gebhart/patrepeval huggingface dataset:
ARGYROPHILIC NUCLEOLAR ORGANIZER REGION IN PROLIFERATING CELL HAS A PREDICTIVE VALUE FOR LOCAL RECURRENCE IN SUPERFICIAL BLADDER TUMOR (1999)

Proliferating cell NOR had a predictive value for local recurrence in patients with superficial bladder tumor.
Comparison of Collapsibility of the Human Upper Airway During Anesthesia and During Sleep (2019)

These results demonstrate that the magnitude of upper airway collapsibility during anesthesia and sleep is directly related. However, the upper airway is systematically more collapsible during anesthesia than sleep, suggesting greater vulnerability to upper airway obstruction in the anesthetized state.
Nutritional assessment and preliminary report on early support of the trauma patient. (1983)

The high nitrogen demands imposed by severe trauma may quickly render the injured patient malnourished. Nutritional assessment of these patients is confused by tissue damage, shock, blood loss, operation, and anesthesia. Consequently, standard nutritional markers do not correlate well with immunocompetence and postoperative morbidity. For this reason we devised an abdominal trauma index (ATI) based on the anatomical severity of injury. The ATI is calculated by assigning a risk factor (1-5) to each organ injured and then multiplying this by a severity-of-injury estimate (1-5). The sum of the individual organ scores comprises the final ATI. The incidence of postlaparotomy complications is low (5%) with an ATI less than 15, intermediate (15%) with 15-25, and high (50%) with greater than 25. Having identified the high-risk trauma patient, we initiated a prospective randomized study to assess the cost-benefit of early nutritional support. Patients with an ATI greater than 15 were allocated to a control group (no supplemental nutrition during first five postoperative days) or enteral-fed group. The enteral group had a needle catheter jejunostomy (NCJ) placed at laparotomy. The constant infusion of an elemental diet (Vivonex HN) was begun at 18 hours postoperatively and advanced to 3,000 cc/day within 72 hours. To date 26 patients (14 control, 12 enteral) have been entered in this study. At one week, nitrogen balance in the control group (-12.9 to -11.1 g/day) continues to be negative compared to a positive trend (-12.2 to +3.3 g/day) in the fed group. In control patients serum albumin (3.54 +/- 0.16 to 3.19 +/- 0.15 g%) and transferrin (227 +/- 11 to 204 +/- 10 mg%) decrease while in the enteral patients albumin (3.27 +/- 0.11 to 3.34 +/- 0.15 g%) and transferrin (229 +/- 10 to 234 +/- 12 mg%) remain stable. Although the incidence of overall morbidity is similar, septic complications occurred in 29% (4/14) of the control group compared to none in the enteral group. Our experience suggests the following: (1) Anatomical severity of injury is a better predictor of postinjury septic morbidity than standard nutritional markers; (2) immediate postoperative feeding by NCJ is safe and feasible; and (3) early nutritional support decreases the incidence of septic complications in the severely injured patient.
Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis (2005)

Runt-related transcription factor 3 belongs to the runt domain family of transcription factors that play a pivotal role during normal tissue development and tumorigenesis in several organs. We directed our attention to the expression of RUNX3 protein in human lung AC and non-neoplastic lung tissues, comparing the results with clinicopathological profiles. We evaluated the expression of RUNX3 protein in 17 pairs of lung AC and non-neoplastic lung tissue. Furthermore, 98 lung AC were studied to examine the frequency of RUNX3-positive cells. Western blot analysis showed a single band at 45 kDa in all 17 AC and non-neoplastic tissues. Immunohistochemistry revealed immunoreactivity in alveolar type II pneumocytes or Clara cells. RUNX3 was expressed more frequently in the carcinomas with a BAC component than in those without (P < 0.01). Lower RUNX3 levels were associated with poorly differentiated types (P = 0.049). The five-year survival rate was significantly higher in the 50 patients with higher levels of RUNX3 expression than in the 48 patients with lower levels (P = 0.027). The expression of RUNX3 protein in lung AC might play a pivotal role in tumor progression and patients' survival.
Identification of Tula hantavirus in Pitymys subterraneus captured in the Cacak region of Serbia-Yugoslavia (2002)

The data demonstrate that Pitymys subterraneus also serves as a rodent reservoir of Tula virus in Serbia-Yugoslavia. To what extent this represents virus spillover from Microtus arvalis warrants further investigation.
Increasing potency and safety of anticancer drugs through sortilin receptor-mediated cancer therapy: A new targeted approach for the treatment of ovarian cancer. (2019)

e17068 Background: The development of personalized therapies against ovarian cancer remains highly challenging in current modern oncology. One strategy to achieve greater selectivity and better anticancer drug delivery into cancer cells is to conjugate cytotoxic agents to specific peptide ligands that selectively target receptors abundantly and/or exclusively expressed on these cells. Increased expression of Sortilin, a scavenging receptor, has been clinically observed in invasive ovarian cancer biopsies, and correlated with tumor grades. In light of this, we developed a peptide conjugation platform and a new Sortilin receptor-mediated vectorization strategy to increase cell targeting selectivity and cell delivery efficacy of anticancer agents. Methods: As a proof-of-concept, Doxorubicin was conjugated to a Sortilin binding peptide (KA-peptide). In vitro, intracellular delivery of the Doxorubicin-KA-peptide conjugate (DoxKA) was assessed in ES-2 and SKOV-3 ovarian cancer cell line models using flow cytometry and fluorescent microscopy. Sortilin gene silencing was performed with specific siRNA. DoxKA efficacy and safety were evaluated in vivo using ES-2 (CD1 nude mice) and SKOV-3 (athymic mice) subcutaneous xenograft models. Results: Uptake of DoxKA was observed in both Sortilin-positive ovarian cancer cell lines tested and was reduced when Sortilin expression was specifically silenced or upon competition with the Sortilin ligands Neurotensin and Progranulin. Results indicate that the uptake of DoxKA occurs via Sortilin-mediated endocytosis in contrast to simple diffusion for Doxorubicin. DoxKA was found to bypass the P-glycoprotein (P-gp) efflux pump in MDCK-MDR1 cells overexpressing P-gp as the uptake of DoxKA was unaffected by the P-gp inhibitor Cyclosporin A. In vivo, DoxKA showed lower potential side effects than Doxorubicin alone did, with decreased accumulation in healthy tissues such as heart and ovary. DoxKA caused a more potent inhibition of human ovarian tumor xenografts growth in mice and was better tolerated (absence of leukopenia and neutropenia) than the unconjugated Doxorubicin at an equivalent dose. Conclusions: These results strongly support the future clinical use of this platform to generate novel personalized therapeutics with specific targeting of Sortilin-positive tumors in the next stage of development in phase 1 clinical trial.
Advanced multi-objective and surrogate-assisted optimization of topologically diverse metasurface architectures (2018)

Advancements in micro-and nano-fabrication techniques are enabling the realization of high-performance metasurfaces which exploit the generalized Snell’s law of refraction to achieve disruptive optical functionalities. Moreover, metasurfaces can be used in conjunction with conventional optical elements to achieve massive size, weight, and power (SWaP) reduction. However, no commercial tools exist which can efficiently model optical systems whose geometrical features span many orders-of-magnitude in spatial scale. Therefore, new forward solvers must be developed in order to make such multiscale problems tractable. Furthermore, optimization of multiscale optical systems is crucially-important in order to maximize system performance and minimize SWaP. While how one achieves a specific set of desired performances with conventional optical elements is generally well understood and thoroughly presented in design textbooks, it is not always clear how to design a nanoscale optical device to best achieve a desired set of performances. Therefore, a small subset of well-understood and/or canonical structures such as split-ring resonators are typically employed to achieve the targeted functionality. However, relaxing the device’s topological constraints may lead to improved performance albeit at the expense of a larger solution space to explore. To mitigate this issue, we employ custom state-of-the art multi-objective and surrogate-assisted optimization algorithms to explore the solution space afforded by emerging manufacturing techniques in order to design metasurface topologies that achieve an arbitrary number of user-specified performance criteria.
Modal dispersion in multimode graded-index fibers (1975)

A complete analysis of the propagation characteristics of a ray through an axially symmetric graded-index medium is carried out in the geometrical optics approximation. First, two constants of the motion are shown to exist for a ray propagating in an infinite medium. Secondly, these constants of the motion are shown to be invariant when reflection occurs on the core-cladding interface of cladded graded index fibers. This conservation law allows the study of the propagation characteristics of a ray through a fiber even though its trajectory may be discontinuous because of reflection at the core-cladding interface. The temporal behavior of various cladded parabolic-index fibers is given by their impulse responses when excited uniformly by parallel beams under different input angles. Rays are shown to propagate in two different ways: a reflected type of propagation takes place through reflections on the core-cladding interface, and a selfocusing type of propagation where rays go through the fiber core without touching the cladding.
Extended cyclic fatigue life of F2 ProTaper instruments used in reciprocating movement (2010)

Movement kinematics is amongst the factors determining the resistance of rotary NiTi instruments to cyclic fracture. Moreover, the reciprocating movement promoted an extended cyclic fatigue life of the F2 ProTaper instrument in comparison with conventional rotation.
Chemical Aspects of Actinomycete Metabolites as Contributors of Taste and Odor (1963)

This article discusses an episode of mustiness that was extremely resistant to treatment processes, which occurred on the Cedar River in Iowa during June through July, 1961. A study was done on the chemical characteristics of the metabolic products of actinomycetes isolated and cultured from the Cedar River during the 1961 period of musty taste. The difficulty of analysis, effect of cultural conditions, isolation procedures and actinomycete‐produced substances are all discussed, along with neutral‐fraction characteristics, further purification, constituents of eluate, and infrared analysis. An illustration of the similarity between organic materials of river water and extracted actinomycete metabolites is provided in a comparison of the infrared spectra of an extract of musty Cedar River water, and an extract of the laboratory‐cultured actinomycetes.
A SULPHLEX MIXTURE DESIGN METHOD BASED ON THE INDIRECT TENSILE TEST (1983)

A method of designing Sulphlex mixtures was developed based on the indirect tension test. The design procedure allows prediction of paving mix performance from the ultimate tensile properties. These properties were found to be sensitive to binder content variation. The toughness of Sulphlex and asphalt concrete mixes was shown to reach a well-defined peak, which corresponds very closely to the optimum binder content. The vaiation of toughness with changes in aggregate angularity, temperature, and rate of loading was examined. A more detailed analysis of mixture performance was based on the failure envelope. The concept of a window on the failure stress-strain plot formed by boundary curves representing types of pavement distress was developed. Boundary curves were established for the permanent deforamtion and thermal cracking modes of failure. A method of estimating the fatigue life of paving mixture was based on the relationship between resilient modulus and temperature using the conventional approach of analyzing fatigue data. The procedure for optimizing a mixture design was outlined, and an example is included.
METAL-CATALYZED ROUTES TO RINGS, CHAINS, AND MACROMOLECULES BASED ON INORGANIC ELEMENTS (2004)

In this perspective article, some of our recent work directed at the development of new catalytic routes to rings, chains, and macromolecules based on main group and transi- tion elements will be discussed.
Prediagnostic Plasma Vitamin D Metabolites and Mortality among Patients with Prostate Cancer (2011)

Although potential bias of less advanced disease due to more screening activity among men with high 25(OH)D levels cannot be ruled out, higher prediagnostic plasma 25(OH)D might be associated with improved prostate cancer prognosis.
Search result re-ranking by feedback control adjustment for time-sensitive query (2009)

We propose a new method to rank a special category of time-sensitive queries that are year qualified. The method adjusts the retrieval scores of a base ranking function according to time-stamps of web documents so that the freshest documents are ranked higher. Our method, which is based on feedback control theory, uses ranking errors to adjust the search engine behavior. For this purpose, we use a simple but effective method to extract year qualified queries by mining query logs and a time-stamp recognition method that considers titles and urls of web documents. Our method was tested on a commercial search engine. The experiments show that our approach can significantly improve relevance ranking for year qualified queries even if all the existing methods for comparison failed.
Noonan Syndrome in South Africa: Clinical and Molecular Profiles (2019)

Noonan Syndrome (NS) is a common autosomal dominant multisystem disorder, caused by mutations in more than 10 genes in the Ras/MAPK signaling pathway. Differential mutation frequencies are observed across populations. Clinical expressions of NS are highly variable and include short stature, distinctive craniofacial dysmorphism, cardiovascular abnormalities, and developmental delay. Little is known about phenotypic specificities and molecular characteristics of NS in Africa. The present study has investigated patients with NS in Cape Town (South Africa). Clinical features were carefully documented in a total of 26 patients. Targeted Next-Generation Sequencing (NGS) was performed on 16 unrelated probands, using a multigene panel comprising 14 genes: <i>PTPN11, SOS1, RIT1, A2ML1, BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SHOC2</i>, and <i>SPRED1</i>. The median age at diagnosis was 4.5 years (range: 1 month-51 years). Individuals of mixed-race ancestry were most represented (53.8%), followed by black Africans (30.8%). Our cohort revealed a lower frequency of pulmonary valve stenosis (34.6%) and a less severe developmental milestones phenotype. Molecular analysis found variants predicted to be pathogenic in 5 / 16 cases (31.2%). Among these mutations, two were previously reported: <i>MAP2K1</i>-c.389A>G (p.Tyr130Cys) and <i>PTPN11</i> - c.1510A>G (p.Met504Val); three are novel: <i>CBL</i>-c.2520T>G (p.Cys840Trp), <i>PTPN11</i>- c.1496C>T (p.Ser499Phe), and <i>MAP2K1</i>- c.200A>C (p.Asp67Ala). Molecular dynamic simulations indicated that novel variants identified impact the stability and flexibility of their corresponding proteins. Genotype-phenotype correlations showed that clinical features of NS were more typical in patients with variants in <i>MAP2K1</i>. This first application of targeted NGS for the molecular diagnosis of NS in South Africans suggests that, while there is no major phenotypic difference compared to other populations, the distribution of genetic variants in NS in South Africans may be different.
A Folded Contactless Waveguide Flange for Low Passive-Intermodulation Applications (2018)

Contact nonlinearity is one of the primary sources of passive intermodulation (PIM). Common methods to eliminate the contact nonlinearity are focused on improving the electrical contact. In this letter, the contactless waveguide flange (CWF) based on gap waveguide technology is first applied to solve the PIM problem caused by waveguide connection. A compact folded CWF is proposed for low-frequency applications. The artificial magnetic conductor plate, in the form of a bed of nails, is arranged surrounding the outer surface of the male flange, whereas a waveguide with broader hollow end serves as the female flange. The size of the proposed contactless flange is significantly reduced compared to its planer counterpart. An S-band prototype is designed, manufactured, and measured. Compared to traditional waveguide flange, the measured PIM level achieves a maximum improvement of 30 dB, which is almost unaffected by surface plating materials and connection pressure.
A New Frontier in Ultralow Power Wireless Links: Network-on-Chip and Chip-to-Chip Interconnects (2014)

This paper explores the general framework and prospects for on-chip and off-chip wireless interconnects implemented for high-performance computing (HPC) systems in the context of micro power wireless design. HPC interconnects demand very high (≥ 10 Gb/s) transmission rates using ultraefficient (~ 1 pJ/bit) transceivers over extremely short (≤ 100 cm) ranges. In an attempt to design such wireless interconnects, first a model for the wireless communication channel properties is developed. The use of CMOS-based energyefficient on-off keying (OOK) transceiver architectures operating in the 60-90 GHz bands is considered as a practical solution. In order to address strict performance requirements of wireless HPC interconnects, and taking advantage of the recent developments in device scaling, compact low-power and innovative circuits based on novel double-gate MOSFETs (DG-MOSFETs) are proposed in the implementation of the architecture. The performance of a compact low-noise amplifier (LNA) design using common source (CS) inductive degeneration with 32 nm DGMOSFETs is investigated by quantitative analysis and simulation. The proposed inductor-less two-stage cascode cascade LNA is optimized for 90 GHz operation and has the advantage of gain switching over its CMOS counterpart without the use of additional switching transistors, which makes it remarkably power efficient and faster. As further examples of efficient and compact DG-MOSFET circuits for OOK transceiver design, a three-stage CS 5 dB tunable power amplifier operating up to 90 GHz, and a novel 90 GHz voltage controlled oscillator are also presented. This is followed by the proposal of an array of four monopole antennas studied using full-wave EM solver.
The early maternal discharge clinical pathway: Health care's wave of the future (1995)

With increasing demands from external sources, maternal child providers are facing the chal lenges of accurate and timely assessments. Documentation for both legalities and reimburse ment can be accomplished through the clinical pathway. This article describes how one organi zation developed its pathways and how another developed its documents. Key words: early maternal discharge, maternal/newborn pathway, clinical pathway, postpartum clinical path way
Two Models of Corporate Governance: Beyond Berle and Means (2025)

This Article introduces a new model of corporate governance, which challenges, as did Berle and Means, the conclusions drawn from the traditional ownership model. Rather than focusing upon the inefficiencies of the large complex firm resulting from the separation of share ownership and control, however, this new model, which I call the power model, focuses upon the political nature of decision making in the large corporation, which exists regardless of the identity of the entrepreneur.
Spin-dependent magnetoresistance of ferromagnet/superconductor/ferromagnetLa0.7Ca0.3MnO3∕YBa2Cu3O7−δ∕La0.7Ca0.3MnO3trilayers (2007)

We report on large magnetoresistance in ferromagnet/superconductor/ferromagnet trilayer structures made of ${\mathrm{La}}_{0.7}{\mathrm{Ca}}_{0.3}{\mathrm{MnO}}_{3}$ and ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7}$. We find that the shape and height of the magnetoresistance peaks are not modified when the relative orientation of current and magnetic field is changed from parallel to perpendicular. Furthermore, we find that the temperature shift of the resistance curves is independent of current and of the sweep rate of the magnetic field. These observations favor the view that the magnetoresistance phenomenon originates in the spin dependent transport of quasiparticles transmitted from the ferromagnetic electrodes into the superconductor, and rule out interpretations in terms of spontaneous vortices or anisotropic magnetoresistance of the ferromagnetic layers.
p38 MAPK in pancreatic cancer: finding a protective needle in the haystack (2014)

Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma (PDAC) that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. The current findings support testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.
ULTIMATE-START: Subaru tomography adaptive optics research experiment project overview (2020)

ULTIMATE-Subaru Tomography Adaptive optics Research experimenT (ULTIMATE-START) is a laser tomography AO project on the Subaru telescope. The project is planned to achieve high Strehl Ratio AO correction in NIR bands, and moderate AO correction in visible bands above 600nm. An asterism of 4 laser guide stars (LGSs) will be launched from the laser launching telescope behind the secondary mirror. The tomography wavefront sensing unit with four 32$&#116;imes$32 Shack-Hartmann wavefront sensors will be installed behind the current facility LGS AO system, AO188. The deformable mirror of AO188 will be upgraded to a 64$&#116;imes$64 element DM. The corrected light will be fed to the optical integral field spectrograph, 3DII, and NIR camera and spectrograph, IRCS, through a beam switching optics for IR-side Nasmyth focus instruments under development. The first light of the laser launching system and wavefront sensing unit is planned in 2021.
Percutaneous Ultrasonographic Evaluation of the Spinal Cord After Cervical Laminoplasty (2014)

Assuming that good spinal cord pulsation represents good spinal circulation, these results suggest that the supine position will provide the most favorable condition for recovery of the cervical spinal cord.
EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture (2013)

Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell and antibody responses. The cues involved in positioning DCs in areas of antigen exposure in the spleen are undefined. Here we show that CD4(+) DCs highly express EBI2 and migrate to its oxysterol ligand, 7α,25-OHC. In mice lacking EBI2 or the enzymes needed for generating normal distributions of 7α,25-OHC, CD4(+) DCs are reduced in frequency and the remaining cells fail to situate in marginal zone bridging channels. The CD4(+) DC deficiency can be rescued by LTβR agonism. EBI2-mediated positioning in bridging channels promotes DC encounter with blood-borne particulate antigen. Upon exposure to antigen, CD4(+) DCs move rapidly to the T-B zone interface and promote induction of helper T cell and antibody responses. These findings establish an essential role for EBI2 in CD4(+) DC positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens. DOI:http://dx.doi.org/10.7554/eLife.00757.001.