gebhart/patrepeval huggingface dataset:
Effect of tranilast ophthalmic solution on allergic conjunctivitis in guinea pigs. (1993)

The effect of the ophthalmic solution of tranilast, an anti-allergic agent, on allergic conjunctivitis was studied in passively sensitized guinea pigs. We determined the content of uranine dye and histamine in tears and histopathologically examined palpebral conjunctiva. After instillation of antigen into the conjunctival sac, inflammation of the palpebral conjunctiva, an increase in leaked dye and the release of histamine were found. In the histopathological study, tranilast (1.0%) suppressed the appearance of edema and infiltration of inflammatory cells. Tranilast suppressed the leakage of uranine in a dose-dependent manner. A 0.5% solution of diphenhydramine also showed the inhibitory effect on the leakage of uranine. The inhibitory effect of 0.5% tranilast on antigen-induced dye leakage and histamine release lasted for 6 hr. These results suggest that topically applied tranilast is effective for allergic conjunctivitis.
Determination of Activation Energies for Ion Fragmentation by Surface-Induced Dissociation (1997)

We describe here a new method for extracting the activation energy for the formation of any fragment or reactively scattered ion that forms from a parent ion−surface collision. Our model is developed from first principles for collision-induced dissociation in the gas phase and then modified for surface-induced dissociation (SID). This approach is conceptually similar to that used for threshold collision-induced dissociation measurements in that it assumes a similar functional form for the dissociation cross section, it takes into account the partitioning of energy between the projectile and the target, and it deconvolutes these over the kinetic energy distribution of the parent ion beam. The activation energy is extracted by an analysis of the energy-resolved mass spectra and the kinetic energy distribution spectra for the surface-scattered ions. We test our method by determining the activation energies for the formation of the SiMe2+, SiMe+, SiD+ and Si+ fragment ions from the d9-SiMe3+ parent ion scattered off a hexanethiolate self-assembled monolayer adsorbed on Au(111). The differences between the literature and SID activation energies are rationalized by consideration of the experimental uncertainty in the method.
Pipelines, Templates and Transformations: XML for Natural Language Generation (2001)

Lateral (parasagittal) fluid-percussion brain injury of mild (1.0-1.5 atm) and moderate (2.1-2.4 atm) severity induced expression of mRNAs for the immediate early genes (IEGs) c-fos, c-jun and junB. At 5 min following mild brain injury, c-fos and junB mRNA were co-induced in the cortex ipsilateral to the impact site. Expression remained elevated up to 2 h after injury and returned to control levels by 6 h. Levels of c-fos mRNA increased in the cells of the hippocampal dentate gyrus as early as 5 min after mild brain injury and additionally in the areas CA1-3 by 30 min. By 2 h, no hippocampal c-fos mRNA was detectable. Induction of junB mRNA in the hippocampus was delayed, occurring at 30 min after injury, and remained elevated up to 2 h post injury. Increased levels of junB mRNA were also observed in the striatum ipsilateral to the injury. Increased expression of c-jun mRNA was restricted to the ipsilateral dentate gyrus and was observed at 5 min after injury and remained elevated up to 6 h. Although the temporal pattern of induction of individual IEGs after brain injury of moderate severity was similar to that observed after mild severity, moderate injury induced IEG mRNA in both injured and contralateral hemispheres. These data suggest that traumatic brain injury invokes a complex acute regional and cellular response which may involve the activation of multiple signal transduction pathways.
Myogel, a Novel, Basement Membrane-Rich, Extracellular Matrix Derived from Skeletal Muscle, Is Highly Adipogenic in vivo and in vitro (2008)

We found Myogel induces adipocyte differentiation in vitroand shows strong adipogenic potential in vivo, inducing the growth of well-vascularised adipose tissue. Myogel offers an alternative for current support scaffolds in adipose tissue engineering, allowing the scaling up of animal models towards clinical adipose tissue engineering applications.
Personalization for SIP multimedia communications with presence (2005)

This paper presents a 3-layer service architecture for the session initiation protocol (SIP) that incorporates other protocols to provide multimedia and presence communications. Beyond SIP basic services, personalized services are also addressed. To enrich presence related services, presence information is extended from the well known "online" and "offline" indicators to a much broader meaning that includes "location", "linestatus", "role" and "availability". Based on this, the call processing language (CPL) is extended to describe presence related personalized services in both call-processing systems and presence systems using information such as a person's presence status, time, address, language, or any of their combinations.
Radiofrequency ablation for palliative treatment of osseous metastases results in rapid, significant, and durable improvements in pain relief and quality of life: Results from the OPuS One trial. (2021)

12086 Background: Patients with bone metastases may experience pain and decreased quality of life. Standard of care therapies such as radiation therapy could take weeks for pain relief and carry a risk of radiation induced fracture. Minimally invasive percutaneous radiofrequency ablation (RFA) have been shown in small observational studies to be an alternative treatment for bone metastases. We report the results of the OPuS One trial evaluating RFA for the palliative treatment of patients with painful bone metastases. Methods: OPuS One (NCT03249584) was a multicenter prospective trial. 218 subjects with painful bone metastases (≥ 4/10 worst pain scores, Brief Pain Inventory [BPI], at target treated site) were enrolled from 15 sites. RFA was performed under image guidance at one or two locations. Vertebral augmentation was followed based on physician’s discretion. Subjects’ pain (BPI) and quality of life (EQ-5D) scores were calculated in subjects at three days, one week, and one, three, six, and 12 months post RFA. Rate of complete (0 pain score at treated site with no concomitant analgesic increase) and partial responders (≥ 2 pain score reduction without analgesic increase or analgesic reduction of ≥ 25% from baseline) were calculated. Device-, procedure-, and/or therapy-related adverse events (AEs) were collected. Results: 206 subjects, 113 (55%) female and 93 (45%) males (mean age was 63.7 years) were treated with RFA. Most common primary cancers were breast (23%), lung (23%), and kidney (10%). 184 (89%) subjects were treated for metastatic lesions involving the thoracolumbar spine and 22 (11%) subjects were treated for iliac crest, periacetabulum, sacrum or mixed vertebral and pelvic location. 99% (262/264) of RFA procedures were technically successful and 97% were followed by vertebral augmentation. Subjects reported significant improvement in worst pain from baseline at 7.8 to 5.5, 4.7, 3.6, 3.2, 2.4, and 2.6 at three days, one week and one, three, six, and 12 months post RFA, respectively (p &lt; 0.0001 for all visits). Significant improvements were also seen in average pain (p &lt; 0.0001 for all visits), pain interference (p &lt; 0.0001 for all visits), and quality of life scores (p &lt; 0.0001 for all visits). Overall response rates were 53%, 58%, 61%, 63%, 70%, and 75% at three days, one week, one month, three months, six months, and twelve months post RFA, respectively. Six AEs were reported with three as serious: intra-abdominal fluid collection, pneumonia and respiratory failure. 82 deaths were reported during the study, none were related to the device, therapy, and/or procedure. No skeletal related events were reported. Conclusions: In a large prospective multicenter trial, OPuS One, RFA provided rapid, significant, and durable improvements in pain relief and quality of life up to 12 months. Clinical trial information: NCT03249584.
Low-Noise Parametric Amplifier (1960)

The theory of the parametric amplifier has been reformulated to permit the prediction of noise temperature and pump power in terms of the physical parameters of the nonlinear element and circuit. The results of this analysis are supported by careful experiments at S-band using a gold-bonded germanium semiconductor diode. They can be summarized as follows. 1) Performance of a parametric amplifier using semiconductor diodes with respect to noise temperature and pump power can be accurately predicted, once the diode and circuit parameters have been measured. 2) It is shown that the ultimate limitation on noise temperature depends simply on the product of the diode cutoff frequency and the normalized capacitance swing. 3) The derived figure of merit for the diode can serve as a basis for optimum design of the semiconductor parameters.
Automatic position detection method for mounting ic parts on high‐density printed circuit boards (1986)

Abstract In the automatic mounting system, which mounts electronic parts on a printed board, a problem is that the object printed circuit board is becoming of higher density and the parts have a fine lead structure. It is necessary that the positions of the part and the printed board should be detected with a high accuracy. It also became important to cope with the diversified parts with different shapes. This paper proposes a new practical method of automatic position detection to solve those problems. The proposed system is composed of the position detection process for the part and the position detection process for the printed board. In the process for position detection of parts, the positions of more than one lead are detected by the pattern matching, determining the similarity between partial images, and the position and the inclination of the part are calculated based on the result of matching. The viewing field is set so that only several leads are observed by the TV camera, and the object lens is moved to X and J directions so that the viewing field can be shifted to any desired position. In the position detection of the printed board, the positions of the two marks printed on the board are detected, and the position and the inclination of the printed board are calculated based on the mark positions. To evaluate the effectiveness of the proposed method, the position detection experiment was performed for the actual part and printed board, indicating that the position can be detected with a high accuracy.
Human Apolipoprotein B Transgenic Mice Generated with 207- and 145-Kilobase Pair Bacterial Artificial Chromosomes (1997)

We reported previously that approximately 80-kilobase pair (kb) P1 bacteriophage clones spanning either the human or mouse apoB gene (clones p158 and p649, respectively) confer apoB expression in the liver of transgenic mice, but not in the intestine. We hypothesized that the absence of intestinal expression was due to the fact that these clones lacked a distant DNA element controlling intestinal expression. To test this possibility, transgenic mice were generated with 145- and 207-kb bacterial artificial chromosomes (BACs) that contained the human apoB gene and more extensive 5'- and 3'-flanking sequences. RNase protection, in situ hybridization, immunohistochemical, and genetic complementation studies revealed that the BAC transgenic mice manifested appropriate apoB gene expression in both the intestine and the liver, indicating that both BACs contained the distant intestinal element. To determine whether the regulatory element was located 5' or 3' to the apoB gene, transgenic mice were generated by co-microinjecting embryos with p158 and either the 5'- or 3'-sequences from the 145-kb BAC. Analysis of these mice indicated that the apoB gene's intestinal element is located 5' to the structural gene. Cumulatively, the transgenic mouse studies suggest that the intestinal element is located between -33 and -70 kb 5' to the apoB gene.
Credit ratings and bond spreads of the GIIPS (2015)

We examine the relationship between credit ratings and bond yield spreads of peripheral countries in the euro area (Greece, Ireland, Italy, Portugal and Spain) for the period 1995–2014. Since 2012, bond spreads of those countries have come down very fast, whereas credit ratings have hardly changed. Our results suggest that credit rating agencies have become more cautious and have changed their approach to assess credit risk of sovereigns, and that the impact of sovereign credit risk ratings on sovereign bond spreads has changed.
In Situ Forming, Cytocompatible, and Self-Recoverable Tough Hydrogels Based on Dual Ionic and Click Cross-Linked Alginate (2018)

A dual cross-linking strategy was developed to answer the urgent need for fatigue-resistant, cytocompatible, and in situ forming tough hydrogels. Clickable, yet calcium-binding derivatives of alginate were synthesized by partial substitution of its carboxyl functionalities with furan, which could come into Diels-Alder click reaction with maleimide end groups of a four arm poly(ethylene glycol) cross-linker. Tuning the cooperative viscoelastic action of transient ionic and permanent click cross-links within the single network of alginate provided a soft tough hydrogel with a set of interesting features: (i) immediate self-recovery under cyclic loading, (ii) highly efficient and autonomous self-healing upon fracture, (iii) in situ forming ability for molding and minimally invasive injection, (iv) capability for viable cell encapsulation, and (v) reactivity for on-demand biomolecule conjugation. The facile strategy is applicable to a wide range of natural and synthetic polymers by introducing the calcium binding and click reacting functional groups and can broaden the use of tough hydrogels in load-bearing, cell-laden applications such as soft tissue engineering and bioactuators.
Incorporating Long-Term Climate Variability into a Short-Timescale Rainfall Model Using a Hidden State Markov Model (2002)

Inter-annual persistence, a characteristic feature of Australian hydroclimatological series, is often difficult for event-based rainfall models to reproduce. This persistence can lead to poor reproduction of variables important in design such as Intensity-Frequency-Duration (IFD) curves and drought risk. This paper outlines the conditioning of a short-timescale rainfall model DRIP on the output series of a two-state Hidden Markov Model (HSM). The HSM model assumes that the rainfall in a particular year is in either a wet state or a dry state, with different rainfall distributions depending on the state. The inclusion of HSM into DRIP has produced a model that has improved capability to adequately reproduce rainfall characteristics including persistence for a variety of sites throughout Australia for timescales ranging from six minutes up to a year.
Egr-1 Is Necessary for Fibroblast Growth Factor-2-induced Transcriptional Activation of the Glial Cell Line-derived Neurotrophic Factor in Murine Astrocytes (2009)

Glial cell line-derived neurotrophic factor (Gdnf) promotes neurite outgrowth and survival of neuronal cells, but its transcriptional regulation is poorly understood. Here, we sought to investigate the mechanism underlying fibroblast growth factor-2 (FGF2) induction of Gdnf expression in astrocytes. We found that FGF2 stimulation of rat astrocytes induced expression of Egr-1 at a high level. Sequence analysis of the rat Gdnf gene identified three overlapping Egr-1-binding sites between positions -185 and -163 of the rat Gdnf promoter. Transfection studies using a series of deleted Gdnf promoters revealed that these Egr-1-binding sites are required for maximal activation of the Gdnf promoter by FGF2. Chromatin immunoprecipitation analysis indicated that Egr-1 binds to the Gdnf promoter. Furthermore, the induction of Gdnf expression by FGF2 is strongly attenuated both in C6 glioma cells stably expressing Egr-1-specific small interfering RNA and in primary cultured astrocytes from the Egr-1 knock-out mouse. Additionally, we found that stimulation of the ERK and JNK pathways by FGF2 is functionally linked to Gdnf expression through the induction of Egr-1. These data demonstrate that FGF2-induced Gdnf expression is mediated by the induction of Egr-1 through activation of the ERK and JNK/Elk-1 signaling pathways.
Towards Automatic Consistency Checking between Web Application and its Mobile Application (2014)

With the increasing usage of mobile devices in daily life, a lot of websites delivered another mobile application version of application with the same services. If the mobile application is inconsistent with the web application, it may imply possible error or misleading information in the mobile application. This paper proposes an approach for automatic consistency checking between mobile application and its web application. Our approach starts from the generation of page and link information by crawling content from web application and simulating user actions in Android application. Page matching and consistency checking algorithms are proposed and used to find out inconsistency in page, element and link. The validation tool is used in 3 mobile application containing more than 300 pages. The result shows that our approach can find out inconsistency with acceptable precision and recall. Keywords-Consistency checking, Black-Box, Mobile Application
Zero-Field Splitting in Pseudotetrahedral Co(II) Complexes: a Magnetic, High-Frequency and -Field EPR, and Computational Study (2013)

Six pseudotetrahedral cobalt(II) complexes of the type [CoL2Cl2], with L = heterocyclic N-donor ligand, have been studied in parallel by magnetometry, and high-frequency and -field electron paramagnetic resonance (HFEPR). HFEPR powder spectra were recorded in a 50 GHz < ν < 700 GHz range in a 17 T superconducting and 25 T resistive magnet, which allowed constructing of resonance field vs frequency diagrams from which the fitting procedure yielded the S = 3/2 spin ground state Hamiltonian parameters. The sign of the axial anisotropy parameter D was determined unambiguously; the values range between -8 and +11 cm(-1) for the given series of complexes. These data agree well with magnetometric analysis. Finally, quantum chemical ab initio calculations were performed on the whole series of complexes to probe the relationship between the magnetic anisotropy, electronic, and geometric structure.
Interim Report: 100-NR-2 Apatite Treatability Test: Low Concentration Calcium Citrate-Phosphate Solution Injection for In Situ Strontium-90 Immobilization (2008)

Following an evaluation of potential Sr-90 treatment technologies and their applicability under 100-NR-2 hydrogeologic conditions, U.S. Department of Energy, Fluor Hanford, Inc., Pacific Northwest National Laboratory, and the Washington Department of Ecology agreed that the long-term strategy for groundwater remediation at 100-N Area will include apatite sequestration as the primary treatment, followed by a secondary treatment if necessary (most likely phytoremediation). Since then, the agencies have worked together to agree on which apatite sequestration technology has the greatest chance of reducing Sr-90 flux to the river at a reasonable cost. In July 2005, aqueous injection, (i.e., the introduction of apatite-forming chemicals into the subsurface) was endorsed as the interim remedy and selected for field testing. Studies are in progress to assess the efficacy of in situ apatite formation by aqueous solution injection to address both the vadose zone and the shallow aquifer along the 300 ft of shoreline where Sr-90 concentrations are highest. This report describes the field testing of the shallow aquifer treatment.
ChemInform Abstract: ASYMMETRIC α‐ACETOXYLATION OF CARBOXYLIC ESTERS (1985)

Abstract Unter dem Einfluß der chiralen Hilfssubstanzen (I)‐(III) gehen die mit diesen derivierten Ester (IV) bzw. deren Silylderivate (V) eine "n‐face"‐selektive α‐Acetoxylierung bei der sukzessiven Behandlung mit Pb(O‐Ac)4 und Et3N ‐ HF ein unter Bildung der α‐Acetoxyester (VI), aus denen durch Reduktion die Diole (VII) bzw. durch Verseifen die 16 Hydroxysäure (VIII) erhältlich sind.
Towards autonomous service composition in a grid environment (2004)

Web services are becoming important in applications from electronic commerce to application interoperation. While numerous efforts have focused on service composition, service selection among similar services from multiple providers has not been addressed. Such issue is more serious when services are embraced in Grid platforms, which are usually resource-conscious. Experimental results show that our considerations are valid and our preliminary solution works well in our Globus grid network.
Perfusion Imaging of the Liver: Current Challenges and Future Goals (2005)

Improved therapeutic options for hepatocellular carcinoma and metastatic disease place greater demands on diagnostic and surveillance tests for liver disease. Existing diagnostic imaging techniques provide limited evaluation of tissue characteristics beyond morphology; perfusion imaging of the liver has potential to improve this shortcoming. The ability to resolve hepatic arterial and portal venous components of blood flow on a global and regional basis constitutes the primary goal of liver perfusion imaging. Earlier detection of primary and metastatic hepatic malignancies and cirrhosis may be possible on the basis of relative increases in hepatic arterial blood flow associated with these diseases. To date, liver flow scintigraphy and flow quantification at Doppler ultrasonography have focused on characterization of global abnormalities. Computed tomography (CT) and magnetic resonance (MR) imaging can provide regional and global parameters, a critical goal for tumor surveillance. Several challenges remain: reduced radiation doses associated with CT perfusion imaging, improved spatial and temporal resolution at MR imaging, accurate quantification of tissue contrast material at MR imaging, and validation of parameters obtained from fitting enhancement curves to biokinetic models, applicable to all perfusion methods. Continued progress in this new field of liver imaging may have profound implications for large patient groups at risk for liver disease.
Characterization of Folded, Intermediate, and Unfolded States of Recombinant Human Interstitial Collagenase (1996)

Recombinant interstitial collagenase (rMMP-1) forms insoluble inclusion bodies when over-expressed in Escherichia coli. We surveyed conditions for renaturation of purified rMMP-1 in 6 M guandine hydrochloride (GdnHCl) and found that optimal folding occurred when the denatured protein was diluted at 4 degrees C in approximately 2 M guanidine HCl, 20% glycerol, 2.5 mM reduced and oxidized glutathione, and 5 mM CaCl2, followed by buffer exchange to remove denaturant and thiols. The circular dichroism spectrum and catalytic constants of the refolded enzyme were similar to those of native MMP-1. The propeptide, which comprises approximately 20% of the mass of proMMP-1, was not required for folding to a functional enzyme. Size exclusion chromatography and spectroscopic measurements at intermediate [GdnHCl] revealed two intermediate folding states. The first, observed at 1 M GdnHCl, had a slightly larger Stokes' radius than the folded protein. CD and fluorescence analysis showed that it contained ordered tryptophan residues with a higher quantum yield than the fully folded state. The second intermediate, which appeared between 2 and 4 M GdnHCl, exhibited properties consistent with the molten globule, including secondary structure, lack of ordered tryptophan, exposed hydrophobic binding sites, and a Stokes' radius between that of the folded and unfolded states.