gebhart/patrepeval huggingface dataset:
The MIT Design Advisor : simple and rapid energy simulation of early-stage building designs (2007)

Simulation tools, when applied early in the design process, can considerably reduce the energy demand of newly constructed buildings.For a simulation tool to assist with design, it must be easy to use, provide feedback quickly, and allow rapid comparisons.Most existing tools do not meet these needs, usually because they were intended for modeling finalized building designs.Often there is no user interface, and it can take hours or days to prepare, run, and interpret results.Such tools are too sophisticated for design purposes.In this document the MIT Design Advisor is presented as a simple and rapid building energy simulation tool, developed specifically for architects and building designers.Conceptual building designs can be modeled quickly and without formal training.Results are interpreted graphically and displayed to the user in a simple user interface.Side-by-side comparisons of building designs can be made, allowing users to quickly learn which building components have the biggest impact on energy consumption (heating, cooling, and lighting), indoor daylight levels, and thermal comfort.User-specified building parameters are used together with local weather data to predict monthly and annual energy use.The heat transfer model used to make the energy predictions is explained in detail in this thesis.Calculation methods are given and validated.
Efficient unicast routing algorithms in Software-Defined Networking (2016)

The recently developed Software-Defined Networking (SDN) provides flexibility, scalability and reduce the cost of hardware for operators and vendors. In this paper, we propose four routing algorithms in SDN to minimize network latency and balance the traffic load of each switch link in a network. The first routing algorithm is the shortest path first (SPF) algorithm. The SPF algorithm can find the shortest path with maximum bottleneck bandwidth (MBB) among all shortest paths. The second algorithm is the bandwidth aware routing (BAR) algorithm. The BAR algorithm can find a path with MBB on a network. The third algorithm is the k-SPF, which can find a path with MBB among the first k shortest paths. Finally, our fourth algorithm k-BAR can find the shortest path among the first k MBB paths on a network. Simulation results show that the performance of our algorithms is better than previous works.
Automated design optimization and trade studies using STK scenarios (2005)

Optimizing a constellation of space, air, and ground assets is typically a man-in-the-loop intensive and iterative process. Designers must originate a few baseline concepts and then intuitively explore design variations within a large multi-dimensional trade space. To keep the search manageable, options and variations are often severely limited. There is a clear advantage to automate, in an intelligent and efficient manner, this search for optimal design solutions. Such automation would greatly open the analyzable options, increasing insight, improving solutions, and saving money. For this reason, Boeing has initiated a software application that automates STK&reg; scenarios and intelligently searches for optimal solutions. Now in the post-prototype stages of development, “AVA” has provided extremely valuable solutions and insight into several space-based architectures and their proposed payloads. This paper will discuss the current state of the AVA tool, methods, applicability, and the potential for future growth.
Imbibition capillaire d'un échantillon de bois : reconstitution 3D de l'anatomie et simulation Lattice Boltzmann (2009)

Colloque avec actes et comité de lecture. Internationale.
Superchanneling of accelerated ions through crystals with large channels (1978)

350-keV protons were transmitted through beryl crystals of thicknesses up to 58 μm. The dependence of the output/input flux ratio upon the angle of incidence indicates the existence of a superchanneling effect caused by the large channel diameter. The channel effect is strongly dependent on purity and perfection of the crystals.
Investor Education: Internet for Investors (2009)

Do you know about the information and portfolio services that you could obtain for free on the internet? There are many excellent investment tools and services available online. You can find out which sites are the best, how to use them and what they offer at the upcoming ASA national conference workshop, Internet for Investors. Workshop presenter and ASA chairperson, Helen Dent, profiles two of these websites.
Design and Synthesis of 3D Potassium-Ion Pre-Intercalated Graphene for Supercapacitors (2018)

In this paper, a novel material—3D potassium-ion preintercalated graphene—was designed and synthesized via one step using a new reaction between K and CO. Furthermore, this material exhibited excellent performance as electrodes for aqueous symmetrical supercapacitors. When the electrode was scaled up from 3.0 to 8.0 mg/cm2, negligible capacitance degradation was observed, leading to a very high areal capacitance of 1.50 F/cm2 at 1 A/g. Furthermore, even if a large operating temperature of −15 or 55 °C was employed, its excellent electrochemical performance remained with specific capacitances of 208 F/g at 55 °C, 184 F/g at 25 °C, and 98 F/g at −15 °C. This could be attributed to 3D structure and K+ preintercalation of the material, which provides rich active sites for electric double-layer formation, lower ion transport resistance, and shorter diffusion distance.
Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carcinoma xenografts in nude mice. (1996)

Cisplatin (DDP) is commonly used to treat head and neck tumors. Therapy frequently fails due to development of DDP resistance or toxicities associated with DDP therapy. In this study, effects of ALRT1057 [9-cis retinoic acid (9-cis RA)] on DDP cytotoxicity were studied in a human oral squamous carcinoma xenograft model. Mice bearing xenografts were dosed p.o. daily 5 days/week with 30 mg/kg 9-cis RA and/or i.p. twice weekly with 0.3-0.9 mg/kg DDP. Maximum tolerated doses of 9-cis RA and DDP were approximately 60 and >/=2.9 mg/kg, respectively, under their dosing schedules and routes of administration. Control tumors grew rapidly with mean doubling times of 4 +/- 1 days and reached mean volumes of 1982 +/- 199 (SE) mm3 after 24 days. DDP at doses of 0.3, 0.45, and 0.9 mg/kg inhibited tumor growth by 28, 47, and 86%, respectively, 24 days after tumor cell implantation. Thirty mg/kg 9-cis RA inhibited tumor growth by 25%. In combination, 0.3 mg/kg DDP + 30 mg/kg 9-cis RA inhibited tumor growth by 68%; 0.45 mg/kg DDP + 30 mg/kg 9-cis RA inhibited growth by 78%. These decreases were greater than those that would have been produced by either agent summed separately. Of importance, at doses of 9-cis RA that enhanced DDP cytotoxicity, no change in dose tolerance was observed as compared to tolerances observed for either agent alone, indicating that 9-cis RA increased sensitivity to DDP without altering systemic toxicity. In addition, 9-cis RA profoundly altered squamous cell carcinoma phenotypes by suppressing squamous cell differentiation, resulting in tumors with increased numbers of basal cells. In contrast, DDP selectively depleted proliferating basal cells from carcinomas. In combination, morphological changes produced by 9-cis RA alone predominated, suggesting a possible basis for enhanced DDP sensitivity in tumors exposed to both agents. These data demonstrate that 9-cis RA enhances tumor sensitivity to DDP, and suggest that this combination should be tested in Phase I-II clinical trials for its potential for improving anticancer therapy of squamous cell cancers.
Practical Guides (1988)

THE MARKETER'S GUIDE TO MEDIA VEHICLES, METHODS, AND OPTIONS by Ann Grossman (Westport, CT: Quorum Books/Greenwood Press, 1987—$39.95) AUDIOVISUAL TECHNOLOGY PRIMER by Albert Casciero and Raymond Roney (Englewood, CO: Libraries Unlimited, 1988—$22.50 in the U.S.; $27.00 elsewhere) MEDIA WRITING: PREPARING INFORMATION FOR THE MASS MEDIA by Doug Newsom and James Wollert (Belmont, CA: Wadsworth, 1988—price not given, paper) TRANSLATE TO COMMUNICATE: A GUIDE FOR TRANSLATORS by Mary M.F. Massoud (David C. Cook Foundation, Elgin, IL 60120—$9.95, paper: ISBN 1-55513-432-7) PUBLIC RELATIONS PROGRAMMING AND PRODUCTION by E. W. Brody (New York: Praeger, 1988—$45.95/18.95)
Communication-Optimal Parallel Algorithm for Strassen's Matrix Multiplication (2012)

Parallel matrix multiplication is one of the most studied fundamental problems in distributed and high performance computing. We obtain a new parallel algorithm that is based on Strassen's fast matrix multiplication and minimizes communication. The algorithm outperforms all known parallel matrix multiplication algorithms, classical and Strassen-based, both asymptotically and in practice. A critical bottleneck in parallelizing Strassen's algorithm is the communication between the processors. Ballard, Demmel, Holtz, and Schwartz (SPAA'11) prove lower bounds on these communication costs, using expansion properties of the underlying computation graph. Our algorithm matches these lower bounds, and so is communication-optimal. It exhibits perfect strong scaling within the maximum possible range. Benchmarking our implementation on a Cray XT4, we obtain speedups over classical and Strassen-based algorithms ranging from 24% to 184% for a fixed matrix dimension n=94080, where the number of nodes ranges from 49 to 7203. Our parallelization approach generalizes to other fast matrix multiplication algorithms.
KidsTube: Detection, Characterization and Analysis of Child Unsafe Content & Promoters on YouTube (2016)

YouTube draws large number of users who contribute actively by uploading videos or commenting on existing videos. However, being a crowd sourced and large content pushed onto it, there is limited control over the content. This makes malicious users push content (videos and comments) which is inappropriate (unsafe), particularly when such content is placed around cartoon videos which are typically watched by kids. In this paper, we focus on presence of unsafe content for children and users who promote it. For detection of child unsafe content and its promoters, we perform two approaches, one based on supervised classification which uses an extensive set of video-level, user-level and comment-level features and another based Convolutional Neural Network using video frames. Detection accuracy of 85.7% is achieved which can be leveraged to build a system to provide a safe YouTube experience for kids. Through detailed characterization studies, we are able to successfully conclude that unsafe content promoters are less popular and engage less as compared with other users. Finally, using a network of unsafe content promoters and other users based on their engagements (likes, subscription and playlist addition) and other factors, we find that unsafe content is present very close to safe content and unsafe content promoters form very close knit communities with other users, thereby further increasing the likelihood of a child getting getting exposed to unsafe content.
Suppression of Substrate Crosstalk in Mixed-Signal Complementary MOS Circuits Using High-Resistivity SIMOX (Separation by IMplanted OXygen) Wafers (2000)

We investigated the effectiveness of high-resistivity SIMOX (Separation by IMplanted OXygen) wafers to suppress substrate crosstalk. Small- and large-signal crosstalk measurements yielded similar results, which indicated that the frequency dependence of both types of crosstalk could be understood by analyzing the small-signal data. With the measured data, we constructed a model of substrate crosstalk with lumped elements, and found that the model described substrate crosstalk accurately. We also measured the crosstalk between actual digital and analog circuits. The measured and calculated data showed that high-resistivity SIMOX wafers could reduce substrate crosstalk by 5–10 dB in mixed-signal complementary metal-oxide-semiconductor (CMOS) circuits. Hence, we concluded that using high-resistivity SIMOX wafers was an effective way to suppress substrate crosstalk in mixed-signal CMOS circuits.
The immunotherapeutic potential of dendritic cells in type 1 diabetes (2010)

Type 1 diabetes is an autoimmune disease characterized by destruction of the pancreatic islet beta cells that is mediated primarily by T cells specific for beta cell antigens. Insulin administration prolongs the life of affected individuals, but often fails to prevent the serious complications that decrease quality of life and result in significant morbidity and mortality. Thus, new strategies for the prevention and treatment of this disease are warranted. Given the important role of dendritic cells (DCs) in the establishment of peripheral T cell tolerance, DC-based strategies are a rational and exciting avenue of exploration. DCs employ a diverse arsenal to maintain tolerance, including the induction of T cell deletion or anergy and the generation and expansion of regulatory T cell populations. Here we review DC-based immunotherapeutic approaches to type 1 diabetes, most of which have been employed in non-obese diabetic (NOD) mice or other murine models of the disease. These strategies include administration of in vitro-generated DCs, deliberate exposure of DCs to antigens before transfer and the targeting of antigens to DCs in vivo. Although remarkable results have often been obtained in these model systems, the challenge now is to translate DC-based immunotherapeutic strategies to humans, while at the same time minimizing the potential for global immunosuppression or exacerbation of autoimmune responses. In this review, we have devoted considerable attention to antigen-specific DC-based approaches, as results from murine models suggest that they have the potential to result in regulatory T cell populations capable of both preventing and reversing type 1 diabetes.
Enhanced Location Privacy Preserving Scheme in Location-Based Services (2014)

With the increasing popularity of mobile communication devices loaded with positioning capabilities (e.g., GPS), there is growing demand for enjoying location-based services (LBSs). An important problem in LBSs is the disclosure of a user's real location while interacting with the location service provider (LSP). To address this issue, existing solutions generally introduce a trusted <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><i>Anonymizer</i></b> between the users and the LSP. However, the introduction of an Anonymizer actually transfers the security risks from the LSP to the Anonymizer. Once the Anonymizer is compromised, it may put the user information in jeopardy. In this paper, we propose an enhanced-location-privacy-preserving scheme for the LBS environment. Our scheme employs an entity, termed Function Generator, to distribute the spatial transformation parameters periodically, with which the users and the LSP can perform the mutual transformation between a real location and a pseudolocation. Without the transforming parameters, the Anonymizer cannot have any knowledge about a user's real location. The main merits of our scheme include the following: 1) no fully trusted entities are required, and 2) each user can obtain accurate points of interest while preserving location privacy. The efficiency and effectiveness of the proposed scheme are validated by extensive experiments. The experimental results show that the proposed scheme preserves location privacy at low computational and communication cost.
Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane (2006)

Summary The intraerythrocytic developmental stages of the malaria parasite Plasmodium falciparum are responsible for the clinical symptoms associated with malaria tropica. The non‐infected human erythrocyte is a terminally differentiated cell that is unable to synthesize proteins and lipids de novo , and it is incapable of importing a number of solutes that are essential for parasite proliferation. Approximately 12–15 h after invasion the parasitized cell undergoes a marked increase in its permeability to a variety of different solutes present in the extracellular milieu. The increase is due to the induction in the erythrocyte membrane of ‘new permeability pathways’ which have been characterized in some detail in terms of their transport and electrophysiological properties, but which are yet to be defined at a molecular level. Here we show that these pathways are resistant to trypsin but are abolished by treatment of intact infected erythrocytes with chymotrypsin. On resuspension of chymotrypsinized cells in chymotrypsin‐free medium the pathways progressively reappear, a process that can be inhibited by cytotoxic agents, and by brefeldin A which inhibits protein secretion. Our results provide evidence for the involvement of parasite encoded proteins in the generation of the pathways, either as components of the pathways themselves or as auxiliary factors.
(−)‑Epigallocatechin‑3‑O‑gallate upregulates the expression levels of miR‑6757‑3p, a suppressor of fibrosis‑related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells (2023)

As pulmonary fibrosis (PF), a severe interstitial pulmonary disease, has such a poor prognosis, the development of prevention and treatment methods is imperative. (-)-Epigallocatechin-3-<i>O</i>-gallate (EGCG), one of the major catechins in green tea, exerts an antifibrotic effect, although its mechanism remains unclear. Recently, it has been reported that microRNAs (miRNAs or miRs) transported by extracellular vesicles (EVs) from vascular endothelial cells (VECs) are involved in PF. In the present study, the effects of EGCG on the expression of miRNAs in EVs derived from human umbilical vein endothelial cells (HUVECs) were assessed and miRNAs with antifibrotic activity were identified. miRNA microarray analysis revealed that EGCG modulated the expression levels of 31 miRNAs (a total of 27 miRNAs were upregulated, and 4 miRNAs were downregulated.) in EVs from HUVECs. Furthermore, TargetScan analysis indicated that miR-6757-3p in particular, which exhibited the highest degree of change, may target transforming growth factor-β (TGF-β) receptor 1 (TGFBR1). To evaluate the effects of miR-6757-3p on TGFBR1 expression, human fetal lung fibroblasts (HFL-1) were transfected with an miR-6757-3p mimic. The results demonstrated that the miR-6757-3p mimic downregulated the expression of TGFBR1 as well the expression levels of fibrosis-related genes including fibronectin and α-smooth muscle actin in TGF-β-treated HFL-1 cells. In summary, EGCG upregulated the expression levels of miR-6757-3p, which may target TGFBR1 and downregulate fibrosis-related genes, in EVs derived from VECs.
Supplementary Table 7 from Inactivation of <i>Fbxw7</i> Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade (2023)

&lt;p&gt;Antibodies used in this manuscript&lt;/p&gt;
Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial (2015)

ClinicalTrials.gov NCT01269112 . Registered 3rd January 2011.
Identification of Monocarboxylate Transporter 8 as a Specific Thyroid Hormone Transporter (2003)

Transport of thyroid hormone across the cell membrane is required for its action and metabolism. Recently, a T-type amino acid transporter was cloned which transports aromatic amino acids but not iodothyronines. This transporter belongs to the monocarboxylate transporter (MCT) family and is most homologous with MCT8 (SLC16A2). Therefore, we cloned rat MCT8 and tested it for thyroid hormone transport in Xenopus laevis oocytes. Oocytes were injected with rat MCT8 cRNA, and after 3 days immunofluorescence microscopy demonstrated expression of the protein at the plasma membrane. MCT8 cRNA induced an approximately 10-fold increase in uptake of 10 nM 125I-labeled thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) and 3,3'-diiodothyronine. Because of the rapid uptake of the ligands, transport was only linear with time for <4 min. MCT8 did not transport Leu, Phe, Trp, or Tyr. [125I]T4 transport was strongly inhibited by L-T4, D-T4, L-T3, D-T3, 3,3',5-triiodothyroacetic acid, N-bromoacetyl-T3, and bromosulfophthalein. T3 transport was less affected by these inhibitors. Iodothyronine uptake in uninjected oocytes was reduced by albumin, but the stimulation induced by MCT8 was markedly increased. Saturation analysis provided apparent Km values of 2-5 microM for T4, T3, and rT3. Immunohistochemistry showed high expression in liver, kidney, brain, and heart. In conclusion, we have identified MCT8 as a very active and specific thyroid hormone transporter.
A Study to Determine the Robustness of Reference Signals for BSSR Signal Extraction Method (2007)

Blind source separation with reference signals (BSSR) is an excellent method to extract target independent components from linearly mixed observed signals when prior rough information about target signals is given. Usually the slight change of reference signal form does not affect the extraction ability of BSSR, but the extent of this robustness is not yet precisely known. We studied the main parameters of the robustness through examples of fetal electrocardiogram extraction.
Magnetic hyperthermia – high therapeutic efficiency of superparamagentic iron oxide nanoparticles in cancer xenograft models (2014)

Magnetic fluid hyperthermia (MFH) is a promising method for the minimal invasive treatment of tumors. However, optimized nanomaterials to supply thermal stress inside the tumor remain to be identified. The present study investigates the therapeutic effects of magnetic hyperthermia induced by superparamagnetic iron oxide nanoparticles in two xenograft- models.