gebhart/patrepeval huggingface dataset:
Computational fluid dynamic modeling to predict wall shear stress in the cephalic vein of human subjects (588.1) (2014)

Background Cephalic arch stenosis (CAS) leads to access failure in hemodialysis patients with brachiocephalic fistula. The objective of this study was to use computational fluid dynamic modeling (CFD) to predict wall shear stress (WSS) in fistula access to determine the effects of increased arterial flow in the cephalic arch. Methods A venogram, Doppler and whole blood viscosity were performed pre‐fistula and at 3 months. Geometric measurements of arch angle and vein diameter were made. CFD of the cephalic arch was created to predict wall shear stress throughout the vessel. Results Eleven subjects receiving hemodialysis were studied. The arch angle decreased with a mean average of 133° at baseline to 116° at three months (p = 0.002). The venous diameter increased from 0.26 cm to 0.44 cm (p = 0.002). The blood flow increased from 3.95 cm/sec to 47.14 cm/sec (p &lt; 0.001). A comparison of the CFD streamline plots between baseline and three months showed angle reduction, coupled with high flows leading to flow separation in most cases at three months. Flow separation was associated with a change in flow direction and low WSS. Conclusion Fistula creation results in increased arterial pressure and flow in the native vein. The vein dilates over three months with an observed decrease in [LOCAL] WSS made worse by the acute angulation of the arch, both contributing to intimal hyperplasia and CAS. Grant Funding Source : Supported By: NIH‐NDK 1 RO1 DK090769
Synchrotron Radiation: a Tool for Chemistry and Biology (1982)

Two recent types of application of X-ray synchrotron radiation are reviewed in the context of specific examples. Recent data on the polarization dependent K-edge X-ray absorption spectrum of plastocyanin is presented. Quantum chemistry calculations of this kind of polarization dependence in simpler molecules help with the interpretation of the spectral features. Anomalous diffraction of rare-earth labelled biological membranes form the second example. The specific case considered is of acetylcholine receptor membranes from electric fish.
Internal Oxidation during Intercritical Annealing of CMnSi TRIP Steel (2009)

The equilibrium internal oxidation of CMnSi TRIP steel at intercritical annealing temperatures in a +3°C dew point N2+10%H2 atmosphere was investigated by means of high resolution transmission electron microscopy of cross-sectional samples. The experimental conditions are considered to lead to the selective internal oxidation of Mn and Si. The intercritical annealing however resulted in the formation of three types of isolated particles on the surface: 200–340 nm size single crystal MnO oxide particles, crystalline 30–60 nm size xMnO·SiO2 (1≤x≤4) and amorphous α-xMnO·SiO2 (0<x<0.9) oxide particles. A thin 25–35 nm film of crystalline xMnO·SiO2 (1≤x≤2) was present between these particles. Thin discontinuous transition oxide layers with a thickness of 25–55 nm were formed between the MnO particles and the Fe matrix. The composition of this xMnO·SiO2 layer varied from 1≤x≤2 for crystalline xMnO·SiO2 to 0<x<0.9 for amorphous α-xMnO·SiO2. In the subsurface region, two distinct types of internal oxidation zones were observed. In the first internal oxidation zone, within the 1 μm range below the surface, fine ferrite grains with a grain size of ~550 nm were observed. Crystalline xMnO·SiO2 (1≤x≤2) oxide particles with a diameter of 80–250 nm were present in this internal oxidation zone. In the second internal oxidation zone, from 1 to 4 μm below the surface, the ferrite grain size was about 4 μm, and similar to the grain size in the bulk. Inter-granular amorphous α-SiO2 particles, 180–300 nm in diameter, and an extensive, apparently continuous, grain boundary network of amorphous α-SiO2 were observed in this second internal oxidation zone. The observed oxide distribution is related to the difference in selective oxidation behavior of the main alloying elements Si and Mn and very likely due to the difference in their diffusivities, oxide stability and oxide solubility during intercritical annealing. The decarburization of the matrix during annealing in a high dew point atmosphere is also likely to play a role. The observed selective oxidation is relevant for the continuous galvanizing of high strength steels. It is expected that the presence of a thinner oxide film is less likely to prevent the formation of the inhibition layer and the wetting of the steel surface by the liquid Zn during hot dip galvanizing. Operation of the annealing furnace at a higher dew point during the processing of Si-bearing steels such as conventional CMnSi TRIP steel may therefore lead to a decrease of galvanizing surface defects.
Blockchain and Federated Learning for Privacy-Preserved Data Sharing in Industrial IoT (2019)

The rapid increase in the volume of data generated from connected devices in industrial Internet of Things paradigm, opens up new possibilities for enhancing the quality of service for the emerging applications through data sharing. However, security and privacy concerns (e.g., data leakage) are major obstacles for data providers to share their data in wireless networks. The leakage of private data can lead to serious issues beyond financial loss for the providers. In this article, we first design a blockchain empowered secure data sharing architecture for distributed multiple parties. Then, we formulate the data sharing problem into a machine-learning problem by incorporating privacy-preserved federated learning. The privacy of data is well-maintained by sharing the data model instead of revealing the actual data. Finally, we integrate federated learning in the consensus process of permissioned blockchain, so that the computing work for consensus can also be used for federated training. Numerical results derived from real-world datasets show that the proposed data sharing scheme achieves good accuracy, high efficiency, and enhanced security.
Improved methods of estimating shape from shading using the light source coordinate system (1989)

Abstract This paper develops improved methods of estimating local surface orientation from shading information with the aid of a coordinate system having one axis in the (assumed) direction of the light source. In this system, the surface tilt is related to the direction of the gray level gradient at the given point. An alternative formulation of the surface slant probability density is developed that takes the discrete nature of digital images into account, and that yields a better estimate of the light source direction.
Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke (2015)

In the treatment of acute ischemic stroke (AIS), vessel recanalization correlates with improved functional status and reduced mortality. Mechanical neurothrombectomy achieves a higher likelihood of revascularization than intravenous thrombolysis (IVT), but there remains significant discrepancy between rates of recanalization and rates of favorable outcome. The poor neurological recovery among some stroke patients despite successful recanalization confirms the need for adjuvant therapy, such as pharmacological neuroprotection. Prior clinical trials of neuroprotectant drugs failed perhaps due to inability of the agent to reach the ischemic tissue beyond the occluded artery. A protocol that couples mechanical neurothrombectomy with concurrent delivery of a neuroprotectant overcomes this pitfall. Activated protein C (APC) exerts pleiotropic anti-inflammatory, anti-apoptotic, antithrombotic, cytoprotective, and neuroregenerative effects in stroke and appears a compelling candidate for this novel approach.
Chaos in a two-spin system with applied magnetic field (1998)

We observe both classical and quantum chaos in a system of two interacting magnetic moments in an applied magnetic field. Chaos in the classical system, as seen in the Poincar\'e surface of section, and chaos in the quantum system, as indicated by the changing patterns of the quantum web, appear at the same value of the applied magnetic field parameter. The signatures of chaos disappear in both the classical and quantum systems at a larger value of the field parameter.
Monolithic intrinsic Coincident polarimeter using organic photovoltaics (2018)

Polarimeters have broad applications in remote sensing, astronomy, and biomedical imaging to measure the emitted, reflected, or transmitted state of polarization (SOP). An Intrinsic Coincident full-Stokes Polarimeter (ICP) was previously demonstrated by our group, in a free space configuration, by using stain-aligned polymer-based organic photovoltaics (OPVs). These were tilted to avoid back-reflection cross-talk. In this paper, we present a theoretical model of a monolithic ICP which considers the back-reflection’s influence. This includes a comparison between the free space model to the new monolithic model. Experimental demonstrations yield less than 3% error between our model and the experiment data.
Descemet Membrane Endothelial Keratoplasty—Reply (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
HLA‐DQB1*05:66:01, a novel variant of HLA‐DQB1*05, identified in a Singaporean Malay bone marrow donor (2020)

Nucleotide substitutions in codon 38 of HLA-DQB1*05:03:01:01 result in a novel allele, HLA-DQB1*05:66:01.
Towards an improvement of citrus canker control in Reunion island (1999)

Citrus industry in Reunion started in the 1960s, with introduction of propagating plant material from countries where citrus bacterial canker disease (CBCD) had never been reported. CBCD possibly occurred in Reunion at that time on wild citrus trees in Creole gardens. Control of CBCD in nurseries can potentially improve disease control in new grove planting, as infected plants would be the main source of primary inoculum. Development of diagnostic tools. #Xanthomonas axonopodis# pv.#citri# (#Xac#), associated with infected nursery citrus, is a target of international phytosanitary quarantine. A sensitive and specific detection technique of #Xac# was developed allowing detection of approximately 102 cells per gram of citrus leaf. Climatic conditions in Reunion and spread of #Xac# in groves and nurseries. In most citrus growing areas in Reunion, year-round temperatures and annual rainfalls are conducive to infection by #Xac#. Spatiotemporal analyses of CBCD in simulated nurseries. Spatial and spatio-temporal studies confirmed that disease patterns were aggregated in the field over time. Increase of disease rates was greater in plots with overhead irrigation, and, in the case of plots with drip irrigation, it was associated with natural rainfall.To minimize CBCD transmission to new grove, a modernization scheme for local citrus plant production was proposed. Durability of a clean planting stock strategy. Grapefruit plants produced according to this improved scheme have been planted under various environmental conditions to experimentally determine the durability of citrus canker control resulting from the use of disease-free plants combined with other integrated control measures. Conclusion The improvement of the citrus nursery production scheme will essentially benefit citrus cultivars of low or moderate susceptibility to CBCD
Immunotherapy for Pancreatic Cancer (2012)

Patients with pancreatic cancer have an especially poor prognosis, with a 5-year survival rate of <1% and a median survival of 4-6 months (Jemal, Siegel et al., 2010). The management of patients with pancreatic cancer depends on the extent of the disease at diagnosis. However, approximately 80% of patients present with advanced-stage disease that precludes surgical resection (pancreaticoduodenectomy) and long-term survival is poor (Sener, Fremgen et al., 1999). Even after resection, the majority of patients relapse, leading to a median survival of about 18 months after resection (Neoptolemos, Stocken et al., 2004). In this time, gemcitabine-based chemotherapy is typically offered as standard of care. However, most patients treated with gemcitabine alone do not survive longer than 6 months, as the tumor cells are naturally resistant to current chemotherapy (Neoptolemos, Stocken et al., 2004). Importantly, the tumors that develop gemcitabine resistance would still be a suitable target for immunotherapy. Therefore, cancer immunotherapy for pancreatic cancer may be one attractive approach to treatment. This chapter summarizes the effect of immunotherapy for inducing cytotoxic T lymphocytes (CTLs) in patients with pancreatic cancer and discusses recent advances in concept of combination therapy of immunotherapy and chemotherapy.
Los conflictos de la sede episcopal de Ourense en la Edad Media (ss. XII-XIII) (2003)

Restaurada definitivamente despues del colapso provocado por la invasion musulmana, la sede episcopal de San Martin de Ourense se configura a lo largo de los siglos XII y XIII como un importante centro de poder en el sureste del territorio galaico. Donaciones, compraventas, permutas o privilegios de todo tipo convierten a los obispos aurienses en notables figuras no solo en el ambito eclesiastico, sino tambien en el economico, en el socio-politico y en el cultural. Pero ese poder tiene que ser defendido, conservado y, en la medida de lo posible, aumentado. Esto originara una amplia serie de conflictos a los que se vera abocada la Iglesia auriense frente a otras instituciones y personas. El objetivo basico de este trabajo es precisamente trazar un panorama de esta variada y compleja conflictividad que protagonizara la sede de Ourense en estos dos primeros siglos que siguen a su definitiva restauracion.
Analysis on Wheel Load Variation in Coupled Motion Between Running Wheel and Track with Irregularity (2007)

The decrease of wheel load variation is effective in enhancing stability, safety of high-speed train. In this paper, we conduct the simulation analysis on wheel load variation in order to figure out the mechanism of wheel load variation in consideration of track irregularity such as sine wave and to investigate the influence of the relation between unsprung mass and static wheel load. As a result, we figured out as follows : The wheel load variation at high speed increases according as the wheel speed because the vertical inertia force of wheel increases widely by high-speed running along the flexible rail with irregularity. If sleeper passing frequency and the irregularity passing frequency is close to the primary natural frequency of the wheel/rail system, the wheel load variation becomes larger. The decrease of wheel mass is very effective in decreasing the wheel load variation in comparison with the decrease of static wheel load.
Carrier Ethernet: Providing the Need for Speed (2008)

Facilitating high data transfers over long distances at a reasonable cost, Carrier Ethernet is solidifying its fundamental position as the core of next-generation networks. Since it first dazzled the IT world 40 years ago with its ability to move data over local networks, Ethernet has dramatically evolved in both form and function. And now, Carrier Ethernet, flexing its multi-gigabit muscle, is rapidly emerging as the undisputed technology of choice. As engaging as it is comprehensive, this volume Examines the differences between the so-called flavors of Ethernet Provides refreshers on virtual LANs (VLANs), virtual private networks (VPNs), and Multi-Protocol Label Switching (MPLS) Details Carrier advantages over other modalities with regard to network performance Delves into Service Level Agreements, including ways to obtain a quality of service for the movement of voice and real-time video, as well as the creation of VLANs to facilitate the movement of data Describes various services that can be enabled over an Ethernet infrastructure All You Need to Know about this Carrier-Class System Ensuring seamless migration to Carrier Ethernet from existing technologies, as well as integration with emerging services, this text provides readers with the expert guidance needed to make full use of Ethernet technology, both now and into the future.
ChemInform Abstract: A NEW SYNTHESIS OF PYRAZOFURIN (1981)

Abstract Durch Diazotierung und anschließende Neutralisation erhält man aus dem Pyrazolderivat (I) das kristalline Diazopyrazol (II), das bei der Photolyse in das Pyrazol (III) übergeht.
Supplementary Data from Transcriptional Profiles Predict Disease Outcome in Patients with Cutaneous T-Cell Lymphoma (2023)

Supplementary Data from Transcriptional Profiles Predict Disease Outcome in Patients with Cutaneous T-Cell Lymphoma
Solvent-Free Strategy To Encapsulate Degradable, Implantable Metals in Silk Fibroin (2018)

Implantable electronics hold enormous clinical potential for diagnosis and treatment of neurodegenerative and cardiac diseases and abnormalities. Transient devices are attractive alternatives to conventional silicon electrodes, as they can provide short-term electrical stimulation/recording followed by complete device degradation, mitigating the need for removal surgeries. Packaging transient metals is inherently challenging as they degrade upon contact with aqueous conditions. Development of new transient metal packaging strategies is a critical step toward transient device development. In this fundamental work, a solvent-free compression molding approach to encapsulate magnesium, a resorbable metal, in silk fibroin protein is reported. Silk fibroin was selected because of its processing versatility, desirable mechanical properties, compatibility with biological environments, and controllable degradation behavior in aqueous environments. The silk/magnesium composites were fabricated via compression molding, followed by water annealing to modify the secondary structure of the silk protein matrix to tune physical properties. Transient composite properties as a function of water annealing time are presented, which elucidate synergies between silk physical properties and degradation kinetics of the encapsulated magnesium, information useful in the design of multifunctional, transient metal-based constructs.
Climate change resilience of Melbourne (2012)

Extract:\nScience indicates that climate change is occurring, and represents a global risk which demands an urgent multilateral response. The high uncertainty in the range of possible outcomes of climate change stresses the need for immediate strategic action. Whilst international efforts in responding to climate change are strong, the role of both private enterprise and local governments in planning and implementing local enterprises is also important. Local and state government agencies in Victoria are well known for their progressive programs toward climate change resilience. Consequently it was decided to focus the review within this region where three questions were raised regarding initiatives supporting resilience to climate change.\n1. What are the potential climate change risks for metropolitan Melbourne?\n2. What are some of the major climate change initiatives of local councils in metropolitan Melbourne?\n3. Are the identified government policies effective in light of the climate change risks identified within the scope of this study?\nThe greater metropolitan Melbourne area has a population figure of approximately 4.1 million.\nBy 2030, Melbourne is projected to become Australiaâs largest city.
Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma (2020)

Abstract Recent developments in immuno-oncology demonstrate that not only cancer cells, but also features of the tumor microenvironment guide precision medicine. Still, the relationship between tumor and microenvironment remains poorly understood. To overcome this limitation and identify clinically relevant microenvironmental and cancer features, we applied single-cell RNA sequencing to lung adenocarcinomas. While the highly heterogeneous carcinoma cell transcriptomes reflected histological grade and activity of relevant oncogenic pathways, our analysis revealed two distinct microenvironmental patterns. We identified a prognostically unfavorable group of tumors with a microenvironment composed of cancer-associated myofibroblasts, exhausted CD8+ T cells, proinflammatory monocyte-derived macrophages and plasmacytoid dendritic cells (CEP 2 pattern) and a prognostically favorable group characterized by myeloid dendritic cells, anti-inflammatory monocyte-derived macrophages, normal-like myofibroblasts, NK cells and conventional T cells (MAN 2 C pattern). Our results show that single-cell gene expression profiling allows to identify patient subgroups based on the tumor microenvironment beyond cancer cell-centric profiling.
Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients (2019)

A growing number of studies has shed light on the role of the NF-κΒ in non-small-cell lung cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative pathway, we investigated the relationship between NF-κΒ2, RelB, NIK and Bcl3 expression (mRNA and protein) and the clinical outcome of NSCLC patients. NF-κΒ2, RelB, NIK and Bcl3 protein expression levels were assessed by immunohistochemistry in tissue samples from 151 NSCLC patients who had curative resection. mRNA levels were also evaluated in 69 patients using quantitative real-time PCR. Although all studied proteins were overexpressed in NSCLC (P < 0.001 for all), only RelB mRNA levels were strongly increased in cancerous specimens compared to tumor-adjacent non-neoplastic tissues (P = 0.009). Moreover, NF-κB2, RelB and Bcl3 expression was associated with overall survival (OS). In particular, cytoplasmic and mRNA expression of RelB was related to 5-year OS (P = 0.014 and P = 0.006, respectively). Multivariate analysis also showed that Bcl3 expression (nuclear and cytoplasmic) was associated with increased 5-year OS (P = 0.002 and P = 0.036, respectively). In addition, higher Bcl3 mRNA levels were associated with inferior OS in stages I & II and improved OS in stages III and IV after 5-year follow-up (P = 0.004 and P = 0.001, respectively). Furthermore, stage I patients with lower NF-κB2 mRNA levels had better 5-year survival in univariate and multivariate analysis (P = 0.031 and P = 0.028, respectively). Interestingly, RelB expression (cytoplasmic and mRNA) was inversely associated with relapse rates (P = 0.027 and P = 0.015, respectively), while low NIK cytoplasmic expression was associated with lower relapse rates (P = 0.019). Cytoplasmic NIK expression as well as NF-κB2/ Bcl3 detection was associated with lymph node infiltration (P = 0.039 and P = 0.014, respectively). The present study confirms the deregulation of the NF-κB alternative pathway in NSCLC and also demonstrates the importance of this pathway in prognosis, recurrence and infiltration of regional lymph nodes.