gebhart/patrepeval huggingface dataset:
Forward flight analysis of slatted rotors using Navier-Stokes methods (1996)

The objective of this study is to evaluate the aerodynamic effects of leading-edge slats on rotor blades under high-speed forward- ight conditions. A partial-span leading-edge slat is proposed for the inboard portion of the existing UH-60A rotor. Some two-dimensional slat studies are done to optimize the slat orientation at low subsonic Mach numbers. A multizone unsteady three-dimensional compressible Navier ­ Stokes solver is developed to compute such rotor/slat con gurations. The rotor wake is captured from  rst principles. Some forward- ight results are presented for the UH-60A slatted rotor and compared with the baseline rotor case. The surface pressures and the force coef cients indicate that the slat is bene cial in reducing the retreating side dynamic stall. It was found that the slat reduces the torque and pitching moments on the retreating side compared to the baseline con guration.
Two-year Carcinogenicity Study in Rats with a Nonnucleoside Reverse Transcriptase Inhibitor (2014)

Administration of lersivirine, a nonnucleotide reverse transcriptase inhibitor, daily by oral gavage to Sprague-Dawley rats for up to 2 yr was associated with decreased survival, decreased body weights, and an increase in neoplasms and related proliferative lesions in the liver, thyroid, kidney, and urinary bladder. Thyroid follicular adenoma and carcinoma, the associated thyroid follicular hypertrophy/hyperplasia, hepatocellular adenoma/adenocarcinoma, altered cell foci, and hepatocellular hypertrophy were consistent with lersivirine-related induction of hepatic microsomal enzymes. Renal tubular adenoma and renal tubular hyperplasia were attributed to the lersivirine-related exacerbation of chronic progressive nephropathy (CPN), while urinary bladder hyperplasia and transitional cell carcinoma in the renal pelvis and urinary bladder were attributed to urinary calculi. Renal tubular neoplasms associated with increased incidence and severity of CPN, neoplasms of transitional epithelium attributed to crystalluria, and thyroid follicular and hepatocellular neoplasms related to hepatic enzyme induction have low relevance for human risk assessment.
Rapid DNA hybridization based on ac field focusing of magnetically labeled target DNA (2005)

Rapid DNA-DNA hybridization between surface-bound probe DNA and magnetically labeled complementary target DNA was achieved using current carrying line structures and oscillating external magnetic fields. Magnetic particles of 250 nm in diameter were focused and manipulated over on-chip U-shaped current lines using dc currents of 40 mA and oscillating magnetic fields of 1.4kA∕mrms with frequencies ranging from 0.1 to 20 Hz. The focusing process was both time and frequency dependent and, consequently, hybridization degree varied with focusing efficiency. Extensive label binding was observed in 5–25 min at 0.1–20 Hz. This technique has strong potential in commercial DNA chip development.
Changing sexual behaviours amongst MSM during the COVID-19 restrictions in Wales: a mixed methods study (2022)

The COVID-19 pandemic and associated restrictions had a significant impact on sexual behaviours among MSM in Wales, with the majority fully adhering to the lockdown rules. Although the population were largely compliant with the lockdown restrictions, lockdown fatigue may suggest that any future lockdowns might not have the same effect.
Analysis of the local seismic hazard for the stability tests of the main bank of the Po river (Northern Italy) (2014)

This paper presents the methodology and the results of the local seismic analyses, performed in the bank areas of the Po River (Lombardia and Emilia-Romagna regions, northern Italy) characterized by the highest seismic hazard and finalized for the seismic stability analyses of the banks themselves. The proposed methodology includes the following steps: collection of the pre-existing information and geologic maps; deployment of in-situ investigations by collecting soil samples for geotechnical laboratory tests; definition of the geologic-geophysical and geotechnical model; individuation of the expected seismic inputs; analyses of local seismic response. In this paper, we mainly discuss the results obtained in order to illustrate how the methodology employed enables the definition of the local seismic hazard and allows performing the future stability analyses of the banks. The results are given in term of amplification factors, expected accelerograms and acceleration response spectra modified by the litho-stratigraphic characteristics of the sites.
The U.S. Department of Energy-Office of Environmental Management's International Program (2007)

The U.S. Department of Energy's (DOE) Office of Environmental Management (EM) has collaborated with the various international institutes (e.g. Russian Federal Atomic Energy Agency--Rosatom and Ukraine government's Chornobyl Center-International Radioecology Laboratory (CC-IRL)) for many years on radioactive waste management challenges of mutual concern. Currently, EM is cooperating with Rosatom and the Ukraine's CC-IRL to explore issues related to high-level waste and to investigate experience and technologies that could support EM site cleanup needs. EM is currently implementing five collaborative projects with other international institutes on nuclear waste issues: (1) Application of the Cold Crucible Induction Heated Melter to DOE Wastes; SIA Radon, Moscow. (2) Design Improvements to the Cold Crucible Induction Heated Melter; Electrotechnical University, St. Petersburg. (3) Improve Retention of Radionuclides in Cement Type Waste Forms; Khlopin Radium Institute, St. Petersburg. (4) Improved Solubility and Retention of Troublesome Components in SRS and Hanford HLW Glasses; Khlopin Radium Institute, St. Petersburg. (5) Long-term Impacts from Radiation/Contamination within the Chornobyl Exclusion Zone, Chornobyl Center, International Radioecology Laboratory, Ukraine The purpose of this paper is to provide an overview of EM's objectives for participating in cooperative activities with various international institutes. Additionally, this paper presents programmatic and technical information on these activities, and outlines specific technical collaborations currently underway and planned to support DOE's cleanup and closure mission.
A resource management framework for interactive Grids (2004)

Abstract Traditional use of Grid computing systems has been for batch jobs in the scientific and academic computing. We envision the next generation Grid computing systems to support graphical interactive sessions. In this paper, we propose a resource management framework for supporting graphical interactive sessions in a Grid computing system. We describe the high‐level architectural resource management framework distributed among the submission node, central scheduler node, and the execution node. We then describe in detail the resource management framework on the execution node. The description of the resource management framework on the scheduler node is kept at a high level in this paper. The framework on execution nodes consists of Resource Management Agents, an Admission Control system and Application Predictor system. The agents on the execution node are Startup Agents, Sensor Agents, Monitoring Agents, Aggregator Agents, Enforcement Agents and Registration Agents. The Session Admission Control system is responsible for determining if a new application session can be admitted to the execution node. An Application Predictor system is responsible for predicting the resource utilization behavior of applications based on data obtained from the Resource Management Agents. The proposed framework allows for implementation of a scalable and extensible middleware for interactive Grid resource management. It supports fine‐grained performance guarantees specified in service level agreements and brings forth some important and novel contributions to enable graphical interactive sessions on Grids. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Molecularly-doped polyurethane foams with massive piezoelectric response (2016)

We report a new piezoelectric design scheme and flexible polyurethane foams with <italic>d</italic><sub>33</sub> piezocoefficients up to 244 ± 30 pC N<sup>−1</sup>. Doping nonpolar polymers with polar molecules creates highly polar materials, while mesostructures yield advantageous mechanical properties for piezoelectric response.
ChemInform Abstract: Stereoselective Hydride Reductions of Cyclic α,β‐Unsaturated N‐Diphenylphosphinyl Imines to Protected Allylic Amines. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested in a physiological hip joint simulator. (2001)

Osteolysis and loosening of artificial joints caused by UHMWPE wear debris has prompted renewed interest in metal-on-metal (MOM) hip prostheses. This study investigated the wear and wear debris morphology generated by MOM prostheses in a physiological anatomical hip simulator for different carbon content cobalt chrome alloys. The low carbon pairings demonstrated significantly higher "bedding in" and steady state wear rates than the mixed and high carbon pairings. The in vitro wear rates reported here were up to one or two orders of magnitude lower than the clinical wear rates for first-generation MOM hip prostheses. Two methods for characterising the metal wear debris were developed, involving digestion, scanning electron microscopy and transmission electron microscopy. The metal wear particles characterised by the two methods were similar in size, 25-36 nm, and comparable to particles isolated from periprosthetic tissues from first and second-generation MOM hip prostheses. Due to the small size of the metal particles, the number of particles generated per year for MOM prostheses in vitro was estimated to be up to 100 times higher than the number of polyethylene particles generated per year in vivo. The volumetric wear rates were affected by the carbon content of the cobalt chrome alloy and the material combinations used. However, particle size and morphology was not affected by method of particle characterisation, the carbon content of the alloy or material combination.
Pre and post-grafting immunological and clinical factors influencing the survival of a second kidney transplant. An one center study. (1998)

570 Patients awaiting a second kidney transplant are more and more numerous on the lists as 10 to 15 years after the introduction of CsA, given the calculated half life of a renal transplant under CsA, at least 50% of the patients transplanted in the eighties will require dialysis again. These transplantations are also more difficult to perform, as most of the recipients have developed high titers of panel reactive antibodies (PRA). We have analyzed, in a population of 202 consecutive recipients of a 2nd renal transplant, all grafted at the same institution over the last 12 years, the pre and post-grafting, clinical and immunological factors that significantly influenced graft survival. All patients received the same immunosuppressive protocol, a quadruple sequential induction therapy based on ATG or a monoclonal antibody, and a maintenance treatment with CsA bi or triple therapy. Mean PRA before transplantation was 41 +/- 36% and 29% of the patients were hyperimmunized. Patient survival was 92% and graft survival (GS) 68% at 10 years. Duration of first transplantation, the cause of first graft loss and the degree of pre transplant immunization did not appear to have a significant impact on the outcome of the 2nd transplant. A high HLA matching between donor and recipient was the most important factor, resulting in significantly higher GS (p<0.03) in patients having <= 2 mismatches (MM) vs >=3 MM, whatever the pre-graft immunization. Clinical parameters predictive of bad long term GS were the occurrence of a first acute rejection(33% of the patients) (p<0.01) and delayed graft function, defined as dialysis requirement in the 1st week post-transplant (p<0.05) or as the length of the period with creatinine clearance <10 ml/mn (p<0.006). This study indicates that with a high HLA matching, good results can be achieved in second transplantations receiving an induction treatmentbased on ATG and indeed, allograft survival in retransplantations is as high as in first transplantations in our center.
Improvement in Thermal Stability of Stacked Structures of Aluminum Nitride and Lanthanum Oxide Thin Films on Si Substrate (2007)

films were deposited as capping (deposited on top of) and reaction barrier layers (placed between the Si substrate and film) to improve the thermal stability of films. The film structures were investigated by high-resolution transmission electron microscopy and angle-resolved X-ray photoelectron spectroscopy. The -capped film did not change its structure after thermal annealing, while that with the barrier films showed a slight increase in the film thickness. The Al atoms diffuse onto the film surface during annealing in the stack, which makes the bottom barrier layer less effective than the capping layer.
Proteomic Surveillance of Autoantigens in Relapsing Polychondritis (2006)

Relapsing polychondritis (RP) is a systemic inflammatory disease, in which autoimmunity to cartilage-related components is thought to be involved in its pathogenesis. However, the autoimmune profile in RP has not been studied fully. We therefore investigated autoantibodies/autoantigens in RP comprehensively, by 2-dimensional electrophoresis (2DE), subsequent western blotting (WB) and mass spectrometry, using cell-extracted proteins as the antigen source. As a result, we detected 15 autoantigens on 2DE-WB, and further identified five of them. On average, one RP serum recognized approximately 8 out of the 15 autoantigens. Frequencies of the autoantibodies to the 5 identified antigens of tubulin alpha ubiquitous/6, vimentin, alpha enolase, calreticulin, and colligin-1/-2 were 91%, 46%, 36%, 82%, and 36%, respectively. ELISA using recombinant proteins for them revealed that frequencies of the autoantibodies to tubulin alpha ubiquitous, vimentin, alpha enolase, calreticulin, and colligin-1 were 36%, 64%, 46%, 27%, and 18%, respectively. Our data demonstrated that the autoimmune reaction was not restricted to cartilagerelated components, rather a variety of autoimmune responses occurred in patients with RP, which may be involved in the pathophysiology of RP. In addition, the proteomic approach using cell-extracted proteins would be a powerful way to investigate autoantigens.
Mutagenicity of 12 HPLC Labeling Reagents for Analysing Carboxyl Compounds. (1997)

実験室内で用いられる化学物質の使用や廃棄に伴う安全性評価の一環として, HPLCラベル化剤の変異原性をSalmonella typhimurium TA 98とTA100を用いて±S9mix条件下, プレインキュベーション法で調べた。調べた化合物は, カルボキシル基用のHPLCラベル化剤, 1-benzyl-3-p-tolyltriazene [BTT] , 1-p-nitrobenzyl-3-p-tolyltriazene [NBTT] , N-chloromethyl phthalimide [CMP] , N-chloromethyl-4-nitrophthalimide [CMNP] , 9-chloromethylanthracene [CMA] , O- (p-nitrobenzyl) -N, N'-diisopropylisourea [NBDI] , phenacyl bromide [PB] , p-phenylphenacyl bromide [PPB] , p-bromophenacyl bromide [BPB] , m-methoxyphenacyl bromide [MPB] , 7-acetoxy-4-bromomethylcoumarin [BrMAC] および4-bromomethyl-7-methoxycoumarin [BrMMC] の12種類である。これらのHPLCラベル化剤のー変異原性試験の結果, BTT, NBTT, CMP, CMNP, CMA, NBDIの6種は, NBDIのTA98に対する変異原性を除いて, TA100およびTA98両方の菌株に対して-S9条件下で強い変異原性を示した。4種のphenacyl bromides [PBs] をacetoneを溶媒として試験を行った際には明確な変異原性は認められなかったが, DMSOを溶媒として試験した際には, 4種のPBsともTA100の-S9条件下において変異原性を示した。これは, PBsが溶媒のDMSOにより酸化されたため, TA100の-S9条件下で強い変異原性を示すphenylglyoxalが生成したためと考えられる。BrMACおよびBrMMCは, PBsと同様にラベル化部位に臭素を持つが, DMSOとacetoneのどちらを溶媒として用いた場合にも変異原性は認められなかった。
Indices of ovulation: comparison of plasma and salivary levels of progesterone with urinary pregnanediol (1984)

An increased daily excretion of pregnanediol, relative to that early in the menstrual cycle, is often taken to be evidence that a woman has ovulated. This paper assesses the value of alternative procedures for this purpose. Urine, plasma and saliva samples were collected during a 24-h period from 20 women during the follicular phase and from 20 women during the luteal phase. The 24-h excretion of pregnanediol was compared with (1) the concentration of progesterone in plasma, (2) the concentration of progesterone in saliva, (3) the concentration of pregnanediol in small urine samples, (4) the rate of excretion of pregnanediol and (5) the ratio of pregnanediol to creatinine in small urine samples. Each analyte increased substantially during the luteal phase. The median increases (ratio of luteal to follicular phase values) were 14.8, 3.2, 10.6, 11.9 and 11.1 respectively. By comparison, the median increase in 24-h pregnanediol output was 9.2. When the other analytes were used instead of the 24-h excretion of pregnanediol to assess the possibility of ovulation, the incidence of misclassifications (follicular samples classed as luteal and luteal samples classed as follicular) was 0, 12.8, 5.9, 2.0 and 1.0% respectively. It was concluded that the most satisfactory alternative to the measurement of 24-h pregnanediol output for the biochemical assessment of ovulation based on progesterone production was the measurement of the concentration of progesterone in plasma; the least satisfactory alternative was determination of the concentration of progesterone in saliva. If blood was not available, measurement of the ratio of pregnanediol to creatinine in a small urine sample was the preferred method.
Disjoint-Access Parallelism (2015)

Disjoint-Access Parallelism (DAP) is considered one of the most desirable properties to maximize the scalability of Transactional Memory (TM). This paper investigates the possibility and inherent cost of implementing a DAP TM that ensures two properties that are regarded as important to maximize efficiency in read-dominated workloads, namely having invisible and wait-free read-only transactions. We first prove that relaxing Real-Time Order (RTO) is necessary to implement such a TM. This result motivates us to introduce Witnessable Real-Time Order (WRTO), a weaker variant of RTO that demands enforcing RTO only between directly conflicting transactions. Then we show that adopting WRTO makes it possible to design a strictly DAP TM with invisible and wait-free read-only transactions, while preserving strong progressiveness for write transactions and an isolation level known in literature as Extended Update Serializability. Finally, we shed light on the inherent inefficiency of DAP TM implementations that have invisible and wait-free read-only transactions, by establishing lower bounds on the time and space complexity of such TMs.
Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I‐BAR proteins (2012)

Dewetting is the spontaneous withdrawal of a liquid film from a non-wettable surface by nucleation and growth of dry patches. Two recent reports now propose that the principles of dewetting explain the physical phenomena underpinning the opening of transendothelial cell macroaperture (TEM) tunnels, referred to as cellular dewetting. This was discovered by studying a group of bacterial toxins endowed with the property of corrupting actomyosin cytoskeleton contractility. For both liquid and cellular dewetting, the growth of holes is governed by a competition between surface forces and line tension. We also discuss how the dynamics of TEM opening and closure represent remarkable systems to investigate actin cytoskeleton regulation by sensors of plasma membrane curvature and investigate the impact on membrane tension and the role of TEM in vascular dysfunctions.
Repeat Administration Elicits a Practice Effect With the Balance Error Scoring System but Not With the Standardized Assessment of Concussion in High School Athletes. (2003)

OBJECTIVE: To assess whether repeated administration of the Standardized Assessment of Concussion (SAC) and Balance Error Scoring System (BESS) demonstrates a practice effect in high school athletes. DESIGN AND SETTING: Subjects were assigned to either a control or practice group. Subjects in the control group were assessed twice, 30 days apart. Subjects in the practice group were assessed on 5 occasions. Four assessments were performed within a 7-day period and 1 more assessment 30 days after the initial test. SUBJECTS: Thirty-two uninjured high school athletes participated in this investigation. Sixteen were randomly assigned to a control group and 16 to a practice group. MEASUREMENTS: We measured performance on the SAC and on 6 test conditions of the BESS. RESULTS: We found a significant time-by-group interaction on BESS performance on the day-30 test session. A significant practice effect of the BESS was found during the course of repeated administrations in the practice group. After repeated testing, the number of BESS errors decreased with each test session, and error scores on day 5 (10.94 +/- 2.17) and day 7 (9.44 +/- 3.32) were significantly lower than the baseline score (12.88 +/- 3.34). We did not find group differences or a practice effect on the SAC (baseline score = 26.16). CONCLUSIONS: Our results revealed no practice effect with the SAC and a slight practice effect with repeated administrations of the BESS, especially with the single-leg stance on foam. Clinicians must acknowledge the potential for practice effects when readministering these concussion assessments to track recovery of an athlete or as a guide in return-to-play decision making.
P47 Inherited Familial Thrombocytopenia due to an Autosomal Dominant Mutation in the Cytoplasmic Domain of Platelet β3‐Integrin that is Associated with the Expression of Activation‐Dependent Epitopes (2006)

Background Glanzmann's Thrombasthenia (GT) and Bernard Soulier Syndrome (BSS) are the two most common inherited forms of thrombasthenia. They are caused by alterations in expression or function of integrin alphaIIb/β3 or glycoprotein (GP) Ib/IX/V respectively. We identified an individual with chronic mild macrothrombocytopenia (range 59–100 × 10 9 L −1 ) but no overt bleeding diathesis. The propositus was found to have atypical binding of monoclonal antibodies (mAb) to β3 integrin and increased expression of GPIbVIX. Methods and Results The exons and flanking intronic sequences of ITGB3, ITGA2B GPIBA, GPIBB, GP9 and GP5 genes were sequenced. Heterozygous, non‐synonymous single nucleotide polymorphisms (SNP) were identified in the ITGB3 and the GPIBA genes. These result in the substitution of Histidine for Aspartate at residue 723 (D723H) in ITGB3 and Leucine for Proline at residue 69 (P69L) in GPIBA. Asp723 in ITGB3 is known to form a critical salt‐bridge with ITGA2B and charge reversal at residue 723 causes constitutive activation of the integrin in vitro . In agreement with this, mutant alphaIIb/β3‐His723 expressing CHO cell lines showed an increased expression of activation dependent epitopes relative to wild‐type as measured by mAb PAC‐1 binding. Increased PAC‐1 binding was also observed on resting platelets of affected individuals compared with non‐affected family members. Further investigation of three generations of the propositus’ family identified several individuals with both SNPs each of whom had an identical platelet phenotype. However, in the one family member identified who carried the GPIBA mutation alone, normal platelet size and count were observed suggesting that the ITGB3 D723H substitution is the causative mutation. Genotyping a panel of 1127 unrelated controls for the two SNPs identified five individuals with the GPIBA mutation and none with the ITGB3 mutation. Conclusions We report a novel autosomal dominant cause of a mild form of macrothrombocytopenia caused by a D723H substitution in the beta3 integrin. We postulate that the low platelet count is due to increased consumption of platelets due to enhanced levels of surface expressed, activated GPIIbIIIa.