gebhart/patrepeval huggingface dataset:
Development of Novel Rare-Earth Complexes and Their Application to Emission Devices (2008)

Colorless and transparent emission materials are being rapidly developed in view of their potential for use in emission devices, ornaments, and other applications. We focused on rare-earth complexes because of their transparency when dissolved in polymer and pure color emission. The first concept of novel molecular design of rare-earth complexes, namely, introduction of two different phosphine oxides into one rare-earth ion as ligands, was established, and their solubility and emission intensity were drastically enhanced. The second concept is that two different phosphine oxides are tied together and asymmetric bis-phosphine oxide structure is introduced to one rare-earth ion. The emission intensity of an Eu(III) complex was further enhanced. Colorless and transparent emission materials using novel rare-earth complexes have excellent transparency and strong pure color emission, and are promising candidates for a variety of application fields, including emission devices, where the see-through feature will be essential.
A method of calculating the cost of reducing the risk exposure of non-compliant process instances (2009)

A method is introduced to measure the risk of being non-compliant and the cost of reducing the risk by performing internal audits with the help of automated audit tools. Risk exposure of a business process is defined in terms of the prevalence of non-compliant process instances that are subject to penalty. The risk exposure can be reduced by detecting the non-compliant process instances in advance with the help of manual audits and automated auditing tools. The cost of this hybrid approach, however, should be kept less than the reduction amount of risk exposure.
Acoustic beamfolding: New potentials enabled by interfacing reconfigurable origami and acoustic structures (2016)

Acoustic transducer arrays yield large spatial and spectral change in energy transmission through strategic positioning of planar array elements. Yet, unless array elements are actively tuned through phase delay controls, the array performance characteristics remain fixed and suitable for limited purposes. Origami, the art of paper folding, is a means to introduce enormous topological change through simple, kinematic translation and rotation of connected, planar facets, which is one reason for its growing attention as a fluent vehicle to remarkably adapt system properties for multifunctional purposes. In this research, we integrate acoustic transducer array development and origami design principles to establish a new framework for adaptive acoustic energy shaping effected by simple geometric and kinematic folding relations. From a flat-folded strip to an unfolded plane, our theoretical and experimental results show that this transducer design concept leads to powerful means to tune the significance of radiated acoustic energy across orders of magnitude and to easily tailor the acoustic power transmission to the far field.
The In Vitro and In Vivo Activity of Ciprofloxacin (1986)

The antibacterial activity of ciprofloxacin (Bay o 9867) was compared with those of norfloxacin, nalidixic acid, trimethoprim-sulfamethoxazole, cefaclor, sisomicin and cefotaxime in in vitro and mouse protection studies. Approximately 300 clinical isolates of clinically important gram-positive and gram-negative species were used. The median MICs of ciprofloxacin against gram-positive and gram-negative bacteria ranged from ≤ 0.015–1 mg/l. Ciprofloxacin was 2–8 fold more active than norfloxacin and 100-fold more active than nalidixic acid. It also had a wider spectrum of activity against gram-positive organisms including even enterococci. No cross-resistance was observed between ciprofloxacin and ß-lactam antibiotics or aminoglycosides. Only acidic pH conditions decreased its activity. Ciprofloxacin showed rapid bactericidal action against organisms in both the logarithmic and stationary growth phases. In mouse protection studies (intraperitoneal infection) ciprofloxacin was significantly more effective than norfloxacin, ampicillin, trimethoprim-sulfamethoxazole, and also showed excellent activity against Pseudomonas infections.
Melamine And Derivatives Of Melamine (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleMelamine And Derivatives Of MelamineBernard Bann and Samuel A. MillerCite this: Chem. Rev. 1958, 58, 1, 131–172Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/cr50019a004https://doi.org/10.1021/cr50019a004research-articleACS PublicationsRequest reuse permissionsArticle Views3466Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Equivalent Circuit Model of Top-Emitting OLED for the Designing of OLED-on-Silicon Microdisplay (2011)

In the commonly-used EDA software, there is no equivalent circuit model of top-emitting OLED for SPICE, so it is difficult while the OLED pixel driving circuits are designed such as in microdisplay applications. To solve the problem, its SPICE model of top-emitting OLED was studied in this paper. Three models including the diode-connected NMOS model, the single-diode model, and the double-diode paralleled model are discussed and their simulation results from EDA software HSPICE are compared. Results show that the fitted errors obtained from the diode-connected NMOS model is the smallest, but its simulated errors are the largest. The fitted errors and the simulated errors obtained from the single-diode model are also large. However, small fitted errors and simulated errors got from double-diode paralleled model show that this model satisfies the application of the designing for OLED pixel driving circuits.
Nuclear Origins of Cell-to-Cell Variability (2010)

During the past decade, it has become increasingly evident that there is variation in the transcriptome of genetically identical cells, even when grown in homogenous environments. This cell-to-cell variability has been shown to have a central role in processes ranging from stem cell differentiation to chemotherapy resistance. Given that many genes display extensive heterogeneity in their messenger RNA (mRNA) abundance on a per cell basis, understanding the nuclear sources of this variability is important for our fundamental grasp of nuclear function and stands to have clinical manifestations. In this chapter, we assess the contribution of different transcription regimes, nuclear architecture dynamics, RNA polymerase elongation, and gene copy number to transcriptome heterogeneity. We also discuss techniques that can be used to quantify single-cell mRNA abundance and conclude by commenting on future research directions.
ChemInform Abstract: THALLIUM IN DER ORGANISCHEN SYNTH. 35. MITT. OX. VON CYCLOHEXANONEN ZU ADIPOINEN UNTER VERW. VON THALLIUM(III)‐NITRAT (1973)

Abstract Cyclohexanon (I) liefert mit Thallium(III)‐nitrat über das Epoxid (II) das Adipoin (III).
Methodologies for Integration of PHM Systems with Maintenance Data (2007)

The Automatic logistics program in the Air Force seeks to reduce development, production, and ownership costs for the next generation fighter aircraft by increasing system reliability while reducing maintenance requirements. A large number of technologies are becoming available within the Prognostics and Health Management (PHM) community that will lead to reduced cost and increased availability.1 2 The challenge is to develop advanced technology to integrate available PHM information from a variety of different sources into the maintenance and logistics infrastructure. PHM and maintenance/logistics systems must be thoroughly examined and tightly integrated in order to perform maintenance actions in the most efficient way to reduce ownership cost and increase availability. This paper presents multi-agent technology that integrates maintenance and PHM data to provide more effective maintenance identification and scheduling. The proposed methodologies will enable the maintenance and logistics infrastructure to fully benefit from newly developed PHM systems. Additionally, the PHM systems update themselves based on feedback obtained from the maintenance systems. The integration will utilize intelligent software agent technology in order to develop such solutions within open, highly dynamic, uncertain and complex environments with data distributed over a network. This provides benefits such as reusability, scalability, and continuous improvement with dynamically evolving ability.
Design of an industrial all-terrain robot platform lessons learned in the design of a robotic mine safety platform for South African gold mines (2012)

This paper describes the design methodology behind the design of an underground autonomous mine safety platform. The robot is intended for use as an underground safety platform in gold mines of South Africa, where right after a blast the hanging wall (roof) and poles need to be inspected and cleared before the crew can enter. The robot platform has to deal with rough terrain and the steep slope of the South African Gold seam. The paper is a short summary of the robot design and the systems that run it.
The allergenic potential of sesquiterpene lactones in phytomedicines from Arnica – an immunologic revision (2006)

Preparations of Arnica montana L. flowers have been used in traditional medicine since a long time to treat a variety of inflammatory diseases. The secondary metabolites that mediate the anti-inflammatory effects are sesquiterpene lactones (SLs) of the 10α-methylpseudoguaianolide type like helenalin and 11α,13-dihyrohelenalin, and their ester derivatives. Several studies have shown that SLs exert this effect in part by inhibiting activation of the transcription factor NF-κB. Despite the proven anti-inflammatory effects, Arnica preparations are often considered as strong contact sensitizers and inducers of allergic contact dermatitis. This bad reputation is based on results from a guinea pig model where different preparations from Arnica montana and their isolated SLs turned out to be strong inducers of skin erythema and on case reports in the literature. In contrast to these findings, we had no success in causing contact hypersensitivity (CHS) to the same SLs and preparations in a well accepted mouse model, on the contrary, we observed an anti-inflammatory effect of Arnica tinctures in an allergic ear swelling reaction caused by the strong contact sensitizer TNCB.
A Novel Catheter System for Totally Implantable Intravenous Drug Therapy: Assessment of Catheter Function and Patency with Trepostinil Therapy (2008)

The Model 10642 vascular catheter along with the SynchroMed II implantable drug delivery system showed promising performance in a chronic animal model.
Direct aminolysis of nonactivated and thermally unstable esters at high pressure (1989)

Abstract The preparation of the amides 3 from a wide variety of nonactivated esters 1 and secondary amines 2 has been achieved at 8 kbar and around 45°C; scope and limitations are discussed. The method was also successfully applied for the aminolysis of alkyl 2‐arylsulfinylacetates 7 that are relatively sensitive to heat.
The Arabidopsis Dwarf Mutant shi Exhibits Reduced Gibberellin Responses Conferred by Overexpression of a New Putative Zinc Finger Protein (1999)

shi (for short internodes), a semidominant dwarfing mutation of Arabidopsis caused by a transposon insertion, confers a phenotype typical of mutants defective in the biosynthesis of gibberellin (GA). However, the application of GA does not correct the dwarf phenotype of shi plants, suggesting that shi is defective in the perception of or in the response to GA. In agreement with this observation, the level of active GAs was elevated in shi plants, which is the result expected when feedback control of GA biosynthesis is reduced. Cloning of the SHI gene revealed that in shi, the transposon is inserted into the untranslated leader so that a cauliflower mosaic virus 35S promoter in the transposon reads out toward the SHI open reading frame. This result, together with mRNA analysis, suggests that the phenotype of the shi mutant is a result of overexpression of the SHI open reading frame. The predicted amino acid sequence of SHI has acidic and glutamine-rich stretches and shows sequence similarity over a putative zinc finger region to three presumptive Arabidopsis proteins. This suggests that SHI may act as a negative regulator of GA responses through transcriptional control.
Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma (2012)

Angiogenesis inhibitors have long been considered desirable anticancer agents. However, it was found that many tumors could develop resistance to antiangiogenesis inhibitors. Antiangiogenic therapy results in metabolic stress. Autophagy is an important survival mechanism in cancer cells under metabolic stress; however, it remains unknown if autophagy contributes to antiangiogenesis resistance. In this study, we reported that bevacizumab treatment reduced the development of new blood vessels and inhibited cell growth in xenografts of hepatocellular carcinoma (HCC) tumors. Bevacizumab treatment also upregulated expression of the autophagy-related genes (Beclin1 and LC3) and increased autophagosome formation. Our in vitro studies demonstrated that autophagy inhibition significantly increased apoptosis of HCC cells during nutrient starvation or hypoxia. In addition, the combined treatment of an autophagy inhibitor and bevacizumab markedly inhibited the tumor growth of HCC xenografts, led to enhanced apoptosis, and impaired the proliferation of tumor cells compared with treatment with either drug alone. Furthermore, autophagy inhibition led to enhanced reactive oxygen species (ROS) generation in HCC cells exposed to nutrient starvation or hypoxia in vitro and increased DNA oxidative damage in vivo. Antioxidants reduced nutrient starvation or the hypoxia-induced cell death of HCC cells after autophagy inhibition. Our results suggest that autophagy modulates ROS generation and contributes to cell survival under metabolic stress. Therefore, autophagy inhibition may be a novel way of increasing the efficicacy of antiangiogenic agents in the treatment of HCC.
Highly selective multi-target 3D-printed microfluidic-based breath analyzer (2016)

This paper presents a low-cost, portable, and highly selective 3D-printed gas sensor for detection of human breath biomarker gases. To show the diagnostic power of the developed miniaturized gas sensor, capable of differentiating (ppm level) small concentrations of different volatile organic compounds (VOCs), the binary and triple mixtures of biomarkers in breath are tested. The main advantage of the proposed device over previous microfluidic-based gas sensors is the enhanced selectivity of gas detection in complex mixtures (using a novel surface treatment and optimization of the microchannels geometry). Moreover, the sensor recovery time is reduced to 120 seconds, as opposed to over 15 minutes in previous studies (without the coating).
Expression of Prostate-Specific Membrane Antigen (PSMA) on Biopsies Is an Independent Risk Stratifier of Prostate Cancer Patients at Time of Initial Diagnosis (2018)

<b>Background:</b> Stratifying prostate cancer (PCa) patients into risk groups at time of initial diagnosis enabling a risk-adapted disease management is still a major clinical challenge. Existing studies evaluating the prognostic potential of PSMA (prostate-specific membrane antigen) for PCa were performed on radical prostatectomy specimens (RPE), i.e., decision making for disease management was already completed at time of sample analysis. Aim of our study was to assess the prognostic value of PSMA expression for PCa patients on biopsies at time of initial diagnosis. <b>Methods:</b> PSMA expression was assessed by immunohistochemistry on 294 prostate biopsies with corresponding RPE, 621 primary tumor foci from 242 RPE, 43 locally advanced or recurrent tumors, 34 lymph node metastases, 78 distant metastases and 52 benign prostatic samples. PSMA expression was correlated with clinico-pathologic features. Primary endpoint was recurrence free survival. Other clinicopathologic features included WHO/ISUP grade groups, PSA serum level, TNM-stage, and R-status. Chi-square test, ANOVA-analyses, Cox-regression, and log-rank tests were performed for statistical analyses. <b>Results:</b> High PSMA expression on both biopsy and RPE significantly associates with a higher risk of disease recurrence following curative surgery. The 5-year-recurrence free survival rates were 88.2, 74.2, 67.7 and 26.8% for patients exhibiting no, low, medium, or high PSMA expression on biopsy, respectively. High PSMA expression on biopsy was significant in multivariate analysis predicting a 4-fold increased risk of disease recurrence independently from established prognostic markers. PSMA significantly increases during PCa progression. <b>Conclusion:</b> PSMA is an independent prognostic marker on biopsies at time of initial diagnosis and can predict disease recurrence following curative therapy for PCa. Our study proposes the application of the routinely used IHC marker PSMA for outcome prediction and decision making in risk-adapted PCa management on biopsies at time of initial diagnosis.
A Multi-level Aggregated Network for Image Restoration (2019)

Recently, significant progress has been witnessed in image restoration benefited from the development of deep convolutional neural networks (CNN). However, we note that many state-of-the-art image restoration networks can be unfolded as a one-level architecture, which is constructed by stacking multiple convolution layers or blocks. As the depth of network grows, the information flow is weakened. And, existing skip connection has restricted ability to pass the previous state to the latter layers in the network. Based on above observations, we explore a multi-level aggregated network (MLAN) to fully exploit features of deeper layers. The proposed MLAN can extract more features by merging layers at different levels progressively, and can better aggregate the features by the augmented connection manner. Experimental results demonstrate a satisfactory performance of the proposed model on different image restoration tasks.
Quantification of Global Myoelectric Spatial Activations to Delineate Normal Hamstring Function at Progressive Running Speeds: A Technical Report (2022)

Schlink, BR, Nordin, AD, Diekfuss, JA, and Myer, GD. Quantification of global myoelectric spatial activations to delineate normal hamstring function at progressive running speeds: A technical report. J Strength Cond Res 36(3): 867-870, 2022-Hamstring function is critical to maintain sport performance, and strain injuries to the biceps femoris muscle commonly force an athlete to withdraw from their sport while the muscle heals. Current mechanistic understanding of underlying injury and return-to-play (RTP) guidelines has limited prognostic value because of limitations in technology and nonfunctional assessment strategies to guide clinical care. Integrated structural and functional determinants and dynamic assessment methods are needed to guide advanced rehabilitation strategies for safe and rapid return to sport. A potential solution for assessment of hamstring function is high-density electromyography (EMG), which can noninvasively measure spatial muscle activity in dynamic environments. In this study, we demonstrated the utility of high-density EMG by measuring spatial myoelectric activity from the biceps femoris from a group of recreational athletes running at a range of speeds. The level of significance set for this study was p < 0.05. During the late swing phase of running, we observed increased EMG amplitudes in the central and distal portions of the muscle. There were no changes in this pattern of EMG activation across speed, suggesting that running speed does not affect the general neuromuscular recruitment in the biceps femoris. Applying these methods to athletes with hamstring strains may lead to a more complete understanding of muscle function during rehabilitation and adjunctively support current methods to enhance RTP decision-making.
Syntheses and structures of anionic closo-rhodacarborane clusters that contain a formal rhodium(I) vertex (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses and structures of anionic closo-rhodacarborane clusters that contain a formal rhodium(I) vertexJohn A. Walker, Carolyn B. Knobler, and M. Frederick HawthorneCite this: J. Am. Chem. Soc. 1983, 105, 10, 3368–3369Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ja00348a086https://doi.org/10.1021/ja00348a086research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts