gebhart/patrepeval huggingface dataset:
Heat Shock Protein–Based Therapeutic Strategies Against Human Immunodeficiency Virus Type Infection (1999)

Heat shock proteins (hsps) and cyclophilins (CypA) are intracellular chaperone molecules that facilitate protein folding and assembly. These proteins are selectively expressed in cells following exposure to a range of stress stimuli, including viral infection. Hsp species are highly immunogenic, eliciting humoral, cytotoxic T lymphocyte (CTL), and natural killer (NK) cell responses against viruses, tumours, and infectious diseases. This review discusses the roles of stress proteins in immunity and viral life cycles, vis-à-vis the development of Hsp-based therapeutic strategies against human immunodeficiency virus type-1 (HIV-1) infection. Cumulative findings are cited implicating the requirement of CypA in HIV-1 replication and formation of infectious virions. Studies by our group show the upregulated expression of hsp27 and hsp70 during single-cycle HIV infections. These species redistribute to the cell surface following HIV-infection and heat stress, serving as targets for NK and antibody-dependent cellular cytotoxicity. Co-immunoprecipitation and Western blot studies show that hsp27, hsp70, and hsp78 complex with HIV-1 viral proteins intracellularly. Hsp70, hsp56, and CypA are assembled into HIV-1 virions. The ability of hsps to interact with HIV-1 viral proteins, combined with their inherent adjuvant and immunogenic properties, indicates that hsps may serve as vehicles for antigen delivery and the design of vaccines against acquired immunodeficiency syndrome.
Stochastic behavior of cooling processes in hot nuclei (1997)

The collapse of structure effects observed in hot nuclei is interpreted in terms of a dynamic lattice model which describes the process of nucleon (clusters) evaporation from a hot nucleus, predicting the final mass distribution. Results are compared with experimental data for the ${}^{10}{\mathrm{B}+}^{9}\mathrm{Be}$ and ${}^{10}{\mathrm{B}+}^{10}\mathrm{B}$ reactions, and indicate that the structures observed in the low-energy mass distributions in both simulation and experiment are a consequence of the competition between the residual interactions and the thermalization dissipative process. As a characteristic feature of complex evolving systems, this competition leads to long term memory during the dissipative path, the observables becoming thus insensitive to the actual microscopic interactions.
A simplified technique to estimate the monostatic radar cross section of planar array antennas (2007)

The process of modeling and analyzing Radar Cross Section (RCS) can be very complex and very demanding concerning computational efforts. This paper presents a simplified technique to estimate the monostatic RCS of planar array antennas. It is used the APG-73 antenna to buildup and explain the model. The structural and the antenna RCS modes are computed separately. The calculation of the rim contribution (structural mode) is based on uniform asymptotic techniques formulated in terms of the Geometrical Theory of Diffraction (GTD). The antenna mode calculations consider the antenna radiation pattern and the feeders' characteristics. Results show that in most of the situation the edge diffraction is the foremost backscatter responsible. Some RCS reduction techniques are discussed as well. Finally, this simplified approach shows a good potentiality to allow a reasonable estimate of the behavior of the antenna RCS with low computational effort.
pH dependence of listeriolysin O aggregation and pore‐forming ability (2011)

Listeriolysin O (LLO) is the major factor implicated in the escape of Listeria monocytogenes from the phagolysosome. It is the only representative of cholesterol-dependent cytolysins that exhibits pH-dependent activity. Despite intense studies of LLO pH-dependence, this feature of the toxin still remains incompletely explained. Here we used fluorescence and CD spectroscopy to show that the structure of LLO is not detectably affected by pH at room temperature. We observed slightly altered haemolytic and permeabilizing activities at different pH values, which we relate to reduced binding of LLO to the lipid membranes. However, alkaline pH and elevated temperatures caused rapid denaturation of LLO. Aggregates of the toxin were able to bind Congo red and Thioflavin T dyes and were visible under transmission electron microscopy as large, amorphous, micrometer-sized assemblies. The aggregates had the biophysical properties of amyloid. Analytical ultracentrifugation indicated dimerization of the protein in acidic conditions, which protects the protein against premature denaturation in the phagolysosome, where toxin activity takes place. We therefore suggest that LLO spontaneously aggregates at the neutral pH found in the host cell cytosol and that this is a major mechanism of LLO inactivation.
Complete Genome Sequence of a Putative Densovirus of the Asian Citrus Psyllid, Diaphorina citri (2016)

Here, we report the complete genome sequence of a putative densovirus of the Asian citrus psyllid, Diaphorina citri Diaphorina citri densovirus (DcDNV) was originally identified through metagenomics, and here, we obtained the complete nucleotide sequence using PCR-based approaches. Phylogenetic analysis places DcDNV between viruses of the Ambidensovirus and Iteradensovirus genera.
A Canonical Expansion Model for Multivariate Media Exposure Distributions: A Generalization of the “Duplication of Viewing Law” (1991)

A multivariate media exposure model consisting of a truncated canonical expansion of the joint exposure probability is developed. The first term of the expansion is the product of the univariate marginal probabilities, resulting in a model that is a generalization of Goodhardt and Ehrenberg's “duplication of viewing law.” The proposed model is compared on the basis of estimation accuracy and computation speed with an accurate and quick “approximate” loglinear model and the popular Metheringham beta-binomial model. For large schedules the canonical expansion is more accurate than the approximate loglinear model but the reverse is true for small schedules. In addition, the proposed model is shown to be six times faster than the approximate loglinear model and much more accurate than Metheringham's model.
Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma (2012)

Two different therapeutic targets, EGFR-activating mutation and CT antigen, have a negative relationship with each other.
Temperature and Trinexapac‐Ethyl Effects on Bermudagrass Growth, Dormancy, and Freezing Tolerance (2002)

Applications of the plant growth regulator (PGR) trinexapac‐ethyl [4‐(cyclopropyl‐α‐hydroxymethylene)‐3,5‐dioxocyclohexane carboxylic acid ethylester] (TE) can delay winter dormancy in ‘Tifway’ bermudagrass ( Cynodon dactylon var. dactylon ), which suggests a response to TE when temperatures are suboptimum for bermudagrass growth. The purpose of this study was to investigate the interactive role of temperature and TE in bermudagrass growth responses, dormancy, and freezing tolerance. Trinexapac‐ethyl (0.11 kg a.i. ha −1 ) was applied in two growth chamber experiments, and across a 2‐yr period in the field. Results indicated that TE reduced vertical shoot growth and increased stolon production, turf density, and quality when applied at high temperatures (35–36°C). While TE effectively reduced vertical shoot growth at low (20–22°C) temperatures, little impact on stolon development was observed under these conditions. Autumn applications of TE when temperatures were cool (≈25°C) at the time of application led to decreased turfgrass density and quality. These responses may explain the effectiveness of using TE to aid in bermudagrass transition to overseeded cool‐season grasses and were probably due to the limited ability of bermudagrass to recover from initial post‐application growth reduction and observed leaf chlorosis. Observed delayed autumn dormancy due to summer applications of TE and accelerated dormancy due to late‐season applications did not conclusively relate to the freezing tolerance of bermudagrass.
SONTRAC: an imaging spectrometer for solar neutrons (2003)

An instrument capable of unambiguously determining the energy and direction of incident neutrons has important applications in solar physics-as well as environmental monitoring and medical/radiological sciences. The SONTRAC (SOlar Neutron TRACking) instrument is designed to operate in the neutron energy range of 20-250 MeV. The measurement principle is based on non-relativistic double scatter of neutrons off ambient protons (n-p scattering) within a block of densely packed scintillating fibers. Using this double-scatter mode it is possible to uniquely determine neutron energy and direction on an event-by-event basis. A fully operational science model of such an instrument has been built using 300 &mu;m (250 &mu;m active) scintillating fibers. The science model consists of a 5&times;5&times;5 cm cube of orthogonal plastic scintillating fiber layers. Two orthogonal imaging chains, employing image intensifiers and CCD cameras, allow full 3-dimensional reconstruction of scattered proton particle tracks. We report the results of the science model instrument calibration using 35-65 MeV protons. The proton calibration is the first step toward understanding the instrument response to n-p scatter events. Preliminary results give proton energy resolution of 2% (6%) at 67.5 (35) MeV, and angular resolution of 2&deg; (4.5&deg;) at 67.5 (35) MeV. These measurements are being used to validate detailed instrument simulations that will be used to optimize the instrument design and develop quantitative estimates of science return. Based on the proton calibration, neutron energy and angular resolution for a 10&times;10&times;10 cm version of SONTRAC is expected to be ~5% and <10&deg;, respectively, while the efficiency of the detector to double n-p scatter events is approximately 1%. We will also discuss ongoing opto-electronic developmental efforts and concepts for extending the instrument response to lower energies.
Copper–CNT interfacing with Cu-doped polydopamine in CNT carpet: copper nucleation and resistance decrease upon soft annealing (2021)

In recent years, Cu-CNT composites have attracted much attention due to their remarkable properties, in comparison to pure copper, such as higher ampacity and a lower thermal coefficient of resistance. However, the fabrication of an efficient Cu-CNT composite is still challenging, mainly due to the high cuprophobicity of CNTs. To strengthen the chemical interactions between Cu and CNTs, we propose using a Cu-doped polydopamine coating as an interface between CNTs and metallic copper. This work reports on the nucleation of copper particles on the surface of MWCNTs that are coated with Cu-doped polydopamine after annealing in an inert atmosphere at 573, 673 and 773 K. We show, for the first time to the best of our knowledge, that the polydopamine coating oxidizes during annealing and efficiently reduces Cu ions into metallic Cu. Interestingly, the sheet resistance of coated CNT carpets can be reduced by 33 and 37.6% after annealing at 573 and 773 K, respectively. Furthermore, the sheet resistance decrease does not depend on the size of copper particles (diameter ranging from 13 to 27 nm) or their surface density (from 2.27 × 10<sup>10</sup> to 5.7 × 10<sup>8</sup> particles per cm<sup>2</sup>). This sheet resistance drop is mainly attributed to the appearance of pyridinic nitrogen in the Cu-doped polydopamine structure after annealing at 673 K and above. Finally, we measure a negative temperature coefficient of resistance for all of the CNT carpets.
Weighted k-Means Algorithm Based Text Clustering (2009)

This paper proposes a weighted k-means clustering algorithm based on k-means (MacQueen, 1967; Anderberg, 1973) algorithm, and it can be used to cluster texts. Firstly, the weighted k-means algorithm changes the descriptive approach of text objects, and converts the categorical attributes to numeric ones to measure the dissimilarity of text objects by Euclidean distance; then, the weighted k-means algorithm uses weight vector to decrease the affects of irrelevant attributes and reflect the semantic information of text objects. Through an experiment, the weighted k-means algorithm is demonstrated to be more effective than k-means algorithm when used to cluster texts.
End-to-End Indoor Navigation Assistance for the Visually Impaired Using Monocular Camera (2018)

In this work a novel approach for the problem of indoor navigation assistance for the visually impaired people is proposed based solely on a monocular camera. In our formulation for the problem, we cast it as an image classification problem and tackle it holistically in an end-to-end fashion via state-of-the-art deep convolutional residual networks. Given an input RGB image of an indoor scene, our model can accurately guide the visually impaired people to navigate around the obstacles in the scene using four discrete navigational directions. Our model has achieved resilient results in terms of higher classification accuracies with a lower rate of false alarms. Moreover, we compared the performance of our model against two baseline approaches and it has outperformed them with more than 25% improvements with respect to the F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> measure evaluation score.
Modelling and Designing of Knitted Products Used in Compressive Therapy (2006)

The paper presents a procedure for designing compressive garments (CG) with a pre-set value of unit pressure exerted on the human body, such as are used in the compressive therapy of hypertropic scars (HS). The garment dimensions were determined in a free state, in dependence on the values of the body parts’ circumferences and the assumed value of unit pressure. The procedure is based on a developed dependency which considers the Laplace law, and on the garment’s mechanical characteristics in the form of a non-linear function of force vs. elongation. The procedure for designing compressive garments as elaborated was verified with the use of a special measuring stand designed to estimate the compression exerted by stocking products.
Toward Asymptotic Optimality: Sequential Unsupervised Regression of Density Ratio for Early Classification (2023)

Theoretically-inspired sequential density ratio estimation (SDRE) algorithms are proposed for the early classification of time series. Conventional SDRE algorithms can fail to estimate DRs precisely due to the internal overnormalization problem, which prevents the DR-based sequential algorithm, Sequential Probability Ratio Test (SPRT), from reaching its asymptotic Bayes optimality. Two novel SPRT-based algorithms, B2Bsqrt-TANDEM and TANDEMformer, are designed to avoid the overnormalization problem for precise unsupervised regression of SDRs. The two algorithms statistically significantly reduce DR estimation errors and classification errors on an artificial sequential Gaussian dataset and real datasets (SiW, UCF101, and HMDB51), respectively. The code is available at: https://github.com/Akinori-F-Ebihara/LLR_saturation_problem.
The electromagnetic field evolution in the presence of an ellipsoid shell. (2005)

Eddy current based sensors allow an accurate analysis of conductive materials structures. Electromagnetic field evolution in the presence of cylindrical, spherical and rectangular bodies is described using analytical methods [1], [2]. The present paper offers an insight into the interaction of a steady state electromagnetic field with an ellipsoid shell. The magnetic field evolution equations are formulated and their solutions are proposed using the method of separation of variables.
Remote sensing of ESD through optical and magnetic radiation fields (1999)

The optical radiation and the magnetic field generated by electrostatic discharges are measured, together with their current signatures. The observations show that during the initial growth, the temporal variation of the optical pulse is similar to that of the current. The two waveforms deviate from each other during the decaying part of the discharge, the optical signal having a longer duration. The peak current is linearly correlated with a correlation coefficient of 0.9, to the peak optical radiation. The measured currents were used to calculate the magnetic fields and a good agreement was observed between the measurements and calculations. The results show that both the optical radiation and the magnetic field can be used to sense remotely the currents in electrostatic discharges.
Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitro (1997)

A microtiter assay for drug evaluation has been developed with a strain of Toxoplasma gondii that expresses bacterial beta-galactosidase. By using chlorophenol red-beta-D-galactopyranoside (CPRG) as the substrate for beta-galactosidase, the efficacy of a drug against the parasite can be determined with a colorimetric readout. Drugs known to have activity against T. gondii (specifically, pyrimethamine, sulfadiazine, atovaquone, and clindamycin) were tested, and efficacies were determined by CPRG cleavage. The 50% inhibitory concentrations determined by the CPRG-based colorimetric assay were similar to those determined by the traditional radiolabelled uracil incorporation assay. Since CPRG is nontoxic to the parasite, viable drug-treated parasites can be obtained at the conclusion of the assay for further evaluation if desired. This assay provides a high-throughput and nonradioactive alternative for the identification of anti-T. gondii compounds.
Problems in the growth of Ce3+‐doped Li6Gd(BO3)3 crystals by Czochralski method (2008)

Abstract Cerium‐doped lithium gadolinium borate (Li 6 Gd(BO 3 ) 3 :Ce) single crystal has been grown by the Czochralski method. Some problems like macro defects and concave growth face were found. The macro defects are suggested to be caused by constitutional supercooling and concave growth face is caused by interface inversion. These problems can be resolved or eliminated through controlling the growth parameters strictly. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Carbostyril Derivatives as Antenna Molecules for Luminescent Lanthanide Chelates (2004)

Luminescent lanthanide complexes consisting of a lanthanide-binding chelate and organic-based antenna molecule have unusual emission properties, including millisecond excited state lifetimes and sharply spiked spectra, compared to standard organic fluorophores. We have previously used carbostyril (cs124, 7-amino-4-methyl-2(1H)-quinolinone) as an antenna molecule (Li and Selvin, J. Am. Chem. Soc., 1995) attached to a polyaminocarboxylate chelate such as DTPA. Here, we report the chelate syntheses of DTPA conjugated with cs124 derivatives substituted on the 1-, 3-, 4-, 5-, 6-, and 8-position. Among them, the DTPA chelate of cs124-6-SO(3)H has similar lifetime and brightness for both Tb(3+) and Eu(3+) compared to the corresponding DTPA-cs124 complexes, yet it is significantly more soluble in water. The Tb(3+) complex of DTPA-cs124-8-CH(3) has significantly longer lifetime compared to DTPA-cs124 (1.74 vs 1.5 ms), indicating higher lanthanide quantum yield resulting from the elimination of back emission energy transfer from Tb(3+) to the antenna molecule. Thiol-reactive forms of chelates were made for coupling to proteins. These lanthanide complexes are anticipated to be useful in a variety of fluorescence-based bioassays.
Design and development of pilus vaccines for Haemophilus influenzae diseases (1989)

BRINTON, CHARLES C. JR. PHD; CARTER, MELINDA J. BS; DERBER, DAN B. BS; KAR, SIDDHARTHA PHD; KRAMARIK, JEAN A. MS; -C. TO, AGNES C. MS; -M. TO, SAM C. PHD; WOOD, SARAH W. SCD Author Information
L'origine des indicateurs de style dans les dictionnaires français (2002)

Cet article prend un point de vue diachronique sur les dictionnaires afin de saisir les changements d'attitude vis-a-vis du langage. En effet, a travers l'examen de l'utilisation des indicateurs de style dans les dictionnaires depuis le XVe siecle, l'A. veut montrer l'evolution des attitudes envers les registres (familier, populaire...). Il recense la terminologie utilisee pour le francais familier dans les dictionnaires, de l'origine des indicateurs de style jusqu'a nos jours, ou l'on observe une multiplication des ouvrages consacres a l'argot ou au verlan
ACOUSTICS2008/1442 Viscosimetry using a new electromagnetic-acoustic microbalance (2008)

The nanostructure evolution of gels, biomaterials or porous media can be characterized by its mechanical properties. Few non-destructive techniques are developed to investigate the viscosity evolution. This paper present a new electromagnetic-acoustic technique using a wireless thickness shear mode transducer. A suitable model of the measurement is also presented to characterize the viscosity of the nanostructure in contact with the transducer. This transducer is a double copper-clad PVDF substrate resonator, designed to operate over a wide radiofrequency range without lumped tuning capacitors. This architecture constitutes an alternative solution to design a high-Q ultrasonic microbalance. To characterize the material at the surface of the transducer, the evolution of the induced complex impedance is measured. From this evolution, the mechanical energy storage and dissipation in the material can be extracted. In order to validate the lumped element model used, a series of glycerol/water mixtures is studied. We show that the resonant frequency shift and damping follow an accurate linear shape (<5%) according to the square root of the liquid viscosity and density product. This result is in good agreement with the classical prediction of Martin and Kanazawa obtained with a quartz crystal microbalance.
Supplementary materials and methods from On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid Tumors (2023)

&lt;p&gt;Shows supplementary methods&lt;/p&gt;
A new gas chromatography/tandem mass spectrometry method for analysis of monoaromatic steroids in petroleum (1990)

Abstract A new gas chromatography/tandem mass spectrometry (GC/MS/MS) analytical approach for monoaromatic steroids is described in comparison with a more conventional GC/MS analysis. Some examples are reported both on standards and on real samples.
The Chemistry of the Benzylpyridines. I. 2-(4-Acetylbenzyl)- and 4-(4-Acetylbenzyl)-pyridines1 (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of the Benzylpyridines. I. 2-(4-Acetylbenzyl)- and 4-(4-Acetylbenzyl)-pyridines1Frank J. Villani and Domenick PapaCite this: J. Am. Chem. Soc. 1950, 72, 6, 2722–2723Publication Date (Print):June 1, 1950Publication History Published online1 May 2002Published inissue 1 June 1950https://pubs.acs.org/doi/10.1021/ja01162a102https://doi.org/10.1021/ja01162a102research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts