gebhart/patrepeval huggingface dataset:
Nerve growth factor: activation of the classical complement pathway by specific substitution for component C1-. (1982)

The interaction of homogeneous preparations of mouse submandibular gland nerve growth factor (NGF) with the classical complement pathway was studied. NGF was found to be capable of carrying out the enzyme activities of the first component (C1-) of the classical complement pathway (i.e., the cleavage of zymogen C4 and C2). NGF would not substitute for any other classical pathway component, C2-C9. The C1(-)-like activity of NGF was inhibited by human C1- inactivator. This interaction of NGF with the complement system may account for the previously described ability of NGF to accelerate the rate of contraction of experimentally induced wounds.
Poster Abstract: Federated Learning for Speech Emotion Recognition Applications (2020)

Privacy concerns are considered one of the major challenges in the applications of speech emotion recognition (SER) as it involves the complete sharing of speech data, which can bring threatening consequences to people’s lives. Federated learning is an effective technique to avoid privacy infringement by involving multiple participants to collaboratively learn a shared model without revealing their local data. In this work, we evaluated federated learning for SER using a publicly available dataset. Our preliminary results show that speech emotion recognition can benefit from federated learning by not exporting sensitive user data to central servers, while achieving promising results compared to the state-of-the-art.
ChemInform Abstract: Synthesis of 3‐Aryl‐4‐acetyl‐1H‐pyrazolo(3,4‐b)pyridines and 3‐Aryl‐4‐acetyl‐1H‐pyrazolo(4,3‐c)pyridines. (1990)

Abstract Lithiation of the 2‐chloropyridin‐4‐yl ketone acetal (I) followed by coupling with the aromatic aldehydes (II) yields the carbinols (III) which are subjected to Swern oxidation, forming the 2‐chloro‐3‐aroylpyridines (IV).
Voice-Enabled User Interfaces for Mobile Devices (2008)

The use of a voice interface, along with textual, graphical, video, tactile, and audio interfaces, can improve the experience of the user of a mobile device. Many applications can benefit from voice input and output on a mobile device, including applications that provide travel directions, weather information, restaurant and hotel reservations, appointments and reminders, voice mail, and e-mail. We have developed a prototype system for a mobile device that supports client-side, voice-enabled applications. In fact, the prototype supports multimodal interactions but, here, we focus on voice interaction. The prototype includes six voice-enabled applications and a program manager that manages the applications. In this chapter we describe the prototype, including design issues that we faced, and evaluation methods that we employed in developing a voice-enabled user interface for a mobile device.
Wide‐Field Optical Microscopy of Microwave Fields Using Nitrogen‐Vacancy Centers in Diamonds (2016)

Real-time wide-field optical microscopy and spectroscopy of microwave fields is demonstrated using nitrogen-vacancy (NV) centers in diamonds. By monitoring electron spin dependent fluorescence of NV centers under a continuous illumination, a microwave field is imaged with an amplitude sensitivity of ≈45 nT Hz−1/2 and a frequency sensitivity of 2.5 kHz Hz−1/2, across a 200 × 200 μm2 imaging area with submicrometer spatial resolution. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dephosphorization of 40% Iron Melt with CaO-based Flux Containing CaF<SUB>2</SUB>-CaCl<SUB>2</SUB> and CaCl<SUB>2</SUB> (1983)

Iron melt of 4% C was treated with CaO based flux containing CaF2-CaCl2 and CaCl2 additives by using a rotating crucible containing 1 kg metal at 1 350°C, and the dephosphorization reaction and its important donimant factors were studied. The transport of phosphorous occurred between slag and metal.The experimental results were explained by assuming the following equation of dephosphorization reaction :[P]+3/2 (O2-)+5/4 O2=(PO43-)Apparent distribution ratio, Lp(≡(P)/[P]), was strongly dependent on oxygen partial pressure, PO2, slag basicity, B, and additive contents.Lp in air was given experimentally as follows :B≤1.2 logLp=2.04+8.69 logB+εi·NAdd.less than or ezualB>1.2 logLp = 2.75+εi·NAdd.where B=NCaO/(2NSiO2+3NP2O5)NAdd: mole fraction of additiveNAdd=0.150.5εCa(F, Cl)2=0.74, andεCaCl2= 2.91Lp and overall reaction rate constant of phosphorous, kp, increased as PO2 increased.
Inhibition of Galectins with Small Molecules (2011)

Evidence that the galectin family of proteins plays crucial roles in cancer, inflammation, and immunity has accumulated over the last decade. The galectins have consequently emerged as interesting drug targets. A majority of galectin functions occurs by means of cross-linking glycoproteins and by doing so controlling glycoprotein cellular localization and residence times. The glycoprotein cross-linking occurs when galectin dimers or multimers, or galectins with two binding sites, bind galactose-containing glycans of the glycoproteins. Such galectin-glycan interactions have been successfully blocked with compounds having multivalent presentation of galactose, lactose, or N-acetyllactosamine, with peptides, and with small carbohydrate (galactose) derivatives. This review summarizes and analyzes attempts to develop efficient and selective small-molecule galectin inhibitors through derivatization of monosaccharides, mainly galactosides, with non-carbohydrate structures that protrude into subsites adjacent to the core-conserved galactose-recognizing site of the galectins.
Chemoselective deprotection of 1-O-acyl sugar derivatives (1989)

Etude par voltammetrie, polarographie de la reduction du bis-(chlorodiphenylstannyl) methane
Ambulatory perineural infusion: the patients' perspective (2003)

This investigation suggests that perineural local anesthetic infusion is generally well tolerated by ambulatory patients.
Pd/NHC-Catalyzed Enantiospecific and Regioselective Suzuki–Miyaura Arylation of 2-Arylaziridines: Synthesis of Enantioenriched 2-Arylphenethylamine Derivatives (2014)

A palladium-catalyzed stereospecific and regioselective cross-coupling of enantiopure 2-arylaziridines with arylboronic acids under mild conditions to construct a tertiary stereogenic center has been developed. N-heterocyclic carbene (NHC) ligands efficiently promote the coupling, suppressing β-hydride elimination. The enantiospecific cross-coupling allowed us for preparation of a series of biologically important 2-arylphenethylamine derivatives in an enantiopure form.
New Applications Using White LED for Frontlighting (2005)

&lt;div class="htmlview paragraph"&gt;In the field of exterior lighting within the automobile, the light emitting diode (LED) is becoming more and more significant. While benchmarking the existing products of different LED suppliers it becomes clear that especially in the area of frontlighting applications, it only makes sense to use high-power LEDs. Taking the different concepts of connecting technologies for thermal management, driver electronics required to efficiently handle the necessary power and the influence of luminous flux vs. luminance of these new light sources into consideration (to name only some aspects of this complex matter) this article will sketch the present state-of-the-art and give an outlook into the future.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;LED development is currently in a critical phase which is focussing on the area of frontlighting alongside the signal lamp range which has been gaining a foothold for some years already. Via the signal functions side marker light, position light and daytime running light, first applications have been already successfully realised in different headlamps.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Only a few years ago, the use of high-power LEDs in headlamps was inconceivable. - Today not only the technical pre-conditions are given for this technology, it also has the system advantages which make it predestined for this particular function. This means that the greatest obstacles for its introduction are primarily only the question of its economic feasibility in addition to achievement of approval.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Without doubt these obstacles can be overcome. When the continually increasing efficiency of LEDs and the simultaneous reduction in costs for the emitters are considered, it must be assumed that this technology will be used on a larger scale in the foreseeable future.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;An important task for the future remains the development of LEDs, suitable for automotive applications for the meaningful realisation of main lighting functions while at the same time cutting costs.&lt;/div&gt;
Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease (2022)

Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation in ischemic muscle disease. Methods: Caspase activity was measured in ischemic and perfused human myoblasts in response to the NLRP3 and AIM2 inflammasome agonists (nigericin and poly(dA:dT), respectively) with and without specific caspase-1 or pan-caspase inhibition. mRNA levels of myogenic markers and caspase-1 were assessed, and protein levels of caspases-1, -4, -5, and -3 were measured by Western blot. Results: When compared to perfused cells, ischemic myoblasts demonstrated attenuated MyoD and myogenin and elevated caspase-1 mRNA. Ischemic myoblasts also had significantly higher enzymatic caspase activity with poly(dA:dT) (p < 0.001), but not nigericin stimulation. Inhibition of caspase activity including caspase-4/-5, but not caspase-1, blocked activation effects of poly(dA:dT). Ischemic myoblasts had elevated cleaved caspase-5. Inhibition of caspase activity deterred differentiation in ischemic but not perfused myoblasts and reduced the release of HMGB1 from both groups. Conclusion: Inflammatory caspases can be activated in ischemic myoblasts by AIM2 and influence ischemic myoblast differentiation and release of pro-angiogenic HMGB1. AIM2 inflammasome involvement suggests a role as a DNA damage sensor, and our data suggest that caspase-5 rather than caspase-1 may mediate the downstream mediator of this pathway.
An immunological and electrophoretic comparison of the thylakoids from vegetative cells and heterocysts ofAnabaena cylindrica (1977)

An antiserum prepared to Triton-solubilized thylakoid membranes isolated from the vegetative cells of Anabaena cylindrica cross-reacts in the Ouchterlony double immunodiffusion test to produce four precipitin bands with the homologous antigens. Solubilized heterocyst thylakoids only react to produce two bands with the above antiserum. The antiserum also produced a heavier total immunoprecipitation with vegetative cell thylakoids than with similar amounts of heterocyst thylakoid proteins. The immunological evidence that the vegetative cell thylakoids contain proteins which are either not present in heterocysts, or become modified during heterocyst differentiation, is supported by differences in the polypeptide compositions of the membranes from the two cell types. Sodium dodecyl sulphate (SDS)—solubilization followed by SDS acrylamide gel electrophoresis revealed 13 bands in the vegetative thylakoid samples but only eight with the heterocyst material. No polypeptide molecular weight species were present in the heterocyst samples which were not also present in the vegetative cell membranes, suggesting that de novo thylakoid synthesis during heterocyst differentiation, previously proposed from electron microscopy studies, must only involve the formation of molecular weight classes of polypeptides already present in the vegetative cells.
A new advanced approach to the design of combustion chambers in diesel engines (2006)

An innovative methodology aimed at reducing emissions and improving fuel consumption has been developed for the design of internal combustion engines. The method allows the design of new combustion chambers by means of a fully automated procedure based on computational fluid dynamics (CFD) simulations, genetic algorithms and clustering. Four different engine operating conditions, i.e. load and speed values, were considered in the design of the combustion chamber. The results of the optimisation were used to understand the effect of the five geometrical parameters on the mechanism of formations of soot and NOx by analysing the distribution of temperature and equivalence ratio within the optimised chambers.
Cell surface-associated proteins which bind native type IV collagen or gelatin. (1984)

Gelatin coupled to Sepharose has been used to isolate [35S]methionine-labeled polypeptides of Mr = 47,000, 56,000, 62,000, and 65,000 from the 12,000 X g supernatant of detergent extracts of mouse embryo parietal endoderm cells. The polypeptides can also be recovered from various established cell lines which synthesize type IV procollagen, and in these cells the Mr = 47,000 polypeptide is the major gelatin-binding component. Several lines of evidence, including the results of continuous labeling and pulse-chase experiments, show that the polypeptides are not derived by proteolytic cleavage of larger precursors and are distinct from fragments of fibronectin. The Mr = 47,000, 62,000, and 65,000 polypeptides all contain N-linked oligosaccharide side chains, as judged by their labeling with [3H]mannose and their sensitivity to tunicamycin. The Mr = 62,000 and 65,000 polypeptides can be resolved by two-dimensional gel electrophoresis into species with different isoelectric points, and the Mr = 47,000 has a pI of 7.5-8.0. None of the gelatin-binding polypeptides appear to accumulate in the culture medium, and the Mr = 47,000, 62,000, and 65,000 species are labeled in a lactoperoxidase-catalyzed iodination of intact cells, suggesting that they are associated with the cell surface. Only the Mr = 47,000 glycoprotein binds to native type IV collagen. Possible functions for these surface components in vivo are discussed.
Molar ratio of In to urea directed formation of In2O3 hierarchical structures: cubes and nanorod-flowers (2011)

In this work, different morphologies of In2O3 products were fabricated by the calcination of In(OH)3, which was synthesized through a hydrothermal route, with tuning of the molar ratio of indium to urea. The In2O3 inherited the morphology of its precursor and the proposed formation mechanisms for the In(OH)3 structures, assisted by the molar ratio of indium to urea, were put forward. The formation mechanism of In(OH)3 cubes at a higher molar ratio of In to urea was ascribed to Ostwald ripening mechanism, while the growth of In(OH)3 nanorod-based flowers at a lower molar ratio of In to urea was attributed to the oriented attachment of In(OH)3 nanoparticles coordinated with the complexation of In3+ to urea, in which the urea may play ternary roles including being the alkaline media, the coordinating agent and the surface anchored organic molecules.
MODELING THE FLYBY ANOMALIES WITH DARK MATTER SCATTERING (2010)

We continue our exploration of whether the flyby anomalies can be explained by scattering of spacecraft nucleons from dark matter gravitationally bound to the earth. We formulate and analyze a simple model in which inelastic and elastic scatterers populate shells generated by the precession of circular orbits with normals tilted with respect to the earth's axis. Good fits to the data published by Anderson et al. are obtained.
Motion based object tracking in MPEG-2 stream for perceptual region discriminating rate transcoding (2001)

Object based bit allocation can result in significant improvement in the perceptual quality of relatively low bit-rate video. In this paper we describe a novel content aware video transcoding technique that can accept high-level description of video objects and extract them from incoming video stream and use it for perceptual encoding based extreme video downscaling.
Forty Years of Clathrin‐coated Vesicles (2015)

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin-mediated trafficking is regulated and how the machinery evolved.
Actor-Critic Fictitious Play in Simultaneous Move Multistage Games (2018)

International audience
Approximate multiplication of nearly sparse matrices with decay in a\n fully recursive distributed task-based parallel framework (2019)

In this paper we consider parallel implementations of approximate\nmultiplication of large matrices with exponential decay of elements. Such\nmatrices arise in computations related to electronic structure calculations and\nsome other fields of computational science. Commonly, sparsity is introduced by\ndropping out small entries (truncation) of input matrices. Another approach,\nthe sparse approximate multiplication algorithm [M. Challacombe and N. Bock,\narXiv preprint 1011.3534, 2010] performs truncation of sub-matrix products. We\nconsider these two methods and their combination, i.e. truncation of both input\nmatrices and sub-matrix products. Implementations done using the Chunks and\nTasks programming model and library [E. H. Rubensson and E. Rudberg, Parallel\nComput., 40:328-343, 2014] are presented and discussed. We show that the\nabsolute error in the Frobenius norm behaves as $O\\left(n^{1/2} \\right), n\n\\longrightarrow \\infty $ and $O\\left(\\tau^{p/2} \\right), \\tau \\longrightarrow\n0,\\,\\, \\forall p &lt; 2$ for all three methods, where $n$ is the matrix size and\n$\\tau$ is the truncation threshold. We compare the methods on a model problem\nand show that the combined method outperforms the original two. The methods are\nalso applied to matrices coming from large chemical systems with $\\sim 10^6$\natoms. We show that the combination of the two methods achieves better weak\nscaling by reducing the amount of communication by a factor of $\\approx 2$.\n
Novel Oral Anticoagulants (2010)

Patients undergoing surgery receive anticoagulation for perioperative thromboprophylaxis or ischemic cardiovascular disease. Because anticoagulants may also potentiate bleeding, clinicians need to understand the implications of anticoagulation in perioperative and postoperative patient management. Many newer anticoagulants that are now available or are in clinical development do not require routine coagulation monitoring, have more predictable dose responses, and have fewer interactions with other drugs and food. The most advanced oral anticoagulants in clinical development are the direct factor Xa inhibitors rivaroxaban and apixaban, and the direct thrombin inhibitor dabigatran etexilate. These agents have been evaluated in the postoperative setting in patients undergoing total hip- or knee-replacement surgery with promising results, and it remains to be seen whether these results will translate into other surgical settings. The impact of the new agents will be influenced by the balance between efficacy and safety, improved convenience, and potential cost-effectiveness benefits.
Short Communication Association between Insulin-Like Growth Factor-I:Insulin-Like Growth Factor-Binding Protein-1 Ratio and Metabolic and Anthropometric Factors in Men and Women (2004)

Several prospective observational studies have suggested that elevated circulating IGF-I levels are associated with an increased risk of cancer. These observations may provide a potential mechanism through which previously identified metabolic and anthropometric factors, such as obesity and elevated insulin and glucose levels, may operate. We therefore examined metabolic and anthropometric influences on circulating levels of insulinlike growth factor-I (IGF-I), insulin-like growth factorbinding protein-1 (IGFBP-1), and the IGF-I:IGFBP-1 ratio in a middle-aged population of 349 men and 492 women. IGF-I showed only modest inverse associations with indices of adiposity. However, we found that low IGFBP-I levels and an increased IGF-I:IGFBP-1 ratio were strongly associated with increased levels of insulin and glucose in men and women. Body mass index was also positively related to the IGF-I:IGFBP-1 ratio in men (P < 0.001) and women (P < 0.001), independent of metabolic correlates of IGFBP-1 and IGF-I. Similarly, waist:hip ratio and waist circumference were also associated with an increased IGF-I:IGFBP-1 ratio and low circulating IGFBP-1 levels. These findings suggest that individuals with greater fat mass and upper body obesity may have elevated levels of bioavailable or free IGF-I, which could, in part, mediate the reported associations among metabolic and anthropometric factors and cancer risk.
Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen (1995)

Macrophage inflammatory protein-2 (MIP-2) is a member of a family of cytokines that play roles in inflammatory, immune, and wound healing responses. To clone the cDNA for rat MIP-2, RNA was isolated from the lungs of Fischer 344 rats after instillation of lipopolysaccharide. Reverse transcription-polymerase chain reaction was performed by using synthetic oligonucleotide primers designed from the mouse MIP-2 cDNA sequence. A cDNA containing the coding region of rat MIP-2 was cloned and sequenced. Comparison to the mouse MIP-2 cDNA demonstrated 90.3% homology at the nucleotide level and 86% homology at the amino acid level. The rat MIP-2 cDNA was expressed in Escherichia coli and protein evaluated for bioactivity. The recombinant rat MIP-2 was chemotactic for rat neutrophils but did not stimulate migration of rat alveolar macrophages or human peripheral blood eosinophils or lymphocytes. In addition, the recombinant rat MIP-2 and the related rat chemokine, KC/CINC stimulated proliferation of rat alveolar epithelial cells but not fibroblasts in vitro.
Research of the Data Mining Engine Based on Big Data (2020)

With the rapid development of Internet technology, people are accumulating more and more data, and the scale of data has risen from the previous GB level to IB or even PB. In order to discover the potential value in the data, it is common practice to flexibly use various data mining algorithms according to the actual situation. Although data mining has been fully utilized and developed on traditional small data sets, proving its value and guiding significance, on large data sets, the implementation of data mining algorithms faces execution efficiency, algorithm parallelism, and easy platform Usability challenges. In order to solve the problems of data mining in big data, the paper researches the data mining engine under big data, using Spark as the core engine, and based on Spark's memory computing operators, a number of traditional data mining The parallel computing of the algorithm enables the traditional data mining algorithms to run in parallel in a cluster environment, and thus is well applied in big data. Then, through the system layering method, the data mining system is designed in layers to realize a complete big data mining platform.