gebhart/patrepeval huggingface dataset:
Interim clinical trial analysis of intraoperative mass spectrometry for breast cancer surgery (2021)

Optimal resection of breast tumors requires removing cancer with a rim of normal tissue while preserving uninvolved regions of the breast. Surgical and pathological techniques that permit rapid molecular characterization of tissue could facilitate such resections. Mass spectrometry (MS) is increasingly used in the research setting to detect and classify tumors and has the potential to detect cancer at surgical margins. Here, we describe the ex vivo intraoperative clinical application of MS using a liquid micro-junction surface sample probe (LMJ-SSP) to assess breast cancer margins. In a midpoint analysis of a registered clinical trial, surgical specimens from 21 women with treatment naïve invasive breast cancer were prospectively collected and analyzed at the time of surgery with subsequent histopathological determination. Normal and tumor breast specimens from the lumpectomy resected by the surgeon were smeared onto glass slides for rapid analysis. Lipidomic profiles were acquired from these specimens using LMJ-SSP MS in negative ionization mode within the operating suite and post-surgery analysis of the data revealed five candidate ions separating tumor from healthy tissue in this limited dataset. More data is required before considering the ions as candidate markers. Here, we present an application of ambient MS within the operating room to analyze breast cancer tissue and surgical margins. Lessons learned from these initial promising studies are being used to further evaluate the five candidate biomarkers and to further refine and optimize intraoperative MS as a tool for surgical guidance in breast cancer.
Knowledge engineering for clinical consultation programs: modeling the application area. (1989)

Developers of computer-based decision-support tools frequently adopt either pattern recognition or artificial intelligence techniques as the basis for their programs. Because these developers often choose to accentuate the differences between these alternative approaches, the more fundamental similarities are frequently overlooked. The principal challenge in the creation of any clinical consultation program - regardless of the methodology that is used - lies in creating a computational model of the application domain. The difficulty in generating such a model manifests itself in symptoms that workers in the expert systems community have labeled "the knowledge-acquisition bottleneck" and "the problem of brittleness". This paper explores these two symptoms and shows how the development of consultation programs based on pattern-recognition techniques is subject to analogous difficulties. The expert systems and pattern recognition communities must recognize that they face similar challenges, and must unite to develop methods that assist with the process of building of models of complex application tasks.
Removal of N-glycosylation sites of the yeast acid phosphatase severely affects protein folding (1991)

The influence of N glycosylation on the production of yeast acid phosphatase was studied. A set of synthetic hypoglycosylation mutants was generated by oligonucleotide-directed mutagenesis of the 12 putative sequons (Asn-X-Ser/Thr). Derepression of the hypoglycosylation mutants and analysis of their molecular sizes showed that all 12 sequons of the wild-type acid phosphatase are glycosylated. Activity measurements in combination with pulse-chase experiments revealed that the specific activity was not impaired by the introduced amino acid exchanges. However, absence of N glycosylation severely affected protein folding. Protein folding was found to be the rate-limiting factor in acid phosphatase secretion, and improper folding resulted in irreversible retention of malfolded acid phosphatase in the endoplasmic reticulum. With a decreasing number of attached glycan chains, less active acid phosphatase was secreted. Efficiency of correct folding was shown to be temperature dependent; i.e., lower temperatures could compensate for the reduction in attached oligosaccharides. In addition, protein folding and stability were shown to depend on both the number and the position of the attached oligosaccharides. N glycosylation was found to occur in a process independent of secondary structures, and thus our data support the model of a cotranslocational mechanism of glycosylation.
The Carrying Capacity of the Environment as it Relates to Reproductive Morality (1995)

What is the carrying capacity of our planet for mankind? Is it limited or unlimited? Is human intelligence responsible for a potential control? In other words, is the reproductive morality a bioethical norm for controlling the future survival of mankind? These are some of the questions debated in the present paper.
Apparatus for Continuously Monitoring Hydrogen Gas Dissolved in Transformer Oil (1981)

This report presents an apparatus for continuously monitoring of hydrogen gas dissolved in transformer oil, in which a polyimide membrane is used to separate the hydrogen from the oil. The hydrogen is allowed to permeate through the membrane and contact a gas sensor every 72 hours. The characteristics of the permeation of the hydrogen gas through the polyimide membrane and of the detection of the hydrogen gas by the gas sensor are described under various conditions. Problems encountered when the apparatus is installed on a tran are also studied and solved. As a result, this new apparatus was found useful in determining whether a transformer is operating normally or not.
An Epipolar Line from a Single Pixel (2018)

Computing the epipolar geometry from feature points between cameras with very different viewpoints is often error prone, as an object's appearance can vary greatly between images. For such cases, it has been shown that using motion extracted from video can achieve much better results than using a static image. This paper extends these earlier works based on the scene dynamics. In this paper we propose a new method to compute the epipolar geometry from a video stream, by exploiting the following observation: For a pixel p in Image A, all pixels corresponding to p in Image B are on the same epipolar line. Equivalently, the image of the line going through camera A's center and p is an epipolar line in B. Therefore, when cameras A and B are synchronized, the momentary images of two objects projecting to the same pixel, p, in camera A at times t1 and t2, lie on an epipolar line in camera B. Based on this observation we achieve fast and precise computation of epipolar lines. Calibrating cameras based on our method of finding epipolar lines is much faster and more robust than previous methods.
Early decrement of serum carbohydrate antigen 19‐9 predicts favorable outcome in advanced pancreatic cancer (2015)

Abstract Background and Aim The role of carbohydrate antigen 19‐9 (CA 19‐9) for predicting treatment outcome in pancreatic ductal adenocarcinoma (PDAC) remains to be elucidated. This study was aimed to determine the correlation between early decrement in CA 19‐9 concentration and prognosis of advanced PDAC after chemotherapy. Methods All patients confirmed with locally advanced or metastatic PDAC who received initial systemic chemotherapy for at least two cycles in our institution between January 2012 and December 2013 were included. Serum CA 19‐9 concentrations at baseline and 8 weeks after the initiation of chemotherapy were obtained. Correlation between CA 19‐9 decrement and survival outcomes (time to progression [TTP] and overall survival [OS]) were evaluated. Results A total of 183 patients with initially elevated CA 19‐9 were included. OS and TTP was significantly longer for patients whose serum CA 19‐9 concentration decreased more than 10% from baseline ( n = 103), than that for patients whose serum CA 19‐9 was not decreased ( n = 80) (423 vs 155 days, P &lt; 0.001 for OS and 222 vs 75 days, P &lt; 0.001 for TTP). In multivariate analysis, CA 19‐9 decrement more than 10% from baseline was still a significant factor for longer OS (hazard ratio for progression 0.275 [0.184–0.412], P &lt; 0.001) and TTP (0.322 [0.219–0.473], P &lt; 0.001) in both stage III and IV. Conclusions The early decrement of CA 19‐9 after the initiation of chemotherapy was an independent factor related with better survival outcomes in unresectable PDAC.
Ethylene Polymers,LDPE (2001)

Abstract Low density polyethylene (LDPE) was the first thermoplastic polyolefin used commercially. It was discovered serendipitously in 1933 and was quickly utilized for radar sheathing during the war. LDPE, along with high density polyethylene (HDPE) and linear low density polyethylene (LLDPE), offers an unparalleled combination of low cost, ease of fabrication into a variety of end uses, and balance of physical properties. Polyethylene has displaced paper, metal, wood, and other materials of construction. LDPE is unique in its polymerization process. Free‐radical‐initiated polymerization is used to make LDPE, as compared to transition‐metal catalysis for HDPE and LLDPE. The free‐radical process leads to the unique molecular structure of LDPE: the presence of long‐chain branching. The long‐chain branching imparts unusual rheological behavior in both shear and extension. LDPE is used in a variety of applications, such as film, coating, molding, and wire and cable insulation. One of the reasons for its wide range of utility is its thermal stability and low toxicity.
Unsupervised cross-lingual speaker adaptation for HMM-based speech synthesis (2010)

In the EMIME project, we are developing a mobile device that performs personalized speech-to-speech translation such that a user's spoken input in one language is used to produce spoken output in another language, while continuing to sound like the user's voice. We integrate two techniques, unsupervised adaptation for HMM-based TTS using a word-based large-vocabulary continuous speech recognizer and cross-lingual speaker adaptation for HMM-based TTS, into a single architecture. Thus, an unsupervised cross-lingual speaker adaptation system can be developed. Listening tests show very promising results, demonstrating that adapted voices sound similar to the target speaker and that differences between supervised and unsupervised cross-lingual speaker adaptation are small.
Automated Adsorption Workflow for Semiconductor Surfaces and the Application to Zinc Telluride (2021)

Surface adsorption is a crucial step in numerous processes, including heterogeneous catalysis, where the adsorption of key species is often used as a descriptor of efficiency. We present here an automated adsorption workflow for semiconductors which employs density functional theory calculations to generate adsorption data in a high-throughput manner. Starting from a bulk structure, the workflow performs an exhaustive surface search, followed by an adsorption structure construction step, which generates a minimal energy landscape to determine the optimal adsorbate-surface distance. An extensive set of energy-based, charge-based, geometric, and electronic descriptors tailored toward catalysis research are computed and saved to a personal user database. The application of the workflow to zinc telluride, a promising CO<sub>2</sub> reduction photocatalyst, is presented as a case study to illustrate the capabilities of this method and its potential as a material discovery tool.
SOA Fiber Ring Laser-Based Three-State Optical Memory (2008)

By exploiting three coupled semiconductor optical amplifier (SOA) fiber ring lasers, a compact, integratable, and polarization-independent three-state all-optical memory is demonstrated, with 40-dB extinction ratio for each state. Dynamic flip-flop operation between states is also demonstrated with switching pulse energy of 13.6 nJ. Due to the broad bandwidth of SOA gain spectrum, the wavelength range of set pulses is large. Finally, the transition behavior of state switching is investigated.
Metal and Ceramic Components made via CAM-LEM Technology (2018)

CAM-LEM (Computer-Aided Manufacturing ofLaminated Engineering Materials) is&#13;\nan SFF technology suitable for many engineering materials for which feedstock is available in&#13;\nsheet form; lamination and post-processing procedures are materials specific. Two methods for&#13;\nproducing sheetstock, tapecasting and compression molding , are discussed and contrasted.&#13;\nCeramic and metallic components that have been produced via CAM-LEM are described.
Event extraction for DNA methylation (2011)

Our results demonstrate that reliable extraction methods for DNA methylation events can be created through corpus annotation and straightforward retraining of a general event extraction system. The introduced resources are freely available for use in research from the GENIA project homepage http://www-tsujii.is.s.u-tokyo.ac.jp/GENIA.
The radio-opacity of surgical and radiological devices used in vivo: a test method for markers in surgical gauze (1987)

Most radio-opaque markers used in surgical gauze contain barium sulphate, and a minimum percentage content of this is required to ensure an acceptable level of radio-opacity. When this minimum percentage is specified by Standards authorities, a suitable test method must be available to determine compliance. A new radiographic test method is presented which can be used to determine the barium sulphate content or equivalence to within 2% of compliance requirements. The method consists of immersing the marker in a solution of barium sulphate which is then radiographed. Compliance can be evaluated by inspection of the radiograph. The method was found to be virtually independent of x-ray energy, film-screen combination and thickness or shape of the test object. The method is also an appropriate test for any other material or object, such as vascular catheters used in radiology or small toys which pose an ingestion hazard.
Integrate gas turbine cogeneration with fired heaters (1984)

Heat and power cogeneration is a potentially rewarding technique for achieving energy savings when applied to process industry systems. This paper presents an innovative solution which can improve the efficiency of large petrochemical plants and refineries.
pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity (2014)

The poor water solubility and bioactivity of lipophilic phytochemicals can be potentially improved by delivery systems. In this study, a low-cost, low-energy, and organic solvent-free encapsulation technology was studied by utilizing the pH-dependent solubility properties of curcumin and self-assembly properties of sodium caseinate (NaCas). Curcumin was deprotonated and dissolved, while NaCas was dissociated at pH 12 and 21 °C for 30 min. The subsequent neutralization enabled the encapsulation of curcumin in self-assembled casein nanoparticles. The degradation of curcumin under encapsulation conditions was negligible based on visible light and nuclear magnetic resonance spectroscopy. The dissociation of NaCas at pH 12 and reassociation after neutralization were confirmed using dynamic light scattering and analytical ultracentrifugation. The curcumin encapsulated in casein nanoparticles showed significantly improved anti-proliferation activity against human colorectal and pancreatic cancer cells. The studied encapsulation method is promising to utilize lipophilic compounds in food or pharmaceutical industries.
Unexpected systemic phenotypes result from focal combined deficiencies of forebrain insulin receptor/IGF-1 receptor signaling (2019)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
In vivo immunomodulatory effects of ixodid ticks on ovine circulating T‐ and B‐lymphocytes (2004)

Selected aspects of the ovine immune system were examined during the course of repeated infestations with the ixodid ticks, Haemaphysalis bispinosa and Hyalomma anatolicum anatolicum that naturally infest sheep, either individually or together. By the use of flow cytometry it was shown that total T-lymphocyte numbers were significantly reduced from the sixth through the ninth days of all infestations. Gamma/delta (gammadelta+) and CD8+ T-lymphocytes were significantly depleted during tick feeding in all infested groups. CD4+ T-lymphocyte levels were significantly increased during secondary H. bispinosa and mixed species infestations. Hyalomma anatolicum anatolicum caused a significant increase in circulating B-lymphocytes over several days in both initial and secondary infestations. All infested sheep had increased CD4/CD8 and decreased T/B lymphocyte ratios during exposure to both ticks. Bromodeoxyuridine (BrdU) ELISA was used to measure in vitro proliferation of peripheral blood mononuclear cells stimulated with the T-lymphocyte mitogen Concanavalin A (Con A) after their collection from infested sheep. Significant suppression of in vitro proliferation occurred during first and secondary infestations with H. bispinosa, H. a. anatolicum and with both tick species together, beginning on the sixth day of infestation in all cases. These important tick species of sheep significantly modulate the numbers of immune effector cells and proliferation of T-lymphocytes derived from infested animals.
Data from Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma (2023)

&lt;div&gt;Abstract&lt;p&gt;PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. In this study, we report that PARK2 is frequently deleted and underexpressed in human glioma, and low PARK2 expression is associated with poor survival. Restoration of PARK2 significantly inhibited glioma cell growth both &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;, whereas depletion of PARK2 promoted cell proliferation. PARK2 attenuated both Wnt- and EGF-stimulated pathways through downregulating the intracellular level of β-catenin and EGFR. Notably, PARK2 physically interacted with both β-catenin and EGFR. We further found that PARK2 promoted the ubiquitination of these two proteins in an E3 ligase activity-dependent manner. Finally, inspired by these newly identified tumor-suppressive functions of PARK2, we tested and proved that combination of small-molecule inhibitors targeting both Wnt–β-catenin and EGFR–AKT pathways synergistically impaired glioma cell viability. Together, our findings uncover novel cancer-associated functions of PARK2 and provide a potential therapeutic approach to treat glioma. &lt;i&gt;Cancer Res; 75(9); 1815–27. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Electrical stimulation of cerebellar fastigial nucleus protects rat brain, in vitro, from staurosporine‐induced apoptosis (2001)

Electrical stimulation of the cerebellar fastigial nucleus (FN) elicits a prolonged (∼10 days) and substantial (50–80%) protection against ischemic and excitotoxic injuries. The mechanism(s) of protection are unknown. We investigated whether FN stimulation directly protects brain cells against apoptotic cell death in an in vitro rat brain slice culture model. Rats were electrically stimulated in FN or, as control, the cerebellar dentate nucleus (DN). Coronal slices through the forebrain were explanted, exposed to staurosporine, harvested, and analyzed for caspase‐3 activity by a fluorescence assay. FN, but not DN, stimulation significantly reduced staurosporine‐induced caspase‐3 activity by 39 ± 7% at 3 h, 31 ± 3% at 6 h and 26 ± 4% at 10 h of incubation. Immunocytochemistry revealed FN‐specific reductions in activated caspase‐3 mainly in glial‐like cells throughout the forebrain. FN stimulation also results in a 56.5% reduction in cytochrome c release upon staurosporine incubation. We conclude that neuroprotection elicited from FN stimulation can directly modify the sensitivity of brain cells to apoptotic stimuli and thereby suppress staurosporine induced apoptosis in adult rat brain slices. This model indicates that neuroprotection can be studied in vitro and provides new insight into the potential role of glial cells in ischemic protection of neurons induced by FN stimulation.
Supplementary Figure Legends from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis (2023)

Supplementary Figure Legends from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis
Are we going backwards (2014)

In the lead up to Bluestocking Week 2014 we had confirmation that our theme 'Crossing the Line' was spot on. In an interview defending the Abbott Coalition Government's policy of cutting government funding of universities and passing the burden onto students with high fees and interest rates on HELP loans, the Minister for Education Christopher Pyne explained that women can stick with studying nursing and teaching where the fees won't be so high.
ELECTRONIC QUESTIONNAIRE SYSTEM FOR THE COLLECTION OF RESEARCH DATA WITHIN THE FRAMEWORK OF LMS (2012)

PĹedloĹženĂĄ staĹĽ pĹedstavuje postup nĂĄvrhu a tvorby elektronickĂŠho dotaznĂ­kovĂŠho systĂŠmu vyuĹžitelnĂŠho pro sbÄr vĂ˝zkumnĂ˝ch dat. Tato data mohou slouĹžit pro potĹeby statistickĂŠho zpracovĂĄnĂ­ pomocĂ­ vĂ˝poÄetnĂ­ techniky napĹĂ­klad pĹi pouĹžitĂ­ multidimensionĂĄlnĂ­ch statistickĂ˝ch metod shlukovĂŠ a faktorovĂŠ analĂ˝zy. PĹedstavenĂ˝ systĂŠm byl v praxi pouĹžit pĹi sbÄru vĂ˝zkumnĂ˝ch dat v rĂĄmci ĹeĹĄenĂ­ projektu GA ÄR Ä. P407/11/1306 - Evaluace vzdÄlĂĄvacĂ­ch materiĂĄlĹŻ urÄenĂ˝ch pro distanÄnĂ­ vzdÄlĂĄvĂĄnĂ­ a e-learning.
Characteristics of Methanol and Iso-Octane Under Flashing and Non-Flashing Conditions in ECN-G Spray (2022)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;This paper investigated the spray characteristics of methanol under the flash and non-flash boiling conditions defined by the Engine Combustion Network (ECN) Spray G. As a counterpart, the spray features of iso-octane were also simulated and compared to methanol. The Volume of Fluid (VOF) approach under the Eulerian scheme was employed to model the internal nozzle flow details, which information was used to initialize the spray parcels and taken as input for the Lagrangian simulations, namely, the one-way coupling method. Since the Eulerian high-fidelity simulations allow capturing the effects of the flow inside the non-symmetrical injector, the rate of injection (ROI) profile, discharge coefficient, and plume angle et al. are not required for the Lagrangian simulations. The simulation results show that the flash boiling led to longer penetrations and higher evaporation compared to the non-flash boiling condition for both fuels. Compared to isooctane, methanol demonstrated a better mixing process owing to its unique physical properties resulting in a lower ratio between ambient and saturation pressure (Pa/Ps). To calibrate the experimental data, parametric simulations were conducted, and the effects of the turbulence model and spray break-up constants were investigated. The predicted spray penetrations were more sensitive to the spray breakup constants than to the turbulence parameters. The simulations under flash boiling conditions showed to be less sensitive to spray breakup constant calibration and required lower values for these constants.&lt;/div&gt;&lt;/div&gt;
PASSAGE FROM NEW ZEALAND TO NEW HOLLAND (2014)

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Measurement of Cardiac Output by Pulse Dye Densitometry Using Indocyanine Green (1997)

Pulse dye densitometry could measure CO repeatedly in patients having major surgery with the same degree of accuracy as the thermodilution method; however, a considerable degree of error was observed in some patients.