gebhart/patrepeval huggingface dataset:
Sequence Requirements of the ATP-Binding Site within the C-Terminal Nucleotide-Binding Domain of Mouse P-Glycoprotein:  Structure−Activity Relationships for Flavonoid Binding (2001)

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain (NBD2) of mouse P-glycoprotein were investigated by using two recombinantly expressed soluble proteins of different lengths and photoactive ATP analogues, 8-azidoadenosine triphosphate (8N(3)-ATP) and 2',3',4'-O-(2,4,6-trinitrophenyl)-8-azidoadenosine triphosphate (TNP-8N(3)-ATP). The two proteins, Thr(1044)-Thr(1224) (NBD2(short)) and Lys(1025)-Ser(1276) (NBD2(long)), both incorporated the four consensus sequences of ABC (ATP-binding cassette) transporters, Walker A and B motifs, the Q-loop, and the ABC signature, while differing in N-terminal and C-terminal extensions. Radioactive photolabeling of both proteins was characterized by hyperbolic dependence on nucleotide concentration and high-affinity binding with K(0.5)(8N(3)-ATP) = 36-37 microM and K(0.5)(TNP-8N(3)-ATP) = 0.8-2.6 microM and was maximal at acidic pH. Photolabeling was strongly inhibited by TNP-ATP (K(D) = 0.1-5 microM) and ATP (K(D) = 0.5-2.7 mM). Since flavonoids display bifunctional interactions at the ATP-binding site and a vicinal steroid-interacting hydrophobic sequence [Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J.-M., Barron, D., and Di Pietro, A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 9831-9836], a series of 30 flavonoids from different classes were investigated for structure-activity relationships toward binding to the ATP site, monitored by protection against photolabeling. The 3-OH and aromaticity of conjugated rings A and C appeared important, whereas opening of ring C abolished the binding in all but one case. It can be concluded that the benzopyrone portion of the flavonoids binds at the adenyl site and the phenyl ring B at the ribosyl site. The Walker A and B motifs, intervening sequences, and small segments on both sides are sufficient to constitute the ATP site.
Induction of DT-Diaphorase in Riboflavin-Deficient Rats by Xenobiotic Treatment. (1996)

This paper describes the induction of DT-diaphorase by xenobiotic treatment of riboflavin-deficient rats. Upon injection of β-naphthoflavone once a day for 3 successive days into male Wistar rats fed a riboflavin-supplemented diet for 4 weeks, the activity of DT-diaphorase in the cytosolic, mitochondrial, and microsomal fractions of rat liver increased several fold compared with that of the vehicle control. In the case of rats fed a riboflavin-deficient diet for 4 weeks, DT-diaphorase activity in the cytosolic fraction was markedly decreased and that in microsomes was somewhat diminished, whereas the activity in mitochondrial fraction did not change, compared with that of the above control. However, when the deficient rats were injected with β-naphthoflavone intraperitoneally, DT-diaphorase activity in the cytosolic, mitochondrial, and microsomal fractions increased in spite of a significant decrease in flavin levels in the body. These results indicate that DT-diaphorase is actually induced even under conditions of riboflavin deficiency and that the apoprotein of the enzyme takes up FAD to become holoenzyme, suggesting a redistribution of FAD among various flavoproteins in the liver of riboflavin-deficient rats upon administration of a xenobiotic. Among the activities of other flavoenzymes examined, the occurrence of the apoenzyme of glutathione reductase, thioredoxin reductase or NADPH-cytochrome P450 reductase was found upon the injection of β-naphthoflavone in the riboflavin-deficient rats, which might be an indication of the above-mentioned redistribution.
Reading Swift (2019)

This new volume of Reading Swift assembles 26 lectures delivered at the Seventh Münster Symposium on Jonathan Swift in June 2017, testifying to an extraordinary spectrum of research interests in the Dean of St Patrick’s, Dublin, and his works. Reading Swift follows the tried and tested format of its predecessors, grouping the essays in eight sections: biographical problems; bibliographical and canonical studies; political and religious as well as philosophical, economic, and social issues; poetry; Gulliver’s Travels; and reception studies. The élan vital, which has been such a distinctive feature of Swift scholar-ship in the past thirty-five years, is continuing unabated.
Cathodoluminescene study of Mg implanted GaN: the impact of dislocation on Mg diffusion (2019)

Magnesium (Mg) ion implanted homoepitaxial GaN layers is investigated by cathodoluminescence (CL) and secondary ion mass spectrometry (SIMS). The impact of dislocations on Mg diffusion is clarified by CL monitoring the Mg-related donor-acceptor pair (DAP) emission on novel angle cutting specimen. CL results suggest that: (1) there exist high concentration of nonradiative defects in a Mg implanted layer; and (2) Mg shows pipe diffusion along threading dislocations throughout epilayer to substrate. To achieve successful Mg doping by ion implantation, it is necessary to suppress the formation of a dead region in the Mg implanted layer and the pipe diffusion along threading dislocations.
Theory of defect states in glassyAs2Se3 (1981)

Structural defects in glassy ${\mathrm{As}}_{2}$${\mathrm{Se}}_{3}$ are classified and labeled according to the constituent like-atom bonds and malcoordinated atoms. A selection rule is formulated to reduce the number of allowed Fermi-level pinning reactions. An elementary Bethe-lattice model is introduced as a starting point for a discussion of the electronic structure of simple defects. The defect states are found to be very different from those in Se; deep gap states arise in ${\mathrm{As}}_{2}$${\mathrm{Se}}_{3}$ because of unique bond orbitals, whereas they occur in Se due to unique $\ensuremath{\pi}$ interactions between orbitals. Malcoordinated Se atoms are expected to give rise to hydrogenic levels in ${\mathrm{As}}_{2}$${\mathrm{Se}}_{3}$, in contrast to Se. Surprisingly, the undercoordinated pnictide defects are positively charged in this model. Finally, defect creation energies and densities at ${T}_{g}$ are discussed.
Improvements to the Johnson noise thermometry system for measurements at 505 - 800 K (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation K. Yamazawa, W. L. Tew, A. Pollarolo, H. Rogalla, P. D. Dresselhaus, S. P. Benz; Improvements to the Johnson noise thermometry system for measurements at 505 - 800 K. AIP Conf. Proc. 11 September 2013; 1552 (1): 50–55. https://doi.org/10.1063/1.4819514 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
References (2019)

Data quality is one of the most important problems in data management, since dirty data often leads to inaccurate data analytics results and incorrect business decisions. Poor data across businesses and the U.S. government are reported to cost trillions of dollars a year. Multiple surveys show that dirty data is the most common barrier faced by data scientists. Not surprisingly, developing effective and efficient data cleaning solutions is challenging and is rife with deep theoretical and engineering problems. This book is about data cleaning, which is used to refer to all kinds of tasks and activities to detect and repair errors in the data. Rather than focus on a particular data cleaning task, we give an overview of the endto- end data cleaning process, describing various error detection and repair methods, and attempt to anchor these proposals with multiple taxonomies and views. Specifically, we cover four of the most common and important data cleaning tasks, namely, outlier detection, data transformation, error repair (including imputing missing values), and data deduplication. Furthermore, due to the increasing popularity and applicability of machine learning techniques, we include a chapter that specifically explores how machine learning techniques are used for data cleaning, and how data cleaning is used to improve machine learning models. This book is intended to serve as a useful reference for researchers and practitioners who are interested in the area of data quality and data cleaning. It can also be used as a textbook for a graduate course. Although we aim at covering state-of-the-art algorithms and techniques, we recognize that data cleaning is still an active field of research and therefore provide future directions of research whenever appropriate.
Correction: Corrigendum: Anatomical Characteristics and Biomechanical Properties of the Oblique Popliteal Ligament (2017)

Scientific Reports 7: Article number: 42698; published online: 16 February 2017; updated: 10 April 2017 This Article contains an error in the Discussion section. “Even so, there remains an area without external support between the OPL, the expansion over the popliteus muscle, and the lateral side ofthe posterior cruciate ligament, which are strongly related to the formation of popliteal cysts”.
Positional Cloning of the Chediak-Higashi Syndrome Gene: Genetic Mapping of the beige locus on Mouse Chromosome 13 (1996)

These studies indicate that a genomic rearrangement affecting Nid or Estm9 does not underlie bg. The bg locus has been localized on mouse Chromosome 13 with sufficient precision to enable rapid cloning of the bg non-recombinant interval and eventual identification of the gene for Chediak-Higashi syndrome among sequences within the interval.
Neural networks and nonparametric regression (2003)

The problem of estimating an unknown function from a finite number of noisy data points is a problem of fundamental importance for many applications in signal processing, machine vision, pattern recognition, and process control. Recently, several new computational techniques for nonparametric regression have been proposed by statisticians and by researchers in artificial neural networks. The author presents a critical survey and a common taxonomy of statistical and neural network methods for regression. Global parametric methods, piecewise parametric or locally parametric methods, and adaptive computation methods are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A texttiling based approach to topic boundary detection in meetings (2006)

Our goal is to automatically detect boundaries between discussions of different topics in meetings. Towards this end we adapt the TextTiling algorithm [1] to the context of meetings. Our features include not only the overlapped words between adjacent windows, but also overlaps in the amount of speech contributed by each meeting participant. We evaluate our algorithm by comparing the automatically detected boundaries with the true ones, and computing precision, recall and f–measure. We report average precision of 0.85 and recall of 0.59 when segmenting unseen test meetings. Error analysis of our results shows that although the basic idea of our algorithm is sound, it breaks down when participants stray from typical behavior (such as when they monopolize the conversation for too long).
Phase-Field Modeling of Transport-Limited Electrolysis in Solid and Liquid States (2007)

A phase-field model of electrochemical interface dynamics is developed to study cathode shape and topology change in transport-limited electrolysis in two and three dimensions under conditions of rapid charge redistribution. A case study for the binary model is carried out for an Fe–FeO system. Stability behavior of the model is in good agreement with linear stability theory for small amplitude sinusoidal perturbation in electrodeposition. When there is no convection, a high electric field and low surface tension cause the cathode interface to be unstable, leading to growth of dendrites which break into powders. When the electrodes and electrolyte are low-viscosity fluids, flow provides an additional mechanism for stabilizing the interface. A new stability criterion for this liquid situation based on the Schmidt number is derived from dimensional analysis and model results. For an unstable cathode interface, a streamer morphology (liquid dendrites) is observed in two and three dimensions. This binary model is extended to a ternary system and a representative case is carried out for the Ti–Mg–Cl system. One- and two-dimensional ternary simulations show qualitatively correct interface motion and electrical potential behavior.
Roadside safety design for small vehicles (1989)

This report documents and presents the results of a study to evaluate the impact performance of widely used roadside safety elements for a 1,500 lb vehicle and to identify potential modifications that would enable existing roadside safety elements to accommodate a design vehicle weighing as little as 1,250 lb. A full-scale crash test program coupled with an extensive computer analysis study were used to evaluate impact performance. Elements evaluated included the concrete safety shaped barrier (CSSB), the G4(1S) roadside barrier, breakaway luminaire and sign supports, a base-bending sign support, the eccentric-loader guardrail terminal, crash cushions, and roadside safety features including slopes, ditches, driveways, and curbs. It was concluded that: (a) modifications to the CSSB may be needed to mitigate overturn problems; (b) performance of the G4(1S) is satisfactory; (c) performance of most slip-base, breakaway supports is satisfactory but the frangible transformer base is not acceptable; (d) a single 4 lb/ft steel U-post sign support is marginally acceptable; (e) the eccentric-loader guardrail terminal is not acceptable but with modifications, it could possibly be made acceptable; (f) the sand-filled plastic drum crash cushion can be easily designed to accommodate a 1,300 lb vehicle; (g) although no apparent modifications are needed for slope, ditch, and driveway designs, more overturns can be expected with the small vehicle if these features are not constructed and maintained so as to avoid poorly compacted, eroded, and irregular terrain; and (h) to minimize small car overturn, AASHTO curb types C, E, and G, or similar designs are preferred.
Genetically restricted and unrestricted antigen specific helper factors (1982)

Some human antigen specific helper factors (HF) derived from long term human T helper cell lines are genetically restricted in their action. Other human HF's, derived from 4-6 day cultures, are capable of activating mouse spleen cell cultures, and hence are not xenogeneically restricted. While it is possible that these results suggest a heterogeneity of HF, we have also found that some long term lines make both antigen specific HF and non specific factors. In this case the whole supernatant appears unrestricted but specific, suggesting a possible explanation for the variable degree of genetic restriction.
A fully integrated real-time multi-tasking knowledge-based system: application to an on-board diagnostic system (2003)

A flexible software architecture is required to allow problem solving in dynamic real-time situations. Such an architecture is described. It is based on a knowledge-based development system, SUPER, and a real-time multi-tasking kernel which gives to the knowledge-based system the ability to perform data input, interrupt handling, and temporal reasoning during the inference process. Methods are provided which allow the system to be responsive to important events and to focus attention dynamically. It is possible to generate a source code from the knowledge base. This code can be compiled and linked to external procedures. The application of the system to the development of an integrated real-time diagnostic system, embedded in a car, which computes its capacity to execute a maneuver safely, is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Note—A Counterexample in Continuous Markov Decision Chains (1974)

Results in another paper in this issue may raise the question of whether for finite state and action, continuous time parameter Markov decision chains there always exists an initially stationary optimal policy. We give an example in which there is do such policy.
ABA and polyamines act independently in primary leaves of  cold‐stressed tomato (Lycopersicon esculentum) (2002)

The effects of ABA and putrescine, a polyamine, on cold-induced membrane leakage were investigated using primary leaves of wild-type and an ABA-deficient mutant, flacca, of tomato (Lycopersicon esculentum Mill.). The amount of chilling-induced electrolyte leakage from flacca leaves was much higher than that from the wild-type leaves. When applied exogenously ABA reduced cold-induced electrolyte leakage from leaves of both wild-type and the flacca mutant. However, the cold-induced electrolyte leakage from flacca leaves was not as pronounced as in the wild-type indicating that ABA is an important mediator in response to cold stress in the leaves. Putrescine reduced cold-induced electrolyte leakage from both wild-type and flacca leaves. Synthesis of putrescine in the leaves was increased by cold treatment. DFMO, a biosynthetic inhibitor of the polyamine, increased electrolyte leakage from cold-treated leaves, and exogenously applied putrescine decreased the enhanced leakage to the control level. Therefore, this polyamine is thought also to be involved in the response to cold stress of tomato leaves. Both ABA and putrescine were protective against cold stress, but exogenously applied ABA decreased the endogenous level of putrescine in the leaves. Furthermore, the DMFO-increased electrolyte leakage in cold-stressed leaves was completely abolished by the application of ABA. These results suggest that ABA is a major regulator in the response to cold stress in tomato leaves and that it does not exert its role via putrescine in the response to cold stress.
RATIONALLY-DESIGNED SURFACE NANOPATTERNING: A POTENTIALLY NEW MEANS FOR ENHACING SAFETY & EFFICACY OF VASCULAR STENTS (2008)

This paper presents preliminary data supporting the feasibility of an innovative new therapeutic strategy that seeks to address the limitations of current drug-eluting stents via rational design of stent surface topography at the nanoscale. Using recentlydeveloped anisotropic metal micromachining techniques, we have created bulk metal substrate surfaces patterned with arrays of micrometer to sub-micrometer scale parallel grooves. The rationale for this pattern geometry is based upon the presumption that such features will facilitate healing by accelerating reestablishment of the endothelium, the native lining of the vessel wall. Results from our preliminary in vitro studies show that these surfaces accelerate endothelialization, promote more native cellular morphology, and significantly enhance competitive adhesion of endothelial cells over vascular smooth muscle cells. As such, these data suggest that rationally-designed nanopatterned surfaces may provide a robust new means for enhancing efficacy and safety of vascular stents, possibly without the need for drug-elution.
Effect of UV radiation and pro‐oxidant on PP biodegradability (2008)

Abstract The effect of ultraviolet exposure on the biodegration of poly(propylene) without (PP) and with 0.3 (wt/wt) (PPOx) pro‐oxidant additives, produced by extrusion was studied. After UV exposure the samples were submitted to biodegradation (weight loss) in prepared soils. The samples before and after UV exposure were analyzed using differential scanning calorimetry, Fourier transform infrared spectroscopy, size exclusion chromatography, and optical microscopy. The exposure to UV radiation lead to more intense degradation of PPOx than of PP; the amount of carbonyl groups was larger for the PPOx samples than for PP, as well as the decrease in the T m and in the molecular weight. The samples exposed to UV radiation showed some level of fragmentation after 56 days when placed in the prepared soil; the samples which were exposed to UV for 480 h presented just a small weight loss. POLYM. ENG. SCI., 2009. © 2008 Society of Plastics Engineers
Myostatin Gene Mutated Mice Induced with TALE Nucleases (2015)

Myostain gene (MSTN) is expressed primarily in skeletal muscle, and negatively regulates skeletal muscle mass; it has been suggested that mice with MSTN inhibition have reduced adiposity and improved insulin sensitivity. Therefore, it is important to establish a fast and effective gene editing method. In this report, we established the myostatin mutated-mouse model by microinjection of Transcription Activator-Like Effector Nucleases (TALENs) mRNA within the mouse fertilized oocytes and achieved high rates of mutagenesis of the mouse MSTN in C57BL/6J. Six of 45 born mice carried target mutations and we appointed one as the parental mating with wild mouse to produce the F1 and backcross to produce the F2 generation. All the mutations of the mice were examined quickly and efficiently by high-resolution melting curve analysis (HRMA) and then verified by direct sequencing. We obtained the homozygous of the F2 generation which transmitted the mutant alleles to the progeny with 100% efficiency. Mutant mice exhibited increases in muscle mass comparable to those observed in wild-type mice. Therefore, combining TALEN-mediated gene targeting with HRMA technology is a superior method of constructing genetically modified mice through microinjection in the mouse fertilized oocytes with high efficiency and short time of selection.
Nonlinear equalization for data storage channels (2002)

Nonadditive and non-Gaussian noises and nonlinear signal distortions are significant sources of error in high density digital magnetic recording. Transition noise, transition broadening and partial erasure are a few such impediments. We propose a multilayer perceptron (MLP) based nonlinear equalizer to counter such distortions. It is shown that for realistic channel models the performance of such a nonlinear equalizer is superior to that of the conventional linear partial response equalizer, when used with a Viterbi detector.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Host-guest chemistry: macrocyclic hosts and non-metallic guests (1989)

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Downregulation in GATA4 and Downstream Structural and Contractile Genes in the db/db Mouse Heart (2012)

Reduced expression of GATA4, a transcriptional factor for structural and cardioprotective genes, has been proposed as a factor contributing to the development of cardiomyopathy. We investigated whether the reduction of cardiac GATA4 expression reported in diabetes alters the expression of downstream genes, namely, atrial natriuretic peptide (ANP), B-type natriuretic, peptide (BNP), and α- and β-myosin heavy chain (MHC). db/db mice, a model of type 2 diabetes, with lean littermates serving as controls, were studied. db/db mice exhibited obesity, hyperglycemia, and reduced protein expression of cardiac GLUT4 and IRAP (insulin-regulated aminopeptidase), the structural protein cosecreted with GLUT4. Hearts from db/db mice had reduced protein expression of GATA4 (~35%) with accompanying reductions in mRNA expression of ANP (~40%), BNP (~85%), and α-MHC mRNA (~50%) whereas expression of β-MHC mRNA was increased by ~60%. Low GATA4 was not explained by an increased ligase or atrogin1 expression. CHIP protein content was modestly downregulated (27%) in db/db mice whereas mRNA and protein expression of the CHIP cochaperone HSP70 was significantly decreased in db/db hearts. Our results indicate that low GATA4 in db/db mouse heart is accompanied by reduced expression of GATA4-regulated cardioprotective and structural genes, which may explain the development of cardiomyopathy in diabetes.