for an instantaneous estimation of the dynamic spectrum and bispectrum of the considered cardiovascular dynamics, as well as for instantaneous measures of complexity, through Lyapunov exponents and entropy. Short-term caress-like stimuli were administered for 4.3-25 seconds on the forearms of 32 healthy volunteers (16 females) through a wearable haptic device, by selectively superimposing two levels of force, 2 N and 6 N, and two levels of velocity, 9.4 mm/s and 65 mm/s. Results demonstrated that our instantaneous linear and nonlinear features were able to finely characterize the affective haptic perception, with a recognition accuracy of 69.79% along the force dimension, and 81.25% along the velocity dimension.
High‐resolution proteome/peptidome analysis of peptides and low‐molecular‐weight proteins in urine (2007)

All organisms contain thousands of proteins and peptides in their body fluids. A deeper insight into the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the discovery of specific peptide biomarkers would greatly enhance diagnosis and therapy of specific diseases. The low-molecular-weight proteome, also termed peptidome, provides a rich source of information. Due to its unique features, the technical challenges differ somewhat from those in "common" proteomics. In this manuscript, we focus on the low-molecular-weight urinary proteome. We review the methodological aspects of sample collection, preparation, analysis, and subsequent data evaluation. In the second part of this review, we summarize the recent progress in the definition and identification of clinically relevant polypeptide markers.
ChemInform Abstract: SYNTHESIS AND PLATELET AGGREGATION INHIBITORY ACTIVITY OF 6‐ISOBUTYL‐α‐METHYL‐3‐PYRIDINEACETIC ACID (1979)

Abstract Das Nitril (I) wird über (II)‐(V) in das Epoxid (VI) umgewandelt, das aber nicht in die gewünschte Verbindung (VII) übergeführt werden kan Letztere ist dagegen ausgehend von (I) über den Enolether (X) zugänglich, der sich oxidativ in den Carbonsäureester (XI) umlagern läßt. Die Chlorcarbonsäure (XII) wird zur Verbindung (XIII) verestert und dechloriert.
ChemInform Abstract: Stereospecific Synthesis of Chiral Alkinylogous Amino Acids. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.