gebhart/patrepeval huggingface dataset:
Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli (1995)

Developing lymphocytes undergo extensive cell death during selection of the immune repertoire. We investigated the influence of bcl-xL, a member of the bcl-2 family of apoptosis regulatory genes, on apoptosis in a model system for negative selection in the B lymphoid lineage. Overexpression of bcl-xL in WEHI 231 immature mouse B cells blocked apoptosis triggered by cross-linking of surface IgM. bcl-xL-transfected cells were also resistant to apoptosis following incubation in low serum medium or exposure to gamma-irradiation, the sphingomyelin ceramide, or compounds that increase intracellular levels of oxidants. Remarkably, the addition of antioxidants (catalase, N-acetylcysteine, or pyruvate) alone rescued the native WEHI 231 cells from apoptosis while having only minor effects on the viability of cells overexpressing bcl-xL. Anti-IgM cross-linking, ceramide, and gamma-irradiation treatments elevated intracellular peroxide production, which was prevented by treatment with antioxidants. Cells overexpressing bcl-xL had a similar rise in intracellular oxidants as control cells, indicating that bcl-xL modifies the cell's response to oxidants while having no detectable influence on the endogenous production of oxidants following apoptotic stimuli. These data implicate bcl-xL as a potent death repressor in B lymphocytes and support the hypothesis that bcl-xL regulates survival decisions within susceptible cells by functioning downstream of oxidant production.
Regulation of Senescence in Carnation (Dianthus caryophyllus) (1976)

Abscisic acid hastened senescence of carnation flowers and this was preceded by stimulation of accelerated ethylene production. Carbon dioxide delayed the onset of autocatalytic ethylene production in flowers regardless of treatment with abscisic acid. Flowers exhibited a low and transient climacteric of ethylene production without wilting while in 4% carbon dioxide and underwent accelerated ethylene production culminating in wilting when removed from carbon dioxide. Hypobaric ventilation, which lowers ethylene to hyponormal levels within tissues, extended flower longevity and largely negated enhancement of senescence by abscisic acid. Supplementing hypobarically ventilated flowers with ethylene hastened senescence irrespective of abscisic acid treatment. Collectively, the data indicate that abscisic acid hastens senescence of carnations largely as a result of advancing the onset of autocatalytic ethylene production.
A Data-Driven Variable-Gain Control Strategy for an Ultra-Precision Wafer Stage With Accelerated Iterative Parameter Tuning (2015)

Wafer stage is an important mechatronic unit of industrial lithography tool for manufacturing integrated circuits. To overcome the inherent limitations of fix-gain feedback control and improve the servo performance, a performance-oriented variable-gain control strategy with accelerated iterative parameter tuning is proposed for an ultra-precision wafer stage. The variable-gain controller comprises a fix-gain proportional-integral-derivative (PID) controller and add-on variable-gain elements, which are the focus of this paper. Specifically, the add-on variable-gain elements are significantly designed based on the main tracking error sources and error frequency of different reference trajectory phases. A weighted two-norm regarding the performance indexes of wafer stages, i.e., moving average (MA) and moving standard deviation (MSD) of the tracking error, is synthesized as the objective function, and the data-driven Levenberg–Marquardt-based iterative parameter tuning scheme is employed to find the optimal parameter values of the proposed variable-gain controller. Furthermore, to improve the convergence rate, a multiparameter accelerated iterative method is developed based on Aitken’s method. Finally, the proposed variable-gain control strategy is implemented on an ultra-precision wafer stage developed in our laboratory. Comparative experimental results demonstrate that the strategy performs best and achieves excellent improvement on both MA and MSD. During the scanning phase, MA and MSD are less than 1.02 and 2.35 nm, respectively. The proposed variable-gain control strategy is also suitable for other industrial applications.
Chromosomal evolution and phylogeny in the Nullicauda group (Chiroptera, Phyllostomidae): evidence from multidirectional chromosome painting (2018)

The occurrence of the karyotype considered ancestral for this family in several different branches suggests that the diversification of Phyllostomidae into many subfamilies has occurred in a short period of time. Finally, the comparison with published maps using human whole chromosome probes allows us to track some syntenic associations prior to the emergence of this family.
SecureAngle (2010)

Wireless networks play an important role in our everyday lives, at the workplace and at home. However, they are also relatively vulnerable: physically located off site, attackers can circumvent wireless security protocols such as WEP, WPA, and even to some extent WPA2, presenting a security risk to the entire network. To address this problem, we propose SecureAngle, a system designed to operate alongside existing wireless security protocols, adding defense in depth. SecureAngle leverages multi-antenna APs to profile the directions at which a client's signal arrives, using this angle-of-arrival (AoA) information to construct signatures that uniquely identify each client. We identify SecureAngle's role of providing a fine-grained location service in a multi-path indoor environment. With this location information, we investigate how an AP might create a "virtual fence" that drops frames received from clients physically located outside a building or office. With SecureAngle signatures, we also identify how an AP can prevent malicious parties from spoofing the link-layer address of legitimate clients. We discuss how SecureAngle might aid whitespace radios in yielding to incumbent transmitters, as well as its role in directional downlink transmissions with uplink AoA information.
The Temperament and Character Inventory in women with migraine (2005)

The purpose of this work was to investigate: (1) the differences in temperament and character between 49 women with migraine and 49 controls using the Temperament and Character Inventory (TCI), and (2) the extent to which these differences were related to migraine or to the presence of comorbid depression. The migraine patients scored significantly higher than the controls in two temperament dimensions-Harm Avoidance (HA) and Persistence (P)-and significantly lower in one character dimension-Self-Directedness (SDir) (Student's t). After multiple logistic regression, the TCI P and HA dimensions were significantly associated with the presence of migraine. The HA dimension was also related to the presence of depression. Our results show that in migraine the higher HA score could be partly associated to comorbid depression while the high P dimension seems to be solely related to the presence of migraine.
Spectroscopic Properties of Inorganic and Organometallic Compounds (1999)

Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr
Supplementary Figure 3 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus (2023)

&lt;p&gt;TSC2 immunohistochemistry assay validation and analysis of HCC xenograft and primary tumors. (A) TSC2 immunohistochemistry (IHC) assay with HCC cell lines. (B) TSC2 IHC assay with HCC xenograft tumors. (C) TSC2 expression by IHC assay in HCC xenografts and their corresponding primary tumors.&lt;/p&gt;
Preparation of Fused Polycyclic Vinylcyclopropanes via Radical Cascade Reactions. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bridge Embankments. I: Seismic Risk Assessment and Ranking (2008)

The objective of this study is to provide a simple methodology to conduct preliminary seismic assessment and ranking of bridge embankments in order to identify and prioritize embankments that are susceptible to failure. A ranking model that provides a priority list of embankments with the highest seismic risk of failure is generated. A step-by-step methodology is presented in a flowchart to estimate the seismic slope stability capacity/demand ratio, displacement, and liquefaction potential of bridge embankments. Three categories are presented to identify the failure risk of the embankments. The ranking model is useful for a quick sensitivity assessment of the effect of various site conditions, earthquake magnitudes, and site geometry on possible movement of designated embankments. The priority list will enable decision makers to decide on either carrying out further detailed evaluation or consider other appropriate actions for the bridge embankments with the highest seismic failure risk.
A Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa (1998)

There may be a common familial vulnerability for anorexia nervosa and bulimia nervosa. Major depressive disorder, obsessive-compulsive disorder, and substance dependence are not likely to share a common cause with eating disorders. However, obsessional personality traits may be a specific familial risk factor for anorexia nervosa.
Hydrolyse Enzymatique de la Cellulose (1980)

peer reviewed
ChemInform Abstract: Asymmetric Catalysis of Intramolecular N‐H Insertion Reactions of . alpha.‐Diazocarbonyls. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Insulin secretion by pancreatic tissue in vitro (1966)

Comm. Fed. Amer. Soc. Exp. Biol. - Atlantic City, 14.4.1966
10808 Operation with a Real Biogas by Using a Natural-Gas Engine Power-Generation System (2014)

This paper presents operation with a real biogas produced through a low-temperature biomass gasification process by using a natural gas engine power generation system. The biomass resource was wood chips, which produces real biogas containing hydrogen, methane and carbon monoxide as fuels together with carbon dioxide and nitrogen as diluents. Real biogas gives sufficiently stable operation with the COV of IMEP_g of less than 5 %. The maximum gross indicated thermal efficiency was more than 45 %, which was even higher than that of natural gas even at the BMEP of less than 0.4 MPa. From the above, it can be said that biogas is more suitable fuel for lean burn.
Intramolecular Radiative and Radiationless Charge Recombination Processes in Donor−Acceptor Carbazole Derivatives (1997)

Photoinduced intramolecular charge transfer (ICT) in a series of N-bonded donor−acceptor derivatives of 3,6-di-tert-butylcarbazole containing benzonitrile, nicotinonitrile, or various dicyanobenzenes as an electron acceptor has been studied in solutions. The latter group of compounds, contrary to benzonitrile and nicotinonitrile derivatives, shows a well-separated low-energy CT absorption band which undergoes a distinct blue shift with increasing solvent polarity. Solvatochromic effects on the spectral position and profile of the stationary fluorescence spectra clearly indicate the CT character of the emitting singlet states of all of the compounds studied both in a polar and a nonpolar environment. An analysis of the CT fluorescence and absorption band shapes leads to the quantities relevant for the electron transfer in the Marcus inverted region. The values of the fluorescence rate constants (kf) and corresponding transition dipole moments (M) and their solvent polarity dependence indicate that the electronic coupling between the emitting 1CT state and the ground state is a governing factor of the radiative transitions. The relatively large values of M indicate a nonorthogonal geometry of the donor and acceptor subunits in the fluorescent states. It is shown that Marcus theory can be applied for the quantitative description of the radiationless charge recombination processes in the cases when an intersystem crossing to the excited triplet states can be neglected.
An Investigation of the Redox Stability of an Anode-Supported SOFC Stack Using Acoustic Emission Monitoring (2021)

The mechanical stability of an SOFC stack is compromised when its cells operate in oxidation-reduction (Redox) environments. Previous studies, based mainly on voltage-current or electrochemical impedance measurements, showed that cell performance degraded upon redox cycling above 600°C. Therefore, the purpose of this work is to investigate the Redox process and the stability of a SOFC stack applying the Acoustic Emission (AE) monitoring technique. The investigation includes the interpretation of AE events and signals considering their waveform and frequency content.
Glucose Content and Efficiency of Glycolysis in Protected Ischemic Kidneys of Different Species (1990)

In ischemic canine kidneys protected by Bretschneider's HTK solution the glycolytic lactate production is limited by a low renal substrate content. However, for anaerobic energy supply ischemic organs depend on glycolysis. To evaluate the role of glycolysis in renal protection, the relationship between lactate production and anaerobic energy supply was examined in protected kidneys of dogs, sheep, and swine. Additionally, in canine kidneys an attempt was made to improve anaerobic energy provision by adding glucose to the protective solution. The results were as follows: (1) According to increasing lactate production from swine to dog to sheep, intraischemic ATP decay was delayed least in swine and most in sheep. (2) Glucose addition (10 mM) to the HTK solution roughly doubled the time for ATP to fall to 1 mumol/g dry wt (tATP) in dogs. (3) The greater the lactate production in all three species, the lower the decrease in SAN (ATP + ADP + AMP) from 5 to 120 min of ischemia. (4) A glucose additive in the protective solution led to a significant (p less than .005) increase of SAN in dogs at 120 min of ischemia. A sufficient substrate supply seems to be an essential component of a reliable renal protection.
Comparison of the vascular effects of adenosine in isolated mouse heart and aorta (2002)

The present study was designed to characterize and compare the vascular effects of adenosine and its analogs in the murine heart and aorta. Mouse hearts perfused under constant pressure in standard Langendorff fashion demonstrated concentration-dependent increases in coronary flow to adenosine, 2-chloradenosine (CAD), 5'-(N-ethyl-carboxamido)-adenosine (NECA), and 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxam-idoadenosine (CGS-21680). All agonists produced comparable increases in coronary flow with the following order of potency: CGS-21680 = NECA >> CAD > or = adenosine. In l-phenylephrine hydrochloride (phenylephrine) precontracted aortic rings, all nonselective agonists (NECA, CAD, and adenosine) produced marked concentration-dependent relaxation, whereas the adenosine A(2A) selective agonist CGS-21680 did not. Adenosine receptor agonists were >100 times more potent for coronary vasodilation than aortic vasorelaxation. The selective A(2A) receptor antagonist 5-amino-7-(beta-phenylethyl)-2-(8-furyl)pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine (SCH-58261) blocked both CGS-21680- and NECA-induced increases in coronary flow, whereas the A(2B) receptor antagonist benzo[g]pteridine-2,4(1H,3H)-dione (alloxazine) inhibited NECA-induced aortic relaxation. These data indicate a differential response to adenosine agonists in murine coronary vasculature and aorta where coronary vasodilation is mediated predominantly by activation of A(2A) adenosine receptors.
Simulating NIRS and MRS Measurements During Cerebral Hypoxia-Ischaemia in Piglets Using a Computational Model (2014)

We present a group analysis of the changes in cerebral haemodynamics, and the oxidation state of cytochrome-c-oxidase measured using broadband near-infrared spectroscopy (NIRS) and intracellular pH measured by phosphorous ((31)P) magnetic resonance spectroscopy (MRS) during and after cerebral hypoxia-ischaemia (HI) in 15 piglets. We use a previously published computational model of cerebral metabolism in the piglet [1] to integrate these measurements and simulate HI. We successfully simulate changes in cellular metabolism including shifts in intracellular pH observed in the piglet brain during HI. In this process, we optimise physiological parameters in the model identified through sensitivity analysis (such as the rate of glucose metabolism and intracellular lactate concentration), to fit simulated and measured data. The model fits the data reasonably and suggests a 20 % drop in glucose consumption, a ~65 % increase in lactate concentration and ~35 % drop in the cerebral metabolic rate of oxygen (CMRO₂) during HI.
Change in Color Perception with Aging (1998)

It has been reported that color perception of bluish lights changes with age because of a considerable decrease of the sensitivity in short-wavelength region caused by the yellowing of the crystalline lens. However there is an opinion that the color perception of aged-people is compensated by chromatic adaptation since the yellowing of the crystalline lens gradually grows across the life-span.
Soot Formation from a Bio-derived High Performance Jet Fuel (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-1447.vid Sustainable aviation fuels can reduce carbon emissions from jet engines. Farnesane is a biofuel that has properties similar to jet fuel. In this work, shock tube studies are conducted for a farnesane mixture and ethylene mixture under sooting conditions. The soot measurement is done using the laser-induced extinction method to measure soot induction time and soot volume fraction time-histories at 1850 K and ~4 atm. The results presented herein will be a useful validation target for developing kinetic models for soot formation.
Fusion of the Escherichia coli lac genes to the ara promoter: a general technique using bacteriophage Mu-1 insertions. (1975)

The lac genes were fused to the ara promoter by means of phage phi 80 translocations of the lac and ara genes to att80. Homology for a crossover between the nonhomologous ara and lac operons was provided by mu insertions. Selection for recombinants within the mu insertions generated strains that had the ara promoter on one side of a mu insertion and the lac genes on the other side. ara-lac fusions were obtained from these strains by deleting the mu insertion. These fusions extend the techniques available for studies on the lac operon to studies on the ara operon. It should be possible to fuse other operons by this method.
Background Aerosols and BW Detection: Problems and Suggested Solutions (2002)

Abstract : Detection of Biological Warfare (BW) Agents is a formidable task, exacerbated by the fact that some microbes can be highly infective. Thus, only a few microbes delivered to an appropriate site can cause disease. Because of this issue, detectors need to have very high sensitivity. To further complicate things, the atmosphere frequently contains abundant biological and nonbiological particles that can interfere with the detection process, thus creating false alarms. In this report, the authors briefly review the difficulties that background aerosols cause in the detection process and suggest possible ways of alleviating these difficulties.
Damage-Associated Molecular Patterns Control Neutrophil Recruitment (2013)

Neutrophils are recruited to a site of infection or injury where they help initiate the acute inflammatory response. In instances of sterile inflammation, where no microbial threats are present, this neutrophil recruitment is mediated by the release of danger signals or damage-associated molecular patterns (DAMPs) from disrupted cells and tissues. At basal state, many of these substances are sequestered and remain hidden within the cell, but are released following the rupture of the plasma membrane. In other instances, these DAMPs are undetected by the innate immune system unless chemically or proteolytically modified by tissue damage. DAMPs may be directly detected by neutrophils themselves and modulate their recruitment to sites of damage or, alternatively, they can act on other cell types which in turn facilitate the arrival of neutrophils to a site of injury. In this review, we outline the direct and indirect effects of a number of DAMPs, notably extracellular ATP, mitochondrial formylated peptides and mitochondrial DNA, all of which are released by necrotic cells. We examine the effect of these substances on the recruitment and behaviour of neutrophils to sites of sterile injury. We also highlight research which suggests that neutrophils are actively involved in triggering the resolution phase of an inflammatory response. This review brings to light a growing body of work that demonstrates that the release of DAMPs and the ensuing influx of neutrophils plays an important functional role in the inflammatory response, even when no pathogens are present.