gebhart/patrepeval huggingface dataset:
Analogues of a potent oxytocin antagonist with truncated c‐terminus or shorter amino acid side chain of the basic amino acid at position 8 (2003)

Twelve analogues were synthesized, their structure derived from modifications of [(S)Pmp1, D-Trp2, Pen6, Arg8]oxytocin, PA, in which (S)Pmp = beta,beta-(3-thiapentamethylene-beta-mercaptopropionic acid). PA is a potent antagonist of the uterotonic effect of oxytocin in the rat (uterotonic test in vitro, pA2 = 8.86) and in the baboon. Truncated analogues of PA from the C-terminus were systematically prepared ending in either the free acid or the amide, i.e. PA1-9 acid, PA1-8 acid, PA1-7 acid, PA1-6 acid, PA1-8 amide, PA1-7 amide and PA1-6 amide. PA1-8 amide was roughly as potent as PA in the rat uterotonic assay in vitro, and the shorter amides were only somewhat weaker antagonists. All four acid analogues were weaker antagonists than PA but still maintained rather high antagonistic potency. These findings suggest that, if these truncated acids form as metabolites in vivo, they may contribute to the overall biological effect of PA and their contribution should be taken into account. Furthermore, using these analogues, the radioimmunoassay measurements of PA may be standardized, as they may cross react with PA antibodies and interfere with the determination. In addition, five analogues were made by substituting Arg8 of PA with Lys, Orn8, Dab8, Dap8 and Cit8. All of these analogues maintained high potency as OTAs in the uterotonic assay, although their activity was only about 1.5-3 times lower than PA. The most potent analogue in the uterotonic assay, [Dap8]PA, pA2 = 8.53, had weak pressor activity (pA2 = 6.90) and no antidiuretic effect. The pressor activity was lower for all tested acids, and for PA1-6 acid it was even below the detection limit. Additionally, PA1-9 acid, PA1-7 acid and PA1-6 acid showed no antidiuretic activity. Hence, the PA1-6 acid is a potent OTA with pA2 = 8.27 and no measurable effect in the pressor or antidiuretic tests and thus it is a pure oxytocin antagonist. This fact makes it an attractive candidate for further studies on inhibition of OT biological effects and on preterm labour.
Heterogeneous integration Roadmap (2017)

This paper describes the background, purpose, mission, scope and schedule of the Heterogeneous Integration Roadmap. With the electronics industry entering an era of acceleration and disruption, the role of Heterogeneous Integration will prove very important in response to the driving forces of IoT, Data Centers, Smart Mobile and Intelligent Automotive. It addresses the future vision for hardware challenges and for innovation with strong focus for Heterogeneous Integration. The goal for the Heterogeneous Integration Roadmap is to be of service to the Profession, Industry, Academia, and Research Institutes.
Development of Bearing Steels for Special Environment (2004)

Recent improvements in the quality of steels have meant that rolling bearings are largely free from materials defects. Therefore, damage generated during the operating life of the component becomes the main source of failure. This damage is frequently caused by overheating at a higher speed operation or by the overrolling of debris paricles in the lubricant. A new bearing steel, named STJ2, for high temperature service was developed in the view of supressing rolling contact fatigue phenomenon, which is accelerated by the heat occur at raceway. STJ2 showed a longer life than cnventional JIS-SUJ2 steel in a bearing test at 473K, and have been applied to spherical roller bearings produced by NTN Corp. Another bearing grade for contaminated lubricant service was designed with the control of retained austenite in a steel. Adequate amount of retained austenite that prolonged the rolling contact fatigue life under a contaminated lubricant was obtained by the addition of manganese more than 2 mass%. This new steel has just been begun to introduce to domestic and foreign bearing manufacturers.
Barker-coded ultrasound color flow imaging: theoretical and practical design considerations (2007)

Barker-coded excitation is applied to improve the sensitivity versus resolution tradeoff for ultrasound color flow imaging (CFI). Direct sequence encoding and complex baseband decoding methods that enable flexible combination of demodulation frequency and Barker-chip duration are proposed. Based on a general Wiener decoding filter formulation, three different conditions that pertain to the relationship between the Barker-chip duration and demodulation frequency are found, such that they result in real, complex symmetric and complex asymmetric decoding filter sequences, respectively. It is also shown that the matched filter and the inverse filter represent two extreme cases of the Wiener filter, and the latter is proposed for decoding Barker-coded CFI signals with maximum range sidelobe suppression. Some practical considerations such as coding gain, integrated sidelobe level (ISL) and peak sidelobe level (PSL) for various decoding filter lengths, and the influence of flow rate also are analyzed. Linear array imaging of steady flow in straight tubes is simulated based on a 4-cycle base pulse at 6.25 MHz, a 5-chip Barker code, a 32-tap decoding filter, and standard color flow data processing. The resultant color flow images demonstrate the expected improvements in penetration and axial resolution.
[Value of the monitoring of the facial nerve in the evaluation of facial function in translabyrinthine surgery for acoustic neuroma]. (1994)

Amongst the 62 patients operated for acoustic neuroma using a translabyrinthine approach, the authors study post operatory results at one month of the facial function according to the "House-Brackmann" classification. The analysis consists in 2 homogeneous and comparable series of 34 and 28 patients having benefited or not of a per operatory monitoring of the facial nerve with "NIM 2" neuro monitor. Without distinction of the tumoral sizes 76% of patients show a good facial result when monitorized against 60.7% when not. According to the tumoral size monitoring becomes more interesting: also you will find better results in the monitorized serial (71%) against 29% without. Other factors concerning the facial post operatory functions are also analysed by authors. To the very important part of per operatory monitoring, the anatomical status, microvascularization and physiological state of the nerve al as well as the operator's experience are to be added. All above factors must be considered when evaluating the final post operatory facial result.
Time course of EEG complexity reflects attentional engagement during listening to speech in noise (2023)

Distraction caused by auditory noise poses a considerable challenge to the quality of information encoding in speech comprehension. The aim of this study was to explore the temporal dynamics and complexity of electroencephalog-raphy (EEG) microstates in relation to attentional engage-ment over time, contributing to the understanding of speech perception in noise. We examined three listening condi-tions: speech perception with background noise, focused attention on the background noise, and intentional disre-gard of the background noise. Our findings revealed an increase in complexity during the transition of microstates and a slower microstate recurrence when individuals directed their attention to speech compared to tasks without speech. Additionally, a two-stage time course for both microstate complexity and alpha-to-theta power ratio was observed. Specifically, in the early epochs, a lower level was observed, which gradually increased and eventually reached a steady level in the later epochs. The findings suggest that the ini-tial stage is primarily driven by sensory processes and infor-mation gathering, while the second stage involves higher-level cognitive engagement, including mnemonic binding and memory encoding.
Erratum to: Risk Factors Affecting Outcome of Metal-on-Metal Surface Arthroplasty of the Hip (2011)

Erratum to: Clin Orthop Relat Res (2004) 418:87−93 In the original version of this article, which appeared in Volume 418, pages 87-93, the author listed as “Michel LeDuff, MA” should be listed as “Michel J. Le Duff, MA”.
High sensitivity MEMS capacitive hydrogen sensor with inverted T-shaped electrode and ring-shaped palladium alloy for fast response and low power consumption (2018)

We report a novel palladium (Pd)-based micro electro-mechanical system (MEMS) capacitive hydrogen gas sensor that has an inverted T-shaped electrode and a ring-shaped Pd alloy layer, which enable high sensitivity and low power consumption. Thanks to these structures, deformation of the membrane as a result of hydrogen absorption can be efficiently transduced to capacitance change. The capacitance change of the proposed sensor is found to be three times larger than that of the conventional structure. Prototype sensors were fabricated by a CMOS-compatible surface micromachining process. The proposed sensor offers a broad design window for attaining high sensitivity. Finally, we show that our sensor provides fast response, is hysteresis-free, and has excellent hydrogen selectivity characteristics despite not employing a heater by using PdCuSi metallic glass.
Magnetic Susceptibilities of Solutions of Potassium in Molten Potassium Chloride (1966)

Volume magnetic susceptibilities have been measured by the Gouy method for molten potassium chloride and for 7 and 15 mole % solutions of potassium metal in molten potassium chloride, between 800° and 1000°C. All these liquids are diamagnetic, but the potassium solute appreciably reduces the diamagnetism of the solvent. Making some assumptions about the densities (unmeasured) of the solutions and about the additivity of the ionic diamagnetism, it is possible to compute molar paramagnetic susceptibilities for the potassium valence electrons. These values can be very roughly accounted for by the equation for conduction-band electrons, with the effective electron mass approximately equal to the free electron mass. Alternatively, one can account for the data by localized electron models. One such model, based on a number of assumptions, is presented in the discussions. It leads to the conclusion that there exists a slight energy of association, of the order of kT or less, of potassium solute atoms into nearest-neighbor clusters.
EVALUATION OF BUTACHLOR FOR CONTROL OF SUBMERGED MACROPHYTES ALONG WITH ITS IMPACT ON BIOTIC COMPONENTS OF FRESHWATER SYSTEM (2006)

In this investigation, the efficacy of the herbicide butachlor, (N-butoxymethyl-2 chloro-21, 61 diethyl acetanilide) was tested against few common submerged macrophytes namely Hydrilla (Hydrilla verticillata (L.) Royale), Najas (Najas minor All.), Nechamandra (Nechamandra alternifolia (Roxb.) Thwaites) and Ottelia (Ottelia alismoides (L.) Pers.) of freshwater fish ponds. Almost complete decay of Hydrilla, Nechamandra and Ottelia was achieved at 7.5 L of active ingredient/ha/m butachlor within 15 days while the herbicide showed no negative effect on Najas. However at the same concentration of butachlor, total mortality of zooplankton and water fern Azolla (Azolla caroliniana Lamarck) occurred
within seven days. In case of few freshwater fish species like Rohu (Labeo rohita), Channa (Channa punctatus), Anabas (Anabas testitudineus) and Heteropneustes (Heteropneustes fossilis), total mortality occurred upto 90 days after application of the same dose of butachlor but fish survived beyond 120 days of herbicide application indicating degradation of the herbicides.
Scenario-Dependent ZUPT-Aided Pedestrian Inertial Navigation with Sensor Fusion (2021)

Pedestrian navigation has been of high interest in many fields, such as human health monitoring, personal indoor navigation, and localization systems for first responders. Due to the potentially complicated navigation environment, selfcontained types of navigation such as inertial navigation, which do not depend on external signals, are more desirable. Pure inertial navigation, however, suffers from sensor noise and drifts and therefore is not suitable for long-term pedestrian navigation by itself. Zero-velocity update (ZUPT) aiding technique has been developed to limit the navigation error growth, but adaptivity of algorithms, model fidelity, and system robustness have been major a concern if not properly addressed. In this paper, we attempt to establish a common approach to solve the problem of self-contained pedestrian navigation by identifying the critical parts of the algorithm that have a strong influence on the overall performance. We first review approaches to improve the navigation accuracy in each of the critical part of implementation proposed by other groups. Then, we report our results on analytical estimations and experiments illustrating effects of combining inertial sensor calibration, stance phase detection, adaptive model selection, and sensor fusion.
Unresolved-issues concerning the final disposal of nuclear material discards (1994)

The 1989 International Atomic Energy Agency Consultants` Meetings for Development of Technical Criteria for Termination of Safeguards for Material Categorized as Measured discards did not produce a consensus of opinion on several significant issues. This paper presents summary information form studies performed on two of the issues: recoverability of nuclear material from high activity waste and inert dilution of wastes. Concerns regarding recoverability of nuclear material in the wastes first require resolution of political and technical issues before technical criteria can be finalized. Potential termination criteria based on ratios of fission products to nuclear material content are identified that could be used to resolve the inert dilution concerns associated with high-activity liquid waste.
Open project (2013)

The form factor of mobile devices remains small while their computing power grows at an accelerated rate. Prior work has explored expanding the output space by leveraging free displays in the environment. However, existing solutions often do not scale. In this paper we discuss Open Project, an end-to-end framework that allows a user to "project" a native mobile application onto a display using a phone camera, leveraging interaction spaces ranging from a PC monitor to a public wall-sized display. Any display becomes projectable instantaneously by simply accessing the lightweight Open Project server via a web browser. By distributing computation load onto each projecting mobile device, our framework easily scales for hosting many projection sessions and devices simultaneously. Our performance experiments and user studies indicated that Open Project supported a variety of useful collaborative, sharing scenarios and performed reliably in diverse settings.
Influence of Oxygen on Reactivity of Ru[sub 1−x]Fe[sub x]O[sub 2−y]-Doped Materials (2008)

Single-phase iron-substituted nanocrystalline ruthenium dioxide with composition and of rutile structure was prepared. The electrocatalytic behavior of the prepared materials was tested with respect to oxygen evolution reaction and chlorine evolution reaction (CER) The substitution with iron leads to a slight increase of the material's activity toward oxygen evolution. The selectivity of iron-doped materials in parallel oxygen and chlorine evolution is affected by oxygen content in the electrolyte solution. The CER is preferred in oxygen-free solutions; in oxygen-saturated solutions oxygen evolution is enhanced.
Performance of pre-production band 1 receiver for the Atacama Large Millimeter/submillimeter Array (ALMA) (2018)

The Atacama Large Millimeter/submillimeter Array (ALMA) Band 1 receiver covers the frequency range of 35-50 GHz. An extension of up to 52 GHz is on a best-effort basis. A total of 73 units have to be built in two phases: 8 preproduction and then 65 production units. This paper reports on the assembly, testing, and performance of the preproduction Band 1 receiver. The infrastructure, integration, and evaluation of the fully-assembled Band 1 receiver system will be covered. Finally, a discussion of the technical and managerial challenges encountered for this large number of receivers will be presented.
ChemInform Abstract: ON THE ROLE OF IRON DISSOLUTION IN CRACK PROPAGATION DURING HYDROGEN CHARGING OF AN FE‐PT ALLOY (1973)

Abstract Die Auflösung von Fe und seinen Legierungen bei der kathodischen Wasserstoffbeladung ist im allgemeinen im Einklang mit den thermodynamischen Oberflächenbedingungen vernachlässigbar gering.
Figure S3 from Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells (2023)

&lt;p&gt;Thsi figure further describes the molecular effects of ATF4 inhibition and ISRIB during asparagine starvation.&lt;/p&gt;
A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from beta-Thalassemia Major: A Pilot Study (2020)

Abnormal immune reactivity in patients with beta-thalassemia (beta-thal) major can be associated with poor prognosis. Immunome protein-array analysis represents a powerful approach to identify novel biomarkers. The Sengenics Immunome Protein Array platform was used for high-throughput quantification of autoantibodies in 12 serum samples collected from nine beta-thal major patients and three non-thalassemia controls, which were run together with two pooled normal sera (Sengenics Internal QC samples). To obtain more accurate and reliable results, the evaluation of the biological relevance of the shortlisted biomarkers was analyzed using an Open Target Platform online database. Elevated autoantibodies directed against 23 autoantigens on the immunome array were identified and analyzed using a penetrance fold change-based bioinformatics method. Understanding the autoantibody proﬁle of beta-thal major patients would help to further understand the pathogenesis of the disease. The identified autoantigens may serve as potential biomarkers for the prognosis of beta-thal major.
Graph-Based User Behavior Modeling (2015)

How can we model users' preferences? How do anomalies, fraud, and spam effect our models of normal users? How can we modify our models to catch fraudsters? In this tutorial we will answer these questions - connecting graph analysis tools for user behavior modeling to anomaly and fraud detection. In particular, we will focus on the application of subgraph analysis, label propagation, and latent factor models to static, evolving, and attributed graphs. For each of these techniques we will give a brief explanation of the algorithms and the intuition behind them. We will then give examples of recent research using the techniques to model, understand and predict normal behavior. With this intuition for how these methods are applied to graphs and user behavior, we will focus on state-of-the-art research showing how the outcomes of these methods are effected by fraud, and how they have been used to catch fraudsters.
The advantage of chimeric antigen receptor T cell therapy in pediatric acute lymphoblastic leukemia with E2A-HLF fusion gene positivity: a case series (2021)

The E2A-HLF fusion gene is a very poor biomarker in acute lymphoblastic leukemia (ALL) because of its high relapse risk, even with the most intensive chemotherapy and hematopoietic stem cell transplantation (HSCT). Here, we analyzed four cases diagnosed with E2A-HLF fusion gene-positive B-ALL and treated with the CCCG-ALL-2015 protocol based on high-risk stratification from Jun 2017 to May 2020 retrospectively. Three cases (Case 1, 2, 3) were insensitive to conventional therapy and inhibitors with high-level MRD on days 19 and 46, but they all achieved complete remission at the molecular level with Chimeric Antigen Receptor (CAR) T cell therapy regardless of primary resistance or recurrence. Although remission was initially achieved for Case 4, chemotherapeutics was not sensitive after recurrence. However, CAR-T cell therapy gave him the chance to obtain complement remission again. Cytokine release syndrome (CRS) with fever, chills, acute kidney injury, hypotension and capillary leak syndrome and CAR-T related encephalopathy syndrome (CRE) with seizures and encephaledema occurred after CAR-T cell therapy, but symptoms disappeared with effective intensive care. Overall, CAR-T cell therapy enabled the patients to achieve complement remission with controllable adverse events. Our results indicated that CAR-T cell therapy is a feasible and effective therapy for patients with E2A-HLF-positive B-ALL and prompted the authors to report these cases.
Un fragment de Néchepso (P.IFAO inv. 313) (2000)

International audience
Decreased clearance ofPseudomonas aeruginosafrom airways of mice deficient in lysozyme M (2005)

Lysozyme is a ubiquitous and abundant, cationic, antimicrobial polypeptide of leukocytes and epithelia, but its biological function in host defense is largely unexplored. To ascertain the role of lysozyme during bacterial infection of murine airways, we exposed the airways of lysozyme M-deficient (lys M-/-) mice to the pulmonary pathogen Pseudomonas aeruginosa and examined the host's response to infection. Despite partial compensation as a result of the appearance of lysozyme P in the infected airways of lys M-/- mice, these lys M-/- mice showed decreased clearance of P. aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways.
Local magnetic and geometric structure in Mn-doped La(Fe,Si)13 (2023)

Magnetic cooling has the potential to replace conventional gas compression refrigeration. Materials such as La(Fe,Si)$_{13}$ exhibit a sizeable first-order magnetocaloric effect, and it is possible to tailor the phase transition towards room temperature by Mn-H-doping, resulting in a large temperature range for operation. Within this work, we discuss variations of the electronic and lattice structure in La(Fe,Si)$_{13}$ with increasing Mn content utilizing X-ray magnetic circular dichroism (XMCD) and extended X-ray absorption fine structure spectroscopy (EXAFS). While XMCD shows a decrease of the magnetic polarization at the Fe K edge, low-temperature EXAFS measurements indicate increased positional disorder in the La environment that is otherwise absent for Fe and Mn. First-principles calculations link the positional disorder to an enlarged Mn-Si distance -- explaining the increased positional disorder in the La surrounding.
Characterization of Glutamate Decarboxylase from Lactobacillus plantarum and Its C-Terminal Function for the pH Dependence of Activity (2014)

The gadB gene encoding glutamate decarboxylase (GAD) from Lactobacillus plantarum was cloned and expressed in Escherichia coli. The recombinant enzyme exhibited maximal activity at 40 °C and pH 5.0. The 3D model structure of L. plantarum GAD proposed that its C-terminal region (Ile454-Thr468) may play an important role in the pH dependence of catalysis. Accordingly, C-terminally truncated (Δ3 and Δ11 residues) mutants were generated and their enzyme activities compared with that of the wild-type enzyme at different pH values. Unlike the wild-type GAD, the mutants showed pronounced catalytic activity in a broad pH range of 4.0-8.0, suggesting that the C-terminal region is involved in the pH dependence of GAD activity. Therefore, this study may provide effective target regions for engineering pH dependence of GAD activity, thereby meeting industrial demands for the production of γ-aminobutyrate in a broad range of pH values.