gebhart/patrepeval huggingface dataset:
A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns (2003)

The myc proto-oncogenes encode transcriptional regulators whose inappropriate expression is correlated with a wide array of human malignancies. Up-regulation of Myc enforces growth, antagonizes cell cycle withdrawal and differentiation, and in some situations promotes apoptosis. How these phenotypes are elicited is not well understood, largely because we lack a clear picture of the biologically relevant downstream effectors. We created a new biological system for the optimal profiling of Myc target genes based on a set of isogenic c-myc knockout and conditional cell lines. The ability to modulate Myc activity from essentially null to supraphysiological resulted in a significantly increased and reproducible yield of targets and revealed a large subset of genes that respond optimally to Myc in its physiological range of expression. The total extent of transcriptional changes that can be triggered by Myc is remarkable and involves thousands of genes. Although the majority of these effects are not direct, many of the indirect targets are likely to have important roles in mediating the elicited cellular phenotypes. Myc-activated functions are indicative of a physiological state geared toward the rapid utilization of carbon sources, the biosynthesis of precursors for macromolecular synthesis, and the accumulation of cellular mass. In contrast, the majority of Myc-repressed genes are involved in the interaction and communication of cells with their external environment, and several are known to possess antiproliferative or antimetastatic properties.
A multiplexed single-photon instrument for routine measurement of time-resolved fluorescence anisotropy (1987)

The authors report a new type of instrument, the Edinburgh Instruments Model 2997 differential fluorometer, for the measurement of the decay of fluorescence anisotropy. The instrument incorporates three multiplexed detection channels for simultaneous measurement of two polarised fluorescence decays and the excitation pulse, using time-correlated single-photon counting. This arrangement corrects automatically for temporal and intensity fluctuations of the spark source. A study of the probe 1,6-diphenyl-1,3,5-hexatriene (DPH) in a white oil reveals that the instrument can measure rotational correlation times with subnanosecond time resolution in a third of the time of conventional methods.
[Effect of psychotropic agents on the manifestation of the morphine abstinence syndrome in mice]. (1980)

Abstinence syndrome pattern produced by withdrawal of morphine injections in doses of 240 mg/kg daily was studied in experiments on mice. Pirroksan, butyroxan and carbidine (10 mg/kg intraperitoneally) inhibited manifestations of morphine withdrawal in an "open field" situation and depressed jumping activity. Phenazepam (20 mg/kg) depressed emotional hyperactivity in abstinent animals.
Voice conversion based on piecewise linear conversion rules of formant frequency and spectrum tilt (2002)

The paper proposes a new algorithm to convert the speech of one speaker so that it sounds like that of another. To modify formant frequencies and spectral tilt, the algorithm provides piecewise linear conversion rules which make it possible to control spectrum parameters in detail. Because the rules are statistically generated using training data, reliability of the conversion rules are guaranteed, and the rules are automatically generated for any pair of speakers. According to the conversion rules, formant frequencies and spectral tilt are modified by a formant modification algorithm based on the minimization of spectral distortion. Evaluation by listening tests shows that the proposed algorithm makes it possible to convert speaker individuality while maintaining high quality.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Inflammatory Chemokine CCL5 and Cancer Progression (2014)

Until recently, inflammatory chemokines were viewed mainly as indispensable "gate keepers" of immunity and inflammation. However, updated research indicates that cancer cells subvert the normal chemokine system and these molecules and their receptors become important constituents of the tumor microenvironment with very different ways to exert tumor-promoting roles. The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies aimed to inhibit the binding of CCL5 to CCR5, to inhibit CCL5 secretion, or to inhibit the interactions among tumor cells and the microenvironment leading to CCL5 secretion.
Comparison between client-side and server-side rendering in the web development (2020)

Abstract Mandatory servers for universal applications that is accessible to number of users may be a deterrent for the corporation and excessive for small applications even though it could bring the compatibility advantages. Knowing that demand of web application increases to provide convenience and ease of use to the users, client side rendering comes to create software more fast and efficient. It has been done by redirecting the request towards an HTML file then the server will give messages without any content or a loading screen until the device takes all JavaScript to allow the browser compiling everything before displaying the content. Therefore, the purpose of this paper is to analyse the comparison between client side and server side method in the respect of technical aspects in term of first content paint, speed index, time to interactive, first meaningful paint, first idle CPU and estimated input latency that present better performance with 2.1s, 2.0s, 2.2s, 2.1s, 2.2s and 20ms respectively on server side. It also provide better result based on Google Audit with 100% performance, 48% accessibility, 93% best practice and 89% of search engine optimization (SEO).
Envelope Protection for In-Flight Ice Contamination (2009)

Fatal loss-of-control (LOC) accidents have been directly related to in-flight airframe icing. The prototype system presented in this paper directly addresses the need for real-time onboard envelope protection in icing conditions. The combinations of a-priori information and realtime aerodynamic estimations are shown to provide sufficient input for determining safe limits of the flight envelope during in-flight icing encounters. The Icing Contamination Envelope Protection (ICEPro) system has been designed and implemented to identify degradations in airplane performance and flying qualities resulting from ice contamination and provide safe flight-envelope cues to the pilot. Components of ICEPro are described and results from preliminary tests are presented.
Human–Computer Interaction (2001)

This chapter contains sections titled: Overview Ergonomics Cognitive Design Social, Organizational, and Management Factors Iterative Design References
Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity (2019)

Ab-dependent cellular cytotoxicity (ADCC) is one of the most important effector mechanisms of tumor-targeting Abs in current immunotherapies. In ADCC and other Ab-dependent activation of myeloid effector cells, close cell-cell contact (between effector and target cell) and formation of immunological synapses are required. However, we still lack basic knowledge on the principal factors influencing ADCC potential by therapeutic Abs. In this study we investigated the combined roles of five factors affecting human NK cell-mediated ADCC, namely: 1) Ag density, 2) target cell membrane composition, 3) IgG FcγR polymorphism, 4) FcγR-blocking cytophilic Abs, and 5) Ab fucosylation. We demonstrate that the magnitude of NK cell-mediated ADCC responses is predominantly influenced by Ag density and Ab fucosylation. Afucosylation consistently induced efficient ADCC, even at very low Ag density, where fucosylated target Abs did not elicit ADCC. On the side of the effector cell, the FcγRIIIa-Val/Phe158 polymorphism influenced ADCC potency, with NK cells expressing the Val158 variant showing more potent ADCC. In addition, we identified the sialic acid content of the target cell membrane as an important inhibitory factor for ADCC. Furthermore, we found that the presence and glycosylation status of aspecific endogenous Abs bound to NK cell FcγRIIIa (cytophilic Abs) determine the blocking effect on ADCC. These five parameters affect the potency of Abs in vitro and should be further tested as predictors of in vivo capacity.
Study for the standardization of Pyritum and comparison composition before and after using processed method on pyritum (2003)

Objectives: This experimental study has been done to compare the pyritum's composition before and after using processing method. Pyritum has a quality for strengthening the bones and binding the muscles, alleviating pain by removing blood stasis, also. Methods: I studied the natural copper and processed natural copper by vinegar to compare the compositions and its' character. Results: Natural copper(pyritum) is a pyrite which has a sulfide mineral. Natural copper(pyrite) contains a main ingredients ＞60.00%. Processed natural copper which is heated and soaked in vinegar changes to hematite and small ingredients which ratio is changed to high but not significantly changed in . Conclusion: Pyritum is supposed to be a natural products (natural copper) or an oriental medical sulfide mineral (chalcopyrite) of an oriental medical oxide(cuprite) and a steel sulfide which contains copper(pyrite), in fact, pyrite is a steel sulfide and limonite is oxided from pyrite.
Aldol Reaction of Enol Esters Catalyzed by Cationic Species Paired with Tetrakis(pentafluorophenyl)borate. (2000)

The crossed aldol reaction of enol esters, which are weak carbon nucleophiles, with aldehydes was effectively carried out under mild conditions by using a catalytic amount of several cationic species paired with tetrakis(pentafluorophenyl)borate.
Porphyrin aggregates decorated MWCNT film for solar light harvesting: influence of J- and H-aggregation on the charge recombination resistance, photocatalysis, and photoinduced charge transfer kinetics (2017)

J- and H-aggregates of zinc tetraphenylporphyrin (ZnTPP) on carbon nanotube films (CNTFs) were prepared using the mixed solvent method. This resulted in completely different structures, such as the four-leaf clover and flower, on the CNTF, which were observed by recording SEM images. Characteristic changes in the electronic spectra of the ZnTPP monomer appeared when it underwent J- and H-aggregation. The measured photocurrent significantly varied for the same molecule when it was aggregated in two different ways on ITO and ITO/CNTF. The electron recombination resistance of the two aggregates, which was investigated using electrochemical impedance spectroscopy, was also different. The photocatalytic efficiency of the J- and H-aggregates was examined by performing methylene blue dye decoloration studies. In addition, a scanning electrochemical microscope was used to investigate the photoinduced charge transfer kinetics of the J- and H-aggregates at the electrode/electrolyte interface as a fresh attempt. The heterogeneous charge transfer constants for the J- and H-aggregates in the presence of light at varied intensities were calculated. Thereby, striking differences in the photophysical, photocatalytic, and photoelectrochemical properties of the J- and H-aggregates were visualized throughout our studies.
A moving-target defense strategy for Cloud-based services with heterogeneous and dynamic attack surfaces (2014)

Due to deep automation, the configuration of many Cloud infrastructures is static and homogeneous, which, while easing administration, significantly decreases a potential attacker's uncertainty on a deployed Cloud-based service and hence increases the chance of the service being compromised. Moving-target defense (MTD) is a promising solution to the configuration staticity and homogeneity problem. This paper presents our findings on whether and to what extent MTD is effective in protecting a Cloud-based service with heterogeneous and dynamic attack surfaces — these attributes, which match the reality of current Cloud infrastructures, have not been investigated together in previous works on MTD in general network settings. We 1) formulate a Cloud-based service security model that incorporates Cloud-specific features such as VM migration/snapshotting and the diversity/compatibility of migration, 2) consider the accumulative effect of the attacker's intelligence on the target service's attack surface, 3) model the heterogeneity and dynamics of the service's attack surfaces, as defined by the (dynamic) probability of the service being compromised, as an S-shaped generalized logistic function, and 4) propose a probabilistic MTD service deployment strategy that exploits the dynamics and heterogeneity of attack surfaces for protecting the service against attackers. Through simulation, we identify the conditions and extent of the proposed MTD strategy's effectiveness in protecting Cloud-based services. Namely, 1) MTD is more effective when the service deployment is dense in the replacement pool and/or when the attack is strong, and 2) attack-surface heterogeneity-and-dynamics awareness helps in improving MTD's effectiveness.
Air Pollution: Involvement of Oxygen Radicals (A Mini Review) (1991)

In the past decades air pollution has increased worldwide. We also gained more insight into the complex interactions between different air pollutants in the atmosphere as well as their effects on living cells and organisms. It also has been unequivocally shown by several groups in different countries that oxy radicals play an outstanding role in the interconversion of air pollutants as well as during the manifestation of toxic effects. Not only living systems are affected by air pollutants, but also inorganic systems such as buildings and sculptures. In the following overview the most important reactions occurring in the atmosphere as well as effects of oxidative gaseous compounds and particles such as diesel soot and asbestos will be discussed.
Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly (2008)

Molecular chaperones of the heat shock protein 70 (Hsp70) family counteract protein misfolding in a variety of neurodegenerative disease models. To determine whether human Hsp70 exerts similar effects on the aggregation of alpha-synuclein (alpha-Syn), the key component of insoluble fibrils present in Parkinson's disease, we investigated alpha-Syn fibril assembly in the presence of Hsp70. We found in vitro assembly was efficiently inhibited by substoichiometric concentrations of purified Hsp70 in the absence of cofactors. Experiments using alpha-Syn deletion mutants indicated that interactions between the Hsp70 substrate binding domain and the alpha-Syn core hydrophobic region underlie assembly inhibition. This assembly process was inhibited prior to the elongation stage as we failed to detect any fibrils by electron microscopy. In addition, fluorescence polarization and binding assays suggest that Hsp70 recognizes soluble alpha-Syn species in a highly dynamic and reversible manner. Together, these results provide novel insights into how Hsp70 suppresses alpha-Syn aggregation. Furthermore, our findings suggest that this critical step in Parkinson's disease pathogenesis may be subject to modulation by a common molecular chaperone.
Development of Pitching Mechanism in Boccia Robot (2018)

We propose to use a robotic interface with boccia which is a disabled sport so that a wider range of people can enjoy boccia together. In this paiper, we have developed a pitching mechanism capable of lobbing and rolling a ball in the boccia robot, and conducted a performance evaluation experiments.
A prospective study of the influence of α thalassaemia on morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in Gambian children (1993)

The protective effect of alpha thalassaemia (-alpha/alpha alpha) against morbidity from falciparum malaria was assessed in a prospective study of rural Gambian children. The gene frequency for single alpha-globin gene deletions was 0.12. Malariometric indices measured during cross-sectional surveys and morbidity from malaria determined by weekly surveillance were similar in children with alpha thalassaemia and in those with a normal alpha-globin genotype. However, the small number of children who carried both alpha thalassaemia and the sickle cell trait had fewer clinical episodes of malaria than children with the sickle cell trait alone. Specific antibody responses and cell-mediated immune responses in vitro to defined Plasmodium falciparum antigens were measured in children participating in the study. In general, there was no evidence of an increased prevalence or intensity of humoral or cell-mediated immune responses to the malaria antigens studied in children heterozygous for alpha thalassaemia compared with children with a normal alpha-globin genotype.
Color and Light (1972)

Man's ability to discriminate colors increases both his enjoyment and appreciation of the world around him. Because color is such a significant factor in the appearance of an object, it is an important characteristic of any paint. Appearance is one quality of a product that every customer can judge for himself. No matter how good the physical properties of a paint, if the color does not meet the expectation of the customer, he will think the finished product unsatisfactory. Color is often thought to be a property of the paint itself, and, to a degree, it is. Actually it is more complex than that for color of a paint depends on three things: (1) the spectral reflectance of the paint, (2) the spectral composition of the light in which the paint is viewed, and (3) the spectral sensitivity of the eye of the observer. For these reasons matching the color of a paint or other material requires considering all three and not merely the spectral characteristic of the material.
Magnetic and superconducting proximity effects on the transport properties of hybrid heterostructures (Conference Presentation) (2017)

We theoretically investigate the interplay between SOFs and proximity-induced magnetism in hybrid SM/F heterostructures (SM and F stand for semiconductor ferromagnet, respectively) as well as its effect on spectral and transport properties. The anisotropic spin-dependent transport leads to the emergence of novel magnetoresistive phenomena in planar SM/F multi-terminal devices, where both the longitudinal and transverse Hall-like responses become anisotropic with respect to the magnetization orientation. We also investigate the superconducting proximity effect in SM/S heterostructures (S stands for superconductor), where the interfacial SOFs can lead to the emergence of triplet pairing even for s-type S materials.
Comparison of SDDs and SiPMs photodetector options for INSERT, a new multi-modality SPECT/MRI system for preclinical and clinical imaging (2013)

A new multi-modality imaging tool is under development in the framework of the INSERT (INtegrated SPECT/MRI for Enhanced Stratification in Radio-chemoTherapy) project, supported by the European Community. A custom SPECT apparatus, used as an insert for commercially available MRI systems, will enhance the treatment of brain tumors (primarily glioma) by offering more effective and earlier diagnosis with potentially better outcome in survival. The project aims to develop two SPECT prototypes, dedicated to preclinical and clinical imaging. The final goal is to fit the complete SPECT detection system into an existing MRI bore (diameter: 20 cm for the preclinical system and 59 cm for the clinical system). In this work, we propose the use of two possible photodetecors for the scintillator readout: Silicon Drift Detectors and Silicon PhotoMultipliers. A comparison between the main parameters of the two technologies as well as simulations about the achievable energy and spatial resolution are presented.
Bedside Tool for Predicting the Risk of Postoperative Dialysis in Patients Undergoing Cardiac Surgery (2006)

Our study identifies the major patient risk factors for postoperative dialysis after cardiac surgery. These risk factors have been converted into a simple, accurate bedside risk tool. This tool should facilitate improved clinician-patient discussions about risks of postoperative dialysis.
Analysis of Optimal Operation about Purifying Magnesium Oxide with Three-phase AC Electric Smelting Furnace (2007)

To the electric smelting furnace for purifying magnesium oxide which is a complex multivariable system with the characteristics of large time-delay and strong nonlinearity,an accurate model for field control is established.Based on the course of electric smelting furnace starting from studying the arc-resistance and bath resistance,a mathematic model of smelting bath power field is set up.The reasonable distribution,bath shape change and optimal operation methods in different stages are essential for improving productivity and quality.Based on studying the periclase crystallization process in the electric magnesite melt mass,the temperature control from outside of the electric smelting furnace is the key factor to produce high-quality electric melt magnesite.
Quantitative Analysis of Cutaneous Malassezia in Atopic Dermatitis Patients Using Real‐Time PCR (2006)

We quantified the cutaneous Malassezia in patients with atopic dermatitis using a real-time PCR assay. Seven to 12 times more Malassezia colonized the head and neck compared to the trunk or limbs, and the species M. globosa and M. restricta accounted for approximately 80% of all Malassezia colonization at any body site.
UWB All-Textile Antenna With Full Ground Plane for Off-Body WBAN Communications (2013)

A fully textile microstrip topology with ultra wideband (UWB) characteristics useful in wireless body area networks (WBAN) is proposed. The antenna is operable within the full UWB band and incorporates a full textile shielding ground plane. The full ground plane is shown to be crucial in maintaining the performance when worn on-body. It successfully reduces any on-body performance degradation, resulting in a very robust structure. A detailed numerical and experimental evaluation of the antenna is performed in free space and on body.
Elucidating the Effects of the Composition on Hydrogen Sorption in TiVZrNbHf-Based High-Entropy Alloys (2020)

A number of high-entropy alloys (HEAs) in the TiVZrNbHf system have been synthesized by arc melting and systematically evaluated for their hydrogen sorption characteristics. A total of 21 alloys with varying elemental compositions were investigated, and 17 of them form body-centered-cubic (bcc) solid solutions in the as-cast state. A total of 15 alloys form either face-centered-cubic (fcc) or body-centered-tetragonal (bct) hydrides after exposure to gaseous hydrogen with hydrogen per metal ratios (H/M) as high as 2.0. Linear trends are observed between the volumetric expansion per metal atom [(<i>V</i>/<i>Z</i>)<sub>fcc/bct</sub> - (<i>V</i>/<i>Z</i>)<sub>bcc/hcp</sub>]/(<i>V</i>/<i>Z</i>)<sub>bcc/hcp</sub> with the valence electron concentration and average Pauling electronegativity (χ<sub>p</sub>) of the alloys. However, no correlation was observed between the atomic size mismatch, δ, and any investigated hydrogen sorption property such as the maximum storage capacity or onset temperature for hydrogen release.