gebhart/patrepeval huggingface dataset:
Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. (1996)

TAL1 is a basic helix-loop-helix (bHLH) protein involved in hematopoietic development. In T cell acute lymphoblastic leukemic cells, TAL1 is aberrantly overexpressed and is thought to contribute to oncogenesis. To identify proteins that interact with TAL1 in mediating leukemogenesis, we used TAL1 as a bait in a two-hybrid interaction screen, and isolated a cDNA clone that encodes a unique GTP binding protein, DRG. The interaction between DRG and TAL1 was confirmed both in vitro and in vivo. DRG was also shown to bind in vitro to two TAL1-related proteins, TAL2 and Lyl1. Mutational analyses showed that the HLH domain of TAL1 was necessary and sufficient for its interaction with the C-terminus of DRG. Furthermore, while DRG and E47 compete to interact with TAL1, TAL1 binds to DRG and E47 in a mutually exclusive manner. In rat embryonic fibroblast transformation assays, DRG stimulated the cotransforming activity of c-myc and ras. Based on these results, DRG appears to be a potential target for TAL-like oncoproteins.
Los Sistemas de Información como campo científico en la administración y dirección de empresas . (2006)

Los sistemas y tecnologias de la informacion son elementos conceptualmente complejos y de caracter interdisciplinario que siempre han generado interes para la ciencia administrativa y la practica empresarial, con mas importancia, si cabe, en los ultimos anos, como consecuencia de un entorno economico y social marcado por la tecnologia. En este sentido, son numerosas las reflexiones que se han realizado a lo largo del tiempo sobre los impactos que los sistemas y tecnologias de la informacion tienen en las organizaciones y los multiples marcos de analisis que deben ser utilizados para investigar dichos efectos. Todo esto ha dado lugar a un campo de estudio dentro de la administracion de empresas muy diverso y complejo en cuanto a tematicas, metodologias y enfoques. Ante esta situacion, el objetivo del presente articulo es analizar, organizar y reflexionar sobre las principales aportaciones que, hasta el momento, se han realizado en la literatura y definir lo que pueden ser las tendencias futuras, de forma que este trabajo pueda facilitar a otros investigadores la compleja labor que supone el analisis de los sistemas y tecnologias de la informacion dentro de la administracion de empresas.
A δ T-Cell Receptor Deleting Element Transgenic Reporter Construct Is Rearranged in αβ but not γδ T-Cell Lineages (1995)

T cells can be divided into two groups on the basis of the expression of either alpha beta or gamma delta T-cell receptors (TCRs). Because the TCR delta chain locus lies within the larger TCR alpha chain locus, control of the utilization of these two receptors is important in T-cell development, specifically for determination of T-cell type: rearrangement of the alpha locus results in deletion of the delta coding segments and commitment to the alpha beta lineage. In the developing thymus, a relative site-specific recombination occurs by which the TCR delta chain gene segments are deleted. This deletion removes all D delta, J delta, and C delta genes and occurs on both alleles. This delta deletional mechanism is evolutionarily conserved between mice and humans. Transgenic mice which contain the human delta deleting elements and as much internal TCR delta chain coding sequence as possible without allowing the formation of a complete delta chain gene were developed. Several transgenic lines showing recombinations between deleting elements within the transgene were developed. These lines demonstrate that utilization of the delta deleting elements occurs in alpha beta T cells of the spleen and thymus. These recombinations are rare in the gamma delta population, indicating that the machinery for utilization of delta deleting elements is functional in alpha beta T cells but absent in gamma delta T cells. Furthermore, a discrete population of early thymocytes containing delta deleting element recombinations but not V alpha-to-J alpha rearrangements has been identified. These data are consistent with a model in which delta deletion contributes to the implementation of a signal by which the TCR alpha chain locus is rearranged and expressed and thus becomes an alpha beta T cell.
Improved outcomes using unmanipulated haploidentical hematopoietic stem cells combined with third‐party umbilical cord blood transplantation for non‐malignant diseases in children: The experience of a single center (2021)

The results of unmanipulated haploid HSCs combined with tp-UCB in pediatric patients with life-threatening NMD were promising. However, further research is now needed to determine specific factors that might influence the engraftment of HSCs.
A Randomized, Blinded Study to Validate the Merz Hand Grading Scale for Use in Live Assessments (2015)

High-weighted Kappa values and agreements demonstrate that consistency at different time points can be achieved individually and by different raters for live assessments. The MHGS is a suitable instrument for live assessment in the clinical setting.
Recent Advances in Chemistry of Phosphorus Heterocyclic Compounds (1972)

[in Japanese]
Gender representation in authorship in later-phase systemic clinical trials in biliary tract cancer (BTC). (2021)

348 Background: The proportion of females in medicine is increasing (approx. 50% in medical school/workforce), but disparities in female authorship in oncology research publications exist; female corresponding authorship reportedly ranges from 7.2-39.1% in oncology clinical trials (Ludmir et al 2019). This study aimed to describe and assess factors associated with female first and senior authorship in later phase systemic clinical trials in BTC and to identify any changes over time. Methods: Embase/Medline were used to identify final primary trial publications in BTC (2000-2020) (excluding phase I (PI) (expected to move to later phase), mixed tumour site trials, reviews, editorials and trial-in-progress publications). Gender was determined by inspection of names, google search and author communication. Chi-square tests and log regression were used to assess factors associated with female first and senior authorship, including changes over time (STATA16). Results: Of 501 publications, 163 met inclusion criteria; 80% single-arm PII and 15% and 5% randomised PII and PIII respectively; 73% enrolled ≤50 patients. Tumour primary sites were all BTC: 86%, cholangiocarcinoma: 8%, gallbladder cancer: 6%; 80% involved chemotherapy, 13% targeted therapy and 5% localised/systemic combinations; 65% were in first-line (1L) advanced setting, 17% post 1L, 13% advanced non-specified and 5% neo-adjuvant/adjuvant. Forty-eight percent received industry funding and 65% met primary end-point. Sixty-four percent were published post ABC-02 (Valle et al 2010). Publication impact factor (IF) was ≤5 in 50% and &gt;20 in 12%. Median number of authors in all publications was 11. Geographic location of all first and senior authors were Asia (42%/42%), Europe (29%/29%), USA (24%/22%) and other (4%/6%), respectively. Median individual trial female author representation was 25%; there were no female authors in 12% of trials. Overall, female first and senior author representation was 21% and 11%, respectively. Median position of first female author was second. In publications with IF ≤20 and &gt;20, there were 22% and 16% female first and 13% and 0% female senior authors, respectively. The phase of trial, journal IF, industry funding, or whether met primary end-point did not impact female first or senior author representation (all P&gt;.05). There were more female senior authors associated with “other” geographic locations (40% in 10 trials) (P=.016) vs Asia (7%), Europe (8%) and USA (14%). There were no significant changes in female first or senior author representation over time (‘00-05: 21%/18%, ‘06-10: 27%/5%, ‘11-15: 15%/15%, ‘16-20: 22%/9%, P=.738, and P=.508 respectively). Conclusions: Female first and senior author representation in later phase systemic clinical trial publications in BTC is low and has not changed significantly over time. The underlying reasons for this imbalance need to be better understood and addressed.
Synthesis of new aldehyde derivatives from β-lapachone and nor-β-lapachone (2003)

Derivatives 6a and 6b, have been obtained in a chemoselective manner by a two step synthesis from -lapachone (3a) and nor--lapachone (3b), respectively, using CH 2 N 2 in ether, which provided the lapachone-epoxide derivatives, 5a and 5b, followed by treatment with BF 3 .Et 2 O/CH 2 Cl 2 . Basic work-up of the reaction mixture of 5a or 5b with BF 3 .Et 2 O/CH 2 Cl 2 led instead to isolation of the rearranged derivatives 7a and 7b, respectively. An ab initio theoretical study [B3LYP/6-311+G(d)] on 3a indicated that the carbon atom, C6, carries a higher positive charge than that at C5 and hence predicts a greater reactivity towards nucleophiles at C6. Another important factor controlling the chemoselectivity in the reaction of 3a with CH 2 N 2 is the steric hindrance of the CH 2 groups of the pyran ring.
Per-Priority Flow Control (PPFC) for Enhancing Metro Ethernet QoS (2010)

This paper presents a novel scheme called per-priority flow control (PPFC) as an extension to the IEEE802.3x standard using a simple and efficient node buffer management strategy, where a physical channel was divided into several virtual channel based on the bandwidth value (QoS parameter) embedded into the IPv6 flow label field of each flow. Moreover, it investigates performance of new proposed priority PAUSE, which includes two new flexible programmable fields (predetermined pause time and priority) in order to provide granular flow control. The proposed PPFC is fair in the sense that it distributes the resources among the flows based on their priorities during congestion. Moreover it reduces the amount of buffer overflow and packet loss and it would provide an efficient use of link bandwidth with high throughput. In addition, priority PAUSE enables optimal bandwidth management of virtual channel for different IPv6 traffic priorities and it enhances the QoS in Metro Ethernet.
Design and Implementation of a Geographic Search Engine (2005)

In this paper, we describe the design and initial implementation of a geographic search engine prototype for Germany, based on a large crawl of the de domain. Geographic search engines provide a flexible interface to the Web that allows users to constrain and order search results in an intuitive manner, by focusing a query on a particular geographic region. Geographic search technology has recently received significant commercial interest, but there has been only a limited amount of academic work in this direction so far. Our prototype performs massive extraction of geographic features from crawled data, which are then mapped to coordinates and aggregated across link and site structure. This allows us to assign to each web page a set of relevant locations, called the geographic footprint of the page. The resulting footprint data is then integrated into a highperformance query processor on a cluster-based architecture. We discuss the various techniques, both new and existing, that are used for recognizing, matching, mapping, and aggregating geographic features, and describe how to integrate geographic query processing into a standard search engine architecture and search interface.
Accurate Measurements with Image-Assisted Total Stations and Their Prerequisites (2016)

Video theodolites were used in the 1980s for highly accurate, automated measurements. However, they disappeared from the market and research on these instruments was done by only a few institutions using self-made prototypes. Because of the release of new-generation image-assisted total stations (IATS) by different manufacturers since 2004, these instruments have become relevant again for broader user groups. In this article, different error sources that occur when working with an IATS are assessed. The theoretical origins of these errors are discussed, their dependence on the measurement geometry is worked out, and strategies for avoidance and modeling are provided. In experimental geodetic network measurements, the impact of the different error sources on the results are evaluated. With standard deviations of a few 0.01 mm for the estimated three-dimensional (3D) coordinates, it is demonstrated that the telescope camera of a modern IATS can be used as a highly accurate measurement sensor.
OBJECT RECOGNITION USING A TREE-LIKE PROCEDURE GENERATED FROM 3-D MODEL (1988)

This paper presents a vision system which automatically generates an object recognition procedure from a 3-D model, and recognizes the object by executing this procedure. The change in object appearances due to the viewpoint is a main issue in 3-D model vision. In this system, the appearances of an object from various view points are described with visible 2-D figures, such as parallel lines and ellipses. These figures are projections of linear or circular visible elements in the model. Then, the appearance descriptions are compared. Similar figures are extracted and merged into a new description, which represents a common and general appearance of the old ones. This process is iterated and ends in a tree-like procedure. The system search the procedure tree and recognizes the object. At a visited node of the tree, figure is estimated by the recognition procedure and looked for in the image. If such figures are detected, a child of the current node is selected for the next visit. Detected figures are used for estimation at the next node. The number of object candidates increases as the number of detected figures increases, and propagated candidates construct a tree. The system searches the candidate tree in addition to the procedure tree. Experimental results show the efficiency of proposed system.
An Ant Colony Inspired Cache Allocation Mechanism for Heterogeneous Information Centric Network (2021)

The cache allocation of in-network caching is fundamental to the quality of service in heterogeneous information centric network (ICN). The aim of the cache allocation is to efficiently allocate appropriate cache capacity to each router for storing content, avoiding the long-distance transmission cost from clients to servers. Existing works focus on the analysis of network topology. However, this way is computation-expensive for such analysis, at the same time it cannot reach a completely optimal network, due to its used multiple conflicting performance metrics. In this paper, we propose an ant colony inspired cache allocation mechanism (ACCM) for heterogeneous ICN, which is able to deal with the cache budget constraint. Specifically, we first construct an evaluation model of network performance, in terms of hit ratio, energy consumption, time latency, and throughput. Then, based on the evaluation model, we devise an ant colony inspired cache allocation mechanism, where the ICN topology system is mapped into an ant colony system and the cache allocation process is simulated by the ant colony foraging behavior. Our theoretical analysis shows that the proposed mechanism can converge to the best solution. Finally, we conduct simulations on AttMpls and TW Telecom topologies with real datasets in YouTube. Simulation results show the effectiveness and efficiency of the proposed mechanism on the simulation instances in terms of hit ratio, energy consumption, time latency, and throughput.
A review on efficient routing techniques in wireless sensor networks (2015)

In the 21 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> century, smart environment wireless sensor networks have become an integral part of our lives. These wireless sensor networks contain large numbers of computing devices i.e. motes, but it has a very limited battery life-time and communication abilities (i.e. capacity, bandwidth etc.). So energy and routing are also major issues for wireless sensor networks. Most of the researchers use different techniques to increase the performance of wireless sensor networks in terms of network lifetime and using different routing protocols. We propose the multi-hop neighbor information technique by using shortcut tree routing protocol in wireless sensor networks. This review paper describes the multi-hop neighbor information technique and routing protocol methodologies which enhance the performance of WSN's.
Controlling Spending For Health Care And Long-Term Care: Japan’s Experience With A Rapidly Aging Society (2023)

As the Japanese population has aged rapidly, Japan's experience has implications for other high-income countries, including the United States. The aging of Japan's population, coupled with the government's decision to implement a public long-term care insurance program in 2000, has increased the nation's expenditures. In acute care, costs have been relatively contained by biennially revising the fee schedule for all physician and hospital services and by lowering pharmaceutical prices. The fee schedule not only sets prices but also controls volume by setting the conditions of billing for each item. This fee schedule is applied to all social health insurance plans (which enroll all permanent residents of Japan) and to virtually all providers. In contrast, despite the use of a similar fee schedule, spending in long-term care insurance has increased more than spending in health care. This is both because long-term care became an entitlement and because aging has had a greater impact on long-term care insurance spending than on health insurance spending. In this article we analyze Japanese expenditure data to provide essential information to the US as the percentage of its population ages sixty-five and older continues to rise. A key lesson that the US can learn from Japan's experience is that as its population ages, the need for long-term care will increase, necessitating better control of acute care spending.
Arthroscopy Techniques Achieves PubMed Central Citation, Yet Knee and Shoulder Outcome Failures Represent a Challenge, and a Presidential Address Prepares Us for Adversity (2013)

At the April 2013 Arthroscopy Association of North America annual meeting in San Antonio, Nick Sgaglione shared “a story about getting knocked down and getting back up.” If you missed Nick's inspirational presidential address at the AANA meeting, and if you missed reading it in last month's issue, be sure go back and find Past President Sgaglione's speech, or check it out at www.arthroscopyjournal.org. “Leadership in the Face of the Adversity” includes a message that can benefit each and every one of us.
Oral gentamicin therapy for Carbapenem-resistant Klebsiella pneumoniae gut colonization in hematologic patients: a single center experience. (2017)

The mortality for carbapenem-resistant Klebsiella pneumoniae (KPC-Kp) infection ranges from 18 to 48% depending on the type of therapy. Mortality rates in hematologic patients are even higher, up to 85%. Gut decontamination with oral gentamicin might be an option to avoid a subsequent KPC-Kp infection in colonized patients. We treated 14 hematologic patients with oral gentamicin, 80 mg four times daily, for 7 to 25 days in order to eradicate KPC-Kp from the gut, starting oral gentamicin therapy when possible after the discontinuation of systemic antibiotic therapy. The overall decontamination rate in the entire study population was 71% (10/14). Out of the 4 patients who did not respond to oral gentamicin therapy, 1 KPC-Kp strain was gentamicin resistant and 4 patients received concomitant systemic antibiotic therapy (CSAT). One of these patients died from KPC-Kp sepsis. The decontamination rate was 90% (9/10) in patients receiving oral gentamicin only, versus 25% (1/4) in those also treated with CSAT. No new gentamicin-resistant KPC-Kp strain was isolated during oral gentamicin therapy Oral gentamicin might be useful for gut decontamination and prevention of KPC-Kp infection. This option should be considered in patients colonized by a gentamicin-susceptible KPC-Kp strain and not receiving CSAT.
Testable Design for Advanced Serial-Link Transceivers (2007)

This paper describes a DfT solution for modern serial-link transceivers. We first summarize the architectures of the crosstalk canceller and the equalizer used in advanced transceivers to which the proposed solution can be applied. The solution addresses the testability and observability issues of the transceiver for both characterization and production testing. Without using sophisticated testing instrument setting, the proposed solution could test the clock and data recovery circuit and characterize the decision-feedback equalizer in the receiver. Our experiments demonstrate that the proposed method has significant higher fault coverage and lower hardware requirement than the conventional approach of probing the eye-opening of the signals inside the transceiver
Influence of Basic Red 1 dye adsorption on thermal stability of Na-clinoptilolite and Na-bentonite (2010)

Influence of physically adsorbed basic red 1 (BR1) dye on the physicochemical properties of natural zeolite (clinoptilolite) and clay (bentonite) was compared using adsorption, FTIR, and TG/DTA methods. A larger adsorption of the dye was observed for bentonite (0.143 mmol/g) than for clinoptilolite (0.0614 mmol/g) per gram of an adsorbent. However, the adsorption values are the same per surface unit (1.8 μmol/m2). The result (per gram) is due to location of dye molecules in interlayer and interparticle space of bentonite with much larger specific surface area than that of clinoptilolite. The dye adsorption leads to a decrease in the specific surface area and the pore volume of both minerals. The adsorption changes also a character of active sites and thermal stability. A TG study shows that the dye adsorption on bentonite changes adsorbed water amounts, weight loss, and decomposition temperature. In the case of zeolite, the dye adsorption insignificantly influences the thermal stability. The dehydration energy distributions calculated from the Q-TG and Q-DTG data demonstrate a complex mechanism of water thermodesorption and the influence of adsorbed dye on this process.
AGRONOMY AND SOILS Effect of Carrier Volume and Nozzle Type on Cotton Harvest-aid Efficacy (2006)

Chemical defoliation of cotton (Gossypium hirsutum L.) in preparation for mechanical harvest can be difficult because of inconsistent response of plants to harvest-aid applications. Unsatisfactory harvest-aid performance is often blamed on envi-ronmental conditions, but proper selection of car-rier volume and nozzle type may help to improve harvest-aid efficacy. The objective of this study was to determine the optimum combination of carrier volume and nozzle type for maximizing harvest-aid efficacy. Desiccation, defoliation, and regrowth were evaluated on cotton treated with tribufos or thidiazuron alone at carrier volumes of 47, 94, and 140 L ha-1 with flat fan, hollow cone, or air induc-
ANTI-IL-2 Receptor Antibody Treatment for Lymphoproliferative Disease: Transient Response in A Case of Ki-1+ Anaplastic Large Cell Lymphoma (1991)

Most cases of Ki-1 + anaplastic large cell lymphomas (ALCL) express the CD25 antigen, and we have recently shown that IL-2 producing cells can also be detected in these lymphomas. The latter cells may thus constitute targets for anti-CD25 Mab treatment. In one patient with a chemoresistant disseminated Ki-1 + ALCL such a therapeutic approach was undertaken. We report the dramatic antitumoral effect of anti-CD25 Mab obtained in this patient. This confirms the observation, previously reported in adult T cell leukemia, showing that this therapeutic regimen is also efficient in CD25 + solid tumors.