gebhart/patrepeval huggingface dataset:
Alliance in two telephone-administered treatments: Relationship with depression and health outcomes. (2007)

The present study examined the relationship between therapeutic alliance and both depression and health outcomes in a randomized clinical trial of 2 telephone-administered treatments with 97 clients with multiple sclerosis (MS). The 16-week, manualized treatments compared were telephone-administered cognitive-behavioral therapy (T-CBT) and telephone-administered supportive emotion focused therapy (T-SEFT), an experiential treatment. Alliance scores were significantly higher in T-CBT compared with T-SEFT, and treatment moderated the relationship between alliance and outcome on some of the measures. Specifically, alliance predicted subsequent improvements in depression within the T-CBT condition, but not in T-SEFT, controlling for early symptom change. The authors found a similar trend for alliance and MS-related disability in T-CBT only. This is one of the first studies to examine the role of alliance in outcome for the emerging modality of telephone therapy and one of the few to relate alliance to health outcomes. The findings suggest that the therapist-client relationship is important to improvement in telephone therapy and that the role of alliance in outcome may vary by treatment approach.
Polyborazines-Derived Boron Nitride Fibers (2005)

International audience
Abstract 3908: Universal genetic and transcriptomic concordance metrics to validate patient-derived tumor organoid models (2020)

Abstract Background Patient derived tumor organoids (TOs) are emerging as potential models to elucidate mechanisms of tumor biology and therapeutic response. Here, we establish pan-cancer metrics for validation of genetic and transcriptomic recapitulation, and concordance of an organoid to its native tumor. Methods/Results We sequenced 50 tumor/TO pairs from 12 cancer types using the Tempus xT DNAseq panel and transcriptome RNAseq platforms. Concordance metrics between tumors and TOs were derived for genomic variants called by the DNA xT platform and comparative ratios were calculated for all detected somatic variants. Across all sequenced pairs, somatic variant detection concordance between any mutation identified in primary tissues and tumor organoids resulted in a mean value of 88.1%. Somatic primary tumor variant recapitulation, the percent of somatic variants identified in the primary tumors that were also detected in the TO, averaged 96.3%. In addition to genetic concordance, DNAseq can identify and track clonal and subclonal diversity from source material to TO. In particular, we observed that &amp;gt;90% of source tumor/TO pairs harbor variants with allelic fractions &amp;lt;40% in both the sequenced TO and primary tumor tissue, suggesting intra-tumor heterogeneity in subclonal cell populations is maintained. TOs and primary tumor transcriptomic profiles were compared by dimensionality reduction approaches (i.e. Uniform Manifold Approximation and Projection (UMAP), and Principal Components Analysis (PCA)) as well as differential expression analysis between cancer types. Overall, TOs recapitulated expected transcriptional programs of their tumor type as evidenced by UMAP and PCA as well as upregulation of defining pathways, such as estrogen receptor pathways in breast cancer TOs (ssGSEA p-values ranging from 0.004 to 5 × 10−5 for 5 gene ontology estrogen response pathways when compared to non-breast cancer TOs). Conclusion Determining genomic and transcriptomic concordance of TOs to source tumors is essential to confirm the validity of a given patient derived model. Our approach establishes metrics through key genomic features identified from routine next-generation sequencing data and can be extended beyond model validation to tracking clonal evolution over time in the presence or absence of therapeutic selection pressures. Our metrics may also serve as a critical quality control step if TOs are utilized in the clinical setting for personalized medicine. Citation Format: Brandon L. Mapes, Joshua SK Bell, Lee F. Langer, Robert Huether, Catherine Igartua, Veronica Sanchez-Freire, Robert Tell, Jeffrey A. Borgia, Ashiq Masood, Ameen A. Salahudeen. Universal genetic and transcriptomic concordance metrics to validate patient-derived tumor organoid models [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3908.
Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development (2001)

Various types of collagen have been identified as potential ligands for the two mammalian discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Here, we used a recombinant fusion protein between the extracellular domain of DDR1 and alkaline phosphatase to detect specific receptor binding sites during mouse development. Major sites of DDR1-binding activity, indicative of ligand expression, were found in skeletal bones, the skin, and the urogenital tract. Ligand expression in the uterus during implantation and in the mammary gland during pregnancy colocalized with the expression of the DDR1 receptor. The generation of DDR1-null mice by gene targeting yielded homozygous mutant animals that were viable but smaller in size than control littermates. The majority of mutant females were unable to bear offspring due to a lack of proper blastocyst implantation into the uterine wall. When implantation did occur, the mutant females were unable to lactate. Histological analysis showed that the alveolar epithelium failed to secrete milk proteins into the lumen of the mammary gland. The lactational defect appears to be caused by hyperproliferation and abnormal branching of mammary ducts. These results suggest that DDR1 is a key mediator of the stromal-epithelial interaction during ductal morphogenesis in the mammary gland.
Optimal design of bus converter in on-board distributed power architecture (2007)

The power supply system which requires the low-voltage / high-current output has been changing from conventional centralized power system to distributed power system. The distributed power system consists of bus converter and POL. The most important factor is the system stability in bus architecture design. The overlap between the output impedance of bus converter and input impedance of POL causes system instability, and it has been an actual problem. Increasing the bus capacitor, system stability can be reduced easily. However, due to the limited space on the system board, increasing of bus capacitors is impractical. The urgent solution of the issue is desired strongly. This paper presents the output impedance design for on-board distributed power system by means of three control schemes of bus converter. The output impedance peak of the bus converter and the input impedance of the POL are analyzed, and it is conformed by experimentally for stability criterion. Furthermore, the design process of each control schemes for system stability is proposed.
Glycemic index and phenolics of partially-baked frozen bread with sourdough (2010)

Different lactic acid bacteria starters were used to prepare sourdough to make partially-baked frozen wholemeal wheat bread. The sourdough was prepared with a pure culture of Lactobacillus plantarum or with commercial starters containing Lactobacillus brevis combined with Saccharomyces cerevisiae var. chevalieri (LV4), Lactobacillus fermentum (PL1), or Lactobacillus fermentum with phytase (PL3). We determined the acetic and lactic acid concentrations in sourdough, bread chemical composition, total phenolics content and glycemic index (GI) in vivo. Depending on the starter, the lactic to acetic acid ratio in the sourdough was significantly different. The GI of control bread without sourdough (70) was significantly higher than that of bread containing sourdough prepared with LV4 starter (50), PL1 starter (56) or PL3 starter (56), but not from bread with L. plantarum sourdough (60). The addition of 10% sourdough with a lower molar ratio of lactic to acetic acid ( ≤ 4) and higher total phenolics content is preferable for generating bread with medium and low GI.
Comparisons of the immunological properties of two structural polypeptides of type C RNA viruses endogenous to old world monkeys (1976)

Immunologically very closely related type C RNA viruses are endogenous to the domestic cat and to an old world primate, the baboon. In the present studies, radioimmunological techniques have been developed for detection of the 15,000 and 30,000 molecular weight (MW) polypeptides of each virus. The much more pronounced type-specific antigenic determinants of the lower MW polypeptides made it possible to readily differentiate these viruses from each other as well as from a type C virus isolate from a second baboon species. Normal rhesus monkey tissues were partially purified and shown to contain a reactivity with MW and immunological properties similar to that of the baboon virus 30,000 MW polypeptide. Despite a similar degree of purification, antigenic reactivity like that of the baboon virus 15,000 MW polypeptide was undetectable even in the brodest immunological tests available for this polypeptide. The present findings indicate that the immunological properties of two structural polypeptides of closely related viruses endogenous to primate and feline species have undergone different rates of antigenic change in the course of evolution within their respective host cell genome.
The synthesis of the monomethyl derivatives of benzo[b]naphtho[2,3‐d]thiophene (1982)

Abstract The synthesis of all the monomethyl derivatives of benzo[ b ]naphtho[2,3‐ d ]thiophene is described.
Characterization and Primary Structure of a Fatty Acid-Binding Protein and Its Isoforms from the Liver of the Amphibia, Rana catesbeiana (1999)

Fatty acid-binding protein (FABP) was purified from the liver of the Amphibia, Rana catesbeiana, by gel filtration and ion-exchange chromatography. The complete primary structure of the frog liver FABP was determined by protein analysis. Two isoforms, I and II, were separated by reversed phase HPLC, and found to differ by 10 atomic mass units as measured by ion-spray ionization mass spectrometry. A detailed analysis of enzymatic peptides revealed a single Pro (isoform I)/Ser (isoform II) replacement at position 16. It seems remarkable that a rather neutral point mutation results in the nearly complete separation of the two isoforms by reversed phase chromatography. Homology modeling suggests the location of this site on the first helix of the helix-turn-helix domain and the presence of a single thiol group of cysteine-91 at the inside of the ligand-binding cavity. Binding studies using a natural fluorescent fatty acid, cis-parinaric acid, showed a lower Kd value for the serine form and large enhancement of fluorescence intensity upon glutathione-thiolation at cysteine-91. Examination of phylogenetic relationships identified the frog liver protein as a mammalian liver type FABP, and suggested a change in the vertebrate liver FABP gene expression at the bony fish/cartilagenous fish boundary.
Thoughts on the International Cooperation and Exchanges of Chinese Research Universities (2009)

More prominent in the 21st century than ever are the internationalization of the competition for talents, the globalization of their mobility, and the diversity of the demand for them. This article analyzes the major features and content of the international cooperation and exchanges, and further discusses their tactics and measures in the process of internationalization of Chinese research universities, based on the latter's really situations.
Plasminogen Activator Inhibitor-1 and Vascular Disease in Diabetes Mellitus (2001)

Atherosclerosis is a major cause of morbidity and mortality in patients with both insulindependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. The impact of vascular disease on patients with diabetes is staggering, accounting for nearly 80% of deaths and more than 70% of hospitalizations.
Xsim: unified regional approach to compact modeling for next generation CMOS (2005)

This paper describes the approaches in the development of Xsim, a unified regional threshold-voltage-based model for deep-submicron MOSFETs. In comparison to popular surface-potential-based models, our approach has the advantages of correlation to technology data, minimum data and one-iteration extraction, single-piece charge models from accumulation to strong inversion with extendibilily to poly-depletion and strained-Si, as well as selectable accuracy with the same parameter set.
Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients (2012)

Abstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts. Asparaginase in its various forms is an important component of treatment regimens for pediatric ALL. Recently, interest and use of asparaginase in adult patients with ALL has increased, particularly in young adults. There is much less information on asparaginase use and toxicity in adult compared with pediatric populations. This review surveys prior published studies of the three most commonly used asparagine preparations as used in adult patients, and discusses important toxicities encountered in adult patients who receive asparaginase preparations. Keywords: asparaginase, leukemia, adults, children
62.2: Mechanical Reliability of LCD Panels under Dynamic Loading (2004)

Abstract An important aspect of mechanical reliability of LCD panels is to understand and quantify their response to impact loading. This paper studies the behavior of 17″ modules impacted by a spherical ball traveling at a speed of up to ∼1 m/sec. At this velocity, the deformation response of the module system is significantly different from that during quasi‐static loading. In view of much shorter duration of impact test, the LCD panels can sustain relatively large loads without any measurable slow crack growth. The test data show that the dynamic strength of these panels, estimated from fracture mirror, is significantly higher than their quasi‐static strength. With higher strength and immeasurable slow crack growth the LCD panels should not experience cumulative damage during multiple impact loading implying that their mechanical reliability under such loading is excellent.
Advanced aberration control in projection optics for double patterning (2009)

Wavefront aberrations of the projection optics induce unignorable focus and overlay errors dependent on the shape of the device pattern and illumination settings. Thus, the 32nm node and the subsequent double patterning lithographic generation require ever more stringent control of aberrations. For the most recent exposure tools with polarized illumination and high throughput capabilities in particular, due attention needs to be paid to the influences of aberrations caused by polarization and exposure load. A system for measuring and correcting polarization aberrations and lens heating aberrations has been developed, and its technical details and application examples are presented in this paper. Furthermore, improvement in aberration control on the next generation exposure tool compatible with double patterning is stated as well.
In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors (2012)

The Akt kinase family, consisting of three isoforms in humans, is a well-validated class of drug target. Through various screening campaigns in academics and pharmaceutical industries, several promising inhibitors have been developed to date. However, due to the mechanistic and structural similarities of Akt kinases, it is yet a challenging task to discover selective inhibitors against a specific Akt isoform. We here report Akt-selective and also Akt2 isoform-selective inhibitors based on a thioether-macrocyclic peptide scaffold. Several anti-Akt2 peptides have been selected from a library by means of an in vitro display system, referred to as the RaPID (Random nonstandard Peptide Integrated Discovery) system. Remarkably, the majority of these "binding-active" anti-Akt2 peptides turned out to be "inhibitory active", exhibiting IC(50) values of approximately 100 nM. Moreover, these peptides are not only selective to the Akt kinase family but also isoform-selective to Akt2. Particularly, one referred to as Pakti-L1 is able to discriminate Akt2 250- and 40-fold over Akt1 and Akt3, respectively. This proof-of-concept case study suggests that the RaPID system has a tremendous potential for the discovery of unique inhibitors with high family- and isoform-selectivity.
Revisiting congestion control for multipath TCP with shared bottleneck detection (2016)

Multipath TCP (MPTCP) enables the simultaneous use of multiple links for bandwidth aggregation, better resource utilization and improved reliability. Its coupled congestion control intends to reap the increased bandwidth of multiple links, while avoiding being more aggressive than regular TCP flows on every used link. We argue that this leads to a very conservative behavior when paths do not share a bottleneck. Therefore, in this paper, we first quantify the penalty of the coupled congestion control for links that do not share a bottleneck. Then, in order to overcome this penalty, we design and implement a practical shared bottleneck detection (SBD) algorithm for MPTCP, namely MPTCP-SBD. Through extensive emulations, we show that MPTCP-SBD outperforms all currently deployed MPTCP coupled congestion controls by accurately detecting bottlenecks. For the non-shared bottleneck scenario, we observe throughput gains of up to 40% with two subflows and the gains increase significantly as the number of subflows increase, reaching more than 100% for five subflows. Furthermore, for the shared bottleneck scenario, we show that MPTCP-SBD remains fair to TCP. We complement the emulation results with real-network experiments justifying its safeness for deployment.
Safety and Pharmacokinetics of Palivizumab Therapy in Children Hospitalized with Respiratory Syncytial Virus Infection (2004)

Intravenous palivizumab was safe and well-tolerated in children hospitalized with RSV disease. A single 15-mg/kg dose achieved serum palivizumab concentrations above the 25- to 30-microg/mL concentration associated with 2-log reduction of pulmonary RSV titer in the cotton rat model.
On the performance of the Baxter research robot (2016)

The rise of collaborative industrial robotics in the past few years is poised to have a significant impact on manufacturing. Many have joined the movement toward developing a more sustainable and affordable collaborative robotic workforce that can safely work alongside humans; perhaps, none more so than Rethink Robotics. This paper provides a performance assessment of Rethink's Baxter research robot: its kinematic precision was compared experimentally to that of a conventional industrial arm utilizing a point-to-point motion test and writing task. In addition, the Denavit-Hartenberg (DH) parameters were determined and verified in order to model the kinematic chains of the robot arms. Finally, the yield of pick and place tasks consistent with the 2015 IEEE Amazon's Picking Challenge were assessed. Results show that while Baxter's precision is limited, its ability to handle common household-size items in semi-structured environments is a great asset.
Bottom-Up Strategy to Forecast the Drug Location and Release Kinetics in Antitumoral Electrospun Drug Delivery Systems (2023)

Electrospun systems are becoming promising devices usable for topical treatments. They are eligible to deliver different therapies, from anti-inflammatory to antitumoral. In the current research, polycaprolactone electrospun membranes loaded with synthetic and commercial antitumoral active substances were produced, underlining how the matrix-filler affinity is a crucial parameter for designing drug delivery devices. Nanofibrous membranes loaded with different percentages of Dacarbazine (the drug of choice for melanoma) and a synthetic derivative of Dacarbazine were produced and compared to membranes loaded with AuM1, a highly active Au-complex with low affinity to the matrix. AFM morphologies showed that the surface profile of nanofibers loaded with affine substances is similar to one of the unloaded systems, thanks to the nature of the matrix-filler interaction. FTIR analyses proved the efficacy of the interaction between the amidic group of the Dacarbazine and the polycaprolactone. In AuM1-loaded membranes, because of the weak matrix-filler interaction, the complex is mainly aggregated in nanometric domains on the nanofiber surface, which manifests a nanometric roughness. Consequently, the release profiles follow a Fickian behavior for the Dacarbazine-based systems, whereas a two-step with a highly prominent burst effect was observed for AuM1 systems. The performed antitumoral tests evidence the high-cytotoxic activity of the electrospun systems against melanoma cell lines, proving that the synthetic substances are more active than the commercial dacarbazine.
Coral reef canary (2007)

ADVERTISEMENT RETURN TO ISSUECOMMENTNEXTCoral reef canaryJerald L. SchnoorCite this: Environ. Sci. Technol. 2007, 41, 9, 3031Publication Date (Web):May 1, 2007Publication History Published online1 May 2007Published inissue 1 May 2007https://pubs.acs.org/doi/10.1021/es072521thttps://doi.org/10.1021/es072521tnewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views308Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (91 KB) Get e-Alertsclose Get e-Alerts
Supplementary Figure 1 from Effect of Low-Fat Diet on Development of Prostate Cancer and Akt Phosphorylation in the Hi-Myc Transgenic Mouse Model (2023)

Supplementary Figure 1 from Effect of Low-Fat Diet on Development of Prostate Cancer and Akt Phosphorylation in the Hi-Myc Transgenic Mouse Model