gebhart/patrepeval huggingface dataset:
Aerobic exercise before diving reduces venous gas bubble formation in humans (2004)

We have previously shown in a rat model that a single bout of high-intensity aerobic exercise 20 h before a simulated dive reduces bubble formation and after the dive protects from lethal decompression sickness. The present study investigated the importance of these findings in man. Twelve healthy male divers were compressed in a hyperbaric chamber to 280 kPa at a rate of 100 kPa min(-1) breathing air and remaining at pressure for 80 min. The ascent rate was 9 m min(-1) with a 7 min stop at 130 kPa. Each diver underwent two randomly assigned simulated dives, with or without preceding exercise. A single interval exercise performed 24h before the dive consisted of treadmill running at 90% of maximum heart rate for 3 min, followed by exercise at 50% of maximum heart rate for 2 min; this was repeated eight times for a total exercise period of 40 min. Venous gas bubbles were monitored with an ultrasonic scanner every 20 min for 80 min after reaching surface pressure. The study demonstrated that a single bout of strenuous exercise 24h before a dive to 18 m of seawater significantly reduced the average number of bubbles in the pulmonary artery from 0.98 to 0.22 bubbles cm(-2)(P= 0.006) compared to dives without preceding exercise. The maximum bubble grade was decreased from 3 to 1.5 (P= 0.002) by pre-dive exercise, thereby increasing safety. This is the first report to indicate that pre-dive exercise may form the basis for a new way of preventing serious decompression sickness.
Compelling Heat Transfer Augmentation of Laminar Natural Convection from Vertical Plates to Binary Gas Mixtures Formed with Light Helium and Selected Heavier Gases (2023)

The present study addresses a remarkable behavior of certain binary gas mixtures in connection to laminar natural convection along a heated vertical plate at constant temperature. The binary gas mixtures are formed with light helium (He) as the primary gas and selected heavier secondary gases. The heavier secondary gases are nitrogen (N2), oxygen (O2), xenon (Xe), carbon dioxide (CO2), methane (CH4), tetrafluoromethane (CF4) and sulfur hexafluoride (SF6). The central objective in the study is to investigate the attributes of the set of seven He‒based binary gas mixtures for heat transfer enhancement with respect to the heat transfer with helium (He) and air. From heat convection theory, four thermo‒physical properties: viscosity η, density ρ, thermal conductivity λ, and isobaric heat capacity Cp affect the thermo‒buoyant convection of fluids. In this study it became necessary to construct a particular correlation equation consigned to the set of seven He‒based binary gas mixtures, which operate in the Prandtl number closed sub‒interval [0.1, 1]. The heat transfer rate with the set of seven He‒based binary gas mixtures from the vertical plate involves four thermo‒physical properties: density ρmix, viscosity ηmix, thermal conductivity λmix, and isobaric heat capacity Cp, mix that vary with the molar gas composition w. A case study is performed to elucidate the unique characteristics of the modified convective heat transport that the set of seven He‒based binary gas mixtures brings forward as compared to the convective heat transport of He and air. It was found that the He+SF6 binary gas mixture renders an absolute maximum heat transfer enhancement rate that is 39 times higher than the heat transfer rate provided by He and 78 times higher than air.
Prediction of IC50Values for ACAT Inhibitors from Molecular Structure (2000)

A quantitative structure-activity study is performed on several series of compounds derived from N-chlorosulfonyl isocyanate to develop models that relate their structures to IC50 activity for inhibition of acyl-CoA:cholesterol O-acyltransferase (ACAT). Numerical descriptors are used to encode topological, electronic, and geometric information from the molecular structures of the inhibitors. A data set of 157 compounds showing triglyceride- and cholesterol-lowering activity is used to develop successful linear regression models and nonlinear computational neural network models. The models are validated using an external prediction set.
Using an Internal State Variable Model Framework to Investigate the Influence of Microstructure and Mechanical Properties on Ballistic Performance of Steel Alloys (2023)

An internal state variable (ISV)-based constitutive model has been used within a Lagrangian finite element analysis (FEA) framework to simulate ballistic impact of monolithic rolled homogenous armor (RHA) steel plates by RHA steel spheres and cylinders. The ISV model predictions demonstrate good agreement with experimental impact data for spherical projectiles. A simulation-based parametric sensitivity study was performed to determine the influence of a variety of microstructural and mechanical properties on ballistic performance. The sensitivity analysis shows that the lattice hydrogen concentration, material hardness, and initial void volume fraction are dominant factors influencing ballistic performance. Finite element simulations show that variation of microstructure properties could explain the reduced ballistic performance of high hardness materials previously documented in the literature. The FEA framework presented in this work can be used to determine material properties conducive to ballistic-impact resistance.
On the Occurrence of Electron Transfer in Aliphatic Nucleophilic Substitution. (1991)

Three types of evidence, the activation entropy and enthalpy based on temperature measurements, stereochemical results based on preparative electrolysis, and k SUB /k ET values based on kinetic measurements give the picture that sterically very hindered alkyl halides react with aromatic anion radicals and certain anions in an outer-sphere electron transfer, whereas a certain stabilization of the transition state is found when the steric hindrance is diminished. The activation entropies and activation enthalpies for the reactions between aromatic anion radicals or the anion of 1,4-dihydro-4-methoxycarbonyl-1-methylpyridine and alkyl halides have been calculated from the temperature dependence of the rate constants
S1606 A Retrospective Study of Doxycycline-Based Quadruple Therapy versus Tetracycline-Based Quadruple Therapy for the First Line Treatment of Helicobacter pylori (2022)

Introduction: The global prevalence of antimicrobial resistance has resulted in challenges with H. pylori eradication. Gastric acid suppression and antibiotic therapy are used to eradicate H. pylori. Cost and shortages inhibit use of tetracycline for first line treatment of H. pylori. Doxycycline represents a possible cost-effective alternative for treating H. pylori. We performed an analysis of first line doxycycline-based quadruple therapy in comparison to tetracycline-based quadruple therapy in the eradication of H. pylori. Methods: A retrospective chart review was conducted using the Advocate Aurora Health database, a multi-hospital community-based system consisting of sixteen hospitals and over 500 sites of care. All patients age 18 and older with documented H. pylori infection treated with either a first line doxycycline-based regimen (DOX) or tetracycline-based regimen (TCN) from January 2012 to April 2022 were included. In total, 3,384 patients were identified. Patients who received prior first-line treatment with other regimens were excluded. All cases were reviewed for confirmation of infection (either by biopsy, breath test or stool antigen testing), the treatment regimen used, and confirmation of H. Pylori eradication (either by biopsy, breath test, or stool antigen). Patients without confirmation of eradication or with pending eradication test results were excluded. Patient demographics were summarized and eradication rates determined. Results: Of the 3,384 reviewed cases, 628 cases met inclusion and exclusion criteria. Of these, 305 patients were treated with DOX and 323 patients were treated with TCN. Based on these numbers, a posteriori non-inferiority calculation with an assumed 85% eradication rate for the TCN and 80% for DOX and 90% power suggested 100 patents were needed per group (HyLown Consulting LLC, Statistical Calculators). The average age for DOX was 57 years and 193/305 (60%) were female. The average age for TCN was 58.5 years and 210/323 (69%) were female. Eradication rates were 87.6% for DOX and 88.2% for TCN (Table). Conclusion: Doxycycline-based quadruple therapy regimen is effective and appears to be non-inferior to tetracycline-based quadruple therapy regimens for first line treatment of H. pylori. Table 1. - The number of patients with tetracycline or doxycycline antibiotic regimens and the eradication rate Doxycycline Regimen # of Patients % of Patients Successful Eradication 283 87.6% Failed Eradication 40 12.4% Total 323 Tetracycline Regimen # of Patients % of Patients Successful Eradication 269 88.2% Failed Eradication 36 11.8% Total 305
Incorporation of multiple reporter groups on synthetic oligonucleotides (1990)

Journal Article Incorporation of multiple reporter groups on synthetic oligonucleotides Get access Jin Yan Tang, Jin Yan Tang Worcester Foundation for Experimental Biology222 Maple Avenue, Shrewsbury, MA 01545, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Sudhir Agrawal Sudhir Agrawal * Worcester Foundation for Experimental Biology222 Maple Avenue, Shrewsbury, MA 01545, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 21, 21 November 1990, Page 6461, https://doi.org/10.1093/nar/18.21.6461 Published: 21 November 1990 Article history Received: 19 September 1990 Published: 21 November 1990
Methods to use 6LoWPAN in IPv4 network (2007)

6LoWPAN is low power wireless personal area network based on IPv6 and IEEE802.15.4. It is used for transmission of IPv6 packets. But there are no ways for IPv4 hosts to connect 6LoWPAN, current Internet users can't use 6LoWPAN until IPv6 is deployed. In this paper, we propose the methods to use 6LoWPAN in IPv4 network so that IPv4 user can also utilize 6LoWPAN techniques.
ANALISIS OLAHRAGA PRESTASI YANG DAPAT DI UNGGULKAN KABUPATEN LANGKAT (2019)

Penelitian ini bertujuan untuk mengetahui cabang olahraga unggulan yang ada di Kabupaten Langkat. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan menggunakan angket, jumlah populasi  dalam penelitian ini adalah 28 cabang olahraga dan sempel penelitian adalah 21 cabang olahraga, kemudian dilakukan penyebaran angket dilokasi penelitian. Dari hasil penyebaran angket, melakukan wawancara kepada salah satu pengurus cabang olahraga sepak bola, dan setelah dianalisis olahraga prestasi yang di unggulkan melihat dari 10 variabel yaitu atlet, pembinaan usia dini, sekolah, latihan, kompetisi, pelatih, IPTEK keolahragaan, dana, jaminan masa depan, organisasi profesional, dengan demikian olahraga prestasi yang dapat diunggulkan di Kabupaten Langkat adalah sepak bola dan pencak silat. Kata Kunci: Olahraga Prestasi, Unggul
Successful and safe response to ibrutinib alone in treating relapsed Waldenström macrogobulinemia and related acquired von Willebrand syndrome: an option to consider (2022)

Ibrutinib, a first-class Bruton tyrosine kinase inhibitor, is known to be associated with adverse bleeding events and has been recently approved for the treatment of relapse Waldenström macroglobulinemia (WM). Here, we report the exhaustive clinical and biological follow-up of 2 patients treated by ibrutinib alone in the context of relapsed WM with an acquired von Willebrand syndrome (AVWS) complication. In two cases, ibrutinib has been shown to be quickly efficient and safe for treating both AVWS and its underlying condition the WM, without bleeding complications. Interestingly, ibrutinib treatment brings a rapid and extended over time normalization of von Willebrand factor clearance. These observations show that ibrutinib is a valuable therapeutic option in relapsed WM patients associated with AVWS and highlighting the need for further cohort studies with long-term follow-up of patients to confirm the efficacy and safety of a treatment by ibrutinib for WM patients with AVWS complication.
Reactions of a Triruthenium Pentahydrido Complex with Imines Leading to the Formation of a Perpendicularly Coordinated Iminoacyl Ligand and the Scission of a C═N Bond on a Triruthenium Plane (2012)

The reaction of a triruthenium pentahydrido complex, {Cp*Ru(μ-H)}3(μ3-H)2 (1; Cp* = η5-C5Me5), with N-benzylidenemethylamine resulted in the exclusive formation of a perpendicularly coordinated iminoacyl complex, (Cp*Ru)3(μ-η2:η2(⊥)-PhCNMe)(μ-H)2 (3b), as a result of C–H bond scission of imine. However, the treatment of 1 with N-benzylideneaniline at 100 °C caused C–N bond cleavage to yield the μ3-benzylidyne−μ3-phenylimido complex (Cp*Ru)3(μ3-CPh)(μ3-NPh)(μ-H)2 (7c) and the μ3-methylidyne−μ3-phenylimido complex (Cp*Ru)3(μ3-CH)(μ3-NPh)(μ-H)2 (8). The formation of 7c is in strong contrast to the C–N bond scission occurred in (Cp*Ru)3(μ-η2:η2(⊥)-PhCNH)(μ-H)2 (3a), which required heating at 180 °C. The structural and spectral properties of μ3-η2:η2(⊥)-nitrile complex 2, cationic μ3-η2:η2(⊥)-iminoacyl complex 6, and neutral μ3-η2:η2(⊥)-iminoacyl complex 3 revealed a clear trend of the activation of the C–N bond on a Ru3 plane. The thermolysis of 3b proceeded in a different manner to yield a μ3-methylidyne−μ3-η2(∥)-iminoacyl complex, (Cp*Ru)3(μ3-CH)(μ3-HNCH)(μ-H) (9), as a consequence of both C–N and C–C bond scission.
Mesoporous nitrogen-rich carbons derived from protein for ultra-high capacity battery anodes and supercapacitors (2013)

In this work we demonstrate that biomass-derived proteins serve as an ideal precursor for synthesizing carbon materials for energy applications. The unique composition and structure of the carbons resulted in very promising electrochemical energy storage performance. We obtained a reversible lithium storage capacity of 1780 mA h g−1, which is among the highest ever reported for any carbon-based electrode. Tested as a supercapacitor, the carbons exhibited a capacitance of 390 F g−1, with an excellent cycle life (7% loss after 10 000 cycles). Such exquisite properties may be attributed to a unique combination of a high specific surface area, partial graphitization and very high bulk nitrogen content. It is a major challenge to derive carbons possessing all three attributes. By templating the structure of mesoporous cellular foam with egg white-derived proteins, we were able to obtain hierarchically mesoporous (pores centered at ∼4 nm and at 20–30 nm) partially graphitized carbons with a surface area of 805.7 m2 g−1 and a bulk N-content of 10.1 wt%. When the best performing sample was heated in Ar to eliminate most of the nitrogen, the Li storage capacity and the specific capacitance dropped to 716 mA h g−1 and 80 F g−1, respectively.
Escherichia coli BdcA controls biofilm dispersal in Pseudomonas aeruginosa and Rhizobium meliloti (2011)

Since BdcA shows the ability to control biofilm dispersal in diverse bacteria, BdcA has the potential to be used as a tool to disperse biofilms for engineering and medical applications.
New G protein coupled receptor targets for 3-iodotyronamine (2015)

So far most in vivo effects of 3-iodothyronamine (3-T1AM) are thought to be mediated by binding at the trace amine-associated receptor 1 (TAAR1). Inconsistently, 3-T1AM effects still persist in Taar1 knockout mice, suggesting additional receptor targets. It has previously been reported that 3-T1AM also binds to the alpha-2A-adrenergic receptor (ADRA2A) modulating insulin secretion. We speculated that this effect is mediated by interaction with ADRA2A or with a ADRA2A/TAAR1 complex. To unravel the signaling properties of ADRA2A in interplay with 3-T1AM we first investigated on a potential general signaling modification by the label-free EPIC-technology and then specified changes in signaling by cAMP inhibition and MAPK (ERK1/2) assays. We found that 3-T1AM induces Gi/o activation at ADRA2A. In contrast to nor-epinephrine (NorEpi), 3-T1AM did not activate the MAPK pathway but reduced the NorEpi-induced MAPK activation. Interestingly, co-expression of TAAR1 and ADRA2A as it occurs e.g. in pancreatic β-cells, abolished NorEpi-induced Gi/o signaling at ADRA2A. In addition, in ADRA2A/TAAR1 hetero-oligomers application of NorEpi results in uncoupling of Gi/o signaling pathway, not affecting MAPK activation. RNA sequencing analyses showed significant co-expression of ADRA2A and TAAR1 in mouse pancreatic islets but chronical 3-T1AM application in mice over a period of six days had no significant effects on glucose homeostasis. Our study provides important insights into the 3-T1AM-mediated signaling spectrum. It revealed a direct influence of 3-T1AM on ADRA2A function activating Gi/o pathway and 3-T1AM-induced uncoupling of NorEpi-mediated ADRA2A signaling in ADRA2A/TAAR1 hetero-oligomers.
A 3.3-V CMOS 10.7-MHz sixth-order bandpass ΣΔ modulator with 74-dB dynamic range (2001)

A 3.3-V bandpass /spl Sigma//spl Delta/ modulator for IF sampling at 10.7 MHz in digital radio applications has been developed. The modulator presents a sixth-order single-loop architecture and features a 74-dB dynamic range in a 2OO-kHz signal bandwidth (FM signal), while for a 9-kHz signal bandwidth (AM signal) the dynamic range is 88 dB. The modulator has been integrated in a standard 0.35-/spl mu/m CMOS technology using switched-capacitor technique and consumes 76 mW from a single 3.3V supply.
Towards tagging and categorization for micro-blogs (2010)

Paper presented at the 21st National Conference on Artificial Intelligence and Cognitive Science (AICS 2010), Galway, Ireland, 30 August - 1 September, 2010
SAND TRANSPORT KINEMATICS ON THE TEXAS CONTINENTAL SHELF DURING HURRICANE CARLA, SEPTEMBER 1961 (1989)

Abstract Using available wind, tide, and wave data, it has been possible to reconstruct the kinematics of sand transport during Hurricane Carla, which made landfall at Pass Cavallo, Texas in September, 1961. The analysis indicates that the peak bed shear stress occurred just prior to hurricane landfall. The quasi-steady shelf flow was driven by the wind-induced sea-level slope and consequent hydrostatic pressure gradient forces. The downwelling bottom current probably was oriented obliquely offshore and along-shelf to the southwest. Integration of hindcast wave data with the proposed bottom flow patterns allows development of a descriptive model for the combined-flow transport pathway for sand and silt. This model suggests a regional transport pattern characterized by offshore transport from shoreface sources near the point of hurricane landfall and weak onshore flow on the southern part of the Texas shelf. This kinematic reconstruction is compatible with the observed strike-trending morphology of a thin (&amp;lt; 10 cm), regional sand bed deposited during the storm. The shelf sand transport model developed here differs considerably from an earlier explanation for the Carla sand bed which invokes turbidity currents generated during the ebb phase of the storm surge following hurricane landfall. The combined-flow reconstruction indicates that it is unnecessary to call upon post-storm processes to explain the occurrence or areal distribution of the sand bed deposited during this storm.
Hitting-sets for ROABP and Sum of Set-Multilinear circuits (2014)

We give a $n^{O(\log n)}$-time ($n$ is the input size) blackbox polynomial identity testing algorithm for unknown-order read-once oblivious algebraic branching programs (ROABP). The best result known for this class was $n^{O(\log^2 n)}$ due to Forbes-Saptharishi-Shpilka (STOC 2014), and that too only for multilinear ROABP. We get rid of their exponential dependence on the individual degree. With this, we match the time-complexity for the unknown order ROABP with the known order ROABP (due to Forbes-Shpilka (FOCS 2013)) and also with the depth-$3$ set-multilinear circuits (due to Agrawal-Saha-Saxena (STOC 2013)). Our proof is simpler and involves a new technique called basis isolation. The depth-$3$ model has recently gained much importance, as it has become a stepping-stone to understanding general arithmetic circuits. Its restriction to multilinearity has known exponential lower bounds but no nontrivial blackbox identity tests. In this paper, we take a step towards designing such hitting-sets. We give the first subexponential whitebox PIT for the sum of constantly many set-multilinear depth-$3$ circuits. To achieve this, we define notions of distance and base sets. Distance, for a multilinear depth-$3$ circuit, measures how far are the partitions from a mere refinement. We design a hitting-set in time $n^{O(d \log n)}$ for $d$-distance. Further, we give an extension of our result to models where the distance is large but it is small when restricted to certain base sets (of variables). We also explore a new model of ROABP where the factor-matrices are invertible (called invertible-factor ROABP). We design a hitting-set in time poly($n^{w^2}$) for width-$w$ invertible-factor ROABP. Further, we could do without the invertibility restriction when $w=2$. Previously, the best result for width-$2$ ROABP was quasi-polynomial time (Forbes-Saptharishi-Shpilka, STOC 2014).
Identification of ageing biomarkers in human dermis biopsies by thermal analysis (DSC) combined with Fourier transform infrared spectroscopy (FTIR/ATR) (2017)

DSC and FTIR are well-suited techniques to characterize human skin, giving accurate results with a high reproducibility. The combination of these techniques is useful for a better understanding of human skin modifications with intrinsic and extrinsic ageing.
Thermodynamic analysis of capillary flows in the presence of hydrodynamic slip (2010)

Abstract A thermodynamic description of liquid flows in capillaries with hydrodynamic slip at the solid–liquid interface is given. Slip over the capillary wall brings into play surface interactions and therefore involves interfacial energy and entropy. Energy and entropy balance equations are written so as to take into account surface effects. The two relations constitute a general mathematical model that allows readily analyzing various situations and to explore the behavior of such thermodynamic process. The main result derived concerns the existence of a capillary pressure of slip; slip occurrence leads to a pressure decrease in the flow and might cause cavitation. The variation in magnitude of the slip effect, viewed as a thermodynamic transformation, may take place irreversibly. Slip irreversibility and the probable occurrence of a two‐phase flow regime are possible factors that may cause additional pressure drop. © 2010 American Institute of Chemical Engineers AIChE J, 2011
Wasp venom peptide, synoeca‐MP, from Synoeca surinama shows antimicrobial activity against human and animal pathogenic microorganisms (2019)

Abstract The rising number of multidrug‐resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca‐MP consists of an antimicrobial peptide (AMP) classified as a mastoparan, which was isolated from the venom of Synoeca surinama , a social wasp. Synoeca‐MP presented a potent antimicrobial activity, with values of MIC 50 and MIC 90 against methicillin‐resistant Staphylococcus aureus —MRSA (1.9 and 2.2 μM), Escherichia coli ESBL (2.0 and 2,1 μM), vancomycin‐resistant Enterococcus faecalis (8.3 and 17.1 μM), Pseudomonas aeruginosa metallo‐ß‐lactamase (5.2 and 5.9 μM), and Klebsiella pneumoniae KPC (3.5 and 4.7 μM). Synoeca‐MP was also tested against six Candida species, with MICs varying from 10 to 40 μM. Moreover, the structural prediction for Synoeca‐MP demonstrated a cationic α‐helix capable of interacting with in silico membranes and low hemolytic activity. Due to its antimicrobial activity, synoeca‐MP shows potential as an adjuvant to antibiotics and antifungals commonly used in antibiotic therapies.