gebhart/patrepeval huggingface dataset:
MODELING FOR OPTIMIZATION OF BIOCHEMICAL PROCESSES INVOLVING PRODUCTION AND RECOVERY OF INCLUSION-BODIES (1993)

In this paper we present a model for the simulation of one class of biochemical processes involving recombinant micro-organisms in which the product forms as a solid inclusion body inside each cell. Recovery of the product is achieved by disruption of the micro-organism followed by collection by centrifugation and microfiltration. The operation of each unit strongly affects those downstream and simulation can be used to investigate these interactions and develop strategies for optimal recovery of valuable product. Since the recovery processes are based on particle size the key modelling issue for optimisation is inclusion body particle size distribution in the fermentation stage.
Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice (2009)

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1alpha (HIF-1alpha) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1alpha proteins expression, thereby providing a benefit in therapy of cerebral ischemia.
Free Energy Landscape of the Retinol/Serum Retinol Binding Protein Complex: A Biological Host−Guest System (2010)

Small molecule host-guest complexes have traditionally provided model systems for biological ligand recognition. Nonetheless, direct extrapolation of these results is precluded by the comparative simplicity of these supramolecular assemblies. If energetic behavior analogous to small molecule host-guest chemistry exists, it is unclear how this would manifest for protein-small molecule interactions. To answer this question, we employ the retinol/serum retinol binding protein (sRBP) system as an analogue of a classical host-guest complex. Using a combination of molecular dynamics simulations and free energy methods, we decompose the potential of mean force for retinol unbinding from the sRBP into constituent interactions. Our calculations reveal an unexpected mechanism of host-guest complexation. Desolvation is sufficient to drive formation of an intermediate binding state; however, a combination of electrostatic and van der Waals interactions pull the intermediate into a stable configuration. Association is accompanied by a change in the conformational flexibility of the portal domains of sRBP and subsequent "stiffening" of the holo sRBP, reflecting an "order-disorder" transition in the protein.
Big data dimensional analysis (2014)

The ability to collect and analyze large amounts of data is a growing problem within the scientific community. The growing gap between data and users calls for innovative tools that address the challenges faced by big data volume, velocity and variety. One of the main challenges associated with big data variety is automatically understanding the underlying structures and patterns of the data. Such an understanding is required as a pre-requisite to the application of advanced analytics to the data. Further, big data sets often contain anomalies and errors that are difficult to know a priori. Current approaches to understanding data structure are drawn from the traditional database ontology design. These approaches are effective, but often require too much human involvement to be effective for the volume, velocity and variety of data encountered by big data systems. Dimensional Data Analysis (DDA) is a proposed technique that allows big data analysts to quickly understand the overall structure of a big dataset, determine anomalies. DDA exploits structures that exist in a wide class of data to quickly determine the nature of the data and its statical anomalies. DDA leverages existing schemas that are employed in big data databases today. This paper presents DDA, applies it to a number of data sets, and measures its performance. The overhead of DDA is low and can be applied to existing big data systems without greatly impacting their computing requirements.
Inertial Navigation Systems with Three Single Axis Gyros and a Physical Pendulum (1960)

SYSTEM1.1 Vertical indication with a physical pend_ulum 1.11 rhe equations of notion of a single axis pend-ulun moving at constant height in a spherical_ field-L.L2 The Schul_er-tuning cond-ition L.L1 An estimate of the errors clue to variations in height L.14 The impossibility of r.echanizing a Schuler-tuned.pend-ulum L.2 vertical ind-ication with a physical pend-ul-um and-an inertial reference SOME POssrBlE I/,,IAYS 0F L{EcHit}Trzi}TG THE NAVTGATTON sysrEM 2.L Introd-uction 2.2 Description of a system of bype 1 2.1 lescription of a system of type 2 A SII/IPLIFIED .}AIYSIS OF THE SII{GLE AXIS SYSTEMS 3.I Iniroduction 1" 2 A:ralysis of a single-axis sys';em of type 1 1.2IA short descr-ptio 5.22 The Schufer-tuning condition 1.21The ecluations of the system and_ the block-d_j_agram 1.24 How to obtaln position information 1.25 The equations f or the na-.rg:at j_on eror J 4 4. J.3 Analysis of a single-axis system of type z ) ,jf A short c1e sci.iption 3.J2 The Schliler-tuning cond.itiont't1 sone r,''iays of nechanizing the schuler-tuning condit:-on, Ver.blca indication in the An_ schtz Gyro Conpass 1 .14The ecluations of thc sys tem a.nd the block-di agTm 1.35 Hov to cbain position information z where Hp
Light Chain Multiple Myeloma: High Serum Free Light Chain Concentrations Portend Renal Damage and Poorer Survival (2021)

As noted for light chain predominant multiple myeloma, high serum free light chain concentration in light chain multiple myelomas are associated with higher renal disease burden and shorter survival. Monitoring of serum free light chain concentrations and customizing treatments to address this parameter are warranted.
LAPAROSCOPIC HERNIORRHAPHY (1991)

Laparoscopic herniorrhaphy is compared with conventional herniorrhaphy in 20 patients, who underwent laparoscopic herniorrhaphy utilizing a Mersilene plug and patch graft, and high ligation of the neck of the sac with an Endo-GIA. Patients were pain-free and returned to normal activity the first postoperative day. There was one recurrent direct inguinal hernia in an indirect repair. Laparoscopic herniorrhaphy appears to be a safe, effective way to repair indirect inguinal hernias and certain direct inguinal hernias. There is a marked reduction of pain and rapid return to normal activity. The disadvantage of this procedure is the lack of long-term follow-up.
Improved Maturity and Ripeness Classifications of Magnifera Indica cv. Harumanis Mangoes through Sensor Fusion of an Electronic Nose and Acoustic Sensor (2012)

In recent years, there have been a number of reported studies on the use of non-destructive techniques to evaluate and determine mango maturity and ripeness levels. However, most of these reported works were conducted using single-modality sensing systems, either using an electronic nose, acoustics or other non-destructive measurements. This paper presents the work on the classification of mangoes (Magnifera Indica cv. Harumanis) maturity and ripeness levels using fusion of the data of an electronic nose and an acoustic sensor. Three groups of samples each from two different harvesting times (week 7 and week 8) were evaluated by the e-nose and then followed by the acoustic sensor. Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) were able to discriminate the mango harvested at week 7 and week 8 based solely on the aroma and volatile gases released from the mangoes. However, when six different groups of different maturity and ripeness levels were combined in one classification analysis, both PCA and LDA were unable to discriminate the age difference of the Harumanis mangoes. Instead of six different groups, only four were observed using the LDA, while PCA showed only two distinct groups. By applying a low level data fusion technique on the e-nose and acoustic data, the classification for maturity and ripeness levels using LDA was improved. However, no significant improvement was observed using PCA with data fusion technique. Further work using a hybrid LDA-Competitive Learning Neural Network was performed to validate the fusion technique and classify the samples. It was found that the LDA-CLNN was also improved significantly when data fusion was applied.
English Generation from a Knowledge Base and Overly General Classes (2015)

In this paper, we describe the range of sentences that we synthesize from a knowledge base (KB) using a natural language generation (NLG) system. We give an overview of our NLG system, and then focus on the specific challenge in handling overly general classes such as Tangible-Entity and Physical-Object. Such classes are unavoidable in the KB, and it is undesirable to show them in an output for end users. Our approach has been implemented in an intelligent textbook application that helps students learn better.
A Phase-Variable Surface Layer from the Human Gut Commensal Bacteroides (2014)

While some microbial encounters can be pathogenic, most interactions between humans and microorganisms do not result in disease. Our gastrointestinal tract harbors approximately 100 trillion organisms, spanning about 1000 species that live in harmony with us. While we provide them with food and shelter, this complex intestinal bacterial community supplies essential nutrients, metabolizes indigestible compounds, protects us from pathogenic organisms and helps develop our immune system, thereby establishing a symbiotic relationship. Bacteroides are one of the most abundant bacterial genera living in the human gut and has long been a model system for studying the molecular mechanisms of commensal-host interactions. In the course of searching for surface structures that have immunomodulatory properties on the host, we serendipitously discovered a previously unknown surface protein BT1927 from Bacteroides that is capable of completely covering the surface of the bacteria by creating a tessellated surface layer. Interestingly, the formation of the entire proteinaceous capsule is controlled by inversion of a single promoter, making it phase-variable. Although only ~ 0.1% of the population produce this capsule in laboratory culture, analyzing the fecal metagenome sequence data from the Human Microbiome Project revealed that ~ 8% of the population produce a homologous capsule in humans, suggesting its significance in vivo. From a series of functional studies, we found that the BT1927-expressing subpopulation is profoundly resistant to complement-mediated killing, due in part to the BT1927-mediated blockade of C3b deposition. Our results show that the Bacteroides capsule is capable of a far greater degree of structural variation than previously known, perhaps to cope with the varying environmental conditions in the human intestine.
A Study of Detachment of Model Coarse Particles from Bubbles Using a Novel Electro-Acoustic Technique (2009)

In this paper, a detachment of particles from bubbles was investigated using a novel electro-acoustic technique. The experimental setup consisted of a loudspeaker connected to a computer through an amplifier. A teflon capillary tube was attached to the membrane of a loudspeaker. A bubble-particle aggregate on the other end of the capillary tube was subjected to vibration when the sinusoidal signal of fixed frequency and amplitude generated by the computer was transmitted to the loudspeaker. The critical amplitude of particle detachment was determined at a fixed frequency (50 Hz). The detachment experiments were conducted using model quartz particles of various size and hydrophobicity. Results showed that particles (600-850 m) with high contact angle (90 degree) required high amplitudes for detachment from bubbles. In contrast, quartz particles with low contact angle (49 degree) exhibited the considerably lower critical detachment amplitude. The critical detachment amplitude was related to the stability of bubble-particle aggregates. The results of electro-acoustic experiments correlated well with the outcomes of corresponding bench flotation tests.
Cobaloximes(II) and vitamin B12r as oxygen carriers. Evidence for monomeric and dimeric peroxides and superoxides (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCobaloximes(II) and vitamin B12r as oxygen carriers. Evidence for monomeric and dimeric peroxides and superoxidesGerhard N. Schrauzer and Lian Pin LeeCite this: J. Am. Chem. Soc. 1970, 92, 6, 1551–1557Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ja00709a020https://doi.org/10.1021/ja00709a020research-articleACS PublicationsRequest reuse permissionsArticle Views579Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplemental figure 2 from MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation (2023)

&lt;p&gt;Figure - Fig S2. Combined treatment with NPS-1034 and erlotinib&lt;/p&gt;
Design of Long Persistent White Phosphorescence in a Composite Phosphor Via Energy Transfer Mechanism (2015)

A high quality composite phosphor powder of warm to cool white emission and long afterglow phosphorescence was reported by the process of energy transfer in a composite phosphor. The composite phosphor particles include at least two types of phosphor particles viz. a blue white persistent component and yellow fluorescent component. The blue white extremely long persistent component transfers its afterglow to the yellow fluorescent component in the composite phosphor followed by the color mixing process to generate the white afterglow. The composite phosphor is designed in such a way that the excitation spectrum of the fluorescent component was overlapped as much with the afterglow emission of the persistent component. The composite phosphor emission spectrum can be well tuned from warm to cool white depending on the proportions of the composite phosphors and energy transfer extent. Phosphor includes powders, ceramics and resin composites.
Hybrid Analog–Digital Precoding Design for Secrecy mmWave MISO-OFDM Systems (2017)

Millimeter-wave large-scale antenna systems typically apply hybrid analog-digital precoders to reduce hardware complexity and power consumption. In this paper, we design hybrid precoders for physical-layer security under two types of channel knowledge. With full channel knowledge at transmitter, we provide sufficient conditions on the minimum number of RF chains needed to realize the performance of the fully digital precoding. Then, we design the hybrid precoder to maximize the secrecy rate. By maximizing the average projection between the fully digital precoder and the hybrid precoder, we propose a low-complexity closed-form hybrid precoder. We extend the conventional projected maximum ratio transmission scheme to realize the hybrid precoder. Moreover, we propose an iterative hybrid precoder design to maximize the secrecy rate. With partial channel knowledge at transmitter, we derive a secrecy outage probability upper-bound. The secrecy throughput maximization is converted into a sequence of secrecy outage probability minimization problems. Then, the hybrid precoder is designed to minimize the secrecy outage probability by an iterative hybrid precoder design. Performance results show the proposed hybrid precoders achieve performance close to that of the fully digital precoding at low and moderate signal-to-noise ratios (SNRs), and sometimes at high SNRs depending on the system parameters.
Propagation of infrared light in flexible hollow waveguides (1976)

Designs are described for flexible hollow waveguides with low ir loss over distances on the order of 1 m. Transmission losses at 10.6 microm are calculated, and the effect of bends and twists is discussed. A hollow combination metal-dielectric-walled rectangular waveguide is proposed that can have transmission as high as 95% for a 1-m length, while bent with a 1-m radius of curvature.
Supplementary Methods and Figure Legends from Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Revised Supplementary Methods and Legends&lt;/p&gt;
Genome Sequence of the Probiotic Bacterium Sporolactobacillus vineae SL153 T (2012)

The novel Sporolactobacillus vineae SL153(T) strain has excellent intestinal adherence and growth inhibitory effect on pathogenic microorganisms, including Vibrio genus microorganisms, and therefore can be effectively used for the prevention and treatment of disease caused by pathogenic microorganisms. Here, we first report the draft genome sequence of a novel species in the genus Sporolactobacillus.
Evaluation of a new cefepime-clavulanate ESBL Etest to detect extended-spectrum -lactamases in an Enterobacteriaceae strain collection (2004)

The new Etest ESBL strip containing cefepime-clavulanate is a valuable supplement to current methods for detection of ESBLs. In our study collection, the cefepime-clavulanate strip was the best configuration for detection of ESBLs, particularly in Enterobacter spp.
The Last Word (1988)

See also: The Finishing Touches in Nipple-Areolar ReconstructionSemin Plast Surg 1988; 2(01): 1-17DOI: 10.1055/s-2008-1080506
Effects of imbalanced modulation in continuous-variable quantum key distribution (2023)

We experimentally investigate the impact of non-optimal state preparation on a Gaussian-modulated coherent state CVQKD system. We show that modulation with imbalanced strength in the amplitude and phase quadratures reduces the optimal key rate over certain distance.
Analysis of force-deconvolution methods in frequency-modulation atomic force microscopy (2012)

In frequency-modulation atomic force microscopy the direct observable is the frequency shift of an oscillating cantilever in a force field. This frequency shift is not a direct measure of the actual force, and thus, to obtain the force, deconvolution methods are necessary. Two prominent methods proposed by Sader and Jarvis (Sader-Jarvis method) and Giessibl (matrix method) are investigated with respect to the deconvolution quality. Both methods show a nontrivial dependence of the deconvolution quality on the oscillation amplitude. The matrix method exhibits spikelike features originating from a numerical artifact. By interpolation of the data, the spikelike features can be circumvented. The Sader-Jarvis method has a continuous amplitude dependence showing two minima and one maximum, which is an inherent property of the deconvolution algorithm. The optimal deconvolution depends on the ratio of the amplitude and the characteristic decay length of the force for the Sader-Jarvis method. However, the matrix method generally provides the higher deconvolution quality.
Mechanical control of tissue-engineered bone (2013)

Bone is a load-bearing tissue and physical forces play key roles in the development and maintenance of its structure. Mechanical cues can stimulate the expression of an osteogenic phenotype, enhance matrix and mineral deposition, and influence tissue organization to improve the functional outcome of engineered bone grafts. In recent years, a number of studies have investigated the effects of biophysical forces on the bone formation properties of osteoprogenitor cells. The application of physiologically relevant stimuli to tissue-engineered bone may be determined through observation and understanding of forces to which osteoblasts, osteoclasts, and osteocytes are exposed in native bone. Subsequently, these cues may be parameterized and their effects studied in well-defined in vitro systems. The osteo-inductive effects of three specific mechanical cues - shear stress, substrate rigidity, and nanotopography - on cells cultured in monolayer or in three-dimensional biomaterial scaffolds in vitro are reviewed. Additionally, we address the time-dependent effects of mechanical cues on vascular infiltration and de novo bone formation in acellular scaffolds implanted into load-bearing sites in vivo. Recent studies employing cutting-edge advances in biomaterial fabrication and bioreactor design have provided key insights into the role of mechanical cues on cellular fate and tissue properties of engineered bone grafts. By providing mechanistic understanding, future studies may go beyond empirical approaches to rational design of engineering systems to control tissue development.
An example of automatically troubleshooting a throughput bottleneck using model based techniques (2003)

A detailed example is given for the process of troubleshooting a throughput bottleneck, and the techniques used by human analysts are contrasted with those used by an automated tool called ANT (automatic network troubleshooter). Troubleshooting a throughput bottleneck involves finding specific parameters out of hundreds of possible parameters that can be tuned to increase throughput. The automated tool uses an expert system to speed the search by reducing the complexity of a performance model. Sensitivity analysis is done on the simplified model to identify parameters that can be changed to increase throughput. The output of the tool is a simple model of the bottleneck process and a list of parameters that can be tuned. ANT uses shallow reasoning expert systems to give hints about possible locations for the bottleneck, but backs the suspicions with deep reasoning about the underlying mechanisms used by the network. A prototype tool demonstrates that combining performance modeling with expert systems allows for faster and more accurate troubleshooting that can be done by a human analysis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>