gebhart/patrepeval huggingface dataset:
An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein (2000)

1-O-beta-acyl acetals serve as activated donors in group transfer reactions involved in plant natural product biosynthesis and hormone metabolism. However, the acyltransferases that mediate transacylation from 1-O-beta-acyl acetals have not been identified. We report the identification of a cDNA encoding a 1-O-beta-acylglucose-dependent acyltransferase functioning in glucose polyester biosynthesis by Lycopersicon pennellii. The acyltransferase cDNA encodes a serine carboxypeptidase-like protein, with a conserved Ser-His-Asp catalytic triad. Expression of the acyltransferase cDNA in Saccharomyces cerevisiae conferred the ability to disproportionate 1-O-beta-acylglucose to diacylglucose. The disproportionation reaction is regiospecific, catalyzing the conversion of two equivalents of 1-O-beta-acylglucose to 1, 2-di-O-acylglucose and glucose. Diisopropyl fluorophosphate, a transition-state analog inhibitor of serine carboxypeptidases, inhibited acyltransferase activity and covalently labeled the purified acyltransferase, suggesting the involvement of an active serine in the mechanism of the transacylation. The acyltransferase exhibits no carboxypeptidase activity; conversely, the serine carboxypeptidases we have tested show no ability to transacylate using 1-O-acyl-beta-glucoses. This acyltransferase may represent one member of a broader class of enzymes recruited from proteases that have adapted a common catalytic mechanism of catabolism and modified it to accommodate a wide range of group transfer reactions used in biosynthetic reactions of secondary metabolism. The abundance of serine carboxypeptidase-like proteins in plants suggests that this motif has been used widely for metabolic functions.
A Highly Automated Semi Custom Design Approach for VLSI (1981)

This paper describes a structured approach for VLSI chip design coupled to automatic physical design tools providing a quasi custom capability with a drastic reduction of design resources and time.
Biocatalytic Oxidative CC Bond Formation Catalysed by the Berberine Bridge Enzyme: Optimal Reaction Conditions (2011)

Abstract Berberine bridge enzyme (BBE) catalyses the oxidative formation of an intramolecular CC bond using ( S )‐reticuline as the natural substrate to form ( S )‐scoulerine as the product. To allow application of the enzyme on a preparative scale for the synthesis of novel optically pure berbine and isoquinoline derivatives, an organic solvent is required to solubilise the barely soluble substrates. It was shown that BBE tolerates a broad variety of organic co‐solvents. Ideally the enzymatic enantioselective oxidative CC bond formation can be performed in 70% v v −1 toluene concentration, which allowed a soluble substrate concentration of at least 20 g L −1 . In addition, the enzyme works in a broad operational window concerning pH and temperature. High conversions can be reached between pH 8 and 11 and from 30 to 50 °C, respectively. The enantioselective oxidative CC bond formation was demonstrated on a preparative scale (500 mg) in a kinetic resolution leading to optically pure products (&gt;97% ee ).
Properties of 2,3‐dicarboxy cellulose combined with various metallic ions (1984)

Abstract 2,3‐Dicarboxy cellulose and partially oxidized 2,3‐dicarboxy cellulose were prepared in good yields from the corresponding dialdehyde cellulose obtained by periodate oxidation of cellulose according to a modification of the method described by Hofreiter, Wolff, and Mehltretter [ J. Am. Chem. Soc ., 79 , 6457 (1957)]. The 2,3‐dicarboxy cellulose oxidized to nearly 100% oxidation level was completely soluble in water, but the 2,3‐dicarboxy cellulose of 70% oxidation level was not. The former 2,3‐dicarboxy cellulose took up various metallic ions other than alkali metals to form a precipitate or solid. The metal contents taken up corresponded to the theoretical values calculated as combined in the form of metallic salt of the carboxylic acid group. 2,3‐Dicarboxy cellulose combined with metallic ions such as copper, cobalt, and nickel ions gave viscous, gel‐like products, which solidified when exposed to air. The properties of products combined with such metallic ions are discussed.
Execution primitives for scalable joins and aggregations in map reduce (2014)

Analytics on Big Data is critical to derive business insights and drive innovation in today's Internet companies. Such analytics involve complex computations on large datasets, and are typically performed on MapReduce based frameworks such as Hive and Pig. However, in our experience, these systems are still quite limited in performing at scale. In particular, calculations that involve complex joins and aggregations, e.g. statistical calculations, scale poorly on these systems. In this paper we propose novel primitives for scaling such calculations. We propose a new data model for organizing datasets into calculation data units that are organized based on user-defined cost functions. We propose new operators that take advantage of these organized data units to significantly speed up joins and aggregations. Finally, we propose strategies for dividing the aggregation load uniformly across worker processes that are very effective in avoiding skews and reducing (or in some cases even removing) the associated overheads. We have implemented all our proposed primitives in a framework called Rubix, which has been in production at LinkedIn for nearly a year. Rubix powers several applications and processes TBs of data each day. We have seen remarkable improvements in speed and cost of complex calculations due to these primitives.
Phylogenetic Tree Construction Using Markov Chain Monte Carlo (2000)

Abstract We describe a Bayesian method based on Markov chain simulation to study the phylogenetic relationship in a group of DNA sequences. Under simple models of mutational events, our method produces a Markov chain whose stationary distribution is the conditional distribution of the phylogeny given the observed sequences. Our algorithm strikes a reasonable balance between the desire to move globally through the space of phylogenies and the need to make computationally feasible moves in areas of high probability. Because phylogenetic information is described by a tree, we have created new diagnostics to handle this type of data structure. An important byproduct of the Markov chain Monte Carlo phylogeny building technique is that it provides estimates and corresponding measures of variability for any aspect of the phylogeny under study. Key Words: Convergence diagnosticsMetropolis algorithmMolecular evolutionTree distributions
Machine Assisted Video Tagging of Elderly Activities in K-Log Centre (2020)

In a rapidly aging society, like in South Korea, the number of Alzheimer's Disease (AD) patients is a significant public health problem, and the need for specialized healthcare centers is in high demand. Healthcare providers generally rely on caregivers (CG) for elderly persons with AD to monitor and help them in their daily activities. K-Log Centre is a healthcare provider located in Korea to help AD patients meet their daily needs with assistance from CG in the center. The CG'S in the K-Log Centre need to attend the patients' unique demands and everyday essentials for long-term care. Moreover, the CG also describes and logs the day-to-day activities in Activities of Daily Living (ADL) log, which comprises various events in detail. The CG's logging activities can overburden their work, leading to appalling results like suffering quality of elderly care and hiring additional CG's to maintain the quality of care and a negative feedback cycle. In this paper, we have analyzed this impending issue in K-Log Centre and propose a method to facilitate machine-assisted human tagging of videos for logging of the elderly activities using Human Activity Recognition (HAR). To enable the scenario, we use a You Only Look Once (YOLO-v3)-based deep learning method for object detection and use it for HAR creating a multi-modal machine-assisted human tagging of videos. The proposed algorithm detects the HAR with a precision of 98.4%. After designing the HAR model, we have tested it in a live video feed from the K-Log Centre to test the proposed method. The model showed an accuracy of 81.4% in live data, reducing the logging activities of the CG's.
Ligand Reactivity in Diarylamido/Bis(Phosphine) PNP Complexes of Mn(CO)3and Re(CO)3 (2009)

The syntheses of meridionally ligated tricarbonyl complexes (PNP)Mn(CO)(3) and (PNP)Re(CO)(3) are described (PNP = [2-P(CHMe(2))(2)-4-MeC(6)H(3)](2)N(-)). Cyclic voltammograms show reversible one-electron redox couples for both parent compounds (-0.34 V vs Cp(2)Fe(0/+) for (PNP)Mn(CO)(3), -0.25 V vs Cp(2)Fe(0/+) for (PNP)Re(CO)(3)), and chemical oxidation with AgOTf results in formation of the corresponding paramagnetic triflate salts [(PNP)Mn(CO)(3)]OTf and [(PNP)Re(CO)(3)]OTf. Electron paramagnetic resonance spectra and computational results indicate that this event is primarily ligand centered; allylation of the organic ligand moiety of [(PNP)Mn(CO)(3)]OTf with allyltributylstannane is consistent with this assignment. The oxidation (PNP)Mn(CO)(3) to [(PNP)Mn(CO)(3)]OTf results in a shift in average CO stretching frequency of 30 cm(-1); protonation of (PNP)Mn(CO)(3) with TfOH to form [(PNHP)Mn(CO)(3)]OTf results in a similar magnitude shift.
Geometric Modeling and Multi-Axis NC Machining for Custom-Made Femoral Stem (2011)

In this paper, a design system combining clinical experience and engineering knowledge was developed for the manufacture of custom-made femoral stem. The medical image of the hip obtained according to the patient X-rays. The geometric parameters for femoral stem were established based on the canal flare index. The necessary constrains based on surgical experience were integrated into the CAD system. The rapid prototyped model was built as the reference for review. Through the application of CAM software, the interference-free toolpath and the cutter location for multi-axis NC machining are generated. In order to establish the interface between the design and the manufacture of femoral stem, the postprocessor for multi-axis machine tool is developed. The cutting simulations with solid model are performed to verify the generated toolpath. It is also verified through the trial-cut with model material on a five-axis machine tool.
Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer (2006)

These results do not support the use of prophylactic splenectomy to remove macroscopically negative lymph nodes near the spleen in patients undergoing total gastrectomy for proximal gastric cancer.
Veritabanı Yönetim Sistemleri Güvenliği: Tehditler ve Korunma Yöntemleri (2010)

Veritabani yonetim sistemleri (VTYS) kurumlarin veya bireylerin kritik bilgilerinin tutuldugu hassas ve korunmasi gereken yazilimlardir. Internet uzerinden erisilebilen ve veritabanlarini kullanan web uygulamalarinin sayisi her gecen gun artmaktadir. Ag destekli ortamlarda veritabanlari icin alinan guvenlik onlemleri cogunlukla yetersiz kalmakta ve guvenlik ihlalleri yasanmaktadir. Yuksek seviyede VTYS guvenliginin saglanabilmesi icin teknolojik onlemlere ek olarak insan faktoru de dikkate alinmali ve teknik seviyeden idari seviyeye kadar tum kullanicilarda bilgi guvenligi farkindaligi yeterli seviyede olusturulmalidir. VTYS guvenliginin yuksek seviyede saglanmasi icin bu calismada VTYS ile dogrudan veya dolayli olarak etkilesen tum bilesenler aciklanmis ve bu bilesenlere tek bir catidan farkli bir bakis acisiyla bakilmasini saglayan katmanli bir yaklasim sunulmustur. Sunulan katmanli yaklasim sayesinde yuksek seviyede VTYS guvenliginin saglanmasiyla ilgili olarak guvenlik onlemlerinin alinmasina katkida bulunulacagina ve VTYS guvenligi acisindan bir farkindalik olusturacagi degerlendirilmektedir.
Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons (1982)

Sympathetic neurons internalize nerve growth factor (NGF) and transport it retrogradely to their cell bodies where it appears to serve a trophic function in maintaining neuronal survival. We have characterized the binding, internalization, and retrograde transport of 125I-NGF by cultured rat sympathetic neurons. After 3 to 4 weeks in culture, sympathetic neurons possessed approximately 2 X 10(7) specific, cell surface NGF binding sites per neuron with an apparent affinity constant of 2 to 5 X 10(9) M. The density of binding sites on the plasma membrane of the neurites approximately twice that on the plasma membrane of the cell bodies. Because of the extensive network of neuronal processes, the neurites probably account for more than 99.5% of the total binding in mature cultures. Using electron microscope autoradiography, we localized the distribution of 125I-NGF in the cell body following a 1-hr exposure to 125I-NGF. The majority of silver grains were associated with lysosomal organelles, including secondary lysosomes, residual bodies, and multivesicular bodies (MVB). The MVB were the most heavily labeled, with a labeling density (L.D.) of 21, while the lysosomes had a L.D. of 3.1. To study the retrograde transport of 125I-NGF, neurons were grown in compartmentalized culture dishes and their distal processes were exposed to 125I-NGF. Radioactive material was transported to the cell bodies at the rate of approximately 3 mm/hr. The transport mechanism was sensitive to colchicine and was saturable with respect to NGF. After 8 hr of transport, when the radioactivity in the cell bodies had reached a steady state, the label again was localized primarily to the MVB (L.D. = 16.8) and the lysosomes (L.D. = 3.8). The nuclei were not labeled significantly and had an overall L.D. of 0.47. We saw no evidence for the accumulation of NGF by the nuclear membrane, the nucleolus, or chromatin.
Essential Hypertension and Exercise (1981)

In brief: Responses to a questionnaire given to physicians and clinic directors in the Salt Lake City area indicated the current practices in treating essential hypertension. The most common treatment was step-care drug therapy, although some used exercise as a treatment modality. The authors concluded that: (1) the value of exercise in treating hypertension is not completely understood; (2) the undesirable side effects of drug therapy suggest a closer examination of nonpharmacological treatment; (3) borderline or labile hypertensives are often not treated without specific indications; and (4) exercise physiologists might be helpful to physicians who want to use exercise therapy for their hypertensive patients.
Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39‐R43 of β2‐glycoprotein I (2022)

We identified a peptide that selectively bound immunoglobulin G (IgG) derived from APS patients with 100 times more affinity than β2GP1, Domain I, or epitope R39-R43. This peptide is able to inhibit the activity of IgG derived from APS patients in vitro. We have also generated a monoclonal IgG antibody against this peptide. Using both peptide and monoclonal antibody, we have been able to develop a fully standardized indirect colorimetric immunoassay with highly sensitivity. The identification of the optimized peptide offers a new standardized and accurate tool for diagnostics of APS. Furthermore, having increased affinity for aPL, this peptide could represent a useful tool as prevention strategy for APS and an alternative to the use of anticoagulants.
Corrections to Methyl Mercury Formation in Hillslope Soils of Boreal Forests: The Role of Forest Harvest and Anaerobic Microbes (2017)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrections to Methyl Mercury Formation in Hillslope Soils of Boreal Forests: The Role of Forest Harvest and Anaerobic MicrobesRose-Marie Kronberg, Martin Jiskra, Jan G. Wiederhold, Erik Björn, and Ulf Skyllberg*Cite this: Environ. Sci. Technol. 2018, 52, 1, 367Publication Date (Web):December 14, 2017Publication History Published online14 December 2017Published inissue 2 January 2018https://pubs.acs.org/doi/10.1021/acs.est.7b06052https://doi.org/10.1021/acs.est.7b06052correctionACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views910Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (265 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sind TNF-α-Hemmer eine sichere Option zur Behandlung von Psoriasis bei Patienten mit Hepatitis-C-Virus-Infektion und fortgeschrittener Lebererkrankung? Fallberichte und Literaturübersicht (2016)

Inhibitoren des Tumornekrosefaktor alpha (TNF-α-Hemmer) stellen eine wirksame Therapieoption zur Behandlung schwerer Psoriasis bei Hepatitis-C-Virus (HCV)-positiven Patienten dar. In der Literatur wird vorwiegend über die Kurzzeitbehandlung von Patienten mit chronischer Hepatitis von minimaler bis moderater Aktivität berichtet; bei akzeptablem Sicherheitsprofil. Wir berichten über die ersten beiden Fälle der Entstehung eines hepatozellulärem Karzinoms (HCC) bei HCV-positiven Psoriasis-Patienten mit fortgeschrittener Lebererkrankung während einer Langzeitbehandlung mit Etanercept. Beim ersten Patienten war die HCV-Infektion seit 41 Jahren bekannt; er entwickelte nach 21-monatiger Behandlung mit Etanercept (50 mg/Woche) ein HCC. Der zweite Patient war seit 20 Jahren HCV-positiv, wurde 58 Monate lang mit demselben Therapieschema behandelt und schließlich HCC-diagnostiziert, und obwohl keine Anzeichen einer Leberfunktionsstörung vorlagen. Beide Patienten hatten sich mit einer Zirrhose vorgestellt, die 9 bzw. 5 Jahre zuvor diagnostiziert worden war. Es bleibt zu klären, ob zwischen der Psoriasis-Behandlung mit einem Tnf-α-Hemmer und der Entwicklung des HCC bei den HCV-infizierten Patienten ein Zusammenhang besteht. Weitere Langzeit-Follow-up-Studien und Register von HCV-Patienten mit leichter/moderater Aktivität könnten zur Klärung dieser Frage beitragen.
Catalytic hydroconversion of lignin to monomers (2019)

SSCI-VIDE+ECI2D+DLA:CGE
Formation of Pyramidal Etch Pits Induced by Metallic Particles on Ge(100) Surfaces in Water (2011)

We demonstrate that pyramidal etch pits composed of (111) micro facets are formed on single-crystalline Ge(100) surfaces when the Ge samples with metallic particles are immersed into water. The mechanism behind this anisotropic etching is the enhanced oxidation of Ge around metallic particles by the catalytic activity of noble metals to reduce dissolved oxygen (O2) to water molecules, and the subsequent removal of the oxide in water due to the soluble nature of Ge oxides. This enhanced etching of Ge surfaces is observed not only with metallic particles but also with a metallic thin film. The results insist that remaining metallic contaminants can roughen Ge surfaces during a rinse process with water, which will be important to design wet cleaning processes for Ge wafers.
Improving Hemocompatibility of Membranes for Extracorporeal Membrane Oxygenators by Grafting Nonthrombogenic Polymer Brushes (2018)

Nonthrombogenic modifications of membranes for extracorporeal membrane oxygenators (ECMOs) are of key interest. The absence of hemocompatibility of these membranes and the need of anticoagulation of patients result in severe and potentially life-threatening complications during ECMO treatment. To address the lack of hemocompatibility of the membrane, surface modifications are developed, which act as barriers to protein adsorption on the membrane and, in this way, prevent activation of the coagulation cascade. The modifications are based on nonionic and zwitterionic polymer brushes grafted directly from poly(4-methyl-1-pentene) (TPX) membranes via single electron transfer-living radical polymerization. Notably, this work introduces the first example of well-controlled surface-initiated radical polymerization of zwitterionic brushes. The antifouling layers markedly increase the recalcification time (a proxy of initiation of coagulation) compared to bare TPX membranes. Furthermore, platelet and leukocyte adhesion is drastically decreased, rendering the ECMO membranes hemocompatible.
Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients (2012)

Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD.
Computational Prediction and Experimental Realization of p-Type Carriers in the Wide-Band-Gap Oxide SrZn1–xLixO2 (2018)

It is challenging to achieve p-type doping of zinc oxides (ZnO), which are of interest as transparent conductors in optoelectronics. A ZnO-related ternary compound, SrZnO<sub>2</sub>, was investigated as a potential host for p-type conductivity. First-principles investigations were used to select from a range of candidate dopants the substitution of Li<sup>+</sup> for Zn<sup>2+</sup> as a stable, potentially p-type, doping mechanism in SrZnO<sub>2</sub>. Subsequently, single-phase bulk samples of a new p-type-doped oxide, SrZn<sub>1- x</sub>Li <sub>x</sub>O<sub>2</sub> (0 < x < 0.06), were prepared. The structural, compositional, and physical properties of both the parent SrZnO<sub>2</sub> and SrZn<sub>1- x</sub>Li <sub>x</sub>O<sub>2</sub> were experimentally verified. The band gap of SrZnO<sub>2</sub> was calculated using HSE06 at 3.80 eV and experimentally measured at 4.27 eV, which confirmed the optical transparency of the material. Powder X-ray diffraction and inductively coupled plasma analysis were combined to show that single-phase ceramic samples can be accessed in the compositional range x < 0.06. A positive Seebeck coefficient of 353(4) μV K<sup>-1</sup> for SrZn<sub>1- x</sub>Li <sub>x</sub>O<sub>2</sub>, where x = 0.021, confirmed that the compound is a p-type conductor, which is consistent with the p<sub>O<sub>2</sub></sub> dependence of the electrical conductivity observed in all SrZn<sub>1- x</sub>Li <sub>x</sub>O<sub>2</sub> samples. The conductivity of SrZn<sub>1- x</sub>Li <sub>x</sub>O<sub>2</sub> is up to 15 times greater than that of undoped SrZnO<sub>2</sub> (for x = 0.028 σ = 2.53 μS cm<sup>-1</sup> at 600 °C and 1 atm of O<sub>2</sub>).
Photochromic point-diffraction interferometer for optical testing (2012)

The principles for the realization of rewritable point-diffraction interferometers (PDIs) based on photochromic polyurethane films are described. Pinholes of variable sizes (diameter from 4 to 40 &mu;m) have been optically written onto photochromic substrates converting locally the material from the colored to the uncolored form. The PDIs have been mounted in an interferometric setup and different reflective optics have been tested. By a controlled bleaching of the semi-transparent area around the pinhole, an optimal visibility in the interferograms is reached. Under this conditions several tests of reliability of the interferometer have been carried out.