gebhart/patrepeval huggingface dataset:
Paraoxonase (PON1): from toxicology to cardiovascular medicine. (2005)

Paraoxonase (PON1) is a liver and plasma enzyme most studied because of its ability to hydrolyze the active metabolites of several organophosphorus insecticides. The discovery that PON1 can also metabolize oxidized phospholipids has spurred research on its possible role in coronary heart disease and atherosclerosis. Additionally, its potential roles in metabolizing pharmaceutical drugs and microbial quorum sensing factors are also being explored. PON1 displays several polymorphisms that influence both its level of expression and its catalytic activity, thus determining the rates at which a given individual will detoxify a specific insecticide, metabolize harmful oxidized lipids, and activate or inactivate specific drugs and quorum sensing factors.
[Clinical and genetic analysis of juvenile parkinsonism in Russia]. (2004)

Clinical and genetic analysis of juvenile parkinsonism was performed in 26 sibs from 20 families. Heterogeneity of the disorder was observed. Mutations in the parkin gene (locus PARK2, chromosome 6q25.2-27), with the prevalence of deletions over point mutations, have been identified in 41%. The comparative clinical analyses of patients examined confirmed the phenotypical polymorphism of "parkinopathy". We also showed the absence of asymmetric manifestation--an important and underestimated so far sign of the disease. The results of the study may be considered as a valuable clue to the clinical diagnosis of parkin-related juvenile parkinsonism in Russian population and implemented for mutation screening and medico-genetic counseling of affected families.
QuikSCAT reveals the surface circulation of the Catalina Eddy (2002)

The Catalina Eddy, a small, recurring cyclonic vortex in the ocean off Los Angeles, is of keen interest to local weather forecasters because of the moderating oceanic effect it brings to the city. Its small size and shallow vertical extent have made it difficult to monitor and predict using conventional data. The microwave scatterometer on the QuikSCAT spacecraft has generated high‐resolution surface wind vectors that provide the first visualization of the complete cyclonic flow of the eddy. Moreover, the superior performance of the QuikSCAT scatterometer demonstrates the relative inaccuracy and inconsistency of predictions of the eddy based upon numerical weather prediction models.
Characterization of the E.coli poly(A) polymerase: nucleotide specificity, RNA-binding affinities and RNA structure dependence (2000)

Polyadenylation of RNA molecules in bacteria and chloroplasts has been implicated as part of the RNA degradation pathway. The polyadenylation reaction is performed in Escherichia coli mainly by the enzyme poly(A) polymerase I (PAP I). In order to understand the molecular mechanism of RNA poly-adenylation in bacteria, we characterized the biochemical properties of this reaction in vitro using the purified enzyme. Unlike the PAP from yeast nucleus, which is specific for ATP, E.coli PAP I can use all four nucleotide triphosphates as substrates for addition of long ribohomopolymers to RNA. PAP I displays a high binding activity to poly(U), poly(C) and poly(A) ribohomopolymers, but not to poly(G). The 3'-ends of most of the mRNA molecules in bacteria are characterized by a stem-loop structure. We show here that in vitro PAP I activity is inhibited by a stem-loop structure. A tail of two to six nucleo-tides located 3' to the stem-loop structure is sufficient to overcome this inhibition. These results suggest that the stem-loop structure located in most of the mRNA 3'-ends may function as an inhibitor of poly-adenylation and degradation of the corresponding RNA molecule. However, RNA 3'-ends produced by endonucleolytic cleavage by RNase E in single-strand regions of mRNA molecules may serve as efficient substrates for polyadenylation that direct these molecules for rapid exonucleolytic degradation.
MARTA GANs: Unsupervised Representation Learning for Remote Sensing Image Classification (2017)

With the development of deep learning, supervised learning has frequently been adopted to classify remotely sensed images using convolutional networks. However, due to the limited amount of labeled data available, supervised learning is often difficult to carry out. Therefore, we proposed an unsupervised model called multiple-layer feature-matching generative adversarial networks (MARTA GANs) to learn a representation using only unlabeled data. MARTA GANs consists of both a generative model G and a discriminative model D. We treat D as a feature extractor. To fit the complex properties of remote sensing data, we use a fusion layer to merge the mid-level and global features. G can produce numerous images that are similar to the training data; therefore, D can learn better representations of remotely sensed images using the training data provided by G. The classification results on two widely used remote sensing image databases show that the proposed method significantly improves the classification performance compared with other state-of-the-art methods.
Surface forces in lungs. III. Alveolar surface tension and elastic properties of lung parenchyma (1986)

The bulk modulus and the shear modulus describe the capacity of material to resist a change in volume and a change of shape, respectively. The values of these elastic coefficients for air-filled lung parenchyma suggest that there is a qualitative difference between the mechanisms by which the parenchyma resists expansion and shear deformation; the bulk modulus changes roughly exponentially with the transpulmonary pressure, whereas the shear modulus is nearly a constant fraction of the transpulmonary pressure for a wide range of volumes. The bulk modulus is approximately 6.5 times as large as the shear modulus. In recent microstructural modeling of lung parenchyma, these mechanisms have been pictured as being similar to the mechanisms by which an open cell liquid foam resists deformations. In this paper, we report values for the bulk moduli and the shear moduli of normal air-filled rabbit lungs and of air-filled lungs in which alveolar surface tension is maintained constant at 16 dyn/cm. Elevating surface tension above normal physiological values causes the bulk modulus to decrease and the shear modulus to increase. Furthermore, the bulk modulus is found to be sensitive to a dependence of surface tension on surface area, but the shear modulus is not. These results agree qualitatively with the predictions of the model, but there are quantitative differences between the data and the model.
BRAF V600E Is a Determinant of Sensitivity to Proteasome Inhibitors (2013)

A critical step toward defining tailored therapy in patients with cancer is the identification of genetic interactions that may impair-or boost-the efficacy of selected therapeutic approaches. Cell models able to recapitulate combinations of genetic aberrations are important to find drug-genotype interactions poorly affected by the heterogeneous genetics of human tumors. In order to identify novel pharmacogenomic relationships, we employed an isogenic cell panel that reconstructs cancer genetic scenarios. We screened a library of 43 compounds in human hTERT-HME1 epithelial cells in which PTEN or RB1 were silenced in combination with the targeted knockin of cancer-associated mutations in EGFR, KRAS, BRAF, or PIK3CA oncogenes. Statistical analysis and clustering algorithms were applied to display similar drug response profiles and mutation-specific patterns of activity. From the screen, we discovered that proteasome inhibitors show selectivity toward BRAF V600E-mutant cells, irrespective of PTEN or RB1 expression. Preferential targeting of BRAF-mutant cells by proteasome inhibitors was corroborated in a second BRAF V600E isogenic model, as well as in a panel of colorectal cancer cell lines by the use of the proteasome inhibitor carfilzomib. Notably, carfilzomib also showed striking in vivo activity in a BRAF-mutant human colorectal cancer xenograft model. Vulnerability to proteasome inhibitors is dependent on persistent BRAF signaling, because BRAF V600E blockade by PLX4720 reversed sensitivity to carfilzomib in BRAF-mutant colorectal cancer cells. Our findings indicated that proteasome inhibition might represent a valuable targeting strategy in BRAF V600E-mutant colorectal tumors.
Tocochromanol Profiles in Chlorella sorokiniana, Nannochloropsis limnetica and Tetraselmis suecica Confirm the Presence of 11′-α-Tocomonoenol in Cultured Microalgae Independently of Species and Origin (2022)

11'-α-Tocomonoenol (11'-αT1) is structurally related to vitamin E and has been quantified in the microalgae <i>Tetraselmis</i> sp. and <i>Nannochloropsis oceanica</i>. However, it is not known whether 11'-αT1 is present in other microalgae independent of species and origin. The aim of this study was to analyze the tocochromanol profiles of <i>Chlorella sorokiniana</i>, <i>Nannochloropsis limnetica</i>, and <i>Tetraselmis suecica</i> and to determine if 11'-αT1 is present in these microalgae. Cultured microalgae were freeze-dried and the presence and identity of α-tocomonoenols were confirmed by LC-MS<sup>n</sup> (liquid chromatography coupled to mass spectroscopy) and GC-MS (gas chromatography coupled to mass spectroscopy). Tocochromanol profiles were determined by HPLC-FLD (liquid chromatography with fluorescence detection) and fatty acid profiles (as fatty acid methyl esters; FAME) by GC-MS. As confirmed by LC-MS<sup>n</sup> and GC-MS, 11'-αT1 was the dominant αT1 isomer in cultured microalgae instead of 12'-αT1, the isomer also known as marine-derived tocopherol. αT1 represented less than 1% of total tocochromanols in all analyzed samples and tended to be more abundant in microalgae with higher proportions of polyunsaturated fatty acids. In conclusion, our findings confirm that αT1 is not restricted to terrestrial photosynthetic organisms, but can also accumulate in microalgae of different species, with 11'-αT1-and not the marine-derived tocopherol (12'-αT1)-as the predominant αT1 isomer.
The Imaginary Pareto Front: a helpful Tool for setting Optimisation Problemfor Design of Electromagnetic Devices (2011)

International audience
Prevention of De Novo Hepatitis B in Recipients of Core Antibody-Positive Livers With Lamivudine and Other Nucleos(t)ides (2013)

LAM monoprophylaxis was effective in preventing de novo HBV in the vast majority of recipients over long-term follow-up. Adefovir had a higher rate of de novo infections numerically, whereas tenofovir and entecavir had no cases and may be more effective, but this was limited by a small sample size.
Selective dissolution and recovery of depleted uranium from armor plate. Final report, 26 June 1986-5 May 1987 (1987)

The impacted armor targets used in testing high density armor-piercing ammunition containing depleted uranium (DU) are subject to disposal as low-level radioactive waste. Because of the costs associated with disposal of the entire armor plate and the limited use of secured commercial sites in the future, the U.S. Army is seeking to identify and evaluate new technologies for decontaminating these armor plates. The objectives of this Phase I SBIR program are two-fold, namely: to develop a selective solvent that can decontaminate impacted armor targets containing DU for disposal or recycle, and to identify and characterize technologies that can remove depleted uranium from the solvent for solvent recycle and uranium recovery for easier hazardous-waste disposal.
887. Relation between hyperconjugation and conformation. Part III. Ethyl alcoholysis of some derivatives of diphenylmethyl chloride (1958)

G. Baddeley and M. Gordon, J. Chem. Soc., 1958, 4379 DOI: 10.1039/JR9580004379
Biomedical Digital Signal Processing: C Language Examples and Laboratory Experiments for the IBM PC (1993)

Introduction to computers in medicine electrocardiography signal conversion basics of digital filtering finite impulse response filters infinite impulse response filters integers filters adaptive filters signal averaging data reduction techniques other time and frequency domain techniques QRS filters ECG monitoring systems VLSI in digital signal processing configuring the PC for UW digiscope data acquisition and control routines data acquisition and control - some hints UW digiscope user's manual signal generation finite length register effects commercial DSP systems.
Acetabular Medial Wall Displacement Osteotomy in Total Hip Arthroplasty for Dysplastic Hips (2010)

Purpose: This study evaluated the results of acetabular medial wall osteotomy to reconstruct the acetabulum in dysplastic hip during total hip arthroplasty. Materials and Methods: We clinically and radiologically evaluated 30 hips of 30 patients with secondary hip osteoarthritis caused by congenital hip dislocation or acetabular dysplasia who underwent total hip arthroplasty (THA) between March 1999 and October 2002. The average age of subjects was 46.5 years(17 to 73 years), and the mean follow-up period was 5 years(5.3 to 8.7 years). In 26 cases, a cementless hemispherical acetabular cup was inserted in the true acetabulum; in 4 cases a reinforced ring was inserted. Only 2 hips needed structural bone grafting. Results: The average Harris hip score improved from 56.3 points preoperatively to 93.2 points at the last follow up. Radiographic analysis revealed no aseptic loosening or radiolucent line, and showed stable bony fixation at the true acetabulum. The mean thickness of the medial acetabular wall postoperative was 20.5 mm(10 to 36 mm). Bone union of the medial wall was observed at a mean of four months postoperatively. Conclusion: Acetabular medial wall osteotomy can maintain the integrity of the acetabular medial wall while achieving enhanced acetabular coverage and more normal hip biomechanics.
A XSS Vulnerability Detection Approach Based on Simulating Browser Behavior (2015)

This paper presents a dynamic detection method based on simulating browser behavior, and designs a web crawler based on a headless browser, which can interpret the JavaScript code and retrieve Ajax content to find the hidden injection points in pages, with full consideration of the web pages containing complex scripts under Web 2.0 environment. In implementation, this paper uses dynamic analysis in XSS vulnerability detection by examining the runtime behavior of web application, and decide whether the XSS vulnerability exists with black-box test. The experiment results prove that this method works.
A proposal of a vehicle network using intervehicle transmission method (2001)

Abstract In this paper, a mobile vehicle network is proposed to be utilized for intervehicle communication. A network building method is described based on using spread spectrum communication technique and establishing individual links between each vehicle while combining communication and distance measurement between the vehicles within a defined area. In order to more completely utilize network capability, a new concept of zone is introduced and defined. Along with the explanation of the network building method, the evaluation of practical usage of such networks based on computer simulation techniques is also provided. © 2001 Scripta Technica, Electron Comm Jpn Pt 1, 85(3): 40–50, 2002
Histological and biochemical criteria for objective and early selection of grapevine cultivars resistant to Plasmopara viticola (2015)

Grapevine breeding is the most effective way to create cultivars resistant to downy mildew (Plasmopara viticola), and to reduce the number of fungicide applications. Four criteria, including histological and biochemical analyses, based on the level of different mechanisms of resistance to grapevine downy mildew, were tested on 42 different cultivars. Plantlets were artificially inoculated with downy mildew and the sporangia density was measured spectrophotometrically 6 d after infection. Callose synthesis in stomata and δ- and ε-viniferin levels at the site of infection were recorded 48 h after inoculation. These observations have allowed the 42 cultivars to be divided into 5 groups: very resistant (VR), resistant (R), less susceptible (LS), susceptible (S) and highly susceptible (HS). All 4 criteria have to be applied to assign the resistance level closer to field conditions. This method allows to rapidly evaluate the level of resistance of seedlings to downy mildew thereby leading to a reduction in duration of the breeding program by several years.
LSD1 inhibition: a therapeutic strategy in cancer? (2012)

Pre-clinical data supporting a therapeutic role for LSD1 inhibitors are most encouraging in acute myeloid leukaemia, although optimal dosing strategies and beneficial combinations with other agents remain unclear. Studies making use of potent, selective LSD1 inhibitors active in the nanomolar range are required to establish therapeutic indications in other subtypes of haematological malignancy, and in solid tumours.
Towards autonomic risk-aware security configuration (2008)

Security of a network depends on a number of dynamically changing factors. These include emergence of new vulnerabilities and threats, policy structure and network traffic. Due to the dynamic nature of these factors, identifying security metrics that measure objectively the quality of security configuration pose a major challenge. Moreover, this evaluation must be done dynamically to handle real time changes in the threat toward the network. In this paper, we extend our security metric framework [2] that identifies and quantifies objectively the most significant security risk factors, which include existing vulnerabilities, historical trend of vulnerabilities of remotely accessible services, prediction of potential vulnerabilities for any general network service and their estimated severity and finally propagation of an attack within the network. We have implemented this framework as a user-friendly tool called Risk based prOactive seCurity cOnfiguration maNAger (ROCONA) and showed how this tool simplifies security configuration management using risk measurement and mitigation.
Chiral metamaterial-based microwave sensors (2017)

A significant resonance shift is found in both reflection and transmission coefficients from both parallel and perpendicular excitations in a helical structure. The responses from the perpendicular excitation show better sensitivity than those from the parallel excitation at 480 MHz-560 MHz for 0.2 circumference difference. Additional electromagnetic properties of a helical structure, such as chirality, optical rotatory dispersion and circular dichroism can also further combine to enhance the sensing performance.
An approach of solution to the change-point problem (2013)

We developed a procedure to find change-points which seems both widely applicable and easy to implement on computer. The number of regimes is not needed a priori. Monte Carlo simulations showed that it is efficient also at low sample size. The approach is fully nonparametric and can be applied without knowing the statistical distribution of each subset. Confidence intervals are evaluated by a Monte Carlo simulation and this requires the latter distributions to be given explicitly. These are determined by Kolumogorov-Smirnov one sample goodness-of-fit test applied to all the different sets identified in the change-point analysis. The procedure is presented with a practical application to Gaussian and Poisson series.
Convex Influences (2021)

We introduce a new notion of influence for symmetric convex sets over Gaussian space, which we term "convex influence". We show that this new notion of influence shares many of the familiar properties of influences of variables for monotone Boolean functions $f: \{\pm1\}^n \to \{\pm1\}.$ Our main results for convex influences give Gaussian space analogues of many important results on influences for monotone Boolean functions. These include (robust) characterizations of extremal functions, the Poincaré inequality, the Kahn-Kalai-Linial theorem, a sharp threshold theorem of Kalai, a stability version of the Kruskal-Katona theorem due to O'Donnell and Wimmer, and some partial results towards a Gaussian space analogue of Friedgut's junta theorem. The proofs of our results for convex influences use very different techniques than the analogous proofs for Boolean influences over $\{\pm1\}^n$. Taken as a whole, our results extend the emerging analogy between symmetric convex sets in Gaussian space and monotone Boolean functions from $\{\pm1\}^n$ to $\{\pm1\}$
Functional recovery in photo‐damaged human dermal fibroblasts by human adipose‐derived stem cell extracellular vesicles (2019)

Ultraviolet-B (UVB) irradiation causes imbalance between dermal matrix synthesis and degradation through aberrant upregulation of matrix metalloproteinases (MMPs), which leads to overall skin photoaging. We investigated the effects of extracellular vesicles (EVs) derived from human adipose-derived stem cells (HASCs) on photo-damaged human dermal fibroblasts (HDFs). EVs were isolated from conditioned media of HASCs with tangential flow filtration and characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), western blotting, micro RNA (miRNA) arrays, cytokine arrays and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The effects of EVs on the UVB-irradiated HDFs were evaluated using scratch assay, ELISA and real-time PCR. Microarrays exhibited that EVs are rich in various miRNAs and proteins, and that these EV contents are linked to a broad range of biological functions, including fibroblast proliferation, UV protection, collagen biosynthesis, DNA repair and cell ageing. A scratch assay showed that HASC-EVs enhanced the migration ability of UVB-irradiated HDFs. Real-time RT-PCR and ELISA analyses revealed that the HASC-derived EVs significantly suppressed the overexpression of MMP-1, -2, -3 and -9 induced by UVB irradiation and enhanced the expression of collagen types I, II, III and V and elastin. In particular, tissue inhibitor of metalloproteinase (TIMP)-1 and transforming growth factor (TGF)-β1, which are important factors involved in MMP suppression and ECM synthesis, were upregulated in EV-treated HDFs after UVB irradiation. Overall results suggest that diverse components that are enriched in HASC-derived EVs could act as a biochemical cue for recovery from skin photoaging.
Voltage Disturbance Identification using Neural Network (2022)

Voltage disturbance, as well as other power quality issues which include electromagnetic interference phenomena, are dangerous power quality issues that can cause sensitive equipment to fail, especially in industrial or hospital environments. Identifying voltage disturbance has an important role to mitigate the degradation of power quality disturbances due to their negative impact on the equipment. The Neural network is used to identify voltage disturbance. This paper presents a combination of identification of voltage disturbance by using a neural network with a multipoint measurement method. This method simplifies the identification of voltage disturbance at multiple point using only one measurement.
Evaluating the benefits of real-time feedback in mobile augmented reality with hand-held devices (2012)

Augmented Reality (AR) has been proved useful to guide operational tasks in professional domains by reducing the shift of attention between instructions and physical objects. Modern smartphones make it possible to use such techniques in everyday tasks, but raise new challenges for the usability of AR in this context: small screen, occlusion, operation "through a lens". We address these problems by adding real-time feedback to the AR overlay. We conducted a controlled experiment comparing AR with and without feedback, and with standard textual and graphical instructions. Results show significant benefits for mobile AR with feedback and reveals some problems with the other techniques.